I'D LIKE TO WELCOME EVERYONE TO
THE 146 MEETING OF THE NATIONAL
INSTITUTE ON AGING NATIONAL
ADVISORY COUNCIL ON AGING.
MY NAME IS KEN SANTORA AND
BEFORE WE GET STARTED, AND I
TURN IT OVER TO OUR DIRECTOR
Dr. RICHARD HODES, WE'LL HAVE
A ROUND OF INTRODUCTIONS OF OUR
COUNCIL MEMBERS.
WHEN I SAY IF CAN YOU INTRODUCE
YOURSELVES AND WE'LL START WITH
Dr. BAKER.
>> JUMPING RIGHT IN.
OK, HI MY NAME IS AARON BAKER
FROM THE MAYO CLINIC AND I'M AN
ASSOCIATE PROFESSOR FOCUSING IN
THE BASIC SCIENCE ANGLE AND I
WORK WITH A LOT OF MOUSE MODELS,
NOVEL, DISEASE AND SO FOURTH AND.
>> I'M PROFESSOR OF MEDICINE AT
HOWARD MEDICINE SCHOOL AND THE
PEP CENTER.
I HAVE WIDE INTEREST IN TO
PREVENT AND TREAT AGE-RELATED
CONDITIONS.
>> ANNE, ARE YOU ON YET?
>> WE'LL COME BACK.
Dr. CRUZ.
Dr. DRISCOLL.
>> GOOD MORNING, MY NAME IS
MONICA DRISCOLL AND I'M A
DISTINGUISHED PROFESSOR.
I AM INVERT BRETT NEURO
GENETICIST WITH A STRONG
INTEREST IN AGEING AND NEURO
DEGENERATION.
>> THANK YOU.
Dr. FULLMER.
>> I'M THE PRESIDENT OF THE JOHN
A. HEART FOUNDATION IN NEW YORK
CITY AND PROFESSOR AT THE MOUNT
SINAI SCHOOL OF NURSING AND MY
AREA RESEARCH IS ELDER ABUSE AND
NEGLECT AND VERY HAPPY TO BE ON
THE COMMITTEE.
THANK YOU.
>> Dr. GREENSPAN.
>> HI, MY NAME IS SUSAN
GREENSPAN I'M PROFESSOR OF
MEDICINE AT THE UNIVERSITY OF
PITTSBURGH.
I'M A DIRECTOR OF OUR PEPPER
CENTER AND T32 AND I'M AEN
DEGREE CRON YOA -- INAGE RELATED PROBLEMS AND I'M
HAPPY TO BE PART OF THE
COMMITTEE.
THANK YOU.
>> THANK YOU.
WELCOME.
Dr. WONG.
>> HI, GOOD MORNING.
I'M (INAUDIBLE) AND SENIOR
INVESTIGATOR AND PROFESSOR OF
NEUROLOGY AT USF.
RESEARCH FOCUS IS ON ALZHEIMER'S
DISEASE, ESPECIALLY INTEREST ON
EPOE4.
THANK YOU.
>> I'M CYNTHIA A RETIRED PASTOR
LIVING IN UPSTATE NEW YORK AND
I'VE ALSO BEEN A RESEARCH
PARTICIPANT IN THE STUDY FOR 12
PLUS YEARS LIVING WITH EARLY
STAGE ALZHEIMER'S DISEASE.
RESEARCH HAS BEEN MY PASSION.
>> THANK YOU.
>> WE'LL GO BIANCA ANDREESCU
BACK TO DrSAM CASE.>> I'M AN ECONOMIST AT PRINCE.
>> Tom: TON UNIVERSITY AND MY
RESEARCH IS PRIMARILY ON THE
JOINT EVOLUTION OF ECONOMIC
STATUS AND HEALTH STATE US OVER
THE LIFE SOURCE AND ESPECIALLY
NOW WITH THE IMPORTANCE OF EARLY
AND MID LIFE HEALTH ON
LATER-LIFE HEALTH.
>> THANK YOU, AND WELCOME Dr.
CASE.
I'LL GO BACK ALSO TO Dr. CRUZ.
>> HI, CAN YOU HEAR ME?
>> YES.
>> I GUESS WE'RE DOING
INTRODUCTIONS RIGHT.
GOOD MORNING, EVERYONE.
SO, I HAVE THE PLEASURE TO LEAD
THE NATIONAL HISPANIC COUNCIL ON
AGING AND THE MISSION OF THE
ORGANIZATION IS TO IMPROVE THE
LIVES OF HISPANIC OLDER ADULTS
AND THEIR CAREGIVERS.
SO, THROUGH THAT WORK, HEALTH IS
ONE OF OUR MAIN PILLARS AND
DOING HEALTH EQUITY RESEARCH,
PARTICULARLY AROUND AREAS THAT
IMPACT, THAT THIS
PROPORTIONATELY IMPACT HISPANIC,
OLDER ADULTS, IS ONE OF OUR
PRIORITIES SO RIGHT NOW, WE'RE
DOING SOME RESEARCH, QUALITATIVE
RESEARCH AROUND ASTHMA AND WE
HAVE ALSO BEEN WORKING ON
OBESITY SO TRYING TO UNDERSTAND
SOME OF THE CHALLENGES AND
BARRIERS AROUND OBESITY AND
LOSING WEIGHT AMONG HISPANIC,
OLDER ADULTS, PARTICULARLY AS IT
RELATES TO CHRONIC ILLNESSES.
SO IT'S A GREAT PLEASURE TO BE
HERE.
>> THANK YOU, WELCOME TO OUR
COUNCIL.
Dr. LONGO.
>> THANK YOU.
HI, I'M FRANK AND I'M A
NEUROLOGIST AND I SHARE THE
DEPARTMENT OF NEUROLOGY HERE AT
STANFORD.
I DO RESEARCH ON HALLUCINATING
MECHANISMS OF NEURODEGENERATIVE
DISEASE SUCH AS ALZHEIMER'S AND
DEVELOPMENT OF SMALL MOLECULE
THERAPEUTICS FROM MOUSE MODELS
TO HUMAN TRIALS AND IT'S GREAT
TO BE ON.
>> THANK YOU, WELCOME Dr.
LONGO.
Dr. MANLY.
>> GOOD MORNING, EVERYONE.
I'M JENNIFER MANLY AND I'M A
NEUROPSYCHOLOGIST AND A
RESEARCHER AND A PROFESSOR AT
COLOMBIA UNIVERSITY IN NEW YORK.
I DO WORK ON COMMUNITY-BASED
RESEARCH BOTH IN WASHINGTON
HEIGHTS AND IN THE NORTHERN TIP
OF MANHATTAN, HAMILTON HEIGHTS
AND INWOOD AND WE HAVE A COUPLE
OF COHORTS OF PEOPLE WHO WE
FOLLOW OVER TIME WHO WERE AGING
AND WHO ARE BLACK AND AFRICAN
AMERICAN, HISPANIC OR LATINO AND
NON HISPANIC AND WHITE.
AND WITH THAT WORK, WE'RE HOPING
TO UNDERSTAND SOME OF THE LIFE
COURSE, SOCIAL AND STRUCTURAL
DRIVERS OF LATER LIFE COGNITIVE
FUNCTION.
AND INEQUALITIES IN ALZHEIMER'S
DISEASE RELATED DEMENTIA.
>> THANK YOU Dr. MANLY.
Dr. PETERSON.
>> GOOD MORNING, I'M CHARLOTTE
PETERSON A PROFESSOR AT THE
UNIVERSITY OF KENTUCKY AND MY
MAJOR RESEARCH OVER THE LAST
YEARS HAS BEEN ON CELLULAR AND
MOLECULAR MECHANISMS REGULATING
SKELETAL MUSCLE ADAPTATION, TO
ADAPT AND THE LOSS OF THAT
ABILITY WITH AGE SO MY RESEARCH
INVOLVES MUSCLE CELLS AND
CULTURE TO GENETIC MOUSE MODELS
TO EXERCISE STUDIES IN HUMANS
THROUGHOUT THE LIFE COURSE.
>> THANK YOU.
AND WELCOME Dr. PETERSON.
Dr. RUBEN.
>> HI, I'M DAVE RUBEN AND I'M A
GER TRYING AN AT THE UNIVERSITY
OF LOS ANGELES WHERE I LEAD THE
GERIATRIC PROGRAM AND I'M A
HEALTH SERVICES AND
IMPLEMENTATION SCIENTIST AND I
LIKE TO MONKEY AROUND IN
HEALTHCARE SYSTEMS TO IMPROVE
THE QUALITY OF CARE.
>> I'M A PROFESS OFFER NEUROLOGY
AS WELL AS NEURO PATHOLOGY AND I
SPENT MY TIME DOING NEURO
PATHOLOGY RATHER THAN NEUROLOGY.
SO, I'M INTERESTING IN THE NEURO
PATHOLOGY OF AGING, ESPECIALLY
DEMENTIA AND USING WHAT WE SEE
IN THE BRAIN TO INFORM ON THIS
FACTOR MECHANISMS, PROGRESSION
AND LATELY I'VE BEEN INTERESTED
IN USING NEURO PATHOLOGY TO
INFORM ON BIOMARKERS.
>> Dr. VAN ELDIK.
>> HI, EVERYONE, I'M A PROFESSOR
OF NEUROSCIENCE AND DIRECTOR OF
SANDRA BROWN CENTER ON AGEING
AND THE ALZHEIMER'S DISEASE
CENTER AT UNIVERSITY OF
KENTUCKY.
MY OWN RESEARCH IS STUDYING
DIS-REGULATED BRAIN INFLAMMATION
AND USING IT AS A TARGET TO
TRANSLATE OUR BASIC SCIENCE INTO
THERAPEUTICS THAT ARE CURRENTLY
IN HUMAN CLINICAL TRIALS.
>> THANK YOU, Dr. VAN ELDIK
AND WELCOME TO COUNCIL.
Dr. WEIR.
>> I'M A RESEARCH PROFESSOR IN
THE INSTITUTE FOR SOCIAL
RESEARCH AT THE UNIVERSITY OF
MICHIGAN AND I'M DIRECTOR OF THE
HEALTH AND RETIREMENT STUDY AT
CO-OPERATIVE AGREEMENT WITH NIA
AND WORKING ON BUILDING AN
INTERNATIONAL NETWORK OF
HARMONIZED POPULATION STUDIES OF
DEMENTIA.
>> THANK YOU, Dr. WEIR AND
Dr. WHITFIELD.
>> CLEAN UP.
GOOD MORNING, EVERYONE, I'M
KEITH WHITFIELD, I SEARCH AS THE
PRESIDENT OF THE THE UNIVERSITY
OF LAS VEGAS AND PSYCHOLOGY AND
BRAIN HEALTH AND MY RESEARCH IS
ON INTERFACES BETWEEN COGNITION,
AND HEALTH DISPARITIES AND IN
AFRICAN AMERICANS USING TWIN
FAMILY INDIVIDUALS TO UNDERSTAND
THOSE INTER RELATIONSHIPS AND
CURRENTLY I'M WORKING ON A STUDY
OF STRESS AND LONGEVITY.
THANK YOU.
>> THANK YOU, Dr. WHITFIELD.
AND WE ALSO HAVE SOME NEW
MEMBERS, OUR EX-OFFICIO MEMBERS.
Dr. ORDWAY.
>> I'M A PROGRAM SPECIALIST AT
THE NATIONAL INSTITUTE OF
DISABILITY INDEPENDENT LIVING
AND REHABILITATION RESEARCH IN
THE ADMINISTRATION FOR COMMUNITY
LIVING.
AND I LEAD NIDLER'S RESEARCH
PORTFOLIO AT INTERSECTION OF
AGING AND DISABILITY SO THESE
ARE INDIVIDUALS AGING INTO AND
WITH DISABILITY AND PRIOR COMING
HERE I STUDIES DISABILITY ACROSS
THE LIFESPAN.
I SHOULD MENTION MY COLLEAGUE,
RODA IS NOT HERE.
>> THANK YOU, WELCOME TO OUR
COUNCIL.
THANK YOU.
SO, NOW I'LL TURN THE MEETING
OVER TO OUR DIRECTOR, Dr.
RICHARD HODES.
>> THANK YOU, WELCOME TO OUR
ESTEEMED COUNCIL AND THANK YOU
FOR JOINING US THIS MORNING.
I'D LIKE TO GIVE YOU SOME BRIEF
UPDATES OF THE SOME OF THE
THINGS THAT WE HEARD AT OF THE
LAST COUNCIL MEETING AND WE'LL
THEN PAUSE FOR DISCUSSION BEFORE
WE INTRODUCE SOME OF THE NEW
ARRIVED STAFF HERE AT NIA.
IF WE CAN HAVE THE SLIDES,
PLEASE.
ONTO THE NEXT SLIDE.
SINCE WE LAST MET IN JANUARY, WE
HAVE RECEIVED AN APPROPRIATION
WHICH PROVIDED A TOTAL OF
$45 BILLION FOR NIH THAT WAS AN
INCREASE TO A TOTAL OF SOME
$4.2 BILLION FOR NIA.
THIS INVOLVED, AS YOU SEE, A
TARGETED INCREASE OF
$289 MILLION FOR ALZHEIMER'S
RELATED DEMENTIA RESEARCH AND
SOME OF THE OTHER TARGETED
RESEARCH INCREASES AROUND NIH
RELEVANT TO US INCLUDE THOSE FOR
THE ALL OF US POPULATION THE
BRAIN INITIATIVE, AND FOR DOWN
SYNDROME AND ALL OF WHICH NIH
PARTICIPATES AND IN ADDITION
THERE WAS AN INCREASE ACROSS THE
BOARD WHICH WILL PROVIDE
INCREASES RESOURCES FOR ALL OF
OUR DIVISIONS IN THE FULL
SPECTRUM OF NIA SUPPORTED
RESEARCH.
THIS IS AN ELEVATION OVER TIME
OF THILLUSTRATION THAT NIAHAS SEEN WITH IN CREASED
APPRECIATION BIPARTISAN, FOR THE
IMPORTANCE OF AGING ALL ASPECT
APPROXIMATES OF AGING RESEARCH
INCLUDING NOTABLY THE TARGETED
FUNDING WE'VE SEEN WITH
ALZHEIMER'S AND RELATED DEMENTIA
DEMENTIA.
THIS IS JUST TO SHOW YOU YEAR
UPON YEAR THE INCREASES WE
RECEIVED THAT HAVE BEEN TARGETED
TO ALZHEIMER'S AND THE MOST
RECENT $9 MILLION WE JUST SHOWED
YOU BUT IN PARTICULAR IN 2016,
THESE LARGE SUMS WHICH HAVE
GIVEN BASE OF RESOURCES THAT WE
NOW HAVE.
AT THIS POINT OF THE YEAR WE
HAVE A INTERIM PAY LINE FOR
COMPETING GRANTS TO THE AWARDS I
CAN SHARE WITH YOU FOR THE CSR
REVIEWED RESEARCH APPLICATIONS
PER ALZHEIMER'S RELATED
DIMENSION RESEARCH YOU CAN SEE
AT RIGHT, THE PAY LINES LAST
YEAR ARE TO THE 28th
PERCENTILE WITH INCREASES
PERCENTILE FOR THE NEW
INVESTIGATOR AT ESI, EARLY STAGE
INVESTIGATORS RESPECTIVELY THE
31st AND 33rd PERCENTILE AND
THE GENERAL PAY LINE, TENTH
PERCENT WOULD AGAIN 13th AND
15th FOR NI AND ESI AND WE
HAVE A HIGHER BAR FOR THE
GENERAL PAY LINE FOR THE MORE
EXPENSIVE APPLICATION OVER
$500,000.
WE'RE HOPEFUL AND IT'S POSSIBLE
AS THE YEAR GOES ON WE'LL REVISE
THESE IN AN UPWARD DIRECTION BUT
AT PRESENT, THESE ARE THE
INTERIM PAY LINES.
AND FOR NIA REVIEWED
APPLICATIONS THEY HAVE A
PRIORITY SCORE WHERE YOU CAN SEE
FOR AD RESEARCH AND THESE PAY
LINES OF 40 FOR PROGRAM PROJECT
AND OTHER NIA REVIEW RESEARCH
AND SOMEWHERE IN THE PRIOR YEARS
AND YOU CAN SEE THE LOWER PAY
LINES FOR THE GENERAL CATEGORY
BUT I NOTE HERE IN THE CAREER
DEVELOPMENT AND FELLOWSHIPS OF
TRAINING AREAS, WE HAVE OF A
LESSER GAP AS WE GIVEN
PRIORITIES AND EVEN TIMES IF CON
TRAINED RESOURCES TO THE EARLY
STAGES OF TRAINING AND CAREER
DEVELOPMENT AND AGAIN AS THE
YEAR PROGRESSES, WE CAN HOPE FOR
INCREASES IN THESE PAY LINES.
AS WE RECRUITED RESEARCH IN THE
AREA OF AD AND ADRD IT'S BEEN
IMPORTANT TO TRACK THE SUPPORT
WE HAVE FOR THE VERY TALENTED
AND ABLE INVESTIGATORS ALREADY
IN THE FIELD, BUT TO RECRUIT NEW
INVESTIGATORS INTO THE FIELD SO
FROM 2015, THE LARGE INCREASES
BEGAN THROUGH 2021.
ABOUT A THIRD OF THE ADADRD
AWARDEES WERE NEW OR ARTICLE
STAGES INVESTIGATORS EARLY IN
THEIR CAREER.
EQUALLY STRIKING.
A FOURTH WERE NEW TO THE FIELD.
THAT DEFINITION IS THEY NEVER
APPLIED FROM RESEARCH FOR NIH
FOR THESE AREAS OF RESEARCH SO A
GROWING FIELD INCLUDING THE
RECRUITMENT WHICH IS IMPORTANT
NEW AND VITAL TALENT INTO THE
RESEARCH COMMUNITY.
JUST TO SHOW AS AN EXAMPLE OF
WHERE WE ARE IN NIA/ADRD IN
CLINICAL TRIALS THERE ARE 70
TRIALS.
62 OF THEM, IT'S NOTABLE THAT
MORE THAN 3/4 OF THESE ARE TO
TARGETS OTHER THAN AM A LLOYDS
SO AS OUR DISCOVERY OF NEW
MECHANISMS AND THE OPPORTUNITIES
TO IDENTIFY NEW TARGETS AS
PROGRESSED, THESE ARE MOVING
INTO CLINICAL TRIALS NOW AND
THEY'RE TRIALS TO LATE STAGE,
THOSE AT POINT OF BEING MOST
READY TO PRODUCE DEFINITIVE
FINDINGS THERE ARE EIGHT, FIVE
OF WHICH ARE AMYLOID AND WE'RE
SEEING THE NON TARGETING AS WELL
AND TARGETING AMYLOID AND
ADDRESSING NEW TARGETS AND NEW
TRIALS AS WELL.
THERE ARE MORE NON PHARMACOLOGIC
AND 132 AT PRESENT WITH EXERCISE
AND COGNITIVE TRAINING AND THESE
ARE AREAS THAT ARE RECENT REVIEW
WHO ARE IDENTIFIED AS THE
PARTICULARLY PROMISING BUT ALSO
OTHER TARGETS INCLUDING
COMBINATIONS, NEURO
STIMULATIONS, SLEEP RELATED
INTERVENTIONS AND DIET.
STUDIES DIRECTED AT DEMENTIA
CAREGIVING INCREASES TO 187 AND
AN INCREASE IN RECENT YEARS AS
WE'VE RECOGNIZED THROUGH REPORTS
OF EVALUATIONS AND OUR OWN SUM
ITS, THE NEED FOR RESEARCH IN
THESE AREAS AND OTHER TRIALS AT
DIAGNOSTIC AND A TREATMENT OF
THE NEURO PSYCHIATRIC SYMPTOMS
THAT ACCOMPANY AD AND RD
DEMENTIAS.
I WANTED TO LET YOU KNOW WE HAVE
SEEN THE OPENING ON THE NIH
CAMPUS OF CARD THAT'S THE CENTER
FOR ALZHEIMER'S RELATED DEMENTIA
AND THIS IS A JOINT CENTER AND
THAT BANG KNOWING OUR
APPROPRIATION AND WE'RBEING IN OUR APPROPR IATIONAND ROY BLUNT CENTER.
IT'S AN EFFORT AT NIA AND ALSO
TAKES ADVANTAGE OF THE FACT ON
THE NIH CAMPUS, WE CAN LEVERAGE
THE SKILLS, PERSPECTIVES OF ALL
OF THE NIH INSTITUTES AND THEIR
INTERMURAL CAMPUS, INCLUDING THE
CLINICAL CENTER WITH
EXTRAORDINARY OPPORTUNITIES IN
AREAS OF IMAGING OR GENE THERAPY
AND TRANSLATIONAL AND BASIC
SIGNS THASCIENCE THAT SPAN THE NIH
SPECTRUM.
PARTICULAR OPPORTUNITIES INCLUDE
NEW TRAINING MECHANISMS FOR
TRAINING AND AREAS OF INFORM
ATTICS AND OTHER KEY EMERGING
AREAS AND OPPORTUNITIES FOR
VISITING SCIENTISTS IN THE FORM
OF BOTH PRIVATE SECTOR ACADEMIC
WHO CAN SPEND TIME IN THE
CREATIVE INCUBATOR OF THE
COLLEGE CENTER AND THE NEW
SCHOLARS PROGRAM THAT HAS BEEN
ANNOUNCED.
AS EXAMPLE OF THE RESEARCH,
ABOVE ALL THE PARADIGM IS DATA
GENERATION, DATA SHARING AND
INFRASTRUCTURE AND SUPPORT
RESEARCH IN THESE BROAD AREAS
AND JUST ONE HIGHLIGHT FOR
EXAMPLE IS THE GENERATION OF
IPSL LINES AND ARE TARGETED FOR
MUTATION THIS IS MULTIPLE
CANDIDATE TARGETS INVOLVED IN
ALZHEIMER'S-RELATED DEMENTIA AND
INDUCTION OF MUTATIONS AND
REVERT ANTS CREATING A LARGE
PAIN ELF ISL AND AS IS ALL THE
DATA BEING ACCUMULATED AND WE
LOOK FORWARD TO GIVING YOU
UPDATES ON THIS ENTERPRISE AS WE
MOVE FORWARD.
THANK YOU, NEXT SLIDE, PLEASE.
ANOTHER INNOVATIVE PROGRAM
TAKING ADVANTAGE OF THE SPIR AND
THE SMALL BUSINESS ENTERPRISES
AND THE IMPORTANT OPPORTUNITIES
THESE CREATION FOR TRANSLATIONAL
RESEARCH IS SHOWN HERE.
I START UP CHALLENGE IN
BOOTCAMP.
WHICH WILL LOOK TO FOSTER
DIVERSITY IN THE WORKFORCE AND
INNOVATION BY PROVIDING FUNDS
THAT ASSIGN ENTREPRENEURS TO
INVESTIGATORS AS A COMPETITIVE
PROGRAM AND WE'LL LOOK AT
APPLICANTS AND THEY WILL BE
PAIRED WITH ENTREPRENEURS AND
THROUGH BOOTCAMP WHICH IS PARTLY
PERSONAL AND IT MAKES THEM
STRONGER CANDIDATES FOR
SUBMISSION OF RESEARCH IN THIS
AREA WITH ON GOING EXPERT FROM
EXPERTS AND THE SCIENCE BUSINESS
TRANSLATION.
WE SEARCH HIGHLIGHTS AND BLOGS
AND PRESS RELEASES AND ALSO THE
ATTEMPTS SOME OF US HAD TO
PROMOTE THIS COMMUNICATION BY
MULTIPLE MEETINGS WITH
STAKEHOLDERS, ADVOCACY GROUPS
AND CON GREG A LOT BRIEFINGS AND
HEARINGS TO COME.
NEXT, PLEASE.
I WANT TO TAKE A MINUTE TO
ACKNOWLEDGE THE LOSS TO ALL OF
US OF JOHN.
JOHN WAS AN IMPORTANT AND
COMPASSIONATE MENTOR AND NEVER
FAILING ADVOCATE WHO SERVED ME
ENORMOUSLY AND MANY OF US HAVE
THAT SHARED EXPERIENCE.
HIS CONTRIBUTIONS TO THE FIELD
HAVE BEEN ENORMOUS AND TO NIH
AND NIA IN PARTICULAR AND
INCLUDING SERVING ON THE CALL OF
SCIENTIFIC COUNCILORS AND THIS
ADVISORY COUNCIL WE STAND TO
NOW.
SO BEFORE MOVING ON, LET ME JUST
TAKE A MOMENT SO WE CAN ALL
PAUSE TO REFLECT ON JOHN'S
CONTRIBUTION.
THANK YOU, I WISH THE BEST TO
VIRGINIA LEE AND THOSE WHO WILL
LIVE ON.
NIH UP DATES, A LITTLE ABOUT
ARPAH.
THERE'S BEEN A LOT HEARD AND
SOME PROGRESS TOWARDS DEFINING
WHAT IT APPEARS ARPAH LOOKS
LIKE.
IT DERIVES FROM THE DARPA MODEL
AND IT HAS CHARACTERISTICS AND
HIGH REWARD RESEARCH AND SHORT
TERM GOAL ORIENTED AND QUICK TO
REACH MILESTONES FOR GOAL AND
NO-GO DECISIONS AND THE DIRECTOR
AND THE PROGRAM PROJECT OFFICERS
ARE APPOINTED FOR LIMITED TERMS
AND THERE'S A MOTIVATED AND IT
GENERATES RAPID TURN AROUND AND
AREAS THAT RANGE FROM
TECHNOLOGY, AND COMPLIMENTARY TO
OF NIH AND ITS RESOURCES, A LOT
OF ATTENTION TO EMPHASIZE THIS
POINT IS NOT ANOTHER NIH
INSTITUTE, IT HAS ITS OWN
PERSPECTIVE AND ITS OWN
INDEPENDENT APP AND INTER
DEPENDENCE.
NEXT SLIDE, PLEASE.
WE'LL EMPHASIZE SOME OF THESE
AND WORE LOOKING FOR INNOVATIVE
AND COLLABORATIVE IDEAS, NIMBLE,
URGENT AND TIME BOUND AND
LIMITED OPEN TO TRANSPARENT
ENGAGEMENT AND STAKEHOLDERS AND
SEEKING BOLDNESS WITH OUT SIZED
IMPACT THIS IS THE MANTRA IF YOU
WILL OF DARPA AND ARPA-H.
A LITTLE BIT OF HISTORY EXPLAINS
HOW WE GOT TO WHERE WE ARE.
THE SUMMER OF LAST YEAR, OSTP
AND NIH PUBLISHED A COMMON TAR
EVE WHAT ARPA-H MIGHT LOOK LIKE,
MARCH OF THIS YEAR CONGRESS
PASSED AND THE PRESIDENT SIGNED
A FY22 ON THIS LEGISLATION A
BILLION DOLLARS AVAILABLE FOR
THREE YEARS AND IT DETERMINED
THAT THE DIRECTOR OF ARP A-HP
WOULD BE APPOINTED WITH
FLEXIBILITIES TO THE PROGRAM AND
JUST LAST MONTH, THE DECISION OF
THE ADMINISTRATION AND THE
DEPARTMENT WAS THAT ARPA-H WOULD
BE TRANSFERRED TO NIH, THIS WAS
PERMISSIBLE IN LEGISLATION AND
IMPORTANTLY HOWEVER THE ARPH-A
DIRECTOR WILL REPORT TO THE
SECRETARY NOT THE NIH DIRECTOR
AND THERE'S AUTHORIZED
$5 BILLION IN THE FY-23
PRESIDENT BUDGET REQUEST AND
THIS IS THE PRESIDENT'S BUDGET
JUST PRESENTED NOT YET
LEGISLATED SO WE'LL SEE WHERE
THIS TURNS OUT SO IT'S IMPORTANT
FOR US ALL OF US TO TRACK AND
LOOK AT CONTRIBUTION THAT'S WILL
SYNERGIES FOR ALL OF US AT NIH.
I'D LIKE TO PAUSE HERE AS I
SAID, BEFORE WE INTRODUCE SOME
OF THE NEW STAFF THAT HAVE
JOINED US, LET ME DID IN FACT
ENCOURAGE YOU TO INITIATE
QUESTIONS, DISCUSSIONS ABOUT
ANYTHING THAT I'VE TALKED ABOUT
AND ANYTHING ELSE YOU WOULD LIKE
TO BRING UP ABOUT ALL OF US AND
OUR SHARED INTERESTS.
OPEN FOR QUESTIONS AND COMMENTS,
PLEASE.
>> CAN I ASK A QUESTION?
>> OF COURSE.
>> I JUST WONDERED WHETHER YOU
COULD SHARE DETAILS OF THE
ARPA-H.
IT'S GETTING INCORPORATED INTO
NIH AND WHETHER THAT WILL
UTILIZE SOME OF THE
INFRASTRUCTURE OF FUNDING AND
REVIEWING AND THINGS THAT ARE
ALREADY IN PLACE, WHICH I COULD
IMAGINE WOULD HAVE BENEFITS AND
ALSO POTENTIALLY DRAW-BACKS.
>> THANK YOU.
YOU HAVE A REAL SENSITIVITY.
ARPA-H IS NOT A PART OF NIH.
IT WILL -- IT'S A PART OF HHS
AND THE DIRECTOR REPORTS TO THE
SECRETARY, NOT THE NIH DIRECTOR.
THERE'S ACTUAL DISCUSSION
LEGISLATIVE PROPOSALS AND
PHYSICALLY SOME ARGUING THAT IT
SHOULD BE PERMITTED TO RESIDE
ONLY AND NOT IN THE WASHINGTON
BETHESDA AND -- THAT THINK IS
SYMBOLIC FOR THE SENSITIVE FOLKS
AND THERE IS AN IMPORTANT
SEPARATION BETWEEN NIH AND
ARPA-H BUT SOME OF THE POINTS
WHETHER THERE'S INFRASTRUCTURE.
AS EXAMPLE IT WAS PRESSED THE
NUMBER OF ADMINISTRATOR
FUNCTIONS FOR GRANT REVIEW AND
FOR GRANT ADMINISTRATION, AT NIH
ARE USED FOR ARC, FOR CDC AND A
NUMBER OF AGENCIES SO IT'S
POSSIBLE THEY WILL USED TO
FACILITATE AND AS LONG AS IT'S
NOT CONFUSED WITH CONFOUNDING OF
WHAT IS TO BE THE UNIQUE MISSION
OF ARPA-H, WE'LL ALL PAY
ATTENTION TO HOW WE DEFINE AND
REFINE THIS BALANCE BETWEEN
MAINTAINING SEPARATION AND
UNIQUENESS BUT NOT LOOSE THE
ADVANTAGE OF COMMUNICATION WITH
NIH AND ALL OF YOU.
>> THANK YOU.
>> OTHER RESOURCES AT THE NIH
WILL BE UTILIZED.
WE DON'T HAVE TO REPEAT AND HAVE
BERRY EFFICIENCIES STANDING UP A
NEW INSTITUTE AND I'M NOT SURE
WHAT THIS WOULD BE CALLED WHEN
IN ADDITION TO NIH, BUT FOR
INSTANCE, OUR ERA COMMENTS AND
ALL OF OUR ELECTRONIC RECEIPT
FOR USING GRANT SUBMISSIONS AND
ALL THOSE TYPES OF THINGS, WILL
BE UTILIZED BY ARPA-H AT THIS
POINT TOO SO THEY'RE CERTAINLY
GOING TO USE THE RESOURCES BUT
IT'S GOING TO BE SEPARATE FROM
THE NIH.
Dr. WHITFIELD?
>> YES, THANK YOU, VERY MUCH FOR
THAT, RICHARD.
THERE IS SO MUCH BETTER MONEY
RUNNING AROUND AND DIFFERENT
WAYS.
IT'S INTERESTING AND CONFUSING
AT THE SAME TIME.
MY QUESTION IS, DO WE KNOW IF
THIS IS GOING TO BE ONE-TIME
FUNDING OR IS THIS GOING TO BE
SOMETHING THAT IS GOING TO BE A
BUILD-OUT THAT WILL HOPEFULLY
STAY IN PLACE OVER THE TIME.
I SAW THE SECOND AMOUNT THAT YOU
HAD THERE WAS $5 BILLION, AND
WONDER IF IT HAS TO BE SPENT OUT
IN SOME SPECIFIED PERIOD OF TIME
OR WHETHER THIS IS GOING TO BE A
NEW ELEMENT OF NIH.
>> THIS IS ALL PRELIMINARY AND I
CAN SPEAK FROM WHAT I KNOW AND
MAYBE UNDERSTAND OR ASSUME BUT
FIRST TO NOTE THE APPROPRIATION
THIS YEAR, FY22 FOR ONE BILLION
DOLLARS, WHICH IS LEGISLATED,
ALLOWS THAT MONEY TO BE SPENT
OVER THE NEXT THREE YEARS
RECOGNIZING THAT THE SPEND A
BILLION DOLLARS IN THESE NEXT
FEW MONTHS WOULDN'T WORK.
I THINK THE LONG-TERM
LEGISLATION INCLUDING THAT
PROPOSED BY THE PRESIDENT FOR
FY-23, PRESUMES THIS IS A
LONG-TERM COMMITMENT AND THAT
WILL BE AS PROPOSED AND ANNUAL
BUDGET.
WE'LL SEE HOW THAT TURNS OUT
WHEN THE LEGISLATION GOES
THROUGH CONGRESSIONAL APPROVAL
BUT YES, I THINK ALL ARE
INTERPRETING THIS TO BE A
LONG-TERM INVESTMENT, A
LONG-TERM AGENCY.
>> OTHER QUESTIONS FOR Dr.
HODES?
>>
>> IF JOHN WAS WITH US, I KNEW
HE WOULD HAVE QUESTIONS.
>> FOR SURE.
>> WE'LL HAVE TO STAY TUNED TO
SEE HOW ARPA-H WILL COMPLIMENT
WHAT IS GOING ON HERE AT NIH AND
WE KNOW THERE'S MANY MEETINGS
GOING ON LED BY Dr. TARA
SCHWARTZ AT NIH.
SHE'S ONE OF THE DEPUTY
DIRECTORS AT THE NIH AND LOOKING
AND COORDINATING WITH ALL THE
INSTITUTES AND CENTERS HERE AT
NIH.
TO MAKE SURE WE'RE COMPLIMENTARY
AND NOT OVERLAPPING SO STAY
TUNED WHEN WE HEAR MORE
INFORMATION, WE'LL ADVISE YOU
ALL.
>> LET ME KNOW IF YOU HAVE MORE
QUESTIONS, OTHERWISE WE'LL TURN
TO THE ENJOYABLE NEXT TASK OF
INTRODUCING NEW NIA STAFF.
>> THANK YOU, RICHARD.
IN THE DIVISION OF AGING
BIOLOGY, OVER THE PAST 12 MONTHS
WE'VE ADD EIGHT NEW STAFF.
MOST RECENT TWO SHOWING HERE.
Dr. GAO IS A PROGRAM OFFICER
MANAGING CARDIAC AND PULMONARY
AND VASCULAR PORTFOLIO AND Dr.
TILAHUN HAS THE IMMUNOLOGY
PORTFOLIO TAKEN OVER AFTER THE
RETIREMENT OF REBECA FULLMER.
>> THANK YOU, FROM DIVISION OF
BEHAVIORAL AND SOCIAL RESEARCH,
WE HAVE FOUR NEW FOLKS.
FIRST, A HEALTH SPECIALIST AND
SHE'LL BE SUPPORTING AND
DEVELOPING DATA LINKAGE IRIM
AZAM IN THE OFFICE OF DATA
RESOURCE AND IRIM COMES TO US
FOR WORKING FOR A DECADE FOR THE
AGENCY RESEARCH AND EQUALITY
WHERE SHE SERVED ON PATIENT
SAFETY TEAM AND THE NATIONAL
HEALTHCARE QUALITY AND REPORTS
TEAM.
SHE HAS HER BACHELORS IN
PSYCHOLOGY AND BIOLOGICAL
SCIENCES FROM AND A MASTER IN
PUBLIC-HEALTH.
LIZA ZEINERT JOINED US FROM
CLINICAL TRIALS AND SHE WORKED
PREVIOUSLY AT NIADA FOR A COUPLE
TESTIFY DECADES LEADING
CONFLICTS CLINICAL TRAILS
OPERATIONS MANAGEMENT FOR A
LARGE-SCALE MULTI SITE TRIALS
AND CONDUCTED IN AND SHE'S TAKING A
ROLE AND SHE HAS HER BACHELORS
IN FAMILY AND COMMUNITY STUDIES
WITH A DOUBLE MAJOR IN
PSYCHOLOGY FROM SER ACCUSE
UNIVERSITY AND BACHELORS IN
PSYCHOLOGY.
KATE LYNN LEE JUST JOINED US AS
A HEALTH POPULATION.
SHE'S PREVIOUSLY SERVED IN
PUBLIC-HEALTH POSITIONS AT
OREGON AND IN COLORADO AND
NOTABLY TRACKING COVID-19
OUTBREAKS THERE AND SHE PAROLE
HAD A FELLOWSHIP AT NIAID IN
THEIR OFFICE OF AND THERESA KIM
JOINED AS A SOCIAL BEHAVIORAL
SCIENTIST ADMINISTRATOR AND
SHE'S MANAGING A RESEARCH
PORTFOLIO IN HEALTH SYSTEMS
RESEARCH WITH A FOCUS ON
INTERVENTIONS.
SHE HAS STATISTICAL GENETICS
POPULATION HEALTH AND GLOBAL
HEALTH BACKGROUND RELATED TO
TOPICS SUCH AS ALCOHOL AND DRUG
ABUSE, REPRODUCTIVE HEALTH AND
RESEARCH INFRASTRUCTURE.
PRIOR TO COMING TO BSR, SHE WAS
AT PA CORY TO IMPROVE CLINICAL
EFFECTIVENESS RESEARCH AND
PATIENT-CENTERED OUTCOMES
RESEARCH.
SHE HAS A PH.D IN HEALTH SERVICE
AND A MASTERS IN BIO STATISTICS
FROM THE UNIVERSITY OF
WASHINGTON.
THANK YOU AND WELCOME TO ALL OF
THEM.
>> GOOD MORNING, AND THANK YOU
FOR THE OPPORTUNITY TO INTRODUCE
OUR STAFF AT THE DIVISION OF
NEUROSCIENCE.
WE ALSO HAVE RECRUITED ABOUT
EIGHT NEW MEMBERS TO THE TEAM
SINCE THE BEGINNING OF THE YEAR
AND I'M INTRODUCING THREE OF
THEM THAT RECENTLY JOINED US,
FIRST IS CHELSEA HAAKENSON.
SHE'S JOINING THE BRANCH OF
NEURO IDEOLOGY OF AGEING AND
NEURO DEGENERATION AND SHE'LL BE
SUPPORTING THE MANAGEMENT OF
PROGRAMS ON ALZHEIMER'S DISEASE
RELATED DEMENTIA AS RELEVANT TO
MECHANISMS OF DISEASE.
SHE'S GRADUATE STUDENT AT
UNIVERSITY OF MARYLAND AND
EXPECTING TO GET HER PH.D THIS
MONTH ON NEUROSCIENCES AND
COGNITIVE SCIENCES.
IN THE BEHAVIOR -- WE HAVE
JOINING US CAROLINE SFERREAZZA
AND SHE WILL BE SUPPORTING
RESEARCH THAT THE BRAN IN
MANAGEMENBRANCHMANAGING ON SENSORY MODEL A ND
COGNITIVE NEUROSCIENCES AND
CAROLINE PREVIOUSLY WAS A SENIOR
ASSOCIATE AT ROSA LEE AND SHE
HAS A SIGNIFICANT TRAJECTORY ON
NEUROSCIENCE AND I'M HAPPY TO
HAVE HER.
AND THEN FINALLY, RECENTLY
JOINING IS MARIA FELANFRANCO
GALLOFRE AND SHE WILL JOIN ON
TRANSLATIONAL RESEARCH AND
PROVIDING SUPPORT ON PROGRAMS
RELATED TO DRUG DISCOVERY AND
DRUG DEVELOPMENT AND
PARTICULARLY ON INFRASTRUCTURE
PROGRAMS OF TRANSLATION.
SHE ALSO WILL BE INVOLVED IN ALL
THE WORK THAT IS NEEDED FOR
CURATING A LOT OF THE DATABASES
THAT WE HAVE ON THE CLINICAL
RESEARCH AND DRUG EFFICACY AND
SHE HAS A PH.D AND HAD BEEN
INVOLVED ON SCIENTIFIC PROGRAMS
THAT COLUMBUS TECHNOLOGY AND
SERVICES.
>> I WILL INTRODUCE SEVERAL NEW
MEMBERS.
FIRST OFF, I'D LIKE TO INTRODUCE
A NEW BRANCH MANAGEMENT
SPECIALIST NATISHA ROWE AND
JOINS US ON THE NATIONAL
INSTITUTE OF DRUG ABUSE, OFFICE
OF EXTRAMURAL POLICY AND RENEW
AND NEXT IS FALASADE ONIRETI AND
SHE'S A GRANTS MANAGEMENT
SPECIALIST AND SHE'S JOINING US
FROM THE CHILDREN'S HOSPITAL,
CHILDREN'S NATIONAL HOSPITAL.
WE HAVE DIANNE MURRILL AND SHE
IS A GRANTS MANAGEMENT
SPECIALIST JOINING US FROM THE
U.S. DEPARTMENT OF STATE.
AND THESE WILL BE OVERSEEING THE
DAY-TO-DAY MANAGEMENT OF GRANTS,
FORT FOALPORTFOLIOS.
WE ALSO HAVE LUCKY TO HAVE
PHILLIP SMITH AND HE IS ONE OF
OUR NEW SUPERVISORS REGRANTS
MANAGEMENT SPECIALISTS AND FOR
NON PRAG ATTIC AS RESPECTS AT
NIA AND HE JOINS US FROM THE
OFFICE OF POLICY AND EXTRAMURAL
RESEARCH ACTIVITIES AT THE
OFFICE OF THE DIRECTOR HERE AT
THE NIH.
WE ALSO HAVE KEVIN CRIST AND HE
WILL BE A GRANTS MANAGEMENT
SPECIALIST.
ALSO JOINING US FROM THE U.S.
DEPARTMENT OF ENERGY.
NEXT SLIDE.
WE ALSO WERE HAPPY TO HAVE SHE
WORKS DIRECTLY WITH TODD HYMN
AND AS OUR DIRECTOR, AND
COORDINATES OFFICE ACTIVITIES
AND PROGRAMS DEALING WITH
TRAINING, CAREER DEVELOPMENT AND
SMALL BUSINESS PORTFOLIOS AND
SHE'S JOINING US FROM THE NIH
OFFICE OF EXTRAMURAL RESEARCH.
WE ALSO HAVE JAMIE LAHVIC A
PROGRAM OFFICER IN THE OFFICE OF
STRATEGIC EXTRAMURAL PROGRAMS.
WORKING UNDER SHOSHANA AND TODD
HYMN AND SHE WILL MANAGE THE
COMMUNICATIONS WITH NIA EMERGING
RESEARCHERS AND NEW INITIATIVE
DEVELOPMENT AND PROGRAM
EVALUATIONS DEALING WITH OUR
TRAINING PROGRAMS AND SHE'S
PREVIOUSLY A TRIPLE A SCIENCE
AND TECHNOLOGY FELLOW AND JUST
JOINED THIS OFFICE RECENTLY.
I'LL TURNOVER.
>> THANK YOU, KEN, APPRECIATE
THAT.
GOOD MORNING, EVERYBODY, THIS IS
INWARD FACING ORGANIZATION
WITHIN NIA THAT HANDLES OR
WORKFORCE PLANNING AND HUMAN
CAPITAL DEVELOPMENT.
I'M HAPPY TO HAVE HALEY LAFFERTY
SUPPORTING OUR DIVISION OF
BIOLOGY FROM THE NIH HUMAN RE
SOURCE OFFICE AND WE HAVE
ZENAIDA CAMMAS AND SHE COMES TO
US FROM THE NATIONAL NIH OFFICE
OF HUMAN RESOURCES AND JEJELOLA
ORSENAYA COMES FROM THE
WORKFORCE DIVERSITY OFFICE AND
AS A PART OF OUR OPERATIONS AND
EXPANDING RESPONSIBILITIES IN
TERMS OF PERFORMANCE MANAGEMENT
ACTIVITIES AND EXECUTIVE
PERFORMANCE MANAGEMENT AND OUR
EMPLOYEE OF THE MONTH PROGRAMS
AND SOME OF OUR OPPORTUNITIES TO
INCREASE ENGAGEMENT SO WE'RE
EXCITED TO HAVE ALL THREE JOIN
US.
THANK YOU.
NEXT SLIDE.
HI, I'M CINDY THE NIA
COMMUNICATIONS DIRECTOR AND
DELIGHTED TO WELCOME TO THE
OFFICE OF COMMUNICATIONS AND
PUBLIC LIAISON, KELLY OHAVER,
SHE'S HELPING TO OVERSEE THE NIA
WEBSITE AND OUR VARIOUS
SCIENTIFIC SITES AND SHE IS
SUPPORTING OUR USABILITY TESTING
AND ANNA LET TICK ANALYTICS ON THE WEB SIT ES
AND SHE WAS PREVIOUSLY IN A
LOCAL GOVERNMENT POSITION IN THE
CITY OF CENTENNIAL COLORADO AND
STEPHANIE MORRISON IS A NEW
WRITER/EDITOR IN OUR HEALTH
COMMUNICATIONS BRANCH AND SHE'S
WORKING ON OUR MANY HEALTH
COMMUNICATIONS ON-LINE AND PRINT
PUBLICATIONS AS WELL AS WEBSITE
CONTENT UPDATES AND STEPHANIE
WAS PREVIOUSLY AT NIH NATIONAL
LIBRARY OF MEDICINE WORKING ON
MED LINE PLUS AND GENETICS
REFERENCE MATERIALS.
Dr. ROBIN ARNETT COMES FROM
NIEHS, NATIONAL INSTITUTE ON
ENVIRONMENTAL HEALING SCIENCES.
AND SHE IS WORKING ON PROACTIVE
AND REACTIVE MEDIA RELATIONS
INCLUDING DRAFTING PRESS RELEASE
AND OTHER OUTREACH MATERIALS.
REALLY DELIGHTED TO HAVE ALL
THREE ON BOARD.
THEY'RE ALL REALLY STRONG, NEW
STAFF MEMBERS.
THANK YOU.
>> GOOD MORNING.
>> I'M THE SCIENTIFIC DIRECTOR
OF NIA AND I'M DELIGHTED TO
PRESENT SOME OF OUR MOST RECENT
HIRING MA ROW A FLORIO WAS A
POSTDOC FOR US AND VERY, VERY
SUCCESSFUL.
NOT ONLY GREAT SCIENTIST BUT
ALSO A PROMISE FOR THE FUTURE
AND HER WORK ON CARDIOVASCULAR
DISEASE SO SHE WAS HIRED A
RESEARCH FELLOW AND BASIC
MOLECULAR OF PROGRESSION AND
DIABETES WITH SOME -- AND ANNE
SILL IS AN EPIDEMIOLOGIST IS IS
STARTING THE GROWING OF OUR
TECHNOLOGY AND POPULATION
SCIENCE THAT WE ARE REALLY IN
VERY CLOSE TO EXPAND WITH THE
HIRING ON AT LEAST A COUPLE
OF -- SHE DEVELOPED NEW STUDIES
OR ON GOING RESEARCH AND MANY OF
THE DATABASE AND COHORT THAT ARE
MANAGED BY THIS PROGRAM AND ALSO
ASSIST IN CONTRACT MANAGEMENT
THAT THIS ONE IMPORTANT PART OF
THE WORK OF EPIDEMIOLOGY AND SHE
JOINED US FROM THE HOSPITAL IN
BALTIMORE AND WE WELCOME HER.
CHRISTOPHER DAN IS A BIOLOGIST
AND SHE'S BEEN AT NIA FOR A VERY
LONG TIME AS A CONTRACTOR
WORKING WITH THE UNITS AND THE
FLOW SIGH TOM TER UNIT IS A CORE
FACILITY FOR US AS UNDERGONE A
REALLY MAGIC TRANSFORMATION OF
THE LAST FEW YEARS AND IT'S BEEN
A
THEY GO TO THE LAB AND TALK TO
THE SCIENTISTS AND UNDERSTAND
THE SCIENCE THEY'RE DOING AND
BEING INVOLVED IN THEIR PROJECTS
AND NOT OFFER, NOT ONLY OFFER
TECHNICAL SKILLS BUT YOU KNOW,
ADAPT HIS CONTRIBUTION TO THE IS
THE QUESTION AND HE WAS OFFERED
A POSITION AT NCI WHEN IT WAS A
CONTRACTOR AND I HAD THE
REVOLUTION IN FRONT OF ME OF A
TENURE AND WE WILL KILL YOU IF
HE GOES SO WE DECIDED TO HIM IN
A POSITION OF BIOLOGY AND
FINALLY, WIWA LUI A
ADMINISTRATIVE OVER SERVED AS A
FIRST-TIER CUSTOMER SUPPORT IN
ANSWERING QUESTIONS ABOUT
POLICY, PROCEDURAL AND SYSTEM
INQUIRIES AND DEAL WITH PURCHASE
ORDERS, GLOBAL RECEIVER FOR
PROCESSING INVOICE PAYMENTS AND
MANY OF THE INTERNET CONTENT AND
PROCUREMENT WEB PAGES AND JOINS
US FROM THE NATIONAL CANCER
INSTITUTE.
>> ALL RIGHT.
I JUST WANT TO SAY AWARD AND
COMMENT WE'RE SO THRILLED AND
GREAT TIEGRATIFIED TO WELCOME THIS NEW
STAFF.
YOU WERE HIRED DURING A PANDEMIC
AND SOME OF THEM ARE WORKING
REMOTELY AND SOME OF THOSE NOW
MEETING ONE ANOTHER IN-PERSON
FOR THE FIRST TIME WHICH IS AN
EXTRA LAYER OF EXCITEMENT.
FOR THE YEARS WHEN WE HAD THE
INCREASED BUDGETS AS WE'VE ZONE,
I WANT TO POINT OUT THAT OUR
FTE, OUR PERSONAL CEILING IS
ALSO IN LEGISLATION THERE WAS
SUBSTANTIAL LAG WITH SOMTHERE WASLAG AND W E'VE RECRUITED THESE
TALENTED PEOPLE TO HELP ENGAGE
IN THE EXCITING AND EXPANDING
WORK OF THE INSTITUTE.
I JUST WANT TO MAKE IT CLEAR
THAT WE'RE DELIGHTED AS AN
ORGANIZATION AND WE GET TO MEET
THE STAFFING REQUIREMENTS THAT
YOU HAVE AND IT'S AN EXCITING
TIME AND THANK YOU.
>> ALL RIGHT.
THANK YOU, VERY MUCH, Dr.
HODES AND OF COURSE THE FINAL
SLIDE, JUST, AGAIN, OUR WAYS TO
STAY INFORMED HERE AT THE NIA
FOR OUR BLOGS AND OUR WEB
MATERIAL SO TAKE ADVANTAGE OF
THESE.
SO WE'LL MOVE ONTO THE NEXT PART
OF JUST FOR FUTURE MEETING DATES
FOR COUNCIL.
THE NEXT COUNCIL IS GOING TO BE
ON WEDNESDAY AND THURSDAY
SEPTEMBER 7th AND 8th.
YOU WILL SEE THAT THIS IS WE
WILL HAVE A PERSONAL MEETING IN
SEPTEMBER AND WE USUALLY HAVE
OUR MEETING DATES ON TUESDAY AND
WEDNESDAY AND THIS NEXT ONE WILL
BE WEDNESDAY AND THURSDAY.
PLEASE MARK THE CALENDARS.
THE 2023 MEETING DATES ARE ALSO
AND SEPTEMBER COUNCIL IS
SEPTEMBER 19th AND 20th.
ALL RIGHT.
NEXT ON OUR AGENDA IS
CONSIDERATION OF THE NATIONAL
ADVISORY COUNCIL ON AGING.
JANUARY COUNCIL 2022 WITH THE
MINUTES OF THAT COUNCIL AND SO
IF I CAN HAVE A MOTION TO
APPROVE THE MINUTES FROM OUR
LAST COUNCIL BY OUR NA CA
MEMBERS.
>> SO MOVED.
>> SECOND.
>> ALL IN FAVOR.
>> AYE.
>> ANY OPPOSED?
NOT HEARING.
THANK YOU VERY MUCH.
WE HAVE APPROVAL OF OUR MINUTES
FROM OUR JANUARY 2022 COUNCIL.
NEXT UP WILL BE -- I'LL TURN IT
OVER TO PATRICIA JONES TO
INTRODUCE THE CHAIRS OF OUR TASK
FORCE ON MINORITY AGING
RESEARCH.
>> GOOD MORNING.
ONE SECOND, PLEASE.
I AM VERY, VERY PLEASED TO
ANNOUNCE Dr. MANLY AND Dr.
WHITFIELD THEY'LL SHARE WITH YOU
THEIR REPORT HIGHLIGHTING A
ROBUST CONVERSATION HAD
YESTERDAY ON BOTH TWO
PRESENTATIONS DELIVERED BY Dr.
JACLYN TORRES FROM THE
UNIVERSITY OF SAN FRANCISCO AND
JANUARY HE WILJANELLE BANKS.
Dr. MANLY AND WHITFIELD --
>> THANK YOU, Dr. JONES.
SO, OUR FIRST PRESENTER WAS
JACLYN OR JACKIE TOREZ FROM UCSF
WHO PRESENTED ON NUANCED
PERSPECTIVES ON SOCIAL AND INTER
GENERATIONAL RELATIONSHIPS AND
AGING IN THE CONTEXT OF
INTERNATIONAL MIGRATION SHE
STARTED OUT HER PRESENTATION
REMINDING US ABOUT THE STUDIES
SHOWING THE VITAL CONNECTIONS
BETWEEN SOCIAL RELATIONSHIPS AND
IN THE FACE OF A GROWING
POPULATION OF OLDER ADULTS NOT
BORN IN THE U.S. OR IMMIGRANTS,
SHE TALKED ABOUT THE COMPLEX AND
NUANCED SOCIAL RELATIONSHIPS
AMONG THOSE GROUPS SO I'M JUST
GOING TO TAKE A COUPLE MINUTES
TO DESCRIBE HER PRESENTATION.
Dr. TOREZ REMINDED US THAT 40%
OF LATIN AMERICAN IMMIGRANTS
MADE WEEKLY CALLS TO FAMILY AND
FRIENDS IN THEIR COUNTRIES OF
ORIGIN AND 52% SENT REMITTANCES
OR MONEY OVERSEAS OR IN OTHER
COUNTRIES.
60% OF ASIAN IMMIGRANTS AND 50%
OF LATIN AMERICAN IMMIGRANTS
REPORTED CROSS-BORDER CONTACT
AND 70% REPORTED RETURN VISITS.
SO, SHE TALKED ABOUT THE
EMOTIONAL SUPPORT THAT'S
PROVIDED BY CROSS-BORDER
CONTACT.
CROSS-BORDER SEPARATION AS A CON
INFRASTRUCTURE THAT IS IMPORTANT
IN THIS WORK AND CROSS BORDER
CAREGIVING, REMITTANCE AND
SOURCES MOST IMPORTANTLY,
SOURCES OF HETEROGENEITY AND
DOCUMENTATION STATUS, AGE, LOCAL
EXPERIENCES LIKE DISCRIMINATION
AND STRESS RELATED TO LEGAL
STATUS AND HISTORICAL AND
POLITICAL CONTEXT AND SO Dr.
TOREZ WORKED WITH TWO NIA FUNDED
STUDIES TO LEARN MORE ABOUT
THESE LINKS FIRST IN SACRAMENTO
AREA AND STUDY OF LATINOS AND
AGEING AND SHE FOUND A
SIGNIFICANT ASSOCIATION BETWEEN
MEASURES OF CROSS BORDER TIES AT
BASELINE AND SUBSEQUENT
DEPRESSION AMONG WOMEN BUT THE
DIRECTION OF THE SEWIZATION
VARIED BY ACTIVITY.
IT WAS PROTECTIVE FOR U.S.-BORN
AS WELL A RISWOMEN AND A RISK FACT TO BE F OR
LATIN BORN WOMEN.
ASSOCIATION BETWEEN CROSS-BORDER
TRAVEL AND LOWER ODDS OF
DEPRESSION FOR MEN WITH NO
VARIATION.
SO YOU CAN SEE HOW COMPLEX THIS
KIND OF WORK IS.
SHE USED THE MEXICAN HEALTH AND
AGING STUDY AND ANOTHER NIA
FUNDED STUDY TO EVALUATE CROSS
BORDER CONTACT AND FOUN AND FOUND HAVING
AN ADULT CHILD IN THE UNITED
STATES AMONG MEXICAN PEOPLE,
OLDER ADULTS IN THE U.S. OR
ADULTS WHO LIVE IN MEXICO WAS
ASSOCIATED WITH STEEPER DECLINE
IN VERBAL MEMBER ROW FOR WOMEN
AND IN AGE STRATIFIED ANALYSIS,
FOUND THE DIFFERENCES IN DELAYED
VERBAL MEMORY WAS CONCENTRATED
AMONG WOMEN 50 TO 60 YEARS SCOLD
THAT THOLD.HER FUTURE WORK WILL LOOK AT
THESE COMPLEX RELATIONSHIPS AND
INCLUDING HOW IMMIGRATION
POLICIES MAY EXACERBATE THE
LENGTH OF SEPARATION OR
FACILITATE CROSS-BORDER MOVEMENT
AND SHE TALKED ABOUT THE
COVID-19 PANDEMIC REALLY
CHANGING THE WAY THAT PEOPLE
INTERACT WITH EACH OTHER AND
FUTURE WORK NEEDS TO TAKE INTO
ACCOUNT NEW TECHNOLOGIES AND
CHANGES IN USE OF SOCIAL MEDIA
AND SMARTPHONES AND SHE ALSO
DISCUSSED FUTURE WORK IN UPWARD
OR CHILD-TO-PARENT INNER
GENERATION TRANSMISSION OF SCIO
ADVANTAGE AND DISADVANTAGE.
WE HAD A ROBUST QUESTION AND
ANSWER PER IDEA WHERE WE WERE
TREATED TO OTHER LITERATURE IN
THE TOPICS AND TALKED ABOUT
FUTURE HARMONIZATION AND GOLD
STANDARDS FOR ASKING ABOUT CROSS
BORDER TIES WHICH IS SOMETHING
THAT MORE STUDIES THAT INTEREST
NIA FUNDED SHOULD DO.
AND I'LL END THERE AND TURN IT
OVER TO Dr. WHITFIELD TO SPEAK
ABOUT OUR SECOND TALK.
>> THANK YOU, JENNIFER.
AND I'M GOING TO DO A REVIEW OF
WHAT WE WERE PRESENTED BY
JANELLE BANKS AND A SENIOR
POLICY ANNALIST FOR NIA AND SHE
ANALYZED OUR DIVERSITY
SUPPOSEMENTS AWARDED AND I THINK
AS YOU ALL KNOW, THE SUPPLEMENTS
ARE AN ADMINISTRATIVE SUPPLEMENT
THAT GOES ALONG WITH A STANDING
RESEARCH GRANT AND I THINK THERE
HAS TO BE TWO YEARS LEFT ON IT
FOR IT TO QUALIFY.
THE PROGRAM STARTED BACK IN 199 1989
AND THE DATA THIS BANK SHARED
INCLUDES 416 AWARDEES FROM THE
TIME PERIOD OF 2010 TO 2021.
AND AS A SUMMARY OF HER IN-DEPTH
ANALYSIS, ONE OF THE POINTS WAS
THERE WAS AN UPTICK OVER THAT
TIMEFRAME THAT THE MAJORITY OF
THE AWARDEES WERE FEMALE, ABOUT
69%, AND AFRICAN AMERICANS AND
HISPANICS MADE UP 82% OF THOSE.
PRE DOCUMENT DOCS AND POSTDOCS MADE UP
THE SAMPLE AT 71%.
AS YOU KNOW OF THIS PROGRAM, IT
ALSO CAN SUPPORT GRADUATE
STUDENTS AND UNDERGRADUATE
STUDENTS AS WELL AS HIGH SCHOOL
STUDENTS.
HISPANICS EDGED OUT AFRICAN
AMERICAN AT THE PRE DOCTORAL
LEVEL AND BELOW AND AFRICAN
AMERICANS OUTNUMBERED HISPANICS
AT THE POSTDOC AND FACULTY
LEVELS.
IN TERMS OF DIVISIONS, THE
DIVISION OF NEUROSCIENCE HAD THE
LARGEST PERCENTAGE OF AWARDS AT
44%.
DIVERSITY SUPPLEMENT AWARDEES
ARE 10 TIMES MORE LIKELY TO
RESEARCH HEALTH DISPARITIES
COMPARED TO NIA AWARDINGS OVER
ALL.
AND THEN JUST A COUPLE OF FINAL
POINTS ABOUT WHAT IT LOOKS LIKE,
THE PRODUCTIVITY OF THIS
PROGRAM, THE IMPACT IT HAS ON
RECIPIENTS, NIA RECEIVED AND
FUNDED SUBSEQUENT APPLICATIONS
AND WARDS BY DIVERSITY
SUPPLEMENT AWARDEES BUT HALF OF
THE DIVERSITY OF SUPPLEMENT
AWARDEES ACHIEVED FUTURE GRANT
SUCCESS AND PUBLISHED MORE ON
AGING AFTER RECEIVING A
DIVERSITY SUPPLEMENT AND AS
COMPARED TO WHAT THEY HAD BEEN
DOING BEFOREHAND AND THE LARGE
MAJORITY OF THOSE SUPPLEMENT
AWARDEES HAVE REMAINED IN
ACADEMIA AND REGRESSED INTO THE
NEXT STEPS OF THEIR ACADEMIC
CAREER.
WE ALSO HAVE A GREAT DISCUSSION
ABOUT THIS AND I THINK THE TWO
THINGS THAT WE WALK AWAY WITH
WAS ONE IS THAT WE DO NEED TO
HAVE A LITTLE BIT MORE RESEARCH
BEING ABLE TO TRACK THE SUCCESS
OF THESE FOLKS AND IN PART, I
THINK IT'S BECAUSE WE WANT TO
SEE IF THERE ARE SOME BEST
PRACTICES FOR HOW YOU ONE,
DIVERSIFY THE WORKFORCE AND ALSO
USE THESE SUPPLEMENTS TO BE ABLE
TO BE A TRAINING PIPELINE SO
THAT WE CAN INCREASE THE NUMBER
OF RESEARCHERS IN THE FIELD OF
AGING.
AND WITH THAT, I WILL STOP AND
SEE IF THERE ARE ANY QUESTIONS
AND FOLLOW-UP QUESTIONS OR
COMMENTS ABOUT EITHER ONE OF OUR
PRESENTATIONS THAT WE HEARD
YESTERDAY.
>> I WANT TO ADD, SOMETHING THAT
JUST FOR TIME THAT YOU DIDN'T
SAY ABOUT THE DIVERSITY
SUPPLEMENTS THAT WE WERE
REMINDED ABOUT YESTERDAY IS THAT
THEY'RE ONE OF THE FEW
MECHANISMS THROUGH WHICH WE CAN
SUPPORT THE WORK OF HIGH SCHOOL
STUDENTS AND THINKING ABOUT THE
PATHWAY, OR THE TRAJECTORY OF
PEOPLE INTO SCIENCE AND PEOPLE
INTO RESEARCH ON OLDER ADULTS,
HAVING A WAY TO SUPPORT WORK OF
HIGH SCHOOL STUDENTS IS
INCREDIBLY POWERFUL.
AND WE CAN DO THAT BY ENGAGING
IN THE COMMUNITY AND ALSO THE
SUPPORT THAT IS OFFERED THROUGH
DIVERSITY SUPPLEMENT FUNDING
WHICH MANY DIFFERENT KINDS OF
GRANTS ARE ELIGIBLE FOR SO JUST
WANTED TO HIGHLIGHT THAT.
>> YEAH, AND THE SLIDE YOU
SHARED WITH US, ACTUALLY IT'S
THE PRE DOCK AND BELOW, YOU
KNOW, WHEN YOU LOOK AT TWO
GROUPS IT WAS MORE HISPANICS
THAN AFRICAN AMERICANS BUT THE
LEVELS WERE LOW TO YOUR POINT.
THE CHALLENGE IS IDENTIFYING
STUDENTS AND CONNECTING THEM
WITH RESEARCHERS WHO MIGHT BE
INTERESTED IN MENTORING A HIGH
SCHOOL STUDENT OR WHATEVER.
I CAN'T REMEMBER HOW LONG IT WAS
BUT OBSSR AT ONE POINT IN TIME
HAD ALMOST LIKE A MATCH.COM
WHERE YOU COULD GO ON NATIONALLY
AND SEE IF THERE WERE LABS IN
YOUR AREA.
IT ENDED UP, AFTER NORMAN
ANDERSON LEFT,.
>> Bhinder: THAT SOME
INSTITUTIONS ACTUALLY HAVE THAT
SORT OF MECHANISM AND THAT MIGHT
BE SOMETHING TO TROY TO CONSIDER
AGAIN AT A NATIONAL LEVEL TO BE
ABLE TO HELP STUDENTS AT ALL
LEVELS OR EVEN FACULTY POSTDOCS
TO BE ABLE TO IDENTIFY THEM
BECAUSE THAT IS OFTEN TIMES ONE
OF THE CHARGES IS THAT, THE
CONNECTIONS END UP BEING ALMOST
ACCIDENTAL BUT YOU KNOW YOU TOOK
A CLASS OR YOU RUN INTO SOMEONE
AND I THINK TO YOUR POINT,
JENNIFER, THE HIGH SCHOOL
STUDENTS MAY BE THE MOST
DIFFICULT TO BE ABLE TO TIE
TOGETHER WITH THE RESEARCH
UNLESS THERE'S COORDINATED
OUTREACH.
>> PEGGY.
THANK YOU THAT'S A GREAT SUMMARY
AND I JUST WANTED TO COMMENT,
I'VE HAD GRADUATE STUDENTS ON
DIVERSITY SUPPLEMENT THIS IS THE
PAST BUT I NEVER KNEW HIGH
SCHOOL STUDENTS WERE ELIGIBLE
FOR IT SO IT'S SOMETHING WHERE
THE NIA CAN HELP GET THE WORD
OUT TO INVESTIGATORS.
WE HAVE PRETTY ROBUST PROGRAM
FOR LOCAL HIGH SCHOOLS TO COME
IN THE SUMMERS BUT I HAD NO IDEA
THAT I COULD HELP SUPPORT AND
FUND THOSE STUDENTS ON
SUPPLEMENT 0 THS ON THE NIA SO THAT'S
A INFORMATION AND COMMUNICATION
ISSUE THAT COULD IMPROVEMENT.
ON THAT NOTE, I WOULD SAY THAT
ANECDOTALLY, I WOULD SAY MANY
STUDENTS HAVE SORT OF FOUND
THEIR SPARK IN SCIENCE THROUGH A
HIGH SCHOOL EXPERIENCE AND SO
THAT IS TO THIS POINT ABOUT
REALLY GETTING PEOPLE IN EARLY
AND EXPOSING THEM TO THE
OPPORTUNITIES OUT THERE.
SO IT CAN MAKE BIG DIFFERENCE.
>> THANK YOU FOR UNDER SCORING
THAT AND I ECHO YOUR POINT WHICH
IS WHY I MADE THE ANNOUNCEMENT
YESTERDAY.
MANY INVESTIGATORS ARE NOT AWARE
THIS PARTICULAR MECHANISM CAN BE
LEVERAGED TO SUPPORT A HIGH
SCHOOL STUDENT.
THAT'S EXACTLY RIGHT.
>> JUST WANTED TO ADD ONE
PERSPECTIVE FOR OUR NEW MEMBERS
AS OUR CO-CHAIRS HAVE ELEGANTLY
DESCRIBED OUR CONVERSATION,
ASPER SPECULATIVE, MANY OF YOU
ARE AWARE THAT OUR LEADERSHIP
FOR THE AGENCY LAUNCHED THE
UNITE INITIATIVE WITH A
PARTICULAR EYE TOWARD TOWARDS RACIAL
AND ETHNIC EQUITY ACROSS THE
AGENCY AND THE EXTRAMURAL
WORKFORCE IN GENERAL.
AND IN RESPONSE, THAT EFFORT HAS
GROWN AND EXPAND APPROXIMATED TO
PROVIDE SEVERAL DIFFERENT
WONDERFUL SUGGESTIONS AND
ACTIVITIES AND RFAs THAT HAVE
BEEN POSTED ON THE COMMON FUND
AND OTHER PLACES OVER THE LAST
FEW MONTHS.
WITH RESPECT TO THIS PARTICULAR
TASK FORCE, IT WAS PARTICULARLY
TIMELY THAT OUR CO-CHAIRS WORKED
CLOSELY WITH MY OFFICE TO
IDENTIFY RESEARCHERS IN AGING
RESEARCH AND OTHER PLACE THAT'S
CAN HIGHLIGHT WORK THAT
UNDERSTAND SCORES THE IMPORTANCE
OF ADDRESSING SCIENTIFIC
WORKFORCE DIVERSITY, RACIAL
ETHNIC EQUITY, AND MINORITY
HEALTH, NOT JUST FROM AN
INDIVIDUAL LEVEL, BUT LOOKING
ACROSS DIFFERENT LEVELS OF
ANALYSIS AND INCLUDING THE
STRUCTURAL LEVEL.
AS OUR INITIATIVES ADDRESSED WE
ARE LOOKING AT STRUCTURAL
BLOWOUT LEVEL FACTORS IN AN
EFFORT TO HELP EXPAND THE
CONVERSATION AND BETTER
UNDERSTAND AT STRUCTURAL LEVEL
HOW WE MIGHT IMPROVE OUR EFFORTS
AND OUR ACTIVITIES SO I JUST
WANTED TO PROVIDE THAT
PERSPECTIVE FOR OUR NEW MEMBERS
ON THE BREADTH AND DEPTH OF
PRESENTATION THAT'S HAVE BEEN
HIGHLIGHTED OVER THE PAST FEW
COUNCILS INCLUDING YESTERDAY'S
TASK FORCE MEETING.
>> WE HAVE HANDS UP.
THANK YOU, Dr. JONES.
Dr. CRUZ AND Dr. BAKER.
>> THANK YOU, JENNIFER.
SO, YESTERDAY AFTER HEARING THE
PRESENTATION, SPECIFICALLY
THINKING OF THE R37 AWARD
PROGRAM AND I LEFT, I WAS VERY
CONCERNED, I WAS VERY CONCERNED
WITH THE NUMBER OF AFRICAN
AMERICAN AND LATINO
INVESTIGATORS THAT HAVE BEEN
FUNDED AND IN LOOKING AT HOW
COVID UNVEILED TO THE WORLD ALL
THE INEQUITY AND THE NEW
REALITIES THAT SOCIETIES ARE
FACING ACROSS THE WORLD, AND
ALSO IN THINKING THAT THIS
PROGRAM HAS BEEN IN EXISTENCE
FOR 36 YEARS, IT WAS CREATED IN
1986.
I WOULD LOVE TO RECOMMEND THAT
WE VALUE WAI EVALUATE THIS PROGRAM AND DO
A DEEPER DIVE TO UNDERSTAND ITS
PURPOSES AND FIGURE OUT CREATIVE
WAYS THAT WILL HELP US MEET THE
PURPOSE OF THE PROGRAM.
SO, I THINK THE IDEA THAT HAVE
BEEN SHARED ALREADY ARE
WONDERFUL, BUT I BELIEVE IT
WOULD BE -- THE PROGRAM MERITS
MORE TIME TO EVALUATE AND DO A
DEEPER DIVE AND THINK OF
ADDITIONAL IDEAS THAT CAN HELP
US ACCOMPLISH OUR GOALS, GIVEN
THE NEW ROW A LOT REA GIVEN REALITY AND GI VEN THE
CHANGE OF OUR POPULATION.
>> THANK YOU.
THANK YOU FOR THAT.
Dr. BAKER.
>> I JUST WANTED TO ECHO I
THOUGHT THE PRESENTATIONS
YESTERDAY WERE WONDERFUL.
IT HELPS ME TAKE A DIFFERENT
PERSPECTIVE OF THINKING ABOUT
THINGS DIFFERENTLY WHICH IS
ALWAYS GREAT.
MY QUESTION IS NOT A VERY
ELEGANT ONE BUT MORE LOGISTICAL
RELATED TO THE DIVERSITY
SUPPLEMENTS IN THE TIMING OF
WHEN I NEED TO BE APPLYING TO
TROY TO -- IF I IDENTIFY A
CANDIDATE, WHAT SORT OF
TIMEFRAME.
BECAUSE I WORRY SOMETIMES I
MISSED, PARTICULAR WINDOWS WHERE
I NEED TO HAVE IT BE APPROVED
AND ALL OF THOSE THINGS.
IT'S NOT A BEAUTIFUL QUESTION
BUT MORE JUST AS A LAB DIRECTOR,
THE LOGISTICAL BEHIND IT OF, HOW
EARLY IN THE PROCESS WOULD I
NEED TO IDENTIFY A CANDIDATE IF
THEY WERE GOING TO BE COMING IN
THE SUMMER?
WOULD IT NEED BE APPLIED FOR
THOSE TYPES OF QUESTIONS?
WHAT IS THE TURN AROUND?
>> GREAT QUESTION.
>> THANK YOU.
>> CAN YOU PROVIDE US WITH THAT
PROCESSES BECAUSE I KNOW I'VE
BEEN A PART OF IT FOR YEARS BUT
THERE'S A TIMING ISSUE AND Dr.
BAKER YOU ARE ASKING AN
EXCELLENT QUESTION.
>> EXCELLENT QI.
THANK YOU SO MUCH AND I
ENCOURAGE YOU TO REACH OUT TO
OUR TRAINING OFFICER.
I'M NOT SURE IF SHE'S ON-LINE
TODAY BUT WE CAN CERTAINLY
REVIEW IN CONCERT WITH YOUR
SPECIFIC PROGRAM AND ACTIVITIES
AND YOUR PARENT AWARD, WHAT
MIGHT BE AN IDEAL TIME TO
CONSIDER WORKING WITH YOUR
STUDENTS OR CANDIDATES THAT YOU
HOPE TO SUPPOSE SORT.
WE ALSO HAVE UPDATED OUR WEBSITE
AND THE LAST SEVERAL MONTHS THAT
MIGHT HELP ANSWER YOUR QUESTION
AND WE'RE CERTAINLY HAPPY TO
PULL DETAILS AND WORK DIRECTLY
WITH YOU TO GIVE YOU MORE
FOCUSED RESPONSE.
WE'RE SPOT ON AND YOU WANT TO BE
THOUGHTFUL AND INTENTIONAL AND
IDENTIFYING YOUR TIME LINES TO
GIVE BOTH AND YOU YOUR CANDIDATE
AND YOUR INSTITUTIONS MAXIMUM
TIME TO CRAFT OUT A MEANINGFUL
TRAINING PLAN, CAREER PLAN,
TIMELINE AND USEFUL ACTIVITIES
THAT FIT WITH WHERE THEY ARE AND
THEIR KA ROAR AND WHERE THEY
HAVE HOPE TO ASPIRE TO MOVE
TOWARDS.
>> JUST A PHOTO UP T A FOLLOW-UP, CAN YOU
SEND ME THE CONTACT INFORMATION.
DO THE CANDIDATES HAVE TO BE
DEFINED IN TERMS OF CAN I MORE
GO AS A TARGETED RECRUITMENT FOR
A TYPE OF INDIVIDUAL RELATIVE TO
A SPECIFIC INDIVIDUAL?
>> WE REALLY WANT THE PERSON WHO
BRINGS PARTICULAR EXPERTISE AND
LIVED EXPERIENCES TO BENEFIT
BEST FROM THESE RESOURCES.
WE DON'T WANT THE RESOURCES TO
BE A HOLD.
>> GOT IT.
>> THANK YOU.
>> YES.
>> AND JUST TO GIVE MY
CONSENSUS, SOMEONE WHO WAS BOTH
HAD SUPPLEMENT AND STUDENTS WHO
HAD SUPPLEMENTS, Dr. BAKER
YOUR QUESTION IS SO SPOT-ON
BECAUSE THAT IS ONE OF THE
CHALLENGES IS GETTING THROUGH
THE PROCESS WHICH I DON'T KNOW
IF IT'S STILL CURRENT BUT IT
USED TO TAKE AT LEAST SIX TO
EIGHT WEEKS BUT YOU NEED TO
IDENTIFY THAT PERSON AND MAKE
SURE THEY'RE YOUR INSTITUTION
CAN HAVE ALL OF THAT HAVE IN
LINE AND PREPARED FOR.
IF IT'S GOING TO BE, FOR
EXAMPLE, LET'S TALK ABOUT A
SUMMER STUDENT, Dr. MANLY'S
POINT ABOUT MAYBE A HIGH SCHOOL
STUDENTS IS A REALLY COOL ONE SO
IF YOU GET A HIGH SCHOOL
STUDENT, YOU SHOULD TRY TO
IDENTIFY HIM I THINK IN THE FALL
AND BEING ABLE TO PUT TOGETHER
THE APPLICATION, SPEAK WITH THE
PROGRAM OFFICER, PUT IN THE
APPLICATION, AND GET IT IN AND
VERY LATE FALL SO THAT IN THE
FIRST PART OF THE SPRING, YOU
WILL KNOW ABOUT IT AND CAN GET
ALL OF THAT SET UP AND YOU ARE
READY TO GO WITHOUT ANY KIND OF
INTERRUPTION AND JUST FOR
PLANNING SO IT'S ONE OF THOSE
THINGS WHERE I THINK OFTEN
TIMES, WE THINK ABOUT LATER YOU
MEET THE STUDENT AT THE END OF
THE SUMMER AND IT'S TO LATE
BECAUSE OF THE PROCESS, BOTH
INTERNALLY AS WELL AS FOR NIA
AND EXTERNALLY IN TERMS OF YOUR
INSTITUTION.
>> Dr. MANLY, IF I COULD ADD
THE SUPPLEMENT RECEIPT IS EVERY
MONTH UNTIL THE MONTH OF JUNE
AND THEN IT BEGINS BACK AGAIN ON
OCTOBER 1st AND EVERY 30 DAYS
WE RECEIVE APPLICATIONS.
>> SO NO DIVERSITY SUPPLEMENTS
ARE REVIEWED BETWEEN JULY AND
AUGUST AND SEPTEMBER.
IS THAT RIGHT?
>> YES.
CORRECT.
THERE'S A THREE-MONTH COOLING
OFF PERIOD BECAUSE THE BUDGET IS
ENDING AND WE NEED TO MAKE SURE
WE MEET OUR BUDGETARY TIME FOR
REVIEWING THEM AND MAKING THEM
WHETHER THEY'RE MERITORIOUS
ENOUGH TO BE FUNDED.
>> MAN, YOU LEARN SOMETHING
EVERYDAY.
I HAD NO IDEA OF THAT
THREE-MONTH COOLING OFF PERIOD.
YEAH, SO THE TIMING IS
IMPORTANT.
AND THE SIX TO EIGHT WEEKS THAT
Dr. WHITFIELD WAS TALKING FROM
IS FROM SUBMISSION UNTIL YOU GET
WORD OF WHAT IS GOING TO HAPPEN
AND JUST A REMINDER OF THE LIFE
OF THE GRANT MATTERS HERE TOO.
THAT YOU KNOW, DIVERSITY
SUPPLEMENTS NEED TO BE SITUATED
WITHIN A PARENT GRANT AND THAT
GRANT'S FUNDING PERIOD MATTERS
FOR THIS SO IT'S JUST SOMETHING
TO CONSIDER AS WELL.
>> I JUST WANTED SAY I KNOW THIS
IS ALL AVAILABLE ON THE WEBSITE
BUT GIVEN THAT WE'RE NOT QUITE
CLEAR ON ALL OF THIS, IT SEEMS
LIKE WE COULD DOUBLE DOWN ON
TRYING TO GET IT AND THINKING
BIN OWE HAVE A TIVE WAYS TO GET
THE WORD OUT SO MORE PEOPLE KNOW
ABOUT WHAT IT WOULD TAKE AND
MAYBE A LITTLE HAND-HOLDING
ABOUT HOW TO MAKE IT HAPPEN.
>> YEAH.
I WAS THINKING, YOU KNOW, ONE OF
THE THINGS WE DISCUSSED WAS WHEN
YOU GET A GRANT, FIRST, YOU NEED
TO KNOW WHETHER IT IS A GRANT
THAT IS ELIGIBLE FOR DIVERSITY
SUPPLEMENT OF MANY OF THEM ARE.
WHEN YOU KNOW THAT, MAYBE
THERE'S A WAY FOR GRANTEES, WE
HAVE THIS AS I MAZING TOOL, FOR
US TO CONNECT PEOPLE WHO ARE
OPEN AND WILLING TO CONSIDER
DIVERSITY SUPPLEMENTS WITH
PEOPLE WHO HAVE GRANTS THAT ARE
FUNDED THAT ARE ELIGIBLE AND
PART THAT HAVE IS A MINDFUL OR
ACTIVITY BY THE PI WHICH IS
EXACTLY WHAT Dr. CASE WAS
TALKING ABOUT SORT OF US GETTING
THE WORD OUT BUT ALSO SOME
COMMUNICATION WITH THE PIs
ABOUT HOW THAT WOULD WORK AND
SOME ACKNOWLEDGMENT THERE THAT
CAN BE MAYBE ROOT NICED FOR ALL
OF THE RECIPIENTS OF THESE TYPES
OF GRANTS.
>> AS A PARENT OF HIGH
SCHOOLERS, THERE'S NO WAY YOU
COULD IDENTIFY THOSE CANDIDATES
IN THE FALL FOR THE FOLLOWING
SUMMER.
AT LEAST YOU ARE LUCKY IF YOU
HAVE GOT APPLICANTS IN MARCH
BECAUSE THAT'S WHEN THEY START
THINKING ABOUT WHAT THEY'RE
DOING FOR THE SUMMER.
IF YOU HAVE TO PUT AN
APPLICATION THAT IS GOING TO
TAKE TWO MONTHS TO GET REVIEWED,
AND THEY'RE GOING TO WONDER THEY
HAVE A DIFFERENT SUMMER JOB IN
THE MEANTIME THEY'RE GOING TO GO
SOMEWHERE ELSE.
I THINK GIVEN THE COST OF THE
HIGH SCHOOLERS TO SUPPORT
MUSTING MINUSCULE COMPARED TO
ALL THE OTHER COSTS.
IT SEEMS THERE OUGHT TO BE A WAY
TO STREAMLINE THAT AND MOVE THE
NEEDLE.
I WOULD LOVE TO SEE THAT CHANGE.
LOGIC TICKS WOULD HAVE TO
CHANGE.
>> I GROW 100% AND THE WAY THAT
IT SORT OF MANIFESTED AT MY OWN
INSTITUTION IS MY INSTITUTION
HAS PROGRAMS WITH COMMUNITY HIGH
SCHOOLS.
WE'RE ASKED WHETHER WE'RE
INTERESTED IN MENTORING THEM AND
THAT'S ONE WAY OF -- THE SLOT IS
OPEN AND FOR THE HIGH SCHOOLS'
SCHEDULE AND IF THOSE STUDENTS
WOULD LIKE TO CONTINUE WITH US
AND MANY OF THEM WERE EXCITED TO
DO THAT BECAUSE OVER THE SUMMER
THEY WERE AMAZINGING AND REALLY
INTERESTED IN THE WORK AND WANT
THE TO FINISH A PROJECT AND WE
INITIATED WORK WITH US IN THEIR
SENIOR YEAR OR UNION YEAR OR
WHATEVER IT IS AND SO WE'LL KNOW
THEM OVER THE SUM ARE WE'RE
PLANNING FOR A YEAR-LONG TYPE OF
RESEARCH PROJECTOR AT THAT POINT
AFTER THE SUMMER IS OVER, WE'RE
PLANNING FOR THE NEXT SUMMER.
SO I LIKE THAT AND I LIKE HOW WE
CAN INTERSECT WITH ALREADY
FUNDED MECHANISMS THROUGH
INSTITUTIONS.
>> IN PART, WHAT WE'RE TALKING
ABOUT HERE AND IT WAS HAVING
EXISTING CONNECTIONS WITH HIGH
SCHOOLS IS PROBABLY CRITICAL.
BECAUSE YOU ARE NOT GOING TO GET
NO THE FLOW OF THE ACADEMIC YEAR
FOR THOSE STUDENTS AND IDENTIFY
THEM UNLESS YOU HAVE SOMETHING
THAT'S EXISTING SO THAT'S A
GREAT SUGGESTION FOR A POSSIBLE
CONCEPT IS SOMETHING THAT
SUPPORTS CONNECTION S WITH HIGH
SCHOOLS TO LEAD THEM NO THAT
PROGRAM AND THE OTHER PIECE,
THERE WAS ANOTHER PIECE ABOUT
THE TIMING AND PROGRAMS HERE
THAT WORKS ON THIS, IT'S YOU ARE
SUPPOSED TO HAVE TWO YEARS LEFT
ON YOUR GRANT.
SO IF YOU HAVE A FIVE-YEAR
GRANT, THERE'S THREE YEARS YOU
CAN OUT THERE RECRUITING
STUDENTS BUT THERE NEEDS TO BE
TWO YEARS LEFT ON THE GRANT.
THAT MAY HAVE BEEN BECAUSE YOU
WANT TIME FOR THE PERSON TO GET
IN AND GET STARTED AND FINISH
THE WORK BEFORE YOUR GRANT ENDS.
THERE USED TO BE A TWO-YEAR
LIMIT ON THAT AND ONE LAST
THING, CONVERSATION WENT SO
QUICKLY I HAD A COUPLE OF
COMMENTS.
HIGH SCHOOL STUDENTS ARE FAR
CHEAPER.
UNDERGRADUATES ARE A LITTLE MORE
EXPENSIVE.
GRADUATE STUDENTS ARE MORE
DIFFICULT AND YOU NEED TO THINK
ABOUT THE FUNDING THEY HAVE IF
THEY'RE ON A T32 AND DOES THIS
INTERRUPT OR CONFLICT WITH THAT
AND POSTDOCS AND FACULTY BECOME
MUCH MORE DIFFICULT TO DEAL WITH
SO IF YOU ARE THINKING ABOUT
INCLUDING SOMEONE AT THAT LEVEL,
YOU NODE TO MAKE SURE YOU CAN
MAKE GREAT JUSTIFICATIONS FOR
HOW TO PAY THEM.
THAT ENDS UP BEING THE
DIFFICULTY IN TERMS OF
LOGISTICS.
>> THANK YOU.
I WAS WONDERING ABOUT THE NIA
STAFF AND WHAT IS OUR
INTENTIONALITY ABOUT MAKING SURE
INVESTIGATORS ARE TAPPED ON THE
HOSHOULDER TO DO THIS IS WHAT I'M
SAYING.
THE PROGRAM STAFF PROBABLY HAVE
SOME SORT OF APPROACH THAT
THEY -- I'M HOPING THEY TAKE
METICULOUSLY.
SAYING YOU ARE ARE ELIGIBLE AND
HOW CAN I HELP YOU?
I'M JUST INTERESTED IN THAT.
>> I'LL TURN TO MY COLLEAGUES IN
PROGRAM WHO CAN DESCRIBE SOME OF
THEIR OUTREACH ACTIVITIES BUT
I'LL JUST SAY MORE BROADLY, WE
LEVERAGE ALL OF THE INSTITUTES'
COMMUNICATION PLATFORMS AND
HIGHLIGHTING THROUGH OUR NEWS
LETTERS AND IT HAS A VERY
EFFECTIVE BROAD REACH, I CAN
SPEAK FROM PERSONAL EXPERIENCE
WHEN I'VE WRITTEN BLOGS, THEY'VE
HELPED GET THE WORD OUT QUICKLY
AND PEOPLE PAY ATTENTION.
TO SHARE THE WORD THAT WE HAVE
THIS RE SOURCE AVAILABLE AND
I'LL JUST SAY THAT WE'RE ALSO
PLANNING TO CONVENE A DIVERSITY
SUPPLEMENT WORKSHOP LATER THIS
SUMMER AND WE'RE WORKING ON THE
REGISTRATION NOW AND THE WHOLE
POINT IS TO ENGAGE AWARDEES,
LEVERAGE AND LEARN MORE ABOUT
THE TYPES OF SCIENTIFIC
ACTIVITIES THAT THEY'VE BEEN
ENGAGING WITH RESOURCE AND IT
ALSO LEVERAGE WORD-OF-MOUTH
BECAUSE WE KNOW THEY WILL SHARE
THEIR EXPERIENCE AND THEIR PLANS
TO PRESENT WITH THEIR PEERS AND
THEIR MENTORS AND MAKING THEM
AWARE THAT THIS IS AN ONGOING
PLACE OF INTEREST BUT I'LL SHIFT
NOW TO MY COLLEAGUES IN PROGRAM
AND I SEE Dr. NEILSON HAS COME
ON CAMERA.
WOULD YOU LIKE TO SPEAK TO THE
EFFORTS OR OUTREACH?
>> YEAH.
I WOULD SAY THAT WE HAVE AN
APPROACH AND I CAN'T SAY FOR
SURE THAT EVERYONE DOES THIS
CONSISTENTLY BUT WHEN PEOPLE
RECEIVE A NEW AWARD WE REMIND
THEM OF SEVERAL THINGS INCLUDING
LETTING US KNOW ABOUT SCIENTIFIC
ADVANCE AND THIS DIVERSITY
SUPPLEMENT PROGRAMS EXISTS AND I
FEEL STRONGLY ENCOURAGED TO GET
THAT MESSAGE OUT MORE REGULARLY
AND ENSURE THAT FOLKS ARE DOING
AND WE ALSO HAVE A NEWSLETTER
THAT GOES OUT TO OUR GRANTEE AND
TWITTER COUNT WHERE WE REACH
DIFFERENT AUDIENCE AND I THINK
THERE'S AN AUDIENCE THERE IN THE
POTENTIAL DIVERSITY CANDIDATES
WHO MIGHT BE LOOKING FOR THESE
OPPORTUNITIES AND THEY MAY
CONNECT WITH US ON TWITTER.
WE DO PUT MESSAGES OUT THERE
ABOUT THESE PROGRAMS BUT
REMEMBERING IT'S A REGULAR
THROUGH OUT YEAR PROGRAM,
REGULAR REMINDERS WOULD BE
USEFUL BOTH FOR PEOPLE WITH THE
GRANTS AS WELL AS PEOPLE WHO
MIGHT BE LOOKING FOR THESE
OPPORTUNITIES SO I APPRECIATE
THE ATTENTION TO THIS AND WE'LL
BE CAREFULLY MONITORING TO MAKE
SURE THAT WE'RE GETTING THE WORD
OUT ON ALL THESE CHANNELS.
>> IT SEEMS LIKE A PROCEDURAL
MECHANISM BECAUSE EVERYBODY IS
BUSY AND PEOPLE READ BADLY AND
IT SOUNDS TO ME LIKE THAT WOULD
BE HELPFUL SO THANK YOU FOR
SAYING THAT.
>> SO WE HAVE TO MOVE ON
UNFORTUNATELY, I GOT A VERY NICE
NOTE FROM KEN IN MY CHAT.
I KNOW THAT THEY HAVE THAN HANDS
BUT UP, WE HAVE TO GO AND MAYBE
WE CAN CONTINUE OUR CONVERSATION
IN THE CHAT.
>> I DID ADD A NOTE OF USING
DIFFERENT PHASES AT MORE THAN
ONE TIME TO SUPPORT DIVERSE
DOLLARS.
>> THANK YOU VERY MUCH,
EVERYONE, FOR ALL THE FEEDBACK.
IT'S VERY IMPORTANT PROGRAM TO
OUR INSTITUTE AND WE WILL
CERTAINLY TAKE ALL OF OF THESE
SUGGESTIONS BACK AND HOPEFULLY
IMPROVE OUR COMMUNICATIONS TO
THE COMMUNITY AND FURTHER OUR
OUTREACH OVER ALL.
SO, MOVING THEN ON, OUR NEXT WE
HAVE OUR HIGHLIGHTS FOR OUR
WORKING GROUP ON PROGRAM.
I'LL TURN IT OVER NEXT TO MONICA
DRISCOLL, OUR CHAIR.
>> ALL RIGHT.
THANK YOU.
SO, WE HAD GREAT CONVERSATION ON
10 CONCEPTS IN CONTRACTS THAT
WERE PUT FORWARD BY PROGRAM AND
I'M HAPPY TO TELL YOU THAT THERE
WAS ENTHUSIASM FOR ALL CONCEPTS
MOVING FORWARD SO WHAT WE'RE
GOING TO DO NOW IS RUN THROUGH
SUMMARY BY THE PRIMARY REVIEWERS
FOR THE PARTICULAR CONCEPTS AND
THE FIRST ONE ACTUALLY IS -- A
CONCEPT THAT I REVIEWED.
SO THIS IS FOR A PUT FOURTH BY
THE DIVISION OF AGING BIOLOGY
FOR GEROSCIENCE COURSE.
THIS WAS A CONCEPT THAT WAS PUT
TOGETHER REALLY BY THE GER
OLYMPIOSCIENCE GROUP WHICH PROPOSED R25
MECHANISM TO ENHANCE RESEARCHER,
AWARENESS OF OF THE ENTA GREAT
TIVE PRINCIPLES IN GEROSCIENCE
AND KIND OF TO PROMOTE A MORE
COHERENT CONVERSATION OF OF OF
THIS AS AN ANCHOR ACROSS ALL
ASPECTS SO YOU KNOW IT'S BECOME
CLEAR THAT THIS IDEA OF
GEROSCIENCE THAT AGING IS THE
MAJOR KIND OF RISK FACTOR FOR
ALL THE DISEASES THAT WE'RE
STILL TRYING TO CONQUER FOR
OLDER AGE AS WELL AS THE
CONVERSE IDEA THAT AN ENCOUNTER
WITH THE DISEASE COMPROMISES THE
AGING PROCESS AND THAT THERE
NEEDS TO BE THIS INTEGRATIVE
UNDERSTANDING OF BOTH BIOLOGY
AND HOW THIS I AM PACK IMPACTS EVERYTHING
WE DO.
THERE WAS A 2019 SUMMIT MEETING
ON GEROSCIENCE AND ONE OF THE
RECOMMENDATIONS THAT CAME OUT OF
THAT MEETING WAS THAT THERE
NEEDS TO BE AN INCREASED
AWARENESS OF GEROSCIENCE
RESEARCH ADVANCES AND THE FOCUS.
AND SO THIS R25 SEEKS TO
ACCOMPLISH THAT BY PROVIDING
FUNDING FOR SERIES ON-LINE
COURSES, SUMMER INSTITUTES, AND
ANY CREATIVE INTERACTIONS THAT
COME FORWARD.
AND IMPORTANT COMPONENT OF THIS
IS THAT THE PROPOSED PROGRAMS
WOULD BE EXPECTED TO ADDRESS HOW
THE APPROACHES OF GER OLYMPIC
SCIENCE CAN ALSO INFORM ON
HEALING DISPARITIES AND AGING SO
IT'S LIKE A DEFINITE PLUS.
SO, THERE WAS A GOOD DISCUSSION.
THE CO REVIEWER WAS Dr.
WHITFIELD WHO MADE IMPORTANT
POINTS THAT THERE MIGHT BE SOME
INCREASED SPECIFICATION OF HOW
THE R25 EFFORT MIGHT HELP
INCREASE DIVERSITY IN THE
SCIENCE WORKFORCE AND THERE MAY
BE INSTRUCTIONAL DESIGNER TO
KIND OF PLAN THE CONTENT
CREATION AND SOME COORDINATION
AMONG THE LEARNING OBJECTIVE AND
ARTICULATION OF LEARNING
OBJECTIVES AND MIGHT HELP
COORDINATE THE OVER ALL EFFORTS.
BASICALLY, THIS MECHANISM WOULD
BE INVOLVING A PROGRAM
ANNOUNCEMENT SPECIFIC, SPECIAL
RECEIPT, REFERRAL AND THE BROAD
AGING-TYPE RESEARCH THAT WOULD
BE INVOLVED AND THERE'S BEEN A
LOT OF THOUGHT IN THIS CLEARLY
SUPPORTS THE STRATEGIC
OBJECTIVES OF THE NIA AND GOING
FORWARD SO THERE WAS A LOT OF
ENTHUSIASM FOR MOVING THIS R-25
PROPOSAL FORWARD.
SO, THE NEXT PROPOSAL IS
ENTITLED ESTIMATING THE MONETARY
COSTS OF DEMENTIA IN THE UNITED
STATES USING NIA-FUNDED
DATASETS.
THE PRIMARY REVIEWER WAS Dr.
CASE, WOULD YOU LIKE TO
SUMMARIZE THE CONTENT OF OUR
DISCUSSION?
>> SO, THERE WAS REAL ENTHUSIASM
FOR THIS CONCEPT CLEARANCE AND
TO HAVE AN.
>> TAPPING INTO ALL DATA AGO
SETS AND THE ENCLAVE IN ORDER TO
CREATE SUCH AN ESTIMATE SEEMS
LIKE A WORTHY IDEA.
I THINK THAT OUR COMMENTS WERE
HOW TO MAKE THE RFA MORE PRECISE
AND THE VERY IMPORTANT ROLE OF
FAMILIES AND PATIENTS LIVING
WITH DEMENTIA AND THE ROLE THEY
WILL PLAY IN THIS GOING FORWARD.
MORE SPECIFICITY ON WHICH CAUSES
WHICH BE INCLUDED AND NOTING
THAT MANY OF THE COSTS THAT ARE
IMPORTANT TO FAMILIES ARE NOT
COVERED IN DATA AND I THINK WITH
MORE PRECISION IN THE RFA, THIS
WOULD BE AN EXCELLENT CANDIDATE
TO GO FORWARD.
>> THANK YOU, VERY MUCH, FOR
THAT WONDERFUL SUMMARY.
THE NEXT CONCEPT WAS FROM THE
DIVISION OF NEUROSCIENCE AND A
RE-ISSUE OF ENTA GRAY TIVE
RESEARCH TO UNDERSTAND THE
IMPACT OF SEX DIFFERENCES AND ON
THE MOL BEING YOU LAR
DETERMINANTS OF AD RISK AND
RESPONSIVENESS TO TREATMENT.
WOULD YOU LIKE TO TALK ABOUT THE
DISCUSSION.
>> THIS IS A CONCEPT THAT
PROPOSES TO ISSUE FOR THE THIRD
TIME A FUNDING ANNOUNCEMENT THAT
IT WAS INITIALLY ISSUED IN 2017
AND THEN REISSUED IN 2021.
AND THE GOAL HERE IS TO HAVE AN
RFA FOR UNDERSTANDING THE IMPACT
OF SEX DIFFERENCES ON THE
TRAJECTORIES OF BRAIN AGING,
ALZHEIMER'S AND RELATED
DISORDERS, PHENOTYPES OF RISK
AND THEN RESPONSIVENESS TO
TREATMENT AND IT'S GOING TO
INCLUDE STUDIES THAT EXPLORE HOW
GENES AND ENVIRONMENT AND HOR
HORMONAL STATUS INTERACT FROM
CELLS, TISSUE, ORGANS, ORGAN
SYSTEMS AND POPULATIONS AND TO
PRODUCE HETERO GENIE US TYPES OF
RISK AND THIS IS A VERY HIGHLY
SUCCESSFUL INITIATIVE AND SINCE
IT WAS FIRST ISSUED AND SEVERAL
RO1s FUNDED MULTIPLE
PUBLICATIONS AND I THOUGHT THE
IDEA OF FOCUSING NOW ON
HETEROGENEITY AND THE MULTI
FACTORIAL NATURE OF ALZHEIMER'S
AND OTHER DIMENSION IS REALLY
IMPORTANT RIGHT NOW AND
ESPECIALLY AS WE'RE ALL MOVING
TOWARDS PRECISION MEDICINE
APPROACHES AND DEVELOPMENT OF
EFFECTIVE INTERVENTIONS FOR
PREVENTING OR DELAYING THE ONSET
OF DISEASE, IT WILL BE A
CO-OPERATIVE AGREEMENT MECHANISM
WHICH IS ALSO VERY REASONABLE
BECAUSE THAT WILL ALLOW PROGRAM
TO HAVE MORE INPUT INTO IT AND
MAKE SURE THERE'S DATA SHARING
AND THAT THERE ARE POTENTIAL
INTERACTION S WITH SOME OF THE
OTHER NIA CONSORTIUM LIKE MODEL
AD SO EVERYONE WAS VERY HIGHLY
SUPPORTIVE OF THIS CONCEPT.
>> GREAT.
THANK YOU, VERY MUCH.
THE NEXT CONCEPT COMES FROM THE
DIVISION OF AGING BIOLOGY,
DEVELOPMENT MAINTENANCE AND RAT
COL GEE Dr. PETERSON WAS THE
PRIMARY REVIEWER.
>> THIS IS A PROPOSAL TO FUND
THE FINAL YEARS OF A 10-YEAR
CONTRACT TO MAINTAIN A AGED RAT
COLONY AND THIS NIA AND DAB
THAT'S BEEN AVAILABLE FOR A
COUPLE OF DECADES PROVIDING AGED
RATS TO INVESTIGATORS ALL OVER
THE COUNTRY AND ALL OVER THE
WORLD, ACTUALLY.
THE CONTRACT OF THIS ROUND IS A
10-YEAR CONTRACT WHICH BEGAN IN
2016 AND IT'S BEEN VERY
SUCCESSFUL AND THEY'VE REACHED
THEIR GOALS AND THEY HAVE VERY
STABLE GENERATED RATS AND
PROVIDED THEM TO INVESTIGATORS
FOR THE FIRST SIX YEARS OF THE
CONTRACT AND SO THIS REQUEST IS
TO NOW FUND THE FINAL FOUR YEARS
OF THE CONTRACT, IN WHICH THEY
GENERATE, THEY GROW BOTH THE
FISHER 344 GRANT, THE BROWN RAT
AND THE TWO-WAY CROSS FISHER
BROWN AND AGED AND PROVIDE THEM
TO INVESTIGATE AND SO IT WAS A
VALUABLE RESEARCH FOR
EXPERIMENTAL CONTINUITY AND IT
IS SOMETHING THAT IS VERY WIDELY
USED AND VERY VALUABLE TO THE
AGING RESEARCH COMMUNITY SO
THERE WAS STRONG ENTHUSIASM TO
FUND THIS.
>> GREAT.
THANK YOU, VERY MUCH.
THE NEXT CONCEPT IS A DIVISION
OF AGING BIOLOGY DEVELOPMENT AND
TO MAINTENANCE OF A NON HUMAN
PRIME AT TISSUE BANK.
Dr. HUANG WAS THE PRIMARY
REVIEWER.
>> THERE WAS A GOOD DISCUSSION
ABOUT THIS RENEWED CONTRACT TO
PRIMARY CENTER SO THIS IS ABOUT
NON-HUMAN PRIMATE TISSUE BAND.
THIS IS A CENTRALIZED BAND FOR
TEAM OF DIFFERENT ORGAN TISSUES
AND SAMPLES SPANNING OLD AGE,
YOUNG AGE, SOME NON HUMAN
PRIMATES TO IT WAS INITIATED AND
IT HAS BEEN ALMOST 20 YEARS ON
GOING AND THE CURRENT BAND HOLDS
MORE THAN 380 KIDS AND 18
PLACENTA AND EACH HAS TISSUE
FROM ONE ANIMAL SO THAT WOULD BE
USEFUL FOR THE NEEDS OF MANY
INVESTIGATORS.
SO THE NEW CONTRACT RENEWAL WILL
MAINTAIN AND MANAGE A COLLECTION
OF TISSUE AND DERIVATIVE FROM
NON HUMAN PRIMARY INITIATIVES TO
EXPAND THIS SCOPE.
SO, THERE WAS A GOOD DISCUSSION
ABOUT THIS AND THERE WERE
DISCUSSIONS RECOMMENDATIONS FROM
THE COUNCIL TO INCREASE THE
AWARENESS OF THIS TISSUE BANK,
POTENTIAL WAYS OF CODIFY AND
MANAGING THE PRODUCTIVITY OF THE
TUSH EUBANK AND HOW LINK THIS TO
ANOTHER AND MOVING
THIS CONTRACT FORWARD.
THANK YOU.
>> THANK YOU, VERY MUCH.
DON'T GO AWAY.
SO, YOU ARE PRIMARY REVIEW ERR
ON THE NEXT APPLICATION OR THE
NEXT CONCEPT WHICH IS FROM THE
DIVISION OF AGING BIOLOGY ON THE
MANAGEMENT OF THE PRIMATE AGING
DATABASE.
>> YEAH, SO THIS IS VERY RELATED
CONTRACT IT'S CALLED TIMELY
AGING DATABASE AND THIS DATABASE
IS A RESOURCE FOR INVESTIGATORS
IN THE FIELD OF AGING RESEARCH
AND DESIGNED SO FACILITATE THE
USE OF NON HUMAN PRIMATES AND
IT'S FOR THE DATABASE AND THIS
DATABASE CAN MEASURE TISSUE BANK
HAS ALSO OVER 20 YEARS AND IT
CONTINUES TO BE HIGHLY RESOURCE
AND WIDELY USED IN THE AGING
RESEARCH FIELD AND THE DATABASE
COLLECTED DATA FOR THE NON-AGING
AND YOUNG HUMAN PRIMATES AND ALL
IN ONE AND THERE ARE CHEMISTRY
MEASUREMENTS AND COMPLETE BLAST
CELL COUNTS AND BODY WEIGHT AND
PRESSURE AND MANY OTHER PRIMARY
THERE AND DATA ALSO USED BY THE
RESEARCH COMMUNITY TO IDENTIFY
CHANGE IN BIOLOGICAL AGING AND
ALSO TO VALIDATE THIS THE RUM AN
AGEING AND PERFORM COMPARATIVE
ANALYSIS IN THE FIELD AND LIKE I
SAID IT'S BEEN WIDELY HUGE FOR
OVER 20 YEARS AND THE OBJECTIVE
OF THIS CONTRACT RENEWAL IS TO
CONTINUE TO SUPPORT OUR
LONGSTANDING NIAD DATABASE AND
EXPANDING THEIR USAGE.
THERE'S GOOD DISCUSSION AND
RECOMMENDATIONS FROM THE COUNCIL
TO ALSO INCREASE THE AWARENESS
OF THE DATABASE AND QUANTIFYING
AND MANAGING THE PRODUCTIVITY OF
THIS DATABASE AND LINK TO THE
ONE WE JUST TALKED ABOUT, NON
HUMAN PRIME AT TISSUE BANK HOW
TO CONNECT THEM IN THE FUTURE SO
IN GENERAL, THERE WAS A STRONG
SUPPORT ACROSS THE BOARD FROM
THE COUNCIL TO MOVE THIS
CONTRACT MOVING FORWARD.
THANK YOU.
>> THANK YOU.
>> SO, THE NEXT WAS THE MEX-AD,
CLINICAL EPIDEMIOLOGICAL AND
GENETIC CHARACTERIZATION OF
ALZHEIMER'S PATIENTS IN THE
ADMIXED MEXICAN POPULATION.
Dr. MANLY WAS THE PRIMARY
REVIEWER.
>> THIS IS TO SUPPORT A CONTRACT
THAT WOULD ESTABLISH A COHORT OF
1,000 PEOPLE WHO WERE LIVING
WITH ALZHEIMER'S DISEASE AND
1,000 PEOPLE WHO ARE NOT
NEUROLOGICALLY HEALTHY OF THE
SAME AGE AND BACKGROUND FROM 10
CLINICAL SITES IN MEXICO AND
THESE PARTICIPANTS WOULD BE
RECRUITED THROUGH A COLLAB
RATION BETWEEN CARD, WHICH IS
THE CENTER FOR ALZHEIMER'S
DISEASE AND RELATED DIMENSION
THAT Dr. HODES REMINDED US, TO
AND UPDATED US ON EARLIER THIS
MORNING AND A CONSORTIUM CALLED
RED LAT WHICH IS A RESEARCH
CONSORTIUM FOR DEMENTIA RESEARCH
IN LATIN AMERICA THAT IS
COORDINATED OUTSIDE OF
UNIVERSITY OF CALIFORNIA SAN
FRANCISCO MEDICAL CENTER AND THE
AIMS OF THIS COLLABORATION WOULD
BE TO COLLECT GENETIC SAMPLES
AND COLLECT BLOOD FROM THESE
PARTICIPANTS TO PROSECUTE FORM
SEQUENCING AND EVEN OWE TYPING
ON THESE PARTICIPANTS AND
DETERMINE FREQUENCY OF RISK
ALLELES THAT ARE KNOWN FROM
EUROPEAN ANCESTRY SAMPLES TO
EXAMINE ADD MIXTURE PATTERNS AND
VARIANTS AND ALSO A THIRD AIM TO
BUILD DIAGNOSTIC AND RESEARCH
CAPACITY IN MEXICO THROUGH THE
RED LAT CONSORTIUM.
AND THE RATIONALE FOR THIS STUDY
IS VERY STRONG BECAUSE NOT ONLY
DO VERY FEW GENETIC STUDIES
INCLUDE PEOPLE WHO HAVE MEXICAN
ANCESTRY BUT IT'S EVEN LESS THAT
POPULATION IS EVEN LESS WELL
REPRESENTED IN ALZHEIMER'S
DISEASE GENETIC STUDIES SO THIS
TYPE OF WORK IS REALLY VERY
IMPORTANT.
THE RED LAT CONSORTIUM WAS
IDENTIFIED BECAUSE THEY HAVE
CONNECTIONS WITH INVESTIGATORS
AT THESE 10 DIFFERENT SITES.
THERE WAS A GREAT DEAL OF
ENTHUSIASM FROM COUNCIL ON THIS
AND WE DID HAVE A GOOD
DISCUSSION ABOUT A COUPLE THINGS
AND ONE OF WHICH IS THE
IMPORTANCE OF VERIFYING THAT NOT
ONLY CAN THE SITES HAVE THE
CAPACITY TO RECRUIT PEOPLE FROM
THESE GROUPS BUT ALSO RECRUIT
PEOPLE WITH BACK GROUNDS THAT
ARE AFRO-LATINO BACKGROUNDS AND
INDIGENOUS BACKGROUNDS WHICH IS
THE POINT OF SORT OF LOOKING AT
THE ANCESTORIAL MARKERS IN THIS
RESEARCH AND WE ALSO TALKED
ABOUT DATA OWNERSHIP.
THE THIRD AIM OF THIS PROPOSAL
IS MEANT TO INCREASE CAPACITY OF
RESEARCH IN MEXICO AND
RESEARCHERS IN MEXICO TO BE ABLE
TO USE THE DATA THAT ARE BEING
COLLECTED AND ALSO WE TALKED
ABOUT SORT OF ACCESSIBILITY.
SO THEY'VE DEVELOPED A
CLOUD-BASED SYSTEM WHERE
RESEARCH IS IN MEXICO CAN HAVE
ACCESS TO THE DATA AND WHETHER
THE HARMONIZED WITH OTHER
SPANISH LANGUAGE INSTRUMENTS
THAT ARE DEVELOPED AND VALIDATED
FOR USE IN ADRCs AND THE
UNIFORM DATA SET AND MANY
STUDIES WHICH HAVE A STRONG
PRESENCE AND ENGAGEMENT IN
MEXICO SO THERE WAS AGAIN,
STRONG SUPPORT FROM COUNCIL AND
DISCUSS ABOUT THIS RESEARCH.
>> THANK YOU, VERY MUCH.
THE NEXT CONCEPT CONTRACT
CLEARANCE WAS MULTIPLE DIVISION
AND OTHER THAN REGARDING THE
TITLE WE CAN JUST GO TO Dr.
VAN ELDIK TO EXPLAIN THIS.
>> THAT'S EASIER.
>> WE ADD THEM TO THE ANNUAL
SBIR RESEARCH REQUEST FOR
PROPOSAL SO THESE WOULD BE A
EMPLOYED FOR AS PHASE ONE PROVE
OF CONCEPT SBIR STUDIES SO, BSR
IS PROPOSING TO SOLICIT THE SBIR
CONTRACTS AND TO DEVELOP
ARTIFICIAL BASED TOOLS THAT CAN
BE USED TO ANALYZE THE
BEHAVIORAL AND SOCIAL SCIENCE
RESEARCH LITERATURE AND SO RIGHT
NOW, THERE'S A LOT OF OF
LITERATURE ABOUT DEFINING A
NETWORK OF VARIABLE SUCH
CHARACTER HE IS TICKS OF A GROUP
OR ENVIRONMENT AND THEN
POTENTIAL CAUSAL RELATIONSHIPS
BETWEEN THOSE VARIABLE AND THERE
DOESN'T EXIST ANY EASY WAY TO
QUICKLY LOOK FOR CAUSAL OVER
VIEWS AND CAUSAL POTENTIAL
CAUSAL RELATIONSHIPS AND
ASSOCIATIONS BETWEEN THESE
VARIABLES AND SO THAT IS WHAT
THINK WOULD LIKE TO HAVE SBIR
CONTRACTS COME INTO TRY TO
DEFINE THIS NETWORK OF VARIABLE
AND POTENTIAL CAUSAL
RELATIONSHIPS.
THEY WILL SOLICIT CONTRACTS TO
DEVELOP ADEVELOP AN INEXPENSIVE AND OF
INDETERMINANT POTENTIAL OR CHIP
AS SAYS AND THEY WOULD DETECT
SEMANTIC MUTATIONS IN BLOOD
CELLS THAT MIGHT BE ASSOCIATED
WITH AGING AND AGE-RELATED
DISEASE AND RIGHT NOW, THE ONLY
WAY TO DO THAT IS TO DO COMPLETE
DNA SEQUENCING ON PERIPHERAL
BLOOD AND SO THERE DOESN'T
REALLY EXIST A LOW COST OR
SCALABLE ASSAY FOR ANALYSIS OF
THESE CLINICAL POTENTIAL
MUTATION AND IT WOULD BE VERY
USEFUL FOR LOOKING AT THE
POTENTIAL AGEING AND AGE RELATED
GENETIC DISORDERS AND
NEUROSCIENCE PROPOSES TO
COLLABORATE WITH THE DEA OFFICE
OF STRATEGIC EXTRAMURAL PROGRAMS
AND SOLICIT SBIR CONTRACTS THAT
COULD DEVELOP MORE PRODUCTIVE
AND HIGH THROUGH-PUT IN VITRO,
MICRO PHYSIOLOGICAL SYSTEMS AND
THESE WOULD BE 3D CULTURE SYSTEMS
OR ORGANS ON A CHIP AND TO THAT
MAY ALIGN A LITTLE BIT BETTER
WITH THE HUMAN, ALZHEIMER'S AND
ADRD DATA AND COULD BE USED AS A
PREDICTIVE TOOL AND A SCREENING
ASSAY FOR POTENTIAL THERAPEUTIC
AGENTS AND SO THERE WAS A LOT OF
ENTHUSIASM FOR ALL THREE OF
THESE AND THEY ADDRESS A GAP AND
ADDRESS STRATEGIC GOALS OF
SUPPORTING INFRASTRUCTURE AND
RESOURCES THAT ARE NEEDED IN THE
FIELD AND OVERCOMING CHALLENGES
AND LIMITATIONS OF EXISTING
METHODS AND IMPROVING THE AD,
ADRD DRUG DEVELOPMENT PIPELINE
WITH AN INNOVATIVE APPROACH SO
THERE WAS A LOT OF ENTHUSIASM
AND IT WAS VOTED TO MOVE AHEAD.
>> THANK YOU, SO MUCH FOR YOUR
EXCELLENT COMMENTS.
WE HAVE ONE OR TWO MORE I THINK.
THAT WAS THE LAST ONE.
>> THANK YOU VERY MUCH TO ALL
THE MEMBERS OF COUNCIL FOR THEIR
REALLY WONDERFUL CONCENTRATED
AND CONSTRUCTIVE COMMENTS ON
THESE.
>> ALL RIGHT.
THANK YOU, VERY MUCH.
AND AGAIN, OUR COUNCIL MEMBERS
UNANIMOUSLY SUPPORTED ALL OF
THESE CONCEPTS.
SO, MOVING TO THE NEXT AGENDA
ITEM ON THE WORKING GROUP OF
PROGRAMS, WE HAVE A REVIEW OF
THE ANALYSIS ON THE REPORT ON
THE DIVISION OF AGING BIOLOGY
REVIEW AND ANNUAL REVIEW SO
Dr. CLIFFORD ROSEN AND Dr.
MARGARET GOODELL WERE THE CHAIRS
OF THAT COMMITTEE AND PEGGY, I
BELIEVE YOU ARE GOING TO BE
GIVING US AN OVERVIEW.
>> YES.
THANK YOU VERY MUCH.
>> Dr. ROSEN PRESENTED THE
SUMMARY YESTERDAY AND IT'S MY
OPPORTUNITY TO DO IT TODAY.
IF I COULD HAVE THE SLIDES UP.
>> JUST A MOMENT -- DO YOU WANT
ME TO GIVE A SUMMARY.
IT'S' YEAR WITH THE SLIDES.
>> YES, DWANE WILL GET THEM UP
JUST MOMENTARILY.
JUST ONE SECOND.
>> WHILE HE IS PULLING THEM UP I
CAN GIVE A LITTLE INTRODUCTION
FOR THOSE OF YOU WHO WERE NOT
HERE YESTERDAY, ALL DIVISIONS
ARE REVIEWED PERIODICALLY BY
COUNCIL MEMBERS AND THIS REVIEW
WAS DELAYED A COUPLE OF YEARS AS
THEY WERE WAITING TO APPOINT A
NEW DIVISION DIRECTOR AND IT WAS
ULTIMATELY RON KOHANSKI WHICH
WE'RE ALL VERY HAPPY SO WITH SO
IT WAS REALLY, AS RON WAS TAKING
OVER, IT WAS REALLY A GREAT
OPPORTUNITY TO REVIEW THE
CURRENT STATE OF THE DIVISION OF
AGING BIOLOGY AND TO MAKE MY
RECOMMENDATIONS ON CHANGES OF
FATAH SIS AS WELL AS NEW
DIRECTIONS GOING FORWARD AND
THIS WAS REALLY ABOUT THE REPORT AND
IT'S ABOUT 25 PAGES.
YOU ARE LUCKY IT'S NOT MUCH
LONGER THAN THAT CONSIDERING ALL
THAT WE PUT INTO IT.
SO, YES, CAN YOU GO TO THE NEXT
SLIDE.
SO, THE CHARGE OF THE REVIEW AS
YOU CAN SEE WAS TO ASSESS THE
CURRENT STATE OF THE DAB FUNDED
RESEARCH AND FOR THOSE OF YOU
WHO ARE NEW TO COUNCIL, THIS IS
THE DIVISION OF THE NATIONAL
INSTITUTE OF AGING THAT LOOKS AT
FUNDAMENTAL BIOLOGICAL PROCESSES
OF AGING AND SO IT'S REALLY
DISTINCT FROM THE OTHER DIVISION
THIS IS THAT SENSE AND INFORMS
SOME OF THE CONCEPTS THAT THEN
FILTER INTO THE OTHER DIVISIONS.
IT ALSO PRE VOIDS BIOLOGICAL
RESOURCES TO MANY RESEARCHERS
AND ASSOCIATED SCIENTIFIC EVERY
DO YODO YOUENDEAVOR.
WE WANT TO INVESTIGATE THE ROLE
AN.SO, THE REVIEW COMMITTEES ARE
LISTED HERE.
ACTUALLY, Dr. ROSEN AND I HAVE
JUST ROLLED OFF COUNCIL AND WE
WERE COUNCIL MEMBERS WHEN WE
START INSIDE AND MOST OF THE
MEMBERS OF THE COMMITTEE ARE
EITHER CURRENT OR FORMER COUNCIL
MEMBERS ANDS YOU SEE AND SO THE
NUMBER OF YEARS OF EXPERIENCE
AND WISDOM WAS CONSIDER ABLE IN
TERMS OF THE INPUT WITH ALL THE
REPORT.
I WANT TO THANK THE INDIVIDUALS
INVOLVED.
THERE WERE MANY, MANY HOURS OF
CONFERENCE CALLS, ZOOM CALLS AND
WRITING AND EDITING MULTIPLE
ROUNDS OF STAGES OF THE REPORT.
LOTS OF DIFFERENT COMMUNICATIONS
AND EVERYBODY WAS INCREDIBLY
HIGHLY ENGAGE AND CONTRIBUTED
SUBSTANTIVELY TO THE REPORT.
IT WAS REALLY REMARKABLE TO ME
HOW MUCH EVERYBODY WAS ENGAGE
AND THEY HELPED US COLLATE THE
WHOLE THING AND ALSO MANY NIA
STAFF AND DIRECTORS WERE PULLED
IN FOR VARIOUS INTERVIEWS AND
CONVERSATIONS ALONG THE WAY TO
GET A THOROUGH PICTURE OF HOW
EVERYTHING WAS WORKING.
GO TO THE NEXT SLIDE, PLEASE.
SO, WE FIRST BROKE THE GROUPS
DOWN, THE PROCESS DOWN INTO THE
BRANCHS SO WE CAN REVIEW THE
PROGRESS AS SHOWN HERE.
EACH BRANCH STUDY GROUPS HAD A
CHAIR AND INDICATED HERE AND A
SMALL GROUP OF INVESTIGATORS AND
THAT ALLOWED US TO GET
INFORMATION ON EACH OF THE
BRANCHES AND THEN WE CAME BACK
TOGETHER TO WORK ON THE MORE
DETAILS REPORT, THE OVERVIEW
AFTER THAT.
THIS IS JUST A OVERVIEW OF THE
TIMELINE THAT YOU CAN SEE THAT
WE REALLY STARTED ALMOST A YEAR
AGO AND WE CAME TOGETHER AND
MULTIPLE OCCASIONS IN VARIOUS
WAYS, MANY, MANY E-MAILS AS WELL
AS THE VIDEO CONFERENCE AND SO
FOURTH.
SO, THE INFORMATION THAT WE
GATHERED CAME FROM A LOT OF
MATERIALS THAT RON AND HIS TEAM
PULLED TOGETHER.
THE ORIGINAL REVIEW REPORT AND
THEIR RECOMMENDATIONS
ORGANIZATIONAL CHARTS, PROGRAM
DESCRIPTIONS THAT CAME FROM
STAFF, VARIOUS STATISTICS ON
FUNDING, THE RFAs AND SO
FOURTH.
SO, FIRST OF ALL, WE COLLATED A
LOT OF THIS INFORMATION WHICH WE
HAD TO DIGEST, DISCUSS AND WE
INTERVIEWS MEMBERS OF DAB AND
OUTSIDE OF DAB FURTHER.
SO I JUST WANT TO TOUCH ON THESE
RECOMMENDATIONS.
IT'S JUST THE HIGH-LEVEL
OVERVIEW BUT YOU CAN READ THE
THE REPORT WHICH WAS REALLY
THOUGHTFULLY PUT TOGETHER, I
THINK.
SO FIRST, I'LL SAY THAT OVER
ALL, WE WERE VERY IMPRESSED WITH
WHERE DAB WAS AND WHAT IT HAD
CONTRIBUTED SO FAR AND SO WE
WERE REALLY COMPLIMENTARY ABOUT
ALL THE ACCOMPLISHMENTS AND FELT
THAT VERY HIGHLY IMPACTFUL
RESEARCH WAS FOCUSED ON MANY
IMPORTANT AREAS THAT WE THOUGHT
WERE THE RIGHT THING TO DO.
WE ALSO FOUND SOME OPPORTUNITIES
FOR GROWTH AND MOSTLY IT'S SORT
OF CHANGES OF EMPHASIS AND SOME
REAL EXPANSIONS INTO CERTAIN
AREAS WHICH I WILL TOUCH ON
NEXT.
AND WE HAVE RECOMMENDATIONS IN
EACH OF THE TOPIC AREAS THAT YOU
SEE HERE, SCIENTIFIC DIRECTIONS,
THE RESOURCES, HUMAN SUBJECTS
AND HEALTH DISPARITIES RESEARCH,
TRAINING AND EDUCATION AND
INTERACTIONS WITH COMMON FUND
AND COLLABORATION ACROSS NIA AND
STAFFING.
SO, FIRST OF ALL, THE SCIENTIFIC
DIRECTIONS AND I WOULD SAY THAT
THIS IS WHAT WE STRUGGLED MOST
WITH BECAUSE REALLY THINKING
ABOUT WHERE THIS SCIENCE SHOULD
GO IN THE FUTURE, IS A VERY
CHALLENGING THING TO LOOK INTO
YOUR CRYSTAL BALL AND THINK
ABOUT HOW THE WORLD IS CHANGEING
AND HOW SCIENCE IS CHANGING AND
HOW NIA AND NDAB IN PARTICULAR
CAN HAVE THE GREATEST IMPACT.
SO DAB MANAGE THIS IS EXTENSIVE
RESEARCH PORTFOLIOS, WITH THESE
BRANCHES INDICATED HERE ON THE
RIGHT WITH AN EMPHASIS ON FEE
LOGICAL SYMPTOMS, VALUABLE AND
COST EFFECTIVE RESOURCES FOR
RESEARCHERS AND ALSO GENERATING
IMPRESSIVE AMOUNTS OF DATA.
SO ONE OF THE AS PARTICULARS ASPECTS IS TH E
HALLMARKS OF AGEING AND THIS
REALLY GREW OUT OF A HALLMARKS
OF CANCER CONCEPT THAT WAS
DEVELOPED 20 YEARS OR SO AGO, SO
EVENTUALLY HALLMARKS OF AGING
WAS DEVELOPED AND I'M NOT SURE
WHAT YEAR IT WAS PUBLISHED BUT A
FEW YEARS AGO, AND SO WE HAD
QUITE A FEW DISCUSSIONS AROUND
THAT AND THE VALUE OF IT AND
ALSO HOW IT SHOULD BE MODIFIED.
BECAUSE CERTAINLY NEW FINDINGS
HAVE BEEN MADE OVER THE PAST 10
YEARS AND SO WE THAWED THAT
THERE'S A LARGER MODEL OF AGING
BIOLOGY THAT SHOULD BE USED TO
RE-EVALUATE THE HALLMARKS OF
AGING AND THAT DAB COULD HAVE A
ROLE IN UPDATING THAT HALLMARKS
AND THEN IT COULD BE USED TO
GUIDE FUTURE FUNDING.
IN TERMS OF CELL BIOLOGY THERE'S
A LOT OF GREAT WORK ALREADY ON
COMMON MECHANISMS OF AGING SUCH
AS NAD RESEARCH, AND WE FELT
THAT THIS COULD BE EXPANDED
PARTICULARLY IN THE YEARS OF
CELLULAR COMMUNICATION.
THIS IS REALLY AN AREA IN
GENERAL AND THE BROADER BIOLOGY
BASIC BIOLOGY FIELD AND THAT IS
GROWING AND WITH SOME REAL
IMPACT AND I THINK WILL HAVE
IMPACT ON THE BASIC BIOLOGY OF
AGING BUT ALSO IN THE AREA OF
ALZHEIMER'S RESEARCH AND SUCH AS
LIQUID CONDENSATION AND THESE
ARE NEW EMERGING CONCEPTS WHICH
ARE THOUGHT TO BE VERY IMPORTANT
BROADLY.
SO, EMPHASIS IN THAT AREA WILL
BE USEFUL.
WE ALSO THOUGHT IT WAS IMPORTANT
TO SUPPORT THE DISCOVERY AND
VALIDATION OF AGING BIOLOGY AND
CURRENTLY THE BIOMARKERS OF
AGING HAVE BEEN VERY UNITSFUL
BUT IT'S AN ALPHABET SOUP OF
MARKERS THAT ARE APPLIED
DIFFERENTLY IN DIFFERENT WAYS
AND WE THOUGHT THAT DAB COULD BE
A ROLE IN CONDENSING TA THAT COMING
UP THE FIELD FOCUS AN -- ANDTHAT WOULD REA LLY HELPFUL THE
TIRE FIELD MOVE FORWARD RATHER
THAN JUST CREATING MORE
BIOMARKERS, THE VALUE OF WHICH
IS NOT ONLY PERFECTLY CLEAR.
THERE'S A HUGE AMOUNT OF DATA
BEING GENERATED IN THE FIELD IT
WAS FELT THAT DAB COULD FURTHER
SUPPORT THE ANALYSIS OF THAT BY
STRENGTHENING BIO INFORM AT
TRICKS AND OTHER RESOURCES
INCLUDING DATABASES THAT CAN BE
MIND.
IN TERMS OF INTEGRATED
PHYSIOLOGY, THERE ARE
OPPORTUNITIES IN SYSTEMS BIOLOGY
TO REALLY TAKE ADVANTAGE OF
LARGE DATA RESOURCE THAT'S ARE
OCCURRING AND LARGE OF MANY
DIFFERENT TYPES AND SYSTEMS
BIOLOGY IS A GROWING AREA IN THE
BROADER FIELD.
ALSO, WE THOUGHT IT WOULD BE
USEFUL TO CONTINUE TO SUPPORT
EXPAND WORK ON CIRCADIAN BIOLOGY
AT THE EXPOS OWN AND LIFESTYLE
FACTORS AND INCREASE SUPPORT
TOWARDS RESEARCH, EXAMINING STEL
CREM AGING AND RESILIENCE.
AND FINALLY, THERE WAS A LOT OF
DISCUSSION AROUND THE IMPACT OF
EARLY TO MID LIFE STRESSORS.
I WOULD SAY IN GENERAL, THE
BASIC BIOLOGY OF AGING HAS
FOCUSED ON PHENOTYPES AND
MECHANISMS THAT ARE FOUND IN
AGED INDIVIDUALS AND WE
DISCUSSED A FAIR BIT ABOUT HOW
EARLY IN MID LIFE EXPERIENCES,
CAN SHAPE THAT MORE THAN MAYBE
IT WAS APPRECIATED 10 YEARS AGO
SO THIS IS REALLY AN OPPORTUNITY
TO THINK ABOUT ITS CHALLENGING
TO WORK ON BUT WE THINK THAT
IT'S SOMETHING THAT DAB CAN
REALLY CONTRIBUTE TO.
LET'S SEE.
NEXT SLIDE, PLEASE.
SO, IN TERMS OF THE BIOLOGICAL
AND DATA RESOURCE BRANCH, WE
REALLY FEEL THIS IS A CROWN
JEWEL IN WHAT DAB PROVIDES TO
THE BROADER AGING COMMUNITY.
THE RESOURCES SUCH AS THE AGED
MOUSE RESOURCES REALLY
INVALUABLE TO THE COMMUNITY
PROVIDING ANIMALS THAT ARE AGED
THAT RESEARCHERS COULD OTHERWISE
NOT SUSTAIN OR AFFORD AND SO WE
HAVE A LOT OF SUPPORT FOR THIS
AND WE THINK IT'S INCREDIBLY
WELL RUN AND THE MICE ARE AND
OTHER ANIMALS ARE WELL
DISTRIBUTED, WHAT WE FELT COULD
BE APPROVED WAS UNDERSTANDING
WHERE THESE ANIMALS GO AND THE
IMPACT OF THAT WORK BECAUSE
THERE ARE VERY FEW METRICS THAT
ARE AVAILABLE TO UNDERSTAND,
WELL, IF THESE ARE DISTRIBUTED,
THERE ARE GROUPS OR QUESTIONS
THAT THEY HAVE BEEN BETTER USED
FOR THAN OTHERS.
AND THAT THAT MIGHT HELP MODIFY
THAT RESOURCE OVER TIME.
THERE ARE MANY CHALLENGES WITH
COLLECTING THAT DATA BECAUSE IT
TAKES MANY YEARS OFTEN FROM
PROVIDING THE RESOURCES TO
SEEING WHAT THE OUTPUT IS IN
TERMS OF SCIENTIFIC PAPERS BUT
THIS IS SOMETHING THAT REALLY WE
THINK THAT SHOULD BE ADDRESSED
OVER TIME.
THERE ARE A NUMBER OF EMERGING
TECHNOLOGIES THAT COULD BE
FURTHER INTEGRATED INTO ANIMAL
MODEL EFFORTS AND THERE'S
ACCESSIBILITY AND CONSISTENCY TO
STANDARDIZE LAB METHODS IN
GENERAL AND I WAS JUST REFERRING
TO THE BIOMARKERS AND EVEN
WITHIN A CERTAIN BIOMARKER AND
MIGHT BE APPLIED DIFFERENTLY AND
WE FELT DAB COULD CONTRIBUTE TO
MORE UNIFORMITY OF METHODS
AROUND QUESTIONS OF AGING
BIOLOGY THAT WILL HELP THE FIELD
MOVE FORWARD.
AND THEN, FINALLY, DATA
ACCESSIBILITY AND CURATION.
I'VE ALREADY REFERRED TO THE
MASS AMOUNTS OF DATA THAT ARE
BEING GENERATED BY THE FIELD AND
WE FEEL THERE'S A ROLE THAT DAB
AND THE BROADER NIH CAN PROVIDE
IN CURATING THE DATA DETERMINE
WHAT IS SHOULD BE RETAINED AND
WHAT NOT RETAINED AND
ESTABLISHING A LONG-TERM PLAN TO
IMPROVE ACCESSIBILITY AND DATA
PRESERVATION.
NEXT SLIDE, PLEASE.
FINALLY, I WOULD SAY IN GENERAL,
DIVISION OF AGING BIOLOGY DOES A
LOT LESS HUMAN SUBJECTS RESEARCH
THAN THE OTHER DIVISIONS AND WE
FELT THAT IT COULD STILL PLAY A
ROLE IN UNDERSTANDING HEALTH
DISPARITIES AND ESPECIALLY IN
TERMS OF BIOMARKERS OF AGING AND
UNDERSTANDING DIFFERENT
MECHANISMS AND DIFFERENCES IN
THE BOYOLOGY OF AGING AND
PROMOTE EXAMININPROMOTING BIO MARKER IN DI VERSE
POPULATIONS.
THERE'S A LOT OF DISCUSSION
ABOUT HOW DAB CAN CONTRIBUTE TO
THIS IMPORTANT ENDEAVOR EVEN
THOUGH IT'S NOT A HUGE VENUE FOR
HUMAN SUBJECTS RESEARCH ITSELF.
NEXT SLIDE, PLEASE.
FINALLY, WE DISCUSSED TRAINING
AND EDUCATION AND OUTREACH
PROGRAMS.
WE TALKED ABOUT THE IMPORTANCE
OF THAT AND BRING DIVERSE
INVESTIGATORS INTO THE FIELD AND
I THINK DAB IS DOING A LOT IN THIS
AREA AND WE LOTTED THAT.
WE HAD OTHER SUGGESTIONS ABOUT
REACHING OUT MORE TO MINORITY
SERVICING INSTITUTIONS TO
ENCOURAGE THOSE INVESTIGATORS TO
ENGAGE WITH DAB AND INVESTIGATOR
INITIATIVES AND INCLUDING SUCH
AS THE SHOCK CENTERS AND SO
FOURTH SO WE FELT THERE WERE A
NUMBER OF OPPORTUNITIES THERE
THAT COULD BE FURTHER EXPANDED
EVEN THOUGH THEY'RE ALREADY
REALLY DOING A GREAT JOB IN THAT
AREA.
SO IN TERMS OF COMMON FUND AND
COLLABORATIVE ACTIVITIES WE
STARTED THINKING WELL, DAB COULD
DO A LOT MORE TO COLLABORATION
WITH OTHER DIVISIONS IN THE NIA
BUT WE REALIZED THERE WAS A LOT
OF COLLABORATION AND NOTER
ACTIOANDINTERACTION AND WE THOUGHT THEY
WERE DOING A GREAT JOB IN THAT
AND PARTICIPATING IN BROADER NIH
COMMON FUND PROGRAMS AND I'M
SURE THERE'S MORE OPPORTUNITIES
WHERE THAT LIES AND WE HAVE SOME
OF THOSE DETAILED IN THE REPORT
AS WELL.
YOU CAN GO INFORM TH GO TO THE NEXT SLIDE.
THIS WAS SOMETHING THAT WE WERE
VERY PLEASED TO SEE.
IT WAS ALREADY IN PROGRESS AND
IT'S CLEAR THAT DAB WAS SOMEWHAT
UNDERSTAFFED AND PARTICULARLY
MANAGING A SIGNIFICANT GRANT
PORTFOLIO AND PROGRAM OFFICERS
WERE NEEDED AND BY THE TIME RON
CAME ON, A NUMBER OF THAT STAFF
EXPANSION WAS ALREADY APPROVED
AND THANK YOU TO Dr. HODES AND
SO WE SPENT A LITTLE BIT OF TIME
CONSIDERING THAT AND WHAT KIND
OF EXPERTISE SHOULD BE ENHANCED
AT DAB AND SO ON AND SO FOURTH.
OBVIOUSLY THIS IS A VERY
IMPORTANT AREA TO SUPPORT
RESPONSIBLE USE OF DAB FUNDS.
SO NEXT SLIDE.
THE FINAL SLIDE, REALLY IT'S
JUST TO AGAIN HIGHLIGHT THE KEY
TAKEAWAYS, WHICH ALL OF THIS WAS
BOILED DOWN NOW, THIS 25-PAGE
AND MANY, MANY HOURS INTO THIS
SLIDE.
SO THE KEY TAKEAWAYS, CONSIDER
HOW THE HALLMARKS OF AGING
SHOULD BE ADAPTED TO FIT THE
COMING DECADE.
TO BROADEN DAB EMPHASIS ON KEY
SCIENTIFIC TOPIC AREAS WHICH I
HIGHLIGHTED A MOMENT AGO.
DEVELOP SOME METRICS OF SUCCESS
OF HOW THE VALUABLE RESOURCES
THAT DAB PROVIDES ARE DEPLOYED
TO ENSURE THAT THEY CONTINUE TO
BE UTILIZED IN THE BEST MANNER
POSSIBLE.
CONTINUE AND EXPAND AND SUPPORT
WORK ON DIVERSE AND
REPRESENTATIVE HUMAN SUBJECTS.
CONDUCT EDUCATION AND TRAINING
EFFORTS TO PROMOTE GEROSCIENCE
AND OTHER DAB-RELATED TOPICS AND
LEVERAGE DAP'S UNIQUE IDENTITY
IN ITS COLLABORATIVE EFFORTS
WITHIN THE NATIONAL INSTITUTE OF
AGING AND OUTSIDE AND CONTINUE
STAFFING TO ACCOMPLISH OUR
RECOMMENDATION AND I'LL STOP
THERE AND TAKE ANY QUESTIONS.
THANK YOU, VERY MUCH.
>> TERRIFIC, THANK YOU, VERY
MUCH, PEGGY, FOR THAT GREAT
OVERVIEW OF THE RECOMMENDATIONS
FROM THE REVIEW OF THE DIVISION
OF AGING BIOLOGY.
ANY QUESTIONS?
REGARDING THE REPORT?
OR ANY OTHER QUESTIONS FROM ANY
OF THE OTHER CONCEPT THAT'S WAS
JUST REVIEWED?
>> I HAVE A QUESTION.
IT WAS REALLY ENJOYED THAT BEING
BEING NEW AND LEARNING ABOUT THE
AGING BIOLOGY EFFORTS AND I CAN
SEE IT'S A LOT OF WORK TOO.
IN THE AREA OF PEOPLE TALKING
ABOUT CANDIDATE THERAPEUTICS,
LIKE SAY NET FOREMEN OR
SOMETHING AND CLAIMS OR IDEAS
ARE MADE ABOUT AGING MECHANISMS,
FOR PEOPLE INTERESTED IN THAT
AREA, WHAT WOULD BE THE
INTERFACE?
WITH THE WHOLE REALM THAT YOU
JUST DESCRIBED HERE?
IN THAT PROGRAM?
>> I'M NOT SURE WHAT YOU MEAN BY
THE INTERFACE?
LIKE GRANT OPPORTUNITIES OR --
>> YEAH, JUST GRANT
OPPORTUNITIES.
GRANT OPPORTUNITIES WOULD BE ONE
OR JUST WAYS TO PURSUE THESE
TYPES OF AREAS THAT HAVE
THERAPEUTIC IMPLICATIONS OR
CLAIMS FOR THOSE AND I GUESS
IT'S GRANT OPPORTUNITIES.
OR GUIDANCE BASICALLY.
HOW DO YOU THINK ABOUT THESE
KINDS OF THINGS?
>> IT'S A GREAT QUESTION.
IT WAS A CHALLENGE.
OUR GROUP IS VERY DIVERSE AND
EVERYONE COMES IN WITH OUR OWN
RESEARCH BIASES, OK.
SO THAT WAS GOOD AND BAD, RIGHT.
BECAUSE IT MAKES A VERY BALANCED
REPORT TO SOME EXTENT AND WE
TRIED NOT TO COME ACROSS WITH
TOO MANY STRONG RECOMMENDATIONS
THAT THIS IS GOOD AND THIS IS
BAD.
ALL OF US COULD GIVE OUR
OPINIONS BUT IT WASN'T OUR
REMIT.
IN AN AREA OF CONTROVERSY ABOUT
THERAPEUTICS, WE TRIED TO
ENCOURAGE MORE RIGOROUS RESEARCH
AROUND A CERTAIN TOPIC AND IT'S
REALLY GOING TO BE UP TO Dr.
KOHANS CAN I TKI TO HAVE INVESTIGATORS
TO SUBMIT NON SOLICITED RO1s,
AND SUCH ON THAT AND IT'S CLEAR
THERE ARE LOTS OF AREAS, I
WOULDN'T SAY CONTROVERSIES,
MAYBE TOO STRONG BUT DIFFERENCES
OF OPINION AND I DO THINK THAT
D AB CAN HAVE A REL IN HELPING
TO SORT THAT OUT AND THE BIO
MARKER FIELD THAT I JUST
REFERRED TO IS KIND OF WIN OF
THOSE AND AGAIN IT ISN'T
CONTROVERSIAL BUT IT'S REALLY A
BROAD SWATH AND I THINK DAB CONE
COURAGE SOME MORE UNIFORMITY
THAT REALLY WOULD HELP MOVE THE
NEEDLE IN AGING PEOPLE.
>> THANK YOU.
THAT MAKES SENSE.
YEAH.
>> THANK YOU.
ANY FURTHER QUESTIONS OR
COMMENTS?
>> KEN, CAN I MAKE A COUPLE
COMMENTS.
FIRST, I WANT TO CONGRATULATE
YOU, PEGGY AND CLIFF FOR YOUR
OUTSTANDING LEADERSHIP OF THIS
MAMMOTH EFFORT.
JUST A COUPLE OF PARTS THAT YOU
TOUCHED UPON.
ONE IS IN THE GEROSCIENCE AND
PILLARS OF AGING IT'S AN
EXCITING NEW AREA AND IT'S
WORTHY OF SUPPORT AND
ENCOURAGEMENT.
AND I JUST WANT TO REINFORCE THE
POINT THAT YOU MADE, AT THIS
STAGE, IT'S VERY EARLY IN THE
PHASE AND A LOT OF THE DATA IS
EARLY AND CONCLUSIVE SO I THINK
IT'S TOO EARLY TO PICK WINNERS
AND LOSERS IN THIS FIELD AND A
BROAD SUPPORT OF THE GEROSCIENCE
IS THE WAY TO GO.
GEROUX SCIENCE.
THE OTHER THING THAT SOME
BALANCE BETWEEN CON THE PROGRAM
INITIATED FUNDING OPPORTUNITIES
AND THE INVESTIGATORS INITIATED
RO1 MECHANISMS, RO1 IS THE CROWN
JEWEL OF NIH.
PEOPLE ARE DOING THEIR OWN
THINGS AND A LOT OF INNOVATIVE
WORK GETS DONE BY LOAN RANGERS
AROUND THE COUNTRY SO I THINK
WITH THE PAY LINES AS LOW AS
THEY ARE ACROSS NIA, PAYING
ATTENTION TO THE BALANCE TO
PERHAPS BRING THE PAY LINES FOR
RO1s INVESTIGATORS ANYWHERE
TIVE RO1s TO A HIGHER LEVEL
WOULD BE VERY WORTH WHILE.
>> THANK YOU FOR THOSE COMMENTS.
>> ANY OTHER?
>> ALL RIGHT.
THANK YOU, VERY MUCH.
THANK YOU PEGGY.
AGAIN, FOR THE GREAT SUMMARY OF
THE DIVISION OF AGING IDEOLOGY
REPORT.
SO, OUR NEXT UP WE HAVE OUR TWO
SPEAKERS BUT BEFORE WE INTRODUCE
THEM, I JUST WANT TO GIVE
EVERYONE A FIVE-MINUTE BREAK AND
THEN WE'LL RECONVENE, WELL LET'S
MAKE IT FOUR MINUTES.
12:10.
IF EVERYONE CAN, SORRY, DAREN.
WE'LL JUST RECONVENE IN FIVE
MINUTES.
ALL RIGHT.
THANK YOU, VERY MUCH.
>>IT'S MY ABSOLUTE PLEASURE TO
INTRODUCE OUR PROGRAM HIGHLIGHTS
SPEAKER Dr. NOAH
SNYDER-MACKLER AND FROM THE
SCHOOL OF LIGHT SCIENCES AT
ARIZONA STATE UNIVERSITY AND HE
WILL TALK ABOUT INTERESTING
RESEARCH FINDINGS THAT HAVE COME
OUT OF THIS ON GOING NIA-FUNDED
RO1 PROJECT AND SOCIAL MODIFIERS
OF AGING AND THIS BUILDS ON HIS
RESEARCH THAT HE WAS CONDUCTING
UNDER HIS NIA FUNDED K99 ROL
AWARD WHICH HE RECEIVED AS A
RESEARCH A FILL AT BEFORE
TRANSITIONING TO HIS FACULTY
POSITION AND THE DEPARTMENT OF
PSYCHOLOGY AT THE UNIVERSITY OF
WASHINGTON.
HE WAS PART OF THE UWU SHOCK
CENTER OF THE EXCELLENCE AND
BASIC BIOLOGY OF AGING AND HE
WAS ALSO PART OF THE T32 TEAM.
HE COMPLETED HIS BACHELORS IN
PH.D AT PENN AND A POSTDOC AT
DUKE WITH NIA GRANTEE JENNY WHO
WAS MEN FORWARD TO BY A NIA
GRANTEE.
AND AT DUKE, Dr A TRAINEE AT THE
DUKE CENTER FOR STUDY OF AGING
AND AT HUMAN DEVELOPMENT AND I'M
PLEASED TO SAY THAT HE IS
CONTINUING THIS TRADITION OF NIA
FUNDING AND PASSING IT DOWN AS
HE IS CURRENTLY THE MENTOR OF
MARINA WATERWHICH, ONE OF NAI
F-3 1 GRANTEE WHO IS RESEARCH
WILL BE DISCUSSING DURING HIS
TALK AND HE IS ALSO MENTORING
OTHERS WHO ARE CURRENTLY IN THE
FUNDING PO PIPELINE AND MENTORING
ONE OF THE TWO DIVERSITY
SUPPLEMENT GRANTS THAT ARE
AWARDED TO HIS RO1 AND THAT IS
MITCHELL SANCHEZ ROSATO A PH.D
STUDENT AT THE UNIVERSITY OF
PUERTO RICO MEDICAL SCIENCES
CAMPUS.
THE MPI IN NIA FUNDED R56 AND HE
IS CO INVESTIGATOR ON NIA DOG
AGING PROJECT AND PI OF AN MPIUO
MPIUO.
MY INTERNET NEWT IS UNSTABLE I'M
AT A CONFERENCE AT COLD SPRING
HARBOR RIGHT NOW.
>> THANK YOU FOR THAT WONDERFUL
INTRODUCTION MELISSA AND THANK
YOU FOR IN INVITING ME HERE TO
SPEAK.
I'VE BEEN FORTUNATE TO BE
SUPPORTED BY NIA THROUGHOUT MY
TRAINING AND MY EARLY CAREER AND
THAT HAS BEEN PASSED ON AND I
HOPE IT CONTINUE THAT TRAINING
AND DEVELOPMENT OF THE NEW AND
UPCOMING AGING RESEARCHERS SO
I'M REALLY GRATEFUL.
I WILL TALK ABOUT HOW
ENVIRONMENTAL ADVERSITY CAN
ALTER AGING.
IT WILL BE BREAKEN INTO TWO
PARTS.
THE FIRST ABOUT HOW EXPOSURE TO
AND THE SECOND SHORTER PART WILL
BE ABOUT HOW VARIATION IN THE
SOCIAL ENVIRONMENT MIGHT PLAY A
ROLE IN MITIGATING SOME OF THESE
COSTS.
THE GOAL IS TO GAIN A BETTER
UNDERSTANDING OF THE HEALTH
CONSEQUENCES OF VARIATION IN THE
ENVIRONMENT.
AND I'M TALKING ABOUT THE
ENVIRONMENT IT'S NOT JUST THE
PHYSICAL ENVIRONMENT AND YOUR
EXPOSURE BUT ALSO YOUR SOCIAL
ENVIRONMENT.
AND UNDERSTAND HOW ORGANISMS
NAVIGATE THEIR ENVIRONMENT AND
THE CONSEQUENCES AND HOW THIS
MIGHT HELP US BETTER UNDERSTAND
HUMAN HEALTH AND DISEASE.
AND ABOUT MUCH OF THE WORK IN MY
LAB IS DONE WITHIN THE CONTEXT
OF AGING AND TO SEE IF HOW AND
WHEN THE ENVIRONMENT MIGHT EXERT
ITS IMPACT.
WHY AGING?
THERE ARE A NUMBER OF REASONS.
THE FIRST REASON IS THAT AGE IS
THE STRONGEST RISK-FACTOR FOR
MOST DISEASES.
AND WE ALL KNOW THIS IS THE
PREMISE OF GEROSCIENCE.
RATHER THAN PLAYING WHACK A MOLE
WITH TRYING TO TREAT INDIVIDUAL
WITH DISEASES WE CAN TRY AND
FIND SLOW THE AGING AND PROCESS
AND DELAY THE ONSET INDOOR
PROGRESSION AND MANY DISEASES
AND AND THE WORLD IS GETTING
OLDER AND BY THE IF NEXT FEW
DECADES, MORE THAN 1/5 OF THE
POPULATION WILL BE OVER 60.
THIS PROBLEM WILL COMPOUND AND
HAVE A DRAMATIC IMPACT ON OUR
HEALTH-CARE SYSTEM AND OUR
FINANCIAL SYSTEM AND FINALLY THE
REASON WHY WE CAN LOOK AT
ADVERSE TEASE AND EXPOSURES TO
ADVERSITY THEY REKA PIT LATE OR
INDUCE EARLIER ONSET OF AGE
RELATED DISEASE AND HERE I'M
SHOWING YOU THREE DIFFERENT
EXPOSURES TO SOCIAL ADVERSE
TEASE AND YOU
CAN SEE THAT IN THE LEFT SIDE OF
THE FIGURES, WHERE THEY'RE
HIGHER LEVELS OF EXPOSURE TO
ADVERSITY, THERE ARE HIGHER
INCIDENTS OF ADJUSTED ODDS
RATIOS OF MANY DISEASE THAT'S
ARE ASSOCIATED WITH AGING.
IN FACT, I'M SURE THE SIMILARITY
BETWEEN CHRONIC STRESS OR
CHRONIC EXPOSURE TO ADVERSITY
SOMETHING WE'RE ALL FAMILIAR
WITH AND WHEN WE'RE CHRONICALLY
STRESSED WE MAY AGE BEFORE AND
SO SOME RECENT WORK COMING OUT
OF COLOMBIA, SHOWED THAT WE CAN
SEE THIS AND RELIEVED BY THE
SUBMISSION OF AN RO1 RENEWAL.
AND THE QUESTION IS, ARE THESE
STRESS INDUCED CHANGES
RECAPITULATING AGING AT THE
MOLECULAR LEVEL SO DO EXPOSURES
TO ADVERSITY OR STRESS E.
ACCELERATE THE AGING PROCESS AND
IT'S GOING TO BE OF INTEREST TO
POLICYMAKERS, MOTIVATED TO
CONTRIBUTE TO POLICY THAT MIGHT
IMPROVE HUMAN HEALTH AND THROUGH
CHANGES IN THE ENVIRONMENT AND
IN MEDICAL DOCTORS WHO MIGHT
WANT TO FIND WAYS TO TREAT
DISEASES LINK TO ENVIRONMENTAL
CHANGE.
AND NOW DURING MY POSTDOC WITH
JENNY, I WAS FUNDED ON A T32
FROM NIA WE TESTED THIS
HYPOTHESIS AND THIS MOLECULAR
EMBEDDING THE SOCIAL ENVIRONMENT
TO SEE IF ONE SALIENT FACTOR
SOCIAL ADVERSITY IN THESE
MONKEYS SHOWN AT HIGH STATUS
LOWER TO ADVERSITY ON THE LEFT
AND SHOW STATUS HIGHER ADVERSITY
ON THE RIGHT.
AND WE FOUND THAT THERE ARE
REALLY BROAD GENE EXPRESSION
SIMILARITIES IN IMMUNE CELLS
BETWEEN LOW STATUS MONKEYS AND
HOLDER HUMANS DRAWING ACROSS TWO
PUBLISHED DATASETS.
AND SO THIS IS DONE ACROSS
SPECIES AND STUDIES AND IT WAS
REALLY A FIRST PASS A SESSION
THIS PATHWAYS.
THIS IS DONE WHILE I WAS
TRAINING AT DUKE AND IT SET ME
ON MY CURRENT TRAJECTORY AND I'M
IDENTIFYING ABOUT IDENTIFYING
THE MOLECULAR CONSEQUENCES OF
ADVERSITY AND AGING AND HOW WE
MIGHT HARNESS THIS KNOWLEDGE TO
IMPROVE HUMAN HEALTH.
NOW IN THE LAST SLIDE AND I MADE
THIS ASSUMPTION THAT THE CATS
ARE A GOOD MODEL FOR HUMANS.
WE ALL MAY NOT BE ON BOARD WITH
THIS IS AUTOMATICKION AN AND IT MIGHT BE B ETTER TO
LOOK IN HUMANS AND OTHERS IN
CONTROLLED SYSTEMS OF MODEL
ORGANISMS LIKE YEAST, FLY,
RODENTS AND THAT HAVE DONE
WONDERS FOR US IN TRYING TO
UNDERSTAND THE BASIC BIOLOGY OF
AGING.
AND THESE SPECIES ARE A LITTLE
BIT MORE RELATED TO HUMANS AND
HUMANS ARE COMPLEX AND WE HAVE
MUCH LESS CONTROL OVER THERE
ENVIRONMENTS AND WE'RE ALSO LESS
ABLE TO COLLECT COMPREHENSIVE
SAMPLING FROM HUMANS AND THESE
LIMITATIONS THAT ARE BRIEFLY
MENTIONED, UNDERSCORE THE NEED
TO EXAMINE BASIC MECHANISMS OF
AGING AND A MORE SYSTEMATIC
MANNER AND THE NON HUMAN
PRIMATES.
WE SHOULD ALSO LEVERAGE TO THE
FACT THAT LIKE OTHER NON HUMAN
PRIMATES, THEY SHOW A COMPRESSED
LIFESPAN COMPARED TO HUMANS AND
IT MEANS THAT WE AS RESEARCHERS
CAN FEES BLEE OBSERVE THE
LIFESPAN AND WHILE AT THE SAME
TIME THESE ANIMALS SHARE MUCH OF
THEIR PHYSIOLOGY WITH HUMANS AND
MAKING THEM A WONDERFUL MODEL.
IN FACT, IN A RECENT PUBLICATION
LED BY KENNY CHIU, WE
DEMONSTRATED STRONG SIMILARITIES
AND HOW AGE EFFECTS AND HERE I'M
JUST SHOWING IF YOU A GENE WAS
MORE HILY PRESSED IN OLDER MA
MACAQUES AND WHY NOT JUST STUDY
HUMANS AND THERE ARE MANY
ADVANTAGES TO STUDIES THESE
MAC MA CONTACTS AND THE PRIME AT
WORK THE REAL POWER -- SO NOW WITH
EVERYONE, OF COURSE ON BOARD
WITH THE FACT THAT MACAQUES ARE
A WONDERFUL MODEL FOR HUMAN
AGING I'LL TELL YOU ABOUT A
STUDY EXAMINING SOME OF THESE
MOLECULAR CHANGES THAT OCCUR IN
RESPONSE TO A ENVIRONMENTAL
RESPONSE AREA FOR MACAQUES.
APOLOGIZE THIS VIDEO IS
SKIPPING.
MUCH OF THE WORK REINVOLVES
AROUND MONKEYS IN THE COAST OF
PUERTO RICO.
THESE MACAQUES ARE NOT NATIVE TO
PUERTO RICO.
THEY'RE NATIVE TO ASIA AND THIS
RESEARCH COLONY WAS FOUNDED IN
1938 WHEN 40 MACAQUES WERE
BROUGHT FROM INDIA AND WERE
RELEASED ONTO THE ISLAND.
TODAY THERE ARE ABOUT 1500
MONKEYS ON THE ISLAND THAT ARE
THE DIRECT DESCENDANTS OF THE
FOUNDING POPULATION AND MANAGE
THE BY THE UNIVERSITY OF PUERTO
RICO.
THEY HAVE FOOD AND GENERALLY
LEFT TO THEIR OWN DEVICES.
APART FROM ONCE A YEAR WHEN
THESE ANIMALS CAN BE TRAPPED TO
OBTAIN BIOLOGICAL SAMPLES, THIS
ALLOWS US TO COLLECT SOME REALLY
DETAILED LODGE ATTITUDE NAL DATA
AND IT REPRESENTS A REALLY
PHENOMENAL NATURAL LAB.
THIS HYBRID BETWEEN THE FIELD
AND THE CONTROLLED LAB, THAT
THESE ORGANISMS LIVED IN.
I STARTED AT THE UNIVERSITY OF
WASHINGTON AND THREE DAYS LATER
CATEGORY 4 HURRICANE MADE A HIT
ON THE ISLAND ARE THE PUERTO
RICO.
DEVASTATING THE ISLAND AND
LEAVING MASSIVE DAMAGE IN ITS
WAKE.
MUCH OF THE ISLAND, INCLUDING
THE PEOPLE AND THE
INFRASTRUCTURE, IS STILL VERY
MUCH RECOVERING, ALMOST FIVE
YEARS LATER.
THE HURRICANE PASSED OVER
SANTIAGO AND YOU CAN SEE RIGHT
THERE IN THE EYE OF THE
HURRICANE.
AND THIS HAPPENED IN
SEPTEMBER 2017, AND IMMEDIATELY
MY COLLEAGUES AND I KICKED IT
INTO HIGH GEAR WITH OUR PRIMARY
GOAL BEING TO INSURE OF THE
SAFETY OF OUR COLLEAGUE, FRIENDS
AND FAMILIES, THOSE IN PUNTA
SANTIAGO WHERE MOST OF THE STAFF
ARE AND THE OFFICES FOR THEIR
PRIME AT CENTER SPECIFICALLY CYO
ARE HOUSED AND THAT WAS ALSO AS
CAN YOU SEE IN THIS INSET, ONE
OF THE FIRST AREAS IN PUERTO
RICO TO BE HIT BY HURRICANE
MARIA.
IT'S REALLY HARD TO FORGET THE
DEVASTATION LEFT IN THE WAKE OF
HURRICANE MARIA AND THE LIMITED
AND SLOW AID THAT MADE IT TO
HELP THE PEOPLE ON THE ISLAND.
IT'S ALL OVER THE NEWS HERE LIKE
IN CNN, ANDERSON COOPER AND IT
WOULD BE SUMMED UP IN THIS ONE
IMAGE CIRCULATING.
IT'S TAKEN BY THE FORMER
DIRECTOR OF RESEARCH ON CAYO
SANTIAGO.
AND THIS IS FROM A HELICOPTER
FLYING OVER PUNTA SANTIAGO THREE
DAYS AFTER THE STORM.
YOU CAN SEE THEY'VE WRITTEN OUT
SOS WE NEED WATER AND FOOD.
SO, DESPITE THESE EXTREMELY
DIFFICULT TIMES FOR OUR
COLLEAGUES AND THEIR FAMILIES,
THE CAYO TEAM SEM ON STRAIGHTED
RESILIENCE AND WE WORKED WITH
THEM TO RAISE TENS OF THOUSANDS
OF DOLLARS TO SEND SUPPLIES TO
THE PEOPLE OF PUNTA SANTIAGO AND
THE EQUIPMENT TO MAINTAIN THE
MACAQUES AND THEIR WELLBEING.
THESE ACTIONS AND THE FACE OF
SUCH GREAT ADVERSITY REALLY GOT
US THINKING ABOUT THE
CONSEQUENCES OF THESE DISASTERS,
THE HEALTH CONSEQUENCES AND AS
WELL AS WHAT MAKES INDIVIDUALS
MORE RESILIENT OR VULNERABLE TOO
FROM THESE NEGATIVE CONSEQUENCES
CONSEQUENCES.
THE FACT THE SAMPLES ON THE
MACAQUES A DECADE PRIOR TO
HURRICANE MARIA CAN TEST HOW A
SEVERE EVENT COULD IMPACT THE
ANIMALS WE'VE BEEN STUDYING FOR
YEARS.
HERE IS A VIDEO TAKEN TO SHOW
YOU SOME OF THE DEVASTATION ON
THE ISLAND.
FROM THAT SAME HELICOPTER RIDE
THAT ICONIC PHOTO WAS TAKEN,
WITH COMMUNICATION DOWN ALL ON
THE ISLAND IT'S HARD TO GET ON
THE GROUND INFORMATION SO THREE
DAYS AFTER THE STORM, WE FOUND A
WAY TO CHARTER A HELICOPTER AND
WE WENT FROM SAN JUAN TO PUNTA
SANTIAGO TO CHECK ON THE
RESEARCH COLONY AND OUR
COLLEAGUES AND WE HELPED ON THE
HELICOPTER AND THROUGH DOWN AND
THERE'S DRONE FOOTAGE SHOWING
YOU DEVASTATION AND THE ISLAND
IS STILL VERY MUCH RECOVERING.
NOW, DESPITE THIS EXTREME EVENT
MORTALITY WAS PRETTY LIMITED FOR
THE MACAQUES.
2.5% OF THE POPULATION DIED IN
THE FEW MONTHS AFTERWARDS.
AND THERE WAS NO DIFFERENTIAL
SURVIVAL BASED ON SEX OR AGE AND
THE YEAR AFTER THE STORM
COMPARED TO THE PRIOR 20 YEARS.
THIS IS ALIGNED WITH RECENT WORK
SHOWING NO REALLY OVER ALL
INCREASE THIS IS MORTALITY AFTER
THE PREVIOUSLY MAJOR HURRICANES
TO HIT SANTEE AGO A HUGO IN
'89 AND GEORGIA IN '98 AND
RECENTLY MARIA.
WE KNOW THAT SURVIVORS OF
EXTREME ADVERSE EVENTS LIKE
HURRICANES, HAVE INCREASED
INCIDENTS OF CARDIOVASCULAR
DISEASE AND CHRONIC LOW GRADE
INFLAMMATION AND FEATURES IN
DISEASES THAT ARE ASSOCIATED
WITH AGING.
>> YOU ARE BREAKING UP, KNO NOAH.
>> I'M SORRY.
AM I CLEAR NOW?
>> YES.
>> GREAT.
>> SO THE QUESTION WE HAVE IS,
HOW DOES A NATURAL DISASTER
INCREASE THE INCIDENTS OF SOME
OF THESE DISEASES?
AND WHAT ARE THE MOLECULAR
CONSEQUENCE AND DOES IT
ACCELERATE AGING IN SOME
INDIVIDUALS?
NOW MY GRATITUDE MARINE A. F-3 1
AWARDEE FROM NIA DREW ON HER
HISTORICAL COLLECTION FROM 2014
TO 2016 AS WELL AS PEER
RESPECTIVE DATA COLLECTED AFTER
THE HURRICANE FROM ABOUT 550
ANIMALS.
THIS IS AN OPPORTUNISTIC CROSS
SEXUASECTIONAL STUDY AND THEY WERE
MATCHED BY AGE AND SEX.
THE GOAL HERE WAS TO TEST HOW
THE HURRICANE MOL BEING YOU LAR
EFFECTED THE IMMUNE CELLS OF THE
MONKEYS SO SHE GENERATED RNA
SEQUENCING DATA FROM 550 SAMPLES
WAS A QUANTITIVE MEASURE OF ALL
THE GENES THAT ARE EXPRESSED IN
THE GIVEN TISSUE HERE AND IT
CONTAINS LUKE TOE SIGHTS AND
WHITE BLOOD CELLS AND OUR
PRIMARY RESPONDERS.
SO, FOR THE FIRST TIME, WE
IDENTIFIED AND QUANTIFY
MOLECULAR SIGNATURE OF AN
EXTREME NATURAL DISASTER IN
IMMUNE CELLS.
AND ALSO SORT OF AS EXPECTED, WE
SAW THAT THERE WERE STRONG
EFFECTS OF AGE ON GENE
EXPRESSION IN OUR PERIPHERAL
IMMUNE CELLS WITH 16% OF THE
GENES SHOWING A SIGNIFICANT
ASSOCIATION WITH CHRONOLOGICAL
AGE.
THEY WERE ASSOCIATED WITH THE
HURRICANE AND AGING.
I'LL ORIENT YOU TO THE NEXT FEW
FIGURES WHERE I HAVE THIS
DIAGRAM ON THE TOP AND I'LL SHOW
THE EXACT SIZES OF AGE AND
HURRICANE ON THE EXPRESSION OF
INDIVIDUAL GENES FOR EACH GENE
IS A SPECIFIC POINT HERE.
AND POSITIVE EFFECTS MEAN HIGHER
EXPRESSION, AND INDIVIDUAL
SAMPLED AFTER THE HURRICANE AND
OR IN TERMS OF AGE, OLDER
INDIVIDUALS.
AND I'LL KEEP THESE LITTLE LEG
OWES UP HERE.
THESE SCHEMATICS TO HELP AS WE
MOVE FORWARD.
>> SO THE BLOOD TYPES USING
MARKER GENES THAT ARE SPECIFIC
OR BIASED TOWARDS CERTAIN IMMUNE
CELL TYPES, AND WE SAW LARGELY
SIMILAR CHANGES IN AGING IN THE
EXPOSURE TO THE HURRICANE AND
WITH LOOKING MORE SIMILAR AT
LEAST AT THE GENE EXPRESSION
LEVEL TO OLDER INDIVIDUALS.
AND AGAIN, HERE EACH OF THE
POINTS REPRESENTS A SINGLE GENE
THAT WE MEASURED AND THE X VALUE
IS -- EACH OF THESE POINTS
REPRESENTS A SINGLE GENE AND THE
X VALUE IS THE EFFECT SIZE OF
THE HURRICANE AND THE Y VALUE IS
THE AGE AND ON THAT GENE
EXPRESSION, AND OVER ALL THERE
WAS A SIGNIFICANT POSITIVE
CORRELATION ACROSS ALL 7,009
GENES THAT WE MEASURED AND
BETWEEN THE TWO EFFECT SIZES.
SUCH IS THAT OLDER AGE AND POST
HURRICANE EXERTED SIMILAR
EFFECTS ON THE EXPRESSION GENES
AND FOR INSTANCE, HERE IS ONE
GONE, PROTEIN THAT SHOWS HIGHER
EXPRESSION IN OLDER MONKEYS AND
ANIMAL SAMPLED AFTER THE
HURRICANE.
THAT WAS SHOWING ALL THE GENES
AND IT'S STILL SHOWING ALL THE
GENES AND WITHOUT ANY MULTIPLY
TEST CORRECTION BUT HERE WE HAD
HAD A FALSE DISCOVERY TO
IDENTIFY GENES ASSOCIATED WITH
BIRTH AGED AND THE HURRICANE AND
WE HAD THOSE CONFIDENT ARE
ALTERED IN RESPONSE TO THE
HURRICANE OR WITH AGE, WE SEE
THAT 83% OF THEM ARE EFFECTED IN
WHAT WE WOULD SAY A SIMILAR
DIRECTION AND THIS IS STRONGLY
SIGNIFICANT, AND THEY'RE MOSTLY
UP IN THE TOP RIGHT AND THE
BOTTOM LEFT.
WHICH MEANS THAT AGING AND
HURRICANE MARIA HAVE BROADLY
SIMILAR EFFECTS ON IMMUNO CELL
GENE REGULATIONS ON THOSE CELLS
THAT ARE IMPACTED.
AND GENES IN THIS TOP-RIGHT
QUADRANT THAT INQUESTED IN INCREASED WITH
INDIVIDUALS WHO ARE OLDER.
THEY WERE BROADLY IMPLICATED IN
INCREASES IN PRO INCLINATION AND
THOSE DOWN IN THE BOTTOM LEFT
THAT DECREASED, SHOWED HIGHER
EXPRESSION IN YOUNGER MONKEYS
AND HIGHER EXPRESSION IN
INDIVIDUAL SAMPLES BEFORE THE
HURRICANE AND ASSOCIATED WITH
MAINTENANCE AND REPAIR AND
B-CELL PROLIFERATION THAT IS
KNOWN TO DECLINE WITH AGE.
WE ALSO ONE HALLMARK OF AGING
THAT WAS DISRUPTED IN OLDER
ANIMALS AND PROTEASOME TE PROTEO STAY SIS AND
THOSE WERE EXPOSED TO THE
HURRICANE.
COMPONENTS OF THE RESPONSE ARE
INVOLVED IN PROTEIN HOMEOSTASIS
AND MORE PROTEIN AGGREGATION
IMPLICATED IN THE NUMBER OF
AGE-RELATED DISEASES SO
HURRICANE-ASSOCIATED DOWN
REGULATION OF THIS RESPONSE MAY
INDICATE DISREGULATION OF
PROTEASOME YO STAY SIS NETWORKS
AND AND IT
WAS TO SEE IT IF ACCELERATE AID
GLOBAL MEASURE OF IMMUNO LOGICAL
AGING AND A INDIVIDUAL'S BODY IS
AGING AT AT SAME RATE AS THEIR
CHRONOLOGICAL AGE SO IT MATCHES
THEIR CHRONICLE AGE ON THE Y
AXIS AS THIS HEALTHY LOOKING
MONKEY HERE.
SO SOME INDIVIDUALS ARE
BIOLOGICALLY OLDER OR YOUNGER
THAN THEIR CHRONOLOGICAL AGE AND
IT CAN BE ACROSS BODILY SYSTEMS.
TO TEST THIS, IN HURRICANE
BIOLOGICAL AGE WE DRAW ON A
TRANSCRIPTIONAL AGING CLOCK
DEVELOPED IN HUMANS AND WE
LISTED OVER AND APPLIED IT TO
THE MACAQUES AND THIS IS A
TRANSCRIPTIONAL ANALOGUE TO THE
WELL-KNOWN DNA VENTILATION
CLOCKS.
MONKEYS EXPOSED TO THE HURRICANE
APPEARED TWO-YEARS-OLDER THAN
THOSE THAT DID NOT EXPERIENCE
THE HURRICANE.
THIS IS CONTROLLING FURTHER
CHRONOLOGICAL AGE.
THIS TRANSLATES TO ABOUT SEVEN
TO EIGHT YEARS IN A HUMAN
LIFESPAN.
IN SOME PRELIMINARY WORK LED BY
Dr. CASANDRA TURCOTTE, ON OUR
RO1 WE FOUND THE HURRICANE WAS
ASSOCIATED WITH REDUCED
MOBILITY, FOR A GIVEN
CHRONOLOGICAL AGE AND WE'RE
EXPAND NORTH TO OTHER DOMAINS
AND PHENOTYPES OF AGING AS PART
OF OUR BROADER RO1.
WE CAN SEE IF THEY'RE AGING
QUICKLY OR SLOWLY ACROSS THESE
DIFFERENT DOMAINS AND SOME
ANIMALS DIDN'T EXHIBIT THIS
AGING PINOT TYPE IN RESPONSE TO
THE HURRICANE AND OTHERS DID,
WHY?
SO THIS IS SOMETHING THAT WE'RE
LOOKING INTO.
AND WE THINK THAT THE SOCIAL
ENVIRONMENT PLAYS A KEY ROLE.
IN A REVIEW, MY COLLEAGUE AND I
LED WHILE I WAS DUKE THAT TURNED
INTO AN R24 GRANT THROUGH NIA
AND EVIDENCE SUPPORTING HOW A
POSITIVE SOCIAL ENVIRONMENT CAN
ACTUALLY BE PROTECTIVE OR
BUFFERING IN THE FACE OF
STRESSFUL EVENTS.
THE HURRICANE ACTUALLY DID
EFFECT SOCIAL BEHAVIOR AND PH.D
FOUND THE MACAQUES BUILT NEW
SOCIAL CONNECTIONS AFTER THE
HURRICANE AND ACTUALLY THOSE
WERE THE MOST ISOLATED BEFORE
THE HURRICANE TA BUILT THE MOST
CONNECTIONS AFTER THE HURRICANE.
AND PERHAPS THIS REFLECT SOME
SORT OF SOCIAL BUFFERING
STRATEGIES THESE INDIVIDUALS ARE
TAKING ON SO WE'RE LOOKING HOW
SOCIAL FACTORS MIGHT HAVE A
SPENCE TO THE HURRICANE.
THE IMPACT IS THE FOCUS OF THIS
RO1 THAT AIM LEADING CREDIT
Dr. BRENT AND JAMES HIGHAM AT
NYU AND HOW WE AGE ACROSS
DIFFERENT DOMAINS OF AGING
DEPICTED HERE AND I WANT YOU ALL
TO ALSO SEE THAT I'M PRACTICING
WHAT I PREACH HERE, IN TERMS OF
THE FACT THAT WE SHOULD HAVE
STRONGER AND BETTER SOCIAL
CONNECTIONS, LAUREN AND JAMES BE
TWO REALLY GOOD FRIENDS OF MINE
AND SO THAT WHEN WE ARE WORKING
ON STRESSFUL THINGS TOGETHER, WE
HAVE EACH OTHER IN SOCIAL
CONNECTIONS TO BUFFER US AND
MAYBE EXTEND OUR HEALTH SPANS A
LITTLE BIT.
A GRAD STUDENTS OF MINE FOUND
SOME IMMUNE CELL TIMES, CELLS
WHICH ACCUMULATE WITH AGE AND
ARE IMPLICATED ARE CONTEXT
DEPENDENT SUCH THAT THE AGE
EFFECTS ARE STRONGEST IN THOSE
INDIVIDUALS EXPOSED TO THE
ADVERSITY AND THOSE WOULD BE THE
LOW STATUS INDIVIDUALS HERE ON
THE RIGHT.
HE IS ALSO EXTENDING HIS PART OF
HIS SERVICE WE SUPPLEMENT TO IN
VITRO CHALLENGE AND SEQUENCING
TO QUANTIFY HOW AGE AND THE
SOCIAL ENVIRONMENT INTERACT TO
IMPACT HOW OU OUR IMMUNE RESPONSE
CAN EFFECT DIFFERENT IMMUNE
CHALLENGES.
RECENTLY KENNY AND THE GRAD
STUDENT EXTEN EXTENDED IT TO THE BRAIN
AND FOUND THAT HIGH SOCIAL
STATUS MONKEYS, SO THOSE
EXPERIENCING LOWER LEVELS OF
SOCIAL ADVERSITY HAD YOUNGER
AGES.
SO WE'RE START FOG SEE SOCIALLY
AND ENVIRONMENTALLY INDUCED
CHANGES AND MOLECULAR CHANGES
AND THAT ARE ALTERING AGES IN
THE PERIPHERY AND THE BRAIN.
IN POINTS TO THE INTERSECTION OF
SOCIAL AND THE PHYSICAL
ENVIRONMENT, BRINGING US BACK TO
RESILIENCE AND VUL NER VULNERABILITY TO
THE HURRICANE.
SO WHAT CAN WE DO ABOUT THIS
EXPOSURE TO THE HURRICANE?
HOW DO THESE THINGS TIE IN
TOGETHER AND THAT'S THE KEY OF
OUR R56 AND THE EXAMINING
EFFECTS OF THE NATURAL DISASTER
AND THE LONGER TERM CONSEQUENCE
AND WHAT PREDICTS WHO WILL BE
RESILIENT OR WHO WILL BE
VULNERABLE.
OUR RESULTS WILL HOPEFULLY
REVEAL HOW AND TO WHAT EXTENT
AND THE NATURAL DISASTER IMPACTS
AND THE AGE DECLINE WHICH WILL
INFORM THE BEHAVIOR AND
PHYSIOLOGICAL INTERVENTIONS AND
HOPEFULLY CAN REDUCE THE BURDEN
OF AGE RELATED DISEASES IN OUR
AGING POPULATION.
SO TAKING TOGETHER THIS WORK
DEMONSTRATES THAT THE EXTREME
ENVIRONMENTAL CHANGES DO
ACTUALLY INDUCE MOLECULAR
CHANGES AND COULD ACCELERATE HOW
OUR BODY AGES AND WE COMBINED
WITH OUR ON GOING WORK IN THE
SOCIAL ENVIRONMENT AND WE'RE
START TO GO IDENTIFY MECHANISMS
AND PUNE A TIVE WAYS TO
ALLEVIATE THOSE RESPONSES.
WE START AROUND THIS AGING
RESEARCH WE'RE CALLING THE CAYA
RESEARCH NETWORK AND YOU CAN SEE
ALL THE INSTITUTIONS INVOLVED
HERE LARGELY FOCUSED ON
THOUSANDSING THESE MACAQUES AS A
NATURAL MODEL FOR AGING.
WE HAVE ACTIVE ON GOING
COLLABORATIONS AND THIS IS JUST
A BLANK OF WHAT WE'VE BEEN DOING
OVER THE PAST COUPLE OF YEARS.
AND LASTLY, I WANT TO SAY WE
WERE ABLE TO HOST A 60-PERSON
IN-PERSON MEETING JUST TWO WEEKS
AGO, WITH PEOPLE FROM THE
PRIMATE RESEARCH CENTER AND ALL
THOSE INSTITUTIONS I SHOWED YOU
BEFORE, HERE IS SAY PHOTO OF US
IN ARIZONA.
AND WE GOT TO HAVE ALL THE
TRAINEES GIVE PRESENTATIONS
ABOUT THEIR ON GOING WORK AND
START TO FACILITATE AND DEVELOP
NEW COLLABORATIONS AND WE ALSO
WERE ABLE TO ROPE IN A NEW
COLLABORATOR, KALEIGH, SHOWN
HERE IN A NICE MONKEY HAT.
THIS IS THANKS TO NIA AND
NATIONAL INSTITUTES OF HEALTH
AND I WANT TO THANK EVERYONE AT
THE CRTC AND MY CLOSE
COLLABORATORS AND ALL THE
TRAINEE THAT'S HAVE BEEN
SUPPORTED BY NIA, MANY OF WHOM I
MENTIONED HERE TODAY.
>> TERRIFIC.
THANK YOU, VERY MUCH, Dr.
SNYDER-MACKLER.
QUESTIONS FOR HIM?
>> MELISSA, START US OFF.
>> I DIDN'T HAVE A QUESTION.
I WAS APPLAUDING HIS
PRESENTATION.
I ASK NOAH OFF LINE.
THANK YOU.
>> GREAT.
THANK YOU.
CHARLOTTE.
YOU HAVE A QUESTION?
>> I DO.
I DO, I WAS CURIOUS ABOUT THE
DIET AFTER THE MONKEYS AFTER THE
HURRICANE.
WHY THEY STARVING?
IF YOU WEREN'T ABLE TO FEED
THEM.
HOW MUCH YOU THOUGHT THAT MIGHT
AFFECT THERE HEALT THEIR HEATH AND SOME OF
THESE AGING MARKERS?
>> REALLY GREAT QUESTION.
THIS DIET, IT WAS HARD TO GET
BACKOUT THERE RIGHT AFTER THE
HURRICANE BUT IN THAT SORT OF A
RARE OF PICTURE YOU SAW STAFF
WITH A BAG OF MONKEY CHOW, THE
FOOD THEY ARE PROVISIONED WITH
AND THEY'RE ACTUALLY EVEN THOUGH
WE WEREN'T ABLE TO GET IN
CONTACT WITH ANYONE DOUBT THERE
AND TO THE DIRECTOR OF PRIMATE
CENTER, THAT OUTSIDE OF WASN'T
ABLE TO GET IN TOUCH OF THE TEAM
IN PUNTA SANTIAGO THEY TOOK
ROBOTS TO THE ISLAND WITH FOOD
AND FEEDING MONKEYS THE DAY
AFTER.
THE MONKEYS STILL HAD TO -- WE
HAD TO GET THEM FRESHWATER SO WE
WERE DOING A LOT OF DIFFERENT
THINGS THERE SO THIS WAS A
STRESS FOR THEM.
WE DIDN'T SEE ANY DIFFERENCES IN
THE BODY WEIGHT AT THE
INDIVIDUAL SAMPLE BEFORE AND
AFTER THE HURRICANE AS WELL SO
THAT HELPS US THINK THERE WAS A
EVENT AND LINGERING DAMAGE TO
THEIR ENVIRONMENT AND THAT HAD
LONG-TERM CONSEQUENCES.
>> SO THANK YOU FOR THAT REALLY
FANTASTIC, FASCINATING WORK.
MY QUESTION WAS REALLY CLOSE TO
WHAT CHARLOTTE ASKED, I GUESS, I
AM COULD ASK IT IN A SLIGHTLY
DIFFERENT WAY IS WHETHER IS
THERE A WAY TO DISTINGUISH LIKE
THE MAJOR TRAUMA OF LIKE OH MY
GOD THE WHOLE WORLD CHANGED,
VERSUS A SITUATION WHERE YOU
KNOW IF YOU LOOK AT THOSE TREES,
LIKE OBVIOUSLY THE VIN WAS
DEVASTATED FOR QUITE A LONG TIME
AND I AM WONDERING IF YOU HAVE
ANY COMMENTS AND IS IT POSSIBLE
THAT ANIMALS WITH A NATURAL --
THEY NATURALLY AGE FASTER OR
SOMETHING, WHAT I WANT TO SAY IF
THEY HAD A TRANSCRIPTIONAL
PROFILE THEY JUST HAPPENED TO,
HAVE A TRANSCRIPTIONAL PROFILE
MORE REFLECTIVE OF AN AGENT
ANIMAL WOULD THEY GET A LOWER
SOCIAL STATUS FROM THE BEGINNING
FROM A MORE YOUTHFUL ANIMAL.
>> THE FIRST ONE WHICH IS DIS
TIN ISSUING THE ACUTE AND
CHRONIC EFFECTS OF THE HURRICANE
AS WELL AS THE STRESSFUL, LET'S
SAY THE PSYCHOSOCIAL STRESS THAT
MIGHT BE ASSOCIATED WITH THE
EVENT, AND THE ACTUAL DAMAGE TO
THE ENVIRONMENT THAT IS STICKING
AROUND THAT'S JUST CONTINUING TO
STRESS THEM, ENVIRONMENTALLY
STRESS THEM, RIGHT, ESPECIALLY
WITH ALL THAT GREENERY KNOCKED
OFF IT'S A LOT HOTTER THERE.
I THINK THE ACUTE VERSUS CHRONIC
I THINK IT'S SOMETHING THAT
WE'RE ALWAYS TRYING TO GRAPPLE
WITH IN TERMS OF ACUTE STRESSES
EVEN IN STUDIES OF RODENTS AT
SHORT TERM VERSUS WHAT POINT
DOES IT BECOME CHRONIC SO I
DON'T KNOW IF I'M GOING TO GIVE
YOU A GOOD ANSWER THERE BUT WITH
RESPECT TO THE PHYSICAL
ENVIROMENTAL DAMAGE VERSUS THE
SCIO EMOTIONAL DAMAGE THAT MIGHT
BE GOING ON HERE, THEY'RE LINKED
AND IN HUMANS, I DON'T KNOW IF
WE NEED TO DISENTANGLE THEM AND
I DON'T KNOW IF IN HUMANS WE CAN
DISENTANGLE THEM TO IMPROVE THE
INFRASTRUCTURE SO I'M NOT SURE
HOW WE WOULD AT THIS MOMENT BUT
THIS THINGS WE THOUGHT ABOUT ARE
TRYING TO LOOK AT REFOREST
STATION AS PART OF THE ISLAND
AND SEEING IF WE CAN DISTINGUISH
THOSE TWO BUT THAT'S WHOLE
BIGGER EXPERIMENT.
THE SECOND WAS, COULD THERE NOT
REVERSE CAUSALITY HERE?
AND IN THE ANSWER IS IN THE
FEMALES, NO.
BECAUSE THE SCIO ECOLOGY OF
THESE ANIMALS NATURALLY S. THAT
THEY HAVE THESE MATERNALLY
INHERITED RANKS SO THAT FEMALES
INHERENT THE SOCIAL STATUS
ADJACENT TO THEIR MOTHERS AND
SISTERS SO IT'S RARE THEY JUMP
ABOVE ANOTHER ONE EVEN IF THEY
ARE IN LET'S SAY YOUNGER OR DROP
IF THEY'RE BIOLOGICALLY OLDER.
IN MALES, IT'S A LITTLE BIT
DIFFERENT.
SO IT COULD BE THE CASE THERE
ARE THESE CHANGES IN THOSE
ANIMALS THAT PRECIPITATE
DECLINES OR A EXPERIENCE ASSENTION AND
THEY'VE BEEN LOOKING AT IN BA TO
AN THAT HAS BABOONS.>> THERE WAS WONDERFUL AND I WAS
VERY, VERY INTERESTED IN THE
WORK SO A COUPLE QUESTIONS, ONE
IS, WHAT DO YOU KNOW ABOUT
COGNITION AND AGING IN THESE
MONKEYS AND LIKEWISE, BRAIN
CHANGES THAT MAY OR MAY NOT BE
SIMILAR TO WHAT WE SEE IN THE
AGING BRAIN AND HUMANS THAT IS
ON THE ONE AND NUMBER TWO ARE
YOU PLANNING ON DOING AUTOPSIES
WHEN THERE'S A NATURAL DEATH SO
YOU WILL HAVE -- THAT YOU CAN
WORK WITH.
>> TWO GREAT QUESTIONS.
ONE IS WE HAVEN'T PLANNED ANY
NECROPSIES IN THE PAST BUT IT'S
SOMETHING AFTER THIS WEEK
MEETING WE HAD, THAT WE ARE
GOING TO IMPLEMENT.
IT'S IMPORTANT.
THERE'S SOME LOGISTICAL ISSUES
WITH THAT BASED ON WHEN THE
ANIMALS ARE FOUND AND HOW WE
WOULD STORE THEM GET AND THEM TO
THE PROPER LOCATION TO DO THE
NECROPSY.
HOPEFULLY WE'LL EXPAND TO MORE
THEM.
COGNITION AND THE AGING BRAIN.
THERE'S A FAIR BIT OF WORK GOING
ON ON COGNITIVE CHANGES IN THESE
ANIMALS AND ALEX AT THE
UNIVERSITY OF MICHIGAN HAS BEEN
DOING SOME WORK WHERE THEY'RE
DOING IN THE FIELD COGNITIVE
TASK TO TRY AND SEE HOW
COMMISSION CHANGES OVER
DEVELOPMENT AND LIGHT O LATER ON IN LIFE
AND SHE'S PART OF OUR LARGER
COLLABORATIVE NETWORK SO WE'VE
BEEN TALKING ABOUT THAT AND LOIS
HAD MENTIONED KENNY CHIU WHO HAS
BEEN WORKING ON THE AGING BRAIN
IN THESE ANIMALS AND THE
TRANSCRIPTIONAL LEVEL ACROSS 15
DIFFERENT REGIONS THAT WE'VE
DONE SO FAR USING RNA SEQUENCING
DATA AND THEY STRONGLY
RECAPITULATE WHAT WE SEE IN
HUMANS BASED ON THE HUMAN GENE
EXPRESSION DATABASE AS WELL AND
SO WE SEE THAT THE MOLECULAR
LEVEL, THERE ARE THESE
SIGNATURES THAT ARE REALLY
ASSOCIATED WITH AGING IN HUMANS
AND ACTUALLY SIGNATURES
ASSOCIATED WITH
NEURODEGENERATIVE DISEASE AT
MOLECULAR LEVEL AND EARLIER
SIGNATURES OF THAT AT THE
EXPRESSION LEVEL.
>> IN FOLLOW-UP, I BELIEVE THEY
DON'T GET TANGLES, IS THAT
CORRECT?
>> THE JURY IS LIKE KIND OF
STILL OUT THERE AND IT'S REALLY,
REALLY LATE IN CAPTIVITY THEY DO
GET SOME OF THOSE AND THERE'S
BEEN, THEY GO TO EVIDENCE OF
DIFFERENT BACK STAGES AS WELL IN
THE MACAQUES, I HAVE A
PHENOMENAL COLLEAGUE WHO IS
MOVING HERE FROM RUSH AND HE IS
NOW AT ASU AND HE IS THE
DIRECTOR OF THE RAC.
>> I KNOW JEFF, VERY WELL, YES.
>> SO HE IS THE NEW DIRECTOR OF
OUR NEURODEGENERATIVE DISEASE
CENTER AND HE HAS BEEN WORKING
WITH THE CALIFORNIA NATIONAL
PRIMATE RESEARCH CENTER AND TO
INDUCE A D-IN THE CORTEX AND
PROGRESSED AND IT'S REALLY COOL
SO THERE ARE WAYS TO MODEL THAT
AS WELL.
>> THANK YOU.
>> ALL RIGHT.
AND WE'LL NEED TO FINISH UP
AFTER THESE QUESTIONS.
>> THANK YOU.
>> FASCINATING WORK.
THANK YOU SO MUCH.
REALLY ENJOYED IT.
TWO QUICK QUESTIONS, ONE IS THIS
CHANGES IN AGING HOW LONG IS
THAT AND CAN SOME OF THESE
TRENDS BE REVERSED WHEN TIME
GOES BY AND A SECOND QUESTION IS
ANY PLANS TO STUDY SOME
POTENTIAL INTERVENTION ON THOSE
KIND OF ANIMALS TO SEE HOW THEY
CAN BE TESTED IN THOSE DISASTER
ANIMALS?
>> FIRST QUESTION, THAT'S WHAT
WE'RE LOOKING INTO AND WE HAVE
THE R56 SO HOPEFULLY WE CAN WORK
THAT INTO THE RO1 TO TRY AND
FOLLOW THIS LONGITUDINALLY AND
SEE IF THEY'RE REVERSAL BECAUSE
IT'S A SAD STORY IF THESE
CHANGES HAPPEN AND THERE'S
NOTHING THAT CAN YOU DO ABOUT
IT, RIGHT.
SO WE'RE TRYING TO FIGURE OUT,
ARE THEY REVERSIBLE IN THESE
GROUPS AND WHAT IS IT THAT
PREDICTS WHO COMES BACK TO
BASELINE IF YOU WILL.
YOUR SECOND QUESTION, CAN WE DO
AN INTERVENTION AND I THINK AN
INTERVENTION WOULD BE FREE
RANGING WOULD BE REALLY
DIFFICULT AND IT WOULD FULLLY BE
MORE STRESSFUL FOR THEM.
AND THERE ARE ANIMALS HA ARE
PART OF A RESEARCH STATION
CALLED SAVANNAH WHICH IS ALSO
PART OF THE CARIBBEAN PRIME AT
RESEARCH CENTER OUTSIDE OF SAN
JUAN AND THOSE ANIMALS ARE
ACCESSED MORE FREQUENTLY AND
ALSO WERE EXPOSED TO SOMETHING
LIKE AND WILL ALSO LIKELY BE
EXPOSED TO FUTURE NATURAL
DISASTERS SO THAT MIGHT BE A
SCENARIO WHERE WE COULD, ONCE WE
LEARN MORE ABOUT WHAT IS GOING
ON AND PRE PREDICTS THE RESPONSE
TO RECOVERY TO TRY AND I WILL
NOTMENTO IMPLEMENTSOME INTERVENTION.
>> A BEAUTIFUL PRESENTATION.
I WAS THINKING ABOUT THE COVID
PANDEMIC AND THERE'S, AS YOU
KNOW THERE'S PERSISTENT IMMUNE
DISREGULATION AND EPI GENETIC
CHANGES AND CLUSTERING OF AGE
RELATED CONDITIONS AND PEOPLE
MIDDLE AGE AND OLDER, PEOPLE WHO
HAVE BEEN INFECTED WITH
SARS-CoV-2 VIRUS, AND THE
QUESTION I HAVE IS IS THERE
PARALLEL IN THE ANIMAL WORLD
WHERE AN DEPOSIT 'EM I CAN OF
INFECTIOUS DISEASE HAS
CLUSTERING OF AGE RELATED
CONDITIONS.
>>
>> THAT'S A GOOD QUESTION.
I UNFORTUNATELY DO THINK I CAN
GIVE A GOOD QUESTIO ANSWER TO THAT ONE
RIGHT NOW BUT CAN I LOOK INTO IT
AND GET BACK TO YOU.
>> SURE.
>> THANK YOU.
>> YEAH.
>> RICHARD, YOU WANT THE FINAL
WORD.
>> JUST A QUICK ONE.
GREAT TALK AND APOLOGIZE FOR A
TECHNICAL QUESTION BUT I
UNDERSTAND ALL OF THE ASSAYS
WERE DONE ON WHOLE BLOOD.
IS THAT CORRECT?
FOR UNDER ABLE REASONS BUT YOU
REFER TO IMMUNE SYSTEM EXCHANGES
AND I GUESS YOU CAN'T REALLY
DISTINGUISH THEM AS QUANTITIVE
CHANGES IN THE SAME CELLS OR
CONTRIBUTIONS OF ALTERED
POPULATIONS IN THE CELLS YOU
LOOK AT.
IS THAT RIGHT?
>> THAT IS CORRECT.
SOUR SAYING, YOU KNOW, WHICH I
SORT OF LOST OVER HERE BUT IN
THE PAPER WE DON'T INTO MORE
DETAIL AND IT'S ALWAYS AT THE
FRONT OF MY MIND WHEN I WORK
WITH THESE HETEROGENEOUS TISSUE
SAMPLES AND WE HAVE TISSUE
HETEROGENEITY AND THEY HAVE
DIFFERENT GENE REGULATORY
PROGRAMS SO ARE THESE CHANGES
WE'RE SEEING DUE TO CHANGES IN
CELL COMPOSITION OR ARE THEY DUE
TO CHANGES IN THE ACTUAL
REGULATORY PROGRAM SO WITHIN
SPECIFIC CELL TYPES.
WE CAN'T DO THAT WITH THE SAME
POLLS BEFORE THE HURRICANE.
WE CAN DO IT WITH SAMPLES AFTER
BECAUSE MITCHELL HAS BEEN DOING
A LOT OF FLIP CYTOMETRY THAT WE
LOOK AT THESE CHANGES WE SEE
WITH AGE SPECIFICALLY AND ALSO
WITH THE SOCIAL ENVIRONMENT AND
USING PHOTO AND SINGLE CELL
APPROACHES WE'RE TAKING THAT A
LUD US TO IDENTIFY THE
REGULATORY SIGNATURES OF
SPECIFIC CELL TYPES IN THE
HETERO GENE RUSS POPULATIO GENIUS POPULATI ON OF
CELLS SO WE CAN IDENTIFY SOME OF
THESE MARKERS THAT ARE POPPING
OUT ARE THOSE THAT ARE REALLY
INDICATIVE OF SPECIFIC SELL EYE
LAR SUB TYPES BUT YOU ARE RIGHT,
AT THAT LEVEL IT'S REALLY HARD
TO DISENTANGLE THE TWO BUT IT'S
REALLY IMPORTANT TO BE ABLE TO
DRILL DOWN AS MUCH AS WE CAN TO
REALLY IDENTIFY THE MECHANISMS
THAT ARE WORKING THERE.
>> THANK YOU, GOOD WORK.
>> THANK YOU,.
>> ALL RIGHT.
ON BEHALF OF THE NATIONAL
INSTITUTE OF AGING AND OUR
COUNCIL MEMBERS, I WANT TO THANK
YOU FOR YOUR REALLY TERRIFIC
PRESENTATION TODAY AND WISH YOU
CONTINUED SUCCESS AND
COLLABORATIONS WITH OUR
INSTITUTE.
SO, AGAIN, BEST OF LUCK AND
THANK YOU VERY MUCH FOR
PROCEDURE PRESENTATION AND
RESEARCH.
>> THANK YOU SO MUCH AND I
APOLOGIES FOR TECHNICAL
DIFFICULTIES.
>> THANK YOU, VERY MUCH.
AND OUR FINAL SPEAKER TODAY
REALLY NEEDS MONTH INTRODUCTION,
BUT I'M GOING TO TURN THIS OVER
TO Dr. HODES TO INTRODUCE OUR
NEXT SPEAKER.
>> THANK YOU, IT'S MY PLEASURE
TO INTRODUCE OUR NEXT SPEAKER,
IT WAS A VERY LUCKY DAY FOR ME,
ONE OF MY MOST PART AND YOU
DIDN'T KNOW AT THE TIME FOR ALL
OF WHEN WHEN ONE DAY 15 YEARS
AGO OR SO WE VISITED OKLAHOMA AS
ONE OF OUR OUTREACH VISITS AND I
MET MARIE BERNARD WHO THEN WE
CONVINCED TO COME TO JOIN NIA
AND FOR SOME 12 OR 13 YEARS, I
HAD THE GREAT PRIVILEGE AND YOU
HAD THE GREAT BENEFIT OF HAVING
HER AS A LEADER AT NIA AND ALL
ACROSS NIH WHERE SHE MADE HER
IMPACT ACROSS DIVERSITY ACROSS
THE LIFESPAN BY AGE AND THE
GREATER DIMENSIONS OF DIVERSITY
THAT CAME TO FOLLOW.
MARIE, AS YOU ALL KNOW, IS NOW
THE CHIEF OFFICER FOR WORKFORCE
DIVERSITY AT NIH AND SHE'S BEEN
GOOD ENOUGH TO RETURN HOME TO
THE COUNCIL AND HOME TO NIA TO
SPEAK TO US THIS AFTERNOON.
MARIE, GREAT TO HAVE YOU HERE.
>> THANK YOU, VERY MUCH, RICHARD
AND YES IT'S ALWAYS NICE TO COME
HOME AND SEE FAMILIAR FACES.
AND I'M REALLY DELIGHTED TO BE
ABLE TO SHARE WITH YOU SOME OF
THE THINGS THAT ARE HAPPENING AT
NIH WIDE IN THE DIVERSITY,
EQUITY, INCLUSION AND
ACCESSIBILITY SPACE.
SO, HOPEFULLY YOU CAN ALL SEE MY
TITLE SLIDE NOW.
>> YES.
SO OVER THE COURSE OF THE NEXT
20 TO 25 MINUTES, I'M GOING TO
TALK TO YOU ABOUT THE DIEA,
DIVERSE EQUITY INCLUSION AND
ACCESSIBILITY STRATEGIC PLAN
THAT'S BEING DEVELOPED NIH WIDE.
AND I'M GOING TO TALK BUT THINGS
COMING OUT OF MY OFFICE AS THE
CHIEF OFFICE OF THE SCIENTIFIC
WORKFORCE DIVERSITY OR THE
COSWD.
WE RELEASE AID STRATEGIC PLAN
AND SOME VERY HIGH LEVEL
HIGHLIGHTS WITH THE NIH UNITE
INITIATIVE.
SO, DEIA STRATEGIC PLAN, WHY ARE
WE DOING THIS?
BECAUSE, THERE'S REPORT LANGUAGE
IN THE BUDGET BILL FOR NIH FOR
FISCAL YEAR '21, ACTUALLY THAT
CALLED FOR THE DEVELOPMENT OF
THE DIVERSITY AND INCLUSION PLAN
THAT INCLUDES SHORT AND
LONG-TERM GOALS TO ADDRESS
RACIAL ETHNIC AND GENDER
DISPARITIES AT NIH AND THAT WAS
TO IDENTIFY AND ADDRESS BARRIERS
TO NIH FUNDING BY INVESTIGATORS
RESEARCHING HEALTH DISPARITIES
AND THE LANGUAGE CALLED THAT IT
WAS THE LAWS IN PLACE DECEMBER
OF 2020 AND IT CALLED FOR US TO
HAVE THAT PLAN WITHIN 180 DAYS
AND WE MADE THE ARGUMENT THAT
THAT'S A VERY SHORT TURN AROUND
TIME AND WE WANTED DO A GOOD,
THOROUGH JOB AND NEGOTIATED THAT
WOULD BE PROVIDED BY SPRING OR
EARLY SUMMER OF '22.
RIGHT AROUND THIS TIME.
AND THEN THERE ARE FIVE
ADMINISTRATION CAME INTO OFFICE
AND ONE HIS EXECUTIVE ORDERS
CALLED FOR THE DEVELOPMENT OF
THE DIVERSITY EQUITY INCLUSION
AND ACCESSIBILITY STRATEGIC PLAN
FOR THE FEDERAL WORKFORCE SO
THIS PLAN THAT WE'RE WORKING ON
MEETS BOTH OF THOSE NEEDS.
THERE'S A GOVERNMENT LIVE PLAN
THAT WAS RELEASED IN NOVEMBER
THAT GAVE A ROADMAP FOR
IMPLEMENTING THE EXECUTIVE ORDER
AND CHARGED ALL OF AGENCIES TO
DEVELOP A PLAN BY MARCH OF 2022
AND OUR AGENCY HHS DID DEVELOP A
PLAN RELEASED IN TIME AND WE
HAVE AN OPERATION DIVISION OF
HHS HAVE LITTLE MORE FLEXIBILITY
TO BE THOUGHTFUL AS WE DEVELOP
OUR PLAN.
OUR PLAN ARE DICTATES NIH'S
VISION FOR STRENGTHENING DEIA,
CHIV TEASE THAT THE NIH
WORKFORCE WILL UNDERTAKE TO MEET
THE VISION OF THE STRATEGIC PLAN
AND AS HARMONIZED TO THE NIH
WIDE STRATEGIC PLAN FRAMEWORK
THAT HAS ACCOMPLISHMENTS, NEEDS,
FUNDS AND CHALLENGES AND THREE
KEY AREAS.
ONE, IS HOW TO IMPLEMENT
ORGANIZATIONAL EXTRAS TO
PRIORITIZE DEIA IN THE FORK
WORSWORKFORCEIN THE NIH LEVELS AND
INSTITUTIONS FUNDED BY NIH.
AND OUR SECOND OBJECTIVE IS TO
GROW AND SUSTAIN THROUGH
STRUCTURAL AND CULTURAL CHANGE
AND BY STEWARDSHIP, PARTNERSHIPS
AND ENGAGEMENT AS COUNT ABILITY
AND CONFIDENCE AND MANAGEMENT
AND OPERATIONS VERY AKIN TO WHAT
YOU'VE SEEN WITH THE NIH WIDE
STRATEGIC PLAN AND THEN OUR
THIRD OBJECTIVE AND USUALLY WITH
THE NIH PLAN OF COURSE YOU SEE
THE RESEARCH FIRST RATHER THAN
LAST BUT BECAUSE THIS IS SO
FOCUSED UPON WORKFORCE ISSUES,
IT'S REVERSED HERE AND A THIRD
OBJECTIVE IS TO ADDRESS
WORKFORCE RESEARCH AND HEALTH
RESEARCH AND THIS IS CO-LED BY
ME AS THE COSWD AND THE DIRECTOR
OF THE OFFICE OF HUMAN
RESOURCES, THE ACTING DIRECTOR
OF EQUITY AND DIVERSITY AND
CONCLUSION AND WE HAVE 100 PLUS
PEOPLE ACROSS NIH WORKING ON
THIS WITH US AND WE HAD AN R5
THAT WAS OUT AND WE'VE HAD SOME
GOOD RESPONSES TO THAT AND WE
ARE WORKING DILIGENTLY AND WE'LL
HAVE MORE DETAILS FOR THIS
STRATEGIC PLAN AND PRESENTED AT
THE JUNIOR TENTH ADVISORY
COMMITTEE TO THE DIRECTOR
MEETING SO STAY TUNED.
AND THEN FROM THE STAND POINT OF
A COSWD, AS I SAID, WE'VE BEEN
WORKING REALLY HARD SINCE I WAS
OFFICIALLY APPOINTED AS THE
COSWD IN MAY OF 2021 AS ALLUDED
TO I WAS ACTING COSWD UNTIL
OCTOBER UNTIL THAT TIME AND AS A
RESULT, WE WERE ABLE TO HIT THE
GROUND RUNNING.
WE HAVE OUR STRATEGIC PLAN THAT
IS THE RESULT OF A LOT OF FOCUS
GROUPS AND RFRI AND TALKING TO
LOTS OF PEOPLE INSIDE AND
OUTSIDE OF NIH THAT IS
PROJECTING ACTIVITIES FOR OUR
FISCAL YEAR '22 THROUGH '26.
WHAT WE SEE, OUR VISION, IS TO
ENABLE NIH AND NIH FUNDED
INSTITUTIONS TO BENEFIT FROM THE
NATION'S FULL RANGE OF TALENT
AND WE KNOW THERE'S A LOT OF
TALENT AND WE'RE NOT TAKING
ADVANTAGE OF AND WE ALSO KNOW
THIS FOSTERS CREATIVITY AND
INNOVATION AND IT'S REALLY
ESSENTIAL THAT WE DO THAT.
OUR MISSION IS TO BE THE NIH
THOUGHT LEADER IN THE SCIENCE OF
SCIENTIFIC WORKFORCE DIVERSITY
AND USING EVIDENCE-BASED
APPROACHES TO CATALYZE CULTURES
OF INCLUSIVE EXCELLENCE.
HOW ARE WE GOING DO DO THAT?
USING NIH AS THE AT THE TIME BED
BY DES SEM NATURING THE EVIDENCE
ACROSS THE POOL BY A MEDICAL
RESEARCH ECOSYSTEM AND ACTING ON
THE EVIDENCE BY ADVANCING
INTEGRATED, INSTITUTION WIDE
SYSTEMS.
SOME EXAMPLES, JUST TO BE CLEAR,
WHEN WE TALK ABOUT DIVERSITY,
WE'RE THINKING BROADLY IN
KEEPING WITH THE NIH NOTICE OF
INTEREST AND DIVERSITY RELEASED
IN 2019 WHICH INCLUDES, IT'S
INCLUSIVE BUT INCLUDES ETHNIC
GROUPS THAT HAVE BEEN SHOWN BY
THE NATIONAL SCIENCE FOUNDATION
TO BE UNDER REPRESENTED AND
HEALTH RELATED SCIENCES ON A
NATIONAL BASIS AND INDIVIDUALS
WITH DISABILITIES AND
INDIVIDUALS FROM DISADVANTAGES
BACKGROUNDS AND THE NOTICE OF
MULTIPLE CRITERIA THAT ONE COULD
DETERMINED FROM A DISADVANTAGES
BACKGROUND.
YOU HAVE TWO OF THOSE AND WOMEN
AT THE GRADUATE LEVEL AND BEYOND
IN SCIENTIFIC FIELDS.
SO, EXAMPLES, THE EVIDENCE WE
UNVEILED SOMETHING WE CALL A 24
CENTURY SCHOLARS PROGRAM AND A
HYPOTHESIS HERE BEING THAT IF WE
CAN DEVELOP A CRITICAL MASS OF
DEI ASSAD ROA ADVOCATES THAT CAN
TRANSLATES TO THE FUNDING
ANNOUNCEMENTS ARE CONFIGURED AND
SOME DIFFERENCES IS TO WHO THE
SCIENTISTS ARE WHO MIGHT BE
OUTREACH AND WHO MAY ULTIMATELY
BE FUNDED BY NIH.
THEY ARE A GROUP OF 13
INDIVIDUALS WITH SIX MENTORS
BASICALLY AND THEY'RE GOING TO
HAVE A COMMUNITY AND THEY HAVE
TOEN CHANCE THE WORK SKILLS AND
IT'S MODELED AFTER THE VERY
SUCCESSFUL DISTINGUISHED
SCHOLARS PROGRAM THAT EXISTS IN
ASSOCIATED WITH AN INCREASE?
THE DIVERSITY OF TENURE TRACK
SCIENTISTS.
HERE WE'RE LOOKING AT
POTENTIALLY HAVING INCREASE
DIVERSITY FROM PROGRAM OFFICE
AND SCIENTIFIC REVIEW OFFICERS
AND MORE IMPORTANTLY, HOW THE
DIE VERITY IS APPLIED TO THE
EFFORT WORK OF EXTRAMURAL
PROGRAM STAFF.
AS I SAID IT'S A
SELF-REINFORCING CULTURAL OF
MENTORING AND SUPPORT FOCUSING
ON THE SCIENCE, A SCIENTIFIC
WORKFORCE DIVERSITY AND THIS IS
A LOT OF DATA OUT THERE THAT WE
NEED TO APPLY.
OUR INAUGURAL PARTICIPANT AND
COHORT LAUNCHED IN MARCH OF THIS
YEAR AND THIS IS A SIX-MONTH
EXPERIENCE AND I'M HAPPY TO NOTE
THIS NIA IS HELPING WITH THIS
AND Dr. HYMN IS ONE OF THE
MENTORS AND WE HAVE SIX MENTORS
AND 13 PARTICIPANTS AS I SAID.
IN TERMS OF DISSEMINATING THE
EVIDENCE, WE LAUNCH WILL BE
CALLED THE SCIENTIFIC WORKFORCE
DIVERSITY SEMINAR SERIES AND THE
LAST OF THE 2021-22 SEASON IS
COMING UP JUST NEXT WEEK AND
THERE'S STILL TIME TO SIGN UP IF
YOU LIKE AND IT'S GOING TO
ADDRESS THE QUESTION OF HOW THE
DIVERSITY IMPACTS SCIENCE.
AND WE'LL HAVE OPENING REMARKS
FROM Dr. ICELER FROM SCIENCE
OF POLICY AND LAUREL SMITH-DOERR
AND RICHARD FREE MAN WILL LOOK
AT DATA WITH DIVERSITY AND COVID
RESEARCH AND Dr. KUAN FROM A
GENDER PERSPECTIVE AND Dr.
SANTANGELO WILL TALK ABOUT DATA
HIS NIH GROUP LOOKED AT WITH
REGARDS TO MENTORING AND GENDER
ALIGNMENT AND Dr. SHIRLEY
TILGHMAN WILL GIVE CLOSING
REMARKS.
IT WILL BE INTERACTIVE WHERE WE
LOOK AT DATA AND WE HAVE A LOT
OF THE WAY OF Q AND A AND
INTERACTION AND IF YOU ARE
AVAILABLE, JOIN US, IF NOT, THIS
WILL BE VIDEOTAPED AND AVAILABLE
ON OUR WEBSITE AND WE'LL ALSO
HAVE PROCEEDINGS AND IT WILL BE
POSTED.
IN TERMS OF APPLYING OR ACTING
ON THE EVIDENCE, WE DEVELOPED A
NOTICE OF SPECIAL INTEREST FOR
ADMINISTRATIVE SUPPLEMENTS TO
RECOGNIZE ADMINISTRATIVE
SUPPOSEMENTS EXCELLENCE IN
DIVERSITY EQUITY AND INCLUSION
AND ACCESSIBLE AND WE WERE
AMAZED AT THE RESPONSE.
WE HAVE A THOUSAND INQUIRIES AND
WE HAD HUNDREDS OF APPLICATIONS
AND CLEARLY RECOGNIZE WHAT WE
KNOW FROM THE LITERATURING IS
MENTORING IS TO HELP VICTIMS AND
THOSE UNDER REPRESENTED TO MOVE
FORWARD IN SCIENCE AND THESE ARE
INDIVIDUALS WHO OFTEN DON'T HAVE
THOSE BUILT IN NETWORKS TO
FACILITATE THAT SORT OF THING
AND YET MENTORING IS USUALLY NOT
COMPENSATED.
SO, WE HAVE LOTS OF INQUIRIES
AND LOTS OF PEOPLE AND
PARTICULARLY SINCE ALL OF THOSE
WERE ELIGIBLE WANTED TO FIGURE
OUT HOW THEY WERE ELIGIBLE TO
APPLY FOR THOSE FUNDS AND IT'S
AAN ADMINISTRATIVE SUPPLEMENT SO
UNLESS THERE WAS A MENTORING
OBJECTIVE OR PLAN TO ENHANCE
DIVERSE PERSPECTIVES OR A
DIVERSITY SUPPLEMENT ACTIVELY
ASSOCIATED WITH THE GRANT,
PEOPLE WERE NOT ELIGIBLE.
AND THE PROCESS OF REVIEW IS ON
GOING CURRENTLY AND THE ICs
WILL PROVIDE A PRIORITIZED LIST
OF THOSE APPLICATIONS AND WE
WILL BE PRIORITIZING MENTORS WHO
WILL ENHANCE OUTREACH TO
SCIENTISTS ASK KEEPING WITH THE
ANOTHER WAY OF THINKING ABOUT IF
AS WE PRONE PRESENTED IN A NATURE
COMMENTARY LAST NOVEMBER, IT'S
LODGING ILOOKING IN THREE CONTENTS AND
INTERNAL WORKFORCE BECAUSE WE
KNOW WE NEED TO ROLE MODEL WHAT
WE EXACT OF THE EXTERNAL
BIOMEDICAL RESEARCH COMMUNITY SO
SOME HIGHLIGHTS.
FROM THE HEALTH DISPARITIES
PERSPECTIVE, AS YOU KNOW, A
MONTH AFTER UNITE WAS UNVEILED
THERE WAS AN ANNOUNCEMENT OF A
COMMON FUND INITIATIVE AND AS
OCTOBER, 11 AWARDS WERE
ANNOUNCED, FISCAL YEAR FUNDING
COMMITTING UP TO $58 MILLION
OVER FIVE YEARS AND SIX OF THOSE
WERE HEALTH EQUITY IN GENERAL
AND FIVE OF THIS WERE ON THAT
TOPIC AT MINORITY THROUGH
INSTITUTIONS AND THERE'S AN OPEN
COMPETITION FOR ADDITIONAL PLANS
FOCUSING AT MINORITY-SERVING
INSTITUTIONS THIS FISCAL YEAR
AND IT'S PROJECTED THAT FOR
FISCAL YEAR '23 THERE WILL BE A
RELEASE OF CALLED THE COMMUNITY
PARTNERSHIPS TO ADVANCE SCIENCE
FOR SOCIETY INITIATIVE OR THE
CUMPAS INITIATIVE.
THIS IS A CONCEPT THAT HAS COME
FROM NIH UNITE TO ADDRESS HEALTH
DISPARITIES AS CAN YOU SEE HAVE
BEEN ADOPTED INNS INSTITUTES AND
CENTERS.
THE GOAL SCHEER TO DEVELOP
COMMUNITY-DRIVEN HEALTH EQUITY
STRUCTURAL INTERVENTIONS AND
THUS THERE WILL BE LOCAL HEALTH
EQUITY RESEARCH ASSEMBLIES AT
EACH OF THESE FOLKS OUT HERE AND
COORDINATING CENTER WITH A
NATIONAL HEALTH EQUITY RESEARCH
IS ASSEMBLY.
PEOPLE IN THE COMMUNITY
DICTATING THEIR NEEDS TO ADDRESS
HEALTH DISPARITIES AND HEALTH
EQUITY RESEARCH HUBS FOR
SCIENTIFIC SUPPORT AND
PARTNERSHIP.
IT'S ANTICIPATED THAT THERE WILL
BE A COMMITMENT OF 23 TO
$52 MILLION A YEAR OVER THE
COURSE OF 10 YEARS AND IF YOU
ARE INTERESTED IN LEARNING MORE
ABOUT IT, I REFER TO THE
PRESENTATION WHERE IT WAS
APPROVED IN CONCEPT IN JANUARY
OF THIS YEAR.
MOVING ON TO SOME OF THE THINGS,
AGAIN, I'M JUST AT THE
50,000-FOOT LEVEL, SOME OF THE
THINGS WE'RE DOING FOR THE
INTERNAL WORKFORCE AND YOU WILL
SEE WHEN COUNCIL IS IN-PERSON OR
WHEN YOU COME TO AN IN-PERSON
MEETING AT NIH HOPEFULLY THIS
FALL.
ONE OF THEM IS SOMETHING CALLED
THE POWER OF INCLUSIVE WORKFORCE
RECOGNITION PROJECT AND IT'S THE
BRAINCHILD OF JACKSON SHOWN HERE
BOTTOM ROW SECOND FROM THE LEFT
AND SHE'S A TENURE THAT TALKS
ABOUT WALKING THROUGH THE HALLS
OF NIH AND SEEING HERSELF
REFLECTED.
AND HOW THAT LEFT HER FEELING.
AND THE GOAL OF THIS PROJECT IS
TO REFLECT EVERYONE WHO IS
IMPORTANT TO THE BIOMEDICAL
RESEARCH ENTERPRISE AND IT'S
SUCCESS.
SCIENTISTS, NON SCIENTISTS,
EARLY CAN CAREER PEOPLE, NON
EARLY CAREER PEOPLE, IT SHOWS A
VARIETY OF COLORS AND
TEXTURE TO REPRESENT THE
WORKFORCE.
THIS IS REPRESENTING WHAT'S BEEN
PUT UP IN THE BUILDING 31 OR THE
NIA EXECUTIVE OFFICES ARE
LOCATED AND THIS IS JUST OUTSIDE
MY OFFICE, I'M ON THE THIRD
THERE WERE NOW OF BUILDING ONE
TWO FLOORS UP FROM THE NIH
DIRECTOR AND THIS IS THE DISPLAY
JUST OUTSIDE OF MY DOOR THAT
SHOWS THE NIH INSTITUTE AND
CENTER DIRECTOR CURRENTLY AND I
MUST PAUSE TO GIVE FRANCIS
COLLINS CREDIT.
BECAUSE WHEN I ARRIVED AT NIH,
IN 2008, IT WAS NOT NEARLY THE
DIVERSITY THAT YOU SEE
CURRENTLY.
UNDER FRANCIS' LEADERSHIP WE
HAVE 10 WOMEN WHO ARE DIRECTORS
AND WE HAVE TWO AFRICAN
AMERICANS, TWO HISPANIC LATINOS,
THREE ASIANS AND HOWEVER WE HAVE
A LOT OF WORK TO DO BEYOND THAT
IN TERMS OF TRULY HAVING A
DIVERSE WORKFORCE.
THERE'S A LOT OF OTHER WORK
BEING DONE INTERNALLY BUT I'M
GOING TO TALK NOW ABOUT SOME OF
THE EXTERNAL WORK.
THERE'S THE RECRUITMENT FOR
SUSTAINABLE TRANSFORMATION
ANYWHERINITIATIVE.
THIS WAS BASED ON THE PROGRAM
AND THE SUCCESS OF THE PROGRAM
WITH THE IDEA OF -- AND THE
OBJECTIVE WERE TO RECRUIT
FACULTY COHORTS AND DATA SHOWS
THAT IF YOU BRING IN GROUPS OF
SCIENTISTS AS OPPOSED TO
INDIVIDUAL BUYERS YOU HAVE MORE
DIVERSITY AMONG THE GROUP AND
THE GROUP CAN BE
SELF-REINFORCING COMMUNITIES.
I WILL CLOSE WITH JUST TALKING
ABOUT A NEW UNITE INITIATIVE.
THERE'S A LOT IN BETWEEN THAT I
CAN TALK ABOUT AND THAT'S TO
DEVELOP A PRIZE FOR
INSTITUTIONAL EXCELLENCE IN DEIA
TO ACKNOWLEDGE TRANSFORMATIVE
CULTURES, SYSTEMS AND PROJECTS
AND PROCESSES THAT HAVE BEEN
DEVELOPED TO ACHIEVE INCLUSIVE
EXCELLENCE As COT COUNTRY AND ACROSS THE C OUNTRY
AND CREATED A MORE INCLUSIVE
ENVIRONMENT FOR STUDENTS AND
FACULTY.
WE HAVE AN RFI THAT IS NOW OUT
AND WE WITH APPRECIATE INPUT
FROM EVERYONE TO HELP US TO
THINK ABOUT HOW THE PRIZE SHOULD
BE STRUCTURED, WHAT SHOULD THE
OUTREACH BE?
ABOUT WHAT SHOULD THE JUDGING
CRITERIA BE?
HOW SHOULD WE SO IT'S AT THIS
GUIDE NOTICE HERE AND IT'S OPEN
UNTIL JULY 28th AND MY OFFICE
IS TAKING A LEAD ON THIS ON
BEHALF OF UNITE AND NIH.
PLEASE DO SHARE NEWS ABOUT THIS.
AS I SAID, I'M ONLY SCRATCHING
THE SURFACE HERE.
IF YOU WOULD REALLY LIKE TO KNOW
WHAT IS GOING ON, I WOULD SAY,
GO TO OUR URL AND JUST GOOGLE
NIH UNITE AND THIS WILL COME UP
IMMEDIATELY FOR YOU.
I WILL CLOSE WITH OUR FAVORITE
ADD AGE, GREAT MINDS THINK
DIFFERENTLY.
>> THANK YOU SO MUCH.
YOU KNOW, AS YOU KNOW, WE HAVE A
LOT YET TO DO BUT, I THINK
SPEAKING FOR MYSELF LOOKING BACK
OVER THIS LAST COUPLE OF YEARS
IS EXTRAORDINARY THE COMMITMENT
OF YOUR LEADERSHIP AND IN LARGE
MEASURE RESPONSIBLE AND FOR HOW
FAR WE'VE COME.
LET ME OPEN IT FOR IN PUT FROM
OUR COUNCIL.
>> TERRY.
>> YOU ARE STILL MUTED.
>> THANK YOU, THAT WAS ACTUALLY
HAND CLAPPING.
I WILL ASK MARIE A QUESTION AND
I WANT EVERYBODY TO KNOW SHE'S
THE RECIPIENT OF THE JOHN A.
HARTFORD FOUNDATION TRUSTEE
AWARD THIS COMING JUNE AND WE'RE
PROUD OF HER.
MARIE, SO, WHAT IS THE -- I
LOVED Dr. COLLINS HAS MADE
PROGRESS.
YOU MENTIONED A NUMBER OF PEOPLE
BUT HOW FAR FURTHER DO WE HAVE
TO GO?
DO YOU KNOW?
>> WE HAVE A LONG WAY TO GO.
THE DENOMINATOR AMONG THE IC
DIRECTORS AND THERE ARE 27 SO 10
OUT OF 27 ARE FEMALE BUT WHEN
YOU GO JUST BELOW THAT LAYER,
THE DIVERSITY IS MUCH, MUCH LESS
AND WE ARE WORKING DILIGENTLY IN
ADDRESSING THAT.
FIRST OFF BEING TRANSPARENT
ABOUT THE DATA.
WHEN YOU GO TO THE NIH UNITED
WEB PAGE, THERE'S A DATA BOOK
AND WE LAY IT OUT THERE FOR
EVERYONE TO SEE.
SECONDLY, TO TRY TO UNDERSTAND
WHAT THOSE BARRIERS ARE TO
PEOPLE ADVANCING AND THERE'S
BEEN SOME INTERESTING DATA IN
TERMS OF WHO GETS PUT FORWARD
FOR AWARDS HERE AT NIH AND WHAT
SORTS OF THINGS MIGHT NEED TO BE
ADDRESSED TO ALLOW GREATER
EQUITY THERE.
WE ALSO HAVE AS PART OF THE NIH
UNITE INITIATIVE, A PERFORMANCE
STANDARD FOR ALL INSTITUTE
CENTER DIRECTORS NOW AND TO
ADDRESS THE IT AND EVERY
INSTITUTE AND CENTER HAS A
RACIAL AND ETHNIC EQUITY PLAN
AND THOSE PLANS WERE SUBMITTED
APRIL 1 AND THEY HAVE BEEN
ENCOURAGED TO GO FORWARD WITH
IMPLEMENTATION AND WE ARE
CAREFULLY REVIEWING THEM AND
COMPARING THEM TO ABOUT WHAT IS
CALLED THE OFFICE OF PERSONAL
MANAGEMENT AND SECURITY MODEL
AND HOW REALLY HARD THE PEOPLE
WORK ON THAN THIS AND I WILL
TELL YOU, WHEN WE GOT ON THESE,
ALL 28 OF THEM HE SAID OH MY
GOODNESS, WHAT DID WE ASK FOR?
THE SHORTEST ONE IS 15 PAGES.
30 TO 45 PAGES.
PEOPLE REALLY LEANED INTO THIS
AND THEY REALLY THOUGHT ABOUT
THIS.
THEY STOOD BACK AND LOOKED AT
THE ENVIRONMENT AND LOOKED AT
THE DATA AND THEY THOUGHT ABOUT
WHERE THEY SEE INEQUITIES AND
THEY'RE READY TO GET WORKING ON
THAT AND THE EXPECTATION IS THIS
IS SOMETHING THAT WILL BE
REVISED AT ON AN ANNUAL BASIS
BASED ON WHAT THEY LEARN.
THEY LOOK AT THE DATA, THEY SEE
THE IMPACT OF IT AND LOOK AT
WHAT NEEDS TO BE CHANGED.
IT TAKES A WHILE TO MAKE CHANGE.
BUT THE PROCESSES TO BEGIN TO
MAKE CHANGE HAVE BEEN INITIATED.
>> VERY POWERFUL.
THANK YOU.
>> DAVID.
>> THANK YOU, RICHARD.
MARIE IT'S GREAT TO SEE YOU AND
IT'S GOOD TO SEE WHAT YOU CAN DO
WITH WHAT NIA GAVE YOU TO WORK
WITH AND IT'S REALLY IMPRESSIVE
TO SEE WHAT ARE ABLE TOLL DO
WITH ALL THE NIH IS GIVING YOU
AND YOU ARE VERY PERSUASIVE AND
CONVINCING.
WHAT I WAS WONDERING IS THE
POLITICAL SIDE OF THINGS AND THE
WILL TO SUSTAIN THEM AND PERFECT
SOLUTIONS FOR THAT AND THERE ARE
PLACES IN THE PRIVATE SECTOR
THAT ARE ALSO TRYING TO DO WELL
ON DIVERSITY ISSUES WITH THEIR
WORKFORCE AND I WONDER IF
THERE'S AN OPPORTUNITY FOR YOU
OR YOUR TEAMS TO INTERACT WITH
PRIVATE SECTOR EMPLOYERS THAT
ARE DRAWING SIMILAR KINDS OF
TRANSFORMATIONS.
>> THANK YOU, IT'S A GREAT
QUESTION AND YES, WE'VE BEEN
TALKING ACROSS GOVERNMENT AND
BEYOND IN FACT FRANCIS
INTRODUCED ME TO SEVERAL LEADERS
IN PHARMA WHO WERE INVOLVED IN
VARIOUS DAY VERSE TEE AND THE
SEMINAR IN SEPTEMBER WILL BRING
SOME OF THOSE SO, IT'S AN
EXCITING TIME AND LOTS OF PEOPLE
ARE ENERGIZED AND YOU ARE RIGHT,
POLITICS CAN SOMETIMES GET IN
THE WAY AND WHAT WE'RE TRYING TO
DO HERE THE GOAL HERE IS EQUITY
FOR ALL IT'S NOT FOCUSING ON ANY
ONE GROUP BUT LET'S DEVELOP AN
EQUITY ENVIRONMENT FOR ALL.
>> ANY ADDITIONAL QUESTIONS OR
COMMENTS?
>> I HAVE A QUESTION OR TWO
QUESTIONS ACTUALLY AND THANK YOU
MA ROW THAT WAS REALLY
IMPRESSIVE.
I HAVE TWO ONE IS SPEAKING ABOUT
SUSTAINABILITY AND THIS MIGHT BE
THE SECOND IN IMPORTANCE PART OF
MY QUESTION BUT SOME OF THESE
AMAZING INITIATIVES LIKE THE
FIRST AWARDS LIKE THE R25 AWARDS
AND THAT ARE THROUGHOUT THE
INSTITUTION AND LIKE THE
ALZHEIMER'S DISEASE RESOURCE
CENTERS FOR MINORITY AGING
RESEARCH AND FOCUS ON FUNDING
FOR SCIENTISTS WHO ARE FROM
BACKGROUNDS THAT ARE UNDER
REPRESENT AND HAVE NOT BEEN
INCLUDED TRADITIONALLY IN THE
ACTIVITIES BUT THEY, I THINK, AS
A GROUP, MAY BE UNDERFUNDED AND
PART OF THAT, I SPEAK ABOUT THAT
FROM AN INSTITUTION THAT WAS
LOOKING INTO AND HOPING TO
REAPPLY FOR A FIRST AWARD AND I
THINK THAT THE INCENTIVES ARE
REALLY DIFFERING ACROSS
INSTITUTIONS FOR THAT AWARD SO,
IS THERE MORE MONEY COMING TO
THOSE AND THEN SECONDLY, IT'S A
CONCERN OF THIS COUNCIL
CONTINUING TO BE A CONCERN AND
THE DISPARITY IN AWARDS GOING TO
BLACK SCIENTISTS, BLACK AND
LATINO SCIENTISTS.
SO, THERE IS A -- I WANTED TO
GET YOUR THOUGHTS ONSET ASIDE
FUNDING AND ADDITIONAL SET ASIDE
FUNDING THROUGHOUT THE
INSTITUTION FOR PEOPLE WHO ARE
COMING FROM THESE BACKGROUNDS,
PARTICULARLY FOR RO1 FUNDING AND
HOW THAT CAN BE MOVED FORWARD,
YOU KNOW, IN A WAY THAT WILL
CLOSE THAT REALLY IMPORTANT GAP
THAT WE HAVE AT NIH.
>> I'LL GO WITH THE LAST
QUESTION FIRST AND TALK ABOUT
THE FIRST.
WE DO HAVE DATA THAT SUGGESTS
THAT WE MAY BE MAKING IN
PROGRESS IN CLOSING THOSE GAPS
AND IN FACT, I JUST GOT THROUGH
SENDING THE MANUSCRIPT TO
JOURNAL EDITOR AND I HOPE THAT
WE WILL GET A POSITIVE RESPONSE
SO WE CAN GO AND HAVE A SIDE
ABLE OBJECT.
IT'S NOT CLOSED YET BUT WE'RE
MAKING PROGRESS AND WHY?
WHAT SPECIFIC PROGRAMS ACCOUNT
FOR THIS CANNOT SAY AT THIS
POINT.
WE NEED TO DO A LOT MORE IN THE
WAY OF ANALYSIS BUT JUST WANTED
PUT IT OUT THERE THAT THINGS ARE
MOVING.
NOT NECESSARILY AS QUICKLY AS
WE'D LIKE BUT THINGS ARE MOVING.
ONE OF THE BIG BARRIERS WE HAVE
IS WE ARE FOCUSING ON PARTICULAR
GROUPS AND THAT IS THE REASON
THAT YOU WILL SEE US AND I TOOK
OUT MY LIED AND THE PLANS TO
ENHANCE DI WIDE PERSPECTIVE AND A
WAY OF TRYING TO MAKE SURE THAT
YOU HAD MORE DIVERSITY ON
SCIENTISTS AND IT'S THAT YOU
HAVE TO HAVE A PLAN TO ENHANCE
THE PERSPECTIVES AMONG THE
SCIENTIFIC AND THE PERSPECTIVES
BY GEOGRAPHY AND DISCIPLINE AND
KEEPING WITH NIH.
THAT PASS IS MUSTER ACCORDING TO
OUR OFFICE OF GENERAL COUNCIL
AND THAT IS ENCOURAGING MULTIPLE
ASSISTED CENTERS TO USE THAT
LANGUAGE IN OTHER FOAs AND I
KNOW NIGMS IS BEING AGGRESSIVE
ALONG THOSE LINES AND WE NEED TO
CONTINUE TO THINK ABOUT HOW WE
CAN TAKE ADVANTAGE OF CURRENT
LAW TO ALLOW US TO MAKE THAT
SAME SORT OF OUTREACH AND THERE
ARE 80 PLUS PEOPLE IN THE UNITE
INITIATIVE AND 500 PEOPLE IN THE
ANTIRACISM STEERING COMMITTEE
AND OTHERS WHO ARE REALLY
LEANING IN AND THINKING ABOUT
HOW WE MAKE THAT LAP.
I WILL ADMIT I'M A LITTLE
NERVOUS ABOUT WHAT WILL HAPPEN
AND THE DEGREES OF FREEDOM WE
HAVE AT THE END OF THE NEXT
SUPREME COURT SEASON WHEN THE
CASE GOES THROUGH BUT RIGHT NOW,
WE ARE DOING WITH WHAT WE
UNDERSTAND TO BE OUR LEGAL
ABILITIES.
I WILL ALSO SAY THE UNITE
INITIATIVE IS VERY SPECIFICALLY
SENSITIVE TO THE ISSUES OF
MINORITY SERVING INSTITUTIONS,
HBCU, TRIBAL SERVING INSTITUTION
AND WHAT CAN HELP THOSE
INSTITUTIONS.
SO THOSE ARE THAT SIDE THAT
WOULD BE MY RESPONSE THERE.
WITH REGARDS TO THE FIRST, YES,
FIRST IS ANOTHER EXPERIMENT TO
SEE WHAT WE'VE SEEN IN THE
SCHOLARS PROGRAM CAN BE REAP LA
REPLICATED OUTSIDE AND NONE THE
LESS, ANOTHER UNITE INITIATIVE
THAT GOT APPROVED IN CONCEPT AT
THE DECEMBER 10th ADVISORY
COMMITTEE MEETING IS I CALL IT
FIRST LIGHT.
POTENTIALLY A FUNDING
OPPORTUNITY ANNOUNCEMENT THAT
WOULD GIVE FUNDS TO INSTITUTION
TO ASSESS THEIR ENVIRONMENT AND
MAKE CHANGES TO MAKE THEM MORE
INCLUSIVE AND SUPPORTIVE SO
WE'LL HOPEFULLY SEEING A FOA
COMING UP ON THAT SOME TIME
SOON.
>> THANK YOU, MARIE.
THANK YOU FOR HANGING IN WITH US
AND ALL OF THOSE WHO ARE STILL
ON.
ARE THERE ANYMORE QUESTIONS?
CAN WE HEAR THEM.
IF NO, MARIE, MORE THANKS THAN
WORDS WE CONVEY FOR ALL THAT
YOU'VE DONE FOR NIA AND NIH AND
THE FIELD AND FOR THE WORLD AND
WE LOOK FORWARD TO TALKING.
WE'LL BE SUN OR THE TIVE AND
PROUD TO BE WORKING WITH YOU.
>> THANK YOU TO MY NIA FAMILY IT
WOULD NEVER BE POSSIBLE WITHOUT
YOUR SUPPORT.
THANK YOU.
>> KEN, THANK YOU.
>> ALL RIGHT.
>> WELL, AGAIN, I EXTEND MY
THANKS, MARIE AND AMAZING TALK.
REALLY WONDERFUL TO JUST TO HEAR
ALL THE REAL TANGIBLE
COMMITMENTS AT NIH IS MAKING
RIGHT NOW SO, REALLY WELL DONE
AND WE ARE REALLY LOOKING
FORWARD TO MORE INITIATIVES TO
COME OUT AND OUR OWN
PARTNERSHIPS WITH YOU.
SO, I GUESS WITH THAT SAID, I
THANK YOU ALL FOR BEARING WITH
US FOR THE OVERTIME.
IT WAS WELL WORTH IT, I WOULD
SAY.
AND AGAIN, THIS CONCLUDES OUR
COUNCIL MEETING FOR THE NATIONAL
ADVISORY COUNCIL ON AGING.
SO, I WISH YOU ALL WELL AND HAVE
A GREAT REST OF THE AFTERNOON.
THANK YOU.
>> THANK YOU.