1 00:00:05,800 --> 00:00:08,440 >>WE'RE GOING 2 00:00:08,440 --> 00:00:10,400 TO TRANSITION NOW TO OUR OPEN 3 00:00:10,400 --> 00:00:11,880 SESSION. 4 00:00:11,880 --> 00:00:16,960 THIS SESSION IS AGAIN 5 00:00:16,960 --> 00:00:17,800 VIDEOCAST SO MEMBERS OF THE 6 00:00:17,800 --> 00:00:19,640 PUBLIC WILL BE ABLE TO VIEW 7 00:00:19,640 --> 00:00:23,160 THIS PARTICULAR PART OF THE 8 00:00:23,160 --> 00:00:23,480 SESSION. 9 00:00:23,480 --> 00:00:25,720 WE HAVE -- BEFORE I TURN IT 10 00:00:25,720 --> 00:00:27,920 OVER TO Dr. HODES TO START 11 00:00:27,920 --> 00:00:30,480 US OFF, I JUST LIKE TO DO A 12 00:00:30,480 --> 00:00:33,000 QUICK ROLL CALL OF OUR COUNCIL 13 00:00:33,000 --> 00:00:33,600 MEMBERS. 14 00:00:33,600 --> 00:00:36,640 AND AS I CALL YOUR NAME, IF 15 00:00:36,640 --> 00:00:38,560 YOU COULD PLEASE JUST GIVE 16 00:00:38,560 --> 00:00:41,360 YOUR FULL NAME AND AFFILIATION 17 00:00:41,360 --> 00:00:44,840 AND FOR THE BENEFIT OF THOSE 18 00:00:44,840 --> 00:00:49,600 LISTENING ONLINE. 19 00:00:49,600 --> 00:00:51,360 ALL RIGHT. 20 00:00:51,360 --> 00:00:55,400 SO YOU CAN START OFF WITH 21 00:00:55,400 --> 00:00:58,480 Dr. ASANA. 22 00:00:58,480 --> 00:01:01,000 >>SA NJE ASANA FROM WISCONSIN 23 00:01:01,000 --> 00:01:03,320 IN MANAGEMENT. 24 00:01:03,320 --> 00:01:03,800 >>DOCTOR BAKER? 25 00:01:03,800 --> 00:01:06,120 >>MAYO CLINIC -- 26 00:01:06,120 --> 00:01:06,560 [INDISCERNIBLE] 27 00:01:06,560 --> 00:01:07,960 >>Dr. KING? 28 00:01:07,960 --> 00:01:11,520 >>ANN KING, PRINCE TON 29 00:01:11,520 --> 00:01:15,040 UNIVERSITY. 30 00:01:15,040 --> 00:01:16,600 >>AND Dr. PHILIBERTO? 31 00:01:16,600 --> 00:01:23,000 >>CAREGIVER AND FAMILY 32 00:01:23,000 --> 00:01:29,840 REPRESENTATIVE. 33 00:01:29,840 --> 00:01:32,120 >>Dr. CRUZ? 34 00:01:32,120 --> 00:01:32,600 [INAUDIBLE] 35 00:01:32,600 --> 00:01:35,280 >>Dr. HOLONG IS NOT PRESENT 36 00:01:35,280 --> 00:01:38,560 TODAY, REVEREND DOCTOR HUMMEL. 37 00:01:38,560 --> 00:01:40,640 >>CYNTHIA HUMM ENGINE L, 38 00:01:40,640 --> 00:01:43,600 REPRESENTING THOSE LIVING WITH 39 00:01:43,600 --> 00:01:47,440 ALZHEIMER'S AND RELATED 40 00:01:47,440 --> 00:01:48,360 DEMENTIAS. 41 00:01:48,360 --> 00:01:50,400 >>Dr. INOUE? 42 00:01:50,400 --> 00:01:56,200 >>YES, Dr. INOUE, HARVARD 43 00:01:56,200 --> 00:02:02,280 MEDICAL SCHOOL, MASSACHUSETTS. 44 00:02:02,280 --> 00:02:03,080 >>Dr. CAHN? 45 00:02:03,080 --> 00:02:03,560 [INAUDIBLE] 46 00:02:03,560 --> 00:02:08,680 >>THANK YOU, Dr. LONGO? 47 00:02:08,680 --> 00:02:14,120 >>FRANK LONGO, DEPARTMENT OF 48 00:02:14,120 --> 00:02:19,400 AOURLG, STANFORD UNIVERSITY. 49 00:02:19,400 --> 00:02:24,960 >> Dr. LUNDEBERG? 50 00:02:24,960 --> 00:02:27,600 >>Dr. LUNDEBERG -- 51 00:02:27,600 --> 00:02:29,200 [INAUDIBLE]. 52 00:02:29,200 --> 00:02:31,320 >>Dr. PETERSON? 53 00:02:31,320 --> 00:02:31,720 [INAUDIBLE] 54 00:02:31,720 --> 00:02:34,840 >>Dr. RUBEN? 55 00:02:34,840 --> 00:02:38,520 >>DAVID RUBEN, SCHOOL OF 56 00:02:38,520 --> 00:02:39,760 MEDICINE AT UCLA. 57 00:02:39,760 --> 00:02:41,920 >>Dr. SNYDER? 58 00:02:41,920 --> 00:02:43,760 >>FELIX SCHNEIDER, UNIVERSITY 59 00:02:43,760 --> 00:02:46,120 MEDICAL CENTER. 60 00:02:46,120 --> 00:02:51,280 >>AND ONLINE WE HAVE DAVID 61 00:02:51,280 --> 00:02:51,560 WEIR? 62 00:02:51,560 --> 00:02:54,680 >>DAVID WEIR, UNIVERSITY OF 63 00:02:54,680 --> 00:02:55,040 MICHIGAN. 64 00:02:55,040 --> 00:02:56,880 >>ALL RIGHT, AND I THINK 65 00:02:56,880 --> 00:03:02,840 THAT'S -- OH, I AM SORRY, 66 00:03:02,840 --> 00:03:03,200 LINDA. 67 00:03:03,200 --> 00:03:07,240 >>LINDA VANELL, UNIVERSITY OF 68 00:03:07,240 --> 00:03:07,640 KENTUCKY. 69 00:03:07,640 --> 00:03:09,720 >>SUSAN GREEN SPOILED SPAN, 70 00:03:09,720 --> 00:03:14,680 UNIVERSITY OF PITTSBURGH. 71 00:03:14,680 --> 00:03:15,480 >>APOLOGIES FOR THAT. 72 00:03:15,480 --> 00:03:17,200 OKAY TO THIS OFFICIALLY STARTS 73 00:03:17,200 --> 00:03:20,880 THEN OUR OPEN SESSION OF THE 74 00:03:20,880 --> 00:03:21,560 149TH NATIONAL ADVISORY 75 00:03:21,560 --> 00:03:23,320 COUNCIL ON AGING AND I WOULD 76 00:03:23,320 --> 00:03:24,600 LIKE TO WELCOME EVERYONE AND 77 00:03:24,600 --> 00:03:27,360 TURN THE MEETING OVER TO OUR 78 00:03:27,360 --> 00:03:37,400 CHAIR, Dr. RICHARD HODES. 79 00:03:37,400 --> 00:03:40,280 >>WELL, WELCOME ALL TO THE 80 00:03:40,280 --> 00:03:41,960 OPEN SESSION OF OUR COUNCIL. 81 00:03:41,960 --> 00:03:44,640 AS ALWAYS, I WILL GO THROUGH A 82 00:03:44,640 --> 00:03:46,240 VERY BRIEF SET OF HIGHLIGHTS 83 00:03:46,240 --> 00:03:48,240 OF WHAT IS HAPPENING BUT ALSO 84 00:03:48,240 --> 00:03:50,920 GIVE YOU THE OPPORTUNITY TO 85 00:03:50,920 --> 00:03:52,320 ASK ANY QUESTIONS YOU HAVE GOT 86 00:03:52,320 --> 00:03:53,840 BEFORE WE TURN TO THE REST OF 87 00:03:53,840 --> 00:03:55,120 OUR AGENDA. 88 00:03:55,120 --> 00:03:56,880 NEXT SLIDE, PLEASE. 89 00:03:56,880 --> 00:04:00,560 EACH YEAR UPDATE ON BUDGET AND 90 00:04:00,560 --> 00:04:01,920 SPENDING FOR COUNCIL, NEXT. 91 00:04:01,920 --> 00:04:03,320 WHAT IS NEW THIS YEAR SINCE 92 00:04:03,320 --> 00:04:05,880 OUR LAST SESSION WHEN WE HAD 93 00:04:05,880 --> 00:04:06,920 OUR BUDGET APPROPRIATIONS IS 94 00:04:06,920 --> 00:04:08,840 THE REVISION AND SETTING OF 95 00:04:08,840 --> 00:04:10,960 OUR PAY LINES AS YOU CAN SEE 96 00:04:10,960 --> 00:04:12,240 HERE. 97 00:04:12,240 --> 00:04:14,520 IN THE CSR REVIEWED 98 00:04:14,520 --> 00:04:16,480 APPLICATIONS, THOSE OF A 99 00:04:16,480 --> 00:04:17,640 PERCENTILE THEREFORE, THE 100 00:04:17,640 --> 00:04:21,680 GENERAL PAYLINE FOR THE MOST 101 00:04:21,680 --> 00:04:23,480 COMMON APPLICATIONS UNDER 102 00:04:23,480 --> 00:04:25,760 $500,000 DIRECT COST, THE 103 00:04:25,760 --> 00:04:27,320 15 PERCENT PERTILE IS AT 104 00:04:27,320 --> 00:04:30,120 THRESHOLD AND THIS IS 105 00:04:30,120 --> 00:04:31,840 RELATIVELY GOOD FOR PAST 106 00:04:31,840 --> 00:04:33,680 YEARS, HOPEFULLY WE CAN EVEN 107 00:04:33,680 --> 00:04:34,320 DO BETTER. 108 00:04:34,320 --> 00:04:36,280 THESE ARE NOT FINAL BECAUSE WE 109 00:04:36,280 --> 00:04:38,600 HAVE MORE TIME IN THE YEAR TO 110 00:04:38,600 --> 00:04:40,560 SEE HOW THINGS EVOLVE AND MAKE 111 00:04:40,560 --> 00:04:43,080 REF OCCASIONS TO FUNDING 112 00:04:43,080 --> 00:04:43,800 LEVELS. 113 00:04:43,800 --> 00:04:46,920 WE REMAIN COMMITTED TO NEW 114 00:04:46,920 --> 00:04:48,600 INVESTIGATORS IN AI AND NI, 115 00:04:48,600 --> 00:04:51,000 YOU CAN SEE THERE THE 20TH 116 00:04:51,000 --> 00:04:54,440 PERCENTILE FROM THE GENERAL 117 00:04:54,440 --> 00:04:56,400 PAYLINE, MORE EXPENSIVE AT 118 00:04:56,400 --> 00:04:59,000 $500,000, ALWAYS A PAINFUL 119 00:04:59,000 --> 00:05:00,320 DISCRIMINATION BUT ONE WE IN 120 00:05:00,320 --> 00:05:02,720 LIST TO IN ORDER TO PROTECT 121 00:05:02,720 --> 00:05:04,440 OUR OVERALL PAYLINE, A HIGHER 122 00:05:04,440 --> 00:05:07,840 BAR FOR THOSE APPLICATIONS AT 123 00:05:07,840 --> 00:05:09,000 12TH PERCENTILE BUT THOSE ARE 124 00:05:09,000 --> 00:05:10,760 FOR NEW AND EARLY STAGES 125 00:05:10,760 --> 00:05:11,600 INVESTIGATOR. 126 00:05:11,600 --> 00:05:13,200 AND EACH YEAR, IN FACT SEVERAL 127 00:05:13,200 --> 00:05:16,400 PAST YEARS, WE HAVE HAD A PA 128 00:05:16,400 --> 00:05:19,160 HIGHER PAYLINE IN ALZHEIMER'S 129 00:05:19,160 --> 00:05:21,240 AND DEMENTIA RESEARCH DUE TO 130 00:05:21,240 --> 00:05:22,040 APPROPRIATIONS FROM CONGRESS. 131 00:05:22,040 --> 00:05:24,600 THIS YEAR WE'RE AT THE 25TH 132 00:05:24,600 --> 00:05:30,040 PERCENTILE FOR THE FALL 133 00:05:30,040 --> 00:05:32,800 APPLICATIONS EXCEPT THE NA -- 134 00:05:32,800 --> 00:05:33,320 [INDISCERNIBLE] 135 00:05:33,320 --> 00:05:34,760 -- IN 20TH PERCENTILE. 136 00:05:34,760 --> 00:05:35,840 NEXT, PLEASE. 137 00:05:35,840 --> 00:05:39,320 FOR THE NIA REVIEWED 138 00:05:39,320 --> 00:05:41,280 APPLICATIONS YOU CAN SEE HERE 139 00:05:41,280 --> 00:05:44,560 ONCE AGAIN PROGRAM PROJECTS 140 00:05:44,560 --> 00:05:46,400 AND OTHER RESEARCH, 24TH 141 00:05:46,400 --> 00:05:48,560 PRIORITY SCORE, CAREER 142 00:05:48,560 --> 00:05:49,600 DEVELOPMENT, 24, DEVELOPMENT 143 00:05:49,600 --> 00:05:52,240 IS 30 AGAIN WITH HIGHER PAY 144 00:05:52,240 --> 00:05:55,920 LINES FOR EACH OF THESE AS 145 00:05:55,920 --> 00:06:00,120 ALLOWED WITH THE FUNDING 146 00:06:00,120 --> 00:06:00,480 AVAILABLE. 147 00:06:00,480 --> 00:06:02,680 AS PART OF OUR COMMITMENT TO 148 00:06:02,680 --> 00:06:05,760 USING APPROPRIATED FUNDS THAT 149 00:06:05,760 --> 00:06:07,240 ARE ADARL TARGETED, WE ARE 150 00:06:07,240 --> 00:06:09,880 REGARDED AS OUR OBLIGATION AND 151 00:06:09,880 --> 00:06:14,640 STRATEGY FOR BEST UTILIZING 152 00:06:14,640 --> 00:06:17,160 OUR FUNDED GOALS ACROSS ALL OF 153 00:06:17,160 --> 00:06:18,960 NIH, YOU CAN SEE HERE YEAR 154 00:06:18,960 --> 00:06:20,200 AFTER YEAR THE AMOUNTS THAT 155 00:06:20,200 --> 00:06:23,720 HAVE BEEN GIVEN FROM NIA 156 00:06:23,720 --> 00:06:24,800 APPROPRIATED FUNDS TO SUPPORT 157 00:06:24,800 --> 00:06:27,200 RESEARCH AND YOU CAN SEE FY22, 158 00:06:27,200 --> 00:06:30,480 THE LAST YEAR FOR WHICH WE 159 00:06:30,480 --> 00:06:32,800 HAVE ANY FREE DATA, THIS 160 00:06:32,800 --> 00:06:34,760 WAS -- FOR THE TOTAL YEAR, 161 00:06:34,760 --> 00:06:38,680 NEARLY ALL OF THE SISTER 162 00:06:38,680 --> 00:06:42,320 INSTITUTIONS, NIDS, THE 163 00:06:42,320 --> 00:06:43,600 PRIMARY PARTNERS YOU CAN SEE 164 00:06:43,600 --> 00:06:46,640 ACROSS EACH OF THESE 165 00:06:46,640 --> 00:06:47,760 INSTITUTES, SUBSTANTIAL 166 00:06:47,760 --> 00:06:48,120 FUNDING. 167 00:06:48,120 --> 00:06:49,800 ONE DIMENSION USED THROUGH 168 00:06:49,800 --> 00:06:52,440 FUNDING SUPPLEMENTS THAT ARE 169 00:06:52,440 --> 00:06:53,960 ADRD RELEVANT THROUGH 170 00:06:53,960 --> 00:06:54,840 APPLICATIONS FOR THEMSELVES 171 00:06:54,840 --> 00:06:57,000 AND DID NOT ORIGINATE WITH THE 172 00:06:57,000 --> 00:06:57,640 PRIMARY APPLICATION AND I 173 00:06:57,640 --> 00:07:00,960 THINK THAT HAS BEEN SUCCESSFUL 174 00:07:00,960 --> 00:07:02,680 IN RECRUITING NEW TALENT IN 175 00:07:02,680 --> 00:07:04,800 RESEARCH AND AS WE LOOK AT 176 00:07:04,800 --> 00:07:06,840 THAT PROGRAM, WE SEE A 177 00:07:06,840 --> 00:07:08,280 SUBSTANTIAL NUMBER OF 178 00:07:08,280 --> 00:07:11,160 INDIVIDUALS TURNING TO SUPPORT 179 00:07:11,160 --> 00:07:12,800 ALZ-'S RESEARCH AS A PRIMARY 180 00:07:12,800 --> 00:07:15,000 IN THAT AREA SO IT HAS BEEN 181 00:07:15,000 --> 00:07:16,920 VERY SUCCESSFUL FOR THOSE 182 00:07:16,920 --> 00:07:17,520 PEOPLE. 183 00:07:17,520 --> 00:07:18,040 NEXT PLEASE. 184 00:07:18,040 --> 00:07:20,200 THE SAME LINE, WE HAVE LOOKED 185 00:07:20,200 --> 00:07:21,720 AT WHERE OUR RESEARCH 186 00:07:21,720 --> 00:07:22,520 APPLICATIONS AND FUNDING ARE 187 00:07:22,520 --> 00:07:25,640 GOING AND OVER THE YEARS FROM 188 00:07:25,640 --> 00:07:29,560 2015 TO 2022, THE YEARS HAVE 189 00:07:29,560 --> 00:07:30,400 INCREASED TARGETED FUNNELING 190 00:07:30,400 --> 00:07:32,680 BY ABOUT A THIRD FOR NEW AND 191 00:07:32,680 --> 00:07:34,160 EARLY STAGE INVESTIGATORS AND 192 00:07:34,160 --> 00:07:37,000 THIS IS A IMPORTANT STRATEGY 193 00:07:37,000 --> 00:07:39,440 FOR SIMPLY NOT INCREASING 194 00:07:39,440 --> 00:07:43,040 FUNDING FOR VERY ABLE AND 195 00:07:43,040 --> 00:07:43,640 ESTABLISHED RESEARCHERS 196 00:07:43,640 --> 00:07:44,440 BROUGHT TO THE FIELD AND WILL 197 00:07:44,440 --> 00:07:46,760 NOW WE HAVE A NEW CATEGORY 198 00:07:46,760 --> 00:07:49,440 CALLED NEW TO THE FILED AND 199 00:07:49,440 --> 00:07:51,520 THOSE ARE INVESTIGATORS WHO 200 00:07:51,520 --> 00:07:55,160 NEVER HAVE APPLIED FOR 201 00:07:55,160 --> 00:07:57,560 RESEARCH AT NIH AND A FIFTH 202 00:07:57,560 --> 00:08:00,160 WHO HAVE NEVER APPLIED FOR SO 203 00:08:00,160 --> 00:08:04,200 THIS CONTINUES TO BE A HEALTHY 204 00:08:04,200 --> 00:08:07,040 WAY FOR RECRUITING FOR THE 205 00:08:07,040 --> 00:08:10,120 MOST DIVERSE AND AGING 206 00:08:10,120 --> 00:08:10,680 POPULATIONS. 207 00:08:10,680 --> 00:08:12,400 NEXT, YOU HAVE HEARD A LITTLE 208 00:08:12,400 --> 00:08:14,400 BIT ABOUT THE REAL WORLD DATA 209 00:08:14,400 --> 00:08:14,800 INITIATIVE. 210 00:08:14,800 --> 00:08:18,720 YOU CAN SEE HERE IT IS A VERY 211 00:08:18,720 --> 00:08:19,560 SUBSTANTIAL AND AMBITIOUS 212 00:08:19,560 --> 00:08:20,840 ENTERPRISE DESIGNED TO LOOK AT 213 00:08:20,840 --> 00:08:25,400 REAL WORLD DATA OF MULTIPLE 214 00:08:25,400 --> 00:08:28,560 ORIGINS, TO LOOK AT THE 215 00:08:28,560 --> 00:08:30,160 PHYSICAL SIFT AND 216 00:08:30,160 --> 00:08:31,360 HARMONIZATION FOR A MULTITUDE 217 00:08:31,360 --> 00:08:33,800 OF PURPOSES BUT YOU CAN SEE ON 218 00:08:33,800 --> 00:08:36,160 THE LEFT THE KIND OF DATA WE 219 00:08:36,160 --> 00:08:39,400 HAVE IN MIND, HEALTH RECORDS, 220 00:08:39,400 --> 00:08:41,080 PHARMACY CHANGE, EVENTUALLY 221 00:08:41,080 --> 00:08:43,160 MONITORING OF SOCIAL 222 00:08:43,160 --> 00:08:45,280 DETERMINANTS OF HEALTH, 223 00:08:45,280 --> 00:08:48,040 SENSORS, ALL TO COMPILE AN 224 00:08:48,040 --> 00:08:50,200 INTEGRATED DATABASE WHICH IS 225 00:08:50,200 --> 00:08:52,520 TARGETED TO FUND 80 PERCENT 226 00:08:52,520 --> 00:08:54,480 COVERAGE WITHIN NARD AND THE 227 00:08:54,480 --> 00:08:55,720 AVERAGE POPULATION. 228 00:08:55,720 --> 00:08:58,840 THE PURPOSES NOTED, SCREENING, 229 00:08:58,840 --> 00:09:01,720 RECRUITMENT, AS A MEANS OF 230 00:09:01,720 --> 00:09:05,040 RECRUITING PEOPLE INTO 231 00:09:05,040 --> 00:09:06,320 STUDIES, TRIALS, REPURPOSING, 232 00:09:06,320 --> 00:09:08,760 LOOKING AT PEOPLE AT AN 233 00:09:08,760 --> 00:09:12,960 OBSERVATIONAL LEVEL IN TERMS 234 00:09:12,960 --> 00:09:16,160 OF FUNCTION, DEMENTIA 235 00:09:16,160 --> 00:09:19,360 PROGRESSION FOR DRUG EXPOSURES 236 00:09:19,360 --> 00:09:22,040 THAT CAN LEAD TO TRIALS. 237 00:09:22,040 --> 00:09:22,880 LONG-TERM FOLLOW UP FOR 238 00:09:22,880 --> 00:09:24,480 INDIVIDUALS WHO MAY BE UNDER 239 00:09:24,480 --> 00:09:26,320 TREATMENT THAT ORIGINATED IN 240 00:09:26,320 --> 00:09:27,840 CLINICAL TRIALS, HAPPEN TO 241 00:09:27,840 --> 00:09:29,720 SAY -- WE'RE ALL VERY EXCITED 242 00:09:29,720 --> 00:09:32,560 ABOUT THE FACT WE'RE NOW 243 00:09:32,560 --> 00:09:34,080 SEEING ALZHEIMER'S TREATMENTS 244 00:09:34,080 --> 00:09:35,160 WHICH ARE REFLECTING OUTCOMES 245 00:09:35,160 --> 00:09:36,520 AND NOT YET TO THE POINT WE 246 00:09:36,520 --> 00:09:38,560 WOULD LIKE THEM TO BE BUT 247 00:09:38,560 --> 00:09:40,000 CERTAINLY PROMISING. 248 00:09:40,000 --> 00:09:43,160 NOW IT IS CRITICAL FOR THE 249 00:09:43,160 --> 00:09:45,880 PRESENT IN ALL THESE STUDIES 250 00:09:45,880 --> 00:09:47,400 TO PUT CLINICAL TRIALS INTO 251 00:09:47,400 --> 00:09:49,000 COMMON AND GENERAL USE. 252 00:09:49,000 --> 00:09:50,200 WE FEEL REAL OBLIGATION TO 253 00:09:50,200 --> 00:09:52,240 TRACK HOW THEY ARE PERFORMING 254 00:09:52,240 --> 00:09:55,480 IN DIVERSE POPULATIONS THAT 255 00:09:55,480 --> 00:09:57,040 CAN'T BE INCORPORATED ACTIVELY 256 00:09:57,040 --> 00:10:00,360 BECAUSE IT IS A TRIAL AND AS 257 00:10:00,360 --> 00:10:03,400 WELL AS ANY OTHER TRIAL THAT 258 00:10:03,400 --> 00:10:05,600 MIGHT BE CONDUCTED WITH THESE 259 00:10:05,600 --> 00:10:06,120 TRIALS. 260 00:10:06,120 --> 00:10:07,600 TO APPLICATIONS BY JULY, THEN 261 00:10:07,600 --> 00:10:13,320 PEER REVIEW AND IF THERE ARE 262 00:10:13,320 --> 00:10:13,920 SUFFICIENT MERITORIOUS 263 00:10:13,920 --> 00:10:15,600 APPLICATIONS TO FUND ONE, WE 264 00:10:15,600 --> 00:10:18,040 WILL FUND IT IN FY24. 265 00:10:18,040 --> 00:10:19,800 THE VIEW HERE WILL BE 266 00:10:19,800 --> 00:10:20,840 PARTICULARLY CHALLENGING, THE 267 00:10:20,840 --> 00:10:24,960 DEMAND IN TERMS OF CLINICAL 268 00:10:24,960 --> 00:10:27,800 DATA MANAGEMENT, ETHICS, ALL 269 00:10:27,800 --> 00:10:30,760 OF THESE INCORPORATED INTO A 270 00:10:30,760 --> 00:10:32,840 PEER REVIEW WHO ARE NOT IN 271 00:10:32,840 --> 00:10:35,320 CONFLICT WITH THE APPLICATION 272 00:10:35,320 --> 00:10:39,560 AND THOSE LIKELY TO BE A VERY 273 00:10:39,560 --> 00:10:41,840 LARGE CONSORTIA NOT DEPICTED 274 00:10:41,840 --> 00:10:42,160 BEFORE. 275 00:10:42,160 --> 00:10:43,640 AND TO ILLUSTRATE SOME OF 276 00:10:43,640 --> 00:10:45,920 THOSE POINTS I MENTIONED IN 277 00:10:45,920 --> 00:10:47,120 VOTED FORM. 278 00:10:47,120 --> 00:10:47,400 NEXT. 279 00:10:47,400 --> 00:10:50,680 A BIT OF A STRUCTURE, COMPLEX 280 00:10:50,680 --> 00:10:52,200 COOPERATIVE AGREEMENT WHICH 281 00:10:52,200 --> 00:10:53,360 MEANS NIA STAFF WILL BE 282 00:10:53,360 --> 00:10:55,360 PLAYING AN IMPORTANT ROLE IN 283 00:10:55,360 --> 00:11:01,880 WORKING WITH THE AWARDEE. 284 00:11:01,880 --> 00:11:06,240 THERE ARE CONVENTIONAL 285 00:11:06,240 --> 00:11:08,840 ADMINISTRATIVE CORES HERE BUT 286 00:11:08,840 --> 00:11:12,120 YOU WILL NOTICE INCUBATIVE 287 00:11:12,120 --> 00:11:14,440 TRIALS TO LOOK AT FEASIBILITY. 288 00:11:14,440 --> 00:11:16,960 STAKEHOLDER PRIVACY AND ETHICS 289 00:11:16,960 --> 00:11:21,040 CORE, WE MENTIONED IS AN 290 00:11:21,040 --> 00:11:23,600 IMPORTANT ONE AND UNIQUELY 291 00:11:23,600 --> 00:11:25,120 EMPHASIZE THE RNA THAT WENT 292 00:11:25,120 --> 00:11:27,040 OUT AND INTEND TO FOLLOW UP IS 293 00:11:27,040 --> 00:11:28,440 THE USE OF MILESTONES AND 294 00:11:28,440 --> 00:11:29,640 STRICT ATTENTION TO THEM. 295 00:11:29,640 --> 00:11:32,400 AND WE HAVE BEEN CAREFUL TO 296 00:11:32,400 --> 00:11:33,800 OUR WORKING WITH NIH 297 00:11:33,800 --> 00:11:34,800 AUTHORITIES TO MAKE SURE THAT 298 00:11:34,800 --> 00:11:38,640 WE HAD IN THE RSA AND 299 00:11:38,640 --> 00:11:39,720 THEREFORE IN TERMS AND 300 00:11:39,720 --> 00:11:41,520 CONDITIONS OUR ABILITY TO 301 00:11:41,520 --> 00:11:44,320 MONITOR IN THE FIRST MONTH HOW 302 00:11:44,320 --> 00:11:45,960 PERFORMANCE IS OCCURRING AND 303 00:11:45,960 --> 00:11:51,400 MAKE CHANGES TO ALTER THE ASK 304 00:11:51,400 --> 00:11:54,040 SCIENCE, TO TERMINATE WORST 305 00:11:54,040 --> 00:11:55,000 KATE FAILURES DECLARED, WHAT 306 00:11:55,000 --> 00:11:58,840 WE HOPE TO MOST AVOID BUT BY 307 00:11:58,840 --> 00:12:00,960 HAVING CLOSE SUPERVISION AND 308 00:12:00,960 --> 00:12:02,440 ADVISORY GROUPS, LOOKING AT 309 00:12:02,440 --> 00:12:05,080 THIS AS IT EVOLVES AND ONE 310 00:12:05,080 --> 00:12:07,080 WHICH IS A VERY EXCITING 311 00:12:07,080 --> 00:12:08,920 POTENTIAL BUT ONE WE DON'T 312 00:12:08,920 --> 00:12:09,800 TAKE LIGHTLY. 313 00:12:09,800 --> 00:12:10,320 NEXT, PLEASE. 314 00:12:10,320 --> 00:12:14,200 YOU HEARD A LITTLE ABOUT THIS 315 00:12:14,200 --> 00:12:17,200 ONE YESTERDAY, THE NIA HEALTHY 316 00:12:17,200 --> 00:12:19,600 AGING STARTUP CHALLENGE AND IT 317 00:12:19,600 --> 00:12:21,400 REVOLVES AROUND OUR SMALL 318 00:12:21,400 --> 00:12:23,120 BUSINESS ENTERPRISE AND 319 00:12:23,120 --> 00:12:25,400 REALIZATION THAT ONLY SMALL 320 00:12:25,400 --> 00:12:29,080 FRACTIONS OF THOSE WHO RECEIVE 321 00:12:29,080 --> 00:12:31,960 PH.D., MD DOCTORAL DEGREES IN 322 00:12:31,960 --> 00:12:34,120 BEHAVIORAL OF SOCIAL AND 323 00:12:34,120 --> 00:12:35,960 BIOLOGICAL SCIENCES END UP IN 324 00:12:35,960 --> 00:12:39,400 CLASSIC, IF YOU WILL, ACADEMIC 325 00:12:39,400 --> 00:12:40,680 CAREERS SO TO PREPARE FOR 326 00:12:40,680 --> 00:12:42,400 INDIVIDUALS WHO MIGHT CHOOSE 327 00:12:42,400 --> 00:12:44,960 TO MOVE INTO MORE 328 00:12:44,960 --> 00:12:47,960 ENTREPRENEURIAL AREAS AND TO 329 00:12:47,960 --> 00:12:49,760 IMPORTANTLY REINFORCE THE 330 00:12:49,760 --> 00:12:50,640 ENTREPRENEURIAL SEGMENTS WITH 331 00:12:50,640 --> 00:12:52,320 THE KIND OF TALENT THAT IS 332 00:12:52,320 --> 00:12:54,200 NEEDED TO ESTABLISH THIS 333 00:12:54,200 --> 00:12:55,920 PROGRAM WITH APPLICATIONS. 334 00:12:55,920 --> 00:12:58,560 FIRST YEAR FISCAL 22, OVER 200 335 00:12:58,560 --> 00:12:59,600 APPLICATIONS PEOPLE ARE 336 00:12:59,600 --> 00:13:00,120 MAKING. 337 00:13:00,120 --> 00:13:04,240 WE STARTED TO DISCUSS 338 00:13:04,240 --> 00:13:05,400 YESTERDAY THEIR INTENT TO 339 00:13:05,400 --> 00:13:06,880 DEMONSTRATE THE WAY THEY 340 00:13:06,880 --> 00:13:08,280 PROPOSE THE SCIENCE THEY ARE 341 00:13:08,280 --> 00:13:10,480 DOING AND HOW IT IS 342 00:13:10,480 --> 00:13:11,520 COMMERCIALLY TRANSLATABLE. 343 00:13:11,520 --> 00:13:12,240 THEY HAVE LONG-TERM 344 00:13:12,240 --> 00:13:13,080 ESTABLISHED RELATIONSHIPS WITH 345 00:13:13,080 --> 00:13:17,080 MENTORS IN THE FIELD, EXPERTS 346 00:13:17,080 --> 00:13:17,880 IN ENTREPRENEURIAL RESEARCH. 347 00:13:17,880 --> 00:13:19,440 AS A RESULT OF THEIR FIRST 348 00:13:19,440 --> 00:13:20,760 EFFORTS THERE IS A NARROWING 349 00:13:20,760 --> 00:13:23,280 DOWN TO A SET OF FINALISTS. 350 00:13:23,280 --> 00:13:26,560 IN THE PAST YEAR, WE TOOK 351 00:13:26,560 --> 00:13:28,880 THOSE 20 FINALISTS WHO 352 00:13:28,880 --> 00:13:30,160 RECEIVED MORE INTENSIVE BOOT 353 00:13:30,160 --> 00:13:33,800 CAMP TRAINING FOR A FINAL 354 00:13:33,800 --> 00:13:35,800 AWARD OF $50,000 CASH TO BEGIN 355 00:13:35,800 --> 00:13:38,320 THE RESEARCH THAT PUTS THEM ON 356 00:13:38,320 --> 00:13:39,280 THE ROAD TOWARDS 357 00:13:39,280 --> 00:13:39,840 ENTREPRENEURIAL WORK. 358 00:13:39,840 --> 00:13:43,280 YOU CAN SEE THE DIVERSITY 359 00:13:43,280 --> 00:13:47,080 ACHIEVED IN THE AWARDEES HERE 360 00:13:47,080 --> 00:13:49,560 AND THE TOPICS. 361 00:13:49,560 --> 00:13:52,080 SO QUITE GRATIFYING AND CREDIT 362 00:13:52,080 --> 00:13:55,960 TO STAFF AT NIA WHO HELPED PUT 363 00:13:55,960 --> 00:13:58,320 TOGETHER THIS VERY INNOVATIVE 364 00:13:58,320 --> 00:13:59,560 PROGRAM. 365 00:13:59,560 --> 00:14:00,000 NEXT, PLEASE. 366 00:14:00,000 --> 00:14:02,760 LET'S SEE, RESEARCH SUM MITTS 367 00:14:02,760 --> 00:14:06,160 HELD ON AN A BASIS. 368 00:14:06,160 --> 00:14:09,320 THIS YEAR, 2023 MARCH, 369 00:14:09,320 --> 00:14:11,160 INCLUDED THE CARE SERVICE AND 370 00:14:11,160 --> 00:14:12,760 SUPPORT FOR PERSONS LIVING 371 00:14:12,760 --> 00:14:20,720 WITH DEMENTIA AND THEIR CARE 372 00:14:20,720 --> 00:14:23,880 PARTNERS, I HOPE THIS HAS BEEN 373 00:14:23,880 --> 00:14:29,000 ARCHIVED AND THE RECORDING IS 374 00:14:29,000 --> 00:14:32,840 SHOWN HERE THAT OPTIMIZE THE 375 00:14:32,840 --> 00:14:40,480 RESEARCH AND CONTINUED 376 00:14:40,480 --> 00:14:40,960 INNOVATION. 377 00:14:40,960 --> 00:14:44,400 THIS IS THE FOURTH HELD LAST 378 00:14:44,400 --> 00:14:45,800 MONTH IN APRIL, THE INSTANCE 379 00:14:45,800 --> 00:14:48,280 YOU SEE HERE IN EIGHT 380 00:14:48,280 --> 00:14:50,000 BIOLOGICAL SESSIONS, WANT TO 381 00:14:50,000 --> 00:14:51,720 LOOK AT DETERMINANTS OF HEALTH 382 00:14:51,720 --> 00:14:53,600 AND HEALTH DISPARITIES, A NEW 383 00:14:53,600 --> 00:14:58,000 ENTITY FOCUS IN THE 384 00:14:58,000 --> 00:15:06,240 GERI-SCIENCE AREA AS WELL AS 385 00:15:06,240 --> 00:15:08,440 HIGH LOW DYSFUNCTION 386 00:15:08,440 --> 00:15:09,160 MULTIDEFICITS, MEASURING 387 00:15:09,160 --> 00:15:10,280 HEALTH, MODELING OF THE DATA 388 00:15:10,280 --> 00:15:16,040 WE HAVE AROUND HEALTHY, AGING 389 00:15:16,040 --> 00:15:25,240 AND LONGEVITY BIOMARKERS FOR 390 00:15:25,240 --> 00:15:26,480 GERISCIENCE AND THE NATURE OF 391 00:15:26,480 --> 00:15:27,520 THE TRIALS. 392 00:15:27,520 --> 00:15:31,160 SO I HOPE MANY PEOPLE ARE ABLE 393 00:15:31,160 --> 00:15:35,200 TO ATTEND AND THIS HAS NOT 394 00:15:35,200 --> 00:15:37,160 BEEN ARCHIVED YET. 395 00:15:37,160 --> 00:15:37,560 [INAUDIBLE] 396 00:15:37,560 --> 00:15:39,760 >>VERY GOOD. 397 00:15:39,760 --> 00:15:40,760 THANK YOU, NEXT. 398 00:15:40,760 --> 00:15:43,320 WITH OUR CONSTANT EFFORTS TO 399 00:15:43,320 --> 00:15:44,360 DISSEMINATE PROGRESS AS A 400 00:15:44,360 --> 00:15:47,480 RESULT OF THE NIH RESEARCH, AN 401 00:15:47,480 --> 00:15:49,360 EXAMPLE OF PRESS RELEASES AND 402 00:15:49,360 --> 00:15:51,560 HIGHLIGHTS IN A WAY WE WORK 403 00:15:51,560 --> 00:15:53,760 WITH STAKEHOLDERS AS WELL AS 404 00:15:53,760 --> 00:15:55,360 PARTICIPATING IN CONGRESSIONAL 405 00:15:55,360 --> 00:15:56,680 BRIEFINGS AND HEARINGS. 406 00:15:56,680 --> 00:15:58,440 NEXT, PLEASE. 407 00:15:58,440 --> 00:16:02,280 OKAY, NEXT, SOME UPDATES. 408 00:16:02,280 --> 00:16:04,080 AMONG THE COMMON FUND 409 00:16:04,080 --> 00:16:06,680 INITIATIVES THAT HAVE BEEN OF 410 00:16:06,680 --> 00:16:09,080 GREATEST RELEVANCE TO OUR NIA 411 00:16:09,080 --> 00:16:13,040 MISSION THAT MANY HAVE IS THE 412 00:16:13,040 --> 00:16:14,560 CELLULAR SIN SYNAPTIC NETWORK. 413 00:16:14,560 --> 00:16:18,560 MANY OF YOU MAY BE AWARE THE 414 00:16:18,560 --> 00:16:19,600 COMMON FUND WITHIN THE OFFICE 415 00:16:19,600 --> 00:16:22,600 OF THE DIRECTOR OF NIH AND 416 00:16:22,600 --> 00:16:24,200 AMONG ITS ACTIVITIES LOOKS 417 00:16:24,200 --> 00:16:25,680 EACH YEAR AT INITIATIVES THAT 418 00:16:25,680 --> 00:16:29,320 ARE OF HIGH IMPORTANT AND THAT 419 00:16:29,320 --> 00:16:30,480 SPAN THE INTEREST OF MOST OF 420 00:16:30,480 --> 00:16:32,000 OF THE CENTERS AND ONE OF 421 00:16:32,000 --> 00:16:34,280 THESE IS THE CELLULAR NETWORK 422 00:16:34,280 --> 00:16:36,840 THAT BEGAN AND CONTINUES WITH 423 00:16:36,840 --> 00:16:40,200 PRIMARY LEADERSHIP FROM NIA 424 00:16:40,200 --> 00:16:41,200 AND NCI. 425 00:16:41,200 --> 00:16:44,800 WE'RE AT THE STAGE NOW WHERE 426 00:16:44,800 --> 00:16:50,560 WE ARE BEGINNING TO SEE SOME 427 00:16:50,560 --> 00:16:52,160 CONCRETE PROGRESS IN RESEARCH, 428 00:16:52,160 --> 00:16:53,840 A MEETING OF INVESTIGATORS 429 00:16:53,840 --> 00:16:56,480 GENERALLY THIS YEAR WAS REALLY 430 00:16:56,480 --> 00:16:57,560 A VERY EXCITING OPPORTUNITY. 431 00:16:57,560 --> 00:16:59,640 SOME OF YOU WERE THERE. 432 00:16:59,640 --> 00:17:03,520 AND THIS WILL PROVIDE I THINK 433 00:17:03,520 --> 00:17:04,800 A SYSTEMIC INFRASTRUCTURE THAT 434 00:17:04,800 --> 00:17:07,360 WILL THEN TAKE OFF THROUGH THE 435 00:17:07,360 --> 00:17:07,880 APPLICATIONS. 436 00:17:07,880 --> 00:17:12,440 HUMAN AND MOUTH IN WHICH THE 437 00:17:12,440 --> 00:17:13,920 STIMULATIONS AND A VARIETY OF 438 00:17:13,920 --> 00:17:15,720 SYSTEMS HAPPEN THAT WILL BE 439 00:17:15,720 --> 00:17:17,240 THE BASELINE OF DATA FOR A 440 00:17:17,240 --> 00:17:24,160 GREAT DEAL OF RESEARCH TO 441 00:17:24,160 --> 00:17:24,440 COME. 442 00:17:24,440 --> 00:17:26,600 NEXT SLIDE. 443 00:17:26,600 --> 00:17:30,200 THE COUNCIL WITH 444 00:17:30,200 --> 00:17:33,760 INFRASTRUCTURE RACISM, 445 00:17:33,760 --> 00:17:34,400 PARTICULARLY THROUGH RUBIN 446 00:17:34,400 --> 00:17:36,520 KNIGHT WHAT HAS BEEN A VERY 447 00:17:36,520 --> 00:17:38,040 ACTIVE LEADER IN THIS AREA AND 448 00:17:38,040 --> 00:17:40,560 I STRESS AGAIN THE NIH 449 00:17:40,560 --> 00:17:41,840 COMMITMENT TO IT, YOU CAN SEE 450 00:17:41,840 --> 00:17:46,720 SOME OF THE PEOPLE INVOLVED IN 451 00:17:46,720 --> 00:17:49,240 LEADERSHIP THERE, FRANK, 452 00:17:49,240 --> 00:17:49,720 PATRICIA. 453 00:17:49,720 --> 00:17:51,880 AND IN ADDITION TO OUR 454 00:17:51,880 --> 00:17:53,200 COMMITMENT INCIDENT TAOUPBLGS 455 00:17:53,200 --> 00:17:58,080 ALLY TO THESE PRINCIPLES, OUR 456 00:17:58,080 --> 00:17:59,000 PREVIOUS DIRECTOR MARIE 457 00:17:59,000 --> 00:17:59,920 BERNARD IS PLAYING A ROLE AND 458 00:17:59,920 --> 00:18:01,720 WILL IT IS WITH GREAT 459 00:18:01,720 --> 00:18:03,760 EXCITEMENT WE WERE ABLE TO 460 00:18:03,760 --> 00:18:05,680 RECRUIT AMY KELLY FOR MULTIPLE 461 00:18:05,680 --> 00:18:08,760 REASONS BUT AMONG OTHERS, FOR 462 00:18:08,760 --> 00:18:11,840 HER ROLE AND RESPONSIBILITIES 463 00:18:11,840 --> 00:18:14,080 IN LEADING NIA EFFORTS IN THIS 464 00:18:14,080 --> 00:18:14,400 AREA. 465 00:18:14,400 --> 00:18:18,240 NEXT, PLEASE. 466 00:18:18,240 --> 00:18:20,520 THE INAUGURAL REPORT IS GOING 467 00:18:20,520 --> 00:18:26,280 TO BE DESCRIBED AS A SELECTIVE 468 00:18:26,280 --> 00:18:27,520 ACHIEVEMENT IN 21-22, THE 469 00:18:27,520 --> 00:18:29,240 YEARS IT HAS BEEN IN EXISTENCE 470 00:18:29,240 --> 00:18:30,920 AND HERE IS A LINK ON THE 471 00:18:30,920 --> 00:18:31,960 SLIDE AS WELL. 472 00:18:31,960 --> 00:18:35,720 NEXT SLIDE. 473 00:18:35,720 --> 00:18:37,640 NIH STRATEGY AND PLAN 474 00:18:37,640 --> 00:18:39,960 PUBLISHED AND THIS IS A 475 00:18:39,960 --> 00:18:42,160 SIGNIFICANT PLAN FROM YEARS 476 00:18:42,160 --> 00:18:42,440 23-27. 477 00:18:42,440 --> 00:18:44,920 NEXT, AND WE WILL TURN NOW TO 478 00:18:44,920 --> 00:18:47,240 A DELIGHTFUL ASPECT OF WHAT WE 479 00:18:47,240 --> 00:18:49,720 DO FOR NIH STAFF, UPDATES IN 480 00:18:49,720 --> 00:18:52,040 TERMS OF NEW RECRUITMENT, 481 00:18:52,040 --> 00:18:53,560 THERE HAVE BEEN A GREAT NUMBER 482 00:18:53,560 --> 00:18:55,400 AND I JUST TO WANT SHARE THE 483 00:18:55,400 --> 00:18:57,360 INFORMATION YOU ARE SEEING AT 484 00:18:57,360 --> 00:19:00,320 THE NIH LEVEL IN TERMS OF WHAT 485 00:19:00,320 --> 00:19:02,960 IS NEW AND THE PRESIDENT WILL 486 00:19:02,960 --> 00:19:05,480 BE NOMINATING MONICA FOR THE 487 00:19:05,480 --> 00:19:06,080 NIH DIRECTOR POSITION. 488 00:19:06,080 --> 00:19:09,720 SHE HAS BEEN THE NCI DIRECTOR 489 00:19:09,720 --> 00:19:11,560 SINCE OCTOBER, THE FIRST 490 00:19:11,560 --> 00:19:13,160 WOMAN, FEMALE DIRECTOR OF NCI 491 00:19:13,160 --> 00:19:15,640 WOULD IF BE THE SECOND NIH 492 00:19:15,640 --> 00:19:16,080 DIRECTOR. 493 00:19:16,080 --> 00:19:18,440 JUST TO REMIND YOU THE NIH 494 00:19:18,440 --> 00:19:20,480 DIRECTOR POSITION IN ADDITION 495 00:19:20,480 --> 00:19:22,440 TO DIRECTIONS, NOMINATIONS BY 496 00:19:22,440 --> 00:19:23,800 THE PRESIDENT REQUIRES SENATE 497 00:19:23,800 --> 00:19:26,840 APPROVAL FOR THIS PROCESS TO 498 00:19:26,840 --> 00:19:28,560 CONTINUE WE HOPE WITHOUT DELAY 499 00:19:28,560 --> 00:19:33,160 AND LOOK FORWARD TO HAVING NIA 500 00:19:33,160 --> 00:19:36,160 LEADERSHIP AS WELL AND 501 00:19:36,160 --> 00:19:37,400 RECRUITING FOR DEPUTY DIRECTOR 502 00:19:37,400 --> 00:19:38,040 AS WELL. 503 00:19:38,040 --> 00:19:39,840 SO LET ME TURN IT OVER TO THE 504 00:19:39,840 --> 00:19:41,400 LEADERSHIP AND ONCE WE'RE 505 00:19:41,400 --> 00:19:45,080 THROUGH HERE, I WILL BE HAPPY 506 00:19:45,080 --> 00:19:46,320 TO UNDERTAKEN ANY QUESTIONS 507 00:19:46,320 --> 00:19:49,520 YOU MAY HAVE ON ANY GENERAL 508 00:19:49,520 --> 00:19:58,320 TOPIC SO WE START WITH THE 509 00:19:58,320 --> 00:20:00,800 NAB. 510 00:20:00,800 --> 00:20:01,880 >>WELCOME. 511 00:20:01,880 --> 00:20:04,320 RON COHINSKI, DIRECTOR OF 512 00:20:04,320 --> 00:20:05,680 INSTITUTIONAL AGING BIOLOGY 513 00:20:05,680 --> 00:20:07,960 AND PLEASURE TO ANNOUNCE THREE 514 00:20:07,960 --> 00:20:11,440 NEW STAFF MEMBERS SHOWN HERE 515 00:20:11,440 --> 00:20:15,280 WHO COME TO US THROUGH NIAA 516 00:20:15,280 --> 00:20:24,280 AND ANDRES HAS THE PORTFOLIO 517 00:20:24,280 --> 00:20:28,040 APPROACHING HOMEOSTASIS AND 518 00:20:28,040 --> 00:20:31,320 CALLED THE PORTFOLIO OF 519 00:20:31,320 --> 00:20:33,440 RANGING ACTIVITY ON CELLULAR 520 00:20:33,440 --> 00:20:35,120 NETWORK BEFORE HE JOINED THE 521 00:20:35,120 --> 00:20:37,320 NATIONAL INUSE IT ON AGING AND 522 00:20:37,320 --> 00:20:39,400 JUST AS BACKGROUND, PROTEIN 523 00:20:39,400 --> 00:20:41,280 BIOLOGY WOULD BE THE SIMPLEST 524 00:20:41,280 --> 00:20:44,720 WAY TO PUT IT. 525 00:20:44,720 --> 00:20:46,800 AND Dr. SARANG IS JOINING US 526 00:20:46,800 --> 00:20:50,120 FROM SEVERAL INSTITUTES ACROSS 527 00:20:50,120 --> 00:20:56,640 HERE CAREER, II GM S, NIAMS, 528 00:20:56,640 --> 00:20:58,680 NHLBI, HER FIRST EXPERIENCE 529 00:20:58,680 --> 00:21:01,760 ACROSS NIH HAS ALREADY PROVEN 530 00:21:01,760 --> 00:21:05,760 INVALUABLE TO AGING BIOLOGY 531 00:21:05,760 --> 00:21:07,080 AND NIA INVOLVED. 532 00:21:07,080 --> 00:21:08,520 NEXT SLIDE, PLEASE. 533 00:21:08,520 --> 00:21:11,040 PROGRAM DIRECTOR FOR HIV AND 534 00:21:11,040 --> 00:21:14,760 AGING RESEARCH, THIS IS A 535 00:21:14,760 --> 00:21:15,480 TRANSNIA POSITION HOUSED IN 536 00:21:15,480 --> 00:21:19,480 THE DIVISION OF AGING BIOLOGY. 537 00:21:19,480 --> 00:21:21,240 AND SHE HAS A LONG HISTORY OF 538 00:21:21,240 --> 00:21:26,360 WORKING IN THE AREAS OF HIV 539 00:21:26,360 --> 00:21:26,720 RESEARCH. 540 00:21:26,720 --> 00:21:30,160 WELCOME TO ALL THREE NEW STAFF 541 00:21:30,160 --> 00:21:30,480 MEMBERS. 542 00:21:30,480 --> 00:21:31,880 THANK YOU. 543 00:21:31,880 --> 00:21:32,680 >>NEXT SLIDE, PLEASE. 544 00:21:32,680 --> 00:21:35,280 HI, I AM -- 545 00:21:35,280 --> 00:21:36,280 [INDISCERNIBLE] 546 00:21:36,280 --> 00:21:39,120 AND I WOULD LIKE TO EXTEND A 547 00:21:39,120 --> 00:21:44,920 WELCOME TO OUR NEW STAFF. 548 00:21:44,920 --> 00:21:48,560 FIRST, A VANA JOINS AS A 549 00:21:48,560 --> 00:21:52,560 PROGRAM ANALYST -- [INAUDIBLE] 550 00:21:52,560 --> 00:22:00,240 SHE JOINS US FROM THE NIH 551 00:22:00,240 --> 00:22:06,280 PLATFORM WITH A DEGREE -- 552 00:22:06,280 --> 00:22:07,960 [INDISCERNIBLE] 553 00:22:07,960 --> 00:22:11,600 NEXT UP, Dr. HOOKER JOINING 554 00:22:11,600 --> 00:22:13,720 AS A PROGRAM OFFICER TO 555 00:22:13,720 --> 00:22:15,160 OVERSEE OUR PORTFOLIO ON 556 00:22:15,160 --> 00:22:17,240 SPECIAL BIOLOGY AND -- 557 00:22:17,240 --> 00:22:17,880 [INDISCERNIBLE] 558 00:22:17,880 --> 00:22:20,760 SHE JOINS US UNC CHAPEL HILL 559 00:22:20,760 --> 00:22:24,640 WHERE SHE COMPLETED HER 560 00:22:24,640 --> 00:22:25,560 POST-DOC TRAINING IN 561 00:22:25,560 --> 00:22:26,840 PSYCHOLOGY AND SOCIAL 562 00:22:26,840 --> 00:22:27,440 BEHAVIOR. 563 00:22:27,440 --> 00:22:28,200 NEXT SLIDE, PLEASE. 564 00:22:28,200 --> 00:22:32,720 AND NEXT I WOULD INTRODUCE 565 00:22:32,720 --> 00:22:33,440 Dr -- 566 00:22:33,440 --> 00:22:33,880 [INDISCERNIBLE] 567 00:22:33,880 --> 00:22:34,800 , THANK YOU. 568 00:22:34,800 --> 00:22:38,000 JOINS US AS DEPUTY DIRECTOR OF 569 00:22:38,000 --> 00:22:39,640 THE OFFICE OF DATA RESOURCES 570 00:22:39,640 --> 00:22:42,760 AND SO FAR COORDINATING A 571 00:22:42,760 --> 00:22:45,400 VARIETY OF DATA RELATED TO 572 00:22:45,400 --> 00:22:46,720 RESOURCES. 573 00:22:46,720 --> 00:22:50,120 HAS A DOCTORATE IN HEALTH 574 00:22:50,120 --> 00:22:52,960 SCIENCES AND A MASTER IN 575 00:22:52,960 --> 00:22:57,080 HEALTH SCIENCES -- 576 00:22:57,080 --> 00:22:57,560 [INDISCERNIBLE] 577 00:22:57,560 --> 00:23:04,520 AND ALSO WITH US IN THE ROOM, 578 00:23:04,520 --> 00:23:06,880 EVERYONE SAY HI TO COSIA, 579 00:23:06,880 --> 00:23:11,800 JOINS US IN HSR TO MANAGE OUR 580 00:23:11,800 --> 00:23:13,680 FIELD EXPERIMENTING PROCESS 581 00:23:13,680 --> 00:23:15,200 RELATED TO MACRO SOCIAL 582 00:23:15,200 --> 00:23:16,360 FACTORS AND DRIVERS OF SOCIAL 583 00:23:16,360 --> 00:23:22,280 HEALTH THAT ARE THE LIFE 584 00:23:22,280 --> 00:23:22,960 FORCE. 585 00:23:22,960 --> 00:23:24,480 EXPERTISE IN MICRO BIOLOGY AND 586 00:23:24,480 --> 00:23:27,960 JOINS US FROM HHS, OFFICE OF 587 00:23:27,960 --> 00:23:29,080 FAMILIES AND EVALUATION. 588 00:23:29,080 --> 00:23:32,360 AND NEXT SLIDE PLEASE, LAST 589 00:23:32,360 --> 00:23:35,360 BUT NOT LEAST, KATHY JOINS US 590 00:23:35,360 --> 00:23:37,520 AS STAFF ASSISTANT PRIMARILY 591 00:23:37,520 --> 00:23:39,800 SUPPORTING CRITICAL FUNCTIONS 592 00:23:39,800 --> 00:23:41,440 FOR HSR, JOINS US FROM AN 593 00:23:41,440 --> 00:23:42,240 INSURANCE COMPANY WHERE SHE 594 00:23:42,240 --> 00:23:46,080 WAS AN UNDER WRITING 595 00:23:46,080 --> 00:23:48,640 SPECIALIST, SERVES AS SUMMER 596 00:23:48,640 --> 00:23:52,120 ADMINISTRATIVE INTERN AND HAS 597 00:23:52,120 --> 00:23:59,120 A BACHELOR OF ARTS. 598 00:23:59,120 --> 00:23:59,520 [INAUDIBLE] 599 00:23:59,520 --> 00:24:01,840 >>ALL RIGHT, THANK YOU, GOOD 600 00:24:01,840 --> 00:24:03,960 MORNING, EVERYBODY, I AM 601 00:24:03,960 --> 00:24:06,000 ELLIOT, DIRECTOR OF THE 602 00:24:06,000 --> 00:24:07,960 DIVISION OF NEUROSCIENCE AND I 603 00:24:07,960 --> 00:24:09,800 WILL USE MY PLACE HERE TO 604 00:24:09,800 --> 00:24:11,280 INTRODUCE THE NEW RECRUITS TO 605 00:24:11,280 --> 00:24:14,400 THE POSITION OF NEUROSCIENCE 606 00:24:14,400 --> 00:24:15,760 STARTING WITH CASSIE GREEN, 607 00:24:15,760 --> 00:24:18,640 JOINING US AS A PROGRAM 608 00:24:18,640 --> 00:24:20,800 ANALYST, WORKING ON THE 609 00:24:20,800 --> 00:24:22,840 DIRECTOR'S OFFICE TOGETHER 610 00:24:22,840 --> 00:24:25,320 WITH ME AND JENNY LARKIN AND 611 00:24:25,320 --> 00:24:29,720 SHE WILL BE PROVIDING 612 00:24:29,720 --> 00:24:31,120 PROGRAMATIC SUPPORT INCLUDING 613 00:24:31,120 --> 00:24:31,680 FAILURE ANALYSIS AND 614 00:24:31,680 --> 00:24:34,360 MANAGEMENT OF A NUMBER OF 615 00:24:34,360 --> 00:24:35,680 FUNDING OPPORTUNITIES. 616 00:24:35,680 --> 00:24:38,960 SHE COMES FROM NHLBI AND HAS 617 00:24:38,960 --> 00:24:40,680 ALREADY DONE REALLY TREMENDOUS 618 00:24:40,680 --> 00:24:42,480 AMOUNT OF WORK. 619 00:24:42,480 --> 00:24:48,240 NEXT WE HAVE MAYA WHO JOINS US 620 00:24:48,240 --> 00:24:50,360 FROM NIAAD AND IS AN 621 00:24:50,360 --> 00:24:52,080 IMMUNOLOGIST WITH TRAINING 622 00:24:52,080 --> 00:24:56,080 FROM NYU AND YALE UNIVERSITY 623 00:24:56,080 --> 00:24:58,240 WITH TREMENDOUS EXPERIENCE ON 624 00:24:58,240 --> 00:25:01,400 VIROLOGY, TUMOR BIOLOGY AND SO 625 00:25:01,400 --> 00:25:04,200 ON AND SHE IS JOINING THE 626 00:25:04,200 --> 00:25:05,920 PROGRAM DIRECTOR IN THE 627 00:25:05,920 --> 00:25:08,920 NEUROBIOLOGY OF AGING AND 628 00:25:08,920 --> 00:25:09,680 NEUROREDEGENERATION BRANCH 629 00:25:09,680 --> 00:25:11,480 WHERE SHE WILL BE OVERSEEING 630 00:25:11,480 --> 00:25:14,440 ALL THE PROGRAMS ON 631 00:25:14,440 --> 00:25:16,000 IMMUNOLOGY, VIROLOGY INCLUDING 632 00:25:16,000 --> 00:25:19,280 HIV, COVID AND SO ON. 633 00:25:19,280 --> 00:25:23,920 AND NEXT WE HAVE KANG JOINING 634 00:25:23,920 --> 00:25:28,280 US FROM THE ALL OF US PROGRAM 635 00:25:28,280 --> 00:25:31,400 FROM NIHOD AND KANG IS 636 00:25:31,400 --> 00:25:35,720 ACTUALLY GOING TO BE OUR NEW 637 00:25:35,720 --> 00:25:39,120 DOC DIRECTOR FOR NIAS AND ALSO 638 00:25:39,120 --> 00:25:40,360 HELPING COORDINATING OWL THE 639 00:25:40,360 --> 00:25:44,240 DATA SHARING AND ALL THE OTHER 640 00:25:44,240 --> 00:25:46,640 PROCESSES RELATED TO GENE THOM 641 00:25:46,640 --> 00:25:50,000 MIX DATA. 642 00:25:50,000 --> 00:25:58,160 SHE HAS DEGREES -- GENOMICS 643 00:25:58,160 --> 00:26:00,080 DATA, DEGREES FROM HOWARD 644 00:26:00,080 --> 00:26:00,600 UNIVERSITY. 645 00:26:00,600 --> 00:26:03,840 NEXT SLIDE, PLEASE. 646 00:26:03,840 --> 00:26:09,080 AND MOST RECENTLY WE HAVE 647 00:26:09,080 --> 00:26:12,000 JOSLYN RIVER JOINING US, PART 648 00:26:12,000 --> 00:26:14,120 OF THE BEHAVIORAL AUTISTIC 649 00:26:14,120 --> 00:26:15,520 SCIENCE BRANCH WHERE SHE HAS 650 00:26:15,520 --> 00:26:17,560 BEEN PROVIDING SUPPORT TO THE 651 00:26:17,560 --> 00:26:19,800 PROGRAM DIRECTOR ACROSS 652 00:26:19,800 --> 00:26:22,400 MULTIPLE BRANCHES IN DATA 653 00:26:22,400 --> 00:26:23,520 MANAGEMENT, SHARING, 654 00:26:23,520 --> 00:26:24,360 EVALUATION, CLINICAL TRIAL 655 00:26:24,360 --> 00:26:28,080 MONITORING AND SO ON. 656 00:26:28,080 --> 00:26:32,120 JOINS US FROM UPENN AND PRIOR 657 00:26:32,120 --> 00:26:34,080 TO THAT, JUSTIN HAS DEGREES 658 00:26:34,080 --> 00:26:36,880 FROM IOWA UNIVERSITY AND 659 00:26:36,880 --> 00:26:37,880 PRINCE TON UNIVERSITY. 660 00:26:37,880 --> 00:26:41,720 AND LAST BUT NOT LEAST, WE 661 00:26:41,720 --> 00:26:42,960 HAVE BROOK TO JOINS US 662 00:26:42,960 --> 00:26:45,160 ACTUALLY FROM THE POSTAL 663 00:26:45,160 --> 00:26:47,640 SERVICE AND SHE IS PROVIDING 664 00:26:47,640 --> 00:26:49,280 SUPPORT ON TRAVEL COORDINATION 665 00:26:49,280 --> 00:26:56,680 AND A NUMBER IT HAVE OTHER 666 00:26:56,680 --> 00:26:58,400 INTERNAL OFFICES AND DIVISION 667 00:26:58,400 --> 00:27:00,080 FUNCTIONS RELATED TO OFFICE 668 00:27:00,080 --> 00:27:01,040 ADMINISTRATION AND SHE IS IN 669 00:27:01,040 --> 00:27:02,800 THE OFFICE OF THE DIRECTOR. 670 00:27:02,800 --> 00:27:04,680 SO THANK YOU VERY MUCH AND 671 00:27:04,680 --> 00:27:14,920 WELCOME TO ALL OF THEM. 672 00:27:14,920 --> 00:27:15,320 [APPLAUSE] 673 00:27:15,320 --> 00:27:16,760 >>ALL RIGHT, NEXT UP IS THE 674 00:27:16,760 --> 00:27:21,400 DIVISION OF EXTRA MURAL 675 00:27:21,400 --> 00:27:22,800 ACTIVITY WITH KEN AS DIRECTOR 676 00:27:22,800 --> 00:27:24,200 AND WE HAVE BEEN VERY 677 00:27:24,200 --> 00:27:26,280 FORTUNATE THIS ROUND TO HIRE 678 00:27:26,280 --> 00:27:27,400 SOME REALLY OUTSTANDING NEW 679 00:27:27,400 --> 00:27:31,000 STAFF SO I WOULD LIKE YOU ALL 680 00:27:31,000 --> 00:27:31,920 TO WELCOME THEM. 681 00:27:31,920 --> 00:27:35,880 FIRST OFF IS TERESA LING, 682 00:27:35,880 --> 00:27:36,560 HEALTH SCIENCE ADMINISTRATOR 683 00:27:36,560 --> 00:27:38,120 IN THE OFFICE OF THE DIRECTOR 684 00:27:38,120 --> 00:27:43,520 AND SHE JOINS US FROM THE BDIT 685 00:27:43,520 --> 00:27:46,440 IN SUPPORT OF THE WALTER REED 686 00:27:46,440 --> 00:27:47,720 INSTITUTE OF RESEARCH AND WILL 687 00:27:47,720 --> 00:27:49,880 NOW SERVE AS ONE OF OUR 688 00:27:49,880 --> 00:27:51,520 REFERRAL LIAISONS FOR OUR 689 00:27:51,520 --> 00:27:51,880 INSTITUTE. 690 00:27:51,880 --> 00:27:54,840 I THINK TERESA YOU ARE HERE? 691 00:27:54,840 --> 00:28:00,200 YOU WANT TO GIVE A WAIVE? 692 00:28:00,200 --> 00:28:07,440 THANK YOU. 693 00:28:07,440 --> 00:28:09,400 NEXT WE HAVE SHERYL IN THE 694 00:28:09,400 --> 00:28:12,040 OFFICE OF THE CHIEF OF 695 00:28:12,040 --> 00:28:13,720 CLINICAL RESEARCH, THIS IS A 696 00:28:13,720 --> 00:28:15,680 NEW POSITION CREATED TO 697 00:28:15,680 --> 00:28:17,520 SUPPORT OUR CLINICAL RESEARCH 698 00:28:17,520 --> 00:28:19,320 THROUGHOUT THE INSTITUTE. 699 00:28:19,320 --> 00:28:20,360 WE WELCOME SHARON SMITH AND 700 00:28:20,360 --> 00:28:22,920 SHE IS GOING TO OVERSEE AND 701 00:28:22,920 --> 00:28:25,720 COORDINATE THE DEVELOPMENT AND 702 00:28:25,720 --> 00:28:27,120 IMPLEMENTATION TO ENHANCE 703 00:28:27,120 --> 00:28:28,840 DIVERSITY, EQUITY AND 704 00:28:28,840 --> 00:28:30,800 INCLUSION FOR NIA FUNDED 705 00:28:30,800 --> 00:28:32,080 CLINICAL TRIALS AND ALSO GOING 706 00:28:32,080 --> 00:28:36,760 TO BE THE MAJOR CONTACT FOR 707 00:28:36,760 --> 00:28:39,120 OUR CLINICAL RESEARCH 708 00:28:39,120 --> 00:28:40,120 OPERATIONS MANAGEMENT SYSTEM 709 00:28:40,120 --> 00:28:42,080 THAT MANAGES ALL OF OUR 710 00:28:42,080 --> 00:28:43,600 CLINICAL TRIALS HERE AT THE 711 00:28:43,600 --> 00:28:45,440 INSTITUTE AND SHE'S JOINING US 712 00:28:45,440 --> 00:28:48,520 FROM THE MENTAL HEALTH 713 00:28:48,520 --> 00:28:48,880 INSTITUTE. 714 00:28:48,880 --> 00:28:50,560 NEXT SLIDE. 715 00:28:50,560 --> 00:28:53,200 WE HAVE OUR SCIENTIFIC REVIEW 716 00:28:53,200 --> 00:28:54,920 BRANCH WAS ABLE TO HIRE 717 00:28:54,920 --> 00:28:57,080 SEVERAL NEW SCIENTIFIC REVIEW 718 00:28:57,080 --> 00:28:57,440 OFFICERS. 719 00:28:57,440 --> 00:29:00,880 FIRST OFF, WE HAVE CAITLYN 720 00:29:00,880 --> 00:29:01,240 HARDELL. 721 00:29:01,240 --> 00:29:03,120 SHE IS JOINING US FROM THE 722 00:29:03,120 --> 00:29:04,680 CANCER INSTITUTE AND WILL BE 723 00:29:04,680 --> 00:29:07,440 ONE OF OUR NEW SCIENTIFIC 724 00:29:07,440 --> 00:29:09,000 REVIEW OFFICERS IN THE 725 00:29:09,000 --> 00:29:11,920 INFORMATION RESOURCES AND 726 00:29:11,920 --> 00:29:13,880 POLICY SECTION. 727 00:29:13,880 --> 00:29:15,920 WE HAVE MARIELLE DIAZ JOINING 728 00:29:15,920 --> 00:29:18,440 US FROM GEORGE WASHINGTON 729 00:29:18,440 --> 00:29:18,880 UNIVERSITY. 730 00:29:18,880 --> 00:29:21,640 SHE IS GOING TO IT BE A 731 00:29:21,640 --> 00:29:23,440 SCIENTIFIC REVIEW OFFICER IN 732 00:29:23,440 --> 00:29:25,040 THE SPECIAL REVIEW INFORMATION 733 00:29:25,040 --> 00:29:30,080 RESOURCES AND POLICY SECTION 734 00:29:30,080 --> 00:29:30,360 ALSO. 735 00:29:30,360 --> 00:29:32,280 NEXT SLIDE. 736 00:29:32,280 --> 00:29:35,680 WE HAVE Dr. NAZAR ACONDA AND 737 00:29:35,680 --> 00:29:40,120 HE WILL BE A NEW SRO IN THE 738 00:29:40,120 --> 00:29:41,960 CLINICAL SCIENCES SECTION IN 739 00:29:41,960 --> 00:29:43,200 OUR SCIENTIFIC REVIEW BRANCH 740 00:29:43,200 --> 00:29:45,400 AND HE JOINS US FROM THE 741 00:29:45,400 --> 00:29:48,560 UNIVERSITY OF CENTRAL FLORIDA. 742 00:29:48,560 --> 00:29:53,880 AND WE HAVE CHRISTINA FOWLES 743 00:29:53,880 --> 00:29:57,520 AND SHE IS A PATHWAY STUDENT 744 00:29:57,520 --> 00:30:00,800 AND WILL BE PART OF OUR 745 00:30:00,800 --> 00:30:03,800 SUPPORT STAFF FOR THE 746 00:30:03,800 --> 00:30:04,760 SCIENTIFIC REVIEW BRANCH. 747 00:30:04,760 --> 00:30:05,360 NEXT SLIDE. 748 00:30:05,360 --> 00:30:08,800 WE HAVE SEVERAL NEW HIRES IN 749 00:30:08,800 --> 00:30:10,600 OUR GRANTS AND CONTRACTS 750 00:30:10,600 --> 00:30:11,360 MANAGEMENT BRANCH. 751 00:30:11,360 --> 00:30:16,800 FIRST OFF WE HAVE BRIA HARRIS, 752 00:30:16,800 --> 00:30:19,080 SHE WILL BE A NEW GRANTS 753 00:30:19,080 --> 00:30:19,800 MANAGEMENT SPECIALIST JOINING 754 00:30:19,800 --> 00:30:22,640 US FROM THE OFFICE OF PLANNING 755 00:30:22,640 --> 00:30:26,760 AND BUDGET FROM GEORGIA. 756 00:30:26,760 --> 00:30:29,280 AND TELLEHA HOWARD, NEW GRANTS 757 00:30:29,280 --> 00:30:30,400 MANAGEMENT SPECIALIST AND 758 00:30:30,400 --> 00:30:33,920 JOINING US FROM THE CENTER OF 759 00:30:33,920 --> 00:30:35,520 DISEASE CONTROL AND 760 00:30:35,520 --> 00:30:35,920 PREVENTION. 761 00:30:35,920 --> 00:30:38,720 NEXT SLIDE. 762 00:30:38,720 --> 00:30:40,320 YOLANDA JONES, ANOTHER GRANTS 763 00:30:40,320 --> 00:30:41,120 MANAGEMENT SPECIALIST JOINING 764 00:30:41,120 --> 00:30:42,640 US FROM THE STATE OF 765 00:30:42,640 --> 00:30:43,880 CALIFORNIA UNIFIED SCHOOL 766 00:30:43,880 --> 00:30:46,840 DISTRICT AND JESSICA JOSEPH, 767 00:30:46,840 --> 00:30:48,080 ANOTHER GRANTS MANAGEMENT 768 00:30:48,080 --> 00:30:54,560 SPECIALIST WHO JOINS US FROM 769 00:30:54,560 --> 00:30:56,040 THE TEAM OF INFECTIOUS 770 00:30:56,040 --> 00:30:56,440 DISEASES. 771 00:30:56,440 --> 00:30:57,080 NEXT SLIDE. 772 00:30:57,080 --> 00:31:01,720 WE HAVE TRACY McGRAW, GRANTS 773 00:31:01,720 --> 00:31:02,440 MANAGEMENT SPECIALIST JOINING 774 00:31:02,440 --> 00:31:08,640 US FROM THE CANCER INSTITUTE 775 00:31:08,640 --> 00:31:11,120 AND CAROLINE MIKLOS JOINING US 776 00:31:11,120 --> 00:31:12,920 FROM JOHNS HOPKINS UNIVERSITY. 777 00:31:12,920 --> 00:31:15,080 NEXT WE HAVE CAROLYN PHILIPPS 778 00:31:15,080 --> 00:31:17,320 WHO WILL BE STAFF ASSISTANT IN 779 00:31:17,320 --> 00:31:21,720 THE GRANTS MANAGEMENT BRANCH 780 00:31:21,720 --> 00:31:25,920 ASSISTING TRACY LAFFERTY, OUR 781 00:31:25,920 --> 00:31:28,360 CHIEF GM O. 782 00:31:28,360 --> 00:31:29,640 KRISTINA SMITH ANOTHER GRANTS 783 00:31:29,640 --> 00:31:30,760 MANAGEMENT SPECIALIST JOINING 784 00:31:30,760 --> 00:31:32,480 US FROM A NONPROFIT 785 00:31:32,480 --> 00:31:33,880 ORGANIZATION AS PROGRAM 786 00:31:33,880 --> 00:31:35,920 COORDINATOR AND TIFFANY 787 00:31:35,920 --> 00:31:37,440 SWANSON FINALLY JOINS US FROM 788 00:31:37,440 --> 00:31:38,720 MORGUE DAN STATE UNIVERSITY. 789 00:31:38,720 --> 00:31:43,120 SO YOU CAN SEE WE HIRED A 790 00:31:43,120 --> 00:31:45,760 LARGE COHORT OF GRANTS 791 00:31:45,760 --> 00:31:47,120 MANAGEMENT SPECIALISTS TO 792 00:31:47,120 --> 00:31:49,200 HANDLE THE HUGE LOAD OF GRANTS 793 00:31:49,200 --> 00:31:52,040 ISSUES THAT WE HAVE FOR THE 794 00:31:52,040 --> 00:31:53,800 INSTITUTE THAT IS CREATED BY 795 00:31:53,800 --> 00:31:55,240 THE INCREASE IN BUDGET SO 796 00:31:55,240 --> 00:31:57,960 WE'RE DOING SO MANY MORE 797 00:31:57,960 --> 00:31:58,480 ACTIONSS. 798 00:31:58,480 --> 00:32:05,720 THIS WAS A NEW CONCEPT THAT WE 799 00:32:05,720 --> 00:32:09,640 HIRED THE ENTIRE COHORT AS 800 00:32:09,640 --> 00:32:10,880 GRANTS MANAGEMENT SPECIALISTS 801 00:32:10,880 --> 00:32:13,880 TO KEEP THE PIPELINE GOING AT 802 00:32:13,880 --> 00:32:15,920 THE INSTITUTE. 803 00:32:15,920 --> 00:32:17,680 NEXT SLIDE, PLEASE? 804 00:32:17,680 --> 00:32:19,040 >>GOOD MORNING I AM KAREN AND 805 00:32:19,040 --> 00:32:22,840 I AM HERE ON BEHALF OF PATRICK 806 00:32:22,840 --> 00:32:23,840 SHERIDAN, EXECUTIVE OFFICER 807 00:32:23,840 --> 00:32:26,560 WHO ISN'T HERE THIS MORNING. 808 00:32:26,560 --> 00:32:28,600 HERE TO INTRODUCE YOU TO THE 809 00:32:28,600 --> 00:32:30,040 OFFICE OF ADMINISTRATIVE 810 00:32:30,040 --> 00:32:32,960 MANAGEMENT NEW STAFF IN THE 811 00:32:32,960 --> 00:32:33,640 WORKFORCE ADMINISTRATOR 812 00:32:33,640 --> 00:32:34,040 BRANCH. 813 00:32:34,040 --> 00:32:39,440 WE HAVE ERIN GOTZENS, NEW 814 00:32:39,440 --> 00:32:45,200 ADMINISTRATIVE OFFICER, JOINS 815 00:32:45,200 --> 00:32:47,720 US FROM REAL ESTATE TITLE 816 00:32:47,720 --> 00:32:50,200 SERVICES AND MARISA MULLEN, 817 00:32:50,200 --> 00:32:52,440 JOINS US FROM NIAID. 818 00:32:52,440 --> 00:32:53,080 NEXT SLIDE. 819 00:32:53,080 --> 00:33:00,800 IN THE TECHNOLOGY BRANCH, WE 820 00:33:00,800 --> 00:33:03,360 HAVE KRISTEN JOINING US AS 821 00:33:03,360 --> 00:33:06,040 PROGRESS SPECIALIST AND WE 822 00:33:06,040 --> 00:33:07,920 ALSO HAVE WENDY SCHNEIDER, 823 00:33:07,920 --> 00:33:10,280 JOINING ALWAYS FROM FAMILY 824 00:33:10,280 --> 00:33:13,040 SERVICES OF RHODE ISLAND AND 825 00:33:13,040 --> 00:33:15,160 OMAR SET TELLS, NEW IT 826 00:33:15,160 --> 00:33:16,600 SPECIALIST AND SECURITY 827 00:33:16,600 --> 00:33:18,880 OFFICER AT THE BALTIMORE BIC 828 00:33:18,880 --> 00:33:28,920 BUILDING AND JOINS US FROM 829 00:33:28,920 --> 00:33:29,720 'TIS DETAIL-- TISTA. 830 00:33:29,720 --> 00:33:31,960 >>SO FROM THE OFFICE OF 831 00:33:31,960 --> 00:33:33,800 DIRECTOR, BESIDES MYSELF BEING 832 00:33:33,800 --> 00:33:39,120 RELATIVELY NEW, WE HAVE 833 00:33:39,120 --> 00:33:42,000 ANOTHER NEW PHYSICIANS, 834 00:33:42,000 --> 00:33:43,680 MICHELLE NEWELL, STAFF 835 00:33:43,680 --> 00:33:47,800 ASSISTANT SERVING THE DEPUTY 836 00:33:47,800 --> 00:33:49,640 DIRECTOR AND PRIOR TO COMING 837 00:33:49,640 --> 00:33:51,560 TO NIA WAS AN OFFICE MANAGER 838 00:33:51,560 --> 00:33:57,320 AT A LOCAL MEDICAL PRACTICE 839 00:33:57,320 --> 00:33:59,680 AND JOINS IS A GRADUATE OF 840 00:33:59,680 --> 00:34:05,240 CLEMSON UNIVERSITY WITH A 841 00:34:05,240 --> 00:34:06,160 BACKGROUND IN BIOLOGY. 842 00:34:06,160 --> 00:34:08,160 >>HELLO, I AM COURTNEY WALL, 843 00:34:08,160 --> 00:34:09,800 DEPUTY DIRECTOR FROM THE 844 00:34:09,800 --> 00:34:11,600 OFFICE OF LEGISLATION, POLICY 845 00:34:11,600 --> 00:34:14,040 AND INTERNATIONAL ACTIVITIES 846 00:34:14,040 --> 00:34:17,880 HERE TO INTRODUCE SHANTE 847 00:34:17,880 --> 00:34:19,760 ALERTE WHO JOINED OUR STAFF 848 00:34:19,760 --> 00:34:20,680 BACK IN FEBRUARY. 849 00:34:20,680 --> 00:34:24,280 SHE IS ALSO EFFECTIVELY 850 00:34:24,280 --> 00:34:27,040 MANAGING THE ADMINISTRATIVE 851 00:34:27,040 --> 00:34:28,680 AND OPERATIONAL FUNCTIONS OF 852 00:34:28,680 --> 00:34:31,280 OUR OFFICE AND HANDLING 853 00:34:31,280 --> 00:34:32,360 SEVERAL HIGH-LEVEL PROJECTS 854 00:34:32,360 --> 00:34:34,680 FOR US AND JOINS US FROM NIH 855 00:34:34,680 --> 00:34:36,960 ALL OF US RESEARCH PROGRAM AND 856 00:34:36,960 --> 00:34:38,480 CAN'T EMPHASIZE ENOUGH HOW 857 00:34:38,480 --> 00:34:40,760 CRITICAL HER ROLE HAS BEEN 858 00:34:40,760 --> 00:34:44,560 WITH THE NEEDING QUICK 859 00:34:44,560 --> 00:34:47,320 TURNAROUND ON SOME PROJECTS. 860 00:34:47,320 --> 00:34:47,640 THANKS. 861 00:34:47,640 --> 00:34:48,680 >>CINDY McCON NELL, 862 00:34:48,680 --> 00:34:50,440 DIRECTOR OF THE OFFICE OF 863 00:34:50,440 --> 00:34:53,960 COMMUNICATIONS AND PUBLIC 864 00:34:53,960 --> 00:34:57,560 LIAISON. 865 00:34:57,560 --> 00:35:05,280 WE WELCOMED RECENTLY FEDORA 866 00:35:05,280 --> 00:35:08,840 BRAVERMAN, SHE IS BI LINGUAL 867 00:35:08,840 --> 00:35:12,240 AND WILL BE SERVING AS HEALTH 868 00:35:12,240 --> 00:35:13,040 COMMUNICATIONS SPECIALIST TO 869 00:35:13,040 --> 00:35:15,400 HELP WITH THE SPANISH LANGUAGE 870 00:35:15,400 --> 00:35:17,400 HEALTH COMMUNICATIONS WE OFFER 871 00:35:17,400 --> 00:35:19,840 TO OUR AUDIENCE. 872 00:35:19,840 --> 00:35:27,520 FEDORA WAS PREVIOUSLY AT THE 873 00:35:27,520 --> 00:35:29,920 NATIONAL CANCER INSTITUTE. 874 00:35:29,920 --> 00:35:33,680 >>HI, SO NIA, THE ISC IS 875 00:35:33,680 --> 00:35:42,160 QUITE ACTIVE AND HAVE GROWING 876 00:35:42,160 --> 00:35:48,000 AND THESE ARE THE THREE NEW 877 00:35:48,000 --> 00:35:49,960 ADMINISTRATIVE OFFICERS, 878 00:35:49,960 --> 00:35:53,200 JENNIFER BETTER REWHO JOINS US 879 00:35:53,200 --> 00:36:03,760 FROM THE ARMY U.S. CORPS OF 880 00:36:04,360 --> 00:36:04,880 ENGINEERS, WILLIAM HOFF 881 00:36:04,880 --> 00:36:08,400 JOINING US FROM THE DEPARTMENT 882 00:36:08,400 --> 00:36:12,040 OF JUSTICE AND JESSICA 883 00:36:12,040 --> 00:36:18,240 WHITAKER, JOINING US FROM THE 884 00:36:18,240 --> 00:36:18,560 NIGMS. 885 00:36:18,560 --> 00:36:19,440 NEXT SLIDE. 886 00:36:19,440 --> 00:36:30,000 SO WE HAVE TWO NEW HIRINGS, 887 00:36:32,120 --> 00:36:36,680 KELLI VAN ZEE, JOINS US FROM 888 00:36:36,680 --> 00:36:43,240 THE NATIONAL PARK SERVICE, 889 00:36:43,240 --> 00:36:51,080 VERONICA RYAN FROM NINDS AND 890 00:36:51,080 --> 00:36:52,200 LAUREL SCREVEN, SCIENTIFIC 891 00:36:52,200 --> 00:36:53,960 PROJECT MANAGER AND JOINS US 892 00:36:53,960 --> 00:36:56,400 FROM KELLY GOVERNMENT 893 00:36:56,400 --> 00:36:57,400 SOLUTIONS. 894 00:36:57,400 --> 00:36:57,720 NEXT. 895 00:36:57,720 --> 00:37:02,880 WE ARE NEW SERVICES TO HANDLE 896 00:37:02,880 --> 00:37:09,880 THE PROJECTS IN THE COMMUNITY 897 00:37:09,880 --> 00:37:11,720 AND JADE TALMADGE JOINS US 898 00:37:11,720 --> 00:37:16,720 FROM WALT PER READ NATIONAL 899 00:37:16,720 --> 00:37:27,240 MILITARY MEDICAL CENTER AND 900 00:37:28,160 --> 00:37:28,800 DIMITRIOS TSITSIPATIS, 901 00:37:28,800 --> 00:37:32,480 RESEARCH FELLOW, EXPERT IN RNA 902 00:37:32,480 --> 00:37:33,400 SEQUENCING PROJECTS. 903 00:37:33,400 --> 00:37:36,080 NEXT SLIDE. 904 00:37:36,080 --> 00:37:41,440 WE HAVE CAIO MAZUCANTI, 905 00:37:41,440 --> 00:37:42,960 RESEARCH FELLOW JOINING US 906 00:37:42,960 --> 00:37:48,320 FROM THE UNIVERSITY OF SAO 907 00:37:48,320 --> 00:37:48,680 PAULO. 908 00:37:48,680 --> 00:37:53,640 WE HAVE LESLIE VUNCANNON, 909 00:37:53,640 --> 00:37:57,080 EDITORIAL ASSISTANT IN 910 00:37:57,080 --> 00:37:58,680 TRANSLATIONAL GERONTOLOGY 911 00:37:58,680 --> 00:38:00,960 BRANCH AND WILL BE HELPING US 912 00:38:00,960 --> 00:38:04,400 WITH ALL THE ADVANCED 913 00:38:04,400 --> 00:38:06,240 AUTOMATION TECHNOLOGY GROWING 914 00:38:06,240 --> 00:38:08,720 IN NIH. 915 00:38:08,720 --> 00:38:13,520 NEXT SLIDE. 916 00:38:13,520 --> 00:38:23,560 SO WE HAVE SYED ABBAS BUKHARI 917 00:38:23,560 --> 00:38:29,040 AS STAFF SCIENTIST WORKING ON 918 00:38:29,040 --> 00:38:33,760 GENETIC DATA AND FLOW 919 00:38:33,760 --> 00:38:37,560 CYTOMETRY DATA. 920 00:38:37,560 --> 00:38:40,480 FATIMA BRAIKIA WILL BE 921 00:38:40,480 --> 00:38:47,960 RESEARCH FELLOW WORKING 922 00:38:47,960 --> 00:38:50,880 CLOSELY WORKING WITH 923 00:38:50,880 --> 00:38:53,080 LABORATORY OF MOLECULAR 924 00:38:53,080 --> 00:38:54,120 BIOLOGY AND IMMUNOLOGY. 925 00:38:54,120 --> 00:38:56,880 NEXT SLIDE. 926 00:38:56,880 --> 00:39:07,440 AND THEN TWO MORE JOINING THE 927 00:39:08,720 --> 00:39:09,640 INSTITUTE, MICHLYO IBA, 928 00:39:09,640 --> 00:39:15,640 JOINING US FROM KELLY 929 00:39:15,640 --> 00:39:17,400 GOVERNMENT SOLUTIONS AND VERY 930 00:39:17,400 --> 00:39:20,600 MUCH INTERESTED IN 931 00:39:20,600 --> 00:39:21,320 INFLAMMATION ESPECIALLY 932 00:39:21,320 --> 00:39:25,640 PARKINSON'S DISEASE AND MINKYO 933 00:39:25,640 --> 00:39:27,040 SONG, TENURE TRACK 934 00:39:27,040 --> 00:39:28,160 INVESTIGATOR JOINING US FROM 935 00:39:28,160 --> 00:39:29,520 NCI AND I THINK THAT IS IT. 936 00:39:29,520 --> 00:39:30,760 >>THANK YOU VERY MUCH AND 937 00:39:30,760 --> 00:39:32,320 PLEASE SEND A WARM WELCOME TO 938 00:39:32,320 --> 00:39:36,400 OUR NEW STAFF HERE AT NIA. 939 00:39:36,400 --> 00:39:40,000 NOW WE HAVE TIME FOR QUESTIONS 940 00:39:40,000 --> 00:39:42,280 FOR Dr. HODES REGARDING HIS 941 00:39:42,280 --> 00:39:48,840 PRESENTATION EARLIER. 942 00:39:48,840 --> 00:39:49,520 ANY QUESTIONS? 943 00:39:49,520 --> 00:39:50,320 >>I WILL COVER ANYTHING YOU 944 00:39:50,320 --> 00:39:57,000 WOULD LIKE TO BRING UP. 945 00:39:57,000 --> 00:40:01,720 >>YES, NIH HAS A LOT GOING ON 946 00:40:01,720 --> 00:40:03,680 IN ALZHEIMER'S'S RELATE 947 00:40:03,680 --> 00:40:07,360 DISORDERS AND THE INTRAMURAL 948 00:40:07,360 --> 00:40:09,640 BRANCH, YOU HEARD ABOUT KARS 949 00:40:09,640 --> 00:40:11,680 REALLY GETTING OFF THE GROUND, 950 00:40:11,680 --> 00:40:15,600 A O C PROGRAMS AND A NUMBER OF 951 00:40:15,600 --> 00:40:16,720 OTHER PROGRAMS IN INDIVIDUAL 952 00:40:16,720 --> 00:40:18,400 STATIONS. 953 00:40:18,400 --> 00:40:20,800 IS THERE A COORDINATED METHOD 954 00:40:20,800 --> 00:40:22,880 OF MAKING SURE THAT THERE IS 955 00:40:22,880 --> 00:40:25,960 NOT DUPLICATION AND THAT 956 00:40:25,960 --> 00:40:27,360 EVERYTHING IS COVERED? 957 00:40:27,360 --> 00:40:31,720 YOU KNOW, ACROSS ALL THESE 958 00:40:31,720 --> 00:40:32,400 INITIATIVES? 959 00:40:32,400 --> 00:40:33,320 >>YEAH, IT IS A GREAT 960 00:40:33,320 --> 00:40:33,920 QUESTION. 961 00:40:33,920 --> 00:40:36,520 SO THERE ARE A NUMBER OF 962 00:40:36,520 --> 00:40:39,080 PLACES WHERE OUR EFFORTS IN 963 00:40:39,080 --> 00:40:45,760 ALZHEIMER'S COLE LESS AND 964 00:40:45,760 --> 00:40:50,320 COALESCE AND ONE OF THEM IS 965 00:40:50,320 --> 00:40:52,400 THE STRATEGIC BY PASS PROJECT. 966 00:40:52,400 --> 00:40:55,560 FOR THOSE NOT FAMILIAR, THE 967 00:40:55,560 --> 00:40:56,640 NATIONAL ALZHEIMER'S PROJECT 968 00:40:56,640 --> 00:41:00,600 ACT, THERE IS A REQUIREMENT 969 00:41:00,600 --> 00:41:03,120 FOR NIH, A NIH DIRECTOR EACH 970 00:41:03,120 --> 00:41:05,080 YEAR TO SUBMIT TO CONGRESS 971 00:41:05,080 --> 00:41:07,800 WHAT IS CALLED A PROFESSIONAL 972 00:41:07,800 --> 00:41:11,200 JUDGMENT BUDGET AND ENUMERATE 973 00:41:11,200 --> 00:41:13,000 THE FUNDS NECESSARY ABOVE 974 00:41:13,000 --> 00:41:17,600 CURRENT FUNDING LEVELS IN 975 00:41:17,600 --> 00:41:28,200 ORDER TO OPT HALLE PURSUE THE 976 00:41:30,480 --> 00:41:35,080 ALZHEIMER'-- OPTIMALLY PURSUE 977 00:41:35,080 --> 00:41:35,680 ALZHEIMER'S. 978 00:41:35,680 --> 00:41:37,120 THIS EACH YEAR GENERATES A 979 00:41:37,120 --> 00:41:38,440 SERIES OF MILESTONES THAT ARE 980 00:41:38,440 --> 00:41:40,640 THE OUTCOME OF IDENTIFIED GAPS 981 00:41:40,640 --> 00:41:42,920 AND OPPORTUNITIES FROM SUCH 982 00:41:42,920 --> 00:41:44,520 EXERCISES AND INPUT AT THE 983 00:41:44,520 --> 00:41:46,840 SUMMIT AND THE SUMMIT AS YOU 984 00:41:46,840 --> 00:41:50,360 SEE, THERE ARE THREE FLAVORS 985 00:41:50,360 --> 00:41:54,480 OF SUMMITS, THE ALZHEIMER'S 986 00:41:54,480 --> 00:41:57,000 SUMMIT, THE RESOURCES SUMMIT 987 00:41:57,000 --> 00:41:58,320 AND THE THIRD ONE THAT 988 00:41:58,320 --> 00:41:59,760 OCCURRED THIS YEAR AND AFTER 989 00:41:59,760 --> 00:42:03,200 EACH, THERE IS A SECTION OF 990 00:42:03,200 --> 00:42:05,040 RECOMMENDED OPPORTUNITIES 991 00:42:05,040 --> 00:42:06,640 TRANSLATED INTO MILESTONES. 992 00:42:06,640 --> 00:42:08,480 MILESTONES NEEDED TO ACHIEVE 993 00:42:08,480 --> 00:42:10,160 EACH OF THOSE GOALS. 994 00:42:10,160 --> 00:42:12,240 THE MILESTONES THEN ARE USED 995 00:42:12,240 --> 00:42:15,320 AS A GUIDE FOR OUR GENERATION 996 00:42:15,320 --> 00:42:18,160 OF INITIATIVES AS PART OF OUR 997 00:42:18,160 --> 00:42:19,320 INTEGRATED PLANNING PROCESS AT 998 00:42:19,320 --> 00:42:22,320 THE INSTITUTE -- I AM GIVING 999 00:42:22,320 --> 00:42:23,320 YOU THE FORMAL ASPECT BUT 1000 00:42:23,320 --> 00:42:27,120 RIGHT NOW WE ARE BUILDING 1001 00:42:27,120 --> 00:42:29,960 TOWARDS A -- NEXT MONTH OUR A 1002 00:42:29,960 --> 00:42:32,120 PLANNING RETREAT IN WHICH THE 1003 00:42:32,120 --> 00:42:33,400 WHOLE INSTITUTE GETS TOGETHER 1004 00:42:33,400 --> 00:42:37,600 AND PROBABLY IN THIS ROOM FOR 1005 00:42:37,600 --> 00:42:42,080 THREE DAYS AND LOOKS AT A 1006 00:42:42,080 --> 00:42:43,560 SERIES OF INITIATIVES FOR 1007 00:42:43,560 --> 00:42:45,360 TARGETED RESEARCH AND THESE 1008 00:42:45,360 --> 00:42:53,440 INCLUDE MANY THAT ARE NIA AAD, 1009 00:42:53,440 --> 00:42:56,400 SOME ARE NOT BUT AGAIN WITH 1010 00:42:56,400 --> 00:42:57,640 PLANNING COLLABORATION BEFORE 1011 00:42:57,640 --> 00:42:58,560 HAND AND FURTHER DISCUSSION AT 1012 00:42:58,560 --> 00:43:05,600 THE TIME OF THE RETREAT SO THE 1013 00:43:05,600 --> 00:43:07,800 BUDGET WITH FORWARD LOOKING 1014 00:43:07,800 --> 00:43:09,240 IDENTIFICATION OF PRIORITY 1015 00:43:09,240 --> 00:43:11,840 AREAS AND INTERNAL STRATEGIC 1016 00:43:11,840 --> 00:43:13,560 PLANNING PROCESS WHICH 1017 00:43:13,560 --> 00:43:16,160 INCLUDES ACTUALLY SET ASIDE 1018 00:43:16,160 --> 00:43:18,720 MISSIONS WHICH YOU KNOW WELL 1019 00:43:18,720 --> 00:43:20,040 WITH THE CONSEQUENCES BEFORE 1020 00:43:20,040 --> 00:43:23,040 WE GO FURTHER AND OVERALL 1021 00:43:23,040 --> 00:43:24,400 COMPREHENSIVE POINTS IN WHICH 1022 00:43:24,400 --> 00:43:34,920 WE EMPHASIZE OUR PLANNING 1023 00:43:35,160 --> 00:43:36,880 EFFORTS. 1024 00:43:36,880 --> 00:43:38,360 [INAUDIBLE] 1025 00:43:38,360 --> 00:43:39,000 [ OFF MIC ] 1026 00:43:39,000 --> 00:43:41,160 >>YOU KNOW WE LOOK AT THE 1027 00:43:41,160 --> 00:43:46,840 NUMBER OF PLANNING INITIATIVES 1028 00:43:46,840 --> 00:43:49,080 FROM THE STUDIES AND SUMMITS 1029 00:43:49,080 --> 00:43:51,600 AND THE OTHER ALZHEIMER'S 1030 00:43:51,600 --> 00:43:53,360 ONES, BUT SITTING DOWN AND 1031 00:43:53,360 --> 00:43:54,640 SAYING OH, I WILL TAKE THIS 1032 00:43:54,640 --> 00:43:56,960 ONE, I WILL TAKE THAT ONE, AND 1033 00:43:56,960 --> 00:43:59,040 YOU KNOW MAKING SURE THAT 1034 00:43:59,040 --> 00:44:03,800 EVERYTHING IS COVERED WITHOUT 1035 00:44:03,800 --> 00:44:04,240 DUPLICATION. 1036 00:44:04,240 --> 00:44:06,160 I THINK THEY DO OCCUR AROUND 1037 00:44:06,160 --> 00:44:08,160 THE BY PASS BUDGET STRATEGY. 1038 00:44:08,160 --> 00:44:09,600 SO EACH YEAR FOLLOWING THE 1039 00:44:09,600 --> 00:44:12,000 RETREAT, THAT IS SORT OF THE 1040 00:44:12,000 --> 00:44:17,880 TRIGGER WITH NEW OPPORTUNITIES 1041 00:44:17,880 --> 00:44:19,720 WE HAVE IDENTIFIED, WE MAKE 1042 00:44:19,720 --> 00:44:21,360 THE LINKS AVAILABLE TO A 1043 00:44:21,360 --> 00:44:23,400 MILESTONE DOCUMENT WHICH IS 1044 00:44:23,400 --> 00:44:25,800 INTENDED TO BE QUITE 1045 00:44:25,800 --> 00:44:27,080 COMPREHENSIVE, OVER 100 1046 00:44:27,080 --> 00:44:28,920 MILESTONES IN A VARIETY OF 1047 00:44:28,920 --> 00:44:35,440 AREAS THAT RANGE FROM THE MOST 1048 00:44:35,440 --> 00:44:36,960 MOLECULAR IDENTIFICATION OF 1049 00:44:36,960 --> 00:44:38,240 CLINICAL TRIALS HERE, ALL OF 1050 00:44:38,240 --> 00:44:39,040 THIS. 1051 00:44:39,040 --> 00:44:40,760 AND THEN THAT EXERCISE EACH 1052 00:44:40,760 --> 00:44:44,720 YEAR IS ONE AT WHICH THERE IS 1053 00:44:44,720 --> 00:44:50,640 A LOOK FOR, BY DEFINITION, GAS 1054 00:44:50,640 --> 00:44:52,400 OPPORTUNITIES AND AVOID 1055 00:44:52,400 --> 00:44:53,640 DUPLICATION TO BE SURE BUT I 1056 00:44:53,640 --> 00:44:57,240 THINK IN A VERY HEALTHY WAY, 1057 00:44:57,240 --> 00:44:59,280 ALWAYS OUR RESEARCH IS DRIVEN 1058 00:44:59,280 --> 00:45:01,720 BY OUR TARGET INITIATIVES THAT 1059 00:45:01,720 --> 00:45:07,320 ARE SET ASIDE AND THEN THE 1060 00:45:07,320 --> 00:45:09,320 RESEARCH AS THAT IS VERY 1061 00:45:09,320 --> 00:45:12,360 BALANCED SO WE WANT TO HAVE A 1062 00:45:12,360 --> 00:45:14,400 GUIDE BUT NOT MISS INITIATED 1063 00:45:14,400 --> 00:45:14,920 RESEARCH. 1064 00:45:14,920 --> 00:45:17,840 SO I THINK YOU ARE ASKING WHO 1065 00:45:17,840 --> 00:45:19,440 DECIDED WHAT IS COVERED OR 1066 00:45:19,440 --> 00:45:21,800 NOT, THAT FALLS IN OUR BY PASS 1067 00:45:21,800 --> 00:45:23,440 STRATEGY AND THEN OUR PLANNING 1068 00:45:23,440 --> 00:45:26,960 RETREAT WHERE ALL THE ISSUES 1069 00:45:26,960 --> 00:45:30,160 ARE THERE, HOPEFULLY WE ALL 1070 00:45:30,160 --> 00:45:35,720 WORK TOGETHER ON THIS -- 1071 00:45:35,720 --> 00:45:37,080 [INDISCERNIBLE] 1072 00:45:37,080 --> 00:45:39,480 >>MOST OF THE INTRAMURAL 1073 00:45:39,480 --> 00:45:40,640 BRANCH AS WELL? 1074 00:45:40,640 --> 00:45:42,160 >>IN TERMS OF THE REPORTING 1075 00:45:42,160 --> 00:45:43,960 AND BY PASS BUDGET, YES THAT 1076 00:45:43,960 --> 00:45:46,040 IS GOING TO BE VERY IMPORTANT 1077 00:45:46,040 --> 00:45:48,400 BUT REMEMBER BECAUSE OF 1078 00:45:48,400 --> 00:45:50,400 THEVERY DIFFERENT RULES THAT 1079 00:45:50,400 --> 00:45:53,680 GUIDE THE INTRAMURAL AND 1080 00:45:53,680 --> 00:45:54,840 EXTRAMURAL PROGRAMS, THEY FOR 1081 00:45:54,840 --> 00:45:56,800 EXAMPLE DON'T BUDGET IN THE 1082 00:45:56,800 --> 00:45:58,040 SPECIFIC DETERMINATION OF 1083 00:45:58,040 --> 00:45:59,840 WHICH ARE THEY ALLOWING FOR 1084 00:45:59,840 --> 00:46:01,840 TARGETED FUNDING IN THE 1085 00:46:01,840 --> 00:46:08,320 EXTRAMURAL COMMUNITY. 1086 00:46:08,320 --> 00:46:09,720 THE SCIENTIFIC RETREAT IS 1087 00:46:09,720 --> 00:46:10,520 EXTREMELY IMPORTANT BUT THEY 1088 00:46:10,520 --> 00:46:12,480 HAVE THE LINE ITEM IN OUR 1089 00:46:12,480 --> 00:46:13,320 BUDGET WITH THEIR RESEARCH. 1090 00:46:13,320 --> 00:46:16,440 WHAT THEY ARE DOING IS VERY 1091 00:46:16,440 --> 00:46:18,040 MUCH COORDINATED WHAT HAPPENS 1092 00:46:18,040 --> 00:46:20,160 WITH A SEPARATION OF 1093 00:46:20,160 --> 00:46:25,880 INTRAMURAL AND EXTRAMURAL 1094 00:46:25,880 --> 00:46:26,640 DECISIONAL MECHANISMS. 1095 00:46:26,640 --> 00:46:30,920 >>AND MAYBE I COULD ADD 1096 00:46:30,920 --> 00:46:31,640 ACROSS INSTITUTES, ALSO. 1097 00:46:31,640 --> 00:46:34,800 THERE IS A LOT OF COORDINATED 1098 00:46:34,800 --> 00:46:36,520 EFFORT IN OUR PROGRAMS IN 1099 00:46:36,520 --> 00:46:37,880 OTHER INSTITUTES AND THEN 1100 00:46:37,880 --> 00:46:40,600 THERE IS VERY STRICT RECEIPT 1101 00:46:40,600 --> 00:46:41,960 AND REFERRAL GUIDELINES AND 1102 00:46:41,960 --> 00:46:43,920 THE OVERLAP BETWEEN INSTITUTES 1103 00:46:43,920 --> 00:46:46,200 THAT GUIDE WHERE PARTICULAR 1104 00:46:46,200 --> 00:46:48,840 AREAS OF SCIENCE ARE MOST 1105 00:46:48,840 --> 00:46:50,800 APPROPRIATELY, YOU KNOW, PUT 1106 00:46:50,800 --> 00:46:53,520 INTO THAT PARTICULAR 1107 00:46:53,520 --> 00:46:56,600 INSTITUTE, EVEN THOUGH LIKE 1108 00:46:56,600 --> 00:46:59,400 Dr. HODES MENTIONED, THE 1109 00:46:59,400 --> 00:47:01,360 PROGRAM FOR ALZHEIMER'S 1110 00:47:01,360 --> 00:47:04,520 DISEASE SUPPLEMENTS TO 1111 00:47:04,520 --> 00:47:05,800 NONALZHEIMER'S DISEASE GRANTS 1112 00:47:05,800 --> 00:47:07,200 THROUGHOUT I THINK 21 OTHER 1113 00:47:07,200 --> 00:47:10,160 INSTITUTES, ALL OF THAT MONEY 1114 00:47:10,160 --> 00:47:13,120 IS COMING FROM US TO THOSE AND 1115 00:47:13,120 --> 00:47:14,280 MOVING FURTHER ALONG THE FIELD 1116 00:47:14,280 --> 00:47:16,320 BUT THAT IS AN EXPANSION IN 1117 00:47:16,320 --> 00:47:17,960 THE FIELD ABOUT ALZHEIMER'S 1118 00:47:17,960 --> 00:47:19,760 DISEASE AND THEN THAT BECOMES 1119 00:47:19,760 --> 00:47:22,960 PART OF THE PORTFOLIOS IN 1120 00:47:22,960 --> 00:47:24,560 THOSE INTEREST TOOT ALSO BUT 1121 00:47:24,560 --> 00:47:26,760 IT IS VERY STRICT IN, YOU 1122 00:47:26,760 --> 00:47:29,040 KNOW, THAT AREA OF RESEARCH 1123 00:47:29,040 --> 00:47:31,800 DOES GO TO THAT INSTITUTE AND 1124 00:47:31,800 --> 00:47:34,400 THEN THEY MONITOR EACH OF 1125 00:47:34,400 --> 00:47:35,400 THOSE PORTFOLIOS ENSURING 1126 00:47:35,400 --> 00:47:41,640 THERE IS NOT OVERLAP BETWEEN 1127 00:47:41,640 --> 00:47:44,320 THE INSTITUTES. 1128 00:47:44,320 --> 00:47:46,840 >>AND AGAIN I WOULD EMPHASIZE 1129 00:47:46,840 --> 00:47:48,720 THE IMPORTANT COLLABORATION 1130 00:47:48,720 --> 00:47:50,320 ACROSS NIH, WHAT INSTITUTE MAY 1131 00:47:50,320 --> 00:47:51,840 HAVE A PRIMARY ROLE, THERE IS 1132 00:47:51,840 --> 00:47:55,040 A VERY ACTIVE AND PRODUCTIVE 1133 00:47:55,040 --> 00:47:57,160 COLLABORATION ACROSS THE 1134 00:47:57,160 --> 00:48:01,800 INSTITUTE THAT IS A COFUNDING 1135 00:48:01,800 --> 00:48:07,800 THAT IS EVIDENT IN MANY AREAS, 1136 00:48:07,800 --> 00:48:09,480 LONGITUDINAL STUDIES IMPORTANT 1137 00:48:09,480 --> 00:48:12,240 IN LEVERAGING FUNDING AT NIH 1138 00:48:12,240 --> 00:48:13,480 AND COLLABORATION IS A VERY 1139 00:48:13,480 --> 00:48:19,440 IMPORTANT PART OF WHAT WE ARE 1140 00:48:19,440 --> 00:48:19,880 DOING AS WELL. 1141 00:48:19,880 --> 00:48:29,840 >>I DON'T HAVE A QUESTION, I 1142 00:48:29,840 --> 00:48:30,760 HAVE A COMMENT. 1143 00:48:30,760 --> 00:48:32,040 EVERYBODY IS LIKE -- 1144 00:48:32,040 --> 00:48:32,520 [INDISCERNIBLE] 1145 00:48:32,520 --> 00:48:37,800 THERE HAS BEEN A LOTT OF 1146 00:48:37,800 --> 00:48:43,240 DISCUSSION IF DIVERSITY AT NIH 1147 00:48:43,240 --> 00:48:44,440 AND VERY IMPORTANT AS WE CAN 1148 00:48:44,440 --> 00:48:46,120 SEE IN THIS ROOM. 1149 00:48:46,120 --> 00:48:48,000 I WOULD LIKE TO SUGGEST TO 1150 00:48:48,000 --> 00:48:51,480 MAYBE EXTEND IT A LITTLE BIT 1151 00:48:51,480 --> 00:48:52,560 TO INCLUDE COLLEGE LEVELS. 1152 00:48:52,560 --> 00:48:58,400 IN THE TRUE SENSE WE THINK OF 1153 00:48:58,400 --> 00:48:58,960 DIVERSITY -- 1154 00:48:58,960 --> 00:48:59,440 [INDISCERNIBLE] 1155 00:48:59,440 --> 00:49:01,840 BUT IF YOU GIVE AN OPPORTUNITY 1156 00:49:01,840 --> 00:49:03,240 TO FIRST ENRICH COLLEGE 1157 00:49:03,240 --> 00:49:05,880 RESIDENTS, YOU ARE CREATING A 1158 00:49:05,880 --> 00:49:06,280 ROLE MODEL. 1159 00:49:06,280 --> 00:49:08,440 I KNOW THIS FOR A FACT BECAUSE 1160 00:49:08,440 --> 00:49:15,640 I HAVE WORKED IN IN A 1161 00:49:15,640 --> 00:49:16,040 COMMUNITY. 1162 00:49:16,040 --> 00:49:19,440 CURRENTLY I KNOW SO MANY OF 1163 00:49:19,440 --> 00:49:22,800 THEM THE IF FIRST YEAR, ONES I 1164 00:49:22,800 --> 00:49:25,080 MENTORED, THEY HAD NO ROLE 1165 00:49:25,080 --> 00:49:26,680 MODEL, NOBODY THAT WENT TO 1166 00:49:26,680 --> 00:49:30,720 SCHOOL, NOBODY THAT WENT TO 1167 00:49:30,720 --> 00:49:33,080 COLLEGE IN BIOMEDICAL FIELD. 1168 00:49:33,080 --> 00:49:37,040 THEY HAVE ROLE MODELS IN THEIR 1169 00:49:37,040 --> 00:49:38,560 COMMUNITIES, IN THEIR FAMILIES 1170 00:49:38,560 --> 00:49:38,960 AND -- 1171 00:49:38,960 --> 00:49:39,440 [INDISCERNIBLE] 1172 00:49:39,440 --> 00:49:40,880 AND I THINK IT IS JUST A 1173 00:49:40,880 --> 00:49:44,600 THOUGHT BUT I HEAR A LOT OF 1174 00:49:44,600 --> 00:49:46,520 TALK ABOUT DIVERSITY, I NEVER 1175 00:49:46,520 --> 00:49:50,720 HEAR ABOUT SOMETHING LIKE THAT 1176 00:49:50,720 --> 00:49:52,200 THAT PROBABLY SHOULD BE A PART 1177 00:49:52,200 --> 00:49:58,800 OF THAT CONVERSATION. 1178 00:49:58,800 --> 00:50:00,560 THANK YOU. 1179 00:50:00,560 --> 00:50:01,960 >>YOU EXPECT SOME SWAEPBGS 1180 00:50:01,960 --> 00:50:04,320 OVERLAP BUT NOT IDENTITY IN 1181 00:50:04,320 --> 00:50:06,640 THE GENERAL CRITERIA AROUND 1182 00:50:06,640 --> 00:50:10,080 SOCIOECONOMIC STATUS BUT IT IS 1183 00:50:10,080 --> 00:50:12,000 AN IMPORTANT POINT TO ADDRESS. 1184 00:50:12,000 --> 00:50:14,760 AND WITH YOUR PERSPECTIVE 1185 00:50:14,760 --> 00:50:15,600 YEARS INCLUDING AS UNIVERSITY 1186 00:50:15,600 --> 00:50:17,800 PRESIDENT, YOU WANT TO COMMENT 1187 00:50:17,800 --> 00:50:18,600 ON THIS? 1188 00:50:18,600 --> 00:50:20,600 >>YES, IT IS ACTUALLY AN 1189 00:50:20,600 --> 00:50:21,600 EXCELLENT POINT. 1190 00:50:21,600 --> 00:50:23,200 TYPICALLY THESE DAYS WHEN YOU 1191 00:50:23,200 --> 00:50:25,280 TALK ABOUT DIVERSITY AND I 1192 00:50:25,280 --> 00:50:29,560 GUESS AS A PHYSICIAN AND MY 1193 00:50:29,560 --> 00:50:34,120 VIEW, WE DO TALK ABOUT THE 1194 00:50:34,120 --> 00:50:36,240 FIRST GENERATION AND THE 1195 00:50:36,240 --> 00:50:36,600 PIPELINE. 1196 00:50:36,600 --> 00:50:38,120 THAT IS ONE DIMENSION THAT YOU 1197 00:50:38,120 --> 00:50:40,480 CAN ACTUALLY TARGET AND IT 1198 00:50:40,480 --> 00:50:48,360 DOES HAVE THOSE LIKE 1199 00:50:48,360 --> 00:50:51,720 DOWNSTREAM EFFECTS THAT CAN 1200 00:50:51,720 --> 00:50:53,880 IMPACT THEIR FAMILY, THEIR 1201 00:50:53,880 --> 00:50:55,040 COMMUNITY AND THERE ARE OTHER 1202 00:50:55,040 --> 00:51:01,240 PIECES OF IT BUT IT IS ANOTHER 1203 00:51:01,240 --> 00:51:02,880 PIECE OF THE FACTORS. 1204 00:51:02,880 --> 00:51:05,720 WE HAVE GOT TEN AWAY FROM 1205 00:51:05,720 --> 00:51:08,040 DIVERSITY IN UNIVERSITIES AND 1206 00:51:08,040 --> 00:51:09,840 SAY WELL IT IS 15 PERCENT 1207 00:51:09,840 --> 00:51:10,760 HERE, 20 PERCENT THAT AND I 1208 00:51:10,760 --> 00:51:12,720 BET YOU WITH SOME OF THE 1209 00:51:12,720 --> 00:51:14,840 UNIVERSITY HIRES YOU HAVE, YOU 1210 00:51:14,840 --> 00:51:17,480 HAVE THE ONES THAT NEVER GET 1211 00:51:17,480 --> 00:51:17,960 HIGHLIGHTED. 1212 00:51:17,960 --> 00:51:21,160 WHEN WE THINK OF IT AS THE 1213 00:51:21,160 --> 00:51:22,480 COLLEGE LEVEL OF STUDENTS IN 1214 00:51:22,480 --> 00:51:24,400 THE PIPELINE, THAT IS ONE OF 1215 00:51:24,400 --> 00:51:25,680 THE CRITICAL PIECES BECAUSE 1216 00:51:25,680 --> 00:51:28,720 THEY FALL OUT OF PIPELINE 1217 00:51:28,720 --> 00:51:37,680 OFTEN BECAUSE THEY DON'T HAVE 1218 00:51:37,680 --> 00:51:39,240 THE FINANCIAL SUPPORT OR 1219 00:51:39,240 --> 00:51:41,400 MENTOR AND THAT COULD BE A 1220 00:51:41,400 --> 00:51:43,720 CHARACTERISTIC THAT COULD HELP 1221 00:51:43,720 --> 00:51:46,880 BROADEN DIVERSITY IN GENERAL. 1222 00:51:46,880 --> 00:51:49,840 >>OTHER QUESTIONS? 1223 00:51:49,840 --> 00:51:50,720 YEAH. 1224 00:51:50,720 --> 00:51:51,480 OKAY, THANK YOU. 1225 00:51:51,480 --> 00:51:54,160 >>YOU KNOW ONE OF THE AREAS 1226 00:51:54,160 --> 00:51:56,800 THAT WE ARE HEARING A LOT 1227 00:51:56,800 --> 00:51:58,080 ABOUT IS ARTIFICIAL 1228 00:51:58,080 --> 00:51:59,120 INTELLIGENCE AND MACHINE 1229 00:51:59,120 --> 00:52:04,000 LEARNING AND ITS APPLICATIONS 1230 00:52:04,000 --> 00:52:05,720 TO BIOMEDICAL SCIENCE. 1231 00:52:05,720 --> 00:52:08,680 ALL ARE OPPOSITION OF COURSE 1232 00:52:08,680 --> 00:52:10,880 AND THERE ARE SO MANY LEADING 1233 00:52:10,880 --> 00:52:12,160 SCIENTISTS IN JOURNALS AND 1234 00:52:12,160 --> 00:52:13,680 OTHER AREAS TALKING ABOUT THE 1235 00:52:13,680 --> 00:52:16,960 BENEFITS THAT WILL COME OUT OF 1236 00:52:16,960 --> 00:52:21,080 IT BUT ALSO A COMPLEX ISSUE 1237 00:52:21,080 --> 00:52:21,960 OF -- 1238 00:52:21,960 --> 00:52:22,440 [INDISCERNIBLE] 1239 00:52:22,440 --> 00:52:24,200 GIVEN THE DECADES OF RESEARCH 1240 00:52:24,200 --> 00:52:26,560 THAT NIA HAS DONE AND CREATED 1241 00:52:26,560 --> 00:52:35,480 HUGE DATA SETS OF ALL KINDS 1242 00:52:35,480 --> 00:52:38,040 AND BY DEPOSITORIES, MONTHS OF 1243 00:52:38,040 --> 00:52:39,440 STUDIES, I WONDER FOR IT IS 1244 00:52:39,440 --> 00:52:41,480 TIME FOR US TO THINK ABOUT A 1245 00:52:41,480 --> 00:52:47,360 COALITION TO CREATE A CENTRAL 1246 00:52:47,360 --> 00:52:49,120 RESOURCE AT NIA ON AI 1247 00:52:49,120 --> 00:52:51,200 ADDRESSING THE RISKS AND 1248 00:52:51,200 --> 00:52:52,520 ADVANTAGES LINKED WITH IT AND 1249 00:52:52,520 --> 00:52:55,000 THAT COULD BE PROVIDED AS A 1250 00:52:55,000 --> 00:52:57,200 SERVICE IN SOME WAYS TO THE 1251 00:52:57,200 --> 00:53:00,800 INVESTIGATORS WHO MAY NOT HAVE 1252 00:53:00,800 --> 00:53:05,000 RESOURCES OR A CHANCE TO 1253 00:53:05,000 --> 00:53:07,280 UTILIZE THE AMAZING 1254 00:53:07,280 --> 00:53:10,920 CONTRIBUTIONS IN ARTIFICIAL 1255 00:53:10,920 --> 00:53:11,800 INTELLIGENCE -- 1256 00:53:11,800 --> 00:53:12,240 [INDISCERNIBLE] 1257 00:53:12,240 --> 00:53:13,880 AND YOU NAME IT. 1258 00:53:13,880 --> 00:53:15,880 SO I WONDER IF ANY THOUGHT HAS 1259 00:53:15,880 --> 00:53:19,520 BEEN GIVEN IN THAT AREA OF 1260 00:53:19,520 --> 00:53:23,520 CREATING A CENTRAL DATA SOURCE 1261 00:53:23,520 --> 00:53:24,080 FOR NIA SCIENTISTS? 1262 00:53:24,080 --> 00:53:25,960 >> THANK YOU FOR THAT 1263 00:53:25,960 --> 00:53:26,920 QUESTION, VERY IMPORTANT. 1264 00:53:26,920 --> 00:53:29,160 AT THE NIH AND VERY MUCH AT 1265 00:53:29,160 --> 00:53:31,560 THE NIA LEVEL, WE HAVE ACTIVE 1266 00:53:31,560 --> 00:53:33,160 WORK GROUPS THAT TRANSCEND, 1267 00:53:33,160 --> 00:53:35,960 ALL OF OUR POSITIONS, 1268 00:53:35,960 --> 00:53:39,600 INTRAMURAL AND EXTRAMURAL 1269 00:53:39,600 --> 00:53:41,400 AROUND AI AND LOOKING AT THESE 1270 00:53:41,400 --> 00:53:41,840 POLICIES. 1271 00:53:41,840 --> 00:53:44,000 I DON'T KNOW YET IF WE ARE AT 1272 00:53:44,000 --> 00:53:48,960 THE POINT OF YOUR VERY 1273 00:53:48,960 --> 00:53:49,720 INTERESTING SUGGESTION, 1274 00:53:49,720 --> 00:53:51,360 TRANSPORTING IT TO A RESEARCH 1275 00:53:51,360 --> 00:53:54,520 CENTER BUT SOMETHING TO LOOK 1276 00:53:54,520 --> 00:53:57,080 AT AND CONSIDER AND A FAIR 1277 00:53:57,080 --> 00:53:58,920 POINT, TO THINK WHERE WE ARE 1278 00:53:58,920 --> 00:53:59,640 AND APPROPRIATE LEVEL, IF 1279 00:53:59,640 --> 00:54:02,720 THERE IS A ROLE FOR ACTUALLY 1280 00:54:02,720 --> 00:54:06,120 FUNDING OR SUPPORTING SOMEHOW 1281 00:54:06,120 --> 00:54:09,720 A CENTRAL RESOURCE FOR THIS. 1282 00:54:09,720 --> 00:54:11,680 >> THOSE CENTERS COULD BE 1283 00:54:11,680 --> 00:54:13,880 CREATED AT SOME INSTITUTIONS 1284 00:54:13,880 --> 00:54:15,720 AND NIA COULD SUPPORT IT, 1285 00:54:15,720 --> 00:54:16,520 EITHER WAY BUT THIS IS 1286 00:54:16,520 --> 00:54:18,160 SOMETHING THAT COULD BE VERY 1287 00:54:18,160 --> 00:54:19,920 USEFUL FOR THE FIELD. 1288 00:54:19,920 --> 00:54:21,320 >>YEAH, HEARING THIS, MAYBE A 1289 00:54:21,320 --> 00:54:23,400 TOPIC OF INTEREST IN ONE OF 1290 00:54:23,400 --> 00:54:24,440 OUR FUTURE COUNCIL MEETINGS 1291 00:54:24,440 --> 00:54:26,840 THAT WE COULD HAVE A REPORT 1292 00:54:26,840 --> 00:54:28,800 BACK FROM THE CORE GROUP AT 1293 00:54:28,800 --> 00:54:31,120 NIA THAT ARE DEALING WITH IT 1294 00:54:31,120 --> 00:54:36,400 AND YOU COULD OFFER YOUR 1295 00:54:36,400 --> 00:54:37,640 FURTHER INPUT. 1296 00:54:37,640 --> 00:54:40,280 >>ALL RIGHT, ANY LAST 1297 00:54:40,280 --> 00:54:40,640 QUESTIONS? 1298 00:54:40,640 --> 00:54:47,120 ALL RIGHT, THANK YOU VERY MUCH 1299 00:54:47,120 --> 00:54:48,960 FOR THOSE DISCUSSIONS AND 1300 00:54:48,960 --> 00:54:51,040 THANK YOU Dr. HODES FOR YOUR 1301 00:54:51,040 --> 00:54:51,720 DIRECTOR'S REPORT. 1302 00:54:51,720 --> 00:54:53,680 WE WILL MOVE ON. 1303 00:54:53,680 --> 00:54:55,200 THE NEXT AGENDA ITEM IS THE 1304 00:54:55,200 --> 00:55:01,240 REPORT ON THE TASK FORCE ON 1305 00:55:01,240 --> 00:55:01,920 THE AGING RESEARCH. 1306 00:55:01,920 --> 00:55:12,280 THE CHAIRS OF THIS 1307 00:55:15,600 --> 00:55:17,760 SUBCOMMITTEE, Dr. JENNIFER 1308 00:55:17,760 --> 00:55:20,160 MANLY AND Dr. CRUZ. 1309 00:55:20,160 --> 00:55:22,760 Dr. CRUZ WILL START US OFF. 1310 00:55:22,760 --> 00:55:25,640 >>GOOD MORNING AGAIN. 1311 00:55:25,640 --> 00:55:26,920 AFTER THE HEALTHY RESEARCH 1312 00:55:26,920 --> 00:55:28,000 SECTION YESTERDAY AND STARTING 1313 00:55:28,000 --> 00:55:30,520 WITH THAT, WE HAD THREE GUEST 1314 00:55:30,520 --> 00:55:31,280 SPEAKERS. 1315 00:55:31,280 --> 00:55:33,320 WE STARTED WITH Dr. ROBERT 1316 00:55:33,320 --> 00:55:41,560 GREEN WHO THEN MOVED ON TO 1317 00:55:41,560 --> 00:55:45,440 Dr. SIMPSON'S VIDEO AND THE 1318 00:55:45,440 --> 00:55:47,760 LAST PERSON WAS MISS JOY 1319 00:55:47,760 --> 00:55:48,520 TOLLIVER. 1320 00:55:48,520 --> 00:55:52,160 SO JUST SOME QUICK HIGHLIGHTS 1321 00:55:52,160 --> 00:55:54,200 ON Dr. ROBIN GREEN'S 1322 00:55:54,200 --> 00:55:56,680 PRESENTATION, HER FOCUS WAS 1323 00:55:56,680 --> 00:55:58,840 STRATEGIES FOR EFFECTIVELY 1324 00:55:58,840 --> 00:56:01,240 ENGAGING WOMEN OF COLOR INTO 1325 00:56:01,240 --> 00:56:02,280 CLINICAL TRIALS. 1326 00:56:02,280 --> 00:56:04,680 AND SO Dr. GREEN'S COMMENTS 1327 00:56:04,680 --> 00:56:06,600 WERE PRIMARILY BASED ON THIS 1328 00:56:06,600 --> 00:56:13,040 STUDY WHICH IS A MAJOR 1329 00:56:13,040 --> 00:56:14,000 PERSPECTIVE LONGITUDINAL STUDY 1330 00:56:14,000 --> 00:56:16,840 ON THE NATIONAL HISTORY OF 1331 00:56:16,840 --> 00:56:18,760 MENOPAUSE AND DECLINING 1332 00:56:18,760 --> 00:56:19,160 FUNCTION. 1333 00:56:19,160 --> 00:56:20,520 THE STUDY INVOLVES SEVEN 1334 00:56:20,520 --> 00:56:22,680 CLINICAL SITES ACROSS THE 1335 00:56:22,680 --> 00:56:26,000 NATION, RECRUITING WOMEN FROM 1336 00:56:26,000 --> 00:56:29,840 DIVERSE, ETHNIC AND RACIAL 1337 00:56:29,840 --> 00:56:30,920 GROUPS, SENATOR SOCIOECONOMIC 1338 00:56:30,920 --> 00:56:38,960 STATUS, REGIONS AND REGIONS OF 1339 00:56:38,960 --> 00:56:39,720 THE COUNTRY.. 1340 00:56:39,720 --> 00:56:42,120 THIS OF COURSE IS 1341 00:56:42,120 --> 00:56:44,520 REPRESENTATIVE OF 1342 00:56:44,520 --> 00:56:45,920 AFRICAN-AMERICAN WOMEN, 1343 00:56:45,920 --> 00:56:48,160 CHINESE, JAPANESE, HISPANIC 1344 00:56:48,160 --> 00:56:50,920 AND CAUCASIAN WOMEN. 1345 00:56:50,920 --> 00:56:55,320 IT HAS ENROLLED OVER 3302 1346 00:56:55,320 --> 00:56:57,480 WOMEN AT SEVEN SITES. 1347 00:56:57,480 --> 00:57:01,240 AND HER TALK WAS LOOKING AT 1348 00:57:01,240 --> 00:57:04,640 THE EFFECTIVE STRATEGIES BASED 1349 00:57:04,640 --> 00:57:09,480 ON HER WORK. 1350 00:57:09,480 --> 00:57:11,080 SHE HIGHLIGHTED THE 1351 00:57:11,080 --> 00:57:12,440 RECRUITMENT STRATEGY THAT SHE 1352 00:57:12,440 --> 00:57:16,760 THINKS HAS BEEN USEFUL IN 1353 00:57:16,760 --> 00:57:18,360 REACHING AND ENGAGING DIVERSE 1354 00:57:18,360 --> 00:57:20,240 POPULATIONS SO SHE TALKED 1355 00:57:20,240 --> 00:57:25,600 ABOUT, YOU KNOW, USING CENSUS, 1356 00:57:25,600 --> 00:57:27,400 UTILITY RECORDS, VOTER 1357 00:57:27,400 --> 00:57:28,160 REGISTRATION, TELEPHONE 1358 00:57:28,160 --> 00:57:31,400 DIRECTORY AND ALSO RACIAL AND 1359 00:57:31,400 --> 00:57:33,720 ETHIC ORGANIZATION MEMBERSHIP 1360 00:57:33,720 --> 00:57:36,120 MECHANISMS OF ENGAGING, 1361 00:57:36,120 --> 00:57:36,840 CONNECTING, MOBILIZING 1362 00:57:36,840 --> 00:57:44,440 POTENTIAL PARTICIPANTS FOR 1363 00:57:44,440 --> 00:57:45,760 THIS STUDY. 1364 00:57:45,760 --> 00:57:46,920 SHE TALKED ABOUT THE 1365 00:57:46,920 --> 00:57:50,560 IMPORTANCE OF USING MULTIPLE 1366 00:57:50,560 --> 00:57:52,320 RECRUIT RECRUITMENT STRATEGIES 1367 00:57:52,320 --> 00:57:54,520 SUCH AS SNOWBALLING WHERE 1368 00:57:54,520 --> 00:57:56,160 RECUTES WERE ASKED TO 1369 00:57:56,160 --> 00:57:57,000 RECOMMEND OTHERS. 1370 00:57:57,000 --> 00:57:58,920 Dr. GREEN ALSO EMPHASIZED 1371 00:57:58,920 --> 00:58:01,800 THE IMPORTANCE OF THE SILO 1372 00:58:01,800 --> 00:58:05,360 PIECE IN TRANSPORTATION TO 1373 00:58:05,360 --> 00:58:07,360 EFFECTIVELY ENGAGE 1374 00:58:07,360 --> 00:58:08,240 PARTICIPANTS, PROVIDING 1375 00:58:08,240 --> 00:58:09,320 TRANSPORTATION FOR EXAMPLE IS 1376 00:58:09,320 --> 00:58:13,640 IMPORTANT PARTICULARLY IN 1377 00:58:13,640 --> 00:58:16,360 DIVERSE POPULATIONS. 1378 00:58:16,360 --> 00:58:18,880 SHE ALSO ADDRESSED PORTIONS OF 1379 00:58:18,880 --> 00:58:20,840 BEING INTENTIONAL ABOUT 1380 00:58:20,840 --> 00:58:23,440 FOCUSING ON RESEARCH ON HEALTH 1381 00:58:23,440 --> 00:58:26,400 INTERESTS TO THE POPULATION 1382 00:58:26,400 --> 00:58:28,120 BEING TARGETED. 1383 00:58:28,120 --> 00:58:30,280 WHEN CONDUCTING DISPARITY, 1384 00:58:30,280 --> 00:58:32,240 HIGHLIGHTED BEING CULTURALLY 1385 00:58:32,240 --> 00:58:33,120 COMPETENT. 1386 00:58:33,120 --> 00:58:36,360 AN EXAMPLE, SUCH AS ALLOWING 1387 00:58:36,360 --> 00:58:40,400 FAMILY MEMBERS TO ACCOMPANY 1388 00:58:40,400 --> 00:58:41,680 PARTICIPANTS WITH ACCESS IN 1389 00:58:41,680 --> 00:58:45,400 THE CLINE AND ACKNOWLEDGE THE 1390 00:58:45,400 --> 00:58:48,640 IMPORTANCE OF FAMILY IN THE 1391 00:58:48,640 --> 00:58:49,640 PROCESS. 1392 00:58:49,640 --> 00:58:54,880 PROVIDING FLEXIBLE SCHEDULING 1393 00:58:54,880 --> 00:58:57,120 AND REMUNERATION AND SHE 1394 00:58:57,120 --> 00:58:58,600 THOUGHT THAT WOULD BE 1395 00:58:58,600 --> 00:58:59,720 IMPORTANT. 1396 00:58:59,720 --> 00:59:02,400 AND THEN HIGHLIGHTED 1397 00:59:02,400 --> 00:59:07,080 TRANSFORMATION OF LITERACY -- 1398 00:59:07,080 --> 00:59:07,760 TRANSLATION AND LITERACY. 1399 00:59:07,760 --> 00:59:12,040 IN THIS ONE CLINIC, THEY HAVE 1400 00:59:12,040 --> 00:59:20,600 TRANSLATED ALL THE MATERIAL. 1401 00:59:20,600 --> 00:59:23,240 AND SHE MENTIONED THE SITE 1402 00:59:23,240 --> 00:59:25,720 STAFF COMING FROM COPIOUS 1403 00:59:25,720 --> 00:59:26,760 RACIAL GROUPS, SPEAKING THE 1404 00:59:26,760 --> 00:59:28,400 LANGUAGES REPRESENTED IN THE 1405 00:59:28,400 --> 00:59:30,880 STUDY PARTICIPANTS AND ARE 1406 00:59:30,880 --> 00:59:34,280 KNOWLEDGEABLE OF CULTURAL 1407 00:59:34,280 --> 00:59:34,600 CUSTOMS. 1408 00:59:34,600 --> 00:59:36,160 SHE ALSO SPOKE ABOUT THE 1409 00:59:36,160 --> 00:59:37,640 IMPORTANCE OF TRANSPARENCY AND 1410 00:59:37,640 --> 00:59:40,960 MAKING CONTACT WITH STUDY 1411 00:59:40,960 --> 00:59:43,000 PARTICIPANTS INCLUDING 1412 00:59:43,000 --> 00:59:44,960 PROVIDING RESULTS FOR MANY 1413 00:59:44,960 --> 00:59:47,000 EDUCATORS OF WELLNESS AND 1414 00:59:47,000 --> 00:59:48,760 ALERT FOR INDICATORS OF 1415 00:59:48,760 --> 00:59:50,040 POTENTIAL UNDERLYING DISEASE. 1416 00:59:50,040 --> 00:59:53,840 AND SHE ALSO URGED RESEARCHERS 1417 00:59:53,840 --> 00:59:57,640 TO LOOK THROUGH AN AGING LIST, 1418 00:59:57,640 --> 00:59:59,560 THAT PARTICIPANTS MAY NEED 1419 00:59:59,560 --> 01:00:02,920 MORE ASSISTANCE. 1420 01:00:02,920 --> 01:00:05,280 LARGER FONT, FOR EXAMPLE, FOR 1421 01:00:05,280 --> 01:00:07,400 READING THE MATERIAL. 1422 01:00:07,400 --> 01:00:13,680 SO Dr. GREEN SUGGESTED A 1423 01:00:13,680 --> 01:00:15,640 DIVERSE STUDY FOR THE DIVERSE. 1424 01:00:15,640 --> 01:00:26,120 AND THEN NEXT WE HAD Dr. 1425 01:00:29,640 --> 01:00:33,640 JOHNSON WHO TALKED ABOUT 1426 01:00:33,640 --> 01:00:36,720 OUTREACH THOSE AFFECTED BY 1427 01:00:36,720 --> 01:00:42,760 COVID-19 PANDEMIC AND VACCINE 1428 01:00:42,760 --> 01:00:49,080 AND THERAPEUTIC TRIALS. 1429 01:00:49,080 --> 01:00:51,000 Dr. MASON INDICATED THE 1430 01:00:51,000 --> 01:00:52,480 CRITICAL TOOLS IN HEALTH 1431 01:00:52,480 --> 01:00:54,800 DISPARITIES AND ARE WHEN 1432 01:00:54,800 --> 01:00:55,960 CONDUCTED CORRECTLY, RESEARCH 1433 01:00:55,960 --> 01:00:58,320 PROCESS FUNDING AND POTENTIAL 1434 01:00:58,320 --> 01:01:00,240 INTERVENTIONS TO ADDRESS 1435 01:01:00,240 --> 01:01:01,280 HEALTH DISPARITIES RESONATES 1436 01:01:01,280 --> 01:01:11,840 AND BENEFITS THE COMMUNITY. 1437 01:01:11,840 --> 01:01:17,040 IN THE CASE OF THE FOCUS, THEY 1438 01:01:17,040 --> 01:01:20,720 ARE LOOKING AT NATIVE 1439 01:01:20,720 --> 01:01:23,120 AMERICAN, ALASKA NATIVE, ASIAN 1440 01:01:23,120 --> 01:01:24,640 HAWAIIANS AND PACIFIC 1441 01:01:24,640 --> 01:01:25,120 ISLANDERS. 1442 01:01:25,120 --> 01:01:29,320 THE OBJECTIVES OF THE APPEAL 1443 01:01:29,320 --> 01:01:32,960 ARE, ONE, TO CONDUCT COMMUNITY 1444 01:01:32,960 --> 01:01:35,040 RESEARCH AND FOCUSED AWARENESS 1445 01:01:35,040 --> 01:01:37,520 AND EDUCATION TO ADDRESS 1446 01:01:37,520 --> 01:01:38,880 WIDESPREAD MISINFORMATION AND 1447 01:01:38,880 --> 01:01:41,400 DISTRUST WITH REGARD TO 1448 01:01:41,400 --> 01:01:43,920 COVID-19 AND PROVIDE EVIDENCE 1449 01:01:43,920 --> 01:01:53,840 BASED RESPONSE TO THE DISEASE. 1450 01:01:53,840 --> 01:01:55,440 SECOND, FACILITATED 1451 01:01:55,440 --> 01:01:58,920 INCLUSION -- 1452 01:01:58,920 --> 01:01:59,840 [INDISCERNIBLE] 1453 01:01:59,840 --> 01:02:00,480 AND THERAPEUTICS. 1454 01:02:00,480 --> 01:02:05,320 SOME OF THE ACTIVITIES DONE BY 1455 01:02:05,320 --> 01:02:08,600 THE TEAMS INCLUDE ESTABLISHED 1456 01:02:08,600 --> 01:02:12,240 REPRESENTATION OF COMMUNITIES, 1457 01:02:12,240 --> 01:02:13,480 ESTABLISHED REPRESENTATION, 1458 01:02:13,480 --> 01:02:18,440 INCREASED TRUST IN SCIENCE AND 1459 01:02:18,440 --> 01:02:19,280 INTERVENTION. 1460 01:02:19,280 --> 01:02:21,320 THE DOCTOR TALKED ABOUT 1461 01:02:21,320 --> 01:02:23,560 LESSONS LEARNED FROM THIS 1462 01:02:23,560 --> 01:02:24,160 EXPERIENCE. 1463 01:02:24,160 --> 01:02:32,120 FIRST THAT LEADERSHIP HAS A 1464 01:02:32,120 --> 01:02:33,000 DIFFERENT LENGTH. 1465 01:02:33,000 --> 01:02:34,600 LOCAL GOVERNMENT OFFICIALS, 1466 01:02:34,600 --> 01:02:36,240 FAITH LEADERS ARE INS. 1467 01:02:36,240 --> 01:02:37,640 AL TO REACH A COMMUNITY IN 1468 01:02:37,640 --> 01:02:41,560 EFFECTIVE WAYS SO WE NEED TO 1469 01:02:41,560 --> 01:02:43,280 WORK WITH THEM. 1470 01:02:43,280 --> 01:02:46,240 COLLABORATION AND CULTIVATION 1471 01:02:46,240 --> 01:02:47,360 WITH COMMUNITY PARTNERS. 1472 01:02:47,360 --> 01:02:49,000 COMMUNITY INCREASES THE 1473 01:02:49,000 --> 01:02:50,360 EFFECTIVENESS OF ENGAGEMENT, 1474 01:02:50,360 --> 01:02:53,280 WORKING IN COLLABORATION WITH 1475 01:02:53,280 --> 01:02:57,080 LOCAL COMMUNITY ORGANIZATIONS. 1476 01:02:57,080 --> 01:02:59,360 RACE, ETHNIC DATA ARE CRITICAL 1477 01:02:59,360 --> 01:03:02,800 TO THE COVERAGE OF DISPARITIES 1478 01:03:02,800 --> 01:03:04,200 IN EXISTING DATA. 1479 01:03:04,200 --> 01:03:06,760 HAVING MULTIPLE LANGUAGES IS 1480 01:03:06,760 --> 01:03:10,280 CRITICAL TO THE COMMUNITY. 1481 01:03:10,280 --> 01:03:12,560 SPECIFIC DEMANDS FOR EXPERTISE 1482 01:03:12,560 --> 01:03:14,280 IN COMMUNITY ENGAGEMENT AND 1483 01:03:14,280 --> 01:03:15,000 RESEARCH. 1484 01:03:15,000 --> 01:03:18,880 AND THEN FINALLY WE HEARD FROM 1485 01:03:18,880 --> 01:03:22,320 MS. DORIS TOLLIVER AND SHE 1486 01:03:22,320 --> 01:03:29,640 HIGHLIGHTED THE NIH STARTUP 1487 01:03:29,640 --> 01:03:30,560 TALENT FOSTERING 1488 01:03:30,560 --> 01:03:32,160 ENTREPRENEURIAL WITH DIVERSITY 1489 01:03:32,160 --> 01:03:34,680 AND HIGHLIGHTED THE NIH SMALL 1490 01:03:34,680 --> 01:03:35,760 BUSINESS PROGRAM AND 1491 01:03:35,760 --> 01:03:39,080 INDICATING THAT IT PROVIDES 1492 01:03:39,080 --> 01:03:40,840 MORE THAN $140 MILLION IN 1493 01:03:40,840 --> 01:03:42,680 USING DEVELOPMENT GRANTS TO 1494 01:03:42,680 --> 01:03:45,320 SMALL BUSINESSES, THROUGH THE 1495 01:03:45,320 --> 01:03:48,440 SMALL BUSINESS INNOVATION 1496 01:03:48,440 --> 01:03:51,240 RESEARCH, FBI R AND SMALL 1497 01:03:51,240 --> 01:03:52,720 TRANSFERS PROGRAMS. 1498 01:03:52,720 --> 01:03:59,040 TO DEVELOP INNOVATION TO 1499 01:03:59,040 --> 01:04:00,520 ADDRESS INFO RELATED 1500 01:04:00,520 --> 01:04:00,920 CONDITIONS. 1501 01:04:00,920 --> 01:04:05,040 AND THE PROBLEMS ADDRESSES 1502 01:04:05,040 --> 01:04:07,560 HERE THROUGH THE EFFORTS AT 1503 01:04:07,560 --> 01:04:10,760 PERSISTENT LOW LEVELS OF NIH. 1504 01:04:10,760 --> 01:04:12,360 AND FOCUS ON WOMEN AND 1505 01:04:12,360 --> 01:04:14,000 MINORITIES IS VERY LOW SO 1506 01:04:14,000 --> 01:04:15,200 HOPEFULLY THROUGH THIS 1507 01:04:15,200 --> 01:04:17,200 PROGRAM, WE WILL MAKE A 1508 01:04:17,200 --> 01:04:21,880 DIFFERENCE IN THAT SPACE. 1509 01:04:21,880 --> 01:04:23,160 MS.TOLLIVER HIGHLIGHTED NIH'S 1510 01:04:23,160 --> 01:04:25,960 APPLICATIONS OF THE PROGRAM 1511 01:04:25,960 --> 01:04:31,640 AND PROGRAMS OFFERING NIH FBI 1512 01:04:31,640 --> 01:04:34,320 R LEVEL 1 APPLICATIONS 1513 01:04:34,320 --> 01:04:36,160 SUBMITTED BY UNDER REPRESENTED 1514 01:04:36,160 --> 01:04:38,160 SMALL BUSINESSES THAT ARE 1515 01:04:38,160 --> 01:04:41,200 COMPLIANT AND RESPONSIVE TO 1516 01:04:41,200 --> 01:04:42,080 THESE CRITERIA. 1517 01:04:42,080 --> 01:04:45,600 IT WAS ALSO INDICATED THAT NIH 1518 01:04:45,600 --> 01:04:49,120 HAS AS ITS GOAL TO FOSTER 1519 01:04:49,120 --> 01:04:53,040 DIVERSITY IN ITS RESEARCH, 1520 01:04:53,040 --> 01:04:53,920 INNOVATION AND 1521 01:04:53,920 --> 01:04:55,960 ENTREPRENEURSHIP AS WELL AS 1522 01:04:55,960 --> 01:05:01,680 GOALS TO INCREASE SDI R&D IR 1523 01:05:01,680 --> 01:05:03,800 TO EFFECT SMALL BUSINESSES AND 1524 01:05:03,800 --> 01:05:05,320 WOMEN-OWNED SMALL BUSINESSES. 1525 01:05:05,320 --> 01:05:11,920 THIS HAS THE POTENTIAL OF 1526 01:05:11,920 --> 01:05:14,080 PROVIDING STRATEGIC RESOURCES 1527 01:05:14,080 --> 01:05:16,920 TO ENTREPRENEURS WITH 1528 01:05:16,920 --> 01:05:21,000 INNOVATIVE IDEAS FOR RESEARCH 1529 01:05:21,000 --> 01:05:23,040 TECHNOLOGY FOR ALL PRODUCTS 1530 01:05:23,040 --> 01:05:25,440 THAT WILL FURTHER RESEARCH AND 1531 01:05:25,440 --> 01:05:27,160 DEMONSTRATION AND THE TALENT 1532 01:05:27,160 --> 01:05:30,680 TO ACCELERATE THEIR IDEAS. 1533 01:05:30,680 --> 01:05:32,080 MOVING FORWARD, THE 2023NIH 1534 01:05:32,080 --> 01:05:38,000 CHALLENGE WILL BE LAUNCHED -- 1535 01:05:38,000 --> 01:05:38,480 [INDISCERNIBLE] 1536 01:05:38,480 --> 01:05:41,280 >> A COUPLE OF POINTS. 1537 01:05:41,280 --> 01:05:50,240 ONE IS THE FIRST TWO TALKS 1538 01:05:50,240 --> 01:05:53,440 THAT SUMMARIZE VERY WELL JUST 1539 01:05:53,440 --> 01:05:57,440 NOW WERE REALLY ABOUT 1540 01:05:57,440 --> 01:05:58,240 INTENTIONA L INVESTMENTS IN 1541 01:05:58,240 --> 01:06:08,800 THE COMMUNITIES THAT YOU ARE 1542 01:06:12,160 --> 01:06:13,080 TRYING TO REACH. 1543 01:06:13,080 --> 01:06:14,680 AND HOW IMPORTANT TRUST, A 1544 01:06:14,680 --> 01:06:18,160 MUTUAL TRUST WAS IN ENGAGEING 1545 01:06:18,160 --> 01:06:21,640 INVOLVEMENT AND THEY WERE VERY 1546 01:06:21,640 --> 01:06:22,280 SUCCESSFUL, FOR EXAMPLE. 1547 01:06:22,280 --> 01:06:24,920 WE WANTED TO BRING THOSE TWO 1548 01:06:24,920 --> 01:06:26,840 TO COUNCIL IN PART BECAUSE, 1549 01:06:26,840 --> 01:06:30,760 YOU KNOW, AS WE DISCUSSED, 1550 01:06:30,760 --> 01:06:33,480 ALZHEIMER'S DISEASE AND 1551 01:06:33,480 --> 01:06:34,480 RELATED DEMENTIA RESEARCH IS 1552 01:06:34,480 --> 01:06:36,640 VERY MUCH AN EMPHASIS IN NIA 1553 01:06:36,640 --> 01:06:38,800 RIGHT NOW BUT HAVING A NUMBER 1554 01:06:38,800 --> 01:06:42,240 OF CHALLENGES IN RECRUITMENT 1555 01:06:42,240 --> 01:06:45,080 ACROSS DIFFERENT RACIAL AND 1556 01:06:45,080 --> 01:06:46,480 ETHNIC AND SOCIOECONOMIC 1557 01:06:46,480 --> 01:06:48,160 GROUPS, HAVING A LOT OF 1558 01:06:48,160 --> 01:06:49,680 TROUBLE IN CLINICAL TRIALS. 1559 01:06:49,680 --> 01:06:56,920 IN SOME CLINICAL TRIALS, YOU 1560 01:06:56,920 --> 01:06:58,400 KNOW, HAVING PARTICIPATION 1561 01:06:58,400 --> 01:07:01,480 FROM COMMUNITIES THAT FROM 1562 01:07:01,480 --> 01:07:04,200 DISPROPORTIONATELY AFFECTED BY 1563 01:07:04,200 --> 01:07:07,200 COGNITIVE IMPAIRMENT. 1564 01:07:07,200 --> 01:07:10,600 AND SO THESE SUCCESSFUL 1565 01:07:10,600 --> 01:07:12,280 EXAMPLES REALLY SHOWS THE TYPE 1566 01:07:12,280 --> 01:07:14,480 OF INVESTMENT THAT IS NEEDED 1567 01:07:14,480 --> 01:07:16,920 IN ORDER TO INCREASE 1568 01:07:16,920 --> 01:07:17,360 PARTICIPATION. 1569 01:07:17,360 --> 01:07:24,120 AND THEN I THINK WITH THE -- 1570 01:07:24,120 --> 01:07:28,520 THE STARTUP CHALLENGE, AGAIN, 1571 01:07:28,520 --> 01:07:30,120 REALLY BUILDING CAPACITY FOR 1572 01:07:30,120 --> 01:07:32,400 THE TYPE OF SCIENCE THAT IS 1573 01:07:32,400 --> 01:07:34,000 REALLY GOING TO MOVE IT 1574 01:07:34,000 --> 01:07:37,240 FORWARD IN A VERY RIGOROUS 1575 01:07:37,240 --> 01:07:40,080 WAY, THE INCLUSIVE -- AN 1576 01:07:40,080 --> 01:07:46,720 INCLUSIVE WORKFORCE AS WELL AS 1577 01:07:46,720 --> 01:07:48,760 AN INCLUSIVE PARTICIPATION, IS 1578 01:07:48,760 --> 01:07:53,760 YOU KNOW THE BASIS OF A 1579 01:07:53,760 --> 01:07:54,920 RIGOROUS SCIENCE AND 1580 01:07:54,920 --> 01:07:55,360 INNOVATION. 1581 01:07:55,360 --> 01:07:56,760 SO I THOUGHT THESE WERE 1582 01:07:56,760 --> 01:07:59,720 WONDERFUL EXAMPLES AND THANK 1583 01:07:59,720 --> 01:08:02,480 YOU FOR ALLOWING US TO TALK 1584 01:08:02,480 --> 01:08:02,800 TODAY. 1585 01:08:02,800 --> 01:08:04,320 >>THANK YOU VERY MUCH, 1586 01:08:04,320 --> 01:08:06,600 DOCTORS CRUZ AND MANLY FOR THE 1587 01:08:06,600 --> 01:08:09,240 OVERVIEW OF THE TASK FORCE 1588 01:08:09,240 --> 01:08:09,680 PRESENTATION. 1589 01:08:09,680 --> 01:08:10,680 ANY FURTHER COMMENTS OR 1590 01:08:10,680 --> 01:08:19,760 QUESTIONS FROM COUNCIL MEMBERS 1591 01:08:19,760 --> 01:08:20,880 ON THOSE PRESENTATIONS? 1592 01:08:20,880 --> 01:08:25,320 >>I ALMOST DUMPED MY WATER. 1593 01:08:25,320 --> 01:08:27,720 I THOUGHT THOSE WERE REALLY 1594 01:08:27,720 --> 01:08:29,920 WONDERFUL, SORT OF SUCCESSFUL 1595 01:08:29,920 --> 01:08:30,560 RECRUITMENT STRATEGIES SO I 1596 01:08:30,560 --> 01:08:32,640 THINK THIS WILL END UP BEING A 1597 01:08:32,640 --> 01:08:33,960 TWO-PART QUESTION. 1598 01:08:33,960 --> 01:08:37,040 THE FIRST IS HAS NIH ATTEMPTED 1599 01:08:37,040 --> 01:08:41,920 TO CAPTURE THIS IN A MORE 1600 01:08:41,920 --> 01:08:44,960 COMPREHENSIVE LOOK AT 1601 01:08:44,960 --> 01:08:45,640 RECRUITING RESEARCH ACROSS 1602 01:08:45,640 --> 01:08:49,960 PROJECTS AND IF NOT, IS THAT 1603 01:08:49,960 --> 01:08:56,280 SOMETHING NIH SHOULD BE 1604 01:08:56,280 --> 01:08:56,640 ASSESSING? 1605 01:08:56,640 --> 01:09:00,520 THE SECOND AND WHAT I THINK 1606 01:09:00,520 --> 01:09:06,760 ARE ADDITIONAL CHALLENGES FROM 1607 01:09:06,760 --> 01:09:09,400 NIARD, FAMILY FACTORED IN AND 1608 01:09:09,400 --> 01:09:11,000 THESE WERE REALLY SUCCESSFUL 1609 01:09:11,000 --> 01:09:12,000 PROGRAMS THAT PEOPLE IN 1610 01:09:12,000 --> 01:09:15,960 GENERAL COULD GET THERE ON 1611 01:09:15,960 --> 01:09:21,520 THEIR OWN TWO FEET WHEN 1612 01:09:21,520 --> 01:09:22,080 TRAVELING DOWNTOWN. 1613 01:09:22,080 --> 01:09:27,640 SO HOW COULD YOU PRIORITIZE 1614 01:09:27,640 --> 01:09:28,880 CAREGIVERS, UNLICK ME WHO 1615 01:09:28,880 --> 01:09:30,160 COULD SUPPORT MYSELF AND TAKE 1616 01:09:30,160 --> 01:09:32,280 CARE OF THE PEOPLE I AM TAKING 1617 01:09:32,280 --> 01:09:34,240 CARE OF VIA PHONE AND STILL DO 1618 01:09:34,240 --> 01:09:35,840 MY JOB, HOW ARE WE THINKING 1619 01:09:35,840 --> 01:09:39,360 ABOUT OR SHOULD WE BE THINKING 1620 01:09:39,360 --> 01:09:41,920 ABOUT CIRCULAR TO OUR HOURLY 1621 01:09:41,920 --> 01:09:47,240 WAGE WORKERS WHO DON'T HAVE 1622 01:09:47,240 --> 01:09:50,080 THE LUXURY HAD LUXURY THAT I 1623 01:09:50,080 --> 01:09:52,040 HAD TAKING CARE OF MOM THROUGH 1624 01:09:52,040 --> 01:09:55,800 A PERIOD OF TIME AND SHOULD WE 1625 01:09:55,800 --> 01:10:00,680 BE THINKING ABOUT THAT FOR THE 1626 01:10:00,680 --> 01:10:04,920 NEXT GENERATION OF 1627 01:10:04,920 --> 01:10:05,640 GERI-GENETICS? 1628 01:10:05,640 --> 01:10:06,760 >>JENIN, YOU WANT TO ADDRESS 1629 01:10:06,760 --> 01:10:08,160 THE SECOND QUESTION ON 1630 01:10:08,160 --> 01:10:10,560 CAREGIVERS FIRST AND THEN I 1631 01:10:10,560 --> 01:10:11,840 COULD PROBABLY CHIME IN 1632 01:10:11,840 --> 01:10:15,120 DETERMINING WHAT THE NIH 1633 01:10:15,120 --> 01:10:17,080 EFFORTS ARE GIVEN THE EXAMPLE. 1634 01:10:17,080 --> 01:10:18,600 >>WELL, I AM NOT GOING TO BE 1635 01:10:18,600 --> 01:10:21,120 ABLE TO SPEAK TO ALL CARE 1636 01:10:21,120 --> 01:10:27,720 GIVING RESEARCH SUPPORTED BY 1637 01:10:27,720 --> 01:10:29,320 NIA BUT SOME OF THE PROGRAM 1638 01:10:29,320 --> 01:10:31,440 STAFF MIGHT BE ABLE TO ADD TO 1639 01:10:31,440 --> 01:10:31,880 THIS. 1640 01:10:31,880 --> 01:10:35,200 I DO THINK WE ACTUALLY, YOU 1641 01:10:35,200 --> 01:10:38,280 KNOW, IN THIS ROOM YESTERDAY 1642 01:10:38,280 --> 01:10:42,320 WERE DISCUSSING, YOU KNOW SOME 1643 01:10:42,320 --> 01:10:46,560 POTENTIAL WAYS OF REACHING OUT 1644 01:10:46,560 --> 01:10:49,200 TO CAREGIVERS AND ENGAGING 1645 01:10:49,200 --> 01:10:51,640 CAREGIVERS WHERE THEY ARE IN 1646 01:10:51,640 --> 01:10:52,760 THEIR HOMES, REMOTELY. 1647 01:10:52,760 --> 01:10:54,480 AND I ACTUALLY THINK DUE TO 1648 01:10:54,480 --> 01:10:58,640 THE PANDEMIC, WE HAD SOME OP 1649 01:10:58,640 --> 01:11:00,440 OPPORTUNITIES TO BE CREEP 1650 01:11:00,440 --> 01:11:02,680 UNITIVE ABOUT THAT. 1651 01:11:02,680 --> 01:11:05,360 OVER THE PHONE OR YOU KNOW 1652 01:11:05,360 --> 01:11:06,160 PROVIDING -- I KNOW THERE ARE 1653 01:11:06,160 --> 01:11:08,360 A NUMBER OF STUDIES PROVIDING 1654 01:11:08,360 --> 01:11:10,200 PEOPLE WITH DEVICES AND 1655 01:11:10,200 --> 01:11:13,320 INTERNET ACCESS IN ORDER TO 1656 01:11:13,320 --> 01:11:16,680 INCREEPS THAT COMMUNICATION. 1657 01:11:16,680 --> 01:11:21,240 AND YOU KNOW ESSENTIALLY FOR 1658 01:11:21,240 --> 01:11:25,120 MOTHERS, THERE ARE TOOLAS THAT 1659 01:11:25,120 --> 01:11:29,440 ARE, YOU KNOW -- WHO ARE 1660 01:11:29,440 --> 01:11:31,480 GUIDING PEOPLE THROUGH THE 1661 01:11:31,480 --> 01:11:35,520 BIRTH PROCESS BUT FOR 1662 01:11:35,520 --> 01:11:37,880 CAREGIVERS, THERE COULD BE 1663 01:11:37,880 --> 01:11:38,680 ESSENTIALLY EQUIVALENT 1664 01:11:38,680 --> 01:11:40,720 LENGTHS, RIGHT, PEOPLE WHO ARE 1665 01:11:40,720 --> 01:11:45,320 GUIDING CAREGIVERS THROUGH THE 1666 01:11:45,320 --> 01:11:48,240 PROCESS AND, YOU KNOW THEY 1667 01:11:48,240 --> 01:11:49,760 PROVIDE A BRIDGE BETWEEN THE 1668 01:11:49,760 --> 01:11:52,000 SERVICES THAT ARE OUT IN THE 1669 01:11:52,000 --> 01:11:53,040 COMMUNITY AND WHAT'S GOING ON 1670 01:11:53,040 --> 01:12:02,000 IN THE HOME AND IT IS 1671 01:12:02,000 --> 01:12:02,640 CULTURALLY INFORMED WAY. 1672 01:12:02,640 --> 01:12:05,160 >>THANKS FOR THAT QUESTION. 1673 01:12:05,160 --> 01:12:07,760 AND I THINK FOR SURE CARE 1674 01:12:07,760 --> 01:12:09,960 GIVING IS A KEY ISSUE RIGHT 1675 01:12:09,960 --> 01:12:13,000 NOW FOR OUR NATION AND OUR 1676 01:12:13,000 --> 01:12:14,280 OLDER ADULTS. 1677 01:12:14,280 --> 01:12:15,360 THERE IS VERY STRONG INTEREST 1678 01:12:15,360 --> 01:12:17,920 AS YOU KNOW FROM THE 1679 01:12:17,920 --> 01:12:19,920 ADMINISTRATION RIGHT NOW SO WE 1680 01:12:19,920 --> 01:12:20,800 HAVE THAT RESOURCE AND 1681 01:12:20,800 --> 01:12:24,560 ATTENTION THAT IS IMPORTANT TO 1682 01:12:24,560 --> 01:12:24,920 LEVERAGE. 1683 01:12:24,920 --> 01:12:27,400 I THINK THERE IS VERY BILL 1684 01:12:27,400 --> 01:12:30,120 KNOWLEDGE AROUND CARE GIVING. 1685 01:12:30,120 --> 01:12:35,200 FOR EXAMPLE, IN SOME DIVERSE 1686 01:12:35,200 --> 01:12:37,160 POPULATIONS, IN THE HISPANIC 1687 01:12:37,160 --> 01:12:40,440 SPACE, FOR EXAMPLE, MANY 1688 01:12:40,440 --> 01:12:41,720 CAREGIVERS DON'T SELF-IDENTIFY 1689 01:12:41,720 --> 01:12:43,880 AS CAREGIVERS AND THAT ALONE 1690 01:12:43,880 --> 01:12:45,920 IS A HUGE CHALLENGE BECAUSE IF 1691 01:12:45,920 --> 01:12:47,800 THEY DON'T THINK THEY ARE 1692 01:12:47,800 --> 01:12:49,400 CAREGIVERS, HOW WILL THEY LOOK 1693 01:12:49,400 --> 01:12:51,360 FOR RESOURCES, ASK FOR HELP? 1694 01:12:51,360 --> 01:12:54,120 SO I AM GLAD YOU BROUGHT THAT 1695 01:12:54,120 --> 01:12:56,480 UP AND I THINK IT IS AN 1696 01:12:56,480 --> 01:13:01,960 IMPORTANT ISSUE TO ADDRESS. 1697 01:13:01,960 --> 01:13:04,120 >>MAY I JUST FILL IN THAT, I 1698 01:13:04,120 --> 01:13:05,400 THINK WE NEED TO CONSIDER 1699 01:13:05,400 --> 01:13:08,960 THOSE WHO ARE LIVING ALONE 1700 01:13:08,960 --> 01:13:10,800 WITH ALZHEIMER'S AND RELATED 1701 01:13:10,800 --> 01:13:12,960 DEMENTIAS AND I DON'T KNOW THE 1702 01:13:12,960 --> 01:13:14,240 CURRENT STATISTICS BUT THERE 1703 01:13:14,240 --> 01:13:16,480 ARE QUITE A NUMBER. 1704 01:13:16,480 --> 01:13:18,680 FOR FOLKS, HOW DO WE PROVIDE 1705 01:13:18,680 --> 01:13:20,040 SUPPORT AND SERVICES AND 1706 01:13:20,040 --> 01:13:20,920 MOBILIZE THE RESOURCE 1707 01:13:20,920 --> 01:13:21,800 NECESSARY TO SUPPORT PEOPLE 1708 01:13:21,800 --> 01:13:24,160 WHERE THEY ARE AND HELP THEM 1709 01:13:24,160 --> 01:13:27,520 AS THE DISEASE PROGRESSES. 1710 01:13:27,520 --> 01:13:29,160 >>JUST AS A FOLLOW UP TO THAT 1711 01:13:29,160 --> 01:13:34,320 COMMENT, AND I THINK IT IS SO 1712 01:13:34,320 --> 01:13:36,600 TRUE, AND CERTAINLY PART OF 1713 01:13:36,600 --> 01:13:38,400 THE DISCUSSION IN WISCONSIN, 1714 01:13:38,400 --> 01:13:41,160 THE ONE THING WE HAVE LEARNED 1715 01:13:41,160 --> 01:13:41,800 IN UNDER REPRESENTED 1716 01:13:41,800 --> 01:13:43,400 COMMUNITIES FOR OVER A DECADE 1717 01:13:43,400 --> 01:13:46,800 NOW FROM THE OAT SIDE, VERY 1718 01:13:46,800 --> 01:13:49,200 FORTUNATE TO HAVE A LARGE 1719 01:13:49,200 --> 01:13:51,600 COHORT OF NATIVE AMERICANS AND 1720 01:13:51,600 --> 01:13:52,520 AFRICAN-AMERICANS DOING 1721 01:13:52,520 --> 01:13:54,160 RESEARCH FOR US BUT OVER THAT 1722 01:13:54,160 --> 01:13:56,360 TIME AS Dr. MANLY MENTIONED, 1723 01:13:56,360 --> 01:13:58,000 IT TAKES TIME TO DEVELOP THEIR 1724 01:13:58,000 --> 01:13:58,440 TRUST. 1725 01:13:58,440 --> 01:14:02,000 BUT AT THE SAME TIME, IT IS 1726 01:14:02,000 --> 01:14:02,960 WELL-KNOWN TO PROVIDE SERVICE 1727 01:14:02,960 --> 01:14:06,560 TO THEM AND THE SERVICE WE 1728 01:14:06,560 --> 01:14:10,000 HAVE DONE, SUCH AS COMPUTER 1729 01:14:10,000 --> 01:14:11,280 CLASSES, FOOD, THE PEOPLE LIKE 1730 01:14:11,280 --> 01:14:11,600 THAT. 1731 01:14:11,600 --> 01:14:13,680 SO THOSE KIND OF ONGOING 1732 01:14:13,680 --> 01:14:14,520 SERVICES MAKE THE COMMUNITY 1733 01:14:14,520 --> 01:14:19,400 FEEL YOU ARE NOT JUST THERE TO 1734 01:14:19,400 --> 01:14:21,680 DO RESEARCH BUT PROVIDING YOUR 1735 01:14:21,680 --> 01:14:27,000 TIME AND THEY NEED HELP ON AN 1736 01:14:27,000 --> 01:14:28,280 ONGOING BASIS WHETHER YOU ARE 1737 01:14:28,280 --> 01:14:29,080 DOING RESEARCH OR NOT. 1738 01:14:29,080 --> 01:14:31,720 AND I THINK THAT IS VERY 1739 01:14:31,720 --> 01:14:34,560 HELPFUL AND DOES GET MORE 1740 01:14:34,560 --> 01:14:35,760 STRENGTHENED THAT WE ARE THERE 1741 01:14:35,760 --> 01:14:38,840 TO HELP YOU BUT IT HAS TO BE 1742 01:14:38,840 --> 01:14:41,160 ON AN ONGOING BASIS AS FAR AS 1743 01:14:41,160 --> 01:14:43,800 RESOURCES AND YOU CAN GET IT, 1744 01:14:43,800 --> 01:14:45,200 YOU KNOW, FROM DIFFERENT MEANS 1745 01:14:45,200 --> 01:14:53,360 BUT THEN ALL OF THE SERVICES. 1746 01:14:53,360 --> 01:14:56,960 >>YOU KNOW JUST OUT OF 1747 01:14:56,960 --> 01:14:58,480 CURIOSITY, I DON'T THINK I 1748 01:14:58,480 --> 01:15:00,280 FORMULATED MY QUESTION AS WELL 1749 01:15:00,280 --> 01:15:01,600 AS I THOUGHT I DID WHICH IS 1750 01:15:01,600 --> 01:15:06,200 KIND OF THE NEED FOR 1751 01:15:06,200 --> 01:15:08,720 CAREGIVERS AS YOUR DEMENTIA 1752 01:15:08,720 --> 01:15:10,760 PROGRESSES, THAT IN AND OF 1753 01:15:10,760 --> 01:15:12,640 ITSELF A BARRIER TO 1754 01:15:12,640 --> 01:15:13,280 PARTICIPATION IN RESEARCH? 1755 01:15:13,280 --> 01:15:15,160 AND THAT IS REALLY WHERE I WAS 1756 01:15:15,160 --> 01:15:16,880 KIND OF GOING WITH THAT 1757 01:15:16,880 --> 01:15:17,320 QUESTION. 1758 01:15:17,320 --> 01:15:19,720 I WAS WONDERING LIKE FROM YOUR 1759 01:15:19,720 --> 01:15:21,800 DIRECT EXPERIENCE, DO YOU SEE 1760 01:15:21,800 --> 01:15:30,040 THAT AS A BARRIER TO ACTUALLY 1761 01:15:30,040 --> 01:15:32,280 ENROLLING PEOPLE IN THE STUDY 1762 01:15:32,280 --> 01:15:34,400 SO I THINK THAT IS WHAT I WAS 1763 01:15:34,400 --> 01:15:37,120 TRYING TO IMPRESS US TO THINK 1764 01:15:37,120 --> 01:15:41,000 ABOUT, SORT OF THE, YOU 1765 01:15:41,000 --> 01:15:43,280 KNOW -- SO HAVING A CAREGIVER 1766 01:15:43,280 --> 01:15:46,080 WHO IS UNABLE TO HELP YOU TO 1767 01:15:46,080 --> 01:15:47,720 PARTICIPATE IN RESEARCH AND 1768 01:15:47,720 --> 01:15:49,360 WHETHER THERE IS THINGS YOU 1769 01:15:49,360 --> 01:15:53,760 CAN DO AND THEN FURTHER TO THE 1770 01:15:53,760 --> 01:15:57,400 POINT ABOUT LIVING ALONE, THAT 1771 01:15:57,400 --> 01:16:02,200 IS ALSO CAN BE A BARRIER TO 1772 01:16:02,200 --> 01:16:05,280 PARTICIPATING IN RESEARCH, SO 1773 01:16:05,280 --> 01:16:12,880 IT IS DOUBLE-EDGED FOR THIS 1774 01:16:12,880 --> 01:16:14,760 NEXT GENERATION -- 1775 01:16:14,760 --> 01:16:15,240 [INDISCERNIBLE] 1776 01:16:15,240 --> 01:16:17,160 >>AND NOT ONLY FOR 1777 01:16:17,160 --> 01:16:19,320 ALZHEIMER'S RIGHT? 1778 01:16:19,320 --> 01:16:22,080 I THINK THE HEALTH IN TIME 1779 01:16:22,080 --> 01:16:25,360 SURVEY MIGHT BE USEFUL TO FIND 1780 01:16:25,360 --> 01:16:26,840 OUT HOW THEY HANDLE THAT. 1781 01:16:26,840 --> 01:16:32,040 I MEAN WE HAVE A LOT OF 1782 01:16:32,040 --> 01:16:36,280 SURVEYS OUT THERE WITH FOLKS 1783 01:16:36,280 --> 01:16:37,040 PARTICIPATING IN STUDIES. 1784 01:16:37,040 --> 01:16:39,880 IT IS NOT A NEW THING FOR NIA. 1785 01:16:39,880 --> 01:16:44,480 BUT WHETHER OR NOT IT HAS BEEN 1786 01:16:44,480 --> 01:16:46,760 WISDOM COLLECTED IN ONE PLACE, 1787 01:16:46,760 --> 01:16:49,120 THAT COULD THEN BE RESOURCED 1788 01:16:49,120 --> 01:16:51,080 FOR OTHERS, I DON'T KNOW THAT 1789 01:16:51,080 --> 01:16:51,760 THAT'S BEEN DONE. 1790 01:16:51,760 --> 01:16:53,720 >>AND JUST FOR EVERYONE'S 1791 01:16:53,720 --> 01:16:57,120 INFORMATION, WE JUST HOSTED A 1792 01:16:57,120 --> 01:16:58,840 LARGE SUMMIT, A 3-DAY SUMMIT 1793 01:16:58,840 --> 01:17:01,400 AT THE END OF MARCH OF THIS 1794 01:17:01,400 --> 01:17:05,040 YEAR ON CARE SERVICES SUPPORT 1795 01:17:05,040 --> 01:17:06,440 FOR PERSONS LIVING WITH DEMENT 1796 01:17:06,440 --> 01:17:09,160 SHALL AND THEIR CARE PARTNERS 1797 01:17:09,160 --> 01:17:10,680 AND CAREGIVERS SO A REPORT ON 1798 01:17:10,680 --> 01:17:12,640 THAT WILL BE COMING OUT 1799 01:17:12,640 --> 01:17:15,160 SHORTLY SO STAY TUNED FOR THAT 1800 01:17:15,160 --> 01:17:17,920 TOO, WHICH HAD A LOT OF REALLY 1801 01:17:17,920 --> 01:17:19,760 VALUABLE INFORMATION IN THIS 1802 01:17:19,760 --> 01:17:20,320 PARTICULAR ROUND. 1803 01:17:20,320 --> 01:17:21,440 >>ALL RIGHT, THANK YOU AND I 1804 01:17:21,440 --> 01:17:23,800 WANTED TO FOLLOW UP ON NANCY'S 1805 01:17:23,800 --> 01:17:25,640 POINT AND ALSO PUT IN A 1806 01:17:25,640 --> 01:17:28,480 REQUEST IF THIS COULD BE AN 1807 01:17:28,480 --> 01:17:32,520 AGENDA ITEM AT A FUTURE 1808 01:17:32,520 --> 01:17:32,880 MEETINGS. 1809 01:17:32,880 --> 01:17:36,320 I THINK NOT ONLY FOR DEMENTIA 1810 01:17:36,320 --> 01:17:38,280 PATIENTS, A LOT OF OLDER 1811 01:17:38,280 --> 01:17:39,680 PATIENTS, IF THEIR FAMILY 1812 01:17:39,680 --> 01:17:40,840 MEMBERS CAN'T ACCOMPANY WITH 1813 01:17:40,840 --> 01:17:42,800 THEM, PARTICIPATE WITH THEM, 1814 01:17:42,800 --> 01:17:44,880 TRANSPORT THEM, THEY CAN'T 1815 01:17:44,880 --> 01:17:47,200 PARTICIPATE IN STUDIES, EVEN 1816 01:17:47,200 --> 01:17:48,360 WITHOUT COGNITIVE IMPAIRMENT 1817 01:17:48,360 --> 01:17:50,520 AND IT TENDS TO BE AFTERNOON 1818 01:17:50,520 --> 01:17:54,800 MORE SO IN UNDER REPRESENTED 1819 01:17:54,800 --> 01:17:56,520 POPULATIONS, EITHER BECAUSE OF 1820 01:17:56,520 --> 01:17:58,760 DISTRUST OR LANGUAGE ISSUES OR 1821 01:17:58,760 --> 01:18:00,880 CULTURAL ISSUES, IT IS JUST 1822 01:18:00,880 --> 01:18:05,200 REALLY AN ISSUE AND ON TOP OF 1823 01:18:05,200 --> 01:18:06,960 THAT, IRBS WON'T RECOGNIZE THE 1824 01:18:06,960 --> 01:18:10,360 NEED TO PAY ADDITIONAL 1825 01:18:10,360 --> 01:18:12,720 INCENTIVE FOR BOTH THE PATIENT 1826 01:18:12,720 --> 01:18:14,600 AND THE CAREGIVER AND THE 1827 01:18:14,600 --> 01:18:16,760 TRANSPORTATION COST OF THE 1828 01:18:16,760 --> 01:18:18,120 CAREGIVER AND PERHAPS CHILD 1829 01:18:18,120 --> 01:18:20,280 CARE COSTS FOR THE CAREGIVER 1830 01:18:20,280 --> 01:18:22,640 WHO IS OFTEN, YOU KNOW, TAKING 1831 01:18:22,640 --> 01:18:24,920 CARE OF CHILDREN OR 1832 01:18:24,920 --> 01:18:26,720 GRANDCHILDREN AND SO THIS 1833 01:18:26,720 --> 01:18:30,040 ISSUE OF THE NEED FOR UNEQUAL 1834 01:18:30,040 --> 01:18:31,560 INCENTIVES, IT IS A HUGE ISSUE 1835 01:18:31,560 --> 01:18:34,400 AND I AM WONDERING IF IT IS 1836 01:18:34,400 --> 01:18:37,760 ONE WE COULD EVEN ADDRESS WITH 1837 01:18:37,760 --> 01:18:41,520 OHIT OR HAVING A BROADER 1838 01:18:41,520 --> 01:18:41,920 DISCUSSION. 1839 01:18:41,920 --> 01:18:44,120 BECAUSE I THINK THAT IS A HUGE 1840 01:18:44,120 --> 01:18:49,000 ISSUE TO BE ADDRESSED TO BE 1841 01:18:49,000 --> 01:18:52,880 INVOLVED IN OUR STUDIES. 1842 01:18:52,880 --> 01:18:54,480 >>GREAT SUGGESTION, THANK YOU 1843 01:18:54,480 --> 01:18:55,320 SHARON. 1844 01:18:55,320 --> 01:18:55,760 WE MADE NOTES. 1845 01:18:55,760 --> 01:18:57,280 >>I WANT TO BACK THAT UP 1846 01:18:57,280 --> 01:18:57,720 STRONGLY. 1847 01:18:57,720 --> 01:19:01,960 THIS HAS BEEN IN THE AIDR 1848 01:19:01,960 --> 01:19:04,720 WORLD, I HAVE BEEN ON THAT 1849 01:19:04,720 --> 01:19:05,680 BANDWAGON BY REQUIRING THERE 1850 01:19:05,680 --> 01:19:08,200 TO BE A STUDY PARTNER, WE ARE 1851 01:19:08,200 --> 01:19:09,520 EXCLUDING A HUGE NUMBER OF 1852 01:19:09,520 --> 01:19:11,800 PEOPLE WHO COULD BE IN OUR 1853 01:19:11,800 --> 01:19:14,640 STUDY AND THEY HAVE GOOD 1854 01:19:14,640 --> 01:19:16,600 ARGUMENTS FOR HAVING THEM, TO 1855 01:19:16,600 --> 01:19:18,320 GET BETTER DATA ON PEOPLE, 1856 01:19:18,320 --> 01:19:20,440 ESPECIALLY ONCE THEY ARE 1857 01:19:20,440 --> 01:19:23,000 IMPAIRED, YOU GET BETTER DATA 1858 01:19:23,000 --> 01:19:24,200 FROM SOMEONE TELLING THEM 1859 01:19:24,200 --> 01:19:25,480 SOMETHING SO WE UNDERSTAND 1860 01:19:25,480 --> 01:19:28,000 THAT BUT WE SHOULD BE USING 1861 01:19:28,000 --> 01:19:29,280 TECHNOLOGY, OTHER THINGS WE 1862 01:19:29,280 --> 01:19:31,640 CAN USE TO GET ANSWERS TO 1863 01:19:31,640 --> 01:19:32,120 THOSE QUESTIONS. 1864 01:19:32,120 --> 01:19:33,400 I DON'T THINK WE SHOULD 1865 01:19:33,400 --> 01:19:35,120 EXCLUDE THEM AND SAY YOU LIVE 1866 01:19:35,120 --> 01:19:37,600 ALONE, YOU ARE AN OLDER ADULT, 1867 01:19:37,600 --> 01:19:40,120 YOU CANNOT BE IN OUR STUDY AND 1868 01:19:40,120 --> 01:19:45,680 NOT TO PUT ANYBODY ON THE SPOT 1869 01:19:45,680 --> 01:19:48,200 BUT THEN INCENTIVE PROGRAMS, 1870 01:19:48,200 --> 01:19:51,600 WE ARE REQUIRED TO GET STUDY 1871 01:19:51,600 --> 01:19:54,000 PARTNERS ON OUR PARTICIPANTS, 1872 01:19:54,000 --> 01:19:54,800 REQUIRED. 1873 01:19:54,800 --> 01:19:57,480 SO PEOPLE WHO DON'T HAVE -- SO 1874 01:19:57,480 --> 01:19:58,960 IN OUR COHORTS, PEOPLE WHO 1875 01:19:58,960 --> 01:20:03,600 DON'T HAVE SOMEBODY ALREADY 1876 01:20:03,600 --> 01:20:09,960 AWHO HAS SIGNED AN AGREEMENT 1877 01:20:09,960 --> 01:20:11,920 FOR THE STUDY, THOSE ARE THE 1878 01:20:11,920 --> 01:20:14,120 ONLY PEOPLE WE CAN GO TO FOR 1879 01:20:14,120 --> 01:20:15,920 ENROLLMENT IN OUR STUDY. 1880 01:20:15,920 --> 01:20:17,560 SO THERE ARE PEOPLE WE DON'T 1881 01:20:17,560 --> 01:20:18,840 WANT TO EXCLUDE AND THERE ARE 1882 01:20:18,840 --> 01:20:22,000 GOING TO BE THOSE OLDER PEOPLE 1883 01:20:22,000 --> 01:20:23,280 WHO ARE ALONE IN THE COMMUNITY 1884 01:20:23,280 --> 01:20:29,640 SO THANK YOU FOR THAT. 1885 01:20:29,640 --> 01:20:30,240 >>SUSAN? 1886 01:20:30,240 --> 01:20:32,160 >>ONE OTHER THING TO THINK 1887 01:20:32,160 --> 01:20:34,400 ABOUT IN A SENIOR COMMUNITY 1888 01:20:34,400 --> 01:20:37,920 WHERE THEY HAVE ALZHEIMER'S 1889 01:20:37,920 --> 01:20:40,720 UNITS, THEY HAVE PEOPLE THERE 1890 01:20:40,720 --> 01:20:42,640 ACTUALLY RELATIVELY 1891 01:20:42,640 --> 01:20:43,360 INDEPENDENT IN ASSISTED 1892 01:20:43,360 --> 01:20:45,640 LIVING, SO THEY HAVE A WHOLE 1893 01:20:45,640 --> 01:20:46,200 GROUP. 1894 01:20:46,200 --> 01:20:48,160 THE RESEARCH CAN BE BROUGHT TO 1895 01:20:48,160 --> 01:20:49,120 THEM SUCCESSFULLY SO THEY 1896 01:20:49,120 --> 01:20:51,360 DON'T HAVE TO GO OUT OF WHERE 1897 01:20:51,360 --> 01:20:53,720 THEY ARE LIVING BUT THEY CAN 1898 01:20:53,720 --> 01:20:54,120 PARTICIPATE. 1899 01:20:54,120 --> 01:20:55,800 NOW CERTAIN THINGS CAN BE 1900 01:20:55,800 --> 01:20:58,400 DONE, LIKE MAYBE A MRI, BUT 1901 01:20:58,400 --> 01:21:00,280 THERE ARE A LOT OF TESTING 1902 01:21:00,280 --> 01:21:04,320 THAT CAN BE DONE ON THE 1903 01:21:04,320 --> 01:21:04,680 OUTSIDE. 1904 01:21:04,680 --> 01:21:06,640 FURTHERMORE, THOSE WITH 1905 01:21:06,640 --> 01:21:08,240 ASSISTANCE WITH IT, THEY ARE 1906 01:21:08,240 --> 01:21:09,920 ABLE TO BRING ELECTRONIC 1907 01:21:09,920 --> 01:21:11,480 EQUIPMENT OR WHATEVER THEY 1908 01:21:11,480 --> 01:21:12,680 NEED, TESTS, OUT TO THE 1909 01:21:12,680 --> 01:21:13,040 COMMUNITY. 1910 01:21:13,040 --> 01:21:21,560 SOMETIMES IT CAN BE DONE IN 1911 01:21:21,560 --> 01:21:23,480 CENTERS, CHURCHES, YMCAS, WE 1912 01:21:23,480 --> 01:21:24,520 CAN GET ASSISTANCE THERE 1913 01:21:24,520 --> 01:21:31,120 RATHER THAN HAVING TO COME IN 1914 01:21:31,120 --> 01:21:31,680 FROM OTHER AREAS. 1915 01:21:31,680 --> 01:21:33,200 >>I SPEAK FROM EXPERIENCE? 1916 01:21:33,200 --> 01:21:37,600 A. MY MOTHER PASSED AWAY LAST 1917 01:21:37,600 --> 01:21:39,880 YEAR, SUFFERED FROM 1918 01:21:39,880 --> 01:21:42,960 ALZHEIMER'S FOR ABOUT FOUR 1919 01:21:42,960 --> 01:21:43,280 YEARS. 1920 01:21:43,280 --> 01:21:46,120 WE ALREADY KNEW SHE HAD 1921 01:21:46,120 --> 01:21:47,120 DEMENTIA AND DIDN'T RECOGNIZE 1922 01:21:47,120 --> 01:21:57,640 IT BUT LET ME TELL YOU TO 1923 01:21:58,440 --> 01:22:00,360 RESEARCH WAS FARTHEST FROM MY 1924 01:22:00,360 --> 01:22:03,640 MIND WITH ME AND MY OTHER FIVE 1925 01:22:03,640 --> 01:22:04,040 SIBLINGS. 1926 01:22:04,040 --> 01:22:06,160 WHAT WAS PRIMARY IN OUR MIND 1927 01:22:06,160 --> 01:22:08,680 WAS TO FIND WAYS TO ADMINISTER 1928 01:22:08,680 --> 01:22:15,760 TO HER. 1929 01:22:15,760 --> 01:22:17,600 AND THIS OTHER GROUP OF 1930 01:22:17,600 --> 01:22:19,200 FINDING RESOURCES WITHIN NIA 1931 01:22:19,200 --> 01:22:22,520 WAS NEVER ON OUR MIND. 1932 01:22:22,520 --> 01:22:33,080 WE ONLY DEALT WITH HER PCD AND 1933 01:22:33,640 --> 01:22:34,240 OCCASIONALLY ANOTHER RESOURCE 1934 01:22:34,240 --> 01:22:36,840 BUT NONE OF THEM EVER 1935 01:22:36,840 --> 01:22:38,200 MENTIONED ANYTHING ABOUT HEY 1936 01:22:38,200 --> 01:22:48,360 THERE IS THIS STUDY AND -- 1937 01:22:48,360 --> 01:22:49,400 [INDISCERNIBLE] [INAUDIBLE]. 1938 01:22:49,400 --> 01:22:55,520 NONE OF THAT HAPPENED. 1939 01:22:55,520 --> 01:22:55,960 O. 1940 01:22:55,960 --> 01:22:58,280 >>THANK YOU FOR THAT. 1941 01:22:58,280 --> 01:23:02,480 >> ONE VERY BRIEF COMMENT, 1942 01:23:02,480 --> 01:23:04,880 TALKING ABOUT RESOURCES, YOU 1943 01:23:04,880 --> 01:23:07,880 COULD GO TO RESOURCES TO GET 1944 01:23:07,880 --> 01:23:10,560 FUNDS AND SUPPORT, IN CAN YOU 1945 01:23:10,560 --> 01:23:11,760 SAYING REHAB, WE HAVE BEEN 1946 01:23:11,760 --> 01:23:15,320 WORKING WITH THE GOVERNOR'S 1947 01:23:15,320 --> 01:23:15,960 OFFICE, STATE GOVERNMENT 1948 01:23:15,960 --> 01:23:17,160 BECAUSE THEY ARE SUPPOSED TO 1949 01:23:17,160 --> 01:23:20,040 TAKE CARE OF PEOPLE WITH 1950 01:23:20,040 --> 01:23:20,480 DEMENTIA. 1951 01:23:20,480 --> 01:23:22,440 SO THE FIRST LADY OF WISCONSIN 1952 01:23:22,440 --> 01:23:24,080 AND THE GOVERNOR ARE GOING TO 1953 01:23:24,080 --> 01:23:28,480 HOST AN EVENT AT THEIR OWN 1954 01:23:28,480 --> 01:23:30,160 RESIDENCE INVITING THE LOCAL 1955 01:23:30,160 --> 01:23:32,560 MEDIA TO DRAW ATTENTION ON 1956 01:23:32,560 --> 01:23:35,080 CARE GIVING AND ALSO THE HOPE 1957 01:23:35,080 --> 01:23:41,160 IS JUST THAT THE STATE 1958 01:23:41,160 --> 01:23:42,080 GOVERNMENTS WILL HAVE FUNDS 1959 01:23:42,080 --> 01:23:45,400 RELATED TO THIS AREA SO I 1960 01:23:45,400 --> 01:23:47,520 THINK THAT THERE ARE OTHER 1961 01:23:47,520 --> 01:23:49,360 PEOPLE IN THE STATE WORKING 1962 01:23:49,360 --> 01:23:50,680 WITH STATE GOVERNMENT THAT 1963 01:23:50,680 --> 01:23:52,040 COULD BE QUITE USEFUL AND THEY 1964 01:23:52,040 --> 01:23:53,600 HAVE A INTEREST IN THIS 1965 01:23:53,600 --> 01:23:55,320 BECAUSE THEY HAVE PEOPLE WHO 1966 01:23:55,320 --> 01:23:56,520 ARE SUFFERING. 1967 01:23:56,520 --> 01:23:57,480 >>ABSOLUTELY. 1968 01:23:57,480 --> 01:24:00,240 THANK YOU ALL FOR THESE VERY 1969 01:24:00,240 --> 01:24:03,160 VALUABLE COMMENTS, TOO, AND I 1970 01:24:03,160 --> 01:24:06,280 ASSURE YOU PAUSE WE DID HOST A 1971 01:24:06,280 --> 01:24:06,920 DIFFERENT SUMMIT RECENTLY, 1972 01:24:06,920 --> 01:24:09,160 THIS IS A HIGH PRIORITY FOR 1973 01:24:09,160 --> 01:24:11,760 THE INSTITUTE TOO AND THERE 1974 01:24:11,760 --> 01:24:12,600 ARE CERTAINLY RESEARCH BEING 1975 01:24:12,600 --> 01:24:14,600 DONE IN THIS AREA AND MORE TO 1976 01:24:14,600 --> 01:24:16,840 COME FOR SURE, TOO, BECAUSE 1977 01:24:16,840 --> 01:24:18,360 OBVIOUSLY IT HAS BEEN -- WE 1978 01:24:18,360 --> 01:24:20,880 HAVE HEARD THIS FROM THE 1979 01:24:20,880 --> 01:24:24,160 COMMUNITY AND JOHN, YOU CAN 1980 01:24:24,160 --> 01:24:27,400 COMMENT, TOO ON -- 1981 01:24:27,400 --> 01:24:29,840 >>I WOULD COMMENT, RESEARCH 1982 01:24:29,840 --> 01:24:32,360 FOR A WIDE RANGE OF THESE 1983 01:24:32,360 --> 01:24:33,840 AREAS ON MULTITUDE TOPICS BUT 1984 01:24:33,840 --> 01:24:35,520 ONE THING I WANT TO 1985 01:24:35,520 --> 01:24:38,240 PARTICULARLY POINT OUT LAST 1986 01:24:38,240 --> 01:24:41,240 MARCH ABOUT NHAS STUDY WHICH 1987 01:24:41,240 --> 01:24:42,760 HAS NOW INCREASING AMOUNT OF 1988 01:24:42,760 --> 01:24:47,040 DATA NOT JUST ABOUT THE 1989 01:24:47,040 --> 01:24:48,120 MEDICARE POPULATION BUT 1990 01:24:48,120 --> 01:24:51,400 ACTUALLY TESTING A NUMBER OF 1991 01:24:51,400 --> 01:24:59,640 THEM SO HOPEFULLY CAN GET MORE 1992 01:24:59,640 --> 01:25:01,160 INTO THESE PLACES -- 1993 01:25:01,160 --> 01:25:01,720 [INAUDIBLE] 1994 01:25:01,720 --> 01:25:03,520 >>THANK YOU, JOHN AND THEN 1995 01:25:03,520 --> 01:25:05,320 JUST CIRCLING BACK TO ONE OF 1996 01:25:05,320 --> 01:25:06,600 YOUR ORIGINAL QUESTIONS OF 1997 01:25:06,600 --> 01:25:09,560 WHAT WE'RE TRYING TO DO WITH 1998 01:25:09,560 --> 01:25:11,640 THESE VALUABLE PRESENTATIONS 1999 01:25:11,640 --> 01:25:13,720 WE HAD GOING TO THE CHANCE 2000 01:25:13,720 --> 01:25:15,720 BOARD ABOUT LESSONS LEARNED IN 2001 01:25:15,720 --> 01:25:17,000 RECRUITMENT THEN TOO AND YES, 2002 01:25:17,000 --> 01:25:19,640 THIS IS THE REASON WE BROUGHT 2003 01:25:19,640 --> 01:25:22,400 THIS FORWARD TOO IN THE TASK 2004 01:25:22,400 --> 01:25:23,640 FORCE PRESENTATION BECAUSE IT 2005 01:25:23,640 --> 01:25:26,760 IS A REAL SUCCESS STORY AND 2006 01:25:26,760 --> 01:25:28,800 MODEL FOR HOPEFULLY LESSONS 2007 01:25:28,800 --> 01:25:31,880 LEARNED FOR THE REST OF OUR 2008 01:25:31,880 --> 01:25:32,600 COMMUNITY. 2009 01:25:32,600 --> 01:25:33,880 SO WE'RE TAKING THOSE 2010 01:25:33,880 --> 01:25:36,080 COMMENTS, YOU KNOW SERIOUSLY 2011 01:25:36,080 --> 01:25:39,000 AND REALLY LOOKING MORE INTO 2012 01:25:39,000 --> 01:25:40,960 COMMUNITY BASED RESEARCH AND, 2013 01:25:40,960 --> 01:25:43,320 YOU KNOW, OTHER STRATEGIES FOR 2014 01:25:43,320 --> 01:25:44,280 RECRUITMENT AND THIS IS 2015 01:25:44,280 --> 01:25:46,280 SOMETHING THAT WE ARE GOING TO 2016 01:25:46,280 --> 01:25:48,560 MONITOR CLOSELY IN OUR 2017 01:25:48,560 --> 01:25:49,720 CLINICAL RESEARCH OFFICE NOW 2018 01:25:49,720 --> 01:25:53,880 AND WHEN WE SEE THAT THERE ARE 2019 01:25:53,880 --> 01:25:57,720 -- BECAUSE OF OUR CROEM 2020 01:25:57,720 --> 01:25:59,640 SYSTEM, WE CAN VISUALIZE WHEN 2021 01:25:59,640 --> 01:26:01,200 PEOPLE ARE FALLING BEHIND IN 2022 01:26:01,200 --> 01:26:02,440 RECRUITMENT AND TRY TO 2023 01:26:02,440 --> 01:26:04,720 UNDERSTAND WHY AND STEP IN AND 2024 01:26:04,720 --> 01:26:06,240 HELP BECAUSE WE HAVE A LOT OF 2025 01:26:06,240 --> 01:26:07,920 THIS INFORMATION AT OUR 2026 01:26:07,920 --> 01:26:08,960 FINGERTIPS, TOO. 2027 01:26:08,960 --> 01:26:11,800 WE CAN LINK PEOPLE TO OTHER 2028 01:26:11,800 --> 01:26:13,320 GROUPS TOO IN MANY WAYS AND 2029 01:26:13,320 --> 01:26:17,400 HOPE THIS CAN MAKE OUR TRIALS 2030 01:26:17,400 --> 01:26:23,000 MUCH MORE SUCCESSFUL BUT EVEN 2031 01:26:23,000 --> 01:26:26,080 WHEN TRYING TO DO PREVENTION 2032 01:26:26,080 --> 01:26:28,480 TOO, WHEN THESE REPORTS COME 2033 01:26:28,480 --> 01:26:31,640 IN, WEAR' REALLY ENGAGING OUR 2034 01:26:31,640 --> 01:26:33,760 RESEARCHERS TO ENSURE TEASE 2035 01:26:33,760 --> 01:26:35,280 TYPE OF STRATEGIES ARE FLESHED 2036 01:26:35,280 --> 01:26:37,680 OUT AND UNDERSTOOD AND HOPE 2037 01:26:37,680 --> 01:26:39,760 FOR SUCCESS IN OUR TRIAL 2038 01:26:39,760 --> 01:26:41,880 RESEARCH TOO SO DOING A LOT OF 2039 01:26:41,880 --> 01:26:43,720 DIFFERENT AVENUES OF HELPING 2040 01:26:43,720 --> 01:26:45,000 OUR COMMUNITY AS MUCH AS 2041 01:26:45,000 --> 01:26:46,600 POSSIBLE IN THESE AREAS. 2042 01:26:46,600 --> 01:26:47,880 BUT WE UNDERSTAND, TOO, THAT 2043 01:26:47,880 --> 01:26:50,600 THIS IS NO EASY TASK AND WE DO 2044 01:26:50,600 --> 01:26:52,920 NEED TO THINK ABOUT BUILDING 2045 01:26:52,920 --> 01:26:54,080 INFRASTRUCTURE IN THESE AREAS 2046 01:26:54,080 --> 01:26:56,440 TOO TO HELP OVERALL THE 2047 01:26:56,440 --> 01:26:58,200 COMMUNITY TOO AND THAT IS ON 2048 01:26:58,200 --> 01:27:00,680 THE HORIZON FOR SURE, TOO, 2049 01:27:00,680 --> 01:27:02,560 BESIDES WHAT WE HAVE ALREADY 2050 01:27:02,560 --> 01:27:03,640 DONE BUT WE KNOW THERE IS 2051 01:27:03,640 --> 01:27:09,840 STILL A LOT MORE TO COME. 2052 01:27:09,840 --> 01:27:14,160 ALL RIGHT, WE CAN THEN MOVE ON 2053 01:27:14,160 --> 01:27:16,320 TO OUR NEXT REPORT ON THE 2054 01:27:16,320 --> 01:27:18,200 WORKING GROUP ON PROGRAM AND 2055 01:27:18,200 --> 01:27:21,960 OUR CHAIR IS Dr. SUSAN 2056 01:27:21,960 --> 01:27:24,560 GREENSPAN SO SUSAN? 2057 01:27:24,560 --> 01:27:25,000 >>THANKS, KEN. 2058 01:27:25,000 --> 01:27:28,000 SO I THINK FIRST WE WILL START 2059 01:27:28,000 --> 01:27:30,800 WITH A CONCEPT THAT WE 2060 01:27:30,800 --> 01:27:34,080 DISCUSSED, THE CONCEPT WAS 2061 01:27:34,080 --> 01:27:37,080 ENTITLED TECHNOLOGY TO 2062 01:27:37,080 --> 01:27:38,800 FACILITATE CHARACTERIZATION OF 2063 01:27:38,800 --> 01:27:42,560 THE UNDER RESOURCED POPULATION 2064 01:27:42,560 --> 01:27:43,720 FOR ADRD STUDIES. 2065 01:27:43,720 --> 01:27:46,400 DOCTOR LONGO WAS THE PRIMARY 2066 01:27:46,400 --> 01:27:50,880 REVIEWER AND Dr. RUBEN WAS 2067 01:27:50,880 --> 01:27:52,240 THE SECONDARY VIEWER. 2068 01:27:52,240 --> 01:27:54,040 DOCTOR LONGO IF YOU COULD 2069 01:27:54,040 --> 01:27:55,840 PLEASE SUMMARIZE THE CONCEPTS 2070 01:27:55,840 --> 01:27:57,320 AND DISCUSSION? 2071 01:27:57,320 --> 01:27:58,120 >>SURE, THANK YOU. 2072 01:27:58,120 --> 01:28:01,160 THE PREMISE OF THIS CONCEPT 2073 01:28:01,160 --> 01:28:05,200 PROPOSAL WAS THAT THE EXPOSOM 2074 01:28:05,200 --> 01:28:07,840 PLAYED A SIGNIFICANT ROLE IN 2075 01:28:07,840 --> 01:28:15,000 AGE RELATED DISEASES AND THE 2076 01:28:15,000 --> 01:28:16,240 CHARACTERIZED EXPOSOME 2077 01:28:16,240 --> 01:28:18,080 REQUIRES BOTH MENTAL AND 2078 01:28:18,080 --> 01:28:20,360 BIOLOGICAL SAMPLES SO THE GOAL 2079 01:28:20,360 --> 01:28:21,760 HERE IS TO CREATE TECHNOLOGY 2080 01:28:21,760 --> 01:28:24,320 THAT COULD BE USED BY 2081 01:28:24,320 --> 01:28:25,320 CAREGIVERS AND SUBJECTS 2082 01:28:25,320 --> 01:28:27,840 THEMSELVES IN ANY SITUATION OR 2083 01:28:27,840 --> 01:28:30,960 LOCATION SO THAT WOULD THEREBY 2084 01:28:30,960 --> 01:28:33,680 ALLOW A WIDE AND DIVERSE RANGE 2085 01:28:33,680 --> 01:28:35,200 OF SUBJECTS AND CAREGIVERS 2086 01:28:35,200 --> 01:28:36,560 THAT PREVIOUSLY HAD NOT BEEN 2087 01:28:36,560 --> 01:28:39,600 ABLE TO PARTICIPATE IN THESE 2088 01:28:39,600 --> 01:28:41,800 TYPE OF EXPOSOME STUDIES TO 2089 01:28:41,800 --> 01:28:44,440 BETTER PARTICIPATE AND THEN TO 2090 01:28:44,440 --> 01:28:48,160 THEREFORE CAPTURE A WIDER 2091 01:28:48,160 --> 01:28:50,800 RANGE OF PARTICIPANTS 2092 01:28:50,800 --> 01:28:53,680 CHARACTERIZATION IN THE 2093 01:28:53,680 --> 01:28:54,280 EXPOSOME. 2094 01:28:54,280 --> 01:28:56,640 SO THAT WILL ADDRESS AT LEAST 2095 01:28:56,640 --> 01:28:59,480 THREE FUNDAMENTAL GOALS OF THE 2096 01:28:59,480 --> 01:29:01,920 NIA AND CREATING STUDIES TO BE 2097 01:29:01,920 --> 01:29:02,720 USED BY CAREGIVERS THAT WOULD 2098 01:29:02,720 --> 01:29:04,120 BE A NEW APPROACH. 2099 01:29:04,120 --> 01:29:08,760 AND SO WE SAW, I THINK, 2100 01:29:08,760 --> 01:29:14,000 SUPPORTS FOR THIS CONCEPT. 2101 01:29:14,000 --> 01:29:19,440 >>THANK YOU, Dr. LONGO. 2102 01:29:19,440 --> 01:29:20,920 DOCTOR REUBEN, YOU HAVE 2103 01:29:20,920 --> 01:29:22,720 ANYTHING TO ADD? 2104 01:29:22,720 --> 01:29:24,880 >>NO, I WOULD JUST SAY I 2105 01:29:24,880 --> 01:29:26,520 SUPPORT AND THE SHORT TERM WAS 2106 01:29:26,520 --> 01:29:27,880 ABOUT THE TECHNOLOGY AND 2107 01:29:27,880 --> 01:29:32,320 LONG-TERM GOAL WAS ABOUT THE 2108 01:29:32,320 --> 01:29:34,640 OPTIONS TO HELP UNDER 2109 01:29:34,640 --> 01:29:35,520 RESOURCED POPULATIONS. 2110 01:29:35,520 --> 01:29:36,320 >>SO OVERALL THERE WAS 2111 01:29:36,320 --> 01:29:37,600 GENERAL ENTHUSIASM FOR THE 2112 01:29:37,600 --> 01:29:39,040 CONCEPT AND THE COUNCIL AGREED 2113 01:29:39,040 --> 01:29:40,440 TO MOVE FORWARD AND VOTED TO 2114 01:29:40,440 --> 01:29:42,480 MOVE FORWARD WITH THE CONCEPT. 2115 01:29:42,480 --> 01:29:51,120 THE SECOND THING WE WOULD LIKE 2116 01:29:51,120 --> 01:29:55,880 TO DISCUSS IS THE ROLL F ROLL 2117 01:29:55,880 --> 01:30:01,680 F REPORT FOR THE DEA/OSEP 2118 01:30:01,680 --> 01:30:08,800 PROCESS AND I THINK Dr. 2119 01:30:08,800 --> 01:30:11,080 KIZOWSKY IS ON THE LINE TO 2120 01:30:11,080 --> 01:30:11,760 TALK ABOUT THAT. 2121 01:30:11,760 --> 01:30:13,760 >>YES, I AM HERE, LET ME 2122 01:30:13,760 --> 01:30:16,520 SHARE MY SCREEN WITH YOU. 2123 01:30:16,520 --> 01:30:17,200 YES, THANK YOU. 2124 01:30:17,200 --> 01:30:19,520 IF THERE IS SOME PROBLEM WITH 2125 01:30:19,520 --> 01:30:24,960 THE VIDEO LET ME KNOW. 2126 01:30:24,960 --> 01:30:27,000 -- KRITCHEVSKY. 2127 01:30:27,000 --> 01:30:29,200 THIS GROUP WAS ENPANELLED LATE 2128 01:30:29,200 --> 01:30:32,040 LAST YEAR, THE COMMITTEE 2129 01:30:32,040 --> 01:30:33,400 ROSTERS HERE, MOSTLY CURRENT 2130 01:30:33,400 --> 01:30:37,080 AND FORMER COUNCIL MEMBERS BUT 2131 01:30:37,080 --> 01:30:39,760 SOME OTHER NOTABLE LINES ALSO 2132 01:30:39,760 --> 01:30:40,200 PARTICIPATED. 2133 01:30:40,200 --> 01:30:43,760 WE WERE ASKED TO REVIEW THE 2134 01:30:43,760 --> 01:30:47,160 OVERALL RESEARCH GOALS AND 2135 01:30:47,160 --> 01:30:50,160 PROVIDE SUGGESTIONS ON 2136 01:30:50,160 --> 01:30:52,400 DIRECTIONS AND EVERYONE SEIZE 2137 01:30:52,400 --> 01:30:53,200 GOING FORWARD. 2138 01:30:53,200 --> 01:30:55,920 THE GOALS ARE LIFTED HERE, 2139 01:30:55,920 --> 01:30:57,680 OVERALL GOALS, CONTRACT RAISE 2140 01:30:57,680 --> 01:30:59,400 FACTORS IN OLDER PERSONS THAT 2141 01:30:59,400 --> 01:31:03,440 INFLUENCE RISK AND SEVERITY OF 2142 01:31:03,440 --> 01:31:04,280 MORBIDITIES, DISABILITIES, 2143 01:31:04,280 --> 01:31:05,480 SYMPTOMS, VULNERABILITY TO 2144 01:31:05,480 --> 01:31:08,400 STRESSORS, THIS IS THE PURVIEW 2145 01:31:08,400 --> 01:31:12,160 OF THE GERIATRICS BRANCH. 2146 01:31:12,160 --> 01:31:14,320 THE CLINICAL GERONTOLOGY 2147 01:31:14,320 --> 01:31:15,800 BRANCH LOOKS AT CHARACTERIZE 2148 01:31:15,800 --> 01:31:18,120 FACTORS THAT INFLUENCE CHANGES 2149 01:31:18,120 --> 01:31:19,840 OVER THE LIFESPAN AFFECTING 2150 01:31:19,840 --> 01:31:22,960 HEALTH SPAN AND LONGEVITY AND 2151 01:31:22,960 --> 01:31:24,600 THE CLINICAL TRIALS BRANCH 2152 01:31:24,600 --> 01:31:26,440 LOOKS AT DEVELOPING AND 2153 01:31:26,440 --> 01:31:29,600 TESTING INTERVENTIONS TO TREAT 2154 01:31:29,600 --> 01:31:30,880 OR PREVENT AGE-RELATED 2155 01:31:30,880 --> 01:31:32,960 CONDITIONS AND EXTEND HEALTHY 2156 01:31:32,960 --> 01:31:33,920 LIFESPAN. 2157 01:31:33,920 --> 01:31:35,760 THE GROUP WAS ALSO ASKED TO 2158 01:31:35,760 --> 01:31:37,720 IMPROVE PIPELINES FOR 2159 01:31:37,720 --> 01:31:38,800 DEVELOPING NEW INTERVENTIONS 2160 01:31:38,800 --> 01:31:42,880 THAT MERIT TESTING IN CLINICAL 2161 01:31:42,880 --> 01:31:44,600 TRIALS AND TO ACHIEVE 2162 01:31:44,600 --> 01:31:49,320 SUFFICIENT RESEARCH POPULATION 2163 01:31:49,320 --> 01:31:50,440 DIVERSITY TO ADDRESS CAUSES 2164 01:31:50,440 --> 01:31:52,080 AND EFFECTS OF 2165 01:31:52,080 --> 01:31:53,640 DIVERSITY-RELATED FACTORS AND 2166 01:31:53,640 --> 01:31:58,720 ON ITS OWN THE COMMITTEE CHOSE 2167 01:31:58,720 --> 01:32:01,280 TO ALSO INCLUDE WORKFORCE 2168 01:32:01,280 --> 01:32:02,080 DIVERSITY BECAUSE IT 2169 01:32:02,080 --> 01:32:03,480 INTERSECTS WITH MANY THINGS WE 2170 01:32:03,480 --> 01:32:04,600 HAVE JUST HEARD AND THE 2171 01:32:04,600 --> 01:32:05,720 COMMITTEE WANTED TO DISCUSS IT 2172 01:32:05,720 --> 01:32:06,280 FURTHER. 2173 01:32:06,280 --> 01:32:11,200 THIS IS A SCHEMATIC OF HOW THE 2174 01:32:11,200 --> 01:32:14,280 DIVISION THEN ALLOCATES ITS 2175 01:32:14,280 --> 01:32:14,760 RESOURCES. 2176 01:32:14,760 --> 01:32:17,720 OF I WOULD MOSTLY POINT AT THE 2177 01:32:17,720 --> 01:32:20,000 AWARDS, UPPER RIGHT, MOST OF 2178 01:32:20,000 --> 01:32:25,840 THE AWARDS ARE IN THE 2179 01:32:25,840 --> 01:32:29,360 GERIATRICS BRANCH IN 2180 01:32:29,360 --> 01:32:31,200 GERONTOLOGY AND CLINICAL 2181 01:32:31,200 --> 01:32:32,160 TRIALS, REFLECTS WHERE THE 2182 01:32:32,160 --> 01:32:35,960 NEED IS BUT ALSO THE KINDS OF 2183 01:32:35,960 --> 01:32:36,760 GRANTS COMING IN. 2184 01:32:36,760 --> 01:32:37,800 ABOUT 9 PERCENT OF THE BUDGET 2185 01:32:37,800 --> 01:32:39,840 GOES TO THE TRAINING AND YOU 2186 01:32:39,840 --> 01:32:42,640 CAN SEE ABOUT HALF MILLION 2187 01:32:42,640 --> 01:32:48,120 DOLLARS IN DIVERSITY 2188 01:32:48,120 --> 01:32:48,520 SUPPLEMENTS. 2189 01:32:48,520 --> 01:32:52,760 SO A FEW INITIAL REMARKS, I 2190 01:32:52,760 --> 01:32:54,320 WANTED TO JUST CONGRATULATE 2191 01:32:54,320 --> 01:32:57,240 THE DIVISION ON THEIR LAST 2192 01:32:57,240 --> 01:32:58,880 REVIEW, I THINK IT WAS SEVERAL 2193 01:32:58,880 --> 01:33:01,680 YEARS AGO, TO LIMIT THE AMOUNT 2194 01:33:01,680 --> 01:33:06,040 OF WORK DONE OVER THAT 2195 01:33:06,040 --> 01:33:07,000 INTERVAL, TREMENDOUS 2196 01:33:07,000 --> 01:33:08,320 ACHIEVEMENT, AND ALSO WANTED 2197 01:33:08,320 --> 01:33:15,040 TO JUST THANK THE DIVISION 2198 01:33:15,040 --> 01:33:20,400 LEADERS, THE BRANCH CHIEF 2199 01:33:20,400 --> 01:33:22,840 HADLEY AND OTHERS BEING 2200 01:33:22,840 --> 01:33:23,600 INCREDIBLY HELP HELPFUL. 2201 01:33:23,600 --> 01:33:26,320 THE COMMITTEE WAS PROVIDED 2202 01:33:26,320 --> 01:33:27,320 WITH VERY PERTINENT MATERIALS 2203 01:33:27,320 --> 01:33:28,640 THAT CERTAINLY HELPED US IN 2204 01:33:28,640 --> 01:33:29,800 OUR JOB. 2205 01:33:29,800 --> 01:33:31,680 THE COMMITTEE WAS REALLY 2206 01:33:31,680 --> 01:33:34,160 IMPRESSED BOTH BY THE URGENCY 2207 01:33:34,160 --> 01:33:36,880 AND SCOPE OF THE MISSION. 2208 01:33:36,880 --> 01:33:38,920 THE URGENCY, IF YOU LOOK WHEN 2209 01:33:38,920 --> 01:33:42,600 THE PREVIOUS REVIEW WAS 2210 01:33:42,600 --> 01:33:51,440 COMPLETED WHICH WAS 2015 TO 2211 01:33:51,440 --> 01:33:53,680 SEVEN YEAR PERIOD, TO 2030, 2212 01:33:53,680 --> 01:34:01,600 THE OLDER PERSON IN THE -- 2213 01:34:01,600 --> 01:34:05,560 PERSONS IN THE UNITED STATES 2214 01:34:05,560 --> 01:34:06,520 WILL INCREASE 30 PERCENT SO 2215 01:34:06,520 --> 01:34:09,200 THE MISSION IS VERY URGENT AND 2216 01:34:09,200 --> 01:34:12,280 WE'RE ALSO IMPRESSED BY THE 2217 01:34:12,280 --> 01:34:16,960 SCOPE, FULLY TRANSLATIONAL AND 2218 01:34:16,960 --> 01:34:17,640 QUITE COMPREHENSIVE AND THAT 2219 01:34:17,640 --> 01:34:19,400 IS ALSO A CHALLENGE WE WILL 2220 01:34:19,400 --> 01:34:20,840 TALK ABOUT AND I WOULD ALSO 2221 01:34:20,840 --> 01:34:23,240 LIKE TO THANK THE OTHER 2222 01:34:23,240 --> 01:34:24,360 COMMITTEE MOMENTS, VERY 2223 01:34:24,360 --> 01:34:24,680 ENGAGED. 2224 01:34:24,680 --> 01:34:26,880 WE HAVE A LARGE NUMBER OF 2225 01:34:26,880 --> 01:34:27,480 SUGGESTIONS AND 2226 01:34:27,480 --> 01:34:28,360 RECOMMENDATIONS AND I WILL 2227 01:34:28,360 --> 01:34:32,120 COVER THE HIGHLIGHTS IN THIS 2228 01:34:32,120 --> 01:34:32,800 REVIEW. 2229 01:34:32,800 --> 01:34:38,120 SO SOME BROADER STRATEGIC 2230 01:34:38,120 --> 01:34:38,800 RECOMMENDATIONS. 2231 01:34:38,800 --> 01:34:42,760 THE DIVISION HAS AN UNUSUAL 2232 01:34:42,760 --> 01:34:44,720 PLACE TO PROMOTE HEALTH SYSTEM 2233 01:34:44,720 --> 01:34:45,640 AND IMPLEMENTATION FOCUS 2234 01:34:45,640 --> 01:34:46,800 RESEARCH, I WILL TALK ABOUT 2235 01:34:46,800 --> 01:34:48,560 THAT IN A SECOND. 2236 01:34:48,560 --> 01:34:51,840 THE NUMBER OF CONCERNS AND 2237 01:34:51,840 --> 01:34:54,920 ISSUES AND OPPORTUNITIES IN 2238 01:34:54,920 --> 01:34:57,280 THE CLINICAL TRIALS SPACE AND 2239 01:34:57,280 --> 01:34:59,600 WE HAVE A SUGGESTION WHICH I 2240 01:34:59,600 --> 01:35:05,040 WILL ALSO ELABORATE ON IN THE 2241 01:35:05,040 --> 01:35:08,120 DEVELOPMENTA L SECTION OF THE 2242 01:35:08,120 --> 01:35:10,640 CLINICAL TRIAL NETWORK. 2243 01:35:10,640 --> 01:35:15,360 ONE OF THE THIRD PIPELINES WAS 2244 01:35:15,360 --> 01:35:16,200 QUICKLY DEVELOPED ON THE 2245 01:35:16,200 --> 01:35:17,480 BIOLOGY OF AGING AND AN 2246 01:35:17,480 --> 01:35:19,240 IMPORTANT NEED TO PUT THOSE 2247 01:35:19,240 --> 01:35:22,040 INSIGHTS TO WORK IN A 2248 01:35:22,040 --> 01:35:22,960 TRANSLATIONAL WAY. 2249 01:35:22,960 --> 01:35:30,120 AND WE ALSO ARE VERY COGNIZANT 2250 01:35:30,120 --> 01:35:32,440 OF THE PROBLEMS OF HEALTH 2251 01:35:32,440 --> 01:35:35,480 DISPARITIES AND AGING AND 2252 01:35:35,480 --> 01:35:37,920 REALLY UNDERSTAND THAT YOU 2253 01:35:37,920 --> 01:35:40,040 CAN'T REALLY MAKE ANY 2254 01:35:40,040 --> 01:35:42,920 ADVANCEMENT IN THOSE AREAS 2255 01:35:42,920 --> 01:35:47,040 UNTIL YOU ALSO INCLUDE IN YOUR 2256 01:35:47,040 --> 01:35:51,360 THEORETICAL AND CENTRAL MODELS 2257 01:35:51,360 --> 01:35:54,320 SOCIAL DETERMINANCES AND 2258 01:35:54,320 --> 01:35:54,920 STRUCTURAL DETERMINANTS. 2259 01:35:54,920 --> 01:35:56,600 AND FINALLY GIVEN THIS VERY 2260 01:35:56,600 --> 01:35:59,240 BROAD MISSION, COLLABORATIONS 2261 01:35:59,240 --> 01:36:01,040 ARE CRITICAL AND WITH THE 2262 01:36:01,040 --> 01:36:07,880 OTHER DIVISIONS WITHIN NIA, 2263 01:36:07,880 --> 01:36:10,200 PHARMA, PCORI, FDA AND OTHER 2264 01:36:10,200 --> 01:36:10,520 ICS. 2265 01:36:10,520 --> 01:36:12,000 THE MISSION IS BROAD ENOUGH 2266 01:36:12,000 --> 01:36:15,680 THAT NO AMOUNT OF MONEY, IT IS 2267 01:36:15,680 --> 01:36:16,520 ALMOST INEXHAUSTIBLE RESOURCES 2268 01:36:16,520 --> 01:36:18,600 SO THE WAY TO MAKE 2269 01:36:18,600 --> 01:36:20,680 ACHIEVEMENTS FOR ADVANCES ARE 2270 01:36:20,680 --> 01:36:23,360 IN ALLIANCE AND PROVIDING 2271 01:36:23,360 --> 01:36:26,480 CATALYTIC SUPPORT IN 2272 01:36:26,480 --> 01:36:31,280 COMBINATION WITH OTHER 2273 01:36:31,280 --> 01:36:32,400 PARTNERS AND STAKEHOLDERS. 2274 01:36:32,400 --> 01:36:36,400 WITH THAT SAID, LOOKED AT EACH 2275 01:36:36,400 --> 01:36:37,160 BRANCH. 2276 01:36:37,160 --> 01:36:40,240 THE MAJOR RECOMMENDATION FOR 2277 01:36:40,240 --> 01:36:43,680 THE GERIATRICS BRINGCH WAS TO 2278 01:36:43,680 --> 01:36:46,400 CONSIDER TWO SUBBRANCHES, 2279 01:36:46,400 --> 01:36:49,400 WHETHER STRUCTURAL OR 2280 01:36:49,400 --> 01:36:51,280 CONCEPTUALLY, ONE FOCUSING ON 2281 01:36:51,280 --> 01:36:53,560 BASIC, CLINICAL AND 2282 01:36:53,560 --> 01:36:54,440 TRANSLATIONAL RES 2283 01:36:54,440 --> 01:36:57,360 A LARGE AMOUNT OF GERIATRIC 2284 01:36:57,360 --> 01:36:58,600 WORKFORCE IS ACTUALLY 2285 01:36:58,600 --> 01:37:00,200 INTERESTED OR DEVOTING THEIR 2286 01:37:00,200 --> 01:37:02,400 TRAINING TO ITEM 2 WHICH IS 2287 01:37:02,400 --> 01:37:06,680 HEALTHCARE RESEARCH WHICH 2288 01:37:06,680 --> 01:37:07,680 FOCUSES ON DIAGNOSTICS, 2289 01:37:07,680 --> 01:37:10,040 PROPRIATE USESEF 2290 01:37:10,040 --> 01:37:10,800 INTERVENTION, INNOVATION AND 2291 01:37:10,800 --> 01:37:12,600 CARE CENTERS ANDUSING 2292 01:37:12,600 --> 01:37:14,080 ON CARE DELIVERED AT SITES 2293 01:37:14,080 --> 01:37:18,520 WHERE OLDER PERSONS LIVE OR 2294 01:37:18,520 --> 01:37:20,920 RECEIVE CARE. 2295 01:37:20,920 --> 01:37:23,720 IT IS INCREASINGLY IMPORTANT 2296 01:37:23,720 --> 01:37:28,400 AT NIH IN A RESOURCE STARVED 2297 01:37:28,400 --> 01:37:30,360 ENVIRONMENT TO DID BETTER JOBS 2298 01:37:30,360 --> 01:37:31,400 DELIVERING CARE AND THIS IS 2299 01:37:31,400 --> 01:37:33,800 VERY IMPORTANT FOR OUR 2300 01:37:33,800 --> 01:37:34,160 MISSION. 2301 01:37:34,160 --> 01:37:36,600 WE ENCOURAGE THE DIVISION WORK 2302 01:37:36,600 --> 01:37:39,440 CLOSELY WITH THE DIVISION OF 2303 01:37:39,440 --> 01:37:40,720 NEUROLOGY, INCREASE SUPPORT 2304 01:37:40,720 --> 01:37:43,840 FOR WORKING IN MEDICAL 2305 01:37:43,840 --> 01:37:46,400 MANAGEMENT FOR THOSE WITH ADRD 2306 01:37:46,400 --> 01:37:49,520 AND ONE OF THE PROGRAMS, THIS 2307 01:37:49,520 --> 01:37:51,920 BRANCH OVERSEAS IS THE PEPPER 2308 01:37:51,920 --> 01:37:52,440 PROGRAM. 2309 01:37:52,440 --> 01:37:54,240 THE COMMITTEE WAS VERY LAUD 2310 01:37:54,240 --> 01:37:59,760 TORE ON THIS AND GIVEN THE 2311 01:37:59,760 --> 01:38:01,720 URGE DEPENDS SEE OF WHAT CAN 2312 01:38:01,720 --> 01:38:03,360 BE DONE TO INCREASE THE NUMBER 2313 01:38:03,360 --> 01:38:04,840 OF CENTERS AND FUNDING PER 2314 01:38:04,840 --> 01:38:06,400 CENTER. 2315 01:38:06,400 --> 01:38:08,480 FOR THE CLINICAL GENUINE TOLGS 2316 01:38:08,480 --> 01:38:11,680 BRANCH, THE COMMUNITY REALLY 2317 01:38:11,680 --> 01:38:16,040 EMPHASIZED THE IMPORTANCE OF 2318 01:38:16,040 --> 01:38:18,880 LONGITUDINAL STUDIES, STUDIES 2319 01:38:18,880 --> 01:38:22,160 OF PEOPLE AIFFERENT AGES, A 2320 01:38:22,160 --> 01:38:24,400 LOT OF STUDY HAS BEEN DONE TO 2321 01:38:24,400 --> 01:38:26,240 MAKE ADVANCESKETHIS AREA. 2322 01:38:26,240 --> 01:38:28,680 WITHIN THE NIH, THERE ARE 2323 01:38:28,680 --> 01:38:30,600 ONGOING STUDIES, MANY 2324 01:38:30,600 --> 01:38:32,120 INITIATED BY OTHER INSTITUTES, 2325 01:38:32,120 --> 01:38:33,760 A COMMITTEE THOUGHT A 2326 01:38:33,760 --> 01:38:37,800 STRATEGIC REVIEW OF THAT 2327 01:38:37,800 --> 01:38:42,400 SUPP IF THERE IS 2328 01:38:42,400 --> 01:38:47,640 AVERAGE DIVERSITY ACROSS THE 2329 01:38:47,640 --> 01:38:50,680 LIFE COURSE, AND NEW ASSAYS 2330 01:38:50,680 --> 01:38:53,680 AND STUDY DESIGNS OR 2331 01:38:53,680 --> 01:38:54,720 ANALYTICAL METHODS SHOULD BE 2332 01:38:54,720 --> 01:38:57,280 CONSIDERED TO SEE IF NEW 2333 01:38:57,280 --> 01:38:59,400 STUDIES SHOULD BE STARTED UP 2334 01:38:59,400 --> 01:39:01,640 TO ENSURE THERE IS ADEQUATE 2335 01:39:01,640 --> 01:39:02,760 COVERAGE ACROSS ALL THE AREAS 2336 01:39:02,760 --> 01:39:13,280 THAT WOULD BE PERTINENT. 2337 01:39:16,960 --> 01:39:18,360 THIS DIVISION WORK SHOWS THAT 2338 01:39:18,360 --> 01:39:21,760 SCALE IS VERY IMPORTANT. 2339 01:39:21,760 --> 01:39:27,080 THE SIGNALS TEND TO BE VERY 2340 01:39:27,080 --> 01:39:31,920 FAINT AND SOME PARTNERSHIPS OR 2341 01:39:31,920 --> 01:39:33,400 COORDINATION ARE NECESSARY TO 2342 01:39:33,400 --> 01:39:34,800 ACHIEVE IT BECAUSE THEY MAY 2343 01:39:34,800 --> 01:39:36,920 NOT HAVE THE RESOURCES TO DO 2344 01:39:36,920 --> 01:39:39,280 IT ON THEIR OWN. 2345 01:39:39,280 --> 01:39:41,960 COMMITTEE VERY INTERESTED INN S 2346 01:39:41,960 --> 01:39:43,800 TARGETING THE BIOLOGY OF 2347 01:39:43,800 --> 01:39:44,160 AGING. 2348 01:39:44,160 --> 01:39:46,440 NEED TO SUPPORT PHASE 2 AND 3 2349 01:39:46,440 --> 01:39:47,760 TRIALS AND WE'LL TALK ABOUT 2350 01:39:47,760 --> 01:39:49,480 THE NETWORK IN A BIT. 2351 01:39:49,480 --> 01:39:52,200 OPPORTUNITIES FOR A LOT OF 2352 01:39:52,200 --> 01:39:53,920 PRECOMPETITIVE PROGRAMS WITH 2353 01:39:53,920 --> 01:39:54,240 PHARMA. 2354 01:39:54,240 --> 01:39:57,960 S A LOT OF WORK IN 2355 01:39:57,960 --> 01:39:59,840 PHARMA IN THE BIOMARKER SPACE 2356 01:39:59,840 --> 01:40:08,040 THAT COULD BE VERY HELPFUL TO 2357 01:40:08,040 --> 01:40:09,120 OTHER INVESTIGATORS AND ALSO 2358 01:40:09,120 --> 01:40:11,440 IMPORTANT TO PARTNER WITH NIA 2359 01:40:11,440 --> 01:40:15,360 AND NIH TO JOINTLY SUPPORT 2360 01:40:15,360 --> 01:40:20,360 RFA'S FOR EARLY DRUG SCREENING 2361 01:40:20,360 --> 01:40:27,000 AND ASSAY DEVELOPMENT. 2362 01:40:27,000 --> 01:40:30,920 THE BRANCH SUPPORTS THE 2363 01:40:30,920 --> 01:40:35,520 BIOBANK, A RELATIVELY NEW 2364 01:40:35,520 --> 01:40:39,960 RESOURCE, THE NIH COLLECTED 2365 01:40:39,960 --> 01:40:44,640 STUDIES AND SPECIMENS TO BE 2366 01:40:44,640 --> 01:40:46,360 DEPOSITED IN A BIOBANK TO 2367 01:40:46,360 --> 01:40:49,120 ALLOW OTHER PEOPLE TO USE THAT 2368 01:40:49,120 --> 01:40:50,560 IN THEIR DISCOVERY SCIENCE OR 2369 01:40:50,560 --> 01:40:54,120 AS A SOURCE OF SAMPLES FOR 2370 01:40:54,120 --> 01:40:56,760 THEIR RESEARCH IS VERY 2371 01:40:56,760 --> 01:40:58,520 PROMISING AND ENCOURAGE 2372 01:40:58,520 --> 01:40:59,000 DEVELOPMENT. 2373 01:40:59,000 --> 01:41:00,600 CURRENTLY MORE SOCIALIZATION 2374 01:41:00,600 --> 01:41:07,880 TO THE WORLD THAN WHAT IT IS 2375 01:41:07,880 --> 01:41:10,760 NOW AND HOW IT MIGHT BE USED 2376 01:41:10,760 --> 01:41:12,520 IS RECOMMENDED AND AS PEOPLE 2377 01:41:12,520 --> 01:41:15,720 THINK ABOUT IT, WILL BE A VERY 2378 01:41:15,720 --> 01:41:17,400 WELL USED RESOURCE. 2379 01:41:17,400 --> 01:41:18,040 SPECIFIC AREAS WARRANTING 2380 01:41:18,040 --> 01:41:19,320 ATTENTION AND I WANT TO 2381 01:41:19,320 --> 01:41:20,760 EMPHASIZE THESE THINGS THAT I 2382 01:41:20,760 --> 01:41:22,560 AM SAYING AREN'T JUST THAT THE 2383 01:41:22,560 --> 01:41:23,800 DIVISION DOESN'T DO THEM BUT 2384 01:41:23,800 --> 01:41:25,280 THAT THESE ARE -- AND WITH ALL 2385 01:41:25,280 --> 01:41:28,760 THE THINGS I AM SAYING BUT IT 2386 01:41:28,760 --> 01:41:35,400 JUST SEEM OF PARTICULAR 2387 01:41:35,400 --> 01:41:36,240 SALIENT -- SEEM PARTICULARLY 2388 01:41:36,240 --> 01:41:37,080 SALIENT TO THE COMMUNITY. 2389 01:41:37,080 --> 01:41:40,200 A LOT OF WORK IN OBESITY IN 2390 01:41:40,200 --> 01:41:45,360 ADULTS AND ITS TREATMENT AND 2391 01:41:45,360 --> 01:41:49,280 BEYOND FOOD IN AND FOOD OUT 2392 01:41:49,280 --> 01:41:51,000 DIETARY PATTERNS. 2393 01:41:51,000 --> 01:41:53,760 THE EPIDEMIOLOGY AND DIETARY 2394 01:41:53,760 --> 01:41:55,960 PATTERNS ARE IMPORTANT FOR 2395 01:41:55,960 --> 01:41:57,640 HEALTH OUTCOME AND PERSISTENT 2396 01:41:57,640 --> 01:41:59,200 AND THE IMPORTANCE OF FOLLOW 2397 01:41:59,200 --> 01:41:59,640 UP WITH THAT. 2398 01:41:59,640 --> 01:42:06,560 A LOT OF USING IPSC'S AND 2399 01:42:06,560 --> 01:42:08,480 LAB-ON-A-CHIP TECHNOLOGY TO 2400 01:42:08,480 --> 01:42:09,520 EXPLORE AGING SYSTEM AND 2401 01:42:09,520 --> 01:42:12,360 BIOLOGY AT THAT LEVEL AND 2402 01:42:12,360 --> 01:42:15,080 AGAIN, THE RESOURCE ABOUT 2403 01:42:15,080 --> 01:42:16,920 BIOMARKERS, THESE ARE TWO 2404 01:42:16,920 --> 01:42:18,360 AREAS THE TWIGS COULD WORK 2405 01:42:18,360 --> 01:42:24,960 WELL WITH THE DIVISION -- THE 2406 01:42:24,960 --> 01:42:26,400 DIVISION COULD WORK WELL WITH 2407 01:42:26,400 --> 01:42:27,320 THE DIVISION TO EXPLORE. 2408 01:42:27,320 --> 01:42:29,240 AND THERE IS AN OPPORTUNITY TO 2409 01:42:29,240 --> 01:42:30,960 HAVE MORE IMPORTANCE ON THE 2410 01:42:30,960 --> 01:42:32,920 IMMUNE SYSTEM FROM THREE 2411 01:42:32,920 --> 01:42:35,360 VARIOUS ASPECTS. 2412 01:42:35,360 --> 01:42:40,240 ONE IS AGING PER SE AND IN A 2413 01:42:40,240 --> 01:42:42,240 TRANSLATIONAL WORLD, SERVES AN 2414 01:42:42,240 --> 01:42:45,080 IMPORTANT ROLE ON ORGANISMAL 2415 01:42:45,080 --> 01:42:46,880 AGING AND AS A RESPONSE TARGET 2416 01:42:46,880 --> 01:42:48,400 TO INTERVENTION AS WELL. 2417 01:42:48,400 --> 01:42:52,080 SO A LOT OF OPPORTUNITIES TO 2418 01:42:52,080 --> 01:42:57,720 INCREASE THE SCIENCE IN THAT 2419 01:42:57,720 --> 01:42:58,160 AREA. 2420 01:42:58,160 --> 01:43:00,160 SO IN TALKING ABOUT THE 2421 01:43:00,160 --> 01:43:02,000 CLINICAL TRIALS BRANCH, WE 2422 01:43:02,000 --> 01:43:03,520 REALLY FOCUSED ON IMPROVING 2423 01:43:03,520 --> 01:43:06,160 THE PIPELINE FOR DEVELOPING 2424 01:43:06,160 --> 01:43:08,440 NEW INTERVENTIONS BECAUSE WE 2425 01:43:08,440 --> 01:43:09,640 SORT OF INCORPORATED A LOT OF 2426 01:43:09,640 --> 01:43:13,880 THE MISSION OF THE BRANCH IN 2427 01:43:13,880 --> 01:43:17,040 THIS ONE REQUEST. 2428 01:43:17,040 --> 01:43:18,680 WE THOUGHT ABOUT THE POOL OF 2429 01:43:18,680 --> 01:43:19,600 INVESTIGATORS AND THE 2430 01:43:19,600 --> 01:43:20,480 COMMITTEE IS CONCERNED THAT 2431 01:43:20,480 --> 01:43:24,320 THE POOL IS SMALL AND LACKS 2432 01:43:24,320 --> 01:43:25,040 DIVERSITY AND EXPERTISE. 2433 01:43:25,040 --> 01:43:29,840 IF YOU LOOK AT ALL OF THE 2434 01:43:29,840 --> 01:43:32,080 PEOPLE WITH DECENT AWARDS THAT 2435 01:43:32,080 --> 01:43:33,720 THE NIH CURRENTLY FUNDS, VERY, 2436 01:43:33,720 --> 01:43:35,840 VERY FEW OF THEM ARE DOING 2437 01:43:35,840 --> 01:43:43,440 ANYTHING THAT IS RELEVANT TO 2438 01:43:43,440 --> 01:43:47,160 THIS AREA. 2439 01:43:47,160 --> 01:43:49,080 THERE IS ALSO MOTIVATION TO 2440 01:43:49,080 --> 01:43:51,640 DEVELOP TRIALS AND DECIDING 2441 01:43:51,640 --> 01:43:52,800 WHICH INTERVENTIONS, MERIT 2442 01:43:52,800 --> 01:43:56,080 TESTING IS A GREAT AREA FOR 2443 01:43:56,080 --> 01:43:58,400 COLLABORATION ACROSS THE 2444 01:43:58,400 --> 01:44:05,320 INSTITUTE AND WITH PHARMA AND 2445 01:44:05,320 --> 01:44:06,080 CMS. 2446 01:44:06,080 --> 01:44:08,600 SO WE SUGGEST DEVELOPING A 2447 01:44:08,600 --> 01:44:12,040 CLINICAL TRIAL PLATFORM WITH A 2448 01:44:12,040 --> 01:44:13,520 COORDINATING CENTER AND 2449 01:44:13,520 --> 01:44:14,720 AFFILIATED CENTER AND WANTED 2450 01:44:14,720 --> 01:44:16,640 TO MOSTLY POINT OUT THE 2451 01:44:16,640 --> 01:44:18,800 BENEFITS OF THIS OR EFFICIENCY 2452 01:44:18,800 --> 01:44:21,240 GAINS BECAUSE THERE ARE FIXED 2453 01:44:21,240 --> 01:44:22,440 COSTS IN ADMINISTRATION THAT 2454 01:44:22,440 --> 01:44:33,040 COULD BE SPREAD ACROSS TRIALS, 2455 01:44:33,920 --> 01:44:38,960 HAVING RFAS COULD EFFICIENTLY 2456 01:44:38,960 --> 01:44:40,040 ADDRESS DIVISION PRIORITIES. 2457 01:44:40,040 --> 01:44:43,360 RECOMMENDATIONS HAVE TO DO 2458 01:44:43,360 --> 01:44:45,520 WITH OVERSIGHT MODELS THAT 2459 01:44:45,520 --> 01:44:47,480 MIGHT BE EXAMINED IN OTHER 2460 01:44:47,480 --> 01:44:50,720 INSTITUTES THAT ARE PHASEDSE 2461 01:44:50,720 --> 01:44:52,680 PROVIDE SOME CONTROL AND 2462 01:44:52,680 --> 01:44:59,480 ABILITY TO DIVERT -- TO FOCUS 2463 01:44:59,480 --> 01:45:02,440 RESOURCES ON SUCCESSFUL TRIALS 2464 01:45:02,440 --> 01:45:04,040 AND PROMOTE INTERVENTIONS WITH 2465 01:45:04,040 --> 01:45:09,240 SPECIAL RELEVANCE. 2466 01:45:09,240 --> 01:45:13,560 THESE ARE MULTIMODAL 2467 01:45:13,560 --> 01:45:16,960 INTERVENTIONS WITH MULTIMODAL 2468 01:45:16,960 --> 01:45:23,600 INTERVENTIONSAND PROMOTING 2469 01:45:23,600 --> 01:45:24,240 PHARMACOTHERAPIES. 2470 01:45:24,240 --> 01:45:26,000 NOW I ACTUALLY DON'T NEED TO 2471 01:45:26,000 --> 01:45:27,640 SAY MUCH ABOUT THIS BECAUSE I 2472 01:45:27,640 --> 01:45:29,000 THOUGHT THE SECTION THAT CAME 2473 01:45:29,000 --> 01:45:30,760 FROM THE WORKING GROUP PRIOR 2474 01:45:30,760 --> 01:45:33,000 TO THIS MADE THESE POINTS ALL 2475 01:45:33,000 --> 01:45:35,080 VERY WELL SO I WANT TO 2476 01:45:35,080 --> 01:45:36,240 EMPHASIZE OUR COMMITTEE SAW 2477 01:45:36,240 --> 01:45:38,840 THIS ALL THE SAME WAY AND 2478 01:45:38,840 --> 01:45:40,200 AGREE THAT RESOURCES ARE 2479 01:45:40,200 --> 01:45:44,840 NEEDED TO BUILD THOSE TRUST 2480 01:45:44,840 --> 01:45:45,560 RELATIONSHIPS. 2481 01:45:45,560 --> 01:45:56,040 WITH RESPECT TO WORKFORCE, 2482 01:45:56,320 --> 01:45:57,960 PRETTY COMPREHENSIVE AND OUR 2483 01:45:57,960 --> 01:45:59,880 COMMITTEE AGREES WITH THEM BUT 2484 01:45:59,880 --> 01:46:01,040 THESE ARE STRATEGIES FOR 2485 01:46:01,040 --> 01:46:04,040 WORKING WITH PEOPLE EARLIER IN 2486 01:46:04,040 --> 01:46:06,680 THEIR CAREERS TO BRING 2487 01:46:06,680 --> 01:46:08,280 INTEREST TO AGING AND YOU CAN 2488 01:46:08,280 --> 01:46:10,520 READ FOR YOURSELF SOME OF 2489 01:46:10,520 --> 01:46:12,200 THESE STRATEGIES. 2490 01:46:12,200 --> 01:46:18,200 SO OUR WRITTEN REPORT IS IN 2491 01:46:18,200 --> 01:46:19,600 THE PENTULTIMATE VERSION. 2492 01:46:19,600 --> 01:46:22,840 WE WILL PRESENT THE FINAL 2493 01:46:22,840 --> 01:46:26,320 REPORT, I HOPE, TO Dr. HODES 2494 01:46:26,320 --> 01:46:30,640 ON MAY 31ST. 2495 01:46:30,640 --> 01:46:31,120 TH 2496 01:46:31,120 --> 01:46:31,640 . 2497 01:46:31,640 --> 01:46:35,840 >>STEVE, THANK YOU SO MUCH FO. 2498 01:46:35,840 --> 01:46:38,280 WE HAD -- AND WE REALLY 2499 01:46:38,280 --> 01:46:39,440 APPRECIATE THE TREMENDOUS 2500 01:46:39,440 --> 01:46:41,120 AMOUNT OF WORK THAT YOU AND 2501 01:46:41,120 --> 01:46:42,440 OTHER MEMBERS OF THE COMMITTEE 2502 01:46:42,440 --> 01:46:43,480 DID ON THIS REPORT. 2503 01:46:43,480 --> 01:46:46,680 WE HAD A VERY LIVELY AND 2504 01:46:46,680 --> 01:46:47,720 INSIGHTFUL DISCUSSION ABOUT 2505 01:46:47,720 --> 01:46:49,320 THIS YESTERDAY AND ARE LOOKING 2506 01:46:49,320 --> 01:46:50,640 FORWARD TO THE FINAL REPORT. 2507 01:46:50,640 --> 01:46:52,480 JUST WANT TO ASK IF THERE ARE 2508 01:46:52,480 --> 01:46:54,400 ANY OTHER THOUGHTS OR 2509 01:46:54,400 --> 01:46:57,200 QUESTIONS THAT THE 2510 01:46:57,200 --> 01:46:59,160 COMMITTEE -- THAT COUNCIL MAY 2511 01:46:59,160 --> 01:47:03,680 HAVE BEFORE WE CLOSE THIS 2512 01:47:03,680 --> 01:47:04,000 PART? 2513 01:47:04,000 --> 01:47:06,240 OKAY, SO IF NOT, THE FINAL 2514 01:47:06,240 --> 01:47:13,160 THING THAT THE WORKING GROUP 2515 01:47:13,160 --> 01:47:15,240 DISCUSSED WAS CFR'S 2516 01:47:15,240 --> 01:47:21,000 INITIATIVES TO STRENGTHEN PEER 2517 01:47:21,000 --> 01:47:22,280 REVIEW WITH Dr.S SPAN AND 2518 01:47:22,280 --> 01:47:24,680 YOU WANT TO SUMMARIZE THAT 2519 01:47:24,680 --> 01:47:25,480 CONVERSATION? 2520 01:47:25,480 --> 01:47:32,600 >>YES, SO WE HAD Dr. SPAN 2521 01:47:32,600 --> 01:47:35,280 GIVE US A TALK ON 2522 01:47:35,280 --> 01:47:36,240 STRENGTHENING PEER REVIEW. 2523 01:47:36,240 --> 01:47:38,080 SHE IS THE DIRECTOR OF THE 2524 01:47:38,080 --> 01:47:40,040 DIVISION OF NOURISH SCIENCE 2525 01:47:40,040 --> 01:47:42,440 AND AGING SCIENTIFIC REVIEW 2526 01:47:42,440 --> 01:47:44,640 AND IN HER PRESENTATION, SHE 2527 01:47:44,640 --> 01:47:46,600 FIRST STARTED OFF WITH GIVING 2528 01:47:46,600 --> 01:47:49,440 US SOME STATISTICS OF THE 2529 01:47:49,440 --> 01:47:53,520 SCOPE OF APPLICATIONS REVIEWED 2530 01:47:53,520 --> 01:47:57,720 AT CSR, DETAILING THAT THE NIH 2531 01:47:57,720 --> 01:47:59,480 RECEIVED APPROXIMATELY 79,000 2532 01:47:59,480 --> 01:48:02,320 APPLICATIONS EACH YEAR AND 2533 01:48:02,320 --> 01:48:06,480 THAT THE CSR REVIEWS 2534 01:48:06,480 --> 01:48:08,000 APPROXIMATELY 60,000 WHICH IS 2535 01:48:08,000 --> 01:48:08,960 76 PERCENT OF THOSE 2536 01:48:08,960 --> 01:48:09,400 APPLICATIONS. 2537 01:48:09,400 --> 01:48:17,320 THEY HAVE A STAFF OF 2775 SROS 2538 01:48:17,320 --> 01:48:21,000 WHICH LEAD TO 19,000 -- SORRY, 2539 01:48:21,000 --> 01:48:23,520 1200 MEETINGS PER YEAR 2540 01:48:23,520 --> 01:48:24,920 UTILIZING 19,000 REVIEWERS. 2541 01:48:24,920 --> 01:48:29,000 SO IN THE PRESENTATION, SHE 2542 01:48:29,000 --> 01:48:30,280 TALKED ABOUT FIVE DIFFERENT 2543 01:48:30,280 --> 01:48:33,360 WAYS IN WHICH THEY ARE TRYING 2544 01:48:33,360 --> 01:48:36,160 TO STEPBGTEN PEER REVIEW HERE 2545 01:48:36,160 --> 01:48:37,160 AT THE NIH. 2546 01:48:37,160 --> 01:48:40,800 THE FIRST POINT SHE MADE WAS 2547 01:48:40,800 --> 01:48:42,920 ABOUT THE EVALUATION PROCESS 2548 01:48:42,920 --> 01:48:47,600 THAT GOES ON IN CSR. 2549 01:48:47,600 --> 01:48:50,240 THIS PROCESS IS CALLED INQUIRE 2550 01:48:50,240 --> 01:48:54,440 WHICH STANDS FOR EVALUATING 2551 01:48:54,440 --> 01:48:58,920 PANEL QUALITY AND REVIEW. 2552 01:48:58,920 --> 01:49:01,120 THIS PANEL, IT DOES 2553 01:49:01,120 --> 01:49:03,120 APPROXIMATELY 20 PERCENT OF 2554 01:49:03,120 --> 01:49:05,440 THE DIFFERENT INITIATIVES EACH 2555 01:49:05,440 --> 01:49:08,400 YEAR THAT -- I'M SORRY, THE 2556 01:49:08,400 --> 01:49:12,000 STUDY SESSIONS THAT OCCUR IN 2557 01:49:12,000 --> 01:49:13,280 CSR EACH YEAR TO 2558 01:49:13,280 --> 01:49:14,440 APPROXIMATELY -- AND THEY 2559 01:49:14,440 --> 01:49:18,000 GROUP THESE ACCORDING TO 2560 01:49:18,000 --> 01:49:18,640 SCIENCE AREAS. 2561 01:49:18,640 --> 01:49:20,400 THIS PANEL DOES A THOROUGH 2562 01:49:20,400 --> 01:49:23,920 REVIEW AND IT GOES THROUGH 2563 01:49:23,920 --> 01:49:25,160 SEVERAL PROCESSES OF AAPPROVAL 2564 01:49:25,160 --> 01:49:29,320 AND PRESENTATION AT THEIR 2565 01:49:29,320 --> 01:49:31,880 COUNCIL TO GET THE GROUP OTHER 2566 01:49:31,880 --> 01:49:32,840 CHANGES OR RECOMMENDATIONS FOR 2567 01:49:32,840 --> 01:49:34,920 EACH OF THOSE STUDY SECTIONS. 2568 01:49:34,920 --> 01:49:39,520 SO APPROXIMATELY EVERY FOUR TO 2569 01:49:39,520 --> 01:49:41,760 FIVE YEARS, EVERY SECTION OR 2570 01:49:41,760 --> 01:49:43,760 CSR DOES GET REVIEWED. 2571 01:49:43,760 --> 01:49:46,520 NEXT THEY HAVE TALKED ABOUT 2572 01:49:46,520 --> 01:49:50,160 THE SIMPLIFYING THE PEER 2573 01:49:50,160 --> 01:49:51,040 REVIEW PROCESS. 2574 01:49:51,040 --> 01:49:54,040 IN THIS PRESENTATION, SHE 2575 01:49:54,040 --> 01:49:54,640 DISCUSSED THE HEALTH. 2576 01:49:54,640 --> 01:49:57,800 THEY ARE GOING TO BE CHANGING 2577 01:49:57,800 --> 01:50:00,400 THE REVIEW CRITERIA AND OUR 2578 01:50:00,400 --> 01:50:01,200 FUNDING OPPORTUNITY. 2579 01:50:01,200 --> 01:50:02,840 AS FETCH KNOWS RIGHT NOW THERE 2580 01:50:02,840 --> 01:50:07,360 ARE FIVE MAJOR REVIEW CRITERIA 2581 01:50:07,360 --> 01:50:09,720 SIGNIFICANT INNOVATION, 2582 01:50:09,720 --> 01:50:12,680 INVESTIGATORS APPROACH AND 2583 01:50:12,680 --> 01:50:14,160 ENVIRONMENT, SO RIGHT NOW THEY 2584 01:50:14,160 --> 01:50:17,880 ARE PROPOSING TO CHANGE THAT 2585 01:50:17,880 --> 01:50:21,400 INTO THREE DIFFERENT CRITERIA, 2586 01:50:21,400 --> 01:50:23,400 FIRST BEING IMPORTANCE OF THE 2587 01:50:23,400 --> 01:50:25,960 RESEARCH WHICH WOULD ENCOMPASS 2588 01:50:25,960 --> 01:50:27,680 SIGNIFICANCE IN INNOVATION. 2589 01:50:27,680 --> 01:50:29,280 SECOND BEING RIGOR AND 2590 01:50:29,280 --> 01:50:31,320 FEASIBILITY WHICH IS REALLY 2591 01:50:31,320 --> 01:50:35,240 THE APPROACH AND THEN FINALLY 2592 01:50:35,240 --> 01:50:37,480 EXPERTISE AND RESOURCES WHICH 2593 01:50:37,480 --> 01:50:39,920 WAS CURRENTLY THE INVESTIGATOR 2594 01:50:39,920 --> 01:50:41,800 ENVIRONMENT. 2595 01:50:41,800 --> 01:50:45,000 BUT THIS LAST ONE WILL NOT GET 2596 01:50:45,000 --> 01:50:47,600 A SECOND SCORE. 2597 01:50:47,600 --> 01:50:50,680 LIKE JUST GET INCORPORATED 2598 01:50:50,680 --> 01:50:53,400 INTO THE OVERALL FINAL IMPACT 2599 01:50:53,400 --> 01:50:57,800 SCORE FOR THE APPLICATION 2600 01:50:57,800 --> 01:50:58,680 ITSELF. 2601 01:50:58,680 --> 01:51:06,480 NEXT THEY DISCUSSED THE N NSRA 2602 01:51:06,480 --> 01:51:07,400 FELLOWSHIP. 2603 01:51:07,400 --> 01:51:08,520 THROUGH THEIR ANALYSIS THEY 2604 01:51:08,520 --> 01:51:10,520 DISCOVERED MOST OF THE 2605 01:51:10,520 --> 01:51:12,480 FELLOWSHIPS FELL WITHIN A VERY 2606 01:51:12,480 --> 01:51:13,560 SMALL SUBSET OF INSTITUTIONS 2607 01:51:13,560 --> 01:51:15,120 SO THEY WERE LOOKING TO 2608 01:51:15,120 --> 01:51:17,080 ADDRESS THIS SITUATION AND 2609 01:51:17,080 --> 01:51:20,120 HOPE TO REVISE THE 2610 01:51:20,120 --> 01:51:21,680 APPLICATIONS PROCESS AND THE 2611 01:51:21,680 --> 01:51:25,800 REVIEW CRITERIA OF THE FELLOW 2612 01:51:25,800 --> 01:51:26,840 SHIPS THEMSELVES. 2613 01:51:26,840 --> 01:51:30,360 NEXT THEY TALKED ABOUT 2614 01:51:30,360 --> 01:51:33,360 FAIRNESS IN REVIEW SO THEY -- 2615 01:51:33,360 --> 01:51:35,400 CSR HAS INSTITUTED TWO 2616 01:51:35,400 --> 01:51:38,560 TRAINING INITIATIVES FOR OUR 2617 01:51:38,560 --> 01:51:39,640 REVIEWER. 2618 01:51:39,640 --> 01:51:42,560 FIRST BEING BIAS AWARENESS. 2619 01:51:42,560 --> 01:51:44,600 THEY HAVE ALREADY HAD ABOUT 2620 01:51:44,600 --> 01:51:47,000 20,000 OF OUR REVIEWERS TAKE 2621 01:51:47,000 --> 01:51:49,680 THIS COURSE ALREADY AND IT HAS 2622 01:51:49,680 --> 01:51:51,680 BEEN WELL RECEIVED. 2623 01:51:51,680 --> 01:51:52,880 THE SECOND TRAINING MODULE 2624 01:51:52,880 --> 01:51:56,960 THAT THEY ARE INSTITUTING IS 2625 01:51:56,960 --> 01:51:59,480 ON INTEGRITY ALSO SO -- AND IT 2626 01:51:59,480 --> 01:52:01,360 IS BASED ON ACTUAL CASES THAT 2627 01:52:01,360 --> 01:52:04,000 HAVE BEEN PRESENTED TO THE 2628 01:52:04,000 --> 01:52:04,400 NIH. 2629 01:52:04,400 --> 01:52:07,120 AND SO THAT ALSO IS BEING 2630 01:52:07,120 --> 01:52:09,640 INCORPORATED INTO THE TRAINING 2631 01:52:09,640 --> 01:52:11,320 OF OUR REVIEW PANEL MEMBERS 2632 01:52:11,320 --> 01:52:14,240 AND THIS IS GOING TO BE 2633 01:52:14,240 --> 01:52:20,560 ENACTED BY MAY OF 2024. 2634 01:52:20,560 --> 01:52:23,440 FINALLY THEY ALSO TALKED ABOUT 2635 01:52:23,440 --> 01:52:25,560 DIVERSITY IN THE REVIEW PANEL 2636 01:52:25,560 --> 01:52:28,440 AND THEY GAVE US SOME 2637 01:52:28,440 --> 01:52:30,960 STATISTICS ABOUT HOW WE WOULD 2638 01:52:30,960 --> 01:52:32,600 INCREASE DIVERSITY IN OUR 2639 01:52:32,600 --> 01:52:32,960 PANEL. 2640 01:52:32,960 --> 01:52:38,960 WE ARE NOW IN THE PAST YEAR -- 2641 01:52:38,960 --> 01:52:41,160 THERE WAS -- WITH REGARDS TO 2642 01:52:41,160 --> 01:52:43,000 SENDER, 45 PERCENT OF THE 2643 01:52:43,000 --> 01:52:46,360 REVIEWERS ARE WOMEN AND 2644 01:52:46,360 --> 01:52:52,320 18 PERCENT ARE IN THE 2645 01:52:52,320 --> 01:52:53,280 UNDERREPRESENTED MINORITY 2646 01:52:53,280 --> 01:52:53,640 CATEGORY. 2647 01:52:53,640 --> 01:52:55,760 SO THERE ARE SEVERAL EFFORTS 2648 01:52:55,760 --> 01:52:58,600 BEING TAKEN BY CSR TO INCREASE 2649 01:52:58,600 --> 01:53:00,160 DIVERSITY IN OUR PANEL AND 2650 01:53:00,160 --> 01:53:01,320 THEY ARE CONTINUING THEIR 2651 01:53:01,320 --> 01:53:03,800 EFFORTS IN THIS AREA. 2652 01:53:03,800 --> 01:53:05,840 SO THAT'S BASICALLY THE 2653 01:53:05,840 --> 01:53:10,080 SUMMARY OF HER PRESENTATION. 2654 01:53:10,080 --> 01:53:11,200 >>THANK YOU, KEN. 2655 01:53:11,200 --> 01:53:13,040 ARE THERE THERE ANY OTHER 2656 01:53:13,040 --> 01:53:16,320 QUESTIONS OR CONCERNS ABOUT 2657 01:53:16,320 --> 01:53:17,160 THAT? 2658 01:53:17,160 --> 01:53:22,000 OKAY, IF NOT, THEN WE'RE 2659 01:53:22,000 --> 01:53:23,600 COMPLETED WITH THE PROGRAM. 2660 01:53:23,600 --> 01:53:26,400 >>GREAT, THANK YOU, SUSAN. 2661 01:53:26,400 --> 01:53:29,000 JUST A FEW MORE THINGS. 2662 01:53:29,000 --> 01:53:33,680 FIRST, I NEED TO CONSIDER THE 2663 01:53:33,680 --> 01:53:35,920 MINUTES FOR THE LAST COUNCIL 2664 01:53:35,920 --> 01:53:36,240 MEETING. 2665 01:53:36,240 --> 01:53:38,080 SO THE MINUTES FROM THE LAST 2666 01:53:38,080 --> 01:53:40,480 COUNCIL MEETING WITH POSTED IN 2667 01:53:40,480 --> 01:53:41,240 THE ELECTRONIC COUNCIL BOOK 2668 01:53:41,240 --> 01:53:43,680 AND I WOULD LIKE TO GET A 2669 01:53:43,680 --> 01:53:46,320 MOTION THEN TO APPROVE THE 2670 01:53:46,320 --> 01:53:48,760 MEETING FROM THE JANUARY 2023 2671 01:53:48,760 --> 01:53:49,120 COUNCIL. 2672 01:53:49,120 --> 01:53:51,400 IF I COULD GET A 2673 01:53:51,400 --> 01:53:52,880 RECOMMENDATION TO APPROVE? 2674 01:53:52,880 --> 01:53:54,720 >>SO MOVED. 2675 01:53:54,720 --> 01:53:58,280 >>AND A SECOND? 2676 01:53:58,280 --> 01:54:07,640 ALL IN FAVOR? 2677 01:54:07,640 --> 01:54:08,640 ANY OPPOSED? 2678 01:54:08,640 --> 01:54:09,040 [INAUDIBLE] 2679 01:54:09,040 --> 01:54:10,080 >>OH, YEAH, THAT IS OKAY BUT 2680 01:54:10,080 --> 01:54:11,480 THE MEETING MINUTES ARE IN FOR 2681 01:54:11,480 --> 01:54:12,640 YOUR INFORMATION BUT YOU DON'T 2682 01:54:12,640 --> 01:54:14,640 NEED TO VOTE AS A NEW MEMBER 2683 01:54:14,640 --> 01:54:20,480 TO THE COUNCIL, YEAH. 2684 01:54:20,480 --> 01:54:21,800 THANK YOU FOR THAT. 2685 01:54:21,800 --> 01:54:22,800 OKAY, THANK YOU VERY MUCH. 2686 01:54:22,800 --> 01:54:25,240 AND THEN JUST FOR FUTURE 2687 01:54:25,240 --> 01:54:26,360 MEETING DATES FOR COUNCIL, 2688 01:54:26,360 --> 01:54:30,080 JUST AS A REMINDER, OUR NEXT 2689 01:54:30,080 --> 01:54:31,440 COUNCIL MEETING IS IN 2690 01:54:31,440 --> 01:54:31,800 SEPTEMBER. 2691 01:54:31,800 --> 01:54:35,720 IT WILL BE TUESDAY, 2692 01:54:35,720 --> 01:54:38,520 SEPTEMBER 19TH AND WEDNESDAY, 2693 01:54:38,520 --> 01:54:39,160 SEPTEMBER 20TH. 2694 01:54:39,160 --> 01:54:43,680 ALSO HERE IN BUILDING 45, 2695 01:54:43,680 --> 01:54:44,840 NATCHER, IN-PERSON SO WE WILL 2696 01:54:44,840 --> 01:54:47,920 BE HAVING OUR NEXT MEETING 2697 01:54:47,920 --> 01:54:51,680 SEPTEMBER 19TH AND 20TH HERE 2698 01:54:51,680 --> 01:54:53,840 AND IN 2024, OUR MEETING 2699 01:54:53,840 --> 01:54:57,720 SCHEDULE IS AS YOU SEE UP 2700 01:54:57,720 --> 01:54:59,120 HERE, JANUARY 23RD AND 24TH 2701 01:54:59,120 --> 01:55:03,080 AND THAT WILL BE A VIRTUAL 2702 01:55:03,080 --> 01:55:03,440 NEATING. 2703 01:55:03,440 --> 01:55:05,840 WE HAVE DECIDED EARLIER ON 2704 01:55:05,840 --> 01:55:08,120 WHEN WE WENT BACK TO BEING 2705 01:55:08,120 --> 01:55:09,440 IN-PERSON MEETINGS THAT WE 2706 01:55:09,440 --> 01:55:11,360 WOULD HAVE TWO IN-PERSON 2707 01:55:11,360 --> 01:55:13,360 MEETINGS EACH YEAR AND ONE 2708 01:55:13,360 --> 01:55:19,400 VIRTUAL MEETING WHICH WOULD BE 2709 01:55:19,400 --> 01:55:21,000 IN OUR JANUARY -- AND THIS IS 2710 01:55:21,000 --> 01:55:23,440 MOSTLY BECAUSE OF THE 2711 01:55:23,440 --> 01:55:24,040 UNPREDICTABILITY OF THE 2712 01:55:24,040 --> 01:55:26,080 WEATHER SO THAT IS OUR JANUARY 2713 01:55:26,080 --> 01:55:27,240 MEETING AND THE MAY COUNCIL 2714 01:55:27,240 --> 01:55:31,640 NEXT YEAR IS MAY 22ND AND 21ST 2715 01:55:31,640 --> 01:55:32,880 HERE IN BUILDING 45 AND 2716 01:55:32,880 --> 01:55:35,120 FINALLY OUR SEPTEMBER COUNCIL 2717 01:55:35,120 --> 01:55:37,400 OF 2024 IS ON SEPTEMBER 18TH 2718 01:55:37,400 --> 01:55:40,480 AND 19TH AND THAT IS GOING TO 2719 01:55:40,480 --> 01:55:42,080 BE IN BUILDING 31. 2720 01:55:42,080 --> 01:55:44,720 SO THAT'S ALL FOR YOUR 2721 01:55:44,720 --> 01:55:45,320 INFORMATION. 2722 01:55:45,320 --> 01:55:47,800 SO AT THIS POINT, WE'RE GOING 2723 01:55:47,800 --> 01:55:50,800 TO TAKE A BREAK, A 15-MINUTE 2724 01:55:50,800 --> 01:55:52,560 BREAK AND THEN WE'RE GOING TO 2725 01:55:52,560 --> 01:55:55,400 COME BACK AND WE HAVE TWO 2726 01:55:55,400 --> 01:55:58,200 SPEAKERS FOR COUNCIL. 2727 01:55:58,200 --> 01:56:08,160 OUR FIRST SPEAKER IS Dr. 2728 01:56:08,160 --> 01:56:11,760 HONG-WEN DENG, TALKING ON 2729 01:56:11,760 --> 01:56:13,040 TRANS-OMICS STUDIES OF COMPLEX 2730 01:56:13,040 --> 01:56:15,600 AGING DISEASES AND THE NEXT 2731 01:56:15,600 --> 01:56:22,960 SPEAKER IS Dr. RICK WOYCHIK 2732 01:56:22,960 --> 01:56:25,960 FROM THE NATIONAL INSTITUTE OF 2733 01:56:25,960 --> 01:56:26,520 ENVIRONMENTAL HEALTH. 2734 01:56:26,520 --> 01:56:28,560 SO WE WILL HAVE THOSE AFTER 2735 01:56:28,560 --> 01:56:29,120 THE BREAK. 2736 01:56:29,120 --> 01:56:32,920 >>THANK EVERYONE FOR THE 2737 01:56:32,920 --> 01:56:33,840 FANTASTIC IN-PERSON MEETING, 2738 01:56:33,840 --> 01:56:35,240 APPRECIATE THE EFFORT YOU HAVE 2739 01:56:35,240 --> 01:56:38,280 MADE TO BE HERE AND WELCOME 2740 01:56:38,280 --> 01:56:41,160 ANY FEEDBACK IN OUR PLANS. 2741 01:56:41,160 --> 01:56:43,080 THE TWO OF THREE, PEOPLE 2742 01:56:43,080 --> 01:56:45,520 CUTTING BACK A LITTLE BIT ON 2743 01:56:45,520 --> 01:56:47,360 TRAVEL TO TAKE ADVANTAGE OF IN 2744 01:56:47,360 --> 01:56:49,400 PERSON BUT WELCOME ANY 2745 01:56:49,400 --> 01:56:50,920 COMMENTS NOW ABOUT HOW WE HAVE 2746 01:56:50,920 --> 01:56:51,480 DONE. 2747 01:56:51,480 --> 01:56:52,360 I KNOW FOR MYSELF IT HAS BEEN 2748 01:56:52,360 --> 01:56:55,160 EX SIDE OF THING TO SEE 2749 01:56:55,160 --> 01:56:56,440 EVERYONE AND HAVE INTERACTION 2750 01:56:56,440 --> 01:56:58,280 WITH REAL PERSONS BUT WE WILL 2751 01:56:58,280 --> 01:57:03,800 WELCOME YOUR RESPONSE TO OUR 2752 01:57:03,800 --> 01:57:04,560 PLAN. 2753 01:57:04,560 --> 01:57:07,240 >>I WOULD LIKE TO REITERATE 2754 01:57:07,240 --> 01:57:11,080 WHAT RICHARD JUST SAID TOO, IT 2755 01:57:11,080 --> 01:57:12,840 HAS BEEN REALLY GREAT TO HAVE 2756 01:57:12,840 --> 01:57:15,600 EVERYONE HERE AND SEE EVERYONE 2757 01:57:15,600 --> 01:57:15,880 REACT. 2758 01:57:15,880 --> 01:57:18,000 IT HAS BEEN MORE ENGAGING IN 2759 01:57:18,000 --> 01:57:19,600 OUR CONVERSATION AND JUST TO 2760 01:57:19,600 --> 01:57:23,080 SEE PEOPLE AFTER THREE YEARS 2761 01:57:23,080 --> 01:57:25,000 OF BEING COOPED UP IN OUR 2762 01:57:25,000 --> 01:57:26,840 OFFICES AND LOOKING AT ZOOM 2763 01:57:26,840 --> 01:57:28,960 FOR HOURS AND HOURS AND HOURS, 2764 01:57:28,960 --> 01:57:32,600 SO THIS HAS BEEN MUCH BETTER, 2765 01:57:32,600 --> 01:57:33,880 MUCH MORE PRODUCTIVE, THANK 2766 01:57:33,880 --> 01:57:34,160 YOU. 2767 01:57:34,160 --> 01:57:36,200 >>ALL RIGHT WE'LL TAKE THE 15 2768 01:57:36,200 --> 01:57:40,240 MINUTE BREAK THEN. 2769 01:57:40,240 --> 01:57:42,600 >>WE'RE GOING TO GET 2770 01:57:42,600 --> 01:57:43,880 STARTED WITH OUR FIRST 2771 01:57:43,880 --> 01:57:44,360 PRESENTATION. 2772 01:57:44,360 --> 01:57:45,640 JOHN, ARE YOU GOING TO 2773 01:57:45,640 --> 01:57:47,880 INTRODUCE OUR FIRST SPEAKER? 2774 01:57:47,880 --> 01:57:50,120 YOU COULD COME TO THE 2775 01:57:50,120 --> 01:57:58,480 MICROPHONE THEN? 2776 01:57:58,480 --> 01:58:01,160 YEAH, THANKS. 2777 01:58:01,160 --> 01:58:03,120 >>GOOD AFTERNOON, EVERYBODY, 2778 01:58:03,120 --> 01:58:04,240 JOHN WAYNE, DIVISION OF 2779 01:58:04,240 --> 01:58:08,000 BIOLOGY, IT IS MY PLEASURE TO 2780 01:58:08,000 --> 01:58:11,720 INTRODUCE OUR SPEAKER. 2781 01:58:11,720 --> 01:58:13,000 Dr. HONG-WEN DENG IS 2782 01:58:13,000 --> 01:58:16,520 PROFESSOR AND CHIEF OF 2783 01:58:16,520 --> 01:58:22,240 DIVISION OF BY BIOMEDICAL 2784 01:58:22,240 --> 01:58:25,200 INFORMATICS MEDICINE AT 2785 01:58:25,200 --> 01:58:25,920 TULANE. 2786 01:58:25,920 --> 01:58:28,800 HE HAS A PH.D. IN QUALM TATIVE 2787 01:58:28,800 --> 01:58:31,680 GENETICS AND THEN DID A 2788 01:58:31,680 --> 01:58:35,640 POST-DOC IN MOLEC ULAR 2789 01:58:35,640 --> 01:58:39,800 GENETICS AND AS A BRIEF 2790 01:58:39,800 --> 01:58:43,240 BACKGROUND, PIONEERED 2791 01:58:43,240 --> 01:58:45,240 APPROACHES IN MULTI-GENOMICS 2792 01:58:45,240 --> 01:58:49,040 APPLICATIONS IN DESCRIBING 2793 01:58:49,040 --> 01:58:50,440 WHISK FOR OSTEOPOROSIS POSES 2794 01:58:50,440 --> 01:58:52,360 AND HAS RECENTLY STARTED 2795 01:58:52,360 --> 01:58:55,080 WORKING WITH Dr. MILLER IN 2796 01:58:55,080 --> 01:58:57,560 THE DIVISION OF NEUROSCIENCE 2797 01:58:57,560 --> 01:59:01,000 AND LEVERAGING HIS LARGE 2798 01:59:01,000 --> 01:59:02,840 DIVERSE COHORT FOR AD AS WELL. 2799 01:59:02,840 --> 01:59:05,680 AND I AM LOOKING VERY MUCH 2800 01:59:05,680 --> 01:59:16,200 FORWARD TO HEARING HIS TALK. 2801 01:59:22,320 --> 01:59:30,720 I AM HONG-WE N DENG, DIVISION 2802 01:59:30,720 --> 01:59:31,680 CHIEF AND DIRECTOR. 2803 01:59:31,680 --> 01:59:34,800 THANK YOU SO MUCH FOR BEING 2804 01:59:34,800 --> 01:59:38,400 HERE, DEEPLY HUMBLED BY YOUR 2805 01:59:38,400 --> 01:59:38,960 PRESENTATION. 2806 01:59:38,960 --> 01:59:47,600 OSTEOPORES, WE CALL IT A LOST 2807 01:59:47,600 --> 01:59:49,320 STUDY AND THE PURPOSE OF THE 2808 01:59:49,320 --> 01:59:53,520 STUDY IS WE JUST DON'T LOSE 2809 01:59:53,520 --> 01:59:58,200 OUR FISCAL AND MENTAL AFFINITY 2810 01:59:58,200 --> 02:00:00,920 WHICH WE COULD LAST LONGER 2811 02:00:00,920 --> 02:00:03,120 DURING THE AGING. 2812 02:00:03,120 --> 02:00:06,400 AS YOU KNOW, THE ULTIMATE 2813 02:00:06,400 --> 02:00:08,240 OUTCOME, CLINICAL OUTCOME OF 2814 02:00:08,240 --> 02:00:15,760 DISEASE IS TERMED BY MANY 2815 02:00:15,760 --> 02:00:17,920 FACTORS. 2816 02:00:17,920 --> 02:00:19,960 THE MULTI-OMICS NETWORKS FOR 2817 02:00:19,960 --> 02:00:23,480 DISEASE INCLUDING MANY FACTORS 2818 02:00:23,480 --> 02:00:24,520 OF SOCIOAND ECONOMYING HEALTH 2819 02:00:24,520 --> 02:00:27,400 AND IN THE PAST MOST OF OUR 2820 02:00:27,400 --> 02:00:35,200 EFFORTS HAVE BEEN FOCUSED ON 2821 02:00:35,200 --> 02:00:37,720 INDIVIDUAL HEALTH, OMICS 2822 02:00:37,720 --> 02:00:39,440 STUDIES UNCOVERED A LARGE 2823 02:00:39,440 --> 02:00:42,480 NUMBER OF NOVEL LO CI FOR 2824 02:00:42,480 --> 02:00:44,040 HUMAN COMPLEX DISEASES. 2825 02:00:44,040 --> 02:00:45,320 THIS PROVIDES USEFUL 2826 02:00:45,320 --> 02:00:47,160 INFORMATION AND PUSHED THE 2827 02:00:47,160 --> 02:00:50,720 FIELD A LOT FORWARD. 2828 02:00:50,720 --> 02:00:55,520 HOWEVER AND WE SEE A LOT OF 2829 02:00:55,520 --> 02:00:57,120 SIMILARITIES IN OSTEOPORES AND 2830 02:00:57,120 --> 02:01:01,720 OTHER FIELDS AS WELL. 2831 02:01:01,720 --> 02:01:12,160 HOWEVER THE SPECIFIC 2832 02:01:14,320 --> 02:01:16,080 FUNCTIONAL GENOMICS VARIANTS 2833 02:01:16,080 --> 02:01:24,200 AND CAUSAL GENES ARE LARGELY 2834 02:01:24,200 --> 02:01:25,800 UNKNOWN. 2835 02:01:25,800 --> 02:01:29,800 THE GENERAL HYPOTHESIS THAT 2836 02:01:29,800 --> 02:01:33,240 INTEGRATIVE TRANS-OMICS 2837 02:01:33,240 --> 02:01:34,200 ANALYSIS OF MULTI-OMICS DATA 2838 02:01:34,200 --> 02:01:37,640 WILL BE MUCH MORE PRODUCTIVE 2839 02:01:37,640 --> 02:01:42,800 AND POWERFUL NOT ONLY 2840 02:01:42,800 --> 02:01:45,400 IDENTIFYING RISK BUT ALSO 2841 02:01:45,400 --> 02:01:47,160 IMPORTANT ILLUMINATING 2842 02:01:47,160 --> 02:01:49,680 FUNCTIONS IN VIVO IN HUMANS. 2843 02:01:49,680 --> 02:01:55,960 THIS IS A NIH AND LOCAL 2844 02:01:55,960 --> 02:01:57,280 SUPPORTED OMICS STUDY. 2845 02:01:57,280 --> 02:02:03,280 I AM VERY GRATEFUL FOR OUR 2846 02:02:03,280 --> 02:02:05,640 OFFICERS AND THE GRANTS 2847 02:02:05,640 --> 02:02:09,720 HELPING ME DO THIS RESEARCH 2848 02:02:09,720 --> 02:02:11,680 WITH A LOT OF HOURS SO THANK 2849 02:02:11,680 --> 02:02:15,520 YOU FOR YOUR HARD WORK. 2850 02:02:15,520 --> 02:02:18,560 AND WE HAVE AN INTERESTING 2851 02:02:18,560 --> 02:02:22,000 GROUP USING NOT ONLY 2852 02:02:22,000 --> 02:02:30,360 TECHNOLOGY, WE ALSO DEVELOP 2853 02:02:30,360 --> 02:02:40,920 METHODOLOGY BY GRANTS FROM THE 2854 02:02:41,320 --> 02:02:43,640 INSTITUTE IN GENETICS AND 2855 02:02:43,640 --> 02:02:46,120 QUANTUM GENETICS. 2856 02:02:46,120 --> 02:02:50,920 DURING THE YEAR WE HAVE 2857 02:02:50,920 --> 02:02:54,520 DETERMINED A COHORT WITH THE 2858 02:02:54,520 --> 02:02:58,040 OMAHA OSTEOPORES STUDY WITH 2859 02:02:58,040 --> 02:03:04,880 OVER 4000 PATIENTS AND OVER 2860 02:03:04,880 --> 02:03:08,840 3250 SUCKED FROM 800 NUCLEAR 2861 02:03:08,840 --> 02:03:09,240 FAMILIES. 2862 02:03:09,240 --> 02:03:14,000 AND ALSO THE KANSAS CITY 2863 02:03:14,000 --> 02:03:19,160 OSTEOPOROSIS STUDY WITH OVER 2864 02:03:19,160 --> 02:03:23,080 5000 SUBJECTS. 2865 02:03:23,080 --> 02:03:28,520 AND THEN LOST, I MOVED TO 2866 02:03:28,520 --> 02:03:31,560 LOUISIANA AS YO POSES, A 2867 02:03:31,560 --> 02:03:34,160 DIFFERENT COHORT OF CURRENTLY 2868 02:03:34,160 --> 02:03:41,960 OVER 17,000 AND WE HAVE 2869 02:03:41,960 --> 02:03:50,840 MULTIPLE PROJECTS FOR 2870 02:03:50,840 --> 02:03:54,480 MEASURING BONE, BODY MASS, 2871 02:03:54,480 --> 02:03:57,000 LEAN MASS. 2872 02:03:57,000 --> 02:04:03,600 THERE ARE DIVERSE DATA THROUGH 2873 02:04:03,600 --> 02:04:11,400 YES NARROWS ASKING FOR SO MANY 2874 02:04:11,400 --> 02:04:12,400 DETERMINANTS OF HEALTH AND 2875 02:04:12,400 --> 02:04:16,480 OTHER SUBJECTS AND SOME OF 2876 02:04:16,480 --> 02:04:20,480 THESE SUBJECTS WERE ALSO AS 2877 02:04:20,480 --> 02:04:21,120 SAID FOR COVID-19. 2878 02:04:21,120 --> 02:04:23,040 SO THIS IS THE DATA WE HAVE 2879 02:04:23,040 --> 02:04:29,320 CURRENTLY AND YOU CAN SEE THAT 2880 02:04:29,320 --> 02:04:31,920 UNITING THE DATA FROM THE 2881 02:04:31,920 --> 02:04:37,560 STUDIES, IT INCLUDES DIFFERENT 2882 02:04:37,560 --> 02:04:38,200 ETHNICITIES. 2883 02:04:38,200 --> 02:04:40,960 MANY CAUCASIANS AND 2884 02:04:40,960 --> 02:04:43,440 AFRICAN-AMERICANS, SOME ASIAN, 2885 02:04:43,440 --> 02:04:46,200 HISPANIC AND OTHERS, 2886 02:04:46,200 --> 02:04:47,360 INDIGENOUS, INDIANS AND 2887 02:04:47,360 --> 02:04:49,640 PACIFIC ISLANDERS AND THE MOST 2888 02:04:49,640 --> 02:04:51,560 SUBSTANTIAL DATA WE FOUND IS 2889 02:04:51,560 --> 02:04:57,920 HERE AND THEN THROUGH THE LOST 2890 02:04:57,920 --> 02:05:01,960 STUDY, THE JUNE 19TH STUDY. 2891 02:05:01,960 --> 02:05:06,120 THIS IS ALL CURRENTLY AND 2892 02:05:06,120 --> 02:05:10,200 STILL EXPANDING. 2893 02:05:10,200 --> 02:05:15,280 OUR MULTI-OMICS DATA WILL 2894 02:05:15,280 --> 02:05:25,760 FOCUS ON THE CELLS, THE 2895 02:05:30,080 --> 02:05:33,520 OSTEOCLATOGENIC CELLS THAT WE 2896 02:05:33,520 --> 02:05:34,880 SEE IN OSTEOPOROSIS. 2897 02:05:34,880 --> 02:05:42,520 THIS IS OUR RECENT 2898 02:05:42,520 --> 02:05:44,960 COMPUTATIONS FOR THE 2899 02:05:44,960 --> 02:05:46,440 MULTI-OMICS STUDY AND I WANT 2900 02:05:46,440 --> 02:05:52,200 TO HIGHLIGHT TWO STUDIES. 2901 02:05:52,200 --> 02:05:57,880 ONE IS THE DATA FOR 2902 02:05:57,880 --> 02:05:59,360 IDENTIFYING OSTEOPOROSIS 2903 02:05:59,360 --> 02:06:01,520 BIOMARKERS AND BIOLOGICAL 2904 02:06:01,520 --> 02:06:03,680 INTERACTION AND CAUSAL 2905 02:06:03,680 --> 02:06:05,320 MECHANISMS. 2906 02:06:05,320 --> 02:06:08,080 AND WE KNOW OSTEOPOROSIS 2907 02:06:08,080 --> 02:06:10,680 ESPECIALLY IN WOMEN AROUND THE 2908 02:06:10,680 --> 02:06:11,840 AGE OF 50 THEY EXPERIENCE LOSS 2909 02:06:11,840 --> 02:06:22,360 OF BONE MASS AND INCREASED 2910 02:06:23,320 --> 02:06:27,240 SUSCEPTIBILITY TO OSTEOPOROTIC 2911 02:06:27,240 --> 02:06:27,840 FRACTURE. 2912 02:06:27,840 --> 02:06:32,640 SO IN THIS STUDY WE SEE A HIGH 2913 02:06:32,640 --> 02:06:34,680 AND A LOW IN THE RANGE AND 2914 02:06:34,680 --> 02:06:36,880 VERY IMPORTANT FOR THESE 2915 02:06:36,880 --> 02:06:42,640 GROUPS. 2916 02:06:42,640 --> 02:06:47,120 FOR THE OMICS SIDE, WE 2917 02:06:47,120 --> 02:06:57,640 CHARACTERIZED THE GENOME AND 2918 02:06:58,600 --> 02:07:09,000 WE THEN WE INTEGRATED THE 2919 02:07:10,960 --> 02:07:12,800 CELLS TO MONITOR GROUPS OF 2920 02:07:12,800 --> 02:07:17,480 MARKERS THAT INTERACT AND THEN 2921 02:07:17,480 --> 02:07:24,400 LOOK AT THAT IN GENERAL FOR 2922 02:07:24,400 --> 02:07:30,440 THE PROTEIN NETWORK AND ALSO 2923 02:07:30,440 --> 02:07:33,480 USED THE MENDELIAN 2924 02:07:33,480 --> 02:07:42,920 RANDOMIZATION TO EXPRESS THE 2925 02:07:42,920 --> 02:07:44,600 CAUSAL SOURCES FOR BMD. 2926 02:07:44,600 --> 02:07:47,040 SO THIS IS THE SPECIFIC 2927 02:07:47,040 --> 02:07:53,640 CORPATION WE USED FOR THIS AND 2928 02:07:53,640 --> 02:08:02,800 AS FAR AS METHODS, USED VERY 2929 02:08:02,800 --> 02:08:06,560 FEW ASSUMPTIONS AND REVIEW THE 2930 02:08:06,560 --> 02:08:09,960 MAGNITUDE OF PATIENTS WHO HAVE 2931 02:08:09,960 --> 02:08:20,520 OSTEOPOROSIS AND SEE THEY ARE 2932 02:08:23,360 --> 02:08:27,400 OVERCOME WITH THIS MENDELIAN 2933 02:08:27,400 --> 02:08:32,760 AND WE THIS ACROSS OMICS. 2934 02:08:32,760 --> 02:08:35,200 CAPTURING CORRELATION BETWEEN 2935 02:08:35,200 --> 02:08:39,400 DIFFERENT OMIC SUBSETS THAT 2936 02:08:39,400 --> 02:08:45,000 CAN BE TESTED. 2937 02:08:45,000 --> 02:08:50,840 SO WE USE THIS RANDOMIZATION 2938 02:08:50,840 --> 02:08:54,280 ANALYSIS TO TEST CAUSAL 2939 02:08:54,280 --> 02:08:56,920 EFFECTS FOR SIGNIFICANT 2940 02:08:56,920 --> 02:08:58,520 BIOMARKERS AND THIS IS OVER 2941 02:08:58,520 --> 02:09:01,240 HALF A MILLION, A VERY BIG 2942 02:09:01,240 --> 02:09:06,400 SAMPLE FOR BMD ANALYSIS. 2943 02:09:06,400 --> 02:09:12,920 AND WE USE THAT ANALYSIS, WE 2944 02:09:12,920 --> 02:09:17,800 IDENTIFY THREE COMPONENTS, 2945 02:09:17,800 --> 02:09:19,760 HIGHLY INTERACTIVE GROUPS 2946 02:09:19,760 --> 02:09:24,120 ACROSS DIFFERENT OMICS AND 2947 02:09:24,120 --> 02:09:33,600 THIS IS THE RESULTS WITH THE 2948 02:09:33,600 --> 02:09:37,240 FEATURES AND YOU CAN SEE A LOT 2949 02:09:37,240 --> 02:09:39,560 OF INTERACTIONS, CONNECTIONS 2950 02:09:39,560 --> 02:09:40,920 ACROSS DIFFERENT OMICS AND 2951 02:09:40,920 --> 02:09:45,360 INTERESTING THAT ONE EXAMINER 2952 02:09:45,360 --> 02:09:52,240 TO HIGHLIGHT, THIS EX 2953 02:09:52,240 --> 02:09:55,720 SUPPRESSION OF HAUS2 WITH 2954 02:09:55,720 --> 02:09:58,680 POSITIVE CORRELATION WITH 2955 02:09:58,680 --> 02:10:06,800 METHYLATION AND ALSO 2956 02:10:06,800 --> 02:10:08,600 METABOLITE THEONINE AND THAT 2957 02:10:08,600 --> 02:10:10,240 SEEMS TO IMPLY THE STRONG 2958 02:10:10,240 --> 02:10:15,200 INTERACTION WITH THESE TWO 2959 02:10:15,200 --> 02:10:22,000 THINGS AND THIS IS BIO MARKER 2960 02:10:22,000 --> 02:10:23,480 FROM OUR OMICS. 2961 02:10:23,480 --> 02:10:25,440 INTERESTINGLY THERE IS 2962 02:10:25,440 --> 02:10:29,360 SIGNIFICANT INTERACTION 2963 02:10:29,360 --> 02:10:34,320 BETWEEN HAUS2 WITH 2964 02:10:34,320 --> 02:10:35,560 PROTEIN-PROTEIN INTERACTION 2965 02:10:35,560 --> 02:10:36,760 AND THERE'S A LOT OF 2966 02:10:36,760 --> 02:10:38,400 CONNECTIONS THAT YOU SEE FROM 2967 02:10:38,400 --> 02:10:41,080 THE DATA HERE. 2968 02:10:41,080 --> 02:10:50,120 AND WE DID THIS RESEARCH AND 2969 02:10:50,120 --> 02:10:57,240 MAPPED THOSE THINGS INTO THE 2970 02:10:57,240 --> 02:11:00,560 VERY IMPORTANT RATES KNOWN TO 2971 02:11:00,560 --> 02:11:02,040 CAUSE OSTEOPOROSIS BUT MANY OF 2972 02:11:02,040 --> 02:11:03,680 THOSE THINGS ARE NORMAL AND 2973 02:11:03,680 --> 02:11:10,640 THOSE THAT ARE NOT NORMAL 2974 02:11:10,640 --> 02:11:16,600 ALREADY ARE HIGHLIGHTED IN 2975 02:11:16,600 --> 02:11:18,760 BOTH PLACE, NORMAL ONES 2976 02:11:18,760 --> 02:11:21,040 INTERACT AND ARE CONNECTED 2977 02:11:21,040 --> 02:11:24,840 WITH THE NORMAL ONES, THE 2978 02:11:24,840 --> 02:11:25,800 NORMAL PATHWAY. 2979 02:11:25,800 --> 02:11:30,720 AND THE RANDOMIZATION ANALYSIS 2980 02:11:30,720 --> 02:11:35,120 REVEALS THAT THIS WHICH I WILL 2981 02:11:35,120 --> 02:11:38,680 HIGHLIGHT HAS A SIGNIFICANT 2982 02:11:38,680 --> 02:11:42,480 CAUSE FOR BMD AND THIS STUDY, 2983 02:11:42,480 --> 02:11:47,960 THIS PREVIOUS STUDY IDENTIFIED 2984 02:11:47,960 --> 02:11:56,080 THE GENE EXPRESSION OF FADS2. 2985 02:11:56,080 --> 02:11:58,160 THE PREVIOUS METAANALYSIS HAS 2986 02:11:58,160 --> 02:12:04,640 SHOWN VARIANTS IN FADS2 WERE 2987 02:12:04,640 --> 02:12:08,120 ASSOCIATED WITH HEEL BMD. 2988 02:12:08,120 --> 02:12:11,600 SO THE TRANSO MIC MODELS, WE 2989 02:12:11,600 --> 02:12:20,240 TOOK THREE OM ICS AND 2990 02:12:20,240 --> 02:12:25,760 IDENTIFIED IN 61 GENES THE 2991 02:12:25,760 --> 02:12:32,440 DEGS INTERACTING WITH BMD 2992 02:12:32,440 --> 02:12:34,120 VARIATION. 2993 02:12:34,120 --> 02:12:36,800 THIS RECONSTRUCTED INTEGRATIVE 2994 02:12:36,800 --> 02:12:38,840 NETWORKS REVEALED SUBSTANTIAL 2995 02:12:38,840 --> 02:12:40,920 PROPORTION OF THESE BIOMARKERS 2996 02:12:40,920 --> 02:12:43,160 NOT ONLY INTERACTED WITH EACH 2997 02:12:43,160 --> 02:12:47,680 OTHER BUT ALSO ENRICHED IN 2998 02:12:47,680 --> 02:12:49,640 SEVERAL WELL-KNOWN SIGNALING 2999 02:12:49,640 --> 02:12:51,800 PATHWAYS OR FUNCTIONAL 3000 02:12:51,800 --> 02:12:57,400 ACTIVITIES THAT ARE CRUCIAL 3001 02:12:57,400 --> 02:13:05,640 FOR OSTEOBLASTOGENESIS AND 3002 02:13:05,640 --> 02:13:06,200 OSTEOCLASTOGENESIS. 3003 02:13:06,200 --> 02:13:10,480 WE THEN IN THIS STUDY LOOK AT 3004 02:13:10,480 --> 02:13:18,040 GUT MICROBIOTA AND HOW IT 3005 02:13:18,040 --> 02:13:23,840 IMPACTED THE BONE VIA 3006 02:13:23,840 --> 02:13:31,480 B.VULGATUS AND IT IS CLEAR THE 3007 02:13:31,480 --> 02:13:33,080 MULTIBIOME AND IN THIS STUDY 3008 02:13:33,080 --> 02:13:35,040 WE TOOK IT A STEP FURTHER. 3009 02:13:35,040 --> 02:13:37,800 WE TOP LATE THE STUDY HERE IN 3010 02:13:37,800 --> 02:13:41,560 AN INDEPENDENT POPULATION AND 3011 02:13:41,560 --> 02:13:45,560 ALSO WE PERFORMED FURTHER 3012 02:13:45,560 --> 02:13:47,760 INVIVO FOR THE FINDINGS WE 3013 02:13:47,760 --> 02:13:48,040 HAVE. 3014 02:13:48,040 --> 02:13:52,000 SO WE DID A REGULAR MICRO 3015 02:13:52,000 --> 02:13:54,960 GENOMIC STUDY TO IDENTIFY THE 3016 02:13:54,960 --> 02:14:05,560 BACTERIA IN THE FECES SPECIES. 3017 02:14:07,240 --> 02:14:14,760 AND WE FIND THERE ARE OTHER 3018 02:14:14,760 --> 02:14:22,040 THINGS ASSOCIATED WITH BMD. 3019 02:14:22,040 --> 02:14:29,160 THE MULTI-OMIC IDENTIFIED IN 3020 02:14:29,160 --> 02:14:34,600 THIS VALERIC ACID AND WE 3021 02:14:34,600 --> 02:14:35,520 PERFORMED WITH RANDOMIZATION 3022 02:14:35,520 --> 02:14:41,240 AND ACTUALLY THE VULGATUS 3023 02:14:41,240 --> 02:14:47,200 CAUSED BY SUGAR, THE VULGATUS 3024 02:14:47,200 --> 02:14:47,520 LEVELS. 3025 02:14:47,520 --> 02:14:52,400 AND AGAIN WE PERFORMED AN 3026 02:14:52,400 --> 02:14:54,040 INDEPENDENT VALIDATION IN 3027 02:14:54,040 --> 02:14:55,200 ANOTHER INDEPENDENT COHORT. 3028 02:14:55,200 --> 02:15:02,720 SO WE TOOK THIS EVIDENCE, WE 3029 02:15:02,720 --> 02:15:07,120 SAY WHY WAS THIS FUNCTIONAL OR 3030 02:15:07,120 --> 02:15:16,480 VALECIC AND THEN PERFORMED MY 3031 02:15:16,480 --> 02:15:20,720 STUDY THROUGH ORAL GAVAGE 3032 02:15:20,720 --> 02:15:25,120 EXPERIMENTS AND WHAT WE FIND 3033 02:15:25,120 --> 02:15:30,480 IS WITH THOSE WITH VULGATUS 3034 02:15:30,480 --> 02:15:32,320 BACTERIA, THEY ARE NOT AS 3035 02:15:32,320 --> 02:15:35,520 FIXED AS THE HEALTHY IN THE 3036 02:15:35,520 --> 02:15:38,160 BONE AND THE MINERALIZATION IS 3037 02:15:38,160 --> 02:15:41,280 NOT AS GOOD AND THE NUMBER 3038 02:15:41,280 --> 02:15:50,440 INCREASES COMPARED WITH 3039 02:15:50,440 --> 02:15:53,520 CONTROL. 3040 02:15:53,520 --> 02:15:58,600 AND WE ALSO SEE BY THE 3041 02:15:58,600 --> 02:16:05,280 ANALYSIS OF THE BIOME, WE 3042 02:16:05,280 --> 02:16:12,120 FOUND THIS BACTERIA THAT 3043 02:16:12,120 --> 02:16:13,800 PRODUCE VALERIC ACID. 3044 02:16:13,800 --> 02:16:20,720 AND FOR THE VA LERIC ACID, WE 3045 02:16:20,720 --> 02:16:22,160 ALSO DID SOME EXPERIMENTS AND 3046 02:16:22,160 --> 02:16:26,400 SEE THE MICE WITH THE VALERIC 3047 02:16:26,400 --> 02:16:34,280 ACID HAS BIGGER BONES AND MORE 3048 02:16:34,280 --> 02:16:35,160 MINERALIZATION AND MASS. 3049 02:16:35,160 --> 02:16:41,680 AND WE FURTHER PERFORMED HOW 3050 02:16:41,680 --> 02:16:50,200 THESE VALERIC ACID WILL 3051 02:16:50,200 --> 02:16:51,160 INFLUENCE THE MINERALIZATION 3052 02:16:51,160 --> 02:16:59,400 AND IT SHOWS THE VALERIC ACID 3053 02:16:59,400 --> 02:17:04,520 CAN DECREASE AND INCREASE THE 3054 02:17:04,520 --> 02:17:08,360 OSTEOBLAST ENGAGING IN 3055 02:17:08,360 --> 02:17:09,640 MINERALIZATION IN STAINING 3056 02:17:09,640 --> 02:17:10,280 CULTURE. 3057 02:17:10,280 --> 02:17:13,560 AND THAT WE SUSPECT THAT WE 3058 02:17:13,560 --> 02:17:18,240 HAVE A SPECIFIC PATHWAY FOR 3059 02:17:18,240 --> 02:17:22,120 THIS LEADING MODELS SO WE 3060 02:17:22,120 --> 02:17:23,360 HYPOTHESIZED THE INFLAMMATION 3061 02:17:23,360 --> 02:17:26,360 PATHWAY WHICH IS IMPORTANT FOR 3062 02:17:26,360 --> 02:17:27,720 THE MINERALIZATION BLOCK, WE 3063 02:17:27,720 --> 02:17:31,880 HAVE THREE THINGS IN THE 3064 02:17:31,880 --> 02:17:36,560 PROTEINS LIKE AN OF A VERY CAT 3065 02:17:36,560 --> 02:17:47,000 DOUGH, P65 AND IL10 IN 3066 02:17:48,880 --> 02:17:50,920 CULTURED OSTEOCLAST-LIKE CELLS 3067 02:17:50,920 --> 02:17:55,720 AND OSTEOBLAST CELLS AND WE 3068 02:17:55,720 --> 02:18:00,800 FIND THE EXPRESSION OF 3069 02:18:00,800 --> 02:18:03,360 PRO-INFLAMMATORY CYTOKINE AND 3070 02:18:03,360 --> 02:18:08,800 THIS IS INCREASED AND 3071 02:18:08,800 --> 02:18:12,400 DECREASED EXPRESSION OF 3072 02:18:12,400 --> 02:18:22,960 PRO-INFLAMMATORY CYTOKINE SO 3073 02:18:24,280 --> 02:18:30,800 WE PROPOSED SOME STUDY WHERE 3074 02:18:30,800 --> 02:18:34,720 VALERIC ACID PRODUCING SPECIES 3075 02:18:34,720 --> 02:18:36,880 TO REDUCE VALERIC ACID 3076 02:18:36,880 --> 02:18:39,240 PRODUCTION WITHIN THE GUT. 3077 02:18:39,240 --> 02:18:41,800 WE ALSO PERFORMED OTHER STUDY 3078 02:18:41,800 --> 02:18:43,960 THAT I DON'T HAVE TIME TO TALK 3079 02:18:43,960 --> 02:18:48,240 ABOUT BUT I WOULD LIKE TO SAY 3080 02:18:48,240 --> 02:18:50,840 THIS. 3081 02:18:50,840 --> 02:18:59,840 THIS IS THE JUNIOR FACTOR FOR 3082 02:18:59,840 --> 02:19:03,800 INTEGRATION AND AS YOU CAN SEE 3083 02:19:03,800 --> 02:19:11,520 IT IS VERY, VERY BRILLIANT 3084 02:19:11,520 --> 02:19:13,480 EFFECT. 3085 02:19:13,480 --> 02:19:17,760 AND SO WE STARTED LOOKING AT 3086 02:19:17,760 --> 02:19:21,240 OSTEOPOROSIS BUT THIS RELATES 3087 02:19:21,240 --> 02:19:26,920 TO A LOT OF OTHER RISK LIKE 3088 02:19:26,920 --> 02:19:28,920 ALZHEIMER'S MECHANISMS IN 3089 02:19:28,920 --> 02:19:30,800 DIVERSE POPULATIONS AND THE 3090 02:19:30,800 --> 02:19:37,920 WHOLE EXCHANGE OF MUSCLE MASS 3091 02:19:37,920 --> 02:19:44,560 AND MUSCLE LEAN BUT THIS STUDY 3092 02:19:44,560 --> 02:19:50,520 FOR ALZHEIMER'S GENETIC RISK 3093 02:19:50,520 --> 02:19:55,440 HIGHER IN AFRICAN-AMERICANS SO 3094 02:19:55,440 --> 02:19:57,400 WE DID 2.0 STUDY. 3095 02:19:57,400 --> 02:20:02,600 THIS WAS 20 YEARS AGO IN LONG 3096 02:20:02,600 --> 02:20:06,320 PAPER AND THE REASON WHY IT 3097 02:20:06,320 --> 02:20:10,200 LAST MORE, THOSE ARE KIND OF 3098 02:20:10,200 --> 02:20:15,960 PUBLISHED AND LIKE TO MENTION 3099 02:20:15,960 --> 02:20:19,800 THIS IS AFRICAN AMERICAN 3100 02:20:19,800 --> 02:20:21,600 STUDENT AND THIS IS 3101 02:20:21,600 --> 02:20:22,600 UNDERGRADUATE STUDENT GOING 3102 02:20:22,600 --> 02:20:25,040 THROUGH SCHOOL AND GOING TO DO 3103 02:20:25,040 --> 02:20:26,640 RESEARCH SHE SAID IN THE 3104 02:20:26,640 --> 02:20:27,720 FUTURE. 3105 02:20:27,720 --> 02:20:32,880 SO AND WE ALSO DID 3106 02:20:32,880 --> 02:20:43,360 CUTTING-EDGE LIKE DRUG 3107 02:20:44,360 --> 02:20:45,960 REPURPOSING AND OMICS USING 3108 02:20:45,960 --> 02:20:48,880 OUR OWN DATA WITH PUBLIC DATA 3109 02:20:48,880 --> 02:20:51,640 AND WHAT WE ARE TRYING TO 3110 02:20:51,640 --> 02:20:57,440 PROPOSE IS WE TRIED TO CONNECT 3111 02:20:57,440 --> 02:21:02,480 A COHORT ABOUT 13,000 SUBJECTS 3112 02:21:02,480 --> 02:21:13,000 AND TO USE FOR THE WHOLE 3113 02:21:14,960 --> 02:21:20,920 GENOME SEQUENCING STUDY, AND 3114 02:21:20,920 --> 02:21:23,400 COLLABORATE WITH ADSP-FU.S. 3115 02:21:23,400 --> 02:21:25,960 CONSORTIM TO LOOK AT THE DATA 3116 02:21:25,960 --> 02:21:30,760 AND LEVERAGE OUR EXISTING U19 3117 02:21:30,760 --> 02:21:36,040 PROJECT MULTI-OMICS DATA TO 3118 02:21:36,040 --> 02:21:41,840 IMPUTE VARIOUS OMICS, 3119 02:21:41,840 --> 02:21:44,840 TRANSCRIPTOME AND METHYLOME OF 3120 02:21:44,840 --> 02:21:50,960 PBM AND SERUM METABOLOME AND 3121 02:21:50,960 --> 02:21:53,960 LIPIDOME DATA IN THE COMBINED 3122 02:21:53,960 --> 02:21:57,120 ADSP COHORTS AND THEN WE CAN 3123 02:21:57,120 --> 02:22:02,080 TRANSFORM THE DATA IN THE 3124 02:22:02,080 --> 02:22:06,240 ANALYSIS AND IN SINGLE NUCLEI, 3125 02:22:06,240 --> 02:22:08,560 TRY TO IDENTIFY WHAT GENES, 3126 02:22:08,560 --> 02:22:13,160 WHAT CELL, HOW THEY INTERACT 3127 02:22:13,160 --> 02:22:16,680 IN THE SPATIAL CONTACT WITH 3128 02:22:16,680 --> 02:22:22,320 HUMANS WITH THE HUMAN BRAIN OR 3129 02:22:22,320 --> 02:22:22,640 TISSUE. 3130 02:22:22,640 --> 02:22:27,560 SO I WOULD LIKE TO BRING THIS 3131 02:22:27,560 --> 02:22:28,440 TO YOUR ATTENTION. 3132 02:22:28,440 --> 02:22:30,760 MANY OF YOU ARE EXPERTS AND 3133 02:22:30,760 --> 02:22:34,600 KNOW MORE THAN I DO BUT FOR ME 3134 02:22:34,600 --> 02:22:38,240 IT IS NEW. 3135 02:22:38,240 --> 02:22:41,520 THE PBMS WE STUDY FOR MORE 3136 02:22:41,520 --> 02:22:44,080 THAN 20 YEARS FOR OSTEOPOROSIS 3137 02:22:44,080 --> 02:22:52,240 TURNED OUT TO PLAY A MAJOR 3138 02:22:52,240 --> 02:22:57,960 ROLE AND PBMS INSTATE THE 3139 02:22:57,960 --> 02:23:01,480 BRAIN PARENCHYMA TARGETING AB 3140 02:23:01,480 --> 02:23:04,320 PLAQUES TO REDUCE PLAQUE LOAD 3141 02:23:04,320 --> 02:23:09,280 AND PBMS BEHAVE AS HOUSEKEEPER 3142 02:23:09,280 --> 02:23:12,720 WITHIN VAS CHEWER BY 3143 02:23:12,720 --> 02:23:15,880 ELIMINATING AB MICRO 3144 02:23:15,880 --> 02:23:20,400 AGGREGATES FROM BRAIN MICRO 3145 02:23:20,400 --> 02:23:21,640 VASCULATURE IN BLOOD 3146 02:23:21,640 --> 02:23:22,800 CIRCUMSTANCE CONSIDERATION. 3147 02:23:22,800 --> 02:23:30,760 IN 40 TO 60 PERCENT OF AB 3148 02:23:30,760 --> 02:23:32,680 PATIENTS GENERATED IN BRAIN 3149 02:23:32,680 --> 02:23:34,680 DIFFUSE IN BLOOD AND BE 3150 02:23:34,680 --> 02:23:38,880 CLEARED IN PER RIF REMAINLY IN 3151 02:23:38,880 --> 02:23:39,840 PBMS. 3152 02:23:39,840 --> 02:23:44,200 ABILITY OF AP UPTAKE BY PBMS 3153 02:23:44,200 --> 02:23:46,480 DECREASE WITH AGING AND 3154 02:23:46,480 --> 02:23:49,040 FURTHER DECREASE IN AD 3155 02:23:49,040 --> 02:23:59,120 PATIENTS AND THIS IS THE 3156 02:23:59,120 --> 02:24:02,840 REVIEW INTRODUCING THE STUDY 3157 02:24:02,840 --> 02:24:06,360 THE SITES THAT HAVE DIFFERENT 3158 02:24:06,360 --> 02:24:10,560 FUNCTIONS AND ONE THING THE 3159 02:24:10,560 --> 02:24:12,760 MONO SITES IS MUCH EASIER TO 3160 02:24:12,760 --> 02:24:15,600 COPY IN THE CELL, IN THE BRAIN 3161 02:24:15,600 --> 02:24:21,640 BECAUSE OF THE BLOOD BRAIN 3162 02:24:21,640 --> 02:24:22,000 BARRIER. 3163 02:24:22,000 --> 02:24:26,120 SO THIS COULD BE NEW TARGET 3164 02:24:26,120 --> 02:24:29,880 CELL FOR AB STUDY. 3165 02:24:29,880 --> 02:24:40,360 SO THIS IS THE OVERVIEW OF 3166 02:24:41,360 --> 02:24:44,320 RESEARCH PLAN AND WHAT I 3167 02:24:44,320 --> 02:24:50,000 INTRODUCED IS NOT NEW. 3168 02:24:50,000 --> 02:24:57,480 THE METHOD FROM TEN YEARS 3169 02:24:57,480 --> 02:25:04,000 ALSO, THAT BIOINFORMATIC 3170 02:25:04,000 --> 02:25:08,560 STRATEGY FOR TRANS-OMICS 3171 02:25:08,560 --> 02:25:12,400 IMPUTATION, AND THERE'S OTHER 3172 02:25:12,400 --> 02:25:15,240 METHODS FOR IMPUTATION AT 3173 02:25:15,240 --> 02:25:15,960 DEEPER OMICS LEVELS. 3174 02:25:15,960 --> 02:25:17,400 SO I WOULD LIKE TO BRING THIS 3175 02:25:17,400 --> 02:25:18,520 UP AGAIN FOR THE REFERENCE 3176 02:25:18,520 --> 02:25:24,600 THAT WE CAN USE FOR IMPUTATION 3177 02:25:24,600 --> 02:25:27,640 FOR OMICS AND WE CAN DO THAT 3178 02:25:27,640 --> 02:25:32,520 NOT ONLY FOR ALL BUT FOR 3179 02:25:32,520 --> 02:25:40,120 ETHNIC IN PARTICULAR AND 3180 02:25:40,120 --> 02:25:43,080 ASSURE THE EFFICIENCY OF THE 3181 02:25:43,080 --> 02:25:44,080 DATA. 3182 02:25:44,080 --> 02:25:46,520 THIS IS THE DATA SET WE 3183 02:25:46,520 --> 02:25:48,640 DEVELOPED AND THE PILOT BASES 3184 02:25:48,640 --> 02:25:59,240 WE ACCUMULATED SO FAR AND THIS 3185 02:26:00,920 --> 02:26:06,800 IS FOR THE PEARSON MODEL AND 3186 02:26:06,800 --> 02:26:12,560 ABOUT 60 PERCENT VERY WELL 3187 02:26:12,560 --> 02:26:13,640 PREDICTED THIS GENE. 3188 02:26:13,640 --> 02:26:15,600 I THINK AMERICANS ARE MORE 3189 02:26:15,600 --> 02:26:17,760 THAN 2 PERCENT BUT I DISCUSSED 3190 02:26:17,760 --> 02:26:23,120 WITH PEOPLE AND FIGURE 3191 02:26:23,120 --> 02:26:32,760 ALTHOUGH WE ADJUST FOR 3192 02:26:32,760 --> 02:26:33,840 EXCEPTIONS, THE LOCAL 3193 02:26:33,840 --> 02:26:40,240 EXCEPTION MAY AFFECT THE GENE 3194 02:26:40,240 --> 02:26:44,400 EXPRESSION AND IMPUTATION SO 3195 02:26:44,400 --> 02:26:47,120 WE HOPEFULLY INJECT THE 3196 02:26:47,120 --> 02:26:48,280 METHYLATION TO BRING THIS UP 3197 02:26:48,280 --> 02:26:50,560 AND WITH THIS PROCESS, HOPE TO 3198 02:26:50,560 --> 02:26:52,200 FURTHER IMPROVE. 3199 02:26:52,200 --> 02:27:00,200 AND AGAIN, THIS IS FOR MICRO 3200 02:27:00,200 --> 02:27:02,680 METHYLATION, WE USE THIS MODEL 3201 02:27:02,680 --> 02:27:04,200 BASED ON ORIGINAL COMPUTATION 3202 02:27:04,200 --> 02:27:06,960 IN THIS KIND OF AREA AND TO 3203 02:27:06,960 --> 02:27:09,040 IMPROVE THE PREDICTION AND 3204 02:27:09,040 --> 02:27:15,960 THEN THE DEEPENING, THIS IS 3205 02:27:15,960 --> 02:27:19,200 FOR METABOLITES AND LIPIDOMICS 3206 02:27:19,200 --> 02:27:22,840 AND A LARGE PROGRAMMER OF 3207 02:27:22,840 --> 02:27:25,040 METABOLITES CAN BE PREDICTED 3208 02:27:25,040 --> 02:27:28,320 WITH GOOD ACCURACY AND THIS IS 3209 02:27:28,320 --> 02:27:34,200 AN EXAMPLE TO USE DEEP 3210 02:27:34,200 --> 02:27:40,440 LEARNING AND MODEL PREDICTION 3211 02:27:40,440 --> 02:27:50,520 TO IMPUTE FROM GUT META-OMICS, 3212 02:27:50,520 --> 02:27:56,560 ALL PRODUCED IN THE GUT AND IN 3213 02:27:56,560 --> 02:27:57,280 METABIOME. 3214 02:27:57,280 --> 02:28:03,800 AND YOU CAN SEE IN THE GUT 3215 02:28:03,800 --> 02:28:07,360 THIS FEATURED DIFFERENT 3216 02:28:07,360 --> 02:28:10,440 METAGENOMES AND YOU CAN SEE 3217 02:28:10,440 --> 02:28:15,560 THE INCREASED ACCURACY OF THE 3218 02:28:15,560 --> 02:28:18,040 PREDICTIONS BUT COMPARED WITH 3219 02:28:18,040 --> 02:28:20,240 OUR DEEP LEARNING MODEL, OUR 3220 02:28:20,240 --> 02:28:26,200 DEEP LEARNING THAT CAPTURED 3221 02:28:26,200 --> 02:28:31,840 THE INTERACTION THAT WE CAN 3222 02:28:31,840 --> 02:28:33,400 HAVE FURTHER ACCURACY. 3223 02:28:33,400 --> 02:28:36,840 SO WE ARE VERY LUCKY THAT MY 3224 02:28:36,840 --> 02:28:40,800 PROGRAM ALLOWS THIS AND ALSO 3225 02:28:40,800 --> 02:28:43,560 THE DATA, HELPED TO CONNECT 3226 02:28:43,560 --> 02:28:47,640 AND ESTABLISH COLLABORATION 3227 02:28:47,640 --> 02:28:48,400 WITH Dr. PERICAK- 3228 02:28:48,400 --> 02:28:49,320 >>Eddie Vance: AT UNIVERSITY 3229 02:28:49,320 --> 02:28:51,000 OF MIAMI. 3230 02:28:51,000 --> 02:28:53,280 AND WE FORTUNATELY GOT THE 3231 02:28:53,280 --> 02:28:55,080 PILOT PROJECT FROM THEM FOR 3232 02:28:55,080 --> 02:28:59,960 ONE YEAR TO STUDY THE 3233 02:28:59,960 --> 02:29:01,480 FEASIBILITY OF STRUCTURE AND 3234 02:29:01,480 --> 02:29:06,880 TO GET AFUL FULL YEAR OF 3235 02:29:06,880 --> 02:29:08,560 AD/ADRD RESEARCH. 3236 02:29:08,560 --> 02:29:11,000 ALTHOUGH WE ANALYZED THE AD 3237 02:29:11,000 --> 02:29:15,440 DATA BEFORE, WE DON'T KNOW HOW 3238 02:29:15,440 --> 02:29:16,840 THAT MATCHES THE 3239 02:29:16,840 --> 02:29:17,720 NEUROPSYCHOLOGICAL FUNCTION OR 3240 02:29:17,720 --> 02:29:19,040 OTHER DATA. 3241 02:29:19,040 --> 02:29:25,600 SO WE TRAINED OUR COMMUNITY 3242 02:29:25,600 --> 02:29:29,040 STAFF AND, NO NOW INVOLVED THE 3243 02:29:29,040 --> 02:29:29,960 CHAIR AND NEUROPSYCHOLOGIST 3244 02:29:29,960 --> 02:29:34,680 INTO OUR TEAM AND THE GOAL WAS 3245 02:29:34,680 --> 02:29:37,600 TO RECRUIT 150 3246 02:29:37,600 --> 02:29:43,760 AFRICAN-AMERICANS AGE 65 AND 3247 02:29:43,760 --> 02:29:49,200 SO FAR HAVE 110 AND HOPE TO 3248 02:29:49,200 --> 02:29:55,240 END THIS SUMMER EARLY AND THIS 3249 02:29:55,240 --> 02:30:03,080 WILL HELP US JOIN TO WORK ON 3250 02:30:03,080 --> 02:30:04,920 AD/ADRD RESEARCH IN LOST 3251 02:30:04,920 --> 02:30:06,200 COHORTS FOCUSED ON MINORITIES. 3252 02:30:06,200 --> 02:30:08,840 AS YOU CAN SEE MANY OF THE 3253 02:30:08,840 --> 02:30:12,360 OLDER WORKS ARE NOT HERE FROM 3254 02:30:12,360 --> 02:30:14,880 MYSELF AND JUST REPRESENT WHAT 3255 02:30:14,880 --> 02:30:18,840 A BIG TEAM, HARD-WORKING GROUP 3256 02:30:18,840 --> 02:30:20,800 AND ALSO SUPPORTIVE PEOPLE 3257 02:30:20,800 --> 02:30:25,600 INCLUDING PEOPLE FROM MY OWN 3258 02:30:25,600 --> 02:30:28,400 INSTITUTE AND WE ARE DEEP IN 3259 02:30:28,400 --> 02:30:29,440 GRATITUDE TO THOSE PEOPLE. 3260 02:30:29,440 --> 02:30:39,880 THANK YOU VERY MUCH. 3261 02:30:40,800 --> 02:30:43,320 >>ALL RIGHT, THANK YOU VERY 3262 02:30:43,320 --> 02:30:45,440 MUCH, Dr. DENG, A TREMENDOUS 3263 02:30:45,440 --> 02:30:46,280 AMOUNT OF RESEARCH YOU ARE 3264 02:30:46,280 --> 02:30:49,160 INVOLVED IN AND GREAT TO SEE A 3265 02:30:49,160 --> 02:30:50,160 SNAPSHOT OF WHAT IS COMING OUT 3266 02:30:50,160 --> 02:30:50,800 OF THAT. 3267 02:30:50,800 --> 02:30:52,800 SO TIME FOR A FEW QUESTIONS 3268 02:30:52,800 --> 02:30:53,720 FROM OUR COUNCIL. 3269 02:30:53,720 --> 02:30:54,800 YES. 3270 02:30:54,800 --> 02:30:56,440 >>SO THAT WAS VERY NICE. 3271 02:30:56,440 --> 02:30:58,800 ONE THING I IT NOTICE AND I 3272 02:30:58,800 --> 02:31:01,960 DON'T KNOW, WE ARE DOING SO 3273 02:31:01,960 --> 02:31:04,840 MANY OMICS ALREADY, BUT THE 3274 02:31:04,840 --> 02:31:06,160 ONE OMICS ALREADY MENTIONED, 3275 02:31:06,160 --> 02:31:09,640 YOU HAVE PLANS TO INCLUDE THAT 3276 02:31:09,640 --> 02:31:11,240 IN THE -- [INAUDIBLE] BECAUSE 3277 02:31:11,240 --> 02:31:14,000 A LOT OF TIMES THE PROTEIN 3278 02:31:14,000 --> 02:31:16,080 LEVELS DON'T FALL IN THE MRNA 3279 02:31:16,080 --> 02:31:18,160 LEVELS AND THE PROTEINS ARE IN 3280 02:31:18,160 --> 02:31:19,440 THE CELL SO WONDER WHERE YOU 3281 02:31:19,440 --> 02:31:21,080 ARE HEADING WITH THAT. 3282 02:31:21,080 --> 02:31:22,040 >> GOOD QUESTION. 3283 02:31:22,040 --> 02:31:30,200 FORTUNATELY WE ARE FUNDED BY 3284 02:31:30,200 --> 02:31:31,640 R01 IN PREVIOUS PROJECT AND BY 3285 02:31:31,640 --> 02:31:38,160 DOING THIS FIND IN 3286 02:31:38,160 --> 02:31:38,960 SIGNIFICANCE YOU MENTION. 3287 02:31:38,960 --> 02:31:42,000 THE COVERAGE AT THAT TIME OVER 3288 02:31:42,000 --> 02:31:44,120 1000 AND THERE ARE HALF A 3289 02:31:44,120 --> 02:31:47,920 MILLION PROTEINS THAT CAN BE 3290 02:31:47,920 --> 02:31:54,760 THERE SO THAT LEADS US TO 3291 02:31:54,760 --> 02:31:57,080 TRANS-OMICS BUT WE HAVE 3292 02:31:57,080 --> 02:32:01,240 RECRUITED A PROFESSOR IN OUR 3293 02:32:01,240 --> 02:32:04,040 DIVISION THAT SPECIALIZES IN 3294 02:32:04,040 --> 02:32:05,440 TRANS-OMICS AND HOPING WITH 3295 02:32:05,440 --> 02:32:06,640 THE CURRENT ANALYSIS WE WILL 3296 02:32:06,640 --> 02:32:09,080 BE ABLE TO DO THAT AND ALSO 3297 02:32:09,080 --> 02:32:12,640 INCREASE TO THE SINGLE CELL. 3298 02:32:12,640 --> 02:32:13,240 THANK YOU. 3299 02:32:13,240 --> 02:32:16,520 >>I HAVE A QUESTION HERE. 3300 02:32:16,520 --> 02:32:18,560 SO THANKS FOR THAT 3301 02:32:18,560 --> 02:32:20,200 COMPREHENSIVE TALK. 3302 02:32:20,200 --> 02:32:22,760 MY QUESTION IS ABOUT YOUR 3303 02:32:22,760 --> 02:32:25,360 OSTEOPOROSIS WORK AND THE 3304 02:32:25,360 --> 02:32:26,320 REALLY NICE TRANSCRIPTION YOU 3305 02:32:26,320 --> 02:32:29,960 GAVE US ON THE STEPS THAT YOU 3306 02:32:29,960 --> 02:32:33,520 USED, EXCUSE ME, TO, YOU KNOW, 3307 02:32:33,520 --> 02:32:35,400 DO THEM IN RANDOMIZATION WORK. 3308 02:32:35,400 --> 02:32:40,400 YOU NEEDED A BIG, BIG SAMPLE 3309 02:32:40,400 --> 02:32:44,160 TO USE ONE STEP IN UK BIOBAND 3310 02:32:44,160 --> 02:32:45,800 AND PROCEEDED IN ALL OF YOUR 3311 02:32:45,800 --> 02:32:46,720 STEPS IN WHITE PEOPLE. 3312 02:32:46,720 --> 02:32:51,360 SO I WANTED TO KNOW SORT OF 3313 02:32:51,360 --> 02:32:54,560 WHETHER AND HOW YOU WOULD 3314 02:32:54,560 --> 02:33:00,880 APPLY THOSE TOOLS TO PEOPLE 3315 02:33:00,880 --> 02:33:03,320 WHO ARE HISPANIC AND NONWHITE. 3316 02:33:03,320 --> 02:33:05,000 AND THEN YOU HINTED AT IT 3317 02:33:05,000 --> 02:33:08,600 LATER ON WITH THE IMPUTATION 3318 02:33:08,600 --> 02:33:11,000 PIECE AND HOW LOCAL ANCESTRY 3319 02:33:11,000 --> 02:33:12,840 MIGHT HELP YOU SOLVE THE 3320 02:33:12,840 --> 02:33:15,000 PROBLEM BUT WANTED TO PLUG 3321 02:33:15,000 --> 02:33:17,280 THAT THE REVOCATION WORK HAS 3322 02:33:17,280 --> 02:33:19,880 BEEN GOING ON IN ALZHEIMER'S 3323 02:33:19,880 --> 02:33:20,680 RESEARCH WORK AS WELL. 3324 02:33:20,680 --> 02:33:22,200 SO A LOT OF THINGS THAT YOU 3325 02:33:22,200 --> 02:33:24,160 SHOWED US COULD BE APPLIED TO 3326 02:33:24,160 --> 02:33:28,360 YOUR NEW AD WORK AS WELL. 3327 02:33:28,360 --> 02:33:36,440 >>THANK YOU. 3328 02:33:36,440 --> 02:33:39,400 YEAH, WE I REALLY DID HALF BUT 3329 02:33:39,400 --> 02:33:45,840 IT IS OUR INTENTION TO APPLY 3330 02:33:45,840 --> 02:33:50,280 OR CATCH RESULTS THAT APPLY TO 3331 02:33:50,280 --> 02:33:51,680 OTHER ETHNIC GROUPS AND USED 3332 02:33:51,680 --> 02:33:54,280 THE IMAGE OF THE CELL SO THAT 3333 02:33:54,280 --> 02:33:58,960 IS WHY WE USE THAT TO ENABLE 3334 02:33:58,960 --> 02:34:01,520 US TO EXTEND TO OTHER GROUPS 3335 02:34:01,520 --> 02:34:02,320 IN THE FUTURE. 3336 02:34:02,320 --> 02:34:04,720 BUT YEAH THAT IS A GREAT 3337 02:34:04,720 --> 02:34:08,120 QUESTION, THANK YOU. 3338 02:34:08,120 --> 02:34:10,400 >>OTHER QUESTIONS? 3339 02:34:10,400 --> 02:34:10,800 SANJAY? 3340 02:34:10,800 --> 02:34:12,800 >>YES, ONE QUICK QUESTION, 3341 02:34:12,800 --> 02:34:14,600 GREAT PROJECT, THANK YOU SO 3342 02:34:14,600 --> 02:34:14,960 MUCH. 3343 02:34:14,960 --> 02:34:17,200 IN YOUR BIOSTUDY WHERE YOU ARE 3344 02:34:17,200 --> 02:34:18,680 RECRUITING, YOU KNOW, ARE YOU 3345 02:34:18,680 --> 02:34:21,760 GOING TO COLLECT SOME CRITICAL 3346 02:34:21,760 --> 02:34:27,040 DATA ON THERE AS FAR AS THE 3347 02:34:27,040 --> 02:34:27,640 BIOMARKER, CELL IMAGING 3348 02:34:27,640 --> 02:34:28,800 BECAUSE THAT IS A GREAT 3349 02:34:28,800 --> 02:34:32,240 OPPORTUNITY FOR YOU TO 3350 02:34:32,240 --> 02:34:34,040 CORRELATE YOUR TRANS-OMICS 3351 02:34:34,040 --> 02:34:35,040 DATA WITH EMPIRICAL DATA. 3352 02:34:35,040 --> 02:34:36,880 >>THANK YOU FOR THIS VERY 3353 02:34:36,880 --> 02:34:38,360 IMPORTANT QUESTION, YES WE DO 3354 02:34:38,360 --> 02:34:39,920 AND SORRY I DIDN'T MENTION 3355 02:34:39,920 --> 02:34:40,760 THAT. 3356 02:34:40,760 --> 02:34:44,000 WE COLLECT SERUM AND PLASMA 3357 02:34:44,000 --> 02:34:46,000 AND GOING TO GIVE THAT TO THE 3358 02:34:46,000 --> 02:34:47,200 UNIVERSITY OF MIAMI AND THEY 3359 02:34:47,200 --> 02:34:49,440 ARE GOING TO DO THE BIOMARKERS 3360 02:34:49,440 --> 02:34:53,800 FOR AB AND ALSO FOR 3361 02:34:53,800 --> 02:34:55,160 CARDIOVASCULAR DISEASE BECAUSE 3362 02:34:55,160 --> 02:35:01,600 CARDIOVASCULAR DISEASE AS YOU 3363 02:35:01,600 --> 02:35:02,920 KNOW IS HIGHLY -- 3364 02:35:02,920 --> 02:35:03,520 [INDISCERNIBLE] 3365 02:35:03,520 --> 02:35:06,400 >>ALL RIGHT THANK YOU VERY 3366 02:35:06,400 --> 02:35:11,320 MUCH, Dr. DENG, GREAT TALK. 3367 02:35:11,320 --> 02:35:17,680 Dr. HODES WILL INTRODUCE OUR 3368 02:35:17,680 --> 02:35:18,120 NEXT SPEAKER. 3369 02:35:18,120 --> 02:35:24,400 >>THANK YOU, GREAT PLEASURE 3370 02:35:24,400 --> 02:35:30,080 TO INTRODUCE OUR GUEST 3371 02:35:30,080 --> 02:35:30,800 SPEAKER, RICK WOYCHIK, 3372 02:35:30,800 --> 02:35:32,960 DIRECTOR OF NATIONAL INSTITUTE 3373 02:35:32,960 --> 02:35:35,120 OF ENVIRONMENTAL HEALTH 3374 02:35:35,120 --> 02:35:35,480 SCIENCES. 3375 02:35:35,480 --> 02:35:38,520 I HAD THE PLEASURE TO VISIT 3376 02:35:38,520 --> 02:35:40,560 THEIR COUNCIL AND Dr. 3377 02:35:40,560 --> 02:35:42,520 WOYCHIK ABLE TO SIP KATE. 3378 02:35:42,520 --> 02:35:44,560 VIEW ON THE LAKE IS QUITE 3379 02:35:44,560 --> 02:35:46,600 NICE, WE HAVE THE OCCASIONAL 3380 02:35:46,600 --> 02:35:48,080 PUDDLE HERE BUT NOTHING MUCH 3381 02:35:48,080 --> 02:35:48,560 MORE. 3382 02:35:48,560 --> 02:35:51,440 WE HAD OUR LUNCH OUT ON THE 3383 02:35:51,440 --> 02:35:53,280 VERANDA ON A BEAUTIFUL SPRING 3384 02:35:53,280 --> 02:35:55,920 DAY, HERE WE HAVE A BOX LUNCH 3385 02:35:55,920 --> 02:35:57,560 BUT IT HAS BEEN A GREAT 3386 02:35:57,560 --> 02:35:58,720 PLEASURE TO WORK WITH RICK 3387 02:35:58,720 --> 02:36:00,160 OVER THE YEARS IN HIS 3388 02:36:00,160 --> 02:36:00,560 CAPACITY. 3389 02:36:00,560 --> 02:36:05,160 HE HAS BEEN A GREAT LEADER IN 3390 02:36:05,160 --> 02:36:06,440 THE ENVIRONMENTAL EXPOSURE, 3391 02:36:06,440 --> 02:36:07,680 TAKING ON A GREAT SIGNIFICANCE 3392 02:36:07,680 --> 02:36:09,720 TO ALL OF US AND HE HAS PLAYED 3393 02:36:09,720 --> 02:36:11,040 A LEADING ROLE THERE. 3394 02:36:11,040 --> 02:36:13,440 IN THE EPISODE OF COVID, HE 3395 02:36:13,440 --> 02:36:15,360 HAD BEEN CO-CHAIRING THE RADX 3396 02:36:15,360 --> 02:36:17,240 EFFORT WHICH I HAD A 3397 02:36:17,240 --> 02:36:17,960 OPPORTUNITY TO PARTICIPATE IN 3398 02:36:17,960 --> 02:36:22,160 AS WELL SO ACROSS THE SPECTRUM 3399 02:36:22,160 --> 02:36:23,800 OF THE INTELLECTUAL SCIENTIFIC 3400 02:36:23,800 --> 02:36:25,160 ACTION AT YOU ARE A LEVEL AND 3401 02:36:25,160 --> 02:36:28,360 OF COURSE STAFF HAVE BEEN 3402 02:36:28,360 --> 02:36:30,160 EXTRAORDINARY AND A GREAT 3403 02:36:30,160 --> 02:36:31,440 PLEASURE TO TALK TODAY ABOUT 3404 02:36:31,440 --> 02:36:32,280 THE EXPOSOME IN AGING, HUMAN 3405 02:36:32,280 --> 02:36:33,000 HEALTH AND DISEASE. 3406 02:36:33,000 --> 02:36:34,120 THAT SORT OF COVERS IT. 3407 02:36:34,120 --> 02:36:35,200 RICK? 3408 02:36:35,200 --> 02:36:36,040 >>THANKS VERY MUCH 3409 02:36:36,040 --> 02:36:37,120 RICHARD FOR THIS INVITE TO BE 3410 02:36:37,120 --> 02:36:38,400 HERE AND WHAT I WOULD LIKE TO 3411 02:36:38,400 --> 02:36:39,800 DO IS TALK ABOUT SOME OF THE 3412 02:36:39,800 --> 02:36:44,200 WORK WE ARE DOING AT NIEHS AND 3413 02:36:44,200 --> 02:36:45,480 HOPEFULLY THIS WILL BE AN 3414 02:36:45,480 --> 02:36:48,400 ATTEMPT TO BRING MORE 3415 02:36:48,400 --> 02:36:49,120 ENVIRONMENTAL INFLUENCES AND 3416 02:36:49,120 --> 02:36:50,480 INTEGRATE THEM INTO THE FABRIC 3417 02:36:50,480 --> 02:36:54,240 OF THE WORK WE DO AT NIA. 3418 02:36:54,240 --> 02:36:58,000 SO HOW DO I ADVANCE HERE? 3419 02:36:58,000 --> 02:37:01,840 OKAY, I GUESS I DO. 3420 02:37:01,840 --> 02:37:06,640 LET ME START OFF WITH THE 3421 02:37:06,640 --> 02:37:08,880 MISSION. 3422 02:37:08,880 --> 02:37:13,000 IN THE UPPER LEFT, NI HE HS -- 3423 02:37:13,000 --> 02:37:14,880 THERE WE ARE, THE MISSION IS 3424 02:37:14,880 --> 02:37:16,120 TO DISCOVER HOW THE 3425 02:37:16,120 --> 02:37:17,160 ENVIRONMENT AFFECTS PEOPLE IN 3426 02:37:17,160 --> 02:37:21,840 ORDER TO PROMOTE HEALTHIER 3427 02:37:21,840 --> 02:37:23,920 LIVES AND THE VISION TO 3428 02:37:23,920 --> 02:37:26,480 PROVIDE GLOBAL LEADERSHIP FOR 3429 02:37:26,480 --> 02:37:27,600 INNOVATIVE RESEARCH THAT 3430 02:37:27,600 --> 02:37:29,240 IMPROVES PUBLIC HEALTH BY 3431 02:37:29,240 --> 02:37:30,640 PREVENTING DISEASE AND 3432 02:37:30,640 --> 02:37:31,080 DISABILITY. 3433 02:37:31,080 --> 02:37:31,920 THE MOST IMPORTANT PART OF 3434 02:37:31,920 --> 02:37:33,680 THAT IS THE PREVENTION PART SO 3435 02:37:33,680 --> 02:37:36,200 THEN WE HOPE TO BE WORKING 3436 02:37:36,200 --> 02:37:38,440 WITH ALL OF YOU FOR THE 3437 02:37:38,440 --> 02:37:40,680 PREDISPOSING TYPE OF 3438 02:37:40,680 --> 02:37:42,880 AGE-RELATED DISEASES THAT 3439 02:37:42,880 --> 02:37:43,560 IMPACT HUMAN HEALTH. 3440 02:37:43,560 --> 02:37:45,040 THE PLAN HAS THREE DIFFERENT 3441 02:37:45,040 --> 02:37:45,480 THEMES. 3442 02:37:45,480 --> 02:37:46,920 ON THE LEFT IS THE 3443 02:37:46,920 --> 02:37:48,000 ENVIRONMENTAL HEALTH SCIENCES 3444 02:37:48,000 --> 02:37:51,400 AND WHAT THAT MEANS IS WE ARE 3445 02:37:51,400 --> 02:37:55,160 STUDYING AND DECIPHERING THE 3446 02:37:55,160 --> 02:37:56,520 BIOLOGICAL PATHWAYS THAT DRIVE 3447 02:37:56,520 --> 02:37:58,280 HUMAN PATHOLOGY AND WE WANT TO 3448 02:37:58,280 --> 02:37:59,600 UNDERSTAND HOW DIFFERENT 3449 02:37:59,600 --> 02:38:01,240 ELEMENTS OF THE ENVIRONMENT 3450 02:38:01,240 --> 02:38:02,720 CAN BE IMPACTING THOSE 3451 02:38:02,720 --> 02:38:03,360 NETWORKS. 3452 02:38:03,360 --> 02:38:06,120 ON THE RIGHT, WE SEE 3453 02:38:06,120 --> 02:38:06,880 DATA-TO-KNOWLEDGE ACTION WHERE 3454 02:38:06,880 --> 02:38:09,120 WE HOPE TO TAKE THE 3455 02:38:09,120 --> 02:38:10,360 INFORMATION WE HAVE GENERATE 3456 02:38:10,360 --> 02:38:12,440 AND PUT IT INTO PRACTICE FOR 3457 02:38:12,440 --> 02:38:20,680 THE BENEFIT OF PUBLIC HEALTH 3458 02:38:20,680 --> 02:38:24,000 AND THE THIRD THEME, 3459 02:38:24,000 --> 02:38:24,880 SCIENTIFIC STEWARDSHIP AND 3460 02:38:24,880 --> 02:38:26,400 SUPPORT, THE THIRD TEAM, WE 3461 02:38:26,400 --> 02:38:29,520 WANT TO MAKE SURE WE'RE 3462 02:38:29,520 --> 02:38:33,920 SHARING THAT WITH OTHER 3463 02:38:33,920 --> 02:38:36,560 SCIENTISTS AND COLLABORATING 3464 02:38:36,560 --> 02:38:37,960 WITH THE COMMUNITY. 3465 02:38:37,960 --> 02:38:40,280 SO THAT IS THE MISSION AND 3466 02:38:40,280 --> 02:38:42,120 VISION FOR NOW AND WE WILL 3467 02:38:42,120 --> 02:38:44,000 STICK WITH THESE THREE TEAMS 3468 02:38:44,000 --> 02:38:45,320 BUT THROUGH THE COMING MONTHS 3469 02:38:45,320 --> 02:38:47,960 WE WILL BE UPDATING WITH GOALS 3470 02:38:47,960 --> 02:38:50,040 ASK STRATEGIES SO BY THIS TIME 3471 02:38:50,040 --> 02:38:53,760 NEXT YEAR, YOU WILL SEE WHAT 3472 02:38:53,760 --> 02:38:55,440 OUR NEW STRATEGIC PLAN LOOKS 3473 02:38:55,440 --> 02:38:57,480 LIKE. 3474 02:38:57,480 --> 02:39:02,320 LET ME START WITH -- DO I 3475 02:39:02,320 --> 02:39:05,440 POINT TO THE COMPUTER? 3476 02:39:05,440 --> 02:39:10,600 OVER HERE? 3477 02:39:10,600 --> 02:39:11,560 THANK YOU. 3478 02:39:11,560 --> 02:39:13,000 [LAUGHTER] AT YOU? 3479 02:39:13,000 --> 02:39:15,560 >>NO, DON'T POINT AT ME. 3480 02:39:15,560 --> 02:39:16,240 [LAUGHTER] 3481 02:39:16,240 --> 02:39:18,280 >>THERE WE ARE, GREAT. 3482 02:39:18,280 --> 02:39:19,760 SO THIS IS STILL DEVELOPING 3483 02:39:19,760 --> 02:39:22,120 BUT I WANT TO BE CLEAR THAT 3484 02:39:22,120 --> 02:39:23,840 THERE ARE SCIENTIFIC PRIORITY 3485 02:39:23,840 --> 02:39:26,160 AREAS THAT WILL EMERGE AND BE 3486 02:39:26,160 --> 02:39:27,520 INTEGRATED INTO OUR NEW 3487 02:39:27,520 --> 02:39:28,440 STRATEGIC PLAN AND THAT IS 3488 02:39:28,440 --> 02:39:29,080 SHOWN HERE. 3489 02:39:29,080 --> 02:39:32,920 THESE ARE ALL KIND OF ENTER 3490 02:39:32,920 --> 02:39:35,640 DEPEND DENT WITH EACH OTHER, 3491 02:39:35,640 --> 02:39:39,000 WE HAVE CLIMATE CHANGE AND 3492 02:39:39,000 --> 02:39:41,160 HEALTH, ENVIRONMENTAL JUSTICE 3493 02:39:41,160 --> 02:39:44,040 AND HEALTH DISPARITIES, 3494 02:39:44,040 --> 02:39:48,280 COMPUTATIONAL BIOLOGY AND DATA 3495 02:39:48,280 --> 02:39:50,640 SCIENCE, THE EXPOSOME, THE 3496 02:39:50,640 --> 02:39:52,760 PRECISION ENVIRONMENTAL HEALTH 3497 02:39:52,760 --> 02:39:54,760 AND MECHANIC CAN FIFTH TICK 3498 02:39:54,760 --> 02:39:55,480 AND TRANSLATIONAL TOXICOLOGY. 3499 02:39:55,480 --> 02:39:57,480 I CAN'T TALK ABOUT ALL OF 3500 02:39:57,480 --> 02:40:01,680 THESE TODAY BUT THERE IS GREAT 3501 02:40:01,680 --> 02:40:04,160 INTEREST IN THE ENVIRONMENTAL 3502 02:40:04,160 --> 02:40:05,520 HEALTH AND WILL TELL YOU ABOUT 3503 02:40:05,520 --> 02:40:07,400 THE INITIATIVES WE ARE DOING 3504 02:40:07,400 --> 02:40:10,920 ON A CLIMATE-WIDE SCALE. 3505 02:40:10,920 --> 02:40:18,080 SO LETS START ON THE EXPOS 3506 02:40:18,080 --> 02:40:19,160 OME. 3507 02:40:19,160 --> 02:40:23,200 THIS SLIDE AT NIEHS REPRESENTS 3508 02:40:23,200 --> 02:40:24,400 WHAT IS IN THE ENVIRONMENT 3509 02:40:24,400 --> 02:40:26,480 THAT CAN IMPACT OUR HEALTH. 3510 02:40:26,480 --> 02:40:30,440 IT IS NOT JUST ABOUT THE AIR, 3511 02:40:30,440 --> 02:40:32,320 WATER AND SOIL, WE ALSO HAVE 3512 02:40:32,320 --> 02:40:35,400 TO BE CONCERNED ABOUT THE 3513 02:40:35,400 --> 02:40:37,960 AGRICULTURAL CHEMICALS AND 3514 02:40:37,960 --> 02:40:38,520 PESTICIDES, SYNTHETIC 3515 02:40:38,520 --> 02:40:38,920 MATERIALS. 3516 02:40:38,920 --> 02:40:40,280 YOU HAVE TO BE CAREFUL ABOUT 3517 02:40:40,280 --> 02:40:42,720 THOSE THINGS. 3518 02:40:42,720 --> 02:40:44,800 WE ALSO STUDY THE EFFECTS OF 3519 02:40:44,800 --> 02:40:46,320 THE DISASTERS AND WILDFIRES 3520 02:40:46,320 --> 02:40:48,240 BUT WHAT WE COME TO RECOGNIZE 3521 02:40:48,240 --> 02:40:50,000 IS IF WE TRULY WANT TO 3522 02:40:50,000 --> 02:40:51,520 UNDERSTAND THE IMPACT OF THE 3523 02:40:51,520 --> 02:40:52,800 ENVIRONMENT, IT CAN'T BE BY 3524 02:40:52,800 --> 02:40:55,480 LOOKING AT ONE OF THESE THINGS 3525 02:40:55,480 --> 02:40:55,880 ALONE. 3526 02:40:55,880 --> 02:40:58,600 SO WHAT DOES THIS EMERGE IS 3527 02:40:58,600 --> 02:41:03,240 THE CONCEPT OF THE EXPOSOME 3528 02:41:03,240 --> 02:41:04,600 AND WAS ORIGINALLY DESCRIBED 3529 02:41:04,600 --> 02:41:09,000 BY CHRIS WELLS ABOUT THE 3530 02:41:09,000 --> 02:41:11,080 TOTALITY OF EXPOSURE OVER THE 3531 02:41:11,080 --> 02:41:14,360 LIFE COURSE SO WE ARE LOOKING 3532 02:41:14,360 --> 02:41:18,320 AT THAT HOW THIS PREDISPOSES 3533 02:41:18,320 --> 02:41:18,640 HEALTH. 3534 02:41:18,640 --> 02:41:21,440 SO IT IS NOT JUST ABOUT 3535 02:41:21,440 --> 02:41:23,360 STUDYING PESTICIDES OR AIR 3536 02:41:23,360 --> 02:41:27,600 POLLUTION OR A PARTICULAR 3537 02:41:27,600 --> 02:41:28,600 PLASTICIZERS, WE HAVE TO BE 3538 02:41:28,600 --> 02:41:30,400 DOING ALL THESE THINGS AND 3539 02:41:30,400 --> 02:41:32,040 FURTHERMORE IT IS NOT JUST 3540 02:41:32,040 --> 02:41:35,080 ABOUT THE CHEMICAL AND 3541 02:41:35,080 --> 02:41:38,880 PHYSICAL ELMENTS OF THE 3542 02:41:38,880 --> 02:41:41,120 EXPOSOME, WE HAVE TO LOOK AT 3543 02:41:41,120 --> 02:41:42,960 THE VARY VALUES SO IF WE'RE 3544 02:41:42,960 --> 02:41:46,160 TRULY GOING TO BE LOOKING AT 3545 02:41:46,160 --> 02:41:48,480 THE TOTALITY OF COMPOSURE, HOW 3546 02:41:48,480 --> 02:41:49,960 DO WE DO THIS? 3547 02:41:49,960 --> 02:41:52,760 BECAUSE THIS IS TRULY COMPLEX. 3548 02:41:52,760 --> 02:41:58,800 INTEGRATING ACROSS THE ENTIRE 3549 02:41:58,800 --> 02:41:59,960 SPECTRUM AND INCLUDING 3550 02:41:59,960 --> 02:42:00,760 EXTERNAL AND INTERNAL 3551 02:42:00,760 --> 02:42:02,520 EXPOSURES, IT IS NOT EASY. 3552 02:42:02,520 --> 02:42:05,040 SO WHAT WE DID LAST SUMMER IS 3553 02:42:05,040 --> 02:42:06,600 INVITED Dr. JERRY MILLER ONE 3554 02:42:06,600 --> 02:42:09,880 OF OUR GRANTE ES, ACTUALLY ON 3555 02:42:09,880 --> 02:42:12,520 THE FACULTY AT COLUMBIA AND HE 3556 02:42:12,520 --> 02:42:14,400 HAS BEEN LOOKING AT ECONOMIC 3557 02:42:14,400 --> 02:42:17,120 SCIENCE THE PAST DECADE OR SO. 3558 02:42:17,120 --> 02:42:19,320 SO HE GAVE A PRESENTATION FOR 3559 02:42:19,320 --> 02:42:21,160 THE COUNCIL AND CHALLENGED US 3560 02:42:21,160 --> 02:42:23,800 WE NEED TO COME UP WITH AN 3561 02:42:23,800 --> 02:42:26,880 OPERATIONAL DEFINITION OF THE 3562 02:42:26,880 --> 02:42:27,560 EXPOSOME. 3563 02:42:27,560 --> 02:42:30,160 WHAT IS IT AND WHAT DOES IT 3564 02:42:30,160 --> 02:42:30,520 MATTER? 3565 02:42:30,520 --> 02:42:32,360 HE SAID WE WILL HAVE TO BUILD 3566 02:42:32,360 --> 02:42:34,600 TECHNOLOGY TO STUDY THE 3567 02:42:34,600 --> 02:42:35,840 EXPOSOME BECAUSE WE CURRENTLY 3568 02:42:35,840 --> 02:42:38,080 HAVE THE TOOLS BUT NOT THE 3569 02:42:38,080 --> 02:42:41,200 TECHNOLOGY TO TRULY CAPTURE 3570 02:42:41,200 --> 02:42:42,840 THE EXPOSOME BUT HE ALSO 3571 02:42:42,840 --> 02:42:45,080 ADVOCATED FOR WHAT HE CALLED 3572 02:42:45,080 --> 02:42:47,240 THE TAG AUTOMATIC EXPOSOME. 3573 02:42:47,240 --> 02:42:48,920 THERE ARE THINGS WE CAN DO 3574 02:42:48,920 --> 02:42:53,720 EVEN IN TALKING ABOUT THESE 3575 02:42:53,720 --> 02:42:54,720 THINGS WITH EXPERIMENTAL 3576 02:42:54,720 --> 02:42:55,080 DESIGN. 3577 02:42:55,080 --> 02:42:58,320 SO HE LIKE KENNED THIS TO WHAT 3578 02:42:58,320 --> 02:43:02,080 HAS HAPPENED IN THE GENOMIC 3579 02:43:02,080 --> 02:43:07,760 COMMUNITY IN THE PAST DECADE. 3580 02:43:07,760 --> 02:43:12,480 WHEN GENOMICS STARTED, THEY 3581 02:43:12,480 --> 02:43:14,440 LOOKED AT LOOKING AT A GENE IN 3582 02:43:14,440 --> 02:43:16,160 TIME AND I CAN REMEMBER 3583 02:43:16,160 --> 02:43:17,920 LOOKING AT THE GENE IN A 3584 02:43:17,920 --> 02:43:20,240 MICROPHONE AND THOSE WERE 3585 02:43:20,240 --> 02:43:21,880 PRETTY PRIMITIVE WITH THE 3586 02:43:21,880 --> 02:43:24,760 WHOLE TECHNOLOGY WE HAVE WITH 3587 02:43:24,760 --> 02:43:26,640 SEQUENCING A GENOME SO LET'S 3588 02:43:26,640 --> 02:43:30,280 START WITH THE PRAGMATIC 3589 02:43:30,280 --> 02:43:34,440 REVIEW OF THE EXPOSOME. 3590 02:43:34,440 --> 02:43:36,320 NIEHS SPONSORED A SERIES OF 3591 02:43:36,320 --> 02:43:37,120 WORKSHOPS LAST SUMMER AND I 3592 02:43:37,120 --> 02:43:40,560 HOPE SOME OF YOU WERE PART OF 3593 02:43:40,560 --> 02:43:42,120 THESE WORKSHOPS BECAUSE WE 3594 02:43:42,120 --> 02:43:44,320 WANT TO DETERMINE WHAT DO WE 3595 02:43:44,320 --> 02:43:46,280 MEASURE, WHEN, HOW DO WE 3596 02:43:46,280 --> 02:43:48,040 MEASURE, WHAT DO WE MEASURE, 3597 02:43:48,040 --> 02:43:50,600 WHAT ARE THE TECHNOLOGIES WE 3598 02:43:50,600 --> 02:43:53,080 USE TO TRULY CAPTURE THE 3599 02:43:53,080 --> 02:43:55,000 EXPOSOME AND THEN HOW DO WE 3600 02:43:55,000 --> 02:43:56,880 SHARE AND TRANSLATE THE DATA 3601 02:43:56,880 --> 02:43:58,720 TO HAVE AN IMPACT IN HEALTH 3602 02:43:58,720 --> 02:44:00,280 AND DISEASE? 3603 02:44:00,280 --> 02:44:05,360 SO THE FINAL REPORTS FROM 3604 02:44:05,360 --> 02:44:06,720 THESE WORKSHOPS, DOCUMENTS THE 3605 02:44:06,720 --> 02:44:08,280 64 DIFFERENT ISSUES AND IF YOU 3606 02:44:08,280 --> 02:44:10,040 ARE INTERESTED, ALL OF THESE 3607 02:44:10,040 --> 02:44:11,240 WORKSHOPS WERE RECORDED. 3608 02:44:11,240 --> 02:44:12,520 YOU CAN TAKE A LOOK AT THEM, 3609 02:44:12,520 --> 02:44:13,720 READ THROUGH THE MINUTES BUT 3610 02:44:13,720 --> 02:44:15,640 ONE THING THAT WAS ABUNDANTLY 3611 02:44:15,640 --> 02:44:18,280 CLEAR IS WE NEED A 3612 02:44:18,280 --> 02:44:20,200 COORDINATION EFFORT. 3613 02:44:20,200 --> 02:44:23,360 SO THE CONCEPT OF THE 3614 02:44:23,360 --> 02:44:28,560 GLOBALIST RESEARCH AND 3615 02:44:28,560 --> 02:44:30,280 COORDINATION WITH ACCELERATING 3616 02:44:30,280 --> 02:44:31,240 PRECISION ENVIRONMENTAL HELP 3617 02:44:31,240 --> 02:44:32,400 CAME OUT OF THIS. 3618 02:44:32,400 --> 02:44:35,960 YOU WILL BE SEEING AN RFA AT 3619 02:44:35,960 --> 02:44:37,440 SOME POINT, NOT TOMORROW BUT 3620 02:44:37,440 --> 02:44:41,840 OVER THE COURSE OF SEVERAL 3621 02:44:41,840 --> 02:44:45,160 MONTHS TO DEVELOP A 3622 02:44:45,160 --> 02:44:49,400 COMMONLY-AGREED UPON FRAMEWORK 3623 02:44:49,400 --> 02:44:50,560 FOR EXPOSOMICS, PROPOSAL BEST 3624 02:44:50,560 --> 02:44:51,680 PRACTICE IN DATA COLLECTION 3625 02:44:51,680 --> 02:44:55,720 AND SHARING AND BUILD A GLOBAL 3626 02:44:55,720 --> 02:44:57,040 EXPOSOME RESEARCH COMMUNITY OF 3627 02:44:57,040 --> 02:45:00,760 DIVERSITY AND INCLUSION TO 3628 02:45:00,760 --> 02:45:02,880 FOSTER NATIONAL AND 3629 02:45:02,880 --> 02:45:03,880 INTERNATIONAL COLLABORATIONS. 3630 02:45:03,880 --> 02:45:07,520 THE FIRST RESEARCH SCOPE IS TO 3631 02:45:07,520 --> 02:45:12,360 DEVELOP A COMMONLY-AGREED UPON 3632 02:45:12,360 --> 02:45:13,360 CONCEPTUAL FRAMEWORK TO 3633 02:45:13,360 --> 02:45:17,280 ADDRESS FUNDAMENTAL QUESTIONS 3634 02:45:17,280 --> 02:45:21,680 IN EXPOSOMICS, THEN IDENTIFY 3635 02:45:21,680 --> 02:45:23,840 AGREED-UPON TECHNOLOGIES AND 3636 02:45:23,840 --> 02:45:25,400 PROMOTE BEST PRACTICE AND 3637 02:45:25,400 --> 02:45:28,600 FINALLY BUILD A GLOBAL 3638 02:45:28,600 --> 02:45:32,240 EXPOSOME RESEARCH COMMUNITY 3639 02:45:32,240 --> 02:45:33,880 AND FOSTER NATIONAL AND 3640 02:45:33,880 --> 02:45:35,200 INTERNATIONAL COLLABORATIONS. 3641 02:45:35,200 --> 02:45:35,600 NEXT SLIDE. 3642 02:45:35,600 --> 02:45:46,160 THE OTHER HAND WE HAVE THIS 3643 02:45:46,800 --> 02:45:50,960 GLOBAL EXPOSOME, NEXT SLIDE, 3644 02:45:50,960 --> 02:45:55,320 OF IMPLEMENTING EXPOS OME IN 3645 02:45:55,320 --> 02:45:56,320 ENVIRONMENTAL HEALTH RESEARCH, 3646 02:45:56,320 --> 02:45:58,640 WE DID THIS AT MOUNT SINAI AND 3647 02:45:58,640 --> 02:46:02,720 IF YOU ARE A NIH INVESTIGATOR, 3648 02:46:02,720 --> 02:46:03,920 YOU CAN SEND YOUR SAMPLES OFF. 3649 02:46:03,920 --> 02:46:07,640 IF YOU WANT TO KNOW ABOUT CADM 3650 02:46:07,640 --> 02:46:10,040 IUM EXPOSURE, WE CAN DO THAT 3651 02:46:10,040 --> 02:46:11,480 BUT MOST IMPORTANTLY THIS IS 3652 02:46:11,480 --> 02:46:13,120 THE SUMMER TORE ANALYSIS 3653 02:46:13,120 --> 02:46:20,360 LOOKING AT THE TOTALITY OF THE 3654 02:46:20,360 --> 02:46:20,800 COMPOSURE. 3655 02:46:20,800 --> 02:46:23,280 SO AS I GO ON HERE, WE WANT TO 3656 02:46:23,280 --> 02:46:26,840 LOOK AT THE CONCEPT OF 3657 02:46:26,840 --> 02:46:27,480 PRECISION ENVIRONMENTAL 3658 02:46:27,480 --> 02:46:27,800 HEALTH. 3659 02:46:27,800 --> 02:46:30,280 THREE OF OUR GRANTEES GAVE A 3660 02:46:30,280 --> 02:46:32,920 PRESENTATION TO OUR COUNCIL 3661 02:46:32,920 --> 02:46:35,840 MEETING, ONE FROM BAYLOR WHO 3662 02:46:35,840 --> 02:46:37,920 DISCUSSED THIS CONCEPT OF 3663 02:46:37,920 --> 02:46:38,640 PRECISION ENVIRONMENTAL HEALTH 3664 02:46:38,640 --> 02:46:40,880 AND WHAT THIS IS ALL ABOUT IS 3665 02:46:40,880 --> 02:46:42,240 A RESEARCH STRATEGY TO 3666 02:46:42,240 --> 02:46:43,880 RECOGNIZE THAT DIFFERENT 3667 02:46:43,880 --> 02:46:46,160 PEOPLE RESPOND TO 3668 02:46:46,160 --> 02:46:47,160 ENVIRONMENTAL EXPOSURES IN 3669 02:46:47,160 --> 02:46:48,520 DIFFERENT WAYS. 3670 02:46:48,520 --> 02:46:50,240 SO WHAT MAY BE HARMFUL TO ONE 3671 02:46:50,240 --> 02:46:51,880 PERSON MAY NOT BE HARMFUL TO 3672 02:46:51,880 --> 02:46:52,200 ANOTHER. 3673 02:46:52,200 --> 02:46:54,760 WE HAVE TO FIGURE THIS OUT. 3674 02:46:54,760 --> 02:46:58,160 THIS COMPMENTS THE PRECISION 3675 02:46:58,160 --> 02:47:01,200 MEDICINE PROGRAM WHERE WE CAN 3676 02:47:01,200 --> 02:47:06,280 SEE SEQUENCING FINE HOME IN 3677 02:47:06,280 --> 02:47:08,440 VARIATION FOR THERAPEUTIC 3678 02:47:08,440 --> 02:47:10,840 INTERVENTIONS OR DIFFERENT 3679 02:47:10,840 --> 02:47:11,640 DISEASE OUTCOMES. 3680 02:47:11,640 --> 02:47:14,880 BUT THIS IS ALSO ABOUT THE 3681 02:47:14,880 --> 02:47:15,680 ENVIRONMENTAL EFFECTS SO WHAT 3682 02:47:15,680 --> 02:47:19,240 ARE THE GENES AND EPIGENETIC 3683 02:47:19,240 --> 02:47:20,920 CHANGES THAT MAY BE 3684 02:47:20,920 --> 02:47:23,880 INTERACTING WITH THE 3685 02:47:23,880 --> 02:47:24,720 ENVIRONMENTAL EXPOSOME. 3686 02:47:24,720 --> 02:47:26,680 SO THE GOAL HERE IS TO 3687 02:47:26,680 --> 02:47:29,560 UNDERSTAND INDIVIDUAL RISK TO 3688 02:47:29,560 --> 02:47:30,080 PREVENT DISEASE. 3689 02:47:30,080 --> 02:47:32,600 SHARON SEPARATED IT IS VERY 3690 02:47:32,600 --> 02:47:37,920 SIMPLE, IT IS GXEXD BUT THE G 3691 02:47:37,920 --> 02:47:39,040 PART IS COMPLICATED BECAUSE 3692 02:47:39,040 --> 02:47:40,840 THERE IS NO SINGLE AGAIN OR 3693 02:47:40,840 --> 02:47:49,560 VARIATION WITHIN A GENE THAT 3694 02:47:49,560 --> 02:47:51,200 PREDISPOSES TO AIR POLLUTION. 3695 02:47:51,200 --> 02:47:52,360 THESE ARE COMPLEX TRAITS AND 3696 02:47:52,360 --> 02:47:56,120 THIS IS JUST LIKE THE GENETICS 3697 02:47:56,120 --> 02:47:57,920 OF MOST COMMON DISEASES SO 3698 02:47:57,920 --> 02:48:01,240 THERE'S NOT A SINGLE GENE BUT 3699 02:48:01,240 --> 02:48:02,480 POTENTIALLY HUNDREDS OF 3700 02:48:02,480 --> 02:48:05,880 THOUSANDS OF DIFFERENT GENES 3701 02:48:05,880 --> 02:48:08,520 THEREIN THAT WILL COLLABORATE 3702 02:48:08,520 --> 02:48:10,440 TO A GENETIC PREDISPOSITION. 3703 02:48:10,440 --> 02:48:12,080 SO FOR THIS REASON WE NOW THE 3704 02:48:12,080 --> 02:48:14,520 IT WOULD BE GOOD TO MAYBE 3705 02:48:14,520 --> 02:48:19,880 COLLABORATE WITH THIS NEW 3706 02:48:19,880 --> 02:48:23,440 EMERGING COLLABORATIVE EFFORT 3707 02:48:23,440 --> 02:48:26,080 CALLED THE INTERNATIONAL 3708 02:48:26,080 --> 02:48:26,680 COMMON DECEMBER ALIGNS. 3709 02:48:26,680 --> 02:48:28,520 AND MAYBE SOME OF YOU WERE 3710 02:48:28,520 --> 02:48:35,880 WITH ME WHEN FRANCIS COLLINS 3711 02:48:35,880 --> 02:48:37,760 LAUNCHED THIS. 3712 02:48:37,760 --> 02:48:39,200 AND IN ADDRESSING COMPLEX 3713 02:48:39,200 --> 02:48:43,200 TRAITS, WE SHOULD BE WORKING 3714 02:48:43,200 --> 02:48:44,440 COLLABORATIVELY TOGETHER SO 3715 02:48:44,440 --> 02:48:47,000 THE COHORTS IN ICELAND AND 3716 02:48:47,000 --> 02:48:49,280 OTHER PLACES SHOULD BE 3717 02:48:49,280 --> 02:48:52,640 SEAMLESSLY INTEGRATED TOGETHER 3718 02:48:52,640 --> 02:48:57,880 TO FIGURE OUT WHAT THE HUGE 3719 02:48:57,880 --> 02:49:00,360 COHORTS ARE. 3720 02:49:00,360 --> 02:49:04,240 SO WE ARE WORKING TOGETHER TO 3721 02:49:04,240 --> 02:49:07,440 ELIMINATE THE WAY THE ICD A 3722 02:49:07,440 --> 02:49:11,560 AND OTHER LARGE TEN NET TICKS 3723 02:49:11,560 --> 02:49:12,480 AND EPIGENETICS CENTERS 3724 02:49:12,480 --> 02:49:14,680 COLLECT DATA AND FURTHERMORE, 3725 02:49:14,680 --> 02:49:18,480 LET'S DO SOME METHYLATION 3726 02:49:18,480 --> 02:49:22,560 CHANGES THAT MAY BE ASSOCIATED 3727 02:49:22,560 --> 02:49:30,520 WITH A PHENOTYPE OF DISEASE 3728 02:49:30,520 --> 02:49:33,160 INCLUDING EXPOSOMIC AND 3729 02:49:33,160 --> 02:49:33,720 EPIGENETICS. 3730 02:49:33,720 --> 02:49:36,280 SO WE DID THIS BY REACHING OUT 3731 02:49:36,280 --> 02:49:39,520 TO THE ICD A AND MANY OF YOU 3732 02:49:39,520 --> 02:49:43,720 KNOW ABOUT THIS, THE ALL OF US 3733 02:49:43,720 --> 02:49:45,560 RESEARCH PROGRAM, TO REACH OUT 3734 02:49:45,560 --> 02:49:47,600 TO ONE MILLION PEOPLE LIVING 3735 02:49:47,600 --> 02:49:50,560 IN THE U.S. 3736 02:49:50,560 --> 02:49:53,840 VERY SUPPORTIVE OF THIS NOTION 3737 02:49:53,840 --> 02:49:58,680 OF INTEGRATING ENVIRONMENTAL 3738 02:49:58,680 --> 02:50:00,880 EXPOSURE INTO THE RESEARCH. 3739 02:50:00,880 --> 02:50:04,680 SO THE EMPHASIS IS ON GENOMICS 3740 02:50:04,680 --> 02:50:05,840 AND BIOSPECIMENS, HEALTH 3741 02:50:05,840 --> 02:50:06,640 RECORDS BUT FORTUNATELY NOW 3742 02:50:06,640 --> 02:50:08,720 THEY ARE WORKING WITH US TO 3743 02:50:08,720 --> 02:50:11,440 INTEGRATE THAT MISSING PIECE 3744 02:50:11,440 --> 02:50:13,520 OF THE PIE WHICH IS THE 3745 02:50:13,520 --> 02:50:14,360 ENVIRONMENTAL DATA. 3746 02:50:14,360 --> 02:50:19,360 SO IF WE HAVE IN PLACE AND 3747 02:50:19,360 --> 02:50:21,800 ACTUALLY RICHARD WAS PART OF 3748 02:50:21,800 --> 02:50:25,560 THIS IN THE ALL OF US BRAIN 3749 02:50:25,560 --> 02:50:28,440 TRUST LAST WEEK, WE HAVE THREE 3750 02:50:28,440 --> 02:50:29,040 PHASES. 3751 02:50:29,040 --> 02:50:30,400 THE KWEURS IS TO GET ADDRESS 3752 02:50:30,400 --> 02:50:31,440 INFORMATION WHERE SOMEONE 3753 02:50:31,440 --> 02:50:33,120 LIVES, WHERE THEY WORK, WHERE 3754 02:50:33,120 --> 02:50:34,560 THEY LIVED IN THE PAST AND 3755 02:50:34,560 --> 02:50:35,960 INTEGRATE IT INTO THE ALL OF 3756 02:50:35,960 --> 02:50:36,800 US PROGRAM. 3757 02:50:36,800 --> 02:50:39,720 AND THEN LET'S WILL GO GET 3758 02:50:39,720 --> 02:50:41,320 THEIR ZIP CODES BY NUMBER OF 3759 02:50:41,320 --> 02:50:43,360 ZIP CODES AND WITH THIS 3760 02:50:43,360 --> 02:50:45,520 INFORMATION WE CAN BRING TO 3761 02:50:45,520 --> 02:50:47,960 BEAR SOME VERY POWERFUL DATA 3762 02:50:47,960 --> 02:50:49,880 SETS TO BEGIN TO UNDERSTAND 3763 02:50:49,880 --> 02:50:51,040 INDIVIDUAL EXPOSURE. 3764 02:50:51,040 --> 02:50:52,320 NOW PHASE 3 IS SOMETHING I 3765 02:50:52,320 --> 02:50:54,000 DON'T HAVE TIME TO TALK ABOUT 3766 02:50:54,000 --> 02:50:55,840 BUT THIS IS WHERE THE PROPOSAL 3767 02:50:55,840 --> 02:50:57,960 WOULD BE TO GO BEYOND GI S 3768 02:50:57,960 --> 02:51:00,720 DATA AND BEGIN TO LOOK AT THE 3769 02:51:00,720 --> 02:51:03,120 TOTALITY OF EXPOSURE USING 3770 02:51:03,120 --> 02:51:08,440 THINGS LIKE HIGH RESOLUTION 3771 02:51:08,440 --> 02:51:08,920 MASSSPECTOGRAPHY. 3772 02:51:08,920 --> 02:51:10,480 BUT ANY WAY TO EMPHASIZE HERE 3773 02:51:10,480 --> 02:51:12,280 ONCE YOU HAVE THE ADDRESS AND 3774 02:51:12,280 --> 02:51:14,000 ZIP CODE INFORMATION, YOU CAN 3775 02:51:14,000 --> 02:51:17,720 BRING IN VERY POWERFUL DATA 3776 02:51:17,720 --> 02:51:19,480 SETS AROUND AIR QUALITY 3777 02:51:19,480 --> 02:51:19,800 MODELS. 3778 02:51:19,800 --> 02:51:24,120 YOU CAN GET A PRETTY GOOD SET 3779 02:51:24,120 --> 02:51:26,200 OF DATA ON WHAT PEOPLE'S 3780 02:51:26,200 --> 02:51:27,720 EXPOSURE IS BASED ON WHERE 3781 02:51:27,720 --> 02:51:29,240 THEY LIVE AND WORK. 3782 02:51:29,240 --> 02:51:32,760 THERE ARE ALSO DAILY DATABASES 3783 02:51:32,760 --> 02:51:35,720 YOU CAN PASS INTO AS WELL AS 3784 02:51:35,720 --> 02:51:37,360 THE CDC SOCIAL VULNERABILITY 3785 02:51:37,360 --> 02:51:37,640 INDEX. 3786 02:51:37,640 --> 02:51:39,760 SO THE FIRST STEP IS TO WORK 3787 02:51:39,760 --> 02:51:41,520 WITH THIS DATA AND SEE IF WE 3788 02:51:41,520 --> 02:51:43,360 CAN TAKE IT TO PHASE 3 SO 3789 02:51:43,360 --> 02:51:44,880 AGAIN, WE ARE GOING TO MAKE 3790 02:51:44,880 --> 02:51:48,000 YOUR LIFE A LOT MORE 3791 02:51:48,000 --> 02:51:49,040 COMPLICATED -- MY GOAL. 3792 02:51:49,040 --> 02:51:50,600 SO LET'S GO ON WITH THE 3793 02:51:50,600 --> 02:51:53,200 REMAINING MINUTES I HAVE HERE, 3794 02:51:53,200 --> 02:51:54,280 THE ENVIRONMENTAL HEALTH 3795 02:51:54,280 --> 02:51:56,760 SCIENCES, WHY AM I HERE AND 3796 02:51:56,760 --> 02:51:58,160 WHY IS THERE THIS INTEREST IN 3797 02:51:58,160 --> 02:52:00,120 WHAT I AM DOING AND I WANT TO 3798 02:52:00,120 --> 02:52:02,200 STEAL ONE OF RICHARD'S SLIDES 3799 02:52:02,200 --> 02:52:05,000 THAT YOU SHOWED WHEN HE WAS AT 3800 02:52:05,000 --> 02:52:05,800 NIEHS LAST FEBRUARY. 3801 02:52:05,800 --> 02:52:09,120 AND I THINK WHAT IS BECOMING 3802 02:52:09,120 --> 02:52:11,840 INCREASINGLY CLEAR IS GENETICS 3803 02:52:11,840 --> 02:52:13,960 IS VERY IMPORTANT SINCE 3804 02:52:13,960 --> 02:52:16,280 GENETICS IS MY TRAINING BUT 3805 02:52:16,280 --> 02:52:18,680 THERE ARE ENVIRONMENTAL 3806 02:52:18,680 --> 02:52:20,280 EXPOSURES, AIR POLLUTION, 3807 02:52:20,280 --> 02:52:22,320 HEAVY METALS THAT CLEARLY ARE 3808 02:52:22,320 --> 02:52:24,280 ASSOCIATED WITH THE 3809 02:52:24,280 --> 02:52:26,560 DEVELOPMENT OF AD/ADRB AND 3810 02:52:26,560 --> 02:52:28,520 THIS IS TRUE PROBABLY FOR A 3811 02:52:28,520 --> 02:52:31,760 WHOLE VARIETY OF OTHER HEALTH 3812 02:52:31,760 --> 02:52:32,400 ISSUES AND DISEASES. 3813 02:52:32,400 --> 02:52:35,480 SO WE NEED TO INTEGRATE IN A 3814 02:52:35,480 --> 02:52:36,720 WAY WITH THE WORK THAT IS 3815 02:52:36,720 --> 02:52:39,440 BEING DONE AT THE NATIONAL 3816 02:52:39,440 --> 02:52:40,640 INCIDENT INSTITUTE OF AGING 3817 02:52:40,640 --> 02:52:41,320 AND OTHER PLACES. 3818 02:52:41,320 --> 02:52:43,800 BUT THIS IS ALSO GENERALLY 3819 02:52:43,800 --> 02:52:47,000 TRUE WHEN WE LOOK AT THE 3820 02:52:47,000 --> 02:52:52,600 HALLMARKS OF AGING, THERE IS 3821 02:52:52,600 --> 02:52:53,520 INSTABILITY, NUTRITION, 3822 02:52:53,520 --> 02:52:59,760 GENETIC ALTERATION, ALL KINDS 3823 02:52:59,760 --> 02:53:01,160 OF THINGS, MITOCHONDRIAL 3824 02:53:01,160 --> 02:53:02,760 EXPOSURES SO WE NOW ACCEPT 3825 02:53:02,760 --> 02:53:07,480 THAT THERE ARE A NUMBER OF 3826 02:53:07,480 --> 02:53:11,960 THINGS THAT IMPACT AGING 3827 02:53:11,960 --> 02:53:14,040 BIOLOGY. 3828 02:53:14,040 --> 02:53:19,320 SO LOOKING AT THE POTENTIAL 3829 02:53:19,320 --> 02:53:21,680 TELOMERE LINKED THERE ARE 3830 02:53:21,680 --> 02:53:25,520 MOLEC ULAR MARKERS OF STRESS 3831 02:53:25,520 --> 02:53:28,920 OR EXPOSURES AND RESILIENCE TO 3832 02:53:28,920 --> 02:53:29,560 UNDERSTANDING DISEASE RISK. 3833 02:53:29,560 --> 02:53:30,920 I UNDERSTAND THEY HAVE MADE A 3834 02:53:30,920 --> 02:53:32,960 LOT OF PROGRESS IN THE MEETING 3835 02:53:32,960 --> 02:53:34,880 HELD ABOUT A MONTH AGO AND 3836 02:53:34,880 --> 02:53:36,160 REALLY DEVELOPED STANDARD 3837 02:53:36,160 --> 02:53:38,360 OPERATING PROCEDURES SO WE CAN 3838 02:53:38,360 --> 02:53:48,440 BE MEASURING TE LOMERES AND 3839 02:53:48,440 --> 02:53:50,040 SHARE THIS ACROSS THE GLOBE. 3840 02:53:50,040 --> 02:53:52,560 BUT ALSO I THINK WE RECOGNIZE 3841 02:53:52,560 --> 02:53:56,480 OVER THE LIFESPAN THERE ARE 3842 02:53:56,480 --> 02:53:57,480 EPIGENETIC PROGRAMS THAT 3843 02:53:57,480 --> 02:54:01,720 DIRECT HOW OUR GENES ARE 3844 02:54:01,720 --> 02:54:03,200 ABOUTS DISRUPTED AND WHAT WE 3845 02:54:03,200 --> 02:54:05,480 HAVE COME TO RECOGNIZE IS 3846 02:54:05,480 --> 02:54:09,560 THERE ARE WINDOWS DURING THIS 3847 02:54:09,560 --> 02:54:14,400 LIFESPAN WHERE INDIVIDUALS ARE 3848 02:54:14,400 --> 02:54:19,160 SUSCEPTIBLE TO DEVELOPMENTAL 3849 02:54:19,160 --> 02:54:20,440 ORIGINS OF BIOEXPOSURE. 3850 02:54:20,440 --> 02:54:22,240 ONE OF THESE ITEMS WAS DONE IN 3851 02:54:22,240 --> 02:54:25,560 MY OWN LAB, A PESTICIDE NOW 3852 02:54:25,560 --> 02:54:29,360 OFF THE MARKET CALLED ROTENONE 3853 02:54:29,360 --> 02:54:33,440 AND WE KNOW A LOT ABOUT ITS 3854 02:54:33,440 --> 02:54:35,920 ACTIONS, IT SPECIFICALLY 3855 02:54:35,920 --> 02:54:39,240 TRANSPORTS THE TRANSCRIPTION 3856 02:54:39,240 --> 02:54:40,760 AND REDUCING MITOCHONDRIAL 3857 02:54:40,760 --> 02:54:42,000 FUNCTION. 3858 02:54:42,000 --> 02:54:45,960 SO WE DECIDE TO TREAT TEN 3859 02:54:45,960 --> 02:54:46,800 PARTS DURING PREGNANCY, AT 3860 02:54:46,800 --> 02:54:48,240 BIRTH WE STOP THE TREATMENT 3861 02:54:48,240 --> 02:54:54,120 AND LOOKED ACROSS THE ENTIRE 3862 02:54:54,120 --> 02:54:59,040 METHYLOME OF THE OFFSPRING OF 3863 02:54:59,040 --> 02:55:01,880 MOTHERS WITH ROTENONE AND WHAT 3864 02:55:01,880 --> 02:55:06,320 WE FOUND IS THESE WOULD BE 3865 02:55:06,320 --> 02:55:07,600 METHYLATION SITES ACROSS THE 3866 02:55:07,600 --> 02:55:09,520 GENOME, SEE IF I CAN ACTUALLY 3867 02:55:09,520 --> 02:55:11,440 DO THIS, AND THERE ARE SOME 3868 02:55:11,440 --> 02:55:17,880 SITES WHEN ARE METHYLATED AT 3869 02:55:17,880 --> 02:55:19,040 BIRTH, HYPER METHYLATED AND 3870 02:55:19,040 --> 02:55:21,360 WHAT WE FOUND IS THERE ARE TEN 3871 02:55:21,360 --> 02:55:26,240 PARTS TO A MILLION PARTS OF 3872 02:55:26,240 --> 02:55:27,440 ROTENONE DURING PREGNANCY AND 3873 02:55:27,440 --> 02:55:29,440 THOSE UP TO 18 MONTHS OF AGE 3874 02:55:29,440 --> 02:55:30,040 ARE AFFECTED. 3875 02:55:30,040 --> 02:55:31,640 SO LOTS OF THINGS COULD BE 3876 02:55:31,640 --> 02:55:34,480 HAPPENING SO THAT WINDOW OF 3877 02:55:34,480 --> 02:55:36,040 EXPOSURE DURING PREGNANCY IS 3878 02:55:36,040 --> 02:55:38,920 CRITICALLY IMPORTANT. 3879 02:55:38,920 --> 02:55:49,520 NOW ONE OF OUR COLLEAGUES DID 3880 02:55:51,760 --> 02:55:55,000 SOME STUDIES ON BPA SO IF YOU 3881 02:55:55,000 --> 02:55:56,880 ARE DRINKING YOUR SODA OUT OF 3882 02:55:56,880 --> 02:55:58,720 A CAN, YOU ARE EXPOSED TO 3883 02:55:58,720 --> 02:55:59,120 THIS. 3884 02:55:59,120 --> 02:56:02,240 OKAY, I SEE A FEW HANDS BUT 3885 02:56:02,240 --> 02:56:03,520 WE'LL TALK AFTERWARDS ABOUT 3886 02:56:03,520 --> 02:56:04,120 THIS. 3887 02:56:04,120 --> 02:56:05,840 MOST PEOPLE DON'T KNOW YOU ARE 3888 02:56:05,840 --> 02:56:07,920 BEING EXPOSED IN A LOOM UP IN 3889 02:56:07,920 --> 02:56:10,000 CAN BUT NOT THE PLASTIC 3890 02:56:10,000 --> 02:56:10,320 BOTTLE. 3891 02:56:10,320 --> 02:56:11,960 SO MOST PEOPLE KNOW ABOUT 3892 02:56:11,960 --> 02:56:12,280 THIS. 3893 02:56:12,280 --> 02:56:15,000 JUST A FEW DAYS, A RELATIVELY 3894 02:56:15,000 --> 02:56:17,200 LOW DOSE OF BPA AND THE BOTTOM 3895 02:56:17,200 --> 02:56:19,160 LINE HERE IS WHAT SHE 3896 02:56:19,160 --> 02:56:26,080 DETERMINED IS THE EXPOSURE IN 3897 02:56:26,080 --> 02:56:29,160 THE NEONATAL PERIOD IS 3898 02:56:29,160 --> 02:56:31,680 ACCELERATING AGING AND 3899 02:56:31,680 --> 02:56:32,760 METHYLATION AT A NUMBER OF 3900 02:56:32,760 --> 02:56:35,640 GENES SO THE NEWBORNS WERE 3901 02:56:35,640 --> 02:56:38,640 ACTUALLY LOOKING LIKE ADULTS 3902 02:56:38,640 --> 02:56:39,600 AT THEIR MOLECULAR LEVELS. 3903 02:56:39,600 --> 02:56:41,240 AND THE RESULTS OF THIS IS 3904 02:56:41,240 --> 02:56:43,880 MUCH LATER IN LIFE, INCREASING 3905 02:56:43,880 --> 02:56:46,840 THE IMPRESSION OF THIS GENE OF 3906 02:56:46,840 --> 02:56:49,840 EGR1 WHICH IS A MASTER 3907 02:56:49,840 --> 02:56:53,560 REGULATORY GENE FOR THE 3908 02:56:53,560 --> 02:56:55,120 METABOLOME AND WHAT IS 3909 02:56:55,120 --> 02:56:58,320 INTERESTING IS SHE FOUND SHE 3910 02:56:58,320 --> 02:57:00,040 CAN TRIGGER THE METABOLIC 3911 02:57:00,040 --> 02:57:02,400 SYNDROME IN ANIMALS SHE 3912 02:57:02,400 --> 02:57:06,600 TREATED WITH BPA WITH A 3913 02:57:06,600 --> 02:57:08,000 TYPICAL WESTERN MCDONALD'S 3914 02:57:08,000 --> 02:57:08,440 TYPE DIET. 3915 02:57:08,440 --> 02:57:10,640 NOW WITHOUT THE DIET, YOU ARE 3916 02:57:10,640 --> 02:57:11,120 FINE. 3917 02:57:11,120 --> 02:57:14,680 SO I WANT TO EXPRESS MY 3918 02:57:14,680 --> 02:57:16,120 APPRECIATION AT NIH FOR THE 3919 02:57:16,120 --> 02:57:17,880 COLLABORATIVE WORK WE HAVE 3920 02:57:17,880 --> 02:57:22,640 DONE TOGETHER AROUND THE 3921 02:57:22,640 --> 02:57:28,240 CONSORTIUM OF TARGET II AND 3922 02:57:28,240 --> 02:57:29,240 ENVIRONMENTAL EPIGENOMICS TO 3923 02:57:29,240 --> 02:57:31,960 FIND OUT WHAT ARE THOSE 3924 02:57:31,960 --> 02:57:35,240 CHANGES INDUCED BY 3925 02:57:35,240 --> 02:57:36,800 ENVIRONMENTAL EXPOSURES OVER 3926 02:57:36,800 --> 02:57:40,320 THE LIFESPAN AND CAN WE 3927 02:57:40,320 --> 02:57:41,040 MITIGATE THESE FACTORS. 3928 02:57:41,040 --> 02:57:43,440 SO THIS IS VERY IMPORTANT 3929 02:57:43,440 --> 02:57:45,840 RESEARCH AND I THINK I AM AT 3930 02:57:45,840 --> 02:57:47,560 20 MINUTES NOW AND I THINK WE 3931 02:57:47,560 --> 02:57:49,080 WANTED TO LEAVE TEN MINUTES 3932 02:57:49,080 --> 02:57:49,760 FOR Q&A. 3933 02:57:49,760 --> 02:57:53,080 SO LET ME JUST GO THROUGH 3934 02:57:53,080 --> 02:57:57,320 THESE HERE AND -- JUST GO 3935 02:57:57,320 --> 02:57:59,120 TO -- WOOPS, I NEED TO GO BACK 3936 02:57:59,120 --> 02:57:59,400 ONE. 3937 02:57:59,400 --> 02:58:05,920 SO AGAIN WE HAVE A STRANGE 3938 02:58:05,920 --> 02:58:09,480 PARTNERSHIP, BYING INTO THE 3939 02:58:09,480 --> 02:58:10,560 EXPOSURE USING EXPOSOME 3940 02:58:10,560 --> 02:58:12,840 FRAMEWORK, NOT JUST LOOKING AT 3941 02:58:12,840 --> 02:58:14,880 AIR POLLUTION WITH ALZHEIMER'S 3942 02:58:14,880 --> 02:58:17,360 BUT ALSO HEAVY METALS IN THE 3943 02:58:17,360 --> 02:58:19,000 FRAMEWORK AND ENHANCING OUR 3944 02:58:19,000 --> 02:58:21,400 ABILITIES TO LOOK AT THE 3945 02:58:21,400 --> 02:58:23,120 BIOMARKERS OF AGING TO MEASURE 3946 02:58:23,120 --> 02:58:26,080 THE IMPACT OF THE ENVIRONMENT 3947 02:58:26,080 --> 02:58:27,600 AND STUDYING THE GENE 3948 02:58:27,600 --> 02:58:28,640 ENVIRONMENT INTERACTIONS TO 3949 02:58:28,640 --> 02:58:29,400 UNDERSTAND THE INDIVIDUAL 3950 02:58:29,400 --> 02:58:34,160 RESPONSES TO THE ENVIRONMENTAL 3951 02:58:34,160 --> 02:58:34,560 EXPOSOME. 3952 02:58:34,560 --> 02:58:35,920 SO I WILL STOP AT THAT POINT, 3953 02:58:35,920 --> 02:58:37,200 THANK RICHARD AND ALL OF YOU 3954 02:58:37,200 --> 02:58:38,520 FOR THE OPPORTUNITY TO BE HERE 3955 02:58:38,520 --> 02:58:39,840 AND LOOK FORWARD TO ANY AND 3956 02:58:39,840 --> 02:58:49,280 ALL QUESTIONS YOU HAVE. 3957 02:58:49,280 --> 02:58:51,240 >>GREAT, THANK YOU SO MUCH, 3958 02:58:51,240 --> 02:58:52,040 Dr. WOYCHIK. 3959 02:58:52,040 --> 02:58:56,080 WE HAVE TIME FOR QUESTIONS. 3960 02:58:56,080 --> 02:58:57,880 >>SURE, THANK YOU. 3961 02:58:57,880 --> 02:58:59,400 THE GREAT JUST TO POSITION OF 3962 02:58:59,400 --> 02:59:02,280 THE TWO TALKS AND I AM JUST 3963 02:59:02,280 --> 02:59:03,280 WONDERING WHAT ARE YOUR 3964 02:59:03,280 --> 02:59:07,680 THOUGHTS MOVING FORWARD OF 3965 02:59:07,680 --> 02:59:08,760 COMBINING THESE, EXPOSOME 3966 02:59:08,760 --> 02:59:11,280 ISSUE AS IT GETS MORE THAT THE 3967 02:59:11,280 --> 02:59:12,880 CHEWER AND DEVELOPED AND THEN 3968 02:59:12,880 --> 02:59:14,280 THE OTHER APPROACH WE HEARD 3969 02:59:14,280 --> 02:59:16,600 ABOUT, IS IT TOO EARLY TO PUT 3970 02:59:16,600 --> 02:59:18,520 THESE TWO TOGETHER AND TOO 3971 02:59:18,520 --> 02:59:20,440 MASSIVE OR TO WE NEED TO 3972 02:59:20,440 --> 02:59:23,400 MATURE A HILL BILL, GET A 3973 02:59:23,400 --> 02:59:24,600 BETTER SENSE OF WHAT IS 3974 02:59:24,600 --> 02:59:27,040 IMPORTANT AND MERGE THEM IN 3975 02:59:27,040 --> 02:59:28,040 PARTICULAR STUDIES -- 3976 02:59:28,040 --> 02:59:30,200 >>GREAT QUESTION AND MY 3977 02:59:30,200 --> 02:59:34,640 SIMPLE ANSWER IS EXPOSOMICS 3978 02:59:34,640 --> 02:59:36,800 SHOULD BE ANOTHER TOOL TO 3979 02:59:36,800 --> 02:59:37,920 INTEGRATE INTO THE MODELING 3980 02:59:37,920 --> 02:59:38,200 TOOL. 3981 02:59:38,200 --> 02:59:41,280 SO WE CAN USE THE PRAGMATIC 3982 02:59:41,280 --> 02:59:42,960 EXPOSURE AND DO THINGS LIKE 3983 02:59:42,960 --> 02:59:44,000 HIGH RESOLUTION AT BEST. 3984 02:59:44,000 --> 02:59:45,880 IN FACT, IT IS PRETTY 3985 02:59:45,880 --> 02:59:47,600 REMARKABLE WITH THE THINGS YOU 3986 02:59:47,600 --> 02:59:52,600 CAN DECIPHER BY LOOKING AT A 3987 02:59:52,600 --> 02:59:53,480 MILLILITER OF BLOOD. 3988 02:59:53,480 --> 02:59:57,080 THERE ARE OVER 6 O 0 3989 02:59:57,080 --> 02:59:58,240 METABOLITES THAT ARE 3990 02:59:58,240 --> 03:00:01,320 INDICATORS OF EXPOSURE SO 3991 03:00:01,320 --> 03:00:04,280 ADDING THAT TO TRANS-OMICS AND 3992 03:00:04,280 --> 03:00:06,480 IN THE END IT WILL BE ALL OF 3993 03:00:06,480 --> 03:00:09,160 THESE STRATEGIES THAT MAKE A 3994 03:00:09,160 --> 03:00:09,560 TINS. 3995 03:00:09,560 --> 03:00:11,120 SO NIEHS, WE HOPE TO BE 3996 03:00:11,120 --> 03:00:12,160 LEADING THE STRATEGY TO 3997 03:00:12,160 --> 03:00:15,040 DEVELOP THE TYPES OF TOOLS TO 3998 03:00:15,040 --> 03:00:16,440 BE DISSEMINATED TO DENG AND 3999 03:00:16,440 --> 03:00:26,120 ALL OF YOU SO THAT THIS CAN BE 4000 03:00:26,120 --> 03:00:27,520 USED FOR STUDYING THAT GOING 4001 03:00:27,520 --> 03:00:28,040 FORWARD. 4002 03:00:28,040 --> 03:00:29,640 DID I ANSWER YOUR QUESTION? 4003 03:00:29,640 --> 03:00:30,920 >>YES, THINKING OF TOOLS OF 4004 03:00:30,920 --> 03:00:32,040 IMPORTANCE, I AM THINKING 4005 03:00:32,040 --> 03:00:34,600 ABOUT THE OM ICS STUDIES HAVE 4006 03:00:34,600 --> 03:00:39,240 THAT BEEN DONE TODAY, THE ROSS 4007 03:00:39,240 --> 03:00:41,720 STUDY, THERE HAVE BEEN STUDIES 4008 03:00:41,720 --> 03:00:43,840 DONE AND YOU CAN IMAGINE THOSE 4009 03:00:43,840 --> 03:00:45,480 STUDIES ALL OVER AGAIN, YOU 4010 03:00:45,480 --> 03:00:47,320 NEED TO BE EXAMINING 4011 03:00:47,320 --> 03:00:49,000 EVERYTHING THE SUBJECT IS 4012 03:00:49,000 --> 03:00:54,880 EXPOSED TO AND SEEMS LIKE A 4013 03:00:54,880 --> 03:00:56,040 PRACTICAL CHALLENGE WHERE YOU 4014 03:00:56,040 --> 03:00:58,360 DON'T HAVE TO START OVER AGAIN 4015 03:00:58,360 --> 03:01:00,600 BUT THE NEXT TIME YOU LOOK AT 4016 03:01:00,600 --> 03:01:09,480 THEM IN A GROUP YOU HAVE THE 4017 03:01:09,480 --> 03:01:12,040 EXPOSOME-OM ICS WHERE YOU 4018 03:01:12,040 --> 03:01:13,400 DETERMINE THE EXPOSURES. 4019 03:01:13,400 --> 03:01:13,840 >>THANK YOU. 4020 03:01:13,840 --> 03:01:18,320 A LOT OF OMICS BUT NOT 4021 03:01:18,320 --> 03:01:19,720 PROTEOMICS BECAUSE THAT IS 4022 03:01:19,720 --> 03:01:22,600 MORE LIMITED AND CHALLENGING. 4023 03:01:22,600 --> 03:01:23,880 THE GENERAL QUESTION, YOU KNOW 4024 03:01:23,880 --> 03:01:26,320 IS HOW DO WE INTEGRATE ACROSS 4025 03:01:26,320 --> 03:01:29,480 ALL THESE DATA SETS AND CROSS 4026 03:01:29,480 --> 03:01:31,440 LABORATORIES AND INVESTIGATORS 4027 03:01:31,440 --> 03:01:32,600 TO COORDINATE WHAT WHAT IS 4028 03:01:32,600 --> 03:01:35,080 BEING DONE TO BE THE MOST 4029 03:01:35,080 --> 03:01:35,520 COMPREHENSIVE. 4030 03:01:35,520 --> 03:01:36,760 >>I THINK IT IS A GREAT 4031 03:01:36,760 --> 03:01:39,520 QUESTION AND PART OF IT IS 4032 03:01:39,520 --> 03:01:41,120 JUST BRINGING AWARENESS OF THE 4033 03:01:41,120 --> 03:01:44,080 IMPORTANCE OF THE ENVIRONMENT. 4034 03:01:44,080 --> 03:01:45,320 REMARKABLY ENOUGH, AND I THINK 4035 03:01:45,320 --> 03:01:47,320 THIS GROUP IS PRETTY WELL 4036 03:01:47,320 --> 03:01:49,600 INFORMED, BUT THERE ARE A LOT 4037 03:01:49,600 --> 03:01:51,120 OF GENETICS AND GENOMICS 4038 03:01:51,120 --> 03:01:52,840 GROUPS OUT THERE COLLECTING 4039 03:01:52,840 --> 03:01:54,920 BLOOD PRESSURE AND BMI AND 4040 03:01:54,920 --> 03:01:58,600 OTHER THINGS THAT -- IN FACT 4041 03:01:58,600 --> 03:02:01,280 AT THAT MEETING, THAT KICKOFF 4042 03:02:01,280 --> 03:02:04,160 MEETING AND FRANCIS AND ERIC 4043 03:02:04,160 --> 03:02:05,760 LAUNCHED, I RAISED MY HAND AND 4044 03:02:05,760 --> 03:02:06,800 I SAID WHERE IS THE 4045 03:02:06,800 --> 03:02:07,840 ENVIRONMENT IN HERE AND HE 4046 03:02:07,840 --> 03:02:09,680 SAID WELL HOW DO YOU STUDY THE 4047 03:02:09,680 --> 03:02:10,080 ENVIRONMENT. 4048 03:02:10,080 --> 03:02:11,440 THAT WAS HIS RESPONSE. 4049 03:02:11,440 --> 03:02:13,280 AND SO THAT IS PART OF WHAT WE 4050 03:02:13,280 --> 03:02:15,160 NEED TO DO, INCREASE THE 4051 03:02:15,160 --> 03:02:18,120 AWARENESS THAT THERE ARE 4052 03:02:18,120 --> 03:02:18,720 ENVIRONMENTAL TOOLS THAT 4053 03:02:18,720 --> 03:02:19,680 CONTRIBUTE TO THE DATA AND 4054 03:02:19,680 --> 03:02:21,880 THEN PART OF WHAT WE NEED TO 4055 03:02:21,880 --> 03:02:24,920 BE DOING IS PACKAGING UP 4056 03:02:24,920 --> 03:02:26,920 EXPOSOMICS IN A SEAMLESS WAY 4057 03:02:26,920 --> 03:02:28,400 TO BE INTEGRATED SO YOU KNOW 4058 03:02:28,400 --> 03:02:30,360 EXACTLY HOW TO USE THIS DATA 4059 03:02:30,360 --> 03:02:35,360 TO INTEGRATE IT WITH 4060 03:02:35,360 --> 03:02:35,880 TRANSCRIPTOMICS AND 4061 03:02:35,880 --> 03:02:38,600 METHYLATION AND OTHER THINGS. 4062 03:02:38,600 --> 03:02:40,440 DOES THAT ANSWER YOUR 4063 03:02:40,440 --> 03:02:40,800 QUESTION? 4064 03:02:40,800 --> 03:02:41,920 >> WE LOOK FORWARD TO WORKING 4065 03:02:41,920 --> 03:02:44,640 WITH YOU IN DEVELOPING THAT 4066 03:02:44,640 --> 03:02:45,480 INFORMATION. 4067 03:02:45,480 --> 03:02:47,120 >>AND APPLYING WHAT WE HAVE 4068 03:02:47,120 --> 03:02:48,600 DEVELOPED TOGETHER TO SOME 4069 03:02:48,600 --> 03:02:50,840 VERY IMPORTANT DISEASE AREAS 4070 03:02:50,840 --> 03:02:52,000 LIKE ALZHEIMER'S DISEASE. 4071 03:02:52,000 --> 03:02:54,000 AND EXACT SHE WHAT ARE THE 4072 03:02:54,000 --> 03:02:57,720 ROLES OF NOT JUST CADMIUM OR 4073 03:02:57,720 --> 03:02:59,520 LEAD OR AIR POLLUTION BUT 4074 03:02:59,520 --> 03:03:00,600 REALLY LOOKING ACROSS THESE 4075 03:03:00,600 --> 03:03:01,760 DIFFERENT SOURCES AND THEN 4076 03:03:01,760 --> 03:03:06,320 LOOKING AT POTENTIAL THE 4077 03:03:06,320 --> 03:03:07,640 EPIGENETIC SIGNATURES THAT 4078 03:03:07,640 --> 03:03:10,000 ARISE FROM THESE MULTIPLE 4079 03:03:10,000 --> 03:03:10,440 EXPOSURES. 4080 03:03:10,440 --> 03:03:11,720 BECAUSE IT MAY BE THAT IN THE 4081 03:03:11,720 --> 03:03:15,040 END THERE IS A EPIGENETIC 4082 03:03:15,040 --> 03:03:16,880 SIGNATURE OF EXPOSURES THAT 4083 03:03:16,880 --> 03:03:17,960 COULD BE BEST USED. 4084 03:03:17,960 --> 03:03:21,640 WE ALREADY HAVE THE 4085 03:03:21,640 --> 03:03:24,040 METHYLATION INTEGRATED IN YOUR 4086 03:03:24,040 --> 03:03:24,360 ANALYSIS 4087 03:03:24,360 --> 03:03:27,320 >> DOWNSTREAM THE APPLICATION 4088 03:03:27,320 --> 03:03:29,520 AND PRACTICE CATS, JUST AS AN 4089 03:03:29,520 --> 03:03:31,360 EXAMPLE, WHEN DO YOU TELL 4090 03:03:31,360 --> 03:03:33,960 PEOPLE TO TURN IN YOUR 4091 03:03:33,960 --> 03:03:35,320 ALUMINUM CANS BECAUSE YOU 4092 03:03:35,320 --> 03:03:36,760 DIDN'T KNOW IT WAS THE 4093 03:03:36,760 --> 03:03:39,920 ALUMINUM CANS AND NOT THE 4094 03:03:39,920 --> 03:03:41,520 PLASTIC BOTTLES THAT MIGHT BE 4095 03:03:41,520 --> 03:03:45,640 THE SOURCE OF TOXINS. 4096 03:03:45,640 --> 03:03:48,320 -- PRACTICE CATS. 4097 03:03:48,320 --> 03:03:52,840 >>WELL, THAT IS COMPLICATED. 4098 03:03:52,840 --> 03:03:54,600 THE PFAS, ALL THESE WONDERFUL 4099 03:03:54,600 --> 03:03:58,000 THINGS THAT MAKE YOUR CLOTHING 4100 03:03:58,000 --> 03:03:59,840 RESISTANT TO WATER, I MEAN 4101 03:03:59,840 --> 03:04:01,000 THEY ARE POTENTIALLY DANGEROUS 4102 03:04:01,000 --> 03:04:03,280 AND WE JUST HAVE TO BE CAREFUL 4103 03:04:03,280 --> 03:04:03,640 WITH THAT. 4104 03:04:03,640 --> 03:04:05,920 SO IF YOU WANT TO AVOID THE 4105 03:04:05,920 --> 03:04:06,960 EXPOSURE, WHAT ARE THE THINGS 4106 03:04:06,960 --> 03:04:09,120 YOU SHOULD STAY AWAY FROM AND 4107 03:04:09,120 --> 03:04:11,520 MOST PEOPLE DON'T KNOW THAT 4108 03:04:11,520 --> 03:04:13,160 HIGH-TECH DENTAL FLOSS IS 4109 03:04:13,160 --> 03:04:15,080 ACTUALLY COATED WITH PFAS AND 4110 03:04:15,080 --> 03:04:16,600 IF YOU HOOK AT THE AGREED 4111 03:04:16,600 --> 03:04:19,600 KWREPTS OF THESE 4112 03:04:19,600 --> 03:04:21,560 PFAS-CONTAINING OR ACTUALLY 4113 03:04:21,560 --> 03:04:23,320 THERE WAS AN ARTICLE SOME 4114 03:04:23,320 --> 03:04:26,040 PLACE, MAYBE CONSUMER REPORTS, 4115 03:04:26,040 --> 03:04:27,680 BUT THE DIFFERENT NONSTICK 4116 03:04:27,680 --> 03:04:32,800 PANS AND SO THEY ALL CLAIM 4117 03:04:32,800 --> 03:04:34,280 THEY ARE PFFOA FREE. 4118 03:04:34,280 --> 03:04:38,520 THAT IS THE ORIGINAL AKOCH BON 4119 03:04:38,520 --> 03:04:40,560 TO TEFLON BUT THEY ARE 4120 03:04:40,560 --> 03:04:44,880 PROBABLY USING THREE CARBONS 4121 03:04:44,880 --> 03:04:47,880 OF PFAS TO REPLACE PFOA SO 4122 03:04:47,880 --> 03:04:50,560 THAT IS SOMETHING THAT FALLS 4123 03:04:50,560 --> 03:04:52,280 SQUARELY IN OUR DOMAIN AND WE 4124 03:04:52,280 --> 03:04:54,240 NEED TO BETTER UNDERSTAND 4125 03:04:54,240 --> 03:04:54,560 THAT. 4126 03:04:54,560 --> 03:04:57,040 AND IT IS THE ALUMINUM CANS 4127 03:04:57,040 --> 03:04:59,360 THAT ARE COATED WITH PLASTICS 4128 03:04:59,360 --> 03:05:03,400 THAT KEEP THE COKE FROM 4129 03:05:03,400 --> 03:05:05,560 ERODING THE CAN AND THUS THE 4130 03:05:05,560 --> 03:05:06,160 BFA. 4131 03:05:06,160 --> 03:05:07,480 SO A COMPLICATED QUESTION 4132 03:05:07,480 --> 03:05:09,440 THERE, RICHARD, BUT THE OTHER 4133 03:05:09,440 --> 03:05:13,720 THING TOO IS IT LOOKING AT THE 4134 03:05:13,720 --> 03:05:14,600 MOLECULAR SIGNIFICANTURES OF 4135 03:05:14,600 --> 03:05:16,360 EXPOSURE SO WE HAVE TO BE 4136 03:05:16,360 --> 03:05:18,240 LOOKING AT EVERY SINGLE 4137 03:05:18,240 --> 03:05:19,520 POSSIBLE THING WE'RE EXPOSED 4138 03:05:19,520 --> 03:05:22,280 TO THAT WE KNOW AND DON'T KNOW 4139 03:05:22,280 --> 03:05:25,680 OR DO WE LOOK AT THE 4140 03:05:25,680 --> 03:05:27,880 EPIGENETIC SIGNATURE AFTER A 4141 03:05:27,880 --> 03:05:29,440 COMPLEX EXPOSURE AND THAT 4142 03:05:29,440 --> 03:05:30,640 MIGHT BE SOME PREDICTION BASED 4143 03:05:30,640 --> 03:05:32,240 ON MIGHT HAVE OWN WORK OF AN 4144 03:05:32,240 --> 03:05:33,680 AREA THAT I THINK IS AN AREA 4145 03:05:33,680 --> 03:05:38,480 WE NEED TO BE EXPLORING MORE. 4146 03:05:38,480 --> 03:05:39,760 ANOTHER QUESTION. 4147 03:05:39,760 --> 03:05:40,880 >>YES, MAYBE VERY QUICK. 4148 03:05:40,880 --> 03:05:42,240 SO I FOUND IT REALLY 4149 03:05:42,240 --> 03:05:43,400 INTERESTING THAT YOU ARE GOING 4150 03:05:43,400 --> 03:05:46,720 TO BE WORKING ON YOUR 4151 03:05:46,720 --> 03:05:48,880 FRAMEWORK FOR EXPOSURE BECAUSE 4152 03:05:48,880 --> 03:05:52,760 YOU JUST MENTIONED, AND WE ALL 4153 03:05:52,760 --> 03:05:54,000 GROWNED, AND THINKING ABOUT 4154 03:05:54,000 --> 03:05:56,160 OUR OWN EXPOSURE FOR THE 4155 03:05:56,160 --> 03:06:00,000 VARIOUS PRODUCTS, FOR ME AS A 4156 03:06:00,000 --> 03:06:02,200 HEALTH DISPARITY RESEARCHER, 4157 03:06:02,200 --> 03:06:06,240 THE ROOT FUNDAMENTAL ROOT OF 4158 03:06:06,240 --> 03:06:09,600 ANY FRAMEWORK FOR HEALTH IS 4159 03:06:09,600 --> 03:06:10,320 THEISMS. 4160 03:06:10,320 --> 03:06:12,280 SO RACISM, SEXISM AND 4161 03:06:12,280 --> 03:06:12,680 CAPITALISM. 4162 03:06:12,680 --> 03:06:14,880 YOU KNOW PEOPLE ARE SELLING 4163 03:06:14,880 --> 03:06:16,920 US -- COMPANIES ARE SELLING US 4164 03:06:16,920 --> 03:06:19,120 THESE PRODUCTS THAT ARE 4165 03:06:19,120 --> 03:06:20,320 POISONOUS AND THESE ARE FORCES 4166 03:06:20,320 --> 03:06:22,280 THAT ARE SORT OF PATTERNING 4167 03:06:22,280 --> 03:06:26,560 OUR EXPOSURE TO SOME OF THESE 4168 03:06:26,560 --> 03:06:28,040 THINGS BUT ANOTHER QUESTION I 4169 03:06:28,040 --> 03:06:31,400 WANTED TO ASK YOU IS YOU 4170 03:06:31,400 --> 03:06:33,400 MENTIONED THE GEOCODING IN ALL 4171 03:06:33,400 --> 03:06:36,720 OF US AND BECAUSE WE'RE AGING 4172 03:06:36,720 --> 03:06:38,720 RESEARCHERS, WE REALLY DO 4173 03:06:38,720 --> 03:06:39,840 THINK ABOUT THE ENTIRE LIFE 4174 03:06:39,840 --> 03:06:40,200 COURSE. 4175 03:06:40,200 --> 03:06:44,560 SO I WANTED TO ASK YOU HOW 4176 03:06:44,560 --> 03:06:48,400 THOSE GEOCODED EXPOSURES ARE 4177 03:06:48,400 --> 03:06:49,680 AVAILABLE IN PRIOR YEARS. 4178 03:06:49,680 --> 03:06:51,720 YOU KNOW GIVEN SOME OF THE 4179 03:06:51,720 --> 03:06:53,320 OMICS YOU ARE GOING TO RUN, I 4180 03:06:53,320 --> 03:06:56,480 DON'T KNOW IF THEY ARE ALL 4181 03:06:56,480 --> 03:07:02,960 LAST 30 DAYS' EXPOSURE BUT THE 4182 03:07:02,960 --> 03:07:03,680 EPIGENETICS EXPOSURE CERTAINLY 4183 03:07:03,680 --> 03:07:07,000 ARE NOT SO HOW WILL THOSE 4184 03:07:07,000 --> 03:07:09,600 GEOCODED EXPOSURES RELATE TO 4185 03:07:09,600 --> 03:07:11,080 EARLY CHILDHOOD EXPOSURES FOR 4186 03:07:11,080 --> 03:07:13,280 PEOPLE WHO ARE NOW OLDER? 4187 03:07:13,280 --> 03:07:20,720 >>WELL, THAT IS A GREAT 4188 03:07:20,720 --> 03:07:21,960 QUESTION. 4189 03:07:21,960 --> 03:07:24,320 I WILL ASK Dr. DENG ABOUT 4190 03:07:24,320 --> 03:07:27,720 THAT BUT I THINK IT IS THE 4191 03:07:27,720 --> 03:07:29,600 LONGITUDINAL STUDY, LOOKING AT 4192 03:07:29,600 --> 03:07:32,160 A SNAPSHOT IS NOT PARTICULARLY 4193 03:07:32,160 --> 03:07:33,680 USEFUL BUT LOOKING OVER TIME. 4194 03:07:33,680 --> 03:07:36,800 WHAT WAS MY MOTHER EXPOSED TO 4195 03:07:36,800 --> 03:07:38,000 IN THE 1950S? 4196 03:07:38,000 --> 03:07:40,120 A WHOLE BUNCH OF STUFF THAT IS 4197 03:07:40,120 --> 03:07:42,640 LIKELY TO BE AFFECTING MY MEN 4198 03:07:42,640 --> 03:07:44,440 TAB LIMB AS AN ADULT SO THAT 4199 03:07:44,440 --> 03:07:46,560 IS WHERE I AM THINKING WE NEED 4200 03:07:46,560 --> 03:07:48,680 TO BE WORKING ON THE 4201 03:07:48,680 --> 03:07:50,560 ESPECIALLY ME GENETIC 4202 03:07:50,560 --> 03:07:50,920 EXPOSURES. 4203 03:07:50,920 --> 03:07:53,280 THINGS I SHOWED FROM MY OWN 4204 03:07:53,280 --> 03:07:53,560 LAB. 4205 03:07:53,560 --> 03:07:56,600 THE CHANGES THAT HAPPEN AS A 4206 03:07:56,600 --> 03:07:58,920 CONSEQUENCE OF APPROACH SURE 4207 03:07:58,920 --> 03:08:02,480 DURING PREGNANCY CONTINUE 4208 03:08:02,480 --> 03:08:03,960 AFFECTING YOUR METHYLONE MUCH 4209 03:08:03,960 --> 03:08:05,720 LATER IN LIFE AND ALSO 4210 03:08:05,720 --> 03:08:07,880 DEVELOPING A MORE ROBUST SET 4211 03:08:07,880 --> 03:08:08,480 OF BIOMARKERS. 4212 03:08:08,480 --> 03:08:11,280 WHAT ARE THE THINGS IN ACAN I 4213 03:08:11,280 --> 03:08:16,680 GO DIGS TO ESPECIALLY -- 4214 03:08:16,680 --> 03:08:21,240 THINGS IN ADDITION TO 4215 03:08:21,240 --> 03:08:23,160 EPIGENETIC EXPOSURES TO GET 4216 03:08:23,160 --> 03:08:24,480 THAT WINDOW TO ADJUST FOR. 4217 03:08:24,480 --> 03:08:26,200 PUT THE OTHER THING I WANT TO 4218 03:08:26,200 --> 03:08:27,920 POINT OUT HERE IS THE 4219 03:08:27,920 --> 03:08:31,080 CHEMICALS ARE NOT JUST 4220 03:08:31,080 --> 03:08:34,160 RELATING TO ROTONOME OR BPA 4221 03:08:34,160 --> 03:08:39,400 BUT THINGS THAT AFFECT 4222 03:08:39,400 --> 03:08:40,640 ENVIRONMENTA ALMOST JUSTICE. 4223 03:08:40,640 --> 03:08:44,120 PSYCHO AND SOCIAL STRESS HAVE 4224 03:08:44,120 --> 03:08:48,640 A GREAT AFFECT ON WHETHER WE 4225 03:08:48,640 --> 03:08:51,360 ADJUST TO EXPOSURE. 4226 03:08:51,360 --> 03:08:56,560 FISH WITH FATTY ACIDS AND 4227 03:08:56,560 --> 03:09:00,080 EXPOSED TO AMERICA ROUX IMPACT 4228 03:09:00,080 --> 03:09:05,120 CARDIO HEALTH AND BLUEBERRIES 4229 03:09:05,120 --> 03:09:08,720 AND BLACKBERRIES CONTAIN THESE 4230 03:09:08,720 --> 03:09:10,560 POLYPHENOLS THAT MAY BE 4231 03:09:10,560 --> 03:09:10,960 BENEFICIAL. 4232 03:09:10,960 --> 03:09:14,840 SO GETTING TO THE BENEFICIAL 4233 03:09:14,840 --> 03:09:16,200 HEALTH OF NONCHEMICAL 4234 03:09:16,200 --> 03:09:18,840 EXPOSURES HAVE TO BE PART OF 4235 03:09:18,840 --> 03:09:21,160 THE EQUATION PUT ALSO I COULD 4236 03:09:21,160 --> 03:09:24,120 GIVE A WHOLE LECTURE ON 4237 03:09:24,120 --> 03:09:24,960 ENVIRONMENTAL JUSTICE, THOSE 4238 03:09:24,960 --> 03:09:26,320 COMMUNITIES OUT THERE WITH 4239 03:09:26,320 --> 03:09:27,280 HEALTH DISPARITIES AND THOSE 4240 03:09:27,280 --> 03:09:28,280 ARE THE COMMUNITIES WHERE 4241 03:09:28,280 --> 03:09:29,920 PEOPLE ARE LIVING IN HOMES 4242 03:09:29,920 --> 03:09:31,880 WITH LEAD PAINT, THOSE ARE THE 4243 03:09:31,880 --> 03:09:35,120 COMMUNITIES THAT ARE LOCATED 4244 03:09:35,120 --> 03:09:38,000 JUST DOWNSTREAM FROM LEAD 4245 03:09:38,000 --> 03:09:39,080 SMELTER, COMMUNITIES THAT ARE 4246 03:09:39,080 --> 03:09:41,960 I ADJACENT TO THE POWER 4247 03:09:41,960 --> 03:09:43,760 PRODUCTION PLANTS SO THERE ARE 4248 03:09:43,760 --> 03:09:44,440 ENVIRONMENTAL EXPOSURES THAT 4249 03:09:44,440 --> 03:09:46,640 WE NEED TO PAY ATTENTION TO. 4250 03:09:46,640 --> 03:09:55,280 DOES THAT ANSWER YOUR 4251 03:09:55,280 --> 03:09:56,600 QUESTION? 4252 03:09:56,600 --> 03:09:59,240 [LAUGHTER] 4253 03:09:59,240 --> 03:10:01,800 AND ALL ENCOMPASSING QUESTION 4254 03:10:01,800 --> 03:10:05,080 WITH BPA AND PLASTIC BOTTLES. 4255 03:10:05,080 --> 03:10:05,760 ANYTHING ELSE? 4256 03:10:05,760 --> 03:10:09,040 >>WE WILL MAKE THIS A REGULAR 4257 03:10:09,040 --> 03:10:09,920 UPDATE. 4258 03:10:09,920 --> 03:10:10,400 [LAUGHTER] 4259 03:10:10,400 --> 03:10:11,920 >>YEAH, SO YOU KNOW WHAT THAT 4260 03:10:11,920 --> 03:10:13,400 MEANS, RICHARD, IT MEANS YOU 4261 03:10:13,400 --> 03:10:15,800 WILL BE COMING DOWN TO NORTH 4262 03:10:15,800 --> 03:10:18,680 CAROLINA WITH SOME REGULARITY. 4263 03:10:18,680 --> 03:10:19,160 >>FAIR ENOUGH. 4264 03:10:19,160 --> 03:10:20,680 THERE IS A CONNECTION THERE. 4265 03:10:20,680 --> 03:10:24,960 >>THANKS AGAIN FOR YOUR 4266 03:10:24,960 --> 03:10:25,600 ATTENTION. 4267 03:10:25,600 --> 03:10:27,840 >>ALL RIGHT, WELL, THAT 4268 03:10:27,840 --> 03:10:29,440 CONCLUDES THEN OUR MAY COUNCIL 4269 03:10:29,440 --> 03:10:30,040 MEETING. 4270 03:10:30,040 --> 03:10:33,320 I WANT TO AGAIN THANK ALL OUR 4271 03:10:33,320 --> 03:10:34,840 COUNCIL MEMBERS FOR ALL THEIR 4272 03:10:34,840 --> 03:10:36,000 HARD WORK AND RICH DISCUSSION 4273 03:10:36,000 --> 03:10:37,840 WE HAD IN THESE PAST FEW DAYS 4274 03:10:37,840 --> 03:10:42,400 AND AGAIN, IT WAS A PLEASURE 4275 03:10:42,400 --> 03:10:43,320 SEEING -- LITLY SEEING YOU 4276 03:10:43,320 --> 03:10:45,880 DURING THIS TIME TOO. 4277 03:10:45,880 --> 03:10:50,080 RICHARD, FINAL WORDS? 4278 03:10:50,080 --> 03:10:51,120 >>USE THE GAVEL. 4279 03:10:51,120 --> 03:10:52,000 >>BUSINESS ADJOURNED, YES. 4280 03:10:52,000 --> 00:00:00,000 [LAUGHTER]