1 00:00:05,480 --> 00:00:08,640 >>GOOD MORNING. 2 00:00:08,640 --> 00:00:09,880 IF THIS SEEMS WEIRD TO YOU, 3 00:00:09,880 --> 00:00:12,120 IMAGINE HOW I FEEL. 4 00:00:12,120 --> 00:00:13,560 I HAVE ATTENDED OVER 50 SESSIONS 5 00:00:13,560 --> 00:00:15,960 OF THE COUNCIL, AND I'VE ONLY 6 00:00:15,960 --> 00:00:18,720 OPENED MY MOUTH TO SPEAK ON ONE 7 00:00:18,720 --> 00:00:25,720 OCCASION WHEN DR. FAUCI WAS IN 8 00:00:25,720 --> 00:00:28,200 THAILAND RECEIVING AN AWARD, HE 9 00:00:28,200 --> 00:00:29,960 PRE-TAPED REMARKS BUT I HAD TO 10 00:00:29,960 --> 00:00:31,400 APPROVE THE MINUTES. 11 00:00:31,400 --> 00:00:32,920 YOU'LL HEAR MORE FROM ME TODAY 12 00:00:32,920 --> 00:00:34,240 THAN THAT. 13 00:00:34,240 --> 00:00:35,320 WE'RE MEETING VIRTUALLY TODAY AS 14 00:00:35,320 --> 00:00:37,520 WE PLAN TO DO EVERY JANUARY 15 00:00:37,520 --> 00:00:38,840 COUNCIL, REGARDLESS OF COVID 16 00:00:38,840 --> 00:00:39,280 STATUS. 17 00:00:39,280 --> 00:00:41,360 I WOULD BE VERY PLEASED IF WHEN 18 00:00:41,360 --> 00:00:43,000 IT COMES TO MAY IF A NEW 19 00:00:43,000 --> 00:00:44,000 PERMANENT DIRECTOR COULD MAKE 20 00:00:44,000 --> 00:00:46,320 THE DECISION THEN ABOUT WHETHER 21 00:00:46,320 --> 00:00:47,920 WE MEET IN PERSON. 22 00:00:47,920 --> 00:00:49,920 AS YOU KNOW, DURING THIS OPEN 23 00:00:49,920 --> 00:00:52,280 SESSION, WE'RE JOINED BY 24 00:00:52,280 --> 00:00:53,360 REPRESENTATIVES FROM 25 00:00:53,360 --> 00:00:54,480 PROFESSIONAL AND LAY 26 00:00:54,480 --> 00:00:55,680 ORGANIZATIONS WHO SHARE 27 00:00:55,680 --> 00:00:56,240 INTERESTS IN ACTIVITIES IN 28 00:00:56,240 --> 00:00:58,320 COMMON WITH THE MISSION OF THE 29 00:00:58,320 --> 00:00:59,520 INSTITUTE. 30 00:00:59,520 --> 00:01:02,040 AS ALWAYS, WE WELCOME THEM. 31 00:01:02,040 --> 00:01:03,440 NEXT SLIDE PLEASE. 32 00:01:03,440 --> 00:01:05,320 I WANT TO WELCOME SIX NEW 33 00:01:05,320 --> 00:01:07,440 COUNCIL MEMBERS WHO ARE JOINING 34 00:01:07,440 --> 00:01:08,840 US TODAY. 35 00:01:08,840 --> 00:01:10,800 EMILY BROWN IS A NATIONAL 36 00:01:10,800 --> 00:01:12,240 PATIENT ADVOCATE, FOUNDER AND 37 00:01:12,240 --> 00:01:14,440 CHIEF EXECUTIVE OFFICER OF FREE 38 00:01:14,440 --> 00:01:16,160 FROM MARKET, A DIGITAL HEALTH 39 00:01:16,160 --> 00:01:18,680 AND e-COMMERCE COMPANY, 40 00:01:18,680 --> 00:01:20,120 WORKING TO PROVIDE AFFORDABLE 41 00:01:20,120 --> 00:01:22,160 INCLUSIVE ACCESS TO THE FOODS 42 00:01:22,160 --> 00:01:24,560 AND RESOURCES PEOPLE NEED TO 43 00:01:24,560 --> 00:01:26,000 IMPROVE THEIR HEALTH. 44 00:01:26,000 --> 00:01:28,840 DR. MARY ESTES HOLDS THE CULLEN 45 00:01:28,840 --> 00:01:32,360 FOUNDATION ENDOWED CHAIR OF 46 00:01:32,360 --> 00:01:33,640 MOLECULAR AND HUMAN VIROLOGY, 47 00:01:33,640 --> 00:01:34,560 DISTINGUISHED SERVICE PROFESSOR, 48 00:01:34,560 --> 00:01:38,120 DEPARTMENT OF MOLECULAR BIOLOGY 49 00:01:38,120 --> 00:01:40,440 AND MICROBIOLOGY, DEPARTMENT OF 50 00:01:40,440 --> 00:01:41,560 MEDICINE, GASTROENTEROLOGY AND 51 00:01:41,560 --> 00:01:42,520 HEPATOLOGY AND INFECTIOUS 52 00:01:42,520 --> 00:01:45,920 DISEASES AT BAYLOR COLLEGE OF 53 00:01:45,920 --> 00:01:46,240 MEDICINE. 54 00:01:46,240 --> 00:01:49,080 DR. JAMES GERN IS PROFESSOR OF 55 00:01:49,080 --> 00:01:50,040 PEDIATRICS AND MEDICINE, 56 00:01:50,040 --> 00:01:50,680 UNIVERSITY OF WISCONSIN SCHOOL 57 00:01:50,680 --> 00:01:53,600 OF MEDICINE AND PUBLIC HEALTH IN 58 00:01:53,600 --> 00:01:55,440 MADISON, AND VICE CHAIR FOR 59 00:01:55,440 --> 00:01:58,800 RESEARCH IN DEPARTMENT OF 60 00:01:58,800 --> 00:01:59,120 PEDIATRICS. 61 00:01:59,120 --> 00:02:00,360 DR. LAWRENCE MOREL, PROFESSOR 62 00:02:00,360 --> 00:02:04,040 AND CHAIR OF DEPARTMENT OF 63 00:02:04,040 --> 00:02:05,040 MICROBIOLOGY, UNIVERSITY OF 64 00:02:05,040 --> 00:02:08,920 TEXAS HEALTH CENTER, SAN 65 00:02:08,920 --> 00:02:09,200 ANTONIO. 66 00:02:09,200 --> 00:02:12,280 DR. GUY PALMER IS PROFESSOR OF 67 00:02:12,280 --> 00:02:13,520 PATHOLOGY AND INFECTIOUS 68 00:02:13,520 --> 00:02:15,680 DISEASES, JAN AND JACK CREIGHTON 69 00:02:15,680 --> 00:02:17,920 ENDOWED CHAIR AT WASHINGTON 70 00:02:17,920 --> 00:02:19,000 STATE UNIVERSITY. 71 00:02:19,000 --> 00:02:21,280 GUY SERVES AS SENIOR DIRECTOR OF 72 00:02:21,280 --> 00:02:23,720 GLOBAL HEALTH FOR THE WASHINGTON 73 00:02:23,720 --> 00:02:24,480 STATE UNIVERSITY SYSTEM. 74 00:02:24,480 --> 00:02:26,920 WE ALSO HAVE A NEW EX OFFICIO 75 00:02:26,920 --> 00:02:29,880 MEMBER OF COUNCIL, DR. DANIEL 76 00:02:29,880 --> 00:02:31,960 JERNIGAN, ACTING DIRECTOR OF THE 77 00:02:31,960 --> 00:02:34,680 NATIONAL CENTER FOR EMERGING AND 78 00:02:34,680 --> 00:02:36,200 ZOONOTIC INFECTIOUS DISEASES AT 79 00:02:36,200 --> 00:02:36,440 CDC. 80 00:02:36,440 --> 00:02:37,400 WELCOME TO YOU ALL. 81 00:02:37,400 --> 00:02:39,920 WE'RE DELIGHTED TO HAVE YOU WITH 82 00:02:39,920 --> 00:02:40,720 US TODAY. 83 00:02:40,720 --> 00:02:42,440 THE FIRST ITEM OF BUSINESS IS TO 84 00:02:42,440 --> 00:02:44,000 REVIEW AND APPROVE THE MINUTES 85 00:02:44,000 --> 00:02:45,280 FROM THE LAST MEETING. 86 00:02:45,280 --> 00:02:46,640 YOU SHOULD ALREADY HAVE SEEN A 87 00:02:46,640 --> 00:02:48,480 COPY OF THE MINUTES IN THE 88 00:02:48,480 --> 00:02:49,560 ELECTRONIC COUNCIL BOOK. 89 00:02:49,560 --> 00:02:53,400 ARE THERE ANY CORRECTIONS TO THE 90 00:02:53,400 --> 00:02:53,840 MINUTES? 91 00:02:53,840 --> 00:02:55,240 ARE THERE ANY CONCERNS ABOUT 92 00:02:55,240 --> 00:02:56,360 CONCEPTS PRESENTED AT THE 93 00:02:56,360 --> 00:02:57,280 PREVIOUS MEETING? 94 00:02:57,280 --> 00:03:01,120 IF NOT, MAY I HAVE A MOTION FOR 95 00:03:01,120 --> 00:03:01,680 APPROVAL. 96 00:03:01,680 --> 00:03:02,120 >>SO MOVED. 97 00:03:02,120 --> 00:03:04,680 >>IS THERE A SECOND? 98 00:03:04,680 --> 00:03:04,960 >>SECOND. 99 00:03:04,960 --> 00:03:07,600 >>ALL THOSE IN FAVOR OF THE 100 00:03:07,600 --> 00:03:09,160 MINUTES PLEASE SAY AYE. 101 00:03:09,160 --> 00:03:09,480 >>AYE. 102 00:03:09,480 --> 00:03:09,800 >>AYE. 103 00:03:09,800 --> 00:03:10,600 >>AYE. 104 00:03:10,600 --> 00:03:11,000 >>AYE. 105 00:03:11,000 --> 00:03:11,360 >>AYE. 106 00:03:11,360 --> 00:03:12,600 >>ANY OPPOSED? 107 00:03:12,600 --> 00:03:16,600 THE MINUTES STAND AS APPROVED. 108 00:03:16,600 --> 00:03:21,240 THANK YOU. 109 00:03:21,240 --> 00:03:24,880 AS WE MOVE INTO THE MAIN BODY OF 110 00:03:24,880 --> 00:03:26,280 THE PRESENTATION, I WANT TO 111 00:03:26,280 --> 00:03:27,680 MENTION THAT WE'RE FOLLOWING A 112 00:03:27,680 --> 00:03:30,400 FORMAT THAT DR. FAUCI HAS USED 113 00:03:30,400 --> 00:03:31,120 FOR DECADES. 114 00:03:31,120 --> 00:03:34,920 IT INVOLVES WORK ON THE PART OF 115 00:03:34,920 --> 00:03:36,000 NUMEROUS EMPLOYEES OF NIAID BUT 116 00:03:36,000 --> 00:03:39,040 THEY ARE ALL WORKING ON UNDER 117 00:03:39,040 --> 00:03:40,720 THE DIRECTION OF GREG FOLKERS. 118 00:03:40,720 --> 00:03:42,240 MANY OF YOU NOT IN THE IMMEDIATE 119 00:03:42,240 --> 00:03:43,640 OFFICE OF THE DIRECTOR MAY NOT 120 00:03:43,640 --> 00:03:45,200 KNOW GREG. 121 00:03:45,200 --> 00:03:46,720 HE KEEPS A LOW PROFILE. 122 00:03:46,720 --> 00:03:48,440 BUT FOR 25 YEARS, HE HAS BEEN 123 00:03:48,440 --> 00:03:50,560 WORKING DIRECTLY FOR DR. FAUCI, 124 00:03:50,560 --> 00:03:54,360 AND I SUSPECT THAT THERE ARE 125 00:03:54,360 --> 00:03:55,360 FEW, IF ANY, PRESENTATIONS THAT 126 00:03:55,360 --> 00:03:57,680 HAVE COME OUT OF HIS OFFICE THAT 127 00:03:57,680 --> 00:03:59,480 HAVEN'T HAD THE FINGERPRINTS OF 128 00:03:59,480 --> 00:04:01,480 GREG FOLKERS. 129 00:04:01,480 --> 00:04:02,360 I MENTIONED HIM PARTICULARLY 130 00:04:02,360 --> 00:04:04,960 BECAUSE OF HIS KEY ROLE IN 131 00:04:04,960 --> 00:04:06,280 PREPARING THESE REMARKS BECAUSE 132 00:04:06,280 --> 00:04:09,360 TOMORROW IS HIS LAST DAY AS A 133 00:04:09,360 --> 00:04:10,200 FEDERAL EMPLOYEE. 134 00:04:10,200 --> 00:04:11,760 I WILL LATER SHOW A PICTURE OF 135 00:04:11,760 --> 00:04:13,600 HIM BUT IN FACT THAT IS GOING TO 136 00:04:13,600 --> 00:04:16,600 BE SOMETHING OF A THEME FOR THIS 137 00:04:16,600 --> 00:04:17,880 PRESENTATION, WE HAVE NUMEROUS 138 00:04:17,880 --> 00:04:19,000 TRANSITIONS AND I'M SURE OVER 139 00:04:19,000 --> 00:04:20,000 THE NEXT SEVERAL YEARS THERE 140 00:04:20,000 --> 00:04:23,840 WILL BE MORE TO COME. 141 00:04:23,840 --> 00:04:25,360 THE FIRST AND MOST SIGNIFICANT 142 00:04:25,360 --> 00:04:28,360 OF COURSE IS THE DEPARTURE FROM 143 00:04:28,360 --> 00:04:31,360 FEDERAL SERVICE OF TONY FAUCI. 144 00:04:31,360 --> 00:04:34,200 HE SERVED AS THE NIH NIAID 145 00:04:34,200 --> 00:04:38,080 DIRECTOR FOR 38 YEARS, AND SPENT 146 00:04:38,080 --> 00:04:40,000 54 YEARS AS NIAID 147 00:04:40,000 --> 00:04:40,760 PHYSICIAN-SCIENTIST. 148 00:04:40,760 --> 00:04:42,640 HE LEAVES AN INDELIBLE MARK ON 149 00:04:42,640 --> 00:04:44,200 SCIENCE AND GLOBAL HEALTH. 150 00:04:44,200 --> 00:04:46,480 HERE IS HOW PRESIDENT BIDEN PUT 151 00:04:46,480 --> 00:04:47,280 IT. 152 00:04:47,280 --> 00:04:49,200 BECAUSE OF DR. FAUCI'S MANY 153 00:04:49,200 --> 00:04:50,240 CONTRIBUTIONS TO PUBLIC HEALTH, 154 00:04:50,240 --> 00:04:51,520 LIVES HERE IN THE UNITED STATES 155 00:04:51,520 --> 00:04:54,240 AND AROUND THE WORLD HAVE BEEN 156 00:04:54,240 --> 00:04:54,440 SAVED. 157 00:04:54,440 --> 00:04:56,040 AS HE LEAVES HIS POSITION IN THE 158 00:04:56,040 --> 00:04:58,200 U.S. GOVERNMENT, I KNOW THE 159 00:04:58,200 --> 00:05:00,040 AMERICAN PEOPLE AND ENTIRE WORLD 160 00:05:00,040 --> 00:05:02,040 WILL CONTINUE TO BENEFIT FROM 161 00:05:02,040 --> 00:05:03,680 DR. FAUCI'S EXPERTISE IN 162 00:05:03,680 --> 00:05:04,680 WHATEVER HE DOES NEXT. 163 00:05:04,680 --> 00:05:07,960 WHETHER YOU MET HIM PERSONALLY 164 00:05:07,960 --> 00:05:11,040 OR NOT HE HAS TOUCHED ALL 165 00:05:11,040 --> 00:05:12,480 AMERICANS' LIVES WITH HIS WORK. 166 00:05:12,480 --> 00:05:13,720 I EXTEND MY DEEPEST THANKS FOR 167 00:05:13,720 --> 00:05:15,960 HIS PUBLIC SERVICE TO THE UNITED 168 00:05:15,960 --> 00:05:17,160 STATES OF AMERICA AND THE 169 00:05:17,160 --> 00:05:19,480 COUNTRY IS STRONGER FOR HIS 170 00:05:19,480 --> 00:05:22,560 SERVICE, MORE RESILIENT AND 171 00:05:22,560 --> 00:05:25,920 HEALTHIER BECAUSE OF HIM. 172 00:05:25,920 --> 00:05:28,000 ON DECEMBER 16, NIH STAGED A 173 00:05:28,000 --> 00:05:29,840 FAREWELL EVENT FOR DR. FAUCI, 174 00:05:29,840 --> 00:05:31,480 SHOWN IN THIS SLIDE HERE. 175 00:05:31,480 --> 00:05:34,800 WE HAD PRESENTATIONS FROM DR. 176 00:05:34,800 --> 00:05:37,640 LARRY TABAK, JOHN GALLIN, CLIFF 177 00:05:37,640 --> 00:05:39,680 LANE, FRANCIS COLLINS, AND 178 00:05:39,680 --> 00:05:42,680 CHRISTINE GRADY. 179 00:05:42,680 --> 00:05:44,320 AFTER THE TESTIMONIALS, NIH 180 00:05:44,320 --> 00:05:46,920 ACTING CHIEF OF STAFF JOHN 181 00:05:46,920 --> 00:05:48,800 BURKLOW IT A CONVERSATION ON 182 00:05:48,800 --> 00:05:51,520 STAGE WITH DR. FAUCI, REFLECTING 183 00:05:51,520 --> 00:05:54,480 ON HIS LONG AND REMARKABLE 184 00:05:54,480 --> 00:05:54,960 CAREER. 185 00:05:54,960 --> 00:05:57,200 FOLLOWING THAT, WE HAD CLOSING 186 00:05:57,200 --> 00:05:58,640 REMARKS FROM DR. FAUCI HIMSELF 187 00:05:58,640 --> 00:06:00,600 AND THE ENTIRE EVENT WAS VERY 188 00:06:00,600 --> 00:06:01,000 MOVING. 189 00:06:01,000 --> 00:06:04,320 YOU CAN SEE HERE THE STANDING 190 00:06:04,320 --> 00:06:09,160 OVATION AT THE COMPLETION OF 191 00:06:09,160 --> 00:06:10,640 THIS CEREMONY. 192 00:06:10,640 --> 00:06:12,320 NOW, YOU SHOULD KNOW THERE'S A 193 00:06:12,320 --> 00:06:14,400 GLOBAL SEARCH UNDERWAY TO FIND A 194 00:06:14,400 --> 00:06:16,560 REPLACEMENT FOR DR. FAUCI, AS 195 00:06:16,560 --> 00:06:17,720 THE INSTITUTE DIRECTOR. 196 00:06:17,720 --> 00:06:20,000 THE ANNOUNCEMENT WENT OUT ON 197 00:06:20,000 --> 00:06:21,960 NOVEMBER 16. 198 00:06:21,960 --> 00:06:22,960 CLOSING DATE WAS THEORETICALLY 199 00:06:22,960 --> 00:06:24,520 JANUARY 17 BUT IN FACT 200 00:06:24,520 --> 00:06:26,040 APPLICATIONS WILL BE ACCEPTED 201 00:06:26,040 --> 00:06:28,680 UNTIL THE POSITION IS FILLED. 202 00:06:28,680 --> 00:06:30,640 BUT JANUARY 17 WAS THE TIME AT 203 00:06:30,640 --> 00:06:33,200 WHICH THE SEARCH COMMITTEE CAN 204 00:06:33,200 --> 00:06:35,960 BEGIN REVIEWING THE APPLICATIONS 205 00:06:35,960 --> 00:06:38,400 AND BEGINNING TO DO INTERVIEWS. 206 00:06:38,400 --> 00:06:41,600 SO, THE PROCESS IS UNDERWAY. 207 00:06:41,600 --> 00:06:44,880 NOW I'M GOING TO TALK ABOUT 208 00:06:44,880 --> 00:06:48,400 OTHER HIGH LEVEL APPOINTMENTS 209 00:06:48,400 --> 00:06:50,560 AND DEPARTURES. 210 00:06:50,560 --> 00:06:57,600 FIRST IS RENEE, THE FIRST ARPA-H 211 00:06:57,600 --> 00:06:59,960 DIRECTOR, SHE COMES FROM A 212 00:06:59,960 --> 00:07:01,400 BIOTECH COMPANY IN BOSTON, BUT 213 00:07:01,400 --> 00:07:06,680 SHE'S WORKED IN THE PAST FOR 214 00:07:06,680 --> 00:07:07,760 DARPA AND THE IARPA, 215 00:07:07,760 --> 00:07:09,200 INTELLIGENCE ARPA, WELL FAMILIAR 216 00:07:09,200 --> 00:07:11,920 WITH THE PROGRAM SHE'S GOING TO 217 00:07:11,920 --> 00:07:12,880 BE LEADING AT ARPA-H. 218 00:07:12,880 --> 00:07:17,160 WE HAD THE OPPORTUNITY TO HEAR 219 00:07:17,160 --> 00:07:20,760 FROM HER THIS MORNING. 220 00:07:20,760 --> 00:07:28,800 SHE'S AGREED TO SHARE HER 221 00:07:28,800 --> 00:07:29,400 VISION. 222 00:07:29,400 --> 00:07:33,520 WE HAVE JONI RUTTER CHOSEN TO 223 00:07:33,520 --> 00:07:38,160 LEAD NCATS, ACTING DIRECTOR OF 224 00:07:38,160 --> 00:07:43,720 NCATS AND BEFORE THAT DEPUTY 225 00:07:43,720 --> 00:07:44,320 DIRECTOR. 226 00:07:44,320 --> 00:07:47,240 APPOINTMENT RECENTLY OF NINA 227 00:07:47,240 --> 00:07:49,080 SCHOR, DEPUTY DIRECTOR FOR 228 00:07:49,080 --> 00:07:50,080 INTRAMURAL RESEARCH REPLACING 229 00:07:50,080 --> 00:07:51,400 MICHAEL GOTTESMAN WHO STEPPED 230 00:07:51,400 --> 00:07:54,880 DOWN LAST AUGUST AFTER MANY 231 00:07:54,880 --> 00:07:55,280 YEARS. 232 00:07:55,280 --> 00:07:58,240 ROGER GLASS STEPPED DOWN AS THE 233 00:07:58,240 --> 00:07:59,160 DIRECTOR OF THE FOGARTY 234 00:07:59,160 --> 00:08:01,360 INTERNATIONAL CENTER, HE'S HELD 235 00:08:01,360 --> 00:08:04,120 THAT POSITION SINCE 2006, MAKING 236 00:08:04,120 --> 00:08:06,160 HIM THE LONGEST-SERVING DIRECTOR 237 00:08:06,160 --> 00:08:07,160 OF THE FOGARTY INTERNATIONAL 238 00:08:07,160 --> 00:08:09,800 CENTER, AND HE'S LEFT AN 239 00:08:09,800 --> 00:08:10,680 ENORMOUS MARK ON THE 240 00:08:10,680 --> 00:08:16,600 INTERNATIONAL PROGRAMS OF THE 241 00:08:16,600 --> 00:08:17,160 NIH. 242 00:08:17,160 --> 00:08:19,240 AND THE CENTRAL -- CENTER FOR 243 00:08:19,240 --> 00:08:21,000 INFORMATION TECHNOLOGY DIRECTOR 244 00:08:21,000 --> 00:08:23,480 AND CHIEF INFORMATION OFFICER 245 00:08:23,480 --> 00:08:25,240 ANDREA NORRIS HAS ALSO STEPPED 246 00:08:25,240 --> 00:08:28,320 DOWN FROM THAT POSITION, SHE HAS 247 00:08:28,320 --> 00:08:31,560 A $1.7 BILLION BUDGET TO PROVIDE 248 00:08:31,560 --> 00:08:33,440 INFORMATION TECHNOLOGY SERVICES 249 00:08:33,440 --> 00:08:39,880 TO THE INSTITUTES AT NIH. 250 00:08:39,880 --> 00:08:42,400 COMING TO NIAID GRAY HANDLEY, 251 00:08:42,400 --> 00:08:45,000 ASSOCIATE DIRECTOR FOR 252 00:08:45,000 --> 00:08:45,600 INTERNATIONAL RESEARCH AFFAIRS, 253 00:08:45,600 --> 00:08:50,120 RETIRED AT THE END OF LAST YEAR. 254 00:08:50,120 --> 00:08:52,520 GRAY CAME TO NIAID IN 2006, A 255 00:08:52,520 --> 00:08:53,960 FEW MONTHS AFTER I DID, AND OVER 256 00:08:53,960 --> 00:08:56,040 THE COURSE OF THE YEARS SINCE 257 00:08:56,040 --> 00:08:57,760 THEN WE TRAVELED THE WORLD 258 00:08:57,760 --> 00:09:00,640 TOGETHER, HE'S BECOME A CLOSE 259 00:09:00,640 --> 00:09:03,320 PERSONAL FRIEND, AND HE HAS 260 00:09:03,320 --> 00:09:05,880 GREATLY EXPANDED AND IMPROVED 261 00:09:05,880 --> 00:09:06,960 NIAID'S INTERNATIONAL PORTFOLIO. 262 00:09:06,960 --> 00:09:09,560 WHEN HE CAME TO ME AND TOLD ME 263 00:09:09,560 --> 00:09:12,560 HE WAS RETIRING, I SAID, PLEASE, 264 00:09:12,560 --> 00:09:14,160 GRAY, ONE MORE YEAR. 265 00:09:14,160 --> 00:09:16,040 HE SAID NO, THE TIME HAD COME, 266 00:09:16,040 --> 00:09:17,920 BUT HE HAS AGREED TO COME BACK 267 00:09:17,920 --> 00:09:21,320 AS A CONTRACTOR FOR SPECIAL 268 00:09:21,320 --> 00:09:21,600 PROJECTS. 269 00:09:21,600 --> 00:09:22,840 NOW, I MENTIONED GREG FOLKERS 270 00:09:22,840 --> 00:09:23,440 EARLIER. 271 00:09:23,440 --> 00:09:26,040 THIS IS A PICTURE OF HIM. 272 00:09:26,040 --> 00:09:28,000 HE WORKED DIRECTLY FOR DR. FAUCI 273 00:09:28,000 --> 00:09:31,080 FOR 25 YEARS. 274 00:09:31,080 --> 00:09:32,680 AND LORI DUPELL ALSO IN FEDERAL 275 00:09:32,680 --> 00:09:35,960 SERVICE FOR OVER 30 YEARS, AND 276 00:09:35,960 --> 00:09:38,120 IS A GIFTED EDITOR AND WRITER 277 00:09:38,120 --> 00:09:40,000 WORKING WITH DR. FAUCI FOR MANY 278 00:09:40,000 --> 00:09:42,840 YEARS NOW ON THE SCRIPTS OF THE 279 00:09:42,840 --> 00:09:45,480 MANY OF HIS REMARKS, AND OF SOME 280 00:09:45,480 --> 00:09:46,480 OF HIS PAPERS. 281 00:09:46,480 --> 00:09:48,760 THE TWO OF THEM HAVE AGREED TO 282 00:09:48,760 --> 00:09:51,960 COME BACK AS CONTRACTORS PARTLY 283 00:09:51,960 --> 00:09:53,240 WORKING FOR NIAID, BUT PROBABLY 284 00:09:53,240 --> 00:09:54,640 SPENDING MORE OF THEIR TIME 285 00:09:54,640 --> 00:09:57,000 ACTUALLY WORKING STILL FOR DR. 286 00:09:57,000 --> 00:10:01,800 FAUCI, IN HIS PRIVATE CAPACITY. 287 00:10:01,800 --> 00:10:04,880 IN THE DIVISION OF EXTRAMURAL 288 00:10:04,880 --> 00:10:06,600 ACTIVITIES, MATTHEW FENTON 289 00:10:06,600 --> 00:10:09,440 STEPPED DOWN AT THE END OF THE 290 00:10:09,440 --> 00:10:11,200 YEAR, KELLY POW IS NOW ACTING 291 00:10:11,200 --> 00:10:13,840 DIRECTOR OF THE DIVISION, A 292 00:10:13,840 --> 00:10:17,760 TUMULTUOUS TEN YEARS FOR 293 00:10:17,760 --> 00:10:22,360 MATTHEW, GIVEN ZIKA, EBOLA, MORE 294 00:10:22,360 --> 00:10:23,200 RECENTLY COVID OUTBREAKS KEPT 295 00:10:23,200 --> 00:10:27,920 HIS DIVISION WORKING EXTRA TIME 296 00:10:27,920 --> 00:10:29,600 THROUGHOUT HIS SERVICE. 297 00:10:29,600 --> 00:10:32,720 IN THE DIVISION OF EXTRAMURAL 298 00:10:32,720 --> 00:10:35,600 ACTIVITIES, GEORGE KENNEDY HAS 299 00:10:35,600 --> 00:10:38,240 BEEN NAMED THE DIRECTOR OF THE 300 00:10:38,240 --> 00:10:39,880 OFFICE OF ACQUISITIONS, HE HAS 301 00:10:39,880 --> 00:10:41,400 WORKED IN NUMEROUS PARTS OF THAT 302 00:10:41,400 --> 00:10:42,920 OFFICE OVER THE COURSE OF YEARS 303 00:10:42,920 --> 00:10:46,120 AND IS A REAL EXPERT ON 304 00:10:46,120 --> 00:10:47,320 GOVERNMENT CONTRACTING WHICH IS 305 00:10:47,320 --> 00:10:53,320 A GOOD THING BECAUSE HE'S 306 00:10:53,320 --> 00:10:53,960 REPLACING CHUCK GRUWE WHOSE 44 307 00:10:53,960 --> 00:10:58,800 YEARS OF SERVICE AS CONTRACTING 308 00:10:58,800 --> 00:11:01,000 OFFICER FOR NIAID MADE HIM A 309 00:11:01,000 --> 00:11:02,520 RECOGNIZED GURU IN THAT 310 00:11:02,520 --> 00:11:03,040 POSITION. 311 00:11:03,040 --> 00:11:13,320 WE HAVE BEEN FORTUNATE TO NAME 312 00:11:13,320 --> 00:11:17,840 DMID FOR THE RESPIRATORY DISEASE 313 00:11:17,840 --> 00:11:20,320 BRANCH MICHAEL ICEN FROM 314 00:11:20,320 --> 00:11:21,640 NORTHWEST UNIVERSITY, AN 315 00:11:21,640 --> 00:11:23,560 INTERNATIONALLY ACKNOWLEDGED 316 00:11:23,560 --> 00:11:28,000 EXPERT IN NUMEROUS RESPIRATORY 317 00:11:28,000 --> 00:11:31,160 VIRUSES AND OTHER PATHOGENS. 318 00:11:31,160 --> 00:11:33,360 WE'VE RECRUITED FOR DAIDS 319 00:11:33,360 --> 00:11:39,840 VERNON -- ANDREW VERNON AS CHIEF 320 00:11:39,840 --> 00:11:40,880 OF THE TB CLINICAL RESEARCH 321 00:11:40,880 --> 00:11:42,040 BRANCH AFTER A LONG CAREER AT 322 00:11:42,040 --> 00:11:45,280 CDC WHERE HE WORKED ON TB 323 00:11:45,280 --> 00:11:48,480 AFFAIRS ON A GLOBAL BASIS, WILL 324 00:11:48,480 --> 00:11:55,160 BRING ENORMOUS KNOWLEDGE TO THIS 325 00:11:55,160 --> 00:11:55,440 POSITION. 326 00:11:55,440 --> 00:12:00,080 IN THE DIVISION OF ALLERGY, 327 00:12:00,080 --> 00:12:03,160 IMMUNOLOGY, AND TRANSPLANTATION, 328 00:12:03,160 --> 00:12:05,000 JIM MCNAMARA HAS RETIRED, IN 329 00:12:05,000 --> 00:12:08,400 HIS -- UNDER HIS LEADERSHIP THE 330 00:12:08,400 --> 00:12:10,040 AUTOIMMUNITY CENTERS FOR 331 00:12:10,040 --> 00:12:11,240 EXCELLENCE REALLY CAME TOGETHER 332 00:12:11,240 --> 00:12:14,280 AS A FINELY TUNED NETWORK AND HE 333 00:12:14,280 --> 00:12:15,720 CONTRIBUTED GREATLY TO THE 334 00:12:15,720 --> 00:12:18,880 COURSE OF THE IMMUNE TOLERANCE 335 00:12:18,880 --> 00:12:19,240 NETWORK. 336 00:12:19,240 --> 00:12:22,160 EDEN GOLDMUNTZ IS NOW ACTING 337 00:12:22,160 --> 00:12:27,400 DIRECTOR OF THAT BRANCH, SHE HAS 338 00:12:27,400 --> 00:12:29,320 BEEN THE CHIEF OF 339 00:12:29,320 --> 00:12:30,080 RHEUMATOLOGICAL DISEASE SECTION 340 00:12:30,080 --> 00:12:40,440 IN THAT BRANCH FOR MANY YEARS. 341 00:12:40,440 --> 00:12:42,520 MARY SMOLSGUS IN CLINICAL 342 00:12:42,520 --> 00:12:44,840 RESEARCH IS LEAVING US -- EXCUSE 343 00:12:44,840 --> 00:12:47,120 ME, IS THE DIRECTOR OF THE 344 00:12:47,120 --> 00:12:55,760 OFFICE OF PLANNING AND 345 00:12:55,760 --> 00:12:56,520 OPERATIONS SUPPORT. 346 00:12:56,520 --> 00:12:57,360 >>ONE SECOND. 347 00:12:57,360 --> 00:13:01,440 >>IN THE DIVISION OF CLINICAL 348 00:13:01,440 --> 00:13:04,160 RESEARCH, MARY SMOLSKIS IS 349 00:13:04,160 --> 00:13:05,520 DIRECTOR OF OFFICE OF PLANNING 350 00:13:05,520 --> 00:13:06,920 AND OPERATIONS SUPPORT. 351 00:13:06,920 --> 00:13:09,320 SHE CAME TO NIAID AND NIH IN 352 00:13:09,320 --> 00:13:11,040 1985 AS A CLINICAL NURSE, SHE 353 00:13:11,040 --> 00:13:13,800 HAS GONE ON TO BECOME LEAD 354 00:13:13,800 --> 00:13:19,400 CLINICAL OPERATIONS MANAGER FOR 355 00:13:19,400 --> 00:13:22,560 CATCH THIS THE FLUENCE, EBOLA, 356 00:13:22,560 --> 00:13:32,120 SARS-COV-2, AND RUN STUDIES IN 357 00:13:32,120 --> 00:13:38,160 MEXICO, LIBERIA, GUINEA, CONGO 358 00:13:38,160 --> 00:13:41,400 AND MONGOLIA, SHE'S BEEN FAR AND 359 00:13:41,400 --> 00:13:42,560 WIDE. 360 00:13:42,560 --> 00:13:48,200 NOW CLIFF LANE RECEIVED THE 2022 361 00:13:48,200 --> 00:13:51,480 PAUL VOCHER CAREER ACHIEVEMENT 362 00:13:51,480 --> 00:13:53,840 MEDDLE AT HIS ANNUAL SERVICE TO 363 00:13:53,840 --> 00:13:54,960 AMERICA MEDALS, REFERRED TO BY 364 00:13:54,960 --> 00:13:58,720 PEOPLE IN THE KNOW AS THE 365 00:13:58,720 --> 00:13:59,920 SAMMYS, THE AWARD IS CONSIDERED 366 00:13:59,920 --> 00:14:06,920 THE OSCAR OF PUBLIC SERVICE. 367 00:14:06,920 --> 00:14:09,640 IN ADDITION, ALEX ROSENTHAL HAS 368 00:14:09,640 --> 00:14:11,600 BEEN RECOGNIZED BY PRESIDENTIAL 369 00:14:11,600 --> 00:14:15,120 RANK AWARD FOR HIS SERVICE AS 370 00:14:15,120 --> 00:14:16,800 THE NIAID CHIEF TECHNOLOGY 371 00:14:16,800 --> 00:14:17,000 OFFICER. 372 00:14:17,000 --> 00:14:20,600 THIS IS REALLY THE HIGHEST AWARD 373 00:14:20,600 --> 00:14:24,520 FOR CIVIL SERVANTS PROVIDED BY 374 00:14:24,520 --> 00:14:25,400 THE FEDERAL GOVERNMENT. 375 00:14:25,400 --> 00:14:30,880 I'M PLEASED TO TELL YOU THAT 376 00:14:30,880 --> 00:14:33,480 NIAID IS WINNER OF ONE OF THE 377 00:14:33,480 --> 00:14:34,880 PATENTS FOR HUMANITY AWARD, THIS 378 00:14:34,880 --> 00:14:37,440 WAS IN RECOGNITION OF THE WORK 379 00:14:37,440 --> 00:14:41,280 OF OUR TECHNOLOGY TRANSFER AND 380 00:14:41,280 --> 00:14:43,920 INTELLECTUAL PROPERTY OFFICE, 381 00:14:43,920 --> 00:14:47,520 WHICH WORKED HARD WITH THE 382 00:14:47,520 --> 00:14:48,480 INVESTIGATORS FROM VRC INCLUDING 383 00:14:48,480 --> 00:14:51,120 MARTY GRAHAM FOR THEIR WORK 384 00:14:51,120 --> 00:14:57,840 STABILIZING THE SPIKE PROTEIN OF 385 00:14:57,840 --> 00:14:59,040 CORONAVIRUS WITH S2P MUTATIONS. 386 00:14:59,040 --> 00:15:01,320 OVER THE YEARS, WE HAVE DONE 387 00:15:01,320 --> 00:15:02,880 WELL WITH SCIENCE MAGAZINE'S 388 00:15:02,880 --> 00:15:06,920 RECOGNITION OF TOP TEN 389 00:15:06,920 --> 00:15:08,440 BREAKTHROUGHS IN 2022 THAT 390 00:15:08,440 --> 00:15:10,320 AWARD, PRIME AWARD, WENT TO 391 00:15:10,320 --> 00:15:14,600 JAMES WEBB SPACE TELESCOPE. 392 00:15:14,600 --> 00:15:18,120 TWO RUNNER UP AWARDS RECOGNIZED 393 00:15:18,120 --> 00:15:19,880 RESEARCH BY NIH INVESTIGATORS, 394 00:15:19,880 --> 00:15:21,160 NIAID INVESTIGATORS, INCLUDING 395 00:15:21,160 --> 00:15:26,800 MARTY AND OTHERS' WORK ON 396 00:15:26,800 --> 00:15:27,800 RESPIRATORY SYNCYTIAL VACCINES, 397 00:15:27,800 --> 00:15:32,200 CLOSE TO APPROVAL WE BELIEVE, 398 00:15:32,200 --> 00:15:34,840 AND IMPLICATED EBV AS A 399 00:15:34,840 --> 00:15:36,080 POTENTIAL CAUSE OF MULTIPLE 400 00:15:36,080 --> 00:15:36,360 SCLEROSIS. 401 00:15:36,360 --> 00:15:38,960 ON DECEMBER 8 WE HAD THE 9th 402 00:15:38,960 --> 00:15:41,680 GLOBAL HEALTH WORKSHOP WITH THE 403 00:15:41,680 --> 00:15:45,320 GATES FOUNDATION, HERE AT NIH. 404 00:15:45,320 --> 00:15:47,160 AT THIS PLENARY SESSION AS YOU 405 00:15:47,160 --> 00:15:49,680 SEE HERE BILL GATES HIMSELF MADE 406 00:15:49,680 --> 00:15:55,160 KIND REMARKS ABOUT DR. FAUCI, IN 407 00:15:55,160 --> 00:15:56,560 ADDITION HAD TAPED TRIBUTES FROM 408 00:15:56,560 --> 00:15:59,840 PRESIDENT BILL CLINTON, W.H.O. 409 00:15:59,840 --> 00:16:05,240 DIRECTOR TEDROS, AND OUR FRIENDS 410 00:16:05,240 --> 00:16:06,200 FROM SOUTH AFRICA. 411 00:16:06,200 --> 00:16:11,120 IT WAS ANOTHER VERY MOVING 412 00:16:11,120 --> 00:16:11,400 CEREMONY. 413 00:16:11,400 --> 00:16:12,200 NIH AND THE GATES FOUNDATION 414 00:16:12,200 --> 00:16:14,480 HAVE COLLABORATED ON A NUMBER OF 415 00:16:14,480 --> 00:16:17,120 PROJECTS AND CONTINUE TO DO SO 416 00:16:17,120 --> 00:16:18,320 AFTER THIS MORNING PLENARY 417 00:16:18,320 --> 00:16:20,320 SESSION WE SPENT THE REST OF THE 418 00:16:20,320 --> 00:16:22,640 DAY MEETING TOGETHER TO TALK 419 00:16:22,640 --> 00:16:28,640 ABOUT PROGRESS IN OUR JOINT 420 00:16:28,640 --> 00:16:29,000 PROJECTS. 421 00:16:29,000 --> 00:16:30,600 THIS SLIDE HIGHLIGHTS SOME OF 422 00:16:30,600 --> 00:16:32,600 THE MEETINGS THAT WE, MEMBERS OF 423 00:16:32,600 --> 00:16:35,880 THE SENIOR LEADERSHIP, HAVE HAD 424 00:16:35,880 --> 00:16:36,800 WITH REPRESENTATIVES FROM 425 00:16:36,800 --> 00:16:38,400 FOREIGN COUNTRIES. 426 00:16:38,400 --> 00:16:39,280 WE'VE HAD IN-PERSON MEETINGS 427 00:16:39,280 --> 00:16:42,120 WITH VISITOR FROM THE U.K., 428 00:16:42,120 --> 00:16:44,000 CANADA, INDIA, EUROPEAN UNION, 429 00:16:44,000 --> 00:16:49,680 AUSTRALIA, POLAND, FRANCE, 430 00:16:49,680 --> 00:16:51,840 W.H.O., KOREA, MALI AND ELSE 431 00:16:51,840 --> 00:16:52,320 WHERE. 432 00:16:52,320 --> 00:17:01,520 THIS IS A PICTURE UPPER LEFT 433 00:17:01,520 --> 00:17:04,160 CORNER OF THE RECTOR OF THE 434 00:17:04,160 --> 00:17:05,240 UNIVERSITY IN VAMAKO WHICH WITH 435 00:17:05,240 --> 00:17:07,840 WE'VE HAD A RELATIONSHIP FOR 436 00:17:07,840 --> 00:17:09,640 MANY YEARS, WE MET WITH HIM AS 437 00:17:09,640 --> 00:17:11,440 WE HAVE WITH OTHER RECTORS OF 438 00:17:11,440 --> 00:17:12,440 THE UNIVERSITY, BUT HE BROUGHT 439 00:17:12,440 --> 00:17:15,520 WITH HIM ON THE LEFT THE TEAM OF 440 00:17:15,520 --> 00:17:17,160 SCIENTISTS THAT I WAS REALLY 441 00:17:17,160 --> 00:17:19,760 INTERESTED TO SEE SOME OF THOSE 442 00:17:19,760 --> 00:17:21,920 PEOPLE I'VE KNOWN FOR OVER 15 443 00:17:21,920 --> 00:17:24,080 YEARS, BACK IN THE DAYS WHEN 444 00:17:24,080 --> 00:17:25,720 THEY WERE POSTDOCS, WE'VE 445 00:17:25,720 --> 00:17:27,240 MAINTAINED RELATIONSHIP WITH 446 00:17:27,240 --> 00:17:27,600 THEM. 447 00:17:27,600 --> 00:17:29,000 ANOTHER IMPORTANT RELATIONSHIP 448 00:17:29,000 --> 00:17:32,520 IS SHOWN ON LOWER RIGHT-HAND 449 00:17:32,520 --> 00:17:34,280 CORNER, WHEN DR. GOGHALE, NEW 450 00:17:34,280 --> 00:17:35,920 SECRETARY OF THE INDIA 451 00:17:35,920 --> 00:17:37,880 DEPARTMENT OF BIOTECHNOLOGY, MET 452 00:17:37,880 --> 00:17:40,960 WITH DR. FAUCI WITH THE JOINT 453 00:17:40,960 --> 00:17:44,320 WORKING GROUP WHICH OVERSEES THE 454 00:17:44,320 --> 00:17:46,480 SO-CALLED VACCINE ACTION PROGRAM 455 00:17:46,480 --> 00:17:49,160 BETWEEN NIAID AND THE 456 00:17:49,160 --> 00:17:52,080 BIOTECHNOLOGY DEPARTMENT IN 457 00:17:52,080 --> 00:17:52,280 INDIA. 458 00:17:52,280 --> 00:17:53,200 THIS RELATIONSHIP SPANS 35 459 00:17:53,200 --> 00:17:55,080 YEARS, THE TWO OF THEM SIGNED 460 00:17:55,080 --> 00:18:01,440 THE DOCUMENT THAT MAINTAINS THE 461 00:18:01,440 --> 00:18:02,080 PROGRAM AS COLLABORATIONS 462 00:18:02,080 --> 00:18:03,520 THROUGH 2027. 463 00:18:03,520 --> 00:18:07,120 NOW WE'LL TURN TO EVERYBODY'S 464 00:18:07,120 --> 00:18:10,080 FAVORITE TOPIC, THE BUDGET 465 00:18:10,080 --> 00:18:10,320 UPDATE. 466 00:18:10,320 --> 00:18:11,920 STATUTORY LAW SAYS THAT ON THE 467 00:18:11,920 --> 00:18:14,000 FIRST MONDAY IN FEBRUARY, THE 468 00:18:14,000 --> 00:18:15,840 PRESIDENT'S BUDGET IN THIS CASE 469 00:18:15,840 --> 00:18:20,240 FOR 2024 WILL BE RELEASED. 470 00:18:20,240 --> 00:18:22,000 I'VE SEEN THAT DATE SLIP MANY 471 00:18:22,000 --> 00:18:23,720 TIMES AND I THINK WE'VE BEEN 472 00:18:23,720 --> 00:18:25,960 TOLD THAT WILL HAPPEN AGAIN. 473 00:18:25,960 --> 00:18:28,320 I DON'T KNOW WHAT IS IN THE 474 00:18:28,320 --> 00:18:29,640 PRESIDENT'S 2024 BUDGET AND I'M 475 00:18:29,640 --> 00:18:30,840 NOT ALLOWED TO TALK ABOUT IT IF 476 00:18:30,840 --> 00:18:32,720 I DID. 477 00:18:32,720 --> 00:18:36,080 SO LET'S TALK ABOUT FISCAL YEAR 478 00:18:36,080 --> 00:18:36,560 2023. 479 00:18:36,560 --> 00:18:38,760 THIS SLIDE SHOWS SOME KEY POINTS 480 00:18:38,760 --> 00:18:41,760 OF THE OMNIBUS BILL ENACTED IN 481 00:18:41,760 --> 00:18:42,400 DECEMBER OF 2023. 482 00:18:42,400 --> 00:18:43,480 AND THERE ARE TWO OR THREE 483 00:18:43,480 --> 00:18:44,760 THINGS I WANT TO DRAW YOUR 484 00:18:44,760 --> 00:18:46,520 ATTENTION TO. 485 00:18:46,520 --> 00:18:50,440 ONE IS THE 3.8% INCREASE FOR 486 00:18:50,440 --> 00:18:51,440 NIAID COMPARED TO 2022. 487 00:18:51,440 --> 00:18:53,720 AND I ONLY NOTE THAT BECAUSE 488 00:18:53,720 --> 00:18:57,560 YOU'LL SEE IT'S LOWER THAN THE 489 00:18:57,560 --> 00:19:01,160 AVERAGE INCREASE FOR OTHER NIH 490 00:19:01,160 --> 00:19:02,080 INSTITUTES AND CENTERS, WHICH 491 00:19:02,080 --> 00:19:04,000 I'VE NEVER SEEN BEFORE. 492 00:19:04,000 --> 00:19:05,320 WE USUALLY RUN SLIGHTLY HIGHER. 493 00:19:05,320 --> 00:19:06,840 AND I HAVE NO PARTICULAR 494 00:19:06,840 --> 00:19:07,720 EXPLANATION FOR THAT. 495 00:19:07,720 --> 00:19:10,280 I ALSO CALL YOUR ATTENTION TO 496 00:19:10,280 --> 00:19:12,240 THIS 10.6% INCREASE FOR THE 497 00:19:12,240 --> 00:19:14,280 OFFICE OF THE DIRECTOR. 498 00:19:14,280 --> 00:19:16,800 PARTLY FOR CYBERSECURITY, AND 499 00:19:16,800 --> 00:19:18,880 PARTLY TO EXPAND THE COMMON FUND 500 00:19:18,880 --> 00:19:19,240 PROGRAM. 501 00:19:19,240 --> 00:19:22,040 AND LASTLY, I WANT TO POINT OUT 502 00:19:22,040 --> 00:19:24,320 TO YOU PANDEMIC PREPAREDNESS 503 00:19:24,320 --> 00:19:26,120 DESPITE REQUESTS FOR FUNDS TO 504 00:19:26,120 --> 00:19:27,920 MOUNT A PANDEMIC PREPAREDNESS 505 00:19:27,920 --> 00:19:32,280 PROGRAM IN THE FUTURE, THERE WAS 506 00:19:32,280 --> 00:19:34,880 NO ALLOCATION FOR THIS PURPOSE. 507 00:19:34,880 --> 00:19:38,400 I MET WITH DR. FAUCI SHORTLY 508 00:19:38,400 --> 00:19:41,560 BEFORE HIS DEPARTURE, AND WE 509 00:19:41,560 --> 00:19:44,080 AGREED IT IS SIMPLY 510 00:19:44,080 --> 00:19:46,960 UNCONSCIONABLE FOR NIAID TO NOT 511 00:19:46,960 --> 00:19:47,720 HAVE PANDEMIC PREPAREDNESS 512 00:19:47,720 --> 00:19:49,560 PROGRAM COMING OFF THE COVID 513 00:19:49,560 --> 00:19:51,000 EXPERIENCE. 514 00:19:51,000 --> 00:19:54,160 YOU'LL HERE THE DMID -- THE 515 00:19:54,160 --> 00:19:55,240 SUBCOUNCIL WILL HEAR OUR PLANS 516 00:19:55,240 --> 00:19:56,560 FOR A PROGRAM WHICH WE'LL HAVE 517 00:19:56,560 --> 00:19:58,640 TO FUND OUT OF OUR OWN 518 00:19:58,640 --> 00:20:01,080 ALLOCATION AT THIS POINT FOR 519 00:20:01,080 --> 00:20:02,360 PANDEMIC PREPAREDNESS. 520 00:20:02,360 --> 00:20:04,760 THIS IS A SLIDE YOU'VE SEEN 521 00:20:04,760 --> 00:20:06,520 BEFORE WHICH SHOWS THE RELATIVE 522 00:20:06,520 --> 00:20:08,920 SIZE OF THE INSTITUTES ACCORDING 523 00:20:08,920 --> 00:20:11,360 TO THEIR BUDGETS, WE REMAIN 524 00:20:11,360 --> 00:20:12,440 SLIGHTLY SMALLER THAN NCI. 525 00:20:12,440 --> 00:20:14,160 IN MY TIME HERE THE TWO BALLOONS 526 00:20:14,160 --> 00:20:15,600 THAT HAVE GROWN THE LARGEST HAVE 527 00:20:15,600 --> 00:20:18,560 THE OFFICE OF THE DIRECTOR AND 528 00:20:18,560 --> 00:20:22,360 THE NATIONAL INSTITUTE OF AGING, 529 00:20:22,360 --> 00:20:24,920 RELATED TO INCREASED INTEREST IN 530 00:20:24,920 --> 00:20:29,280 ALZHEIMER'S DISEASE AS PEOPLE MY 531 00:20:29,280 --> 00:20:31,040 AGE GET OLDER. 532 00:20:31,040 --> 00:20:33,240 THIS SLIDE SHOWS THE NIAID 533 00:20:33,240 --> 00:20:35,840 FUNDING OVER THE ROUGHLY LAST 20 534 00:20:35,840 --> 00:20:36,280 YEARS. 535 00:20:36,280 --> 00:20:37,720 I ARRIVED ABOUT HERE, 536 00:20:37,720 --> 00:20:39,160 IMMEDIATELY WE HAD ABOUT 8 YEARS 537 00:20:39,160 --> 00:20:40,800 OF FLAT BUDGETS WHICH OF COURSE 538 00:20:40,800 --> 00:20:43,880 DIDN'T KEEP UP WITH INFLATION SO 539 00:20:43,880 --> 00:20:45,320 OUR ACTUAL SPENDING POWER WAS 540 00:20:45,320 --> 00:20:46,400 DECREASED DRAMATICALLY DURING 541 00:20:46,400 --> 00:20:47,480 THIS PERIOD OF TIME. 542 00:20:47,480 --> 00:20:51,200 FOR THE PAST 8 YEARS OR SO, THE 543 00:20:51,200 --> 00:20:54,960 FUNDING INCREASES HAVE BEEN MUCH 544 00:20:54,960 --> 00:20:55,520 BETTER. 545 00:20:55,520 --> 00:20:57,000 BEATING INFLATION SOME YEARS, 546 00:20:57,000 --> 00:20:58,440 MATCHING IT IN OTHERS. 547 00:20:58,440 --> 00:21:01,600 BUT NOT BY ANY MEANS MAKING UP 548 00:21:01,600 --> 00:21:05,880 TO THE LEVEL OF BUYING POWER WE 549 00:21:05,880 --> 00:21:07,200 HAD 20 YEARS AGO. 550 00:21:07,200 --> 00:21:10,280 AS A RESULT OF OUR BUDGET 551 00:21:10,280 --> 00:21:11,560 ALLOCATION, WE HAVE OUR 552 00:21:11,560 --> 00:21:12,480 FINANCIAL MANAGEMENT PLAN. 553 00:21:12,480 --> 00:21:14,400 YOU'VE SEEN THIS SLIDE BEFORE IN 554 00:21:14,400 --> 00:21:16,320 PREVIOUS YEARS. 555 00:21:16,320 --> 00:21:19,000 RIGHT NOW WE'RE WORKING ON THE 556 00:21:19,000 --> 00:21:20,520 11th PERCENTILE INTERIM PAY 557 00:21:20,520 --> 00:21:22,080 LINE, ENTER HIM PAYLINE I HOPE 558 00:21:22,080 --> 00:21:23,960 VERY MUCH IT'S GOING TO GET 559 00:21:23,960 --> 00:21:25,600 SLIGHTLY HIGHER BUT WILL NOT GET 560 00:21:25,600 --> 00:21:27,120 SUBSTANTIALLY HIGHER THIS YEAR. 561 00:21:27,120 --> 00:21:29,760 WE ALWAYS FUND THE NEW P.I.s 562 00:21:29,760 --> 00:21:31,600 AT HIGHER PERCENTILE. 563 00:21:31,600 --> 00:21:33,360 WE START AT 4% DIFFERENTIAL, BUT 564 00:21:33,360 --> 00:21:35,560 IN FACT WHAT WE SEEK IN THE END 565 00:21:35,560 --> 00:21:39,400 IS EQUAL SUCCESS RATE FOR NEW 566 00:21:39,400 --> 00:21:40,680 INVESTIGATORS COMPARED TO 567 00:21:40,680 --> 00:21:41,240 ESTABLISHED. 568 00:21:41,240 --> 00:21:44,040 WE NEVER HAVE ENGAGED IN 569 00:21:44,040 --> 00:21:45,240 DOWNWARD NEGOTIATIONS CUTTING 570 00:21:45,240 --> 00:21:46,080 NON-COMPETING AND COMPETING 571 00:21:46,080 --> 00:21:50,280 GRANTS, AND WE DO EACH YEAR TRY 572 00:21:50,280 --> 00:21:52,880 TO TRIM BACK COMPETING 573 00:21:52,880 --> 00:21:54,320 INITIATIVES AS MUCH AS 20% IN 574 00:21:54,320 --> 00:21:56,840 ORDER TO PRESERVE FUNDS FOR THE 575 00:21:56,840 --> 00:21:57,160 PAYLINE. 576 00:21:57,160 --> 00:21:57,920 ESTIMATED SUCCESS THIS YEAR WE 577 00:21:57,920 --> 00:22:00,320 EXPECT TO BE IN THE RANGE OF 18 578 00:22:00,320 --> 00:22:02,520 TO 22% WHICH IS CLOSE TO WHERE 579 00:22:02,520 --> 00:22:07,760 IT HAS BEEN IN PREVIOUS YEARS. 580 00:22:07,760 --> 00:22:10,280 YOU SHOULD UNDERSTAND THAT OUR 581 00:22:10,280 --> 00:22:13,680 BUDGET COMES WITH SUBSTANTIAL 582 00:22:13,680 --> 00:22:15,320 EARMARKS. 583 00:22:15,320 --> 00:22:19,680 PARTICULARLY FOR ANTIMICROBIAL 584 00:22:19,680 --> 00:22:21,280 RESISTANCE, UNIVERSAL INFLUENZA 585 00:22:21,280 --> 00:22:24,080 VACCINE, AND SET ASIDE FOR 586 00:22:24,080 --> 00:22:25,160 REGIONAL BIOCONTAINMENT 587 00:22:25,160 --> 00:22:26,320 LABORATORIES. 588 00:22:26,320 --> 00:22:28,120 THESE ARE ALL IMPORTANT 589 00:22:28,120 --> 00:22:30,840 PRIORITIES FOR THE INSTITUTE, 590 00:22:30,840 --> 00:22:33,360 NONETHELESS WHEN YOU HAVE ALMOST 591 00:22:33,360 --> 00:22:35,800 $2 BILLION OF YOUR BUDGET SET 592 00:22:35,800 --> 00:22:38,000 ASIDE FOR AIDS, AND ALMOST A 593 00:22:38,000 --> 00:22:39,960 BILLION DOLLARS OF OTHER 594 00:22:39,960 --> 00:22:42,360 EARMARKS THAT MEANS THE VERY 595 00:22:42,360 --> 00:22:45,640 SUBSTANTIAL CLOSE TO 50% OF YOUR 596 00:22:45,640 --> 00:22:48,400 OVERALL BUDGET IS ALREADY 597 00:22:48,400 --> 00:22:52,880 ENCUMBERED LEAVING VERY REDUCED 598 00:22:52,880 --> 00:22:54,000 FLEXIBILITY. 599 00:22:54,000 --> 00:22:56,560 I JUST WANT TO MENTION THE FUNDS 600 00:22:56,560 --> 00:22:58,000 WE'VE RECEIVED FOR COVID 601 00:22:58,000 --> 00:23:00,160 PURPOSES DURING THE LAST SEVERAL 602 00:23:00,160 --> 00:23:00,840 YEARS. 603 00:23:00,840 --> 00:23:03,240 BACK IN MARCH OF 2022, WE GOT 604 00:23:03,240 --> 00:23:07,440 TWO SUPPLEMENTS THAT CAME TO A 605 00:23:07,440 --> 00:23:08,960 TOTAL OF ABOUT $1.5 BILLION TO 606 00:23:08,960 --> 00:23:14,320 SPEND LARGELY RESEARCH INVOLVIG 607 00:23:14,320 --> 00:23:15,800 VACCINES AND THERAPEUTICS AND 608 00:23:15,800 --> 00:23:18,440 BASIC PATHOGENESIS. 609 00:23:18,440 --> 00:23:20,520 THIS MONEY HAS ESSENTIALLY BEEN 610 00:23:20,520 --> 00:23:24,360 EXPENDED, IT'S GOOD UNTIL 2024, 611 00:23:24,360 --> 00:23:28,000 THERE'S $20 TO $30 MILLION NOT 612 00:23:28,000 --> 00:23:30,600 EARMARKED AT THIS POINT. 613 00:23:30,600 --> 00:23:35,320 WE ALSO RECEIVED FUNDS TO A 614 00:23:35,320 --> 00:23:36,240 VARIETY OF MECHANISMS, OPERATION 615 00:23:36,240 --> 00:23:41,440 WARP SPEED, AND MOST RECENTLY 616 00:23:41,440 --> 00:23:42,080 CALLED H-CORE WHICH FUNNELS 617 00:23:42,080 --> 00:23:44,280 MONEY FROM THE DEPARTMENT TO 618 00:23:44,280 --> 00:23:47,000 BARDA AND OTHER AGENCIES 619 00:23:47,000 --> 00:23:48,160 INCLUDING NIAID, IN TOTAL OF 620 00:23:48,160 --> 00:23:49,520 THAT FUNDING OVER THE COURSE OF 621 00:23:49,520 --> 00:23:52,440 THE PAST THREE YEARS NOW IS IN 622 00:23:52,440 --> 00:23:53,840 THE RANGE OF $3.4 MILLION, AND 623 00:23:53,840 --> 00:23:56,200 THAT MONEY HAS BEEN USED IN PART 624 00:23:56,200 --> 00:23:57,680 TO FUND THE CLINICAL TRIALS THAT 625 00:23:57,680 --> 00:24:02,560 LED TO APPROVAL OF OUR VACCINES 626 00:24:02,560 --> 00:24:05,880 IN PART FUNDING SOME CENTERS TO 627 00:24:05,880 --> 00:24:07,720 DEVELOP NEW THERAPEUTICS, IT'S 628 00:24:07,720 --> 00:24:13,320 FUNDED STUDIES ON VARIANTS AND 629 00:24:13,320 --> 00:24:15,360 THEIR SUSCEPTIBLITY TO VACCINES 630 00:24:15,360 --> 00:24:16,440 AND BOOSTER SHOTS. 631 00:24:16,440 --> 00:24:18,360 WE'RE STILL SHORT OF FUNDING FOR 632 00:24:18,360 --> 00:24:20,200 THE ACTIVITIES THAT WE NEED TO 633 00:24:20,200 --> 00:24:24,880 DO AS PART OF THE COVID 634 00:24:24,880 --> 00:24:25,280 RESPONSE. 635 00:24:25,280 --> 00:24:26,560 NOW LEGISLATIVE UPDATE. 636 00:24:26,560 --> 00:24:27,840 THERE'S OF COURSE HEARINGS 637 00:24:27,840 --> 00:24:31,480 AGAIN, THERE'S A HELP HEARING ON 638 00:24:31,480 --> 00:24:33,480 SEPTEMBER 14 IN 2022, LARGELY ON 639 00:24:33,480 --> 00:24:35,640 WHAT WE USED TO CALL MONKEYPOX 640 00:24:35,640 --> 00:24:38,600 BUT NOW OFFICIALLY TERMED 641 00:24:38,600 --> 00:24:42,640 Mpox, BUT THE CONVERSATION AND 642 00:24:42,640 --> 00:24:44,640 QUESTIONS WENT BEYOND MONKEYPOX 643 00:24:44,640 --> 00:24:48,040 INTO OTHER AREAS. 644 00:24:48,040 --> 00:24:49,880 THE CONGRESSIONAL CAUCUS, HIV 645 00:24:49,880 --> 00:24:52,960 CAUCUS ON WORLD AIDS DAY, HELD A 646 00:24:52,960 --> 00:24:54,040 RECEPTION WITH SOME PARTNERS 647 00:24:54,040 --> 00:24:57,760 THAT HONORED DR. FAUCI FOR HIS 648 00:24:57,760 --> 00:25:00,920 LONG MANY CONTRIBUTIONS TO HIV. 649 00:25:00,920 --> 00:25:03,480 MANY OTHER MEMBERS OF OUR STAFF 650 00:25:03,480 --> 00:25:05,880 HAVE PARTICIPATED IN 651 00:25:05,880 --> 00:25:07,840 CONGRESSIONAL BRIEFINGS WITH 652 00:25:07,840 --> 00:25:10,320 STAFF IN CONGRESS, INCLUDING 653 00:25:10,320 --> 00:25:14,040 THOSE HERE, ON A WHOLE VARIETY 654 00:25:14,040 --> 00:25:15,800 OF SUBJECTS INCLUDING MONKEYPOX, 655 00:25:15,800 --> 00:25:20,080 SUE DAN EBOLA VIRUS OUTBREAK, 656 00:25:20,080 --> 00:25:21,320 PAXLOVID REBOUND, OTHER TOPICS. 657 00:25:21,320 --> 00:25:25,840 I'M GOING TO RUN THROUGH THE 658 00:25:25,840 --> 00:25:26,640 FOLLOWING SLIDES QUICKLY. 659 00:25:26,640 --> 00:25:28,280 DEALING WITH CHANGES IN 660 00:25:28,280 --> 00:25:33,240 LEADERSHIP IN THE 118th 661 00:25:33,240 --> 00:25:33,840 CONGRESS. 662 00:25:33,840 --> 00:25:35,760 CHUCK SCHUMER IS MAJORITY LEADER 663 00:25:35,760 --> 00:25:39,800 IN THE SENATE, MITCH McCONNELL 664 00:25:39,800 --> 00:25:42,320 AS THE MINORITY LEADER. 665 00:25:42,320 --> 00:25:43,720 YOU KNOW KEVIN McCARTHY IS NOW 666 00:25:43,720 --> 00:25:47,880 SPEAKER OF THE HOUSE, AND THAT 667 00:25:47,880 --> 00:25:48,960 REPRESENTATIVE HAKEEM JEFFRIES 668 00:25:48,960 --> 00:25:51,520 HAS BECOME THE MINORITY LEADER. 669 00:25:51,520 --> 00:25:52,280 THE SENATE APPROPRIATIONS 670 00:25:52,280 --> 00:25:54,160 COMMITTEE IS NOW CHAIRED BY 671 00:25:54,160 --> 00:25:55,960 PATTY MURRAY WITH RANKING MEMBER 672 00:25:55,960 --> 00:26:00,800 BEING SUSAN COLLINS FROM MAINE. 673 00:26:00,800 --> 00:26:01,960 THE HHS EDUCATION APPROPRIATIONS 674 00:26:01,960 --> 00:26:03,320 SUBCOMMITTEE, THE CHAIR AND 675 00:26:03,320 --> 00:26:06,840 RANKING MEMBER YET TO BE 676 00:26:06,840 --> 00:26:07,160 DETERMINED. 677 00:26:07,160 --> 00:26:08,720 THE SENATE HEALTH EDUCATION 678 00:26:08,720 --> 00:26:11,000 LABOR AND PENSIONS COMMITTEE IS 679 00:26:11,000 --> 00:26:13,400 NOW CHAIRED BY SENATOR BERNIE 680 00:26:13,400 --> 00:26:16,240 SANDERS, I MET WITH HIM ALONG 681 00:26:16,240 --> 00:26:19,400 WITH LARRY TABAK JUST YESTERDAY. 682 00:26:19,400 --> 00:26:22,720 RANKING MEMBER SENATOR BILL 683 00:26:22,720 --> 00:26:25,560 CASSIDY IS THE RANKING MEMBER. 684 00:26:25,560 --> 00:26:27,840 HOMELAND SECURITY AND GOVERNMENT 685 00:26:27,840 --> 00:26:29,800 AFFAIRS COMMITTEE IS CHAIRED BY 686 00:26:29,800 --> 00:26:31,800 SENATOR GARY PETERS, RANKING 687 00:26:31,800 --> 00:26:35,520 MEMBER SENATOR RAND PAUL. 688 00:26:35,520 --> 00:26:36,400 HOUSE APPROPRIATIONS COMMITTEE 689 00:26:36,400 --> 00:26:39,560 NOW CHAIRED BY KAY GRANGER, 690 00:26:39,560 --> 00:26:43,400 RANKING MEMBER IS ROSA DELAURO, 691 00:26:43,400 --> 00:26:45,480 AND HHS APPROPRIATION 692 00:26:45,480 --> 00:26:49,840 SUBCOMMITTEE IS CHAIRED BY 693 00:26:49,840 --> 00:26:51,720 REPRESENTATIVE ROBERT ADERHOLD, 694 00:26:51,720 --> 00:26:54,200 RANKING MEMBER ROSA DELAURO. 695 00:26:54,200 --> 00:26:55,760 HOUSE ENERGY AND COMMERCE 696 00:26:55,760 --> 00:26:57,760 COMMITTEE CHAIR CATHY McMORRIS 697 00:26:57,760 --> 00:27:00,920 RODGERS, RANKING MEMBER 698 00:27:00,920 --> 00:27:02,960 REPRESENTATIVE FRANK PALLONE, 699 00:27:02,960 --> 00:27:06,400 HEALTH SUBCOMMITTEE 700 00:27:06,400 --> 00:27:07,920 REPRESENTATIVE BRETT GUTHRIE, 701 00:27:07,920 --> 00:27:10,000 RANKING MEMBER ANNA ESHOO. 702 00:27:10,000 --> 00:27:10,880 OVERSIGHT AND INVESTIGATES 703 00:27:10,880 --> 00:27:12,440 COMMITTEE CHAIR REPRESENTATIVE 704 00:27:12,440 --> 00:27:13,800 MORGAN GRIFFITH, RANKING MAYBE 705 00:27:13,800 --> 00:27:14,240 TO BE DETERMINED. 706 00:27:14,240 --> 00:27:16,960 I THINK THIS IS THE LAST OF THEM 707 00:27:16,960 --> 00:27:20,160 IS THE HOUSE OVERSIGHT AND 708 00:27:20,160 --> 00:27:21,120 ACCOUNTABILITY COMMITTEE, CHAIR 709 00:27:21,120 --> 00:27:23,000 BEING REPRESENTATIVE JAMES 710 00:27:23,000 --> 00:27:26,400 COMER, RANKING MEMBER 711 00:27:26,400 --> 00:27:32,160 REPRESENTATIVE JAMIE RASKIN AND 712 00:27:32,160 --> 00:27:35,800 SELECT COMMITTEE ON CORONAVIRUS 713 00:27:35,800 --> 00:27:37,200 PANDEMIC, CHAIRED BRAD WENSTRUP, 714 00:27:37,200 --> 00:27:38,800 RANKING MEMBER TO BE DETERMINED. 715 00:27:38,800 --> 00:27:40,720 WE'LL BE WATCHING THIS CLOSELY. 716 00:27:40,720 --> 00:27:43,120 WE'RE GOING TO MOVE TO COMMENTS 717 00:27:43,120 --> 00:27:46,640 ON SOME KEY SCIENTIFIC AREAS OF 718 00:27:46,640 --> 00:27:50,040 THE PAST FOUR MONTHS. 719 00:27:50,040 --> 00:27:51,280 GREG ORIGINALLY GAVE ME ON THE 720 00:27:51,280 --> 00:27:56,280 ORDER OF 50 SLIDES, IN THE 721 00:27:56,280 --> 00:28:01,400 INTEREST OF TIME WE CUT THAT 722 00:28:01,400 --> 00:28:02,080 BACK TOUCHING ON MAJOR 723 00:28:02,080 --> 00:28:02,840 HIGHLIGHTS IN THE PAST YEAR. 724 00:28:02,840 --> 00:28:05,920 THIS IS A LIST OF SOME DISEASES 725 00:28:05,920 --> 00:28:07,640 THAT HAD OUTBREAKS DURING 2022, 726 00:28:07,640 --> 00:28:09,320 EITHER IN THE UNITED STATES OR 727 00:28:09,320 --> 00:28:11,400 MANY COUNTRIES OR OUTSIDE OF THE 728 00:28:11,400 --> 00:28:13,200 UNITED STATES, AND YOU'RE 729 00:28:13,200 --> 00:28:16,120 FAMILIAR WITH THE FREQUENCY OF 730 00:28:16,120 --> 00:28:18,400 THESE OUTBREAKS. 731 00:28:18,400 --> 00:28:21,640 LET ME BRIEFLY SUMMARIZE 3+ 732 00:28:21,640 --> 00:28:23,280 YEARS OF RESEARCH ON COVID-19, A 733 00:28:23,280 --> 00:28:26,120 SLIDE OF THE NUMBER OF NEW CASES 734 00:28:26,120 --> 00:28:28,080 WHICH NOBODY TAKES QUITE 735 00:28:28,080 --> 00:28:28,880 SERIOUSLY AT THIS POINT BECAUSE 736 00:28:28,880 --> 00:28:30,640 SO MANY OF THE CASES ARE 737 00:28:30,640 --> 00:28:33,240 DIAGNOSED AT HOME AND NEVER 738 00:28:33,240 --> 00:28:33,520 REPORTED. 739 00:28:33,520 --> 00:28:35,760 MUCH MORE IMPORTANT IS THE 740 00:28:35,760 --> 00:28:36,480 HOSPITALIZATIONS WHICH WE 741 00:28:36,480 --> 00:28:38,280 BELIEVE IS MUCH MORE ACCURATE 742 00:28:38,280 --> 00:28:38,520 NUMBER. 743 00:28:38,520 --> 00:28:42,560 WHEN I TOOK OVER AS ACTING 744 00:28:42,560 --> 00:28:45,800 DIRECTOR HERE, ON JANUARY 1, MY 745 00:28:45,800 --> 00:28:48,280 NIGHTMARE FOR SEVERAL WEEKS WAS 746 00:28:48,280 --> 00:28:51,000 THAT THIS CURVE WOULD BE HERE AS 747 00:28:51,000 --> 00:28:52,200 OF COUNCIL. 748 00:28:52,200 --> 00:28:53,840 AS YOU CAN SEE, THAT HAS NOT 749 00:28:53,840 --> 00:28:58,200 TURNED OUT TO BE THE CASE, AND 750 00:28:58,200 --> 00:28:59,080 THE NUMBERS OF HOSPITALIZATIONS 751 00:28:59,080 --> 00:29:01,080 HAVE BEEN FALLING OVER THE LAST 752 00:29:01,080 --> 00:29:01,720 SEVERAL WEEKS. 753 00:29:01,720 --> 00:29:03,480 IT HAS ENABLED ME TO FINALLY 754 00:29:03,480 --> 00:29:04,920 BEGIN TO EXHALE AGAIN AS IT 755 00:29:04,920 --> 00:29:08,400 SEEMS THAT DESPITE THE FACT THE 756 00:29:08,400 --> 00:29:11,360 COUNTRY HAS LARGELY OPENED TO 757 00:29:11,360 --> 00:29:12,360 BUSINESS, ORDINARY KIND OF WAYS, 758 00:29:12,360 --> 00:29:15,000 WE'RE 759 00:29:15,000 --> 00:29:17,560 WE'RE NOT HAVING THE KIND OF 760 00:29:17,560 --> 00:29:18,960 RESURGENCE WE FEARED MIGHT 761 00:29:18,960 --> 00:29:19,960 OCCUR. 762 00:29:19,960 --> 00:29:22,680 YOU DO KNOW XBB.1.5 IS THE MOST 763 00:29:22,680 --> 00:29:25,000 RECENT VARIANT NOW OVER 50% OF 764 00:29:25,000 --> 00:29:28,760 CASES IN THIS COUNTRY. 765 00:29:28,760 --> 00:29:29,360 BUT, AGAIN, WITHOUT 766 00:29:29,360 --> 00:29:30,680 HOSPITALIZATIONS INCREASING THIS 767 00:29:30,680 --> 00:29:33,880 IS NOT PROVING TO BE A MAJOR 768 00:29:33,880 --> 00:29:36,600 CONCERN AT THIS POINT. 769 00:29:36,600 --> 00:29:37,240 YOU'RE AWARE THERAPEUTICS HAVE 770 00:29:37,240 --> 00:29:40,320 BEEN DEVELOPED OVER THE COURSE 771 00:29:40,320 --> 00:29:44,600 OF THE YEARS, PARTICULARLY 772 00:29:44,600 --> 00:29:47,160 PAXLOVID, REMDESIVIR AND MAL 773 00:29:47,160 --> 00:29:50,080 KNOW PEER VEER, AND WE'VE BEEN 774 00:29:50,080 --> 00:29:53,240 INVOLVED IN STUDIES OF IMMUNE 775 00:29:53,240 --> 00:29:53,920 MODULATORS, HEPARIN FOR 776 00:29:53,920 --> 00:29:54,800 HOSPITALIZED PATIENTS. 777 00:29:54,800 --> 00:30:01,040 THAT LEADS ME TO MENTION THE NIH 778 00:30:01,040 --> 00:30:01,800 COVID-19 TREATMENT GUIDELINES, 779 00:30:01,800 --> 00:30:04,080 PANEL TO DEVELOP TREATMENT 780 00:30:04,080 --> 00:30:06,640 GUIDELINES WAS ORGANIZED ALMOST 781 00:30:06,640 --> 00:30:11,840 IMMEDIATELY MARCH 24, 2020, 782 00:30:11,840 --> 00:30:14,040 UNDER CO-DIRECTION OF CLIFF 783 00:30:14,040 --> 00:30:16,000 LANE, UPDATED 62 TIMES, 784 00:30:16,000 --> 00:30:18,360 ESSENTIALLY IN REAL TIME WITH AS 785 00:30:18,360 --> 00:30:22,560 MANY AS 45 MILLION PAGE VIEWS. 786 00:30:22,560 --> 00:30:24,760 YOU KNOW THERE ARE NOW FOUR 787 00:30:24,760 --> 00:30:27,160 VACCINES AVAILABLE IN THE UNITED 788 00:30:27,160 --> 00:30:31,080 STATES, TWO mRNA VACCINES, ONE 789 00:30:31,080 --> 00:30:32,120 FROM PFIZER BioNTech, THE 790 00:30:32,120 --> 00:30:33,720 OVER FROM MODERNA. 791 00:30:33,720 --> 00:30:37,880 NOVAVAX HAS A PROTEIN SUBUNIT 792 00:30:37,880 --> 00:30:41,160 VACCINE, J&J JANSSEN HAS A VIRAL 793 00:30:41,160 --> 00:30:42,840 VECTOR VACCINE THAT CAN BE GIVEN 794 00:30:42,840 --> 00:30:46,200 IN SOME SITUATIONS. 795 00:30:46,200 --> 00:30:47,440 YOU KNOW CDC RECOMMENDED WE 796 00:30:47,440 --> 00:30:51,360 CHANGE TO A BOOSTER THAT'S A 797 00:30:51,360 --> 00:30:54,640 BIVALENT BOOSTER INCLUDING THE 798 00:30:54,640 --> 00:30:55,640 ORIGINAL WUHAN STRAIN BUT 799 00:30:55,640 --> 00:30:58,680 INCLUDING HALF THE VACCINE BEING 800 00:30:58,680 --> 00:31:02,760 THE MOST RECENT OMICRON VARIANTS 801 00:31:02,760 --> 00:31:04,080 PRIOR TO XBB.1.5. 802 00:31:04,080 --> 00:31:05,960 IF YOU DON'T THINK VACCINATION 803 00:31:05,960 --> 00:31:09,120 MATTERS OR BOOSTERS MATTER, LOOK 804 00:31:09,120 --> 00:31:13,480 AT THIS AGE ADJUSTED RATE FOR 805 00:31:13,480 --> 00:31:14,360 COVID-19 HOSPITALIZATION. 806 00:31:14,360 --> 00:31:18,200 UNVACCINATED, VACCINATED WITH NO 807 00:31:18,200 --> 00:31:20,200 BOOSTER, UPDATED BOOSTER WITH 808 00:31:20,200 --> 00:31:22,600 THE BIVALENT, AND THOSE ARE THE 809 00:31:22,600 --> 00:31:23,480 DIFFERENT IN HOSPITALIZATIONS 810 00:31:23,480 --> 00:31:23,960 RATES. 811 00:31:23,960 --> 00:31:26,200 IF YOU DON'T THINK VACCINATION 812 00:31:26,200 --> 00:31:33,240 MATTERS, LOOK AT THIS SLIDE. 813 00:31:33,240 --> 00:31:35,000 THERE HAVE BEEN THREE OUTBREAKS 814 00:31:35,000 --> 00:31:39,040 IN THREE YEARS, SARS, MERS, 815 00:31:39,040 --> 00:31:39,600 COVID-19. 816 00:31:39,600 --> 00:31:41,240 WE'VE ALSO SEEN THE RAPID 817 00:31:41,240 --> 00:31:43,000 DEVELOPMENT OF VARIANTS OF 818 00:31:43,000 --> 00:31:45,160 CONCERN OVER THE PAST THREE 819 00:31:45,160 --> 00:31:47,880 YEARS, SO CLEARLY THERE NEED TO 820 00:31:47,880 --> 00:31:49,680 BE INNOVATIVE APPROACHES TO 821 00:31:49,680 --> 00:31:51,400 INDUCE BROAD DURABLE PROTECTION 822 00:31:51,400 --> 00:31:52,320 AGAINST CORONAVIRUSES. 823 00:31:52,320 --> 00:31:54,600 NOT ONLY THOSE WE KNOW BUT THOSE 824 00:31:54,600 --> 00:31:55,680 WE DON'T KNOW YET. 825 00:31:55,680 --> 00:31:59,120 WHICH LEADS TO OUR EFFORT TO 826 00:31:59,120 --> 00:32:01,160 DEVELOP NEXT GENERATION 827 00:32:01,160 --> 00:32:01,400 VACCINES. 828 00:32:01,400 --> 00:32:05,200 OUR FIRST MAIN EFFORT IS TO 829 00:32:05,200 --> 00:32:08,160 DEVELOP A PAN CORONAVIRUS 830 00:32:08,160 --> 00:32:08,400 VACCINE. 831 00:32:08,400 --> 00:32:11,120 AND IN 2021, WE ACTUALLY WENT 832 00:32:11,120 --> 00:32:14,840 AHEAD AND AWARDED SEVEN AWARDS 833 00:32:14,840 --> 00:32:18,040 TO CENTERS TO DEVELOP A 834 00:32:18,040 --> 00:32:20,240 PAN-CORONAVIRUS VACCINE, AT 835 00:32:20,240 --> 00:32:21,880 LEAST ONE CENTER WE EXPECT TO 836 00:32:21,880 --> 00:32:23,840 BEGIN CLINICAL TRIALS IN THE 837 00:32:23,840 --> 00:32:27,440 VERY NEAR FUTURE. 838 00:32:27,440 --> 00:32:31,280 THE OTHER AREA OF THERE IS 839 00:32:31,280 --> 00:32:33,240 MUCOSAL VACCINE WITH AIM OF 840 00:32:33,240 --> 00:32:34,360 PREVENTING INFECTION, NOT JUST 841 00:32:34,360 --> 00:32:35,840 SEVERE DISEASE SO WE CAN BLOCK 842 00:32:35,840 --> 00:32:40,120 TRANSMISSION OF THE VIRUS THAT 843 00:32:40,120 --> 00:32:41,320 SEEMS SO TRANSMISSIBLE. 844 00:32:41,320 --> 00:32:45,040 THIS IS NOT NECESSARILY GOING TO 845 00:32:45,040 --> 00:32:46,560 BE AS EASY TO PURSUE AS SOME 846 00:32:46,560 --> 00:32:48,360 PEOPLE THINK. 847 00:32:48,360 --> 00:32:51,200 THERE ARE TWO RECENT ARTICLES ON 848 00:32:51,200 --> 00:32:54,480 THE SUBJECT OF RETHINKING NEXT 849 00:32:54,480 --> 00:32:58,160 GENERATION VACCINES IN 850 00:32:58,160 --> 00:33:08,880 PARTICULAR MUCOSAL VACCINES ONE 851 00:33:08,880 --> 00:33:11,640 BY DR. MORENS, HIGHLIGHTING 852 00:33:11,640 --> 00:33:15,480 DIFFICULTIES IN PRODUCING A 853 00:33:15,480 --> 00:33:18,320 TRANSMISSION-BLOCKING MUCOSAL 854 00:33:18,320 --> 00:33:19,040 VACCINE. 855 00:33:19,040 --> 00:33:25,760 WE DID ORGANIZE BACK IN 2022, 856 00:33:25,760 --> 00:33:28,080 NOVEMBER, A WORKSHOP ON THE 857 00:33:28,080 --> 00:33:29,680 DEVELOPMENT OF MUCOSAL VACCINES, 858 00:33:29,680 --> 00:33:33,240 WE DID THIS AFTER THINKING OF -- 859 00:33:33,240 --> 00:33:37,200 PROCEEDING WITH IT, WE JOINED BY 860 00:33:37,200 --> 00:33:43,160 PARTNERS BARDA, CEPI, BILL AND 861 00:33:43,160 --> 00:33:45,800 MELINDA GATES FOUNDATION AND 862 00:33:45,800 --> 00:33:47,880 WELLCOME TRUST, ALL THE ISSUES 863 00:33:47,880 --> 00:33:54,320 WITH MUCOSAL VACCINES WERE AIRED 864 00:33:54,320 --> 00:33:55,560 AND CONSIDERED. 865 00:33:55,560 --> 00:33:57,280 THE LATE DRAFT IS CIRCULATING AT 866 00:33:57,280 --> 00:33:58,400 THIS MOMENT AND I HOPE IT WILL 867 00:33:58,400 --> 00:34:02,840 BE PUBLISHED IN THE NEAR FOR -- 868 00:34:02,840 --> 00:34:05,040 NEAR FUTURE. 869 00:34:05,040 --> 00:34:06,120 THERE ARE CANDIDATE MUCOSAL 870 00:34:06,120 --> 00:34:07,480 VACCINES MOVING TO CLINICAL 871 00:34:07,480 --> 00:34:11,520 TRIALS, ALL SUPPORTED IN PART BY 872 00:34:11,520 --> 00:34:13,160 NIAID, THIS ONE FROM ST. LOUIS, 873 00:34:13,160 --> 00:34:16,360 THIS ONE FROM OUR OWN INTRAMURAL 874 00:34:16,360 --> 00:34:16,760 PROGRAM. 875 00:34:16,760 --> 00:34:21,480 BUT WE HAVE WORKED HARD TO 876 00:34:21,480 --> 00:34:23,320 STRESS TO THE FUNDING AGENCIES 877 00:34:23,320 --> 00:34:25,240 DOWNTOWN THAT THIS IS NOT GOING 878 00:34:25,240 --> 00:34:27,440 TO BE A REPEAT OF OPERATION WARP 879 00:34:27,440 --> 00:34:30,480 SPEED WHERE WE HAVE SUCCESS IN 880 00:34:30,480 --> 00:34:33,760 LESS THAN ONE-YEAR TIME. 881 00:34:33,760 --> 00:34:36,120 THIS IS A LONGER--TERM EFFORT 882 00:34:36,120 --> 00:34:36,880 WE'RE UNDERTAKING. 883 00:34:36,880 --> 00:34:39,320 LET ME TOUCH BRIEFLY ON HIV/AIDS 884 00:34:39,320 --> 00:34:42,520 AS WE ALWAYS DO. 885 00:34:42,520 --> 00:34:45,760 THIS REMAINS A TERRIBLE PROBLEM 886 00:34:45,760 --> 00:34:47,440 WORLDWIDE, WITH 38 MILLION 887 00:34:47,440 --> 00:34:51,680 PEOPLE LIVING WITH HIV AT THIS 888 00:34:51,680 --> 00:34:53,560 TIME. 889 00:34:53,560 --> 00:34:56,200 MAJOR NEWS IN THIS AREA 890 00:34:56,200 --> 00:34:58,480 UNFORTUNATELY IS THE FAILURE OF 891 00:34:58,480 --> 00:35:03,240 THE PHASE 3 SO CALLED MOSAIC 892 00:35:03,240 --> 00:35:08,120 TRIAL OF HIV VACCINE REGIMEN IN 893 00:35:08,120 --> 00:35:11,960 4,000 MEN IN EUROPE, NORTH 894 00:35:11,960 --> 00:35:13,720 AMERICA, SOUTH AFRICA. 895 00:35:13,720 --> 00:35:15,680 EVEN MORE DISAPPOINTING THAN THE 896 00:35:15,680 --> 00:35:18,320 FAILURE AND COMPLETE FAILURE OF 897 00:35:18,320 --> 00:35:20,960 THIS VACCINE WAS THE FACT THAT 898 00:35:20,960 --> 00:35:23,480 BOTH TREATMENT ARMS AND PLACEBO 899 00:35:23,480 --> 00:35:26,320 ARM HAVE INCIDENCE OF HIV OF 4%, 900 00:35:26,320 --> 00:35:27,680 DESPITE THE FACT THAT PrEP WAS 901 00:35:27,680 --> 00:35:29,600 OFFERED TO ALL OF THE 902 00:35:29,600 --> 00:35:30,840 PARTICIPANTS IN THIS TRIAL. 903 00:35:30,840 --> 00:35:33,040 WE THINK WE KNOW HOW TO PREVENT 904 00:35:33,040 --> 00:35:34,320 HIV INFECTION BUT WE CERTAINLY 905 00:35:34,320 --> 00:35:36,640 DON'T KNOW HOW TO PREVENT IT IN 906 00:35:36,640 --> 00:35:37,840 THE REAL WORLD. 907 00:35:37,840 --> 00:35:39,480 LET'S TALK BRIEFLY ABOUT THE 908 00:35:39,480 --> 00:35:40,680 GLOBAL BURDEN OF MALARIA WHICH 909 00:35:40,680 --> 00:35:42,880 CONTINUES TO BE A MAJOR PROBLEM 910 00:35:42,880 --> 00:35:44,080 FOR CHILDREN, PARTICULARLY THOSE 911 00:35:44,080 --> 00:35:47,560 UNDER 5 YEARS OF AGE, WITH 912 00:35:47,560 --> 00:35:51,160 SUBSTANTIAL NUMBER OF WORLDWIDE 913 00:35:51,160 --> 00:35:51,840 DEATHS. 914 00:35:51,840 --> 00:35:55,560 WE'RE VERY PROUD OF THE 915 00:35:55,560 --> 00:35:56,240 ANNOUNCEMENT OF SAFETY AND 916 00:35:56,240 --> 00:35:57,400 EFFICACY OF A MONOCLONAL 917 00:35:57,400 --> 00:36:00,240 ANTIBODY DEVELOPED IN PART IN 918 00:36:00,240 --> 00:36:08,680 OUR INTRAMURAL PART BY BOB CDER 919 00:36:08,680 --> 00:36:14,240 AND BILL COMPTON IN PROTECTING 920 00:36:14,240 --> 00:36:15,240 HEALTHY NON-PREGNANT ADULTS 921 00:36:15,240 --> 00:36:18,760 DURING AN INTENTION SIX MONTHS, 922 00:36:18,760 --> 00:36:24,560 EFFICACY WAS 88% OVER A 24-WEEK 923 00:36:24,560 --> 00:36:24,920 PERIOD. 924 00:36:24,920 --> 00:36:25,760 TRIALS IN CHILDREN AND OTHER 925 00:36:25,760 --> 00:36:27,600 PARTS OF AFRICA WITH BEING 926 00:36:27,600 --> 00:36:29,120 INITIATED, I THINK YOU'LL HEAR 927 00:36:29,120 --> 00:36:30,880 MORE ABOUT THE MONOCLONAL 928 00:36:30,880 --> 00:36:32,600 ANTIBODIES TO PREVENT MALARIA 929 00:36:32,600 --> 00:36:35,040 INFECTION IN THE COMING YEARS. 930 00:36:35,040 --> 00:36:36,600 THEN OF COURSE THERE IS EBOLA, 931 00:36:36,600 --> 00:36:41,160 OVER THE YEARS AS YOU KNOW THERE 932 00:36:41,160 --> 00:36:47,280 HAVE BEEN OUTBREAKS OF ZAIRE, 933 00:36:47,280 --> 00:36:48,680 SUDAN AND MARBURG CLOSELY 934 00:36:48,680 --> 00:36:55,080 RELATED VIRUS, THIS YEAR 935 00:36:55,080 --> 00:36:58,440 ATTENTION ON THE DEMOCRATIC 936 00:36:58,440 --> 00:37:01,760 REPUBLIC OF CONGO WITH OUTBREAK 937 00:37:01,760 --> 00:37:03,080 OF ZAIRE EBOLA VIRUS. 938 00:37:03,080 --> 00:37:04,720 THE GOOD NEWS RECENTLY UGANDA 939 00:37:04,720 --> 00:37:07,640 WAS ABLE TO DECLARE THE END OF 940 00:37:07,640 --> 00:37:09,640 THIS EBOLA DISEASE OUTBREAK. 941 00:37:09,640 --> 00:37:12,840 LET ME JUST BRIEFLY SAY THAT 942 00:37:12,840 --> 00:37:16,000 THIS IS ONE EXAMPLE OF A TRIAL 943 00:37:16,000 --> 00:37:18,840 UNDERWAY, TESTING IN THIS CASE 944 00:37:18,840 --> 00:37:20,480 OF MARBURG VACCINE, SHOWING 945 00:37:20,480 --> 00:37:23,440 PROMISE IN THE CLINICAL TRIAL 946 00:37:23,440 --> 00:37:27,440 BUT IN FACT NIH NIAID SCIENTISTS 947 00:37:27,440 --> 00:37:31,120 ARE WORKING ON ADDITIONAL ZAIRE 948 00:37:31,120 --> 00:37:32,640 EBOLA VACCINES, SUDAN EBOLA 949 00:37:32,640 --> 00:37:37,360 VACCINES, AS WELL AS MARBURG 950 00:37:37,360 --> 00:37:38,080 VACCINES. 951 00:37:38,080 --> 00:37:38,800 AGAIN TO MENTION UNIVERSAL FLU 952 00:37:38,800 --> 00:37:41,160 AS A HIGH PRIORITY FOR THE 953 00:37:41,160 --> 00:37:43,480 INSTITUTE, THIS IS ONE EXAMPLE 954 00:37:43,480 --> 00:37:46,320 RECENTLY IN NOVEMBER OF A 955 00:37:46,320 --> 00:37:48,240 PUBLICATION OF A PROMISING 956 00:37:48,240 --> 00:37:50,560 mRNA VACCINE AGAINST ALL THE 957 00:37:50,560 --> 00:37:52,000 KNOWN INFLUENZA VIRUS SUBTYPES, 958 00:37:52,000 --> 00:37:55,080 WE HAVE MULTIPLE CANDIDATES IN 959 00:37:55,080 --> 00:37:57,800 OUR INTRAMURAL PROGRAM FOR THE 960 00:37:57,800 --> 00:38:02,160 UNIVERSAL FLU VACCINES, YOU WILL 961 00:38:02,160 --> 00:38:03,760 SEE MANY CLINICAL PROGRAMS TO 962 00:38:03,760 --> 00:38:06,360 TEST THESE VACCINES OVER THE 963 00:38:06,360 --> 00:38:07,360 NEXT SEVERAL YEARS. 964 00:38:07,360 --> 00:38:10,160 LET ME TURN A LITTLE BIT TO 965 00:38:10,160 --> 00:38:10,680 IMMUNOLOGY. 966 00:38:10,680 --> 00:38:12,240 THIS IS A STUDY PUBLISHED IN 967 00:38:12,240 --> 00:38:15,760 "THE LANCET" THAT WAS THE FIRST 968 00:38:15,760 --> 00:38:17,600 TO DEMONSTRATE AIR CONTAMINANTS, 969 00:38:17,600 --> 00:38:19,680 OZONE AND FINE PARTICULATES, 970 00:38:19,680 --> 00:38:22,000 INDEPENDENT OF ALLERGEN AND 971 00:38:22,000 --> 00:38:28,120 RESPIRATORY VIRAL EXPOSURES CAN 972 00:38:28,120 --> 00:38:29,320 TRIGGER ASTHMA EXACERBATIONS IN 973 00:38:29,320 --> 00:38:38,640 CHILDREN, A STUDY FROM JEFF 974 00:38:38,640 --> 00:38:41,240 COHEN'S GROUP, MONOCLONAL 975 00:38:41,240 --> 00:38:43,000 ANTIBODIES PROVIDING PROTECTION 976 00:38:43,000 --> 00:38:45,760 AGAINST EBV, WE'LL HEAR MORE IN 977 00:38:45,760 --> 00:38:47,400 COMING YEARS, AND SYSTEMS 978 00:38:47,400 --> 00:38:48,960 BIOLOGY APPROACH TO DETERMINING 979 00:38:48,960 --> 00:38:50,880 DETERMINANTS OF IMMUNE RESPONSES 980 00:38:50,880 --> 00:38:52,920 TO VACCINES, NOT A VACCINE BUT 981 00:38:52,920 --> 00:38:54,840 VACCINES IN GENERAL, THIS WAS A 982 00:38:54,840 --> 00:38:57,480 PROGRAM THAT STUDIED RESPONSE TO 983 00:38:57,480 --> 00:39:04,480 13 VACCINES IN THE HUMAN 984 00:39:04,480 --> 00:39:06,760 IMMUNOLOGY PROJECT CONSORTIUM, 985 00:39:06,760 --> 00:39:09,080 HIPC, FUNDED BY IMMUNOLOGY, 986 00:39:09,080 --> 00:39:10,120 ALLERGY AND TRANSPLANTATION, 987 00:39:10,120 --> 00:39:14,400 IDENTIFYING A PATTERN OF 988 00:39:14,400 --> 00:39:15,600 TRANSCRIPTIONAL RESPONSE THAT 989 00:39:15,600 --> 00:39:17,840 CHARACTERIZES THOSE WHO RESPOND 990 00:39:17,840 --> 00:39:18,480 WELL TO VACCINATION. 991 00:39:18,480 --> 00:39:21,760 LET ME STOP THERE AND OPEN THIS 992 00:39:21,760 --> 00:39:27,440 FOR QUESTIONS. 993 00:39:27,440 --> 00:39:29,240 I APPRECIATE YOUR ATTENTION. 994 00:39:29,240 --> 00:39:31,520 I'M HERE TO TAKE QUESTIONS LIVE. 995 00:39:31,520 --> 00:39:34,840 THERE WERE TWO OR THREE PLACES I 996 00:39:34,840 --> 00:39:37,000 CRINGED AS A MISSTATEMENT BUT 997 00:39:37,000 --> 00:39:38,520 YOU PROBABLY PICKED UP THE 998 00:39:38,520 --> 00:39:39,520 ERRORS IN THE PRE-RECORDED 999 00:39:39,520 --> 00:39:40,400 REMARKS. 1000 00:39:40,400 --> 00:39:41,720 IF YOU HAVE QUESTIONS, SING OUT. 1001 00:39:41,720 --> 00:39:44,200 I DON'T SEE YOU ALL AND I WOULD 1002 00:39:44,200 --> 00:39:46,560 BE HAPPY TO TAKE QUESTIONS FROM 1003 00:39:46,560 --> 00:39:49,080 MANY OF YOU. 1004 00:39:49,080 --> 00:39:49,360 MONICA, HI. 1005 00:39:49,360 --> 00:39:50,680 >>THANK YOU SO MUCH. 1006 00:39:50,680 --> 00:39:54,000 THAT WAS GREAT. 1007 00:39:54,000 --> 00:39:55,760 DESPITE THE CONGRESSIONAL 1008 00:39:55,760 --> 00:39:58,120 MISUNDERSTANDING WHY WE SHOULD 1009 00:39:58,120 --> 00:39:59,120 FUND PANDEMIC PREPAREDNESS 1010 00:39:59,120 --> 00:40:02,840 INITIATIVE HOPEFULLY WE CAN 1011 00:40:02,840 --> 00:40:04,600 CONVINCE THEM HOW IMPORTANT IT 1012 00:40:04,600 --> 00:40:04,800 IS. 1013 00:40:04,800 --> 00:40:10,840 ONE QUESTION IS, MOSAICO TRIALS 1014 00:40:10,840 --> 00:40:13,760 WERE DISAPPOINTED BUT NOT 1015 00:40:13,760 --> 00:40:16,720 UNEXPECTS, THE VACCINES ARE 1016 00:40:16,720 --> 00:40:18,720 EXCITING, WONDERING -- THOSE ARE 1017 00:40:18,720 --> 00:40:23,560 NIH FUNDED, SMALL CLINICAL 1018 00:40:23,560 --> 00:40:25,000 TRIALS IN HUMANS, WONDERING IF 1019 00:40:25,000 --> 00:40:25,960 THERE WILL BE INTERIM RESULTS 1020 00:40:25,960 --> 00:40:27,240 PUT OUT ABOUT THOSE. 1021 00:40:27,240 --> 00:40:31,840 NUMBER TWO, I WANT TO ASK ABOUT 1022 00:40:31,840 --> 00:40:33,200 COVID VACCINES, SPECIFICALLY THE 1023 00:40:33,200 --> 00:40:36,480 INDIAN COMPANY THAT DOES HAVE A 1024 00:40:36,480 --> 00:40:38,880 MUCOSAL VACCINE WHICH IT'S VERY 1025 00:40:38,880 --> 00:40:41,640 UNCLEAR TO ME SORT OF THE 1026 00:40:41,640 --> 00:40:42,360 POST-MARKETING SURVEILLANCE AND 1027 00:40:42,360 --> 00:40:43,600 WHAT'S GOING TO HAPPEN WITH THAT 1028 00:40:43,600 --> 00:40:46,120 BUT THEY DID PUT THAT OUT. 1029 00:40:46,120 --> 00:40:48,160 AND WONDERING IF THE NIH HAS 1030 00:40:48,160 --> 00:40:49,360 EVALUATED THAT PRODUCT AND THE 1031 00:40:49,360 --> 00:40:50,920 SAME WITH THEIR WHOLE VIRUS 1032 00:40:50,920 --> 00:40:53,560 VACCINE WHICH IS THE COVAX 1033 00:40:53,560 --> 00:40:55,560 VACCINE WHICH IS DEVELOPED WITH 1034 00:40:55,560 --> 00:40:57,520 ADJUVANT FUNDED BY THE NIH, LIKE 1035 00:40:57,520 --> 00:40:59,480 THE ADJUVANT WAS FROM THE NIH, 1036 00:40:59,480 --> 00:41:04,960 THOSE TWO QUESTIONS ON VACCINES, 1037 00:41:04,960 --> 00:41:05,440 HIV AND COVID. 1038 00:41:05,440 --> 00:41:06,640 >>CARL, ARE YOU ON? 1039 00:41:06,640 --> 00:41:08,800 >>I'LL ANSWER THE FIRST 1040 00:41:08,800 --> 00:41:09,240 QUESTION. 1041 00:41:09,240 --> 00:41:11,280 YES, MONICA, WE'RE CONDUCTING 1042 00:41:11,280 --> 00:41:13,800 STUDIES OF DIFFERENT IMMUNOGENS 1043 00:41:13,800 --> 00:41:16,320 USING THE MESSENGER RNA 1044 00:41:16,320 --> 00:41:17,640 PLATFORM, EVALUATING SAFETY BUT 1045 00:41:17,640 --> 00:41:21,160 ALSO ARE USING SOME NOVEL ASSAYS 1046 00:41:21,160 --> 00:41:23,760 TO EXAMINE WHERE THE ANTIBODIES 1047 00:41:23,760 --> 00:41:26,320 THAT GET INDUCED IN PEOPLE BIND 1048 00:41:26,320 --> 00:41:28,480 TO THE HIV ENVELOPE. 1049 00:41:28,480 --> 00:41:31,000 SO THOSE WILL BE DEVELOPED AND 1050 00:41:31,000 --> 00:41:31,240 RELEASED. 1051 00:41:31,240 --> 00:41:35,040 THE INTENT FOR US IS TO REALLY 1052 00:41:35,040 --> 00:41:38,000 MOVE INTO A SET OF EXPERIMENTAL 1053 00:41:38,000 --> 00:41:40,640 MEDICINE TRIALS TO RAPIDLY 1054 00:41:40,640 --> 00:41:41,480 EVALUATE AND ITERATE OUR 1055 00:41:41,480 --> 00:41:43,360 IMMUNOGEN DESIGN SO WE CAN 1056 00:41:43,360 --> 00:41:46,520 ACCELERATE THE PROCESS OF 1057 00:41:46,520 --> 00:41:46,800 DISCOVERY. 1058 00:41:46,800 --> 00:41:47,040 >>OKAY. 1059 00:41:47,040 --> 00:41:47,640 THANK YOU. 1060 00:41:47,640 --> 00:41:50,360 >>ON THE ISSUE OF THE MUCOSAL 1061 00:41:50,360 --> 00:41:52,240 VACCINES, THE INDIANS ARE MOVING 1062 00:41:52,240 --> 00:41:54,160 AHEAD I BELIEVE WITH THE MICHAEL 1063 00:41:54,160 --> 00:41:54,520 DIAMOND PRODUCT. 1064 00:41:54,520 --> 00:41:59,760 I'VE SEEN ANIMAL DATA WITH THAT 1065 00:41:59,760 --> 00:42:01,080 PRODUCT BUT I'VE NOT SEEN HUMAN 1066 00:42:01,080 --> 00:42:01,280 DATA. 1067 00:42:01,280 --> 00:42:03,080 EMILY, DO YOU WANT TO MAKE 1068 00:42:03,080 --> 00:42:03,360 COMMENTS? 1069 00:42:03,360 --> 00:42:05,360 >>I'M HERE. 1070 00:42:05,360 --> 00:42:07,880 WE DID SUPPORT THROUGH MICHAEL 1071 00:42:07,880 --> 00:42:09,320 DIAMOND'S GRANTS THE DEVELOPMENT 1072 00:42:09,320 --> 00:42:11,600 OF A PRODUCT THAT'S NOW IN 1073 00:42:11,600 --> 00:42:13,440 ADVANCED CLINICAL DEVELOPMENT IN 1074 00:42:13,440 --> 00:42:16,080 INDIA WHICH I'M GUESSING THAT'S 1075 00:42:16,080 --> 00:42:17,120 WHAT YOU'RE TALKING ABOUT. 1076 00:42:17,120 --> 00:42:17,360 >>YEAH. 1077 00:42:17,360 --> 00:42:19,240 >>IT'S HARD TO KEEP TRACK. 1078 00:42:19,240 --> 00:42:19,680 >>YEAH. 1079 00:42:19,680 --> 00:42:21,480 THEY ARE ALREADY ROLLING IT OUT 1080 00:42:21,480 --> 00:42:23,320 SO I'M CURIOUS IF YOU HELPED 1081 00:42:23,320 --> 00:42:24,320 SUPPORT IT, WHAT KIND OF 1082 00:42:24,320 --> 00:42:26,480 EVALUATION ARE YOU GOING TO 1083 00:42:26,480 --> 00:42:28,920 REQUIRE FOR PHASE 4. 1084 00:42:28,920 --> 00:42:31,640 >>YEAH, WE CAN'T REQUIRE 1085 00:42:31,640 --> 00:42:32,480 ANYTHING. 1086 00:42:32,480 --> 00:42:34,240 IT'S THE INDIAN GOVERNMENT THAT 1087 00:42:34,240 --> 00:42:36,000 SETS THE REGULATORY STANDARDS 1088 00:42:36,000 --> 00:42:39,280 FOR SAFETY DATA IN THEIR 1089 00:42:39,280 --> 00:42:39,640 COUNTRY. 1090 00:42:39,640 --> 00:42:42,000 BUT CERTAINLY WE'RE INTERESTED. 1091 00:42:42,000 --> 00:42:44,640 SO, YOU KNOW, MAYBE WE CAN 1092 00:42:44,640 --> 00:42:48,320 REPORT BACK ON ANY DATA THAT WE 1093 00:42:48,320 --> 00:42:50,200 HAVE ACCESS TO AT A SUBSEQUENT 1094 00:42:50,200 --> 00:42:51,960 COUNCIL MEETING SINCE I THINK 1095 00:42:51,960 --> 00:42:53,480 WHAT YOU'RE TALKING ABOUT IS OF 1096 00:42:53,480 --> 00:42:54,280 GREAT INTEREST TO EVERYBODY IN 1097 00:42:54,280 --> 00:42:55,880 THE U.S. GOVERNMENT. 1098 00:42:55,880 --> 00:43:00,120 AND IN THE ACADEMIC COMMUNITY. 1099 00:43:00,120 --> 00:43:04,360 >>THANK YOU. 1100 00:43:04,360 --> 00:43:13,000 >>OTHER QUESTIONS? 1101 00:43:13,000 --> 00:43:13,640 GO AHEAD. 1102 00:43:13,640 --> 00:43:14,480 >>YES, HI. 1103 00:43:14,480 --> 00:43:17,240 THANK YOU SO MUCH FOR A 1104 00:43:17,240 --> 00:43:19,440 WONDERFUL SUMMARY AND A LOT OF 1105 00:43:19,440 --> 00:43:21,240 EVOLVING CHANGES AROUND 1106 00:43:21,240 --> 00:43:22,040 LEADERSHIP CLEARLY THAT WE'LL 1107 00:43:22,040 --> 00:43:23,280 HAVE TO SEE WHAT HAPPENS. 1108 00:43:23,280 --> 00:43:26,880 I HAVE A QUESTION IN THAT 1109 00:43:26,880 --> 00:43:27,200 REGARD. 1110 00:43:27,200 --> 00:43:29,040 I THINK MAYBE TOO EARLY TO SAY 1111 00:43:29,040 --> 00:43:30,440 BUT IN THE SENSE OF THE 1112 00:43:30,440 --> 00:43:35,400 INVESTMENT IN THE CLINICAL 1113 00:43:35,400 --> 00:43:38,160 TRIALS NETWORKS, HBTN, ACTG AND 1114 00:43:38,160 --> 00:43:40,120 HPTN, DO YOU THINK THAT WILL 1115 00:43:40,120 --> 00:43:41,440 REMAIN PRESERVED OR IS THAT 1116 00:43:41,440 --> 00:43:42,440 SOMETHING THAT COULD BE 1117 00:43:42,440 --> 00:43:45,040 INFLUENCED BY THE NEW LEADERSHIP 1118 00:43:45,040 --> 00:43:48,440 AT THE LEVEL OF NIAID AND 1119 00:43:48,440 --> 00:43:49,760 PERHAPS IT'S PROVOCATIVE 1120 00:43:49,760 --> 00:43:52,040 QUESTION BUT ONE THAT CERTAINLY 1121 00:43:52,040 --> 00:43:52,800 THERE ARE RUMORS FLYING AND 1122 00:43:52,800 --> 00:43:56,320 WOULD BE INTERESTED IN YOUR 1123 00:43:56,320 --> 00:43:57,480 PERSPECTIVE, YOUR AND CARL'S. 1124 00:43:57,480 --> 00:43:59,160 >>I CAN'T SPEAK FOR THE FUTURE 1125 00:43:59,160 --> 00:44:00,480 DIRECTOR NOT KNOWING WHO THAT 1126 00:44:00,480 --> 00:44:03,000 PERSON IS BUT CAN ASSURE YOU 1127 00:44:03,000 --> 00:44:04,960 WHILE I'M HERE THE AIDS CLINICAL 1128 00:44:04,960 --> 00:44:06,800 TRIAL NETWORKS WILL REMAIN VERY 1129 00:44:06,800 --> 00:44:08,000 MUCH INTACT. 1130 00:44:08,000 --> 00:44:09,600 AS YOU KNOW PROBABLY THEY ARE 1131 00:44:09,600 --> 00:44:11,760 VITALLY IMPORTANT IN THE COVID 1132 00:44:11,760 --> 00:44:13,600 RESPONSE. 1133 00:44:13,600 --> 00:44:14,920 HAVING A WARM READY-TO-GO 1134 00:44:14,920 --> 00:44:17,760 CLINICAL TRIALS NETWORK TURNED 1135 00:44:17,760 --> 00:44:19,600 OUT TO BE ENORMOUSLY IMPORTANT. 1136 00:44:19,600 --> 00:44:20,160 CARL, OVER TO YOU. 1137 00:44:20,160 --> 00:44:21,680 >>I AGREE WITH THAT. 1138 00:44:21,680 --> 00:44:23,480 I MEAN, THE ISSUE IS WE 1139 00:44:23,480 --> 00:44:24,760 RESPONDED BOTH ON THE 1140 00:44:24,760 --> 00:44:27,480 THERAPEUTIC SIDE AND THE VACCINE 1141 00:44:27,480 --> 00:44:28,880 AND MONOCLONAL ANTIBODY SIDE. 1142 00:44:28,880 --> 00:44:31,000 WE ARE NOT FINISHED WITH HIV. 1143 00:44:31,000 --> 00:44:34,040 THERE'S A LOT WE STILL HAVE TO 1144 00:44:34,040 --> 00:44:34,200 DO. 1145 00:44:34,200 --> 00:44:36,480 YOU DON'T TAKE A SET OF GRANTS 1146 00:44:36,480 --> 00:44:38,440 THAT ARE HALFWAY THROUGH THEIR 1147 00:44:38,440 --> 00:44:39,520 7-YEAR CYCLE AND START 1148 00:44:39,520 --> 00:44:40,160 DISMANTLING THEM. 1149 00:44:40,160 --> 00:44:44,880 WHAT WE CAN DO I THINK IS HAVE A 1150 00:44:44,880 --> 00:44:46,400 PRINCIPAL DISCUSSION CLOSER TO 1151 00:44:46,400 --> 00:44:48,160 RENEWAL ABOUT SIZE, SHAPE, AND 1152 00:44:48,160 --> 00:44:48,560 DIRECTION. 1153 00:44:48,560 --> 00:44:50,760 WE DO THAT EVERY SEVEN YEARS, AS 1154 00:44:50,760 --> 00:44:52,000 YOU'RE AWARE, LAST TIME WE 1155 00:44:52,000 --> 00:44:53,960 STARTED TWO YEARS BEFORE THE 1156 00:44:53,960 --> 00:44:54,840 RECOMPETITION. 1157 00:44:54,840 --> 00:44:56,800 WE WORE EVERYBODY OUT TALKING 1158 00:44:56,800 --> 00:44:58,040 ABOUT POTENTIAL CHANGES AND 1159 00:44:58,040 --> 00:45:02,680 INTEND TO DO SOMETHING SIMILAR 1160 00:45:02,680 --> 00:45:05,360 AGAIN. 1161 00:45:05,360 --> 00:45:06,560 >>THANK YOU. 1162 00:45:06,560 --> 00:45:09,640 ONE OTHER QUESTION IF THAT'S 1163 00:45:09,640 --> 00:45:09,880 ALLOWED. 1164 00:45:09,880 --> 00:45:10,080 >>YES. 1165 00:45:10,080 --> 00:45:13,120 >>INTERESTED TO FOLLOW UP ON 1166 00:45:13,120 --> 00:45:14,960 MONICA GANDHI'S QUESTION ABOUT 1167 00:45:14,960 --> 00:45:15,960 PANDEMIC PREPAREDNESS, HAS THERE 1168 00:45:15,960 --> 00:45:18,560 BEEN DISCUSSION AROUND SORT OF 1169 00:45:18,560 --> 00:45:20,360 COLLABORATING WITH OTHER FEDERAL 1170 00:45:20,360 --> 00:45:22,760 AGENCIES TO SORT OF GO IN 1171 00:45:22,760 --> 00:45:24,160 TOGETHER TO LOBBY OUR CONGRESS 1172 00:45:24,160 --> 00:45:26,360 AND THOSE WHO ARE EMPOWERED TO 1173 00:45:26,360 --> 00:45:27,440 REALLY MAKE THESE DECISIONS, 1174 00:45:27,440 --> 00:45:29,520 GIVEN -- I MEAN IT'S JUST A 1175 00:45:29,520 --> 00:45:30,840 COMPLETE NO BRAINER, OBVIOUSLY 1176 00:45:30,840 --> 00:45:33,800 TO PEOPLE LIKE US, BUT SEEMS 1177 00:45:33,800 --> 00:45:35,240 RATHER SHOCKING THERE ISN'T AN 1178 00:45:35,240 --> 00:45:36,360 ALLOCATION, JUST INTERESTED IN 1179 00:45:36,360 --> 00:45:39,160 WHAT IS HAPPENING AT THE LEVEL 1180 00:45:39,160 --> 00:45:40,800 OF, YOU KNOW, CONSTITUENCIES AND 1181 00:45:40,800 --> 00:45:43,640 SORT OF MAKING PRESSURED -- NOT 1182 00:45:43,640 --> 00:45:46,800 PRESSURED BUT INFORMED ADVOCACY 1183 00:45:46,800 --> 00:45:47,120 ON THIS FRONT. 1184 00:45:47,120 --> 00:45:48,760 >>AGAIN, I'LL TURN IT OVER TO 1185 00:45:48,760 --> 00:45:49,200 EMILY. 1186 00:45:49,200 --> 00:45:51,760 BUT YES, WE'VE BEEN IN CONSTANT 1187 00:45:51,760 --> 00:45:54,280 CONVERSATION WITH OUR VARIOUS 1188 00:45:54,280 --> 00:45:55,560 COLLEAGUES AROUND THE FEDERAL 1189 00:45:55,560 --> 00:45:55,880 GOVERNMENT. 1190 00:45:55,880 --> 00:45:58,960 IT REALLY IS KIND OF STAGGERING 1191 00:45:58,960 --> 00:46:01,680 THAT THREE YEARS INTO THE 1192 00:46:01,680 --> 00:46:03,320 COVID-19 EXPERIENCE, WE'RE NOT 1193 00:46:03,320 --> 00:46:07,400 IN FACT FUNDING A MAJOR PANDEMIC 1194 00:46:07,400 --> 00:46:08,040 PREPAREDNESS PROGRAM. 1195 00:46:08,040 --> 00:46:08,240 EMILY? 1196 00:46:08,240 --> 00:46:17,200 >>SO YOU'RE ASKING ABOUT OUR 1197 00:46:17,200 --> 00:46:18,320 EFFORTS OVERALL, AMITA? 1198 00:46:18,320 --> 00:46:20,520 >>THERE'S NO CONGRESSIONAL LINE 1199 00:46:20,520 --> 00:46:21,360 ITEM SUFFICIENT, BASICALLY THE 1200 00:46:21,360 --> 00:46:23,560 BLANK LINE THERE WHICH IS RATHER 1201 00:46:23,560 --> 00:46:24,960 SHOCKING, SO THINKING WHAT MORE 1202 00:46:24,960 --> 00:46:26,960 CAN WE DO, WHAT MORE CAN BE 1203 00:46:26,960 --> 00:46:28,600 DONE, THIS IS SOMETHING THAT 1204 00:46:28,600 --> 00:46:32,200 ABSOLUTELY NEEDS TO BE FIXED. 1205 00:46:32,200 --> 00:46:33,960 >>YEAH, SO AS EMPLOYEES OF THE 1206 00:46:33,960 --> 00:46:37,560 EXECUTIVE BRANCH WE CAN'T LOBBY 1207 00:46:37,560 --> 00:46:39,320 CONGRESS, IN OUR BRIEFINGS WITH 1208 00:46:39,320 --> 00:46:39,680 CONGRESS. 1209 00:46:39,680 --> 00:46:43,200 WHAT WE HAVE PUT MONEY INTO, AND 1210 00:46:43,200 --> 00:46:47,720 THIS CAME THROUGH I THINK IN 1211 00:46:47,720 --> 00:46:49,600 THAT $3.3 BILLION FIGURE THAT 1212 00:46:49,600 --> 00:46:57,480 YOU SAW ON A SLIDE SLIDE, WE DD 1213 00:46:57,480 --> 00:46:59,000 THE DRUG DEVELOPMENT CENTERS 1214 00:46:59,000 --> 00:47:00,760 FOCUSING ON CORONAVIRUS AND ONE 1215 00:47:00,760 --> 00:47:10,280 OTHER MRNA VIRUS, THEY ALL 1216 00:47:10,280 --> 00:47:13,440 HAVE LINKS TO INDUSTRY WHICH WE 1217 00:47:13,440 --> 00:47:15,640 HOPE WILL AID IN THEIR LATE 1218 00:47:15,640 --> 00:47:16,840 DEVELOPMENT PATHWAY 1219 00:47:16,840 --> 00:47:17,280 SUCCESSFULLY. 1220 00:47:17,280 --> 00:47:18,680 THOSE WERE FUNDED -- GOT THREE 1221 00:47:18,680 --> 00:47:21,320 YEARS OF FUNDING IN ONE GIANT 1222 00:47:21,320 --> 00:47:23,280 LUMP, THERE'S NINE OF THEM, 1223 00:47:23,280 --> 00:47:25,120 WE'RE HOPEFUL IN SOME WAY, SHAPE 1224 00:47:25,120 --> 00:47:27,760 OR FORM, THIS WOULD BE IN FISCAL 1225 00:47:27,760 --> 00:47:29,120 YEAR, AFTER FISCAL YEAR 25, WE 1226 00:47:29,120 --> 00:47:30,920 CAN CONTINUE TO FUND THEM FOR 1227 00:47:30,920 --> 00:47:33,160 THE FIVE-YEAR PROJECTS THAT THEY 1228 00:47:33,160 --> 00:47:35,120 APPLIED FOR. 1229 00:47:35,120 --> 00:47:37,560 SO, THAT'S A BIG PROJECT FOR 1230 00:47:37,560 --> 00:47:39,280 ANTI-VIRAL DRUG DISCOVERY WHICH 1231 00:47:39,280 --> 00:47:42,680 WE THOUGHT WAS A HUGE GAP IN 1232 00:47:42,680 --> 00:47:43,600 PANDEMIC PREPAREDNESS. 1233 00:47:43,600 --> 00:47:46,280 THIS AFTERNOON IN THE DMID OPEN 1234 00:47:46,280 --> 00:47:48,920 SESSION OF SUBCOUNCIL, SORRY YOU 1235 00:47:48,920 --> 00:47:50,880 WON'T BE THERE AMITA BUT YOU CAN 1236 00:47:50,880 --> 00:47:53,840 WATCH ONLINE LATER, WE'LL BE 1237 00:47:53,840 --> 00:47:56,240 PROPOSING TO OUR SUBCOUNCIL THE 1238 00:47:56,240 --> 00:47:57,240 REVAMP INITIATIVE WHICH WILL 1239 00:47:57,240 --> 00:48:00,520 SORT OF DO THE SAME IN PANDEMIC 1240 00:48:00,520 --> 00:48:03,360 PREPAREDNESS FOR VIRAL FAMILIES 1241 00:48:03,360 --> 00:48:10,720 OF PANDEMIC CONCERN, FOCUS ON 1242 00:48:10,720 --> 00:48:12,240 VACCINES, AND MONOCLONAL 1243 00:48:12,240 --> 00:48:15,200 ANTIBODIES FOR PROTOTYPE 1244 00:48:15,200 --> 00:48:15,960 FAMILIES OF VIRUSES, A PROTOTYPE 1245 00:48:15,960 --> 00:48:17,720 VIRUS WITHIN A FAMILY THAT MIGHT 1246 00:48:17,720 --> 00:48:19,360 BE A FAMILY OF PANDEMIC CONCERN. 1247 00:48:19,360 --> 00:48:22,560 SO WE'RE DOING EVERYTHING WE CAN 1248 00:48:22,560 --> 00:48:24,400 TO MOVE THIS FIELD FORWARD WITH 1249 00:48:24,400 --> 00:48:26,280 THE RESOURCES THAT HAVE BEEN 1250 00:48:26,280 --> 00:48:29,440 ALLOCATED TO US IN THE FEDERAL 1251 00:48:29,440 --> 00:48:29,760 GOVERNMENT. 1252 00:48:29,760 --> 00:48:30,160 >>THANK YOU. 1253 00:48:30,160 --> 00:48:34,920 >>THAT'S ALL I CAN SAY. 1254 00:48:34,920 --> 00:48:36,520 >>OKAY. 1255 00:48:36,520 --> 00:48:37,960 SEEING NO ADDITIONAL QUESTIONS 1256 00:48:37,960 --> 00:48:39,000 I'M GOING TO -- 1257 00:48:39,000 --> 00:48:42,480 >>JUST ONE MORE QUESTION. 1258 00:48:42,480 --> 00:48:43,640 MY UNDERSTANDING, BECAUSE WE'VE 1259 00:48:43,640 --> 00:48:46,720 BEEN THINKING ABOUT THIS A LOT 1260 00:48:46,720 --> 00:48:49,120 WITH THE PEPFAR 20-YEAR 1261 00:48:49,120 --> 00:48:50,120 ANNIVERSARY ON SATURDAY, THE 1262 00:48:50,120 --> 00:48:51,760 40th ANNIVERSARY OF SO MANY 1263 00:48:51,760 --> 00:48:53,720 PROGRAMS, IS THAT ONE THING I'M 1264 00:48:53,720 --> 00:48:55,880 SEEING IS THAT BIPARTISAN 1265 00:48:55,880 --> 00:48:59,200 SUPPORT FOR HIV HAS NOT DIMMED. 1266 00:48:59,200 --> 00:49:01,360 I MEAN, IS THAT YOUR IMPRESSION 1267 00:49:01,360 --> 00:49:10,120 AS LEADERS AT NIAID THAT, YES, 1268 00:49:10,120 --> 00:49:13,160 THERE'S THIS POLITICIZATION OF 1269 00:49:13,160 --> 00:49:16,360 VIRUSES LIKE COVID BUT HIV A 1270 00:49:16,360 --> 00:49:17,760 COMMITMENT WITH THE SETBACKS 1271 00:49:17,760 --> 00:49:19,520 DURING THE COVID PANDEMIC, 1272 00:49:19,520 --> 00:49:20,640 FUNDING THAT AT NIAID LEVEL, AND 1273 00:49:20,640 --> 00:49:24,120 WHEN YOU -- I KNOW YOU CANNOT 1274 00:49:24,120 --> 00:49:26,320 BREAK IT DOWN TO EXACTLY HOW 1275 00:49:26,320 --> 00:49:28,760 MUCH HIV BUT ISN'T THAT ACCURATE 1276 00:49:28,760 --> 00:49:33,880 WE CAN BREATHE A SIGH OF RELIEF 1277 00:49:33,880 --> 00:49:38,800 THERE'S BIPARTISAN SUPPORT 1278 00:49:38,800 --> 00:49:39,960 ONGOING FOR HIV? 1279 00:49:39,960 --> 00:49:40,200 >>CARL? 1280 00:49:40,200 --> 00:49:41,200 DID WE LOSE CARL? 1281 00:49:41,200 --> 00:49:42,360 THE SIMPLE ANSWER IS YES, 1282 00:49:42,360 --> 00:49:43,160 SUPPORT IS THERE. 1283 00:49:43,160 --> 00:49:44,680 CARL, DO YOU WANT TO MAKE 1284 00:49:44,680 --> 00:49:45,360 FURTHER COMMENTS? 1285 00:49:45,360 --> 00:49:47,360 >>I DIDN'T HEAR THE QUESTION. 1286 00:49:47,360 --> 00:49:51,240 >>IS THERE STILL BIPARTISAN 1287 00:49:51,240 --> 00:49:51,840 SUPPORT FOR HIV? 1288 00:49:51,840 --> 00:49:54,320 >>YES, THERE IS. 1289 00:49:54,320 --> 00:49:59,040 CLEARLY WE GOT AN INCREASE THIS 1290 00:49:59,040 --> 00:49:59,360 YEAR. 1291 00:49:59,360 --> 00:49:59,680 >>YEAH, OKAY. 1292 00:49:59,680 --> 00:50:00,320 >>OKAY. 1293 00:50:00,320 --> 00:50:10,800 NEXT WE'RE GOING TO TURN TO 1294 00:50:13,080 --> 00:50:15,120 RENEE WEGRYZN, WITH AN OVERVIEW 1295 00:50:15,120 --> 00:50:16,000 OF THE NEW ARPA-H. 1296 00:50:16,000 --> 00:50:18,280 >>THANK YOU FOR INSTREETING ME 1297 00:50:18,280 --> 00:50:24,520 TO -- FOR INVITING ME. 1298 00:50:24,520 --> 00:50:27,400 I HAVE A FEW SLIDES TO TELL YOU 1299 00:50:27,400 --> 00:50:28,360 ABOUT ARPA-H'S MISSION, AND 1300 00:50:28,360 --> 00:50:31,640 WHERE WE'RE AT TODAY. 1301 00:50:31,640 --> 00:50:33,160 WE'LL HAVE TIME FOR Q&A AT THE 1302 00:50:33,160 --> 00:50:35,560 END IF I UNDERSTAND CORRECTLY. 1303 00:50:35,560 --> 00:50:37,760 BEFORE I JUMP IN THOUGH FOR THIS 1304 00:50:37,760 --> 00:50:38,840 GROUP IN PARTICULAR I'D LIKE TO 1305 00:50:38,840 --> 00:50:40,680 SHARE A LITTLE BIT OF MY 1306 00:50:40,680 --> 00:50:45,720 BACKGROUND IN TERMS OF HOW IT 1307 00:50:45,720 --> 00:50:46,600 TOUCHES ON INFECTIOUS DISEASE 1308 00:50:46,600 --> 00:50:49,680 WHEN I WAS A PROGRAM MANAGER AT 1309 00:50:49,680 --> 00:50:50,960 DARPA LAUNCHED FOUR PROGRAMS, 1310 00:50:50,960 --> 00:50:52,760 TWO DIRECTLY RELATED TO 1311 00:50:52,760 --> 00:50:54,360 INFECTIOUS DISEASE, ONE WAS 1312 00:50:54,360 --> 00:50:57,440 CALLED THE PREPARE PROGRAM WHERE 1313 00:50:57,440 --> 00:51:06,400 WE DEVELOPED NOVEL TYPES OF 1314 00:51:06,400 --> 00:51:06,880 ANTI-VIRALS, USED mRNA, 1315 00:51:06,880 --> 00:51:07,720 [AUDIO DISTORTION] 1316 00:51:07,720 --> 00:51:11,360 WE COULD HAVE BROAD SPECTRUM FLU 1317 00:51:11,360 --> 00:51:14,720 AND ULTIMATELY COVID, SARS-COV-2 1318 00:51:14,720 --> 00:51:17,040 ANTI-VIRALS THAT TARGETED NOT 1319 00:51:17,040 --> 00:51:19,760 THE SHAPE-SHIFTING SPIKE PROTEIN 1320 00:51:19,760 --> 00:51:21,920 SEQUENCES BUT RATHER THE GENOMIC 1321 00:51:21,920 --> 00:51:23,360 SEQUENCES THAT WERE HIGHLY 1322 00:51:23,360 --> 00:51:24,920 CONSERVED AMONG THE VIRUSES SO 1323 00:51:24,920 --> 00:51:26,640 THIS ALLOWED US TO HAVE PAN 1324 00:51:26,640 --> 00:51:27,840 VIRAL EFFICACY AND I HOPE THAT 1325 00:51:27,840 --> 00:51:31,400 GIVES YOU THE FLAVOR OF WHAT AN 1326 00:51:31,400 --> 00:51:32,680 ARPA-TYPE APPROACH TO INFECTIOUS 1327 00:51:32,680 --> 00:51:33,240 DISEASE AND MEDICAL SCIENCE 1328 00:51:33,240 --> 00:51:34,320 MIGHT LOOK LIKE. 1329 00:51:34,320 --> 00:51:38,240 NOT READY FOR THIS PANDEMIC BUT 1330 00:51:38,240 --> 00:51:40,000 CERTAINLY FOR FUTURE PANDEMICS 1331 00:51:40,000 --> 00:51:42,240 WE'RE HERE TO BE A CATALYST FOR 1332 00:51:42,240 --> 00:51:44,040 SOME OF THAT DEVELOPMENT. 1333 00:51:44,040 --> 00:51:45,640 AFTER DARPA I WENT OUT TO 1334 00:51:45,640 --> 00:51:47,880 INDUSTRY AND WAS AT GINGKO 1335 00:51:47,880 --> 00:51:52,600 BIOWORKS, WE ACTUALLY LAUNCHED A 1336 00:51:52,600 --> 00:51:55,240 NATIONWIDE COVID TESTING 1337 00:51:55,240 --> 00:51:55,720 PROGRAM, NON-TRADITIONAL 1338 00:51:55,720 --> 00:51:56,960 SETTINGS, K-12 SCHOOLS AND 1339 00:51:56,960 --> 00:51:58,520 AIRPORTS, SO WE ARGUED THAT THE 1340 00:51:58,520 --> 00:52:01,920 NEXT PANDEMIC WHETHER IT'S A NEW 1341 00:52:01,920 --> 00:52:04,080 VARIANT OF COVID OR FLU OR 1342 00:52:04,080 --> 00:52:06,400 WHATEVER THAT MIGHT BE WOULD BE 1343 00:52:06,400 --> 00:52:10,440 INTRODUCED THROUGH AN AIRPORT 1344 00:52:10,440 --> 00:52:12,800 AND TRAVEL, AND DETECTED EARLY, 1345 00:52:12,800 --> 00:52:13,840 SENTINEL POPULATION LIKE K-12. 1346 00:52:13,840 --> 00:52:16,600 AT THE CDC WEBSITE YOU CAN SEE A 1347 00:52:16,600 --> 00:52:17,680 DASHBOARD FOR GENOMIC 1348 00:52:17,680 --> 00:52:19,240 SURVEILLANCE THAT WAS ACTUALLY 1349 00:52:19,240 --> 00:52:21,400 BUILT FROM THE TEAM THAT I WAS A 1350 00:52:21,400 --> 00:52:24,920 PART OF WHEN I WAS AT GINGKO 1351 00:52:24,920 --> 00:52:25,160 BIOWORKS. 1352 00:52:25,160 --> 00:52:27,200 SO INFECTIOUS DISEASES IS NEAR 1353 00:52:27,200 --> 00:52:29,800 AND DEAR TO MY HEART, AND I WILL 1354 00:52:29,800 --> 00:52:31,240 SHARE ARPA-H, WE'RE NOT MANDATED 1355 00:52:31,240 --> 00:52:34,200 TO WORK ON ANY ONE DISEASE. 1356 00:52:34,200 --> 00:52:35,400 WE'RE DISEASE AGNOSTIC BUT 1357 00:52:35,400 --> 00:52:36,960 CERTAINLY THESE TYPES OF 1358 00:52:36,960 --> 00:52:39,440 CHALLENGES WOULD BE IN SCOPE FOR 1359 00:52:39,440 --> 00:52:40,120 US. 1360 00:52:40,120 --> 00:52:43,720 I'M GOING TO SHARE MY SCREEN 1361 00:52:43,720 --> 00:52:46,800 HERE, HOPEFULLY YOU CAN SEE 1362 00:52:46,800 --> 00:52:48,240 EVERYTHING CLEARLY. 1363 00:52:48,240 --> 00:52:50,720 OUR MISSION AT ARPA-H IS TO 1364 00:52:50,720 --> 00:52:52,360 ACCELERATE BETTER HEALTH 1365 00:52:52,360 --> 00:52:53,680 OUTCOMES FOR EVERYONE. 1366 00:52:53,680 --> 00:52:56,000 SUCCESS FOR US IS SOMETHING THAT 1367 00:52:56,000 --> 00:53:00,360 IS ADOPT AND USED BY A 1368 00:53:00,360 --> 00:53:03,520 COMMUNITY, IN THE WILD THE 1369 00:53:03,520 --> 00:53:05,640 AMERICAN PUBLIC HEALTH CARE 1370 00:53:05,640 --> 00:53:07,280 PROVIDERS, PATIENTS, EVERY 1371 00:53:07,280 --> 00:53:07,520 CITIZEN. 1372 00:53:07,520 --> 00:53:09,760 SO SINCE I WAS SWORN IN ON 1373 00:53:09,760 --> 00:53:12,760 OCTOBER 11 OF LAST YEAR, I'VE 1374 00:53:12,760 --> 00:53:13,960 BEEN HERE JUST OVER THREE 1375 00:53:13,960 --> 00:53:15,920 MONTHS, WE LANDED ON THIS 1376 00:53:15,920 --> 00:53:16,880 MISSION STATEMENT AS SOMETHING 1377 00:53:16,880 --> 00:53:20,480 THAT WILL STAND THE TEST OF TIME 1378 00:53:20,480 --> 00:53:23,680 IN ALIGNMENT WITH PRESIDENT 1379 00:53:23,680 --> 00:53:24,640 BIDEN'S VISION TO PURSUE IDEAS 1380 00:53:24,640 --> 00:53:27,400 TO BREAK THE MOLD HOW WE 1381 00:53:27,400 --> 00:53:28,680 APPROACH FUNDAMENTAL RESEARCH. 1382 00:53:28,680 --> 00:53:30,400 WE'RE NOT HERE TO REPLACE ANYONE 1383 00:53:30,400 --> 00:53:32,360 IN THE HEALTH CARE FUNDING 1384 00:53:32,360 --> 00:53:35,320 ECOSYSTEM BUT HERE TO AUGMENT, 1385 00:53:35,320 --> 00:53:37,240 CATALYZE, ACCELERATE BRINGING 1386 00:53:37,240 --> 00:53:38,640 SOME OF THOSE INNOVATIONS 1387 00:53:38,640 --> 00:53:38,880 FORWARD. 1388 00:53:38,880 --> 00:53:40,200 SO BASED ON THE PRESIDENT'S 1389 00:53:40,200 --> 00:53:43,960 VISION WE'RE TAKING THIS AS OUR 1390 00:53:43,960 --> 00:53:45,680 MOMENT, ERA OF COMPLEX 1391 00:53:45,680 --> 00:53:48,200 TECHNOLOGIES, THAT LEAD TO 1392 00:53:48,200 --> 00:53:49,520 DISRUPTIONS WHETHER ECONOMIC, 1393 00:53:49,520 --> 00:53:50,000 SOCIAL, PANDEMICS CAUSE 1394 00:53:50,000 --> 00:53:52,240 DISRUPTIONS BUT IN A CREDIBLE 1395 00:53:52,240 --> 00:53:55,000 TIME WHERE BIOTECHNOLOGIES AND 1396 00:53:55,000 --> 00:53:56,040 INNOVATION ARE REALLY ADVANCING 1397 00:53:56,040 --> 00:53:57,040 THE STATE OF THE ART, POWERFUL 1398 00:53:57,040 --> 00:53:59,800 BIOLOGY IN THE FORM OF PANDEMIC 1399 00:53:59,800 --> 00:54:01,680 CAN COMBATED BY POWERFUL BIOLOGY 1400 00:54:01,680 --> 00:54:03,720 IN THE FORM OF mRNA VACCINES 1401 00:54:03,720 --> 00:54:05,160 AS JUST ONE EXAMPLE. 1402 00:54:05,160 --> 00:54:06,720 THE WAY THAT WE WANT TO PURSUE 1403 00:54:06,720 --> 00:54:08,960 THIS VISION, OUR PROMISE IS TO 1404 00:54:08,960 --> 00:54:11,080 HIRE PROGRAM MANAGERS WHO ARE 1405 00:54:11,080 --> 00:54:12,960 GOING TO BUILD, CREATE, DESIGN 1406 00:54:12,960 --> 00:54:15,440 THE SOLUTIONS FOR THIS BETTER 1407 00:54:15,440 --> 00:54:17,320 HEALTH CARE FUTURE. 1408 00:54:17,320 --> 00:54:19,280 AND SO VERY UNIQUE IN TERMS OF 1409 00:54:19,280 --> 00:54:21,240 THE BUSINESS STRUCTURE, I WON'T 1410 00:54:21,240 --> 00:54:23,360 SET A TECHNICAL VISION OF THESE 1411 00:54:23,360 --> 00:54:25,440 ARE THE TEN PROGRAMS, FOR 1412 00:54:25,440 --> 00:54:26,520 EXAMPLE, THAT WE'LL FUND THIS 1413 00:54:26,520 --> 00:54:26,840 YEAR. 1414 00:54:26,840 --> 00:54:29,600 INSTEAD WE SEEK OUT THOSE 1415 00:54:29,600 --> 00:54:31,240 VISIONARIES WHO CAN COME JOIN 1416 00:54:31,240 --> 00:54:33,080 ARPA-H FOR A TERM APPOINTMENT SO 1417 00:54:33,080 --> 00:54:35,200 THE CONGRESS HAS ALLOWED US TO 1418 00:54:35,200 --> 00:54:37,080 HAVE A TERM APPOINTMENT BASE OF 1419 00:54:37,080 --> 00:54:38,560 THREE YEARS RENEWABLE FOR UP TO 1420 00:54:38,560 --> 00:54:39,920 ANOTHER THREE, SO THAT PROGRAM 1421 00:54:39,920 --> 00:54:42,760 MANAGER COMES IN, NOT ONLY WITH 1422 00:54:42,760 --> 00:54:44,160 A GREAT CV BUT SPECIFIC PROBLEM 1423 00:54:44,160 --> 00:54:47,000 IN HEALTH IN MIND THEY WANT TO 1424 00:54:47,000 --> 00:54:47,200 SOLVE. 1425 00:54:47,200 --> 00:54:49,000 I ANTICIPATE THAT THEY WILL 1426 00:54:49,000 --> 00:54:50,560 LAUNCH ABOUT A PROGRAM A YEAR 1427 00:54:50,560 --> 00:54:51,840 BEFORE THEY LEAVE THE 1428 00:54:51,840 --> 00:54:52,320 ORGANIZATION. 1429 00:54:52,320 --> 00:54:53,360 AND SO I'LL TALK A LITTLE BIT 1430 00:54:53,360 --> 00:54:55,440 MORE ABOUT THAT MODEL BUT I 1431 00:54:55,440 --> 00:54:56,640 THINK IT'S A REALLY IMPORTANT 1432 00:54:56,640 --> 00:54:58,280 PREMISE TO UNDERSTAND HOW IF YOU 1433 00:54:58,280 --> 00:54:59,520 LOOK AT ARPA-H THIS YEAR, 1434 00:54:59,520 --> 00:55:00,680 COMPARED TO FIVE YEARS FROM NOW, 1435 00:55:00,680 --> 00:55:02,680 IT'S GOING TO LOOK LIKE A 1436 00:55:02,680 --> 00:55:04,000 TOTALLY DIFFERENT AGENCY IN 1437 00:55:04,000 --> 00:55:05,080 TERMS OF PROJECTS WE'RE FUNDING 1438 00:55:05,080 --> 00:55:06,920 BECAUSE THEY ARE DRIVEN BY THOSE 1439 00:55:06,920 --> 00:55:07,640 PROGRAM MANAGERS. 1440 00:55:07,640 --> 00:55:09,680 WE WERE LOOKING FOR THOSE 1441 00:55:09,680 --> 00:55:13,840 VISIONARIES WHO WANT TO IMAGINE 1442 00:55:13,840 --> 00:55:16,320 A FUTURE WITH THERAPIES COULD BE 1443 00:55:16,320 --> 00:55:18,120 PROGRAMMED FOR EACH NEW DISEASE 1444 00:55:18,120 --> 00:55:23,160 TARGET, GREAT PROOFS OF CONCEPT 1445 00:55:23,160 --> 00:55:26,200 IN PARKINSON'S BUT DOSE IN SCALE 1446 00:55:26,200 --> 00:55:27,400 IS MISSING, MRIs REQUIRE A 1447 00:55:27,400 --> 00:55:29,400 CENTRAL SYSTEM TO DO THE MRI, 1448 00:55:29,400 --> 00:55:30,880 WHAT IF WE CAN DELIVER THIS IN 1449 00:55:30,880 --> 00:55:32,440 THE COMFORT OF SOMEBODY'S HOME? 1450 00:55:32,440 --> 00:55:34,200 MORE AND MORE HOSPITALS ARE 1451 00:55:34,200 --> 00:55:35,400 CLOSING, HOW DO WE BRING MORE 1452 00:55:35,400 --> 00:55:37,240 CARE TO THE HOME? 1453 00:55:37,240 --> 00:55:39,000 EXAMPLE OF THE PERSONALIZED 1454 00:55:39,000 --> 00:55:39,680 CANCER VACCINE, COSTING THE SAME 1455 00:55:39,680 --> 00:55:42,600 AS A CUP OF COFFEE, THESE ARE 1456 00:55:42,600 --> 00:55:45,800 AREN'T REALLY PROBLEMS AT 1457 00:55:45,800 --> 00:55:47,320 ARPA-H, WE'RE EXPECTING PROGRAM 1458 00:55:47,320 --> 00:55:49,440 MANAGERS THIS QUARTER TO REPLACE 1459 00:55:49,440 --> 00:55:51,040 STATEMENTS WITH ACTUAL PROGRAMS 1460 00:55:51,040 --> 00:55:53,440 WE'LL BE RUNNING BUT WANT TO 1461 00:55:53,440 --> 00:55:55,760 INSPIRE WHAT THOSE PROGRAMS 1462 00:55:55,760 --> 00:55:57,520 COULD LOOK LIKE. 1463 00:55:57,520 --> 00:55:59,240 ARPA-H IS AN ORGANIZATION WITHIN 1464 00:55:59,240 --> 00:56:00,360 BOTH HHS AND NIH. 1465 00:56:00,360 --> 00:56:01,640 IT'S AN INTERESTING STRUCTURE 1466 00:56:01,640 --> 00:56:04,960 THAT I THINK IS WORTH SPENDING A 1467 00:56:04,960 --> 00:56:07,120 MINUTE ON HOW THIS WORKS. 1468 00:56:07,120 --> 00:56:09,280 THE ARPA-H DIRECTOR, I REPORT TO 1469 00:56:09,280 --> 00:56:12,440 SECRETARY BECERRA, HE'S MY BOSS. 1470 00:56:12,440 --> 00:56:13,920 BUT WE'RE AN AGENCY WITHIN NIH. 1471 00:56:13,920 --> 00:56:16,240 SO WHAT THAT MEANS IS WE'RE VERY 1472 00:56:16,240 --> 00:56:18,080 LUCKY TO BE WORKING WITH SUBJECT 1473 00:56:18,080 --> 00:56:21,600 MATTER EXPERTS LIKE THE FOLKS AT 1474 00:56:21,600 --> 00:56:22,920 NIAID TO UNDERSTAND SOME OF THE 1475 00:56:22,920 --> 00:56:24,520 BIG PROBLEMS THAT WE COULD 1476 00:56:24,520 --> 00:56:26,080 PURSUE GOING FORWARD TO TAP INTO 1477 00:56:26,080 --> 00:56:27,720 THEIR NETWORKS TO LOOK FOR THOSE 1478 00:56:27,720 --> 00:56:29,480 PROGRAM MANAGERS THAT WE WANT TO 1479 00:56:29,480 --> 00:56:31,440 HIRE, AND AS WE LAUNCH PROGRAMS 1480 00:56:31,440 --> 00:56:33,520 TO WORK WITH THEM AS SUBJECT 1481 00:56:33,520 --> 00:56:35,400 MATTER EXPERTS TO HELP INFORM 1482 00:56:35,400 --> 00:56:37,320 AND GUIDE OUR PROGRAMS EVEN IF 1483 00:56:37,320 --> 00:56:40,640 WE SET THE MILESTONES AND 1484 00:56:40,640 --> 00:56:41,600 METRICS, WE DEFINITELY BENEFIT 1485 00:56:41,600 --> 00:56:44,240 FROM HAVING THAT SUBJECT MATTER 1486 00:56:44,240 --> 00:56:46,080 EXPERTISE CLOSE TO US. 1487 00:56:46,080 --> 00:56:47,520 SO, UNDER ARPA-H WE HAVE THE 1488 00:56:47,520 --> 00:56:48,920 PROGRAM MANAGERS AND THE 1489 00:56:48,920 --> 00:56:51,040 BUSINESS TEAM MEMBERS, I'M HAPPY 1490 00:56:51,040 --> 00:56:52,840 TO SAY WE'VE HIRED ABOUT 100 1491 00:56:52,840 --> 00:56:55,520 BUSINESS TEAM MEMBERS AND SO 1492 00:56:55,520 --> 00:56:57,240 THIS IS - IN A SHORT TIME WE'RE 1493 00:56:57,240 --> 00:56:58,560 TRYING TO CREATE THE SIDE OF THE 1494 00:56:58,560 --> 00:57:00,560 HOUSE AS I CALL IT TO BE ABLE TO 1495 00:57:00,560 --> 00:57:01,560 SUPPORT A PROGRAM MANAGER WHEN 1496 00:57:01,560 --> 00:57:03,480 THEY WALK IN THE DOOR. 1497 00:57:03,480 --> 00:57:05,000 SO THINK THE COMMUNICATIONS 1498 00:57:05,000 --> 00:57:07,560 TEAM, OUR CONTRACTING TEAM, OUR 1499 00:57:07,560 --> 00:57:08,200 HUMAN RESOURCES TEAM, EVERYBODY 1500 00:57:08,200 --> 00:57:09,960 THAT'S GOING TO NEED TO BE IN 1501 00:57:09,960 --> 00:57:11,840 PLACE WHEN THE PROGRAM MANAGER 1502 00:57:11,840 --> 00:57:13,840 ARRIVES TO LAUNCH THOSE PROGRAMS 1503 00:57:13,840 --> 00:57:16,200 AS QUICKLY AS POSSIBLE. 1504 00:57:16,200 --> 00:57:18,800 THE PRESIDENT STARTED OUT WITH 1505 00:57:18,800 --> 00:57:19,920 INITIAL BUDGET OF $1 BILLION TO 1506 00:57:19,920 --> 00:57:24,080 GET STARTED IN FISCAL YEAR 2023, 1507 00:57:24,080 --> 00:57:24,840 WE'VE RECEIVED ANOTHER 1508 00:57:24,840 --> 00:57:26,360 $1.5 BILLION TO GO AFTER THESE 1509 00:57:26,360 --> 00:57:27,720 BIG PROGRAMS. 1510 00:57:27,720 --> 00:57:30,120 WE ANTICIPATE THAT EACH PROGRAM 1511 00:57:30,120 --> 00:57:33,160 WILL RUN BETWEEN 50 AND $150 1512 00:57:33,160 --> 00:57:36,200 MILLION PER PROGRAM, WHICH IS 1513 00:57:36,200 --> 00:57:37,120 BASED ON AVERAGE EXPERIENCE FROM 1514 00:57:37,120 --> 00:57:38,320 PRIOR DARPA EXPERIENCE. 1515 00:57:38,320 --> 00:57:40,840 WE DON'T HAVE INTERNAL RESEARCH 1516 00:57:40,840 --> 00:57:41,040 LABS. 1517 00:57:41,040 --> 00:57:43,440 WE'RE EXCLUSIVELY EXTRAMURAL AND 1518 00:57:43,440 --> 00:57:44,880 DISEASE AGNOSTIC, AND PROGRAM 1519 00:57:44,880 --> 00:57:46,440 MANAGERS WILL DRIVE THE 1520 00:57:46,440 --> 00:57:48,640 DECISIONS BUT ALSO THE DECISION 1521 00:57:48,640 --> 00:57:48,880 MAKING. 1522 00:57:48,880 --> 00:57:52,520 SO WE'RE EXEMPT FROM SOME OF THE 1523 00:57:52,520 --> 00:57:53,880 NIH POLICIES INCLUDING NEEDING A 1524 00:57:53,880 --> 00:57:54,720 STUDY SECTION. 1525 00:57:54,720 --> 00:57:56,600 IN ORDER FOR US TO TAKE BIG 1526 00:57:56,600 --> 00:57:59,000 RISKS AND GO AFTER THOSE 1527 00:57:59,000 --> 00:57:59,760 CATALYTIC PROJECTS IN HEALTH 1528 00:57:59,760 --> 00:58:01,400 THAT ARE UNABLE TO BE FUNDED 1529 00:58:01,400 --> 00:58:02,840 ELSEWHERE IN THE FEDERAL 1530 00:58:02,840 --> 00:58:04,240 GOVERNMENT, WE CAN TAKE THOSE 1531 00:58:04,240 --> 00:58:06,640 RISKS BY HAVING AN INDIVIDUAL AS 1532 00:58:06,640 --> 00:58:09,040 A DECISION MAKER MOVING FORWARD 1533 00:58:09,040 --> 00:58:09,760 ON THOSE PROGRAMS. 1534 00:58:09,760 --> 00:58:13,200 AND SO WITH THIS MODEL WE INTEND 1535 00:58:13,200 --> 00:58:14,640 TO CREATE A FLYWHEEL OF PROGRAM 1536 00:58:14,640 --> 00:58:16,280 MANAGERS WHO COME INTO THE 1537 00:58:16,280 --> 00:58:17,800 AGENCY FOR 3 TO 6 YEARS, AND 1538 00:58:17,800 --> 00:58:19,360 PROGRAMS THEY ARE GOING TO 1539 00:58:19,360 --> 00:58:21,000 LAUNCH, ONE PER YEAR, THAT LAST 1540 00:58:21,000 --> 00:58:23,200 TWO TO FOUR YEARS AND THOSE 1541 00:58:23,200 --> 00:58:25,480 PROGRAMS ALSO LEAVE THE 1542 00:58:25,480 --> 00:58:28,240 ORGANIZATION, WE MUST TRANSITION 1543 00:58:28,240 --> 00:58:30,000 THEM TO FUNDERS AND ENTITIES 1544 00:58:30,000 --> 00:58:31,960 OUTSIDE OF ARPA-H. 1545 00:58:31,960 --> 00:58:34,360 SO LONG-TERM FUNDER MIGHT BE NIH 1546 00:58:34,360 --> 00:58:36,760 BUT WE COULD WORK TO SPIN OUT A 1547 00:58:36,760 --> 00:58:39,200 COMPANY AND IT BECOMES 1548 00:58:39,200 --> 00:58:40,040 COMMERCIALIZED, THE GOVERNMENT 1549 00:58:40,040 --> 00:58:42,560 CAN BECOME A CUSTOMER FOR THAT 1550 00:58:42,560 --> 00:58:43,560 SOLUTION LAUNCHED FROM ARPA-H. 1551 00:58:43,560 --> 00:58:45,400 A LITTLE BIT MORE ON THE MODEL. 1552 00:58:45,400 --> 00:58:47,200 AS I MENTIONED A PROGRAM MANAGER 1553 00:58:47,200 --> 00:58:49,360 COMES IN, NOT ONLY WITH THEIR 1554 00:58:49,360 --> 00:58:50,600 GREAT BACKGROUND BUT THE 1555 00:58:50,600 --> 00:58:51,680 CHALLENGE AND PROBLEM THEY WANT 1556 00:58:51,680 --> 00:58:55,840 TO SOLVE, THAT MAGIC 1557 00:58:55,840 --> 00:58:56,920 COMBINATION, THEY COME IN, IN 1558 00:58:56,920 --> 00:58:58,760 THREE TO FOUR MONTHS THEY WRITE 1559 00:58:58,760 --> 00:59:00,280 A SOLICITATION, CALL FOR 1560 00:59:00,280 --> 00:59:01,480 PROPOSALS, TALK TO EXPERTS, 1561 00:59:01,480 --> 00:59:03,680 MAKING SURE THEY ARE HITTING 1562 00:59:03,680 --> 00:59:04,680 THOSE VERY AMBITIOUS METRICS 1563 00:59:04,680 --> 00:59:06,760 THEY ARE GOING TO NEED, IF THEY 1564 00:59:06,760 --> 00:59:09,320 ARE GOING TO LAUNCH A PROGRAM. 1565 00:59:09,320 --> 00:59:11,040 THEY ARE GOING TO SELECT THE 1566 00:59:11,040 --> 00:59:13,560 TEAMS THEY FUND, PERFORMERS THEY 1567 00:59:13,560 --> 00:59:16,320 FUND UNDER THIS PROGRAM. 1568 00:59:16,320 --> 00:59:17,960 ARPA-H PROGRAMS, THE MODEL, IS 1569 00:59:17,960 --> 00:59:21,200 VERY INTENSIVE, WE CALL IT HIGH 1570 00:59:21,200 --> 00:59:22,200 CONTACT PROGRAM MANAGEMENT. 1571 00:59:22,200 --> 00:59:24,080 AND SO WHEN A P.M., PROGRAM 1572 00:59:24,080 --> 00:59:25,280 MANAGER, IS MANAGING A PROGRAM 1573 00:59:25,280 --> 00:59:28,240 THEY WILL BE ENGAGED WITH TEAMS 1574 00:59:28,240 --> 00:59:29,640 ON A MONTHLY, SOMETIMES EVEN 1575 00:59:29,640 --> 00:59:31,400 WEEKLY BASIS, TO MAKE SURE THEY 1576 00:59:31,400 --> 00:59:32,080 ARE MAKING PROGRESS AGAINST 1577 00:59:32,080 --> 00:59:32,840 THEIR GOALS. 1578 00:59:32,840 --> 00:59:34,880 THEY WILL NOT BE GRANTS. 1579 00:59:34,880 --> 00:59:36,320 THEY WILL BE COOPERATIVE 1580 00:59:36,320 --> 00:59:36,680 AGREEMENTS. 1581 00:59:36,680 --> 00:59:37,960 THEY WILL BE CONTRACTS. 1582 00:59:37,960 --> 00:59:40,920 THEY WILL BE VERY FOCUSED ON 1583 00:59:40,920 --> 00:59:43,640 ACHIEVING THAT SOLUTION. 1584 00:59:43,640 --> 00:59:44,520 ACTIVE PROGRAM MANAGEMENT ALSO 1585 00:59:44,520 --> 00:59:45,840 MEANS CUTTING FUNDING FOR A TEAM 1586 00:59:45,840 --> 00:59:47,920 IF THEY ARE NOT MEETING THOSE 1587 00:59:47,920 --> 00:59:49,480 METRICS AND GOALS, SO IT'S NOT 1588 00:59:49,480 --> 00:59:50,720 UNUSUAL TO SEE AT THE BEGINNING 1589 00:59:50,720 --> 00:59:52,960 OF A PROGRAM YOU MAY HAVE THREE 1590 00:59:52,960 --> 00:59:54,480 OR FIVE PERFORMERS THAT EACH 1591 00:59:54,480 --> 00:59:56,360 BRING A DIFFERENT APPROACH TO 1592 00:59:56,360 --> 00:59:58,200 SOLVING A BIG PROBLEM IN HEALTH, 1593 00:59:58,200 --> 00:59:59,960 AT THE END YOU MAY HAVE ONLY ONE 1594 00:59:59,960 --> 01:00:01,600 OR TWO TEAMS THAT ACTUALLY MAKE 1595 01:00:01,600 --> 01:00:05,640 IT TO THE END AND HAVE THEIR 1596 01:00:05,640 --> 01:00:08,600 CAPABILITY LAUNCHED. 1597 01:00:08,600 --> 01:00:09,680 BECAUSE OF THIS, SUCCESS TO 1598 01:00:09,680 --> 01:00:12,720 TRANSITION OUT OF THE AGENCY, 1599 01:00:12,720 --> 01:00:14,520 I'LL SHARE INFORMATION ABOUT A 1600 01:00:14,520 --> 01:00:16,120 WHOLE OFFICE WE'RE STANDING UP 1601 01:00:16,120 --> 01:00:16,520 AROUND TRANSITION. 1602 01:00:16,520 --> 01:00:18,440 WE HAVE TO HELP THESE PROGRAMS 1603 01:00:18,440 --> 01:00:19,520 START, EVERYTHING FROM EVEN 1604 01:00:19,520 --> 01:00:21,520 BEFORE PROGRAM LAUNCHES, MAKE 1605 01:00:21,520 --> 01:00:23,600 SURE WE UNDERSTAND REIMBURSEMENT 1606 01:00:23,600 --> 01:00:24,880 MODELS, MAKE SURE WE'VE DONE 1607 01:00:24,880 --> 01:00:26,000 MARKET ASSESSMENT. 1608 01:00:26,000 --> 01:00:28,200 WE CAN PURSUE A CONCEPT EVEN IF 1609 01:00:28,200 --> 01:00:29,400 THERE ISN'T A MARKET YET BUT 1610 01:00:29,400 --> 01:00:30,480 WANT TO UNDERSTAND THAT AND SAY 1611 01:00:30,480 --> 01:00:32,080 ARE WE GOING TO HAVE TO DEVELOP 1612 01:00:32,080 --> 01:00:34,520 THIS MARKET OVER THE COURSE OF 1613 01:00:34,520 --> 01:00:35,320 THE PROGRAM? 1614 01:00:35,320 --> 01:00:37,600 AGAIN, WE'RE PART OF THE ENTIRE 1615 01:00:37,600 --> 01:00:38,440 HEALTH ECOSYSTEM. 1616 01:00:38,440 --> 01:00:40,440 OUR CUSTOMERS ARE THE PUBLIC, 1617 01:00:40,440 --> 01:00:43,080 HEALTH CARE PROVIDERS, PATIENT 1618 01:00:43,080 --> 01:00:45,800 GROUPS, PERFORMERS WILL BE 1619 01:00:45,800 --> 01:00:48,120 ACADEMIA AND INDUSTRY, 1620 01:00:48,120 --> 01:00:50,600 STAKEHOLDERS OF COURSE INCLUDE 1621 01:00:50,600 --> 01:00:53,880 NIH, FDA, CMS, PARTS OF HHS, 1622 01:00:53,880 --> 01:00:56,400 MAKE STAKEHOLDERS, NGOs, AND 1623 01:00:56,400 --> 01:00:58,160 THOSE ACROSS THE HEALTHCARE 1624 01:00:58,160 --> 01:00:58,480 ECOSYSTEM. 1625 01:00:58,480 --> 01:00:59,920 IT'S HELPFUL TO TAKE A MOMENT TO 1626 01:00:59,920 --> 01:01:02,560 UNDERSTAND HOW WE FRAME THESE 1627 01:01:02,560 --> 01:01:04,720 WELL-DEFINED PROBLEMS IN HEALTH. 1628 01:01:04,720 --> 01:01:07,560 WE'VE ADOPTED AND MODIFIED WHAT 1629 01:01:07,560 --> 01:01:15,200 ARE CALLED HIGH HEILMEIER 1630 01:01:15,200 --> 01:01:15,480 QUESTIONS. 1631 01:01:15,480 --> 01:01:16,200 GEORGE HEILMEIER SAID EIGHT 1632 01:01:16,200 --> 01:01:23,880 QUESTIONS HOW YOU DEFINE, WHAT 1633 01:01:23,880 --> 01:01:28,160 IS THE PROBLEM YOU'RE TRYING TO 1634 01:01:28,160 --> 01:01:30,800 SOLVE, HOW DOES IT GET DONE, 1635 01:01:30,800 --> 01:01:32,440 WHAT'S NEW ABOUT YOUR APPROACH? 1636 01:01:32,440 --> 01:01:35,800 WHY ARE YOU EXCITED? 1637 01:01:35,800 --> 01:01:37,160 IS THERE INNOVATION NOW 1638 01:01:37,160 --> 01:01:39,000 PUBLISHED OR PATENTED THAT WE 1639 01:01:39,000 --> 01:01:41,200 CAN REALLY BE EXCITED ABOUT? 1640 01:01:41,200 --> 01:01:42,840 WHO CARES IF IT'S SUCCESSFUL, 1641 01:01:42,840 --> 01:01:46,640 WILL THIS MAKE A DIFFERENCE? 1642 01:01:46,640 --> 01:01:47,880 LET'S QUANTITATE THE IMPACT, IS 1643 01:01:47,880 --> 01:01:49,160 IT WORTH INVESTING IN? 1644 01:01:49,160 --> 01:01:51,680 WHAT ARE RISKS THAT CAN PREVENT 1645 01:01:51,680 --> 01:01:53,000 YOU FROM REACHING OBJECTIVES BUT 1646 01:01:53,000 --> 01:01:55,440 OF THE PROGRAM ITSELF? 1647 01:01:55,440 --> 01:01:57,560 IS THIS TECHNOLOGY -- YOU KNOW, 1648 01:01:57,560 --> 01:01:59,520 WE'VE HEARD THIS, THERE ARE 1649 01:01:59,520 --> 01:02:00,160 BIOTECHNOLOGIES YOU SHOULDN'T 1650 01:02:00,160 --> 01:02:00,960 JUST DO EVERYTHING, RIGHT? 1651 01:02:00,960 --> 01:02:02,760 HOW DO WE PUT THE GUARD RAILS ON 1652 01:02:02,760 --> 01:02:04,920 THINGS THAT COULD BE MISUSED? 1653 01:02:04,920 --> 01:02:07,640 HOW WILL IT TAKE, HOW MUCH WILL 1654 01:02:07,640 --> 01:02:08,760 IT COST? 1655 01:02:08,760 --> 01:02:10,960 WHAT ARE OUR MIDTERM AND FINAL 1656 01:02:10,960 --> 01:02:11,920 EXAMS FOR SUCCESS? 1657 01:02:11,920 --> 01:02:14,320 THE PROGRAM MANAGER WILL DO THAT 1658 01:02:14,320 --> 01:02:16,280 AS THEY MOVE FORWARD. 1659 01:02:16,280 --> 01:02:18,360 WE'VE ADDED TWO NEW QUESTIONS 1660 01:02:18,360 --> 01:02:19,480 FOR ARPA-H. 1661 01:02:19,480 --> 01:02:20,800 ONE IS WE WANT TO ENSURE 1662 01:02:20,800 --> 01:02:23,400 EQUITABLE ACCESS FOR ALL PEOPLE. 1663 01:02:23,400 --> 01:02:24,400 OUR MISSION IS TO ACCELERATE 1664 01:02:24,400 --> 01:02:33,920 BETTER HEALTH OUTCOMES, AND HOW 1665 01:02:33,920 --> 01:02:35,360 WILL WE ADDRESS COST, DESIGNING 1666 01:02:35,360 --> 01:02:37,640 TOOLS PEOPLE WANT TO ADOPT. 1667 01:02:37,640 --> 01:02:39,040 WE WANT FOMO AROUND OUR 1668 01:02:39,040 --> 01:02:40,800 PROGRAMS, I WANT THAT, ARPA-H IS 1669 01:02:40,800 --> 01:02:42,000 CATALYZING SOMETHING THAT'S 1670 01:02:42,000 --> 01:02:43,640 GOING TO MAKE AN IMPACT. 1671 01:02:43,640 --> 01:02:45,960 FINALLY NUMBER 10, HOW MIGHT 1672 01:02:45,960 --> 01:02:47,360 THIS PROGRAM BE MISPERCEIVED OR 1673 01:02:47,360 --> 01:02:47,640 MISUSED? 1674 01:02:47,640 --> 01:02:49,480 ALL OFS 1675 01:02:49,480 --> 01:02:51,040 ALL OF US IN THE FEDERAL 1676 01:02:51,040 --> 01:02:53,520 GOVERNMENT AND BEYOND ARE 1677 01:02:53,520 --> 01:02:54,920 DEALING WITH MISINFORMATION 1678 01:02:54,920 --> 01:02:56,200 SPECIALLY AROUND HEALTHCARE 1679 01:02:56,200 --> 01:02:57,040 TECHNOLOGY AND WANT TO 1680 01:02:57,040 --> 01:02:59,720 UNDERSTAND AND GET AHEAD AND 1681 01:02:59,720 --> 01:03:00,720 MAKE SURE WE'RE MAKING CLEAR 1682 01:03:00,720 --> 01:03:02,360 WHAT ARE TECHNOLOGIES WE'RE 1683 01:03:02,360 --> 01:03:03,560 ADDRESSING, EVEN WHEN TECHNOLOGY 1684 01:03:03,560 --> 01:03:06,560 IS READY TO GO LIVE MAKE SURE 1685 01:03:06,560 --> 01:03:08,360 WE'RE ADDRESSING THESE 1686 01:03:08,360 --> 01:03:09,920 COMMUNICATION CHALLENGES. 1687 01:03:09,920 --> 01:03:11,880 SO A TYPICAL PROGRAM LIFE CYCLE 1688 01:03:11,880 --> 01:03:14,080 FROM IDEAS TO SOLUTIONS IN THE 1689 01:03:14,080 --> 01:03:15,000 REAL WORLD COMES FROM DESIGNING 1690 01:03:15,000 --> 01:03:16,320 THOSE PROGRAMS. 1691 01:03:16,320 --> 01:03:18,240 THEY HAVE TO BE NON-REDUNDANT 1692 01:03:18,240 --> 01:03:22,920 WITH THE REST OF THE FEDERAL 1693 01:03:22,920 --> 01:03:25,800 GOVERNMENT, WITHIN THE HEILMEIER 1694 01:03:25,800 --> 01:03:26,880 FRAMEWORK, HIGH RISK AND HIGH 1695 01:03:26,880 --> 01:03:27,680 CONSEQUENCE. 1696 01:03:27,680 --> 01:03:31,800 NIH IS A STAKEHOLDER OF VENTURE 1697 01:03:31,800 --> 01:03:32,320 CAPITAL FIRM. 1698 01:03:32,320 --> 01:03:36,400 WE WANT THOSE INSIGHTS. 1699 01:03:36,400 --> 01:03:38,920 PMs WILL EXECUTE AND MEASURE 1700 01:03:38,920 --> 01:03:40,200 THROUGHOUT, WE CONSIDER THEM THE 1701 01:03:40,200 --> 01:03:41,840 CEO OF THE PROGRAM, MAKING SURE 1702 01:03:41,840 --> 01:03:43,080 THIS IS OPERATING. 1703 01:03:43,080 --> 01:03:44,800 THIS IS REALLY MOVING FORWARD, 1704 01:03:44,800 --> 01:03:46,680 THEY ARE SPENDING MONEY, A GOOD 1705 01:03:46,680 --> 01:03:50,040 STEWARD OF TAXPAYER DOLLARS. 1706 01:03:50,040 --> 01:03:51,480 IT'S A VERY ACTIVE ROLE DURING 1707 01:03:51,480 --> 01:03:53,120 THE LIFE CYCLE OF THE PROGRAM. 1708 01:03:53,120 --> 01:03:56,080 WITH THE GOAL OF ADVANCING THE 1709 01:03:56,080 --> 01:03:59,680 STATE OF THE ART, WELL BEYOND 1710 01:03:59,680 --> 01:04:02,200 100X, NOT EVOLUTIONARY OR 1711 01:04:02,200 --> 01:04:02,880 INCREMENTAL BUT REVOLUTIONARY 1712 01:04:02,880 --> 01:04:04,400 DISRUPTIVE CHANGES WE'RE LOOKING 1713 01:04:04,400 --> 01:04:05,920 FOR IN THESE PROGRAMS. 1714 01:04:05,920 --> 01:04:08,320 AND WE WANT TO DE-RISK THESE 1715 01:04:08,320 --> 01:04:09,840 INVESTMENTS THAT WE'VE MADE FOR 1716 01:04:09,840 --> 01:04:11,600 OTHERS THAT CAN FOLLOW ON BEHIND 1717 01:04:11,600 --> 01:04:12,160 US. 1718 01:04:12,160 --> 01:04:14,920 I THINK FOR THIS AUDIENCE IT'S 1719 01:04:14,920 --> 01:04:16,960 HELPFUL TO THINK HOW SHOULD 1720 01:04:16,960 --> 01:04:20,800 NIAID AND NIH THINK ABOUT 1721 01:04:20,800 --> 01:04:22,520 [AUDIO DISTORTION] 1722 01:04:22,520 --> 01:04:26,240 EARLY IN THE DESIGN TO HAVE 1723 01:04:26,240 --> 01:04:30,640 BETTER UNDERSTANDING OF THE 1724 01:04:30,640 --> 01:04:31,080 PROBLEM IN HEALTH. 1725 01:04:31,080 --> 01:04:31,840 [AUDIO DISTORTION] 1726 01:04:31,840 --> 01:04:35,960 WE WANT TO MAKE SURE THAT WE'RE 1727 01:04:35,960 --> 01:04:36,360 NOT THE 1728 01:04:36,360 --> 01:04:37,760 [AUDIO DISTORTION] 1729 01:04:37,760 --> 01:04:40,920 WE'RE BUILDING A PERFORMER TEAM. 1730 01:04:40,920 --> 01:04:44,120 COLLEAGUES AT NIH CAN SHARE 1731 01:04:44,120 --> 01:04:45,200 OPPORTUNITIES WITH COMMUNITIES 1732 01:04:45,200 --> 01:04:46,400 AND SUPPORT PROPOSAL EVALUATION 1733 01:04:46,400 --> 01:04:47,400 WHEN PROPOSALS COME IN. 1734 01:04:47,400 --> 01:04:50,800 ALL OF MY PROGRAMS WHEN I WAS AT 1735 01:04:50,800 --> 01:04:52,120 DARPA HAD NIH SUBJECT MATTER 1736 01:04:52,120 --> 01:04:54,600 EXPERTS PROVIDING SOME REVIEWS, 1737 01:04:54,600 --> 01:04:55,720 ULTIMATELY WAS THE SINGLE 1738 01:04:55,720 --> 01:04:57,680 DECISION MAKER BUT DID WANT TO 1739 01:04:57,680 --> 01:04:58,320 HEAR PERSPECTIVES FROM EXPERTS 1740 01:04:58,320 --> 01:04:59,560 ON, YOU KNOW, WHERE IS THE STATE 1741 01:04:59,560 --> 01:05:01,280 OF THE ART, WILL THIS MAKE AN 1742 01:05:01,280 --> 01:05:02,720 IMPACT, THIS IS A REALLY 1743 01:05:02,720 --> 01:05:04,240 IMPORTANT ASPECT OF THIS. 1744 01:05:04,240 --> 01:05:07,440 FOR THOSE PROGRAMS THAT ARE NEAR 1745 01:05:07,440 --> 01:05:09,600 AND DEAR TO AN NIH I.C. AND 1746 01:05:09,600 --> 01:05:11,720 BEYOND WE WANT TO HAVE THOSE NIH 1747 01:05:11,720 --> 01:05:13,680 PLAYERS AS STAKEHOLDERS TO SEE 1748 01:05:13,680 --> 01:05:15,520 WHAT THE PROGRESS IS, AND HELP 1749 01:05:15,520 --> 01:05:16,720 ADVANCE THEIR OWN PROGRAMS ALONG 1750 01:05:16,720 --> 01:05:17,840 THE WAY, ESPECIALLY IF THEY ARE 1751 01:05:17,840 --> 01:05:19,240 GOING TO BE OUR TRANSITION 1752 01:05:19,240 --> 01:05:19,680 PARTNERS. 1753 01:05:19,680 --> 01:05:21,760 SO WE NEED TO MAKE SURE WE'RE 1754 01:05:21,760 --> 01:05:22,880 SHAPING PROGRAMS THAT CAN 1755 01:05:22,880 --> 01:05:23,840 TRANSITION AND THAT WE'RE 1756 01:05:23,840 --> 01:05:25,600 DEVELOPING SO THEY CAN RECEIVE 1757 01:05:25,600 --> 01:05:26,280 THAT LONG-TERM MAINTENANCE 1758 01:05:26,280 --> 01:05:29,120 FUNDING ON THE BACK END. 1759 01:05:29,120 --> 01:05:31,280 I DID SAY THAT I'M NOT GOING TO 1760 01:05:31,280 --> 01:05:33,040 DICTATE WHAT PROGRAMS WE'RE 1761 01:05:33,040 --> 01:05:35,240 GOING TO FUND BUT IDENTIFIED 1762 01:05:35,240 --> 01:05:37,080 INITIAL FOCUS AREAS THAT HELP 1763 01:05:37,080 --> 01:05:39,400 GIVE AN IDEA OF THE TYPES OF BIG 1764 01:05:39,400 --> 01:05:41,680 LEVERS IN HEALTH WE SEE OUT 1765 01:05:41,680 --> 01:05:42,520 THERE WITH SIGNIFICANT 1766 01:05:42,520 --> 01:05:43,400 INVESTMENT WE REALLY WILL 1767 01:05:43,400 --> 01:05:45,200 ADVANCE THE STATE OF THE ART TO 1768 01:05:45,200 --> 01:05:47,520 IMPROVE BETTER HEALTH OUTCOMES 1769 01:05:47,520 --> 01:05:48,920 FOR EVERYONE. 1770 01:05:48,920 --> 01:05:53,520 ONE IS HEALTH SCIENCE FUTURES, 1771 01:05:53,520 --> 01:05:54,720 EXPANDING WHAT'S TECHNICALLY 1772 01:05:54,720 --> 01:05:55,400 POSSIBLE. 1773 01:05:55,400 --> 01:05:59,000 WHAT DISEASES? 1774 01:05:59,000 --> 01:06:00,760 WE'RE DISEASE AGNOSTIC AND WANT 1775 01:06:00,760 --> 01:06:01,520 TOOLS, PLATFORMS AND 1776 01:06:01,520 --> 01:06:02,600 TECHNOLOGIES RELEVANT FOR A 1777 01:06:02,600 --> 01:06:03,800 NUMBER OF DISEASES. 1778 01:06:03,800 --> 01:06:07,640 IF YOU CAN IMAGINE MAYBE DIGITAL 1779 01:06:07,640 --> 01:06:10,400 HISTOPATHOLOGY, A.I. MACHINE 1780 01:06:10,400 --> 01:06:11,360 READABLE DIAGNOSTIC TOOL WOULD 1781 01:06:11,360 --> 01:06:14,040 ADVANCE STATE OF THE ART FOR 1782 01:06:14,040 --> 01:06:15,240 CANCER AND ALZHEIMER'S DISEASE, 1783 01:06:15,240 --> 01:06:19,920 SO A PROGRAM MANAGER MAY FUND 1784 01:06:19,920 --> 01:06:22,120 PROJECTS AROUND BOTH. 1785 01:06:22,120 --> 01:06:24,720 I'M GOING TO TAKE A SIP OF WATER 1786 01:06:24,720 --> 01:06:27,800 REAL QUICK. 1787 01:06:27,800 --> 01:06:29,440 SCALABLE SOLUTIONS, THESE ARE 1788 01:06:29,440 --> 01:06:31,320 MAKING SURE THAT THERE HAS BEEN 1789 01:06:31,320 --> 01:06:32,840 INVESTMENT IN SOME PLACES, MAYBE 1790 01:06:32,840 --> 01:06:34,240 THERE'S A PROOF OF CONCEPT BUT 1791 01:06:34,240 --> 01:06:35,600 WE HAVEN'T MADE SOMETHING AT 1792 01:06:35,600 --> 01:06:37,320 SCALE. 1793 01:06:37,320 --> 01:06:38,760 BY SCALE I MEAN MANUFACTURING 1794 01:06:38,760 --> 01:06:45,520 SCALE, ALSO IN TERMS OF MEETING 1795 01:06:45,520 --> 01:06:47,160 PEOPLE IN THEIR HOMES. 1796 01:06:47,160 --> 01:06:49,120 THE CUSTOMER IS THE PERSON 1797 01:06:49,120 --> 01:06:51,760 PEOPLE AND HOW DO WE REACH 1798 01:06:51,760 --> 01:06:52,120 EVERYBODY? 1799 01:06:52,120 --> 01:06:52,760 PRO-ACTIVE HEALTH, KEEPING 1800 01:06:52,760 --> 01:06:54,360 PEOPLE FROM BECOMING PATIENTS IN 1801 01:06:54,360 --> 01:06:56,360 THE FIRST PLACE. 1802 01:06:56,360 --> 01:06:58,480 SO EXTENDING YOUR HEALTH SPAN, 1803 01:06:58,480 --> 01:07:00,120 THIS CAN BE DIAGNOSTIC AND 1804 01:07:00,120 --> 01:07:01,640 DETECTION TOOLS BUT WE ALSO KNOW 1805 01:07:01,640 --> 01:07:02,960 THAT THERE'S A LOT OF 1806 01:07:02,960 --> 01:07:04,680 PREVENTIBLE DISEASES OUT THERE. 1807 01:07:04,680 --> 01:07:06,360 SO WHAT ARE INVESTMENT IN 1808 01:07:06,360 --> 01:07:08,000 BEHAVIORAL SCIENCE FOR EXAMPLE 1809 01:07:08,000 --> 01:07:09,840 THAT MAY ADVANCE PRO-ACTIVE 1810 01:07:09,840 --> 01:07:10,760 HEALTH? 1811 01:07:10,760 --> 01:07:14,080 THREE OFFICES I JUST DESCRIBED, 1812 01:07:14,080 --> 01:07:18,240 IF YOU LIKE TO STUDY PNS 1813 01:07:18,240 --> 01:07:20,360 INNOVATION, P PRODUCT IS REALLY 1814 01:07:20,360 --> 01:07:21,760 ON THE LEFT-HAND SIDE, 1815 01:07:21,760 --> 01:07:27,120 DEVELOPING THE TOOLS THAT 1816 01:07:27,120 --> 01:07:28,520 SYSTEMS LEVEL, S-TYPE, BUILDING 1817 01:07:28,520 --> 01:07:29,440 INTEGRATED HEALTH CARE SYSTEMS. 1818 01:07:29,440 --> 01:07:30,720 THROUGH THE LAST THREE YEARS WE 1819 01:07:30,720 --> 01:07:32,600 DO NOT HAVE A RESILIENT HEALTH 1820 01:07:32,600 --> 01:07:34,360 CARE SYSTEMS IN THE UNITED 1821 01:07:34,360 --> 01:07:37,080 STATES, WE CAN IMPROVE, HOW DO 1822 01:07:37,080 --> 01:07:39,520 WE CREATE SYSTEMS THAT CAN WITH 1823 01:07:39,520 --> 01:07:41,480 STAND CRISES LIKE PANDEMICS, 1824 01:07:41,480 --> 01:07:43,440 SOCIAL DISRUPTION, CLIMATE 1825 01:07:43,440 --> 01:07:44,640 CHANGE, ECONOMIC INSTABILITY, 1826 01:07:44,640 --> 01:07:46,200 WHAT ARE INVESTMENTS THAT MAYBE 1827 01:07:46,200 --> 01:07:48,040 TAKE INNOVATION THAT'S ALREADY 1828 01:07:48,040 --> 01:07:49,560 OUT THERE BUT WHAT'S MISSING IS 1829 01:07:49,560 --> 01:07:51,960 DIGITAL LAYER THAT BRINGS THOSE 1830 01:07:51,960 --> 01:07:53,960 ALL TOGETHER, A SINGLE STANDARD 1831 01:07:53,960 --> 01:07:55,040 FOR A DASHBOARD THAT REPORTS 1832 01:07:55,040 --> 01:07:57,040 THAT INFORMATION. 1833 01:07:57,040 --> 01:07:59,640 I KNOW I'M PREACHING TO THE 1834 01:07:59,640 --> 01:08:00,920 CHOIR IN THE NIAID INFECTIOUS 1835 01:08:00,920 --> 01:08:05,200 DISEASE COMMUNITY THAT A LOT OF 1836 01:08:05,200 --> 01:08:06,120 THESE STANDARDS AND 1837 01:08:06,120 --> 01:08:08,360 COMMUNICATING INFORMATION DON'T 1838 01:08:08,360 --> 01:08:08,800 EXIST. 1839 01:08:08,800 --> 01:08:10,440 WE SHARED THIS, LUCKY ENOUGH TO 1840 01:08:10,440 --> 01:08:12,760 BE INVITED BY NIH COLLEAGUES TO 1841 01:08:12,760 --> 01:08:14,280 PARTICIPATE IN THE GATES 1842 01:08:14,280 --> 01:08:16,240 FOUNDATION WORKSHOP THINKING 1843 01:08:16,240 --> 01:08:19,440 ABOUT GLOBAL HEALTH, SOME 1844 01:08:19,440 --> 01:08:23,840 EXAMPLES ARE IMAGINE IF WE COULD 1845 01:08:23,840 --> 01:08:24,680 CREATE SOME PROGRAMMABLE 1846 01:08:24,680 --> 01:08:26,560 THERAPIES, COMMON GENE 1847 01:08:26,560 --> 01:08:28,080 MODULATION TOOL TO TREAT 1848 01:08:28,080 --> 01:08:30,840 MULTIPLE DISEASES INCLUDING RARE 1849 01:08:30,840 --> 01:08:31,440 DISEASES? 1850 01:08:31,440 --> 01:08:35,200 SO THINKING LIKE A Cas9 TO 1851 01:08:35,200 --> 01:08:38,720 KNOCK DOWN ACE-2 RECEPTION TO 1852 01:08:38,720 --> 01:08:41,960 PREVENT SARS-COV-2 INFECTION IN 1853 01:08:41,960 --> 01:08:42,960 LUNGS. 1854 01:08:42,960 --> 01:08:45,160 SCALABLE SOLUTIONS, CHALLENGES 1855 01:08:45,160 --> 01:08:48,200 THAT DON'T REQUIRE COLD STORAGE 1856 01:08:48,200 --> 01:08:49,560 OR NEEDLES, WE JUST USE POSTAL 1857 01:08:49,560 --> 01:08:51,400 SERVICE TO DELIVER TESTS. 1858 01:08:51,400 --> 01:08:52,200 WHAT ABOUT VACCINES? 1859 01:08:52,200 --> 01:08:55,320 WHAT DOES IT LOOK LIKE TO 1860 01:08:55,320 --> 01:08:58,400 ACHIEVE THAT? 1861 01:08:58,400 --> 01:09:01,320 I GAVE THE EXAMPLE OF 3D 1862 01:09:01,320 --> 01:09:01,680 HISTOPATHOLOGY. 1863 01:09:01,680 --> 01:09:03,360 THE TYPES OF PROGRAMS THAT WE 1864 01:09:03,360 --> 01:09:05,000 MIGHT EXPECT, THESE ARE THE 1865 01:09:05,000 --> 01:09:06,600 PROGRAM MANAGERS WE WANT TO 1866 01:09:06,600 --> 01:09:07,160 RECRUIT. 1867 01:09:07,160 --> 01:09:10,400 MY BIG REQUEST FOR THIS GROUP 1868 01:09:10,400 --> 01:09:11,840 RIGHT NOW IS I CAN'T SPEND THE 1869 01:09:11,840 --> 01:09:14,800 MONEY THAT I'VE BEEN GIVEN BY 1870 01:09:14,800 --> 01:09:16,160 THE CONGRESS UNTIL I HAVE 1871 01:09:16,160 --> 01:09:17,960 PROGRAM MANAGERS ON BOARD THAT 1872 01:09:17,960 --> 01:09:19,640 ARE ABLE TO DEFINE THE PROBLEM 1873 01:09:19,640 --> 01:09:20,960 THEY WANT TO SOLVE AND LAUNCH 1874 01:09:20,960 --> 01:09:24,000 THOSE INTO THE FUTURE. 1875 01:09:24,000 --> 01:09:25,200 MAYBE THERE'S MEMBERS ON THE 1876 01:09:25,200 --> 01:09:26,960 LINE NOW THAT WANT TO BECOME 1877 01:09:26,960 --> 01:09:28,840 PROGRAM MANAGERS OR MAYBE YOU 1878 01:09:28,840 --> 01:09:30,040 KNOW SOMEBODY IN YOUR NETWORK. 1879 01:09:30,040 --> 01:09:31,880 PLEASE THINK ABOUT THE FOLKS 1880 01:09:31,880 --> 01:09:33,680 THAT WANT TO CHANGE THE 1881 01:09:33,680 --> 01:09:35,440 DIRECTION IN THEIR FIELD, 1882 01:09:35,440 --> 01:09:36,480 PASSIONATE ABOUT SOLVING THEIR 1883 01:09:36,480 --> 01:09:38,400 PROBLEM, WILLING TO COME ON FOR 1884 01:09:38,400 --> 01:09:40,320 A TERM APPOINTMENT, BASE OF 1885 01:09:40,320 --> 01:09:41,760 THREE YEARS, RENEWABLE UP TO 1886 01:09:41,760 --> 01:09:42,440 SIX. 1887 01:09:42,440 --> 01:09:44,400 WE CAN OFFER A COMPETITIVE 1888 01:09:44,400 --> 01:09:45,240 SALARY. 1889 01:09:45,240 --> 01:09:46,920 SO I'M VERY LUCKY I HAVE DIRECT 1890 01:09:46,920 --> 01:09:47,680 HIRING AUTHORITY THAT'S BEEN 1891 01:09:47,680 --> 01:09:49,640 GIVEN TO ME BY THE CONGRESS SO 1892 01:09:49,640 --> 01:09:50,880 IF WE IDENTIFY GREAT CANDIDATE I 1893 01:09:50,880 --> 01:09:52,360 CAN HIRE THEM NEXT WEEK. 1894 01:09:52,360 --> 01:09:55,360 THERE'S NOT A VERY LONG JOB 1895 01:09:55,360 --> 01:09:55,800 APPLICATION PROCESS. 1896 01:09:55,800 --> 01:09:58,400 AND WE CAN HIRE UP TO THE 1897 01:09:58,400 --> 01:10:00,040 PRESIDENT'S SALARY, OUTSIDE OF 1898 01:10:00,040 --> 01:10:01,920 THE GS SCALE, ATTRACTIVE TO MANY 1899 01:10:01,920 --> 01:10:02,760 FOLKS IN INDUSTRY. 1900 01:10:02,760 --> 01:10:06,280 WE HAVE A COMMITMENT OF COURSE 1901 01:10:06,280 --> 01:10:07,680 TO DIVERSITY, IN GEOGRAPHY AND 1902 01:10:07,680 --> 01:10:10,760 DEMOGRAPHICS AND EXPERIENCE. 1903 01:10:10,760 --> 01:10:12,080 SO GOVERNMENT, INDUSTRY, 1904 01:10:12,080 --> 01:10:13,760 ACADEMIA AND THE TOPICS, WE WANT 1905 01:10:13,760 --> 01:10:15,080 A DIVERSITY OF TOPICS ESPECIALLY 1906 01:10:15,080 --> 01:10:16,920 AS WE LAUNCH THIS ORGANIZATION 1907 01:10:16,920 --> 01:10:20,000 SO WE CAN SHOW JUST THE SPECTRUM 1908 01:10:20,000 --> 01:10:23,160 AND CONTINUUM OF WORK ARPA-H CAN 1909 01:10:23,160 --> 01:10:24,480 REALLY FACILITATE GOING FORWARD. 1910 01:10:24,480 --> 01:10:26,000 KNOW THAT PERSON IS JOINING A 1911 01:10:26,000 --> 01:10:27,560 TEAM, THEY ARE NOT MEANT TO 1912 01:10:27,560 --> 01:10:29,080 CHANGE THE DIRECTION OF THEIR 1913 01:10:29,080 --> 01:10:30,880 FIELD ALONE. 1914 01:10:30,880 --> 01:10:33,120 WE HAVE THIS ENTIRE BUSINESS 1915 01:10:33,120 --> 01:10:35,040 TEAM ALSO VISIONARIES AND 1916 01:10:35,040 --> 01:10:36,080 INNOVATORS FINDING THE RIGHT 1917 01:10:36,080 --> 01:10:38,840 WAYS TO DO CONTRACTING TO REALLY 1918 01:10:38,840 --> 01:10:40,240 ACHIEVE THOSE GOALS, FOR 1919 01:10:40,240 --> 01:10:42,880 EXAMPLE, AND ALSO HAVING A TEAM 1920 01:10:42,880 --> 01:10:43,640 TYPICALLY EACH PROGRAM MANAGER 1921 01:10:43,640 --> 01:10:46,440 WILL HAVE A TEACH OF CONTRACTORS 1922 01:10:46,440 --> 01:10:49,520 THEY CAN HIRE THAT ARE SUBJECT 1923 01:10:49,520 --> 01:10:51,680 MATTER EXPERTS TO HELP THEM RUN 1924 01:10:51,680 --> 01:10:53,240 THE DAY-TO-DAY OF THE PROGRAMS. 1925 01:10:53,240 --> 01:10:55,760 PROGRAM MANAGERS, THEY HAVE THIS 1926 01:10:55,760 --> 01:10:56,840 SERIOUS DRIVE, VERY PASSIONATE 1927 01:10:56,840 --> 01:10:58,160 ABOUT SOLVING THEIR PROBLEM BUT 1928 01:10:58,160 --> 01:11:01,000 NOT AFRAID TO FAIL AND THEY ARE 1929 01:11:01,000 --> 01:11:01,480 VERY TECHNICALLY HONEST. 1930 01:11:01,480 --> 01:11:02,880 THEY CAN SAY YOU KNOW WHAT? 1931 01:11:02,880 --> 01:11:03,840 THIS ISN'T WORKING. 1932 01:11:03,840 --> 01:11:06,480 AND WE'RE NOT GOING TO KEEP JUST 1933 01:11:06,480 --> 01:11:07,600 BRUTE FORCING THIS CHALLENGE. 1934 01:11:07,600 --> 01:11:10,280 WE NEED TO FIND ANOTHER WAY. 1935 01:11:10,280 --> 01:11:13,280 SO THE FOLKS WILLING TO TAKE 1936 01:11:13,280 --> 01:11:14,000 THOSE HARD CONVERSATIONS ARE 1937 01:11:14,000 --> 01:11:14,560 REALLY IMPORTANT. 1938 01:11:14,560 --> 01:11:17,960 THEY CAN BE AT ANY STAGE, EARLY 1939 01:11:17,960 --> 01:11:19,840 STAGE CAREER, UNBIASED, LOOKING 1940 01:11:19,840 --> 01:11:21,480 WITH FRESH EYES, VISIONARY, OR 1941 01:11:21,480 --> 01:11:22,680 MAYBE MID-CAREER, STATUS QUO AND 1942 01:11:22,680 --> 01:11:24,400 THERE'S A BLOCKER IN THEIR FIELD 1943 01:11:24,400 --> 01:11:27,360 THEY CAN'T GET PAST AND WANT TO 1944 01:11:27,360 --> 01:11:28,800 JUMP IN TO ARPA-H FOR A FEW 1945 01:11:28,800 --> 01:11:30,440 YEARS AND UNSTICK THAT IN THEIR 1946 01:11:30,440 --> 01:11:31,760 FIELD AND BE A BENEFICIARY OF 1947 01:11:31,760 --> 01:11:33,080 THAT WHEN THEY COME BACK TO IT 1948 01:11:33,080 --> 01:11:34,480 ON THE OTHER SIDE. 1949 01:11:34,480 --> 01:11:35,800 SO, WE SEE ARPA-H AS AN 1950 01:11:35,800 --> 01:11:36,880 ORGANIZATION THAT WILL HELP 1951 01:11:36,880 --> 01:11:39,400 THESE FOLKS LEVEL UP, NOT ONLY 1952 01:11:39,400 --> 01:11:41,480 THEIR FIELD BUT THEMSELVES IN 1953 01:11:41,480 --> 01:11:42,560 THEIR CAREER. 1954 01:11:42,560 --> 01:11:45,760 AGAIN, SUCCESS FOR US IS WHEN 1955 01:11:45,760 --> 01:11:47,720 SOMETHING CAN ACTUALLY SURVIVE 1956 01:11:47,720 --> 01:11:49,480 IN THE REAL WORLD, AND WE 1957 01:11:49,480 --> 01:11:50,560 BELIEVE THAT RESEARCH GRANTS 1958 01:11:50,560 --> 01:11:52,720 AREN'T THE BEST WAY TO DO THAT, 1959 01:11:52,720 --> 01:11:55,040 REALLY USING CONTRACTING 1960 01:11:55,040 --> 01:11:55,600 VEHICLES LIKE COOPERATIVE 1961 01:11:55,600 --> 01:11:57,560 AGREEMENTS, DIRECT CONTRACTS AND 1962 01:11:57,560 --> 01:11:58,320 OTHER TRANSACTIONAL AUTHORITIES 1963 01:11:58,320 --> 01:12:02,360 WILL BE THE WAY THAT WE MOVE 1964 01:12:02,360 --> 01:12:07,200 FORWARD IN OUR ORGANIZATION. 1965 01:12:07,200 --> 01:12:10,720 THE LAST IS THE PROJECT 1966 01:12:10,720 --> 01:12:11,520 ACCELERATORS OFFICE, PATIO, OUR 1967 01:12:11,520 --> 01:12:13,880 THEME IS GOING TO BE SETTING UP 1968 01:12:13,880 --> 01:12:15,280 THOSE EARLY MARKET ASSESSMENTS 1969 01:12:15,280 --> 01:12:16,840 MAKING SURE WE'RE USING 1970 01:12:16,840 --> 01:12:17,680 HUMAN-CENTRIC DESIGN IN OUR 1971 01:12:17,680 --> 01:12:19,800 PROCESSES IF WE'RE GOING TO MAKE 1972 01:12:19,800 --> 01:12:21,200 A SOFTWARE TOOL SO SOMEBODY 1973 01:12:21,200 --> 01:12:24,800 WANTS TO USE IT AND IT'S 1974 01:12:24,800 --> 01:12:25,120 INTUITIVE. 1975 01:12:25,120 --> 01:12:26,680 HELP DEVELOP BAAs, MAKING SURE 1976 01:12:26,680 --> 01:12:27,640 WE'RE ADDRESSING ALL THE RIGHT 1977 01:12:27,640 --> 01:12:30,160 COMMUNITIES THAT NEED TO BE 1978 01:12:30,160 --> 01:12:32,120 RESPONDING TO A PROGRAM AND THEN 1979 01:12:32,120 --> 01:12:33,680 EARLY ON UNDERSTANDING WHAT IS 1980 01:12:33,680 --> 01:12:35,480 THE INVESTMENT IN THE TRANSITION 1981 01:12:35,480 --> 01:12:37,720 COMMUNITY SEEING AS A RISK, MAKE 1982 01:12:37,720 --> 01:12:41,000 SURE WE'RE DE-RISKING THOSE 1983 01:12:41,000 --> 01:12:43,760 PARTS, TECHNICAL AND OTHER 1984 01:12:43,760 --> 01:12:45,400 RISKS. 1985 01:12:45,400 --> 01:12:46,680 IN TERMS OF MANAGEMENT TEAM WE 1986 01:12:46,680 --> 01:12:47,640 MAY BE ESTABLISHING, MEANT TO 1987 01:12:47,640 --> 01:12:49,520 ADDRESS ALL OF THAT BECAUSE WE 1988 01:12:49,520 --> 01:12:50,640 WANT SOLUTIONS TO SURVIVE IN THE 1989 01:12:50,640 --> 01:12:52,040 WILD SO GOVERNMENT AND OTHERS 1990 01:12:52,040 --> 01:12:54,280 CAN ULTIMATELY BE A CUSTOMER. 1991 01:12:54,280 --> 01:12:56,880 I JUST STARTED IN OCTOBER SO 1992 01:12:56,880 --> 01:12:58,400 WE'RE REALLY A START-UP. 1993 01:12:58,400 --> 01:12:59,920 LITERALLY JUST LAUNCHED A 1994 01:12:59,920 --> 01:13:03,680 WEBSITE ABOUT A MONTH AGO. 1995 01:13:03,680 --> 01:13:09,480 SO, PLEASE CHECK OUT ARPA-H.GOV, 1996 01:13:09,480 --> 01:13:10,920 FIND THE PROGRAM MANAGER LANDING 1997 01:13:10,920 --> 01:13:12,200 PAGE AND TECHNICAL AREAS I 1998 01:13:12,200 --> 01:13:13,200 MENTIONED. 1999 01:13:13,200 --> 01:13:19,800 WE HAVE A ROBUST PM PIPELINE BUT 2000 01:13:19,800 --> 01:13:22,400 NARROWING DOWN THE FUNNEL OF 2001 01:13:22,400 --> 01:13:23,160 CANDIDATES IS HARD. 2002 01:13:23,160 --> 01:13:24,360 WE'RE GOING TO BRING IN THE 2003 01:13:24,360 --> 01:13:26,880 FIRST P.M.s THIS QUARTER, WE 2004 01:13:26,880 --> 01:13:27,760 SHOULD HAVE PROGRAMS LAUNCHING 2005 01:13:27,760 --> 01:13:29,200 IN THE SECOND AND THIRD QUARTERS 2006 01:13:29,200 --> 01:13:30,720 OF THIS YEAR. 2007 01:13:30,720 --> 01:13:33,760 WE HEARD ABOUT CONGRESS IN THE 2008 01:13:33,760 --> 01:13:34,560 LAST PRESENTATION, AND SO WHAT I 2009 01:13:34,560 --> 01:13:36,400 SPENT A LOT OF TIME BEFORE THE 2010 01:13:36,400 --> 01:13:37,800 END OF LAST YEAR WAS MEETING 2011 01:13:37,800 --> 01:13:39,680 WITH OVER 30 MEMBERS OF CONGRESS 2012 01:13:39,680 --> 01:13:41,760 TO REALLY LOCK IN OUR 2013 01:13:41,760 --> 01:13:43,840 AUTHORITIES IN THE OMNIBUS WHICH 2014 01:13:43,840 --> 01:13:46,280 I'M PLEASED TO SAY THAT WE WERE 2015 01:13:46,280 --> 01:13:47,360 SUCCESSFUL WITH AND WE'RE 2016 01:13:47,360 --> 01:13:48,680 STARTING TO NOW ENGAGE 2017 01:13:48,680 --> 01:13:49,760 UNIVERSITIES AND THOSE PATIENT 2018 01:13:49,760 --> 01:13:52,320 ADVOCACY GROUPS THAT ARE GOING 2019 01:13:52,320 --> 01:13:53,960 TO BE NOT JUST PERFORMERS BUT 2020 01:13:53,960 --> 01:13:55,440 MAIN BENEFICIARIES FOR US. 2021 01:13:55,440 --> 01:13:58,200 WE LOVE WORKING TOGETHER WITH 2022 01:13:58,200 --> 01:14:04,000 NIH. 2023 01:14:04,000 --> 01:14:04,640 HERE IS TARA SCHWETZ 2024 01:14:04,640 --> 01:14:05,960 THEY CAME TO OUR LAUNCH AT 2025 01:14:05,960 --> 01:14:07,040 HOWARD UNIVERSITY. 2026 01:14:07,040 --> 01:14:08,640 WE WANT TO ENGAGE MINORITY 2027 01:14:08,640 --> 01:14:09,920 COMMUNITIES AND SO IT WAS 2028 01:14:09,920 --> 01:14:11,400 IMPORTANT TO LAUNCH AND MAKE 2029 01:14:11,400 --> 01:14:14,040 SURE WE GET PROGRAM MANAGERS AND 2030 01:14:14,040 --> 01:14:14,360 PERFORMERS. 2031 01:14:14,360 --> 01:14:18,560 WE'RE MEETING WITH I.T. 2032 01:14:18,560 --> 01:14:19,800 DIRECTORS TO, STARTED SMALLER 2033 01:14:19,800 --> 01:14:22,400 BRAINSTORMING SESSIONS WHAT ARE 2034 01:14:22,400 --> 01:14:25,800 SOME CONCEPTES WE COULD PURSUE. 2035 01:14:25,800 --> 01:14:28,320 WE'VE BEEN VERY LUCKY TO HAVE AN 2036 01:14:28,320 --> 01:14:30,280 OPEN DOOR WITH NIH AS WE START 2037 01:14:30,280 --> 01:14:33,160 TO LAUNCH AND WORK TOGETHER. 2038 01:14:33,160 --> 01:14:35,160 I'LL LEAVE WITH THIS CALL TO 2039 01:14:35,160 --> 01:14:38,200 ACTION, HAPPY IF THERE'S TIME TO 2040 01:14:38,200 --> 01:14:40,080 TAKE ANY QUESTIONS. 2041 01:14:40,080 --> 01:14:41,480 AGAIN, PROGRAM MANAGERS ARE OUR 2042 01:14:41,480 --> 01:14:42,920 TOP PRIORITY THAT WE'RE HIRING 2043 01:14:42,920 --> 01:14:46,080 SO PLEASE EITHER CONSIDER THAT 2044 01:14:46,080 --> 01:14:50,000 YOURSELF OR SEND THOSE UNICORNS 2045 01:14:50,000 --> 01:14:52,440 OF GREAT CV PLUS BIG PROBLEMS 2046 01:14:52,440 --> 01:14:53,840 THEY WANT TO SOLVE, SEND THOSE 2047 01:14:53,840 --> 01:14:55,800 FOLKS OUR WAY. 2048 01:14:55,800 --> 01:14:57,800 THANKS AGAIN FOR INVITING ME. 2049 01:14:57,800 --> 01:14:59,640 >>RENEE, A GREAT PRESENTATION. 2050 01:14:59,640 --> 01:15:00,840 I'VE HEARD PORTIONS BEFORE, I 2051 01:15:00,840 --> 01:15:03,600 THINK IT GETS BETTER EACH TIME. 2052 01:15:03,600 --> 01:15:05,680 ONE QUESTION FROM ME AND LET'S 2053 01:15:05,680 --> 01:15:08,000 OPEN IT UP. 2054 01:15:08,000 --> 01:15:09,480 I'VE SEEN A NUMBER OF PLACES 2055 01:15:09,480 --> 01:15:12,240 SUGGEST YOU SHOULDN'T GO TO NIH 2056 01:15:12,240 --> 01:15:14,000 EMPLOYEES TO FIND YOUR PROGRAM 2057 01:15:14,000 --> 01:15:14,360 MANAGERS. 2058 01:15:14,360 --> 01:15:19,680 HOW STRONGLY DO YOU FEEL THAT 2059 01:15:19,680 --> 01:15:20,080 WAY? 2060 01:15:20,080 --> 01:15:21,760 >>WELL, I'LL TELL YOU HOW 2061 01:15:21,760 --> 01:15:23,960 STRONGLY CONGRESS FEELS ABOUT 2062 01:15:23,960 --> 01:15:24,360 IT. 2063 01:15:24,360 --> 01:15:27,680 IN THE OMNIBUS THEY HAVE CREATED 2064 01:15:27,680 --> 01:15:29,200 A RESTRICTION THAT THE -- 2065 01:15:29,200 --> 01:15:30,560 ANYBODY WHO WORKED AT NIH IN THE 2066 01:15:30,560 --> 01:15:34,160 LAST THREE YEARS NEEDS TO 2067 01:15:34,160 --> 01:15:35,800 RECEIVE A WAIVER TO AN ARPA-H 2068 01:15:35,800 --> 01:15:37,880 EMPLOYEE, IT'S NOT JUST PROGRAM 2069 01:15:37,880 --> 01:15:40,080 MANAGERS, IT'S ACROSS THE BOARD. 2070 01:15:40,080 --> 01:15:41,480 I WILL EMPLOY THE WAIVER IF I 2071 01:15:41,480 --> 01:15:44,040 NEED TO BECAUSE I WOULD HOPE I 2072 01:15:44,040 --> 01:15:47,840 SHOULD BE TRUSTED TO HIRE THE 2073 01:15:47,840 --> 01:15:49,360 BEST AND BRIGHTEST, BUT 2074 01:15:49,360 --> 01:15:50,720 CERTAINLY INCLUDING FOLKS THAT 2075 01:15:50,720 --> 01:15:52,640 MAY BE AT NIH. 2076 01:15:52,640 --> 01:15:56,040 SO WE ARE OPEN TO IT BUT THAT IS 2077 01:15:56,040 --> 01:15:57,160 INDEED THE RESTRICTION IN PLACE 2078 01:15:57,160 --> 01:15:58,160 AT THE MOMENT. 2079 01:15:58,160 --> 01:15:59,440 >>GOT IT. 2080 01:15:59,440 --> 01:16:04,840 KEITH JEROME WAS THE FIRST HAND 2081 01:16:04,840 --> 01:16:05,200 I SAW. 2082 01:16:05,200 --> 01:16:08,440 >>YEAH, UNIVERSITY OF 2083 01:16:08,440 --> 01:16:11,600 WASHINGTON, SEATTLE, YOUR 2084 01:16:11,600 --> 01:16:22,040 DISCUSSION HOW THE HALMIRE 2085 01:16:25,120 --> 01:16:26,960 FRAMEWORK, THE STAGE AND 2086 01:16:26,960 --> 01:16:30,320 MATURITY OF IDEAS THIS IS REALLY 2087 01:16:30,320 --> 01:16:33,760 BUILT TO MOVE FORWARD, THE 2088 01:16:33,760 --> 01:16:35,400 NATURAL TENSION BETWEEN THINGS 2089 01:16:35,400 --> 01:16:41,120 TOO MATURE VERSUS WHAT MAY BE 2090 01:16:41,120 --> 01:16:41,640 GROUNDBREAKING. 2091 01:16:41,640 --> 01:16:43,360 >>I APPRECIATE THE QUESTION. 2092 01:16:43,360 --> 01:16:46,080 WHEN THE TECHNOLOGY READINESS 2093 01:16:46,080 --> 01:16:47,720 LEVEL, FROM ONE BEING NEVER 2094 01:16:47,720 --> 01:16:49,200 SHOWN BEFORE PROOF OF CONCEPT TO 2095 01:16:49,200 --> 01:16:52,240 NINE BEING SOMETHING YOU CAN BUY 2096 01:16:52,240 --> 01:16:55,520 OFF THE SHELF AT CVS, WE'RE 2097 01:16:55,520 --> 01:16:57,840 GOING TO FOCUS ON ONE THROUGH 2098 01:16:57,840 --> 01:16:59,040 FIVE, WITH SYSTEMS INTEGRATION, 2099 01:16:59,040 --> 01:17:00,520 WE'LL LOOK AT SOME OF THOSE 2100 01:17:00,520 --> 01:17:01,760 PROOFS OF CONCEPTS WHERE THINGS 2101 01:17:01,760 --> 01:17:05,960 NEED TO BE PULLED TOGETHER, AND 2102 01:17:05,960 --> 01:17:06,840 SYSTEM INTEGRATION. 2103 01:17:06,840 --> 01:17:08,360 WE'LL EXPLORE THE RANGE BUT TO 2104 01:17:08,360 --> 01:17:10,200 THE POINT ABOUT A PUBLICATION WE 2105 01:17:10,200 --> 01:17:11,520 DON'T NEED TO SEE PROOF THAT 2106 01:17:11,520 --> 01:17:12,480 SOMETHING WORKS. 2107 01:17:12,480 --> 01:17:14,280 WE NEED TO SEE PROOF IN APPROACH 2108 01:17:14,280 --> 01:17:16,080 BUT WHAT WE WANT TO SEE FROM 2109 01:17:16,080 --> 01:17:17,960 PROGRAM MANAGERS IS THEY REALLY 2110 01:17:17,960 --> 01:17:19,720 THOUGHT THROUGH LIKE HOW CAN 2111 01:17:19,720 --> 01:17:21,680 THEY BE SUCCESSFUL THAT THERE'S 2112 01:17:21,680 --> 01:17:24,080 SIGNALS OUT THERE, MAYBE IT'S A 2113 01:17:24,080 --> 01:17:26,600 PATENT, BUT MAYBE IT'S NOT. 2114 01:17:26,600 --> 01:17:29,920 MAYBE THEY JUST HAVE THIS EUREKA 2115 01:17:29,920 --> 01:17:30,640 MOMENT PUTTING THINGS TOGETHER 2116 01:17:30,640 --> 01:17:31,880 THEY WILL BE ABLE TO SOLVE THIS 2117 01:17:31,880 --> 01:17:33,960 PROBLEM BUT WE WANT THEM TO WALK 2118 01:17:33,960 --> 01:17:35,080 US THROUGH THEIR LOGIC. 2119 01:17:35,080 --> 01:17:37,760 THERE'S A TON OF GREAT IDEAS OUT 2120 01:17:37,760 --> 01:17:38,160 THERE. 2121 01:17:38,160 --> 01:17:40,080 LOTS OF LACK OF EXECUTION. 2122 01:17:40,080 --> 01:17:41,520 SO IT'S REALLY AN EXECUTION 2123 01:17:41,520 --> 01:17:42,800 THERE'S GOING TO BE -- THAT 2124 01:17:42,800 --> 01:17:49,920 WE'RE GETTING IT'S A IN THAT 2125 01:17:49,920 --> 01:17:56,280 NUMBER THREE. 2126 01:17:56,280 --> 01:18:04,520 >>RITU AGRAWAL. 2127 01:18:04,520 --> 01:18:06,360 >>YOU MENTIONED YOU WON'T HAVE 2128 01:18:06,360 --> 01:18:08,440 STANDARD STUDY SECTIONS AND 2129 01:18:08,440 --> 01:18:10,520 INDICATED YOU MAY CALL UPON SOME 2130 01:18:10,520 --> 01:18:11,280 SUBJECT NIH SUBJECT MATTERS 2131 01:18:11,280 --> 01:18:12,600 EXPERTS TO COMMENT ON PROPOSALS 2132 01:18:12,600 --> 01:18:15,560 YOU GET OR PROGRAM MANAGERS 2133 01:18:15,560 --> 01:18:15,800 GENERATE. 2134 01:18:15,800 --> 01:18:17,520 MY QUESTION IS, YOU KNOW, HAVE 2135 01:18:17,520 --> 01:18:20,280 YOU THOUGHT THROUGH WHAT THIS 2136 01:18:20,280 --> 01:18:22,440 NEW PEER REVIEW PROCESS MIGHT 2137 01:18:22,440 --> 01:18:23,840 LOOK LIKE, IF YOU COULD SAY 2138 01:18:23,840 --> 01:18:25,200 SOMETHING ABOUT THAT? 2139 01:18:25,200 --> 01:18:27,640 THE SECOND QUESTION RELATES TO 2140 01:18:27,640 --> 01:18:29,840 KEITH'S POINT, ALONG THE 2141 01:18:29,840 --> 01:18:38,480 CONTINUUM OF BASIC DISCOVERY, 2142 01:18:38,480 --> 01:18:39,240 TWO THINGS IMMEDIATELY 2143 01:18:39,240 --> 01:18:40,120 COMMERCIALIZABLE, YOU MENTIONED 2144 01:18:40,120 --> 01:18:41,760 THESE ARE NOT RESEARCH GRANTS SO 2145 01:18:41,760 --> 01:18:46,000 IF YOU COULD SPEAK A LITTLE BIT 2146 01:18:46,000 --> 01:18:46,240 TO THAT. 2147 01:18:46,240 --> 01:18:48,960 >>YES, FIRST ON THE PEER 2148 01:18:48,960 --> 01:18:51,480 REVIEW, IT'S NOT A NEW PROCESS. 2149 01:18:51,480 --> 01:18:55,000 WE'RE ADOPTING THE PROCESS USED 2150 01:18:55,000 --> 01:18:55,240 BY DARPA. 2151 01:18:55,240 --> 01:18:55,520 >>OKAY. 2152 01:18:55,520 --> 01:19:01,800 >>SO THE WAY THAT WORKS IS 2153 01:19:01,800 --> 01:19:03,280 WE'LL IDENTIFY EXPERTS THAT CAN 2154 01:19:03,280 --> 01:19:04,960 WEIGH IN ON THE PROGRAM, AND SO 2155 01:19:04,960 --> 01:19:06,040 WHETHER THOSE ARE FROM 2156 01:19:06,040 --> 01:19:08,360 GOVERNMENT OR INDUSTRY THEY WILL 2157 01:19:08,360 --> 01:19:09,920 GO THROUGH ETHICS, LIKE YOU 2158 01:19:09,920 --> 01:19:13,400 WOULD FOR ANY OTHER REVIEW. 2159 01:19:13,400 --> 01:19:15,360 AND WE'LL SET EVALUATION 2160 01:19:15,360 --> 01:19:15,800 CRITERIA. 2161 01:19:15,800 --> 01:19:22,160 SO TYPICALLY THOSE ARE, YOU 2162 01:19:22,160 --> 01:19:23,360 KNOW, IS THIS TECHNICALLY 2163 01:19:23,360 --> 01:19:24,400 POSSIBLE, WHAT ABOUT COST 2164 01:19:24,400 --> 01:19:24,880 REALISM? 2165 01:19:24,880 --> 01:19:26,480 WE'RE NOT TRYING TO NICKEL AND 2166 01:19:26,480 --> 01:19:27,920 DIME THE PROJECT BUT HAVE THEY 2167 01:19:27,920 --> 01:19:29,600 PROPOSED ENOUGH FUNDS TO ACHIEVE 2168 01:19:29,600 --> 01:19:30,680 THAT THEY SAY THEY WANT TO DO 2169 01:19:30,680 --> 01:19:32,520 AND IS THIS JUSTIFIED? 2170 01:19:32,520 --> 01:19:34,960 THE OTHER CRITERIA IS REALLY 2171 01:19:34,960 --> 01:19:36,360 LOOKING AT THE TEAM THEY HAVE IN 2172 01:19:36,360 --> 01:19:36,800 PLACE. 2173 01:19:36,800 --> 01:19:39,200 DO WE HAVE -- ARE THE RIGHT 2174 01:19:39,200 --> 01:19:40,320 EXPERTS HERE, PROGRAM MANAGER 2175 01:19:40,320 --> 01:19:41,520 MAY ADD OTHERS. 2176 01:19:41,520 --> 01:19:43,040 WE ASK FOR THOSE REVIEWERS WE 2177 01:19:43,040 --> 01:19:44,360 INVITE FROM NIH AND OTHER PLACES 2178 01:19:44,360 --> 01:19:45,720 TO WEIGH IN. 2179 01:19:45,720 --> 01:19:47,240 THE PROGRAM MANAGER WILL TAKE 2180 01:19:47,240 --> 01:19:48,960 THOSE INSIGHTS IN THEIR FINAL 2181 01:19:48,960 --> 01:19:50,520 DECISION BUT AGAIN THE PROGRAM 2182 01:19:50,520 --> 01:19:52,000 MANAGER MAKES A DECISION. 2183 01:19:52,000 --> 01:19:53,800 THEY MAY DISAGREE WITH 2184 01:19:53,800 --> 01:19:54,840 REVIEWERS, COMPLETELY FINE. 2185 01:19:54,840 --> 01:20:02,040 AND SO THEY SHOULD JUSTIFY, WHY 2186 01:20:02,040 --> 01:20:03,840 THEY DISSENT, WHAT THE REVIEWER 2187 01:20:03,840 --> 01:20:05,480 SAYS BUT IT'S THEIR DECISION SO 2188 01:20:05,480 --> 01:20:13,400 THEY CAN TAKE THOSE RISKS. 2189 01:20:13,400 --> 01:20:14,480 [AUDIO DISTORTION] 2190 01:20:14,480 --> 01:20:18,840 FOR THE FUNDING WE HAVE HAVEN'T 2191 01:20:18,840 --> 01:20:20,360 ALLOCATED -- LOOKS LIKE I'M 2192 01:20:20,360 --> 01:20:21,280 HAVING AN UNSTABLE INTERNET 2193 01:20:21,280 --> 01:20:24,360 MESSAGE HERE. 2194 01:20:24,360 --> 01:20:26,320 THE FUNDS, THE PROGRAMS, THERE'S 2195 01:20:26,320 --> 01:20:28,720 A SMALL OPERATING BUDGET WE NEED 2196 01:20:28,720 --> 01:20:30,040 TO USE BUT PREDOMINANT FUNDS 2197 01:20:30,040 --> 01:20:32,120 WILL BE USED FOR THOSE FUNDS. 2198 01:20:32,120 --> 01:20:33,640 FOR THOSE PROGRAM MANAGERS. 2199 01:20:33,640 --> 01:20:35,640 SO AS WE HIRE THEM THAT'S HOW I 2200 01:20:35,640 --> 01:20:37,480 KNOW WHAT WE'LL SPEND THE MONEY 2201 01:20:37,480 --> 01:20:37,800 ON. 2202 01:20:37,800 --> 01:20:40,440 SO THAT'S -- BUT IT'S NOT BEEN 2203 01:20:40,440 --> 01:20:40,840 PRE-DETERMINED. 2204 01:20:40,840 --> 01:20:42,880 THAT IS ONE OF THE FREEDOMS 2205 01:20:42,880 --> 01:20:44,080 GIVEN TO THE ORGANIZATION THAT 2206 01:20:44,080 --> 01:20:45,840 WE SELECT ON A ROLLING BASIS 2207 01:20:45,840 --> 01:20:47,800 WHAT PROJECTS THAT WE'LL FUND. 2208 01:20:47,800 --> 01:20:50,880 >>THANK YOU. 2209 01:20:50,880 --> 01:20:51,000 2210 01:20:51,000 --> 01:21:01,240 >>ANY OTHER QUESTIONS FOR DR. 2211 01:21:01,240 --> 01:21:01,800 WEGRYZN? 2212 01:21:01,800 --> 01:21:02,800 SEEING NONE, THANK YOU, RENEE 2213 01:21:02,800 --> 01:21:03,280 FOR JOINING US. 2214 01:21:03,280 --> 01:21:05,080 >>WE'LL TAKE A FIVE-MINUTE 2215 01:21:05,080 --> 01:21:07,040 BREAK TO PREPARED FOR THE CLOSED 2216 01:21:07,040 --> 01:21:08,040 SESSION. 2217 01:21:08,040 --> 01:21:09,440 WE ASK ALL NON-GOVERNMENT 2218 01:21:09,440 --> 01:21:11,240 EMPLOYEES LEAVE THE ROOM. 2219 01:21:11,240 --> 01:21:12,680 COUNCIL MEMBERS SHOULD REMAIN SO 2220 01:21:12,680 --> 01:21:13,000 WE CAN GO TO THE CLOSED SESSION 2221 01:21:13,000 --> 00:00:00,000 TO REVIEW GRANT APPLICATIONS.