1 00:00:05,000 --> 00:00:08,800 >>WELCOME TO THE 2 00:00:08,800 --> 00:00:10,760 204TH MEETING OF THE NATIONAL 3 00:00:10,760 --> 00:00:11,320 INSTITUTE OF ALLERGY AND 4 00:00:11,320 --> 00:00:15,480 INFECTIOUS DISEASES. THIS IS 5 00:00:15,480 --> 00:00:16,120 THE OPEN SESSION AND SO WE ARE 6 00:00:16,120 --> 00:00:20,400 JOINED BY MEMBERS OF LAY AND 7 00:00:20,400 --> 00:00:21,040 PROFESSIONAL ORGANIZATIONS THAT 8 00:00:21,040 --> 00:00:21,720 SHARE INTEREST WITH OURS AND WE 9 00:00:21,720 --> 00:00:26,880 WELCOME THEM HERE. LET ME 10 00:00:26,880 --> 00:00:30,680 INTRODUCE THREE -- KEYBOARD NOT 11 00:00:30,680 --> 00:00:40,560 WORKING, WHAT HAPPENED? 12 00:00:40,560 --> 00:00:50,560 >> 13 00:00:52,440 --> 00:00:53,040 >>... THREE AD HOC MEMBERS OF 14 00:00:53,040 --> 00:00:53,960 COUNCIL FOR THE SESSION AND ON 15 00:00:53,960 --> 00:00:58,680 ZOOM WE HAVE -- FROM FRANCE AND 16 00:00:58,680 --> 00:00:59,240 IN THE ROOM WE HAVE KEVIN 17 00:00:59,240 --> 00:01:04,960 HAROLD AND MARK ANDERSON-- IT 18 00:01:04,960 --> 00:01:05,560 IS PARTICULARLY A PLEASURE TO 19 00:01:05,560 --> 00:01:06,680 WELCOME THE THREE OF YOU AS OLD 20 00:01:06,680 --> 00:01:10,480 FRIENDS TO OUR COUNCIL. AND I 21 00:01:10,480 --> 00:01:11,040 HAVE WATCHED OVER YOUR WORK 22 00:01:11,040 --> 00:01:11,680 OVER DECADES NOW FOR TREATMENT 23 00:01:11,680 --> 00:01:12,240 TO ADD RISK PATIENTS WITH 24 00:01:12,240 --> 00:01:15,160 DIABETES. I AM LOOKING FORWARD 25 00:01:15,160 --> 00:01:15,760 THIS AFTERNOON TO HEARING THE 26 00:01:15,760 --> 00:01:17,840 STORY OF WHAT YOU HAVE DONE AT 27 00:01:17,840 --> 00:01:22,080 THE DAYS SUBCOMMITTEE. 28 00:01:22,080 --> 00:01:22,680 FIRST ORDER OF BUSINESS IS TO 29 00:01:22,680 --> 00:01:27,000 APPROVE THE MINUTES. THE 30 00:01:27,000 --> 00:01:27,600 MINUTES SHOULD EXISTING YOUR 31 00:01:27,600 --> 00:01:32,200 ELECTRONIC COUNCIL BOOK. ARE 32 00:01:32,200 --> 00:01:32,680 THERE ANY COMMENTS, OR 33 00:01:32,680 --> 00:01:35,200 QUESTIONS OR CONCERNS ABOUT THE 34 00:01:35,200 --> 00:01:35,840 MINUTES? ANYBODY WORRIED ABOUT 35 00:01:35,840 --> 00:01:36,440 CONCEPT THAT WE APPROVED THE 36 00:01:36,440 --> 00:01:39,120 LAST SESSION? HEARING NO 37 00:01:39,120 --> 00:01:39,760 CONCERNS CAN I HAVE A MOTION TO 38 00:01:39,760 --> 00:01:42,480 APPROVE THE MINUTES? SO MOVED. 39 00:01:42,480 --> 00:01:45,520 SECOND. ALL IN FAVOR? 40 00:01:45,520 --> 00:01:52,200 >>AYE. 41 00:01:52,200 --> 00:01:52,800 >>ALL OPPOSED THE MINUTES ARE 42 00:01:52,800 --> 00:01:57,360 APPROVED AS WRITTEN. 43 00:01:57,360 --> 00:01:59,960 MOVING ON TO THE REMARKS, THIS 44 00:01:59,960 --> 00:02:02,160 IS A SLIDE PUT INTO TEASE ME. 45 00:02:02,160 --> 00:02:05,000 I THINK YOU ALL KNOW THAT NIH 46 00:02:05,000 --> 00:02:05,560 IS LOOKING FOR A PERMANENT 47 00:02:05,560 --> 00:02:16,040 DIRECTOR FOR NIAID, VACANCY 48 00:02:23,360 --> 00:02:23,840 ANNOUNCEMENT WENT OUT ON 49 00:02:23,840 --> 00:02:24,440 NOVEMBER 16 AND APPLICATIONS 50 00:02:24,440 --> 00:02:25,360 CLOSED ON GENEROUS SEVENTEENTH 51 00:02:25,360 --> 00:02:26,000 IN THE SEARCH COMMITTEE WORKED 52 00:02:26,000 --> 00:02:33,640 IN RECORD SPEED. KEITH FORMED A 53 00:02:33,640 --> 00:02:37,120 GROUP AT NIH TO HAVE A SECOND 54 00:02:37,120 --> 00:02:37,720 LEVEL OF INTERVIEWS I DO NOT 55 00:02:37,720 --> 00:02:38,440 KNOW WHERE IT IS GOING TO END. 56 00:02:38,440 --> 00:02:44,000 I TOLD NIH THAT I WAS PLANNING 57 00:02:44,000 --> 00:02:44,520 TO STEP DOWN FROM FEDERAL 58 00:02:44,520 --> 00:02:47,760 SERVICE ON DECEMBER 31, OF THIS 59 00:02:47,760 --> 00:02:48,400 YEAR BUT I ALSO SAID REPEATEDLY 60 00:02:48,400 --> 00:02:49,160 THAT I WOULD OFFER A NEW 61 00:02:49,160 --> 00:02:50,920 DIRECTOR SIX MONTHS THAT I 62 00:02:50,920 --> 00:02:52,440 WOULD SERVE IF THEY WANTED AS 63 00:02:52,440 --> 00:03:01,080 PRINCIPAL DEPUTY DIRECTOR. IF 64 00:03:01,080 --> 00:03:01,640 THE MEETING WOULD LOOK LIKE 65 00:03:01,640 --> 00:03:02,800 THIS, THE TWO THINGS MAY BE IN 66 00:03:02,800 --> 00:03:06,360 CONFLICT. IN ANY CASE FOR SIX 67 00:03:06,360 --> 00:03:12,600 MONTHS SO STAY TUNED. 68 00:03:12,600 --> 00:03:13,200 ANNOUNCEMENTS TO OTHER PEOPLE 69 00:03:13,200 --> 00:03:13,800 TO POSITIONS YOU'RE PROBABLY 70 00:03:13,800 --> 00:03:14,400 AWARE THAT THE PRESIDENT HAS 71 00:03:14,400 --> 00:03:15,000 NOMINATED MONICA BERTINELLI 72 00:03:15,000 --> 00:03:16,960 (PHONETIC) AS A FUTURE NIH 73 00:03:16,960 --> 00:03:20,080 DIRECTOR AND FOR THE PAST EIGHT 74 00:03:20,080 --> 00:03:20,800 MONTHS SHE HAS BEEN DIRECTOR OF 75 00:03:20,800 --> 00:03:25,000 THE NATIONAL CANCER INSTITUTE. 76 00:03:25,000 --> 00:03:25,520 THAT IS A PRESIDENTIAL 77 00:03:25,520 --> 00:03:26,080 APPOINTMENT BUT IT DOES NOT 78 00:03:26,080 --> 00:03:28,360 REQUIRE SENATE CONFIRMATION. 79 00:03:28,360 --> 00:03:32,040 THE JOB OF THE NIH DOES AND I 80 00:03:32,040 --> 00:03:38,000 WILL ADJUST TO MONICA LAST 81 00:03:38,000 --> 00:03:38,600 WEEK. MANY OF THE THINGS SHE 82 00:03:38,600 --> 00:03:39,760 WILL BE CROSS INTERROGATED CAN 83 00:03:39,760 --> 00:03:43,600 DIRECT YOU FROM THE NIAID, AND 84 00:03:43,600 --> 00:03:45,200 SHE'S AN ABSOLUTELY DELIGHTFUL 85 00:03:45,200 --> 00:03:45,800 PERSON. WE HAVE HAD A LOT OF 86 00:03:45,800 --> 00:03:46,440 FUN WITH HER FOR THE LAST EIGHT 87 00:03:46,440 --> 00:03:50,280 MONTHS. 88 00:03:50,280 --> 00:03:54,040 LET ME ALSO SAY, SHE'S GOING 89 00:03:54,040 --> 00:03:54,640 TO BE A LITTLE BIT DIFFERENT 90 00:03:54,640 --> 00:03:57,880 FROM PREVIOUS NIH DIRECTORS 91 00:03:57,880 --> 00:04:03,240 BECAUSE SHE IS A SURGEON-- 92 00:04:03,240 --> 00:04:03,880 NOTHING AGAINST SURGEONS-- BUT 93 00:04:03,880 --> 00:04:04,400 SHE PRIMARILY KNOWN AS A 94 00:04:04,400 --> 00:04:04,960 CLINICAL RESEARCHER IN HER 95 00:04:04,960 --> 00:04:05,480 ACADEMIC WORK, WHICH IS 96 00:04:05,480 --> 00:04:08,080 SOMEWHAT DIFFERENT FROM 97 00:04:08,080 --> 00:04:08,680 PREVIOUS NIH DIRECTORS AND I 98 00:04:08,680 --> 00:04:09,240 ACTUALLY THINK IT IS A GOOD 99 00:04:09,240 --> 00:04:13,360 TIME IN THE HISTORY OF THE NIH 100 00:04:13,360 --> 00:04:14,520 TO HAVE THAT KIND OF 101 00:04:14,520 --> 00:04:15,000 PERSPECTIVE IN THE TOP 102 00:04:15,000 --> 00:04:18,920 LEADERSHIP POSITION. 103 00:04:18,920 --> 00:04:19,520 NOW, WHICH IS CONFIRMED ASSUME 104 00:04:19,520 --> 00:04:20,160 SHE IS CONFIRMED THAT WILL FREE 105 00:04:20,160 --> 00:04:25,080 UP LARRY TADEBACK (PHONETIC) TO 106 00:04:25,080 --> 00:04:29,480 STEP DOWN FROM ACTING NIH AND I 107 00:04:29,480 --> 00:04:30,080 THINK HE IS EAGER TO LEAVE AT 108 00:04:30,080 --> 00:04:32,640 THE FIRST OPPORTUNITY. IF YOU 109 00:04:32,640 --> 00:04:34,520 ADD TOGETHER THE TIME THAT 110 00:04:34,520 --> 00:04:37,360 LARRY WAS THE ACTING PRINCIPAL 111 00:04:37,360 --> 00:04:38,520 DEPUTY PLUS THE TIME THAT HE 112 00:04:38,520 --> 00:04:40,280 WAS THE PRINCIPAL DEPUTY, PLUS 113 00:04:40,280 --> 00:04:40,920 THE TIME THAT HE HAS BEEN THE 114 00:04:40,920 --> 00:04:43,760 ACTING DIRECTOR OF NIH, HE 115 00:04:43,760 --> 00:04:45,320 ACTUALLY HAS MORE YEARS OF 116 00:04:45,320 --> 00:04:50,200 SENIOR SERVICE IN BUILDING 1 117 00:04:50,200 --> 00:04:50,800 THAN ANY OTHER PATIENT IN THE 118 00:04:50,800 --> 00:04:51,520 HISTORY OF THE NATIONAL 119 00:04:51,520 --> 00:04:55,480 INSTITUTES OF HEALTH. HE HAS 120 00:04:55,480 --> 00:04:56,000 DEVOTED HIMSELF TO THE 121 00:04:56,000 --> 00:04:58,080 WELL-BEING OF SCIENCE IN THIS 122 00:04:58,080 --> 00:04:58,480 COUNTRY. 123 00:04:58,480 --> 00:05:01,000 NOW, ANOTHER BOSTON WOMAN 124 00:05:01,000 --> 00:05:06,440 ROCHELLE WALENSKY IS STEPPING 125 00:05:06,440 --> 00:05:07,040 DOWN AT THE END OF THIS MONTH 126 00:05:07,040 --> 00:05:10,280 FROM THE CDC WHERE SHE HAS BEEN 127 00:05:10,280 --> 00:05:14,320 FOR TWO YEARS, TO VERY 128 00:05:14,320 --> 00:05:14,880 DIFFICULT YEARS AND SHE IS 129 00:05:14,880 --> 00:05:15,360 LOOKING FORWARD TO THE 130 00:05:15,360 --> 00:05:17,720 OPPORTUNITY TO STEP DOWN. THIS 131 00:05:17,720 --> 00:05:18,360 IS NOT AN OFFICIAL ANNOUNCEMENT 132 00:05:18,360 --> 00:05:22,440 BECAUSE THE PRESIDENT IS NOT 133 00:05:22,440 --> 00:05:27,680 NOMINATED ANDY COHEN BUT WE 134 00:05:27,680 --> 00:05:28,280 HAVE READ THAT IN THE PAPERS 135 00:05:28,280 --> 00:05:28,880 THAT HE THINK HE IS GOING TO 136 00:05:28,880 --> 00:05:33,960 RECOMMEND MANDY COHEN TO THE 137 00:05:33,960 --> 00:05:34,600 DCD SLOT AND SHE SPENT A NUMBER 138 00:05:34,600 --> 00:05:35,240 OF YEARS AS THE SEC. OF HEALTH 139 00:05:35,240 --> 00:05:39,800 AND HUMAN SERVICES NORTH 140 00:05:39,800 --> 00:05:40,440 CAROLINA. BEFORE THAT SHE SPENT 141 00:05:40,440 --> 00:05:40,920 MANY YEARS IN THE OBAMA 142 00:05:40,920 --> 00:05:43,480 MENSTRUATION AND SHE IS 143 00:05:43,480 --> 00:05:44,040 WELL-CONNECTED. I THINK SHE 144 00:05:44,040 --> 00:05:44,680 WOULD BE A GREAT CANDIDATE FOR 145 00:05:44,680 --> 00:05:45,320 THIS POSITION BUT THAT IS NOT 146 00:05:45,320 --> 00:05:47,240 OFFICIAL YET. AND THEN WE HAVE 147 00:05:47,240 --> 00:05:49,160 KARINA WALTERS WHO IS STEPPING 148 00:05:49,160 --> 00:05:49,760 IN TO THE POSITION OF TRIBAL 149 00:05:49,760 --> 00:05:52,960 HEALTH RESEARCH OFFICE. WE WORK 150 00:05:52,960 --> 00:05:54,520 CLOSELY WITH HIS OFFICE IN THE 151 00:05:54,520 --> 00:05:56,880 PAST WHICH HAS BEEN VERY USEFUL 152 00:05:56,880 --> 00:05:57,480 TO US IN DEVELOPING RELATIONS 153 00:05:57,480 --> 00:06:02,440 WITH THE TRIBAL COUNCILS, 154 00:06:02,440 --> 00:06:03,040 MAKING IT POSSIBLE TO INVOLVE 155 00:06:03,040 --> 00:06:03,600 NATIVE AMERICANS IN OUR 156 00:06:03,600 --> 00:06:04,840 CLINICAL TRIALS IN SOME OF OUR 157 00:06:04,840 --> 00:06:05,920 CLINICAL STUDIES. 158 00:06:05,920 --> 00:06:10,760 EXCEPT FOR LARRY TADEBACK 159 00:06:10,760 --> 00:06:11,360 EVERYBODY THAT I TALKED ABOUT 160 00:06:11,360 --> 00:06:19,360 SO FAR IS A WOMAN. WE WILL COME 161 00:06:19,360 --> 00:06:19,960 BACK TO THAT THINGS ARE MORE 162 00:06:19,960 --> 00:06:20,640 DURING THE COURSE OF THE 163 00:06:20,640 --> 00:06:21,160 MORNING. BUT I DO WANT TO 164 00:06:21,160 --> 00:06:23,000 MENTION THE JOHN GALLAND 165 00:06:23,000 --> 00:06:23,600 (PHONETIC) HAS RETIRED OR HAS 166 00:06:23,600 --> 00:06:24,160 RETIRED AND IN ADDITION TO 167 00:06:24,160 --> 00:06:24,800 BEING AN OUTSTANDING SCIENTIST 168 00:06:24,800 --> 00:06:28,720 HE HAS SERVED NIH AND NIAID, HE 169 00:06:28,720 --> 00:06:29,200 HAS BEEN THE SCIENTIFIC 170 00:06:29,200 --> 00:06:32,240 DIRECTOR FOR NIAID AND THE 171 00:06:32,240 --> 00:06:34,440 LONGEST SERVING DIR. FOR THE 172 00:06:34,440 --> 00:06:36,160 CLINICAL CENTER IN THE HISTORY 173 00:06:36,160 --> 00:06:40,480 OF NIH. HE IS ALSO A GOOD 174 00:06:40,480 --> 00:06:41,080 FRIEND AND A COLLEAGUE FOR MANY 175 00:06:41,080 --> 00:06:44,800 OF US. 176 00:06:44,800 --> 00:06:50,440 MONICA GOODENOW, OFFICE OF 177 00:06:50,440 --> 00:06:51,080 AIDS RESEARCH HAS STEPPED DOWN 178 00:06:51,080 --> 00:06:52,360 AND THE ACTING DIRECTOR OF OAR 179 00:06:52,360 --> 00:06:57,440 IS BILL -- BILL HAS BEEN IN THE 180 00:06:57,440 --> 00:06:58,080 CHILD HEALTH INSTITUTE FOR MANY 181 00:06:58,080 --> 00:07:01,600 YEARS AND IS WORKED WITH NIAID 182 00:07:01,600 --> 00:07:02,400 STAFF AND HE HAS BEEN 183 00:07:02,400 --> 00:07:02,920 PARTICULARLY ACTIVE IN 184 00:07:02,920 --> 00:07:07,480 ADOLESCENT HIV TRIALS. WE KNOW 185 00:07:07,480 --> 00:07:08,120 HIM WELL IN THE THINK IS GOING 186 00:07:08,120 --> 00:07:10,080 TO BE A TERRIFIC PERSON IN THAT 187 00:07:10,080 --> 00:07:13,280 OFFICE FOR US. 188 00:07:13,280 --> 00:07:16,520 JEREMY FERRAR (PHONETIC) IS 189 00:07:16,520 --> 00:07:17,080 NOT BEEN NAMED AS THE CHIEF 190 00:07:17,080 --> 00:07:19,520 SCIENTIST FOR WHO AND SOME OF 191 00:07:19,520 --> 00:07:25,320 THE NIAID HAVE WORK WITH OR 192 00:07:25,320 --> 00:07:26,560 ALONGSIDE JEREMY FOR SEVERAL 193 00:07:26,560 --> 00:07:27,160 DECADES, PARTICULARLY DURING 194 00:07:27,160 --> 00:07:27,760 THE PAST 10 YEARS WHEN HE HAS 195 00:07:27,760 --> 00:07:30,840 BEEN THE DIRECTOR OF THE 196 00:07:30,840 --> 00:07:34,040 WELLCOME TRUST. 197 00:07:34,040 --> 00:07:34,520 IMMEDIATELY AFTER HIS 198 00:07:34,520 --> 00:07:35,120 APPOINTMENT WAS ANNOUNCED, HE 199 00:07:35,120 --> 00:07:38,640 CAME TO VISIT US AT NIAID AND I 200 00:07:38,640 --> 00:07:39,240 THINK WE HAD A REALLY GOOD 201 00:07:39,240 --> 00:07:41,640 CONVERSATION WITH MANY FOR 202 00:07:41,640 --> 00:07:42,200 SENIOR STAFF WITH HIM SO I 203 00:07:42,200 --> 00:07:42,760 THINK THIS IS GOING TO BE A 204 00:07:42,760 --> 00:07:43,360 VERY GOOD RELATIONSHIP IN THE 205 00:07:43,360 --> 00:07:46,120 FUTURE. 206 00:07:46,120 --> 00:07:48,280 I'M SAD TO REPORT THAT ED -- 207 00:07:48,280 --> 00:07:54,720 DIED IN MARCH. ED WITH THE 208 00:07:54,720 --> 00:07:55,320 DIRECTOR OF THE DIVISION OF 209 00:07:55,320 --> 00:07:55,920 AIDS WHEN I ARRIVED HERE AND 210 00:07:55,920 --> 00:07:56,520 MORE RECENTLY HE HAS BEEN THE 211 00:07:56,520 --> 00:07:58,160 ASSOCIATE DIRECTOR OF CLINICAL 212 00:07:58,160 --> 00:07:58,760 RESEARCH IN THE DIVISION OF 213 00:07:58,760 --> 00:08:00,280 CLINICAL RESEARCH. 214 00:08:00,280 --> 00:08:03,960 WHEN I FIRST GOT HERE, ED 215 00:08:03,960 --> 00:08:06,720 SPENT HOURS TRYING TO TEACH ME 216 00:08:06,720 --> 00:08:07,240 ABOUT THE INTRICACIES OF 217 00:08:07,240 --> 00:08:10,400 INTERNATIONAL RESEARCH ON HIV. 218 00:08:10,400 --> 00:08:12,360 AND EVEN JUST A WEEK BEFORE HE 219 00:08:12,360 --> 00:08:12,960 DIED, HE CALLED ME UP TO MAKE 220 00:08:12,960 --> 00:08:14,960 SURE I KNEW THAT HE WAS 221 00:08:14,960 --> 00:08:18,120 AVAILABLE TO SUPPORT AND ADVICE 222 00:08:18,120 --> 00:08:18,680 IN THIS POSITION AS ACTING 223 00:08:18,680 --> 00:08:22,440 DIRECTOR. HE WAS A VERY 224 00:08:22,440 --> 00:08:24,920 GENEROUS MAN. 225 00:08:24,920 --> 00:08:27,640 WE ARE DELIGHTED THAT TED 226 00:08:27,640 --> 00:08:28,240 PEARSON IS NOW OFFICIALLY THE 227 00:08:28,240 --> 00:08:30,080 DIRECTOR OF THE VACCINE 228 00:08:30,080 --> 00:08:30,680 RESEARCH CENTER. I THINK THE 229 00:08:30,680 --> 00:08:41,160 LAST OFFICIAL ACT THAT TONY 230 00:08:47,720 --> 00:08:48,240 FAUCI DID AS A DIRECTOR VISIT 231 00:08:48,240 --> 00:08:49,280 TO ASK TED TO TAKE HIS POSITION 232 00:08:49,280 --> 00:08:49,880 AND HE ASKED HIM TO TAKE THIS 233 00:08:49,880 --> 00:08:50,480 JOB AT THE INTRAMURAL PROGRAM 234 00:08:50,480 --> 00:08:51,680 LABORATORY CHIEF, FAMOUS 235 00:08:51,680 --> 00:08:52,280 BECAUSE HE WAS DEVOTED TO THE 236 00:08:52,280 --> 00:08:53,120 YOUNGER PEOPLE IN HIS LAB. I AM 237 00:08:53,120 --> 00:08:53,760 SURE THAT IS A TRADITION HE IS 238 00:08:53,760 --> 00:08:58,440 GOING TO CONTINUE. HIS 239 00:08:58,440 --> 00:09:05,160 APPOINTMENT THEN FREEZES UP 240 00:09:05,160 --> 00:09:07,120 RICK KELP (PHONETIC) WITH ONE 241 00:09:07,120 --> 00:09:08,640 ANOTHER TO DO WITH DIRECTOR OF 242 00:09:08,640 --> 00:09:12,320 THE BRC, BUT HE DID A BEAUTIFUL 243 00:09:12,320 --> 00:09:12,960 JOB AND NOW HE WILL RETURN TO 244 00:09:12,960 --> 00:09:14,200 BEING THE DEPUTY DIRECTOR. 245 00:09:14,200 --> 00:09:15,880 GARY NABEL AND JOHN -- AND 246 00:09:15,880 --> 00:09:20,760 RICK -- THERE IS INCREDIBLE 247 00:09:20,760 --> 00:09:25,160 TALENT OVER IN THE BRC. IT WAS 248 00:09:25,160 --> 00:09:25,760 A PLEASURE TO WORK WITH RICK 249 00:09:25,760 --> 00:09:26,360 DURING THE TIME THAT HE WAS 250 00:09:26,360 --> 00:09:27,360 ACTING DIRECTOR. 251 00:09:27,360 --> 00:09:32,640 JOHANNES SCHNEIDER (PHONETIC) 252 00:09:32,640 --> 00:09:33,280 HAS BEEN NAMED THE DIRECTOR OF 253 00:09:33,280 --> 00:09:33,760 THE OFFICE OF STRATEGIC 254 00:09:33,760 --> 00:09:34,280 PLANNING AT INITIATIVE 255 00:09:34,280 --> 00:09:40,200 DEVELOPMENT LAB ANALYSIS OR 256 00:09:40,200 --> 00:09:40,800 SPIDA AS WE CALL IT THE NIGHT 257 00:09:40,800 --> 00:09:41,880 HAVE BEEN HERE FOR 17 YEARS AND 258 00:09:41,880 --> 00:09:42,440 IT HAS NEVER BEEN ENTIRELY 259 00:09:42,440 --> 00:09:45,200 CLEAR WHAT SPIDA DOES, ALTHOUGH 260 00:09:45,200 --> 00:09:46,680 I KNOW IT DOES LOTS OF THINGS. 261 00:09:46,680 --> 00:09:49,400 I THINK THAT THE STRATEGIC 262 00:09:49,400 --> 00:09:50,560 PLANNING ASPECT OF IT MEANS 263 00:09:50,560 --> 00:09:52,480 THAT THIS OFFICE IS 264 00:09:52,480 --> 00:09:54,440 INTERSECTION WITH MANY OTHER 265 00:09:54,440 --> 00:09:56,640 PARTS OF THE NIH, AND INDEED 266 00:09:56,640 --> 00:09:58,880 WITH THE FEDERAL GOVERNMENT. 267 00:09:58,880 --> 00:10:00,080 SO IT REALLY IS A BIG DEAL, 268 00:10:00,080 --> 00:10:02,280 THIS OFFICE. 269 00:10:02,280 --> 00:10:07,040 TO PUT IT THIS WAY, ON MY CC 270 00:10:07,040 --> 00:10:07,640 LINE FOR EMAILS THAT I WRITE 271 00:10:07,640 --> 00:10:11,000 IS ACTING DIRECTOR, THE FOUR 272 00:10:11,000 --> 00:10:11,560 MOST COMMON NAMES ARE JOE 273 00:10:11,560 --> 00:10:13,080 HARPER IS A DEPUTY DIRECTOR FOR 274 00:10:13,080 --> 00:10:14,600 SCIENCE MANAGEMENT, JOHANNA 275 00:10:14,600 --> 00:10:20,160 SCHNEIDER, COURTNEY MILLET 276 00:10:20,160 --> 00:10:20,680 (PHONETIC) AS DIRECTOR OF 277 00:10:20,680 --> 00:10:21,240 COMMUNICATION THAT MELINDA 278 00:10:21,240 --> 00:10:23,360 HASKINS LEGISLATIVE OFFICE. 279 00:10:23,360 --> 00:10:23,960 DID I MENTION THAT THEY WERE 280 00:10:23,960 --> 00:10:26,640 ALL WOMEN? 281 00:10:26,640 --> 00:10:28,480 JANET MCNICHOL HAS JOINED US 282 00:10:28,480 --> 00:10:32,720 AS THE CHIEF OF THE DAYS 283 00:10:32,720 --> 00:10:33,280 VACCINE CLINICAL RESEARCH 284 00:10:33,280 --> 00:10:36,240 BRANCH AND SHE COMES TO US 285 00:10:36,240 --> 00:10:36,840 AFTER MANY DECADES AT THE CDC 286 00:10:36,840 --> 00:10:38,080 AND SOMEHOW WE ATTRACTED HER 287 00:10:38,080 --> 00:10:39,160 AWAY. 288 00:10:39,160 --> 00:10:42,920 AND ROGER PECK (PHONETIC) HAS 289 00:10:42,920 --> 00:10:47,360 JOINED DAYS IN THE DRUG 290 00:10:47,360 --> 00:10:47,920 DEVELOPMENT AND CLINICAL 291 00:10:47,920 --> 00:10:51,080 RESEARCH BRANCH AND COMES TO US 292 00:10:51,080 --> 00:10:51,600 AFTER 30 YEARS IN PRIVATE 293 00:10:51,600 --> 00:10:53,120 INDUSTRY MANAGING HIV TRIALS, 294 00:10:53,120 --> 00:10:55,200 AND HIV RESEARCH PROGRAMS. 295 00:10:55,200 --> 00:10:57,040 RUTH WOODWARD STEPPING DOWN AS 296 00:10:57,040 --> 00:10:59,680 THE CHIEF OF THE BRC 297 00:10:59,680 --> 00:11:05,120 TRANSLATIONAL SCIENCES PROGRAM. 298 00:11:05,120 --> 00:11:05,720 SHE HAS HAD MANY YEARS AS AN 299 00:11:05,720 --> 00:11:06,320 EXPERT WORKING WITH NONHUMAN 300 00:11:06,320 --> 00:11:07,400 PRIMATES. 301 00:11:07,400 --> 00:11:07,960 NOW WE ARE GOING TO MOVE TO 302 00:11:07,960 --> 00:11:12,800 SOME AWARDS, DANNY -- BEEN 303 00:11:12,800 --> 00:11:13,440 ELECTED FELLOW OF THE AMERICAN 304 00:11:13,440 --> 00:11:15,200 ACADEMY OF MICROBIOLOGY. THIS 305 00:11:15,200 --> 00:11:18,480 IS HOW DANNY ACTUALLY LOOKS. 306 00:11:18,480 --> 00:11:19,440 YESTERDAY OR TWO DAYS AGO I SAT 307 00:11:19,440 --> 00:11:21,880 AT A TABLE WITH DANNY. HE WAS 308 00:11:21,880 --> 00:11:23,920 WEARING A SUIT, AND WAS CLEANLY 309 00:11:23,920 --> 00:11:26,280 SHAVEN. I DID NOT RECOGNIZE WHO 310 00:11:26,280 --> 00:11:35,400 HE WAS. LUIGI NOTORLENZO 311 00:11:35,400 --> 00:11:38,960 (PHONETIC) HAS BEEN ELECTED 312 00:11:38,960 --> 00:11:39,480 DIRECTOR OF THE AMERICAN 313 00:11:39,480 --> 00:11:44,200 ACADEMY OF PHYSICIANS AND -- 314 00:11:44,200 --> 00:11:44,840 HAS BEEN ELECTED AS DIRECTOR OF 315 00:11:44,840 --> 00:11:45,400 THE ACADEMY OF SCIENCES AND 316 00:11:45,400 --> 00:11:50,320 JASMINE -- WILL BE APPOINTED AS 317 00:11:50,320 --> 00:11:55,480 DIRECTOR OF THE INSTITUTE 318 00:11:55,480 --> 00:11:56,040 PASTEUR, OF COURSE WE WERE 319 00:11:56,040 --> 00:11:58,440 DISAPPOINTED TO LOSE A STAR IN 320 00:11:58,440 --> 00:12:04,400 THE INTRAMURAL PROGRAM, AND SHE 321 00:12:04,400 --> 00:12:05,000 HAS BEEN THAT FOR MANY YEARS 322 00:12:05,000 --> 00:12:05,760 BUT WHAT A TERRIFIC OPPORTUNITY 323 00:12:05,760 --> 00:12:06,400 FOR HER AND HER NATIVE FRANCE, 324 00:12:06,400 --> 00:12:07,040 IT IS AN OPPORTUNITY FOR US TO 325 00:12:07,040 --> 00:12:07,640 MAINTAIN COLLABORATIONS WITH 326 00:12:07,640 --> 00:12:08,840 THE INSTITUTE PASTEUR IN THE 327 00:12:08,840 --> 00:12:09,440 FUTURE AND NOW THIS IS TO THE 328 00:12:09,440 --> 00:12:12,360 NIH AND THE NIAID. 329 00:12:12,360 --> 00:12:12,920 WE WERE THRILLED TO HAVE AN 330 00:12:12,920 --> 00:12:15,880 AFTERNOON WHEN -- THE WHITE 331 00:12:15,880 --> 00:12:18,960 HOUSE WERE NEEDED FOR COVID 332 00:12:18,960 --> 00:12:21,400 RESPONSE SPENT AN AFTERNOON AT 333 00:12:21,400 --> 00:12:24,320 THE NIH LEARNING ABOUT WHAT WE 334 00:12:24,320 --> 00:12:25,040 DO AND WE KNEW WHEN HE CAME 335 00:12:25,040 --> 00:12:25,760 HERE THAT HE WAS DEVELOPING IN 336 00:12:25,760 --> 00:12:27,200 HIS MIND WHAT HAS NOW BEEN 337 00:12:27,200 --> 00:12:34,600 CALLED PROJECT NEXTGEN. THIS 338 00:12:34,600 --> 00:12:35,200 GIVES AN OPPORTUNITY TO PRESENT 339 00:12:35,200 --> 00:12:36,200 WHAT WE THOUGHT WE COULD OFFER 340 00:12:36,200 --> 00:12:36,800 THAT PROGRAM ESPECIALLY IN THE 341 00:12:36,800 --> 00:12:40,240 WAY OF VACCINE STUDIES IN THE 342 00:12:40,240 --> 00:12:40,880 FUTURE, BOTH TO DEVELOP BROADER 343 00:12:40,880 --> 00:12:43,960 VACCINES, AND ALSO PERHAPS 344 00:12:43,960 --> 00:12:45,840 ACHIEVE MUCOSAL PROTECTION. 345 00:12:45,840 --> 00:12:52,800 HERE, KAREEM BOCK, (PHONETIC), 346 00:12:52,800 --> 00:12:57,720 TED PEARSON, ASISHA, LARRY 347 00:12:57,720 --> 00:13:01,760 TADEBACK -- HOW DO NOT END UP 348 00:13:01,760 --> 00:13:03,600 IN THE PICTURE? YOU ARE AT THIS 349 00:13:03,600 --> 00:13:09,320 MEETING. EVEN WITH DOCTOR 350 00:13:09,320 --> 00:13:09,840 FAUCI JOHN OTHER FOREIGN 351 00:13:09,840 --> 00:13:13,360 VISITORS COME TO SEE US. THE 352 00:13:13,360 --> 00:13:13,960 PRESIDENT OF THE JAPAN AGENCY 353 00:13:13,960 --> 00:13:17,800 FOR MEDICAL RESEARCH AND 354 00:13:17,800 --> 00:13:18,400 DEVELOPMENT, THE MINISTER OF 355 00:13:18,400 --> 00:13:19,000 HIGHER EDUCATION AND SCIENCE 356 00:13:19,000 --> 00:13:19,640 INNOVATION FROM SOUTH AFRICA, 357 00:13:19,640 --> 00:13:20,200 AND THIS WAS A FASCINATING 358 00:13:20,200 --> 00:13:24,160 VISIT FROM DEMETRI BUTTOW 359 00:13:24,160 --> 00:13:24,800 (PHONETIC) FROM UKRAINE WHO HAS 360 00:13:24,800 --> 00:13:28,480 BEEN CONCLUDING TO OUR TD 361 00:13:28,480 --> 00:13:29,040 PORTAL DOING RESEARCH EVEN 362 00:13:29,040 --> 00:13:30,400 THOUGH HE IS WITHIN THE SOUND 363 00:13:30,400 --> 00:13:33,880 OF THE WAR IN HIS COUNTRY. HE 364 00:13:33,880 --> 00:13:34,400 HAS BEEN ONE OF THE MOST 365 00:13:34,400 --> 00:13:42,400 PRODUCTIVE OF OUR TB 366 00:13:42,400 --> 00:13:44,320 INVESTIGATORS ABROAD. 367 00:13:44,320 --> 00:13:44,880 WE ALSO HAVE SPECIAL CONTACT 368 00:13:44,880 --> 00:13:48,640 WITH DOCTOR -- DIRECTOR GENERAL 369 00:13:48,640 --> 00:13:49,160 OF THE INDIAN COUNCIL OF 370 00:13:49,160 --> 00:13:49,800 MEDICAL RESEARCH AND WE HAD A 371 00:13:49,800 --> 00:13:51,200 LONG PRODUCTIVE ZOOM 372 00:13:51,200 --> 00:13:54,520 CONVERSATION WITH HIM. AND 373 00:13:54,520 --> 00:13:55,080 THEN JUST LAST FRIDAY I HAD 374 00:13:55,080 --> 00:13:56,920 DINNER ALONG WITH OTHERS WITH 375 00:13:56,920 --> 00:13:59,800 DR. -- -- THE SECRETARY OF THE 376 00:13:59,800 --> 00:14:02,440 DEPARTMENT OF BIOTECHNOLOGY FOR 377 00:14:02,440 --> 00:14:04,120 THE GOVERNMENT OF INDIA. THESE 378 00:14:04,120 --> 00:14:05,680 ARE THE TWO HIGHEST RANKING 379 00:14:05,680 --> 00:14:06,280 PEOPLE IN BIOMEDICAL RESEARCH 380 00:14:06,280 --> 00:14:10,200 IN INDIA. AND THINK IT SPEAKS 381 00:14:10,200 --> 00:14:10,840 WELL OF OUR FUTURE RELATIONSHIP 382 00:14:10,840 --> 00:14:12,600 WITH HIS COUNTRY. 383 00:14:12,600 --> 00:14:13,800 WE HAVE HAD THE VACCINE ACTION 384 00:14:13,800 --> 00:14:19,040 PROGRAM, SO-CALLED VAP, NOW IN 385 00:14:19,040 --> 00:14:20,560 HIS 36 YEAR AND DOCTOR FAUCI 386 00:14:20,560 --> 00:14:24,440 AND DOCTOR-- SIGNED A FIVE-YEAR 387 00:14:24,440 --> 00:14:28,880 EXTENSION SHORTER BEFORE DOCTOR 388 00:14:28,880 --> 00:14:32,280 FAUCI STEP DOWN. 389 00:14:32,280 --> 00:14:32,880 THESE ARE THE TOP 10 CLINICAL 390 00:14:32,880 --> 00:14:34,720 RESEARCH AWARDS PRESENTED TO 391 00:14:34,720 --> 00:14:35,320 PETER -- FROM THE INTRAMURAL 392 00:14:35,320 --> 00:14:36,720 PROGRAM AND I WILL COME BACK TO 393 00:14:36,720 --> 00:14:47,240 THIS. IT WAS FOR THE SAFETY AND 394 00:14:47,240 --> 00:14:48,360 EFFICACY OF MONOCLONAL ANTIBODY 395 00:14:48,360 --> 00:14:49,000 AGAINST MALARIA IN MALI, AND IS 396 00:14:49,000 --> 00:14:49,480 A SETTABLE COME BACK TO 397 00:14:49,480 --> 00:14:50,120 MENTIONING THIS IN THE FUTURE. 398 00:14:50,120 --> 00:14:50,800 ALSO WANT TO MENTION THAT NIH 399 00:14:50,800 --> 00:14:51,960 HAS RELEASED A STRATEGIC PLAN 400 00:14:51,960 --> 00:14:54,800 FOR DTIA, THE BROADER STRATEGIC 401 00:14:54,800 --> 00:15:01,200 PLAN FOR NIH'S HOME. 402 00:15:01,200 --> 00:15:05,440 AND NOW THE BUDGET UPDATE. 403 00:15:05,440 --> 00:15:06,040 FIRST OF ALL THIS IS HISTORY 404 00:15:06,040 --> 00:15:10,600 ALSO. THE TOP PEOPLE IN 405 00:15:10,600 --> 00:15:11,160 APPROPRIATING FUNDS AT THIS 406 00:15:11,160 --> 00:15:17,600 POINT ARE ALL WOMEN. SUSAN 407 00:15:17,600 --> 00:15:20,600 COLLINS, PATTY MURRAY, ASHANDRA 408 00:15:20,600 --> 00:15:26,320 -- AND ROSA DOLORA (PHONETIC). 409 00:15:26,320 --> 00:15:33,480 ASHANDRA YOUNG (PHONETIC) IS 410 00:15:33,480 --> 00:15:34,080 THE DIRECTOR OF THE OFFICE OF 411 00:15:34,080 --> 00:15:34,680 MANAGEMENT AND BUDGET AND IF 412 00:15:34,680 --> 00:15:35,280 YOU HAVE BEEN FOLLOWING THE 413 00:15:35,280 --> 00:15:35,880 PAPERS SHE IS ONE OF THE TWO OR 414 00:15:35,880 --> 00:15:37,080 THREE PEOPLE MOST LIKELY 415 00:15:37,080 --> 00:15:37,680 INVOLVED IN THE BUDGET CEILING 416 00:15:37,680 --> 00:15:41,120 NEGOTIATIONS. 417 00:15:41,120 --> 00:15:41,720 THIS IS THE BUDGET THAT WE ARE 418 00:15:41,720 --> 00:15:50,760 NOW WORKING UNDER FOR THIS YEAR. 419 00:15:50,760 --> 00:15:51,280 I FOUND IT A LITTLE BIT 420 00:15:51,280 --> 00:15:51,800 IRRITATING THAT WE WERE 421 00:15:51,800 --> 00:15:54,440 ACTUALLY HAVE A SMALLER 422 00:15:54,440 --> 00:15:56,800 INCREASE THAN MANY OTHER 423 00:15:56,800 --> 00:15:57,400 INTRODUCED DESPITE THE FACT 424 00:15:57,400 --> 00:15:57,920 THAT WE ARE THE PANDEMIC 425 00:15:57,920 --> 00:16:03,120 PREPAREDNESS INSTITUTE. HOW CAN 426 00:16:03,120 --> 00:16:03,680 WE NOT THINK ABOUT PANDEMIC 427 00:16:03,680 --> 00:16:06,640 FAIRNESS AS WE COME OFF A 428 00:16:06,640 --> 00:16:07,280 HISTORIC PANDEMIC FOR THE LAST 429 00:16:07,280 --> 00:16:08,120 SEVERAL YEARS? 430 00:16:08,120 --> 00:16:08,640 AS THIS BUDGET WAS BEING 431 00:16:08,640 --> 00:16:10,520 DEVELOPED THERE WERE TIMES WHEN 432 00:16:10,520 --> 00:16:11,080 THERE WAS A LINE THEREFORE 433 00:16:11,080 --> 00:16:12,480 PANDEMIC PREPAREDNESS, BUT IT 434 00:16:12,480 --> 00:16:13,080 ALL DROPPED OUT BEFORE IT WAS 435 00:16:13,080 --> 00:16:13,720 ENACTED SO THIS BUDGET BECAME 436 00:16:13,720 --> 00:16:16,280 OFFICIAL IN JANUARY, SHORTLY 437 00:16:16,280 --> 00:16:19,720 BEFORE DOCTOR FAUCI STEP DOWN 438 00:16:19,720 --> 00:16:21,160 SO WE SAT DOWN WITH HIM AND 439 00:16:21,160 --> 00:16:21,760 AGREED THAT IT JUST IS NOT 440 00:16:21,760 --> 00:16:26,600 POSSIBLE FOR NIAID TO GO 441 00:16:26,600 --> 00:16:27,200 FORWARD WITHOUT SOME KIND OF 442 00:16:27,200 --> 00:16:28,400 PANDEMIC PREPAREDNESS PROGRAM. 443 00:16:28,400 --> 00:16:33,120 AND SO WE HAVE AGREED TO USE 444 00:16:33,120 --> 00:16:33,760 100 MILLION DOLLARS OF OUR OWN 445 00:16:33,760 --> 00:16:38,840 FUNDS IN ORDER TO INITIATE THE 446 00:16:38,840 --> 00:16:39,480 REVAMP NETWORK WHICH I BELIEVE 447 00:16:39,480 --> 00:16:40,800 WAS APPROVED IN COUNCIL AT HIS 448 00:16:40,800 --> 00:16:45,360 LAST SESSION WHICH IS A NETWORK 449 00:16:45,360 --> 00:16:45,920 OF RESEARCH OR WILL BE A 450 00:16:45,920 --> 00:16:46,840 NETWORK OF RESEARCH CENTERS TO 451 00:16:46,840 --> 00:16:49,080 DEVELOP VACCINES AND 452 00:16:49,080 --> 00:16:49,720 ANTIBIOTICS USING THE PROTOTYPE 453 00:16:49,720 --> 00:16:53,120 PATHOGEN APPROACH. THE 454 00:16:53,120 --> 00:16:53,680 APPLICATIONS ARE DUE JUST A 455 00:16:53,680 --> 00:16:58,120 COUPLE OF DAYS NOW. AND WE 456 00:16:58,120 --> 00:17:06,040 WILL COME BACK TO COUNCIL FOR 457 00:17:06,040 --> 00:17:06,600 REVIEW IN JANUARY SO WE ARE 458 00:17:06,600 --> 00:17:07,240 DOING PANDEMIC PREPAREDNESS BUT 459 00:17:07,240 --> 00:17:07,840 WE HAVE TO FUNDED FROM OUR OWN 460 00:17:07,840 --> 00:17:10,000 ORDINARY APPROPRIATIONS. 461 00:17:10,000 --> 00:17:10,520 NOW THE PRESIDENT RELEASES 462 00:17:10,520 --> 00:17:13,240 BUDGET ON MARCH 9. IT LOOKED 463 00:17:13,240 --> 00:17:16,360 LIKE THIS. I AM A MEMBER OF THE 464 00:17:16,360 --> 00:17:18,720 EXECUTIVE BRANCH AND SO IT IS 465 00:17:18,720 --> 00:17:19,200 MY JOB TO SUPPORT THE 466 00:17:19,200 --> 00:17:21,520 PRESIDENT'S BUDGET, OF COURSE I 467 00:17:21,520 --> 00:17:22,960 DO BUT I WILL REPORT TO YOU 468 00:17:22,960 --> 00:17:27,120 WHAT A PRIVATE CITIZEN NAMED 469 00:17:27,120 --> 00:17:30,960 TONY FOUCI DID. HE CALL ME WHEN 470 00:17:30,960 --> 00:17:31,520 THE PRESIDENT'S BUDGET WAS 471 00:17:31,520 --> 00:17:36,440 REASON HE SAID, WHAT THE HECK? 472 00:17:36,440 --> 00:17:37,080 ACTUALLY THAT IS NOT QUITE WHAT 473 00:17:37,080 --> 00:17:42,360 HE SAID BUT YOU GET THE IDEA. 474 00:17:42,360 --> 00:17:42,920 FRANKLY I THINK THAT WE PAY 475 00:17:42,920 --> 00:17:43,560 RELATIVELY LITTLE ATTENTION TO 476 00:17:43,560 --> 00:17:45,160 THE PRESIDENT'S BUDGET. YOU MAY 477 00:17:45,160 --> 00:17:45,720 RECALL THAT DURING THE CROP 478 00:17:45,720 --> 00:17:46,440 ADMINISTRATION WERE REGULAR 479 00:17:46,440 --> 00:17:51,000 EARLY SO 25% CUTS BEING 480 00:17:51,000 --> 00:17:51,600 RECOMMENDED BY THE PRESIDENT 481 00:17:51,600 --> 00:17:52,120 AND INSTEAD GAVE US AN 482 00:17:52,120 --> 00:17:56,640 INCREASE. THIS HOWEVER IS A 483 00:17:56,640 --> 00:17:57,200 DIFFERENT TIME AND I DON'T 484 00:17:57,200 --> 00:17:59,520 THINK EVEN BEFORE NEGOTIATIONS 485 00:17:59,520 --> 00:18:02,840 FOR THE DEBT CEILING, THAT WE 486 00:18:02,840 --> 00:18:03,440 WERE LIKELY TO SEE MUCH OF AN 487 00:18:03,440 --> 00:18:12,600 INCREASE IN FACT I THINK THAT 488 00:18:12,600 --> 00:18:13,240 THE PRESIDENT ALREADY SEEN THE 489 00:18:13,240 --> 00:18:13,840 WRITING ON THE WALL WITH THIS 490 00:18:13,840 --> 00:18:14,440 CONGRESS THAT WE WOULD NOT GET 491 00:18:14,440 --> 00:18:15,720 A VERY BIG INCREASE WITH THE 492 00:18:15,720 --> 00:18:16,360 NEGOTIATIONS TO RAISE THE DEBT 493 00:18:16,360 --> 00:18:19,040 CEILING. 494 00:18:19,040 --> 00:18:19,520 THIS IS A SLIDE THAT YOU 495 00:18:19,520 --> 00:18:20,280 PROBABLY HAVE SEEN MANY TIMES, 496 00:18:20,280 --> 00:18:25,840 THE RELATIVE SIZE OF THE NIH 497 00:18:25,840 --> 00:18:26,440 BUDGET WITH CANCER BEING THE 498 00:18:26,440 --> 00:18:27,000 LARGEST IN HOURS BEING THE 499 00:18:27,000 --> 00:18:30,120 SECOND LARGEST. BUT IF YOU 500 00:18:30,120 --> 00:18:35,360 HAVE WATCHED OVER THE YEARS, 501 00:18:35,360 --> 00:18:35,960 NATIONAL INSTITUTE OF AGING IS 502 00:18:35,960 --> 00:18:37,240 NOW THE THIRD LARGEST INSTITUTE 503 00:18:37,240 --> 00:18:41,720 AT NIH BECAUSE SOME OF US BABY 504 00:18:41,720 --> 00:18:42,280 BOOMERS ARE GETTING OLD AND 505 00:18:42,280 --> 00:18:46,640 WORRIED ABOUT AGING ILLNESSES. 506 00:18:46,640 --> 00:18:47,280 BUT THE BIGGEST CHANGE OVER THE 507 00:18:47,280 --> 00:18:47,920 COURSE OF THE TIME THAT I HAVE 508 00:18:47,920 --> 00:18:48,480 BEEN HERE IN THE OFFICE OF 509 00:18:48,480 --> 00:18:51,520 DIRECTOR. WHEN I GOT HERE TO 510 00:18:51,520 --> 00:18:54,680 GO SOMEWHERE BETWEEN FOGARTY 511 00:18:54,680 --> 00:18:55,280 AND THE NURSING INSTITUTE IN 512 00:18:55,280 --> 00:18:55,880 RELATIVE SIZE AND IS NOW A GOOD 513 00:18:55,880 --> 00:18:58,960 SIZE INSTITUTE OF ITS OWN. 514 00:18:58,960 --> 00:19:03,240 THIS IS OUR BUDGET. THE LAST 7 515 00:19:03,240 --> 00:19:03,880 TO 8 YEARS HAVE BEEN RELATIVELY 516 00:19:03,880 --> 00:19:08,560 GOOD FOR US. THIS IS THE 517 00:19:08,560 --> 00:19:11,160 PRESIDENT'S BUDGET HERE AT 518 00:19:11,160 --> 00:19:11,800 FLAT; BUT FLAT I DON'T THINK IS 519 00:19:11,800 --> 00:19:14,320 INDEED WHAT WE WILL SEE. 520 00:19:14,320 --> 00:19:14,920 NOW YOU HAVE SEEN THIS BEFORE 521 00:19:14,920 --> 00:19:18,120 MANY TIMES. THE IMPORTANT 522 00:19:18,120 --> 00:19:21,840 NUMBER HERE IS THE 12 523 00:19:21,840 --> 00:19:22,440 PERCENTILE, UNFORTUNATELY WE 524 00:19:22,440 --> 00:19:23,040 HAD TO STRUGGLE EVEN TO GET TO 525 00:19:23,040 --> 00:19:25,400 THE 12 PERCENTILE FOR OUR PAIN 526 00:19:25,400 --> 00:19:25,880 LINE THIS YEAR WHICH IS 527 00:19:25,880 --> 00:19:27,080 DISCOURAGING. 528 00:19:27,080 --> 00:19:35,680 NOW, I HAVE BEEN COMPLAINING 529 00:19:35,680 --> 00:19:36,960 IN THE BUDGET THESE PAST TENSE 530 00:19:36,960 --> 00:19:37,560 SLIDES BUT LET ME ADMIT THAT 531 00:19:37,560 --> 00:19:38,120 OVER THE COURSE OF THE PAST 532 00:19:38,120 --> 00:19:38,680 SEVERAL YEARS WE HAVE HAD 533 00:19:38,680 --> 00:19:45,240 ADDITIONAL FUNDING FOR THE 534 00:19:45,240 --> 00:19:45,840 COVID RESPONSE AND WE STARTED 535 00:19:45,840 --> 00:19:46,480 WITH $1.5 BILLION APPROPRIATION 536 00:19:46,480 --> 00:19:52,480 FROM CONGRESS TO US IN THIS 537 00:19:52,480 --> 00:19:53,040 SLIDE LISTED 140 MILLION IS 538 00:19:53,040 --> 00:19:53,640 FORECAST TO BE SPENT. WHAT WE 539 00:19:53,640 --> 00:20:00,120 HAVE IS COMMITMENTS FOR OUT 540 00:20:00,120 --> 00:20:00,680 YEAR FUNDING FOR NOT GET 541 00:20:00,680 --> 00:20:01,280 OBLIGATIONS. I WILL SHOW YOU 542 00:20:01,280 --> 00:20:03,440 WHERE THAT ONE JUST A MOMENT. 543 00:20:03,440 --> 00:20:05,520 IN ADDITION TO THE 1.5 BILLION 544 00:20:05,520 --> 00:20:10,040 WE RECEIVE THESE AMOUNTS, 3.3, 545 00:20:10,040 --> 00:20:10,640 CLOSE TO $5 BILLION ALL TOTAL 546 00:20:10,640 --> 00:20:11,240 OVER THE PAST THREE YEARS DUE 547 00:20:11,240 --> 00:20:13,360 TO BOTH THERAPEUTIC RESEARCH 548 00:20:13,360 --> 00:20:17,760 AND VACCINE RESEARCH. 549 00:20:17,760 --> 00:20:20,800 NOW, THE DEBT CEILING 550 00:20:20,800 --> 00:20:21,440 LEGISLATION. FROM OUR POINT OF 551 00:20:21,440 --> 00:20:22,040 VIEW THERE WERE TWO CRITICAL 552 00:20:22,040 --> 00:20:27,400 PARTS OF IT. ONE IS A LIMIT ON 553 00:20:27,400 --> 00:20:27,840 FEDERAL NONDEFENSE 554 00:20:27,840 --> 00:20:29,600 DISCRETIONARY SPENDING BOTH IN 555 00:20:29,600 --> 00:20:30,160 FISCAL YEAR 24 AND 25; SO I 556 00:20:30,160 --> 00:20:30,800 THINK THE HANDWRITING IS PRETTY 557 00:20:30,800 --> 00:20:34,640 CLEAR. WE ARE GOING TO BE FLAT 558 00:20:34,640 --> 00:20:39,960 OVER THE NEXT YEAR TO TWO. 559 00:20:39,960 --> 00:20:40,560 IN ADDITION, THIS LEGISLATION 560 00:20:40,560 --> 00:20:43,800 PRESENTS ANY UNOBLIGATED COVID 561 00:20:43,800 --> 00:20:47,320 SUPPLEMENT FUNDING ACROSS THE 562 00:20:47,320 --> 00:20:47,960 GOVERNMENT, WHICH WAS ESTIMATED 563 00:20:47,960 --> 00:20:49,080 TO BE IN THE RANGE OF $30 564 00:20:49,080 --> 00:20:55,640 BILLION. WE GOT WORD THAT THIS 565 00:20:55,640 --> 00:21:02,640 KIND OF RESCISSION WAS A REAL 566 00:21:02,640 --> 00:21:03,240 POSSIBILITY ABOUT THREE WEEKS 567 00:21:03,240 --> 00:21:03,800 BEFORE THE LEGISLATION WAS 568 00:21:03,800 --> 00:21:04,880 SIGNED BY THE PRESIDENT SO WE 569 00:21:04,880 --> 00:21:05,400 HAVE HAD MEMBERS OF OUR 570 00:21:05,400 --> 00:21:06,040 DIVISION OF EXTRAMURAL ACTIVITY 571 00:21:06,040 --> 00:21:07,960 IS WORKING LITERALLY DAY AND 572 00:21:07,960 --> 00:21:10,440 NIGHT TO MAKE SURE THAT ALL OF 573 00:21:10,440 --> 00:21:11,800 THE MONEY THAT WAS GIVEN TO US 574 00:21:11,800 --> 00:21:17,720 ACTUALLY IS OUT THE DOOR AND 575 00:21:17,720 --> 00:21:18,360 OBLIGATED, INCLUDING 300 ALIEN 576 00:21:18,360 --> 00:21:18,960 THAT WE RECENTLY RECEIVED, OR 577 00:21:18,960 --> 00:21:22,440 RECEIVED LATE LAST WEEK FOUR 578 00:21:22,440 --> 00:21:27,080 THE NEXTGEN VACCINE STUDIES. 579 00:21:27,080 --> 00:21:27,680 WE HAVE ESSENTIALLY SAVED 400 580 00:21:27,680 --> 00:21:32,960 PLUS MILLION DOLLARS BY THE 581 00:21:32,960 --> 00:21:33,600 HARD WORK OF THE PEOPLE IN THE 582 00:21:33,600 --> 00:21:37,640 DIVISION OF EXTRAMURAL; I THINK 583 00:21:37,640 --> 00:21:38,240 WE ENDED UP WITH $1 MILLION 584 00:21:38,240 --> 00:21:38,840 THAT WE COULD NOT GET OUT THE 585 00:21:38,840 --> 00:21:39,480 DOOR AT THE LAST MINUTE THAT IT 586 00:21:39,480 --> 00:21:42,520 WAS A PRETTY HEROIC EFFORT THAT 587 00:21:42,520 --> 00:21:44,400 WENT INTO THIS. THOSE PEOPLE OF 588 00:21:44,400 --> 00:21:45,520 COURSE ARE NEVER SEEN OUTSIDE 589 00:21:45,520 --> 00:21:49,080 OF THEIR OFFICES. WE DON'T 590 00:21:49,080 --> 00:21:49,680 RECOGNIZE AND WHAT WE REALLY 591 00:21:49,680 --> 00:21:54,480 NEED TO BE AWARE OF THE AMOUNT 592 00:21:54,480 --> 00:21:55,000 OF EFFORT THAT WENT INTO 593 00:21:55,000 --> 00:21:55,680 GETTING THIS MONEY OBLIGATED IN 594 00:21:55,680 --> 00:21:56,280 TIME. 595 00:21:56,280 --> 00:21:59,400 LEGISLATIVE UPDATE. I HAVE 596 00:21:59,400 --> 00:22:00,000 BEEN FORTUNATE TO ONLY HAVE TO 597 00:22:00,000 --> 00:22:00,560 GO TO CONGRESS WANTS, 598 00:22:00,560 --> 00:22:06,080 ACCOMPANIED DOCTOR TADEBACK FOR 599 00:22:06,080 --> 00:22:06,720 A BRIEFING WITH SENATOR BERNIE 600 00:22:06,720 --> 00:22:16,880 SANDERS. HIS CASE TO US WAS 601 00:22:16,880 --> 00:22:17,440 HEY, NIH, YOU SPENT OVER $1 602 00:22:17,440 --> 00:22:23,680 BILLION DOLLARS HELPING TO MAKE 603 00:22:23,680 --> 00:22:24,280 MODERNA APPROVED ANOTHER HAVE 604 00:22:24,280 --> 00:22:26,440 MADE MILLIONS OF DOLLARS. DON'T 605 00:22:26,440 --> 00:22:29,200 YOU HAVE LEVERAGE OVER THERE ON 606 00:22:29,200 --> 00:22:29,840 PRICING? OUR ANSWER WAS NO AND 607 00:22:29,840 --> 00:22:30,720 HE DID NOT LIKE THE ANSWER. 608 00:22:30,720 --> 00:22:32,120 THERE WAS A TIME IN THE PAST 609 00:22:32,120 --> 00:22:37,000 WHEN NIH TRIED TO LICENSE ITS 610 00:22:37,000 --> 00:22:37,600 INVENTION WITH A REASONABLE 611 00:22:37,600 --> 00:22:39,600 PRICING CLAUSE IN IT, AND 612 00:22:39,600 --> 00:22:40,840 COMPANY SIMPLY WALKED AWAY FROM 613 00:22:40,840 --> 00:22:42,320 THAT POSSIBILITY. SO NOTHING 614 00:22:42,320 --> 00:22:46,560 HAPPENED. IT WAS UNDER HAROLD 615 00:22:46,560 --> 00:22:47,160 -- WE STUDIED THIS ISSUE AND 616 00:22:47,160 --> 00:22:50,920 CONCLUDED THAT WE CANNOT PUT 617 00:22:50,920 --> 00:22:51,560 DRUG PRICING INTO OUR LICENSING 618 00:22:51,560 --> 00:22:54,480 AGREEMENTS. SO WE DON'T HAVE 619 00:22:54,480 --> 00:22:59,440 ANY LEVERAGE OVER MODERNA. 620 00:22:59,440 --> 00:23:09,920 SHOUT TO -- -- WHO ACCOMPANIED 621 00:23:12,680 --> 00:23:13,240 DOCTOR TADEBACK OUR GURU FOR 622 00:23:13,240 --> 00:23:16,240 SEQUENCE ANALYSIS. I ALSO 623 00:23:16,240 --> 00:23:17,640 APPRECIATE ALL THE EFFORT THAT 624 00:23:17,640 --> 00:23:18,920 THIS INDIVIDUAL PUT IN OVER THE 625 00:23:18,920 --> 00:23:24,960 COURSE OF THE PAST 3-4 MONTHS. 626 00:23:24,960 --> 00:23:25,520 NO ONE OTHER CONGRESSIONAL 627 00:23:25,520 --> 00:23:30,440 ACTION ON WORLD MALARIA DAY, 628 00:23:30,440 --> 00:23:32,960 RECOGNITION OF MALARIA RESEARCH 629 00:23:32,960 --> 00:23:33,800 AT NIH THIS TIME IT IS BOB 630 00:23:33,800 --> 00:23:36,560 SEDER (PHONETIC) WHO WAS 631 00:23:36,560 --> 00:23:37,160 RECEIVING THE RECOGNITION ON 632 00:23:37,160 --> 00:23:40,240 BEHALF OF THE NIH BUT ACTUALLY 633 00:23:40,240 --> 00:23:40,840 THE IMPORTANT WORK THAT THEY 634 00:23:40,840 --> 00:23:42,800 ARE REFERRING TO WAS A 635 00:23:42,800 --> 00:23:44,160 COLLABORATION BETWEEN PETER 636 00:23:44,160 --> 00:23:45,200 COMPTON WHOM I MENTIONED BEFORE 637 00:23:45,200 --> 00:23:55,200 AND BOB SEDER, AND IT WAS THE 638 00:23:55,200 --> 00:23:58,880 WORK WITH MONOCLONAL ANTIBODY 639 00:23:58,880 --> 00:23:59,480 AGAINST MALARIA. THIS WAS ONE 640 00:23:59,480 --> 00:24:02,680 OF THE RESULTS, 88% PREVENTION 641 00:24:02,680 --> 00:24:06,560 STUNNING RESULT, IN THIS AND 642 00:24:06,560 --> 00:24:09,560 SUBSEQUENT GENERATION OF 643 00:24:09,560 --> 00:24:10,160 MONOCLONAL ANTIBODIES ARE IN 644 00:24:10,160 --> 00:24:10,800 DEVELOPMENT AS WE WORK TOWARDS 645 00:24:10,800 --> 00:24:15,960 POTENTIALLY BRINGING THESE 646 00:24:15,960 --> 00:24:26,160 LICENSURES. 647 00:24:29,840 --> 00:24:30,440 I NOW WILL DO A QUICK RESEARCH 648 00:24:30,440 --> 00:24:31,080 UPDATE IN A NUMBER OF DIFFERENT 649 00:24:31,080 --> 00:24:31,680 AREAS. MOST OF THEM WILL BE 650 00:24:31,680 --> 00:24:32,320 FAMILIAR TO YOU SO WE WILL MOVE 651 00:24:32,320 --> 00:24:35,840 QUICKLY. YOU ARE AWARE THAT THE 652 00:24:35,840 --> 00:24:36,440 NCDC HAS DECLARED THE PUBLIC 653 00:24:36,440 --> 00:24:37,440 HEALTH EMERGENCY OVER THAT DOES 654 00:24:37,440 --> 00:24:47,200 NOT MEAN COVID IS OVER BECAUSE 655 00:24:47,200 --> 00:24:47,800 WE'RE STILL RUNNING AROUND 200 656 00:24:47,800 --> 00:24:49,360 DEATHS PER DAY, ABOUT 10,000 657 00:24:49,360 --> 00:24:49,920 PEOPLE IN THE YEAR WHICH IS 658 00:24:49,920 --> 00:24:51,960 STILL TOO HIGH. MANY OF THE 659 00:24:51,960 --> 00:24:52,560 PEOPLE WHO ARE DYING AT THIS 660 00:24:52,560 --> 00:24:54,840 POINT ARE PEOPLE WHO ARE 661 00:24:54,840 --> 00:24:55,480 IMMUNOCOMPROMISED OR OLD BUT IT 662 00:24:55,480 --> 00:24:56,040 IS STILL TRUE THAT WE CAN 663 00:24:56,040 --> 00:25:00,480 PROTECT PEOPLE BETTER, WITH 664 00:25:00,480 --> 00:25:05,920 BETTER USE OF PAXLOVID AND 665 00:25:05,920 --> 00:25:10,600 PEOPLE USING THE BIVALENT 666 00:25:10,600 --> 00:25:11,240 BOOSTERS. ONLY ABOUT 30 TO 40% 667 00:25:11,240 --> 00:25:11,880 PEOPLE ARE AVAILING THEMSELVES 668 00:25:11,880 --> 00:25:12,480 OF THAT OPPORTUNITY. 669 00:25:12,480 --> 00:25:19,200 DOCTOR FOUCI HAS GIVEN TALKS 670 00:25:19,200 --> 00:25:19,800 TO US AND I'VE USED A STOCK ON 671 00:25:19,800 --> 00:25:20,400 ONE OR TWO OCCASIONS ABOUT 672 00:25:20,400 --> 00:25:22,520 LESSONS FROM CVOID-19. I WILL 673 00:25:22,520 --> 00:25:26,960 MENTION ONE HERE. IT WAS VERY 674 00:25:26,960 --> 00:25:27,440 IMPORTANT FOR US TO USE 675 00:25:27,440 --> 00:25:30,240 EXISTING CLINICAL TRIAL 676 00:25:30,240 --> 00:25:30,880 INFRASTRUCTURE IN ORDER TO MOVE 677 00:25:30,880 --> 00:25:31,480 FORWARD ON THE PANDEMIC WITH 678 00:25:31,480 --> 00:25:32,160 THE SPEED THAT WE DID. 679 00:25:32,160 --> 00:25:39,400 SO WE CREATED USING THE HTBN, 680 00:25:39,400 --> 00:25:45,960 THE HTPN, THE HTPG SITES, TO 681 00:25:45,960 --> 00:25:48,920 CREATE THE CVOID-19 PREVENTION 682 00:25:48,920 --> 00:25:52,160 NETWORK CAN THIS NETWORK 683 00:25:52,160 --> 00:25:56,320 CREATED HARMONIZE CLINICAL 684 00:25:56,320 --> 00:25:56,960 TRIALS WITH COMMON END POINTS, 685 00:25:56,960 --> 00:26:00,240 COMMON ASSAYS, A SINGLE IRB, 686 00:26:00,240 --> 00:26:00,840 AND WE WERE ABLE TO RUN OVER 687 00:26:00,840 --> 00:26:06,720 THE COURSE OF THE FIRST YEAR, 688 00:26:06,720 --> 00:26:07,360 FIVE PHASE 3 TRIALS IN A TOTAL 689 00:26:07,360 --> 00:26:10,320 OF HUNDRED 36,000 DEPENDS, 690 00:26:10,320 --> 00:26:10,880 LEADING TO LICENSURE OF A 691 00:26:10,880 --> 00:26:12,000 NUMBER OF THESE VACCINES. 692 00:26:12,000 --> 00:26:22,320 THIS IS THE CVOID-19 693 00:26:24,080 --> 00:26:24,640 PREVENTION NETWORK AND YOU CAN 694 00:26:24,640 --> 00:26:25,240 SEE THE BREADTH OF THE SITE 695 00:26:25,240 --> 00:26:25,920 INVOLVED IN THIS RESPONSE. 696 00:26:25,920 --> 00:26:29,040 I MENTIONED ALREADY PROJECT 697 00:26:29,040 --> 00:26:32,240 NEXTGEN, SOMETHING DEVISED BY 698 00:26:32,240 --> 00:26:32,880 -- BUT WE STILL NEED TO DO AND 699 00:26:32,880 --> 00:26:37,520 BY WAY OF A COVID RESPONSE 700 00:26:37,520 --> 00:26:38,120 CREATING LONG-LASTING MUCOSAL 701 00:26:38,120 --> 00:26:39,280 VACCINES AND OTHER NEW 702 00:26:39,280 --> 00:26:40,600 TECHNOLOGIES IN THE NIAID ROLE 703 00:26:40,600 --> 00:26:47,520 IS TO INITIATE A CLINICAL TRIAL 704 00:26:47,520 --> 00:26:49,120 TO EVALUATE MUCOSAL AND BROADLY 705 00:26:49,120 --> 00:26:50,440 PROTECTIVE VACCINES. THAT WAS 706 00:26:50,440 --> 00:26:53,960 THE LAST $300 MILLION OF COVID 707 00:26:53,960 --> 00:26:54,480 FUNDING THAT CAME TO OUR 708 00:26:54,480 --> 00:26:59,040 AGENCY. 709 00:26:59,040 --> 00:26:59,640 SPEAKING OF MUCOSAL VACCINES, 710 00:26:59,640 --> 00:27:04,200 JANE ASHLEY (PHONETIC) FROM -- 711 00:27:04,200 --> 00:27:08,440 DEVELOPED THE BRAINCHILD OF 712 00:27:08,440 --> 00:27:10,440 HERS TO HAVE A WORKSHOP ON 713 00:27:10,440 --> 00:27:11,040 MUCOSAL VACCINES, WHICH TOOK 714 00:27:11,040 --> 00:27:13,080 PLACE LAST YEAR. THIS IS THE 715 00:27:13,080 --> 00:27:18,680 REPORT OF THAT WORKSHOP, THAT 716 00:27:18,680 --> 00:27:19,200 CAME OUT IN APRIL OF THIS 717 00:27:19,200 --> 00:27:21,040 SPRING. 718 00:27:21,040 --> 00:27:21,640 WHILE THIS WAS HER IDEA, MANY 719 00:27:21,640 --> 00:27:31,320 OTHER GROUPS, BARTA, SEPI, THE 720 00:27:31,320 --> 00:27:31,840 WELLCOME TRUST, BILL AND 721 00:27:31,840 --> 00:27:33,120 MELINDA GATES FOUNDATION ALL 722 00:27:33,120 --> 00:27:33,720 WANTED TO PARTICIPATE IN WHY 723 00:27:33,720 --> 00:27:36,600 NOT BECAUSE IT WAS GREAT. IT 724 00:27:36,600 --> 00:27:37,200 WAS A TERRIFIC WORKSHOP THAT 725 00:27:37,200 --> 00:27:37,800 FUNDAMENTALLY POINTED OUT SOME 726 00:27:37,800 --> 00:27:40,200 OF THE DIFFICULT THESE THAT LIE 727 00:27:40,200 --> 00:27:40,760 AHEAD FOR DEVELOPING TRULY 728 00:27:40,760 --> 00:27:44,960 PROTECTIVE MUCOSAL VACCINES. 729 00:27:44,960 --> 00:27:46,680 ANOTHER ONGOING ACTIVITY IN 730 00:27:46,680 --> 00:27:47,280 THE AREA OF COVERT RESEARCH IS 731 00:27:47,280 --> 00:27:52,280 THE SO-CALLED STRIVE PROTOCOL 732 00:27:52,280 --> 00:27:53,760 WHICH IS EVALUATING FUTURE 733 00:27:53,760 --> 00:27:54,520 ANTIVIRALS, FOR THOSE 734 00:27:54,520 --> 00:27:55,320 HOSPITALIZED ADULTS WITH 735 00:27:55,320 --> 00:27:59,400 CVOID-19. THE MOST IMPORTANT 736 00:27:59,400 --> 00:28:00,040 TRIAL AT THIS POINT INVOLVES A 737 00:28:00,040 --> 00:28:04,160 PRODUCT FROM JAPAN KNOWN AS 738 00:28:04,160 --> 00:28:10,280 SHINOGI (PHONETIC) ANTIVIRAL 739 00:28:10,280 --> 00:28:10,920 AND THIS PLAN IS TO ENROLL 1500 740 00:28:10,920 --> 00:28:14,160 PEOPLE TO ASSESS THE CLINICAL 741 00:28:14,160 --> 00:28:17,240 EFFICACY OF THIS NEW ANTIVIRAL. 742 00:28:17,240 --> 00:28:21,320 IT IS A PROTEASE INHIBITOR DOES 743 00:28:21,320 --> 00:28:21,920 NOT HAVE THE DRUG INTERACTION 744 00:28:21,920 --> 00:28:26,000 EFFECT THAT PAX LOVID HAD. IT 745 00:28:26,000 --> 00:28:26,640 LOOKS LIKE IT WILL BE EASIER TO 746 00:28:26,640 --> 00:28:29,480 USE. 747 00:28:29,480 --> 00:28:35,560 VIRUS UPDATE. IT ALL IN THE 748 00:28:35,560 --> 00:28:36,160 DEMOCRATIC REPUBLIC OF CONGO, 749 00:28:36,160 --> 00:28:41,400 TANZANIA WITH -- INCIDENTALLY 750 00:28:41,400 --> 00:28:44,160 THERE IS ALSO SUDAN IN 2022 AND 751 00:28:44,160 --> 00:28:51,840 UGANDA, EQUATORIAL GUINEA WITH 752 00:28:51,840 --> 00:28:52,480 (INDISCERNIBLE), THESE RELATED 753 00:28:52,480 --> 00:28:53,120 VIRUSES HAVE CONTINUED TO BE A 754 00:28:53,120 --> 00:29:03,640 PROBLEM IN AFRICA. WORK FROM 755 00:29:04,000 --> 00:29:04,520 THE INTRAMURAL PROGRAM HAS 756 00:29:04,520 --> 00:29:06,400 SHOWN IN NONHUMAN PREMISE THAT 757 00:29:06,400 --> 00:29:08,120 YOU GET RAPID PROTECTION 758 00:29:08,120 --> 00:29:12,560 AGAINST MARBER (PHONETIC) 759 00:29:12,560 --> 00:29:15,760 VIRUS, AND FROM THE VRC, THAT 760 00:29:15,760 --> 00:29:19,280 WAS DIR, THIS IS VRC, CHIMP 761 00:29:19,280 --> 00:29:25,000 WITH THE MARBER VACCINE IN 762 00:29:25,000 --> 00:29:25,600 PHASE I TRIALS WITH EXCELLENT 763 00:29:25,600 --> 00:29:28,720 ANTIBODY RESPONSES. AND HINES 764 00:29:28,720 --> 00:29:29,280 FELDMAN IN THE INTRAMURAL 765 00:29:29,280 --> 00:29:35,520 PROGRAM HAS -- AND DISSIDENT 766 00:29:35,520 --> 00:29:36,080 VACCINE WHICH IS LOOKING 767 00:29:36,080 --> 00:29:37,120 PROMISING IN NONHUMAN PREMISE 768 00:29:37,120 --> 00:29:39,600 AS WELL. 769 00:29:39,600 --> 00:29:49,200 MPOX UPDATE, AS YOU KNOW, 770 00:29:49,200 --> 00:29:49,800 MPOX IS ENDEMIC AND PORTIONS OF 771 00:29:49,800 --> 00:29:50,400 AFRICA BUT OVER THE PAST YEAR 772 00:29:50,400 --> 00:29:54,440 THERE HAS BEEN A MAJOR OUTBREAK 773 00:29:54,440 --> 00:29:57,440 AROUND THE WORLD, AROUND 87,000 774 00:29:57,440 --> 00:30:00,680 CONFIRMED CASES OF MPOX. 775 00:30:00,680 --> 00:30:01,680 IN THIS COUNTRY THE INCIDENTS 776 00:30:01,680 --> 00:30:02,880 LOOKS LIKE THIS SINCE I TOOK 777 00:30:02,880 --> 00:30:03,520 OVER AS THE ACTING DIRECTOR IN 778 00:30:03,520 --> 00:30:06,320 JANUARY. IT HAS BEEN PRETTY 779 00:30:06,320 --> 00:30:11,600 SMALL PROBLEM ON OUR WATCH. WE 780 00:30:11,600 --> 00:30:12,960 WERE UNDER PRESSURE TO ADD A 781 00:30:12,960 --> 00:30:13,520 RESEARCH COMPONENT, TO THE 782 00:30:13,520 --> 00:30:16,840 EFFORT TO RESPOND TO MPOX. WE 783 00:30:16,840 --> 00:30:21,480 HAVE A VACCINE FROM GENIOS 784 00:30:21,480 --> 00:30:23,840 (PHONETIC), EFFECTIVE AGAINST 785 00:30:23,840 --> 00:30:30,080 MPOX AND TPOX THAT WAS ALSO 786 00:30:30,080 --> 00:30:30,680 EFFECTIVE NOT A WHOLE LOT FOR 787 00:30:30,680 --> 00:30:33,200 US TO DO. WE INITIATED A TRIAL 788 00:30:33,200 --> 00:30:33,760 FOR YOUNGER INDIVIDUALS TO 789 00:30:33,760 --> 00:30:37,680 RECEIVE THE GENIOS VACCINE 790 00:30:37,680 --> 00:30:38,280 WHICH UP UNTIL THAT POINT WAS 791 00:30:38,280 --> 00:30:39,280 ONLY APPROVED FOR ADULT. 792 00:30:39,280 --> 00:30:46,440 HIV AIDS, TWO MAJOR ITEMS. 793 00:30:46,440 --> 00:30:53,400 FIRST VERY RECENTLY THE FIRST 794 00:30:53,400 --> 00:30:54,000 IN HUMAN GERMLINE TARGETED HIV 795 00:30:54,000 --> 00:30:56,400 NANO PARTICLE HAD INTERESTING T 796 00:30:56,400 --> 00:30:57,640 CELL INDUCING PROPERTIES THAT 797 00:30:57,640 --> 00:30:58,240 APPARENTLY ARE GOING TO HELP 798 00:30:58,240 --> 00:31:02,400 WITH THE B CELL RESPONSE AS 799 00:31:02,400 --> 00:31:05,520 WELL SO KEEP AN EYE ON THIS ONE. 800 00:31:05,520 --> 00:31:07,640 THEN THERE IS THE REPRIEVE 801 00:31:07,640 --> 00:31:09,840 STUDY WHICH ENDED UP ENROLLING 802 00:31:09,840 --> 00:31:14,240 CLOSE TO 8000 VOLUNTEERS. THESE 803 00:31:14,240 --> 00:31:14,840 ARE PEOPLE WHO DID NOT HAVE A 804 00:31:14,840 --> 00:31:15,400 HIGH RISK OF CARDIOVASCULAR 805 00:31:15,400 --> 00:31:19,440 DISEASE, WHO WERE PUT ONA 806 00:31:19,440 --> 00:31:25,440 STATIN THE RESULT IS THAT 35% 807 00:31:25,440 --> 00:31:27,600 LOWER RISK OF MAJOR ADVERSE 808 00:31:27,600 --> 00:31:28,160 CARDIOVASCULAR EVENTS IN 809 00:31:28,160 --> 00:31:30,440 HIV-POSITIVE PEOPLE. THE STRAW 810 00:31:30,440 --> 00:31:34,920 CONTINUE DURING THE COVID 811 00:31:34,920 --> 00:31:35,560 OBJECT WHICH IS QUITE AMAZING. 812 00:31:35,560 --> 00:31:36,640 THEY WERE ABLE TO KEEP THE 813 00:31:36,640 --> 00:31:37,240 VOLUNTEERS ENROLLED IN THIS 814 00:31:37,240 --> 00:31:38,880 TRIAL. 815 00:31:38,880 --> 00:31:42,000 OTHER UPDATES VERY BRIEFLY. 816 00:31:42,000 --> 00:31:45,120 FDA HAS APPROVED THE FIRST RSV 817 00:31:45,120 --> 00:31:48,680 VACCINES FOR PEOPLE OVER 60. 818 00:31:48,680 --> 00:31:49,320 AS YOU KNOW ALL THE PEOPLE ARE 819 00:31:49,320 --> 00:31:52,560 AT RISK OF HOSPITALIZATION AND 820 00:31:52,560 --> 00:31:56,160 DEATH FROM RSV. YOU PROBABLY 821 00:31:56,160 --> 00:31:59,800 ALSO KNOW THAT SINCE THE 1960S 822 00:31:59,800 --> 00:32:00,360 IT HAS BEEN A STRUGGLE TO 823 00:32:00,360 --> 00:32:02,440 DEVELOP AN RSV VACCINE. INDEED 824 00:32:02,440 --> 00:32:03,200 EARLY ATTEMPTS SHOWED 825 00:32:03,200 --> 00:32:06,520 ENHANCEMENTS; NOW WE HAVE GSK 826 00:32:06,520 --> 00:32:09,040 WITH APPROVAL IN JUST LAST WEEK 827 00:32:09,040 --> 00:32:10,760 PFIZER HAS APPROVAL FOR OLDER 828 00:32:10,760 --> 00:32:14,960 ADULTS WITH THIS VACCINE. 829 00:32:14,960 --> 00:32:16,840 THE ADVISORY COMMITTEE IS ALSO 830 00:32:16,840 --> 00:32:20,800 RECOMMENDED THAT THE PFIZER 831 00:32:20,800 --> 00:32:22,360 VACCINE SHOULD BE AVAILABLE FOR 832 00:32:22,360 --> 00:32:27,080 INFANTS. ACTUALLY THIS IS 833 00:32:27,080 --> 00:32:30,440 VACCINATION OF PREGNANT WOMEN 834 00:32:30,440 --> 00:32:31,000 ROUGHLY HALFWAY THROUGH THE 835 00:32:31,000 --> 00:32:31,560 PREGNANCY TO PROTECT THEIR 836 00:32:31,560 --> 00:32:37,520 INFANTS AFTER BIRTH. THERE WERE 837 00:32:37,520 --> 00:32:42,480 FOUR PEOPLE ON THE ADVISORY 838 00:32:42,480 --> 00:32:45,840 COMMITTEE WHO WHILE ADMITTING 839 00:32:45,840 --> 00:32:47,720 THAT THE DATA SHOWED GREAT 840 00:32:47,720 --> 00:32:48,320 EFFICACY, THEY WERE CONCERNED 841 00:32:48,320 --> 00:32:49,160 ABOUT THE POSSIBILITY OF 842 00:32:49,160 --> 00:32:56,160 PREMATURE DELIVERY. THE 843 00:32:56,160 --> 00:32:56,720 INCIDENTS WAS 5.6% IN THE 844 00:32:56,720 --> 00:33:02,800 TREATMENT GROUP VERSUS 4.7% IN 845 00:33:02,800 --> 00:33:03,400 THE CONTROL ARM WHICH WAS NOT 846 00:33:03,400 --> 00:33:05,960 STATISTICALLY SIGNIFICANT. 847 00:33:05,960 --> 00:33:09,320 THEY DID BELIEVE THERE WAS A 848 00:33:09,320 --> 00:33:16,200 HIGHER INCIDENCE OF PRETERM 849 00:33:16,200 --> 00:33:16,840 DELIVERY. I DON'T KNOW WHAT THE 850 00:33:16,840 --> 00:33:17,440 FDA WILL DECIDE TO DO WHEN IS 851 00:33:17,440 --> 00:33:18,920 IT DOWN TO MAKE A DECISION ON 852 00:33:18,920 --> 00:33:20,560 THIS ONE. 853 00:33:20,560 --> 00:33:21,120 NOW I WANT TO SPEND A MOMENT 854 00:33:21,120 --> 00:33:28,920 ON RSV VACCINES, BECAUSE IT IS 855 00:33:28,920 --> 00:33:29,520 REALLY PART OF A HISTORY THAT 856 00:33:29,520 --> 00:33:32,320 IS QUITE SIGNIFICANT. BARNEY 857 00:33:32,320 --> 00:33:34,600 GRAHAM ALL OF HIS CAREER HAS 858 00:33:34,600 --> 00:33:44,720 WANTED TO MAKE AN RSV VACCINE, 859 00:33:44,720 --> 00:33:45,320 AND TRIED VERY HARD TO FIGURE 860 00:33:45,320 --> 00:33:48,520 OUT WHAT WAS WRONG WITH THE 861 00:33:48,520 --> 00:33:49,120 VACCINES BEFORE AND WHAT WE 862 00:33:49,120 --> 00:33:49,760 COULD DO TO MAKE A BIG THINGS 863 00:33:49,760 --> 00:33:50,320 NOT HE TEAMED UP WITH PETER 864 00:33:50,320 --> 00:33:52,640 QUAN (PHONETIC) AND JASON 865 00:33:52,640 --> 00:34:03,200 MCCLENDON (PHONETIC). PETER HAD 866 00:34:05,000 --> 00:34:05,560 BEEN WORKING ON THE HIV SERVICE 867 00:34:05,560 --> 00:34:06,440 PROTEIN AND THAT EXPERIENCED 868 00:34:06,440 --> 00:34:07,080 LED THE THREE OF THEM TO FIGURE 869 00:34:07,080 --> 00:34:07,560 OUT THAT THE PROBLEM IN 870 00:34:07,560 --> 00:34:13,160 PRODUCING AN-- FOR THE RSV WAS 871 00:34:13,160 --> 00:34:13,680 THE SPIKE PROTEIN OF THE 872 00:34:13,680 --> 00:34:14,200 CORONAVIRUS WHICH IS AN 873 00:34:14,200 --> 00:34:20,400 UNSTABLE MOLECULE, WHEN YOU 874 00:34:20,400 --> 00:34:21,000 TAKE IT OFF THE VIRAL SURFACE 875 00:34:21,000 --> 00:34:22,760 AND USE IT AS AN IMMUNOGENIC, 876 00:34:22,760 --> 00:34:23,840 IT FLIPS OPEN AND IT RUINS THE 877 00:34:23,840 --> 00:34:31,920 EPITOPES YOU MOST WANT TO STAY 878 00:34:31,920 --> 00:34:32,480 STIMULATE. HE FOUND THAT BY 879 00:34:32,480 --> 00:34:33,120 STABILIZING THIS PROTEIN IT WAS 880 00:34:33,120 --> 00:34:42,760 A MUCH BETTER IMMUNOGEN AND 881 00:34:42,760 --> 00:34:43,320 THAT IS THE BASIS OF THE 882 00:34:43,320 --> 00:34:48,600 VACCINES APPROVED. 883 00:34:48,600 --> 00:34:49,080 IN 2013 WHEN BARNEY HAD 884 00:34:49,080 --> 00:34:52,360 SETTLED ON THE MANNER OF 885 00:34:52,360 --> 00:34:52,920 STABILIZING THE PRE-FUSION 886 00:34:52,920 --> 00:34:53,520 PROTEIN HE DECIDED WHAT ELSE 887 00:34:53,520 --> 00:34:54,560 WOULD HE DO? HE FIGURED THAT 888 00:34:54,560 --> 00:34:57,600 HIS WE HAD SARS IN 2002 AND 889 00:34:57,600 --> 00:35:02,200 MERS IN 2012, HE REALLY DID 890 00:35:02,200 --> 00:35:04,240 BELIEVE THAT THEY WOULD BE A 891 00:35:04,240 --> 00:35:07,560 NEW CORONAVIRUS ARE BREAKING 892 00:35:07,560 --> 00:35:08,160 THE FUTURE SO HE SAT DOWN TO 893 00:35:08,160 --> 00:35:16,280 MAKE A MERS VACCINE AND WORKING 894 00:35:16,280 --> 00:35:16,920 WITH THE SAME PEOPLE PARTICULAR 895 00:35:16,920 --> 00:35:18,360 JASON MCCLENDON THEY DISCOVERED 896 00:35:18,360 --> 00:35:19,360 THAT JUST TWO PROLINE NOTATIONS 897 00:35:19,360 --> 00:35:26,640 IN THE S PROTEIN OF THE 898 00:35:26,640 --> 00:35:27,280 CORONAVIRUS WOULD STABILIZE THE 899 00:35:27,280 --> 00:35:37,360 PERFUSION MODULE CALLED THE S 900 00:35:37,360 --> 00:35:39,760 2P MUTATION AND WHEN THE 901 00:35:39,760 --> 00:35:45,480 SARS-COV-2 WAS PUBLISHED 902 00:35:45,480 --> 00:35:45,920 ONLINE, JANUARY 2020, 903 00:35:45,920 --> 00:35:50,200 SCIENTISTS FROM MODERNA AND 904 00:35:50,200 --> 00:36:00,560 FROM NIH TOGETHER LOOK AT THE 905 00:36:00,560 --> 00:36:01,080 SECONDS THE NEXT DAY AND 906 00:36:01,080 --> 00:36:01,640 CONCLUDED THAT THE SAME TWO 907 00:36:01,640 --> 00:36:02,200 MUTATIONS WERE LIKELY TO 908 00:36:02,200 --> 00:36:02,720 STABILIZE THE SARS-COV-2 909 00:36:02,720 --> 00:36:07,920 PRE-FUSION PROTEIN SO MODERNA 910 00:36:07,920 --> 00:36:08,480 SET OUT FIVE DAYS AFTER THE 911 00:36:08,480 --> 00:36:09,080 SEQUENCE TO PRODUCE A VACCINE 912 00:36:09,080 --> 00:36:10,000 THAT WENT ON TO BE APPROVED BY 913 00:36:10,000 --> 00:36:16,320 THE FDA. 914 00:36:16,320 --> 00:36:16,920 SO THE HARD WORK OF DEVELOPING 915 00:36:16,920 --> 00:36:24,360 THIS VACCINE HAPPEN FOR YEARS 916 00:36:24,360 --> 00:36:24,960 BEFORE THE PANDEMIC AND REALLY 917 00:36:24,960 --> 00:36:25,600 DIRECTLY DESCENDS FROM THE WORK 918 00:36:25,600 --> 00:36:30,440 ON HIV TO THE WORK ON RSV AND 919 00:36:30,440 --> 00:36:34,560 THEN TO THE CORONAVIRUS FOR 920 00:36:34,560 --> 00:36:39,040 THIS PANDEMIC AND INFLUENZA 921 00:36:39,040 --> 00:36:45,320 PHASE 1, -- NANO PARTICLE THAT 922 00:36:45,320 --> 00:36:47,320 AFFECTS THE STEM, AND ANOTHER 923 00:36:47,320 --> 00:36:50,440 VERSION OF THE SAME VACCINE, 924 00:36:50,440 --> 00:36:53,720 AND MRNA VACCINES THAT GENERATE 925 00:36:53,720 --> 00:36:55,560 THE SAME NANOPARTICLES THAT IS 926 00:36:55,560 --> 00:36:58,520 IN PHASE 1 TRIAL, INVOLVING OUR 927 00:36:58,520 --> 00:36:59,800 CIVICS PROGRAM. THIS WILL TAKE 928 00:36:59,800 --> 00:37:05,200 PLACE AT DUKE. 929 00:37:05,200 --> 00:37:05,800 ONE OR TWO OTHER QUICK RESULTS 930 00:37:05,800 --> 00:37:11,160 TO TELL YOU ABOUT. THIS WAS A 931 00:37:11,160 --> 00:37:14,200 TRIAL SHOWING POSTEXPOSURE 932 00:37:14,200 --> 00:37:14,840 DOXYCYCLINE, PREVENTS BACTERIA 933 00:37:14,840 --> 00:37:17,320 TRANSMITTED INFECTIONS WITHIN 934 00:37:17,320 --> 00:37:20,080 72 HOURS OF COMMON (CORRECTION) 935 00:37:20,080 --> 00:37:24,880 CONDOM LESS SEX, REDUCES TWO 936 00:37:24,880 --> 00:37:27,960 THIRDS OF THE GONORRHEA CASES. 937 00:37:27,960 --> 00:37:38,400 NOW SHOUT OUT TO -- -- OUR 938 00:37:45,640 --> 00:37:46,200 LOCAL GURU IN AUTOIMMUNE AND 939 00:37:46,200 --> 00:37:46,760 AUTO INFLAMMATORY DISEASES, 940 00:37:46,760 --> 00:37:48,040 THIS IS ONE OF THE GENETIC 941 00:37:48,040 --> 00:37:48,640 MUTATIONS SHE HAS DISCOVERED 942 00:37:48,640 --> 00:37:49,280 OVER THE YEARS AND FINALLY LET 943 00:37:49,280 --> 00:37:56,600 ME REMIND YOU THAT VAC LAST 944 00:37:56,600 --> 00:38:02,800 FALL, -- BECAME THE FIRST FDA 945 00:38:02,800 --> 00:38:05,600 APPROVED FOR DIABETES PATIENTS. 946 00:38:05,600 --> 00:38:11,800 APPROVAL CAME IN NOVEMBER, 2022 947 00:38:11,800 --> 00:38:12,360 BUT IT WAS THREE DECADES OF 948 00:38:12,360 --> 00:38:13,200 RESEARCH REQUIRED TO ADVANCE 949 00:38:13,200 --> 00:38:15,400 THIS CONCEPT, AND THE PEOPLE 950 00:38:15,400 --> 00:38:16,040 WHO DID THAT ARE SITTING AT THE 951 00:38:16,040 --> 00:38:21,680 TABLE THERE IT REALLY IS AN 952 00:38:21,680 --> 00:38:22,320 EXTRAORDINARY STORY OF RESEARCH 953 00:38:22,320 --> 00:38:30,840 OVER THE YEARS. 954 00:38:30,840 --> 00:38:31,400 I AM FINISHED AND I AM HAPPY 955 00:38:31,400 --> 00:38:32,040 TO TAKE QUESTIONS OR WE CAN AND 956 00:38:32,040 --> 00:38:32,680 HAVE MORE QUESTIONS AFTER STEVE 957 00:38:32,680 --> 00:38:34,400 HOLLAND PROCEEDS. YES? 958 00:38:34,400 --> 00:38:44,880 >>(OFF MIC) -- MY QUESTION WAS 959 00:38:50,480 --> 00:38:53,480 ABOUT THE NIH DIRECTOR BEING 960 00:38:53,480 --> 00:38:58,080 CONFIRMED. WHEN IS THE PROCESS 961 00:38:58,080 --> 00:38:59,640 SUPPOSED TO HAPPEN? AND 962 00:38:59,640 --> 00:39:01,520 HOPEFULLY IT WILL GO THROUGH 963 00:39:01,520 --> 00:39:02,640 WITHOUT ISSUE. WASN'T SHE 964 00:39:02,640 --> 00:39:06,800 CONFIRM AS THE MCIA? DIDN'T SHE 965 00:39:06,800 --> 00:39:07,280 HAVE TO GO TO SENATE 966 00:39:07,280 --> 00:39:16,280 CONFIRMATION FOR THE MCIA? 967 00:39:16,280 --> 00:39:16,800 >>THE CANCER DIRECTOR IS A 968 00:39:16,800 --> 00:39:17,400 PRESIDENTIAL APPOINTMENT AND 969 00:39:17,400 --> 00:39:21,440 THE CDC IS A RESIDENTIAL 970 00:39:21,440 --> 00:39:22,000 APARTMENT SO NONE GO TO THE 971 00:39:22,000 --> 00:39:22,640 SENATE CONFIRMATION SO MONICA 972 00:39:22,640 --> 00:39:23,840 HAS NOT BEEN PREVIOUSLY 973 00:39:23,840 --> 00:39:24,480 CONFIRMED BY THE SENATE SO THIS 974 00:39:24,480 --> 00:39:28,640 WILL BE HER FIRST REFER THAT. I 975 00:39:28,640 --> 00:39:29,280 CAN'T IMAGINE PERSONALLY COULD 976 00:39:29,280 --> 00:39:32,480 SHE WOULD NOT GET CONFIRMED 977 00:39:32,480 --> 00:39:33,080 EVENTUALLY BUT I KNOW IT WILL 978 00:39:33,080 --> 00:39:35,080 BE AN ENTIRELY PLEASANT PROCESS 979 00:39:35,080 --> 00:39:35,640 GIVEN SOME OF THE PEOPLE WE 980 00:39:35,640 --> 00:39:37,240 HAVE IN THE SENATE AND THEIR 981 00:39:37,240 --> 00:39:42,160 GRIPES ABOUT NIH. IT PUTS HER 982 00:39:42,160 --> 00:39:42,760 IN THE POSITION-- PUTS US IN 983 00:39:42,760 --> 00:39:47,720 THE POSITION-- THAT UNTIL THE 984 00:39:47,720 --> 00:39:48,320 SENATE CONFIRMATION ACTUALLY 985 00:39:48,320 --> 00:39:49,280 OCCURS NOBODY WANTS TO HAVE 986 00:39:49,280 --> 00:39:51,320 ANYTHING TO DO WITH DISCUSSING 987 00:39:51,320 --> 00:39:52,600 FUTURE PLANS FOR THE NIH WITH 988 00:39:52,600 --> 00:39:56,040 MONICA. THAT IS NOT DONE. WE 989 00:39:56,040 --> 00:39:56,600 DON'T WANT TO TARNISH THE 990 00:39:56,600 --> 00:40:01,200 PROCESS OLD (CORRECTION) SO 991 00:40:01,200 --> 00:40:10,240 LARRY TADEBACK IS STILL IN 992 00:40:10,240 --> 00:40:11,720 CHARGE AND IF I WERE HIM, I 993 00:40:11,720 --> 00:40:12,320 WILL BE IN COUPLE MAKING THE 994 00:40:12,320 --> 00:40:14,240 APPOINTMENT OF THE NIAID 995 00:40:14,240 --> 00:40:19,800 DIRECTOR UNTIL THE PERMANENT 996 00:40:19,800 --> 00:40:20,400 NIH DIRECTOR IS IN PLACE AND UP 997 00:40:20,400 --> 00:40:21,040 UNTIL THE TIME HE IS ALWAYS 998 00:40:21,040 --> 00:40:21,640 PROMISED ME I WILL PROCEED AS 999 00:40:21,640 --> 00:40:25,640 IF I WERE THE NIH DIRECTOR BUT 1000 00:40:25,640 --> 00:40:26,200 I THINK THE CHANGES TO GAME 1001 00:40:26,200 --> 00:40:26,840 WHEN YOU HAVE A NOMINEE IN THE 1002 00:40:26,840 --> 00:40:30,240 WAITING. 1003 00:40:30,240 --> 00:40:32,120 OKAY NEXT. WE ARE GOING TO 1004 00:40:32,120 --> 00:40:37,400 HEAR FROM DR. STEVEN HOLLAND, 1005 00:40:37,400 --> 00:40:38,000 ORDINARILY IN OUR SEQUENCE AT 1006 00:40:38,000 --> 00:40:38,600 THIS POINT WE WOULD ACTUALLY 1007 00:40:38,600 --> 00:40:43,480 HAVE HEARD FROM THE BRC 1008 00:40:43,480 --> 00:40:46,440 DIRECTOR BUT IT IS UNFAIR TO 1009 00:40:46,440 --> 00:40:48,680 TURN TO KEN PEARSON SEVERAL 1010 00:40:48,680 --> 00:40:50,480 WEEKS AWAY FROM BEING APPOINTED 1011 00:40:50,480 --> 00:40:51,120 TO THE JOB TO REPORT ON IT SO 1012 00:40:51,120 --> 00:40:54,160 DR. STEVEN HOLLAND HAS 1013 00:40:54,160 --> 00:40:54,800 GRACIOUSLY AGREED TO GO OUT OF 1014 00:40:54,800 --> 00:40:56,880 TURN TALK ABOUT THE BIR 1015 00:40:56,880 --> 00:41:00,760 PROGRAM. YOU HAVE BEEN THE 1016 00:41:00,760 --> 00:41:01,320 DIRECTOR OF THE INTRAMURAL 1017 00:41:01,320 --> 00:41:01,920 PROGRAM FOR SIX YEARS? 1018 00:41:01,920 --> 00:41:06,200 >>DR. HOLLAND: SEVEN NEXT 1019 00:41:06,200 --> 00:41:14,800 MONTH. 1020 00:41:14,800 --> 00:41:15,400 >>BEFORE STEVE TOOK OVER I WAS 1021 00:41:15,400 --> 00:41:16,840 THE ACTING DIRECTOR SO LOOKING 1022 00:41:16,840 --> 00:41:17,400 AT INTRAMURAL PROGRAM, AND 1023 00:41:17,400 --> 00:41:18,040 THOUGHT ABOUT IT FOR CLOSE TO A 1024 00:41:18,040 --> 00:41:20,200 YEAR AND WHAT I LEARNED IS THAT 1025 00:41:20,200 --> 00:41:22,960 THERE WAS NOT I WAS NOT AWARE 1026 00:41:22,960 --> 00:41:23,600 OF THAT NEEDED TO HAPPEN IN THE 1027 00:41:23,600 --> 00:41:25,920 INTRAMURAL PROGRAM AND HE HAS 1028 00:41:25,920 --> 00:41:26,560 REJUVENATED THE PROGRAM BOTH AT 1029 00:41:26,560 --> 00:41:27,960 THE HIGH LEADERSHIP LEVEL AND 1030 00:41:27,960 --> 00:41:30,560 AT THE YOUNGER LEVEL. 1031 00:41:30,560 --> 00:41:32,200 EXTRAORDINARY TO WATCH STEVE. 1032 00:41:32,200 --> 00:41:33,040 THANK YOU. 1033 00:41:33,040 --> 00:41:37,280 >>DR. HOLLAND: ALRIGHT SO LET 1034 00:41:37,280 --> 00:41:37,920 ME SEE IF I CAN GET MY SLIDES 1035 00:41:37,920 --> 00:41:43,200 UP. THE MISS THE BEGINNING 1036 00:41:43,200 --> 00:41:43,840 ALTHOUGH IT IS GREAT TO SEE ALL 1037 00:41:43,840 --> 00:41:44,400 OF YOU HERE IN PERSON WITH 1038 00:41:44,400 --> 00:41:47,200 MASKS OFF, IT WOULD BE SO MUCH 1039 00:41:47,200 --> 00:41:53,120 GREATER WITH COFFEE. I WANT TO 1040 00:41:53,120 --> 00:41:53,760 BE CLEAR THAT I DON'T THINK WE 1041 00:41:53,760 --> 00:41:54,800 HAVE ACHIEVED WHAT WE WANT IN 1042 00:41:54,800 --> 00:41:56,080 TERMS OF EMERGENCE FROM THE 1043 00:41:56,080 --> 00:41:58,760 PANDEMIC. (LAUGHTER). 1044 00:41:58,760 --> 00:42:04,360 I'M CONFIDENT WE CAN GET THERE. 1045 00:42:04,360 --> 00:42:04,920 I'M GOING TO TALK WITH YOU 1046 00:42:04,920 --> 00:42:05,920 BRIEFLY ABOUT THE SOME OF THE 1047 00:42:05,920 --> 00:42:06,560 THINGS THAT HAVE BEEN GOING ON 1048 00:42:06,560 --> 00:42:09,120 IN THE INTRAMURAL PROGRAM, AND 1049 00:42:09,120 --> 00:42:09,720 TRIED TO BE I THINK BRIEF AND 1050 00:42:09,720 --> 00:42:14,120 TO THE POINT. HUGH DISCOVERED 1051 00:42:14,120 --> 00:42:14,720 SOME OF THE HIGHLIGHTS AND I 1052 00:42:14,720 --> 00:42:15,240 WILL GO OVER THOSE VERY 1053 00:42:15,240 --> 00:42:18,680 QUICKLY. LET'S SEE HERE. 1054 00:42:18,680 --> 00:42:21,080 SO, JUST TO REMIND YOU THAT 1055 00:42:21,080 --> 00:42:24,000 FOR SOME OF YOU WHO HAVE NOT 1056 00:42:24,000 --> 00:42:26,920 BEEN ON THIS COMMITTEE BEFORE, 1057 00:42:26,920 --> 00:42:32,200 ALTHOUGH WE ARE AN INTRA-MURAL 1058 00:42:32,200 --> 00:42:32,800 PROGRAM, WE HAVE AT LEAST TWO 1059 00:42:32,800 --> 00:42:34,600 CAMPS IS HERE IN THIS COUNTRY. 1060 00:42:34,600 --> 00:42:35,160 HERE IN BETHESDA, AND OUR 1061 00:42:35,160 --> 00:42:36,600 PROGRAM IN MONTANA, IN HAMILTON 1062 00:42:36,600 --> 00:42:40,120 MONTANA. AND WE ARE ALSO 1063 00:42:40,120 --> 00:42:42,520 INTRAMURAL INTERNATIONAL. OUR 1064 00:42:42,520 --> 00:42:45,000 PROGRAMS AROUND THE WORLD 1065 00:42:45,000 --> 00:42:45,640 REALLY FORM THE BASIS FOR MANY 1066 00:42:45,640 --> 00:42:48,440 OF THE MOST CRITICAL ELEMENTS 1067 00:42:48,440 --> 00:42:49,800 OF THE INTRAMURAL PROGRAM. 1068 00:42:49,800 --> 00:42:55,360 SO, OF COURSE THERE ARE MANY 1069 00:42:55,360 --> 00:42:55,920 THINGS THAT DISTINGUISH THE 1070 00:42:55,920 --> 00:42:56,520 INTRAMURAL PROGRAM FROM THE 1071 00:42:56,520 --> 00:42:57,080 EXTRAMURAL PROGRAM. ONE OF 1072 00:42:57,080 --> 00:42:59,040 COURSE IS THE FENCE. I KNOW HOW 1073 00:42:59,040 --> 00:43:02,160 MUCH YOU ENJOYED THAT. THE 1074 00:43:02,160 --> 00:43:03,640 OTHERS ARE THAT WE HAVE 1075 00:43:03,640 --> 00:43:06,440 RETROSPECTIVE REVIEW OF 1076 00:43:06,440 --> 00:43:06,880 RESEARCH. AND THAT 1077 00:43:06,880 --> 00:43:07,440 RETROSPECTIVE REVIEW REALLY 1078 00:43:07,440 --> 00:43:10,600 DEPENDS ON THE BSC REVIEW OF 1079 00:43:10,600 --> 00:43:15,080 OUR INVESTIGATORS. EVERY FOUR 1080 00:43:15,080 --> 00:43:15,520 YEARS, EVERY SINGLE 1081 00:43:15,520 --> 00:43:20,480 INVESTIGATOR GETS REVIEWED. AND 1082 00:43:20,480 --> 00:43:21,080 IT IS CURRENTLY WE DO THIS 1083 00:43:21,080 --> 00:43:25,280 TWICE A YEAR ONE DECEMBER, ONCE 1084 00:43:25,280 --> 00:43:25,880 IN JUNE AND OTHER INSTITUTES DO 1085 00:43:25,880 --> 00:43:27,080 IT A LITTLE BIT DIFFERENTLY. I 1086 00:43:27,080 --> 00:43:27,720 THINK FOR THOSE OF YOU WHO HAVE 1087 00:43:27,720 --> 00:43:35,800 BEEN ON THE BSC, YOU WOULD 1088 00:43:35,800 --> 00:43:36,400 AGREE THAT IT IS GRUELING BUT 1089 00:43:36,400 --> 00:43:37,520 EXHILARATING COUPLE OF DAYS 1090 00:43:37,520 --> 00:43:38,120 WITH A LOT OF SIGNS AND A LOT 1091 00:43:38,120 --> 00:43:40,000 OF INTERVIEW TIME. AND WE TAKE 1092 00:43:40,000 --> 00:43:41,720 YOUR EVALUATIONS VERY 1093 00:43:41,720 --> 00:43:42,320 SERIOUSLY, AND WE APPRECIATE 1094 00:43:42,320 --> 00:43:45,680 THE INPUT THAT YOU GIVE. WE 1095 00:43:45,680 --> 00:43:46,280 REALLY STRIVE TO MAKE ALL OF 1096 00:43:46,280 --> 00:43:46,840 OUR WORK OUTSTANDING AND 1097 00:43:46,840 --> 00:43:48,040 IMPACTFUL. 1098 00:43:48,040 --> 00:43:50,240 AND FROM THAT EVALUATION, 1099 00:43:50,240 --> 00:43:53,240 REALLY EVERYTHING COMES UP. NOW 1100 00:43:53,240 --> 00:43:55,360 WHERE IS OUR INTRAMURAL 1101 00:43:55,360 --> 00:43:55,960 PROGRAM? OVER THE LAST THREE 1102 00:43:55,960 --> 00:43:57,840 YEARS AS YOU CAN SEE HERE, OUR 1103 00:43:57,840 --> 00:44:01,520 UNDULATIONS FROM 2012 TO THE 1104 00:44:01,520 --> 00:44:06,440 END OF THIS FISCAL YEAR. AND WE 1105 00:44:06,440 --> 00:44:08,760 ARE EXPERIENCING THE REALITY OF 1106 00:44:08,760 --> 00:44:09,280 MANY SENIOR INVESTIGATORS 1107 00:44:09,280 --> 00:44:11,360 DECIDING TO RETIRE. YOU'VE 1108 00:44:11,360 --> 00:44:13,640 HEARD OF TONY'S RETIREMENT BUT 1109 00:44:13,640 --> 00:44:15,360 MANY OTHERS HAVE COME. I WILL 1110 00:44:15,360 --> 00:44:18,000 SHOW YOU SOME OF THOSE. ARE 1111 00:44:18,000 --> 00:44:18,600 NUMBERS ARE DIPPING A LITTLE 1112 00:44:18,600 --> 00:44:23,440 BIT. WE ARE RECRUITING ANYTHING 1113 00:44:23,440 --> 00:44:25,520 VIGOROUSLY AT THE TENURE-TRACK 1114 00:44:25,520 --> 00:44:26,600 AND TENURE LEVEL, AND WE ARE 1115 00:44:26,600 --> 00:44:27,200 ALSO IN VIEW OF THE REALITIES 1116 00:44:27,200 --> 00:44:30,440 OF THE BUDGET TRYING TO 1117 00:44:30,440 --> 00:44:31,080 REDISTRIBUTE A LITTLE BIT WHAT 1118 00:44:31,080 --> 00:44:31,640 WE HAVE TO MAKE SURE THOSE 1119 00:44:31,640 --> 00:44:32,720 PROGRAMS THAT WE RETAIN ARE 1120 00:44:32,720 --> 00:44:33,960 DOING WELL. 1121 00:44:33,960 --> 00:44:39,640 BUT WE'VE GOT AROUND 120 1122 00:44:39,640 --> 00:44:41,640 INDIVIDUALS WHO ARE TENURED OR 1123 00:44:41,640 --> 00:44:42,440 TENURE-TRACK DOING THE CRITICAL 1124 00:44:42,440 --> 00:44:43,800 WORK HERE. 1125 00:44:43,800 --> 00:44:47,600 SO WHAT OUR PRIORITIES? ARE 1126 00:44:47,600 --> 00:44:49,600 GOAL IS TO DO TRANSFORMATIVE 1127 00:44:49,600 --> 00:44:51,280 MEDICINE AND RESEARCH. WE 1128 00:44:51,280 --> 00:44:51,880 REALLY TRY TO HAVE A BENCH TO 1129 00:44:51,880 --> 00:44:58,200 BEDSIDE APPROACH THAT TAKES 1130 00:44:58,200 --> 00:44:58,840 FULL ADVANTAGE OF THE CLINICAL 1131 00:44:58,840 --> 00:44:59,280 CENTER AS WELL AS THE 1132 00:44:59,280 --> 00:44:59,920 LABORATORIES AND FULL ADVANTAGE 1133 00:44:59,920 --> 00:45:00,480 OF THE FACT THAT THEY ARE 1134 00:45:00,480 --> 00:45:02,400 JUXTAPOSED. AND IF YOU WALK TO 1135 00:45:02,400 --> 00:45:05,760 BUILDING 10 YOU REALIZE THAT 1136 00:45:05,760 --> 00:45:06,280 OUR LABORATORIES AND OUR 1137 00:45:06,280 --> 00:45:06,800 CLINICS ARE IMMEDIATELY 1138 00:45:06,800 --> 00:45:08,520 ADJACENT TO EACH OTHER. 1139 00:45:08,520 --> 00:45:09,000 OF COURSE WE ARE VERY 1140 00:45:09,000 --> 00:45:12,000 INTERESTED IN PUBLIC HEALTH 1141 00:45:12,000 --> 00:45:12,520 THREATS, DRUG-RESISTANT 1142 00:45:12,520 --> 00:45:13,120 MICROBES, EMERGING VIRUSES, AND 1143 00:45:13,120 --> 00:45:14,440 THE VACCINES WE NEED TO COUNTER 1144 00:45:14,440 --> 00:45:18,760 THOSE. WE ARE TRYING TO PARTNER 1145 00:45:18,760 --> 00:45:22,200 BOTH INTRAMURALLY, AND 1146 00:45:22,200 --> 00:45:24,960 EXTRAMURALY HE AND WITH 1147 00:45:24,960 --> 00:45:27,200 INDUSTRY TO ENSURE THE WORK 1148 00:45:27,200 --> 00:45:28,600 GETS DONE THAT NEEDS TO BE DONE. 1149 00:45:28,600 --> 00:45:30,960 IN FY 23 WE HAVE 752 1150 00:45:30,960 --> 00:45:34,520 PUBLICATIONS AND 18 OF THOSE 1151 00:45:34,520 --> 00:45:35,080 HAVE BEEN PART OF OUR PRESS 1152 00:45:35,080 --> 00:45:38,440 RELEASE. AND WE HAD 200 1153 00:45:38,440 --> 00:45:40,920 CLINICAL STUDIES. 1154 00:45:40,920 --> 00:45:43,560 YOU HEARD HUGH TALK ABOUT 1155 00:45:43,560 --> 00:45:46,640 COVID FUNDING AND COVID 1156 00:45:46,640 --> 00:45:49,920 ACTIVITIES AND WHAT HAS THE 1157 00:45:49,920 --> 00:45:55,560 COVID BROUGHT TO THE INTRAMURAL 1158 00:45:55,560 --> 00:45:56,200 PROGRAM. OVER 60% OF THE PIS OF 1159 00:45:56,200 --> 00:45:56,800 THE PROGRAM HAVE PIVOTED SOME 1160 00:45:56,800 --> 00:46:01,440 OF THEIR WORK TO COVID 1161 00:46:01,440 --> 00:46:02,080 ACTIVITIES AND THAT MEANS THAT 1162 00:46:02,080 --> 00:46:02,680 80 INVESTIGATORS AND BRANCHES 1163 00:46:02,680 --> 00:46:05,920 HAVE BEEN INVOLVED. IN KNOW 1164 00:46:05,920 --> 00:46:06,440 THERE HAVE BEEN OVER 470 1165 00:46:06,440 --> 00:46:08,760 PUBLICATIONS AND YOU CAN SEE 1166 00:46:08,760 --> 00:46:09,360 THE TOP 10 JOURNALS THAT HAVE 1167 00:46:09,360 --> 00:46:10,600 BEEN TARGETED BY THESE. THIS 1168 00:46:10,600 --> 00:46:12,600 DOES NOT INCLUDE MANY OF THEM, 1169 00:46:12,600 --> 00:46:18,400 NOT INCLUDING BIO ARCHIVE AND 1170 00:46:18,400 --> 00:46:19,680 MED ARE CAPITAL OCCASIONALLY I 1171 00:46:19,680 --> 00:46:23,000 INCLINED TO DO SO. THERE'S 1172 00:46:23,000 --> 00:46:23,600 ABOUT 10 JOURNALS TO GIVE YOU 1173 00:46:23,600 --> 00:46:25,600 AN IDEA OF THE SCOPE OF WHAT WE 1174 00:46:25,600 --> 00:46:28,280 HAVE BEEN DOING. 1175 00:46:28,280 --> 00:46:28,840 ONE OF THE WAYS WE HAVE DONE 1176 00:46:28,840 --> 00:46:30,160 THAT HAS TRIED TO ENGAGE THE 1177 00:46:30,160 --> 00:46:30,800 ENTIRE INTRAMURAL PROGRAM, NOT 1178 00:46:30,800 --> 00:46:31,320 EVERYBODY WOKE UP IN THE 1179 00:46:31,320 --> 00:46:34,440 MORNING WITH A BSL-3 LABORATORY 1180 00:46:34,440 --> 00:46:36,080 THEY CAN TURN TO, AND SAY I 1181 00:46:36,080 --> 00:46:36,720 WANT TO TURN THESE GREAT IDEAS 1182 00:46:36,720 --> 00:46:42,280 INTO REALITY. TO MAKE THAT 1183 00:46:42,280 --> 00:46:42,840 WORK WE PARTNERED WITH TED 1184 00:46:42,840 --> 00:46:43,400 PEARSON WHEN HE WAS IN THE 1185 00:46:43,400 --> 00:46:46,880 INTRAMURAL PROGRAM, NOT THE BRC 1186 00:46:46,880 --> 00:46:50,640 PROGRAM AND RETURNED TO TED AND 1187 00:46:50,640 --> 00:46:51,200 SAID, HOW CAN WE MAKE THIS 1188 00:46:51,200 --> 00:46:53,600 HAPPEN? AND TED HAD THIS GREAT 1189 00:46:53,600 --> 00:46:56,080 IDEA TO SET UP THE SARS-COV-2 1190 00:46:56,080 --> 00:46:58,560 VIROLOGY CORE. AND THEN 1191 00:46:58,560 --> 00:47:01,320 RETURNED TO -- -- AND THE PUT 1192 00:47:01,320 --> 00:47:06,920 TOGETHER THIS CORE IN A BSL-3 1193 00:47:06,920 --> 00:47:07,560 FACILITY WHERE YOU CAN COME IN 1194 00:47:07,560 --> 00:47:15,040 AND DO THE WORK YOURSELF IF YOU 1195 00:47:15,040 --> 00:47:18,480 ARE SKILLED IN THAT OR YOU CAN 1196 00:47:18,480 --> 00:47:24,720 COME INTO REED AND NICOLE AND 1197 00:47:24,720 --> 00:47:25,360 OTHERS, WHO COULD HELP YOU TURN 1198 00:47:25,360 --> 00:47:26,000 THOSE IDEAS INTO REALITY AND WE 1199 00:47:26,000 --> 00:47:26,680 HAD SOME MAJOR PAPERS THAT HAVE 1200 00:47:26,680 --> 00:47:27,280 COME OUT OF THAT SHOWING THE 1201 00:47:27,280 --> 00:47:27,880 POWER AND IMPORTANCE OF BEING 1202 00:47:27,880 --> 00:47:28,880 READY TO PIVOT AND PARTNER WITH 1203 00:47:28,880 --> 00:47:29,400 PEOPLE WHO WERE READY TO 1204 00:47:29,400 --> 00:47:35,400 PARTNER. THIS IS NOT TRUE THAT 1205 00:47:35,400 --> 00:47:37,360 THIS IS A PARADIGM FOR WHAT 1206 00:47:37,360 --> 00:47:37,920 PANDEMIC PREPAREDNESS MIGHT 1207 00:47:37,920 --> 00:47:40,840 LOOK LIKE. 1208 00:47:40,840 --> 00:47:41,360 IN TERMS OF A COUPLE OF 1209 00:47:41,360 --> 00:47:41,960 UPDATES IN TERMS OF WHAT HAS 1210 00:47:41,960 --> 00:47:42,520 BEEN GOING ON IN OUR BUILT 1211 00:47:42,520 --> 00:47:44,680 ENVIRONMENT. WE HAVE BEEN 1212 00:47:44,680 --> 00:47:45,240 WORKING VIGOROUSLY OVER THE 1213 00:47:45,240 --> 00:47:49,360 LAST TWO YEARS TO RE-CREATE THE 1214 00:47:49,360 --> 00:47:54,440 RML ANIMAL FACILITY LOVINGLY 1215 00:47:54,440 --> 00:47:57,320 KNOWN AS BUILDING 34. IT IS NOT 1216 00:47:57,320 --> 00:47:57,920 A FLAW IN DESIGN THAT WE HAVE 1217 00:47:57,920 --> 00:48:02,000 HAD THESE LITTLE HOUSES 1218 00:48:02,000 --> 00:48:02,600 OUTSIDE. WE ARE GOING TO MOVE 1219 00:48:02,600 --> 00:48:03,200 THE PLUMBING INDOORS IN CASE 1220 00:48:03,200 --> 00:48:03,760 YOU ARE WORRIED ABOUT THAT 1221 00:48:03,760 --> 00:48:04,280 BEFORE WE ACTIVATE THE 1222 00:48:04,280 --> 00:48:04,680 BUILDING. 1223 00:48:04,680 --> 00:48:07,840 HERE ON THIS CAMPUS, THE 1224 00:48:07,840 --> 00:48:10,760 E-WING, THAT WHEN SHOWN HERE, 1225 00:48:10,760 --> 00:48:13,680 THIS IS OLD BUILDING 10. THIS 1226 00:48:13,680 --> 00:48:16,440 BUILDING HAS NOW BEEN TURNED 1227 00:48:16,440 --> 00:48:18,440 COMPLETELY INTO LABORATORY AND 1228 00:48:18,440 --> 00:48:23,120 OFFICE SPACE. THE E-WING HAS 1229 00:48:23,120 --> 00:48:25,240 BEEN GUTTED AND RENOVATED AS 1230 00:48:25,240 --> 00:48:30,200 PART OF THE ERA FUNDING AND 1231 00:48:30,200 --> 00:48:30,800 NOW WE ARE LOOKING TO OCCUPY 1232 00:48:30,800 --> 00:48:31,440 THE SPACE IN THE LATE SUMMER OF 1233 00:48:31,440 --> 00:48:33,320 THIS YEAR. IT SHOULD BE A REAL 1234 00:48:33,320 --> 00:48:36,360 TERRIFIC OPPORTUNITY; THIS IS 1235 00:48:36,360 --> 00:48:38,760 13 FLOORS OF RENOVATED SPACE 1236 00:48:38,760 --> 00:48:39,360 THAT SHOULD REALLY ALLOW THE 1237 00:48:39,360 --> 00:48:41,320 ENTIRE INTRAMURAL PROGRAM TO 1238 00:48:41,320 --> 00:48:43,760 MOVE ITS LABORATORIES FORWARD. 1239 00:48:43,760 --> 00:48:51,960 OF COURSE, MUCH MORE IMPORTANT 1240 00:48:51,960 --> 00:48:52,560 THAN OUR BUILT ENVIRONMENT IS 1241 00:48:52,560 --> 00:48:53,160 OUR HUMAN ENVIRONMENT, THERE 1242 00:48:53,160 --> 00:48:53,680 ARE MANY RETIREMENTS TO 1243 00:48:53,680 --> 00:48:55,680 MENTION, TONY FOUCI STEP DOWN 1244 00:48:55,680 --> 00:49:04,520 IN DECEMBER AND -- -- WHO HAD 1245 00:49:04,520 --> 00:49:05,080 BEEN DEPUTY DIRECTOR FOR 26 1246 00:49:05,080 --> 00:49:06,720 YEARS STEP DOWN IN FEBRUARY AND 1247 00:49:06,720 --> 00:49:09,760 HARMON CALDWELL WHO CAME HERE 1248 00:49:09,760 --> 00:49:11,480 FROM VACCINES STEP DOWN TO 1249 00:49:11,480 --> 00:49:14,960 NOVEMBER AND -- RETIRED IN 1250 00:49:14,960 --> 00:49:17,920 MARCH OF THIS YEAR AND BOB 1251 00:49:17,920 --> 00:49:18,480 MUNFORD, (PHONETIC), DEPUTY 1252 00:49:18,480 --> 00:49:19,800 CHIEF OF LABORATORY OF CLINICAL 1253 00:49:19,800 --> 00:49:21,720 IMMUNOLOGY AND MICROBIOLOGY 1254 00:49:21,720 --> 00:49:23,280 STEPPED DOWN IN DECEMBER AS DID 1255 00:49:23,280 --> 00:49:30,360 ALAN SHEAR (PHONETIC), CHIEF OF 1256 00:49:30,360 --> 00:49:31,880 LABORATORY OF PARASITIC 1257 00:49:31,880 --> 00:49:34,960 DISEASES. AND-- WILL BE 1258 00:49:34,960 --> 00:49:39,080 RETIRING LATER THIS YEAR. 1259 00:49:39,080 --> 00:49:42,400 AND THEN WE HAVE ALSO AT ROCKY 1260 00:49:42,400 --> 00:49:43,680 MOUNTAIN MULTIPLE RETIREMENTS, 1261 00:49:43,680 --> 00:49:47,400 ALL FOR THIS YEAR. JOHANNA BUSH 1262 00:49:47,400 --> 00:49:57,440 (PHONETIC) BOB HYSON, AND -- -- 1263 00:49:57,440 --> 00:49:58,960 AND WILL HAVE MAJOR 1264 00:49:58,960 --> 00:50:02,960 CELEBRATIONS IN MONTANA. 1265 00:50:02,960 --> 00:50:05,280 AND THERE ARE PARTNERSHIP NOT 1266 00:50:05,280 --> 00:50:05,880 RETIREMENTS. AS YOU HEARD TED 1267 00:50:05,880 --> 00:50:06,480 HAS GRACIOUSLY ACCEPTED TO TAKE 1268 00:50:06,480 --> 00:50:07,080 OVER AS THE DIRECTOR OF THE 1269 00:50:07,080 --> 00:50:09,680 BRC. THIS IS A VERY 1270 00:50:09,680 --> 00:50:12,680 BITTERSWEET PILL FOR ME 1271 00:50:12,680 --> 00:50:13,240 PERSONALLY. TED HAS BEEN A 1272 00:50:13,240 --> 00:50:15,160 TREMENDOUS COLLABORATOR AND 1273 00:50:15,160 --> 00:50:15,600 COLLEAGUE HERE IN THE 1274 00:50:15,600 --> 00:50:20,040 INTRAMURAL PROGRAM. IT IS ONLY 1275 00:50:20,040 --> 00:50:20,600 SOFTENED BY KNOWING THAT HE 1276 00:50:20,600 --> 00:50:21,320 WILL BE NOW A TREMENDOUS 1277 00:50:21,320 --> 00:50:24,840 COLLABORATOR IN THE BRC GIVES A 1278 00:50:24,840 --> 00:50:25,400 SIGH THING THE CHANCE TO 1279 00:50:25,400 --> 00:50:26,040 DEVELOP BETTER AND FURTHER 1280 00:50:26,040 --> 00:50:30,520 SYNERGIES MOVING FORWARD. AND 1281 00:50:30,520 --> 00:50:34,160 THEN AS HUGH MENTIONED -- IS 1282 00:50:34,160 --> 00:50:37,000 LEAVING HERE TO GO TO THE 1283 00:50:37,000 --> 00:50:38,520 PASTEUR INSTITUTE AND WILL 1284 00:50:38,520 --> 00:50:42,680 CONTINUE AND THE LABORATORIES 1285 00:50:42,680 --> 00:50:43,280 SHE FOUNDED THE LABORATORY OF 1286 00:50:43,280 --> 00:50:43,800 POST-IMMUNITY AND MICROBE 1287 00:50:43,800 --> 00:50:48,760 BIOME. THE LABORATORY WILL 1288 00:50:48,760 --> 00:50:49,400 STAY OPEN AND WE ARE RECRUITING 1289 00:50:49,400 --> 00:50:50,040 FOR A NEW CHIEF OF IT NOW AND I 1290 00:50:50,040 --> 00:50:51,960 ENCOURAGE YOU, IF YOU HAVE 1291 00:50:51,960 --> 00:50:52,560 OUTSTANDING INVESTIGATORS WITH 1292 00:50:52,560 --> 00:50:54,560 THE MICROBIOME INTEREST, WE ARE 1293 00:50:54,560 --> 00:50:56,600 VERY SERIOUS ABOUT CONTINUING 1294 00:50:56,600 --> 00:51:00,560 AND GROWING THIS PROGRAM. 1295 00:51:00,560 --> 00:51:03,800 AS PART OF OUR MOVING FORWARD 1296 00:51:03,800 --> 00:51:04,360 HUMAN ENVIRONMENT WE HAVE A 1297 00:51:04,360 --> 00:51:08,480 NEWLY TENURED INVESTIGATORS, 1298 00:51:08,480 --> 00:51:16,680 ANDREA -- AND -- IN THE 1299 00:51:16,680 --> 00:51:17,120 LABORATORY IN MONTANA 1300 00:51:17,120 --> 00:51:17,720 OUTSTANDING INVESTIGATORS IN 1301 00:51:17,720 --> 00:51:18,480 EMERGING AGENTS OF VIRAL 1302 00:51:18,480 --> 00:51:20,000 DISEASE. 1303 00:51:20,000 --> 00:51:21,360 WE HAVE SUCCESSFULLY AND VERY 1304 00:51:21,360 --> 00:51:22,880 ENTHUSIASTICALLY RECRUITED 1305 00:51:22,880 --> 00:51:30,400 DOCTOR RASSICA MATHIAS 1306 00:51:30,400 --> 00:51:31,000 (PHONETIC) FROM JOHNS HOPKINS 1307 00:51:31,000 --> 00:51:35,680 WHO WILL JOIN THE LABORATORY OF 1308 00:51:35,680 --> 00:51:36,280 -- DISEASES IN THE SECTION OF 1309 00:51:36,280 --> 00:51:36,880 GENOMICS HELP, WE EXPECTED TO 1310 00:51:36,880 --> 00:51:37,920 BE ON BOARD LATER THIS YEAR. 1311 00:51:37,920 --> 00:51:48,400 DOCTOR JENNIFER WEBSTER SIRIAC 1312 00:51:49,840 --> 00:51:50,400 (PHONETIC), DEPUTY DIRECTOR OF 1313 00:51:50,400 --> 00:51:50,960 THE DENTAL INSTITUTE AND IS 1314 00:51:50,960 --> 00:51:51,520 JOINED OUR INSTITUTE AS AN 1315 00:51:51,520 --> 00:51:52,120 ADJUNCT INVESTIGATORS PART OF 1316 00:51:52,120 --> 00:51:52,680 LABORATORY OF INFECTIOUS 1317 00:51:52,680 --> 00:51:57,640 DISEASES. SHE STUDYS HSV IN THE 1318 00:51:57,640 --> 00:52:01,040 SETTING OF HIV INFECTION. 1319 00:52:01,040 --> 00:52:05,120 A WORD ABOUT TENURE-TRACK. I'M 1320 00:52:05,120 --> 00:52:05,760 GOING TO MENTION THAT THERE ARE 1321 00:52:05,760 --> 00:52:07,280 THREE SEPARATE WAYS TO BE A 1322 00:52:07,280 --> 00:52:09,560 TENURED TRACK IN OUR COMMUNITY. 1323 00:52:09,560 --> 00:52:11,480 THERE IS A STRAIGHT LABORATORY 1324 00:52:11,480 --> 00:52:20,040 TENURE-TRACK POSITION OPEN, AND 1325 00:52:20,040 --> 00:52:20,600 THE EARL STATMAN (PHONETIC) 1326 00:52:20,600 --> 00:52:21,160 OPPORTUNITIES WHICH ARE FOR 1327 00:52:21,160 --> 00:52:25,920 BASIC SCIENTISTS, AND THE LAST 1328 00:52:25,920 --> 00:52:26,520 CLINICAL OPPORTUNITIES WHICH 1329 00:52:26,520 --> 00:52:27,080 ARE OPEN APPLICATIONS THAT 1330 00:52:27,080 --> 00:52:27,720 ALLOW PEOPLE TO BE INTRAMURAL 1331 00:52:27,720 --> 00:52:31,000 FOR FIVE YEARS AND PROVIDE 1332 00:52:31,000 --> 00:52:31,560 FUNDING FOR THREE YEARS OF 1333 00:52:31,560 --> 00:52:32,160 EXTRAMURAL ACTIVITIES SHOULD 1334 00:52:32,160 --> 00:52:33,880 THEY DECIDE TO GO OUTSIDE. 1335 00:52:33,880 --> 00:52:36,520 FOR ALL OF THESE, THERE ARE 1336 00:52:36,520 --> 00:52:37,080 THE POSSIBLE USE OF WHAT IS 1337 00:52:37,080 --> 00:52:38,440 CALLED THE DISTINGUISHED 1338 00:52:38,440 --> 00:52:41,800 SCHOLAR PROGRAM, WHICH IS 1339 00:52:41,800 --> 00:52:46,440 SUPPORTED IN PART BY BUILDING 1 1340 00:52:46,440 --> 00:52:49,600 TO RECOGNIZE YOUNG 1341 00:52:49,600 --> 00:52:50,240 INVESTIGATORS WHO ARE COMMITTED 1342 00:52:50,240 --> 00:52:50,720 TO A DIVERSE LABORATORY 1343 00:52:50,720 --> 00:52:52,680 ENVIRONMENT. AND THEY COME 1344 00:52:52,680 --> 00:52:54,640 WITH SOME COMPENSATION FROM 1345 00:52:54,640 --> 00:52:58,120 BUILDING 1 WHICH HELPS TO GET 1346 00:52:58,120 --> 00:52:58,720 THESE PEOPLE ESTABLISHED AND 1347 00:52:58,720 --> 00:53:01,160 OFF THE GROUND. 1348 00:53:01,160 --> 00:53:05,000 IN THAT CONTEXT, DOCTOR TIANA 1349 00:53:05,000 --> 00:53:11,960 EVANOVICH (PHONETIC) IS JOINING 1350 00:53:11,960 --> 00:53:12,560 US FROM BRANDEIS JOINING THE 1351 00:53:12,560 --> 00:53:13,280 LABORATORY OF VIRAL DISEASES 1352 00:53:13,280 --> 00:53:13,920 RECRUITED BY TED PEARSON BEFORE 1353 00:53:13,920 --> 00:53:24,440 HE LEFT, SHE HAS ALREADY BEEN 1354 00:53:25,080 --> 00:53:25,480 IDENTIFIED AS AN NIH 1355 00:53:25,480 --> 00:53:26,080 DISTINGUISHED SCHOLAR COLOR AND 1356 00:53:26,080 --> 00:53:26,680 SHE JUST JOINED LAST WEEK. WE 1357 00:53:26,680 --> 00:53:27,720 HAVE OTHER TENURE-TRACKS OPEN 1358 00:53:27,720 --> 00:53:29,960 AND GRIEVOUSLY THE LABORATORY 1359 00:53:29,960 --> 00:53:35,920 OF PERSISTENT VIRAL DISEASES-- 1360 00:53:35,920 --> 00:53:36,520 IN THE LABORATORY OF MALARIA 1361 00:53:36,520 --> 00:53:37,360 AND VECTOR RESEARCH AND IN THE 1362 00:53:37,360 --> 00:53:40,040 LABORATORY OF VIROLOGY. 1363 00:53:40,040 --> 00:53:40,600 IN ADDITION TO THAT WE HAVE 1364 00:53:40,600 --> 00:53:50,840 LABORATORY CHIEF POSITIONS 1365 00:53:50,840 --> 00:53:51,440 OPEN, IN THE LABORATORY OF 1366 00:53:51,440 --> 00:53:52,000 IMMUNE REGULATION; THIS WAS 1367 00:53:52,000 --> 00:53:54,040 THAT LABORATORY THE TONY HAS 1368 00:53:54,040 --> 00:53:54,600 BEEN CHIEF OFTEN WE ARE NOW 1369 00:53:54,600 --> 00:53:55,200 MERGING LABORATORY OF IMMUNE 1370 00:53:55,200 --> 00:53:55,840 REGULATION WITH THE LABORATORY 1371 00:53:55,840 --> 00:53:56,480 OF MOLECULAR BIOLOGY HEADED BY 1372 00:53:56,480 --> 00:53:59,560 MALCOLM MARTIN, AND WHEN WE 1373 00:53:59,560 --> 00:54:00,120 IDENTIFY THE DIRECTOR THAT 1374 00:54:00,120 --> 00:54:01,400 PERSON WILL OVERSEE BOTH 1375 00:54:01,400 --> 00:54:04,560 LABORATORIES. WE ARE WITHIN 1376 00:54:04,560 --> 00:54:05,200 SEVERAL WEEKS OF HAVING A LAST 1377 00:54:05,200 --> 00:54:05,880 INTERVIEW AND I HOPE TO BE ABLE 1378 00:54:05,880 --> 00:54:06,480 TO GET THAT DECIDED OVER THE 1379 00:54:06,480 --> 00:54:07,720 SUMMER. 1380 00:54:07,720 --> 00:54:09,440 THE LABORATORY OF VIRAL 1381 00:54:09,440 --> 00:54:13,280 DISEASES, AS YOU KNOW WITH 1382 00:54:13,280 --> 00:54:13,840 TED'S DEPARTURE THAT IS NOW 1383 00:54:13,840 --> 00:54:19,560 OPEN FOR A NEW RECRUIT. AND 1384 00:54:19,560 --> 00:54:20,040 THEN THE LABORATORY OF 1385 00:54:20,040 --> 00:54:20,640 POST-IMMUNITY AND MICROBIOME 1386 00:54:20,640 --> 00:54:21,280 WITH JASMINE'S DEPARTURE WILL 1387 00:54:21,280 --> 00:54:21,920 BE LOOKING FOR A NEW CHIEF AS 1388 00:54:21,920 --> 00:54:24,400 WELL. 1389 00:54:24,400 --> 00:54:29,920 FINALLY, THE DEPUTY DIRECTOR 1390 00:54:29,920 --> 00:54:33,680 TO ME IN MY OFFICE, WE JUST GOT 1391 00:54:33,680 --> 00:54:34,320 THE PUBLISHED LAST WEEK AND WE 1392 00:54:34,320 --> 00:54:34,920 ARE LOOKING FOR SOMEONE IN THE 1393 00:54:34,920 --> 00:54:35,560 SENIOR SCIENTIST OR SENIOR 1394 00:54:35,560 --> 00:54:38,920 CLINICIAN LEVEL. AND IF YOU 1395 00:54:38,920 --> 00:54:41,160 HAVE PEOPLE THAT WILL BE 1396 00:54:41,160 --> 00:54:41,760 INTERESTED, WE ARE VERY KEEN TO 1397 00:54:41,760 --> 00:54:43,160 LEARN ABOUT THEM. 1398 00:54:43,160 --> 00:54:46,520 NOW, I'M GOING TO GIVE A VERY 1399 00:54:46,520 --> 00:54:48,160 BRIEF HIGHLIGHT ON SOME OF THE 1400 00:54:48,160 --> 00:54:49,360 RESEARCH ACHIEVEMENTS IN THE 1401 00:54:49,360 --> 00:54:55,760 INTRAMURAL PROGRAM. HUGH HAS 1402 00:54:55,760 --> 00:54:56,400 TOUCHED ON A COUPLE OF THEM AND 1403 00:54:56,400 --> 00:54:57,640 I DON'T THINK ONE CAN EMPHASIZE 1404 00:54:57,640 --> 00:54:59,240 STRONGLY ENOUGH THE POWER OF 1405 00:54:59,240 --> 00:55:05,320 MONOCLONALS. MY GOD! THE LAST 1406 00:55:05,320 --> 00:55:05,880 FEW YEARS HAVE SHOWN US HOW 1407 00:55:05,880 --> 00:55:06,680 POTENT A DEVICE THOSE CAN BE 1408 00:55:06,680 --> 00:55:13,720 AND WHEN THEY ARE TURNED WITH 1409 00:55:13,720 --> 00:55:19,360 FULL FURY TARGETS IT IS AMAZING 1410 00:55:19,360 --> 00:55:19,960 WHAT WE CAN ACHIEVE AND THEN 1411 00:55:19,960 --> 00:55:20,560 THIS CONFORMITY WORK WITH BOB 1412 00:55:20,560 --> 00:55:26,880 SEDER AND -- -- THEY WERE ABLE 1413 00:55:26,880 --> 00:55:27,520 TO SHOW THIS DRAMATIC FOURFOLD 1414 00:55:27,520 --> 00:55:29,640 DROP IN THE RATE OF MALARIA. 1415 00:55:29,640 --> 00:55:31,440 THIS IS THE FIRST GENERATION OF 1416 00:55:31,440 --> 00:55:35,280 THEIR MONOCLONALS. MAN, THEY 1417 00:55:35,280 --> 00:55:39,880 ARE JUST BEGINNING TO FIGHT! IT 1418 00:55:39,880 --> 00:55:40,480 IS GOING TO BE AN ABSOLUTELY 1419 00:55:40,480 --> 00:55:42,520 GAME CHANGING TIME IN MALARIA. 1420 00:55:42,520 --> 00:55:47,000 USING THE SAME APPROACH, JEFF 1421 00:55:47,000 --> 00:55:47,640 COHEN AND HIS COWORKERS IN THE 1422 00:55:47,640 --> 00:55:48,160 LABORATORY OF INFECTIOUS 1423 00:55:48,160 --> 00:55:58,640 DISEASES GENERATED MULTIPLE 1424 00:56:03,000 --> 00:56:03,360 MONOCLONALS AGAINST 1425 00:56:03,360 --> 00:56:03,960 EPSTEIN-BARR BAR BUYERS WHICH 1426 00:56:03,960 --> 00:56:07,240 ALL WITHOUT SOME ACTIVITY, 1427 00:56:07,240 --> 00:56:07,880 WHICH COMPLETELY BLOCKED IT IN 1428 00:56:07,880 --> 00:56:13,240 THE MOUSE MODEL, WE ARE NOW 1429 00:56:13,240 --> 00:56:13,760 READY TO TAKE IT TO HUMAN 1430 00:56:13,760 --> 00:56:16,480 TRIALS IN THIS CAN BE USED IN 1431 00:56:16,480 --> 00:56:18,480 ANYTHING FROM LYMPHOMA TO 1432 00:56:18,480 --> 00:56:20,240 MULTIPLE SCLEROSIS. 1433 00:56:20,240 --> 00:56:20,720 HOW DO WE UNDERSTAND THE 1434 00:56:20,720 --> 00:56:22,520 VIRUSES THAT WE WORK WITH? WE 1435 00:56:22,520 --> 00:56:26,040 TALK ABOUT VACCINES, BUT HOW DO 1436 00:56:26,040 --> 00:56:26,680 WE KNOW WHAT THOSE VACCINES DO? 1437 00:56:26,680 --> 00:56:27,320 HIT AND MISS IS WONDERFUL WHEN 1438 00:56:27,320 --> 00:56:28,000 YOU HIT, BUT IT IS AN ANONYMOUS 1439 00:56:28,000 --> 00:56:28,600 WASTE OF TIME AND ENERGY WHEN 1440 00:56:28,600 --> 00:56:33,880 YOU DON'T. AUDREY HARRIS HAS 1441 00:56:33,880 --> 00:56:34,440 BEEN WORKING TO TAKE THE 1442 00:56:34,440 --> 00:56:34,960 VACCINES THAT ARE ALREADY 1443 00:56:34,960 --> 00:56:36,600 DEVELOPED AND FIGURE OUT WHY 1444 00:56:36,600 --> 00:56:38,400 THOSE THAT WORK, WORK, AND WHY 1445 00:56:38,400 --> 00:56:48,920 THOSE THAT DON'T, DON'T. SO 1446 00:56:54,600 --> 00:56:55,000 AUDREY HAS BEEN DOING 1447 00:56:55,000 --> 00:56:55,560 STRUCTURAL ANALYSIS OF THE 1448 00:56:55,560 --> 00:56:56,200 INFLUENZA VIRUS VACCINES-- THE 1449 00:56:56,200 --> 00:57:06,640 COMMERCIAL ONES THAT ARE 1450 00:57:10,760 --> 00:57:11,200 AVAILABLE. THIS FRUSBEE 1451 00:57:11,200 --> 00:57:11,760 LOOK-ALIKE TURNS OUT TO BE 1452 00:57:11,760 --> 00:57:13,480 QUITE IMPORTANT IN TERMS OF 1453 00:57:13,480 --> 00:57:14,240 BEING OF THE DISPLAY ANTIGENS. 1454 00:57:14,240 --> 00:57:14,720 IN TERMS OF WHAT WE ARE 1455 00:57:14,720 --> 00:57:17,720 WORRIED ABOUT, AS MENTIONED 1456 00:57:17,720 --> 00:57:26,440 HERE ANDREA MARTSE AND -- HAVE 1457 00:57:26,440 --> 00:57:33,600 BEEN DEVELOPING SUDAN VIRUS, 1458 00:57:33,600 --> 00:57:34,200 AND WE HAVE A VACCINE THAT IS 1459 00:57:34,200 --> 00:57:34,840 BEEN PROTECTED IN THE NONHUMAN 1460 00:57:34,840 --> 00:57:36,400 PRIVATE MODEL. 1461 00:57:36,400 --> 00:57:38,960 BERNIE MOSS WAS DEDICATED 1462 00:57:38,960 --> 00:57:42,040 REALLY ALMOST ALL OF HIS CAREER 1463 00:57:42,040 --> 00:57:42,520 TO THE D SECTION AND 1464 00:57:42,520 --> 00:57:50,520 UNDERSTANDING OF THE EPOX 1465 00:57:50,520 --> 00:57:51,120 VIRUSES, SOUNDS LIKE A SMALL 1466 00:57:51,120 --> 00:57:51,680 CONDITION BUT IF YOU DO NOT 1467 00:57:51,680 --> 00:57:52,320 HAVE A MODEL YOU CANNOT PREDICT 1468 00:57:52,320 --> 00:57:54,560 ANYTHING. AND BERNIE HAS BEEN 1469 00:57:54,560 --> 00:58:04,080 WORKING TO DEVELOP THE MODELS 1470 00:58:04,080 --> 00:58:04,720 IN WHICH WE CAN UNDERSTAND THE 1471 00:58:04,720 --> 00:58:05,280 VIRULENCE AND THE MOLECULAR 1472 00:58:05,280 --> 00:58:05,840 UNDERPINNINGS OF DIFFERENT 1473 00:58:05,840 --> 00:58:16,320 STRAINS OF MPOX, THOSE ARE 1474 00:58:17,040 --> 00:58:17,560 HIGHLY OF VIRULENT IN AFRICA 1475 00:58:17,560 --> 00:58:18,520 AND THOSE THAT EPIDEMIC AND 1476 00:58:18,520 --> 00:58:23,080 THOSE THAT ARE ENDEMIC, TO 1477 00:58:23,080 --> 00:58:23,680 UNDERSTAND WHAT ARE THE RIGHT 1478 00:58:23,680 --> 00:58:24,280 TARGETS AND ONE OF THE REAL 1479 00:58:24,280 --> 00:58:25,200 CULPRITS. 1480 00:58:25,200 --> 00:58:29,720 AS WE LOOK FURTHER INTO HOW 1481 00:58:29,720 --> 00:58:30,360 COVID HAS INFLUENCED OUR LIVES 1482 00:58:30,360 --> 00:58:32,080 OVER THE LAST FEW YEARS, ONE OF 1483 00:58:32,080 --> 00:58:32,680 THE WAYS IT IS INFLUENCED IS 1484 00:58:32,680 --> 00:58:37,200 IMMUNOLOGICALLY. AND AMONG THE 1485 00:58:37,200 --> 00:58:37,960 FASCINATING AND UNEXPECTED 1486 00:58:37,960 --> 00:58:44,400 OBSERVATIONS, JOHN SANG 1487 00:58:44,400 --> 00:58:44,840 (PHONETIC) A TERRIFIC 1488 00:58:44,840 --> 00:58:45,480 INVESTIGATOR HERE AND REMAINS A 1489 00:58:45,480 --> 00:58:46,080 TERRIFIC INVESTIGATOR AT YALE 1490 00:58:46,080 --> 00:58:47,400 WHERE HE LEFT TO GO LAST 1491 00:58:47,400 --> 00:58:51,840 SUMMER, JOHN AND RACHEL GOT 1492 00:58:51,840 --> 00:58:52,440 TOGETHER AND STUDIED PEOPLE WHO 1493 00:58:52,440 --> 00:58:55,280 HAD HAD COVID AND THEN WERE 1494 00:58:55,280 --> 00:58:58,720 VACCINATED AGAINST INFLUENZA. 1495 00:58:58,720 --> 00:58:59,160 AND THE FASCINATING 1496 00:58:59,160 --> 00:59:01,640 OBSERVATION, AS YOU SEE HERE, 1497 00:59:01,640 --> 00:59:09,680 AGAIN YOU WERE INFECTED WITH 1498 00:59:09,680 --> 00:59:10,160 COVID AND THEN YOU GET 1499 00:59:10,160 --> 00:59:10,800 VACCINATED AGAINST THE FLU AND 1500 00:59:10,800 --> 00:59:11,480 WHAT YOU SEE HERE IS THAT THERE 1501 00:59:11,480 --> 00:59:13,000 IS A SEXUAL DIMORPHISM OF 1502 00:59:13,000 --> 00:59:13,560 RESPONSE IN TERMS OF IMMUNE 1503 00:59:13,560 --> 00:59:17,040 RESPONSE TO THE INFLUENZA 1504 00:59:17,040 --> 00:59:17,680 VACCINE THAT DEPENDENT ON YOUR 1505 00:59:17,680 --> 00:59:21,360 PREVIOUS INFECTION WITH COVID. 1506 00:59:21,360 --> 00:59:23,840 BEGINNING TO HIGHLIGHT JUST HOW 1507 00:59:23,840 --> 00:59:24,480 COMPLICATED THESE INTERACTIONS 1508 00:59:24,480 --> 00:59:27,800 BETWEEN IMMUNE FUNCTION AND 1509 00:59:27,800 --> 00:59:28,360 VACCINE ADMINISTRATION ARE 1510 00:59:28,360 --> 00:59:31,000 GOING TO BE, IN THE FACT THAT 1511 00:59:31,000 --> 00:59:31,640 WE REALLY HAVE TO START TAKING 1512 00:59:31,640 --> 00:59:35,120 INTO ACCOUNT MANY DIFFERENT 1513 00:59:35,120 --> 00:59:35,720 VARIABLES, MANY MORE THAN WE 1514 00:59:35,720 --> 00:59:37,520 HAVE TAKEN ACCOUNT IN THE PAST. 1515 00:59:37,520 --> 00:59:41,360 MOVING ON AWAY FROM VIRUSES, I 1516 00:59:41,360 --> 00:59:41,960 KNOW THAT IS A PAIN TO SOME OF 1517 00:59:41,960 --> 00:59:43,560 YOU. BACTERIA ARE STILL 1518 00:59:43,560 --> 00:59:46,560 IMPORTANT. IT TURNS OUT THAT 1519 00:59:46,560 --> 00:59:47,240 YOU CAN INFLUENCE THE CARRIAGE 1520 00:59:47,240 --> 00:59:53,600 OF STAFF AUREUS BUT GIVEN 1521 00:59:53,600 --> 01:00:00,160 PEOPLE PROBIOTIC TREATMENT WITH 1522 01:00:00,160 --> 01:00:05,920 B -- -- AND THE FANTASTIC 1523 01:00:05,920 --> 01:00:06,480 WORKING TIME IN TRYING TO 1524 01:00:06,480 --> 01:00:07,080 UNDERSTAND HOW WE CAN USE THE 1525 01:00:07,080 --> 01:00:09,120 MICROBIOME TO MANIPULATE THE 1526 01:00:09,120 --> 01:00:09,720 MICROBIOME. AND WHAT YOU SEE 1527 01:00:09,720 --> 01:00:10,320 HERE IS THAT HE HAS BEEN ABLE 1528 01:00:10,320 --> 01:00:14,880 TO DEVELOP THIS B SUBTILIS 1529 01:00:14,880 --> 01:00:18,640 (PHONETIC) THERAPY THAT LOOKS 1530 01:00:18,640 --> 01:00:25,400 AT STAFF ARUEUS PRE AND POST 1531 01:00:25,400 --> 01:00:29,320 WITHOUT USING ANTIMICROBIALS. 1532 01:00:29,320 --> 01:00:29,920 TRYING TO CONTINUE ALONG WITH 1533 01:00:29,920 --> 01:00:30,560 THE UNDERSTANDING OF MODELS AND 1534 01:00:30,560 --> 01:00:33,160 HOW TO USE THEM, KAT HAIG 1535 01:00:33,160 --> 01:00:34,600 (PHONETIC) ONE OF THE 1536 01:00:34,600 --> 01:00:39,960 INVESTIGATORS IN THE MRL, HAS 1537 01:00:39,960 --> 01:00:42,840 BEEN INVESTIGATING ORGANOID, 1538 01:00:42,840 --> 01:00:45,760 AND USING THOSE IN INSOMNIA AND 1539 01:00:45,760 --> 01:00:46,360 TRYING TO UNDERSTAND HOW THAT 1540 01:00:46,360 --> 01:00:47,000 INFLUENCES METABOLISM AND WHAT 1541 01:00:47,000 --> 01:00:54,560 YOU CAN SEE HERE IS THAT THEY 1542 01:00:54,560 --> 01:00:55,080 BOTH HAVE FAMILIAL FATAL 1543 01:00:55,080 --> 01:01:05,600 INSOMNIA, IT BOTH DIMINISHES 1544 01:01:07,560 --> 01:01:08,120 DESPITE THE RATE AND BURST RATE 1545 01:01:08,120 --> 01:01:08,760 BUT INCREASES THE PERIODICITY, 1546 01:01:08,760 --> 01:01:10,680 IMPAIRS NEURONAL FUNCTION AND 1547 01:01:10,680 --> 01:01:18,680 INCREASES THE -- OF THIS FATAL 1548 01:01:18,680 --> 01:01:23,760 INSOMNIA. 1549 01:01:23,760 --> 01:01:24,280 IN LOOKING AT HOW NEURONAL 1550 01:01:24,280 --> 01:01:24,760 ACTIVITY INTERACT WITH 1551 01:01:24,760 --> 01:01:34,360 MICROBIOME, -- -- ANOTHER TOUR 1552 01:01:34,360 --> 01:01:34,880 DE FORCE IS SHOWN HOW THE 1553 01:01:34,880 --> 01:01:35,520 MICROBIOMIC CONTRIBUTION TO T 1554 01:01:35,520 --> 01:01:37,640 CELL ACTIVATION IN THE RESIDENT 1555 01:01:37,640 --> 01:01:38,160 AREAS OF THE SKIN THAT IS 1556 01:01:38,160 --> 01:01:43,920 INVOLVED IN THE GENERATION OF 1557 01:01:43,920 --> 01:01:44,480 IL-17A THAT HELPS NEURONS 1558 01:01:44,480 --> 01:01:52,120 REGENERATE AFTER THEIR DAMAGE 1559 01:01:52,120 --> 01:01:52,680 SO A COMPLEX INTERACTION 1560 01:01:52,680 --> 01:01:53,240 BETWEEN THE MICROBIOME AND 1561 01:01:53,240 --> 01:02:00,440 NEURONAL REGENERATION THAT IS 1562 01:02:00,440 --> 01:02:01,080 IMPORTANT AND IF WE THINK ABOUT 1563 01:02:01,080 --> 01:02:01,760 THE DRUGS WE USED TO MANIPULATE 1564 01:02:01,760 --> 01:02:02,320 DISEASES, AS WELL AS HOW WE 1565 01:02:02,320 --> 01:02:03,200 MANIPULATE MICROBIOME, THIS IS 1566 01:02:03,200 --> 01:02:03,840 AN IMPORTANT SET OF OBSERVATION 1567 01:02:03,840 --> 01:02:06,240 AS WE MOVE FORWARD. 1568 01:02:06,240 --> 01:02:10,640 LOOKING FURTHER AT THE 1569 01:02:10,640 --> 01:02:11,240 MICROBIOME, IAN MILES HAS TAKEN 1570 01:02:11,240 --> 01:02:11,840 THIS APPROACH TO A COMPLETELY 1571 01:02:11,840 --> 01:02:17,600 NOVEL LEVEL AT LEAST IN MY 1572 01:02:17,600 --> 01:02:18,240 UNDERSTANDING, LOOKING AT WHERE 1573 01:02:18,240 --> 01:02:18,840 DOES ATOPIC DERMATITIS HAPPEN 1574 01:02:18,840 --> 01:02:20,920 AND WHAT ARE THE THINGS IN THE 1575 01:02:20,920 --> 01:02:21,560 ENVIRONMENT AROUND THOSE PEOPLE 1576 01:02:21,560 --> 01:02:23,440 WHO GET ATOPIC DERMATITIS AND 1577 01:02:23,440 --> 01:02:29,520 HE HAS IDENTIFIED ISOCYANATES 1578 01:02:29,520 --> 01:02:30,120 AS POLLUTANTS THAT ALTER THE 1579 01:02:30,120 --> 01:02:30,720 MICROBIOME AND THE SKIN THAT 1580 01:02:30,720 --> 01:02:32,000 HAS TO DO WITH WHO DEVELOPS 1581 01:02:32,000 --> 01:02:34,640 ATOPIC DERMATITIS. REMARKABLE 1582 01:02:34,640 --> 01:02:41,840 PIECE OF WORK AND I REALLY-- 1583 01:02:41,840 --> 01:02:42,480 THIS PAPER IS EXCITING TO READ 1584 01:02:42,480 --> 01:02:46,440 AND IT IS GREAT TO HEAR IAN 1585 01:02:46,440 --> 01:02:48,240 PRESENT IT. 1586 01:02:48,240 --> 01:02:48,800 AND FINALLY AS AN EXAMPLE OF 1587 01:02:48,800 --> 01:02:49,560 WHAT THE INTRAMURAL PROGRAM CAN 1588 01:02:49,560 --> 01:02:50,600 DO AND HAS A PRIVILEGE TO DO, 1589 01:02:50,600 --> 01:02:51,200 THAT NOT ONLY DO WE GET TO DO 1590 01:02:51,200 --> 01:02:54,720 RETROSPECT THE RESEARCH, NOT 1591 01:02:54,720 --> 01:02:55,320 ONLY DO WE HAVE THE CLINICAL 1592 01:02:55,320 --> 01:02:55,840 CENTER BUT WE HAVE THE 1593 01:02:55,840 --> 01:02:56,480 PRIVILEGE OF DOING LONGITUDINAL 1594 01:02:56,480 --> 01:02:57,000 RESEARCH OVER PROLONGED 1595 01:02:57,000 --> 01:02:58,920 PERIODS. AND SO IN THIS COHORT 1596 01:02:58,920 --> 01:03:09,440 OF PATIENTS WITH CD4 LIPID-- 1597 01:03:20,040 --> 01:03:20,600 WHEN IDIOPATHIC LIPID -- BECAME 1598 01:03:20,600 --> 01:03:21,240 PANDEMIC, WE ATTRACTED PATIENT 1599 01:03:21,240 --> 01:03:21,840 TO SEE WHAT HAPPENED AND ALL 1600 01:03:21,840 --> 01:03:23,720 THE MORTALITY DOES NOT SEEM TO 1601 01:03:23,720 --> 01:03:24,200 BE VERY AFFECTED THE 1602 01:03:24,200 --> 01:03:25,960 SUSCEPTIBILITY TO CANCER IS 1603 01:03:25,960 --> 01:03:26,560 MARKEDLY INCREASED AND THOSE 1604 01:03:26,560 --> 01:03:34,600 PEOPLE WHO HAVE PROLONGED CD4 1605 01:03:34,600 --> 01:03:43,400 LYMPHOCYTOPAENIA. (PHONETIC). 1606 01:03:43,400 --> 01:03:44,000 I WILL STOP HERE TO SAY WE ARE 1607 01:03:44,000 --> 01:03:44,640 COMMITTED TO WHAT WE HAVE BEEN 1608 01:03:44,640 --> 01:03:45,240 COMMITTED TO DOING ALL THESE 1609 01:03:45,240 --> 01:03:45,840 YEARS AND RECRUIT TALENT AT A 1610 01:03:45,840 --> 01:03:49,760 LEVEL. WE WANT TO CONTINUE TO 1611 01:03:49,760 --> 01:03:50,280 SUPPORT OUTSTANDING BASIC 1612 01:03:50,280 --> 01:03:50,840 SCIENCE. AND I THINK IT IS 1613 01:03:50,840 --> 01:03:51,400 CRITICAL THAT WE USE OUR 1614 01:03:51,400 --> 01:03:53,720 CLINICAL CENTER AND OUR 1615 01:03:53,720 --> 01:03:54,360 OPPORTUNITIES TO MAKE SURE THAT 1616 01:03:54,360 --> 01:03:55,560 THAT BASIC SCIENCE HAS THE 1617 01:03:55,560 --> 01:04:01,920 OPPORTUNITY TO BE AS MARRIED AS 1618 01:04:01,920 --> 01:04:02,520 POSSIBLE TO THE CLINICAL SIGNS 1619 01:04:02,520 --> 01:04:05,600 THAT HE CAN INFLUENCE. 1620 01:04:05,600 --> 01:04:06,160 WE WANT TO MAKE SURE THAT THE 1621 01:04:06,160 --> 01:04:06,720 RESOURCES OF THE CHEMICAL 1622 01:04:06,720 --> 01:04:10,560 CENTER ARE AVAILABLE TO EACH 1623 01:04:10,560 --> 01:04:11,160 AND EVERY INVESTIGATOR WHO IS 1624 01:04:11,160 --> 01:04:12,680 INCLINED TO USE THEM; AND MAKE 1625 01:04:12,680 --> 01:04:13,160 SURE THAT WE PROMOTE 1626 01:04:13,160 --> 01:04:15,200 UNDERSTANDING OF 1627 01:04:15,200 --> 01:04:15,800 PATHOPHYSIOLOGY THAT IT STARTS 1628 01:04:15,800 --> 01:04:18,000 TO UNDERSTANDING TARGETS AND 1629 01:04:18,000 --> 01:04:18,560 APPROACHES. AND WE REMAINED 1630 01:04:18,560 --> 01:04:24,040 ENTHUSIASTIC AND VERY 1631 01:04:24,040 --> 01:04:26,400 ENCOURAGING OF INTRAMURAL, 1632 01:04:26,400 --> 01:04:27,000 EXTRAMURAL, AND INTERNATIONAL 1633 01:04:27,000 --> 01:04:27,600 COLLABORATION AND WELCOME ANY 1634 01:04:27,600 --> 01:04:30,240 AND ALL INQUIRIES IN THAT AREA. 1635 01:04:30,240 --> 01:04:31,120 THANK YOU VERY MUCH. 1636 01:04:31,120 --> 01:04:32,560 I'LL BE HAPPY TO TAKE 1637 01:04:32,560 --> 00:00:00,000 QUESTIONS.