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>>WELCOME EVERYONE TO THE

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NATIONAL ADVISORY COUNCIL ON

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AGING.

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WE WILL BE -- I JUST HAVE A FEW

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HOUSEKEEPING ITEMS.

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SESSION IS BEING RECORDED, FIRST

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00:00:23,280 --> 00:00:24,680
OFF.

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>> RECORDING IN PROGRESS.

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>> AND VIDEOCAST TO THE GENERAL

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PUBLIC.

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SO, JUST TO KEEP THAT IN MIND.

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AND I BELIEVE THAT'S ALL WE HAVE

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TO REPORT AT THE MOMENT.

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I'LL TURN IT OVER TO DR. HODES.

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RICHARD?

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>>  THANK YOU, KEN.

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WELCOME.

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THIS IS WHERE I WALK UP TO THE

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PODIUM.

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00:00:45,200 --> 00:00:46,560
AND THE SLIDES COME UP.

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I'LL GIVE YOU A BRIEF

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00:00:48,600 --> 00:00:49,160
BACKGROUND.

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00:00:49,160 --> 00:00:50,480
YOU'LL SEE IN ADDITION TO THE

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00:00:50,480 --> 00:00:52,000
STATUS REPORT OF WHAT'S NEW,

25
00:00:52,000 --> 00:00:53,080
THIS TIME BECAUSE THERE'S SO

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00:00:53,080 --> 00:00:55,640
MANY STAFF WHO HAVE COME ON, WE

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00:00:55,640 --> 00:00:58,440
HAVEN'T HAD A CHANCE TO

28
00:00:58,440 --> 00:01:00,080
INTRODUCE THEM IN PERSON.

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00:01:00,080 --> 00:01:01,520
ONCE I'VE GONE THROUGH A FEW

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ITEMS OF BACKGROUND, WE'LL HAVE

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00:01:03,960 --> 00:01:04,640
DIVISION DIRECTORS INTRODUCE TO

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00:01:04,640 --> 00:01:06,360
YOU SOME OF THE STAFF WHO HAVE

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00:01:06,360 --> 00:01:13,640
COME ON IN THE PAST YEARS. 

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00:01:13,640 --> 00:01:14,640
NEXT SLIDE PLEASE.

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00:01:14,640 --> 00:01:16,160
ALWAYS AN IMPORTANT ISSUE AND

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00:01:16,160 --> 00:01:18,680
ALWAYS IN JANUARY, WE'RE IN THE

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00:01:18,680 --> 00:01:20,240
SAME SITUATION OF NOT HAVING AN

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00:01:20,240 --> 00:01:22,920
APPROPRIATION FOR THE CURRENT

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00:01:22,920 --> 00:01:23,920
YEAR, IN THIS CASE FY2022.

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00:01:23,920 --> 00:01:26,680
THIS IS A SUMMARY OF WHERE WE

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00:01:26,680 --> 00:01:26,880
STAND.

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00:01:26,880 --> 00:01:29,640
BACK IN JULY, THE HOUSE PASSED

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00:01:29,640 --> 00:01:33,440
ITS APPROPRIATIONS BILL. 

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00:01:33,440 --> 00:01:34,280
IT CALLED FOR NEARLY

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00:01:34,280 --> 00:01:36,720
$49.4 BILLION OVERALL FOR ALL OF

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00:01:36,720 --> 00:01:37,080
NIH.

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00:01:37,080 --> 00:01:43,080
$3 BILLION FOR THE NEW ARPA-H.

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00:01:43,080 --> 00:01:47,440
UNDER THIS LANGUAGE, NIA 

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00:01:47,440 --> 00:01:52,800
APPROPRIATION WOULD INCREASE TO

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00:01:52,800 --> 00:02:07,080
$4.3258 BILLION, $200 MILLION

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00:02:07,080 --> 00:02:11,280
FOR ADRD. 

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00:02:11,280 --> 00:02:14,440
HERE ARPA IS LOWER, NIA TOTAL IS

53
00:02:14,440 --> 00:02:17,920
LOWER, HERE THE NUMBERS, $235

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00:02:17,920 --> 00:02:18,800
MILLION FOR ADRD RESEARCH, $29

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MILLION FOR RESEARCH ON OPIOIDS

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00:02:19,880 --> 00:02:20,440
AND PAIN.

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00:02:20,440 --> 00:02:23,080
AS MANY OF YOU WILL KNOW, THE

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00:02:23,080 --> 00:02:25,360
GOVERNMENT IS CURRENTLY

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00:02:25,360 --> 00:02:30,560
FUNCTIONING UNDER A CONTINUING

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RESOLUTION TILL FEBRUARY 18 AND

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00:02:32,600 --> 00:02:34,440
HOPE WE HAVE APPROPRIATION.

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ALTERNATIVE IS CONTINUED FURTHER

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RESOLUTION.

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00:02:36,520 --> 00:02:37,400
UNDER THE CIRCUMSTANCES, WE'RE

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FORCED TO BE CONSERVATIVE AND

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00:02:40,480 --> 00:02:43,680
FUNDING LINES, THE DIFFERENCE IS

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INCREASE $200 MILLION-PLUS FOR

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00:02:45,120 --> 00:02:46,800
THE YEAR WILL MAKE A SUBSTANTIAL

69
00:02:46,800 --> 00:02:51,080
DIFFERENCE IN FUNDS AVAILABLE

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00:02:51,080 --> 00:02:54,200
FOR GRANTS AND OTHER MECHANISMS.

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00:02:54,200 --> 00:02:55,080
WITH THESE CONSERVATIVE INTERIM

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00:02:55,080 --> 00:02:57,840
PAYLINES YOU'LL SEE FOR THE

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00:02:57,840 --> 00:02:59,600
GENERAL PAYLINE, IT'S NOT ADRD,

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00:02:59,600 --> 00:03:02,560
FOR THE MOST COMMON APPLICATIONS

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00:03:02,560 --> 00:03:08,040
UNDER $500,000, THE PAYLINE AT

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00:03:08,040 --> 00:03:09,280
THE EIGHTH PERCENTILE AND HOPING

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FOR INCREASE BUT THIS IS THE

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00:03:13,000 --> 00:03:13,240
INTERIM.

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00:03:13,240 --> 00:03:15,720
WE GIVE ADVANTAGE TO NEW AND

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00:03:15,720 --> 00:03:17,360
EARLY-STAGE INVESTIGATORS, AT

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THE 11th AND 13th

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PERCENTILE, AS AS WE'VE BEEN

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00:03:20,520 --> 00:03:22,080
DOING FOR SOME YEARS HAVE HIGHER

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00:03:22,080 --> 00:03:24,840
BAR FOR FUNDING OF MORE

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00:03:24,840 --> 00:03:30,560
EXPENSIVE OVER $500,000

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00:03:30,560 --> 00:03:30,880
APPLICATIONS.

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00:03:30,880 --> 00:03:33,480
FOR AD ADRD, THE CIRCUMSTANCE IS

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00:03:33,480 --> 00:03:34,560
BETTER.

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00:03:34,560 --> 00:03:35,960
INTERIM PAYLINES 25th

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00:03:35,960 --> 00:03:38,480
PERCENTILE, WITH 28th AND 30,

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00:03:38,480 --> 00:03:39,680
RESPECTIVELY, FOR NEW AND

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00:03:39,680 --> 00:03:42,840
EARLY-STAGE INVESTIGATORS.

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00:03:42,840 --> 00:03:47,480
NEXT SLIDE PLEASE. 

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00:03:47,480 --> 00:03:49,200
SIMILAR PAYLINES FOR

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00:03:49,200 --> 00:03:50,920
NON-PERCENTILED APPLICATIONS, A

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00:03:50,920 --> 00:03:52,680
SUBSTANTIAL DIFFERENCE BETWEEN

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00:03:52,680 --> 00:03:57,320
AD/ADRD, PAY LINES FOR PROGRAM

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00:03:57,320 --> 00:03:58,400
PROJECTS, 37, CAREER DEVELOPMENT

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00:03:58,400 --> 00:04:01,360
AT 28, BUT FOR GENERAL LINE

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00:04:01,360 --> 00:04:02,120
SUBSTANTIALLY LOWER, 13th

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00:04:02,120 --> 00:04:03,320
PERCENTILE FOR PROGRAM PROJECTS

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00:04:03,320 --> 00:04:09,480
AND OTHER NIA REVIEWED, 25th

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00:04:09,480 --> 00:04:12,480
FOR FELLOWSHIPS, WE MAKE EFFORT

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00:04:12,480 --> 00:04:13,680
EVEN UNDER INTERIM CONDITIONS,

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00:04:13,680 --> 00:04:15,520
RECOGNIZE THE IMPORTANCE OF OUR

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00:04:15,520 --> 00:04:20,040
EARLY CAREER FELLOWSHIP AND

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00:04:20,040 --> 00:04:23,480
CAREER DEVELOPMENT CATEGORIES.

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00:04:23,480 --> 00:04:24,080
SOME UPDATES.

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00:04:24,080 --> 00:04:28,080
I WANTED TO SHARE WITH YOU IN

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00:04:28,080 --> 00:04:30,080
THE AREA OF ALZHEIMER'S-RELATED

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00:04:30,080 --> 00:04:33,000
DEMENTIA, THIS UPDATED AS OF

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00:04:33,000 --> 00:04:34,480
SOME 365 TRIALS IN ALL THESE

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00:04:34,480 --> 00:04:38,920
CATEGORIES YOU CAN SEE. 

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00:04:38,920 --> 00:04:41,000
72 TRIALS PHARMACOLOGIC

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00:04:41,000 --> 00:04:41,400
INTERVENTION, 120

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NON-PHARMACOLOGIC, 155 DEMENTIA

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00:04:42,240 --> 00:04:42,760
CARE AND CAREGIVING.

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00:04:42,760 --> 00:04:44,880
IF YOU LOOK AT WHAT IS LISTED

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00:04:44,880 --> 00:04:46,920
UNDER THESE CATEGORIES, FOR

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00:04:46,920 --> 00:04:48,800
EXAMPLE, IN THE PHARMACOLOGIC

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00:04:48,800 --> 00:04:50,880
INTERVENTIONS NOTABLY EARLY

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STAGE TRIALS, THE VARIETY OF

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00:04:53,720 --> 00:04:54,600
TARGETS ILLUSTRATING THE

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00:04:54,600 --> 00:04:57,520
COMMITMENT AND SUCCESS IN

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00:04:57,520 --> 00:04:59,200
FUNDING INNOVATIVE APPLICATIONS

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THAT TARGET MOST POTENTIAL

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00:05:01,280 --> 00:05:04,800
COMPONENTS OF ALZHEIMER'S AND

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00:05:04,800 --> 00:05:05,760
RELATED DEMENTIAS DISEASE

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00:05:05,760 --> 00:05:06,880
PROCESSES.

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00:05:06,880 --> 00:05:08,800
IN TERMS OF COVID-RELATED

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00:05:08,800 --> 00:05:11,520
OPPORTUNITIES HERE WITH NIA

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00:05:11,520 --> 00:05:14,080
PARTICIPATION CURRENTLY ACTIVE,

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00:05:14,080 --> 00:05:15,880
ONE IN NEUROLOGIC SEQUELAE FROM

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SARS, WE'LL HEAR LET ABOUT

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00:05:20,160 --> 00:05:21,560
LONG-TERM SEQUELAE OF COVID, AND

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00:05:21,560 --> 00:05:24,320
PROJECTS THAT ARE UNDERWAY TO

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00:05:24,320 --> 00:05:26,960
ADDRESS THESE WITH NIA

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00:05:26,960 --> 00:05:28,160
INVOLVEMENT.

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00:05:28,160 --> 00:05:29,520
ANOTHER ON SOCIAL, BEHAVIORAL,

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00:05:29,520 --> 00:05:31,520
ECONOMIC IMPACT OF COVID-19 IN

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00:05:31,520 --> 00:05:32,760
UNDERSERVED AND VULNERABLE

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00:05:32,760 --> 00:05:34,840
POPULATIONS PARTICULARLY.

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00:05:34,840 --> 00:05:36,040
NEXT PLEASE.

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00:05:36,040 --> 00:05:42,800
JUST A COUPLE OF NOTABLE

145
00:05:42,800 --> 00:05:44,360
RELEASES HERE, NASEM DECADAL

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00:05:44,360 --> 00:05:45,880
SURVEY, LOOKING AT EFFORTS TO

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00:05:45,880 --> 00:05:49,120
REDUCE THE IMPACT OF DEMENTIA IN

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00:05:49,120 --> 00:05:51,080
AMERICA, SURVEY OF BIOBEHAVIORAL

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00:05:51,080 --> 00:05:52,320
AND SOCIAL SCIENCES,

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00:05:52,320 --> 00:05:53,920
RECOMMENDING THIS TO YOU.

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00:05:53,920 --> 00:05:55,680
LOOKS FOR EMPHASIS ON NOT JUST

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00:05:55,680 --> 00:05:58,000
IDENTIFYING CAUSES BUT SOLUTIONS

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00:05:58,000 --> 00:06:01,720
FOR DISPARITIES.

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00:06:01,720 --> 00:06:02,480
NEXT PLEASE.

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00:06:02,480 --> 00:06:04,240
IN COLLABORATION WITH OTHER

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00:06:04,240 --> 00:06:05,880
AGENCIES, OUR EXTENSIVE AND

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00:06:05,880 --> 00:06:09,080
CONTINUING NOTABLY WITH THE V.A.

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00:06:09,080 --> 00:06:10,840
FOCUSING ON RECRUITMENT OF

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00:06:10,840 --> 00:06:12,600
VETERANS INTO ALZHEIMER'S

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00:06:12,600 --> 00:06:13,360
DISEASE RESEARCH BECAUSE THE

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00:06:13,360 --> 00:06:14,480
IMPORTANCE OF THE POPULATION,

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00:06:14,480 --> 00:06:16,520
GIVEN THE VERY LARGE MEDICAL

163
00:06:16,520 --> 00:06:18,480
CARE SERVICES POPULATION UNDER

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00:06:18,480 --> 00:06:21,120
V.A. AEGIS, AN OPPORTUNITY TO

165
00:06:21,120 --> 00:06:22,440
INCREASE DIVERSITY OF STUDIES,

166
00:06:22,440 --> 00:06:23,720
SUCCESSFUL SO FAR ESTABLISHING

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00:06:23,720 --> 00:06:24,640
THESE COLLABORATIONS WITH MORE

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00:06:24,640 --> 00:06:27,360
TO COME.

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00:06:27,360 --> 00:06:28,520
NEXT PLEASE.

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00:06:28,520 --> 00:06:30,520
AND EACH YEAR I WANT TO REMIND

171
00:06:30,520 --> 00:06:33,040
YOU OF THE BUTLER-WILLIAMS

172
00:06:33,040 --> 00:06:33,960
COLLEGE PROGRAM, OUTSTANDING

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00:06:33,960 --> 00:06:36,440
MULTI-DAY PROGRAM, ONCE AGAIN TO

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00:06:36,440 --> 00:06:38,640
BE HELD VIRTUALLY THIS SUMMER

175
00:06:38,640 --> 00:06:40,280
2022, APPLICATION DEADLINE

176
00:06:40,280 --> 00:06:41,080
SPRING OF 2022, BRINGING

177
00:06:41,080 --> 00:06:44,680
TOGETHER PEOPLE AT EARLY STAGES

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00:06:44,680 --> 00:06:46,480
OF THEIR CAREER, TO DISCUSS THE

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00:06:46,480 --> 00:06:48,240
BREADTH OF AGING RESEARCH WITH

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00:06:48,240 --> 00:06:50,000
STRONG EMPHASIS ON HEALTH

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00:06:50,000 --> 00:06:52,600
DISPARITIES RESEARCH.

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00:06:52,600 --> 00:06:53,800
NEXT PLEASE.

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00:06:53,800 --> 00:06:55,520
HAPPY TO NOTE THAT

184
00:06:55,520 --> 00:06:56,520
ALZHEIMER'S.GOV, YOU MAY

185
00:06:56,520 --> 00:07:00,280
UNDERSTAND TO BE THE DESTINATION

186
00:07:00,280 --> 00:07:06,840
FOR DEMENTIA RESOURCE TO BROAD 

187
00:07:06,840 --> 00:07:08,640
POPULATIONS IS FULLY AVAILABLE.

188
00:07:08,640 --> 00:07:14,080
FULLY AVAILABLE IN SPANISH AND

189
00:07:14,080 --> 00:07:17,200
WORKING ON OTHER LANGUAGES.

190
00:07:17,200 --> 00:07:19,360
TO ILLUSTRATE EFFORTS

191
00:07:19,360 --> 00:07:20,800
DISSEMINATING INFORMATION, IN

192
00:07:20,800 --> 00:07:27,520
PERSON MEETINGS, WE WOULD PASS

193
00:07:27,520 --> 00:07:29,640
AROUND A BOOK, RESEARCH

194
00:07:29,640 --> 00:07:30,080
HIGHLIGHTS, BLOGS,

195
00:07:30,080 --> 00:07:32,040
ANNOUNCEMENTS, SUMMARY OF THE

196
00:07:32,040 --> 00:07:33,480
OPPORTUNITIES WE'VE HAD TO

197
00:07:33,480 --> 00:07:34,680
DISCUSS WITH STAKEHOLDERS AND

198
00:07:34,680 --> 00:07:35,760
CONGRESSIONAL BRIEFINGS OVER THE

199
00:07:35,760 --> 00:07:39,120
PAST MONTHS.

200
00:07:39,120 --> 00:07:42,320
NEXT PLEASE.

201
00:07:42,320 --> 00:07:46,960
NIH UPDATES, ONE, COMMON FUND

202
00:07:46,960 --> 00:07:48,800
INITIATIVE, VERY RELEVANT TO

203
00:07:48,800 --> 00:07:51,600
NIA, SEPARATE APPROPRIATION FROM

204
00:07:51,600 --> 00:07:53,360
CONGRESS, OVER $500 MILLION, AND

205
00:07:53,360 --> 00:07:54,680
IT IS TARGETING RESEARCH THAT

206
00:07:54,680 --> 00:07:57,000
SPANS THE INTEREST OF MULTIPLE

207
00:07:57,000 --> 00:07:58,960
INSTITUTES AND CENTERS, BROAD

208
00:07:58,960 --> 00:08:01,080
AND BOLD, HAS GOALS, AND ONE

209
00:08:01,080 --> 00:08:05,440
THAT'S BEEN SPONSORED BY NIA,

210
00:08:05,440 --> 00:08:07,600
WITH NCI, CELLULAR SENESCENCE

211
00:08:07,600 --> 00:08:09,320
NETWORKS, ONE OF THE MECHANISMS

212
00:08:09,320 --> 00:08:11,920
WHICH HAS A STRONG RELEVANCE TO

213
00:08:11,920 --> 00:08:13,560
AGING, AGING PROCESSES, SO

214
00:08:13,560 --> 00:08:15,120
AWARDS HAVE BEEN MADE TO A

215
00:08:15,120 --> 00:08:19,680
VARIETY OF SITES THAT ARE

216
00:08:19,680 --> 00:08:20,280
STUDYING CELLULAR SENESCENCE

217
00:08:20,280 --> 00:08:21,240
ESTABLISHING OVER MULTIPLE

218
00:08:21,240 --> 00:08:24,080
TISSUES IN HUMANS, AND NOW A

219
00:08:24,080 --> 00:08:25,160
RELEASE, SOLICITATION FOR

220
00:08:25,160 --> 00:08:27,280
APPLICATIONS TO DO SIMILAR IN

221
00:08:27,280 --> 00:08:28,880
MOUSE, THE NOTION BEING

222
00:08:28,880 --> 00:08:31,080
CROSS-TALK BETWEEN HUMANS ANDS

223
00:08:31,080 --> 00:08:32,400
INTERVENTIONS IN A MOUSE MODEL

224
00:08:32,400 --> 00:08:35,000
WILL BE EXTENSIVE SO A WAY WE'VE

225
00:08:35,000 --> 00:08:36,520
LEVERAGED ACROSS ALL OF NIH OF

226
00:08:36,520 --> 00:08:38,760
ONE OF THE MAJOR ASPECTS OF

227
00:08:38,760 --> 00:08:42,120
BASIC BIOLOGY OF AGING SUPPORTED

228
00:08:42,120 --> 00:08:46,720
HERE AT NIA. 

229
00:08:46,720 --> 00:08:48,480
NEXT PLEASE.

230
00:08:48,480 --> 00:08:51,440
AD ADRD SUMMIT COMING UP, THEMES

231
00:08:51,440 --> 00:08:52,560
OF ALZHEIMER'S, RELATED

232
00:08:52,560 --> 00:08:55,080
DEMENTIAS, A SERIES OF THREE

233
00:08:55,080 --> 00:08:57,120
SUMMITS, THE ALZHEIMER'S

234
00:08:57,120 --> 00:08:58,560
RESEARCH SUMMIT, AD/ADRD SUMMIT

235
00:08:58,560 --> 00:09:00,840
ON CARE AND SERVICES, THIS IS

236
00:09:00,840 --> 00:09:04,040
THE ADRD SUMMIT, WILL BE

237
00:09:04,040 --> 00:09:08,600
ORGANIZED BY NINDS WORKING WITH

238
00:09:08,600 --> 00:09:10,120
NIA, ROD CORRIVEAU TAKING THE

239
00:09:10,120 --> 00:09:12,680
LEAD, ENCOURAGING YOU TO SIGN ON

240
00:09:12,680 --> 00:09:13,640
AND REGISTER.

241
00:09:13,640 --> 00:09:17,480
THIS WILL BE FULLY VIRTUAL IN

242
00:09:17,480 --> 00:09:25,200
LIGHT OF THE CONTINUING PANDEMIC

243
00:09:25,200 --> 00:09:25,480
CONSTRAINTS.

244
00:09:25,480 --> 00:09:30,480
NEXT PLEASE. 

245
00:09:30,480 --> 00:09:32,120
A MAJOR EVENT, ANNOUNCEMENT THAT

246
00:09:32,120 --> 00:09:34,880
FRANCIS COLLINS STEPPED DOWN.

247
00:09:34,880 --> 00:09:36,480
LARRY TABAK, LONG-TERM DEPUTY

248
00:09:36,480 --> 00:09:39,680
DIRECTOR IS ACTING DIRECTOR NOW.

249
00:09:39,680 --> 00:09:40,840
THIS MEANS REASSURINGLY TO ALL

250
00:09:40,840 --> 00:09:43,600
OF US NIH IS FUNCTIONING AND

251
00:09:43,600 --> 00:09:44,680
FUNCTIONING WELL WHILE WE AWAIT

252
00:09:44,680 --> 00:09:46,560
THE PROCESS FROM THE WHITE HOUSE

253
00:09:46,560 --> 00:09:48,480
IN APPOINTING OR NOMINATING THE

254
00:09:48,480 --> 00:09:51,560
NEXT DIRECTOR OF NIH.

255
00:09:51,560 --> 00:09:52,000
NEXT PLEASE.

256
00:09:52,000 --> 00:09:54,200
AND NOW AS I MENTIONED STAFF

257
00:09:54,200 --> 00:09:54,440
UPDATES.

258
00:09:54,440 --> 00:09:56,160
SORRY WE HAVEN'T BEEN ABLE TO

259
00:09:56,160 --> 00:09:57,600
HAVE THESE PEOPLE STAND UP AND

260
00:09:57,600 --> 00:09:59,320
SAY A FEW WORDS OVER THE LAST

261
00:09:59,320 --> 00:10:02,440
SESSIONS OF OUR COUNCIL MEETINGS

262
00:10:02,440 --> 00:10:03,080
BUT INSTEAD GIVEN THE

263
00:10:03,080 --> 00:10:06,080
CIRCUMSTANCES WE'RE GOING TO

264
00:10:06,080 --> 00:10:07,000
HAVE THE DIVISION DIRECTORS

265
00:10:07,000 --> 00:10:12,080
INTRODUCE THE NEW MEMBERS WHO 

266
00:10:12,080 --> 00:10:16,000
JOINED OUR STAFF. 

267
00:10:16,000 --> 00:10:17,720
>> RON, DO YOU WANT TO START?

268
00:10:17,720 --> 00:10:18,720
>>  I'M HERE.

269
00:10:18,720 --> 00:10:21,480
JUST A MATTER OF GETTING THE

270
00:10:21,480 --> 00:10:22,560
MOUSE TO COOPERATE.

271
00:10:22,560 --> 00:10:23,400
THANK YOU.

272
00:10:23,400 --> 00:10:27,520
I'D LIKE TO INTRODUCE HEALTH

273
00:10:27,520 --> 00:10:29,480
SCIENCE POLICY ANALYST SHOBHAN

274
00:10:29,480 --> 00:10:32,760
ADDIE, YOU CAN READ PARTICULARS.

275
00:10:32,760 --> 00:10:34,960
BACKGROUND, SHE WORKED WITH ONE

276
00:10:34,960 --> 00:10:41,080
OF OUR GRANTEES ON A Ph.D.

277
00:10:41,080 --> 00:10:42,720
THESIS ON DNA DAMAGE AND REPAIR,

278
00:10:42,720 --> 00:10:45,320
COMES TO US BY WAY OF NEW YORK

279
00:10:45,320 --> 00:10:47,960
ACADEMY OF SCIENCES AND NATIONAL

280
00:10:47,960 --> 00:10:50,480
ACADEMY OF SCIENCES ENGINEERING

281
00:10:50,480 --> 00:10:53,440
AND MEDICINE.

282
00:10:53,440 --> 00:10:55,080
DR. KATIYAR, HEALTH SCIENCE

283
00:10:55,080 --> 00:10:57,920
SPECIALIST IN SUPPORT OF THE

284
00:10:57,920 --> 00:11:00,520
CELLULAR SENESCENCE COMMON FUND

285
00:11:00,520 --> 00:11:00,760
NETWORK.

286
00:11:00,760 --> 00:11:04,760
AND SHE WAS AT THE NIA OFFICE OF

287
00:11:04,760 --> 00:11:06,000
PORTFOLIO ANALYSIS, Ph.D. IN

288
00:11:06,000 --> 00:11:08,600
TUMOR BIOLOGY WHICH THEN LED HER

289
00:11:08,600 --> 00:11:14,520
TO WORK AT NCI, EXPERIENCE IN

290
00:11:14,520 --> 00:11:29,400
PROGRAM FROM  NHLBI.

291
00:11:29,400 --> 00:11:31,000
LEONIT TSAP, IMAGING AND

292
00:11:31,000 --> 00:11:31,320
VISUALIZATION.

293
00:11:31,320 --> 00:11:35,280
HIS PROGRAM IS ON EMERGING

294
00:11:35,280 --> 00:11:36,480
TECHNOLOGIES AND DEVELOPING

295
00:11:36,480 --> 00:11:37,200
TECHNOLOGIES SPECIFICALLY FOR

296
00:11:37,200 --> 00:11:42,200
USE IN BIOLOGY OF AGING.

297
00:11:42,200 --> 00:11:45,120
DR. COG LIATI COMES FROM ITALY,

298
00:11:45,120 --> 00:11:49,120
VIA THE U.K., AND HAS

299
00:11:49,120 --> 00:11:51,280
CREDENTIALS IN WORK IN

300
00:11:51,280 --> 00:11:54,440
VISUALIZATION, AND VISION AND

301
00:11:54,440 --> 00:11:56,240
THE MECHANISMS OF VISUALIZATION,

302
00:11:56,240 --> 00:11:58,080
PARTICULARLY IN STEM CELLS AND

303
00:11:58,080 --> 00:11:59,560
IN THE DEGENERATION OF THE

304
00:11:59,560 --> 00:12:00,520
NERVOUS SYSTEM.

305
00:12:00,520 --> 00:12:04,000
SHE ALSO HAS VALUABLE EXPERIENCE

306
00:12:04,000 --> 00:12:05,600
IN COMPLEXITIES OF BIOBANKS.

307
00:12:05,600 --> 00:12:07,960
JENNIFER FOX COMES TO US FROM

308
00:12:07,960 --> 00:12:10,920
NCI DIVISION OF CANCER

309
00:12:10,920 --> 00:12:12,760
PREVENTION, SHE HAS SUBSTANTIAL

310
00:12:12,760 --> 00:12:15,120
EXPERTISE AS WELL IN DRUG

311
00:12:15,120 --> 00:12:16,800
DEVELOPMENT AND APPROVAL

312
00:12:16,800 --> 00:12:17,080
PROCESSES.

313
00:12:17,080 --> 00:12:19,440
WE ARE ECSTATIC TO HAVE THESE

314
00:12:19,440 --> 00:12:24,240
NEW MEMBERS OF OUR DIVISION.

315
00:12:24,240 --> 00:12:26,960
THANK YOU.

316
00:12:26,960 --> 00:12:27,880
>> NEXT UP, LIZ NEILSEN,

317
00:12:27,880 --> 00:12:29,680
DIVISION OF BEHAVIORAL AND

318
00:12:29,680 --> 00:12:30,720
SOCIAL RESEARCH.

319
00:12:30,720 --> 00:12:31,240
>> HI, EVERYONE.

320
00:12:31,240 --> 00:12:33,200
THANK YOU FOR THIS OPPORTUNITY

321
00:12:33,200 --> 00:12:38,240
TO INTRODUCE OUR NEW STAFF.

322
00:12:38,240 --> 00:12:40,200
WE RECENTLY WELCOMED DR. PETRA

323
00:12:40,200 --> 00:12:43,200
JACOBS TO LEAD OUR NEW OFFERS OF

324
00:12:43,200 --> 00:12:47,280
BEHAVIORAL AND SOCIAL CLINICAL

325
00:12:47,280 --> 00:12:49,160
TRIALS, DR. JACOBS COMES FROM

326
00:12:49,160 --> 00:12:51,880
NIDA, SHE HELD A POSITION AT

327
00:12:51,880 --> 00:12:53,640
CO-DIRECTOR OF NIDA CENTER FOR

328
00:12:53,640 --> 00:12:56,240
CLINICAL TRIALS NETWORK AND SHE

329
00:12:56,240 --> 00:12:58,920
HAS EXTENSIVE EXPERIENCE IN BOTH

330
00:12:58,920 --> 00:12:59,960
PHARMACOLOGICAL AND BEHAVIORAL

331
00:12:59,960 --> 00:13:02,560
TRIALS FOR DRUG ABUSE WHICH SHE

332
00:13:02,560 --> 00:13:04,080
NOW WILL BE APPLYING TO

333
00:13:04,080 --> 00:13:06,680
OVERSIGHT OF OUR PORTFOLIO OF

334
00:13:06,680 --> 00:13:09,480
OVER350 CLINICAL TRIALS THAT WE

335
00:13:09,480 --> 00:13:11,680
HAVE AND LEADING OUR CLINICAL

336
00:13:11,680 --> 00:13:13,480
TRIALS TEAM IN ADMINISTRATION

337
00:13:13,480 --> 00:13:15,480
THOSE GRANTS.

338
00:13:15,480 --> 00:13:21,520
WE'RE PLEASED TO WELCOME BACK

339
00:13:21,520 --> 00:13:25,240
DR. EMERALD NGUYEN, PROGRAM

340
00:13:25,240 --> 00:13:27,200
OFFICIAL, DEGREE IN SOCIALOLOGY,

341
00:13:27,200 --> 00:13:34,440
SHE WAS A AAAS FELLOW, HAD BEEN

342
00:13:34,440 --> 00:13:35,920
AT NIGMS IN ANALYTICS, SHE WILL

343
00:13:35,920 --> 00:13:39,800
BE TAKING OVER A PORTION OF OUR

344
00:13:39,800 --> 00:13:41,520
PORTFOLIO ON MACRO SOCIAL TRENDS

345
00:13:41,520 --> 00:13:45,840
IN AGING, LIFE COURSE HELD,

346
00:13:45,840 --> 00:13:46,120
AD/ADRD.

347
00:13:46,120 --> 00:13:46,880
NEXT SLIDE PLEASE.

348
00:13:46,880 --> 00:13:49,160
AS I MENTIONED IN OUR BREAKOUT

349
00:13:49,160 --> 00:13:52,360
GROUP, A LOT OF THE WORK WE DO

350
00:13:52,360 --> 00:13:54,440
IN BSR REALLY DEPENDS ON A

351
00:13:54,440 --> 00:13:56,200
TALENTED TEAM OF HEALTH

352
00:13:56,200 --> 00:13:58,760
SPECIALISTS AND SOCIAL SCIENCE

353
00:13:58,760 --> 00:14:00,000
ANALYSTS THAT ARE THE GLUE THAT

354
00:14:00,000 --> 00:14:03,280
ENABLE OUR WORK TO BE COMPLETED,

355
00:14:03,280 --> 00:14:03,880
CONDUCTING PORTFOLIO ANALYSES,

356
00:14:03,880 --> 00:14:05,280
SUPPORTING THE WORK THAT OUR

357
00:14:05,280 --> 00:14:06,480
MANY PROGRAM OFFICERS DO.

358
00:14:06,480 --> 00:14:09,160
AS THE DIVISION HAS GROWN, WE

359
00:14:09,160 --> 00:14:10,600
HAVE NOW BROUGHT ON BOARD NEW

360
00:14:10,600 --> 00:14:13,880
FOLKS TO HELP US WITH THIS

361
00:14:13,880 --> 00:14:15,720
REALLY LARGE WORKLOAD.

362
00:14:15,720 --> 00:14:17,920
WE'RE EXCITED TO WELCOME REBECCA

363
00:14:17,920 --> 00:14:19,760
RICKLIS IN THE INDIVIDUAL

364
00:14:19,760 --> 00:14:22,280
BEHAVIORAL PROCESSES BRANCH AS A

365
00:14:22,280 --> 00:14:25,040
HEALTH SPECIALIST, REBECCA WAS

366
00:14:25,040 --> 00:14:25,600
PREVIOUSLY AT JOHNS HOPKINS

367
00:14:25,600 --> 00:14:27,880
SCHOOL OF MEDICINE, AND HAS DONE

368
00:14:27,880 --> 00:14:32,040
SOME WORK IN HIV.

369
00:14:32,040 --> 00:14:34,200
CHARLES LE JOINED LAST WEEK IN

370
00:14:34,200 --> 00:14:35,920
THE POPULATION AND SOCIAL

371
00:14:35,920 --> 00:14:38,080
PROCESSES BRANCH, AND HE HAS AN

372
00:14:38,080 --> 00:14:40,120
NIH BACKGROUND AT THE CENTER OF

373
00:14:40,120 --> 00:14:41,320
SCIENTIFIC REVIEW WHICH WILL

374
00:14:41,320 --> 00:14:43,760
SERVE HIM WELL IN WORKING WITH

375
00:14:43,760 --> 00:14:45,880
US ON MANY ASPECTS OF INTERFACE

376
00:14:45,880 --> 00:14:48,240
BETWEEN PROGRAM AND REVIEW.

377
00:14:48,240 --> 00:14:50,440
NEXT SLIDE PLEASE.

378
00:14:50,440 --> 00:14:58,080
ADDING TO THE TEAM WE ALSO HAVE

379
00:14:58,080 --> 00:14:59,480
NICOLE KIDWILER, ASSISTING STAFF

380
00:14:59,480 --> 00:15:00,920
AND PROGRAM ANALYSTS SINCE

381
00:15:00,920 --> 00:15:02,000
JOINING FROM TOWSON UNIVERSITY,

382
00:15:02,000 --> 00:15:05,200
THE PATHWAYS PROGRAM IS A REALLY

383
00:15:05,200 --> 00:15:07,520
TERRIFIC WAY TO BRING YOUNG AND

384
00:15:07,520 --> 00:15:09,880
NEW FOLKS INTO THE FEDERAL

385
00:15:09,880 --> 00:15:10,840
WORKFORCE SO WE'RE PLEASED TO

386
00:15:10,840 --> 00:15:13,280
WELCOME NICOLE TO THE TEAM.

387
00:15:13,280 --> 00:15:18,480
AND OUR FINAL SOCIAL SCIENCE

388
00:15:18,480 --> 00:15:19,800
ANALYST ALLIE WALKER JOINING

389
00:15:19,800 --> 00:15:21,000
FROM OFFICE OF PLANNING RESEARCH

390
00:15:21,000 --> 00:15:22,600
AND EVALUATION AT THE

391
00:15:22,600 --> 00:15:23,960
ADMINISTRATION FOR CHILDREN AND

392
00:15:23,960 --> 00:15:26,560
FAMILIES, AND WILL BE ASSISTING

393
00:15:26,560 --> 00:15:28,320
WITH THE OTHER FOLKS IN

394
00:15:28,320 --> 00:15:30,480
SUPPORTING PROGRAM IN OUR

395
00:15:30,480 --> 00:15:32,040
MULTIPLE SCIENTIFIC ENDEAVORS.

396
00:15:32,040 --> 00:15:33,480
SO WELCOME ALL OF THEM AND THANK

397
00:15:33,480 --> 00:15:37,040
YOU FOR THE OPPORTUNITY TO

398
00:15:37,040 --> 00:15:40,680
INTRODUCE THEM. 

399
00:15:40,680 --> 00:15:47,560
>> NEXT UP IS DR. ELEAZAR

400
00:15:47,560 --> 00:15:47,920
MASNIOF.

401
00:15:47,920 --> 00:15:49,200
>> THANK YOU FOR THE

402
00:15:49,200 --> 00:15:49,720
OPPORTUNITY.

403
00:15:49,720 --> 00:15:52,160
IT'S MY PLEASURE TO INTRODUCE

404
00:15:52,160 --> 00:15:54,920
THREE NEW PROGRAM DIRECTORS TO

405
00:15:54,920 --> 00:15:58,720
THE DIVISION OF NEUROSCIENCE.

406
00:15:58,720 --> 00:16:01,560
FIRST PAUL GROTHAUS.

407
00:16:01,560 --> 00:16:06,400
HE WILL BE INTEGRAL PART NOW OF

408
00:16:06,400 --> 00:16:08,200
THE TRANSLATIONAL RESEARCH

409
00:16:08,200 --> 00:16:10,040
BRANCH, WORKING TOGETHER WITH

410
00:16:10,040 --> 00:16:13,120
LARRY ON A NUMBER OF NEW VERY

411
00:16:13,120 --> 00:16:15,480
EXCITING TRANSLATIONAL PROGRAMS

412
00:16:15,480 --> 00:16:16,800
THAT HAVE BEEN DEVELOPED, AND

413
00:16:16,800 --> 00:16:19,560
PAUL HAS A BACKGROUND IN

414
00:16:19,560 --> 00:16:20,720
MEDICINAL CHEMISTRY.

415
00:16:20,720 --> 00:16:24,840
HE  ACTUALLY ADVANCED A NUMBER

416
00:16:24,840 --> 00:16:27,240
OF DRUGS THROUGH THE PIPELINE

417
00:16:27,240 --> 00:16:28,680
AND HAS TREMENDOUS EXPERIENCE IN

418
00:16:28,680 --> 00:16:30,720
DRUG DEVELOPMENT AND JOINS US

419
00:16:30,720 --> 00:16:34,880
FROM -- HE WAS PREVIOUSLY AT

420
00:16:34,880 --> 00:16:35,360
NCI.

421
00:16:35,360 --> 00:16:39,360
NEXT ALSO ON THE TRANSLATION

422
00:16:39,360 --> 00:16:41,120
RESEARCH BRANCH JENNIFER ISAACS,

423
00:16:41,120 --> 00:16:43,960
SHE ALSO HAS A TREMENDOUS

424
00:16:43,960 --> 00:16:46,600
EXPERIENCE IN MOLECULAR BIOLOGY

425
00:16:46,600 --> 00:16:50,720
AND MOLECULAR MECHANISM, 

426
00:16:50,720 --> 00:16:51,960
CELLULAR MOLECULAR MECHANISMS

427
00:16:51,960 --> 00:16:53,920
INCLUDING CHAPERONES, WILL BE

428
00:16:53,920 --> 00:16:55,320
ALSO SUPPORTING THE

429
00:16:55,320 --> 00:16:56,960
TRANSLATIONAL RESEARCH BRANCH IN

430
00:16:56,960 --> 00:16:59,680
RELATION TO OUR RECENT EFFORTS

431
00:16:59,680 --> 00:17:01,880
IN PRECISION MEDICINE, AND SHE

432
00:17:01,880 --> 00:17:10,720
COMES TO US VIA BARDA AS WELL AS

433
00:17:10,720 --> 00:17:13,560
NCI.

434
00:17:13,560 --> 00:17:14,200
AND FINALLY ALESSANDRA

435
00:17:14,200 --> 00:17:18,680
ROVESCALLI FAMILIAR TO SOME OF

436
00:17:18,680 --> 00:17:19,880
YOU, A NEUROPHARMACOLOGIST, AND

437
00:17:19,880 --> 00:17:22,720
PREVIOUSLY AT THE CENTER FOR

438
00:17:22,720 --> 00:17:26,040
SCIENTIFIC REVIEW, AND SHE IS

439
00:17:26,040 --> 00:17:28,240
JOINING THE CLINICAL

440
00:17:28,240 --> 00:17:29,080
INTERVENTIONS AND DIAGNOSTICS

441
00:17:29,080 --> 00:17:34,240
BRANCH, WHERE SHE IS GOING TO BE

442
00:17:34,240 --> 00:17:37,080
WORKING TOGETHER WITH LORI AND

443
00:17:37,080 --> 00:17:39,480
OTHERS SUPPORTING THE

444
00:17:39,480 --> 00:17:42,160
DIAGNOSTICS PORTFOLIO AND

445
00:17:42,160 --> 00:17:44,040
BIOMARKERS PORTFOLIO AMONG OTHER

446
00:17:44,040 --> 00:17:46,320
FUNCTIONS, REALLY VERY EXCITED

447
00:17:46,320 --> 00:17:49,920
TO HAVE THESE NEW MEMBERS.

448
00:17:49,920 --> 00:17:52,120
AND THANK YOU.

449
00:17:52,120 --> 00:17:53,680
>> THANKS, ELEAZAR.

450
00:17:53,680 --> 00:17:58,040
NEXT UP IS DR. EVAN HADLEY,

451
00:17:58,040 --> 00:18:00,240
DIVISION OF GERIATRICS AND

452
00:18:00,240 --> 00:18:02,080
CLINICAL GERONTOLOGY.

453
00:18:02,080 --> 00:18:03,640
>> WE'RE PLEASED THAT KATHLEEN

454
00:18:03,640 --> 00:18:06,280
MERCURE JOINED US AS PROJECT

455
00:18:06,280 --> 00:18:09,280
MANAGER, COMES FROM NCI, AND HER

456
00:18:09,280 --> 00:18:14,080
MAIN ACTIVITIES HAVE BEEN IN

457
00:18:14,080 --> 00:18:17,120
COORDINATING AMONG OUR LARGE

458
00:18:17,120 --> 00:18:17,880
PROJECTS ON EXCEPTIONAL

459
00:18:17,880 --> 00:18:20,920
LONGEVITY THAT THESE HAVE BEEN

460
00:18:20,920 --> 00:18:23,880
RUNNING FOR QUITE A WHILE WITH

461
00:18:23,880 --> 00:18:27,400
POTENTIAL FOR SYNERGY WITH

462
00:18:27,400 --> 00:18:28,720
COHORT STUDIES, COLLABORATION,

463
00:18:28,720 --> 00:18:30,600
FAMILY STUDIES COLLABORATION,

464
00:18:30,600 --> 00:18:34,160
NEW STUDIES ON OMICS.

465
00:18:34,160 --> 00:18:36,680
AND GETTING THE COMMUNICATION

466
00:18:36,680 --> 00:18:37,560
AND ONGOING INTERACTIONS HAS

467
00:18:37,560 --> 00:18:39,760
BEEN A REAL CHALLENGE FOR THESE

468
00:18:39,760 --> 00:18:40,680
BIG PROJECTS, AND KATHLEEN

469
00:18:40,680 --> 00:18:46,120
REALLY HAS A FLAIR FOR IT AND

470
00:18:46,120 --> 00:18:47,760
WE'RE GRATEFUL SHE'S JOINED US.

471
00:18:47,760 --> 00:18:49,480
>> THANK YOU, EVAN.

472
00:18:49,480 --> 00:18:52,560
NEXT UP AGAIN, I'M KEN SANTORA,

473
00:18:52,560 --> 00:18:53,680
DIRECTOR OF DIVISION OF

474
00:18:53,680 --> 00:18:56,360
EXTRAMURAL ACTIVITIES, IT'S MY

475
00:18:56,360 --> 00:18:58,080
PLEASURE TO ANNOUNCE SIX NEW

476
00:18:58,080 --> 00:19:03,320
MEMBERS TO OUR DIVISION. 

477
00:19:03,320 --> 00:19:10,160
FIRST IS ASHLEY BUTTERFIELD

478
00:19:10,160 --> 00:19:11,440
HEALTH SPECIALIST FROM URBAN

479
00:19:11,440 --> 00:19:12,960
HOUSING AND DEVELOPMENT, NIH

480
00:19:12,960 --> 00:19:14,960
GUIDE LIAISON, WHICH IS THE

481
00:19:14,960 --> 00:19:17,120
PUBLICATION SYSTEM FOR ALL OUR

482
00:19:17,120 --> 00:19:17,680
FUNDING OPPORTUNITY

483
00:19:17,680 --> 00:19:18,440
ANNOUNCEMENTS HERE, SO SHE WILL

484
00:19:18,440 --> 00:19:21,840
BE IN CHARGE OF THAT.

485
00:19:21,840 --> 00:19:30,280
NEXT UP IS NEW SCIENTIFIC REVIEW

486
00:19:30,280 --> 00:19:31,320
OFFICER REY DOMINGUEZ FROM

487
00:19:31,320 --> 00:19:33,480
AUSTRALIA, HE'S GOING TO BE

488
00:19:33,480 --> 00:19:36,040
ORGANIZING THE INITIAL PEER

489
00:19:36,040 --> 00:19:38,160
REVIEW OF SPECIFIC RESEARCH

490
00:19:38,160 --> 00:19:41,920
APPLICATIONS THAT ARE ASSIGNED

491
00:19:41,920 --> 00:19:42,240
TO NIA.

492
00:19:42,240 --> 00:19:45,280
WE WELCOME REY.

493
00:19:45,280 --> 00:19:49,440
NEXT IS ANOTHER SCIENTIFIC

494
00:19:49,440 --> 00:19:51,160
REVIEW OFFICER, JOSHUA PARK,

495
00:19:51,160 --> 00:19:52,600
PREVIOUSLY WAS ASSISTANT

496
00:19:52,600 --> 00:19:56,000
PROFESSOR AT UNIVERSITY OF

497
00:19:56,000 --> 00:19:57,840
TOLEDO, COLLEGE OF MEDICINE, HE

498
00:19:57,840 --> 00:20:00,200
WILL BE OVERSEEING REVIEW OF THE

499
00:20:00,200 --> 00:20:01,880
CLINICAL SCIENCE SECTION, ONE OF

500
00:20:01,880 --> 00:20:03,400
OUR STANDING STUDY SECTIONS HERE

501
00:20:03,400 --> 00:20:07,680
AT NIA.

502
00:20:07,680 --> 00:20:10,640
NEXT SLIDE.

503
00:20:10,640 --> 00:20:13,480
NEXT IS LENIN GREENWOOD, NEW

504
00:20:13,480 --> 00:20:14,880
SUPERVISORY GRANTS MANAGEMENT

505
00:20:14,880 --> 00:20:15,200
SPECIALIST.

506
00:20:15,200 --> 00:20:17,960
SHE WAS PREVIOUSLY A SENIOR

507
00:20:17,960 --> 00:20:19,080
GRANTS MANAGEMENT SPECIALIST AT

508
00:20:19,080 --> 00:20:22,120
ONE OF OUR SISTER AGENCIES,

509
00:20:22,120 --> 00:20:22,480
NIDA.

510
00:20:22,480 --> 00:20:27,840
AND SHE'S GOING TO BE OVERSEEING

511
00:20:27,840 --> 00:20:30,440
THE BUSINESS MANAGEMENT AND

512
00:20:30,440 --> 00:20:31,520
OTHER NON-PROGRAMMATIC ASPECTS

513
00:20:31,520 --> 00:20:35,360
OF NOTICE OF AWARDS FOR NIA'S

514
00:20:35,360 --> 00:20:37,240
DIVISION OF GERIATRICS AND

515
00:20:37,240 --> 00:20:39,280
CLINICAL GERONTOLOGY.

516
00:20:39,280 --> 00:20:43,360
NEXT IS KENJA LEWIS, SHE IS AN

517
00:20:43,360 --> 00:20:45,440
EXTRAMURAL SUPPORT ASSISTANT.

518
00:20:45,440 --> 00:20:46,520
SHE JOINS US FROM PRIVATE

519
00:20:46,520 --> 00:20:50,640
INDUSTRY AND SHE'S GOING TO BE

520
00:20:50,640 --> 00:20:53,200
WORKING IN OUR OFFICE OF

521
00:20:53,200 --> 00:20:54,640
SCIENTIFIC REVIEW.

522
00:20:54,640 --> 00:20:56,920
AND SHE ASSISTS REVIEW OFFICERS

523
00:20:56,920 --> 00:20:58,760
IN ORGANIZING REVIEW MEETINGS,

524
00:20:58,760 --> 00:21:01,400
MAKING ARRANGEMENTS AND

525
00:21:01,400 --> 00:21:05,240
PREPARING SUMMARY STATEMENTS.

526
00:21:05,240 --> 00:21:07,600
AND FINALLY MISS REBECCA ROPER,

527
00:21:07,600 --> 00:21:09,880
SHE'S A HEALTH SCIENCE POLICY

528
00:21:09,880 --> 00:21:10,120
ANALYST.

529
00:21:10,120 --> 00:21:13,280
SHE IS NOW A NEW MEMBER OF OUR

530
00:21:13,280 --> 00:21:15,040
NEWLY CREATED OFFICE OF CLINICAL

531
00:21:15,040 --> 00:21:17,520
RESEARCH HERE IN THE DEA.

532
00:21:17,520 --> 00:21:21,600
SHE WAS PREVIOUSLY A PROGRAM

533
00:21:21,600 --> 00:21:24,080
OFFICER AT NHLBI, OVERSEEING THE

534
00:21:24,080 --> 00:21:27,480
OUTREACH TO COMMUNITY-BASED

535
00:21:27,480 --> 00:21:30,480
RESEARCH NETWORKS, ASSISTING

536
00:21:30,480 --> 00:21:33,720
WITH CROMS AND OUTREACHPRO, TWO

537
00:21:33,720 --> 00:21:36,600
MAJOR SYSTEMS CREATED FOR OUR

538
00:21:36,600 --> 00:21:40,680
CLINICAL RESEARCH OFFICE. 

539
00:21:40,680 --> 00:21:41,880
NEXT SLIDE.

540
00:21:41,880 --> 00:21:43,200
NEXT UP CONSIST DR. DAWN BERNARD

541
00:21:43,200 --> 00:21:45,800
TO INTRODUCE THE NEXT SPEAKERS

542
00:21:45,800 --> 00:21:48,280
BUT I WOULD FIRST LIKE TO

543
00:21:48,280 --> 00:21:51,080
ANNOUNCE DR. BERNARD HAS BEEN

544
00:21:51,080 --> 00:21:52,640
SELECTED TO SERVE AS NEW

545
00:21:52,640 --> 00:21:55,640
DIRECTOR OF THE OFFICE OF

546
00:21:55,640 --> 00:21:57,400
LEGISLATION POLICY AND

547
00:21:57,400 --> 00:21:58,680
INTERNATIONAL ACTIVITIES.

548
00:21:58,680 --> 00:22:01,880
SO CONGRATULATIONS TO DAWN FOR

549
00:22:01,880 --> 00:22:03,280
THAT PROMOTION.

550
00:22:03,280 --> 00:22:03,480
DAWN?

551
00:22:03,480 --> 00:22:03,840
>>  HI, KEN.

552
00:22:03,840 --> 00:22:05,240
CAN YOU HEAR ME OKAY?

553
00:22:05,240 --> 00:22:07,200
>>  YES, THANKS.

554
00:22:07,200 --> 00:22:07,640
>> THANK YOU.

555
00:22:07,640 --> 00:22:08,640
GOOD MORNING, EVERYONE.

556
00:22:08,640 --> 00:22:11,800
IT'S NICE TO MEET YOU VIRTUALLY.

557
00:22:11,800 --> 00:22:16,160
I WANTED TO INTRODUCE TWO NEW

558
00:22:16,160 --> 00:22:19,000
MEMBERS OF THE OLPIA TEAM.

559
00:22:19,000 --> 00:22:21,280
DR. LINDA YANG HEALTH SCIENCE

560
00:22:21,280 --> 00:22:26,240
POLICY ANALYST IN OUR OFFICE,

561
00:22:26,240 --> 00:22:29,400
COMES FROM NIAID'S OFFICE OF

562
00:22:29,400 --> 00:22:31,120
PLANNING AND EVALUATION, PhD

563
00:22:31,120 --> 00:22:34,000
in biomedical sciences from 

564
00:22:34,000 --> 00:22:35,440
Mount Sinai, helping NIA cover

565
00:22:35,440 --> 00:22:37,160
division of aging biology

566
00:22:37,160 --> 00:22:38,080
programs and supporting

567
00:22:38,080 --> 00:22:42,160
responses to Congress and other

568
00:22:42,160 --> 00:22:42,480
stakeholders.

569
00:22:42,480 --> 00:22:48,000
NEXT NEW ADDITION, WELL NEW TO 

570
00:22:48,000 --> 00:22:52,680
US AGAIN, COURTNEY WALLIN, DR.

571
00:22:52,680 --> 00:22:56,240
WALLIN FROM "ALL OF US," PRIOR

572
00:22:56,240 --> 00:22:58,200
TO THAT OFFICE OF LEGISLATION

573
00:22:58,200 --> 00:22:59,080
AND POLICY.

574
00:22:59,080 --> 00:23:02,400
SHE HAS HER Ph.D. IN COGNITIVE

575
00:23:02,400 --> 00:23:03,280
NEUROSCIENCE FROM GEORGE

576
00:23:03,280 --> 00:23:05,160
WASHINGTON UNIVERSITY, AND WILL

577
00:23:05,160 --> 00:23:07,240
BE COVERING FOR THE OFFICE

578
00:23:07,240 --> 00:23:08,880
DIVISION OF NEUROSCIENCE

579
00:23:08,880 --> 00:23:12,680
CLINICAL PORTFOLIO AS WELL AS

580
00:23:12,680 --> 00:23:13,800
OUR SBIR PORTFOLIO AND

581
00:23:13,800 --> 00:23:14,880
CHALLENGES ACTIVITIES.

582
00:23:14,880 --> 00:23:16,040
THANKS, KEN.

583
00:23:16,040 --> 00:23:17,720
>> THANKS, DAWN.

584
00:23:17,720 --> 00:23:18,840
NEXT SLIDE.

585
00:23:18,840 --> 00:23:21,320
NOW WE ASK CINDY MCCONNELL,

586
00:23:21,320 --> 00:23:24,080
DIRECTOR OF OFFICE OF

587
00:23:24,080 --> 00:23:27,480
COMMUNICATIONS AND PUBLIC

588
00:23:27,480 --> 00:23:28,320
LIAISON.

589
00:23:28,320 --> 00:23:28,520
CINDY?

590
00:23:28,520 --> 00:23:29,440
>>  GOOD MORNING.

591
00:23:29,440 --> 00:23:31,680
I'D LIKE TO WELCOME -- HOPEFULLY

592
00:23:31,680 --> 00:23:34,480
MY VIDEO IS WORKING.

593
00:23:34,480 --> 00:23:39,400
KATIE MURRAY AND ASHLEY NEGRO,

594
00:23:39,400 --> 00:23:42,080
BOTH KATIE AND ASHLEY CAME TO US

595
00:23:42,080 --> 00:23:45,960
FROM THE CENTERS FOR MEDICARE

596
00:23:45,960 --> 00:23:48,240
AND MEDICAID SERVICES, CMS, AND

597
00:23:48,240 --> 00:23:51,200
KATIE WILL BE FOCUSED ON WRITING

598
00:23:51,200 --> 00:23:53,840
CONSUMER HEALTH CONTENT, SHE'S A

599
00:23:53,840 --> 00:23:55,040
WRITER/EDITOR, AND ASHLEY IS

600
00:23:55,040 --> 00:23:56,800
FOCUSED ON OUR MEDIA RELATIONS

601
00:23:56,800 --> 00:24:02,880
BOTH PRO-ACTIVE AND  REACTIVE.

602
00:24:02,880 --> 00:24:05,480
A WARM WELCOME TO THEM BOTH.

603
00:24:05,480 --> 00:24:08,240
>> THANKS, CINDY.

604
00:24:08,240 --> 00:24:10,560
NEXT UP, HEAD OF OFFICE OF

605
00:24:10,560 --> 00:24:12,880
ADMINISTRATIVE MANAGEMENT.

606
00:24:12,880 --> 00:24:13,240
PATRICK?

607
00:24:13,240 --> 00:24:13,640
>>  THANKS, KEN.

608
00:24:13,640 --> 00:24:15,120
AM I COMING THROUGH OKAY?

609
00:24:15,120 --> 00:24:16,120
>> YES.

610
00:24:16,120 --> 00:24:16,760
>> GREAT.

611
00:24:16,760 --> 00:24:19,120
THANK YOU, EVERYBODY.

612
00:24:19,120 --> 00:24:19,880
GOOD MORNING.

613
00:24:19,880 --> 00:24:23,200
WE HAVE TWO NEW ADDITIONS,

614
00:24:23,200 --> 00:24:25,080
NICHOLAS CAPELL, JOINING OUR

615
00:24:25,080 --> 00:24:26,880
FINANCIAL MANAGEMENT BRANCH

616
00:24:26,880 --> 00:24:29,760
FOCUSING ON OUR GRANTS TEAM.

617
00:24:29,760 --> 00:24:31,280
COMES FROM UNIVERSITY OF OREGON,

618
00:24:31,280 --> 00:24:52,720
WE'RE EXCITED TO HAVE HIM. 

619
00:24:52,720 --> 00:24:57,280
DAYANA ALBA. 

620
00:24:57,280 --> 00:24:59,920
>> AND DR. LUIGI FERUGGI.

621
00:24:59,920 --> 00:25:01,320
>> GOOD MORNING, EVERYBODY.

622
00:25:01,320 --> 00:25:04,080
I'M GOING TO TALK TO YOU ABOUT

623
00:25:04,080 --> 00:25:06,800
THE FOUR PEOPLE THAT ARE FOUR

624
00:25:06,800 --> 00:25:14,120
NEW ENTRIES IN THE INTRAMURAL 

625
00:25:14,120 --> 00:25:17,840
PROGRAM, BUT I'LL GIVE YOU IN MY

626
00:25:17,840 --> 00:25:19,360
PRESENTATION A MUCH MORE

627
00:25:19,360 --> 00:25:20,880
COMPREHENSIVE VIEW OF THE

628
00:25:20,880 --> 00:25:23,760
INTRAMURAL PROGRAM.

629
00:25:23,760 --> 00:25:25,400
LINUS JOSEPH IS COMPUTER

630
00:25:25,400 --> 00:25:25,800
SCIENTIST.

631
00:25:25,800 --> 00:25:27,960
AS YOU KNOW, MOST OF THE SCIENCE

632
00:25:27,960 --> 00:25:30,240
WE DO PRODUCED MUCH MORE DATA

633
00:25:30,240 --> 00:25:34,480
THAN WE CAN CRUNCH, AND SO THAT

634
00:25:34,480 --> 00:25:37,480
REINFORCING, YOU KNOW, OUR I.T.

635
00:25:37,480 --> 00:25:39,080
DEPARTMENT HAS BEEN FUNDAMENTAL

636
00:25:39,080 --> 00:25:41,040
PROGRESS IN THE INTRAMURAL

637
00:25:41,040 --> 00:25:43,160
PROGRAM, AND LINUS IN PARTICULAR

638
00:25:43,160 --> 00:25:48,920
IS AN EXPERT IN PROGRAMMING IN 

639
00:25:48,920 --> 00:25:50,120
LINUX, AND OTHER LANGUAGES, AND

640
00:25:50,120 --> 00:25:53,080
HIS ROLE IS REALLY TO MODERNIZE

641
00:25:53,080 --> 00:25:56,480
SOME OF THE PROCESS AND

642
00:25:56,480 --> 00:25:57,800
PROCEDURES FUNDAMENTAL, MOSTLY

643
00:25:57,800 --> 00:25:59,640
TO MOVE DATA, WITHIN THE

644
00:25:59,640 --> 00:26:03,560
DIFFERENT PARTS OF THE

645
00:26:03,560 --> 00:26:05,880
INTRAMURAL PROGRAM.

646
00:26:05,880 --> 00:26:08,320
ANNAMARIA RUDDDEROW, OFFICE OF

647
00:26:08,320 --> 00:26:09,880
SCIENTIFIC DIRECTOR.

648
00:26:09,880 --> 00:26:12,840
YOU KNOW, THE WORK IN THE

649
00:26:12,840 --> 00:26:16,080
SCIENTIFIC DIRECTOR OFFICE HAS

650
00:26:16,080 --> 00:26:19,160
EXPANDED TREMENDOUSLY, IN PART

651
00:26:19,160 --> 00:26:22,040
BECAUSE OF THE ALZHEIMER'S

652
00:26:22,040 --> 00:26:23,960
DISEASE AND RELATED DEMENTIA

653
00:26:23,960 --> 00:26:26,400
OPERATION, ALSO BECAUSE WE HAVE

654
00:26:26,400 --> 00:26:27,960
LAUNCHED MANY INTERNAL

655
00:26:27,960 --> 00:26:29,760
COMPETITIVE INITIATIVES FOR

656
00:26:29,760 --> 00:26:31,360
FUNDING.

657
00:26:31,360 --> 00:26:33,120
AND SO THOSE ARE, YOU KNOW,

658
00:26:33,120 --> 00:26:37,080
REQUIRE A LOT OF, YOU KNOW,

659
00:26:37,080 --> 00:26:37,640
PROCESSES.

660
00:26:37,640 --> 00:26:42,040
FOR EXAMPLE, YOU KNOW, THIS YEAR

661
00:26:42,040 --> 00:26:44,880
WE HAD 69 PROJECT PROPOSALS THAT

662
00:26:44,880 --> 00:26:51,440
NEEDED TO BE REVIEWED, AND SO WE

663
00:26:51,440 --> 00:26:52,000
HIRED ANNAMARIA RUDDEROW,

664
00:26:52,000 --> 00:26:54,200
TURNING OUT TO BE A FANTASTIC

665
00:26:54,200 --> 00:27:07,600
ADDITION TO OFFICE OF SCIENTIFIC

666
00:27:07,600 --> 00:27:17,280
DIRECTOR. 

667
00:27:17,280 --> 00:27:21,360
VICTORIA DAVIS, PEOPLE COME OP

668
00:27:21,360 --> 00:27:21,920
SUNDAYS, EVENINGS, AVAILABLE

669
00:27:21,920 --> 00:27:23,440
EARLY IN THE MORNING FOR

670
00:27:23,440 --> 00:27:24,640
TESTING, VICTORIA HAS BEEN

671
00:27:24,640 --> 00:27:26,080
ALWAYS A FANTASTIC CONTRIBUTOR

672
00:27:26,080 --> 00:27:29,600
TO OUR PROGRAM SO SHE WAS HIRED

673
00:27:29,600 --> 00:27:35,520
AS A NIGHT NURSE. 

674
00:27:35,520 --> 00:27:37,120
FINALLY DAN BENJAMINI, A RECENT

675
00:27:37,120 --> 00:27:39,080
ACQUISITION IN THE TENURE TRACK

676
00:27:39,080 --> 00:27:39,320
PROGRAM.

677
00:27:39,320 --> 00:27:43,680
DAN CAME TO US FROM THE

678
00:27:43,680 --> 00:27:46,320
FOUNDATION FOR ADVANCEMENT OF

679
00:27:46,320 --> 00:27:48,080
MILITARY MEDICINE, TRULY UNIQUE

680
00:27:48,080 --> 00:27:48,680
SKILLS.

681
00:27:48,680 --> 00:27:51,280
HE IS AN IMAGING PERSON, MOSTLY

682
00:27:51,280 --> 00:27:54,240
WORKING ON MRI, BUT NOT ONLY

683
00:27:54,240 --> 00:27:58,400
MRI, AND HIS GOAL IS TO PUT

684
00:27:58,400 --> 00:28:05,280
TOGETHER, YOU KNOW, THE

685
00:28:05,280 --> 00:28:11,600
RELATIONSHIP BETWEEN IMAGING AND

686
00:28:11,600 --> 00:28:14,240
-- (INDISCERNIBLE), HIGH FIELD

687
00:28:14,240 --> 00:28:17,680
MRI IN MICE AND HUMANS, IN

688
00:28:17,680 --> 00:28:19,360
DEMENTIA STUDY OF THE SAME

689
00:28:19,360 --> 00:28:21,680
SECTION WITH MRI TO SEE WHETHER

690
00:28:21,680 --> 00:28:24,400
THERE ARE WAYS TO RECOGNIZE

691
00:28:24,400 --> 00:28:25,080
CHARACTERISTICS OF THESE

692
00:28:25,080 --> 00:28:25,840
TISSUES, FOR EXAMPLE ANOTHER

693
00:28:25,840 --> 00:28:33,600
THING HE WANTS TO DO IS

694
00:28:33,600 --> 00:28:34,440
RECOGNIZE (INDISCERNIBLE) AND

695
00:28:34,440 --> 00:28:36,000
HAS DEVELOPED A PROGRAM ABLE TO

696
00:28:36,000 --> 00:28:39,480
DO THAT, AT LEAST IN MICE SO

697
00:28:39,480 --> 00:28:41,480
FAR, AND IS JOINING OUR PROGRAM

698
00:28:41,480 --> 00:28:44,080
WHERE THERE IS CONSIDERABLE

699
00:28:44,080 --> 00:28:48,400
EXPERTISE IN IMAGING, AND SHE 

700
00:28:48,400 --> 00:28:50,040
WILL BE WORKING WITH SUSAN AND

701
00:28:50,040 --> 00:28:57,600
ALL THE OTHER INVESTIGATORS AT 

702
00:28:57,600 --> 00:28:57,760
NIA.

703
00:28:57,760 --> 00:28:58,360
>> THANK YOU, LUIGI.

704
00:28:58,360 --> 00:28:59,960
I'LL TURN IT BACK OVER TO DR.

705
00:28:59,960 --> 00:29:04,320
HOED ES.

706
00:29:04,320 --> 00:29:05,640
>> THANKS FOR THE INTRODUCTIONS

707
00:29:05,640 --> 00:29:07,280
SHARING THE EXCITEMENT OVER THE

708
00:29:07,280 --> 00:29:09,680
PAST MONTHS, EVEN YEARS IN

709
00:29:09,680 --> 00:29:09,880
COVID.

710
00:29:09,880 --> 00:29:11,760
NOT ONLY HAVE WE BEEN WORKING

711
00:29:11,760 --> 00:29:13,160
WITH YOU IN THE RESEARCH

712
00:29:13,160 --> 00:29:14,600
COMMUNITY AND PUBLIC TO KEEP

713
00:29:14,600 --> 00:29:19,200
THINGS GOING BUT WE'VE OF WE NOW

714
00:29:19,200 --> 00:29:23,480
HAVE THE EXCITEMENT OF BEING

715
00:29:23,480 --> 00:29:24,240
JOINED BY TALENTED, COMMITTED,

716
00:29:24,240 --> 00:29:25,960
VIGOROUS FOLKS YOU'VE SEEN AT

717
00:29:25,960 --> 00:29:27,480
LEAST REMOTELY.

718
00:29:27,480 --> 00:29:28,760
WE LOOK FORWARD FOR THE CHANCE

719
00:29:28,760 --> 00:29:30,680
FOR THEM TO MEET YOU IN PERSON

720
00:29:30,680 --> 00:29:32,280
AND EXPERIENCE INTERACTIONS WITH

721
00:29:32,280 --> 00:29:32,760
THEM.

722
00:29:32,760 --> 00:29:33,840
HERE THE FINAL SLIDE TO HELP

723
00:29:33,840 --> 00:29:35,480
REMIND YOU SOME OF THE WAYS TO

724
00:29:35,480 --> 00:29:38,320
STAY CONNECTED WITH NEWS AS IT

725
00:29:38,320 --> 00:29:38,760
HAPPENS.

726
00:29:38,760 --> 00:29:40,600
WE HOPE YOU WILL LOOK INTO THESE

727
00:29:40,600 --> 00:29:43,280
SITES FOR THE BLOG IN

728
00:29:43,280 --> 00:29:43,920
PARTICULAR, SUBSCRIBING, COMING

729
00:29:43,920 --> 00:29:45,880
TO YOU PROACTIVELY, ONE WAY TO

730
00:29:45,880 --> 00:29:48,160
KEEP IN TOUCH WITH EVENTS AS

731
00:29:48,160 --> 00:29:48,640
THEY HAPPEN.

732
00:29:48,640 --> 00:29:51,080
KEN, BACK TO YOU.

733
00:29:51,080 --> 00:29:52,080
>> THANKS, RICHARD.

734
00:29:52,080 --> 00:29:56,240
ANY QUESTIONS NOW FOR DR. HODES

735
00:29:56,240 --> 00:29:58,200
REGARDING HIS DIRECTOR'S STATUS

736
00:29:58,200 --> 00:29:58,440
REPORT?

737
00:29:58,440 --> 00:30:01,360
>>  I'VE GOT A QUESTION, IF I

738
00:30:01,360 --> 00:30:02,120
MAY.

739
00:30:02,120 --> 00:30:02,480
>> CERTAINLY.

740
00:30:02,480 --> 00:30:05,480
>> SO, THAT WAS SUCH A GREAT

741
00:30:05,480 --> 00:30:05,800
REPORT.

742
00:30:05,800 --> 00:30:07,600
TWO QUESTIONS, RICHARD.

743
00:30:07,600 --> 00:30:09,600
THAT IS, YOU SAID AT ONE POINT

744
00:30:09,600 --> 00:30:12,480
IN YOUR PRESENTATION THAT YOU

745
00:30:12,480 --> 00:30:14,280
HAD A NUMBER OF BRIEFINGS WITH

746
00:30:14,280 --> 00:30:18,240
CONGRESS, A NUMBER OF BRIEFINGS

747
00:30:18,240 --> 00:30:18,680
WITH CONSTITUENTS.

748
00:30:18,680 --> 00:30:21,000
HOW HAS THAT GONE UP OR DOWN

749
00:30:21,000 --> 00:30:25,880
DURING COVID, YOUR NUMBERS, ARE

750
00:30:25,880 --> 00:30:26,360
THEY THE SAME?

751
00:30:26,360 --> 00:30:29,400
>>  IT'S A GOOD QUESTION, TERRY.

752
00:30:29,400 --> 00:30:31,240
MY SENSE IS YES, PRETTY MUCH THE

753
00:30:31,240 --> 00:30:31,680
SAME.

754
00:30:31,680 --> 00:30:33,760
>> THAT'S GREAT.

755
00:30:33,760 --> 00:30:34,720
>> MEETINGS WITH CONSTITUENT AND

756
00:30:34,720 --> 00:30:36,480
ADVOCATE GROUPS, MANY OF THEM

757
00:30:36,480 --> 00:30:37,440
ARE REGULARLY SCHEDULED, AND

758
00:30:37,440 --> 00:30:38,880
THEY HAVE CONTINUED NOW, JUST

759
00:30:38,880 --> 00:30:41,160
REMOTE INSTEAD OF IN PERSON.

760
00:30:41,160 --> 00:30:42,680
SIMILARLY FOR BRIEFINGS AND

761
00:30:42,680 --> 00:30:43,040
HEARINGS.

762
00:30:43,040 --> 00:30:44,440
>> THAT'S GREAT.

763
00:30:44,440 --> 00:30:46,720
AND PART 2 QUICKLY IS YOU HAVE

764
00:30:46,720 --> 00:30:48,600
INTRODUCED US TO AN ARRAY OF

765
00:30:48,600 --> 00:30:49,480
WONDERFUL NEW STAFF.

766
00:30:49,480 --> 00:30:51,680
ARE YOU NET POSITIVE OR NET

767
00:30:51,680 --> 00:30:54,440
NEGATIVE IN YOUR STAFFING NOW?

768
00:30:54,440 --> 00:30:57,880
>>  VERY SIGNIFICANTLY POSITIVE.

769
00:30:57,880 --> 00:30:58,680
>> GREAT.

770
00:30:58,680 --> 00:31:01,080
>> SOME YEARS WE WERE AT STEADY

771
00:31:01,080 --> 00:31:03,040
STATE, EVEN AS OUR SCOPE AND

772
00:31:03,040 --> 00:31:04,040
BUDGET INCREASED.

773
00:31:04,040 --> 00:31:07,160
BUT WE HAVE HAD THE OKAY TO DO

774
00:31:07,160 --> 00:31:08,040
SUBSTANTIAL RECRUITMENT.

775
00:31:08,040 --> 00:31:09,440
SO WE'RE WORKING EACH YEAR

776
00:31:09,440 --> 00:31:12,520
ACROSS ALL THE PROGRAMS AND

777
00:31:12,520 --> 00:31:14,920
DIVISIONS FOR STRATEGIC PLANS,

778
00:31:14,920 --> 00:31:19,520
ASK WHAT'S NEEDED, SO FAR HAVE 

779
00:31:19,520 --> 00:31:22,040
BEEN ABLE TO MEET NEEDS AND

780
00:31:22,040 --> 00:31:22,400
EXPAND.

781
00:31:22,400 --> 00:31:24,000
INCREASING STAFFING TO MEET THE

782
00:31:24,000 --> 00:31:26,360
DIVERSITY AND EXTENT OF OUR

783
00:31:26,360 --> 00:31:27,960
SCIENCE INTERACTIONS WITH ALL OF

784
00:31:27,960 --> 00:31:28,120
YOU.

785
00:31:28,120 --> 00:31:31,120
>> ABSOLUTELY WONDERFUL.

786
00:31:31,120 --> 00:31:37,800
THANK YOU. 

787
00:31:37,800 --> 00:31:38,640
>> OTHER QUESTIONS?

788
00:31:38,640 --> 00:31:38,880
>>  SALLY?

789
00:31:38,880 --> 00:31:44,240
>>  YES, I WANT TO CONGRATULATE

790
00:31:44,240 --> 00:31:47,360
YOU, NIA AND STAFF FOR AMOUNT OF

791
00:31:47,360 --> 00:31:49,680
WORK AND QUITE A SPECTACULAR

792
00:31:49,680 --> 00:31:51,080
GROWTH IN NIA'S PORTFOLIO OVER

793
00:31:51,080 --> 00:31:57,280
THE LAST DECADE.

794
00:31:57,280 --> 00:31:58,680
THAT'S WONDERFUL AND

795
00:31:58,680 --> 00:31:59,000
ENCOURAGING.

796
00:31:59,000 --> 00:32:01,640
ONE FEEDBACK THAT I AND OTHERS

797
00:32:01,640 --> 00:32:04,880
ARE RECEIVING FROM JUNIOR 

798
00:32:04,880 --> 00:32:06,200
COLLEAGUES IS EXTRAORDINARY

799
00:32:06,200 --> 00:32:08,320
AMOUNT OF PAPERWORK AND

800
00:32:08,320 --> 00:32:11,240
REGULATORY BURDEN THAT NEW

801
00:32:11,240 --> 00:32:13,360
GUIDELINES AND IMPLEMENTATION OF

802
00:32:13,360 --> 00:32:15,600
THE PREVIOUS GUIDELINES ARE

803
00:32:15,600 --> 00:32:17,400
IMPOSING ON JUNIOR COLLEAGUES.

804
00:32:17,400 --> 00:32:20,480
SUCH A LARGE PORTION OF THE

805
00:32:20,480 --> 00:32:24,400
GRANT SUBMISSION RELATES TO

806
00:32:24,400 --> 00:32:27,800
ADMINISTRATIVE ASPECTS, THAT THE

807
00:32:27,800 --> 00:32:28,480
INVESTIGATORS, INDIVIDUAL

808
00:32:28,480 --> 00:32:29,840
INVESTIGATORS, ESPECIALLY JUNIOR

809
00:32:29,840 --> 00:32:30,680
INVESTIGATORS, HAVE VERY LITTLE

810
00:32:30,680 --> 00:32:31,880
CONTROL OVER.

811
00:32:31,880 --> 00:32:33,640
AND FIND IT EXCEEDINGLY

812
00:32:33,640 --> 00:32:37,040
DIFFICULT TO MANAGE, EVEN THINGS

813
00:32:37,040 --> 00:32:40,440
LIKE THOUSAND DOLLAR TRAVEL HAS

814
00:32:40,440 --> 00:32:42,800
TO BE EXPLAINED MULTIPLE TIMES,

815
00:32:42,800 --> 00:32:44,120
IN GREAT DETAIL.

816
00:32:44,120 --> 00:32:47,840
AND ALTHOUGH THIS IS NOT

817
00:32:47,840 --> 00:32:48,640
ENTIRELY NIA'S PURVIEW, I THINK

818
00:32:48,640 --> 00:32:51,680
WE GET THE SAME FEEDBACK FROM

819
00:32:51,680 --> 00:32:52,480
VARIOUS INSTITUTES, I THINK

820
00:32:52,480 --> 00:32:54,280
THERE NEEDS TO BE SOME ATTENTION

821
00:32:54,280 --> 00:32:57,480
GIVEN TO WHAT THE REVIEWERS CAN

822
00:32:57,480 --> 00:33:03,800
REVIEW MEANINGFULLY AND WHAT THE

823
00:33:03,800 --> 00:33:04,440
INVESTIGATORS CAN MEANINGFULLY

824
00:33:04,440 --> 00:33:06,240
AND PRACTICALLY MANAGE IN TERMS

825
00:33:06,240 --> 00:33:07,840
OF THE ADMINISTRATIVE ASSURANCES

826
00:33:07,840 --> 00:33:12,960
AND BURDEN THAT IT IMPOSES.

827
00:33:12,960 --> 00:33:14,680
>> THANK YOU FOR THE THOUGHTFUL

828
00:33:14,680 --> 00:33:14,960
COMMENTS.

829
00:33:14,960 --> 00:33:16,120
WE NEED TO PAY ATTENTION.

830
00:33:16,120 --> 00:33:19,400
KEN, DO YOU HAVE ANY SPECIFIC

831
00:33:19,400 --> 00:33:19,680
RESPONSE?

832
00:33:19,680 --> 00:33:21,880
INCLUDING THE CHANNELS BY WHICH

833
00:33:21,880 --> 00:33:23,320
WE CONVEY THESE KINDS OF

834
00:33:23,320 --> 00:33:24,240
CONCERNS.

835
00:33:24,240 --> 00:33:25,760
>> YES.

836
00:33:25,760 --> 00:33:27,480
WE CERTAINLY RECOGNIZE THOSE

837
00:33:27,480 --> 00:33:28,120
CONCERNS.

838
00:33:28,120 --> 00:33:31,000
AND ALWAYS TAKE THAT INTO

839
00:33:31,000 --> 00:33:33,000
CONSIDERATION WHEN WE'RE

840
00:33:33,000 --> 00:33:34,200
IMPLEMENTING NEW POLICIES,

841
00:33:34,200 --> 00:33:34,680
ESPECIALLY.

842
00:33:34,680 --> 00:33:38,480
I THINK THERE'S BEEN A CONCERTED

843
00:33:38,480 --> 00:33:39,320
EFFORT EVER SINCE THE 21ST

844
00:33:39,320 --> 00:33:41,320
CENTURY CURES ACT CAME OUT

845
00:33:41,320 --> 00:33:42,680
DURING THE OBAMA ADMINISTRATION.

846
00:33:42,680 --> 00:33:45,040
ONE OF THE TENETS OF THAT WAS TO

847
00:33:45,040 --> 00:33:47,520
TRY TO REDUCE ADMINISTRATIVE

848
00:33:47,520 --> 00:33:47,960
BURDEN.

849
00:33:47,960 --> 00:33:49,160
AND WE REALLY RECOGNIZE HOW MUCH

850
00:33:49,160 --> 00:33:53,320
A BURDEN THAT IS ESPECIALLY IN

851
00:33:53,320 --> 00:33:54,360
OUR EARLY CAREER AWARDEES

852
00:33:54,360 --> 00:33:56,960
BECAUSE OF, YOU KNOW, SETTING UP

853
00:33:56,960 --> 00:33:59,920
LABORATORIES, ET CETERA, YOU

854
00:33:59,920 --> 00:34:02,560
KNOW, WRITING GRANTS, MANAGING.

855
00:34:02,560 --> 00:34:04,480
VERY DIFFICULT TO MANAGE ALL

856
00:34:04,480 --> 00:34:06,200
THOSE COMPONENTS.

857
00:34:06,200 --> 00:34:07,920
WE DO RECOGNIZE THAT.

858
00:34:07,920 --> 00:34:11,760
YOU KNOW, WE'RE TRYING TO

859
00:34:11,760 --> 00:34:16,240
IMPLEMENT EFFICIENCIES WHERE WE

860
00:34:16,240 --> 00:34:18,320
CAN, ESPECIALLY THROUGH OUR

861
00:34:18,320 --> 00:34:20,840
ELECTRONIC AND I.T. DEPARTMENTS.

862
00:34:20,840 --> 00:34:23,320
YOU KNOW, TO MAKE THINGS MUCH

863
00:34:23,320 --> 00:34:28,960
MORE ARE STREAMLINED AND EASIER

864
00:34:28,960 --> 00:34:32,680
TO MAKE ALL THOSE REQUIREMENTS.

865
00:34:32,680 --> 00:34:34,080
WE'RE INTEGRALLY INVOLVED ALWAYS

866
00:34:34,080 --> 00:34:39,040
IN THOSE REQUIREMENTS.

867
00:34:39,040 --> 00:34:43,160
AND WE UNDERSTAND, BECAUSE AS

868
00:34:43,160 --> 00:34:43,960
ADMINISTRATORS OF THOSE GRANTS

869
00:34:43,960 --> 00:34:48,760
THOSE TIMES TEN ARE ON US ALSO.

870
00:34:48,760 --> 00:34:51,040
AND WE THOROUGHLY UNDERSTAND

871
00:34:51,040 --> 00:34:51,600
THAT.

872
00:34:51,600 --> 00:34:52,880
UNFORTUNATELY, THE NECESSITY OF

873
00:34:52,880 --> 00:34:55,320
DOING THOSE, BECAUSE MOST OF

874
00:34:55,320 --> 00:34:56,960
THEM ARE BY REGULATION AND LAW

875
00:34:56,960 --> 00:34:57,840
THROUGH THE FEDERAL GOVERNMENT,

876
00:34:57,840 --> 00:35:02,760
AND SO WE DON'T HAVE A LOT OF

877
00:35:02,760 --> 00:35:04,720
CHOICES IN IMPLEMENTING THOSE

878
00:35:04,720 --> 00:35:05,680
TYPES OF THINGS.

879
00:35:05,680 --> 00:35:09,600
BUT WE ARE ALWAYS TRYING TO HELP

880
00:35:09,600 --> 00:35:10,560
OUR INVESTIGATORS, AND, AGAIN,

881
00:35:10,560 --> 00:35:12,880
TRYING TO COME UP WITH SOME

882
00:35:12,880 --> 00:35:14,280
EFFICIENCIES AS MUCH AS

883
00:35:14,280 --> 00:35:14,680
POSSIBLE.

884
00:35:14,680 --> 00:35:17,040
SO, BUT AGAIN IT'S A VERY GOOD

885
00:35:17,040 --> 00:35:17,560
QUESTION.

886
00:35:17,560 --> 00:35:21,600
AND WE'RE CONSTANTLY LOOKING FOR

887
00:35:21,600 --> 00:35:23,640
NEW INNOVATIVE WAYS TO ALLEVIATE

888
00:35:23,640 --> 00:35:24,680
THOSE ADMINISTRATIVE BURDENS

889
00:35:24,680 --> 00:35:26,040
WHEN POSSIBLE.

890
00:35:26,040 --> 00:35:27,680
>> I ONLY ADD WE APPRECIATE YOU

891
00:35:27,680 --> 00:35:28,880
RAISING THE QUESTIONS, AND

892
00:35:28,880 --> 00:35:35,000
WELCOME YOUR HELP AND AYE SIS

893
00:35:35,000 --> 00:35:36,640
TANS, SHALI AND COUNCIL, IF

894
00:35:36,640 --> 00:35:37,400
THERE'S SPECIFIC QUESTIONS WE

895
00:35:37,400 --> 00:35:38,840
CAN LOOK INTO AND TEST

896
00:35:38,840 --> 00:35:41,080
NECESSITY, WHETHER THERE'S ROOM

897
00:35:41,080 --> 00:35:42,560
FOR MODIFICATION.

898
00:35:42,560 --> 00:35:44,720
SO PLEASE CONTINUE TO CONVEY THE

899
00:35:44,720 --> 00:35:47,720
GENERAL CONCERNS BUT ALSO ANY 

900
00:35:47,720 --> 00:35:49,320
SPECIFIC THOUGHTS YOU HAVE.

901
00:35:49,320 --> 00:35:50,640
>> I'LL SEND AN E-MAIL WITH SOME

902
00:35:50,640 --> 00:35:53,040
THOUGHTS ON IT BUT I'M GETTING

903
00:35:53,040 --> 00:36:04,440
SO MUCH FEEDBACK WITHIN OUR 

904
00:36:04,440 --> 00:36:05,640
PEPPERER CENTER, I CAN'T TELL

905
00:36:05,640 --> 00:36:08,080
WHAT THE AIRFARE IS TODAY VERSUS

906
00:36:08,080 --> 00:36:13,240
TOMORROW AND TO EXPECT A 

907
00:36:13,240 --> 00:36:15,880
RATIONALIZATION OF A THOUSAND

908
00:36:15,880 --> 00:36:17,720
DOLLARS IN TRAVEL EXPENSES SEEMS

909
00:36:17,720 --> 00:36:19,040
MUCH, AN EXTREME EXAMPLE,

910
00:36:19,040 --> 00:36:20,880
PERHAPS I HOPE AN UNCOMMON

911
00:36:20,880 --> 00:36:21,280
EXAMPLE.

912
00:36:21,280 --> 00:36:24,560
BUT 80% OF THE GRANT TODAY IS

913
00:36:24,560 --> 00:36:26,320
NOT RELATED TO THE SCIENCE PART

914
00:36:26,320 --> 00:36:27,320
OF IT.

915
00:36:27,320 --> 00:36:29,720
AND SO MANY OF THESE

916
00:36:29,720 --> 00:36:32,600
ADMINISTRATIVE ASSURANCES CAN BE

917
00:36:32,600 --> 00:36:34,880
ASSIGNED TO THE NIH-FUNDED

918
00:36:34,880 --> 00:36:35,240
INSTITUTIONS.

919
00:36:35,240 --> 00:36:39,360
AND IT SEEMS TO ME TO PUT THOSE

920
00:36:39,360 --> 00:36:41,560
150 PAGES INTO A GRANT DOESN'T

921
00:36:41,560 --> 00:36:43,520
DO MUCH BECAUSE I AS A REVIEWER

922
00:36:43,520 --> 00:36:47,040
HAVE VERY LITTLE TIME TO READ

923
00:36:47,040 --> 00:36:49,160
THOSE 150 PAGES.

924
00:36:49,160 --> 00:36:51,600
AT ANY RATE, I RECOGNIZE THAT

925
00:36:51,600 --> 00:36:55,560
IT'S NOT ENTIRELY WITHIN THE

926
00:36:55,560 --> 00:36:58,480
INSTITUTE NIA'S PURVIEW.

927
00:36:58,480 --> 00:37:03,520
BUT IF IT'S NOT 27 INSTITUTES

928
00:37:03,520 --> 00:37:05,400
PURVIEW WHOSE IS IT AND HOW CAN

929
00:37:05,400 --> 00:37:07,320
WE ACCESS AND PROVIDE FEEDBACK

930
00:37:07,320 --> 00:37:11,480
TO TOP LEADERSHIP SETTING THESE

931
00:37:11,480 --> 00:37:11,760
POLICIES?

932
00:37:11,760 --> 00:37:15,680
>>  AGAIN, THANK YOU FOR THAT,

933
00:37:15,680 --> 00:37:16,080
SHALI.

934
00:37:16,080 --> 00:37:18,920
PLEASE SEND ME AND DR. HODES

935
00:37:18,920 --> 00:37:21,880
SUGGESTIONS AND WE CAN FUNNEL TO

936
00:37:21,880 --> 00:37:23,320
LEADERSHIP AT NIH TO MAKE SURE

937
00:37:23,320 --> 00:37:24,880
THAT'S ALWAYS ON THE AGENDA.

938
00:37:24,880 --> 00:37:28,600
I CAN ALSO ASSURE YOU THESE 

939
00:37:28,600 --> 00:37:31,240
DISCUSSIONS LIKE THIS ARE ALWAYS

940
00:37:31,240 --> 00:37:35,480
HIGH IN PRIORITY TO THE NIH, AT

941
00:37:35,480 --> 00:37:37,040
THE HIGHEST LEVELS, BECAUSE

942
00:37:37,040 --> 00:37:38,680
OBVIOUSLY YOU'RE NOT THE ONLY

943
00:37:38,680 --> 00:37:41,640
ONES THAT ARE BRINGING THIS TO

944
00:37:41,640 --> 00:37:43,160
OUR ATTENTION THROUGHOUT THAT,

945
00:37:43,160 --> 00:37:45,440
AND WE'RE WORKING THROUGH

946
00:37:45,440 --> 00:37:45,960
CHANNELS.

947
00:37:45,960 --> 00:37:47,200
BUT THE MORE EVIDENCE AND MORE

948
00:37:47,200 --> 00:37:48,720
WE HEAR FROM YOU, THE BETTER.

949
00:37:48,720 --> 00:37:50,600
AND WE CAN KEEP THAT

950
00:37:50,600 --> 00:37:51,600
CONVERSATION GOING ALWAYS.

951
00:37:51,600 --> 00:37:53,800
AND TRY TO WORK THROUGH THINGS

952
00:37:53,800 --> 00:37:55,200
TO MAKE IT BETTER.

953
00:37:55,200 --> 00:38:00,000
>> THANK YOU, KEN.

954
00:38:00,000 --> 00:38:04,120
THANK YOU, RICHARD.

955
00:38:04,120 --> 00:38:05,240
>> ANY OTHER QUESTIONS?

956
00:38:05,240 --> 00:38:07,160
SO OF COURSE WE'LL STAY TUNED

957
00:38:07,160 --> 00:38:10,240
FOR, YOU KNOW, HOPEFULLY WE'LL

958
00:38:10,240 --> 00:38:14,040
GET A BUDGET IN THE NEXT THREE

959
00:38:14,040 --> 00:38:14,240
WEEKS.

960
00:38:14,240 --> 00:38:15,800
WE'LL SEE.

961
00:38:15,800 --> 00:38:16,840
BUT LOTS DEPEND ON THAT, YOU

962
00:38:16,840 --> 00:38:23,560
KNOW, TOO SO STAY TUNED FOR

963
00:38:23,560 --> 00:38:24,440
THAT.

964
00:38:24,440 --> 00:38:25,360
OKAY.

965
00:38:25,360 --> 00:38:28,200
>> MERRILL HAD A COMMENT.

966
00:38:28,200 --> 00:38:29,240
>> YES, DR. HODES, I THINK ONE

967
00:38:29,240 --> 00:38:32,280
OF THE SLIDES THAT YOU PUT FORTH

968
00:38:32,280 --> 00:38:35,360
REALLY SPEAKS TO THE

969
00:38:35,360 --> 00:38:37,040
PRODUCTIVITY ON THE ACTIVE

970
00:38:37,040 --> 00:38:38,160
CLINICAL TRIALS UNDERWAY.

971
00:38:38,160 --> 00:38:41,080
I THINK THAT SHOULD BE USED MORE

972
00:38:41,080 --> 00:38:44,680
OFTEN BECAUSE IT REALLY GIVES A

973
00:38:44,680 --> 00:38:46,840
SNAPSHOT OF HOW EFFECTIVE THE

974
00:38:46,840 --> 00:38:49,560
NIA HAS BEEN AND ACROSS VARIOUS

975
00:38:49,560 --> 00:38:50,280
DOMAINS.

976
00:38:50,280 --> 00:38:53,480
MY QUESTION TO YOU IS CAN YOU

977
00:38:53,480 --> 00:38:58,000
GIVE US ANYPLACE INSIGHT INTO

978
00:38:58,000 --> 00:39:01,480
ARPA-H AND HOW ITS POTENTIAL

979
00:39:01,480 --> 00:39:03,120
IMPACT ON THE NIA?

980
00:39:03,120 --> 00:39:07,200
>>  THANKS FOR THAT COMMENT AND

981
00:39:07,200 --> 00:39:08,560
QUESTION, MERYL.

982
00:39:08,560 --> 00:39:11,880
NOT MUCH CAN I SHARE BECAUSE NOT

983
00:39:11,880 --> 00:39:13,600
MUCH HAS BEEN DETERMINED.

984
00:39:13,600 --> 00:39:15,400
THE ARPA-H PROPOSAL IS NOT YET

985
00:39:15,400 --> 00:39:19,120
PASSED THROUGH AT THE LEVEL OF

986
00:39:19,120 --> 00:39:20,040
EITHER AUTHORIZATION OR

987
00:39:20,040 --> 00:39:20,360
APPROPRIATION.

988
00:39:20,360 --> 00:39:22,000
SO IN GENERAL OF COURSE THE

989
00:39:22,000 --> 00:39:23,960
VISUALIZATION HAS BEEN IT'S

990
00:39:23,960 --> 00:39:25,520
SOMETHING LIKE DARPA, WHICH

991
00:39:25,520 --> 00:39:29,440
MEANS IT HAS PARTICULAR

992
00:39:29,440 --> 00:39:33,920
MECHANISMS FOR FACILITATING 

993
00:39:33,920 --> 00:39:35,240
PARTNERSHIPS, RAPID PROGRESS,

994
00:39:35,240 --> 00:39:36,760
MILESTONE-DRIVEN DETERMINATIONS

995
00:39:36,760 --> 00:39:39,480
OF SUCCESS OR FAILURE AT A

996
00:39:39,480 --> 00:39:41,040
PROJECT LEVEL.

997
00:39:41,040 --> 00:39:43,320
THE DECISION ABOUT WHETHER THERE

998
00:39:43,320 --> 00:39:46,160
WILL BE AN ARPA-H, IF THERE IS

999
00:39:46,160 --> 00:39:47,880
ONE WHETHER IT WILL BE WITHIN

1000
00:39:47,880 --> 00:39:50,880
NIH OR NOT, IS STILL A MATTER OF

1001
00:39:50,880 --> 00:39:54,160
SOME CONGRESSIONAL DISCUSSION.

1002
00:39:54,160 --> 00:39:55,800
AGAIN, IT NEEDS AUTHORIZATION

1003
00:39:55,800 --> 00:39:57,880
AND APPROPRIATION OF FUNDS,

1004
00:39:57,880 --> 00:39:59,280
NEITHER OF WHICH HAS YET

1005
00:39:59,280 --> 00:39:59,560
OCCURRED.

1006
00:39:59,560 --> 00:40:01,400
IF THERE'S A COMMON THEME FOR

1007
00:40:01,400 --> 00:40:04,560
DISCUSSIONS IF THIS COMES TO BE,

1008
00:40:04,560 --> 00:40:07,200
WHETHER WITHIN NIH OR NOT, IT

1009
00:40:07,200 --> 00:40:11,560
HAS TO BE SOMETHING QUITE

1010
00:40:11,560 --> 00:40:12,880
DISTINCT AND INDEPENDENT AT

1011
00:40:12,880 --> 00:40:14,280
LEVEL OF MANAGEMENT FROM NIH.

1012
00:40:14,280 --> 00:40:16,680
NOT MORE OF THE SAME, NOT TO

1013
00:40:16,680 --> 00:40:19,040
UNDERMINE THE VALUE OF WHAT NIH

1014
00:40:19,040 --> 00:40:21,560
DOES BUT IF IT'S VALUE ADDED IT

1015
00:40:21,560 --> 00:40:23,680
HAS TO HAVE A LEVEL OF AUTONOMY

1016
00:40:23,680 --> 00:40:27,680
WHILE IT ENTER ACCOUNT  A --

1017
00:40:27,680 --> 00:40:30,400
INTERACTS WITH NIH, VERY LITTLE

1018
00:40:30,400 --> 00:40:33,680
IN RECENT WEEKS, CONGRESSIONAL

1019
00:40:33,680 --> 00:40:34,560
LEVEL, AUTHORIZATION OR

1020
00:40:34,560 --> 00:40:36,680
APPROPRIATION. 

1021
00:40:36,680 --> 00:40:37,480
WE'LL KEEP YOU INFORMED AS

1022
00:40:37,480 --> 00:40:38,840
YOU'RE INTERESTED IN THE OUTCOME

1023
00:40:38,840 --> 00:40:47,600
OF THIS. 

1024
00:40:47,600 --> 00:40:48,480
>> THANK YOU.

1025
00:40:48,480 --> 00:40:49,320
>> THERE'S VERY LIMITED LANGUAGE

1026
00:40:49,320 --> 00:40:52,520
WHEN IT CAME TO WHAT WAS BEING

1027
00:40:52,520 --> 00:40:53,280
PROPOSED DURING ARPA-H.

1028
00:40:53,280 --> 00:40:55,120
ONE OF THE THINGS THEY DID POINT

1029
00:40:55,120 --> 00:40:58,840
OUT IN THAT WAS ALZHEIMER'S

1030
00:40:58,840 --> 00:40:59,840
DISEASE.

1031
00:40:59,840 --> 00:41:02,080
SO WE ARE IN, YOU KNOW, KEEPING

1032
00:41:02,080 --> 00:41:04,080
THAT UNDER CONSIDERATION WHEN

1033
00:41:04,080 --> 00:41:07,480
WE'RE THINKING OF THE FUTURE 

1034
00:41:07,480 --> 00:41:09,440
AND FUTURE PROJECTS FOR THE

1035
00:41:09,440 --> 00:41:09,680
INSTITUTE.

1036
00:41:09,680 --> 00:41:12,360
>> YES, THE ORIGINAL LANGUAGE

1037
00:41:12,360 --> 00:41:13,120
FROM THE PRESIDENT, ALZHEIMER'S

1038
00:41:13,120 --> 00:41:14,880
WAS ONE OF THREE EXAMPLES OF

1039
00:41:14,880 --> 00:41:19,360
DISEASE ALONG WITH CANCER THAT

1040
00:41:19,360 --> 00:41:21,320
HE CITED. 

1041
00:41:21,320 --> 00:41:24,080
>> ALL RIGHT.

1042
00:41:24,080 --> 00:41:30,960
ANY OTHER COMMENTS OR QUESTIONS?

1043
00:41:30,960 --> 00:41:31,160
OKAY.

1044
00:41:31,160 --> 00:41:33,440
NOT HEARING ANY, I'D LIKE TO

1045
00:41:33,440 --> 00:41:35,000
THEN CONTINUE.

1046
00:41:35,000 --> 00:41:37,880
JUST TO KEEP EVERYONE INFORMED,

1047
00:41:37,880 --> 00:41:43,120
OUR NEXT COUNCIL DATE IS ON MAY

1048
00:41:43,120 --> 00:41:47,080
10 AND 11, THAT IS 2022.

1049
00:41:47,080 --> 00:41:51,480
WE AT THIS POINT DON'T KNOW IF

1050
00:41:51,480 --> 00:41:52,760
THAT WILL BE AN IN-PERSON

1051
00:41:52,760 --> 00:41:55,480
MEETING OR A VIRTUAL MEETING,

1052
00:41:55,480 --> 00:41:56,480
BUT WE'RE HOPEFUL.

1053
00:41:56,480 --> 00:41:58,440
AND WE'LL LET YOU KNOW AS SOON

1054
00:41:58,440 --> 00:42:00,200
AS WE HEAR MORE INFORMATION.

1055
00:42:00,200 --> 00:42:03,160
AND THEN OF COURSE YOU CAN SEE

1056
00:42:03,160 --> 00:42:06,840
ON THE SLIDE THE OTHER FUTURE

1057
00:42:06,840 --> 00:42:08,280
DATES FOR OUR COUNCIL MEETINGS.

1058
00:42:08,280 --> 00:42:11,320
THE NEXT ITEM ON OUR AGENDA IS

1059
00:42:11,320 --> 00:42:13,720
CONSIDERATION OF THE MINUTES OF

1060
00:42:13,720 --> 00:42:14,760
THE LAST MEETING.

1061
00:42:14,760 --> 00:42:19,680
I JUST WANTED TO GET A MOTION

1062
00:42:19,680 --> 00:42:21,400
FROM OUR COUNCIL MEMBERS TO

1063
00:42:21,400 --> 00:42:25,280
APPROVE THE MINUTES FROM THE

1064
00:42:25,280 --> 00:42:25,880
LAST MEETING.

1065
00:42:25,880 --> 00:42:28,520
>> SO MOVED.

1066
00:42:28,520 --> 00:42:28,840
>> SECOND?

1067
00:42:28,840 --> 00:42:30,280
>>  SECOND.

1068
00:42:30,280 --> 00:42:30,960
>> ALL IN FAVOR?

1069
00:42:30,960 --> 00:42:32,440
>>  AYE.

1070
00:42:32,440 --> 00:42:35,120
>> AYE.

1071
00:42:35,120 --> 00:42:35,400
>> AYE.

1072
00:42:35,400 --> 00:42:35,800
>> ANY DISSENT?

1073
00:42:35,800 --> 00:42:37,040
THANK YOU VERY MUCH.

1074
00:42:37,040 --> 00:42:38,720
WE HAVE APPROVAL OF THE MINUTES

1075
00:42:38,720 --> 00:42:41,880
FROM OUR LAST MEETING.

1076
00:42:41,880 --> 00:42:42,920
THANK YOU.

1077
00:42:42,920 --> 00:42:45,000
NEXT UP IS OUR REPORT FROM OUR

1078
00:42:45,000 --> 00:42:47,720
TASK FORCE ON MINORITY AGING

1079
00:42:47,720 --> 00:42:48,120
RESEARCH.

1080
00:42:48,120 --> 00:42:56,080
I'LL TURN IT OVER TO DOCTORS

1081
00:42:56,080 --> 00:42:57,040
WHITFIELD AND MANLEY.

1082
00:42:57,040 --> 00:42:57,800
>> THANK YOU.

1083
00:42:57,800 --> 00:42:59,400
PARTICULARLY GOOD MORNING TO THE

1084
00:42:59,400 --> 00:43:00,200
NEW MEMBERS.

1085
00:43:00,200 --> 00:43:04,120
I THINK THAT ONE  OF THE THINGS

1086
00:43:04,120 --> 00:43:05,880
YOU'LL SEE THE TASK FORCE KICKS

1087
00:43:05,880 --> 00:43:07,160
OFF OUR MEETINGS ALL THE TIME.

1088
00:43:07,160 --> 00:43:12,640
OUR GOAL IS TO BE ABLE TO HAVE

1089
00:43:12,640 --> 00:43:14,400
SOME INTERESTING CHALLENGING

1090
00:43:14,400 --> 00:43:15,240
CONTROVERSIAL THOUGHT-PROVOKING

1091
00:43:15,240 --> 00:43:16,880
IDEAS THAT COME ACROSS TO BE

1092
00:43:16,880 --> 00:43:19,400
ABLE TO THINK ABOUT HOW AS PART

1093
00:43:19,400 --> 00:43:22,120
OF NIA'S MISSION WE CAN BE ABLE

1094
00:43:22,120 --> 00:43:24,080
TO ADVANCE WORK ON MINORITY

1095
00:43:24,080 --> 00:43:24,880
AGING RESEARCH.

1096
00:43:24,880 --> 00:43:27,640
SO JUST TO GIVE A VERY QUICK

1097
00:43:27,640 --> 00:43:31,680
RECAP, WE KICKED OFF YET WITH

1098
00:43:31,680 --> 00:43:33,680
DR. JONES' OPENING, AND STARTING

1099
00:43:33,680 --> 00:43:36,680
OFF BY INTRODUCING THE NEW

1100
00:43:36,680 --> 00:43:38,000
CO-CHAIR.

1101
00:43:38,000 --> 00:43:43,160
I WANT TO GIVE ALL THANKS AND

1102
00:43:43,160 --> 00:43:44,960
APPRECIATION TO JENNIFER FOR

1103
00:43:44,960 --> 00:43:46,080
STEPPING INTO THIS ROLE.

1104
00:43:46,080 --> 00:43:49,800
I THINK THAT IT'S CRITICALLY

1105
00:43:49,800 --> 00:43:51,560
IMPORTANT AND I THINK SHE'S

1106
00:43:51,560 --> 00:43:53,080
GOING TO DO AN INCREDIBLE JOB.

1107
00:43:53,080 --> 00:43:55,200
I THINK I'VE ONLY BEEN A

1108
00:43:55,200 --> 00:43:59,120
CO-CHAIR FOR LIKE A YEAR, ON MY

1109
00:43:59,120 --> 00:43:59,840
SECOND PERSON.

1110
00:43:59,840 --> 00:44:03,400
MAYBE I'M JUST WEARING THEM

1111
00:44:03,400 --> 00:44:03,720
DOWN.

1112
00:44:03,720 --> 00:44:06,640
 A SPECIAL THANKS TO CLIFF

1113
00:44:06,640 --> 00:44:07,440
ROSEN.

1114
00:44:07,440 --> 00:44:10,280
HIS THOUGHTFUL, MEANINGFUL, 

1115
00:44:10,280 --> 00:44:15,080
HEARTFUL APPRECIATION FOR THE 

1116
00:44:15,080 --> 00:44:16,160
CONTRIBUTION OF HEALTH

1117
00:44:16,160 --> 00:44:19,760
DISPARITIES AND MINORITY AGING

1118
00:44:19,760 --> 00:44:23,280
IS CRITICAL IMPORTANT. 

1119
00:44:23,280 --> 00:44:24,880
DR. JONES PROVIDED

1120
00:44:24,880 --> 00:44:28,680
ANNOUNCEMENTS, FIRST OFF 2022

1121
00:44:28,680 --> 00:44:30,720
BUTLER-WILLIAMS SCHOLAR PROGRAM,

1122
00:44:30,720 --> 00:44:35,440
MEETING AUGUST  23-25.

1123
00:44:35,440 --> 00:44:37,720
DR. JONES HAS BEEN ABLE TO RUN

1124
00:44:37,720 --> 00:44:38,680
THAT PROGRAM VIRTUALLY.

1125
00:44:38,680 --> 00:44:42,080
I KNOW SOME OF YOU, LIKE ME,

1126
00:44:42,080 --> 00:44:43,480
PARTICIPATED IN THE SUMMER

1127
00:44:43,480 --> 00:44:46,360
INSTITUTE PROGRAM OVER THE

1128
00:44:46,360 --> 00:44:46,880
YEARS.

1129
00:44:46,880 --> 00:44:48,760
AND THE DYNAMIC NATURE OF IT IN

1130
00:44:48,760 --> 00:44:49,720
PERSON IS SOMETHING THAT'S

1131
00:44:49,720 --> 00:44:51,720
SPECIAL THAT ANYBODY WHO HAS

1132
00:44:51,720 --> 00:44:53,560
BEEN THROUGH IT WILL RECOUNT

1133
00:44:53,560 --> 00:44:54,160
THAT EXPERIENCE.

1134
00:44:54,160 --> 00:44:55,640
BUT I THINK SHE'S BEEN ABLE TO

1135
00:44:55,640 --> 00:44:57,600
FIGURE OUT A WAY VIRTUALLY TO BE

1136
00:44:57,600 --> 00:45:00,080
ABLE TO CAPTURE THAT SAME KIND

1137
00:45:00,080 --> 00:45:01,680
OF EXCITEMENT AND ENTHUSIASM.

1138
00:45:01,680 --> 00:45:04,200
SO PLEASE SUGGEST TO PEOPLE THEY

1139
00:45:04,200 --> 00:45:05,640
APPLY AGAIN THIS YEAR, AND SHE

1140
00:45:05,640 --> 00:45:07,880
MENTIONED IT WILL BE VIRTUAL I

1141
00:45:07,880 --> 00:45:12,080
THINK, APPLICATIONS DUE BY APRIL

1142
00:45:12,080 --> 00:45:13,120
15, 2022.

1143
00:45:13,120 --> 00:45:15,080
SHE ALSO MENTIONED THE NIH

1144
00:45:15,080 --> 00:45:20,280
OFFICE OF DIRECTOR, OFFICE OF

1145
00:45:20,280 --> 00:45:21,320
SCIENTIFIC WORKFORCE DIVERSITY

1146
00:45:21,320 --> 00:45:22,680
QUARTERLY LECTURE SERIES

1147
00:45:22,680 --> 00:45:25,920
FOSTERING COHORT RECRUITMENT

1148
00:45:25,920 --> 00:45:30,320
WILL BE A 2 1/2-DAY VIRTUE FORUM

1149
00:45:30,320 --> 00:45:31,080
FEBRUARY 23-24, REGISTRATION

1150
00:45:31,080 --> 00:45:32,080
ANNOUNCED HOPEFULLY SOON BECAUSE

1151
00:45:32,080 --> 00:45:35,360
THAT'S COMING UP REAL SOON.

1152
00:45:35,360 --> 00:45:38,080
SHE ALSO MENTIONED REISSUING OF

1153
00:45:38,080 --> 00:45:40,160
NIH COMMON FUND, WHICH IS

1154
00:45:40,160 --> 00:45:41,480
TRANSFORMATIVE RESEARCH TO

1155
00:45:41,480 --> 00:45:44,000
ADDRESS HEALTH DISPARITIES AND

1156
00:45:44,000 --> 00:45:45,640
ADVANCE HEALTH EQUITY AT

1157
00:45:45,640 --> 00:45:50,040
MINORITY SERVING INSTITUTIONS 

1158
00:45:50,040 --> 00:45:53,080
WITH PROPOSED MARCH 25, 2022,

1159
00:45:53,080 --> 00:45:53,480
APPLICATION DATE.

1160
00:45:53,480 --> 00:45:59,680
I THINK -- I DON'T KNOW IF WE

1161
00:45:59,680 --> 00:46:06,120
HAVE HBCUs OR MINORITY SERVING

1162
00:46:06,120 --> 00:46:07,360
INSTITUTIONS REPRESENTED HERE

1163
00:46:07,360 --> 00:46:08,680
BUT WE NEED TO REACH OUT AND

1164
00:46:08,680 --> 00:46:11,960
MAKE SURE THEY ARE AWARE OF THIS

1165
00:46:11,960 --> 00:46:12,960
FUNDING OPPORTUNITY.

1166
00:46:12,960 --> 00:46:14,600
SO NEXT WE DID TWO

1167
00:46:14,600 --> 00:46:17,240
PRESENTATIONS, I'M GOING TO

1168
00:46:17,240 --> 00:46:20,720
PREVENT THEM OUT -- PRESENT THEM

1169
00:46:20,720 --> 00:46:23,120
OUT OF ORDER FOR CONVENIENCE,

1170
00:46:23,120 --> 00:46:25,080
MINE WAS SECOND, A PRESENTATION

1171
00:46:25,080 --> 00:46:29,480
I DID WAS SECOND, AND BUT I'M 

1172
00:46:29,480 --> 00:46:31,440
GOING TO SHARE WITH YOU THAT

1173
00:46:31,440 --> 00:46:33,840
HERE FIRST AND GIVE YOU A QUICK

1174
00:46:33,840 --> 00:46:35,480
RECAP, HOPEFULLY MITTING MOST OF

1175
00:46:35,480 --> 00:46:37,240
THE IMPORTANT HIGHLIGHTS.

1176
00:46:37,240 --> 00:46:39,520
SO, THE PRESENTATION WAS ON

1177
00:46:39,520 --> 00:46:41,280
CONTRASTING WITHIN AND BETWEEN

1178
00:46:41,280 --> 00:46:42,360
ANALYSES IN PURSUIT OF

1179
00:46:42,360 --> 00:46:43,880
UNDERSTANDING RACIAL DIFFERENCES

1180
00:46:43,880 --> 00:46:45,080
IN AGING POPULATIONS.

1181
00:46:45,080 --> 00:46:49,080
I PROVIDED WITH YOU THE IDEA

1182
00:46:49,080 --> 00:46:53,080
THAT SOMETIMES I THINK WE THINK

1183
00:46:53,080 --> 00:46:54,080
ABOUT AGING RESEARCH, RELATIVE

1184
00:46:54,080 --> 00:46:56,680
TO DOING WHAT WE THINK IS MAYBE

1185
00:46:56,680 --> 00:46:58,680
MORALLY RIGHT.

1186
00:46:58,680 --> 00:46:59,480
BUT ACTUALLY SCIENTIFICALLY

1187
00:46:59,480 --> 00:47:02,480
RIGHT IS AN ISSUE THAT WE NEED

1188
00:47:02,480 --> 00:47:03,920
TO THINK ABOUT.

1189
00:47:03,920 --> 00:47:05,240
CULTURE ACTUALLY IMPACTS EVERY

1190
00:47:05,240 --> 00:47:09,720
STEP OF THE SCIENTIFIC PROCESS.

1191
00:47:09,720 --> 00:47:12,080
QUESTIONS, MODELS, TO

1192
00:47:12,080 --> 00:47:13,720
MEASUREMENT, TO ANALYSIS, EVEN

1193
00:47:13,720 --> 00:47:14,240
INTERPRETATION.

1194
00:47:14,240 --> 00:47:17,800
AND SO JUST TO PROVIDE A QUICK

1195
00:47:17,800 --> 00:47:19,440
SUMMARY, I TALKED ABOUT BETWEEN

1196
00:47:19,440 --> 00:47:21,480
GROUP QUESTIONS, I WANTED TO

1197
00:47:21,480 --> 00:47:25,240
MAKE IT CLEAR I SPENT MY CAREER

1198
00:47:25,240 --> 00:47:29,040
IN RESEARCH, I'M NOT AGAINST

1199
00:47:29,040 --> 00:47:31,560
BETWEEN GROUP BUT HAVE TO BE

1200
00:47:31,560 --> 00:47:32,280
THOUGHTFUL, WHAT FACTORS ACCOUNT

1201
00:47:32,280 --> 00:47:35,040
FOR DIFFERENCE.

1202
00:47:35,040 --> 00:47:38,280
I USED THE EXAMPLE OF COGNITIVE

1203
00:47:38,280 --> 00:47:40,400
PERFORMANCE BUT APPLIES TO

1204
00:47:40,400 --> 00:47:44,120
ANYTHING, PUT IN DIFFERENCES IN,

1205
00:47:44,120 --> 00:47:45,520
YOU KNOW, BIOINFORMATICS OR

1206
00:47:45,520 --> 00:47:46,880
WHATEVER AS A FACTOR.

1207
00:47:46,880 --> 00:47:49,480
ALSO ASKING QUESTIONS LIKE ARE

1208
00:47:49,480 --> 00:47:51,040
THERE DIFFERENCES IN COGNITIVE

1209
00:47:51,040 --> 00:47:52,320
PERFORMANCE BY RACE.

1210
00:47:52,320 --> 00:47:54,200
BUT THERE ARE ALSO VERY VALID

1211
00:47:54,200 --> 00:47:57,560
AND VERY USEFUL AND VERY

1212
00:47:57,560 --> 00:48:01,480
IMPORTANT IN-GROUP QUESTIONS.

1213
00:48:01,480 --> 00:48:02,480
WHAT ACCOUNTS VARIABILITY IN

1214
00:48:02,480 --> 00:48:03,680
COGNITIVE FUNCTION IN AFRICAN

1215
00:48:03,680 --> 00:48:05,000
AMERICANS, WHAT MAKES AFRICAN

1216
00:48:05,000 --> 00:48:06,320
AMERICANS AND CAUCASIANS

1217
00:48:06,320 --> 00:48:07,480
DIFFERENT IN COGNITIVE

1218
00:48:07,480 --> 00:48:08,960
FUNCTIONING AND WHY?

1219
00:48:08,960 --> 00:48:11,280
THAT'S A BIT OF A GROUP APPROACH

1220
00:48:11,280 --> 00:48:12,640
IN A MODIFIED SORT OF WAY

1221
00:48:12,640 --> 00:48:14,280
BECAUSE YOU'RE TRYING TO FIGURE

1222
00:48:14,280 --> 00:48:16,680
OUT WHAT THE EXPLANATORY FACTOR

1223
00:48:16,680 --> 00:48:17,760
IS BETWEEN THE TWO.

1224
00:48:17,760 --> 00:48:19,280
SO THAT'S AN IMPORTANT STEP TO

1225
00:48:19,280 --> 00:48:20,480
MAKE AS WELL.

1226
00:48:20,480 --> 00:48:24,760
I DID TALK ABOUT MODELS OF

1227
00:48:24,760 --> 00:48:27,600
CULTURAL DIFFERENCES CITING A

1228
00:48:27,600 --> 00:48:29,920
PAPER, I PROVIDED A 2008 PAPER I

1229
00:48:29,920 --> 00:48:32,080
HAVE, AS I OFTEN DO, I ASK

1230
00:48:32,080 --> 00:48:33,280
EVERYBODY TRY TO CITE THAT PAPER

1231
00:48:33,280 --> 00:48:38,080
SO I CAN GET MY CITATION IN,

1232
00:48:38,080 --> 00:48:40,920
IT'S ONE I HOPE THAT'S IMPORTANT

1233
00:48:40,920 --> 00:48:42,040
AND THOUGHT PROVOKING, TALKS

1234
00:48:42,040 --> 00:48:43,880
ABOUT WAYS WE AS SCIENTISTS

1235
00:48:43,880 --> 00:48:45,520
THINK ABOUT CULTURAL DIFFERENCE.

1236
00:48:45,520 --> 00:48:49,920
I TALK ABOUT ANALYSES AND TALK 

1237
00:48:49,920 --> 00:48:51,440
ABOUT POWER CALCULATIONS, THERE

1238
00:48:51,440 --> 00:48:53,280
ARE POWER CURVES IN THAT PAPER.

1239
00:48:53,280 --> 00:48:54,880
THE MOST IMPORTANT PIECE, THE

1240
00:48:54,880 --> 00:48:55,960
LARGER THE DIFFERENCE BETWEEN

1241
00:48:55,960 --> 00:48:58,360
THE TWO GROUPS, THE LARGER THE

1242
00:48:58,360 --> 00:49:02,600
SAMPLE SIZES OVERALL NEED TO BE

1243
00:49:02,600 --> 00:49:04,360
TO GET PROPER POWER ESTIMATION.

1244
00:49:04,360 --> 00:49:06,840
ALSO MENTIONED A BIT ABOUT

1245
00:49:06,840 --> 00:49:08,920
INTERPRETATIONS THAT DIFFERENCES

1246
00:49:08,920 --> 00:49:10,680
CAN BE STRENGTH, TRAJECTORIES OF

1247
00:49:10,680 --> 00:49:12,520
CHANGE MY BE DIFFERENT.

1248
00:49:12,520 --> 00:49:15,080
SO AS IS A MAIN GOAL OF MUCH OF

1249
00:49:15,080 --> 00:49:17,320
WHAT WE TRY TO DO IN THE SCIENCE

1250
00:49:17,320 --> 00:49:18,960
OF AGING, TRYING TO GET

1251
00:49:18,960 --> 00:49:20,080
LONGITUDINAL STUDIES, SO THAT WE

1252
00:49:20,080 --> 00:49:21,920
DON'T JUST GET THE PSYCHOLOGICAL

1253
00:49:21,920 --> 00:49:24,760
MOMENT IN ONE MOMENT IN TIME.

1254
00:49:24,760 --> 00:49:25,680
WE GET TRAJECTORIES, PROCESSES

1255
00:49:25,680 --> 00:49:28,000
OF CHANGE CAN BE IDENTIFIED.

1256
00:49:28,000 --> 00:49:29,880
THOSE ARE THINGS THAT ARE VERY

1257
00:49:29,880 --> 00:49:31,080
IMPORTANT FOR LONGITUDINAL

1258
00:49:31,080 --> 00:49:45,680
STUDIES TO BE DONE, BOTH WITHIN 

1259
00:49:45,680 --> 00:49:46,800
AND BETWEEN.

1260
00:49:46,800 --> 00:49:49,480
LASTLY, FOR BASIC AND APPLIES,

1261
00:49:49,480 --> 00:49:51,040
IF YOU HAVE PHENOMENA THAT ARE

1262
00:49:51,040 --> 00:49:53,880
IMPACTED BY SOCIAL AND

1263
00:49:53,880 --> 00:49:54,520
PSYCHOLOGICAL FACTORS, BUT

1264
00:49:54,520 --> 00:49:55,720
WIN-GROUP APPROACH IS VERY

1265
00:49:55,720 --> 00:50:00,320
USEFUL TO BE ABLE --

1266
00:50:00,320 --> 00:50:02,080
WITHIN-GROUP APPROACH IS USEFUL

1267
00:50:02,080 --> 00:50:04,280
TO IDENTIFY WHAT CAUSES

1268
00:50:04,280 --> 00:50:05,480
VARIABILITY, THAT MAY CAUSE

1269
00:50:05,480 --> 00:50:07,040
POPULATION VARIABILITY AS WE

1270
00:50:07,040 --> 00:50:11,000
LOOK AT SUBPOPULATIONS.

1271
00:50:11,000 --> 00:50:11,680
FUTURE RESEARCH UTILIZING

1272
00:50:11,680 --> 00:50:13,560
MINORITIES FOR UNDERSTANDING

1273
00:50:13,560 --> 00:50:14,400
RESEARCH AND DYSFUNCTION WILL,

1274
00:50:14,400 --> 00:50:17,840
IN MY THOUGHT, BE ABLE TO

1275
00:50:17,840 --> 00:50:19,200
ADVANCE SCIENCE AND AGING IN

1276
00:50:19,200 --> 00:50:19,440
GENERAL.

1277
00:50:19,440 --> 00:50:27,280
I GAVE THE EXAMPLE OF STUDYING 

1278
00:50:27,280 --> 00:50:29,520
LONGEVITY IN AFRICAN AMERICANS.

1279
00:50:29,520 --> 00:50:33,920
SELF SERVING BUT IF WE LOOK AT A

1280
00:50:33,920 --> 00:50:34,800
GROUP, ALMOST DOING EXTREMES

1281
00:50:34,800 --> 00:50:37,160
ANALYSIS THINKING ABOUT FOLKS

1282
00:50:37,160 --> 00:50:38,880
WHO ARE AT THE VERY EXTREMES FOR

1283
00:50:38,880 --> 00:50:40,160
A PARTICULAR REASON FOR AFRICAN

1284
00:50:40,160 --> 00:50:41,920
AMERICANS BECAUSE OF THE EARLY

1285
00:50:41,920 --> 00:50:46,400
MORTALITY AND SHORTER LIFE

1286
00:50:46,400 --> 00:50:49,480
EXPECTANCY, THOSE WHO LIVE VERY

1287
00:50:49,480 --> 00:50:50,720
LONG LIVES REPRESENT EXTREME

1288
00:50:50,720 --> 00:50:51,880
SITUATIONS OF AGING.

1289
00:50:51,880 --> 00:50:53,840
SO THEY MILD PROVIDE SOME

1290
00:50:53,840 --> 00:50:54,840
INTERESTING INSIGHTS, IF WE

1291
00:50:54,840 --> 00:50:57,560
LEARN ABOUT THEM.

1292
00:50:57,560 --> 00:50:59,520
LASTLY, ALTERNATIVE STRATEGIES

1293
00:50:59,520 --> 00:51:01,160
FOR STUDYING MINORITIES, DOING

1294
00:51:01,160 --> 00:51:03,560
BETWEEN AND WITHIN, WILL HELP

1295
00:51:03,560 --> 00:51:05,520
ADVANCE OUR UNDERSTANDING OF

1296
00:51:05,520 --> 00:51:10,080
MINORITIES AND PEOPLE, AND ALL

1297
00:51:10,080 --> 00:51:12,920
PEOPLE. 

1298
00:51:12,920 --> 00:51:16,000
SO THAT WAS MY PRESENTATION, THE

1299
00:51:16,000 --> 00:51:18,280
FIRST PRESENTATION WAS ACTUALLY

1300
00:51:18,280 --> 00:51:21,480
BY DR. WASHINGTON AND DR. MANLY

1301
00:51:21,480 --> 00:51:23,520
IS GOING TO PROVIDE AN OVERVIEW

1302
00:51:23,520 --> 00:51:26,360
OF HER PRESENTATION.

1303
00:51:26,360 --> 00:51:30,880
>> THANK YOU, DR. WHITFIELD, AND

1304
00:51:30,880 --> 00:51:32,000
PRESIDENT WHITFIELD.

1305
00:51:32,000 --> 00:51:35,560
I'LL GIVE A TWO OR THREE-MINUTE

1306
00:51:35,560 --> 00:51:37,240
OVERVIEW OF OR EXCELLENT TALK BY

1307
00:51:37,240 --> 00:51:37,760
DR. WASHINGTON.

1308
00:51:37,760 --> 00:51:39,720
DONNA WASHINGTON IS THE DIRECTOR

1309
00:51:39,720 --> 00:51:48,800
OF THE OFFICE OF HEALTH EQUITY,

1310
00:51:48,800 --> 00:51:49,640
AND QUALITY ENHANCEMENT CENTER

1311
00:51:49,640 --> 00:51:50,760
AT THE V.A.

1312
00:51:50,760 --> 00:51:55,880
THE TALK SHE GAVE TO US WAS A

1313
00:51:55,880 --> 00:51:58,400
REPORT ESSENTIALLY FROM THE

1314
00:51:58,400 --> 00:52:00,000
NATIONAL VETERANS HEALTH EQUITY

1315
00:52:00,000 --> 00:52:03,360
REPORT THEY RUN REGULARLY AT THE

1316
00:52:03,360 --> 00:52:05,240
V.A.

1317
00:52:05,240 --> 00:52:08,880
AND THE PURPOSE WAS OF THESE 

1318
00:52:08,880 --> 00:52:13,480
REPORTS IS TO GO OVER THE STATUS

1319
00:52:13,480 --> 00:52:17,080
OF HEALTH EQUITY AT THE V.A. AND

1320
00:52:17,080 --> 00:52:22,880
V.A. HEALTH SYSTEM, AND SHE GAVE

1321
00:52:22,880 --> 00:52:24,480
A VERY USEFUL DEFINITION OF

1322
00:52:24,480 --> 00:52:26,720
HEALTH EQUITY, WHICH IS THE

1323
00:52:26,720 --> 00:52:40,080
ABSENCE OF UNFAIR AND AVOIDABLE

1324
00:52:40,080 --> 00:52:42,280
OR REMEDIABLE SITUATIONS,

1325
00:52:42,280 --> 00:52:43,480
DEFINED BY OTHER GROUP

1326
00:52:43,480 --> 00:52:44,440
DEFINITIONS.

1327
00:52:44,440 --> 00:52:46,200
AND THIS IS A W.H.O. DEFINITION

1328
00:52:46,200 --> 00:52:47,640
OF HEALTH EQUITY.

1329
00:52:47,640 --> 00:52:50,800
SO YOU CAN SEE HER REPORT

1330
00:52:50,800 --> 00:52:52,960
ORGANIZED AROUND THIS.

1331
00:52:52,960 --> 00:52:54,280
THE UNDERLYING PURPOSE REALLY

1332
00:52:54,280 --> 00:52:55,880
SEEMED TO BE, OF THESE REPORTS,

1333
00:52:55,880 --> 00:52:57,880
THAT YOU CAN ONLY CHANGE WHAT

1334
00:52:57,880 --> 00:52:58,880
YOU MEASURE.

1335
00:52:58,880 --> 00:53:00,080
AND THAT INCREASING KNOWLEDGE

1336
00:53:00,080 --> 00:53:03,240
AND AWARENESS OF THE STATE OF

1337
00:53:03,240 --> 00:53:06,800
HEALTH EQUITY AT THE V.A.

1338
00:53:06,800 --> 00:53:11,720
PROVIDES THE EVIDENCE BASE FOR

1339
00:53:11,720 --> 00:53:12,920
FIGURING OUT BARRIERS AND

1340
00:53:12,920 --> 00:53:15,440
RECOMMEND ACTIONS FOR IMPROVING

1341
00:53:15,440 --> 00:53:18,480
HEALTH EQUITY SYSTEMWIDE.

1342
00:53:18,480 --> 00:53:21,240
DR. WASHINGTON PROVIDED SOME

1343
00:53:21,240 --> 00:53:22,480
DEMOGRAPHICS OF THE PATIENT

1344
00:53:22,480 --> 00:53:24,280
GROUP AT THE V.A.

1345
00:53:24,280 --> 00:53:27,360
AND I'VE GOT A SCREEN SHOT

1346
00:53:27,360 --> 00:53:28,560
THERE, JUST INCIDENTALLY THIS

1347
00:53:28,560 --> 00:53:30,280
REPORT YOU CAN GOOGLE IT.

1348
00:53:30,280 --> 00:53:31,400
IT'S ONLINE.

1349
00:53:31,400 --> 00:53:35,200
AND YOU CAN GO THROUGH EXTREMELY

1350
00:53:35,200 --> 00:53:36,960
DETAILED AND SEE ALL THESE

1351
00:53:36,960 --> 00:53:38,560
TABLES AND GRAPHS I'LL FLASH BY

1352
00:53:38,560 --> 00:53:42,120
VERY QUICKLY ON THE REPORT.

1353
00:53:42,120 --> 00:53:46,280
THAT'S MEANT TO SAY 2021, BY THE

1354
00:53:46,280 --> 00:53:46,560
WAY.

1355
00:53:46,560 --> 00:53:48,240
THE FOCUS IN 2021 IN THEIR

1356
00:53:48,240 --> 00:53:51,520
EQUITY REPORT ON PATIENT

1357
00:53:51,520 --> 00:53:54,600
EXPERIENCES OF CARE, WITH SORT

1358
00:53:54,600 --> 00:53:57,080
OF A PATIENT-CENTERED CARE, AND

1359
00:53:57,080 --> 00:53:59,480
ALSO HEALTH CARE QUALITY.

1360
00:53:59,480 --> 00:54:03,080
THEY DEFINED DISPARITIES BOTH

1361
00:54:03,080 --> 00:54:06,200
USING AN ABSOLUTE METRIC, WHICH

1362
00:54:06,200 --> 00:54:07,160
IS STATISTICAL SIGNIFICANCE

1363
00:54:07,160 --> 00:54:09,880
METRIC BETWEEN TWO GROUPS.

1364
00:54:09,880 --> 00:54:11,680
AND ALSO A RELATIVE, HAVING A

1365
00:54:11,680 --> 00:54:15,160
RELATIVE DIFFERENCE OF AT LEAST

1366
00:54:15,160 --> 00:54:17,440
10%, SO THE DIAGNOSED PREVALENCE

1367
00:54:17,440 --> 00:54:20,040
OF A CONDITION OR HEALTH CARE

1368
00:54:20,040 --> 00:54:22,000
DIFFERENCE IN A GROUP WAS 10% OR

1369
00:54:22,000 --> 00:54:23,640
HIGHER THAN IT IS IN THE

1370
00:54:23,640 --> 00:54:26,080
REFERENCE GROUP, IS HOW THE

1371
00:54:26,080 --> 00:54:29,880
RELATIVE DIFFERENCE WAS DEFINED.

1372
00:54:29,880 --> 00:54:33,680
AND WHAT YOU CAN SEE, JUST BY

1373
00:54:33,680 --> 00:54:35,560
SQUINTING ON THE GRAPH, OR THE

1374
00:54:35,560 --> 00:54:39,480
FIGURE IN THIS SLIDE, IS THAT

1375
00:54:39,480 --> 00:54:40,880
THERE WAS GREATER RACIAL AND

1376
00:54:40,880 --> 00:54:44,400
ETHNIC DIVERSITY AMONG VETERANS

1377
00:54:44,400 --> 00:54:47,480
YOUNGER THAN 65, AND THEY FOUND

1378
00:54:47,480 --> 00:54:49,520
58% OF THE PATIENTS IN THE

1379
00:54:49,520 --> 00:54:51,480
SYSTEM HAD A SERVICE-CONNECTED

1380
00:54:51,480 --> 00:54:53,920
DISABILITY, SO JUST TO QUICKLY

1381
00:54:53,920 --> 00:54:56,280
SHOW YOU A FEW OF THE SLIDES

1382
00:54:56,280 --> 00:54:57,720
THAT DR. WASHINGTON SHOWED US,

1383
00:54:57,720 --> 00:55:02,880
THERE WAS A LOT OF DATA THERE,

1384
00:55:02,880 --> 00:55:04,480
REALLY IMPRESSIVE, IN THE FIRST

1385
00:55:04,480 --> 00:55:10,640
SLIDE ON THE UPPER LEFT I'M

1386
00:55:10,640 --> 00:55:12,560
SHOWING THE DIFFERENCES IN THE

1387
00:55:12,560 --> 00:55:14,080
PATIENTS WHO INDICATED THAT IN

1388
00:55:14,080 --> 00:55:16,360
THE LAST SIX MONTHS THEIR

1389
00:55:16,360 --> 00:55:17,080
PROVIDER ALWAYS SPENT ENOUGH

1390
00:55:17,080 --> 00:55:17,800
TIME WITH THEM.

1391
00:55:17,800 --> 00:55:22,400
SO THIS IS SOMETHING YOU WANT A

1392
00:55:22,400 --> 00:55:23,360
LOT OF.

1393
00:55:23,360 --> 00:55:27,520
AND THE REFERENCE IS THAT 

1394
00:55:27,520 --> 00:55:35,280
PATIENTS IN THE CORRESPONDING

1395
00:55:35,280 --> 00:55:38,240
AGE GROUP, NON-HISPANIC WHITE

1396
00:55:38,240 --> 00:55:38,560
VETERANS.

1397
00:55:38,560 --> 00:55:40,080
RED BARS, THE GROUP WAS WORSE

1398
00:55:40,080 --> 00:55:41,880
THAN REFERENCE GROUP, IN YELLOW

1399
00:55:41,880 --> 00:55:43,120
THE SAME AS REFERENCE GROUP.

1400
00:55:43,120 --> 00:55:49,680
WHAT YOU CAN SEE IS THAT IN

1401
00:55:49,680 --> 00:55:51,560
ESPECIALLY MIDDLE AND OLDER AGE

1402
00:55:51,560 --> 00:55:57,880
GROUPS MANY ETHNICITY  -- ETHNIC

1403
00:55:57,880 --> 00:55:59,960
AND RACIAL GROUPS FEWER FELT THE

1404
00:55:59,960 --> 00:56:00,960
PROVIDER WAS SPENDING ENOUGH

1405
00:56:00,960 --> 00:56:04,040
TIME WITH THEM.

1406
00:56:04,040 --> 00:56:06,840
LOWER RIGHT I'M SHOWING

1407
00:56:06,840 --> 00:56:09,080
DIFFERENCES IN THE PATIENTS WHO

1408
00:56:09,080 --> 00:56:11,720
SAID THEIR PROVIDER ASKED THEM

1409
00:56:11,720 --> 00:56:14,040
IF THERE WAS A PERIOD OF TIME

1410
00:56:14,040 --> 00:56:16,560
THEY FELT SAD, EMPTY, DEPRESSED.

1411
00:56:16,560 --> 00:56:20,280
HERE THE REFERENCE GROUP IS HIGH

1412
00:56:20,280 --> 00:56:29,040
SES PEOPLE FINDING A DISPARITY

1413
00:56:29,040 --> 00:56:31,080
HERE, EVEN ACROSS EACH AGE

1414
00:56:31,080 --> 00:56:31,280
GROUP.

1415
00:56:31,280 --> 00:56:34,120
IN GENERAL FREQUENCY OF THE

1416
00:56:34,120 --> 00:56:34,920
PROVIDERS ASKING ABOUT

1417
00:56:34,920 --> 00:56:38,080
DEPRESSION WAS LOWER AS PEOPLE

1418
00:56:38,080 --> 00:56:40,280
IN THE VHA FELT HEALTH SYSTEM

1419
00:56:40,280 --> 00:56:43,280
GOT OLDER.

1420
00:56:43,280 --> 00:56:47,880
SO IN SUMMARY, DR. WASHINGTON 

1421
00:56:47,880 --> 00:56:49,280
SHOWED US MANY DISPARITIES IN

1422
00:56:49,280 --> 00:56:53,120
THE V.A. HEALTH SYSTEM IN

1423
00:56:53,120 --> 00:56:54,720
PERSON-CENTERED CARE, ACCESS TO

1424
00:56:54,720 --> 00:56:56,280
CARE, CARE COORDINATION.

1425
00:56:56,280 --> 00:56:58,080
DIFFERENCES BY RACE AND

1426
00:56:58,080 --> 00:56:58,600
ETHNICITY.

1427
00:56:58,600 --> 00:57:02,640
THERE WERE DIFFERENCES BY SES,

1428
00:57:02,640 --> 00:57:07,200
DIFFERENCES BY SEX/GENDER, AND

1429
00:57:07,200 --> 00:57:10,280
DIFFERENCES BY HEALTH, BY

1430
00:57:10,280 --> 00:57:11,120
SERVICE-CONNECTED DISABILITY.

1431
00:57:11,120 --> 00:57:14,680
THE PURPOSE OF THE ANALYSES THAT

1432
00:57:14,680 --> 00:57:15,880
DR. WASHINGTON HELPED US

1433
00:57:15,880 --> 00:57:17,640
UNDERSTAND IS TO IMPROVE THE

1434
00:57:17,640 --> 00:57:19,120
CARE OF ALL VETERANS

1435
00:57:19,120 --> 00:57:21,320
EXPERIENCING DISPARATE CARE OR

1436
00:57:21,320 --> 00:57:23,200
OUTCOMES, AND THE REPORT REALLY

1437
00:57:23,200 --> 00:57:28,000
WAS -- IS INTENDED TO RAISE

1438
00:57:28,000 --> 00:57:29,480
AWARENESS, AND TO BOLSTER

1439
00:57:29,480 --> 00:57:31,000
ACTION, IN IMPROVING THE LIVES

1440
00:57:31,000 --> 00:57:32,480
AND HEALTH CARE OF VETERANS.

1441
00:57:32,480 --> 00:57:34,640
I THINK THE WAY WE WERE SHOWN

1442
00:57:34,640 --> 00:57:38,480
THESE DATA IS A REALLY NICE

1443
00:57:38,480 --> 00:57:40,240
TEMPLATE OR EXAMPLE OF THE

1444
00:57:40,240 --> 00:57:43,520
EXTENT OF DATA COLLECTION NEEDED

1445
00:57:43,520 --> 00:57:46,040
TO ANALYZE, DESIGN, AND GENERATE

1446
00:57:46,040 --> 00:57:48,120
TOOLS AND INTERVENTIONS TO

1447
00:57:48,120 --> 00:57:49,080
NARROW DISPARITIES.

1448
00:57:49,080 --> 00:57:51,400
WE HAD A NICE DISCUSSION, A LOT

1449
00:57:51,400 --> 00:57:55,080
OF IT WAS ABOUT HIGH RATES OF

1450
00:57:55,080 --> 00:57:58,640
DEPRESSION AMONG VETERANS.

1451
00:57:58,640 --> 00:58:01,160
DR. WASHINGTON DESCRIBED, YOU

1452
00:58:01,160 --> 00:58:03,680
KNOW, AN APPROACH THAT THIS

1453
00:58:03,680 --> 00:58:06,080
REPORT POINTED TO, WHICH IS FOR

1454
00:58:06,080 --> 00:58:09,600
PROVIDERS TO REALLY ASK ABOUT

1455
00:58:09,600 --> 00:58:14,200
STRESSORS THAT THE PATIENTS ARE

1456
00:58:14,200 --> 00:58:16,480
GOING THROUGH, AND TO -- RATHER

1457
00:58:16,480 --> 00:58:17,760
THAN -- THERE MIGHT NOT BE

1458
00:58:17,760 --> 00:58:19,120
SPECIFIC ACTIONS THAT PROVIDERS

1459
00:58:19,120 --> 00:58:21,960
CAN DO BUT THEY CAN UNDERSTAND

1460
00:58:21,960 --> 00:58:23,600
WHAT THE PATIENTS ARE

1461
00:58:23,600 --> 00:58:24,160
EXPERIENCING.

1462
00:58:24,160 --> 00:58:25,800
AND THAT COMMUNICATION BETWEEN

1463
00:58:25,800 --> 00:58:27,760
PATIENTS AND PROVIDERS COULD BE

1464
00:58:27,760 --> 00:58:30,440
A KEY FOR REDUCING DISPARITIES.

1465
00:58:30,440 --> 00:58:34,880
WE ALSO HAD A QUESTION ABOUT

1466
00:58:34,880 --> 00:58:39,360
HEATHER  -- HETEROGENEITY AND

1467
00:58:39,360 --> 00:58:40,800
COMBAT VETERAN STATUS THAT DR.

1468
00:58:40,800 --> 00:58:42,240
WASHINGTON SAID IS A FUTURE GOAL

1469
00:58:42,240 --> 00:58:44,480
FOR THE RESEARCH IN THIS AREA.

1470
00:58:44,480 --> 00:58:48,040
AND THAT'S MY SUMMARY OF DR.

1471
00:58:48,040 --> 00:58:50,480
WASHINGTON'S TALK.

1472
00:58:50,480 --> 00:58:52,360
 

1473
00:58:52,360 --> 00:58:53,440
>> ANY QUESTIONS OR ANY

1474
00:58:53,440 --> 00:58:55,520
FOLLOW-UP?

1475
00:58:55,520 --> 00:59:02,320
 

1476
00:59:02,320 --> 00:59:03,640
>> WHILE WE'RE WAITING FOR

1477
00:59:03,640 --> 00:59:05,080
QUESTIONS, I WANTED TO COMMENT.

1478
00:59:05,080 --> 00:59:06,640
THE COMMENT IS OF COURSE THANKS

1479
00:59:06,640 --> 00:59:09,160
TO ALL OF YOU, THE CO-CHAIRS AND

1480
00:59:09,160 --> 00:59:10,040
MEMBERS WHO PARTICIPATED.

1481
00:59:10,040 --> 00:59:13,000
BUT JUST TO POINT OUT TO THE

1482
00:59:13,000 --> 00:59:13,560
COUNCIL, PARTICULARLY NEW

1483
00:59:13,560 --> 00:59:14,760
COUNCIL MEMBERS AND OTHERS IN

1484
00:59:14,760 --> 00:59:18,480
THE AUDIENCE WHAT AN IMPORTANT

1485
00:59:18,480 --> 00:59:21,120
AND ARGUABLY UNIQUE PART THIS IS

1486
00:59:21,120 --> 00:59:22,840
OF OUR COUNCIL AND COUNCIL

1487
00:59:22,840 --> 00:59:23,880
ACTIVITIES, THIS TASK FORCE

1488
00:59:23,880 --> 00:59:26,880
BEGAN MANY YEARS AGO WITH GIANTS

1489
00:59:26,880 --> 00:59:29,080
LIKE JAMES JACKSON BEING SOME OF

1490
00:59:29,080 --> 00:59:30,600
THE FUNDING CHAIRS, HAS

1491
00:59:30,600 --> 00:59:31,160
CONTINUED TO BE CRITICALLY

1492
00:59:31,160 --> 00:59:33,360
IMPORTANT TO MAKE SURE WE DON'T

1493
00:59:33,360 --> 00:59:35,000
LOSE FOCUS, NOW OVER YEARS AND

1494
00:59:35,000 --> 00:59:37,200
DECADES, ABOUT THIS IMPORTANT

1495
00:59:37,200 --> 00:59:37,920
ASPECT.

1496
00:59:37,920 --> 00:59:39,920
IT'S A REGULAR INTEGRAL PART OF

1497
00:59:39,920 --> 00:59:40,680
THE COUNCIL MEETINGS, WE'RE

1498
00:59:40,680 --> 00:59:42,240
EXCITED TO HAVE IT BE SO.

1499
00:59:42,240 --> 00:59:47,120
THANK UP ALL -- THANK YOU ALL

1500
00:59:47,120 --> 00:59:49,760
FOR TAKING THE LEAD IN THIS.

1501
00:59:49,760 --> 00:59:53,880
>> SO ANY QUESTIONS FOR DOCTORS 

1502
00:59:53,880 --> 01:00:00,080
WHITFIELD AND MANLY? 

1503
01:00:00,080 --> 01:00:01,520
ALL RIGHT.

1504
01:00:01,520 --> 01:00:03,680
AGAIN, THANKS TO THE TASK FORCE

1505
01:00:03,680 --> 01:00:06,680
AND THANK YOU FOR THE SUMMARY OF

1506
01:00:06,680 --> 01:00:09,600
THE TWO VERY IMPORTANT TOPICS

1507
01:00:09,600 --> 01:00:11,480
FROM DOCTORS WHITFIELD AND

1508
01:00:11,480 --> 01:00:12,120
WASHINGTON.

1509
01:00:12,120 --> 01:00:14,960
APPRECIATE THE SUMMARIES.

1510
01:00:14,960 --> 01:00:16,080
>> THANK YOU.

1511
01:00:16,080 --> 01:00:18,280
>> NEXT UP IS OUR REPORT FROM

1512
01:00:18,280 --> 01:00:20,120
THE WORKING GROUP ON PROGRAM.

1513
01:00:20,120 --> 01:00:26,680
I'LL TURN THIS OVER TO DR. 

1514
01:00:26,680 --> 01:00:28,880
MONICA DRISCOLL, OUR CHAIR.

1515
01:00:28,880 --> 01:00:30,160
>> THANKS VERY MUCH.

1516
01:00:30,160 --> 01:00:34,080
I WANTED TO START REALLY BY

1517
01:00:34,080 --> 01:00:34,680
CONGRATULATING AND THANKING

1518
01:00:34,680 --> 01:00:37,280
PROGRAM FOR ALL THE REALLY HARD

1519
01:00:37,280 --> 01:00:40,040
WORK IN DEVELOPING THESE

1520
01:00:40,040 --> 01:00:40,360
CONCEPTS.

1521
01:00:40,360 --> 01:00:43,520
AND TO THE COUNCIL MEMBERS FOR

1522
01:00:43,520 --> 01:00:46,320
THEIR TIME AND CAREFUL

1523
01:00:46,320 --> 01:00:47,120
CONSIDERATION OF WHAT HAS GONE

1524
01:00:47,120 --> 01:00:47,560
FORWARD.

1525
01:00:47,560 --> 01:00:50,200
WE HAVE A NUMBER OF CONCEPTS.

1526
01:00:50,200 --> 01:00:54,000
WE'LL START WITH THOSE FROM THE

1527
01:00:54,000 --> 01:00:55,800
DIVISION OF BEHAVIORAL AND

1528
01:00:55,800 --> 01:00:57,240
SOCIAL RESEARCH.

1529
01:00:57,240 --> 01:00:59,200
THE FIRST CONCEPT WAS -- OH, AND

1530
01:00:59,200 --> 01:01:00,920
I SHOULD -- I'M SORRY.

1531
01:01:00,920 --> 01:01:03,120
I SHOULD REMIND YOU THAT WE HAD

1532
01:01:03,120 --> 01:01:06,880
GREAT DISCUSSION OF THESE

1533
01:01:06,880 --> 01:01:09,800
PROPOSALS YESTERDAY.

1534
01:01:09,800 --> 01:01:11,800
TODAY, I'LL ANNOUNCE PRIMARY AND

1535
01:01:11,800 --> 01:01:12,920
SECOND REVIEWER, THE PRIMARY

1536
01:01:12,920 --> 01:01:14,080
WILL DO THE SUMMARY, EVERYONE

1537
01:01:14,080 --> 01:01:16,840
WILL HAVE A CHANCE TO COMMENT

1538
01:01:16,840 --> 01:01:18,720
BUT BE MORE CONCISE THAN WE WERE

1539
01:01:18,720 --> 01:01:20,120
YESTERDAY.

1540
01:01:20,120 --> 01:01:21,000
OKAY.

1541
01:01:21,000 --> 01:01:27,800
SO THE FIRST CONCEPT IS POLICY

1542
01:01:27,800 --> 01:01:30,520
IN AD/ADRD HEALTH CARE

1543
01:01:30,520 --> 01:01:31,840
DISPARITIES, ACCESS, UTILIZATION

1544
01:01:31,840 --> 01:01:32,760
AND QUALITY.

1545
01:01:32,760 --> 01:01:36,320
PRIMARY WE VIEWER DR. WHITFIELD,

1546
01:01:36,320 --> 01:01:38,640
SECONDARY WAS DR. FULLMER.

1547
01:01:38,640 --> 01:01:47,760
DR. WHITFIELD, IF YOU COULD 

1548
01:01:47,760 --> 01:01:49,040
SUMMARIZE THE DISCUSSION

1549
01:01:49,040 --> 01:01:49,280
YESTERDAY.

1550
01:01:49,280 --> 01:01:50,800
>> YOU CAUGHT ME AT A LOSS.

1551
01:01:50,800 --> 01:01:58,040
I WAS WRITING SOMETHING IN THE

1552
01:01:58,040 --> 01:01:59,680
CHAT.

1553
01:01:59,680 --> 01:02:01,640
THIS WAS ABOUT ADHD HEALTH CARE

1554
01:02:01,640 --> 01:02:02,320
DISPARITIES, ACCESS AND

1555
01:02:02,320 --> 01:02:03,000
UTILIZATION.

1556
01:02:03,000 --> 01:02:05,280
WE WERE IN GENERAL SUPPORTIVE OF

1557
01:02:05,280 --> 01:02:06,400
THIS, THINKING THAT IF THERE

1558
01:02:06,400 --> 01:02:08,720
COULD BE WAYS IN WHICH POLICY

1559
01:02:08,720 --> 01:02:10,920
COULD ADD TO THE DISCUSSION, HOW

1560
01:02:10,920 --> 01:02:12,120
HEALTH DISPARITIES ARE TAKEN

1561
01:02:12,120 --> 01:02:14,120
CARE OF, IT WOULD BE VERY

1562
01:02:14,120 --> 01:02:14,640
IMPORTANT.

1563
01:02:14,640 --> 01:02:16,400
ONE OF THE COMMENTS THAT I CAN

1564
01:02:16,400 --> 01:02:19,400
REMEMBER THAT I HAD WAS THAT

1565
01:02:19,400 --> 01:02:23,000
PERHAPS RATHER THAN JUST SIMPLY

1566
01:02:23,000 --> 01:02:24,960
USING AN R01 MECHANISM, WHICH I

1567
01:02:24,960 --> 01:02:29,320
FEEL LIKE IN POLICY THIS IS A

1568
01:02:29,320 --> 01:02:30,280
LONG TIME, THAT ONE SUGGESTION

1569
01:02:30,280 --> 01:02:34,040
THAT CAME FROM ME WAS THE IDEA

1570
01:02:34,040 --> 01:02:36,200
OF USING AN R03, PERHAPS EVEN

1571
01:02:36,200 --> 01:02:38,280
R21 MECHANISM, TO TRY TO GET TO

1572
01:02:38,280 --> 01:02:42,680
SOME OF THE ANSWERS FOR HOW

1573
01:02:42,680 --> 01:02:44,040
DIFFERENT HEALTH CARE SETTINGS

1574
01:02:44,040 --> 01:02:47,160
AND HEALTH CARE ISSUES WERE

1575
01:02:47,160 --> 01:02:50,120
AFFECTING DISPARITIES, IN A

1576
01:02:50,120 --> 01:02:52,440
SHORTER TIME FRAME.

1577
01:02:52,440 --> 01:02:53,880
>> OKAY.

1578
01:02:53,880 --> 01:02:54,800
THANK YOU.

1579
01:02:54,800 --> 01:02:57,680
WERE THERE OTHER COMMENTS FROM

1580
01:02:57,680 --> 01:03:05,240
COUNCIL OR PROGRAM ON THIS

1581
01:03:05,240 --> 01:03:06,400
CONCEPT?

1582
01:03:06,400 --> 01:03:10,640
SO, HEARING NONE, ACTUALLY LET 

1583
01:03:10,640 --> 01:03:14,000
ME MAKE SURE THAT I MAKE IT MORE

1584
01:03:14,000 --> 01:03:17,400
CLEAR TO MYSELF, BUT HEARING

1585
01:03:17,400 --> 01:03:23,080
NONE, I WOULD LIKE US TO VOTE ON

1586
01:03:23,080 --> 01:03:24,880
ACCEPTING THIS CONCEPT.

1587
01:03:24,880 --> 01:03:30,080
ALL THOSE IN FAVOR?

1588
01:03:30,080 --> 01:03:31,920
>> AYE.

1589
01:03:31,920 --> 01:03:36,440
>> ANY OPPOSED? 

1590
01:03:36,440 --> 01:03:38,280
IF NOT, THIS CONCEPT IS APPROVED

1591
01:03:38,280 --> 01:03:39,160
BY COUNCIL.

1592
01:03:39,160 --> 01:03:42,760
WE'LL MOVE TO THE NEXT ONE.

1593
01:03:42,760 --> 01:03:44,480
SO, THE NEXT COUNCIL IS

1594
01:03:44,480 --> 01:03:46,800
UNDERSTANDING THE SUPPLY OF

1595
01:03:46,800 --> 01:03:49,040
PROFESSIONAL DEMENTIA CARE

1596
01:03:49,040 --> 01:03:51,840
PROVIDERS AND THEIR DECISIONS.

1597
01:03:51,840 --> 01:03:55,680
THE PRIMARY REVIEWER WAS TERRY

1598
01:03:55,680 --> 01:03:55,880
FULLMER.

1599
01:03:55,880 --> 01:03:57,720
SECONDARY WAS DAVID REUBEN.

1600
01:03:57,720 --> 01:03:59,480
TERRY, IF YOU CAN SUMMARIZE FOR

1601
01:03:59,480 --> 01:04:02,000
US THE DISCUSSION AND YOUR

1602
01:04:02,000 --> 01:04:05,200
RECOMMENDATION FROM YESTERDAY.

1603
01:04:05,200 --> 01:04:07,080
>> HAPPY TO.

1604
01:04:07,080 --> 01:04:10,880
THIS IS AN EXTREMELY IMPORTANT

1605
01:04:10,880 --> 01:04:12,680
AREA OF CONCERN.

1606
01:04:12,680 --> 01:04:14,960
AND THERE WAS ENORMOUS

1607
01:04:14,960 --> 01:04:17,360
ENTHUSIASM ABOUT GETTING AN

1608
01:04:17,360 --> 01:04:19,040
UNDERSTANDING OF THE SUPPLY FOR

1609
01:04:19,040 --> 01:04:20,080
PROFESSIONAL DEMENTIA CARE,

1610
01:04:20,080 --> 01:04:24,920
AMONG AND ACROSS ALL OF US WHO 

1611
01:04:24,920 --> 01:04:27,680
KNOW THAT THE CONFLUENCE OF

1612
01:04:27,680 --> 01:04:29,640
WORKFORCE SHORTAGES IN

1613
01:04:29,640 --> 01:04:31,040
PARTNERSHIP WITH INCREASING

1614
01:04:31,040 --> 01:04:33,080
PERCENTAGES OF PEOPLE WITH

1615
01:04:33,080 --> 01:04:35,080
DEMENTIA MEAN WE HAVE TO

1616
01:04:35,080 --> 01:04:36,040
UNDERSTAND, GET OUR SCIENCE

1617
01:04:36,040 --> 01:04:37,760
STRAIGHT, MOVE IT FORWARD.

1618
01:04:37,760 --> 01:04:43,040
THERE WAS VERY ROBUST ENTHUSIASM

1619
01:04:43,040 --> 01:04:45,680
FOR THIS.

1620
01:04:45,680 --> 01:04:47,160
>> OKAY.

1621
01:04:47,160 --> 01:04:48,640
THANK YOU.

1622
01:04:48,640 --> 01:04:54,200
WERE THERE OTHER COMMENTS FROM

1623
01:04:54,200 --> 01:05:00,240
COUNCIL OR FROM -- FROM COUNCIL

1624
01:05:00,240 --> 01:05:01,280
ON THIS?

1625
01:05:01,280 --> 01:05:05,320
NOT HEARING OR SEEING ANY, I

1626
01:05:05,320 --> 01:05:09,240
WOULD LIKE TO SUGGEST THAT WE

1627
01:05:09,240 --> 01:05:11,440
VOTE ON MOVING THIS, ON

1628
01:05:11,440 --> 01:05:12,520
ACCEPTING THIS.

1629
01:05:12,520 --> 01:05:17,280
ALL THOSE WHO ARE IN FAVOR?

1630
01:05:17,280 --> 01:05:19,240
>> AYE.

1631
01:05:19,240 --> 01:05:22,120
>> AYE. 

1632
01:05:22,120 --> 01:05:23,560
>> AYE.

1633
01:05:23,560 --> 01:05:25,520
>> AYE.

1634
01:05:25,520 --> 01:05:26,280
>> ANY OPPOSITION?

1635
01:05:26,280 --> 01:05:27,920
NO, OKAY.

1636
01:05:27,920 --> 01:05:30,240
NOT HEARING ANY, COUNCIL VOTES

1637
01:05:30,240 --> 01:05:31,520
TO MOVE THIS FORWARD, THIS

1638
01:05:31,520 --> 01:05:32,280
CONCEPT FORWARD.

1639
01:05:32,280 --> 01:05:34,160
WE'LL MOVE TO THE NEXT ONE.

1640
01:05:34,160 --> 01:05:37,760
SO THE NEXT ONE IS ENTITLED,

1641
01:05:37,760 --> 01:05:40,600
MORE MOBILE MONITORING OF

1642
01:05:40,600 --> 01:05:45,400
COGNITIVE CHANGE, CONTINUED, THE

1643
01:05:45,400 --> 01:05:47,600
M 3C 3, SNAPPY TITLE.

1644
01:05:47,600 --> 01:05:50,760
PRIMARY WE VIEWER WAS JENNIFER

1645
01:05:50,760 --> 01:05:53,080
MANLY, SECONDARY WAS DAVID WEIR.

1646
01:05:53,080 --> 01:05:55,320
DR. MANLY, IF YOU WOULD LIKE TO

1647
01:05:55,320 --> 01:06:00,080
SUMMARIZE THE DISCUSSION FROM

1648
01:06:00,080 --> 01:06:00,320
YESTERDAY.

1649
01:06:00,320 --> 01:06:03,520
>> YES, SNAPPY TITLE, VERY

1650
01:06:03,520 --> 01:06:05,400
IMPORTANT RESEARCH THAT WAS

1651
01:06:05,400 --> 01:06:06,800
DESCRIBED IN THIS CONCEPT

1652
01:06:06,800 --> 01:06:07,080
CLEARANCE.

1653
01:06:07,080 --> 01:06:10,280
THERE HAVE BEEN TWO STUDIES THAT

1654
01:06:10,280 --> 01:06:13,680
HAVE BEEN ONGOING FOR THE LAST

1655
01:06:13,680 --> 01:06:15,440
FIVE YEARS THAT ARE DEVELOPING

1656
01:06:15,440 --> 01:06:18,800
MOBILE ASSESSMENT ALSO OF

1657
01:06:18,800 --> 01:06:23,280
COGNITION. 

1658
01:06:23,280 --> 01:06:24,920
THEY ARE DOING THIS BASED ON --

1659
01:06:24,920 --> 01:06:29,920
ONE IS BASED ON THE NIH TOOLBOX,

1660
01:06:29,920 --> 01:06:32,680
A SET OF INSTRUMENTS THAT WERE

1661
01:06:32,680 --> 01:06:34,640
DEVELOPED FOR -- NOW DEVELOPED

1662
01:06:34,640 --> 01:06:37,280
FOR THE IPAD.

1663
01:06:37,280 --> 01:06:41,960
AND THE OTHER IS A MOMENTARY

1664
01:06:41,960 --> 01:06:43,280
COGNITIVE ASSESSMENT.

1665
01:06:43,280 --> 01:06:46,120
AND THE POINT IS THAT EVEN IF

1666
01:06:46,120 --> 01:06:51,040
YOU'RE NOT SITTING ACROSS THE

1667
01:06:51,040 --> 01:06:55,160
DESK FROM A PATIENT OR RESEARCH

1668
01:06:55,160 --> 01:06:57,680
PARTICIPANT, YOU CAN GET A SENSE

1669
01:06:57,680 --> 01:06:59,760
OF THEIR COGNITIVE FUNCTION, NOT

1670
01:06:59,760 --> 01:07:03,280
JUST, YOU KNOW, WHETHER THEY ARE

1671
01:07:03,280 --> 01:07:05,240
HAVING ANY COGNITIVE IMPAIRMENT

1672
01:07:05,240 --> 01:07:07,880
IN DOMAINS LIKE MEMORY,

1673
01:07:07,880 --> 01:07:09,040
EXECUTIVE FUNCTION, LANGUAGE,

1674
01:07:09,040 --> 01:07:10,640
BUT ALSO WHETHER THEIR COGNITION

1675
01:07:10,640 --> 01:07:13,880
HAS CHANGED OVER TIME.

1676
01:07:13,880 --> 01:07:16,560
THIS IS INCREDIBLY IMPORTANT FOR

1677
01:07:16,560 --> 01:07:20,520
SEVERAL GOALS AND MILESTONES OF

1678
01:07:20,520 --> 01:07:23,680
THE NIA IN THEIR AD AND ADRD

1679
01:07:23,680 --> 01:07:24,080
RESEARCH.

1680
01:07:24,080 --> 01:07:25,960
SO THIS CONCEPT CLEARANCE IS TO

1681
01:07:25,960 --> 01:07:29,480
BUILD ON THE WORK THAT'S BEEN

1682
01:07:29,480 --> 01:07:32,000
DONE IN THESE TWO COOPERATIVE

1683
01:07:32,000 --> 01:07:34,400
AGREEMENTS. 

1684
01:07:34,400 --> 01:07:39,280
THEY NOW WANT TO INCLUDE, TO ADD

1685
01:07:39,280 --> 01:07:41,080
NON-COGNITIVE MEASURES,

1686
01:07:41,080 --> 01:07:42,480
BEHAVIORAL ASSESSMENTS, WIDER

1687
01:07:42,480 --> 01:07:44,680
DISSEMINATION OF THE INSTRUMENTS

1688
01:07:44,680 --> 01:07:48,040
TO ALLOW EACH STUDY USING THE

1689
01:07:48,040 --> 01:07:49,480
MEASURES TO CUSTOMIZE THE APPS

1690
01:07:49,480 --> 01:07:53,120
THAT HAVE BEEN DEVELOPED FOR

1691
01:07:53,120 --> 01:07:54,480
THIS WORK TO INCORPORATE

1692
01:07:54,480 --> 01:07:57,040
ELECTRONIC CONSENT FOR MOBILE

1693
01:07:57,040 --> 01:07:58,440
COGNITIVE ASSESSMENT, AND TO

1694
01:07:58,440 --> 01:08:02,680
WORK ON A COST MODEL THAT WILL

1695
01:08:02,680 --> 01:08:06,200
ALLOW FOR REGULAR UPDATES.

1696
01:08:06,200 --> 01:08:10,080
SO, THIS IS A CALL FOR

1697
01:08:10,080 --> 01:08:13,280
APPLICATIONS TO CONTINUE THAT

1698
01:08:13,280 --> 01:08:15,560
WORK, AND THAT THERE WAS A LOT

1699
01:08:15,560 --> 01:08:18,040
OF ENTHUSIASM ABOUT THIS 

1700
01:08:18,040 --> 01:08:21,240
EXCITING WORK IN COUNCIL.

1701
01:08:21,240 --> 01:08:22,280
>> OKAY.

1702
01:08:22,280 --> 01:08:22,800
THANK YOU.

1703
01:08:22,800 --> 01:08:24,520
ARE THERE OTHER COMMENTS OR

1704
01:08:24,520 --> 01:08:30,760
POINTS TO ADD FROM COUNCIL? 

1705
01:08:30,760 --> 01:08:31,520
OKAY.

1706
01:08:31,520 --> 01:08:34,800
HEARING AND SEEING NONE, I'LL

1707
01:08:34,800 --> 01:08:37,680
INVITE THE VOTE ON THIS CONCEPT,

1708
01:08:37,680 --> 01:08:38,520
MOVING FORWARD.

1709
01:08:38,520 --> 01:08:43,120
ALL THOSE IN FAVOR OF THE

1710
01:08:43,120 --> 01:08:43,360
CONCEPT?

1711
01:08:43,360 --> 01:08:44,400
>>  AYE.

1712
01:08:44,400 --> 01:08:46,480
>> AYE.

1713
01:08:46,480 --> 01:08:48,520
>> AYE. 

1714
01:08:48,520 --> 01:08:50,320
>> ANY OPPOSED?

1715
01:08:50,320 --> 01:08:50,880
OKAY.

1716
01:08:50,880 --> 01:08:55,000
THIS CONCEPT MOVES FORWARD AS

1717
01:08:55,000 --> 01:08:59,400
APPROVED BY COUNCIL.

1718
01:08:59,400 --> 01:09:02,040
THE NEXT CONCEPT IS MEASURES AND

1719
01:09:02,040 --> 01:09:04,120
METHODS FOR RESEARCH ON FAMILY

1720
01:09:04,120 --> 01:09:08,080
CAREGIVERS FOR PEOPLE LIVING

1721
01:09:08,080 --> 01:09:09,000
WITH AD/ADRD.

1722
01:09:09,000 --> 01:09:11,800
AND THE PRIMARY REVIEWER ON THIS

1723
01:09:11,800 --> 01:09:13,640
WAS DAVID WEIR, SECONDARY WAS

1724
01:09:13,640 --> 01:09:14,800
JENNIFER MANLY.

1725
01:09:14,800 --> 01:09:18,240
DR. WEIR, IF YOU'D LIKE TO

1726
01:09:18,240 --> 01:09:20,560
SUMMARIZE THE CONCEPT AND

1727
01:09:20,560 --> 01:09:21,760
DISCUSSION FROM YESTERDAY.

1728
01:09:21,760 --> 01:09:24,040
>> SURE. 

1729
01:09:24,040 --> 01:09:27,080
THIS PROPOSAL MET WITH A LOT OF

1730
01:09:27,080 --> 01:09:29,080
ENTHUSIASM, RECOGNIZING THAT

1731
01:09:29,080 --> 01:09:31,000
FAMILY CAREGIVERS FOR PEOPLE

1732
01:09:31,000 --> 01:09:32,560
WITH DEMENTIA PROVIDE PROBABLY

1733
01:09:32,560 --> 01:09:34,600
WELL MORE THAN HALF OF THE TOTAL

1734
01:09:34,600 --> 01:09:38,800
CARE NEEDED BY PEOPLE WITH

1735
01:09:38,800 --> 01:09:39,120
DEMENTIA.

1736
01:09:39,120 --> 01:09:44,040
AND THAT CONCERN HERE IS THAT

1737
01:09:44,040 --> 01:09:45,800
WHILE ESTABLISHED PROJECTS AND

1738
01:09:45,800 --> 01:09:48,000
DBSR DO ASK AND FIND OUT

1739
01:09:48,000 --> 01:09:49,400
INFORMATION ABOUT CAREGIVERS AND

1740
01:09:49,400 --> 01:09:50,160
ABOUT RELATIONSHIP BETWEEN

1741
01:09:50,160 --> 01:09:53,480
CAREGIVERS AND PEOPLE THEY CARE

1742
01:09:53,480 --> 01:09:55,880
FOR, THE WORLD IS CHANGING.

1743
01:09:55,880 --> 01:09:58,040
IN PARTICULAR, MOST OF THOSE

1744
01:09:58,040 --> 01:09:59,280
UNPAID RELATIONSHIPS ARE BASED

1745
01:09:59,280 --> 01:10:01,080
ON A FAMILY CONNECTION AND

1746
01:10:01,080 --> 01:10:04,280
FAMILIES ARE CHANGING, FEWER

1747
01:10:04,280 --> 01:10:05,480
CHILDREN, LESS STABLE MARRIAGES,

1748
01:10:05,480 --> 01:10:06,760
AT LEAST GROWING RECOGNITION IF

1749
01:10:06,760 --> 01:10:08,880
NOT GROWING REALITY OF SEXUAL

1750
01:10:08,880 --> 01:10:11,480
AND GENDER MINORITY KINDS OF

1751
01:10:11,480 --> 01:10:11,840
RELATIONSHIPS.

1752
01:10:11,840 --> 01:10:13,480
SO EVEN AT THE LEVEL OF

1753
01:10:13,480 --> 01:10:14,440
TERMINOLOGY ARE WE ASKING ABOUT

1754
01:10:14,440 --> 01:10:16,280
PEOPLE IN THE RIGHT WAY TO

1755
01:10:16,280 --> 01:10:18,360
CAPTURE THE DIFFERENT KINDS OF

1756
01:10:18,360 --> 01:10:21,080
RELATIONSHIPS THAT MIGHT GIVE

1757
01:10:21,080 --> 01:10:25,240
RISE TO A CARE-GIVING

1758
01:10:25,240 --> 01:10:26,760
RELATIONSHIP.

1759
01:10:26,760 --> 01:10:29,080
SO, THIS WAS TO R21s, I

1760
01:10:29,080 --> 01:10:32,280
THOUGHT WAS A GOOD IDEA AS THEY

1761
01:10:32,280 --> 01:10:35,520
WOULD ENCOURAGE MORE JUNIOR

1762
01:10:35,520 --> 01:10:36,160
INVESTIGATIONS, INVESTIGATIONS

1763
01:10:36,160 --> 01:10:38,920
OF SOME OF THE VULNERABLE

1764
01:10:38,920 --> 01:10:40,480
POPULATIONS, R01s, TO DO MORE

1765
01:10:40,480 --> 01:10:42,240
LARGE SCALE PROJECTS, TO DEVELOP

1766
01:10:42,240 --> 01:10:45,280
NEW MEASURES THAT EXISTING

1767
01:10:45,280 --> 01:10:46,680
STUDIES MIGHT ALSO THEN ADOPT,

1768
01:10:46,680 --> 01:10:51,520
SO WE CAN GET A BETTER PICTURE

1769
01:10:51,520 --> 01:10:53,200
LOOKING AHEAD TO WHETHER MORE

1770
01:10:53,200 --> 01:10:54,160
BROADLY DEFINED NOTION OF FAMILY

1771
01:10:54,160 --> 01:10:56,480
IS GOING TO BE SUFFICIENT TO

1772
01:10:56,480 --> 01:10:58,200
PROVIDE THE CARE THAT THE BABY

1773
01:10:58,200 --> 01:11:00,600
BOOM GENERATION IS GOING TO NEED

1774
01:11:00,600 --> 01:11:04,120
WHEN THEY BEGIN TO DEVELOP 

1775
01:11:04,120 --> 01:11:06,880
DEMENTIA IN LARGE NUMBERS.

1776
01:11:06,880 --> 01:11:07,320
>> OKAY.

1777
01:11:07,320 --> 01:11:09,240
THANK YOU.

1778
01:11:09,240 --> 01:11:11,000
ARE THERE OTHER COMMENTS FROM

1779
01:11:11,000 --> 01:11:17,240
COUNCIL MEMBERS ON THIS CONCEPT?

1780
01:11:17,240 --> 01:11:22,120
NOT HEARING OR SEEING ANY, I

1781
01:11:22,120 --> 01:11:26,720
WOULD INVITE THE COUNCIL TO VOTE

1782
01:11:26,720 --> 01:11:27,840
ON THIS CONCEPT.

1783
01:11:27,840 --> 01:11:31,760
AL 

1784
01:11:31,760 --> 01:11:32,560
ALL THOSE IN FAVOR?

1785
01:11:32,560 --> 01:11:32,960
>>  AYE.

1786
01:11:32,960 --> 01:11:35,480
>> AYE.

1787
01:11:35,480 --> 01:11:35,880
>> YES.

1788
01:11:35,880 --> 01:11:37,800
>> ALL THOSE OPPOSED?

1789
01:11:37,800 --> 01:11:38,440
OKAY.

1790
01:11:38,440 --> 01:11:42,400
SO THIS CONCEPT MOVES AHEAD AS

1791
01:11:42,400 --> 01:11:44,960
APPROVED BY COUNCIL.

1792
01:11:44,960 --> 01:11:47,760
THE NEXT ONE IS BROADENING THE

1793
01:11:47,760 --> 01:12:00,880
SCOPE AND REACH OF NIA'S AD-ADRD

1794
01:12:00,880 --> 01:12:04,960
RESOURCE, THE RCMAR PROGRAM.

1795
01:12:04,960 --> 01:12:07,720
DR. WHITFIELD AND DR. APPLEBY.

1796
01:12:07,720 --> 01:12:09,120
DR. WHITFIELD CAN YOU SUMMARIZE

1797
01:12:09,120 --> 01:12:10,560
THE CONCEPT AND DISCUSSION FROM

1798
01:12:10,560 --> 01:12:11,080
YESTERDAY.

1799
01:12:11,080 --> 01:12:13,680
>> I'M READY FOR THIS ONE.

1800
01:12:13,680 --> 01:12:17,880
THIS ONE IS ON THE RCMAR

1801
01:12:17,880 --> 01:12:18,480
MECHANISM, AND THE RCMAR

1802
01:12:18,480 --> 01:12:21,360
MECHANISM HAS BEEN AROUND SINCE

1803
01:12:21,360 --> 01:12:24,040
I THINK 1997, IN ITS FIFTH ROUND

1804
01:12:24,040 --> 01:12:25,520
MUCH SUPPORT.

1805
01:12:25,520 --> 01:12:38,240
BY ALL METRICS A VERY SUCCESSFUL

1806
01:12:38,240 --> 01:12:39,880
MECHANIC, INCREASING RESEARCH OF

1807
01:12:39,880 --> 01:12:40,320
POPULATIONS.

1808
01:12:40,320 --> 01:12:44,880
THERE'S THREE BASIC PIECES TO

1809
01:12:44,880 --> 01:12:45,320
THIS.

1810
01:12:45,320 --> 01:12:47,080
NOT BASIC, ACTUALLY SOPHISTICATE

1811
01:12:47,080 --> 01:12:49,200
AND SUPPORTIVE ELEMENTS TO THIS.

1812
01:12:49,200 --> 01:12:54,080
THE FIRST ELEMENT IS AN RFA FOR

1813
01:12:54,080 --> 01:12:55,280
P30 APPLICATION REQUEST, AND

1814
01:12:55,280 --> 01:12:56,920
THIS IS FOR CONTINUING RCMAR

1815
01:12:56,920 --> 01:12:59,000
APPLICATIONS THAT FOCUS ON

1816
01:12:59,000 --> 01:13:00,880
BEHAVIORAL AND SOCIAL SCIENCE

1817
01:13:00,880 --> 01:13:02,280
RESEARCH RELATED TO AGING AND/OR

1818
01:13:02,280 --> 01:13:04,880
HEALTH DISPARITIES IN OLDER

1819
01:13:04,880 --> 01:13:05,120
ADULTS.

1820
01:13:05,120 --> 01:13:07,240
THERE'S A P30 APPLICATION PIECE

1821
01:13:07,240 --> 01:13:09,280
FROM INSTITUTION PROPOSING TO

1822
01:13:09,280 --> 01:13:11,680
DEVELOP OR RENEW RCMAR THAT

1823
01:13:11,680 --> 01:13:13,880
FOCUSES ON BEHAVIOR AND SOCIAL

1824
01:13:13,880 --> 01:13:16,680
SCIENCE RESEARCH RELATED TO

1825
01:13:16,680 --> 01:13:18,320
ALZHEIMER'S DISEASE AND RELATED

1826
01:13:18,320 --> 01:13:20,240
DEMENTIA.

1827
01:13:20,240 --> 01:13:23,880
THIRD IS A U24 TO SUPPORT A

1828
01:13:23,880 --> 01:13:25,520
RCMAR COORDINATING CENTER FOR

1829
01:13:25,520 --> 01:13:26,600
P30 AWARDEES.

1830
01:13:26,600 --> 01:13:31,200
ONE NEW ELEMENT THAT IS INCLUDED

1831
01:13:31,200 --> 01:13:33,480
IN THIS REQUEST IS THE IDEA OF

1832
01:13:33,480 --> 01:13:36,120
BEING ABLE TO MAKE BETTER MORE

1833
01:13:36,120 --> 01:13:39,400
EFFECTIVE AND DEEPER

1834
01:13:39,400 --> 01:13:41,920
COLLABORATIONS WITH RESEARCHERS

1835
01:13:41,920 --> 01:13:43,000
FROM HBCUs, HISTORICALLY BLACK

1836
01:13:43,000 --> 01:13:45,080
COLLEGES AND UNIVERSITIES, FROM

1837
01:13:45,080 --> 01:13:47,840
TCUs, TRIBAL COLLEGES AND

1838
01:13:47,840 --> 01:13:51,440
UNIVERSITIES, AND FROM MSI OR

1839
01:13:51,440 --> 01:13:52,280
MINORITY-SERVING INSTITUTION.

1840
01:13:52,280 --> 01:13:55,880
THE SCOPE OF THE RESEARCH

1841
01:13:55,880 --> 01:13:58,520
PROGRAM OVERALL IS ONE OF BEING

1842
01:13:58,520 --> 01:14:01,040
ABLE TO FOSTER ESSENTIAL

1843
01:14:01,040 --> 01:14:02,680
LEADERSHIP SKILLS AND KNOWLEDGE,

1844
01:14:02,680 --> 01:14:04,960
IMPLEMENT TEAM SCIENCE

1845
01:14:04,960 --> 01:14:08,080
STRATEGIES TO PROVIDE FLUBBING

1846
01:14:08,080 --> 01:14:11,600
OF INFRASTRUCTURE TO FOSTER

1847
01:14:11,600 --> 01:14:12,240
MULTI-DISCIPLINARY COLLABORATION

1848
01:14:12,240 --> 01:14:12,720
AND IMPROVE DIVERSITY.

1849
01:14:12,720 --> 01:14:14,520
THAT'S THE MEAT AND POTATOES OF

1850
01:14:14,520 --> 01:14:15,720
THIS RFA.

1851
01:14:15,720 --> 01:14:18,960
I HAD A COUPLE COMMENTS, SOME OF

1852
01:14:18,960 --> 01:14:21,920
THEM WERE ADDRESSED BY PROGRAM.

1853
01:14:21,920 --> 01:14:28,480
ONE WAS THAT WHY WEREN'T HSIs,

1854
01:14:28,480 --> 01:14:29,080
HISPANIC-SERVING INSTITUTIONS

1855
01:14:29,080 --> 01:14:29,880
MENTIONED, SIMPLY AN OVERSIGHT.

1856
01:14:29,880 --> 01:14:31,560
WHO WOULD BE RESPONSIBLE FOR

1857
01:14:31,560 --> 01:14:35,440
CONNECTIONS TO MINORITY

1858
01:14:35,440 --> 01:14:35,760
INSTITUTIONS?

1859
01:14:35,760 --> 01:14:36,960
AND THAT WAS PROVIDED, CLARITY

1860
01:14:36,960 --> 01:14:37,880
WAS PROVIDED BY PROGRAMMING,

1861
01:14:37,880 --> 01:14:40,280
THAT WOULD BE AT THE INDIVIDUAL

1862
01:14:40,280 --> 01:14:42,760
SITE LEVEL.

1863
01:14:42,760 --> 01:14:45,480
ALSO ARE THERE EXPECTATIONS FOR

1864
01:14:45,480 --> 01:14:46,400
LEADERSHIP AND CAREER

1865
01:14:46,400 --> 01:14:47,480
MANAGEMENT, AND, YES, THERE ARE.

1866
01:14:47,480 --> 01:14:52,160
THAT'S GOING TO BE DONE AT THE

1867
01:14:52,160 --> 01:14:54,120
SITE LEVEL.

1868
01:14:54,120 --> 01:14:56,320
ALSO, ONE COMMENT THAT I

1869
01:14:56,320 --> 01:14:57,440
PROVIDED WAS ABOUT WHETHER THERE

1870
01:14:57,440 --> 01:15:00,480
WOULD BE SUPPORT FOR ADDITIONAL

1871
01:15:00,480 --> 01:15:02,560
INTERACTIONS, OTHER THAN JUST

1872
01:15:02,560 --> 01:15:04,720
THE GSA YEARLY MEETINGS WHICH I

1873
01:15:04,720 --> 01:15:07,080
KNOW THE RCMAR TEAM THERE, AND

1874
01:15:07,080 --> 01:15:09,480
THAT WILL BE SOMETHING THAT IS

1875
01:15:09,480 --> 01:15:12,880
TAKEN INTO CONSIDERATION.

1876
01:15:12,880 --> 01:15:14,440
AND LASTLY, I OFFERED THIS PIECE

1877
01:15:14,440 --> 01:15:14,760
OF IT.

1878
01:15:14,760 --> 01:15:16,200
I THINK IT'S ONE WAY WE CAN

1879
01:15:16,200 --> 01:15:20,080
REALLY THINK ABOUT WAYS WE CAN

1880
01:15:20,080 --> 01:15:22,760
MAKE THE KINDS OF INTERACTIONS,

1881
01:15:22,760 --> 01:15:24,640
CONNECTIONS, AND KNOWLEDGE

1882
01:15:24,640 --> 01:15:27,720
SHARED ACROSS THE RCMARs, TO

1883
01:15:27,720 --> 01:15:29,760
CREATE ONLINE CONTENT, PERHAPS

1884
01:15:29,760 --> 01:15:31,280
CREATING MICROCREDENTIALS THAT

1885
01:15:31,280 --> 01:15:35,080
COULD BE SHARED, THE CONTENT

1886
01:15:35,080 --> 01:15:35,560
COULD BE SHARED,

1887
01:15:35,560 --> 01:15:37,080
MICROCREDENTIALS SHARED, RUN BY

1888
01:15:37,080 --> 01:15:38,280
A COORDINATING CENTER.

1889
01:15:38,280 --> 01:15:41,320
THOSE WERE MY COMMENTS AND I

1890
01:15:41,320 --> 01:15:42,680
SUPPORTED THIS CONCEPT.

1891
01:15:42,680 --> 01:15:43,720
>> THANK YOU.

1892
01:15:43,720 --> 01:15:49,200
ARE THERE OTHER COMMENTS OR

1893
01:15:49,200 --> 01:15:50,960
ADDITIONS FROM COUNCIL?

1894
01:15:50,960 --> 01:15:51,640
OKAY.

1895
01:15:51,640 --> 01:15:55,560
SO HEARING OR SEEING NONE, SOUND

1896
01:15:55,560 --> 01:15:56,880
LIKE THERE'S CONSIDERABLE

1897
01:15:56,880 --> 01:15:58,600
ENTHUSIASM FOR MOVING THIS

1898
01:15:58,600 --> 01:15:59,760
CONCEPT FORWARD.

1899
01:15:59,760 --> 01:16:05,680
I'D LIKE TO ASK FOR A VOTE ON

1900
01:16:05,680 --> 01:16:06,640
APPROVAL.

1901
01:16:06,640 --> 01:16:07,000
>> SO MOVED.

1902
01:16:07,000 --> 01:16:09,480
>> ALL THOSE IN FAVOR?

1903
01:16:09,480 --> 01:16:11,640
>> AYE.

1904
01:16:11,640 --> 01:16:12,000
>> AYE.

1905
01:16:12,000 --> 01:16:13,240
>> ALL THOSE OPPOSED?

1906
01:16:13,240 --> 01:16:13,680
GREAT.

1907
01:16:13,680 --> 01:16:16,280
IF NOT, WE WILL MOVE TO THE LAST

1908
01:16:16,280 --> 01:16:19,400
APPLICATION FROM THE DIVISION OF

1909
01:16:19,400 --> 01:16:21,000
BEHAVIORAL AND SOCIAL RESEARCH.

1910
01:16:21,000 --> 01:16:23,200
THE TITLE OF THIS CONCEPT IS

1911
01:16:23,200 --> 01:16:25,920
PREDICTING EARLY ALZHEIMER'S

1912
01:16:25,920 --> 01:16:28,440
DISEASE AND RELATED DEMENTIA IN

1913
01:16:28,440 --> 01:16:30,280
DIVERSE POPULATIONS.

1914
01:16:30,280 --> 01:16:32,680
THE PRIMARY REVIEWER IS ERIC

1915
01:16:32,680 --> 01:16:35,320
REIMANN, SECOND WAS JENNIFER

1916
01:16:35,320 --> 01:16:35,640
MANLY.

1917
01:16:35,640 --> 01:16:38,480
DR. REIMANN, IF YOU WILL START

1918
01:16:38,480 --> 01:16:40,880
BY SUMMARIZING THE NATURE OF

1919
01:16:40,880 --> 01:16:44,200
THIS CONCEPT AND THE DISCUSSION.

1920
01:16:44,200 --> 01:16:44,960
>> THANK YOU, MONICA.

1921
01:16:44,960 --> 01:16:47,480
I'LL TAKE A LITTLE BIT MORE TIME

1922
01:16:47,480 --> 01:16:50,360
THAN USUAL TO SUMMARIZE THE

1923
01:16:50,360 --> 01:16:52,160
CONCEPT, AND THE DISCUSSION.

1924
01:16:52,160 --> 01:16:55,840
THIS CONCEPT IS A GRAND

1925
01:16:55,840 --> 01:16:57,720
CHALLENGE THAT WOULD CAPITALIZE

1926
01:16:57,720 --> 01:16:58,640
ON THE PRIZE COMPETITION

1927
01:16:58,640 --> 01:16:59,840
MECHANISM IN THE AMERICA

1928
01:16:59,840 --> 01:17:03,680
COMPETES ACT TO FIND BETTER WAYS

1929
01:17:03,680 --> 01:17:05,960
TO DETECT SUBTLE CHANGES

1930
01:17:05,960 --> 01:17:07,560
ASSOCIATED WITH PRE-CLINICAL

1931
01:17:07,560 --> 01:17:09,200
ALZHEIMER'S DISEASE AND RELATED

1932
01:17:09,200 --> 01:17:12,800
DEMENTIA IN DIVERSE POPULATIONS.

1933
01:17:12,800 --> 01:17:16,480
THE COMPETITION WOULD PROVIDE

1934
01:17:16,480 --> 01:17:17,360
THREE SEQUENTIAL CHALLENGES THAT

1935
01:17:17,360 --> 01:17:20,680
WOULD HAVE THE GOALS OF

1936
01:17:20,680 --> 01:17:22,000
PROVIDING COGNITIVE CLINICAL EHR

1937
01:17:22,000 --> 01:17:23,480
CLAIMS, BIOMARKERS, AND OTHER

1938
01:17:23,480 --> 01:17:26,320
KINDS OF DATA FROM DIVERSE

1939
01:17:26,320 --> 01:17:28,520
POPULATIONS, TO HELP UNDERSTAND

1940
01:17:28,520 --> 01:17:30,280
AND ADDRESS POTENTIAL BIASES,

1941
01:17:30,280 --> 01:17:33,680
MAKE THOSE DATA WIDELY AVAILABLE

1942
01:17:33,680 --> 01:17:35,720
THROUGH TRUSTED REPOSITORIES,

1943
01:17:35,720 --> 01:17:37,480
ESTABLISH ABILITY OF ARTIFICIAL

1944
01:17:37,480 --> 01:17:39,080
INTELLIGENCE MACHINE LEARNING

1945
01:17:39,080 --> 01:17:41,080
AND OTHER PREDICTIVE ALGORITHMS

1946
01:17:41,080 --> 01:17:44,320
TO CHARACTERIZE THE EARLIEST

1947
01:17:44,320 --> 01:17:47,320
MANIFESTATIONS OF ALZHEIMER'S

1948
01:17:47,320 --> 01:17:48,440
DISEASE, EXPLAIN TO STAKEHOLDERS

1949
01:17:48,440 --> 01:17:50,600
HOW ALGORITHMS REACH THEIR

1950
01:17:50,600 --> 01:17:53,880
CONCLUSIONS, AND DEMONSTRATE

1951
01:17:53,880 --> 01:17:55,200
THEIR ABILITY TO CHARACTERIZE

1952
01:17:55,200 --> 01:18:01,520
INDIVIDUALS FREE FROM RACIAL, 

1953
01:18:01,520 --> 01:18:03,280
ETHNIC SOURCE OR ALGORITHMIC

1954
01:18:03,280 --> 01:18:03,640
BIASES.

1955
01:18:03,640 --> 01:18:06,120
THE GRAND CHALLENGE WAS

1956
01:18:06,120 --> 01:18:10,040
DEVELOPED IN RESPONSE TO NACA

1957
01:18:10,040 --> 01:18:13,000
MILESTONE 14-POINTC, RELATED

1958
01:18:13,000 --> 01:18:14,840
RECOMMENDATION ALSO FROM THE

1959
01:18:14,840 --> 01:18:16,040
2019 DIVISION OF NEUROSCIENCE

1960
01:18:16,040 --> 01:18:19,200
REVIEW COMMITTEE, WHICH SEEKS TO

1961
01:18:19,200 --> 01:18:22,280
CAPITALIZE ON NOVEL DISRUPTIVE

1962
01:18:22,280 --> 01:18:24,120
SCIENCE THAT WOULD INCENTIVIZE

1963
01:18:24,120 --> 01:18:25,680
INDIVIDUALS TO ADOPT

1964
01:18:25,680 --> 01:18:27,480
COLLABORATIVE AROACH TO RESEARCH

1965
01:18:27,480 --> 01:18:30,880
THROUGH USE OF TARGETED SMALL

1966
01:18:30,880 --> 01:18:32,920
FUNDING SCHEMES.

1967
01:18:32,920 --> 01:18:34,800
COUNCIL MEMBERS EXPRESSED

1968
01:18:34,800 --> 01:18:35,920
SUPPORT FOR THIS EXCITING

1969
01:18:35,920 --> 01:18:39,840
CONCEPT, BUT NOTED THE

1970
01:18:39,840 --> 01:18:40,720
DEVELOPMENT OF PREDICTIVE

1971
01:18:40,720 --> 01:18:43,120
ALGORITHMS FOR DETECTION OF

1972
01:18:43,120 --> 01:18:44,040
PRE-CLINICAL ALZHEIMER'S DISEASE

1973
01:18:44,040 --> 01:18:45,480
DEPEND ON SUFFICIENT AMOUNT OF

1974
01:18:45,480 --> 01:18:48,280
BIOMARKER DATA TO RELATE THESE

1975
01:18:48,280 --> 01:18:51,240
ALGORITHMS TOP DIAGNOSIS OF

1976
01:18:51,240 --> 01:18:52,320
PRE-CLINICAL ALZHEIMER'S

1977
01:18:52,320 --> 01:18:56,920
DISEASE, AND/OR TO PREDICT --

1978
01:18:56,920 --> 01:18:59,680
DATA TO PREDICT SUBSEQUENT

1979
01:18:59,680 --> 01:19:01,320
PROGRESSION TO CLINICAL STAGES

1980
01:19:01,320 --> 01:19:01,960
OF DISEASE INDEPENDENT MUCH

1981
01:19:01,960 --> 01:19:04,680
KNOWING WHO DOES OR DOES NOT

1982
01:19:04,680 --> 01:19:06,520
HAVE PRE-CLINICAL ALZHEIMER'S

1983
01:19:06,520 --> 01:19:07,480
DISEASE.

1984
01:19:07,480 --> 01:19:09,120
IN DIVERSE POPULATIONS,

1985
01:19:09,120 --> 01:19:09,680
INCLUDING HAVING SUFFICIENT

1986
01:19:09,680 --> 01:19:12,440
AMOUNT OF DATA FROM

1987
01:19:12,440 --> 01:19:13,280
UNDERREPRESENTED GROUPS.

1988
01:19:13,280 --> 01:19:15,760
WHILE THERE MAY BE SUFFICIENT

1989
01:19:15,760 --> 01:19:17,680
DATA TO ENABLE PREDICTIVE

1990
01:19:17,680 --> 01:19:20,640
ALGORITHMS TO INFORM COGNITIVELY

1991
01:19:20,640 --> 01:19:21,680
UNIMPAIRED PERSONS PROGNOSIS,

1992
01:19:21,680 --> 01:19:23,840
WITHOUT KNOWING WHETHER OR NOT

1993
01:19:23,840 --> 01:19:25,200
THEY HAD PRE-CLINICAL

1994
01:19:25,200 --> 01:19:27,480
ALZHEIMER'S DISEASE, THERE MAY

1995
01:19:27,480 --> 01:19:29,880
NOT BE SUFFICIENT BIOMARKER DATA

1996
01:19:29,880 --> 01:19:32,960
JUST YET IN UNDERREPRESENTED

1997
01:19:32,960 --> 01:19:33,200
GROUPS.

1998
01:19:33,200 --> 01:19:35,800
AND INSUFFICIENT NUMBERS OF

1999
01:19:35,800 --> 01:19:36,880
PERSONS FROM UNDERREPRESENTED

2000
01:19:36,880 --> 01:19:41,160
GROUPS HAVE PET OR CSF 

2001
01:19:41,160 --> 01:19:43,320
BIOMARKERS TO CONFIRM

2002
01:19:43,320 --> 01:19:43,920
PRE-CLINICAL ALZHEIMER'S

2003
01:19:43,920 --> 01:19:46,440
DISEASE, USING THESE STANDARDS

2004
01:19:46,440 --> 01:19:48,680
OF TRUTH.

2005
01:19:48,680 --> 01:19:49,920
EMERGING BLOOD-BASED BIOMARKERS

2006
01:19:49,920 --> 01:19:52,080
ONCE VALIDATED AND SHOWN TO BE

2007
01:19:52,080 --> 01:19:52,520
GENERALIZABLE TO

2008
01:19:52,520 --> 01:19:53,360
UNDERREPRESENTED GROUPS WHICH

2009
01:19:53,360 --> 01:19:58,120
MAY HAPPEN IN THE NEXT  ONE TO

2010
01:19:58,120 --> 01:20:04,240
TWO YEARS, IF SHOWN TO BE 

2011
01:20:04,240 --> 01:20:06,200
ROBUST COULD ADDRESS THIS ISSUE.

2012
01:20:06,200 --> 01:20:07,440
THERE SHOULD BE EFFORT

2013
01:20:07,440 --> 01:20:09,080
INDEPENDENT OF CONCEPT TO ENSURE

2014
01:20:09,080 --> 01:20:11,680
BLOOD SAMPLES ARE AVAILABLE AND

2015
01:20:11,680 --> 01:20:13,120
THEN SUITABLE BLOOD-BASED

2016
01:20:13,120 --> 01:20:14,640
BIOMARKERS DEPLOYED FIRST IN A

2017
01:20:14,640 --> 01:20:17,280
SCALABLE WAY, SUCH THAT THE

2018
01:20:17,280 --> 01:20:18,280
CONCEPT COULD PROCEED LATER,

2019
01:20:18,280 --> 01:20:20,120
HOPEFULLY IN THE NEXT TWO YEARS,

2020
01:20:20,120 --> 01:20:23,600
AND HAVE A GREATER CHANCE OF

2021
01:20:23,600 --> 01:20:25,280
SUCCESS.

2022
01:20:25,280 --> 01:20:26,680
>> THANK YOU VERY MUCH.

2023
01:20:26,680 --> 01:20:29,080
SO, YES, THIS WAS A CONCEPT

2024
01:20:29,080 --> 01:20:31,920
WHERE THERE WAS CONSIDERABLE

2025
01:20:31,920 --> 01:20:32,880
DISCUSSION.

2026
01:20:32,880 --> 01:20:36,040
DID OTHER MEMBERS OF THE COUNCIL

2027
01:20:36,040 --> 01:20:38,480
WANT TO COMMENT ON THIS?

2028
01:20:38,480 --> 01:20:43,440
I'M SORRY, I HAVE TO CHANGE MY

2029
01:20:43,440 --> 01:20:43,640
VIEW.

2030
01:20:43,640 --> 01:20:45,840
>> MY ONLY COMMENT, DR.

2031
01:20:45,840 --> 01:20:49,200
DRISCOLL, I THINK THERE WAS A

2032
01:20:49,200 --> 01:20:51,280
LOT OF ENTHUSIASM ABOUT THE

2033
01:20:51,280 --> 01:20:57,640
CHALLENGE IDEA, IN THE PAST

2034
01:20:57,640 --> 01:21:01,480
THESE CHALLENGES HAVE REALLY

2035
01:21:01,480 --> 01:21:03,960
PROVIDED A WAY FOR TEAMS THAT

2036
01:21:03,960 --> 01:21:05,920
WOULDN'T NORMALLY GET INVOLVED

2037
01:21:05,920 --> 01:21:10,040
IN ALZHEIMER'S DISEASE RESEARCH

2038
01:21:10,040 --> 01:21:14,280
TO ENGAGE, AND THAT THE TEAMS

2039
01:21:14,280 --> 01:21:15,280
WOULD BE MULTI-DISCIPLINARY.

2040
01:21:15,280 --> 01:21:17,080
I DO WANT TO DOUBLE DOWN ON

2041
01:21:17,080 --> 01:21:19,560
SOMETHING THAT YOU SAID, WHICH

2042
01:21:19,560 --> 01:21:23,280
IS THAT RIGHT NOW A LOT OF THE

2043
01:21:23,280 --> 01:21:26,760
MULTI-LEVEL DATA THAT WOULD BE

2044
01:21:26,760 --> 01:21:29,640
NEEDED TO DEVELOP A REALLY

2045
01:21:29,640 --> 01:21:31,360
STRONG PREDICTIVE MODEL MAY NOT

2046
01:21:31,360 --> 01:21:35,880
BE THERE, ESPECIALLY FOR GROUPS

2047
01:21:35,880 --> 01:21:39,000
THAT EXPERIENCE HIGHER RISK OF

2048
01:21:39,000 --> 01:21:41,240
DEVELOPING ALZHEIMER'S DISEASE

2049
01:21:41,240 --> 01:21:41,560
AND DEMENTIA.

2050
01:21:41,560 --> 01:21:46,680
AND SO, YOU KNOW, WE LOOK

2051
01:21:46,680 --> 01:21:50,360
FORWARD TO THE CONCEPT 

2052
01:21:50,360 --> 01:21:51,920
CLEARANCE, YOU KNOW, BEING VERY

2053
01:21:51,920 --> 01:21:54,720
CLEAR ABOUT WHERE THESE DATA

2054
01:21:54,720 --> 01:21:58,400
WOULD COME FROM AND AT WHAT

2055
01:21:58,400 --> 01:22:03,400
POINT THE WORK CAN ADVANCE, IF

2056
01:22:03,400 --> 01:22:07,440
THERE ISN'T THE AMOUNT OF DATA

2057
01:22:07,440 --> 01:22:09,840
OR THE SOPHISTICATION OF DATA

2058
01:22:09,840 --> 01:22:12,200
THAT IS NECESSARY TO DEVELOP

2059
01:22:12,200 --> 01:22:14,680
THESE MODELS.

2060
01:22:14,680 --> 01:22:15,400
 

2061
01:22:15,400 --> 01:22:18,000
>> THANK YOU.

2062
01:22:18,000 --> 01:22:24,280
ARE THERE OTHER COMMENTS?

2063
01:22:24,280 --> 01:22:25,520
OH, MERRYL PLEASE.

2064
01:22:25,520 --> 01:22:27,480
>> I WOULD LIKE TO SAY WITH THE

2065
01:22:27,480 --> 01:22:29,200
CHALLENGE AND OPPORTUNITY TO

2066
01:22:29,200 --> 01:22:30,200
HAVE CROSS-FUNCTIONAL TEAMS,

2067
01:22:30,200 --> 01:22:32,160
WHAT THE STUDIES HAVE SHOWN IS

2068
01:22:32,160 --> 01:22:37,200
THAT IT ALSO LEVELS THE PLAYING 

2069
01:22:37,200 --> 01:22:38,600
FIELD FOR WOMEN RESEARCHERS.

2070
01:22:38,600 --> 01:22:40,480
SO I THINK THAT DYNAMIC SHOULD

2071
01:22:40,480 --> 01:22:44,040
BE RECOGNIZED FOR THE YOUNGER

2072
01:22:44,040 --> 01:22:46,080
INVESTIGATORS.

2073
01:22:46,080 --> 01:22:46,480
>> THANK YOU.

2074
01:22:46,480 --> 01:22:48,920
OTHER COMMENTS?

2075
01:22:48,920 --> 01:22:55,360
I THINK, YOU KNOW, IN THIS CASE

2076
01:22:55,360 --> 01:22:57,800
IT SOUNDS LIKE, AGAIN, AS DR.

2077
01:22:57,800 --> 01:22:59,240
MANLY WAS SAYING, THERE'S A LOT 

2078
01:22:59,240 --> 01:23:02,640
OF ENTHUSIASM FOR THE CHALLENGE 

2079
01:23:02,640 --> 01:23:04,760
IDEA AND THE STRUCTURING OF THE 

2080
01:23:04,760 --> 01:23:06,680
APPROACH, BUT THERE'S SOME

2081
01:23:06,680 --> 01:23:11,600
CONCERNS ABOUT WHETHER IT'S THE

2082
01:23:11,600 --> 01:23:12,680
STARTING MATERIALS ARE THERE TO

2083
01:23:12,680 --> 01:23:15,680
ACTUALLY MOVE FORWARD.

2084
01:23:15,680 --> 01:23:21,600
AND SO I'M WONDERING IF THE TWO

2085
01:23:21,600 --> 01:23:22,840
REVIEWERS WANT TO SPECIFICALLY

2086
01:23:22,840 --> 01:23:26,840
STATE WHAT THE MOTION IS THAT

2087
01:23:26,840 --> 01:23:30,880
WE -- OR WHAT COUNCIL'S VOTE ON

2088
01:23:30,880 --> 01:23:33,000
THIS IS -- WHAT YOU'RE OF YOUR

2089
01:23:33,000 --> 01:23:35,600
PERCEPTION OF THAT IS. 

2090
01:23:35,600 --> 01:23:39,840
>> I WOULD LIKE TO COMMEND NIA

2091
01:23:39,840 --> 01:23:43,680
FOR BRINGING THIS CHALLENGE

2092
01:23:43,680 --> 01:23:45,640
FORWARD.

2093
01:23:45,640 --> 01:23:48,040
I WOULD LIKE TO POSTPONE THE

2094
01:23:48,040 --> 01:23:50,920
DECISION TO A FUTURE TIME TO

2095
01:23:50,920 --> 01:23:51,640
CONSIDER THE CHALLENGE ONCE SOME

2096
01:23:51,640 --> 01:23:54,840
OF THE OTHER ISSUES ARE

2097
01:23:54,840 --> 01:23:56,960
ADDRESSED, AND HOPE THAT WE

2098
01:23:56,960 --> 01:23:59,000
WOULD BE ABLE TO SEE THE --

2099
01:23:59,000 --> 01:24:00,040
REVISIT THE CHALLENGE WITHIN THE

2100
01:24:00,040 --> 01:24:01,600
NEXT TWO YEARS.

2101
01:24:01,600 --> 01:24:05,640
SO I'D LIKE TO PROPOSE THAT

2102
01:24:05,640 --> 01:24:07,120
WE -- THAT CONTINUED ACTION

2103
01:24:07,120 --> 01:24:09,440
HAPPEN THAT WE ULTIMATELY SEE

2104
01:24:09,440 --> 01:24:11,200
THIS BUT THAT WE POSTPONE 

2105
01:24:11,200 --> 01:24:14,480
APPROVAL AT THIS TIME.

2106
01:24:14,480 --> 01:24:15,360
>> I AGREE.

2107
01:24:15,360 --> 01:24:19,920
AND I ESPECIALLY AGREE WITH THE

2108
01:24:19,920 --> 01:24:23,120
COMMENDING OF THE -- OF NIA

2109
01:24:23,120 --> 01:24:28,760
PROGRAM FOR INNOVATING THIS

2110
01:24:28,760 --> 01:24:31,480
IDEA, ALWAYS THINKING ABOUT

2111
01:24:31,480 --> 01:24:33,880
INNOVATION, AND THE SPIRIT

2112
01:24:33,880 --> 01:24:37,400
BEHIND THIS IS ABSOLUTELY ON

2113
01:24:37,400 --> 01:24:37,760
POINT.

2114
01:24:37,760 --> 01:24:44,080
AND LOOK FORWARD TO WORKING ON

2115
01:24:44,080 --> 01:24:44,960
THE DETAILS.

2116
01:24:44,960 --> 01:24:49,000
>> THE MOTION OTHER VOTE ON THIS

2117
01:24:49,000 --> 01:24:50,080
PARTICULAR CONCEPT IS TO

2118
01:24:50,080 --> 01:24:54,600
POSTPONE, I DON'T KNOW, KEN, IF

2119
01:24:54,600 --> 01:24:56,000
THAT'S THE CORRECT TERMINOLOGY,

2120
01:24:56,000 --> 01:24:57,960
BUT THAT WOULD BE THE

2121
01:24:57,960 --> 01:24:58,760
RECOMMENDATION.

2122
01:24:58,760 --> 01:25:00,560
>> I THINK DEFER IS PROBABLY

2123
01:25:00,560 --> 01:25:00,840
CORRECT.

2124
01:25:00,840 --> 01:25:03,200
>> DEFER, OKAY.

2125
01:25:03,200 --> 01:25:06,400
SO THE VOTE IS WHETHER THE

2126
01:25:06,400 --> 01:25:09,400
COUNCIL APPROVES TO DEFER THIS

2127
01:25:09,400 --> 01:25:10,640
PARTICULAR CONCEPT.

2128
01:25:10,640 --> 01:25:12,880
>> ONE COMMENT.

2129
01:25:12,880 --> 01:25:13,440
>> PLEASE.

2130
01:25:13,440 --> 01:25:14,520
>> THANK YOU.

2131
01:25:14,520 --> 01:25:19,080
THEY COULD POSTPONE, I AGREE

2132
01:25:19,080 --> 01:25:19,400
WITH THAT.

2133
01:25:19,400 --> 01:25:21,280
>> JULIE, I'M HAVING A TINY BIT

2134
01:25:21,280 --> 01:25:24,520
OF TROUBLE HEARING YOU CLEARLY.

2135
01:25:24,520 --> 01:25:25,280
>> OH.

2136
01:25:25,280 --> 01:25:25,920
CAN YOU HEAR ME NOW?

2137
01:25:25,920 --> 01:25:28,520
>>  MUCH BETTER, THANK YOU.

2138
01:25:28,520 --> 01:25:28,800
>> OKAY.

2139
01:25:28,800 --> 01:25:30,720
SO, I AGREE WITH THE WAY IT'S

2140
01:25:30,720 --> 01:25:33,480
CURRENTLY WRITTEN THAT IT WOULD

2141
01:25:33,480 --> 01:25:39,480
NEED TO BE POSTPONED, BUT COULD

2142
01:25:39,480 --> 01:25:43,280
ALSO CONSIDER RESTRUCTURING THE

2143
01:25:43,280 --> 01:25:48,080
PROPOSAL INTO -- RATHER THAN

2144
01:25:48,080 --> 01:25:50,720
NECESSARILY PRE-CLINICAL, INTO

2145
01:25:50,720 --> 01:25:53,080
VERY MILD CLINICAL DISEASE OR,

2146
01:25:53,080 --> 01:25:54,800
YOU KNOW, RISK FACTORS.

2147
01:25:54,800 --> 01:25:58,160
I DO THINK THERE COULD BE SPACE

2148
01:25:58,160 --> 01:26:01,240
FOR THIS, IF THEY MOVE OUT OF

2149
01:26:01,240 --> 01:26:02,440
THE PRE-CLINICAL SPACE.

2150
01:26:02,440 --> 01:26:05,480
THERE WOULD BE SPACE SOONER FOR

2151
01:26:05,480 --> 01:26:08,960
DOING SOME OF THESE

2152
01:26:08,960 --> 01:26:09,960
INVESTIGATIONS.

2153
01:26:09,960 --> 01:26:10,560
>> OKAY.

2154
01:26:10,560 --> 01:26:11,040
THANK YOU.

2155
01:26:11,040 --> 01:26:13,080
I THINK -- SO, AGAIN, KEN CAN

2156
01:26:13,080 --> 01:26:14,280
COMMENT ON THE OFFICIAL THINGS

2157
01:26:14,280 --> 01:26:16,880
WE CAN AND CAN'T DO.

2158
01:26:16,880 --> 01:26:19,840
I THINK WE'RE PRETTY MUCH BOUND

2159
01:26:19,840 --> 01:26:24,880
TO VOTE ON THE CONCEPT OR THE

2160
01:26:24,880 --> 01:26:26,440
CONCEPT CONSEQUENT TO DISCUSSION

2161
01:26:26,440 --> 01:26:27,880
WITH PROGRAM.

2162
01:26:27,880 --> 01:26:31,040
SO, YEAH, IS THAT CORRECT, KEN?

2163
01:26:31,040 --> 01:26:31,680
>>  YES.

2164
01:26:31,680 --> 01:26:34,960
I'VE TAKEN NOTE OF ALL THE

2165
01:26:34,960 --> 01:26:36,240
COMMENTS AND CONSIDERATIONS.

2166
01:26:36,240 --> 01:26:37,920
WE'LL BRING THAT BACK TO

2167
01:26:37,920 --> 01:26:38,160
PROGRAM.

2168
01:26:38,160 --> 01:26:42,840
AND THEN WE CAN CIRCLE BACK WITH

2169
01:26:42,840 --> 01:26:46,280
THE COUNCIL MEMBERS AT A FUTURE

2170
01:26:46,280 --> 01:26:46,480
TIME.

2171
01:26:46,480 --> 01:26:47,280
>> THANK YOU.

2172
01:26:47,280 --> 01:26:49,680
ARE THERE OTHER COMMENTS ON

2173
01:26:49,680 --> 01:26:50,880
THIS? 

2174
01:26:50,880 --> 01:26:53,640
HEARING AND SEEING NONE, I WOULD

2175
01:26:53,640 --> 01:26:58,520
LIKE TO JUST SUMMARIZE THAT

2176
01:26:58,520 --> 01:27:01,800
WE'RE ABOUT TO VOTE ON WHETHER

2177
01:27:01,800 --> 01:27:04,000
TO DEFER THIS PARTICULAR

2178
01:27:04,000 --> 01:27:04,240
CONCEPT.

2179
01:27:04,240 --> 01:27:07,840
SO, ALL THOSE IN FAVOR OF A

2180
01:27:07,840 --> 01:27:08,080
DEFERRAL?

2181
01:27:08,080 --> 01:27:08,800
>>  AYE.

2182
01:27:08,800 --> 01:27:09,440
>> AYE.

2183
01:27:09,440 --> 01:27:10,600
>> AYE.

2184
01:27:10,600 --> 01:27:12,080
>> AYE.

2185
01:27:12,080 --> 01:27:13,280
>> AYE.

2186
01:27:13,280 --> 01:27:15,800
>> ANY OPPOSED? 

2187
01:27:15,800 --> 01:27:16,000
OKAY.

2188
01:27:16,000 --> 01:27:20,080
NOT HEARING ANY, WE ARE MOVING

2189
01:27:20,080 --> 01:27:23,200
TO THE NEXT SET OF CONCEPTS, WE

2190
01:27:23,200 --> 01:27:28,640
HAVE ONE FROM DIVISION OF 

2191
01:27:28,640 --> 01:27:29,560
GERIATRICS AND CLINICAL

2192
01:27:29,560 --> 01:27:31,200
GERONTOLOGY.

2193
01:27:31,200 --> 01:27:32,760
LET ME JUST PULL UP -- YEAH,

2194
01:27:32,760 --> 01:27:34,480
THERE WE GO.

2195
01:27:34,480 --> 01:27:36,920
THE TITLE IS OPTIMIZATION AND

2196
01:27:36,920 --> 01:27:38,680
PERSONALIZATION OF DIAGNOSTIC

2197
01:27:38,680 --> 01:27:42,680
TESTS FOR AD/ADRD IN OLDER

2198
01:27:42,680 --> 01:27:44,560
ADULTS WITH MULTIPLE CHRONIC

2199
01:27:44,560 --> 01:27:47,400
CONDITIONS, THE PRIMARY REVIEWER

2200
01:27:47,400 --> 01:27:49,360
WAS DAVID REUBEN, SECOND WAS

2201
01:27:49,360 --> 01:27:50,600
JENNIFER MANLY.

2202
01:27:50,600 --> 01:27:52,440
DR. RUBEN, IF YOU CAN SUMMARIZE

2203
01:27:52,440 --> 01:27:55,200
THE CONCEPT AND THE DISCUSSION

2204
01:27:55,200 --> 01:27:56,280
FROM YESTERDAY.

2205
01:27:56,280 --> 01:27:56,600
THANKS.

2206
01:27:56,600 --> 01:27:59,080
>> THANK YOU.

2207
01:27:59,080 --> 01:28:03,240
IT'S VERY TIMELY SINCE THIS IS A

2208
01:28:03,240 --> 01:28:06,520
CONCEPT CLEARANCE THAT WAS

2209
01:28:06,520 --> 01:28:08,000
DEFERRED LAST TIME.

2210
01:28:08,000 --> 01:28:11,480
AND THE NIA PROGRAM STAFF HAVE

2211
01:28:11,480 --> 01:28:14,480
WORKED ON IT, AND BOTH MYSELF

2212
01:28:14,480 --> 01:28:15,680
AND SPEAKING FOR JENNIFER, BOTH

2213
01:28:15,680 --> 01:28:19,040
FELT IT WAS CONSIDERABLY

2214
01:28:19,040 --> 01:28:20,800
APPROVED BY ITERATIVE PROCESS OF

2215
01:28:20,800 --> 01:28:23,480
GETTING FEEDBACK FROM COUNCIL

2216
01:28:23,480 --> 01:28:26,360
AND THEN REDOING IT.

2217
01:28:26,360 --> 01:28:29,760
IN THE NEW CONCEPT, THE FOCUS IS

2218
01:28:29,760 --> 01:28:32,760
NARROWED TO DIAGNOSTIC TESTING,

2219
01:28:32,760 --> 01:28:35,880
IN MCC, AND ALTHOUGH DIAGNOSTIC

2220
01:28:35,880 --> 01:28:39,040
TESTING HAS NOT BEEN AS HELPFUL

2221
01:28:39,040 --> 01:28:41,720
AS WE WOULD HOPE, IN THE CURRENT

2222
01:28:41,720 --> 01:28:45,520
MANAGEMENT OF ALZHEIMER'S AND

2223
01:28:45,520 --> 01:28:55,480
RELATED DEMENTIAS, AS  NEW 

2224
01:28:55,480 --> 01:28:58,280
THERAPEUTICS (INAUDIBLE) THIS

2225
01:28:58,280 --> 01:29:00,080
MAY BE INCREASINGLY IMPORTANT,

2226
01:29:00,080 --> 01:29:01,640
PARTICULARLY IF THOSE

2227
01:29:01,640 --> 01:29:07,080
THERAPEUTICS TURN OUT TO BE

2228
01:29:07,080 --> 01:29:07,480
EFFECTIVE.

2229
01:29:07,480 --> 01:29:12,800
IT ALSO MAY HELP CLARIFY THE

2230
01:29:12,800 --> 01:29:14,920
ROLE OF THE ALZHEIMER'S DISEASE

2231
01:29:14,920 --> 01:29:20,960
VERSUS THE ROLE OF MCCs IN

2232
01:29:20,960 --> 01:29:22,400
DETERMINING THE FUNCTIONAL AND

2233
01:29:22,400 --> 01:29:25,280
OTHER IMPAIRMENTS THAT ARE

2234
01:29:25,280 --> 01:29:26,320
ASSOCIATED WITH DEMENTIA.

2235
01:29:26,320 --> 01:29:28,440
FINALLY, THE OTHER THING THAT WE

2236
01:29:28,440 --> 01:29:33,520
THOUGHT WAS REALLY VALUABLE IS

2237
01:29:33,520 --> 01:29:35,680
THIS WOULD PROVIDE TREMENDOUS

2238
01:29:35,680 --> 01:29:38,160
INFORMATION ABOUT HELPING CMS IN

2239
01:29:38,160 --> 01:29:45,080
POLICY DECISIONS REGARDING 

2240
01:29:45,080 --> 01:29:47,400
COVERAGE OF DIAGNOSTIC TESTING.

2241
01:29:47,400 --> 01:29:54,120
RIGHT NOW COVERAGE IS  EXTREMELY

2242
01:29:54,120 --> 01:29:56,200
LIMIT OF LIMITED FOR LARGE

2243
01:29:56,200 --> 01:29:57,840
SEGMENTS OF THE POPULATION, WE

2244
01:29:57,840 --> 01:29:59,480
THOUGHT THAT WAS VALUABLE.

2245
01:29:59,480 --> 01:30:10,440
WE THOUGHT THE SET ASIDE AND

2246
01:30:10,440 --> 01:30:13,720
MECHANISM OF DOING THIS R24 WAS

2247
01:30:13,720 --> 01:30:14,600
APPROPRIATE AND GENERAL

2248
01:30:14,600 --> 01:30:19,000
DISCUSSION WAS QUITE SUPPORTIVE

2249
01:30:19,000 --> 01:30:20,280
OF THIS.

2250
01:30:20,280 --> 01:30:21,120
>> FANTASTIC.

2251
01:30:21,120 --> 01:30:23,240
ARE THERE OTHER COMMENTS FROM

2252
01:30:23,240 --> 01:30:26,760
COUNCIL ON THIS PARTICULAR

2253
01:30:26,760 --> 01:30:30,000
CONCEPT? 

2254
01:30:30,000 --> 01:30:30,760
OKAY.

2255
01:30:30,760 --> 01:30:33,080
HEARING OR SEEING NONE, I WOULD

2256
01:30:33,080 --> 01:30:36,280
LIKE FOR US TO MOVE FORWARD AND

2257
01:30:36,280 --> 01:30:43,000
VOTE ON THIS, THE VOTE IS TO

2258
01:30:43,000 --> 01:30:47,280
APPROVE THIS PARTICULAR CONCEPT 

2259
01:30:47,280 --> 01:30:47,520
CLEARANCE.

2260
01:30:47,520 --> 01:30:48,080
AL THOSE IN FAVOR?

2261
01:30:48,080 --> 01:30:49,040
>> AYE.

2262
01:30:49,040 --> 01:30:50,120
>> AYE.

2263
01:30:50,120 --> 01:30:50,440
>> AYE.

2264
01:30:50,440 --> 01:30:51,560
>> ANY OPPOSED?

2265
01:30:51,560 --> 01:30:52,240
OKAY.

2266
01:30:52,240 --> 01:30:54,600
SO THIS CONCEPT MOVES FORWARD AS

2267
01:30:54,600 --> 01:30:55,920
ACCEPTED BY COUNCIL.

2268
01:30:55,920 --> 01:30:56,360
OKAY.

2269
01:30:56,360 --> 01:30:59,440
SO THE NEXT GROUP IS FROM THE

2270
01:30:59,440 --> 01:31:01,080
DIVISION OF NEUROSCIENCE.

2271
01:31:01,080 --> 01:31:02,960
THE FIRST CONCEPT THAT WE'LL

2272
01:31:02,960 --> 01:31:05,560
CONSIDER IS PRECISION MEDICINE

2273
01:31:05,560 --> 01:31:08,120
APPROACHES IN ADDRESSING AD/ADRD

2274
01:31:08,120 --> 01:31:10,280
MINORITY AND HEALTH AND HEALTH

2275
01:31:10,280 --> 01:31:10,720
DISPARITIES.

2276
01:31:10,720 --> 01:31:13,080
PRIME REVIEWER WAS JENNIFER

2277
01:31:13,080 --> 01:31:14,680
MANLY, SECONDARY WAS KEITH

2278
01:31:14,680 --> 01:31:15,080
WHITFIELD.

2279
01:31:15,080 --> 01:31:17,640
DR. MANLY, IF YOU CAN SUMMARIZE

2280
01:31:17,640 --> 01:31:20,880
THE CONCEPT AND THE DISCUSSION

2281
01:31:20,880 --> 01:31:21,280
FROM YESTERDAY.

2282
01:31:21,280 --> 01:31:26,880
>> YES, SO THIS IS A CONCEPT

2283
01:31:26,880 --> 01:31:28,480
CLEARANCE FOR UH2/UH3 AWARDS,

2284
01:31:28,480 --> 01:31:30,440
THAT WOULD ENCOURAGE DEVELOPMENT

2285
01:31:30,440 --> 01:31:33,680
OF STUDIES CAPABLE OF

2286
01:31:33,680 --> 01:31:35,680
INVESTIGATING PRECISION MEDICINE

2287
01:31:35,680 --> 01:31:38,280
AND THAT IS TREATMENT,

2288
01:31:38,280 --> 01:31:39,720
PREVENTION, AND INTERVENTION

2289
01:31:39,720 --> 01:31:42,880
METHODS THAT ADDRESS CAUSAL

2290
01:31:42,880 --> 01:31:44,080
PATHWAYS THAT INFLUENCE

2291
01:31:44,080 --> 01:31:47,040
DISPARITIES IN AD AND ADRD, SO

2292
01:31:47,040 --> 01:31:53,480
FOCUSED ON DISPARITIES IN AD AND

2293
01:31:53,480 --> 01:31:57,800
ADRD AND HAS A PRECISION

2294
01:31:57,800 --> 01:32:02,040
MEDICINE CONCEPT GOING THROUGH

2295
01:32:02,040 --> 01:32:02,200
IT.

2296
01:32:02,200 --> 01:32:04,440
THE CONCEPT CLEARANCE

2297
01:32:04,440 --> 01:32:06,680
DESCRIPTION AND THESE AWARDS

2298
01:32:06,680 --> 01:32:14,000
REALLY CENTER THE NIA HEALTH

2299
01:32:14,000 --> 01:32:15,000
DISPARITIES FRAMEWORK, AS

2300
01:32:15,000 --> 01:32:19,480
FUNDAMENTAL TO THE RATIONALE FOR

2301
01:32:19,480 --> 01:32:21,440
THE FUNDING OPPORTUNITY.

2302
01:32:21,440 --> 01:32:24,000
THE RESEARCH QUESTIONS PROPOSED

2303
01:32:24,000 --> 01:32:27,880
UNDER THE MECHANISM CAN SUPPORT

2304
01:32:27,880 --> 01:32:30,720
EMERGING AD OR ADRD STUDIES OR

2305
01:32:30,720 --> 01:32:32,880
ESTABLISHED STUDIES NOT

2306
01:32:32,880 --> 01:32:35,960
CURRENTLY A.D. FOCUSED BUT HAVE

2307
01:32:35,960 --> 01:32:38,840
POTENTIAL TO ADD KNOWLEDGE ABOUT

2308
01:32:38,840 --> 01:32:40,320
ALZHEIMER'S DISEASE.

2309
01:32:40,320 --> 01:32:42,800
FIRST PHASE OF EACH STUDY WOULD

2310
01:32:42,800 --> 01:32:45,080
BE PLANNING OR EXPLORATORY.

2311
01:32:45,080 --> 01:32:46,680
THAT'S THE UH2 PHASE.

2312
01:32:46,680 --> 01:32:48,640
AND CAN INCLUDE DEVELOPMENT OF

2313
01:32:48,640 --> 01:32:51,920
NEW TOOLS OR METHODS, DATA

2314
01:32:51,920 --> 01:32:53,800
COLLECTION, ENGAGEMENT OF

2315
01:32:53,800 --> 01:32:55,640
MEANINGFUL STAKEHOLDERS WHICH IS

2316
01:32:55,640 --> 01:32:58,040
INCREDIBLY IMPORTANT IN

2317
01:32:58,040 --> 01:33:00,680
DISPARITIES RESEARCH.

2318
01:33:00,680 --> 01:33:06,640
AND WHILE -- AND THE PROCESS

2319
01:33:06,640 --> 01:33:09,520
DURING THE UH2 PERIOD OF THE

2320
01:33:09,520 --> 01:33:12,200
AWARD IS REALLY DESCRIBED AS A

2321
01:33:12,200 --> 01:33:17,480
COMMUNITY ENGAGED APPROACH. 

2322
01:33:17,480 --> 01:33:18,560
SO, MINORITIYIZED COMMUNITIES

2323
01:33:18,560 --> 01:33:20,200
WOULD BE CENTERED AT EARLY STAGE

2324
01:33:20,200 --> 01:33:22,400
IN THE PROJECTS.

2325
01:33:22,400 --> 01:33:24,360
CONCEPT CLEARANCE DESCRIBES THE

2326
01:33:24,360 --> 01:33:25,440
DEFINITION OF INTERSECTIONALITY,

2327
01:33:25,440 --> 01:33:28,280
HOW THAT WOULD BE IMPLEMENTED BY

2328
01:33:28,280 --> 01:33:30,040
RESEARCHERS AT THIS DEVELOPMENT

2329
01:33:30,040 --> 01:33:31,680
STAGE.

2330
01:33:31,680 --> 01:33:34,840
THE CONCEPT CLEARANCE ALSO

2331
01:33:34,840 --> 01:33:39,640
DESCRIBES HOW THE CONCEPT OF

2332
01:33:39,640 --> 01:33:40,520
RESILIENCE IN MINORITIZED

2333
01:33:40,520 --> 01:33:45,560
POPULATIONS, RESEARCH IN DEVELOP

2334
01:33:45,560 --> 01:33:47,080
 DEVELOPMENTAL STAGE CAN ADDRESS

2335
01:33:47,080 --> 01:33:49,280
ISSUES. 

2336
01:33:49,280 --> 01:33:53,640
TEAMS BEING CALLED FOR ARE

2337
01:33:53,640 --> 01:33:55,160
DESCRIBED AS TRANSFORMATIVE,

2338
01:33:55,160 --> 01:33:57,680
MULTI-DISCIPLINARY, AND THEY CAN

2339
01:33:57,680 --> 01:34:00,000
INTEGRATE NEUROSCIENCE WITH

2340
01:34:00,000 --> 01:34:01,840
GENETIC OR BIOLOGICAL,

2341
01:34:01,840 --> 01:34:02,840
ENVIRONMENTAL, BEHAVIORAL AND

2342
01:34:02,840 --> 01:34:04,360
SOCIAL SCIENCE TO ADVANCE

2343
01:34:04,360 --> 01:34:05,840
UNDERSTANDING OF THESE CAUSAL

2344
01:34:05,840 --> 01:34:07,520
PATHWAYS AT THE MULTIPLE LEVELS

2345
01:34:07,520 --> 01:34:12,240
JUST LIKE WHAT WE ALL KNOW IS

2346
01:34:12,240 --> 01:34:14,920
DESCRIBED IN THE NIA HEALTH

2347
01:34:14,920 --> 01:34:15,640
DISPARITIES FRAMEWORK.

2348
01:34:15,640 --> 01:34:18,000
HEARKENING BACK TO DR.

2349
01:34:18,000 --> 01:34:22,480
WHITFIELD'S SUMMARY OF HIS TALK

2350
01:34:22,480 --> 01:34:24,400
TO US, THE CONCEPT CLEARANCE

2351
01:34:24,400 --> 01:34:26,480
STATES THAT THE PROPOSED

2352
01:34:26,480 --> 01:34:30,960
RESEARCH CAN FOCUS ON MULTIPLE

2353
01:34:30,960 --> 01:34:32,200
OR SINGLE MINORITIZED

2354
01:34:32,200 --> 01:34:34,040
POPULATIONS OR SUBGROUPS WITHIN

2355
01:34:34,040 --> 01:34:35,080
THESE POPULATIONS.

2356
01:34:35,080 --> 01:34:37,000
THE APPLICATION STATES THAT

2357
01:34:37,000 --> 01:34:40,840
MEMBERS OF THE INVESTIGATIVE

2358
01:34:40,840 --> 01:34:43,000
TEAM SHOULD DEMONSTRATE BEFORE

2359
01:34:43,000 --> 01:34:46,080
APPLYING A TRACK RECORD OF

2360
01:34:46,080 --> 01:34:48,880
WORKING WITH COMMUNITIES IN AN

2361
01:34:48,880 --> 01:34:51,960
ENGAGED WAY TO DEVELOP RESEARCH

2362
01:34:51,960 --> 01:34:52,400
PRIORITIES.

2363
01:34:52,400 --> 01:34:58,280
THE COUNCIL FELT THAT THIS WAS

2364
01:34:58,280 --> 01:34:59,720
AN EXTREMELY TIMELY TOPIC THAT

2365
01:34:59,720 --> 01:35:03,680
THERE WERE A NUMBER OF

2366
01:35:03,680 --> 01:35:04,960
MILESTONES AND PRIORITIES AT NIA

2367
01:35:04,960 --> 01:35:06,320
THAT WERE ADDRESSED BY THIS

2368
01:35:06,320 --> 01:35:07,040
TOPIC.

2369
01:35:07,040 --> 01:35:11,920
WE WERE ALL VERY EXCITED ABOUT

2370
01:35:11,920 --> 01:35:12,680
IT.

2371
01:35:12,680 --> 01:35:17,680
AND THAT THE COOPERATIVE UH2/UH3

2372
01:35:17,680 --> 01:35:20,000
PHASED COOPERATIVE AGREEMENT

2373
01:35:20,000 --> 01:35:22,400
MECHANISM WAS APPROPRIATE FOR

2374
01:35:22,400 --> 01:35:24,080
THIS CALL FOR APPLICATIONS,

2375
01:35:24,080 --> 01:35:25,920
FIRST HAVING A FEASIBILITY

2376
01:35:25,920 --> 01:35:29,200
STAGE, AND THEN HAVING A PILOT

2377
01:35:29,200 --> 01:35:33,560
DATA COLLECTION PHASE.

2378
01:35:33,560 --> 01:35:35,520
SO, THAT SUMMARIZES THE CONCEPT

2379
01:35:35,520 --> 01:35:36,640
CLEARANCE, OUR DISCUSSION WAS

2380
01:35:36,640 --> 01:35:40,720
THAT IT WAS REALLY EXCITING.

2381
01:35:40,720 --> 01:35:41,760
AND THAT'S MY SUMMARY.

2382
01:35:41,760 --> 01:35:42,880
>> GREAT.

2383
01:35:42,880 --> 01:35:48,800
THANK YOU VERY MUCH.

2384
01:35:48,800 --> 01:35:51,480
DOES COUNCIL HAVE ANY ADDITIONAL

2385
01:35:51,480 --> 01:35:53,000
COMMENT ON THIS CONCEPT?

2386
01:35:53,000 --> 01:35:54,960
>> MONICA, I WAS SECONDARY ON

2387
01:35:54,960 --> 01:35:57,200
THAT, THE ONLY THING I WOULD ADD

2388
01:35:57,200 --> 01:36:00,120
IS THAT I JUST ADDED A COMMENT

2389
01:36:00,120 --> 01:36:03,080
ABOUT MAKING SURE THERE WAS

2390
01:36:03,080 --> 01:36:04,920
APPROPRIATE ATTENTION TO SUBJECT

2391
01:36:04,920 --> 01:36:06,160
RECRUITMENT, JUST GIVEN THE

2392
01:36:06,160 --> 01:36:08,440
CHALLENGES THAT THAT CAN BE IN

2393
01:36:08,440 --> 01:36:09,840
SOME MINORITY POPULATIONS, BUT I

2394
01:36:09,840 --> 01:36:11,080
FELT CONFIDENT FROM THE RESPONSE

2395
01:36:11,080 --> 01:36:12,640
FROM PROGRAM THAT THAT WAS GOING

2396
01:36:12,640 --> 01:36:13,880
TO BE ADDRESSED.

2397
01:36:13,880 --> 01:36:16,040
>> GREAT.

2398
01:36:16,040 --> 01:36:16,280
EXCELLENT.

2399
01:36:16,280 --> 01:36:19,520
VERY GOOD POINT.

2400
01:36:19,520 --> 01:36:22,520
OTHER COMMENTS?

2401
01:36:22,520 --> 01:36:22,720
OKAY.

2402
01:36:22,720 --> 01:36:27,520
NOT HEARING ANY, I WOULD MOVE TO

2403
01:36:27,520 --> 01:36:29,680
ACCEPT THIS CONCEPT CLEARANCE.

2404
01:36:29,680 --> 01:36:33,360
THOSE WHO ARE IN FAVOR, AYE?

2405
01:36:33,360 --> 01:36:34,680
>> AYE.

2406
01:36:34,680 --> 01:36:34,960
>> AYE.

2407
01:36:34,960 --> 01:36:37,480
>> AYE.

2408
01:36:37,480 --> 01:36:38,640
>> ANY OPPOSED?

2409
01:36:38,640 --> 01:36:39,280
OKAY.

2410
01:36:39,280 --> 01:36:42,640
NOT HEARING ANY OPPOSITION, THIS

2411
01:36:42,640 --> 01:36:43,320
CONCEPT MOVES FORWARD AS

2412
01:36:43,320 --> 01:36:44,200
APPROVED BY COUNCIL.

2413
01:36:44,200 --> 01:36:48,880
WE'LL MOVE TO THE NEXT

2414
01:36:48,880 --> 01:36:49,680
APPLICATION, NEURONAL

2415
01:36:49,680 --> 01:36:55,240
VULNERABILITY TO PROTEINOPATHIES

2416
01:36:55,240 --> 01:37:00,480
IN ALZHEIMER'S DISEASE AND

2417
01:37:00,480 --> 01:37:01,960
ALZHEIMER'S DISEASE-RELATED

2418
01:37:01,960 --> 01:37:02,280
DEPARTMENTS.

2419
01:37:02,280 --> 01:37:05,080
DR. HUANG, IF YOU WANT TO

2420
01:37:05,080 --> 01:37:07,760
SUMMARIZE THE CONCEPT AND THE

2421
01:37:07,760 --> 01:37:11,680
DISCUSSION FROM YESTERDAY.

2422
01:37:11,680 --> 01:37:11,920
>> YES.

2423
01:37:11,920 --> 01:37:12,960
SO, THIS CONCEPT CLEARANCE

2424
01:37:12,960 --> 01:37:18,440
PROPOSED TO USE THE R01 ACTIVITY

2425
01:37:18,440 --> 01:37:20,840
CODE TO SUPPORT SPECIFY

2426
01:37:20,840 --> 01:37:22,360
PROJECTS, CHARACTERIZING

2427
01:37:22,360 --> 01:37:24,760
NEURONAL AND GLIAL CELL

2428
01:37:24,760 --> 01:37:27,840
POPULATION SELECT OR VULNERABLE

2429
01:37:27,840 --> 01:37:32,080
TO PROTEINOPATHY, AD AND ADRD.

2430
01:37:32,080 --> 01:37:34,600
REVIEWERS ON COUNCIL GENERALLY

2431
01:37:34,600 --> 01:37:38,400
AGREED THIS COUNSEL CLEARANCE

2432
01:37:38,400 --> 01:37:39,520
TARGETED ONE VERY IMPORTANT

2433
01:37:39,520 --> 01:37:43,680
UNANSWERED QUESTION IN THIS

2434
01:37:43,680 --> 01:37:43,960
FIELD.

2435
01:37:43,960 --> 01:37:46,080
AND ESPECIALLY RECOGNIZED THIS

2436
01:37:46,080 --> 01:37:49,080
IS TIMELY, ESPECIALLY DUE TO THE

2437
01:37:49,080 --> 01:37:56,560
CURRENT ADVANCEMENT OF SINGLE

2438
01:37:56,560 --> 01:37:59,440
CELL TRANSCRIPTOMIC EPIGENOMIC

2439
01:37:59,440 --> 01:38:01,280
AND SPATIAL TECHNOLOGY WHICH NOW

2440
01:38:01,280 --> 01:38:04,000
CAN USE TO CHARACTERIZE CELL

2441
01:38:04,000 --> 01:38:09,080
TIMES AT A MOLECULAR LEVEL AND

2442
01:38:09,080 --> 01:38:09,400
RESOLUTION.

2443
01:38:09,400 --> 01:38:13,560
SO, THE REVIEWER AND COUNCIL

2444
01:38:13,560 --> 01:38:17,400
ALSO RECOGNIZED VERY UNIQUE

2445
01:38:17,400 --> 01:38:20,560
FEATURE IN THIS CONCEPT

2446
01:38:20,560 --> 01:38:22,960
CLEARANCE THAT IS ENCOURAGE

2447
01:38:22,960 --> 01:38:25,160
COLLABORATION WITH INVESTIGATORS

2448
01:38:25,160 --> 01:38:30,480
WHO ARE CURRENTLY FUNDED BY THE

2449
01:38:30,480 --> 01:38:32,880
BRIDGE INITIATIVE AND ALSO

2450
01:38:32,880 --> 01:38:34,320
VIEWED ON EXISTING REFERENCE

2451
01:38:34,320 --> 01:38:37,520
BRAIN ATLAS AND DATABASE AND

2452
01:38:37,520 --> 01:38:39,920
ALSO ENCOURAGING GENERAL SHARE

2453
01:38:39,920 --> 01:38:42,320
OF THE DATA.

2454
01:38:42,320 --> 01:38:45,840
SO, DURING THE DISCUSSION THERE

2455
01:38:45,840 --> 01:38:48,120
WAS ONE CLEARANCE REQUIRED, AND

2456
01:38:48,120 --> 01:38:49,440
THE PROGRAM OFFICER ADDRESSED

2457
01:38:49,440 --> 01:38:52,280
THAT VERY CLEARLY.

2458
01:38:52,280 --> 01:38:55,560
THAT IS WHETHER THIS CONCEPT

2459
01:38:55,560 --> 01:39:02,160
ONLY COVER THE TAUOPATHY OR 

2460
01:39:02,160 --> 01:39:03,840
OTHEROPATHYS, PROTEINOPATHIES,

2461
01:39:03,840 --> 01:39:05,240
INCLUDING TGP 43 OR

2462
01:39:05,240 --> 01:39:10,280
ALPHA-SYNUCLEIN, AND THE PROGRAM

2463
01:39:10,280 --> 01:39:13,320
OFFICER ADDRESSED CLEARLY NOT

2464
01:39:13,320 --> 01:39:14,760
JUST TAUOPATHY BUT OTHER

2465
01:39:14,760 --> 01:39:17,840
PROTEINOPATHIES, SO THE SUMMARY

2466
01:39:17,840 --> 01:39:20,040
THE COUNCIL WAS VERY SUPPORTIVE

2467
01:39:20,040 --> 01:39:22,160
OF THE CONCEPT CLEARANCE.

2468
01:39:22,160 --> 01:39:23,720
>> THANK YOU VERY MUCH.

2469
01:39:23,720 --> 01:39:29,720
ARE THERE OTHER COMMENTS ON THIS

2470
01:39:29,720 --> 01:39:30,080
CONCEPT?

2471
01:39:30,080 --> 01:39:35,280
OKAY, NOT HEARING OR SEEING ANY,

2472
01:39:35,280 --> 01:39:38,880
I WOULD INVITE PEOPLE TO VOTE ON

2473
01:39:38,880 --> 01:39:41,200
THE APPROVAL OF THIS CONCEPT.

2474
01:39:41,200 --> 01:39:42,120
ALL THOSE IN FAVOR?

2475
01:39:42,120 --> 01:39:43,440
>>  AYE.

2476
01:39:43,440 --> 01:39:44,360
>> AYE.

2477
01:39:44,360 --> 01:39:47,760
>> AYE. 

2478
01:39:47,760 --> 01:39:48,120
>> AYE.

2479
01:39:48,120 --> 01:39:49,080
>> ANY OPPOSED?

2480
01:39:49,080 --> 01:39:49,440
OKAY.

2481
01:39:49,440 --> 01:39:52,240
SO NOT HEARING ANY, THIS CONCEPT

2482
01:39:52,240 --> 01:39:55,720
IS APPROVED BY COUNCIL VOTE.

2483
01:39:55,720 --> 01:39:59,480
THE NEXT APPLICATION -- THE NEXT

2484
01:39:59,480 --> 01:40:00,760
CONCEPT IS DEMONSTRATION

2485
01:40:00,760 --> 01:40:03,480
PROJECTS TO PROMOTE ALLS OF

2486
01:40:03,480 --> 01:40:04,600
INTERPRACTICABLE HEALTH RECORDS

2487
01:40:04,600 --> 01:40:07,640
IN CLINICAL RESEARCH IN OLDER

2488
01:40:07,640 --> 01:40:09,960
ADULTS.

2489
01:40:09,960 --> 01:40:11,280
THE PRIMARY REVIEWER WAS DAVID

2490
01:40:11,280 --> 01:40:19,800
REUBEN, SECOND REVIEWER WAS ERIC

2491
01:40:19,800 --> 01:40:20,240
REIMANN.

2492
01:40:20,240 --> 01:40:23,280
DR. REUBEN IF YOU CAN SUMMARIZE

2493
01:40:23,280 --> 01:40:24,600
THE CONCEPT AND NATURE OF

2494
01:40:24,600 --> 01:40:25,120
DISCUSSION.

2495
01:40:25,120 --> 01:40:27,040
>> THIS IS A VERY INTERESTING

2496
01:40:27,040 --> 01:40:29,320
CONCEPT. 

2497
01:40:29,320 --> 01:40:32,280
IT ADDRESSES AN ISSUE THAT HAS

2498
01:40:32,280 --> 01:40:34,440
REALLY BEEN DEFICIENCY AND

2499
01:40:34,440 --> 01:40:35,680
PROBLEM WITH HOW ELECTRONIC

2500
01:40:35,680 --> 01:40:37,280
HEALTH RECORDS HAVE BEEN

2501
01:40:37,280 --> 01:40:40,400
DEVELOPED IN THE UNITED STATES.

2502
01:40:40,400 --> 01:40:43,480
THEY ARE NOT VERY

2503
01:40:43,480 --> 01:40:45,200
INTEROPEARABLE, NUMBER ONE.

2504
01:40:45,200 --> 01:40:46,680
NUMBER TWO, THEY DON'T COLLECT

2505
01:40:46,680 --> 01:40:49,840
DATA, VERY IMPORTANT DATA, USING

2506
01:40:49,840 --> 01:40:52,200
DEFINED FIELDS THAT ARE

2507
01:40:52,200 --> 01:40:52,600
EXPORTABLE.

2508
01:40:52,600 --> 01:40:56,240
SO THIS ATTEMPTS TO REMEDY SOME

2509
01:40:56,240 --> 01:40:59,640
OF THIS BY ALLOWING RESEARCH

2510
01:40:59,640 --> 01:41:00,480
PARTICIPANTS TO DONATE THEIR

2511
01:41:00,480 --> 01:41:06,400
ELECTRONIC HEALTH RECORD, AND

2512
01:41:06,400 --> 01:41:10,480
THEN HAVING THE AWARDEES, GRANT

2513
01:41:10,480 --> 01:41:16,040
AWARDEES, CREATE ESSENTIALLY A

2514
01:41:16,040 --> 01:41:17,680
DATABASE OF THE INFORMATION

2515
01:41:17,680 --> 01:41:20,680
PARTICULARLY RELATED TO MEDICAL

2516
01:41:20,680 --> 01:41:22,640
HISTORY, MEDICAL CONDITIONS,

2517
01:41:22,640 --> 01:41:23,800
SELF-REPORTED CONDITIONS, THAT

2518
01:41:23,800 --> 01:41:28,520
WILL BE VERY USEFUL TO THE

2519
01:41:28,520 --> 01:41:29,480
RESEARCH.

2520
01:41:29,480 --> 01:41:31,880
ONE OF THE CAVEATS, IT HAS TO BE

2521
01:41:31,880 --> 01:41:36,640
ABLE TO ACCOMMODATE ALL OF THESE

2522
01:41:36,640 --> 01:41:37,920
ELECTRONIC HEALTH RECORDS.

2523
01:41:37,920 --> 01:41:40,200
FOUR ACCOUNT FOR 77% OF ALL

2524
01:41:40,200 --> 01:41:44,760
ELECTRONIC HEALTH RECORDS IN THE

2525
01:41:44,760 --> 01:41:46,200
UNITED STATES.

2526
01:41:46,200 --> 01:41:50,040
THIS WAS SUPPORTED IN GENERAL IN

2527
01:41:50,040 --> 01:41:51,680
THE DISCUSSION, AND BY DR.

2528
01:41:51,680 --> 01:41:54,080
REIMANN AS WELL.

2529
01:41:54,080 --> 01:41:56,800
WE ALSO -- ANY LED TO

2530
01:41:56,800 --> 01:41:58,440
INTERESTING QUESTION ABOUT

2531
01:41:58,440 --> 01:42:00,400
GETTING THE EHR VENDORS INVOLVED

2532
01:42:00,400 --> 01:42:03,680
IN THIS, AND TO DATE NONE OF THE

2533
01:42:03,680 --> 01:42:06,320
MAJOR VENDORS HAVE ACTUALLY BEEN

2534
01:42:06,320 --> 01:42:09,680
LEADS IN NIA GRANTS, BUT IN FACT

2535
01:42:09,680 --> 01:42:11,520
COLLABORATION WITH THEM WOULD BE

2536
01:42:11,520 --> 01:42:12,400
VERY VALUABLE.

2537
01:42:12,400 --> 01:42:15,360
THAT'S ANOTHER WAY TO APPROACH

2538
01:42:15,360 --> 01:42:18,440
THIS DEFICIENCY OF GETTING

2539
01:42:18,440 --> 01:42:20,400
CLINICAL DATA INTO CLINICAL

2540
01:42:20,400 --> 01:42:20,880
RESEARCH.

2541
01:42:20,880 --> 01:42:21,880
SO OVERALL WE WERE QUITE

2542
01:42:21,880 --> 01:42:23,560
SUPPORTIVE OF THIS.

2543
01:42:23,560 --> 01:42:27,360
THE MECHANISM WILL BE THROUGH

2544
01:42:27,360 --> 01:42:29,680
THE R01 ACTIVITY CODE, AND IT'S

2545
01:42:29,680 --> 01:42:34,600
ANTICIPATED SOME OF THESE WILL

2546
01:42:34,600 --> 01:42:36,640
BE ALZHEIMER'S AND DEMENTIA,

2547
01:42:36,640 --> 01:42:39,240
DISORDERS RELATED, AND SOME OF

2548
01:42:39,240 --> 01:42:40,280
THEM WON'T.

2549
01:42:40,280 --> 01:42:41,720
>> OKAY.

2550
01:42:41,720 --> 01:42:43,320
THANK YOU VERY MUCH.

2551
01:42:43,320 --> 01:42:48,480
ARE THERE OTHER COMMENTS FROM

2552
01:42:48,480 --> 01:42:51,240
COUNCIL?  NOT HEARING ANY, I

2553
01:42:51,240 --> 01:42:59,560
WOULD PROPOSE THAT WE VOTE TO

2554
01:42:59,560 --> 01:43:03,120
ACCEPT THIS CONCEPT CLEARANCE.

2555
01:43:03,120 --> 01:43:03,680
IN FAVOR?

2556
01:43:03,680 --> 01:43:04,680
>> YES.

2557
01:43:04,680 --> 01:43:07,160
>> AYE.

2558
01:43:07,160 --> 01:43:08,080
>> AYE.

2559
01:43:08,080 --> 01:43:10,720
>> ANY OPPOSED?

2560
01:43:10,720 --> 01:43:11,280
OKAY.

2561
01:43:11,280 --> 01:43:12,520
THEN THIS CONCEPT MOVES FORWARD

2562
01:43:12,520 --> 01:43:15,680
AS APPROVED BY COUNCIL.

2563
01:43:15,680 --> 01:43:19,200
THE FINAL CONCEPT CLEARANCE HAS 

2564
01:43:19,200 --> 01:43:24,720
A LOT OF LETTERS IN THE TITLE,

2565
01:43:24,720 --> 01:43:29,680
AND IS NIA, AD, ADRD, SBIR, STTR

2566
01:43:29,680 --> 01:43:31,640
REISSUE, ADVANCING RESEARCH ON

2567
01:43:31,640 --> 01:43:34,480
AD AND ADRD.

2568
01:43:34,480 --> 01:43:43,440
THE PRIMARY REVIEWER WAS DR.

2569
01:43:43,440 --> 01:43:47,840
REIMANN, SECONDARY WAS DR.

2570
01:43:47,840 --> 01:43:49,080
COMER, DR. REIMANN, SUMMARIZE

2571
01:43:49,080 --> 01:43:51,280
THE CONCEPT AND DISCUSSION FROM

2572
01:43:51,280 --> 01:43:52,120
YESTERDAY.

2573
01:43:52,120 --> 01:43:53,160
>> THANKS, MONICA.

2574
01:43:53,160 --> 01:43:56,680
THIS CONCEPT WOULD REISSUE THE

2575
01:43:56,680 --> 01:43:59,840
SMALL BUSINESS INNOVATION

2576
01:43:59,840 --> 01:44:02,560
RESEARCH, SMALL BUSINESS

2577
01:44:02,560 --> 01:44:04,480
TECHNOLOGY TRANSFER PROGRAMS FOR

2578
01:44:04,480 --> 01:44:08,040
ALZHEIMER'S DISEASE, ALZHEIMER'S

2579
01:44:08,040 --> 01:44:09,440
DISEASE RELATED DEMENTIAS.

2580
01:44:09,440 --> 01:44:13,280
BEFORE THEY ARE SET TO EXPIRE IN

2581
01:44:13,280 --> 01:44:14,880
SEPTEMBER 2022.

2582
01:44:14,880 --> 01:44:17,720
SBIR AND STTR GRANTS SUPPORT THE

2583
01:44:17,720 --> 01:44:19,840
DEVELOPMENT OF PRODUCTS OR

2584
01:44:19,840 --> 01:44:22,760
SERVICES IN AREAS OF ALZHEIMER'S

2585
01:44:22,760 --> 01:44:25,640
DISEASE AND RELATED DEMENTIA

2586
01:44:25,640 --> 01:44:26,600
TREATMENT, PREVENTION,

2587
01:44:26,600 --> 01:44:28,680
DIAGNOSIS, CARE, RESEARCH, AND

2588
01:44:28,680 --> 01:44:29,240
CLINICAL TOOLS.

2589
01:44:29,240 --> 01:44:31,960
PHASE 1 GRANTS ARE INTENDED TO

2590
01:44:31,960 --> 01:44:33,280
DEMONSTRATE TECHNICAL MERIT AND

2591
01:44:33,280 --> 01:44:35,480
FEASIBILITY OF THE PRODUCT OR

2592
01:44:35,480 --> 01:44:36,880
SERVICE AND QUALITY PERFORMANCE

2593
01:44:36,880 --> 01:44:38,760
OF THE SMALL BUSINESS ITSELF,

2594
01:44:38,760 --> 01:44:41,360
WHEREAS THE PHASE 2 AND 2B

2595
01:44:41,360 --> 01:44:43,560
GRANTS ARE INTENDED TO FURTHER

2596
01:44:43,560 --> 01:44:45,280
DEVELOP THE PRODUCT OR SERVICE,

2597
01:44:45,280 --> 01:44:47,840
PROPOSED PROGRAMS WOULD CONTINUE

2598
01:44:47,840 --> 01:44:50,680
TO USE CONGRESSIONALLY MANDATED

2599
01:44:50,680 --> 01:44:52,080
SET-ASIDE FUNDS, AVERAGING $20

2600
01:44:52,080 --> 01:44:54,000
MILLION PER YEAR FOR SBIR GRANTS

2601
01:44:54,000 --> 01:44:57,760
AND $4 MILLION PER YEAR FOR STTR

2602
01:44:57,760 --> 01:45:03,920
GRANTS, THE GRANTS ARE CAPPED AT

2603
01:45:03,920 --> 01:45:08,680
500K, TOTAL COST, 2.5 MILLION

2604
01:45:08,680 --> 01:45:11,400
FOR PHASE 2, $3 MILLION FOR

2605
01:45:11,400 --> 01:45:13,200
PHASE 2B STUDIES.

2606
01:45:13,200 --> 01:45:16,080
THE PROGRAM ALSO CAPITALIZES ON

2607
01:45:16,080 --> 01:45:17,680
CONFERENCES, WORKSHOPS, NUMEROUS

2608
01:45:17,680 --> 01:45:21,480
INDIVIDUAL INTERACTIONS TO REACH

2609
01:45:21,480 --> 01:45:24,280
OUT TO EDUCATE AND HELP TRAIN

2610
01:45:24,280 --> 01:45:27,360
POTENTIAL APPLICANTS, RESULTING

2611
01:45:27,360 --> 01:45:29,040
IN IMPROVEMENT IN APPLICATION

2612
01:45:29,040 --> 01:45:30,960
QUALITY IN THE LAST THREE YEARS.

2613
01:45:30,960 --> 01:45:33,680
SINCE THE ORIGINAL FOAs THAT

2614
01:45:33,680 --> 01:45:37,160
WERE ISSUED IN 2017, THERE WAS

2615
01:45:37,160 --> 01:45:39,840
184% INCREASE IN THE NUMBER OF

2616
01:45:39,840 --> 01:45:41,800
THESE GRANTS.

2617
01:45:41,800 --> 01:45:44,960
COUNCIL MEMBERS EXPRESS STRONG

2618
01:45:44,960 --> 01:45:46,920
SUPPORT FOR THE REISSUE, AND IT

2619
01:45:46,920 --> 01:45:50,000
WAS NOTED THAT IN THOSE

2620
01:45:50,000 --> 01:45:55,560
INSTANCES IN WHICH BUDGETARY

2621
01:45:55,560 --> 01:45:57,000
LIMITATIONS MIGHT PREVENT

2622
01:45:57,000 --> 01:45:58,640
BUSINESSES FROM ACHIEVING THEIR

2623
01:45:58,640 --> 01:46:00,280
SCIENTIFIC GOALS WITH ADEQUATE

2624
01:46:00,280 --> 01:46:02,760
POWER, THERE WERE OTHER

2625
01:46:02,760 --> 01:46:03,960
MECHANISMS THAT COULD BE PURSUED

2626
01:46:03,960 --> 01:46:04,960
INDEPENDENT OF THIS.

2627
01:46:04,960 --> 01:46:08,000
SO THERE WAS A STRONG SUPPORT

2628
01:46:08,000 --> 01:46:12,720
FOR THE REISSUE OF THESE

2629
01:46:12,720 --> 01:46:13,280
PROGRAMS.

2630
01:46:13,280 --> 01:46:14,760
>> THANK YOU.

2631
01:46:14,760 --> 01:46:18,840
IS THERE OTHER COMMENT ON THIS

2632
01:46:18,840 --> 01:46:19,080
CONCEPT?

2633
01:46:19,080 --> 01:46:20,480
>>  IF I COULD ALSO MENTION ONE

2634
01:46:20,480 --> 01:46:22,760
OTHER THING DURING THE

2635
01:46:22,760 --> 01:46:24,200
DISCUSSION, MEMBERS ALSO NOTED

2636
01:46:24,200 --> 01:46:27,640
THE OPPORTUNITY TO LEVERAGE

2637
01:46:27,640 --> 01:46:28,440
BUSINESS-RELATED GRANTS AND

2638
01:46:28,440 --> 01:46:30,640
OTHER MECHANISMS, TO FOSTER

2639
01:46:30,640 --> 01:46:32,360
INNOVATION, ALSO THE INCLUSION

2640
01:46:32,360 --> 01:46:35,040
OF FEMALE INVESTIGATORS AND

2641
01:46:35,040 --> 01:46:35,840
INVESTIGATORS FROM

2642
01:46:35,840 --> 01:46:36,440
UNDERREPRESENTED GROUPS.

2643
01:46:36,440 --> 01:46:39,400
AND IT WAS -- WE HAD A NICE

2644
01:46:39,400 --> 01:46:40,560
DISCUSSION ABOUT WHAT NIA HAS

2645
01:46:40,560 --> 01:46:46,720
BEEN DOING IN THAT REGARD.

2646
01:46:46,720 --> 01:46:49,760
>> THANK YOU.

2647
01:46:49,760 --> 01:46:49,960
MERYL?

2648
01:46:49,960 --> 01:46:51,520
>> YES, JUST RESPECTFULLY, I

2649
01:46:51,520 --> 01:46:57,640
CANNOT CLAIM TO BE A DOCTOR OR

2650
01:46:57,640 --> 01:46:59,480
Ph.D., SO FOR THE RECORD, BUT

2651
01:46:59,480 --> 01:47:00,680
THANK YOU.

2652
01:47:00,680 --> 01:47:03,240
>> YES, YOU CERTAINLY IN OUR

2653
01:47:03,240 --> 01:47:05,960
EYES ARE ABOVE DOCTOR LEVEL.

2654
01:47:05,960 --> 01:47:09,240
SO THANK YOU. 

2655
01:47:09,240 --> 01:47:12,040
OTHER COMMENTS OR QUESTIONS?

2656
01:47:12,040 --> 01:47:16,760
IF NOT, I WOULD LIKE TO INVITE A

2657
01:47:16,760 --> 01:47:18,920
VOTE ON THIS CONCEPT FOR WHICH

2658
01:47:18,920 --> 01:47:21,120
THERE WAS CONSIDERABLE POSITIVE

2659
01:47:21,120 --> 01:47:22,600
ENTHUSIASM.

2660
01:47:22,600 --> 01:47:25,640
ALL THOSE WHO ARE IN FAVOR OF

2661
01:47:25,640 --> 01:47:26,720
ACCEPTING THIS CONCEPT?

2662
01:47:26,720 --> 01:47:27,400
>>  AYE.

2663
01:47:27,400 --> 01:47:27,680
>> AYE.

2664
01:47:27,680 --> 01:47:28,440
>> AYE.

2665
01:47:28,440 --> 01:47:32,400
>> AYE. 

2666
01:47:32,400 --> 01:47:32,680
>> OKAY.

2667
01:47:32,680 --> 01:47:32,960
ANY OPPOSED?

2668
01:47:32,960 --> 01:47:35,120
>>  AYE.

2669
01:47:35,120 --> 01:47:35,640
>> OKAY.

2670
01:47:35,640 --> 01:47:41,680
I'M NOT SURE IF THAT NEEDS TO BE

2671
01:47:41,680 --> 01:47:42,080
NOTED.

2672
01:47:42,080 --> 01:47:45,280
BUT IT SEEMS, KEN, THAT THE

2673
01:47:45,280 --> 01:47:50,280
MAJORITY VOTE IS IN FAVOR OF

2674
01:47:50,280 --> 01:47:54,280
ACCEPTING THIS CONCEPT.

2675
01:47:54,280 --> 01:47:54,960
>> OKAY.

2676
01:47:54,960 --> 01:47:55,240
>> YEAH.

2677
01:47:55,240 --> 01:47:58,160
AND THEN I THINK WE ARE DONE

2678
01:47:58,160 --> 01:48:00,680
WITH THE CONCEPTS.

2679
01:48:00,680 --> 01:48:03,520
THANK YOU ALL, REVIEWERS, AND

2680
01:48:03,520 --> 01:48:05,360
PANEL MEMBERS, FOR REALLY

2681
01:48:05,360 --> 01:48:09,280
INTERESTING AND I THINK

2682
01:48:09,280 --> 01:48:09,760
CONSTRUCTIVE DISCUSSION.

2683
01:48:09,760 --> 01:48:13,440
>> YES, I WOULD LIKE TO THANK

2684
01:48:13,440 --> 01:48:15,280
MONICA FOR HER LEADERSHIP ON

2685
01:48:15,280 --> 01:48:17,120
WORKING GROUP AND THANK ALL THE

2686
01:48:17,120 --> 01:48:19,320
MEMBERS FOR THEIR REVIEWS OF

2687
01:48:19,320 --> 01:48:20,720
THESE CONCEPTS.

2688
01:48:20,720 --> 01:48:24,480
I WANT TO REMIND EVERYONE THAT

2689
01:48:24,480 --> 01:48:26,520
THESE CONCEPTS THAT ARE APPROVED

2690
01:48:26,520 --> 01:48:28,760
BY COUNCIL WILL BE PUBLISHED ON

2691
01:48:28,760 --> 01:48:32,760
OUR WEBSITE, SO IF YOU JUST

2692
01:48:32,760 --> 01:48:34,040
GOOGLE NIA CONCEPTS, HOPEFULLY

2693
01:48:34,040 --> 01:48:37,040
WITHIN THE WEEK THEY WILL BE UP,

2694
01:48:37,040 --> 01:48:39,840
WITH MORE LENGTHY SUMMARY OF THE

2695
01:48:39,840 --> 01:48:41,400
CONCEPTS THEMSELVES AND A

2696
01:48:41,400 --> 01:48:42,480
PROGRAMMATIC CONTACT FOR EACH OF

2697
01:48:42,480 --> 01:48:44,920
THEM SO IF YOU'D LIKE TO HAVE

2698
01:48:44,920 --> 01:48:46,440
FURTHER DISCUSSION WITH PROGRAM

2699
01:48:46,440 --> 01:48:48,160
ON ANY OF THESE PLEASE CONTACT

2700
01:48:48,160 --> 01:48:49,840
THEM SO THEY WILL BE PUBLISHED

2701
01:48:49,840 --> 01:48:50,920
ON OUR WEBSITE.

2702
01:48:50,920 --> 01:48:54,720
YOU CAN GET AN EARLY START

2703
01:48:54,720 --> 01:48:55,400
THINKING ABOUT PERHAPS PROPOSALS

2704
01:48:55,400 --> 01:49:00,400
IN A -- THAT YOU WOULD LIKE TO

2705
01:49:00,400 --> 01:49:03,440
START INITIATING. 

2706
01:49:03,440 --> 01:49:04,400
ALL RIGHT.

2707
01:49:04,400 --> 01:49:08,920
SO, NEXT IN OUR AGENDA IS OUR

2708
01:49:08,920 --> 01:49:10,280
NEXT THREE SPEAKERS, BUT BEFORE

2709
01:49:10,280 --> 01:49:14,080
WE DO THAT I'D LIKE TO GIVE

2710
01:49:14,080 --> 01:49:16,400
EVERYONE A FIVE-MINUTE BREAK TO

2711
01:49:16,400 --> 01:49:20,760
STRETCH YOUR LEGS, SO IT IS NOW

2712
01:49:20,760 --> 01:49:21,520
11:50 EASTERN TIME.

2713
01:49:21,520 --> 01:49:24,480
I'D LIKE TO GIVE EVERYONE FIVE

2714
01:49:24,480 --> 01:49:25,560
MINUTES.

2715
01:49:25,560 --> 01:49:28,080
WE'LL RECONVENE AT 11:55, AND WE

2716
01:49:28,080 --> 01:49:30,200
WILL START WITH OUR NEXT

2717
01:49:30,200 --> 01:49:31,800
SPEAKER

2718
01:49:31,800 --> 01:49:33,160
>> WELCOME BACK.

2719
01:49:33,160 --> 01:49:38,360
WE'LL CONTINUE WITH OUR OPEN

2720
01:49:38,360 --> 01:49:38,600
SESSION.

2721
01:49:38,600 --> 01:49:40,880
I'D LIKE TO TURN THIS OVER TO

2722
01:49:40,880 --> 01:49:45,440
DR. HODES TO INTRODUCE OUR FIRST

2723
01:49:45,440 --> 01:49:45,680
SPEAKER.

2724
01:49:45,680 --> 01:49:45,920
RICHARD?

2725
01:49:45,920 --> 01:49:50,280
>>  YES, IT'S A PLEASURE TO

2726
01:49:50,280 --> 01:49:52,680
INTRODUCE DR. CLINTON WRIGHT

2727
01:49:52,680 --> 01:49:54,280
FROM NINDS, A VERY IMPORTANT

2728
01:49:54,280 --> 01:49:59,120
TOPIC AS WE'RE COPING WITH ACUTE

2729
01:49:59,120 --> 01:50:01,960
IMPACT OF SARS-COV-2 INFECTIONS,

2730
01:50:01,960 --> 01:50:04,920
IT'S CLEAR SEQUELAE INFECTION

2731
01:50:04,920 --> 01:50:05,560
HAVE BEEN PROMINENT,

2732
01:50:05,560 --> 01:50:07,520
PREDOMINANT, A SOURCE OF ONGOING

2733
01:50:07,520 --> 01:50:10,840
RESEARCH, CLINT HAS BEEN ONE OF

2734
01:50:10,840 --> 01:50:14,120
THE CO-LEADS IN THIS INITIATIVE,

2735
01:50:14,120 --> 01:50:16,040
NIH RECOVER INITIATIVE AND WILL

2736
01:50:16,040 --> 01:50:16,960
SPEAK TO US TODAY.

2737
01:50:16,960 --> 01:50:18,680
>> IT'S A PLEASURE TO BE HERE.

2738
01:50:18,680 --> 01:50:20,240
CAN YOU HEAR ME?

2739
01:50:20,240 --> 01:50:22,560
>>  LOUD AND CLEAR.

2740
01:50:22,560 --> 01:50:23,160
>> FANTASTIC.

2741
01:50:23,160 --> 01:50:24,160
YES, THANK YOU FOR INVITING ME

2742
01:50:24,160 --> 01:50:32,400
TO TALK TO YOU TODAY ABOUT

2743
01:50:32,400 --> 01:50:34,040
POST-ACUTE SEQUELAE OF COVID AND

2744
01:50:34,040 --> 01:50:35,680
RECOVER INITIATIVE, FIRST

2745
01:50:35,680 --> 01:50:36,440
TALKING ABOUT THE DEFINITION

2746
01:50:36,440 --> 01:50:38,640
BECAUSE THERE ARE A NUMBER OF

2747
01:50:38,640 --> 01:50:39,480
DEFINITIONS OUT THERE AND I

2748
01:50:39,480 --> 01:50:42,040
THINK A LOT OF PEOPLE HEARD THE

2749
01:50:42,040 --> 01:50:46,720
TERM LONG COVID USED BUT THE 

2750
01:50:46,720 --> 01:50:49,400
NIH IS USING POST-ACUTE SEQUELAE

2751
01:50:49,400 --> 01:50:52,160
OF COVID TO INCLUDE DIFFERENT

2752
01:50:52,160 --> 01:50:53,240
CONCEPTS LIKE MULTI-INFLAMMATORY

2753
01:50:53,240 --> 01:50:55,640
SYNDROME IN ADULTS AND CHILDREN,

2754
01:50:55,640 --> 01:50:57,520
AS WELL AS VERY INTERESTING

2755
01:50:57,520 --> 01:50:59,960
PROBLEM OF CONDITIONS THAT MAY

2756
01:50:59,960 --> 01:51:04,200
ARISE AS A CONSEQUENCE OF

2757
01:51:04,200 --> 01:51:05,240
SARS-COV-2 INFECTION THAT MIGHT

2758
01:51:05,240 --> 01:51:07,480
BE DIABETES OR MIGHT BE SOME

2759
01:51:07,480 --> 01:51:12,600
OTHER RISK FACTOR THAT MAY LEAD 

2760
01:51:12,600 --> 01:51:14,240
TO OTHER ORGAN DAMAGE.

2761
01:51:14,240 --> 01:51:16,080
CLEARLY SYMPTOMS CAN RANGE FROM

2762
01:51:16,080 --> 01:51:18,200
MILD TO SEVERE, AND SO THAT

2763
01:51:18,200 --> 01:51:19,840
REALLY NEEDS TO BE UNDERSTOOD

2764
01:51:19,840 --> 01:51:21,400
MUCH BETTER, AND A BROADER TERM

2765
01:51:21,400 --> 01:51:26,040
I THINK IS GOING TO BE HELPFUL

2766
01:51:26,040 --> 01:51:27,360
WITH THAT.

2767
01:51:27,360 --> 01:51:29,520
AND AGAIN MANY SYMPTOMS HAVE

2768
01:51:29,520 --> 01:51:34,040
BEEN DESCRIBED OVER THE YEARS.

2769
01:51:34,040 --> 01:51:35,680
SORRY, OVER THIS ACUTE PANDEMIC.

2770
01:51:35,680 --> 01:51:37,120
YOU COULD SEE SOME THEM LISTED

2771
01:51:37,120 --> 01:51:40,080
HERE, THIS IS ONLY REALLY A

2772
01:51:40,080 --> 01:51:41,360
SHORT LIST.

2773
01:51:41,360 --> 01:51:43,800
AND THE UNDERSTANDING IS QUITE

2774
01:51:43,800 --> 01:51:45,320
LIMITED BECAUSE OF THE VERY

2775
01:51:45,320 --> 01:51:47,240
SHORTENED TIME FRAME THAT WE'VE

2776
01:51:47,240 --> 01:51:50,440
HAD TO STUDY THIS PROBLEM.

2777
01:51:50,440 --> 01:51:52,840
>> I'M SORRY, DR. WRIGHT, IF I

2778
01:51:52,840 --> 01:51:53,640
COULD INTERRUPT.

2779
01:51:53,640 --> 01:51:56,800
WE DON'T HAVE YOUR SLIDES UP AT

2780
01:51:56,800 --> 01:51:58,880
THE MOMENT.

2781
01:51:58,880 --> 01:52:01,200
>> OH, THANKS FOR LETTING ME

2782
01:52:01,200 --> 01:52:01,400
KNOW.

2783
01:52:01,400 --> 01:52:02,040
>> YES.

2784
01:52:02,040 --> 01:52:04,040
ARE YOU SHARING YOUR SCREEN?

2785
01:52:04,040 --> 01:52:06,920
>>  I PRESSED THE BUTTON BUT I

2786
01:52:06,920 --> 01:52:08,720
THOUGHT -- SORRY ABOUT THAT.

2787
01:52:08,720 --> 01:52:11,480
I ASKED IF YOU COULD HEAR ME BUT

2788
01:52:11,480 --> 01:52:16,600
DIDN'T IF YOU COULD SEE WHAT I

2789
01:52:16,600 --> 01:52:17,560
WAS PRESENTING.

2790
01:52:17,560 --> 01:52:19,200
DO YOU SEE NOW?

2791
01:52:19,200 --> 01:52:22,120
>> YES, WE CAN SEE YOUR SLIDES.

2792
01:52:22,120 --> 01:52:24,520
>> MY APOLOGIES.

2793
01:52:24,520 --> 01:52:25,760
WELL, ANYWAY, I WILL SKIP

2794
01:52:25,760 --> 01:52:28,840
THROUGH WHAT I ALREADY SAID BUT

2795
01:52:28,840 --> 01:52:32,440
ESSENTIALLY THIS IS WHAT I SAID

2796
01:52:32,440 --> 01:52:34,160
ABOUT THE DEFINITION OF PAST, I

2797
01:52:34,160 --> 01:52:36,040
WAS TALKING ABOUT THE VARIED

2798
01:52:36,040 --> 01:52:43,000
SYMPTOMS AND THE NEED TO

2799
01:52:43,000 --> 01:52:44,080
CHARACTERIZE THAT.

2800
01:52:44,080 --> 01:52:46,040
THE EPIDEMIOLOGY PIECE HAS BEEN

2801
01:52:46,040 --> 01:52:47,280
A CHALLENGE.

2802
01:52:47,280 --> 01:52:50,120
WE NEED MORE ROBUST DATA IN THIS

2803
01:52:50,120 --> 01:52:55,880
AREA, AND THAT'S REALLY THE MAIN

2804
01:52:55,880 --> 01:52:57,560
PURPOSE OF RECOVER, BUT THE

2805
01:52:57,560 --> 01:53:00,560
STUDIES TO DATE AS MANY PEOPLE

2806
01:53:00,560 --> 01:53:02,800
ON THIS CALL ARE AWARE, HAVE

2807
01:53:02,800 --> 01:53:04,240
BEEN VERY HETEROGENEOUS, AND

2808
01:53:04,240 --> 01:53:07,160
MANY OF THEM HAVE HAD

2809
01:53:07,160 --> 01:53:08,680
SIGNIFICANT LIMITATIONS, EITHER

2810
01:53:08,680 --> 01:53:10,160
BECAUSE THE SAMPLE ADVISES HAVE

2811
01:53:10,160 --> 01:53:13,880
BEEN SMALL OR WORK HAS BEEN DONE

2812
01:53:13,880 --> 01:53:15,320
QUITE QUICKLY, PUBLISHED IN

2813
01:53:15,320 --> 01:53:17,480
PRE-PRINT FORM, AND MAY THE NEW

2814
01:53:17,480 --> 01:53:18,240
HAVE BEEN PEER REVIEWED, SO

2815
01:53:18,240 --> 01:53:26,240
WE'RE NOT SURE IF THOSE FINDINGS

2816
01:53:26,240 --> 01:53:27,800
WILL HOLD UP.

2817
01:53:27,800 --> 01:53:28,360
EPIDEMIOLOGY WILL DEPEND ON

2818
01:53:28,360 --> 01:53:28,880
DEFINITION USED.

2819
01:53:28,880 --> 01:53:30,680
THERE ARE A NUMBER OF

2820
01:53:30,680 --> 01:53:33,120
DEFINITIONS, LIKE I SAID, THAT

2821
01:53:33,120 --> 01:53:35,640
HAVE BEEN USED ACROSS

2822
01:53:35,640 --> 01:53:36,320
ORGANIZATIONS AND EVEN AGENCIES,

2823
01:53:36,320 --> 01:53:37,920
AND SO WE NEED TO BE MORE

2824
01:53:37,920 --> 01:53:39,880
HARMONIZED IN THE USE OF THOSE

2825
01:53:39,880 --> 01:53:43,600
DEFINITIONS OR BE CLEAR ABOUT

2826
01:53:43,600 --> 01:53:43,800
THEM.

2827
01:53:43,800 --> 01:53:50,120
AND THEN WE WANT TO RECOGNIZE 

2828
01:53:50,120 --> 01:53:51,640
THAT PASC DOES OCCUR IN

2829
01:53:51,640 --> 01:53:53,440
CHILDREN, MAY BE LESS FREQUENT

2830
01:53:53,440 --> 01:53:54,840
BUT MAY BE QUITE DIFFERENT.

2831
01:53:54,840 --> 01:53:58,280
WE WANTED TO MAKE SURE THAT THAT

2832
01:53:58,280 --> 01:54:00,120
WAS STUDIED IN ITS OWN RIGHT.

2833
01:54:00,120 --> 01:54:03,240
THIS STUDY I THINK IS AN

2834
01:54:03,240 --> 01:54:04,240
INTERESTING ONE THAT INCLUDED

2835
01:54:04,240 --> 01:54:07,240
ABOUT A QUARTER OF A MILLION

2836
01:54:07,240 --> 01:54:11,040
COVID-19 SURVIVORS THAT WERE

2837
01:54:11,040 --> 01:54:16,400
ASSESSED FOR PASC AFTER 30 DAYS

2838
01:54:16,400 --> 01:54:17,320
FROM INFECTION, AND 57 STUDIES

2839
01:54:17,320 --> 01:54:19,920
IF YOU LOOK AT THE PANELS ON THE

2840
01:54:19,920 --> 01:54:23,520
SLIDE YOU SEE THE ENORMOUS

2841
01:54:23,520 --> 01:54:25,920
VARIABILITY IN THE DIFFERENT

2842
01:54:25,920 --> 01:54:28,240
SYMPTOMS AND PROBLEMS THAT HAVE

2843
01:54:28,240 --> 01:54:30,560
COME OUT IN THE STUDY.

2844
01:54:30,560 --> 01:54:33,600
AND SO IT JUST HIGHLIGHTS THE

2845
01:54:33,600 --> 01:54:36,040
IMPORTANCE OF GETTING ALL OF OUR

2846
01:54:36,040 --> 01:54:38,440
HEADS TOGETHER, AND STUDYING

2847
01:54:38,440 --> 01:54:42,000
THIS IN AN ORGANIZED AND

2848
01:54:42,000 --> 01:54:43,480
HARMONIZED WAY.

2849
01:54:43,480 --> 01:54:46,320
WHAT IS THE PREVALENCE OF PASC?

2850
01:54:46,320 --> 01:54:48,280
THAT IS OBVIOUSLY SOMETHING THAT

2851
01:54:48,280 --> 01:54:51,240
IS REALLY AN ITERATIVE PROCESS

2852
01:54:51,240 --> 01:54:53,640
OF TRYING TO UNDERSTAND, THIS

2853
01:54:53,640 --> 01:54:56,440
STUDY OUT OF THE U.K. THAT

2854
01:54:56,440 --> 01:54:58,240
INVOLVED MORE THAN 300,000

2855
01:54:58,240 --> 01:54:59,840
PEOPLE THAT ANSWERED A SURVEY,

2856
01:54:59,840 --> 01:55:02,360
YOU CAN SEE THAT IN THE

2857
01:55:02,360 --> 01:55:05,440
BEGINNING ABOUT 30 DAYS OUT FROM

2858
01:55:05,440 --> 01:55:08,400
INFECTION, ALMOST A FIFTH OF THE

2859
01:55:08,400 --> 01:55:12,080
POPULATION THAT HAS BEEN

2860
01:55:12,080 --> 01:55:13,520
INFECTED COMPLAINS OF SYMPTOMS

2861
01:55:13,520 --> 01:55:14,880
THAT HAVE LASTED THAT LONG, AND

2862
01:55:14,880 --> 01:55:18,480
THEN OVER THE NEXT COUPLE OF

2863
01:55:18,480 --> 01:55:21,440
MONTHS THAT DROPS DOWN, AND

2864
01:55:21,440 --> 01:55:23,760
SEEMS LIKE IT LEVELS ON OF, ENDS

2865
01:55:23,760 --> 01:55:26,160
UP AT 12% IN THIS ONE STUDY, BUT

2866
01:55:26,160 --> 01:55:28,240
ONE OF THE THINGS THAT IS VERY

2867
01:55:28,240 --> 01:55:29,320
INTERESTING ABOUT IT, AND ALSO

2868
01:55:29,320 --> 01:55:31,440
MAKES IT A CHALLENGE TO STUDY,

2869
01:55:31,440 --> 01:55:35,120
IS THAT IT SEEMS TO VARY BY THE

2870
01:55:35,120 --> 01:55:38,840
SEVERITY OF THE ILLNESS, SO YOU

2871
01:55:38,840 --> 01:55:41,320
CAN SEE THAT THE SYMPTOMS

2872
01:55:41,320 --> 01:55:43,120
CONSISTENTLY GREATER IN PEOPLE

2873
01:55:43,120 --> 01:55:44,840
WITH POOR BASELINE HEALTH AND

2874
01:55:44,840 --> 01:55:46,960
MORE SEVERE ACUTE INFECTION, AND

2875
01:55:46,960 --> 01:55:49,360
THE LITTLE PANEL TO THE RIGHT

2876
01:55:49,360 --> 01:55:51,240
WITH THE COLOR-CODED BARS SHOW

2877
01:55:51,240 --> 01:55:54,680
YOU THAT IF PEOPLE WERE NOT

2878
01:55:54,680 --> 01:55:55,520
HOSPITALIZED, THE RATES WERE

2879
01:55:55,520 --> 01:55:58,200
MUCH LOWER THAN THOSE WHO WERE

2880
01:55:58,200 --> 01:55:59,880
EITHER HOSPITALIZED OR PUT IN

2881
01:55:59,880 --> 01:56:02,440
INTENSIVE CARE BECAUSE OF THE

2882
01:56:02,440 --> 01:56:03,040
COVID-19.

2883
01:56:03,040 --> 01:56:05,640
SO IT COMPLICATES THE

2884
01:56:05,640 --> 01:56:07,400
UNDERSTANDING OF PASC.

2885
01:56:07,400 --> 01:56:09,120
AND THIS SLIDE, ALTHOUGH YOU

2886
01:56:09,120 --> 01:56:11,280
DON'T NEED TO READ EACH EVERY

2887
01:56:11,280 --> 01:56:18,680
ROW, WHAT IT SHOWS IS ACROSS THE

2888
01:56:18,680 --> 01:56:23,280
NON-HOSPITALIZED/HOSPITALIZED AT

2889
01:56:23,280 --> 01:56:25,680
ICU, DARKER RED AND PURPLE SHOW

2890
01:56:25,680 --> 01:56:27,400
MORE HEAVY BURDEN OF THE

2891
01:56:27,400 --> 01:56:28,960
SYMPTOMS, YOU CAN SEE THEY

2892
01:56:28,960 --> 01:56:30,680
GENERALLY KIND OF GO UP WITH

2893
01:56:30,680 --> 01:56:32,360
SEVERITY OF THE ILLNESS.

2894
01:56:32,360 --> 01:56:35,640
BUT I ALSO PUT THESE PANELS HERE

2895
01:56:35,640 --> 01:56:37,280
BECAUSE THEY ACTUALLY HIGHLIGHT

2896
01:56:37,280 --> 01:56:39,240
THE AGE GROUPS THAT I THOUGHT

2897
01:56:39,240 --> 01:56:42,800
THE NIA WOULD BE INTERESTED IN

2898
01:56:42,800 --> 01:56:43,840
BECAUSE THIS TABLE'S MUCH

2899
01:56:43,840 --> 01:56:45,960
LARGER, THIS LOOKS AT PEOPLE

2900
01:56:45,960 --> 01:56:48,120
LESS THAN 60, 60 TO 70, GREATER

2901
01:56:48,120 --> 01:56:48,640
THAN 70.

2902
01:56:48,640 --> 01:56:50,840
WHAT I THOUGHT WAS INTERESTING

2903
01:56:50,840 --> 01:56:53,360
ABOUT THIS IS THAT IN SOME OF

2904
01:56:53,360 --> 01:56:55,640
THE CASES, THE SYMPTOMS SEEM TO

2905
01:56:55,640 --> 01:56:57,840
GET WORSE AS PEOPLE GET OLDER.

2906
01:56:57,840 --> 01:57:00,360
BUT IN SOME CASES THEY SEEM TO

2907
01:57:00,360 --> 01:57:02,160
BE WORSE IN YOUNGER GROUPS.

2908
01:57:02,160 --> 01:57:04,480
AND SO THAT'S ALSO SOMETHING

2909
01:57:04,480 --> 01:57:07,200
THAT NEEDS TO BE REALLY

2910
01:57:07,200 --> 01:57:10,080
UNDERSTOOD A LOT BETTER.

2911
01:57:10,080 --> 01:57:11,920
SO, THE PERSISTENCE OF SYMPTOMS

2912
01:57:11,920 --> 01:57:14,000
HAS BEEN STUDIED IN RANDOM SORT

2913
01:57:14,000 --> 01:57:15,520
OF COMMUNITY-BASED SAMPLES LIKE

2914
01:57:15,520 --> 01:57:17,400
I MENTIONED EARLIER, AND THIS

2915
01:57:17,400 --> 01:57:19,880
ONE ALSO FROM THE U.K., MORE

2916
01:57:19,880 --> 01:57:22,960
THAN HALF A MILLION PEOPLE, THE

2917
01:57:22,960 --> 01:57:24,240
PREVALENCE OF SELF-REPORTED

2918
01:57:24,240 --> 01:57:28,000
COVID WAS 19%, BUT OF THOSE

2919
01:57:28,000 --> 01:57:31,560
ABOUT 40% REPORTED AT LEAST

2920
01:57:31,560 --> 01:57:34,760
HAVING ONE SYMPTOM, 12 WEEKS,

2921
01:57:34,760 --> 01:57:37,960
LASTING 12 WEEKS OR MORE AFTER

2922
01:57:37,960 --> 01:57:39,800
INFECTION, WHICH IS QUITE HIGH.

2923
01:57:39,800 --> 01:57:43,400
AND THEY IDENTIFIED IN THIS

2924
01:57:43,400 --> 01:57:47,000
STUDY TWO DISTINCT CLUSTERS,

2925
01:57:47,000 --> 01:57:48,200
TIREDNESS CLUSTER, WHERE

2926
01:57:48,200 --> 01:57:49,640
TIREDNESS CO-OCCURRED WITH

2927
01:57:49,640 --> 01:57:50,680
MUSCLE ACHES AND DIFFICULTY

2928
01:57:50,680 --> 01:57:56,720
SLEEPING AND SHORTNESS OF BREATH

2929
01:57:56,720 --> 01:57:58,280
AND RESPIRATORY THAT INCLUDED

2930
01:57:58,280 --> 01:58:01,640
SHORTNESS OF BREATH BUT

2931
01:58:01,640 --> 01:58:03,120
TIGHTNESS OF THE CHEST AND CHEST

2932
01:58:03,120 --> 01:58:04,840
PAIN, AND UNDERSTANDING HOW

2933
01:58:04,840 --> 01:58:05,680
CLUSTERS, MAYBE PHENOTYPES ARE

2934
01:58:05,680 --> 01:58:08,440
REALLY GOING TO BE HELPFUL IN

2935
01:58:08,440 --> 01:58:11,160
UNDERSTANDING PASC AND HOW TO

2936
01:58:11,160 --> 01:58:14,000
TARGET THE TREATMENTS.

2937
01:58:14,000 --> 01:58:15,800
YOU CAN SEE HERE SORT OF GETTING

2938
01:58:15,800 --> 01:58:17,040
BACK AMOUNT WHAT I MENTIONED

2939
01:58:17,040 --> 01:58:19,040
EARLIER A HIGHER PERCENTAGE OF

2940
01:58:19,040 --> 01:58:24,160
PEOPLE IN THE RESPIRATORY

2941
01:58:24,160 --> 01:58:25,600
CLUSTER REPORTED SEVERE CLUSTERS

2942
01:58:25,600 --> 01:58:27,440
THAN TIREDNESS BUT THAT MAY HAVE

2943
01:58:27,440 --> 01:58:31,520
TO DO WITH SEVERITY OF THE 

2944
01:58:31,520 --> 01:58:33,680
ILLNESS THAT THEY HAD.

2945
01:58:33,680 --> 01:58:35,240
SOME GREAT AND VERY IMPORTANT

2946
01:58:35,240 --> 01:58:38,480
DATA HAVE COME OUT OF THE U.S.

2947
01:58:38,480 --> 01:58:41,760
DEPARTMENT OF VETERANS AFFAIRS

2948
01:58:41,760 --> 01:58:43,440
HEALTH DATABASE, WHERE PEOPLE

2949
01:58:43,440 --> 01:58:46,000
HAVE BEEN -- THEY HAVE HAD

2950
01:58:46,000 --> 01:58:48,040
75,000 PEOPLE THAT THEY HAVE

2951
01:58:48,040 --> 01:58:49,440
IDENTIFIED WITH A COVID

2952
01:58:49,440 --> 01:58:52,920
DIAGNOSIS, AND THEY WERE ABLE TO

2953
01:58:52,920 --> 01:58:53,840
COMPARE THAT TO ROUGHLY 5

2954
01:58:53,840 --> 01:58:55,640
MILLION PEOPLE WHO USE THE

2955
01:58:55,640 --> 01:58:58,840
HEALTH CARE SYSTEM AND WERE

2956
01:58:58,840 --> 01:59:00,360
FOUND -- NOT FOUND TO HAVE A

2957
01:59:00,360 --> 01:59:02,320
COVID INFECTION DURING THE STUDY

2958
01:59:02,320 --> 01:59:02,560
PERIOD.

2959
01:59:02,560 --> 01:59:05,480
BEYOND THE FIRST 30 DAYS, PEOPLE

2960
01:59:05,480 --> 01:59:08,240
WITH COVID-19 DID HAVE A GREATER

2961
01:59:08,240 --> 01:59:11,280
RISK OF DEATH AND USE OF HEALTH

2962
01:59:11,280 --> 01:59:12,120
CARE RESOURCES, MEANING THAT

2963
01:59:12,120 --> 01:59:15,360
PEOPLE ARE AT RISK OF DEATH EVEN

2964
01:59:15,360 --> 01:59:16,840
BEYOND THAT, YOU KNOW, EARLY

2965
01:59:16,840 --> 01:59:17,480
INFECTION STAGE.

2966
01:59:17,480 --> 01:59:19,120
SO THIS IS SOMETHING THAT REALLY

2967
01:59:19,120 --> 01:59:21,840
NEEDS TO BE DELVED INTO FURTHER.

2968
01:59:21,840 --> 01:59:26,360
AND THERE WERE MANY DIFFERENT

2969
01:59:26,360 --> 01:59:29,960
SYSTEMS INVOLVED, INCLUDING

2970
01:59:29,960 --> 01:59:31,480
RESPIRATORY, NERVOUS SYSTEM

2971
01:59:31,480 --> 01:59:34,440
INCLUDED NEUROCOGNITIVE 

2972
01:59:34,440 --> 01:59:35,960
DISORDERS AND MENTAL HEALTH,

2973
01:59:35,960 --> 01:59:38,680
OTHER SYSTEMS AS WELL, ALSO AN

2974
01:59:38,680 --> 01:59:42,000
INCIDENT USE OF MANY DIFFERENT

2975
01:59:42,000 --> 01:59:48,640
MEDICATION TYPES, INCLUDING PAIN

2976
01:59:48,640 --> 01:59:49,600
MEDICATIONS, ANTI-DEPRESSIVE,

2977
01:59:49,600 --> 01:59:50,240
ANXIOLYTIC, ORAL HYPOGLYCEMICS

2978
01:59:50,240 --> 01:59:51,160
AS I REFERRED TO AT THE

2979
01:59:51,160 --> 01:59:53,440
BEGINNING OF THE TALK, THERE'S

2980
01:59:53,440 --> 01:59:56,520
AN INTEREST IN HOW SARS-COV-2

2981
01:59:56,520 --> 01:59:59,160
MAY ACTUALLY CREATE A RISK FOR

2982
01:59:59,160 --> 02:00:01,120
DEVELOPING SOME OTHER RISK

2983
02:00:01,120 --> 02:00:04,480
FACTORS FOR WELL KNOWN DISEASES.

2984
02:00:04,480 --> 02:00:06,800
SO IT SEEMS THERE'S A RISK

2985
02:00:06,800 --> 02:00:08,120
GRADIENT ACCORDING TO THE

2986
02:00:08,120 --> 02:00:11,680
SEVERITY THAT WE REALLY NEED TO

2987
02:00:11,680 --> 02:00:12,440
FURTHER UNDERSTAND.

2988
02:00:12,440 --> 02:00:15,480
BUT NOW WE ARE IN A SITUATION

2989
02:00:15,480 --> 02:00:18,760
WHERE MANY PEOPLE ARE BECOMING

2990
02:00:18,760 --> 02:00:20,520
VACCINATED, WE HOPE.

2991
02:00:20,520 --> 02:00:22,360
AND THERE ARE PEOPLE THAT HAVE

2992
02:00:22,360 --> 02:00:24,320
BEEN VACCINATED, PEOPLE THAT

2993
02:00:24,320 --> 02:00:26,760
HAVE BEEN BOOSTED, AND SO THE

2994
02:00:26,760 --> 02:00:29,880
QUESTION IS HOW DOES THAT RELATE

2995
02:00:29,880 --> 02:00:31,640
TO PASC?

2996
02:00:31,640 --> 02:00:33,840
AND THIS ONE STUDY HERE FOUND

2997
02:00:33,840 --> 02:00:36,360
THAT FULLY VACCINATED PEOPLE WHO

2998
02:00:36,360 --> 02:00:36,920
DEVELOPED BREAKTHROUGH

2999
02:00:36,920 --> 02:00:38,880
INFECTIONS WERE ABOUT HALF AS

3000
02:00:38,880 --> 02:00:41,840
LIKELY AS UNVACCINATED PEOPLE TO

3001
02:00:41,840 --> 02:00:43,280
REPORT SYMPTOMS OF LONG COVID

3002
02:00:43,280 --> 02:00:48,720
THAT LASTED AT LEAST FOUR WEEKS

3003
02:00:48,720 --> 02:00:50,040
AFTER INFECTION.

3004
02:00:50,040 --> 02:00:52,800
AND THE DEPARTMENT OF VETERANS

3005
02:00:52,800 --> 02:00:54,960
AFFAIRS DATABASE HAS ALSO

3006
02:00:54,960 --> 02:00:58,560
YIELDED SOME IMPORTANT RESULTS

3007
02:00:58,560 --> 02:01:01,320
HERE AS WELL, WHERE IT FOUND, A

3008
02:01:01,320 --> 02:01:04,680
STUDY FROM HERE FOUND THAT

3009
02:01:04,680 --> 02:01:06,440
PEOPLE WITH COVID-19 AND

3010
02:01:06,440 --> 02:01:08,440
BREAKTHROUGH HAD A GREATER RISK

3011
02:01:08,440 --> 02:01:11,720
OF DEATH AND BROAD ARRAY OF

3012
02:01:11,720 --> 02:01:13,240
POST-ACUTE SEQUELAE BEYOND THE

3013
02:01:13,240 --> 02:01:15,160
FIRST 30 DAYS, COMPARED TO

3014
02:01:15,160 --> 02:01:18,080
PEOPLE WITH NO EVIDENCE OF

3015
02:01:18,080 --> 02:01:19,640
COVID-19, BUT A LOWER RISK

3016
02:01:19,640 --> 02:01:22,440
COMPARED TO PEOPLE WHO ARE

3017
02:01:22,440 --> 02:01:24,840
UNVACCINATED, AND YOU COULD SEE

3018
02:01:24,840 --> 02:01:27,600
THAT ALSO SEEMS TO DIFFER BY

3019
02:01:27,600 --> 02:01:28,960
HOSPITALIZATION STATUS, WHICH IS

3020
02:01:28,960 --> 02:01:33,840
WHAT IS SHOWN IN THE PANEL ON

3021
02:01:33,840 --> 02:01:36,560
THE RIGHT SIDE.

3022
02:01:36,560 --> 02:01:42,400
SO WE REALLY NEED MORE ROBUST

3023
02:01:42,400 --> 02:01:43,080
DATA, EPIDEMIOLOGIC DATA.

3024
02:01:43,080 --> 02:01:46,280
WE THINK IT'S VERY IMPORTANT TO

3025
02:01:46,280 --> 02:01:47,920
UNDERSTAND PHENOTYPES AND

3026
02:01:47,920 --> 02:01:49,120
CLINICAL SPECTRUM OF PASC IN

3027
02:01:49,120 --> 02:01:52,200
ORDER TO BE ABLE TO APPROACH IT

3028
02:01:52,200 --> 02:01:53,600
PROPERLY.

3029
02:01:53,600 --> 02:01:56,040
WE NEED TO UNDERSTAND THE

3030
02:01:56,040 --> 02:01:58,760
DURATION OF PASC, THOSE OF YOU

3031
02:01:58,760 --> 02:02:02,040
WHO REMEMBER THE -- WELL, YOU

3032
02:02:02,040 --> 02:02:03,400
WOULDN'T REMEMBER THE INFLUENZA

3033
02:02:03,400 --> 02:02:04,440
PANDEMIC FROM A HUNDRED YEARS

3034
02:02:04,440 --> 02:02:07,200
AGO BUT YOU REMEMBER READING

3035
02:02:07,200 --> 02:02:07,640
ABOUT IT.

3036
02:02:07,640 --> 02:02:10,680
AND YOU REMEMBER THAT TEN YEARS

3037
02:02:10,680 --> 02:02:13,120
LATER PEOPLE DEVELOPED -- SOME

3038
02:02:13,120 --> 02:02:14,160
PEOPLE DEVELOPED PARKINSON'S,

3039
02:02:14,160 --> 02:02:14,520
RIGHT?

3040
02:02:14,520 --> 02:02:17,200
SO, HOW LONG DOES IT TAKE FOR

3041
02:02:17,200 --> 02:02:19,160
SOME OF THESE SYMPTOMS TO SHOW

3042
02:02:19,160 --> 02:02:20,680
UP AND SIGNS TO SHOW UP?

3043
02:02:20,680 --> 02:02:22,840
THIS NEEDS TO REALLY BE

3044
02:02:22,840 --> 02:02:23,320
UNDERSTOOD.

3045
02:02:23,320 --> 02:02:25,840
WHAT ARE THE RISK FACTORS FOR

3046
02:02:25,840 --> 02:02:27,560
THE DEVELOPMENT OF PASC?

3047
02:02:27,560 --> 02:02:29,640
THE IMPACT OF VACCINATION,

3048
02:02:29,640 --> 02:02:31,680
EFFECT OF DIFFERENT VARIANTS,

3049
02:02:31,680 --> 02:02:33,080
NOW WE ARE OF COURSE HOPEFULLY

3050
02:02:33,080 --> 02:02:35,320
ON THE TAIL END IN SOME PLACES

3051
02:02:35,320 --> 02:02:37,200
OF OMICRON, OF COURSE IN OTHER

3052
02:02:37,200 --> 02:02:38,480
PLACES WE'RE NOT.

3053
02:02:38,480 --> 02:02:41,840
WE NEED TO UNDERSTAND GIVEN THAT

3054
02:02:41,840 --> 02:02:43,920
OMICRON BEHAVES DIFFERENTLY THAN

3055
02:02:43,920 --> 02:02:44,960
DELTA DID, FOR EXAMPLE, DOES

3056
02:02:44,960 --> 02:02:51,040
THAT HAVE AN EFFECT ON HOW THE

3057
02:02:51,040 --> 02:02:53,880
TYPES OF SYMPTOMS DEVELOPED POST

3058
02:02:53,880 --> 02:02:54,520
INFECTION AND SYNDROMES,

3059
02:02:54,520 --> 02:02:56,440
PHENOTYPES, IF YOU WILL.

3060
02:02:56,440 --> 02:02:58,040
WHAT IS THE UNDERLYING

3061
02:02:58,040 --> 02:02:59,200
PATHOBIOLOGY?

3062
02:02:59,200 --> 02:03:02,200
AND THEN OF COURSE IDENTIFYING

3063
02:03:02,200 --> 02:03:02,840
THERAPEUTIC TARGETS.

3064
02:03:02,840 --> 02:03:06,400
SO, WHAT DO WE KNOW ABOUT THE

3065
02:03:06,400 --> 02:03:06,840
CAUSES?

3066
02:03:06,840 --> 02:03:09,440
WELL, IT'S VERY MUCH AN EARLY

3067
02:03:09,440 --> 02:03:13,160
STAGE IN UNDERSTANDING THIS.

3068
02:03:13,160 --> 02:03:16,280
BUT THERE'S CERTAINLY CERTAIN

3069
02:03:16,280 --> 02:03:18,040
TISSUES THAT SEEM TO

3070
02:03:18,040 --> 02:03:20,400
STIMULATE -- THAT HAVE ONGOING

3071
02:03:20,400 --> 02:03:21,760
DYSFUNCTIONAL IMMUNE RESPONSES

3072
02:03:21,760 --> 02:03:24,400
AND TISSUE DAMAGE.

3073
02:03:24,400 --> 02:03:26,600
DYSREGULATED IMMUNE REACTIONS

3074
02:03:26,600 --> 02:03:28,560
THAT RESULT IN INFLAMMATION,

3075
02:03:28,560 --> 02:03:30,720
THAT MAY ALSO BE INVOLVED.

3076
02:03:30,720 --> 02:03:32,280
THERE'S EVIDENCE OF ABNORMAL

3077
02:03:32,280 --> 02:03:34,560
PROFILES IN IMMUNE CELLS AND

3078
02:03:34,560 --> 02:03:36,040
INFLAMMATORY MOLECULES THAT NEED

3079
02:03:36,040 --> 02:03:37,840
TO BE FURTHER UNDERSTOOD.

3080
02:03:37,840 --> 02:03:42,040
AND THEN THERE'S THE ASPECT OF

3081
02:03:42,040 --> 02:03:43,440
AUTOIMMUNITY, PERSISTENCE OF

3082
02:03:43,440 --> 02:03:44,200
VIRAL PARTICLES, VIRAL

3083
02:03:44,200 --> 02:03:48,240
INFECTION, THAT MAY SET UP AN

3084
02:03:48,240 --> 02:03:50,200
AUTOIMMUNE REACTION.

3085
02:03:50,200 --> 02:03:53,240
AND THEN THE DAMAGE TO SPECIFIC

3086
02:03:53,240 --> 02:03:55,040
ORGANS AND TISSUES THAT RESULT

3087
02:03:55,040 --> 02:03:58,840
IN DIFFERENT SYSTEMS BEING

3088
02:03:58,840 --> 02:03:59,200
DYSFUNCTIONAL.

3089
02:03:59,200 --> 02:04:02,040
THAT'S VERY DIFFICULT AND VERY

3090
02:04:02,040 --> 02:04:04,960
CHALLENGING TO STUDY IN PATIENTS

3091
02:04:04,960 --> 02:04:07,480
BECAUSE IT'S HARD TO SEPARATE

3092
02:04:07,480 --> 02:04:09,880
THE WHEAT FROM THE CHAFF IN

3093
02:04:09,880 --> 02:04:12,440
TERMS OF WHAT HAPPENED WHEN THEY

3094
02:04:12,440 --> 02:04:14,840
HAD ACUTE ILLNESS VERSUS LATER

3095
02:04:14,840 --> 02:04:15,280
EFFECTS.

3096
02:04:15,280 --> 02:04:17,640
SO WE HAVE THIS POTPOURRI OF

3097
02:04:17,640 --> 02:04:19,720
SYMPTOMS THAT YOU SEE HERE ON

3098
02:04:19,720 --> 02:04:23,040
THE LEFT, AND MANY DIFFERENT

3099
02:04:23,040 --> 02:04:24,360
ORGAN SYSTEMS, AND CONDITIONS,

3100
02:04:24,360 --> 02:04:27,040
INVOLVED ON THE RIGHT.

3101
02:04:27,040 --> 02:04:29,840
SORT OF SEPARATING THESE OUT AND

3102
02:04:29,840 --> 02:04:30,840
THEN UNDERSTANDING, YOU KNOW,

3103
02:04:30,840 --> 02:04:33,200
HOW THEY RELATE TO EACH OTHER

3104
02:04:33,200 --> 02:04:35,800
REALLY REQUIRES A VERY

3105
02:04:35,800 --> 02:04:36,280
MULTI-PRONGED APPROACH,

3106
02:04:36,280 --> 02:04:39,960
ESPECIALLY IF WE'RE GOING TO 

3107
02:04:39,960 --> 02:04:40,840
HOPE TO DEVELOP TREATMENTS.

3108
02:04:40,840 --> 02:04:45,040
SO IN TERMS OF POTENTIAL

3109
02:04:45,040 --> 02:04:47,280
TREATMENTS, RIGHT NOW THERE ARE

3110
02:04:47,280 --> 02:04:50,360
THREE MAIN AREAS.

3111
02:04:50,360 --> 02:04:52,640
THE IDEA OF PERSISTENT

3112
02:04:52,640 --> 02:04:55,920
SARS-COV-2 VIRUS THAT WOULD BE

3113
02:04:55,920 --> 02:04:59,040
AMENABLE TO ANTI-VIRALS, THE

3114
02:04:59,040 --> 02:04:59,640
POTENTIAL FOR DYSREGULATED

3115
02:04:59,640 --> 02:05:02,400
IMMUNE RESPONSE TO RESPOND TO

3116
02:05:02,400 --> 02:05:05,880
IMMUNE MODULATORS, AND THEN SOME

3117
02:05:05,880 --> 02:05:07,080
VERY ORGAN AND TISSUE-SPECIFIC

3118
02:05:07,080 --> 02:05:10,360
INTERVENTIONS THAT MAY EITHER BE

3119
02:05:10,360 --> 02:05:11,160
MEDICATIONS OR

3120
02:05:11,160 --> 02:05:11,600
NON-PHARMACOLOGICAL

3121
02:05:11,600 --> 02:05:14,440
INTERVENTIONS THAT COULD HELP

3122
02:05:14,440 --> 02:05:17,440
WITH TARGETING SPECIFIC AREAS, 

3123
02:05:17,440 --> 02:05:18,720
LUNG, HEART, BLOOD VESSELS.

3124
02:05:18,720 --> 02:05:22,240
THERE ARE A NUMBER OF

3125
02:05:22,240 --> 02:05:23,000
NEUROCOGNITIVE AND OTHER

3126
02:05:23,000 --> 02:05:24,520
REHABILITATIVE STRATEGIES THAT

3127
02:05:24,520 --> 02:05:27,080
MAY BE HELPFUL, AND COGNITIVE

3128
02:05:27,080 --> 02:05:28,080
BEHAVIORAL THERAPIES, AND ON AND

3129
02:05:28,080 --> 02:05:28,440
ON.

3130
02:05:28,440 --> 02:05:30,320
SO ALL OF THESE THINGS NEED TO

3131
02:05:30,320 --> 02:05:32,960
BE PUT IN THE PERSPECTIVE AS WE

3132
02:05:32,960 --> 02:05:34,120
GAIN MORE INFORMATION.

3133
02:05:34,120 --> 02:05:36,120
BUT I THINK THE TAKEHOME MESSAGE

3134
02:05:36,120 --> 02:05:39,680
FROM ALL OF THIS IS THAT WE

3135
02:05:39,680 --> 02:05:40,960
REALLY NEED TO CHARACTERIZE

3136
02:05:40,960 --> 02:05:42,840
WHAT'S GOING ON FIRST BEFORE WE

3137
02:05:42,840 --> 02:05:47,160
CAN REALLY HOPE TO TREAT IT.

3138
02:05:47,160 --> 02:05:49,880
SO THE NIH RECOVER INITIATIVE,

3139
02:05:49,880 --> 02:05:58,080
THE MAIN GOAL BEING TO RAPIDLY

3140
02:05:58,080 --> 02:05:58,960
IMPROVE UNDERSTANDING, HAS KEY

3141
02:05:58,960 --> 02:06:00,400
SCIENTIFIC AIMS HERE, MOST OF

3142
02:06:00,400 --> 02:06:05,640
WHICH I HAVE ALREADY KIND  OF

3143
02:06:05,640 --> 02:06:06,360
RUN THROUGH.

3144
02:06:06,360 --> 02:06:10,440
I WANT TO EMPHASIZE THE GUIDING

3145
02:06:10,440 --> 02:06:12,160
PRINCIPLE OF THIS EFFORT HAS

3146
02:06:12,160 --> 02:06:12,960
BEEN TO CREATE A

3147
02:06:12,960 --> 02:06:14,240
PATIENT-CENTERED APPROACH BUT

3148
02:06:14,240 --> 02:06:17,360
THIS HAS A NATIONAL SCALE.

3149
02:06:17,360 --> 02:06:18,360
IT'S VERY MULTI-DISCIPLINARY, AS

3150
02:06:18,360 --> 02:06:19,480
I ALREADY MENTIONED.

3151
02:06:19,480 --> 02:06:22,320
IT HAS TO BE ADAPTIVE BECAUSE,

3152
02:06:22,320 --> 02:06:25,480
YOU KNOW, NOW WE'RE IN OMICRON,

3153
02:06:25,480 --> 02:06:27,440
HOPEFULLY THERE WON'T BE ANOTHER

3154
02:06:27,440 --> 02:06:30,520
VARIANT, BUT THERE ARE WAVES AND

3155
02:06:30,520 --> 02:06:34,120
WAVES OF THESE VARIANTS THAT

3156
02:06:34,120 --> 02:06:35,320
HAVE CAUSED MAYBE DIFFERENT

3157
02:06:35,320 --> 02:06:37,240
SEQUELAE THAT WE DON'T EVEN KNOW

3158
02:06:37,240 --> 02:06:38,400
ABOUT.

3159
02:06:38,400 --> 02:06:39,840
THERE ARE A NUMBER OF

3160
02:06:39,840 --> 02:06:41,880
STAKEHOLDERS THAT I'VE LISTED

3161
02:06:41,880 --> 02:06:44,320
HERE, ON THE RIGHT-HAND SIDE,

3162
02:06:44,320 --> 02:06:48,240
THAT ARE WORKING TOGETHER AND

3163
02:06:48,240 --> 02:06:48,840
COLLABORATING.

3164
02:06:48,840 --> 02:06:50,800
AND SO THE RECOVER CORES

3165
02:06:50,800 --> 02:06:54,640
INCLUDE A SCIENCE CORE, DATA

3166
02:06:54,640 --> 02:06:56,160
CORE, BIOREPOSITORY THAT SUPPORT

3167
02:06:56,160 --> 02:06:59,080
THE DIFFERENT STUDIES. 

3168
02:06:59,080 --> 02:07:01,600
THE THREE MAIN STUDIES ARE

3169
02:07:01,600 --> 02:07:02,920
RECOVER SET OF COHORTS THAT ARE

3170
02:07:02,920 --> 02:07:04,040
GOING TO ACTUALLY ENROLL PEOPLE,

3171
02:07:04,040 --> 02:07:05,440
I'LL TELL YOU A LITTLE BIT THAT

3172
02:07:05,440 --> 02:07:08,600
IN A SECONDS.

3173
02:07:08,600 --> 02:07:12,240
A VERY ROBUST ELECTRONIC HEALTH

3174
02:07:12,240 --> 02:07:14,720
RECORD SYSTEM METHOD THAT WILL

3175
02:07:14,720 --> 02:07:18,200
INCLUDE 40 MILLION RECORDS AND

3176
02:07:18,200 --> 02:07:24,760
ABOUT 4 MILLION CASES PLUMBED

3177
02:07:24,760 --> 02:07:26,040
AND ALWAYS-BASED STUDY TO LOOK

3178
02:07:26,040 --> 02:07:29,560
AT MORE THAN 50 TISSUE TYPES.

3179
02:07:29,560 --> 02:07:33,160
AND THERE ARE MANY RESOURCES

3180
02:07:33,160 --> 02:07:35,680
THAT SUPPORT THIS.

3181
02:07:35,680 --> 02:07:38,520
 

3182
02:07:38,520 --> 02:07:41,360
AND SO IN TERMS OF THE COHORTS,

3183
02:07:41,360 --> 02:07:42,360
THERE'S AN ACUTE INFECTION

3184
02:07:42,360 --> 02:07:44,520
COHORT WHERE WE HAVE THE

3185
02:07:44,520 --> 02:07:46,280
OPPORTUNITY TO BRING PEOPLE IN

3186
02:07:46,280 --> 02:07:48,600
AND FOLLOW THEM, AND SEE WHO

3187
02:07:48,600 --> 02:07:49,360
DEVELOPS PASC.

3188
02:07:49,360 --> 02:07:51,840
WE ALSO HAVE A POST-ACUTE

3189
02:07:51,840 --> 02:07:53,160
INFECTION COHORT WHERE PEOPLE

3190
02:07:53,160 --> 02:07:55,240
HAVE ALREADY BEEN INFECTED, WE

3191
02:07:55,240 --> 02:07:56,320
CAN TEST THEM FOR DIFFERENT

3192
02:07:56,320 --> 02:08:00,160
ANTIBODIES AND FIND OUT IF THEY

3193
02:08:00,160 --> 02:08:11,640
WERE INFECTED, AND THEN RETRO 

3194
02:08:11,640 --> 02:08:13,280
S PECTIVE STUDIES, ABILITY TO

3195
02:08:13,280 --> 02:08:14,560
STUDY PREGNANT WOMEN, AND

3196
02:08:14,560 --> 02:08:16,120
CHILDREN, IN THE COHORTS,

3197
02:08:16,120 --> 02:08:19,240
INCLUDING 40,000 PEOPLE FROM 200

3198
02:08:19,240 --> 02:08:24,040
SITES ACROSS ALL 50 STATES.  AND

3199
02:08:24,040 --> 02:08:27,440
THEN THE PEOPLE THAT ARE IN THE

3200
02:08:27,440 --> 02:08:29,080
COHORT STUDIES WILL BE SCREENED

3201
02:08:29,080 --> 02:08:32,360
AND THEY WILL UNDERGO WHAT WE

3202
02:08:32,360 --> 02:08:34,440
CALL THE TIER 1 LEVEL

3203
02:08:34,440 --> 02:08:36,320
ASSESSMENTS THAT WILL INCLUDE

3204
02:08:36,320 --> 02:08:38,440
MANY QUESTIONNAIRES AND CLINICAL

3205
02:08:38,440 --> 02:08:38,960
ASSESSMENTS AND SOCIAL

3206
02:08:38,960 --> 02:08:41,680
DETERMINANTS OF HEALTH AND

3207
02:08:41,680 --> 02:08:43,000
PSYCHOSOCIAL FACTORS, AND THEN

3208
02:08:43,000 --> 02:08:46,680
DEPENDING ON HOW THEY RESPOND TO

3209
02:08:46,680 --> 02:08:48,200
THOSE QUESTIONNAIRES AND

3210
02:08:48,200 --> 02:08:49,400
INSTRUMENTS, A RANDOM SAMPLE

3211
02:08:49,400 --> 02:08:53,040
WILL BE SELECTED TO UNDERGO TIER

3212
02:08:53,040 --> 02:08:55,040
2, SO 40,000 PEOPLE AS I

3213
02:08:55,040 --> 02:08:56,440
MENTIONED ALREADY IN TIER 1,

3214
02:08:56,440 --> 02:08:58,840
ABOUT 10,000 IN TIER 2, AND

3215
02:08:58,840 --> 02:09:03,000
ABOUT 5,000 WILL GO EVEN DEEPER,

3216
02:09:03,000 --> 02:09:03,640
UNDERGO EVEN DEEPER PHENOTYPING,

3217
02:09:03,640 --> 02:09:05,720
THAT YOU CAN SEE LISTED HERE

3218
02:09:05,720 --> 02:09:09,440
INCLUDING DEEP IMAGING AND SO

3219
02:09:09,440 --> 02:09:09,880
ON.

3220
02:09:09,880 --> 02:09:12,400
ONE OF THE MOST IMPORTANT THINGS

3221
02:09:12,400 --> 02:09:17,840
ABOUT COVID THAT HAS BEEN VERY

3222
02:09:17,840 --> 02:09:20,880
INSTRUCTIVE HAS BEEN THE

3223
02:09:20,880 --> 02:09:23,000
DISPARITIES IN COVID AND THE

3224
02:09:23,000 --> 02:09:24,520
DISPARITIES IN PASC.

3225
02:09:24,520 --> 02:09:27,360
AND SO WHEN RECOVER WAS

3226
02:09:27,360 --> 02:09:29,440
DESIGNED, THE IDEA WAS TO TARGET

3227
02:09:29,440 --> 02:09:33,160
THE POPULATIONS THAT WERE MOST

3228
02:09:33,160 --> 02:09:34,000
AFFECTED BY COVID, RATHER THAN

3229
02:09:34,000 --> 02:09:36,040
SIMPLY REPRESENT THE U.S.

3230
02:09:36,040 --> 02:09:36,320
POPULATION.

3231
02:09:36,320 --> 02:09:40,600
SO YOU CAN SEE THE TARGET

3232
02:09:40,600 --> 02:09:41,920
ENROLLMENT FOR THE DIFFERENT --

3233
02:09:41,920 --> 02:09:44,040
SOME DIFFERENT RACIAL AND ETHNIC

3234
02:09:44,040 --> 02:09:45,840
GROUPS HERE, THEY ARE SOMEWHAT

3235
02:09:45,840 --> 02:09:50,880
OVERSAMPLED IN ORDER TO TRY AND

3236
02:09:50,880 --> 02:09:52,120
ACCOMPLISH THAT.

3237
02:09:52,120 --> 02:09:55,640
SO IN TERMS OF WHAT NIA MAY BE

3238
02:09:55,640 --> 02:09:58,440
INTERESTED IN, I CREATED A FEW

3239
02:09:58,440 --> 02:10:00,000
SLIDES JUST LOOKING A LITTLE

3240
02:10:00,000 --> 02:10:01,640
DEEPER AT THE TIER LEVEL

3241
02:10:01,640 --> 02:10:04,040
ASSESSMENTS THAT MAY BE

3242
02:10:04,040 --> 02:10:06,080
SPECIFICALLY RELEVANT TO NIA, SO

3243
02:10:06,080 --> 02:10:11,800
YOU CAN SEE THE DISABILITY

3244
02:10:11,800 --> 02:10:15,040
SCREENS, COMORBIDITY, PHYSICAL

3245
02:10:15,040 --> 02:10:16,000
FUNCTION ASSESSMENTS, LABORATORY

3246
02:10:16,000 --> 02:10:19,400
TESTS DONE IN DIFFERENT TIERS

3247
02:10:19,400 --> 02:10:21,760
COLOR CODED TO TIER 1, TIER 2,

3248
02:10:21,760 --> 02:10:24,320
TIER 3 ON THE BOTTOM OF THE

3249
02:10:24,320 --> 02:10:25,240
SLIDE.

3250
02:10:25,240 --> 02:10:26,080
NEUROFILAMENT LIGHT AND TAU, FOR

3251
02:10:26,080 --> 02:10:30,120
EXAMPLE, WILL BE IN TIER 3, THAT

3252
02:10:30,120 --> 02:10:32,320
THE SIX-MINUTE WALK TEST, GRIP

3253
02:10:32,320 --> 02:10:33,720
STRENGTH, QUADRICEP STRENGTH AND

3254
02:10:33,720 --> 02:10:36,680
TIMED UP AND GO WILL BE IN TIER

3255
02:10:36,680 --> 02:10:37,120
2.

3256
02:10:37,120 --> 02:10:39,760
AND THEN ON THIS SLIDE YOU CAN

3257
02:10:39,760 --> 02:10:49,160
SEE THAT MRI AND LUMBAR PUNCTURE

3258
02:10:49,160 --> 02:10:51,400
TIER 3 IN-DEPTH TESTING, OTHER

3259
02:10:51,400 --> 02:10:52,560
NEUROPSYCH TESTING AS PART OF

3260
02:10:52,560 --> 02:10:53,200
TIER 2.

3261
02:10:53,200 --> 02:10:55,160
SOME OF THESE ARE INTERESTING, I

3262
02:10:55,160 --> 02:11:00,440
THINK, IN TERMS OF AGING AND

3263
02:11:00,440 --> 02:11:00,960
ADRDs.

3264
02:11:00,960 --> 02:11:03,680
I WANTED TO MENTION ALSO THAT

3265
02:11:03,680 --> 02:11:06,640
THE AUTOPSY COHORT WILL INCLUDE

3266
02:11:06,640 --> 02:11:08,040
COMPREHENSIVE EXAM OF THE

3267
02:11:08,040 --> 02:11:14,360
CENTRAL NERVOUS SYSTEM, AS WELL

3268
02:11:14,360 --> 02:11:29,240
AS SPECIFIC SAMPLING,

3269
02:11:29,240 --> 02:11:30,280
POSTMORTEMCS BRAIN MRI.

3270
02:11:30,280 --> 02:11:32,440
THIS IS MORE OPEN FOR YOUR

3271
02:11:32,440 --> 02:11:32,760
DISCUSSION.

3272
02:11:32,760 --> 02:11:33,680
WHAT IS THE PREVALENCE AND

3273
02:11:33,680 --> 02:11:36,720
INCIDENCE OF PASC IN AGING

3274
02:11:36,720 --> 02:11:38,160
POPULATIONS COMPARED WITH

3275
02:11:38,160 --> 02:11:39,200
YOUNGER ADULTS?

3276
02:11:39,200 --> 02:11:41,920
WHAT DIFFERS BY AGE, THE

3277
02:11:41,920 --> 02:11:43,320
CLINICAL COURSE, THE

3278
02:11:43,320 --> 02:11:45,000
SUBPHENOTYPES, UNDERLYING

3279
02:11:45,000 --> 02:11:45,640
MECHANISMS.

3280
02:11:45,640 --> 02:11:46,840
AND DOES THE PATHOPHYSIOLOGY OF

3281
02:11:46,840 --> 02:11:49,800
COVID AND/OR PASC DIFFER BY AGE

3282
02:11:49,800 --> 02:11:54,840
AT INFECTION OR AGE AT DEATH.

3283
02:11:54,840 --> 02:11:56,560
AND UNDERSTANDING THE PASC

3284
02:11:56,560 --> 02:12:02,240
FEATURES THAT AFFECT AGING, THE

3285
02:12:02,240 --> 02:12:07,520
NEUROLOGICAL CONSEQUENCES,

3286
02:12:07,520 --> 02:12:08,480
COGNITIVE CONSEQUENCES,

3287
02:12:08,480 --> 02:12:10,800
VARIABILITY ACROSS SEQUELAE IN

3288
02:12:10,800 --> 02:12:14,120
POPULATION DEMOGRAPHICS, 

3289
02:12:14,120 --> 02:12:16,520
RELATIVE RELATIVE TO AGE, SEX,

3290
02:12:16,520 --> 02:12:17,240
ETHNICITY.

3291
02:12:17,240 --> 02:12:18,840
WE NEED TO UNDERSTAND

3292
02:12:18,840 --> 02:12:20,120
PHYSIOLOGIC AND ENVIRONMENTAL

3293
02:12:20,120 --> 02:12:24,640
AND BEHAVIORAL FACTORS THAT MAY

3294
02:12:24,640 --> 02:12:26,160
CONTRIBUTE TO THE SUSCEPTIBILITY

3295
02:12:26,160 --> 02:12:28,600
OF OLDER ADULTS TO SEQUELAE OF

3296
02:12:28,600 --> 02:12:30,320
SARS-COV-2 AND EFFECT OF

3297
02:12:30,320 --> 02:12:31,680
SYMPTOMS AND SEQUELAE ON

3298
02:12:31,680 --> 02:12:38,360
IMPORTANT OUTCOMES TO THE AGING

3299
02:12:38,360 --> 02:12:38,680
POPULATION.

3300
02:12:38,680 --> 02:12:40,040
AND THEN OTHER QUESTIONS HAVING

3301
02:12:40,040 --> 02:12:43,120
TO DO SPECIFICALLY WITH AD AND

3302
02:12:43,120 --> 02:12:45,640
ADRD ARE WHAT DOES SARS-COV-2

3303
02:12:45,640 --> 02:12:49,040
INFECTION AND/OR PASC HAVE TO DO

3304
02:12:49,040 --> 02:12:50,440
WITH PROGRESSION, DEVELOPMENT

3305
02:12:50,440 --> 02:12:54,160
AND PROGRESSION OF AD AND

3306
02:12:54,160 --> 02:12:56,880
ADRDs, AND WHAT DOES

3307
02:12:56,880 --> 02:12:59,880
UNDERLYING SUBCLINICAL OR EARLY

3308
02:12:59,880 --> 02:13:02,280
ADRDs, WHAT AFFECT DUGS THAT

3309
02:13:02,280 --> 02:13:04,240
HAVE ON THE COMORBIDITY OF THE

3310
02:13:04,240 --> 02:13:05,800
SARS-COV-2 AND HOW THAT PLAYS

3311
02:13:05,800 --> 02:13:07,040
OUT.

3312
02:13:07,040 --> 02:13:10,400
AND WHAT ARE INTERACTIONS AND

3313
02:13:10,400 --> 02:13:16,680
INCIDENTS AND PROGRESSION OF 

3314
02:13:16,680 --> 02:13:17,760
DIFFERENT OVERLAPPING MIXED

3315
02:13:17,760 --> 02:13:18,040
ETIOLOGIES.

3316
02:13:18,040 --> 02:13:20,400
SO THAT'S ALL I HAVE FOR YOU AT

3317
02:13:20,400 --> 02:13:21,160
THIS TIME.

3318
02:13:21,160 --> 02:13:22,800
I HOPE IT'S BEEN HELPFUL.

3319
02:13:22,800 --> 02:13:26,920
IT'S KIND OF A BROAD OVERVIEW.

3320
02:13:26,920 --> 02:13:29,680
IT GIVES YOU A PERSPECTIVE ON

3321
02:13:29,680 --> 02:13:31,160
WHERE RECOVER IS HEADED.

3322
02:13:31,160 --> 02:13:35,800
I WANTED TO JUST MENTION THAT

3323
02:13:35,800 --> 02:13:37,320
THE SENIOR OVERSIGHT COMMITTEE

3324
02:13:37,320 --> 02:13:42,320
IS LED BY DOCTORS FAUCI, GIBBONS

3325
02:13:42,320 --> 02:13:42,960
AND KOROSHETZ, AND I'M PREPARED

3326
02:13:42,960 --> 02:13:44,640
TO TAKE ANY QUESTIONS THAT YOU

3327
02:13:44,640 --> 02:13:47,080
MAY HAVE.

3328
02:13:47,080 --> 02:13:47,360
THANK YOU.

3329
02:13:47,360 --> 02:13:47,840
>> TERRIFIC.

3330
02:13:47,840 --> 02:13:51,800
THANK YOU VERY MUCH, DR. WRIGHT.

3331
02:13:51,800 --> 02:13:53,520
REALLY GREAT OVERVIEW OF THE

3332
02:13:53,520 --> 02:13:54,960
RECOVER INITIATIVE.

3333
02:13:54,960 --> 02:13:59,080
QUESTIONS FROM OUR COUNCIL

3334
02:13:59,080 --> 02:13:59,520
MEMBERS? 

3335
02:13:59,520 --> 02:13:59,800
YES, AMY?

3336
02:13:59,800 --> 02:14:01,400
>>  YEAH, THANK YOU VERY MUCH

3337
02:14:01,400 --> 02:14:04,080
FOR YOUR VERY CLEAR

3338
02:14:04,080 --> 02:14:04,440
PRESENTATION.

3339
02:14:04,440 --> 02:14:07,200
I WANTED TO ASK A QUESTION ABOUT

3340
02:14:07,200 --> 02:14:09,560
HOW UNIQUE PASC IS IN THE

3341
02:14:09,560 --> 02:14:10,200
CONTEXT OF OTHER RESPIRATORY

3342
02:14:10,200 --> 02:14:13,520
VIRUSES, AND IF THAT IS A

3343
02:14:13,520 --> 02:14:17,640
COMPONENT OF UNDERSTANDING THAT

3344
02:14:17,640 --> 02:14:22,000
THE RECOVER MISSION ENTAILS

3345
02:14:22,000 --> 02:14:22,240
INCLUDES.

3346
02:14:22,240 --> 02:14:22,680
>> GREAT QUESTION.

3347
02:14:22,680 --> 02:14:24,120
FROM THE STANDPOINT OF DATA OUT

3348
02:14:24,120 --> 02:14:28,440
THERE, IT DOES SEEM AS IF THAT

3349
02:14:28,440 --> 02:14:29,800
SARS-COV-2 HAS MORE SEVERE OR AT

3350
02:14:29,800 --> 02:14:31,760
LEAST THE EARLIER FORMS HAD A

3351
02:14:31,760 --> 02:14:34,560
MORE SEVERE SET OF OUTCOMES THAN

3352
02:14:34,560 --> 02:14:35,880
LET'S SAY INFLUENZA.

3353
02:14:35,880 --> 02:14:37,600
OF COURSE, THERE'S A LOT OF

3354
02:14:37,600 --> 02:14:39,320
DIFFERENT PATHOGENS OUT THERE,

3355
02:14:39,320 --> 02:14:41,280
AND SOME ARE RARER THAN OTHERS.

3356
02:14:41,280 --> 02:14:44,360
SO, IT'S A LOT EASIER TO STUDY

3357
02:14:44,360 --> 02:14:45,760
THE MORE PREVALENT SUCH AS

3358
02:14:45,760 --> 02:14:46,400
INFLUENZA.

3359
02:14:46,400 --> 02:14:48,840
NOW THAT WE'RE IN OMICRON

3360
02:14:48,840 --> 02:14:49,440
THOUGH, IT'S INTERESTING BECAUSE

3361
02:14:49,440 --> 02:14:53,320
IT'S A LITTLE BIT HARDER TO

3362
02:14:53,320 --> 02:14:54,440
PARSE THAT OUT BECAUSE MANY

3363
02:14:54,440 --> 02:14:56,040
TIMES LET'S SAY A COLD VIRUS

3364
02:14:56,040 --> 02:14:58,120
MIGHT NOT BE REPORTED AND IT'S

3365
02:14:58,120 --> 02:14:59,760
HARD TO REALLY STUDY THAT.

3366
02:14:59,760 --> 02:15:02,120
SO I THINK IT'S A REALLY

3367
02:15:02,120 --> 02:15:02,600
INTERESTING QUESTION.

3368
02:15:02,600 --> 02:15:06,320
ONE OF THE THINGS THAT'S REALLY

3369
02:15:06,320 --> 02:15:08,840
EXCITING ABOUT THE EHR DATA AND

3370
02:15:08,840 --> 02:15:10,800
REAL WORLD DATA, AND BY THE WAY,

3371
02:15:10,800 --> 02:15:13,840
YOU KNOW, I THINK IT'S BEEN A

3372
02:15:13,840 --> 02:15:14,920
TREMENDOUS OPPORTUNITY, YOU

3373
02:15:14,920 --> 02:15:19,080
KNOW, BECAUSE OF THE PANDEMIC TO

3374
02:15:19,080 --> 02:15:20,960
REALLY GET THIS HUGE DATA

3375
02:15:20,960 --> 02:15:22,640
TOGETHER, AND IT WILL I THINK

3376
02:15:22,640 --> 02:15:25,800
LIFT ALL BOATS IN TERMS OF

3377
02:15:25,800 --> 02:15:27,080
UNDERSTANDING MANY DIFFERENT

3378
02:15:27,080 --> 02:15:27,360
PROCESSES.

3379
02:15:27,360 --> 02:15:28,720
BUT BEING ABLE TO LOOK AT

3380
02:15:28,720 --> 02:15:29,800
MILLIONS AND MILLIONS OF RECORDS

3381
02:15:29,800 --> 02:15:31,320
WILL HELP US TO UNDERSTAND SOME

3382
02:15:31,320 --> 02:15:33,080
OF THOSE THINGS YOU JUST ASKED

3383
02:15:33,080 --> 02:15:35,120
ABOUT.

3384
02:15:35,120 --> 02:15:36,120
>> GREAT.

3385
02:15:36,120 --> 02:15:38,640
THANK YOU.

3386
02:15:38,640 --> 02:15:38,960
>> CLIFF?

3387
02:15:38,960 --> 02:15:40,880
>>  YEAH, HI.

3388
02:15:40,880 --> 02:15:41,200
CLIFF ROSEN.

3389
02:15:41,200 --> 02:15:50,680
I JUST FINISHED ON   COUNCIL.

3390
02:15:50,680 --> 02:15:53,320
THANK YOU FOR YOUR EFFORTS.

3391
02:15:53,320 --> 02:15:55,640
THIS IS A COMPLEX AND

3392
02:15:55,640 --> 02:15:56,040
MULTI-LAYER PROCESS.

3393
02:15:56,040 --> 02:15:58,480
I THINK THE NIH HAS DONE AN

3394
02:15:58,480 --> 02:16:00,320
AMAZING JOB WITH, QUOTE, THE

3395
02:16:00,320 --> 02:16:02,640
SYNDROME TRYING TO UNDERSTAND

3396
02:16:02,640 --> 02:16:06,200
HOW TO MEASURE IT AND ALSO

3397
02:16:06,200 --> 02:16:07,840
MOVING FORWARD THE PATHOBIOLOGY.

3398
02:16:07,840 --> 02:16:13,920
WE JUST ISSUED THE OTA FOR

3399
02:16:13,920 --> 02:16:14,360
PATHOBIOLOGY GRANTS.

3400
02:16:14,360 --> 02:16:16,640
I WANT TO SAY THANK YOU AGAIN

3401
02:16:16,640 --> 02:16:20,600
FOR BEING SO INCLUSIVE ABOUT

3402
02:16:20,600 --> 02:16:25,080
TRYING TO DISCOVER WHAT REALLY

3403
02:16:25,080 --> 02:16:29,760
IS BEHIND COVID-19'S LONG COVID.

3404
02:16:29,760 --> 02:16:30,840
>> THANK YOU.

3405
02:16:30,840 --> 02:16:38,280
>> WE HAVE TWO OTHER QUESTIONS.

3406
02:16:38,280 --> 02:16:38,840
YADONG AND SHALI.

3407
02:16:38,840 --> 02:16:44,760
>> THANK YOU FOR THE CLEAR TALK.

3408
02:16:44,760 --> 02:16:45,520
QUICK QUESTION, GENDER

3409
02:16:45,520 --> 02:16:49,800
DIFFERENCE IN TERMS OF THIS

3410
02:16:49,800 --> 02:16:50,040
RECOVERY?

3411
02:16:50,040 --> 02:16:54,440
>>  YES, SO WHAT WE KNOW FROM

3412
02:16:54,440 --> 02:16:56,640
THE SELF-REPORTED SYMPTOMS IS

3413
02:16:56,640 --> 02:17:00,920
THAT WOMEN SEEM TO HAVE MORE

3414
02:17:00,920 --> 02:17:03,320
SYMPTOMS THAN MEN, SO FAR,

3415
02:17:03,320 --> 02:17:05,280
SIGNIFICANTLY GREATER NUMBER OF

3416
02:17:05,280 --> 02:17:07,040
SYMPTOMS AND A BROADER ARRAY OF

3417
02:17:07,040 --> 02:17:07,800
SYMPTOMS.

3418
02:17:07,800 --> 02:17:09,640
IT'S A VERY, VERY INTERESTING

3419
02:17:09,640 --> 02:17:12,280
AREA THAT WE DON'T REALLY

3420
02:17:12,280 --> 02:17:13,480
UNDERSTAND BECAUSE I THINK WHAT

3421
02:17:13,480 --> 02:17:15,200
RECOVER WILL ALLOW US TO DO

3422
02:17:15,200 --> 02:17:18,800
WHEN WE REALLY GET INTO THE MORE

3423
02:17:18,800 --> 02:17:19,640
IN-DEPTH PHENOTYPING IS

3424
02:17:19,640 --> 02:17:24,440
UNDERSTAND, YOU KNOW, WHAT ARE

3425
02:17:24,440 --> 02:17:25,040
THE UNDERLYING REASONS FOR

3426
02:17:25,040 --> 02:17:25,440
DIFFERENCES.

3427
02:17:25,440 --> 02:17:28,000
RIGHT NOW WE SORT OF SEE SORT OF

3428
02:17:28,000 --> 02:17:30,920
THE BIG PICTURE OF PEOPLE'S

3429
02:17:30,920 --> 02:17:31,920
EXPERIENCE, BUT WHAT WE NEED TO

3430
02:17:31,920 --> 02:17:35,240
DO IS DELVE INTO THE

3431
02:17:35,240 --> 02:17:36,720
PATHOBIOLOGY AND DELVE INTO SOME

3432
02:17:36,720 --> 02:17:40,320
OF THESE OTHER UNDERLYING RISK

3433
02:17:40,320 --> 02:17:43,360
FACTORS, FOR EXAMPLE, DIFFERENT

3434
02:17:43,360 --> 02:17:46,040
STAGES OF LIFE, AND SO WE -- AS

3435
02:17:46,040 --> 02:17:50,600
WAS JUST POINTED OUT BY THE LAST

3436
02:17:50,600 --> 02:17:52,680
COUNCIL MEMBER, IT'S INCREDIBLY

3437
02:17:52,680 --> 02:17:53,560
COMPLEX AND DIFFICULT TO STUDY

3438
02:17:53,560 --> 02:17:55,920
AND SO WE'VE REALLY TRIED TO

3439
02:17:55,920 --> 02:17:57,120
INCLUDE ALL THE DIFFERENT GROUPS

3440
02:17:57,120 --> 02:17:59,400
THAT WE THOUGHT WERE GOING TO BE

3441
02:17:59,400 --> 02:18:01,320
AT THE HIGHEST RISK.

3442
02:18:01,320 --> 02:18:07,200
>> SO WHAT IS THE BALANCE, THREE

3443
02:18:07,200 --> 02:18:08,120
DIFFERENT TIERS, ABOUT THE

3444
02:18:08,120 --> 02:18:08,440
RECRUITMENT?

3445
02:18:08,440 --> 02:18:09,600
>>  WHAT IS THE BALANCE?

3446
02:18:09,600 --> 02:18:12,480
>>  YEAH, I MEAN THE GENDER

3447
02:18:12,480 --> 02:18:14,480
BALANCE THERE.

3448
02:18:14,480 --> 02:18:15,240
HALF/HALF OR --

3449
02:18:15,240 --> 02:18:19,000
>> YES, YES, I THINK RIGHT NOW

3450
02:18:19,000 --> 02:18:19,360
IT'S HALF/HALF.

3451
02:18:19,360 --> 02:18:21,040
BUT AS WE -- AS I THINK THE

3452
02:18:21,040 --> 02:18:22,840
OPPORTUNITY THAT WE HAVE,

3453
02:18:22,840 --> 02:18:25,880
BECAUSE IT'S AN ITERATIVE

3454
02:18:25,880 --> 02:18:28,680
PROCESS, IS WE'RE ONLY BEGINNING

3455
02:18:28,680 --> 02:18:30,160
WITH THE INITIAL RECRUITMENT, IF

3456
02:18:30,160 --> 02:18:32,560
WE START, WE CAN SORT OF TURN

3457
02:18:32,560 --> 02:18:34,680
THE BOAT, IF YOU WILL, AS WE

3458
02:18:34,680 --> 02:18:36,680
DISCOVER THAT WE WANT TO GO IN A

3459
02:18:36,680 --> 02:18:39,200
PARTICULAR DIRECTION, WE CAN

3460
02:18:39,200 --> 02:18:39,800
OVERSAMPLE PARTICULAR AREAS.

3461
02:18:39,800 --> 02:18:44,560
THAT'S ONE OF THE BEAUTIES OF

3462
02:18:44,560 --> 02:18:46,680
THE TIERS, AND I EXPECT WE'LL BE

3463
02:18:46,680 --> 02:18:49,240
ABLE TO DO THAT.

3464
02:18:49,240 --> 02:18:50,480
>> THANK YOU.

3465
02:18:50,480 --> 02:18:52,480
>> SHALI, GO AHEAD.

3466
02:18:52,480 --> 02:18:55,600
>> YEAH, THANK YOU, DR. WRIGHT,

3467
02:18:55,600 --> 02:18:57,800
FOR THE VERY LUCID COMPREHENSIVE

3468
02:18:57,800 --> 02:19:01,520
OVERVIEW OF THE COMPLEX

3469
02:19:01,520 --> 02:19:02,600
SYNDROME.

3470
02:19:02,600 --> 02:19:06,520
GIVEN THE EXTRAORDINARY SUCCESS

3471
02:19:06,520 --> 02:19:08,480
THAT NIH HAD IN INITIAL

3472
02:19:08,480 --> 02:19:11,880
INITIATIVES RELATED TO COVID,

3473
02:19:11,880 --> 02:19:13,280
PARTICULARLY THE VACCINE

3474
02:19:13,280 --> 02:19:15,240
DEVELOPMENT OPERATION WARP

3475
02:19:15,240 --> 02:19:18,760
SPEED, ARE THERE SIMILAR PLANS

3476
02:19:18,760 --> 02:19:23,200
ALREADY IN PLACE, PLANS TO

3477
02:19:23,200 --> 02:19:25,600
EXPEDITIOUSLY FUND AND IMPLEMENT

3478
02:19:25,600 --> 02:19:28,240
INTERVENTION TRIALS FOR THE

3479
02:19:28,240 --> 02:19:29,840
VARIOUS POSTULATED MECHANISMS

3480
02:19:29,840 --> 02:19:31,560
FOR THIS PARTICULAR --

3481
02:19:31,560 --> 02:19:34,280
>> YES.

3482
02:19:34,280 --> 02:19:36,320
YES, ACTUALLY WE'RE LEVERAGING

3483
02:19:36,320 --> 02:19:40,880
THE MECHANISMS THAT WERE USED IN

3484
02:19:40,880 --> 02:19:45,560
THE DIFFERENT COVID, YOU KNOW, 

3485
02:19:45,560 --> 02:19:46,960
VACCINE SPACE, THE ACTIV

3486
02:19:46,960 --> 02:19:52,320
PROGRAM, AS WELL AS SOME OF THE

3487
02:19:52,320 --> 02:19:55,120
OTHER ONES, TO RESOURCE THAT

3488
02:19:55,120 --> 02:19:56,920
PIECE, THE INTERVENTIONAL PIECE.

3489
02:19:56,920 --> 02:20:02,480
SO, YOU KNOW, THE EARLIER WE CAN

3490
02:20:02,480 --> 02:20:03,280
START WITH SYMPTOMATIC

3491
02:20:03,280 --> 02:20:04,560
TREATMENTS, OBVIOUSLY THAT WILL

3492
02:20:04,560 --> 02:20:06,640
START FIRST, AS WE UNDERSTAND

3493
02:20:06,640 --> 02:20:07,280
PATHOPHYSIOLOGY, AS I MENTIONED

3494
02:20:07,280 --> 02:20:09,240
IN ONE OF THE SLIDES, THEN WE

3495
02:20:09,240 --> 02:20:12,000
CAN START TO SELECT TARGETS TO

3496
02:20:12,000 --> 02:20:14,560
GO AFTER IN DIFFERENT REALMS,

3497
02:20:14,560 --> 02:20:16,640
WHETHER THEY BE ANTI-VIRAL,

3498
02:20:16,640 --> 02:20:17,240
IMMUNE MODULATOR,

3499
02:20:17,240 --> 02:20:18,400
ANTI-INFLAMMATORY, SO ON.

3500
02:20:18,400 --> 02:20:20,680
YES, WE ARE VERY MUCH LEVERAGING

3501
02:20:20,680 --> 02:20:23,320
THE RESOURCES THAT WERE BROUGHT

3502
02:20:23,320 --> 02:20:27,840
TO BEAR ON THE INITIAL COVID

3503
02:20:27,840 --> 02:20:28,440
PANDEMIC.

3504
02:20:28,440 --> 02:20:28,760
>> GREAT.

3505
02:20:28,760 --> 02:20:30,480
IN THE INTEREST OF TIME I THINK

3506
02:20:30,480 --> 02:20:32,440
WE'RE GOING TO HAVE TO MOVE TO

3507
02:20:32,440 --> 02:20:34,440
OUR NEXT SPEAKER, BUT AGAIN I

3508
02:20:34,440 --> 02:20:37,440
WANTED TO THANK DR. WRIGHT FOR

3509
02:20:37,440 --> 02:20:39,200
HIS VERY INFORMATIVE TALK AND

3510
02:20:39,200 --> 02:20:41,240
APPRECIATE YOU TAKING THE TIME

3511
02:20:41,240 --> 02:20:46,000
OUT AND GIVING THE UP THE ON THE

3512
02:20:46,000 --> 02:20:46,720
RECOVER INITIATIVE.

3513
02:20:46,720 --> 02:20:47,640
>> THANK YOU FOR HAVING ME.

3514
02:20:47,640 --> 02:20:51,640
THANK YOU VERY MUCH.

3515
02:20:51,640 --> 02:20:52,840
BYE-BYE.

3516
02:20:52,840 --> 02:20:54,000
>> ALL RIGHT.

3517
02:20:54,000 --> 02:20:58,640
NEXT I'D LIKE TO ASK DR. LIZ

3518
02:20:58,640 --> 02:21:00,160
NEESON TO INTRODUCE THE NEXT

3519
02:21:00,160 --> 02:21:00,560
SPEAKER.

3520
02:21:00,560 --> 02:21:06,040
>> IT'S MY PLEASURE TO INTRODUCE

3521
02:21:06,040 --> 02:21:06,960
DR. ELENA FAZIO, SOCIOLOGIST AND

3522
02:21:06,960 --> 02:21:08,240
PROGRAM OFFICIAL IN THE

3523
02:21:08,240 --> 02:21:09,080
POPULATION AND SOCIAL PROCESSES

3524
02:21:09,080 --> 02:21:11,200
BRANCH OF DIVISION OF BEHAVIORAL

3525
02:21:11,200 --> 02:21:12,960
AND SOCIAL RESEARCH AT NIA WHERE

3526
02:21:12,960 --> 02:21:15,000
SHE MANAGES A PORTFOLIO OF

3527
02:21:15,000 --> 02:21:16,520
RESEARCH ON LONG-TERM SERVICES

3528
02:21:16,520 --> 02:21:18,400
AND SUPPORTS FOR OLDER ADULTS,

3529
02:21:18,400 --> 02:21:20,920
WITH FOCUS ON DEMENTIA CARE AND

3530
02:21:20,920 --> 02:21:23,320
DEMENTIA CARE WORKFORCE.

3531
02:21:23,320 --> 02:21:27,360
IN ADDITION, DR. FAZIO PLAYS A

3532
02:21:27,360 --> 02:21:28,360
LEADING ROLE IN COORDINATING

3533
02:21:28,360 --> 02:21:30,440
ALZHEIMER'S DISEASE APROJECTS

3534
02:21:30,440 --> 02:21:32,160
ACROSS OUR DIVISION INCLUDING

3535
02:21:32,160 --> 02:21:33,400
COORDINATION OF OUR DEMENTIA

3536
02:21:33,400 --> 02:21:35,760
CARE SUMMITS AND SERVING AS

3537
02:21:35,760 --> 02:21:38,040
LIAISON TO NATIONAL ACADEMY ALSO

3538
02:21:38,040 --> 02:21:39,920
ON THIS NIA COMMISSION DECADAL

3539
02:21:39,920 --> 02:21:41,520
SURVEY, THE ROLE OF BEHAVIORAL

3540
02:21:41,520 --> 02:21:43,080
AND SOCIAL SCIENCES CAN PLAY IN

3541
02:21:43,080 --> 02:21:44,200
ADDRESSING THE CHALLENGE OF A.D.

3542
02:21:44,200 --> 02:21:46,600
WHICH SHE WILL BE TALKING TO US

3543
02:21:46,600 --> 02:21:48,600
ABOUT TODAY.

3544
02:21:48,600 --> 02:21:50,000
ELENA, OVER TO YOU.

3545
02:21:50,000 --> 02:21:54,040
>> THANK YOU SO MUCH, LIZ.

3546
02:21:54,040 --> 02:21:56,320
GOOD AFTERNOON, I'M ELENA FAZIO

3547
02:21:56,320 --> 02:21:58,800
FROM NIA DIVISION OF BEHAVIORAL

3548
02:21:58,800 --> 02:22:00,040
AND SOCIAL RESEARCH, BSR FOR

3549
02:22:00,040 --> 02:22:00,480
SHORT.

3550
02:22:00,480 --> 02:22:02,880
TODAY I WILL BE TALKING ABOUT

3551
02:22:02,880 --> 02:22:05,520
NATIONAL ACADEMIES OF SCIENCE,

3552
02:22:05,520 --> 02:22:06,480
ENGINEERING AND MEDICINE REPORT

3553
02:22:06,480 --> 02:22:08,640
REDUCING IMPACT OF DEMENTIA IN

3554
02:22:08,640 --> 02:22:12,640
AMERICA, DECADAL SURVEY.

3555
02:22:12,640 --> 02:22:14,200
NEXT SLIDE.

3556
02:22:14,200 --> 02:22:17,040
I WILL PROVIDE BACKGROUND ON

3557
02:22:17,040 --> 02:22:22,600
WHAT IS A DECADAL SURVEY AND

3558
02:22:22,600 --> 02:22:25,640
TURN TO REPORT RECOMMENDATIONS

3559
02:22:25,640 --> 02:22:26,120
COUPLED WITH RESEARCH

3560
02:22:26,120 --> 02:22:27,360
INITIATIVES IN PROJECT AND LOOK

3561
02:22:27,360 --> 02:22:30,440
TOWARD THE FUTURE.

3562
02:22:30,440 --> 02:22:32,400
NEXT SLIDE.

3563
02:22:32,400 --> 02:22:36,320
WHAT IS A DECADAL SURVEY? 

3564
02:22:36,320 --> 02:22:37,440
A METHOD TO ENGAGE MEMBERS OF

3565
02:22:37,440 --> 02:22:38,640
THE RESEARCH COMMUNITY TO

3566
02:22:38,640 --> 02:22:40,720
IDENTIFY LINES OF RESEARCH WITH

3567
02:22:40,720 --> 02:22:42,480
GREATEST POTENTIAL FOR IMPACT

3568
02:22:42,480 --> 02:22:44,520
OVER A TEN-YEAR PERIOD IN THE

3569
02:22:44,520 --> 02:22:46,640
PURSUIT OF A PARTICULAR GOAL.

3570
02:22:46,640 --> 02:22:48,680
IT IS A SURVEY OF THE FIELD, SO

3571
02:22:48,680 --> 02:22:50,520
TO SPEAK.

3572
02:22:50,520 --> 02:22:52,160
NATIONAL ACADEMIES PIONEERED

3573
02:22:52,160 --> 02:22:56,080
THIS APPROACH IN 1964, HIGHLY

3574
02:22:56,080 --> 02:23:00,000
REGARDED BUT SPARINGLY USED.

3575
02:23:00,000 --> 02:23:01,960
FEWER THAN TWODOZEN SURVEYS

3576
02:23:01,960 --> 02:23:03,520
CONDUCTED, TEN YEAR RESEARCH

3577
02:23:03,520 --> 02:23:05,200
AGENDA FOR BEHAVIORAL AND SOCIAL

3578
02:23:05,200 --> 02:23:06,560
SCIENCE RESEARCH ON DEMENTIAS.

3579
02:23:06,560 --> 02:23:09,400
SO AGAIN THE GOAL IS IN FACT

3580
02:23:09,400 --> 02:23:11,920
THIS TEN-YEAR AGENDA.

3581
02:23:11,920 --> 02:23:19,240
THE WHO IS AN AD HOC COMMITTEE

3582
02:23:19,240 --> 02:23:21,240
AND ADVISORY PANEL.

3583
02:23:21,240 --> 02:23:24,440
THE PROCESS INCLUDED INFORMATION

3584
02:23:24,440 --> 02:23:25,520
GATHERING, REALLY CAREFUL

3585
02:23:25,520 --> 02:23:37,680
DELIBERATION IN THE SERVICE OF

3586
02:23:37,680 --> 02:23:38,640
REPORT CREATION.

3587
02:23:38,640 --> 02:23:40,640
COMMITTEE MEMBERS REPORT A BROAD

3588
02:23:40,640 --> 02:23:44,800
SET OF DISCIPLINES FROM

3589
02:23:44,800 --> 02:23:55,520
ECONOMICS TO BIOETHICS HEALTH

3590
02:23:55,520 --> 02:23:58,840
SERVICES, AND BEYOND.

3591
02:23:58,840 --> 02:24:06,880
THE 

3592
02:24:06,880 --> 02:24:09,240
THE STAFF RELATED TO DECADAL

3593
02:24:09,240 --> 02:24:11,000
SURVEY TO ENSURE THAT

3594
02:24:11,000 --> 02:24:12,120
PERSPECTIVES FROM THE COMMUNITY

3595
02:24:12,120 --> 02:24:14,800
OF INDIVIDUALS DIRECTLY AFFECTED

3596
02:24:14,800 --> 02:24:17,440
BY DEMENTIA WERE INCLUDED IN THE

3597
02:24:17,440 --> 02:24:18,600
INFORMATION GATHERED TO ADDRESS

3598
02:24:18,600 --> 02:24:19,880
THE STUDY CHARGE.

3599
02:24:19,880 --> 02:24:23,040
THEY ALSO PROPOSED REPORT THAT

3600
02:24:23,040 --> 02:24:24,840
COALESCED AROUND FOUR THEMES,

3601
02:24:24,840 --> 02:24:26,040
INCLUDING DIFFICULTY IN

3602
02:24:26,040 --> 02:24:28,760
OBTAINING ACCURATE AND TIMELY

3603
02:24:28,760 --> 02:24:31,040
DEMENTIA DIAGNOSIS, PROBLEMS IN

3604
02:24:31,040 --> 02:24:33,080
OBTAINING SUPPORTS AND SERVICES,

3605
02:24:33,080 --> 02:24:34,880
COMMUNICATION CHALLENGES, FEAR

3606
02:24:34,880 --> 02:24:37,000
AND LOSS.

3607
02:24:37,000 --> 02:24:38,360
TWO CURRENT COUNCIL MEMBERS

3608
02:24:38,360 --> 02:24:39,680
PLAYED KEY ROLES IN THIS

3609
02:24:39,680 --> 02:24:40,560
PROCESS.

3610
02:24:40,560 --> 02:24:43,280
WE'D LIKE TO THANK IN PARTICULAR

3611
02:24:43,280 --> 02:24:45,720
CYNTHIA HUMMEL AND DAVID REUBEN.

3612
02:24:45,720 --> 02:24:49,960
NEXT SLIDE. 

3613
02:24:49,960 --> 02:24:56,120
DECADAL REPORT

3614
02:24:56,120 --> 02:24:58,560
>> SOCIAL AS WELL AS THE V.A. 

3615
02:24:58,560 --> 02:24:59,600
THE OFFICE OF THE ASSISTANT 

3616
02:24:59,600 --> 02:25:02,240
SECRETARY OF PLANNING AND 

3617
02:25:02,240 --> 02:25:05,160
EVALUATION, AARP, ALZHEIMER'S 

3618
02:25:05,160 --> 02:25:07,080
ASSOCIATION AND THE AMERICAN 

3619
02:25:07,080 --> 02:25:11,160
PSYCHOLOGICAL ASSOCIATION, JPB 

3620
02:25:11,160 --> 02:25:13,440
AND THE JOHN H. HARTFORD 

3621
02:25:13,440 --> 02:25:14,120
FOUNDATION.

3622
02:25:14,120 --> 02:25:19,040
WHY DID NIA INVEST IN THE 

3623
02:25:19,040 --> 02:25:19,640
SURVEY?

3624
02:25:19,640 --> 02:25:22,240
ALZHEIMER'S DISEASE AND RELATED 

3625
02:25:22,240 --> 02:25:23,200
DEMENTIA EXPANDS MANY TOPICS AND

3626
02:25:23,200 --> 02:25:26,480
WE FUNDED THIS WORK TO CREATE A 

3627
02:25:26,480 --> 02:25:29,800
BROAD 10-YEAR RESEARCH AGENDA 

3628
02:25:29,800 --> 02:25:31,160
WITH GREATEST POTENTIAL IMPACT.

3629
02:25:31,160 --> 02:25:32,280
THE AD HOC COMMITTEE WAS CHARGED

3630
02:25:32,280 --> 02:25:35,040
WITH DEVELOPING THIS AGENDA IN 

3631
02:25:35,040 --> 02:25:37,120
THE FOLLOWING AREAS, POPULATION 

3632
02:25:37,120 --> 02:25:38,520
EPIDEMIOLOGY, BEHAVIORAL AND 

3633
02:25:38,520 --> 02:25:40,600
SOCIAL RISK FACTORS AND 

3634
02:25:40,600 --> 02:25:43,240
UNDERLYING CAUSAL PATHWAYS 

3635
02:25:43,240 --> 02:25:46,200
TOWARDS DEMENTIA, PRIMARY AND 

3636
02:25:46,200 --> 02:25:51,240
SECONDARY DEMENTIA PREVENTION, 

3637
02:25:51,240 --> 02:25:52,320
FINANCING AND LIVING WITH 

3638
02:25:52,320 --> 02:25:55,120
DEMENTIA AND THE WORK FORCE AND 

3639
02:25:55,120 --> 02:25:59,160
INTERVENTIONS WITH PEOPLE LIVING

3640
02:25:59,160 --> 02:26:03,160
WITH DEMENTIA AND HIGH RISK 

3641
02:26:03,160 --> 02:26:06,840
POPULATIONS AND METHODOLOGICAL 

3642
02:26:06,840 --> 02:26:07,120
APPROACHES.

3643
02:26:07,120 --> 02:26:10,960
THE COMMITTEE IDENTIFIED FIVE 

3644
02:26:10,960 --> 02:26:12,400
PRIORITIES TO ENSURE THE 

3645
02:26:12,400 --> 02:26:13,560
BEHAVIORAL AND SOCIAL SCIENCE 

3646
02:26:13,560 --> 02:26:15,680
WILL HAVE A MAXIMUM IMPACT IN 

3647
02:26:15,680 --> 02:26:19,800
REDUCING THE NEGATIVE IMPACTS OF

3648
02:26:19,800 --> 02:26:20,960
DEMENTIA AND THE GREATER FOCUS 

3649
02:26:20,960 --> 02:26:22,120
ON THE LIVED EXPERIENCE OF 

3650
02:26:22,120 --> 02:26:24,400
DEMENTIA AND DESIGNING STUDIES 

3651
02:26:24,400 --> 02:26:25,520
WITH POTENTIAL TO RECTIFY 

3652
02:26:25,520 --> 02:26:27,240
INEQUITIES AND DISPARITIES, 

3653
02:26:27,240 --> 02:26:30,440
THIRD, THE NEED FOR INNOVATIVE 

3654
02:26:30,440 --> 02:26:32,240
METHODOLOGIES AND MEASUREMENT, 

3655
02:26:32,240 --> 02:26:33,480
FOURTH, GREATER ATTENTION TO 

3656
02:26:33,480 --> 02:26:37,440
COST AND ECONOMIC ANALYSES AND 

3657
02:26:37,440 --> 02:26:42,520
FIFTH, STRENGTHENING RESEARCH 

3658
02:26:42,520 --> 02:26:44,080
INFRASTRUCTURE INCLUDING 

3659
02:26:44,080 --> 02:26:44,360
RESOURCES.

3660
02:26:44,360 --> 02:26:47,200
THE EIGHT CHAPTERS OFFER 

3661
02:26:47,200 --> 02:26:48,400
RECOMMENDATIONS FOR ADVANCING 

3662
02:26:48,400 --> 02:26:53,480
RESEARCH ON RISK FACTORS AND 

3663
02:26:53,480 --> 02:26:54,800
PREVENTION, IMPROVING FACTORS 

3664
02:26:54,800 --> 02:26:56,320
AND ADDRESSING THE DIVERSE NEEDS

3665
02:26:56,320 --> 02:26:58,320
OF CAREGIVERS, ENHANCING OUR 

3666
02:26:58,320 --> 02:26:59,320
INFORMATION OF HOW COMMUNITY 

3667
02:26:59,320 --> 02:27:01,200
RESOURCES CAN BE MOBILIZED, 

3668
02:27:01,200 --> 02:27:03,600
IMPROVING MODELS OF CARE ACROSS 

3669
02:27:03,600 --> 02:27:05,840
THE WHOLE DISEASE DISEASE 

3670
02:27:05,840 --> 02:27:07,520
CONTINUUM, GETTING ON THE HANDLE

3671
02:27:07,520 --> 02:27:09,440
OF COSTS AND STUDY FINANCIAL 

3672
02:27:09,440 --> 02:27:11,400
INCENTIVES AND FINALLY PROMOTING

3673
02:27:11,400 --> 02:27:13,840
RIGOR AND MEASUREMENT OF 

3674
02:27:13,840 --> 02:27:15,240
ENVIRONMENTAL AND SOCIAL 

3675
02:27:15,240 --> 02:27:20,560
EXPOSURES AND COGNITIVE 

3676
02:27:20,560 --> 02:27:25,080
OUTCOMES.

3677
02:27:25,080 --> 02:27:27,240
SEVERAL RESEARCH PRIORITIES ARE 

3678
02:27:27,240 --> 02:27:32,200
ALIGNED WITH THE SRs 

3679
02:27:32,200 --> 02:27:33,640
INITIATIVES.

3680
02:27:33,640 --> 02:27:34,160
THIS MEANS OUR SCAN OF 

3681
02:27:34,160 --> 02:27:36,840
LITERATURE AND OTHER EXPERT 

3682
02:27:36,840 --> 02:27:37,840
INPUTS ARE ALIGNED IN TERMS OF 

3683
02:27:37,840 --> 02:27:42,440
FUTURE PRIORITIES.

3684
02:27:42,440 --> 02:27:44,680
THE REPORT PROVIDES 150 

3685
02:27:44,680 --> 02:27:46,840
RECOMMENDATIONS.

3686
02:27:46,840 --> 02:27:48,120
WILL NOT TEAMED TO COVER THEM 

3687
02:27:48,120 --> 02:27:50,400
ALL SINCE THEY'RE BROAD AND 

3688
02:27:50,400 --> 02:27:50,960
DEEP.

3689
02:27:50,960 --> 02:27:55,200
I'LL HIGHLIGHT A FEW EXAMPLES.

3690
02:27:55,200 --> 02:27:56,920
RESEARCH TOPICS WERE SIGNIFICANT

3691
02:27:56,920 --> 02:28:02,520
PROGRESS HAS BEEN MADE, RESEARCH

3692
02:28:02,520 --> 02:28:05,040
AREAS THAT ARE AND THOSE TOPICS 

3693
02:28:05,040 --> 02:28:07,600
THAT CAN CATEGORIZED AS EARLY 

3694
02:28:07,600 --> 02:28:08,840
STAGES AND I'LL DISCUSS PROGRESS

3695
02:28:08,840 --> 02:28:10,000
MADE AND RESEARCH OPPORTUNITIES 

3696
02:28:10,000 --> 02:28:15,920
THAT SPEAK TO AND ADD TO THE 

3697
02:28:15,920 --> 02:28:17,600
10-YEAR RESEARCH AGENDA.

3698
02:28:17,600 --> 02:28:18,880
FIRST THE COMMITTEE IDENTIFIED 

3699
02:28:18,880 --> 02:28:21,560
CAUSAL AFFECTS OF SOCIAL FACTORS

3700
02:28:21,560 --> 02:28:23,680
OF HEALTH RELATED BEHAVIORALS AS

3701
02:28:23,680 --> 02:28:25,520
A KEY RECOMMENDATIONATION AREA.

3702
02:28:25,520 --> 02:28:27,240
THIS CAN MEAN MANY THINGS 

3703
02:28:27,240 --> 02:28:28,400
INCLUDING HOW SOCIAL FACTORS 

3704
02:28:28,400 --> 02:28:32,520
MIGHT IMPACT THE INCIDENTS AND 

3705
02:28:32,520 --> 02:28:34,520
RATE OF PROGRESSION OF DEMENTIA 

3706
02:28:34,520 --> 02:28:36,320
AND HEALTH RELATED BEHAVIORS AND

3707
02:28:36,320 --> 02:28:37,600
THEIR MANAGEMENT OVER THE LIFE 

3708
02:28:37,600 --> 02:28:39,040
COURSE.

3709
02:28:39,040 --> 02:28:41,600
IN ADDITION, MODIFIABLE DRIVERS 

3710
02:28:41,600 --> 02:28:45,480
OF RACIAL AND ETHNIC INEQUITY 

3711
02:28:45,480 --> 02:28:50,520
AND OTHER DIMENSIONS OF 

3712
02:28:50,520 --> 02:28:55,200
INEQUALITY AND THERE'S AN RFA ON

3713
02:28:55,200 --> 02:28:56,520
THE RELATIONSHIP BETWEEN 

3714
02:28:56,520 --> 02:28:58,600
EDUCATION AND COGNITION AND THE 

3715
02:28:58,600 --> 02:29:00,360
HIGH SCHOOL AND BEYOND RESOURCES

3716
02:29:00,360 --> 02:29:03,240
AND A NEW CENTER ON EMOTIONAL 

3717
02:29:03,240 --> 02:29:07,200
WELL BEING AND BRAIN AGING.

3718
02:29:07,200 --> 02:29:11,280
AS PREVIOUSLY MENTIONED, IT'S AN

3719
02:29:11,280 --> 02:29:13,680
NIA SUPPORTED DATA SOURCE AND 

3720
02:29:13,680 --> 02:29:16,200
HAS RICH EARLY LIFE COURSE 

3721
02:29:16,200 --> 02:29:20,040
MEASURES, DATA FOR SOME 

3722
02:29:20,040 --> 02:29:21,600
PARTICIPANTS STARTS AS EARLY AS 

3723
02:29:21,600 --> 02:29:23,840
AS ADOLESCENCE AND HAS A DIVERSE

3724
02:29:23,840 --> 02:29:25,560
SAMPLE.

3725
02:29:25,560 --> 02:29:26,600
EDUCATIONAL EXPERIENCES OF AAD 

3726
02:29:26,600 --> 02:29:28,560
HEALTH MEMBERS AND THE SCHOOLS 

3727
02:29:28,560 --> 02:29:30,560
THEY ATTENDED ARE INCLUDED FOR 

3728
02:29:30,560 --> 02:29:32,600
SOME INCLUDING ALL THE WAY TO 

3729
02:29:32,600 --> 02:29:33,880
MIDDLE SCHOOL AND GRADES 

3730
02:29:33,880 --> 02:29:35,040
RECEIVED, WHAT CLASSES PEOPLE 

3731
02:29:35,040 --> 02:29:35,640
TOOK AND WHAT THEIR SCHOOLS 

3732
02:29:35,640 --> 02:29:44,560
LOOKED LIKE.

3733
02:29:44,560 --> 02:29:46,280
IT SUPPORTED UNIVERSITY OF 

3734
02:29:46,280 --> 02:29:54,240
VERMONT FOR RISK.

3735
02:29:54,240 --> 02:29:56,240
THE COMMITTEE SUGGESTS SEVERAL 

3736
02:29:56,240 --> 02:29:57,400
AREAS FOR EXPLORATION AND 

3737
02:29:57,400 --> 02:30:00,080
MODIFIABLE DRIVERS OF RACIAL AND

3738
02:30:00,080 --> 02:30:02,080
ETHNIC IN EQUALITY AND 

3739
02:30:02,080 --> 02:30:03,240
IDENTIFYING RISK FACTORS THAT 

3740
02:30:03,240 --> 02:30:07,000
CAN BE THE BASIS FOR PRECISE 

3741
02:30:07,000 --> 02:30:08,520
RECOMMENDATIONS FOR INDIVIDUALS 

3742
02:30:08,520 --> 02:30:09,640
ABOUT DECISION MAKING AND 

3743
02:30:09,640 --> 02:30:11,680
POPULATION LEVEL POLICIES TO 

3744
02:30:11,680 --> 02:30:14,600
PROMOTE BRAIN HEALTH AND 

3745
02:30:14,600 --> 02:30:18,040
CONDUCTING LONGITUDINAL HEALTH 

3746
02:30:18,040 --> 02:30:18,680
AND CHANGE AND DEMENTIA OUTCOMES

3747
02:30:18,680 --> 02:30:23,440
IS ALSO NEEDED.

3748
02:30:23,440 --> 02:30:25,440
THE REPORT S ADVANCED IN DATA 

3749
02:30:25,440 --> 02:30:27,600
COLLECTION AND RESEARCH 

3750
02:30:27,600 --> 02:30:30,680
METHODOLOGY ARE NEEDED TO 

3751
02:30:30,680 --> 02:30:32,600
SUPPORT PROGRESS IN VIRTUALLY 

3752
02:30:32,600 --> 02:30:34,080
EVERY DOMAIN.

3753
02:30:34,080 --> 02:30:35,440
NIH'S DIVISION OF BEHAVIORAL AND

3754
02:30:35,440 --> 02:30:38,160
SOCIAL SCIENCES INVESTED IN THIS

3755
02:30:38,160 --> 02:30:40,920
TYPE OF DATA INFRASTRUCTURE WITH

3756
02:30:40,920 --> 02:30:42,480
EMPHASIS ON SEVERAL FLAGSHIP 

3757
02:30:42,480 --> 02:30:46,640
STUDIES LIKE THE HEALTH AND 

3758
02:30:46,640 --> 02:30:47,480
RETIREMENT STUDY AS WELL AS 

3759
02:30:47,480 --> 02:30:49,720
SUPPORT FOR TECHNOLOGY FOCUSSED 

3760
02:30:49,720 --> 02:30:50,560
RESEARCH AND INFRASTRUCTURE.

3761
02:30:50,560 --> 02:30:53,880
IT'S A LONGITUDINAL PANEL STUDY 

3762
02:30:53,880 --> 02:30:57,000
THAT SURVEYS A REPRESENTATIVE 

3763
02:30:57,000 --> 02:30:58,840
SAMPLE OF APPROXIMATELY 20,000 

3764
02:30:58,840 --> 02:31:02,360
PEOPLE IN AMERICA 50 YEARS AND 

3765
02:31:02,360 --> 02:31:02,560
OLDER.

3766
02:31:02,560 --> 02:31:04,680
IT PROVIDES AN INVALUABLE BODY 

3767
02:31:04,680 --> 02:31:07,040
OF RESEARCH DATA RESEARCHERS CAN

3768
02:31:07,040 --> 02:31:08,240
USE TO ADDRESS IMPORTANT 

3769
02:31:08,240 --> 02:31:09,920
QUESTION THE CHALLENGES AND 

3770
02:31:09,920 --> 02:31:11,720
OPPORTUNITIES OF AGING.

3771
02:31:11,720 --> 02:31:13,280
THIS MAP YOU SEE ON THE SCREEN 

3772
02:31:13,280 --> 02:31:17,400
ILLUSTRATE THE VARIOUS PLACES 

3773
02:31:17,400 --> 02:31:22,040
AROUND THE WORLD INTERNATIONAL 

3774
02:31:22,040 --> 02:31:25,720
STUDIES ARE CONDUCTED INCLUDING 

3775
02:31:25,720 --> 02:31:28,360
LOW AND MIDDLE INCOME COUNTRIES 

3776
02:31:28,360 --> 02:31:33,240
LIKE CHINA, MEXICO AND INDIA AND

3777
02:31:33,240 --> 02:31:35,440
THIS CAN HELP INFORM THE 

3778
02:31:35,440 --> 02:31:37,960
U.S. AND BEYOND AND THE PROTOCOL

3779
02:31:37,960 --> 02:31:42,960
IS AN ONGOING INTERNATIONAL 

3780
02:31:42,960 --> 02:31:44,840
MEASURE TO UNDERSTAND DEMENTIA 

3781
02:31:44,840 --> 02:31:49,040
RISK WITHIN LONGITUDINAL STUDIES

3782
02:31:49,040 --> 02:31:51,680
AROUND THE WORLD TO FACILITATE 

3783
02:31:51,680 --> 02:31:52,800
ACROSS NATIONAL COMPARISONS.

3784
02:31:52,800 --> 02:31:55,640
IT'S ASSOCIATED WITH A GROWING 

3785
02:31:55,640 --> 02:31:58,280
NUMBER OF HRS SISTER STUDIES AND

3786
02:31:58,280 --> 02:32:01,680
WILL CONTINUE TO ADDRESS A 

3787
02:32:01,680 --> 02:32:02,560
NUMBER OF THE TODAY REPORT 

3788
02:32:02,560 --> 02:32:13,320
RECOMMENDS.

3789
02:32:13,320 --> 02:32:17,640
AS EXPRESSED BY THE COMMITTEE 

3790
02:32:17,640 --> 02:32:20,600
INCLUDES TOUGHERSES FOR NEW AND 

3791
02:32:20,600 --> 02:32:23,240
INNOVATIVE SOURCES AND NEW DATA 

3792
02:32:23,240 --> 02:32:26,360
SETS AND THE EVALUATION OF 

3793
02:32:26,360 --> 02:32:27,880
BIASES AND SELECTION OF 

3794
02:32:27,880 --> 02:32:29,040
PARTICIPANTS AND BIASES AND 

3795
02:32:29,040 --> 02:32:29,800
MEASUREMENT DEVELOPMENT.

3796
02:32:29,800 --> 02:32:32,640
THE TOPIC OF INCLUSIVE RESEARCH 

3797
02:32:32,640 --> 02:32:33,880
PARTICIPATION CAN SPEAK TO THE 

3798
02:32:33,880 --> 02:32:38,600
INCLUSION OF THOSE WITH AND 

3799
02:32:38,600 --> 02:32:43,240
WITHOUT COGNITIVE IMPAIRMENT AND

3800
02:32:43,240 --> 02:32:46,520
DIVERSITY OF PARTICIPANTS BY 

3801
02:32:46,520 --> 02:32:52,040
RACE, GENDER AND GEOGRAPHY AND 

3802
02:32:52,040 --> 02:32:52,440
BEYOND.

3803
02:32:52,440 --> 02:32:56,560
TURNING TO ANOTHER AREA WE NODE 

3804
02:32:56,560 --> 02:32:59,960
THE DIVISION OF BEHAVIORAL 

3805
02:32:59,960 --> 02:33:02,400
RESEARCH FOCUSSED ON 

3806
02:33:02,400 --> 02:33:04,440
NON-PHARMACOLOGICAL APPROACHES 

3807
02:33:04,440 --> 02:33:08,800
TO PREVENTION MUCH AD/ADRD AND 

3808
02:33:08,800 --> 02:33:09,640
ADDRESSED THE DIFFERENT ASPECT 

3809
02:33:09,640 --> 02:33:13,480
OF INTERVENTION AND DEVELOPMENT.

3810
02:33:13,480 --> 02:33:15,800
A FEW TAKEAWAYS FROM THE 

3811
02:33:15,800 --> 02:33:17,280
WORKSHOP INCLUDE THE NEED TO 

3812
02:33:17,280 --> 02:33:19,680
IDENTIFY BIOMARKERS THAT WOULD 

3813
02:33:19,680 --> 02:33:21,840
SHOW EARLY EVIDENCE OF DISEASE 

3814
02:33:21,840 --> 02:33:22,600
MODIFICATION AND THE IMPORTANCE 

3815
02:33:22,600 --> 02:33:25,640
OF MEASURING COGNITIVE OUTCOMES 

3816
02:33:25,640 --> 02:33:27,400
USING METHODS WITH LARGE SCALE 

3817
02:33:27,400 --> 02:33:29,640
TRIALS OF DIVERSE POPULATIONS, 

3818
02:33:29,640 --> 02:33:31,240
NEED TO DESIGN THE MOST 

3819
02:33:31,240 --> 02:33:33,120
INFORMATIVE TRIALS AND THE NEED 

3820
02:33:33,120 --> 02:33:37,280
TO GENERATE CAUSAL EVIDENCE FROM

3821
02:33:37,280 --> 02:33:43,240
OBSERVAL STUDIES TO NEAR 

3822
02:33:43,240 --> 02:33:47,240
RANDOMIZED CONTROL STUDY OR 

3823
02:33:47,240 --> 02:33:48,080
RCTs.

3824
02:33:48,080 --> 02:33:49,800
RESEARCH OPPORTUNITIES INCLUDE 

3825
02:33:49,800 --> 02:33:51,800
INTERVENTIONS TO MODIFY RISK 

3826
02:33:51,800 --> 02:33:54,280
FACTORS TO REDUCE INCIDENTS MUCH

3827
02:33:54,280 --> 02:33:56,480
DEMENTIA AND ASSESS HOW 

3828
02:33:56,480 --> 02:33:58,040
INTERVENTIONS DELAY OR PREVENT 

3829
02:33:58,040 --> 02:34:00,640
DEMENTIA MAY HAVE EFFECTS ON 

3830
02:34:00,640 --> 02:34:01,120
HEALTH AND HEALTH CARE 

3831
02:34:01,120 --> 02:34:12,840
DISPARITIES.

3832
02:34:12,840 --> 02:34:17,360
THE COMMITTEE IDENTIFIED NEEDS 

3833
02:34:17,360 --> 02:34:18,520
RELATED TO TO DISCLOSURE OF 

3834
02:34:18,520 --> 02:34:20,560
DIAGNOSTIC INFORMATION AND THE 

3835
02:34:20,560 --> 02:34:22,320
USE OF BIESHL 

3836
02:34:26,280 --> 02:34:31,800
BIOMARKERS AND THE IN THECATIONS

3837
02:34:31,800 --> 02:34:37,240
THECATION -- THE INDICATIONS FOR

3838
02:34:37,240 --> 02:34:38,240
PEOPLE SHOWING BIOMARKERS AND 

3839
02:34:38,240 --> 02:34:39,680
USE DIAGNOSTIC TOOLS AND 

3840
02:34:39,680 --> 02:34:40,760
APPROACHES AND QUALITATIVE 

3841
02:34:40,760 --> 02:34:44,520
RESEARCH ON THE IMPACT OF 

3842
02:34:44,520 --> 02:34:47,760
PERSONS RECEIVING A DEMENTIA 

3843
02:34:47,760 --> 02:34:50,520
DIAGNOSES AND UNDER SCORE THE 

3844
02:34:50,520 --> 02:34:55,160
DIGNITY WITH THE PEOPLE WITH 

3845
02:34:55,160 --> 02:34:56,280
DEMENTIA.

3846
02:34:56,280 --> 02:34:58,160
NOTABLE PROGRESS INCLUDES THE 

3847
02:34:58,160 --> 02:35:00,800
NIH MOBILE TOOLBOX AND MOBILE 

3848
02:35:00,800 --> 02:35:04,520
MONITORING FOR COGNITIVE CHANGE,

3849
02:35:04,520 --> 02:35:06,960
ADVANCES IN COGNITIVE SCREENING 

3850
02:35:06,960 --> 02:35:09,080
TOOLS IN ELECTRONIC HEALTH 

3851
02:35:09,080 --> 02:35:14,680
RECORDS AND PRE-CLINICAL OR 

3852
02:35:14,680 --> 02:35:16,440
PRE-SYMPTOMATIC CHANGES THAT MAY

3853
02:35:16,440 --> 02:35:26,560
POINT TO FUTURE DIAGNOSIS.

3854
02:35:26,560 --> 02:35:29,600
THE WORKSHOP SHOWED A 

3855
02:35:29,600 --> 02:35:33,040
PRECLINICAL APPROACH TO AD 

3856
02:35:33,040 --> 02:35:35,440
DIAGNOSES AND CAN WE AFFORD THE 

3857
02:35:35,440 --> 02:35:38,560
COST OF AD/ADRD DIAGNOSTIC 

3858
02:35:38,560 --> 02:35:42,160
APPROACHES IF WHEN THEY ENTER 

3859
02:35:42,160 --> 02:35:44,960
CLINICAL PRACTICE AND HOW 

3860
02:35:44,960 --> 02:35:45,480
PRE-CLINICAL DIAGNOSTIC 

3861
02:35:45,480 --> 02:35:47,200
INFORMATION SHOULD BE DISCLOSED 

3862
02:35:47,200 --> 02:35:49,040
TO STAKEHOLDERS?

3863
02:35:49,040 --> 02:35:51,200
KEY WORKSHOP TAKEAWAYS INCLUDE 

3864
02:35:51,200 --> 02:35:54,760
MOST THE DATA ON RISK OF DECLINE

3865
02:35:54,760 --> 02:35:58,280
AND MARKER EXPOSURE IS ACQUIRED 

3866
02:35:58,280 --> 02:36:00,600
IN NON-REPRESENTED POPULATIONS 

3867
02:36:00,600 --> 02:36:03,440
PRIMARILY IN HIGHLY EDUCATED 

3868
02:36:03,440 --> 02:36:05,000
PEOPLE WILLING TO UNDER GO 

3869
02:36:05,000 --> 02:36:08,960
TESTING IN ACADEMIC CENTERS AND 

3870
02:36:08,960 --> 02:36:09,960
THERE'S LET DATA AVAILABLE IN 

3871
02:36:09,960 --> 02:36:10,840
DIVERSE POPULATIONS IN TERMS OF 

3872
02:36:10,840 --> 02:36:19,240
RACE AND EDGE NICHT.

3873
02:36:19,240 --> 02:36:21,120
-- ETHNICITY.

3874
02:36:21,120 --> 02:36:23,240
THERE'S THE DIFFERENCE SCREEN 

3875
02:36:23,240 --> 02:36:24,640
APPROACHES AND RESEARCH ON WHOM 

3876
02:36:24,640 --> 02:36:28,640
AND WHEN TO SCREEN AND IMPROVED 

3877
02:36:28,640 --> 02:36:30,480
ACCURACY AND SCREENING 

3878
02:36:30,480 --> 02:36:31,200
APPROACHES ACROSS POPULATIONS 

3879
02:36:31,200 --> 02:36:32,640
AND COORDINATION OF RESOURCES 

3880
02:36:32,640 --> 02:36:36,000
FOR PATIENTS ONCE DIAGNOSED.

3881
02:36:36,000 --> 02:36:37,600
THERE'S ALSO A NEED FOR THE 

3882
02:36:37,600 --> 02:36:40,840
REPORT FOR RESEARCH ON THE 

3883
02:36:40,840 --> 02:36:41,600
EVALUATION OF DEMENTIA EDUCATION

3884
02:36:41,600 --> 02:36:42,120
PROGRAMS FOR HEALTH CARE 

3885
02:36:42,120 --> 02:36:50,800
PROVIDERS.

3886
02:36:50,800 --> 02:36:53,640
IN THE REPORTS CHAPTER FOR END 

3887
02:36:53,640 --> 02:36:55,880
OF LIFE CARE AND THOSE LIVING 

3888
02:36:55,880 --> 02:36:57,640
WITH DEMENTIA THERE'S A 

3889
02:36:57,640 --> 02:37:03,160
DISCUSSION HOW THOSE LIVING BIG 

3890
02:37:03,160 --> 02:37:05,040
DEMENTIA AND EMPHASIS ON THOSE 

3891
02:37:05,040 --> 02:37:07,080
RECEIVING CARE END OF LIFE.

3892
02:37:07,080 --> 02:37:08,840
THE NATIONAL INSTITUTE OF AGING 

3893
02:37:08,840 --> 02:37:11,160
ON BEHAVIORAL AND SOCIAL SCIENCE

3894
02:37:11,160 --> 02:37:12,840
FUNDS A CENTER ON PALLIATIVE 

3895
02:37:12,840 --> 02:37:18,240
CARE IN DEMENTIA.

3896
02:37:18,240 --> 02:37:19,120
IT PROVIDES RESEARCH 

3897
02:37:19,120 --> 02:37:20,120
INFRASTRUCTURE AND DEVELOPS 

3898
02:37:20,120 --> 02:37:24,840
TESTS AND IMPLEMENT PALLIATIVE 

3899
02:37:24,840 --> 02:37:25,960
CARE INTERVENTIONS FOR THOSE 

3900
02:37:25,960 --> 02:37:28,360
WITH DEMENTIA AND CAREGIVERS 

3901
02:37:28,360 --> 02:37:30,480
USING ECONOMICS AND DATA SCIENCE

3902
02:37:30,480 --> 02:37:30,760
STRATEGY.

3903
02:37:30,760 --> 02:37:32,080
ANOTHER INFRASTRUCTURE PROJECT 

3904
02:37:32,080 --> 02:37:37,040
FUNDED BY THE DIVISION OF 

3905
02:37:37,040 --> 02:37:41,160
GERIATRICS AND GERONTOLOGY ARE 

3906
02:37:41,160 --> 02:37:41,880
THE INDEPENDENCE CENTER THE ONE 

3907
02:37:41,880 --> 02:37:45,160
AT THE SCHOOL OF MEDICINE AT 

3908
02:37:45,160 --> 02:37:47,000
MOUNT SINAI WHICH CONDUCTS 

3909
02:37:47,000 --> 02:37:52,360
RESEARCH ON PALLIATIVE CARE.

3910
02:37:52,360 --> 02:37:53,800
MORE RESEARCH IS NEEDED.

3911
02:37:53,800 --> 02:37:56,080
END OF LIFE RESEARCH 

3912
02:37:56,080 --> 02:37:57,360
RECOMMENDATIONS FROM THE REPORT 

3913
02:37:57,360 --> 02:37:59,040
INCLUDE THE NEED FOR STUDIES OF 

3914
02:37:59,040 --> 02:38:01,120
THE IMPACT OF ADVANCED CARE 

3915
02:38:01,120 --> 02:38:02,200
PLANNING AT ALL STAGES OF 

3916
02:38:02,200 --> 02:38:06,160
DEMENTIA AND ASSESSMENT OF 

3917
02:38:06,160 --> 02:38:06,440
PREFERENCES.

3918
02:38:06,440 --> 02:38:08,960
THE NEED FOR RESEARCH ON THE 

3919
02:38:08,960 --> 02:38:09,840
EFFECTS OF DIFFERENT TYPES OF 

3920
02:38:09,840 --> 02:38:11,600
DEMENTIA CARE PROGRAMS AND THE 

3921
02:38:11,600 --> 02:38:14,600
TIMING OF HOSPICE REFERRALS AND 

3922
02:38:14,600 --> 02:38:18,760
THE EVALUATION OF THE 

3923
02:38:18,760 --> 02:38:20,160
FEASIBILITY FOR FAMILIES 

3924
02:38:20,160 --> 02:38:24,680
FOREGOING AGGRESSIVE PROCEDURES.

3925
02:38:24,680 --> 02:38:26,120
THE NEXT RECOMMENDATION FOCUSES 

3926
02:38:26,120 --> 02:38:29,800
ON PLATFORMS TO FACILITATE THE 

3927
02:38:29,800 --> 02:38:33,360
FIELDING OF PRAGMATIC AND HEALTH

3928
02:38:33,360 --> 02:38:34,360
CARE SYSTEMS.

3929
02:38:34,360 --> 02:38:35,840
AND THESE ARE DESIGNED TO 

3930
02:38:35,840 --> 02:38:38,440
EVALUATE WHETHER AN INTERVENTION

3931
02:38:38,440 --> 02:38:40,600
CAN IMPROVE HEALTH OUTCOMES 

3932
02:38:40,600 --> 02:38:42,040
UNDER IDEAL HIGHLY CONTROLLED 

3933
02:38:42,040 --> 02:38:42,320
CONDITIONS.

3934
02:38:42,320 --> 02:38:45,240
IN CONTRAST PRAGMATIC CLINICAL 

3935
02:38:45,240 --> 02:38:46,880
TRIALS ARE EMBEDDED IN 

3936
02:38:46,880 --> 02:38:50,120
FUNCTIONING HEALTH CARE SYSTEMS 

3937
02:38:50,120 --> 02:38:53,400
AND DESIGNED TO EVALUATE THE 

3938
02:38:53,400 --> 02:38:56,360
EFFECTIVENESS OF REAL WORLD 

3939
02:38:56,360 --> 02:38:56,800
CONDITIONS.

3940
02:38:56,800 --> 02:39:01,760
THE IMPACT IS TO CONDUCT 

3941
02:39:01,760 --> 02:39:04,560
PRAGMATIC TRIALS OF 

3942
02:39:04,560 --> 02:39:05,240
INTERVENTIONS FOR THOSE LIVING 

3943
02:39:05,240 --> 02:39:07,200
WITH DEMENTIA AND CARE PARTNERS.

3944
02:39:07,200 --> 02:39:11,200
THE IMPACT COLLABORATORY HAS A 

3945
02:39:11,200 --> 02:39:13,440
NEW FUNCTIONING PILOT PROGRAM.

3946
02:39:13,440 --> 02:39:15,240
A COUPLE EXAMPLES OF RECENTLY 

3947
02:39:15,240 --> 02:39:17,920
FUNDED PILOTS INCLUDE ONE 

3948
02:39:17,920 --> 02:39:20,200
WORKING TO IMPROVE ALZHEIMER'S 

3949
02:39:20,200 --> 02:39:22,280
AND RELATED DEMENTIA CARE 

3950
02:39:22,280 --> 02:39:23,240
MANAGEMENT ACROSS IN THE 

3951
02:39:23,240 --> 02:39:25,000
DISCIPLINARY TEAMS AND A SECOND 

3952
02:39:25,000 --> 02:39:26,440
THAT FOCUSES ON DESIGNING MOBILE

3953
02:39:26,440 --> 02:39:30,000
APPS TO HELP ADULT DAY SERVICE 

3954
02:39:30,000 --> 02:39:31,240
CENTERS PREVENT MINOR HEALTH 

3955
02:39:31,240 --> 02:39:36,240
ISSUES FROM ESCALATING.

3956
02:39:36,240 --> 02:39:37,800
THE COLLABORATORY MADE GREAT 

3957
02:39:37,800 --> 02:39:38,440
STRIDES BUT MORE OPPORTUNITIES 

3958
02:39:38,440 --> 02:39:40,480
ARE AVAILABLE.

3959
02:39:40,480 --> 02:39:43,200
THE RECOMMENDATIONS IN THIS AREA

3960
02:39:43,200 --> 02:39:45,560
INCLUDE A FOCUS ON THE 

3961
02:39:45,560 --> 02:39:47,240
EFFECTIVENESS OF PATIENT AND 

3962
02:39:47,240 --> 02:39:49,000
CAREGIVER SUPPORT AND MANAGEMENT

3963
02:39:49,000 --> 02:39:52,720
SYSTEMS EMBEDDED IN HEALTH CARE 

3964
02:39:52,720 --> 02:39:55,960
SYMPTOMS AND SYSTEM CAPACITY FOR

3965
02:39:55,960 --> 02:40:01,120
MULTI-FACETED INTERVENTIONS AND 

3966
02:40:01,120 --> 02:40:03,040
THE NEXT ARE RECOMMENDATIONS IN 

3967
02:40:03,040 --> 02:40:05,080
THE EARLY STAGES OF SCIENTIFIC 

3968
02:40:05,080 --> 02:40:05,400
DEVELOPMENT.

3969
02:40:05,400 --> 02:40:08,040
FIRST AREA IS APPROACHES FOR 

3970
02:40:08,040 --> 02:40:10,600
INTEGRATING AND COORDINATING 

3971
02:40:10,600 --> 02:40:10,800
CARE.

3972
02:40:10,800 --> 02:40:11,840
IDENTIFICATION OF THE EFFECTIVE 

3973
02:40:11,840 --> 02:40:13,640
APPROACHES FOR INTEGRATING CARE 

3974
02:40:13,640 --> 02:40:14,840
SERVICES ACROSS HEALTH CARE 

3975
02:40:14,840 --> 02:40:16,640
DELIVERY AND COMMUNITY-BASED 

3976
02:40:16,640 --> 02:40:17,000
ORGANIZATIONS.

3977
02:40:17,000 --> 02:40:22,040
A SIMILAR TOPIC IS CAPTURED BY 

3978
02:40:22,040 --> 02:40:23,360
APP RESEARCH IMPLEMENTATION 

3979
02:40:23,360 --> 02:40:26,600
MILESTONE MANY ARE FAMILIAR WITH

3980
02:40:26,600 --> 02:40:29,000
THE RESEARCH IMPLEMENTATION 

3981
02:40:29,000 --> 02:40:30,240
MILESTONES ON THE INTEGRATION OF

3982
02:40:30,240 --> 02:40:31,400
LONG-TERM SERVICES AND SUPPORTS,

3983
02:40:31,400 --> 02:40:33,240
HOME BASED CARE AND MEDICAL CARE

3984
02:40:33,240 --> 02:40:35,240
WITH PARTICULAR ATTENTION PAID 

3985
02:40:35,240 --> 02:40:36,640
TO CARE TRANSITIONS.

3986
02:40:36,640 --> 02:40:37,960
RESEARCH OPPORTUNITIES IN THIS 

3987
02:40:37,960 --> 02:40:40,920
AREA INCLUDE THE NEED TO DEVELOP

3988
02:40:40,920 --> 02:40:42,880
AND EVALUATE COMPREHENSIVE CARE 

3989
02:40:42,880 --> 02:40:44,040
MODELS THAT EXPAND HEALTH CARE 

3990
02:40:44,040 --> 02:40:46,200
AND COMMUNITY-BASED 

3991
02:40:46,200 --> 02:40:47,240
ORGANIZATIONS AND STUDY 

3992
02:40:47,240 --> 02:40:48,360
EVIDENCE-BASED MODELS OF 

3993
02:40:48,360 --> 02:40:54,280
DEMENTIA CARE IN RURAL AREAS IN 

3994
02:40:54,280 --> 02:40:56,000
DEMOGRAPHICALLY DIVERSE AREAS.

3995
02:40:56,000 --> 02:41:00,520
PER THE REPORT, MANY GROUPS ARE 

3996
02:41:00,520 --> 02:41:04,640
DEVELOPING INITIATIVES THAT FALL

3997
02:41:04,640 --> 02:41:07,040
UNDER THE UMBRELLA OF DEMENTIA 

3998
02:41:07,040 --> 02:41:07,960
FRIENDLY COMMUNITIES AND FOCUS 

3999
02:41:07,960 --> 02:41:12,760
ON ASSETS THEY BRING AND WAYS OF

4000
02:41:12,760 --> 02:41:14,680
ENGAGING CAREGIVERS IN CARE AND 

4001
02:41:14,680 --> 02:41:15,960
OTHER ISSUES.

4002
02:41:15,960 --> 02:41:17,120
THEY GENERALLY OFFER EDUCATION 

4003
02:41:17,120 --> 02:41:19,080
AND TRAINING FOR MEMBERS OF THE 

4004
02:41:19,080 --> 02:41:21,240
COMMUNITY AND ALSO INCLUDE 

4005
02:41:21,240 --> 02:41:23,760
RESPITE CARE AND OTHER SERVICES.

4006
02:41:23,760 --> 02:41:25,480
RESEARCH OPPORTUNITIES IN THIS 

4007
02:41:25,480 --> 02:41:26,640
AREA INCLUDE DEVELOPING MEASURES

4008
02:41:26,640 --> 02:41:29,520
FOR COMMUNITY-LEVEL OUTCOMES, 

4009
02:41:29,520 --> 02:41:32,120
GENERATING RESEARCH-BASED MODELS

4010
02:41:32,120 --> 02:41:33,440
FOR COLLABORATION AMONG 

4011
02:41:33,440 --> 02:41:35,840
ORGANIZATIONS AND RESOURCES, 

4012
02:41:35,840 --> 02:41:37,600
EVALUATING INNOVATIVE HOUSING 

4013
02:41:37,600 --> 02:41:39,440
ARRANGEMENTS AND MODELLING 

4014
02:41:39,440 --> 02:41:40,440
APPROACHES ON HOW COMMUNITY 

4015
02:41:40,440 --> 02:41:43,840
FACTORS WITHIN A SYSTEM TO 

4016
02:41:43,840 --> 02:41:47,240
IMPLEMENT DEMENTIA RISK AND THE 

4017
02:41:47,240 --> 02:41:54,720
LIVED EXPERIENCE OF DEMENTIA.

4018
02:41:54,720 --> 02:41:55,440
FINANCING STRUCTURES IS ANOTHER 

4019
02:41:55,440 --> 02:41:56,560
EARLY STAGE RECOMMENDATION.

4020
02:41:56,560 --> 02:41:57,760
DEVELOPMENT AND TESTING 

4021
02:41:57,760 --> 02:42:01,920
APPROACHES TO INTEGRATIVE 

4022
02:42:01,920 --> 02:42:02,960
FINANCIAL AND SOCIAL SERVICES IS

4023
02:42:02,960 --> 02:42:06,960
KEY TO PURSUE.

4024
02:42:06,960 --> 02:42:09,800
A NEW AD RESEARCH MILESTONE 13P 

4025
02:42:09,800 --> 02:42:11,200
IS IN ALIGN WITH THIS 

4026
02:42:11,200 --> 02:42:13,480
RECOMMENDATION ACCORDING TO THE 

4027
02:42:13,480 --> 02:42:16,000
COMMITTEE HERE INCLUDE STUDIES 

4028
02:42:16,000 --> 02:42:18,000
OF HOW MEDICARE ADVANTAGE PLANS 

4029
02:42:18,000 --> 02:42:19,800
AND ALTERNATIVE PAYMENT MODELS 

4030
02:42:19,800 --> 02:42:23,240
BEST PROVIDE INCENTIVES TO 

4031
02:42:23,240 --> 02:42:24,640
IMPLEMENT ACTIVE CARE AND 

4032
02:42:24,640 --> 02:42:26,800
LOOKING AT THE EFFECTS OF 

4033
02:42:26,800 --> 02:42:29,240
CHANGES OR DIFFERENCES IN 

4034
02:42:29,240 --> 02:42:30,480
MEDICAID PAYMENT MODELS ON THE 

4035
02:42:30,480 --> 02:42:32,600
QUALITY OF NURSING HOME AND 

4036
02:42:32,600 --> 02:42:35,240
COMMUNITY-BASED SERVICES FOR 

4037
02:42:35,240 --> 02:42:38,040
THOSE LIVING WITH DEMENTIA.

4038
02:42:38,040 --> 02:42:39,160
A FINANCIAL EARLIER STAGE 

4039
02:42:39,160 --> 02:42:40,560
RECOMMENDATION IS TO FURTHER 

4040
02:42:40,560 --> 02:42:43,000
ADDRESS THE CHALLENGE OF 

4041
02:42:43,000 --> 02:42:44,600
MEASURING EXPOSURES AND 

4042
02:42:44,600 --> 02:42:46,240
COGNITIVE OUTCOMES FOR THOSE 

4043
02:42:46,240 --> 02:42:49,920
LIVING WITH DEMENTIA.

4044
02:42:49,920 --> 02:42:56,560
IT'S MER -- MORE RESILIENT AS 

4045
02:42:56,560 --> 02:42:59,360
GROUPS ARE INCLUDED IN RESEARCH 

4046
02:42:59,360 --> 02:43:01,440
AND SELECTION AND RELEVANT 

4047
02:43:01,440 --> 02:43:03,040
EXPOSURES FOR IMPROVEMENT OF 

4048
02:43:03,040 --> 02:43:05,240
QUALITY OF LIFE FOR THOSE LIVING

4049
02:43:05,240 --> 02:43:07,560
WITH DEMENTIA AND CAREGIVERS ARE

4050
02:43:07,560 --> 02:43:08,840
SIMILAR IMPORTANT AND EVOLVING.

4051
02:43:08,840 --> 02:43:10,040
SOCIAL AND BEHAVIORAL 

4052
02:43:10,040 --> 02:43:11,200
RESEARCHERS WILL NEED TO BE 

4053
02:43:11,200 --> 02:43:14,640
FULLY ENGAGED TO CHALLENGE 

4054
02:43:14,640 --> 02:43:16,040
NARROW CONCEPTUALIZATIONS AND 

4055
02:43:16,040 --> 02:43:18,840
RELEVANT RISK FACTORS AND 

4056
02:43:18,840 --> 02:43:19,960
CONSIDER THE IMPLICATIONS OF 

4057
02:43:19,960 --> 02:43:21,920
ALTERNATIVE MEASUREMENT 

4058
02:43:21,920 --> 02:43:22,960
APPROACH.

4059
02:43:22,960 --> 02:43:25,640
THE CHALLENGES OF AMERICA FAMILY

4060
02:43:25,640 --> 02:43:27,880
CENTERED OUTCOMES IN DEMENTIA 

4061
02:43:27,880 --> 02:43:29,640
RESEARCH IS RELEVANT TO NEARLY 

4062
02:43:29,640 --> 02:43:30,880
EVERY TOPIC IN THE REPORT.

4063
02:43:30,880 --> 02:43:32,040
RESEARCH OPPORTUNITIES IN THIS 

4064
02:43:32,040 --> 02:43:34,720
AREA INCLUDE THE DEVELOPMENT OF 

4065
02:43:34,720 --> 02:43:35,920
STANDARDIZED DEFINITIONS AND 

4066
02:43:35,920 --> 02:43:38,040
TOOLS FOR IDENTIFYING DEMENTIA 

4067
02:43:38,040 --> 02:43:40,280
AND CAPTURING STAGES OF DISEASE.

4068
02:43:40,280 --> 02:43:43,560
IMPROVING MEASUREMENT VALIDITY, 

4069
02:43:43,560 --> 02:43:46,080
DEVELOPING SCHOOLS TO SUPPORT 

4070
02:43:46,080 --> 02:43:47,440
CROSSWALKS FROM SPECIMENS FROM 

4071
02:43:47,440 --> 02:43:52,920
DIFFERENT MODALITIES AND 

4072
02:43:52,920 --> 02:43:55,240
MEASUREMENTS FOR DIVERSE 

4073
02:43:55,240 --> 02:44:02,560
POPULATIONS INCLUDING 

4074
02:44:02,560 --> 02:44:05,040
HETEROGENEOUS SETTINGS AND 

4075
02:44:05,040 --> 02:44:06,840
LINGUISTIC BACKGROUNDS.

4076
02:44:06,840 --> 02:44:13,640
THE RECOMMENDATIONS AND THE 

4077
02:44:13,640 --> 02:44:15,200
SUBJECT PROVIDE AN IMPORTANT 

4078
02:44:15,200 --> 02:44:19,200
PATH FORWARD AND INASMUCH AS THE

4079
02:44:19,200 --> 02:44:22,640
PROGRAMS IN AD/SCIENCE AND WE 

4080
02:44:22,640 --> 02:44:24,560
THANK ALL THOSE WHO CONTRIBUTED 

4081
02:44:24,560 --> 02:44:28,720
TO THIS REPORT LAYING OUT A RICH

4082
02:44:28,720 --> 02:44:30,720
AND ACTIONABLE 10-YEAR AGENDA.

4083
02:44:30,720 --> 02:44:31,800
WE HOPE THE RECOMMENDATIONS WILL

4084
02:44:31,800 --> 02:44:34,000
BE TAKEN UP BY THE FIELD ACROSS 

4085
02:44:34,000 --> 02:44:36,600
MANY DISCIPLINES AND ORGANIZERS 

4086
02:44:36,600 --> 02:44:45,640
WITHIN AND BEYOND NIH.

4087
02:44:45,640 --> 02:44:47,480
VISIT OUR WEB PAGES ON AD 

4088
02:44:47,480 --> 02:44:53,000
RESEARCH AND KWON ME MAKT ME OR 

4089
02:44:53,000 --> 02:44:59,120
OTHER STAFF AND CONTACT US.

4090
02:44:59,120 --> 02:45:02,840
>> THANK YOU FOR THE OVERVIEW OF

4091
02:45:02,840 --> 02:45:05,120
THE PUBLICATION AND IT'S 

4092
02:45:05,120 --> 02:45:07,640
IMPLEMENTATION BY NIA.

4093
02:45:07,640 --> 02:45:19,640
DO WE HAVE QUESTIONS FOR ELENA?

4094
02:45:19,640 --> 02:45:22,240
>> THAT WAS TERRIFIC AND WHAT A 

4095
02:45:22,240 --> 02:45:30,440
RICH AGENDA.

4096
02:45:30,440 --> 02:45:30,840
REALLY IMPRESSIVE.

4097
02:45:30,840 --> 02:45:32,440
I HAVE TWO QUESTIONS.

4098
02:45:32,440 --> 02:45:35,120
ONE, ON YOUR END DO YOU HAVE TO 

4099
02:45:35,120 --> 02:45:36,720
ASSESS THE ETHICS REVEALING 

4100
02:45:36,720 --> 02:45:41,680
PEOPLE'S TEST RESULTS AND I WAS 

4101
02:45:41,680 --> 02:45:42,560
WONDERING HOW THOSE DECISIONS 

4102
02:45:42,560 --> 02:45:44,000
GET MADE AND WHO MAKES THOSE 

4103
02:45:44,000 --> 02:45:45,640
DECISIONS ABOUT THE ETHICS OF 

4104
02:45:45,640 --> 02:45:52,440
THAT AND ON THE SECOND QUESTION,

4105
02:45:52,440 --> 02:45:54,200
WE TALKED ABOUT MEASURES AND 

4106
02:45:54,200 --> 02:45:55,600
COMMUNITY LEVEL OUTCOMES AND 

4107
02:45:55,600 --> 02:45:56,120
WONDERED IF YOU CAN GIVE 

4108
02:45:56,120 --> 02:46:08,520
EXAMPLES OF THAT.

4109
02:46:08,520 --> 02:46:10,240
>> THE FIRST QUESTION, I THINK 

4110
02:46:10,240 --> 02:46:14,440
THIS IS BEST SUITED FOR OUR 

4111
02:46:14,440 --> 02:46:17,000
INVESTIGATORS PREPARING FOR AND 

4112
02:46:17,000 --> 02:46:19,520
PROPOSING THEIR STUDIES.

4113
02:46:19,520 --> 02:46:21,400
THIS IS A TREMENDOUSLY IMPORTANT

4114
02:46:21,400 --> 02:46:22,040
TOPIC.

4115
02:46:22,040 --> 02:46:24,080
WE DON'T HAVE -- I DON'T HAVE 

4116
02:46:24,080 --> 02:46:25,400
THE ANSWER TO YOUR QUESTION 

4117
02:46:25,400 --> 02:46:27,280
DIRECTLY IN TERMS OF HOW WE 

4118
02:46:27,280 --> 02:46:29,080
WOULD DEAL WITH THE ETHICAL 

4119
02:46:29,080 --> 02:46:34,040
CONSIDERATIONS BUT IT IS 

4120
02:46:34,040 --> 02:46:36,320
SOMETHING THAT WE WHERE 

4121
02:46:36,320 --> 02:46:38,200
INTERESTED IN STUDY AND THE 

4122
02:46:38,200 --> 02:46:41,920
WORKSHOP ON PRE-SYMPTOMATIC 

4123
02:46:41,920 --> 02:46:43,160
DIAGNOSIS DEALT WITH ETHICAL 

4124
02:46:43,160 --> 02:46:49,000
QUESTIONS BEFO S BROADLY AND
THAT DID 

4125
02:46:49,000 --> 02:46:50,840
TOPIC COME UP AND I'D LIKE TO 

4126
02:46:50,840 --> 02:46:51,880
DISCUSS WHAT WAS DISCUSSED 

4127
02:46:51,880 --> 02:46:53,880
AROUND ETHICS BUT I DON'T HAVE A

4128
02:46:53,880 --> 02:46:54,840
SPECIFIC ANSWER OTHER THAN TO 

4129
02:46:54,840 --> 02:46:56,040
SAY WE'RE INTERESTED IN THAT 

4130
02:46:56,040 --> 02:46:58,920
TOPIC AND IT DID COME UP IN THE 

4131
02:46:58,920 --> 02:46:59,880
WORKSHOP AND THIS MAY HAVE 

4132
02:46:59,880 --> 02:47:01,160
SOMETHING TO ADD TO THAT AS 

4133
02:47:01,160 --> 02:47:01,400
WELL.

4134
02:47:01,400 --> 02:47:03,200
>> ON THAT POINT, I THINK PART 

4135
02:47:03,200 --> 02:47:05,840
OF THE STIMULUS FOR THE WORKSHOP

4136
02:47:05,840 --> 02:47:08,440
THE MORE TARGETED WORKSHOP WAS 

4137
02:47:08,440 --> 02:47:10,720
THE TENSION THAT ARISES BETWEEN 

4138
02:47:10,720 --> 02:47:13,080
THE DESIRE TO GET EVIDENCE OF 

4139
02:47:13,080 --> 02:47:15,040
EARLIER FUNCTIONAL OR 

4140
02:47:15,040 --> 02:47:18,240
PSYCHOLOGICAL CHANGES OR EARLY 

4141
02:47:18,240 --> 02:47:20,560
BIOLOGICAL CHANGES FOR RESEARCH 

4142
02:47:20,560 --> 02:47:22,240
PURPOSES AND POTENTIALLY FOR 

4143
02:47:22,240 --> 02:47:24,680
DIAGNOSTIC PURPOSES IN CLINICAL 

4144
02:47:24,680 --> 02:47:25,960
CONTEXT AND THE QUESTION OF WHAT

4145
02:47:25,960 --> 02:47:30,360
ARE THE IMPLICATION FOR RESEARCH

4146
02:47:30,360 --> 02:47:32,920
PARTICIPANTS OR PATIENTS THANE 

4147
02:47:32,920 --> 02:47:33,480
CASE.

4148
02:47:33,480 --> 02:47:34,480
WE'RE ALL INTERESTED IN MOVING 

4149
02:47:34,480 --> 02:47:36,480
EARLIER TO POTENTIALLY OFFER 

4150
02:47:36,480 --> 02:47:40,600
BENEFIT BUT THE DECISION FOR 

4151
02:47:40,600 --> 02:47:42,280
WHETHER ONE REVEALS THAT IS 

4152
02:47:42,280 --> 02:47:44,560
DIFFERENT FROM THE DECISION IN A

4153
02:47:44,560 --> 02:47:46,440
CLINICAL CONTEXT WHERE I THINK 

4154
02:47:46,440 --> 02:47:48,160
THE MEDICAL COMMUNITY ENDS UP 

4155
02:47:48,160 --> 02:47:49,520
COMING UP WITH RECOMMENDATIONS 

4156
02:47:49,520 --> 02:47:50,080
THERE.

4157
02:47:50,080 --> 02:47:51,400
SO WE WERE GRAPPLING WITH THE 

4158
02:47:51,400 --> 02:47:54,080
ISSUE OPPOSED TO COMING UP WITH 

4159
02:47:54,080 --> 02:47:57,800
AN ANSWER FOR IT, IF YOU WILL.

4160
02:47:57,800 --> 02:47:59,240
>> AROUND ANN, TO YOUR SECOND 

4161
02:47:59,240 --> 02:48:02,240
QUESTION IF I HEARD YOU 

4162
02:48:02,240 --> 02:48:03,440
CORRECTLY I THINK I WERE 

4163
02:48:03,440 --> 02:48:04,600
INTERESTED IN COMMUNITY-LEVEL 

4164
02:48:04,600 --> 02:48:04,880
OUTCOMES.

4165
02:48:04,880 --> 02:48:07,720
THERE'S MANY WAYS TO APPROACH 

4166
02:48:07,720 --> 02:48:08,520
THIS.

4167
02:48:08,520 --> 02:48:10,280
ONE WAY THAT COMES TO MIND IS 

4168
02:48:10,280 --> 02:48:12,160
WHEN I THINK OF ACCESS TO 

4169
02:48:12,160 --> 02:48:13,560
SERVICES AS THE COMMUNITY LEVEL.

4170
02:48:13,560 --> 02:48:16,440
THE AVAILABILITY OF SERVICES AND

4171
02:48:16,440 --> 02:48:20,080
HOW WE WHO GETS THEM AND WHO 

4172
02:48:20,080 --> 02:48:20,320
DOESN'T.

4173
02:48:20,320 --> 02:48:22,680
HOW WELL YOUR COMMUNITY ALLOWS 

4174
02:48:22,680 --> 02:48:25,560
YOU ACCESS AND YOU AND QUALITY 

4175
02:48:25,560 --> 02:48:26,600
OF VERY DIFFERENT SERVICES 

4176
02:48:26,600 --> 02:48:29,960
DEPENDING ON THE NEEDS OF THE 

4177
02:48:29,960 --> 02:48:32,440
PERSON WITH DEMENTIA AND 

4178
02:48:32,440 --> 02:48:32,720
CAREGIVER.

4179
02:48:32,720 --> 02:48:34,920
THERE'S OTHER INFRASTRUCTURE 

4180
02:48:34,920 --> 02:48:37,800
OUTCOMES TO THINK ABOUT AS MENG 

4181
02:48:37,800 --> 02:48:39,200
FROM THE REPORT AND THE DEMENTIA

4182
02:48:39,200 --> 02:48:40,360
FRIENDLY COMMUNITIES BRINGS TO 

4183
02:48:40,360 --> 02:48:42,840
MIND QUESTIONS HOW THE BROADER 

4184
02:48:42,840 --> 02:48:44,040
COMMUNITY IS AVAILABLE TO HELP 

4185
02:48:44,040 --> 02:48:47,000
WITH NOT ONLY SERVICE PROVISION 

4186
02:48:47,000 --> 02:48:49,000
BUT THE PHYSICAL ENVIRONMENT FOR

4187
02:48:49,000 --> 02:48:50,080
THOSE WITH DEMENTIA.

4188
02:48:50,080 --> 02:48:50,760
THOSE ARE TWO EXAMPLES THAT COME

4189
02:48:50,760 --> 02:49:01,320
TO MIND.

4190
02:49:01,320 --> 02:49:03,880
>> THANK YOU, ELENA.

4191
02:49:03,880 --> 02:49:06,880
ANY OTHER QUESTIONS?

4192
02:49:06,880 --> 02:49:17,080
>> THAT WAS A FANTASTIC 

4193
02:49:17,080 --> 02:49:28,560
PRESENTATION.

4194
02:49:28,560 --> 02:49:30,840
THERE'S A STRUCTURAL DETERMINATE

4195
02:49:30,840 --> 02:49:34,400
OF HEALTH IN GENERAL AND VERY 

4196
02:49:34,400 --> 02:49:37,800
IMPORTANT FOR PEOPLE LIVING WITH

4197
02:49:37,800 --> 02:49:38,280
DEMENTIA.

4198
02:49:38,280 --> 02:49:43,240
I THINK IT HAS AN IMPACT ON 

4199
02:49:43,240 --> 02:49:44,120
DETECTION AS WELL THE 

4200
02:49:44,120 --> 02:49:47,200
COMMUNITIES PEOPLE ARE LIVING 

4201
02:49:47,200 --> 02:49:47,360
IN.

4202
02:49:47,360 --> 02:49:49,440
THE KIND OF INFRASTRUCTURE THAT 

4203
02:49:49,440 --> 02:49:53,960
THEY HAVE IN THEIR HOME.

4204
02:49:53,960 --> 02:49:56,000
SO HOW WOULD YOU -- GIVEN WHAT 

4205
02:49:56,000 --> 02:50:01,240
YOU KNOW ABOUT WHAT GRANTEES ARE

4206
02:50:01,240 --> 02:50:03,080
DOING OR WHAT THE VSRs DOING, 

4207
02:50:03,080 --> 02:50:06,920
WHAT ARE THE NEXT STEPS FOR 

4208
02:50:06,920 --> 02:50:12,640
ADDRESSING HOUSING AS IT'S A BIG

4209
02:50:12,640 --> 02:50:26,600
TOPIC AND SOMETHING THAT OFTEN 

4210
02:50:26,600 --> 02:50:29,280
TIMES, I'M AT COLOMBIA 

4211
02:50:29,280 --> 02:50:30,120
UNIVERSITY, WHAT INDIVIDUAL 

4212
02:50:30,120 --> 02:50:34,840
INVESTIGATORS CAN DO TO CHANGE 

4213
02:50:34,840 --> 02:50:36,480
THE HOUSING CONDITIONS.

4214
02:50:36,480 --> 02:50:40,840
>> GREAT QUESTION, JENNIFER.

4215
02:50:40,840 --> 02:50:43,920
FROM MY PERSPECTIVE WHEN WE TALK

4216
02:50:43,920 --> 02:50:45,240
ABOUT HOUSING WE MEAN MANY 

4217
02:50:45,240 --> 02:50:46,640
THINGS AND ISSUES WITH HOUSING 

4218
02:50:46,640 --> 02:50:48,760
STOCK AND DISPARITIES AND 

4219
02:50:48,760 --> 02:50:50,160
AVAILABILITY OF NOT ONLY QUALITY

4220
02:50:50,160 --> 02:50:53,720
BUT FINANCIALLY VIABLE HOUSING.

4221
02:50:53,720 --> 02:50:54,480
THERE'S THE FINANCIAL 

4222
02:50:54,480 --> 02:50:56,560
PERSPECTIVE WHICH WE KNOW PLAYS 

4223
02:50:56,560 --> 02:50:58,560
A ROLE IN HEALTH AND HEALTH CARE

4224
02:50:58,560 --> 02:50:58,960
AS WELL.

4225
02:50:58,960 --> 02:51:00,240
THERE'S A LOT OF INTERCONNECTION

4226
02:51:00,240 --> 02:51:02,000
BUT THE HOUSING PART COULD BE 

4227
02:51:02,000 --> 02:51:03,640
ABOUT FINANCING AND STOCK AND 

4228
02:51:03,640 --> 02:51:06,920
THE TYPE OF HOUSING FOR OLDER 

4229
02:51:06,920 --> 02:51:08,960
ADULTS AND PERSONS LIVING WITH 

4230
02:51:08,960 --> 02:51:10,240
DEMENTIA THEY MAY NEED CERTAIN 

4231
02:51:10,240 --> 02:51:12,760
TYPES OF SUPPORTIVE SERVICES 

4232
02:51:12,760 --> 02:51:14,040
CONSIDERED UNDER THE HOUSING 

4233
02:51:14,040 --> 02:51:14,600
UMBRELLA, IF YOU WILL.

4234
02:51:14,600 --> 02:51:16,080
THERE'S MANY WAYS TO THINK OF 

4235
02:51:16,080 --> 02:51:16,520
HOUSING.

4236
02:51:16,520 --> 02:51:18,080
TO YOUR POINT IN TERMS OF NEXT 

4237
02:51:18,080 --> 02:51:20,600
STEPS, I THINK THERE'S WAYS TO 

4238
02:51:20,600 --> 02:51:24,080
ADDRESS THIS PERHAPS UNDER THE 

4239
02:51:24,080 --> 02:51:25,760
RECOMMENDATION OF DEMENTIA 

4240
02:51:25,760 --> 02:51:27,280
FRIENDLY COMMUNITIES THINKING OF

4241
02:51:27,280 --> 02:51:28,720
THE PHYSICAL ENVIRONMENT AND THE

4242
02:51:28,720 --> 02:51:29,720
EXPERIENCE OF LIVING IN 

4243
02:51:29,720 --> 02:51:30,960
SOMEBODY'S OWN HOME.

4244
02:51:30,960 --> 02:51:32,640
I KNOW SOME OF OUR INVESTIGATORS

4245
02:51:32,640 --> 02:51:35,280
LOOK INTO THOSE WHO LIVE ALONE 

4246
02:51:35,280 --> 02:51:36,560
SO THEY'RE HOME ENVIRONMENT IS 

4247
02:51:36,560 --> 02:51:38,600
VERY DIFFERENT THAN OTHERS AND I

4248
02:51:38,600 --> 02:51:40,080
THINK THAT CONTINUES TO BE A 

4249
02:51:40,080 --> 02:51:41,920
CONCERN IN TERMS OF NOT ONLY THE

4250
02:51:41,920 --> 02:51:43,640
PROVISION OF SERVICES BUT THE 

4251
02:51:43,640 --> 02:51:46,520
THAT WE'RE ABLE TO CONDUCT WITH 

4252
02:51:46,520 --> 02:51:51,640
AND ON THOSE LIVING ALONE WITH 

4253
02:51:51,640 --> 02:51:52,640
DEMENTIA IN THEIR HOME AND 

4254
02:51:52,640 --> 02:51:54,040
THERE'S A MEETING THAT TALKED 

4255
02:51:54,040 --> 02:51:55,440
ABOUT ENVIRONMENTAL FACTORS IN 

4256
02:51:55,440 --> 02:51:55,680
HOUSING.

4257
02:51:55,680 --> 02:51:57,320
YOU MAY HAVE BEEN A PART OF THAT

4258
02:51:57,320 --> 02:51:57,800
DISCUSSION.

4259
02:51:57,800 --> 02:51:59,240
THERE'S A LOT OF THERE AND I 

4260
02:51:59,240 --> 02:52:02,000
WOULD SAY VSR IS POISED TO THINK

4261
02:52:02,000 --> 02:52:05,000
ABOUT HOUSING IN A NUMBER OF 

4262
02:52:05,000 --> 02:52:06,480
DIFFERENT CONTEXTS INCLUDING THE

4263
02:52:06,480 --> 02:52:09,400
ONES I'VE MENTIONED.

4264
02:52:09,400 --> 02:52:11,200
>> GREAT, THANK YOU.

4265
02:52:11,200 --> 02:52:12,680
AND THANK YOU AGAIN FOR YOUR 

4266
02:52:12,680 --> 02:52:14,000
PRESENTATION TODAY.

4267
02:52:14,000 --> 02:52:17,040
I THINK WE'RE GOING MOVE ON THEN

4268
02:52:17,040 --> 02:52:19,240
TO OUR NEXT SPEAKER.

4269
02:52:19,240 --> 02:52:26,240
I'D LIKE TO INVITE RON COHANSKI 

4270
02:52:26,240 --> 02:52:29,320
TO INTRODUCE OUR NEXT SPEAKER.

4271
02:52:29,320 --> 02:52:34,960
>> I THINK WE SWITCHED IT UP ON 

4272
02:52:34,960 --> 02:52:38,000
YOU A LITTLE BIT.

4273
02:52:38,000 --> 02:52:38,600
HI, EVERYBODY.

4274
02:52:38,600 --> 02:52:40,600
I'M CANDACE KERR A PROGRAM 

4275
02:52:40,600 --> 02:52:42,520
OFFICER IN THE DIVISION OF AGING

4276
02:52:42,520 --> 02:52:44,040
BIOLOGY AND PLEASED TO ANNOUNCE 

4277
02:52:44,040 --> 02:52:50,600
DR. WEN WALSH IS A LOCKHART 

4278
02:52:50,600 --> 02:52:51,240
McGUIRE PROFESSOR AT THE 

4279
02:52:51,240 --> 02:52:54,800
UNIVERSITY OF VIRGINIA HIS 

4280
02:52:54,800 --> 02:53:01,560
RESEARCH IS IMPACTING THE AGE OF

4281
02:53:01,560 --> 02:53:03,240
CARDIOVASCULAR BIOLOGY AND LOOK 

4282
02:53:03,240 --> 02:53:05,400
AT INTERTISSUE COMMUNICATION TO 

4283
02:53:05,400 --> 02:53:11,200
UNDERSTAND BETTER THE INTEGRATED

4284
02:53:11,200 --> 02:53:13,960
PHYSIOLOGICAL REASONS TO IMPACT 

4285
02:53:13,960 --> 02:53:16,840
AGING AND HE'S RECEIVED NUMEROUS

4286
02:53:16,840 --> 02:53:22,120
AND AWARDS FROM NHLBI AND THE 

4287
02:53:22,120 --> 02:53:25,960
COUNSEL OF ARTERIOSCLEROSIS THAT

4288
02:53:25,960 --> 02:53:28,760
NAMED HIM AS THE AMERICAN HEART 

4289
02:53:28,760 --> 02:53:29,320
ASSOCIATION DISTINGUISHED 

4290
02:53:29,320 --> 02:53:30,360
SCIENTIST MANY YEARS AGO.

4291
02:53:30,360 --> 02:53:36,040
WHAT BETTER WAY TO STUDY THE 

4292
02:53:36,040 --> 02:53:38,640
INTEGRATIVE THE PATHOPHYSIOLOGY 

4293
02:53:38,640 --> 02:53:41,480
OF AGING AND THIS IS 

4294
02:53:41,480 --> 02:53:47,960
INVESTIGATING HEMATOPOIESIS AND 

4295
02:53:47,960 --> 02:53:50,600
WE LOOK FORWARD TO HEARING MORE 

4296
02:53:50,600 --> 02:54:03,840
ABOUT THIS TODAY.

4297
02:54:03,840 --> 02:54:11,240
I'M GOING TO TELL YOU ABOUT 

4298
02:54:11,240 --> 02:54:19,200
CLONAL HEMATO-POESE -- HEMATO

4299
02:54:19,200 --> 02:54:21,040
HEMATOPOIES

4300
02:54:21,040 --> 02:54:21,400
HEMATOPOIESIS.

4301
02:54:21,400 --> 02:54:23,560
I'LL START WITH A TEXTBOOK 

4302
02:54:23,560 --> 02:54:24,040
DEFINITION.

4303
02:54:24,040 --> 02:54:25,800
IT'S A CONDITION IN WHICH A 

4304
02:54:25,800 --> 02:54:29,280
SUBSTANTIAL PROPORTION OF MATURE

4305
02:54:29,280 --> 02:54:32,440
BLOOD CELLS ARE DEVISED FROM A 

4306
02:54:32,440 --> 02:54:43,160
SINGLE HEMATOPOIETIC STEM CELL 

4307
02:54:43,160 --> 02:54:46,760
AND THERE WAS AN EMERGING VIEW 

4308
02:54:46,760 --> 02:54:50,560
IT'S THOUGHT TO BE A CAUSAL RICK

4309
02:54:50,560 --> 02:54:53,360
FACTOR FOR CARDIOVASCULAR AS 

4310
02:54:53,360 --> 02:54:56,680
PREVALENT FOR THE RISK FACTORS 

4311
02:54:56,680 --> 02:54:59,120
STUDIED FOR RISK FACTORS AND THE

4312
02:54:59,120 --> 02:55:01,560
THINGS THE PRIMARY CARE 

4313
02:55:01,560 --> 02:55:05,040
PHYSICIAN TELLS YOU ABOUT, HYPER

4314
02:55:05,040 --> 02:55:07,120
CHOLESTEROL, DIABETES, SMOKING 

4315
02:55:07,120 --> 02:55:08,440
AND YOUR FAMILY HISTORY.

4316
02:55:08,440 --> 02:55:20,600
YOUR INHERITANCE.

4317
02:55:20,600 --> 02:55:23,040
ADVANCED AGE IS THE GREATEST 

4318
02:55:23,040 --> 02:55:23,960
CARDIOVASCULAR DISEASE FACTOR 

4319
02:55:23,960 --> 02:55:25,480
AND ADVANCED STAGE IS A RISK 

4320
02:55:25,480 --> 02:55:29,640
FACTOR FOR MANY DISEASES, 

4321
02:55:29,640 --> 02:55:30,760
CANCER, ARTHRITIS, ALZHEIMER'S 

4322
02:55:30,760 --> 02:55:31,840
DISEASE AND OTHERS.

4323
02:55:31,840 --> 02:55:34,600
THE ASPECT OF AGING THAT HAS ME 

4324
02:55:34,600 --> 02:55:35,440
PARTICULARLY INTERESTED IN THE 

4325
02:55:35,440 --> 02:55:39,200
LAST FIVE OR SIX YEARS IS 

4326
02:55:39,200 --> 02:55:47,840
REFERRED TO AS SOMATIC MOAISISM 

4327
02:55:47,840 --> 02:55:48,360
IN DEVELOPS.

4328
02:55:48,360 --> 02:55:52,200
IT'S ESTIMATED FROM ULTRA DREAM 

4329
02:55:52,200 --> 02:55:53,920
SEQUENCING THAT PROBABLY BY AGE 

4330
02:55:53,920 --> 02:55:56,560
50 EVERY CELL IN OUR BODY 

4331
02:55:56,560 --> 02:55:59,160
ARETIRED BETWEEN 1,000 AND 

4332
02:55:59,160 --> 02:56:02,280
10,000 SOMATIC MUTATIONS.

4333
02:56:02,280 --> 02:56:04,440
AND THE THING I WANT TO POINT 

4334
02:56:04,440 --> 02:56:06,680
OUT IS THAT BECAUSE CELLS ARE IN

4335
02:56:06,680 --> 02:56:08,120
CONSTANT COMPETITION WITH ONE 

4336
02:56:08,120 --> 02:56:09,320
ANOTHER, IT CAN GIVE RISE TO 

4337
02:56:09,320 --> 02:56:24,360
CLONAL EVENTS.

4338
02:56:24,360 --> 02:56:27,280
THEY EXIST AS A PASSENGER AND 

4339
02:56:27,280 --> 02:56:28,520
SOMETIMES IT HITS AN ESSENTIAL 

4340
02:56:28,520 --> 02:56:31,040
GENE AND THE CELL WILL BE LOST 

4341
02:56:31,040 --> 02:56:33,600
BUT THEY HAPPEN IN GENES THAT 

4342
02:56:33,600 --> 02:56:34,480
ARE CALLED DRIVER GENES THAT 

4343
02:56:34,480 --> 02:56:38,640
GIVE THE SELECTIVE TO THE CELL 

4344
02:56:38,640 --> 02:56:40,920
AND THERE'LL BE A CLONAL 

4345
02:56:40,920 --> 02:56:42,560
EXPANSION AND WHAT WE'VE COME TO

4346
02:56:42,560 --> 02:56:44,240
RECOGNIZE THROUGH MANY STUDIES 

4347
02:56:44,240 --> 02:56:48,600
AS WE AGE, WE BASICALLY BECOME A

4348
02:56:48,600 --> 02:56:51,040
MOSAIC OF PATCH WORK OF THOUSAND

4349
02:56:51,040 --> 02:56:52,920
OF CLONES IN MULTIPLE TISSUES.

4350
02:56:52,920 --> 02:56:56,040
THIS IS SORT OF LISTED HERE.

4351
02:56:56,040 --> 02:56:58,160
THESE ARE JUST SOME OF THE 

4352
02:56:58,160 --> 02:57:02,560
RECENT CELL NATURE SCIENCE 

4353
02:57:02,560 --> 02:57:12,240
PAPERS ON SOMATIC MOSAICIC IN 

4354
02:57:12,240 --> 02:57:12,640
COL

4355
02:57:12,640 --> 02:57:23,040
COLON, BLOOD, ENDOMETRIUM AND 

4356
02:57:23,040 --> 02:57:23,240
BLOOD.

4357
02:57:23,240 --> 02:57:28,800
AND FIRST OF ALL I WOULD SAY 

4358
02:57:28,800 --> 02:57:30,040
CLONAL HEMATOPOIESIS IF YOU 

4359
02:57:30,040 --> 02:57:31,960
THINK ABOUT IT THE WHITE CELLS 

4360
02:57:31,960 --> 02:57:33,400
ARE MULTI-TASKERS AND TRAVEL 

4361
02:57:33,400 --> 02:57:39,040
THROUGHOUT THE BODY AND 

4362
02:57:39,040 --> 02:57:40,480
COMMUNICATE AND ELIMINATE 

4363
02:57:40,480 --> 02:57:42,440
DAMAGED CELLS AND ENABLE US TO 

4364
02:57:42,440 --> 02:57:43,600
COPE WITH THE ENVIRONMENTAL 

4365
02:57:43,600 --> 02:57:45,600
STRESS AND WHEN THEY GET OUT OF 

4366
02:57:45,600 --> 02:57:48,960
CONTROL THEY PARTICIPATE IN 

4367
02:57:48,960 --> 02:57:50,040
MULTIPLE CHRONIC DISEASES SUCH 

4368
02:57:50,040 --> 02:57:50,960
AS CARDIOVASCULAR DISEASE.

4369
02:57:50,960 --> 02:57:53,880
THERE'S BEEN PAPERS ASSOCIATED 

4370
02:57:53,880 --> 02:57:59,360
MUTANT BLOOD CELLS OR MUTATIONS 

4371
02:57:59,360 --> 02:58:03,160
WITH AGING AND IN PAPER THEY 

4372
02:58:03,160 --> 02:58:06,080
ABLATED A DNA REPAIR PROTEIN IN 

4373
02:58:06,080 --> 02:58:18,200
THE HEMATOPOIETIC CELLS AND THE 

4374
02:58:18,200 --> 02:58:21,520
ANIMALS DISPLAYED PREMATURE 

4375
02:58:21,520 --> 02:58:24,040
SENESCENCE AND IMPACTING SUCH 

4376
02:58:24,040 --> 02:58:25,680
THE SYSTEM AFFECT THE HEART, 

4377
02:58:25,680 --> 02:58:27,680
KIDNEYS, BRAIN, METABOLIC 

4378
02:58:27,680 --> 02:58:29,240
SYSTEM, ALL SYSTEMS.

4379
02:58:29,240 --> 02:58:30,600
LED TO SYSTEMIC TISSUE DAMAGE 

4380
02:58:30,600 --> 02:58:32,520
AND DECREASE IN LIFE SPAN.

4381
02:58:32,520 --> 02:58:34,960
THE OTHER ISSUE I WANT TO POINT 

4382
02:58:34,960 --> 02:58:41,040
OUT ABOUT THE HEMATOPOIETIC 

4383
02:58:41,040 --> 02:58:42,600
SYSTEM IS UNDER SELECTIVE 

4384
02:58:42,600 --> 02:58:42,840
PRESSURES.

4385
02:58:42,840 --> 02:58:44,600
BLOOD CELLS ARE TINY AND GET 

4386
02:58:44,600 --> 02:58:45,720
TURNED OVER RAPIDLY.

4387
02:58:45,720 --> 02:58:47,160
THEY'RE LIFE SPANS ARE ON THE 

4388
02:58:47,160 --> 02:58:50,040
ORDER OF 3 TO 120 DAYS AND 

4389
02:58:50,040 --> 02:58:54,680
REPRESENTED 90% OF THE CELLULAR 

4390
02:58:54,680 --> 02:58:57,960
TURNOVER IN THE BODY 370 MILLION

4391
02:58:57,960 --> 02:59:01,400
CELLS A DAY AND FAT AND MUSCLE 

4392
02:59:01,400 --> 02:59:03,040
HAVE LIFE SPANS BETWEEN 12 AND 

4393
02:59:03,040 --> 02:59:03,640
50 YEARS.

4394
02:59:03,640 --> 02:59:05,760
IF THEY GET MUTATED BY A DRIVER 

4395
02:59:05,760 --> 02:59:08,600
GENE, THEY ACQUIRE A MUTATED 

4396
02:59:08,600 --> 02:59:10,720
DRIVER GENE THEY WON'T HAVE THE 

4397
02:59:10,720 --> 02:59:12,040
ABILITY TO UNDER GO THE CLONAL 

4398
02:59:12,040 --> 02:59:17,040
EXPANSION LIKE WHAT WE SEE IN 

4399
02:59:17,040 --> 02:59:19,240
THE HEMATOPOIETIC SYSTEM.

4400
02:59:19,240 --> 02:59:24,720
TO MAKE THIS BITE SIZED THIS IS 

4401
02:59:24,720 --> 02:59:25,560
MY RESEARCH.

4402
02:59:25,560 --> 02:59:32,240
WITHIN THE HEMATOPOIETIC SYSTEM 

4403
02:59:32,240 --> 02:59:33,160
OCCASIONALLY ONE OF THESE 

4404
02:59:33,160 --> 02:59:37,080
MUTATIONS WILL HAPPEN IN A 

4405
02:59:37,080 --> 02:59:38,240
DRIVER GENE THAT HAS A CLONAL 

4406
02:59:38,240 --> 02:59:41,480
EXPANSION AND IT'S A TWO-STAGE 

4407
02:59:41,480 --> 02:59:43,440
PROCESS AND THE CELLS GIVE RISE 

4408
02:59:43,440 --> 02:59:47,160
TO LEUKOCYTES THAT HAVE BEEN 

4409
02:59:47,160 --> 02:59:48,040
GENETICALLY CORRUPTED BECAUSE 

4410
02:59:48,040 --> 02:59:50,040
THEY ALSO HARBOR THE SAME DRIVER

4411
02:59:50,040 --> 02:59:53,280
GENE MUTATION AND THAT COULD 

4412
02:59:53,280 --> 03:00:02,520
IMPACT THEIR PHENOTYPE AND 

4413
03:00:02,520 --> 03:00:04,080
THEREBY IMPACT PROCESSES AND 

4414
03:00:04,080 --> 03:00:06,760
IT'S RELATIVELY EASY TO DETECT 

4415
03:00:06,760 --> 03:00:06,960
THIS.

4416
03:00:06,960 --> 03:00:11,960
YOU BASICALLY DO DEEP SEQUENCING

4417
03:00:11,960 --> 03:00:13,440
OF THE MUTANT ALLELE.

4418
03:00:13,440 --> 03:00:16,240
THERE'S AN EASE OF SAMPLE 

4419
03:00:16,240 --> 03:00:17,640
COLLECTION AND WE HAVE ACCESS TO

4420
03:00:17,640 --> 03:00:18,080
MANY BIOBANKS.

4421
03:00:18,080 --> 03:00:20,520
WHAT ARE SOME OF THE MUTATIONS 

4422
03:00:20,520 --> 03:00:24,040
THAT GIVE RISE TO CLONAL 

4423
03:00:24,040 --> 03:00:24,360
HEMATOPOIESIS?

4424
03:00:24,360 --> 03:00:25,840
THERE'S A WHOLE SPECTRUM.

4425
03:00:25,840 --> 03:00:33,400
WHAT WE MOSTLY FOCUS ON THE CHIP

4426
03:00:33,400 --> 03:00:33,840
DRIV

4427
03:00:33,840 --> 03:00:36,640
GENES AND THESE ARE DRIVER 

4428
03:00:36,640 --> 03:00:36,920
GENES.

4429
03:00:36,920 --> 03:00:38,840
SOME OF THESE ARE RECURRENTLY 

4430
03:00:38,840 --> 03:00:39,960
MUTATED IN BLOOD CANCER.

4431
03:00:39,960 --> 03:00:42,080
IT MAKES SENSE THEY WOULD BE A 

4432
03:00:42,080 --> 03:00:43,240
DRIVER GENE.

4433
03:00:43,240 --> 03:00:47,640
HOWEVER, YOU CAN HAVE MOSAIC 

4434
03:00:47,640 --> 03:00:49,880
CHROMOSOMAL ALTERATIONS WHERE 

4435
03:00:49,880 --> 03:00:57,320
YOU HAVE LOGS OF HETEROZYGOSITY 

4436
03:00:57,320 --> 03:00:59,840
AND WHAT HAPPENED WHAT LED TO 

4437
03:00:59,840 --> 03:01:01,640
THIS RESURGENT INTEREST IN THIS 

4438
03:01:01,640 --> 03:01:02,600
FIELD IS THAT THERE WERE TWO 

4439
03:01:02,600 --> 03:01:06,240
PAPERS PUBLISHED BACK TO BACK IN

4440
03:01:06,240 --> 03:01:07,240
2014 IN THE NEW ENGLAND JOURNAL 

4441
03:01:07,240 --> 03:01:11,200
OF MEDICINE AND BASICALLY SHOWED

4442
03:01:11,200 --> 03:01:12,040
CLONAL HEMATOPOIESIS WAS 

4443
03:01:12,040 --> 03:01:16,440
PROBABLY MORE PREVALENT THAN WE 

4444
03:01:16,440 --> 03:01:17,160
PREVIOUSLY UNDERSTOOD.

4445
03:01:17,160 --> 03:01:18,960
IN A PAPER THERE WAS A CLEAR 

4446
03:01:18,960 --> 03:01:21,240
INCREASE WITH AGE, THE ABILITY 

4447
03:01:21,240 --> 03:01:24,480
FOR THEM TO DETECT CLONAL 

4448
03:01:24,480 --> 03:01:26,640
HEMATOPOIESIS AND WERE USING 

4449
03:01:26,640 --> 03:01:30,800
RELATIVELY INCENSENSITIVE
METHODS 

4450
03:01:30,800 --> 03:01:34,440
BACK THEN AND BUT WHEN 

4451
03:01:34,440 --> 03:01:37,400
INDIVIDUALS REACHED 70, 10% 

4452
03:01:37,400 --> 03:01:38,080
EXHIBITED CLONAL HEMATOPOIESIS 

4453
03:01:38,080 --> 03:01:39,640
AND IT INCREASED GREATER FROM 

4454
03:01:39,640 --> 03:01:39,840
THERE.

4455
03:01:39,840 --> 03:01:40,640
THE THING THAT CAUGHT 

4456
03:01:40,640 --> 03:01:42,120
EVERYBODY'S ATTENTION AT THE 

4457
03:01:42,120 --> 03:01:47,240
TIME WAS IT WAS FOUND THAT 

4458
03:01:47,240 --> 03:01:48,320
INDIVIDUALS THAT HAD CLONAL 

4459
03:01:48,320 --> 03:01:50,640
HEMATOPOIESIS HAD AN INCREASE IN

4460
03:01:50,640 --> 03:01:51,040
MORTALITY.

4461
03:01:51,040 --> 03:01:54,320
THERE WAS ABOUT A 40% IN 

4462
03:01:54,320 --> 03:01:54,920
MORTALITY ON THE FOLLOW-UP 

4463
03:01:54,920 --> 03:01:56,440
PERIOD ON BOTH STUDIES.

4464
03:01:56,440 --> 03:01:57,920
THE QUESTION BECAME, WHAT IS 

4465
03:01:57,920 --> 03:02:01,000
THIS MORTALITY ASSOCIATED WITH 

4466
03:02:01,000 --> 03:02:03,440
AND YOU WOULD THINK WELL, 

4467
03:02:03,440 --> 03:02:04,040
HEMATOLOGIC CANCER PROBABLY 

4468
03:02:04,040 --> 03:02:05,840
BECAUSE WE'RE LOOKING AT THE 

4469
03:02:05,840 --> 03:02:08,000
FIRST STEP IN A LONG PATH 

4470
03:02:08,000 --> 03:02:09,440
DEVELOPING A BLOOD CANCER.

4471
03:02:09,440 --> 03:02:12,520
HOWEVER, THE ISSUE HERE IS THAT 

4472
03:02:12,520 --> 03:02:14,160
BLOOD CANCERS RELATIVELY 

4473
03:02:14,160 --> 03:02:15,280
SPEAKING ARE KIND OF RARE IN THE

4474
03:02:15,280 --> 03:02:19,560
POPULATION AND REALLY CANNOT 

4475
03:02:19,560 --> 03:02:21,640
REALLY ACCOUNT FOR THE BIG 

4476
03:02:21,640 --> 03:02:22,680
INCREASE IN MORTALITY OBSERVED 

4477
03:02:22,680 --> 03:02:23,920
IN THE STUDY.

4478
03:02:23,920 --> 03:02:26,640
IT TURNED OUT THE FIRST CLUES 

4479
03:02:26,640 --> 03:02:27,280
WERE PROVIDED IN THE 

4480
03:02:27,280 --> 03:02:29,440
SUPPLEMENTARY DATA SECTION OF 

4481
03:02:29,440 --> 03:02:29,800
THE PAPER.

4482
03:02:29,800 --> 03:02:31,640
THERE WAS A SECONDARY ANALYSIS 

4483
03:02:31,640 --> 03:02:35,040
AND BASICALLY FOUND THAT CLONAL 

4484
03:02:35,040 --> 03:02:38,160
HEMATOPOIESIS WAS ASSOCIATED 

4485
03:02:38,160 --> 03:02:39,440
WITH INCREASED CORONARY HEART 

4486
03:02:39,440 --> 03:02:41,000
DISEASE AND STROKE WHICH WAS BIG

4487
03:02:41,000 --> 03:02:43,120
CONSIDERING THE PREVALENCE IN 

4488
03:02:43,120 --> 03:02:43,480
THE POPULATION.

4489
03:02:43,480 --> 03:02:48,840
IT WAS A STRIKING FINDING AND 

4490
03:02:48,840 --> 03:02:50,520
PEOPLE DIDN'T REALLY PAY 

4491
03:02:50,520 --> 03:02:52,800
ATTENTION UNTIL THIS ASPECT.

4492
03:02:52,800 --> 03:02:54,520
PEOPLE PAID ATTENTION TO THE 

4493
03:02:54,520 --> 03:02:55,440
MORTALITY BUT NOT TO THE 

4494
03:02:55,440 --> 03:03:22,240
CARDIOVASCULAR DISEASE.

4495
03:03:22,240 --> 03:03:24,240
MANY STUDIES ASSOCIATED 

4496
03:03:24,240 --> 03:03:26,240
HEMATOPOIESIS WITH THE STUDY AND

4497
03:03:26,240 --> 03:03:27,280
WITH CARDIOVASCULAR DISEASE.

4498
03:03:27,280 --> 03:03:34,040
BURY  -- I WANT TO POINT OUT 

4499
03:03:34,040 --> 03:03:35,240
IT'S BEEN ASSOCIATED WITH 

4500
03:03:35,240 --> 03:03:37,880
CHRONIC KIDNEY DISEASE AND 

4501
03:03:37,880 --> 03:03:43,960
ACCELERATED AGING, OSTEOPOROSIS,

4502
03:03:43,960 --> 03:03:45,240
PREMATURE MENOPAUSE, DIABETES, 

4503
03:03:45,240 --> 03:03:45,520
ETCETERA.

4504
03:03:45,520 --> 03:03:52,800
WITH THE STUDIES IT'S 

4505
03:03:52,800 --> 03:03:54,240
EPIDEMIOLOGY AND WE DON'T KNOW 

4506
03:03:54,240 --> 03:03:55,240
WHAT'S CAUSAL AND DIRECTIONAL 

4507
03:03:55,240 --> 03:03:57,200
AND HAVE NO IDEA ABOUT 

4508
03:03:57,200 --> 03:03:57,480
MECHANISM.

4509
03:03:57,480 --> 03:04:00,320
IT COULD BE FOR EXAMPLE, AS WE 

4510
03:04:00,320 --> 03:04:03,440
AGE WE DEVELOP CLONAL 

4511
03:04:03,440 --> 03:04:04,560
HEMATOPOIESIS AND DEVELOP 

4512
03:04:04,560 --> 03:04:05,120
CARDIOVASCULAR DISEASE AND 

4513
03:04:05,120 --> 03:04:07,840
THEY'RE A PHENOMENON OF THE 

4514
03:04:07,840 --> 03:04:09,560
AGING PROCESS AND WE WANTED TO 

4515
03:04:09,560 --> 03:04:12,480
LOOK AT EXPERIMENTAL SYSTEMS AND

4516
03:04:12,480 --> 03:04:13,120
TEST WHETHER CLONAL 

4517
03:04:13,120 --> 03:04:15,080
HEMATOPOIESIS IS DIRECTLY 

4518
03:04:15,080 --> 03:04:16,640
UPSTREAM FROM CARDIOVASCULAR 

4519
03:04:16,640 --> 03:04:17,360
DISEASE.

4520
03:04:17,360 --> 03:04:18,440
WE BASICALLY BUILT MOUSE MODELS 

4521
03:04:18,440 --> 03:04:21,640
AND HAVE DONE THIS WITH A NUMBER

4522
03:04:21,640 --> 03:04:26,680
OF CLONAL HEMATOPOIESIS OR CHIP 

4523
03:04:26,680 --> 03:04:33,720
DRIVER GENES AND OTHERS AND WHAT

4524
03:04:33,720 --> 03:04:39,160
I'LL SHARE QUICKLY SOME OF THESE

4525
03:04:39,160 --> 03:04:53,440
EARLY DATA IN OUR FIRST WE DID A

4526
03:04:53,440 --> 03:04:55,240
BONE MARROW TRANSPLANT AND 

4527
03:04:55,240 --> 03:05:00,720
WANTED TO LOOK AT THE AMOUNT OF 

4528
03:05:00,720 --> 03:05:03,200
MUTANT HEMATOPOIETIC CELLS AND 

4529
03:05:03,200 --> 03:05:06,960
TAKE CELLS AND COMBINE THEM WITH

4530
03:05:06,960 --> 03:05:10,520
90% BONE MARROW CELLS IN 

4531
03:05:10,520 --> 03:05:13,120
RECIPIENT MICE IRRADIATED.

4532
03:05:13,120 --> 03:05:17,280
THE MICE THAT RECEIVED THE 

4533
03:05:17,280 --> 03:05:23,200
KNOCKOUT BONE MARROW CELLS WE 

4534
03:05:23,200 --> 03:05:24,360
COULD LABEL.

4535
03:05:24,360 --> 03:05:27,080
WILD TYPE STAYS AT 10% AND YOU 

4536
03:05:27,080 --> 03:05:50,320
SEE THEY INCREASED STRIKINGLY.

4537
03:05:50,320 --> 03:05:55,160
HAVE TO DO DNA SEQUENCING AND 

4538
03:05:55,160 --> 03:05:56,320
ONE FINDS AN AMPLIFICATION OF 

4539
03:05:56,320 --> 03:05:58,440
THE MUTANT DRIVER GENE AT THE 

4540
03:05:58,440 --> 03:05:59,240
EXPENSE OF WILD TYPE CELLS 

4541
03:05:59,240 --> 03:06:02,440
BECAUSE THE CELLS BASICALLY HAVE

4542
03:06:02,440 --> 03:06:08,560
A SELECTIVE ADVANTAGE AND THAT'S

4543
03:06:08,560 --> 03:06:09,720
CONSISTENT WITH THE CLINICAL 

4544
03:06:09,720 --> 03:06:11,240
PARADIGM OF CLONAL HEMATOPOIESIS

4545
03:06:11,240 --> 03:06:22,120
AND WHEN A MOUSE DEVELOPS HEART 

4546
03:06:22,120 --> 03:06:23,560
FAILURE THEY FIND THE CLONAL 

4547
03:06:23,560 --> 03:06:25,000
HEMATOPOIESIS WILL LEAD TO 

4548
03:06:25,000 --> 03:06:25,920
INCREASE IN CARDIOVASCULAR 

4549
03:06:25,920 --> 03:06:26,280
DISEASE.

4550
03:06:26,280 --> 03:06:29,760
WE'RE SEEING ABOUT A 60% 

4551
03:06:29,760 --> 03:06:33,480
INCREASE IN ATHEROSCLEROTIC 

4552
03:06:33,480 --> 03:06:37,040
PLAQUE SIZE PROVIDING THE FIRST 

4553
03:06:37,040 --> 03:06:37,560
EVIDENCE THAT CLONAL 

4554
03:06:37,560 --> 03:06:39,520
HEMATOPOIESIS COULD BE A DRIVER 

4555
03:06:39,520 --> 03:06:41,720
OF CARDIOVASCULAR DISEASE.

4556
03:06:41,720 --> 03:06:47,400
TO SUMMARIZE ALL THIS, THERE'S A

4557
03:06:47,400 --> 03:06:49,240
PREVALENT PRE-CANCEROUS STATE IN

4558
03:06:49,240 --> 03:06:55,680
THE BLOOD THAT PROMOTE S 

4559
03:06:55,680 --> 03:06:57,320
CARDIOVASCULAR DISEASE AND CELLS

4560
03:06:57,320 --> 03:06:59,560
WILL GET PEPPERED WITH 

4561
03:06:59,560 --> 03:07:02,600
MUTATIONS, WHEN THAT HAPPENS THE

4562
03:07:02,600 --> 03:07:05,160
SUBJECT WILL UNDER GO CLONAL 

4563
03:07:05,160 --> 03:07:06,840
HEMATOPOIESIS AND THAT'S UP 

4564
03:07:06,840 --> 03:07:09,440
STREAM OF ATHEROSCLEROSIS OUR 

4565
03:07:09,440 --> 03:07:10,880
HEART FAILURE OR OTHER DISEASES 

4566
03:07:10,880 --> 03:07:11,760
WE MODEL.

4567
03:07:11,760 --> 03:07:12,720
THE QUESTION IS WHAT'S THE 

4568
03:07:12,720 --> 03:07:14,360
MECHANISM AND IF WE UNDERSTAND 

4569
03:07:14,360 --> 03:07:17,160
THE MECHANISM WOULD THAT PROVIDE

4570
03:07:17,160 --> 03:07:21,000
NEW INSIGHTS ABOUT POTENTIAL 

4571
03:07:21,000 --> 03:07:22,240
THERAPIES?

4572
03:07:22,240 --> 03:07:23,560
IT TURNED OUT -- I ALWAYS 

4573
03:07:23,560 --> 03:07:25,400
THOUGHT IT WOULD IN MORE COMPLEX

4574
03:07:25,400 --> 03:07:27,960
BUT IT SEEMS THE PARADIGM IS 

4575
03:07:27,960 --> 03:07:28,600
DEVELOPING MANY DRIVER GENES 

4576
03:07:28,600 --> 03:07:31,200
SEEM TO BE WORKING THROUGH THE 

4577
03:07:31,200 --> 03:07:36,640
IL BETA, IL6 PATHWAY IN MYELOID 

4578
03:07:36,640 --> 03:07:39,120
CELLS AND THIS IS FIRST DATA AND

4579
03:07:39,120 --> 03:07:41,640
MORE ON THE BETA PRODUCTION AND 

4580
03:07:41,640 --> 03:07:45,440
TAKE CELLS THE MICE AND WHEN 

4581
03:07:45,440 --> 03:07:48,120
STIMULATED MAKE MORE IL6 AND CAN

4582
03:07:48,120 --> 03:07:54,240
SHOW IN EARLY STUDIES TO TAKE AN

4583
03:07:54,240 --> 03:07:55,800
INHIBITER BLOCK AND BASICALLY 

4584
03:07:55,800 --> 03:07:58,800
RESERVE THE PATHOLOGICAL 

4585
03:07:58,800 --> 03:08:01,640
PHENOTYPE CONFERRED BY THIS 

4586
03:08:01,640 --> 03:08:02,600
MODEL OF CLONAL HEMATOPOIESIS 

4587
03:08:02,600 --> 03:08:04,040
AND THERE'S CLINICAL EVIDENCE.

4588
03:08:04,040 --> 03:08:08,600
IF YOU LOOK AT THE TOP MED 

4589
03:08:08,600 --> 03:08:10,880
COHORT USING HEMATOPOIESIS IS 

4590
03:08:10,880 --> 03:08:14,880
ASSOCIATED WITH IL6 AND IL1 BETA

4591
03:08:14,880 --> 03:08:18,240
AND THERE WAS A STUDY IN THE 

4592
03:08:18,240 --> 03:08:22,200
U.K. DEMONSTRATING A COMMON IL6 

4593
03:08:22,200 --> 03:08:25,120
RECEPTOR POLYMORPHISM SERVING AS

4594
03:08:25,120 --> 03:08:27,960
A PROXY AND IN THOSE INDIVIDUALS

4595
03:08:27,960 --> 03:08:30,240
THAT HAVE CLONAL HEMATOPOIESIS 

4596
03:08:30,240 --> 03:08:32,640
IT ELIMINATES THE ASSOCIATION 

4597
03:08:32,640 --> 03:08:35,680
BETWEEN THAT CONDITION AND 

4598
03:08:35,680 --> 03:08:38,920
INCIDENT CARDIOVASCULAR DISEASE.

4599
03:08:38,920 --> 03:08:43,200
FINALLY IN THE CANTOS TRIAL 

4600
03:08:43,200 --> 03:08:44,640
TESTING A NEUTRALIZING ANTIBODY 

4601
03:08:44,640 --> 03:08:47,840
AND THE INDIVIDUALS ENROLLED IN 

4602
03:08:47,840 --> 03:08:53,000
THE TRIAL EXHIBITED A SUPERIOR 

4603
03:08:53,000 --> 03:08:54,000
RESPONSE AND IF YOU LOOK AT THE 

4604
03:08:54,000 --> 03:08:59,000
STUDY POPULATION THERE WAS A 15%

4605
03:08:59,000 --> 03:09:02,640
REDUCTION IN MAJOR 

4606
03:09:02,640 --> 03:09:04,640
CARDIOVASCULAR EVENTS BUT 

4607
03:09:04,640 --> 03:09:05,280
INDIVIDUALS WITH HEMATOPOIESIS 

4608
03:09:05,280 --> 03:09:07,840
THERE WAS A 60% REDUCTION 

4609
03:09:07,840 --> 03:09:12,560
SUGGESTING IF YOU EVALUATE AN 

4610
03:09:12,560 --> 03:09:14,640
INDIVIDUAL'S CLONAL 

4611
03:09:14,640 --> 03:09:15,240
HEMATOPOIESIS IT MAY PROVIDE 

4612
03:09:15,240 --> 03:09:18,480
PERSONALIZED INFORMATION OR FIND

4613
03:09:18,480 --> 03:09:20,400
PEOPLE TO BETTER RESPOND TO 

4614
03:09:20,400 --> 03:09:22,560
DISEASE PROCESS.

4615
03:09:22,560 --> 03:09:23,320
I HAVE 10 MINUTES.

4616
03:09:23,320 --> 03:09:26,480
LET ME TELL BUT ONE OF THE 

4617
03:09:26,480 --> 03:09:28,040
THINGS THAT BOTHERED ME SINCE 

4618
03:09:28,040 --> 03:09:31,240
THE BEGINNING ABOUT THE FIELD OR

4619
03:09:31,240 --> 03:09:34,680
SINCE 2017 WHEN THIS WAS 

4620
03:09:34,680 --> 03:09:35,240
PUBLISHED.

4621
03:09:35,240 --> 03:09:36,280
THE CHIP DRIVER GENES 

4622
03:09:36,280 --> 03:09:38,960
RECURRENTLY MUTATED IN CANCER 

4623
03:09:38,960 --> 03:09:40,160
PROBABLY ONLY ACCOUNT FOR THE 

4624
03:09:40,160 --> 03:09:41,640
MINORITY OF CLONAL EVENTS IN THE

4625
03:09:41,640 --> 03:09:43,240
BLOOD AND POINTED OUT WHEN THEY 

4626
03:09:43,240 --> 03:09:47,240
DID A NON-BIASSED WHOLE GENOME 

4627
03:09:47,240 --> 03:09:49,040
SEQUENCE ANALYSIS AND 13% OF THE

4628
03:09:49,040 --> 03:09:54,800
CLONAL EVENTS THEY COULD DETECT 

4629
03:09:54,800 --> 03:09:57,360
WERE ASSOCIATED WITH MUTATIONS 

4630
03:09:57,360 --> 03:09:59,240
IN KNOWN DRIVER GENES, YET THE 

4631
03:09:59,240 --> 03:10:14,680
BIG GROUP OF UNKNOWN HERE STILL 

4632
03:10:14,680 --> 03:10:17,240
EXHIBITED MORTALITY AND THIS IS 

4633
03:10:17,240 --> 03:10:19,080
THE FIRST DISCLOSURE AND OF A 

4634
03:10:19,080 --> 03:10:21,400
FUND STUDY AND BECAUSE IT'S AN 

4635
03:10:21,400 --> 03:10:24,360
NIA MEETING I THOUGHT IT WOULD 

4636
03:10:24,360 --> 03:10:26,680
BE APPROPRIATE BUT WE'RE 

4637
03:10:26,680 --> 03:10:32,680
RERESPONDING -- RESPONDING TO 

4638
03:10:32,680 --> 03:10:34,480
COMMENTS RIGHT NOW AND FEMALES 

4639
03:10:34,480 --> 03:10:40,240
81 YEARS AND MALES 76 YEARS 

4640
03:10:40,240 --> 03:10:41,160
FEMALES LIVING LONGER IS BAKED 

4641
03:10:41,160 --> 03:10:43,560
IN OUR CULTURE AND THERE'S MANY 

4642
03:10:43,560 --> 03:10:44,880
MEN IN THE UNITED STATES IT'S 

4643
03:10:44,880 --> 03:10:47,240
MANY MILLIONS OF YEARS OF LIFE 

4644
03:10:47,240 --> 03:10:47,840
LOST.

4645
03:10:47,840 --> 03:10:48,720
WE DON'T UNDERSTAND THIS.

4646
03:10:48,720 --> 03:10:52,040
MOST OF YOU PROBABLY ASSUME THAT

4647
03:10:52,040 --> 03:10:55,240
MEN WE HAVE TESTOSTERONE AND 

4648
03:10:55,240 --> 03:11:04,440
MAKES OUT -- US STUPID AND THE 

4649
03:11:04,440 --> 03:11:08,400
GENETIC COMPONENT MEN WILL LOSE 

4650
03:11:08,400 --> 03:11:10,640
THE Y CHROMOSOME.

4651
03:11:10,640 --> 03:11:18,240
IT'S THE GENE THAT CONFERS 

4652
03:11:18,240 --> 03:11:38,040
MALENESS AND IT'S THE MOST DIAG 

4653
03:11:38,040 --> 03:11:41,840
ZYGOTIC GENE AND MOST MEN LOSE 

4654
03:11:41,840 --> 03:11:44,680
THIS AND THERE'S A NUMBER OF 

4655
03:11:44,680 --> 03:11:47,240
SOMATIC MUTATIONS TO THE CHIP 

4656
03:11:47,240 --> 03:11:49,960
GENE SO IT'S A BIG DEAL ABOUT 

4657
03:11:49,960 --> 03:11:52,640
4.5 TIMES IF YOU LOOK AT MALES 

4658
03:11:52,640 --> 03:11:54,640
2.25 TIMES IF YOU LOOK AT 

4659
03:11:54,640 --> 03:11:55,240
FEMALES.

4660
03:11:55,240 --> 03:12:00,320
AND STRIKINGLY, MOSAIC LOSS OF Y

4661
03:12:00,320 --> 03:12:02,880
IS INCREASED IN CANCER MORTALITY

4662
03:12:02,880 --> 03:12:04,280
AND DIAGNOSIS OF ALZHEIMER'S 

4663
03:12:04,280 --> 03:12:04,520
DISEASE.

4664
03:12:04,520 --> 03:12:07,520
OUR COLLABORATOR IN THIS STUDY 

4665
03:12:07,520 --> 03:12:12,640
MADE THIS FIRST ASSOCIATION WITH

4666
03:12:12,640 --> 03:12:17,040
MORTALITY WAS QUOTED AS SAYING 

4667
03:12:17,040 --> 03:12:19,280
IT SPEAKS TO THE LOSS OF 

4668
03:12:19,280 --> 03:12:24,120
MORTALITY FOR MEN COMPARED TO 

4669
03:12:24,120 --> 03:12:24,680
WOMEN.

4670
03:12:24,680 --> 03:12:25,720
IT'S A SMALL CHROMOSOME AND 

4671
03:12:25,720 --> 03:12:28,240
CHARACTERIZED AS A GENETIC WASTE

4672
03:12:28,240 --> 03:12:30,640
LAND AND HAS 71 GENES AND MANY 

4673
03:12:30,640 --> 03:12:33,840
ARE DUPLICATED SO ONLY ENCODES 

4674
03:12:33,840 --> 03:12:42,720
FOR 27 UNIQUE PROTEINS AND 9 ARE

4675
03:12:42,720 --> 03:12:44,240
UBIQUITOUS AND IT COMES DOWN TO 

4676
03:12:44,240 --> 03:12:46,280
THE SAME QUESTION AS WITH CHIP, 

4677
03:12:46,280 --> 03:12:50,680
IS MOSAIC LOSS OF Y CAUSALLY 

4678
03:12:50,680 --> 03:12:55,960
ASSOCIATED WITH MORBIDITY AND 

4679
03:12:55,960 --> 03:12:57,640
MORTALITY AND NO STUDIES HAVE 

4680
03:12:57,640 --> 03:13:01,040
ADDRESSED THIS.

4681
03:13:01,040 --> 03:13:05,040
WE CREATED A MODEL OF MOSAIC 

4682
03:13:05,040 --> 03:13:06,880
LOSS OF Y AND WE TOOK BONE 

4683
03:13:06,880 --> 03:13:09,040
MARROW CELLS AND INFECT THEM 

4684
03:13:09,040 --> 03:13:14,720
WITH A VIRUS THAT EXPRESSES A 

4685
03:13:14,720 --> 03:13:18,720
GUIDE RNA THAT TARGETS THE Y 

4686
03:13:18,720 --> 03:13:21,280
CHROMOSOME AND EFFECTIVE AT 

4687
03:13:21,280 --> 03:13:22,680
ELIMINATING THE Y CHROMOSOME.

4688
03:13:22,680 --> 03:13:26,600
WE CAN ELIMINATE WITH OUR BEST 

4689
03:13:26,600 --> 03:13:28,400
GUIDE RNA 90% OF THE Y 

4690
03:13:28,400 --> 03:13:29,040
CHROMOSOME.

4691
03:13:29,040 --> 03:13:31,240
HERE YOU SEE IN THE FISH 

4692
03:13:31,240 --> 03:13:34,360
ANALYSIS THE Y CHROMOSOME IS 

4693
03:13:34,360 --> 03:13:36,080
GONE AND IF YOU LOOK AT THE 

4694
03:13:36,080 --> 03:13:39,040
CELLS LABELLED WITH THE VIRUS 

4695
03:13:39,040 --> 03:13:43,240
GFP YOU CAN SEE IF YOU LOOK AT Y

4696
03:13:43,240 --> 03:13:46,560
EXPRESSED GENES, WHY CHROMOSOME 

4697
03:13:46,560 --> 03:13:47,640
EXPRESSED GENES IN BLOOD CELLS 

4698
03:13:47,640 --> 03:13:50,480
IT KNOCKS DOWN THE DETECTABLE 

4699
03:13:50,480 --> 03:13:56,960
EXPRESSION OF THESE GENES.

4700
03:13:56,960 --> 03:14:00,400
WE DID THIS BONE MARROW 

4701
03:14:00,400 --> 03:14:02,600
TRANSPLANTATION AND SAID WHAT DO

4702
03:14:02,600 --> 03:14:04,480
WE DO WITH THE MICE.

4703
03:14:04,480 --> 03:14:07,240
THEY SHARE FEATURED WITH MEN AND

4704
03:14:07,240 --> 03:14:10,600
THIS IS DONE IN MALE MICE.

4705
03:14:10,600 --> 03:14:12,880
THEY EXHIBITED DIMINISHED 

4706
03:14:12,880 --> 03:14:16,760
SURVIVAL AND DEVELOPED AN AGE 

4707
03:14:16,760 --> 03:14:20,040
RELATED CARDIO MYOPATHY.

4708
03:14:20,040 --> 03:14:22,480
THEY HAD MORE PULMONARY AND 

4709
03:14:22,480 --> 03:14:26,400
RENAL FIBROSIS AND COULD DETECT 

4710
03:14:26,400 --> 03:14:28,280
A COGNITIVE DECLINE.

4711
03:14:28,280 --> 03:14:31,240
THIS IS INTERESTING.

4712
03:14:31,240 --> 03:14:37,200
WITH THAT DATA WE WENT TO QUERY 

4713
03:14:37,200 --> 03:14:39,280
THE BIOBANK BECAUSE THERE WASN'T

4714
03:14:39,280 --> 03:14:43,000
GOOD PROSPECTIVE DATA TO SUGGEST

4715
03:14:43,000 --> 03:14:48,080
MOSAIC LOSS OF Y WAS RELATED TO 

4716
03:14:48,080 --> 03:14:50,240
CARDIOVASCULAR DISEASE MORTALITY

4717
03:14:50,240 --> 03:14:53,480
AND FOUND A DOSE RESPONSE 

4718
03:14:53,480 --> 03:14:56,280
RELATIONSHIP WITH DISEASES OF 

4719
03:14:56,280 --> 03:14:58,800
THE CIRCULATORY SYSTEM AND MEN 

4720
03:14:58,800 --> 03:15:03,320
WHO LOST MORE OF THEIR Y 

4721
03:15:03,320 --> 03:15:06,720
CHROMOSOME EXHIBITED MORE 

4722
03:15:06,720 --> 03:15:08,600
CARDIOVASCULAR DISEASE AND 

4723
03:15:08,600 --> 03:15:12,240
HYPERTENSIVE HEART DISEASE AND 

4724
03:15:12,240 --> 03:15:12,520
WHATEVER.

4725
03:15:12,520 --> 03:15:13,680
WE BECAME INTERESTED IN THE 

4726
03:15:13,680 --> 03:15:14,720
HEART FAILURE PHENOTYPE.

4727
03:15:14,720 --> 03:15:18,160
THIS IS WHAT THE DATA LOOKS LIKE

4728
03:15:18,160 --> 03:15:21,560
IF YOU LOOK AT THE SNIPS.

4729
03:15:21,560 --> 03:15:28,080
HERE'S THE XY AND AS MEN LOSE 

4730
03:15:28,080 --> 03:15:29,840
THE Y CHROMOSOME THIS COULD BE 

4731
03:15:29,840 --> 03:15:32,680
TURNER SYNDROME INTERESTINGLY 

4732
03:15:32,680 --> 03:15:35,640
YOU HAVE PEOPLE SELF-IDENTIFIED 

4733
03:15:35,640 --> 03:15:39,600
AS MALES AND INDIVIDUALS WITH 

4734
03:15:39,600 --> 03:15:42,360
XYY AND MEN WHO HAVE TWO Y 

4735
03:15:42,360 --> 03:15:50,680
CHROMOSOMES AND XYY.

4736
03:15:50,680 --> 03:15:52,560
BASICALLY INSTEAD OF CONTINUING 

4737
03:15:52,560 --> 03:15:54,440
TO DO THE AGING EXPERIMENTS WE 

4738
03:15:54,440 --> 03:15:58,840
ALSO CREATED AN ACUTE MODEL OF 

4739
03:15:58,840 --> 03:16:02,400
NON ISCHEMIC HEART MODEL WIN 

4740
03:16:02,400 --> 03:16:08,600
TRANS VERSION AORTIC 

4741
03:16:08,600 --> 03:16:10,040
CONSTRICTION AND ACERBATED WHEN 

4742
03:16:10,040 --> 03:16:11,840
THE MICE HAVE BEEN ENGINEERED TO

4743
03:16:11,840 --> 03:16:14,640
HAVE MOSAIC LOSS OF Y AND 

4744
03:16:14,640 --> 03:16:17,320
THERE'S AGAIN MORE OF THIS 

4745
03:16:17,320 --> 03:16:19,240
FIBROSIS AND INCREASE IN 

4746
03:16:19,240 --> 03:16:22,560
FIBROTIC AREA.

4747
03:16:22,560 --> 03:16:25,680
IF YOU DO RNA SEQ ANALYSIS 

4748
03:16:25,680 --> 03:16:29,240
THERE'S AN INCREASE OF TGA BETA 

4749
03:16:29,240 --> 03:16:30,400
SIGNALLING IN THE MYELOID CELLS 

4750
03:16:30,400 --> 03:16:32,680
AND THIS IS STRIKING AND TOOK A 

4751
03:16:32,680 --> 03:16:34,840
WHILE TO FIGURE OUT THERE'S IN 

4752
03:16:34,840 --> 03:16:36,920
INCREASE IN INFLAMMATION IN THE 

4753
03:16:36,920 --> 03:16:37,120
MICE.

4754
03:16:37,120 --> 03:16:39,360
WE'RE GOOD AT LOOKING AT 

4755
03:16:39,360 --> 03:16:40,760
INFLAMMATION AND COULDN'T FIND 

4756
03:16:40,760 --> 03:16:41,240
IT.

4757
03:16:41,240 --> 03:16:43,040
WE THOUGHT Y CHROMOSOME WOULD BE

4758
03:16:43,040 --> 03:16:44,640
LIKE CHIP AND IT'S NOT.

4759
03:16:44,640 --> 03:16:46,840
IT'S BASICALLY PROMOTING 

4760
03:16:46,840 --> 03:16:47,120
FIBROSIS.

4761
03:16:47,120 --> 03:16:49,320
FINALLY, WE WERE ABLE TO SHOW 

4762
03:16:49,320 --> 03:16:52,120
THE TGF BETA NEUTRALIZATION WITH

4763
03:16:52,120 --> 03:16:54,840
A BLOCKING ANTIBODY CAN REVERSE 

4764
03:16:54,840 --> 03:16:57,040
THE ALSO OF THE WILD TYPE IN THE

4765
03:16:57,040 --> 03:16:57,520
HEART.

4766
03:16:57,520 --> 03:17:02,640
TO ESSENTIALLY WRAP THIS UP 

4767
03:17:02,640 --> 03:17:06,200
HERE, ORGAN FIBROSIS INCREASES 

4768
03:17:06,200 --> 03:17:07,880
WIN AGE AND CONTRIBUTE TO 45% OF

4769
03:17:07,880 --> 03:17:09,480
LESS IN INDUSTRIALIZED COUNTRIES

4770
03:17:09,480 --> 03:17:12,200
AND ASSOCIATED WITH MORBIDITY 

4771
03:17:12,200 --> 03:17:17,440
AND MORTALITY.

4772
03:17:17,440 --> 03:17:31,000
WE CONSTRUCTED A Y PROMOTES TGF 

4773
03:17:31,000 --> 03:17:31,520
BETA SIGNALLING.

4774
03:17:31,520 --> 03:17:32,360
THANK YOU AND I FINISHED ONE 

4775
03:17:32,360 --> 03:17:53,160
MINUTE EARLYMINUTE EARLYMINUTE
EARLYYMINUT
E EARLYMINUTE EARLY.

4776
03:17:53,160 --> 03:17:57,640
>> I WONDER ABOUT THE COMPARISON

4777
03:17:57,640 --> 03:18:02,080
ON THE GENES ON THE MOUSE AND IF

4778
03:18:02,080 --> 03:18:06,040
THAT GIVES YOU INSIGHT TO THE 

4779
03:18:06,040 --> 03:18:07,640
HUMAN Y CHROMOSOME.

4780
03:18:07,640 --> 03:18:08,880
IF THERE'S TIME I'LL ASK ANOTHER

4781
03:18:08,880 --> 03:18:09,480
QUESTION TOO.

4782
03:18:09,480 --> 03:18:10,040
>> THAT'S RIGHT.

4783
03:18:10,040 --> 03:18:14,360
SO WE CAN RULE OUT A FEW, RIGHT?

4784
03:18:14,360 --> 03:18:16,360
SO IT'S AN IMPERFECT ANALYSIS 

4785
03:18:16,360 --> 03:18:17,920
BECAUSE LIKE MAYBE THERE'S 

4786
03:18:17,920 --> 03:18:19,240
SOMETHING BEING LOST ON THE 

4787
03:18:19,240 --> 03:18:22,440
HUMAN Y CHROMOSOME WE CANNOT 

4788
03:18:22,440 --> 03:18:23,640
REPLICATE OR FIND IN A MOUSE.

4789
03:18:23,640 --> 03:18:26,240
BUT WE TAKE THAT SHORT LIST OF 

4790
03:18:26,240 --> 03:18:26,440
GENES.

4791
03:18:26,440 --> 03:18:27,920
THAT'S WHAT WE'RE DOING RIGHT 

4792
03:18:27,920 --> 03:18:31,880
NOW USING THE CRISPR TO GO OUT 

4793
03:18:31,880 --> 03:18:38,320
AND TARGET THE INDIVIDUAL CODING

4794
03:18:38,320 --> 03:18:39,960
LOCI AND BECAUSE WE KNOW THIS IS

4795
03:18:39,960 --> 03:18:42,080
AN IMMUNE EFFECT WE'RE LOOKING 

4796
03:18:42,080 --> 03:18:46,240
AT Y CHROMOSOME GENES EXPRESSED 

4797
03:18:46,240 --> 03:18:47,640
IN THE HEMATOPOIETIC SYSTEM TO 

4798
03:18:47,640 --> 03:18:49,040
NARROW IT DOWN FURTHER.

4799
03:18:49,040 --> 03:18:50,480
IT'S NO SO MAYBE HARD TO FIND 

4800
03:18:50,480 --> 03:18:54,720
WHAT THE GONE MIGHT BE.

4801
03:18:54,720 --> 03:18:55,000
WE'LL SEE.

4802
03:18:55,000 --> 03:18:56,640
THANK YOU FOR THE QUESTION.

4803
03:18:56,640 --> 03:18:59,120
>> RICHARD AND THEN FRANK AND 

4804
03:18:59,120 --> 03:19:05,080
MAYBE THEN WE CAN CIRCLE BACK TO

4805
03:19:05,080 --> 03:19:05,640
PEGGY.

4806
03:19:05,640 --> 03:19:08,640
>> WHEN YOU DESCRIBED THE U.K. 

4807
03:19:08,640 --> 03:19:10,800
BIOBANK  THE CORRELATION OF LOSS

4808
03:19:10,800 --> 03:19:12,600
OF Y WITH CARDIOVASCULAR 

4809
03:19:12,600 --> 03:19:14,680
DISEASE, A PRESUME THAT WAS NOT 

4810
03:19:14,680 --> 03:19:19,240
THE CORRELATION WITH AGE?

4811
03:19:19,240 --> 03:19:23,960
>> THE EPIDEMIOLOGY WAS DONE BY 

4812
03:19:23,960 --> 03:19:28,480
LARS FORSBERG AND I THINK HE 

4813
03:19:28,480 --> 03:19:31,240
TOOK IT INTO ACCOUNT WHEN HE WAS

4814
03:19:31,240 --> 03:19:32,200
DOING HIS ANALYSIS.

4815
03:19:32,200 --> 03:19:34,720
THE CONFOUNDERS.

4816
03:19:34,720 --> 03:19:36,560
WE DIDN'T DO THAT ASPECT.

4817
03:19:36,560 --> 03:19:41,960
WE GAVE IT TO THE EXPERTS.

4818
03:19:41,960 --> 03:19:42,440
GOOD POINT 

4819
03:19:42,440 --> 03:19:43,840
>> FRANK.

4820
03:19:43,840 --> 03:19:45,360
KEN, IMPRESSIVE WORK.

4821
03:19:45,360 --> 03:19:47,400
I WAS WONDERING, AS YOU LOOK AT 

4822
03:19:47,400 --> 03:19:50,240
YOUR MODELS SAY THE CLONAL 

4823
03:19:50,240 --> 03:19:52,440
HEMATOPOIESIS MANIPULATION AND 

4824
03:19:52,440 --> 03:19:55,040
SEE THESE CYTOKINE AND IMMUNE 

4825
03:19:55,040 --> 03:19:57,440
CHANGES, WHAT IS YOUR STRATEGY 

4826
03:19:57,440 --> 03:19:59,760
THEN FOR COMPARING THEM TO THE 

4827
03:19:59,760 --> 03:20:03,440
MODELS OF AGING AND I'M BIAS BY 

4828
03:20:03,440 --> 03:20:05,840
FOLLOWING THE WORK HERE AT 

4829
03:20:05,840 --> 03:20:07,200
STANFORD AND WATCHING THE IMMUNE

4830
03:20:07,200 --> 03:20:09,680
CHANGES WITH AGING AND THERE'S 

4831
03:20:09,680 --> 03:20:12,080
SO MANY WAYS TO LOOK AT THAT 

4832
03:20:12,080 --> 03:20:20,680
WITH LARGE-SCALE DATA AND RNA 

4833
03:20:20,680 --> 03:20:21,080
SEQ.

4834
03:20:21,080 --> 03:20:22,480
>> NOT AS MUCH AS WE SHOULD.

4835
03:20:22,480 --> 03:20:26,720
IT'S A NEW FIELD AND WE'RE ALL 

4836
03:20:26,720 --> 03:20:30,880
KIND OF RUSHING TO FIND WHAT ARE

4837
03:20:30,880 --> 03:20:33,160
THE MAJOR SIGNALS AND MECHANISM.

4838
03:20:33,160 --> 03:20:34,360
TYPICALLY WE TAKE A YOUNG MOUSE 

4839
03:20:34,360 --> 03:20:38,280
AND FORCE A DISEASE ON IT IN A 

4840
03:20:38,280 --> 03:20:39,240
CLONAL HEMATOPOIESIS MODEL AND I

4841
03:20:39,240 --> 03:20:42,120
THINK IT WOULD BE GOOD TO 

4842
03:20:42,120 --> 03:20:42,840
COMPARE SOME OF THE CLONAL 

4843
03:20:42,840 --> 03:20:44,280
HEMATOPOIESIS WITH SOME OF THE 

4844
03:20:44,280 --> 03:20:50,480
MORE STANDARD MODELS OF AGING.

4845
03:20:50,480 --> 03:20:53,040
A COUPLE TIMES WE'VE DONE 

4846
03:20:53,040 --> 03:20:57,600
EXTENSIVE MODELLING AND GOT 

4847
03:20:57,600 --> 03:20:58,360
ANOTHER MODEL OF CLONAL 

4848
03:20:58,360 --> 03:21:00,600
HEMATOPOIESIS WHERE WE DON'T 

4849
03:21:00,600 --> 03:21:02,440
IRRADIATE A MOUSE AND LET THE 

4850
03:21:02,440 --> 03:21:04,440
MOUSE LIVE TO 15 TO 18 MONTHS 

4851
03:21:04,440 --> 03:21:07,240
AND FIND THEY BASICALLY ALSO 

4852
03:21:07,240 --> 03:21:09,240
EXHIBIT WHAT APPEARS TO BE 

4853
03:21:09,240 --> 03:21:09,920
ACCELERATED AGING TO THE EXTENT 

4854
03:21:09,920 --> 03:21:12,960
IT'S BEEN LOOKED AT.

4855
03:21:12,960 --> 03:21:19,440
WE SEE MORE AGE-RELATED CARDIO 

4856
03:21:19,440 --> 03:21:21,960
MYOPATHY AND BECOME 

4857
03:21:21,960 --> 03:21:22,680
METABOLICALLY DYSFUNCTIONAL AND 

4858
03:21:22,680 --> 03:21:22,960
INFLAMED.

4859
03:21:22,960 --> 03:21:24,840
>> WE HAVE SO MANY WAYS OF 

4860
03:21:24,840 --> 03:21:25,400
MEASURING AGE.

4861
03:21:25,400 --> 03:21:31,240
LOOK FOR WARD TO SEEING THAT, 

4862
03:21:31,240 --> 03:21:31,880
THANK YOU.

4863
03:21:31,880 --> 03:21:36,200
>> THAT WAS A FABULOUS TALK 

4864
03:21:36,200 --> 03:21:37,440
EXTREMELY INTERESTING.

4865
03:21:37,440 --> 03:21:39,200
FROM A GRAIN STANDPOINT, YOU 

4866
03:21:39,200 --> 03:21:42,040
SAID THE MOUSE MODEL DID SHOW 

4867
03:21:42,040 --> 03:21:44,600
COGNITIVE DECLINE WITH THE 

4868
03:21:44,600 --> 03:21:46,240
MOSAIC LOSS OF Y.

4869
03:21:46,240 --> 03:21:47,840
GIVEN YOU'RE SPEAKING OF 

4870
03:21:47,840 --> 03:21:50,680
FIBROSIS, WHAT DO YOU THINK THE 

4871
03:21:50,680 --> 03:21:54,800
MECHANISM IS FOR THE LOSS OF 

4872
03:21:54,800 --> 03:21:56,120
COGNITIVE FUNCTION GIVEN THE 

4873
03:21:56,120 --> 03:21:57,440
BRAIN DOESN'T HAVE FIBROSIS.

4874
03:21:57,440 --> 03:22:02,040
>> YEAH, I FL KNOW, I DON'T
KNOW.

4875
03:22:02,040 --> 03:22:03,640
I'M LUCKY TO HAVE A GOOD STROKE 

4876
03:22:03,640 --> 03:22:06,440
INVESTIGATOR IN MY LABORATORY 

4877
03:22:06,440 --> 03:22:07,240
AND SHE'S INTERESTED IN A LOT OF

4878
03:22:07,240 --> 03:22:09,160
THESE TYPES OF ISSUES AND SHE'S 

4879
03:22:09,160 --> 03:22:12,040
BEEN BASICALLY DOING THE STROKE 

4880
03:22:12,040 --> 03:22:14,200
MODELS WHICH ARE HARD FOR CLONAL

4881
03:22:14,200 --> 03:22:14,840
HEMATOPOIESIS BECAUSE YOU SET 

4882
03:22:14,840 --> 03:22:16,920
OFF A BOMB IN THE BRAIN AND THE 

4883
03:22:16,920 --> 03:22:19,120
IDEA YOU'LL SEE AN AFFECT IS 

4884
03:22:19,120 --> 03:22:19,560
TOUGH.

4885
03:22:19,560 --> 03:22:21,880
SHE'S THE ONE THAT SET UP THE 

4886
03:22:21,880 --> 03:22:23,280
MODELS BUT WE FOUND THIS 

4887
03:22:23,280 --> 03:22:24,560
COGNITIVE DECLINE AND WANTS TO 

4888
03:22:24,560 --> 03:22:25,840
INVESTIGATE THAT FURTHER.

4889
03:22:25,840 --> 03:22:27,080
NOW THAT WE'VE ESTABLISHED THIS 

4890
03:22:27,080 --> 03:22:29,080
MODEL WE CAN LOOK AT A LOT OF 

4891
03:22:29,080 --> 03:22:29,840
DIFFERENT DISEASE PROCESSES.

4892
03:22:29,840 --> 03:22:32,040
I AGREE, THERE'S NO LITERATURE 

4893
03:22:32,040 --> 03:22:34,800
OUT THERE ON FIBROSIS AND 

4894
03:22:34,800 --> 03:22:39,800
COGNITIVE DECLINE.

4895
03:22:39,800 --> 03:22:43,160
I DON'T KNOW.

4896
03:22:43,160 --> 03:22:45,040
YOU LET A MOUSE AGE AND WE SEE A

4897
03:22:45,040 --> 03:22:48,440
LOT OF THING AND WE CLEAVED OUT 

4898
03:22:48,440 --> 03:22:49,720
THE HEART FAILURE AND TAKE IT 

4899
03:22:49,720 --> 03:22:55,640
INTO WHAT WE DO HERE, BASICALLY.

4900
03:22:55,640 --> 03:22:57,640
>> AND I THINK FINAL QUESTION, 

4901
03:22:57,640 --> 03:23:01,320
PEGGY, DO YOU WANT TO CIRCLE 

4902
03:23:01,320 --> 03:23:01,520
BACK?

4903
03:23:01,520 --> 03:23:04,040
>> THAT WOULD BE GREAT, THANK 

4904
03:23:04,040 --> 03:23:04,200
YOU.

4905
03:23:04,200 --> 03:23:08,600
SO YOUR WORK WITH THE TET 2 AND 

4906
03:23:08,600 --> 03:23:11,480
IL6 AND IL BETA IS WONDERFUL AND

4907
03:23:11,480 --> 03:23:20,160
SET THE STANDARD FOR THE FIELD.

4908
03:23:20,160 --> 03:23:24,600
THERE'S ABOUT 20 GENES THAT PLAY

4909
03:23:24,600 --> 03:23:26,240
A ROLE IN CLONAL HEMATOPOIESIS 

4910
03:23:26,240 --> 03:23:28,440
AND TO WHAT PARADIGM A DO YOU 

4911
03:23:28,440 --> 03:23:30,960
THINK IT WILL FULFILL THE OTHER 

4912
03:23:30,960 --> 03:23:34,240
GENES AND B, BE RELEVANT FOR OWE

4913
03:23:34,240 --> 03:23:35,840
OTHER DISEASE PROCESSES THAT 

4914
03:23:35,840 --> 03:23:41,120
HAVEN'T BEEN STUDIED YET.

4915
03:23:41,120 --> 03:23:43,240
>> I THOUGHT, PEGGY, WHEN ALL 

4916
03:23:43,240 --> 03:23:44,160
THE GENES WORKED THROUGH 

4917
03:23:44,160 --> 03:23:45,320
DIFFERENT TYPES OF MECHANISMS 

4918
03:23:45,320 --> 03:23:50,320
THEY'RE ALL GOING TO BE WORKING 

4919
03:23:50,320 --> 03:23:52,160
THROUGH A DIFFERENT PATHWAY AND 

4920
03:23:52,160 --> 03:23:54,560
DIDN'T HAVE TO BE A 

4921
03:23:54,560 --> 03:23:56,040
PRO-INFLAMMATORY PATHWAY BUT WE 

4922
03:23:56,040 --> 03:24:01,080
LOOKED AT FOUR OR FIVE GENES AND

4923
03:24:01,080 --> 03:24:04,280
SEE AN IL1 BETA AND AS YOU CAN 

4924
03:24:04,280 --> 03:24:05,480
APPRECIATE PEOPLE THINK MAYBE 

4925
03:24:05,480 --> 03:24:08,760
ONE OF THE THINGS THAT LEADS ONE

4926
03:24:08,760 --> 03:24:10,600
OF THE INTRINSIC FACTORS THAT'S 

4927
03:24:10,600 --> 03:24:14,680
OCCURRING IN THE BONE MAYOREE 

4928
03:24:14,680 --> 03:24:18,840
THAT -- MARROW TO EXPAND IS LIKE

4929
03:24:18,840 --> 03:24:21,160
A FEEDBACK MECHANISM AND MAYBE 

4930
03:24:21,160 --> 03:24:23,240
YOU CAN EXPLAINING IT BETTER 

4931
03:24:23,240 --> 03:24:27,240
THAN I CAN TO THE AUDIENCE, AS 

4932
03:24:27,240 --> 03:24:29,640
WE AGE THE BONE MARROW BECOMES 

4933
03:24:29,640 --> 03:24:34,040
MORE INFLAMED AND CREATES A 

4934
03:24:34,040 --> 03:24:34,680
SELECTIVE DISADVANTAGE FOR THE 

4935
03:24:34,680 --> 03:24:36,240
WILD TYPE HEMATOPOIETIC CELLS 

4936
03:24:36,240 --> 03:24:37,640
AND THE CELLS WITH MUTATIONS AN 

4937
03:24:37,640 --> 03:24:40,600
DRIVER GENES ARE PROTECTED FROM 

4938
03:24:40,600 --> 03:24:41,560
THE CHRONIC INFLAMMATORY STATE 

4939
03:24:41,560 --> 03:24:43,440
AND IT'S A FEEDBACK TYPE OF A 

4940
03:24:43,440 --> 03:24:43,640
THING.

4941
03:24:43,640 --> 03:24:45,000
THAT'S POPULAR.

4942
03:24:45,000 --> 03:24:48,000
THERE'S BEEN RELATIVELY FEW 

4943
03:24:48,000 --> 03:24:50,560
STUDIES THAT LOOKED AT AND I'M 

4944
03:24:50,560 --> 03:24:53,840
SURE PEGGY KNOWS THIS, EVERYBODY

4945
03:24:53,840 --> 03:24:56,680
HAS SMALL TINY MUTATIONS WHEN 

4946
03:24:56,680 --> 03:24:58,360
WE'RE YOUNG WE ALREADY DEVELOPED

4947
03:24:58,360 --> 03:24:59,880
A LOT OF THEM BUT THEY GROW IN 

4948
03:24:59,880 --> 03:25:01,360
SOME PEOPLE AND NOT IN OTHERS 

4949
03:25:01,360 --> 03:25:03,880
AND THAT'S ANOTHER CHALLENGE OUT

4950
03:25:03,880 --> 03:25:04,960
THERE TO TRY TO UNDERSTAND 

4951
03:25:04,960 --> 03:25:07,040
WHAT'S GOING ON IN THE 

4952
03:25:07,040 --> 03:25:09,840
ENVIRONMENT OF THE HEMATOPOIETIC

4953
03:25:09,840 --> 03:25:12,280
STEM CELL ALLOWING THE MUTANT 

4954
03:25:12,280 --> 03:25:17,240
CLONES TO SUDDENLY HAVE THE 

4955
03:25:17,240 --> 03:25:19,240
ADVANTAGE.

4956
03:25:19,240 --> 03:25:20,280
>> GREAT.

4957
03:25:20,280 --> 03:25:21,440
THANK YOU VERY MUCH.

4958
03:25:21,440 --> 03:25:23,000
AGAIN, I JUST WANT TO THANK YOU,

4959
03:25:23,000 --> 03:25:26,600
DR. WALSH FOR YOUR REALLY 

4960
03:25:26,600 --> 03:25:29,800
EXCITING TALK AND SHARING WITH 

4961
03:25:29,800 --> 03:25:30,800
US THE CURRENT DATA.

4962
03:25:30,800 --> 03:25:34,360
AND WISH YOU ALL THE BEST SO 

4963
03:25:34,360 --> 03:25:34,840
THANK YOU VERY MUCH.

4964
03:25:34,840 --> 03:25:38,680
AND I THINK AT THIS POINT WE 

4965
03:25:38,680 --> 03:25:41,200
HAVE ONE MORE SECTION LEFT IN 

4966
03:25:41,200 --> 03:25:42,320
OUR OPEN SESSION.

4967
03:25:42,320 --> 03:25:44,440
FIRST, I THINK WE'LL TAKE A 

4968
03:25:44,440 --> 03:25:48,120
SHORT BREAK AGAIN.

4969
03:25:48,120 --> 03:25:49,120
SINCE WE'RE RUNNING A LITTLE BIT

4970
03:25:49,120 --> 03:25:51,000
LATE I THINK WE'LL JUST TAKE A 

4971
03:25:51,000 --> 03:25:53,520
10-MINUTE BREAK AND THEN 

4972
03:25:53,520 --> 03:25:55,240
RECONVENE TO HEAR FROM OUR 

4973
03:25:55,240 --> 03:25:58,640
INTRAMURAL PROGRAM.

4974
03:25:58,640 --> 03:26:02,040
SO IT IS NOW 1:31, SO LET'S TAKE

4975
03:26:02,040 --> 03:26:06,120
TO 1:40 AND WE'LL COME BACK IN A

4976
03:26:06,120 --> 03:26:07,320
SHORT TIME, 10 MINUTES.

4977
03:26:07,320 --> 03:26:11,720
LATE JUST BREAK FOR 10 MINUTES.

4978
03:26:11,720 --> 03:26:12,160
1:42 WE'LL RETURN.

4979
03:26:12,160 --> 03:26:21,600
THANKS VERY MUCH.

4980
03:26:21,600 --> 03:26:23,320
NEXT UP WE'LL HEAR FROM 

4981
03:26:23,320 --> 03:26:25,200
DR. LUIGI FERRUCCI FIRST 

4982
03:26:25,200 --> 03:26:26,560
REGARDING OUR INTRAMURAL PROGRAM

4983
03:26:26,560 --> 03:26:26,800
REPORT.

4984
03:26:26,800 --> 03:26:32,880
I'LL TURN IT OVER TO LUIGI AND 

4985
03:26:32,880 --> 03:26:34,280
HIS COLLEAGUES.

4986
03:26:34,280 --> 03:26:39,000
>> IT'S MY PLEASURE TO PRESENT 

4987
03:26:39,000 --> 03:26:41,040
SOMETHING ABOUT THE INTRAMURAL 

4988
03:26:41,040 --> 03:26:43,360
PROGRAM AT NIA AND OUR 

4989
03:26:43,360 --> 03:26:44,960
PRESENTATION WILL BE DIVIDED IN 

4990
03:26:44,960 --> 03:26:46,400
TWO PARTS.

4991
03:26:46,400 --> 03:26:48,760
THE FIRST PART IS OPEN TO THE 

4992
03:26:48,760 --> 03:26:53,320
PUBLIC AND WE'LL HAVE SOME OF MY

4993
03:26:53,320 --> 03:26:54,320
COLLEAGUES TO PRESENT THEIR 

4994
03:26:54,320 --> 03:26:56,560
SCIENCE, IN PARTICULAR, I'LL 

4995
03:26:56,560 --> 03:27:03,600
HAVE SUSAN RESNICK FROM THE 

4996
03:27:03,600 --> 03:27:07,160
LABORATORY OF NEUROSCIENCE 

4997
03:27:07,160 --> 03:27:09,000
PRESENTING AND THEN FROM THE 

4998
03:27:09,000 --> 03:27:14,120
POPULATION SCIENCE LABORATORY 

4999
03:27:14,120 --> 03:27:16,680
AND THE GERONTOLOGY BRANCH.

5000
03:27:16,680 --> 03:27:24,400
THEY'LL PRESENT A HIGHLIGHT S S
OF 

5001
03:27:24,400 --> 03:27:25,920
THE GROUP OF THE SCIENCE THEY'RE

5002
03:27:25,920 --> 03:27:27,800
DOING AND IN THE CLOSED SESSION 

5003
03:27:27,800 --> 03:27:34,440
I'LL TELL YOU MORE ABOUT THE 

5004
03:27:34,440 --> 03:27:38,280
MORE SALIENT EVENT AND AS WE SAW

5005
03:27:38,280 --> 03:27:42,360
EACH OTHER LAST TIME WITHOUT 

5006
03:27:42,360 --> 03:27:50,800
WASTING TIME I INVITE SUSAN 

5007
03:27:50,800 --> 03:28:13,120
RESNICK TO PRESENT.

5008
03:28:13,120 --> 03:28:29,760
>> THE CHALLENGES STILL REMAIN.

5009
03:28:29,760 --> 03:28:32,720
I'VE BEEN ASKED TO PRESENT FOR 

5010
03:28:32,720 --> 03:28:38,120
THE LABORATORY OF BEHAVIORAL 

5011
03:28:38,120 --> 03:28:39,560
NEUROSCIENCE.

5012
03:28:39,560 --> 03:28:41,480
AND THE GOAL OF OUR PROGRAM IS 

5013
03:28:41,480 --> 03:28:44,440
TO UNDERSTAND MECHANISMS OF 

5014
03:28:44,440 --> 03:28:48,120
INDIVIDUAL DIFFERENCES AND AGE 

5015
03:28:48,120 --> 03:28:50,800
ASSOCIATED COGNITIVE VARIATION.

5016
03:28:50,800 --> 03:28:58,160
FROM ANIMAL TO HUMAN MODELS WITH

5017
03:28:58,160 --> 03:29:02,920
THE GOAL TO PROMOTE SUCCESSFUL 

5018
03:29:02,920 --> 03:29:03,200
OUTCOMES.

5019
03:29:03,200 --> 03:29:06,920
THE LABORATORY OF BEHAVIORAL 

5020
03:29:06,920 --> 03:29:08,920
NEUROSCIENCE HAS FIVE PRINCIPLE 

5021
03:29:08,920 --> 03:29:11,480
INVESTIGATORS NOW.

5022
03:29:11,480 --> 03:29:16,920
I LEAD THE LABORATORY AND SERVE 

5023
03:29:16,920 --> 03:29:21,280
AS CHIEF AND WE'RE JOINED BY BY 

5024
03:29:21,280 --> 03:29:24,400
THESE PEOPLE AND LAST MONTH 

5025
03:29:24,400 --> 03:29:27,360
DR. BENJAMINI JOINED AND WILL 

5026
03:29:27,360 --> 03:29:29,200
WORK ON INTEGRATIVE BIOPHYSICS.

5027
03:29:29,200 --> 03:29:32,120
I'D LIKE TO START WITH SOME OF 

5028
03:29:32,120 --> 03:29:36,920
THE PROGRESS THAT WE'VE MADE 

5029
03:29:36,920 --> 03:29:46,400
OVER THE LAST YEAR DESPITE THE 

5030
03:29:46,400 --> 03:29:48,720
PANDEMIC AND THERE'S ONLY ONE 

5031
03:29:48,720 --> 03:29:53,240
GROUP REGULARLY AT THE CENTER 

5032
03:29:53,240 --> 03:29:57,800
OTHER THAN A FEW TEST 

5033
03:29:57,800 --> 03:29:59,360
PARTICIPANTS THE REST OF US HAVE

5034
03:29:59,360 --> 03:30:00,960
WORKED REMOTELY.

5035
03:30:00,960 --> 03:30:05,400
THERE'S A PROGRAM CALL STARRRS, 

5036
03:30:05,400 --> 03:30:09,920
SUCCESSFUL TRAJECTORY OF AGING 

5037
03:30:09,920 --> 03:30:11,000
AND THIS RESERVE AND RESILIENCE 

5038
03:30:11,000 --> 03:30:12,320
IN RATS.

5039
03:30:12,320 --> 03:30:14,520
THE IDEA OF RESERVE AND 

5040
03:30:14,520 --> 03:30:17,040
RESILIENCE IS A THEME THAT CUTS 

5041
03:30:17,040 --> 03:30:18,880
THROUGH THE LABORATORY AS WE TRY

5042
03:30:18,880 --> 03:30:21,560
TO LOOK FOR FACTORS THAT PROMOTE

5043
03:30:21,560 --> 03:30:21,960
SUCCESSFUL AGING.

5044
03:30:21,960 --> 03:30:24,240
THE GOAL OF STARS IS TO 

5045
03:30:24,240 --> 03:30:26,240
ESTABLISH AN OPEN RESOURCE FOR 

5046
03:30:26,240 --> 03:30:29,800
THE LONGITUDINAL STUDY OF 

5047
03:30:29,800 --> 03:30:32,120
COGNITIVE IN MALE AND FEMALE 

5048
03:30:32,120 --> 03:30:34,120
RATS AND RECOGNIZE AGE AND 

5049
03:30:34,120 --> 03:30:35,640
RESILIENCE AGAINST ALZHEIMER'S 

5050
03:30:35,640 --> 03:30:38,160
DISEASE AND RELATED DISORDERS.

5051
03:30:38,160 --> 03:30:42,320
WHAT THIS PROJECT ENTAIL IS FULL

5052
03:30:42,320 --> 03:30:45,920
LONGITUDINAL DATA SETS FROM MORE

5053
03:30:45,920 --> 03:30:48,120
THAN 700 RATS AND THE STUDY WILL

5054
03:30:48,120 --> 03:30:50,520
BE POWERED TO LOOK AT SEX 

5055
03:30:50,520 --> 03:30:54,360
DIFFERENCES IN THE ANIMAL MODEL.

5056
03:30:54,360 --> 03:30:57,080
THEY EXPECT TO COLLECT MORE THAN

5057
03:30:57,080 --> 03:30:59,720
2,000 MRI DATA SETS AND 

5058
03:30:59,720 --> 03:31:00,120
BIOSPECIMENS.

5059
03:31:00,120 --> 03:31:02,720
AGAIN, DUE TO COVID, THERE WERE 

5060
03:31:02,720 --> 03:31:04,280
A NUMBER OF PROGRAM RELATED 

5061
03:31:04,280 --> 03:31:09,640
DELAYS BUT I'M HAPPY TO REPORT 

5062
03:31:09,640 --> 03:31:11,760
THAT THE ANIMAL MAGNET WAS 

5063
03:31:11,760 --> 03:31:14,080
INSTALLED IN THE BRC IN LATE 

5064
03:31:14,080 --> 03:31:16,920
OCTOBER AND THIS IS A PICTURE OF

5065
03:31:16,920 --> 03:31:19,560
THE INSTALLATION.

5066
03:31:19,560 --> 03:31:23,480
AND DR. RAFF HAS USED THE TIME 

5067
03:31:23,480 --> 03:31:24,720
TO LOOK AT THE PHENOTYPING 

5068
03:31:24,720 --> 03:31:26,560
STRUCTURE AND MONITORING AND 

5069
03:31:26,560 --> 03:31:27,560
OPTIMIZATION OF THE OTHER 

5070
03:31:27,560 --> 03:31:33,400
METHODS AND THIS IS ILLUSTRATED 

5071
03:31:33,400 --> 03:31:35,720
IN THIS COLLAGE MUCH PICTURES.

5072
03:31:35,720 --> 03:31:38,920
IN THE NEXT PHASE, HIS PLAN IS 

5073
03:31:38,920 --> 03:31:40,480
TO BEGIN THE LARGE-SCALE DATA 

5074
03:31:40,480 --> 03:31:42,600
COLLECTION AND ESTABLISH A 

5075
03:31:42,600 --> 03:31:45,120
WEB-BASED COORDINATION AND 

5076
03:31:45,120 --> 03:31:48,480
DIGITAL DATA CENTER AS WELL AS A

5077
03:31:48,480 --> 03:31:52,000
BIOSPECIMEN REPOSITORY AND THE 

5078
03:31:52,000 --> 03:31:55,520
SPECIMENS WILL BE DISTRIBUTED 

5079
03:31:55,520 --> 03:31:56,120
THROUGHOUT THE EXTRAMURAL 

5080
03:31:56,120 --> 03:31:57,400
PROGRAM AS WELL AS THE 

5081
03:31:57,400 --> 03:31:57,960
INTRAMURAL PROGRAM.

5082
03:31:57,960 --> 03:32:01,480
IN MY OWN PROGRAM, WE'VE ALSO 

5083
03:32:01,480 --> 03:32:03,520
BEEN CHALLENGED BY COVID.

5084
03:32:03,520 --> 03:32:08,320
OUR PET SCAN STUDIES BASICALLY 

5085
03:32:08,320 --> 03:32:10,920
CAME TO A STOP OVER A YEAR.

5086
03:32:10,920 --> 03:32:19,120
WE HAVE RESTARTED SCANNING BLSA 

5087
03:32:19,120 --> 03:32:20,120
PARTICIPANTS WIH

5088
03:32:20,120 --> 03:32:23,280
PARTICIPANTS BUT AT A MUCH 

5089
03:32:23,280 --> 03:32:24,440
REDUCED RATE.

5090
03:32:24,440 --> 03:32:30,440
SO WE TOOK THE OPPORTUNITY TO 

5091
03:32:30,440 --> 03:32:34,880
COMPLETE PLASMA BIOMARKERS ON 

5092
03:32:34,880 --> 03:32:38,800
ONE HAS BEEN COMPLETED IN 

5093
03:32:38,800 --> 03:32:39,920
COLLABORATION WITH JOHNS HOPKINS

5094
03:32:39,920 --> 03:32:45,480
WHO RUNS THE SAMPLE IN DUPLICATE

5095
03:32:45,480 --> 03:32:53,800
AND OUR TAO SAMPLES ARE PENDING 

5096
03:32:53,800 --> 03:32:56,360
AND HOPE TO GET THEM SOON.

5097
03:32:56,360 --> 03:32:59,920
WE HAD A CROSS-SECTIONAL DATA 

5098
03:32:59,920 --> 03:33:02,160
SET BASED ON THE FIRST THREE 

5099
03:33:02,160 --> 03:33:04,360
TMRI VISITS PARTICIPANTS HAD AND

5100
03:33:04,360 --> 03:33:06,440
THAT WAS ABOUT 700 PARTICIPANTS 

5101
03:33:06,440 --> 03:33:08,280
ACROSS THE FULL AGE RANGE.

5102
03:33:08,280 --> 03:33:10,720
THEN WE TOOK ALL OF THE 

5103
03:33:10,720 --> 03:33:13,880
PARTICIPANT VISITS WHERE WE HAD 

5104
03:33:13,880 --> 03:33:21,480
THE MEASUREMENTS AND THAT 

5105
03:33:21,480 --> 03:33:22,920
CONSTITUTES OUR SPECIMEN AND 

5106
03:33:22,920 --> 03:33:25,880
THAT WAS OVER 600 PEOPLE FOR 200

5107
03:33:25,880 --> 03:33:30,000
VISITS FOR THE INDIVIDUALS.

5108
03:33:30,000 --> 03:33:39,840
I HAVE THE RATIOS AND GFAP AND 

5109
03:33:39,840 --> 03:33:41,720
THE RATIO DECLINES WITH AGE 

5110
03:33:41,720 --> 03:33:46,360
CONSISTENT WITH A DECLINE IN THE

5111
03:33:46,360 --> 03:33:48,920
PRESENCE OF ALZHEIMER'S DISEASE,

5112
03:33:48,920 --> 03:33:50,920
GFAP INCREASES AND YOU CAN SEE 

5113
03:33:50,920 --> 03:33:57,320
THESE ARE PRETTY NOISY.

5114
03:33:57,320 --> 03:34:02,800
DESPITE THAT NOISE WE GET GOOD 

5115
03:34:02,800 --> 03:34:04,800
COEFFICIENTS FOR STABILITY OVER 

5116
03:34:04,800 --> 03:34:09,480
TIME BETWEEN AROUND .7 TO .75 

5117
03:34:09,480 --> 03:34:11,320
THOUGH THE INDIVIDUAL MEASURES 

5118
03:34:11,320 --> 03:34:12,360
ARE QUITE A BIT LOWER.

5119
03:34:12,360 --> 03:34:18,160
SO WHAT DO WE SEE IN THE BLSA 

5120
03:34:18,160 --> 03:34:24,120
WHEN WE LOOK AT PLASMA 

5121
03:34:24,120 --> 03:34:24,880
BIOMARKERS AND PIB AT THE LAST 

5122
03:34:24,880 --> 03:34:26,280
VISIT AND THERE ARE DIFFERENCES 

5123
03:34:26,280 --> 03:34:27,760
BETWEEN PEOPLE WHO ARE POSITIVE 

5124
03:34:27,760 --> 03:34:30,120
OR HAVE AMYLOID IN THEIR BRAIN 

5125
03:34:30,120 --> 03:34:30,920
VERSUS NEGATIVE.

5126
03:34:30,920 --> 03:34:32,840
I WANT TO POINT OUT WE USED A 

5127
03:34:32,840 --> 03:34:37,120
LOW LEVEL OF DETECTABLE PIB TO 

5128
03:34:37,120 --> 03:34:39,640
CALL SOMEBODY POSITIVE IN THE 

5129
03:34:39,640 --> 03:34:39,920
ANALYSES.

5130
03:34:39,920 --> 03:34:43,920
DESPITE THE LOW LEVEL, WE SEE 

5131
03:34:43,920 --> 03:34:49,840
DIFFERENCES IN A BETA RATIO IN 

5132
03:34:49,840 --> 03:34:53,960
GFAP AND NFL.

5133
03:34:53,960 --> 03:34:58,240
AS YOU'D EXPECT, GIVEN PIB SAY 

5134
03:34:58,240 --> 03:34:59,040
MEASURE OF AMYLOID.

5135
03:34:59,040 --> 03:35:03,680
WHEN YOU LOOK AT HOW WELL THE 

5136
03:35:03,680 --> 03:35:05,320
RATIO PREDICTS POSITIVITY, THE 

5137
03:35:05,320 --> 03:35:10,640
AREA UNDER THE CURVE IS ABOUT .7

5138
03:35:10,640 --> 03:35:11,840
AND NOT GREAT BUT PROBABLY THE 

5139
03:35:11,840 --> 03:35:14,120
WAY THEY'LL BE USED AS OTHERS 

5140
03:35:14,120 --> 03:35:16,360
HAVE SUGGESTED IS TO DECREASE 

5141
03:35:16,360 --> 03:35:20,880
THE NUMBER OF PEOPLE THAT GO FOR

5142
03:35:20,880 --> 03:35:24,400
PIB SCANS OR FOR AMYLOID SCANS 

5143
03:35:24,400 --> 03:35:26,080
IN GENERAL FOR SELECTION INTO 

5144
03:35:26,080 --> 03:35:27,120
CLINICAL TRIALS RATHER THAN AS A

5145
03:35:27,120 --> 03:35:36,520
STAND ALONE MEASURE RIGHT NOW.

5146
03:35:36,520 --> 03:35:42,800
DR. WALKER JOINED IN 2020 AND 

5147
03:35:42,800 --> 03:35:44,640
HAS BEEN ENTIRELY REMOTE SINCE 

5148
03:35:44,640 --> 03:35:48,360
JOINING AND DESPITE THAT HE'S 

5149
03:35:48,360 --> 03:35:55,440
BEEN REMARKABLY PRODUCTIVE AND 

5150
03:35:55,440 --> 03:35:56,160
DEVELOPED A SUCCESSFUL 

5151
03:35:56,160 --> 03:35:59,280
INTRAMURAL LAB PROPOSAL WHICH 

5152
03:35:59,280 --> 03:36:02,880
WAS SUPPLEMENTED BY THE 

5153
03:36:02,880 --> 03:36:03,480
DISTINGUISHED SCHOLARS FUNDING 

5154
03:36:03,480 --> 03:36:07,720
TO PERFORM PROTEOMICS AND 

5155
03:36:07,720 --> 03:36:10,240
ADDITIONAL PLASMA P TAO AND 

5156
03:36:10,240 --> 03:36:15,200
OTHER MEASURES USING THE 

5157
03:36:15,200 --> 03:36:16,800
LONGITUDINAL MRI EXAMPLE.

5158
03:36:16,800 --> 03:36:19,280
AND HE ALSO WITH HIS GROUP 

5159
03:36:19,280 --> 03:36:23,480
QUICKLY JUMPED INTO THE EXISTING

5160
03:36:23,480 --> 03:36:24,880
BLSA DATA AND DR. WALKER IS 

5161
03:36:24,880 --> 03:36:25,840
INTERESTED IN INFLAMMATION.

5162
03:36:25,840 --> 03:36:30,120
THEY WERE ABLE TO IDENTIFY A 

5163
03:36:30,120 --> 03:36:32,880
SAMPLE THAT REPORTED IN THE BLSA

5164
03:36:32,880 --> 03:36:34,560
HERPES VIRUS AND COMPARED THOSE 

5165
03:36:34,560 --> 03:36:39,400
INDIVIDUALS WHO DID NOT REPORT 

5166
03:36:39,400 --> 03:36:41,360
PRIOR HERPES VIRUS INFECTION AND

5167
03:36:41,360 --> 03:36:44,280
FOUND THERE WAS GREATER 

5168
03:36:44,280 --> 03:36:46,640
LONGITUDINAL WHITE MATTER VOLUME

5169
03:36:46,640 --> 03:36:49,920
LOSS AS ILLUSTRATED IN THE 

5170
03:36:49,920 --> 03:36:52,720
BOTTOM HERE THAN THOSE WHO HAD 

5171
03:36:52,720 --> 03:36:55,440
PREVIOUSLY REPORTED A HERPES 

5172
03:36:55,440 --> 03:36:59,760
INFECTION AND IT WAS MOST 

5173
03:36:59,760 --> 03:37:01,320
PRONOUNCED IN THE TEMPORAL WHITE

5174
03:37:01,320 --> 03:37:08,000
MATTER LOSS.

5175
03:37:08,000 --> 03:37:12,880
AND THERE'S BEEN A STUDY DREAM, 

5176
03:37:12,880 --> 03:37:15,400
DRUG REPURPOSING FOR EFFECTIVE 

5177
03:37:15,400 --> 03:37:16,360
ALZHEIMER'S MEDICINE.

5178
03:37:16,360 --> 03:37:20,200
THIS IS A TWO-YEAR MULTI-CENTER 

5179
03:37:20,200 --> 03:37:22,240
STUDY IDENTIFY NOVEL REPURPOSING

5180
03:37:22,240 --> 03:37:23,160
CANDIDATES FOR ALZHEIMER'S 

5181
03:37:23,160 --> 03:37:26,360
DISEASE WHERE HE LEVERAGES BOTH 

5182
03:37:26,360 --> 03:37:29,040
DEEP MOLECULAR PHENOTYPING OF 

5183
03:37:29,040 --> 03:37:31,920
HUMAN BRAIN AND BLOOD AND BIG 

5184
03:37:31,920 --> 03:37:34,000
DATA ANALYSIS OF REAL WORLD 

5185
03:37:34,000 --> 03:37:36,400
OUTCOMES IN COLLABORATION WITH 

5186
03:37:36,400 --> 03:37:38,960
EXTRAMURAL INVESTIGATORS, 

5187
03:37:38,960 --> 03:37:40,320
THEY'VE IDENTIFIED TWO CLINICAL 

5188
03:37:40,320 --> 03:37:43,280
DATA SETS WITH OVER 20 MILLION 

5189
03:37:43,280 --> 03:37:48,120
OLDER INDIVIDUALS WITH CLINICAL 

5190
03:37:48,120 --> 03:37:52,320
DIAGNOSES DATA AND USE THE DATA 

5191
03:37:52,320 --> 03:37:56,800
SETS TO IDENTIFY TARGETS THAT 

5192
03:37:56,800 --> 03:37:59,320
BEAR FURTHER INVESTIGATION 

5193
03:37:59,320 --> 03:38:01,520
POSSIBLY IN RANDOMIZED CLINICAL 

5194
03:38:01,520 --> 03:38:06,160
TRIALS AS CANDIDATE AB TREATMENT

5195
03:38:06,160 --> 03:38:06,480
FUTURE.

5196
03:38:06,480 --> 03:38:08,640
WITH HIS PROGRAM AND THE DREAM 

5197
03:38:08,640 --> 03:38:12,480
STUDY BUT THEY'VE BEEN 

5198
03:38:12,480 --> 03:38:15,560
SUCCESSFUL AT USING DRUG 

5199
03:38:15,560 --> 03:38:16,920
DISCOVERY IN ALZHEIMER'S DISEASE

5200
03:38:16,920 --> 03:38:18,720
USING OMICS TO IDENTIFY 

5201
03:38:18,720 --> 03:38:23,800
PLAUSIBLE TARGETS IN A RECENT 

5202
03:38:23,800 --> 03:38:27,720
PAPER THEY IDENTIFIED THE 

5203
03:38:27,720 --> 03:38:29,200
JAK-STAT MODULATION AS IMPORTANT

5204
03:38:29,200 --> 03:38:31,200
IN ALZHEIMER'S DISEASE AND NOW 

5205
03:38:31,200 --> 03:38:35,320
TAKEN THAT WHERE THEY'RE 

5206
03:38:35,320 --> 03:38:38,040
PROPOSING THREE DIFFERENT 

5207
03:38:38,040 --> 03:38:39,720
COMPARISONS IN THE REAL WORLD 

5208
03:38:39,720 --> 03:38:41,840
CLINICAL DATA SETS TO TEST 

5209
03:38:41,840 --> 03:38:46,400
WHETHER OR NOT DRUGS THAT 

5210
03:38:46,400 --> 03:38:48,400
MODULATE THAT PATHWAY HAVE 

5211
03:38:48,400 --> 03:38:51,640
EFFECTS ON ALZHEIMER'S DISEASE 

5212
03:38:51,640 --> 03:38:52,800
RISK IN THE REAL WORLD CLINICAL 

5213
03:38:52,800 --> 03:38:53,720
DATA SETS.

5214
03:38:53,720 --> 03:38:58,120
IN THE LAST EXAMPLE, I'D LIKE TO

5215
03:38:58,120 --> 03:39:00,720
SHOW YOU PROGRESS MADE IN THE 

5216
03:39:00,720 --> 03:39:03,800
WOMEN'S HEALTH INITIATIVE MEMORY

5217
03:39:03,800 --> 03:39:05,280
STUDY WE'RE ALL WORKING ON 

5218
03:39:05,280 --> 03:39:08,720
TOGETHER WITH OTHER INDIVIDUALS 

5219
03:39:08,720 --> 03:39:09,480
IN THE INTRAMURAL RESEARCH 

5220
03:39:09,480 --> 03:39:14,120
PROGRAM AND AT WAKE FOREST TO 

5221
03:39:14,120 --> 03:39:15,600
UNDERSTAND THE COGNITIVE 

5222
03:39:15,600 --> 03:39:23,120
RESILIENCE IN APOE4 ESCAPEES AND

5223
03:39:23,120 --> 03:39:26,120
MAKE IT TO AGE 80 AND OLDER 

5224
03:39:26,120 --> 03:39:27,600
WITHOUT COGNITIVE IMPAIRMENT.

5225
03:39:27,600 --> 03:39:30,920
SO WE WENT BACK TO THE BAG AND 

5226
03:39:30,920 --> 03:39:32,920
PULLED SAMPLES FROM THE WOMEN'S 

5227
03:39:32,920 --> 03:39:34,120
HEALTH INITIATIVE BASELINE FROM 

5228
03:39:34,120 --> 03:39:38,320
THE MID 1990s AND THEN LOOKED AT

5229
03:39:38,320 --> 03:39:43,160
SELECTED PLASMID BIOMARKERS AND 

5230
03:39:43,160 --> 03:39:46,160
METABOLOMICS AND WITH THE LIMIT 

5231
03:39:46,160 --> 03:39:48,800
THE TIME I WANTED TO SHARE THE 

5232
03:39:48,800 --> 03:39:50,240
PLASMA BIOMARKER THE REST OF 

5233
03:39:50,240 --> 03:39:54,480
THIS IS IN PROGRESS IN TERMS OF 

5234
03:39:54,480 --> 03:39:54,760
ANALYSIS.

5235
03:39:54,760 --> 03:39:57,680
WHAT WE HAVE ARE PEOPLE WHO ARE 

5236
03:39:57,680 --> 03:40:03,120
LESS THAN AGE 80 AND IMPAIRED IN

5237
03:40:03,120 --> 03:40:04,800
THE RED DOTS.

5238
03:40:04,800 --> 03:40:06,480
PEOPLE WHO BECAME IMPAIRED AFTER

5239
03:40:06,480 --> 03:40:09,760
AGE 80 AND THEN RESILIENT 

5240
03:40:09,760 --> 03:40:10,080
INDIVIDUALS.

5241
03:40:10,080 --> 03:40:11,120
AND THOSE ARE THE PEOPLE WHO 

5242
03:40:11,120 --> 03:40:13,240
MAKE IT TO AGE 80 WITHOUT 

5243
03:40:13,240 --> 03:40:17,320
COGNITIVE IMPAIRMENT.

5244
03:40:17,320 --> 03:40:19,000
YOU CAN START WITH THE RATIO ON 

5245
03:40:19,000 --> 03:40:19,560
THE LEFT.

5246
03:40:19,560 --> 03:40:20,880
THERE'S A COUPLE THINGS THAT ARE

5247
03:40:20,880 --> 03:40:21,120
OBVIOUS.

5248
03:40:21,120 --> 03:40:24,160
ONE IS WHEN WE STRATIFY BY E4 

5249
03:40:24,160 --> 03:40:27,240
GENOTYPE FOR ALL OF THE GROUPS, 

5250
03:40:27,240 --> 03:40:33,040
THE E4 GENOTYPE GROUPS HAVE 

5251
03:40:33,040 --> 03:40:41,600
LOWER ABETA RATIO AND IT'S 

5252
03:40:41,600 --> 03:40:43,240
HIGHER IN A4 POSITIVE 

5253
03:40:43,240 --> 03:40:43,520
INDIVIDUALS.

5254
03:40:43,520 --> 03:40:44,720
THAT'S ONE ASPECT.

5255
03:40:44,720 --> 03:40:49,320
THE SECOND IS THAT IF YOU LOOK 

5256
03:40:49,320 --> 03:40:52,120
AT THE E4 INDIVIDUALS, YOU CAN 

5257
03:40:52,120 --> 03:40:58,320
SEE THERE IS NOT MUCH OF A 

5258
03:40:58,320 --> 03:41:03,720
DIFFERENCE BETWEEN THE TWO 

5259
03:41:03,720 --> 03:41:06,480
GROUPS IMPAIRED AND BY CONTRAST 

5260
03:41:06,480 --> 03:41:08,800
IN THE E3 INDIVIDUALS THEY'RE 

5261
03:41:08,800 --> 03:41:11,480
IMPAIRED AFTER AGE 80, ARE 

5262
03:41:11,480 --> 03:41:13,840
SOMEWHAT ELEVATED RELATIVE TO 

5263
03:41:13,840 --> 03:41:15,760
THE PEOPLE WHO DEVELOPED 

5264
03:41:15,760 --> 03:41:16,640
IMPAIRMENT BEFORE AGE 80.

5265
03:41:16,640 --> 03:41:18,360
AND I THINK WHAT THAT SUGGESTS 

5266
03:41:18,360 --> 03:41:21,760
IS THAT THE E4 GROUP IS MORE 

5267
03:41:21,760 --> 03:41:24,920
HETEROGENEOUS AND THERE'S MANY 

5268
03:41:24,920 --> 03:41:30,440
FACTORS THAT MAY BE RELATED.

5269
03:41:30,440 --> 03:41:32,920
THEY MAY NOT BE AS DRIVEN BY THE

5270
03:41:32,920 --> 03:41:35,240
A BETA PATHWAY.

5271
03:41:35,240 --> 03:41:40,480
IF WE LOOK AT NFL WE CAN SEE IN 

5272
03:41:40,480 --> 03:41:42,800
THE IMPAIRED AND RESILIENT 

5273
03:41:42,800 --> 03:41:44,200
GROUPS AFTER 80 THEY'RE SIMILAR 

5274
03:41:44,200 --> 03:41:47,440
FOR THE E3 AND E4 BUT THE PEOPLE

5275
03:41:47,440 --> 03:41:52,880
YOUNGER DEVELOPED IMPAIRMENT AT 

5276
03:41:52,880 --> 03:41:56,520
YOUNGER AGES, THEY SHOW THE 

5277
03:41:56,520 --> 03:41:59,240
ELEVATION IN THE NFL AND THEY'RE

5278
03:41:59,240 --> 03:42:01,960
CLOSER TO THE WHI BASELINE AND 

5279
03:42:01,960 --> 03:42:03,440
FIVE YEARS ON AVERAGE FROM THE 

5280
03:42:03,440 --> 03:42:05,040
BASELINE AND 80 PLUS IMPAIRED 

5281
03:42:05,040 --> 03:42:07,880
ARE CLOSER TO 12 TO 14 YEARS 

5282
03:42:07,880 --> 03:42:09,120
FROM THE WHI BASELINE.

5283
03:42:09,120 --> 03:42:15,120
SO THESE ARE JUST A FEW SNIPPETS

5284
03:42:15,120 --> 03:42:17,800
OF THE PROGRESS SINCE THE LAST 

5285
03:42:17,800 --> 03:42:19,120
REVIEW AND HAPPY TO TAKE 

5286
03:42:19,120 --> 03:42:20,920
QUESTIONS AND THANK YOU FOR 

5287
03:42:20,920 --> 03:42:37,960
LISTENING.

5288
03:42:37,960 --> 03:42:40,040
>> THANK YOU, SUSAN.

5289
03:42:40,040 --> 03:42:43,360
WE HAVE TIME FOR A QUESTION.

5290
03:42:43,360 --> 03:42:44,960
IF THERE ARE NOT ANY, WE CAN 

5291
03:42:44,960 --> 03:42:45,320
MOVE ON.

5292
03:42:45,320 --> 03:42:46,720
>> I HAVE A QUESTION.

5293
03:42:46,720 --> 03:42:47,920
THANK YOU FOR YOUR PRESENTATION,

5294
03:42:47,920 --> 03:42:48,160
SUSAN.

5295
03:42:48,160 --> 03:42:54,400
NICE TO SEE THAT WORK, AS 

5296
03:42:54,400 --> 03:42:54,640
ALWAYS.

5297
03:42:54,640 --> 03:42:57,000
ARE YOU GOING TO BE USING PLASMA

5298
03:42:57,000 --> 03:42:59,120
BIOMARKERS TO FURTHER INFORM THE

5299
03:42:59,120 --> 03:43:01,000
EFFECTS OF ESTROGEN REPLACEMENT 

5300
03:43:01,000 --> 03:43:23,480
THERAPY?

5301
03:43:23,480 --> 03:43:28,760
>> THERE'S A MORE SAMPLE WE'RE 

5302
03:43:28,760 --> 03:43:29,080
LOOKING TO.

5303
03:43:29,080 --> 03:43:40,120
>> THANK YOU.

5304
03:43:40,120 --> 03:43:44,240
>> GOOD AFTERNOON, EVERYONE.

5305
03:43:44,240 --> 03:43:48,080
I'M LENORE LAUNER THE CHIEF OF 

5306
03:43:48,080 --> 03:43:48,680
EPIDEMIOLOGY AND POPULATION 

5307
03:43:48,680 --> 03:43:50,360
SCIENCES AND PLEASED TO PRESENT 

5308
03:43:50,360 --> 03:43:55,280
A BRIEF OVERVIEW OF LEPS HISTORY

5309
03:43:55,280 --> 03:44:02,480
AS WELL AS FUTURE PLANS.

5310
03:44:02,480 --> 03:44:04,720
THE LABORATORY AIMS FOCUSES ON 

5311
03:44:04,720 --> 03:44:09,000
RESEARCH TO FULFILL THE NIH/IRP 

5312
03:44:09,000 --> 03:44:11,800
MISSION OF CONDUCTING HIGH 

5313
03:44:11,800 --> 03:44:15,240
QUALITY GROUNDBREAKING RESEARCH 

5314
03:44:15,240 --> 03:44:17,120
ADVANCING HUMAN HEALTH THROUGH 

5315
03:44:17,120 --> 03:44:23,320
EARLY DETECTION, DIAGNOSIS AND 

5316
03:44:23,320 --> 03:44:27,960
TREATMENT AND USING INTEGRATIVE 

5317
03:44:27,960 --> 03:44:28,720
AND TRANSLATIONAL MODEL.

5318
03:44:28,720 --> 03:44:31,040
WE TAKE A WHOLE PERSON APPROACH 

5319
03:44:31,040 --> 03:44:32,920
TO STUDY THE SYSTEMS RELATED TO 

5320
03:44:32,920 --> 03:44:34,320
HEALTH DISPARITIES, CHRONIC 

5321
03:44:34,320 --> 03:44:37,920
DISEASE AND BRAIN AGING AND 

5322
03:44:37,920 --> 03:44:39,080
IDENTIFY INTERACTIONS AMONG 

5323
03:44:39,080 --> 03:44:41,200
SOCIO ECONOMIC AND ENVIRONMENTAL

5324
03:44:41,200 --> 03:44:44,840
FACTORS IN RELATION TO HEALTH 

5325
03:44:44,840 --> 03:44:47,080
OUTCOMES AND MAP OUT 

5326
03:44:47,080 --> 03:44:50,720
TRAJECTORIES OF RISK AND DISEASE

5327
03:44:50,720 --> 03:44:51,720
AND INVESTIGATE SIGNATURES OF 

5328
03:44:51,720 --> 03:44:53,160
RISK AND PROGNOSIS.

5329
03:44:53,160 --> 03:44:58,160
I'LL GIVE YOU A BRIEF OVERVIEW 

5330
03:44:58,160 --> 03:44:59,480
OF WHAT OUR MOST CURRENT 

5331
03:44:59,480 --> 03:45:04,360
RESEARCH FINDINGS ARE.

5332
03:45:04,360 --> 03:45:05,960
IN THE LAST DECADE THERE'S BEEN 

5333
03:45:05,960 --> 03:45:07,440
A LOT OF CHANGES IN OUR 

5334
03:45:07,440 --> 03:45:10,800
INFORMATION OF AGING AND 

5335
03:45:10,800 --> 03:45:12,160
POPULATION LEVEL IN PARTICULAR.

5336
03:45:12,160 --> 03:45:13,440
THERE'S SOME WORKING PREMISES 

5337
03:45:13,440 --> 03:45:17,080
THAT LEPS HAS CONTRIBUTED TO 

5338
03:45:17,080 --> 03:45:17,480
CHANGING.

5339
03:45:17,480 --> 03:45:18,480
THE MOST OBVIOUS BEING BETWEEN 

5340
03:45:18,480 --> 03:45:21,480
GENES AND AGE, THERE WAS AN 

5341
03:45:21,480 --> 03:45:22,720
INEVITABLE DECLINE IN HEALTH 

5342
03:45:22,720 --> 03:45:25,360
WITH FEW MEANS TO PREVENT THE 

5343
03:45:25,360 --> 03:45:29,320
DECLINE AND AGE HAD A 

5344
03:45:29,320 --> 03:45:31,280
CHRONOLOGIC TRAJECTORY STARTING 

5345
03:45:31,280 --> 03:45:31,840
AT AGE 65.

5346
03:45:31,840 --> 03:45:34,800
SO BRIEFLY I'LL SHOW YOU SOME OF

5347
03:45:34,800 --> 03:45:36,280
THE CURRENT RESEARCH THAT HAS 

5348
03:45:36,280 --> 03:45:36,880
HELPED CHALLENGE THE OLDER 

5349
03:45:36,880 --> 03:45:44,480
PREMISES.

5350
03:45:44,480 --> 03:45:47,080
THEY'VE LOOKED AT THE 

5351
03:45:47,080 --> 03:45:52,200
RELATIONSHIP BETWEEN EPIGENETIC 

5352
03:45:52,200 --> 03:45:54,320
CHANGES ON AGE ACCELERATION AND 

5353
03:45:54,320 --> 03:45:57,400
THE AFFECT OF AGE ON COGNITIVE 

5354
03:45:57,400 --> 03:45:58,280
DECLINE.

5355
03:45:58,280 --> 03:45:59,680
WE HAVE ALSO EXAMINED BIOMARKERS

5356
03:45:59,680 --> 03:46:03,920
OF AGING IN THE POPULATION AND 

5357
03:46:03,920 --> 03:46:05,160
THERE WAS AN ASSOCIATION BETWEEN

5358
03:46:05,160 --> 03:46:07,440
GENES AND PROTEIN NETWORKS AND 

5359
03:46:07,440 --> 03:46:08,920
THEY PREDICT DISEASE SUGGESTING 

5360
03:46:08,920 --> 03:46:11,680
THE USE OF SUCH NETWORKS IN 

5361
03:46:11,680 --> 03:46:14,840
DEFINING DISEASE RISK MAY BE 

5362
03:46:14,840 --> 03:46:15,920
USEFUL.

5363
03:46:15,920 --> 03:46:20,120
AND TESTS LOOKING AT TELOMERE 

5364
03:46:20,120 --> 03:46:21,720
LENGTH AND PROTEINS HAVE SHOWN 

5365
03:46:21,720 --> 03:46:24,920
THE MARKERS CAN VARY IN 

5366
03:46:24,920 --> 03:46:26,840
COMPOSITION AND DEGREE OF 

5367
03:46:26,840 --> 03:46:28,480
ASSOCIATION BY THE DIVERSITY OF 

5368
03:46:28,480 --> 03:46:34,880
THE SAMPLE THAT IS BEING 

5369
03:46:34,880 --> 03:46:35,720
EXAMINED.

5370
03:46:35,720 --> 03:46:39,520
AND SOCIAL FACTORS SUCH AS 

5371
03:46:39,520 --> 03:46:41,360
DISCRIMINATION AND LOWER SOCIO 

5372
03:46:41,360 --> 03:46:42,400
ECONOMIC STATUS CAN AFFECT BRAIN

5373
03:46:42,400 --> 03:46:42,920
DISEASE.

5374
03:46:42,920 --> 03:46:46,200
WE ALSO PARTICIPATED IN THE 

5375
03:46:46,200 --> 03:46:56,080
PROJECT OF DR. DE CABOS TO 

5376
03:46:56,080 --> 03:46:57,600
INVESTIGATE INTERSPECIES 

5377
03:46:57,600 --> 03:47:00,920
DIFFERENCES IN METABOLISM AND 

5378
03:47:00,920 --> 03:47:03,520
DIFFERENCES IN LIFE COURSE TRA

5379
03:47:03,520 --> 03:47:06,920
TRAJECTORIES IN GLUCOSE IN MEN, 

5380
03:47:06,920 --> 03:47:08,160
MONKEYS AND MAN.

5381
03:47:08,160 --> 03:47:12,000
WE HAVE BEEN TAKE LIFE COURSE 

5382
03:47:12,000 --> 03:47:17,440
APPROACH AS WE DO OUR SCIENCE.

5383
03:47:17,440 --> 03:47:23,400
WE WORK TO MEET THE AIMS OF OUR 

5384
03:47:23,400 --> 03:47:30,480
STUDY.

5385
03:47:30,480 --> 03:47:32,880
WE DEVELOPED COHORTS AND THEY'VE

5386
03:47:32,880 --> 03:47:34,560
BEEN DESIGNED WITH SPECIFIC 

5387
03:47:34,560 --> 03:47:35,600
SOURCE POPULATIONS IN MIND THAT 

5388
03:47:35,600 --> 03:47:36,880
COULD PROVIDE INSIGHT INTO 

5389
03:47:36,880 --> 03:47:40,880
ASPECTS OF AGING ON A POPULATION

5390
03:47:40,880 --> 03:47:43,680
LEVEL.

5391
03:47:43,680 --> 03:47:45,400
THE COHORTS ARE LARGE, DIVERSE 

5392
03:47:45,400 --> 03:47:46,800
AND COMMUNITY BASED AND FOLLOWED

5393
03:47:46,800 --> 03:47:48,840
OVER TIME AND DEEPLY PHENOTYPED 

5394
03:47:48,840 --> 03:47:54,560
WITH A WIDE RANGE OF SOCIO 

5395
03:47:54,560 --> 03:47:58,760
ECONOMIC STATUS AND 

5396
03:47:58,760 --> 03:48:00,440
COMORBIDITIES AND FUNCTIONAL 

5397
03:48:00,440 --> 03:48:02,840
IMPAIRMENT AND REPRESENT OVER 

5398
03:48:02,840 --> 03:48:05,760
THE YEARS INDIVIDUALS BORN IN 

5399
03:48:05,760 --> 03:48:07,360
DIFFERENT BIRTH COHORTS AND 

5400
03:48:07,360 --> 03:48:12,440
INDIVIDUALS THAT HAVE BEEN 

5401
03:48:12,440 --> 03:48:17,400
FOLLOWED FOR MANY MANY YEARS.

5402
03:48:17,400 --> 03:48:19,680
THESE RESOURCES ARE ALLOWING A 

5403
03:48:19,680 --> 03:48:22,120
WIDE RANGE OF QUESTIONS RELATED 

5404
03:48:22,120 --> 03:48:23,560
TO MULTIPLE PHYSIOLOGIC AND 

5405
03:48:23,560 --> 03:48:28,560
DISEASE PROCESSES AND AGING TO 

5406
03:48:28,560 --> 03:48:30,800
BE ADDRESSED AND DISENTANGLE 

5407
03:48:30,800 --> 03:48:38,120
TRENDS AND INTERACTIONS AMONG 

5408
03:48:38,120 --> 03:48:41,440
DIFFERENT BODY SYSTEMS AT THE 

5409
03:48:41,440 --> 03:48:43,000
SAME TIME.

5410
03:48:43,000 --> 03:48:46,440
OBVIOUSLY, THE RESOURCES AND AS 

5411
03:48:46,440 --> 03:48:48,880
A FEDERAL INSTITUTION WE ALWAYS 

5412
03:48:48,880 --> 03:48:49,840
WORKED COLLABORATIVELY IN THE 

5413
03:48:49,840 --> 03:48:51,240
DESIGN AND EXECUTION OF 

5414
03:48:51,240 --> 03:48:52,400
INTERPRETATION OF FINDINGS.

5415
03:48:52,400 --> 03:48:57,320
IN ADDITION AND IMPORTANTLY, THE

5416
03:48:57,320 --> 03:48:59,160
COHORT SCIENTISTS AND CLINICIANS

5417
03:48:59,160 --> 03:49:02,720
WITH A WIDE RANGE OF SKILLS HAVE

5418
03:49:02,720 --> 03:49:04,800
TAPPED INTO THE RESOURCES AND 

5419
03:49:04,800 --> 03:49:07,320
HAVE ALSO CONTRIBUTED THROUGH 

5420
03:49:07,320 --> 03:49:09,880
GRANTS AND CONTRACTS TO ENRICH 

5421
03:49:09,880 --> 03:49:13,600
THE COHORTS THAT WE HAVE 

5422
03:49:13,600 --> 03:49:14,560
DEVELOPED.

5423
03:49:14,560 --> 03:49:16,920
THERE'S OBVIOUSLY WE HAVE AN 

5424
03:49:16,920 --> 03:49:19,760
AMAZING NETWORK OF COLLABORATION

5425
03:49:19,760 --> 03:49:23,120
NOT ONLY ACROSS NIH BUT 

5426
03:49:23,120 --> 03:49:24,920
NATIONALLY AND INTERNATIONALLY 

5427
03:49:24,920 --> 03:49:28,120
AND MADE MAJOR CONTRIBUTIONS TO 

5428
03:49:28,120 --> 03:49:28,920
MULTIPLE CONSORTIA WHICH 

5429
03:49:28,920 --> 03:49:29,480
EFFECTIVELY INCREASES OUR 

5430
03:49:29,480 --> 03:49:33,200
COLLABORATION WORLDWIDE.

5431
03:49:33,200 --> 03:49:39,320
SO I WOULD LIKE NOW TO GIVE YOU 

5432
03:49:39,320 --> 03:49:41,720
A BIT HISTORY OF LEPS.

5433
03:49:41,720 --> 03:49:44,120
WE STARTED ABOUT 15 YEARS AGO, 

5434
03:49:44,120 --> 03:49:48,040
THERE WAS ATTRITION IN THE LAB 

5435
03:49:48,040 --> 03:49:49,840
DUE TO RETIREMENT.

5436
03:49:49,840 --> 03:49:52,840
SO BY THE 2020 

5437
03:49:54,480 --> 03:50:00,480
 BSC ONLY DR. EVANS RUNNING THE 

5438
03:50:00,480 --> 03:50:08,920
HEATH DISPARITIES SECTION AND ME

5439
03:50:08,920 --> 03:50:11,480
RUNNING DIVISIONS HAVE HELPED 

5440
03:50:11,480 --> 03:50:12,120
AND WE MADE SEVERAL 

5441
03:50:12,120 --> 03:50:13,240
RECOMMENDATIONS HOW TO MOVE 

5442
03:50:13,240 --> 03:50:13,480
FORWARD.

5443
03:50:13,480 --> 03:50:15,800
THEY ADVISED THE INSTITUTE TO 

5444
03:50:15,800 --> 03:50:17,880
EXPAND AND STRENGTHEN LEPS WITH 

5445
03:50:17,880 --> 03:50:21,040
A NEW LAB CHIEF WE HAVE BEEN 

5446
03:50:21,040 --> 03:50:22,920
WORKING UNDER AN ACTING LAB 

5447
03:50:22,920 --> 03:50:25,320
CHIEF MANY YEARS AND DEVELOP A 

5448
03:50:25,320 --> 03:50:27,720
STRATEGIC PLAN AND ASSEMBLE THE 

5449
03:50:27,720 --> 03:50:32,240
FULL TEAM OF NEW TENURE TRACK 

5450
03:50:32,240 --> 03:50:32,560
INVESTIGATORS.

5451
03:50:32,560 --> 03:50:36,440
SPECIFIC AREAS THAT THEY 

5452
03:50:36,440 --> 03:50:38,760
RECOMMENDED TO FOCUS ON CONTINUE

5453
03:50:38,760 --> 03:50:40,480
TO DO RESEARCH ON HEALTH 

5454
03:50:40,480 --> 03:50:44,880
DISPARITIES RESEARCH, DEVELOP OR

5455
03:50:44,880 --> 03:50:45,960
FORMALIZE NEW RESEARCH AREAS 

5456
03:50:45,960 --> 03:50:47,880
RELATING TO NEW CHALLENGES TO 

5457
03:50:47,880 --> 03:50:49,560
HEALTH, TO DEVELOP NEW RESEARCH 

5458
03:50:49,560 --> 03:50:52,120
RESOURCES SUCH AS COHORTS, 

5459
03:50:52,120 --> 03:50:55,520
TRAINING OPPORTUNITIES AND AN 

5460
03:50:55,520 --> 03:50:56,960
EPIDEMIOLOGIC CORPS AND CONTINUE

5461
03:50:56,960 --> 03:50:57,840
BRIDGING THE GAP BETWEEN THE 

5462
03:50:57,840 --> 03:51:02,400
BASIC AND POPULATION SCIENCES.

5463
03:51:02,400 --> 03:51:05,320
SO NOW THESE DAYS CURRENTLY 

5464
03:51:05,320 --> 03:51:07,720
OBVIOUSLY THERE ARE MANY 

5465
03:51:07,720 --> 03:51:11,960
CHALLENGES TO REBUILDING AN 

5466
03:51:11,960 --> 03:51:12,640
EPIDEMIOLOGIC PROGRAM.

5467
03:51:12,640 --> 03:51:15,200
THE CURRENT LANDSCAPE IN 

5468
03:51:15,200 --> 03:51:15,840
UNDERSTANDING WHEN DISEASE HAS 

5469
03:51:15,840 --> 03:51:21,880
BECOME MORE COMPLICATED.

5470
03:51:21,880 --> 03:51:23,760
THERE'S THE AVAILABILITY OF 

5471
03:51:23,760 --> 03:51:25,040
DIGITAL TECHNOLOGY HAS CREATED A

5472
03:51:25,040 --> 03:51:28,160
HUGE AMOUNT OF DATA AVAILABLE 

5473
03:51:28,160 --> 03:51:30,840
FOR US TO GAIN INSIGHT INTO 

5474
03:51:30,840 --> 03:51:32,920
HEALTH AND ALSO LEARNING THERE 

5475
03:51:32,920 --> 03:51:35,840
ARE MANY FACTORS BEYOND 

5476
03:51:35,840 --> 03:51:36,920
PHYSIOLOGIC INFLUENCES THAT 

5477
03:51:36,920 --> 03:51:42,200
INFLUENCE AN INDIVIDUAL'S 

5478
03:51:42,200 --> 03:51:43,480
OUTCOMES AND THEY NECESSITATE 

5479
03:51:43,480 --> 03:51:46,480
TAKING A WHOLE PERSON'S APPROACH

5480
03:51:46,480 --> 03:51:50,240
TO RESEARCH AS WELL AS SYSTEMS 

5481
03:51:50,240 --> 03:51:51,120
BIOLOGY RESEARCH.

5482
03:51:51,120 --> 03:51:54,120
AND INCLUDE NOW IN OUR RESEARCH 

5483
03:51:54,120 --> 03:51:55,960
LOCAL ENVIRONMENT BEHAVIOR, 

5484
03:51:55,960 --> 03:52:00,480
SOCIO CULTURAL CONTEXT AND 

5485
03:52:00,480 --> 03:52:00,960
BASICALLY THE OUTDOORS 

5486
03:52:00,960 --> 03:52:07,440
ENVIRONMENT.

5487
03:52:07,440 --> 03:52:09,120
BASED ON THE BSC 

5488
03:52:09,120 --> 03:52:11,520
RECOMMENDATIONS, I APPLIED FOR 

5489
03:52:11,520 --> 03:52:16,720
THE CHIEF'S POSITION AND WAS 

5490
03:52:16,720 --> 03:52:18,480
APPOINTED LAST YEAR.

5491
03:52:18,480 --> 03:52:20,400
THERE WILL BE AN INVESTMENT IN 

5492
03:52:20,400 --> 03:52:22,240
TENURE TRACK POSITIONS WHICH WE 

5493
03:52:22,240 --> 03:52:26,160
ARE CURRENTLY RECRUITING FOR NOW

5494
03:52:26,160 --> 03:52:32,320
AND I ENVISION THE LAB TO 

5495
03:52:32,320 --> 03:52:36,720
CONCLUDE AT LEAST FOUR SECTIONS 

5496
03:52:36,720 --> 03:52:38,920
A LITTLE BIT PROBABLY NOT 

5497
03:52:38,920 --> 03:52:41,800
PRECISELY LABELLED BUT I 

5498
03:52:41,800 --> 03:52:45,760
ENVISION A DATA SCIENCE SECTION 

5499
03:52:45,760 --> 03:52:47,400
WHERE THE INVESTIGATORS WOULD 

5500
03:52:47,400 --> 03:52:50,600
USE A WIDE RANGE OF LARGE 

5501
03:52:50,600 --> 03:52:52,600
DATABASES TO ADDRESS 

5502
03:52:52,600 --> 03:52:54,400
INTERSECTIONS AMONG SOCIAL, 

5503
03:52:54,400 --> 03:52:56,880
BIOLOGIC AND CLIMATE AND 

5504
03:52:56,880 --> 03:52:58,280
ENVIRONMENTAL FACTORS.

5505
03:52:58,280 --> 03:53:01,320
THERE WOULD BE BIOMARKER SECTION

5506
03:53:01,320 --> 03:53:03,640
FOCUSSED ON DEVELOPING 

5507
03:53:03,640 --> 03:53:06,480
BIOMARKERS BASED ON OMICS DATA 

5508
03:53:06,480 --> 03:53:09,720
TESTED FOR RISK ASSESSMENT IN 

5509
03:53:09,720 --> 03:53:10,600
THE POPULATION AND EXOSOME 

5510
03:53:10,600 --> 03:53:12,320
SECTION WHICH WOULD BE DEVOTED 

5511
03:53:12,320 --> 03:53:16,520
TO TRANSLATIONAL RESEARCH WHERE 

5512
03:53:16,520 --> 03:53:19,080
WE CAN ACTUALLY FOCUS ON ONE OR 

5513
03:53:19,080 --> 03:53:20,400
TWO CORE MECHANISMS AND LOOK AT 

5514
03:53:20,400 --> 03:53:24,920
HOW THE MECHANISMS AFFECT THE 

5515
03:53:24,920 --> 03:53:26,920
WHOLE PERSON AS WELL AS PROVIDE 

5516
03:53:26,920 --> 03:53:28,920
INFORMATION FOR TRANSLATIONAL 

5517
03:53:28,920 --> 03:53:29,760
RESEARCH AND THEN FINALLY 

5518
03:53:29,760 --> 03:53:34,600
CONTINUE WITH THE HEALTH 

5519
03:53:34,600 --> 03:53:36,440
DISPARITIES RESEARCH CONDUCTED 

5520
03:53:36,440 --> 03:53:39,960
BY DR. EVANS WHERE SHE'S TRYING 

5521
03:53:39,960 --> 03:53:41,520
TO DISENTANGLE THE RELATIONSHIPS

5522
03:53:41,520 --> 03:53:42,880
AMONG RACE, SOCIO ECONOMIC 

5523
03:53:42,880 --> 03:53:45,360
STATUS AND HEALTH OUTCOMES.

5524
03:53:45,360 --> 03:53:47,120
I WOULD ALSO LIKE TO EMPHASIZE 

5525
03:53:47,120 --> 03:53:51,040
THAT THE HEALTH DISPARITIES AS 

5526
03:53:51,040 --> 03:53:52,000
WELL AS METHODS DEVELOPMENT 

5527
03:53:52,000 --> 03:53:55,480
WOULD BE THEMES RUN THROUGH THE 

5528
03:53:55,480 --> 03:53:57,720
WHOLE RESEARCH CONDUCTED IN EACH

5529
03:53:57,720 --> 03:54:00,280
OF THE SECTIONS THAT WE ARE 

5530
03:54:00,280 --> 03:54:00,680
TRYING TO DEVELOP.

5531
03:54:00,680 --> 03:54:02,720
THE WORK WOULD BE BASED ON THE 

5532
03:54:02,720 --> 03:54:07,960
LEGACY COHORT S THAT WE HAVE AND

5533
03:54:07,960 --> 03:54:09,280
OVER TIME WE HOPE TO BE ABLE IT 

5534
03:54:09,280 --> 03:54:12,400
PLAN NEW STUDIES.

5535
03:54:12,400 --> 03:54:15,920
WITHIN THE INTRAMURAL RESEARCH 

5536
03:54:15,920 --> 03:54:17,920
ENVIRONMENT, I PERCEIVE LEPS TO 

5537
03:54:17,920 --> 03:54:20,040
BE THE CORE OF METHODS EXPERTISE

5538
03:54:20,040 --> 03:54:22,240
AS WELL AS COHORTS THAT WE'VE 

5539
03:54:22,240 --> 03:54:26,080
DEVELOPED THAT WOULD ALLOW 

5540
03:54:26,080 --> 03:54:28,320
COLLABORATION WITH MANY OF THE 

5541
03:54:28,320 --> 03:54:28,920
DIFFERENT LABORATORIES IN THE 

5542
03:54:28,920 --> 03:54:33,640
IRP.

5543
03:54:33,640 --> 03:54:34,840
 AS WELL AS PROVIDING 

5544
03:54:34,840 --> 03:54:39,640
OPPORTUNITY TO DEVELOP TRAIN JEZ

5545
03:54:39,640 --> 03:54:41,080
AND ACROSS DISCIPLINARY RESEARCH

5546
03:54:41,080 --> 03:54:44,920
AND WE WOULD ALSO STRENGTHEN OUR

5547
03:54:44,920 --> 03:54:46,960
CONNECTS WITH OTHER NIH 

5548
03:54:46,960 --> 03:54:48,360
INSTITUTES AS WELL AS NATIONALLY

5549
03:54:48,360 --> 03:54:51,320
AND INTERNATIONALLY AND CONTINUE

5550
03:54:51,320 --> 03:54:54,360
TO CONTRIBUTE TO THE CONSORTIUM 

5551
03:54:54,360 --> 03:54:55,040
WHICH ARE ESSENTIAL FOR RESEARCH

5552
03:54:55,040 --> 03:54:59,040
IN GENTICS.

5553
03:54:59,040 --> 03:55:02,320
-- GENETICS.

5554
03:55:02,320 --> 03:55:06,440
I'D LIKE TO END WITH ONE IDEA 

5555
03:55:06,440 --> 03:55:08,720
WE'VE BEEN DEVELOPING AND FUTURE

5556
03:55:08,720 --> 03:55:11,120
DIRECTION FOR THE LAB.

5557
03:55:11,120 --> 03:55:14,360
THIS WOULD BE STUDY IN LINE WITH

5558
03:55:14,360 --> 03:55:16,880
THE BSC RECOMMENDATION.

5559
03:55:16,880 --> 03:55:18,640
THE NEW RESOURCE IS STUDY THE 

5560
03:55:18,640 --> 03:55:20,880
EFFECT OF DISASTERS AND CLIMATE 

5561
03:55:20,880 --> 03:55:23,200
CHANGE ON OLDER PERSONS BROADLY 

5562
03:55:23,200 --> 03:55:27,000
WE SEE THREE PHASES TO THE 

5563
03:55:27,000 --> 03:55:29,280
TRAJECTORY OF THE DISASTER THE 

5564
03:55:29,280 --> 03:55:34,720
BASELINE, THE INTERIM PERIOD OR 

5565
03:55:34,720 --> 03:55:36,880
PERIOD TO SEE THE SEQUELAE OF 

5566
03:55:36,880 --> 03:55:42,400
THE DISASTER ON HEALTH AND LOOK 

5567
03:55:42,400 --> 03:55:45,200
AT SOMEBODY'S CURRENT HEALTH.

5568
03:55:45,200 --> 03:55:49,480
FOR THIS KIND OF STUDY WE WOULD 

5569
03:55:49,480 --> 03:55:52,440
RELY ON MULTIPLE DATA STREAMS OF

5570
03:55:52,440 --> 03:55:55,400
HISTORICALLY PUBLICLY AVAILABLE 

5571
03:55:55,400 --> 03:55:57,720
HEALTH, ENVIRONMENT, SOCIO 

5572
03:55:57,720 --> 03:55:58,320
ECONOMIC RECORDS AND PERHAPS 

5573
03:55:58,320 --> 03:56:00,920
ALSO CONDUCT A FACE TO FACE 

5574
03:56:00,920 --> 03:56:02,400
EXAMINE ON A PREVIOUSLY EXPOSED 

5575
03:56:02,400 --> 03:56:17,680
COHORT.

5576
03:56:17,680 --> 03:56:22,760
WE ARE LOOKING AT THE QUESTIONS 

5577
03:56:23,000 --> 03:56:24,400
TO OLD ER PERSONS THAT NEED TO 

5578
03:56:24,400 --> 03:56:27,480
BE ADDRESSED AND THE 

5579
03:56:27,480 --> 03:56:29,280
MEASUREMENTS AND RESOURCES 

5580
03:56:29,280 --> 03:56:32,480
AVAILABLE TO EVALUATE THE 

5581
03:56:32,480 --> 03:56:34,560
AFFECTS OF THE OLDER PERSONS AND

5582
03:56:34,560 --> 03:56:40,320
IS THERE A SPECIFIC PERSON ONE 

5583
03:56:40,320 --> 03:56:42,680
DUE TO WILDFIRE OR FLOODING OR 

5584
03:56:42,680 --> 03:56:46,240
DAMAGE WE SHOULD BE STUDYING IN 

5585
03:56:46,240 --> 03:56:46,640
PARTICULAR.

5586
03:56:46,640 --> 03:56:49,240
AND ONE OF THE BIOMARKERS THAT 

5587
03:56:49,240 --> 03:56:51,560
WOULD CHANGE AND HEALTH 

5588
03:56:51,560 --> 03:56:54,240
PARAMETERS THAT MIGHT REFLECT 

5589
03:56:54,240 --> 03:56:57,440
THE EFFECT THE DISASTER HAS ON 

5590
03:56:57,440 --> 03:56:59,840
HEALTH AND WHAT THE FEASIBILITY 

5591
03:56:59,840 --> 03:57:03,480
AND FUNDING TO MOUNT SUCH A 

5592
03:57:03,480 --> 03:57:03,680
STUDY.

5593
03:57:03,680 --> 03:57:07,720
THE STUDY COULD PROVIDE A 

5594
03:57:07,720 --> 03:57:10,280
PLATFORM FOR MANY DIFFERENT 

5595
03:57:10,280 --> 03:57:13,560
QUESTIONS RELATED TO SOCIAL AND 

5596
03:57:13,560 --> 03:57:16,960
PHYSIOLOGIC PROCESSES AND 

5597
03:57:16,960 --> 03:57:19,720
PROVIDE A MEANS FOR MORE 

5598
03:57:19,720 --> 03:57:20,800
TRANSLATIONAL AND 

5599
03:57:20,800 --> 03:57:22,480
MULTI-DISCIPLINARY RESEARCH AND 

5600
03:57:22,480 --> 03:57:28,760
WITH THAT I WILL END.

5601
03:57:28,760 --> 03:57:29,720
>> THANK YOU.

5602
03:57:29,720 --> 03:57:48,120
IF THERE IS ONE BRIEF QUESTION.

5603
03:57:48,120 --> 03:57:49,240
>> CAN YOU STOP SHARING?

5604
03:57:49,240 --> 03:58:02,920
>> SORRY.

5605
03:58:02,920 --> 03:58:44,280
>> CAN YOU SEE MY SCREEN?

5606
03:58:44,280 --> 03:58:48,120
>> THE TRANSLATIONAL GERONTOLOGY

5607
03:58:48,120 --> 03:58:50,680
BRANCH LOOKS TO SEE WHAT'S 

5608
03:58:50,680 --> 03:58:54,120
RESPONSIBLE FOR THE RELATED AGE 

5609
03:58:54,120 --> 03:58:56,880
DECLINE IN SPECIES AND DELAY THE

5610
03:58:56,880 --> 03:58:59,200
PROCESS IN USING MULTIPLE 

5611
03:58:59,200 --> 03:58:59,920
SPECIES.

5612
03:58:59,920 --> 03:59:02,160
WE TRY TO DESIGN AND EVALUATE 

5613
03:59:02,160 --> 03:59:05,920
NOVEL THERAPEUTICS IN NOVEL OF 

5614
03:59:05,920 --> 03:59:10,920
AGE AND IMPLICATIONS AND FOCUS 

5615
03:59:10,920 --> 03:59:16,040
ON FUNCTIONAL OUTCOMES IN TERMS 

5616
03:59:16,040 --> 03:59:20,760
OF MUSCLE FUNCTION AND TRIED TO 

5617
03:59:20,760 --> 03:59:30,880
MAKE THE DATA AVAILABLE AND 

5618
03:59:30,880 --> 03:59:36,400
RECRUIT AND DEVELOP THE NEXT 

5619
03:59:36,400 --> 03:59:39,880
GENERATION OF SCIENTISTS AND AND

5620
03:59:39,880 --> 03:59:42,160
GET TO PLACES WHERE THEY WANT TO

5621
03:59:42,160 --> 03:59:42,400
BE.

5622
03:59:42,400 --> 03:59:42,560
THE T 

5623
03:59:48,960 --> 03:59:51,960
 THIS WAS OUR SECOND EVALUATION 

5624
03:59:51,960 --> 03:59:52,280
AS A GROUP.

5625
03:59:52,280 --> 03:59:56,200
AT THAT TIME, THE EVALUATION IN 

5626
03:59:56,200 --> 04:00:05,400
2020 WE HAD NIGEL GRIG AND JULIE

5627
04:00:05,400 --> 04:00:12,520
MADISON AND MYSELF AND IT WAS A 

5628
04:00:12,520 --> 04:00:14,920
SUCCESSFUL VACCINATION OF THE 

5629
04:00:14,920 --> 04:00:18,160
BRANCH AS A WHOLE.

5630
04:00:18,160 --> 04:00:22,320
IN JANUARY 2022 I CAN REPORT THE

5631
04:00:22,320 --> 04:00:26,600
BRANCH HAS GROWN SUBSTANTIALLY 

5632
04:00:26,600 --> 04:00:30,280
AND WE HAD A TENURE TRACK 

5633
04:00:30,280 --> 04:00:32,240
INVESTIGATOR HITTING THE GROUND 

5634
04:00:32,240 --> 04:00:32,640
RUNNING.

5635
04:00:32,640 --> 04:00:35,480
WE HAVE AND THERE ARE SOME THAT 

5636
04:00:35,480 --> 04:00:37,480
BECAME THE ACTING CODIRECTOR OF 

5637
04:00:37,480 --> 04:00:41,920
THE STUDIO OF AGING AND THE MOVE

5638
04:00:41,920 --> 04:00:44,880
FROM THE LABORATORY ON MOLECULAR

5639
04:00:44,880 --> 04:00:48,400
GERONTOLOGY TO THE TRANSLATIONAL

5640
04:00:48,400 --> 04:00:50,560
GERONTOLOGY BRANCH.

5641
04:00:50,560 --> 04:00:52,880
WE TRIED TO INTEGRATE THE 

5642
04:00:52,880 --> 04:00:53,960
INFORMATION FROM THE ENVIRONMENT

5643
04:00:53,960 --> 04:00:55,280
AND HOW THESE THINGS INTERACT AT

5644
04:00:55,280 --> 04:00:57,680
THE LEVEL OF THE ORGANISM AND 

5645
04:00:57,680 --> 04:00:58,400
THE CELLULAR LEVEL.

5646
04:00:58,400 --> 04:01:02,040
AT THE CELLULAR LEVEL, WE KNOW 

5647
04:01:02,040 --> 04:01:04,000
ALL THE INFORMATION THAT COMES 

5648
04:01:04,000 --> 04:01:08,320
IN IS READ AT THE LEVEL OF THE 

5649
04:01:08,320 --> 04:01:12,520
BRAIN AND HOW WE TRIED TO 

5650
04:01:12,520 --> 04:01:16,520
UNDERSTAND HOW THIS INFORMATION 

5651
04:01:16,520 --> 04:01:17,600
GOES DOWN.

5652
04:01:17,600 --> 04:01:23,240
FROM THE PLASMA MEMBRANE THERE'S

5653
04:01:23,240 --> 04:01:30,440
CELLULAR MARKERS AND RESPOND TO 

5654
04:01:30,440 --> 04:01:34,000
THESE SIGNALS BY ACTIVATING THE 

5655
04:01:34,000 --> 04:01:38,680
SIGNALLING PATHWAYS.

5656
04:01:38,680 --> 04:01:44,000
THESE THEN AND IT'S CONNECT HEAD

5657
04:01:44,000 --> 04:01:46,320
TO HALLMARKS OF AGING AND WHAT 

5658
04:01:46,320 --> 04:01:49,720
WE'RE TRYING TO DO UNDERSTAND IS

5659
04:01:49,720 --> 04:01:52,160
HOW THESE MECHANISM OF HALLMARKS

5660
04:01:52,160 --> 04:01:57,320
THAT UNDER LIE THE PROCESS HAVE 

5661
04:01:57,320 --> 04:02:02,320
A DIRECT EFFECT ON THE 

5662
04:02:02,320 --> 04:02:05,880
PHENOTYPES AND UTILIZE ENERGY 

5663
04:02:05,880 --> 04:02:08,160
AND HOW WE LOOK AT THE SYSTEMS 

5664
04:02:08,160 --> 04:02:12,280
AND HOW THESE LEAD TO CHANGES IN

5665
04:02:12,280 --> 04:02:13,240
NEURODEGENERATION AND FUNCTIONAL

5666
04:02:13,240 --> 04:02:17,800
DECLINE AS A WHOLE AND BY 

5667
04:02:17,800 --> 04:02:18,920
ALTERING THE ENVIRONMENT AND HOW

5668
04:02:18,920 --> 04:02:23,760
CAN WE DEVELOP INTERVENTIONS 

5669
04:02:23,760 --> 04:02:28,920
THAT LEAD TO CHANGES IN 

5670
04:02:28,920 --> 04:02:38,800
RESILIENCE AND LONGEVITY?

5671
04:02:38,800 --> 04:02:40,800
IN THE REPORT ON THE SLIDE DECK 

5672
04:02:40,800 --> 04:02:42,400
YOU'LL HAVE A REPRESENTATION OF 

5673
04:02:42,400 --> 04:02:44,920
EVERY UNIT AND THE HITS WE'RE 

5674
04:02:44,920 --> 04:02:47,440
HAVING AND MAKE SURE YOU GET 

5675
04:02:47,440 --> 04:02:50,760
INSIGHT ON WHAT THE NEW TRAINEES

5676
04:02:50,760 --> 04:02:55,640
AND RECRUITS ARE GETTING AND 

5677
04:02:55,640 --> 04:03:00,480
WHAT OTHERS ARE DOING NOW.

5678
04:03:00,480 --> 04:03:03,320
THERE'S NOW A PROTEOMICS UNIT 

5679
04:03:03,320 --> 04:03:06,600
WITHIN THE STUDY SECTION AND HIS

5680
04:03:06,600 --> 04:03:07,760
RECENT DIRECTIONS ARE IN THE 

5681
04:03:07,760 --> 04:03:08,920
DEVELOPMENT OF THE NEXT 

5682
04:03:08,920 --> 04:03:11,480
GENERATION OF AGING BIOMARKERS 

5683
04:03:11,480 --> 04:03:16,280
WITH A FOCUS ON PROTEOMICS AND 

5684
04:03:16,280 --> 04:03:21,280
SPECIFICALLY STUDYING SENESCENT 

5685
04:03:21,280 --> 04:03:24,920
IN VIVO AND IN VITRO AND 

5686
04:03:24,920 --> 04:03:26,240
INTEGRATED WITH THE NIH FAMILY 

5687
04:03:26,240 --> 04:03:30,760
AND THE STUDY OF AGING IS 

5688
04:03:30,760 --> 04:03:32,480
INTEGRATED WITH THE PROJECT 

5689
04:03:32,480 --> 04:03:36,440
WITHIN MY UNIT, MY SECTION AND 

5690
04:03:36,440 --> 04:03:39,400
LOOKING AT THE NON-HUMAN 

5691
04:03:39,400 --> 04:03:39,840
PRIMATE.

5692
04:03:39,840 --> 04:03:43,400
HE'S ALSO LOOKING AT HOW PROTEIN

5693
04:03:43,400 --> 04:03:46,640
TURNOVER CHANGES OVER TIME IN 

5694
04:03:46,640 --> 04:03:47,680
LONGITUDINAL STUDIES OF AGING 

5695
04:03:47,680 --> 04:03:52,360
AND WHAT ARE THE DIFFERENT WAYS 

5696
04:03:52,360 --> 04:03:54,120
HE CAN DEVELOP AND EVALUATE 

5697
04:03:54,120 --> 04:03:59,760
NOVEL MARKERS OF SENESCENCE AND 

5698
04:03:59,760 --> 04:04:01,120
BIOMARKERS ACROSS THE LIFE SPAN.

5699
04:04:01,120 --> 04:04:07,800
HE HAS BEEN ALREADY BEEN ABLE TO

5700
04:04:07,800 --> 04:04:09,920
IDENTIFY AND HIRE SEVERAL 

5701
04:04:09,920 --> 04:04:11,120
TRAINEES AND HAS HIT THE GROUND 

5702
04:04:11,120 --> 04:04:12,240
RUNNING IN TERMS OF GRANTS.

5703
04:04:12,240 --> 04:04:20,200
HE WAS ALREADY AWARDED TO STUDY 

5704
04:04:20,200 --> 04:04:24,880
A COMPOUND IN TERMS OF THE GRANT

5705
04:04:24,880 --> 04:04:27,120
THAT WILL GIVE HIM FOR OVER FOUR

5706
04:04:27,120 --> 04:04:33,360
YEARS FOCUSSED ON SENESCENCE.

5707
04:04:33,360 --> 04:04:36,360
ONE OF THE THINGS IS HE'S A 

5708
04:04:36,360 --> 04:04:39,680
LEADER IN THE DEVELOPMENT OF NEW

5709
04:04:39,680 --> 04:04:42,240
PROTEOMICS MARKERS AND AUTHORED 

5710
04:04:42,240 --> 04:04:47,880
THE PAPER IN 2020 HE DEVELOPED 

5711
04:04:47,880 --> 04:04:56,120
THE ASSOCIATE D SYMPTOMS AND
HE'S

5712
04:04:56,120 --> 04:04:57,280
LOOKING AT THE ASSOCIATION 

5713
04:04:57,280 --> 04:05:02,720
BETWEEN THE MARKERS IN 

5714
04:05:02,720 --> 04:05:08,720
ASSOCIATION WITH MORTALITY 

5715
04:05:08,720 --> 04:05:10,520
MARKERS AND THE OUTCOMES OF 

5716
04:05:10,520 --> 04:05:13,960
HEALTH AND SURVIVAL AND LOOKING 

5717
04:05:13,960 --> 04:05:18,360
AT HOW THE AGING PROCESS CHANGES

5718
04:05:18,360 --> 04:05:20,760
THE PROTEINS AT THE LEVEL OF THE

5719
04:05:20,760 --> 04:05:23,480
PLASMA MEMBRANE AND ALL THIS IN 

5720
04:05:23,480 --> 04:05:25,120
THE CONTEXT OF SENESCENT CELLS.

5721
04:05:25,120 --> 04:05:36,160
FLOU WE HAVE -- NOW WE HAVE THE 

5722
04:05:36,160 --> 04:05:40,480
PAPERS LINED UP AND STARTING TO 

5723
04:05:40,480 --> 04:05:41,640
GET PUBLISHED.

5724
04:05:41,640 --> 04:05:44,480
SHE HAS RECENTLY HIRED TWO NEW 

5725
04:05:44,480 --> 04:05:47,200
TRAINEES AND HAS BEEN GETTING 

5726
04:05:47,200 --> 04:05:48,480
AWARDS AS A PERSON AND ALSO MOST

5727
04:05:48,480 --> 04:05:51,320
OF HER TRAINEES HAVE BEEN 

5728
04:05:51,320 --> 04:05:53,920
EXTREMELY SUCCESSFUL GETTING 

5729
04:05:53,920 --> 04:05:56,160
AWARDS AS WELL AS GRANTS FROM 

5730
04:05:56,160 --> 04:05:58,440
BOTH SCIENTIFIC DIRECTOR OF 

5731
04:05:58,440 --> 04:06:08,560
AWARDS AND THE RFA WITH NIA AND 

5732
04:06:08,560 --> 04:06:10,680
NIEHS AND IN A PAPER PUBLISHED 

5733
04:06:10,680 --> 04:06:16,880
WITH THE MECHANISM OF DISEASE 

5734
04:06:16,880 --> 04:06:24,880
WAS THE POTENTIAL OF ATM 

5735
04:06:24,880 --> 04:06:28,800
NEGATIVE KNOCKOUT AND BASICALLY 

5736
04:06:28,800 --> 04:06:34,360
IF YOU SUPPLEMENT MICE AND LOOK 

5737
04:06:34,360 --> 04:06:36,400
AT THE BALANCED LINEAGE YOU SEE 

5738
04:06:36,400 --> 04:06:38,440
IT DOESN'T REALLY PRODUCE ANY 

5739
04:06:38,440 --> 04:06:43,520
CHANGES BUT WHEN YOU DO THIS 

5740
04:06:43,520 --> 04:06:44,880
WITH OLD WILD TYPE ANIMALS CAN 

5741
04:06:44,880 --> 04:06:48,400
SEE THERE'S AN OVERLOAD AND 

5742
04:06:48,400 --> 04:07:00,440
SUPPLEMENT THE ANIMALS WITH THE 

5743
04:07:00,440 --> 04:07:01,960
LONG-TERM AFFECTS TO SEE WHAT 

5744
04:07:01,960 --> 04:07:04,880
THE OUTCOMES WOULD BE WITH 

5745
04:07:04,880 --> 04:07:07,720
LONG-TERM TREATMENTS.

5746
04:07:07,720 --> 04:07:11,480
LAST ON THE LIST, THE CHIVE OF 

5747
04:07:11,480 --> 04:07:16,280
THE GENOMIC SECTION MOVING TO 

5748
04:07:16,280 --> 04:07:18,440
THE TRANSLATIONAL GERONTOLOGY 

5749
04:07:18,440 --> 04:07:24,360
BRANCH HAS BEEN ABLE TO RECRUIT 

5750
04:07:24,360 --> 04:07:25,640
OR INHERIT SOME PEOPLE TO HIS 

5751
04:07:25,640 --> 04:07:30,360
NEW GROUP AND CONTINUES TO BE 

5752
04:07:30,360 --> 04:07:32,480
EXTREMELY ACTIVE WITH THE 

5753
04:07:32,480 --> 04:07:34,920
GENOMIC INTEGRATE AND PUBLISHED 

5754
04:07:34,920 --> 04:07:40,480
A PAPER IN NATURE COMMUNICATIONS

5755
04:07:40,480 --> 04:07:44,560
LOOKING AT TCOMBATTING CANCER
AND

5756
04:07:44,560 --> 04:07:55,360
USED AN APPROACH OF TARGETING 

5757
04:07:55,360 --> 04:08:02,400
THE CELLS AND YOU CAN SEE WHEN 

5758
04:08:02,400 --> 04:08:06,920
HE USED BRCA 2 DEFICIENT MICE 

5759
04:08:06,920 --> 04:08:09,640
THEY EXHIBIT AN INCREASED GROWTH

5760
04:08:09,640 --> 04:08:12,440
INHIBITION WHEN TREATED WITH THE

5761
04:08:12,440 --> 04:08:14,600
INHIBITOR.

5762
04:08:14,600 --> 04:08:16,920
THIS S A NEW LINE OF 

5763
04:08:16,920 --> 04:08:19,160
INVESTIGATIONS HE'LL BE LOOKING 

5764
04:08:19,160 --> 04:08:20,920
AT THE DIFFERENT METERS AND HOW 

5765
04:08:20,920 --> 04:08:22,160
THEY INTERACT IN TUMOR CANCER 

5766
04:08:22,160 --> 04:08:30,400
GROWTH.

5767
04:08:30,400 --> 04:08:33,240
THE TRANSLATIONAL GERONTOLOGY 

5768
04:08:33,240 --> 04:08:36,640
BRANCH IS CONNECTED TO DIFFERENT

5769
04:08:36,640 --> 04:08:40,320
UNIVERSITIES THE U.S. AND THE 

5770
04:08:40,320 --> 04:08:41,320
WORLD.

5771
04:08:41,320 --> 04:08:44,320
WE REMAIN A CORE CENTER OF 

5772
04:08:44,320 --> 04:08:46,720
INTERACTION WITH HUGE 

5773
04:08:46,720 --> 04:08:48,920
INTEGRATIVE PROJECTS AND THIS IS

5774
04:08:48,920 --> 04:08:52,520
ONE OF THEM AND ALL THE 

5775
04:08:52,520 --> 04:08:54,400
INVESTIGATORS WITHIN THE 

5776
04:08:54,400 --> 04:08:55,000
INVESTIGATIONAL GERONTOLOGY 

5777
04:08:55,000 --> 04:08:57,520
BRANCH HAVE CONNECTIONS WITH 

5778
04:08:57,520 --> 04:09:02,080
MULTIPLE UNIVERSITIES ACROSS THE

5779
04:09:02,080 --> 04:09:11,800
U.S. INCREASING THE WE DO HERE.

5780
04:09:11,800 --> 04:09:14,920
THIS IS THE GOAL FROM 2017 TO 

5781
04:09:14,920 --> 04:09:15,120
2019.

5782
04:09:15,120 --> 04:09:17,440
THIS IS WHAT WAS PRESENTED TO 

5783
04:09:17,440 --> 04:09:20,920
THE BOARD OF SCIENTIFIC 

5784
04:09:20,920 --> 04:09:22,960
COUNSELORS IN 2020.

5785
04:09:22,960 --> 04:09:26,120
IN THE SPAN OF YEARS WE 

5786
04:09:26,120 --> 04:09:27,560
PUBLISHED 276 ARTICLES AND LOTS 

5787
04:09:27,560 --> 04:09:31,720
OF THEM WERE IN THE TOP 20% 

5788
04:09:31,720 --> 04:09:35,200
ARTICLES OF OUR RESEARCH.

5789
04:09:35,200 --> 04:09:37,480
RIGHT NOW THE OTHER DAY WITH THE

5790
04:09:37,480 --> 04:09:40,600
IMPACT OF THE 2020 IN THIS TWO 

5791
04:09:40,600 --> 04:09:44,880
YEARS WE HAVE ALREADY PUBLISHED 

5792
04:09:44,880 --> 04:09:48,000
242 PAPERS AND THIS IS MORE THAN

5793
04:09:48,000 --> 04:09:51,280
10,000 CITATIONS AND YET TOO 

5794
04:09:51,280 --> 04:09:53,280
EARLY TO SAY HOW MANY PAPERS 

5795
04:09:53,280 --> 04:09:57,120
WILL END UP TOP FOUR CITATIONS.

5796
04:09:57,120 --> 04:09:59,680
IT REMAINS PRODUCTIVE AND 

5797
04:09:59,680 --> 04:10:01,560
CONNECTED AND CONTINUE TO 

5798
04:10:01,560 --> 04:10:06,880
INCREASE THE NUMBER OF 

5799
04:10:06,880 --> 04:10:09,920
INTERACTION BETWEEN INTRAMURAL 

5800
04:10:09,920 --> 04:10:11,320
AND EXTRAMURAL RESEARCHERS 

5801
04:10:11,320 --> 04:10:14,960
REMAINING ACCESS AND THE DATA WE

5802
04:10:14,960 --> 04:10:18,480
HAVE PRODUCING.

5803
04:10:18,480 --> 04:10:20,520
YOU SEE THE PAPER AND GRANTS AND

5804
04:10:20,520 --> 04:10:22,320
AWARDS AND FELLOWSHIPS WE'RE ALL

5805
04:10:22,320 --> 04:10:23,920
GETTING AND THIS IS ALL OF US 

5806
04:10:23,920 --> 04:10:30,880
NOT JUST A FEW OF US WITHIN AND 

5807
04:10:30,880 --> 04:10:33,920
BENEATH THE SURFACE THERE'S A 

5808
04:10:33,920 --> 04:10:36,360
LOT OF THINGS THAT GO UNSEEN.

5809
04:10:36,360 --> 04:10:37,840
THERE'S MULTIPLE PEOPLE THAT 

5810
04:10:37,840 --> 04:10:40,080
CONTRIBUTE TO THE SUCCESS OF THE

5811
04:10:40,080 --> 04:10:42,320
TRANSLATIONAL GERONTOLOGY BRANCH

5812
04:10:42,320 --> 04:10:45,880
AND A PICTURE OF THE CURRENT 

5813
04:10:45,880 --> 04:10:47,320
MEMBERS AND WE CANNOT BE 

5814
04:10:47,320 --> 04:10:48,920
TOGETHER THANKS TO COVID BUT I 

5815
04:10:48,920 --> 04:10:52,120
HOPE VERY SOON WE'LL ABLE TO GET

5816
04:10:52,120 --> 04:10:54,840
A CELEBRATION TO THE SUCCESS 

5817
04:10:54,840 --> 04:10:56,440
TGB2020 TO PREPARE FOR THE NEXT 

5818
04:10:56,440 --> 04:10:58,800
ONE COMING UP IN 2024.

5819
04:10:58,800 --> 04:11:00,480
I'M HAPPY TO ACHE ANY QUESTIONS 

5820
04:11:00,480 --> 04:11:19,040
YOU MAY HAVE.

5821
04:11:19,040 --> 04:11:21,160
>> ARE YOU INTERACTING WITH THE 

5822
04:11:21,160 --> 04:11:24,160
COMMON FUND INITIATIVE AND IF 

5823
04:11:24,160 --> 04:11:24,920
SO, HOW?

5824
04:11:24,920 --> 04:11:28,280
>> THAT'S A FANTASTIC QUESTION.

5825
04:11:28,280 --> 04:11:34,320
WE JUST SUBMITTED A U54 PROPOSAL

5826
04:11:34,320 --> 04:11:41,840
THAT WAS AN RFA FROM THE SUNMET 

5827
04:11:41,840 --> 04:11:52,880
DEDICATED TO THE MOUSE WE HAVE A

5828
04:11:52,880 --> 04:12:03,120
CON -- CONSORTIA FROM THE MAYO 

5829
04:12:03,120 --> 04:12:05,440
CLINIC AND WE WELCOME THE PEOPLE

5830
04:12:05,440 --> 04:12:10,840
THAT WERE SUCCESSFUL IN SECURING

5831
04:12:10,840 --> 04:12:13,320
THE HUMAN SENESCENCE.

5832
04:12:13,320 --> 04:12:15,600
WE'RE INTEGRATING OR TRYING TO 

5833
04:12:15,600 --> 04:12:16,120
BE INTEGRATED AS MUCH AS 

5834
04:12:16,120 --> 04:12:24,160
POSSIBLE.

5835
04:12:24,160 --> 04:12:28,200
>> LUIGI, ANY FINAL REMARKS 

5836
04:12:28,200 --> 04:12:29,880
BEFORE WE END THE CLOSED 

5837
04:12:29,880 --> 04:12:31,720
SESSION.

5838
04:12:31,720 --> 04:12:33,440
>> THANK YOU FOR TRE 

5839
04:12:33,440 --> 04:12:33,760
PRESENTATION.

5840
04:12:33,760 --> 04:12:37,280
YOU CAN SEE WHAT A GOOD POSITION

5841
04:12:37,280 --> 04:12:40,840
I AM WORKING WITH FANTASTIC, 

5842
04:12:40,840 --> 04:12:42,920
PRODUCTIVE CREATIVE SCIENTISTS.

5843
04:12:42,920 --> 04:12:43,400
I COULDN'T ASK FOR MORE.

5844
04:12:43,400 --> 04:12:49,080
THANK YOU VERY MUCH.

5845
04:12:49,080 --> 04:12:52,880
>> THANK YOU TO OUR SPEAKERS IN 

5846
04:12:52,880 --> 04:12:54,440
THE INTERMURAL PROGRAM.

5847
04:12:54,440 --> 04:12:57,320
THIS THEN CONCLUDES THE OPEN 

5848
04:12:57,320 --> 04:12:58,560
SESSION OF OUR NATIONAL ADVISORY

5849
04:12:58,560 --> 00:00:00,000
COUNCIL ON AGING.