WELCOME TO THE 296th MEETING
OF THE NATIONAL HEART LUNG AND
BLOOD ADVISORY COUNCIL.
AND WITH THIS, WE HAVE NOW
CONVENED THIS, ON FICIALLY AND
BROUGHT THIS MEETING TO ORDER
AND NOW TURN IT OVER TO OUR
EXECUTIVE SECRETARY.
DR. LAURA MOEN.
>> SO THANK YOU DR. GIBBONS.
WELCOME EVERYBODY, I WOULD LIKE
TO CALL THIS OPEN SESSION TO
ORDER AS DR. GIBBONS ALREADY
SAID.
I WANT TO REMIND YOU THAT WE DID
ADVERTISE THIS MEETING IN THE
FEDERAL REGISTER AND I ALSO WANT
TO REMIND OUR COUNCIL MEMBERS
WE'RE NOW IN OPEN SESSION SO
REMEMBER WE ARE BEING WEBCAST AS
WELL AS RECORDED.
VIDEO WILL BE ARCHIVED AND
REMAIN AVAILABLE TO THE PUBLIC
AND OUR NIH COLLEAGUES.
TO GIVE YOU A BRIEF OVERVIEW OF
THIS AFTERNOON'S AGENDA, WELL,
THIS MORNING AND AFTERNOON, THE
MEETING IS GOING BEGIN WITH THE
DIRECTOR'S REPORT FROM
DR. GIBBONS FOLLOWED BY COUPLE
OF PRESENTATIONS.
THE FIRST OF THESE
PRESENTATIONS--CLIMATE CHANGE
AND HEALTH EQUITY.
THEN WE WILL HEAR FROM DR. GAIL
PEARSON AND THE DIVISION OF
CARDIOVASCULAR SCIENCES AND
DIRECTOR OF OFFICE OF CLINICAL
RESEARCH AND THE DIRECTOR OF
NHLBI, AS WELL AS MISS KATHRYN
[INDISCERNIBLE] INCLUDING
UNDERREPRESENTED GROUPS AND
NHLBI CLINICAL RESEARCH.
AND LAST BUT NOT LEAST WE WILL
ENGAGE IN DISCUSSION OF THE
DELEGATION OF AUTHORITY FOLLOWED
BY ADJOURNMENT.
SO, AS WE PROCEED WITH OPEN
SESSION, YOU KNOW TAKE A BREAK
IF YOU NEED 1, BUT REMEMBER WE
WILL BE HAVING A WORKING LUNCH,
SO IF YOU NEED A BIOBREAK OR YOU
NEED TO DART OUT FOR A SECOND
BUT DO NOT DISCONNECT FROM THE
ZOOM MEETING.
WITH THAT I THINK WE SHOULD GET
STARTED.
DR. GIBBONS WE MAY PROCEED WITH
YOUR REPORT WHENEVER YOU ARE
READY.
>> OKAY, GREAT.
THANK YOU DR. MOEN, IF I COULD
HAVE MY SLIDES, PLEASE, THANK
YOU.
NEXT SLIDE, PLEASE.
SO THE FIRST SEGMENT OF OUR
ACCOUNTABLE STEWARDSHIP IS TO
PROVIDE AN UPDATE TO THE
ADVISORY COUNCIL IN OUR
COMMUNITY OF A COUPLE OF
LEADERSHIP TRANSITIONS, THESE
ARE ALWAYS EXTREMELY BITTER
SWEET.
THE FIRST IS DR. ROBERT BALABAN
WHO IS OUR SCIENTIFIC DIRECTOR
LEADING OUR DIVISION OF
INTRAMURAL RESEARCH AS PART OF
THE OVERALL NIH INTRAMURAL
RESEARCH PROGRAM.
DR. BALABAN HAS BEEN THE
SCIENTIFIC DIRECTOR FOR ABOUT 20
YEARS NOW AND HE HAS BEEN
EXEMPLARY IN THAT POSITION
FOLLOWING A LONG TRADITION OF
GREAT SCIENTIFIC DIRECTORS AT
THE NHBBI.
AND WE HAS REACHED THAT POINT
WHERE HE WOULD LIKE TO STEP AWAY
FROM HIS LEADERSHIP
RESPONSIBILITIES TO GO BACK TO
THE LAB FOR A WHILE AND WE HAVE
GRUDGINGLY GRANTED THAT REQUEST.
WE CERTAINLY WILL MISS HIS FINE
LEADERSHIP AND HIS MARK AND
LEGACY ON THE DIR IS SOMETHING
THAT'S INDELIBLE.
HE'S LEFT US WITH A VERY VIBRANT
GROUP OF 60 FACULTY PLUS, A
200 MILLION-DOLLAR PLUS PROGRAM
THAT'S OUTSTANDING IN THE WORLD
LINKED TO THE WORLD'S LARGEST
RESEARCH HOSPITAL DOING LEADING
EDGE WORK AND WE'RE SO
APPRECIATIVE OF HIS LEADERSHIP.
ANOTHER DEPARTURE SOMEONE WHO'S
ALREADY GONE, KATHRYN STONE, THE
DEPUTY OF CITRIS, SO WE
APPRECIATE HER SERVICES WELL,
STEPPING IN TO CONTINUE TO SET A
PATHWAY FOR THIS NEW UNIT,
RELATIVELY NEW UNIT OF THE
INSTITUTE AND THE CENTER FOR
TRANSLATIONAL RESEARCH AND
IMPLEMENTATION SCIENCE UNDER
DR. MENSA.
SO WE APPRECIATE BOTH THOSE
PUBLIC SERVANTS FOR THEIR
SUPERLATIVE CONTRIBUTIONS TO THE
INSTITUTE AND OUR MISSION.
I MAY ALSO MENTION, MAYBE A
COMMERCIAL NOTE THAT BOTH THESE
SEARCHES ARE OPEN, I BELIEVE NOW
OFFICIALLY, BOTH FOR THE
SCIENTIFIC DIRECTOR AS WELL AS
THE DEPUTY DIRECTOR OF CTRIS SO
WE INVITE QUALIFIED APPLICANTS
IN THIS INCLIEWZIVE PROCESS.
NEXT SLIDE, PLEASE.
IN ADDITION AS EXTENSION OF
THOSE LEADERSHIP TRANSITIONS,
AGAIN, THE MANY BITTER SWEET
ELEMENTS TO THIS, IS LIKELY TO
BE THE SWAN SONG I WOULD THINK
FOR DR. KEITH HOOTS AS THE
DIVISION OF BLOOD DISEASES AND
RESOURCES DIRECTOR.
AND KEITH HAS SERVED US SO
SUPERBLY OVER THE LAST 13ISH
YEARS AND HAS A REMARKABLE
LEGACY OF ACHIEVEMENT AS THE
DIVISION DIRECTOR, THE BLOOD
DIVISION, AND WE BID HIM WELL AS
HE SETS OFF ON A NEXT CHAPTER
AND APPRECIATE HIS SERVICE 1 OF
HIS SORT OF FINAL DUTIES OF
EXCELLENCE WAS TO RECRUIT A
TERRIFIC DEPUTY FOR THE BLOOD
DIVISION, DR. JULIE P A NEPINTO,
AND WE ARE DELIGHTED--LATER THIS
SPRING.
SO AGAIN, BOTH A FAREWELL, AND A
WELCOME TO THE LEADERSHIP.
NEXT SLIDE, PLEASE.
MORE OVER, 1 TO ALSO CELEBRATE
WITH ALL OF YOU COLLECTIVELY THE
2022 AMERICAN HEART MONTH WHICH
HAS A THEME OF TAKING THE STRESS
OUT OF HEART HEALTH AND IN THE
MIDST OF THIS PANDEMIC, I THINK
WE COULD ALL USE SOME STRESS
RELIEF AND YOU MIGHT NOTICE FROM
MY VIRTUAL BACKGROUND THAT WE'RE
ALL CELEBRATING THIS MONTH
TOGETHER, PROBABLY HARD TO
DISCERN ON ZOOM BUT THERE ARE
ACTUALLY LITTLE RED STRIPES IN
MY SHIRT AND INVITE YOU ALL TO
GET IN THE SPIRIT OF THIS
INITIATIVE, DR. GOFF, IS OFTEN
OUR FLAG BEARER HERE AND WE
INVITE YOU TO JOIN IN ON THE
SOCIAL MEDIA CAMPAIGN TO AGAIN
RAISE AWARENESS THAT HEART
DISEASE IS CLEARLY THE NUMBER 1
KILLER OF MEN AND WOMEN IN THIS
COUNTRY AND THIS IS AN
OPPORTUNITY TO REALLY RAISE THAT
AWARENESS AND TRIGGER HOPEFULLY
ACTION TOWARD FOLKS TO LIVE A
HEART HEALTHIER LIFESTYLE.
NEXT SLIDE, PLEASE.
SO THOSE ARE SOME OF THE
COMMENTS OF OUR ACCOUNTABLE
LEADERSHIP.
NEXT SLIDE.
AND LEADERSHIP TRANSITIONS, LET
ME GIVE YOU A SENSE OF OUR
FISCAL STEWARDSHIP AND HERE YOU
CAN SEE WHERE WE HOPEFULLY ARE
WITH OUR APPROPRIATIONS PROCESS.
MANY OF YOU ARE AWARE THAT WE
REMAIN UNDER A CONTINUING
RESOLUTION FROM CONGRESS WHICH
BASICALLY MEANS THAT WE ARE
FUNDED AT THE LEVEL OF FY21 AND
WE'RE LOOKING FORWARD TO AN
APPROPRIATION THIS YEAR.
USUALLY THESE ARE SUPPOSED TO
GET YOUR BUDGET OCTOBER 1 BUT AS
IS THE NATURE OF CONGRESS WE'RE
ALMOST THROUGH THE FISCAL YEAR
AND WE WE'RE STILL AWAITING A
BUDGET.
WE ARE SOME ENCOURAGED BY THE
FACT THAT THEY'VE DONE SOME
MARKED UP SOME SORT OF ROUGH
DRAFTS IF YOU WILL AND BOTH ON
THE HOUSE AND THE SENATE SIDE.
IT DOES--IT APPEARS WE CHRONIC
LIVER DISEASE BE IN FOR A PLUS
UP WHICH WOULD BE VERY WELCOME
OVER OUR FY21 BUDGET WHICH WAS
PRETTY TIGHT AND I JUST WANT TO
BRING TO YOUR ATTENTION THERE
WERE A NUMBER OF ELEMENTS IN THE
OVERALL NIH BUDGET AND
PARTICULARLY GERMANE TO
PRESENTATION YOU WILL BE HEARING
TODAY WAS SOME LANGUAGE
INDICATING THAT THE FY22
APPROPRIATIONS WOULD INCLUDE
FUNDING FOR CLAIMATE CHANGE IN
HEALTH THAT APPEARS TO BE ABOUT
100 MILLION BOTH IN THE HOUSE
AND SENATE VERSIONS.
AGAIN, WE WILL HAVE TO WAIT AND
SEE HOW IT ALL WORKS OUT AND
MANY OF YOU ARE AWARE THAT
LITERALLY I THINK THE
APPROPRIATES ARE MEETING ALMOST
EVERY DAY FOR THE LAST WEEK OR
SO AND THIS WEEK, I BELIEVE A
BILL MAY BE FLOATING AROUND THE
HOUSE TO AT LEAST EXTEND THE C.
R. TO MIDMARCH WITH THE HOPE
THAT WE'LL REALLY GET AN
APPROPRIATION BY MARCH AND
HOPEFULLY JUMP START WHICH COULD
BE AN EXCITING PROGRAM IN
CLIMATE CHANGE, I THINK IS
RELEVANT TO THE NHBBI PORTFOLIO
AND YOU WILL HEAR MORE ABOUT
THAT.
SIMILARLY THERE IS LANGUAGE IN
THE 22 MARK UPS, 1 ON MATERNAL
MORBIDITY AND MORTALITY, AN AREA
THAT IS IMPORTANT TO THE NHLBI
PORTFOLIO AND SOME OF THE
INITIATIVES THAT YOU'RE VIEWING
TODAY, AS WELL AS A MAJOR
INVESTMENT IN NIH HEALTH
DISPARITIES RESEARCH PORTFOLIO
AND AGAIN, SOMETHING THAT
INTERSECTS THE LINES WITH NHLBI
PRIORITIES.
I JUST WANT TO BRING THAT TO
YOUR ATTENTION.
NEXT SLIDE, PLEASE.
SORT OF IN THAT SAME LINE, WE'VE
HAD YOU AND BE AS PART OF A
RETREAT SEVERAL MONTHS AGO IN
WHICH WE DID MORE OF A STEP BACK
AND DEEP DIVE INTO OUR CLINICAL
TRIAL RESEARCH PORTFOLIO AND WE
APPRECIATE THE INSIGHTS GIVEN
DURING THOSE SESSIONS AND AS
SORT OF A FOLLOW-UP TO THAT WE
WANTED TO GIVE YOU SOME SENSE OF
THE INSTITUTES TRENDS IN
INVESTMENTS--THAT BRING GREATER
CLEARANCE TO OUR PORTFOLIO,
CLEAR GREATER MILESTONES AND AS
WELL AS PROVIDE A MEANS ACTUALLY
OF BETTER TRACKING, OUR
INVESTMENTS AND SO, ON THE RIGHT
HAND PANEL, I THINK YOU CAN SEE
HOW WE'VE TRIED TO RECOGNIZE THE
GREAT OPPORTUNITY AND IMPORTANCE
OF OUR CLINICAL TRIAL PORTFOLIO.
AND TO FURTHER ENHANCE THOSE
INVESTMENTS.
SO HERE YOU CAN SEE A SWEEP OF
ABOUT 10 YEARS ABOUT WHERE WE'VE
BEEN, WHERE WE ARE NOW, AND
BASED ON THE TRENDS OF
APPROPRIATIONS, WHERE WE'RE
HEADED AND HOPEFULLY IT'LL
APPRECIATE THAT THERE'S AN
UPWARD CURVE TO THAT TREND AS
APPROPRIATIONS HAVE ALLOWED US
AND SO THIS IS AN AREA THAT
WE'RE VERY EXCITED ABOUT, WHERE
WE THINK WE CAN SUPPORT CLINICAL
TRIALS THAT HAVE AN IMPACT ON
PATIENT CARE AND ENLIGHTEN AND
ENHANCE GUIDELINES AS WELL AS
PROVIDE MECHANISTIC INSIGHTS
INTO DISEASE THAT WE HOPE WILL
LEAD TO DYNAMIC NEW TREATMENTS.
BUT AGAIN, I WANT TO GIVE YOU
THAT TRIM LINE THAT OUR BUDGET
MODEL REALLY SUPPORTS GROWING
INVESTMENTS IN THIS SPACE.
NEXT SLIDE, PLEASE.
SIMILARLY, I WANT TO GIVE YOU A
SIMILAR TREND VIEW OF SOME OF
OUR ACCOUNTABLE STEWARDSHIP
RELATED TO THE BIOMEDICAL
WORKFORCE.
YOU'VE SEEN AT VARIOUS COUNCILS
WE GUF YOU A SINGLE YEAR SHOT
AND SLICE OF THIS DATA BUT
THOUGHT WE WOULD TAKE MORE OF A
TREND VIEW IN THIS OCCASION AND
YOU CAN SEE SEX-GENDER
DEMOGRAPHICS ACROSS THE VARIOUS
MECHANISMS AND WHICH YOU CAN SEE
CERTAIN FOR SEX GENDER THAT AS
YOU MOVE KIND OF EARLIER ON FROM
OUR ESTABLISHED R01
INVESTIGATORS, WHERE WE STILL
HAVE CHALLENGES IN TERMS OF
PARITY THAT THE ESIs IS MORE
INCLUSIVE AND DIVERSE AS ARE
TRAINING ELEMENTS BY SEX AND
GENDER.
WE'RE GETTING CLOSE TO PARITY.
NEXT SLIDE, PLEASE.
THIS GIVES YOU AGAIN BECAUSE OF
THE SMALL NUMBERS A TREND OF
OUR--MADE UNDER REPRESENTED
GROUPS IN BIOMEDICAL WORKFORCE
AND HOW THAT'S LOOKING ACROSS
THE MECHANISMS.
SO HOPEFULLY THIS TREND DATA
GIVES YOU A SENSE OF THIS
PARTICULARLY GIVEN THAT THESE
ARE SMALL NUMBERS.
NEXT SLIDE, PLEASE.
SO THOSE ARE KIND OF THE
STEWARDSHIP COMPONENTS THAT WE
WANT TO SHARE AND THEN WE PIVOT
TO SOME OF OUR SCIENTIFIC
PRIORITIES THAT WE WANT TO
HIGHLIGHT ON THIS SESSION AND
AGAIN, IN KEEPING WITH OUR THEME
ON THE IMPACT OF CLIMATE CHANGE
ON PUBLIC HEALTH, CERTAINLY IN
VULNERABLE POPULATIONS.
AND AGAIN, I DON'T NEED TO TELL
THIS ASTUTE AUDIENCE WHAT WE'RE
SEEING IN THE CHANGES IN OUR
PLANET.
WHICH IS RELATED TO HUMAN
ACTIVITY THAT'S GOING TO BE
CHARACTERIZED BY PRIZING
TEMPERATURES, AND MORE EXTREME
WEATHER AND CHANGES THAT
THREATEN CERTAIN AREAS OF THE
GLOBE, PARTICULARLY RISING SEA
LEVELS AND DROUGHTS, ET CETERA.
AND ALL THAT VULNERABILITIES
THAT WE NEED TO BE SENSITIVE TO
THAT.
CERTAINLY TO THESE EXTREMES,
PERHAPS TO THE 2 TALES OF THE
AGE DISTRIBUTION, THE VERY YOUNG
AND THE VERY OLD AND THOSE WHO
ARE QUITE FRANKLY AFFECTED BY
SOCIAL DETERMINANTS OF HEALTH
ARE PARTICULARLY PROBABLY
AFFECTED AND RESPONSIVE AND
VULNERABLE TO CLIMATE CHANGE,
SIMILARLY, THOSE WHO HAVE
CO-MORBIDITIES OR HAVE LOWER
SOCIAL CAPITAL OR LOWER
SOCIOECONOMIC STATUS MAY BE
SENSITIVE AND VULNERABLE TO
THOSE ENVIRONMENTAL SHIFTS.
THIS IS AFFECTING EXPOSURE,
PROFILE OF A VARIETY OF THE RISK
FACTORS AND OUR DISEASE
PORTFOLIO, AS A RESULT OF THESE
POTENTIAL EXPOSURES TO MORE ALER
GENS AS AN EXPOSE TOWER THESE
CLAIMATE CHANGE AND
ADDITIONALLY, IN TERMS OF HOW WE
MIGHT BUILD RESILIENCE AND
CHANGE IT BACK TO CAPACITY AND
HOW IT MIGHT BE INCORPORATED IN
A WAY TO PROMOTE ENHANCEMENTS IN
HUMAN HEALTH, MITIGATE THE
DELETEEROUS HEALTH OF CLIMATE
CHANGE AND AS THEY RELATE TO
NHLBI PORTFOLIO.
NEXT SLIDE, PLEASE, TOWARD THAT
END, WE SEE AN OPPORTUNITY, TO
ASSESS THESE CLIMATE DRIVERS
LIKE WILDFIRES AND EXTREME
WEATHER EVENTS, MAY IMPACT AIR
QUALITY AND EXTREME HEAT AND HOW
THAT MIGHT TRANSLATE FROM THOSE
EXPOSURE PATHWAYS TO DIFFERENT
HEALTH OUTCOMES AND HOW THOSE
HEALTH OUTCOMES MAY VARY, BE
HETEROGEANIOUS WITH MAYBE
CERTAIN COMMUNITIES
DISPROPORTIONATELY AFFECTED BY
CLIMATE CHANGE.
NEXT SLIDE, PLEASE.
TOWARD THAT END, THERE IS
EMERGING DATA THAT RAISES THESE
CONCERNS THAT ALTHOUGH FOR
EXAMPLE, THE HEAT RAYS OF THE
SUN MAY BE RELATIVELY EVENLY
DISTRIBUTED ACROSS ALL THE
COMMUNITIES OF OUR COUNTRY,
THERE ARE STILL COMMUNITIES THAT
ARE DISPROPORTIONATELY AFFECTED
BY SOMETHING LIKE THE SURFACE
HEAT INTENSITY, FOR EXAMPLE,
THERE'S A STUDY DOWN THE COUNTY
LEVEL RESOLUTION THAT LOOKED AT
COMMUNITIES THAT WILL FEEL THE
BRUNT OF THE URBAN HEAT ISLANDS,
THAT NOTION THAT AGAIN AS A GUY
WHO GREW UP IN INNER CITY
PHILADELPHIA, I AM VERY FAMILIAR
WITH THE NOTION OF GETTING ROWS
AND ROWS OF HOUSES WITH BLACK
ROOFS AND ASPHALT ROADWAYS WITH
SMALL SIDEWALKS AND NO TREES, IT
CAN GET PRETTY HOT IN THE SUMMER
AND SO, IT'S NOT TOO SURPRISING
TO ME ANYWAY, THAT IN 83 OF 106
U.S. CITIES PEOPLE OF COLOR
EXPOSED TO AN AVERAGE SUMMER
SURFACE TEMPERATURE THAT'S
2-DEGREES CELSIUS HIGHER THAN
THE AREAS OUTSIDE THE CITY AND
THAT'S ONLY TRUE FOR A RACIAL
GAP IN TERMS OF VULNERABILITY IN
TERMS OF THESE EXTREMES BUT
SIMILAR TREND AND SEEN FOR LOWER
SOCIOECONOMIC STATUS AND SO, WE
CAN ANTICIPATE THAT LIKE MANY
OTHER STRESSORS AND
ENVIRONMENTAL FACTORS LIKE MANY
OTHER ELEMENTS OF THE BUILT
ENVIRONMENT, THERE MAY BE A
DIFFERENTIAL IMPACT IN CERTAIN
COMMUNITIES THAT ARE
PARTICULARLY VULNERABLE AND
THEREFORE THAT MAY TRANSLATE
INTO DIFFERENT EXPOSURES AND
HEALTH OUTCOMES.
NEXT SLIDE, PLEASE.
TOWARD THAT END, WE HAVE THAT
CHALLENGE RAISES AN OPPORTUNITY,
IN WHICH--IS THAT JUST MY SCREEN
THAT JUST GOT A POP-UP?
OKAY, SORRY.
THAT WE HAVE AN OPPORTUNITY TO
REDUCE THE HEALTH THREATS ACROSS
THE LIFE SPAN AND BUILD HEALTH
RESILIENCE, IN INDIVIDUALS,
COMMUNITIES AND OUR NATION AS
WELL AS PROVIDE LEADERSHIP
AROUND THE WORLD TO ADDRESS
THESE ADVERSE EFFECTS OF CLIMATE
CHANGE.
AND ON THE RIGHT THERE IS THE
STRATEGIC FRAMEWORK OF THE
TRANSNIH EFFORT LED BY NIEHS
INVOLVING HOW WE NEED TO
APPROACH CLIMATE CHANGE AND
HEALTH FOR THE NIH THAT
ADDRESSES HEALTH EFFECTS
RESEARCH, HEALTH EQUITY,
TRAINING, CAPACITY BUILDING AND
INTERVENTION SCIENCE THAT CAN
ADDRESS THIS EXSTENTIAL THREAT.
NEXT SLIDE, PLEASE.
TOWARD THAT END, I THINK THERE
ARE A NUMBER OF ELEMENTS THAT
ARE PARTICULARLY RELEVANT TO THE
NHLBI COMMUNITY, NEXT SLIDE,
PLEASE THAT WE THINK ALIGN WITH
THIS TRANSNIH EFFORT IN CLIMATE
CHANGE AND HEALTH.
PARTICULARLY JUST GIVE A
HIGHLIGHT TO ASTHMA AS REALLY AN
EXEMPLAR AS WITH OUR PORTFOLIO
IN WHICH THERE'S LIKELY TO BE
THIS INTERSECTION BETWEEN THE
ENVIRONMENTAL I AM NOT PACT OF
CLIMATE CHANGE--OF AFFECTING
CHILDREN WITHIN COMMUNITIES OF
COLOR.
SO WE'RE ALREADY FAMILIAR AS
SHOWN ON THE LEFT WITH THE
RACIAL ETHNIC DISPARITIES IN
ASTHMA THAT WE KNOW EXIST AND SO
AS WE TAKE THIS CLIMATE CHANGE
LENS AND SEE THAT THE CLIMATE
DRIVERS OF WILDFIRES WILL
INFLUENCE EXPOSURE PATHWAYS
RELATED TO POOR AIR QUALITY AND
INCREASED ALER GENS IN A WAY
THAT COULD CLEARLY EXACERBATE
HEALTH OUTCOMES BOTH ACUTE AND
CHRONIC IN RESPIRATORY
ILLNESSES, ACROSS THE LIFE SPAN,
PARTICULARLY HITTING AGAIN THE
MOST VULNERABLE CHILDREN AND THE
ELDERLY.
NEXT SLIDE, PLEASE.
WE ALREADY ARE WELL AWARE OF
EVIDENCE WHERE THERE ARE PLACES
WHERE THERE IS LONG-TERM HIGHER
EXPOSURES TO AIR POLLUTION AND
IMPLICATIONS OF LUNG HEALTH AND
YOU CAN SEE THE EXPOSURE BY
RACE-ETHNICITY AND ON THE RIGHT
YOU CAN SEE HOW THIS IS ACTUALLY
PLAYING OUT AT THE COMMUNITY
LEVEL IN WHICH THERE ARE
REDUCTIONS IN LUNG FUNCTION,
LUNG CAPACITY, AS CHILDREN GROW
AND DEVELOP THAT'S REFLECTED BY
WHERE THEY LIVE, WORK AND PLAY
AND THIS IS CLEARLY ALREADY BEEN
SEEN WITH REGARD TO AIR
POLLUTION AND THE COMMUNITIES IN
WHICH YOU LIVE, NEXT SLIDE,
PLEASE.
THIS CLEARLY HAS LONG-TERM
IMPLICATIONS BECAUSE AGAIN, IT'S
AFFECTING THE STRUCTURE AND
FUNCTION OF THE DEVELOPING LUNG
WITH LONG STANDING, LONG LASTING
CONSEQUENCES THEREOF.
INDEED IN CONTEXT IN WHICH,
INTERVENTIONS ARE MADE TO REDUCE
AIR POLLUTION, THERE IS THE
ADDITION OR CAPACITY TO
EMELIORATE THESE AND THIS MAY
PAN OUT AS WE THINK ABOUT THE
LONG ARC OF CLIMATE CHANGE AND
ITS IMPLICATION FOR AIR
POLLUTION.
NEXT SLIDE, PLEASE.
INDEED, IT'S CLEAR THAT THERE IS
NOW THIS NEW AIR QUALITY
CHALLENGE RELATED TO THIS
INCREASED EXPOSURES TO WILDFIRE
OR SMOKE AND POOR HEALTH
OUTCOMES IN WHICH YOU CAN SEE ON
THE LEFT, AND INCREASING
IMPLICATIONS OF WILDFIRE SMOKE
EXPOSURE THAT ARE NOT JUST
LIMITED TO CALIFORNIA BUT INDEED
HAVE IMPLICATIONS ACROSS OUR
COUNTRY AND 1 IN FACT IN WHICH
THE SUPER IMPOSITION OF CLIMATE
CHANGE MAY FURTHER EXACERBATE
THESE CHALLENGES, AGAIN ACROSS
OUR NATION AND PARTICULARLY
CONCENTRATED IN THOSE
VULNERABILITY COMMUNITIES.
NEXT SLIDE, PLEASE.
TOWARD THAT END, WE GAVE YOU
THAT EXAMPLE OF ASTHMA AND
WILDFIRES AND AIR POLLUTION,
THIS MAY ALSO PAN OUT IN
EXACERBATION OF HEALTH
INIQUITIES WITH A CHALLENGE OF
URBAN HEAT ISLANDS AND HELT
DISPARITIES AS MANY OF YOU ARE
AWARE, MANY OF THE UNDERLYING
CAUSES OF HEAT DEATHS IN THE
UNITED STATES COME BACK TO THE
NHLBI PORTFOLIO, CLEARLY
EXACERBATIONS OF THE ASCHEMIC
HEART DISEASE, HEART FAILURE,
RESPIRATORY ILLNESSES AND ARE
AMONGST THE MAJOR FACTORS,
THERMOREGULATION, PARTICULARLY
CAUSING CARDIOVASCULAR
CHALLENGES AND HEAT STROKE.
AND SO, CLEARLY THE EXTREMES OF
HEAT AND WEATHER HAVE
IMPLICATIONS FOR OUR COMMUNITY
AND OUR PORTFOLIO.
YOU CAN SEE IN THE MIDDLE THERE,
THE HEAT STRESS DEATHS, A DEEPER
DIVE MORE GRANULAR IN NEW YORK
CITY AND AGAIN THE
OVERREPRESENTATION OF
COMMUNITIES OF COLOR AS BEING
MOST ADVERSELY AFFECTED IN THIS
CONTEXT AND NOTE WORTHY THAT IT
IS OFTEN THE BUILT ENVIRONMENT
CONTEXT AND SOCIAL DETERMINANTS
OF HEALTH THAT ARE DRIVING THESE
PARTICULAR RACE ETHNIC
VULNERABILITIES SUCH THAT INDEED
BUILDING HEIGHT, HISTORIC RED
LINE THAT HAS SHAPED THE
STRUCTURES OF CERTAIN
NEIGHBORHOODS CONCENTRATING ON
THE ADVERSE IMPACT OF THESE
WEATHER EXTREMES.
NEXT SLIDE, PLEASE.
EVEN IN OUR WASHINGTON D. C.
AREA, IT'S NOTE WORTHY THAT IF
YOU LOOK BACK ON THE LEFT AT THE
FEDERAL HOUSING ADMINISTRATION
MARKET ANALYSIS THAT REALLY THE
UNDERPINNINGS OF THAT HISTORICAL
RED LINES WHICH YOU CAN SEE THE
STRETCH OF WHAT THEY CALL TYPE
A, THE HIGHEST GRADE OF PROPERTY
AND INVESTMENT TENDED TO BE
TUCKED INTO THE NORTHWESTERN
CORNER OF WASHINGTON D. C., AND
AS YOU CAN SEE TYPE H, QUOTATION
REPRESENTS NEGRO DEVELOPMENT AND
LOWEST GRADE THAT H IS IN THE
SOUTHEAST REGION OF WASHINGTON
D. C. AND THIS IS BACK IN THE
1930S.
AS YOU CAN NOTE IN THE MIDDLE
PANEL MULTIPLE GENERATIONS
LATER, YOU CAN SEE THE RACIAL
DEMOGRAPHIC PROFILE OF THE
NORTHWEST PREDOMINANTLY MORE
WHITE IN THE SOUTHEAST
CONCENTRATION OF AFRICAN
AMERICAN NEIGHBORHOODS AND
COMMUNITIES AND NOTE WORTHY
RELATED TO THAT IF YOU LOOK AT
THE HEAT ISLAND EFFECTS MOSTLY,
YOU WOULD AGAIN SEE THAT
CONCENTRATION OF THOSE EXTREMES
IN THE SOUTHEAST SECTOR OF THE
CITY.
NEXT SLIDE, PLEASE.
THOSE ARE ALL, I MIGHT
PARENTHETICALLY NOTE, IF WE DO A
MAP OF WHERE HEART DISEASE IS
THE GREATEST WHERE LIFE
EXPECTANCY IS THE SHORTEST, AND
WHERE WE SEE DISPARITIES, THAT
SOUTHEAST CORNER UNFORTUNATELY
S&P OFTEN THE 1 THAT'S
OVERREPRESENTED FOR THE PORTION
OF MORBIDITY AND MORTALITY.
TOWARD THAT END, THIS IS AN
OPPORTUNITY TO NOT ONLY RESEARCH
AND STUDY THE CHALLENGES, BUT
HOPEFULLY START TO DEVELOP
INTERVENTIONS THAT PROMOTE
RESILIENCE AND MITIGATE THE
IMPACT AND INDEED THERE HAVE
BEEN SOME PROJECTS AND
INTERVENTIONS THAT HAVE BEEN
TRIED INCLUDING EVEN SOMETHING
AS STRAIGHT FORWARD AS PAINTING
A BLACK ROOF WHITE AND
DEMONSTRATE THAGOREAN AGAIN IN
THOSE THOSE RESIDENCES THAT THE
EXTREMES OF HEAT MIGHT BE
MITIGATED.
THIS ACTUALLY COULD BE LIFE
SAVING FOR ELDERLY PEOPLE IN
SOME OF THESE COMMUNITIES AND SO
REALLY IT'S MEASURING THESE DOWN
STREAM OUTCOMES MAY BE AN
OPPORTUNITY TO HAVE AN IMPACT ON
ADDRESSING SOME OF THE IMPACTS
OF CLIMATE CHANGE THAT IMPACT
THE MOST DISPROPORTIONATE
COMMUNITIES.
SO THIS IS AN OPPORTUNITY WE
THINK THAT LEVERAGE COMMUNITY
ENGAGED RESEARCH PLATFORMS TO
ADDRESS THE IMPACT OF CLIMATE
CHANGE ON HEALTH OR PROMOTE
HEALTH EQUITY AS WE LOOK AT
THESE INTERSECTIONS AND THE
IMPACT OF THAT EXSTENTIAL
PLANETARY HEALTH EFFECTS AND AN
OPPORTUNITY TO PERHAPS LEVERAGE
SOME OF THE LESSONS LEARNED FROM
PROGRAMS SUCH AS DECIPHER, MORE
RECENTLY IN THE PANDEMIC, THE
SEAL'S PROGRAM, THE ALLIANCE
AGAINST COVID-19 DISPARITIES IN
WHICH WE ACTUALLY TAKE ON THE
SOCIAL DETERMINANTS OF HEALTH.
THE ENVIRONMENT, THE BUILT
ENVIRONMENT AND USE INTEGRATED
ASSESSMENTS TO IDENTIFY LOCAL
RESEARCH NEEDS TO LEVERAGE
COMMUNITY PROGRAMS, TO REACH THE
MOST VULNERABLE PROMOTE INCLUDES
PARTICIPATION IN THESE
ADAPTATIONS THAT AVENGHT
COMMUNITIES AND PROMOTE
ADHERENCE AND TIPS AND RESOURCES
ABOUT HOW TO MITIGATE THE IMPACT
OF CLIMATE CHANGE IN THESE
COMMUNITIES.
NEXT SLIDE, PLOAZ.
AND FINALLY, I THINK THIS WILL
BE AN OPPORTUNITY TO FURTHER
EXPAND OUR DATA RESOURCES
LEVERAGING PARTNERSHIPS TO
BETTER INFORM PUBLIC HEALTH, NOT
ONLY THE SURVEILLANCE AND
IDENTIFICATION OF THOSE HOT
SPOTS LITERALLY AND FIGURATIVELY
THAT ARE IMPACTED BY CLIMATE
CHANGE IN THE FACTORS AND IMPACT
BUT ALSO IN THE CLIMATE STUDY
AND THEN BEING ABLE TO ADDRESS
THE TRAJECTORY OF HEALTH
OUTCOMES THAT MAY BE PART OF
THAT EXPOSURE AND THIS IS AN
OPPORTUNITY TO INTEGRATE A
VARIETY OF DATA SOURCES, DATA
PIPES, WHETHER IT'S SATELLITE
DATA FROM NASA DIAGONALS US
ABOUT CLIMATOLOGY OR THE SENSORS
OR THE EPA SENSORS THAT ARE
TELLING US ABOUT PARTICULAR
MATTER AND VARIOUS EXPOSURES
FROM THE ENVIRONMENT OR GIS DATA
THAT'S TELLING US SOMETHING
ABOUT THE VULNERABILITY OF
PARTICULAR COMMUNITIES.
THE CAPACITY OF MOBILE AND
PERSONAL SENSOR DATA TO PICK UP
THINGS LITERALLY AT THAT LOCAL
LEVEL, THAT PERSONAL LEVEL OF
EXPOSURE, AND RESPONSE TO THE
ENVIRONMENT THAT COULD BE
LEVERAGED IN THIS CONTEXT AS
WELL AS OTHER SYSTEMS OF
INFORMATION AT DAILY BASIS THEA
HEALTH AND RESOURCE AND SCALE
AND DEPTH AND GRANULARITY SO
THIS IS A CHALLENGE OF DATA
IMMIGRATION AND HARMONIZATION
AND SHARINGING IN A WAY THAT NOT
ONLY TRACKS THE PROBLEM BUT
HOPEFULLY PROVIDES A PATHWAY TO
ASSESS OUR INTERVENTIONS TO
MITIGATE.
NEXT SLIDE, PLEASE SO WE SEE
THIS AS A FURTHER EXTENSION OF
THE NHLBI RESOURCE BIODATA
CATALYST THAT SHOULD BE
INTEROPERABILITY AND CONNECT
WITH THESE DIFFERENT ELEMENTS
AND DIFFERENT DATA TYPES, DATA
SOURCES WHETHER THAT'S
ENVIRONMENTAL ELEMENTS, OTHER
COHORTS, AND ALL THESE DIFFERENT
DATA TYPES IN AN INTEGRATIVE WAY
WITH CROSS DISCIPLINARY TEAMS
NECESSARY TO ANALYZE THAT DATA
AND TO TRANSLATE THE CLIMATE
DRIVERS, THE EXPOSURE PATHWAYS
AND HEALTH EFFECTS IN A
WHOLISTIC AND INTEGRATED FASHION
THAT WILL BE A CHALLENGE BUT
THAT'S THE OPPORTUNITY, I THINK
THAT THIS NEW INITIATIVE HOLDS
FOR US ACROSS NIH DRAWING UPON
THAT EXPERTISE AT NIH, AS WELL
AS OTHER FIELDS SUCH AS THE
CLIMBATTOLOGY AND ENVIRONMENTAL
EXPERTS, NEXT SLIDE, PLEASE.
SO THIS WAS IN MANY WAYS
HOPEFULLY A SET UP TO OUR GUEST
SPEAKER DR. RICK WOYCHIK, BEING
THE LEAD IC OF THIS TRANSNIH
EFFORT IN WHICH WE HOPE TO
ENGAGE DIVERSE COMMUNITIES,
FOSTER DIVERSE PARTNERSHIPS,
EXPAND CLIMATE AND HEALTH
INDICATORS IN OUR COHORT
STUDIES, LEVERAGE AND EXPAND
EXISTING RESOURCES, SUCH AS
THOSE FOR OUR BIG DATA AND
DEVELOP MULTIDISCIPLINARY
WORKFORCE TO EXPLORE THIS DATA
AND DEVELOP INNOVATIVE SOLUTIONS
AND ADAPTIVE STRATEGIES.
NEXT SLIDE, PLEASE.
AND WITH THAT, I SAY THANK YOU
FOR YOUR ATTENTION AND
APPRECIATE THE STRATEGIC
GUIDANCE OF OUR ADVISORY COUNCIL
AS WE LOOK FORWARD TO THE
INITIATIVES TODAY AS WELL AS
THESE NEW OPPORTUNITIES TO ON
THE HORIZON, SUCH AS ADDRESSING
CLIMATE CHANGE AND HEALTH.
THANK YOU.
>> THANK YOU DR. GIBBONS.
DOES ANYBODY HAVE ANY QUESTIONS
FOR DR. GIBBONS OR SOME COMMENTS
THAT THEY WOULD PERHAPS LIKE TO
MAKE?
>>WE HAVE A COMMENT FROM JEN,
VERY EXCITING THANK YOU.
SO, IT'S ALWAYS HARD TO BE THE
FIRST SPEAKER AFTER LUNCH.
WELL, I BELIEVE THAT OUR NEXT
SPEAKER IS HERE.
SO I'M GOING TO GO AHEAD AND
INTRODUCE HIM, DR. RICK WOYCHIK
IS THE DIRECTOR OF NATIONAL
INSTITUTE OF ENVIRONMENTAL
HEALTH SCIENCES AND THEN THE
NATIONAL TOXICOLOGY PROGRAM.
HE'S A MOLECULAR GENETICIST WITH
A Ph.D. IN MOLECULAR BIOLOGY
FROM CASE WESTERN RESERVE AND A
POST DOCTORAL TRAINING WITH DR.
PHIL EPIGENETIC LITTER AT
HARVARD MEDICAL SCHOOL.
HE SPENT ALMOST 10 YEARS
AT----1997 HE ASSUMED THE ROLE
OF VICE CHAIRMAN FOR PEDIATRICS
AT CASE WESTERN UNIVERSITY.
IN 1998 HE MOVED TO
SAN FRANCISCO OR THE BAY AREA,
ANYWAY, FIRST AS THE HEAD OF THE
PARK DAVIS LABORATORY FOR
MOLECULAR GENETICS AND THEN AS
CHIEF SCIENTIFIC OFFICER AT
LINKS THERAPEUTICS.
HE THEN RETURNED TO ACADEMICS AS
THE PRESIDENT AND CEO OF THE
JACKSON LABORATORY IN AUGUST OF
2002 AND SERVED IN THAT ROLE
UNTIL JANUARY 2011, WHERE HE
THEN CAME TO JOIN NIEHS AS THE
DEPUTY DIRECTOR.
SO PLEASE JOIN ME IN WELCOMING
DR. WOYCHIK, HE'S GOING TO BE
SPEAKING TO US ABOUT CLIMATE
CHANGE AND HEALTH EQUITY, A
STRATEGIC FRAMEWORK TO ENHANCE
SOLUTIONS ACROSS NIH.
WELCOME DR. WOYCHIK?
>> THANK YOU LAUREN.
>> THANK YOU.
>> YES, YES YOU ARE.
>> TERRIFIC.
WELL, THANK YOU FOR THE GREAT
INTRODUCTION AND I WILL--WITH
THE INTRODUCTION FOR THE WHOLE
ISSUE OF CLIMATE CHANGE AND
HEALTH EQUITY, I WILL CONTINUE
ON THIS THEME.
ALTHOUGH THEA THE ONSET I WANT
TO ACKNOWLEDGE RIGHT UP FRONT
THAT I'M GIVING THIS
PRESENTATION ON BEHALF OF 6
OTHER IC DIRECTORS INCLUDING
GARY, DIANNA BIANCHI, JOSH
GORDON, DR. PEREZ-STABLE, AND
DR. ZENC, SO WE HAVE ALL
SELF-ASSEMBLED INTO A GROUP TO
PROVIDE LEADERSHIP THAT REALLY
AIMS TO ADDRESS THE CHALLENGES,
MANY OF THE CHALLENGES THAT GARY
JUST MENTIONED THAT ARE
ASSOCIATED WITH CLIMATE CHANGE
IN HEALTH.
SO LET ME GO ON TO THE NEXT
SLIDE ISSUES PLEASE.
SO PRESIDENT BIDEN HAS ISSUED 2
IMEKATIVE ORDERS TO CHANGE
LIMATE HEALTH AND HUMAN HEALTH.
THE FIRST OF THESE WAS 13990
WHICH INVOLVES PROTECTING PUBLIC
HEALTH AND THE ENVIRONMENT AND
RESTORING SCIENCE TO TACKLE THE
CLIMATE CRISIS.
THE SECOND EXECUTIVE ORDER WAS
14008 WHICH INVOLVES TACKLING
THE CLIMATE CRISIS AT HOME AND
ABROAD.
IT TAKES A GOVERNMENT WIDE
APPROACH TO THE ISSUE OF THE
CLIMATE CRISIS AND IT'S BASED ON
AN ENVIRONMENTAL JUSTICE
FRAMEWORK, SO THIS EXECUTIVE
ORDER ALSO CREATES A WHITE HOUSE
ENVIRONMENTAL JUSTICE
INTERAGENCY COUNCIL AND
ESTABLISHES THE OFFICE OF
CLIMATE CHANGE AND HEALTH EQUITY
AND THAT'S LOCATED WITHIN HHS.
IT ALSO ESTABLISHES THE JUSTICE
40 INIT QUAATIVE THAT MANDATES
THAT FEDERAL INVESTMENTS TO BE
TARGETED TOWARD--FEDERAL
INVESTMENTS SHOULD BE TARGETED
TOWARD THE GOAL THAT 40% OF OVER
ALL BENEFITS OF INVESTING
CLIMATE CHAIMPLE SHOULD FLOW TO
THE DISADVABTAGED COMMUNITIES
THAT GARY WAS TALKING ABOUT IN
HIS PRESENTATION.
SO TO SUPPORT THE EXECUTIVE
ORDERS, THE PRESIDENT, THE HOUSE
AND THE SENATE BUDGET VS ALL
INCLUDED LANGUAGE TO ALLOCATE
$100 MILLION.
WHICH WOULD BE DEDICATED TO
SUPPORT RESEARCH AND CLIMATE
CHANGE AND HEALTH EQUITY.
SO WHILE THE FUNDING WILL BE PUT
INTO THE NIEHS BUDGET, IT'S
CLEAR THIS IS MUCH BIGGER THAN
WHAT ANY 1 IC CAN ACCOMPLISH ON
THEIR OWN, SO THEREFORE WE'RE
TAKING AN APPROACH WHERE THE
HUNDRED MILLION DOLLARS WILL BE
USED TO CATALYZE AN NIH WIDE
RESPONSE TO ADDRESS THE NEEDS
AROUND CLIMATE CHANGE HEALTH AND
HEALTH EQUITY.
SO LET ME HAVE THE NEXT SLIDE
PLEASE.
SO THIS SLIDE, AGAIN BUILDING ON
IN GARY'S PRESENTATION, THIS
SLIDE REALLY SAYS IT ALL IN THE
TOPIC OF CLIMATE CHANGE.
SO WE'RE CLEARLY AT A POINT
WHERE ACCORDING TO THE SECRETARY
GENERAL OF THE UNITED NATIONS WE
ARE EXPERIENCING A CODE RED FOR
HUMANITY.
CLIMATE CHANGE EXACERBATES
CHRONIC AND CONTAGIOUS DISEASES,
IT WORSENS FOOD AND WATER
SHORTAGES, IT INCREASES RISKS OF
PANDEMICS AND IT AGGRAVATES MASS
DISPLACEMENT.
SO WE ARE SEEING AN INCREASE
SEVERITY AND FREQUENCY OF
WEATHER RELATED DISASTERS
LASTING OVER A BILLION DOLLARS.
SO IN 2020 ALONE WE SAW 22 SUCH
EVENTS, COSTING A TOTAL OF 450
BILLION DOLLARS AND WORE AT THE
POINT WHERE WE NEED TO BETTER
UNDERSTAND THE LONG LASTING
HEALTH IMPACTS OF THESE SEVERE
WEATHER EVENTS.
NEXT SLIDE, PLEASE.
AND THESE SEVERE FLOODING, HEAT
WAVES AND EXTREME WEATHER EVENTS
ARE HAPPENING ACROSS THE GLOBE.
WE SAW LAST YEAR THAT CLIMATE
CHANGE DOES NOT GO AWAY AS WE
EXPERIENCED IN OTHER
AREAS--WEATHER EVENTS ARE FELT
MOSTLY BY UNDERRESOURCED AND
MARGINALIZED COMMUNITIES WHICH
IS A VERY IMPORTANT POINT I WANT
TO REINFORCE AND THAT GARY MADE
AS WELL.
NEXT SLIDE.
SO THIS SLIDE ILLUSTRATES THE
ENORMOUS COMPLEXITY ASSOCIATED
WITH HOW CLIMATE IMPACTS HEALTH
OUTCOMES AND SO THE CLIMATE
DRIVERS AT THE TOP AFFECT HEALTH
OUTCOMES DIRECTLY THROUGH
WEATHER EVENTS SUCH AS CREAM
HEAT, WILDFIRES, DROUGHTS, STORM
SURGES OR FLOOD OR HEALTH IMPACT
INCORRECTLY THROUGH EXPOSURE
PATHWAYS SUCH AS AIR AND WATER
QUALITY, FOOD QUALITY AND
INFECTIOUS DISEASES AND MASSIVE
DISPLACEMENT, HUMAN POPULATION
DISPLACEMENT EVENTS.
THESE PATHWAYS THEMSELVES ARE
INFLUENCE BIDE ENVIRONMENTAL
CONTEXT, RELATED TO LAND,
GEOGRAPHY, ECOSYSTEM,
INFRASTRUCTURE AND AGRICULTURE
THIS CREATES VULNERABILITY
BETWEEN LIFE STAGE, GENDER RACE,
AGE AND CARE.
SO ANY HEALTH WILL INVOLVE
INTERDISCIPLINARY FOR HEAT
RELATED ILLNESS, CARDIO PULL
MONITORARY ILLNESS,
PSYCHO-SOCIAL STRESS, FOOD, AND
VECTOR BORNE DISEASE.
COMPLICATED ISSUE.
NEXT SLIDE.
SO NIEHS HAS BEEN INVOAOF THING
IN CLIMATE CHANGE AND HEALTH
RESEARCH FOR OVER A DECADE, WE
FUNDED GRANTS AREYALATED TO
CLIMATE CHANGE AND THEY'VE BEEN
FOCUSED ON THE TYPES OF
ENVIRONMENTAL EXPOSURES THAT
RESULT FROM DISASTERS LIKE
WILDFIRES, FLOODS, HURRICANES
AND VARIOUS OTHER TYPES OF
EXTREME WEATHER EVENTS.
AS WE'VE ALSO SUPPORTED RESEARCH
ON THE RESPIRATORY,
CARDIOVASCULAR AND COGNITIVE
HEALTH RELATED EFFECTS CAUSED BY
CLIMATE CHANGE.
AS I JUST MENTIONED THE PROBLEM
IS BIGGER THAN JUST WHAT 1 IC AT
THE NIH CAN DO.
CLIMATE CHANGE GREATLY ELEVATES
THREATS TO HUMANS ACROSS A WIDE
RANGE OF ILLNESSES, AND THESE
RANGE FROM ASTHMA, AND
RESPIRATORY DISEASES, CANCER,
CARDIO VASCULARY DISEASES AND
STROKE, CHILDREN'S HEALTH,
HEALTH DISPARITIES, ALL THE WAY
TO MENTAL HEALTH AND
NEUROLOGICAL DISORDERS AND
EXTREME WEATHER RELATED
MORBIDITY AND MORTALITY AND IT'S
HAPPENING ON A GLOBAL SCALE.
SO THEREFORE I'VE BEEN WORKING
TOGETHER WITH GARY AND 6 OTHER
IC DIRECTORS I MENTIONED EARLIER
AND TOGETHER WE HAVE FORMED WHAT
WE ARE CALLING THE EXECUTIVE
COMMITTEE ON CLIMATE CHANGE AND
HEALTH.
SO WHILE I'M SHARING THE
EXECUTIVE COMMITTEE, I EXPECT TO
BE WORKING TOGETHER WITH GARY
AND OTHER IC DIRECTORS FOR THE
LEADERSHIP AND HEALTH INITIATIVE
ACROSS THE NIRE H.
THE EXECUTIVE COMMITTEE HAS
REENERGIZED A LONG STANDING
WORKING GROUP WITH 100 MEMBERS
ACROSS THE INSTITUTES AND
CENTERS AT THE NIH.
SO THE WORKING GROUP IS
CURLENIENT CO CHAIRED BY AWBRY
MILLER AND JOSH ROSENTHAL AT
FOGARTY INTERNATIONAL WILL.
THERE'S ALSO A STEERING
COMMITTEE GROUP WITH, POINTEES
FROM THE ICs REPRESENTED ON
THE EXECUTIVE COMMITTEE.
SO THE STEERING COMMITTEE IS,
WOOING WITH DRS. MILLER AND
RESOURCESSEN
ROSENTHALL, TO WORK ON THOSE AND
ACHIEVE.
AND OUR OWN GWIN COLEMAN AND
PROVIDING THE MUCH NEEDED
CENTRAL ACCORD NATION TO KEEP
ALL MOVING PARTS WORKING IN
SYNCHRONY, GWEN IS JOINING US
TODAY AND SHE IS ON THE PANEL
TODAY AND WILL BE AVAILABLE TO
HELP ADDRESS AND QUESTIONS OR
LISTEN TO ANY COMMENTS YOU MAY
HAVE.
NEXT SLIDE, PLEASE.
SO 1 OF THE FIRST THINGS THE
WORKING GROUP DID LAST SUMMER
WAS TO CONDUCT A PORTFOLIO
ANALYSIS OF OUR FUNDING PROFILE
FOR THE WORK RELATED TO CLIMATE
CHANGE AND HEALTH ACROSS THE
NIH.
SO THE FIRST PASS ANALYSIS
REVEALED THAT WE'RE ABOUT 350
GRANTS FUNDED FROM 2011 TO 2020.
AND WHILE IT WAS CLEAR THAT THE
VAST MAJORITY OF THE AWARDS WERE
MADE BY NIEHS, THERE WERE ALSO
21 OTHER ICTHAT IS HELPED WITH
RESEARCH AND CAPACITY BUILDING
PRONG ELECTRIC LIGHTINGS.
NIAID WAS NEXT HIGHEST IN THE
NUMBER OF GRANDS WITH 45 AND
FOGARTY WITH 32 AND NICHD AT 29.
I SEE ALSO THAT HL IT WAS IN THE
GAME WITH 10, BUT I WONDER IF
WE'RE UNDERCOUNTING THIS BASED
ON THE PRESENTATION THAT GARI
JUST GAVE.
SO WE'LL HAVE TO TAKE A LOOK AT
THAT BUT NEVERTHELESS, IT'S GOOD
TO SEE THAT HEART LUNG BLOOD IS
VERY INTERESTED IN THIS WHOLE
TOPIC AREA.
NEXT SLIDE.
SO USING THE RCDC, THE, WARDS
OVER THE PAST 10 YEARS WERE
ORGANIZED BY EXPOSURES,
OUTCOMES, METHODS AND--ALL THE
WAY TO FIRE AND WILDFIRE AND ON
THE RIGHT WE FUNDED AWARDS WITH
A VARIETY OF HEALTH OUTCOMES
RANGING FROM RESPIRATORY TO
MATERNAL HEALTH TO HEAT STRESS
AND DENGUE, SO THESE WERE JUST
THE TOP OUTCOME CONCEPTS IN THE
AWARDS FUNDED OVER THE PAST 10
YEARS.
NEXT SLIDE, PLEASE.
SO AS WE STARTED DEVELOPING OUR
PLANS, THE STEERING COMMITTEE
ISSUED A REQUEST FOR INFORMATION
LAST AUGUST, AND THE PURPOSE WAS
TO GATHER BROAD INPUT ON THE
APPROACHES THAT THE NIH COULD
TAKE TO ENHANCE RESEARCH ON THE
HEALTH IMPLICATIONS OF CLIMATE
CHANGE IN THE UNITED STATES AND
AROUND THE WORLD.
SO RESPONSES WERE SUBMITTED TO
THE NIH BY E-MAIL AND THEY WERE
DUE BY MIDSEPTEMBER ASK AND WE
WERE REALLY IMPRESSED.
A TOTAL OF 184 DIFFERENT
RESPONSES WERE RECEIVED, WITH
SUBSTANDIVE INPUT, RANGING FROM
ORGANIZATIONS THAT WERE ACADEMIC
INSTITUTIONS, PROFESSIONAL
SOCIETIES, GOVERNMENT AGENCIES,
NGOs, AND MANY OTHERS.
THE SUBMISSIONS WERE CODED ALONG
THE LINES OF 6 CLIMATE CHANGE
AND HEALTH PRIORITY AREAS.
ONE BEING INNOVATIVE RESEARCH,
ANOTHER BEING TRANSLATION AND
DISSEMINATION, SCIENTIFIC
INFRASTRUCTURE WAS THE THIRD,
DIVERSE WORKFORCE, PARTNERSHIPS
TO ADDRESS ENVIRONMENTAL JUSTICE
AND RESILIENCE, AS WELL AS RAPID
RESEARCH RESPONSE CAPACITY.
SO MOST OF THE RESPONSES WERE IN
THE INNOVATIVE RESEARCH CATEGORY
AND THE RESPONSES WERE ALSO
IDENTIFIED WITH SUBTHEMES SUCH
AS MULTIDISCIPLINARY,
TRANSDISCIPLINARY PLINARY
RESEARCH, TRAINING, DIVERSITY
AND IONIZATION CLIEWGZ,
IMPLEMENTATION SCIENCE, COHORT
STUDIES AND BIG DATA.
NEXT SLIDE, PLEASE.
SO WHAT WOULD BE IMPORTANT IN
ANY PLAN TO EXECUTE ON CLIMATE
CHANGE AND HEALTH WILL BE THE
RECOGNITION THAT CLIMATE CHANGE
DOESN'T AFFECT EVERYONE EQUALLY,
AGAIN THIS IS BUILDING ON GARY'S
PRESENTATION WHERE IT CLEARLY
DOESN'T AFFECT EVERYONE EQUALLY.
WE WILL NEED TO RECOGNIZE THAT
USHED RESOURCED AND MARGINALIZED
POPPULESS LIKE SOME COMMUNITIES
OF COLOR, HAVE YOU POPULATIONS
WITH LOW INCOME AND LOW
EDUCATIONAL ASTAINMENT AS WELL
AS IMMIGRANT GROUPS INCLUDING
THOSE WITH LIMITED ENGLISH
PROFICIENCY, MANY INDIGENOUS
POPULATIONS, EXPOSED FARM AND
CONSTRUCTION WORKERS, AND
PERSONS WITH DISABILITY.
THESE ARE ALL POPULATIONS
ESPECIALLY IMPACTED BY CLIMATE
CHANGE.
AS GARY MENTIONED WE ALSO NEED
TO RECOGNIZE THAT THE FETUS,
INFANTS, YOUNG CHILDREN,
PREGNANT WOMEN AND THOSE IN
VULNERABLE LIFE STAGES OR THOSE
WITH CHRONIC MEDICAL CONDITIONS,
THEY ARE ALSO ESPECIALLY
IMPAICTED BY CLIMATE CHANGE AND
WE HAVE TO RECOGNIZE THAT
POPULATIONS IN LOW AND MIDDLE
INCOME COUNTRIES ARE AT
INCREASED RISK FOR THE IMPACT OF
CLIMB AT CHANGE DUE TO THE
HIGHER RATES OF EXISTING
DISEASES, MALNUTRITION AND
EXTREME POVERTY.
NEXT SLIDE, PLEASE.
AS A FITTER FIRST STEP IN
GETTING OUR HEADS AROUND CLIMATE
CHANGE AND HEALTH RESEARCH,
STAFF ACROSS THE NIH ON THE
WORKING GROUP GENERATED A LIST
OF RESEARCH PROJECTS THAT THEY
ENVISION WILL BE INCLUDED IN AN
NIH WIDE FRAMEWORK FOR CLIMATE
CHANGE AND HEALTH RESEARCH.
SO THERE'S A WHOLE LIST OF
THINGS HERE, AND THE LIST
INCLUDES DEVELOPING PREDICTING
MODELS OF EXTREME WEATHER
EVENTS.
DEVELOPING A PREDICTIVE MODELS
BASED ON ACCESS TO HELT CARE
SERVICES, TRAINING TO RESPONSES
IN AFRICA TO INFECTIOUS AND
EMERGING DISEASES, ANOTHER COULD
BE DETERMINING RISKS OF RISKS IN
COMMUNITIES.
ANOTHER COULD BE USING
IMPLEMENTATION SCIENCE TO INSURE
HEALTH EQUITY AND FLOOD
INTERVENTIONS.
ACCOUNTED BE STUDIES USING
COMPUTATIONAL MODELING OF
CLIMATE AND RESPIRATORY DYNAMICS
ACROSS THE UNITED STATES,
ANOTHER COULD BE DEVELOPING THE
MEASURES OF LONGITUDINAL CLIMATE
MEDIATED CLINICAL CHANGE IN
MINORITY POPULATIONS.
OTHERS COULD INVOLVE STUDYING
THE INFLUENCE EVER CLIMATE
CHANGE ON DEPRESSION OR AN
ADVANCING WAYS TO REDUCE LIMATE
SUICIDE IN INDIGENOUS GROUPS.
OF COURSE CONDUCTING BASIC AND
NECKANISTIC STUDIES TO BETTER
UNDERSTAND HOW HEALTH EXPOSURES
IMPACT CELLULAR SYSTEMS SUCH AS
MITOCHONDRIAL FUNCTION
OROXIDATIVE STRESS, SO THERE ARE
LOTS OF DIFFERENT IDEAS THAT 1
CAN PULL FROM.
AND THIS WAS REALLY JUST THE
START TO BEGIN TO THINK ABOUT
THE BROAD ARRAY OF POSSIBLE
APPROACHES FOR CONDUCTING
CLIMATE CHANGE AND HEALTH
RESEARCH.
NEXT SLIDE, PLEASE.
SO THE NIH-WIDE INIT
KACCT--INITIATIVE HAS SET
AMBITIOUS GOALS TO ULTIMATELY
REDUCE HEALTH THREATS OF
CLIMATE.
SO THE FIRST IS TO MITIGATE
RISKS AND OPTIMIZE BENEFITS, AND
THE SECOND IS TO RESEARCH AND
INFRASTRUCTURE AND WORKFORCE,
ACROSS THE BIOMEDICAL
DISCIPLINES.
THE THIRD IS LEVERAGE
PARTNERSHIPS WITH OTHER
SCIENTIFIC AND SOCIAL
DISCIPLINES THAT ACHIEVE THE
GOAL WE'RE LOOKING FOR AND THE
FOURTH IS TO INNOVATIVE ACROSS
THE RESEARCH PROGRAM.
NEXT SLIDE.
SO THE WORKING GROUP HAS BEEN
ENGAGED AT A BREAK NECK PACE
OVER THE PAST SEVERAL MONTHS AND
THEY HAVE DEVELOPED AN NIH-WIDE
STRATEGIC FRAMEWORK FOR CLIMATE
CHANGE HEALTH.
AND TO DEVELOP THIS FRAMEWORK,
THEY USE THE OVER 180 RESPONSES
TO THE RFI AND THERE WAS FROM
ALL THE WORKING GROUP MEMBERS,
MANY OF THEM WERE FROM HEART,
LUNG AND BLOOD AT A STRATEGIC
WHITE BOARDING SESSION THAT
HAPPENED IN LATE SEPTEMBER.
AND THE FRAMEWORK ALSO INCLUDED
A CONSIDERATION OF THE PORTFOLIO
AND LANDSCAPE ANALYSIS THAT WERE
CONDUCTED.
SO THE WORKING GROUP CREATED
WHAT WE'RE CALLING THIS
CENTERPIECE DIAGRAM, AND THE
PURPOSE IS TO ILLUSTRATE THE
FRAMEWORK.
SO THE FLAME WORK IS BASED ON 4
DIFFERENT ELEMENTS WHICH INCLUDE
HEALTH EFFECTS ISSUES AS
GARI.E., INDICATED, HEALTH
EQUITY AS TRAINING AND CAPACITY
BUILDING AND TRAINING AND
SCIENCE AND THE AT THE CENTER IS
THE FOCUS, IT'S
TRANSDISCIPLINEAR SKPE BAKUGAN
TRANSFORMATIVE RESEARCH TO MAKE
THIS HAPPEN.
SO LET'S SEE, CAN WE CLICK 1
MORE TIME?
NOPE, NOT WORKING.
THE ANIMATION IS NOT WORKING SO
YOU SEE THE BLUE BAND HERE
HIGHLIGHTS THE WORK THAT THE
WORK WILL BE DONE WITH CROSS
SECONDER COMMUNITY AND ISHT
AGENCY PARTNERSHIPS AND THE COGS
ON THE CIRCUMFERENCE ARE MEANT
TO ILLUSTRATE SPECIFIC TYPES OF
SCIENCE THAT WILL NEED TO BE COB
DUCTED TO SUPPORT THE FRAMEWORK.
AND AS CAN YOU SEE, THE RESEARCH
AREAS ARE TRULY
MULTIDISCIPLINARY IN NATURE.
GARY TALKED ABOUT SOME OF THESE
AND THEY RANGE FROM BASIC
MECHANISTIC RESEARCH TO
BEHAVIORAL SOCIAL SCIENCE
RESEARCH, EPIDEMIOLOGY AND
PREDICTIVE MODEL.
ALL THE WAY TO ADAPTATION
RESEARCH, THERE'S A LOT TO BE
DONE AND IT WILL REQUIRE THIS
TRANSDISCIPLINARY, VERY
TRANSFORMATIVE, INNOVATIVE
APPROACHES TO GET THIS DONE.
SO THE GOOD NEWS IS, THAT WE
TOOK THIS CLIMATE CHANGE IN
HEALTH CONCEPT FOR CLEARANCE AT
A SPECIAL SESSION OF THE NIEHS
COUNCIL ON NOVEMBER 29th, AND
THANK YOU GARY FOR JOINING US
FOR THAT SESSION.
AND I'M PLEASED TO,A NOUNS THAT
WE OBTAIN CONCURRENCE FROM
COUNCIL SO WE ARE READY TO GO.
AND BEFORE I GO ON, I DO WANT TO
POINT OUT THAT WE HAVE NOW
CREATED AN NIH WEBSITE, SO IF
YOU ARE INTERESTED IN THIS
TOPIC, AND YOU WANT TO LEARN
MORE, WWW.N
IH.GOV/CLIMATEANDHEALTH.
SO TAKE A LOOK AND LET US KNOW
WHAT YOU THINK.
NEXT SLIDE.
AND SPEAKING OF DEPLOYING THE
MONEY, THE APPROACH WE'RE
PROPOSING TO USE FOR THE
$100 MILLION IS REALLY TO USE,
YOU KNOW A HUNDRED MILLION
DOLLARS IS A NICE CHUNK OF
CHANGE BUT IT'S NOT A LOT OF
MONEY.
SO WE WANT TO USE IT AS A
CATALYST TO IMPLEMENT NIH-WIDE
CLIMATE CHANGE AND HELT WERE.
THE FOCUS WILL BE ON BUILDING
TRANSDISCIPLINARY TEAMS WITH A
LOT OF COMMUNITY ENGAGEMENT AND
WE'RE DISCUSSING SPECIFIC
FUNDING MODELS WITH THE
EXECUTIVE COMMITTEE.
SO WAWE'RE NOT THERE YET, WE
DON'T KNOW EXACTLY WHAT WE'RE
GOING TO BE DOING, THE WORK IS
VERY ACTIVELY UNDERWAY, AND WE
DON'T HAVE THE MONEY YET BUT WE
WANT TO BE READY TO DISTRIBUTE
THE FUNDS ACROSS THE NIH WHEN
HOPEFULLY THE FUNDING WILL
ACTUALLY ARRIVE ONCE WE GET AN
FY22 BUDGET.
SO NIEHS EXPECTS TO PROVIDE
FUNDING AND TO PARTNER WITH
OTHER ICs INCLUDING HEART LUNG
AND BLOOD.
AND SOME OF THE MECHANISMS WE'RE
DISCUSSING WITH THE EXECUTIVE
COMMITTEE.
AGAIN WE HAVEN'T FINALIZED ON
THIS WHY THE BUT SOME OF THE
THINGS WE'RE DISCUSS IS TO
INCLUDE SUPPORT FOR ADMINISTRATE
OF SUPLEAPTS TO EXISTING GRANTS
AND PROVIDING SUPPORT FOR SOME
OF THE UNSOLICITED PROPOSALS
THAT ARE COMING IN ACROSS THE
NIH THAT ARE NOT QUITE GETTING
THE FUNDING WISE.
SO WE'RE EXPLORING THE
EXCELLENCE OF OF FLAGSHIP
CENTERS PROGRAM THAT FOSTERS
TEAM SCIENCE ACROSS MULTIPLE
DISCIPLINES WITH EXTENSIVE
COMMUNITY ENGAGEMENT.
THE NOSIs TO BROADLY ADVERTISE
THE INTONIGHT EXPAND THE CLIMATE
CHANGE AND HEALTH RESEARCH, AND
TO DO THIS AGAIN ACROSS THE NEYE
H SO WE'RE CONSIDERING
SUPPORTING CONFERENCES AND
WORKSHOPS WHICH WE FEEL WILL
ENHANCE AWARENESS AND KNOWLEDGE
OF THE OF THE CLIMATE CHANGE AND
HEALTH THARCH IS BEING
CONDUCTED.
SO THE WO,ING GROUP IS ALSO
EXPLORING WAYS TO BUILD MODEST
WERE CAPACITY ACROSS OUR
INTRAMURAL PROGRAMS ACROSS THE
NIH.
I THINK THERE'S A RECOGNITION OF
THE EXECUTIVE COMMITTEE THAT
THERE'S SOME REAL QUALITY
SCIENCE THAT COULD BE DONE IN AN
INTEGRAL PROGRAM THAT COULD
DOVETAIL WITH THAT THAT HAPPENS
PRIMARILY IN THE EXTRAMURAL
COMMUNITY.
SO THE ACTUAL NATURE OF AN
EPITHELIAL RAMURAL PROGRAM WILL
NEED TO BE DEVELOPED.
SO OVERALL WE'RE WORKING TOWARDS
SUPPORTING THE TRANSDISCIPLINARY
TEAMS, LOTS OF COMMUNITY
ENGAGEMENT AND WE'RE HOPING TO
FUND THE RESEARCH THAT FOCUSES
ON RESEARCH THEMES AND AREAS
THAT WERE ILLUSTRATE IN THAT
STRATEGIC FRAMEWORK THAT BOTH
GARY AND I SHOWED YOU AND TAKE A
LOOK AT THE WEBSITES.
SO IF YOU'RE INTERESTED IN
LEARNING MORE.
AND I GUESS JUST ULTIMATELY, WE
HOPE THAT OUR EFFORTS WILL HELP
BUILD RESILIENCE AND THROUGH
REDUCE THE IMPACT OF CLIMATE
CHANGE AND THE POPULATIONS
AROUND THE WORLD WHOSE HEALTH
AND MOST IMPACTED BY CLIMATE
CHANGE.
SO THE BOTTOM LINE IS THAT IF
YOU ARE INTERESTED, STAY TUNED,
WE WILL BE WORKING VIGOROUSLY
WITH MY PARTNERS ON THE
EXECUTIVE COMMITTEE, THE WORKING
GROUP, THE STEERING COMMITTEE
AND WE WILL GET OUT INFORMATION
TO ALL OF YOU AS QUICKLY AS WE
CAN AND LET'S HOPE THAT ONCE WE
GET A BUDGET WE WILL HAVE
FUNDING TO HELP SUPPORT SOME OF
THE IDEAS THAT WE HAVE.
SO BEFORE I GO TO THE NEXT SLIDE
PLEASE, BEFORE I OPEN THIS FOR
DISCUSSION I WANT TO ACKNOWLEDGE
ALL MEMBERS OF THE EXECUTIVE
COMMITTEE, OF COURSE GARY IS
THERE WITH US, DIANNA BIANCHI,
ROGER GLASS FROM FOGARTY
INTERNATIONAL, JOSH GORDON FROM
NIMH, ELISEO, PEREZ-STABLE FROM
DIRECTOR OF NIMHD AND SHANNON
ZENK WHO IS THE NEW DIRECTOR OF
THE NURSING INSTITUTE AND THERE
WERE A LOT OF PEOPLE INVOLVED IN
THIS.
SO IT'S NOT JUST THE OTHER
EXECUTIVE COMMITTEE MEMBERS AND
JOSH ROSENTHALL AND COLEMAN, WE
HAVE MEMBERS OF THE STEERING
COMMITTEEOT SLIDE AND LOTS OF
OTHER PEOPLE INVOLVED AND
PULLING THINGS TOGETHER SO THAT
WE'RE MOVING AHEAD.
WE EXPECT TO CONTINUE TO BE
ONERATING AT BREAK NECK PACE TO
TAKE ON THIS HUGE CHALLENGE OF
CLIMATE CHANGE AND HEALTH.
SO NEXT SLIDE.
SO I WANT TO THANK ALL OF AND
YOU GARY THANK YOU IN PARTICULAR
FOR THIS OPPORTUNITY TO BUILD ON
THE GREAT COMMENTS THAT YOU MADE
AT THE BEGINNING AND AGAIN,
THANK YOU FOR THE EFFORTS YOU'VE
BEEN SPENDING OR THE TIME AND
THE EXPOSURE TO RADIATIONS
YOU'VE MADE ON THE EXECUTIVE
COMMITTEE SO TOGETHER WE CAN
MAKE SOME PRETTY REMARKABLE
THINGS HAPPEN.
SO I'M HAPPY TO TAKE ANY AND ALL
QUESTIONS AND I SEE THIS GWEN
HAS TURNED ON HER CAMERA SO GWEN
IS ALSO HERE AND THANK YOU FOR
ALL OF YOUR CONSIDERABLE EFFORTS
TO KEEP ALL OF THE MOVING PARTS
WORKING IN SYNCHRONY.
SO ANY QUESTIONS?
>> PLEASE RAISE YOUR HAND SO
THAT DR. WOYCHIK CAN SEE YOU
BECAUSE IT BRINGS YOU TO THE TOP
OF THE PARTIT PANTS LIST, FOLKS.
I WILL SAY I SEE A COMMENT FROM
DR. CHEN DEFOE, AND JEN YOU WANT
TO ASK YOUR QUESTION?
>> SURE.
I'M NOT SURE I CAN GET MY VIDEO
ON HERE BUT THIS IS REALLY
EXCITING.
I'M JEN DEVO, I CHAIRED FAMILY
MEDICINE AT OHSU AND ALSO LEAD
NCI-FUNDED IMPLEMENTATION
SCIENCE CENTER AND SO, YOU KNOW
MANY OF US ARE EXCITED ABOUT
THIS INITIATIVE AND HOPING TO
CONTRIBUTE SO I KNOW YOU'VE
GOT--YOUR INFRASTRUCTURE SET UP
AND YOU'RE WAITING FOR FUNDING
BUT WE WOULD JUST LOVE TO HEAR
FROM YOU WHAT YOUR CRYSTAL BALL
SHOWS AS FAR AS LIKE A YEAR O 2
YEARS IN THE FUTURE WHERE WE CAN
BEST CONTRIBUTE OR WHERE YOU
MIGHT NEED ADDITIONAL HELP.
>> I WILL MAKE A FEW COMMENTS
AND THEN I WILL PREPARE GWEN TO
CHIME IN HERE AS WELL BECAUSE
SHE AT THE INTERSECTION OF MANY
OF THE DIFFERENT ACTIVITIES THAT
ARE HAPPENING, BUT YOU KNOW WE
WANT EVERYONE TO GET ENGAGED IN
THIS, INTELLECTUALLY GET ENGAGED
WITH US, WORK WITHIN YOUR
INSTITUTES.
GARY IS CLEARLY SUPPORTIVE OF
THE WORK THAT'S HAPPENING.
WE WILL BE WORKING WITH GARY AND
OTHERS ON THE EXECUTIVE
COMMITTEE, GWEN AND MEMBERS OF
THE STEERING COMMITTEE AND THE
WORKING GROUP TO REALLY PULL
TOGETHER DIFFERENT MECHANISMS OF
HOW TO DEPLOY THIS CATALYTIC
MONEY TO START MAKING SOME
THINGS HAPPEN.
SO STAY TUNED WITH US BUT I
THINK MORE IMMEDIATELY THERE ARE
OPPORTUNITIES YOU WANT TO ROLL
UP YOUR SLEEVES, THERE MAY BE AN
OPPORTUNITY--
>> SO WE'RE TRYING TO BRING
RESEARCH PARTNERS, AND
INTERNATIONAL COMMUNITIES INTO
THIS BIG ENTERPRISE AND
CURRENTLY ALL OF THE INNITUTES
ARE ACCEPTING APPLICATIONS IN
THE CLIMB 8 CHANGE AND HEALTH
SPHERE.
WE'RE WORKING WITH THE CENTERS
FOR SCIENTIFIC REVIEW AND MAKING
SURE THAT GRAPTS THAT COME IN
THROUGH THE REGULAR COUNCIL
ROUND UNSOLICITED ARE FAIRLY
REVIEWED AND YOU KNOW WE WANT TO
SEE MORE OF THIS HAPPEN.
AND THEN OVERTIME WE WILL BE
BUILDING OPPORTUNITIES FOR TEAM
SCIENCE THAT ADDRESS THE
SOLUTIONS APPROACH TO STUDYING
THE MANY HEALTH OUTCOMES AND THE
MANY CLIMATE IMPACTS THAT LOCAL
COMMUNITIES BOTH IN THE U.S. AND
AROUND THE WORLD SO IT SOUNDS
LIKE YOUR AREA OF SCIENCE,
IMPLEMENTATION SCIENCE IS IN OUR
COG DIAGRAM AND SOMETHING WE'RE
ALSO INTERESTED IN AND LET YOU
KNOW THAT NIEHS IS HOLDING A
WORKSHOP AT THE END OF FEBRUARY
ON IMPLEMENTATION SCIENCE AND
HOW WE CAN BRING THAT DISCIPLINE
INTO THE ENVIRONMENTAL HEALTH
SCIENCE SPACE.
SOPHISTICATEDY WE INVITE TO YOU
JOIN US IF ARE THAT AS WELL.
>> GREAT.
DOES THAT ANSWER YOUR QUESTION?
>> YEAH, THANK YOU SO MUCH AND I
WILL STAY TUNED AND WATCH FOR
OTHER OPPORTUNITY SAYS AS THEY
COME OUT.
>> OKAY, TERRIFIC.
ANY OTHER COMMENTS OR QUESTIONS.
GARY ANYTHING FROM YOU?
>> THANK YOU SO MUCH RICK,
REALLY APPRECIATE YOU SHARING
THE CCH PLAN, APPRECIATE YOUR
LEADERSHIP AND THAT OF YOUR
STAFF IN THIS, ACTUALLY I JUST
WANT TO RIFF ALET BIT OFF OF
DR. DEVOW'S COMMENT AND QUERY
AND MAYBE SWITCH IT AROUND TO
HER A BIT AS AN EXPERT IN
IMPLEMENTATION SCIENCE AS WAS
ALLUDED TO BY GWEN, THIS COULD
BE AN IMPORTANT AREA.
DO YOU HAVE ANY THOUGHTS
DR. DEVOW ABOUT ABOUT THIS
INTERNATIONAL CLASSIFICATION
GRAITIONZ OF THE CLIMATE CHANGE
DIMENSION TO WHAT IMPLEMENTATION
SCIENCE YOU DO AND THE NETWORKS
YOU HAVE, SO FOR EXAMPLE, YOU
KNOW 1 OF THE THINGS THAT WE
WERE AT LEAST INTRIGUED ABOUT IS
YOU KNOW, HOW DO YOU GET THAT
EXPOSURE INFORMATION IN A WAY
THAT ACTUALLY MIGHT INTERSECT
WITH CLINICIANSOT GROUND AND HOW
THEY--LET'S SAY THEY ARE
TREATING ASMATICS AND AGAIN THAT
INTERSECTION OF BRINGING THE
CLIMATE CHANGE, THOSE DRIVERS,
THOSE EXPOSURES TO THE HEALTH
CONTEXTOT GROUND IN THE REAL
WORLD WHERE YOU WORK.
ANY THOUGHTS ABOUT THAT EITHER
FROM A DATA STANDPOINT OF WHAT
MIGHT NEED TO BE IN AN EHR OR
WHAT EXPOSURE DATA WE MAY NEED
TO GET AT A MORE GRANULAR LEVEL
THAT COULD INFLUENCE PRACTICE ON
THE GROUND, FRONT LINES, OVER?
>> YEAH, I WAS ALREADY THINKING
ABOUT HOW DO WE IMPROVE OUR
SURVEILLANCE SYSTEMS AND AGAIN
THIS IS WHERE THE
TRANSDISCIPLINARY SCIENCE COMES
INTO PLAY BECAUSE
ENVIRONMENTALLY THERE'S A LOT ON
THOSE MAPS YOU SHOWED AND
UNDERSTANDING ABOUT THE
COMMUNITIES WHERE PEOPLE LIVE,
WORK AND PLAY, AND THEN IN THE
HEALTHCARE SYSTEM, I WAS ALREADY
THINKING, YOU KNOW WE HAVE THIS
LARGE CENTER OF COMMUNITY HEALTH
CENTERS AND OCHEN AND LARGE
HEALTH RECORD EXPSES MANY OF
WHOM ARE PATIENTS IN THESE
COMMUNITIES AND POPULATIONS AND
WE HAVE FLEDGLING WORK ON
COMMUNITY VITAL SCIENCE AND
BRINGING THOSE IN THE HEALTHCARE
SETTING IN THE SAME WAY WE'RE
BRINGING IN BIOMETRIC
INFORMATION AND GENETIC
INFORMATION.
WE'RE ALSO BRINGING IN THOSE
COMMUNITY SOCIAL DETERMINANTS OF
HEALTH OR COMMUNITY VITAL SIGNS
WE LIKE TO CALL THEM AND
UNDERSTANDING HOW THAT'S
IMPACTING A PATIENT'S HEALTH BUT
I REALLY DO THINK WE COULD BUILD
A NATIONAL SURVEILLANCE SYSTEM
THAT BRINGS TOGETHER THE
CLINICAL DATA THAT WE HAVE IN
REALTIME AS FAR AS EXPOSURE DATA
AND BETTER UNDERSTAND HOW THESE
HOT SPOTS OR COLD SPOTS ARE AND
MOW WE BETTER ADDRESS THEM NOW
AND MITIGATE SOME OF THE LONGER
TERM I AM NOT PACTS ON HEALTH.
I THINK THERE'S A LOT ORDER
BUILT AND SO WE DON'T HAVE TO
START FROM SCRATCH BUT REALLY
PULLING TOGETHER SOME PRETTY
AMAZING SURVEILLANCE SYSTEMS AND
THE ABILITY TO SHOW OUR POLICY
MAKERS WHAT'S HAPPENING IN
REALTIME.
AND IDENTIFY POPULATIONS THAT
NEED MORE AND URGENT ATTENTION.
>> GREAT.
>> OVER.
>> GARY, I SEE THAT--SO GETTING
THAT INTO THE HEGHT RECORDS AND
THEN CROSS REFERENCING THAT TO
GIS DATA AND THEN BELLING THE
INFORMATICS TOOLS TO BE ABLE TO
BETTER UNDERSTAND WHAT TYPE OF
ENVIRONMENTAL EXPOSURE IS
SOMEONE THEY MAY HAVE BEEN
SUBJECTED TO BASED ON WHERE THEY
LIVE AND WHERE THEY WORK.
SO IT'S JUST--THERE'S A LOT OF
WORK TO BE DONE AND GARY I KNOW
YOU KNOW THAT WE'VE BEEN
SPENDING A LOT OF TIME ON THE
WHOLE EXPOSE OMICs CONCEPT AND
HOW DO YOU DO THAT EXPERIMENT?
AND WHAT ARE THE INTEGRAL
COMPONENTS TO THAT SO WE'VE HAD
A LOT OF DISCUSSIONS IN THE
ENVIRONMENTAL HELT SCIENCES
COMMUNITY TO BRING TOGETHER I
CALL IT OPERATIONAL WITH THE
EXPOSE OME, AND THEN IF GARY
WANTS TO DO THIS EXPERIMENT, HOW
DO YOU DO IT IN AND THEN ALSO
GLOBAL DATA INFRASTRUCTURE IN
PLACE TO CAPTURE THAT
INFORMATION SO THAT PHYSICIANS
CAN GET ACCESS THORS THIS
INFORMATION, SO WE'RE WORKING ON
ON THAT AND I'M INTERESTED IN
WORKING WITH NHLBI AND LET'S
KEEP THE DIALOGUE GOING AND A
LOT OF WORK WE HAVE TO DO.
SO GEORGE, I SEE YOU'VE BEEN
PATIENTLY WAITING WITH YOUR HAND
UP.
DID YOU HAVE A COMMENT OR
QUESTION.
>> YES, I DO HAVE A QUICK
COMMENT.
THANK YOU VERY MUCH, THIS IS HAS
BEEN AN OUTSTANDING
PRESENTERRATION, VERY, VERY
CLEAR AND TRULY EXCITING.
FIRST I JUST WANT TO SAY THAT WE
ARE REALLY PLEASED WITH A VERY
COMPREHENSIVE WAY IN WHICH YOU,
GARY AND THE NIH LEADERSHIP HAVE
BEEN APPROACHING THIS.
I ALSO WANT TO MENTION THAT
SEVERAL OF US AT NHLBI HAVE BEEN
WORKING WITH GWEN AND THE
STEERING COMMITTEE AND WE'RE
PLEASED WITH THE RECEPTION AND
SUPPORT WE'VE RECEIVED, FINALLY,
IT'S REALLY THRILLING NOT JUST
TO SEE THE IMPLEMENTATION
SCIENCE AS A BUT RISK
ASSESSMENTS IMPORTANT PART OF
YOUR COG WHEEL BUT ALSO YOUR
MENTION OF THE COMMUNITIES THAT
HAVE BEEN DISPROPORTIONATELY
IMPACTED.
THESE ARE THE SAME COMMUNITIES
THAT HAVE BEEN
DISPROPORTIONATELY IMPACT BIDE
COVID AND WE'RE HOPING THAT THE
NIH WIDE PLATFORM WE BUILT ARE
USING COMMUNITY ENGAGED RESEARCH
AND ACTIVELY ENGAGING COMMUNITY
BASED ORGANIZATIONS, THE BOOTS
ON THE GROUND, IN THE RURAL
AREAS, AND I WAS JUST CLIL
THRILLED THAT DR. DEVOE SPOKE
OUT BECAUSE THAT PLATFORM
ENABLES US TO ENGAGE FAMILY
MEDICINE, PRIMARY CARE AND THE
RURAL HEALTH CENTERS AND
HEALTHCARE FACILITIES SO IN
SHORT WE HAVE GREAT EXPECTATIONS
OF THIS AND SO WE WOULD BE
ACTIVELY WORKING WITH YOU AND
LOOK FORWARD TO THE SUPPORT
WE'VE ALREADY RECEIVED, THANK
YOU.
>> WELL GEORGE, I WANT TO
REINFORCE THAT IT'S BEEN GREAT
WORKING WITH YOU, YOUR
COLLEAGUES AND OTHERS AT NHLBI,
AS WELL AS OTHERS ACROSS THE
NIH.
THE WHOLE ISSUE OF CLIMATE
CHANGE AND HEALTH, THERE'S A LOT
OF INTEREST, A LOT OF PASSION
AND WORKING TOGETHER, IS HOW WE
WILL GET THE JOB DONE.
AND FURTHER MORE, WORKING IN
COLLABORATION WITH OTHER FEDERAL
AGENCIES, WE WANT TO MAKE SURE
WE'RE NOT COMPETING WITH CDC AND
COMPETING WITH OTHER--WE NEED TO
BE WORKING TO DEVELOP THE TYPES
OF DATA INTEGRATION TOOLS THAT
GARY REFERRED TO IN HIS TALKS
SOPHISTICATEDY THAT THE GIS DATA
FROM NOAA, AND USGS, YOU KNOW
GETS INTEGRATE INTOED OUR
PROTOCOLS, SO A LOT OF WORK TO
DO AND I THANK GWEN FOR A LOT OF
THE HARD WORK THAT SHE'S DOING,
YOU KNOW KEEPING EVERYONE
WORKING AND SYNCHRONNING WITH
EACH OTHER, SO IT'S MORE
DIFFICULT JUST BEYOND 1 IC BUT
AS I MENTIONED THIS IS A PROBLEM
THAT'S MUCH BIGGER THAN NIEHS
AND I'M SO PLEASE THAD GARY'S
WILLING TO STEP UP AND WORK WITH
US AND WORKING TOGETHER IS HOW
WE WILL MAKE A REAL IMPACT ON
THIS ENORMOUSLY IMPORTANT AND
COMPLICATED PROBLEM.
GWEN WITH RESPECT TO COMMUNITY
ENGAGEMENT, YOU WANT TO TAKE
30-SECONDS AND KIND OF CHIME IN
HERE BECAUSE I KNOW THIS HAS
BEEN A AREA OF PERSONAL PASSION
FOR YOU.
>> SURE, SURE.
YOU KNOW I WANT TO SAY THAT
NIEHS HAS A LONG HISTORY AS
WELL, WE HAVE FOCUSED FOR
SEVERAL DECADES ON BRINGING
COMMUNITIES TOGETHER, PROVIDING
THEM WITH INFORMATION ABOUT
ENVIRONMENTAL HAZARDS IN THEIR
COMMUNITIES LISTENING CAREFULLY
TO WHAT CONCERNS THEY HAVE
THERE'S MANY DECADES WORTH OF
THE TOXIC LEGACY OF RACISM AND
ENVIRONMENTAL INVISITS AND WE'RE
SO EXCITED ABOUT BRINGING OUR
NETWORK TOGETHER WITH THE
NETWORKS THAT I KNOW
ARE--THEY'LL PROBABLY OVERLAP TO
SOME EXTENT BECAUSE AS YOU SAID,
THE COMMUNITIES IMPACTED BY
COVID ARE ALSO DEALING WITH
ENVIRONMENTAL RESOURCES, I WOULD
LOVE TO BRING IN OTHER LEADER
SAYS IN THE FIELD IN THE
ENVIRONMENTAL JUSTICE AND
ENVIRONMENTAL HEALTH DISPARITY
SPACE, IT'S JUST TIME FOR US TO
ALL WORK TOGETHER AND TO SEE
WHETHER THESE INTERRELATIONSHIPS
ARE HAPPENING AND HOW WE CAN
EXPAND ON THEM.
>> GREAT.
OKAY.
WELL, GARY, I DON'T SEE ANY
OTHER COMMENTS COMING IN.
>> I DON'T SEE ANY OTHER
COMMENTS EITHER.
QUICK, FOLKS IF YOU WANT TO ASK
DR. WOYCHIK, 1 MORE QUESTION,
NOW IS YOUR CHANCE.
THAT OR YOU CAN E-MAIL ME, TOO.
IT DOESN'T EPPED HERE.
>> WELL, I WANT TO THANK YOU
AGAIN FOR COMING AND SPEAKING TO
US TODAY AND GWEN ALSO FOR YOUR
PRESENCE, IT WAS WONDERFUL TO
HEAR FROM BOTH OF YOU ABOUT SUCH
AN EXCITING INITIATIVE.
I HOPE WE KEPT THE APPROPRIATION
IN SOMEWHAT OF A TIMELY FASHION,
IT WOULD BE HELPFUL AFTER ALL
THE WORK YOU INVESTED IN LAYING
THE GROUND WORK FOR US TO HIT
THE GROUND RUNNING.
THANK YOU SO MUCH FOR ATTENDING
OUR COUNCIL MEETING TODAY.
>> THANK YOU VERY MUCH, LAURA
AND GARY, THANK YOU VERY MUCH
FOR THE INVITE.
>> THANK YOU.
>> TAKE CARE, BYE, EVERYONE.
>> BYE.
>> OUR NEXT SPEAKER ACTUALLY
DR. GAIL PEARSON BUT BEFORE WE
DO THAT, I ACTUALLY HAVE
SOMETHING ON THE AGENDA
SCHEDULED FOR A 15 MINUTE BREAK.
DO YOU WANT TO TAKE A BREAK OR
WOULD RATHER JUST GO AHEAD AND
MOVE THROUGH THE AGENDA?
DID EMPLOY I'M JUST GOING TO SAY
LET'S KEEP GOING, SO WE WILL
HEAR FROM DR. GAIL PEARSON, SHE
IS THE NHBBI'S ASSOCIATE
DIRECTOR IN THE DIVISION OF
CARDIOVASCULAR SCIENCES AND
DIRECTOR OF OFFICE OF CLINICAL
RESEARCH WHERE SHE OVERSEES A
BROAD SCIENTIFIC PORTFOLIO.
I CAN TELL YOU GAIL DOES SO MANY
THINGS, I DON'T KNOW HOW SHE
FINDS TIME TO HAVE HER OWN LIFE,
AS A PEDIATRIC CARDIOLOGYST SHE
STILL SEES PATIENTS HERE AT
CHILDREN'S NATIONAL HOSPITAL IN
D. C., SHE A PARTICULAR INTEREST
IN PEDIATRIC CARDIOVASCULAR
RESEARCH AND SHE'S PASSIONATE
ABOUT ALL OF THESE THINGS.
SHE'S CURRENTLY THE NHLBI
REPRESENTATIVE TO A NUMBER OF
EFFORTS INCLUDING THE TRANSNIH
PEDIATRIC CONSORTIUM AND THE
INCLUDE PROJECT, A TRANSNIH DOWN
CENTERED RESEARCH PROGRAM, SHE'S
HERE TODAY PRESENTING THE
TRIENNIAL INCLUSION PREPORT TO
YOU, JOINING DR. PEARSON IS MISS
KATHRYN KAVOUNIS, OFFICE WITH
THE CLINICAL RESEARCH AND
SPECIALIZES IN INCLUSION
MONITORING, HUMAN SUBJECTS
PROTECTIONS AND PORTFOLIO
ANALYSIS, SO WELCOME GAIL AND
KATIE.
THANK YOU IN ADVANCE FOR WHAT
YOU WILL BE TELLING US.
>> THANK YOU.
I'M HAVING--I SEE MY SLIDES BUT
I'M NOT SURE YOU DO.
>> THERE'S A BUTTON UP LEFT THAT
SAYS FROM BEGINNING, CLICK IT.
>> AH, AND THEN SWITCH MUCH
MPLEGHT.
>> YEAH, SWITCH.
>> YEAH, SWITCH?
OKAY, HOW ARE WE NOW?
>> PERFECT.
>> SO I'M PLEASED TO BE HERE
TODAY TO PRESENT THIS IMPORTANT
REPORT TO THE COUNCIL MEMBERS.
I'M GOING TO BE JOINED IN THE
PRESENTATION AS DR. MOEN NOTED
BY KATIE KAVOUNIS, WHO IS THE
POINT PERSON WITHIN NHLBI PER
ALL INCLUSION ACTIVITIES AND
ALSO REGULARLY ADVISES THE NIH
OFFICE OF EXTRAMURAL RESEARCH
AND REPRESENTS NHLBI IN TRANSNIH
INCLUSION ACTIVITIES.
SO FOR THIS PRESENTATION, WE
WILL GO THROUGH AN OVERVIEW OF
THE TRIENNIAL REPORT AND NIH
INCLUSION POLICY.
KATIE WILL PRESENT THE ACTUAL
NHLBI DATA I WILL TALK ABOUT A
FEW NIH AND LBI INITIATIVES AND
THEN THERE WILL BE OPPORTUNITY
FOR DISCUSSION.
SO THE TRIENNIAL REPORT, THIS IS
A REPORT THAT EACH INSTITUTE
CONTRIBUTES TO AN OVERALL NIH
REPORT, SO THAT CONGRESS CAN
UNDERSTAND WHAT WE'RE DOING IN
THE WAY OF INCLUSION FOR GENDER
RACE AND ETHNICITY IN OUR
CLINICAL STUDIES.
SO YOU'RE GOING TO HEAR TODAY, A
HIGH LEVEL SUMMARY OF THE NHLBI
REPORT AND THE ROLE OF THE
COUNCIL IS TO HELP THE INSTITUTE
CERTIFY THAT NHLBI IS IN
COMPLIANCE WITH ALL OF OUR
INCLUSION POLICIES,--IS THE
UPDATER PINNING STILL OF MANY OF
OUR POLICIES.
THAT IT'S REQUIRED THAT WOMEN
AND MINORITIES BE INCLUDE INDEED
ALL CLINICAL AND RESEARCH
STUDIES THAT PHASE 3 CLINICAL
TRIALS INCLUDE VALID
AND--WHOOPS, SORRY.
INCLUDE VALID ANALYSIS BY SEX,
GENDER, RACE AND ETHNICITY WHERE
APPROPRIATE AND THEN AS I JUST
MENTIONED THE ADVISE RECOUNCIL'S
HAVE THE--ADVISORY COUNCIL'S
HAVE THE ROLE OF REVIEWING AND
PROVIDING INPUT.
NIH CURRENT POLICIES AND
GUIDELINES, AGAIN ATTEMPT TO
INSURE THE APPROPRIATE INCLUSION
OF WOMEN AND MINORITIES AND
REPORTING OF ANALYSIS BY SEX,
GENDER, RACE AND ETHNICITY IS
NOW REQUIRED TO
CLINICALTRIALS.GOV.
IN ADDITION, MORE RECENTLY
THERE'S BEEN AN EMPHASIS ON
INCLUSION OF INDIVIDUALS IN
CLINICAL STUDIES ESPECIALLY
CHILDREN AND OLDER ADULTS.
SO EFFECTIVE AT THE BEGINNING OF
THIS CURRENT REPORTING PERIOD,
THE NIH POLICY ON INCLUSION
ACROSS THE LIFE SPAN, INCLUDED 3
KEY CHANGES, EXPANSION OF
INCLUSION REPORTING TO ALL AGES,
CLARIFYING ACCEPTABLE REASONS
FOR EXCLUSION AND IMPLEMENTED
AN ANNUAL REQUIREMENT TOY BEGIN
REPORTING DEIDENTIFIED
INDIVIDUAL--SORRY.
TRIGGER FINGER.
INDIVIDUAL LEVEL PARTICIPANT
DATA INCLUDING AGE OF
ENROLLMENT, SEX, GENDER, RACE,
ETHNICITY AND KATIE WILL TALK A
BIT MORE ABOUT THAT.
SO YOU'RE ALL FAMILIAR WITH THE
NIH--NHLBI'S STRATEGIC VISION
APPROACH.
ALL OF THE OBJECTIVES NOTED HERE
CONTAIN ASPECTS OF INCLUSION AND
DIVERSITY AND OF COURSE
DIVERSITY IS IMPORTANT IN ALL OF
THE RESEARCH WE DO, BUT,
OBJECTIVE 3, SPECIFICALLY CALLS
OUT INVESTIGATING FACTORS THAT
ACCOUNT FOR DIFFERENCES IN
HEALTH AMONG POPULATIONS.
SO THIS HAS BEEN A KEY PILLAR OF
NHLBI'S APPROACH FOR QUITE
SOMETIME.
NHLBI HAS PROCEDURES FOR
EVALUATING INCLUSION.
THIS IS THE JOINT EFFORT BETWEEN
PEER REVIEW, PROGRAM STAFF AND
GRANTS MANAGEMENT.
SO WOE ASK THINGS LIKE IS THE
INCLUSION PLAN JUSTIFIED IN
TERMS OF THE SCIENTIFIC GOALS
AND RESEARCH STRATEGY.
DOES IT PROPOSE PROPORTION OF
WOMEN MINORITIES AND RELEVANT
AGE GROUPS, MATCHED THE
PREVALENCE AND DISEASE OR
CONDITION BEING STUDIED.
AND THEN WHEN ALL THE GRANTS
SUBMIT THEIRANNUAL PROGRESS
REPORTS, THEIR REVIEWED TO SEE
WHETHER ENROLLMENT MET THE PLAN.
SO THIS IS REPORTED TO CONGRESS
AND REPORTED ON A PUBLIC WEBSITE
AND COVERS FISCAL YEARS 2019,
2020 AND 2021.
IT INCLUDES GRANTS AND CONTRACTS
WITH HUMAN SUBJECTS IT INCLUDING
EXTRAMURAL WHICH MAKES UP THE
BULK OF REPORTING AS WELL AS
INTERIM AND ENROLLMENT AND
EXCLUDES ANALYSIS OF EXISTING
DATA SETS AND THIS IS WHAT THE
REPORT LOOKED LIKE THE LAST TIME
COUNCIL REVIEWED THIS AND
DR. GIBBON'S CERTIFIED IT AND
THIS IS WHAT WILL OCCUR AGAIN
THIS YEAR AFTER YOUR REVIEW.
I WOULD LIKE TO ACKNOWLEDGE
KATIE'S INCREDIBLE WORK IN
PUTTING TOGETHER THE DATA ON THE
SLIDES YOU'RE ABOUT TO SEE.
SO TO START OFF WITH WE JUST
WANTED TO SUMMARIZE NHLBI
ENROLLMENT IN ALL HUMAN SUBJECT
STUDIES THROUGH A FISCAL YEAR
2019 THROUGH 2021.
THE RED IS U.S. PARTICIPANTS AND
THE BLUE IS NON U.S.
PARTICIPANTS.
YOU WILL SEE THERE'S A BIG BUMP
IN 2020.
THIS WAS DUE TO 3 EHR HOSPITAL
BASED GRANTS THAT HAD HUGE
ENROLLMENT.
AND THEN YOU PROBABLY WON'T BE
SURPRISED ABOUT A DECREASE IN
ENROLLMENT IN 2021, THIS IS DUE
TO A COUPLE OF THE REALLY LARGE
STUDIES, FINISHING BUT ALSO OF
COURSE DUE TO IMPACTS FROM THE
COVID PANDEMIC.
>> HI, GAIL, I WOONG
STRAIGHTENED OUT THE ISSUES, ARE
YOU ABLE TO HEAR ME NOW?
>> YES, GREAT.
>> DO YOU SEE THE SLIDE THAT
WE'RE ON?
>> I DO, YES, I'M SORRY,
EVERYONE.
>> THAT'S OKAY.
PLEASE.
>> SO, THANK YOU FOR YOUR
PATIENCE.
IN TERMS OF THE ENROLLMENT FOR
OUR PHASE 3 TRIALS, AS GAIL
MENTIONED DUE TO COVID, WE'VE
HAD A DECLINE IN ENROLLMENT, THE
BIG BUMP WE SEE IN 2019 IS REAL
RELATED TO A LARGE TRIAL, WOMEN
ONLY TRIAL THAT ENDED IN 2019,
SO IN 2020 AND 2021, WE WERE
BACK TO OUR MORE REGULAR LEVEL
OF ENROLLMENT IN CLINICAL TRIALS
BUT YOU'LL NOTICE THAT WE DID
HAVE A STUDY INCREASE IN FOREIGN
ENROLLMENT AND LATER ON, YOU
WILL SEE THAT THAT IMPACTS OUR
RACE AND ETHNICITY DATA IN 2021
AS WELL.
NEXT SLIDE.
SO FOR OUR SEX AND GENDER PIE
DIAGRAMS HERE, ALL OF THE
DEMOGRAPHICS ARE MEANT TO BE
PARTICIPANT REPORTED,
SELF-REPORTED, SO, DEPENDING ON
THE AIMS OF THE STUDY, AN
INVESTIGATOR MAY ASK FOR EITHER
SEX OR GENDER, BUT FOR THIS
DATA, THOSE ARE COMBINED AS
SEX/GENDER AND WE'RE PRETTY
CONSISTENT OVER THE YEARS.
WE HAVE A SLIGHT DECREASE IN OUR
ENROLLMENT OF WOMEN IN 2021 AND
AGAIN, I THINK THAT'S MOSTLY DUE
TO THE COMPLETION OF OUR LARGE
WOMEN ONLY TRIAL IN THE EARLIER
YEARS AS WELL AS IMPACT OF COVID
AND THE INCREASED ROLE OF
CAREGIVERS AMONG WOMEN.
NEXT SLIDE, PLEASE.
THIS IS THE SAME SEX GENDER
BREAK DOWN BUT FOR OUR PHASE 3
TRIALS.
AND AGAIN, THAT LARGE 66%
ENROLLMENT OF WOMEN IN 2019 WAS
RELATED TO THE LARGE WOMEN-ONLY
TRIAL AND THEN WE SAW A SLIGHT
DECREASE IN 2020, AND 2021.
NEXT SLIDE.
NOW THESE COLUMNS, 1 FOR 2019, 1
FOR 2020 AND 1 FOR 2021, SHOW
THE RACIAL CATEGORIES AND AGAIN
THIS IS MEANT TO BE RECORDED BY
THE STUDY PARTICIPANTS HOW THEY
IDENTIFY IN THESE RACIAL
CATEGORIES AND FROM TOP TO
BOTTOM THE FIRST CHUNK THERE ARE
UNKNOWN OR NOT REPORTED, SO WE
STILL HAVE A LOT OF PARTICIPANTS
WHO EITHER CHOOSE NOT TO REPORT
OR DON'T FEEL LIKE THEY FIT INTO
1 OF THESE CATEGORIES.
NEXT, IS THE MORE THAN 1 RAISE
CATEGORY, FOLLOWED BY THE
BLUE--AND YOU SEE WE HAD AN
INCREASE IN 2020 OR 2021 AS
THOSE WHO IDENTIFIED AS BLACK OR
AFRICA AMERICAN.
AND WE NEXT SAW THE ASIAN
PARTICIPANTS UP TO 4.4% IN 2021.
NEXT SLIDE PLEASE.
HERE ARE THOSE SAME CATEGORIES,
BUT FOR OUR PHASE 3 CLINICAL
TRIALS.
AGAIN WE SEE ALMOST A DOUBLING
IN OUR PARTICIPANTS WHO REPORTED
AS BLACK OR AFRICAN AMERICAN, UP
TO 25.8% IN 2021, AS WELL AS
ASIAN PARTICIPANTS AT 9.2%.
AND IN OUR PHASE 3 TRIALS WE
REALLY NOTICED IN THE PAST FEW
YEARS, AN INCREASE OF FOREIGN
FORPII SYSTEMSITANTS, WE HAD A
LARGE INDOOR AIR QUALITY STUDY
IN LOW INCOME COUNTRIES AND
ABOUT HALF OF THOSE PARTICIPANTS
WERE FROM LATIN AMERICAN
COUNTRIES.
WE ALSO HAD AN INCREASE IN
TARGETED PHASE 3 TRIALS, FOCUSED
ON UNDERREPRESENTED POPULATIONS.
SO I THINK OVERALL OUR MINORITY
ENROLLMENT IN OUR PHASE 3 TRIALS
HAS REALLY IMPROVED FROM THE
PREVIOUS TRIENNIAL REPORT.
WE HAD A LOT OF FOCUS TRIAL BUT
I THINK, YOU KNOW THERE'S ALWAYS
ROOM FOR IMPROVEMENT THAT'S FOR
SURE.
NEXT SLIDE, PLEASE.
NOW THESE CHARTS ARE LOOKING AT
ETHNICITY AND THE OMB CATEGORIES
THAT INVESTIGATORS HAVE TO USE
ARE HISPANIC OR LATINO OR NOT
HISPANIC OR LATINO.
AND YOU WILL NOTICE ACROSS THE
YEARS WE HAVE A HIGH PERCENTAGE
OF UNKNOWN OR NOT REPORTED AND I
THINK A LOT OF OUR INVESTIGATORS
REPORT THAT PARTICIPANTS, A LOT
OF TIMES DON'T UNDERSTAND BEING
ASKED BOTH RACIAL AND ETHNICITY
QUESTIONS AND A LOT OF THEM END
UP SAYING UNKNOWN OR DON'T GIVE
A RESPONSE FOR THE ETHNICITY
CATEGORY.
WE DO HAVE AN INCREASE IN 2020
AND THEN, SETTLE AT ABOUT 10.7%
HISPANIC OR LATINO PARTICIPANTS
IN 2021.
NEXT SLIDE, PLEASE.
AND AGAIN HERE ARE THE ETHNICITY
PIE CHARTS IN THE PHASE 3
CLINICAL TRIALS.
AND AGAIN IN 2019, 2020, AND
2021, ARE DUE TO THE TARGETED IN
THE UNDERREPRESENTED POPULATION.
WE HAVE A LARGE CARDIOVASCULAR
TRIAL AMONG HIV POSITIVE
PARTICIPANTS THAT HAD VERY HIGH
RACIAL AND ETHNIC MINORITY
POPULATION.
AGAIN, THE INDOOR AIR QUALITY,
FOREIGN TRIAL, AND THEN WE ALSO
HAD A VERY LARGE TRIAL LOOKING
AT THE DISSEMINATION AND
IMPLEMENTATION OF THE SPRINT
TRIAL RESUMMITS.
AND THAT WAS SPECIFICALLY
TARGETED TO UNDERSERVED
POPULATION.
NEXT SLIDE.
AND BRINGING THE LENS OUT A
LITTLE BIT, THIS SLIDE
SUMMARIZES ALL OF OUR PHASE 3
TRIALS.
SO IN 2021 ALL OF OUR TRIALS,
THE SUMMARY INFORMATION THERE
SHOWED WE HAD 52% PARTICIPATION
AMONG WOMEN, IT ALSO DOMEON
STRAIGHT THAD SAME INCREASE IN
PLAQUE OR AFRICAN AMERICAN
PARTICIPANTS IN ASIAN, HISPANIC
OR LATINO PARTICIPANTS AND I
THINK IT REALLY SHOWS, NHLBI'S
COMMITMENT TO THE SUSTAINED
INVESTMENTS IN HELPING THE
INVESTIGATORS REACH OUT TO
UNDERSERVED POPULATION AND AS I
MENTIONED, I THINK A LOT OF OUR
DATA IS DRIVEN BY THESE TARGETED
STUDIES AND TRIALS BUT IT
MAY--YOU KNOW I'M WORRIED IT MAY
MASK SOME INCLUSION ISSUES THAT
WE'RE STILL HAVING IN SOME OF
OUR VERY SPECIFIC PORTFOLIOS OR
SOME OF OUR SMALLER TRIALS.
SO I THINK OVERALL THE DATA
LOOKS GOOD.
OUR INVESTIGATORS ARE WORKING
HARD AND I THINK NHLBI PROGRAM
STAFF ARE WORKING CLOSELY WITH
INVESTIGATORS TO MAKE SURE THEY
UNDERSTAND THE IMPORTANCE OF
DIVERSITY AND INCLUSION--AND
HOPEFULLY WE WILL HAVE MORE
INFORMATION FOR THOSE AS WELL.
NEXT SLIDE.
AND AS GAIL MENTIONED THE 2021
DATA IS OUR FIRST LOOK AT THE
NEW REQUIREMENTS FOR
INVESTIGATORS TO PROVIDE AGE
ENROLLMENT DATA SO EVEN THOUGH
ABOUT 26% OF OUR STUDIES
REPORTING ENROLLMENT FALL UNDER
THIS NEW REQUIREMENTS, WE HAVE
THIS FIRST LOOK AT THE DATA AND
WE'RE SEEING THAT 11% OR THESE
BLUE BARS HERE OR 11% OF THE
PARTICIPANTS FALL INTO THE LESS
THAN 18 YEARS OLD CATEGORY, WE
HAVE 37% THAT FALL INTO THE
18-64 CATEGORY AND 49% OF THE
NHLBI PARTICIPANTS WERE 65 OR
OLDER AND I THINK, YOU KNOW THIS
IS TO BE EXPECTED, A LOT OF THE
NHLBI PORTFOLIO COVERED CHRONIC
CONDITIONS AND I THINK WE WILL
BE INTERESTED TO LOOK MORE--DIVE
MORE DEEPLY INTO THIS DATA
BEFORE WE START HAVING
INFORMATION AND PERHAPS IN THE
NEXT TRIENNIAL REPORT AND WE
WILL HAVE MORE THAN 26% OF THESE
STUDIES REPORTING OUR DETAIL.
NEXT SLIDE.
>> A LITTLE BIT MORE DETAIL IN
TERMS OF THE CHILDREN WHO ARE
ENROLLED IN OUR TRIALS, THE
MAJORITY, A LOT OF THEM FALL
INTO THE 6-12 YEAR CATEGORY AND
I THINK THIS IS BASED ON A LOT
OF OUR STUDIES OR A LARGER
STUDIES AS SCHOOL BASED SO THIS
WOULD BE THE ELEMENTARY SCHOOL
POPULATION AND I THINK WE HAVE A
FEW NUTRITION STUDIES THAT ARE
LOOKING AT SCHOOL BASED
NUTRITION.
NEXT SLIDE, PLEASE.
THIS IS A BREAK DOWN OF OUR
OLDER ADULTS AND YOU WILL SEE,
THE BIGGEST CHUNKS ARE IN THIS
75-79 AND 80-84 CATEGORY.
NEXT SLIDE.
BACK TO YOU GAIL.
>> THANKS, KATIE FOR TAKING US
THROUGH THE DATA, REALLY
APPRECIATE IT.
SO I WANT TO SPEND A FEW MINUTES
NOW, GOING OVER SOME NIH AND
NHLBI ACTIVITIES RELATED TO
INCLUSION AND DIVERSITY,
DR. GIBBONS MENTIONED IN HIS
TALK, THE INSTITUTES GAINS IN
INSURING THE DIVERSE POOL OF
INVESTIGATORS ARE LEADING OUR
STUDIES PARTICULARLY IN THE
TRAINING GRANT PORTFOLIO AND OF
COURSE, WE HEARD FROM BOTH
DR. GIBBONS AND DR. WOYCHIK, THE
INCREDIBLE EFFECTS ON EQUITY AND
CLIMATE CHANGE AND PROGRAM TO
COMBAT CLIMATE CHANGE AND
INCREASE HEALTH EQUITY.
SO, IN NOVEMBER, 2019 NIH
PUBLISHED THEIR STATEMENT OF
INTEREST IN DIVERSITY AND IN
THIS NIESH H ENCOURAGED
INSTITUTIONS TO DIVERSIFY
INSTITUTION AND FACULTY
POPULATIONS TO ENHANCE THE
PARTICIPATION OF INDIVIDUALS
FROM GROUPS THAT ARE UNDER
REPRESENTED IN ALL AREAS OF
RESEARCH.
AND UNDERREPRESENTED INCLUDING
IN THIS PERSPECTIVE, RACIAL AND
ETHNIC GROUPS, INDIVIDUALS WITH
DISABILITIES, INDIVIDUALS FROM
DISADVANTAGED BACK GROUPEDS SUCH
AS HAVING BEEN HOMELESS AND
WOMEN IN ALL THE CATEGORIES
ABOVE AS WELL AS AN EMPHASIS.
THIS NOTICE AND THIS STATEMENT
WILL BE INCORPORATED IN NHLBI'S
CLINICAL FUNDING ANNOUNCEMENTS
WHEN THEY ARE RESILIENCE LEASED
LATER THIS YEAR, SO THIS IS 1 OF
THE THINGS NHLBI'S DOING.
WHEN OUR STAFF TALK WITH
INVESTIGATORS, WHEN THEY COME
INTO US WITH LARGE GRANTS WHICH
TYPICALLY INCLUDE TRIALS AND
THEY'RE REQUIRED TO HAVE A
CONSULTATION WITH THE STAFF
BEFORE SUBMISSION, WE'RE ALSO
TAKING THE OPPORTUNITY TO
DISCUSS WITH THE INVESTIGATORS,
HOW THEIR RESEARCH TEAM WILL
INSURE DIVERSE RECRUITMENT AND
THIS OFTEN RESULTS IN A CHANGE,
MEANING INCREASED DIVERSITY IN
THE RESEARCH TEAMS, AND ENHANCES
THEIR FOCUS ON RECRUITING AND
DIVERSE POPULATION.
SO I THINK IN 2016 NIH
INTRODUCED ITS POLICY ON SEX AS
A BIOLOGICAL VARIABLE, THIS HAS
BEEN LED BY JANINE CLAYTON ON
THE OFFICE OF RESEARCH HEALTH
AND THE POLARIZED VEE SUGGESTS
THAT PEOPLE DESIGN STUDIES THAT
TAKE SEX INTO ACCOUNT AND THIS
IS NOT JUST CLINICAL, THIS
IS--OR ALL HUMAN SUBJECTS THIS,
THIS IS ACROSS ALL TYPES OF
HUMAN SUBJECTS ACROSS DATA
RESEARCH AND THAT DATA BE
TABULATED SO THAT THEY CAN BE
ANALYZED AND THEN THAT,--WHICH
COVERS THE PERIOD 2019-2023,
OTHER ACTIVITIES HAVE COME OUT
OF THIS INCLUDING TRAINING
EFFORTS, AND SOME FOCUSED
FUNDING ANNOUNCEMENTS, IN 2020
DR. CLAYTON AND OTHERS PUBLISHED
AN UPDATE ON THE EFFECTIVENESS
OF THIS POLICY THAT THERE HAVE
BEEN ADVANCES, THAT COVERS
FISCAL YEARS AND THEIR GOALS ARE
TO PRINCIPALLY ADVANCE AS
RESEARCH IN THESE AREAS--ANOTHER
NIH INIT WRAATIVE, I'M SURE
YOU'RE ALL FAMILIAR WITH THE
BRAIN INITIATIVE, DESIGN TO
BETTER UNDERSTAND THE HUMAN
BRAIN, THEY ARE ACHE TAKING AN
APPROACH FOR GRANT APPLICATIONS
NOW THAT INVOLVES A PLAN FOR
ENHANCING DIVERSE PERSPECTIVES,
SO THIS REQUIRES MOST
APPLICANTS, THE BRAIN INITIATIVE
FUNDING OPPORTUNITY
ANNOUNCEMENTS, TO HAVE THIS
PLAN, WHICH MEANS THAT IN THEIR
RESEARCH STRATEGY, THEY NEED TO
INTEGRATE STRATEGIES TO ADVANCE
THE SCIENTIFIC AND TECHNICAL
MERIT OF THE PROPOSED PROJECT
THROUGH THE INCLUSION OF DIVERSE
PERSPECTIVES AND INCLUDE A 1
PAGE SUMMARY OF THESE PLANS AND
THIS PLAN WILL BE PART OF THE
SCORING OF THE APPLICATION AND
WILL BE CONSIDERED WHEN FUNDING
DECISIONS ARE MADE.
SO IN THIS APPROACH, DIVERSE
PERSPECTIVES, REFERS TO THE
PEOPLE WHO DO THE RESEARCH, WHO
PER TAIS INHIBITOR PARTICIPATE
IN A TRIAL IN THE RESEARCH, AND
THE PLACES WHERE RESEARCH IS
DONE.
AND I'M GOING TO SKIP THIS NEXT
SLIDE FOR THE SAKE OF TIME.
NIH ALSO HAS GRASS ROOTS
STRATEGY FOR INCREASING
INCLUSION AND NIH RESEARCH,
DR. LO LA [INDISCERNIBLE] FROM
THE NEUROLOGY INSTITUTE HAS SET
UP THIS SPECIAL POPULATIONS
RESEARCH FORUM, THE PURPOSE OF
WHICH IS TO PROVIDE A RESOURCE
FOR BEST PRACTICES--AND
PERSPECTIVE LATER THIS YEAR, SX
HEAT TRAFFIC INCLUDING
UNDERREPRESENTED AND RACIAL AND
ETHNIC GROUPS IN ORDER TO
IDENTIFY DISPSMS OF GOOD
PRACTICES IN THIS AREA AND SHARE
THEM ACROSS NIH.
NHLBI IS I'M SURE YOU KNOW HAS
WOMEN'S HEALTH WORKING GROUP.
AND THEY'VE BEEN VERY BUSY,
DURING THE PERIOD OF THIS
INCLUSION REPORT, WITH WORKSHOPS
AND OTHER ACTIVITIES, SO THERE
HAVE BEEN IN 2020 THERE WAS A
MATERNAL HEALTH WORKSHOP THAT
WAS TRANSNIH, AND ANOTHER
WORKSHOP ON CARDIOVASCULAR
WORKSHOP PREDICTION FROM
MATERNAL MORBIDITY IN THE
WORKSHOP LED BY NIBIB ON
TECHNOLOGY TO IMPROVE MATERNAL
HEALTH.
WE'VE ALSO HAD SEX AND GENDER
SPECIFIC PORK SHOPS INCLUDING 1
RELATED TO AUTOIMMUNE INDUCED
LUNG DISEASES.
CO TRANSACTIVATOR FOR
CARDIOVASCULAR RISK ACROSS THE
LIFE SPAN FOR POLYCYSTIC OVARY
SYNDROME.
YET ANOTHER 1 BUILDING UNIFYING
SYSTEMS OF CARE, ADDRESSING
CO-MORBIDITIES IN WOMEN AND
GIRLS AND THIS COMING JUNE,
THERE WILL BE 1 ON SEX-SPECIFIC
COVID-19 OUTCOMES AND MANAGEMENT
RELEVANT TO ALL OF THE THINGS WE
STUDY.
AS DR. GIBBONS ALLUDED TO IN HIS
EARLIER TALK, YOU PARTICIPATED
OR MANY OF YOU PARTICIPATED IN
THE COUNCIL, EEG POINT WORKING
GROUP ON CLINICAL TRIALS THAT
WAS HELD IN LATE SUMMER.
THE LARGE TO THIS GROUP WAS TO
CONSIDER INNOVATIVE WAYS TO
OPTIMIZE NHLBI CLINICAL TRIALS
AND FROM THE 2 DAYS OF
DELIBERATIONS, I PULLED OUT THE
RECOMMENDATION RELATED TO
INCLUSION, IN THIS CASE ON
INVESTIGATORS AND ON THE NEXT
SLIDE, FOR PARTICIPANTS.
SO A NUMBER OF REALLY EXCELLENT
SUGGESTIONS HERE, THAT INCLUDE
FOR INVESTIGATORS, OF HELPING
THEM FIND WAYS TO PARTNER WITH
LESS EXPERIENCE TO TRIAL
LEADERSHIP TEAMS AND NETWORKS
INCLUDING DIVERSE INDIVIDUALS AS
MEMBERS OF THE TEAM DESIGNING A
TRIAL AND FOSTERING AN ACADEMIC
ENVIRONMENT THAT PROMOTES
DIVERSITY, USE VIRTUAL
TECHNOLOGY FOR MENTORSHIP
TRAINING AND COLLABORATION AND
PEOPLE IN SMALLER INSTITUTIONS
AND UNDERREPRESENTED DON'T HAVE
THE FUNDS TO PARTICIPATE IN MEET
EXPTION PROVIDE ACCESS TO
EXPERTS, RELATED TO GEOGRAPHIC
AND RACIAL DISPARITIES, AND IN
REGARD TO PARTIC PLAN TO ANALYZE
BY AGES AND TRIALS, 1 OF THE
GOALS IS TO USE REMOTE FOLLOW UP
AND HOME VISITS AND OTHER
SIMILAR APPROACHES TO
INCORPORATE COMMUNITY ENGAGEMENT
ACTIVITIES, DR. MENSA MENTIONED
THE COMMUNITY ENGAGEMENT
ALLIANCE FOR COVID, PREVIOUSLY,
THERE ARE A LOT OF LESSONS
LEARNED THERE THAT CAN BE
INCORPORATED INTLO ALL OF OUR
TRIAL ACTIVITIES, OF COURSE,
IT'S EXTREMELY IMPORTANT TO
ESTABLISH TRUST AND EXPAND REACH
THROUGH EDUCATION INFORMATION
AND WE ARE MOVING TOWARD BEING
ABLE TO BE PRESCRIPTIVE IN
APPLICATION REQUIREMENTS SUCH AS
WHAT I MENTIONED WITH THE BRAIN
INITIATIVE.
USING PRACTICE SETTINGS TO
BETTER REVEAL SOCIAL
DETERMINANTS OF HEALTH.
THIS IS RELATED TO PART OF THE
DISCUSSION DURING DR. WOYCHIK'S
TALK ABOUT HOW TO GET SOME OF
THE INFORMATION RELATED TO
CLIMATE CHANGE INTO THE
ELECTRONIC HEALTH RECORD AND TO
INVEST IN CARE, IT'S FORTUNATE
INCORPORATE IMPLEMENTATION
SCIENCE AND TRAVEL DESIGN TO
PARTNER WITH ADVOCACY GROUPS TO
PROVIDE AGAIN, ACCESS TO EXPERTS
TO ADDRESS GEOGRAPHIC AND RACIAL
DISPARITIES IN TRAINING AND CAN
PROMOTE COMMUNITY INVOLVEMENT.
AND THAT CONCLUDES OUR REPORT.
I WOULD LIKE TO THANK YOU FOR
YOUR ATTENTION.
WE ARE HAPPY TO ANSWER ANY
QUESTIONS.
I WILL STOP SHARING NOW.
DOES ANYONE HAVE ANY QUESTIONS
FOR GAIL, COMMENTS?
>> HI, GAIL, GREAT TO SEE YOU
AGAIN.
TERRIFIC PRESENTATION.
>> THANK YOU.
>> THIS IS REALLY REMARKABLE
WORK AND I THINK THIS IS REALLY
GREAT IN TERMS OF BEING ABLE TO
SHOW WHAT'S POSSIBLE.
I KNOW IT'S OFTEN TIMES A
MULTIPRONGED EFFORT BUT WHAT
WOULD YOU ATTRIBUTE MOST TO THE
SUCCESS YOU'VE BEEN ABLE TO
ACHIEVE BOTH IN SEX GENDER,
DIVERSITY AND RACE AND ETHNICITY
AS WELL?
>> YOU KNOW THANKS FOR THE
QUESTION, KEVIN, TO ME 1 OF THE
MOST IMPORTANT THINGS IS BEING
INTENTIONAL ABOUT IT.
YOU KNOW IN THE CASE OF TRIAL
TEAMS FOR EXAMPLE, NOT JUST
ROUNDING UP THE USUAL SUSPECT SO
TO SPEAK AND HAVING FRANK
CONVERSATIONS WITH INVESTIGATORS
ABOUT THESE ISSUES.
SO I THINK SLOWLY THE STAFF ARE
LEARNING HOW TO HAVE THESE
CONVERSATIONS WITH A LOT OF
MENTORSHIP FROM THE LEADERSHIP
HERE.
I THINK THAT IT'S HIGHLY
RECOGNIZED THAT A LOT OF WHAT'S
IN OUR PORTFOLIO IS HIGHLY
INFLUENCED BY RACE, ETHNICITY
AND GENDER AND SO I THINK IT
ALMOST SOUNDS SIMPLISTIC,
OBVIOUSLY IT ISN'T BUT THIS HAS
BEEN A HIGH INSTITUTE PRIORITY
FOR YEARS AND PEOPLE ARE REALLY
PAYING AND MEMBERS OF THE
LEADERSHIP CAN TALK AND ABOUT
HOW IMPORTANT THIS APPROACH IS
AND SO, I THINK ALL OF THAT ADDS
UP EVENTUALLY AND I KNOW KATIE
IF YOU HAVE OTHER THOUGHTS OR
ANYBODY ELSE FROM NHLBI WANTS TO
PROVIDE A RESPONSE.
>> I WOULD AGREE, AND I WOULD
SAY THAT YOU KNOW MAKING AND
DEFINITELY MADE THIS MORE OF A
VISIBLE TOPIC AND YOU KNOW
MAKING IT CLEAR TO INVESTIGATORS
THAT THIS GOES INTO YOU KNOWLET
REVIEW PROCESS OF THEIR
APPLICATION AND YOU KNOW THAT
THIS IS SOMETHING THAT'S
IMPORTANT TO CONSIDER FROM THE
VERY BEGINNING DEVELOPMENT OF
THEIR STUDIES AND THEIR
PROTOCOLS.
>> DOES THAT ANSWER YOUR
QUESTION, KEVIN?
>> IT DID, THANK YOU VERY MUCH.
APPRECIATE IT.
>> THANKS.
>> ANYBODY ELSE, COMMENTS?
>> MONICA HAS A COMMENT.
THANK YOU FOR ALL YOUR
OUTSTANDING EFFORTS?
I REALLY LIKED SEEING THE
INCREASE AND OUR ABILITY TO GET
MORE REPRESENTATION FROM
UNDERREPRESENTED GROUPS IN THESE
STUDIES.
IT'S VERY, VERY IMPORTANT AND I
KNOW WE'VE HAD A LOT OF TALKS
WITHIN INSTITUTE LEADERSHIP WITH
WAYS TO APPROACH THIS, I WAS
DELIGHTED YOU WERE ABLE TO ADAPT
THE BRAIN'S APPROACH, THE BRAIN
INITIATIVE APPROACH.
IT WAS GOOD THAT WE COULD GET
THE GO AHEAD TO DO THAT ACROSS
THE NIESH H.
THERE'S BEEN A LOT OF
FRUSTRATION I THINK WITH HOW WE
CAN ACTUALLY COME OUT AND SAY
WHAT WE WANT WITHOUT RUNNING
AFOUL OF CERTAIN LEGAL MATTERS.
>> TO KEVIN'S QUESTION, WE HAD
TO INFLUENCE THE ATTORNEYS HERE
FOR SOME OF THIS.
>> REMEMBER, THIS IS ALL BEING
RECORDED.
WE HAVE MORE COMMENTS IN THE
CHAT.
JEN, DEVOE IS THANKING YOU AS
WELL AS MERCEDES IS THANKING
YOU.
OKAY.
I'M NOT SEEING ANY MORE
QUESTIONS OR COMMENTS COMING
THROUGH, BUT ALSO YOU KATIE AND
I APPRECIATE YOUR PERSEERANCE
WITH YOUR AUDIO ISSUES, I'M
DPLAD WE COULD GET THOSE
RESOLVED SO WE COULD HEAR FROM
BOTH OF YOU THIS AFTERNOON.
THANK YOU VERY MUCH FOR TAKING
THE TIME TO PUT THE REPORT
TOGETHER AND FOR PRESENTING IT
TO US.
>> MY PLEASURE, THANK YOU.
>> OKAY, SO WE HAVE 1 MORE ITEM
ON OUR AGENDA TODAY.
THAT'S MINE, WE ARE GOING TO
TALK ABOUT THE DELEGATION OF
AUTHORITIES.
WE DO THIS EVERY YEAR.
I'M SUPPOSED TO BRING TO YOUR
CONSIDERATION THE ANNUAL RENEWAL
OF THE DELEGATED AUTHORITIES,
THESE ARE THE OPERATING
GUIDANCES THAT ALLOW NHLBI STAFF
TO PERFORM SPECIFIC FUNCTIONS
WITHOUT COUNCIL INVOLVEMENT
BECAUSE OCCASIONALLY WE CAN'T
CONVENE COUNCIL TO DO CERTAIN
THINGS THEREBY WE HAVE SOME
FLEXIBILITY AND DECREASE THE
BURDEN ON THE COUNCIL, SO, I'M
GOING TO BE ASKING YOU FOR YOUR
APPROVAL OF THE DELEGATED
AUTHORITIES FOR 2022 WHICH WERE
AVAILABLE ON THE ELECTRONIC
COUNCIL BOOK AND SUMMARIZED ON
THE SLIDE AND THESE DELEGATED
AUTHORITIES REMAIN UNCHANGED
FROM THOSE APPROVED FOR 2021.
SO THE SLIDE IS UP THERE FOR
YOUR PERUSAL, IN BRIEF, WHAT
WE'RE ALIEUD TO DO IS TAKE
ADMINISTRATIVE ACTIONS ON
ADMINISTRATIVE SUPPLEMENTS,
BUDGET RESTORATIONS, AT LEAST
BELOW A REASONABLE THRESHOLD, IF
THEY WERE HUGE WORKERS WOULD BE
COMING TO YOU, BRIDGE FUNDING,
CHANGE OF PI OR INSTITUTION, ALL
OF THESE THINGS ARE BUSINESS WE
CAN ACCOMPLISH WITHOUT COMING TO
YOU FOR APRAWFAL OR ADVICE, WE
USE SPECIFIC PROFESSIONAL
SERVICES OF NOT MORE THAN A
HUNDRED PROFESSIONAL EXPERTS TO
BE APPOINTED BY DR. GIBBONS AND
WE OCCASIONALLY EXPEDITE COUNCIL
CONATURE KENS USING THE
PROCEDURES OUTLINES IN THE
DELEGATED AUTHORITIES DOCUMENT
WHICH YOU'VE SEEN IN THE
ELECTRONIC COUNCIL BOOK.
THESE ARE FOR THINGS LIKE
PROGRAM PLANTS AND BLOCKED
CONCURRENCE AND WE DO THOSE
THROUGH THE ELECTRONIC COUNCIL
BOOKS SOPHISTICATEDY YOU'VE ALL
BEEN ASKED TO PARTICIPATE THAT
WAY AND OCCASIONALLY WE HAVE TO
MAKE CERTAIN ADMINISTRATIVE
DECISIONS, REGARDING THE
SELECTION AND FUNDING OF
COMPETING GRANT APPLICATIONS MRI
KAIGDZS.
IN THE EVENT OF A FEDERALLY
DECLARED EMERGENCY.
SO THESE APPLY FOR THE
ELECTRONIC COUNCIL BOOK AND
THESE ARIFIES EEBL, AND YOU CAN
IMAGINE THERE MIGHT BE SOMETHING
THAT CREATES AN ISSUE AND WE
WOULD HAVE TO DO THAT SO WHAT I
WOULD LIKE TO KNOW IS DOES
ANYBODY HAVE ANY QUESTIONS OR
CONCERNS ABOUT THESE DELEGATED
AUTHORITIES?
ARE THERE ANY OBJECTIONS TO
PROCEEDING WITH THE DELEGATED
AUTHORITIES.
OKAY, WELL, HAVING SAID THAT AND
HAVING HEARD NO OBJECTIONS, WE
WILL CONSIDER THESE APPROVED FOR
YET ANOTHER YEAR, OH JOY.
THANK YOU VERY MUCH.
SO AT THIS POINT I WILL TURN IT
BACK OVER TO YOU IF YOU WANT TO
HAVE OPEN DISCUSSION AT OPEN
SESSION SO THAT THE PUBLIC COULD
HEAR ANY OF IT AND IF NOT, YOU
COULD ADJOURN THE MEETING, IT'S
UP TO YOU.
>> ANY OTHER FURTHER ISSUES OR
COMMENTS, YOU WOULD LIKE TO MAKE
IN OPEN SESSION?
I WILL BE HAPPY TO ENTERTAIN
THOSE AT THIS TIME BEFORE WE
ADJOURN.
THIS IS 1 OF THE CHALLENGES WITH
THE VIRTUAL MEETING IN THAT
USUALLY AT THE END OF COUNCIL
EVERYBODY'S RUNNING FOR THEIR
TAXIS AND AIRLINES AND SO WE DO
ACTUALLY HAVE A FEW MOMENTS HERE
IF THERE WERE SOME ISSUES OR
MATTERS OF CONCERN YOU WOULD
LIKE TO RAISE.
BUT HEARING NONE DR. MOEN.
>> MONICA HAS HER HAND UP.
>> GREAT.
THIS IS JUST A QUICK, I WANT TO
SAY IN CASE THIS IS MY LAST
COUNCIL, YOU NEVER KNOW, I JUST
WANT TO SAY THANK YOU.
IT'S BEEN AN HONOR AND A
PRIVILEGE TO SERVE AND HONESTLY
I'M ALWAYS AVAILABLE IF YOU NEED
ME AGAIN, IF THINGS DIDN'T QUITE
FINISH WITH THE NEW FOLKS COMING
ON BUT I'VE REALLY ENJOYED IT
AND TODAY WAS REALLY
PARTICULARLY A GREAT DAY, I
THINK THE TOPICS WERE
INCREDIBLY, POIGNANT AND
NECESSARY AND I REALLY LOVE THE
DIRECTION THAT NIH AND NHLBI ARE
GOING SO THANK YOU VERY MUCH.
>> THANK YOU, SO MUCH FOR THAT
DR. KRAFT.
AND AGAIN I DON'T WANT TO MAKE A
PREMATURE JUDGMENT, THAT WE WILL
NEVER NEED YOU BACK AGAIN,
CERTAINLY YOUR SERVICE HAS BEEN
EXEMPLARY AND WE APPRECIATE YOU
AS A FABULOUS RESOURCE FOR THE
PARTICULARLY THE PULL MONITORARY
COMMUNITY BUT THE ENTIRE NHLBI
COMMUNITY.
AS WE APPRECIATE YOUR LEADERSHIP
AND I PUT YOU TO WORK ALREADY ON
SOME OTHER THINGS SO,--
>> THAT'S ALL GOOD.
>> SO BUT AGAIN, WE APPRECIATE
THAT AND ALSO WANT TO EXTEND
THAT TO THE OTHER 5 MEMBERS OF
COUNCIL WHO SQUEEZED IN ANOTHER
SESSION AND AGAIN WE'RE HOPEFUL
THAT CONGRESS IN DOWN TOWN WILL
BE EFFICIENT AND EFFECTIVE AND
WE WILL HAVE A BUDGET AND A NEW
SLATE, BUT HOPE SPRINGS ETERNAL
IN WASHINGTON D. C. THAT THE
BUREAUCRACY WILL TURN.
WE LOOK FORWARD TO SEEING YOU
ALL IN JUNE, ALONG WITH THE NEW
SLATE.
SO DR. MOEN, I WILL TURN IT BACK
TO YOU.
WE WILL CALL THE 296th MEETING
OF THE NATIONAL HEART, LUNG
BLOOD ADVISORY COUNCIL
ADJOURNED.
>> THANK YOU DR. GIBBONS.
THANK YOU ALL FOR COMING TODAY,
I'M DPLAD WE DIDN'T HAVE TO TAKE
UP YOUR ENTIRE DAY AND IT WAS
GREAT TO SEE EVERYBODY EVEN
THOUGH IT WAS VIRTUAL.
I WILL JUST REMIND YOU, PLEASE
DO TAKE A LOOK AT THE FUTURE
COUNCIL DATES SO THAT YOU DON'T
MISS THE EXPWIEWN MEETING.
WE DON'T WANT YOU TO MISS THE
JUNE MEETINGS SO WE'LL SEE YOU
THERE AND THANKS EVERYBODY FOR
ALL THE WORK YOU DO TO HELP KEEP
US ON TRACK.
WE'RE HAPPY TO HEAR FROM YOU.
ANYTIME.
WE'RE DONE.