WELCOME.
I'D LIKE TO INTRODUCE OUR
COUNCIL MEMBERS AND EACH OF
THEM, YOU KNOW, UNMUTE AND
UNVIDEO AND INTRODUCE THEMSELVES
AND I'M GOING TO GO BY
ALPHABETICAL ORDER SO YOU KNOW
WHEN YOU ARE GOING TO BE CALLED
UPON.
SO, I'D LIKE TO START WITH NANCY
BARNETT.
>> HI, GEORGE.
I'M SORRY, I JUST GOT ON.
YOU WANT JUST AN INTRODUCTION?
>> JUST TELL US WHO YOU ARE AND
WHAT YOU DO.
QUICKLY.
>> PROFESSOR AT BROWN UNIVERSITY
SCHOOL OF PUBLIC-HEALTH AND I
STUDY ADOLESCENTS AND YOUNG
ADULTS IN ALCOHOL USE.
>> THANK YOU.
>> Dr. JILL BECKER.
>> HI, I'M JILL BECKER AT THE
UNIVERSITY OF MICHIGAN IN THE
DEPARTMENTS OF PSYCHOLOGY AND
THE MICHIGAN NEUROSCIENCE
INSTITUTE AND I STUDY SEX
DIFFERENCES IN ADDICTION.
>> THANK YOU, JILL.
>> Dr. ANDREW CAMERON.
>> HELLO, ANDREW CAMERON FROM
JOHNS HOPKINS.
THANK YOU FOR HAVING ME.
>> AND Dr. CHRISTOPHER
CARPENTER.
I'M KIT CARPENTER AND I STUDY
LGBTQ POPULATIONS.
>> Dr. CHRISTINA CHAMBERS.
>> THANK YOU, I'M TINA CHAMBERS
AND I'M A PROFESSOR IN
DEPARTMENT OF PEDIATRICS AND THE
SCHOOL OF PUBLIC-HEALTH AT UC
SAN DIEGO AND I STUDY FETAL
ALCOHOL SPECTRUM DISORDERS.
>> THANK YOU.
>> THANK YOU, WES.
>> DOCTOR CONSTANCE MORGAN.
>> I'M A PROFESSOR AT THE HELLER
SCHOOL AND DIRECTOR OF THE
INSTITUTES FOR BEHAVIORAL HEALTH
AND I DO RESEARCH AND ALCOHOL
HEALTH RESEARCH.
>> BETH KING DAVIDSON.
>>
>> GOOD AFTERNOON, I'M A
PROFESSOR OF DIVISION OF EPI AND
COMMUNITY HEALTH AT THE
UNIVERSITY OF MINNESOTA SCHOOL
OF PUBLIC-HEALTH AND MY RESEARCH
FOCUSES ON ALCOHOL EPIDEMIOLOGY
AND (INAUDIBLE) WITH A FOCUS ON
RACE, SOCIAL CLASS AND
NEIGHBORHOOD INFLUENCES.
>> THANK YOU, RHONDA.
AND Dr. CHARLES LANG.
>> CHUCK LANG I'M INTERESTED IN
ALCOHOL'S EFFECT ON CARDIAC AND
SKELESKELETAL MUSCLE.
>> THANK YOU, CHUCK.
>> Dr. MARY LARRYMER.
>> I'M MARY A PROFESSOR OF
PSYCHIATRY AND BEHAVIORAL
SCIENCE AND PSYCHOLOGY AT
UNIVERSITY OF WASHINGTON AND I
STUDY PREVENTION AND TREATMENT
OF ALCOHOL USE DISORDERS AND
RELATED CO MORBID CONDITIONS
PRIMARILY IN YOUNG ADULT
POPULATIONS.
>> THANK YOU, MARY.
Dr. LAURA NAGY.
>> HI, I'M LAW A NAGY A
CLEVELAND CLINIC AND I'M
INTERESTED IN IMMUNITY AND
ALCOHOL ASSOCIATED LIVER
DISEASE.
>> THANK YOU, LAURA.
AND Dr. SCOTT RUSSO.
>> HI, THERE, SCOTT RUSSO
PROFESSOR OF NEUROSCIENCE AT
MOUNT SINAI AND MY LAB STUDIES
STRESS, DISORDERS.
>> Dr. SULLIVAN.
>> EDIE HAS RETIRED.
I DON'T KNOW HOW THAT GOT ON MY
LIST.
I THOUGHT SO.
I THOUGHT WE RETIRED OUR CHER.
>> I'M FROM THE ALCOHOL
SUBSTANCE ABUSE AND I FOCUS ON
BEHAVIORAL AND RECOVERY.
THANK YOU.
>> THANK YOU CHARLES MILLIKEN.
>> THANK YOU.
I'M CHUCK MILLIKEN AND DIRECTOR
OF SUB USE SERVICES WHICH IS
PRIMARILY ALCOHOL FOR THE ARMY
SURGEON GENERAL STAFF.
THANK YOU.
>> THANK YOU, CHUCK.
ALL RIGHT.
SO THAT'S EVERYONE FROM THE
COUNCIL.
THANK YOU ALL SO MUCH FOR BEING
ON COUNCIL AND HELPING US WITH
THIS EFFORTS.
I LOOK FORWARD TO ANY COMMENTS
AND ADVICE YOU HAVE AS WE MOVE
ALONG THROUGH THE DAY.
OWE WOULD LIKE TO INTRODUCE OUR
SENIOR STAFF.
I WOULD LIKE THE STAFF MEMBERS
TO SAY WHAT THEIR
RESPONSIBILITIES ARE AT NIAAA.
I'M THE DIRECTOR EVERYBODY KNOWS
THAT.
PATRICIA POWELL.
>> HI, I'M TRISH POWELL THE
DEPUTY DIRECTOR AT NIAAA.
GOOD AFTERNOON TO EVERYONE.
WE MISSED LAURA ADELE.
>> MY GOODNESS.
MY FORMER POSTDOC AND STAFF
SCIENTIST AND I LEFT HER OUT IN
THE COLD.
I CAN'T BELIEVE IT.
ALL RIGHT.
LET'S LOOP BACK.
Dr. LAURA O'DELL.
>> THAT'S OK.
NICE TO SEE EVERYONE.
MY NAME IS LAURA O'DELL AND I'M
A PROFESSOR OF NEUROSCIENCE AT
THE UNIVERSITY OF TEXAS AT EL
PASO AND MY RESEARCH INTEREST IN
TRYING TO UNDERSTAND DRUG USE
AND VULNERABLE POPULATIONS.
>> THANK YOU, LAURA.
I APOLOGIZE FOR SKIPPING THAT.
I DON'T KNOW WHAT HAPPENED
THERE.
>> I AM FOCUSING ON THE
GOVERNMENT OF EDIE SULLIVAN OR
SOMETHING.
AND I WANT TO MENTION IT'S Dr.
PATRICIA POWELL SO I WANT THAT
TO BE CLEAR TO EVERYBODY AND WE
CALL HER TRISH.
SHE'S THE DEPUTY AND SHE'S
INTRODUCED HERSELF AND Ms.
VICKY BUCKLEY.
>> HI, I'M VICKY BUCKLEY I'M THE
DEPUTY ETHICS COUNCILOR.
GOOD AFTERNOON.
EVERYONE.
>> Dr. CATHY YOUNG.
>> HELLO, EVERYONE.
I'M CATHY YOUNG THE DIRECTOR OF
THE DIVISION OF METABOLISM THAT
LOOKS AT THE EFFECTS OF ALCOHOL
AND ORGAN AND TISSUE DAMAGE.
>> Dr. ANTONIO NERONO.
>> HE MAY HAVE MICROPHONE
PROBLEMS.
LET'S GO TO Dr. RAY.
>> I'M THE DIRECTOR OF DIVISION
OF TREATMENT AND HE RECOVERY
RESEARCH AND WE'RE RESPONSIBLE
FOR TREATMENT, HEALTH SERVICES,
RECOVERY AND MEDICATIONS
DEVELOPMENT.
>> Dr. RALPH HINKSON.
>> AGAIN, WE MAY HAVE A
MICROPHONE PROBLEM.
Dr. BRIGITTE WILLIAMS SIMMONS.
>> GOOD AFTERNOON.
I'M BRIGITTE WILLIAMS SIM ONLY
THE DIRECTOR OF OFFICE OF
SCIENCE POLICY AND
COMMUNICATIONS AND THE ASSOCIATE
DIRECTOR FOR BASIC RESEARCH FOR
NIAAA.
>> Dr. DAVID LOVENGER.
>> YES, DAVID AND I'M THE ACTING
SCIENTIFIC DIRECTOR OF THE
DIVISION OF INTERMURAL CLINICAL
EX BIOLOGICAL RESEARCH.
>> THANK YOU, DAVE.
AND Dr. DAVID GOLDMAN.
>> HI, I'M DAVID GOLDMAN,
CLINICAL DIRECTOR.
>> AND Dr. ABE BAUTISTA.
>> HI, I'M ABE BAUTISTA THE
EXECUTIVE SECRETARY OF COUNCIL
AND DIRECTOR OF OEA AND OF
NIAAA.
ANTONIO'S ARE YOU OUT THERE?
>>ER RALPH.
AND PREVENTION RESEARCH SO
OCCASIONALLY, ANTONIO AND RALPH
HAVE TROUBLE WITH MICROPHONES.
I'M NOT SURE WHAT THE ISSUE IS
BUT WE'LL HEAR FROM THEM LATER.
SO, THANK YOU ALL VERY MUCH.
I JUST WANT YOU TO KNOW THAT IT
IS TIME FOR THE DIRECTOR REPORT
SO IF YOU CAN PUT MY SLIDES UP.
I WOULD BE GRATEFUL.
AND I WANT TO KNOW WHAT I'M
SPEAKING ABOUT IS ACTUALLY IN A
WRITTEN REPORT.
IT WAS PREPARED BY OFFICE OF
SCIENCE, POLICY AND
COMMUNICATIONS LED BY Dr.
BRIGITTE WILLIAMS-SIMMONS.
AND YOU CAN FIND ALL THE DETAILS
THERE.
SO, TIM, CAN I HAVE THE NEXT
SLIDE, PLEASE.
SO THE BUDGET.
SO, ON MARCH 15th, 2022, THE
PRESIDENT SIGNED HR2471 THE
CONSOLIDATED APPROPRIATIONS ACT
FOR 2022.
THIS WAS A RELIEF FOR US BECAUSE
IT TOOK US OUT OF THE
CONDITIONING RESOLUTION AND NIH
RECEIVED $45.2 BILLION FOR 2022
AND THAT WAS A 5.4% INCREASE AND
IT INCLUDED GENERAL INCREASES TO
THE NIH INSTITUTES AND CENTERS
ALLOCATIONS FOR HELPING TO END
ADDICTION LONG-TERM AND IT'S
KNOWN AS THE HEAL INITIATIVE.
AND THE 21st CENTURY CURES
ACT, NIH BRAIN RESEARCH THROUGH
ADVANCING THE INNOVATIVE NEURO
TECHNOLOGIES BRAIN AND THE ALL
OF US RESEARCH PROGRAM.
IT WAS CONTINUED SUPPORT FOR THE
GABRIELA MILLER FUND FIRST ACT
PEDIATRIC RESEARCH INITIATIVE
WITH A TOTAL OF $574 MILLION FOR
FISCAL YEAR 2022.
THAT WAS A 3.4% INCREASE.
THE PRESIDENT'S 2023 BUDGET WAS
RELEASED ON MARCH 28th, 202 #
BUT IT HASN'T BEEN OBVIOUSLY
APPROVED YET.
THE NEXT SLIDE.
WE HAVE FUNDING OPPORTUNITIES.
YOU CAN GET LISTING IN THE
DIRECTOR'S REPORT.
THERE'S SPECIALIZED RESEARCH
CENTERS, THE P50s THAT INVITES
APPLICATIONS TO FOSTER AND
CONDUCT DISCIPLINARY RESEARCH ON
ALCOHOL USE DISORDER, ALCOHOL
MISUSE AND ALCOHOL RELATED
PROBLEMS AND OTHER HEALTH
RELATED CONSEQUENCES ACROSS THE
LIFESPAN AND ACROSS RACIAL
ETHNIC GROUPS AND OTHER HEALTH
DISPARITY POPULATIONS.
YOU CAN SEE THE CONTEXT THERE.
WE HAVE THE P60s AND THE
P50s AND THEY INITIATE AND
EXPAND COMMUNITY EDUCATION AND
RELATED TO THE ACTIVITIES THAT
PROPOSE CENTER.
THERE'S ALCOHOL HOUSE SERVICES
RESEARCH.
PAR AND TWO OF THEM ENCOURAGING
RESEARCH ON CLOSING THE
TREATMENT GAP FOR ALCOHOL USE
DISORDER INCONCLUDESSING
INCREASING ACCESS TO ALCOHOL USE
DISORDER TREATMENT AND MAKING IT
MORE APPEALING AND REDUCING
HEALTH DISPARITIES AND THIS IS
WHAT I HOPE TO BE JUST THE
BEGINNING OF OUR EFFORTS IN
CLOSING THE TREATMENT GAP AND
IT'S SUBJECT OF MY PRESENTATION
TOMORROW AT CRAN.
COLLABORATIVE RESEARCH ON
ADDICTION TO NIH MEETING.
IT WILL BE THE SUBJECT OF MY
PRESENTATION AT RSA AND THE
COLLEGE ON THE PROBLEMS OF DRUG
DEPENDENCE AND THE AMERICAN
SOCIETY OF CLINICAL PSYCHO
PHARMACOLOGY.
IT'S OUR -- AS YOU WILL SEE,
THIS IS GOING TO BE A BIG EFFORT
THIS YEAR FOR DNA.
THEY ENCOURAGE RESEARCH ON
TOPICS RELATIVE TO TREATMENT OF
AND RECOVERY FROM A INCLUDING
THE PHARMA CO THERAPY RECOVERY
PRE SESSION MEDICINE,
TRANSLATIONAL RESEARCH AND
INNOVATIVE AND RECOVERY.
THE MAYOR COMES COME OUT IN THE
AMERICAN PSYCHIATRY AND THIS
DEFINITION OPERATIONAL
DEFINITION IS ALREADY STARTING
TO BE USED BY THE COMMUNITY AND
IN GRANT APPLICATIONS.
THE NEXT SLIDE, PLEASE.
AND THEN, WE HAVE NOTICES OF
SPECIAL INTEREST ISSUED BY
NIAAA, THE RESEARCH ON ALCOHOL
AND CORONAVIRUS, WITHIN THE
MISSION OF NIAAA AND THIS
INVITES GRANT APPLICATIONS IN
ADVANCE THE UNDERSTANDING OF THE
CRITICAL INCOMPETENTER ACTIONS
BETWEEN ALCOHOL USE AND
SARS-CoV-2, AND COVID-19.
A CENTRAL FOCUS IS RESEARCH THAT
KIM PROVE PUBLIC-HEALTH BY
INFORMING RESPONSES TO THE
EVOLVING COVID-19 PANDEMIC AND
IT'S CONSEQUENCES.
NEXT SLIDE.
WE JUST HAD AS OF YESTERDAY, A
WEBINAR AND THE RESEARCH SOCIETY
ON ALCOHOLISM AND SPEAKERS
INCLUDED ROBERT HEUGHN NER WHO
IS THE CHAIR OF FRIENDS OF NIAAA
AND IS A MYSELF AND CATHERINE KS
AND SPOKE ABOUT ALCOHOL
CONSUMPTION ABOUT OLDER ADULTS,
TRENDS AND SARAH JOE NIXSON A
BEHAVIORAL AND MAUD RAL ALCOHOL
CONSUMPTION IN OLDER ADULTS AND
FREDERICK BLOW ASSISTING OLDER
ADULTS WHO MISUSE ALCOHOL BRIEF
EVIDENCE BASED TREATMENT
APPROACHES AND THEY GAVE PAIN
AND ALCOHOL USE IMPLICATIONS FOR
HEALTHY AGING.
THIS WAS A VERY TIMELY WEBINAR.
IT WAS WELL ATTENDED AND JUST
OUTSTANDING TALKS SO FUTURE
FOCUS WITH THE INSTITUTE AND
WITH THE AGING POPULATION.
BABY BOOM GENERATION IS
BASICALLY REACHED 60 AND OLDER
AT ALL LEVELS AT THIS POINT.
SOL, I'M PROUD AND EXCITED AND
JUST OVERJOYED TO ANNOUNCE WE
ANNOUNCE WEHAVE ANNOUNCED THE HE
PROFESSIONALS CORE RESOURCE ON
ALCOHOL.
AND THE NEXT SLIDE.
WHAT IS THE SCORE RESOURCE ON
ALCOHOL.
MOST OF YOU KNOW BECAUSE THEY
KNOW IN HELPING US.
THE HEALTHCARE RO IS 14 ARTICLES
COVERING THE BASICS OF WHAT
EVERY HEALTHCARE PROFESSIONAL
NEEDS TO KNOW ABOUT ALCOHOL.
THE CORE QUOTE-UNQUOTE WAS
DEVELOPED BY NIAAA.
WITH GUIDANCE FROM PRACTICING
PHYSICIAN AND CLINICAL
PSYCHOLOGIST AND WE CREATED BUSY
CLINICIANS IN MIND AND THE CORE
ARTICLES PROVIDE USER-FRIENDLY
PRACTICAL OVER VIEWS OF THE
FOUNDATIONAL KNOWLEDGE FOR
UNDERSTANDING THE ALCOHOL
RELATED PROBLEMS FOR ARTICLES
AND THAT INCLUDES A SECTION ON
NEUROBIOLOGY AND A SECTION ON
WHAT IS A STANDARD DRINK ALL THE
WAY DO THE METABOLISM ALCOHOL
SECTIONS ON THE MEDICAL
COMPLICATIONS ASSOCIATED WITH
ALCOHOL AND THEN IF THE CLINICAL
IMPACTS OF ALCOHOL AND A LOT OF
INFORMATION ABOUT ALCOHOL
DISORDER AND MISUSE AND WHAT IT
CONSTITUTES AND STRATEGIES FOR
PREVENTION AND TREATMENT OF
ALCOHOL PROBLEMS AND A GOOD BIT
OF HOW YOU CAN ADOPT YOUR
PRACTICE TO HELPING PATIENTS AND
THEN HOW TO PUT IT ALL TOGETHER
AND PROMOTE PRACTICE CHANGES IN
PARTICULAR.
YOU KNOW, THIS IS AIMED AT THE
MEANING WOULD HAVE BEEN PRIMARY
CARE DOCTORS BUT WE HOPE THAT IT
WILL BE USEFUL FOR PHARMACISTS,
NURSE PRACTITIONERS, PHYSICIANS
ASSISTANCE, CLINICAL
PSYCHOLOGISTS AND EVEN BOARD
CERTIFIED ADDICTION MEDICINE
SPECIALISTS.
THE CORE ARTICLES ARE LIVING
DOCUMENTS AND THEM BE UPDATED
REGULARLY AND I EXPECT THAT YOU
ALL WILL FIND SOME ERRORS AND WE
WELCOME THAT INPUT AND I HOPE
ALL OF COUNCIL MEMBERS WILL LOOK
AT THIS CORE RESOURCE AND GIVE
US YOUR THOUGHTS.
WHO CAN RECEIVE CONTINUGEDUCATIS
FREE AND CONTINUING EDUCATION
CREDIT IS 0.75 AT ONE INTEREST
HOUR FOR EACH 14 ARTICLES THAT
ALMOST IS 11 CREDIT HOURS TOTAL
IT'S OFFERED FOR PHYSICIANS AND
PHYSICIANS ASSISTANCE AND NURSES
AND THIS IS A SPACE AS I
MENTIONED THE BASICS DEFINING
HOW MUCH ALCOHOL IS TOO MUCH AND
THERE'S A TAKEAWAY SECTION THAT
KIND OF SUMMARIZES EVERYTHING
AND IT GOES DOWN INTO THE
DETAILS AND ATED END YOU GET
REFERENCES AND HOW TO EARN CME
CREDIT.
THIS IS RECOVERY IT'S NOT A
MARATHON IT'S NOT A SPRINT.
THIS IS ONE OF THE LATEST ONES
AND THERE'S AGAIN TAKEAWAYS AND
RESOURCES, REFERENCES, AND HOW
TO EARN CREDIT.
SO, NEXT SLIDE.
I JUST WANT YOU TO REALIZE THIS
WAS AN ENORMOUS AMOUNT OF WORK
THAT WAS LED BY MAUREEN GARDNER
AND LAURA AND RAY AND I THINK
THEY SPENT THREE YEARS OF THEIR
LIFE ON THIS AND IT WAS
DEVELOPED WITH THE HELP OF MORE
THAN 70 CONTRIBUTORS INCLUDING
PHYSICIANS, CLINICAL
PSYCHOLOGISTS, BASIC AND
CLINICAL AND ALCOHOL RESEARCHERS
WHO SERVED AS WRITERS FOR FULL
ARTICLES AND CONTENT
CONTRIBUTORS TO SUBSECTIONS,
REVIEWERS AND EDITORIAL STAFF
AND THEY INCLUDED BOTH EXPERTS,
EXTERNAL TO NIAAA AS WELL AS
NIAAA STAFF AND SO YOU CAN SEE A
LISTING OF ALL THE PEOPLE WHO
HELPED AND I AM SO GRATEFUL TO
EVERY SINGLE ONE OF YOU.
THE NEXT SLIDE.
I'M GRATEFUL TO THE NIAAA TEAM
AND THE RAY LETTEN, LAURA AND
MAUREEN GARDNER REALLY PUT THEIR
HEART AND SOUL INTO THIS AND
EVERYONE ELSE ON NIAAA THAT YOU
CAN SEE IN THE LIST HERE HELPED
US AS WELL AND I'M REALLY
APPRECIATIVE AND SO WE THINK
THAT THIS IS A HUGE BIG DEAL AND
THIS IS ONE OF THE BIG IT'S THE
KNOWLEDGE AND CONVEYING OF THAT
KNOWLEDGE BY HEALTHCARE
PROVIDERS TO UNDERSTAND WHAT
ALCOHOL CAN AND IS DO TO THEM
AND I JUST FEEL STRONGLY THAT
THIS MAY NOT BE A BIG BOOM ON
THE HORIZON AS A GREAT EVENT BUT
AS IT GOES INTO THE COLLECTIVE
UNDERSTANDING OF ALCOHOL AND THE
ROLE IT PLAYS IN PATHO
PHYSIOLOGY AND HEALTHCARE COSTS
AND JUST GENERAL HEALTH, I THINK
IT'S GOING TO BE A GAME CHANGER.
NEXT SLIDE.
SO HERE IS THE LINK.
WE VALUE YOUR COMMENTS AND
PLEASE SEND THEM TO WE HOPE TO
TO BE ABLE TO UPDATE THIS AS WE
ALONG.
IT WAS WRITTEN IN A WAY THAT
THERE ARE SPECIFIC FACTS IN
THERE THAT THEY'RE DATED AND SO,
IT SHOULD NEW FACTS COME OUT AND
NEW STUDIES COME OUT THAT SUB
LAMENT OR VERIFY OR DISAGREE
WITH EARLY OBSERVATIONS THAT
WERE INCOMPLETE THEY'LL BE
FIXED.
THAT'S THE PLAN.
THE NEXT SLIDE.
SO NOW I'D LIKE IT TALK ABOUT
SOME RESEARCH HIGHLIGHTS.
I PICKED RESEARCH HIGHLIGHTS
THIS TIME THAT I THINK FOCUS ON
INDIVIDUAL DIFFERENCES ON EARLY
DIAGNOSIS AND EARLY TREATMENT
AND EARLY CHANGES IN THE BRAIN.
THAT OCCUR.
I'VE BEEN WORKING WITH NORAH
VOLKOFF AND TOM MA CELL MACLELLE
CALLS A PROCESS PRE ADDICTION
AND IT'S SOMETHING WOVE BEEN
WORKING ON IN THE ALCOHOL FIELD
FOR SOME TIME.
THE ARGUMENT WOULD BE THAT WE
FOCUS A LITTLE BIT TOO MUCH ON
SEVERE ALCOHOL USE DISORDER WHEN
IT COMES TO TREATMENT AND WE
REALLY NEED TO FOCUS ON EARLY
VUL NER A LOT.
VULNERABILITY.
THE EARLIER YOU ADDRESS THE
MENTAL HEALTH PROBLEM, WHETHER
IT'S SCHIZOPHRENIA OR DEPRESSION
OR AN ANXIETY DISORDER, OR
ALCOHOL USE DISORDER FOR THAT
MATTER, THAT THE BETTER THE
TREATMENT AND THE MORE
REMISSION.
SO, WITH THAT IN MIND, THAT'S
WHY I CHOSE THE ARTICLES I CHOSE
THIS TIME.
AND THE NEXT SLIDE.
BUT FIRST I WANT TO TALK ABOUT A
PAPER THAT AARON WHITE WHO IS A
SPECIAL ADVISER TO ME AND THE
OFFICE OF THE DIRECTOR OF NIAAA,
PUBLISHED IN THE JOURNAL OF THE
MEDICAL ASSOCIATION AND
COLLABORATION WITH RALPH AND
EJEN CASTLE AND MYSELF, AND IT'S
SHOWING SOMETHING THAT WE HAD
BEEN PICKING UP IN SOME VARIOUS
WAYS THAT DURING THE COVID-19
PANDEMIC THAT WHE WE WERE STARTG
TO SEE SOME PEOPLE DRINKING MORE
AND MAYBE THERE'S INCREMENTAL
PASSES AND AND ON DEATH
CERTIFICATES AND THE NUMBER AND
RATE OF ALCOHOL RELATED DEATHS
INCREASED 25% BETWEEN 2019 AND
2020 AND THE FIRST YEAR OF THE
COVID-19 PANDEMIC.
YOU KNOW, IT'S BEEN INCREASING
IN A SMALL PERCENTAGE AND I
MIGHT ADD THAT THESE ARE ABOVE
THOSE THAT YOU CAN ATTRIBUTE TO
COVID-19 THAT THE RATES INCREASE
FOR ALL AGE GROUPS WITH LARGEST
INCREASES OCCURRING FOR PEOPLE
AGE 35 TO 44 IN 25 TO 34.
AND THESE INCREASE IN DEATHS AND
REMAINED ELEVATED IN THE FIRST
HALF OF IT WILL LOOK SIMILAR TO
2020 BY THE DATA SO FAR.
THE REASON I INTRODUCED, THIS IS
THE FIRST SLIDE AND THE FIRST
RESEARCH ADVANCE HIGHLIGHT IS TO
REMIND YOU WHY WE'RE IN THIS
BUSINESS AND AS WE'VE SEEN
HISTORICALLY WITH STRESS EVENTS
LIKE 9/11 OR HURRICANE KATRINA
THERE'S BEEN AN INCREASE IN
ALCOHOL USE DISORDER AND IT
MEANS SOME OF THE THINGS I TOLD
YOU ABOUT THAT WE NEED TO
HIGHLIGHT, LIKE CLOSING THE
TREATMENT GAP, AND AGING
POPULATION ARE AREAS THAT WE ARE
GOING TO HAVE TO FOCUS ON AS WE
WIND DOWN FROM THIS PANDEMIC.
I WAS INTRIGUED BY THIS PAPER
FROM THE GROUP AT PURDUE
UNIVERSITY WHERE THEY TOOK AND
USED SERUM MA TAB A LOAM I CAN
ANALYSIS TO REVEAL SOLVE
METABOLITES IN ASSOCIATION WITH
EXCESSIVE ALCOHOL USE.
>> THEY ARE IN THE ORANGE LINES
AND I HOPE YOU CAN SEE THAT AND
THEY'RE COMPARED TO STANDARD BY
BIOMARKERS THAT ARE USED FROM
FROM TRANSFERASE TO CA CA CARBOE
AND MOST OF THE METABOLITES
IDENTIFIED WERE THE LIPID AND
THE PATHWAYS BOTH PATHWAYS THAT
ARE ASSOCIATED OF COURSE WITH
AND I CAN SEE THE ROC CURVES ARE
IMPROVED AND WHEN YOU GET TO A
POINT 8, THAT IS PRETTY GOOD.
WHEN YOU ARE COMPARING YOU KNOW,
THE TRUE POSITIVE RATE TO THE
FALSE POSITIVE RATE.
AND THE NEXT SLIDE.
AND THEN, YOU KNOW, MANY OF YOU
KNOW I HAVE A SOFT PART IN MY
HEART FOR A AND FULL DISCLOSURE
AND I WAS ON THE PART OF THE
GROUP AND I WAS A CONSULTANT FOR
THE COMPANY THAT SOUGHT APPROVAL
BY THE FDA AND LONG BEFORE I
JOINED NIAAA.
AND WE KNOW THAT IT'S AN
IMPROVED FDA MEDICATION FOR THE
TREATMENT OF ALCOHOL USE
DISORDER AND IT'S THOUGHT TO
REDUCE ALCOHOL CRAVING DURING
ABSTINENCE BUT PATIENTS VARY IN
THEIR TREATMENT RESPONSE TO
ACAMPROSATE AND THE VARIATIONS
TO EXPLAIN DISEASE IN THIS
PARTICULAR STUDY THEY WERE
LOOKING AT 267 PATIENTS AND THEY
REGLUE IT THAT CONTRIBUTE TO THE
PLASMA PROFILES ASSOCIATED WITH
CRAVING AND OR THE TREATMENT
OUTCOMES AND A SERIES OF GENES
WERE IDENTIFIED INCLUDING A
PROTEIN-PROTEIN INTERACTION AND
THE RECEPTORS D GENE AND YOU CAN
SEE THAT A NUMBER OF SNIPS IN
THIS GENE WERE ASSOCIATED WITH
TREATMENT OUTCOMES THAT IS IN
TABLE B THERE AND THEY'RE FOUR
SNIPS LISTED AND YOU CAN SEE A
DOUBLING OR TRIPLING OF WORSE
OUTCOMES ASSOCIATED WITH
ACAMPROSATE AND IF YOU TAKE THE
FIRST SNIP, YOU CAN SEE THE WILD
TYPE INDIVIDUALS YOU KNOW, WHO
WERE ABLE TO ABSTAIN FROM
ALCOHOL USE AND THE RED LINE,
BUT THE INDIVIDUALS WITH THIS
SNIP EITHER HOMO OR HETERO SIGH
GATES WERE SEWING A WORSE
RESPONSE TO A CAM PRO SATE.
THIS IS OUR TE DREAM WE HAVE
IDENTIFIES WHICH MEDICATIONS
WORKS AND WHICH PATIENTS.
THEY HAVE A LOT OF PATIENTS WHO
UTILIZE A CAM PRO SATE AND THIS
IS EXCITE TO GO PURSUE IN THE
FUTURE.
THIS WAS A STUDY AND AT
UNIVERSITY OF ILLINOIS IN
COLLABORATION WITH V V AND 12
WOMEN WITH SLEEVE GASTRECTOMY
WERE COMPARED TO NINE WOMEN
CONTROLS AND THE BARIATRIC
SURGERY IN THE LITERATURE IS
ASSOCIATED FIRST ANECDOTALLY AND
NOW IN STUDIES WITH HIGHER BLOOD
ALCOHOL CONCENTRATION AND HIGHER
BIOVAIL ABILITY OF ALCOHOL AND
HIGHER RISK OF ALCOHOL RELATED
CONSEQUENCES AND THEY
HYPOTHESIZED IN THE LITERATURE
THIS TO BE DUE TO DEFICITS IN
FIRST PASS METABOLISM OF ALCOHOL
SO TO BETTER UNDERSTAND HOW THE
STOMACH CONTRIBUTES TO FIRST
PASS METABOLISM, THE RESEARCHER
EXAMINED THE ALCOHOL AFTER
ALCOHOL ADMINISTRATION AMONG
WOMEN WITH SLEEVE GAS SEC TROM'
AND I THOUGHT IT WAS A DELIVER
STUDY BECAUSE THE LITERATURE IS
THAT THE FIRST PASS METABOLISM
THROUGH THE LIVER OR THE STOMACH
THAT IS AN IMPORTANT PART OF
ALCOHOL METABOLISM AND THE WOMEN
WITH THE GAS HE CAN THOME AND
THE HIGHER BASs SKATED THE
SUMMER CONTRIBUTE AND AND ALCOHL
RELATED CONSEQUENCES AND JUST SO
YOU KNOW, THESE INDIVIDUALS
RECEIVED THE EQUIVALENT OF 2.5
DRINKS.
IT WAS ABOUT .5 GRAMS PER
KILOGRAM AND I DID THE
CALCULATIONS IT WAS BASED ON
KILOGRAM OF NON FAT BODY MASS
AND I DID A QUICK CALCULATION
AND CAME UP WITH ABOUT 2.5
DRINKS WORTH OF ALCOHOL.
YOU CAN SEE THE BLOOD ALCOHOL
LEVEL WOULD REFLECT THAT.
AND THEN, MOVING TO THE CENTRAL
NERVOUS SYSTEM, I WAS INTRIGUED
BY THIS PAPER FROM THE ROBERTO
GROUP BY Dr. FLORENCE VERO
DIANNE AND THE REASON I WAS
INTRIGUED BECAUSE IT BROUGHT
BACK MEMORIES FROM MY OWN WORK
BUT ALSO A SOMEWHAT NEGLECTED
NEURO TRANSMITTER THAT WE KNOW
IMPACTS ON THE EXTENDED AMYGDALA
AND PLAYS A ROLE IN THE NEGATIVE
EMOTIONAL AND STRESS-LIKE
EFFECTS ASSOCIATED WITH ALCOHOL
USE DISORDER SO WE KNOW THAT THE
CENTRAL NUCLEUS OF THE AMYGLA
DEPENDS ON WHERE YOU CAME FROM
BUT THEY USED IN THIS PAPER NA
AS THE ACRONYM ARE BOTH INVOLVED
IN THE BRAIN'S RESPONSE TO
STRESS AND IN COLOMBIA AND THE
CURRENT STUDIES OF THE RESEARCH
INVESTIGATED HOW THE THE SYSTEM
REGULATES AND INFLUENCES
DRINKING BEHAVIOR IN ANIMAL
MODELS OF ALCOHOL USE DISORDER.
THEY FOUND THAT RECEPTORS ALPHA
1 AND BETA 1 POTENTIALLY GABBER
NEURO TRANSMISSION AND DROVE
ALCOHOL INTAKE AND THEY DID THE
OPPOSITE IN THE ANIMAL MODEL OF
ALCOHOL DEPENDENCE, BETA
RECEPTORS DIS INHIBITED A SUB
POPULATION OF CEA NEURONS AND
CONTRIBUTED TO ELEVATED ALCOHOL
INTAKE AND THEY FOUND --
(INAUDIBLE).
>> RALPH, YOU NEED TO MUTE.
POSTMORTEM HUMAN BRAIN TISSUE
AND REVEALED INCREASED ALPHA 1
RECEPTOR MRNA AND THESE ARE
POINTS SHOWN BELOW IN THE GRAPHS
BELOW BUT YOU CAN SEE ON THE
LEFT-HAND SIDE, IT DECREASED IPS
FREQUENCY AND HALF THE NEURONS
SUGGESTED A REDUCTION IN GAB A
RELEASE BUT AFTER 20 PRE
TREATMENT IT INCREASED AND IPSE
FREQUENCY AND FIVE OUT OF THE
EIGHT CELLS REVEALING RECEPTORS
RECRUITMENT IN INDEPENDENCE IN
THAT DIS TIN I OBJECT HOR WERE
BETA RECEPTORS AND YOU CAN SEE
THE INCREASE ON THE RIGHT-HAND
PART OF THAT PANEL F.
AND THEN, DECREASED SA
ELECTIVELY INTAKE OF ALCOHOL IN
DEPEDEPENDENT ANIMALS AND ALSO,U
CAN SEE IN THE HUMAN BEINGS IN
POSTMORTEM BRAIN TISSUE AN
INCREASE IN BETA RECEPTORS
EXPRESSION AND ALPHA 1 RECEPTOR
EXPRESSION IN THE AMYGDALA AND
THEY WORKED ON SHOWING THE T
COULD ALSO BLOCK NON DEPENDENT
DRINKING SO SUGGESTING THAT THE
SYSTEM MAY BE THE ALPHA AND IT
KICKS IN IN AN EARLY PART OF THE
TRANSITION TO ADDICTION AND THE
BETA SYSTEM MAY BE PART OF THIS
SUSTAINING OF THE ADDICTION
PROCESS IN THE SENSE OF NEURO
ADAPTATIONS IN THE SYSTEM SO
MOVING THE FIELD SIGNIFICANTLY
FORWARD IN THE AREA OF
NORADRENERGIC AS THE NEGATIVE
EMOTIONAL SIDE OF ADDICTION.
THIS WAS DONE AT YALE UNIVERSITY
AND BASICALLY THEY USED A REALLY
INTERESTING APPROACH TO LOOK AT
HIGH RISK DRINKERS AND THEY
DEFINED HIGH-RISK DRINKERS, AS
MANY OF THESE STUDIES I EXPLORED
FOR THIS ROUND OF RESEARCH
HIGHLIGHTS IS INDIVIDUALS WHO
DIDN'T DRINK PAST THE 14 FOR
MALES AND SEVEN PER WEEK FOR
SUPERVISED WHETHER CHANGES IN
OVER ALL STRESS RESPONSES CAN BE
AN EARLY MARKER OF MISUSE AND WE
WHO BINGED IN DRINKING AND THEY
THEN EXPOSED THEM TO A WHOLE
SERIES OF NEGATIVE
EMOTIONAL-TYPE PICTURES AND
IMAGE THEM DURING THIS AND SHOWS
DIFFERENCES IN STRESS RELATED
BRAIN NETWORKS THAT WERE
ACTIVATED IN THE RISKY DRINKERS
VERSUS THE LIGHT DRINKERS AND
STRESS WAS ASSOCIATED WITH A
VISUAL AND MOTOR NETWORKS IN THE
BINGE DRINKING GROUP ACTIVATION
OF VISUAL AND MOTOR NETWORKS IN
THE BINGE DRINKING GROUP AND THE
DOUGH FAULT MODE AND FRONTAL
NETWORKS IN THE LIGHT DRINKING
GROUP.
AND SO UNCOVER DIFFERENCES IN
NOW STRONGLY DIFFERENT EDGES
PREDICTED EMOTIONAL STRESS OF
VISUAL LESION APPROACH WAS USED
ALLOWING SUBSETS OF THE BRAIN TO
SERVE AS PREDICTORS AND THIS
REVEALED THE VISUAL NETWORKS
WERE SIGNIFICANTLY STRONGER
PREDICTERS OF EMOTIONAL STRESS
AND EDGES WERE CONNECTIONS
SELECTED ON EVERY LEV1 OUT FOLD
FOR ALL MODELS USED TO
UNDERSTAND THESE PREDICTIVE
NETWORKS.
SO, YOU KNOW, I DON'T REALLY --
TO BE HONEST WITH YOU,
UNDERSTAND HOW THEY DO THE
ANALYSIS OF THESE IMAGING BUT I
REEL THINK IT'S CLEVER TO LOOK
AT NETWORKS IN DO A VIRTUAL
LESIONING TECHNIQUE.
OF COURSE, I WOULD, GIVEN I
STARTED MY CAREER DOING LESIONS
ON RODENTS.
YOU CAN SEE HERE THAT A COUPLE
OF TAKE HOMES FOR ME WAS THAT
YOU KNOW, THEIR AWE IN THE
DISCUSSION THAT MAYBE THE
SEPTEMBER RAL MEDIAL PRE FRONTAL
CORTEX IS TAKING OFF LINE AND IT
MAKES SENSE SINCE THAT IS THE
NETWORK THAT CONTROLS THE
AMYGDALA THAT I TALKED ABOUT IN
THE PREVIOUS AND THE OTHER PARTI
WANT TO MENTION IS THINKING BACK
TO DAVE LOVINGER WORK WHERE THE
PART OF THE CORTEX COMES LINKED
INTO THE DORRAL LATERAL STRIDE
AND WHEN HABITS ARE FORMED AND
INDIVIDUALS GET INTO WHAT I CALL
PATHOLOGICAL HABITS OF DRINKING,
MAYBE THIS IS EARLY SIGN OF THAT
SO I'LL THROW THAT OUT FOR
FURTHER THOUGHT.
THE NEXT SLIDE, PLEASE.
THIS IS A VERY INTRIGUING STUDY
BY DUSTIN JAGGER.
AND INCLUDED CATHERINE KEYS WHO
PRESENTED YESTERDAY AND OUR
AGING SYMPOSIUM.
AND BASICALLY, WE'VE KNOWN FOR
SOME TIME, AND WE FOLLOWED THIS
CLOSELY THAT BINGE DRINKING AT
AGE 18 HAS BEEN SEEN
HISTORICALLY AND THERE'S ANOTHER
CHANGE THAT HAS BEEN OCCURRING
AND THAT HASN'T REALLY BEEN THAT
WELL STUDIED AND THAT IS THERE'S
A REVERSAL IN THE MID TO LATE
20s.
WITH AN INCREASE IN BINGE
DRINKING AND YOU CAN SEE THAT IN
THE GRAPH BELOW, ALL RIGHT.
SO YOU DON'T SEE THE DECREASE
BUT IF I SHOWED YOU ALL THE
YEARS BEFOREHAND, YOU WOULD HAVE
IN OTHER SLIDES IN THE PAST YOU
WOULD SEE THIS DECREASE IN BINGE
DRINKING AND UNDERAGE DRINKING
AND WE CAN TOUT THAT AS A
SUCCESS FOR MANY OF OUR
PREVENTION PROGRAMS.
THE CURRENT STUDY TOOK DATA FROM
MONITORING THE FUTURE FOR 30
YEARS, 30 YEARS, OK.
AND THEN THE RESEARCH IS FOUND
THAT THE REVERSAL OCCURRED
PRIMARILY BETWEEN THE AGES OF 18
TO 24 FOR THE MEN AND 18 TO 22
FOR THE WOMEN.
BUT WHAT WAS REALLY INTERESTING
IS THAT THE HISTORICAL NARROWING
IN THE GAP IN THE BINGE DRINKING
WAS MORE PRONOUNCED AT THE
BEGINNING THAN THE END OF THE
TRANSITION TO ADULTHOOD AND YOU
CAN SEE THAT IN THE GRAPH WHERE
THE GAP IS NARROWING TO THE
RECENT 1996 AND WOMEN TO 2006
AND WOMEN AND YOU MAY NOT BE
ABLE TO SEE IT BUT IT'S THE
SQUARE BOX AND THOSE ARE WHERE
THE LOWEST CONNECTION IS BETWEEN
THE MEN AND THE WOMEN AND WE'VE
BEEN SEEING THIS NARROWING OF
THE GAP AND IN WOMEN.
SO, WHAT IT DUE TO?
YOU KNOW, WELL, THEY DID SOME
SPECULATING AND IT'S NOT THE
MINIMUM DRINKING AGE BUT IT'S
MARRIAGE.
THERE'S A TABLE IN THIS PAPER
THAT SHOWS AS PEOPLE MARRIED
THEIR DRINKING WENT DOWN.
SO, YOU KNOW, I DO THINK AND
THAT BLIP YOU SEE, THE REVERSAL,
IS BEFORE THEY GOT MARRIED.
SO, SOMETHING TO THINK ABOUT AND
REALLY A FASCINATING ANALYSIS OF
DATA THAT IS OUT THERE TO
DESCRIBE WHERE WE MAY BE NEED TO
PUT ENERGY IN PREVENTION WHICH
IS IN THESE AGE GROUPS BETWEEN
18 TO 24 FOR MEN AND 18 TO 22
FOR WOMEN.
NEXT SLIDE.
SO, THAT IS ALL I WANTED TO
HIGHLIGHT THIS ROUND.
I WAS FASCINATED BY THESE
STUDIES.
I HOPE I DID THEM JUSTICE.
I WANT TO GIVE A SPECIAL THANKS
TO EVERYBODY THAT HE HELPED ME H
THIS.
CAR A. MARINE, PA TRISH A. KATE,
CAT, AARON, BRIGITTE, AND VAN
VAN.
AND FORECASTLY WANT TO GIVE
ACKNOWLEDGMENT TO TRISH POWELL
FOR HELPING ME FIGURE OUT THE
SNIPS AND AARON WHITE FOR
HELPING ME FIGURE OUT THE
EPIDEMIOLOGY AND BRIGITTE
WILLIAMS-SIMMONS FOR HELPING ME
FIGURE OUT EVERYTHING.
WE CAN MOVE TO DISCUSSION IF
THERE'S TIME.
I DON'T KNOW, ABE, DID I GO TOO
LONG AS USUAL?
>> WE ARE EARLY.
>> WOW!
>>
[LAUGHTER]
>> SO, WE HAVE EXTRA 15 MINUTES.
OK, SO I'LL SEE IF THERE'S
ANYTHING IN THE CHAT.
ALL RIGHT.
SO THE LINK TO THE NEW
HEALTHCARE PROFESSIONAL CORE
RESOURCE ON ALCOHOL IS IN THE
CHAT FROM BRIGITTE SO IF YOU
WANT TO DOWNLOAD THAT YOU CAN.
CHARLES IS REGARDING THE HC
PROVIDER RESOURCE WITH
CONTINUING EDUCATION CREDIT.
FANTASTIC IDEA.
AND I THINK HE MEANT TO SAY, I
DON'T KNOW WHAT ONE DONE MEANS
BUT I'M ASSUMING THAT'S GOOD
NEWS.
CAN I MENTION THE NAME CHANGE
FOR NIAAA.
KATIE, WANTS TO KNOW, THERE'S
NONAME CHANGE YET FOR NIAAA.
BRIGITTE, DO YOU WANT TO SPEAK
TO THAT PLEASE BECAUSE YOU ARE
FOLLOWING HOW THIS IS GOING TO
COME ABOUT.
>> YES, SURE.
SO, LAST TIME WE HAD TALKED
ABOUT IT YOU HAD GIVEN JUST A
BRIEF UPDATE ABOUT IT AND SO
THERE WAS A PROPOSAL FOR A NAME
CHANGE FOR NIAAA AND INCLUDED IN
PRESIDENT PROAL AND THE NAME
CHANGE MUST COME ACROSS, COME
THROUGH AN ACT OF CONGRESS SO
THE PROPOSAL HAS BEEN INCLUDED
AND THAT IS THE LATEST NEWS WITH
THAT.
>> WANT TO EMPHASIS IT BUT WE
JUST PROVIDED A SUGGESTION OF
WHAT IT COULD LOOK LIKE, ISN'T
THAT CORRECT?
THERE'S NO CODIFICATION OF ANY
SPECIFIC NAME?
>> ABSOLUTELY.
OUR NAME HAS NOT BEEN CHANGED.
IT'S CLEAR.
WE'RE STILL THE NATIONAL
INSTITUTE ON ALCOHOL ABUSE AND
ALCOHOLISM, A PROPOSAL HAS BEEN
INCLUDED IN THE PRESIDENT'S
BUDGET BUT NO CHANGE HAS BEEN
MADE.
>> SO, YOU KNOW, WE'LL KEEP YOU
POSTED AND YOU WILL BE THE FIRST
TO KNOW WHEN THINGS MOVE FORWARD
TO AN AREA WHERE WE NEED YOUR
INPUT.
SO I PROMISE YOU THAT.
AS DIRECTOR, ALL RIGHT.
BUT FOR THE MOMENT, THAT'S WHERE
WE'RE AT.
TUNE INTO CRAN AND SEE HOW NIADA
IS ADDRESSING THIS ISSUE AS WELL
BUT YOU WILL GET THE SAME
RESPONSE FROM THEM.
OTHER QUESTIONS OR COMMENTS?
ANY THOUGHTS ABOUT -- KATIE IS
THANKING US FOR OUR EFFORTS ON
THE DEVELOPMENT OF THE HPCR.
WE'RE STRUGGLING WITH THE
ACRONYM BUT I THINK HULE ART
PACKARD AND WHAT DO YOU USE TO
REMEMBER THE ACRONYM?
>> I SAY HPCR.
YEAH.
BUT HIGH PRESSURE -- YOU HAD
SOMEWAY.
>> THAT'S ALL I REMEMBER, I
DON'T KNOW WHAT THIS STANDS FOR
RIGHT NOW.
THAT'S HOW I REMEMBERED IT.
IT WAS THE HEALTHCARE
PROFESSIONAL CORE RESOURCE.
>> THANK YOU.
>> PULMONARY CHAIN REACTION.
HPCR.
I'LL TRYING TO HELP OUT HERE.
I'M OBVIOUSLY, DAVE LOVINGER
LIKES THAT.
[LAUGHTER]
HE WOULD.
SO, ANY OTHER THOUGHTS OR
COMMENTS?
PLEASE -- FEEL FREE.
WE HAVE A LITTLE TIME.
I DON'T KNOW HOW MUCH TIME WE
HAVE BECAUSE I HAVEN'T LOOKED AT
A CLOCK.
>> WE HAVE TIME FOR COUNCIL
DISCUSSION UNTIL 2:00.
>> ANYTHING ON THE MINDS OF
COUNCIL BEFORE YOU GET WORN-OUT
BIT REST OF COUNCIL?
AND WE PLAN ON WEARING YOU OUT.
BECAUSE WE HAVE SOME REALLY
EXCITING PRESENTATIONS COMING
UP.
ARE THERE ANY THOUGHTS.
>> I BIG YOU TO BE AMBASSADORS
FOR THIS AND WHAT WE DO.
YOU KNOW, I DON'T KNOW WHETHER
YOU REALIZE WHAT WE'VE
ACCOMPLISHED DURING THE PANDEMIC
AS I TOLD SOMEONE YESTERDAY, WE
HAVEN'T BEEN SITTING ON OUR
HANDS DURING THE PANDEMIC AND SO
YOU KNOW, AARON JUST PUBLISHED
THE PAPER ON THE DESK ASSOCIATED
WITH THE PANDEMIC AND WE HAD A
PAPER.
THE PAPER CAME OUT ON THE
RECOVERY DEFINITION AND THE
AMERICAN JOURNAL OF PSYCHIATRY
AND WE JUST LAUNCHED THE HPCR
AND THERE'S A PAPER COMING OUT
ON A PORTFOLIO ANALYSIS FROM MY
BELOVED HYPER AND BIOLOGICAL
PSYCHIATRY AND YOU KNOW, IF
THERE'S OTHER THINGS YOU THINK
WE SHOULD BE WORK ON, OTHER
THINGS WE SHOULD BE TRANSLATE TO
GO THE PUBLIC AND LET US KNOW
BUT YOU KNOW, I HOPE TO ENLIST
YOUR HELP, YOU COUNCIL MEMBERS,
ON GETTING THE WORD OUT ABOUT
THE HPCR AND ALSO CONTRIBUTING
IN ANYWAY THAT YOU THINK THAT WE
COULD CLOSE THIS TREATMENT GAP.
NANCY, WHO IS A CLINICIAN IN OUR
INTRAMURAL PROGRAM, AND I DON'T
KNOW, ARE YOU ON, NANCY IN ARE
YOU ON BY ANY CHANCE?
NANCY HAS TAKEN ON THE
LEADERSHIP TO SEE IF WE CAN
DEVELOP A CORE RESOURCE FOR
MEDICAL SCHOOLS BASED ON THE
HPCR BECAUSE HER CONTACTS WITH
YOUNG PEOPLE INDICATE THAT IT'S
JUST NEEDED IN MEDICAL SCHOOL,
FOR THEM TO UNDERSTAND YOU KNOW,
THE EVERYTHING ASSOCIATED WITH
ALCOHOL AND I HATE TO SAY THIS
BUT I JUST THINK THAT AMERICANS
NEED OBJECT BETTER INFORMED
ABOUT ALCOHOL EVERY LEVEL AND
NOT JUST IN THE HEALTH-CARE
SYSTEM BUT WE'LL START THERE.
GO AHEAD.
>> HI, I'M SORRY, I CAN'T FIND
MY LITTLE HAND THAT GOES UP.
>> THAT'S O. BETH.
OK, BETH.>> I AM JUST SO THANKFL
THIS BECAUSE I AM THE ONE ON
THIS PANEL THAT IS ACROSS THE
STREET DIRECTLY DOING THE
TREATMENT AND I CAN TELL YOU ONE
THING, WE ARE SEEING OLDER
PEOPLE COME IN FOR SUBSTANCE USE
DISORDER AND TREATING THEM VERY
SUCCESSFULLY.
SO THERE'S A SEAT CHANGE
HAPPENING WHERE NUMBER ONE, WE
ARE IDENTIFYING PEOPLE THAT WE
WEREN'T THAT GREAT AT
IDENTIFYING THEM AND REMOVE THE
STIGMA AND THEY'RE COMING IN FOR
THE EDUCATION.
WHICH LEADS ME TO PRODUCING SOME
FOR PROVIDERS AND I LOVE THE
IDEA OF MEDICAL STUDENTS AS WELL
BECAUSE THAT IS WHAT IS LACKING.
PEOPLE DON'T HAVE THE
INFORMATION TO ASK THE QUESTIONS
TO MAKE THE DIAGNOSIS TO SEND
PEOPLE ON TO TREATMENT.
THE TREATMENT LOCATER IS STILL
BEING USED, THAT'S REALLY
HELPFUL.
I THINK THIS TYPE OF INFORMATION
WILL HELP PEOPLE GET WHAT THEY
NEED AND GET THE TREATMENT THAT
WE ARE SEEING GOOD OUTCOMES WITH
AND SO THANK YOU FOR YOUR HARD
WORK, EVERYBODY.
>> SOMEONE WAS JUST SAYING, MAY
HAVE BEEN A PREVIOUS COUNCIL,
THAT WHEN YOU WALK INTO THE KNEE
SURGEON'S OFFICE THERE'S A BIG
POSTER OF YOUR KNEE AND WHAT IT
LOOKS LIKE AND WHERE YOU BROKE
IT AND WHAT NEEDS TO BE FIXED.
I THINK WE NEED TO HAVE SOME
EQUIVALENT FOR ALCOHOL MISUSE
AND ROW MIND ME, BRIGITTE, DOWN
THE LINE THAT I SAID THAT AND
DON'T CRINGE AT THE THOUGHT THAT
WE'RE GOING TO DO THIS.
[LAUGHTER]
BUT I DO THINK IT'S SOMETHING WE
SHOULD LOOK AT.
LAURA CAME NEXT WITH HER HAND
UP.
>> HI.
I'M JUST FASCINATED BY THE
BARIATRIC SURGERY FINDINGS.
I THINK THAT IS MIND BLOWING AND
WE HAVE BEGUN TO THINK ABOUT
THIS IN TERMS OF SMOKING AND ONE
OF THE PROBLEMS IS THAT YOU ARE
NOT SOMETIMES ALLOWED TO DO THAT
SURGERY IF YOU ARE A SMOKER AND
MY QUESTION, THAT'S MY COMMENT
SO I'M NOT SURE THAT WE WILL
HAVE CLEAR DATA WITH OTHER DRUGS
OF ABUSE GIVEN THE ELIMINATION
CRITERIA AND I WONDER IF THE
DATA IS VERY STRONG, YOU KNOW,
ARE WOMEN INFORMED OF THE RISK
WITH ABUSE TO.
>> THEY COUSINNED THAT IN THE
PAPER AND I DON'T KNOW WHETHER
HE IS ON BUT HE CAN COMMUNITY.
ARE YOU OUT THERE BY ANY CHANCE.
>> HE IS NOT.
I NEVER THOUGHT OF NICOTINE AND
IT'S INTERESTING AND I DON'T
KNOW WHERE I DON'T KNOW WHERE IT
IS AND I SHOULD ACTUALLY AND I
SHOULD BUT GOOD POINT.
BECAUSE IT'S AN APPETITE
SUPPRESS ENTER AND I MEAN, IT
COULD BE THE PERFECT DRUG BUT I
GUESS ALCOHOL IS JUST
FASCINATING THAT IS RAP KIN
RELATED BUT THAT WAS MY COMMENT
IF THEY KNOW IT'S A RISK FACTOR
NOW RIGHT.
>> I'M SURE HE WILL RESPOND.
CHRIS, DID YOU HAVE A COMMENT.
>> ONE IN RESPOND TO WHAT
LAWRENCE SAID AND I WAS AT RSA
AND I WENT TO A SYMPOSIUM ON
BARIATRIC SURGERY AND ONE OF THE
THINGS PEOPLE ASKED FOR IS COULD
WE GET RETHINKING DRINKING TO
LIST THAT AS ONE OF THE RISKS
AND COULD WE GET A WHOLE BUNCH
OF COPIES SO PEOPLE ARE AWARE
AND AT LEAST FROM SOME OF THE
SURGEONS THAT ARE GETTING ADVICE
AND THE OTHER COMMENT IS.
>> IT'S IN THE HPCR THERE WAS A
ONE-LINER IF THERE BUT I'M NOT
SURE.
>> STILL SOMETHING PEOPLE COME
INFORM SOMEWHERE THAN AN ALCOHOL
PROBLEM AND IT'S DEPECKED WHEN
THEY LOOK AT HEALTH PROBLEMS AND
IT TURNS OUT THE ALCOHOL SAY
MAJOR CONTRIBUTE OR AT LEAST
EXACERBATE PARTICULAR SO GETTING
THIS INTO THE HANDS OF SO MANY
CLINICIANS AND LETTING
CLINICIANS KNOW TO LOOK FOR THAT
IS REALLY IMPORTANT.
>> I'M GLAD, I DON'T KNOW
WHETHER YOU ALL REALIZE HOW WE
PICKED THE HIGHLIGHTS FOR THE
COUNCIL BUT IT COMES FROM THE
DIVISION DIRECTORS AND THEIR
STAFF AND EVERYBODY ON THE
DIVISION THAT THEY VOTE FOR WHAT
PAPERS APPEARED THAT ARE THE
COOLEST AND I GET TO CHOSE
SOUGHT OF THE ONCE THAT THEY
PICK AND SO I'M GLAD THAT THEY
PICKED THIS TIME AND IT WAS A
LOT OF FUN GOING THROUGH THEM.
>> YEAH, I WANTED TO STRESS THE
IMPORTANCE OF THE PURSES
TRAINING PROGRAMS AND MAKING
SURE THAT WE GET THIS NEW CORE
RESOURCE OVER TO HRSA SO THAT AS
THE POINTED OUT, AND WHETHER
IT'S FOR SURGERY IT'S FOR HYPER
TENSION OR THE CLINICIAN SHOULD
SCREEN FOR A SUBSTANCE USE ON
THE ROUTINE BASE ITS THAT'S AN
OUTSTANDING POINT WE HAD A
MEETING YESTERDAY WITH AND HAVE
YOU REACHED OUT TO HRSA YET SO I
JUST WROTE IT DOWN WE'LL DO THAT
AND IT'S A GOOD IDEA AND I THANK
YOU FOR THAT.
OTHER THOUGHTS OR COMMENTS.
NOW WE'RE AT TIME FOR OUR BREAK
BUT IF WE HAVE TIME FOR ONE MORE
IF SOMEBODY -- SO PAULIE JOSEPH,
DO YOU WANT TO ACTUALLY SAY
THIS?
SO JUST BECAUSE OF THE BARIATRIC
SURGERY COMMENTS BEING MADE.
SO ONE OF THE THINGS THAT AT
LEAST WE KNOW FROM THE CLINICAL
GROUPS IS THAT THERE'S A LOT OF
CHANGES IN TASTE AND SMELL AND
COLORRANCE FOR FOOD AND PATIENTS
THAT WE HAVE THE BARIATRIC
SURGERY IS THE SURGERY AND THERE
ARE MAPLE LEAFS HAVE BEEN
LOOK -- SO, THEY HAVE ADECREASIR
SWEET TASTING FOODS AND YOU SEE
AN INCREASE FOR ALCOHOL AND
WE'LL TALK ABOUT THIS LATER BUT
I THOUGHT I WOULD MENTION THIS
AS WELL.
>> VERY GOOD POINT AND VERY
INTERESTING, I CAN'T KNOW THAT
ABOUT THE CHANGES IN THEIR TASTE
AND SMELL AND COLORRANCE OF FOOD
SO THAT'S REALLY COOL SO.
I AM LOOKING FORWARD TO YOUR
TALK LATER WE ALL ARE.
ANY OTHER QUICK ONES.
OTHERWISE I'M GOING TO -- WORE
GOING TO TAKE A BREAK -- WE'RE
SUPPOSED TO DO IT AT 2:00.
SO WE'RE STILL 30 MINUTES AHEAD.
WHAT DO YOU WANT TO DO, ABE.
>> IF THERE ARE NO MORE
QUESTIONS WE CAN ACTUALLY TAKE A
30-MINUTE BREAK AND THEN WE WILL
COME BACK WITH THE AWARD.
>> WE'LL MOVE AWARD OF THIS DAY
SO ABE, IT'S MY FAULT BECAUSE I
TOLD ABE THAT WE SHOULD BUILD IN
AMPLE TIME FOR DISCUSSION AND
ALSO FOR BREAKS AND WE MAY HAVE
OVER DONE A LITTLE BIT BUT THEN
I RUN OVER ON MY TALKS AS WELL
SO, IN ANY EVENT, IT'S NOW:30
EAST TOAST TIME AND WE WILL
RECONVENE AT 2:00 EAST COST TIME
AND YOU HAVE TO TRANSLATE WHERE
YOU ARE, ALL RIGHT.
SO IT'S 1:30 EASTERN TIME AND
2:00.
YEAH.
>> OK.
SEE YOU ALL IN.
>>WE'RE BACK.
I HAVE A WONDERFUL NEXT ITEM ON
OUR LIST THAT IS ONE OF MY
FAVORITES OF ALL TIMES.
SO, I AM PLEASED THIS YEAR TO
PRESENT THE NIAAA'S SENATOR
HAROLD HUGHES MEMORIAL AWARD AND
TO Dr. CARLIE DECLEMENTE.
THIS AWARD RECOGNIZES THE
ACHIEVEMENTS OF AN INDIVIDUAL
WHO IS HELPED TRANSLATE RESEARCH
INTO PRACTICE AND IT WAS
CONTRIBUTE TODAY BRIDGING THE
ALCOHOL PREVENTION TREATMENT AND
POLICY MAKING COMMUNITIES.
THE AWARD COMMEMORATES THE U.S.
SENATOR HAROLD HUGHES WAS AN
INFLUENTIAL LEADER AND
SPEARHEADED POLICIES AND
PROGRAMS TO HELP THOSE EFFECTED
BY ALCOHOL MISUSE.
THE PUBLIC AGO MOM HAS PERSONAL
JOURNEY OF RECOVERY FROM ALCOHOL
PROBLEMS AND WAS A POWERFUL
ADVOCATE AGAINST THE DIG MA THAT
HINDERED ACCESS TO ALCOHOL
TREATMENT.
IT BROUGHT A SHIFT IN THE
ALCOHOL USE DISORDER IS NOT A
MORAL FAILING BUT A MEDICAL
CONTINUE TREATED EFFECTIVELY AND
ALSO CHAMPIONED FEDERAL SUPPORT
TO INVESTIGATE ALCOHOL IMPACT ON
HEALTH AND SOCIETY AND WAS THE
DRIVING FORCE BEHIND THE
CONGRESSIONAL ACT THAT BASICALLY
ESTABLISHED NIAAA IN 1970 SO WE
OWE A LOT TO HOWARD HUGHES AND
IN -- HAROLD HUGHES.
IN HIS HONOR, WE AWARD EVERY
YEAR A HUGHES AWARD FOR
RECOGNIZING THE ACHIEVEMENTS OF
AN INDIVIDUAL, AS I SAID, WHO
HELPED TRANSLATE RESEARCH INTO
PRACTICE AND WHO IS CONTRIBUTED
TO BRIDGING THE ALCOHOL
PREVENTION TREATMENT AND POLICY
IN COMMUNITIES.
I CAN'T THINK OF ANYONE WHO
DESERVES THIS MORE.
AS CO DEVELOPER OF THE TRANCE
THEORETICAL MODEL OF BEHAVIORAL
CHANGE, HE CONTRIBUTED
SIGNIFICANTLY TO A MORE
EFFECTIVE AND MORE COMPASSIONATE
APPROACH TO ASSIST PEOPLE IN
RECOVERY AND I'M JUST GOING TO
SAY THAT 40 YEARS AGO, I STARTED
TEACHING AT 9 UNIVERSITY OF
VALVE SAN DIEGO AND I STARTED
UNIVERSITY SAN DIEGO AND I
STARTED MOTIVATIONAL CHANGES
WENTING THE ADDICTIONS CYCLE AND
I REMEMBER WHEN I FINALLY MET
CARLO, I THOUGHT, MY GOODNESS,
HE IS SO YOUNG AND IT TELLS YOU
SOMETHING ABOUT HOW OLD I GUESS
WE'VE GOTTEN FINALLY BUT I WAS
THINKING WHEN I READ YOUR PAPERS
IT HAS TO BE SOME GRAY-HAIRED
GENTLEMAN WHO HAS BEEN AT THIS
FOR 100 YEARS AND IT TURNED OUT
IT WAS EARLY IN YOUR CAREER SO
IT WAS A REAL BREAK THROUGH.
HIS INSIGHTS ON AND THE
LONGSTANDING SIGMA ASSOCIATED
WITH ADDICTION AND THE IMPACT OF
Dr. DECLEMENTI WORK EXTEND
TODAY OTHER DISCIPLINES AND
LATER ON IN HIS CAREER SUCH AS
CANCER PREVENTION, DIETARY
CHANGE, HIV RISK, REDUCTION.
AND ARE STILL BEING UTILIZED AS
KEY COMPONENTS IN THOSE AREAS.
WHILE SERVING AS PROFESSOR IN
RESEARCHER AT THE UNIVERSITY OF
MARYLAND, BALTIMORE COUNTY,
Dr. KEY CLEMENT TEE CO CHAIRED
A NON-PROFIT ADVOCACY GROUP MADE
UP OF INDEPENDENT ORGANIZATIONS
WORK TO GO IMPROVE ALCOHOL
PREVENTION, TREATMENT AND
RECOVERY AND THIS IMPORTANT
ROLE, HE HELD TO RAISE AWARENESS
AND EDUCATE POLICYMAKERS AND
OTHER AUDIENCES ABOUT THE
PROGRESS AND PROMISES OF NIAAA'S
RESEARCH.
EVEN AFTER RETIREMENT HE
IMPROVED HEALTH AND POLICY.
HIS TIRELESS COMMITMENT HAS
CONTRIBUTED GREATLY TO THE
EFFECTIVE COALITION OF
HEALTHCARE PROFESSIONALS,
PREVENTION LEADERS, RESEARCHERS
AND POLICYMAKERS AND WE OWE A
DEBT OF GRATITUDE FOR HIS
LEADERSHIP AND VISION IN SUPPORT
OF NIAAA'S MISSION.
SO, CARLO, ON BEHALF OF NIAAA,
IT'S MY PLEASURE TO PRESENT YOU
TODAY WITH SENATOR HAROLD HUGHES
MEMORIAL AWARD, CONGRATULATIONS
AND SO WELL DESERVED.
[APPLAUSE]
YOU CAN SEE THE HANDS ARE GOING
UP.
>> I SEE HANDS THERE CLAPPING.
YES, THANK YOU, VERY MUCH.
>> AND 2 IF YOU'D LIKE TO SAY A
FEW WORDS.
YOU'VE HAD A STELLAR CAREER AND
WE'RE GRATEFUL FOR SUCH
STUPENDOUS SUPPORT OF THE
INSTITUTE.
SO AT LEAST DURING MY TENURE.
WHICH IS NOW EIGHT YEARS IF YOU
CAN BELIEVE IT.
>> YOU'VE BEEN THERE A WHILE,
YES, YOU HAVE.
>> YEAH, I JUST WANT TO THANK
YOU AND THANK ALL OF YOU FOR
THIS WONDERFUL RECOGNITION.
I MEAN, FROM MY DAYS IN HOUSTON,
DIRECTING AN ALCOHOLISM
TREATMENT CENTER AND ALCOHOL HAS
BEEN AT THE HEART OF A LOT OF
THE THINGS THAT I DO AND IT'S
BEEN WONDERFUL TO BE ABLE TO
PARTICIPATE IN SOME OF THE WORK
THAT NIAAA HAS DONE.
I AM ESPECIALLY PROUD OF KIND OF
GETTING FRIENDS OF NIAAA GOING
AND I WAS ENCOURAGED BY PETER
MONTE AND COLLABORATING WITH
JEFF AND WE PULLED TOGETHER
GROUPS.
YOU KNOW THAT FRIENDS OF NIAAA
IS NOT A INDIVIDUAL'S ART
MEMBERS THEY'RE ORGANIZATIONS.
SO THIS RECOGNITION REALLY GOES,
I THINK, INFO TO THE 35 DIFFERET
ORGANIZATIONS THAT HELPED US
CREATE IN ONE WAY OR ANOTHER
THIS COALITION THAT HAS BECOME,
I THINK AN IMPORTANT PIECE OF
HELPING WITH THE EDUCATION AND
THE SUPPORT FOR NIAAA AND THE
WONDERFUL WORK YOU ARE DOING.
I'M OLD ENOUGH TO REMEMBER THAT
THERE WAS A SENATOR, HAROLD
HUGHES FROM NEW JERSEY AND I'M
CERTAIN HE WOULD BE REALLY
PLEASED TO KNOW THAT THE WORK
THAT HE DID TO SUPPORT AND BUILD
THIS INSTITUTE, YOU KNOW, HAS
NOW FOR OVER 50 YEARS, HAS
HELPED CREATE SIGNIFICANT
SCIENCE AND RESEARCH AND POLICY
AROUND ALCOHOL SO IT'S REALLY
TERRIFIC.
SO I'M JUST HAPPY TO HAVE BEEN A
PART OF NIAAA'S EFFORTS TO
SUPPORT THE EMPIRICALLY BASED
INTERVENTIONS TO COMBAT STIGMA
AND TO CREATE A SYSTEM OF
PREVENTION AND CARE AND IT
REALLY RECOGNIZES THE NEEDS AND
MULTIPLE ISSUES THAT ARE THERE
WITH ALCOHOL BECAUSE I THINK
THAT'S REALLY THE BREATH OF
NIAAA IS REALLY STAGGERING IN
TERMS OF GOING FROM CELL TO
SOCIETY.
AND I THINK THAT IT'S REALLY
IMPORTANT WORK THAT YOU CONTINUE
TO DO.
BECAUSE, YOU KNOW, AS I KNOW
FROM TREATING FOLKS WITH THESE
PROBLEMS, EACH INDIVIDUAL HAS
UNIQUE NEEDS AND CHALLENGES AND
WHAT WE'RE TRYING TO DO IS
REALLY KIND OF ADDRESS THOSE IN
THE BEST WAY POSSIBLE AND NOT
ONLY FOR THE INDIVIDUAL BUT FOR
THE FAMILIES.
AND MANY OF THOSE FAMILIES ARE
OUR FAMILIES.
WE'VE HAD -- I HAVE HAD
INDIVIDUALS SUFFERING FROM
ALCOHOL PROBLEMS IN MY FAMILY.
SO, I WANT TO THANK YOU AND
STAFF AND COUNCIL FOR THE AWARD.
I DID RECEIVE THE PLAQUE OF THE
AWARD LAST WEEK IN THE MAIL SO
THANK YOU.
I'M FUMBLED AND APPRECIATIVE OF
THIS HONOR.
>> IT REALLY MEANS -- YOU'VE
DONE SO MUCH TO HELP THE FIELD.
I DON'T THINK I REMEMBER HAROLD
HUGHES AND I DID PUBLISH MY
FIRST PAPER IN 1970 AND SO I WAS
A GREAT WAD STUDENT BUT I DID
SEE THE VIDEOS AND SEEING HIM
BRING PEOPLE OUT TO THE PUBLIC
AND TALK ABOUT THESE PROBLEMS
THAT WHY SO COVERED NOT AND TO
CLOSE THE TREATMENT GAP WE MUST
THINK OF THE FAMILIES BECAUSE I
DOUBT THERE'S ANYONE ON THIS
ZOOM THAT DOES NOT HAVE A DOUBLE
NEGATIVE.
THAT DOES NOT HAVE A FAMILY
MEMBER TOUCHED BY ALCOHOL.
I CERTAINLY DO AS WELL.
DID AS WELL.
IT'S A PERVASIVE PROBLEM AND
YOU'VE DONE A LOT TO MOVE US IN
THE DIRECTION THAT WE'RE GOING
WHICH SAY GOOD ONE.
AS YOU KNOW, WE'VE BEEN SPENDING
A LOT OF TIME TRYING TO GET THE
KIND OF INFORMATION THAT YOU'VE
PROVIDED OUT TO THE PUBLIC AND
TODAY WE LAUNCHED THE HEALTH
PROFESSIONALS CORE RESOURCE.
YOU WILL FIND WHEN YOU GO
THROUGH IT, THERE'S A LOT OF THE
ELEMENTS OF YOUR FOUNDATIONAL
WORK IN THAT DOCUMENT SO.
>> THAT WAS A WONDERFUL -- I WAS
ON AND IT'S A WONDERFUL THING
AND I HOPE IT GETS DISSEMINATED
AND WE BUILD TRAINING PROGRAMS
AROUND SOME OF THAT MATERIAL FOR
THE PROVIDERS AND I THINK THAT'S
CRITICAL.
>>
>> IF AND WHEN WE SETTLE DOWN
AND THE PANDEMIC GOES AWAY, I
HOPE YOU WILL COME DOWN AND SEE
US AT ANY.
>> I'D BE GLAD TO.
>> OR WE'LL SEE YOU.
WE HAVE PLANS.
>> OK.
I'M IN.
>> GREAT TO SEE YOU.
>> SAME HERE.
TAKE CARE AND THANK YOU FOR ALL
OF YOU FOR YOUR WORK AND FOR
THIS HONOR.
THANK YOU, AGAIN.
>> CONGRATULATIONS AGAIN.
>> THANK YOU.
>> ALL RIGHT.
SO, THERE'S A LOT OF
CONGRATULATIONS IN THE CHAT.
CARLO, IF YOU WANT TO LOOK AT
THEM AND YOU WILL SEE WHAT WE'RE
DISCUSSING.
WHAT AM I DOING NEXT, ABE, IS
THIS TIME FOR Dr. CHRISTINA
CHAMBERS' TALK?
>> YES.
YOU CAN START SHARING YOUR
SLIDES, Dr. CHAMBERS.
>> I'M GOING TO DO AN
INTRODUCTION, CHRISTINA, YOU ARE
NOT GOING TO GET AWAY WITH
LAUNCHING RIGHT IN.
CHRISTINA WILL TALK ABOUT
EARLIER IDENTIFICATION OF
CHILDREN EFFECTED BY PRE-NATAL
ALCOHOL AND I WANT TO TELL YOU
ABOUT HER MANY OF SHE'S THE
PROFESSOR OF PEDIATRICS IN THE
SCHOOL OF MEDICINE AND THE
HERBERT WORT HYMN PUBLIC SCHOOL
OF SCIENCE AT THE UNIVERSITY OF
CALIFORNIA SAN DIEGO.
SHE'S VICE-CHAIR FOR CLINICAL
RESEARCH IN THE DEPARTMENT OF
PEDIATRICS AND CO DIRECTOR OF
THE UCSD CENTER FOR BETTER
BEGINNINGS.
Dr. CHAMBERS IS A PAST
PRESIDENT OF THE SOCIETY OF
BIRTH DEFECTS RESEARCH AND
PREVENTION AND ORGANIZATION OF
THE TER TOLL GEE INFORMATION
SPECIALIST.
Dr. CHAMBERS IS A PERINATAL
EPIDEMIOLOGIST WHOSE WELL FUNDED
RESEARCH FOCUSES ON ENVIRONMENT
ALEX POSE YOURS IN PREGNANCY AND
CHILD HEALTH OUTCOMES INCLUDING
BIRT DEFECTS AND SHE'S ONE OF
THE PRINCIPLE INVESTIGATORS AT
ANY INTERNATIONAL COLLABORATIVE
ATINTERNATIONAL FETAL ALCOHOL AD
TREATMENT OF DISORDER AND Dr.
CHAMBERS IS ONE OF THE PRINCIPLE
INVESTIGATORS ON NIAAA
COLLABORATION ON FASD PREVALENCE
THAT WAS KNOWN POFAS.
AND IN THE UKRAINE AND SOUTH
AFRICA AND Dr. CHAMBERS AS 245
PEER REVIEWED RESEARCH
PUBLICATION AND HER RESEARCH
ACTIVITIES INCLUDE COHORT
STUDIES EVALUATING THE IMPACT OF
MATERNAL DISEASE AND TREATMENTS
IN PREGNANCY AND LACTATION AND
INCLUDING COVID-19 IN COVID-19
VACCINES AND SHE'S CURRENTLY THE
PRINCIPLE INVESTIGATOR OF THE
COORDINATING CENTER FOR THE
HEALTHY, NOT HEAL, HEALTHY BRAIN
AND CHILD DEVELOPMENTS STUDY
THAT WE'RE PARTICIPATING IN AND
THAT STUDY IS UNDERWAY AND Dr.
CHAMBERS WAS CONTINUOUS LOW
FUNDED BY NIAAA, NAIDA AND THE
NATIONAL INSTITUTE ON CHILD
HEALTH AND DEVELOPMENT AND SO,
YOU KNOW, Dr. CHAMBERS IS
REALLY ONE OF THE FOREMOST
PEOPLE WORKING IN THIS
DEVELOPMENTAL AREA IN THE WORLD
AND WE HIGHLY VU VALUE HER WORKD
HER COLLABORATION AND LEADERSHIP
IN PARTICULAR.
SO, Dr. CHAMBERS, I TURN IT
OVER TO YOU.
>> THANK YOU SO MUCH, GEORGE.
I APPRECIATE IT.
ALL RIGHT.
LET'S SEE IF WE CAN MAKE THIS
COME UP HERE.
ARE WE GOOD TO GO?
HOPEFULLY EVERYBODY CAN SEE
THIS?
>> YES, WE CAN.
>> SO AS GEORGE SAID, I'M TRYING
TO GIVE YOU A OVER VIEW OF WORK
WE'VE BEEN DOING, MYSELF AND
REALLY THE TEAM.
I WORK WITH AN EASTERLY YEAR
IDENTIFICATION OF CHILDREN
EFFECAFFECTED BY PRE-NATAL ALCO.
THEY ARE COMMON WORLDWIDE AND
PROBABLY THE BIGGEST KNOWN CAUSE
OF DEVELOPMENTAL DISABILITIES IN
A REVIEW PUBLISHED BY SYLVIA
RUSEN AND COLLEAGUES A FEW YEARS
AGO, LOOKING AT DATA FROM 10
COUNTRIES, SHE CAME UP WITH A
PREVALENT ESTIMATE OF 2.3 AND AS
GORGE MENTIONED, PHIL MAY AND I
WITH NIAAA OPPORTUNITYING
COMPLETE AID STUDY A FEW YEARS
AGO DOING A ESTIMATE FOR FETAL
ALCOHOL SPECTRUM DISORDERS IN
FOUR U.S. COMMUNITIES TO
ESTABLISH A CIT ABLE ESTIMATE OF
THE DISORDER IN THE U.S.
WHAT WE CAME UP IN THE FIRST
GRADE IN SCHOOL, IN THE GENERAL
POPULATION IN THESE FOUR
COMMUNITIES, WAS AN ESTIMATE OF
1.1 TO 5% AND THAT WAS USING THE
MOST CONSERVATIVE ESTIMATES, THE
TRUE ESTIMATE IS PROBABLY
HIGHER.
IMPORTANTLY, IN THAT STUDY,
FEWER THAN 1% OF 222 CHILDREN
WHO ARE IDENTIFIED AS HAVING AN
FASD ACROSS THE FOUR
COMMUNITIES, HAD HAD A PREVIOUS
FASD DIAGNOSIS AND SO SUGGESTING
AS HAS BEEN STATED IN A SMALLER
SCALE BEFORE THAT THERE'S
WIDESPREAD UNDER RECOGNITION OF
THE DISORDER WITH MISSED
OPPORTUNITIES FOR INTERVENTION.
SO, FASD REMAINS A MAJOR
PUBLIC-HEALTH CHALLENGE FOR
PREVENTION AND IN MY OPINION, AT
LEAST IN MY LIFETIME, IT'S
UNLIKELY THAT FASD WILL BE
PREVENTED.
SO THERE'S A DIRE NEED FOR
METHODS THAT WILL WORK TO
IDENTIFY WHO IS MORE LIKELY TO
HAVE AN EFFEC AFFECTED CHILD ORH
CHILD WILL BE AFFECTED IN LIFE
SO THAT APPROPRIATE
INTERVENTIONS CAN BE INITIATED
AT THE TIME THEY'RE LIKELY TO
HAVE THE MOST BENEFIT.
SO THE WORK I'M GOING TO
DESCRIBE AS GEORGE MENTIONED, IS
PART OF THE COLLABORATIVE
INITIATIVE ON FETAL ALCOHOL
SPECTRUM DISORDERS THAT IS A
CONSORTIUM THAT'S BEEN
CONTINUOUSLY FUNDED FOR FOUR
ROUNDS BY NIAAA.
LED BY Dr. ED RILEY AT SAN
DIEGO STATE UNIVERSITY AND
INVOLVING MULTI-DISCIPLINARY
RESEARCHERS SHOWN HERE.
THE LAST TIME WE MET IN-PERSON
IN SAN DIEGO, WHO ARE FOCUSED ON
TRYING TO DIAGNOSE, TREAT AND
PROVIDE INTERVENTIONS FOR THIS
DISORDER.
AND THE CLINICAL PROJECT THAT
I'VE RUN IS PART OF CIFASD WITH
A TEAM OF INVESTIGATORS WHO ARE
AMAZING, HAS BEEN FOCUSED IN TWO
STATES IN UKRAINE.
SHEEN HERE ON THE UPPER LEFT
EAST OF KYIV.
EACH HAS 250,000 RESIDENTS AND
PROBABLY UNKNOWN TO EVERYBODY IN
THE ROOM UNTIL THE LAST COUPLE
MONTHS AND NOW THESE NAMES SEEM
TO BE MORE FAMILIAR TO PEOPLE.
SO, WHAT WE HAVE INITIATED IN
2007, AND HAVE CONTINUED TO
TODAY, IS THAT PROSPECTIVE
COHORT STUDY OF PREGNANCIES AND
THEN THE OFFSPRING OF THOSE
CHILDREN, I MEAN OF THOSE
PREGNANT WOMEN, IT'S A
COLLABORATION WITH NON-PROFIT
CALLED THE OMNI NET CENTERS IN
UKRAINE WHICH IS A EDUCATIONAL
AND PARENT SUPPORT GROUP FOR
FAMILIES OF CHILDREN WITH BIRTH
DEFECTS AND LVIV NATIONAL
MEDICAL UNIVERSITY.
AND IT'S LED BY A MEDICAL
GENETICIST, AND A GENETICIST AT
THE OTHER LOCATION.
AND SO AT THE DIAGNOSTIC CENTER
AND THE REGIONAL PERINATAL
CENTER AND THE TWO SITES
SCREENED THEY INVITED WOMEN WHO
REPORTED WHAT WE CLASSIFIED AS
MODERATE TO HEAVY EXPOSURE IN
PREGNANCY AND DEFINED AS
SOMEWHERE BETWEEN 10 AND 20 OR
MORE STANDARD DRINKS AND THE
MONTH AROUND CONCEPTION AND OR
THE MOST RECENT MONTH WHICH WAS
TYPICALLY THE SECOND TRIMESTER
AND ALSO RECRUITED A COMPARISON
GROUP OF LOW UNEXPOSED WOMEN WHO
REPORTED FEWER THAN TWO
STANDARDS DRINKS IN ANY WEEK IN
THE MONTH AROUND CONCEPTION AND
NO ALCOHOL IN THE MOST RECENT
MONTHS OF MID GESTATION.
AND, THEY WERE ENROLLED IN A ONE
TO ONE RATIO WITH PREFERENTIAL
MATCHING ON TOBACCO USE.
TO GIVE YOU AN IDEA ABOUT
PATTERNS OF USE IN THIS GENERAL
POPULATION OF PREGNANT PERSONS,
AND THE FIRST AND PREGNANT WOMAN
AND AND THE SECOND TRIMESTER AND
IN THE U.S. AND IN AN ANSWER TO
THE QUESTION ABOUT THE TOTAL
NUMBER OF DRINKS SHE CAN HOLD,
ON AN OCCASION, 36% SAID THREE
OR FOUR AND 17 SAID FIVE OR
MORE.
SO IN TERMS OF DATA COLLECTION,
OVER THE COURSE OF THE COHORT
STUDY WE'VE DONE TWO MATERNAL
INTERVIEWS IN ENROLLMENT AND THE
THIRD TRIMESTER THE ROUTINE
ULTRASOUND DATA HAS BEEN
COLLECTED AND SOME ADDITIONAL
MEASURE AND AND BLOOD, SA LIE VA
AND BREAST MILK AND SO ON AND WE
ESTABLISHED . REPOSITORY AT UC
SAN DIEGO WHERE THOSE SAMPLES
RESIDE.
IF PREGNANCY ENDS WITH A LIVE
BORN BABY OF ONE OR MORE THERE'S
A STUDY RELATED WITH POLICY
EXAMINATION AND LED BY Dr.
KENNETH JONES THE HEAD OF THE
CORE FOR THE CONSORTIUM AND
TRAINED AND LOOK AT THESE
CHILDREN FOR PHYSICAL FEATURES
OF FASD AND GROWTH AND THERE'S
STANDARD NEURO BEHAVIORAL
TESTING ASSESSMENTS THAT TAKE
POLICE IN INFANCY THAT BAILEY
SCALES HAS BEEN IN DEVELOPMENT
AND SIX AND 12 MONTHS AND
PRESCHOOL TESTING BATTERY AND
SCHOOL-AGE TESTING BATTERY AND
THEY HAVE BEEN COLLECTED FROM
CHILDREN, SALIVA AND SKIN SWABS,
BLOOD WHERE WE CAN GET IT AND
THAT'S BEEN THE MORE DIFFICULT
ONE TO CAPTURE FROM CHILDREN.
AND THEN, AT ONE SITE, WE'VE HAD
A 3-D CAMERA, WE'VE BEEN
CAPTURING 3D FACIAL IMAGES OF
THESE CHILDREN AND OF ANOTHER
CONSORTIUM AND HE HAS BEEN
EVALUATING THOSE.
SO THE FOUR QUESTIONS I WANT TO
BRIEFLY GO OVER THAT ARE
INVOLVED OTHER INVESTIGATORS ON
THIS PROJECT AND THE GREAT WORK
THAT THEY'VE DONE, REGARDING --
ARE FIRST CAN ROUTINE 2D
PRE-NATAL ULTRASOUND BE USED TO
IDENTIFY A PHYSICAL FEATURE OF
EFFECTED INFANTS BEFORE BIRTH
WITH OR WITHOUT A PRIOR
KNOWLEDGE OF PRE-NATAL ALCOHOL
EXPOSURE.
SECONDLY, DO TRAJECTORIES AND
I'LL TALK ABOUT THIS IN A WAY.
A WAY OF CHARACTERIZING PATTERNS
OF ALCOHOL USE ACROSS GESTATION,
ARE THEY A METHOD THAT IS USEFUL
IN TERMS OF PREDICTING NEURO
BEHAVIORAL OUTCOMES AS WELL AS
OTHER OUTCOMES AND CAN THEY BE
USED TO IDENTIFY CHILDREN WHO
WILL GO ON TO EXHIBIT
DEVELOPMENTAL DEFICITS THAT WE
TYPICALLY WOULDN'T RECOGNIZE
UNTIL THE CHILDREN ARE MUCH
OLDER THIS IS ANALYSIS THAT WAS
DONE BY OUR GROUP ALCOHOL
RESEARCHER AND WE ADDED TO THE
ROUTINE PRE-NATAL YOU WILL EXTRA
ULTRASOUNDSAND THAT THE ULTRA-SR
ADDED ADDITIONAL MEASURES IN THE
FIRST PANEL.
YOU CAN SEE A MEASURE OF THE DIE
AM FER AND IN THE SECOND ONE
DISTANCE AND IN FRONT OF HALAMIC
DISTANCE AND OUTER AND INNER
ORBITAL DISTANCE AND DIE AM NER
AND AS ADDITIONAL MEASURES
ASSOCIATED WITH IDENTIFYING
EFFECTS OF ALCOHOL AND SO, IN
THIS ANALYSIS AMONG 233
PORT-CHILD PAIRS, WHAT Dr.
MONTAG DID WAS LOOK AT THOSE WHO
WERE ULTIMATELY CLASSIFIED AS
FASD VERSUS THOSE WHO WEREN'T TO
SEE IF THESE PRE-NATAL
DIAGNOSTIC MARKERS MIGHT DIFFER
AND SHE DID FIND DIFFERENCES ON
INTER ORBITAL DISTANCE AND
DIFFERENCES ON RATIO MEASURES
OVER INTER ORBITAL DISTANCE AND
SO ON WHERE THERE WAS
SIGNIFICANT DIFFERENCES AND SHE
ALSO FOUND SIGNIFICANT
DIFFERENCES STRATIFYING HAVING A
BAILEY SCORE ONE STANDARD
DEVIATION BELOW THE MEAN RATHER
THAN THOSE WHO HAD A SCORE ABOVE
THAT ON SHORTER DISTANCE AND
LONGER IOD DISTANCE AND RARE YO
MEASURES BUT THE BOTTOM LINE WAS
THE ULTRASOUND VARIABLES ALONE,
TAKEN AS A GROUP OR
INDIVIDUALLY, PREDICTED LESS
THAN 10% OF THE VARIANTS IN ANY
OF THE FASD OUTCOMES THAT'S WE
LOOKED AT WITH THE ADDITIONAL
ALCOHOL, WE CAN GET IT UP TO
ABOUT 30% BUT WE CONCLUDED THAT
ULTRASOUND VARIABLES ALONE AT
LEAST THE ONES WE CAPTURED WERE
NOT LIKELY TO BE A STAND ALONE
WAY OF SCREENING FOR CHILDREN
WHO WOULD BE CLASSIFIED AS
EFFECTIVE.
SO THE NEXT QUESTION WAS ABOUT
TRAJECTORIES AND THIS IS WORK
THAT'S BEEN DONE BY GRETCHEN IN
OUR GROUP.
NEW INVESTIGATOR AWARDEE WITH
NIAAA.
AND WHAT SHE'S DONE IS USED A
TECHNIQUE, STATISTICAL TECHNIQUE
TO GROUP PAT PERSONS OF USE BY
LIGHT CLUSTERS AND SO IN 471
WOMEN WHO REPORTED DAY BY DAY,
ALCOHOL USE IN PREGNANCY WHAT
SHE DID WAS CLASSIFY THEM INTO
THESE FIVE TRAJECTORIES BASED ON
HOW THEY CLUSTER SO YOU CAN SEE
THE BLACK FINE IS THE NO EXPOSED
AND TRAJECTORY B THE GREEN LINE
OF DRINKING ABOUT A DRINK A DAY
BUT QUIT WHEN THEY FOUND OUT
THEY WERE PREGNANT, TRAJECTORY C
IN THE DARK BLUE, DRINKING ABOUT
A DRINK A DAY BUT DIDN'T REDUCE
MUCH WHEN THEY FOUND OUT THEY
WERE PREGNANT AND THEN
TRAJECTORY D, DRINKING MORE LIKE
TWO OR THREE DRINKS A DAY UNTIL
RECOGNITION OF PREGNANCY AND
REDUCED TO A SIMILAR LEVEL TO
THE C AND E IN THE LIGHT BLUE,
PEOPLE DRINKING SUBSTANTIAL
AMOUNTS AND CONTINUE THROUGH OUT
PREGNANCY.
LOOKING AT ONE OF THE OUTCOMES,
WHICH IS PERFORMANCE ON THE
BAILEY SCALES AS SHOWN IN THIS
GRAPH AT SIX MONTHS AND 12
MONTHS OF AGE.
AS EXPECTED, IN THE LIGHT
BLUE-LINE, LARGEST DEFICIT IN
PERFORMANCE WAS SEEN IN
TRAJECTORY E WITH HIGH SUSTAINED
USE AND TRAJECTORY B IN GREEN,
DEMONSTRATED NON SIGNIFICANT
DIFFERENCES AMONG THOSE WOMEN
WHO AVERAGED ABOUT A DRINK A DAY
UNTIL PREGNANCY RECOGNITION AND
THEN DISCONTINUED.
AND INTERESTINGLY, SHE SAW
MODEST BUT SOMEWHAT SIMILAR
DIFFERENCES IN BOTH TRAJECTORY C
AND THE DARK BLUE-LINE AND
TRAJECTORY D IN THE RED.
SO REMEMBER TRAJECTORY D STARTED
OUT WITH MUCH HIGHER CONSUMPTION
THAN C BUT BOTH CONTINUED AFTER
RECOGNITION WITH LOW LEVELS OF
CONSUMPTION THROUGHOUT THE REST
OF PREGNANCY SO SUGGESTING THAT
THE CONTINUED USE IS IMPORTANT
IN THIS OUTCOME.
AND THEN MOVING ON TO
BIOMARKERS, Dr. MIRANDA, WHO
HAS BEEN A LEADER IN THIS FIELD
AT TEXAS A&M, WE'RE SO LUCKY TO
HAVE HIM AS A COLLABORATE ERR ON
THIS STUDY AND HIS RESEARCH
SCIENTIST HAVE BEEN LOOK AT
CIRCULATING MICRO RNAs IN MA
TERNE AT PLASMA IN PREGNANCY AS
. MARKER FOR AN EFFEC AN AFFECT.
THEY'RE NON PROTEIN CODING RNA
MOLECULES WITH PROTEIN
TRANSLATION AND SHOWN TO BE
SENSITIVE TO ALCOHOL AND TO
MEDIATE ALCOHOL EFFECTS IN
ANIMAL MODELS.
AND SO, WHAT THIS GROUP HAS DONE
IS EXAMINED DIFFERENTIAL
EXPRESSION OF MICRO RNA IN
PLASMA AND THE SECOND AND THIRD
TRIMESTER OF PREGNANCY AND WE
DID IT USING A CASE CONTROL
DESIGN FOR WHICH WE HAD COMPLETE
DATA AND SAMPLES SO A GROUP THAT
WAS UNEXPOSED, A GROUP THAT WAS
MODERATE TO HEAVILY EXPOSED AND
THE CHILD WAS APPARENTLY
UNAFFECTED SO AND THEN A GROUP
THAT WAS EXPOSED BUT THE CHILD
WAS EFFECTED SO THEY HAD
PHYSICAL FEATURES AND NEURAL
BEHAVIORAL IMPAIRMENT AND HERE
THE RESULTS FOR THE INITIAL
ANALYSIS LOOKING AT SEVERAL
HUNDRED MICRO RNAs 11 THAT
CAME TO THE SURFACE AS BEING
DIFFERENTIAL LOW EXPRESSED AND
PARTICULARLY IN THE HEAVY
EXPOSED GROUPS.
IN THE HEAT MAP, MID AND LIGHT
PREGNANCY SAMPLES THAT THE
EXPRESSION PATTERNS FOR THESE 11
MICRO RNAs WERE DIFFERENT THAN
THOSE GROUPS THAT WERE HEAVILY
EXPOSED BUT THE CHILD WAS
APPARENTLY UNAFFECTED OR THE
UNEXPOSED GROUP WITH PROBABLY
THE MID PREGNANCY SAMPLES BEING
THE MORE INFORMATIVE.
I'M NOT GOING TO HAVE TIME TO
TALK ABOUT THIS BUT ANOTHER
REALLY INTERESTING ANALYSIS OF
THESE DATA WAS DONE BY A STUDENT
IN Dr. MIRANDA'S GROUP LOOKING
AT BOOTSTRAP TECHNIQUES TO LOOK
AT SEX DIFFERENCES AND SHE WAS
ABLE TO AT LEAST STRUCK THIS
DATA THAT MATERNAL CO SECRETION
OF MICRO RNAs WAS DIFFERENT
PREFERENTIALLY IN MOTHERS
CARRYING FEMALE FEE USES AND
THOSE FEMALE FETUSES WERE MORE
LIKELY TO BE AFFECTED.
WHAT MIGHT BE THE MECHANISMS
INVOLVED IN THIS?
WELL ONE PROPOSED MECHANISM IS
THE EFFECTIVE ALCOHOL AND
PLACENTA FUNCTION AND MIKE RE
RNAs MAY PLAY A ROLE IN THIS
SO Dr. ALEX ZHANG ASKED
WHETHER THEY MIGHT CONTRIBUTE TO
THE PATHOLOGY OF PRE-NATAL
ALCOHOL BY INHIBITING TRANSITION
OR EMT AND IT'S A PATHWAY
INVOLVED IN PLACENTAL
DEVELOPMENT AND KNOWN TO BE
AFFECTED BY PRE-NATAL ALCOHOL
EXPOSURE IN RODENTS AND PRIMATES
SO HE TOOK THOSE 11 MICRO RNAs
THAT WERE IDENTIFIED IN THE
MATERNAL ANALYSIS AND DID A
EXPERIMENTAL STUDY WHERE HE GAVE
THOSE 11 MICRO RNAs TO THE
PREGNANT MOUSE AND COMPARISON
GROUP WHO DIDN'T GET THE MICRO
RNAs AND LOOKED AT OUTCOMES
FOR THE PUPS AND SO HE FOUND
REDUCED, THIS IS A DIAMETER AND
REDUCED BY PER ATAL AND REDUCED
FETAL WEIGHT IN THE PUPS BORN TO
THE MOM WHO RECEIVED THE MICRO
RNAs PRE-NATALLY AND
IMPORTANTLY, HE DETERMINED THAT
IT WAS THE 11 IDENTIFIED MICRO
RNAs COLLECTIVELY BUT NOT
INDIVIDUALLY THAT RESULTED IN
THESE FINDINGS AND HE ALSO
DEMONSTRATED SEPARATELY THESE 11
MICRO RNAs MEDIATED PLACENTAL
EMT IN THAT MOUSE MODEL SO A
POTENTIAL MECHANISM AND ALSO
SUGGEST A POTENTIAL INTERVENTION
TARGET.
AND THEN LOOKING AT CHILDREN,
SAMPLE SIZES ARE STILL SMALL
HERE AND THIS IS NOT YET
COMPLETED BUT Dr. MIRANDA
LOOKED AT 57 CHILDREN FROM THE
UKRAINE COHORT FOR WHICH WE HAD
PLASMA SAMPLES AND LOOKED
ANOTHER DIFFERENTIAL EXPRESSION
OF MICRO RNAs ON THE LEFT AND
THEY WERE ASSOCIATED WITH BEING
MORE HIGHLY EXPRESSED IN
CHILDREN WHO WERE PRE-NATALLY
EXPOSED TO THE GROWN DOTS AND GD
ORANGE DOTS AND HE LOOKED AT
THOSE WHO WERE MODERATE TO LARGE
INCREASES IN EXPRESSION
ASSOCIATED WITH HAVING A CHILD
WHO HAD NEURO DEVELOPMENTAL
DELAY.
AND IMPORTANTLY, OF THE NINE OF
THOSE MICRO RNAs THAT WERE
DIS-REGULATED, IN CHILDREN WHO
ARE NEURO DEVELOPMENTAL DELAY
THOSE WERE AMONG THE SAME NINE
OF THE 11 SEEN IN THE MATERNAL
SAMPLES THAT PREDICTED ADVERSE
OUTCOMES FOR THESE CHILDREN SO
SUGGESTING SOME SORT OF
CONTINUITY THE SECOND IS IN
COLLABORATION AT THE UNIVERSITY
OF NEWFOUNDLAND AND WHO LOOKED
AT IMMUNE NETWORKS AND REGULAR
SEE AS A POTENTIAL BIOMARKER AND
SO HERE IS HERE DIVIDED INTO
FOUR GROUPS AND THE TOP TWO ARE
UNEXPOSED AND NEURO
DEVELOPMENTAL DELAY AND THE
BOTTOM TWO ARE ALCOHOL EXPOSED
YOU CAN SEE IN THE HEAT MAP HERE
IN THE SECOND AND THIRD
TRIMESTER AND CYTOKINES AND
CHEMOKINES SO Dr. BODNAR TOOK
THE DATA AND DID A CONSTRAINED
PRINCIPLE COMPONENT ANALYSIS TO
IDENTIFY NETWORKS AS IT'S
CLEARLY NOT A SINGLE CYTOKINE
WITH OUTCOMES WE'RE LOOKING AT
BUT RATHER NETWORKS SO SHE WAS
ABLE TO USING THIS APPROACH AND
PATTERNS OF EXPRESS AND
CYTOKINES ASSOCIATED WITH AND
EXPOSURE NEURO AND PATTERNS WITH
EXPOSURE AND NEURO DEVELOPMENTAL
DELAY AND THE SECOND TRIMESTER
AND A VULNERABILITY NETWORK SO
SHE'S AND SHE'S ALSO DONE A
SIMILAR ANALYSIS IN 59 CHILDREN
IN PRESCHOOL AGE AND LOOKING FOR
A DIS REGULAR NATION FOR
DEVELOPING DELAY AND AS CAN SEE
HERE, THERE'S A ALCOHOL
INDEPENDENT NEURO DEVELOPMENT
DELAY NETWORK AND THAT SEEMS TO
BE A ASSOCIATED WITH DELAY
IRRESPECTIVE OF ALCOHOL EXPOSURE
AND AN ALCOHOL RISK RESILIENCE
NETWORK AND ALCOHOL EXPOSURE
NETWORK SO FINDINGS AGAIN LIKE
THE MICRO RNAs THAT SUGGEST
THERE MAY BE BIO MARK TEARS WILL
SKATE RISK OF DEVELOPMENT AND
DELAY IN THE PRESENCE OF ALCOHOL
AND OR NOT AND REPRESENT
INTERVENTION TARGETS AND LAST I
WANT TO TALK ABOUT EARLY SON
FORRARD CONTACT AND RESPONSE AND
THIS WAS WORK AND BY JULIE TABLE
AND A CO INVESTIGATOR ON THE
STUDY FOR A NUMBER OF YEARS AND
THE RESPONSES ARE CONSERVED
ACROSS MAMMALS AND THIS WAS AN
INTEXT LOBE FUNCTIONING AND
EVALUATING A PHYSIOLOGICAL
RESPONSE TO A NOVEL STIMULI SO
THE ONES THAT WE ARE USING IN
THIS PARADIGM IS A VISUAL AND
STIMULUS AND THE RESPONSE TO
THIS STIMULUS DIVERTS OXYGEN TO
THE BRAIN AND FOCUS ENERGY AND
ATTENTION ON THE TASK OF
INFORMATION PROCESSING AND IN
TURN THAT CAUSE WITH A
DECELERATION AND THE HEART RATE
AND YOU WOULD THINK IT'S A
OPPOSITE AND THE HEART RATE AND
SO WHAT Dr. CABLE HAS SHOWN
AND YOU CAN DIFFERENTIATE
ALCOHOL EXPOSED FROM UNEXPOSED
AND THE FIGURE ON THE RIGHT AND
WITH THE BLUE-LINE REPRESENTING
UNEXPOSED RESPONDING TO THE
STIMULUS AND A HEART
DECELERATION IN THE TROUGH AND
SIGNIFICANTLY LOWER THAN THE
HEART DECELERATION AND THE RED
LINE.
YOU CAN SEE UP AT THE TOP.
A NEUROLOGIST WHO HAS BEEN
CARRYING OUT THIS ASSESSMENT AND
INFANTS HE IS PRESENTING THE
STIMULUS TO THE CHILD SITTING IN
THE CAR SEAT WHO IS HOOKED UP
WITH A VEST WITH ELECTRODES IN
IT AND THEN CAPTURING THE HEART
RATE OF THAT CHILD OF THE COURSE
TRIALS AND THERE'S A POST HOP
ANALYSIS OF THE DATA SO WE'VE
BEEN WANTING TO DETERMINE COMING
BACK TO THE CARDIAC ORIENTED
RESPONSE BECAUSE IT'S SIMPLE AND
DOESN'T REQUIRE SPECIALIZED
TRAINING AND IT'S INEXPENSIVE
WOULD DO WOULD PERFORM AS A
STANDARD NEURO DEVELOPMENTAL
CLINICAL ASSESSMENT THAT MIGHT
BE DONE FOR A CHILD TO TERM IF
THERE WAS CONCERNS FOR
DEVELOPMENTAL DELAY WITH A PRE
DOCTOR ALLEN GUINEARING STUDENT
AND WE LOOKED AT CARDIAC
ORIENTING RESPONSE COMPARED TO
THE INHAVEN'T AND HOW WELL IT
PERFORMED IN PREDICTING
PERFORMANCE ON 12 MONTHS SO
SEVERAL MONTHS LATER, AND YOU
CAN SEE IN THE FIGURE HERE AND
THE TABLE AND THAT NEGATIVE
VALUE AT SIX MONTHS FOR
PERFORMANCE ON THE BAILEY AT 12
MONTHS AND 84% AND 66% AND THE
BOTTOM OF THE TABLE YOU CAN SEE
THAT THE SIX MONTH BAILEY THE
NEGATIVE AND THE BAILEY AT 12
MONTHS WAS AND THE POSITIVE
PREDICTED VALUES 77% AND SO WE
CONCLUDED THAT THE RESPONSE WAS
SUPERIOR ON THE NEGATIVE
PREDICTED VALUE SIDE AND
COMPARABLE SO MAY HAVE AND LOWRY
IS ON THE Dr. CABLE JUST
PUBLISHED LAST MONTH ON THE
CARDIAC ORIENTING RESPONSE AND
PREDICTING FASD AT THE END OF
THE PRESCHOOL SO WHEN A CHILD
HAS CHILDREN IN THIS COHORT HAVE
HAD THE ABILITY TO PRESCHOOL
TESTING BATTERY THAT IS MORE
COMPREHENSIVE AND THAT PICK UP
FINDINGS THAT ARE FETAL CELL
SPECTRUM DISORDERS SO WHAT Dr.
CABLE DID WAS TAKE 120 CHILDREN
AND AND THE MEAN RESPONSE AT
EACH SECOND AND SHE CLASSIFIED
GREATER THAN ONE AND COUNTED AND
DEVIATION FROM THE MEAN OF THE
SAMPLE AND USE THAT TOTAL
DEVIATION SCORE AS A RISK SCORE
SO LOOKING AT THE TOTAL DEAF
DEVIATION SCORE OR RISK INDEX ON
THE CARDIAC RESPONSE IN INFANCY
SHE FOUND IT WAS HIGHER AMONG
THOSE WHO WERE ULTIMATELY
CLASSIFIED AS PARTIAL FAA OR FAS
ON THE VISUAL RESPONSE AND THOSE
WITH A ALCOHOL RELATED NEURO
DEVELOPMENTAL DISORDER DYING
KNOW SIS BUT NO PHYSICAL
FEATURES OR GROWTH DEFICIENCY OR
THOSE WITH HISTORY OF PRE-NATAL
ALCOHOL OR DIAGNOSIS AT ALL.
AND FAS STATUS SO SUGGESTING
THAT THIS CAN BE A USEFUL TOOL,
EVEN IN INFANCY FOR PREDICTING
HOW CHILDREN WERE PERFORM AND
WHAT THEIR DIAGNOSTIC
CLASSIFICATION MIGHT BE MANY
YEARS LATER.
SO WE'RE IN THE PROCESS NOW OF
ADAPTING THE CARDIAC ORIENTED
RESPONSE TO MAKE IT MORE USER
CLINIC FRIENDLY AND PARTICIPATE
FRIENDLY, PATIENT FRIENDLY SO
THEY'RE ABLE TO BE DONE
WIRELESSLY.
YOU DON'T HAVE TO PUT ON THE
VEST WITH THE ELECTRODES AND YOU
CAN DO IT WITH AN iPAD THAT
NOT ONLY PRESENTS THE STIMULUS
BUT CAPTURES THE DATA AND A
SMALL BUTTERFLY SENSOR AND USING
A STANDARD CAR SEAT FOR
POSITIONING AND THEN ALSO
BUILDING INTO THE SYSTEM
IMMEDIATE FEEDBACK SO INSTEAD OF
WAITING FOR SOMEONE TO SCORE
THIS WHOLE THING, YOU KNOW, A
MONTH LATER, THAT THE CARDIAC
ORIENTING RESPONSE FINDING
APPEAR ON THE iPAD AND IF THE
PRESENT TIME WE'RE DEVELOPING
THE BEST ALGORITHM FOR POSITIVE
VERSUS THE NEGATIVE SCREEN USING
MACHINE LEARNING TECHNIQUES SO
THE CLINICIAN WOULD KNOW THIS
CHILD NEEDS A FURTHER EVALUATION
OR THIS CHILD SHOULD BE MORE
CAREFULLY FOLLOWED.
LAST, AMONG THE TOOLS THAT I'VE
MENTIONED, WE WOULD LIKE TO
DEVELOP A SET OF TOOLS, PROBABLY
NOT ONE, THAT IDENTIFIES AT RISK
CHILDREN AS EARLY AS POSSIBLE
AND LEADS TO RECOMMENDED
INTERVENTIONS AND SUBSEQUENT
TARGETED ASSESSMENTS TO
UNDERSTAND HOW BIOMARKERS FOR
FASD VARY OR DIFFER AS CHILDREN
DEVELOP AND SEX DIFFERENCES AS
MENTIONED EARLIER AND VALIDATE
BIOMARKERS AND A CROSS CULTURAL
DIVERSE POPULATION SETTINGS SO
WE'VE DONE THIS IN ONE SETTING
IN UKRAINE UP PRIMARILY AND THEN
TO IDENTIFY BIOLOGICAL FUNCTIONS
OF BIOMARKERS SO THEY'RE .
MARKER BUT WHAT ARE THEY DOING
THAT MAY BE AMENABLE TO
INTERVENTION.
I WANT TO THANK THOSE WHO
PARTICIPATE IN IN AND NIAAA FOR
FUNDING THIS STUDY AND THE
CONSORTIUM AND MOST OF ALL I
WOULD LIKE TO THANK THE MANY
WONDERFUL PEOPLE WHO HAVE
COLLABORATED WITH US ACROSS
UKRAINE AND THE FAMILIES WHO
PARTICIPATED WILLINGLY OVER THE
LAST 15 YEARS.
THANK YOU SO MUCH.
>> THANK YOU, CHRISTINA, FOR
REALLY OUTSTANDING TALK AND
REALLY FASCINATING TO ME.
PARTICULARLY, I KNEW ABOUT THE
MRNA BECAUSE I THINK I
HIGHLIGHTED SOME OF THESE
FINDINGS IN COUNCIL BUT I DIDN'T
KNOW MUCH ABOUT THE CARDIAC
ORIENTING RESPONSE AND THE FACT
THAT IT LINKS TO THE FRONTAL
CORTEX FUNCTION AND IT MEANS
THAT EARLY ON THERE'S A FRONTAL
CORTEX FUNCTIONING, RIGHT?
>> YES.
ABOUT WHAT Dr. CABLE HAS SHOWN
IS THAT IT'S THE VISUAL RESPONSE
THAT IS AFFECTED BY ALCOHOL AND
THE AUDITORY STIMULUS RESPONSE
IS EFFECTED BY TOBACCO SO
THERE'S DIFFERENTIAL FINDINGS
WITH RESPECT TO THE PARTICULAR
SUBSTANCE AND SO IT DOES SEEM
PROGRAM ISING INPROMISING IN A O
IDENTIFY CHILDREN MOST AT RISK.
>> THAT SET UP OUR NEXT SPEAKER
I WONDER IF A SMELL RESPONSE
WOULD HAVE AN AFFECT.
WE'LL LET PAULE ANSWER THAT
LATER.
I DO HAVE A QUESTION AND I DON'T
MEAN IT COULD BE A SNARKY ONE
BUT CAN YOU MAYBE SAY WHY YOU
CHOSE THE UKRAINIAN SITE FOR THE
FIRST SITE?
>> WITH T WELL, I'M ASKED THAT N
A LOT.
ONE OF THE REASONS AND THIS IS
NOT TO BE DI DISINGENUOUS, AS I
SHOWED IN THE FIRST 12,000
PEOPLE WHO ARE RECRUITED, THE
LEVEL AND CONSISTENCY OF ALCOHOL
EXPOSURE IN THE POPULATION IS
QUITE HIGH.
AND QUITE HIGH IN PREGNANCY.
SO WE WOULD NOT SEE IN THE U.S.
PEOPLE CONTINUING TO DRINK AT
THOSE LEVELS IN PREGNANCY.
SO, A CONCENTRATED POPULATION IS
CERTAINLY AN ADVANTAGE IN TERMS
OF THE PRACTICALITY OF
CONDUCTING THIS STUDY AND THERE
ARE OTHER REASONS.
IN THE SETTINGS THAT WE'VE BEEN
WORK IT'S VERY DIFFERENT THAN IN
THE U.S. WHERE YOU HAVE TO
CO-MORBIDITY, THAT INVOLVE OTHER
TREATMENTS SO IT'S USUALLY OFTEN
TIMES POLICY SUBSTANCE USE,
OFTEN TIMES COMPLICATED BY
MATERNAL TREATMENT WITH
ANTIDEPRESSANTS AND OTHER
MEDICATIONS AND SO ON WHEREAS IN
UKRAINE, AT LEAST IN THE
POPULATIONS THAT WE'VE BEEN
WORKING IN, IT'S ALCOHOL ALONE
AND NOT COMPLICATED BY OTHER
SUBSTANCE USE TYPICALLY AND VERY
LITTLE USE OF ADDITIONAL
MEDICATIONS AND
>> INTERESTING.
REALLY INTERESTING.
SO QUESTIONS FROM ANYONE ELSE?
ARE THERE ANY COMMENTS IN THE
CHAT THAT I HAVEN'T LOOKED AT?
ANY QUESTIONS FROM ANYONE OUT
THERE?
SCOTT, DO YOU HAVE A QUESTION?
>> YEAH, I HAVE A QUICK
QUESTION.
THAT WAS A GREAT TALK AND I
REALLY ENJOYED IT.
I KNOW YOU MENTIONED THIS AT THE
END, THAT YOU HAVE PLANS TO LOOK
AT BIOLOGICAL FUNCTIONS TO SEE
WHETHER THERE'S ANY THING YOU
CAN GARNER IN TERMS OF
TREATMENT.
HAVE YOU DONE ANY PRELIMINARY
ANALYSIS OF SAY MICRO RNA
TARGETS OR OTHER THINGS THAT
GIVE YOU ANY HINTS AS TO WHAT
THESE PATHWAYS ARE POTENTIALLY
AND WHETHER THEY'RE RELATED TO
THE IMMUNE SYSTEM OR COMING FROE
THEY IMPACTING THE FETUS IN
THOSE WAYS?
>>
>> Commissioner Clements: I
THINK THAT'S WORK THAT WE ARE
CONTINUING TO DO AND HAS ANIMAL
WORK UNDERWAY TO TRY TO
DETERMINE WHAT THOSE TARGETS AND
THE ONE THAT IS KIND OF RISEN TO
THE TOP IS THIS IDEA THAT
PLACENTAL FUNCTION MAY BE
INVOLVED AND THAT THOSE MIGHT BE
REPRESENTING AN AT ANY TIME TIR
INTERVENTION.
ARE THESE MICRO RNAs INVOLVED
IN FEETAL GROWTH IRRESPECTIVE OF
ALCOHOL EXPOSURE?
IT'S JUST THIS HAPPENS TO BE ONE
PATHWAY THAT LEADS TO THAT OVER
EXPRESSION OF THESE COLLECTIVE
MICRO RNAs SO TRYING TO
DETERMINE THAT AND SIMILAR TO
WHAT Dr. BODNAR HAS BEEN
LOOKING AT.
IS IMMUNE DISREGULATION WITH
NEURO DEVELOPMENTAL DELAY IN
GENERAL AND HOW DO YOU
DIFFERENTIATE PARTICULAR TYPES
OF DELAY THAT IS ASSOCIATED WITH
ALCOHOL.
SO MORE WORK TO BE DONE AND
HOPEFULLY WE'LL BE ABLE TO DO
THAT IN A SAN DIEGO COHORT IN
THE NEAR FUTURE.
>> SO JUST, THAT'S COOL, IS THE
THOUGHT THAT THE CELLS WITHIN
THE PLACENTA ARE BEING RELEASED
AND IMPACTING THE FETUS?
IS THE SKY THE LIMIT AT THIS
POINT?
>> THE SKY IS THE LIMIT.
THE WHOLE ISSUE OF SEX
DIFFERENCES IN TERMS OF
STIMULATING OR MATERNAL
ADAPTATION TO MICRO RNA
SECRETIONS, IN TERMS OF WHICH
ONES ARE EXPRESSED, IF YOU ARE
CARRYING A FEMALE FETUS VERSUS A
MALE AND HOW THE MOTHER ADAPTS
TO THOSE AS SHE PROGRESSES
THROUGH PREGNANCY SO A
HYPOTHESIS WAS RAISED THAT YOU
ARE SEEING A SORT OF DAMPENING
OF THIS ASSOCIATION IN THE THIRD
TRIMESTER SO MAYBE THE MOTHER
RESPONDS TO THESE AND MODULATE
SO MUCH MORE TO BE DONE.
>> I'LL FOLLOW YOU.
THANK YOU, CHRISTINA, THAT WAS
GREAT.
>> THAT WAS WONDERFUL.
THE MEASURES YOU TOOK IN THEEL
TRA SOUND DIDN'T REVEAL A
PREDICTIVE INDEX.
THERE ARE SEX DIFFERENCES IN THE
RATE OF FETAL GROWTH AND THANK
YOU LOCK AT STRAT TY STRATIFYINR
RESULTS BY SEX TO SEE IF YOU CAN
POST SOMETHING OUT.
>> IT'S A GREAT SUGGESTION.
I DON'T THINK THAT ANALYSIS HAS
BEEN STRATIFIED BY SEX.
AND I DON'T MEAN TO DOWNPLAY THE
FINDINGS ON ULTRASOUNDS, THERE
WAS AN INITIAL STUDY DONE, I
DON'T KNOW, 20 YEARS AGO, THAT
FOUND DIFFERENCES ON THE
DISTANCE AND THE MEASUREMENTS WE
DID OF ORBITAL DISTANCE AND SO
ON SO THOSE ARE RELEVANT OF WHAT
IS HAPPENING AND IN DEVELOPMENT
OF THE EYE ORBIT AND HOW DOES IT
RELATE TO FISHERS IN THE CHILD
WHEN THE CHILD IS BORN SO IT'S
INTERESTING AND IMPORTANT FROM
THE STANDPOINT OF UNDERSTANDING
FETAL DEVELOPMENT BUT IN TERMS
OF BEING A BLOCK BUSTER, AS FAR
AS IDENTIFYING AN O O AFFECTED D
IT DIDN'T SEEM TO BE THERE AND
THERE IS WORK BEING DONE AT
OXFORD AND WE'VE SENT HER THE
ULTRASOUND IMAGES AND SHE'S LOOK
AT MACHINE LEARNING APPROACH TO
THIS TO SEE IF THERE ARE A FETAL
PROFILE AND OR OTHER THINGS THAT
WE AREN'T EVEN THINKING OF THAT
MIGHT BETTER DIFFERENTIATE THE
CHILD WHO IS GOING TO GO ON TO
BE EFFECTED AND INSTEAD OF THE
KIND OF CRUDE MEASURES THAT
WE'RE USING TO SEE WHAT IS IT
THAT THE ULTRA-STEN OR RA FER
CAN DO WHEN HE OR SHE IS DOING
ROUTINE SCANS BUT WE CAN LOOK AT
STRATIFICATION AND IT MAKES
SENSE AND WE'LL LET YOU KNOW HOW
IT COMES OUT.
>> THANK YOU SO MUCH.
>> MY LAST QUESTION SAY
COMMENT/QUESTION.
SINCE YOU ARE DEFINITELY PART OF
THAT HEALTHY BRAINCHILD
DEVELOPMENT, IT WOULD BE
INTERESTING TO KNOW THE
INTERACTION WITH OPIOIDS AND
ALCOHOL AND NICOTINE AND ALCOHOL
IN THESE TRAJECTORIES.
IN THE EARLY STUDIES WE WOULD
LOOK FOR THE PURE ALCOHOL
EFFECTS BUZZ I WONDER IF YOU
HAVE A COMMENT ABOUT THAT?
>>
>> IT WILL BE A UNIQUE
OPPORTUNITY TO LOOK AT 7,500
MILD CHILD PAIRS A CROSS THE
U.S. OVER SAMPLED AND FOR
SUBSTANCE USE AND SO WE'LL
REPRESENT THE EXPOSURE AND TO
OPIOID TO MARIJUANA AND TO
TOBACCO AND SO BEING ABLE TO
LOOK AT WHAT IS THE NORM IN THE
U.S. WHICH IS CO EXPOSURE TO
SUBSTANCE AND HOW THOSE INTERACT
WITH EACH OTHER AND IF THEY DO
IN TERMS OF NEURO DEVELOPMENT,
NEUROIMAGING, PERFORMANCE AND SO
ON THROUGH THE FIRST 10 YEARS OF
LIFE SO I THINK THERE'S
DEFINITELY ANIMAL EVIDENCE AND
SOME HUMAN EVIDENCE SUGGESTING
AN ALCOHOL BIBS INTERACTION AND
CERTAINLY OTHERS HAVE SUGGESTED
THAT MAYBE OPIOIDS AS WELL.
>> THANK YOU AGAIN FOR REALLY --
I GROW WITH THOSE ARE QUESTIONS
AND COMMENTS AND OUTSTANDING
PRESENTATION, CHRISTINA AND WE
LOOK FORWARD TO THE FUTURE
DEVELOPMENTS OF COURSE.
>> THANK YOU SO MUCH.
>> SO WE'RE GOING TO MOVE ON NOW
TO Dr. PAULE JOSEPH.
ARE YOU READY?
>> I AM.
>> YOU ARE.
OK, SO, GIVE ME A MINUTE TO
INTRODUCE YOU.
PAULE WILL TALK ABOUT
CHEMOSENSORY AND Dr. JOSEPH A
CLINICAL RESEARCH SCHOLAR TENURE
TRACK CLINICAL INVESTIGATOR AND
WE'RE NOT EVEN GOING TO MICK A
ACRONYM OF THAT AND CHIEF OF THE
SECTION OF METABOLISM IN THE
DIVISION OF INTRAMURAL CLINICAL
AND BIOLOGICAL RESEARCH AT THE
NATIONAL INSTITUTE OF ALCOHOL
ABUSE AND ALCOHOLISM AND AN
ASSISTANT CLINICAL INVESTIGATOR
IN THE NATIONAL INSTITUTE ON
INTRAMURAL RESEARCH AND SHE'S
ALSO A CERTIFIED NURSE
PRACTITIONER WITH CLINICAL
PRIVILEGES AT THE CLINICAL
CENTER AND WE WERE VERY MAPPY TO
HAVE HER JOIN US IN THE ALCOHOL
INTERMURAL PROGRAM FOR SOME OF
THE REASONS YOU WILL SEE WHEN
SHE GIVES A TALK BUT SHE'S
BECOME ONE OF THE WORDS EXPERTS
ON HO TASTE AND SMELL ARE
ENCODED IN THE BRAIN AND ALL THE
RAMIFICATIONS THAT HAVE SO SHE'S
BEEN REALLY HELPFUL TO ME WITH
TAKING CARE OF PRESS WHEN IT
COMES TO ALL THE THINGS
ASSOCIATED WITH COVID-19.
SHE PROBABLY IS NOT HAPPY ABOUT
IT BUT I'M HAPPY ABOUT IT.
SHE RECEIVED A MASTERS OF
SCIENCE DEGREE AS A FAMILY NURSE
PRACTITIONER FROM PACE
UNIVERSITY AND A PH.D IN NURSE
WHAT IS GENETINURSING.
SHE CONDUCTED RESEARCH AT THE
CHEMICAL SCIENCES CENTER AND
COMPLETE AID WORKFORCE DIVERSITY
POSTDOC TO BAL FELLOWSHIP AT THE
NATIONAL INSTITUTE ON NURSING
AND HER POSTDOC TO BAL RESEARCH
FOCUSES ON COMBINING CLINICAL
AND BASIC RESEARCH IN A SINGLE
RESEARCH PROGRAM BY EXAMINING
THE BRAIN-GUT INCOMPETENTER INTD
SHE CONDUCTS PRE CLINICAL,
CLINICAL AND TRANSLATION STUDIES
TO IMPROVE THE DIAGNOSIS
PREVENTION AND MANAGEMENT OF
CHEMOSENSORY DISORDERS.
SO, IT'S ALL YOURS AND CAN YOU
SEE MY SLIDES.
>> THANK YOU FOR THE INVITATION
TO SPEAK TODAY AND THANK YOU FOR
THE INTRODUCTION Dr. KOOB IT'S
FINE INFORM DURING THE PRESS
DURING COVID.
I'M TALK TO YOU ABOUT
CHEMOSENSORY WHICH IS TASTE AND
SMELL IN DISEASE AND LET'S SEE
IF THIS IS MOVING.
I HAVE NO CONFLICTS OF INTEREST
TO DISCLOSE.
SO WHY IS IT'S A NECESSARY TOO
BITTER FOR OTHERS AND WHAT MAKES
SMELL LOVELY TO SOME WHILE
OTHERS CAN SMELL NOTHING AT ALL.
AS HUMANS, WE ALL LIVE IN
DIFFERENT SENSORY WORLD'S.
AND DESPITE THESE DIFFERENCES
THERE ARE DISEASES THAT IMPACT
THE SENSORY SYSTEM LEADING TO
CHEMOSENSORY DISORDERS.
SO, TASTE AND SMELL ARE NOT
ASSESSED CLINICALLY AND PATIENTS
TEND TO REPORT THIS FUNCTION
WHEN THEY'RE PRONOUNCED EFFECTS
IN QUALITIES OF LIFE AS WE'RE
SEEING NOW IN COVID.
SO THE MISSION OF MY LAB IS TO
UNDERSTAND INDIVIDUAL VARIATIONS
IN CHEMO SENSATION AND THIS IS
IN PARTICULAR TO TASTE, SMELL
AND CHEMO THESIS SO IT'S A
SENSATION YOU GET FROM CHILLY
PEPPERS OR ALCOHOL OR PEPPERMENT
AND DOING THIS IN CLINICAL
POPULATIONS PRIMARILY AND TO
ALSO ADDRESS THE GAPS UNDERLINE
CHEMO SENSATION AND TO
UNDERSTAND HOW CHEMO SENSATION
IMPACTS PATHWAYS AND THE
MODULATE BEHAVIORS AND HOW THEY
MIGHT BE DIFFERENT IN
INDIVIDUALS WHEN OBESITY AND
ALCOHOL USE DISORDER AND BECAUSE
OF MY EXPERTISE, A POSITION ME
WELL TO REALLY RESPOND TO THE
REPORTS OF TASTE AND SMELL WHEN
COVID-19.
SO FOR THE PURPOSES OF TODAY'S
TALK, I WILL FOCUS PRIMARILY ON
COVID AND ALCOHOL USE.
SO, THIS IS AN EXAMPLE OF THE
FRAMEWORK THAT LEADS THE WORK
THAT WE'RE DOING IN OUR SECTION
WHICH IS TO STUDY HOW THE
FACTORS THAT MIGHT BE
INFLUENCING IN CHEMO SENSATION
AS YOU SEE LIFTED HERE ON THE
RIGHT OF THE SCREEN, AND ARE
EFFECTED WHEN ALCOHOL USE
DISORDERS AS WELL AS OBESITY AND
PLACES INDIVIDUALS AT RISK AND
HOW THESE IN PARTICULAR IT'S
SENSITIVE AND ONLY WE CAN CAN
SUBSTANCES AT LOW CONCENTRATION
AND WHICH WE LOOK AT SENSITIVITY
AND WE CAN ALSO MOLECULAR
COMPOUNDS THAT ARE CLOSELY
RELATED SO IN THE TIME WE HAVE
THIS AND THEY'RE ABOUT 5,000 TO
1,000 TASTE BUDS THAT IN THE
HUMAN TONGUE AND THEY'RE TOWN
ABOUT 50 TO 100 IN TASTE
RECEPTORS SO THESE HAVE TYPE ONE
CELLS AND TYPE TWO THEY WILL AND
I WON'T GO INTO THOSE DETAILS
TODAY AND ONE THING I'D LIKE TO
MOTEL IS SINCE 1962 YOU PROBABLY
HAVE BEEN SEEING A LOT OF THIS
WHICH HAS BEEN AT THIS POINT
BECAUSE WE'RE ABLE TO TAKE
SUBSTANCES THROUGH OUT THE MOUTH
HOWEVER YOU CAN STILL FIND SOME
OF THIS IN TEXTBOOKS AND SO WE
HAVE TASTES WHICH WILL BE SOUR
AND BITTER AND YOU WE HAVE THE
SWEET TASTE RECEPTORS WHICH AND
THE PARADIGM OF ONE OR TWO AND
THREE AND YOU NEED BOTH OF THEM
TO BE ABLE TO DETECH SWEET AND
THESE WILL BE SPECIFIC FOR SUGAR
AND SWEETENERS AND THEIR
ACTIVATED BY SACCHARIN AND ONE
IN PARTICULAR THAT WE'RE REALLY
INTERESTED IN THE LAB IS HAVING
FAT AS A MODALITY SO THIS IS
WORK ON ONE OF THE MOST DOCK HAS
BEEN DOING AND WE HAVE WE HAVE
IT AND REMARKLY COMPLEX AND
RECEPTORS THAT ARE ACTIVATED AND
TO DETECT AN ORDER AND SO YOU
CAN THINK OF HAVING IT IN FRONT
OF YOUR MOUTH AND THE SMELL IN
IT AND IT CURSE IN THE BACK OF
THE MOUSE SO IF YOU HAVE DONE
ONE OF THOSE EXPERIMENTS WHERE
YOU YOU "THE CLOSE" YOUR NOSE
AND YOU ARE ABLE TO PERCEIVE
THOSE FLAVORS IT'S MOST LIKELY
BECAUSE IT HAS TO BE ACTIVATED.
CONTRIBUTE OF TASTE AND SMELL
AND THERE'S A LONG LIST OF
DISORDERS THAT ACTUALLY HAVE
COST FROM INFECTION AND VIRUS WE
SEE WELL IN COVID AND DIFFERENT
DISEASES OF THE NERVOUS SYSTEM
AND DRUGS, AND THIS IS A
RELATIVE LIST HOW THERE ARE
OTHERS AND SO I'D LIKE TO PUT
THIS UP FRONT JUST BECAUSE YOU
ARE HEAR ME USE A FEW TERMS LIKE
OR HAVING A DISTORT APPROXIMATED
SENSE OF SMELL IN STOCK WHEN IT
COMES TO SMELL, TASTE AND HEALTH
WE'VE NEVER BEEN CLOSE BEFORE
AND I MENTIONED WE STARTED
WORKING WITH COVID SINCE MARCH
OF 20 AND TO DO THIS WHEN ENGAGE
IN A WORLDWIDE COLLABORATION
WHEN THE GLOBAL CONSORTIUM
CHEMOSENSORY RESOURCE AND THAT
THEY FOUNDED ALONG WITH OTHER
COLLEAGUES IN MARCH OF 2020 AND
THEY HAD 700 MEMBERS IN 66
COUNTRIES ACROSS SIX CONTINENTS.
I DESCRIBED C.E.O. CORONAVIRUS O
ACCOUNT FOR 10% TO 15% OF CASE
AND IT DOUBLED WITH THE COVID-19
AND IN SOME REPORT IT SPEAKS
ABOUT 85% AMONG COVID POSITIVE
PATIENTS SO THIS REALLY
INCREASES THE RATES AS A LEADING
CAUSE OF SENSE OF SMELLING
ADULTS.
SO WE EMBARKED IN REALLY
CONDUCTING A SYSTEMATIC REVIEW
OF META ANALYSIS AND REALLY
LOOKING AS TO WHETHER TASTE
REPORTS OF TASTE LOSS WERE TRUE
IN WHAT WAS BEING REPORTED.
SO WE KNOW THAT PRIOR TO COVID
TASTE LOSS WERE REALLY RARE AND
PEOPLE WHEN SMELL LOSS OFTEN
INCORRECTLY REPORT TASTE LOSS
AND HOWEVER, IN THIS WORK WE
ACTUALLY LOOKED AT STUDIES THAT
USED OBJECTIVE MEASURES AND WE
SEE THAT EITHER WHEN OBJECTIVES
OF OBJECTIVE MEASURES
INDIVIDUALS ARE REALLY REPORTING
TASTE LOSS.
WE ALSO LOOKED AT STUDIES THAT
HAVE LOOKED AT OBJECTIVES
TESTING FOR SMELL AND WE SEE
THAT WHEN WE HAVE OBJECTIVE
SENSORY TESTING, THERE'S A
HIGHWAY PREVALENCE FOR FACTORY
LOSS AND WE'VE SEEN IT SO THIS
IS PECULIAR WITH COVID.
THIS IS REPORTS THAT HIGHLIGHT
THE IMPACT OF COVID ON TASTE AND
SMELL AND THE DEBILITATING
EFFECTS OF DISEASE ON HEALTH
OUTCOMES AND INDIVIDUALS SAFETY
AND YOU CAN HE SEE HERE THIS
PARTICULAR ONE, FROM ONE
INDIVIDUAL THAT I CANNOT SMELL
AND TASTE WHEN THE POPCORN IS
BURNING IN THE MICROWAVE AND I
CAN TAS TASTE IT.
YOU CAN THINK THE HEALTH EFFECTS
THIS COULD HAVE SO WHEN IT COMES
TO BOYOLOGY, WE HAVE MADE
SIGNIFICANT PROGRESS IN I WILL
LOOSE DATING THE CELLULAR AND
MOLECULAR MECHANISMS ON COVID IS
HAPPENING AND SO, WE HAVE MADE
LESS PROGRESS WITH TASTE.
SO, WE KNOW THAT COVID AFFECTS
ALL THREE MODALITY, TASTE, SMELL
AND CHEMO THESIS IN A PAPER WE
REVIEWED THE EVIDENCE THAT
HIGHLIGHTS WHICH PARTS OF THE
CHEMOSENSORY SYSTEM IS SUBJECT
TO THEIR SARS-CoV-2 SO IF YOU
CAN IMAGINE, THE VIRUS ENTERING
THE RESPIRATORY SYSTEM, AND
WE'LL GO TO RESPIRATORY AND THEY
WILL FACTORY AND THEY'LL FACTORY
BOLD AND ALONG THIS PATH, MANY
ARE THE VULNERABLE TO
SARS-CoV-2 AS YOU SEE
REPRESENTED HERE IN GRAY,
BECAUSE THEY EXPRESS A SS2 SO
SEVERAL REPORTS CONCLUDED THAT
ACE 2 IS NOT EXPRESSED IN THE
FACTORY SENSORY NEURONS YET THIS
SUBPOENA OR THING CELLS ARE
EFFECTED AND IMPAIRED THE
FUNCTIONING OF THESE FACTORY
NEURONS CAUSING THE DYSFUNCTION.
THERE'S A PAPER EXAMINING
POSTMORTEM SAMPLES OF PATIENTS
WHO DEVELOPED COVID-19 COMPARED
TO CONTROL PATIENTS AND THEY
WERE ABLE TO CONFIRM THAT THE
CELLS ARE THE MAIN CELL TYPES
THAT ARE AFFECTED BY THE
SARS-CoV-2 AND THAT SUBSTANCE
CELLS WOULD SUPPORTING CELLS ARE
THE MAIN TARGETS CELL TYPES IN
THE FACTORY BUZZ THERE'S NO
EVIDENCE OF INFECTION IN THOSE
FACTORY SENSORY NEURONS.
SO AS I SAID, THERE'S MUCH LESS
THAT IS NOT ABOUT TASTE AND AS
WE KNOW SARS-CoV-2 BINDS TO
THE RECEPTOR AND IT WAS KNOWN
WHETHER ACE 2 IS EXPRESSED ON
THE TASTE RECEPTORS CELLS
HOWEVER, WORK BY Dr. JOSEPH
EGIN FROM NIH SHOWN THAT ACE 2
IS IN TYPE 2 CELLS IN THE TASTE
BUDS AND THIS PRESENCE CAN MOST
LIKELY BE A MODE OF ENTRY OF THE
VIRUS INTO THE ORAL CAVITY
HOWEVER THERE'S NOT MUCH WORK
DONE IN TERMS OF THE TASTE
SYSTEM.
SO, WE DIDN'T WANT TO REALLY
VALIDATE SOME OF THESE PATIENT
REPORTS THAT I SHOWED YOU THAT
WERE COMING UP SO WE THEN WANTED
TO UNDERSTAND WHAT ARE THE
PROFILES OF THIS COVID-19
INDIVIDUALS.
AND IN PARTICULAR JUST REALLY
UNDERSTANDING THE MODALITY WHERE
THE QUALITATIVE VERSUS
QUANTITIVE CHANGES AND SOME OF
THE SIMILARITY AND DIFFERENCES
BASED ON OTHER RESPIRATORY
ILLNESSES SO NORMALLY WE WOULD
DO OBJECTIVE MEASURES BUT THIS
WAS NOT POSSIBLE AT THE
BEGINNING OF COVID DUE TO THE
INCREASE EXPOSURE TO THE VIRUS
WAS MAKES US THINK OUTSIDE THE
BOX AND SO AS I SAID MYSELF AND
OTHERS DEVELOPED A NUMBER OF
TOOLS, ONE WHICH IS THIS THE
SURVEY WHICH WAS DEPLOYED IN
APRIL OF 2020 AND IT WAS
TRANSLATING TO 36 DIFFERENT
LANGUAGES AND AT THE SAME TIME,
WE AND OTHERS ALSO LOOKED AT THE
ACCURACY OF THIS SUBJECTIVE
MEASURES IN THIS CONTEXT AND WE
ASKED BEFORE AND MEASURES OF
TASTE AND SMELL, AS WELL AS
NASAL BLOCKAGE AND A NUMBER OF
OTHER SYMPTOMS BEFORE DOING AND
AFTER THE DISEASE AND THIS WAS
DONE IN 100 POINT VISUAL
ANALOGUE SCALE AND IN OUR FIRST
PAPER, BASED SON ABOUT 4,000
RESPONDENTS SO THIS WAS
PUBLISHED PRETTY QUICKLY FROM
THE POINT THAT WE LAUNCHED THE
SURVEY, WE IDENTIFIED THAT
COVID-19 WAS ASSOCIATED WITH
SMELL, TASTE AND CHEMO THESIS
BUT I WANT TO TALK ABOUT THE
PAPER WHERE WE SET OUT TO
UNDERSTAND WHETHER AND HOW
CHEMOSENSORY SYMPTOMS WERE
REPORT AND COVID-19 POSITIVE
COMPARED TO THOSE WHO HAD OTHER
RESPIRATORY ILLNESSES SO WHEN
DATA ON ABOUT 16,000
PARTICIPANTS WE AIMED AT
ANSWERING THREE QUESTIONS AND
ONE CAN WE VALIDATE THE REGIONAL
OBSERVATION THIS IS A NEW SAMPLE
AND CAN WE USE THE DIFFERENCE IN
SELF-REPORT FROM PARTICIPANTS
THAT RECEIVED A POSITIVE OR
NEGATIVE RESULT OF COVID WHEN A
PCR TEST AND USED THEM TO
PREDICT AN INDIVIDUAL COVID-19
STATUS AND THIRDLY, HOW DO
PARTICIPANTS RECOVER FROM SMELL
LOSS AND IT'S DIFFERENT FROM
OTHER RESPIRATORY ILLNESSES SO
IN DEED WE WERE ABLE TO VALIDATE
OUR FIRST FINDINGS WHERE WE
STILL SAW THERE WAS THIS
SIGNIFICANT SMELL LOSS WHEN WE
COMPARED INDIVIDUALS BEFORE AND
DURING THE DISEASE, AND THEY HAD
COVID AND DIDN'T HAVE COVID AND
FOR SMELL THIS WAS ABOUT EIGHT
POINT DECLINE AND SIGNIFICANT
TASTE LOSS ABOUT SIX POINTS
DECLINED AND AGAIN BEFORE AND
FROM BEFORE AND DURING THE
DISEASE, AND WE STILL SAW A
SIGNIFICANT REDUCTION IN CHEMO
THESIS ALTHOUGH LESS PRONOUNCED
ABOUT A 40 POINTS REDUCTION SO
WHEN WE DESIGNED THE SURVEY,
THEY WERE BINARY QUESTIONS AND
HOWEVER, ALTHOUGH A BINARY
QUESTION WORKS AND IT'S OK BUT A
QUANTITIVE QUESTION LIKE SMELL
DURING ILLNESS AND GOING FROM 0
TO 100 WORKS 10% BETTER AS YOU
CAN SEE.
WHEN YOU CONSIDER THE OVER ALL
BEST MODEL AND I THINK COVID
POSITIVE AND COVID NEGATIVE AND
THE SYMPTOMS AND FEVER AND COUGH
AND THEY DID NOT DO BETTER THAN
CHANCE WITH THE AREA .54 AND
HOWEVER WHEN WE HAVE QUESTIONS
AND SMELL DURING THE DISEASE
THESE OUT PERFORMED THE TROY FOR
15% AND AND THE BEST MODEL IN
OUR HANDS WAS SMELL DURING
ILLNESS AND THE CRITICAL POINTS
72 AND THIS WAS REALLY IMPORTANT
IN THE SENSE INFORMED, YOU KNOW,
THE PUBLIC TO REALLY START
MONITORING THEIR SMELL AND AND
AS YOU PROBABLY CAN REMEMBER,
IT'S ONE OF THE QUESTIONS ADDED
IN THE SCREENERS FOR DURING
COVID.
SO WE SET OUT TO INVESTIGATE HOW
RECOVER RE FROM SMELL OUTLOOKS
IN PARTICIPANTS WITH COVID AND
OTHER RESPIRATORY ILLNESSES AND
WE IDENTIFIED THREE MAIN
CLUSTERS AND THOSE ARE RECOVERED
FROM SMELL AND THEY HAVE
PERSISTENT SMELL LOSS AND INDEX
SMELL AND WHEN COVID AS I SAID
TEND TO LOSE THEIR SMELL MORE
OFTEN AND 40% EVER THEM IS SENSE
OF SMELL WITHIN 40 DAYS.
SO THIS DATA WENT BOTH OBJECTIVE
AND SUBJECTIVE REPORTS AND WE
ARE ALL COMING TO THE SAME
CONCLUSION THAT TAKES AN HOUR OF
THREE WEEKS AND 80% RECOVER BY
60 DAYS HOWEVER AS YOU MIGHT BE
AWARE THERE'S 15% TO 20% SHOWING
PERMIT AFTER 90 DAYS AND THESE
ARE THESE INDIVIDUALS THAT ARE
EVEN TWO YEARS OUT, SINCE THE
INITIAL REPORTS OF COVID AND THE
STATES REPORTED THAT IT SENDS TO
RECOVER FASTER THAN SMELL AND WE
STILL DID KNOW WHY SO THIS IS
RAISING CONCERNS THEY COULD BE
ABOUT 15 MILLION NEW PEOPLE WITH
THE SMELL DISORDERS AND WE DON'T
HAVE AN ESTIMATE YET IN TERMS OF
TASTE.
SO I MENTIONED I WOULD TALK
BRIEFLY AND TALK ABOUT THE
DISTORTED SMELL PERCEPTION AND
THAT INDIVIDUALS CAN HAVE AND
IT'S A HALLUCINATION AND SO WE
DID A FOLLOW-UP STUDY WHERE WE
CONTACTED PEOPLE FROM OUR STUDY
AND WE WANTED TO UNDERSTAND THE
REPORTS OF PAROSMIA AND
PHANTOSMIA.
SO, ON THIS FOLLOW-UP SURVEY,
WHAT WE DID WAS REALLY TRIED TO
FIGURE OUT HOW MUCH OF THESE
DEVELOPED AND ABOUT 63% OF THEM
WHAT WE CALL SMELL LONG HOLDERS
REPORTED IT AND 33% OF THESE
INDIVIDUALS REPORTED TO HAVE THE
A IN GENERAL, THE LOUNGE HAULERS
ARE HAVING MORE FATIGUE AND
ALLUSIONATION, HAIR LOSS, BRAIN
FOG AS WELL AS HEADACHES AND
MEMORY LOSS AND AGAIN OUR
FINDINGS ARE CONSISTENT WHEN THE
LARGE SURVEY OF PEOPLE FROM THE
OFFICE THE NATIONAL STATISTIC IN
THE UNITED INCOME KINGDOM AND
YOU MIGHT ASK ABOUT NEW
VARIANTS.
WITH OMICRON THERE WAS LESS
TASTE AND SMELL LOSS AND WHEN
THE OTHER VARIANTS WE HAVE AND I
KNOW THAT IT'S REALLY RARELY
REPORTS OF LOSS OF SMELL AND
TEST WITH FLU AND COLD SO IN THE
NEXT FEW MINUTES WE HAVE LEFT, I
WANT TO PRESENT THE RESULTS ON A
STUDY ON A COLLABORATIVE STUDY
WE'RE DOING AND DID VJ MENTIONED
AND SO THIS DATA WERE COLLECTED
DURING COVID SO WE USED THE SAME
SURVEY I SHOWED EARLIER TO
CAPTURE THE SYMPTOMS AND JUST IN
PARTICULAR, I REALLY LIKE THIS
PAPER BECAUSE IT REALLY TALKS
ABOUT THE LACK OF WORK THAT IS
DONE AROUND FACTION WHEN IT
COMES TO IN THE ALCOHOL FIELD IT
REALLY PROVIDES INSPIRATION FOR
SOME OF THE WORK WE DO IN THE
LAB.
SO WE KNOW THAT THE ALCOHOL
EXPOSURE TASTE AND SMELL
PATHWAYS AND ALCOHOL HAS STRONG
CHEMO AND THEY WILL SMELL AND
TASTE WHEN AE D AND MOST OF THE
WORK HAS BEEN DONE IN PRE
CLINICAL STUDIES AND THEY HAVE
THE ABILITY TO DISCRIMINATE
TASTE AND SMELL AND SO IN THIS
PARTICULAR ANALYSIS WE WANT TO
EXERCISE REPORTS OF CHEMO
SENSORY OF INDIVIDUAL WITH
DIFFERENT AND PAY CHANGES IN
QUALITY OF LIFE AND SPECIFICALLY
PHYSICAL AND ENVIRONMENTAL
HEALTH AND WE HAVE DIFFERENT
TASTE AND SMELL ACTSES AND
ALCOHOL AND THEY AND SHOW LOWER
TASTE AND SMELL SCORES AND THE
LOSS OF TASTE AND SMELL OF HEAVY
DRINKERS THAT WILL BE NEGATIVELY
EFFECTED WITH THE QUALITY OF
LIFE.
SO WE HAVE ABOUT 466
PARTICIPANTS AND THIS WAS DONE
DURING COVID SO SURPRISINGLY WE
ONLY HAD 17 INDIVIDUALS WITH A
COVID POSITIVE DIAGNOSIS AND WE
EXCLUDED THEM AND WE EXCLUDED
NINE OF THEM THAT WERE OLDER
THAN 70 BECAUSE WE KNOW AGE HAS
AN EFFECT ON TASTE AND SMELL SO
WE HAD ABOUT 440 PARTICIPANTS OF
THESE FROM JUNE TO SEPTEMBER OF
2021 AND IT WAS DONE THROUGH
QUESTIONNAIRES DUE TO THE NATURE
OF THE TIMING AND THIS
PARTICIPANTS COMPLETED THIS
QUESTIONNAIRE AT ENROLLMENT AND
WEEK FOUR.
EIGHT AND 12 SO WE USE A GROUP
BASED TRAJECTORY AND THE AUD
CONSUMPTION INTO HEAVY MODERATE
AND NON ALCOHOL DRINKING BEHAVE
YEARS AND AS YOU CAN SEE THE
MAJORITY OF THE PARTICIPANTS
WERE MAUD A MODERATE DRINKERS.
THERE WAS A HIGHER PERCENTAGE OF
MALES IN THE HEAVY DRINKING
GROUP.
AND WE HAD A PERCENTAGE IS
SMOKERS WAS HIGHER AMONG THE
HEAVY DRINKERS BECAUSE WE KNOW
WE HOLE IN THIS ANALYSIS.
SO, WHEN WE LOOKED AT THE SMELL
ABILITY OF HEAVY DRINKERS, AND
LOWER AND SHOWED MARGINAL
SIGNIFICANCE THAN IN THE NON
DRINKERS.
AND WHILE THIS DIFFERENCE WAS
NOT SEEN IN THE INDIVIDUALS AND
AS WE CAN SEE AND BE.
WE ALSO OBSERVED THAT LOWER
QUALITY OF LIFE SCORES AND WHILE
MODERATE DRINKERS HAS THE
PSYCHOLOGICAL DOMAIN WAS
EFFECTED.
AS WE CAN SEE IN PANEL B SO
THEN, LASTLY, ONE OF THE THINGS
THAT WE WANTED DO IS TO REALLY
SEE THE RELATIONSHIP BETWEEN THE
CHEMOSENSORY ABILITY AND QUALITY
OF LIVES DOMAINS AND WE SAW A
STRONG POSITIVE BETWEEN THE
REDUCED SMELL AND QUALITY OF
LIFE DOMAINS THAT WAS MORE A
PARENT IN THE HEAVY DRINKERS AND
INDICATING THE LOSS OF TASTE AND
SMELL NEGATIVELY IMPACTED THE
QUALITY OF LIFE AS WELL.
SO IN CONCLUSION, HEAVY DRINKERS
WERE ASSOCIATED WITH LOWER
CHEMOSENSORY ABILITIES AND THEY
HAVE REDUCED SMELL AND TASTE
FUNCTION AND IS HE WE WANT THE
ALCOHOL BEVERAGE THEY HAVE AND
THE EFFECTS AND ALSO LIKE HAVING
OBJECTIVE MEASURES WHEN THEY ARE
ABLE TO COME INTO THE NIH AND
WITH THAT I WANT TO GIVE YOU A
LITTLE BIT OF A FLAVOR OF THE
NEW PROTOCOLS WE HAVE.
IN TERMS OF COVID, WE HAVE
SEVERAL COLLABORATIONS WHERE WE
COLLECT TASTE AND SMELL AND AS
WELL AS A LONG-HAULER STUDY AND
WE ALSO HAVE A COLLABORATION
WITH A COLLEAGUE AT COLOMBIA IN
WHICH WE REALLY LOOK AT POST
MODEL SAMPLES AND WE'RE
INTERESTED IN INTERESTING MORE
AND FOR OUR OWN PRODUCTS, ONE
THAT IS SPECIFIC IN OBESITY
LOOKING AT BIOLOGICAL OF
CORRELATES AND TASTE AND
SENSITIVITY AND OUR ALCOHOL
STUDY ALSO LOOKS AT TASTE AND
SENSITIVITY IN AUB AND ONE
PARTICULAR AREA THAT WE'RE
INTERESTED IN STUDY AND HOW
INFLAMMATION AND I WAS LIKE
ARISE INTERESTING OBESITY AND
ALCOHOL PLACE A ROLLED AND IN
THIS INDIVIDUAL.
AND THE LAST THAT WE HAVE ON
GOING IS WORK THAT HAS BEEN DONE
ON THE FIELD AND IN THIS IS WORK
IN COLLABORATION WITH Dr.
DANNY REED AND GRATEFUL THAT
Dr. DAVID GOALMAN HAS JOINED
US TO PROVIDE ADVICE IN TERMS OF
ANALYSIS IN TERMS OF THE DATA AS
WELL AND I JUST WANT TO END HERE
AND JUST REALLY SHOW NA NONE OF
THIS WORK WOULD NOT HAVE BEEN
POSSIBLE WITHOUT THE
COLLABORATION AND JUST ALL OF US
UNDERSTANDING ABOUT MORE OF THE
TASTE AND SMELL DISORDERS AND I
WANT TO THANK MY LAB FOR ALL
THEIR WORK AND AS WELL AS ALL OF
THE PARTICIPATE WE HAVE ACROSS
THE GLOBE AND WITH THAT I'LL
TAKE SOME QUESTIONS.
>> THANK YOU FOR A AN EXCELLENT
TALK.
I HAVE A QUESTION THAT I
COULDN'T WAIT TO ASK YOU AND
BECAUSE I KNOW THE RAT STUDIES.
DO INDIVIDUALS WHO HAVE A LOSS
OF SMELL, IS THERE A LINK TO
EFFECTIVE DISORDERS TO NEGATIVE
EMOTIONAL STATES AND I'M
ASSUMING THERE IS BUT I WONDER
ABOUT THE LITERATURE IN HUMANS
BECAUSE IN RATS THAT USED TO
TAKE OUT THE BULB AND MAKE RATS
DEPRESSED BUT WHEN THE HUMANS
AND IS THERE A LINK AND TIE IN
WITH YOUR WORK ON ALCOHOL.
>> YES, ABSOLUTELY.
IT'S A GREAT QUESTION.
SO YES, THERE IS WORK IN TERMS
OF ROLL AND DEPRESSION AND PLACE
A ROLE AND THERE'S LITERATURE ON
THAT AND THERE'S NOT TWO BOTH IN
TERMS OF ALCOHOL AND THE
DEPRESSION AND STUD THESE HAVE
BEEN DONE IN HUMANS AND THEY'RE
VERY SMALL AND NEEDS A LITTLE
BIT OF FOLLOW-UP IN TERMS AND AT
MECHANISTICALLY WHAT IS GOING OR
NOT AND HOW, ESPECIALLY THE OLD
FACTORY SYSTEM EFFECTED IS AND
THERE'S A LITTLE BIT LESS DONE
WITH TASTE.
>> THAT'S INTERESTING.
CHRISTINA HAS A QUESTION.
>> THAT WAS A GREAT
PRESENTATION.
THIS IS PROBABLY TOO FAR IN THE
WEEDS BUT WITH CHEMICAL, WITH
ALCOHOL INDUCED OR VIRAL INDUCES
LOSS OF SMELL AND OPPOSED TO
CONGENITAL INABILITY TO SMELL IS
THERE A LINK TO INFERTILITY?
>> THAT'S A GOOD QUESTION.
I HAVEN'T REALLY TALKED MUCH
ABOUT IT AND I SAW A FACTORY
RECEPTORS IN THE SPERM AND SO WE
KNOW THAT THERE'S SEVERAL
FACTORY QUEEN'S THAT IS EFFECTED
BUT IN TERMS OF FROM AND HOW
THAT IS RELATED TO INFERTILITY
AND HAVEN'T DONE MUCH ON THAT
BUT IT'S A GREAT QUESTION.
>> ARE THERE QUESTIONS FROM
COUNCIL LESLEY CLARK?
>> YES, THAT WAS Dr. JONES,
THAT WAS A GREAT PRESENTATION
AND I KNOW ALCOHOL IS ONLY A
PART OF THE SPECTRUM OF INTEREST
AND I WAS WONDERING IF THERE'S A
DINK TUN BETWEEN HIGH ALCOHOL
AND SPIRITS AS OPPOSED TO LOWER
ALCOHOL CONTENT BEVERAGES LIKE
BEER OR WINE?
>> THAT'S A GREAT QUESTION.
SO, THAT'S WHY ONE OF THE THINGS
AND WE REALLY ARE INTERESTED IN
KNOWING IS ONE THE TYPE OF
ALCOHOL THESE INDIVIDUALS HAD
DRINKING WITH AND WHETHER
THERE'S AN EFFECT ON HOW THIS
DIFFERENT TYPES OF ALCOHOL HAS
IN THE SENSORY SYSTEM AND I
HAVEN'T SEEN ANY PARTICULAR
PAPERS THAT HAVE BEEN ABLE TO
REPORT ON THIS AND I HOPE THAT
THIS DATA THAT WE ARE GOING --
WELL, BEER GOING TO COLLECTED TO
DATA TO OUR CLINICAL PROTOCOL
THAT HOPEFULLY GETS APPROVED.
>> GREAT!
>> THANK YOU.
THANK YOU.
>> ANY OTHER QUESTION.
I'M GOING TO CHARGE YOU.
WHAT ABOUT SIX DIFFERENCES AND
ARE THERE ANY THAT CAME OUT WITH
THE COVID PANDEMIC?
>>
>> THERE ARE SEX DIFFERENCES SO
A LOT OF THE REPORTS ON
ESPECIALLY WHEN COVID WE'VE SEEN
AND FEELS AND MORE THAN MALES
AND THAT COULD BE ATTRIBUTED
PHONE NUMBER OF REASONS BUT JUST
IN GENERAL IN TERMS OF SEX
DIFFERENCES IN TASTE AND SMELL
THAT'S BEEN DOCUMENTED IN THE
LITERATURE AND OVER TIME SO THEY
ARE IN SEX DIFFERENCES.
>> CAN I JUST ADD --
>> YOU HAD SUCH A LARGE
POPULATION AND IT WAS LIKE 75%
WOMEN.
ARE YOU ABLE TO JUST LOOK AT SAY
WOMEN AGE 50 AND OLDER AS A
PROPROXY FOR POST MENOPAUSAL STS
TO SEE HOW IT'S EFFECTING THE
COVID IN PARTICULAR?
>> WE CAN.
WE HAVEN'T DONE THAT AND WE'VE
DEFINITELY CAN AND YES, WE HAVE
A VERY LARGE DATA SET SO WE CAN
DO THAT AND WE ARE ALSO
PARTICULARLY INTERESTED IN WE
LOOK AT DIFFERENT WAYS JUST
TRYING TO SEE FROM THE
DIFFERENCE THERE'S AS WELL AND
GREAT QUESTION AND THANK YOU SO
MUCH.
>> THERE'S WORK IN THE ANIMAL
LITERATURE THAT SUGGESTS THAT
ESTROGEN WILL IMPACT TASTE AND
SMELL SO, THAT WOULD BE REALLY
INTERESTING TO FIND OUT.
>> THANK YOU.
>> ANY OTHER COMMENTS OR
QUESTIONS?
>> THANK YOU, PAULE.
I LOOK FORWARD TO ALL THESE
EXCITING PROJECTS THAT YOU HAVE
UNDERWAY AND I TOTALLY AGREE
WITH YOU.
THE COLLABORATION IS ALSO IN
SOME SETS PART OF A DIVERSITY
ISSUE AND I THINK WHEN MULL ABLE
GROUPS GET TOGETHER AND MUCH
MORE RICH ENVIRONMENT FOR
THINKING UP INNOVATIVE AND OUT
OF THE BOX THINGS AND ALL OF YOU
WHO WORK ON CON HAVE SLUMS AND
CHRISTINA CHAMBERS HAS SEEN THE
SAME THING WITH THE FETAL
ALCOHOL DISORDER AND IT IT
ENHANCES OUR RESEARCH EFFORT AND
WE'LL BE TALK ABOUT NA IN THE
FUTURE.
IT'S TIME FORT BRAIN INITIATIVE
UPDATE?
>> YES, Dr. EBERWINE IS IT
ON-LINE AS WELL AS CHANGHAI CUI.
>> IT'S A PLEASURE TO SEE JIM
EBERWINE HE IS A FORMER STANDING
MEMBER OF OUR NATIONAL ADVISORY
COUNCIL ON ALCOHOL ABUSE AND
ALCOHOLISM THE HE IS PROFESSOR
OF PHARMACOLOGY AT THE
UNIVERSITY OF PENNSYLVANIA
SCHOOL OF MEDICINE AND HE MAY
NOT KNOW IT BUT I DRAFTED HIM TO
SERVE ONE MORE YEAR ON OUR
REPRESENTATIVE TO THE BRAIN
INITIATIVE SO, AND YOU KNOW,
MAYBE I SHOULDN'T SAY THIS BUT
THEY MUMBLED ABOUT IT HE HAS
BEEN ON A LONG TIME BUT HE IS SO
VALUABLE AND SO YOU ARE ON FOR
ANOTHER YEAR IF YOU WILL DO IT?
ANYWAY, HE IS THE REPRESENTATIVE
TO THE COUNCIL WORKING GROUP
WHICH PROVIDES OVERSIGHT OF THE
LONG-TERM SCIENTIFIC VISION OF
THE BRAIN INITIATIVE AND HE IS
ALSO A MEMBER OF THE ETHICS
COMMITTEE, RIGHT.
I'LL TURN IT OVER TO YOU.
BUT THANK YOU SO MUCH FOR DOING
THIS AND THANK YOU FOR DOING IT
ANOTHER YEAR AND WE'RE LOOKING
FORWARD TO UNDATE FROM YOU AND
CHANGHAI CUI AND WILE GET TO
CHANGHAI CUI LATER.
I'LL INTRODUCE CHANGHAI CUI AT
THE SAME TIME SO YOU CAN JUST GO
WITH THE FLOW FROM FROM
NEUROSCIENCE AND BEHAVIOR AND
I'VE BEEN VERY ACTIVE IN THE
BLUE PRINT AND THE BRAIN
INITIATIVE AND SHE'S ONE OF OUR
REPRESENTATIVES ON THE BRAIN
INITIATIVE.
>> CAN YOU SHARE YOUR SLIDES
NOW?
>> GREAT.
>> THANK YOU, GEORGE.
NICE TO SEE YOU, GEORGE, NICE TO
SEE YOU ABE AND OF COURSE GEORGE
I'M ALWAYS HAPPY TO DO.
IT'S DIFFERENT THAN ANYTHING
YOU'VE DID NOT DOING SO I'M
HAPPY TO DO MY PART.
FOR THE BRAIN INITIATIVE, IT HAS
BEEN A PLEASURE TO BE THE
REPRESENTATIVE OF NIAAA ON THE
BRAIN INITIATIVE SINCE IT'S
INCEPTION.
AND SO IT'S BEEN FUN TO SEE HOW
THINGS HAVE CHANGED OVER TIME T
FOR THIS PARTICULAR UPDATE, IT
WILL BE ME LEADING OFF AND THEN
Dr. KU CUI AND I WILL FINISH UP.
I WANT TO EMPHASIS THE FACT THAT
BOTH Dr. CUI AND GEORGE HAVE
BEEN VERY IMPORTANT MEMBERS OF
THE BRAIN INITIATIVE, VERY
ENGAGE AND VERY INVOLVED AND SO
IT'S GREAT THAT THE BRAIN
INITIATIVE IS BETTER BECAUSE OF
EVERYONE'S INVOLVEMENT.
DIFFERENT THEI HAVE CAN THE NEX,
CHANGHAI CUI.
>> SO WE HAVE SET ADMINISTRATIVE
STRUCTURES FOR THE BRAIN
INITIATIVE.
Dr. NAI IS THE DIRECTOR OF
BRAIN INITIATIVE AND I WAS
ACTUALLY ON THE SEARCH COMMITTEE
FOR THE DIRECTOR A COUPLE YEARS
AGO AND HE IS IN PLACE FOR ABOUT
A YEAR AND MAYBE A LITTLE OVER A
YEAR NOW AND HIS DEPUTY DIRECTOR
IS MITCH NER AND JOHN WAS A
PROFESSOR OF BERKELEY BEFORE
BECOMING DIRECTOR ARE BRAIN
INITIATIVE AND THEY'RE DESCRIBED
MOMENTARILY AND SHE'S A PROGRAM
OFFICER THERE AT THE NIH AND
BEEN INVOLVED AND INVOLVED WITH
THE BRAIN INITIATIVE FROM THE
VERY ONSET AS WELL.
AND I THINK ME MAKE A GREAT TEAM
IN MOVING THE BRAIN INITIATIVE
FORWARD AND OF COURSE THE REST
PEOPLE ARE INVOLVED IN THE
INITIATIVE.
FOR THOSE OF YOU THAT DON'T
KNOW, BRAIN STANDS FOR BRAIN
RESEARCH THROUGH ADVANCING NEURO
TECHNOLOGIES SO A LOT OF THE
BRAIN INITIATIVES IS FOCUS ON
IMPACTING HOW WE CAN ASSESS AND
ANALYZE QUANTITIVELY OBSERVE THE
BRAIN AND THE HOPE IS THAT
THERE'S INSIGHTS WOULD BE
TRANSLATED INTO THE CLINICAL I
CLINIC ATSOME POINT.
JOHN HAS RECENTLY SET UP A SITE
ON THE BRYN INITIATIVE WEBSITE
AND CALLED THE BRAIN DIRECTOR'S
CORNER AND HE PUTS UP THINGS OF
INTEREST TO THE BRAIN COMMUNITY.
WHEN I SAY THE BRAIN COMMUNITY,
I MEAN PEOPLE WHO ARE FUNDED OR
INTERESTED IN THE BRAIN
INITIATIVE FOR THE GENERAL
COMMUNITY SO ANYONE WELCOME 20
TOGO TO THE WEBSITE AND NEW
FUNDING OPPORTUNITIES ARE SHOWN
HERE AS WELL AS WELL AS OTHER
ACTIVITIES OF THE BRAIN
INITIATIVE SOME WHICH I'LL
HIGHLIGHT AS I MOVE FORWARD.
SO I ENCOURAGE ALL OF TO YOU GO
TO THE WEBSITE TO GET THE MOST
UP-TO-DATE INFORMATION.
SOP SOME OF YOU WHO HAVE BEEN ON
COUNCIL FOR A LITTLE WHILE, KNOW
THAT A COUPLE YEARS AGO, THE
DIRECTOR OF NIH ASKED FOR REVIEW
OF THE BRAIN INITIATIVE AND SORT
OF THE HALFWAY POINT AND THERE
WERE TWO INITIATIVES BEFORE.
ONE ON REVIEWING WHETHER THE
BRAIN INITIATIVE IS DONE AND
WHERE IT CAN MOVE FORWARD IN
TERMS OF SCIENTIFIC EFFORTS AND
THE OTHER WAS WITH RESPECT TO
NEURO ETHICS AND SO WITH REGARD
TO THE MOVEMENT OF SCIENCE,
THROUGH THE NEXT PHASE OF THE
BRAIN INITIATIVE, THAT COMMITTEE
THAT WORKED TO ASSESS WHERE
NEUROSCIENCE IS AND WHERE THE
BRAIN INITIATIVE IS CAME UP WITH
A REPORT AND SUGGESTED SEVERAL
TRANSFORMATIVE PRODUCTS THREE OF
WHICH ARE MOVING FORWARD NOW AND
THESE ARE HIGHLIGHTED RECENTLY
BUT SHE DISCUSSED THEM IN
DETAILS AND IT'S A CONNECTIVITY
MAP AND TOOLS FOR PRE SESSION
ACCESS TO NEURO CELL TYPES IN
SUB REGIONS OF THE BRAIN AND I
WANT TO HIGHLIGHT AS GEORGE WAS
HIGHLIGHTED, Dr. JOSEPH BEFORE
HIM, COLLABORATIVE SCIENCE AND
COLLABORATIVE EFFORTS MAKE
THINGS BETTER AND GET THINGS
DONE IN TIME A TIMELY MATTER.
THIS IS WHERE MANY DIFFERENT
INSTITUTES ARE INVOLVED AND SO
JUST HIGHLIGHTED ARE THE NIAAA
OFFICERS.
YOU CAN SEE CHANGHAI CUI IS ON
THIS AND ANTONIO IS ON THIS CALL
PERHAPS AND THE OTHERS ARE ON
THE CALL AND THEY'RE ALL
ACTIVITY INVOLVED IN DEVELOPING
RFAs AND MAKING IT A
SUCCESSFUL PROCESS BUT YOU CAN
SEE THERE'S MANY PEOPLE ACROSS
THE NIH WHO NOT ONLY DO THEIR
STANDARD DAY JOB BUT ALSO DO
THESE ADDITIONAL JOBS TO MAKE
THIS A SUCCESS.
THE WAY IN WHICH BRAIN IS
SUBDIVIDED IN TERMS OF THINKING
ABOUT THE SCIENCE MOVING IT
FORWARD AND ASSESSING WHAT'S
BEEN DONE IS THROUGH THESE
DIFFERENT TEENS.
SO, TEAM A IS BRAIN CELLS AND
CIRCUIT ANALYSIS IN SOME OF THE
TRANSFORMATIVE HAVE BEEN DONE BY
TEAM A AND TEAM N AND SO
BASICALLY EVERY GRANT THAT GOES
OUT, EVERY RFA AND GRANT THAT
COMES IN IS FUNDED IS ASSAULT
AND BASUBDIVIDEDFOR ADMINISTRATD
MOVEMENT FORWARD.
AND AGAIN THESE ARE PEOPLE FROM
VARIOUS INSTITUTES THAT ARE
INVOLVED PROGRAM OFFICERS
INVOLVED IN THE BRAIN INITIATIVE
AS WELL.
FUNDING FOR THE BRAIN INITIATIVE
HAS ACTUALLY BEEN QUITE GOOD.
THERE'S INITIAL FUNDING WAY BACK
IN 2014 AND 2015 WHEN IT WAS
INITIATED WITH A GOAL OF HAVING
OVER $5 BILLION SPENT ON BRAIN
FUNDED PROJECTS AND THROUGH
2025-2026.
AND SO, SOME OF THIS IS THROUGH
BASE NIH CONGRESSIONAL FUNDING
AND IN RED AND THE RED BARS AND
THEN 21st CENTURY CURES
FUNDING IS REPRESENTED BY THE
YELLOW BARS.
THIS IS YEAR BY YEAR FUNDING.
WHERE THESE ARE ADDED ON TOP OF
THE CONGRESSIONAL FUNDING AND
YOU CAN SEE IN YEAR 2022 WE'RE
AT THE FUNDING GOAL FOR WHAT WE
EXPECT TO SPEND THIS YEAR AND
THE HOPE IS THAT THERE WILL BE
MORE THAN THAT FROM THE CURERS
FUNDING AND IN PARTICULAR NEXT
YEAR THERE'S MONEY COMING IN FOR
THE CURES INITIATIVE AND THAT IS
ONE OF THE REASONS THE
TRANSFORMATIVE PRODUCTS HAVE
GOTTEN OVER THE GROUND AND
THEY'RE ENVISIONED COULD BE
COSTLY BECAUSE OF A LARGE EFFORT
THAT WOULD BE PUT INTO TRY TO
ASSESS THE SCIENTIFIC GOALS
ASSOCIATED WITH THE
TRANSFORMATIVE PROJECTS SO
GETTING THEM UP AND GOING NOW
WILL ENABLE THEM TO ENJOY
ASPECTS OF THE FUNDING THAT
WOULD BE INCREASING NEXT YEAR.
SUCH A LARGE, LARGE AMOUNT.
NEXT SLIDE, PLEASE.
SO ONE OF THE REAL SUCCESSES OF
THE BRAIN INITIATIVE IS
ILLUSTRATED HERE.
IN THE OCTOBER ISSUE OF NATURE,
ALMOST THE ENTIRE ISSUE OF
NATURE WAS DEVOTED TO THE BRAIN
SELF-CENSUS INITIATIVE AND SO
THIS WAS EFFORT FUNDED BY BRAIN
WITH MULTIPLE INVESTIGATORS FROM
MULTIPLE UNIVERSITIES TO TRY TO
CHARACTER EYES INDIVIDUAL CELLS
OF THE BRAIN AND IN PARTICULAR
THIS IS THE PRIMARY MOTOR CORTEX
TO UNDERSTAND CHEMICALLY AND
MOLECULARLY HOW THESE CELLS ARE
DIS TIDISTINGUISHED FROM ONE ANR
AND THEY WILL WORK TO ELABORATE
CIRCUITS AND THIS JUST A MASSIVE
EFFORT OVER SEVERAL YEARS AND WE
SAW IT IN 11 PAPERS SUB
ACCOMPLISHED IN NATURE SO I
ENCOURAGE YOU TO GET IT ON-LINE
TO TRY TO ASSESS THIS AND LOOK
AT THE DATA GENERATED AND IT'S
PUBLICLY AVAILABLE TO YOU AS
WELL SO SHOULD YOUR RESEARCH
EFFORTS REQUIRE INFORMATION WITH
RESPECT TO THE TRANCE SCRIP OF
CELLS IN THE PRIMARY MOTOR
CORTEX OF THE MOUSE OR SO THEREE
DATASETS AVAILABLE.
NEXT SLIDE.
THIS WAS AN EFFORT.
THE ENTIRE SELF-CENSUS NETWORK
EFFORT WAS TO DEVELOP A MULTI
MODEL ANALYSIS OF THESE CELLS
AND WHAT IS MEANT BY THAT IS NOT
JUST LOOKING AT ONE ASPECT OF
THE BOYOLOGY, SAY NOT JUST MOR
FOLLOW GEE BUT RATHER THAT LOOK
AT GENE EXPRESSION AND LOOK AT
ACCESSIBILITY WHICH IS
ASSOCIATED WITH GENE EXPRESSION
AND THE DNA AND SOME ASPECTS
ALTHOUGH LIMITED ASPECTS OF THE
FUNCTION THROUGH ELECTRIC
PHYSIOLOGY AND TO TRY INFORM TO
GET A RICHER IN SIGHT INTO WHAT
THESE CELLS ARE DOING AND HOW
THEY FUNCTION.
NEXT SLIDE.
AND SO THIS WAS DONE IN SOME
HUMAN CELLS AND SOME AND
PRIMATES AND IN THE MOUSE AND
AND PANEL THERE WHERE SINGLE
CELL RNA SEEK AND IT ALLOWS YOU
TO LOOK AT CHROMATIN AND MUR
FISH AND WHICH IS FOR ASSESSING
GENE EXPRESSION AND LIMITED GENE
EXPRESSION IN CELLS AND IT
ALLOWS YOU TO COMBINE ELECTRIC
PHYSIOLOGY AND THE TRANSCRIPT
OWN AND GET DETAILS BY GOING TO
THE JOURNAL ITSELF AND THE
APPLICATION TO CELLS HAS A VERY
RICH DATA SET.
NEXT SLIDE, PLEASE.
AND THERE ARE SOME FUNDAMENTAL
INSIGHTS THAT WERE GAINED FROM
THIS EFFORT INCLUDING THE
SUGGESTION THAT THEIR PARTICULAR
CELL TYPES THAT ARE CONSISTENT
BETWEEN DIFFERENT SPECIES AND
THE QUESTION OF CELL TYPE AND
WHAT CONSTITUTES CELL TYPE IS
CONTROVERSIAL QUESTION WHAT HAS
BEEN DONE WITH RESPECT TO THIS
PARTICULAR EFFORT, IS A LOOK AT
CRAN SCRIPT OWN AND TO ELABORATE
CELL TIME AND SO THIS IS A
FOUNDATION FOR THINKING ABOUT
EVEN FINER CELL TYPE
DESIGNATIONS AND BASED UPON THIS
CHEMICAL CHARACTERIZATION.
ONE OF THE THINGS THAT'S REALLY
REMARKABLE ABOUT THIS IS THAT
THERE WERE 250 DIFFERENT
RESEARCHERS, 45 DIFFERENT
INSTITUTIONS, THREE CONTINENTS
INVOLVED IN THE COLLABORATIVE
EFFORT THAT PUT THIS EFFORT
TOGETHER.
THIS IS REAL TEAM SCIENCE AND
NIH HAS DONE THIS BEFORE IT'S
FOCUS THE RESEARCH EFFORTS FOR
THE INVESTIGATORS INVOLVED WITH
IT.
NEXT SLIDE, PLEASE.
SO IN TERMS OF THE
TRANSFORMATIVE PROJECTS THAT ARE
NOW MOVING FORWARD AS A FUNCTION
OF THE REPORT TO THE DIRECTOR
ABOUT BRAIN INITIATIVE PROGRESS,
IT'S CALLED BRAIN 2.0.
THERE'S GOING TO BE ANOTHER
COMPONENT TO THE BRAIN SO ATLAS
AND THIS ONE FOCUSES ON HUMANS
AND THERE'S ONE TO TROY TO LOOK
AT MICRO CONNECTIVITY OF CELLS
AND HOW CELLS INTERACT WITH ONE
ANOTHER WHICH OF COURSE IS
CRITICAL TO ALL OF US INTERESTED
IN BEHAVIORS AND MANY OF THE
ALCOHOL RESEARCHERS WOULD BE
INTERESTED IN THAT AND
CONTRIBUTE TO THAT EFFORT I
BELIEVE.
AND OF COURSE THERE'S THE EFFORT
TO TRY TO BE VERY PRECISE AND TO
GET TO TRY TO ASSESS
THEREBIOLOGY TO FUNCTION WITHIN
THE CIRCUITRY WHEN THEY'RE
INVOLVED.
SO, THERE HAVE BEEN REQUEST FOR
APPLICATION THAT'S HAVE GONE OUT
FOR THIS AND THERE ARE MANY MORE
REQUESTS FOR APPLICATIONS.
SOME OF WHICH WILL BE QUITE EX
CONTINUES I HAVE OVER THE COMING
YEARS AND TWO YEARS.
NEXT SLIDE, PLEASE.
AMONG SOME OF THE EFFORTS THAT
HAVE BEEN FUNDED THUS FAR, FOR
THE BRAIN CELL ATLAS, THERE ARE
SEVERAL GRANTS THAT HAVE BEEN
FUNDED AND YOU CAN SEE THE TITLE
OF THE GRANT AND THE
INVESTIGATORS ON THE RIGHT AND
PRE SESSION ATLAS TO DEVELOP
AGENCY THAT ALLOW YOU TO TARGET
CELLS AND PARTICULAR EFFORTS
ALONG THOSE LINES AND OF COURSE
AS I MENTIONED THERE WOULD BE
MANY MORE IN THE UPCOMING YEARS
THAT WILL HELP AUGMENT THESE
EFFORTS AND GET US TO WHERE WE'D
LIKE TO BE IN 2026.
NEXT SLIDE, PLEASE.
WITH RESPECT TO MAPPING BRAIN
CONNECTIVITY, NOW, THIS IS A
MASSIVE EFFORT AND OF COURSE
THIS IS WHERE WE ALL WOULD LIKE
TO GO.
I UNDERSTAND THE INDIVIDUAL CELL
AND IT'S REALLY I THINK
IMPORTANT AND I SPENT MY CAREER
DOING THIS AND HOW THOSE CELLS
INTERACT AND CELL FUNCTION AND
THERE'S AN EFFORT BASED UPON THE
TRANSFORMATIVE RECOMMENDATIONS
OF THE 2.40 COMMITTEE TO MAP
THESE CONNECTIONS ACROSS SCALES
FROM INDIVIDUALS SI SYNAPSES WIN
THE BRAIN AND AND OUR DISTRICT
AND IT'S IT'S A AND HOW LONG IT
TAKES AND ONE HAS TO GET STARTED
AND THE PROJECT AND TO MAKE
PROGRESS AND GIVEN THE SUCCESS
AND THE SELF-CENSUS PROJECT,
THERE'S A ROADMAP FOR HOW TO
THINK ABOUT DEVELOPING THIS
PROJECT AND MOVING IT FORWARD.
WE KNOW THAT THE BICCN MODEL
WORKED FOR THE SE SELF-CENSUS.
SIMILAR MODEL SHOULD WORK FOR
ASPECTS OF BRAIN CONNECTIVITY
AND THE CELL ATLAS FOR THE HUMAN
BRAIN ATLAS.
>> AND THE BRAIN INITIATIVE HAS
BEEN FUNDING OVER THE LAST
SEVERAL YEARS.
AND SO THESE ARE SOME OF THE
EFFORTS AND YOU HEAR A LITTLE
BIT MORE ABOUT THIS FROM
CHANGHAI CUI.
ALL THE RFAs ARE PUBLISHED ON
THE BRAIN INITIATIVE WEBSITE SO
YOU CAN ALWAYS GO THERE TO SEE
WHAT NEW INITIATIVES ARE BEING
INSTITUTED AND GRANTS ARE BEING
SOUGHT FOR.
NEXT SLIDE, PLEASE.
ONE OF THE IMPORTANT THINGS THAT
GEORGE MENTIONED DIVERSITY
MAKING US ALL BETTER AND MAKING
SCIENCE BETTER.
THIS IS TRUE AND THIS IS EFFORTS
TO INCREASE DIVERSITY AND
ENHANCE PERSPECTIVES ARE ON
GOING ACROSS ALL OF THEM AND
IT'S THINKING ABOUT HOW TO DO
THIS AND SO FROM IS THIS PLAN
DEVELOPED CALLED PLAN FOR
ENHANCING DIVERSE PERSPECTIVES
AND THE IDEA IS INFORM ENCOURAGE
AND IF YOU LOOK AT THE GROWN BOX
ON THE BOTTOM YOU WILL SEE THAT
FOR MANY APPLICATION THAT'S WILL
SHALL FUNDED THROUGH THE BRAIN
INITIATIVE, THERE WILL NEED TO
BE AN ACTUAL PLAN FOR ENHANCING
ASSOCIATED WITH THE GRAND AND
THIS IS ONE PUTS IN CVs AND
PUTS IN THEIR PLAN FOR DATA
DISSEMINATION AND A PLAN FOR
ENHANCING DIVERSE PERSPECTIVES
AND THIS IS REVIEWED AT THE PEER
REVIEW STAGE AND ALSO
ADMINISTRATIVELY THROUGH
PROGRAMS.
THE IDEA TO ENCOURAGE DIVERSE
TEAMS TO WORK TOGETHER AND AS
HIGHLIGHTED IN THE BOLD IN THE
FIRST PARAGRAPH, CAP TOPPIZED ON
THE DIVERSE AREAS AND IT WILL
OUT PERFORM TEAMS AND NIH HAS
SEEN THIS ACROSS THE BOARD IN
TERMS OF FUNDING AND THIS IS
JUST A MANIFESTATION OF ONE WAY
OF TRYING TO ENCOURAGE THIS TO
OCCUR IN STR THE EXTRAMURAL
COMMUNITY.
THIS PDP HAS BEEN DEVELOPING
OVER THE LAST FEW YEARS AND MANY
COMB UPON ANTS AND IT'S SPREAD
BEYOND THE BRAIN INITIATIVE AND
THERE ARE SOME INSTITUTES THAT
ARE IMPLEMENTING ASPECTS AND THE
Dr. OFFICE INITIATIVES AND
IT'S ANOTHER SINGLE CELL
ANALYSIS PROGRAM BUT FOR CELLS
OTHER THAN THE BRAIN AND SO IF A
MUTATION OF PDP FOR THOSE
PARTICULAR INITIATIVE WILL ALSO
HELP ENHANCE DIVERSITY.
THERE ARE VARIOUS GRANTS TO
SUPPORT THIS SO THAT MINORITY
SUPPORTING INSTITUTIONS AND
OTHER HSIs AND HBCUs AND A
NUMBER OF DIFFERENT ENTITIES
THAT CAN POTENTIALLY BENEFIT
FROM THIS TYPE OF PDP AND AS YOU
CAN SEE THAT THERE ARE SEVERAL
NON GRAINED INSTITUTES LISTED IN
THE LAST SENTENCE THAT ARE
BECOMING INTERESTED IN PEDP AND
IMPLEMENTING PEDP CONCEPT FOR
GRANT SUBMISSIONS.
NEXT SLIDE, PLEASE.
THE BRAIN IS SOMEWHERE SEPARATE
FROM WHAT I DISCUSSED IS THE
BRAIN INITIATIVE PROGRAMMING
STAFFING AND PEOPLE INVOLVE IN
THE BRAIN INITIATIVE WOULD LIKE
TO GET A FEEL FOR HOW BRAIN
RESEARCH IS DEVELOPING ACROSS
THE INSTITUTES, ACROSS THE
SCIENTIFIC FEELS AND JUST THE
BRAIN INITIATIVE ITSELF SO THEY
ARE STARTING TO DO LITERATURE
SEARCH USING ARTIFICIAL
INTELLIGENCE TO TRY TO IDENTIFY
AREAS OF BRAIN AND HOW THEY'RE
STUDIED AND FUNDED AND THIS IS
ESSENTIALLY A LITERATURE DATA
OTHER GRANTS SEARCH TO TROY TO
BETTER UNDERSTAND THE AREAS OF
NEUROSCIENCE THAT ARE DEVELOPING
AND WHICH ONCE ARE DEVELOPING
FASTER THAN OTHER AREAS AND THIS
WILL BE USEFUL IN HELPING GUIDE
HOW WE THINK ABOUT DEVELOPMENTAL
OF RFAs IN THE FUTURE AND
AREAS THAT ARE IN NEED OF
ADDITIONAL SUPPORT.
SO THERE ARE A NUMBER OF
WORKSHOPS THAT THE BRAIN
INITIATIVE SUPPORTS.
AND THESE ARE SOME OF THE ONCE
THAT HAVE GONE ON OVER THE LAST
YEAR OR SO AND THE IDEA OF THE
WORKSHOPS IS TO GET SOME
INSIGHTS INTO DIRECTIONS FOR THE
RESEARCH AND THEY'RE HELPFUL IN
HELPING THE BRAIN INITIATIVE
ADMINISTRATION DEVELOP THE
RFAs FOR THE RESEARCH THAT
WILL BE CARRIED OUT AND SO, THE
WORKSHOP OCCURRED IN JUNE OF
LAST YEAR AND YOU CAN FIND THE
TALKS GIVEN ON THE WEBSITE
SHOWING THERE AND THE BRAIN
INITIATIVE NEXT SLIDE, PLEASE.
AND THEN IN MARCH, THERE WAS
THIS BRAIN AND BEHAVIOR
QUANTITYTATION SYNCHRO NAIZATION
MEETING A NEW BEHAVIOR AND THEY
CONTRIBUTE TO IT AND THEN
THERE'S A BRAIN ACROSS THE
LIFESPAN WHERE AGEING AND AND
IT'S HELPED ON APRIL 18th AND
THESE ARE DONE WITH THE
INSTITUTES AND A NEW WORKSHOP
THAT WELCOME BACK TO THE
MOMENTARILY AND SO THE WORKSHOPS
ARE DONE THROUGH THE COUNCIL
WORKING GROUP BUT THERE'S A
WORKING GROUP THAT WORKS WITH
THE WORKING GROUP IT'S A
SUBDIVISION OF THE WORKING GROUP
AND THERE'S SOME MEMBERS OF THE
WORKING GROUP WHO ARE ON THIS
COMMITTEE AS WELL AS PEOPLE WHO
ARE NOT MEMBERS OF THE COUNCIL
AND ARE INTERESTED AND SO THIS
IS THE COMPOSITION OF THE
WORKING GROUP AS OF LAST MONTH I
BELIEVE.
CHRISTINE GRADY WHO IS CHIEF OF
NIH BIOETHICS IS ONE OF THE
CO-CHAIRS AND HANK GREELEY THE
PROFESSOR OF LAW AT STAND FORD
IS THE OTHER CO-CHAIR NEXT
SLIDE.
NEW ACTIVITIES INCLUDE WRITING
WHITE PAPERS ON YOUR ETIC ISSUES
ISSUES AND DEVELOPING ORGANIZE
WORKSHOPS SO THERE'S THIS ONE ON
ETHICAL CHALLENGE AND IMPLANT
AND NEURO DEVICES THAT OCCURRED
ABOUT TWO YEARS AGO AND ONE
ISING COMING UP IN MAY ON
CONTINUING RESPONSIBILITIES FOR
BRAIN CLINICAL DEVICE
IMPLANTATION SUBJECTS AND WHAT
ARE THE ITI CONTINUING REQUIREMS
FOR THE RESEARCH AND THEIR
HEALTH AND THE IS ROADMAP WITH
THE REVIEW OF THE BRAIN
INITIATIVE AND THE CONSULTS FOR
THE BRAIN INVESTIGATORS AND
SHOULD THEY COME UP AGAINST AN
ISSUE THAT NEEDS TO BE DISCUSSED
WITH RESPECT TO NEURO ETHICS,
THEN THERE ARE SUBGROUPS OF THE
NATURE OWE ETHICS COMMITTEE THAT
WILL MEET WITH THE BRAIN
INVESTIGATORS AND GRANTS WHERE
THERE'S A ETHIC FOES US IN THESE
BRGRANTS AND RO1 AND K # 99 ANDO
FOURTH.
THIS WASN'T FROM NUBE AND GEORGE
IS AN OFFICER ON THIS.
HIGH VALUE OF FOR THE BRAIN
INITIATIVE AND THEY WERE
DEVELOPED AS PART OF THIS
PARTICULAR EFFORT.
NEXT SLIDE, PLEASE.
THE BRAIN INITIATIVE AS I'VE
DESCRIBED IT IS AN NIH
INITIATIVE BUT IT'S ALSO AN
ALLIANCE WITH MANY IS OTHER
GROUPS INVOLVED WITH BRAIN
INITIATIVE AND WHO DO FUNDING
INDEPENDENT OF NIH INCLUDING
SIMONS FOUNDATION AND MANY OF
THE ENTITIES THAT YOU WOULD SEE
BELOW THE WHITE LINE ON THIS
SLIDE.
SO, THEY GET TOGETHER AND
DISCUSS BRAIN INITIATIVES
PROGRESS AND THEY HAVE PUT
TOGETHER A TOOL MAKER RESOURCE
WHERE YOU CAN ACTUALLY HAVE YOUR
TECHNOLOGY HIGHLIGHTED IN A
PUBLICATION THAT THEY PUT OUT
AND SO THIS IS ONE WAY OF TRYING
TO MAKE THE TOOLS THAT ARE PART
OF THE BRAIN INITIATIVE ARE MORE
READILY USEABLE AND ACCESSIBLE
TO PEOPLE WHO MIGHT NEED OR USE
THEM.
NEXT SLIDE, PLEASE.
I'LL TURN IT OVER TO CHANGHAI
CUI.
>> THANK YOU, JIM.
GIVEN A LARGE NUMBER OF FUNDING
OPPORTUNITIES AND RESOURCES
GENERATED OVER SEVERAL YEARS
IT'S CHALLENGING TO KEEP UP WITH
THE BRAIN INFORMATION AND
ACTIVITIES.
SO HERE I WILL BRIEFLY TALK
ABOUT HOW TO NAVIGATE THROUGH
BRAIN FUNDING OF COMMUNITIES AND
RESOURCES.
BRAIN INITIATIVE WEB SITES
PROVIDE COMPREHENSIVE
INFORMATION ABOUT SCIENTIFIC
AREAS, FUNDING OPPORTUNITIES,
RESOURCES, AND OTHER RELEVANT
INFORMATION.
FOR EXAMPLE, THE FUNDING, YOU
MAY FUND PASS THE FUNDING
OPPORTUNITIES FUNDED PROJECTS
LINKED TO ADDITIONAL INFORMATION
AT THE NIH REPORTER WEB SITES
AND THE UPCOMING INITIATIVE
CONTACTS ARE ALSO LISTED HERE.
THIS MAY BE A PARTICULARLY
USEFUL FOR THOSE WHO ARE
INTERESTED IN APPLYING BRAIN
OPPORTUNITIES.
BECAUSE WHEN YOU MAY WANT TO
KNOW WHAT KIND OF PROJECTS ARE
ALREADY FUNDED BY THE BRAIN?
AND THE RESOURCE IS PROVIDING A
SEARCHABLE PLATFORM FOR THE
RESOURCES GENERATED IN DIFFERENT
PRIORITY AREAS.
PUBLICATIONS AWARDED PROJECTS
ARE LISTED HERE.
AND THE PROGRAMS IT OVER VIEWS
EIGHT PROGRAM AREAS INCLUDING
SOUTH CENSUS NETWORK, UNDERRING
CIRCUITS, INFO MAT TICKS,
NEUROSCIENCE, PUBLIC-PRIVATE
PARTNERSHIP AND TRAINING, DESEM
ENATION AND TECHNOLOGY
DEVELOPMENT.
ADDITIONAL DETAILS ARE LINKED TO
EACH OF THESE AREAS AT THE
WEBSITE.
THE AMOUNT OF INFORMATION
PROVIDE HERE MAY BE OVERWHELMING
AND ANOTHER SIMPLE WAY TO GET UP
DATED INFORMATION IS TO
SUBSCRIBE TO BRING BLOCK.
FOR EXAMPLE, THE NEW
ANNOUNCEMENT ON THE BRAIN
INITIATIVE DIVERSITY SUPPLEMENT
WAS POSTED HERE RECENTLY.
SO, SUBSCRIBING TO BRAIN BLOCK
WILL ALLOW YOU TO BE
WELL-INFORMED ABOUT THE
UP-TO-DATE BRAIN FUNDING
OPPORTUNITY AND OTHER RELEVANT
INFORMATION.
STAFF HAVE BEEN INVOLVED IN
MARGINAL BRAIN INITIATIVE TEAMS
AND CONTRIBUTED TO A WIDE RANGE
OF BRAIN ACTIVITIES AND SO WE'RE
WELL POSITIONED TO HELP OUR
INVESTIGATORS TO BETTER
UNDERSTAND THE BRAIN
OPPORTUNITIES AND LEVERAGE FOR
THE TECHNOLOGIES FOR OUR
RESEARCH.
OVER THE PAST EIGHT YEARS, BRAIN
INITIATIVES HAVE NOT ONLY MADE
SIGNIFICANT PROGRESS IN
UNDERSTANDING OF THE BRAIN, BUT
ALSO GENERATED VALUABLE
RESEARCH.
SUCH AS THE MOLECULAR TOOLS
TECHNOLOGIES FOR MONITORING AND
MANIPULATING NEURO ACTIVITIES.
AS WELL AS LARGE DATASETS IN
NEURO PHYSICAL OWOLOGY, NEURO
IMAGING AND OTHER AREAS.
WHICH ARE STORED IN BRAIN DATA
ARCHIVES.
THIS DATA AND SOFTWARE TOOLS ARE
OPENLY ACCESSIBLE TO RESEARCH
COMMUNITIES.
RECENTLY BRAIN ALSO SUPPORTED
THE EXPANDING COLONIES AND
COORDINATING THE USE OF MARMOSET
IN RESEARCH AND THOUGH THE
AVAILABILITY OF THESE TOOLS
TECHNOLOGIES DATA AND MARMOSETS
TO THE LARGE RESEARCH
COMMUNITIES, PROVIDES AN
OPPORTUNITY FOR INVESTIGATORS TO
LEVERAGE THESE RESOURCES FOR
ALCOHOL RESEARCH.
HERE I WOULD LIKE TO HIGHLIGHT
TWO BRAIN PROJECTS.
RELEVANT TO DATA ANALYSIS AND
MARMOSET'S RESOURCE.
THE FIRST PROJECT AND THE
SECONDARY ANALYSIS OF BRAIN DATA
AND THE Is ARE MARK POTENZA
AND YIHONG ZHAO.
IT ENCOURAGES SECONDARY ANALYSIS
OF LARGE EXISTING DATA.
THIS PROJECT PROPOSES USING
OTHER ONCE AN LIT TICKS TO
UNDERSTAND BRAIN BEHAVIOR,
SCREENING ACTIVITY
RELATIONSHIPS.
AND IT WILL USE DATA TO
INVESTIGATE NATURAL SUBSTRATES
LINKED TO SCREEN MEDIA ACTIVITY
AND LEAVE DISTURBANCE AND OTHER
RELEVANT MEASURES.
THEY WILL USE OTHER ONCE
ANALYTICAL APPROACHES TO TEST
THE HYPOTHESIS THAT THEY LEAD TO
SLEEP DISCREPANCIES AND IMPACT
THE CROW DEVELOPMENT OF BRAIN
REGIONS AT A STRUCTURAL AND
FUNCTIONAL LEVELS SUCH AS CORTEX
AND GROWN STEMS -- THE NEXT
PROJECT CONCERNS THE MARMOSET
RESEARCH.
THEY HAVE A HIGHLY DEVELOPED
FRONTAL LOBE AND EXHIBIT PRIMATE
CIRCUITRY AND SOCIAL BEHAVIORS
AND THEY HAVE EMERGED AS A
PROMISING MODEL ORGANISM IN
NEUROSCIENCE.
IT SHOWS THE BRAIN SUPPORTED U25
COORDINATING CENTER FOR
COLLABORATE TIVE MARMOSET
RESEARCH AND THE CONTACT P.I. IS
DON CON RAT.
CONRAD.IT IS DATA SHARING WITH N
DATA REPOSITORY.
IT ALSO PROVIDES MARMOSET
INFORMATION AND SUPPORT TO
INVESTIGATORS WHO ARE INTERESTED
IN USING MARMOSET IN THE PROGRAM
SO THE COORDINATING CENTERS
SERVES AS THE CENTR CENTRALIZEDE
RESOURCE FOR MANAGING REQUESTS
AND PROVIDING INFORMATION.
OK.
NOW BACK TO YOU, JIM.
>>
>> THANK YOU, CHANGHAI CUI.
IT'S NICE TO SEE THE NIAAA
RESEARCHERS INVOLVED WITH THESE
EFFORTS.
THIS IS JUST A LAST SLIDE IN
CHANGHAI CUI AND I JUST WANTED
TO EMPHASIZE THERE'S A BRAIN
INITIATIVE MEETING COMING UP IN
JUNE OF THIS YEAR.
I HIGHLIGHTED THE ONE LAST YEAR
EARLIER.
BRAIN INVESTIGATORS GENERALLY GO
AND PRESENT BUT ANYONE IS ABLE
TO GO.
YOU CAN SIGN UP FOR THE MEETING
AND ATTEND.
IT'S GOING TO BE A VIRTUAL
MEETING.
AND -- ISN'T THAT RIGHT,
CHANGHAI CUI?
>> IT'S A HYBRID.
>> YOU CAN GO IN-PERSON AND
ATTEND VIRTUALLY.
YOU WILL SEE THE LATEST UPDATES
ON THE NEW TECHNOLOGIES SOME OF
WHICH LIKELY WON'T BE PUBLISHED
YET BUT GERMANE TO THE RESEARCH
YOU ARE DOING AND SO, WE
CERTAINLY ENCOURAGE YOU TO ZOOM
INTO THE MEETING AND SEE WHAT IS
HAPPENING.
THE EFFORTS OF THE BRAIN
INITIATIVE IMPACT ALL OF US AND
THE RESEARCH THAT YOU ARE DOING
IMPACTS THE BRAIN INITIATIVE AND
IT WOULD BE VERY NICE TO BE ABLE
TO HAVE MORE NIAAA RESEARCHERS
FUNDED THROUGH THE BRAIN
INITIATIVE AND TO BE EVEN
FURTHER ENGAGE SO THAT PROGRESS
CAN BE MADE JOINTLY IN
UNDERSTANDING HOW THE BRAIN
FUNCTIONS SO, WITH THAT,
CHANGHAI CUI AND I CAN TRY TO
ADDRESS ANY QUESTIONS THAT YOU
MIGHT HAVE.
I DO WANT TO EMPHASIS, CHANGHAI
CUI IS A GREAT SOURCE.
IF YOU HAVE QUESTIONS ABOUT THE
GRANTS, AND THE FOAs, SHE'S
WONDERFUL PERSON TO TALK ABOUT
THIS IN ADDITION TO GOING TO THE
WEBSITE SHE HIGHLIGHTED EARLIER.
YES, PLEASE, ANY QUESTIONS YOU
MIGHT HAVE, WE'LL TROY TO
ENTERTAIN THEM.
>> THANK YOUIN, BOTH.
THAT WAS EXCELLENT.
IT RAISED A FIE THOUGH A FEW THY
MIND.
CHANGHAI CUI AND I TRIED TO FIND
OUT WHETHER ANYONE HAD DONE
SELF-ADMINISTRATION OF ALCOHOL
IN MARMOSETS AND IT'S WIDE OPEN
YOU RESEARCHERS OUT THERE.
THERE WAS ONE ABSTRACT OUT IN
THE LITERATURE I BELIEVE,
CHANGHAI CUI, CORRECT ME IF I
GOT IT WRONG AND THAT WAS NEVER
IT.
IT NEVER GOT PUBLISHED, IS THAT
CORRECT?
>> YES, THERE ARE VERY LIMITED
PUBLICATIONS THAT ARE ALCOHOL
AND MARMOSET, ABOUT 20 YEARS AGO
THERE WAS ONE STUDY OF MARMOSET,
YES.
YOU ARE CORRECT.
>> AND THEN JIM, YOU MENTIONED
THE PEDP AND I KNOW THAT WE'VE
BEEN DISCUSSING THIS IN REGARDS
TO OUR CENTER GRANTS.
TRISH, YOU WANT TO SAY SOMETHING
ABOUT THAT OR ARE YOU OUT THERE?
>> YOU KNOW, I THINK THE BRYN
INITIATIVE HAS DONE A FANTASTIC
JOB IN LEADING THE WAY ON NOT
ONLY ENCOURAGING DIVERSITY BUT
FINDING REAL WAYS TO IMPLEMENT
IT INTO THEIR INITIATIVES AND SO
WE'RE KIND OF TAKING A PAGE OUT
OF WHAT THEY'VE DONE AND
INCLUDING LANGUAGE ON DIVERSITY
IN OUR CENTER GRANTS AND WE'LL
LOOK CAREFULLY AT THE CENTERS
THAT THEY'RE LOOKING TO
IMPLEMENT MEANINGFUL STEPS.
>> THANK YOU.
TRISH.
SO WE -- TO PUT IT SIMPLY, JIM,
WE HEAR YOU, THINKING YOU IN THE
BRED SENSE OF THE BRYN BRAIN INE
THE LAST THING IS, GIVEN THE
RICHNESS OF WHAT YOU BOTH
PRESENTED, IS IT ON OUR WEBSITE?
ARE THERE LINKS TO THE BRAIN
INITIATIVE ON OUR WEBSITE?
THAT ARE SPECIFIC ENOUGH TO HELP
NIAAA RESEARCHERS?
BECAUSE SOME OF THE LINKS THAT
THEY SHOWED IN THEIR SLIDES
WOULD BE VERY VALUABLE TO HAVE
ON A PAGE.
>> I'LL HAVE TO LOOK AT THAT, WE
CAN TAKE ANOTHER LOOK AND TRY TO
CONNECT MORE.
WE CAN DEFINITELY WORK ON THAT.
>> AND YOU HAVE A COPY OF THE
SLIDES.
I SEE A QUESTION --
>> THOSE WERE MY COMMENTS.
REALLY GOOD PRESENTATION AND
REMINDED ME OF ALL THE THINGS
THAT WE ARE INVOLVED IN WITH
BRAIN AND MANY OF THE ADVANCES
THAT THE BRAIN HAS HAD.
I KNOW THAT THIS MAY REMOTE FOR
RALPH'S DIVISION BUT YOU MAY
NEVER KNOW HOW SOME MARKER IN
THE FUTURE WILL BE USED AT THE
EPIDEMIOLOGICALLY OR FOR AN
INTERVENTION OR PREVENTION.
DAVE LOVINGER HAS A QUESTION OR
COMMENT.
>> LET ME JUMP IN.
JUST TO FOLLOW-UP ON SOMETHING
GEORGE SAID.
NOW, FOR THE CIRCUIT ANALYSIS,
THAT'S GOING ON THAT'S GOING TO
GET TREMENDOUS AMOUNT OF
FUNDING, THE BEST WAY TO THINK
ABOUT CIRCUIT ANALYSIS IS
THROUGH SOME TYPE OF PER TER
EVACUATION.
TERBATION, THEY THINK ABOUT THE
RESEARCH AND CONTEXT OF THAT
HAVE AND THERE SHOULD BE
OPPORTUNITIES FOR YOU TO BRING
THAT EXPERIENCE TO THE BRAIN
INITIATIVE SO I'M SORRY,.
>> IT'S SO GREAT.
I WAS WONDERING ARE THERE ANY
PROJECTS LOOKING AT WHAT I GUESS
GUESS I WOULD CALL SUB CELLULAR
PROTEOMICS AND I'M INTERESTING
IN WHAT IS INSIDE OF PRE SIN
ATSYNAPTIC TERMINALS?
IS THAT THING EVEN FOR
DENDRITES?
>> SHOULD I JUMP IN?
>> SURE, GO AHEAD.
>> THANK YOU.
>> NOW THAT LEVEL OF ANALYSIS,
DAVID, IS NOT PER SE FUNDED
THROUGH THE BRAIN INITIATIVE AT
THE MOMENT.
IT'S MORE CELLULAR.
WE'RE DEFINITELY GETTING THERE.
THERE ARE EFFORTS THROUGH NIAAA
AND FOR SUB CELLULAR ANALYSIS OF
PROTEIN LOCALIZATION.
I THINK IT'S A GREAT, GREAT
QUESTION AND VERY IMPORTANT.
MY GUESS IS THAT AS WE GET MORE
IN TERMS OF CELL CENSUS, IT WILL
BE EVEN MORE IMPORTANT FORT
BRAIN INITIATIVE TO GET INTO
THAT ANALYSIS SO ACTUALLY IT'S A
GOOD SUGGESTION, IF YOU DO MIND,
WHEN WE HAVE OUR NEXT BRAIN
WORKING GROUP, WHICH I THINK IS
ACTUALLY NEXT WEEK, MAYBE I'LL
BRING THAT UP AS SOMETHING TO
THINK B I THINK IT'S A GOOD
SUGGESTION FOR THAT TO
EMPHASIZE.
>> OH, YEAH, IT WOULD BE GREAT
TO BRING IT UP.
>> OK.
>> IN SOME SENSE, THE PAPER I
HIGHLIGHTED ON METABALOMIC WAS A
PROTEIN INTERACTION THIS MORNING
SO YOU KNOW, IT'S GETTING
CLOSER.
IT'S NOT SELF-SPECIFIC, IT WAS
IN THE BLOOD, BUT STILL.
WHO WOULD HAVE DREAMED IF YOU
THINK BACK 20 YEARS.
ANYWAY, OTHER THOUGHTS OR
COMMENTS, QUESTIONS?
>> YEAH, THERE ARE VERY FEW
STUDIES I'VE BEEN DOING IN THE
CELL TYPES PROTEOMICS OF MET BOL
OMICS SO WHAT DAVID LOVING GER
IS A GO AREA THAT THE BRYN MIGHT
GO FORWARD, YES.
>> YES.
>> I'M SORRY, JUST FOR ONE,
CHANGHAI CUI HAS MENTIONED THIS
BEFORE AND SHE AND I HAVE SOME
DISCUSSIONS ABOUT THIS AND SO
YES ON PEOPLE'S RADAR.
>> SO GORGE, THIS IS ANTONIO.
SO I THINK DANE MAYFIELD HAS
SOME OF THOSE EXPERIENCES IN
TERMS OF THE PRE SYNAPTIC AND AS
A SITE PROJECT WITH ONE OF THE
OUR.
>> DECIDED IN TEXAS AUSTIN AND
PART OF THE CONSORTIUM.
>> ENCOURAGE HIM TO APPLY BRAIN
INITIATIVE OPPORTUNITIES, YES.
>> CHANGHAI CUI, WE DID BUT
MAYBE IT'S TIME FOR TO YOU DO
ANOTHER PRESENTATION?
[LAUGHTER]
>> WE DID, THAT'S RIGHT.
YEAH.
>> MAYBE TAKE THOSE SLIDES AND
YOU AND JIM SHOWED AND TAKE IT
TO ENYA, I DON'T KNOW.
YOU GUYS ABOUT THIS IT.
IT'S IN YOUR DIVISION.
ANY OTHER THOUGHTS?
AGAIN, YOU KNOW, THIS IS ANOTHER
EXAMPLE -- I DON'T KNOW WHETHER
YOU NOTICED WHEN I MENTIONED THE
BUDGET THIS MORNING, BUT YOU
KNOW THERE WAS A 5.4% INCREASE
FOR NIH BUT A 3.4% INCREASE FOR
US.
ONE OF THE THINGS YOU HAVE TO
REALIZE IS THAT WE DO BENEFIT
FROM THE OVER ALL INCREASE
BECAUSE ALL OF US IS -- WE'RE
GOING TO START TAPPING INTO THAT
BUT THE BRAIN INITIATIVE IN
PARTICULAR, SO SOME OF THESE --
THERE'S A TENDENCY FOR CONGRESS
TO DO MORE DIRECTED
OPPORTUNITYING OF PROGRAMS THESE
DAYS BUT WE'RE STARTING TO GET
INVOLVED IN SOME OF THOSE
INCLUDING THE HEAL INITIATIVE
DOWN THE LINE, WE HOPE.
SO I JUST WANT YOU TO BE AWARE
THAT WHILE IT LOOKS LIKE MAYBE
WE'RE GETTING A LITTLE BIT
CHEATED OUT OF THE BIG PIE, NOT
EXACTLY, BECAUSE ALL THESE
INSTITUTES ARE BASICALLY FOR
THEIR GENERAL FUND THEY'RE
GETTING THE SAME INCREASES WE
ARE, IT'S THE MORE TARGETED
PROGRAMS THAT ARE GETTING SOME
OF THE EXTRA MONEY AND I THINK
IT'S GOING TO PAYOFF FOR THINGS
LIKE THE BRAIN INITIATIVE,
THAT'S MY GUESS.
TO SOME EXTENT, THE BRAIN
INITIATIVE IS -- IT'S GOING TO
BE MORE EFFICIENT.
IF WE TRIED TO DO THAT ON OUR
OWN AND OUR OWN INSTITUTE, YOU
KNOW, WE WOULD NEVER GET THERE
AS FAST.
RIGHT, JIM?
LIKE YOU SHOWED ON THAT SLIDE
WITH ALL THE PEOPLE WORKING
TOGETHER.
>> YEAH, NO, YOU ARE RIGHT,
GEORGE.
IT WAS A MASSIVE EFFORT AND
BRINGING ALL THOSE PEOPLE
TOGETHER TO WORK IS JUST REALLY
DIFFICULT X SO I THINK HAVING
THE OVERVIEW OF THE BRAIN
INITIATIVE TO HELP ORGANIZE
THAT, WE REALLY MADE IT A
POSSIBILITY SO YEAH, IT WOULD BE
HARD OTHERWISE.
>> YOU KNOW, JUST LOOKING BACK
WHEN I FIRST CAME, THEY JUST
GOTTEN UNDERWAY AND TOM WAS
RUNNING THIS WITH STORY LANDIS.
IT WASN'T EVEN WALTER YET.
AND GREG FARBER AND NED TELE AND
THAT WAS IT AND IT WAS THE FOUR
OF THEM AND JANUARY
JOHN
NYE REGULARLY MEETS WITH ME AND
IT ALWAYS TURNS OUT TO BE A
INTERESTING DISCUSSION SO
CHANGHAI CUI AND I MET WITH HIM
ABOUT WITH HIMAND -- CHANGHAI CN
VERY ACTIVE AND BEEN NOW INVITED
TO JOIN A COUPLE OF THE OTHER,
WHAT ARE THEY CALLED, TEAMS, AT
THE BRAIN INITIATIVE.
SO WE'RE IN THERE DOING SOME
STUFF.
MORE DOWN THE LINE SO AGAIN, IF
YOU SO MUCH, JIM AND CHANGHAI
CUI.
I THINK WE'RE GOING TO MOVE ON
TO A CONCEPT CLEARANCE ON -- I'M
ASSUMING M IS MOBILE HEALTH
INTERVENTIONS FOR UNDERSTANDING
PREVENTING ALCOHOL RELATED
DOMESTIC VIOLENCE.
ROBERT FREEMAN IS GOING TO DO
THIS.
AFTER HIS PRESENTATION, I WILL
REQUEST FOR COMMENTS,
SUGGESTIONS AND ENDORSEMENT OF
THE CONCEPT SO THIS IS A CONCEPT
CLEARANCE.
SO ROBERT, IT'S ALL YOURS.
>> OK.
>> I WANT YOU TO KNOW THAT Dr.
FREEMAN HAS BEEN OUR
REPRESENTATIVE IN THIS AREA
SINCE I STARTED AND IT IS A VERY
CHALLENGING AREA TO DO RESEARCH
IN.
I'LL JUST PUT IT THAT WAY,
RIGHT, ROBERT.
>> YES, I WOULD SAY SO.
WE HAVE THE FIRST SLIDE.
I GUESS THE SECOND SLIDE.
[LAUGHTER]
>> WELL, THE CONCEPT COMING OUT
OF OUR DIVISION, REFLECTS WITH
WHAT'S BEEN GOING ON LATELY IN
TERMS OF THE LOCKDOWN, AS A
RESULT OF COVID, AND STAY AT
HOME ORDERS AND THINGS LIKE
THAT.
AS YOU ARE PROBABLY AWARE, A LOT
OF RESEARCH HAS NOW BEEN DONE
COMING OUT THE LAST COUPLE OF
MONTHS SHOWING THAT I GUESS
ROUGHLY EQUAL AMOUNTS OF PEOPLE
INCREASE THEIR RATES OF HEAVY
DRINKING AS MUCH AS DECREASED IT
DURING THE PANDEMIC AND IF WE
CAN GENERALIZE FROM THE RESEARCH
WE SEE IN EUROPE AND THE U.S.
AT THE SAME TIME, WE HAVE SEEN
SOME WORRYING TRENDS.
FEWER PEOPLE COMING IN AS
REPORTING VICTIMIZATION FROM
DOMESTIC VIOLENCE AND I'M USING
THE DOMESTIC VIOLENCE NOW IN
THIS TO REFER TO PARTNER
VIOLENCE OR IPV AS WELL AS CHILD
MALTREATMENT AND ELDER ABUSE.
BECAUSE, YOU KNOW, A LOT OF
PEOPLE -- IT'S DETECTED BY
PRIMARY CARE DOCTORS OR TEACHERS
OR THING LIKES THAT.
PEOPLE JUST WEREN'T BEING SEEN
AND THESE THINGS WEREN'T BEING
REPORTED SO THE DOWNTURN IN
REPORTS OF VIOLENCE, IS ACTUALLY
SEEN AS A FAIRLY OMINOUS
INTERPRETED SO IT PRESENTS A
PICTURE OF PERHAPS PEOPLE
DRINKING HEAVILY AND LOCKED DOWN
WITH THEIR VICTIMIZER, AND SO IT
HIGHLIGHTS THE -- REALLY AN
APPROACH THAT IN A FEW YEARS,
PRIOR TO THE PANDEMIC, IT
STARTED FUNDING GRANTS THAT
WE'RE USING, OR HELD-HELD
APPROACHES, TO TRY TO BUILD
INTERVENTIONS AND THAT COULD BE
USED AT THE MOMENT, JUST OF IN
TIME OR ECOLOGICAL.
>> SO, IN A WEIRD WAY, THE TREND
THAT WOULD JUST START PRIOR TO
THE PANDEMIC, THE PANDEMIC
ITSELF KIND OF HIGHLIGHTED THE
IMPORTANCE OF CONTINUING WITH
THIS RESEARCH TO REACH IN TO
PEOPLE WHO ARE NOT ABLE TO
EASILY GET OUT OF THEIR
COMMISSIONS, PERHAPS.
AND, YOU KNOW, THE -- THE --
THIS IS -- SO, WE SEE THIS NO
SEE, THIS IN THE OF SPECIAL
INTEREST, AND KIND OF A FLAG.
THE DIVISION DOESN'T WANT TO SAY
WE ARE TURNING OUR BACK ON
IN-PERSON INTERVENTIONS FOR
ALCOHOL-RELATED DOMESTIC
VIOLENCE AND WE ARE WAVING A
FLAG SAYING IN-HELD ONES ARE
REALLY SOMETHING TO BE A FOCUS
NOW. WE DON'T KNOW HOW LONG
THIS PANDEMIC WILL BE HERE WITH
ALL OF THE VARIANTS IT THAT KEEP
COMING UP AND LOOKS LIKE A TREND
THAT WE WANT TO ENCOURAGE AND
ESPECIALLY BECAUSE LOTS OF
PEOPLE ARE SAYING THAT THEY
ACTUALLY LIKE THE
TECHNOLOGY-ENABLED
INTERVENTIONS.
AND FAVOR IT OVER IN-PERSON
GROUP COUNSELING AND THERAPY AND
THINGS LIKE THAT.
IT HAS ADVANTAGES THAT ARE
DELIVERING INTERVENTIONS WITH
USING CELL PHONE TECHNOLOGY.
IT CAN BE DELIVERED TO PEOPLE
WHO LIVE IN RURAL AREAS FOR ITS
GREATER PRIVACY AND LOWER COST
AND IT COULD BE AVAILABLE 24/7.
REALLY, MOST IMPORTANTLY,
POTENTIALLY, IT CAN BE DELIVERED
IN THE MOMENT IN THEORY.
AND AT THE MOMENT OF GREATEST
[INAUDIBLE].
CAN WE GO TO THE NEXT SLIDE?
SO, IN LIGHT OF THESE TRENDS,
THE PURPOSE OF THIS ANNOUNCEMENT
IS TO ADDRESS THE NEED FOR
RESEARCH FOR DEVELOPING,
TESTING, AND INTERVENING
PROXIMAL TO DRINKING OCCASIONS
AND DOMESTIC VIOLENCE TO BE
ELEVATED WITH ALCOHOL
CONSUMPTION AND LEVELS TO BE
TRIGGERED TO DOMESTIC VIOLENCE
SHOWING SKILLS REDUCED OF
VIOLENCE PERPETRATION AND
[INAUDIBLE] SPECIFICALLY.
OF SCALEABLE LOW RESOURCE AND
REMOTELY DELIVERED INTERVENTIONS
AND MOBILE DEVICES RELYING ON
COMMUNICATION TECHNOLOGIES
REDUCING AND PREVENTING ALCOHOL
CONSUMPTION AND VIOLENCE AND
TERM, AS I SAID, ABUSING
DOMESTIC VIOLENCE HERE IS A TERM
TO COVER NOT JUST I
TEST.
>> AS A WAY OF DISSEMINATING
INFORMATION AND BE AN EFFECTIVE
BYSTANDARD IN A POTENTIAL SEXUAL
ASSAULT SITUATION AND WE HAVE
PACKAGES THAT CAN BE GIVEN TO
INCOMING FRESHMAN IN THE WEEK
BEFORE SCHOOL BEGINS AND
UNIVERSAL PREVENTION TECHNIQUE
THAT THEY CAN LEARN ABOUT
DRINKING AND SEXUAL ASSAULT AND
BEING AN EFFECTIVE BYSTANDARD.
BUT, WHEN IT COMES TO INTIMATE
PARTNER VIOLENCE, THE
IMPLEMENTATION, IF YOU HAD AN
EFFECTIVE INTERVENTION HOW TO
IMPLEMENT IS A BIG QUESTION.
YOU ARE TRYING TO GET INTO THE
DIAD. THERE IS A LOT OF ROOM
FOR THINKING HERE THAT YOU COULD
HAVE SOMETHING THAT PERHAPS
PEOPLE -- INTERVENTION IT THAT
YOU COULD ACCESS AT HOME AND YOU
COULD ACCESS A WEBSITE LIKE
PRIMARY CARE WOMAN'S WELLNESS
CENTER AND COMMUNITY ALCOHOL
CLINIC TREATMENT CENTER OR
SOMETHING LIKE THAT AND
TELEHEALTH WITH AN ACTUAL
COUNSELOR AT THE END AND THERE
IS ALL SORTS OF POSSIBILITIES
FOR IMPLEMENTING AND BUILDING
THE INTERVENTION AND PUTTING IT
THERE YOU A PHASE 3 TRIAL AND
EFFICACY AND TO IMPLEMENT, THIS
IS A BIG PROCESS THAT WE ARE
SORT OF IN THE MIDDLE OF IT.
AND THAT IS KIND OF WHAT WE ARE
CALLING FOR HERE.
AGAIN, I WANT TO EMPHASIZE YOU
ARE NOT TURNING YOUR BACK ON
IN-PERSON INTERVENTIONS AND THE
LAST SLIDE, I THINK IS -- THE
OUTCOME IS TO ADVANCE, AGAIN,
THE DEVELOPMENT AND FEASIBILITY
AND PRIVATE TESTING POTENTIAL
EFFICACY AND SCALE RESOURCE AND
REMOTELY DEAL WITH INTERVENTIONS
AND TECHNOLOGIES PRODUCING
ALCOHOL TRIGGERED DEPENDENT
DOMESTIC VIOLENCE AND ONE MORE
SLIDE WITH A QUESTION FROM DR.
CHAMBERS WHO SAYS IF WE CAN HAVE
AN INCLUSION OF PREGNANT AND
POSTPARTUM INDIVIDUALS WITH
POPULATION AND ELEVATED RISKS
AND IT IS A POINT WELL TAKEN AND
THERE IS OTHER GROUPS AND
CERTAINLY YOU WILL INCLUDE THAT
AND OTHER GROUPS THAT WE CAN
THINK ABOUT FOR RESEARCH AND
THOSE POPULATIONS.
SO, THAT IS THE -- OUR DIVISIONS
CONCEPT PLANS.
>> WELL, THANK YOU VERY MUCH,
ROBERT.
THAT WAS GREAT.
I THINK YOU HAVE COVERED ALL OF
THE GROUND.
I WILL OPEN IT UP FOR
DISCUSSION.
YOU KNOW, I -- I BELIEVE THAT
THE -- IF THERE IS A REMOTE
SILVER LINING, PUN INTENDED, TO
THE PANDEMIC, IT IS THAT SOME OF
THE INTERVENTIONS -- SOME OF THE
METHODS ARE GOING TO BE -- YOU
KNOW, THERE WILL BE SURVIVAL OF
THE FITTEST AND SURVIVAL OF THE
BEST.
WE WILL START TO SEE SOME
DEFINITE USEFULNESS THERE.
SO, KATIE HAS HER HAND UP FIRST
AND THEN JILL.
>> HI. THANKS SO MUCH. I'M
REALLY EXCITED ABOUT THIS WORK
AND JUST WANTED TO EXPAND THE
CONTENT BEYOND JUST COMMUNITY
COLLEGE STUDENT AND ALSO
THINKING ABOUT STUDENTS EVEN AT
FOUR-YEAR COLLEGES THAT ARE
NON-RESIDENTIAL AND THAT TEND TO
ALSO HAVE OLDER AGES AND TEND TO
BE PARTNERED RELATIONSHIP.
SO, JUST INCLUDING THAT MORE
INCLUSIVE LANGUAGES OF STUDENTS
ACROSS THE COLLEGE SPECTRUM.
>> THANK YOU, KATIE. YES.
OKAY.
>> JILL?
>> YEAH. I WANTED TO JUST
MENTION THAT I SAW BERN ADEAN
WALLER SPEAK LAST WEEK AT A
CONFERENCE AND AFRICAN AMERICAN
WOMEN ARE 5 TIMES MORE LIKELY TO
BE MURDERED AND INTIMATE PARTNER
VIOLENCE THAN WHITE WOMEN AND WE
NEED TO MAKE SURE IS THERE A
TENSION TO RACIAL MINORITIES NO
THE JUST COMMUNITY COLLEGE
STUDENTS THAT I DON'T KNOW HOW
TO PUT IT IN LANGUAGE THAT SEEMS
LIKE IT IS A VERY SERIOUS
PROBLEM IN THE AFRICAN-AMERICAN
COMMUNITY.
>> THAT IS TRUE.
I MEAN, YOU POINTED OUT
SOMETHING THAT IS TRUE.
THE PORTFOLIO TENDS TO BE FOR
IPV THAT IT TENDS TO BE WHITE
COUPLES.
YEAH.
THAT IS A VERY IMPORTANT THING.
>> YEAH. I CONCUR COMPLETELY.
I THINK THIS IS AN OPPORTUNITY
TO EXPAND INTO THOSE DOMAINS
THAT WE HAVE NEGLECTED, TO BE
HONEST.
OTHER THOUGHTS OR COMMENTS OR
QUESTIONS?
>> SO, ABE, HOW DO WE DO THIS?
DO WE --
>> IF YOU CAN ASK ANY OF THE
COUNCIL MEMBERS THAT WOULD LIKE
TO ENDORSE THE CONCEPT.
>> SO, ANYONE WANT TO VOLUNTEER
TO ENDORSE THE CONCEPT?
DO WE NEED TO VOTE, ABE?
>> NO. A VOTE IS NOT NECESSARY.
>> WE NEED ENDORSEMENTS.
>> I ENDORSE.
>> IT IS AN ENDORSEMENT.
>> OKAY. IS THAT -- ARE WE
GOOD, ABE?
>> WE ARE GOOD.
>> ALL RIGHT. WELL, THANK YOU
VERY MUCH.
SO, NOW WE MOVE ON TO EXOFISHIO
REPORTS AND WE HAVE NOW CAUGHT
UP WITH OURSELVES SO ARE ON
SCHEDULE.
>> NO REPORT FROM DOD. I GOT A
REPORT FROM DR. MILLICAN. WE
CAN CONTINUE WITH COUNCIL
DISCUSSION.
>> OKAY. IT IS NOW WIDE OPEN
FOR COUNCIL DISCUSSION FROM
ANYONE ABOUT ANYTHING.
YOU KNOW, I'M TRYING TO THINK IF
THERE IS ANYTHING I WOULD REALLY
LIKE YOUR INPUT ON.
YOU KNOW, I WILL LEAVE THE HPCR
AS YOUR HOMEWORK, SO-TO-SPEAK,
TO LOOK AT THAT WEBSITE AND SEE
IF YOU HAVE THOUGHTS OR COMMENTS
OR ADDITIONS OR SUBTRACTIONS OR
-- AND PLEASE SPREAD THE WORD
THAT IT IS AVAILABLE AND, YOU
KNOW, THERE MIGHT BE OTHER
THINGS THAT WE CAN SPIN OFF
FROM.
THE HEALTH PROFESSIONALS CORE
RESOURCE.
WHILE WE ARE WAITING TO SEE IF
ANYBODY HAS ANYTHING TO DISCUSS,
TRISH, PATRICIA POWELL, DEPUTY,
DO YOU HAVE THOUGHTS OR THINGS
THAT WE MIGHT HAVE MISSED THIS
COUNCIL THAT WE HAVE ALL BEEN
DISCUSSIONING AT AAA?
>> GEORGE, DIFFERENT PEOPLE
BROUGHT IT UP BUT TO REITERATE
THAT A MAJOR PRIORITY IS
DIVERSIFYING THE WORKFORCE AND
GETTING COLLABORATION INVOLVING
DIVERSE PARTICIPANTS AND DEALING
WITH HEALTH DISPARITIES AND
QUESTION AND CONCEPT CLEARANCE
AND BRAIN LANGUAGE THAT I WILL
RE-ENFORCE THAT BUT JUST IN CASE
WE NEED TO CALL IT OUT, KNOW
THAT, THAT IS A TOP PRIORITY
THAN ON AAA THAT WILL BE HIGHLY
REPRESENTED IN THE STRATEGIC
PLAN AS WELL.
>> YEAH. I ALWAYS LOVED PUTTING
BRIDGET ON THE SPOT.
SO, ONE MORE TIME, BRIDGET,
WHERE ARE WE AT WITH STRATEGIC
PLAN FOR THE COUNCIL? YOU DON'T
HAVE TO GET SPECIFIC.
>> IT IS STILL UNDER DEVELOPMENT
AND WE ARE FOCUSED ON WRITING
ACTUAL CHAPTERS THAT WE HAVE A
PRELIMINARY DRAFT THAT WE ARE
WORKING WITH.
SO, OUR -- WE ARE JUST
CONTINUING TO TURN AND WORK AND
GET IT DONE AND GOAL IS TO HAVE
IT DONE BY THE FALL OF THIS
YEAR.
>> GOOD. WE ARE GOING TO BE --
THAT WILL BE YOUR FUTURE
HOMEWORK.
ABE, SINCE I'M JUST FREE
THINKING HERE, NEXT COUNCIL, ARE
WE DOING IT HYBRID, VIRTUAL, OR
SOME -- OR WHAT? DO WE KNOW
YET?
ARE WE JUST GOING TO BASICALLY
PLAY IT BY EAR DEPENDING HOW
THINGS EVOLVE?
>> WE CAN PLAY IT BY EAR
DEPENDING ON NUMBER OF COUNCIL
MEMBERS THAT WOULD LIKE TO COME
IN PERSON.
SO FAR, I ONLY HAVE TWO WHO PLAN
TO ATTEND.
A THIRD ONE IS A TENTATIVE
DEPENDING ON THE NUMBER OF
COUNCIL MEMBERS THAT WOULD LIKE
TO TRAVEL TO WASHINGTON, DC.
SO, BUT FOR STAFF, I THINK WE
CAN STILL DO A HYBRID.
PEOPLE WHO ARE IN THE BUILDING
CAN JOIN US IN CONFERENCE ROOM
A, B, AND C.
>> YEAH. SO, WE ARE JUST GOING
TO SEE HOW IT WORKS.
RIGHT NOW I HAVE ATTENDED SOME
OF YOU KNOW I HAVE ATTENDED TWO
INSTITUTE DIRECTOR MEETINGS
RECENTLY THAT WERE HYBRID.
THEY SORT OF WORK. OKAY SOME.
I MEAN, IN THE LAST ONE, JUST TO
BE HONEST WITH YOU, YOU KNOW,
ONE OF MY COLLEAGUES WHO IS
VIRTUAL STARTED TO RIFF ON A
QUESTION AND ENGAGED ANOTHER
COLLEAGUE WHO WAS VIRTUAL AND
NOBODY IN THE ROOM COULD GET
THEM TO STOP.
AND SO IT WAS A LITTLE BIT
AMUSING. I WON'T MENTION THE
NAMES, BUT THEY ARE FAMOUS
PEOPLE THAT YOU ALL KNOW.
AND, YOU KNOW, BASICALLY, WHAT
WAS HAPPENING WAS THERE WAS SOME
DISCONNECT.
SO, THE PEOPLE IN THE ROOM, I
WAS IN THE ROOM WITH LARRY TEBAC
AND DEANNA BIANCA WAS SITTING
NEXT TO ME AND WE COULDN'T GET
THEM TO HEAR US AND CHALLENGES
REMAIN ON SOME OF THESE THINGS
AND ON OTHER HAND I HAVE BEEN ON
SPECTACULARLY GOOD HYBRID
MEETINGS AND ONE IN FRANCE THAT
MY STAFF IS SICK OF HEARING
ABOUT BUT BASICALLY I WAS LIKE
THERE IN PERSON BUT I WASN'T.
YOU KNOW, I WAS VIRTUAL. THEY
HAD A MICROPHONE AND MAYBE A
CAMERA MAN AND THAT IS HOW THEY
DID T IT, A CAMERA PERSON AND ON
ZOOM AND ASKING QUESTIONS AND
WALKED AROUND WITH A MICROPHONE
AND I FELT I WAS RIGHT IN THE
ROOM WITH THEM AND DEPENDS ON
THE PLATFORM AND HOW THESE
THINGS EVOLVE AND HOW IT GOES
AND WANT YOU TO KNOW WE ARE
BEING FLEXIBLE ON ALL FRONTS IN
THIS REGARD AND SO IS NIH AND WE
WILL JUST SEE HOW THINGS EVOLVE.
ALL RIGHT. ANY OTHER THOUGHTS
OR QUESTIONS OR COMMENTS? HAVE
WE EXHAUSTED EVERYTHING? SCOTT
AS A QUESTION. SCOTT?
>> YOU PULLED IT OUT OF ME WITH
HYBRID IN-PERSON DISCUSSION.
MORE IMPORTANTLY THOUGH IS THERE
ANY DISCUSSION AROUND STUDY
SECTIONS?
I THINK COLLEAGUES THAT ARE ON
STUDY SECTIONS HAVE COMPLAINED
THAT THE HYBRIDS OR VIRTUAL
FORMATS ARE NOT AS RICH IN TERMS
OF DISCUSSION POINTS AS THEY
USED TO BE.
>> YEAH. I THINK -- CORRECT ME
IF I'M WRONG, BUT TRISH AND ABE,
BUT I BELIEVE THAT NONI BURNS IS
THE HEAD OF CSR AND BELIEVE SHE
ANNOUNCED 1/3 OF THE STUDY
SECTIONS WILL BE IN PERSON?
>> I BELIEVE 1/3 OF THE STUDY
SECTIONS.
>> THIS FALL. SHE WILL FLOAT IT
OUT AND SEE HOW IT GOES, SCOTT.
>> THAT IS GREAT. FANTASTIC.
THANKS.
>> BY THE WAY, SHE DOES A
FABULOUS JOB WITH CSR FOR YOU
LIVING IN THE REAL WORLD WHO
MIGHT NOT AGREE SOME THINGS ARE
ON THE HORIZON THAT WILL MAKE IT
BETTER. WE WILL SEE AND GET TO
IT.
THERE IS ONE OTHER ANNOUNCEMENT
I WANT TO MAKE AND WILL SEE IF
THERE IS QUESTIONS FOR THE
MOMENT THAT WILL MAYBE STIMULATE
SOME QUESTIONS.
AS PART OF THE 2022 CONSOLIDATED
AUTHORIZATIONS ACT, WHICH IS
BASICALLY OUR BUDGET.
THERE WAS A CHANGE IN POLICY
THAT WHEN INDIVIDUALS IT THAT
IDENTIFIED AS A PRINCIPLE
INVESTIGATOR OR KEY PERSONNEL IN
NIH NOTICE OF REMOVED IN
POSITION OR OTHERWISE
DISCIPLINED DUE TO CONCERNS
ABOUT HARASSMENT, BULLYING,
RETALIATION, OR HOSTILE WORK
CONDITIONS, THAT HAS TO BE
REPORTED TO NIH.
SO, I'M NOT SURE IF YOU CAUGHT
THAT.
WHAT IT MEANS IS THAT IN THE
PAST WHEN SOMEONE WAS FIRED FROM
UNIVERSITY X, THEY COULD GO
UNIVERSITY Y AND EVEN RESUBMIT
GRANTS EVEN THOUGH THEY WERE
FIRED FROM UNIVERSITY X BECAUSE
OF SEXUAL HARASSMENT OR
BULLYING. ALL RIGHT?
BUT, NOW, AND WE ACTUALLY HAD
ONE OF THOSE INCIDENTS AT NIAAA.
NOW, THOSE INDIVIDUALS ARE --
THAT SITUATION HAS TO BE
REPORTED TO NIH.
YOU KNOW?
I'M NOT GOING TO -- I MEAN, IT
ACTUALLY -- SOME OF THE STAFF AT
NIH WERE TROLLING THROUGH
NEWSLETTERS OF UNIVERSITIES TO
FIND AND ALUMNI NEWS TO FIND
OUT, YOU KNOW, ABOUT BY ANOTHER
WERE ALLEGED TO HAVE PUNISHMENT
FOR ONE OF THESE KINDS OF ISSUES
BUT IT WAS ACTUALLY PUT INTO THE
LEGISLATION AT THE URGING OF
NIH.
SO, NOW NIH IS REQUIRED, YOU
KNOW, OF INSTITUTIONS THAT ARE
RECEIVED NIH FUNDING ARE
REQUIRED TO REPORT SOMEONE WHO
HAS BEEN PUNISHED FOR SUCH
ACTIVITIES.
THERE IS USUALLY, YOU KNOW, A
RESTRICTION ON THEIR ABILITY TO
APPLY FOR GRANTS IF IT IS INDEED
THE GRANT MECHANISM FOR WHICH
THEY ARE ADMINISTERING
HARASSMENT OR SEXUAL HARASSMENT
OR BULLYING OR WHATEVER.
THIS JUST CAME OUT TODAY.
AND, YOU KNOW, THE REST OF IT
GOES PREVIOUSLY NIH LACKED CLEAR
AUTHORITY TO REQUIRE FUNDED
INSTITUTIONS TO REPORT WHETHER
NIH OR TO REPORT TO NIH WHETHER
PERSONNEL CHANGES IN NIH SPAN
RELATED TO HARASSMENT ONLY THAT
THEY SHOULD REPORT IT.
NOW IT IS REQUIRED.
YOU KNOW, I HOPE THIS WILL --
YOU KNOW, I MEAN, INSTITUTIONS
GET THE GRANTS.
YOU ALL KNOW THAT?
YOU ARE ON COUNCIL AND ARE
VETERANS AND GRANTS DON'T GO TO
THE PERSON BUT GO TO THE
INSTITUTION.
WHEN AN INDIVIDUAL GETS FIRED
FOR BULLYING, THEY KEEP THE
GRANT.
THEY ASSIGN ANOTHER PERSON TO
THE GRANT.
BUT, AS I SAID, IN THE PAST, IT
THAT PERSON WHO GOT FIRED COULD
THEN GO TO ANOTHER UNIVERSITY
AND NOT DISCLOSE HIS PREVIOUS
PROBLEMS AND APPLY FOR GRANTS
AND GET BACK INTO REPEATING THE
SAME KIND ISSUES AND IS WHY THIS
WAS INSTITUTED.
THAT IS HOT OFF THE PRESS AND
CAME OUT TO AN E-MAIL TODAY OUT
OF ALL OF NIH.
SO, ANYWAY, YOU KNOW, WE DON'T
TOLERATE ANY KIND OF BULLYING OR
HARASSMENT.
YOU KNOW, YOU MAY SAY, WELL, IT
DOESN'T REALLY HAPPEN ANYMORE.
WELL, IT DOES.
I'M NOT GOING TO MENTION
INCIDENTS, BUT SOME OF YOU KNOW
I HAVE A LABORATORY AT NIGHT.
ONE OF MY POST BACCALAUREATE
FELLOWS GAVE A POSTER AT A
MEETING.
THEY WERE, YOU KNOW, BASICALLY
SHAMED.
THEY CAME BACK AND STARTED TO
CRY AND CAME BACK, YOU KNOW,
COMPLETELY DEVASTATED.
SO, YOU KNOW, I -- I WROTE TO
THE ORGANIZERS AND THEY PROMISED
IT WOULDN'T HAPPEN AGAIN AND
JUDGES WERE MAKING FUN OF HER
POSTER THAT WAS A POSTER I MIGHT
ADD IT THAT WAS SUPERVISED BY
TWO INSTITUTE DIRECTORS, MYSELF
AND NORVOKOFF AND IT DOES HAPPEN
AND I TOLERATE IT AND OUR
INSTITUTE WON'T TOLERATE IT AND
WE SHOULDN'T BE TOLERATING IT
ANYWHERE.
I COULD REGALE YOU OF ALL KINDS
OF STORIES IN MY CAREER IN THESE
SITUATIONS AND I'M SURE WOMEN
COULD REGALE ME WITH EVEN MORE
STORIES.
IT IS A SERIOUS ISSUE NOT TO
MENTION THOSE OF YOU FROM OTHER
BACKGROUNDS.
YOU KNOW, IT -- I HATE TO KIND
OF CLOSE US OUT ON A -- ON A
NEGATIVE NOTE, BUT I WANT YOU TO
JUST REALIZE THAT, I MEAN, TRISH
AND I WENT TO -- WELL, WHAT DO
THEY CALL A TOWN HALL MEETING, I
GUESS?
>> LISTENING SESSION, YEAH.
>> LISTENING SESSION. WE CAME
BACK SHAKEN.
I MUST SAY WHAT THE WOMEN
REPORTED FROM INTERACTIONS WITH
SCIENTISTS.
PARTICULARLY THE ONES THAT
HAPPENED WITHIN OUR OWN
INTRAMURAL PROGRAM AT NIH AND
DON'T KNOW WHETHER YOU CAN
DESCRIBE IT ANY DIFFERENTLY,
JUDGE.
I THINK BOTH OF US WERE LIKE --
YOU KNOW, SHAKEN IS THE WORD I
USE.
>> AND J- JUST, GEORGE, TO
REITERATE WHAT YOU SAID WE HAVE
OBSERVED AND BEEN TOLD ABOUT
BULLYING AND NOT JUST SEXUAL
HARASSMENT OR IT IS NOT
ACCEPTABLE AND WE ARE LOOKING TO
GROW PEOPLE AND MAKE SURE A
FEATURE AND SUCCESSION PLAN AND
LAST THING WE WANT TO DO IS TURN
ANYONE AWAY.
>> YEAH.
>> ALL RIGHT. ABE, WANT TO TELL
US ABOUT THE NEXT MEETING
BESIDES DOING THE VIRTUAL OR
HYBRID SOME DAY IN THE FUTURE OR
WHATEVER DAY?
>> IT COULD BE A HYBRID.
WE WILL SEE WHAT WILL HAPPEN.
I WANTED TO REMIND COUNCIL
MEMBERS IF THEY HAVEN'T VOTE
TODAY APPROVE THE COUNCIL
MEETING FOR FEBRUARY 10 MEETING
COULD YOU PUT IT IN THE CHAT BOX
OR YOU CAN RAISE YOUR HAND.
WE ARE SEEING VOTES NOW AND
WHILE GETTING VOTES, I WOULD
LIKE TO ANNOUNCE FUTURE MEETING
DATES FOR 2022 WE WILL MEET
SEPTEMBER EIGHTH AND WILL BE THE
LAST MEETING OF THE YEAR AND IN
2023, WE WILL MEET ON FEBRUARY
9, MAY 9, SEPTEMBER 7TH. IN THE
YEAR 2024, WE WILL MEET ON
EIGHTH OF FEBRUARY, MAY 7,
SEPTEMBER 12.
IN 2025, WE WILL MEET ON
FEBRUARY 6TH, MAY 6TH, AND
SEPTEMBER ELEVENTH.
FOR THE CRIME MEETING, WE WILL
HAVE THE MEETING TOMORROW.
FOR NEXT YEAR, WE WILL MEET ON
MAY 10, 2023, MAY 8, 2024 AND
MAY 7, 2025. THANK YOU.
>> OKAY. ANY QUESTIONS OR
COMMENTS? RHONDA, DID YOU HAVE
SOMETHING YOU WANTED TO SAY?
NO?
ANYONE ELSE HAVE ANY THOUGHTS OR
FINAL WORDS? OTHER THAN YOU ARE
TIRED OF HEARING FROM ME AT THIS
POINT.
>> ACTUALLY ON TIME, GEORGE.
>> WE ARE ON TIME?
>> ALL RIGHT.
>> WELL.
>> 4:42.
>> SO, I WILL GIVE YOU -- WE HAD
A 5:30 ADJOURNMENT.
>> YEAH.
>> WE WILL STOP EARLY.
I CERTAINLY HAD A GREAT TIME
HERE LISTENING TO ALL OF THE
THINGS GOING ON.
I HOPE YOU DID TOO.
WE WILL SEE YOU NEXT TIME.
>> WELL, ACTUALLY, TOMORROW,
GEORGE.
>> WE WILL SEE YOU ALL TOMORROW.
I FORGOT.
I HAD ANOTHER TALK TO GIVE
TOMORROW.
PART OF MY TALK TOMORROW WILL BE
A REPEAT OF TODAY.
SOME OF YOU CAN SLEEP THROUGH
THAT, IF YOU WANT.
I WILL INTRODUCE THE HEALTH
PROFESSIONALS AND CORE RESOURCE
SAME AS I DID TODAY AND WE WILL
TALK ABOUT, YOU KNOW, SOME
THINGS WE ARE DOING IF IN
CLOSING THE TREATMENT GAP AND
WHERE WE THINK SOME EMPHASIS
SHOULD BE AND SOMETHING WORTH
THINKING ABOUT FOR ALL OF YOU AS
WELL THAT YOU CAN HELP US IN
THAT ENDEAVOR.
I WILL LEAVE YOU WITH THAT.
HAVE A GOOD EVENING. I WILL SEE
YOU ALL TOMORROW AND THANK YOU
FOR REMINDING ME.
>> [LAUGHING].
>> THANKS, EVERYONE.
>> THE MEETING TOMORROW IS AT 11
O'CLOCK.
I WILL OPEN THE ZOOM MEETING AT
10:30.
>> OKAY. 11 O'CLOCK TOMORROW.