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OKAY, EVERYONE.

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GOOD MORNING.

3
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IT'S TIME TO CALL TO ORDER OUR 

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JOINT COLLABORATIVE RESEARCH ON 

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ADDICTIONS AT NIH COUNCIL 

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MEETING.

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I'M REALLY HAPPY NORAH VOLKOW 

8
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AND WILLIAM KLEIN ARE WITH US 

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TODAY.

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THIS IS THE 13th JOINT MEETING 

11
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OF NIAAA, NCI AND NIDA AND THE 

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12th MEETING ON COLLABORATIVE 

13
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RESEARCH ON ADDICTIONS AT NIH.

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SO I'M GOING TO ASK ALL THE 

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COUNCIL MEMBERS TO TELL US WHERE

16
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THEY ARE FROM AND MAYBE ONE 

17
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SENTENCE ABOUT THEIR DOMAIN OF 

18
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RESEARCH.

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I'M GOING TO JUST GO THROUGH THE

20
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LIST AND READ THEM.

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AND I APOLOGIZE IF I DON'T 

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COMPLETELY PRONOUNCE YOUR NAME 

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PROPERLY.

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ARPANA.

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>> HI, DR. KOOB.

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I'M AT WASHINGTON UNIVERSITY AND

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MY AREA OF RESEARCH IS 

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ENVIRONMENTAL ON SUBSTANCE USE 

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DISORDERS.

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>> KATE BEBE.

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>> I'M FROM MILL VALLEY, 

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CALIFORNIA, AND MY AREA IS 

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OPIOID USE DISORDER AND 

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LONG-TERM TREATMENT DEVELOPMENT 

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FOR DRUGS OF ADDICTION.

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>> DEBORAH CHASSLER.

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>> CHARLIE -- 

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>> GOOD MORNING, GEORGE
AND 

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TEAM.

40
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I'M A PROFESSOR AT THE 

41
00:02:04,712 --> 00:02:06,748
UNIVERSITY OF WASHINGTON AND I 

42
00:02:06,748 --> 00:02:08,216
STUDY STRESS MECHANISMS AND HOW 

43
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THAT LEADS TO INCREASE IN DRUG 

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ADDICTION RISK.

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>> THANKS, CHARLES.

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AND CHRISTIAN DUARTE.

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>> I STUDY DEVELOPMENTAL 

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PSYCHOPATHOLOGY AND SUBSTANCE 

49
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USE WITH A GREAT INTEREST IN 

50
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INTERGENERATIONAL PROCESSES.

51
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>> THANKS.

52
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IZE -- BUSINESS BELL DURAN.

53
00:02:44,285 --> 00:02:46,988
>> WE ARE IN LATINO CANCER

54
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INSTITUTE BASED IN CALIFORNIA.

55
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I AM WITH THE NCAB AND PATIENT 

56
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ADVOCATE.

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NICE TO BE HERE WITH YOU THIS 

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MORNING.

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SORRY I COULDN'T BE WITH YOU IN 

60
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PERSON.

61
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I'M NOT MONTREAL AT ANOTHER 

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CONVERSATION.

63
00:03:00,835 --> 00:03:02,570
TRYING TO DEAL WITH THE 

64
00:03:02,570 --> 00:03:03,304
TECHNOLOGY HERE.

65
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>> THANKS, ISABELLE.

66
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>> KAREN EM DMONDS.

67
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>> I'M AT HARVARD, CANCER
-- 

68
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>> THANKS, KAREN.

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AHMET EDKIN.

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>> HE'S NOT THERE.

71
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>> NO.

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OKAY.

73
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TAMICHA FELDER.

74
00:03:32,200 --> 00:03:34,469
>> HELLO, EVERYONE.

75
00:03:34,469 --> 00:03:38,206
TAMICHA FELDER, CERVICAL CANCER 

76
00:03:38,206 --> 00:03:39,374
SURVIVOR PATIENT ENGAGEMENT AND 

77
00:03:39,374 --> 00:03:41,442
SUPPORT WITH SURVIVOR, INC, 

78
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BASED IN MARYLAND BUT WE SERVE 

79
00:03:45,980 --> 00:03:46,281
NATIONALLY.

80
00:03:46,281 --> 00:03:51,452
>> NANCY GONZALEZ.

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I DON'T THINK SHE MADE IT.

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ELENA HANSON.

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>> GOOD MORNING.

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ELENA HANSON.

85
00:03:58,459 --> 00:04:04,165
I'M AT UCLA IN LOS ANGELES AND 

86
00:04:04,165 --> 00:04:11,539
IN THE PSYCHIATRY AND ARNT RO 

87
00:04:11,539 --> 00:04:14,075
APOLOGY STUDYING SUB STAUSS USE 

88
00:04:14,075 --> 00:04:18,546
DRIVERS AND OUTCOMES.

89
00:04:18,546 --> 00:04:21,482
>> AMY BETH HINBERGER.

90
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>> GOOD MORNING,
SCIENTIFIC 

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00:04:25,053 --> 00:04:27,455
DIRECTOR OF THE -- BRAIN 

92
00:04:27,455 --> 00:04:32,760
INSTITUTE IN CHICAGO AND I'M ON 

93
00:04:32,760 --> 00:04:35,196
THE NATIONAL CANCER ADVISORY 

94
00:04:35,196 --> 00:04:35,964
BOARD.

95
00:04:35,964 --> 00:04:37,532
>> HAYDEN HUSCAMP.

96
00:04:37,532 --> 00:04:39,968
>> I'M A HEALTH ECONOMIST
FROM 

97
00:04:39,968 --> 00:04:42,070
HARVARD AND I DO ADDICTION 

98
00:04:42,070 --> 00:04:45,106
POLICY AND SERVICES RESEARCH.

99
00:04:45,106 --> 00:04:49,911
>> THANKS, HAYDEN.

100
00:04:49,911 --> 00:04:51,379
DAVID KARIKEN.

101
00:04:51,379 --> 00:04:54,415
>> GOOD MORNING,
EVERYBODY.

102
00:04:54,415 --> 00:04:56,084
PROFESSOR AND VICE CHAIR FOR 

103
00:04:56,084 --> 00:04:58,686
RESEARCH IN NEUROLOGY AND AT THE

104
00:04:58,686 --> 00:04:59,921
YIND UNIVERSITY SCHOOL OF 

105
00:04:59,921 --> 00:05:02,090
MEDICINE AND DIRECTOR OF THE 

106
00:05:02,090 --> 00:05:03,157
ALCOHOL RESEARCH CENTER HERE.

107
00:05:03,157 --> 00:05:06,361
MY OWN RESEARCH IS IN THE AREA 

108
00:05:06,361 --> 00:05:09,998
OF NEUROIMAGING OF RISK FACTORS 

109
00:05:09,998 --> 00:05:13,334
OF -- DISORDER.

110
00:05:13,334 --> 00:05:15,937
>> REGINA LA BELL.

111
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THANKS, DAVID.

112
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REGINA LA BELL.

113
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>> GOOD MORNING.

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MY NAME IS REGINA LA BELL.

115
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I'M AT GEORGETOWN UNIVERSITY 

116
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WHERE I'M A PROFESSOR AND 

117
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DREBLGT THE MASTER OF SCIENCE 

118
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ADDICTION POLICY AND PRACTICE.

119
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I WORK ON ADDICTION POLICY 

120
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ISSUES.

121
00:05:31,019 --> 00:05:33,621
>> THANKS, REGINA.

122
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ANGELA LAIRD.

123
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>> GOOD MORNING, EVERYONE.

124
00:05:36,824 --> 00:05:38,860
ANGIE LAIRD, DEPARTMENT OF 

125
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PHYSICS AT FLORIDA INTERNATIONAL

126
00:05:39,994 --> 00:05:42,096
UNIVERSITY IN MIAMI.

127
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MY FIELD OF RESEARCH IS 

128
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NEUROINFOMTIC AND AN ABCD SITE 

129
00:05:52,040 --> 00:05:52,940
TI.

130
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>> AND FRANCES LEVEN.

131
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>> I DON'T THINK HE IS
THERE.

132
00:05:57,845 --> 00:06:01,549
>> MICHAEL LEWIS.

133
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>> I'M MICHAEL LEWIS.

134
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I'M GETTING AN ECHO HERE.

135
00:06:04,686 --> 00:06:06,754
I HOPE YOU ARE NOT HEARING THAT.

136
00:06:06,754 --> 00:06:07,655
>> NO.

137
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IT'S OKAY, MICHAEL.

138
00:06:09,857 --> 00:06:11,125
>> OKAY.

139
00:06:11,125 --> 00:06:14,095
I'M PROFESSOR AT HUNTER COLLEGE 

140
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AND AT THE GRADUATE CENTER CITY 

141
00:06:16,931 --> 00:06:18,132
UNIVERSITY OF NEW YORK.

142
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I'M INTERESTED IN MOTIVATION AND

143
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NUTRITIONAL ISSUES INVOLVED WITH

144
00:06:24,105 --> 00:06:27,075
ALCOHOL USE DISORDER.

145
00:06:27,075 --> 00:06:28,343
>> THANKS, MICHAEL.

146
00:06:28,343 --> 00:06:30,845
AND DANE MAYFIELD.

147
00:06:30,845 --> 00:06:32,313
>> GOOD MORNING,
EVERYBODY.

148
00:06:32,313 --> 00:06:33,414
I'M DANE MAYFIELD.

149
00:06:33,414 --> 00:06:36,084
I'M WITH THE WAGNER CENTER FOR 

150
00:06:36,084 --> 00:06:37,719
ALCOHOL AND ADDICTION RESEARCH 

151
00:06:37,719 --> 00:06:39,287
AT THE UNIVERSITY OF TEXAS AT 

152
00:06:39,287 --> 00:06:42,724
AUSTIN AND I STUDY MOLECULAR 

153
00:06:42,724 --> 00:06:45,360
MECHANISMS OF AUD.

154
00:06:45,360 --> 00:06:47,862
>> THANKS, DANE.

155
00:06:47,862 --> 00:06:58,139
ANNA NAVASASIAN.

156
00:07:03,578 --> 00:07:03,845
EDYANYGUYEN 

157
00:07:03,845 --> 00:07:07,448
>> NEUROSURGEON SCIENTIST.

158
00:07:07,448 --> 00:07:09,283
DIRECTOR OF THE WINSHIP TUMOR 

159
00:07:09,283 --> 00:07:10,151
CENTER.

160
00:07:10,151 --> 00:07:12,954
MY RESEARCH IS TUMOR IMMUNOLOGY 

161
00:07:12,954 --> 00:07:20,895
AND IMMUNE THERAPY FOR TUMORS.

162
00:07:20,895 --> 00:07:26,768
>> MELANIE OTT.

163
00:07:26,768 --> 00:07:30,037
OKAY.

164
00:07:30,037 --> 00:07:34,976
AND FRED -- 

165
00:07:34,976 --> 00:07:39,781
YOU ARE MUTED, FRED.

166
00:07:39,781 --> 00:07:41,082
TRY AGAIN.

167
00:07:41,082 --> 00:07:43,918
>> SORRY ABOUT THAT.

168
00:07:43,918 --> 00:07:46,587
>> GOOD NOW.

169
00:07:46,587 --> 00:07:50,158
MY NAME IS FRED -- AND I AM AN 

170
00:07:50,158 --> 00:07:51,592
ASSISTANT PROFESSOR AT THE OHIO 

171
00:07:51,592 --> 00:07:53,861
STATE UNIVERSITY COLLEGE OF 

172
00:07:53,861 --> 00:07:56,497
MEDICINE AND COMPREHENSIVE 

173
00:07:56,497 --> 00:07:57,064
CANCER CENTER.

174
00:07:57,064 --> 00:08:00,301
MY LAB STUDIES THE ROLE OF DIET 

175
00:08:00,301 --> 00:08:01,836
AND LIFESTYLE IN CANCER 

176
00:08:01,836 --> 00:08:02,870
PREVENTION AND TREATMENT 

177
00:08:02,870 --> 00:08:03,671
RESPONSE.

178
00:08:03,671 --> 00:08:05,473
I'M WITH THE NATIONAL CANCER 

179
00:08:05,473 --> 00:08:05,840
ADVISORY BOARD.

180
00:08:05,840 --> 00:08:08,476
THANK YOU.

181
00:08:08,476 --> 00:08:11,479
>> THANKS, FRED.

182
00:08:11,479 --> 00:08:16,651
MARK VONN ZASTER.

183
00:08:16,651 --> 00:08:19,454
I DON'T THINK MARK IS WITH US.

184
00:08:19,454 --> 00:08:19,654
OKAY.

185
00:08:19,654 --> 00:08:23,424
SO I WOULD LIKE TO NOW GO AROUND

186
00:08:23,424 --> 00:08:26,294
THE ROOM AT THE TABLE HERE AND 

187
00:08:26,294 --> 00:08:27,962
HAVE EVERYONE INTRODUCE 

188
00:08:27,962 --> 00:08:28,262
THEMSELVES.

189
00:08:28,262 --> 00:08:30,932
SO WE'LL START WITH YOU, 

190
00:08:30,932 --> 00:08:31,199
ELIZABETH.

191
00:08:31,199 --> 00:08:37,738
IF THAT'S OKAY.

192
00:08:37,738 --> 00:08:39,173
>> GOOD MORNING.

193
00:08:39,173 --> 00:08:41,242
I'M ELIZABETH HOFFMANN, 

194
00:08:41,242 --> 00:08:43,277
ASSOCIATE DIRECTOR FOR THE ABCD 

195
00:08:43,277 --> 00:08:44,045
STUDIED A NIDA.

196
00:08:44,045 --> 00:08:48,349
>> CHRIS 

197
00:08:48,349 --> 00:08:50,818
>> I'M CHRISTOPHER
SARAMPOTE AND

198
00:08:50,818 --> 00:08:54,222
PROJECT DIRECTOR FOR THE ABCD 

199
00:08:54,222 --> 00:08:57,492
STUDY AND X RESEARCH AT NIDA.

200
00:08:57,492 --> 00:08:59,927
>> I'M PHILLIP, I'M THE
DIRECTOR

201
00:08:59,927 --> 00:09:03,464
OF EXTERNAL ACTIVITIES AT NIAAA.

202
00:09:03,464 --> 00:09:06,934
>> I'M TRISH -- I'M THE
DEPUTY 

203
00:09:06,934 --> 00:09:08,035
DIRECTOR AT THE NATIONAL 

204
00:09:08,035 --> 00:09:09,537
INSTITUTE ON ALCOHOL ABUSE AND 

205
00:09:09,537 --> 00:09:10,171
ALCOHOLISM.

206
00:09:10,171 --> 00:09:10,505
>> BILL.

207
00:09:10,505 --> 00:09:15,042
>> GOOD MORNING, BIM
KLEIN, 

208
00:09:15,042 --> 00:09:17,578
ASSOCIATE DIRECTOR OF BAIFRLT 

209
00:09:17,578 --> 00:09:19,447
RESEARCH AT THE NARNS CANCER 

210
00:09:19,447 --> 00:09:20,214
INSTITUTE.

211
00:09:20,214 --> 00:09:22,083
>> WILSON COMPTON,
NATIONAL 

212
00:09:22,083 --> 00:09:23,551
INSTITUTE ON DRUG ABUSE.

213
00:09:23,551 --> 00:09:25,987
>> SUSAN WEISS, DIRECTOR
OF THE 

214
00:09:25,987 --> 00:09:28,222
DIVISION OF EXTRA MURAL RESEARCH

215
00:09:28,222 --> 00:09:29,457
AT NIDA.

216
00:09:29,457 --> 00:09:30,691
>> AND GAYA.

217
00:09:30,691 --> 00:09:34,529
>> GAYA DOWLING, DIRECTOR
OF 

218
00:09:34,529 --> 00:09:36,430
ABCD PROJECT AND I'M AT NIDA.

219
00:09:36,430 --> 00:09:39,967
>> NORAH, MAKE SURE WE GET
YOU.

220
00:09:39,967 --> 00:09:41,369
>> OKAY.

221
00:09:41,369 --> 00:09:45,940
THANKS FOR NOT FORGETTING ME 

222
00:09:45,940 --> 00:09:46,173
GEORGE.

223
00:09:46,173 --> 00:09:49,877
I'M NORAH VOLKO KS W, DIRECTOR 

224
00:09:49,877 --> 00:09:51,779
OOF THE NATIONAL INSTITUTE ON 

225
00:09:51,779 --> 00:09:52,713
DRUG ABUSE.

226
00:09:52,713 --> 00:09:55,616
I WAS HOPING ALL OF THESE WOULD 

227
00:09:55,616 --> 00:09:56,684
BE DONE IN PLACE.

228
00:09:56,684 --> 00:09:58,653
I OPTED FOR TECHNOLOGY.

229
00:09:58,653 --> 00:10:01,322
SO I LOOK A FORWARD FOR HEARING 

230
00:10:01,322 --> 00:10:01,822
YOUR RECOMMENDATIONS.

231
00:10:01,822 --> 00:10:05,026
SO I PASS IT BACK TO YOU, 

232
00:10:05,026 --> 00:10:05,293
GEORGE.

233
00:10:05,293 --> 00:10:08,162
>> AND I'M GEORGE KOOB,
THE 

234
00:10:08,162 --> 00:10:09,897
DIRECTOR OF THE NATIONAL 

235
00:10:09,897 --> 00:10:11,532
INSTITUTE ON ALCOHOL ABUSE AND 

236
00:10:11,532 --> 00:10:11,832
ALCOHOLISM.

237
00:10:11,832 --> 00:10:22,310
SO I GUESS I'M SUPPOSED TO -- 

238
00:10:22,310 --> 00:10:22,510
SORRY.

239
00:10:22,510 --> 00:10:25,479
I WOULD LIKE TO INTRODUCE -- ASK

240
00:10:25,479 --> 00:10:28,082
PAUL LET GRAY TO INTRODUCE 

241
00:10:28,082 --> 00:10:28,316
HERSELF.

242
00:10:28,316 --> 00:10:31,352
>> I'M PAULLETTE GRAY,
DIRECTOR 

243
00:10:31,352 --> 00:10:35,590
OF THE DIVISION OF E TRA MURAL 

244
00:10:35,590 --> 00:10:39,460
ACTIVITIES AT THE NATIONAL 

245
00:10:39,460 --> 00:10:40,361
CANCER INSTITUTE.

246
00:10:40,361 --> 00:10:50,705
>> THANK YOU, PAULA.

247
00:11:14,528 --> 00:11:15,529
>> OKAY.

248
00:11:15,529 --> 00:11:17,365
GOOD MORNING, EVERYONE.

249
00:11:17,365 --> 00:11:19,667
I'M GOING TO GIVE A BRIEF 

250
00:11:19,667 --> 00:11:22,069
INTRODUCTION TO CRAN AND TALK A 

251
00:11:22,069 --> 00:11:25,272
LITTLE BIT ABOUT NIAAA UPDATE.

252
00:11:25,272 --> 00:11:27,174
IT SHOULD BE RELATIVELY SHORT.

253
00:11:27,174 --> 00:11:28,643
MAYBE A REVIEW FOR MANY OF YOU, 

254
00:11:28,643 --> 00:11:30,378
BUT A COUPLE OF THINGS WE WOULD 

255
00:11:30,378 --> 00:11:34,148
LIKE TO HIGHLIGHT FROM NIAAA.

256
00:11:34,148 --> 00:11:36,183
THE COLLABORATIVE RESEARCH ON 

257
00:11:36,183 --> 00:11:37,852
ADDICTION AT NIH ENHANCES 

258
00:11:37,852 --> 00:11:39,120
COLLABORATION AT NIH.

259
00:11:39,120 --> 00:11:43,090
OUR PURPOSE IS TO DO THIS WITH 

260
00:11:43,090 --> 00:11:49,230
BOTH NIAAA, NIDA, NCI AND 

261
00:11:49,230 --> 00:11:50,698
SUBSTANCE USE MISUSE AND PUBLIC 

262
00:11:50,698 --> 00:11:51,899
HEALTH OUTCOMES.

263
00:11:51,899 --> 00:11:53,901
THERE IS A STEERING COMMITTEE 

264
00:11:53,901 --> 00:11:55,002
COMPRISING THE DIRECTORS OF 

265
00:11:55,002 --> 00:11:57,138
NIAAA, NIDA AND THE DIVISION OF 

266
00:11:57,138 --> 00:11:58,773
CANCER CONTROL AND POPULATION 

267
00:11:58,773 --> 00:12:01,242
SCIENCES AT NCI, WHICH IS BILL 

268
00:12:01,242 --> 00:12:03,411
KLEIN.

269
00:12:03,411 --> 00:12:04,545
COORDINATING COMMITTEE STAFF BY 

270
00:12:04,545 --> 00:12:07,314
REPRESENTATIVES FROM EACH OF THE

271
00:12:07,314 --> 00:12:09,917
THREE ICs IS PART OF THE GONS.

272
00:12:09,917 --> 00:12:11,819
WHAT DO WE DO?

273
00:12:11,819 --> 00:12:14,955
WELL, WE HAVE ONGOING PROGRAMS 

274
00:12:14,955 --> 00:12:17,558
THAT WE FUND AND COOPERATE AND 

275
00:12:17,558 --> 00:12:18,426
COLLABORATE ON.

276
00:12:18,426 --> 00:12:20,528
THE ADOLESCENT BRAIN COGNITIVE 

277
00:12:20,528 --> 00:12:23,097
DEVELOPMENT STUDY, THE LARGEST 

278
00:12:23,097 --> 00:12:24,732
LONG-TERM STUDY ON BRAIN 

279
00:12:24,732 --> 00:12:26,000
DEVELOPMENT AND CHILD HEALTH IN 

280
00:12:26,000 --> 00:12:27,735
THE UNITED STATES THIS YOU WILL 

281
00:12:27,735 --> 00:12:29,503
HEAR ABOUT LATER TODAY.

282
00:12:29,503 --> 00:12:30,204
HEALTHY BRAIN AND CHILD 

283
00:12:30,204 --> 00:12:34,709
DEVELOPMENT STUDY, HBCD, FOLLOWS

284
00:12:34,709 --> 00:12:36,043
CHILDREN FROM BIRTH TO LONG-TERM

285
00:12:36,043 --> 00:12:40,214
EFFECTS OF PERI NATAL DRUG 

286
00:12:40,214 --> 00:12:41,482
EXPOSURE ON DEVELOPMENT.

287
00:12:41,482 --> 00:12:43,184
WE HAVE HIGHLIGHTED 

288
00:12:43,184 --> 00:12:46,921
COLLABORATIONS.

289
00:12:46,921 --> 00:12:48,189
SCREENING, BRIEF INTERVENTION 

290
00:12:48,189 --> 00:12:49,957
AND REFERRAL TO TREATMENT FOR 

291
00:12:49,957 --> 00:12:52,226
PREVENTION FOR ALCOHOL, TOBACCO 

292
00:12:52,226 --> 00:12:54,762
AND OTHER DRUGS USE AND MISUSE 

293
00:12:54,762 --> 00:12:56,797
IN ADULT POPULATIONS THAT 

294
00:12:56,797 --> 00:13:03,704
EXPERIENCE HEALTH DISPARITIES.

295
00:13:03,704 --> 00:13:11,645
AN POPULATION APPROACHES TO -- 

296
00:13:11,645 --> 00:13:17,585
>> WE HOLD ANNUAL JOINT
EVENTS.

297
00:13:17,585 --> 00:13:19,220
JOINT CRAN FACILITATES, RESEARCH

298
00:13:19,220 --> 00:13:20,488
PRIORITIES, ACCOMPLISHMENTS AND 

299
00:13:20,488 --> 00:13:21,455
OPPORTUNITIES FOR COLLABORATION.

300
00:13:21,455 --> 00:13:24,525
WE DO THE NIDA, NIAAA 

301
00:13:24,525 --> 00:13:25,659
MINICONVENTION FRONTIERS IN 

302
00:13:25,659 --> 00:13:26,227
ADDICTION RESEARCH.

303
00:13:26,227 --> 00:13:28,162
THIS PROVIDES A FORUM FOR 

304
00:13:28,162 --> 00:13:34,835
PRESENTATIONS AND DISCUSSIONS OF

305
00:13:34,835 --> 00:13:38,072
CURRENT NEUROSCIENCE AND 

306
00:13:38,072 --> 00:13:40,007
RESEARCH TOPICS.

307
00:13:40,007 --> 00:13:44,011
THIS HAS REALLY BEEN AN EXCITING

308
00:13:44,011 --> 00:13:45,946
MINICONVENTION THAT WE HAVE BEEN

309
00:13:45,946 --> 00:13:47,081
DOING NOW FOR QUITE SOME TIME.

310
00:13:47,081 --> 00:13:50,885
AND SOME OF THE BEST YOUNG 

311
00:13:50,885 --> 00:13:52,887
PEOPLE PRESENT IN THIS VENUE.

312
00:13:52,887 --> 00:13:56,056
MEDIA EVENTS AT THE SOCIETY FOR 

313
00:13:56,056 --> 00:13:57,424
NEUROSCIENCE AND COLLEGE ON 

314
00:13:57,424 --> 00:13:58,959
PROBLEMS OF DRUG DEPENDENCE.

315
00:13:58,959 --> 00:14:01,428
WE USED TO UPDATE THE PRESS 

316
00:14:01,428 --> 00:14:02,296
ABOUT NEW SCIENCE AND CHALLENGES

317
00:14:02,296 --> 00:14:04,198
AND OPPORTUNITIES IN THE 

318
00:14:04,198 --> 00:14:09,303
ADDICTION RESEARCH FIELD.

319
00:14:09,303 --> 00:14:12,006
SO HERE'S OUR UPDATE FROM NIAAA.

320
00:14:12,006 --> 00:14:16,977
I'M GOING TO BRIEFLY TALK ABOUT 

321
00:14:16,977 --> 00:14:19,880
ALCOHOL MISUSE AS A CHRONIC 

322
00:14:19,880 --> 00:14:20,581
DISORDER.

323
00:14:20,581 --> 00:14:24,185
CHRONIC DISEASE IS A MAJOR 

324
00:14:24,185 --> 00:14:32,193
COMPONENT OF DR. BHATTACHARYA'S 

325
00:14:32,193 --> 00:14:32,359
AIM.

326
00:14:32,359 --> 00:14:36,197
IF I MAY SAY SO, ALCOHOL USE 

327
00:14:36,197 --> 00:14:37,698
DISORDER AND SUBSTANCE USE 

328
00:14:37,698 --> 00:14:39,200
DISORDER ARE POSTER CHILDREN FOR

329
00:14:39,200 --> 00:14:49,510
CHRONIC DISEASES.

330
00:15:05,292 --> 00:15:08,095
THE CHRONIC HEALTH USE DISORDER.

331
00:15:08,095 --> 00:15:10,531
WE HAVE A PREDIJ NOUS NUMBER OF 

332
00:15:10,531 --> 00:15:11,899
EMERGENCY ROOM VISITS.

333
00:15:11,899 --> 00:15:14,268
I HAVE SAID THIS IF YOU GO INTO 

334
00:15:14,268 --> 00:15:15,970
ANY MAJOR MEDICAL CENTER ON A 

335
00:15:15,970 --> 00:15:17,504
FRIDAY OR SATURDAY NIGHT, THE 

336
00:15:17,504 --> 00:15:19,340
EMERGENCY ROOM, HALF OF THE 

337
00:15:19,340 --> 00:15:20,774
PEOPLE ARE THERE BECAUSE OF 

338
00:15:20,774 --> 00:15:21,575
ALCOHOL.

339
00:15:21,575 --> 00:15:22,610
WE LOSE 180,000 PEOPLE A YEAR TO

340
00:15:22,610 --> 00:15:28,082
ALCOHOL.

341
00:15:28,082 --> 00:15:29,917
 THERE HAS BEEN INTERESTINGLY 

342
00:15:29,917 --> 00:15:32,620
ENOUGH, A DRAMATIC INCREASE IN 

343
00:15:32,620 --> 00:15:34,355
ALCOHOL RELATED DEATHS IN THE 

344
00:15:34,355 --> 00:15:36,824
LAST 20 YEARS, SINCE 2001.

345
00:15:36,824 --> 00:15:41,896
AND THEY HAVEN'T STOPPED GOING 

346
00:15:41,896 --> 00:15:42,096
UP.

347
00:15:42,096 --> 00:15:45,266
SOME OF THIS WAS OBVIOUSLY 

348
00:15:45,266 --> 00:15:47,801
EXACERBATED BY THE PANDEMIC, AS 

349
00:15:47,801 --> 00:15:49,603
I WILL TOUCH ON BRIEFLY, BUT IT 

350
00:15:49,603 --> 00:15:52,573
IS A STEADY INCREASE AND THE 

351
00:15:52,573 --> 00:15:54,108
PATHOLOGY ASSOCIATED WITH 

352
00:15:54,108 --> 00:15:56,944
ALCOHOL, WHICH IS MANIFEST HAS 

353
00:15:56,944 --> 00:15:59,813
BEEN INCREASING IN PARALLEL.

354
00:15:59,813 --> 00:16:04,418
MORE THAN 200 DISEASES AND 

355
00:16:04,418 --> 00:16:05,252
INJURY-RELATED CONDITIONS 

356
00:16:05,252 --> 00:16:06,320
ASSOCIATED WITH ALCOHOL.

357
00:16:06,320 --> 00:16:07,655
YOU ARE PROBABLY MOST FAMILIAR 

358
00:16:07,655 --> 00:16:09,757
WITH THE LIVER, WE HAD A TALK 

359
00:16:09,757 --> 00:16:12,259
YESTERDAY ON LUNG, WHICH WAS 

360
00:16:12,259 --> 00:16:17,798
REALLY EXCITING FROM DR. SINAR 

361
00:16:17,798 --> 00:16:20,701
IN OUR INTRAMURAL PROGRAM.

362
00:16:20,701 --> 00:16:24,371
IT RANGES FROM MENTAL HEALTH 

363
00:16:24,371 --> 00:16:26,674
PROBLEMS TO CANCER AND I WILL 

364
00:16:26,674 --> 00:16:27,641
TOUCH ON THEM.

365
00:16:27,641 --> 00:16:29,310
ALCOHOL ASSOCIATED LIVER DISEASE

366
00:16:29,310 --> 00:16:30,978
IS THE MOST COMMON 

367
00:16:30,978 --> 00:16:32,379
ALCOHOL-RELATED CAUSE OF DEATH.

368
00:16:32,379 --> 00:16:38,285
AND ACCOUNTS FOR ABOUT 50% OF 

369
00:16:38,285 --> 00:16:39,320
LIVER ASSOCIATED DEATHS.

370
00:16:39,320 --> 00:16:42,423
THE DEATH RATES ARE INCREASING 

371
00:16:42,423 --> 00:16:43,991
FASTER FOR WOMEN AND AMONG YOUNG

372
00:16:43,991 --> 00:16:44,224
ADULTS.

373
00:16:44,224 --> 00:16:45,626
THERE ARE INDIVIDUALS WHO ARE 

374
00:16:45,626 --> 00:16:48,062
YOUNGER THAN 30 YEARS OLD 

375
00:16:48,062 --> 00:16:49,596
GETTING LIVER TRANSPLANTS 

376
00:16:49,596 --> 00:16:51,765
BECAUSE OF ALCOHOL ASSOCIATED 

377
00:16:51,765 --> 00:16:54,234
LIVER DISEASE.

378
00:16:54,234 --> 00:16:55,069
SERIOUS ALCOHOL ASSOCIATED LIVER

379
00:16:55,069 --> 00:16:55,302
DISEASE.

380
00:16:55,302 --> 00:16:58,872
YOU KNOW IT IS A SPECTRUM 

381
00:16:58,872 --> 00:17:00,007
DISORDER ITSELF.

382
00:17:00,007 --> 00:17:05,846
RANGING FROM FIBROSIS TO 

383
00:17:05,846 --> 00:17:07,514
CIRRHOSIS AND EVEN LIVER CANCER 

384
00:17:07,514 --> 00:17:12,386
WHICH IS  CARCINOMA.

385
00:17:12,386 --> 00:17:15,289
IT PEAKED IN THE PANDEMIC AND 

386
00:17:15,289 --> 00:17:17,891
HAS GONE DOWN SLIGHTLY, BUT WE 

387
00:17:17,891 --> 00:17:19,793
ARE WAY ABOVE LEVELS FROM 20 

388
00:17:19,793 --> 00:17:21,328
YEARS AGO.

389
00:17:21,328 --> 00:17:22,997
THERE IS A SHIFT FOR MORE 

390
00:17:22,997 --> 00:17:24,331
PROBLEMS WITH WOMEN AND YOUNGER 

391
00:17:24,331 --> 00:17:25,632
PEOPLE WITH LIVER DISEASE WHICH 

392
00:17:25,632 --> 00:17:27,468
I SUSPECT IS A REFLECTION OF 

393
00:17:27,468 --> 00:17:30,371
THOSE WHO DRINK, DRINKING MUCH 

394
00:17:30,371 --> 00:17:31,105
MORE HEAVILY.

395
00:17:31,105 --> 00:17:33,507
ALCOHOL INCREASING THE RISK OF 

396
00:17:33,507 --> 00:17:35,309
AT LEAST SEVEN TYPES OF CANCER.

397
00:17:35,309 --> 00:17:38,278
ALCOHOL CONSUMPTION IS THE THIRD

398
00:17:38,278 --> 00:17:39,613
LEADING PREVENTABLE CAUSE OF 

399
00:17:39,613 --> 00:17:41,015
CANCER IN UNITED STATES AFTER 

400
00:17:41,015 --> 00:17:44,551
TOBACCO AND OBESITY.

401
00:17:44,551 --> 00:17:47,187
INCREASING CANCERS OF THE HEAD, 

402
00:17:47,187 --> 00:17:49,356
NECK, LIVER, COLON, LIVER AND 

403
00:17:49,356 --> 00:17:50,257
BREAST.

404
00:17:50,257 --> 00:17:52,793
WE HAVE TO THANK THE NATIONAL 

405
00:17:52,793 --> 00:17:54,528
CANCER INSTITUTE, BILL KLEIN'S 

406
00:17:54,528 --> 00:17:56,196
DIVISION AMONG OTHERS FOR A LOT 

407
00:17:56,196 --> 00:17:57,898
OF THE WORK THAT FOCUSED ON 

408
00:17:57,898 --> 00:18:00,768
ALCOHOL AND CANCER AND WE HAVE 

409
00:18:00,768 --> 00:18:01,435
ALWAYS BEEN HAPPY TO COLLABORATE

410
00:18:01,435 --> 00:18:03,103
WITH THEM.

411
00:18:03,103 --> 00:18:05,606
IN THE U.S. ALCOHOL CONSUMPTION 

412
00:18:05,606 --> 00:18:06,907
CONTRIBUTES TO 6% OF CANCER 

413
00:18:06,907 --> 00:18:09,643
CASES AND 4% OF DEATHS.

414
00:18:09,643 --> 00:18:11,145
BREAST, MOUTH AND THROAT CANCERS

415
00:18:11,145 --> 00:18:13,080
EVIDENCE SHOWS THIS RISK IS DOSE

416
00:18:13,080 --> 00:18:13,380
DEPENDENT.

417
00:18:13,380 --> 00:18:15,749
THE MORE YOU DRINK THE HIGHER 

418
00:18:15,749 --> 00:18:16,517
THE RISK.

419
00:18:16,517 --> 00:18:18,752
YET THERE IS A LARGE GAP IN THE 

420
00:18:18,752 --> 00:18:20,721
PUBLIC'S UNDERSTANDING OF 2019 

421
00:18:20,721 --> 00:18:24,191
SURVEY SHOWED THAT ONLY 45% OF 

422
00:18:24,191 --> 00:18:25,793
AMERICANS RECOGNIZE ALCOHOL USE 

423
00:18:25,793 --> 00:18:28,429
AS A RISK FOR CANCER COMPARED TO

424
00:18:28,429 --> 00:18:31,865
89% FOR TOBACCO USE.

425
00:18:31,865 --> 00:18:33,133
SO YOU HAVE BEEN VERY 

426
00:18:33,133 --> 00:18:35,035
SUCCESSFUL, BILL, WITH TOBACCO, 

427
00:18:35,035 --> 00:18:37,237
BUT WE NEED TO MOVE THE NEEDLE A

428
00:18:37,237 --> 00:18:38,806
LITTLE BIT WITH ALCOHOL.

429
00:18:38,806 --> 00:18:42,776
ALCOHOL MISUSE INCREASES THE 

430
00:18:42,776 --> 00:18:45,446
RISK FOR CARDIOVASCULAR DISEASE,

431
00:18:45,446 --> 00:18:50,184
IT CAN CONTRIBUTE TO HEART 

432
00:18:50,184 --> 00:18:52,386
ARRHYTHMIAS, HIGH BLOOD 

433
00:18:52,386 --> 00:18:58,025
PRESSURE, APEOPLE INA  -- 

434
00:18:58,025 --> 00:18:59,760
APEOPLE INA.

435
00:18:59,760 --> 00:19:02,062
CHRONIC ALCOHOL USE IS 

436
00:19:02,062 --> 00:19:04,198
EXACERBATED CARDIAC AND RESERVE 

437
00:19:04,198 --> 00:19:05,732
CAPACITY ASSOCIATED WITH AGING.

438
00:19:05,732 --> 00:19:08,068
MY COUNCIL HAS HEARD THIS, MY 

439
00:19:08,068 --> 00:19:09,703
STAFF HAVE HEARD THIS STORY 

440
00:19:09,703 --> 00:19:11,505
MULTIPLE TIMES, BUT LAST YEAR I 

441
00:19:11,505 --> 00:19:13,740
WENT TO THE MAYO CLINIC AND GAVE

442
00:19:13,740 --> 00:19:16,844
A TALK AND A CARDIOLOGIST TOLD 

443
00:19:16,844 --> 00:19:18,679
ME THE FIRST TREATMENT HE NOW 

444
00:19:18,679 --> 00:19:21,215
USES IN HIS PATIENTS FOR 

445
00:19:21,215 --> 00:19:23,383
HYPERTENSION IS TO ASK THEM HOW 

446
00:19:23,383 --> 00:19:24,151
MUCH THEY DRINK.

447
00:19:24,151 --> 00:19:26,787
AND APPARENTLY HYPERTENSION IS 

448
00:19:26,787 --> 00:19:27,788
DRIVING, I MEAN ALCOHOL IS 

449
00:19:27,788 --> 00:19:29,756
DRIVING QUITE A BIT OF 

450
00:19:29,756 --> 00:19:30,090
HYPERTENSION.

451
00:19:30,090 --> 00:19:32,993
SO TO SUMMARIZE THIS WHOLE 

452
00:19:32,993 --> 00:19:34,661
SECTION, WELL, WE ARE GOING TO 

453
00:19:34,661 --> 00:19:36,897
TALK ABOUT MENTAL HEALTH IN A 

454
00:19:36,897 --> 00:19:37,531
SECOND.

455
00:19:37,531 --> 00:19:39,133
BUT, YOU KNOW, ALCOHOL MISUSE IS

456
00:19:39,133 --> 00:19:40,834
A WINDOW ON SO MANY OTHER 

457
00:19:40,834 --> 00:19:42,169
PHYSICAL CONDITIONS AND MEDICAL 

458
00:19:42,169 --> 00:19:43,837
CONDITIONS AND WE'LL TALK ABOUT 

459
00:19:43,837 --> 00:19:48,509
WHY WE BELIEVE THAT IS IMPORTANT

460
00:19:48,509 --> 00:19:49,977
FOR ONE OF OUR PROGRAMS THAT WE 

461
00:19:49,977 --> 00:19:52,679
ARE ENGAGED IN.

462
00:19:52,679 --> 00:19:54,915
MENTAL HEALTH AND ALCOHOL USE 

463
00:19:54,915 --> 00:19:59,052
DISORDERS OFTEN CO-OCCUR 

464
00:19:59,052 --> 00:20:00,254
COMPLICATED DIAGNOSES AND 

465
00:20:00,254 --> 00:20:00,521
TREATMENT.

466
00:20:00,521 --> 00:20:04,191
THEY INCLUDE DEPRESSION AND PG 

467
00:20:04,191 --> 00:20:06,527
ANXIETY DISORDERS, ATTENTION 

468
00:20:06,527 --> 00:20:07,661
DEFICIT HYPERER ACTIVITY 

469
00:20:07,661 --> 00:20:07,928
DISORDER.

470
00:20:07,928 --> 00:20:10,063
ALCOHOL IS USED TO COPE WITH 

471
00:20:10,063 --> 00:20:10,330
STRESS.

472
00:20:10,330 --> 00:20:12,199
IF AN INDIVIDUAL EXPERIENCES 

473
00:20:12,199 --> 00:20:13,901
ANXIETY AND DEPRESSION THEY 

474
00:20:13,901 --> 00:20:17,704
COULD BE SENSITIVE TO WORSENING 

475
00:20:17,704 --> 00:20:19,106
ANXIETY OVER TIME DRIVEN IN PART

476
00:20:19,106 --> 00:20:21,408
BY ALCOHOL WHICH THEY ARE USING 

477
00:20:21,408 --> 00:20:23,010
TO TREAT THE ANXIETY.

478
00:20:23,010 --> 00:20:27,848
SO YOU GET INTO THIS KIND OF 

479
00:20:27,848 --> 00:20:28,849
SPIRITUALING LOOP.

480
00:20:28,849 --> 00:20:30,417
OTHER SUBSTANCE USE DISORDERS, 

481
00:20:30,417 --> 00:20:32,853
SLEEP DISORDERS AND CHRONIC PAIN

482
00:20:32,853 --> 00:20:35,589
ALSO COMMONLY OCCUR WITH ALCOHOL

483
00:20:35,589 --> 00:20:38,392
USE DISORDER AND CAN IMPACT 

484
00:20:38,392 --> 00:20:39,126
ALCOHOL USE DISORDER AND OTHER 

485
00:20:39,126 --> 00:20:41,595
MENTAL HEALTH CONDITIONS.

486
00:20:41,595 --> 00:20:44,398
SO MOST SUBSTANCE USE DISORDERS 

487
00:20:44,398 --> 00:20:45,265
GET INTO THAT SAME SPIRALLING 

488
00:20:45,265 --> 00:20:48,001
LOOP.

489
00:20:48,001 --> 00:20:49,503
OF SELF-MEDICATION.

490
00:20:49,503 --> 00:20:51,438
LEFT UNTREATED ALCOHOL AND 

491
00:20:51,438 --> 00:20:52,806
MENTAL HEALTH CONDITIONS MAY 

492
00:20:52,806 --> 00:20:55,876
INCREASE THE RISK FOR SUICIDE.

493
00:20:55,876 --> 00:20:58,712
AND THEN PRENATAL ALCOHOL 

494
00:20:58,712 --> 00:21:03,150
EXPOSURE CAN CAUSE LIFE-LONG 

495
00:21:03,150 --> 00:21:04,818
NEURODEVELOPMENTAL DEFICITS.

496
00:21:04,818 --> 00:21:06,520
THIS HAS ALWAYS BEEN A STRIKING 

497
00:21:06,520 --> 00:21:09,690
FACT.

498
00:21:09,690 --> 00:21:11,725
11% OF PREGNANT WOMEN REPORT 

499
00:21:11,725 --> 00:21:13,627
CURRENT ALCOHOL USE AND 5% 

500
00:21:13,627 --> 00:21:15,028
REPORT BING DRINKING.

501
00:21:15,028 --> 00:21:17,998
THERE IS NO KNOWN SAFE AMOUNT OF

502
00:21:17,998 --> 00:21:21,201
ALCOHOL CONSUMPTION DURING 

503
00:21:21,201 --> 00:21:21,468
PREGNANCY.

504
00:21:21,468 --> 00:21:23,070
IT CAN CAUSE BIRTH 

505
00:21:23,070 --> 00:21:24,905
COMPLICATIONS, BIRTH DEFECTS AND

506
00:21:24,905 --> 00:21:27,074
INCREASE THE RISK OF FETAL 

507
00:21:27,074 --> 00:21:33,480
ALCOHOL SPECTRUM DISORDERS, 

508
00:21:33,480 --> 00:21:36,450
WHICH IS A BROAD WIDE RANGE OF 

509
00:21:36,450 --> 00:21:39,386
IMPAIRMENTS THAT OCCUR DUE TO 

510
00:21:39,386 --> 00:21:42,322
ALCOHOL EXPOSURE BEFORE BIRTH.

511
00:21:42,322 --> 00:21:44,191
FETAL ALCOHOL SYNDROME ALL THE 

512
00:21:44,191 --> 00:21:46,126
WAY TO DEVELOPMENT DISORDERS 

513
00:21:46,126 --> 00:21:48,362
ASSOCIATED WITH ALCOHOL 

514
00:21:48,362 --> 00:21:49,263
EXPOSURE.

515
00:21:49,263 --> 00:21:51,965
INDIVIDUALS WITH FETAL ALCOHOL 

516
00:21:51,965 --> 00:21:52,899
SPECTRUM DISORDER MAY HAVE 

517
00:21:52,899 --> 00:21:54,001
PROBLEMS WITH ATTENTION, 

518
00:21:54,001 --> 00:21:56,937
LEARNING AND MEMORY.

519
00:21:56,937 --> 00:21:57,871
BEHAVIORAL REGULATION AND SOCIAL

520
00:21:57,871 --> 00:21:59,473
AND DAILY LIFE SKILLS.

521
00:21:59,473 --> 00:22:01,708
THEY ARE MORE LIKELY TO 

522
00:22:01,708 --> 00:22:02,843
EXPERIENCE MEDICAL ISSUES, 

523
00:22:02,843 --> 00:22:05,879
ALCOHOL AND OTHER SUBSTANCE USE 

524
00:22:05,879 --> 00:22:07,681
DISORDERS AND MENTAL HEALTH 

525
00:22:07,681 --> 00:22:08,181
DISORDERS.

526
00:22:08,181 --> 00:22:09,016
THEY OFTEN NEED SUPPORT 

527
00:22:09,016 --> 00:22:10,584
THROUGHOUT LIFE TO MITIGATE 

528
00:22:10,584 --> 00:22:11,451
THESE ISSUES.

529
00:22:11,451 --> 00:22:16,957
SO THIS IS REALLY, YOU KNOW, A 

530
00:22:16,957 --> 00:22:20,060
BIG PART OF OUR PORTFOLIO.

531
00:22:20,060 --> 00:22:22,596
IT IS AN IMPORTANT PART OF THE 

532
00:22:22,596 --> 00:22:23,263
PATHOLOGY ASSOCIATED WITH 

533
00:22:23,263 --> 00:22:25,399
ALCOHOL AND IT IS ESTIMATED 1% 

534
00:22:25,399 --> 00:22:27,634
TO 5% OF U.S. CHILDREN IN THE 

535
00:22:27,634 --> 00:22:31,638
FIRST GRADE ACTUALLY MEET THE 

536
00:22:31,638 --> 00:22:34,741
CRITERIA FOR FETAL ALCOHOL 

537
00:22:34,741 --> 00:22:35,742
SPECTRUM DISORDER.

538
00:22:35,742 --> 00:22:36,910
WHAT ABOUT RESEARCH ON ALCOHOL 

539
00:22:36,910 --> 00:22:40,647
AND WHOLE PERSON HEALTH?

540
00:22:40,647 --> 00:22:42,249
WELL, I HAVE ALREADY MENTIONED 

541
00:22:42,249 --> 00:22:43,784
THIS, A WHOLE PERSON APPROACH 

542
00:22:43,784 --> 00:22:46,153
LOOKS AT THE CONNECTIONS ACROSS 

543
00:22:46,153 --> 00:22:49,756
DOMAINS OF HEALTH TO ADDRESS 

544
00:22:49,756 --> 00:22:52,826
DISEASE AND IMPROVE PREVENTION, 

545
00:22:52,826 --> 00:22:54,161
DIAGNOSE AND TREATMENT 

546
00:22:54,161 --> 00:22:54,461
STRATEGIES.

547
00:22:54,461 --> 00:22:57,564
THESE CAN BE BIOLOGICAL, 

548
00:22:57,564 --> 00:22:59,566
GENETICS CO-OCCURRING 

549
00:22:59,566 --> 00:23:01,601
CONDITIONS, BEHAVIORAL, DIET, 

550
00:23:01,601 --> 00:23:04,171
LIFESTYLE, STRESS, SLEEP.

551
00:23:04,171 --> 00:23:04,971
ENVIRONMENTAL, CONDITIONS PEOPLE

552
00:23:04,971 --> 00:23:07,774
ARE BORN, GROW, LIVE WORK AND 

553
00:23:07,774 --> 00:23:10,010
AGE, COMMUNITY CONNECTIONS, 

554
00:23:10,010 --> 00:23:11,645
SPIRITUALITY AND ACCESS TO CARE 

555
00:23:11,645 --> 00:23:13,647
AND RESOURCES.

556
00:23:13,647 --> 00:23:15,749
WE SUPPORT RESEARCH TO IMPROVE 

557
00:23:15,749 --> 00:23:17,317
THE IMPLEMENTATION OF ALCOHOL 

558
00:23:17,317 --> 00:23:18,985
SCREENING, BRIEF INTERVENTION 

559
00:23:18,985 --> 00:23:21,355
AND REFERRAL TO TREATMENT INTO 

560
00:23:21,355 --> 00:23:22,155
ROUTINE HEALTH CARE.

561
00:23:22,155 --> 00:23:25,759
WE ARE GETTING SCREENING.

562
00:23:25,759 --> 00:23:27,494
IT IS PROBABLY ON AVERAGE NOW 

563
00:23:27,494 --> 00:23:30,564
ABOUT 70% OF PRIMARY CARE 

564
00:23:30,564 --> 00:23:33,633
DOCTORS OR HEALTH PROVIDERS ARE 

565
00:23:33,633 --> 00:23:35,335
ASKING PEOPLE HOW MUCH THEY 

566
00:23:35,335 --> 00:23:36,470
DRINK.

567
00:23:36,470 --> 00:23:38,705
UNFORTUNATELY, THAT IS WHERE IT 

568
00:23:38,705 --> 00:23:38,905
ENDS.

569
00:23:38,905 --> 00:23:39,973
A BRIEF INTERVENTION SO THAT IS 

570
00:23:39,973 --> 00:23:42,209
AN AREA WE ARE FOCUSING ON.

571
00:23:42,209 --> 00:23:47,180
WE ARE TRYING TO INTEGRATE 

572
00:23:47,180 --> 00:23:48,215
TREATMENT STRATEGIES FOR 

573
00:23:48,215 --> 00:23:50,150
MULTIPLE ALCOHOL DISORDERS, 

574
00:23:50,150 --> 00:23:54,454
UNCOVER THE MECHANISMS ALCOHOL 

575
00:23:54,454 --> 00:23:57,057
CONTRIBUTES TO DISEASES ACROSS 

576
00:23:57,057 --> 00:23:59,059
THE BODY.

577
00:23:59,059 --> 00:24:00,827
OUR COLLABORATIVE RESEARCH HOLD 

578
00:24:00,827 --> 00:24:02,662
PROMISE FOR ENHANCING THE 

579
00:24:02,662 --> 00:24:04,231
UNDERSTANDING OF WHOLE PERSON 

580
00:24:04,231 --> 00:24:08,702
HEALTH AND IMPROVING SUBSTANCE 

581
00:24:08,702 --> 00:24:10,070
MISUSE-RELATED HEALTH OUTCOMES.

582
00:24:10,070 --> 00:24:11,805
SO WE HAVE BEEN PUSHING A 

583
00:24:11,805 --> 00:24:13,607
CONCEPT WE CALL TREATING ALCOHOL

584
00:24:13,607 --> 00:24:15,375
USE AS A VITAL SIGN.

585
00:24:15,375 --> 00:24:17,978
WE BELIEVE THAT CAN IMPROVE 

586
00:24:17,978 --> 00:24:19,746
OVERALL HEALTH AND I HAVE BEEN 

587
00:24:19,746 --> 00:24:20,414
HINTING AT IT THROUGHOUT THIS 

588
00:24:20,414 --> 00:24:22,015
PRESENTATION SO FAR.

589
00:24:22,015 --> 00:24:24,918
IT IS AN UNDERAPPRECIATED 

590
00:24:24,918 --> 00:24:26,853
CONTRIBUTOR TO MANY HEALTH 

591
00:24:26,853 --> 00:24:29,055
CONDITIONS AND OFTEN OVERLOOKED 

592
00:24:29,055 --> 00:24:31,625
BY HEALTH PROFESSIONALS IN 

593
00:24:31,625 --> 00:24:32,292
PRIMARY CARE AND OTHER HEALTH 

594
00:24:32,292 --> 00:24:33,560
CARE SETTINGS.

595
00:24:33,560 --> 00:24:35,862
APPROACHING ALCOHOL USE IS A 

596
00:24:35,862 --> 00:24:38,398
VITAL SIGN IN IMPROVING 

597
00:24:38,398 --> 00:24:40,467
IMPLEMENTATION OF ALCOHOL 

598
00:24:40,467 --> 00:24:41,735
SCREENINGS, BRIEF INTERVENTION 

599
00:24:41,735 --> 00:24:43,303
AND REFERRAL TO TREATMENT AND 

600
00:24:43,303 --> 00:24:45,038
ROUTINE CARE CAN INCREASE THE 

601
00:24:45,038 --> 00:24:46,573
CHANCES AN ALCOHOL-RELATED 

602
00:24:46,573 --> 00:24:48,675
PROBLEM IS IDENTIFIED AND 

603
00:24:48,675 --> 00:24:49,075
ADDRESSED EARLY.

604
00:24:49,075 --> 00:24:51,278
I SAID BEFORE, IT CAN BE A 

605
00:24:51,278 --> 00:24:52,312
WINDOW ON OTHER CONDITIONS THAT 

606
00:24:52,312 --> 00:24:55,715
YOU MAY HAVE COME TO SEE YOUR 

607
00:24:55,715 --> 00:24:58,018
HEALTH CARE PROVIDER FOR.

608
00:24:58,018 --> 00:24:59,786
SCREENING FOR ALCOHOL USE CAN --

609
00:24:59,786 --> 00:25:01,721
I JUST SAID THAT.

610
00:25:01,721 --> 00:25:03,590
APPROACHING ALCOHOL USE AS A 

611
00:25:03,590 --> 00:25:06,693
VITAL SIGN CAN ALSO REDUCE 

612
00:25:06,693 --> 00:25:08,862
STIGMA.

613
00:25:08,862 --> 00:25:17,304
SO SUPPORTED BY NIAAA, KAISER 

614
00:25:17,304 --> 00:25:19,873
PERMANENTE CALIFORNIA INTRODUCED

615
00:25:19,873 --> 00:25:23,643
UNHEALTHY DRINKING SCREENING 

616
00:25:23,643 --> 00:25:23,877
PROCESS.

617
00:25:23,877 --> 00:25:25,212
THEIR TAGLINE WAS WE SCREEN 

618
00:25:25,212 --> 00:25:25,479
EVERYONE.

619
00:25:25,479 --> 00:25:28,114
IT NORMALIZED WHAT CAN BE A 

620
00:25:28,114 --> 00:25:30,484
SENSITIVE SUBJECT.

621
00:25:30,484 --> 00:25:31,585
ALCOHOL SCREENING AND BRIEF 

622
00:25:31,585 --> 00:25:32,752
INTERVENTION SIGNIFICANTLY 

623
00:25:32,752 --> 00:25:35,922
IMPROVED DRINKING OUTCOMES.

624
00:25:35,922 --> 00:25:38,892
REDUCED NOT ONLY ALCOHOL USE, 

625
00:25:38,892 --> 00:25:43,530
BUT ALSO BLOOD PRESSURE AMONG 

626
00:25:43,530 --> 00:25:46,099
PATIENTS WITH HYPERTENSION.

627
00:25:46,099 --> 00:25:50,170
DAVID GOLMAN HAS CREATED A 

628
00:25:50,170 --> 00:25:51,438
SCREENING FOR EVERYONE WHO COMES

629
00:25:51,438 --> 00:25:53,507
IN THE NIH CLINICAL CENTER.

630
00:25:53,507 --> 00:25:54,975
WE ARE MAKING SOME PROGRESS IN 

631
00:25:54,975 --> 00:25:55,976
THIS DOMAIN.

632
00:25:55,976 --> 00:25:58,645
WE HOPE IT WILL BE EXTENDED.

633
00:25:58,645 --> 00:26:01,014
WE ARE VERY PROUD OF OUR 

634
00:26:01,014 --> 00:26:07,754
INTERACTION WITH HEPATOLO GISS.

635
00:26:07,754 --> 00:26:09,389
INTEGRATED TREATMENT OF ALCOHOL 

636
00:26:09,389 --> 00:26:10,924
ASSOCIATED LIVER DISEASE CAN 

637
00:26:10,924 --> 00:26:12,492
IMPROVE PATIENT OUTCOMES.

638
00:26:12,492 --> 00:26:14,294
MOST OF YOU ARE PROBABLY SAYING 

639
00:26:14,294 --> 00:26:17,197
DUH, BUT IT HAS REALLY NOT BEEN 

640
00:26:17,197 --> 00:26:20,066
DONE UNTIL VERY RECENTLY.

641
00:26:20,066 --> 00:26:20,700
TREATING ALCOHOL USE DISORDER 

642
00:26:20,700 --> 00:26:23,803
WITH MEDICATIONS REDUCES THE 

643
00:26:23,803 --> 00:26:26,740
LIKELIHOOD OF DEVELOPING AN 

644
00:26:26,740 --> 00:26:30,410
ALCOHOL ASSOCIATED LIVER DISEASE

645
00:26:30,410 --> 00:26:32,846
AND REDUCES IF PROGRESSION OF 

646
00:26:32,846 --> 00:26:35,549
EXISTING ALCOHOL LIVER DISEASE.

647
00:26:35,549 --> 00:26:39,352
AFTER DISCHARGE FROM 

648
00:26:39,352 --> 00:26:41,154
HOSPITALIZATION FOR ALCOHOL 

649
00:26:41,154 --> 00:26:42,589
ASSOCIATED LIVER DISEASE REDUCES

650
00:26:42,589 --> 00:26:43,590
READMISSION AND DEATH.

651
00:26:43,590 --> 00:26:46,927
IN 2022 WE SPONSORED A WORKSHOP 

652
00:26:46,927 --> 00:26:49,095
TO BRING TOGETHER ALCOHOL 

653
00:26:49,095 --> 00:26:50,096
ASSOCIATED LIVER DISEASE 

654
00:26:50,096 --> 00:26:53,199
RESEARCHERS AND SPECIALISTS TO 

655
00:26:53,199 --> 00:26:56,570
INFORM IMPROVED INTEGRATIVE CARE

656
00:26:56,570 --> 00:26:58,905
WITH PATIENTS WITH ALD.

657
00:26:58,905 --> 00:27:00,707
THIS LED THE GROUNDWORK FOR 

658
00:27:00,707 --> 00:27:02,108
FUTURE CLINICAL TRIALS FOCUSED 

659
00:27:02,108 --> 00:27:04,377
ON EVALUATING THE IMPACT OF 

660
00:27:04,377 --> 00:27:07,547
INTEGRATED CARE.

661
00:27:07,547 --> 00:27:08,214
THE RESULTING RECOMMENDATIONS 

662
00:27:08,214 --> 00:27:11,217
WERE PUBLISHED LAST YEAR AND ARE

663
00:27:11,217 --> 00:27:13,520
BEING IMPLEMENTED ACROSS OUR 

664
00:27:13,520 --> 00:27:13,787
PORTFOLIO.

665
00:27:13,787 --> 00:27:24,230
AND THIS IS A REFERENCE TO THAT 

666
00:27:24,230 --> 00:27:30,503
PAPER THAT -- I WANT TO REMIND 

667
00:27:30,503 --> 00:27:37,410
YOU OF RETHINKING DRINKING.

668
00:27:37,410 --> 00:27:38,044
COLLEGE AIM.

669
00:27:38,044 --> 00:27:40,780
A RESOURCE FOR COLLEGE 

670
00:27:40,780 --> 00:27:41,147
ENVIRONMENTS.

671
00:27:41,147 --> 00:27:44,484
IT SHOULD BE AVAILABLE TO EVERY 

672
00:27:44,484 --> 00:27:45,819
COLLEGE AND UNIVERSITY IN THE 

673
00:27:45,819 --> 00:27:46,052
COUNTRY.

674
00:27:46,052 --> 00:27:48,321
IF YOU ARE SENDING JOHNNY AND 

675
00:27:48,321 --> 00:27:50,557
SALARY TO A UNIVERSITY OR 

676
00:27:50,557 --> 00:27:54,694
COLLEGE, YOU MIGHT ASK THE 

677
00:27:54,694 --> 00:27:56,696
POWERS THAT BE WHAT PREVENTION 

678
00:27:56,696 --> 00:27:59,599
PROGRAMS THEY ARE USING.

679
00:27:59,599 --> 00:28:02,569
IT HELPS THEM UNDERSTAND WHAT 

680
00:28:02,569 --> 00:28:04,204
RESOURCES MIGHT BE AND TREATMENT

681
00:28:04,204 --> 00:28:07,407
OPTIONS IN THEIR LOCAL ZIP CODE.

682
00:28:07,407 --> 00:28:09,476
HEALTH CARE PROFESSIONALS CORE 

683
00:28:09,476 --> 00:28:10,343
RESOURCES AND EDUCATIONAL 

684
00:28:10,343 --> 00:28:12,812
RESOURCES THAT COVERS THE BASICS

685
00:28:12,812 --> 00:28:14,247
OF WHAT EVERY PROFESSIONAL NEEDS

686
00:28:14,247 --> 00:28:15,649
TO KNOW ABOUT ALCOHOL.

687
00:28:15,649 --> 00:28:17,584
IT INCLUDES INFORMATION ON 

688
00:28:17,584 --> 00:28:19,519
ALCOHOL AND HEALTH, STRATEGIES 

689
00:28:19,519 --> 00:28:30,063
AND SCREENING AND INTERVENTIONS.

690
00:28:31,798 --> 00:28:36,202
IT INCLUDES SCREENINGS.

691
00:28:36,202 --> 00:28:42,709
FOR PROVIDERS WHO ARE NOT 

692
00:28:42,709 --> 00:28:44,110
ALCOHOL SPECIALISTS THEY CAN 

693
00:28:44,110 --> 00:28:46,479
OVERCOME BARRIERS TO CARE FOR 

694
00:28:46,479 --> 00:28:49,115
PATIENTS WITH ALCOHOL PROBLEMS, 

695
00:28:49,115 --> 00:28:50,984
INCLUDING WAYS TO COUNTERACT 

696
00:28:50,984 --> 00:28:52,886
STIGMA IN THEIR PRACTICE.

697
00:28:52,886 --> 00:28:55,088
IT WAS DEVELOPED WITH INPUT FROM

698
00:28:55,088 --> 00:28:59,159
70 CONTRIBUTORS.

699
00:28:59,159 --> 00:28:59,559
.

700
00:28:59,559 --> 00:29:01,227
IT IS EVERYTHING YOU WANTED TO 

701
00:29:01,227 --> 00:29:02,028
KNOW ABOUT ALCOHOL AND WERE 

702
00:29:02,028 --> 00:29:04,564
AFRAID TO ASK.

703
00:29:04,564 --> 00:29:05,098
THANK YOU VERY MUCH.

704
00:29:05,098 --> 00:29:07,467
WE'D LIKE TO BE YOUR SOURCE FOR 

705
00:29:07,467 --> 00:29:10,003
CREDIBLE EVIDENCE-BASED 

706
00:29:10,003 --> 00:29:10,937
INFORMATION ABOUT ALCOHOL AND 

707
00:29:10,937 --> 00:29:11,171
HEALTH.

708
00:29:11,171 --> 00:29:13,707
I WANT TO GIVE A SPECIAL THANKS 

709
00:29:13,707 --> 00:29:22,549
TO DEN POLT LAURA, LAURA AND 

710
00:29:22,549 --> 00:29:25,018
TRISH FOR THEIR HELP WITH THESE 

711
00:29:25,018 --> 00:29:25,685
SLIDES.

712
00:29:25,685 --> 00:29:28,221
THANKS A LOT, EVERYBODY.

713
00:29:28,221 --> 00:29:30,223
SHOULD WE JUST MOVE ON OR DO YOU

714
00:29:30,223 --> 00:29:32,726
WANT TO OPEN FOR QUESTIONS.

715
00:29:32,726 --> 00:29:35,395
>> YES, 10 MINUTES FOR
Q&A.

716
00:29:35,395 --> 00:29:36,696
SO THERE IS TIME.

717
00:29:36,696 --> 00:29:38,598
>> I'M HAPPY TO ANSWER ANY

718
00:29:38,598 --> 00:29:40,133
QUESTIONS IF ANYBODY HAS ANY 

719
00:29:40,133 --> 00:29:42,235
QUESTIONS, PLEASE IF YOU HAVE 

720
00:29:42,235 --> 00:29:49,509
QUESTIONS, HOW DO THAT DO IT 

721
00:29:49,509 --> 00:29:52,212
ONLINE?

722
00:29:52,212 --> 00:29:54,814
THEY RAISE THEIR HAND.

723
00:29:54,814 --> 00:30:01,154
>> WE HAVE A QUESTION FROM
KAREN

724
00:30:01,154 --> 00:30:02,222
EMMONDS.

725
00:30:02,222 --> 00:30:04,824
>> I DO A LOT OF WORK WITH

726
00:30:04,824 --> 00:30:05,892
COMMUNITY HEALTH CENTERS AND 

727
00:30:05,892 --> 00:30:08,228
THEY PUT ENERGIES INTO 

728
00:30:08,228 --> 00:30:10,096
NECESSITIES FOR REQUIRED 

729
00:30:10,096 --> 00:30:11,297
REPORTING METRICS LIKE THERE IS 

730
00:30:11,297 --> 00:30:12,699
FOR TOBACCO SCREENING AND OTHER 

731
00:30:12,699 --> 00:30:12,932
THINGS.

732
00:30:12,932 --> 00:30:14,801
I'M WONDERING IF THERE IS ANY 

733
00:30:14,801 --> 00:30:19,139
MOVEMENT TOWARDS WORKING WITH 

734
00:30:19,139 --> 00:30:22,575
HHS AND HRSA AROUND TRYING TO 

735
00:30:22,575 --> 00:30:24,310
DEVELOP A METRIC HEALTH CENTERS,

736
00:30:24,310 --> 00:30:25,578
WHICH SERVE A TREMENDOUS AMOUNT 

737
00:30:25,578 --> 00:30:27,480
OF PEOPLE ACROSS THE COUNTRY, 

738
00:30:27,480 --> 00:30:31,151
MIGHT HAVE SOME REQUIREMENTS FOR

739
00:30:31,151 --> 00:30:32,118
SCREENING FOR ALCOHOL?

740
00:30:32,118 --> 00:30:34,454
>> THAT IS A REALLY GOOD 

741
00:30:34,454 --> 00:30:34,721
QUESTION.

742
00:30:34,721 --> 00:30:37,524
WE WERE WORKS WITH SAMHSA ON 

743
00:30:37,524 --> 00:30:42,862
THIS ISSUE PRIOR TO THE 

744
00:30:42,862 --> 00:30:44,931
TRANSITION PERIOD AND WHEN I MET

745
00:30:44,931 --> 00:30:48,701
WITH DR. BHATTACHARYA WE DID 

746
00:30:48,701 --> 00:30:50,103
DISCUSS WORKING WITH OTHER 

747
00:30:50,103 --> 00:30:52,205
AGENCIES IN THIS REGARD AND HE 

748
00:30:52,205 --> 00:30:55,375
SAID HE WOULD PROVIDE AS MUCH 

749
00:30:55,375 --> 00:30:58,478
HELP AS I NEEDED.

750
00:30:58,478 --> 00:31:00,213
I'M WAITING FOR OTHER THINGS TO 

751
00:31:00,213 --> 00:31:01,447
SETTLE DOWN AND SEE WHERE OUR 

752
00:31:01,447 --> 00:31:04,184
OTHER AGENCIES LAND.

753
00:31:04,184 --> 00:31:07,020
I WOULD INVITE ALL OF US AT CRAN

754
00:31:07,020 --> 00:31:11,758
WORKING WITH HRSA AND SAMHSA, I 

755
00:31:11,758 --> 00:31:14,561
BELIEVE SAMHSA MOVED IN MAHA 

756
00:31:14,561 --> 00:31:14,828
UMBRELLA.

757
00:31:14,828 --> 00:31:17,263
IT IS A REALLY GOOD QUESTION AND

758
00:31:17,263 --> 00:31:17,964
GOOD POINT.

759
00:31:17,964 --> 00:31:20,667
SOME OF YOU KNOW, I'M IR 

760
00:31:20,667 --> 00:31:23,703
REPRESSABLE WHEN IT COMES TO THE

761
00:31:23,703 --> 00:31:24,037
AUDIT C.

762
00:31:24,037 --> 00:31:26,873
SO ALL MY FELLOW IC DIRECTORS 

763
00:31:26,873 --> 00:31:29,309
HATE ME BECAUSE I TRY TO PUT IT 

764
00:31:29,309 --> 00:31:30,543
IN EVERY COHORT AT NIH.

765
00:31:30,543 --> 00:31:32,412
I THINK I HAVE BEEN SUCCESSFUL, 

766
00:31:32,412 --> 00:31:36,349
ACTUALLY.

767
00:31:36,349 --> 00:31:37,951
ANY OTHER THOUGHTS OR QUESTIONS.

768
00:31:37,951 --> 00:31:43,656
THAT WAS A REALLY GOOD QUESTION.

769
00:31:43,656 --> 00:31:47,894
>> WE HAVE A QUESTION FROM

770
00:31:47,894 --> 00:31:49,462
CHRISTIAN DUARTE.

771
00:31:49,462 --> 00:31:50,163
>> HI.

772
00:31:50,163 --> 00:31:51,631
THANK YOU FOR THIS PRESENTATION.

773
00:31:51,631 --> 00:31:53,600
I WAS CURIOUS ABOUT THE 

774
00:31:53,600 --> 00:31:56,202
INFORMATION ABOUT BING DRINKING 

775
00:31:56,202 --> 00:31:58,504
AND ALCOHOL CONSUMPTION DURING 

776
00:31:58,504 --> 00:31:58,771
PREGNANCY.

777
00:31:58,771 --> 00:32:00,573
IT LOOKS LIKE IT IS GOING UP 

778
00:32:00,573 --> 00:32:00,840
ALSO.

779
00:32:00,840 --> 00:32:04,544
ARE YOU AWARE OF ANY 

780
00:32:04,544 --> 00:32:05,879
INTERVENTIONS SPECIFICALLY FOR 

781
00:32:05,879 --> 00:32:09,282
THIS PERIOD THAT HAVE BEEN 

782
00:32:09,282 --> 00:32:10,450
PARTICULARLY SUCCESSFUL AND ANY 

783
00:32:10,450 --> 00:32:13,887
THOUGHTS YOU MAY HAVE ABOUT THIS

784
00:32:13,887 --> 00:32:14,387
INCREASE.

785
00:32:14,387 --> 00:32:16,956
>> BILL, I HATE TO PUT YOU
ON 

786
00:32:16,956 --> 00:32:18,791
THE SPOT, BUT COULD YOU COME UP 

787
00:32:18,791 --> 00:32:21,060
TO THE MICROPHONE AND ANSWER.

788
00:32:21,060 --> 00:32:23,396
WHAT ARE WE DOING ABOUT PREGNANT

789
00:32:23,396 --> 00:32:24,864
WOMEN?

790
00:32:24,864 --> 00:32:27,000
>> SURE.

791
00:32:27,000 --> 00:32:33,039
>> THIS IS BILL DUNTE, 

792
00:32:33,039 --> 00:32:35,375
COORDINATOR FOR FETAL ALCOHOL 

793
00:32:35,375 --> 00:32:37,043
SPECTRUM DISORDER PORTFOLIO.

794
00:32:37,043 --> 00:32:38,945
>> SCREENING AND BRIEF 

795
00:32:38,945 --> 00:32:40,280
INTERVENTIONS HAVE BEEN MOST 

796
00:32:40,280 --> 00:32:40,580
SUCCESSFUL.

797
00:32:40,580 --> 00:32:45,251
THAT WAS STUDIES THAT THE CDC 

798
00:32:45,251 --> 00:32:51,224
AND NIAAA FUNDED OVER MANY 

799
00:32:51,224 --> 00:32:51,424
YEARS.

800
00:32:51,424 --> 00:32:52,225
I'M NOT SURE.

801
00:32:52,225 --> 00:32:57,063
I MISSED A LITTLE BIT OF YOUR 

802
00:32:57,063 --> 00:32:59,165
QUESTION YOU WERE TALKING ABOUT 

803
00:32:59,165 --> 00:32:59,899
BING DRINKING IN PARTICULAR?

804
00:32:59,899 --> 00:33:00,667
>> YEAH.

805
00:33:00,667 --> 00:33:03,836
SHE SAYS IT LOOKS LIKE IT IS 

806
00:33:03,836 --> 00:33:04,837
GOING UP.

807
00:33:04,837 --> 00:33:05,672
THE QUESTION IS WHAT ARE WE 

808
00:33:05,672 --> 00:33:06,839
DOING IN THE PREVENTION DOMAIN 

809
00:33:06,839 --> 00:33:07,473
FOR THAT?

810
00:33:07,473 --> 00:33:09,309
I KNOW ABOUT THE SCREENING AND 

811
00:33:09,309 --> 00:33:13,079
BRIEF INTERVENTION, BUT DO WE 

812
00:33:13,079 --> 00:33:16,416
HAVE ANYTHING REGARDING BING 

813
00:33:16,416 --> 00:33:16,683
DRINKING?

814
00:33:16,683 --> 00:33:18,785
>> MY RECOLLECTION OF THE
DATA 

815
00:33:18,785 --> 00:33:23,823
AND TRENDS FOR BINGE DRINKING 4%

816
00:33:23,823 --> 00:33:25,291
TO 5% OVER SEVERAL YEARS.

817
00:33:25,291 --> 00:33:28,461
ONE OF THE THINGS THAT NIAAA HAS

818
00:33:28,461 --> 00:33:29,829
BEEN DOING OVER THE LAST THREE 

819
00:33:29,829 --> 00:33:30,129
YEARS.

820
00:33:30,129 --> 00:33:32,465
WE DO HAVE A FUNDING OPPORTUNITY

821
00:33:32,465 --> 00:33:35,868
ANNOUNCEMENT LOOKING AT NOVEL 

822
00:33:35,868 --> 00:33:38,304
APPROACHES FOR FASD 

823
00:33:38,304 --> 00:33:39,339
INTERVENTIONS AND PREVENTION 

824
00:33:39,339 --> 00:33:39,706
APPROACHES.

825
00:33:39,706 --> 00:33:42,475
I DON'T HAVE THE NOTICE OFFHAND,

826
00:33:42,475 --> 00:33:46,145
BUT WE CAN PROVIDE THAT 

827
00:33:46,145 --> 00:33:47,680
INFORMATION TO COUNCIL.

828
00:33:47,680 --> 00:33:49,515
AND THE NOTICE HAS BEEN OUT ON 

829
00:33:49,515 --> 00:33:51,551
THE STREETS FOR ABOUT THREE 

830
00:33:51,551 --> 00:33:51,751
YEARS.

831
00:33:51,751 --> 00:33:55,054
WE'VE HAD A FEW NOVEL APPROACHES

832
00:33:55,054 --> 00:33:57,290
APPLICATIONS COME IN THAT WE 

833
00:33:57,290 --> 00:33:57,657
FUNDED.

834
00:33:57,657 --> 00:34:00,860
AND WE'VE REISSUED THAT FUNDING 

835
00:34:00,860 --> 00:34:03,463
OPPORTUNITY FOR ANOTHER THREE 

836
00:34:03,463 --> 00:34:03,663
YEARS.

837
00:34:03,663 --> 00:34:05,365
SO HOPEFULLY BASED ON THAT 

838
00:34:05,365 --> 00:34:11,237
ANNOUNCEMENT, WE'LL BE ABLE TO 

839
00:34:11,237 --> 00:34:12,038
ANSWER THAT QUESTION WITH SOME 

840
00:34:12,038 --> 00:34:13,973
NOVEL APPROACHES IN THE FUTURE.

841
00:34:13,973 --> 00:34:16,142
>> JUST TO ADD SOMETHING,
WE 

842
00:34:16,142 --> 00:34:19,579
ALSO HAVE A RESEARCHER WHO IS 

843
00:34:19,579 --> 00:34:21,481
STUDYING POLICY ISSUES AROUND 

844
00:34:21,481 --> 00:34:23,149
PREVENTION OF DRINKING DURING 

845
00:34:23,149 --> 00:34:23,416
PREGNANCY.

846
00:34:23,416 --> 00:34:25,284
AND WHAT WE HAVE TO BE CAREFUL 

847
00:34:25,284 --> 00:34:27,286
IS A POLICY DOESN'T DRIVE A 

848
00:34:27,286 --> 00:34:28,187
WOMAN AWAY FROM HEALTH CARE.

849
00:34:28,187 --> 00:34:31,324
SO IT IS A LITTLE BIT OF A 

850
00:34:31,324 --> 00:34:33,126
BALANCE BETWEEN THE 

851
00:34:33,126 --> 00:34:34,694
INTERVENTIONS WE DO TO PREVENT 

852
00:34:34,694 --> 00:34:36,295
THIS BEHAVIOR, BUT ALSO NOT TO 

853
00:34:36,295 --> 00:34:39,966
DRIVE SOMEBODY AWAY FROM SEEKING

854
00:34:39,966 --> 00:34:40,500
CARE OVERALL.

855
00:34:40,500 --> 00:34:42,568
>> THANKS, TRISH.

856
00:34:42,568 --> 00:34:44,637
>> WE HAVE A QUESTION FROM

857
00:34:44,637 --> 00:34:48,207
ISABELLE DURAN.

858
00:34:48,207 --> 00:34:50,810
>> THANK YOU VERY MUCH.

859
00:34:50,810 --> 00:34:54,881
DR. KOOB WE WORK IN THE LATINO 

860
00:34:54,881 --> 00:34:55,648
COMMUNITY AROUND ISSUES OF 

861
00:34:55,648 --> 00:34:57,817
CANCER AND CONNECTED THE DOTS TO

862
00:34:57,817 --> 00:34:58,885
ALCOHOL, PROBABLY NOT AS MUCH AS

863
00:34:58,885 --> 00:35:02,755
WE SHOULD.

864
00:35:02,755 --> 00:35:04,957
WE DO THIS THROUGH EDUCATION AND

865
00:35:04,957 --> 00:35:07,060
NATIONAL FORUMS THAT WE DO EVERY

866
00:35:07,060 --> 00:35:07,560
YEAR.

867
00:35:07,560 --> 00:35:09,228
I HAVEN'T, SORRY, VISITED YOUR 

868
00:35:09,228 --> 00:35:14,200
SITE AND LOOKED AT THE OTHER 

869
00:35:14,200 --> 00:35:16,202
GROUPS HERE, SO I DON'T KNOW 

870
00:35:16,202 --> 00:35:17,070
WHAT IS AVAILABLE.

871
00:35:17,070 --> 00:35:19,305
MY QUESTION IS CAN I FIND IN 

872
00:35:19,305 --> 00:35:21,841
WHAT IS AVAILABLE ON YOUR 

873
00:35:21,841 --> 00:35:23,709
WEBSITE SPECIFIC KINDS OF 

874
00:35:23,709 --> 00:35:25,711
PRIMERS OR THINGS IN SPANISH I 

875
00:35:25,711 --> 00:35:27,547
CAN PASS ON TO THE VARIOUS 

876
00:35:27,547 --> 00:35:29,182
ORGANIZATIONS WE WORK WITH SO 

877
00:35:29,182 --> 00:35:33,886
THEY CAN PINPOINT AND LOOK AT 

878
00:35:33,886 --> 00:35:35,288
ARE THERE BEST PRACTICES 

879
00:35:35,288 --> 00:35:36,989
PROGRAMS THAT ARE WORKING OUT 

880
00:35:36,989 --> 00:35:38,791
THERE DIRECTED TOWARDS THE 

881
00:35:38,791 --> 00:35:40,226
LATINO COMMUNITY AND CAN BE 

882
00:35:40,226 --> 00:35:41,561
PROVIDED IN SPANISH?

883
00:35:41,561 --> 00:35:43,362
>> THAT IS A REALLY GOOD 

884
00:35:43,362 --> 00:35:45,431
QUESTION AND I DON'T KNOW THE 

885
00:35:45,431 --> 00:35:46,766
ANSWER OFF HAND.

886
00:35:46,766 --> 00:35:48,267
BILL, DOES NCI HAVE SOMETHING --

887
00:35:48,267 --> 00:35:51,104
I KNOW YOU HAVE SOME MATERIAL ON

888
00:35:51,104 --> 00:35:54,040
CANCER, BUT IS ANY OF IT IS 

889
00:35:54,040 --> 00:35:54,273
SPANISH?

890
00:35:54,273 --> 00:35:55,441
>> NOT THAT I KNOW OF.

891
00:35:55,441 --> 00:35:57,443
WE CAN TAKE A LOOK.

892
00:35:57,443 --> 00:35:59,712
THERE IS CLEARLY A NEED FOR MORE

893
00:35:59,712 --> 00:36:06,552
OF IT, NOT JUST IN SPANISH, IN 

894
00:36:06,552 --> 00:36:07,487
ENGLISH.

895
00:36:07,487 --> 00:36:08,821
WE ARE DOING SOME WORK ON 

896
00:36:08,821 --> 00:36:09,222
MESSAGING.

897
00:36:09,222 --> 00:36:10,823
I WILL MENTION THAT IN MY 

898
00:36:10,823 --> 00:36:12,258
PRESENTATION.

899
00:36:12,258 --> 00:36:16,462
WEAPON  -- WE ARE NOT AS FAR 

900
00:36:16,462 --> 00:36:18,731
ALONG WITH ALCOHOL AS WE ARE 

901
00:36:18,731 --> 00:36:19,065
WITH TOBACCO.

902
00:36:19,065 --> 00:36:22,468
>> THIS IS WHAT IS GREAT
ABOUT 

903
00:36:22,468 --> 00:36:22,735
CRAN.

904
00:36:22,735 --> 00:36:25,404
I DON'T HAVE TO SAY I DON'T KNOW

905
00:36:25,404 --> 00:36:26,672
THE ANSWER BECAUSE SOMEBODY IN 

906
00:36:26,672 --> 00:36:27,773
THE ROOM HAS THE ANSWER.

907
00:36:27,773 --> 00:36:29,742
ANY OTHER QUESTIONS.

908
00:36:29,742 --> 00:36:32,044
>> OUR FACT SHEETS ARE IN 

909
00:36:32,044 --> 00:36:34,780
SPANISH AND ENGLISH, BUT DON'T 

910
00:36:34,780 --> 00:36:36,782
GO INTO DEPTH IN TERMS OF THE 

911
00:36:36,782 --> 00:36:37,817
PROGRAM.

912
00:36:37,817 --> 00:36:39,585
BUT WE DO PUT OUT OUR FACT 

913
00:36:39,585 --> 00:36:41,187
SHEETS IN SPANISH AND ENGLISH.

914
00:36:41,187 --> 00:36:42,889
SOME OF THAT IS ACCESSIBLE AND 

915
00:36:42,889 --> 00:36:46,159
WE ARE LOOKING FOR HOW NIH 

916
00:36:46,159 --> 00:36:47,393
DECIDES TO COMMUNICATE OVERALL 

917
00:36:47,393 --> 00:36:51,464
AND WHAT THEY DO IN TERMS OF 

918
00:36:51,464 --> 00:36:51,731
WEBSITES.

919
00:36:51,731 --> 00:36:53,199
>> ANY OTHER THOUGHTS OR 

920
00:36:53,199 --> 00:36:54,901
QUESTIONS FROM ANYBODY REAL 

921
00:36:54,901 --> 00:36:58,604
QUICK?

922
00:36:58,604 --> 00:36:59,505
ALL CLEAR?

923
00:36:59,505 --> 00:36:59,939
OKAY.

924
00:36:59,939 --> 00:37:00,506
THANKS, EVERYONE.

925
00:37:00,506 --> 00:37:04,610
THAT WAS REALLY INTERESTING AND 

926
00:37:04,610 --> 00:37:06,612
WE'VE GOT THINGS THAT WILL BE 

927
00:37:06,612 --> 00:37:17,089
USEFUL FOR FUTURE PLANNING.

928
00:37:24,964 --> 00:37:28,234
ALL RIGHT, SO NOW WE'RE READY TO

929
00:37:28,234 --> 00:37:34,273
HAVE DR. VOLKOW TO PRESENT HER 

930
00:37:34,273 --> 00:37:35,441
NIDA'S DIRECTOR PRESENTATION.

931
00:37:35,441 --> 00:37:37,076
SHE IS THE DIRECTOR OF THE 

932
00:37:37,076 --> 00:37:39,278
NATIONAL INSTITUTE ON DRUG 

933
00:37:39,278 --> 00:37:39,478
ABUSE.

934
00:37:39,478 --> 00:37:40,246
>> YES.

935
00:37:40,246 --> 00:37:41,714
GEORGE, THANKS VERY MUCH.

936
00:37:41,714 --> 00:37:44,183
IT WOULD BE FANTASTIC IF SOMEONE

937
00:37:44,183 --> 00:37:46,018
ALLOWS ME TO SHARE MY 

938
00:37:46,018 --> 00:37:46,752
PRESENTATION.

939
00:37:46,752 --> 00:37:48,621
BECAUSE IN THE MODE I'M IN NOW 

940
00:37:48,621 --> 00:37:52,158
IS NOT LETTING ME SHARE.

941
00:37:52,158 --> 00:37:56,729
IS SOMEONE IN IT CAN LOOK INTO 

942
00:37:56,729 --> 00:37:58,731
WHY I CANNOT SHARE?

943
00:37:58,731 --> 00:37:59,532
>> YES.

944
00:37:59,532 --> 00:38:02,735
GIVE ME A FEW SECONDS AND I WILL

945
00:38:02,735 --> 00:38:04,737
ALLOW YOU TO DO THAT.

946
00:38:04,737 --> 00:38:08,441
>> AS DR. KOOB WAS
SPEAKING, I 

947
00:38:08,441 --> 00:38:10,009
CHANGED MY PRESENTATION TO 

948
00:38:10,009 --> 00:38:12,511
CONFORM TO NARRATIVE ISSUES.

949
00:38:12,511 --> 00:38:13,946
>> I JUST CHANGED IT.

950
00:38:13,946 --> 00:38:15,114
IT SHOULD BE OKAY.

951
00:38:15,114 --> 00:38:18,551
>> FANTASTIC.

952
00:38:18,551 --> 00:38:19,352
LET ME SHARE.

953
00:38:19,352 --> 00:38:22,021
AND WHAT I'M GOING TO BE DOING 

954
00:38:22,021 --> 00:38:32,565
RIGHT NOW, OBVIOUSLY, LET ME 

955
00:38:35,067 --> 00:38:35,167
SEE.

956
00:38:35,167 --> 00:38:36,535
>> IT'S UP, NORAH.

957
00:38:36,535 --> 00:38:37,470
>> OKAY.

958
00:38:37,470 --> 00:38:37,937
IT'S THERE?

959
00:38:37,937 --> 00:38:39,672
>> PERFECT.

960
00:38:39,672 --> 00:38:40,673
>> OKAY.

961
00:38:40,673 --> 00:38:42,508
SO WHAT I'M GOING TO TRY TO DO 

962
00:38:42,508 --> 00:38:44,577
TODAY BECAUSE I GAVE A 

963
00:38:44,577 --> 00:38:45,511
PRESENTATION YESTERDAY TO OUR 

964
00:38:45,511 --> 00:38:50,983
COUNCIL IS TO ACTUALLY IDENTIFY 

965
00:38:50,983 --> 00:38:52,918
RELEVANT TOPICS FOR THE THREE OF

966
00:38:52,918 --> 00:38:54,887
OUR INSTITUTES AND I GUESS IF 

967
00:38:54,887 --> 00:38:57,690
THERE IS A MESSAGE IN MY BRAIN 

968
00:38:57,690 --> 00:39:00,893
IS THAT WE NEED TO START TO 

969
00:39:00,893 --> 00:39:04,196
SHIFT THE WAY THAT WE DO SCIENCE

970
00:39:04,196 --> 00:39:09,502
AND ANALYZE PROBLEMS AS SORT OF 

971
00:39:09,502 --> 00:39:10,303
SEPARATE CATEGORY.

972
00:39:10,303 --> 00:39:11,971
CERTAINLY IN THE WHOLE FIELD OF 

973
00:39:11,971 --> 00:39:13,406
SUBSTANCE USE THERE ARE NO 

974
00:39:13,406 --> 00:39:15,675
PEOPLE THAT JUST ABUSE ONE DRUG,

975
00:39:15,675 --> 00:39:18,944
ALCOHOL, OR JUST ABUSE TOBACCO.

976
00:39:18,944 --> 00:39:21,180
THAT FREQUENCY WHICH THESE DRUGS

977
00:39:21,180 --> 00:39:23,115
ARE USED TOGETHER IS EXTREMELY 

978
00:39:23,115 --> 00:39:27,119
HIGH, AND YET WE CONTINUE TO 

979
00:39:27,119 --> 00:39:28,854
PERSEVERATE INTO JUST 

980
00:39:28,854 --> 00:39:30,556
IDENTIFYING AND DOING THE 

981
00:39:30,556 --> 00:39:35,695
STUDIES IN SIMPLE MODELS THAT 

982
00:39:35,695 --> 00:39:37,530
DON'T CONVEY THE COMPLEXITY OF 

983
00:39:37,530 --> 00:39:39,432
THE REALITY THAT IS PATIENTS ARE

984
00:39:39,432 --> 00:39:39,765
EXPERIENCING.

985
00:39:39,765 --> 00:39:42,535
AND I THINK THAT PERFECT EXAMPLE

986
00:39:42,535 --> 00:39:44,136
THAT GEORGE BROUGHT UP REGARDING

987
00:39:44,136 --> 00:39:47,106
CANCER ILLUSTRATES THAT VERY 

988
00:39:47,106 --> 00:39:47,306
WELL.

989
00:39:47,306 --> 00:39:49,475
AND CRAN IN A WAY GIVES US THE 

990
00:39:49,475 --> 00:39:51,610
OPPORTUNITY TO DO THIS.

991
00:39:51,610 --> 00:39:54,447
SO MY FIRST -- AND I GAVE THESE 

992
00:39:54,447 --> 00:39:55,381
REPORT CARDS YESTERDAY BECAUSE 

993
00:39:55,381 --> 00:40:00,386
IT WAS VERY RELEVANT FOR BOTH ON

994
00:40:00,386 --> 00:40:01,420
OUR COUNCIL ON CRAN.

995
00:40:01,420 --> 00:40:03,789
THE NOTION OF WHAT IS THE 

996
00:40:03,789 --> 00:40:04,223
STATUS?

997
00:40:04,223 --> 00:40:05,391
THIS IS MONITORING THE FUTURE, 

998
00:40:05,391 --> 00:40:07,860
THE RESULTS FROM LAST YEAR, THAT

999
00:40:07,860 --> 00:40:09,829
ACTUALLY IDENTIFIES AND 

1000
00:40:09,829 --> 00:40:10,996
SUMMARIZES IT HAS BEEN 

1001
00:40:10,996 --> 00:40:13,199
DECREASES, WHICH ARE MARKED HERE

1002
00:40:13,199 --> 00:40:13,999
IN GREEN.

1003
00:40:13,999 --> 00:40:17,636
ON PATTERNS OF DRUG USE OR 

1004
00:40:17,636 --> 00:40:19,905
ALCOHOL BETWEEN 23 AND 24.

1005
00:40:19,905 --> 00:40:22,908
AND SO THESE ARE SIGNIFICANT 

1006
00:40:22,908 --> 00:40:25,644
CHANGES IN A ONE-YEAR PERIOD FOR

1007
00:40:25,644 --> 00:40:30,182
KIDS THAT ARE 8th, 10th, 12th 

1008
00:40:30,182 --> 00:40:30,383
GRADE.

1009
00:40:30,383 --> 00:40:31,984
AND IT RELATES TO DIFFERENT 

1010
00:40:31,984 --> 00:40:35,187
TYPES OF INDICATORS.

1011
00:40:35,187 --> 00:40:37,223
I'M HIGHLIGHTING TO YOUR LEFT 

1012
00:40:37,223 --> 00:40:38,290
ALCOHOL BECAUSE YOU CAN SEE 

1013
00:40:38,290 --> 00:40:41,260
WHETHER IT IS LIFE TIME, PAST 

1014
00:40:41,260 --> 00:40:43,996
YEAR, PAST MONTH, BINGE DRUNK, 

1015
00:40:43,996 --> 00:40:45,498
ALL OF THEM ARE GOING IN THE 

1016
00:40:45,498 --> 00:40:45,898
RIGHT DIRECTION.

1017
00:40:45,898 --> 00:40:47,933
I POINTED THIS OUT BECAUSE THIS 

1018
00:40:47,933 --> 00:40:49,235
IS SOMETHING NOW WE HAVE BEEN 

1019
00:40:49,235 --> 00:40:50,836
SEEING FOR SEVERAL YEARS.

1020
00:40:50,836 --> 00:40:54,974
AND THE SAME THING WITH ELICIT 

1021
00:40:54,974 --> 00:40:55,374
DRUGS.

1022
00:40:55,374 --> 00:40:56,809
THERE ARE SIGNIFICANT PATTERN 

1023
00:40:56,809 --> 00:40:58,711
CHANGES IN THE DRUGS THAT ARE 

1024
00:40:58,711 --> 00:40:59,945
FAVORED BY TEENAGERS AND IN 

1025
00:40:59,945 --> 00:41:02,681
PARTICULAR, WE ARE SEEING A RISE

1026
00:41:02,681 --> 00:41:05,818
OF ALTERNATIVE NICOTINE DELIVERY

1027
00:41:05,818 --> 00:41:08,220
SYSTEMS, PARTICULARLY PROMINENT 

1028
00:41:08,220 --> 00:41:10,523
IS ELECTRONIC CIGARETTES.

1029
00:41:10,523 --> 00:41:11,857
FORTUNATELY, THEY HAVE BEEN 

1030
00:41:11,857 --> 00:41:14,860
GOING DOWN EVEN THOUGH THE 

1031
00:41:14,860 --> 00:41:16,595
PREVALENCE IS EXTREMELY, 

1032
00:41:16,595 --> 00:41:16,962
EXTREMELY HIGH.

1033
00:41:16,962 --> 00:41:21,801
IT IS ONE OF THE MOST PREVALENT 

1034
00:41:21,801 --> 00:41:22,468
DRUGS TEENAGER FAVOR AFTER 

1035
00:41:22,468 --> 00:41:26,272
ALCOHOL AND BY THE SIDE OF 

1036
00:41:26,272 --> 00:41:26,806
MARIJUANA.

1037
00:41:26,806 --> 00:41:28,307
FOR EXAMPLE, WE SEE IN 

1038
00:41:28,307 --> 00:41:32,645
PARTICULAR THERE HAS BEEN A RISE

1039
00:41:32,645 --> 00:41:35,481
IN TANDEM OF NICOTINE POUCHES 

1040
00:41:35,481 --> 00:41:46,025
AND A RISE IN 8th GRADERS OF -- 

1041
00:41:47,493 --> 00:41:49,528
WHICH ARE NICOTINE AND NICOTINE 

1042
00:41:49,528 --> 00:41:51,464
POUCHES ARE PROVIDED WITH 

1043
00:41:51,464 --> 00:41:53,132
FLAVORS WHICH MAKE IT VERY, VERY

1044
00:41:53,132 --> 00:41:54,467
APPEALING FOR TEENAGERS.

1045
00:41:54,467 --> 00:41:56,702
THESE ARE NEW WAYS OF DELIVERY 

1046
00:41:56,702 --> 00:42:04,210
THAT UNFORTUNATELY ARE CHANGING 

1047
00:42:04,210 --> 00:42:09,782
THE ACTIONS OF TEENAGERS WITH 

1048
00:42:09,782 --> 00:42:10,216
NICOTINE.

1049
00:42:10,216 --> 00:42:13,452
IT PUTS THEM INTO LATER ON 

1050
00:42:13,452 --> 00:42:14,720
TRANSITIONING INTO TOBACCO 

1051
00:42:14,720 --> 00:42:16,055
PRODUCTS, BUT EVEN BY ITSELF 

1052
00:42:16,055 --> 00:42:19,992
THAT USE OF NICOTINE HAS BEEN 

1053
00:42:19,992 --> 00:42:26,432
CLEARLY ASSOCIATED WITH RISKS.

1054
00:42:26,432 --> 00:42:26,999
HERE IS ILLUSTRATED IN A 

1055
00:42:26,999 --> 00:42:28,734
DIFFERENT WAY.

1056
00:42:28,734 --> 00:42:33,038
THIS IS A TRENDS IN LIFE TIME 

1057
00:42:33,038 --> 00:42:36,108
PREVALENCE FOR THE PERCENT OF 

1058
00:42:36,108 --> 00:42:38,544
INDIVIDUALS WHO USE BY GRADE.

1059
00:42:38,544 --> 00:42:40,212
SO LIFE TIME.

1060
00:42:40,212 --> 00:42:42,481
SO YOU CAN SEE INTERESTINGLY, 

1061
00:42:42,481 --> 00:42:44,617
THIS IS JUST FOR 12th GRADERS, 

1062
00:42:44,617 --> 00:42:46,852
FOR ALCOHOL AND FOR CIGARETTES, 

1063
00:42:46,852 --> 00:42:51,156
THE NUMBER OF INDIVIDUALS HAS 

1064
00:42:51,156 --> 00:42:52,691
BEEN GOING DOWN.

1065
00:42:52,691 --> 00:42:55,794
WHEREAS IN 1979, WE COULD HAVE 

1066
00:42:55,794 --> 00:42:58,731
90% OF THE 12th GRADERS THAT HAD

1067
00:42:58,731 --> 00:43:02,001
USED ALCOHOL ONCE IN THEIR 

1068
00:43:02,001 --> 00:43:04,370
LIFETIME, WE HAVE NOW BASICALLY 

1069
00:43:04,370 --> 00:43:04,937
60%.

1070
00:43:04,937 --> 00:43:06,972
THIS IS PRETTY STRIKING 

1071
00:43:06,972 --> 00:43:11,644
REDUCTIONS CONSIDERING THIS IS 

1072
00:43:11,644 --> 00:43:12,978
LIFETIME PREVALENCE.

1073
00:43:12,978 --> 00:43:15,781
THE NUMBER OF THEM ARE 8th 

1074
00:43:15,781 --> 00:43:18,050
GRADERS, ACTUALLY MUCH SMALLER, 

1075
00:43:18,050 --> 00:43:19,151
BUT EVERYTHING IS GOING IN THE 

1076
00:43:19,151 --> 00:43:20,019
RIGHT DIRECTION.

1077
00:43:20,019 --> 00:43:21,787
THE SAME THING IN CIGARETTES.

1078
00:43:21,787 --> 00:43:23,489
AT ONE POINT IT WAS ESTIMATED 

1079
00:43:23,489 --> 00:43:26,525
THAT 70% OF 12th GRADERS WOULD 

1080
00:43:26,525 --> 00:43:28,794
HAVE SMOKED CIGARETTES IN THEIR 

1081
00:43:28,794 --> 00:43:33,899
LIVES THERE -- LIFETIME.

1082
00:43:33,899 --> 00:43:35,568
IT IS LESS THAN 20%.

1083
00:43:35,568 --> 00:43:38,437
IT IS GOING DOWN.

1084
00:43:38,437 --> 00:43:44,610
NICOTINE VAPING IS GOING DOWN, 

1085
00:43:44,610 --> 00:43:47,446
BUT STILL SEE APPROXIMATELY 60% 

1086
00:43:47,446 --> 00:43:52,518
OF TEENAGERS, 12 OR IS 11th 

1087
00:43:52,518 --> 00:43:53,953
GRADE HAVE EXPERIENCE WITH 

1088
00:43:53,953 --> 00:43:54,720
VAPING.

1089
00:43:54,720 --> 00:43:58,490
THIS REFLECTS THE PATTERN 

1090
00:43:58,490 --> 00:43:59,325
BEHAVIORAL CHANGES THAT MAKE 

1091
00:43:59,325 --> 00:44:00,759
CERTAIN PRODUCTS MUCH MORE 

1092
00:44:00,759 --> 00:44:02,761
APPEALING TO TEENAGERS AND 

1093
00:44:02,761 --> 00:44:02,995
OTHERS.

1094
00:44:02,995 --> 00:44:03,896
I SUSPECT ALL THE COMMERCIAL 

1095
00:44:03,896 --> 00:44:05,030
INTERESTS THAT ARE MAKING THIS 

1096
00:44:05,030 --> 00:44:07,900
HAPPEN.

1097
00:44:07,900 --> 00:44:09,034
BECAUSE THIS IS A REALITY WE ARE

1098
00:44:09,034 --> 00:44:12,204
NOW FACED WITH THE NOTION OF HOW

1099
00:44:12,204 --> 00:44:16,208
DO WE TREAT TEENAGERS THAT HAVE 

1100
00:44:16,208 --> 00:44:17,509
NICOTINE ADDICTION?

1101
00:44:17,509 --> 00:44:21,580
AND THAT WE DON'T EVEN HAVE FOR 

1102
00:44:21,580 --> 00:44:22,915
TREATMENTS THAT WORK FOR TOBACCO

1103
00:44:22,915 --> 00:44:24,316
ADDICTION IN ADOLESCENTS.

1104
00:44:24,316 --> 00:44:27,119
BECAUSE THE MEDICATIONS THAT WE 

1105
00:44:27,119 --> 00:44:29,088
USUALLY USE, HAVE NOT BEEN SHOWN

1106
00:44:29,088 --> 00:44:31,290
TO BE EFFECTIVE IN THE TREATMENT

1107
00:44:31,290 --> 00:44:32,491
OF TEENAGERS.

1108
00:44:32,491 --> 00:44:34,893
SO AN AREA OF TREMENDOUS 

1109
00:44:34,893 --> 00:44:40,933
IMPORTANCE IS, AGAIN, RESEARCH.

1110
00:44:40,933 --> 00:44:42,601
OTHER THINGS THAT CAN HELP 

1111
00:44:42,601 --> 00:44:45,037
TEENAGERS, ADOLESCENTS BASICALLY

1112
00:44:45,037 --> 00:44:47,673
OVERCOME ADDICTION TO VAPING 

1113
00:44:47,673 --> 00:44:49,708
NICOTINE, WHICH IS THE MOST 

1114
00:44:49,708 --> 00:44:50,776
PREVALENT ONE OF THEM.

1115
00:44:50,776 --> 00:44:52,511
THIS IS THE FIRST STUDY I'M 

1116
00:44:52,511 --> 00:44:54,747
AWARE OF, RANDOMIZED CLINICAL 

1117
00:44:54,747 --> 00:44:58,884
TRIAL THAT EVALUATES AND SHOWS 

1118
00:44:58,884 --> 00:45:04,456
EFFECTIVENESS FOR VERENICLYN IN 

1119
00:45:04,456 --> 00:45:09,461
TEENAGERS THAT HAVE A -- 

1120
00:45:09,461 --> 00:45:12,197
VARENICLINE IN TEENAGE 

1121
00:45:12,197 --> 00:45:14,767
ADDICTION.

1122
00:45:14,767 --> 00:45:16,802
VARENICLINE IS NOT EFFECTIVE 

1123
00:45:16,802 --> 00:45:19,371
WHEN YOU LOOK AT TOBACCO IN 

1124
00:45:19,371 --> 00:45:20,205
ADOLESCENTS.

1125
00:45:20,205 --> 00:45:22,274
THERE IS A DURING RATION THAT IT

1126
00:45:22,274 --> 00:45:25,644
WAS GIVEN IN THE STUDY THAT 

1127
00:45:25,644 --> 00:45:27,913
COULD ACCOUNT FOR THESE POSITIVE

1128
00:45:27,913 --> 00:45:28,147
RESULTS.

1129
00:45:28,147 --> 00:45:30,616
BUT IT DOES INDICATE THE EXTENT 

1130
00:45:30,616 --> 00:45:34,319
TO WHICH THIS CAN BE REPRODUCED 

1131
00:45:34,319 --> 00:45:36,388
AND REPLICATABLE.

1132
00:45:36,388 --> 00:45:39,792
IT ALLOWS TREATMENT FOR NICOTINE

1133
00:45:39,792 --> 00:45:40,059
ADDICTION.

1134
00:45:40,059 --> 00:45:42,861
IN AS MUCH AS NICOTINE ADDICTION

1135
00:45:42,861 --> 00:45:44,930
HAS BEEN SHOWN BY RESEARCHERS TO

1136
00:45:44,930 --> 00:45:48,434
SERVE AS A GATEWAY DRUG FOR 

1137
00:45:48,434 --> 00:45:50,903
PATTERNS OF USE, INCREASING THE 

1138
00:45:50,903 --> 00:45:54,440
USE OF OTHER SUBSTANCES, 

1139
00:45:54,440 --> 00:45:56,208
INCLUDING ILLICIT SUBSTANCES 

1140
00:45:56,208 --> 00:45:59,344
THEN CAN BE OBSERVED FROM THE 

1141
00:45:59,344 --> 00:46:02,147
PERSPECTIVE THESE COULD BE 

1142
00:46:02,147 --> 00:46:04,116
PREVENTION INTERVENTION FOR 

1143
00:46:04,116 --> 00:46:04,917
OTHER SUBSTANCE USE DISORDERS IN

1144
00:46:04,917 --> 00:46:06,652
GENERAL.

1145
00:46:06,652 --> 00:46:09,922
NOW THIS BRINGS ME TO THE 

1146
00:46:09,922 --> 00:46:10,856
QUESTION ABOUT THIS IS 

1147
00:46:10,856 --> 00:46:11,190
TREATMENT.

1148
00:46:11,190 --> 00:46:13,158
BUT THE KEY ELEMENT ON ALL OF 

1149
00:46:13,158 --> 00:46:15,327
THIS IS WHEN SOMEONE NEEDS 

1150
00:46:15,327 --> 00:46:16,161
TREATMENT ALREADY MANY THINGS 

1151
00:46:16,161 --> 00:46:20,032
HAVE HAPPENED AND AGAIN WE 

1152
00:46:20,032 --> 00:46:21,500
ALWAYS TALK ABOUT HOW IMPORTANT 

1153
00:46:21,500 --> 00:46:22,201
IS PREVENTION.

1154
00:46:22,201 --> 00:46:23,902
EVERYBODY SAYS PREVENTION IS THE

1155
00:46:23,902 --> 00:46:26,071
MOST EFFECTIVE INTERVENTION WE 

1156
00:46:26,071 --> 00:46:27,906
HAVE IN HEALTH CARE AND YET IT 

1157
00:46:27,906 --> 00:46:29,641
DOESN'T GET THE ATTENTION IT 

1158
00:46:29,641 --> 00:46:29,908
DESERVES.

1159
00:46:29,908 --> 00:46:32,845
A LOT OF RESEARCH HAS BEEN GOING

1160
00:46:32,845 --> 00:46:34,446
ON IN TERMS OF BASIC FUNDAMENTAL

1161
00:46:34,446 --> 00:46:36,215
SCIENCE TO TRY TO UNDERSTAND 

1162
00:46:36,215 --> 00:46:39,852
WHAT MAKES SOMEONE VULNERABLE TO

1163
00:46:39,852 --> 00:46:41,053
A SUBSTANCE USE DISORDER.

1164
00:46:41,053 --> 00:46:44,990
WHETHER IT IS ALCOHOL, OPIOID 

1165
00:46:44,990 --> 00:46:45,591
USE, TOBACCO.

1166
00:46:45,591 --> 00:46:47,926
AND GENETICS HAS BEEN 

1167
00:46:47,926 --> 00:46:48,227
RECOGNIZED.

1168
00:46:48,227 --> 00:46:51,196
THAT WAS RECOGNIZED FIRST IN THE

1169
00:46:51,196 --> 00:46:52,131
ALCOHOL FIELD.

1170
00:46:52,131 --> 00:46:59,004
AND PERHAPS MOST OF THE 

1171
00:46:59,004 --> 00:47:01,140
HERITABILITY STUDIES WERE 

1172
00:47:01,140 --> 00:47:02,908
INVESTIGATING THE RISK OF 

1173
00:47:02,908 --> 00:47:04,276
ALCOHOLISM AND NOBODY WOULD 

1174
00:47:04,276 --> 00:47:07,012
QUESTION THAT.

1175
00:47:07,012 --> 00:47:10,849
MORE RECENT INVESTIGATORS START 

1176
00:47:10,849 --> 00:47:14,153
TO IDENTITY SIGNIFICANT 

1177
00:47:14,153 --> 00:47:16,221
HERITABILITY OF OTHER SUBSTANCE 

1178
00:47:16,221 --> 00:47:18,457
USE DISORDERS.

1179
00:47:18,457 --> 00:47:26,565
WITH THE MASSIVE DID THAT CAN BE

1180
00:47:26,565 --> 00:47:37,109
BROUGHT TOGETHER TO -- AND THIS 

1181
00:47:37,109 --> 00:47:38,911
IS PERHAPS THE LARGEST STUDY TO 

1182
00:47:38,911 --> 00:47:41,780
MY KNOWLEDGE THAT HAS BEEN 

1183
00:47:41,780 --> 00:47:43,916
PUBLISHED VIS-A-VIS THE SAMPLE 

1184
00:47:43,916 --> 00:47:44,883
SIZES.

1185
00:47:44,883 --> 00:47:47,219
MORE THAN 1 MILLION SUBJECTS.

1186
00:47:47,219 --> 00:47:50,389
IT IS IDENTIFYING UNDERLYING 

1187
00:47:50,389 --> 00:47:51,690
SUBSTANCE USE DISORDERS.

1188
00:47:51,690 --> 00:47:54,760
THE MAIN FINDING OF THESE 

1189
00:47:54,760 --> 00:47:58,463
STUDIES, LIKE OTHERS, THEY ARE 

1190
00:47:58,463 --> 00:48:01,667
POLYGENIC RESOURCE, NOT JUST ONE

1191
00:48:01,667 --> 00:48:02,768
GENE, MULTIPLE GENES.

1192
00:48:02,768 --> 00:48:04,469
THAT IS FINDING NUMBER ONE.

1193
00:48:04,469 --> 00:48:06,605
WE ALREADY KNEW FROM OTHER 

1194
00:48:06,605 --> 00:48:09,641
STUDIES THAT PRECEDED IT.

1195
00:48:09,641 --> 00:48:12,211
THE OTHER EXTREMELY IMPORTANT 

1196
00:48:12,211 --> 00:48:15,147
FINDING FROM THIS STUDY IS THE 

1197
00:48:15,147 --> 00:48:17,049
MAIN VULNERABILITY OF THE GENE'S

1198
00:48:17,049 --> 00:48:18,483
CONFER IS NOT TO SPECIFIC 

1199
00:48:18,483 --> 00:48:18,817
ADDICTIONS.

1200
00:48:18,817 --> 00:48:20,819
IT IS NOT LIKE THERE IS A 

1201
00:48:20,819 --> 00:48:22,654
VULNERABILITY FOR TOBACCO 

1202
00:48:22,654 --> 00:48:25,457
ADDICTION, THAT IS THE MAIN SIZE

1203
00:48:25,457 --> 00:48:28,060
OR CANNABIS OR OPIOID ADDICTION 

1204
00:48:28,060 --> 00:48:29,461
OR ALCOHOL.

1205
00:48:29,461 --> 00:48:32,130
IT IS INSTEAD A GENERAL 

1206
00:48:32,130 --> 00:48:33,599
VULNERABILITY FACTOR FOR 

1207
00:48:33,599 --> 00:48:34,266
ADDICTION.

1208
00:48:34,266 --> 00:48:37,803
AND THAT IS ULTIMATELY THE DATA 

1209
00:48:37,803 --> 00:48:41,907
BY ITSELF, BY FAR THAT HAS THE 

1210
00:48:41,907 --> 00:48:46,144
LARGER EFFECT SIZES FROM ANY OF 

1211
00:48:46,144 --> 00:48:48,213
THE OTHER SAMPLES OF SUBSTANCE 

1212
00:48:48,213 --> 00:48:49,481
USE DISORDERS.

1213
00:48:49,481 --> 00:48:51,116
IT IS INTERESTING BECAUSE WHEN 

1214
00:48:51,116 --> 00:48:54,753
YOU LOOK AT IT, THERE ARE 42 

1215
00:48:54,753 --> 00:48:59,758
GENES ON THAT POLYGENIC SCORE.

1216
00:48:59,758 --> 00:49:01,026
BUT FOUR WEIGHT THE MOST.

1217
00:49:01,026 --> 00:49:04,730
IT IS INTERESTING BECAUSE IT 

1218
00:49:04,730 --> 00:49:06,164
IDENTIFIED HAVING THE HIGHEST 

1219
00:49:06,164 --> 00:49:09,067
WEIGHT IN CONTRIBUTING TO OUR 

1220
00:49:09,067 --> 00:49:12,104
RACE FOR THIS GENETIC FACTOR.

1221
00:49:12,104 --> 00:49:14,773
THE F T O GENE THAT HAS ALSO 

1222
00:49:14,773 --> 00:49:17,643
BEEN LINKED FOR VULNERABILITY 

1223
00:49:17,643 --> 00:49:20,946
WITH OBESITY, THE DOPAMINE D2 

1224
00:49:20,946 --> 00:49:22,281
RECEPTOR, ASSOCIATED WITH 

1225
00:49:22,281 --> 00:49:25,183
VULNERABILITY FOR A WIDE VARIETY

1226
00:49:25,183 --> 00:49:29,821
OF ADDICTIONS AND THE 4B GENE 

1227
00:49:29,821 --> 00:49:32,190
HAS BEEN IDENTIFIED BY SOME AS A

1228
00:49:32,190 --> 00:49:32,891
POTENTIAL TARGET FOR THE 

1229
00:49:32,891 --> 00:49:36,094
TREATMENTS OF ADDICTION.

1230
00:49:36,094 --> 00:49:42,701
AND IT IS AN ENZYME INVOLVED IN 

1231
00:49:42,701 --> 00:49:47,239
THE DEGRADATION OF AN 

1232
00:49:47,239 --> 00:49:48,173
INTRACELLULAR MESSENGER.

1233
00:49:48,173 --> 00:49:50,275
IT STARTED BY THE EFFECTS OF 

1234
00:49:50,275 --> 00:49:50,475
DRUGS.

1235
00:49:50,475 --> 00:49:51,276
WE KNOW THAT.

1236
00:49:51,276 --> 00:49:52,611
WHAT IS INTERESTING BECAUSE 

1237
00:49:52,611 --> 00:49:54,947
AGAIN THAT IS WHY I STARTED MY 

1238
00:49:54,947 --> 00:49:57,349
TALK LIKE THAT, THESE GENES, 

1239
00:49:57,349 --> 00:50:01,286
THESE POLYGENIC SCORES NOT ONLY 

1240
00:50:01,286 --> 00:50:03,822
INCREASES THE RISK OF MULTIPLE 

1241
00:50:03,822 --> 00:50:05,991
SUBSTANCE USE DISORDERS BUT 

1242
00:50:05,991 --> 00:50:07,626
OTHER MENTAL PSYCHIATRIC 

1243
00:50:07,626 --> 00:50:10,929
DISORDERS, INCLUDING SUICIDAL 

1244
00:50:10,929 --> 00:50:13,532
BEHAVIOR, ANXIOUSLY, DEPRESSION 

1245
00:50:13,532 --> 00:50:15,667
AND EXTERNALIZING BEHAVIORS.

1246
00:50:15,667 --> 00:50:17,970
PROVIDING AN UNDERSTANDING ABOUT

1247
00:50:17,970 --> 00:50:20,205
WHY IS IT SO PREVALENT WE HAVE 

1248
00:50:20,205 --> 00:50:25,677
THESE CONDITIONS, WHY DO PEOPLE 

1249
00:50:25,677 --> 00:50:27,346
HAVE THEM AND THEY RUN IN 

1250
00:50:27,346 --> 00:50:27,612
FAMILIES?

1251
00:50:27,612 --> 00:50:29,748
IT IS A CONCEPT AND ULTIMATELY 

1252
00:50:29,748 --> 00:50:32,284
IT SHOULD BE HOW WE TRANSLATE 

1253
00:50:32,284 --> 00:50:34,486
THESE INTO INTERVENTIONS AND 

1254
00:50:34,486 --> 00:50:37,823
EVENTUALLY OBVIOUSLY DEVELOPMENT

1255
00:50:37,823 --> 00:50:39,257
OF PREVENTION AND TREATMENT.

1256
00:50:39,257 --> 00:50:40,792
THE OTHER EXTREMELY IMPORTANT 

1257
00:50:40,792 --> 00:50:42,728
COMPONENT FOR ALL OF THE 

1258
00:50:42,728 --> 00:50:44,730
SUBSTANCE USE DISORDERS AND 

1259
00:50:44,730 --> 00:50:47,065
BEHAVIORAL DISORDERS IS THAT 

1260
00:50:47,065 --> 00:50:48,166
ACTUALLY THE SOCIAL DETERMINANTS

1261
00:50:48,166 --> 00:50:49,401
OF HEALTH.

1262
00:50:49,401 --> 00:50:55,040
IN PARTICULARLY THE CHILDHOOD 

1263
00:50:55,040 --> 00:50:56,208
EXPERIENCES.

1264
00:50:56,208 --> 00:50:58,510
I'M SHOWING YOU A SLIDE THAT IS 

1265
00:50:58,510 --> 00:51:00,278
VERY OLD, BUT IT IS VERY 

1266
00:51:00,278 --> 00:51:00,545
ELOQUENT.

1267
00:51:00,545 --> 00:51:02,080
IT SPEAKS BY YOURSELF.

1268
00:51:02,080 --> 00:51:04,583
IT TELLS YOU WE ARE LOOKING AT 

1269
00:51:04,583 --> 00:51:05,917
GENETICS AND THEY ARE IMPORTANT 

1270
00:51:05,917 --> 00:51:08,186
AND THEY PROVIDE AND MAY 

1271
00:51:08,186 --> 00:51:10,722
INCREASE MY RISK OF THAT 

1272
00:51:10,722 --> 00:51:13,525
VULNERABILITY FACTOR.

1273
00:51:13,525 --> 00:51:16,061
ED A VERAS CHILDHOOD EXPERIENCES

1274
00:51:16,061 --> 00:51:18,730
INCREASE RISK FOR A SUBSTANCE 

1275
00:51:18,730 --> 00:51:25,537
USE DISORDER EIGHT FOLD.

1276
00:51:25,537 --> 00:51:27,672
WE HAVE KNOWLEDGE THAT CERTAIN 

1277
00:51:27,672 --> 00:51:28,774
EXPERIENCES, PARTICULARLY DURING

1278
00:51:28,774 --> 00:51:32,010
CHILDHOOD, CAN HAVE LONG LASTING

1279
00:51:32,010 --> 00:51:34,746
IMPACT IN THE WELL BEING, IN THE

1280
00:51:34,746 --> 00:51:36,882
MENTAL HEALTH WELL BEING, 

1281
00:51:36,882 --> 00:51:39,351
INCLUDING THE RISK OF SUBSTANCE 

1282
00:51:39,351 --> 00:51:40,952
USE DISORDER OF THAT CHILD AS 

1283
00:51:40,952 --> 00:51:42,320
THEY GROW INTO ADULTHOOD.

1284
00:51:42,320 --> 00:51:44,289
BY THE WAY, THESE ADVERSE 

1285
00:51:44,289 --> 00:51:46,058
CHILDHOOD EXPERIENCES CAN IMPACT

1286
00:51:46,058 --> 00:51:48,260
OTHER MEDICAL CONDITIONS.

1287
00:51:48,260 --> 00:51:51,129
BECAUSE OF THAT, BECAUSE OF ITS 

1288
00:51:51,129 --> 00:51:53,432
IMPORTANCE, WE KNOW GENETICS AND

1289
00:51:53,432 --> 00:51:54,833
WE KNOW THAT ENVIRONMENT IS 

1290
00:51:54,833 --> 00:51:56,501
IMPORTANT, BUT WHAT WE DON'T 

1291
00:51:56,501 --> 00:52:00,038
REALLY KNOW IS WHAT IS IT THESE 

1292
00:52:00,038 --> 00:52:01,840
POLYGENIC SCORE IS DOING TO OUR 

1293
00:52:01,840 --> 00:52:05,177
ABILITY TO REACT TO THE 

1294
00:52:05,177 --> 00:52:06,411
EXPERIENCES THAT APPEAR THROUGH 

1295
00:52:06,411 --> 00:52:07,012
YOUR CHILDHOOD?

1296
00:52:07,012 --> 00:52:08,480
THAT IS THE GAP OF KNOWLEDGE 

1297
00:52:08,480 --> 00:52:10,182
WHERE WE DON'T HAVE.

1298
00:52:10,182 --> 00:52:12,417
HOW DO WE LINK THAT BASIC 

1299
00:52:12,417 --> 00:52:14,753
UNDERSTANDING OF THE GENES, THE 

1300
00:52:14,753 --> 00:52:16,321
MULTIPLICITY OF GENES AND THAT 

1301
00:52:16,321 --> 00:52:19,091
DIFFERENT WEIGHTS THEY HAVE IN 

1302
00:52:19,091 --> 00:52:19,858
AN INDIVIDUAL.

1303
00:52:19,858 --> 00:52:25,063
ULTIMATELY IN THE WAY THEY ARE 

1304
00:52:25,063 --> 00:52:26,364
GOING TO DRIVE TO A CERTAIN 

1305
00:52:26,364 --> 00:52:30,235
EXTENT, INCREASE THE LIKELIHOOD 

1306
00:52:30,235 --> 00:52:31,670
THEY RESPOND IN CERTAIN WAYS TO 

1307
00:52:31,670 --> 00:52:32,771
THE ENVIRONMENT THEY ARE BROUGHT

1308
00:52:32,771 --> 00:52:33,638
UP WITH.

1309
00:52:33,638 --> 00:52:35,941
THAT IS HOW THE TWO GIGANTIC 

1310
00:52:35,941 --> 00:52:38,477
STUDIES THAT SOME OF THE MOST 

1311
00:52:38,477 --> 00:52:40,779
IMPORTANT ONES THAT WE ARE DOING

1312
00:52:40,779 --> 00:52:41,847
GOT BORN.

1313
00:52:41,847 --> 00:52:44,616
THE ADOLESCENT BRAIN COGNITIVE 

1314
00:52:44,616 --> 00:52:47,619
DEVELOPMENT, ABCD STUDY TO YOUR 

1315
00:52:47,619 --> 00:52:50,055
RIGHT, WHICH WAS BORN IN 

1316
00:52:50,055 --> 00:52:51,389
INTERACTIONS AND DISCUSSIONS 

1317
00:52:51,389 --> 00:52:53,291
BETWEEN GEORGE KOOB AND MYSELF 

1318
00:52:53,291 --> 00:52:55,293
WHEN WE WERE TASKED WITH CRAN 

1319
00:52:55,293 --> 00:52:56,761
WHAT COULD BE REALLY 

1320
00:52:56,761 --> 00:52:58,530
TRANSFORMATIVE THAT GIVES US THE

1321
00:52:58,530 --> 00:53:00,098
OPPORTUNITY BY BRINGING TOGETHER

1322
00:53:00,098 --> 00:53:02,334
THE INSTITUTES TOGETHER TO DO 

1323
00:53:02,334 --> 00:53:03,869
SOMETHING NO ONE ELSE HAS DONE.

1324
00:53:03,869 --> 00:53:06,838
THAT IS HOW THE ABCD WAS DONE, 

1325
00:53:06,838 --> 00:53:08,807
TO ACTUALLY IDENTIFY IN A LARGE 

1326
00:53:08,807 --> 00:53:10,876
COHORT RESPECTIVELY HOW THE 

1327
00:53:10,876 --> 00:53:13,278
BRAIN DEVELOPMENTS, HOW IT IS 

1328
00:53:13,278 --> 00:53:15,647
INFLUENCED BY GENETICS, HOW 

1329
00:53:15,647 --> 00:53:17,749
ENVIRONMENT AFFECTS IT.

1330
00:53:17,749 --> 00:53:19,284
IT WAS INITIATED IN 2016.

1331
00:53:19,284 --> 00:53:22,787
IT IS CLOSE TO 10 YEARS, WHICH 

1332
00:53:22,787 --> 00:53:24,322
WAS ITS ORIGINAL TIMELINE.

1333
00:53:24,322 --> 00:53:25,790
YOU WILL WITH BE HEARING SOME OF

1334
00:53:25,790 --> 00:53:29,427
THE DETAILS THIS AFTERNOON BY 

1335
00:53:29,427 --> 00:53:33,064
DR. GAYA DOWLING WHO HAS BEEN 

1336
00:53:33,064 --> 00:53:35,500
DIRECTING THIS EXTREMELY 

1337
00:53:35,500 --> 00:53:37,936
EXCITING STUDY.

1338
00:53:37,936 --> 00:53:40,105
THIS STUDY WAS BORN OUT OF CRAN 

1339
00:53:40,105 --> 00:53:42,707
IN CLOSE COLLABORATION WITH THE 

1340
00:53:42,707 --> 00:53:43,909
ALCOHOL INSTITUTE.

1341
00:53:43,909 --> 00:53:47,279
NCI, NIMH AND OTHER INSTITUTES.

1342
00:53:47,279 --> 00:53:49,247
WAS SO SUCCESSFUL THAT IT 

1343
00:53:49,247 --> 00:53:51,449
INSPIRED US TO SAY, OKAY, WE 

1344
00:53:51,449 --> 00:53:53,818
KNOW THAT THE ABCD WE STARTED 

1345
00:53:53,818 --> 00:53:55,687
SCREENING AND RECRUITING 

1346
00:53:55,687 --> 00:53:58,924
CHILDREN 9 TO 10 YEARS OF AGE IS

1347
00:53:58,924 --> 00:54:01,393
ALL MISSING A HUGE STAGE OF 

1348
00:54:01,393 --> 00:54:01,693
DEVELOPMENT.

1349
00:54:01,693 --> 00:54:04,529
WE DO KNOW THAT EARLY CHILDHOOD 

1350
00:54:04,529 --> 00:54:10,068
IS CRUCIAL IN IMPRINTING OUR 

1351
00:54:10,068 --> 00:54:11,369
BRAINS.

1352
00:54:11,369 --> 00:54:12,971
SO REALIZES THAT WE HAD LEARNED 

1353
00:54:12,971 --> 00:54:18,677
HOW TO DO SUCH A COMPLEX STUDY, 

1354
00:54:18,677 --> 00:54:20,845
WE LAUNCHED IN 2023, BASICALLY 

1355
00:54:20,845 --> 00:54:23,148
BEFORE THAT, 2021 WE LAUNCHED 

1356
00:54:23,148 --> 00:54:25,650
THE PILOT STUDIES AN EQUIVALENT 

1357
00:54:25,650 --> 00:54:27,719
STUDY THAT IS THE HEALTHY BRAIN 

1358
00:54:27,719 --> 00:54:30,055
AND CHILD DEVELOPMENT STUDY.

1359
00:54:30,055 --> 00:54:34,025
IT IS INITIATED IN INFANCY.

1360
00:54:34,025 --> 00:54:36,027
AND HAS BASICALLY -- IS RELYING 

1361
00:54:36,027 --> 00:54:38,663
ON RECRUITING PREGNANT WOMEN 

1362
00:54:38,663 --> 00:54:44,202
WITH THE PLAN OF ACTUALLY 

1363
00:54:44,202 --> 00:54:45,237
MONITORING THEIR CHILDREN FOR 10

1364
00:54:45,237 --> 00:54:46,438
YEARS.

1365
00:54:46,438 --> 00:54:49,574
IT AIMS TO ACTUALLY RECRUIT 

1366
00:54:49,574 --> 00:54:51,610
APPROXIMATELY 7,000 INFANTS.

1367
00:54:51,610 --> 00:54:54,112
AND WE -- YOU WILL BE HEARING 

1368
00:54:54,112 --> 00:55:00,185
DETAILS OF THESE STUDIES LATER 

1369
00:55:00,185 --> 00:55:01,853
TODAY BY CHRISTOPHER SARAMPOTE 

1370
00:55:01,853 --> 00:55:03,922
WHO IS THE DIRECTOR OF THIS 

1371
00:55:03,922 --> 00:55:04,522
PROGRAM.

1372
00:55:04,522 --> 00:55:06,858
SO IN THE MEANTIME, I DO WANT TO

1373
00:55:06,858 --> 00:55:08,760
HIGHLIGHT TWO EXAMPLES BECAUSE 

1374
00:55:08,760 --> 00:55:10,495
THEY ILLUSTRATE ACTUALLY SOME OF

1375
00:55:10,495 --> 00:55:16,935
THE ISSUES OF WHY THIS IS SO 

1376
00:55:16,935 --> 00:55:17,602
EXTREMELY IMPORTANT.

1377
00:55:17,602 --> 00:55:20,205
AND WHAT DOES IT GUIDE US IN 

1378
00:55:20,205 --> 00:55:21,206
TERMS OF INTERVENTIONS TO 

1379
00:55:21,206 --> 00:55:23,275
ADDRESS THE PROBLEM OF SUBSTANCE

1380
00:55:23,275 --> 00:55:24,576
USE DISORDERS OVERALL, WHICH AS 

1381
00:55:24,576 --> 00:55:26,411
I SAY AND YOU ARE GOING TO BE 

1382
00:55:26,411 --> 00:55:28,647
HEARING ME ALL ALONG, 

1383
00:55:28,647 --> 00:55:30,115
INTERVENTIONS I WOULD PUT 

1384
00:55:30,115 --> 00:55:31,950
FORWARD AS THE MOST CRUCIAL ONE 

1385
00:55:31,950 --> 00:55:35,086
OF HOW DO WE PREVENT THEM.

1386
00:55:35,086 --> 00:55:38,823
WE HAD SEEN, YES, 

1387
00:55:38,823 --> 00:55:41,159
EPIDEMIOLOGICAL STUDIES THAT 

1388
00:55:41,159 --> 00:55:43,762
ADVERSE ENVIRONMENTS ARE 

1389
00:55:43,762 --> 00:55:46,031
ASSOCIATED WITH WORSE OUTCOMES 

1390
00:55:46,031 --> 00:55:48,166
AND ESPECIALLY WITH SUBSTANCE 

1391
00:55:48,166 --> 00:55:49,000
USE DISORDERS.

1392
00:55:49,000 --> 00:55:50,702
THROUGH THE ABCD THEY HAVE DONE 

1393
00:55:50,702 --> 00:55:53,038
MANY, MANY STUDIES THAT HAVE 

1394
00:55:53,038 --> 00:55:55,373
SHOWN SEVERAL FACTORS THE SOCIAL

1395
00:55:55,373 --> 00:55:57,075
DETERMINANTS OF HEALTH THAT 

1396
00:55:57,075 --> 00:55:57,976
NEGATIVELY IMPACT THE 

1397
00:55:57,976 --> 00:55:59,277
DEVELOPMENT OF THE BRAIN OF 

1398
00:55:59,277 --> 00:56:01,513
THESE TEENAGERS.

1399
00:56:01,513 --> 00:56:04,049
IN PARTICULARLY, CHILDREN THAT 

1400
00:56:04,049 --> 00:56:06,117
COME FROM LOW-INCOME FAMILIES, 

1401
00:56:06,117 --> 00:56:08,186
FOR EXAMPLE, HAVE SIGNIFICANT 

1402
00:56:08,186 --> 00:56:08,853
CHANGES IN THEIR BRAIN 

1403
00:56:08,853 --> 00:56:14,426
DEVELOPMENT IN TERMS OF 

1404
00:56:14,426 --> 00:56:16,594
MORPHOLOGY AND CONNECTIVITY.

1405
00:56:16,594 --> 00:56:19,030
THESE CHANGES IN TURN ARE 

1406
00:56:19,030 --> 00:56:21,466
ASSOCIATED WITH WORSE COGNITIVE 

1407
00:56:21,466 --> 00:56:21,766
PERFORMANCE.

1408
00:56:21,766 --> 00:56:24,969
THIS HAS BEEN DOCUMENTED USING 

1409
00:56:24,969 --> 00:56:27,405
MULTIPLE MEASURES THAT ARE 

1410
00:56:27,405 --> 00:56:30,475
ACTUALLY INDICATORS OF IMPORTANT

1411
00:56:30,475 --> 00:56:34,212
FOR BRAIN DEVELOPMENT INCLUDING 

1412
00:56:34,212 --> 00:56:40,652
PREDOMINANTLY BRAIN MORPHOLOGY 

1413
00:56:40,652 --> 00:56:43,888
AND COGNITIVE CONNECTIVITY.

1414
00:56:43,888 --> 00:56:45,323
THEY LOOK AT WHITE MATTER 

1415
00:56:45,323 --> 00:56:45,790
TRACKS.

1416
00:56:45,790 --> 00:56:48,426
WE KNOW THAT THE BRAIN BASICALLY

1417
00:56:48,426 --> 00:56:51,029
HAS MORE NEURONS THAN IT IS 

1418
00:56:51,029 --> 00:56:53,164
ULTIMATELY GOING TO END UP WITH 

1419
00:56:53,164 --> 00:56:54,733
WHEN WE ARE BORN AND PART OF THE

1420
00:56:54,733 --> 00:56:57,702
PROCESS OF DEVELOPMENT IS TO 

1421
00:56:57,702 --> 00:56:59,170
MAXIMIZE THE NEURONS THAT ARE 

1422
00:56:59,170 --> 00:57:01,039
GOING TO BE ABLE TO RESPOND TO 

1423
00:57:01,039 --> 00:57:02,006
THE ENVIRONMENT WHICH THAT CHILD

1424
00:57:02,006 --> 00:57:04,376
IS EXPOSED TO.

1425
00:57:04,376 --> 00:57:07,479
AND TO CONNECT WITH THE NETWORKS

1426
00:57:07,479 --> 00:57:10,081
AND CLUSTER OF NEURONS NECESSARY

1427
00:57:10,081 --> 00:57:11,883
TO FORM THE ACTIVITIES THAT 

1428
00:57:11,883 --> 00:57:14,386
ULTIMATELY THE BRAIN PROCESSES.

1429
00:57:14,386 --> 00:57:17,389
AND THAT IS RELYING HEAVILY ON 

1430
00:57:17,389 --> 00:57:19,491
THE FORMATION OF WHITE MATTER 

1431
00:57:19,491 --> 00:57:20,859
CONNECTIONS.

1432
00:57:20,859 --> 00:57:25,397
SO THIS STUDY ACTUALLY DOES AN 

1433
00:57:25,397 --> 00:57:26,831
ELEGANT ANALYSIS OF THE STRENGTH

1434
00:57:26,831 --> 00:57:29,701
OF THOSE WHITE MATTER TRACKS.

1435
00:57:29,701 --> 00:57:37,542
YOU SEE WHITE MATTER FUNCT

1436
00:57:37,542 --> 00:57:39,778
FUNCTIONAL -- AND IT SHOWS THE 

1437
00:57:39,778 --> 00:57:41,713
HOUSEHOLD NICK BRACKET FROM 

1438
00:57:41,713 --> 00:57:43,114
WEALTHIER PARENTS TO THE RIGHT 

1439
00:57:43,114 --> 00:57:45,116
AND TO THE LEFT MORE 

1440
00:57:45,116 --> 00:57:47,352
ECONOMICALLY DEPRIVED FAMILIES.

1441
00:57:47,352 --> 00:57:48,586
YOU CAN CLEAR SEE THE 

1442
00:57:48,586 --> 00:57:51,389
CONNECTIONS ARE MUCH STRONGER IN

1443
00:57:51,389 --> 00:57:52,390
CHILDREN OF FAMILIES THAT ARE 

1444
00:57:52,390 --> 00:57:54,526
WELL TO DO.

1445
00:57:54,526 --> 00:57:56,661
WHICH IN A WAY IS LIKELY TO 

1446
00:57:56,661 --> 00:57:58,329
REFLECT THE FACT THAT A LOT OF 

1447
00:57:58,329 --> 00:58:00,198
PEOPLE HAVE WRITTEN ABOUT IT, 

1448
00:58:00,198 --> 00:58:02,834
WHEN PARENTS DON'T HAVE TO HAVE 

1449
00:58:02,834 --> 00:58:05,503
TO OR THREE JOBS IN ORDER TO 

1450
00:58:05,503 --> 00:58:07,105
MAINTAIN, TO PROVIDE FOOD AND 

1451
00:58:07,105 --> 00:58:09,340
HOUSING AND ARE NOT CONSTANTLY 

1452
00:58:09,340 --> 00:58:11,776
STRESSED, THEY CAN PAY MUCH MORE

1453
00:58:11,776 --> 00:58:13,711
ATTENTION AND CHALLENGE THOSE 

1454
00:58:13,711 --> 00:58:13,978
CHILDREN.

1455
00:58:13,978 --> 00:58:18,383
AND THAT IS NECESSARY FOR THE 

1456
00:58:18,383 --> 00:58:19,284
BRAIN TO DEVELOPMENT.

1457
00:58:19,284 --> 00:58:24,422
TO THE RIGHT WHAT YOU SEE IS THE

1458
00:58:24,422 --> 00:58:25,990
IT AFFECTS THE STRENGTH OF THE 

1459
00:58:25,990 --> 00:58:26,858
CONNECTION AND IN TURN THAT IS 

1460
00:58:26,858 --> 00:58:28,593
ONE OF THE FACTORS THAT DRIVES 

1461
00:58:28,593 --> 00:58:30,161
THE DIFFERENCES IN COGNITIONS 

1462
00:58:30,161 --> 00:58:32,697
YOU SEE IN CHILDREN OF DIFFERENT

1463
00:58:32,697 --> 00:58:33,064
HOUSEHOLDS.

1464
00:58:33,064 --> 00:58:36,201
SUCH THAT CHILDREN THAT COME 

1465
00:58:36,201 --> 00:58:38,603
DOCTOR BETTER TO DO ECONOMICALLY

1466
00:58:38,603 --> 00:58:42,874
FAMILIES DO BETTER IN COGNITIVE 

1467
00:58:42,874 --> 00:58:45,176
TASKS THAN THOSE THAT COME FROM 

1468
00:58:45,176 --> 00:58:45,977
LOWER-NUMBER FAMILIES.

1469
00:58:45,977 --> 00:58:48,980
AGAIN, NOT SURPRISING THE PLAIN 

1470
00:58:48,980 --> 00:58:52,183
IS A NEUROPLASTIC SYSTEM AND 

1471
00:58:52,183 --> 00:58:53,551
RESPONDS TO STIMULATION.

1472
00:58:53,551 --> 00:58:54,819
YOU NEED THE STIMULATION IN 

1473
00:58:54,819 --> 00:58:56,955
ORDER FOR THE CONNECTIONS TO 

1474
00:58:56,955 --> 00:58:57,155
FORM.

1475
00:58:57,155 --> 00:58:58,723
IF YOU DON'T GIVE THEM PROPERLY,

1476
00:58:58,723 --> 00:59:01,426
YOU ARE PUTTING THAT CHILD AT A 

1477
00:59:01,426 --> 00:59:01,759
DISADVANTAGE.

1478
00:59:01,759 --> 00:59:03,328
THE OTHER ONE I WANT TO 

1479
00:59:03,328 --> 00:59:05,396
EMPHASIZE HERE IS BECAUSE IT IS 

1480
00:59:05,396 --> 00:59:07,365
NOT NECESSARILY WHAT PEOPLE WILL

1481
00:59:07,365 --> 00:59:10,435
HAVE EXPECTED AS A FINDING, IS A

1482
00:59:10,435 --> 00:59:12,070
PAPER THAT GOT PUBLISHED LAST 

1483
00:59:12,070 --> 00:59:12,270
YEAR.

1484
00:59:12,270 --> 00:59:15,640
AND IT WAS LOOKING AT NOW THAT 

1485
00:59:15,640 --> 00:59:18,676
THE ABCD CHILDREN ARE IN LATER 

1486
00:59:18,676 --> 00:59:20,278
TEENAGE YEARS, THEY ARE STARTING

1487
00:59:20,278 --> 00:59:21,479
TO TAKE DRUGS SO THAT 

1488
00:59:21,479 --> 00:59:22,714
RESEARCHERS ARE LOOKING AT THOSE

1489
00:59:22,714 --> 00:59:26,551
THAT ARE TAKING NOW ON THE ABCD 

1490
00:59:26,551 --> 00:59:29,354
CHILDREN THAT MAY BE USING 

1491
00:59:29,354 --> 00:59:30,755
ALCOHOL, NICOTINE OR CANNABIS 

1492
00:59:30,755 --> 00:59:33,525
AND GOING BACKWARD AND SAYING 

1493
00:59:33,525 --> 00:59:34,692
ARE THERE CERTAIN DIRECTORIES 

1494
00:59:34,692 --> 00:59:37,428
THAT COULD HAVE LEAD US TO 

1495
00:59:37,428 --> 00:59:40,198
PREDICT THEY WERE ALL GOING TO 

1496
00:59:40,198 --> 00:59:42,700
DEVELOP -- START TO USE 

1497
00:59:42,700 --> 00:59:43,001
SUBSTANCES?

1498
00:59:43,001 --> 00:59:43,668
VERY IMPORTANT QUESTION BECAUSE 

1499
00:59:43,668 --> 00:59:45,703
IT RELATES TO THE NOTION, TWO 

1500
00:59:45,703 --> 00:59:46,004
THINGS.

1501
00:59:46,004 --> 00:59:48,840
ONE OF THEM, ARE THERE CERTAIN 

1502
00:59:48,840 --> 00:59:50,475
FACTORS IN YOUR BRAIN THAT MAKE 

1503
00:59:50,475 --> 00:59:53,311
YOU VULNERABLE TO ACTUALLY MORE 

1504
00:59:53,311 --> 00:59:55,246
LIKELY TO DO SUBSTANCES?

1505
00:59:55,246 --> 00:59:58,416
AND THE OTHER ONE IS WE ARE VERY

1506
00:59:58,416 --> 00:59:59,751
INTERESTED IN UNDERSTANDING HOW 

1507
00:59:59,751 --> 01:00:02,720
DRUGS USED DURING ADOLESCENCE 

1508
01:00:02,720 --> 01:00:04,522
COULD NEGATIVELY IMPACT YOUR 

1509
01:00:04,522 --> 01:00:04,722
BRAIN.

1510
01:00:04,722 --> 01:00:06,190
SO IT IS RELATIVE TO THAT.

1511
01:00:06,190 --> 01:00:08,826
WHAT IS FASCINATING FOR MY BRAIN

1512
01:00:08,826 --> 01:00:10,528
IS WHAT YOU SEE ON THE LEFT.

1513
01:00:10,528 --> 01:00:16,200
IFT SORT OF SAYS REGIONAL 

1514
01:00:16,200 --> 01:00:17,702
CORTICAL VOLUMES AND THICKNESS 

1515
01:00:17,702 --> 01:00:19,804
ASSOCIATIONS WITH EARLY 

1516
01:00:19,804 --> 01:00:22,240
SUBSTANCE USE OR ALCOHOL IN A OR

1517
01:00:22,240 --> 01:00:23,808
B, THEY ARE VERY, VERY SIMILAR.

1518
01:00:23,808 --> 01:00:26,210
THE COLORS REPRESENT AREAS WHERE

1519
01:00:26,210 --> 01:00:29,681
YOU HAVE LESS VOLUME IN PURPLE 

1520
01:00:29,681 --> 01:00:32,150
AND MORE VOLUME IN RED.

1521
01:00:32,150 --> 01:00:34,652
LESS COURT KOL THICKNESS IN 

1522
01:00:34,652 --> 01:00:35,820
PURPLE AND MORE COURT KOL 

1523
01:00:35,820 --> 01:00:39,757
THICKNESS IN RED.

1524
01:00:39,757 --> 01:00:46,764
IF YOU CORTICAL -- LESS CORTICAL

1525
01:00:46,764 --> 01:00:52,437
THICKNESS IN PURPOSED AND MORE 

1526
01:00:52,437 --> 01:00:53,738
CORTICAL THICKNESS IN RED.

1527
01:00:53,738 --> 01:00:55,840
THERE ARE OTHER AREAS OF THE 

1528
01:00:55,840 --> 01:00:58,610
BRAIN THAT SHOW MORE VOLUMES AND

1529
01:00:58,610 --> 01:01:01,112
THINNER CORTICAL THICKNESS.

1530
01:01:01,112 --> 01:01:04,182
INTERESTINGLY, LET'S LOOK AT 

1531
01:01:04,182 --> 01:01:05,016
CORTICAL THICKNESS.

1532
01:01:05,016 --> 01:01:07,485
LESS CORTICAL THICKNESS ON THOSE

1533
01:01:07,485 --> 01:01:10,989
GOING ON TO TAKE DRUGS IN MEDIAL

1534
01:01:10,989 --> 01:01:14,959
AREAS OF THE BRAIN, THE FRONTAL 

1535
01:01:14,959 --> 01:01:20,565
CORTEX AND THE WHOLE MEDIA 

1536
01:01:20,565 --> 01:01:20,798
BROGMAN.

1537
01:01:20,798 --> 01:01:27,171
THESE ARE ASSOCIATED WITH 

1538
01:01:27,171 --> 01:01:27,705
CORTICES.

1539
01:01:27,705 --> 01:01:29,540
THERE IS THE CORTEX HERE.

1540
01:01:29,540 --> 01:01:35,613
THAT AREA OF THE BRAIN IS A 

1541
01:01:35,613 --> 01:01:39,150
PRIMARY MOTOR REGION.

1542
01:01:39,150 --> 01:01:45,089
THIS WAS INTRIGUING BECAUSE 

1543
01:01:45,089 --> 01:01:50,194
STUDIES ON LOW-INCOME SHOWED A 

1544
01:01:50,194 --> 01:01:52,230
SIMILAR PATTERN.

1545
01:01:52,230 --> 01:01:55,333
MORE CORTICAL THICKNESS IN SUB 

1546
01:01:55,333 --> 01:01:57,368
MATTER AND SIMILARLY WITH THE 

1547
01:01:57,368 --> 01:02:00,004
VOLUMES INDICATING THAT IN FACT 

1548
01:02:00,004 --> 01:02:02,273
PERHAPS AND AGAIN WHEN WE ARE 

1549
01:02:02,273 --> 01:02:04,208
DISCUSSING THE NOTION OF HOW DO 

1550
01:02:04,208 --> 01:02:06,244
ADVERSE ENVIRONMENTS ULTIMATELY 

1551
01:02:06,244 --> 01:02:10,982
MAKE YOU MORE VULNERABLE.

1552
01:02:10,982 --> 01:02:12,417
THIS MAY CONTRIBUTE.

1553
01:02:12,417 --> 01:02:13,084
WHY?

1554
01:02:13,084 --> 01:02:14,819
BECAUSE YOU REQUIRE YOUR 

1555
01:02:14,819 --> 01:02:16,621
PREFRONTAL CORTEX CERTAINLY TO 

1556
01:02:16,621 --> 01:02:20,158
ACTUALLY MAKE DECISIONS AND 

1557
01:02:20,158 --> 01:02:23,294
SELF-REGULATE YOURSELF.

1558
01:02:23,294 --> 01:02:25,296
ON THE OTHER HAND, THESE PRIMARY

1559
01:02:25,296 --> 01:02:27,265
AREAS OF THE CORTEX ALLOW US TO 

1560
01:02:27,265 --> 01:02:29,267
BE VERY, VERY RESPONSIVE, BUT IN

1561
01:02:29,267 --> 01:02:31,636
A MUCH MORE AUTOMATIC FASHION.

1562
01:02:31,636 --> 01:02:35,540
I THINK AS WE GATHER THIS 

1563
01:02:35,540 --> 01:02:36,841
INFORMATION, THEN THE QUESTION 

1564
01:02:36,841 --> 01:02:38,943
IS ARE THERE THINGS WE CAN DO IF

1565
01:02:38,943 --> 01:02:41,079
YOU HAVE SOMEONE ALREADY TAKING 

1566
01:02:41,079 --> 01:02:44,582
DRUGS THAT CAN HELP BUFFER THESE

1567
01:02:44,582 --> 01:02:44,982
CHANGES?

1568
01:02:44,982 --> 01:02:46,584
AND MY ANSWER IS I BET YOU THEY 

1569
01:02:46,584 --> 01:02:47,418
ARE.

1570
01:02:47,418 --> 01:02:47,585
WHY?

1571
01:02:47,585 --> 01:02:49,020
BECAUSE THE BRAIN IS VERY 

1572
01:02:49,020 --> 01:02:49,287
PLASTIC.

1573
01:02:49,287 --> 01:02:53,858
IF WE CAN PROVIDE THE TYPE OF 

1574
01:02:53,858 --> 01:02:55,359
STIMULATION THAT WILL ENGAGE 

1575
01:02:55,359 --> 01:02:57,428
THESE CORTICAL AREAS, I SUSPECT 

1576
01:02:57,428 --> 01:02:59,697
WE ARE GOING TO START TO SEE 

1577
01:02:59,697 --> 01:03:03,067
THEM BASICALLY RECOVERING TO 

1578
01:03:03,067 --> 01:03:04,736
PATTERNS IN OTHER CHILDREN THAT 

1579
01:03:04,736 --> 01:03:11,576
ARE PERFORMING WELL AT SCHOOL.

1580
01:03:11,576 --> 01:03:13,878
SO TODAY YOU ARE GOING TO SEE 

1581
01:03:13,878 --> 01:03:17,648
THE PRESENTATION FOR THE HBCD.

1582
01:03:17,648 --> 01:03:19,150
I'M SHOWING YOU NOT TO DWELL ON 

1583
01:03:19,150 --> 01:03:21,018
ANYTHING EXCEPT FOR THE FACT TO 

1584
01:03:21,018 --> 01:03:23,755
DOCUMENT AN ASPECT WE NEED TO 

1585
01:03:23,755 --> 01:03:25,289
ACTUALLY BE MUCH MORE PROACTIVE 

1586
01:03:25,289 --> 01:03:29,460
ON BREAKING IS THIS JUST TELLS 

1587
01:03:29,460 --> 01:03:31,662
US THE DRUGS THAT PREGNANT WOMEN

1588
01:03:31,662 --> 01:03:32,463
ARE TAKING.

1589
01:03:32,463 --> 01:03:34,465
IT WAS MENTIONED MORE WOMEN THAT

1590
01:03:34,465 --> 01:03:36,400
ARE PREGNANT ARE TAKING HIGHER 

1591
01:03:36,400 --> 01:03:37,101
DOSES OF ALCOHOL.

1592
01:03:37,101 --> 01:03:41,272
BUT WHAT IS CLEAR IS THAT 

1593
01:03:41,272 --> 01:03:42,774
BASICALLY THE MAJORITY OF THE 

1594
01:03:42,774 --> 01:03:46,077
GROUPS THAT WE HAVE HAVE MORE 

1595
01:03:46,077 --> 01:03:47,979
THAN ONE SUBSTANCE.

1596
01:03:47,979 --> 01:03:50,381
YET OUR WORK HAS BEEN STUDYING 

1597
01:03:50,381 --> 01:03:52,183
ALCOHOL BY ITSELF, TOBACCO BY 

1598
01:03:52,183 --> 01:03:53,985
ITSELF, MARIJUANA BY ITSELF.

1599
01:03:53,985 --> 01:03:56,587
AND THERE IS LIKELY TO BE 

1600
01:03:56,587 --> 01:03:58,890
IMPORTANT INTERACTIONS BETWEEN 

1601
01:03:58,890 --> 01:04:04,095
HOW THESE TWO PHARMACOLOGICAL 

1602
01:04:04,095 --> 01:04:05,763
AGENTS INFLUENCE THE DEVELOPMENT

1603
01:04:05,763 --> 01:04:06,531
OF THE CHILDREN.

1604
01:04:06,531 --> 01:04:08,633
I'M USING THIS TO ILLUSTRATE 

1605
01:04:08,633 --> 01:04:08,933
THAT.

1606
01:04:08,933 --> 01:04:10,501
THEN FOR THE LAST PART OF MY 

1607
01:04:10,501 --> 01:04:12,470
TALK I JUST WANT TO GIVE YOU -- 

1608
01:04:12,470 --> 01:04:14,105
I GAVE YOU THIS YID, BUT THOSE 

1609
01:04:14,105 --> 01:04:19,510
THAT WERE NOT IN COUNCIL, WHERE 

1610
01:04:19,510 --> 01:04:22,246
WE ARE WITH THE OVERDOSE CRISIS.

1611
01:04:22,246 --> 01:04:24,081
VERY EXCITING NEWS.

1612
01:04:24,081 --> 01:04:26,184
WE HAVE BEEN SEEING SIGNIFICANT 

1613
01:04:26,184 --> 01:04:27,952
DECLINES IN MORTALITY IN THE 

1614
01:04:27,952 --> 01:04:29,520
PAST YEAR AND THE LARGEST 

1615
01:04:29,520 --> 01:04:31,122
CHANGES WERE OBSERVED IN THE 

1616
01:04:31,122 --> 01:04:33,257
LAST NUMBERS RECEIVED BY THE CDC

1617
01:04:33,257 --> 01:04:35,359
THAT CORRESPOND TO NOVEMBER 

1618
01:04:35,359 --> 01:04:35,693
2024.

1619
01:04:35,693 --> 01:04:39,764
WHERE WE ACTUALLY WHEN COMPARED 

1620
01:04:39,764 --> 01:04:42,400
TO NOVEMBER 23 WERE SEEING A 2% 

1621
01:04:42,400 --> 01:04:44,402
REDUCTION IN OVERDOSE MORTALITY,

1622
01:04:44,402 --> 01:04:47,438
WHICH IS VERY, VERY, VERY, VERY 

1623
01:04:47,438 --> 01:04:47,705
EXCITING.

1624
01:04:47,705 --> 01:04:49,607
THERE ARE STILL MANY, MANY 

1625
01:04:49,607 --> 01:04:51,008
CHALLENGES AND ONE OF THE MOST 

1626
01:04:51,008 --> 01:04:53,110
IMPORTANT ONES IS WHAT YOU ALSO 

1627
01:04:53,110 --> 01:04:55,112
THIS DATA IS SHOWING THAT THERE 

1628
01:04:55,112 --> 01:04:57,682
ARE MULTIPLE DRUGS THAT ARE 

1629
01:04:57,682 --> 01:04:59,817
CONTRIBUTED TO THE OVERDOSE 

1630
01:04:59,817 --> 01:05:00,117
MORTALITY.

1631
01:05:00,117 --> 01:05:03,287
WE FOCUS ON OPIOIDS BECAUSE 70% 

1632
01:05:03,287 --> 01:05:05,723
OF DEATHS CONTAIN OPIOIDS.

1633
01:05:05,723 --> 01:05:07,992
BUT WE DON'T REALIZE THAT MOST 

1634
01:05:07,992 --> 01:05:09,560
OF THOSE DEATHS ALSO CONTAIN 

1635
01:05:09,560 --> 01:05:10,428
OTHER DRUGS.

1636
01:05:10,428 --> 01:05:13,631
AND ALSO WE ARE NOT REALLY EVEN 

1637
01:05:13,631 --> 01:05:16,133
PROPERLY MONITORING FOR THE 

1638
01:05:16,133 --> 01:05:18,135
CO-PRESENCE OF ALCOHOL AND 

1639
01:05:18,135 --> 01:05:21,739
OPIOIDS WHICH CAN BE VERY, VERY 

1640
01:05:21,739 --> 01:05:23,107
MALIGNANT AND NOT GOING TO BE 

1641
01:05:23,107 --> 01:05:25,977
RESPONDING TO NALOXAN.

1642
01:05:25,977 --> 01:05:28,446
WE ARE NOT REACTING TO THE FACT 

1643
01:05:28,446 --> 01:05:31,182
THAT WHEN PEOPLE HAVE NOT JUST 

1644
01:05:31,182 --> 01:05:34,719
ONE SUBSTANCE USE DISORDER, 

1645
01:05:34,719 --> 01:05:40,191
ALCOHOL USE DISORDER, OPIOID USE

1646
01:05:40,191 --> 01:05:40,458
DISORDER.

1647
01:05:40,458 --> 01:05:42,560
THEY ARE TREATING WITH ALCOHOL 

1648
01:05:42,560 --> 01:05:44,762
DISORDER THAT IS VERY, VERY 

1649
01:05:44,762 --> 01:05:47,365
PREVALENT THEY ARE LIKELY TO GO 

1650
01:05:47,365 --> 01:05:50,067
BACK TO DRINKING EVEN ON 

1651
01:05:50,067 --> 01:05:54,372
MEDICATIONS TO OPIOID USE 

1652
01:05:54,372 --> 01:05:55,806
DISORDER AND THOSE INDIVIDUALS 

1653
01:05:55,806 --> 01:05:59,143
ARE HIGHER RISK FROM OVERDOSES.

1654
01:05:59,143 --> 01:06:00,278
SO WE'VE BEEN BASICALLY FOCUSING

1655
01:06:00,278 --> 01:06:05,149
AND SAYING WE NEED TO ALSO 

1656
01:06:05,149 --> 01:06:06,784
ENCOURAGE RESEARCHERS TO WORK IN

1657
01:06:06,784 --> 01:06:08,653
POLYSUBSTANCE USE DISORDERS.

1658
01:06:08,653 --> 01:06:11,155
I'M HIGHLIGHTING ONE TODAY ONLY.

1659
01:06:11,155 --> 01:06:12,723
I DID THAT YESTERDAY.

1660
01:06:12,723 --> 01:06:14,292
I'M DOING IT DIFFERENTLY TODAY.

1661
01:06:14,292 --> 01:06:22,633
WE ARE EXTREMELY EXCITED FOR THE

1662
01:06:22,633 --> 01:06:28,005
PEPTIDE MEDICATIONS FLP1R 

1663
01:06:28,005 --> 01:06:29,340
MEDICATIONINGS FOR ADDICTION 

1664
01:06:29,340 --> 01:06:29,607
TREATMENT.

1665
01:06:29,607 --> 01:06:31,542
IT TRANSFORMS THE WAY WE CAN 

1666
01:06:31,542 --> 01:06:33,044
HANDLE THESE CONDITIONS AND MORE

1667
01:06:33,044 --> 01:06:34,812
AND MORE PATIENTS ARE BEING 

1668
01:06:34,812 --> 01:06:36,213
TREATED WITH THESE MEDICATIONS 

1669
01:06:36,213 --> 01:06:37,448
AND AS A RESULT OF THAT, PEOPLE 

1670
01:06:37,448 --> 01:06:41,018
ARE STARTING TO REALIZE THAT IT 

1671
01:06:41,018 --> 01:06:42,787
NOT ONLY DECREASES THEIR CRAVING

1672
01:06:42,787 --> 01:06:45,056
FOR FOOD, BUT EVIDENTLY IT SEEMS

1673
01:06:45,056 --> 01:06:48,192
TO BE THEIR CRAVING AND DESIRE 

1674
01:06:48,192 --> 01:06:55,633
FOR DRUGS, BECOMIING SATIATED.

1675
01:06:55,633 --> 01:06:58,436
THE CLINICAL DATA NOTED THIS IS 

1676
01:06:58,436 --> 01:07:04,108
2015 SHOWING THAT, I MEAN NOT 

1677
01:07:04,108 --> 01:07:07,044
SURPRISING, THAT THE GLP1 

1678
01:07:07,044 --> 01:07:10,681
PEPTIDE RECEPTORS ARE IN THE 

1679
01:07:10,681 --> 01:07:12,249
DOPAMINE NUCLEI.

1680
01:07:12,249 --> 01:07:15,753
THERE IS DATA TO SHOW SOME 

1681
01:07:15,753 --> 01:07:17,221
DOPAMINE CELLS EXPRESS 

1682
01:07:17,221 --> 01:07:17,488
RECEPTORS.

1683
01:07:17,488 --> 01:07:20,491
SOME SAY THEY ARE IN THE GABBA 

1684
01:07:20,491 --> 01:07:20,825
CELLS.

1685
01:07:20,825 --> 01:07:26,130
BE IT AS IT MAY, THE V T A IS 

1686
01:07:26,130 --> 01:07:31,068
REGULATED BY -- LIKE PEPTIDE 

1687
01:07:31,068 --> 01:07:31,335
RELEASED.

1688
01:07:31,335 --> 01:07:35,773
AND THAT IN TURNS MODELS THE 

1689
01:07:35,773 --> 01:07:36,073
SIGNALLING.

1690
01:07:36,073 --> 01:07:38,309
THIS HAS BEEN SHOWN TO BE A 

1691
01:07:38,309 --> 01:07:41,746
MECHANISM BY WHICH THESE 

1692
01:07:41,746 --> 01:07:45,282
MEDICATIONS LIKE SEMI GLUTIDE 

1693
01:07:45,282 --> 01:07:47,718
REDUCE OVEREATING, HIGH FAT DIET

1694
01:07:47,718 --> 01:07:50,821
IS REDUCED BY THE USE OF THESE 

1695
01:07:50,821 --> 01:07:54,325
MEDICATIONS WHERE STANDARD DIETS

1696
01:07:54,325 --> 01:07:54,925
DO NOT.

1697
01:07:54,925 --> 01:07:57,628
AND THEY DO ACTUALLY REDUCE THE 

1698
01:07:57,628 --> 01:08:00,398
AMOUNT OF DOPAMINE RELEASED BY A

1699
01:08:00,398 --> 01:08:01,032
HIGH-FAT DIET.

1700
01:08:01,032 --> 01:08:03,034
THEY REDUCE THE AMOUNT OF 

1701
01:08:03,034 --> 01:08:05,569
DOPAMINE FROM COCAINE, ALCOHOL, 

1702
01:08:05,569 --> 01:08:06,003
FROM NICOTINE.

1703
01:08:06,003 --> 01:08:10,941
THIS IS JUST A VERY RECENT STUDY

1704
01:08:10,941 --> 01:08:14,345
PUBLISHING HOW EXENDIN THESE 

1705
01:08:14,345 --> 01:08:18,249
MEDICATIONS REDUCES COCAINE 

1706
01:08:18,249 --> 01:08:19,750
ADMINISTRATION AND SIGNIFICANTLY

1707
01:08:19,750 --> 01:08:23,554
REDUCES DOPAMINE INCREASING WITH

1708
01:08:23,554 --> 01:08:24,188
COCAINE.

1709
01:08:24,188 --> 01:08:26,991
MULTIPLE REPORTS FROM JUST 

1710
01:08:26,991 --> 01:08:29,126
FACES, FROM SMALL CLINICAL 

1711
01:08:29,126 --> 01:08:31,128
TRIALS, TWO RANDOMIZED CLINICAL 

1712
01:08:31,128 --> 01:08:33,097
TRIALS HAVE BEEN PUBLISHED FOR 

1713
01:08:33,097 --> 01:08:35,132
ALCOHOL, ONE WITH POSITIVE 

1714
01:08:35,132 --> 01:08:37,635
RESULTS AND ONE WITH I USED THE 

1715
01:08:37,635 --> 01:08:39,670
SECOND GENERATION DOCUMENTING 

1716
01:08:39,670 --> 01:08:41,372
DECREASES IN HEAVY DRINKING 

1717
01:08:41,372 --> 01:08:44,442
DAYS, BUT MANY STUDIES DONE 

1718
01:08:44,442 --> 01:08:46,410
BASED ON ELECTRONIC RESPECTIVE 

1719
01:08:46,410 --> 01:08:48,379
ANALYSIS SHOWING SIGNIFICANTLY 

1720
01:08:48,379 --> 01:08:53,951
BETTER OUTCOMES FOR ACTUALLY 

1721
01:08:53,951 --> 01:08:55,619
INDICATORS OF ALCOHOL 

1722
01:08:55,619 --> 01:08:59,623
CONSUMPTION, INDICATORS OF 

1723
01:08:59,623 --> 01:09:01,592
CRAVING IN OPIOID USE DISORDER 

1724
01:09:01,592 --> 01:09:04,995
AND INDICATORS OF TOBACCO AND 

1725
01:09:04,995 --> 01:09:09,333
USE OF NICOTINE AND REDUCING 

1726
01:09:09,333 --> 01:09:12,136
CANNABIS FOR PEOPLE WITH AN 

1727
01:09:12,136 --> 01:09:15,206
OPIOID USE DISORDER.

1728
01:09:15,206 --> 01:09:16,574
THE TEAM OF RESEARCHERS ALL OVER

1729
01:09:16,574 --> 01:09:19,243
THE WORLD CAME UP HIGHLIGHTING 

1730
01:09:19,243 --> 01:09:20,644
THAT THESE EXTREMELY PROMISING, 

1731
01:09:20,644 --> 01:09:23,414
BUT REQUIRES THAT WE ALL 

1732
01:09:23,414 --> 01:09:26,784
ACTUALLY DO THE WORK THAT IS 

1733
01:09:26,784 --> 01:09:28,052
NECESSARY TO DOCUMENT WHETHER --

1734
01:09:28,052 --> 01:09:30,354
WHAT IS THE EVIDENCE FOR 

1735
01:09:30,354 --> 01:09:31,655
EFFECTIVENESS OF THESE 

1736
01:09:31,655 --> 01:09:33,557
MEDICATIONS SO THEN THEY CAN BE 

1737
01:09:33,557 --> 01:09:36,227
PROVIDED TO PATIENTS IF THEY ARE

1738
01:09:36,227 --> 01:09:38,829
POSITIVE.

1739
01:09:38,829 --> 01:09:41,632
AND THE LAST POINT THAT I WANT 

1740
01:09:41,632 --> 01:09:43,300
TO MAKE IS OVERALL SORT OF 

1741
01:09:43,300 --> 01:09:45,236
SPEAKING ABOUT HOW WE NEED TO 

1742
01:09:45,236 --> 01:09:47,304
ADVANCE RESEARCH THAT ACTUALLY 

1743
01:09:47,304 --> 01:09:49,273
LEADS WITH THE CO-OCCURRENCE OF 

1744
01:09:49,273 --> 01:09:52,209
THESE SUBSTANCES BECAUSE THAT IS

1745
01:09:52,209 --> 01:09:54,678
WHAT BIOLOGY IS TELLING US IS 

1746
01:09:54,678 --> 01:09:56,013
HAPPENING BUT ALSO THAT LEADS TO

1747
01:09:56,013 --> 01:09:57,515
THE BEST CLINICAL OUTCOMES.

1748
01:09:57,515 --> 01:10:00,417
IT IS ALSO TELLING US, AND THIS 

1749
01:10:00,417 --> 01:10:02,052
IS SOMETHING THAT GEORGE HAS 

1750
01:10:02,052 --> 01:10:03,487
SPOKEN EXTENSIVELY ON.

1751
01:10:03,487 --> 01:10:05,256
WE HAVE SPOKEN TOGETHER.

1752
01:10:05,256 --> 01:10:06,957
WE HAVE WRITTEN ABOUT IT, IS 

1753
01:10:06,957 --> 01:10:09,994
THAT THE PROCESS OF ADDICTION IS

1754
01:10:09,994 --> 01:10:14,131
A CYCLE THAT ACTUALLY, LEADS 

1755
01:10:14,131 --> 01:10:15,032
PEOPLE INTO DIFFERENT STAGES 

1756
01:10:15,032 --> 01:10:17,902
FROM THE USE OF INTOXICATION TO 

1757
01:10:17,902 --> 01:10:19,837
WITHDRAWAL TO THEN CRAVING.

1758
01:10:19,837 --> 01:10:22,573
OR RECOVERY.

1759
01:10:22,573 --> 01:10:24,675
BUT WE TEND TO, IN THE PAST, 

1760
01:10:24,675 --> 01:10:27,912
HAVE FOCUSED SPECIFICALLY ON 

1761
01:10:27,912 --> 01:10:28,179
TREATMENT.

1762
01:10:28,179 --> 01:10:29,813
HOW DO WE TREAT?

1763
01:10:29,813 --> 01:10:32,349
INVESTIGATING THAT STATE OF 

1764
01:10:32,349 --> 01:10:33,884
COMPULSIVE DRUG YUSZ.

1765
01:10:33,884 --> 01:10:36,587
INVESTING THE STATE OF WITHDRAW.

1766
01:10:36,587 --> 01:10:38,055
WE HAVE DONE MUCH LESS IN THE 

1767
01:10:38,055 --> 01:10:39,657
STATE OF RECOVERY.

1768
01:10:39,657 --> 01:10:42,493
THE BRAIN IS NEUROPLASTIC AND 

1769
01:10:42,493 --> 01:10:45,362
ACTUALLY TO WHAT EXTENT THE LIVE

1770
01:10:45,362 --> 01:10:46,730
CHANGES WHEN SOMEONE IS 

1771
01:10:46,730 --> 01:10:47,998
ADDICTED, WITH SOCIAL ISOLATION,

1772
01:10:47,998 --> 01:10:54,205
A LOSS OF JOB, BASICALLY 

1773
01:10:54,205 --> 01:10:56,106
DEPRIVATION THAT THE DISEASE 

1774
01:10:56,106 --> 01:10:59,009
EXERTS ON THEM, HOW DOES THAT IN

1775
01:10:59,009 --> 01:11:00,344
TURN AFFECT THEIR BRAIN?

1776
01:11:00,344 --> 01:11:02,179
SO UNDERSTANDING AND 

1777
01:11:02,179 --> 01:11:03,614
INVESTIGATING THAT PROCESS OF 

1778
01:11:03,614 --> 01:11:05,616
HOW -- WHAT DOES IT TAKE FOR THE

1779
01:11:05,616 --> 01:11:08,619
BRAIN TO RECOVER TO A STATE THAT

1780
01:11:08,619 --> 01:11:11,121
ACTUALLY IT CAN BECOME ENGAGED?

1781
01:11:11,121 --> 01:11:13,824
ALL OF THOSE STAGES ARE ACTUALLY

1782
01:11:13,824 --> 01:11:16,594
EXTREMELY IMPORTANT AREAS WITH 

1783
01:11:16,594 --> 01:11:18,963
RESPECT TO RESEARCH ON THE ONE 

1784
01:11:18,963 --> 01:11:19,163
HAND.

1785
01:11:19,163 --> 01:11:19,530
EXPANDING IT.

1786
01:11:19,530 --> 01:11:23,067
AND IMPORTANTLY, TO BUILD UP AND

1787
01:11:23,067 --> 01:11:26,303
TO INFORM ON MODELS OF CARE THAT

1788
01:11:26,303 --> 01:11:27,871
ACTUALLY DON'T JUST FOCUS ON 

1789
01:11:27,871 --> 01:11:28,172
ONE.

1790
01:11:28,172 --> 01:11:30,074
LET'S DO THE TREATMENT.

1791
01:11:30,074 --> 01:11:31,976
WE REALIZE IT IS IMPORTANT TO 

1792
01:11:31,976 --> 01:11:34,912
HAVE THE CONTINUITY OF QUARTER 

1793
01:11:34,912 --> 01:11:36,046
THAT WOULD HOPEFULLY LEAD 

1794
01:11:36,046 --> 01:11:38,849
SOMEONE TO SUSTAINED RECOVERY.

1795
01:11:38,849 --> 01:11:41,452
BUT IN THESE TRANSITIONS, THIS 

1796
01:11:41,452 --> 01:11:43,053
MODEL ALSO HIGHLIGHTS HOW 

1797
01:11:43,053 --> 01:11:45,689
CRUCIAL IT IS FOR ACTUALLY 

1798
01:11:45,689 --> 01:11:46,991
INTERVENTIONS TO PREVENT DRUG 

1799
01:11:46,991 --> 01:11:54,732
EXPOSURES AND DRUG ESCALATION TO

1800
01:11:54,732 --> 01:11:55,766
CURE.

1801
01:11:55,766 --> 01:11:56,400
GENETIC OR ENVIRONMENT FACTORS.

1802
01:11:56,400 --> 01:11:59,036
HAVING SAID THAT, I JUST WANT TO

1803
01:11:59,036 --> 01:12:02,273
MAKE EVERYBODY AWARE THAT IN 

1804
01:12:02,273 --> 01:12:04,208
JOINTLY WITH THE ALCOHOL 

1805
01:12:04,208 --> 01:12:06,777
INSTITUTE NIDA, NCI, VERY 

1806
01:12:06,777 --> 01:12:09,813
IMPORTANT PARTICIPANT, WE TASKED

1807
01:12:09,813 --> 01:12:11,415
THE NATIONAL ACADEMIES OF 

1808
01:12:11,415 --> 01:12:13,984
SCIENCE AND MEDICINE AND 

1809
01:12:13,984 --> 01:12:15,619
ENGINEERING TO WRITE A 

1810
01:12:15,619 --> 01:12:19,723
PREVENTION, TO DO A REPORT ON A 

1811
01:12:19,723 --> 01:12:21,191
PREVENTION INFRASTRUCTURE FOR 

1812
01:12:21,191 --> 01:12:22,393
MENTAL, EMOTIONAL AND BEHAVIORAL

1813
01:12:22,393 --> 01:12:25,062
DISORDERS THAT WAS RELEASED LAST

1814
01:12:25,062 --> 01:12:29,266
MONTH AND THAT EMPHASIZES AREAS 

1815
01:12:29,266 --> 01:12:31,602
THAT ARE CRUCIAL IN TERMS OF 

1816
01:12:31,602 --> 01:12:33,804
RESEARCH AND INCLUDING THE 

1817
01:12:33,804 --> 01:12:36,206
IMPORTANCE OF COLLECTING DATA, 

1818
01:12:36,206 --> 01:12:38,108
BUT ALSO IDENTIFIED 

1819
01:12:38,108 --> 01:12:41,078
OPPORTUNITIES FOR POLICIES TO 

1820
01:12:41,078 --> 01:12:42,780
GENERATE AN INFRASTRUCTURE THAT 

1821
01:12:42,780 --> 01:12:44,748
WILL ALLOW EVIDENCE-BASED 

1822
01:12:44,748 --> 01:12:50,988
PREVENTIONS TO ACTUALLY BE 

1823
01:12:50,988 --> 01:12:52,256
DEPLOYED AND SUSTAINED IN 

1824
01:12:52,256 --> 01:12:54,158
DIVERSE COMMUNITIES SO WE CAN 

1825
01:12:54,158 --> 01:12:56,026
ADDRESS THE DEVASTATING 

1826
01:12:56,026 --> 01:12:59,596
CONSEQUENCES THAT SUBSTANCE USE 

1827
01:12:59,596 --> 01:13:00,531
AND BEHAVIORAL HEALTH DISORDERS 

1828
01:13:00,531 --> 01:13:03,734
HAVE ON THE LIFE OF AN 

1829
01:13:03,734 --> 01:13:04,034
INDIVIDUAL.

1830
01:13:04,034 --> 01:13:07,638
AND WITH THAT, I END MY 

1831
01:13:07,638 --> 01:13:08,238
PRESENTATION AND I'M GOING TO 

1832
01:13:08,238 --> 01:13:15,312
STOP SHARING.

1833
01:13:15,312 --> 01:13:16,980
I DO NOT KNOW IF THERE IS TIME 

1834
01:13:16,980 --> 01:13:19,083
FOR QUESTIONS OR NOT.

1835
01:13:19,083 --> 01:13:21,018
>> I THINK WE CAN TAKE A
FEW 

1836
01:13:21,018 --> 01:13:28,325
MINUTES FOR QUESTIONS.

1837
01:13:28,325 --> 01:13:30,361
ANY QUESTIONS FROM COUNCIL 

1838
01:13:30,361 --> 01:13:30,594
MEMBERS.

1839
01:13:30,594 --> 01:13:34,431
>> YES A QUESTION FROM
ISABELLE 

1840
01:13:34,431 --> 01:13:36,533
DURAN.

1841
01:13:36,533 --> 01:13:40,437
>> THANK YOU VERY MUCH,
DR. 

1842
01:13:40,437 --> 01:13:40,671
VOLKOW.

1843
01:13:40,671 --> 01:13:42,873
I REALLY ENJOYED THAT 

1844
01:13:42,873 --> 01:13:44,007
PRESENTATION PARTICULARLY A 

1845
01:13:44,007 --> 01:13:46,043
CONCEPT TO ME OF WHOLE PERSON 

1846
01:13:46,043 --> 01:13:46,510
CARE.

1847
01:13:46,510 --> 01:13:48,112
CANCER DOESN'T BEGIN AT THE 

1848
01:13:48,112 --> 01:13:49,179
CLINIC DOOR.

1849
01:13:49,179 --> 01:13:50,581
COMMUNITY AND SOCIAL 

1850
01:13:50,581 --> 01:13:56,653
DETERMINANTS OF HEALTH THAT 

1851
01:13:56,653 --> 01:14:00,591
IMPACT DISEASE.

1852
01:14:00,591 --> 01:14:05,462
A  IT IS MULTIPLE THINGS THAT 

1853
01:14:05,462 --> 01:14:06,230
CREATE THE RISK.

1854
01:14:06,230 --> 01:14:09,233
I HAVE A FEW QUESTIONS, SO 

1855
01:14:09,233 --> 01:14:10,501
PARDON THE TWO OR THREE 

1856
01:14:10,501 --> 01:14:11,835
QUESTIONS I HAVE THE OPPORTUNITY

1857
01:14:11,835 --> 01:14:12,536
TO ASK YOU.

1858
01:14:12,536 --> 01:14:14,705
IN TERMS OF THIS, EDUCATION IS 

1859
01:14:14,705 --> 01:14:16,673
MOST CRITICAL.

1860
01:14:16,673 --> 01:14:22,479
IS THE INSTITUTE POINTING 

1861
01:14:22,479 --> 01:14:23,781
OUTWARDS TO GET EDUCATIONAL 

1862
01:14:23,781 --> 01:14:25,082
INFORMATION TO GRADE SCHOOLS 

1863
01:14:25,082 --> 01:14:26,884
STARTING AT GRADE SCHOOLS TO 

1864
01:14:26,884 --> 01:14:29,019
INTERVENE INTO TAKING UP THE USE

1865
01:14:29,019 --> 01:14:34,057
OF OPIOIDS OR WHATEVER.

1866
01:14:34,057 --> 01:14:36,860
THEY ARE STRESSED OR IMPACTED OR

1867
01:14:36,860 --> 01:14:38,128
MODELLED BY SOMETHING ELSE.

1868
01:14:38,128 --> 01:14:40,030
THAT IS THE ONE THING.

1869
01:14:40,030 --> 01:14:40,297
EDUCATION.

1870
01:14:40,297 --> 01:14:42,132
CAN YOU GO TO THE DEPARTMENT OF 

1871
01:14:42,132 --> 01:14:44,067
EDUCATION AND SAY LET'S START AN

1872
01:14:44,067 --> 01:14:44,935
EDUCATION PROGRAM THAT GOES TO 

1873
01:14:44,935 --> 01:14:47,137
ALL OF THE SCHOOLS, PARTICULARLY

1874
01:14:47,137 --> 01:14:47,938
THE MOST VULNERABLE.

1875
01:14:47,938 --> 01:14:49,706
SO THAT IS ONE.

1876
01:14:49,706 --> 01:14:51,074
THE SECOND THING IS I WAS 

1877
01:14:51,074 --> 01:14:53,544
TALKING TO A RESEARCHER WHO WAS 

1878
01:14:53,544 --> 01:14:55,646
DOING A RESEARCH PROJECT IN 

1879
01:14:55,646 --> 01:14:57,514
PHILADELPHIA WITH LATINO KIDS 

1880
01:14:57,514 --> 01:14:58,982
WHO WERE VAPING.

1881
01:14:58,982 --> 01:15:02,252
AND ONE OF THE THINGS HE ASKED 

1882
01:15:02,252 --> 01:15:05,088
THEM WAS THE FACT THAT THIS IS 

1883
01:15:05,088 --> 01:15:06,824
AN EXPENSIVE KIND OF HABIT.

1884
01:15:06,824 --> 01:15:08,692
HOW ARE YOU AFFORDING IT?

1885
01:15:08,692 --> 01:15:11,595
AND THEY SAID THEY WERE SHARING.

1886
01:15:11,595 --> 01:15:15,566
THAT RAISED ISSUES WITH ME 

1887
01:15:15,566 --> 01:15:19,870
ABOUT -- BY SHARING THESE 

1888
01:15:19,870 --> 01:15:21,505
CIGARETTES, WHAT IMPACTS 

1889
01:15:21,505 --> 01:15:22,906
LONG-TERM COULD THEY POSSIBLE 

1890
01:15:22,906 --> 01:15:23,207
HAVE?

1891
01:15:23,207 --> 01:15:26,543
COULD THEY HAVE ANY?

1892
01:15:26,543 --> 01:15:28,378
THERE IS ANOTHER ASPECT OF 

1893
01:15:28,378 --> 01:15:28,745
EDUCATION.

1894
01:15:28,745 --> 01:15:29,379
DON'T SHARE.

1895
01:15:29,379 --> 01:15:32,783
YOU MIGHT BE PASSING IT AROUND.

1896
01:15:32,783 --> 01:15:37,054
THIRDLY DO YOU HAVE 

1897
01:15:37,054 --> 01:15:37,788
DISAGGREGATED SUB POPULATION 

1898
01:15:37,788 --> 01:15:39,690
DATA SO I CAN LOOK AT THIS DATA 

1899
01:15:39,690 --> 01:15:42,993
AND KNOW WHAT I CAN TELL THE 

1900
01:15:42,993 --> 01:15:44,328
LATINO COMMUNITY ABOUT THESE 

1901
01:15:44,328 --> 01:15:45,796
ISSUES, HOW THEY ARE IMPACTING 

1902
01:15:45,796 --> 01:15:48,232
THEM AND WHAT WE NEED TO DO TO 

1903
01:15:48,232 --> 01:15:50,000
INTERVENE AS COMMUNITIES, AS 

1904
01:15:50,000 --> 01:15:53,770
FAMILIES, AS INDIVIDUALS.

1905
01:15:53,770 --> 01:15:55,339
>> VERY IMPORTANT QUESTION
AND 

1906
01:15:55,339 --> 01:15:57,908
YOU ARE POINTING YOUR FINGER ON 

1907
01:15:57,908 --> 01:15:59,776
EXACTLY ONE OF OUR MAIN TARGETS 

1908
01:15:59,776 --> 01:16:00,711
FOR INTERVENTION AND THAT IS 

1909
01:16:00,711 --> 01:16:01,278
EDUCATION AND GOING TO THE 

1910
01:16:01,278 --> 01:16:02,913
SCHOOLS.

1911
01:16:02,913 --> 01:16:05,282
I WAS ACTUALLY SMILING AT THAT 

1912
01:16:05,282 --> 01:16:07,518
AND LOOKING AT GEORGE BECAUSE HE

1913
01:16:07,518 --> 01:16:08,852
WAS SMILING ALSO.

1914
01:16:08,852 --> 01:16:10,187
WOE DEFINITELY BOTH OF OUR 

1915
01:16:10,187 --> 01:16:11,989
INSTITUTES HAVE REACHED OUT TO 

1916
01:16:11,989 --> 01:16:13,056
THE DEPARTMENT OF EDUCATION TO 

1917
01:16:13,056 --> 01:16:16,360
MAKE THEM AWARE OF THE 

1918
01:16:16,360 --> 01:16:17,628
IMPORTANCE OF CURRICULA THAT 

1919
01:16:17,628 --> 01:16:21,498
RELATE TO EDUCATION, BUT ALSO 

1920
01:16:21,498 --> 01:16:23,967
PROGRAMS THAT HAVE BEEN SHOWN 

1921
01:16:23,967 --> 01:16:25,869
FOR WHICH THE EVIDENCE 

1922
01:16:25,869 --> 01:16:27,838
INDICATES, PROGRAMS BASED ON 

1923
01:16:27,838 --> 01:16:29,439
SCHOOL, THEY SIGNIFICANTLY 

1924
01:16:29,439 --> 01:16:34,912
IMPROVE THE OUTCOMES.

1925
01:16:34,912 --> 01:16:35,979
UNFORTUNATELY, THERE HAS NOT 

1926
01:16:35,979 --> 01:16:38,248
BEEN MUCH RECEPTIVENESS.

1927
01:16:38,248 --> 01:16:40,183
PART OF IT IS THE CURRICULUM IS 

1928
01:16:40,183 --> 01:16:41,885
ALREADY SO HEAVY THEY DON'T SEE 

1929
01:16:41,885 --> 01:16:43,887
WAYS IN WHICH IT CAN BE 

1930
01:16:43,887 --> 01:16:44,221
INCORPORATED.

1931
01:16:44,221 --> 01:16:45,856
SO THIS IS A PROBLEM.

1932
01:16:45,856 --> 01:16:48,025
AND I DO HOPE -- WE WERE HOPING 

1933
01:16:48,025 --> 01:16:49,893
THAT WITH THE RELEASE OF THE 

1934
01:16:49,893 --> 01:16:51,128
REPORT FROM THE NATIONAL 

1935
01:16:51,128 --> 01:16:53,764
ACADEMY, THIS WILL BRING 

1936
01:16:53,764 --> 01:16:56,199
ATTENTION TO PREVENTION, 

1937
01:16:56,199 --> 01:16:57,568
INCLUDING BUY-IN FROM THE 

1938
01:16:57,568 --> 01:16:58,235
EDUCATIONAL SYSTEM.

1939
01:16:58,235 --> 01:16:59,503
BECAUSE IT IS AN EXTREMELY 

1940
01:16:59,503 --> 01:17:00,270
IMPORTANT ONE.

1941
01:17:00,270 --> 01:17:01,438
THAT IS ONE.

1942
01:17:01,438 --> 01:17:03,006
THE OTHER ONE AND I DISCUSSED 

1943
01:17:03,006 --> 01:17:04,107
THIS YESTERDAY, WAS THE WHOLE 

1944
01:17:04,107 --> 01:17:07,110
ISSUE OF THE FAMILIES.

1945
01:17:07,110 --> 01:17:08,579
FAMILIES ALSO, TWO VERY 

1946
01:17:08,579 --> 01:17:09,813
IMPORTANT LINE OF DEFENSE WE 

1947
01:17:09,813 --> 01:17:10,013
HAVE.

1948
01:17:10,013 --> 01:17:11,048
NUMBER ONE IS FAMILIES.

1949
01:17:11,048 --> 01:17:13,850
NUMBER TWO IS SCHOOLS.

1950
01:17:13,850 --> 01:17:15,686
AND WE NEED TO EDUCATE BOTH IN 

1951
01:17:15,686 --> 01:17:18,989
THE SCHOOL AND IN THE FAMILY.

1952
01:17:18,989 --> 01:17:21,358
AND THAT IS A MESSAGE WE WILL 

1953
01:17:21,358 --> 01:17:23,527
CONTINUE CARRYING ON BECAUSE IT 

1954
01:17:23,527 --> 01:17:24,227
IS ACTUALLY, YOU KNOW, WHEN 

1955
01:17:24,227 --> 01:17:25,629
PEOPLE SAY, WELL, THERE'S NO 

1956
01:17:25,629 --> 01:17:27,864
TIME OR THERE'S NO RESOURCES.

1957
01:17:27,864 --> 01:17:29,666
THE ISSUE IS HOW YOU PRIORITIZE 

1958
01:17:29,666 --> 01:17:30,634
YOUR TIME.

1959
01:17:30,634 --> 01:17:33,704
HOW YOU PRIORITIZE YOUR 

1960
01:17:33,704 --> 01:17:34,438
RESOURCES.

1961
01:17:34,438 --> 01:17:36,106
AND NOW WITH OTHER TECHNOLOGIES 

1962
01:17:36,106 --> 01:17:38,542
WE CAN DELIVER SOME OF THE 

1963
01:17:38,542 --> 01:17:42,746
INTERVENTIONS IN H  WAYS THAT 

1964
01:17:42,746 --> 01:17:44,147
ARE MUCH MORE ACCESSIBLE TO 

1965
01:17:44,147 --> 01:17:44,414
EVERYONE.

1966
01:17:44,414 --> 01:17:46,383
WHICH COMES BACK TO YOUR 

1967
01:17:46,383 --> 01:17:48,218
QUESTION ABOUT DISAGGREGATED 

1968
01:17:48,218 --> 01:17:48,518
INFORMATION.

1969
01:17:48,518 --> 01:17:49,820
THE ANSWER IS YES.

1970
01:17:49,820 --> 01:17:52,222
IN FACT, RESEARCHERS HAVE BEEN 

1971
01:17:52,222 --> 01:17:55,125
WORKING TO INVESTIGATE WHAT ARE 

1972
01:17:55,125 --> 01:17:56,593
FACTORS AND INTERVENTIONS THAT 

1973
01:17:56,593 --> 01:17:58,395
MAY WORK BETTER IN CERTAIN 

1974
01:17:58,395 --> 01:17:59,463
GROUPS OR OTHER.

1975
01:17:59,463 --> 01:18:02,032
ONE OF THE STRENGTHS AND 

1976
01:18:02,032 --> 01:18:05,769
RESILIENCY FACTORS OF SERVING 

1977
01:18:05,769 --> 01:18:09,439
CERTAIN COMMUNITIES LIKE THAT OF

1978
01:18:09,439 --> 01:18:10,507
HISPANICS, IS VERY MUCH AMONG 

1979
01:18:10,507 --> 01:18:12,009
BLACK AMERICANS IS THAT OF THE 

1980
01:18:12,009 --> 01:18:12,409
FAMILY STRUCTURE.

1981
01:18:12,409 --> 01:18:15,479
IN THE LATINO FAMILY STRUCTURE 

1982
01:18:15,479 --> 01:18:18,248
YOU HAVE THESE VERY CLOSE TIES.

1983
01:18:18,248 --> 01:18:19,483
THAT PROVIDES A SUPPORT SYSTEM 

1984
01:18:19,483 --> 01:18:23,086
YOU CAN, IF USED PROPERLY, CAN 

1985
01:18:23,086 --> 01:18:24,221
HELP NAVIGATE THOSE TEENAGERS 

1986
01:18:24,221 --> 01:18:25,255
AND PROTECT THEM.

1987
01:18:25,255 --> 01:18:26,289
SAME THING WITH BLACK 

1988
01:18:26,289 --> 01:18:28,458
COMMUNITIES AND WHAT WE SEE IS 

1989
01:18:28,458 --> 01:18:31,561
IN GENERAL OVERALL IN BLACK 

1990
01:18:31,561 --> 01:18:37,000
TEENAGERS, THEY ACTUALLY IN 

1991
01:18:37,000 --> 01:18:38,669
GENERAL, THEY TEND TO HAVE LOWER

1992
01:18:38,669 --> 01:18:40,737
RISK UNTIL THEY START TO REACH 

1993
01:18:40,737 --> 01:18:43,440
THEIR LATE TEENS WHEN THEY 

1994
01:18:43,440 --> 01:18:44,574
TRANSITION INTO ADULTHOOD AND 

1995
01:18:44,574 --> 01:18:46,643
THE FAMILY IS NO LONGER THERE.

1996
01:18:46,643 --> 01:18:47,878
I THINK THE DATA IS ALREADY 

1997
01:18:47,878 --> 01:18:48,478
THERE.

1998
01:18:48,478 --> 01:18:52,983
THE EVIDENCE IS ALREADY THERE.

1999
01:18:52,983 --> 01:18:54,451
WE WOULD HOPE THAT THERE WOULD 

2000
01:18:54,451 --> 01:18:57,554
BE POLICIES THAT PROVIDE SUPPORT

2001
01:18:57,554 --> 01:19:00,290
FOR INTERVENTIONS THAT ACTUALLY 

2002
01:19:00,290 --> 01:19:02,826
ARE GOING TO BE CULTURALLY 

2003
01:19:02,826 --> 01:19:03,894
SENSITIVE SO OTHERWISE PEOPLE 

2004
01:19:03,894 --> 01:19:06,096
DON'T ACCEPT THEM, DON'T EMBRACE

2005
01:19:06,096 --> 01:19:08,098
THEM AND I THINK THAT IS A KEY 

2006
01:19:08,098 --> 01:19:08,331
ELEMENT.

2007
01:19:08,331 --> 01:19:12,936
YOU HAD A SECOND QUESTION IN 

2008
01:19:12,936 --> 01:19:13,170
BETWEEN.

2009
01:19:13,170 --> 01:19:14,471
BUT I BLOCK IT.

2010
01:19:14,471 --> 01:19:18,341
>> ONE THING YOU DIDN'T
ANSWER, 

2011
01:19:18,341 --> 01:19:19,976
THANK YOU FOR REMEMBERING THE 

2012
01:19:19,976 --> 01:19:20,243
QUESTION.

2013
01:19:20,243 --> 01:19:22,512
THIS ONE IS THE FACT THEY ARE 

2014
01:19:22,512 --> 01:19:24,181
SHARING THEIR ELECTRONIC 

2015
01:19:24,181 --> 01:19:25,382
CIGARETTES.

2016
01:19:25,382 --> 01:19:27,551
THAT POSES LONG-TERM ISSUES OF 

2017
01:19:27,551 --> 01:19:29,186
OTHER DISEASE TYPES OR ANY 

2018
01:19:29,186 --> 01:19:30,821
ISSUES THAT NEED TO BE 

2019
01:19:30,821 --> 01:19:31,088
ADDRESSED.

2020
01:19:31,088 --> 01:19:31,722
>> I KNOW.

2021
01:19:31,722 --> 01:19:33,724
WHEN YOU WERE SPEAKING ABOUT IT,

2022
01:19:33,724 --> 01:19:35,325
YES, WE KNOW THAT RIGHT NOW.

2023
01:19:35,325 --> 01:19:36,827
YOU WORDED IT VERY WELL.

2024
01:19:36,827 --> 01:19:38,562
THAT IS THE MESSAGE IS DO NOT 

2025
01:19:38,562 --> 01:19:39,329
SHARE YOUR DRUGS.

2026
01:19:39,329 --> 01:19:40,931
BECAUSE TO START WITH, YOU DO 

2027
01:19:40,931 --> 01:19:42,299
NOT KNOW WHAT YOU ARE GOING TO 

2028
01:19:42,299 --> 01:19:43,133
GET.

2029
01:19:43,133 --> 01:19:44,901
THIS IS A MESSAGE THAT WE HAVE 

2030
01:19:44,901 --> 01:19:47,838
BEEN DOING PREDOMINANTLY WITH 

2031
01:19:47,838 --> 01:19:49,072
PRESCRIPTION DRUGS WHERE KIDS 

2032
01:19:49,072 --> 01:19:50,807
MAY TAKE A FRIEND GIVES THEM A 

2033
01:19:50,807 --> 01:19:53,610
PRESCRIPTION DRUG TO GET HIGH 

2034
01:19:53,610 --> 01:19:54,211
ON.

2035
01:19:54,211 --> 01:19:57,380
AND THEN IT IS A SUBSTANCE THAT 

2036
01:19:57,380 --> 01:19:58,515
CONTAINS FENTANYL AND THEY 

2037
01:19:58,515 --> 01:19:58,782
OVERDOSE.

2038
01:19:58,782 --> 01:20:01,585
WITH VAPING, YOU CAN ACTUALLY 

2039
01:20:01,585 --> 01:20:04,221
MIX A WIDE VARIETY OF SUBSTANCES

2040
01:20:04,221 --> 01:20:05,856
PLUS THE CONCENTRATION OF SOME 

2041
01:20:05,856 --> 01:20:07,924
OF THOSE VAPING DEVICES IS 

2042
01:20:07,924 --> 01:20:09,459
EXTREMELY HIGH.

2043
01:20:09,459 --> 01:20:10,627
FOR A TEENAGER THAT DOESN'T HAVE

2044
01:20:10,627 --> 01:20:12,429
THE EXPERIENCE, THIS COULD 

2045
01:20:12,429 --> 01:20:15,932
ACTUALLY LEAD TO POISONING.

2046
01:20:15,932 --> 01:20:18,235
SO, INDEED, JUST FROM THE 

2047
01:20:18,235 --> 01:20:21,171
PERSPECTIVE OF THE RISK THAT 

2048
01:20:21,171 --> 01:20:25,475
EXISTS, BY DRUG MIXTURES, THE 

2049
01:20:25,475 --> 01:20:26,510
MESSAGE SHOULD BE THAT ONE.

2050
01:20:26,510 --> 01:20:31,448
DO NOT SHARE DRUGS.

2051
01:20:31,448 --> 01:20:31,915
>> THANK YOU.

2052
01:20:31,915 --> 01:20:33,016
>> OKAY.

2053
01:20:33,016 --> 01:20:35,385
SO I THINK WE SHOULD MOVE ON.

2054
01:20:35,385 --> 01:20:37,554
THOSE ARE GREAT QUESTIONS AND 

2055
01:20:37,554 --> 01:20:41,458
GREAT DISCUSSION AND GREAT TALK 

2056
01:20:41,458 --> 01:20:47,030
BY NORA.

2057
01:20:47,030 --> 01:20:49,399
WE WILL HAVE TIME LATER FOR MORE

2058
01:20:49,399 --> 01:20:49,699
DISCUSSION.

2059
01:20:49,699 --> 01:20:51,268
SO SAVE YOUR THOUGHTS FOR 

2060
01:20:51,268 --> 01:20:52,803
DISCUSSIONS WE WILL HAVE LATER 

2061
01:20:52,803 --> 01:20:52,969
ON.

2062
01:20:52,969 --> 01:20:55,705
OUR NEXT SPEAKER IS DR. KLEIN, 

2063
01:20:55,705 --> 01:20:57,874
THE ASSOCIATE DIRECTOR OF NCI'S 

2064
01:20:57,874 --> 01:21:00,210
BEHAVIORAL RESEARCH PROGRAM AND 

2065
01:21:00,210 --> 01:21:04,314
BILL IS GOING TO TALK ABOUT 

2066
01:21:04,314 --> 01:21:05,682
CRAN-RELATED NATIONAL CANCER 

2067
01:21:05,682 --> 01:21:07,717
INSTITUTE ACTIVITIES AND 

2068
01:21:07,717 --> 01:21:08,018
PRIORITIES.

2069
01:21:08,018 --> 01:21:18,428
SO BILL, IT'S ALL YOURS.

2070
01:21:24,768 --> 01:21:26,403
>> GOOD MORNING,
EVERYBODY.

2071
01:21:26,403 --> 01:21:31,041
THANK YOU GEORGE AND NORA.

2072
01:21:31,041 --> 01:21:32,375
I'M GOING TO RIFF OFF THOSE 

2073
01:21:32,375 --> 01:21:32,709
PRESENTATIONS.

2074
01:21:32,709 --> 01:21:35,045
I'M A JAZZ MUSICIAN SO RIFFING 

2075
01:21:35,045 --> 01:21:35,912
IS MY COMFORT ZONE.

2076
01:21:35,912 --> 01:21:37,547
I WANT TO GIVE YOU A SENSE OF 

2077
01:21:37,547 --> 01:21:39,716
WHAT WE HAVE BEEN DOING, 

2078
01:21:39,716 --> 01:21:40,517
THINKING ABOUT AT NCI WITH 

2079
01:21:40,517 --> 01:21:41,852
REGARD TO THE PRIORITIES OF 

2080
01:21:41,852 --> 01:21:42,052
CRAN.

2081
01:21:42,052 --> 01:21:44,421
I WANT TO START WITH SOME RECENT

2082
01:21:44,421 --> 01:21:44,788
UPDATES.

2083
01:21:44,788 --> 01:21:46,489
FIRST OF ALL, I WANT TO 

2084
01:21:46,489 --> 01:21:47,757
EMPHASIZE AND THERE IS PROBABLY 

2085
01:21:47,757 --> 01:21:49,326
NO BETTER TIME TO EMPHASIZE 

2086
01:21:49,326 --> 01:21:51,194
THIS, THAT WE HAVE LOTS OF DATA 

2087
01:21:51,194 --> 01:21:52,796
SETS TO THE EXTRA MURAL 

2088
01:21:52,796 --> 01:21:54,197
COMMUNITY AND THEY ARE STILL 

2089
01:21:54,197 --> 01:21:54,397
THERE.

2090
01:21:54,397 --> 01:21:55,966
DON'T TAKE THEM FOR GRANTED.

2091
01:21:55,966 --> 01:21:58,602
ONE OF THEM IS THE TOBACCO USE 

2092
01:21:58,602 --> 01:21:59,603
SUPPLEMENT TO THE CURRENT 

2093
01:21:59,603 --> 01:22:01,872
POPULATION SURVEY.

2094
01:22:01,872 --> 01:22:04,441
THIS IS A VERY LARGE DATA SET, 

2095
01:22:04,441 --> 01:22:06,509
TENS OF THOUSANDS OF PEOPLE ARE 

2096
01:22:06,509 --> 01:22:07,544
RESPONDING TO THESE SURVEYS.

2097
01:22:07,544 --> 01:22:12,215
WE HAVE THE DATA FROM THE MOST 

2098
01:22:12,215 --> 01:22:17,187
RECENT ITERATION PUBLICLY 

2099
01:22:17,187 --> 01:22:20,790
AVAILABLE.

2100
01:22:20,790 --> 01:22:24,194
ONE OF OUR BRANCH RETURNED FROM 

2101
01:22:24,194 --> 01:22:26,062
A EMBASSY SCIENCE FELLOWSHIP 

2102
01:22:26,062 --> 01:22:32,302
WORKING WITH THE FRENCH 

2103
01:22:32,302 --> 01:22:33,737
GOVERNMENT.

2104
01:22:33,737 --> 01:22:36,973
THE WAY THEY ARE ADDRESSING THEM

2105
01:22:36,973 --> 01:22:40,410
IS USEFUL.

2106
01:22:40,410 --> 01:22:42,345
CAROLYN REYES GUZMAN SPENT TIME 

2107
01:22:42,345 --> 01:22:46,716
WITH THEM TO HELP THEM WITH THE 

2108
01:22:46,716 --> 01:22:48,018
ALCOHOL AND TOBACCO PLAN.

2109
01:22:48,018 --> 01:22:49,586
WE HAVE HAD CHANGES IN THE 

2110
01:22:49,586 --> 01:22:51,655
TOBACCO CONTROL LANDSCAPE IN THE

2111
01:22:51,655 --> 01:22:52,188
LAST SEVERAL MONTHS.

2112
01:22:52,188 --> 01:22:53,890
THE OFFICE OF SMOKING AND HEALTH

2113
01:22:53,890 --> 01:22:55,492
AT THE CENTER FOR DISEASES 

2114
01:22:55,492 --> 01:22:58,328
CONTROL, CDC, HAS BEEN 

2115
01:22:58,328 --> 01:22:58,595
DISBANDED.

2116
01:22:58,595 --> 01:23:00,330
THAT WAS A BIG PART OF OUR 

2117
01:23:00,330 --> 01:23:01,298
TOBACCO CONTROL EFFORT IN THE 

2118
01:23:01,298 --> 01:23:01,698
U.S.

2119
01:23:01,698 --> 01:23:04,134
AS A RESULT OF THAT AND SOME 

2120
01:23:04,134 --> 01:23:05,702
OTHER CHANGES THAT HAVE 

2121
01:23:05,702 --> 01:23:07,304
OCCURRED, WE THINK IT IS REALLY 

2122
01:23:07,304 --> 01:23:08,338
IMPORTANT TO CONTINUE THE WORK 

2123
01:23:08,338 --> 01:23:11,808
OF THE DEPARTMENT OF HEALTH AND 

2124
01:23:11,808 --> 01:23:13,476
HUMAN SERVICES TOBACCO STEERING 

2125
01:23:13,476 --> 01:23:15,145
COMMITTEE AND THE FEDERAL 

2126
01:23:15,145 --> 01:23:16,079
CESSATION WORK GROUP.

2127
01:23:16,079 --> 01:23:20,216
WE FOLDED THEM INTO THE TOBACCO 

2128
01:23:20,216 --> 01:23:21,451
AND NICOTINE INTEREST GROUP AT 

2129
01:23:21,451 --> 01:23:21,751
NIH.

2130
01:23:21,751 --> 01:23:23,453
JUST WANTED TO LET YOU KNOW 

2131
01:23:23,453 --> 01:23:23,687
THAT.

2132
01:23:23,687 --> 01:23:24,654
THESE ARE PRIORITIES AND 

2133
01:23:24,654 --> 01:23:26,122
CONTINUE TO BE PRIORITIES AND 

2134
01:23:26,122 --> 01:23:27,657
WE'LL CONTINUE TO HAVE MEMBERS 

2135
01:23:27,657 --> 01:23:30,760
OF MULTIPLE AGENCIES INCLUDING 

2136
01:23:30,760 --> 01:23:33,029
NIH, INVOLVED IN THESE 

2137
01:23:33,029 --> 01:23:33,330
DISCUSSIONS.

2138
01:23:33,330 --> 01:23:34,931
ANOTHER DATA SET I WANT TO MAKE 

2139
01:23:34,931 --> 01:23:38,001
SURE YOU ARE AWARE OF, I WANT TO

2140
01:23:38,001 --> 01:23:39,102
HIGHLIGHT THE HEALTH INFORMATION

2141
01:23:39,102 --> 01:23:41,338
NATIONAL TREND SURVEY, WHICH WE 

2142
01:23:41,338 --> 01:23:42,472
CONDUCT ABOUT EVERY OTHER YEAR 

2143
01:23:42,472 --> 01:23:43,006
NOW.

2144
01:23:43,006 --> 01:23:45,608
WITH REGARD TO THIS PARTICULAR 

2145
01:23:45,608 --> 01:23:47,310
AUDIENCE, WE HAVE MULTIPLE 

2146
01:23:47,310 --> 01:23:49,746
MEASURES OF CANNABIS USE AND 

2147
01:23:49,746 --> 01:23:52,082
ATTITUDES ABOUT CANNABIS.

2148
01:23:52,082 --> 01:23:53,450
TOBACCO, OF COURSE, AND ALSO 

2149
01:23:53,450 --> 01:23:53,683
ALCOHOL.

2150
01:23:53,683 --> 01:23:55,719
AND MANY OTHER TOPICS AS YOU CAN

2151
01:23:55,719 --> 01:23:57,854
SEE IN THE LOWER BOX.

2152
01:23:57,854 --> 01:24:00,357
THESE SLIDES WILL BE AVAILABLE, 

2153
01:24:00,357 --> 01:24:02,292
SO I WON'T GO THROUGH THE ENTIRE

2154
01:24:02,292 --> 01:24:02,859
SLIDE.

2155
01:24:02,859 --> 01:24:05,395
THIS IS A TERRIFIC RESOURCE AND 

2156
01:24:05,395 --> 01:24:07,063
WE ENCOURAGE OUR EXTRA MURAL 

2157
01:24:07,063 --> 01:24:08,865
COMMUNITY TO USE IT.

2158
01:24:08,865 --> 01:24:11,434
WHEN I WAS A FACULTY MEMBER I 

2159
01:24:11,434 --> 01:24:13,737
HAD MY NEW STUDENTS DOWNLOAD 

2160
01:24:13,737 --> 01:24:16,439
THIS TO WORK ON IT AND GET A 

2161
01:24:16,439 --> 01:24:17,807
PUBLICATION IN THEIR FIRST YEAR.

2162
01:24:17,807 --> 01:24:20,744
WE HAVE NOW COMPLETED THE 2024 

2163
01:24:20,744 --> 01:24:22,679
FIELDING AND THOSE DATA ARE 

2164
01:24:22,679 --> 01:24:24,114
PUBLICLY AVAILABLE AS A FEW 

2165
01:24:24,114 --> 01:24:25,448
WEEKS AGO.

2166
01:24:25,448 --> 01:24:26,082
WE HOPE PEOPLE WILL TAKE 

2167
01:24:26,082 --> 01:24:27,283
ADVANTAGE OF THAT.

2168
01:24:27,283 --> 01:24:31,988
WE ARE ENGAGED IN A DATA LINKAGE

2169
01:24:31,988 --> 01:24:35,759
PROJECT TO LINK DATA TO OTHER 

2170
01:24:35,759 --> 01:24:36,693
SOURCES.

2171
01:24:36,693 --> 01:24:41,331
WE HAVE GEOCODES AND CAN LINK TO

2172
01:24:41,331 --> 01:24:42,232
POLICY IMPLEMENTATION IN THE 

2173
01:24:42,232 --> 01:24:43,633
LOCATIONS THEY ARE COMING FROM.

2174
01:24:43,633 --> 01:24:47,537
WE REACHED OUR 1,000th 

2175
01:24:47,537 --> 01:24:51,141
PUBLICATION FROM HINTS DATA.

2176
01:24:51,141 --> 01:24:54,310
THIS IS A SURVEY THAT HAS BEEN 

2177
01:24:54,310 --> 01:24:56,946
OUT SINCE 2002 SO THAT IS 

2178
01:24:56,946 --> 01:24:57,247
REMARKABLE.

2179
01:24:57,247 --> 01:24:58,681
LET'S TALK ABOUT THE ACTIONS WE 

2180
01:24:58,681 --> 01:24:59,549
ARE TAKING.

2181
01:24:59,549 --> 01:25:02,052
WE ARE CONSTANTLY TAKING A LOOK,

2182
01:25:02,052 --> 01:25:04,120
AS IS NIDA, AT TOBACCO USE.

2183
01:25:04,120 --> 01:25:06,189
YOU CAN SEE WE ARE SEEING A 

2184
01:25:06,189 --> 01:25:09,692
DECREASE IN FEMALES BUT NOT THE 

2185
01:25:09,692 --> 01:25:11,494
SAME KIND OF DECREASE IN MALES 

2186
01:25:11,494 --> 01:25:13,196
JUST LOOKING OVERALL.

2187
01:25:13,196 --> 01:25:15,432
THIS IS TOBACCO USERS IN THE 

2188
01:25:15,432 --> 01:25:15,965
BILLS.

2189
01:25:15,965 --> 01:25:17,667
THIS IS W.H.O. DATA.

2190
01:25:17,667 --> 01:25:19,569
WE WOULD LIKE TO THINK OUR 

2191
01:25:19,569 --> 01:25:21,404
PROBLEM IS GOING DOWN, BUT IT IS

2192
01:25:21,404 --> 01:25:22,906
NOT EXACTLY GOING DOWN.

2193
01:25:22,906 --> 01:25:24,307
WE KNOW FROM OTHER DATA TOBACCO 

2194
01:25:24,307 --> 01:25:26,342
USE IS REALLY HIGH IN 

2195
01:25:26,342 --> 01:25:29,512
POPULATIONS SUCH AS PEOPLE WITH 

2196
01:25:29,512 --> 01:25:30,346
MENTAL HEALTH DIAGNOSES, PEOPLE 

2197
01:25:30,346 --> 01:25:31,481
IN THE MILITARY, LGBTQ+ AND SO 

2198
01:25:31,481 --> 01:25:34,084
ON.

2199
01:25:34,084 --> 01:25:35,819
THE LEADING CAUSES OF CANCER 

2200
01:25:35,819 --> 01:25:38,354
DEATHS THAT WE SPEND A LOT OF 

2201
01:25:38,354 --> 01:25:42,058
TIME TALKING ABOUT TOBACCO USE 

2202
01:25:42,058 --> 01:25:44,294
IN THE CONCEPT OF CANCER.

2203
01:25:44,294 --> 01:25:48,598
LUNG AND BRONCHIALS IS AT THE 

2204
01:25:48,598 --> 01:25:48,765
TOP.

2205
01:25:48,765 --> 01:25:50,533
IF YOU WERE TO CUT THE NUMBERS 

2206
01:25:50,533 --> 01:25:53,937
IN HALF, IN TERMS OF LUNG AND 

2207
01:25:53,937 --> 01:25:56,039
BRONCHUS, YOU STILL HAVE THE 

2208
01:25:56,039 --> 01:25:57,607
LEADING CAUSE OF CANCER DEATH, 

2209
01:25:57,607 --> 01:25:58,274
10%.

2210
01:25:58,274 --> 01:26:01,211
IT SHOWS HOW POWERFUL THE 

2211
01:26:01,211 --> 01:26:03,313
EFFECTS ARE OF TOBACCO ON CANCER

2212
01:26:03,313 --> 01:26:05,148
MORBIDITY AND MORTALITY AND THE 

2213
01:26:05,148 --> 01:26:07,584
IMPORTANCE OF ADDRESSING IT.

2214
01:26:07,584 --> 01:26:10,787
TAKING A LOOK MORE SPECIFICALLY 

2215
01:26:10,787 --> 01:26:12,722
AT DIFFERENT AGE GROUPS AND USE 

2216
01:26:12,722 --> 01:26:13,723
OF TOBACCO.

2217
01:26:13,723 --> 01:26:15,825
IN THE LEFT MOST COLUMN THE 

2218
01:26:15,825 --> 01:26:17,227
NUMBERS HAVE COME DOWN SOMEWHAT.

2219
01:26:17,227 --> 01:26:18,428
THEY ARE STILL TOO HIGH.

2220
01:26:18,428 --> 01:26:20,163
THEY ARE STILL HIGHER THAN WE 

2221
01:26:20,163 --> 01:26:21,431
WOULD LIKE THEM TO BE.

2222
01:26:21,431 --> 01:26:24,200
IT BREAKS DOWN BY AGE GROUP IN 

2223
01:26:24,200 --> 01:26:25,201
TERMS OF THE TYPE OF PRODUCT 

2224
01:26:25,201 --> 01:26:27,837
THEY ARE USING.

2225
01:26:27,837 --> 01:26:38,348
SECOND COLUMN 45-64, IN 

2226
01:26:40,283 --> 01:26:43,219
18-24-YEAR-OLDS THE BIG NEWS IS 

2227
01:26:43,219 --> 01:26:43,553
E-CIGARETTES.

2228
01:26:43,553 --> 01:26:45,655
IT IS CONTINUING OVER TIME AND 

2229
01:26:45,655 --> 01:26:49,726
WE NEED TO CONTINUE TO MONITOR 

2230
01:26:49,726 --> 01:26:54,697
THROUGH THE SURVEY AND 

2231
01:26:54,697 --> 01:26:57,433
POPULATION ON HEALTH, THE HAT 

2232
01:26:57,433 --> 01:26:57,967
STUDY.

2233
01:26:57,967 --> 01:26:58,868
OBVIOUSLY TOBACCO AND CANNABIS 

2234
01:26:58,868 --> 01:27:00,336
NEED TO BE THOUGHT OF IN THE 

2235
01:27:00,336 --> 01:27:01,638
SAME CONTEXT.

2236
01:27:01,638 --> 01:27:04,674
SO WHAT WE ARE SEEING NOW, THIS 

2237
01:27:04,674 --> 01:27:07,043
IS DATA FROM THE POPULATION 

2238
01:27:07,043 --> 01:27:08,211
ASSESSMENT OF TOBACCO AND 

2239
01:27:08,211 --> 01:27:09,078
HEALTH, WAVE SEVEN.

2240
01:27:09,078 --> 01:27:11,314
WE CAN SEE A VERY SMALL PORTION 

2241
01:27:11,314 --> 01:27:13,082
OF PEOPLE USING TOBACCO AND 

2242
01:27:13,082 --> 01:27:13,416
CANNABIS.

2243
01:27:13,416 --> 01:27:16,519
BUT IF YOU LOOK, THE LEFT MOST 

2244
01:27:16,519 --> 01:27:19,923
PIE THERE, THAT LITTLE BLUE 

2245
01:27:19,923 --> 01:27:23,293
PIECE, PULLING THAT OUT 

2246
01:27:23,293 --> 01:27:25,695
EXTRACTING IT AND LOOK AT WHO 

2247
01:27:25,695 --> 01:27:26,229
THOSE FOLKS ARE?

2248
01:27:26,229 --> 01:27:29,232
BLUE IN THE BIGGER PIE IS 

2249
01:27:29,232 --> 01:27:30,133
COMBUSTIBLE TOBACCO AND 

2250
01:27:30,133 --> 01:27:31,634
CANNABIS.

2251
01:27:31,634 --> 01:27:33,002
THAT IS THE BIGGEST PERCENTAGE 

2252
01:27:33,002 --> 01:27:34,437
USING TOGETHER.

2253
01:27:34,437 --> 01:27:36,406
COMBUSTIBLE PRODUCTS PRESENT 

2254
01:27:36,406 --> 01:27:37,073
MORE RISK.

2255
01:27:37,073 --> 01:27:39,342
THIS IS A VERY DENSE SLIDE.

2256
01:27:39,342 --> 01:27:41,511
I WON'T GO THROUGH ALL OF IT, IT

2257
01:27:41,511 --> 01:27:42,579
IS JUST IMPORTANT TO UNDERSTAND 

2258
01:27:42,579 --> 01:27:45,381
WHAT THIS OVERLAP LOOKS LIKE.

2259
01:27:45,381 --> 01:27:47,150
OUR TOBACCO CONTROL RESEARCH 

2260
01:27:47,150 --> 01:27:49,919
BRANCH OF NCI FOCUSED ALMOST 

2261
01:27:49,919 --> 01:27:50,620
EXCLUSIVELY ON TOBACCO.

2262
01:27:50,620 --> 01:27:52,889
WE NEED TO BE THINKING ABOUT 

2263
01:27:52,889 --> 01:27:53,556
CANNABIS AND ALCOHOL BECAUSE 

2264
01:27:53,556 --> 01:27:56,359
THESE SUBSTANCES ARE OFTEN USED 

2265
01:27:56,359 --> 01:27:56,726
TOGETHER.

2266
01:27:56,726 --> 01:27:57,827
WHAT DO PEOPLE THINK ABOUT 

2267
01:27:57,827 --> 01:27:59,062
CANNABIS USE?

2268
01:27:59,062 --> 01:28:00,930
IS OUR HEALTH INFORMATION 

2269
01:28:00,930 --> 01:28:02,298
NATIONAL TREND SURVEY DATA AS I 

2270
01:28:02,298 --> 01:28:04,867
MENTIONED BEFORE, WE DO MEASURE 

2271
01:28:04,867 --> 01:28:05,902
ATTITUDES ABOUT CANNABIS.

2272
01:28:05,902 --> 01:28:09,872
AS YOU CAN SEE IN THE PIE ON THE

2273
01:28:09,872 --> 01:28:10,873
LEFT, ALMOST 50% REPORT AT LEAST

2274
01:28:10,873 --> 01:28:12,308
SOME BENEFIT OF CANNABIS.

2275
01:28:12,308 --> 01:28:14,978
IT IS A VARIETY OF BENEFITS THEY

2276
01:28:14,978 --> 01:28:15,678
MIGHT SEE.

2277
01:28:15,678 --> 01:28:16,946
WE NEED TO ADDRESS THAT.

2278
01:28:16,946 --> 01:28:18,815
THIS IS NOT SOMETHING YOU SEE 

2279
01:28:18,815 --> 01:28:19,816
FOR TOBACCO.

2280
01:28:19,816 --> 01:28:22,452
MOST PEOPLE DO NOT SEE BENEFIT 

2281
01:28:22,452 --> 01:28:23,419
TO TOBACCO.

2282
01:28:23,419 --> 01:28:25,421
TOBACCO USERS SEE A BENEFIT AND 

2283
01:28:25,421 --> 01:28:27,023
ARE STILL TRYING TO QUIT.

2284
01:28:27,023 --> 01:28:30,260
THE FACT WE HAVE SUCH A LARGE 

2285
01:28:30,260 --> 01:28:31,928
PROPORTION OF THE POPULATION 

2286
01:28:31,928 --> 01:28:34,197
REPORTING BENEFIT OF CANNABIS, 

2287
01:28:34,197 --> 01:28:36,232
IT IS A DEBATABLE ISSUE BUT 

2288
01:28:36,232 --> 01:28:38,001
SOMETHING TO TAKE INTO ACCOUNT 

2289
01:28:38,001 --> 01:28:40,203
WITH CO-USE OF ALCOHOL AND 

2290
01:28:40,203 --> 01:28:40,470
CANNABIS.

2291
01:28:40,470 --> 01:28:41,938
ALCOHOL ASSUMPTION IS 

2292
01:28:41,938 --> 01:28:44,007
WIDESPREAD.

2293
01:28:44,007 --> 01:28:45,041
88% OF AMERICANS DRANK ALCOHOL 

2294
01:28:45,041 --> 01:28:47,577
AT SOME POINT IN THEIR 

2295
01:28:47,577 --> 01:28:49,012
LIFETIMES.

2296
01:28:49,012 --> 01:28:50,747
70% IN THE LAST YEAR.

2297
01:28:50,747 --> 01:28:52,415
WE ARE AT THE NATIONAL CANCER 

2298
01:28:52,415 --> 01:28:54,284
INSTITUTE AND THINK ABOUT BT 

2299
01:28:54,284 --> 01:28:57,387
WHAT THIS MEANS IN CANCER AND 

2300
01:28:57,387 --> 01:28:58,721
CANCER SURVIVORSHIP.

2301
01:28:58,721 --> 01:29:00,957
50% OF SURVIVORS ARE CURRENT 

2302
01:29:00,957 --> 01:29:03,426
DRINKING AND 35% EXCEED THE 

2303
01:29:03,426 --> 01:29:04,427
MODERATE DRINKING LIMITS.

2304
01:29:04,427 --> 01:29:07,063
THAT IS AN ISSUE KNOWING ALCOHOL

2305
01:29:07,063 --> 01:29:09,132
IS A RISK FACTOR FOR CANCER AS 

2306
01:29:09,132 --> 01:29:10,700
GEORGE MENTIONED.

2307
01:29:10,700 --> 01:29:13,870
WE KNOW LESS ABOUT HOW ALCOHOL 

2308
01:29:13,870 --> 01:29:15,238
INFLUENCES RECURRENCE AND 

2309
01:29:15,238 --> 01:29:17,373
SECONDARY CANCERS AND VERY 

2310
01:29:17,373 --> 01:29:19,509
LITTLE OF REDUCTION IN ALCOHOL 

2311
01:29:19,509 --> 01:29:21,477
REDUCES CANCER RISK IN CANCER 

2312
01:29:21,477 --> 01:29:22,078
SURVIVORS.

2313
01:29:22,078 --> 01:29:24,380
WE HAVE SOME EVIDENCE, BUT WE 

2314
01:29:24,380 --> 01:29:26,182
STILL NEED MORE DATA.

2315
01:29:26,182 --> 01:29:27,850
BOTTOM LINE IS THERE IS 

2316
01:29:27,850 --> 01:29:28,951
SOMETHING GOING ON HERE.

2317
01:29:28,951 --> 01:29:31,554
TO THE EXTEND WE HAVE CANCER 

2318
01:29:31,554 --> 01:29:37,493
SURVIVORS DRINKING CESSIVELY 

2319
01:29:37,493 --> 01:29:39,295
AND IT IS A PROBLEM THAT NEEDS 

2320
01:29:39,295 --> 01:29:41,297
TO BE ADDRESSED CLINICALLY, AND 

2321
01:29:41,297 --> 01:29:46,903
IT REALLY ISN'T.

2322
01:29:46,903 --> 01:29:48,571
THIS LEFT MOST COLUMN YOU CAN 

2323
01:29:48,571 --> 01:29:51,674
SEE TOBACCO IN THE 60s, 

2324
01:29:51,674 --> 01:29:53,443
AWARENESS OF THE LINK BETWEEN 

2325
01:29:53,443 --> 01:29:55,278
TOBACCO AND CANCER WAS 40%.

2326
01:29:55,278 --> 01:29:58,848
IN 2022 UP AROUND 90%.

2327
01:29:58,848 --> 01:30:00,183
LOOK WHERE WE ARE WITH ALCOHOL 

2328
01:30:00,183 --> 01:30:03,052
IN THE SAME YEAR, 2022.

2329
01:30:03,052 --> 01:30:03,219
32%.

2330
01:30:03,219 --> 01:30:05,788
I HAVE SEEN NUMBERS BETWEEN 30% 

2331
01:30:05,788 --> 01:30:06,422
AND 40%.

2332
01:30:06,422 --> 01:30:07,156
SOME HIGHER.

2333
01:30:07,156 --> 01:30:09,892
BUT THE NUMBERS ARE USUALLY 

2334
01:30:09,892 --> 01:30:10,626
BELOW 50%.

2335
01:30:10,626 --> 01:30:12,161
HALF OF THE POPULATION WOULD BE 

2336
01:30:12,161 --> 01:30:14,030
NICE AND WE ARE NOT THERE SEEING

2337
01:30:14,030 --> 01:30:16,199
THE LINK BETWEEN ALCOHOL AND 

2338
01:30:16,199 --> 01:30:16,499
CANCER.

2339
01:30:16,499 --> 01:30:18,134
LOOK AT CONSUMPTION.

2340
01:30:18,134 --> 01:30:22,705
IN THE 60s 52% OF MEN, 34% OF 

2341
01:30:22,705 --> 01:30:24,207
WOMEN USING TOBACCO.

2342
01:30:24,207 --> 01:30:27,210
IN 2022 IT WAS DOWN TO 14% AND 

2343
01:30:27,210 --> 01:30:28,878
11%.

2344
01:30:28,878 --> 01:30:33,716
ALCOHOL IN 2022, THE NUMBERS ARE

2345
01:30:33,716 --> 01:30:33,950
SIMILAR.

2346
01:30:33,950 --> 01:30:36,252
I LIKE THE BOTTOM ROW.

2347
01:30:36,252 --> 01:30:38,888
PHYSICIAN USE OF TOBACCO IN THE 

2348
01:30:38,888 --> 01:30:40,990
1960s WAS 50%.

2349
01:30:40,990 --> 01:30:43,025
ISN'T THAT INCREDIBLE?

2350
01:30:43,025 --> 01:30:45,495
THAT WAS DOWN TO 2% TO 7%.

2351
01:30:45,495 --> 01:30:48,197
I'M GUESSING IT IS BACK UP 

2352
01:30:48,197 --> 01:30:48,398
AGAIN.

2353
01:30:48,398 --> 01:30:50,500
SINCE COVID WE HAVE SEEN HIGH 

2354
01:30:50,500 --> 01:30:53,369
LEVELS OF STRESS IN PHYSICIANS 

2355
01:30:53,369 --> 01:30:56,105
WHICH CAN LEAD TO USE OF 

2356
01:30:56,105 --> 01:30:56,572
SUBSTANCES.

2357
01:30:56,572 --> 01:31:00,076
IN 2022 OVER 65% OF PHYSICIANS 

2358
01:31:00,076 --> 01:31:02,211
USE ALCOHOL, MORE THAN 1 OR TWO 

2359
01:31:02,211 --> 01:31:03,413
DRINKS A WEEK.

2360
01:31:03,413 --> 01:31:04,914
INTERESTING TO SEE THAT IS WHERE

2361
01:31:04,914 --> 01:31:06,983
WE ARE AND WE MIGHT BE ABLE TO 

2362
01:31:06,983 --> 01:31:08,918
LEARN LESSONS FROM THE TOBACCO 

2363
01:31:08,918 --> 01:31:11,421
STORY TO BE APPLIED TO THE 

2364
01:31:11,421 --> 01:31:13,156
ALCOHOL STORY.

2365
01:31:13,156 --> 01:31:16,092
THEY ARE TWO DIFFERENT PRODUCTS.

2366
01:31:16,092 --> 01:31:18,561
WE COULD TALK ALL DAY ABOUT THE 

2367
01:31:18,561 --> 01:31:18,961
DIFFERENCES.

2368
01:31:18,961 --> 01:31:21,664
TOBACCO IS AN ADDICTIVE 

2369
01:31:21,664 --> 01:31:21,998
SUBSTANCE.

2370
01:31:21,998 --> 01:31:23,833
WHEREAS A LARGE PROPORTION OF 

2371
01:31:23,833 --> 01:31:28,237
PEOPLE WHO DRINK ALCOHOL ARE NOT

2372
01:31:28,237 --> 01:31:28,504
ADDICTED.

2373
01:31:28,504 --> 01:31:31,741
MOST IS CONSUMED BY PEOPLE OF 

2374
01:31:31,741 --> 01:31:35,244
HIGHER SES, WHICH IS NOT TRUE OF

2375
01:31:35,244 --> 01:31:35,511
TOBACCO.

2376
01:31:35,511 --> 01:31:37,980
THOSE ARE SOME DIFFERENCES THAT 

2377
01:31:37,980 --> 01:31:39,182
WE CAN LEARN SOMETHING FROM 

2378
01:31:39,182 --> 01:31:41,150
TOBACCO, BUT WE HAVE TO BE 

2379
01:31:41,150 --> 01:31:41,384
CAREFUL.

2380
01:31:41,384 --> 01:31:45,121
IT IS INTERESTING TO TAKE A LOOK

2381
01:31:45,121 --> 01:31:47,156
AT THIS ANALYSIS USING ALL OF 

2382
01:31:47,156 --> 01:31:55,765
US, ONE OF NIH'S PEARLS ALCOHOL 

2383
01:31:55,765 --> 01:31:56,599
CONSUMPTION BETWEEN CANCER 

2384
01:31:56,599 --> 01:31:56,866
DIAGNOSIS.

2385
01:31:56,866 --> 01:31:58,434
THIS GETS AT SOME OF THE 

2386
01:31:58,434 --> 01:31:58,734
NUMBERS.

2387
01:31:58,734 --> 01:32:00,903
YOU CAN SEE THAT OF THOSE IN 

2388
01:32:00,903 --> 01:32:03,573
THIS SAMPLE, 13% EXCEEDED 

2389
01:32:03,573 --> 01:32:05,675
MODERATE DRINKING.

2390
01:32:05,675 --> 01:32:08,411
23.8% REPORTED BINGE DRINKING 

2391
01:32:08,411 --> 01:32:11,948
AND 38.3 ENGAGED IN HAZARDOUS 

2392
01:32:11,948 --> 01:32:12,215
DRINKING.

2393
01:32:12,215 --> 01:32:15,952
THAT IS ASTOUNDING AND 

2394
01:32:15,952 --> 01:32:16,252
CONCERNING.

2395
01:32:16,252 --> 01:32:19,088
WE CAN USE THESE DATA SETS TO 

2396
01:32:19,088 --> 01:32:20,089
ASSESS ASSOCIATIONS.

2397
01:32:20,089 --> 01:32:22,658
AT NCI WE HAVE A WONDERFUL 

2398
01:32:22,658 --> 01:32:23,493
PROGRAM CALLED THE CANCER 

2399
01:32:23,493 --> 01:32:25,461
PREVENTION FELLOWSHIP PROGRAM.

2400
01:32:25,461 --> 01:32:27,230
A POST DOCTORAL PROGRAM.

2401
01:32:27,230 --> 01:32:28,731
AND WE CAN RECRUIT GRADUATE 

2402
01:32:28,731 --> 01:32:30,366
STUDENTS INTO THIS PROGRAM AND 

2403
01:32:30,366 --> 01:32:32,935
HAVE THEM WORK WITH 

2404
01:32:32,935 --> 01:32:33,870
INVESTIGATORS AT NCI.

2405
01:32:33,870 --> 01:32:37,273
AND SO WE'VE GOT A STABLE OF 

2406
01:32:37,273 --> 01:32:38,207
WONDERFUL CANCER PREVENTION 

2407
01:32:38,207 --> 01:32:40,209
FELLOWS RIGHT NOW WORKING ON 

2408
01:32:40,209 --> 01:32:41,377
WARNING LABEL RESEARCH REGARDING

2409
01:32:41,377 --> 01:32:42,478
ALCOHOL AND CANCER.

2410
01:32:42,478 --> 01:32:44,413
DOING SOME REALLY TERRIFIC WORK 

2411
01:32:44,413 --> 01:32:45,948
IN WHICH THEY ARE COLLECTING 

2412
01:32:45,948 --> 01:32:47,817
DATA ON WHAT KINDS OF MESSAGES 

2413
01:32:47,817 --> 01:32:49,252
ARE MOST IMPACTFUL.

2414
01:32:49,252 --> 01:32:51,420
THIS SLIDE GIVES YOU A SENSE OF 

2415
01:32:51,420 --> 01:32:55,291
THE KINDS OF THINGS THEY ARE 

2416
01:32:55,291 --> 01:32:55,791
LOOKING AT.

2417
01:32:55,791 --> 01:33:00,062
FOR EXAMPLE, WHAT ABOUT THE 

2418
01:33:00,062 --> 01:33:01,030
CERTAINTY IN THE MESSAGE.

2419
01:33:01,030 --> 01:33:03,266
SHOULD YOU SAY ALCOHOL CAUSES 

2420
01:33:03,266 --> 01:33:05,601
CANCER OR MAY CAUSE CANCER?

2421
01:33:05,601 --> 01:33:07,370
WE HAVE DONE PILOT WORK.

2422
01:33:07,370 --> 01:33:09,372
WHEN PEOPLE ARE TOLD ALCOHOL 

2423
01:33:09,372 --> 01:33:11,874
CAUSES CANCER NUMBER ONE THEY 

2424
01:33:11,874 --> 01:33:18,514
ASSUME THAT MEANS THEY ARE GOING

2425
01:33:18,514 --> 01:33:19,715
TO GET CANCER WHEN THEY DRINK 

2426
01:33:19,715 --> 01:33:20,049
ALCOHOL.

2427
01:33:20,049 --> 01:33:21,884
THAT IS NOT WHAT WE MEAN, BUT 

2428
01:33:21,884 --> 01:33:23,352
OFTEN THE WAY IT IS INTERPRETED.

2429
01:33:23,352 --> 01:33:25,288
THE SECOND THING IS WHEN PEOPLE 

2430
01:33:25,288 --> 01:33:26,789
ARE TOLD ALCOHOL CAUSES CANCER, 

2431
01:33:26,789 --> 01:33:29,859
THEY EXPERIENCE THE 

2432
01:33:29,859 --> 01:33:32,495
PSYCHOLOGICAL TERM REACTANCE, 

2433
01:33:32,495 --> 01:33:34,263
BELIEVING THEIR CONTROL IS TAKEN

2434
01:33:34,263 --> 01:33:36,299
AWAY AND TRYING TO BE 

2435
01:33:36,299 --> 01:33:36,599
MANIPULATED.

2436
01:33:36,599 --> 01:33:37,967
THAT IS PROBLEMATIC.

2437
01:33:37,967 --> 01:33:40,703
WE HAVE THE W.H.O. SAYING 

2438
01:33:40,703 --> 01:33:41,938
ALCOHOL CAUSES CANCER AND SAYING

2439
01:33:41,938 --> 01:33:43,706
THERE IS NO SAFE LEVEL OF 

2440
01:33:43,706 --> 01:33:44,040
ALCOHOL.

2441
01:33:44,040 --> 01:33:47,877
THAT TURNS OUT TO BE A BIT OF AN

2442
01:33:47,877 --> 01:33:48,077
ISSUE.

2443
01:33:48,077 --> 01:33:50,780
WHEN PEOPLE SAY THERE IS NO SAFE

2444
01:33:50,780 --> 01:33:51,547
LEVEL YOUR CREDIBILITY GOES 

2445
01:33:51,547 --> 01:33:51,981
DOWN.

2446
01:33:51,981 --> 01:33:53,983
IT SOUNDS LIKE ONE DROP OF 

2447
01:33:53,983 --> 01:33:55,017
ALCOHOL IS GOING TO CAUSE YOU TO

2448
01:33:55,017 --> 01:33:55,851
GET CANCER.

2449
01:33:55,851 --> 01:34:00,856
THAT IS NOT GOING TO SELL VERY 

2450
01:34:00,856 --> 01:34:01,057
WELL.

2451
01:34:01,057 --> 01:34:03,759
IT IS NOT CLEAR THIS NO SAFE 

2452
01:34:03,759 --> 01:34:05,227
LEVEL W.H.O. LANGUAGE IS GOING 

2453
01:34:05,227 --> 01:34:06,796
TO WORK ON A WARNING LEVEL.

2454
01:34:06,796 --> 01:34:10,132
THESE ARE THINGS WE HAVE BEEN 

2455
01:34:10,132 --> 01:34:11,801
WORKING ON OUR FELLOWS IN 

2456
01:34:11,801 --> 01:34:13,803
CONCERT WITH OUR STAFF.

2457
01:34:13,803 --> 01:34:16,205
THE PREVIOUS SURGEON GENERAL 

2458
01:34:16,205 --> 01:34:18,307
RECOMMENDED WE HAVE WARNING 

2459
01:34:18,307 --> 01:34:21,010
LABELS ON ALCOHOLIC BEVERAGES 

2460
01:34:21,010 --> 01:34:22,011
LINKING ALCOHOL TO CANCER.

2461
01:34:22,011 --> 01:34:24,113
WHAT SHOULD BE ON THOSE LABELS?

2462
01:34:24,113 --> 01:34:25,414
WE DON'T KNOW.

2463
01:34:25,414 --> 01:34:27,216
WE DON'T HAVE ENOUGH DATA.

2464
01:34:27,216 --> 01:34:29,485
WE CAN LEARN FROM TOBACCO, BUT 

2465
01:34:29,485 --> 01:34:34,590
WE CAN ONLY LEARN SO MUCH.

2466
01:34:34,590 --> 01:34:36,592
HERE ARE FINDINGS FROM STUDIES 

2467
01:34:36,592 --> 01:34:37,793
WE HAVE DONE SO FAR.

2468
01:34:37,793 --> 01:34:41,263
WHEN YOU SAY DRINKING ALCOHOL 

2469
01:34:41,263 --> 01:34:45,401
CAUSES CANCER, IT INCREASING 

2470
01:34:45,401 --> 01:34:50,172
KNOWLEDGE OF RISK.

2471
01:34:50,172 --> 01:34:51,707
IT DECREASES.

2472
01:34:51,707 --> 01:34:53,776
SHOULD YOU SAY ALCOHOL CAUSES 

2473
01:34:53,776 --> 01:34:55,911
CANCER OR COLON CANCER OR BREAST

2474
01:34:55,911 --> 01:34:56,379
CANCER?

2475
01:34:56,379 --> 01:34:59,415
BOTH OF TRUE AND MIGHT BE MORE 

2476
01:34:59,415 --> 01:35:00,216
IMPACTFUL.

2477
01:35:00,216 --> 01:35:05,221
THOSE MESSAGES DO INCREASE 

2478
01:35:05,221 --> 01:35:06,822
CREDIBILITY.

2479
01:35:06,822 --> 01:35:10,559
IF YOU LOOK AT SOME OF THE 

2480
01:35:10,559 --> 01:35:13,062
LABELS CANADA, IRELAND AND SOUTH

2481
01:35:13,062 --> 01:35:15,364
KOREA ARE USING THEY ARE 

2482
01:35:15,364 --> 01:35:16,565
FOCUSING ON SPECIFIC CANCERS 

2483
01:35:16,565 --> 01:35:20,469
LIKE COLON AND BREAST CANCER.

2484
01:35:20,469 --> 01:35:23,305
ALASKA HAS JUST APPROVED A NEW 

2485
01:35:23,305 --> 01:35:25,341
WARNING LABEL THAT FOCUSES ON 

2486
01:35:25,341 --> 01:35:27,076
ALCOHOL AND CANCER AND THAT WILL

2487
01:35:27,076 --> 01:35:28,044
GO INTO EFFECT SOON.

2488
01:35:28,044 --> 01:35:29,378
IT WILL BE INTERESTING TO SEE 

2489
01:35:29,378 --> 01:35:32,181
WHAT THEY DO, THE IMPACT OF WHAT

2490
01:35:32,181 --> 01:35:34,150
THAT IS AND THEY DO, IN FACT, 

2491
01:35:34,150 --> 01:35:35,418
FOCUS ON SPECIFIC CANCERS.

2492
01:35:35,418 --> 01:35:36,352
WHAT ABOUT THE SOURCE?

2493
01:35:36,352 --> 01:35:38,721
SHOULD YOU SAY IT IS THE SURGEON

2494
01:35:38,721 --> 01:35:39,822
GENERAL'S WARNING?

2495
01:35:39,822 --> 01:35:41,057
A GOVERNMENT WORNING?

2496
01:35:41,057 --> 01:35:42,925
NO, BY THE WAY, THAT DOESN'T 

2497
01:35:42,925 --> 01:35:43,459
WORK.

2498
01:35:43,459 --> 01:35:47,029
OR SHOULD IT BE DON'T INDICATE 

2499
01:35:47,029 --> 01:35:47,997
WHERE THE SOURCE IS?

2500
01:35:47,997 --> 01:35:49,665
PEOPLE DO TRUST THE SURGEON 

2501
01:35:49,665 --> 01:35:49,899
GENERAL.

2502
01:35:49,899 --> 01:35:51,734
SO THE SURGEON GENERAL'S WARNING

2503
01:35:51,734 --> 01:35:53,703
IS MORE IMPACTFUL.

2504
01:35:53,703 --> 01:35:54,870
THE TYPE OF MESSAGING.

2505
01:35:54,870 --> 01:35:58,174
I MENTIONED NO SAFE LEVEL OF 

2506
01:35:58,174 --> 01:35:58,974
ALCOHOL CONSUMPTION DOESN'T GO 

2507
01:35:58,974 --> 01:36:00,743
OVER VERY WELL IN OUR 

2508
01:36:00,743 --> 01:36:02,244
POPULATIONS IN WHICH WE ARE 

2509
01:36:02,244 --> 01:36:03,079
COLLECTING DATA.

2510
01:36:03,079 --> 01:36:05,781
IT INCREASING PERCEIVED ALCOHOL 

2511
01:36:05,781 --> 01:36:08,117
RELATED CANCER RISK BUT 

2512
01:36:08,117 --> 01:36:08,818
DECREASES CERTAINTY ABOUT 

2513
01:36:08,818 --> 01:36:11,220
ALCOHOL RELATED CANCER RISK AND 

2514
01:36:11,220 --> 01:36:11,854
MESSAGE BELIEVABILITY.

2515
01:36:11,854 --> 01:36:13,222
SO YOU HAVE THIS SORT OF TENSION

2516
01:36:13,222 --> 01:36:15,624
HERE AND HOW DO YOU RESOLVE THAT

2517
01:36:15,624 --> 01:36:15,858
TENSION?

2518
01:36:15,858 --> 01:36:17,760
WHAT LABELS SHOULD BE USED?

2519
01:36:17,760 --> 01:36:20,896
WE HAVE THIS WHOLE LITERATURE IN

2520
01:36:20,896 --> 01:36:23,032
TOBACCO OF WHAT LABELS WORK 

2521
01:36:23,032 --> 01:36:23,365
THERE.

2522
01:36:23,365 --> 01:36:25,835
THOSE LABELS GET LITIGATED TO 

2523
01:36:25,835 --> 01:36:29,905
THE POINT IT IS DIFFICULT TO USE

2524
01:36:29,905 --> 01:36:33,409
LABELS WE KNOW WORK IN 

2525
01:36:33,409 --> 01:36:34,643
POPULATIONS BUT AREN'T GOING TO 

2526
01:36:34,643 --> 01:36:35,845
SURVIVE LITIGATION BECAUSE THEY 

2527
01:36:35,845 --> 01:36:38,214
ARE VIEWED AS VIOLATIONS OF 

2528
01:36:38,214 --> 01:36:39,248
FIRST AMENDMENT.

2529
01:36:39,248 --> 01:36:41,083
LOTS TO DO IN THIS SPACE.

2530
01:36:41,083 --> 01:36:43,285
I WANT TO HIGHLIGHT THESE 

2531
01:36:43,285 --> 01:36:44,653
RECENTLY RELEASED DOCUMENTS.

2532
01:36:44,653 --> 01:36:47,957
I HAVE A WHOLE GROUP AT NCI HOW 

2533
01:36:47,957 --> 01:36:50,025
PEOPLE RESPOND TO CONFLICTING 

2534
01:36:50,025 --> 01:36:51,660
SCIENTIFIC MESSAGING.

2535
01:36:51,660 --> 01:36:53,229
THIS IS IT IN THE WILD.

2536
01:36:53,229 --> 01:36:54,897
WHAT HAPPENS WHEN YOU HAVE TWO 

2537
01:36:54,897 --> 01:36:57,500
BIG REPORTS COME OUT AND THEY 

2538
01:36:57,500 --> 01:36:57,967
CONFLICT?

2539
01:36:57,967 --> 01:36:58,901
THIS NATIONAL ACADEMIES OF 

2540
01:36:58,901 --> 01:37:01,403
SCIENCE, ENGINEERING AND 

2541
01:37:01,403 --> 01:37:03,806
MEDICINE CAME OUT WITH A REVIEW 

2542
01:37:03,806 --> 01:37:04,940
OF ED ON ALCOHOL AND HEALTH IN 

2543
01:37:04,940 --> 01:37:05,741
THE FALL.

2544
01:37:05,741 --> 01:37:07,743
THEY TENDED TO -- THAT REPORT 

2545
01:37:07,743 --> 01:37:09,779
FOCUSED ON A MUCH SMALLER SET OF

2546
01:37:09,779 --> 01:37:13,015
STUDIES AND THE CONCLUSIONS WERE

2547
01:37:13,015 --> 01:37:14,984
THAT THE LINK BETWEEN ALCOHOL 

2548
01:37:14,984 --> 01:37:17,253
AND CANCER WERE MORE MUTED THAN 

2549
01:37:17,253 --> 01:37:18,254
HAD BEEN THOUGHT.

2550
01:37:18,254 --> 01:37:20,189
THE LINK WITH BREAST CANCER WAS 

2551
01:37:20,189 --> 01:37:25,761
STILL THERE, BUT NOT SO MUCH FOR

2552
01:37:25,761 --> 01:37:25,961
THOSE.

2553
01:37:25,961 --> 01:37:29,265
THE ICCPUD STUDY, A GROUP RAN 

2554
01:37:29,265 --> 01:37:32,134
OUT OF SAMHSA.

2555
01:37:32,134 --> 01:37:34,904
THEY CAME OUT OF A STUDY MUST 

2556
01:37:34,904 --> 01:37:36,505
MORE WIDE RANGING AND THEIR 

2557
01:37:36,505 --> 01:37:37,339
CONCLUSIONS ARE MORE CONSISTENT 

2558
01:37:37,339 --> 01:37:38,407
WITH THE LITERATURE THAT WE HAVE

2559
01:37:38,407 --> 01:37:42,578
BEEN LOOKING AT AND WE'VE BEEN 

2560
01:37:42,578 --> 01:37:43,579
WORKING WITH.

2561
01:37:43,579 --> 01:37:44,880
SUGGESTS THAT THE LINK TO 

2562
01:37:44,880 --> 01:37:47,449
MULTIPLE CANCERS IS SIGNIFICANT 

2563
01:37:47,449 --> 01:37:48,584
AS WELL AS OTHER HEALTH ISSUES 

2564
01:37:48,584 --> 01:37:49,718
MANY OF WHICH GEORGE MENTIONED 

2565
01:37:49,718 --> 01:37:50,653
IN HIS PRESENTATION.

2566
01:37:50,653 --> 01:37:52,288
RIGHT IN THE MIDDLE OF THE SLIDE

2567
01:37:52,288 --> 01:37:54,056
YOU HAVE THE SURGEON GENERAL'S 

2568
01:37:54,056 --> 01:37:55,124
REPORT ON ALCOHOL AND CANCER 

2569
01:37:55,124 --> 01:37:55,424
RISK.

2570
01:37:55,424 --> 01:37:57,726
THIS WAS NOT A REVIEW, PER SE, 

2571
01:37:57,726 --> 01:38:00,563
IT WAS AN ADVISE I HAVE.

2572
01:38:00,563 --> 01:38:05,367
IT WAS THE LAST VIVEK MURTHY 

2573
01:38:05,367 --> 01:38:07,102
CAME OUT AS SURGEON GENERAL.

2574
01:38:07,102 --> 01:38:11,073
IT SUGGESTED A NUMBER OF 

2575
01:38:11,073 --> 01:38:12,608
DIFFERENT THINGS SO THIS WAS 

2576
01:38:12,608 --> 01:38:14,376
RELEASED IN 2025.

2577
01:38:14,376 --> 01:38:17,980
EXPERT INPUT WAS RECEIVED FROM 

2578
01:38:17,980 --> 01:38:18,614
DEPARTMENT OF HEALTH AND HUMAN 

2579
01:38:18,614 --> 01:38:20,182
SERVICES STAFF, INCLUDING NCI 

2580
01:38:20,182 --> 01:38:21,784
STAFF FROM OUR DIVISION.

2581
01:38:21,784 --> 01:38:27,122
THAT WAS COORDINATED BY DAVID 

2582
01:38:27,122 --> 01:38:28,691
BARRIGAN, MY COLLEAGUE AT NCI.

2583
01:38:28,691 --> 01:38:29,925
THERE WAS A RECENT PRESENTATION 

2584
01:38:29,925 --> 01:38:31,160
AT THE NATIONAL ACADEMIES 

2585
01:38:31,160 --> 01:38:31,427
WORKSHOP.

2586
01:38:31,427 --> 01:38:32,862
A DIFFERENT PART OF THE NATIONAL

2587
01:38:32,862 --> 01:38:34,196
ACADEMIES FROM THE ONE THAT CAME

2588
01:38:34,196 --> 01:38:35,764
OUT WITH THE CON FLIBLGTING 

2589
01:38:35,764 --> 01:38:35,998
REPORT.

2590
01:38:35,998 --> 01:38:38,167
HERE ARE SOME OF THE CONCLUSIONS

2591
01:38:38,167 --> 01:38:40,202
OF THAT SURGEON GENERAL'S 

2592
01:38:40,202 --> 01:38:40,936
ADVISORY.

2593
01:38:40,936 --> 01:38:41,737
PRIMARILY WHAT THE SURGEON 

2594
01:38:41,737 --> 01:38:44,974
GENERAL SAYS WE NEED TO UPDATE 

2595
01:38:44,974 --> 01:38:45,774
WARNING LABELS.

2596
01:38:45,774 --> 01:38:48,711
THAT IS WHY I FOCUSED SO MUCH OF

2597
01:38:48,711 --> 01:38:50,980
THE WORK WE ARE DOING ON WARNING

2598
01:38:50,980 --> 01:38:51,247
LABELS.

2599
01:38:51,247 --> 01:38:54,183
THIS IS NOT PUBLISHED YET.

2600
01:38:54,183 --> 01:38:58,020
WE HAVE A FELLOW WORKING ON A 

2601
01:38:58,020 --> 01:39:01,056
PROJECT, USING HINTS DATA 60% TO

2602
01:39:01,056 --> 01:39:04,026
70% OF THE POPULATION IS 

2603
01:39:04,026 --> 01:39:05,928
SUPPORTIVE OF THESE WARNING 

2604
01:39:05,928 --> 01:39:06,161
LABELS.

2605
01:39:06,161 --> 01:39:08,364
THAT IS USEFUL.

2606
01:39:08,364 --> 01:39:09,965
IF WE PUT SOMETHING OUT AND 

2607
01:39:09,965 --> 01:39:12,167
PEOPLE THROW IT AWAY AND SAY, 

2608
01:39:12,167 --> 01:39:14,169
NO, I DON'T WANT THAT.

2609
01:39:14,169 --> 01:39:15,971
THAT IS A PROBLEM.

2610
01:39:15,971 --> 01:39:22,278
SO HAVING THAT BENEFICENT LABELS

2611
01:39:22,278 --> 01:39:25,714
IS A GOOD THING.

2612
01:39:25,714 --> 01:39:29,618
REASSESS RECOMMENDS LIMITS FOR 

2613
01:39:29,618 --> 01:39:31,420
ALCOHOL CONSUMPTION AND WE KNOW 

2614
01:39:31,420 --> 01:39:33,689
FROM OUR REVIEW OF CANCER 

2615
01:39:33,689 --> 01:39:36,125
CENTERS THERE IS NOT A LOT OF 

2616
01:39:36,125 --> 01:39:37,293
ATTENTION BETWEEN THE LINK OF 

2617
01:39:37,293 --> 01:39:38,327
ALCOHOL A CANCER.

2618
01:39:38,327 --> 01:39:40,362
THEY ARE NOT EQUIPPED.

2619
01:39:40,362 --> 01:39:45,734
WE HAVE SEEN AN INCREASE IN 

2620
01:39:45,734 --> 01:39:48,137
TOBACCO AND LESS SO IN ALCOHOL.

2621
01:39:48,137 --> 01:39:50,272
WE HAVE A GROUP LOOKING AT 

2622
01:39:50,272 --> 01:39:52,041
MATERIALS PRODUCED BY CANCER 

2623
01:39:52,041 --> 01:39:53,909
CENTERS TO SEE WHERE WE ARE.

2624
01:39:53,909 --> 01:39:55,911
SOME CANCER CENTERS ARE FURTHER 

2625
01:39:55,911 --> 01:39:56,111
ALONG.

2626
01:39:56,111 --> 01:39:57,913
YOU CAN'T FAULT THEM BECAUSE I 

2627
01:39:57,913 --> 01:39:59,915
SAID IN RESPONSE TO ONE OF THE 

2628
01:39:59,915 --> 01:40:01,717
QUESTIONS TO GEORGE, WE DON'T 

2629
01:40:01,717 --> 01:40:04,086
HAVE TRIED AND TRUE MATERIALS, 

2630
01:40:04,086 --> 01:40:05,054
WELL-TESTED MATERIALS THAT CAN 

2631
01:40:05,054 --> 01:40:06,555
BE USED AND THERE IS A GREAT 

2632
01:40:06,555 --> 01:40:08,791
NEED FOR THAT IN THE LITERATURE.

2633
01:40:08,791 --> 01:40:10,726
I DO WANT TO HIGHLIGHT THESE 

2634
01:40:10,726 --> 01:40:11,827
REPORTS I JUST MENTIONED ARE 

2635
01:40:11,827 --> 01:40:15,097
GOING TO BE USED IN DEVELOPING 

2636
01:40:15,097 --> 01:40:18,233
THE 2025 DIETARY GUIDELINES.

2637
01:40:18,233 --> 01:40:22,471
ALL OF THESE IMPORTANTS ARE 

2638
01:40:22,471 --> 01:40:23,238
IMPORTANT.

2639
01:40:23,238 --> 01:40:27,343
THERE HAVE BEEN CRITIQUES OF THE

2640
01:40:27,343 --> 01:40:31,747
NATIONAL ACADEMIES AND ICCPUD 

2641
01:40:31,747 --> 01:40:31,981
REPORTS.

2642
01:40:31,981 --> 01:40:33,716
WE HOPE TO SEE THE GUIDELINES 

2643
01:40:33,716 --> 01:40:34,516
COME OUT THIS YEAR.

2644
01:40:34,516 --> 01:40:36,385
IT WILL BE INTERESTING TO SEE 

2645
01:40:36,385 --> 01:40:37,786
WHERE ALCOHOL GOES.

2646
01:40:37,786 --> 01:40:40,189
IN GENERAL WE HAVE NOT SEEN 

2647
01:40:40,189 --> 01:40:43,659
CHANGES IN THE DIETARY 

2648
01:40:43,659 --> 01:40:48,297
GUIDELINES FOR MANY, MANY YEARS.

2649
01:40:48,297 --> 01:40:50,299
I DON'T KNOW IF THIS WILL IMPACT

2650
01:40:50,299 --> 01:40:50,532
THAT.

2651
01:40:50,532 --> 01:40:52,568
I WILL WRAP UP SAYS WE HAVE 

2652
01:40:52,568 --> 01:40:54,269
RESOURCES WE HOPE YOU WILL USE, 

2653
01:40:54,269 --> 01:40:57,773
THE NATIONAL TREND SURVEY.

2654
01:40:57,773 --> 01:40:59,174
SMOKEFREE.GOV, WHICH IS A 

2655
01:40:59,174 --> 01:41:01,010
TERRIFIC TOOL FOR SMOKERS TO USE

2656
01:41:01,010 --> 01:41:04,646
FOR CESSATION PUMPS AND SEPARATE

2657
01:41:04,646 --> 01:41:06,815
SMOKEFREE.GOV MODULES FOR 

2658
01:41:06,815 --> 01:41:07,449
DIFFERENT POPULATIONS AND FOR 

2659
01:41:07,449 --> 01:41:09,585
EXAMPLE, FOR TEENS.

2660
01:41:09,585 --> 01:41:11,320
WE HAVE THE TOBACCO USE 

2661
01:41:11,320 --> 01:41:12,955
SUPPLEMENT TO THE CURRENT 

2662
01:41:12,955 --> 01:41:14,289
POPULATION SUMMARY.

2663
01:41:14,289 --> 01:41:15,691
THE CLASSIFICATION OF LAWS 

2664
01:41:15,691 --> 01:41:19,628
ASSOCIATED WITH SCHOOL STUDENTS 

2665
01:41:19,628 --> 01:41:21,897
WHICH TRACKS POLICIES RELATED 

2666
01:41:21,897 --> 01:41:25,367
OBESITY OUTCOMES, PHYSICAL 

2667
01:41:25,367 --> 01:41:28,804
ACTIVITY GUIDELINES AND VENDING 

2668
01:41:28,804 --> 01:41:29,071
MACHINES.

2669
01:41:29,071 --> 01:41:32,074
AUTOMATED SELF-ADMINISTERED 

2670
01:41:32,074 --> 01:41:35,244
24-HOUR DIETARY ASSESSMENT TOOL,

2671
01:41:35,244 --> 01:41:38,380
ASA24 IS A GREAT WAY TO TRACK 

2672
01:41:38,380 --> 01:41:38,647
BEHAVIOR.

2673
01:41:38,647 --> 01:41:41,183
WE HAVE THE ACTS 24 LOOKING AT 

2674
01:41:41,183 --> 01:41:43,952
ACTS COMPLETED OVER TIME IN 24 

2675
01:41:43,952 --> 01:41:44,153
HOURS.

2676
01:41:44,153 --> 01:41:47,289
WE ALL KNOW, THOSE OF US IN 

2677
01:41:47,289 --> 01:41:48,190
BEHAVIORAL SCIENCE, JUST ASKING 

2678
01:41:48,190 --> 01:41:49,525
PEOPLE WHAT THEY DID LAST YEAR 

2679
01:41:49,525 --> 01:41:51,226
IS NOT GOING TO GET YOU VERY 

2680
01:41:51,226 --> 01:41:53,529
MUCH OR EVEN A MONTH AGO, BUT 

2681
01:41:53,529 --> 01:41:55,731
TRYING TO TRACK PEOPLE ON A 

2682
01:41:55,731 --> 01:41:57,833
DAILY BASIS, HOURLY BASIS, GIVES

2683
01:41:57,833 --> 01:41:59,668
YOU A MUCH BETTER WINDOW AND WE 

2684
01:41:59,668 --> 01:42:01,170
HAVE SMART PHONES NOW THAT MAKE 

2685
01:42:01,170 --> 01:42:02,438
THAT EASIER.

2686
01:42:02,438 --> 01:42:05,140
JUST AS AN ASIDE, BY THE WAY, WE

2687
01:42:05,140 --> 01:42:06,708
HAVE ALL THESE THEORYS DEVELOPED

2688
01:42:06,708 --> 01:42:09,611
IN THE 60s TO UNDERSTAND AND 

2689
01:42:09,611 --> 01:42:12,581
PREDICT AND INTERVENE ON HEALTH 

2690
01:42:12,581 --> 01:42:14,016
BEHAVIOR BASED ON PAPER AND 

2691
01:42:14,016 --> 01:42:16,218
PENCIL SURVEYS IN WAYS WE WOULD 

2692
01:42:16,218 --> 01:42:17,920
LAUGH OUT NOW.

2693
01:42:17,920 --> 01:42:20,255
WE STILL USE THOSE SAME THEORYS 

2694
01:42:20,255 --> 01:42:24,726
AND WE DON'T HAVE NEW THEORYS 

2695
01:42:24,726 --> 01:42:28,097
THAT USE INTENSE LONGITUDINAL 

2696
01:42:28,097 --> 01:42:30,365
DATA WE COULD TRACK USING SMART 

2697
01:42:30,365 --> 01:42:30,666
PHONES.

2698
01:42:30,666 --> 01:42:34,570
WE HAVE A LIBRARY OF WEBINARS 

2699
01:42:34,570 --> 01:42:36,038
ABOUT ALCOHOL AND TOBACCO.

2700
01:42:36,038 --> 01:42:37,539
YOU CAN GO TO THAT LINK AND SEE 

2701
01:42:37,539 --> 01:42:38,373
WHAT WE HAVE THERE.

2702
01:42:38,373 --> 01:42:40,676
YOU CAN GO TO OUR WEBSITE AND 

2703
01:42:40,676 --> 01:42:42,878
NEWSLETTER FOR ADDITIONAL 

2704
01:42:42,878 --> 01:42:43,979
INFORMATION AND I'M ALWAYS HAPPY

2705
01:42:43,979 --> 01:42:45,948
TO TAKE QUESTIONS OR TRIAGE YOUR

2706
01:42:45,948 --> 01:42:48,183
QUESTIONS TO OTHERS WHO HAVE 

2707
01:42:48,183 --> 01:42:49,118
MORE EXPERTISE ON MY TEAM.

2708
01:42:49,118 --> 01:42:50,419
THAT IT IS FOR ME.

2709
01:42:50,419 --> 01:42:50,953
THANK YOU.

2710
01:42:50,953 --> 01:42:59,027
I'M HAPPY TO TAKE QUESTIONS.

2711
01:42:59,027 --> 01:43:00,996
>> BILL, LET'S SEE IF
THERE ARE 

2712
01:43:00,996 --> 01:43:03,065
ANY QUESTIONS FROM THE COUNCIL.

2713
01:43:03,065 --> 01:43:04,700
WHILE WE ARE WAITING, I HAVE A 

2714
01:43:04,700 --> 01:43:05,367
QUICK QUESTION.

2715
01:43:05,367 --> 01:43:06,168
>> YES.

2716
01:43:06,168 --> 01:43:09,037
>> WHAT ABOUT CANNABIS AND

2717
01:43:09,037 --> 01:43:09,404
CANCER?

2718
01:43:09,404 --> 01:43:12,174
IS THERE ANY EVIDENCE AND ARE 

2719
01:43:12,174 --> 01:43:15,744
YOU GUYS GOING TO BE -- IS THE 

2720
01:43:15,744 --> 01:43:16,845
CANCER INSTITUTE GOING TO BE 

2721
01:43:16,845 --> 01:43:18,180
LOOKING INTO THIS?

2722
01:43:18,180 --> 01:43:19,815
>> YEAH.

2723
01:43:19,815 --> 01:43:21,650
ABSOLUTELY.

2724
01:43:21,650 --> 01:43:24,219
NO, WE DON'T HAVE ENOUGH 

2725
01:43:24,219 --> 01:43:25,420
EVIDENCE YET.

2726
01:43:25,420 --> 01:43:27,523
THERE WILL BE SOME FOR 

2727
01:43:27,523 --> 01:43:29,224
COMBUSTIBLE CANNABIS.

2728
01:43:29,224 --> 01:43:32,094
WITH REGARD TO EDIBLES AND OTHER

2729
01:43:32,094 --> 01:43:34,463
MODES, MUCH LESS CLEAR.

2730
01:43:34,463 --> 01:43:36,365
WE NEED MUCH MORE DATA.

2731
01:43:36,365 --> 01:43:40,369
WE HAVE A DIVISION OF CANCER 

2732
01:43:40,369 --> 01:43:40,969
EPIDEMIOLOGY AND GENETICS, 

2733
01:43:40,969 --> 01:43:43,105
INTRAMURAL PART OF NCI AND THEY 

2734
01:43:43,105 --> 01:43:44,873
COLLECT THAT EPIDEMIOLOGY DATA.

2735
01:43:44,873 --> 01:43:48,177
WE HAVE COHORTS WE FUND 

2736
01:43:48,177 --> 01:43:49,845
COLLECTING THESE DATA MORE AND 

2737
01:43:49,845 --> 01:43:50,045
MORE.

2738
01:43:50,045 --> 01:43:51,446
IT IS A WHOLE NEW WORLD.

2739
01:43:51,446 --> 01:43:53,882
IT IS A WILD WEST WITH CANNABIS 

2740
01:43:53,882 --> 01:43:55,217
AND WITH ALCOHOL TO SOME DEGREE 

2741
01:43:55,217 --> 01:43:56,185
AS WELL.

2742
01:43:56,185 --> 01:44:00,122
>> IT WAS A GREAT TALK.

2743
01:44:00,122 --> 01:44:01,223
SO QUESTIONS FROM COUNCIL?

2744
01:44:01,223 --> 01:44:01,857
>> YES.

2745
01:44:01,857 --> 01:44:06,862
THERE IS A QUESTION FROM KAREN 

2746
01:44:06,862 --> 01:44:07,095
EMMONDS.

2747
01:44:07,095 --> 01:44:08,297
>> HEY, KAREN.

2748
01:44:08,297 --> 01:44:09,731
>> HEY, BILL.

2749
01:44:09,731 --> 01:44:11,567
THANK YOU SO MUCH FOR A GREAT 

2750
01:44:11,567 --> 01:44:12,100
PRESENTATION.

2751
01:44:12,100 --> 01:44:15,003
ONE OF THE THINGS NCI AND YOUR 

2752
01:44:15,003 --> 01:44:20,442
DIVISION HAS DONE SO WELL -- 

2753
01:44:20,442 --> 01:44:23,378
>> GO AHEAD.

2754
01:44:23,378 --> 01:44:29,484
>> I'M HEARING SOME
BACKGROUND.

2755
01:44:29,484 --> 01:44:32,321
SO THE SURVEILLANCE ASPECT -- 

2756
01:44:32,321 --> 01:44:37,926
I'M SORRY.

2757
01:44:37,926 --> 01:44:39,294
>> COULD SOMEONE MUTE
PLEASE.

2758
01:44:39,294 --> 01:44:41,530
>> I THINK WE GOT IT.

2759
01:44:41,530 --> 01:44:43,332
SO SURVEILLANCE YOU HAVE DONE IS

2760
01:44:43,332 --> 01:44:45,133
REALLY ELEGANT AND SO, SO 

2761
01:44:45,133 --> 01:44:46,368
IMPORTANT ESPECIALLY WITH TOPICS

2762
01:44:46,368 --> 01:44:48,203
WHERE THERE IS AN INDUSTRY THAT 

2763
01:44:48,203 --> 01:44:49,805
IS CONSTANTLY TRYING TO SHIFT 

2764
01:44:49,805 --> 01:44:51,306
THINGS AND CHANGE THE DYNAMIC.

2765
01:44:51,306 --> 01:44:52,474
IT IS SO IMPORTANT.

2766
01:44:52,474 --> 01:44:57,446
THERE IS A RUMOR OUT IN THE 

2767
01:44:57,446 --> 01:44:59,114
WORLD THAT N HAYNES IS GOING 

2768
01:44:59,114 --> 01:44:59,548
AWAY.

2769
01:44:59,548 --> 01:45:00,983
WIPED IN JUNE AND PROBABLY NOT 

2770
01:45:00,983 --> 01:45:02,884
GOING TO BE REUPPED AND THAT 

2771
01:45:02,884 --> 01:45:04,786
SCARES LOOT OF US IN THE SIGN 

2772
01:45:04,786 --> 01:45:05,621
TICHIC WORLD.

2773
01:45:05,621 --> 01:45:08,190
THE POINT IS I'M WONDERING WHAT 

2774
01:45:08,190 --> 01:45:10,058
THAT MEANS FOR YOUR EFFORTS IN 

2775
01:45:10,058 --> 01:45:10,692
SURVEILLANCE?

2776
01:45:10,692 --> 01:45:12,594
IF SOME OF THESE REALLY 

2777
01:45:12,594 --> 01:45:13,362
IMPORTANT LARGE SCALE RESOURCES 

2778
01:45:13,362 --> 01:45:15,964
WE HAVE BEEN DEPENDING ON TO 

2779
01:45:15,964 --> 01:45:16,765
HELP US UNDERSTAND THESE ISSUES 

2780
01:45:16,765 --> 01:45:19,001
ARE GOING AWAY IN ONE PLACE, 

2781
01:45:19,001 --> 01:45:22,537
WHAT CAN WE DO TO HELP YOU 

2782
01:45:22,537 --> 01:45:24,206
PROTECT THE SURVEILLANCE GOING 

2783
01:45:24,206 --> 01:45:26,074
ON IN YOUR DIVISION AND, YEAH, 

2784
01:45:26,074 --> 01:45:27,976
HOW DO WE PROTECT IT?

2785
01:45:27,976 --> 01:45:28,877
>> THANK YOU, KAREN.

2786
01:45:28,877 --> 01:45:29,311
GREAT QUESTION.

2787
01:45:29,311 --> 01:45:31,446
OF COURSE, ONE OF THE BIGGEST 

2788
01:45:31,446 --> 01:45:32,547
TOOLS AND I DIDN'T MENTION THIS 

2789
01:45:32,547 --> 01:45:35,717
IN MY PRESENTATION, IT IS AN 

2790
01:45:35,717 --> 01:45:37,653
IMPORTANT TOOL, SURVEILLANCE 

2791
01:45:37,653 --> 01:45:38,687
EPIDEMIOLOGY PROGRAM THAT TRACKS

2792
01:45:38,687 --> 01:45:40,122
CANCER OVER TIME.

2793
01:45:40,122 --> 01:45:41,790
WE JUST PRODUCED AN ANNUAL 

2794
01:45:41,790 --> 01:45:43,292
REPORT TO THE NATION WHICH WE DO

2795
01:45:43,292 --> 01:45:44,960
IN CONSULTATION WITH THE 

2796
01:45:44,960 --> 01:45:45,994
AMERICAN CANCER SOCIETY AND 

2797
01:45:45,994 --> 01:45:46,928
THOSE ARE IMPORTANT DATA AS 

2798
01:45:46,928 --> 01:45:48,096
WELL.

2799
01:45:48,096 --> 01:45:48,397
ABSOLUTELY.

2800
01:45:48,397 --> 01:45:49,531
THERE ARE A NUMBER OF DIFFERENT 

2801
01:45:49,531 --> 01:45:52,367
TOOLS THAT ARE USED IMPLEMENTED 

2802
01:45:52,367 --> 01:45:54,102
BY THE FEDERAL GOVERNMENT TO 

2803
01:45:54,102 --> 01:45:55,037
CAPTURE IMPORTANT DATA.

2804
01:45:55,037 --> 01:45:57,439
I CAN'T REALLY COMMENT ON N 

2805
01:45:57,439 --> 01:45:59,675
HAYNES OR OTHER TOOLS, OTHER 

2806
01:45:59,675 --> 01:45:59,908
SURVEYS.

2807
01:45:59,908 --> 01:46:01,710
I CAN SAY THAT WE ARE AWARE OF 

2808
01:46:01,710 --> 01:46:03,578
THE FACT THAT IT IS VERY 

2809
01:46:03,578 --> 01:46:04,313
IMPORTANT TO MAKE SURE THESE 

2810
01:46:04,313 --> 01:46:06,281
DATA ARE PROTECTED AND AVAILABLE

2811
01:46:06,281 --> 01:46:07,015
TO THE PUBLIC.

2812
01:46:07,015 --> 01:46:08,884
AND WE TAKE A NUMBER OF 

2813
01:46:08,884 --> 01:46:10,919
DIFFERENT MEASURES TO MAKE THAT 

2814
01:46:10,919 --> 01:46:11,386
HAPPEN.

2815
01:46:11,386 --> 01:46:13,655
SOMETIMES OUR DATA ARE SENT OVER

2816
01:46:13,655 --> 01:46:16,058
TO ICPSR TO THE UNIVERSITY OF 

2817
01:46:16,058 --> 01:46:16,958
MICHIGAN BECAUSE THEY, OF 

2818
01:46:16,958 --> 01:46:19,294
COURSE, ARE A GREAT PORTAL FOR 

2819
01:46:19,294 --> 01:46:19,628
DATA SETS.

2820
01:46:19,628 --> 01:46:21,196
AND WE ALSO ARE MAKING SURE 

2821
01:46:21,196 --> 01:46:25,033
PEOPLE HAVE LINKING THAT ARE 

2822
01:46:25,033 --> 01:46:26,401
USEFUL, LINKS THAT HAVEN'T BEEN 

2823
01:46:26,401 --> 01:46:26,635
BROKEN.

2824
01:46:26,635 --> 01:46:27,969
WE ARE DOING WHATEVER WE CAN.

2825
01:46:27,969 --> 01:46:29,705
WE ARE ALSO, HOW SHALL I SAY 

2826
01:46:29,705 --> 01:46:32,541
THIS, WE ARE TRYING VERY HARD TO

2827
01:46:32,541 --> 01:46:34,743
MAKE SURE OUR SURVEYS, SURVEY 

2828
01:46:34,743 --> 01:46:37,612
CONTENT AND USE OF SURVEYS IS 

2829
01:46:37,612 --> 01:46:38,914
CONSISTENT WITH ADMINISTRATOR 

2830
01:46:38,914 --> 01:46:39,214
PRIORITIES.

2831
01:46:39,214 --> 01:46:41,650
AND WE HAVE TO DO THAT IN A WAY 

2832
01:46:41,650 --> 01:46:42,951
THAT MAKES SURE THAT THE DATA 

2833
01:46:42,951 --> 01:46:44,252
CONTINUE TO BE USED AND 

2834
01:46:44,252 --> 01:46:45,520
AVAILABLE AND ARE NOT GOING TO 

2835
01:46:45,520 --> 01:46:48,790
RUN INTO ANY PROBLEMS.

2836
01:46:48,790 --> 01:46:49,391
>> THANK YOU.

2837
01:46:49,391 --> 01:46:49,991
>> OKAY.

2838
01:46:49,991 --> 01:46:52,461
I THINK WE ARE GOING TO MOVE ON 

2839
01:46:52,461 --> 01:46:55,364
BECAUSE IT IS TIME.

2840
01:46:55,364 --> 01:46:57,766
AND WE ARE GOING TO, FOR THOSE 

2841
01:46:57,766 --> 01:46:59,935
OF US HERE IN THE EAST COAST, 

2842
01:46:59,935 --> 01:47:01,336
WE'RE GOING TO GET A BREAK TO 

2843
01:47:01,336 --> 01:47:08,643
EAT SOMETHING, I HOPE.

2844
01:47:08,643 --> 01:47:11,747
SO TWO THINGS REALLY QUICKLY.

2845
01:47:11,747 --> 01:47:15,417
FIRST CHRIS BRADLEY IS THE IT 

2846
01:47:15,417 --> 01:47:16,118
PERSON RUNNING THE SHOW AND 

2847
01:47:16,118 --> 01:47:17,285
DOING A GREAT JOB.

2848
01:47:17,285 --> 01:47:19,187
HE DID IT YESTERDAY, TOO.

2849
01:47:19,187 --> 01:47:21,089
JUST WANT TO GIVE A SHOUTOUT TO 

2850
01:47:21,089 --> 01:47:21,289
CHRIS.

2851
01:47:21,289 --> 01:47:25,961
AND THEN WE HAVE ANOTHER CHRIS.

2852
01:47:25,961 --> 01:47:28,563
CHRISTOPHER SARAMPOTE IS THE 

2853
01:47:28,563 --> 01:47:34,536
DIRECTOR OF THE HEALTHY BABY 

2854
01:47:34,536 --> 01:47:35,704
COGNITIVE DEVELOPMENT STUDY.

2855
01:47:35,704 --> 01:47:37,339
DID I GET THAT RIGHT?

2856
01:47:37,339 --> 01:47:39,741
I ALWAYS FORGET THAT ACRONYM.

2857
01:47:39,741 --> 01:47:39,908
NO.

2858
01:47:39,908 --> 01:47:42,310
I DIDN'T GET IT RIGHT.

2859
01:47:42,310 --> 01:47:45,714
SUSAN, WHAT IS IT.

2860
01:47:45,714 --> 01:47:48,016
HEALTHY BRAIN AND CHILD 

2861
01:47:48,016 --> 01:47:50,218
DEVELOPMENT STUDY.

2862
01:47:50,218 --> 01:47:54,089
HE IS GOING TO PROVIDE UPDATES 

2863
01:47:54,089 --> 01:47:55,657
ON THE HBCD STUDY.

2864
01:47:55,657 --> 01:47:57,959
CHRISTOPHER IT IS ALL YOURS.

2865
01:47:57,959 --> 01:47:59,628
>> THANKS TO EVERYONE FOR
THE 

2866
01:47:59,628 --> 01:48:00,862
OPPORTUNITY TO PRESENT ABOUT 

2867
01:48:00,862 --> 01:48:01,062
HBCD.

2868
01:48:01,062 --> 01:48:03,098
I'M KEENLY AWARE I'M STANDING 

2869
01:48:03,098 --> 01:48:05,901
BETWEEN FOLKS AND A BREAK AND 

2870
01:48:05,901 --> 01:48:06,201
LUNCH.

2871
01:48:06,201 --> 01:48:08,503
SO I WILL ENDEAVOR TO KEEP 

2872
01:48:08,503 --> 01:48:09,938
THINGS MOVING.

2873
01:48:09,938 --> 01:48:12,874
I'M CHRISTOPHER SARAMPOTE, 

2874
01:48:12,874 --> 01:48:15,210
PROJECT DIRECTOR ON HBCD.

2875
01:48:15,210 --> 01:48:21,283
I'M JOINED BY JANANI PRABHAKAR, 

2876
01:48:21,283 --> 01:48:22,984
THE PROGRAM OFFICER 

2877
01:48:22,984 --> 01:48:24,019
ADMINISTERING THE SERIES OF 

2878
01:48:24,019 --> 01:48:24,853
GRANTS.

2879
01:48:24,853 --> 01:48:27,589
I'M JOINED BY THE TALENTED NIDA 

2880
01:48:27,589 --> 01:48:29,458
TEAM THAT MAKE HBCD HAPPEN.

2881
01:48:29,458 --> 01:48:32,194
WE ARE A SMALL TEAM FOR HBCD, 

2882
01:48:32,194 --> 01:48:35,664
BUT A LARGE GROUP OF PEOPLE WHO 

2883
01:48:35,664 --> 01:48:36,064
CONTRIBUTE.

2884
01:48:36,064 --> 01:48:45,207
I WANT TO THANK -- IT TRULY 

2885
01:48:45,207 --> 01:48:47,008
TAKES A LARGE VILLAGE TO HANDLE 

2886
01:48:47,008 --> 01:48:50,445
A STUDY OF THIS SIZE AND I'M 

2887
01:48:50,445 --> 01:48:53,148
APPRECIATIVE FOR THEIR SUPPORT.

2888
01:48:53,148 --> 01:48:58,787
AND I WOULD LIKE TO MOVE ON.

2889
01:48:58,787 --> 01:48:59,454
THERE WE GO.

2890
01:48:59,454 --> 01:49:02,457
SO JUST FOR FOLKS AS AN OVERVIEW

2891
01:49:02,457 --> 01:49:05,994
AND A REMINDER BUT ALSO FOR 

2892
01:49:05,994 --> 01:49:08,396
FOLKS WHO MAY BE NEW TO HBCD.

2893
01:49:08,396 --> 01:49:16,104
THIS IS A LARGE SCALE 10-YEAR 

2894
01:49:16,104 --> 01:49:16,872
LONGITUDINAL STUDY.

2895
01:49:16,872 --> 01:49:20,108
WE ARE BUILDING ON THE LESSONS 

2896
01:49:20,108 --> 01:49:23,178
FROM THE ABCD STUDY AND TAILORED

2897
01:49:23,178 --> 01:49:24,679
TO SPECIFIC POP LEIGH.

2898
01:49:24,679 --> 01:49:26,548
24 RECRUITMENT SITES ON THE MAP 

2899
01:49:26,548 --> 01:49:29,751
ON THE SCREEN TO THE LEFT, THE 

2900
01:49:29,751 --> 01:49:32,187
BLUE PINNING SPAN URBAN, 

2901
01:49:32,187 --> 01:49:33,822
SUBURBAN AND RURAL COMMUNITIES.

2902
01:49:33,822 --> 01:49:35,357
HELPING US REFLECT THE RICH 

2903
01:49:35,357 --> 01:49:37,058
DIVERSITY OF THE U.S. 

2904
01:49:37,058 --> 01:49:37,359
POPULATION.

2905
01:49:37,359 --> 01:49:40,161
THE CONSORTIUM IS COORDINATED BY

2906
01:49:40,161 --> 01:49:42,330
TWO CORES REPRESENTED BY THE 

2907
01:49:42,330 --> 01:49:45,400
GREEN AND DARK BLUE PINS.

2908
01:49:45,400 --> 01:49:47,402
THE ADMINISTRATIVE CORE IN SAN 

2909
01:49:47,402 --> 01:49:48,803
DIEGO AND BOSTON CHILDREN'S 

2910
01:49:48,803 --> 01:49:50,805
HOSPITAL AND THE DATA 

2911
01:49:50,805 --> 01:49:52,641
COORDINATING CENTER, WASH U, 

2912
01:49:52,641 --> 01:49:54,175
UNIVERSITY OF MINNESOTA AND UC 

2913
01:49:54,175 --> 01:49:55,143
SAN DIEGO.

2914
01:49:55,143 --> 01:49:57,279
PARTICIPANTS ARE ENROLLED IN THE

2915
01:49:57,279 --> 01:50:07,789
SECOND TRIMESTER OF PREGNANCY.

2916
01:50:09,558 --> 01:50:12,727
THIS STUDY IS FUNDED BY THE NIH 

2917
01:50:12,727 --> 01:50:15,730
HEEL INITIATIVE AND SUPPORTED BY

2918
01:50:15,730 --> 01:50:19,501
12 SFUTS AND CENTERS.

2919
01:50:19,501 --> 01:50:20,402
THANK YOU TO MICHELLE RANK KIN 

2920
01:50:20,402 --> 01:50:24,005
AT HEAL AND IC STAFF AND THEIR 

2921
01:50:24,005 --> 01:50:27,142
COLLABORATIVES GROUP, SCIENTIFIC

2922
01:50:27,142 --> 01:50:28,777
EXPERTISE AND LEADERSHIP ARE 

2923
01:50:28,777 --> 01:50:31,580
KROIT CAL TO OUR SUCCESS.

2924
01:50:31,580 --> 01:50:35,083
THE HBCD ZUDY IS DESIGNED TO 

2925
01:50:35,083 --> 01:50:36,651
ANSWER QUESTIONS ABOUT EARLY 

2926
01:50:36,651 --> 01:50:37,252
CHILDHOOD DEVELOPMENT.

2927
01:50:37,252 --> 01:50:42,724
WHAT IS THE NORMAL RANGE FROM BE

2928
01:50:42,724 --> 01:50:44,192
BIRTH TO CHILDHOOD?

2929
01:50:44,192 --> 01:50:48,196
HOW DO BIOLOGICAL AND OTHER 

2930
01:50:48,196 --> 01:50:53,535
ENVIRONMENT FACTORS IMPACT?

2931
01:50:53,535 --> 01:50:56,738
HOW DOES EARLY LIFE EXPOSURE TO 

2932
01:50:56,738 --> 01:50:58,506
OPIOIDS, OTHER SUBSTANCES SUCH 

2933
01:50:58,506 --> 01:51:00,475
AS ALCOHOL, STIMULANTS TOBACCO 

2934
01:51:00,475 --> 01:51:04,379
AND OTHER ADVERSE VIRMTSAL 

2935
01:51:04,379 --> 01:51:06,881
CIRCUMSTANCE AFFECT 

2936
01:51:06,881 --> 01:51:07,215
TRAJECTORIES.

2937
01:51:07,215 --> 01:51:09,985
ARE THERE KEY WINDOWS TO ADVERSE

2938
01:51:09,985 --> 01:51:12,020
EXPOSURES AND THIS COULD BE 

2939
01:51:12,020 --> 01:51:12,854
STRESS.

2940
01:51:12,854 --> 01:51:16,191
EMILE YOR RATING INFLUENCES 

2941
01:51:16,191 --> 01:51:18,793
LATER INFLUENCE DEVELOPMENTAL 

2942
01:51:18,793 --> 01:51:19,060
OUTCOMES.

2943
01:51:19,060 --> 01:51:23,632
KEY DEVELOPMENTAL WINDOWS IN 

2944
01:51:23,632 --> 01:51:27,535
WHICH WE CAN CHANGE DIRECTORIES 

2945
01:51:27,535 --> 01:51:30,171
ON IMPACT OF CHILDREN'S LIVES.

2946
01:51:30,171 --> 01:51:32,574
HBCD IS INTENDED TO PROVIDE A 

2947
01:51:32,574 --> 01:51:35,810
RICH DATA SET FOR RESEARCHERS 

2948
01:51:35,810 --> 01:51:37,379
FOR FUTURE STUDY LIKE THE 

2949
01:51:37,379 --> 01:51:39,314
SUCCESSFUL ABCD PROGRAM.

2950
01:51:39,314 --> 01:51:43,518
HBCD AIMS TO ACCOMPLISH THROUGH 

2951
01:51:43,518 --> 01:51:44,152
DENSE DATA COLLECTION THROUGH 

2952
01:51:44,152 --> 01:51:46,221
THE FIRST THREE CAREERS OF LIFE 

2953
01:51:46,221 --> 01:51:47,055
UNTIL 10 YEARS OF AGE.

2954
01:51:47,055 --> 01:51:49,357
THIS IS UP TO THE FIRST THREE 

2955
01:51:49,357 --> 01:51:50,158
YEARS.

2956
01:51:50,158 --> 01:51:52,460
THE NUMBER OF VISITS.

2957
01:51:52,460 --> 01:51:56,097
NOT SHOWN HERE ARE 5 AND 7, 

2958
01:51:56,097 --> 01:51:56,598
VIRTUAL VISITS.

2959
01:51:56,598 --> 01:51:58,066
THEY COMPLETE QUESTIONNAIRES AND

2960
01:51:58,066 --> 01:52:01,469
RESEARCH ACTIVITIES RELATED TO 

2961
01:52:01,469 --> 01:52:02,570
DEVELOPMENTAL ORIGINS OF HEALTH 

2962
01:52:02,570 --> 01:52:03,505
AND DISEASE.

2963
01:52:03,505 --> 01:52:05,640
PREPREGNANCY AND PRENATAL 

2964
01:52:05,640 --> 01:52:07,142
FACTORS, ONGOING BIOLOGICAL 

2965
01:52:07,142 --> 01:52:08,743
FACTORS OF THE CHILD AND THE 

2966
01:52:08,743 --> 01:52:10,145
BIRTH PARTS.

2967
01:52:10,145 --> 01:52:12,080
MEASURE OF CAREGIVER 

2968
01:52:12,080 --> 01:52:12,781
INTERACTIONS, CHILD BEHAVIOR IN 

2969
01:52:12,781 --> 01:52:14,382
THE HOME ENVIRONMENT AND I WILL 

2970
01:52:14,382 --> 01:52:16,918
ADD SLIDES LATER TO DETAIL THIS.

2971
01:52:16,918 --> 01:52:20,789
UNDERSTANDING THE FACTORS FOR 

2972
01:52:20,789 --> 01:52:21,956
SOCIAL AND ENVIRONMENTAL 

2973
01:52:21,956 --> 01:52:25,293
DETERMINANTS OF HEALTH.

2974
01:52:25,293 --> 01:52:26,461
HBCD INVESTIGATORS AND THEIR 

2975
01:52:26,461 --> 01:52:27,829
WORK IS HIGH POTENTIAL FOR 

2976
01:52:27,829 --> 01:52:28,196
PUBLIC HEALTH.

2977
01:52:28,196 --> 01:52:30,932
THIS IS ONE OF THE REASONS WE 

2978
01:52:30,932 --> 01:52:33,468
BELIEVE THESE WILL HIGHLY 

2979
01:52:33,468 --> 01:52:35,904
CONSISTENT WITH HHS AND NIH 

2980
01:52:35,904 --> 01:52:36,204
PRIORITIES.

2981
01:52:36,204 --> 01:52:38,273
IT IS MOST COMPLETE ASSESSMENT 

2982
01:52:38,273 --> 01:52:41,710
OF CONTRIBUTING FACTORS, 

2983
01:52:41,710 --> 01:52:42,677
COLLECTING HIGH RESOLUTION 

2984
01:52:42,677 --> 01:52:44,679
BEHAVIORAL, NUTRITION AND 

2985
01:52:44,679 --> 01:52:45,880
MEDICAL DATA.

2986
01:52:45,880 --> 01:52:53,822
COMBINED WITH ABCD, HBCD CAN 

2987
01:52:53,822 --> 01:52:54,155
DETERMINE.

2988
01:52:54,155 --> 01:52:56,591
IN THE TWO STUDIES WE WILL COVER

2989
01:52:56,591 --> 01:52:58,760
ALL OF MENTAL ILLNESS IN THE 

2990
01:52:58,760 --> 01:53:01,096
EARLIER SIGNS AN SYMPTOMS, BUT 

2991
01:53:01,096 --> 01:53:03,331
ALSO OTHER DISEASES EL AS WELL.

2992
01:53:03,331 --> 01:53:05,800
DATA FROM HBCD WILL PROVIDE 

2993
01:53:05,800 --> 01:53:08,169
CRUCIAL INFORMATION ON HOW TO 

2994
01:53:08,169 --> 01:53:10,438
INTERVENE TO GUIDE POLICY 

2995
01:53:10,438 --> 01:53:11,539
DECISIONS TO PROMOTE CHILD 

2996
01:53:11,539 --> 01:53:11,773
HEALTH.

2997
01:53:11,773 --> 01:53:14,576
SO AS I MENTIONED, THIS IS IS AN

2998
01:53:14,576 --> 01:53:16,511
AMBITIOUS ZUDY WITH A BROAD 

2999
01:53:16,511 --> 01:53:18,847
RANGE OF ASSESSMENTS TO 

3000
01:53:18,847 --> 01:53:20,582
UNDERSTAND TYPICAL NEURODWROMT 

3001
01:53:20,582 --> 01:53:22,083
ACROSS THE FIRST STAGES OF LIFE.

3002
01:53:22,083 --> 01:53:24,119
THESE ARE KIDS INVOLVED WITH 

3003
01:53:24,119 --> 01:53:30,024
STUDY PIs, KIDS VOLUNTEER.

3004
01:53:30,024 --> 01:53:31,893
AND TO DO THIS WE NEED TO 

3005
01:53:31,893 --> 01:53:35,630
UNDERSTAND THE NORMAL RANGE OF 

3006
01:53:35,630 --> 01:53:40,435
VARIABILITY OF BRAIN DEVELOPMENT

3007
01:53:40,435 --> 01:53:41,035
USE.

3008
01:53:41,035 --> 01:53:42,504
SCANS OF BRAIN STRUCTURE AND 

3009
01:53:42,504 --> 01:53:43,805
BRAIN FUNCTION.

3010
01:53:43,805 --> 01:53:47,675
WE COLLECT EEG DATA THAT CAN BE 

3011
01:53:47,675 --> 01:53:48,510
COORDINATED ACROSS TIME.

3012
01:53:48,510 --> 01:53:50,378
THESE ASSESSMENTS COUPLED WITH 

3013
01:53:50,378 --> 01:53:53,481
THE RICH BEHAVIORAL AND 

3014
01:53:53,481 --> 01:53:54,949
COGNITIVE BEHAVIOR COLLECTED IN 

3015
01:53:54,949 --> 01:53:56,918
ABCD WILL ENABLE TO INFORM 

3016
01:53:56,918 --> 01:53:59,320
HEALTH OUTCOMES AND ADDRESS 

3017
01:53:59,320 --> 01:54:00,155
UNANSWERED QUESTIONS HOW 

3018
01:54:00,155 --> 01:54:01,923
DEVELOPMENT IS REPRESENTED IN 

3019
01:54:01,923 --> 01:54:05,994
AND DRIVEN BY THE BRAIN.

3020
01:54:05,994 --> 01:54:08,196
ONE OF THE MAJOR STRENGTHS OF 

3021
01:54:08,196 --> 01:54:13,034
HBCD AND ABCD IS THE LARGE SCALE

3022
01:54:13,034 --> 01:54:13,535
BIOSPECIMENS.

3023
01:54:13,535 --> 01:54:17,405
THEY ARE THE CORNERSTONE OF THE 

3024
01:54:17,405 --> 01:54:19,908
HBCD STUDY BECAUSE THEY GENERATE

3025
01:54:19,908 --> 01:54:22,710
RELIABLE DATA ON THE MECHANISMS,

3026
01:54:22,710 --> 01:54:26,314
GENETICS, PROTEINS, THAT MAY 

3027
01:54:26,314 --> 01:54:29,617
INFLUENCE NEURAL COGNITIVE 

3028
01:54:29,617 --> 01:54:29,884
BEHAVIOR.

3029
01:54:29,884 --> 01:54:31,486
SOCIAL DEVELOPMENT.

3030
01:54:31,486 --> 01:54:34,122
HELPS US UNDERSTAND IMPACT OF 

3031
01:54:34,122 --> 01:54:37,292
PRENATAL AND POST NATAL OUTCOME.

3032
01:54:37,292 --> 01:54:39,828
ONE OF THE GREAT THINGS TO IS 

3033
01:54:39,828 --> 01:54:41,462
SAMPLE BANKED FOR FUTURE 

3034
01:54:41,462 --> 01:54:41,729
RESEARCH.

3035
01:54:41,729 --> 01:54:44,199
WILL BE ACCESSIBLE TO THE 

3036
01:54:44,199 --> 01:54:45,900
BROADER SCIENTIFIC COMMUNITY TO 

3037
01:54:45,900 --> 01:54:50,738
NIH COHORTS OR ABCD BIOSPECIMEN 

3038
01:54:50,738 --> 01:54:51,806
ACCESS PORTAL.

3039
01:54:51,806 --> 01:54:54,509
WE COLLECT BLOOD, WHOLE BLOD, 

3040
01:54:54,509 --> 01:54:57,011
SERUM, PLASMA.

3041
01:54:57,011 --> 01:54:59,347
NAIL CLIPPINGS DURING PREGNANCY 

3042
01:54:59,347 --> 01:55:01,449
AND ONE MONTH POST PARTUM.

3043
01:55:01,449 --> 01:55:04,219
UN DURING PREGNANCY.

3044
01:55:04,219 --> 01:55:07,288
SALIVA AND IN-PERSON POST NATAL 

3045
01:55:07,288 --> 01:55:07,589
VISITS.

3046
01:55:07,589 --> 01:55:08,957
FROM CHILDREN WE COLLECT IN 

3047
01:55:08,957 --> 01:55:19,500
PERSON VISITS SALIVA, STOOL AND 

3048
01:55:21,302 --> 01:55:21,569
URINE.

3049
01:55:21,569 --> 01:55:24,005
THE OTHER THING I MENTIONED IS 

3050
01:55:24,005 --> 01:55:31,346
THESE BIOSPECIMENS STRENGTHEN 

3051
01:55:31,346 --> 01:55:40,889
THE REPORT FOR -- THE STUDY IS 

3052
01:55:40,889 --> 01:55:42,657
INNING COLLUSION OF DATA FROM 

3053
01:55:42,657 --> 01:55:42,891
STUDIES.

3054
01:55:42,891 --> 01:55:44,926
THE PROMISE OF GEOCODES AND LINK

3055
01:55:44,926 --> 01:55:47,161
TO OTHER DATA SETS.

3056
01:55:47,161 --> 01:55:50,932
GEOCODED ADDRESSES WILL LINK 

3057
01:55:50,932 --> 01:55:52,967
NEIGHBORHOOD LEVEL TO CAPTURE 

3058
01:55:52,967 --> 01:55:55,270
ENVIRONMENT DETERMINANTS AND 

3059
01:55:55,270 --> 01:55:58,072
EXTRACT MEDICAL RECORDS WITH 

3060
01:55:58,072 --> 01:55:58,973
EARLY CHILDHOOD PHYSICAL HEALTH 

3061
01:55:58,973 --> 01:56:01,976
TO ALLOW FOR THE STUDIES OF 

3062
01:56:01,976 --> 01:56:03,344
PREDICTORS FOR CHILD HEALTH.

3063
01:56:03,344 --> 01:56:05,647
MEASURES OF GROWTH, NUTRITION, 

3064
01:56:05,647 --> 01:56:07,181
SLEEP, SCREEN MEDIA USE, 

3065
01:56:07,181 --> 01:56:09,083
PHYSICAL ACTIVITIES, GREEN 

3066
01:56:09,083 --> 01:56:10,852
SPACE, MEDICAL AND VACCINATION 

3067
01:56:10,852 --> 01:56:12,220
HIFTS, VISION AND QUALITY OF 

3068
01:56:12,220 --> 01:56:14,889
LIFE.

3069
01:56:14,889 --> 01:56:16,457
I'M JUST GOING TO FLY THROUGH A 

3070
01:56:16,457 --> 01:56:17,692
COUPLE OF DIFFERENT JUST TO GIVE

3071
01:56:17,692 --> 01:56:20,595
YOU A SENSE OF THE COMPREHENSIVE

3072
01:56:20,595 --> 01:56:22,230
ASSESSMENT HBCD IS UNDERTAKING.

3073
01:56:22,230 --> 01:56:26,167
SO ADDITIONAL MEASURES CAPTURE 

3074
01:56:26,167 --> 01:56:28,603
PHYSIOLOGICAL DATA AND VISITS 

3075
01:56:28,603 --> 01:56:31,172
TWO AND THREE IN OUR STUDY FOR 

3076
01:56:31,172 --> 01:56:34,142
72 HOURS, THEY WEAR TWO MOVEMENT

3077
01:56:34,142 --> 01:56:40,381
SENSORS ON LEGS AND ARMBAND THAT

3078
01:56:40,381 --> 01:56:41,149
SHOWS HEART RATE.

3079
01:56:41,149 --> 01:56:41,749
THEY ARE CUTE.

3080
01:56:41,749 --> 01:56:44,185
THE PARENTS GET TO PICK OUT THE 

3081
01:56:44,185 --> 01:56:44,619
DESIGNS.

3082
01:56:44,619 --> 01:56:46,788
THEY DETECT HEART RATE, OXYGEN 

3083
01:56:46,788 --> 01:56:49,691
SATURATION AND RESPIRATION RATE.

3084
01:56:49,691 --> 01:56:52,460
THIS ALLOWS US TO SET SLEEP 

3085
01:56:52,460 --> 01:56:55,763
WEIGHT CYCLES, PATTERNS OF 

3086
01:56:55,763 --> 01:56:57,999
MOVEMENT, PATTERNS OF AUTONOMIC 

3087
01:56:57,999 --> 01:56:59,968
NERVOUS SYSTEM FUNCTIONING.

3088
01:56:59,968 --> 01:57:02,704
OVER MULTIPLE TIME POINTS THE 

3089
01:57:02,704 --> 01:57:07,608
HBCD STUDY USES COGNITIVE 

3090
01:57:07,608 --> 01:57:09,978
DEVELOPMENT AND THE TOOL BOX OF 

3091
01:57:09,978 --> 01:57:11,446
INFANT AND TODDLERS AND OTHERS.

3092
01:57:11,446 --> 01:57:12,680
HERE IS JUST A SAMPLING.

3093
01:57:12,680 --> 01:57:15,650
THIS IS NOT THE FULL RANGE, A 

3094
01:57:15,650 --> 01:57:19,420
SAMPLING OF THE DOMAINS 

3095
01:57:19,420 --> 01:57:19,687
CAPTURED.

3096
01:57:19,687 --> 01:57:20,722
ANOTHER THING I WOULD LIKE TO 

3097
01:57:20,722 --> 01:57:23,291
POINT OUT, TOO, THESE INCLUDE 

3098
01:57:23,291 --> 01:57:24,859
CAREGIVER REPORTS IN RED AND 

3099
01:57:24,859 --> 01:57:27,095
OBJECTIVE MEASURES IN BLUE.

3100
01:57:27,095 --> 01:57:27,895
MULTIPLE POINTS OF DEVELOPMENT 

3101
01:57:27,895 --> 01:57:31,599
WE ARE GETTING MULTIPLE REPORTS 

3102
01:57:31,599 --> 01:57:33,468
WHETHER THERE ARE OBJECTIVE 

3103
01:57:33,468 --> 01:57:35,636
MEASURES OF A CHILD BEHAVIOR AND

3104
01:57:35,636 --> 01:57:36,671
COGNITIVE FUNCTIONING AND 

3105
01:57:36,671 --> 01:57:38,039
LANGUAGE DEVELOPMENT.

3106
01:57:38,039 --> 01:57:39,941
FINALLY, WITH THE ASSESSMENTS, 

3107
01:57:39,941 --> 01:57:43,444
HBCD STUDY CHARTS BEHAVIORAL 

3108
01:57:43,444 --> 01:57:44,912
DEVELOPMENT AND CHILD CAREGIVER 

3109
01:57:44,912 --> 01:57:47,048
INTERACTIONS IN FAMILY 

3110
01:57:47,048 --> 01:57:48,049
ENVIRONMENTS OBSERVATIONS AND 

3111
01:57:48,049 --> 01:57:48,750
SEVENTY REPORT.

3112
01:57:48,750 --> 01:57:50,852
WE HAVE PLAY SCENARIOS IN WHICH 

3113
01:57:50,852 --> 01:57:53,888
MOTHERS AND THEIR CHILDREN PLAY 

3114
01:57:53,888 --> 01:57:55,923
AND INTERACTIONS ARE 

3115
01:57:55,923 --> 01:57:57,325
STANDARDIZED, RECORDS AND STORED

3116
01:57:57,325 --> 01:57:58,159
FOR FUTURE USE.

3117
01:57:58,159 --> 01:58:02,730
CODED BY A CENTRALIZED TEAM TO 

3118
01:58:02,730 --> 01:58:04,065
MAXIMIZE ASSESSMENT RELIABILITY.

3119
01:58:04,065 --> 01:58:08,102
THAT WAS A FLY BY OF THE 

3120
01:58:08,102 --> 01:58:08,436
OVERVIEW.

3121
01:58:08,436 --> 01:58:10,238
WHAT HAVE WE DONE SINCE CRAN 

3122
01:58:10,238 --> 01:58:14,642
LAST MET IN 2024?

3123
01:58:14,642 --> 01:58:16,878
I'D LIKE TO -- THE FEELING THAT 

3124
01:58:16,878 --> 01:58:18,679
COMES TO MIND WHEN I THINK ABOUT

3125
01:58:18,679 --> 01:58:21,949
THIS, IF YOU HAVE EVER BEEN ON A

3126
01:58:21,949 --> 01:58:23,918
FISHING BOAT PILOTING OUT OF THE

3127
01:58:23,918 --> 01:58:26,220
HARBOR, THERE IS A LOT OF FOCUS.

3128
01:58:26,220 --> 01:58:29,257
YOU DON'T MESS WITH THE CAPTAIN.

3129
01:58:29,257 --> 01:58:31,192
THEY ARE FOCUSED ON NOT BUMPING 

3130
01:58:31,192 --> 01:58:32,527
INTO THINGS AND GETTING ON 

3131
01:58:32,527 --> 01:58:32,727
TRACK.

3132
01:58:32,727 --> 01:58:34,929
THAT IS WHERE I FEEL WE ARE.

3133
01:58:34,929 --> 01:58:37,698
WORKING HARD TO MAKE SURE THE 

3134
01:58:37,698 --> 01:58:41,369
SUCCESS WE HAD LAUNCHING THE 

3135
01:58:41,369 --> 01:58:44,372
STUDY CONTINUES WITH RECRUI

3136
01:58:44,372 --> 01:58:44,672
RECRUITMENT.

3137
01:58:44,672 --> 01:58:47,041
I'M EXCITED TO REPORT AND THESE 

3138
01:58:47,041 --> 01:58:50,044
ARE NUMBERS WE UPDATED TWO DAYS 

3139
01:58:50,044 --> 01:58:52,246
AGO, 104% OF OUR TARGET AND 

3140
01:58:52,246 --> 01:58:53,481
ALMOST HALFWAY POINT.

3141
01:58:53,481 --> 01:58:55,516
THERE WILL BE A BIG CELEBRATION 

3142
01:58:55,516 --> 01:58:57,051
WHEN WE GET TO THE HANDFULWAY.

3143
01:58:57,051 --> 01:58:58,519
WE ARE 34, 35.

3144
01:58:58,519 --> 01:59:01,389
SO CLOSE TO THE 3,500.

3145
01:59:01,389 --> 01:59:03,558
WE ARE VERY EXCITED ABOUT THAT.

3146
01:59:03,558 --> 01:59:08,696
IT SHOWS OVER THESE 24 SITES, 

3147
01:59:08,696 --> 01:59:11,432
THAT OUR STAFF, OUR RAs, OUR 

3148
01:59:11,432 --> 01:59:13,000
SITE MONITORS, THE EXPIRE TEAMS 

3149
01:59:13,000 --> 01:59:14,669
ARE VERY MUCH FOCUSED AND DRIVEN

3150
01:59:14,669 --> 01:59:16,637
ON INVITING AND ENGAGING 

3151
01:59:16,637 --> 01:59:18,172
FAMILIES TO PARTICIPATE IN THE 

3152
01:59:18,172 --> 01:59:19,373
HBCD STUDY.

3153
01:59:19,373 --> 01:59:21,709
THIS BY THE WAY REPRESENTS MORE 

3154
01:59:21,709 --> 01:59:24,846
THAN 20,000, OR 20,600 

3155
01:59:24,846 --> 01:59:26,047
INDIVIDUAL SUBJECT VISITS.

3156
01:59:26,047 --> 01:59:28,549
SO STAFF ARE WORKING OVERTIME 

3157
01:59:28,549 --> 01:59:30,218
LITERALLY TO BE ACCOMMODATING 

3158
01:59:30,218 --> 01:59:31,219
AND ENGAGE FAMILIES IN THE 

3159
01:59:31,219 --> 01:59:31,786
STUDY.

3160
01:59:31,786 --> 01:59:33,154
THE REASON FOR THE SUCCESS 

3161
01:59:33,154 --> 01:59:34,222
INCLUDE THE EXTRAORDINARY EFFORT

3162
01:59:34,222 --> 01:59:36,691
AND EXPERTISE OF OUR SITE 

3163
01:59:36,691 --> 01:59:39,060
RESEARCH ASSISTANTS, MONITORS 

3164
01:59:39,060 --> 01:59:42,096
AND THE INCORPORATION OF STUDY 

3165
01:59:42,096 --> 01:59:43,431
NAVIGATORS WITH LIVED EXPERIENCE

3166
01:59:43,431 --> 01:59:45,800
ARE A RESOURCE FOR OUR 

3167
01:59:45,800 --> 01:59:47,068
PARTICIPANTS AND FEEDBACK TO OUR

3168
01:59:47,068 --> 01:59:47,635
INVESTIGATORS.

3169
01:59:47,635 --> 01:59:49,270
THE INCLUSION OF COMMUNITY 

3170
01:59:49,270 --> 01:59:51,139
ADVISORY BOARDS FROM 

3171
01:59:51,139 --> 01:59:53,441
PARTNERSHIPS WITH COMMUNITY 

3172
01:59:53,441 --> 01:59:56,144
RESOURCES AND REFERRALS.

3173
01:59:56,144 --> 01:59:58,479
ADDITION OF SUPPLEMENT FUNDS 

3174
01:59:58,479 --> 02:00:01,482
LAST SUMMER FOR SITE LEVEL 

3175
02:00:01,482 --> 02:00:02,750
RECRUITMENT.

3176
02:00:02,750 --> 02:00:06,454
RECRUITMENT AND RETENTION LEVELS

3177
02:00:06,454 --> 02:00:07,755
LED BY THE UNIVERSITY OF 

3178
02:00:07,755 --> 02:00:09,724
MARYLAND WHO IS MONITORING AND 

3179
02:00:09,724 --> 02:00:10,491
KEEPING A CLOSE LOOK.

3180
02:00:10,491 --> 02:00:12,160
I WANT TO HIGHLIGHT THE EFFORTS 

3181
02:00:12,160 --> 02:00:15,296
OF -- SHE IS A PROGRAM OFFICER 

3182
02:00:15,296 --> 02:00:16,898
AND COLLECTS METRICS DATA AS 

3183
02:00:16,898 --> 02:00:19,534
PART OF A RESULTS-BASED 

3184
02:00:19,534 --> 02:00:20,601
ACCOUNTABILITY APPROACH AND SHE 

3185
02:00:20,601 --> 02:00:21,969
CAN ANSWER QUESTIONS ON THAT, 

3186
02:00:21,969 --> 02:00:22,336
TOO.

3187
02:00:22,336 --> 02:00:24,238
ALL IN ALL, YOU CAN SEE THIS IS 

3188
02:00:24,238 --> 02:00:26,007
JUST A NUMBER OF OUR 

3189
02:00:26,007 --> 02:00:28,576
RESEARCHERS, BUT STUDY 

3190
02:00:28,576 --> 02:00:29,777
NAVIGATORS AS A TRAINING LAES 

3191
02:00:29,777 --> 02:00:33,247
YEAR WORKING TO KEEP OUR 

3192
02:00:33,247 --> 02:00:34,949
FAMILIES ENGAGED AND KEEP US 

3193
02:00:34,949 --> 02:00:35,249
SUCCESSFUL.

3194
02:00:35,249 --> 02:00:38,986
SO LET ME TALK ABOUT SUBSTANCE 

3195
02:00:38,986 --> 02:00:40,788
USE IN OUR SAMPLE.

3196
02:00:40,788 --> 02:00:43,558
FOCUS ON SUBSTANCE EXPOSURES, 

3197
02:00:43,558 --> 02:00:46,327
APPROXIMATELY 3% OF SAMPLE 

3198
02:00:46,327 --> 02:00:47,762
CRITERIA HAD SOME FORM OF 

3199
02:00:47,762 --> 02:00:48,763
SUBSTANCE USE DURING PREGNANCY.

3200
02:00:48,763 --> 02:00:50,865
THIS IS CONFIRMED BY REPORTS 

3201
02:00:50,865 --> 02:00:53,367
THROUGH THE ASSIST OR TIMELINE 

3202
02:00:53,367 --> 02:00:57,471
FOLLOWBACK, BUT ALSO VERIFIED OR

3203
02:00:57,471 --> 02:01:01,375
ADDED TO BY TOXICOLOGY OF NAILS,

3204
02:01:01,375 --> 02:01:06,380
ESPNU -- URINE AND BLOOD.

3205
02:01:06,380 --> 02:01:10,785
LAST YEAR WE REPRESENTED 4%.

3206
02:01:10,785 --> 02:01:12,220
THAT IS A SIGNIFICANT INCREASE.

3207
02:01:12,220 --> 02:01:14,322
WE ARE AIMING TO OVERSAMPLE AND 

3208
02:01:14,322 --> 02:01:16,390
AIMING TO HIT 12%, THAT IS OUR 

3209
02:01:16,390 --> 02:01:17,725
GOAL FOR THE TOTAL SAMPLE.

3210
02:01:17,725 --> 02:01:19,927
THIS IS ONE OF THE -- OH, NOT 

3211
02:01:19,927 --> 02:01:21,295
REPRESENTATIVE HERE, BUT I WOULD

3212
02:01:21,295 --> 02:01:25,933
ALSO MENTION BECAUSE WE ARE 

3213
02:01:25,933 --> 02:01:27,001
TRACKING THIS AND IN FUTURE 

3214
02:01:27,001 --> 02:01:28,536
SLIDES WE WILL HAVE THIS 

3215
02:01:28,536 --> 02:01:31,038
INFORMATION, ROUGHLY 8% FOR 

3216
02:01:31,038 --> 02:01:36,944
STIMULANT USE IN PREGNANCY AS 

3217
02:01:36,944 --> 02:01:37,144
WELL.

3218
02:01:37,144 --> 02:01:40,948
JUST A COUPLE OF THINGS DR. 

3219
02:01:40,948 --> 02:01:43,251
VOLKOW ALREADY POINTED OUT, WE 

3220
02:01:43,251 --> 02:01:44,852
SEE MULTISUBSTANCE USE WITHIN 

3221
02:01:44,852 --> 02:01:46,387
OUR SAMPLE AND WE ARE TRACKING 

3222
02:01:46,387 --> 02:01:47,288
THIS AS WELL.

3223
02:01:47,288 --> 02:01:49,290
BUT LET ME JUST MENTION ABOUT 

3224
02:01:49,290 --> 02:01:49,824
OPIOIDS.

3225
02:01:49,824 --> 02:01:52,193
THIS SOMEONE OF THE MOST 

3226
02:01:52,193 --> 02:01:53,661
CHALLENGING ASPECTS OF HBCD IN 

3227
02:01:53,661 --> 02:01:56,530
PART TO THE LOWER OPIOID USE OF 

3228
02:01:56,530 --> 02:01:58,699
PREGNANT WOMEN NATIONALLY, THE 

3229
02:01:58,699 --> 02:02:00,301
MARGINALIZATION OF WOMENS, 

3230
02:02:00,301 --> 02:02:01,969
STIGMA AND CONCERNS ABOUT LEGAL 

3231
02:02:01,969 --> 02:02:03,804
INVOLVEMENT MAY BE A DETERRENT 

3232
02:02:03,804 --> 02:02:05,306
FOR PEOPLE TO PARTICIPATE IN OUR

3233
02:02:05,306 --> 02:02:05,506
STUDY.

3234
02:02:05,506 --> 02:02:08,809
THAT SAID, WE HAVE BEEN REALLY 

3235
02:02:08,809 --> 02:02:11,679
PLEASED WITH THE EFFORT OUR 

3236
02:02:11,679 --> 02:02:14,048
SITES HAVE MADE TO ENGAGE 

3237
02:02:14,048 --> 02:02:16,217
MOTHERS WHO USE SUBSTANCES, 

3238
02:02:16,217 --> 02:02:17,752
PARTICULARLY OPIOID.

3239
02:02:17,752 --> 02:02:22,556
THESE ARE NOT ONE TO ONE 

3240
02:02:22,556 --> 02:02:23,190
COMPAR

3241
02:02:23,190 --> 02:02:26,160
COMPARISONS, BUT SIMILARITIES 

3242
02:02:26,160 --> 02:02:33,067
BETWEEN HBCD AND PRAM AND NSDUH,

3243
02:02:33,067 --> 02:02:35,770
BOTH COLLECT DATA ON SUBSTANCE 

3244
02:02:35,770 --> 02:02:37,605
USE IN PREGNANCY.

3245
02:02:37,605 --> 02:02:40,541
7% OR 6.8% WE ARE DOING AT LEAST

3246
02:02:40,541 --> 02:02:42,677
AS WELL AS WE ARE EXCEEDING BOTH

3247
02:02:42,677 --> 02:02:44,979
THOSE TWO STUDIES WHICH WE ARE 

3248
02:02:44,979 --> 02:02:46,847
EXCITED ABOUT, BUT WE KNOW WE 

3249
02:02:46,847 --> 02:02:48,049
HAVE A LOT FURTHER TO GO.

3250
02:02:48,049 --> 02:02:50,151
I MENTIONED EARLIER AND I WANT 

3251
02:02:50,151 --> 02:02:51,752
TO FLY BY THESE QUICKLY.

3252
02:02:51,752 --> 02:02:54,922
ANCILLARY STUDIES ARE COLLECTING

3253
02:02:54,922 --> 02:02:59,427
ADDITIONAL BIOSPECIMENS FROM 

3254
02:02:59,427 --> 02:03:00,961
PARTICIPANTS IN ORDER TO HAVE, 

3255
02:03:00,961 --> 02:03:06,000
ONE, IN THIS CASE THE 

3256
02:03:06,000 --> 02:03:11,572
BIOSPECIMEN PREGNANCY TO BANK.

3257
02:03:11,572 --> 02:03:13,574
THIS IS A CORRECTION AND BANKING

3258
02:03:13,574 --> 02:03:17,645
OF DELIVERY SAMPLES, UMBILICAL 

3259
02:03:17,645 --> 02:03:20,881
CORD BLOOD AND TISSUE.

3260
02:03:20,881 --> 02:03:24,118
AS RECENTLY AS TWO DAYS AGO 

3261
02:03:24,118 --> 02:03:26,387
WHICH WE ARE EXCITED ABOUT OVER 

3262
02:03:26,387 --> 02:03:28,489
MULTIPLE SITES.

3263
02:03:28,489 --> 02:03:33,661
THE SECOND ANCILLARY STUDY BY A 

3264
02:03:33,661 --> 02:03:35,930
RO1, COLLECTING BLOOD AND PLA 

3265
02:03:35,930 --> 02:03:38,466
SENTAL SAMPLES FOR TARGETED 

3266
02:03:38,466 --> 02:03:40,434
DOWNSTREAM ASSAYS TO SEE HOW 

3267
02:03:40,434 --> 02:03:42,603
BIRTH PARENT FETAL PLACENTA 

3268
02:03:42,603 --> 02:03:44,538
DEVELOPMENT OUTCOMES MAY EMENCH.

3269
02:03:44,538 --> 02:03:48,209
ALMOST HALF OF THE TARGET, 400 

3270
02:03:48,209 --> 02:03:49,243
HAVE BEEN INVOLVED.

3271
02:03:49,243 --> 02:03:54,648
BOTH ANCILLARY STUDIES HAVE 

3272
02:03:54,648 --> 02:03:57,251
FEENO TYPING BEING DONE AS PART 

3273
02:03:57,251 --> 02:03:59,053
OF THE HBCD AND THEY ARE 

3274
02:03:59,053 --> 02:04:01,889
CO-ENROLLED IN HBCD.

3275
02:04:01,889 --> 02:04:03,958
SO MOST EXCITINGLY, WE ARE 

3276
02:04:03,958 --> 02:04:06,727
ANTICIPATING THE FIRST HBCD DATA

3277
02:04:06,727 --> 02:04:10,231
RELEASE NEXT MONTH PART OF THE 

3278
02:04:10,231 --> 02:04:11,899
NBDC DATA HUB.

3279
02:04:11,899 --> 02:04:14,135
PRENATAL, THIS IS ONE, IN THE 

3280
02:04:14,135 --> 02:04:17,505
SECOND OR THIRD TRIMESTER OF 

3281
02:04:17,505 --> 02:04:22,176
PREGNANCY ON 1400 MOTHERS.

3282
02:04:22,176 --> 02:04:28,249
M.R.I. AND BIOSENSITIVE DATA 600

3283
02:04:28,249 --> 02:04:30,484
PARTICIPANTS.

3284
02:04:30,484 --> 02:04:34,588
EX-EG WITH 3 TO 9 MONTHS AND 120

3285
02:04:34,588 --> 02:04:35,055
PARTICIPANTS.

3286
02:04:35,055 --> 02:04:38,659
THESE NUMBERS WILL UNDOUBTEDLY 

3287
02:04:38,659 --> 02:04:38,993
INCREASE.

3288
02:04:38,993 --> 02:04:40,361
THE IMPORTANT DATE THERE IS 

3289
02:04:40,361 --> 02:04:41,162
JUNE, NEXT MONTH.

3290
02:04:41,162 --> 02:04:44,632
WE ARE EXCITED THAT THIS IS 

3291
02:04:44,632 --> 02:04:46,901
HAPPENING AND YOU'LL HEAR MORE 

3292
02:04:46,901 --> 02:04:49,136
ABOUT THAT LATER ON AS WELL.

3293
02:04:49,136 --> 02:04:51,205
I WANT TO MAKE A QUICK NOTE.

3294
02:04:51,205 --> 02:04:53,340
I THINK FOLKS ARE FAMILIAR WITH 

3295
02:04:53,340 --> 02:04:53,774
THIS.

3296
02:04:53,774 --> 02:04:55,943
MANY FOLKS IN THIS ROOM HAVE 

3297
02:04:55,943 --> 02:04:57,178
CONTRIBUTED TO THIS SPESHTS 

3298
02:04:57,178 --> 02:04:58,746
ISSUE.

3299
02:04:58,746 --> 02:05:00,347
IF YOU WOULD LIKE TO LEARN MORE 

3300
02:05:00,347 --> 02:05:02,983
ABOUT HBCD, OUR PROTOCOLS AND 

3301
02:05:02,983 --> 02:05:05,286
THE GOALS THERE IS A WONDERFUL 

3302
02:05:05,286 --> 02:05:06,787
SPECIAL ISSUE THAT HAD BEEN 

3303
02:05:06,787 --> 02:05:09,190
EDITED BY MEMBERS OF THE PIs 

3304
02:05:09,190 --> 02:05:13,561
FROM HBCD AND YOU CAN LEARN MORE

3305
02:05:13,561 --> 02:05:13,828
THERE.

3306
02:05:13,828 --> 02:05:21,001
SO I WANT TO, ON BEHALF OF 

3307
02:05:21,001 --> 02:05:23,270
JANINE, I WANT TO PROVIDE NFLGS 

3308
02:05:23,270 --> 02:05:24,605
ON OUR TYPELINE.

3309
02:05:24,605 --> 02:05:28,642
WE ARE AT A HIGH STAKES POINT IN

3310
02:05:28,642 --> 02:05:29,243
TIME.

3311
02:05:29,243 --> 02:05:32,980
JULY 1 WE ARE STARTING OUR LAST 

3312
02:05:32,980 --> 02:05:35,649
YEAR OF OUR FIRST FIVE-YEAR 

3313
02:05:35,649 --> 02:05:37,117
FUNDING PERIOD FOR HBCD.

3314
02:05:37,117 --> 02:05:40,454
WE ARE CURRENTLY WORKING ON 

3315
02:05:40,454 --> 02:05:42,590
RENEWING HBCD.

3316
02:05:42,590 --> 02:05:43,891
IDEALLY AIMING FOR THE MAY 

3317
02:05:43,891 --> 02:05:45,793
COUNCIL NEXT YEAR WITH THE IDEA 

3318
02:05:45,793 --> 02:05:47,795
OF BEING BY JULY 1st TO START 

3319
02:05:47,795 --> 02:05:51,832
YEAR SIX OF HBCD.

3320
02:05:51,832 --> 02:05:56,337
SO WE ARE QUITE EXCITED.

3321
02:05:56,337 --> 02:05:59,540
THAT MIGHT BE THE FIGHT OR 

3322
02:05:59,540 --> 02:05:59,940
FLIGHT.

3323
02:05:59,940 --> 02:06:02,176
WE ARE EXCITED AND WORKING HARD.

3324
02:06:02,176 --> 02:06:06,180
I KNOW A NUMBER OF OUR PARTNERS 

3325
02:06:06,180 --> 02:06:09,817
HAVE WEIGHED IN ON THE NOFOs.

3326
02:06:09,817 --> 02:06:11,585
AND WE INVITE THEM TO.

3327
02:06:11,585 --> 02:06:13,754
WE ARE LOOKING FORWARD TO THE 

3328
02:06:13,754 --> 02:06:15,289
FINAL PUBLICATION HOPEFULLY THIS

3329
02:06:15,289 --> 02:06:15,956
SUMMER.

3330
02:06:15,956 --> 02:06:16,223
OKAY.

3331
02:06:16,223 --> 02:06:17,791
WITH THAT, I THANK YOU VERY MUCH

3332
02:06:17,791 --> 02:06:18,425
FOR YOUR TIME.

3333
02:06:18,425 --> 02:06:22,229
I THANK YOU FOR ENDURING ANY 

3334
02:06:22,229 --> 02:06:24,798
HUNGER PANGS AND HAPPY TO ANSWER

3335
02:06:24,798 --> 02:06:25,666
ANY QUESTIONS YOU HAVE.

3336
02:06:25,666 --> 02:06:26,433
>> THANK YOU, CHRIS.

3337
02:06:26,433 --> 02:06:29,537
THAT WAS GREAT.

3338
02:06:29,537 --> 02:06:31,605
SO QUESTIONS FROM COUNCIL?

3339
02:06:31,605 --> 02:06:34,875
ANY QUESTIONS OUT THERE?

3340
02:06:34,875 --> 02:06:36,210
>> YES, FROM DAVID.

3341
02:06:36,210 --> 02:06:38,979
>> YEAH.

3342
02:06:38,979 --> 02:06:39,213
THANKS.

3343
02:06:39,213 --> 02:06:42,950
SO I NOTICED THAT THE PRENATAL 

3344
02:06:42,950 --> 02:06:44,885
SUBSTANCE USE CRITERIA FOR 

3345
02:06:44,885 --> 02:06:48,489
ALCOHOL IS LISTED AS EQUAL TO OR

3346
02:06:48,489 --> 02:06:49,623
MORE THAN SEVEN STANDARD 

3347
02:06:49,623 --> 02:06:55,796
DRINKING A WEEK FOR MORE THAN 

3348
02:06:55,796 --> 02:06:56,463
TWO WEEKS.

3349
02:06:56,463 --> 02:06:58,899
OR EQUAL TO THREE STANDARD 

3350
02:06:58,899 --> 02:07:00,834
DRINKS ON OCCASION FOR MORE THAN

3351
02:07:00,834 --> 02:07:02,069
A COUPLE OF OCCASIONS.

3352
02:07:02,069 --> 02:07:05,239
I'M WONDERING WHAT THE 

3353
02:07:05,239 --> 02:07:06,340
RESOLUTION OF USE IS?

3354
02:07:06,340 --> 02:07:07,408
CAN YOU CHANGE THAT?

3355
02:07:07,408 --> 02:07:09,543
IS THAT A CHANGEABLE CRITERION?

3356
02:07:09,543 --> 02:07:14,315
CAN YOU GO LOWER THAN THAT OR IS

3357
02:07:14,315 --> 02:07:16,016
THAT ACQUIRED AS A CUTOFF LIKE 

3358
02:07:16,016 --> 02:07:16,216
THAT?

3359
02:07:16,216 --> 02:07:17,718
>> WE ARE COLLECTING THE
DATA.

3360
02:07:17,718 --> 02:07:20,588
I THINK IT DEPENDS ON THE ONE 

3361
02:07:20,588 --> 02:07:22,222
HAND I THINK WE CAN MINE DATA AT

3362
02:07:22,222 --> 02:07:24,224
THAT LEVEL, TYPICALLY WE ARE 

3363
02:07:24,224 --> 02:07:26,360
DESCRIBING IT AS POSITIVE USE.

3364
02:07:26,360 --> 02:07:28,228
IT COULD BE YES OR NO.

3365
02:07:28,228 --> 02:07:29,863
BUT WE DO HAVE HIGH RESOLUTION 

3366
02:07:29,863 --> 02:07:32,066
DATA THAT ARE AVAILABLE.

3367
02:07:32,066 --> 02:07:33,734
IT IS ALSO HIGH RESOLUTION 

3368
02:07:33,734 --> 02:07:36,270
BIOLOGICAL DATA FROM OUR 

3369
02:07:36,270 --> 02:07:37,538
BIOSAMPLES AND TOXICOLOGY 

3370
02:07:37,538 --> 02:07:39,106
ANNOUNCEMENTS AS WELL IN TERMS 

3371
02:07:39,106 --> 02:07:41,442
OF PATH AND OTHER MEASURES.

3372
02:07:41,442 --> 02:07:43,777
IT WOULD HELP US UNDERSTAND THE 

3373
02:07:43,777 --> 02:07:45,713
VARYING IMPACTS OF ALCOHOL ON 

3374
02:07:45,713 --> 02:07:46,013
DEVELOPMENT.

3375
02:07:46,013 --> 02:07:47,848
>> GREAT.

3376
02:07:47,848 --> 02:07:48,115
THANK YOU.

3377
02:07:48,115 --> 02:07:49,917
LOOKS LIKE A REALLY PROMISING 

3378
02:07:49,917 --> 02:07:50,150
PROJECT.

3379
02:07:50,150 --> 02:07:51,085
>> THANK YOU.

3380
02:07:51,085 --> 02:07:53,454
>> NORA, DID YOU HAVE A 

3381
02:07:53,454 --> 02:07:54,221
QUESTION?

3382
02:07:54,221 --> 02:07:54,455
COMMENT?

3383
02:07:54,455 --> 02:07:56,223
>> YES, YES, YES.

3384
02:07:56,223 --> 02:07:56,890
THANKS A LOT.

3385
02:07:56,890 --> 02:07:58,692
I DID HAVE A QUESTION AND I 

3386
02:07:58,692 --> 02:08:00,861
SHOULD KNOW IT, BUT I DON'T.

3387
02:08:00,861 --> 02:08:04,198
THIS WAS VERY NICE TO SEE, IN 

3388
02:08:04,198 --> 02:08:06,934
FACT, HOW SUCCESSFUL THE 

3389
02:08:06,934 --> 02:08:08,535
RECRUITMENT OF PARTICIPANTS HAS 

3390
02:08:08,535 --> 02:08:10,070
BEEN OVERALL AND HOW YOU ARE 

3391
02:08:10,070 --> 02:08:12,072
STARTING TO ACCELERATE THE 

3392
02:08:12,072 --> 02:08:14,241
NUMBER OF PARTICIPANTS EXPOSED 

3393
02:08:14,241 --> 02:08:16,377
TO OPIATES AND HOPEFULLY WE CAN 

3394
02:08:16,377 --> 02:08:19,346
REACH THE GOAL, BUT YOU DID NOT 

3395
02:08:19,346 --> 02:08:22,282
DWELL MUCH IN TERMS OF THE 

3396
02:08:22,282 --> 02:08:23,817
SOCIOECONOMIC BACKGROUNDS.

3397
02:08:23,817 --> 02:08:24,818
BECAUSE THAT WAS SOMETHING WE 

3398
02:08:24,818 --> 02:08:26,920
REALIZED FOR THE ABCD WE HAD 

3399
02:08:26,920 --> 02:08:29,390
BEEN VERY GOOD AT BRINGING 

3400
02:08:29,390 --> 02:08:32,726
UNDERREPRESENTED GROUPS.

3401
02:08:32,726 --> 02:08:36,430
BUT WE DID NOT BALANCE IT WELL 

3402
02:08:36,430 --> 02:08:37,898
VIS-A-VIS ECONOMIC BACKGROUNDS.

3403
02:08:37,898 --> 02:08:41,135
SO HOW ARE WE DOING WITH THE 

3404
02:08:41,135 --> 02:08:41,835
HBCD?

3405
02:08:41,835 --> 02:08:43,504
>> ACTUALLY, I HAVE A
SLIDE.

3406
02:08:43,504 --> 02:08:46,340
I WAS GOING TO SAY I CAN PULL UP

3407
02:08:46,340 --> 02:08:47,741
A SLIDE, BUT I CAN DESCRIBE IT 

3408
02:08:47,741 --> 02:08:48,742
TO YOU.

3409
02:08:48,742 --> 02:08:52,046
THIS IS SOMETHING THAT WE REALLY

3410
02:08:52,046 --> 02:08:54,148
BENEFIT FROM THE ABCD AND ALSO 

3411
02:08:54,148 --> 02:08:57,985
BEING IN A LOCATION WITH NEXT 

3412
02:08:57,985 --> 02:09:01,288
DOOR TO ABCD STAFF SO WE CAN 

3413
02:09:01,288 --> 02:09:02,923
TALK ABOUT THE LESSONS LEARNED 

3414
02:09:02,923 --> 02:09:03,857
ALONG THE WAY.

3415
02:09:03,857 --> 02:09:05,325
I JUST WANT TO SHARE THIS ONE 

3416
02:09:05,325 --> 02:09:06,660
SLIDE WITH FOLKS.

3417
02:09:06,660 --> 02:09:08,762
SO WE HAVE BECOME VERY CONCERNED

3418
02:09:08,762 --> 02:09:11,799
WITH THE DEMOGRAPHICS AND 

3419
02:09:11,799 --> 02:09:12,866
EXTERNAL VALIDITY OF OUR OUR 

3420
02:09:12,866 --> 02:09:13,133
SAMPLE.

3421
02:09:13,133 --> 02:09:15,069
THESE ARE OUR STUDY DEMOGRAPHICS

3422
02:09:15,069 --> 02:09:16,870
KURNTSLY.

3423
02:09:16,870 --> 02:09:20,207
-- KURNTSLY.

3424
02:09:20,207 --> 02:09:20,974
-- CURRENTLY.

3425
02:09:26,814 --> 02:09:26,980
AWESOME.

3426
02:09:26,980 --> 02:09:27,614
APPRECIATE IT.

3427
02:09:27,614 --> 02:09:33,654
CHRISS  LOOKING OUT FOR EACH 

3428
02:09:33,654 --> 02:09:33,854
OTHER.

3429
02:09:33,854 --> 02:09:35,489
THESE SPEAK FOR THEMSELVES.

3430
02:09:35,489 --> 02:09:37,925
SOME AREAS WE ARE REALLY DOING 

3431
02:09:37,925 --> 02:09:39,760
WELL IN TERMS OF YOU CAN 

3432
02:09:39,760 --> 02:09:42,229
DESCRIBE A LOT OF OUR SAMPLE AS 

3433
02:09:42,229 --> 02:09:47,601
BEING MORE HIGH LY EDUCATED OR 

3434
02:09:47,601 --> 02:09:48,936
HIGHER SES GROUPS.

3435
02:09:48,936 --> 02:09:52,539
WHEN WE TALK ABOUT RACE AND 

3436
02:09:52,539 --> 02:09:53,907
ETHNICITY, WE ARE DOING WELL 

3437
02:09:53,907 --> 02:09:56,477
WHEN IT COMES TO TRADITIONALLY 

3438
02:09:56,477 --> 02:09:57,611
UNDERREPRESENTED GROUPS.

3439
02:09:57,611 --> 02:09:59,780
WITH OUR WHITE SAMPLE WE ARE 

3440
02:09:59,780 --> 02:10:00,814
UNDER OUR TARGETS.

3441
02:10:00,814 --> 02:10:02,850
THIS IS SOMETHING WE ARE PAYING 

3442
02:10:02,850 --> 02:10:03,784
CLOSE ATTENTION TO.

3443
02:10:03,784 --> 02:10:06,820
ONE OF THE ENCOURAGING THINGS, 

3444
02:10:06,820 --> 02:10:07,688
ALTHOUGH, FOR EXAMPLE, WITH 

3445
02:10:07,688 --> 02:10:10,691
WHITE PARTICIPANTS WE ARE BELOW 

3446
02:10:10,691 --> 02:10:12,860
OUR TARGETS, IT IS STILL HIGH 

3447
02:10:12,860 --> 02:10:14,628
FREQUENCY COMPARED TO OTHER 

3448
02:10:14,628 --> 02:10:14,862
GROUPS.

3449
02:10:14,862 --> 02:10:16,930
WE ARE LOOKING CLOSELY WITH NOT 

3450
02:10:16,930 --> 02:10:20,601
ONLY OUR RECRUITMENT RETENTION, 

3451
02:10:20,601 --> 02:10:25,572
METRICS TEAM BUT BIOSTATISTICS 

3452
02:10:25,572 --> 02:10:29,510
TEAM HOW THIS ALLOWS US TO 

3453
02:10:29,510 --> 02:10:31,278
EVALUATE VARIOUS SUBGROUPS IN 

3454
02:10:31,278 --> 02:10:31,478
HBCD.

3455
02:10:31,478 --> 02:10:33,614
WE WORKED HARD TO MAKE SURE WE 

3456
02:10:33,614 --> 02:10:38,285
ARE ENGAGING SPECIFIC GROUPS 

3457
02:10:38,285 --> 02:10:41,321
SUCH AS HISPANIC OR LATINO 

3458
02:10:41,321 --> 02:10:41,989
GROUPS.

3459
02:10:41,989 --> 02:10:45,092
WE HAVE FUNDING TO ALLOW FOR 

3460
02:10:45,092 --> 02:10:47,027
INCREASED SPANISH LANGUAGE 

3461
02:10:47,027 --> 02:10:47,995
AVAILABILITY.

3462
02:10:47,995 --> 02:10:50,097
WE HAVE A SPANISH LANGUAGE 

3463
02:10:50,097 --> 02:10:54,134
WORKING GROUP IN HBCD, THAT 

3464
02:10:54,134 --> 02:11:01,241
FOCUSES ON NOT ONLY TRANSLATION 

3465
02:11:01,241 --> 02:11:03,710
MATERIALS, BUT WORKING WITH THE 

3466
02:11:03,710 --> 02:11:03,977
FAMILIES.

3467
02:11:03,977 --> 02:11:06,046
WE ARE IN YEAR TWO OF 

3468
02:11:06,046 --> 02:11:06,547
RECRUITMENT.

3469
02:11:06,547 --> 02:11:08,882
GETTING READY TO START YEAR 

3470
02:11:08,882 --> 02:11:09,583
THREE.

3471
02:11:09,583 --> 02:11:11,318
WE KNOW THE BOAT HAS LEFT THE 

3472
02:11:11,318 --> 02:11:12,920
HARBOR AND WE ARE MOVING OUT 

3473
02:11:12,920 --> 02:11:13,987
INTO THE CHANNEL.

3474
02:11:13,987 --> 02:11:15,689
NOW WE HAVE TO PAY ATTENTION TO 

3475
02:11:15,689 --> 02:11:18,058
GET THE REST OF THINGS ON TARGET

3476
02:11:18,058 --> 02:11:19,660
AND CHARTED TO BE ON COURSE.

3477
02:11:19,660 --> 02:11:22,496
AND SO WE ARE FOCUSING IN THOSE 

3478
02:11:22,496 --> 02:11:24,665
AREAS TO SEE WHAT KIND OF 

3479
02:11:24,665 --> 02:11:26,800
NUDGING ALONG THE WAY, WHAT 

3480
02:11:26,800 --> 02:11:27,801
RESOURCES CAN BE BROUGHT TO 

3481
02:11:27,801 --> 02:11:29,136
SUPPORT INDIVIDUAL SITES TO MAKE

3482
02:11:29,136 --> 02:11:31,171
SURE WE ARE HITTING THOSE 

3483
02:11:31,171 --> 02:11:31,405
TARGETS.

3484
02:11:31,405 --> 02:11:37,477
>> THANKS.

3485
02:11:37,477 --> 02:11:40,480
>> HOW DO I KILL THIS?

3486
02:11:40,480 --> 02:11:43,083
>> I THINK THERE IS ONE 

3487
02:11:43,083 --> 02:11:43,350
QUESTION.

3488
02:11:43,350 --> 02:11:44,218
>> YEAH.

3489
02:11:44,218 --> 02:11:45,352
ONE MORE QUESTION AND THEN WE 

3490
02:11:45,352 --> 02:11:52,025
ARE GOING TO TAKE A BREAK.

3491
02:11:52,025 --> 02:11:53,594
REMEMBER, EVERYBODY, YOU CAN GET

3492
02:11:53,594 --> 02:11:56,396
A HOLD OF ALL OF US ANY TIME YOU

3493
02:11:56,396 --> 02:11:58,131
WANT BY SENDING AN E-MAIL.

3494
02:11:58,131 --> 02:11:59,633
WE STILL RESPOND TO E-MAILS.

3495
02:11:59,633 --> 02:12:01,768
>> THIS IS A REALLY
TERRIFIC 

3496
02:12:01,768 --> 02:12:02,135
STUDY.

3497
02:12:02,135 --> 02:12:02,703
CONGRATULATIONS, CHRIS.

3498
02:12:02,703 --> 02:12:07,341
I DO HAVE A QUESTION ABOUT THE 

3499
02:12:07,341 --> 02:12:09,109
CONSIDERATION OF OTHER 

3500
02:12:09,109 --> 02:12:10,477
EXPERIENCES THAT MOTHERS MAY 

3501
02:12:10,477 --> 02:12:11,745
HAVE.

3502
02:12:11,745 --> 02:12:14,014
SO THINKING ABOUT NORA'S 

3503
02:12:14,014 --> 02:12:14,348
PRESENTATION.

3504
02:12:14,348 --> 02:12:17,451
IF WE THINK ABOUT THE EIGHT FOLD

3505
02:12:17,451 --> 02:12:19,486
INCREASE IN RISK FOR MOTHERS 

3506
02:12:19,486 --> 02:12:22,656
THAT THEY MAY HAVE AS A RESULT 

3507
02:12:22,656 --> 02:12:25,259
OF THEIR OWN CHILD 

3508
02:12:25,259 --> 02:12:26,326
EXPERIENCES,ED A VERAS CHILDHOOD

3509
02:12:26,326 --> 02:12:27,628
EXPERIENCES OR ACES.

3510
02:12:27,628 --> 02:12:28,962
IS THAT SOMETHING YOU ARE 

3511
02:12:28,962 --> 02:12:31,531
ADDRESSING AS WELL?

3512
02:12:31,531 --> 02:12:31,965
>> YES.

3513
02:12:31,965 --> 02:12:34,868
SO AT THE BEGINNING OF THAT 

3514
02:12:34,868 --> 02:12:37,604
FIRST VISIT WE TAKE -- AND THESE

3515
02:12:37,604 --> 02:12:40,774
ARE EIGHT-HOUR-DAYS.

3516
02:12:40,774 --> 02:12:42,576
SO IT IS QUITE INVOLVED.

3517
02:12:42,576 --> 02:12:45,078
AND THOSE INCLUDE VERY DEEP 

3518
02:12:45,078 --> 02:12:46,780
DETAILED ASSESSMENTS OF PAST 

3519
02:12:46,780 --> 02:12:48,949
HISTORY, ACES, TRAUMA HISTORIES 

3520
02:12:48,949 --> 02:12:50,584
WITHIN MOTHERS AND SO I THINK 

3521
02:12:50,584 --> 02:12:52,185
THAT IS ONE OF THE WONDERFUL 

3522
02:12:52,185 --> 02:12:53,387
THINGS ABOUT HBCD.

3523
02:12:53,387 --> 02:12:56,623
YES, WE HAVE BIOSPECIMENS, 

3524
02:12:56,623 --> 02:13:00,227
IMAGING AND VERY RICH 

3525
02:13:00,227 --> 02:13:01,261
SOCIODEMOGRAPHIC AND PERSONAL 

3526
02:13:01,261 --> 02:13:02,663
HISTORIES OF OUR FAMILIES TO 

3527
02:13:02,663 --> 02:13:03,697
EXPLORE ASSOCIATIONS.

3528
02:13:03,697 --> 02:13:05,699
THE PROOF IN THAT IS SEEING WHAT

3529
02:13:05,699 --> 02:13:07,534
YOU ARE GOING TO HEAR ABOUT 

3530
02:13:07,534 --> 02:13:09,903
LATER TODAY IN TERMS OF ABCD, 

3531
02:13:09,903 --> 02:13:11,905
WHAT THEY HAVE ACCOMPLISHED TO 

3532
02:13:11,905 --> 02:13:13,540
PIECE TOGETHER A REALLY BROAD 

3533
02:13:13,540 --> 02:13:18,312
RICH DATA SET TO HAVE REALLY 

3534
02:13:18,312 --> 02:13:21,415
IMPORTANT HIGHLY IMPACTFUL 

3535
02:13:21,415 --> 02:13:23,083
FINDINGS THAT RELATE AMONG 

3536
02:13:23,083 --> 02:13:23,317
DOMAINS.

3537
02:13:23,317 --> 02:13:26,053
WE HOPE TO REPLICATE THAT AND 

3538
02:13:26,053 --> 02:13:26,954
FOLLOW IN THEIR PATH.

3539
02:13:26,954 --> 02:13:29,156
>> SO BELIEVE IT OR NOT,
WE ARE 

3540
02:13:29,156 --> 02:13:29,523
ON TIME.

3541
02:13:29,523 --> 02:13:36,196
SO WE WILL RECONVENE AT 12:40 

3542
02:13:36,196 --> 02:13:37,698
P.M. EAST COAST TIME AND NORA 

3543
02:13:37,698 --> 02:13:39,466
WILL BE TAKING OVER AT THAT 

3544
02:13:39,466 --> 02:13:40,033
POINT.

3545
02:13:40,033 --> 02:13:43,403
JUST TO REMIND YOU, NORA.

3546
02:13:43,403 --> 02:13:45,605
YOU ARE THE FEARLESS LEADER 

3547
02:13:45,605 --> 02:13:46,506
STARTING AT 12:40.

3548
02:13:46,506 --> 02:13:47,874
>> SOUNDS GOOD.

3549
02:13:47,874 --> 02:13:48,621
>> THANKS, EVERYBODY.

3550
02:13:48,621 --> 02:13:49,622
>> THANKS, BYE.

3551
02:13:49,622 --> 02:13:50,199
GOOD AFTERNOON, EVERYONE.

3552
02:13:50,199 --> 02:13:51,901
THANKS FOR YOUR PARTICIPATION.

3553
02:13:51,901 --> 02:13:54,137
AND NOW WE ARE GOING TO GO TO 

3554
02:13:54,137 --> 02:13:57,941
THE TOPIC IN THE AGENDA OF THE 

3555
02:13:57,941 --> 02:14:00,877
ABCD AND IT'S A PLEASURE FOR ME 

3556
02:14:00,877 --> 02:14:03,947
TO ACTUALLY INTRODUCE DR. GAYA 

3557
02:14:03,947 --> 02:14:06,149
DOWLING, DR. TRACI MURRAY AND 

3558
02:14:06,149 --> 02:14:08,184
DR. DIANA ALKIRE.

3559
02:14:08,184 --> 02:14:09,886
WE ARE GOING TO GIVE AN UPDATE 

3560
02:14:09,886 --> 02:14:12,822
OVER THE PAST YEAR SINCE THEY 

3561
02:14:12,822 --> 02:14:14,757
LAST GAVE A PRESENTATION AT 

3562
02:14:14,757 --> 02:14:14,958
CRAN.

3563
02:14:14,958 --> 02:14:17,427
FOR THOSE OF YOU THAT DO NOT 

3564
02:14:17,427 --> 02:14:19,929
KNOW DR. DOWLING, SHE IS THE 

3565
02:14:19,929 --> 02:14:21,898
DIRECTOR OF THE ABCD STUDY.

3566
02:14:21,898 --> 02:14:25,201
FOR THOSE WHO DO NOT KNOW, DR. 

3567
02:14:25,201 --> 02:14:29,739
MURRAY, IS A SCIENTIFIC ADVISER 

3568
02:14:29,739 --> 02:14:32,642
FOR THE ABCD AND HBCD.

3569
02:14:32,642 --> 02:14:35,545
AND DR. ALKIRE IS A PROGRAM 

3570
02:14:35,545 --> 02:14:35,945
ANALYST.

3571
02:14:35,945 --> 02:14:41,217
SO GAYA, PLEASE JUMP IN.

3572
02:14:41,217 --> 02:14:44,220
>> THANK YOU, NORA.

3573
02:14:44,220 --> 02:14:45,722
AND THANK YOU EVERYBODY FOR AN 

3574
02:14:45,722 --> 02:14:47,757
OPPORTUNITY AGAIN TO GIVE YOU AN

3575
02:14:47,757 --> 02:14:50,927
UPDATE ON THE ABCD STUDY.

3576
02:14:50,927 --> 02:14:57,800
AS NORA MENTIONED -- IT DOESN'T 

3577
02:14:57,800 --> 02:15:08,211
SEEM TO WANT TO ADVANCE.

3578
02:15:11,748 --> 02:15:13,850
I'M GOING TO GIVE YOU A BRIEF 

3579
02:15:13,850 --> 02:15:15,518
UPDATE ON HOW THINGS HAVE BEEN 

3580
02:15:15,518 --> 02:15:16,886
GOING IN ABCD.

3581
02:15:16,886 --> 02:15:18,921
BUT I REALLY WANT TO SPEND MOST 

3582
02:15:18,921 --> 02:15:21,824
OF THE TIME WITH DIANA 

3583
02:15:21,824 --> 02:15:23,326
ELABORATING ON WHAT NORA TALKED 

3584
02:15:23,326 --> 02:15:25,995
ABOUT YESTERDAY IN TERMS OF THE 

3585
02:15:25,995 --> 02:15:29,132
STUDY IMPACT AND TRACI TO GIVE 

3586
02:15:29,132 --> 02:15:32,535
AN UPDATE ON A FINDING OF WHY WE

3587
02:15:32,535 --> 02:15:34,337
STARTED ABCD TO BEGIN WITH.

3588
02:15:34,337 --> 02:15:36,105
MOST OF YOU HAVE HEARD ME TALK 

3589
02:15:36,105 --> 02:15:38,641
ABOUT ABCD FOR A VERY LONG TIME,

3590
02:15:38,641 --> 02:15:40,143
SO I'M NOT GOING TO SPEND A LOT 

3591
02:15:40,143 --> 02:15:42,879
OF TIME DESCRIBING THE STUDY.

3592
02:15:42,879 --> 02:15:45,048
SINCE THERE WERE A FEW NEW 

3593
02:15:45,048 --> 02:15:47,150
FACES, I THOUGHT I WOULD START 

3594
02:15:47,150 --> 02:15:49,919
GIVING A HIGH-LEVEL OVERVIEW.

3595
02:15:49,919 --> 02:15:54,390
A LONGITUDAL STUDY OF 12,000 

3596
02:15:54,390 --> 02:15:56,492
KIDS, TWINS AND TRIPLETS.

3597
02:15:56,492 --> 02:15:59,796
WE STARTED WHEN THEY WERE 9 OR 

3598
02:15:59,796 --> 02:16:02,598
10 YEARS OLD IN 2016 AND HAVE 

3599
02:16:02,598 --> 02:16:04,133
BEEN FOLLOWING THEM EVER SINCE 

3600
02:16:04,133 --> 02:16:06,035
AND LOOKING AT MANY DIFFERENT 

3601
02:16:06,035 --> 02:16:06,736
FACTORS THAT INFLUENCE 

3602
02:16:06,736 --> 02:16:07,637
DEVELOPMENT.

3603
02:16:07,637 --> 02:16:10,907
AT THE UPPER RIGHT WE HAVE 

3604
02:16:10,907 --> 02:16:12,508
MEASURES COVERING PHYSICAL 

3605
02:16:12,508 --> 02:16:13,443
HEALTH, MENTAL HEALTH, SUBS 

3606
02:16:13,443 --> 02:16:18,848
STANCE USE,  -- SUBSTANCE USE, 

3607
02:16:18,848 --> 02:16:19,982
ENVIRONMENT, FAMILY.

3608
02:16:19,982 --> 02:16:22,418
WE CHECK BIOSPECIMENS.

3609
02:16:22,418 --> 02:16:24,987
WE HAVE SOME DATA FROM FIT BITS 

3610
02:16:24,987 --> 02:16:26,923
AND A CELL PHONE APP THAT 

3611
02:16:26,923 --> 02:16:28,191
MONITORS TO GET US SOME 

3612
02:16:28,191 --> 02:16:31,728
OBJECTIVE MEASURES OF ACTIVITY 

3613
02:16:31,728 --> 02:16:34,030
IN CELL PHONE USE.

3614
02:16:34,030 --> 02:16:37,066
GEOCODED DATA SIMILAR TO WHAT 

3615
02:16:37,066 --> 02:16:41,070
CHRIS DESCRIBED FOR HBCD SO WE 

3616
02:16:41,070 --> 02:16:42,805
CAN LINK RESIDENTIAL HISTORIES 

3617
02:16:42,805 --> 02:16:45,475
TO MANY DATA BASES TO GIVE A 

3618
02:16:45,475 --> 02:16:47,076
BETTER PICTURE OF THE 

3619
02:16:47,076 --> 02:16:49,946
ENVIRONMENT IN WHICH THE YOUTH 

3620
02:16:49,946 --> 02:16:50,146
LIVED.

3621
02:16:50,146 --> 02:16:52,715
COVID HIT RIGHT IN THE MIDDLE OF

3622
02:16:52,715 --> 02:16:55,685
ABCD, WE HAVE SOME DATA ON THE 

3623
02:16:55,685 --> 02:16:57,320
EXPERIENCES YOUTH HAD DURING THE

3624
02:16:57,320 --> 02:17:00,289
ACUTE PHASE OF THE PANDEMIC.

3625
02:17:00,289 --> 02:17:03,826
WE WERE PART OF THE NI FOR COVER

3626
02:17:03,826 --> 02:17:05,895
INITIATIVE, SO WE WILL HAVE DATA

3627
02:17:05,895 --> 02:17:10,199
ON LONG COVID SYMPTOMS AND 

3628
02:17:10,199 --> 02:17:11,167
ANTIBODY DATA ON INFECTION 

3629
02:17:11,167 --> 02:17:12,668
COMING DOWN THE PIKE.

3630
02:17:12,668 --> 02:17:14,837
THE FIGURE AT THE BOTTOM RIGHT 

3631
02:17:14,837 --> 02:17:16,439
REALLY JUST SHOWS THE SEQUENCE 

3632
02:17:16,439 --> 02:17:17,507
OF EVENTS.

3633
02:17:17,507 --> 02:17:19,308
WE DO THE NEUROIMAGING EVERY 

3634
02:17:19,308 --> 02:17:20,143
OTHER YEAR.

3635
02:17:20,143 --> 02:17:22,545
THAT VISIT IS FAIRLY LONG, SEVEN

3636
02:17:22,545 --> 02:17:24,747
TO EIGHT HOURS WHERE WE COLLECT 

3637
02:17:24,747 --> 02:17:26,582
ALL OF THE INFORMATION I JUST 

3638
02:17:26,582 --> 02:17:26,916
MENTIONED.

3639
02:17:26,916 --> 02:17:30,153
AND IN THE INTERVENING YEAR 

3640
02:17:30,153 --> 02:17:34,891
THERE IS NO IMAGING OR FEWER 

3641
02:17:34,891 --> 02:17:36,359
BIOSPECIMENS AND COGNITIVE 

3642
02:17:36,359 --> 02:17:36,559
TESTS.

3643
02:17:36,559 --> 02:17:38,928
BUT WE CONTINUE TO DO THE 

3644
02:17:38,928 --> 02:17:39,295
QUESTIONNAIRES.

3645
02:17:39,295 --> 02:17:40,696
IT HAS BEEN REPEATING.

3646
02:17:40,696 --> 02:17:43,666
SO HERE YOU CAN SEE WE STARTED 

3647
02:17:43,666 --> 02:17:45,201
THE END OF 2016.

3648
02:17:45,201 --> 02:17:46,736
AND IN THE YELLOW IS WHERE WE 

3649
02:17:46,736 --> 02:17:50,940
WILL BE THIS FALL.

3650
02:17:50,940 --> 02:17:52,742
SO WE'RE NOW COLLECTING OUR 

3651
02:17:52,742 --> 02:17:54,143
NINTH WAVE OF DATA.

3652
02:17:54,143 --> 02:17:56,212
AND WHEN WE START IN THE FALL, 

3653
02:17:56,212 --> 02:17:58,648
MOST OF OUR PARTICIPANTS WILL BE

3654
02:17:58,648 --> 02:17:59,749
TURNING 18.

3655
02:17:59,749 --> 02:18:04,153
SO REALLY WE HAVE COVERED THIS 

3656
02:18:04,153 --> 02:18:09,792
SCOPE FROM 9 TO 18.

3657
02:18:09,792 --> 02:18:11,561
AS NORA MENTIONED YESTERDAY, WE 

3658
02:18:11,561 --> 02:18:14,964
ARE PROUD WE HAVE RETAINED 95% 

3659
02:18:14,964 --> 02:18:16,432
OF THE PARTICIPANTS.

3660
02:18:16,432 --> 02:18:19,035
WHEN WE TALK ABOUT RETENTION IN 

3661
02:18:19,035 --> 02:18:20,536
ABCD, ONLY 5% HAVE OFFICIALLY 

3662
02:18:20,536 --> 02:18:22,905
WITHDRAWN FROM THE STUDY.

3663
02:18:22,905 --> 02:18:24,373
WE DON'T CONSIDER SOMEBODY 

3664
02:18:24,373 --> 02:18:25,174
WITHDRAWN UNTIL THEY TELL US 

3665
02:18:25,174 --> 02:18:26,776
THEY DON'T WANT TO BE CONTACTED 

3666
02:18:26,776 --> 02:18:28,010
ANYMORE BECAUSE WE WANT TO GIVE 

3667
02:18:28,010 --> 02:18:29,345
THEM THE OPPORTUNITY TO COME 

3668
02:18:29,345 --> 02:18:30,980
BACK EVEN IF THEY HAVE MISSED 

3669
02:18:30,980 --> 02:18:33,115
SOME VISITS.

3670
02:18:33,115 --> 02:18:34,717
SO THIS FIGURE SHOWS YOU A 

3671
02:18:34,717 --> 02:18:36,552
LITTLE BIT ABOUT WHERE WE ARE.

3672
02:18:36,552 --> 02:18:41,090
IT HAS KCURVES FOR THE VISIT 

3673
02:18:41,090 --> 02:18:43,526
COMPLETION AT THE VARIOUS 

3674
02:18:43,526 --> 02:18:45,728
VISITS.

3675
02:18:45,728 --> 02:18:51,434
ANNUAL VISIT FROM BASELINE TO 

3676
02:18:51,434 --> 02:18:52,969
EIGHT-YEAR FOLLOW-UP WHICH BEGAN

3677
02:18:52,969 --> 02:18:53,870
LAST FALL.

3678
02:18:53,870 --> 02:18:55,905
THE TWO-YEAR FOLLOW UP, THE 

3679
02:18:55,905 --> 02:18:58,641
THIRD LINE FROM THE LEFT, THE 

3680
02:18:58,641 --> 02:19:00,643
FLATTENING, THAT IS WHEN COVID 

3681
02:19:00,643 --> 02:19:00,943
HIT.

3682
02:19:00,943 --> 02:19:03,012
ABCD HAS BEEN TRYING TO RECOVER 

3683
02:19:03,012 --> 02:19:04,714
FROM COVID FOR THE LAST FEW 

3684
02:19:04,714 --> 02:19:04,914
YEARS.

3685
02:19:04,914 --> 02:19:06,916
WE HAD TO CLOSE DOWN.

3686
02:19:06,916 --> 02:19:08,718
WE REOPENED.

3687
02:19:08,718 --> 02:19:10,753
BUT IT CAUSED US TO KIND OF 

3688
02:19:10,753 --> 02:19:12,221
SHIFT THINGS OVER A LITTLE BIT, 

3689
02:19:12,221 --> 02:19:16,125
SO DELAYS IN STARTING THE FOUR 

3690
02:19:16,125 --> 02:19:16,325
YEAR.

3691
02:19:16,325 --> 02:19:19,795
AND IN THE FIVE YEAR, WE REALLY 

3692
02:19:19,795 --> 02:19:21,464
ASKED SITES TO COME UP WITH A 

3693
02:19:21,464 --> 02:19:23,766
PLAN TO GET BACK ON TRACK SO WE 

3694
02:19:23,766 --> 02:19:25,134
COULD GET EVERYBODY BACK IN, AT 

3695
02:19:25,134 --> 02:19:27,203
LEAST BY THE EIGHT-YEAR 

3696
02:19:27,203 --> 02:19:27,470
FOLLOW-UP.

3697
02:19:27,470 --> 02:19:29,171
IN THE SIX YEAR WE ARE STARTING 

3698
02:19:29,171 --> 02:19:31,607
TO GET THOSE NUMBERS BACK UP AND

3699
02:19:31,607 --> 02:19:33,776
WE'RE ON TRACK FOR THE SEVEN AND

3700
02:19:33,776 --> 02:19:35,912
EIGHT YEAR TO GET US BACK TO THE

3701
02:19:35,912 --> 02:19:38,314
LEVELS WHERE WE BEGAN.

3702
02:19:38,314 --> 02:19:40,683
THE OTHER CHALLENGE WITH COVID 

3703
02:19:40,683 --> 02:19:42,919
WAS THAT WE TRANSITIONED TO 

3704
02:19:42,919 --> 02:19:45,888
DOING MOST OF THE PROTOCOL 

3705
02:19:45,888 --> 02:19:46,155
REMOTELY.

3706
02:19:46,155 --> 02:19:48,791
WHICH WAS JUST A NECESSITY FOR 

3707
02:19:48,791 --> 02:19:50,660
THE THREE-YEAR FOLLOW-UP, WHICH 

3708
02:19:50,660 --> 02:19:52,561
WAS NOT AN IMAGING YEAR.

3709
02:19:52,561 --> 02:19:55,298
IT HAS TAKEN US SOME TIME TO GET

3710
02:19:55,298 --> 02:19:57,466
BACK TO DOING MOSTLY IN-PERSON 

3711
02:19:57,466 --> 02:19:59,936
OR HYBRID VISITS.

3712
02:19:59,936 --> 02:20:02,838
THE HYBRID VISITS, WE DO 

3713
02:20:02,838 --> 02:20:03,839
QUESTIONNAIRES REMOTELY AND COME

3714
02:20:03,839 --> 02:20:08,878
IN FOR IMAGING, BIOSPECIMENS AND

3715
02:20:08,878 --> 02:20:09,912
COGNITIVE TASKS.

3716
02:20:09,912 --> 02:20:11,714
THOSE WHO DID IT REMOTELY 

3717
02:20:11,714 --> 02:20:14,116
WEREN'T EXCITED TO COME BACK AND

3718
02:20:14,116 --> 02:20:15,551
SPEND WHOLE DAYS IN THE SITE.

3719
02:20:15,551 --> 02:20:18,955
IT WAS A CONCERTED EFFORT BY THE

3720
02:20:18,955 --> 02:20:20,957
RAs AT THE SITE TO BRING THEM IN

3721
02:20:20,957 --> 02:20:22,391
PERSON SO WE WOULDN'T LOSE THAT 

3722
02:20:22,391 --> 02:20:23,092
MUCH DATA.

3723
02:20:23,092 --> 02:20:25,328
AS I MENTIONED, WHEN WE TALK 

3724
02:20:25,328 --> 02:20:27,830
ABOUT RETENTION, WE ARE TALKING 

3725
02:20:27,830 --> 02:20:29,065
ABOUT NOT HAVING WITHDRAWN, BUT 

3726
02:20:29,065 --> 02:20:30,900
WE HAVE PARTICIPANTS THAT HAVE 

3727
02:20:30,900 --> 02:20:32,134
MISSED VISITS.

3728
02:20:32,134 --> 02:20:34,337
I LIKE THIS FIGURE BECAUSE IT 

3729
02:20:34,337 --> 02:20:37,473
SHOWS US KIND OF THE PATTERNS OF

3730
02:20:37,473 --> 02:20:38,407
THAT MISSING VISITS.

3731
02:20:38,407 --> 02:20:40,977
IN THE BLUE ARE COMPLETED 

3732
02:20:40,977 --> 02:20:42,144
VISITS.

3733
02:20:42,144 --> 02:20:45,081
ACROSS THE X AXIS YOU HAVE THE 

3734
02:20:45,081 --> 02:20:45,314
VISITS.

3735
02:20:45,314 --> 02:20:47,917
FOR MOST PART PEOPLE ARE 

3736
02:20:47,917 --> 02:20:49,018
COMPLETELY VISITS.

3737
02:20:49,018 --> 02:20:50,386
PEOPLE MISSING VISITS WHICH YOU 

3738
02:20:50,386 --> 02:20:52,788
SEE IN THE RED, SOME COME BACK 

3739
02:20:52,788 --> 02:20:54,490
FOR A SUBSEQUENT VISIT.

3740
02:20:54,490 --> 02:20:55,858
SO THE IDEA WE AREN'T 

3741
02:20:55,858 --> 02:20:56,759
CONSIDERING THEM WITHDRAWN IS TO

3742
02:20:56,759 --> 02:20:58,928
MAKE SURE THAT HAPPENS.

3743
02:20:58,928 --> 02:21:01,597
THAT PEOPLE COME BACK EVEN IF 

3744
02:21:01,597 --> 02:21:04,533
THEY HAVE MISSED ONE, TWO, 

3745
02:21:04,533 --> 02:21:08,804
SOMETIMES FOUR VISITS.

3746
02:21:08,804 --> 02:21:10,940
I THOUGHT IT WAS INTERESTING TO 

3747
02:21:10,940 --> 02:21:15,211
TAKE A LOOK AT HOW MANY 

3748
02:21:15,211 --> 02:21:18,848
PARTICIPANTS NEVER MISSED A 

3749
02:21:18,848 --> 02:21:19,248
VISIT.

3750
02:21:19,248 --> 02:21:21,350
MORE THAN 7,000 HAVE NOT MISSED.

3751
02:21:21,350 --> 02:21:23,252
A NUMBER THAT MISSED TWO OR 

3752
02:21:23,252 --> 02:21:24,920
FEWER, WE ARE AT MORE THAN 

3753
02:21:24,920 --> 02:21:25,154
10,000.

3754
02:21:25,154 --> 02:21:27,156
SO WE ARE KEEPING THE COHORT 

3755
02:21:27,156 --> 02:21:30,593
TOGETHER, WHICH IS REALLY 

3756
02:21:30,593 --> 02:21:30,860
EXCITING.

3757
02:21:30,860 --> 02:21:33,195
I ALSO WANT TO TALK A LITTLE BIT

3758
02:21:33,195 --> 02:21:34,930
ABOUT THE IMAGING BECAUSE THIS 

3759
02:21:34,930 --> 02:21:36,932
TOOK A BIT OF A HIT DURING COVID

3760
02:21:36,932 --> 02:21:37,600
AS WELL.

3761
02:21:37,600 --> 02:21:39,902
YOU CAN SEE HERE AT THE 

3762
02:21:39,902 --> 02:21:41,570
TWO-YEAR -- SO COVID HIT IN THE 

3763
02:21:41,570 --> 02:21:42,938
MIDDLE OF THE TWO-YEAR 

3764
02:21:42,938 --> 02:21:43,339
FOLLOW-UP.

3765
02:21:43,339 --> 02:21:44,907
SO OUR NUMBERS DROPPED FROM 

3766
02:21:44,907 --> 02:21:47,243
BASELINE TO THE TWO-YEAR 

3767
02:21:47,243 --> 02:21:49,612
FOLLOW-UP AND MORE SO IN THE 

3768
02:21:49,612 --> 02:21:50,446
FOUR-YEAR FOLLOW-UP AS WE WERE 

3769
02:21:50,446 --> 02:21:51,947
COMING OUT OF THE PANDEMIC.

3770
02:21:51,947 --> 02:21:54,250
THE SIX-YEAR FOLLOW-UP IS 

3771
02:21:54,250 --> 02:21:56,152
STARTING TO REBOUND AND WE'VE 

3772
02:21:56,152 --> 02:21:58,020
JUST BEGIN THE EIGHT-YEAR 

3773
02:21:58,020 --> 02:22:00,256
FOLLOW-UP IN THE FALL SO WE ARE 

3774
02:22:00,256 --> 02:22:01,457
ONLY 18%.

3775
02:22:01,457 --> 02:22:02,925
HOPEFULLY THAT NUMBER -- AND THE

3776
02:22:02,925 --> 02:22:04,727
SITES ARE REALLY FOCUSING ON 

3777
02:22:04,727 --> 02:22:06,328
THIS EIGHT-YEAR FOLLOW-UP.

3778
02:22:06,328 --> 02:22:07,797
THEY ARE DOING BOTH THE SEVEN 

3779
02:22:07,797 --> 02:22:09,231
AND EIGHT YEAR RIGHT NOW.

3780
02:22:09,231 --> 02:22:10,900
BECAUSE THE EIGHT YEAR FOLLOW-UP

3781
02:22:10,900 --> 02:22:13,135
IS A NEUROIMAGING VISIT, A LOT 

3782
02:22:13,135 --> 02:22:14,470
OF THE EFFORT IS BEING 

3783
02:22:14,470 --> 02:22:16,272
CONCENTRATED TO MAKE SURE WE CAN

3784
02:22:16,272 --> 02:22:17,940
GET THAT LAST IMAGING VISIT.

3785
02:22:17,940 --> 02:22:20,476
SO I ALSO WANTED TO TAKE A LOOK 

3786
02:22:20,476 --> 02:22:22,945
AT HOW MANY PARTICIPANTS DO WE 

3787
02:22:22,945 --> 02:22:25,848
HAVE THAT WE ARE HAVING 

3788
02:22:25,848 --> 02:22:28,384
COMPLETED AT LEAST T1 IN IMAGING

3789
02:22:28,384 --> 02:22:28,851
PROTOCOL.

3790
02:22:28,851 --> 02:22:36,292
NEARLY 3,800 HAVE COMPLETED THE 

3791
02:22:36,292 --> 02:22:39,061
1s IN FOUR IMAGING VISITS.

3792
02:22:39,061 --> 02:22:40,629
THE FIFTH IS JUST STARTING SO WE

3793
02:22:40,629 --> 02:22:42,731
DON'T HAVE THAT MANY IN THAT 

3794
02:22:42,731 --> 02:22:42,998
CATEGORY.

3795
02:22:42,998 --> 02:22:44,700
IF YOU LOOK AT THE NUMBER WITH 

3796
02:22:44,700 --> 02:22:47,736
THREE IMAGING VISITS IS NEARLY 

3797
02:22:47,736 --> 02:22:47,937
8,000.

3798
02:22:47,937 --> 02:22:48,838
DESPITE THE STRUGGLES WE HAVE 

3799
02:22:48,838 --> 02:22:53,375
HAD IN TERMS OF OVERCOMING 

3800
02:22:53,375 --> 02:22:58,347
COVID, WE HAVE LONGITUDINAL 

3801
02:22:58,347 --> 02:23:00,516
IMAGING DATA ON A LARGE SUBSET 

3802
02:23:00,516 --> 02:23:01,484
OF THE POPULATION.

3803
02:23:01,484 --> 02:23:03,219
I WANTED TO COME BACK HERE AND 

3804
02:23:03,219 --> 02:23:05,187
JUST TO POINT OUT THAT THE KIDS 

3805
02:23:05,187 --> 02:23:07,656
ARE NOW ALMOST 18 YEARS OLD.

3806
02:23:07,656 --> 02:23:09,558
SOME OF THEM ARE ALREADY 18 

3807
02:23:09,558 --> 02:23:11,127
YEARS OLD AND WE ARE COMING ON 

3808
02:23:11,127 --> 02:23:15,397
THE LAST, THE 10th VISIT FROM 

3809
02:23:15,397 --> 02:23:19,735
OUR SO-YEAR STUDY, BUT WE KNOW 

3810
02:23:19,735 --> 02:23:21,403
THAT THE OUTCOMES WE ARE 

3811
02:23:21,403 --> 02:23:23,506
INTERESTED IN, BRAIN 

3812
02:23:23,506 --> 02:23:25,241
DEVELOPMENT, SUBSTANCE USE, 

3813
02:23:25,241 --> 02:23:25,908
MENTAL HEALTH, WE HAVEN'T SEEN 

3814
02:23:25,908 --> 02:23:27,376
THEM YET.

3815
02:23:27,376 --> 02:23:29,712
WE ARE JUST STARTING TO SEE 

3816
02:23:29,712 --> 02:23:31,547
SIGNIFICANT SUBSTANCE USE.

3817
02:23:31,547 --> 02:23:33,582
WE KNOW THE BRAIN IS CONTINUING 

3818
02:23:33,582 --> 02:23:34,550
TO DEVELOP.

3819
02:23:34,550 --> 02:23:36,519
SO WE KNOW WE NEED TO CONTINUE 

3820
02:23:36,519 --> 02:23:38,787
TO FOLLOW THESE YOUTH AT LEAST 

3821
02:23:38,787 --> 02:23:40,122
THROUGH THEIR EARLY 20s TO LOOK 

3822
02:23:40,122 --> 02:23:41,991
AT WHAT NORA AND GEORGE HAVE 

3823
02:23:41,991 --> 02:23:44,193
BEEN TALKING ABOUT IN TERMS OF 

3824
02:23:44,193 --> 02:23:45,928
THE FACTORS THAT MIGHT PREDICT 

3825
02:23:45,928 --> 02:23:49,465
SUBSTANCE USE, A TRANSITION TO 

3826
02:23:49,465 --> 02:23:50,399
SUBSTANCE USE DISORDERS.

3827
02:23:50,399 --> 02:23:52,001
WE CAN'T STOP NOW.

3828
02:23:52,001 --> 02:23:54,270
TRACI MURRAY AT THE END OF HER 

3829
02:23:54,270 --> 02:23:55,404
TALK WILL GIVE YOU INSIGHT OF 

3830
02:23:55,404 --> 02:23:58,040
HOW WE ARE THINKING ABOUT 

3831
02:23:58,040 --> 02:23:58,908
PLANNING FOR THE FUTURE.

3832
02:23:58,908 --> 02:24:03,179
I WANT TO PUT A PLUG IN FOR ABCD

3833
02:24:03,179 --> 02:24:05,080
INSIGHTS AND INNOVATION MEETING.

3834
02:24:05,080 --> 02:24:08,150
LAST YEAR WE HELD THE INAUGURAL 

3835
02:24:08,150 --> 02:24:09,652
AIM AND IT WAS VERY EXCITING.

3836
02:24:09,652 --> 02:24:11,954
IT WAS THE FIRST MEETING WE WERE

3837
02:24:11,954 --> 02:24:14,190
ABLE TO BRING TOGETHER PEOPLE 

3838
02:24:14,190 --> 02:24:16,258
USING ABCD DATA IN DIFFERENT 

3839
02:24:16,258 --> 02:24:16,458
WAYS.

3840
02:24:16,458 --> 02:24:19,595
WE'VE GOT SO MUCH DATA THERE IS 

3841
02:24:19,595 --> 02:24:22,031
A BROAD ARRAY OF SCIENCE COMING 

3842
02:24:22,031 --> 02:24:26,735
OUT OF ABCD AND WANTED TO BRING 

3843
02:24:26,735 --> 02:24:27,903
IT ALL IN ONE PLACE.

3844
02:24:27,903 --> 02:24:29,438
WE DID THAT LAST YEAR.

3845
02:24:29,438 --> 02:24:32,074
BECAUSE OF THE CURRENT EVENTS, 

3846
02:24:32,074 --> 02:24:33,842
WE HAD TO POSTPONE THIS YEAR AND

3847
02:24:33,842 --> 02:24:35,611
SCALE BACK A LITTLE BIT ON THE 

3848
02:24:35,611 --> 02:24:36,779
MEETING.

3849
02:24:36,779 --> 02:24:38,914
BUT WE WANTED TO MAKE SURE WE AT

3850
02:24:38,914 --> 02:24:40,015
LEAST DID SOMETHING.

3851
02:24:40,015 --> 02:24:41,650
ONE OF THE MOST EXCITING PARTS 

3852
02:24:41,650 --> 02:24:43,619
OF THE MEETING LAST YEAR IS WE 

3853
02:24:43,619 --> 02:24:45,387
PROVIDED AN OPPORTUNITY, 

3854
02:24:45,387 --> 02:24:49,425
PARTICULARLY TO TRAINEES TO MEET

3855
02:24:49,425 --> 02:24:50,893
WITH ABCD EXPERTS AND ASK 

3856
02:24:50,893 --> 02:24:51,527
QUESTIONS.

3857
02:24:51,527 --> 02:24:53,162
PEOPLE USING THE DATA, NEW TO 

3858
02:24:53,162 --> 02:24:54,897
USING THE DATA, BEING ABLE TO 

3859
02:24:54,897 --> 02:24:56,265
GET THEIR QUESTIONS ANSWERED TO 

3860
02:24:56,265 --> 02:24:57,499
UNDERSTAND HOW BETTER TO USE THE

3861
02:24:57,499 --> 02:24:57,967
DATA.

3862
02:24:57,967 --> 02:24:59,868
WE WANTED TO REPLICATE THAT.

3863
02:24:59,868 --> 02:25:01,437
SO WE ARE DOING THAT PORTION.

3864
02:25:01,437 --> 02:25:04,573
SO WE HAVE IN-PERSON MEETING 

3865
02:25:04,573 --> 02:25:07,076
THAT IS A LITTLE BIT SMALLER, 

3866
02:25:07,076 --> 02:25:09,745
BUT FOCUSING IN ON THESE 

3867
02:25:09,745 --> 02:25:10,012
WORKSHOPS.

3868
02:25:10,012 --> 02:25:11,280
ELIZABETH WILL TALK ABOUT THE 

3869
02:25:11,280 --> 02:25:13,215
NEW DATA SHARING PLATFORM, GIVEN

3870
02:25:13,215 --> 02:25:15,951
THAT IS JUST COMING OUT, WE WANT

3871
02:25:15,951 --> 02:25:17,653
TO INTRODUCE THAT TO FOLKS, 

3872
02:25:17,653 --> 02:25:20,623
ANSWER QUESTIONS ON HOW TO USE 

3873
02:25:20,623 --> 02:25:20,823
IT.

3874
02:25:20,823 --> 02:25:23,993
A NEW DATA EXPLORATION AND 

3875
02:25:23,993 --> 02:25:24,793
ANALYSIS PORTAL.

3876
02:25:24,793 --> 02:25:26,996
SOME NEW IMAGING TOOLS.

3877
02:25:26,996 --> 02:25:29,632
WORKSHOP ON HOW TO USE THE 

3878
02:25:29,632 --> 02:25:32,501
LINKED EXTERNAL DATA AND NOW WE 

3879
02:25:32,501 --> 02:25:35,871
HAVE LONGITUDINAL DATA HOW TO 

3880
02:25:35,871 --> 02:25:37,740
INCORPORATE LONGITUDE NAT DATA 

3881
02:25:37,740 --> 02:25:39,541
IN YOUR ANALYSES.

3882
02:25:39,541 --> 02:25:45,914
IF YOU HAVE TRAINEES INTERESTED,

3883
02:25:45,914 --> 02:25:50,019
REGISTER AT 

3884
02:25:50,019 --> 02:25:50,486
ABCDSTUDY.ORG/MEETING.

3885
02:25:50,486 --> 02:25:52,554
IT IS ONLY IN PERSON.

3886
02:25:52,554 --> 02:25:54,423
WHICH IS WHAT WE WANT TO GET OUT

3887
02:25:54,423 --> 02:25:56,792
OF IT, HANDS ON EXPERIENCE.

3888
02:25:56,792 --> 02:26:00,663
WE WILL FOCUS ON MENTORSHIPS.

3889
02:26:00,663 --> 02:26:03,499
WE PAIRED INVESTIGATOR TRAINEES 

3890
02:26:03,499 --> 02:26:06,235
WITH NIH POs SO THEY COULD GET 

3891
02:26:06,235 --> 02:26:09,038
SOME MORE HANDS-ON EXPERIENCE.

3892
02:26:09,038 --> 02:26:10,973
AND THEN THE LAST THING BEFORE I

3893
02:26:10,973 --> 02:26:12,941
TURN THIS OVER IS I WANT TO 

3894
02:26:12,941 --> 02:26:15,144
ANNOUNCE THAT ABCD IS NOW 

3895
02:26:15,144 --> 02:26:17,146
SOCIAL.

3896
02:26:17,146 --> 02:26:20,249
SO WE HAVE INSTAGRAM ACCOUNTS, 

3897
02:26:20,249 --> 02:26:23,319
FACEBOOK, YOUTUBE, TWITTER, 

3898
02:26:23,319 --> 02:26:25,220
BLUESKY, YOU NAME IT.

3899
02:26:25,220 --> 02:26:27,389
FOLLOW US ON WHICHEVER OF THESE 

3900
02:26:27,389 --> 02:26:28,557
PLATFORMS YOU ARE USING AND 

3901
02:26:28,557 --> 02:26:30,759
YOU'LL BE ABLE TO SEE UPDATES, 

3902
02:26:30,759 --> 02:26:32,861
YOU'LL BE ABLE TO SEE THINGS 

3903
02:26:32,861 --> 02:26:34,930
GOING ON AT THE VARIOUS SITES.

3904
02:26:34,930 --> 02:26:38,801
WHEN WE HAVE INFOGRAPHICS WE 

3905
02:26:38,801 --> 02:26:39,401
WILL SHOWCASE THEM.

3906
02:26:39,401 --> 02:26:41,437
IT IS A GREAT WAY TO STAY UP 

3907
02:26:41,437 --> 02:26:42,905
WITH WHAT IS HAPPENING IN ABCD.

3908
02:26:42,905 --> 02:26:44,473
WITH THAT, I WILL TURN IT OVER 

3909
02:26:44,473 --> 02:26:47,176
TO DIANA TO TALK ABOUT WHAT WE 

3910
02:26:47,176 --> 02:26:50,579
HAVE SEEN IN TERMS OF IMPACT OF 

3911
02:26:50,579 --> 02:26:52,348
THE STUDY OVER THESE LAST 10 

3912
02:26:52,348 --> 02:26:53,182
YEARS.

3913
02:26:53,182 --> 02:26:54,083
DIANA, ARE YOU THERE?

3914
02:26:54,083 --> 02:26:54,616
>> YEAH.

3915
02:26:54,616 --> 02:26:56,752
CAN YOU HEAR ME?

3916
02:26:56,752 --> 02:26:57,419
>> YES.

3917
02:26:57,419 --> 02:27:05,828
>> HELLO, EVERYONE.

3918
02:27:05,828 --> 02:27:08,564
NIH FUNDERS INCLUDE 15 

3919
02:27:08,564 --> 02:27:13,302
INSTITUTES SHOWING THE STUDY'S 

3920
02:27:13,302 --> 02:27:15,337
VALUE EXTENDED BEYOND WHAT WAS 

3921
02:27:15,337 --> 02:27:16,138
ORIGINALLY CONCEIVED.

3922
02:27:16,138 --> 02:27:23,278
NEXT SLIDE.

3923
02:27:23,278 --> 02:27:24,346
THE ABCD DATA -- 

3924
02:27:24,346 --> 02:27:25,881
>> DIANA, YOU ARE BREAKING
UP A 

3925
02:27:25,881 --> 02:27:31,286
LITTLE BIT.

3926
02:27:31,286 --> 02:27:31,787
>> HOW ABOUT NOW?

3927
02:27:31,787 --> 02:27:33,155
>> I THINK THAT IS BETTER.

3928
02:27:33,155 --> 02:27:34,890
>> OKAY.

3929
02:27:34,890 --> 02:27:36,058
LET ME KNOW.

3930
02:27:36,058 --> 02:27:36,358
OKAY.

3931
02:27:36,358 --> 02:27:38,894
SO THE ABCD DATA SET HAS BEEN 

3932
02:27:38,894 --> 02:27:40,829
USED IN WELL OVER 1,000 

3933
02:27:40,829 --> 02:27:42,097
PEER-REVIEWED PUBLICATIONS.

3934
02:27:42,097 --> 02:27:43,966
ON THE LEFT THESE ARE PLOTTED BY

3935
02:27:43,966 --> 02:27:46,735
YEAR AND THE BLUE AND ORANGE 

3936
02:27:46,735 --> 02:27:48,137
INDICATE WHETHER THE PAPERS 

3937
02:27:48,137 --> 02:27:49,938
AUTHORS HAVE AFFILIATIONS WITH 

3938
02:27:49,938 --> 02:27:50,806
ABCD OR NOT.

3939
02:27:50,806 --> 02:27:52,074
I ESPECIALLY WANT TO HIGHLIGHT 

3940
02:27:52,074 --> 02:27:54,743
THE FACT THAT 60% OF THE 

3941
02:27:54,743 --> 02:27:56,044
PUBLICATIONS ARE BY RESEARCHERS 

3942
02:27:56,044 --> 02:27:59,047
OUTSIDE OF OUR CONSORTIUM, WHICH

3943
02:27:59,047 --> 02:28:02,918
SPEAKS TO THE SUCCESS OF OUR 

3944
02:28:02,918 --> 02:28:04,520
OPEN SCIENCE APPROACH.

3945
02:28:04,520 --> 02:28:08,023
THE STUDY'S FINDING ARE BEING 

3946
02:28:08,023 --> 02:28:10,392
DISSEMINATED TO BROADER 

3947
02:28:10,392 --> 02:28:11,860
AUDIENCES.

3948
02:28:11,860 --> 02:28:15,063
ALT METRIC KWAUBT FIS AMONG A 

3949
02:28:15,063 --> 02:28:16,799
LARGE RANGE OF OUTLETS.

3950
02:28:16,799 --> 02:28:19,168
THIS IS BROKEN DOWN BY SOURCE 

3951
02:28:19,168 --> 02:28:20,669
AND THE MAJORITY OF MENTIONS 

3952
02:28:20,669 --> 02:28:24,473
COME FROM TWITTER OR X, ABCD 

3953
02:28:24,473 --> 02:28:28,143
RESEARCH HAS RECEIVED MENTIONS 

3954
02:28:28,143 --> 02:28:28,710
ACROSS SEVERAL OTHER SOCIAL 

3955
02:28:28,710 --> 02:28:30,579
MEDIA PLATFORMS.

3956
02:28:30,579 --> 02:28:32,247
FOCUSING ON ONE OF THESE 

3957
02:28:32,247 --> 02:28:32,514
PLATFORMS.

3958
02:28:32,514 --> 02:28:34,483
HERE ARE A FEW EXAMPLES OF THE 

3959
02:28:34,483 --> 02:28:36,185
WIKIPEDIA ARTICLES THAT HAVE 

3960
02:28:36,185 --> 02:28:38,320
CITED ABCD PAPERS WHICH CAN HELP

3961
02:28:38,320 --> 02:28:40,222
US APPRECIATE THE BREADTH OF 

3962
02:28:40,222 --> 02:28:45,027
PUBLIC KNOWLEDGE THE STUDY IS 

3963
02:28:45,027 --> 02:28:45,694
CONTRIBUTING TO.

3964
02:28:45,694 --> 02:28:47,563
WE'RE ALSO STARTING TO SEE THE 

3965
02:28:47,563 --> 02:28:49,465
IMPACT OF ABCD SCIENCE ON 

3966
02:28:49,465 --> 02:28:51,400
CLINICAL AND OTHER GUIDANCE 

3967
02:28:51,400 --> 02:28:51,733
PUBLICATIONS.

3968
02:28:51,733 --> 02:28:54,169
FOR THIS I'M DRAWING ON DATA 

3969
02:28:54,169 --> 02:28:56,338
PROVIDED BY THE BRITISH MEDICAL 

3970
02:28:56,338 --> 02:28:59,408
JOURNAL IMPACT ANALYTIC SERVICE.

3971
02:28:59,408 --> 02:29:03,278
LAST MONTH 87 PAPERS USING ABCD 

3972
02:29:03,278 --> 02:29:05,948
DATA HAVE BEEN CITED IN 108 

3973
02:29:05,948 --> 02:29:07,049
CLINICAL AND OTHER DOCUMENTS.

3974
02:29:07,049 --> 02:29:10,752
THIS TABLE SHOULD APPEAR PT 

3975
02:29:10,752 --> 02:29:11,587
THERE WE GO.

3976
02:29:11,587 --> 02:29:14,323
THIS TABLE SHOWS THE BREAKDOWN 

3977
02:29:14,323 --> 02:29:15,691
OF DOCUMENTS INTO DIFFERENT 

3978
02:29:15,691 --> 02:29:15,991
CATEGORIES.

3979
02:29:15,991 --> 02:29:19,228
THE COLUMN HEADERS ON THE TOP 

3980
02:29:19,228 --> 02:29:21,830
SHOW FOUR MAIN SOURCES.

3981
02:29:21,830 --> 02:29:24,366
GOVERNMENT, IGO, 

3982
02:29:24,366 --> 02:29:25,067
INTERGOVERNMENTAL ORGANIZATION, 

3983
02:29:25,067 --> 02:29:28,871
THINK TANK AND PMC, GUIDELINES 

3984
02:29:28,871 --> 02:29:30,772
IN PUBMED CENTRAL.

3985
02:29:30,772 --> 02:29:33,542
EACH ROW IS A DIFFERENT TYPE OF 

3986
02:29:33,542 --> 02:29:33,942
DOCUMENT.

3987
02:29:33,942 --> 02:29:36,078
ON THE MAP ON THE RIGHT THESE 

3988
02:29:36,078 --> 02:29:38,547
DOCUMENTS COME FROM OVER 20 

3989
02:29:38,547 --> 02:29:42,217
COUNTRIES AS WELL AS SIX IGOs, 

3990
02:29:42,217 --> 02:29:45,120
W.H.O., UNITED NATIONS AND 

3991
02:29:45,120 --> 02:29:45,687
UNICEF.

3992
02:29:45,687 --> 02:29:47,489
I WILL SHOW EXAMPLES OF THE 

3993
02:29:47,489 --> 02:29:49,224
VARIOUS CATEGORIES OF DOCUMENTS.

3994
02:29:49,224 --> 02:29:51,493
THE DOCUMENTS CITING THE HIGHEST

3995
02:29:51,493 --> 02:29:54,196
NUMBER OF ABCD PAPERS IS THIS 

3996
02:29:54,196 --> 02:29:58,600
SYSTEMATIC REVIEW AND META 

3997
02:29:58,600 --> 02:30:03,071
ANALYSIS ON ADHD WITH 14 STUDIES

3998
02:30:03,071 --> 02:30:04,873
USING ABCD DATA.

3999
02:30:04,873 --> 02:30:08,577
IT IS TO SHOW EVIDENCE OF 

4000
02:30:08,577 --> 02:30:09,945
DIAGNOSIS, TREATMENT, AND 

4001
02:30:09,945 --> 02:30:13,148
MONITORING OF ADHD TO FORM AN 

4002
02:30:13,148 --> 02:30:14,917
UPDATE IN THE AMERICAN ACADEMY 

4003
02:30:14,917 --> 02:30:16,885
OF PEDIATRICS GUIDELINES.

4004
02:30:16,885 --> 02:30:19,321
THIS IS A GREAT EXAMPLE OF ABCD 

4005
02:30:19,321 --> 02:30:22,858
INFORMING CLINICAL PRACTICE.

4006
02:30:22,858 --> 02:30:26,128
LOOKING BEYOND THE U.S., A STUDY

4007
02:30:26,128 --> 02:30:29,598
USING ABCD DATA ON COGNITION, 

4008
02:30:29,598 --> 02:30:32,267
PHYSICAL ACTIVITY, SCREEN TIME 

4009
02:30:32,267 --> 02:30:35,904
WAS REPORTED TO THE USC K HOUSE 

4010
02:30:35,904 --> 02:30:36,605
OF KMONS.

4011
02:30:36,605 --> 02:30:39,474
ANOTHER PAPER EWING ABCD DATA 

4012
02:30:39,474 --> 02:30:41,376
STUDIED THE PREVALENCE AND 

4013
02:30:41,376 --> 02:30:42,644
FAMILY-RELATED FACTORS 

4014
02:30:42,644 --> 02:30:44,813
ASSOCIATED WITH SUICIDALITY AND 

4015
02:30:44,813 --> 02:30:46,048
SELF-INJURY WHICH HELPED INFORM 

4016
02:30:46,048 --> 02:30:50,652
A REPORT COMMISSIONED BY THE 

4017
02:30:50,652 --> 02:30:51,353
GOVERNMENT OF MALAYSIA.

4018
02:30:51,353 --> 02:30:54,723
ABCD RESEARCH HAS BEEN CITED BY 

4019
02:30:54,723 --> 02:30:57,192
PROMINENT THINK TANKSES, THE 

4020
02:30:57,192 --> 02:30:58,827
URBAN INSTITUTE IN THEIR REPORT 

4021
02:30:58,827 --> 02:31:00,495
RETURN ON INVESTING IN CHILDREN 

4022
02:31:00,495 --> 02:31:03,098
THAT USED STATE LEVEL 

4023
02:31:03,098 --> 02:31:05,167
MACROECONOMIC FACTORS MODERATE 

4024
02:31:05,167 --> 02:31:06,902
THE ASSOCIATION OF LOW INCOME 

4025
02:31:06,902 --> 02:31:07,703
BRAIN STRUCTURE AND MENTAL 

4026
02:31:07,703 --> 02:31:09,304
HEALTH IN U.S. CHILDREN TO 

4027
02:31:09,304 --> 02:31:10,906
SUPPORT THE ARGUMENT THAT 

4028
02:31:10,906 --> 02:31:12,140
GOVERNMENT ASSISTANCE IN THE 

4029
02:31:12,140 --> 02:31:14,576
FORM OF DIRECT CASH PAYMENTS TO 

4030
02:31:14,576 --> 02:31:16,712
FAMILIES HAS LONG-TERM BENEFITS 

4031
02:31:16,712 --> 02:31:18,880
FOR DEVELOPMENT.

4032
02:31:18,880 --> 02:31:21,116
AND A LEGAL MEMORANDUM FROM THE 

4033
02:31:21,116 --> 02:31:22,918
HERITAGE FOUNDATION CITED A 

4034
02:31:22,918 --> 02:31:25,153
STUDY ON PRENATAL CANNABIS 

4035
02:31:25,153 --> 02:31:26,521
EXPOSURE AND MENTAL HEALTH IN 

4036
02:31:26,521 --> 02:31:28,256
ABCD.

4037
02:31:28,256 --> 02:31:31,293
HIGHLIGHTING SUCH EXPOSURE SHOWS

4038
02:31:31,293 --> 02:31:33,795
RISK FOR VULNERABILITY TO BROAD 

4039
02:31:33,795 --> 02:31:35,797
SPECTRUM PSYCHOPATHOLOGY AS 

4040
02:31:35,797 --> 02:31:38,700
CHILDREN PROGRESS THROUGH EARLY 

4041
02:31:38,700 --> 02:31:39,301
ADOLESCENCE.

4042
02:31:39,301 --> 02:31:42,137
LOOKING AT INTERGOVERNMENTAL 

4043
02:31:42,137 --> 02:31:43,772
ORGANIZATIONS, THIS PAPER ON 

4044
02:31:43,772 --> 02:31:45,907
NEIGHBORHOOD DISADVANTAGE, 

4045
02:31:45,907 --> 02:31:47,643
NEUROKOIG IN ADDITION AND BRAIN 

4046
02:31:47,643 --> 02:31:52,047
STRUCTURE WAS IN A PAPER 

4047
02:31:52,047 --> 02:31:53,315
OPTIMIZING BRAIN HEALTH ALONG 

4048
02:31:53,315 --> 02:31:55,017
THE LIFE COURSE IN W.H.O.

4049
02:31:55,017 --> 02:31:57,586
AND A PAPER FOR CHILDHOOD 

4050
02:31:57,586 --> 02:31:59,488
SUICIDALITY WAS CITED IN THE 

4051
02:31:59,488 --> 02:32:02,858
HELPING ADOLESCENTS THRIVE 

4052
02:32:02,858 --> 02:32:04,493
TOOLKIT PUBLISHED BY THE W.H.O. 

4053
02:32:04,493 --> 02:32:08,196
AND UNICEF.

4054
02:32:08,196 --> 02:32:10,866
TO SUMMARIZE, EVEN BEFORE THE 

4055
02:32:10,866 --> 02:32:12,901
END OF THE CURRENT DATA 

4056
02:32:12,901 --> 02:32:14,236
COLLECTION ABCD HAS ALREADY HAD 

4057
02:32:14,236 --> 02:32:16,271
A GLOBAL IMPACT.

4058
02:32:16,271 --> 02:32:18,907
IT GENERATED MULTIDISCIPLINARY 

4059
02:32:18,907 --> 02:32:21,343
SCIENTIFIC FINDINGS LEADING TO 

4060
02:32:21,343 --> 02:32:22,711
NEARLY 1,300 PEER REVIEW PAPERS 

4061
02:32:22,711 --> 02:32:24,479
AN COUNTING.

4062
02:32:24,479 --> 02:32:25,881
THESE FOUNDINGS HAVE REACH NOT 

4063
02:32:25,881 --> 02:32:27,683
ONLY SCIENTISTS, CLINICIANS, 

4064
02:32:27,683 --> 02:32:29,818
POLICY MAKERS AND THE GENERAL 

4065
02:32:29,818 --> 02:32:30,052
PUBLIC.

4066
02:32:30,052 --> 02:32:31,053
THANK YOU AND I HOPE YOU HEARD 

4067
02:32:31,053 --> 02:32:33,655
MOST OF THAT.

4068
02:32:33,655 --> 02:32:36,191
>> YES, WE DID.

4069
02:32:36,191 --> 02:32:38,593
NOW I WOULD LIKE TO INTRODUCE 

4070
02:32:38,593 --> 02:32:40,162
COMMANDER TRACI MURRAY.

4071
02:32:40,162 --> 02:32:42,330
AND I SHOULD SAY IN THE LAST 

4072
02:32:42,330 --> 02:32:43,699
YEAR SINCE WE WERE HERE TRACI 

4073
02:32:43,699 --> 02:32:46,034
WAS PROMOTED TO COMMANDER, SO WE

4074
02:32:46,034 --> 02:32:48,603
ARE VERY PROUD OF THAT.

4075
02:32:48,603 --> 02:32:49,871
WHO IS GOING TO GIVE US A 

4076
02:32:49,871 --> 02:32:52,207
SUMMARY OF A REALLY EXCITING 

4077
02:32:52,207 --> 02:32:54,876
PAPER THAT CAME OUT EARLIER THIS

4078
02:32:54,876 --> 02:32:55,577
YEAR.

4079
02:32:55,577 --> 02:32:56,878
TRACI, ARE YOU THERE?

4080
02:32:56,878 --> 02:32:57,746
>> HI.

4081
02:32:57,746 --> 02:32:58,747
I'M HERE.

4082
02:32:58,747 --> 02:32:59,114
THANKS.

4083
02:32:59,114 --> 02:33:02,584
CAN YOU GO TO MY FIRST SLIDE, 

4084
02:33:02,584 --> 02:33:02,818
PLEASE.

4085
02:33:02,818 --> 02:33:03,285
>> DO YOU NOT SEE IT?

4086
02:33:03,285 --> 02:33:04,986
IS 

4087
02:33:04,986 --> 02:33:07,155
>> I'M STILL ON THE TITLE
SLIDE.

4088
02:33:07,155 --> 02:33:08,290
THERE WE GO.

4089
02:33:08,290 --> 02:33:10,726
TO START OFF I WOULD LIKE TO 

4090
02:33:10,726 --> 02:33:14,262
REMIND YOU OF SOME OF ABDD GOALS

4091
02:33:14,262 --> 02:33:16,298
FROM THIS 2018 ARTICLE.

4092
02:33:16,298 --> 02:33:17,299
THAT RESEARCHERS WOULD BE ABLE 

4093
02:33:17,299 --> 02:33:20,402
TO CLARIFY CAUSAL RELATIONSHIPS 

4094
02:33:20,402 --> 02:33:21,203
BETWEEN SUBSTANCE USE AND 

4095
02:33:21,203 --> 02:33:23,505
MULTIPLE ASSOCIATED OUTCOME AND 

4096
02:33:23,505 --> 02:33:26,908
IDENTIFY SOCIAL AND GENETIC 

4097
02:33:26,908 --> 02:33:28,710
VULNERABILITIES THEY MAY PRECEDE

4098
02:33:28,710 --> 02:33:30,912
SUBSTANCE USE AS WELL AS 

4099
02:33:30,912 --> 02:33:32,948
PROTECTIVE FACTORS THAT MIGHT 

4100
02:33:32,948 --> 02:33:34,716
MITIGATE RISK.

4101
02:33:34,716 --> 02:33:41,690
NEXT SLIDE.

4102
02:33:41,690 --> 02:33:43,859
>> THERE MUST BE A DELAY.

4103
02:33:43,859 --> 02:33:46,161
>> IS IT NOT COMING UP?

4104
02:33:46,161 --> 02:33:46,628
>> NO.

4105
02:33:46,628 --> 02:33:47,462
>> HERE WE GO.

4106
02:33:47,462 --> 02:33:49,898
JUST A DELAY.

4107
02:33:49,898 --> 02:33:51,800
WITH THAT IN MIND, I WOULD LIKE 

4108
02:33:51,800 --> 02:33:56,204
TO SHARE AN OVERVIEW OF OSBORNE 

4109
02:33:56,204 --> 02:34:01,076
ETAL PAPERS PSYCHOSIS SPECTRUM 

4110
02:34:01,076 --> 02:34:04,079
SYMPTOMS BEFORE AND AFTER 

4111
02:34:04,079 --> 02:34:06,014
CANNABIS USE INITIATION.

4112
02:34:06,014 --> 02:34:08,049
THIS TESTS THREE COMMON HIGHPOT 

4113
02:34:08,049 --> 02:34:10,919
CEASE RELATED TO CANNABIS KNICKS

4114
02:34:10,919 --> 02:34:13,855
IN EARLY ADOLESCENCE FOCUSING ON

4115
02:34:13,855 --> 02:34:20,061
BEFORE AND AFTER INITIATION.

4116
02:34:20,061 --> 02:34:22,430
PREVIOUS STUDIES FOCUSED ON MID 

4117
02:34:22,430 --> 02:34:26,835
TO LATE ADOLESCENTS, COMBINED 

4118
02:34:26,835 --> 02:34:28,703
ADOLESCENT AND ADULT SAMPLES OR 

4119
02:34:28,703 --> 02:34:31,006
USED RETROSPECTIVE REPORTS IN 

4120
02:34:31,006 --> 02:34:34,376
ADULT SAMPLES.

4121
02:34:34,376 --> 02:34:34,709
NEXT SLIDE.

4122
02:34:34,709 --> 02:34:36,011
GREAT TIMING.

4123
02:34:36,011 --> 02:34:38,613
THESE ARE ILLUSTRATIONS OF THE 

4124
02:34:38,613 --> 02:34:48,023
THREE HIGHP POPOT  -- HYPOTHESI 

4125
02:34:48,023 --> 02:34:48,223
TESTS.

4126
02:34:48,223 --> 02:34:51,993
THE X AXIS IS BEFORE THE 

4127
02:34:51,993 --> 02:34:53,461
INITIATION AND THE Y AX 

4128
02:34:53,461 --> 02:34:55,697
SITUATION IS THE NUMBER OF 

4129
02:34:55,697 --> 02:34:56,898
PSYCHOSIS INTERVENTIONS.

4130
02:34:56,898 --> 02:35:00,202
THE SOLID LINE IS ANYBODY WHO 

4131
02:35:00,202 --> 02:35:02,804
USED CANNABIS AND THE DOTTED 

4132
02:35:02,804 --> 02:35:04,372
ORANGE LINE IS THOSE WHO NEVER 

4133
02:35:04,372 --> 02:35:05,941
USED CANNABIS.

4134
02:35:05,941 --> 02:35:07,142
WITH SHARED VULNERABILITY THERE 

4135
02:35:07,142 --> 02:35:09,678
WOULD BE A DIFFERENCE IN 

4136
02:35:09,678 --> 02:35:11,346
PSYCHOSIS SYMPTOMS BETWEEN 

4137
02:35:11,346 --> 02:35:12,881
ADOLESCENTS WHO USED CANNABIS 

4138
02:35:12,881 --> 02:35:15,517
AND THOSE WHO DID NOT.

4139
02:35:15,517 --> 02:35:18,320
ADOLESCENTS WHO USED CANNABIS 

4140
02:35:18,320 --> 02:35:21,656
HAD FACTORS FOR DEVELOPING 

4141
02:35:21,656 --> 02:35:23,391
PSYCHOSIS SYMPTOMS.

4142
02:35:23,391 --> 02:35:26,561
'WED MAJOR LEAGUES INCREASING 

4143
02:35:26,561 --> 02:35:28,897
PSYCHOSIS SYMPTOMS WOULD PRECEDE

4144
02:35:28,897 --> 02:35:31,032
CANNABIS INITIATION.

4145
02:35:31,032 --> 02:35:33,168
PSYCHOSIS SYMPTOMS WOULD 

4146
02:35:33,168 --> 02:35:35,670
INCREASE AFTER CANNABIS 

4147
02:35:35,670 --> 02:35:35,971
INITIATION.

4148
02:35:35,971 --> 02:35:38,039
PREVIOUS EVIDENCE GENERALLY 

4149
02:35:38,039 --> 02:35:40,709
SUPPORTED CONTRIBUTING RISKS 

4150
02:35:40,709 --> 02:35:42,644
WITH MIXED EVIDENCE FOR 

4151
02:35:42,644 --> 02:35:43,011
SELF-MEDICATION.

4152
02:35:43,011 --> 02:35:44,546
RESEARCH IN TWIN SAMPLES 

4153
02:35:44,546 --> 02:35:46,681
SUGGESTED THAT PSYCHOSIS SAMPLES

4154
02:35:46,681 --> 02:35:49,251
IN ADOLESCENT CANNABIS USE 

4155
02:35:49,251 --> 02:35:50,886
CO-VARY, PARTIALLY DUE TO 

4156
02:35:50,886 --> 02:35:52,654
ENVIRONMENTAL FACTORS WITH MIXED

4157
02:35:52,654 --> 02:35:54,623
EVIDENCE FOR GENETIC 

4158
02:35:54,623 --> 02:36:00,395
CONTRIBUTIONS WHICH SUPPORTS 

4159
02:36:00,395 --> 02:36:01,930
SHARED VULNERABILITY.

4160
02:36:01,930 --> 02:36:04,532
SUBSTANCE USE AND DATES OF 

4161
02:36:04,532 --> 02:36:07,836
INITIATION WERE COLLECTED WITH 

4162
02:36:07,836 --> 02:36:09,704
ABCD INTERVIEW AND THE 

4163
02:36:09,704 --> 02:36:12,173
QUESTIONNAIRE WAS USED TO 

4164
02:36:12,173 --> 02:36:14,442
COLLECT PSYCHOSIS SYMPTOMS AND 

4165
02:36:14,442 --> 02:36:17,212
DISTRESS FROM THOSE SYMPTOMS.

4166
02:36:17,212 --> 02:36:22,784
THE STUDY ALSO STUDIED IF IT IS 

4167
02:36:22,784 --> 02:36:24,986
JUST CANNABIS OR OTHER SUB 

4168
02:36:24,986 --> 02:36:30,692
STAPSS AND THE OERKS COULD BE 

4169
02:36:30,692 --> 02:36:34,262
INTERNALIZING AND EXTERNALIZING 

4170
02:36:34,262 --> 02:36:34,529
SYMPTOMS.

4171
02:36:34,529 --> 02:36:36,665
THE FINDINGS SUPPORT SHARED 

4172
02:36:36,665 --> 02:36:38,900
VULNERABILITY IN 

4173
02:36:38,900 --> 02:36:40,802
SELF-MEDICATION.

4174
02:36:40,802 --> 02:36:43,905
SO ADOLESCENTS WHO USE CANNABIS 

4175
02:36:43,905 --> 02:36:48,610
AT ANY POINT REPORTED MORE 

4176
02:36:48,610 --> 02:36:51,146
DISTRESS FROM SYMPTOMS RELATIVE 

4177
02:36:51,146 --> 02:36:53,481
TO THOSE WHO NEVER USE DS 

4178
02:36:53,481 --> 02:36:53,748
CANNABIS.

4179
02:36:53,748 --> 02:36:57,085
THIS IS CONSISTENT WITH SHARED 

4180
02:36:57,085 --> 02:36:57,419
VULNERABILITY.

4181
02:36:57,419 --> 02:36:59,220
THE SYMPTOMS INCREASED IN THE 

4182
02:36:59,220 --> 02:37:04,859
TIME LEADING UP TO CANNABIS 

4183
02:37:04,859 --> 02:37:08,430
INITIATION THERE WAS 

4184
02:37:08,430 --> 02:37:10,532
INSUFFICIENT EVIDENCE FOR RISK.

4185
02:37:10,532 --> 02:37:12,767
PSYCHOSIS SYMPTOMS GENERALLY DID

4186
02:37:12,767 --> 02:37:14,903
NOT INCREASE AFTER CANNABIS 

4187
02:37:14,903 --> 02:37:24,479
INITIATION.

4188
02:37:24,479 --> 02:37:26,548
NOW WHILE THE CURRENT FINDINGS 

4189
02:37:26,548 --> 02:37:28,316
SUMMIT A SHARED VULNERABILITY 

4190
02:37:28,316 --> 02:37:30,919
AND SELF-MEDICATION THERE ARE 

4191
02:37:30,919 --> 02:37:31,853
IMPLICATIONS FOR FUTURE RESEARCH

4192
02:37:31,853 --> 02:37:33,388
TO SELF-MEDICATION AND 

4193
02:37:33,388 --> 02:37:34,089
CONTRIBUTING RISK.

4194
02:37:34,089 --> 02:37:35,991
FOR EXAMPLE, THE FINDINGS 

4195
02:37:35,991 --> 02:37:38,159
SUPPORTING SELF-MEDICATION DO 

4196
02:37:38,159 --> 02:37:41,162
NOT MEAN THAT CANNABIS USE IS 

4197
02:37:41,162 --> 02:37:43,365
EFFECTIVE FOR EA LEAVEUATING 

4198
02:37:43,365 --> 02:37:44,899
PSYCHOSIS SYMPTOMS.

4199
02:37:44,899 --> 02:37:46,267
RESEARCHERS NEED TO EXPLORE 

4200
02:37:46,267 --> 02:37:48,737
SHORT AND LONG-TERM EFFECTS OF 

4201
02:37:48,737 --> 02:37:50,939
CANNABIS USE ON SYMPTOMS.

4202
02:37:50,939 --> 02:37:52,340
THE LACK OF EVIDENCE MAY BE DUE 

4203
02:37:52,340 --> 02:37:56,845
TO THE STUDY'S FOCUS ON EARLY 

4204
02:37:56,845 --> 02:37:57,812
ADOLESCENCE WHEN FREQUENT HIGH 

4205
02:37:57,812 --> 02:38:00,648
VOLUME CANNABIS USE IS LESS 

4206
02:38:00,648 --> 02:38:01,116
COMMON.

4207
02:38:01,116 --> 02:38:03,418
PREVIOUS RESEARCH SHOWS A DOSE 

4208
02:38:03,418 --> 02:38:04,986
DEPENDENT ASSOCIATION BETWEEN 

4209
02:38:04,986 --> 02:38:08,690
CANNABIS USE AND PSYCHOSIS RISK 

4210
02:38:08,690 --> 02:38:10,792
WITH PSYCHOSIS RISK INCREASING 

4211
02:38:10,792 --> 02:38:11,760
WITH GREATER FREQUENCY AND 

4212
02:38:11,760 --> 02:38:13,194
QUANTITY OF CANNABIS USE.

4213
02:38:13,194 --> 02:38:16,598
IT IS NECESSARY TO STUDY LATER 

4214
02:38:16,598 --> 02:38:18,700
STAGES OF DEVELOPMENT WHEN 

4215
02:38:18,700 --> 02:38:20,602
CANNABIS USE GENERALLY 

4216
02:38:20,602 --> 02:38:21,469
INCREASES.

4217
02:38:21,469 --> 02:38:23,838
AN INCREASE IN PSYCHOSIS 

4218
02:38:23,838 --> 02:38:26,274
SYMPTOMS DOES NOT NECESSARILY 

4219
02:38:26,274 --> 02:38:29,744
MEAN AN INDIVIDUAL WILL HAVE A 

4220
02:38:29,744 --> 02:38:31,946
PSYCHOTIC DISORDER IN ADULTHOOD.

4221
02:38:31,946 --> 02:38:34,482
THIS STUDY ACHIEVES ABCD'S 

4222
02:38:34,482 --> 02:38:37,085
INITIAL GOALS BY PROVIDING A 

4223
02:38:37,085 --> 02:38:38,186
BETTER UNDERSTANDING OF 

4224
02:38:38,186 --> 02:38:39,387
ASSOCIATIONS BETWEEN CANNABIS 

4225
02:38:39,387 --> 02:38:43,191
USE AND PSYCHOSIS RISK DURING 

4226
02:38:43,191 --> 02:38:44,492
ADOLESCENTS AND POTENTIAL IMPACT

4227
02:38:44,492 --> 02:38:53,168
ON OTHER KOUT  -- KOUT COMES IN 

4228
02:38:53,168 --> 02:38:54,202
LATER LIFE.

4229
02:38:54,202 --> 02:38:56,838
IT IS IMPORTANT TO STUDY COHORT 

4230
02:38:56,838 --> 02:38:58,573
STUDIES AND HOW THOSE 

4231
02:38:58,573 --> 02:39:00,475
EXPERIENCES IMPACT DEVELOPMENT 

4232
02:39:00,475 --> 02:39:02,911
AND LONG-TERM OUTCOME.

4233
02:39:02,911 --> 02:39:06,214
NEXT SLIDE.

4234
02:39:06,214 --> 02:39:08,349
AS ABCD ENTERS THE YEAR NINE 

4235
02:39:08,349 --> 02:39:10,051
FOLLOW UP, WE ARE EXCITED TO 

4236
02:39:10,051 --> 02:39:12,854
SHARE PLANS FOR ABCD CONTINUING 

4237
02:39:12,854 --> 02:39:14,122
THE ARC OF DEVELOPMENT EXPERT 

4238
02:39:14,122 --> 02:39:14,889
PANEL MEETING.

4239
02:39:14,889 --> 02:39:17,425
WE ARE CONVENING SCIENTIFIC 

4240
02:39:17,425 --> 02:39:19,127
EXPERTS FROM VARIOUS FIELDS, 

4241
02:39:19,127 --> 02:39:22,497
YOUNG ADULTS WITH EXPERIENCE IN 

4242
02:39:22,497 --> 02:39:24,232
LONGITUDINAL RESEARCH AND ABCD 

4243
02:39:24,232 --> 02:39:25,166
EXPERTS WITH IN DEPTH KNOWLEDGE 

4244
02:39:25,166 --> 02:39:26,668
OF THE CURRENT PROTOCOL.

4245
02:39:26,668 --> 02:39:28,436
THE GOAL OFL THIS MEETING IS 

4246
02:39:28,436 --> 02:39:30,605
GATHER INPUT ON THE NEXT PHASE 

4247
02:39:30,605 --> 02:39:33,441
OF ABCD RELATE TO STUDY DESIGN, 

4248
02:39:33,441 --> 02:39:35,510
SOCIAL HEALTH AND ENVIRONMENT, 

4249
02:39:35,510 --> 02:39:42,717
SUBSTANCE USE AND MENTAL HEALTH.

4250
02:39:42,717 --> 02:39:44,819
THROUGHOUT MAY AND JUNE THESE 

4251
02:39:44,819 --> 02:39:47,589
GROUPS WILL PARTICIPATE IN TOPIC

4252
02:39:47,589 --> 02:39:50,091
SPECIFIC PREMEETINGS TO IDENTIFY

4253
02:39:50,091 --> 02:39:52,393
KEY CONSIDERATIONS IN THEIR 

4254
02:39:52,393 --> 02:39:53,695
RESPECTIVE AREAS THEN IN JULY WE

4255
02:39:53,695 --> 02:39:55,630
WILL HAVE AN IN-PERSON MEETING 

4256
02:39:55,630 --> 02:39:58,833
WITH ALL EXPERTS TO BUILD ON 

4257
02:39:58,833 --> 02:40:01,102
INPUT GATHERS FROM THOSE 

4258
02:40:01,102 --> 02:40:01,769
PREMEETINGS.

4259
02:40:01,769 --> 02:40:03,338
THIS MEETING WILL BE PUBLICLY 

4260
02:40:03,338 --> 02:40:04,839
AVAILABLE THROUGH VIDEOCAST AND 

4261
02:40:04,839 --> 02:40:06,241
THE PUBLIC VIEWERS WILL HAVE THE

4262
02:40:06,241 --> 02:40:08,309
OPPORTUNITY TO SUBMIT THEIR OWN 

4263
02:40:08,309 --> 02:40:16,151
COMMENTS TO US THROUGH VARIOUS 

4264
02:40:16,151 --> 02:40:16,451
MECHANISMS.

4265
02:40:16,451 --> 02:40:16,784
SO THANK YOU.

4266
02:40:16,784 --> 02:40:17,819
>> THANK YOU, TRACI.

4267
02:40:17,819 --> 02:40:19,687
I WOULD LIKE TO DO A GENERAL 

4268
02:40:19,687 --> 02:40:20,321
THANK YOU.

4269
02:40:20,321 --> 02:40:22,557
THIS STUDY INVOLVED SO MANY 

4270
02:40:22,557 --> 02:40:22,790
PEOPLE.

4271
02:40:22,790 --> 02:40:24,993
LIKE HBCD, THERE ARE 10 FEDERAL 

4272
02:40:24,993 --> 02:40:26,394
PARTNERS THAT ARE PART OF IT.

4273
02:40:26,394 --> 02:40:28,329
OF COURSE, THE 21 RESEARCH 

4274
02:40:28,329 --> 02:40:30,098
SITES, COORDINATING CENTER, THE 

4275
02:40:30,098 --> 02:40:32,133
DATA CENTER, THE INVESTIGATORS 

4276
02:40:32,133 --> 02:40:34,435
AND TRAINEES AND PARTICULARLY I 

4277
02:40:34,435 --> 02:40:36,671
HAVE TO DO A SHOUTOUT FOR THE 

4278
02:40:36,671 --> 02:40:38,473
RESEARCH ASSISTANTS AND STAFF, 

4279
02:40:38,473 --> 02:40:40,808
PARTICULARLY HOW THEY GOT 

4280
02:40:40,808 --> 02:40:42,544
THROUGH COVID WITHOUT -- WITH 

4281
02:40:42,544 --> 02:40:44,946
MINIMAL DATA LOSS AND KEEPING 

4282
02:40:44,946 --> 02:40:46,514
PEOPLE ENGAGED IS A TESTAMENT TO

4283
02:40:46,514 --> 02:40:47,649
THEIR EFFORTS.

4284
02:40:47,649 --> 02:40:49,083
AND THE NEARLY, OF COURSE, 

4285
02:40:49,083 --> 02:40:52,453
12,000 PARTICIPANTS AND THEIR 

4286
02:40:52,453 --> 02:40:54,022
FAMILIES WHO HAVE DEDICATED A 

4287
02:40:54,022 --> 02:40:55,456
LOT OF TIME FOR ABCD.

4288
02:40:55,456 --> 02:40:57,125
WITH THAT, I'M HAPPY TO TAKE 

4289
02:40:57,125 --> 02:40:58,493
QUESTIONS.

4290
02:40:58,493 --> 02:41:00,495
I WANTED TO START WITH AN ANSWER

4291
02:41:00,495 --> 02:41:01,996
TO KATE'S QUESTION FROM 

4292
02:41:01,996 --> 02:41:03,498
YESTERDAY ABOUT SEX DIFFERENCES.

4293
02:41:03,498 --> 02:41:05,500
WHETHER WE ARE SEEING SEX 

4294
02:41:05,500 --> 02:41:06,668
DIFFERENCES WITH RESPECT TO 

4295
02:41:06,668 --> 02:41:08,836
SUBSTANCE USE IN THE COHORT.

4296
02:41:08,836 --> 02:41:10,738
THERE WAS A PAPER THAT CAME OUT 

4297
02:41:10,738 --> 02:41:12,640
I THINK LAST YEAR FROM A 

4298
02:41:12,640 --> 02:41:14,475
PREVIOUS DATA RELEASE THAT 

4299
02:41:14,475 --> 02:41:15,777
SHOWED IN BASELINE THROUGH I 

4300
02:41:15,777 --> 02:41:19,681
THINK THE TWO-YEAR FOLLOW UP, 

4301
02:41:19,681 --> 02:41:21,716
THERE WAS MORE BOYS THAN GIRLS 

4302
02:41:21,716 --> 02:41:23,885
WERE ENDORSING SUBSTANCE USE.

4303
02:41:23,885 --> 02:41:26,187
BUT SINCE THEN AND AROUND THE 

4304
02:41:26,187 --> 02:41:29,190
THREE-YEAR FOLLOW UP IT EVENED 

4305
02:41:29,190 --> 02:41:29,357
OUT.

4306
02:41:29,357 --> 02:41:32,060
SINCE THEN IT APPEARS 

4307
02:41:32,060 --> 02:41:34,629
PRELIMINARY ANALYSIS MORE GIRLS 

4308
02:41:34,629 --> 02:41:36,164
ARE ENDORSING SUBSTANCE USE THAN

4309
02:41:36,164 --> 02:41:37,632
BOYS IN THE COHORT.

4310
02:41:37,632 --> 02:41:40,034
LET ME KNOW IF YOU HAVE 

4311
02:41:40,034 --> 02:41:41,469
FOLLOW-UP QUESTIONS TO THAT AND 

4312
02:41:41,469 --> 02:41:42,537
I'M OPEN TO ANYBODY ELSE'S 

4313
02:41:42,537 --> 02:41:46,441
QUESTION.

4314
02:41:46,441 --> 02:41:48,643
>> I ACTUALLY THANK YOU
VERY 

4315
02:41:48,643 --> 02:41:48,943
MUCH.

4316
02:41:48,943 --> 02:41:50,912
IT IS A GREAT PRESENTATION.

4317
02:41:50,912 --> 02:41:52,213
IT REFLECTS THE LEADERSHIP AND 

4318
02:41:52,213 --> 02:41:54,282
PASSION AND COMMITMENT OF THE 

4319
02:41:54,282 --> 02:41:54,716
WHOLE TEAM.

4320
02:41:54,716 --> 02:41:57,085
THE ONLY THING BEFORE WE GO INTO

4321
02:41:57,085 --> 02:41:58,653
QUESTIONS, I THINK THE AGENDA WE

4322
02:41:58,653 --> 02:42:03,491
ARE AT 1:10 FOR DATA SHARING 

4323
02:42:03,491 --> 02:42:05,260
PLATFORM FOR ABCD AND HBCD.

4324
02:42:05,260 --> 02:42:08,663
WE CAN DO THE FOLLOWING, WE CAN 

4325
02:42:08,663 --> 02:42:10,698
JUMP INTO THAT WITH DR. LISA 

4326
02:42:10,698 --> 02:42:12,100
HOFFMANN AND TAKE QUESTIONS 

4327
02:42:12,100 --> 02:42:12,967
LATER DURING THE DISCUSSION 

4328
02:42:12,967 --> 02:42:14,369
TIME, IF THAT'S OKAY.

4329
02:42:14,369 --> 02:42:17,772
>> THAT'S FINE WITH ME.

4330
02:42:17,772 --> 02:42:19,841
>> I'M JUST FOLLOWING THE
AGENDA

4331
02:42:19,841 --> 02:42:23,177
BECAUSE IT SAYS 1:10 AND IT IS 

4332
02:42:23,177 --> 02:42:23,378
1:12.

4333
02:42:23,378 --> 02:42:25,213
THAT WAS TERRIFIC.

4334
02:42:25,213 --> 02:42:26,914
WE SHOULD HAVE A PLAN FOR MORE 

4335
02:42:26,914 --> 02:42:27,282
TIME.

4336
02:42:27,282 --> 02:42:29,350
THAT WAS AN INCREDIBLE 

4337
02:42:29,350 --> 02:42:30,151
PRESENTATION.

4338
02:42:30,151 --> 02:42:32,620
THANKS A LOT, GAYA.

4339
02:42:32,620 --> 02:42:34,589
THEN THE NEXT PRESENTATION IS 

4340
02:42:34,589 --> 02:42:35,823
GOING TO BE GIVEN BY DR. 

4341
02:42:35,823 --> 02:42:37,191
ELIZABETH HOFFMANN, THE 

4342
02:42:37,191 --> 02:42:38,993
ASSOCIATE DIRECTOR OF THE ABCD 

4343
02:42:38,993 --> 02:42:40,695
STUDY AND SHE IS GOING TO GIVE 

4344
02:42:40,695 --> 02:42:43,598
US AN UPDATE ON THE DATA SHARING

4345
02:42:43,598 --> 02:42:47,835
PLATFORM FOR ABCD AND HBCD.

4346
02:42:47,835 --> 02:42:48,436
VERY, VERY IMPORTANT BECAUSE 

4347
02:42:48,436 --> 02:42:49,704
THIS HAS BEEN A MAJOR CHANGE IN 

4348
02:42:49,704 --> 02:42:51,906
THE WAY WE WERE COLLECTING AND 

4349
02:42:51,906 --> 02:42:53,574
MAKING THE DATA AVAILABLE AND IT

4350
02:42:53,574 --> 02:42:56,544
IS CRUCIAL FOR EVERYONE TO TAKE 

4351
02:42:56,544 --> 02:42:56,878
ADVANTAGE OF.

4352
02:42:56,878 --> 02:42:58,913
SO ELIZABETH, PLEASE JUMP IN.

4353
02:42:58,913 --> 02:43:01,316
>> THANK YOU, NORA AND
GOOD 

4354
02:43:01,316 --> 02:43:02,183
AFTERNOON, EVERYONE.

4355
02:43:02,183 --> 02:43:04,919
I AM REALLY EXCITED TO BE HERE 

4356
02:43:04,919 --> 02:43:06,521
BECAUSE I GET TO TELL YOU ABOUT 

4357
02:43:06,521 --> 02:43:08,723
THIS NEW DATA SHARING PLATFORM 

4358
02:43:08,723 --> 02:43:10,591
THAT IS VERY SOON TO LAUNCH.

4359
02:43:10,591 --> 02:43:11,492
NEXT MONTH.

4360
02:43:11,492 --> 02:43:13,795
IT HAS BEEN QUITE A LABOR OF 

4361
02:43:13,795 --> 02:43:15,263
LOVE FOR A LARGE NUMBER OF 

4362
02:43:15,263 --> 02:43:21,302
PEOPLE, NOT JUST FOLKS AT NIH, 

4363
02:43:21,302 --> 02:43:26,607
BUT ALSO LASSO INFORMATICS WHO 

4364
02:43:26,607 --> 02:43:28,476
HAS DEALT WITH A LOT OF CHANGES 

4365
02:43:28,476 --> 02:43:30,912
ALONG THE WAY AND THEY HAVE BEEN

4366
02:43:30,912 --> 02:43:32,380
VERY NIMBLE.

4367
02:43:32,380 --> 02:43:34,349
I'M HUGELY APPRECIATIVE OF THEM.

4368
02:43:34,349 --> 02:43:37,051
TO GIVE YOU A QUICK TEASER HERE,

4369
02:43:37,051 --> 02:43:38,186
THIS IS THE SPLASH PAGE.

4370
02:43:38,186 --> 02:43:40,855
IT IS NOT LIVE YET.

4371
02:43:40,855 --> 02:43:43,057
OF THE NIH BRAND DEVELOPMENT 

4372
02:43:43,057 --> 02:43:43,825
COHORT DATA HUB.

4373
02:43:43,825 --> 02:43:44,859
WILL BE IN JUNE.

4374
02:43:44,859 --> 02:43:48,296
THIS IS WHAT YOU WILL SEE COMING

4375
02:43:48,296 --> 02:43:48,463
IN.

4376
02:43:48,463 --> 02:43:49,664
IT IS ALREADY OUT OF DATE.

4377
02:43:49,664 --> 02:43:52,166
WE WILL HAVE OTHER FEATURES HERE

4378
02:43:52,166 --> 02:43:53,000
INCLUDING AN ANNOUNCEMENTS BLOCK

4379
02:43:53,000 --> 02:43:54,235
AT THE BOTTOM.

4380
02:43:54,235 --> 02:43:56,237
THIS IS WHERE USERS WILL COME 

4381
02:43:56,237 --> 02:43:59,474
WHEN THEY COME INTO THE NIH 

4382
02:43:59,474 --> 02:44:01,309
BRAND DEVELOPMENT'S COHORT'S 

4383
02:44:01,309 --> 02:44:02,243
DATA HUB.

4384
02:44:02,243 --> 02:44:05,446
YOU WILL SEE A WELCOME VIDEO 

4385
02:44:05,446 --> 02:44:08,116
FROM NORA ON THE LOWER RIGHT.

4386
02:44:08,116 --> 02:44:10,885
THIS RESOURCE IS REALLY DESIGNED

4387
02:44:10,885 --> 02:44:13,788
TO ACCELERATE SCIENTIFIC 

4388
02:44:13,788 --> 02:44:15,890
DISCOVERY BY PROVIDING 

4389
02:44:15,890 --> 02:44:18,025
CENTRALIZED ACCESS TO RICH 

4390
02:44:18,025 --> 02:44:20,094
LONGITUDINAL DATA, BRAIN, 

4391
02:44:20,094 --> 02:44:23,598
BEHAVIORAL AND GENOMIC DATA FROM

4392
02:44:23,598 --> 02:44:26,567
ABCD AND HBCD STUDIES.

4393
02:44:26,567 --> 02:44:27,502
BY BRINGING TOGETHER DATA FROM 

4394
02:44:27,502 --> 02:44:35,643
BOTH OF THESE STUDIES THAT THE 

4395
02:44:35,643 --> 02:44:37,678
NBDC IS GOOD RESEARCH THROUGH 

4396
02:44:37,678 --> 02:44:40,782
EARLY LIFE AND EARLY ADULTHOOD 

4397
02:44:40,782 --> 02:44:44,752
WHICH HELPS TRAJECTORIES ACROSS 

4398
02:44:44,752 --> 02:44:45,953
A BROAD AGE RANGE AND 

4399
02:44:45,953 --> 02:44:46,254
POPULATIONS.

4400
02:44:46,254 --> 02:44:49,490
IT PROMISES TO BE AN INCREDIBLY 

4401
02:44:49,490 --> 02:44:50,892
RICH RESOURCE WHICH WE ARE 

4402
02:44:50,892 --> 02:44:51,359
EXCITED ABOUT.

4403
02:44:51,359 --> 02:44:52,059
SO WHY NOW?

4404
02:44:52,059 --> 02:44:54,195
THERE ARE A LOT OF REASONS WHY 

4405
02:44:54,195 --> 02:44:55,463
NOW, BUT I PROBABLY DON'T NEED 

4406
02:44:55,463 --> 02:44:57,432
TO TELL THIS GROUP, BUT I HAVE 

4407
02:44:57,432 --> 02:44:58,900
HIGHLIGHTED A FEW HERE.

4408
02:44:58,900 --> 02:45:01,536
FIRSTLY, I WOULD SAY POPULATION 

4409
02:45:01,536 --> 02:45:03,070
NEUROSCIENCE, WE ARE AT A 

4410
02:45:03,070 --> 02:45:04,205
PIVOTAL MOMENT NOW WHERE THERE 

4411
02:45:04,205 --> 02:45:09,777
IS AN INCREASING NEED FOR 

4412
02:45:09,777 --> 02:45:10,511
RESPONDING TO HOW RESEARCHERS 

4413
02:45:10,511 --> 02:45:12,313
ARE USING DATA.

4414
02:45:12,313 --> 02:45:14,415
THERE NEEDS TO BE INCREASED 

4415
02:45:14,415 --> 02:45:16,083
SCALEABILITY, I THINK, AND BROAD

4416
02:45:16,083 --> 02:45:18,152
ACCESSIBILITY TO A WIDE VARIETY 

4417
02:45:18,152 --> 02:45:20,521
OF USERS ARE VARYING TECHNICAL 

4418
02:45:20,521 --> 02:45:20,788
EXPERTISE.

4419
02:45:20,788 --> 02:45:24,325
WE ARE DEALING WITH INCREASINGLY

4420
02:45:24,325 --> 02:45:26,594
COMPLEX AND DIVERSE 

4421
02:45:26,594 --> 02:45:29,897
HETEROGENEOUS DATA TYPES, GE

4422
02:45:29,897 --> 02:45:33,034
GENOMICS DATA AND THROUGH FITBIT

4423
02:45:33,034 --> 02:45:34,535
DATA COLLECTION AND A 

4424
02:45:34,535 --> 02:45:36,170
TREMENDOUSLY LARGE VOLUME OF 

4425
02:45:36,170 --> 02:45:43,578
DATA ON THE ORDER OF PETABYTES 

4426
02:45:43,578 --> 02:45:48,182
FOR ABCD AND HBCD.

4427
02:45:48,182 --> 02:45:50,685
THE NBCD SYSTEM IS GOING TO 

4428
02:45:50,685 --> 02:45:52,153
HANDLE ALL OF THIS SEAMLESSLY, 

4429
02:45:52,153 --> 02:45:54,288
WE ARE HOPING, WE ARE EXPECTING.

4430
02:45:54,288 --> 02:45:56,123
A FEW THINGS I WOULD LIKE TO 

4431
02:45:56,123 --> 02:45:58,526
HIGHLIGHT COMPONENTS OF THIS 

4432
02:45:58,526 --> 02:46:00,261
SYSTEM TO FACILITATE ACCESS TO A

4433
02:46:00,261 --> 02:46:02,730
WIDE VARIETY OF USERS AND DATA 

4434
02:46:02,730 --> 02:46:05,600
USE AND ANALYSIS IN PLACE IN 

4435
02:46:05,600 --> 02:46:07,268
CONTRAST TO OLDER DATA 

4436
02:46:07,268 --> 02:46:14,675
REPOSITORIES HIS TOR -- 

4437
02:46:14,675 --> 02:46:15,009
HISTORICALLY.

4438
02:46:15,009 --> 02:46:17,512
THERE WILL BE TRAINING THAT 

4439
02:46:17,512 --> 02:46:19,647
ACCOMPANIES THE DATA USE 

4440
02:46:19,647 --> 02:46:20,348
CERTIFICATION.

4441
02:46:20,348 --> 02:46:22,016
USERS NEED TO COMPLETE 

4442
02:46:22,016 --> 02:46:23,618
RESPONSIBLE USE TRAINING, 

4443
02:46:23,618 --> 02:46:26,654
COMPLETE A QUIZ AND GET A 90% 

4444
02:46:26,654 --> 02:46:28,356
PASS RATE TO GET ACCESS TO THE 

4445
02:46:28,356 --> 02:46:29,090
DATA.

4446
02:46:29,090 --> 02:46:30,625
THAT GETS RENEWED EVERY YEAR.

4447
02:46:30,625 --> 02:46:32,093
THEY HAVE TO TAKE A QUIZ EVERY 

4448
02:46:32,093 --> 02:46:32,293
YEAR.

4449
02:46:32,293 --> 02:46:34,896
THIS IS REALLY TO HELP SORT OF 

4450
02:46:34,896 --> 02:46:37,231
LEVEL THE PLAYING FIELD SO WE 

4451
02:46:37,231 --> 02:46:39,100
DON'T EXPECT EVERYBODY COMING IN

4452
02:46:39,100 --> 02:46:40,635
TO HAVE EQUAL LEVELS OF 

4453
02:46:40,635 --> 02:46:42,436
KNOWLEDGE TO USE DATA, MAINTAIN 

4454
02:46:42,436 --> 02:46:44,605
SECURITY OF DATA AND SO ON.

4455
02:46:44,605 --> 02:46:47,074
THIS PROVIDES OPPORTUNITIES FOR 

4456
02:46:47,074 --> 02:46:48,643
THAT LEARNING.

4457
02:46:48,643 --> 02:46:52,179
THEN THERE WILL BE MULTIPLE WAYS

4458
02:46:52,179 --> 02:46:57,685
TO QUERY THE DATA AND INTEGRATED

4459
02:46:57,685 --> 02:46:58,586
DATA ANALYTIC TOOLS.

4460
02:46:58,586 --> 02:47:00,555
THIS IS IMPORTANT AND THE THING 

4461
02:47:00,555 --> 02:47:05,059
WE ARE MOST EXCITED ABOUT AND 

4462
02:47:05,059 --> 02:47:07,194
MOST INNOVATIVE.

4463
02:47:07,194 --> 02:47:10,064
USERS CAN DO DATA ANALYSIS IN 

4464
02:47:10,064 --> 02:47:12,600
PLACE REDUCING THE NEED TO 

4465
02:47:12,600 --> 02:47:13,868
DOWNLOAD DATA.

4466
02:47:13,868 --> 02:47:16,037
THIS WON'T BE AVAILABLE 

4467
02:47:16,037 --> 02:47:17,872
IMMEDIATELY, BUT IN THE NEXT 

4468
02:47:17,872 --> 02:47:21,976
SEVERAL MONTHS ON TABULATED DATA

4469
02:47:21,976 --> 02:47:23,244
AND FILE BASED DATA.

4470
02:47:23,244 --> 02:47:24,946
THERE WILL BE A SECURE 

4471
02:47:24,946 --> 02:47:25,613
COLLABORATION SPACE.

4472
02:47:25,613 --> 02:47:27,381
SO USERS WILL BE ABLE TO COME 

4473
02:47:27,381 --> 02:47:28,950
INTO THIS DESIGNATED SPACE IN 

4474
02:47:28,950 --> 02:47:31,819
THE SYSTEM AND COLLABORATE WITH 

4475
02:47:31,819 --> 02:47:32,720
OTHER USERS.

4476
02:47:32,720 --> 02:47:35,289
DOING SIMILAR ANALYSES AND 

4477
02:47:35,289 --> 02:47:37,658
COMPLETE, CONDUCT PROJECTS 

4478
02:47:37,658 --> 02:47:38,359
TOGETHER COLLABORATIVELY IN THIS

4479
02:47:38,359 --> 02:47:40,795
SPACE AGAIN WITHOUT THE NEED TO 

4480
02:47:40,795 --> 02:47:42,363
DOWNLOAD DATA BUT STILL 

4481
02:47:42,363 --> 02:47:44,365
MAINTAINING THAT COLLABORATION 

4482
02:47:44,365 --> 02:47:45,299
ACROSS INSTITUTIONS.

4483
02:47:45,299 --> 02:47:48,469
AND THEN FINALLY, THERE'S GOING 

4484
02:47:48,469 --> 02:47:51,305
TO BE A VERY DYNAMIC AND GROWING

4485
02:47:51,305 --> 02:47:52,607
KNOWLEDGE BASE THAT WILL 

4486
02:47:52,607 --> 02:47:53,774
ACCOMPANY THIS SYSTEM SO USERS 

4487
02:47:53,774 --> 02:47:56,644
WILL BE ABLE TO COME IN AND ASK 

4488
02:47:56,644 --> 02:47:58,112
WHATEVER GRANULAR LEVEL 

4489
02:47:58,112 --> 02:47:59,447
QUESTIONS THEY HAVE ABOUT 

4490
02:47:59,447 --> 02:48:02,450
PARTICULAR DATA TYPES OVER TIME 

4491
02:48:02,450 --> 02:48:03,150
AND THINGS INVOLVE WITH 

4492
02:48:03,150 --> 02:48:04,518
DIFFERENT DATA RELEASES.

4493
02:48:04,518 --> 02:48:06,253
THIS GETS COMPLEX WITH THE 

4494
02:48:06,253 --> 02:48:07,455
AMOUNT OF INFORMATION NEEDED IS 

4495
02:48:07,455 --> 02:48:08,356
GROWING CONSTANTLY.

4496
02:48:08,356 --> 02:48:10,558
THERE IS ALSO, IF THAT IS NOT 

4497
02:48:10,558 --> 02:48:13,594
HELPFUL ENOUGH, THERE IS A 

4498
02:48:13,594 --> 02:48:15,262
HEALTH TICKETING SYSTEM TO COME 

4499
02:48:15,262 --> 02:48:17,431
IN AND PUT A TICKET IN THE THEY 

4500
02:48:17,431 --> 02:48:18,899
ARE NOT GETTING ANYWHERE WITH 

4501
02:48:18,899 --> 02:48:20,868
THE KNOWLEDGE BASE AND TRIAGED 

4502
02:48:20,868 --> 02:48:22,303
TO SUBJECT MATTER EXPERTS.

4503
02:48:22,303 --> 02:48:25,006
WE HOPE THIS WILL BE A RESOURCE 

4504
02:48:25,006 --> 02:48:27,675
THAT IS POWERFUL AND PROVIDES 

4505
02:48:27,675 --> 02:48:29,577
OPPORTUNITIES FOR FOLKS TO GET 

4506
02:48:29,577 --> 02:48:30,611
MORE INFORMATION THEY OTHERWISE 

4507
02:48:30,611 --> 02:48:35,116
WOULDN'T BE ABLE TO HAVE.

4508
02:48:35,116 --> 02:48:36,817
AND I REALLY LIKE THIS SLIDE 

4509
02:48:36,817 --> 02:48:38,586
BECAUSE IT HIGHLIGHTS WHAT I 

4510
02:48:38,586 --> 02:48:39,654
THINK IS THE SECOND MOST 

4511
02:48:39,654 --> 02:48:41,555
WONDERFUL THING ABOUT THIS 

4512
02:48:41,555 --> 02:48:41,856
SYSTEM.

4513
02:48:41,856 --> 02:48:43,924
THE IN PLACE DATA ANALYTICS IS 

4514
02:48:43,924 --> 02:48:47,261
THE FIRST AND THE SECOND IS THE 

4515
02:48:47,261 --> 02:48:50,431
INTENTIONAL REDUNDANCIES BUILT 

4516
02:48:50,431 --> 02:48:51,265
IN THIS SYSTEM.

4517
02:48:51,265 --> 02:48:54,268
WE HAVE VARYING LEVELS OF 

4518
02:48:54,268 --> 02:48:55,202
TECHNICAL EXPERTISE AND 

4519
02:48:55,202 --> 02:48:56,871
EXPECTATIONS THAT USERS HAVE HOW

4520
02:48:56,871 --> 02:49:00,007
THEY WANT TO CONDUCT ANALYSES.

4521
02:49:00,007 --> 02:49:05,379
THERE ARE MULTIPLE WAYS OF 

4522
02:49:05,379 --> 02:49:06,280
QUERYING DATA.

4523
02:49:06,280 --> 02:49:08,516
THE LEFT IS DATA EXPLORATION AND

4524
02:49:08,516 --> 02:49:09,617
ANALYSIS PORTAL.%

4525
02:49:09,617 --> 02:49:11,318
SOME OF YOU MAY BE FAMILIAR WITH

4526
02:49:11,318 --> 02:49:11,552
THAT.

4527
02:49:11,552 --> 02:49:13,621
IT IS NOW COMING BACK ONLINE, 

4528
02:49:13,621 --> 02:49:17,091
NEW AND IMPROVED WITH GREATER 

4529
02:49:17,091 --> 02:49:17,792
FUNCTIONALITIES.

4530
02:49:17,792 --> 02:49:19,827
THE FIRST HERE IN DATA 

4531
02:49:19,827 --> 02:49:21,762
DICTIONARY VIEWER, THIS 

4532
02:49:21,762 --> 02:49:23,698
COMPONENT IS AVAILABLE TO THE 

4533
02:49:23,698 --> 02:49:23,931
PUBLIC.

4534
02:49:23,931 --> 02:49:26,534
IT DOESN'T REQUIRE A USER 

4535
02:49:26,534 --> 02:49:27,034
AUTHENTICATING IN.

4536
02:49:27,034 --> 02:49:29,637
IT IS OPPORTUNITIES TO VIEW THE 

4537
02:49:29,637 --> 02:49:30,905
DICTIONARIES AND HIGH LEVEL 

4538
02:49:30,905 --> 02:49:34,709
SUMMARY STATISTICS OF THE COH

4539
02:49:34,709 --> 02:49:36,010
COHORT, VERY HIGH LEVEL.

4540
02:49:36,010 --> 02:49:38,145
AND TABULATED DATA STORAGE, 

4541
02:49:38,145 --> 02:49:40,648
OPPORTUNITIES FOR CREATED AND 

4542
02:49:40,648 --> 02:49:43,651
DOWNLOADING DATA SETS.

4543
02:49:43,651 --> 02:49:46,220
STATISTICS, VARYING LEVELS OF 

4544
02:49:46,220 --> 02:49:47,288
STATISTICS.

4545
02:49:47,288 --> 02:49:49,657
DEWEY BASED AND CODING 

4546
02:49:49,657 --> 02:49:50,791
ENVIRONMENTS THAT IS COMING 

4547
02:49:50,791 --> 02:49:51,525
LATER IN 2025.

4548
02:49:51,525 --> 02:49:54,228
THE LASSO SYSTEM, THIS IS HERE 

4549
02:49:54,228 --> 02:49:56,664
AT THE TOP, I MENTIONED LASSO IS

4550
02:49:56,664 --> 02:49:59,233
A COMPANY FACILITATES THIS.

4551
02:49:59,233 --> 02:50:02,636
THAT IS WHERE USERS WILL LOG IN.

4552
02:50:02,636 --> 02:50:06,073
THAT IS THE CENTRALIZED 

4553
02:50:06,073 --> 02:50:07,875
AUTHENTICATION SPACE WHERE 

4554
02:50:07,875 --> 02:50:09,410
PEOPLE COME IN AND COMPLETE 

4555
02:50:09,410 --> 02:50:11,312
THEIR CERTIFICATION AND 

4556
02:50:11,312 --> 02:50:12,480
TRAINING.

4557
02:50:12,480 --> 02:50:17,118
THERE IS QUERYING AND DATA BASE 

4558
02:50:17,118 --> 02:50:18,252
AND STORAGE BUILT IN THERE.

4559
02:50:18,252 --> 02:50:20,621
ON THE LOWER RIGHT, PRIMARILY 

4560
02:50:20,621 --> 02:50:23,591
FOCUSED ON FILE-BASED DATA 

4561
02:50:23,591 --> 02:50:25,426
STORAGE SO INCREASING 

4562
02:50:25,426 --> 02:50:26,694
COMPUTATION AND STORAGE NEEDS 

4563
02:50:26,694 --> 02:50:27,828
FOR THOSE DATA.

4564
02:50:27,828 --> 02:50:29,396
THERE IS ANOTHER COMPONENT HERE 

4565
02:50:29,396 --> 02:50:30,264
AT THE UNIVERSITY OF MINNESOTA 

4566
02:50:30,264 --> 02:50:31,365
THAT IS HELPING WITH THAT.

4567
02:50:31,365 --> 02:50:33,367
THERE IS FILE-BASED STORAGE 

4568
02:50:33,367 --> 02:50:35,603
AVAILABLE IN THE SPRING AND THEN

4569
02:50:35,603 --> 02:50:37,304
COMING LATER IN 2025, THERE WILL

4570
02:50:37,304 --> 02:50:40,441
BE OPPORTUNITIES TO DO THESE 

4571
02:50:40,441 --> 02:50:41,942
COLLABORATIONS, DATA SHARES.

4572
02:50:41,942 --> 02:50:44,578
YOU CAN SEE IN THE ON-DEMAND BOX

4573
02:50:44,578 --> 02:50:45,513
IN THE LOWER RIGHT.

4574
02:50:45,513 --> 02:50:50,584
THE DATAS ATTACHED HERE ARE A 

4575
02:50:50,584 --> 02:50:53,754
LITTLE BIT HOPEFUL, BUT I THINK 

4576
02:50:53,754 --> 02:50:55,456
AS WE GET CLOSER I'M MORE 

4577
02:50:55,456 --> 02:50:56,924
CONFIDENT WE WILL MEET THEM.

4578
02:50:56,924 --> 02:50:58,959
LOOK OUT FOR THESE AS THE 

4579
02:50:58,959 --> 02:51:00,528
PLATFORM LAUNCHES AND WE WILL 

4580
02:51:00,528 --> 02:51:01,829
MESSAGE ABOUT THE ADDITIONAL 

4581
02:51:01,829 --> 02:51:05,199
FUNCTIONALITIES IN TIME.

4582
02:51:05,199 --> 02:51:06,901
SO THE DATA ACCESS PROCESS.

4583
02:51:06,901 --> 02:51:09,336
I WANTED TO SPEND A COUPLE OF 

4584
02:51:09,336 --> 02:51:10,871
MINUTES ON THIS BECAUSE THOSE 

4585
02:51:10,871 --> 02:51:13,674
WHO ACCESSED DATA FROM NDA IN 

4586
02:51:13,674 --> 02:51:16,777
THE PAST WILL BE USED TO A 

4587
02:51:16,777 --> 02:51:21,015
SOMEWHAT DIFFERENT WAY OF 

4588
02:51:21,015 --> 02:51:23,150
APPLYING FOR A DATA USE 

4589
02:51:23,150 --> 02:51:23,484
CERTIFICATION.

4590
02:51:23,484 --> 02:51:25,419
FIRSTLY THERE ARE A COUPLE OF 

4591
02:51:25,419 --> 02:51:26,987
DIFFERENT WORK FLOWS FOR 

4592
02:51:26,987 --> 02:51:30,858
APPLYING FOR DATA USE CERT

4593
02:51:30,858 --> 02:51:31,659
CERTIFICA

4594
02:51:31,659 --> 02:51:31,992
CERTIFICATION.

4595
02:51:31,992 --> 02:51:33,327
THERE IS INDIVIDUAL AND BOOTH 

4596
02:51:33,327 --> 02:51:33,594
LEVEL.

4597
02:51:33,594 --> 02:51:37,131
INDIVIDUAL IS SOMEBODY COMES IN,

4598
02:51:37,131 --> 02:51:41,202
SINGLE PERSON INVESTIGATOR 

4599
02:51:41,202 --> 02:51:42,002
CONDUCTING ANALYSES.

4600
02:51:42,002 --> 02:51:44,572
MAYBE THEY HAVE A BIG LAB AND 

4601
02:51:44,572 --> 02:51:46,740
THEY COME IN TOGETHER FROM THE 

4602
02:51:46,740 --> 02:51:48,742
SAME INSTITUTION ON A GROUP LEFT

4603
02:51:48,742 --> 02:51:49,243
DUC.

4604
02:51:49,243 --> 02:51:51,712
THAT IS A MORE COMMON WORK FLOW 

4605
02:51:51,712 --> 02:51:52,947
THAT FOLKS WILL UTILIZE.

4606
02:51:52,947 --> 02:51:55,716
AS I MENTIONED BEFORE, EVERYONE 

4607
02:51:55,716 --> 02:51:57,551
INCLUDING THE TRAINEES WILL NEED

4608
02:51:57,551 --> 02:51:59,920
TO COMPLETE TRAINING ON 

4609
02:51:59,920 --> 02:52:01,922
RESPONSIBILITY USE OF THE DATA 

4610
02:52:01,922 --> 02:52:02,957
AND KNOWLEDGE QUIZ TO GAIN 

4611
02:52:02,957 --> 02:52:03,891
ACCESS TO THE DATA.

4612
02:52:03,891 --> 02:52:06,327
AND THE DATA USE AGREEMENT IS 

4613
02:52:06,327 --> 02:52:08,429
VALID FOR A YEAR AND USERS CAN 

4614
02:52:08,429 --> 02:52:12,666
RENEW AT THAT TIME.

4615
02:52:12,666 --> 02:52:14,401
WE ALSO ARE IMPLEMENTING 

4616
02:52:14,401 --> 02:52:16,503
DEVELOPMENT INTO THE SYSTEM THAT

4617
02:52:16,503 --> 02:52:18,372
REFLECTS NEW NIH SECURITY 

4618
02:52:18,372 --> 02:52:19,440
COMPLIANCE REQUIREMENTS.

4619
02:52:19,440 --> 02:52:21,675
THIS IS NOT A PLATFORM 

4620
02:52:21,675 --> 02:52:23,043
REQUIREMENT OR A NIDA 

4621
02:52:23,043 --> 02:52:25,913
REQUIREMENT, IT IS NIH-WIDE, 

4622
02:52:25,913 --> 02:52:26,780
SECURITY COMPLIANCE.

4623
02:52:26,780 --> 02:52:29,149
APPROVED USERS OF THE DATA HAVE 

4624
02:52:29,149 --> 02:52:32,653
TO COMPLY WITH THE SECURITY BEST

4625
02:52:32,653 --> 02:52:32,920
PRACTICES.

4626
02:52:32,920 --> 02:52:34,889
IF THEY ARE OPTING TO DOWNLOAD 

4627
02:52:34,889 --> 02:52:35,089
DATA.

4628
02:52:35,089 --> 02:52:40,527
THEY HAVE TO ATTEST TO HAVING 

4629
02:52:40,527 --> 02:52:42,863
COME CLINES SYSTEM OR A PLAN IN 

4630
02:52:42,863 --> 02:52:45,566
PLACE TO BE CONSIDERED 

4631
02:52:45,566 --> 02:52:45,833
COMPLIANT.

4632
02:52:45,833 --> 02:52:47,301
THE REASON ALL RECIPIENTS NEED 

4633
02:52:47,301 --> 02:52:49,937
TO HAVE A PLAN IN PLACE IS THAT 

4634
02:52:49,937 --> 02:52:53,073
IT IS NEEDED FOR DATA DOWNLOAD.

4635
02:52:53,073 --> 02:52:56,443
THAT IS ONLY FUNCTIONALITY WE 

4636
02:52:56,443 --> 02:52:58,979
HAVE WHEN THE SYSTEM LAUNCHES.

4637
02:52:58,979 --> 02:53:00,748
BUT INSTITUTE FUNCTIONALITIES 

4638
02:53:00,748 --> 02:53:02,616
WILL BE AVAILABLE VERY SOON.

4639
02:53:02,616 --> 02:53:04,418
RIGHT NOW WHEN A USER COMES IN 

4640
02:53:04,418 --> 02:53:05,819
TO ACCESS THE DATA, 

4641
02:53:05,819 --> 02:53:06,887
UNFORTUNATELY, IF THEY DON'T 

4642
02:53:06,887 --> 02:53:10,157
HAVE A PLAN IN PLACE FOR NIST 

4643
02:53:10,157 --> 02:53:11,358
COMPLIANCE, THEY CAN'T GET 

4644
02:53:11,358 --> 02:53:12,893
APPROVAL TO ACCESS THE DATA.

4645
02:53:12,893 --> 02:53:14,895
IF THEY HAVE A PLAN IN PLACE 

4646
02:53:14,895 --> 02:53:17,031
EVEN IF THEY DON'T HAVE THE 

4647
02:53:17,031 --> 02:53:18,565
COMPLIANCE IN PLACE ITSELF, THAT

4648
02:53:18,565 --> 02:53:20,134
IS ENOUGH TO HAVE ACCESS TO THE 

4649
02:53:20,134 --> 02:53:20,834
DATA.

4650
02:53:20,834 --> 02:53:24,838
WHEN WE HAVE THE INSTITUTE 

4651
02:53:24,838 --> 02:53:25,706
FUNCTIONALITIES BUILT INTO THE 

4652
02:53:25,706 --> 02:53:29,476
SYSTEM THERE IS AN ADDITIONAL 

4653
02:53:29,476 --> 02:53:31,011
DUC WORK FLOW.

4654
02:53:31,011 --> 02:53:34,915
THEY DON'T HAVE NIST COMPLIANCE.

4655
02:53:34,915 --> 02:53:36,150
THAT'S OKAY THEY CAN USE THE 

4656
02:53:36,150 --> 02:53:37,551
DATA IN PLACE.

4657
02:53:37,551 --> 02:53:39,386
THEY JUST CAN'T DOWNLOAD THE 

4658
02:53:39,386 --> 02:53:39,853
DATA.

4659
02:53:39,853 --> 02:53:41,822
HERE IS THE SPLASH PAGE YOU SEE 

4660
02:53:41,822 --> 02:53:42,523
COMING IN.

4661
02:53:42,523 --> 02:53:44,224
IT IS HARD TO TELL, BUT AT THE 

4662
02:53:44,224 --> 02:53:46,126
TOP RIGHT THERE ARE TABS FOR 

4663
02:53:46,126 --> 02:53:48,529
DIFFERENT THINGS.

4664
02:53:48,529 --> 02:53:51,198
TABS FOR ABCD STUDY, HBCD STUDY.

4665
02:53:51,198 --> 02:53:53,567
THAT IS WHERE YOU FIND READ ME 

4666
02:53:53,567 --> 02:53:55,235
DOCS AND THE DATA RELEASES AND 

4667
02:53:55,235 --> 02:53:56,670
MORE INFORMATION ABOUT THE DATA 

4668
02:53:56,670 --> 02:53:58,706
CONTAINED IN THE RELEASES.

4669
02:53:58,706 --> 02:54:00,374
THE DATA ACCESS PROCESS.

4670
02:54:00,374 --> 02:54:01,375
LE DATA TOOLS.

4671
02:54:01,375 --> 02:54:07,648
THAT IS WHERE YOU WILL GO TO 

4672
02:54:07,648 --> 02:54:11,952
ACCESS A WHOLE BUNCH OF FAQs 

4673
02:54:11,952 --> 02:54:13,354
AVAILABLE ON THE FAR RIGHT.

4674
02:54:13,354 --> 02:54:14,855
HERE IS JUST A VISUALIZATION OF 

4675
02:54:14,855 --> 02:54:16,724
THE DATA ACCESS PROCESS.

4676
02:54:16,724 --> 02:54:21,929
THIS IS A SNAPSHOT OF THE FIRST 

4677
02:54:21,929 --> 02:54:23,530
PAGE OF THE TRAINING MODULE.

4678
02:54:23,530 --> 02:54:26,800
A SIGNING OFFICIAL WILL CO-SIGN 

4679
02:54:26,800 --> 02:54:30,104
AFTER A USER SIGNED THEIR DUC.

4680
02:54:30,104 --> 02:54:32,106
DATA ACCESS COMMITTEE DO THEIR 

4681
02:54:32,106 --> 02:54:35,709
REVIEW AND THE USER COMPLETES 

4682
02:54:35,709 --> 02:54:38,879
TRAINING AND THEN THEY HAVE 

4683
02:54:38,879 --> 02:54:39,313
ACCESS TO THE DOITS.

4684
02:54:39,313 --> 02:54:39,580
 -- DATA.

4685
02:54:39,580 --> 02:54:40,814
AND THEN YOU ARE IN.

4686
02:54:40,814 --> 02:54:44,818
THIS IS A SNAPSHOT OF THE VERY 

4687
02:54:44,818 --> 02:54:47,087
HIGH LEVEL QUERY YOU WILL BE 

4688
02:54:47,087 --> 02:54:48,455
ABLE TO DO IMMEDIATELY WHEN YOU 

4689
02:54:48,455 --> 02:54:49,323
COME INTO THE SYSTEM.

4690
02:54:49,323 --> 02:54:51,692
ON THE LEFT IT IS SET TO HBCD 

4691
02:54:51,692 --> 02:54:53,627
RIGHT NOW, BUT, OF COURSE, YOU 

4692
02:54:53,627 --> 02:54:55,095
CAN SEARCH FOR ABCD DATA AS 

4693
02:54:55,095 --> 02:54:55,462
WELL.

4694
02:54:55,462 --> 02:54:57,898
SO YOU CAN DO THINGS LIKE GET A 

4695
02:54:57,898 --> 02:54:59,333
BREAKDOWN BY INSTRUMENT.

4696
02:54:59,333 --> 02:55:00,534
THIS IS NOT REAL DATA.

4697
02:55:00,534 --> 02:55:02,569
THIS IS DUMMY DATA FOR NOW.

4698
02:55:02,569 --> 02:55:04,972
YOU CAN ALSO, FOR EXAMPLE, DO A 

4699
02:55:04,972 --> 02:55:06,640
BREAKDOWN OF PARTICIPANTS PER 

4700
02:55:06,640 --> 02:55:09,877
SESSION OR MODALITY, DIFFERENT 

4701
02:55:09,877 --> 02:55:11,645
IMAGING COMPONENTS.

4702
02:55:11,645 --> 02:55:12,513
OOPS, SORRY.

4703
02:55:12,513 --> 02:55:14,515
AND SO THIS IS JUST VERY QUICK, 

4704
02:55:14,515 --> 02:55:17,184
WITHIN A MATTER OF SECONDS YOU 

4705
02:55:17,184 --> 02:55:19,420
CAN QUICKLY FILTER DOWN YOUR 

4706
02:55:19,420 --> 02:55:21,455
INTERESTED DATA SET TO WHAT YOU 

4707
02:55:21,455 --> 02:55:25,459
MIGHT WANT TO QUERY FURTHER.

4708
02:55:25,459 --> 02:55:30,898
THIS IS THE DATA QUERY COMPONENT

4709
02:55:30,898 --> 02:55:31,932
WHICH IS LASSO SYSTEM.

4710
02:55:31,932 --> 02:55:34,368
YOU CAN DO IT ON THE DEEP WHICH 

4711
02:55:34,368 --> 02:55:38,605
I WILL SHOW YOU AN EXAMPLE IN A 

4712
02:55:38,605 --> 02:55:38,906
MOMENT.

4713
02:55:38,906 --> 02:55:44,812
HERE YOU MIGHT BUILD A DATA 

4714
02:55:44,812 --> 02:55:46,480
QUERY ON RESEARCH DOMAINS AND 

4715
02:55:46,480 --> 02:55:48,916
YOU HAVE A VISUALIZATION OF THE 

4716
02:55:48,916 --> 02:55:53,554
DATA SELECTION ACCORDING TO 

4717
02:55:53,554 --> 02:55:54,088
CRITE

4718
02:55:54,088 --> 02:55:54,354
CRITERIA.

4719
02:55:54,354 --> 02:55:56,990
THIS IS IN A MATTER OF SECONDS.

4720
02:55:56,990 --> 02:55:59,193
IT HAS NICE VISUALIZATIONS.

4721
02:55:59,193 --> 02:56:01,361
YOU CAN SEE WHAT YOU ARE GETTING

4722
02:56:01,361 --> 02:56:02,896
AND TOGGLE BACK AND FORTH.

4723
02:56:02,896 --> 02:56:05,232
THE FINAL COMPONENT IS THE 

4724
02:56:05,232 --> 02:56:07,067
ABILITY TO DOWNLOAD FILE-BASED 

4725
02:56:07,067 --> 02:56:07,301
DATA.

4726
02:56:07,301 --> 02:56:10,771
IF YOU HAVE A PLAN FOR NIST 

4727
02:56:10,771 --> 02:56:11,905
COMPLIANCE, YOU CAN DO THAT.

4728
02:56:11,905 --> 02:56:14,174
I WANTED TO SHOW YOU A SNAPSHOT 

4729
02:56:14,174 --> 02:56:15,242
FROM THE DEEP.

4730
02:56:15,242 --> 02:56:21,381
THIS IS NOT LIVE YET, BUT WILL 

4731
02:56:21,381 --> 02:56:22,916
BE WITH THE LAUNCH OF THE 

4732
02:56:22,916 --> 02:56:23,183
PLATFORM.

4733
02:56:23,183 --> 02:56:28,021
THERE ARE A COUPLE OF WAYS TO 

4734
02:56:28,021 --> 02:56:28,388
QUERY DATA.

4735
02:56:28,388 --> 02:56:31,425
THE FIRST IS A NESTED TREE 

4736
02:56:31,425 --> 02:56:32,926
STRUCTURE.

4737
02:56:32,926 --> 02:56:35,028
ABCD ON THE FAR LEFT AND CORE 

4738
02:56:35,028 --> 02:56:36,130
VERSUS SUB STUDIES.

4739
02:56:36,130 --> 02:56:38,732
SO YOU CAN TOGGLE BACK AND FORTH

4740
02:56:38,732 --> 02:56:40,267
DEPENDING WHERE YOU WANT TO BE 

4741
02:56:40,267 --> 02:56:42,669
AND WHAT MEASURES YOU ARE 

4742
02:56:42,669 --> 02:56:46,173
LOOKING TO QUERY.

4743
02:56:46,173 --> 02:56:48,108
YOU CAN GO DOWN TO THE DATA 

4744
02:56:48,108 --> 02:56:48,542
ELEMENT.

4745
02:56:48,542 --> 02:56:51,778
ON THE RIGHT IS A DETAILED LIST 

4746
02:56:51,778 --> 02:56:52,045
STRUCTURE.

4747
02:56:52,045 --> 02:56:54,348
ANYTHING YOU CLICK ON THE NESTED

4748
02:56:54,348 --> 02:56:57,618
TREE WILL POPULATE AUTOMATICALLY

4749
02:56:57,618 --> 02:56:58,986
TO THE TREE.

4750
02:56:58,986 --> 02:57:00,988
YOU CAN SEARCH THE DETAILED LIST

4751
02:57:00,988 --> 02:57:03,223
AND GET A LOT MORE INFORMATION 

4752
02:57:03,223 --> 02:57:04,158
ABOUT DATA STRUCTURES.

4753
02:57:04,158 --> 02:57:06,460
THERE IS A DETAILS TAB ON THE 

4754
02:57:06,460 --> 02:57:08,595
FAR RIGHT WHICH WILL PROVIDE A 

4755
02:57:08,595 --> 02:57:09,630
LOT OF INFORMATION ABOUT 

4756
02:57:09,630 --> 02:57:12,099
INDIVIDUAL DATA ELEMENTS AND 

4757
02:57:12,099 --> 02:57:14,601
HIGH-LEVEL STATISTICS, SUMMARY 

4758
02:57:14,601 --> 02:57:14,902
STATISTICS.

4759
02:57:14,902 --> 02:57:19,940
AND FINALLY, I THOUGHT I WOULD 

4760
02:57:19,940 --> 02:57:21,575
JUST CONCLUDE THIS WITH COMING 

4761
02:57:21,575 --> 02:57:22,176
SOON.

4762
02:57:22,176 --> 02:57:25,546
A LOT OF THIS IS COMING SOON.

4763
02:57:25,546 --> 02:57:27,548
THIS IS THE PART, SOME ASPECTS 

4764
02:57:27,548 --> 02:57:29,283
WILL BE AVAILABLE IN THE NEXT 

4765
02:57:29,283 --> 02:57:31,084
COUPLE OF MONTHS, OTHERS LATER 

4766
02:57:31,084 --> 02:57:32,920
IN 2025.

4767
02:57:32,920 --> 02:57:34,922
WE'VE DIVIDED THESE DIFFERENT 

4768
02:57:34,922 --> 02:57:36,557
INSTITUTE FUNCTIONALITIES BY 

4769
02:57:36,557 --> 02:57:37,691
USER TIERS.

4770
02:57:37,691 --> 02:57:39,626
ANYONE CAN DO ANY ANALYSES THEY 

4771
02:57:39,626 --> 02:57:40,961
WISH TO DO.

4772
02:57:40,961 --> 02:57:42,829
BUT WE THINK THESE DIFFERENT 

4773
02:57:42,829 --> 02:57:43,931
COMPONENTS REFLECT DIFFERENT 

4774
02:57:43,931 --> 02:57:46,033
NEEDS OF DIFFERENT TYPES OF 

4775
02:57:46,033 --> 02:57:46,233
USERS.

4776
02:57:46,233 --> 02:57:53,407
SO THE DEEP SYSTEM HAS A LOT OF 

4777
02:57:53,407 --> 02:57:58,645
COMPONENTS IN PLACE THAT 

4778
02:57:58,645 --> 02:58:00,180
INCORPORATE THAT MAYBE NOVEL 

4779
02:58:00,180 --> 02:58:01,248
USERS DON'T KNOW AND IT IS BUILT

4780
02:58:01,248 --> 02:58:02,683
IN THERE FOR THEM.

4781
02:58:02,683 --> 02:58:05,819
THAT HAS COMPONENTS, 

4782
02:58:05,819 --> 02:58:07,321
FUNCTIONALITIES FOR CREATION, 

4783
02:58:07,321 --> 02:58:09,256
AND ANALYSIS BUILT IN.

4784
02:58:09,256 --> 02:58:10,857
MORE EXPERIENCE USERS MIGHT WANT

4785
02:58:10,857 --> 02:58:14,928
TO BE COMPUTING IN PLACE IN 

4786
02:58:14,928 --> 02:58:17,164
USING CUSTOMIZED TOOLS FOR DATA 

4787
02:58:17,164 --> 02:58:18,131
EXPLORATION AND ANALYSIS.

4788
02:58:18,131 --> 02:58:24,338
IT IS GOING TO BE A SAND BOX FOR

4789
02:58:24,338 --> 02:58:26,907
DATA ANALYSIS AND COLLABORATION 

4790
02:58:26,907 --> 02:58:28,475
USING TABULATED DATA AS WELL AS 

4791
02:58:28,475 --> 02:58:29,476
FILE-BASED DATA.

4792
02:58:29,476 --> 02:58:31,979
I THINK THE SYSTEM WILL BE BUILT

4793
02:58:31,979 --> 02:58:36,416
TO ACOME DATA UP TO 300 VIRTUAL 

4794
02:58:36,416 --> 02:58:36,617
USERS.

4795
02:58:36,617 --> 02:58:40,220
THE MACHINES WILL SPIN UP AND 

4796
02:58:40,220 --> 02:58:42,756
DOWN DEPENDING ON THE USER 

4797
02:58:42,756 --> 02:58:43,690
NEEDS.

4798
02:58:43,690 --> 02:58:46,593
DEPENDING HOW MUCH COMPUTATIONAL

4799
02:58:46,593 --> 02:58:48,862
POWER ONE NEEDS, MACHINES WILL 

4800
02:58:48,862 --> 02:58:50,597
BE SPUN UP TO ACCOMMODATE.

4801
02:58:50,597 --> 02:58:53,166
THAT IS WHERE I THINK I WILL 

4802
02:58:53,166 --> 02:58:53,634
END.

4803
02:58:53,634 --> 02:58:59,640
HAPPY TO TAKE QUESTIONS IF THERE

4804
02:58:59,640 --> 02:59:01,875
IS TIME.

4805
02:59:01,875 --> 02:59:03,810
MY PERSPECTIVE AND I'M GOING TO 

4806
02:59:03,810 --> 02:59:05,912
RELY ON GEORGE OR NOT.

4807
02:59:05,912 --> 02:59:08,749
IT SAYS HERE 1:25.

4808
02:59:08,749 --> 02:59:10,517
I CUT THE DISCUSSION TO ALMOST 

4809
02:59:10,517 --> 02:59:10,917
NOTHING.

4810
02:59:10,917 --> 02:59:12,919
GEORGE, DO WE HAVE TIME OR 

4811
02:59:12,919 --> 02:59:14,121
SHOULD WE LEAVE THE DISCUSSIONS 

4812
02:59:14,121 --> 02:59:14,521
FOR THE ♪

4813
02:59:14,521 --> 02:59:14,855
♪ 

4814
02:59:14,855 --> 02:59:17,524
>> I THINK WE SHOULD LEAVE
THEM 

4815
02:59:17,524 --> 02:59:19,192
END.

4816
02:59:19,192 --> 02:59:21,528
WE HAVE A LOT OF TIME THERE.

4817
02:59:21,528 --> 02:59:27,067
SO HOLD ALL YOUR QUESTIONS FOR 

4818
02:59:27,067 --> 02:59:29,970
ABCD.

4819
02:59:29,970 --> 02:59:30,704
AND HBCD.

4820
02:59:30,704 --> 02:59:33,807
BECAUSE I WANT TO INTRODUCE DR. 

4821
02:59:33,807 --> 02:59:35,842
HOOD AND GIVE HIM AMPLE TIME TO 

4822
02:59:35,842 --> 02:59:36,877
GIVE WHAT IS GOING TO BE A 

4823
02:59:36,877 --> 02:59:40,614
STELLAR PRESENTATION.

4824
02:59:40,614 --> 02:59:44,651
SO ARE WE GOOD TO GO, NORA?

4825
02:59:44,651 --> 02:59:48,422
IS THAT OKAY?

4826
02:59:48,422 --> 02:59:49,356
ELIZABETH, TERRIFIC 

4827
02:59:49,356 --> 02:59:49,990
PRESENTATION.

4828
02:59:49,990 --> 02:59:50,223
THANKS.

4829
02:59:50,223 --> 02:59:50,924
>> YEAH.

4830
02:59:50,924 --> 02:59:52,793
GREAT PRESENTATIONS FROM ALL OF 

4831
02:59:52,793 --> 02:59:53,894
YOU AND LOOK FORWARD TO A 

4832
02:59:53,894 --> 02:59:56,730
DISCUSSION LATER.

4833
02:59:56,730 --> 02:59:59,132
SO ZRCHLT HOOD IS THE PROMINENT 

4834
02:59:59,132 --> 03:00:01,201
FIGURE IN THE FIELD OF 

4835
03:00:01,201 --> 03:00:03,303
BIOTECHNOLOGY WITH A ROBUST 

4836
03:00:03,303 --> 03:00:05,072
EDUCATIONAL AND PROFESSIONAL 

4837
03:00:05,072 --> 03:00:05,372
BACKGROUND.

4838
03:00:05,372 --> 03:00:08,408
HE EARNED HIS M.D. FROM JOHNS 

4839
03:00:08,408 --> 03:00:09,509
HOPKINS UNIVERSITY AND A PH.D. 

4840
03:00:09,509 --> 03:00:11,611
IN BIOCHEMISTRY FROM THE 

4841
03:00:11,611 --> 03:00:13,747
CALIFORNIA INSTITUTE OF 

4842
03:00:13,747 --> 03:00:14,915
TECHNOLOGY, WE CALL IN 

4843
03:00:14,915 --> 03:00:16,149
CALIFORNIA CAL TECH.

4844
03:00:16,149 --> 03:00:18,919
HIS SIGNIFICANT CAREER BEGAN IN 

4845
03:00:18,919 --> 03:00:21,455
1967 AS A SENIOR INVESTIGATOR AT

4846
03:00:21,455 --> 03:00:23,990
THE NATIONAL CANCER INSTITUTE AT

4847
03:00:23,990 --> 03:00:25,058
NIH.

4848
03:00:25,058 --> 03:00:32,032
DR. HOOD HAS HELD NUMEROUS 

4849
03:00:32,032 --> 03:00:32,866
PRESTIGIOUS POSITIONS FACULTY 

4850
03:00:32,866 --> 03:00:35,969
CHAIRMAN OF BIOLOGY AT CAL TECH,

4851
03:00:35,969 --> 03:00:38,538
FOUNDER AND CHAIRMAN OF 

4852
03:00:38,538 --> 03:00:39,740
BIOMEDICAL TECHNOLOGY AT THE 

4853
03:00:39,740 --> 03:00:41,174
UNIVERSITY OF WASHINGTON MEDICAL

4854
03:00:41,174 --> 03:00:43,610
SCHOOL AND THE INSTITUTE FOR 

4855
03:00:43,610 --> 03:00:46,313
SYSTEMS BIOLOGY KNOWN AS ISB.

4856
03:00:46,313 --> 03:00:49,249
DR. HOOD'S SIGN IFFIC 

4857
03:00:49,249 --> 03:00:50,117
CONTRIBUTIONS ARE 

4858
03:00:50,117 --> 03:00:51,184
GROUNDBREAKING.

4859
03:00:51,184 --> 03:00:52,619
RENOWNED FOR DEVELOPMENT OF 

4860
03:00:52,619 --> 03:00:54,488
AUTOMATED DNA SEQUENCES, WHICH 

4861
03:00:54,488 --> 03:00:58,258
WAS PIVOTAL IN THE HUMAN GENOME 

4862
03:00:58,258 --> 03:00:58,492
PROJECT.

4863
03:00:58,492 --> 03:01:00,360
ADDITIONALLY HE PLAYED A KEY 

4864
03:01:00,360 --> 03:01:03,130
ROLE IN THE INVENTION OF THE 

4865
03:01:03,130 --> 03:01:06,933
SYNTHESIZER AND SEQUENCER AND 

4866
03:01:06,933 --> 03:01:11,405
THE INK JET DNA SYNTHESIZER THAT

4867
03:01:11,405 --> 03:01:12,606
ADVANCED MEDICAL RESEARCH AND 

4868
03:01:12,606 --> 03:01:15,108
MEDICAL DIAGNOSTICS.

4869
03:01:15,108 --> 03:01:19,212
HE HELPED DECIPHER THE IMMUNE 

4870
03:01:19,212 --> 03:01:19,980
DIVERSITY.

4871
03:01:19,980 --> 03:01:21,648
PIONEERED SYSTEMS APPROACHES TO 

4872
03:01:21,648 --> 03:01:23,150
BLOLG AND DISEASE.

4873
03:01:23,150 --> 03:01:27,020
HE INITIATED THE FIRST EFFORTS 

4874
03:01:27,020 --> 03:01:29,790
TO STUDY INDIVIDUAL GENOME AND 

4875
03:01:29,790 --> 03:01:31,658
FEE HOME ANALYSIS OF POPULATIONS

4876
03:01:31,658 --> 03:01:35,028
WHICH LED TO THE CONCEPT OF 

4877
03:01:35,028 --> 03:01:36,530
DATA-DRIVEN HEALTH.

4878
03:01:36,530 --> 03:01:38,865
DR. HOOD IS ON PIONEER SYSTEMS 

4879
03:01:38,865 --> 03:01:40,700
TO UNDERSTAND THE COMPLEXITY OF 

4880
03:01:40,700 --> 03:01:42,569
BIOLOGICAL SYSTEMS IN HUMANS.

4881
03:01:42,569 --> 03:01:46,206
HIS WORK AT ISB AND THE PHENOME 

4882
03:01:46,206 --> 03:01:48,975
HEALTH, A NONPROFIT HE FOUNDED, 

4883
03:01:48,975 --> 03:01:53,380
AND ACTS AS A CEO, INVOLVES 

4884
03:01:53,380 --> 03:01:56,349
INTEGRATING BIOLOGY, TECHNOLOGY,

4885
03:01:56,349 --> 03:01:57,617
COMPUTATION AND ARTIFICIAL 

4886
03:01:57,617 --> 03:02:00,053
INTELLIGENCE TO DECODE THE 

4887
03:02:00,053 --> 03:02:01,988
GENOMIC BASIS OF HEALTH AND 

4888
03:02:01,988 --> 03:02:02,222
DISEASE.

4889
03:02:02,222 --> 03:02:04,591
HIS TEAM IS WORKING ON 

4890
03:02:04,591 --> 03:02:06,460
PERSONALIZED MEDICINE AIMING TO 

4891
03:02:06,460 --> 03:02:09,930
HEALTH CARE BASED ON INDIVIDUAL 

4892
03:02:09,930 --> 03:02:12,799
GENOME AND LONGITUDINAL PHENOME 

4893
03:02:12,799 --> 03:02:14,668
ANALYSIS ENABLING HEALTH CARE 

4894
03:02:14,668 --> 03:02:16,336
FOCUSED ON OPTIMIZING WELLNESS 

4895
03:02:16,336 --> 03:02:18,572
AND EARLY DETECTION AND THE 

4896
03:02:18,572 --> 03:02:19,139
PREVENTION OF DISEASE.

4897
03:02:19,139 --> 03:02:21,475
HE IS A MEMBER OF ALL THREE 

4898
03:02:21,475 --> 03:02:22,909
NATIONAL ACADEMIES.

4899
03:02:22,909 --> 03:02:27,113
HE RECEIVED THE LASKER AWARD IN 

4900
03:02:27,113 --> 03:02:30,584
1987 FOR DECIPHERING IMMUNE 

4901
03:02:30,584 --> 03:02:32,786
DIVERSITY AND THE NATIONAL 

4902
03:02:32,786 --> 03:02:34,120
MEDICINE OF SCIENCE FROM 

4903
03:02:34,120 --> 03:02:37,357
PRESIDENT OBAMA IN 2011.

4904
03:02:37,357 --> 03:02:38,558
LOOKING AHEAD, DR. HOOD'S 

4905
03:02:38,558 --> 03:02:40,827
RESEARCH IS DIRECTED TOWARD THE 

4906
03:02:40,827 --> 03:02:41,561
FUTURE OF HEALTH CARE THROUGH 

4907
03:02:41,561 --> 03:02:47,400
THE CONCEPT OF P-4 MEDICINE, 

4908
03:02:47,400 --> 03:02:50,837
PREDICTIVE, PREVENTIVE, 

4909
03:02:50,837 --> 03:02:53,206
PERSONALIZED AND PARTICIPATORY.

4910
03:02:53,206 --> 03:02:55,141
LEVERAGING BIG DATA SYSTEMS 

4911
03:02:55,141 --> 03:02:56,877
ANALYSIS, AI AND A NEW STRATEGY 

4912
03:02:56,877 --> 03:03:01,081
FOR RAPIDLY AND INEXPENSIVELY 

4913
03:03:01,081 --> 03:03:01,915
GENERATING DRUGS TO TRANSFORM 

4914
03:03:01,915 --> 03:03:03,683
HEALTH CARE MAKING IT MORE 

4915
03:03:03,683 --> 03:03:05,652
EFFICIENT AND EFFECTIVE BY 

4916
03:03:05,652 --> 03:03:08,622
PREDICTING DISEASE, PREVENTING 

4917
03:03:08,622 --> 03:03:10,123
IT, PERSONALIZING TREATMENT AND 

4918
03:03:10,123 --> 03:03:13,727
INVOLVING PATIENTS IN THEIR OWN 

4919
03:03:13,727 --> 03:03:14,294
CARE.

4920
03:03:14,294 --> 03:03:16,930
HE'S ADVOCATED AND EXTENSION OF 

4921
03:03:16,930 --> 03:03:19,866
THE HUMAN GENOME PROJECT, KNOWN 

4922
03:03:19,866 --> 03:03:23,570
AS THE HUMAN PHENOME INITIATIVE,

4923
03:03:23,570 --> 03:03:25,805
SUGGESTING THE ANALYSIS OF 1 

4924
03:03:25,805 --> 03:03:28,241
MILLION INDIVIDUALS OVER A 

4925
03:03:28,241 --> 03:03:30,243
PERIOD OF FIVE TO 10 YEARS.

4926
03:03:30,243 --> 03:03:32,078
DR. HOOD, WE ARE REALLY LOOKING 

4927
03:03:32,078 --> 03:03:32,846
FORWARD TO YOUR TALK.

4928
03:03:32,846 --> 03:03:40,520
THE TITLE IS THE SYNERGY OF 

4929
03:03:40,520 --> 03:03:44,090
DATA-DRIVEN HEALTH

4930
03:03:44,090 --> 03:03:44,624
DATA-DRIVEN INFORMATIONAL 

4931
03:03:44,624 --> 03:03:45,392
PEPTIDE DRUG DISCOVERY IN 

4932
03:03:45,392 --> 03:03:46,026
DEALING WITH DATA-DRIVEN HEALTH 

4933
03:03:46,026 --> 03:03:46,660
CARHEALTH AND A UNIVERSAL N = 1 

4934
03:03:46,660 --> 03:03:46,960
HEALTH CARE.

4935
03:03:46,960 --> 03:03:48,128
IT IS ALL YOURS, SIR.

4936
03:03:48,128 --> 03:03:48,828
>> OKAY.

4937
03:03:48,828 --> 03:03:50,130
THANK YOU VERY MUCH.

4938
03:03:50,130 --> 03:03:55,969
WELL, LET'S SEE IF WE CAN GET 

4939
03:03:55,969 --> 03:03:56,536
ON.

4940
03:03:56,536 --> 03:03:57,637
I HAVE TROUBLE WHERE MICROSOFT 

4941
03:03:57,637 --> 03:03:57,837
TEAMS.

4942
03:03:57,837 --> 03:03:59,072
I MUST SAY.

4943
03:03:59,072 --> 03:04:01,041
I NEED PERMISSION TO SHARE MY 

4944
03:04:01,041 --> 03:04:01,274
SCREEN.

4945
03:04:01,274 --> 03:04:07,714
CAN SOMEONE GIVE ME PERMISSION?

4946
03:04:07,714 --> 03:04:11,117
>> YES, GIVE US A FEW
SECONDS.

4947
03:04:11,117 --> 03:04:12,419
>> PHILIPPE IS DOING THAT
RIGHT 

4948
03:04:12,419 --> 03:04:12,719
NOW.

4949
03:04:12,719 --> 03:04:23,063
YOU ARE GOOD TO GO.

4950
03:04:26,199 --> 03:04:29,803
I STILL SEE I NEED PERMISSION.

4951
03:04:29,803 --> 03:04:31,805
I HOPE TO GOD YOU DON'T HAVE TO 

4952
03:04:31,805 --> 03:04:37,644
ADVANCE THE SLIDES.

4953
03:04:37,644 --> 03:04:39,479
IT'S NOT LETTING ME IN.

4954
03:04:39,479 --> 03:04:39,980
>> YEAH.

4955
03:04:39,980 --> 03:04:40,547
WE KNOW.

4956
03:04:40,547 --> 03:04:49,456
WE ARE WORKING ON IT HERE.

4957
03:04:49,456 --> 03:04:55,528
PHILIPPE.

4958
03:04:55,528 --> 03:04:58,932
CHRIS, IS THERE A WAY YOU CAN 

4959
03:04:58,932 --> 03:05:00,867
PUT THESE UP?

4960
03:05:00,867 --> 03:05:04,137
>> THERE IS, BUT IT IS A
LOT OF 

4961
03:05:04,137 --> 03:05:04,404
ADVANCES.

4962
03:05:04,404 --> 03:05:06,906
I WOULD LIKE TO DO IT MYSELF IF 

4963
03:05:06,906 --> 03:05:11,411
WE CAN.

4964
03:05:11,411 --> 03:05:16,750
>> WE'RE TRYING TO DO IT.

4965
03:05:16,750 --> 03:05:18,151
HE'S OUTSIDE OF THE 

4966
03:05:18,151 --> 03:05:19,119
ORGANIZATION, PHILIPPE.

4967
03:05:19,119 --> 03:05:29,496
IS THERE SOME WAY -- 

4968
03:05:30,497 --> 03:05:31,665
>> DO YOU WANT TO TRY
AGAIN.

4969
03:05:31,665 --> 03:05:37,504
>> OKAY.

4970
03:05:37,504 --> 03:05:38,571
>> TRY AGAIN.

4971
03:05:38,571 --> 03:05:38,805
>> NOPE.

4972
03:05:38,805 --> 03:05:47,414
SAME THING.

4973
03:05:47,414 --> 03:05:49,849
>> WELL I'M HAPPY TO
ADVANCE -- 

4974
03:05:49,849 --> 03:05:51,751
>> WE CAN GO TO YOU
SHOWING MY 

4975
03:05:51,751 --> 03:05:56,322
SLIDES.

4976
03:05:56,322 --> 03:05:59,559
LET'S SEE IF THIS DOES IT.

4977
03:05:59,559 --> 03:06:02,896
>> THERE WE GO.

4978
03:06:02,896 --> 03:06:06,533
>> YOU THINK SO?

4979
03:06:06,533 --> 03:06:15,175
>> IT WAS THERE.

4980
03:06:15,175 --> 03:06:17,544
>> NOW I SEE NOTHING --
OH.

4981
03:06:17,544 --> 03:06:18,545
>> DO YOU SEE IT?

4982
03:06:18,545 --> 03:06:19,212
>> I DON'T SEE IT.

4983
03:06:19,212 --> 03:06:22,082
NO.

4984
03:06:22,082 --> 03:06:22,415
>> WE SEE IT.

4985
03:06:22,415 --> 03:06:24,317
>> OH, I SEE IT NOW.

4986
03:06:24,317 --> 03:06:25,251
>> OKAY.

4987
03:06:25,251 --> 03:06:29,889
THERE'S PROBABLY A DELAY.

4988
03:06:29,889 --> 03:06:30,090
OKAY.

4989
03:06:30,090 --> 03:06:40,600
WE'RE READY TO GO IF YOU ARE.

4990
03:06:50,310 --> 03:06:54,447
>> LEE, CAN YOU ADVANCE?

4991
03:06:54,447 --> 03:06:59,352
>> WE LOST HIM.

4992
03:06:59,352 --> 03:07:06,726
NOW WHAT?

4993
03:07:06,726 --> 03:07:09,496
>> CHRIS, CAN YOU SEE IF
HE IS 

4994
03:07:09,496 --> 03:07:09,863
STILL ON.

4995
03:07:09,863 --> 03:07:11,598
>> CAN YOU SEE THE SLIDES?

4996
03:07:11,598 --> 03:07:13,900
I CAN SEE SOMETHING NOW.

4997
03:07:13,900 --> 03:07:15,802
>> WE CAN SEE THE SLIDES.

4998
03:07:15,802 --> 03:07:16,736
CAN YOU HEAR US?

4999
03:07:16,736 --> 03:07:18,037
>> I CAN HEAR YOU FINE.

5000
03:07:18,037 --> 03:07:18,905
CAN YOU HEAR ME?

5001
03:07:18,905 --> 03:07:20,507
>> YES.

5002
03:07:20,507 --> 03:07:23,810
SO IF YOU CAN ADVANCE, WE'RE 

5003
03:07:23,810 --> 03:07:25,145
READY TO GO.

5004
03:07:25,145 --> 03:07:25,545
>> OKAY.

5005
03:07:25,545 --> 03:07:27,714
>> TRY ADVANCING.

5006
03:07:27,714 --> 03:07:28,882
YEAH.

5007
03:07:28,882 --> 03:07:29,215
THAT WORKED.

5008
03:07:29,215 --> 03:07:38,925
>> LET'S SEE.

5009
03:07:38,925 --> 03:07:39,826
LET'S GO BACK TO -- 

5010
03:07:39,826 --> 03:07:44,063
>> THAT'S THE TITLE PAGE.

5011
03:07:44,063 --> 03:07:46,099
>> WELL, LET ME MAKE THREE

5012
03:07:46,099 --> 03:07:52,672
COMMENTS BEFORE I GET STARTED 

5013
03:07:52,672 --> 03:07:53,406
THEN.

5014
03:07:53,406 --> 03:07:54,974
ONE, I SEE HEALTH IS THREE 

5015
03:07:54,974 --> 03:07:56,376
DIFFERENT STAGES.

5016
03:07:56,376 --> 03:07:58,344
ONE IS OPT MISZING WELLNESS, THE

5017
03:07:58,344 --> 03:08:01,581
SECOND IS DEALING WITH FRANK 

5018
03:08:01,581 --> 03:08:05,084
DISEASE, DIAGNOSED DISEASE AND 

5019
03:08:05,084 --> 03:08:07,320
THE THIRD IS BEING ABLE TO 

5020
03:08:07,320 --> 03:08:09,589
DEFECT VERY EARLY AND REVERSE 

5021
03:08:09,589 --> 03:08:11,558
WELLNESS TO DISEASE TRANSITIONS.

5022
03:08:11,558 --> 03:08:14,928
AND THOSE THREE THINGS I THINK 

5023
03:08:14,928 --> 03:08:16,329
MAP INTO THE THREE DIFFERENT 

5024
03:08:16,329 --> 03:08:18,198
MAJOR AREAS THAT WE'RE TALKING 

5025
03:08:18,198 --> 03:08:20,400
ABOUT IN THIS DIFFERENT MEETING.

5026
03:08:20,400 --> 03:08:22,268
I THINK A SECOND THING THAT IS 

5027
03:08:22,268 --> 03:08:23,636
REALLY IMPORTANT IS THERE WAS A 

5028
03:08:23,636 --> 03:08:26,272
RECENT PAPER OUT OF STANFORD 

5029
03:08:26,272 --> 03:08:30,009
THAT SHOWED WITH REGARD TO 

5030
03:08:30,009 --> 03:08:36,316
HEALTH ABOUT 89% OF IT IS 

5031
03:08:36,316 --> 03:08:39,719
PHENOMIC IN NATURE, 11% IS 

5032
03:08:39,719 --> 03:08:39,986
GENOMIC.

5033
03:08:39,986 --> 03:08:41,988
THE VAST BULK OF DEALING WITH 

5034
03:08:41,988 --> 03:08:44,157
WELLNESS AND DISEASE IS YOUR 

5035
03:08:44,157 --> 03:08:46,593
BEHAVIOR AND THE ENVIRONMENT IN 

5036
03:08:46,593 --> 03:08:47,827
WHICH YOU LIVE.

5037
03:08:47,827 --> 03:08:53,900
THE TWO MAJOR ELEMENTS TO 

5038
03:08:53,900 --> 03:08:54,267
PHENOMICS.

5039
03:08:54,267 --> 03:08:56,269
A THIRD CATEGORY OF THE WHOLE 

5040
03:08:56,269 --> 03:08:58,338
IDEA OF TELLING YOU ABOUT 

5041
03:08:58,338 --> 03:08:59,472
DATA-DRIVEN HEALTH AND WHAT IT 

5042
03:08:59,472 --> 03:09:03,443
IS AND HOW IT IS GOING TO 

5043
03:09:03,443 --> 03:09:07,680
ABSOLUTELY MAN DAVID A 

5044
03:09:07,680 --> 03:09:08,948
DATA-DRIVEN INFORMATIONAL 

5045
03:09:08,948 --> 03:09:10,950
PEPTIDE DISCOVERY.

5046
03:09:10,950 --> 03:09:14,120
BECAUSE WE WILL NEED A WHOLE NEW

5047
03:09:14,120 --> 03:09:21,461
APPROACH FOR DRUG DISCOVERY.

5048
03:09:21,461 --> 03:09:27,367
SO NOW IT IS NOT ADVANCING.

5049
03:09:27,367 --> 03:09:29,235
>> I WILL HAVE TO ADVANCE
THE 

5050
03:09:29,235 --> 03:09:30,503
SLIDES FOR YOU, UNFORTUNATELY.

5051
03:09:30,503 --> 03:09:32,205
SO IF YOU CAN SAY NEXT SLIDE.

5052
03:09:32,205 --> 03:09:34,040
>> OKAY.

5053
03:09:34,040 --> 03:09:37,143
I'LL JUST SAY NEXT.

5054
03:09:37,143 --> 03:09:37,443
OKAY.

5055
03:09:37,443 --> 03:09:45,084
SO WHAT I WANT TO SAY AS AN 

5056
03:09:45,084 --> 03:09:47,787
ASSISTANT PROFESSOR IN 1960, I 

5057
03:09:47,787 --> 03:09:49,589
WAS INTERESTED IN HUMAN 

5058
03:09:49,589 --> 03:09:50,023
COMPLEXITY.

5059
03:09:50,023 --> 03:09:51,991
THAT LED ME TO REALIZE AT THAT 

5060
03:09:51,991 --> 03:09:53,559
TIME THERE WERE TWO MAJOR 

5061
03:09:53,559 --> 03:09:56,696
ASPECTS OF DEALING WITH HUMAN 

5062
03:09:56,696 --> 03:09:57,196
COMPLEXITY.

5063
03:09:57,196 --> 03:10:00,700
ONE WE NEEDED TO GENERATE THE 

5064
03:10:00,700 --> 03:10:02,068
TECHNOLOGIES NECESSARY FOR 

5065
03:10:02,068 --> 03:10:04,570
GENERATING BIG DATA BECAUSE IN 

5066
03:10:04,570 --> 03:10:06,873
THE END COMPLEXITY MUST BE 

5067
03:10:06,873 --> 03:10:09,042
SOLVED BY ENORMOUS AMOUNTS OF 

5068
03:10:09,042 --> 03:10:11,544
DATA FROM INDIVIDUALS.

5069
03:10:11,544 --> 03:10:13,546
AND NUMBER TWO, IT WAS QUITE 

5070
03:10:13,546 --> 03:10:15,248
CLEAR YOU HAD TO BE ABLE TO DO 

5071
03:10:15,248 --> 03:10:16,916
SOMETHING WITH THAT DATA AND 

5072
03:10:16,916 --> 03:10:19,852
THAT WAS WHERE THE BEGINNING OF 

5073
03:10:19,852 --> 03:10:22,188
SYSTEMS BIOLOGY EMERGED.

5074
03:10:22,188 --> 03:10:23,456
PLEASE DON'T ADVANCE UNTIL I 

5075
03:10:23,456 --> 03:10:27,093
TELL YOU TO CLICK.

5076
03:10:27,093 --> 03:10:27,293
OKAY.

5077
03:10:27,293 --> 03:10:29,662
SO THE FIRST SERIES OF PARADIGM 

5078
03:10:29,662 --> 03:10:34,167
CHANGES I WAS INVOLVED IN WAS 

5079
03:10:34,167 --> 03:10:35,635
THIS IDEA OF DEVELOPING OVER A 

5080
03:10:35,635 --> 03:10:40,340
PERIOD OF 25 YEARS SIX DIFFERENT

5081
03:10:40,340 --> 03:10:42,408
INSTRUMENTS FOR ESSENTIALLY 

5082
03:10:42,408 --> 03:10:44,410
ANALYZING DNA AND ANALYZING, 

5083
03:10:44,410 --> 03:10:53,086
WELL, DNA RNA AND PROTEINS.

5084
03:10:53,086 --> 03:10:55,922
ONE OF THE INCIDENTS ON THE NEXT

5085
03:10:55,922 --> 03:10:56,122
CLICK.

5086
03:10:56,122 --> 03:10:58,791
COULD YOU ADVANCE IT.

5087
03:10:58,791 --> 03:11:01,794
IN THE SPRING OF 1985, CAN YOU 

5088
03:11:01,794 --> 03:11:06,866
ADVANCE THE SLIDE, PLEASE?

5089
03:11:06,866 --> 03:11:07,133
THANK YOU.

5090
03:11:07,133 --> 03:11:10,570
OF WHEN 12 OF US GOT TOGETHER 

5091
03:11:10,570 --> 03:11:13,973
AND DECIDED THAT ONE, IT WAS 

5092
03:11:13,973 --> 03:11:16,275
FEASIBLE TO DO THE GENOME 

5093
03:11:16,275 --> 03:11:19,612
PROJECT AND, TWO, WE WERE SPLIT 

5094
03:11:19,612 --> 03:11:19,779
6-6.

5095
03:11:19,779 --> 03:11:22,548
THOSE OPPOSING IT WERE AGAINST 

5096
03:11:22,548 --> 03:11:24,450
IT BECAUSE IT WAS BIG SCIENCE 

5097
03:11:24,450 --> 03:11:27,286
AND THEY WERE AFRAID IT WOULD 

5098
03:11:27,286 --> 03:11:28,087
DESTROY SCIENCE.

5099
03:11:28,087 --> 03:11:33,626
OF COURSE, THE HUMAN GENOME 

5100
03:11:33,626 --> 03:11:36,629
PROJECT IN 2003 GAVE US THE 

5101
03:11:36,629 --> 03:11:40,700
ABILITY FOR EACH INDIVIDUAL TO 

5102
03:11:40,700 --> 03:11:42,268
FRAME YOUR POTENTIAL HEALTH 

5103
03:11:42,268 --> 03:11:42,568
TRAJECTORY.

5104
03:11:42,568 --> 03:11:45,304
I WILL SAY MORE ABOUT THAT 

5105
03:11:45,304 --> 03:11:45,805
LATER.

5106
03:11:45,805 --> 03:11:47,340
THE THIRD PARADIGM CHANGE ON THE

5107
03:11:47,340 --> 03:11:50,676
NEXT SLIDE THAT CAME UP WAS THAT

5108
03:11:50,676 --> 03:11:52,612
I PROPOSED THAT CAL TECH THE 

5109
03:11:52,612 --> 03:11:54,814
IDEA OF CREATING -- COULD WE 

5110
03:11:54,814 --> 03:12:02,588
HAVE THE NEXT SLIDE, PLEASE.

5111
03:12:02,588 --> 03:12:05,358
CREATING A CROSS DISCIPLINARY 

5112
03:12:05,358 --> 03:12:06,559
DEPARTMENT RATHER THAN HAVING A 

5113
03:12:06,559 --> 03:12:08,694
BIG LAB AS I DID WITH ALL THE 

5114
03:12:08,694 --> 03:12:10,530
DIFFERENT TECHNOLOGIES.

5115
03:12:10,530 --> 03:12:12,999
AND CAL TECH BIOLOGY TURNED THAT

5116
03:12:12,999 --> 03:12:14,233
DOWN, BUT BILL GATES MADE IT 

5117
03:12:14,233 --> 03:12:16,369
POSSIBLE TO GO TO THE UNIVERSITY

5118
03:12:16,369 --> 03:12:19,439
OF WASHINGTON TO START MOLECULAR

5119
03:12:19,439 --> 03:12:19,806
BIOTECHNOLOGY.

5120
03:12:19,806 --> 03:12:25,578
AND IN EIGHT YEARS, REALLY, IT 

5121
03:12:25,578 --> 03:12:28,581
CREATED THE SOFTWARE FOR JOIN 

5122
03:12:28,581 --> 03:12:31,651
HUMAN GENOME PROJECT, PHIL GREEN

5123
03:12:31,651 --> 03:12:34,187
FOR ASSEMBLY AND QUALITY 

5124
03:12:34,187 --> 03:12:34,554
CONTROL.

5125
03:12:34,554 --> 03:12:39,759
RUDY ABERSOL AND JOHN GATES LED 

5126
03:12:39,759 --> 03:12:42,895
THE PEOPLE IN PROTEOMICS.

5127
03:12:42,895 --> 03:12:49,302
AND WE DEVELOPED THE INK JET 

5128
03:12:49,302 --> 03:12:51,237
TECHNOLOGY IN THE SYNTHESIS OF 

5129
03:12:51,237 --> 03:12:53,840
PEPTIDE DRUGS AND SO FORTH.

5130
03:12:53,840 --> 03:12:57,677
IN 2000, I RESIGNED FROM 

5131
03:12:57,677 --> 03:12:58,678
UNIVERSITY OF WASHINGTON AND 

5132
03:12:58,678 --> 03:13:01,747
STARTED ON THE NEXT SLIDE THE 

5133
03:13:01,747 --> 03:13:04,884
INSTITUTE FOR SYSTEMS BIOLOGY 

5134
03:13:04,884 --> 03:13:06,085
WAS THE FIRST ORGANIZATION FOR 

5135
03:13:06,085 --> 03:13:07,253
SYSTEMS APPROACHES.

5136
03:13:07,253 --> 03:13:09,622
NEXT SLIDE, PLEASE.

5137
03:13:09,622 --> 03:13:12,692
>> LEE, THERE IS A BIT OF
A 

5138
03:13:12,692 --> 03:13:13,092
DELAY.

5139
03:13:13,092 --> 03:13:15,361
>> OKAY.

5140
03:13:15,361 --> 03:13:17,630
I'LL JUST TALK.

5141
03:13:17,630 --> 03:13:18,364
FINE.

5142
03:13:18,364 --> 03:13:20,700
AND SYSTEMS BIOLOGY, WHAT WE DID

5143
03:13:20,700 --> 03:13:25,104
WAS TO REALLY PIONEER FIRST AN 

5144
03:13:25,104 --> 03:13:28,374
APPROACH TO NORMAL BIOLOGY WHERE

5145
03:13:28,374 --> 03:13:35,648
TREY IDIGER AS A GRADUATE 

5146
03:13:35,648 --> 03:13:37,884
STUDENT DID -- SHOWING 

5147
03:13:37,884 --> 03:13:39,585
BEAUTIFULLY WE COULD MAP IT INTO

5148
03:13:39,585 --> 03:13:42,588
NETWORKS AND DYNAMICS AND 

5149
03:13:42,588 --> 03:13:53,065
EXPLAIN THE PHYSIOLOGY OF s 

5150
03:14:26,499 --> 03:14:27,200
utilizaUtah

5151
03:14:27,500 --> 03:14:35,775
Utahly  we suggested the idea of

5152
03:14:35,775 --> 03:14:36,576
P4 health care.

5153
03:14:36,576 --> 03:14:38,878
The essence of that describes 

5154
03:14:38,878 --> 03:14:40,680
the ideal features of health 

5155
03:14:40,680 --> 03:14:42,615
care in contrast to precision 

5156
03:14:42,615 --> 03:14:45,051
medicine which is a focused 

5157
03:14:45,051 --> 03:14:46,419
effort on one very small 

5158
03:14:46,419 --> 03:14:49,822
component, usually a single 

5159
03:14:49,822 --> 03:14:56,128
protein or regulatory element or

5160
03:14:56,128 --> 03:14:56,462
so.

5161
03:14:56,462 --> 03:14:57,496
And what happened next was 

5162
03:14:57,496 --> 03:14:58,998
really interesting.

5163
03:14:58,998 --> 03:15:04,103
On the next slide, I was able to

5164
03:15:04,103 --> 03:15:07,173
persuade the grand dutchy of LUX

5165
03:15:07,173 --> 03:15:11,644
EM borge to provide $100 million

5166
03:15:11,644 --> 03:15:14,146
over a five-year period to 

5167
03:15:14,146 --> 03:15:15,581
explore all of the technologies 

5168
03:15:15,581 --> 03:15:18,217
and strategies we needed to 

5169
03:15:18,217 --> 03:15:25,591
carry out systems approached to 

5170
03:15:25,591 --> 03:15:35,768
medicine.

5171
03:16:06,832 --> 03:16:17,310
I was offered I found the modern

5172
03:16:19,879 --> 03:16:22,248
bureaucracies essentially make 

5173
03:16:22,248 --> 03:16:25,284
them imbracket KL for new ideas.

5174
03:16:25,284 --> 03:16:28,220
In 21 I re-signed and started 

5175
03:16:28,220 --> 03:16:30,456
phenome health and used that to 

5176
03:16:30,456 --> 03:16:32,391
drive this idea of data-driven 

5177
03:16:32,391 --> 03:16:34,460
health which has led to the idea

5178
03:16:34,460 --> 03:16:44,970
of a million person project I 

5179
03:17:09,495 --> 03:17:11,630
will talk about that at the end 

5180
03:17:11,630 --> 03:17:12,665
of my discussion.

5181
03:17:12,665 --> 03:17:14,300
This really has led me on the 

5182
03:17:14,300 --> 03:17:16,602
next slide to the conviction 

5183
03:17:16,602 --> 03:17:19,705
that 7 out of 8 of these 

5184
03:17:19,705 --> 03:17:24,677
paradigm changes, genome project

5185
03:17:24,677 --> 03:17:28,114
in part were cat LIZed by small 

5186
03:17:28,114 --> 03:17:29,548
and agile institutions.

5187
03:17:29,548 --> 03:17:31,550
On the next click, they could be

5188
03:17:31,550 --> 03:17:33,586
nonprofits and I did a number of

5189
03:17:33,586 --> 03:17:37,323
nonprofits that contributed to 

5190
03:17:37,323 --> 03:17:39,258
these or they could be for 

5191
03:17:39,258 --> 03:17:40,726
profits and likewise on the next

5192
03:17:40,726 --> 03:17:42,895
click I did a number of for 

5193
03:17:42,895 --> 03:17:53,038
profits.

5194
03:17:53,806 --> 03:17:56,142
They rarely come from large 

5195
03:17:56,142 --> 03:17:57,376
organizations because of 

5196
03:17:57,376 --> 03:18:07,820
bureaucratic constraints.

5197
03:18:53,632 --> 03:18:55,734
OUTCOME OF DATA DRIVEN HEALTH 

5198
03:18:55,734 --> 03:18:58,070
CREATES US A SPAN TO MOVE INTO 

5199
03:18:58,070 --> 03:19:01,106
THE 90s AND 100s.

5200
03:19:01,106 --> 03:19:06,712
THE DATA DRIVEN HEALTH HAS TWO 

5201
03:19:06,712 --> 03:19:08,280
COMPONENTS, THE GENOME IT GIVES 

5202
03:19:08,280 --> 03:19:09,882
YOU A FRAMING OF POTENTIAL 

5203
03:19:09,882 --> 03:19:11,717
HEALTH TRAJECTORY AND ON THE 

5204
03:19:11,717 --> 03:19:14,587
NEXT SLIDE, THE ABILITY TO 

5205
03:19:14,587 --> 03:19:16,889
ASSESS FROM BIRTH TO DEATH THE 

5206
03:19:16,889 --> 03:19:18,023
ACTUAL TRAJECTORY THAT YOU 

5207
03:19:18,023 --> 03:19:18,891
ACTUALLY TAKE.

5208
03:19:18,891 --> 03:19:22,495
AND ON THE NEXT SLIDE, YOU CAN 

5209
03:19:22,495 --> 03:19:29,335
SEE FOLLOWING THESE DIVERSE 

5210
03:19:29,335 --> 03:19:32,571
PHENO TYPES AS YOU CHANGE FROM 

5211
03:19:32,571 --> 03:19:33,339
BIRTH TO DEATH.

5212
03:19:33,339 --> 03:19:40,079
NEXT SLIDE, PLEASE.

5213
03:19:40,079 --> 03:19:42,248
ALLOWS YOU TO -- AND THEY ARE 

5214
03:19:42,248 --> 03:19:43,983
ACTIVATED BY TWO DIFFERENT 

5215
03:19:43,983 --> 03:19:44,283
ASPECTS.

5216
03:19:44,283 --> 03:19:47,453
ONE IS BEHAVIOR AND ONE IS 

5217
03:19:47,453 --> 03:19:47,753
ENVIRONMENT.

5218
03:19:47,753 --> 03:19:50,589
AND FROM THE PHENOMICS ON THE 

5219
03:19:50,589 --> 03:19:54,894
NEXT CLICK, WE CAN DO MULTIOMIC 

5220
03:19:54,894 --> 03:20:03,869
DATA ANALYSIS OF BLOOD ANALYZE.

5221
03:20:03,869 --> 03:20:07,973
THE GUT BIOME AND SO FORTH FT 

5222
03:20:07,973 --> 03:20:10,309
ANYTHING THAT CHANGES IN 

5223
03:20:10,309 --> 03:20:11,710
INFORMATIONAL MOLECULES IS 

5224
03:20:11,710 --> 03:20:14,880
REGISTERED AS PHENOMICS.

5225
03:20:14,880 --> 03:20:16,815
ON THE LAST CLICK ON THIS SLIDE 

5226
03:20:16,815 --> 03:20:18,918
IT SHOWS YOU THE MILLION PERSON 

5227
03:20:18,918 --> 03:20:20,753
PROJECT AND THE REASON IT IS SO 

5228
03:20:20,753 --> 03:20:24,323
IMPORTANT TO EXECUTE THAT IS IT 

5229
03:20:24,323 --> 03:20:27,760
WILL GIVE YOU THE ABILITY TO 

5230
03:20:27,760 --> 03:20:30,496
VALIDATE HEALTH IMPROVEMENT FOR 

5231
03:20:30,496 --> 03:20:32,464
INDIVIDUALS, COST SAVINGS, AND 

5232
03:20:32,464 --> 03:20:35,734
THE EMERGENCE OF NEW KINDS OF 

5233
03:20:35,734 --> 03:20:38,137
TECHNOLOGIES FOR PHENOMICS.

5234
03:20:38,137 --> 03:20:41,173
SO ON THE NEXT SLIDE YOU CAN SEE

5235
03:20:41,173 --> 03:20:43,642
THAT WE'VE USED THE APPROACHES 

5236
03:20:43,642 --> 03:20:46,879
OF SYSTEMS BIOLOGY TO CARRY OUT 

5237
03:20:46,879 --> 03:20:50,883
THESE DIFFERENT ANALYSES THAT IS

5238
03:20:50,883 --> 03:20:55,454
LOOKING IN A KWAN  -- 

5239
03:20:55,454 --> 03:20:57,656
QUANTITATIVE WAY AT SEQUENCE 

5240
03:20:57,656 --> 03:21:01,160
MOLECULES, DNA, RNA AND 

5241
03:21:01,160 --> 03:21:01,427
PROTEINS.

5242
03:21:01,427 --> 03:21:03,395
THE FIRST IDEA THAT EMERGED ON 

5243
03:21:03,395 --> 03:21:04,930
THE NEXT CLICK IS THE IDEA THAT 

5244
03:21:04,930 --> 03:21:08,434
BLOOD IS A SYSTEMS APPROACH AT 

5245
03:21:08,434 --> 03:21:11,003
LOOKING AT WELLNESS AND DISEASE.

5246
03:21:11,003 --> 03:21:13,172
THEY SECRETE MOLECULES INTO THE 

5247
03:21:13,172 --> 03:21:13,572
BLOOD.

5248
03:21:13,572 --> 03:21:15,174
IN SOME CASES WE CAN IDENTIFY 

5249
03:21:15,174 --> 03:21:17,810
THE ORIGIN OF THE MOLECULES AND 

5250
03:21:17,810 --> 03:21:20,713
BY FOLLOWING THEIR QUANTITATION,

5251
03:21:20,713 --> 03:21:25,384
WE CAN LOOK AT CHANGES 

5252
03:21:25,384 --> 03:21:31,824
INWELLNESS OPT MIZATION OF 

5253
03:21:31,824 --> 03:21:32,825
HEALTH AND DISEASE.

5254
03:21:32,825 --> 03:21:34,360
ON THE NEXT CLICK THIS WAS KIND 

5255
03:21:34,360 --> 03:21:37,129
OF A SYSTEMS APPROACH TO 

5256
03:21:37,129 --> 03:21:40,165
THINKING ABOUT BIOLOGY AND 

5257
03:21:40,165 --> 03:21:40,466
EVERYTHING.

5258
03:21:40,466 --> 03:21:47,806
AND SO NEXT CLICK, PLEASE.

5259
03:21:47,806 --> 03:21:52,144
AND OBVIOUSLY THE USE OF ALL OF 

5260
03:21:52,144 --> 03:22:02,688
THIS DIGITAL DATA THEN REQUIRED 

5261
03:22:08,494 --> 03:22:10,796
THAT ALLOWS US TO LOOK AT 

5262
03:22:10,796 --> 03:22:12,131
DYNAMIC COMMUNITIES.

5263
03:22:12,131 --> 03:22:14,400
ON THE LAST CLICK WE USE THE 

5264
03:22:14,400 --> 03:22:17,436
TOOLS OF AI WHICH INCLUDE 

5265
03:22:17,436 --> 03:22:19,104
KNOWLEDGE GRAPHS, DIGITAL TWINS 

5266
03:22:19,104 --> 03:22:21,306
AND ULTDLY LARGE LANGUAGE MODELS

5267
03:22:21,306 --> 03:22:22,808
OR TRANSFORMERS.

5268
03:22:22,808 --> 03:22:25,310
SO ON THE NEXT SLIDE, LET ME 

5269
03:22:25,310 --> 03:22:28,347
JUST REMIND YOU AGAIN THAT THE 

5270
03:22:28,347 --> 03:22:30,416
DATA FROM WHICH WE'LL DRAW SOME 

5271
03:22:30,416 --> 03:22:34,853
NOW GENERAL CONCLUSIONS, NEXT 

5272
03:22:34,853 --> 03:22:38,057
SLIDE, PLEASE, WAS A FOUR-YEAR 

5273
03:22:38,057 --> 03:22:44,196
PROGRAM AND WE DREW GENOME AND 

5274
03:22:44,196 --> 03:22:46,198
PHENOME DATE FROM 5,000 PEOPLE.

5275
03:22:46,198 --> 03:22:49,301
WE MEASURED SIX DIFFERENT DATA 

5276
03:22:49,301 --> 03:22:49,568
FEATURES.

5277
03:22:49,568 --> 03:22:56,442
ON THE NEXT CLIK YOU CAN CAN SEE

5278
03:22:56,442 --> 03:23:01,046
GENOME, NEXT CLICK, CHEMICAL 

5279
03:23:01,046 --> 03:23:07,553
PROTEINS AND METABOLITS AND GUT 

5280
03:23:07,553 --> 03:23:08,253
BIOME.

5281
03:23:08,253 --> 03:23:10,355
SO SIX DIFFERENT DATA FEATURES.

5282
03:23:10,355 --> 03:23:14,093
FROM ALL OF THESE STUDIES CAME 

5283
03:23:14,093 --> 03:23:16,195
CONCLUSIONS OF WHAT DATA-DRIVEN 

5284
03:23:16,195 --> 03:23:20,399
HEALTH WILL LEEZ US -- LEAD US 

5285
03:23:20,399 --> 03:23:22,067
TO ON THE NEXT SLIDE.

5286
03:23:22,067 --> 03:23:24,069
THE FIRST OF THESE -- NEXT 

5287
03:23:24,069 --> 03:23:25,437
SLIDE, PLEASE.

5288
03:23:25,437 --> 03:23:27,272
THE GENOME HAS AT LEAST EIGHT 

5289
03:23:27,272 --> 03:23:29,608
DIFFERENT CATEGORIES OF 

5290
03:23:29,608 --> 03:23:30,909
ACTIONABLE FEATURES THAT WE CAN 

5291
03:23:30,909 --> 03:23:38,884
LOOK AT ON THE NEXT CLICK, 

5292
03:23:38,884 --> 03:23:40,452
PLEASE.

5293
03:23:40,452 --> 03:23:42,988
MY GOODNESS, DOES EVERYBODY HAVE

5294
03:23:42,988 --> 03:23:46,091
THIS MUCH TROUBLE.

5295
03:23:46,091 --> 03:23:46,492
IT IS A DISASTER.

5296
03:23:46,492 --> 03:23:48,861
ANYWAY, THERE ARE FIVE 

5297
03:23:48,861 --> 03:23:49,728
OPPORTUNITIES, ONE IS EIGHT 

5298
03:23:49,728 --> 03:23:51,230
GENOME CATEGORY AND WE'LL TALK 

5299
03:23:51,230 --> 03:23:53,365
ABOUT THOSE IN A MOMENT.

5300
03:23:53,365 --> 03:23:57,269
THE SECOND HAS TO DO WITH 

5301
03:23:57,269 --> 03:23:58,003
STATISTICAL ANALYSES OF THE SIX 

5302
03:23:58,003 --> 03:24:00,572
DIFFERENT TYPES OF DATA.

5303
03:24:00,572 --> 03:24:02,441
AND ON THE NEXT CLICK WE'LL TALK

5304
03:24:02,441 --> 03:24:05,344
ABOUT THAT IN JUST A MOMENT, 

5305
03:24:05,344 --> 03:24:06,445
TOO.

5306
03:24:06,445 --> 03:24:07,813
CAN YOU CLICK THROUGH EACH OF 

5307
03:24:07,813 --> 03:24:09,281
THESE AND I WILL TALK ABOUT THEM

5308
03:24:09,281 --> 03:24:11,884
AND KEEP UP WITH YOU.

5309
03:24:11,884 --> 03:24:16,588
SO STATISTICAL ANALYSIS LEAD TO 

5310
03:24:16,588 --> 03:24:16,989
COMMUNITIES.

5311
03:24:16,989 --> 03:24:19,625
METRICS FOR WELLNESS, HEALTHY 

5312
03:24:19,625 --> 03:24:25,264
AGING AND PHYSIOLOGIC TRAITS 

5313
03:24:25,264 --> 03:24:28,333
LIKE BIOLOGICAL AGE AND BMI AND 

5314
03:24:28,333 --> 03:24:29,902
FRAILTY ARE IMPORTANT.

5315
03:24:29,902 --> 03:24:33,972
FINALLY, TRARNS  -- TRANSITION 

5316
03:24:33,972 --> 03:24:35,841
STATES FROM WELLNESS TO DISEASE 

5317
03:24:35,841 --> 03:24:38,477
AND WE CAN DETECT THOSE IN THREE

5318
03:24:38,477 --> 03:24:39,244
WAYS.

5319
03:24:39,244 --> 03:24:40,846
ONE IS USING BLOOD ORGAN 

5320
03:24:40,846 --> 03:24:42,915
SPECIFIC PROTEINS THAT ASSESS 

5321
03:24:42,915 --> 03:24:44,783
THE STATE OF WELLNESS AND 

5322
03:24:44,783 --> 03:24:46,018
DISEASE FOR 25 DIFFERENT ORGANS 

5323
03:24:46,018 --> 03:24:51,757
SIMULTANEOUSLY.

5324
03:24:51,757 --> 03:24:53,458
AND FINALLY, WE ARE GOING TO 

5325
03:24:53,458 --> 03:24:56,361
SHOW YOU WELLNESS IS THE TOTAL 

5326
03:24:56,361 --> 03:24:59,031
DIMENSIONAL TILL OF HEALTHY 

5327
03:24:59,031 --> 03:25:00,799
AGING AND CONTRAST WITH GENERAL 

5328
03:25:00,799 --> 03:25:02,267
SCIENCE AND WHAT THAT BRINGS TO 

5329
03:25:02,267 --> 03:25:02,467
US.

5330
03:25:02,467 --> 03:25:04,670
THE FINAL POINT IS THERE ARE 

5331
03:25:04,670 --> 03:25:06,471
THREE ASPECTS OF HEALTH WE NEED 

5332
03:25:06,471 --> 03:25:08,273
TO BE ABLE TO INTEGRATE AND 

5333
03:25:08,273 --> 03:25:08,540
OPTIMIZE.

5334
03:25:08,540 --> 03:25:10,342
HEALTH OF THE BRAIN, HEALTH OF 

5335
03:25:10,342 --> 03:25:16,215
THE BODY, HEALTH OF THE GUT 

5336
03:25:16,215 --> 03:25:16,515
MICROBIOME.

5337
03:25:16,515 --> 03:25:18,717
THEY ALL INTERPLAY IN ENORMOUSLY

5338
03:25:18,717 --> 03:25:19,718
POWERFUL DIFFERENT WAYS.

5339
03:25:19,718 --> 03:25:22,254
ON THE NEXT SLIDE YOU CAN SEE A 

5340
03:25:22,254 --> 03:25:24,790
LIST OF THE EIGHT DIFFERENT 

5341
03:25:24,790 --> 03:25:25,624
GENOME POSSIBILITIES AND I THINK

5342
03:25:25,624 --> 03:25:29,027
THE TWO THAT ARE REALLY MOST 

5343
03:25:29,027 --> 03:25:35,567
RELEVANT TO YOU ARE THE 

5344
03:25:35,567 --> 03:25:42,307
POLYGENIC VARIANTS AND I 

5345
03:25:42,307 --> 03:25:46,612
POLYGENI PHENOTYPES.

5346
03:25:46,612 --> 03:25:48,280
THE POINT ON THE NEXT CLICK IS 

5347
03:25:48,280 --> 03:25:51,216
IT GIVES US FOUR DIFFERENT 

5348
03:25:51,216 --> 03:25:53,719
POSSIBILITIES FOR OPTIMIZING 

5349
03:25:53,719 --> 03:25:55,020
HEALTH.

5350
03:25:55,020 --> 03:25:56,088
NEXT CLICK, PLEASE.

5351
03:25:56,088 --> 03:25:58,891
SO ONE IS THE ABILITY TO 

5352
03:25:58,891 --> 03:26:01,593
OPTIMIZE WELLNESS AND AGING.

5353
03:26:01,593 --> 03:26:09,134
ANOTHER IS THE ABILITY TO 

5354
03:26:09,134 --> 03:26:13,772
AMELIORATE OR REVERSE GENOME OR 

5355
03:26:13,772 --> 03:26:23,515
PHENOME, YOUR BEHAVIOR, LEAD 

5356
03:26:23,515 --> 03:26:25,851
TO -- THE THIRD IS THE IDEA WE 

5357
03:26:25,851 --> 03:26:27,753
CAN DO EARLY DISEASE DETECTION 

5358
03:26:27,753 --> 03:26:29,354
AND PREVENTION AND THE FOURTH IS

5359
03:26:29,354 --> 03:26:31,223
WE CAN DEAL WITH DIAGNOSED 

5360
03:26:31,223 --> 03:26:33,258
DISEASE VERY EFFECTIVE WITH THE 

5361
03:26:33,258 --> 03:26:34,893
SYSTEMS APPROACH AS IN WHAT 

5362
03:26:34,893 --> 03:26:36,828
PEOPLE ARE CALLING PRECISION 

5363
03:26:36,828 --> 03:26:37,529
MEDICINE NOW.

5364
03:26:37,529 --> 03:26:48,040
SO ON THE NEXT SLIDE, WE CAN 

5365
03:26:48,240 --> 03:26:49,841
LOOK AT THE STATISTICS.

5366
03:26:49,841 --> 03:26:53,812
THIS IS A COMPLICATED SLIDE WITH

5367
03:26:53,812 --> 03:26:54,212
MANY CLICKS.

5368
03:26:54,212 --> 03:26:55,347
IF WE COULD GET STARTED.

5369
03:26:55,347 --> 03:26:58,250
WE ARE LOOKING AT STATISTICAL 

5370
03:26:58,250 --> 03:27:00,018
POSSIBILITIES WHERE WE FIRST 

5371
03:27:00,018 --> 03:27:01,687
STUDIED THE 108 PEOPLE AND WERE 

5372
03:27:01,687 --> 03:27:03,088
ABLE TO DEMONSTRATE THE SIX 

5373
03:27:03,088 --> 03:27:07,693
DIFFERENT DATA TYPES.

5374
03:27:07,693 --> 03:27:08,827
THERE WERE ABOUT 3500 

5375
03:27:08,827 --> 03:27:11,396
STATISTICAL CORRELATIONS.

5376
03:27:14,333 --> 03:27:16,335
AN EXAMPLE FOR ME WAS WHERE I 

5377
03:27:16,335 --> 03:27:18,704
HAD VERY LOW VITAMIN D AND IT 

5378
03:27:18,704 --> 03:27:20,839
TURNED OUT I HAD TWO VARIANT 

5379
03:27:20,839 --> 03:27:23,575
GENES THAT BLOCKED THE UPDATE IN

5380
03:27:23,575 --> 03:27:25,410
VITAMIN D AND TO BRING MYSELF UP

5381
03:27:25,410 --> 03:27:29,915
TO A NORMAL LEVEL I HAD TO USE 

5382
03:27:29,915 --> 03:27:31,116
EXTREME DOSES, 15,000 

5383
03:27:31,116 --> 03:27:32,918
INTERNATIONAL UNITS AND MAINTAIN

5384
03:27:32,918 --> 03:27:34,186
AT 5,000 UNITS.

5385
03:27:34,186 --> 03:27:39,791
THAT WAS AN EXAMPLE OF FIXING A 

5386
03:27:39,791 --> 03:27:42,627
DEFICIENCY IN THE GENOME THAT 

5387
03:27:42,627 --> 03:27:43,295
OPTIMIZED HEALTH.

5388
03:27:43,295 --> 03:27:46,732
IT LED TO VARIOUS BIOLOGICAL 

5389
03:27:46,732 --> 03:27:47,766
NETWORKS AND DETAIL 

5390
03:27:47,766 --> 03:27:49,935
UNDERSTANDING OF WHY THE FAILURE

5391
03:27:49,935 --> 03:27:50,569
OCCURRED.

5392
03:27:50,569 --> 03:27:53,705
SO THAT IS CLASSIC BIOLOGICAL 

5393
03:27:53,705 --> 03:27:57,242
NETWORKS AND THEY ARE ALL ONE 

5394
03:27:57,242 --> 03:27:59,077
DIMENSIONAL.

5395
03:27:59,077 --> 03:28:00,946
PROTEINS, TRANSCRIPTION FACTORS.

5396
03:28:00,946 --> 03:28:02,481
A SECOND STATISTICAL APPROACH IN

5397
03:28:02,481 --> 03:28:03,682
THE NEXT CLICK IS CALLED 

5398
03:28:03,682 --> 03:28:05,784
COMMUNITY ANALYSIS.

5399
03:28:05,784 --> 03:28:07,686
AND WHAT IT DOES ON THE NEXT 

5400
03:28:07,686 --> 03:28:11,189
CLICK, GO AHEAD, IS IT TAKES 

5401
03:28:11,189 --> 03:28:14,760
THIS HAIR BALL AND IT BASICALLY 

5402
03:28:14,760 --> 03:28:18,063
ASKS GIVE US THE FEATURES OF 

5403
03:28:18,063 --> 03:28:19,731
DATA THAT ARE MOST CLOSELY 

5404
03:28:19,731 --> 03:28:21,967
RELATED STATISTICALLY TO ONE 

5405
03:28:21,967 --> 03:28:24,369
ANOTHER AND IT TURNED OUT WITH 

5406
03:28:24,369 --> 03:28:27,105
108 PEOPLE WE HAD 70 COMMUNITIES

5407
03:28:27,105 --> 03:28:29,908
OF FEATURES YOU CAN SEE HERE AND

5408
03:28:29,908 --> 03:28:32,711
WHAT WAS REMARKABLE ON THE NEXT 

5409
03:28:32,711 --> 03:28:35,914
CLICK IS ALMOST ALL OF THOSE 

5410
03:28:35,914 --> 03:28:39,284
COMMUNITIES MAPPED INTO NORMAL 

5411
03:28:39,284 --> 03:28:41,453
PHYSIOLOGY OR DISEASE 

5412
03:28:41,453 --> 03:28:41,753
PHYSIOLOGY.

5413
03:28:41,753 --> 03:28:44,256
AND THE IMPORTANT POINT WAS THEY

5414
03:28:44,256 --> 03:28:46,625
RELATED ALL SIX OF THE DIFFERENT

5415
03:28:46,625 --> 03:28:48,126
DIMENSIONS OF DATA TOGETHER IN A

5416
03:28:48,126 --> 03:28:51,630
VERY DIFFERENT WAY FROM THE 

5417
03:28:51,630 --> 03:28:53,899
FIRST BIOLOGICAL NETWORKS WE 

5418
03:28:53,899 --> 03:28:56,001
TALKED ABOUT.

5419
03:28:56,001 --> 03:28:57,102
AND, IN FACT, ON THE NEXT CLICK,

5420
03:28:57,102 --> 03:29:00,372
TWO CLICKS, ACTUALLY, YOU CAN 

5421
03:29:00,372 --> 03:29:03,341
SEE ONE OF THESE NETWORKS 

5422
03:29:03,341 --> 03:29:09,781
EXPLODING OUT, I HOPE, CLICK 

5423
03:29:09,781 --> 03:29:09,981
AGAIN.

5424
03:29:09,981 --> 03:29:11,883
>> IT EXPLODED.

5425
03:29:11,883 --> 03:29:15,787
>> OH, WELL, ANYWAY, ONE 

5426
03:29:15,787 --> 03:29:19,825
EXPLODES OUT TO SHOW THAT YOU 

5427
03:29:19,825 --> 03:29:23,895
HAVE 12ANALITES THAT COORDINATE 

5428
03:29:23,895 --> 03:29:28,733
WITH LDL CHOLESTEROL, ONE WAS 

5429
03:29:28,733 --> 03:29:31,002
THYROXIN, IT TURNED OUT LILY HAD

5430
03:29:31,002 --> 03:29:33,705
IT IN THE FINAL STAGES OF CLASS 

5431
03:29:33,705 --> 03:29:35,173
3 FOR AEBT CHOLESTEROL.

5432
03:29:35,173 --> 03:29:38,577
ALL I'M SAYING IS THESE 

5433
03:29:38,577 --> 03:29:40,479
COMMUNITIES GIVE US ENORMOUS 

5434
03:29:40,479 --> 03:29:42,447
POSSIBILITIES TO CREATE 

5435
03:29:42,447 --> 03:29:44,449
BIOMARKER AND DRUG TARGETS FOR 

5436
03:29:44,449 --> 03:29:45,117
THE FUTURE.

5437
03:29:45,117 --> 03:29:46,918
IN FACT, ON THE NEXT CLICK, IN 

5438
03:29:46,918 --> 03:29:49,121
THE ORIGINAL 100 PEOPLE WE 

5439
03:29:49,121 --> 03:29:51,756
LOOKED AT 500 PROTEINS.

5440
03:29:51,756 --> 03:29:54,893
ON THE NEXT CLICK WE LOOKED AT 

5441
03:29:54,893 --> 03:29:58,897
5,000 PROTEINS AND WE HAD 10 

5442
03:29:58,897 --> 03:30:01,066
TIMES AS MANY STATISTICAL 

5443
03:30:01,066 --> 03:30:01,766
ASSOCIATIONS.

5444
03:30:01,766 --> 03:30:03,368
AND HUNDREDS OF COMMUNITIES THAT

5445
03:30:03,368 --> 03:30:06,238
WERE INTERACTING AND WHEN WE 

5446
03:30:06,238 --> 03:30:09,307
MOVED FROM 100 TO 5,000, WE EVEN

5447
03:30:09,307 --> 03:30:10,342
HAD MORE.

5448
03:30:10,342 --> 03:30:13,411
SO WE HAVE ENORMOUS NUMBERS OF 

5449
03:30:13,411 --> 03:30:14,146
DRUG TARGETS.

5450
03:30:14,146 --> 03:30:17,916
AND THIS IS AN EXAMPLE OF ONE OF

5451
03:30:17,916 --> 03:30:20,685
THE METRICS WE HAVE FOR 

5452
03:30:20,685 --> 03:30:22,287
PHYSIOLOGIC CHANGE CALLED 

5453
03:30:22,287 --> 03:30:25,824
BIOLOGICAL AGE WHERE IT MEASURES

5454
03:30:25,824 --> 03:30:27,692
THE AGE YOUR BODY SAYS YOU ARE 

5455
03:30:27,692 --> 03:30:30,762
AS OPPOSED TO YOUR CHRONOLOGICAL

5456
03:30:30,762 --> 03:30:31,396
AGE.

5457
03:30:31,396 --> 03:30:35,267
THE LOWER YOUR BIOLOGICAL AGE 

5458
03:30:35,267 --> 03:30:41,973
RELATIVE TO YOUR CHRONOLOGICAL 

5459
03:30:41,973 --> 03:30:42,574
AGE, THE BETTER YOU ARE AGING.

5460
03:30:42,574 --> 03:30:43,308
LET'S GO THROUGH FIVE CLICKS.

5461
03:30:43,308 --> 03:30:46,711
WE WERE ABLE TO SHOW FOR EVERY 

5462
03:30:46,711 --> 03:30:49,014
YEAR A WOMAN STAYED IN THE 

5463
03:30:49,014 --> 03:30:52,417
WELLNESS PROGRAM, SHE LOST 1.5 

5464
03:30:52,417 --> 03:30:54,886
YEARS OF BIOLOGICAL AGE, MEN 

5465
03:30:54,886 --> 03:30:56,254
LOST .8.

5466
03:30:56,254 --> 03:30:58,890
A SECOND THING WAS THE METRICS 

5467
03:30:58,890 --> 03:31:02,928
COULD BE SPECIFIC FOR ORGANS, 

5468
03:31:02,928 --> 03:31:05,130
MAJOR ORGANS AND YOU GET THE 

5469
03:31:05,130 --> 03:31:06,331
BIOLOGICAL AGE OF THE ORGANS.

5470
03:31:06,331 --> 03:31:10,502
A THIRD IDEA WAS THE METRIC 

5471
03:31:10,502 --> 03:31:11,102
COMPONENTS THEMSELVES GAVE US 

5472
03:31:11,102 --> 03:31:14,206
ADVICE ON HOW TO OPTIMIZE ONE'S 

5473
03:31:14,206 --> 03:31:16,441
BIOLOGICAL AGE, THAT IS REDUCE 

5474
03:31:16,441 --> 03:31:16,875
IT.

5475
03:31:16,875 --> 03:31:18,610
AND THEN FINALLY IN EVERY CASE 

5476
03:31:18,610 --> 03:31:20,845
WE LOOKED AT, MORE THAN 40 

5477
03:31:20,845 --> 03:31:23,114
DIFFERENT MINOR AND MAJOR 

5478
03:31:23,114 --> 03:31:25,050
DISEASES THAT BIOLOGICAL AGE 

5479
03:31:25,050 --> 03:31:26,885
INCREASED SIGNIFICANTLY.

5480
03:31:26,885 --> 03:31:37,395
AND WE WERE ABLE THEN TO TAKE 

5481
03:31:38,196 --> 03:31:38,763
THE COMPONENTS OF THE BIOLOGICAL

5482
03:31:38,763 --> 03:31:40,999
AGE, MAP THEM INTO GRAPHS AND 

5483
03:31:40,999 --> 03:31:43,201
GAIN ENORMOUS INSIGHTS INTO THE 

5484
03:31:43,201 --> 03:31:45,437
FEATURE THAT THE METRIC ACTUALLY

5485
03:31:45,437 --> 03:31:45,737
REPRESENTED.

5486
03:31:45,737 --> 03:31:48,373
IT GAVE US INSIGHTS INTO 

5487
03:31:48,373 --> 03:31:50,709
BIOLOGICAL NETWORKS AND 

5488
03:31:50,709 --> 03:31:51,543
BIOLOGICAL COMMUNITIES.

5489
03:31:51,543 --> 03:31:53,612
AND THEN ON THE LAST, IS THERE 

5490
03:31:53,612 --> 03:31:54,613
ONE MORE CLICK?

5491
03:31:54,613 --> 03:32:05,023
LET'S GO ONE MORE CLICK.

5492
03:32:07,892 --> 03:32:08,426
WE COULD DO THE SAME FOR THE 

5493
03:32:08,426 --> 03:32:08,994
BIOLOGICAL BMI AND FRAILTY 

5494
03:32:08,994 --> 03:32:09,294
INDEX, TOO.

5495
03:32:09,294 --> 03:32:10,895
THIS SHOWS THE POWER OF A FOUR 

5496
03:32:10,895 --> 03:32:12,731
YEAR GLIMPSE ACROSS A SET OF 

5497
03:32:12,731 --> 03:32:18,270
PEOPLE FROM 21 YEARS TO 93 YEARS

5498
03:32:18,270 --> 03:32:22,907
IN AGE AND HOW THEY GAVE US AN 

5499
03:32:22,907 --> 03:32:23,975
ENORMOUSLY BROAD REPRESENTATION 

5500
03:32:23,975 --> 03:32:25,477
OF INDIVIDUALS AT ALL DIFFERENT 

5501
03:32:25,477 --> 03:32:27,045
STAGES OF THEIR LIFE.

5502
03:32:27,045 --> 03:32:29,447
ON THE NEXT SLIDE IS THE REALLY 

5503
03:32:29,447 --> 03:32:32,317
IMPORTANT POINT THAT WE CAN 

5504
03:32:32,317 --> 03:32:35,053
ACTUALLY INTERROGATE AT A VERY 

5505
03:32:35,053 --> 03:32:37,088
EARLY STAGE, TRANSITIONS FROM 

5506
03:32:37,088 --> 03:32:41,593
WELLNESS TO DISEASE, WHERE IN 

5507
03:32:41,593 --> 03:32:43,295
CONVENTION MEDICINE, DO A SERIES

5508
03:32:43,295 --> 03:32:45,497
OF CLICKS, ABOUT THREE CLICKS 

5509
03:32:45,497 --> 03:32:45,864
ACROSS.

5510
03:32:45,864 --> 03:32:49,634
WHAT YOU SEE ARE INCREASINGLY 

5511
03:32:49,634 --> 03:32:52,504
DISARRAY DISEASE PERTURBED 

5512
03:32:52,504 --> 03:32:54,439
BIOLOGICAL NETWORKS AS THE 

5513
03:32:54,439 --> 03:32:55,974
DISEASE PROGRESSES UP TO THE 

5514
03:32:55,974 --> 03:32:57,909
NEXT CLICK, A CLINICAL 

5515
03:32:57,909 --> 03:32:58,209
DIAGNOSIS.

5516
03:32:58,209 --> 03:33:00,145
WHEN ALMOST ALL CHRONIC DISEASES

5517
03:33:00,145 --> 03:33:03,348
ARE QUITE COMPLICATED AND MOST 

5518
03:33:03,348 --> 03:33:04,816
DRUGS ARE HITTING A SYMPTOM, 

5519
03:33:04,816 --> 03:33:06,351
THEY ARE NOT HITTING THE 

5520
03:33:06,351 --> 03:33:09,788
FUNDAMENTAL CAUSE OF THE 

5521
03:33:09,788 --> 03:33:10,055
DISEASE.

5522
03:33:10,055 --> 03:33:13,224
AND ON THE NEXT CLICK, WHAT WE 

5523
03:33:13,224 --> 03:33:15,860
WERE ABLE TO SEE OOVER FOUR 

5524
03:33:15,860 --> 03:33:18,630
YEARS IS 167 WELLNESS TO DISEASE

5525
03:33:18,630 --> 03:33:18,930
TRANSITIONS.

5526
03:33:18,930 --> 03:33:21,866
30 OF WHICH WENT TO DIFFERENT 

5527
03:33:21,866 --> 03:33:22,100
CANCERS.

5528
03:33:22,100 --> 03:33:26,504
AND WE ANALYZED BLOODS PRIOR TO 

5529
03:33:26,504 --> 03:33:29,174
THE DIAGNOSIS TIME FOR 10 OF 

5530
03:33:29,174 --> 03:33:31,710
THOSE CANCERS AND WERE ABLE TO 

5531
03:33:31,710 --> 03:33:33,645
DEMONSTRATE IN EVERY CASE 

5532
03:33:33,645 --> 03:33:35,046
MULTIPLE ELEVATED PROTEINS, 

5533
03:33:35,046 --> 03:33:37,849
WHICH FOR THE DIFFERENT TYPES OF

5534
03:33:37,849 --> 03:33:40,218
CANCER, MAPPED INTO RELEVANT 

5535
03:33:40,218 --> 03:33:42,320
DISEASE PERTURBED NETWORKS FOR 

5536
03:33:42,320 --> 03:33:43,321
THOSE CANCERS.

5537
03:33:43,321 --> 03:33:46,358
AND WE MEASURED THEM ONE TO FOUR

5538
03:33:46,358 --> 03:33:48,126
YEARS PRIOR TO CLINICAL 

5539
03:33:48,126 --> 03:33:48,893
DIAGNOSIS.

5540
03:33:48,893 --> 03:33:50,995
SO THEY GIVE US THE CLUE AS TO 

5541
03:33:50,995 --> 03:33:53,865
WHERE TO GO TO START ON THE NEXT

5542
03:33:53,865 --> 03:33:57,936
CLICK WHAT WE CALL PHENOMIC 

5543
03:33:57,936 --> 03:34:00,739
MEDICINE WHERE WE CAN DO -- WE 

5544
03:34:00,739 --> 03:34:07,312
CAN FIND THE EARLIEST DISEASE 

5545
03:34:07,312 --> 03:34:08,913
PERTUBATION, CLICK, PLEASE, NEXT

5546
03:34:08,913 --> 03:34:10,949
SLIDE AND NEXT SLIDE.

5547
03:34:10,949 --> 03:34:15,587
WE CAN GET THE DISEASE PERTURBED

5548
03:34:15,587 --> 03:34:17,989
NETWORKS, NEXT SLIDE PLEASE AND 

5549
03:34:17,989 --> 03:34:19,691
TAKE A PREVENTIVE DRUG AND BRING

5550
03:34:19,691 --> 03:34:22,594
THEM BACK TO NORMAL BEFORE THEY 

5551
03:34:22,594 --> 03:34:23,595
EVER REVERT TO DISEASE.

5552
03:34:23,595 --> 03:34:26,364
THIS IS THE WELLNESS TO DISEASE 

5553
03:34:26,364 --> 03:34:29,000
AND THE IDEA HERE IS IN OVER A 

5554
03:34:29,000 --> 03:34:31,336
10-YEAR PERIOD WE COULD HAVE A 

5555
03:34:31,336 --> 03:34:33,872
MAJOR IMPACT ON AVOIDING CHRONIC

5556
03:34:33,872 --> 03:34:34,472
DISEASES.

5557
03:34:34,472 --> 03:34:38,877
AND ON THE NEXT SLIDE IS JUST A 

5558
03:34:38,877 --> 03:34:45,450
SIMPLE REPRESENTATION OF ANOTHER

5559
03:34:45,450 --> 03:34:49,954
APPROACH TO EARLY DISEASE 

5560
03:34:49,954 --> 03:34:50,789
TRANSITIONS IS THE ORGAN 

5561
03:34:50,789 --> 03:34:51,723
SPECIFIC PROTEINS.

5562
03:34:51,723 --> 03:34:53,291
ON THE NEXT SLIDE YOU CAN SHOW 

5563
03:34:53,291 --> 03:34:55,794
FOR THE BRAIN, WE HAD MORE THAN 

5564
03:34:55,794 --> 03:34:59,764
600 OR 700 ORGAN SPECIFIC 

5565
03:34:59,764 --> 03:35:00,999
TRANSCRIPTS WHICH IN A NORMAL 

5566
03:35:00,999 --> 03:35:03,101
INDIVIDUAL RELATED TO ONLY 10 OR

5567
03:35:03,101 --> 03:35:05,403
SO PROTEINS WE COULD DETECT IN 

5568
03:35:05,403 --> 03:35:06,771
THE BLOOD.

5569
03:35:06,771 --> 03:35:13,211
BUT IN A DISEASED INDIVIDUAL, 

5570
03:35:13,211 --> 03:35:17,382
THE BLOOD/BRAIN BARRIER OPENED 

5571
03:35:17,382 --> 03:35:19,083
UP AND THE BLOOD MAPPED 

5572
03:35:19,083 --> 03:35:21,286
BEAUTIFULLY AND FOR THE BRAIN IT

5573
03:35:21,286 --> 03:35:22,887
MAPPED INTO REGIONS OF THE BRAIN

5574
03:35:22,887 --> 03:35:26,524
SO YOU CAN SEE WHERE THE 

5575
03:35:26,524 --> 03:35:27,425
BLOOD/BRAIN BARRIER HAD BEEN 

5576
03:35:27,425 --> 03:35:27,659
DISEASE.

5577
03:35:27,659 --> 03:35:30,028
ON THE NEXT SLIDE, WE DID 

5578
03:35:30,028 --> 03:35:32,430
EXACTLY THE SAME FOR THE 

5579
03:35:32,430 --> 03:35:35,733
PLACENTA IN STUDIES I WILL TALK 

5580
03:35:35,733 --> 03:35:37,802
ABOUT LATER ON PREGNANCY.

5581
03:35:37,802 --> 03:35:43,475
WE HAD 31 ORGAN SPECIFIC 

5582
03:35:43,475 --> 03:35:46,010
PROTEINS AND GAVE US INSIGHTS 

5583
03:35:46,010 --> 03:35:48,213
INTO MATERNAL HEALTH AND FETAL 

5584
03:35:48,213 --> 03:35:48,413
HELTS.

5585
03:35:48,413 --> 03:35:50,048
ON THE NEXT SLIDE IN THIS 

5586
03:35:50,048 --> 03:35:52,217
SERIES, WE LOOKED IN A BROAD 

5587
03:35:52,217 --> 03:35:55,520
SENSE AT SCIENTIFIC WELLNESS AND

5588
03:35:55,520 --> 03:35:58,423
ALL OF THE METRICS THAT IT 

5589
03:35:58,423 --> 03:35:58,656
ENTAILS.

5590
03:35:58,656 --> 03:36:00,959
IF WE COULD HAVE THE NEXT SLIDE,

5591
03:36:00,959 --> 03:36:01,659
PLEASE.

5592
03:36:01,659 --> 03:36:05,129
AND THESE ARE ALL THE OMICS AND 

5593
03:36:05,129 --> 03:36:06,631
CLINICAL DATA AND ALL OF THE 

5594
03:36:06,631 --> 03:36:08,433
THINGS WE ARE SO FAMILIAR WITH.

5595
03:36:08,433 --> 03:36:12,637
AND WHAT A SYSTEMS APPROACH TO 

5596
03:36:12,637 --> 03:36:14,873
DISEASE IS ABOUT IS DISCOVERY 

5597
03:36:14,873 --> 03:36:17,675
DRIVEN, IT IS NOT HYPOTHESIS 

5598
03:36:17,675 --> 03:36:17,909
DRIVEN.

5599
03:36:17,909 --> 03:36:19,244
YOU LOOK AT EVERYTHING THAT IS 

5600
03:36:19,244 --> 03:36:21,613
THERE AND YOU DEDUCE HOW THE 

5601
03:36:21,613 --> 03:36:22,547
CHANGE HAS COME ABOUT.

5602
03:36:22,547 --> 03:36:26,050
ON THE NEXT CLICK IS IN STRIKING

5603
03:36:26,050 --> 03:36:28,453
CONTRAST TO GERO SCIENCE WHERE 

5604
03:36:28,453 --> 03:36:31,122
THE FOCUS IS ON THE 12 HALL 

5605
03:36:31,122 --> 03:36:34,592
MAREKS FOR NOW 14 HALLMARKS OF 

5606
03:36:34,592 --> 03:36:37,395
AGING.

5607
03:36:37,395 --> 03:36:42,734
AND IT'S FOCUSED AND HYPOTHESIS 

5608
03:36:42,734 --> 03:36:42,967
DRIVEN.

5609
03:36:42,967 --> 03:36:46,404
I SET UP AN INTEGRATION WITH THE

5610
03:36:46,404 --> 03:36:48,172
BUCK TO INTEGRATE THESE TWO 

5611
03:36:48,172 --> 03:36:50,909
THINGS WITH THE NETWORKS AND 

5612
03:36:50,909 --> 03:36:51,910
DYNAMIC BIOLOGICAL COMMUNITIES 

5613
03:36:51,910 --> 03:36:54,779
WE TALKED ABOUT.

5614
03:36:54,779 --> 03:36:56,581
THEY LEAD TO A FASCINATING 

5615
03:36:56,581 --> 03:36:57,882
BEGINNING INTEGRATION ON THE 

5616
03:36:57,882 --> 03:37:02,253
NEXT CLICK THAT I'M CONVINCED IS

5617
03:37:02,253 --> 03:37:03,254
GOING TO COME TO THE ABILITY 

5618
03:37:03,254 --> 03:37:05,523
TO -- FOR MANY PEOPLE, ANYWAY, 

5619
03:37:05,523 --> 03:37:09,394
TO HAVE -- COULD WE CLICK NEXT.

5620
03:37:09,394 --> 03:37:11,563
A HEALTH SPAN THAT MOVES INTO 90

5621
03:37:11,563 --> 03:37:14,899
YEARS AND BEYOND.

5622
03:37:14,899 --> 03:37:18,603
SO LET'S GO FROM WHERE WE STAND 

5623
03:37:18,603 --> 03:37:22,907
NOW AND WHERE WE ARE GOING TO IN

5624
03:37:22,907 --> 03:37:28,046
THE FUTURE.

5625
03:37:28,046 --> 03:37:38,156
OKAY.

5626
03:37:45,797 --> 03:37:50,902
IT IS FEATURES BY ANTHROPORMIC 

5627
03:37:50,902 --> 03:37:51,336
DATA.

5628
03:37:51,336 --> 03:37:53,404
IF YOU DO THIS DATA DRIVEN AND 

5629
03:37:53,404 --> 03:37:54,973
LET'S GO THROUGH A SERIES OF 

5630
03:37:54,973 --> 03:37:56,674
CLICKS EACH WITH THE DIFFERENT 

5631
03:37:56,674 --> 03:37:58,710
DIMENSIONS OF SYSTEMS DRIVEN 

5632
03:37:58,710 --> 03:38:01,746
SCIENCE EXTENDS ENORMOUSLY THE 

5633
03:38:01,746 --> 03:38:05,149
ACTIONABLE POSSIBILITIES TO 

5634
03:38:05,149 --> 03:38:06,384
OPTIMIZE WELLNESS.

5635
03:38:06,384 --> 03:38:07,852
OR AVOID DISEASE.

5636
03:38:07,852 --> 03:38:10,888
THE GENOME DOES IT.

5637
03:38:10,888 --> 03:38:13,958
THE MICROBIOME DOES IT.

5638
03:38:13,958 --> 03:38:17,695
CLICK THROUGH THESE NEXT CLICKS.

5639
03:38:17,695 --> 03:38:21,232
AND THE WEARABLES DO IT AS WELL 

5640
03:38:21,232 --> 03:38:31,542
ON THE NEXT CLICK.

5641
03:38:43,421 --> 03:38:46,924
 THIS GIVES US THE ABILITY TO 

5642
03:38:46,924 --> 03:38:48,993
ANALYZE UNIQUENESS OF THESE 

5643
03:38:48,993 --> 03:38:50,895
INDIVIDUALS AND TO DO THE THINGS

5644
03:38:50,895 --> 03:38:53,464
I TALKED ABOUT, OPTIMIZE 

5645
03:38:53,464 --> 03:38:56,234
WELLNESS, LOOK AT DISEASE 

5646
03:38:56,234 --> 03:38:58,469
DETECTION, AND ON THE NEXT CLICK

5647
03:38:58,469 --> 03:39:01,239
ABLE TO DEAL WITH DISEASE AND 

5648
03:39:01,239 --> 03:39:04,842
ACTUALLY TO LEAD TO BIOMARKER 

5649
03:39:04,842 --> 03:39:07,945
DRUG TARGET DISCOVERY AND NEXT 

5650
03:39:07,945 --> 03:39:09,313
CLICK, PLEASE.

5651
03:39:09,313 --> 03:39:11,516
AND EVEN CAUSAL RELATIONSHIPS 

5652
03:39:11,516 --> 03:39:12,050
AND SO FORTH.

5653
03:39:12,050 --> 03:39:14,652
SO NOW LET'S GO ON AND TALK 

5654
03:39:14,652 --> 03:39:15,319
ABOUT WHERE WE'RE GOING TO IN 

5655
03:39:15,319 --> 03:39:21,359
THE FUTURE.

5656
03:39:21,359 --> 03:39:23,127
NEXT CLICK.

5657
03:39:23,127 --> 03:39:26,864
SO I JUST POSED THE QUESTION 

5658
03:39:26,864 --> 03:39:32,870
WHERE WE'RE GOING IN THE FUTURE?

5659
03:39:32,870 --> 03:39:36,140
IT COMES FROM PUBLICATIONS AND 

5660
03:39:36,140 --> 03:39:37,942
SCIENTIFIC JOURNALS THAT HAVE 

5661
03:39:37,942 --> 03:39:39,711
GWYNN US A GLIMPSE OF WHAT IT 

5662
03:39:39,711 --> 03:39:42,780
MEANS IN THE POPULATION OF 5,000

5663
03:39:42,780 --> 03:39:44,482
INDIVIDUALS OVER A FOUR-YEAR 

5664
03:39:44,482 --> 03:39:44,716
PERIOD.

5665
03:39:44,716 --> 03:39:46,751
ON THE NEXT CLICK, IT PLACES US 

5666
03:39:46,751 --> 03:39:50,154
NOW IN A POSITION TO SAY, WHERE 

5667
03:39:50,154 --> 03:39:51,289
ARE WE GOING TO GO?

5668
03:39:51,289 --> 03:39:53,458
AND ON THE NEXT CLICK I'LL START

5669
03:39:53,458 --> 03:39:55,159
TO TELL YOU WHERE WE'RE GOING TO

5670
03:39:55,159 --> 03:39:55,626
GO.

5671
03:39:55,626 --> 03:39:58,429
AND THE FIRST THING, OF COURSE, 

5672
03:39:58,429 --> 03:40:03,201
IS THE MISSION OF PHENOME 

5673
03:40:03,201 --> 03:40:04,569
HEALTH, FOUR FOLD.

5674
03:40:04,569 --> 03:40:08,106
ONE TO GENERATE AND AGGREGATE 

5675
03:40:08,106 --> 03:40:13,377
VERY LARGE SCALE GENOMIC, 

5676
03:40:13,377 --> 03:40:15,480
PHENOMIC INFORMATION AND CREATE 

5677
03:40:15,480 --> 03:40:17,682
FEDERATED DATA BASES IN WHICH WE

5678
03:40:17,682 --> 03:40:21,119
BRING OUR ANALYTIC TOOLS TO ON A

5679
03:40:21,119 --> 03:40:22,120
NATIONAL AND INTERNATIONAL 

5680
03:40:22,120 --> 03:40:23,221
BASIS, AS YOU WILL SEE.

5681
03:40:23,221 --> 03:40:25,423
NUMBER TWO, WE CAN ANALYZE THE 

5682
03:40:25,423 --> 03:40:35,867
GENOME AND PHENOME AND WE 

5683
03:40:36,434 --> 03:40:40,271
CREATED A DATA BASE AND WILL BE 

5684
03:40:40,271 --> 03:40:42,673
LOOKING NOT ONLY AT INDIVIDUAL 

5685
03:40:42,673 --> 03:40:44,942
PHENOMES, BUT CHRONIC MAJOR 

5686
03:40:44,942 --> 03:40:46,177
DISEASES, THE TOP FOUR AND I'LL 

5687
03:40:46,177 --> 03:40:49,447
SHOW YOU EXACTLY HOW WE'RE GOING

5688
03:40:49,447 --> 03:40:51,182
TO DO THAT WITH A BIG DATA 

5689
03:40:51,182 --> 03:40:51,883
APPROACH.

5690
03:40:51,883 --> 03:40:54,786
WE ARE EXPLORING NEW DIMENSIONS 

5691
03:40:54,786 --> 03:40:56,954
OF HUMAN DATA SPACE OF 

5692
03:40:56,954 --> 03:40:59,023
MEASUREMENTS AND TECHNOLOGIES, 

5693
03:40:59,023 --> 03:40:59,757
FUELED BY AI.

5694
03:40:59,757 --> 03:41:02,794
AND FINALLY, WE'RE GOING TO 

5695
03:41:02,794 --> 03:41:05,730
IDENTIFY PARTNERS THAT HAVE BOTH

5696
03:41:05,730 --> 03:41:07,031
PATIENTS AND RESOURCES THAT WILL

5697
03:41:07,031 --> 03:41:10,001
WORK TOGETHER WITH US AND I'LL 

5698
03:41:10,001 --> 03:41:12,270
INDICATE FOUR OR FIVE PARTNERS 

5699
03:41:12,270 --> 03:41:13,538
WE'VE IDENTIFIED SO FAR.

5700
03:41:13,538 --> 03:41:16,574
SO ON THE NEXT SLIDE IS GIVEN 

5701
03:41:16,574 --> 03:41:19,143
THE KIND OF DATA WE ARE GOING TO

5702
03:41:19,143 --> 03:41:23,581
USE IN THE PHENOMIC STUDIES WE 

5703
03:41:23,581 --> 03:41:25,082
ARE JUST BEGINNING AT THIS POINT

5704
03:41:25,082 --> 03:41:25,850
IN TIME.

5705
03:41:25,850 --> 03:41:26,751
NEXT SLIDE, PLEASE.

5706
03:41:26,751 --> 03:41:28,719
ON THE ONE HAND, IT IS THE 

5707
03:41:28,719 --> 03:41:32,824
THINGS WE DIDN'T IN ARIVALE, BUT

5708
03:41:32,824 --> 03:41:34,025
WE ARE DOING BRAIN HEALTH 

5709
03:41:34,025 --> 03:41:35,226
COGNITION STUDY THAT IS NEW AND 

5710
03:41:35,226 --> 03:41:37,662
WE ARE LOOKING AT SOCIAL 

5711
03:41:37,662 --> 03:41:40,298
DETERMINANTS ON HEALTH AND WE'RE

5712
03:41:40,298 --> 03:41:42,200
GOING TO BE USING ELECTRONIC 

5713
03:41:42,200 --> 03:41:44,001
HEALTH RECORDS AS MANY OTHERS 

5714
03:41:44,001 --> 03:41:44,802
HAVE.

5715
03:41:44,802 --> 03:41:47,905
AND ADDITIONAL WEARABLES THAT 

5716
03:41:47,905 --> 03:41:53,177
GIVE US VALUABLE PHYSIOLOGIC 

5717
03:41:53,177 --> 03:41:53,711
ANALY

5718
03:41:53,711 --> 03:41:53,978
ANALYSES.

5719
03:41:53,978 --> 03:41:56,380
WE HAVE A WHOLE SERIES OF NEW 

5720
03:41:56,380 --> 03:41:56,747
ANALYSES.

5721
03:41:56,747 --> 03:41:58,482
I'M ONLY GOING TO MENTION THEM 

5722
03:41:58,482 --> 03:41:59,684
HOPEFULLY BRIEFLY.

5723
03:41:59,684 --> 03:42:05,289
SO ON THE NEXT CLICK ONE OF THE 

5724
03:42:05,289 --> 03:42:08,125
ANALYSES IS THE ABILITY TO 

5725
03:42:08,125 --> 03:42:09,894
ASSESS INNATE -- CAN I GET THE 

5726
03:42:09,894 --> 03:42:11,495
NEXT CLICK, PLEASE.

5727
03:42:11,495 --> 03:42:17,335
INNATE AND ADAPTIVE IMMUNITY.

5728
03:42:17,335 --> 03:42:18,936
BY USING MORE THAN 10 TIMES THE 

5729
03:42:18,936 --> 03:42:22,673
DATA WE HAVE ON INDIVIDUALS.

5730
03:42:22,673 --> 03:42:28,212
WE'LL USE POLYGENIC SCORES, 

5731
03:42:28,212 --> 03:42:30,948
SINGLE CELL ANALYSES TO ASSESS 

5732
03:42:30,948 --> 03:42:33,284
INNATE AND ADAPTIVE IMMUNITY.

5733
03:42:33,284 --> 03:42:33,818
NEXT CLICK.

5734
03:42:33,818 --> 03:42:38,256
WE WILL USE A NEW MULTISPECTRAL 

5735
03:42:38,256 --> 03:42:42,026
DEVICE TO ANALYZE SALIVA AND 

5736
03:42:42,026 --> 03:42:45,229
DISTINGUISH NORMAL AND COVID 

5737
03:42:45,229 --> 03:42:46,264
INFECTED INDIVIDUALS IN THREE 

5738
03:42:46,264 --> 03:42:46,898
SECONDS WITH THIS.

5739
03:42:46,898 --> 03:42:48,432
WE ARE GOING TO USE A NEW 

5740
03:42:48,432 --> 03:42:50,935
STRUCTURE OF PROTEINS, ALPHA 

5741
03:42:50,935 --> 03:42:54,305
STRUCTURES THAT ARE ALLOWING US 

5742
03:42:54,305 --> 03:42:58,042
EXTREMELY EARLY DETECTION OF 

5743
03:42:58,042 --> 03:42:59,710
NEURODEGENERATIVE DISEASES THAT 

5744
03:42:59,710 --> 03:43:01,479
CREATE SPECIAL KINDS OF 

5745
03:43:01,479 --> 03:43:03,915
STRUCTURES AND ON THE NEXT SLIDE

5746
03:43:03,915 --> 03:43:06,117
WE'RE LOOKING AT BRAIN HEALTH 

5747
03:43:06,117 --> 03:43:09,420
AND COGNITION AND WE'LL TALK 

5748
03:43:09,420 --> 03:43:11,322
ABOUT THAT A LITTLE BIT LATER.

5749
03:43:11,322 --> 03:43:13,224
ON THE NEXT SLIDE WE HAVE AN EP 

5750
03:43:13,224 --> 03:43:19,764
NOR -- ENORMOUSLY EFFECTIVE NEW 

5751
03:43:19,764 --> 03:43:23,234
APPROACH WITH THE STANFORD 

5752
03:43:23,234 --> 03:43:25,903
COLLABORATOR USING -- TO GIVE 

5753
03:43:25,903 --> 03:43:28,105
VERY SUBTLE TAB LIKE DETECTIONS 

5754
03:43:28,105 --> 03:43:30,308
AND HE'S DEVELOPED A WONDERFUL 

5755
03:43:30,308 --> 03:43:32,410
DEVICE THAT CAN TAKE A DROP OF 

5756
03:43:32,410 --> 03:43:35,780
BLOOD AT HOME AND DETECT 30 OR 

5757
03:43:35,780 --> 03:43:37,882
40 DIFFERENT METABOLITES.

5758
03:43:37,882 --> 03:43:41,852
WHICH MAKES IT VERY RELEVANT TO 

5759
03:43:41,852 --> 03:43:43,220
STUDY METABOLIC DISEASES AND 

5760
03:43:43,220 --> 03:43:46,023
THINGS LIKE THAT.

5761
03:43:46,023 --> 03:43:54,298
AND THEN FROM LUX EMBORG WE HAVE

5762
03:43:54,298 --> 03:43:56,167
SPECTACULAR VOICE AND HAIR 

5763
03:43:56,167 --> 03:43:56,434
ANALYSIS.

5764
03:43:56,434 --> 03:44:01,806
EVERY CENTIMETER OF HAIR IS A 

5765
03:44:01,806 --> 03:44:03,240
MEASUREMENT OF MULTIPLE MONTHS 

5766
03:44:03,240 --> 03:44:06,110
OF MORE THAN 150 METABOLIC 

5767
03:44:06,110 --> 03:44:09,080
CONTAMINANTS THAT EXIST IN THE 

5768
03:44:09,080 --> 03:44:09,480
ENVIRONMENT.

5769
03:44:09,480 --> 03:44:12,016
AND THEY HAVE USED THAT TO THE 

5770
03:44:12,016 --> 03:44:16,654
EXTENT THEY CAN ACTUALLY LOCATE 

5771
03:44:16,654 --> 03:44:19,590
THE INDIVIDUAL LIVING LOCATION 

5772
03:44:19,590 --> 03:44:22,360
IN 14 DIFFERENT CLINICAL 

5773
03:44:22,360 --> 03:44:26,464
LOCATIONS IN LKS UXEMBORG AND 

5774
03:44:26,464 --> 03:44:27,832
SWITZERLAND, FRANCE AND BELGIUM.

5775
03:44:27,832 --> 03:44:30,301
BASED ON THE CONTAMINANTS THE 

5776
03:44:30,301 --> 03:44:31,002
INDIVIDUAL SHOWS.

5777
03:44:31,002 --> 03:44:33,604
IT IS A REALLY POWERFUL NEW 

5778
03:44:33,604 --> 03:44:33,871
APPROACH.

5779
03:44:33,871 --> 03:44:37,508
ON THE NEXT SLIDE, WE'LL TALK 

5780
03:44:37,508 --> 03:44:40,344
ABOUT POLYGENIC SCORES AND THE 

5781
03:44:40,344 --> 03:44:41,779
REASON THEY ARE SO IMPORTANT IS 

5782
03:44:41,779 --> 03:44:43,481
BECAUSE I THINK IT IS VERY 

5783
03:44:43,481 --> 03:44:48,419
VALUABLE IF WE ARE LOOKING AT 

5784
03:44:48,419 --> 03:44:51,389
ALCOHOL AND DRUG ADDICTIONS AND 

5785
03:44:51,389 --> 03:44:52,156
SO FORTH.

5786
03:44:52,156 --> 03:44:56,994
SO YOU CAN TAKE A POLYGENIC 

5787
03:44:56,994 --> 03:44:58,696
SCORE IF YOU HAVE THE FULL 

5788
03:44:58,696 --> 03:45:00,898
GENOME ANALYSIS AND CONVERT THAT

5789
03:45:00,898 --> 03:45:04,335
ON THE NEXT CLICK INTO GENETIC 

5790
03:45:04,335 --> 03:45:04,535
RISK.

5791
03:45:04,535 --> 03:45:06,537
ON THE NEXT CLICK THAT YOU SEE 

5792
03:45:06,537 --> 03:45:09,673
HERE, GENETIC RISK IS PLOTTED ON

5793
03:45:09,673 --> 03:45:12,309
INCREASING RISK ON THE X AXIS 

5794
03:45:12,309 --> 03:45:14,278
AND CLINICAL SCIENCE ON THE Y 

5795
03:45:14,278 --> 03:45:14,545
AXIS.

5796
03:45:14,545 --> 03:45:17,681
AND WHAT YOU CAN SEE IS THERE'S 

5797
03:45:17,681 --> 03:45:21,185
AN EXPONENTIAL INCREASE FOR FOUR

5798
03:45:21,185 --> 03:45:23,254
DIFFERENT DISEASE CONDITIONS.

5799
03:45:23,254 --> 03:45:26,891
THIS WAS FROM A 2018 PAPER THAT 

5800
03:45:26,891 --> 03:45:29,727
STUDIED BRITISH BIOBANK 

5801
03:45:29,727 --> 03:45:30,327
INFORMATION.

5802
03:45:30,327 --> 03:45:32,930
AND WHAT I'LL ARGUE IS WE CAN DO

5803
03:45:32,930 --> 03:45:37,134
EXACTLY THE SAME THING FOR THE 

5804
03:45:37,134 --> 03:45:39,370
POLYGENIC SCORES THAT NOW EXIST 

5805
03:45:39,370 --> 03:45:40,838
FOR ALCOHOLISM AND FOR DRUG 

5806
03:45:40,838 --> 03:45:44,041
ADDICTION AND SO FORTH.

5807
03:45:44,041 --> 03:45:47,111
AND THE NEXT THING WE DID IS TO 

5808
03:45:47,111 --> 03:45:51,248
REPLACE CLINICAL FEATURES ON THE

5809
03:45:51,248 --> 03:45:54,185
Y AXIS WITH LOOKING AT ROUGHLY 

5810
03:45:54,185 --> 03:45:55,586
800 DIFFERENT METABOLITES IN THE

5811
03:45:55,586 --> 03:45:57,922
BLOOD AND SEEING HOW THEY 

5812
03:45:57,922 --> 03:46:00,024
CHANGED FOR EACH -- ON THE NEXT 

5813
03:46:00,024 --> 03:46:04,128
SLIDE -- OF 54 DIFFERENT 

5814
03:46:04,128 --> 03:46:06,730
POLYGENIIC SCORES WE EXAMINED IN

5815
03:46:06,730 --> 03:46:09,834
THE ARIVALE POPULATION.

5816
03:46:09,834 --> 03:46:11,102
THE REALLY STRIKING THING ON THE

5817
03:46:11,102 --> 03:46:13,370
NEXT SLIDE WAS THAT IN EACH CASE

5818
03:46:13,370 --> 03:46:21,078
FOR EACH OF THE 54 DISEASES AND 

5819
03:46:21,078 --> 03:46:22,480
NOR

5820
03:46:22,480 --> 03:46:26,183
NORMAL PHENOTYPES WE SAW 

5821
03:46:26,183 --> 03:46:28,953
INCREASES OR DECREASES IN 

5822
03:46:28,953 --> 03:46:30,054
METABOLITES WHERE WE KNEW WERE 

5823
03:46:30,054 --> 03:46:31,822
RELATED TO THE FEATURES OF THE 

5824
03:46:31,822 --> 03:46:33,824
DISEASE THAT WAS BEING STUDIED.

5825
03:46:33,824 --> 03:46:36,994
I'LL ARGUE THAT SMOKING AND 

5826
03:46:36,994 --> 03:46:38,796
ADDICTION HAVE THESE SAME KIND 

5827
03:46:38,796 --> 03:46:42,666
OF POLYGENIC SCORES.

5828
03:46:42,666 --> 03:46:45,870
SO WHAT WE DID WITH THIS 

5829
03:46:45,870 --> 03:46:47,972
INFORMATION THEN ON THE NEXT 

5830
03:46:47,972 --> 03:46:51,642
SLIDE IS LOOK AT LDL CHOLESTEROL

5831
03:46:51,642 --> 03:46:55,379
THAT POLYGENIC TRAIT OF 

5832
03:46:55,379 --> 03:46:56,180
INCREASING RISK FOR THAT.

5833
03:46:56,180 --> 03:46:59,817
IN THE ARIVALE POPULATION, AND 

5834
03:46:59,817 --> 03:47:02,153
WE SHOWS FOR INDIVIDUALS NOT ON 

5835
03:47:02,153 --> 03:47:08,225
STATENS WITH INCREASED GENETIC 

5836
03:47:08,225 --> 03:47:08,559
RISK.

5837
03:47:08,559 --> 03:47:11,295
THE REALLY IMPORTANT POINT WAS 

5838
03:47:11,295 --> 03:47:14,231
THOSE THAT HAD HIGH GENETIC RISK

5839
03:47:14,231 --> 03:47:16,600
AND HIGH CHOLESTEROL IT ONLY 

5840
03:47:16,600 --> 03:47:18,969
COULD BE BROUGHT DOWN BY 

5841
03:47:18,969 --> 03:47:20,738
STATINS, BY CHEMISTRY.

5842
03:47:20,738 --> 03:47:22,806
WHEREAS THOSE THAT HAD LOW 

5843
03:47:22,806 --> 03:47:24,375
GENETIC RISK AND HIGH 

5844
03:47:24,375 --> 03:47:25,809
CHOLESTEROL, DIET AND EXERCISE 

5845
03:47:25,809 --> 03:47:28,012
BROUGHT IT DOWN VERY WELL.

5846
03:47:28,012 --> 03:47:30,915
WE THINK FOR MOST OF THE 

5847
03:47:30,915 --> 03:47:32,716
DISEASES, YOU'RE GOING TO TREAT 

5848
03:47:32,716 --> 03:47:35,886
HIGH AND LOW RISK PEOPLE VERY 

5849
03:47:35,886 --> 03:47:36,353
DIFFERENTLY.

5850
03:47:36,353 --> 03:47:38,923
AND THAT MEANS DOCTORS SHOULD 

5851
03:47:38,923 --> 03:47:41,058
KNOW THE GENETIC RISKS OF THE 

5852
03:47:41,058 --> 03:47:42,960
PATIENTS THEY ARE DEALING WITH 

5853
03:47:42,960 --> 03:47:44,728
FOR AS MANY DISEASES AS 

5854
03:47:44,728 --> 03:47:44,995
POSSIBLE.

5855
03:47:44,995 --> 03:47:50,834
AND FRANKLY, I WOULD ARGUE GIVEN

5856
03:47:50,834 --> 03:47:53,637
THE GENETIC RISK TO THE 

5857
03:47:53,637 --> 03:47:56,840
PHYSICIANS ALONE IS PROBABLY 

5858
03:47:56,840 --> 03:47:59,176
ADVISABLE, UNLESS THE PATIENT 

5859
03:47:59,176 --> 03:48:01,512
REALLY WANTED -- MANY OF THEM 

5860
03:48:01,512 --> 03:48:02,813
WORRY IF THEY KNOW THESE KINDS 

5861
03:48:02,813 --> 03:48:03,314
OF THINGS.

5862
03:48:03,314 --> 03:48:05,883
ON THE NEXT CLICK A REALLY 

5863
03:48:05,883 --> 03:48:08,219
IMPORTANT QUESTION IS, YOU KNOW,

5864
03:48:08,219 --> 03:48:11,288
THE POPULATION WE LOOKED AT IN 

5865
03:48:11,288 --> 03:48:17,261
ARIVALE WAS MOSTLY 40s, 50s, 

5866
03:48:17,261 --> 03:48:19,296
60s.

5867
03:48:19,296 --> 03:48:21,799
SO A KEY QUESTION IS WHEN DOES 

5868
03:48:21,799 --> 03:48:27,004
THE HIGH GENETIC RISK MANIFEST 

5869
03:48:27,004 --> 03:48:27,671
ITSELF?

5870
03:48:27,671 --> 03:48:30,307
WITH HIGH LDL CHOLESTEROL IT 

5871
03:48:30,307 --> 03:48:31,375
DOESN'T HAPPEN IN THE YOUNG 

5872
03:48:31,375 --> 03:48:33,077
UNTIL LATER ON.

5873
03:48:33,077 --> 03:48:37,047
WE HAD AN AIRVALE ONE INDIVIDUAL

5874
03:48:37,047 --> 03:48:39,316
ON THE NEXT SLIDE, PLEASE.

5875
03:48:39,316 --> 03:48:44,255
THAT HAD A SLIDE THAT HAD A 

5876
03:48:44,255 --> 03:48:46,924
FAMILY HISTORY OF THREE 

5877
03:48:46,924 --> 03:48:48,158
GENERATIONS OF PATERNAL 

5878
03:48:48,158 --> 03:48:49,994
INDIVIDUALS DYING BEFORE THEY 

5879
03:48:49,994 --> 03:48:52,563
WERE 50 OF HEART ATTACKS.

5880
03:48:52,563 --> 03:48:55,366
AND WHAT HE DID WAS IN HIS TEENS

5881
03:48:55,366 --> 03:48:58,235
STARTED FOLLOWING HIS LDL 

5882
03:48:58,235 --> 03:48:58,602
CHOLESTEROL.

5883
03:48:58,602 --> 03:49:01,272
WHAT HE WAS ABLE TO SHOW ON THE 

5884
03:49:01,272 --> 03:49:04,208
NEXT CLICK IS THAT IT STAYED 

5885
03:49:04,208 --> 03:49:06,143
VERY LOW UNTIL THE MID 30s AND 

5886
03:49:06,143 --> 03:49:07,278
THEN IT SHOT UP.

5887
03:49:07,278 --> 03:49:08,479
HE WAS YOUNG.

5888
03:49:08,479 --> 03:49:10,247
HE WAS ATHLETIC.

5889
03:49:10,247 --> 03:49:11,615
HE DIDN'T CHANGE HIS DIET.

5890
03:49:11,615 --> 03:49:13,851
IT WAS SOMETHING INTRINSIC AND 

5891
03:49:13,851 --> 03:49:15,786
THE ONLY WAY HE COULD BRING IT 

5892
03:49:15,786 --> 03:49:20,991
DOWN ON THE NEXT CLICK WAS WITH 

5893
03:49:20,991 --> 03:49:21,225
STATINS.

5894
03:49:21,225 --> 03:49:23,761
WE WILL KNOW FOR ALL OF THESE 

5895
03:49:23,761 --> 03:49:26,397
DISEASES THE ANALYTES ON THE 

5896
03:49:26,397 --> 03:49:28,932
NEXT CLICK, PLEASE.

5897
03:49:28,932 --> 03:49:30,634
WE'LL KNOW THE ANALYZE THAT WILL

5898
03:49:30,634 --> 03:49:34,972
MARK THE MANIFESTATION OF THE

5899
03:49:34,972 --> 03:49:42,079
YZ -- DISEASE AND THE FI KI -- 

5900
03:49:42,079 --> 03:49:42,946
PHYSICIAN CAN TREAT.

5901
03:49:42,946 --> 03:49:48,585
SO ON THE NEXT SLIDE I'M JUST 

5902
03:49:48,585 --> 03:49:49,953
MAKING THE STATEMENT THAT 

5903
03:49:49,953 --> 03:49:52,189
EXACTLY THE SAME IS GOING TO BE 

5904
03:49:52,189 --> 03:49:56,427
TRUE FOR GENETICS OR GENETIC 

5905
03:49:56,427 --> 03:49:58,729
RISK AND NICOTINE ADDICTION.

5906
03:49:58,729 --> 03:50:01,532
AND ONE OF THE REALLY 

5907
03:50:01,532 --> 03:50:05,703
INTERESTING THINGS IS THE 

5908
03:50:05,703 --> 03:50:07,871
POLYGENIC LOW CONTRIBUTIONS IN 

5909
03:50:07,871 --> 03:50:09,640
THE GENETIC VARIANTS THAT 

5910
03:50:09,640 --> 03:50:10,674
CONTRIBUTE TO A DISEASE.

5911
03:50:10,674 --> 03:50:12,142
IN THE CASE OF SEVERAL EXAMPLES 

5912
03:50:12,142 --> 03:50:18,382
WHERE WE KNOW A LOT ABOUT IT, 

5913
03:50:18,382 --> 03:50:21,885
NAMELY ALZHEIMER'S AND LDL 

5914
03:50:21,885 --> 03:50:24,054
CHOLESTEROL MAP INTO GENES THAT 

5915
03:50:24,054 --> 03:50:29,927
ARE RELEVANT TO THE GENETIC RISK

5916
03:50:29,927 --> 03:50:31,061
AT HAND.

5917
03:50:31,061 --> 03:50:32,930
I'M SURE EXACTLY IS GOING TO BE 

5918
03:50:32,930 --> 03:50:36,266
THE SAME IS GOING TO BE TRUE FOR

5919
03:50:36,266 --> 03:50:38,669
NICOTINE ADDICTION AND ON THE 

5920
03:50:38,669 --> 03:50:43,173
NEXT SLIDE THERE IS THE SAME 50%

5921
03:50:43,173 --> 03:50:46,643
OR SO ADDICTION FOR ALCOHOL AND 

5922
03:50:46,643 --> 03:50:48,145
THEY MAP INTO CERTAIN SETS OF 

5923
03:50:48,145 --> 03:50:49,413
GENES THAT CAN BE DONE.

5924
03:50:49,413 --> 03:50:52,282
AND ON THE NEXT SLIDE WE SHOW 

5925
03:50:52,282 --> 03:50:54,685
THAT THIS PUTS YOU IN A POSITION

5926
03:50:54,685 --> 03:50:56,854
TO LOOK AT THESE THINGS FROM THE

5927
03:50:56,854 --> 03:51:00,023
POINT OF VIEW OF POLYGENIC 

5928
03:51:00,023 --> 03:51:05,129
SCORES ON THE NEXT SLIDE.

5929
03:51:05,129 --> 03:51:06,930
IN A NUMBER OF DIFFERENT WAYS.

5930
03:51:06,930 --> 03:51:08,465
THAT IS THE SLIDE I DIDN'T GET 

5931
03:51:08,465 --> 03:51:09,233
IN THERE.

5932
03:51:09,233 --> 03:51:12,436
ANYWAY, WE CAN LOOK AT EARLY 

5933
03:51:12,436 --> 03:51:12,703
DETECTION.

5934
03:51:12,703 --> 03:51:14,905
WE CAN KNOW THAT HIGH AND LOW 

5935
03:51:14,905 --> 03:51:15,773
PEOPLE FOR THESE THINGS ARE 

5936
03:51:15,773 --> 03:51:18,375
GOING TO HAVE TO BE TREATED 

5937
03:51:18,375 --> 03:51:19,042
DIFFERENTLY AND, OF COURSE, YOU 

5938
03:51:19,042 --> 03:51:21,311
CAN THINK ABOUT WHAT TO DO WHEN 

5939
03:51:21,311 --> 03:51:31,755
YOU HAVE MANIFEST DISEASE.

5940
03:51:33,424 --> 03:51:35,926
THE AI I WILL MENTION, WE ARE 

5941
03:51:35,926 --> 03:51:38,429
INTERESTED IN AI LOOKING AT THE 

5942
03:51:38,429 --> 03:51:39,296
UNIQUENESS OF EACH INDIVIDUAL 

5943
03:51:39,296 --> 03:51:41,198
AND FROM THAT ASSESS AND 

5944
03:51:41,198 --> 03:51:42,266
PRIORITIZE THE ACTIONABLE 

5945
03:51:42,266 --> 03:51:42,900
POSSIBILITIES RELEVANT TO THAT 

5946
03:51:42,900 --> 03:51:53,110
INDIVIDUAL.

5947
03:51:56,079 --> 03:51:57,881
 WE FEED THE KNOWLEDGE GRAPH 

5948
03:51:57,881 --> 03:51:59,450
WITH INDIVIDUAL DIFFERENCES AND 

5949
03:51:59,450 --> 03:52:05,489
THEY MAP INTO THE COMMUNITIES 

5950
03:52:05,489 --> 03:52:09,393
AND THE NETWORKS, BIOLOGICAL 

5951
03:52:09,393 --> 03:52:10,394
NETWORKS AND THAT IS INFORMATION

5952
03:52:10,394 --> 03:52:14,798
THEN THAT CAN BE FED IN THE NEXT

5953
03:52:14,798 --> 03:52:17,234
SLIDE INTO TRANSFORMERS, INTO 

5954
03:52:17,234 --> 03:52:18,535
LARGE LANGUAGE MODELS.

5955
03:52:18,535 --> 03:52:20,170
HENCE, WE ARE GOING TO BE ABLE 

5956
03:52:20,170 --> 03:52:23,707
TO USE THE TRANSFORMER TO 

5957
03:52:23,707 --> 03:52:26,009
ACTUALLY LOOK AT INDIVIDUALS.

5958
03:52:26,009 --> 03:52:28,312
ON THE NEXT CLICK, PLEASE, IN 

5959
03:52:28,312 --> 03:52:30,914
THE CONTEXT OF EACH INDIVIDUAL 

5960
03:52:30,914 --> 03:52:33,884
AND PRIORITIZE THE ACTIONABLE 

5961
03:52:33,884 --> 03:52:36,286
POSSIBILITIES, SEND THOSE TO THE

5962
03:52:36,286 --> 03:52:36,587
PHYSICIAN.

5963
03:52:36,587 --> 03:52:41,291
AND THAT PHYSICIAN/AI 

5964
03:52:41,291 --> 03:52:44,027
PARTNERSHIP OPERATIONALLY MAKING

5965
03:52:44,027 --> 03:52:47,030
THE PHYSICIAN A DOMAIN EXPERT IN

5966
03:52:47,030 --> 03:52:49,333
MANY FIELDS OF MEDICINE AND 

5967
03:52:49,333 --> 03:52:52,803
HENCE BETTER TO DELIVER ACTION 

5968
03:52:52,803 --> 03:52:53,670
TO THE -- ACTIONABLE 

5969
03:52:53,670 --> 03:52:55,138
POSSIBILITIES TO THE PATIENTS.

5970
03:52:55,138 --> 03:52:58,609
AND WE'VE ALSO USED A CHATBOT 

5971
03:52:58,609 --> 03:53:00,911
THAT CAN BE USED FOR PATIENTS 

5972
03:53:00,911 --> 03:53:03,247
AND FOR PHYSICIANS THAT 

5973
03:53:03,247 --> 03:53:04,314
BASICALLY CAN ANSWER ANY 

5974
03:53:04,314 --> 03:53:07,551
QUESTION IN SIMPLE TERMS ABOUT 

5975
03:53:07,551 --> 03:53:09,019
DATA-DRIVEN HEALTH AND WE CAN 

5976
03:53:09,019 --> 03:53:10,153
TALK ABOUT THAT.

5977
03:53:10,153 --> 03:53:13,156
AND ON THE FINAL CLICK, I WILL 

5978
03:53:13,156 --> 03:53:14,925
JUST SAY FOR TWO DISEASES, 

5979
03:53:14,925 --> 03:53:17,461
ALZHEIMER'S AND DIABETES, WE 

5980
03:53:17,461 --> 03:53:19,763
HAVE DIGITAL TWINS THAT HAVE 

5981
03:53:19,763 --> 03:53:22,332
GIVEN US ENORMOUS BIG DATA 

5982
03:53:22,332 --> 03:53:23,967
INFORMATION THAT GIVE US NEW AND

5983
03:53:23,967 --> 03:53:27,137
POWERFUL INSIGHTS INTO THESE 

5984
03:53:27,137 --> 03:53:27,804
DISEASES.

5985
03:53:27,804 --> 03:53:31,174
AND WE'RE JUST SUBMITTING FOR 

5986
03:53:31,174 --> 03:53:32,776
PUBLICATION, A BIG NEW PAPER ON 

5987
03:53:32,776 --> 03:53:35,913
A DIGITAL TWIN ANALYSIS OF 

5988
03:53:35,913 --> 03:53:37,014
ALZHEIMER'S IN THE ALZHEIMER'S 

5989
03:53:37,014 --> 03:53:38,248
DATA THAT EXISTS.

5990
03:53:38,248 --> 03:53:42,052
THAT I THINK SAYS REALLY CLEARLY

5991
03:53:42,052 --> 03:53:44,721
ALZHEIMER'S IS FUNDAMENTALLY A 

5992
03:53:44,721 --> 03:53:46,189
METABOLIC DISEASE THAT HAS TO DO

5993
03:53:46,189 --> 03:53:48,525
WITH THE HANDLING OF CHOLESTEROL

5994
03:53:48,525 --> 03:53:50,294
AND WHAT IT DOES TO ENERGY 

5995
03:53:50,294 --> 03:53:53,196
DISTRIBUTION IN THE BRAIN.

5996
03:53:53,196 --> 03:53:58,702
SO ON THE NEXT SLIDE, WE HAVE 

5997
03:53:58,702 --> 03:54:00,871
TWO MAJOR AREAS THAT WE'RE 

5998
03:54:00,871 --> 03:54:02,773
REALLY INTERESTED IN.

5999
03:54:02,773 --> 03:54:07,811
IN THE FIRST CLICK, WE'RE AS IN 

6000
03:54:07,811 --> 03:54:10,981
ARIVALE LOOKING AT INDIVIDUALS 

6001
03:54:10,981 --> 03:54:17,187
AND THEIR GENOME, PHENOMES OVER 

6002
03:54:17,187 --> 03:54:19,690
LARGE PERIODS OF TIME AS IN THE 

6003
03:54:19,690 --> 03:54:21,058
MILLION PERSON PROJECT.

6004
03:54:21,058 --> 03:54:22,726
THE INTERNATIONAL PROJECT AND 

6005
03:54:22,726 --> 03:54:29,099
THE U.S. PROJECT I'M PUSHING ARE

6006
03:54:29,099 --> 03:54:30,534
TWO DIFFERENT POSSIBILITIES.

6007
03:54:30,534 --> 03:54:33,604
IN THE SECOND CATEGORY WE HAVE 

6008
03:54:33,604 --> 03:54:44,181
TAKEN -- NEXT CLICK, PLEASE, WE 

6009
03:54:44,181 --> 03:54:44,815
HAVE TAKEN A BIG DATA APPROACH 

6010
03:54:44,815 --> 03:54:45,349
TO THE FOUR MAJOR CHRONIC 

6011
03:54:45,349 --> 03:54:45,983
DISEASES AND WE'VE STARTED WITH 

6012
03:54:45,983 --> 03:54:46,483
A BIG TRIAL ON DIABETES.

6013
03:54:46,483 --> 03:54:47,117
AND WE'RE JUST GETTING STARTED 

6014
03:54:47,117 --> 03:54:48,251
WITH THE SECOND TRIAL ON 

6015
03:54:48,251 --> 03:54:48,552
ALZHEIMER'S.

6016
03:54:48,552 --> 03:54:51,054
AND WE WANT TO DO THREE THINGS.

6017
03:54:51,054 --> 03:54:54,391
ONE, VERY EARLY DETECTION.

6018
03:54:54,391 --> 03:54:56,793
TWO, DEFINE WITH OMICS THE 

6019
03:54:56,793 --> 03:54:59,830
SUBTYPES AND THE MAJOR 

6020
03:54:59,830 --> 03:55:01,865
TRANSITION FROM EACH SUBTYPE TO 

6021
03:55:01,865 --> 03:55:07,237
RELEVANT PATHOLOGIES AND THEN 

6022
03:55:07,237 --> 03:55:09,706
THREE, THE MATCHES BETWEEN 

6023
03:55:09,706 --> 03:55:12,709
SUBTYPES AND DRUGS OR BEHAVIORAL

6024
03:55:12,709 --> 03:55:14,578
LIFESTYLE CHANGES THAT WILL 

6025
03:55:14,578 --> 03:55:17,214
REVERSE THEM AT AN EARLY STAGE.

6026
03:55:17,214 --> 03:55:18,782
ON THE NEXT SLIDE ARE SHOWING 

6027
03:55:18,782 --> 03:55:20,851
THE THINGS THAT WE ARE ACTUALLY 

6028
03:55:20,851 --> 03:55:21,985
DOING RIGHT NOW.

6029
03:55:21,985 --> 03:55:24,955
AND THE FIRST, OF COURSE, WAS AN

6030
03:55:24,955 --> 03:55:27,491
ARPA H GRANT WE GOT FOR $52 

6031
03:55:27,491 --> 03:55:37,901
MILLION ON THE NEXT SLIDE, 

6032
03:55:37,901 --> 03:55:38,135
PLEASE.

6033
03:55:38,135 --> 03:55:38,502
OVER FIVE YEARS.

6034
03:55:38,502 --> 03:55:39,169
TO BE ABLE -- FOUR YEARS, TO BE 

6035
03:55:39,169 --> 03:55:45,108
ABLE TO LOOK AT THE RISEN ON 

6036
03:55:45,108 --> 03:55:50,847
ANALYNES IN THE BLOOD TO LARGE 

6037
03:55:50,847 --> 03:55:51,448
PHENOMIC SETS.

6038
03:55:51,448 --> 03:55:53,517
WE HAVE THREE LARGE SETS ONE 

6039
03:55:53,517 --> 03:55:56,153
FROM TURKEY THAT HAS 10,000 

6040
03:55:56,153 --> 03:55:58,388
INDIVIDUALS AND ONE FROM ISRAEL 

6041
03:55:58,388 --> 03:55:59,856
THAT HAS ABOUT 15,000 

6042
03:55:59,856 --> 03:56:00,157
INDIVIDUALS.

6043
03:56:00,157 --> 03:56:02,926
WE ARE HARMONIZING THEM AND 

6044
03:56:02,926 --> 03:56:05,128
STANDARDIZING THEM AND 

6045
03:56:05,128 --> 03:56:06,396
EXTRAPOLATING MISSING DATA IN 

6046
03:56:06,396 --> 03:56:07,064
THOSE SETS.

6047
03:56:07,064 --> 03:56:09,433
THREE, WE ARE TAKING A BIG DATA 

6048
03:56:09,433 --> 03:56:13,537
APPROACH TO A 15-YEAR TYPE 2 

6049
03:56:13,537 --> 03:56:16,006
DIABETES STUDY WHERE EVERY THREE

6050
03:56:16,006 --> 03:56:18,742
YEARS THEY HAVE MASSIVE CLINICAL

6051
03:56:18,742 --> 03:56:22,112
DATA WITH BLOOD DRAWS AND 

6052
03:56:22,112 --> 03:56:24,748
CONVERTING THAT INTO AN OMIC 

6053
03:56:24,748 --> 03:56:27,451
STUDY THAT SHOULD BE INFORMATIVE

6054
03:56:27,451 --> 03:56:30,053
ACROSS THE ENTIRE LIFE HISTORY.

6055
03:56:30,053 --> 03:56:32,823
THEY TOOK 400 INDIVIDUALS, 

6056
03:56:32,823 --> 03:56:34,591
NORMAL, 70 CONVERTED.

6057
03:56:34,591 --> 03:56:37,160
WE WILL LOOK AT 70 THAT 

6058
03:56:37,160 --> 03:56:38,695
CONVERTED AND 70 THAT FAILED TO 

6059
03:56:38,695 --> 03:56:40,897
CONVERT TO SEE THE DIFFERENCES.

6060
03:56:40,897 --> 03:56:45,235
WE ARE DOING AN IMPEDENCE MATCH 

6061
03:56:45,235 --> 03:56:48,004
BETWEEN OMICS AND TWO CLASSES OF

6062
03:56:48,004 --> 03:56:48,271
WEARABLES.

6063
03:56:48,271 --> 03:56:51,775
ALL OF THE WEARABLES HAVE 

6064
03:56:51,775 --> 03:56:53,376
ENORMOUS DIMENSIONS OF DATA THAT

6065
03:56:53,376 --> 03:56:58,915
ARE UNRECOGNIZED AND DOING THESE

6066
03:56:58,915 --> 03:57:03,854
IN PASHS EDS MATCHES CAN TAKE 

6067
03:57:03,854 --> 03:57:09,760
WEARABLES TO AT-HOME TO ANALYZE 

6068
03:57:09,760 --> 03:57:10,794
THE THINGS.

6069
03:57:10,794 --> 03:57:15,465
WE WANT TO DEMOCRATIZE 

6070
03:57:15,465 --> 03:57:19,102
PHENOMICS.

6071
03:57:19,102 --> 03:57:28,578
WE ARE DOING A IN KWAULS 1 

6072
03:57:28,578 --> 03:57:30,380
ANALYA -- N

6073
03:57:30,380 --> 03:57:30,981
EQUALS 1.

6074
03:57:30,981 --> 03:57:33,683
WE ARE LOOKING AT TYPE TWO 

6075
03:57:33,683 --> 03:57:33,950
DIABETES.

6076
03:57:33,950 --> 03:57:35,952
I CAN'T SEE THAT.

6077
03:57:35,952 --> 03:57:36,153
THERE.

6078
03:57:36,153 --> 03:57:38,488
WE JUST GOT FUNDING TO CARRY 

6079
03:57:38,488 --> 03:57:41,558
THAT OUT AND WE'RE DOING THAT 

6080
03:57:41,558 --> 03:57:42,926
WITH GUARDIAN RESEARCH NETWORK 

6081
03:57:42,926 --> 03:57:43,460
IN SOUTH CAROLINA.

6082
03:57:43,460 --> 03:57:47,397
AND AGAIN, THE IDEA IS EARLY 

6083
03:57:47,397 --> 03:57:51,601
DETECTION, SUBTYPES AND 

6084
03:57:51,601 --> 03:57:55,138
APPROPRIATE IMPEDENCE MATCH OF 

6085
03:57:55,138 --> 03:57:57,641
THERAPIES ESPECIALLY FOR EARLY 

6086
03:57:57,641 --> 03:57:57,941
REVERSAL.

6087
03:57:57,941 --> 03:58:00,911
ON THE NEXT SIDE WE HAVE BEEN 

6088
03:58:00,911 --> 03:58:03,413
DOING A PREGNANCY STUDY FOR MORE

6089
03:58:03,413 --> 03:58:08,418
THAN FIVE YEARS NOW WITH 

6090
03:58:08,418 --> 03:58:09,953
SEDOOWSKY AT THE UNIVERSITY OF 

6091
03:58:09,953 --> 03:58:11,955
PITTSBURGH, WHERE WE HAVE TAKEN 

6092
03:58:11,955 --> 03:58:13,456
150 SUGGESTS THROUGH AND 

6093
03:58:13,456 --> 03:58:15,325
GATHERED FIVE BLOOD SAMPLES 

6094
03:58:15,325 --> 03:58:16,693
ACROSS PREGNANCY AT THE 

6095
03:58:16,693 --> 03:58:18,328
UNIVERSITY OF PITTSBURGH AND WE 

6096
03:58:18,328 --> 03:58:21,431
ARE JUST NOW BEGUNNING TO 

6097
03:58:21,431 --> 03:58:31,675
ANALYZE THOSE 

6098
03:58:57,467 --> 03:59:05,141
SO ON THE NEXT SLIDE THEN LET'S 

6099
03:59:05,141 --> 03:59:08,245
TALK ABOUT -- CAN WE GET THE 

6100
03:59:08,245 --> 03:59:10,113
NEXT SLIDE, PLEASE.

6101
03:59:10,113 --> 03:59:13,817
THE FACT, DATA DRIVEN HEALTH 

6102
03:59:13,817 --> 03:59:15,418
ACTUALLY OFFERS SOLUTIONS FOR 

6103
03:59:15,418 --> 03:59:19,623
EACH OF THE FIVE CHALLENGES OF 

6104
03:59:19,623 --> 03:59:21,558
CONTEMPORARY HEALTH CARE, NAMELY

6105
03:59:21,558 --> 03:59:24,961
QUALITY OF CARE, EXPANDING AGING

6106
03:59:24,961 --> 03:59:27,397
POPULATION, EXPLOSION OF CHRONIC

6107
03:59:27,397 --> 03:59:30,500
DISEASES, THE LACK OF DIVERSITY 

6108
03:59:30,500 --> 03:59:33,203
AND THIS IS STILL KEY WHATEVER 

6109
03:59:33,203 --> 03:59:35,872
TRUMP MAY THINK AND THEN EX

6110
03:59:35,872 --> 03:59:37,707
EXPONENTIALLY INCREASING COSTS.

6111
03:59:37,707 --> 03:59:39,876
ON THE NEXT SLIDE ARE THE FOUR 

6112
03:59:39,876 --> 03:59:42,579
REASONS WHY I THINK DATA-DRIVEN 

6113
03:59:42,579 --> 03:59:43,580
SCIENCE ARE GOING TO GIVE US 

6114
03:59:43,580 --> 03:59:45,515
TRILLIONS OF DOLLARS OF SAVINGS 

6115
03:59:45,515 --> 03:59:49,252
IN THE NEXT 10 YEARS OF CON 

6116
03:59:49,252 --> 03:59:49,953
TEMPORARY HEALTH CARE.

6117
03:59:49,953 --> 03:59:52,255
SO IN THE FIRST CLICK, IT IS THE

6118
03:59:52,255 --> 04:00:01,965
IDEA BY KEEPI IING PEEL  -- PEO 

6119
04:00:01,965 --> 04:00:02,165
WELL.

6120
04:00:02,165 --> 04:00:03,466
CAN WE CLICK AGAIN SO YOU CAN 

6121
04:00:03,466 --> 04:00:04,968
SEE IT.

6122
04:00:04,968 --> 04:00:06,536
JUST AVOIDING DISEASE.

6123
04:00:06,536 --> 04:00:09,139
ON THE NEXT CLICK THE IDEA OF 

6124
04:00:09,139 --> 04:00:11,308
BEING ABLE TO DETECT EARLY.

6125
04:00:11,308 --> 04:00:15,211
CAN WE CLICK AGAIN SO WE CAN 

6126
04:00:15,211 --> 04:00:15,779
SEE.

6127
04:00:15,779 --> 04:00:18,381
LOOKING AT THE EARLY TRANSITIONS

6128
04:00:18,381 --> 04:00:20,917
AND REVERSAL OF CHRONIC DISEASES

6129
04:00:20,917 --> 04:00:22,552
AND WE HAVE THREE DIFFERENT 

6130
04:00:22,552 --> 04:00:24,854
APPROACHES, I TALKED ABOUT IT.

6131
04:00:24,854 --> 04:00:29,659
OPTIMIZING DRUG USES FOR 

6132
04:00:29,659 --> 04:00:29,960
INDIVIDUAL.

6133
04:00:29,960 --> 04:00:33,129
THERE WAS A 2015 NATURE PAPER 

6134
04:00:33,129 --> 04:00:34,397
THAT SHOWED FOR THE 10 MOST 

6135
04:00:34,397 --> 04:00:37,000
COMMON DRUGS, LESS THAN 10% OF 

6136
04:00:37,000 --> 04:00:38,935
THE INDIVIDUALS HAD REALLY 

6137
04:00:38,935 --> 04:00:41,771
EFFECTIVE RESPONSES AT A COST OF

6138
04:00:41,771 --> 04:00:44,007
$600 BILLION PER YEAR.

6139
04:00:44,007 --> 04:00:46,776
I SUPPOSE YOU COULD MAKE IT A 

6140
04:00:46,776 --> 04:00:47,978
PERFECT MATCH OF SUCCESS.

6141
04:00:47,978 --> 04:00:50,513
AND THEN BRINGING THE INSIGHTS 

6142
04:00:50,513 --> 04:00:52,482
FROM THESE BIG DATA APPROACHED 

6143
04:00:52,482 --> 04:00:57,153
TO CHRONIC DISEASE I THINK WILL 

6144
04:00:57,153 --> 04:00:58,922
LEAD TO ENORMOUS CHANGES AS WELL

6145
04:00:58,922 --> 04:01:01,157
AS KNOWING THE NORMAL PHYSIOLOGY

6146
04:01:01,157 --> 04:01:02,192
OF PREGNANCY AND SOMETHING WE 

6147
04:01:02,192 --> 04:01:04,928
ARE JUST GETTING STARTED ON, 

6148
04:01:04,928 --> 04:01:05,695
EARLY CHILDHOOD DEVELOPMENT.

6149
04:01:05,695 --> 04:01:08,832
SO ON THE NEXT SLIDE THEN LET ME

6150
04:01:08,832 --> 04:01:12,135
JUST SAY THAT THE MILLION PERSON

6151
04:01:12,135 --> 04:01:15,271
PROJECT ACTUALLY AND CLICK AGAIN

6152
04:01:15,271 --> 04:01:18,274
GIVES US THE FOUR BENEFITS I 

6153
04:01:18,274 --> 04:01:19,109
MENTIONED EARLIER.

6154
04:01:19,109 --> 04:01:23,913
IT WILL UNEQUIVOCALLY IMPROVE, 

6155
04:01:23,913 --> 04:01:27,217
VALIDATE INCREASED HEALTH FOR 

6156
04:01:27,217 --> 04:01:29,319
THE INDIVIDUAL.

6157
04:01:29,319 --> 04:01:32,155
IT WILL LEAD TO ENORMOUS -- CAN 

6158
04:01:32,155 --> 04:01:34,491
WE HAVE THE CLICK PLEASE.

6159
04:01:34,491 --> 04:01:37,794
ENORMOUS COST SAVINGS.

6160
04:01:37,794 --> 04:01:40,597
C

6161
04:01:40,597 --> 04:01:44,134
CATALYZE NEW APPROACHES OF HOME 

6162
04:01:44,134 --> 04:01:46,469
TYPES AND SALIVA AND GENERATING 

6163
04:01:46,469 --> 04:01:50,407
TENS OF THOUSANDS OF ACTIONABLE 

6164
04:01:50,407 --> 04:01:53,276
POSSIBILITIES AND DRUG TARGETS 

6165
04:01:53,276 --> 04:01:55,845
FOR WELLNESS AND PREVENTION.

6166
04:01:55,845 --> 04:01:57,647
SO ON THE NEXT SLIDE I WANT TO 

6167
04:01:57,647 --> 04:01:59,749
SAY THIS PART OF THING IS GOING 

6168
04:01:59,749 --> 04:02:02,152
TO LEAD TO THREE MAJOR PARADIGM 

6169
04:02:02,152 --> 04:02:04,988
CHANGES IN DATA-DRIVEN HEALTH.

6170
04:02:04,988 --> 04:02:07,490
ONE ON THE NEXT CLICK THE IDEA 

6171
04:02:07,490 --> 04:02:09,959
WE WILL REPLACE DISEASE ORIENTED

6172
04:02:09,959 --> 04:02:14,831
WITH WELLNESS AND PREVENTION AND

6173
04:02:14,831 --> 04:02:17,067
ULTIMATELY AN N OF 1 MEDICINE 

6174
04:02:17,067 --> 04:02:20,637
WITH TENS OF THOUSANDS OF 

6175
04:02:20,637 --> 04:02:21,271
ACTIONABLE POSSIBILITIES.

6176
04:02:21,271 --> 04:02:23,740
NUMBER TWO, NEXT CLICK, WILL 

6177
04:02:23,740 --> 04:02:26,810
LEAD TO DEMOCRATIZATION OF 

6178
04:02:26,810 --> 04:02:29,712
HEALTH CARE BRINGING IT INTO THE

6179
04:02:29,712 --> 04:02:31,081
HOME MEDIATED BY THE CELL PHONE 

6180
04:02:31,081 --> 04:02:32,549
AND AVAILABLE FOR UNDERDEVELOPED

6181
04:02:32,549 --> 04:02:34,918
COUNTRIES AND NUMBER THREE, AI 

6182
04:02:34,918 --> 04:02:37,854
IS GOING TO BE TRANSFORMATIONAL.

6183
04:02:37,854 --> 04:02:40,156
THE PARTNERSHIP BETWEEN AI AND 

6184
04:02:40,156 --> 04:02:41,925
PHYSICIANS WILL CREATE 

6185
04:02:41,925 --> 04:02:45,495
SUPERPHYSICIANS THAT WILL HAVE 

6186
04:02:45,495 --> 04:02:47,230
THE ABLE TO TREAT PATIENTS IN 

6187
04:02:47,230 --> 04:02:52,035
WAY PHYSICIANS COULD NEVER DO SO

6188
04:02:52,035 --> 04:02:52,936
BEFORE.

6189
04:02:52,936 --> 04:02:56,172
SO ON THE NEXT SLIDE, SO LET ME 

6190
04:02:56,172 --> 04:03:01,277
ASK, THIS FINISHES THE DATA-

6191
04:03:01,277 --> 04:03:04,948
DATA-DRIN -- DATA-DRIVEN THING.

6192
04:03:04,948 --> 04:03:06,916
IS THERE ENOUGH TIME TO GO 

6193
04:03:06,916 --> 04:03:09,185
THROUGH FIVE OR SIX SLIDES ON 

6194
04:03:09,185 --> 04:03:10,487
THIS NEW DRUG TARGET.

6195
04:03:10,487 --> 04:03:12,522
>> I THINK PEOPLE WOULD
LOVE TO 

6196
04:03:12,522 --> 04:03:14,023
HAVE TIME TO ASK YOU A FEW 

6197
04:03:14,023 --> 04:03:14,290
QUESTIONS.

6198
04:03:14,290 --> 04:03:16,226
THAT IS MY OPINION.

6199
04:03:16,226 --> 04:03:16,860
>> OKAY.

6200
04:03:16,860 --> 04:03:19,462
SO WHY DON'T WE SKIP THE DRUG 

6201
04:03:19,462 --> 04:03:19,662
PART.

6202
04:03:19,662 --> 04:03:21,898
JUST SAY -- I'LL JUST TELL YOU I

6203
04:03:21,898 --> 04:03:24,734
THINK IN 10 YEARS THIS NEW 

6204
04:03:24,734 --> 04:03:27,537
APPROACH IS GOING TO 

6205
04:03:27,537 --> 04:03:28,972
REVOLUTIONIZE HOW WE CREATE 

6206
04:03:28,972 --> 04:03:31,307
DRUGS WITH REGARD TO SPEED, 

6207
04:03:31,307 --> 04:03:38,848
COST, EFFICIENCY AND O

6208
04:03:38,848 --> 04:03:39,182
OPTIMIIZATION.

6209
04:03:39,182 --> 04:03:44,020
MY TEAM HAS BEEN FANTASTIC.

6210
04:03:44,020 --> 04:03:45,788
PHENOME HEALTH IS SMALL AND WE 

6211
04:03:45,788 --> 04:03:48,124
HAVE DONE AN ENORMOUS AMOUNT.

6212
04:03:48,124 --> 04:03:48,992
ON THE LAST SLIDE IS THE TEAM 

6213
04:03:48,992 --> 04:03:55,231
THAT HAS SUPPORTED US THE BOARD 

6214
04:03:55,231 --> 04:03:57,567
IS THREE OF THE MOST OUTSTANDING

6215
04:03:57,567 --> 04:03:58,635
PEOPLE I HAVE DEALT WITH IN 

6216
04:03:58,635 --> 04:03:59,435
RECENT TIMES.

6217
04:03:59,435 --> 04:04:03,473
CAN WE HAVE THE NEXT SLIDE, 

6218
04:04:03,473 --> 04:04:03,706
PLEASE.

6219
04:04:03,706 --> 04:04:06,910
JEFF WILKE WAS NUMBER TWO AT 

6220
04:04:06,910 --> 04:04:09,179
AMAZON FOR THE EARLY YEARS.

6221
04:04:09,179 --> 04:04:13,483
ROGER -- WAS NUMBER TWO AT AMGEN

6222
04:04:13,483 --> 04:04:15,218
AND MERCK.

6223
04:04:15,218 --> 04:04:18,688
AND IS REALLY PIONEERING SOME 

6224
04:04:18,688 --> 04:04:23,359
STRIKING NEW APPROACHED IN DRUG 

6225
04:04:23,359 --> 04:04:24,160
DISCOVERY NOW.

6226
04:04:24,160 --> 04:04:29,465
AND MARIA KLAWE WAS 17 YEARS AT 

6227
04:04:29,465 --> 04:04:32,335
HARVEY MUD PRESIDENT DATA 

6228
04:04:32,335 --> 04:04:32,835
SCIENCE.

6229
04:04:32,835 --> 04:04:35,939
AND GEORGE CHURCH AND GILL OMENN

6230
04:04:35,939 --> 04:04:40,276
AND RALPH SNYDERMAN HAVE BEEN 

6231
04:04:40,276 --> 04:04:42,712
TREMENDOUS CONTRIBUTORS AS 

6232
04:04:42,712 --> 04:04:47,517
MICHELLE WILLIAMS AND LARRY 

6233
04:04:47,517 --> 04:04:47,717
SMARR.

6234
04:04:47,717 --> 04:04:55,959
SO WITH THAT, I AM GLAD TO TAKE 

6235
04:04:55,959 --> 04:04:56,226
QUESTIONS.

6236
04:04:56,226 --> 04:04:57,627
I SUGGEST YOU SWITCH TO ZOOM FOR

6237
04:04:57,627 --> 04:05:05,702
OUTSIDE PEOPLE.

6238
04:05:05,702 --> 04:05:07,637
THIS IS IMPOSSIBLE TO GIVE A 

6239
04:05:07,637 --> 04:05:10,206
LECTURE WITH DELAYS LIKE THIS 

6240
04:05:10,206 --> 04:05:12,375
AND FEEL COMFORTABLE ABOUT IT.

6241
04:05:12,375 --> 04:05:12,609
ANYWAY.

6242
04:05:12,609 --> 04:05:14,477
>> YOU DID A FANTASTIC JOB

6243
04:05:14,477 --> 04:05:16,913
GIVING A LECTURE.

6244
04:05:16,913 --> 04:05:18,848
AND I APOLOGIZE FOR ALL THE 

6245
04:05:18,848 --> 04:05:19,916
TECHNICAL.

6246
04:05:19,916 --> 04:05:21,584
>> IT IS NOT YOUR FAULT.

6247
04:05:21,584 --> 04:05:24,320
IT IS MICROSOFT'S.

6248
04:05:24,320 --> 04:05:33,997
>> AND WE KNOW THAT.

6249
04:05:33,997 --> 04:05:37,867
I'M GOING TO LEAD OFF WITH SOME 

6250
04:05:37,867 --> 04:05:40,637
QUICK QUESTIONS.

6251
04:05:40,637 --> 04:05:42,572
COUNCIL MEMBERS, LET'S TAKE TIME

6252
04:05:42,572 --> 04:05:44,941
TO ASK LEE A FEW QUESTIONS AND 

6253
04:05:44,941 --> 04:05:46,609
MOVE ON TO GENERAL DISCUSSION IN

6254
04:05:46,609 --> 04:05:47,443
THE AFTERNOON.

6255
04:05:47,443 --> 04:05:50,413
LEE, WHAT YOU OUTLINED FROM MY 

6256
04:05:50,413 --> 04:05:53,349
PERSPECTIVE IS FABULOUS.

6257
04:05:53,349 --> 04:05:55,518
WHAT ABOUT THE CHALLENGES 

6258
04:05:55,518 --> 04:05:56,319
ASSOCIATED WITH MENTAL HEALTH.

6259
04:05:56,319 --> 04:05:59,055
THIS IS A NORA QUESTION, 

6260
04:05:59,055 --> 04:06:01,491
REPOSITORIES OF IMAGING DATA.

6261
04:06:01,491 --> 04:06:03,793
WILL THEY BE HELPFUL OR A 

6262
04:06:03,793 --> 04:06:04,060
HINDRANCE?

6263
04:06:04,060 --> 04:06:06,162
>> I DIDN'T TALK ABOUT
BRAIN 

6264
04:06:06,162 --> 04:06:08,064
HEALTH AND IT IS REALLY 

6265
04:06:08,064 --> 04:06:08,331
IMPORTANT.

6266
04:06:08,331 --> 04:06:11,768
I THINK EVERYTHING WE CAN DO AND

6267
04:06:11,768 --> 04:06:14,337
SO WE THINK IMAGING IS GOING TO 

6268
04:06:14,337 --> 04:06:16,606
BE IMPORTANT.

6269
04:06:16,606 --> 04:06:22,912
FOR EXAMPLE, I THINK RETINAL 

6270
04:06:22,912 --> 04:06:24,747
ANALYSES ARE IMPORTANT IN BRAIN 

6271
04:06:24,747 --> 04:06:24,981
HEALTH.

6272
04:06:24,981 --> 04:06:26,482
THEY GIVE YOU A CHANCE TO LOOK 

6273
04:06:26,482 --> 04:06:27,817
AT THE VASCULAR SYSTEM THERE AND

6274
04:06:27,817 --> 04:06:29,152
SO FORTH.

6275
04:06:29,152 --> 04:06:32,722
I THINK COGNITIVE ABILITIES ARE 

6276
04:06:32,722 --> 04:06:36,926
ABSOLUTELY CRITICAL AND MY GOOD 

6277
04:06:36,926 --> 04:06:43,099
FRIEND MICHAEL MURZINSKY HAS 

6278
04:06:43,099 --> 04:06:45,034
INVENTED THIS BRAIN ANALYSIS 

6279
04:06:45,034 --> 04:06:48,237
SYSTEM CALLED BRAIN HQ WHICH HAS

6280
04:06:48,237 --> 04:06:50,640
THE ABILITY IN A COMPUTERIZED 

6281
04:06:50,640 --> 04:06:53,476
GAME KIND OF FASHION TO ASSESS 

6282
04:06:53,476 --> 04:06:56,312
25 DIFFERENT FEATURES OF 

6283
04:06:56,312 --> 04:06:57,647
COGNITIVE HEALTH AND WHERE THEY 

6284
04:06:57,647 --> 04:07:00,683
FIND DEFICIENCIES BECAUSE OF THE

6285
04:07:00,683 --> 04:07:03,653
PLASTICITY OF THE BRAIN, IF YOU 

6286
04:07:03,653 --> 04:07:09,192
HAVE NOT LOST A LOT OF NEURONS, 

6287
04:07:09,192 --> 04:07:10,893
YOU CAN FILL IN DEFICIENT 

6288
04:07:10,893 --> 04:07:11,928
REACTION FEATURES SUCH AS 

6289
04:07:11,928 --> 04:07:14,597
REACTION TIME OR MEMORY OR DEPTH

6290
04:07:14,597 --> 04:07:16,899
OF FIELD OR ALL OF THESE KINDS 

6291
04:07:16,899 --> 04:07:17,567
OF THINGS.

6292
04:07:17,567 --> 04:07:19,902
WHAT MICHAEL SHOWED IS A NORMAL 

6293
04:07:19,902 --> 04:07:22,872
INDIVIDUAL GOES TO A COGNITIVE 

6294
04:07:22,872 --> 04:07:27,844
MAXIMUM IN EARLY 30s AND FADES 

6295
04:07:27,844 --> 04:07:28,411
AWAY THEREAFTER.

6296
04:07:28,411 --> 04:07:30,680
EVEN INTELLECTUALLY ACTIVE 

6297
04:07:30,680 --> 04:07:32,949
PEOPLE DON'T GET THE RIGHT KIND 

6298
04:07:32,949 --> 04:07:35,551
OF EXERCISES FOR MANY COGNITIVE 

6299
04:07:35,551 --> 04:07:35,818
FEATURES.

6300
04:07:35,818 --> 04:07:38,020
WHAT HE DEMONSTRATED IS FOR A 

6301
04:07:38,020 --> 04:07:40,156
LARGE NUMBER OF 80-YEAR-OLDS, HE

6302
04:07:40,156 --> 04:07:41,557
COULD BRING THEM BACK TO WHERE 

6303
04:07:41,557 --> 04:07:43,459
THEY WERE BEFORE.

6304
04:07:43,459 --> 04:07:46,362
SO I THINK BRAIN HQ IS 

6305
04:07:46,362 --> 04:07:48,364
ABSOLUTELY AN ESSENTIAL PART OF 

6306
04:07:48,364 --> 04:07:52,802
THE THING AND THE ONE LEADING 

6307
04:07:52,802 --> 04:07:53,603
FEATURE IS REACTION TIME.

6308
04:07:53,603 --> 04:07:57,273
EVERYTHING FOLLOWS THE COGNITIVE

6309
04:07:57,273 --> 04:08:00,543
ABILITY OF REACTION TIME IN A 

6310
04:08:00,543 --> 04:08:02,412
LEMUR LIKE HERD FASHION AND 

6311
04:08:02,412 --> 04:08:02,745
EVERYTHING.

6312
04:08:02,745 --> 04:08:04,547
I THINK ANOTHER THING THAT WE 

6313
04:08:04,547 --> 04:08:10,920
ARE LOOKING AT IS EEG KIND OF 

6314
04:08:10,920 --> 04:08:14,323
ANALYSES AND AGAIN, MICHAEL M 

6315
04:08:14,323 --> 04:08:17,059
THINKS THERE ARE SOME REALLY 

6316
04:08:17,059 --> 04:08:17,727
FASCINATING POSSIBILITIES WITH 

6317
04:08:17,727 --> 04:08:20,997
THE BRAIN HG AND EEG BEING ABLE 

6318
04:08:20,997 --> 04:08:23,399
TO MAKE VERY EARLY PREDICTIONS 

6319
04:08:23,399 --> 04:08:26,903
ON TRANSITIONS TOWARD DEPRESSION

6320
04:08:26,903 --> 04:08:30,072
OR TRANSITIONS TOWARD 

6321
04:08:30,072 --> 04:08:31,340
SCHIZOPHRENIA OR BIPOLAR DISEASE

6322
04:08:31,340 --> 04:08:33,910
AND HE'S GOT A LOT OF CLINICAL 

6323
04:08:33,910 --> 04:08:37,113
TRIALS DEMONSTRATING ALL THESE 

6324
04:08:37,113 --> 04:08:37,613
POSSIBILITIES.

6325
04:08:37,613 --> 04:08:40,817
THE BRAIN IMAGING CERTAINLY 

6326
04:08:40,817 --> 04:08:42,084
GIVES US A DIRECT MEASURE OF THE

6327
04:08:42,084 --> 04:08:43,886
CHANGE IN CONTENT AND STRUCTURE 

6328
04:08:43,886 --> 04:08:45,154
OF THE BRAIN.

6329
04:08:45,154 --> 04:08:48,424
AND THAT IS GOING TO BE AN 

6330
04:08:48,424 --> 04:08:50,326
ABSOLUTELY CRITICAL CORRELATIVE 

6331
04:08:50,326 --> 04:08:51,294
KIND OF THING.

6332
04:08:51,294 --> 04:08:53,162
BUT IT IS REALLY IMPORTANT TO 

6333
04:08:53,162 --> 04:08:55,531
PUT THE PHYSICAL FEATURES 

6334
04:08:55,531 --> 04:08:59,869
TOGETHER WITH THE OMIC FEATURES.

6335
04:08:59,869 --> 04:09:02,305
TOGETHER WITH ALL THE DATA 

6336
04:09:02,305 --> 04:09:04,307
INTEGRATION MOVE YOU WAY BEYOND 

6337
04:09:04,307 --> 04:09:10,913
WHAT ANY TYPE OF DATA ALONE CAN 

6338
04:09:10,913 --> 04:09:12,448
TELL US.

6339
04:09:12,448 --> 04:09:14,917
>> IF REACTION TIME IS SO 

6340
04:09:14,917 --> 04:09:16,219
IMPORTANT, YOU BEST NOT DRINK 

6341
04:09:16,219 --> 04:09:18,187
ALCOHOL OVER 80.

6342
04:09:18,187 --> 04:09:19,722
NORA, YOU HAVE A QUESTION.

6343
04:09:19,722 --> 04:09:21,557
>> YES, YES.

6344
04:09:21,557 --> 04:09:22,792
LEE, THAT WAS FANTASTIC.

6345
04:09:22,792 --> 04:09:24,360
THERE IS NO DOUBT, YOU ARE 

6346
04:09:24,360 --> 04:09:26,429
ABSOLUTELY RIGHT AND I THINK YOU

6347
04:09:26,429 --> 04:09:28,297
ARE VISIONARY ON THIS NOTION OF 

6348
04:09:28,297 --> 04:09:29,198
HOW CRUCIAL IT IS.

6349
04:09:29,198 --> 04:09:30,900
AND IMPORTANTLY WE CAN GET 

6350
04:09:30,900 --> 04:09:31,100
THERE.

6351
04:09:31,100 --> 04:09:32,468
THERE ARE MANY, MANY PROJECTS 

6352
04:09:32,468 --> 04:09:34,670
GOING ON AT THE NIH TO TRY TO 

6353
04:09:34,670 --> 04:09:36,739
ACHIEVE IT.

6354
04:09:36,739 --> 04:09:38,007
OBVIOUSLY, THE KEY ONE IS -- ONE

6355
04:09:38,007 --> 04:09:41,577
OF THE KEY ONES IS THE -- FOR US

6356
04:09:41,577 --> 04:09:43,746
AT THE NIH, HOW DO WE TAKE 

6357
04:09:43,746 --> 04:09:45,281
ADVANTAGE OF ALL OF THE 

6358
04:09:45,281 --> 04:09:47,550
DIFFERENT INITIATIVES THAT ARE 

6359
04:09:47,550 --> 04:09:48,985
ONGOING TRYING TO DO WHAT YOU 

6360
04:09:48,985 --> 04:09:51,287
PRESENTED TO DO IN SUCH A 

6361
04:09:51,287 --> 04:09:52,955
COMPREHENSIVE FASHION?

6362
04:09:52,955 --> 04:09:55,925
SO THAT WE DON'T DO -- THAT WE 

6363
04:09:55,925 --> 04:09:57,927
MAXIMIZE THESE DATA THAT IS 

6364
04:09:57,927 --> 04:10:00,963
MERGING, THAT WE GENERATE 

6365
04:10:00,963 --> 04:10:02,231
COMPARISONS BETWEEN ONE AND THE 

6366
04:10:02,231 --> 04:10:02,431
OTHER.

6367
04:10:02,431 --> 04:10:03,332
QUESTION NUMBER ONE.

6368
04:10:03,332 --> 04:10:05,701
AND I CAN STOP THERE.

6369
04:10:05,701 --> 04:10:07,803
BUT MY QUESTION NUMBER TWO WHICH

6370
04:10:07,803 --> 04:10:09,305
IMMEDIATELY MADE ME VERY EXCITED

6371
04:10:09,305 --> 04:10:10,640
BECAUSE YOU HAD SOME BEAUTIFUL 

6372
04:10:10,640 --> 04:10:12,808
EXAMPLES, YOU ARE LOOKING AT ALL

6373
04:10:12,808 --> 04:10:16,612
OF THESE PARAMETERS AND 

6374
04:10:16,612 --> 04:10:18,781
PROTEOMICS AND WE CAN LOOK AND 

6375
04:10:18,781 --> 04:10:20,216
TRACK WHO MAY RESPOND OR NOT.

6376
04:10:20,216 --> 04:10:23,452
NOW WE ARE EXCITED WITH 

6377
04:10:23,452 --> 04:10:26,055
ANTI-INFLAMMATORY DRUGS 

6378
04:10:26,055 --> 04:10:26,889
TARGETING METABOLISM, LIB 

6379
04:10:26,889 --> 04:10:27,723
PEPTIDE DRUGS.

6380
04:10:27,723 --> 04:10:29,358
HOW DO WE MONITOR THE CHANGES 

6381
04:10:29,358 --> 04:10:31,193
THAT THESE DRUGS ARE DOING IN 

6382
04:10:31,193 --> 04:10:32,995
ALL OF THESE PARAMETERS?

6383
04:10:32,995 --> 04:10:34,897
HAVE YOU, IN YOUR PROPOSAL YOU 

6384
04:10:34,897 --> 04:10:37,066
HAVE FOR DIABETES, IS THIS ONE 

6385
04:10:37,066 --> 04:10:38,167
OF THE THINGS YOU ARE GOING TO 

6386
04:10:38,167 --> 04:10:39,268
BE LOOKING AT?

6387
04:10:39,268 --> 04:10:41,170
>> ABSOLUTELY.

6388
04:10:41,170 --> 04:10:43,139
SO I MEAN YOU ASKED ME ABOUT 

6389
04:10:43,139 --> 04:10:44,273
FOUR DIFFERENT QUESTIONS THERE.

6390
04:10:44,273 --> 04:10:45,274
>> TWO.

6391
04:10:45,274 --> 04:10:45,908
TWO.

6392
04:10:45,908 --> 04:10:47,109
>> OKAY.

6393
04:10:47,109 --> 04:10:50,746
I WOULD SAY ONE, I HAVE TAKEN 

6394
04:10:50,746 --> 04:10:53,215
THE INITIATIVE, THE HUMAN 

6395
04:10:53,215 --> 04:10:55,785
PHENOME INITIATIVE AND RELABELED

6396
04:10:55,785 --> 04:11:01,824
IT MAKE AMERICA HEALTHY, BUT I 

6397
04:11:01,824 --> 04:11:03,092
DID NOT PUT AGAIN ON IT.

6398
04:11:03,092 --> 04:11:05,561
WE HAVE PRESENTED IT WITH A KEY 

6399
04:11:05,561 --> 04:11:08,898
LOBBYIST I HAVE HERE TO THE 

6400
04:11:08,898 --> 04:11:10,399
TRUMP TRANSITION TEAM AND IT'S 

6401
04:11:10,399 --> 04:11:13,836
ACTUALLY RECEIVED A LOT OF 

6402
04:11:13,836 --> 04:11:15,938
ENTHUSIASM ENDORSEMENT.

6403
04:11:15,938 --> 04:11:17,306
AND, OF COURSE, WHAT I'VE TALKED

6404
04:11:17,306 --> 04:11:19,709
ABOUT HERE, THE MAJOR FOCUS HAS 

6405
04:11:19,709 --> 04:11:24,280
BEEN ON THE PHENOMICS WHICH ONLY

6406
04:11:24,280 --> 04:11:26,882
RECENTLY ALL OF US GOT AROUND TO

6407
04:11:26,882 --> 04:11:30,453
DOING.

6408
04:11:30,453 --> 04:11:32,154
I ARGUED WITH THEM AT THE 

6409
04:11:32,154 --> 04:11:34,156
BEGINNING, YOU SHOULD TAKE A 

6410
04:11:34,156 --> 04:11:36,258
SMALLER NUMBER AND DO PHENOMICS 

6411
04:11:36,258 --> 04:11:39,395
AND END UP FAR AHEAD, BUT I GOT 

6412
04:11:39,395 --> 04:11:39,629
NOWHERE.

6413
04:11:39,629 --> 04:11:42,331
BUT ANYWAY, WHAT I WOULD SAY IS 

6414
04:11:42,331 --> 04:11:44,500
LET'S ALL GO TOGETHER AND TRY 

6415
04:11:44,500 --> 04:11:48,270
AND CONVINCE TRUMP TO DO A 

6416
04:11:48,270 --> 04:11:50,106
PHENOMIC INITIATIVE NOW THAT 

6417
04:11:50,106 --> 04:11:52,274
EXTENDS OUT FROM THE ORIGINAL 

6418
04:11:52,274 --> 04:11:54,944
GENOME THING AND, YOU KNOW, THE 

6419
04:11:54,944 --> 04:11:57,680
REALLY IMPORTANT THING THAT THIS

6420
04:11:57,680 --> 04:12:03,386
THING DOES IS BY BRINGING VOLUME

6421
04:12:03,386 --> 04:12:06,889
WILL BOTH DEVELOP NEW 

6422
04:12:06,889 --> 04:12:08,090
TECHNOLOGIES AND BRING THE COST 

6423
04:12:08,090 --> 04:12:10,693
DOWN STRIKINGLY.

6424
04:12:10,693 --> 04:12:14,130
THE FIRST HUMAN GENOME PROJECT 

6425
04:12:14,130 --> 04:12:16,632
WE DID THAT SEVEN ORDERS OF 

6426
04:12:16,632 --> 04:12:18,067
MAGNITUDE OF WHAT THE FIRST 

6427
04:12:18,067 --> 04:12:18,401
GENOME COST.

6428
04:12:18,401 --> 04:12:20,236
WE ARE GOING TO DO THE SAME WITH

6429
04:12:20,236 --> 04:12:22,738
THE PHENOME IF WE CAN GET THIS 

6430
04:12:22,738 --> 04:12:23,005
GOING.

6431
04:12:23,005 --> 04:12:26,909
I WOULD LOVE TO COME TO NIH AND 

6432
04:12:26,909 --> 04:12:33,516
CENTRAL -- STRATEGIZE.

6433
04:12:33,516 --> 04:12:35,451
I CAN TELL YOU WHAT WE HAVE DONE

6434
04:12:35,451 --> 04:12:36,585
AND HOW WE HAVE DONE IT.

6435
04:12:36,585 --> 04:12:40,690
WE ARE FOCUSED ON ARPAH BECAUSE 

6436
04:12:40,690 --> 04:12:43,025
IT IS MORE FLEXIBLE FOR LARGE 

6437
04:12:43,025 --> 04:12:44,593
PROJECTS THAN NIH WAS.

6438
04:12:44,593 --> 04:12:46,362
I MEAN, NIH'S ATTITUDE WHEN I 

6439
04:12:46,362 --> 04:12:48,297
WENT AND TRIED TO GET SUPPORT IS

6440
04:12:48,297 --> 04:12:50,466
WE ARE DOING ALL OF THIS 

6441
04:12:50,466 --> 04:12:50,700
ALREADY.

6442
04:12:50,700 --> 04:12:53,235
AND I THINK WHAT ALL OF US DID 

6443
04:12:53,235 --> 04:12:56,505
IS GREAT, BUT IT IS NOT 

6444
04:12:56,505 --> 04:12:56,806
PHENOMICS.

6445
04:12:56,806 --> 04:12:57,373
OKAY.

6446
04:12:57,373 --> 04:12:58,074
SO ANYWAY.

6447
04:12:58,074 --> 04:13:00,209
I WOULD LOVE TO GET TOGETHER.

6448
04:13:00,209 --> 04:13:04,914
I THINK WE COULD BUILD A 

6449
04:13:04,914 --> 04:13:06,515
FEDERATED SERIES OF PLATFORMS, 

6450
04:13:06,515 --> 04:13:07,783
WHICH IS WHAT WE ARE GOING TO DO

6451
04:13:07,783 --> 04:13:10,686
IN THE EU.

6452
04:13:10,686 --> 04:13:19,995
WE HAVE LUXEMBORG INTERESTED, 

6453
04:13:19,995 --> 04:13:20,930
ASTONIA AND TURKEY.

6454
04:13:20,930 --> 04:13:22,331
MAYBE THE UK.

6455
04:13:22,331 --> 04:13:23,566
THEY HAVE FINANCIAL PROBLEMS 

6456
04:13:23,566 --> 04:13:25,267
WITH THE NATIONAL HEALTH SYSTEM 

6457
04:13:25,267 --> 04:13:28,437
THAT MAY NOT PREVENT THIS.

6458
04:13:28,437 --> 04:13:30,906
I MEAN, PHENOMICS IS GOING AHEAD

6459
04:13:30,906 --> 04:13:33,309
ON A BIG SCALE IN OTHER PLACES 

6460
04:13:33,309 --> 04:13:37,413
AND THAT IS ONE OF THE 

6461
04:13:37,413 --> 04:13:38,347
COMPELLING ARGUMENTS WE HAVE FOR

6462
04:13:38,347 --> 04:13:38,681
CONGRESS NOW.

6463
04:13:38,681 --> 04:13:40,850
UH AND IT IS GOING AHEAD IN 

6464
04:13:40,850 --> 04:13:41,717
CHINA IN SPADES.

6465
04:13:41,717 --> 04:13:42,752
I'LL TELL YOU.

6466
04:13:42,752 --> 04:13:47,156
SO WE HAVE TO GET WITH IT.

6467
04:13:47,156 --> 04:13:48,991
AND IF WE DID IT TOGETHER, THAT 

6468
04:13:48,991 --> 04:13:51,227
COULD BE AN INCREDIBLE 

6469
04:13:51,227 --> 04:13:51,527
PARTNERSHIP.

6470
04:13:51,527 --> 04:13:54,163
WHY DON'T YOU FIGURE THAT OUT 

6471
04:13:54,163 --> 04:13:55,831
AND I WILL COME ANY TIME YOU 

6472
04:13:55,831 --> 04:13:57,466
WANT TO TALK ABOUT WHAT WE'VE 

6473
04:13:57,466 --> 04:13:59,702
DONE AND HOW WE PROPOSE TO DO 

6474
04:13:59,702 --> 04:13:59,869
IT.

6475
04:13:59,869 --> 04:14:01,804
WE ARE DOING A LOT OF THE SAME 

6476
04:14:01,804 --> 04:14:03,005
KIND OF THINGS YOU HAVE.

6477
04:14:03,005 --> 04:14:05,574
WE HAVE A COMPUTATIONAL PLATFORM

6478
04:14:05,574 --> 04:14:10,446
THAT IS ABSOLUTELY SUPERB FOR 

6479
04:14:10,446 --> 04:14:12,615
MULTIOMIC ANALYSIS, COMPATIBLE 

6480
04:14:12,615 --> 04:14:14,350
WITH ALL THESE CLOUDS.

6481
04:14:14,350 --> 04:14:17,119
PERFECT FOR FEDERATED KINDS OF 

6482
04:14:17,119 --> 04:14:18,354
DATA SYSTEMS WHERE X WANTS TO 

6483
04:14:18,354 --> 04:14:20,556
KEEP THE DATA TO THEMSELVES, BUT

6484
04:14:20,556 --> 04:14:22,892
THEY WILL LET YOU BRING THE 

6485
04:14:22,892 --> 04:14:24,360
ANALYTIC TOOLS TO THEM AND TAKE 

6486
04:14:24,360 --> 04:14:26,729
THE META DATA AWAY WITH 

6487
04:14:26,729 --> 04:14:28,631
APPROPRIATE IP AGREEMENTS AND 

6488
04:14:28,631 --> 04:14:29,832
ALL THE OTHER KIND OF THING.

6489
04:14:29,832 --> 04:14:32,601
THAT IS WHAT WE ARE DOING IN THE

6490
04:14:32,601 --> 04:14:34,904
EU AND WITH TURKEY AND IT IS 

6491
04:14:34,904 --> 04:14:35,371
WORKING BEAUTIFULLY.

6492
04:14:35,371 --> 04:14:36,172
>> THANKS.

6493
04:14:36,172 --> 04:14:38,007
I WILL REACH OUT TO YOU.

6494
04:14:38,007 --> 04:14:41,510
I DON'T WANT TO TAKE ANY MORE 

6495
04:14:41,510 --> 04:14:41,710
TIME.

6496
04:14:41,710 --> 04:14:43,913
>> I WOULD LOVE TO PARTNER
WITH 

6497
04:14:43,913 --> 04:14:46,215
NIH ON THIS THING IN ANY WAY WE 

6498
04:14:46,215 --> 04:14:48,818
COULD THAT WOULD BE USEFUL.

6499
04:14:48,818 --> 04:14:50,653
>> THANKS VERY MUCH.

6500
04:14:50,653 --> 04:14:56,592
I TURN IT BACK TO YOU, GEORGE.

6501
04:14:56,592 --> 04:14:59,361
>> COUNT US IN AT THE
ALCOHOL 

6502
04:14:59,361 --> 04:15:01,063
INSTITUTE AS WELL.

6503
04:15:01,063 --> 04:15:07,436
I REALLY AGREE WITH NORA.

6504
04:15:07,436 --> 04:15:10,339
THERE'S SO MUCH WE COULD ALL DO 

6505
04:15:10,339 --> 04:15:12,308
TOGETHER AND WHETHER WE COULD 

6506
04:15:12,308 --> 04:15:14,043
EFFECT IT UNDER THE CURRENT 

6507
04:15:14,043 --> 04:15:15,344
CLIMATE IS THE CHALLENGE.

6508
04:15:15,344 --> 04:15:16,312
>> WHEN WE CAN.

6509
04:15:16,312 --> 04:15:18,314
I THINK WE HAVE TO HAVE 

6510
04:15:18,314 --> 04:15:19,849
DETERMINED OPTIMISM AND MOVE 

6511
04:15:19,849 --> 04:15:22,885
AHEAD AND, LOOK, IF WE CAN'T GET

6512
04:15:22,885 --> 04:15:24,854
IT INITIALLY WITH THE -- FROM 

6513
04:15:24,854 --> 04:15:26,021
THE FEDERAL GOVERNMENT, WE'LL --

6514
04:15:26,021 --> 04:15:33,562
I THINK WE CAN GET IT FROM 

6515
04:15:33,562 --> 04:15:33,896
PHILANTHROPY.

6516
04:15:33,896 --> 04:15:36,565
WE HAVE TO WORK TOGETHER IN A 

6517
04:15:36,565 --> 04:15:37,900
COORDINATED WAY TO MAKE A PITCH 

6518
04:15:37,900 --> 04:15:38,901
TO THE BILL GATES TO GIVE THE 

6519
04:15:38,901 --> 04:15:39,835
MONEY AWAY.

6520
04:15:39,835 --> 04:15:41,804
THAT IS ONE PLACE WE COULD GO 

6521
04:15:41,804 --> 04:15:47,910
THAT WOULD BE VERY INTERESTING.

6522
04:15:47,910 --> 04:15:50,112
>> SO COUNCILMEMBERS, WE
HAVE 

6523
04:15:50,112 --> 04:15:52,715
HOGGED THE MICROPHONE, NORA AND 

6524
04:15:52,715 --> 04:15:54,283
I WITH OUR QUESTIONS.

6525
04:15:54,283 --> 04:15:56,318
DO YOU ALL HAVE ANY QUESTIONS 

6526
04:15:56,318 --> 04:15:57,152
FOR LEE?

6527
04:15:57,152 --> 04:15:57,386
PLEASE.

6528
04:15:57,386 --> 04:15:59,355
THIS IS AN OPPORTUNITY TO ASK IF

6529
04:15:59,355 --> 04:16:05,661
YOU HAVE ANY QUESTIONS.

6530
04:16:05,661 --> 04:16:05,861
KATE.

6531
04:16:05,861 --> 04:16:06,896
>> THANK YOU.

6532
04:16:06,896 --> 04:16:09,131
LEE, THANK YOU FOR SUCH A 

6533
04:16:09,131 --> 04:16:09,832
PHENOMENAL PRESENTATION.

6534
04:16:09,832 --> 04:16:12,534
MY BRAIN IS JUST SPINNING TRYING

6535
04:16:12,534 --> 04:16:14,536
TO SYNTHESIZE EVERYTHING, BUT I 

6536
04:16:14,536 --> 04:16:16,305
HAD A SPECIFIC QUESTION 

6537
04:16:16,305 --> 04:16:18,274
FOLLOWING ON WHAT NORA WAS 

6538
04:16:18,274 --> 04:16:19,208
ASKING ABOUT.

6539
04:16:19,208 --> 04:16:25,281
AND IT HAS TO DO WITH THE AI 

6540
04:16:25,281 --> 04:16:26,715
CHATBOT FOR PATIENTS AND WHETHER

6541
04:16:26,715 --> 04:16:29,051
OR NOT YOU ARE EXPLORING THAT AS

6542
04:16:29,051 --> 04:16:30,653
A POTENTIAL INTERVENTIONAL TOOL 

6543
04:16:30,653 --> 04:16:33,322
FOR FILL IN THE BLANK DISEASE 

6544
04:16:33,322 --> 04:16:33,555
STATES?

6545
04:16:33,555 --> 04:16:35,457
I'M INTERESTED IN HOW IT MIGHT 

6546
04:16:35,457 --> 04:16:38,494
BE APPLICABLE TO TREATMENTS FOR 

6547
04:16:38,494 --> 04:16:39,995
SUBSTANCE USE DISORDERS.

6548
04:16:39,995 --> 04:16:40,829
THANK YOU.

6549
04:16:40,829 --> 04:16:41,497
>> ABSOLUTELY.

6550
04:16:41,497 --> 04:16:43,866
WE CAN FOCUS ANY WAY YOU WANT TO

6551
04:16:43,866 --> 04:16:44,066
FOCUS.

6552
04:16:44,066 --> 04:16:46,135
IT IS ALL A MATTER OF HOW YOU 

6553
04:16:46,135 --> 04:16:47,970
TRAIN THE AI.

6554
04:16:47,970 --> 04:16:50,039
ACTUALLY, WHAT WE DID IS WE HAVE

6555
04:16:50,039 --> 04:16:52,074
A LOT OF GENERAL EDUCATIONAL 

6556
04:16:52,074 --> 04:16:52,441
MATERIAL.

6557
04:16:52,441 --> 04:16:54,777
I WROTE A BOOK WITH NATHAN PRICE

6558
04:16:54,777 --> 04:16:57,346
ON THIS WHOLE IDEA.

6559
04:16:57,346 --> 04:16:58,681
WE PUT THAT IN.

6560
04:16:58,681 --> 04:17:02,484
WE WROTE A REVIEW IN NATURE 

6561
04:17:02,484 --> 04:17:05,187
REVIEWS OF OMICS AND THE 

6562
04:17:05,187 --> 04:17:05,487
REVOLUTION.

6563
04:17:05,487 --> 04:17:07,356
WE PUT THAT IN.

6564
04:17:07,356 --> 04:17:10,125
WE HAVE TWO SUB ISSUES OF 

6565
04:17:10,125 --> 04:17:12,094
SCIENTIFIC AMERICAN, ONE ON THE 

6566
04:17:12,094 --> 04:17:16,565
FUTURE OF SICIENTIFIC WELLNESS 

6567
04:17:16,565 --> 04:17:20,469
AND THE OTHER ON HEALTH SPAN.

6568
04:17:20,469 --> 04:17:20,836
WE PUT THOSE ON.

6569
04:17:20,836 --> 04:17:22,905
CRAIG MUNDY'S NEW BOOK ON 

6570
04:17:22,905 --> 04:17:25,674
GENESIS, IT IS A SPECTACULAR 

6571
04:17:25,674 --> 04:17:28,077
BOOK YOU SHOULD READ ON AI 

6572
04:17:28,077 --> 04:17:29,645
BECAUSE IT GIVES YOU THE 

6573
04:17:29,645 --> 04:17:31,246
HISTORY, IT GIVES YOU WHERE IT 

6574
04:17:31,246 --> 04:17:33,048
IS GOING TO GO AND ASKS THE 

6575
04:17:33,048 --> 04:17:34,883
CRITICAL QUESTION OF HOW CAN WE 

6576
04:17:34,883 --> 04:17:37,019
CONTROL THIS IN AN APPROPRIATE 

6577
04:17:37,019 --> 04:17:37,419
WAY?

6578
04:17:37,419 --> 04:17:39,355
AND CRAIG HAS BEEN A GOOD FRIEND

6579
04:17:39,355 --> 04:17:42,758
AND WE DEBATED ALL OF THESE 

6580
04:17:42,758 --> 04:17:43,092
THINGS.

6581
04:17:43,092 --> 04:17:45,761
SO THOSE ARE -- WE COULD FOCUS 

6582
04:17:45,761 --> 04:17:46,929
IT WITH THESE THINGS ANY WAY YOU

6583
04:17:46,929 --> 04:17:48,564
WANT TO FOCUS IT.

6584
04:17:48,564 --> 04:17:50,499
AND WHAT YOU DO IS YOU COULD 

6585
04:17:50,499 --> 04:17:53,602
HAVE A CHATBOT THAT COULD DO 

6586
04:17:53,602 --> 04:17:55,637
EVERYTHING PLUS WHAT YOU WANTED.

6587
04:17:55,637 --> 04:17:58,107
SO IT ISN'T THAT WE HAVE TO DO 

6588
04:17:58,107 --> 04:17:59,875
ONE FOR EACH NEW THING.

6589
04:17:59,875 --> 04:18:02,811
IT'S WE ADD IN YOUR PARTICULAR 

6590
04:18:02,811 --> 04:18:04,880
AREA AND MAKE SURE IT KNOWS 

6591
04:18:04,880 --> 04:18:06,548
EVERYTHING THAT IS KNOWN ABOUT 

6592
04:18:06,548 --> 04:18:08,117
IT AND IT WILL BE ABLE TO ANSWER

6593
04:18:08,117 --> 04:18:09,418
YOUR QUESTIONS.

6594
04:18:09,418 --> 04:18:13,322
>> THANK YOU SO MUCH.

6595
04:18:13,322 --> 04:18:14,156
>> ANY OTHER COUNCIL
QUESTIONS 

6596
04:18:14,156 --> 04:18:20,396
FOR LEE?

6597
04:18:20,396 --> 04:18:21,530
WELL, THANK YOU LEE.

6598
04:18:21,530 --> 04:18:23,098
WE ARE SHORT ON TIME BECAUSE WE 

6599
04:18:23,098 --> 04:18:26,101
WERE SUPPOSED TO CLOSE AT 3:00.

6600
04:18:26,101 --> 04:18:28,637
AND I WANTED TO LEAVE IT OPEN 

6601
04:18:28,637 --> 04:18:34,143
FOR QUESTIONS FOR THE PRESENTERS

6602
04:18:34,143 --> 04:18:37,479
OF THE ABCD, AND DATA ANALYSIS 

6603
04:18:37,479 --> 04:18:37,946
GROUP.

6604
04:18:37,946 --> 04:18:40,816
SO ARE THERE ANY COUNCIL 

6605
04:18:40,816 --> 04:18:43,552
QUESTIONS ON THESE LARGE 

6606
04:18:43,552 --> 04:18:43,786
COHORTS?

6607
04:18:43,786 --> 04:18:45,421
I'D BE INTERESTED, LEE, IF YOU 

6608
04:18:45,421 --> 04:18:49,491
HEARD THOSE PRESENTATIONS WHAT 

6609
04:18:49,491 --> 04:18:52,461
YOU THINK OF THE HOW WE COULD 

6610
04:18:52,461 --> 04:18:55,631
INTEGRATE THAT INFORMATION, 

6611
04:18:55,631 --> 04:18:57,199
DEVELOPMENTAL INFORMATION WITH 

6612
04:18:57,199 --> 04:18:57,533
YOUR PROGRAM.

6613
04:18:57,533 --> 04:19:00,602
>> OH, I THINK THERE ARE
SO MANY

6614
04:19:00,602 --> 04:19:02,604
WAYS THESE THINGS COULD BE 

6615
04:19:02,604 --> 04:19:06,508
INTEGRATED AND BE EFFICIENT.

6616
04:19:06,508 --> 04:19:09,178
AND I MEAN, WHAT IS HAPPENING 

6617
04:19:09,178 --> 04:19:12,081
NOW IS WE ARE ALL REINVENTING 

6618
04:19:12,081 --> 04:19:12,948
WHEELS INDEPENDENTLY.

6619
04:19:12,948 --> 04:19:15,517
WE COULD BE SO EFFICIENT IF WE 

6620
04:19:15,517 --> 04:19:18,153
ADOPTED THE NOT INVENTED HEAR 

6621
04:19:18,153 --> 04:19:19,555
SYNDROME AND TAKE WHAT IS OUT 

6622
04:19:19,555 --> 04:19:20,923
THERE AND USE THE BEST.

6623
04:19:20,923 --> 04:19:22,658
I THINK GETTING TOGETHER AND 

6624
04:19:22,658 --> 04:19:23,992
TALKING ABOUT THESE THINGS COULD

6625
04:19:23,992 --> 04:19:29,331
BE VERY, VERY POWERFUL.

6626
04:19:29,331 --> 04:19:31,166
I WOULD BE WILLING TO COME OUT 

6627
04:19:31,166 --> 04:19:32,234
AND DO IT ANY TIME.

6628
04:19:32,234 --> 04:19:33,502
AND IT WOULD BE FUN.

6629
04:19:33,502 --> 04:19:34,736
I COULD GIVE YOU A TALK ABOUT 

6630
04:19:34,736 --> 04:19:36,171
THE DRUGS, TOO.

6631
04:19:36,171 --> 04:19:40,075
BECAUSE, LOOK, THE DRUGS ARE 

6632
04:19:40,075 --> 04:19:42,711
REALLY GOING TO -- THEY'RE GOING

6633
04:19:42,711 --> 04:19:45,114
TO CHANGE PHARMA EVERY BIT AS 

6634
04:19:45,114 --> 04:19:47,583
MUCH AS DATA-DRIVEN HEALTH IS 

6635
04:19:47,583 --> 04:19:48,417
GOING TO CHANGE HEALTH CARE.

6636
04:19:48,417 --> 04:19:50,018
I CAN GUARANTEE YOU THAT.

6637
04:19:50,018 --> 04:19:51,720
>> WE WOULDN'T HAVE TO USE
TEAMS

6638
04:19:51,720 --> 04:19:54,189
IF YOU COME OUT HERE.

6639
04:19:54,189 --> 04:19:55,424
>> THAT'S RIGHT.

6640
04:19:55,424 --> 04:19:58,594
IF I'M IN PLACE, THAT WOULD BE 

6641
04:19:58,594 --> 04:19:58,861
TERRIFIC.

6642
04:19:58,861 --> 04:19:59,061
YEAH.

6643
04:19:59,061 --> 04:20:02,064
>> LET'S MAKE IT AN
IN-PERSON 

6644
04:20:02,064 --> 04:20:02,598
MEETING.

6645
04:20:02,598 --> 04:20:04,233
ANY OTHER QUESTIONS FROM 

6646
04:20:04,233 --> 04:20:06,235
COUNCIL, PLEASE?

6647
04:20:06,235 --> 04:20:06,935
FOR ANYTHING THAT WE'VE COVERED 

6648
04:20:06,935 --> 04:20:13,142
TODAY?

6649
04:20:13,142 --> 04:20:17,312
>> I HAVE A QUESTION FOR
GAYA.

6650
04:20:17,312 --> 04:20:21,517
IN THINKING ABOUT ABCD, WE HEARD

6651
04:20:21,517 --> 04:20:23,986
THIS GREAT TALK FROM DR. KOOB 

6652
04:20:23,986 --> 04:20:25,854
AND DR. HOOD AS WELL.

6653
04:20:25,854 --> 04:20:27,256
NORA YOU MENTIONED THIS 

6654
04:20:27,256 --> 04:20:29,291
YESTERDAY ABOUT ALCOHOL AND 

6655
04:20:29,291 --> 04:20:30,726
SUBSTANCE USE IMPACTING THE 

6656
04:20:30,726 --> 04:20:32,961
WHOLE BODY AND THIS BEING A 

6657
04:20:32,961 --> 04:20:33,529
WHOLE BODY ISSUE.

6658
04:20:33,529 --> 04:20:36,398
I WONDER IF THERE WILL BE 

6659
04:20:36,398 --> 04:20:38,534
OPPORTUNITIES IN ABCD 

6660
04:20:38,534 --> 04:20:39,835
PARTICULARLY AS OUR YOUTH BECOME

6661
04:20:39,835 --> 04:20:43,238
ADULTS TO TAKE THE FULL BODY, TO

6662
04:20:43,238 --> 04:20:45,874
LOOK AT ADDITIONAL BIOMARKERS 

6663
04:20:45,874 --> 04:20:48,076
BEYOND THE BRAIN.

6664
04:20:48,076 --> 04:20:50,879
LOOKING AT PREDISPOSING FACTORS 

6665
04:20:50,879 --> 04:20:52,581
IS GREAT, BUT WE HAVEN'T GOTTEN 

6666
04:20:52,581 --> 04:20:55,551
ALL OF THE BIOSPECIMENS BECAUSE 

6667
04:20:55,551 --> 04:20:56,084
OF FUNDING.

6668
04:20:56,084 --> 04:20:58,120
I'M WONDERING GOING FORWARD IF 

6669
04:20:58,120 --> 04:21:02,891
WE COULD HAVE A MORE WHOLISTIC 

6670
04:21:02,891 --> 04:21:04,526
AGGREGATED ASSESSMENT OF HUMAN 

6671
04:21:04,526 --> 04:21:05,460
HEALTH.

6672
04:21:05,460 --> 04:21:06,728
INTEGRATING ALCOHOL AND 

6673
04:21:06,728 --> 04:21:09,064
SUBSTANCE USE IN HOW IT IMPACTS 

6674
04:21:09,064 --> 04:21:12,601
NOT JUST THE BRAIN, BUT THE 

6675
04:21:12,601 --> 04:21:14,703
ENTIRE BODY, INFLAMMATORY 

6676
04:21:14,703 --> 04:21:15,604
MARKERS.

6677
04:21:15,604 --> 04:21:18,106
THAT WOULD BE PHENOMENAL FOR OUR

6678
04:21:18,106 --> 04:21:20,442
UNDERSTANDING ESPECIALLY IN A 

6679
04:21:20,442 --> 04:21:20,909
LONGITUDINAL COHORT.

6680
04:21:20,909 --> 04:21:21,410
>> YEAH.

6681
04:21:21,410 --> 04:21:22,544
I AGREE.

6682
04:21:22,544 --> 04:21:26,248
WE ALWAYS WRESTLED IN ABCD WITH 

6683
04:21:26,248 --> 04:21:29,651
THE BALANCE TO NOT PUT UNDUE 

6684
04:21:29,651 --> 04:21:32,154
BURDEN ON PARTICIPANTS AND 

6685
04:21:32,154 --> 04:21:33,622
COLLECT THE DATA WE NEED.

6686
04:21:33,622 --> 04:21:41,897
WE DO HAVE BIOSPES -- 

6687
04:21:41,897 --> 04:21:46,602
BIOSPECIMENS THAT ARE BANKED.

6688
04:21:46,602 --> 04:21:49,238
WE HAVE THINGS THAT INCLUDE 

6689
04:21:49,238 --> 04:21:50,772
HEALTH AND WELL BEING SO WE CAN 

6690
04:21:50,772 --> 04:21:53,008
GET INPUT ON HOW THAT MIGHT BE 

6691
04:21:53,008 --> 04:21:53,342
INCORPORATED.

6692
04:21:53,342 --> 04:21:59,881
>> THANK YOU.

6693
04:21:59,881 --> 04:22:01,016
>> ANY OTHER COMMENTS OR 

6694
04:22:01,016 --> 04:22:01,283
QUESTIONS?

6695
04:22:01,283 --> 04:22:07,623
PLEASE.

6696
04:22:07,623 --> 04:22:08,824
OTHERWISE, I'M TURNING IT BACK 

6697
04:22:08,824 --> 04:22:09,925
TO YOU, NORA.

6698
04:22:09,925 --> 04:22:13,695
BECAUSE YOU HAVE ON THE 

6699
04:22:13,695 --> 04:22:21,236
SCHEDULE, THE WRAPUP, CLOSING 

6700
04:22:21,236 --> 04:22:21,536
REMARKS.

6701
04:22:21,536 --> 04:22:23,805
A YOU HAVE ABOUT 10 MINUTES IF 

6702
04:22:23,805 --> 04:22:25,774
THERE ARE THINGS YOU WANT TO 

6703
04:22:25,774 --> 04:22:29,911
TELL EVERYBODY IN ADDITION TO 

6704
04:22:29,911 --> 04:22:30,479
THAT.

6705
04:22:30,479 --> 04:22:30,679
OKAY.

6706
04:22:30,679 --> 04:22:33,782
IT IS ALL YOURS, NORA.

6707
04:22:33,782 --> 04:22:36,351
>> GEORGE, THANKS VERY
MUCH.

6708
04:22:36,351 --> 04:22:40,756
THERE IS A LATE MOTIVE IN THE 

6709
04:22:40,756 --> 04:22:41,823
SUBJECTS PRESENTED TODAY.

6710
04:22:41,823 --> 04:22:44,293
THAT COMES TO SAY WHAT IS IT 

6711
04:22:44,293 --> 04:22:46,495
THAT IS IMPRINTED ON MY BRAIN 

6712
04:22:46,495 --> 04:22:48,430
TODAY FROM ALL THE DISCUSSIONS 

6713
04:22:48,430 --> 04:22:50,465
THE NOTION THAT WE ARE NOW IN 

6714
04:22:50,465 --> 04:22:53,735
THE AREA OF SCIENTIFIC 

6715
04:22:53,735 --> 04:22:54,903
FINALIZING COMPLEXITY.

6716
04:22:54,903 --> 04:22:57,606
THE COMPLEXITY HAS MULTIPLE 

6717
04:22:57,606 --> 04:22:57,839
SHAPES.

6718
04:22:57,839 --> 04:23:00,776
BUT FOR US TO BE ABLE TO 

6719
04:23:00,776 --> 04:23:03,211
MAXIMIZE OUR SUCCESS IN DOING 

6720
04:23:03,211 --> 04:23:04,780
THAT WE REQUIRE TO CHANGE 

6721
04:23:04,780 --> 04:23:06,515
BASICALLY THE WAY THAT WE HAVE 

6722
04:23:06,515 --> 04:23:07,316
BEEN DOING SCIENCE.

6723
04:23:07,316 --> 04:23:12,387
AND ONE OF THE BIG CHALLENGES IS

6724
04:23:12,387 --> 04:23:14,756
HOW DO WE INTEGRATE OUR EFFORTS 

6725
04:23:14,756 --> 04:23:16,091
WITHIN THE NIH, WITHIN THE 

6726
04:23:16,091 --> 04:23:18,160
VARIOUS PROGRAMS THAT ARE 

6727
04:23:18,160 --> 04:23:21,463
PRESENTED LIKE BOTH FROM HBCD 

6728
04:23:21,463 --> 04:23:24,933
AND ABCD AND ALL OF US AND OTHER

6729
04:23:24,933 --> 04:23:27,703
PROJECTS SO WE CAN MAXIMIZE IT.

6730
04:23:27,703 --> 04:23:29,705
HOW DO WE PREPARE THE FIELD?

6731
04:23:29,705 --> 04:23:31,173
HOW DO WE ADVANCE IT?

6732
04:23:31,173 --> 04:23:33,575
THAT IS EASIER SAID THAN DONE.

6733
04:23:33,575 --> 04:23:35,477
I THINK THAT PULLING OUR HEADS 

6734
04:23:35,477 --> 04:23:38,347
TOGETHER IN A WAY THAT HOW DO WE

6735
04:23:38,347 --> 04:23:41,950
DO IT SCIENTIFICALLY, BUT 

6736
04:23:41,950 --> 04:23:44,820
ULTIMATELY, TOO, WITH THE GOAL 

6737
04:23:44,820 --> 04:23:46,988
BECAUSE AS I WAS LISTENING, IT 

6738
04:23:46,988 --> 04:23:48,423
IS EXTRAORDINARY IF WE CAN START

6739
04:23:48,423 --> 04:23:51,460
TO DETERMINE WHO IS AT RISK AND 

6740
04:23:51,460 --> 04:23:54,730
WHAT WOULD BE THEIR PERSONALIZED

6741
04:23:54,730 --> 04:23:55,063
INTERVENTION?

6742
04:23:55,063 --> 04:23:57,566
THE ISSUE THAT WE CANNOT KEEP 

6743
04:23:57,566 --> 04:23:59,801
OUR EYES OFF THE BALL IS WE WANT

6744
04:23:59,801 --> 04:24:01,236
THAT TO BECOME ACCESSIBLE TO 

6745
04:24:01,236 --> 04:24:01,503
EVERYONE.

6746
04:24:01,503 --> 04:24:02,938
WHAT WE DON'T WANT IS ALL OF 

6747
04:24:02,938 --> 04:24:07,342
THESE ADVANCES TO THEN BE 

6748
04:24:07,342 --> 04:24:08,410
AVAILABLE TO VERY RESTRICTED 

6749
04:24:08,410 --> 04:24:11,880
GROUP OF PEOPLE AND YOU JUST 

6750
04:24:11,880 --> 04:24:14,049
EXACERBATE THE GAP BETWEEN THOSE

6751
04:24:14,049 --> 04:24:16,952
THAT ARE GOING TO HAVE OPTIMAL 

6752
04:24:16,952 --> 04:24:17,953
HEALTH WHILE BASICALLY PAYING A 

6753
04:24:17,953 --> 04:24:19,755
PRICE FOR THE REST OF THE 

6754
04:24:19,755 --> 04:24:21,456
POPULATION THAT LAGS BEHIND.

6755
04:24:21,456 --> 04:24:23,258
IF I WERE TO PUT A POINT, THAT 

6756
04:24:23,258 --> 04:24:26,795
IS ONE OF THE BIG CHALLENGES 

6757
04:24:26,795 --> 04:24:29,197
THAT WE HAVE WITH AMERICA.

6758
04:24:29,197 --> 04:24:30,899
WE SPEND HUGE AMOUNTS OF AMERICA

6759
04:24:30,899 --> 04:24:32,768
BUT AT THE POPULATION LEVEL WE 

6760
04:24:32,768 --> 04:24:34,269
ARE DOING VERY POORLY.

6761
04:24:34,269 --> 04:24:36,104
I THINK THIS IS TRANSFORMATIVE, 

6762
04:24:36,104 --> 04:24:38,407
THE SCIENCE, AND IT WILL REQUIRE

6763
04:24:38,407 --> 04:24:40,442
THAT WE MODIFY ALSO THE WAY THAT

6764
04:24:40,442 --> 04:24:42,677
WE CONCEIVE OF MEDICINE AND 

6765
04:24:42,677 --> 04:24:45,614
HEALTH, INCLUDING WELLNESS.

6766
04:24:45,614 --> 04:24:48,817
HOW WE TRACK IT.

6767
04:24:48,817 --> 04:24:50,786
BUT ALSO THE POLICIES AND THE 

6768
04:24:50,786 --> 04:24:52,721
STRUCTURES OF THE SYSTEMS THAT 

6769
04:24:52,721 --> 04:24:56,391
ARE RESPONSIBILITY FOR PROVIDES 

6770
04:24:56,391 --> 04:24:57,359
IT.

6771
04:24:57,359 --> 04:24:58,226
AGAIN, HIGHLIGHT HOW IMPORTANT 

6772
04:24:58,226 --> 04:25:00,128
IT IS FOR ALL OF US TO WORK 

6773
04:25:00,128 --> 04:25:02,130
TOGETHER HERE IN THE ACADEMIC 

6774
04:25:02,130 --> 04:25:02,364
CENTERS.

6775
04:25:02,364 --> 04:25:04,699
I ALSO THINK IT IS CRUCIAL AND 

6776
04:25:04,699 --> 04:25:08,470
COMES ACROSS THAT WE NEED TO 

6777
04:25:08,470 --> 04:25:10,605
INTERACT WITH THE OTHER 

6778
04:25:10,605 --> 04:25:10,872
AGENCIES.

6779
04:25:10,872 --> 04:25:12,541
EVEN THOUGH THEY MAY BE OUTSIDE 

6780
04:25:12,541 --> 04:25:14,776
THE POLICY, THEY ARE THE ONES 

6781
04:25:14,776 --> 04:25:18,013
PROVIDING THAT SUPPORT FOR THE 

6782
04:25:18,013 --> 04:25:19,948
POPULATION THAT REQUIRES 

6783
04:25:19,948 --> 04:25:22,884
ACTUALLY HELP WITH THEIR HEALTH.

6784
04:25:22,884 --> 04:25:24,519
I ALSO THINK THE OTHER MOTIVE 

6785
04:25:24,519 --> 04:25:28,390
THAT IS IMPRINTED TO ME AS A 

6786
04:25:28,390 --> 04:25:30,125
FUNCTIONAL OF ALL OF THE 

6787
04:25:30,125 --> 04:25:31,960
DISCUSSIONS IS THE WHOLE CONCEPT

6788
04:25:31,960 --> 04:25:33,762
OF HOW CRUCIAL PREVENTION IS AND

6789
04:25:33,762 --> 04:25:36,398
HOW WITH ALL THE SCIENCE THAT IS

6790
04:25:36,398 --> 04:25:39,334
BEING DEVELOPED AND THESE 

6791
04:25:39,334 --> 04:25:41,536
BIOMARKERS, HOW WE CAN CONCEIVE 

6792
04:25:41,536 --> 04:25:45,607
OF PREVENTION IN A DIFFERENT 

6793
04:25:45,607 --> 04:25:45,941
WAY.

6794
04:25:45,941 --> 04:25:47,509
AND HAVING THAT PREVENTION AND I

6795
04:25:47,509 --> 04:25:49,444
THINK THAT DR. LEE HOOD'S 

6796
04:25:49,444 --> 04:25:50,879
PRESENTATION CLEARLY SHOWED IT, 

6797
04:25:50,879 --> 04:25:53,615
IS WE CANNOT THINK OF A SYSTEM 

6798
04:25:53,615 --> 04:25:55,650
IN ISOLATION.

6799
04:25:55,650 --> 04:25:57,052
I SORT OF SAID, OF COURSE, I 

6800
04:25:57,052 --> 04:25:58,553
ALWAYS THINK ABOUT THE BRAIN.

6801
04:25:58,553 --> 04:26:00,255
TO ME, EVERYTHING IS THE BRAIN.

6802
04:26:00,255 --> 04:26:01,623
BUT THE REALITY IS THAT ONE OF 

6803
04:26:01,623 --> 04:26:06,995
THE FACTORS THAT PREDICT THE 

6804
04:26:06,995 --> 04:26:09,731
BRAIN IS CARDIOVASCULAR 

6805
04:26:09,731 --> 04:26:12,133
FUNCTION, METABOLIC PROCESSES.

6806
04:26:12,133 --> 04:26:14,736
SO HOW DO WE BRING TOGETHER THAT

6807
04:26:14,736 --> 04:26:18,773
COMPREHENSIVE PATTERN IN THE 

6808
04:26:18,773 --> 04:26:22,244
NOTION OF PREVENTION?

6809
04:26:22,244 --> 04:26:23,211
UNFORTUNATELY, DRUGS DISRUPT 

6810
04:26:23,211 --> 04:26:25,981
MULTIPLE OF THESE PROCESSES.

6811
04:26:25,981 --> 04:26:28,416
DEPENDING ON YOUR LEVEL OF RISK 

6812
04:26:28,416 --> 04:26:30,285
IN THAT PARADIGM, YOU MAY 

6813
04:26:30,285 --> 04:26:32,687
BASICALLY THROW YOU OFF THE 

6814
04:26:32,687 --> 04:26:34,523
CLIFF OR YOU MAY HAVE THE 

6815
04:26:34,523 --> 04:26:36,625
RESILIENCE TO ACTUALLY 

6816
04:26:36,625 --> 04:26:38,827
ACCOMMODATE FOR THE TOXICITY OF 

6817
04:26:38,827 --> 04:26:41,530
DRUGS, DEPENDING ON A WIDE 

6818
04:26:41,530 --> 04:26:43,331
VARIETY OF FACTORS.

6819
04:26:43,331 --> 04:26:44,399
UNDERSTANDING THEM BECOMES VERY,

6820
04:26:44,399 --> 04:26:46,568
VERY RELEVANT.

6821
04:26:46,568 --> 04:26:49,137
AS WE LAUNCH INTO FOR US IN THE 

6822
04:26:49,137 --> 04:26:51,172
FIELD OF SUBSTANCE USE DISORDERS

6823
04:26:51,172 --> 04:26:53,341
IS HOW DO WE PARTICIPATE IN THIS

6824
04:26:53,341 --> 04:26:56,011
PROCESS SO THAT WE CAN MAKE IT 

6825
04:26:56,011 --> 04:26:59,514
CLEAR THAT WE CANNOT CONTINUE TO

6826
04:26:59,514 --> 04:27:01,483
IGNORE THE PRESENCE OF 

6827
04:27:01,483 --> 04:27:03,084
SUBSTANCES AND THE BURDEN THAT 

6828
04:27:03,084 --> 04:27:04,719
THEY PUT INTO INDIVIDUALS.

6829
04:27:04,719 --> 04:27:07,222
AND I DO WANT TO SAY SOMETHING 

6830
04:27:07,222 --> 04:27:11,693
THAT MAY BE A LITTLE BIT 

6831
04:27:11,693 --> 04:27:13,128
SENSITIVE, BUT YOU KNOW ME, I 

6832
04:27:13,128 --> 04:27:14,129
DON'T STOP THERE.

6833
04:27:14,129 --> 04:27:17,065
IS THE NOTION OF CONSIDERING 

6834
04:27:17,065 --> 04:27:20,602
WHAT ARE THE COMMERCIAL 

6835
04:27:20,602 --> 04:27:22,003
INTERESTS THAT ARE CONTRIBUTING 

6836
04:27:22,003 --> 04:27:24,706
TO THIS PATHOLOGY?

6837
04:27:24,706 --> 04:27:26,908
IN THE FIELD WE ARE IN, DRUGS, 

6838
04:27:26,908 --> 04:27:30,412
THEY ARE DRIVEN BY INCENTIVES 

6839
04:27:30,412 --> 04:27:33,348
FOR FUNDING, FOR ACTUALLY MAKING

6840
04:27:33,348 --> 04:27:34,849
MONEY, THE DRUG DEALERS.

6841
04:27:34,849 --> 04:27:38,053
SORT OF SELLING PRODUCTS.

6842
04:27:38,053 --> 04:27:39,321
TOBACCO, MARIJUANA, ALCOHOL, HOW

6843
04:27:39,321 --> 04:27:41,690
DO WE GENERATE THE DIALOGUE TO 

6844
04:27:41,690 --> 04:27:45,126
BRING THAT ALSO INTO TA PLACE 

6845
04:27:45,126 --> 04:27:47,796
WHY IT IS SO IMPORTANT, YES, WE 

6846
04:27:47,796 --> 04:27:50,198
CAN DO THE SCIENCE, BUT WORKING 

6847
04:27:50,198 --> 04:27:53,668
WITH THE OTHER AGENCIES IN A 

6848
04:27:53,668 --> 04:27:54,369
COMPREHENSIVE FASHION.

6849
04:27:54,369 --> 04:27:56,805
I THINK IT IS ANOTHER ASPECT 

6850
04:27:56,805 --> 04:28:02,277
THAT IS LEFT TO ME AFTER HAVING 

6851
04:28:02,277 --> 04:28:03,645
WATCHED ALL THE WONDERFUL 

6852
04:28:03,645 --> 04:28:03,979
PRESENTATIONS.

6853
04:28:03,979 --> 04:28:06,181
I DO WANT TO END BY SAYING IT 

6854
04:28:06,181 --> 04:28:08,483
HAS BEEN A REMARKABLE PLEASURE 

6855
04:28:08,483 --> 04:28:11,386
TO WORK COLLABORATIVELY WITH THE

6856
04:28:11,386 --> 04:28:12,621
ALCOHOL INSTITUTE, THE CANCER 

6857
04:28:12,621 --> 04:28:14,189
INSTITUTE AND TO MAKE THE STUDY 

6858
04:28:14,189 --> 04:28:15,757
OF THE ABCD POSSIBLE.

6859
04:28:15,757 --> 04:28:19,361
THAT ACTUALLY INSPIRED THE HBCD.

6860
04:28:19,361 --> 04:28:20,929
AND WHICH ALREADY HAS 

6861
04:28:20,929 --> 04:28:24,332
TRANSFORMED OUR UNDERSTANDING OF

6862
04:28:24,332 --> 04:28:24,933
BRAIN DEVELOPMENT.

6863
04:28:24,933 --> 04:28:27,669
AND GIVEN US A PLATFORM TO 

6864
04:28:27,669 --> 04:28:29,604
ACTUALLY JUSTIFY INTERVENTIONS 

6865
04:28:29,604 --> 04:28:31,373
THAT IN THE PAST WE WOULD NOT 

6866
04:28:31,373 --> 04:28:35,744
HAVE THE EVIDENCE TO DO SO.

6867
04:28:35,744 --> 04:28:37,445
SO I'M VERY, VERY GRATEFUL FOR 

6868
04:28:37,445 --> 04:28:37,646
THAT.

6869
04:28:37,646 --> 04:28:39,547
I'M VERY GRATEFUL FOR MY TEAM, 

6870
04:28:39,547 --> 04:28:42,150
WHICH HAS ACTUALLY DONE AN 

6871
04:28:42,150 --> 04:28:45,754
OUTSTANDING JOB AND FOR THE 

6872
04:28:45,754 --> 04:28:49,858
PARTNERSHIP WITH NIAAA AND NCI 

6873
04:28:49,858 --> 04:28:51,626
AND I'M GRATEFUL FOR COUNCIL TO 

6874
04:28:51,626 --> 04:28:54,696
GIVE US INPUT BECAUSE LIKE 

6875
04:28:54,696 --> 04:29:02,103
ANYTHING ELSE IN LIFE, WE ALL 

6876
04:29:02,103 --> 04:29:07,042
NEED TO -- HOW DO WE PROTECT 

6877
04:29:07,042 --> 04:29:08,943
PROJECTS WHEN PROJECTS MAY BE 

6878
04:29:08,943 --> 04:29:09,277
CHANGING?

6879
04:29:09,277 --> 04:29:15,316
HOW DO WE DO IT IN A WAY  THAT 

6880
04:29:15,316 --> 04:29:17,352
MAXIMIZES THE IMPACT OF THE DATA

6881
04:29:17,352 --> 04:29:19,187
AND KNOWLEDGE WE ARE GATHERING.

6882
04:29:19,187 --> 04:29:21,923
WE RELY ON ALL OF YOU FOR THAT.

6883
04:29:21,923 --> 04:29:23,525
THERE IS NOT ONE SINGLE PERSON 

6884
04:29:23,525 --> 04:29:24,826
WHO HAS THE ANSWER.

6885
04:29:24,826 --> 04:29:29,564
THANKS FOR YOUR WILLINGNESS TO 

6886
04:29:29,564 --> 04:29:30,465
BE HERE.

6887
04:29:30,465 --> 04:29:31,666
GEORGE, I WILL TURN IT BACK TO 

6888
04:29:31,666 --> 04:29:33,735
YOU FOR THE FINAL, FINAL 

6889
04:29:33,735 --> 04:29:33,968
COMMENT.

6890
04:29:33,968 --> 04:29:37,605
>> I JUST WANT TO THANK 

6891
04:29:37,605 --> 04:29:38,206
EVERYONE, ESPECIALLY MY 

6892
04:29:38,206 --> 04:29:40,008
COLLEAGUES AT NIDA AND NCI AS 

6893
04:29:40,008 --> 04:29:44,079
WELL BECAUSE WE REALLY ENJOY OUR

6894
04:29:44,079 --> 04:29:44,779
COLLABORATION.

6895
04:29:44,779 --> 04:29:49,117
IT'S JUST BEEN SO FRUITFUL.

6896
04:29:49,117 --> 04:29:53,655
THE ABCD STUDY IS A GEM IN THE 

6897
04:29:53,655 --> 04:29:55,824
PANOPLY OF GEMS AT NIH AND I 

6898
04:29:55,824 --> 04:29:57,759
THINK THE HBCD STUDY IS GOING TO

6899
04:29:57,759 --> 04:29:59,861
BE EQUALLY IMPORTANT AND, YOU 

6900
04:29:59,861 --> 04:30:03,331
KNOW, WHEN I SAW LEE HOOD COULD 

6901
04:30:03,331 --> 04:30:04,532
PREDICT WHAT WAS GOING TO HAPPEN

6902
04:30:04,532 --> 04:30:07,736
TO A CHILD BASED ON THE 

6903
04:30:07,736 --> 04:30:09,404
PLACENTA, I THOUGHT, MY 

6904
04:30:09,404 --> 04:30:10,905
GOODNESS, WHAT MORE CAN WE DO 

6905
04:30:10,905 --> 04:30:12,807
THAT IS GOING TO BE FABULOUS.

6906
04:30:12,807 --> 04:30:14,709
THIS HAS BEEN A GREAT COUNCIL.

6907
04:30:14,709 --> 04:30:17,245
I'M SORRY YOU ALL WEREN'T HERE.

6908
04:30:17,245 --> 04:30:20,115
MAYBE IN SEPTEMBER NEXT YEAR WE 

6909
04:30:20,115 --> 04:30:21,716
CAN ALL GET TOGETHER IN 

6910
04:30:21,716 --> 04:30:22,250
SEPTEMBER.

6911
04:30:22,250 --> 04:30:24,819
MAYBE WE HAVE LIVE COUNCILS FOR 

6912
04:30:24,819 --> 04:30:26,588
OUR OWN INSTITUTE IN ANY EVENT.

6913
04:30:26,588 --> 04:30:28,890
I AM THE ETERNAL OPTIMIST AS 

6914
04:30:28,890 --> 04:30:31,593
WELL JUST LIKE NORA AND JUST 

6915
04:30:31,593 --> 04:30:32,460
LIKE LEE HOOD.

6916
04:30:32,460 --> 04:30:35,797
SO I HOPE THAT IS INFERKS WITH 

6917
04:30:35,797 --> 04:30:46,107
YOU  -- INFECTION.

6918
04:30:46,674 --> 04:30:48,710
THANKS PHILIPPE FOR ALL THE 

6919
04:30:48,710 --> 04:30:48,943
SLIDES.

6920
04:30:48,943 --> 04:30:51,713
I THINK HE FELT LIKE HE GAVE A 

6921
04:30:51,713 --> 04:30:51,913
TALK.

6922
04:30:51,913 --> 04:30:52,447
SO GOOD-BYE EVERYBODY.

6923
04:30:52,447 --> 04:31:02,657
>> GOOD-BYE.