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GOOD AFTERNOON,
EVERYONE.

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THANK YOU SO MUCH FOR TUNING IN.

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00:00:08,161 --> 00:00:11,164
I THINK WE ALMOST HAVE ALL OF

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OUR MEMBERS HERE.

5
00:00:12,466 --> 00:00:16,169
SO I'M GOING TO GIVE IT -- WE'RE

6
00:00:16,169 --> 00:00:17,671
ALREADY AFTER NOON SO WE'LL GET

7
00:00:17,671 --> 00:00:18,905
STARTED.

8
00:00:18,905 --> 00:00:20,874
THANK YOU SO MUCH EVERYONE FOR

9
00:00:20,874 --> 00:00:22,943
TUNING IN TODAY.

10
00:00:22,943 --> 00:00:26,379
IT IS MY PLEASURE TO WELCOME

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YOU.

12
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A VERY WARM WELCOME TO THE

13
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86th MEETING OF THE ADVOCATES.

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WE'RE SO GRATEFUL FOR YOUR TIME

15
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AND EXPERTISE AND APPRECIATE ALL

16
00:00:38,725 --> 00:00:41,528
THAT YOU DO BEHALF OF PATIENTS

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ACROSS THE UNITED STATES.

18
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SO I WILL TURN IT OVER TO OUR

19
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FEARLESS CHAIR ANJEE DAVIS TO

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00:00:47,567 --> 00:00:50,804
GET US STARTED BUT I WANTED TO

21
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FORECAST FOR YOU WHAT WE'RE

22
00:00:52,806 --> 00:00:54,241
GOING TO DO.

23
00:00:54,241 --> 00:00:56,143
WE HAVE A TERRIFIC MEETING

24
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PLANNED FOR YOU.

25
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AS PER THE USUAL WE'LL HAVE A

26
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DIRECTOR'S REPORT FROM OUR

27
00:01:03,150 --> 00:01:07,053
ACTING DIRECTOR DR. DOUGLAS

28
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LOWY.

29
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AN UPDATE AS USUAL AND THEN

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JOINED BY DR. PHIL CASTLE WHO'S

31
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THE DIRECTOR OF NIH'S DIVISION

32
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OF CANCER PREVENTION AND TALKING

33
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ABOUT CANCER PREVENTION

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RESEARCH.

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AND FINALLY OUR LAST SEGMENT OF

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OUR MEETING TODAY IS SORT OF

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PART OF A SERIES THAT WE STARTED

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AT THE LAST MEETING WHICH IS

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AROUND EXCEPTIONAL EXAMPLES OF

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RESEARCH ADVOCACY IN THE

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COMMUNITY WHERE WE HIGHLIGHT

42
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PROGRAMS THAT ARE BRINGING IN

43
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RESEARCH ADVOCATES AND WE WILL

44
00:01:43,089 --> 00:01:46,059
BE TALKING ABOUT THE PIVOT

45
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PROGRAM AT THE UNIVERSITY OF

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KANSAS.

47
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SO THAT WILL BE A PANEL

48
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DISCUSSION WITH ADVOCATE.

49
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SOME OF THE STAFF AT THE

50
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UNIVERSITY OF KANSAS AS WELL AS

51
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SOME OF OUR NCI PROGRAM STAFF

52
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WHO HELPED ADMINISTER THAT

53
00:02:01,374 --> 00:02:02,842
INITIATIVE SO WITH THAT I WANT

54
00:02:02,842 --> 00:02:05,145
TO AGAIN THANK YOU FOR YOUR TIME

55
00:02:05,145 --> 00:02:06,846
TODAY.

56
00:02:06,846 --> 00:02:08,882
I KNOW THAT WE HAVE LOTS OF

57
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DIFFERENT FOLKS THAT WORK ACROSS

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CANCER RESEARCH BUT ADVOCATES

59
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WEAR MANY HATS AND WE'RE JUST

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BUT ONE PIECE OF THE ADVOCACY

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PIE.

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THAT MAKES YOUR TIME MORE VALUED

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AND I APPRECIATE YOU SPENDING

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THE TIME WITH US THIS AFTERNOON.

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ANJEE I THINK YOU'RE HERE AND

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READY TO GO SO WITH THAT I'LL

67
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TURN IT OVER TO YOU TO GET US

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STARTED.

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>> GREAT.

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GOOD MORNING, EVERYBODY.

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I'M GOING TO START WITH OUR

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HOUSEKEEPING STATEMENTS SO OUR

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OPENING STATEMENTS.

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AS COMMITTEE MEMBERS I WANT TO

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REMIND YOU THAT YOU MUST ABSENT

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YOURSELF DURING SPECIFIC

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DISCUSSIONS WHEN YOUR

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PARTICIPATION AND DID I LOBE

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RACIALS ON A PARTICULAR PRODUCT,

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PROGRAM OR OTHER SPECIFIC MATTER

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WOULD CONSTITUTE A CONFLICT OF

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INTEREST OR THE APPEARANCE OF

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ONE.

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ADD ADVICE THE EXECUTIVE

85
00:03:06,072 --> 00:03:09,709
SECRETARY REGARDING THAT MATTER.

86
00:03:09,709 --> 00:03:11,478
GOVERNING CONFLICT OF INTEREST

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BASED ON FINANCIAL HOLDINGS OF

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SPECIFIC SPECIAL GOVERNMENT

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EMPLOYEES WHICH INCLUDES ALL

90
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MEMBERS OF THIS COMMITTEE WE

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00:03:17,784 --> 00:03:20,287
MUST DEPEND ON YOU TO

92
00:03:20,287 --> 00:03:22,622
VOLUNTARILY ABSENT YOURSELF

93
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DURING ANY AND OTHER DISCUSSIONS

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THAT COULD IMPACT THE STATUS OF

95
00:03:26,526 --> 00:03:28,295
THE HOLDINGS.

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WE TRUST YOUR JUDGMENTS IN THESE

97
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INSTANCES.

98
00:03:31,998 --> 00:03:34,801
A QUORUM IS REQUIRED IN WHICH A

99
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VOTE OCCURS.

100
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A MINIMUM OF SIX APPOINTED

101
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EMERGENCIES MUST BE PRESENT TO

102
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VOICE YOUR VOTES.

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NEW MEMBERS WHO ARE NOT CURRENT

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MEMBERS ARE NOT VOTING UNTIL

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THEY'VE BEEN CLEARED.

106
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OUR PUBLIC COMMENT STATEMENT IS

107
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MEMBERS OF THE PUBLIC CAN WISH

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TO EXPRESS VIEWS REGARDING ANY

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ITEMS DISCUSSED DURING THE

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MEETING MAY DO SO BY WRITING MSS

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MEETING AND WRITTEN STATEMENTS

112
00:04:09,202 --> 00:04:10,904
BY MEMBERS OF THE PUBLIC WILL

113
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RECEIVE CAREFUL CONSIDERATION.

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THANKS FOR BEARING WITH ME AS I

115
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READ THESE TO YOU BUT I WANT TO

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WELCOME EVERYBODY.

117
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THIS IS THE LAST MEETING I WILL

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BE CHAIRING WHICH HAS GONE BY

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REALLY FAST.

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I WANT TO SAY A FEW THINGS

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BEFORE WE GET STARTED TODAY AND

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I WANT TO THANK AMY, PATRICK AND

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VINCENT FOR THE WORK THAT

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THEY'VE DONE BEHIND THE SCENES

125
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AND THEIR PATIENCE WITH ME

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TRYING TO FIGURE OUT I THINK HOW

127
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TO PULL THESE AGENDAS TOGETHER.

128
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TOOK A YEAR VIRTUALLY BUT WE GOT

129
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THERE.

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AND THEY'VE BEEN SO DILIGENT IN

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PREPARING THESE AGENDAS AND

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SPEAKERS FOR US.

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NO MATTER HOW DIFFICULT THE

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CHALLENGES WERE.

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THEY WERE ALWAYS WORKING BEHIND

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THE SCENES TO MAKE IT HAPPEN FOR

137
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THIS COMMITTEE.

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I WANT TO GIVE MY HEARTFELT

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THANKS FOR THEM FOR THE HARD

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WORK OVER THE LAST TWO TERMS.

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AND THEN I JUST WANT TO SAY

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THANK YOU FOR YOUR PATIENCE.

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YOU'VE BEEN AMAZING TO WORK

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WITH.

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AND VERY PATIENT AND ENGAGED AND

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I WANT TO SAY THAT WESTE -- WHES

147
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INVITED I HAD JUST BEEN

148
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DIAGNOSED WITH CANCER AND I

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LEAVE THIS POSITION -- MY MOM

150
00:05:32,252 --> 00:05:33,586
WAS DIAGNOSED WITH LUNG CANCER.

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WE THINK ABOUT THESE COMMITTEES.

152
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WE THINK ABOUT WHERE WE SIT AND

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THEY ARE PART OF OUR JOBS BUT

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TRULY IT IS AN AD VOTE CAR SEE

155
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ROLE AND OUR ROLE AND VOICE IN

156
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WHAT WE'RE SEEING DURING THIS

157
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CALLS IS TO DRIVE URGENCY AND

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PERSPECTIVE AND IN THIS

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PARTICULAR COMMITTEE IT'S ABOVE

160
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THE CLINICAL TRIALS -- TACTICAL

161
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EFFORT AND STRATEGIC GOALS OF

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NCI.

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AGAIN JUST COMMEND THE

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LEADERSHIP OF THIS GROUP.

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SO PROUD TO BE PART OF IT AND

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LOOK FORWARD TO SEEING WHAT WE

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DO TODAY AND TODAY I WAS ABLE TO

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-- AT MY LAST MEETING WAS GOING

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TO BE ABOUT -- AND ABOUT EX'EM N

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ADVOCACY.

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AS WE THINK ABOUT WHAT WE CAN

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ADVICE THIS GROUP AND PROVIDE

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PERSPECTIVE THIS IS A PIVOTAL

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TIME FOR THIS COMMITTEE.

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SO I TURN IT OVER TO DR. DOUG

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LOWY.

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INVITE HIM TO DELIVER HIS

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UPDATES.

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LOOK FORWARD TO HEARING FROM

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HIM.

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HE HAS HAD A FULL PLATE DURING

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THIS TRANS SICKS

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>> ANJEE, GOOD MORNING TO
YOU

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AND GOOD AFTERNOON TO EVERYONE

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WHO'S IN THE EASTERN TIME ZONE

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AND GOOD MORNING TO THOSE OF YOU

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WHO ARE WEST OF THE EASTERN TIME

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ZONE.

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I'M DELIGHTED TO BE ABLE TO TALK

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WITH YOU TODAY AND MY REMARKS

191
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WILL LEAVE ENOUGH TIME SO THAT

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THERE SHOULD BE ADEQUATE TIME

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FOR QUESTIONS AND COMMENTS WHEN

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THEY ARE FINISHED.

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IT'S BEEN THREE YEARS SINCE THE

196
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LAST TIME I WAS ACTING DIRECTOR

197
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OF NCI.

198
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AND THERE HAS BEEN A LOT OF TURN

199
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OVER IN THE NCRA.

200
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SO I'M GOING TO SPEND A FEW

201
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MINUTES REINTRODUCING MYSELF AND

202
00:07:37,477 --> 00:07:42,982
MY PERSPECTIVE AS NCI DIRECTOR.

203
00:07:42,982 --> 00:07:45,652
BUT BEFORE WE GO THERE I WOULD

204
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LIKE TO HAVE THE NEXT SLIDE AND

205
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IT REALLY IS A THANK YOU SLIDE

206
00:07:54,727 --> 00:07:57,564
TO ANJEE DAVIS AND ANJEE IT IS

207
00:07:57,564 --> 00:08:02,135
REALLY AMAZING HOW CANCER IS

208
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AFFECTING YOU DIRECTLY AND YOUR

209
00:08:03,536 --> 00:08:07,307
FAMILY THROUGHOUT THIS PERIOD

210
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AND I HOPE THAT EVERYONE WILL DO

211
00:08:11,744 --> 00:08:11,945
WELL.

212
00:08:11,945 --> 00:08:14,847
THANK YOU SO MUCH FOR YOUR

213
00:08:14,847 --> 00:08:18,017
LEADERSHIP ON THE NCRA AND YOUR

214
00:08:18,017 --> 00:08:21,888
REMARKS WERE SPOT ON.

215
00:08:21,888 --> 00:08:25,058
JENNIFER PEGHER IS GOING TO BE

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00:08:25,058 --> 00:08:27,293
CYCLING OFF OF NCRA BUT ALTHOUGH

217
00:08:27,293 --> 00:08:31,364
SHE CAN RUN AS MOHAMMED ALI SAID

218
00:08:31,364 --> 00:08:32,498
SHE CANNOT HIDE AND I'M GOING TO

219
00:08:32,498 --> 00:08:34,934
BE AT THE AACI MEETING IN

220
00:08:34,934 --> 00:08:37,503
OCTOBER AND I LOOK FORWARD TO

221
00:08:37,503 --> 00:08:39,806
SEEING JENNIFER THERE.

222
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AND I WOULD BE REMISS IF I WERE

223
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NOT ALSO GOING TO WELCOME ANNIE

224
00:08:45,311 --> 00:08:48,815
ELLIS WHO WILL BE THE INCOMING

225
00:08:48,815 --> 00:08:53,052
CHAIR OF NCRA AND LOOK FORWARD

226
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TO BEING ABLE TO WORK TOGETHER

227
00:08:55,088 --> 00:08:56,489
WITH YOU.

228
00:08:56,489 --> 00:08:59,125
BEFORE I GO ON TO THE NEXT SLIDE

229
00:08:59,125 --> 00:09:02,328
HOWEVER, I WOULD LIKE TO GIVE A

230
00:09:02,328 --> 00:09:05,431
SHOUT OUT TO MELINDA WHO'S A

231
00:09:05,431 --> 00:09:11,104
MEMBER OF NCRA AND ON-LINE TODAY

232
00:09:11,104 --> 00:09:12,805
SHE AND I HAVE KNOWN EACH OTHER

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00:09:12,805 --> 00:09:14,374
FOR QUITE A WHILE AND SHE HAS

234
00:09:14,374 --> 00:09:20,246
BEEN AN AMAZING ADVOCATE FOR

235
00:09:20,246 --> 00:09:22,949
CANCER RESEARCH AND MELINDA I

236
00:09:22,949 --> 00:09:25,118
HOPE YOU'RE CONTINUING TO DO

237
00:09:25,118 --> 00:09:28,054
WELL AND I LOOK FORWARD TO

238
00:09:28,054 --> 00:09:31,290
MEETING THE OTHER MEMBERS OF THE

239
00:09:31,290 --> 00:09:35,995
NCRA AS WE GO ALONG.

240
00:09:35,995 --> 00:09:39,432
I'M DIVIDED AND SHOWING ON THE

241
00:09:39,432 --> 00:09:41,367
NEXT SLIDE, I'M TRYING TO COVER

242
00:09:41,367 --> 00:09:46,372
A NUMBER OF DIFFERENT ISSUES.

243
00:09:46,372 --> 00:09:50,443
FIRST CONTINUITY OF NCI

244
00:09:50,443 --> 00:09:50,743
LEADERSHIP.

245
00:09:50,743 --> 00:09:53,346
A COUPLE OF SLIDES ABOUT THE NCI

246
00:09:53,346 --> 00:09:53,846
BUDGET.

247
00:09:53,846 --> 00:09:57,750
BUT AS ALREADY MENTIONED HOLLY

248
00:09:57,750 --> 00:10:00,386
GIBBONS IS GOING TO BE TALKING

249
00:10:00,386 --> 00:10:03,322
MORE IN DEPTH ABOUT THE BUDGET.

250
00:10:03,322 --> 00:10:05,892
AND GIVING YOU SOME RESEARCH

251
00:10:05,892 --> 00:10:09,462
UPDATES AND FINALLY TALKING

252
00:10:09,462 --> 00:10:11,197
ABOUT THE CANCER MOONSHOT.

253
00:10:11,197 --> 00:10:14,767
AND YOU WILL BE HEARING AS

254
00:10:14,767 --> 00:10:17,170
MENTIONED FROM PHIL CASTLE AND

255
00:10:17,170 --> 00:10:18,705
ONE OF THE AREAS THAT HE WILL BE

256
00:10:18,705 --> 00:10:21,340
TALKING ABOUT IS MULTI-CANCER

257
00:10:21,340 --> 00:10:24,977
DETECTION TESTS WHICH REALLY WE

258
00:10:24,977 --> 00:10:27,547
ENVISION BEING PART OF THE NEW

259
00:10:27,547 --> 00:10:29,749
MOONSHOT BUT WE ARE TRYING TO

260
00:10:29,749 --> 00:10:33,052
GET STARTED BY DOING IT ALREADY

261
00:10:33,052 --> 00:10:34,787
IN FY23.

262
00:10:34,787 --> 00:10:36,489
IF I COULD HAVE THE NEXT SLIDE

263
00:10:36,489 --> 00:10:40,593
-- THIS BASICALLY TELLS YOU

264
00:10:40,593 --> 00:10:46,466
ABOUT THE NCI DIRECTOR'S HAROLD

265
00:10:46,466 --> 00:10:49,102
VARNESS WAS THE DIRECTOR.

266
00:10:49,102 --> 00:10:53,473
NED SHARPLESS WHO YOU'VE MET AND

267
00:10:53,473 --> 00:10:55,708
HEARD FROM HAS BEEN THE LEADER

268
00:10:55,708 --> 00:10:58,411
UP UNTIL TWO MONTHS AGO.

269
00:10:58,411 --> 00:11:00,813
TODAY MARKS THE END OF MY SECOND

270
00:11:00,813 --> 00:11:02,648
MONTH AS ACTING DIRECTOR.

271
00:11:02,648 --> 00:11:06,419
AND AS YOU MAY SEE THAT THIS IS

272
00:11:06,419 --> 00:11:10,089
ACTUALLY MY THIRD ONCE IN A

273
00:11:10,089 --> 00:11:12,325
LIFETIME OPPORTUNITY TO BE THE

274
00:11:12,325 --> 00:11:15,962
ACTING DIRECTOR OF NCI.

275
00:11:15,962 --> 00:11:18,598
IF WE COULD DO THE NEXT SLIDE --

276
00:11:18,598 --> 00:11:23,035
I'VE BEEN THE DEPUTY DIRECTOR AT

277
00:11:23,035 --> 00:11:26,405
NCI SINCE 2010.

278
00:11:26,405 --> 00:11:29,408
AND ALTHOUGH THE DIRECTOR IS AN

279
00:11:29,408 --> 00:11:31,077
IMPORTANT POSITION IT'S REALLY

280
00:11:31,077 --> 00:11:35,248
ALSO IMPORTANT TO RECOGNIZE THAT

281
00:11:35,248 --> 00:11:38,551
NCI LEADERSHIP IS FAR MORE THAN

282
00:11:38,551 --> 00:11:40,653
THE DIRECTOR AND THIS JUST GIVES

283
00:11:40,653 --> 00:11:45,324
US A PARTIAL LIST OF PEOPLE WHO

284
00:11:45,324 --> 00:11:47,493
ARE IN LEADERSHIP POSITIONS AT

285
00:11:47,493 --> 00:11:48,728
NCI.

286
00:11:48,728 --> 00:11:52,698
BUT AS YOU ARE AWARE AND YOU'LL

287
00:11:52,698 --> 00:11:56,202
CERTAINLY BE HEARING FROM PHIL

288
00:11:56,202 --> 00:11:57,837
EVEN PEOPLES NAMES WHO ARE NOT

289
00:11:57,837 --> 00:11:59,705
ON THE LIST ARE CRITICALLY

290
00:11:59,705 --> 00:12:02,642
IMPORTANT TO THE PROGRESS THAT

291
00:12:02,642 --> 00:12:06,212
WE MAKE IN CANCER RESEARCH.

292
00:12:06,212 --> 00:12:08,147
THROUGH NCI.

293
00:12:08,147 --> 00:12:10,750
NEXT SLIDE.

294
00:12:10,750 --> 00:12:16,923
THIS SLIDE GOES OVER SOME OF THN

295
00:12:16,923 --> 00:12:18,825
INVOLVED OVER THE LAST FEW

296
00:12:18,825 --> 00:12:19,358
YEARS.

297
00:12:19,358 --> 00:12:22,128
AND I WANT YOU TO TRY TO THINK

298
00:12:22,128 --> 00:12:27,934
ABOUT THEM IN THE CONTEXT OF MY

299
00:12:27,934 --> 00:12:31,237
BEING IN BETWEEN DIFFERENT

300
00:12:31,237 --> 00:12:31,504
DIRECTORS.

301
00:12:31,504 --> 00:12:34,106
SO FOR EXAMPLE IN 2015 THE

302
00:12:34,106 --> 00:12:35,808
PRECISION MEDICINE INITIATIVE IN

303
00:12:35,808 --> 00:12:38,077
ONCOLOGY WAS ANNOUNCED IN

304
00:12:38,077 --> 00:12:40,780
JANUARY OF 2015 BY THEN

305
00:12:40,780 --> 00:12:41,714
PRESIDENT OBAMA.

306
00:12:41,714 --> 00:12:49,288
AND HAROLD VAR NUE WAS THE

307
00:12:49,288 --> 00:12:49,956
DIRECTOR AT THE TIME.

308
00:12:49,956 --> 00:12:52,225
BUT THE IMPLEMENTATION OF THE

309
00:12:52,225 --> 00:12:53,926
INITIATIVE WAS REALLY SOMETHING

310
00:12:53,926 --> 00:12:56,195
THAT I WAS INVOLVED IN AND SO IT

311
00:12:56,195 --> 00:12:59,732
WAS VERY IMPORTANT THAT THERE BE

312
00:12:59,732 --> 00:13:03,135
CONTINUITY AND ONE OF THE KEY

313
00:13:03,135 --> 00:13:04,637
INITIATIVES OF THE PRECISION

314
00:13:04,637 --> 00:13:06,939
MEDICINE INITIATIVE WAS THE

315
00:13:06,939 --> 00:13:08,641
MATCH TRIAL WHICH MANY OF YOU

316
00:13:08,641 --> 00:13:10,943
HAVE HEARD ABOUT AND IT REALLY

317
00:13:10,943 --> 00:13:12,445
WAS A PATH BREAKING TRIAL

318
00:13:12,445 --> 00:13:16,015
BECAUSE IT WAS FOCUSED ON

319
00:13:16,015 --> 00:13:18,551
MOLECULAR ABNORMALITIES AND THE

320
00:13:18,551 --> 00:13:20,786
FASTEST APPROVING TRIAL THAT NCI

321
00:13:20,786 --> 00:13:22,054
HAS HAD.

322
00:13:22,054 --> 00:13:26,959
AGAIN IN 2015 WE INITIATED THE

323
00:13:26,959 --> 00:13:29,562
NATIONAL CRY OH ELECTRON GRAPH

324
00:13:29,562 --> 00:13:30,696
USER FACILITY.

325
00:13:30,696 --> 00:13:33,599
AND THIS WAS SOMETHING THAT

326
00:13:33,599 --> 00:13:35,668
HEROLD DURING THE LAST TWO OR

327
00:13:35,668 --> 00:13:38,304
THREE YEARS AS NCI DIRECTOR HAD

328
00:13:38,304 --> 00:13:39,739
THOUGHT ABOUT BUT THE ACTUAL

329
00:13:39,739 --> 00:13:47,613
DECISION TO DO THIS AT FREDERICK

330
00:13:47,613 --> 00:13:50,082
WAS MADE BY ME WHEN I WAS ACTING

331
00:13:50,082 --> 00:13:52,451
DIRECTOR AND IT'S BEEN AMAZINGLY

332
00:13:52,451 --> 00:13:53,653
SUCCESSFUL.

333
00:13:53,653 --> 00:13:55,821
THERE HAVE BEEN MORE THAN 500

334
00:13:55,821 --> 00:13:56,756
STRUCTURES THAT HAVE BEEN

335
00:13:56,756 --> 00:13:59,625
IDENTIFIED SINCE IT WAS REALLY

336
00:13:59,625 --> 00:14:03,696
STOOD UP STARTING IN 2017.

337
00:14:03,696 --> 00:14:08,434
BUT IN 20169 CANCER MOONSHOT THE

338
00:14:08,434 --> 00:14:11,470
FIRST PHASE INITIATED BY THEN

339
00:14:11,470 --> 00:14:15,207
VICE PRESIDENT BIDEN AND I WAS

340
00:14:15,207 --> 00:14:18,110
THE ACTING DIRECTOR AND THEN

341
00:14:18,110 --> 00:14:22,882
STARTING IN 2016 ANOTHER ISSUE

342
00:14:22,882 --> 00:14:26,385
THAT HEROLD VARS IN DEALT WITH

343
00:14:26,385 --> 00:14:28,321
WAS TO DO WITH THE SUPPORT

344
00:14:28,321 --> 00:14:30,656
GRANTS FOR THE CANCER CENTERS SO

345
00:14:30,656 --> 00:14:32,725
THE DECISION WAS MADE TO

346
00:14:32,725 --> 00:14:35,161
SUBSTANTIALLY INCREASE THE

347
00:14:35,161 --> 00:14:37,163
SUPPORT FOR THEM AND YOU WILL BE

348
00:14:37,163 --> 00:14:44,637
HEARING LATER TODAY FROM THE

349
00:14:44,637 --> 00:14:45,538
KANSAS UNIVERSITY CENTER.

350
00:14:45,538 --> 00:14:46,906
THEY HAVE JUST GONE THROUGH

351
00:14:46,906 --> 00:14:50,109
THEIR RENEWAL AND HAVE DONE

352
00:14:50,109 --> 00:14:52,945
SPECTACULARLY WELL.

353
00:14:52,945 --> 00:14:55,014
AND THEN IN 2019 DURING THE

354
00:14:55,014 --> 00:14:58,684
SEVEN MONTHS I WAS ACTING

355
00:14:58,684 --> 00:15:01,220
DIRECTORRED IN SHARPLESS HAD

356
00:15:01,220 --> 00:15:04,857
IDENTIFIED THE ISSUE OF THERE

357
00:15:04,857 --> 00:15:06,959
BEING A PREFERENTIAL INCREASE IN

358
00:15:06,959 --> 00:15:09,195
THE NUMBER OF GRANT APPLICATIONS

359
00:15:09,195 --> 00:15:14,800
TO NCI COMPARED WITH THE REST OF

360
00:15:14,800 --> 00:15:16,135
THE NIH.

361
00:15:16,135 --> 00:15:19,972
AND AS A CONSEQUENCE OUR LEVELS

362
00:15:19,972 --> 00:15:23,075
OF SUCCESS AND OUR SO-CALLED PAY

363
00:15:23,075 --> 00:15:25,578
LINES WERE GOING DOWN.

364
00:15:25,578 --> 00:15:27,580
BUT HE HAD NOT HAD AN

365
00:15:27,580 --> 00:15:29,215
OPPORTUNITY YET TO BRING THIS TO

366
00:15:29,215 --> 00:15:32,318
THE A ATTENTION OF CONGRESS AND

367
00:15:32,318 --> 00:15:41,594
I WAS ABLE TO PROVIDE THAT

368
00:15:41,594 --> 00:15:43,562
CONTINUITY IN 2019 AND THIS HAS

369
00:15:43,562 --> 00:15:46,599
LED TO CONS, RECOGNITION ABOUT

370
00:15:46,599 --> 00:15:48,401
THE IMPORTANCE OF OUR PAY LINE

371
00:15:48,401 --> 00:15:51,537
AND SUCCESS RATES FOR FIRST TIME

372
00:15:51,537 --> 00:15:56,976
IN TRYING TO BE AS SUCCESSFUL AS

373
00:15:56,976 --> 00:15:58,444
POSSIBLE THERE.

374
00:15:58,444 --> 00:16:02,281
SO WHAT ABOUT -- THE NEXT SLIDE

375
00:16:02,281 --> 00:16:06,285
TALKS ABOUT THREE CURRENT

376
00:16:06,285 --> 00:16:06,585
INITIATIVES.

377
00:16:06,585 --> 00:16:09,422
ONE IS THE CANCER MOONSHOT.

378
00:16:09,422 --> 00:16:12,425
AND I WILL BE TALKING ABOUT THAT

379
00:16:12,425 --> 00:16:17,863
IN A FEW MINUTES AND IN A LITTLE

380
00:16:17,863 --> 00:16:19,265
BIT OF DETAIL.

381
00:16:19,265 --> 00:16:21,834
BUT THE CANCER CENTERS -- ABOUT

382
00:16:21,834 --> 00:16:23,702
THREE QUARTERS OF THE RESEARCH

383
00:16:23,702 --> 00:16:29,708
THAT THE FUNDING THAT WE  --

384
00:16:29,708 --> 00:16:31,644
SUPPORT FOR EXTRAMURAL ACTIVITY

385
00:16:31,644 --> 00:16:34,847
IS ACTUALLY CONDUCTED AT THE NCI

386
00:16:34,847 --> 00:16:36,582
DESIGNATED CANCER CENTERS.

387
00:16:36,582 --> 00:16:39,185
SO WE HAVE FINISHED THE FIRST

388
00:16:39,185 --> 00:16:42,021
TWO PHASES OF THE SUPPORT GRANTS

389
00:16:42,021 --> 00:16:43,856
AND SO WE'RE IN THE PROCESS OF

390
00:16:43,856 --> 00:16:46,859
MAKING DECISIONS ABOUT GOING

391
00:16:46,859 --> 00:16:49,695
FORWARD FOR THE NEXT PHASE AND

392
00:16:49,695 --> 00:16:52,865
THEN THE THIRD -- THE FREDERICK

393
00:16:52,865 --> 00:16:56,135
NATIONAL LAB HAS FOR LAST

394
00:16:56,135 --> 00:16:58,871
SEVERAL YEARS HAVE HAD THE

395
00:16:58,871 --> 00:17:00,272
INITIATIVE WHICH SOME OF YOU

396
00:17:00,272 --> 00:17:02,074
HAVE HEARD A I'LL MENTION ABOUT

397
00:17:02,074 --> 00:17:04,610
IN PASSING IN A FEW MORE SLIDES.

398
00:17:04,610 --> 00:17:06,645
THAT INITIATIVE HAS BEEN VERY

399
00:17:06,645 --> 00:17:08,914
SUCCESSFUL AND WE'RE TRYING TO

400
00:17:08,914 --> 00:17:13,352
THINK ABOUT WHAT ADDITIONAL

401
00:17:13,352 --> 00:17:15,921
SIGNATURE INITIATIVES CAN BE

402
00:17:15,921 --> 00:17:18,057
DEVELOPED.

403
00:17:18,057 --> 00:17:20,926
THE NEXT SLIDE SUMMARIZES SOME

404
00:17:20,926 --> 00:17:24,497
OF THE RECENT ACTIVITIES, THE

405
00:17:24,497 --> 00:17:26,365
AMERICAN ASSOCIATION FOR CANCER

406
00:17:26,365 --> 00:17:28,601
RESEARCH MEETING ACTUALLY TOOK

407
00:17:28,601 --> 00:17:32,338
PLACE BEFORE I BECAME ACTING

408
00:17:32,338 --> 00:17:35,908
DIRECTOR SOD IN AND I DID A

409
00:17:35,908 --> 00:17:37,376
TANDEM PRESENTATION -- BECAUSE

410
00:17:37,376 --> 00:17:41,280
THAT IS WHAT AACR ASKED FOR. 

411
00:17:41,280 --> 00:17:43,916
AND THEN I TALKED WITH THE

412
00:17:43,916 --> 00:17:46,719
NATIONAL ASSOCIATION OF CANCER

413
00:17:46,719 --> 00:17:48,120
CENTER DEVELOPMENT OFFICERS AND

414
00:17:48,120 --> 00:17:50,890
PUBLIC AFFAIRS AND MARKETING

415
00:17:50,890 --> 00:17:52,725
NETWORK GROUP AGAIN SHORTLY

416
00:17:52,725 --> 00:17:55,828
BEFORE I BECAME ACTING DIRECTOR

417
00:17:55,828 --> 00:17:57,630
ON APRIL 30th.

418
00:17:57,630 --> 00:18:03,369
AND THEN I TALKED AT -- AND MET

419
00:18:03,369 --> 00:18:06,038
WITH THE BOARD OF DIRECTORS AND

420
00:18:06,038 --> 00:18:09,642
I WILL BE TALKING TO THE AACI

421
00:18:09,642 --> 00:18:12,211
MEETING IN OCTOBER.

422
00:18:12,211 --> 00:18:14,947
SO I'M NOT THE ONLY PERSON WHO

423
00:18:14,947 --> 00:18:17,483
HAS BEEN NEWLY APPOINTED.

424
00:18:17,483 --> 00:18:19,385
AND THE NEXT SLIDE TELLS YOU

425
00:18:19,385 --> 00:18:22,087
ABOUT TWO CRITICAL NEW

426
00:18:22,087 --> 00:18:24,557
APPOINTMENTS.

427
00:18:24,557 --> 00:18:30,429
FIRST ON THE RIGHT -- BR IgA

428
00:18:30,429 --> 00:18:37,069
TTA -- WITTMAN AND DR. WEED MAN

429
00:18:37,069 --> 00:18:40,406
LEADS THE ONCOLOGY BRANCH BUT

430
00:18:40,406 --> 00:18:44,643
SHE IS WIDELY RECOGNIZED AS A

431
00:18:44,643 --> 00:18:50,683
LEA-- ALEADER IN PEDIATRIC CANC.

432
00:18:50,683 --> 00:18:53,852
AND RECEIVED FDA APPROVAL FOR

433
00:18:53,852 --> 00:18:56,155
CHILDREN WITH SEVERE NEURO

434
00:18:56,155 --> 00:18:57,923
FIBROS TO US.

435
00:18:57,923 --> 00:19:03,696
AND * AND GREG REAMAN WE'RE

436
00:19:03,696 --> 00:19:05,564
PRIVILEGED FOR HIM BE TO BE

437
00:19:05,564 --> 00:19:06,966
COMING TO NCI.

438
00:19:06,966 --> 00:19:11,136
HE IS A LONG TIME CANCER

439
00:19:11,136 --> 00:19:13,072
CHILDHOOD RESEARCHER WHO HAS

440
00:19:13,072 --> 00:19:16,342
BEEN AT THE FDA.

441
00:19:16,342 --> 00:19:20,512
AND HE WILL BE ACTUALLY STARTING

442
00:19:20,512 --> 00:19:23,349
IN SEPTEMBER AS THE SCIENTIFIC

443
00:19:23,349 --> 00:19:25,884
DIRECTOR FOR THE CHILDHOOD

444
00:19:25,884 --> 00:19:27,620
CANCER DATA INITIATIVE.

445
00:19:27,620 --> 00:19:30,422
ALTHOUGH HE IS NOT STARTING

446
00:19:30,422 --> 00:19:31,490
OFFICIALLY UNTIL SEPTEMBER HE

447
00:19:31,490 --> 00:19:34,059
WAS AT THE MEETING THAT WE HAD

448
00:19:34,059 --> 00:19:37,429
LAST WEEK OF THE CCDI MEETING

449
00:19:37,429 --> 00:19:40,566
AND HE WILL BE PROVIDE VERY

450
00:19:40,566 --> 00:19:42,635
IMPORTANT LEADERSHIP.

451
00:19:42,635 --> 00:19:47,273
THE NEXT SLIDE TALKS ABOUT THE

452
00:19:47,273 --> 00:19:49,675
OVERRIDING IMPORTANCE OF EQUITY

453
00:19:49,675 --> 00:19:54,780
AND JUST ONE ACTIVITY THAT I

454
00:19:54,780 --> 00:19:58,550
HAVE BEEN INVOLVED IN LAST MONTH

455
00:19:58,550 --> 00:20:01,253
-- AT THE BEGINNING OF THIS

456
00:20:01,253 --> 00:20:03,389
MONTH I SHOULD SAY TO RECOGNIZE

457
00:20:03,389 --> 00:20:07,459
JUNETEENTH AND I WAS JOINED BY

458
00:20:07,459 --> 00:20:10,929
DR. PAULETTE GRAY FROM NCI AND

459
00:20:10,929 --> 00:20:14,967
SHE HAS BEEN THE CO-DIRECTOR

460
00:20:14,967 --> 00:20:18,837
WITH --ED IN AND THE ECONOMIC

461
00:20:18,837 --> 00:20:21,407
COMMITTEE AND I'M NOW THE

462
00:20:21,407 --> 00:20:24,076
CO-DIRECTOR WITH PAULETTE OF

463
00:20:24,076 --> 00:20:24,677
THAT.

464
00:20:24,677 --> 00:20:29,148
AND NIH JUST HAD A TOWN HALL

465
00:20:29,148 --> 00:20:33,619
MEETING THAT ENDED AN HOUR AGO

466
00:20:33,619 --> 00:20:40,192
ON EQUITY AND NCIS GOING TO HAVE

467
00:20:40,192 --> 00:20:43,729
ANALOGOUS MEETING NEXT MONTH.

468
00:20:43,729 --> 00:20:47,099
THE NEXT SLIDE TELLS YOU THAT ON

469
00:20:47,099 --> 00:20:51,170
MY 12th DAY AS ACTING DIRECTOR

470
00:20:51,170 --> 00:20:52,371
I HAD THE OPPORTUNITY TO

471
00:20:52,371 --> 00:20:53,672
PARTICIPATE IN THE HEARING OF

472
00:20:53,672 --> 00:20:56,875
THE HOUSE SUBCOMMITTEE ON

473
00:20:56,875 --> 00:21:01,613
APPROPRIATIONS FOR THE NIH.

474
00:21:01,613 --> 00:21:03,115
AND THE TWO QUOTES THAT ARE

475
00:21:03,115 --> 00:21:04,817
SHOWN ON THE RIGHT JUST TELLS

476
00:21:04,817 --> 00:21:10,022
YOU HOW CRITICAL AND BIPARTISAN

477
00:21:10,022 --> 00:21:11,957
THE SUPPORT IS FOR CANCER

478
00:21:11,957 --> 00:21:12,858
RESEARCH.

479
00:21:12,858 --> 00:21:18,597
AND THE PHOTOGRAPH ON THE BOTTOM

480
00:21:18,597 --> 00:21:22,668
LEFT IS AFTER THE HEARING CHAIR

481
00:21:22,668 --> 00:21:25,137
DELORE ROW AND RANKING MEMBER

482
00:21:25,137 --> 00:21:27,139
COLE CAME OVER TO TALK WITH ME

483
00:21:27,139 --> 00:21:28,507
BECAUSE I HAVE NOPE BOTH OF THEM

484
00:21:28,507 --> 00:21:30,709
FOR A WHILE AND THEY ARE BOTH

485
00:21:30,709 --> 00:21:35,948
STEADFAST SUPPORTERS OF NIH IN

486
00:21:35,948 --> 00:21:38,283
GENERAL AND NCI IN PARTICULAR

487
00:21:38,283 --> 00:21:39,818
AND I'LL HAVE SOMETHING TO SAY

488
00:21:39,818 --> 00:21:46,725
ABOUT THAT IN THE NEW SLIDE.

489
00:21:46,725 --> 00:21:49,962
 LET ME WALK YOU THROUGH IT

490
00:21:49,962 --> 00:21:52,898
BECAUSE WHAT IT TELLS YOU IS IN

491
00:21:52,898 --> 00:21:56,001
ORANGE OVER THE LAST FEW YEARS

492
00:21:56,001 --> 00:21:58,871
IS THE PRESIDENT'S BUDGET FOR

493
00:21:58,871 --> 00:22:00,339
EACH YEAR.

494
00:22:00,339 --> 00:22:05,344
AND THEN IN THE BLUE GREEN THAT

495
00:22:05,344 --> 00:22:09,648
IS WHAT WAS ENACTED BY CONGRESS

496
00:22:09,648 --> 00:22:12,951
AND IN EVERY YEAR THE ENACTED

497
00:22:12,951 --> 00:22:15,120
BUDGET HAS BEEN HIGHER THAN THE

498
00:22:15,120 --> 00:22:16,121
PRESIDENTIAL BUDGET.

499
00:22:16,121 --> 00:22:18,757
WHY AM IMMENSING THIS AND

500
00:22:18,757 --> 00:22:21,393
BRINGING THIS TO YOUR ATTENTION?

501
00:22:21,393 --> 00:22:25,431
* BECAUSE THE FY23 BUDGET THAT

502
00:22:25,431 --> 00:22:28,567
CAME OUT A COUPLE OF MONTHS AGO

503
00:22:28,567 --> 00:22:32,738
ACTUALLY FOR NCI IS LOWER THAN

504
00:22:32,738 --> 00:22:37,476
THE ACTUAL ENACTED BUDGET FOR  

505
00:22:37,476 --> 00:22:39,578
FY22 BY ABOUT $200 MILLION.

506
00:22:39,578 --> 00:22:41,480
AND AS SHOWN ON THE RIGHT

507
00:22:41,480 --> 00:22:43,482
CONGRESS HAS DECLINED TO CUT

508
00:22:43,482 --> 00:22:45,584
FUNDING FOR CANCER RESEARCH EVEN

509
00:22:45,584 --> 00:22:48,587
IN CHALLENGING BUDGET CYCLES.

510
00:22:48,587 --> 00:22:52,558
AND INDEED LAST WEEK AS SHOWN ON

511
00:22:52,558 --> 00:22:55,227
THE BOTTOM THE HOUSE

512
00:22:55,227 --> 00:22:57,429
APPROPRIATIONS SUBCOMMITTEE CAME

513
00:22:57,429 --> 00:23:00,732
OUT WITH THEIR MARK AND THEY ARE

514
00:23:00,732 --> 00:23:05,170
PROPOSING A $466 MILLION

515
00:23:05,170 --> 00:23:09,675
INCREASE OVER THE ENACTED AMOUNT

516
00:23:09,675 --> 00:23:14,480
FOR FY22 WHICH IS ACTUALLY

517
00:23:14,480 --> 00:23:18,784
$665 MILLION HIGHER THAN THE

518
00:23:18,784 --> 00:23:19,384
PROPOSED BUDGET.

519
00:23:19,384 --> 00:23:22,154
NOW OF COURSE, THE SENATE NEEDS

520
00:23:22,154 --> 00:23:24,122
TO WEIGH IN AND IT'S CRITICALLY

521
00:23:24,122 --> 00:23:28,126
IMPORTANT FOR ADVOCACY

522
00:23:28,126 --> 00:23:29,995
COMMUNITY, CANCER RESEARCH

523
00:23:29,995 --> 00:23:32,764
COMMUNITY AND MANY OTHER

524
00:23:32,764 --> 00:23:35,200
STAKEHOLDERS TO WEIGH IN ON THE

525
00:23:35,200 --> 00:23:38,504
OPPORTUNITIES THAT WE HAVE IN

526
00:23:38,504 --> 00:23:39,872
CANCER RESEARCH BECAUSE THE

527
00:23:39,872 --> 00:23:42,508
BUDGET DOES NOT GET PASSED JUST

528
00:23:42,508 --> 00:23:44,610
BY ITSELF.

529
00:23:44,610 --> 00:23:47,112
BUT IT REQUIRES HEAVY LIFTING ON

530
00:23:47,112 --> 00:23:49,114
THE PART OF MANY DIFFERENT

531
00:23:49,114 --> 00:23:50,215
PEOPLE.

532
00:23:50,215 --> 00:23:54,520
I AM NOT GOING TO TALK ABOUT

533
00:23:54,520 --> 00:23:58,924
ARPA-H BUT HOLLY GIBBONS HAS A

534
00:23:58,924 --> 00:24:01,693
SLIDE ABOUT ARPA-H BUT I WILL BE

535
00:24:01,693 --> 00:24:04,663
HAPPY TO ANSWER QUESTIONS ABOUT

536
00:24:04,663 --> 00:24:09,568
IT DURING THE Q&A PERIOD.

537
00:24:09,568 --> 00:24:12,371
SO THE NEXT SLIDE TELLS YOU

538
00:24:12,371 --> 00:24:15,007
ABOUT ANOTHER ACTIVITY THAT

539
00:24:15,007 --> 00:24:15,707
OCCURRED.

540
00:24:15,707 --> 00:24:17,409
THIS WAS TWO WEEKS AGO.

541
00:24:17,409 --> 00:24:20,946
THE NCI PARTNERED WITH CANCER

542
00:24:20,946 --> 00:24:27,085
RESEARCH UK TO DO REALLY THESE

543
00:24:27,085 --> 00:24:31,390
BIG PROBLEMS IN CANCER.

544
00:24:31,390 --> 00:24:37,663
AND WE PARTNERED 50/50 WITH CRUK

545
00:24:37,663 --> 00:24:40,198
TO BE ABLE TO BE ABLE TO MAKE

546
00:24:40,198 --> 00:24:41,233
FOUR AWARDS.

547
00:24:41,233 --> 00:24:43,135
WE WERE INVOLVED IN THE REVIEW

548
00:24:43,135 --> 00:24:45,837
PROCESS.

549
00:24:45,837 --> 00:24:50,776
AND THESE ARE THE FOUR AWARDS

550
00:24:50,776 --> 00:24:53,312
THAT WERE ANNOUNCED.

551
00:24:53,312 --> 00:24:57,749
THESE ARE SUBSTANTIALLY LARGER

552
00:24:57,749 --> 00:24:59,318
THAN ANY OF THE ORDINARY AWARDS

553
00:24:59,318 --> 00:25:01,119
THAT WE MAKE WHICH IS ONE OF THE

554
00:25:01,119 --> 00:25:06,124
THINGS THAT EXCITED US ABOUT

555
00:25:06,124 --> 00:25:10,062
PARTICIPATING IN THE GRANT

556
00:25:10,062 --> 00:25:11,563
CHALLENGES AND ON THE BOTTOM

557
00:25:11,563 --> 00:25:14,533
LEFT ARE SHOWN THE FOUR

558
00:25:14,533 --> 00:25:16,635
DIFFERENT GROUPS OF WHAT IS

559
00:25:16,635 --> 00:25:18,203
GOING TO BE EXPLORED.

560
00:25:18,203 --> 00:25:22,074
ONE IS THE IMPORTANT AREA OF

561
00:25:22,074 --> 00:25:26,144
CANCER -- ANOTHER IS LOOKING AT

562
00:25:26,144 --> 00:25:29,615
EXTRA CHROMOSOMAL DNA.

563
00:25:29,615 --> 00:25:34,152
THE THIRD IS ENGINEERED TC

564
00:25:34,152 --> 00:25:36,154
THERAPIES FOR CHILDHOOD CANCER

565
00:25:36,154 --> 00:25:39,658
AND THE FOURTH IS TO BETTER

566
00:25:39,658 --> 00:25:41,460
UNDERSTAND WHAT TRIGGERS NORMAL

567
00:25:41,460 --> 00:25:48,200
CELLS TO BECOME CANCEROUS WITH A

568
00:25:48,200 --> 00:25:50,836
LONG-TERM GOAL OF TRYING TO

569
00:25:50,836 --> 00:25:52,137
INFORM CANCER PREVENTION.

570
00:25:52,137 --> 00:25:55,574
IF YOU'RE WONDERING THE

571
00:25:55,574 --> 00:25:57,075
$100 MILLION IS OVER A FIVE-YEAR

572
00:25:57,075 --> 00:25:59,011
PERIOD AND OUR CONTRIBUTION IS

573
00:25:59,011 --> 00:26:01,713
HALF OF THAT.

574
00:26:01,713 --> 00:26:05,851
SO THE ANNUAL INVESTMENT IS

575
00:26:05,851 --> 00:26:09,554
SMALLER BUT ALSO DUDS THIS MEAN

576
00:26:09,554 --> 00:26:11,657
THAT * MONEY IS GOING OUTSIDE

577
00:26:11,657 --> 00:26:13,191
THE UNITED STATES FOR RESEARCH?

578
00:26:13,191 --> 00:26:17,396
AND I CAN ASSURE YOU THAT ABOUT

579
00:26:17,396 --> 00:26:21,733
60% OF THE FUNDING THAT IS BEING

580
00:26:21,733 --> 00:26:23,735
PROVIDED HERE IS IN THE UNITED

581
00:26:23,735 --> 00:26:25,470
STATES.

582
00:26:25,470 --> 00:26:28,607
 ACTUALLY WILL BE A NET

583
00:26:28,607 --> 00:26:32,310
INFLOW OF RESEARCH -- FUNDING

584
00:26:32,310 --> 00:26:33,712
INTO THE UNITED STATES BUT THESE

585
00:26:33,712 --> 00:26:37,749
ARE ALL INTERNATIONAL GROUPS AND

586
00:26:37,749 --> 00:26:40,052
WE FEEL THAT THESE INTERNATIONAL

587
00:26:40,052 --> 00:26:42,120
GROUPS ARE GOING TO BE ABLE TO

588
00:26:42,120 --> 00:26:44,790
MAKE SUBSTANTIAL PROGRESS ON

589
00:26:44,790 --> 00:26:49,327
THEIR VARIOUS PROJECTS.

590
00:26:49,327 --> 00:26:51,296
THE NEXT SLIDE IS SOMETHING THAT

591
00:26:51,296 --> 00:26:54,132
I WISH I DID NOT NEED TO TALK

592
00:26:54,132 --> 00:26:55,400
ABOUT BUT IT IS IMPORTANT.

593
00:26:55,400 --> 00:27:00,105
NEXT SLIDE, PLEASE.

594
00:27:00,105 --> 00:27:03,608
AND THIS IS THE INCREASE IN

595
00:27:03,608 --> 00:27:06,278
UTERINE CANCER DEATH RATES HAVE

596
00:27:06,278 --> 00:27:09,181
BEEN RISING AND HIGHEST AMONG

597
00:27:09,181 --> 00:27:09,881
BLACK WOMEN IN THE UNITED

598
00:27:09,881 --> 00:27:10,148
STATES.

599
00:27:10,148 --> 00:27:15,654
THERE WAS A PAPER PUBLISHED BY

600
00:27:15,654 --> 00:27:18,023
MEGHAN CLARKE AND HER COLLEAGUES

601
00:27:18,023 --> 00:27:19,791
FROM THE INTERMURAL PROGRAM AND

602
00:27:19,791 --> 00:27:22,761
THIS HIGHLIGHTS ON THE LEFT SOME

603
00:27:22,761 --> 00:27:28,533
OF THE KEY ASPECTS OF THIS OF

604
00:27:28,533 --> 00:27:29,501
THE FINDINGS.

605
00:27:29,501 --> 00:27:32,104
BLACK WOMEN ARE TWICE AS LIKELY

606
00:27:32,104 --> 00:27:35,507
TO DIE OF UTERINE CANCER

607
00:27:35,507 --> 00:27:39,644
COMPARED WITH WOMEN OF OTHER

608
00:27:39,644 --> 00:27:42,147
RACIAL AND ETHNIC GROUPS.

609
00:27:42,147 --> 00:27:45,817
MOST OF THE MORTALITY INCREASES

610
00:27:45,817 --> 00:27:51,556
A TRIPLABLE TO NONENDO METEORITE

611
00:27:51,556 --> 00:27:55,527
UTERINE CANCER * WHICH

612
00:27:55,527 --> 00:27:57,829
DISPROPORTIONATELY AEFFECTS LOOK

613
00:27:57,829 --> 00:28:01,600
AND NOW HISPANIC WOMEN.

614
00:28:01,600 --> 00:28:04,970
INCREASED 3.5% FOR BLACK WOMEN

615
00:28:04,970 --> 00:28:07,539
AND IN EVEN MORE ALARMING RATE

616
00:28:07,539 --> 00:28:10,475
FOR HISPANIC WOMEN.

617
00:28:10,475 --> 00:28:13,578
AT 6.7%.

618
00:28:13,578 --> 00:28:18,617
THIS ENTITY OF CANCER ONLY

619
00:28:18,617 --> 00:28:22,921
REPRESENTS ABOUT 20% OF UTERINE

620
00:28:22,921 --> 00:28:25,724
CANCER IN TERMS OF INCIDENTS BUT

621
00:28:25,724 --> 00:28:29,127
IT'S MORE THAN 40% OF MORTALITY

622
00:28:29,127 --> 00:28:30,428
RATES.

623
00:28:30,428 --> 00:28:33,031
SO THERE IS AN URGENT NEED FOR

624
00:28:33,031 --> 00:28:36,568
NEW RESEARCH IN THE AFFECTED

625
00:28:36,568 --> 00:28:37,302
POPULATIONS.

626
00:28:37,302 --> 00:28:41,206
I HAD A DISCUSSION YESTERDAY

627
00:28:41,206 --> 00:28:44,109
WITH THE FIRST AUTHOR MEGHAN

628
00:28:44,109 --> 00:28:46,278
CLARKE AND THE LAST AUTHOR OF

629
00:28:46,278 --> 00:28:49,481
THE PUBLICATION -- NICO -- AND

630
00:28:49,481 --> 00:28:50,916
WE'RE GOING TO BE DISCUSSING

631
00:28:50,916 --> 00:28:52,884
THIS WHAT KIND OF RESEARCH NEEDS

632
00:28:52,884 --> 00:28:59,391
IN A COUPLE OF WEEKS IN -- AT

633
00:28:59,391 --> 00:29:02,427
THE NCI AND THEN BROADENING THAT

634
00:29:02,427 --> 00:29:04,963
DISCUSSION PROBABLY TO INVOLVE

635
00:29:04,963 --> 00:29:07,165
OTHERS AS WELL.

636
00:29:07,165 --> 00:29:17,309
THE NEXT SLIDE TELLS YOU TH -- T

637
00:29:17,309 --> 00:29:19,044
IT'S NOT ALL BAD NEWS.

638
00:29:19,044 --> 00:29:21,880
THE CANCER ISSUE IS AN OUTLIER

639
00:29:21,880 --> 00:29:23,381
BECAUSE AS SHOWN HERE ON THE

640
00:29:23,381 --> 00:29:28,920
LEFT AND ON THE RIGHT IS THAT

641
00:29:28,920 --> 00:29:30,922
ANOTHER AFRICAN-AMERICAN MEN AND

642
00:29:30,922 --> 00:29:33,792
WOMEN STILL HAVE HIGHER

643
00:29:33,792 --> 00:29:36,328
MORTALITY RATES THAN OTHER

644
00:29:36,328 --> 00:29:39,231
GROUPS ESPECIALLY FOR

645
00:29:39,231 --> 00:29:41,399
AFRICAN-AMERICAN MEN IN THE LAST

646
00:29:41,399 --> 00:29:44,636
20 YEARS THE GAP IN THE

647
00:29:44,636 --> 00:29:48,607
MORTALITY RATES HAS REALLY

648
00:29:48,607 --> 00:29:52,143
NARROWED BETWEEN BLACK AND

649
00:29:52,143 --> 00:29:54,379
WHITES.

650
00:29:54,379 --> 00:29:57,649
AND THIS IS TRUE FOR ESSENTIALLY

651
00:29:57,649 --> 00:30:01,887
ALL RACIAL AND ETHNIC GROUPS BUT

652
00:30:01,887 --> 00:30:04,589
WITH THE NOTABLE EXCEPTION OF

653
00:30:04,589 --> 00:30:06,725
THE PACIFIC ISLANDERS AND NATIVE

654
00:30:06,725 --> 00:30:09,294
AMERICANS AND THAT IS SHOWN BY

655
00:30:09,294 --> 00:30:10,228
THE ORANGE LINE.

656
00:30:10,228 --> 00:30:15,467
AND WE NEED TO DO MORE SO THAT

657
00:30:15,467 --> 00:30:18,169
THEY CAN BENEFIT FROM THE

658
00:30:18,169 --> 00:30:20,171
ADVANCES THAT WE'VE HAD IN

659
00:30:20,171 --> 00:30:20,572
CANCER RESEARCH.

660
00:30:20,572 --> 00:30:22,540
NEXT SLIDE.

661
00:30:22,540 --> 00:30:24,242
SO THE NEXT SLIDE IS SOMETHING

662
00:30:24,242 --> 00:30:27,545
THAT I'VE TAKEN FROM THE LUNG

663
00:30:27,545 --> 00:30:28,880
CANCER RESEARCH FOUNDATION.

664
00:30:28,880 --> 00:30:32,183
BECAUSE I THINK IT REALLY IS AN

665
00:30:32,183 --> 00:30:39,090
INTERESTING DEPICTION OF THE

666
00:30:39,090 --> 00:30:41,259
ADVANCES IN CANCER TREATMENT FOR

667
00:30:41,259 --> 00:30:44,095
LUNG CANCER.

668
00:30:44,095 --> 00:30:48,033
AND THE BLUE OR THE TARGETED

669
00:30:48,033 --> 00:30:49,634
TREATMENTS THAT HAVE BEEN

670
00:30:49,634 --> 00:30:53,071
APPROVED AND THE BLACK PARTS THE

671
00:30:53,071 --> 00:30:56,608
IMMUNO THERAPY AND THEY ARE ALL

672
00:30:56,608 --> 00:30:59,544
HEAVILY SKEWED TOWARD THE LAST

673
00:30:59,544 --> 00:31:00,245
20 YEARS.

674
00:31:00,245 --> 00:31:03,448
AND MOST OF THEM TOWARDS THE

675
00:31:03,448 --> 00:31:06,518
LAST 10-15 YEARS.

676
00:31:06,518 --> 00:31:09,621
AND I WAS CO-AUTHOR OF A PAPER

677
00:31:09,621 --> 00:31:12,857
PUBLISHED TWO YEARS AGO ON THE

678
00:31:12,857 --> 00:31:15,026
EFFECTIVE ADVANCES IN LUNG CAN

679
00:31:15,026 --> 00:31:17,028
TREATMENT AND POPULATION

680
00:31:17,028 --> 00:31:17,796
MORTALITY.

681
00:31:17,796 --> 00:31:21,333
AND THE REFERENCE IS SHOWN BELOW

682
00:31:21,333 --> 00:31:23,635
BECAUSE WHILE A LOT OF THE

683
00:31:23,635 --> 00:31:26,104
DECREASE IN MORTALITY FROM LUNG

684
00:31:26,104 --> 00:31:29,874
CANCER IS BECAUSE OF DECREASED

685
00:31:29,874 --> 00:31:31,810
TOBACCO CONSUMPTION NOW AS A

686
00:31:31,810 --> 00:31:34,612
RESULT OF ALL OF THE THESE

687
00:31:34,612 --> 00:31:38,416
APPROVALS THERE ALSO IS

688
00:31:38,416 --> 00:31:40,452
SUBSTANTIAL BENEFIT FOR CANCER

689
00:31:40,452 --> 00:31:41,319
TREATMENT.

690
00:31:41,319 --> 00:31:43,855
NEEDLESS TO SAY MANY TOO MANY

691
00:31:43,855 --> 00:31:45,790
PEOPLE ARE DYING FROM CANCER IN

692
00:31:45,790 --> 00:31:47,926
GENERAL AND LUNG CANCER

693
00:31:47,926 --> 00:31:50,528
SPECIFICALLY AND WE NEED TO

694
00:31:50,528 --> 00:31:52,464
REDOUBLE OUR EFFORTS IN ALL OF

695
00:31:52,464 --> 00:31:54,899
THESE AREAS.

696
00:31:54,899 --> 00:31:57,035
THE NEXT SLIDE -- TALKS ABOUT

697
00:31:57,035 --> 00:32:00,705
ONE OF THE AREAS WHERE WE HAVE

698
00:32:00,705 --> 00:32:02,307
NOT BEEN VERY SUCCESSFUL.

699
00:32:02,307 --> 00:32:08,113
AND THAT IS IN PANCREATIC CANCER

700
00:32:08,113 --> 00:32:09,948
RESEARCH.

701
00:32:09,948 --> 00:32:13,118
RECENTLY THERE IS -- HAS STARTED

702
00:32:13,118 --> 00:32:16,721
A PANCREATIC CANCER VACCINE

703
00:32:16,721 --> 00:32:22,193
WHICH TARGETS MUTATIONS IN K-RAS

704
00:32:22,193 --> 00:32:25,797
THAT OCCUR IN MORE THAN 80% OF

705
00:32:25,797 --> 00:32:29,100
PEOPLE WITH PANCREATIC CANCER

706
00:32:29,100 --> 00:32:31,536
AND YOU WILL BE HEARING FROM

707
00:32:31,536 --> 00:32:34,072
DR. CASTLE ABOUT THE

708
00:32:34,072 --> 00:32:36,074
MULTI-CANCER DETECTION SCREENING

709
00:32:36,074 --> 00:32:38,176
MANY OF WHICH INCLUDE SCREENING

710
00:32:38,176 --> 00:32:43,148
FOR PANCREATIC CANCER.

711
00:32:43,148 --> 00:32:45,650
AND THERE ALSO ARE OPPORTUNITIES

712
00:32:45,650 --> 00:32:47,852
FOR TREATMENT.

713
00:32:47,852 --> 00:32:54,359
I'VE HIGHLIGHTED MUTANT KRAS

714
00:32:54,359 --> 00:33:00,331
BECAUSE IT'S SO COMMON IN

715
00:33:00,331 --> 00:33:03,468
PANCREATIC CANCER BUT KRAS WAS

716
00:33:03,468 --> 00:33:05,937
THOUGHT TO BE AN UNDRUGGABLE

717
00:33:05,937 --> 00:33:07,806
TARGET AND LAST YEAR THANKS TO

718
00:33:07,806 --> 00:33:13,978
BREAKTHROUGH RESEARCH -- THE

719
00:33:13,978 --> 00:33:18,716
FIRST FDA TREATMENT FOR MUTANT

720
00:33:18,716 --> 00:33:21,486
KRAS WAS APPROVED FOR LUNG

721
00:33:21,486 --> 00:33:24,456
CANCER WHERE MORE THAN ONE-HALF

722
00:33:24,456 --> 00:33:29,661
OF LUNG CANCERS WITH MUTANT KRAS

723
00:33:29,661 --> 00:33:34,399
HAVE THIS PARTICULAR MUTATION.

724
00:33:34,399 --> 00:33:40,505
AND THE REASON I'M SHOWING G12D

725
00:33:40,505 --> 00:33:44,209
IS THAT G12D ACCOUNTS FOR ABOUT

726
00:33:44,209 --> 00:33:50,949
60% OF THE MUTANT, AS IN PAN YE

727
00:33:50,949 --> 00:33:54,552
YACHTIC CANCER WHEREAS G12C IS

728
00:33:54,552 --> 00:33:59,190
VERY UNCOMMON.

729
00:33:59,190 --> 00:34:00,959
THERE IS INFORMATION SUGGESTING

730
00:34:00,959 --> 00:34:03,595
THAT INHIBITORS MAY ACTUALLY BE

731
00:34:03,595 --> 00:34:08,466
USEFUL EARLY PHASE TRIALS -- FOR

732
00:34:08,466 --> 00:34:10,101
SEVERAL INHIBITORS WILL BE

733
00:34:10,101 --> 00:34:12,170
STARTED IN OVER THE NEXT YEAR.

734
00:34:12,170 --> 00:34:15,273
AND I WILL SIMPLY POINT OUT THAT

735
00:34:15,273 --> 00:34:18,576
ONE OF MY NEIGHBORS HAS

736
00:34:18,576 --> 00:34:20,478
PANCREATIC CANCER.

737
00:34:20,478 --> 00:34:22,013
HE STILL HAS LESIONS.

738
00:34:22,013 --> 00:34:23,581
HE IS DOING WELL.

739
00:34:23,581 --> 00:34:28,987
BUT HE HAS G12D MUTATION AND IT

740
00:34:28,987 --> 00:34:30,622
WOULD BE EXTRAORDINARILY

741
00:34:30,622 --> 00:34:33,625
BENEFICIAL FOR HIM IF THOSE

742
00:34:33,625 --> 00:34:35,927
CLINICAL TRIALS WERE TO BE

743
00:34:35,927 --> 00:34:36,661
SUCCESSFUL.

744
00:34:36,661 --> 00:34:39,697
AND OBVIOUSLY FOR LOTS OF PEOPLE

745
00:34:39,697 --> 00:34:42,000
WITH PANCREATIC CANCER.

746
00:34:42,000 --> 00:34:45,336
SO I WOULD LIKE TO TURN NOW TO

747
00:34:45,336 --> 00:34:48,006
THE LAST TOPIC WHICH IS THE

748
00:34:48,006 --> 00:34:51,643
CANCER MOONSHOT.

749
00:34:51,643 --> 00:34:55,013
AND THIS SLIDE -- THE NEXT SLIDE

750
00:34:55,013 --> 00:34:57,215
TELLS YOU ABOUT THE CURRENT

751
00:34:57,215 --> 00:35:01,219
PHASE OF THE CANCER MOONSHOT

752
00:35:01,219 --> 00:35:04,923
WHICH STARTED IN 2017 WITH

753
00:35:04,923 --> 00:35:05,557
FUNDING.

754
00:35:05,557 --> 00:35:09,160
AND IT REALLY HAS BEEN VERY

755
00:35:09,160 --> 00:35:13,097
SUCCESSFUL BUT IT'S -- WE STILL

756
00:35:13,097 --> 00:35:15,200
HAVE LOTS AND LOTS OF CANCER.

757
00:35:15,200 --> 00:35:20,405
BUT BY VARIOUS METRICS MORE THAN

758
00:35:20,405 --> 00:35:23,441
2,000 PUBLICATIONS ALMOST 50

759
00:35:23,441 --> 00:35:25,743
CLINICAL TRIALS AND MORE THAN 30

760
00:35:25,743 --> 00:35:27,278
PATENT FILINGS.

761
00:35:27,278 --> 00:35:30,114
BUT AS MANY OF YOU ARE AWARE THE

762
00:35:30,114 --> 00:35:33,117
NEXT FISCAL YEAR FY23 IS THE

763
00:35:33,117 --> 00:35:36,988
LAST YEAR WHERE WE HAVE FUNDING

764
00:35:36,988 --> 00:35:39,490
FOR THE CANCER MOONSHOT FOR THIS

765
00:35:39,490 --> 00:35:39,891
PHASE.

766
00:35:39,891 --> 00:35:41,759
AND IT'S REALLY IMPORTANT TO

767
00:35:41,759 --> 00:35:44,095
CONTINUE TO SUPPORT THE MOST

768
00:35:44,095 --> 00:35:46,531
PROMISING INITIATIVES FROM THE

769
00:35:46,531 --> 00:35:48,666
INITIAL CANCER MOONSHOT WHILE

770
00:35:48,666 --> 00:35:50,401
ALSO DEVELOPING ADDITIONAL

771
00:35:50,401 --> 00:35:52,570
ACTIVITIES TO MEET CHALLENGING

772
00:35:52,570 --> 00:35:53,738
NEW GOALS.

773
00:35:53,738 --> 00:35:59,310
SO THE NEXT SLIDE WHICH IS

774
00:35:59,310 --> 00:36:02,914
ANIMATED TELLS YOU ABOUT THE

775
00:36:02,914 --> 00:36:04,015
ANNOUNCEMENT THAT PRESIDENT

776
00:36:04,015 --> 00:36:07,919
BIDEN MADE IN FEBRUARY.

777
00:36:07,919 --> 00:36:09,187
ABOUT SOME OF THE GOALS OF THE

778
00:36:09,187 --> 00:36:10,955
NEXT PHASE OF THE CANCER

779
00:36:10,955 --> 00:36:11,956
MOONSHOT.

780
00:36:11,956 --> 00:36:14,592
THE FIRST GOAL IS TO CUT THE

781
00:36:14,592 --> 00:36:17,629
CANCER DEATH RATE IN HALF.

782
00:36:17,629 --> 00:36:20,164
WITHIN THE NEXT 25 YEARS.

783
00:36:20,164 --> 00:36:22,567
THE SECOND IS TO TRANSFORM THE

784
00:36:22,567 --> 00:36:24,769
MEANING OF CANCER.

785
00:36:24,769 --> 00:36:28,539
AND THE THIRD TO ADDRESS CANCER

786
00:36:28,539 --> 00:36:31,009
ASSOCIATED INEQUITIES.

787
00:36:31,009 --> 00:36:34,012
BEFORE WE LEAVE THIS SLIDE ONE

788
00:36:34,012 --> 00:36:35,947
OF THE THINGS THAT I'VE ASKED

789
00:36:35,947 --> 00:36:41,119
SOME COLLEAGUES TO DO IS REALLY

790
00:36:41,119 --> 00:36:43,855
LOOK CRITICALLY AT WHAT NEEDS TO

791
00:36:43,855 --> 00:36:45,957
HAPPEN TO BE ABLE TO CUT THE

792
00:36:45,957 --> 00:36:48,960
CANCER DEATH RATE AT LEAST IN

793
00:36:48,960 --> 00:36:51,896
HALF WITHIN THE NEXT 25 YEARS.

794
00:36:51,896 --> 00:36:54,399
AND THEY HAVE BEEN -- MEETING

795
00:36:54,399 --> 00:36:56,968
AND I HOPE THEY WILL BE ABLE TO

796
00:36:56,968 --> 00:37:00,338
HAVE A PEER REVIEW PUBLICATION

797
00:37:00,338 --> 00:37:03,274
SUBMITTED IN THE NEXT FEW MONTHS

798
00:37:03,274 --> 00:37:05,476
TO TAKE THESE ASPIRATIONAL GOALS

799
00:37:05,476 --> 00:37:07,979
AND SHOW HOW THEY ACTUALLY COULD

800
00:37:07,979 --> 00:37:10,848
BE FEASIBLE.

801
00:37:10,848 --> 00:37:13,951
THE NEXT SLIDE TELLS YOU ABOUT

802
00:37:13,951 --> 00:37:16,888
FOUR DIFFERENT AREAS THAT I

803
00:37:16,888 --> 00:37:19,123
THINK WE COULD TRY TO GIVE

804
00:37:19,123 --> 00:37:23,127
EMPHASIS TO.

805
00:37:23,127 --> 00:37:29,734
OF TRYING TO MAKE FEASIBLE THE

806
00:37:29,734 --> 00:37:32,003
ASPIRATIONAL GOAL OF THE BIDEN

807
00:37:32,003 --> 00:37:32,470
ADMINISTRATION.

808
00:37:32,470 --> 00:37:34,472
THE FIRST IS TO INVEST IN THE

809
00:37:34,472 --> 00:37:39,277
PIPELINE OF NEW DRUGS FOR CANCER

810
00:37:39,277 --> 00:37:42,180
PREVENTION, INTERCEPTION AND FOR

811
00:37:42,180 --> 00:37:43,815
TREATMENT.

812
00:37:43,815 --> 00:37:47,118
AND I SHOULD ALSO INCLUDE

813
00:37:47,118 --> 00:37:47,618
DIAGNOSTICS.

814
00:37:47,618 --> 00:37:49,687
FOR EXAMPLE WHAT DR. CASTLE WILL

815
00:37:49,687 --> 00:37:52,757
BE TALKING ABOUT WITH THE

816
00:37:52,757 --> 00:37:55,059
MULTI-CANCER DETECTION TEST.

817
00:37:55,059 --> 00:37:56,861
EVEN IF WE CAN DECREASE

818
00:37:56,861 --> 00:38:01,899
MORTALITY OVER THE NEXT 25 YEARS

819
00:38:01,899 --> 00:38:04,035
BY 50% WE WILL NOT HAVE ENDED

820
00:38:04,035 --> 00:38:05,937
CANCER AS WE KNOW IT.

821
00:38:05,937 --> 00:38:10,074
IF WE DON'T MAKE PROGRESS ON

822
00:38:10,074 --> 00:38:12,043
PANCREATIC CANCER AND OTHER

823
00:38:12,043 --> 00:38:15,046
CANCERS WHERE MORTALITY RATES

824
00:38:15,046 --> 00:38:19,016
ARE REMAIN SO HIGH.

825
00:38:19,016 --> 00:38:21,252
SECOND EXPANDING CLINICAL TRIALS

826
00:38:21,252 --> 00:38:25,089
TO SPEED THE EVALUATION OF

827
00:38:25,089 --> 00:38:25,823
CANDIDATE INTERVENTIONS.

828
00:38:25,823 --> 00:38:28,760
ABSOLUTELY CRITICAL AS WE ARE

829
00:38:28,760 --> 00:38:30,695
INVESTING AND EXPANDING THE

830
00:38:30,695 --> 00:38:32,463
PIPELINE WE NEED TO BE ABLE TO

831
00:38:32,463 --> 00:38:34,999
TEST THOSE NEW DRUGS THAT COME

832
00:38:34,999 --> 00:38:35,800
OUT.

833
00:38:35,800 --> 00:38:38,703
THIRD, WE NEED TO ENSURE

834
00:38:38,703 --> 00:38:40,705
EQUITABLE HEALTH CARE DELIVERY.

835
00:38:40,705 --> 00:38:42,073
BOTH OF CURRENT STANDARDS OF

836
00:38:42,073 --> 00:38:44,108
CARE AS WELL AS NEW STANDARDS OF

837
00:38:44,108 --> 00:38:45,109
CARE.

838
00:38:45,109 --> 00:38:50,648
AND SO IMPLEMENTATION RESEARCH

839
00:38:50,648 --> 00:38:51,883
WILL BE VERY IMPORTANT.

840
00:38:51,883 --> 00:38:54,652
AND FOURTH, TO INCREASE THE

841
00:38:54,652 --> 00:38:56,988
DIVERSITY OF CANCER RESEARCH AND

842
00:38:56,988 --> 00:39:00,091
WORKFORCE SO IT CLOSELY

843
00:39:00,091 --> 00:39:03,094
RESEMBLES THE COMMUNITIES THAT

844
00:39:03,094 --> 00:39:04,462
WE SERVE.

845
00:39:04,462 --> 00:39:07,899
THE NEXT SLIDE TELLS YOU THAT

846
00:39:07,899 --> 00:39:10,635
WE'RE ALREADY TRYING TO

847
00:39:10,635 --> 00:39:13,704
JUMP-START THE NEXT PHASE OF THE

848
00:39:13,704 --> 00:39:15,039
MOONSHOT ALTHOUGH WE DON'T

849
00:39:15,039 --> 00:39:18,309
IMAGINE GETTING NEW FUNDING

850
00:39:18,309 --> 00:39:20,278
UNTIL FY24.

851
00:39:20,278 --> 00:39:25,049
SO TWO WEEKS AGO -- AT OUR

852
00:39:25,049 --> 00:39:28,553
NATIONAL CANCER ADVISORY BOARD

853
00:39:28,553 --> 00:39:32,924
AND BOARD MEETING TWO OF THE

854
00:39:32,924 --> 00:39:34,826
PRESENTATIONS WERE MADE ONE WAS

855
00:39:34,826 --> 00:39:37,695
FOR THE CANCER MOONSHOT SCHOLARS

856
00:39:37,695 --> 00:39:38,796
DIVERSITY PROGRAM.

857
00:39:38,796 --> 00:39:41,866
AND THE SECOND WAS THE

858
00:39:41,866 --> 00:39:43,334
FEASIBILITY TRIAL FOR

859
00:39:43,334 --> 00:39:46,537
ASYMPTOMATIC MULTI-CANCER

860
00:39:46,537 --> 00:39:47,371
DETECTION SCREENING THAT

861
00:39:47,371 --> 00:39:49,140
DR. CARS EL WILL TALK TO YOU

862
00:39:49,140 --> 00:39:52,910
ABOUT AND I'M * PLEASED TO TELL

863
00:39:52,910 --> 00:39:55,112
YOU ABOUT THAT OUR ADVISORY

864
00:39:55,112 --> 00:39:56,647
COMMITTEE WAS UNANIMOUS IN THEIR

865
00:39:56,647 --> 00:39:59,917
STRONG ENDORSEMENT OF BOTH OF

866
00:39:59,917 --> 00:40:01,319
THESE PROPOSALS SO WE LOOK

867
00:40:01,319 --> 00:40:03,187
FORWARD IN GOING FORWARD WITH

868
00:40:03,187 --> 00:40:05,389
THEM IN FY23.

869
00:40:05,389 --> 00:40:08,526
AND THEN OTHER KINDS OF

870
00:40:08,526 --> 00:40:10,027
CONTINUITY WHERE THERE ARE

871
00:40:10,027 --> 00:40:11,529
NOTICES OF SPECIAL INTEREST OR

872
00:40:11,529 --> 00:40:15,032
REQUEST FOR INFORMATION FOR

873
00:40:15,032 --> 00:40:16,501
ADAPTING VISUALIZATION METHODS

874
00:40:16,501 --> 00:40:22,306
TO ENHANCE CANCER MOONSHOT DATA.

875
00:40:22,306 --> 00:40:33,651
AND HARM-- AND H-AND THE CHILDHH

876
00:40:36,954 --> 00:40:38,155
CONTINUE TO BE A VERY IMPORTANT

877
00:40:38,155 --> 00:40:40,091
GOAL.

878
00:40:40,091 --> 00:40:43,327
THE NEXT SLIDE -- COMES BACK THE

879
00:40:43,327 --> 00:40:45,596
PREVIOUS SLIDE THAT I SHOWED YOU

880
00:40:45,596 --> 00:40:47,598
AND JUST TO TELL YOU ABOUT

881
00:40:47,598 --> 00:40:50,001
HIGHLIGHT -- TWO ASPECTS.

882
00:40:50,001 --> 00:40:52,803
ONE IS EXPANDING CLINICAL TRIALS

883
00:40:52,803 --> 00:40:55,706
TO SPEED THE EVALUATION OF

884
00:40:55,706 --> 00:40:57,141
CANDIDATE INTERVENTIONS IN

885
00:40:57,141 --> 00:40:59,210
DIVERSE POPULATIONS.

886
00:40:59,210 --> 00:41:01,245
AND THE SECOND ENSURING

887
00:41:01,245 --> 00:41:02,980
EQUITABLE HEALTH CARE DELIVERY.

888
00:41:02,980 --> 00:41:06,651
AND THESE ARE AREAS WHERE THE

889
00:41:06,651 --> 00:41:09,921
CANCER ADVOCACY COMMUNITY CAN

890
00:41:09,921 --> 00:41:12,924
REALLY PLAY KEY ROLES AND THESE

891
00:41:12,924 --> 00:41:16,561
ARE AREAS WHICH WE REALLY NEED

892
00:41:16,561 --> 00:41:18,629
TO DRAMATICALLY EXPAND SO THAT

893
00:41:18,629 --> 00:41:22,433
WE CAN HAVE MORE AND FASTER

894
00:41:22,433 --> 00:41:23,868
INTERVENTIONS FOR THE CLINICAL

895
00:41:23,868 --> 00:41:27,004
TRIALS AND SECOND, WE NEED TO

896
00:41:27,004 --> 00:41:29,974
EXPAND THE IMPLEMENTATION

897
00:41:29,974 --> 00:41:32,977
RESEARCH AND WIDER DISSEMINATION

898
00:41:32,977 --> 00:41:34,278
OF CURRENT AND NEW STANDARD OF

899
00:41:34,278 --> 00:41:37,815
CARE.

900
00:41:37,815 --> 00:41:40,318
WHAT ABOUT ADAPTING CLINICAL

901
00:41:40,318 --> 00:41:44,522
CANCER TRIALS DURING COVID?

902
00:41:44,522 --> 00:41:46,891
AND MANY OF YOU ARE AWARE THAT

903
00:41:46,891 --> 00:41:51,529
THIS WAS ACCELERATED BY THE NEED

904
00:41:51,529 --> 00:41:53,497
TO ADAPT TO THE COVID-19

905
00:41:53,497 --> 00:41:53,965
PANDEMIC.

906
00:41:53,965 --> 00:41:56,033
AND WHAT WE TRIED TO DO IS PUT

907
00:41:56,033 --> 00:41:58,469
THE PATIENT AT THE CENTER OF

908
00:41:58,469 --> 00:42:01,205
CLINICAL TRIALS ACTIVITY.

909
00:42:01,205 --> 00:42:04,508
WHICH THEN PERMITTED REMOTE

910
00:42:04,508 --> 00:42:04,976
CONSENTING.

911
00:42:04,976 --> 00:42:07,778
LABORATORY TESTING DONE AT HOME.

912
00:42:07,778 --> 00:42:09,113
DRUGS DELIVERED AT HOME AND

913
00:42:09,113 --> 00:42:13,417
REMOTE MONITORING AND AUDITING

914
00:42:13,417 --> 00:42:15,720
AND KEITH FLAHARTY AND OTHERS

915
00:42:15,720 --> 00:42:17,855
PUBLISHED A PAPER LAST YEAR

916
00:42:17,855 --> 00:42:19,557
WHICH VERY INFORMATIVE.

917
00:42:19,557 --> 00:42:24,295
SO THE REAL ISSUE IS WHAT CAN WE

918
00:42:24,295 --> 00:42:25,096
CONTINUE DOING?

919
00:42:25,096 --> 00:42:28,633
AND THE IDEA IS TO MAKE THESE

920
00:42:28,633 --> 00:42:30,668
NEW OPERATIONAL PROCESSES

921
00:42:30,668 --> 00:42:32,737
PERMANENT.

922
00:42:32,737 --> 00:42:36,707
AND THIS IS REGARDING -- MORE

923
00:42:36,707 --> 00:42:40,578
AND MORE O'ERAL AGENTS RATHER

924
00:42:40,578 --> 00:42:42,880
THAN AGENTS THAT NEED TO BE

925
00:42:42,880 --> 00:42:47,618
GIVEN -- PARENTALLY AND ADVANCE

926
00:42:47,618 --> 00:42:50,087
PRACTICE -- AND STUDY AGENT

927
00:42:50,087 --> 00:42:56,560
ORDERS AND IT MIGHT BE USEFUL AT

928
00:42:56,560 --> 00:42:58,262
I SUBSEQUENT MEETING TO TALK

929
00:42:58,262 --> 00:43:01,465
MORE IN DETAIL ABOUT WHAT THE

930
00:43:01,465 --> 00:43:04,035
PLANS ARE GOING FORWARD.

931
00:43:04,035 --> 00:43:09,740
THOSE ARE THE CONTINUE -- ARE TI

932
00:43:09,740 --> 00:43:10,708
WANTED TO MAKE.

933
00:43:10,708 --> 00:43:13,744
I WANT TO THANK ALL OF YOU ON

934
00:43:13,744 --> 00:43:17,014
THE NCRA FOR THE INCREDIBLE

935
00:43:17,014 --> 00:43:18,349
SERVICE THAT YOU PROVIDE NOT

936
00:43:18,349 --> 00:43:22,086
JUST ON THE NCRA BUT ALSO FOR

937
00:43:22,086 --> 00:43:24,822
ADVOCATING FOR THE IMPORTANCE OF

938
00:43:24,822 --> 00:43:31,462
CANCER RESEARCH AND REALLY FOR

939
00:43:31,462 --> 00:43:35,132
ITS URGENCY AS WAS MENTIONED

940
00:43:35,132 --> 00:43:36,934
EARLIER BECAUSE EVERY MONTH THAT

941
00:43:36,934 --> 00:43:38,936
WE WAIT IS A MONTH THAT THERE

942
00:43:38,936 --> 00:43:42,306
ARE MANY PEOPLE DYING AND A

943
00:43:42,306 --> 00:43:44,041
MONTH WHERE WE MIGHT HAD BEEN

944
00:43:44,041 --> 00:43:46,544
ABLE TO INTERVENE AND DO

945
00:43:46,544 --> 00:43:49,046
SOMETHING TO HELP PEOPLE EITHER

946
00:43:49,046 --> 00:43:51,015
PREVENT GETTING CANCER, DIAGNOSE

947
00:43:51,015 --> 00:43:52,516
IT EARLIER OR TREAT IT.

948
00:43:52,516 --> 00:43:53,951
SO I LOOK FORWARD TO YOUR

949
00:43:53,951 --> 00:43:55,152
QUESTIONS AND COMMENTS.

950
00:43:55,152 --> 00:43:59,623
THANKS VERY MUCH.

951
00:43:59,623 --> 00:44:02,359
>> THAT WAS A WONDERFUL
UPDATE.

952
00:44:02,359 --> 00:44:03,561
THANK YOU SO MUCH.

953
00:44:03,561 --> 00:44:05,362
I'LL OPEN IT UP TO QUESTIONS.

954
00:44:05,362 --> 00:44:07,531
ANY QUESTIONS AND I CAN JUMP IN

955
00:44:07,531 --> 00:44:09,900
AS WELL IF NEEDED.

956
00:44:09,900 --> 00:44:14,672
JENNIFER.

957
00:44:14,672 --> 00:44:17,408
>> YOU'RE MUTED.

958
00:44:17,408 --> 00:44:18,109
>> SORRY.

959
00:44:18,109 --> 00:44:21,011
MY MOUSE WAS NOT WORKING RIGHT.

960
00:44:21,011 --> 00:44:23,481
THANKS, DR. LOWY FOR THAT GREAT

961
00:44:23,481 --> 00:44:24,915
PRESENTATION AND WE'RE LOOKING

962
00:44:24,915 --> 00:44:26,350
FORWARD TO HAVING YOU AT OUR

963
00:44:26,350 --> 00:44:28,085
MEETING IN OCTOBER AS WELL.

964
00:44:28,085 --> 00:44:29,820
I WANT TO THANK YOU FOR YOUR

965
00:44:29,820 --> 00:44:32,289
REMARKS ON DIVERSITY AND

966
00:44:32,289 --> 00:44:33,224
CLINICAL TRIALS.

967
00:44:33,224 --> 00:44:34,925
WE'VE BEEN GATHERING DATA FOR

968
00:44:34,925 --> 00:44:38,462
THE LAST YEAR AND A HALF IN OUR

969
00:44:38,462 --> 00:44:40,831
CANCER CENTER ON DIVERSITY AND

970
00:44:40,831 --> 00:44:41,565
CLINICAL TRIALS.

971
00:44:41,565 --> 00:44:45,770
AND FOUND THAT MANY OF THE -- SO

972
00:44:45,770 --> 00:44:49,240
WE DIDN'T HA HAVE A GREAT RESPO.

973
00:44:49,240 --> 00:44:51,408
ABOUT 36 CANCER CENTERS

974
00:44:51,408 --> 00:44:54,945
RESPONDING BUT FROM THE YEARS TO

975
00:44:54,945 --> 00:44:59,350
19-2020 WE SAW THAT OUR CANCER

976
00:44:59,350 --> 00:45:02,419
CENTERS -- WERE LARGELY FEMALE.

977
00:45:02,419 --> 00:45:04,221
LARGELY WHITE SO I THINK IT'S

978
00:45:04,221 --> 00:45:06,991
VERY IMPORTANT THAT WE AS A

979
00:45:06,991 --> 00:45:15,533
COMMUNITY FOCUS ON DIVERSIFY

980
00:45:15,533 --> 00:45:16,834
CLINICAL TRIALS AND PATIENTS

981
00:45:16,834 --> 00:45:19,236
WANT TO HEAR FROM PEOPLE THAT

982
00:45:19,236 --> 00:45:20,704
LOOK LIKE THEM AND WITH STAFF

983
00:45:20,704 --> 00:45:21,438
RETENTION ISSUES.

984
00:45:21,438 --> 00:45:24,341
THERE IS A LOT OF CHALLENGES

985
00:45:24,341 --> 00:45:25,176
RIGHT NOW.

986
00:45:25,176 --> 00:45:26,844
SO I APPRECIATE YOU RAISING THIS

987
00:45:26,844 --> 00:45:28,612
ISSUE AND BRINGING IT UP.

988
00:45:28,612 --> 00:45:34,718
I LOOK FORWARD TO BEING ABLE TO

989
00:45:34,718 --> 00:45:36,921
SHARE THIS INFORMATION SOON.

990
00:45:36,921 --> 00:45:38,355
OF COURSE LOOK FORWARD TO

991
00:45:38,355 --> 00:45:40,691
WORKING WITH -- EVEN THOUGH I'M

992
00:45:40,691 --> 00:45:41,992
ROTATING OFF BUT SHARING WITH

993
00:45:41,992 --> 00:45:44,195
THE REST OF THE NCRA WAYS THAT

994
00:45:44,195 --> 00:45:46,096
WE MIGHT BE ABLE TO MOVE THE

995
00:45:46,096 --> 00:45:47,364
NEEDLE IN THIS AREA.

996
00:45:47,364 --> 00:45:48,666
BECAUSE I THINK IT'S SO

997
00:45:48,666 --> 00:45:50,601
IMPORTANT THAT WE --

998
00:45:50,601 --> 00:45:51,168
>> THANKS.

999
00:45:51,168 --> 00:45:54,371
I CERTAINLY HOPE AS THE AACI

1000
00:45:54,371 --> 00:45:57,308
MEETING THAT I WILL BE ABLE TO

1001
00:45:57,308 --> 00:45:58,776
TALK IN MORE CONCRETE TERMS

1002
00:45:58,776 --> 00:46:00,978
ABOUT HOW TO DO THINGS.

1003
00:46:00,978 --> 00:46:04,715
ONE OF THE REALLY IMPORTANT

1004
00:46:04,715 --> 00:46:08,185
DIFFERENCES BETWEEN WHAT THE NCI

1005
00:46:08,185 --> 00:46:10,821
DOES AND WHAT THE CANCER CENTERS

1006
00:46:10,821 --> 00:46:13,557
DO IS THAT NCI IS A RESEARCH

1007
00:46:13,557 --> 00:46:15,559
ORGANIZATION.

1008
00:46:15,559 --> 00:46:18,195
AND WE SUPPORT THE RESEARCH THAT

1009
00:46:18,195 --> 00:46:20,431
IS CONDUCTED AT THE CANCER

1010
00:46:20,431 --> 00:46:20,831
CENTERS.

1011
00:46:20,831 --> 00:46:25,536
BUT THE CANCER CENTERS ALSO ARE

1012
00:46:25,536 --> 00:46:26,503
HEALTH CARE DELIVERY

1013
00:46:26,503 --> 00:46:27,338
ORGANIZATIONS.

1014
00:46:27,338 --> 00:46:31,976
AND THEY ACTUALLY HAVE THE

1015
00:46:31,976 --> 00:46:33,344
OPPORTUNITIES TO GO BEYOND THE

1016
00:46:33,344 --> 00:46:37,314
RESEARCH SO THAT THEY PUT INTO

1017
00:46:37,314 --> 00:46:40,284
PRACTICE WHAT THE RESEARCH IS

1018
00:46:40,284 --> 00:46:41,252
SHOWING.

1019
00:46:41,252 --> 00:46:46,490
AND MY HOPE IS THAT WE WILL BE

1020
00:46:46,490 --> 00:46:48,659
ABLE NOT JUST WITH THE NCI

1021
00:46:48,659 --> 00:46:50,261
SUPPORTED CANCER RESEARCH

1022
00:46:50,261 --> 00:46:52,296
BECAUSE WE'RE DOING REASONABLY

1023
00:46:52,296 --> 00:46:54,031
WELL WITH THAT BUT THERE IS A

1024
00:46:54,031 --> 00:46:56,233
LOT OF OTHER RESEARCH THAT IS

1025
00:46:56,233 --> 00:46:59,103
CONDUCTED BY THE CANCER CENTERS.

1026
00:46:59,103 --> 00:47:02,373
IT IS NOT DIRECTLY SUPPORTED BY

1027
00:47:02,373 --> 00:47:03,107
N CONTRADICTION AND MY HOPE IS

1028
00:47:03,107 --> 00:47:07,745
THAT WE MAY BE ABLE TO HELP *

1029
00:47:07,745 --> 00:47:09,747
PROVIDE SOME RESOURCES TO ENABLE

1030
00:47:09,747 --> 00:47:14,051
WHAT YOU'RE TALKING ABOUT, JEN.

1031
00:47:14,051 --> 00:47:15,185
THANK YOU.

1032
00:47:15,185 --> 00:47:15,719
>> YES.

1033
00:47:15,719 --> 00:47:22,559
THANK YOU, DR. LOWY.

1034
00:47:22,559 --> 00:47:29,233
>> HI, KRISTEN SANTIAGO.

1035
00:47:29,233 --> 00:47:33,570
GLAD THAT YOU'RE BACK.

1036
00:47:33,570 --> 00:47:37,174
EVERYTHING THAT YOU SAID IS IN

1037
00:47:37,174 --> 00:47:41,312
ALIGNMENT AND TRYING TO FIGURE

1038
00:47:41,312 --> 00:47:41,946
THINGS OUT.

1039
00:47:41,946 --> 00:47:44,548
I HAVE A NAIVE QUESTION WHICH I

1040
00:47:44,548 --> 00:47:46,517
CAN PROBABLY GOOGLE SO IF YOU

1041
00:47:46,517 --> 00:47:49,954
JUST WANT TO TELL ME GOOGLE IT.

1042
00:47:49,954 --> 00:47:52,256
>> I CANNOT IMAGINE THAT
YOU'RE

1043
00:47:52,256 --> 00:47:56,627
GOING TO HAVE A NAIVE QUESTION.

1044
00:47:56,627 --> 00:47:58,362
>> PREPARE YOURSELF.

1045
00:47:58,362 --> 00:48:01,966
I'M CURIOUS WHY DEATH RATES HAVE

1046
00:48:01,966 --> 00:48:05,803
INCREASED.

1047
00:48:05,803 --> 00:48:07,438
>> THE SHORT ANSWER IS WE
DON'T

1048
00:48:07,438 --> 00:48:09,807
KNOW.

1049
00:48:09,807 --> 00:48:12,643
AND I DON'T THINK THAT WE HAVE

1050
00:48:12,643 --> 00:48:14,445
-- I THINK THAT WE HAVE NOT BEEN

1051
00:48:14,445 --> 00:48:18,882
AWARE OF THIS -- AS -- IT HAS

1052
00:48:18,882 --> 00:48:21,385
NOT BEEN ON THE RADAR SCREEN THE

1053
00:48:21,385 --> 00:48:22,920
WAY IT SHOULD HAVE BEEN.

1054
00:48:22,920 --> 00:48:29,593
BUT YOU KNOW -- THE MORTALITY

1055
00:48:29,593 --> 00:48:32,329
RATE PROBLEM -- WAS JUST CALLED

1056
00:48:32,329 --> 00:48:35,099
TO OUR ATTENTION LAST MONTH.

1057
00:48:35,099 --> 00:48:41,472
IT WAS NOT CLEAR UNTIL THIS

1058
00:48:41,472 --> 00:48:42,406
PAPER CAME OUT.

1059
00:48:42,406 --> 00:48:44,742
AND PREVIOUSLY THE RECOGNITION

1060
00:48:44,742 --> 00:48:46,744
THAT AFRICAN-AMERICAN WOMEN WERE

1061
00:48:46,744 --> 00:48:50,714
AT INCREASED RISK WAS KNOWN.

1062
00:48:50,714 --> 00:48:56,520
BUT THE INCREASE AMONG HISPANIC

1063
00:48:56,520 --> 00:49:01,892
WOMEN IS QUITE RECENT.

1064
00:49:01,892 --> 00:49:04,495
AND WE'RE HONESTLY NOT SURE.

1065
00:49:04,495 --> 00:49:07,598
WHAT I'M THINKING ABOUTUT

1066
00:49:07,598 --> 00:49:13,203
WE REALLY NEED TO INPUT FROM A

1067
00:49:13,203 --> 00:49:18,542
LOT OF PEOPLE IS DOING A TCGA

1068
00:49:18,542 --> 00:49:19,643
LIKE -- RESEARCH PROGRAM.

1069
00:49:19,643 --> 00:49:26,984
SO THAT WE LOOK AT DIFFERENT

1070
00:49:26,984 --> 00:49:28,852
COMMUNITIES, HISPANIC,

1071
00:49:28,852 --> 00:49:31,655
AFRICAN-AMERICAN AND OTHER WOMEN

1072
00:49:31,655 --> 00:49:35,926
SO THAT WE HAVE DETAILED

1073
00:49:35,926 --> 00:49:39,696
CHARACTERIZATION OF THEIR

1074
00:49:39,696 --> 00:49:41,198
MOLECULAR ABNORMALITIES.

1075
00:49:41,198 --> 00:49:42,699
ANOTHER THING THAT YOU MAY OR

1076
00:49:42,699 --> 00:49:46,770
MAY NOT HAVE HEARD ABOUT --

1077
00:49:46,770 --> 00:49:49,773
OFTEN REFERRED TO AS MOLECULAR

1078
00:49:49,773 --> 00:49:50,574
SIGNATURES.

1079
00:49:50,574 --> 00:49:53,310
THEY CAN IDENTIFY ACTUAL

1080
00:49:53,310 --> 00:49:55,479
ENVIRONMENTAL EXPOSURES.

1081
00:49:55,479 --> 00:49:57,481
SO WE WANT TO MAKE SURE THAT

1082
00:49:57,481 --> 00:49:59,783
THERE IS NOT SOME KIND OF

1083
00:49:59,783 --> 00:50:02,453
OBVIOUS ENVIRONMENTAL EXPOSURE

1084
00:50:02,453 --> 00:50:05,689
THAT THESE WOMEN ARE

1085
00:50:05,689 --> 00:50:08,659
INADVERTENTLY HAVING THAT MAY BE

1086
00:50:08,659 --> 00:50:12,329
LEADING TO IT.

1087
00:50:12,329 --> 00:50:15,332
AND WE NEED REALLY GOOD

1088
00:50:15,332 --> 00:50:16,767
EPIDEMIOLOGICAL EVALUATIONS AS

1089
00:50:16,767 --> 00:50:18,302
WELL.

1090
00:50:18,302 --> 00:50:21,672
IF I HAVE NOT TOTALLY BORED YOU

1091
00:50:21,672 --> 00:50:25,142
LET ME SAY THAT THIS IS NOT HAD

1092
00:50:25,142 --> 00:50:28,479
THE KIND OF ENDOMETRIAL CANCER

1093
00:50:28,479 --> 00:50:32,950
WHERE WE'VE MADE PROGRESS.

1094
00:50:32,950 --> 00:50:34,985
THE ENDOMETRIAL CANCER

1095
00:50:34,985 --> 00:50:39,490
ASSOCIATED WITH OBESITY AND THE

1096
00:50:39,490 --> 00:50:41,959
TREATMENT WITH IMMUNE CHECKPOINT

1097
00:50:41,959 --> 00:50:43,861
INHIBITORS THAT IS A DIFFERENT

1098
00:50:43,861 --> 00:50:46,330
KIND OF ENDOMETRIAL CANCER.

1099
00:50:46,330 --> 00:50:49,766
SO WE REALLY NEED TO UNDERSTAND

1100
00:50:49,766 --> 00:50:51,768
THIS OTHER FORM MUCH, MUCH

1101
00:50:51,768 --> 00:50:54,905
BETTER.

1102
00:50:54,905 --> 00:50:56,006
>> THANK YOU.

1103
00:50:56,006 --> 00:50:58,942
SO GOOGLE WON'T HELP ME.

1104
00:50:58,942 --> 00:51:00,577
>> MAYBE IT WILL.

1105
00:51:00,577 --> 00:51:02,913
I MUST CONFESS, I HAVE NOT

1106
00:51:02,913 --> 00:51:04,748
LOOKED AT THE UNIVERSITY OF

1107
00:51:04,748 --> 00:51:07,217
GOOGLE ON THIS PARTICULAR

1108
00:51:07,217 --> 00:51:07,484
QUESTION.

1109
00:51:07,484 --> 00:51:10,020
>> THANK YOU.

1110
00:51:10,020 --> 00:51:12,256
>> ANNIE.

1111
00:51:12,256 --> 00:51:14,591
>> JUST I'M GLAD YOU ASKED
THAT

1112
00:51:14,591 --> 00:51:16,660
KRISTEN BECAUSE IT'S AN ISSUE

1113
00:51:16,660 --> 00:51:19,329
THAT WE'VE BEEN ASKING ON THE

1114
00:51:19,329 --> 00:51:24,935
STEERING COMMITTEE FOR OVER --

1115
00:51:24,935 --> 00:51:27,437
BLACK PARTICIPANTS BECAUSE MY

1116
00:51:27,437 --> 00:51:30,774
FORMER COLLEAGUE -- DOUG -- ON

1117
00:51:30,774 --> 00:51:32,843
THE STEERING COMMITTEE NOTICED

1118
00:51:32,843 --> 00:51:36,079
THERE WAS A MORTALITY DISPARITY.

1119
00:51:36,079 --> 00:51:38,582
AND I WOULD REALLY -- IT'S

1120
00:51:38,582 --> 00:51:40,250
IMPORTANT THAT WE SERVE PEOPLE

1121
00:51:40,250 --> 00:51:42,085
WHO ARE NOT BENEFITING FROM THE

1122
00:51:42,085 --> 00:51:42,819
RESEARCH.

1123
00:51:42,819 --> 00:51:45,923
BUT I WANTED DR. LOWY -- THANK

1124
00:51:45,923 --> 00:51:48,125
YOU SO MUCH FOR YOUR WONDERFUL

1125
00:51:48,125 --> 00:51:50,127
PRESENTATION.

1126
00:51:50,127 --> 00:51:52,529
I WANT TO LET YOU KNOW THAT WHEN

1127
00:51:52,529 --> 00:51:55,098
I'M MENTORING A NEW RESEARCH

1128
00:51:55,098 --> 00:51:57,868
ADVOCATE THE FIRST THING I POINT

1129
00:51:57,868 --> 00:52:00,571
TO IS YOUR QUOTE ON THE

1130
00:52:00,571 --> 00:52:03,173
IMPORTANCE OF HAVING PATIENT

1131
00:52:03,173 --> 00:52:05,108
ADVOCATES AND IT REALLY

1132
00:52:05,108 --> 00:52:06,276
ENCOURAGES PEOPLE TO GET

1133
00:52:06,276 --> 00:52:06,843
INVOLVED.

1134
00:52:06,843 --> 00:52:10,380
MY QUESTION TO YOU IS AS WE KNOW

1135
00:52:10,380 --> 00:52:13,150
THAT WHEN MOONSHOTS WAS FIRST

1136
00:52:13,150 --> 00:52:14,851
LAUNCHED THERE WAS DISCUSSIONS

1137
00:52:14,851 --> 00:52:16,653
AND ROUNDTABLES AND PATIENT

1138
00:52:16,653 --> 00:52:17,654
ADVOCATES WERE INVOLVED.

1139
00:52:17,654 --> 00:52:21,925
I WOULD LIKE TO HEAR ABOUT YOUR

1140
00:52:21,925 --> 00:52:24,228
PLANS TO INVOLVE PATIENT ADD

1141
00:52:24,228 --> 00:52:28,665
VOTE INDICATES IN THE REBOOT.

1142
00:52:28,665 --> 00:52:31,235
>> MY FEELING ABOUT THIS
IS THAT

1143
00:52:31,235 --> 00:52:34,771
THERE IS A LOT OF MANY PEOPLE

1144
00:52:34,771 --> 00:52:42,679
WHO ARE TALKING WITH DANIEL --

1145
00:52:42,679 --> 00:52:44,414
-- THE PRESIDENT HAS DESIGNATED

1146
00:52:44,414 --> 00:52:47,618
TO BE THE POINT PERSON IN THE

1147
00:52:47,618 --> 00:52:49,886
OFFICE OF SCIENCE AND

1148
00:52:49,886 --> 00:52:50,454
TECHNOLOGY.

1149
00:52:50,454 --> 00:52:53,323
AND I KNOW AT LEAST SOME

1150
00:52:53,323 --> 00:52:54,625
ADVOCATES HAVE BEEN INVOLVED IN

1151
00:52:54,625 --> 00:52:56,260
DOING THAT.

1152
00:52:56,260 --> 00:52:58,695
I WOULD BE VERY HAPPY AT OUR

1153
00:52:58,695 --> 00:53:04,835
NEXT MEETING TO HAVE THAT BE A

1154
00:53:04,835 --> 00:53:05,569
SUBJECT.

1155
00:53:05,569 --> 00:53:08,338
JUST SO YOU UNDERSTAND WHAT

1156
00:53:08,338 --> 00:53:13,844
WE'RE TRYING TO DO IS -- ON THE

1157
00:53:13,844 --> 00:53:18,148
ONE HAND BE COGNIZANT OF WHAT

1158
00:53:18,148 --> 00:53:20,117
THE WHITE HOUSE WANTS TO DO FOR

1159
00:53:20,117 --> 00:53:21,752
THE NEXT PHASE OF THE CANCER

1160
00:53:21,752 --> 00:53:22,986
MOONSHOT.

1161
00:53:22,986 --> 00:53:28,625
BUT TO TRY TO MAKE IT AS BROAD

1162
00:53:28,625 --> 00:53:29,326
AS POSSIBLE.

1163
00:53:29,326 --> 00:53:32,629
I THINK THEY HAVE NOT BEEN

1164
00:53:32,629 --> 00:53:36,667
PARTICULARLY EXCITED ABOUT

1165
00:53:36,667 --> 00:53:40,103
BRINGING -- IN BASIC RESEARCH IN

1166
00:53:40,103 --> 00:53:42,606
PART BECAUSE THE HORIZON LINE

1167
00:53:42,606 --> 00:53:45,342
FOR BASIC RESEARCH IS RELATIVELY

1168
00:53:45,342 --> 00:53:46,376
SPEAKING SO LONG.

1169
00:53:46,376 --> 00:53:53,450
BUT I'M LOOKING FORWARD TO

1170
00:53:53,450 --> 00:53:55,152
ESSENTIALLY BEING ABLE TO TALK

1171
00:53:55,152 --> 00:53:56,720
WITH PEOPLE ABOUT THE

1172
00:53:56,720 --> 00:53:58,755
INTEGRATION IF YOU WILL OF THE

1173
00:53:58,755 --> 00:54:02,826
NEW PHASE OF THE CANCER MOONSHOT

1174
00:54:02,826 --> 00:54:04,628
CONTINUING THE CURRENT PHASE OF

1175
00:54:04,628 --> 00:54:06,396
THE CANCER MOONSHOT BUT HOW

1176
00:54:06,396 --> 00:54:10,467
INTEGRATED ALL OF THAT IS WITH

1177
00:54:10,467 --> 00:54:13,470
THE REST OF THE NCI BUDGET.

1178
00:54:13,470 --> 00:54:16,106
OKAY AND WE CAN PUT SOME

1179
00:54:16,106 --> 00:54:17,474
SPECIFICITY THERE.

1180
00:54:17,474 --> 00:54:21,778
IN THE FUTURE IF YOU WANT.

1181
00:54:21,778 --> 00:54:25,482
>> THANK YOU SO MUCH.

1182
00:54:25,482 --> 00:54:26,817
KEVIN.

1183
00:54:26,817 --> 00:54:28,685
>> THANKS SO MUCH DR. LOWY
FOR

1184
00:54:28,685 --> 00:54:30,153
YOUR PRESENTATION TODAY.

1185
00:54:30,153 --> 00:54:34,624
I THOROUGHLY ENJOYED THE

1186
00:54:34,624 --> 00:54:35,058
ADVANCEMENTS.

1187
00:54:35,058 --> 00:54:36,560
SOMETIMES AT THE COMMITTEE WE

1188
00:54:36,560 --> 00:54:38,628
GET IDEAS AND THINGS THAT ARE

1189
00:54:38,628 --> 00:54:40,864
PROPOSED BUT WE DON'T SEE THE

1190
00:54:40,864 --> 00:54:43,567
TRACTION AND HOW IT STARTS TO

1191
00:54:43,567 --> 00:54:46,002
GET IMPLEMENTED SO I THANK YOU

1192
00:54:46,002 --> 00:54:53,143
FOR THAT UPDATE.  A QUESTION OR

1193
00:54:53,143 --> 00:54:56,580
TWO ON ARPA.

1194
00:54:56,580 --> 00:54:58,849
AND IN READING THE REVIEW ON THE

1195
00:54:58,849 --> 00:55:00,751
ON THE LEGISLATIVE STAND POINT. 

1196
00:55:00,751 --> 00:55:03,920
THEY HAVE YET TO DECIDE WHETHER

1197
00:55:03,920 --> 00:55:05,589
THEY WANT TO HOUSE THAT.

1198
00:55:05,589 --> 00:55:07,491
ONE OF MY QUESTIONS IS I KNOW

1199
00:55:07,491 --> 00:55:09,493
THEY ARE FUNDING THIS BUT MOVING

1200
00:55:09,493 --> 00:55:12,929
FORWARD IS THERE A GREAT DELAY

1201
00:55:12,929 --> 00:55:14,698
THAT IS TAKING PLACE ON THE

1202
00:55:14,698 --> 00:55:16,400
HOUSING DECISION OF WHERE IT'S

1203
00:55:16,400 --> 00:55:19,603
GOING TO END UP AND HOW FAR AWAY

1204
00:55:19,603 --> 00:55:21,805
ARE WE GREAT GETTING

1205
00:55:21,805 --> 00:55:22,606
IMPLEMENTATION INTO THAT

1206
00:55:22,606 --> 00:55:23,573
PROGRAM?

1207
00:55:23,573 --> 00:55:27,110
>> HOLLY CAN BE MORE

1208
00:55:27,110 --> 00:55:30,313
AUTHORITATIVE THAN ME.

1209
00:55:30,313 --> 00:55:31,915
BUT WHAT HAS HAPPENED IS THAT

1210
00:55:31,915 --> 00:55:34,484
THERE IS AN APPROPRIATION BUT

1211
00:55:34,484 --> 00:55:37,621
THERE IS NOT AN AUTHORIZATION.

1212
00:55:37,621 --> 00:55:42,092
USUALLY THE AUTHORIZATION COMES

1213
00:55:42,092 --> 00:55:44,494
FIRST AND THEM THE

1214
00:55:44,494 --> 00:55:45,328
APPROPRIATION.

1215
00:55:45,328 --> 00:55:49,299
SO FOR FY22 THERE WAS A BILLION

1216
00:55:49,299 --> 00:55:51,935
DOLLARS BUT IT CAN BE --

1217
00:55:51,935 --> 00:55:53,036
INVESTED OVER A THREE-YEAR

1218
00:55:53,036 --> 00:55:57,274
PERIOD.

1219
00:55:57,274 --> 00:55:59,476
AND THE ADMINISTRATION PROPOSAL

1220
00:55:59,476 --> 00:56:04,681
WAS FOR MORE THAN $4 BILLION FOR

1221
00:56:04,681 --> 00:56:08,919
FY23 AND THE HOUSE MARK HOLLY

1222
00:56:08,919 --> 00:56:14,291
CAN CORRECT ME IS $2.3 BILLION

1223
00:56:14,291 --> 00:56:16,393
AND WE NEED TO SEE WHAT THE

1224
00:56:16,393 --> 00:56:18,428
SENATE IS GOING TO DO.

1225
00:56:18,428 --> 00:56:20,430
IT MIGHT BE INSTRUCTIVE AT THE

1226
00:56:20,430 --> 00:56:25,802
HEARING WHERE I WAS -- BOTH

1227
00:56:25,802 --> 00:56:29,239
CHAIR * DELORO AND RANKING

1228
00:56:29,239 --> 00:56:36,279
MEMBER COLE SAID THE SAME THING.

1229
00:56:36,279 --> 00:56:38,515
WE LIKE THE IDEA OF ARPA-H BUT

1230
00:56:38,515 --> 00:56:41,451
WE THINK THAT THE ADMINISTRATION

1231
00:56:41,451 --> 00:56:44,754
IS ASKING FOR TOO MUCH MONEY FOR

1232
00:56:44,754 --> 00:56:47,624
FY23.

1233
00:56:47,624 --> 00:56:49,860
AND IT JUST REMAINS TO BE SEEN

1234
00:56:49,860 --> 00:56:53,330
EXACTLY WHAT IS GOING TO HAPPEN

1235
00:56:53,330 --> 00:56:59,336
WITH THE AUTHORIZING

1236
00:56:59,336 --> 00:56:59,870
LEGISLATION.

1237
00:56:59,870 --> 00:57:01,738
THE OTHER QUESTION IS HOW MUCH

1238
00:57:01,738 --> 00:57:03,006
CANCER RESEARCH IS GOING TO BE

1239
00:57:03,006 --> 00:57:04,875
DONE WITH ARPA-H?

1240
00:57:04,875 --> 00:57:10,647
AND TO WHAT DEGREE WILL NCI BE

1241
00:57:10,647 --> 00:57:12,148
INVOLVED WITH THAT?

1242
00:57:12,148 --> 00:57:14,751
WE WOULD BE ENTHUSIASTIC ABOUT

1243
00:57:14,751 --> 00:57:16,987
WORKING WITH ARPA-H IN ANY

1244
00:57:16,987 --> 00:57:20,223
CANCER RESEARCH AREA THAT THEY

1245
00:57:20,223 --> 00:57:24,461
THINK IS MERITORIOUS.

1246
00:57:24,461 --> 00:57:25,929
>> THANK YOU FOR THAT
CLARITY.

1247
00:57:25,929 --> 00:57:29,799
I APPRECIATE IT.

1248
00:57:29,799 --> 00:57:33,570
>> THANK YOU, DR. LOWY.

1249
00:57:33,570 --> 00:57:35,171
I AM REALLY INTERESTED.

1250
00:57:35,171 --> 00:57:36,907
A LOT OF PEOPLE TALK ABOUT WHAT

1251
00:57:36,907 --> 00:57:38,275
MENTIONED ABOUT LEARNING FROM

1252
00:57:38,275 --> 00:57:40,744
THE PANDEMIC EXPERIENCE ABOUT

1253
00:57:40,744 --> 00:57:43,313
QUICKENING THE PACE OF THINGS.

1254
00:57:43,313 --> 00:57:46,683
I MENTIONED HOME EXAMS AND HOME

1255
00:57:46,683 --> 00:57:50,554
CONSENTING AND RELIANCE ON ORAL

1256
00:57:50,554 --> 00:57:51,054
OPTIONS.

1257
00:57:51,054 --> 00:57:54,791
LAST WEEK DOUG HAWKINS SPOKE AT

1258
00:57:54,791 --> 00:57:57,694
A MEETING THAT I ATTENDED AND

1259
00:57:57,694 --> 00:58:00,497
HAD SOME PRETTY INTERESTING

1260
00:58:00,497 --> 00:58:03,099
SLIDES ABOUT FOR PEDIATRIC AAL

1261
00:58:03,099 --> 00:58:06,469
PATIENTS ABOUT ADHERENT VERSUS

1262
00:58:06,469 --> 00:58:08,371
NONADHERANT OUTCOMES.

1263
00:58:08,371 --> 00:58:10,240
PATIENTS THAT ARE AT HOME TAKING

1264
00:58:10,240 --> 00:58:12,208
ORAL MEDICINE.

1265
00:58:12,208 --> 00:58:14,911
AND NOT BEING COMPLIANT IN THE

1266
00:58:14,911 --> 00:58:15,845
SCHEDULING.

1267
00:58:15,845 --> 00:58:18,648
AND I WONDER ARE WE ALSO

1268
00:58:18,648 --> 00:58:21,184
LEARNING ABOUT THAT AND HOW IF

1269
00:58:21,184 --> 00:58:25,522
WE'RE GOING TO HAVE OUR PATIENTS

1270
00:58:25,522 --> 00:58:31,561
TAKING ADVANTAGE OF LESS TIME IN

1271
00:58:31,561 --> 00:58:34,130
PATIENT AND LESS TIME IN CLINIC.

1272
00:58:34,130 --> 00:58:37,400
IS THAT DATA IMPROVING ADHERENCE

1273
00:58:37,400 --> 00:58:39,569
ALSO BEING COLLECTED?

1274
00:58:39,569 --> 00:58:43,406
>> OVER-ALL YES.

1275
00:58:43,406 --> 00:58:47,410
THE CHILDHOOD CANCER INITIATIVE

1276
00:58:47,410 --> 00:58:50,180
THE GOAL IS TO LEARN FROM EVERY

1277
00:58:50,180 --> 00:58:50,880
CHILD.

1278
00:58:50,880 --> 00:58:55,952
AND ONE OF THE THINGS I'M HOPING

1279
00:58:55,952 --> 00:58:58,922
DR. ROMAN WHEN HE JOINS WILL BE

1280
00:58:58,922 --> 00:59:00,991
ABLE TO PARTICIPATE IN IS JUST

1281
00:59:00,991 --> 00:59:02,392
THE KIND OF THINGS THAT YOU'RE

1282
00:59:02,392 --> 00:59:03,193
TALKING ABOUT.

1283
00:59:03,193 --> 00:59:05,895
BECAUSE I THINK THAT WHEN YOU

1284
00:59:05,895 --> 00:59:09,666
LOOK AT IT'S NOT JUST ADHERENCE

1285
00:59:09,666 --> 00:59:13,403
TO BEST PRACTICES BUT OUTCOMES.

1286
00:59:13,403 --> 00:59:17,173
AND WE -- AND I THINK THAT WE

1287
00:59:17,173 --> 00:59:19,476
NEED WHEN WE RECOGNIZE THAT

1288
00:59:19,476 --> 00:59:21,378
OUTCOMES ARE NOT AS GOOD WITH

1289
00:59:21,378 --> 00:59:23,947
ONE SET OF REGIMENS VERSUS

1290
00:59:23,947 --> 00:59:26,316
ANOTHER WE NEED TO CALL THAT TO

1291
00:59:26,316 --> 00:59:31,087
THE ATTENTION OF THE PEDIATRIC

1292
00:59:31,087 --> 00:59:32,856
ONCOLOGY COMMUNITY.

1293
00:59:32,856 --> 00:59:35,091
SO THE SHORT ANSWER IS YES.

1294
00:59:35,091 --> 00:59:37,027
THIS IS A REAL ISSUE.

1295
00:59:37,027 --> 00:59:44,100
IT'S A VERY IMPORTANT ONE.

1296
00:59:44,100 --> 00:59:46,636
>> I WANT TO ASK A
QUESTION --

1297
00:59:46,636 --> 00:59:48,304
NOW THAT WE'VE LEARNED FROM THE

1298
00:59:48,304 --> 00:59:51,174
PANDEMIC AND SORT OF LOOSENING

1299
00:59:51,174 --> 00:59:52,942
THE CLINICAL TRIAL DESIGNS.

1300
00:59:52,942 --> 00:59:56,046
I WAS ON A RECENT COMMITTEE AND

1301
00:59:56,046 --> 00:59:58,982
THERE IS STILL DEBATE ON WHAT

1302
00:59:58,982 --> 01:00:02,552
CAN BE LOOSENED AND WHAT

1303
01:00:02,552 --> 01:00:04,354
COMMITTEES ARE ABLE TO DO.

1304
01:00:04,354 --> 01:00:09,292
ONE STUDY IS ADHERENCE OR

1305
01:00:09,292 --> 01:00:12,095
ACCRUAL TO THAT CLINICAL TRIAL

1306
01:00:12,095 --> 01:00:14,164
-- PATIENTS NEED TO STAY AT HOME

1307
01:00:14,164 --> 01:00:18,068
FOR SOME OF IT AND SO HOW ARE WE

1308
01:00:18,068 --> 01:00:19,436
GOING TO CLARIFY THIS?

1309
01:00:19,436 --> 01:00:20,937
BECAUSE IT'S IMPORTANT AS WE

1310
01:00:20,937 --> 01:00:24,040
START TALKING ABOUT MOONSHOT

1311
01:00:24,040 --> 01:00:24,941
GOALS AND SUPPORTING THE

1312
01:00:24,941 --> 01:00:27,777
MOONSHOT AND THOSE ADDITIONAL

1313
01:00:27,777 --> 01:00:30,914
WORK THAT NCI IS DOING HOW CAN

1314
01:00:30,914 --> 01:00:34,451
WE HELP CLARIFY THAT FOR OUR

1315
01:00:34,451 --> 01:00:36,086
RESEARCH SCIENTISTS THAT ARE

1316
01:00:36,086 --> 01:00:37,353
PUTTING IN FOR CLINICAL TRIALS

1317
01:00:37,353 --> 01:00:38,321
RIGHT NOW?

1318
01:00:38,321 --> 01:00:44,594
>> I THINK THAT CALLING
THAT TO

1319
01:00:44,594 --> 01:00:49,933
OUR ATTENTION IS VERY IMPORTANT.

1320
01:00:49,933 --> 01:00:52,869
ON SOME LEVEL WE ARE BOUND BY

1321
01:00:52,869 --> 01:00:54,704
REGULATORY ISSUES.

1322
01:00:54,704 --> 01:01:00,477
ON THE OTHER HAND THE FDA --

1323
01:01:00,477 --> 01:01:02,312
CERTAINLY RECOGNIZES THAT WE

1324
01:01:02,312 --> 01:01:04,714
NEED TO INSTITUTE SOME CHANGES.

1325
01:01:04,714 --> 01:01:06,883
SO IF THERE ARE SPECIFIC ISSUES

1326
01:01:06,883 --> 01:01:09,919
THAT YOU THINK ARE GOING TO --

1327
01:01:09,919 --> 01:01:13,556
COULD REALLY HELP OPEN THINGS UP

1328
01:01:13,556 --> 01:01:16,292
-- I WOULD SUGGEST -- BRING THEM

1329
01:01:16,292 --> 01:01:20,830
TO OUR ATTENTION EITHER THROUGH

1330
01:01:20,830 --> 01:01:24,667
AMY -- YOU CAN SEND ME AN E-MAIL

1331
01:01:24,667 --> 01:01:32,375
-- WE WILL LOOK AT THEM.

1332
01:01:32,375 --> 01:01:33,910
THE DIFFICULT WE TRY TO DO

1333
01:01:33,910 --> 01:01:36,045
IMMEDIATELY.

1334
01:01:36,045 --> 01:01:38,882
THE IMPOSSIBLE TAKES A LITTLE

1335
01:01:38,882 --> 01:01:39,282
LONGER.

1336
01:01:39,282 --> 01:01:40,416
>> I APPRECIATE THAT.

1337
01:01:40,416 --> 01:01:43,586
EVEN IF IT'S A LITTLE -- PATIENT

1338
01:01:43,586 --> 01:01:44,921
QUESTIONS DO STANDARD OF CARE AT

1339
01:01:44,921 --> 01:01:47,323
HOME THAT WOULD BE WONDERFUL AND

1340
01:01:47,323 --> 01:01:51,361
IF THAT WAS ALL WE WERE ABLE TO

1341
01:01:51,361 --> 01:01:52,662
ACCOMPLISH --

1342
01:01:52,662 --> 01:01:54,664
>> THERE IS ALWAYS THE
DYNAMIC

1343
01:01:54,664 --> 01:01:57,333
TENSE -- IF WE DO IT AT HOME IS

1344
01:01:57,333 --> 01:01:59,202
THIS GOING TO BE SUBSTANDARD?

1345
01:01:59,202 --> 01:02:03,306
SO WE NEED TO PAY ATTENTION TO

1346
01:02:03,306 --> 01:02:08,211
QUALITY IN ADDITION TO LOCATION.

1347
01:02:08,211 --> 01:02:09,946
>> THANK YOU FOR THAT.

1348
01:02:09,946 --> 01:02:13,349
JACQUELYN.

1349
01:02:13,349 --> 01:02:13,817
>> HI.

1350
01:02:13,817 --> 01:02:14,350
YES.

1351
01:02:14,350 --> 01:02:16,419
THIS IS PIGGYBACKING.

1352
01:02:16,419 --> 01:02:20,757
I WAS THINKING ABOUT BACK IN

1353
01:02:20,757 --> 01:02:23,493
2007 WHEN I WAS ON MY CLINICAL

1354
01:02:23,493 --> 01:02:25,562
TRIAL AT MOFFETT EVERY MONTH I

1355
01:02:25,562 --> 01:02:28,798
WOULD HAVE TO DRY OUT THERE FOR

1356
01:02:28,798 --> 01:02:30,600
BLOOD DRAWS FOR THE FIRST WEEK

1357
01:02:30,600 --> 01:02:32,936
OF EVERY MONTH.

1358
01:02:32,936 --> 01:02:36,105
AND I REMEMBER AN OLDER

1359
01:02:36,105 --> 01:02:37,607
GENTLEMAN SITTING NEXT TO ME

1360
01:02:37,607 --> 01:02:39,042
SAYING HE WAS NOT GOING TO BE

1361
01:02:39,042 --> 01:02:40,610
ABLE TO COMPLETE THE TRIAL

1362
01:02:40,610 --> 01:02:42,612
BECAUSE HE COULD NOT AFFORD TO

1363
01:02:42,612 --> 01:02:45,415
DRIVE THAT FAR.

1364
01:02:45,415 --> 01:02:47,650
WE WERE NOT ALLOWED TO HAVE OUR

1365
01:02:47,650 --> 01:02:49,152
DRAWING DONE AT A COMMUNITY

1366
01:02:49,152 --> 01:02:50,987
CENTER OR CLOSER TO HOME.

1367
01:02:50,987 --> 01:02:52,956
SO SOMETIMES WHEN WE LOOK AT

1368
01:02:52,956 --> 01:02:54,958
ISSUES AROUND ACCRUAL AND

1369
01:02:54,958 --> 01:02:58,194
NUTRITION AND ACCESS THERE ARE

1370
01:02:58,194 --> 01:02:59,729
PRACTICAL ISSUES ABOUT THE

1371
01:02:59,729 --> 01:03:01,397
NUMBER OF VISITS THAT PATIENTS

1372
01:03:01,397 --> 01:03:03,032
HAVE TO MAKE.

1373
01:03:03,032 --> 01:03:05,168
AND I KNOW THERE IS A LOT OF

1374
01:03:05,168 --> 01:03:10,006
TIME SPENT FOCUSED ON MYTHS

1375
01:03:10,006 --> 01:03:12,075
SURROUNDING CLINICAL TRIAL

1376
01:03:12,075 --> 01:03:12,809
PARTICIPATION.

1377
01:03:12,809 --> 01:03:14,277
AND ANOTHER QUESTION I HAVE

1378
01:03:14,277 --> 01:03:16,179
BECAUSE I NOW WORK ON THE

1379
01:03:16,179 --> 01:03:18,047
INDUSTRY SIDE AND WE'RE LOOKING

1380
01:03:18,047 --> 01:03:20,250
AT WHY ARE PEOPLE NOT ENROLLING

1381
01:03:20,250 --> 01:03:22,252
IN THE TRIALS AND SOME OF THE

1382
01:03:22,252 --> 01:03:24,721
RESEARCH IS ON THE PHYSICIAN'S

1383
01:03:24,721 --> 01:03:26,389
SIDE THERE ARE ASSUMPTIONS

1384
01:03:26,389 --> 01:03:29,359
AROUND WHO WOULD MAKE THE BEST

1385
01:03:29,359 --> 01:03:31,928
TRIAL PARTICIPANT AND COMPLIANT.

1386
01:03:31,928 --> 01:03:33,229
IS THERE ANYTHING GOING ON THAT

1387
01:03:33,229 --> 01:03:35,632
YOU KNOW OF THAT LOOKS AT

1388
01:03:35,632 --> 01:03:37,467
PHYSICIAN BIAS AND ASSUMPTIONS

1389
01:03:37,467 --> 01:03:40,103
THAT COME ALONG WITH WHO IS

1390
01:03:40,103 --> 01:03:41,237
OFFERED TRIALS BECAUSE THAT IS

1391
01:03:41,237 --> 01:03:43,172
WHAT WE'VE LEARNED IS THAT SOME

1392
01:03:43,172 --> 01:03:44,741
PATIENTS ARE NOT EVEN OFFERED

1393
01:03:44,741 --> 01:03:45,942
TRIALS?

1394
01:03:45,942 --> 01:03:48,578
>> YOU'RE BRINGING UP A
REALLY

1395
01:03:48,578 --> 01:03:49,078
IMPORTANT ISSUE.

1396
01:03:49,078 --> 01:03:53,850
MOST OF OUR FOCUS HAS BEEN WITH

1397
01:03:53,850 --> 01:03:57,687
NCI SPONSORED TRIALS AND I THINK

1398
01:03:57,687 --> 01:04:00,690
THAT THIS IS AN ISSUE THAT I

1399
01:04:00,690 --> 01:04:01,991
THINK THAT HAS BEEN LARGELY

1400
01:04:01,991 --> 01:04:04,093
OVERCOME.

1401
01:04:04,093 --> 01:04:06,429
BUT IT'S NOT BEEN OVERCOME IN

1402
01:04:06,429 --> 01:04:09,899
MANY OTHER AREAS AND IMPLICIT

1403
01:04:09,899 --> 01:04:13,736
BIAS OR EXPLICIT BIAS ARE THINGS

1404
01:04:13,736 --> 01:04:15,705
THAT ARE TERRIBLY IMPORTANT THAT

1405
01:04:15,705 --> 01:04:18,574
WE NEED TO THINK ABOUT.

1406
01:04:18,574 --> 01:04:20,476
AND YOUR FIRST POINT IS

1407
01:04:20,476 --> 01:04:29,852
ABSOLUTELY ON TARGET.

1408
01:04:29,852 --> 01:04:32,722
ABOUT 10 YEARS AGO A RELATIVE OF

1409
01:04:32,722 --> 01:04:35,224
MINE HAD PANCREATIC CANCER AND

1410
01:04:35,224 --> 01:04:36,759
HE WAS VERY INTERESTED IN

1411
01:04:36,759 --> 01:04:38,962
PARTICIPATING IN THE RESEARCH.

1412
01:04:38,962 --> 01:04:42,632
BUT HE SAID THERE ARE TOO MANY

1413
01:04:42,632 --> 01:04:44,400
VISITS.

1414
01:04:44,400 --> 01:04:47,770
AND IT'S NOT LIKELY THAT I AM

1415
01:04:47,770 --> 01:04:49,539
GOING TO BE CURED.

1416
01:04:49,539 --> 01:04:51,407
AND THAT IS NOT HOW I WANT TO

1417
01:04:51,407 --> 01:04:57,213
SPEND MY REMAINING TIME.

1418
01:04:57,213 --> 01:05:03,152
THIS WAS A MAN WITH A -- HE WAS.

1419
01:05:03,152 --> 01:05:04,821
HE UNDERSTOOD WHAT WAS HAPPENING

1420
01:05:04,821 --> 01:05:08,391
AND HE WANTED TO PARTICIPATE.

1421
01:05:08,391 --> 01:05:10,927
SO WHAT SAY IN TERMS OF THE

1422
01:05:10,927 --> 01:05:13,429
PRACTICAL ASPECTS REALLY

1423
01:05:13,429 --> 01:05:17,400
RESONATES.

1424
01:05:17,400 --> 01:05:18,401
>> DO WE HAVE ANY MORE

1425
01:05:18,401 --> 01:05:22,271
QUESTIONS?

1426
01:05:22,271 --> 01:05:24,507
IF NOT I WANT TO THANK YOU FOR

1427
01:05:24,507 --> 01:05:26,909
YOUR UPDATE AND ANSWERING OUR

1428
01:05:26,909 --> 01:05:28,578
QUESTIONS AND LISTENING TO OUR

1429
01:05:28,578 --> 01:05:32,248
VIEWS ON WHAT WE CAN DO AROUND

1430
01:05:32,248 --> 01:05:33,916
CLINICAL TRIALS.

1431
01:05:33,916 --> 01:05:36,119
BUT NEXT I BELIEVE AMY DO YOU

1432
01:05:36,119 --> 01:05:39,122
WANT TO TAKE THE BREAK OR DO YOU

1433
01:05:39,122 --> 01:05:40,423
WANT TO MOVE TO THE NEXT

1434
01:05:40,423 --> 01:05:45,695
SESSION?

1435
01:05:45,695 --> 01:05:47,730
>> I WILL DEFER TO YOU.

1436
01:05:47,730 --> 01:05:51,167
I KNOW THAT DR. CASTLE IS HERE.

1437
01:05:51,167 --> 01:05:52,001
>> OKAY.

1438
01:05:52,001 --> 01:05:54,003
I GUESS MAYBE WE'LL GET STARTED

1439
01:05:54,003 --> 01:05:55,571
IF THAT IS OKAY.

1440
01:05:55,571 --> 01:05:57,240
>> THAT SOUNDS GREAT AND
IF WE

1441
01:05:57,240 --> 01:05:58,808
HAVE TIME BETWEEN THE NEXT

1442
01:05:58,808 --> 01:06:01,044
SESSION I'LL GIVE EVERYONE A

1443
01:06:01,044 --> 01:06:01,978
SHORT BREAK.

1444
01:06:01,978 --> 01:06:04,981
>> I DIDN'T SEE DR. CASTLE
HAD

1445
01:06:04,981 --> 01:06:07,050
JOINED SO, THAT IS PERFECT

1446
01:06:07,050 --> 01:06:07,283
TIMING.

1447
01:06:07,283 --> 01:06:10,353
I WANT TO THANK DR. CASTLE.

1448
01:06:10,353 --> 01:06:15,725
AND LOOK FORWARD TO YOUR

1449
01:06:15,725 --> 01:06:16,559
PRESENTATION.

1450
01:06:16,559 --> 01:06:21,030
>> CAN YOU HEAR ME?

1451
01:06:21,030 --> 01:06:21,297
>> YES.

1452
01:06:21,297 --> 01:06:21,731
>> GOOD.

1453
01:06:21,731 --> 01:06:28,438
THAT IS PROGRESS.

1454
01:06:28,438 --> 01:06:31,641
>> THANK YOU FOR THE
INVITATION

1455
01:06:31,641 --> 01:06:33,209
TO TALK TO YOU AND I LOOK

1456
01:06:33,209 --> 01:06:35,278
FORWARD TO THE DISCUSSION.

1457
01:06:35,278 --> 01:06:37,213
JUST ONE CAVEATS HERE.

1458
01:06:37,213 --> 01:06:39,148
YOU'RE GOING TO SEE SOME

1459
01:06:39,148 --> 01:06:40,483
COMPLICATED SLIDES AND I DON'T

1460
01:06:40,483 --> 01:06:43,886
WANT YOU TO GET TOO WORRIED.

1461
01:06:43,886 --> 01:06:52,395
I WANTED TO ILLUSTRATE THE

1462
01:06:52,395 --> 01:06:53,830
BREATH AND DEPTH OF WHAT WE'RE

1463
01:06:53,830 --> 01:06:56,099
TRYING TO DO TO PREVENT CANCER.

1464
01:06:56,099 --> 01:06:57,633
TO SEE ALL OF THE PROJECT THAT'S

1465
01:06:57,633 --> 01:06:58,401
ARE GOING ON.

1466
01:06:58,401 --> 01:07:00,837
WE'RE NOT GOING TO GET SUPER

1467
01:07:00,837 --> 01:07:01,838
TECHNICAL.

1468
01:07:01,838 --> 01:07:04,240
BUT I WANT YOU TO APPRECIATE THE

1469
01:07:04,240 --> 01:07:06,342
RESEARCH THAT THE DIVISIONS

1470
01:07:06,342 --> 01:07:08,211
SPONSORING AND SUPPORTING.

1471
01:07:08,211 --> 01:07:11,147
AND WE'RE TRYING TO GET AFTER

1472
01:07:11,147 --> 01:07:12,982
BETTER WAYS TO PREVENT CANCER.

1473
01:07:12,982 --> 01:07:14,984
SO WITH THAT CAN I HAVE THE NEXT

1474
01:07:14,984 --> 01:07:18,888
SLIDE, PLEASE.

1475
01:07:18,888 --> 01:07:21,290
I WANT TO POINT OUT THAT THESE

1476
01:07:21,290 --> 01:07:23,926
ARE MY OPINIONS AND DON'T

1477
01:07:23,926 --> 01:07:25,328
REPRESENT ANYONE ELSE'S.

1478
01:07:25,328 --> 01:07:27,363
MY COMMENTS ARE INFORMAL AND

1479
01:07:27,363 --> 01:07:29,532
SHOULD NOT BE TAKENNING  AA

1480
01:07:29,532 --> 01:07:32,735
SIGNAL OF FUNDING OPPORTUNITIES.

1481
01:07:32,735 --> 01:07:34,203
IF I MENTION SPECIFIC PRODUCTS

1482
01:07:34,203 --> 01:07:35,805
THAT IS NOT AN ENDORSEMENT AND I

1483
01:07:35,805 --> 01:07:38,474
HAVE A FEW DISCLOSURES.

1484
01:07:38,474 --> 01:07:41,410
I'VE WORKED WITH SEVERAL HPV

1485
01:07:41,410 --> 01:07:44,413
TESTING COMPANIES AND GOTTEN

1486
01:07:44,413 --> 01:07:47,483
TESTS AT REDUCED AND AT NO COST

1487
01:07:47,483 --> 01:07:50,720
FOR RESEARCH ONLY.

1488
01:07:50,720 --> 01:07:54,323
SO MR. SPOCK IS ONE OF MY

1489
01:07:54,323 --> 01:07:56,292
FAVORITE PUBLIC HEALTH

1490
01:07:56,292 --> 01:07:57,793
SCIENTISTS AND HE FOR THOSE THAT

1491
01:07:57,793 --> 01:07:59,695
ARE OLD ENOUGH TO KNOW WHAT STAR

1492
01:07:59,695 --> 01:08:00,897
TREK IS.

1493
01:08:00,897 --> 01:08:04,267
HE ONCE SAID THE NEEDS OF THE

1494
01:08:04,267 --> 01:08:07,136
MANY OUTWEIGH THE NEEDS OF THE

1495
01:08:07,136 --> 01:08:09,672
FEW AND THE ONE.

1496
01:08:09,672 --> 01:08:11,741
WHEN WE DO PREVENTION WE'RE

1497
01:08:11,741 --> 01:08:13,276
DOING PREVENTION IN A WHOLE

1498
01:08:13,276 --> 01:08:14,877
POPULATION AND WE WANT TO REACH

1499
01:08:14,877 --> 01:08:15,545
EVERYONE.

1500
01:08:15,545 --> 01:08:18,114
AND I ADDED THE POINT BELOW

1501
01:08:18,114 --> 01:08:19,882
PROVIDED THAT EVERYONE IS

1502
01:08:19,882 --> 01:08:21,184
COUNTED EQUALLY.

1503
01:08:21,184 --> 01:08:26,956
AND I THINK MR. SPOCK IS A

1504
01:08:26,956 --> 01:08:28,624
FOREIGNER ON THE STAR SHIP WOULD

1505
01:08:28,624 --> 01:08:31,127
APPRECIATE THAT ADDITION TO HIS

1506
01:08:31,127 --> 01:08:31,794
STATEMENT.

1507
01:08:31,794 --> 01:08:34,697
IS SO IN THE ONE POINT IN THE

1508
01:08:34,697 --> 01:08:35,998
TALK THAT IS GOING TO BE

1509
01:08:35,998 --> 01:08:39,735
AUDIENCE PARTICIPATION POINT --

1510
01:08:39,735 --> 01:08:40,870
DISCUSSION.

1511
01:08:40,870 --> 01:08:42,638
NEXT PLEASE.

1512
01:08:42,638 --> 01:08:45,374
SO I'M GOING TO ASK WOULD YOU

1513
01:08:45,374 --> 01:08:47,643
RATHER HAVE YOUR CANCER

1514
01:08:47,643 --> 01:08:49,378
PREVENTED OR TREATED?

1515
01:08:49,378 --> 01:08:51,981
WANT TO HAVE THEIR CAR CERTAIN

1516
01:08:51,981 --> 01:08:53,449
PREVENTED PLEASE RAISE YOUR

1517
01:08:53,449 --> 01:08:54,383
HAND.

1518
01:08:54,383 --> 01:08:56,786
AND THOSE THAT WANTED THEIR

1519
01:08:56,786 --> 01:08:57,820
CANCER TO BE TREATED.

1520
01:08:57,820 --> 01:09:01,624
YOU HAVE TO CHOOSE ONE.

1521
01:09:01,624 --> 01:09:04,293
SO NEXT PLEASE.

1522
01:09:04,293 --> 01:09:06,896
I THINK IN MY OPINION THE BEST

1523
01:09:06,896 --> 01:09:09,265
CANCER IS THE CANCER THAT NEVER

1524
01:09:09,265 --> 01:09:11,667
HAPPENS AND I THINK MOST PEOPLE

1525
01:09:11,667 --> 01:09:12,702
FEEL THAT WAY.

1526
01:09:12,702 --> 01:09:15,171
AS SOMEONE WHO HAS NOT

1527
01:09:15,171 --> 01:09:17,807
EXPERIENCED CANCER DIRECTLY BUT

1528
01:09:17,807 --> 01:09:19,909
HAS HAD MY FAMILY DEVASTATED BY

1529
01:09:19,909 --> 01:09:24,847
CANCER IT'S -- IT DESTROYS NOT

1530
01:09:24,847 --> 01:09:27,917
ONLY -- EVEN IF YOU SURVIVE IT

1531
01:09:27,917 --> 01:09:30,486
IT'S DEVASTATING TO THE PERSON,

1532
01:09:30,486 --> 01:09:32,588
THE FAMILY, TO THE COMMUNITY.

1533
01:09:32,588 --> 01:09:35,224
AND WE NEED TO DO A BETTER JOB

1534
01:09:35,224 --> 01:09:37,159
OF PREVENTING IT.

1535
01:09:37,159 --> 01:09:40,963
NEXT PLEASE.

1536
01:09:40,963 --> 01:09:43,199
ONE OF THE CHALLENGES IN DOING

1537
01:09:43,199 --> 01:09:45,768
THIS WORK AND I'M NOT SAYING WE

1538
01:09:45,768 --> 01:09:47,203
SHOULD SPEND LESS ON TREATMENT

1539
01:09:47,203 --> 01:09:49,872
IS TO GET MORE RESOURCES INTO

1540
01:09:49,872 --> 01:09:51,240
PREVENTION.

1541
01:09:51,240 --> 01:09:52,908
AND I STILL THINK THIS IS OUR

1542
01:09:52,908 --> 01:09:54,910
FIRST LINE OF DEFENSE AND I

1543
01:09:54,910 --> 01:09:56,679
THINK EVERYBODY WANTS BETTER

1544
01:09:56,679 --> 01:09:57,880
PREVENTION AND IN ORDER TO DO

1545
01:09:57,880 --> 01:09:59,315
THAT THE GOVERNMENTS GOING TO

1546
01:09:59,315 --> 01:10:01,050
HAVE TO MAKE SOME ADDITIONAL

1547
01:10:01,050 --> 01:10:01,884
INVESTMENTS.

1548
01:10:01,884 --> 01:10:05,154
MANY CANCERS WE CANNOT PREVENT

1549
01:10:05,154 --> 01:10:06,455
AT THE MOMENT.

1550
01:10:06,455 --> 01:10:08,824
I WANT TO EMPHASIZE WE NEED

1551
01:10:08,824 --> 01:10:09,191
TREATMENT.

1552
01:10:09,191 --> 01:10:10,993
I'M NOT SUGGESTING AT ALL THIS

1553
01:10:10,993 --> 01:10:12,828
WE REDUCE OUR FUNDING  IN

1554
01:10:12,828 --> 01:10:13,296
TREATMENT.

1555
01:10:13,296 --> 01:10:15,364
ONLY THAT WE SHOULD INCREASE OUR

1556
01:10:15,364 --> 01:10:17,066
FUNDING TO DEVELOP NEW WAYS TO

1557
01:10:17,066 --> 01:10:19,001
PREVENT CANCER.

1558
01:10:19,001 --> 01:10:21,971
NEXT SLIDE PLEASE.

1559
01:10:21,971 --> 01:10:24,407
AND THIS ILLUSTRATES THAT WE'VE

1560
01:10:24,407 --> 01:10:26,942
NOT MADE A LOT OF PROGRESS.

1561
01:10:26,942 --> 01:10:29,412
YOU CAN ARGUE THAT WE'VE MADE

1562
01:10:29,412 --> 01:10:31,447
VIRTUALLY NO PROGRESS IN THE

1563
01:10:31,447 --> 01:10:32,682
LAST 40 YEARS IN THE PREVENTION

1564
01:10:32,682 --> 01:10:36,519
OF CANCER.

1565
01:10:36,519 --> 01:10:38,721
WE'VE REDUCED MORTALITY AND SOME

1566
01:10:38,721 --> 01:10:41,891
HAS TO DO WITH SCREENING AND

1567
01:10:41,891 --> 01:10:44,460
TREATMENT BUT PREVENTING CANCER

1568
01:10:44,460 --> 01:10:48,564
IN THE POPULATION WE'VE NOT DONE

1569
01:10:48,564 --> 01:10:49,765
SUCH A GOOD JOB.

1570
01:10:49,765 --> 01:10:53,069
THERE WAS A BLIP HERE -- I DON'T

1571
01:10:53,069 --> 01:10:55,471
KNOW IF THAT WAS RELATED TO SOME

1572
01:10:55,471 --> 01:10:58,240
PSA OR SCREENING OR WHATNOT.

1573
01:10:58,240 --> 01:11:01,143
BUT WE'VE NOT MADE PROGRESS.

1574
01:11:01,143 --> 01:11:03,946
AND THAT IS NOT GOING TO CUT IT

1575
01:11:03,946 --> 01:11:07,249
FROM MY PERSPECTIVE.

1576
01:11:07,249 --> 01:11:09,885
THERE ARE CHALLENGES TO CANCER

1577
01:11:09,885 --> 01:11:11,454
PREVENTION.

1578
01:11:11,454 --> 01:11:13,589
THERE IS AN EVENT BIAS AND ONE

1579
01:11:13,589 --> 01:11:16,359
OF MY MOTIVATIONS IS TO GET YOUR

1580
01:11:16,359 --> 01:11:18,427
HELP IN ADVOCATING FOR BETTER

1581
01:11:18,427 --> 01:11:19,428
PREVENTION.

1582
01:11:19,428 --> 01:11:21,931
SO ONE OF THE CHALLENGES IS THAT

1583
01:11:21,931 --> 01:11:26,001
THERE IS NOTHING TO POINT AT.

1584
01:11:26,001 --> 01:11:27,703
THERE IS NO CHAMPION.

1585
01:11:27,703 --> 01:11:29,605
THERE IS NOBODY WHO SURVIVED

1586
01:11:29,605 --> 01:11:30,740
CANCER.

1587
01:11:30,740 --> 01:11:34,076
THERE IS NO CANCER SURVIVOR.

1588
01:11:34,076 --> 01:11:35,244
WE PREVENTED IT.

1589
01:11:35,244 --> 01:11:36,645
THERE IS NO EVENT.

1590
01:11:36,645 --> 01:11:40,282
THERE IS THE PREVENTION PARADOX.

1591
01:11:40,282 --> 01:11:44,286
MOST OCCUR IN THE AVERAGE RISK

1592
01:11:44,286 --> 01:11:47,156
PERSON.

1593
01:11:47,156 --> 01:11:49,392
AND OVER ARCHING MANDATE IS

1594
01:11:49,392 --> 01:11:51,527
KEEPING HEALTHY PEOPLE HEALTHY

1595
01:11:51,527 --> 01:11:55,664
AND ALTHOUGH WE IN THE FIRST DO

1596
01:11:55,664 --> 01:11:59,435
NO HARM THAT IS ASSOCIATED WITH

1597
01:11:59,435 --> 01:12:00,469
MEDICAL PRACTICE IT'S MORE

1598
01:12:00,469 --> 01:12:03,005
IMPORTANT IN THE PUBLIC HEALTH

1599
01:12:03,005 --> 01:12:05,408
ARENA BECAUSE WE PRIMARILY DEAL

1600
01:12:05,408 --> 01:12:07,143
WITH HEALTHY PEOPLE.

1601
01:12:07,143 --> 01:12:09,745
I TALK ABOUT CERVICAL CANCER --

1602
01:12:09,745 --> 01:12:13,649
WHICH IS IF WE DID NOTHING 49

1603
01:12:13,649 --> 01:12:17,420
OUT OF 50 WOMEN WOULD NEVER GET

1604
01:12:17,420 --> 01:12:18,487
CERVICAL CANCER.

1605
01:12:18,487 --> 01:12:20,656
NO SCREENING.

1606
01:12:20,656 --> 01:12:25,094
NO HPV VACCINATION 49 OUT OF THE

1607
01:12:25,094 --> 01:12:27,029
50 WOMEN WOULD BE PERFECT FINE

1608
01:12:27,029 --> 01:12:32,635
SO WHAT WE DO IN THE 49 HAS TO

1609
01:12:32,635 --> 01:12:34,370
BE TAKEN IN THE EQUAL

1610
01:12:34,370 --> 01:12:34,770
CONSIDERATION.

1611
01:12:34,770 --> 01:12:42,545
THERE IS A HIGH BAR.

1612
01:12:42,545 --> 01:12:47,483
WHO ARE WE HU -- HURTING AND

1613
01:12:47,483 --> 01:12:48,117
HELPING?

1614
01:12:48,117 --> 01:12:51,020
BECAUSE OF THAT BECAUSE WE'RE

1615
01:12:51,020 --> 01:12:53,456
DEALING WITH A HEALTHY

1616
01:12:53,456 --> 01:12:54,824
POPULATION THERE IS LITTLE

1617
01:12:54,824 --> 01:12:57,460
TOLERANCE FOR THE INTOLERABLE.

1618
01:12:57,460 --> 01:12:59,762
WE CANNOT HAVE SIDE EFFECTS.

1619
01:12:59,762 --> 01:13:01,897
AND NO MONEY IN PREVENTION AND

1620
01:13:01,897 --> 01:13:03,732
THAT IS PARTICULARLY RELATED TO

1621
01:13:03,732 --> 01:13:06,902
PHARMA AND I WANT TO CHALLENGE

1622
01:13:06,902 --> 01:13:08,170
THAT NOTION GOING FORWARD.

1623
01:13:08,170 --> 01:13:11,607
WITH THE IDEA THAT IF EVERYBODY

1624
01:13:11,607 --> 01:13:13,008
NEEDS PREVENTION THEN THERE IS

1625
01:13:13,008 --> 01:13:13,609
AN OPPORTUNITY.

1626
01:13:13,609 --> 01:13:15,444
BECAUSE THAT IS A BIG

1627
01:13:15,444 --> 01:13:15,945
DENOMINATOR.

1628
01:13:15,945 --> 01:13:17,713
A LOT OF PEOPLE NEEDING

1629
01:13:17,713 --> 01:13:18,247
PREVENTION.

1630
01:13:18,247 --> 01:13:22,418
SO MAYBE WE HAVE TO HAVE A

1631
01:13:22,418 --> 01:13:24,753
DIFFERENT MODEL FOR RESOURCING

1632
01:13:24,753 --> 01:13:25,120
THIS.

1633
01:13:25,120 --> 01:13:26,822
BUT THAT SEEMS LIKE SOME BIG

1634
01:13:26,822 --> 01:13:27,456
MONEY.

1635
01:13:27,456 --> 01:13:29,992
THERE ARE 300 MILLION PEOPLE IN

1636
01:13:29,992 --> 01:13:31,927
THE COUNTRY AND HALF OF THOSE

1637
01:13:31,927 --> 01:13:34,063
PEOPLE WILL GET CANCER.

1638
01:13:34,063 --> 01:13:36,098
THAT SEEMS LIKE A PRETTY

1639
01:13:36,098 --> 01:13:39,134
SUBSTANTIAL MARKET.

1640
01:13:39,134 --> 01:13:41,670
SO THIS IS AN OUTLINE -- I WANT

1641
01:13:41,670 --> 01:13:43,906
TO TELL YOU ABOUT MY FABULOUS

1642
01:13:43,906 --> 01:13:46,141
DIVISION OR THE DIVISION I'M

1643
01:13:46,141 --> 01:13:47,209
REPRESENTING.

1644
01:13:47,209 --> 01:13:50,546
IT'S MORE DOUG'S DIVISION BUT I

1645
01:13:50,546 --> 01:13:52,114
REPRESENT THE DIVISION OF CANCER

1646
01:13:52,114 --> 01:13:52,715
PREVENTION.

1647
01:13:52,715 --> 01:13:53,983
AND TALK ABOUT THE RESEARCH THAT

1648
01:13:53,983 --> 01:13:54,917
WE SUPPORT.

1649
01:13:54,917 --> 01:13:58,020
AND I WANT TO END WITH A LITTLE

1650
01:13:58,020 --> 01:14:00,356
DISCUSSION MULTI-CANCER EARLY

1651
01:14:00,356 --> 01:14:01,490
DETECTION BECAUSE THERE HAS BEEN

1652
01:14:01,490 --> 01:14:11,967
A LOT OF CHAIRER ABOUT THAT.

1653
01:14:12,835 --> 01:14:13,936
>> THIS IS OUR MISSION

1654
01:14:13,936 --> 01:14:19,708
STATEMENT.

1655
01:14:19,708 --> 01:14:24,246
THE NCI DIVISION LEADS AND

1656
01:14:24,246 --> 01:14:27,917
SUPPORTS AND PROMOTES RIGOROUS

1657
01:14:27,917 --> 01:14:29,518
INNOVATIVE RESEARCH AND TRAINING

1658
01:14:29,518 --> 01:14:33,289
TO REDUCE RISKS, BURDENS AND

1659
01:14:33,289 --> 01:14:35,391
CONSEQUENCES OF CANCER TO

1660
01:14:35,391 --> 01:14:37,126
IMPROVE THE HEALTH OF ALL

1661
01:14:37,126 --> 01:14:37,826
PEOPLE.

1662
01:14:37,826 --> 01:14:42,598
YOU CAN SEE THERE IS A SET OF

1663
01:14:42,598 --> 01:14:44,667
AREAS, RESEARCH GROUPS -- I'M

1664
01:14:44,667 --> 01:14:49,305
FORTUNATE TO HAVE A STRONG

1665
01:14:49,305 --> 01:14:57,279
LEADERSHIP TEAM.

1666
01:14:57,279 --> 01:15:01,016
I'M GOING TO FRAME MY DISCUSSION

1667
01:15:01,016 --> 01:15:02,585
AROUND THIS TRANSLATIONAL

1668
01:15:02,585 --> 01:15:05,120
RESEARCH CONTINUUM.

1669
01:15:05,120 --> 01:15:07,990
THE NCI DOES A LOT OF WORK FROM

1670
01:15:07,990 --> 01:15:10,326
THE BASIC SCIENCE AND I'M SURE

1671
01:15:10,326 --> 01:15:12,828
YOU HAVE HEARD FROM DCB AND

1672
01:15:12,828 --> 01:15:13,495
OTHERS.

1673
01:15:13,495 --> 01:15:20,903
ALL THE WAY TO T4:  T3 AND T4 --

1674
01:15:20,903 --> 01:15:23,439
I KNOW THAT TINA GOOD FORD HAS

1675
01:15:23,439 --> 01:15:24,940
COME TO TALK TO YOU.

1676
01:15:24,940 --> 01:15:27,109
HOW DO WE GET THIS TO

1677
01:15:27,109 --> 01:15:28,978
COMMUNITIES AND POPULATIONS?

1678
01:15:28,978 --> 01:15:39,521
WE TEND IN DCP TO FOCUS ON LATE

1679
01:15:44,159 --> 01:15:50,499
T0 TO T2.

1680
01:15:50,499 --> 01:15:55,304
AND THAT IS ILLUSTRATED HERE.

1681
01:15:55,304 --> 01:15:57,473
DCB IS THE DIVISION OF CANCER

1682
01:15:57,473 --> 01:15:59,475
BIOLOGY AND DOES BASIC SCIENCE

1683
01:15:59,475 --> 01:16:05,547
AND WORKS CLOSELY AND IN FACT WE

1684
01:16:05,547 --> 01:16:08,884
HAVE RFAS THAT IS WE DO

1685
01:16:08,884 --> 01:16:09,151
TOGETHER.

1686
01:16:09,151 --> 01:16:10,653
AND THEN WE'RE ACTUALLY THE

1687
01:16:10,653 --> 01:16:15,024
DIVISION THAT WE'RE MOST ALIKE

1688
01:16:15,024 --> 01:16:18,460
WITH IS TCDB.

1689
01:16:18,460 --> 01:16:24,066
WE FOCUS ON PRIMARY AND EARLY

1690
01:16:24,066 --> 01:16:26,068
DETECTION AND ON THE THINGS THAT

1691
01:16:26,068 --> 01:16:29,938
WORK WE HAND THOSE OFF TO DCCP S

1692
01:16:29,938 --> 01:16:31,774
AND THEY FOCUS ON THE

1693
01:16:31,774 --> 01:16:33,175
TRANSLATION OF PRACTICE AND INTO

1694
01:16:33,175 --> 01:16:36,779
THE COMMUNITY AND HOW TO

1695
01:16:36,779 --> 01:16:38,547
ACCELERATE ADOPTION AND

1696
01:16:38,547 --> 01:16:42,284
IMPLEMENTATION.

1697
01:16:42,284 --> 01:16:44,620
SO WE FOCUS IN THREE AREAS AND I

1698
01:16:44,620 --> 01:16:48,123
WILL TALK ABOUT ALL OF THEM.

1699
01:16:48,123 --> 01:16:49,425
PREVENTATIVE AGENTS.

1700
01:16:49,425 --> 01:16:51,894
SCREENING AND EARLY DETECTION

1701
01:16:51,894 --> 01:16:53,562
AND SYMPTOM SCIENCE PREVENTION

1702
01:16:53,562 --> 01:16:54,997
AND MANAGEMENT.

1703
01:16:54,997 --> 01:16:57,566
AND THEY ARE ALL IMPORTANT AS

1704
01:16:57,566 --> 01:16:59,968
I'M SURE YOU APPRECIATE.

1705
01:16:59,968 --> 01:17:01,837
PREVENTIVE AGENTS CAN BE PRIMARY

1706
01:17:01,837 --> 01:17:03,906
AND SECONDARY PREVENTION.

1707
01:17:03,906 --> 01:17:06,442
SECONDARY PREVENTION IS

1708
01:17:06,442 --> 01:17:07,976
SOMETIMES WE CALL INTERCEPTION.

1709
01:17:07,976 --> 01:17:10,446
SCREENING AND EARLY DETECTION.

1710
01:17:10,446 --> 01:17:11,747
WHO'S AT HIGH RISK.

1711
01:17:11,747 --> 01:17:14,583
TWO HAS EARLY CANCER AND WE WANT

1712
01:17:14,583 --> 01:17:17,352
TO PREVENT ADVANCED STAGE CANCER

1713
01:17:17,352 --> 01:17:18,654
AND MORTALITY.

1714
01:17:18,654 --> 01:17:21,890
AND AN IMPORTANT AREA IS SYMPTOM

1715
01:17:21,890 --> 01:17:25,127
SCIENCE AND THE IDEA IS THAT A

1716
01:17:25,127 --> 01:17:26,929
LOT OF SYSTEM MANAGEMENT IS

1717
01:17:26,929 --> 01:17:29,431
TRIAL AND ERROR AND WE WANT TO

1718
01:17:29,431 --> 01:17:30,899
BRING THE SAME LEVEL OF SIGH

1719
01:17:30,899 --> 01:17:34,436
INNINGS TO THE MANAGEMENT OF

1720
01:17:34,436 --> 01:17:36,805
SYMPTOMS AS WE WOULD BRING TO

1721
01:17:36,805 --> 01:17:38,507
TREATMENT OR EVEN PREVENTION SO

1722
01:17:38,507 --> 01:17:43,879
WE WANT TO MOVE TO A PRECISION

1723
01:17:43,879 --> 01:17:45,280
SYMPTOM SCIENCE MODEL.

1724
01:17:45,280 --> 01:17:47,149
SO THERE ARE LOTS OF CAUSES OF

1725
01:17:47,149 --> 01:17:47,983
CANCER.

1726
01:17:47,983 --> 01:17:51,320
AND SOME OF THEM ARE OBVIOUSLY

1727
01:17:51,320 --> 01:17:51,687
AVOIDABLE.

1728
01:17:51,687 --> 01:17:55,524
SOME OF THEM CAN BE PREVENTED IN

1729
01:17:55,524 --> 01:17:57,993
A SECONDARY WAY THROUGH

1730
01:17:57,993 --> 01:17:59,762
INTERVENTIONS.

1731
01:17:59,762 --> 01:18:01,997
OBESITY REMAINS -- TOBACCO

1732
01:18:01,997 --> 01:18:03,065
REMAINS THE MOST IMPORTANT AND

1733
01:18:03,065 --> 01:18:05,033
WE CANNOT DO ENOUGH IN THAT

1734
01:18:05,033 --> 01:18:07,970
SPACE IN TERMS OF POLICY CHANGE

1735
01:18:07,970 --> 01:18:10,639
AND BEHAVIORAL CHANGE TO REDUCE

1736
01:18:10,639 --> 01:18:15,344
TOBACCO DEPENDENCE AND

1737
01:18:15,344 --> 01:18:16,478
PREVENTING YOUNG KIDS FROM

1738
01:18:16,478 --> 01:18:18,847
STARTING TOBACCO.

1739
01:18:18,847 --> 01:18:21,817
OBESITY IS THE COMING EPIDEMIC.

1740
01:18:21,817 --> 01:18:23,352
IT'S BEEN HERE FOR A WHILE AND

1741
01:18:23,352 --> 01:18:25,821
IT WILL CONTINUE AND HOW DO WE

1742
01:18:25,821 --> 01:18:28,657
MITIGATE THE EFFECTS OF OBESITY

1743
01:18:28,657 --> 01:18:29,792
REMAINS TO BE DETERMINED.

1744
01:18:29,792 --> 01:18:32,194
AND THERE ARE OTHER CAUSES.

1745
01:18:32,194 --> 01:18:33,962
FROM A RESEARCH PERSPECTIVE I

1746
01:18:33,962 --> 01:18:37,800
ALSO HAVE AN APPOINTMENT IN

1747
01:18:37,800 --> 01:18:42,504
CANCER EPIGENETICS AND FOCUS ON

1748
01:18:42,504 --> 01:18:46,608
HPV MYSELF FROM AN ESPECIALLY EC

1749
01:18:46,608 --> 01:18:49,411
PERSPECTIVE.

1750
01:18:49,411 --> 01:18:52,414
SO THIS LOOKS COMPLICATED BUT

1751
01:18:52,414 --> 01:18:55,717
IT'S NOT INTENDED TO BE.

1752
01:18:55,717 --> 01:18:58,453
WHEN WE THINK ABOUT CANCER

1753
01:18:58,453 --> 01:18:59,388
PREVENTION WE'RE THINKING ABOUT

1754
01:18:59,388 --> 01:19:01,290
THESE EARLY STAGES BEFORE PEOPLE

1755
01:19:01,290 --> 01:19:02,591
GET CANCER.

1756
01:19:02,591 --> 01:19:06,695
SO TO ME THIS IS THE -- WHILE WE

1757
01:19:06,695 --> 01:19:10,732
STUDY THESE PRECURSERS OR

1758
01:19:10,732 --> 01:19:12,701
PRECANCER OR MUTATIONS EARLY

1759
01:19:12,701 --> 01:19:19,641
MUTATIONS WE'RE TALKING WHEN THE

1760
01:19:19,641 --> 01:19:20,843
BIOLOGY PREVENTION.

1761
01:19:20,843 --> 01:19:24,680
CAN WE MITIGATE THEM.

1762
01:19:24,680 --> 01:19:26,381
NEUTRALIZE THEM BEFORE THEY

1763
01:19:26,381 --> 01:19:27,916
BECOME CANCER.

1764
01:19:27,916 --> 01:19:29,818
IN THIS PROGRESSIVE SCHEME AND

1765
01:19:29,818 --> 01:19:32,621
THIS IS A CARTOON -- THIS IS NOT

1766
01:19:32,621 --> 01:19:34,489
REALLY WHAT ALWAYS HAPPENS OR

1767
01:19:34,489 --> 01:19:37,759
IT'S MORE COMPLICATED IN SOME

1768
01:19:37,759 --> 01:19:39,561
WAYS AND LESS IN SOME WAYS BUT

1769
01:19:39,561 --> 01:19:43,532
AS YOU GET TO THESE MORE SEVERE

1770
01:19:43,532 --> 01:19:45,601
ABNORMALITIES THE RISK IS SHOWN

1771
01:19:45,601 --> 01:19:47,603
AND THE COLOR BECOMES HIGHER AND

1772
01:19:47,603 --> 01:19:51,173
I'M USING THE COLORS DO DENOTE

1773
01:19:51,173 --> 01:20:01,516
THE INCREASED RISK.

1774
01:20:04,052 --> 01:20:09,024
IT'S BASINGLY THE STEP BEFORE

1775
01:20:09,024 --> 01:20:09,691
INVASION.

1776
01:20:09,691 --> 01:20:19,968
* IT BREAKS THROUGH AND IS WHAT

1777
01:20:19,968 --> 01:20:24,539
YOU SEE IN THE EARLY PHASE.

1778
01:20:24,539 --> 01:20:27,743
SO I WANT TO PROMOTE THIS IDEA

1779
01:20:27,743 --> 01:20:29,978
OF SCREENING AWARENESS AND

1780
01:20:29,978 --> 01:20:31,113
VACCINATION FOR EVERYBODY OR

1781
01:20:31,113 --> 01:20:32,514
SAVE CAMPAIGN.

1782
01:20:32,514 --> 01:20:33,982
STOPPING CANCER BEFORE IT

1783
01:20:33,982 --> 01:20:34,449
STARTS.

1784
01:20:34,449 --> 01:20:36,551
AND ON THE LEFT HERE I WANT TO

1785
01:20:36,551 --> 01:20:38,487
HIGHLIGHT THE PARALLELS BETWEEN

1786
01:20:38,487 --> 01:20:39,955
COVID AND CANCER.

1787
01:20:39,955 --> 01:20:42,224
AND I'M SURE DR. LOWY TALKED

1788
01:20:42,224 --> 01:20:45,260
ABOUT WHY THE HPV VACCINE IS

1789
01:20:45,260 --> 01:20:47,162
DIFFERENT THAN THE COVID VACCINE

1790
01:20:47,162 --> 01:20:50,699
AND THAT IS NOT THE POINT.

1791
01:20:50,699 --> 01:20:52,134
WE HAVE THESE TOOLS AND WE NEED

1792
01:20:52,134 --> 01:20:55,304
TO USE THEM AND AT THE SAME TIME

1793
01:20:55,304 --> 01:20:57,606
WE HAD IN THE FIRST TWO YEARS

1794
01:20:57,606 --> 01:21:00,709
THAT WE HAD THE DEATHS DUE TO

1795
01:21:00,709 --> 01:21:02,377
COVID TWICE THE NUMBER OF PEOPLE

1796
01:21:02,377 --> 01:21:04,046
DIED DUE TO CANCER AND THAT IS

1797
01:21:04,046 --> 01:21:05,948
GOING TO KEEP COMING UNLESS WE

1798
01:21:05,948 --> 01:21:08,216
GET BETTER AT PREVENTING IT AND

1799
01:21:08,216 --> 01:21:09,885
HERE ARE SOME OF THE WAYS TO

1800
01:21:09,885 --> 01:21:11,420
PREVENT IT BUT WE NEED MORE

1801
01:21:11,420 --> 01:21:13,288
WAYS.

1802
01:21:13,288 --> 01:21:15,223
PARTICULARLY THOSE LIKE

1803
01:21:15,223 --> 01:21:18,360
PANCREATIC CANCER AND OVARIAN

1804
01:21:18,360 --> 01:21:25,934
CANCER WHICH ARE HIGHLY LETHAL.

1805
01:21:25,934 --> 01:21:27,536
SO LET ME TALK ABOUT RESEARCH

1806
01:21:27,536 --> 01:21:29,604
AND THESE ARE BUSY SLIDES.

1807
01:21:29,604 --> 01:21:31,573
I'M GOING TO DISTILL THEM.

1808
01:21:31,573 --> 01:21:33,275
I WANT YOU TO APPRECIATE THE

1809
01:21:33,275 --> 01:21:35,010
GREAT WORK OF MY DIVISION AND

1810
01:21:35,010 --> 01:21:37,379
THE RESEARCH THAT WE SUPPORT IN

1811
01:21:37,379 --> 01:21:47,823
THE EXTRAMURAL COMMUNITY.

1812
01:21:50,926 --> 01:21:53,628
-- PREVENTATIVE AGENT

1813
01:21:53,628 --> 01:21:55,063
DEVELOPMENT.

1814
01:21:55,063 --> 01:21:57,699
AND WE HAVE -- SOME EXAMPLES OF

1815
01:21:57,699 --> 01:21:58,600
SOME OF THE PROGRAMS THAT WE

1816
01:21:58,600 --> 01:22:01,937
HAVE IN PLACE TO SUPPORT THAT.

1817
01:22:01,937 --> 01:22:06,708
CAP IT -- AND THEN PREVENT IS A

1818
01:22:06,708 --> 01:22:08,944
PRECLINICAL PROGRAM TO HELP

1819
01:22:08,944 --> 01:22:11,847
INVESTIGATORS MOVE THINGS FROM

1820
01:22:11,847 --> 01:22:13,882
THE LAB TO START MOVING THEM

1821
01:22:13,882 --> 01:22:20,622
TOWARDS HUMANS.

1822
01:22:20,622 --> 01:22:25,527
AND N CORP IS OUR NATIONAL AND

1823
01:22:25,527 --> 01:22:30,899
INTERNATIONAL NE NETWORK FOR LAR

1824
01:22:30,899 --> 01:22:32,601
TRIALS.

1825
01:22:32,601 --> 01:22:36,371
AND THERE IS EDRN WHICH IS THE

1826
01:22:36,371 --> 01:22:38,907
EARLY DETECTION RESEARCH NETWORK

1827
01:22:38,907 --> 01:22:41,543
IN ITS 21st YEAR AND I'LL

1828
01:22:41,543 --> 01:22:42,744
SHOW YOU SOME OF THE PROGRESS

1829
01:22:42,744 --> 01:22:45,414
THERE AND WE'VE ESTABLISHED OR

1830
01:22:45,414 --> 01:22:47,315
GOTTEN APPROVALS TO ESTABLISH

1831
01:22:47,315 --> 01:22:49,651
THIS CANCER SCREENING RESEARCH

1832
01:22:49,651 --> 01:22:52,587
NETWORK WHICH WE'RE DOING AT

1833
01:22:52,587 --> 01:22:52,988
DDCPS.

1834
01:22:52,988 --> 01:22:55,657
THAT WAS JUST APPROVED BY THE

1835
01:22:55,657 --> 01:22:58,060
BSA THREE WEEKS AGO.

1836
01:22:58,060 --> 01:22:59,995
AND THEN AGAIN SOME THINGS COULD

1837
01:22:59,995 --> 01:23:02,497
GO INTO N CORP THAT COME OUT OF

1838
01:23:02,497 --> 01:23:04,399
THE CRS

1839
01:23:04,399 --> 01:23:06,768
AND THE SYMPTOM SCIENCE IS THE

1840
01:23:06,768 --> 01:23:08,937
AREA THAT WE HAVE NOT MADE AS

1841
01:23:08,937 --> 01:23:10,972
MUCH PROGRESS BUT WILL BE MAKING

1842
01:23:10,972 --> 01:23:12,841
PROGRESS GOING FORWARD WHICH IS

1843
01:23:12,841 --> 01:23:14,643
IS TO ESTABLISH PROGRAMS TO

1844
01:23:14,643 --> 01:23:17,712
SUPPORT THE DEVELOPMENT OF

1845
01:23:17,712 --> 01:23:19,815
BETTER SYMPTOMS PREVENTION AND

1846
01:23:19,815 --> 01:23:20,282
MANAGEMENT.

1847
01:23:20,282 --> 01:23:22,484
AND THE BEST OF THOSE CAN GO

1848
01:23:22,484 --> 01:23:25,554
INTO N CORP FOR VALIDATION.

1849
01:23:25,554 --> 01:23:28,190
AND WE WANT TO REDUCE CANCER

1850
01:23:28,190 --> 01:23:30,192
INCIDENTS AND MORTALITY AND THE

1851
01:23:30,192 --> 01:23:32,594
R IMPROVE THE QUALITY OF LIFE.

1852
01:23:32,594 --> 01:23:35,263
THESE ARE ALL THINGS THAT WE

1853
01:23:35,263 --> 01:23:39,768
SHARE ON THIS CALL.

1854
01:23:39,768 --> 01:23:43,138
IS SO JUST A LITTLE DEEPER DIVE

1855
01:23:43,138 --> 01:23:44,773
IN THE PIPELINE.

1856
01:23:44,773 --> 01:23:47,709
CAP IT IS A NEW PROGRAM JUST

1857
01:23:47,709 --> 01:23:50,445
COMING OUT NOW FOR TARGETING

1858
01:23:50,445 --> 01:23:52,314
AGENT DISCOVERY.

1859
01:23:52,314 --> 01:23:54,249
REALLY UNDERSTANDING BIOLOGY OF

1860
01:23:54,249 --> 01:23:56,318
EARLY CHANGES AND FIGURING OUT

1861
01:23:56,318 --> 01:24:00,155
HOW WE NEUTRALIZE THOSE

1862
01:24:00,155 --> 01:24:01,356
CARCINOGENIC CHANGES.

1863
01:24:01,356 --> 01:24:04,759
AND PROMISING AGENTS OR

1864
01:24:04,759 --> 01:24:06,461
APPROACHES CAN GO INTO THE

1865
01:24:06,461 --> 01:24:07,829
PREVENT PROGRAM WHICH IS THE

1866
01:24:07,829 --> 01:24:09,131
PRECLINICAL PROGRAM.

1867
01:24:09,131 --> 01:24:13,101
AND IT GOES THROUGH A VARIETY OF

1868
01:24:13,101 --> 01:24:15,937
EVALUATIONS AND WE HAVE A GO, NO

1869
01:24:15,937 --> 01:24:17,739
GO BECAUSE PREVENTION TAKES A

1870
01:24:17,739 --> 01:24:20,342
LONG TIME TO DEMONSTRATE AND

1871
01:24:20,342 --> 01:24:21,877
IT'S EXPENSIVE.

1872
01:24:21,877 --> 01:24:23,145
SO WE HAVE TO BE CRITICAL.

1873
01:24:23,145 --> 01:24:25,514
WE CANNOT JUST THROW CAUTION TO

1874
01:24:25,514 --> 01:24:27,048
THE WIND AND TAKE EVERYTHING

1875
01:24:27,048 --> 01:24:27,482
FORWARD.

1876
01:24:27,482 --> 01:24:31,953
IT HAS TO CUT THE MUSTARD -- AND

1877
01:24:31,953 --> 01:24:32,754
PARTICULARLY BECAUSE WE'RE GOING

1878
01:24:32,754 --> 01:24:36,591
TO BE PUTTING IT IN HEALTHY

1879
01:24:36,591 --> 01:24:36,825
HUMANS.

1880
01:24:36,825 --> 01:24:41,530
SO THE BAR IS VERY HIGH.

1881
01:24:41,530 --> 01:24:43,398
SO HERE IS ONE OF THE BUSY

1882
01:24:43,398 --> 01:24:44,432
SLIDES.

1883
01:24:44,432 --> 01:24:46,568
LOOK AT THE TARGET.

1884
01:24:46,568 --> 01:24:49,137
THESE ARE VACCINE OR VACCINE

1885
01:24:49,137 --> 01:24:51,206
LIKE APPROACHES.

1886
01:24:51,206 --> 01:24:53,642
THIS IS IN THE PREVENT PHASE.

1887
01:24:53,642 --> 01:24:55,911
AND JUST I WANT TO POINT OUT

1888
01:24:55,911 --> 01:24:59,414
JUST FOCUS ON THE TARGETS DON'T

1889
01:24:59,414 --> 01:25:01,616
WORRY ABOUT THE AGENT OR THE

1890
01:25:01,616 --> 01:25:02,584
STATUS.

1891
01:25:02,584 --> 01:25:04,586
THE TARGET POPULATION IS

1892
01:25:04,586 --> 01:25:05,854
PROBABLY OF INTEREST TO THIS

1893
01:25:05,854 --> 01:25:06,821
GROUP.

1894
01:25:06,821 --> 01:25:09,991
THE ONLY THING THAT IS NOT A

1895
01:25:09,991 --> 01:25:12,661
VACCINE IS THE NICOTINE

1896
01:25:12,661 --> 01:25:14,663
ANTIBODY.

1897
01:25:14,663 --> 01:25:17,065
PEOPLE HAVE BEEN FLOATING THE

1898
01:25:17,065 --> 01:25:18,967
IDEA OF A ANYBODY SEEN VACCINE

1899
01:25:18,967 --> 01:25:21,703
BUT THE PROBLEM IS GETTING GOOD

1900
01:25:21,703 --> 01:25:25,040
RESPONSES TO THAT -- IF YOU

1901
01:25:25,040 --> 01:25:28,143
ENARE INJECT NICOTINE AS A

1902
01:25:28,143 --> 01:25:28,577
VACCINE.

1903
01:25:28,577 --> 01:25:31,680
YOU GIVE PEOPLE OF THE ANTIBODY

1904
01:25:31,680 --> 01:25:33,648
THE IMMUNE RESPONSE THAT THEY

1905
01:25:33,648 --> 01:25:33,848
NEED.

1906
01:25:33,848 --> 01:25:35,850
YOU CAN SEE THE DIVERSE NUMBER

1907
01:25:35,850 --> 01:25:41,790
OF ORGANS THAT WE'RE TARGETING

1908
01:25:41,790 --> 01:25:42,958
IN EXPAND.

1909
01:25:42,958 --> 01:25:45,560
MOST OF THESE WON'T WORK.

1910
01:25:45,560 --> 01:25:47,162
THEY WILL FAIL.

1911
01:25:47,162 --> 01:25:48,897
BUT WE HAVE FOR MORE SPECIFIC.

1912
01:25:48,897 --> 01:25:51,866
WE HAVE TO -- IT HAS TO -- WE

1913
01:25:51,866 --> 01:25:54,169
HAVE TO SET A HIGH BAR.

1914
01:25:54,169 --> 01:25:57,239
SO WE MIGHT MISS SOMETHING.

1915
01:25:57,239 --> 01:26:00,675
BUT WE CANNOT HAVE DANGEROUS

1916
01:26:00,675 --> 01:26:02,444
THINGS IN HEALTHY POPULATIONS.

1917
01:26:02,444 --> 01:26:05,814
IT'S NOT GOING TO WORK.

1918
01:26:05,814 --> 01:26:08,316
SO THESE ARE EARLY PHASE

1919
01:26:08,316 --> 01:26:10,151
CLINICAL TRIALS.

1920
01:26:10,151 --> 01:26:12,387
AND WE SEE WE HAVE TWO ON COME

1921
01:26:12,387 --> 01:26:13,288
OH RECTAL.

1922
01:26:13,288 --> 01:26:17,892
ONE THAT IS SUPPOSED TO WORK

1923
01:26:17,892 --> 01:26:21,630
AGAINST COLON AND LUNG.

1924
01:26:21,630 --> 01:26:22,764
THESE HAVE BEEN THROUGH PREVENT

1925
01:26:22,764 --> 01:26:24,232
SO THE PROGRAM IS WORKING.

1926
01:26:24,232 --> 01:26:27,168
YOU CAN SEE THE PYRAMID.

1927
01:26:27,168 --> 01:26:29,271
FEWER THINGS IN E EARLY PHASE.

1928
01:26:29,271 --> 01:26:31,673
MAYBE ONE OR TWO OF THOSE WILL

1929
01:26:31,673 --> 01:26:33,375
GET INTO LATE PHASE AND THAT IS

1930
01:26:33,375 --> 01:26:35,744
HOW IT SHOULD BE.

1931
01:26:35,744 --> 01:26:37,078
AVENUE ALWAYS WILL BE.

1932
01:26:37,078 --> 01:26:39,381
BUT WE'RE VERY' EXCITED ABOUT

1933
01:26:39,381 --> 01:26:41,850
THE FACT THAT WE HAVE A ROBUST

1934
01:26:41,850 --> 01:26:44,219
PROGRAM IN CANCER PREVENTIVE

1935
01:26:44,219 --> 01:26:46,721
VACCINES.

1936
01:26:46,721 --> 01:26:51,092
THIS SHOWS YOU THE GEOGRAPHICAL

1937
01:26:51,092 --> 01:26:51,459
REPRESENTATION.

1938
01:26:51,459 --> 01:26:53,828
THIS IS THE EARLY PHASE CLINICAL

1939
01:26:53,828 --> 01:26:54,195
TRIAL.

1940
01:26:54,195 --> 01:26:56,698
AND EARLY PHASES ARE ABOUT

1941
01:26:56,698 --> 01:26:59,801
SAFETY AND EARLY READ OUTS LIKE

1942
01:26:59,801 --> 01:27:01,436
BIOLOGICAL MARKERS.

1943
01:27:01,436 --> 01:27:03,972
NOT EFFICACY PER SAY.

1944
01:27:03,972 --> 01:27:06,508
ALTHOUGH IN A PHASE II TRIAL YOU

1945
01:27:06,508 --> 01:27:11,546
MIGHT GET A HINT OF EFFICACY

1946
01:27:11,546 --> 01:27:14,382
DEPENDING ON HOW IT'S DESIGNED.

1947
01:27:14,382 --> 01:27:17,519
YOU'VE PROBABLY HEARD OF N CORP

1948
01:27:17,519 --> 01:27:19,287
AND HOW THIS HIGHLIGHTS THE

1949
01:27:19,287 --> 01:27:20,822
NATIONAL AND INTERNATIONAL

1950
01:27:20,822 --> 01:27:31,099
REPRESENTATION.

1951
01:27:32,500 --> 01:27:39,507
I'M SURE YOU'VE HEARD OF THE

1952
01:27:39,507 --> 01:27:41,142
TRIAL.

1953
01:27:41,142 --> 01:27:44,813
YOU SEE THE CUMULATIVE

1954
01:27:44,813 --> 01:27:48,183
ENROLLMENT AS OF NOW WE'RE

1955
01:27:48,183 --> 01:27:49,818
PASSED 50% AND I CANNOT REMEMBER

1956
01:27:49,818 --> 01:27:52,020
WHAT THE NUMBER IS.

1957
01:27:52,020 --> 01:27:56,124
BUT HERE THE Y AXIS IS THE

1958
01:27:56,124 --> 01:27:57,492
NUMBER OF SITES OPENED ACROSS

1959
01:27:57,492 --> 01:27:58,927
THE COUNTRY WHICH IS GOOD

1960
01:27:58,927 --> 01:28:00,528
BECAUSE THAT MEANS THAT WE'RE

1961
01:28:00,528 --> 01:28:02,330
GETTING CLOSER TO A

1962
01:28:02,330 --> 01:28:08,370
REPRESENTATIVE POPULATION.

1963
01:28:08,370 --> 01:28:11,272
WE HAVE 20% AFRICAN-AMERICANS

1964
01:28:11,272 --> 01:28:16,778
ENROLLED IN THIS TRIAL.

1965
01:28:16,778 --> 01:28:20,415
COMING TO THE BIOMARKER WORLD

1966
01:28:20,415 --> 01:28:23,318
HERE IS THE EDRN.

1967
01:28:23,318 --> 01:28:27,756
OUR BIOMARKER DISCOVERY OR PART

1968
01:28:27,756 --> 01:28:29,424
OF WE HAVE LABORATORIES AND

1969
01:28:29,424 --> 01:28:31,192
CENTERS ACROSS THE COUNTRY.

1970
01:28:31,192 --> 01:28:34,162
WORKING ON A VARIETY OF TUMORS

1971
01:28:34,162 --> 01:28:36,030
TO GET MARKERS THAT ARE

1972
01:28:36,030 --> 01:28:42,303
ASSOCIATED WITH EARLY CANCER.

1973
01:28:42,303 --> 01:28:44,339
AGAIN DO NOT GET CAUGHT UP IN

1974
01:28:44,339 --> 01:28:46,174
THE COMPLEX SLIDE HERE.

1975
01:28:46,174 --> 01:28:49,377
I JUST WANT TO CALL OUT THE EDRN

1976
01:28:49,377 --> 01:28:51,980
AND ALL THAT THEY'VE DONE AND

1977
01:28:51,980 --> 01:28:54,149
HERE ARE EXAMPLES OF FDA

1978
01:28:54,149 --> 01:28:56,284
APPROVED TESTS AND YOU CAN READ

1979
01:28:56,284 --> 01:28:58,119
THESE LATER AND LOOK THEM UP AND

1980
01:28:58,119 --> 01:29:00,388
SEE WHAT IS HAPPENING.

1981
01:29:00,388 --> 01:29:07,862
NEXT SLIDE IS A LIST OF CLIA

1982
01:29:07,862 --> 01:29:08,229
TESTS.

1983
01:29:08,229 --> 01:29:10,198
NOT TO GET INTO THE SPECIFICS.

1984
01:29:10,198 --> 01:29:12,534
JUST TO HIGHLIGHT THAT WE'RE

1985
01:29:12,534 --> 01:29:14,803
DOING A LOT AND NOT ALL OF THESE

1986
01:29:14,803 --> 01:29:17,505
ARE GOING TO WORK.

1987
01:29:17,505 --> 01:29:20,475
NOT ALL WILL BE USED BUT THE

1988
01:29:20,475 --> 01:29:22,677
BIGGER THE BASE THE MORE THAT

1989
01:29:22,677 --> 01:29:25,213
WILL MAKE INTO IT IN THE PUBLIC

1990
01:29:25,213 --> 01:29:28,716
FOR THE PUBLIC GOOD.

1991
01:29:28,716 --> 01:29:31,319
AND THAT IS A WORTHWHILE GOAL.

1992
01:29:31,319 --> 01:29:33,788
SO WE TALK ABOUT PREVENTIVE

1993
01:29:33,788 --> 01:29:36,558
AGENTS AND BIOMARKERS.

1994
01:29:36,558 --> 01:29:38,927
AND WHAT I CALL MY HOLY GRAIL

1995
01:29:38,927 --> 01:29:40,795
THE PRECISION CANCER PREVENTION

1996
01:29:40,795 --> 01:29:44,599
AND I'LL EXPAND THAT A LITTLE

1997
01:29:44,599 --> 01:29:46,701
LATER IF WE KNOW THE BIOMARKER

1998
01:29:46,701 --> 01:29:49,103
THAT TELLS THE PERSONS AT RISK

1999
01:29:49,103 --> 01:29:50,839
WE MAY KNOW SOMETHING ABOUT HOW

2000
01:29:50,839 --> 01:29:53,208
TO MITIGATE THAT RISK AND WE MAY

2001
01:29:53,208 --> 01:29:56,678
BE ABLE TO COMBINE THOSE TWO TO

2002
01:29:56,678 --> 01:29:58,746
MITIGATE CANCER RISK AND THAT

2003
01:29:58,746 --> 01:30:00,648
MOVES US AWAY FROM CUTTING

2004
01:30:00,648 --> 01:30:01,082
PEOPLE.

2005
01:30:01,082 --> 01:30:03,251
OR BLADING OR USING PHYSICAL

2006
01:30:03,251 --> 01:30:05,453
METHODS TO REDUCE RISK.

2007
01:30:05,453 --> 01:30:08,823
AND I'M SURE YOU ALL KNOW THAT

2008
01:30:08,823 --> 01:30:13,461
MANY WOMEN FOR EXAMPLE BRCA

2009
01:30:13,461 --> 01:30:18,933
CARRIERS HAVE -- THE MASTECTOMY

2010
01:30:18,933 --> 01:30:22,804
AND THAT IS THE ONLY RISK

2011
01:30:22,804 --> 01:30:24,005
REDUCTION.

2012
01:30:24,005 --> 01:30:26,107
AND 100 YEARS FROM NOW PEOPLE

2013
01:30:26,107 --> 01:30:28,610
WILL LOOK BACK AND SAY THAT THAT

2014
01:30:28,610 --> 01:30:30,912
WAS BARBARIC AND I HOPE WE GET

2015
01:30:30,912 --> 01:30:32,447
TO THAT POINT WHERE WE LOOK IN

2016
01:30:32,447 --> 01:30:34,716
THE PAST AND SAY THAT IS -- YOU

2017
01:30:34,716 --> 01:30:37,151
GUYS DID WHAT?

2018
01:30:37,151 --> 01:30:40,555
NEXT SLIDE, PLEASE.

2019
01:30:40,555 --> 01:30:43,892
SO AS I SAID SYMPTOM MANAGEMENT

2020
01:30:43,892 --> 01:30:46,895
AND TOXICITY SITS IN OUR

2021
01:30:46,895 --> 01:30:48,029
DIVISION.

2022
01:30:48,029 --> 01:30:50,498
I'M VERY EXCITED ABOUT THIS

2023
01:30:50,498 --> 01:30:52,500
BECAUSE I'VE WATCHED FAMILY

2024
01:30:52,500 --> 01:30:55,303
MEMBERS GO THROUGH CANCER.

2025
01:30:55,303 --> 01:31:00,775
MY WIFE IN 2013 WAS DIAGNOSED

2026
01:31:00,775 --> 01:31:03,778
WITH STAGE 4 ENDOMETRIAL CANCER

2027
01:31:03,778 --> 01:31:05,647
AND BEFORE SHE PASSED AWAY IT

2028
01:31:05,647 --> 01:31:08,483
WAS A MANAGEMENT OF SYMPTOMS.

2029
01:31:08,483 --> 01:31:10,618
A FULL-TIME JOB AND IT WAS

2030
01:31:10,618 --> 01:31:11,486
HIT-AND-MISS.

2031
01:31:11,486 --> 01:31:14,022
AND I THINK WE CAN APPLY THE

2032
01:31:14,022 --> 01:31:16,157
SAME SCIENTIFIC RIGOR FOR

2033
01:31:16,157 --> 01:31:17,825
ONCOLOGY AND PREVENTION TO THIS

2034
01:31:17,825 --> 01:31:18,326
FIELD.

2035
01:31:18,326 --> 01:31:22,664
SO AT THE BASE OF THIS LIKE THAT

2036
01:31:22,664 --> 01:31:24,232
T0 IS UNDERSTANDING WHY PEOPLE

2037
01:31:24,232 --> 01:31:25,199
GET SYMPTOMS.

2038
01:31:25,199 --> 01:31:27,201
BECAUSE NOT EVERYBODY GETS THE

2039
01:31:27,201 --> 01:31:29,470
SAME SYMPTOMS.

2040
01:31:29,470 --> 01:31:32,407
NOT EVERYBODY GETS A SYMPTOM FOR

2041
01:31:32,407 --> 01:31:34,409
A GIVEN TREATMENT AND PEOPLE

2042
01:31:34,409 --> 01:31:36,177
HAVE SYMPTOMS RELATED TO HAVING

2043
01:31:36,177 --> 01:31:37,011
CANCER ITSELF.

2044
01:31:37,011 --> 01:31:39,948
SO WE REALLY NEED TO DO A BETTER

2045
01:31:39,948 --> 01:31:41,583
JOB OF UNDERSTANDING WHO GETS

2046
01:31:41,583 --> 01:31:42,317
ONE.

2047
01:31:42,317 --> 01:31:44,686
WHY DO SOME PEOPLE GET MORE

2048
01:31:44,686 --> 01:31:46,988
ADDICTED TO OPIOIDS THAN OTHERS.

2049
01:31:46,988 --> 01:31:49,924
THAT IS ALSO IMPORTANT.

2050
01:31:49,924 --> 01:31:54,395
SO THEN WE NEED TO CHARACTERIZE

2051
01:31:54,395 --> 01:31:56,531
CLINICAL SYNDROME FOR TOXICITY

2052
01:31:56,531 --> 01:32:02,537
AND SYNDROMES -- WE GET BETTER

2053
01:32:02,537 --> 01:32:03,738
AT COLLECTING DATA.

2054
01:32:03,738 --> 01:32:06,841
AND PUTTING THOSE TO THE IN A

2055
01:32:06,841 --> 01:32:08,176
COMBINED MEASURE.

2056
01:32:08,176 --> 01:32:11,379
AND IT'S REALLY IMPORTANT THAT

2057
01:32:11,379 --> 01:32:16,250
WE TALK TO OUR PATIENTS AND

2058
01:32:16,250 --> 01:32:17,552
UNDERSTAND WHAT THEY ARE GOING

2059
01:32:17,552 --> 01:32:19,988
THROUGH AND COLLECT THAT

2060
01:32:19,988 --> 01:32:20,455
INFORMATION.

2061
01:32:20,455 --> 01:32:22,624
THERE IS NO OTHER WAY TO MAKE

2062
01:32:22,624 --> 01:32:23,157
PROGRESS ON THIS.

2063
01:32:23,157 --> 01:32:29,530
I CANNOT BE MORE STRON STRONG

2064
01:32:29,530 --> 01:32:31,566
SUPPORTIVE OF THIS AREA.

2065
01:32:31,566 --> 01:32:34,535
CANCER PATIENTS AND CANCER

2066
01:32:34,535 --> 01:32:36,204
SURVIVORS HAVE SIGNIFICANT

2067
01:32:36,204 --> 01:32:39,040
SYMPTOMS THAT PREVENT THEM FROM

2068
01:32:39,040 --> 01:32:41,042
GETTING THE NEXT THERAPY.

2069
01:32:41,042 --> 01:32:42,777
RIGHT

2070
01:32:42,777 --> 01:32:45,046
SO THERE IS A THING CALLED

2071
01:32:45,046 --> 01:32:47,849
CLINICAL PERFORMANCE AND THE

2072
01:32:47,849 --> 01:32:49,884
ONCOLOGIST LOOKS AT THE PATIENT

2073
01:32:49,884 --> 01:32:51,719
AND SAID YES YOU CAN GO TO THE

2074
01:32:51,719 --> 01:32:52,754
NEXT THERAPY.

2075
01:32:52,754 --> 01:32:54,088
NO YOU CANNOT.

2076
01:32:54,088 --> 01:32:55,490
BASED ON THEIR HEALTH AND

2077
01:32:55,490 --> 01:32:55,990
WELL-BEING.

2078
01:32:55,990 --> 01:32:57,892
SO THE BETTER WE TAKE CARE OF

2079
01:32:57,892 --> 01:32:59,794
OUR PATIENTS THE MORE LIKELY

2080
01:32:59,794 --> 01:33:01,229
THEY ARE GOING TO GET TO THE

2081
01:33:01,229 --> 01:33:03,431
NEXT LINE OF THERAPY AND EVEN

2082
01:33:03,431 --> 01:33:05,066
SURVIVE LONG ENOUGH TO GET TO

2083
01:33:05,066 --> 01:33:07,235
THERAPIES THAT HAVE NOT BEEN

2084
01:33:07,235 --> 01:33:09,103
INVENTED TODAY BUT WILL BE

2085
01:33:09,103 --> 01:33:09,971
TOMORROW.

2086
01:33:09,971 --> 01:33:13,041
SO THERE IS A REALLY IMPORTANT

2087
01:33:13,041 --> 01:33:13,641
INTERACTION BETWEEN BETTER

2088
01:33:13,641 --> 01:33:16,678
SYMPTOM MANAGEMENT, SURVIVORSHIP

2089
01:33:16,678 --> 01:33:19,580
AND ALSO THERAPY EFFICACY.

2090
01:33:19,580 --> 01:33:22,417
AND I'M NOT TALKING ABOUT A

2091
01:33:22,417 --> 01:33:22,950
SINGLE THERAPY.

2092
01:33:22,950 --> 01:33:24,452
I'M TALKING ABOUT THE FULL

2093
01:33:24,452 --> 01:33:29,624
COURSE OF MANAGING CANCER.

2094
01:33:29,624 --> 01:33:32,060
WE'RE ALSO LOOKING "AT ISSUES"

2095
01:33:32,060 --> 01:33:34,696
AROUND CANNABIS.

2096
01:33:34,696 --> 01:33:37,165
BOTH AS THE USE AND ABUSE.

2097
01:33:37,165 --> 01:33:39,500
AND THERE IS GOING TO BE A NEW

2098
01:33:39,500 --> 01:33:41,302
FUNDING OPPORTUNITY AROUND THIS.

2099
01:33:41,302 --> 01:33:43,738
THIS WAS A WORKSHOP THAT LED TO

2100
01:33:43,738 --> 01:33:51,546
THIS FUNDING OPPORTUNITIES.

2101
01:33:51,546 --> 01:33:54,182
* I KNOW THAT WE TALKED ABOUT A

2102
01:33:54,182 --> 01:34:02,490
BIOLOGICAL MODEL FOR PRECISION

2103
01:34:02,490 --> 01:34:04,659
CANCER MANAGEMENT BUT I WANT TO

2104
01:34:04,659 --> 01:34:06,427
BROADEN IT.

2105
01:34:06,427 --> 01:34:07,729
INCLUDING SOCIAL DETERMINANTS.

2106
01:34:07,729 --> 01:34:11,733
AND THE DEVELOPMENT AND

2107
01:34:11,733 --> 01:34:13,034
TARGETING.

2108
01:34:13,034 --> 01:34:14,402
CONSIDER AND I THINK YOU WERE

2109
01:34:14,402 --> 01:34:20,675
TALKING ABOUT THIS -- THE BASIC

2110
01:34:20,675 --> 01:34:22,777
SCIENCE THAT HAS FUELED OUR

2111
01:34:22,777 --> 01:34:24,178
PREVENTION.

2112
01:34:24,178 --> 01:34:26,180
SEVERAL EXAMPLES RELATED TO

2113
01:34:26,180 --> 01:34:30,585
PEOPLE OF AFRICAN DESCENT.

2114
01:34:30,585 --> 01:34:34,188
ON CO-TYPE DX.

2115
01:34:34,188 --> 01:34:36,491
HPV35 IS NOT INCLUDED IN THE

2116
01:34:36,491 --> 01:34:46,534
CURRENT VACCINES.

2117
01:34:46,534 --> 01:34:48,436
AND ITSELF KNOW FROM PERSONAL

2118
01:34:48,436 --> 01:34:50,071
EXPERIENCES WHEN WE'VE DONE SOME

2119
01:34:50,071 --> 01:34:55,977
WORK IN NIGERIA TO COMPARE

2120
01:34:55,977 --> 01:34:59,514
RESEARCH THAT THERE WAS NOT A

2121
01:34:59,514 --> 01:35:01,949
REPRESENTATIVE GROUP OF

2122
01:35:01,949 --> 01:35:03,117
AFRICAN-AMERICANS IN THE

2123
01:35:03,117 --> 01:35:05,686
DATABASE.

2124
01:35:05,686 --> 01:35:08,589
AND AN INCLUSION MODEL WILL

2125
01:35:08,589 --> 01:35:11,025
IMPROVE REPRESENTATIVENESS IN

2126
01:35:11,025 --> 01:35:13,694
RESEARCH REDUCING THE A FOR

2127
01:35:13,694 --> 01:35:15,163
MENTIONED BIASES.

2128
01:35:15,163 --> 01:35:17,765
IT'S NOT JUST WHAT YOU DELIVER

2129
01:35:17,765 --> 01:35:19,767
BUT TO WHOM AND HOW AND WHERE.

2130
01:35:19,767 --> 01:35:24,705
AND WE'LL TALK MORE ABOUT THAT

2131
01:35:24,705 --> 01:35:26,374
IN THE NEXT SLIDE.

2132
01:35:26,374 --> 01:35:30,211
I THINK WE CAN ALL AGREE THAT IT

2133
01:35:30,211 --> 01:35:32,513
ONLY WORKS FOR A FRACTION OF THE

2134
01:35:32,513 --> 01:35:35,216
POPULATION AND WE WILL NEED NEW

2135
01:35:35,216 --> 01:35:37,251
STRATEGIES TO REACH EVERYBODY.

2136
01:35:37,251 --> 01:35:39,020
THIS IS LAYING IT OUT.

2137
01:35:39,020 --> 01:35:40,721
THE WHO.

2138
01:35:40,721 --> 01:35:42,723
LOOK AT POPULATION RISK.

2139
01:35:42,723 --> 01:35:44,292
CONSIDER BENEFITS TO HARMS.

2140
01:35:44,292 --> 01:35:46,194
THE WHAT IS THE BIOLOGICAL

2141
01:35:46,194 --> 01:35:47,728
TARGETING.

2142
01:35:47,728 --> 01:35:49,030
THE MODE OF DELIVERY.

2143
01:35:49,030 --> 01:35:51,365
WE DON'T HAVE TO DO THINGS JUST

2144
01:35:51,365 --> 01:35:53,167
THROUGH INJECTION OR ORALLY.

2145
01:35:53,167 --> 01:35:54,902
WE CAN THINK ABOUT DIFFERENT

2146
01:35:54,902 --> 01:35:57,572
WAYS OF DELIVERING THE SAME

2147
01:35:57,572 --> 01:36:01,075
INTERVENTION THAT MAY BE MORE

2148
01:36:01,075 --> 01:36:03,611
APPLICABLE AND AMENABLE TO HIGH

2149
01:36:03,611 --> 01:36:08,049
RISK POPULATIONS OR UNDERSERVED

2150
01:36:08,049 --> 01:36:09,250
POPULATIONS AND REDUCE THE HARMS

2151
01:36:09,250 --> 01:36:15,223
FOR THE THE SAME INTERVENTION.

2152
01:36:15,223 --> 01:36:18,025
AND THEN ACCESSIBILITY.

2153
01:36:18,025 --> 01:36:19,961
THERE ARE OTHER THINGS THAT WE

2154
01:36:19,961 --> 01:36:21,863
CAN DO.

2155
01:36:21,863 --> 01:36:24,232
FIT TESTING AND I'LL TALK ABOUT

2156
01:36:24,232 --> 01:36:25,032
THIS LATER.

2157
01:36:25,032 --> 01:36:27,535
THE IDEA OF BUNDLING.

2158
01:36:27,535 --> 01:36:30,171
IF YOU OFFER SELF-COLLECTION HPV

2159
01:36:30,171 --> 01:36:32,039
TESTING TO A WOMAN AT HOME WHAT

2160
01:36:32,039 --> 01:36:34,475
CAN YOU OFFER TO HER AND HER

2161
01:36:34,475 --> 01:36:38,145
FAMILY OR HER HOUSE MATES.

2162
01:36:38,145 --> 01:36:41,449
IF THERE IS A MAN THERE THEY

2163
01:36:41,449 --> 01:36:43,618
PROBABLY NEED FIT TESTING AND

2164
01:36:43,618 --> 01:36:54,028
THESE TEND TO CORRELATE.

2165
01:36:54,262 --> 01:36:57,932
THIS IS THE MODEL THAT I WANT TO

2166
01:36:57,932 --> 01:36:59,400
PUT FORWARD.

2167
01:36:59,400 --> 01:37:01,002
WE DO WANT TO HIT THAT

2168
01:37:01,002 --> 01:37:04,038
BULL'S-EYE.

2169
01:37:04,038 --> 01:37:06,140
A LOT OF DATA HERE AND I'M GOING

2170
01:37:06,140 --> 01:37:08,876
TO TAKE YOU TO THE RED.

2171
01:37:08,876 --> 01:37:12,013
SO WHEN WE DO SELF-COLLECTION

2172
01:37:12,013 --> 01:37:15,116
AND WE USE A PCR TEST WHAT WE

2173
01:37:15,116 --> 01:37:20,021
SEE IS THE SELF-COLLECTED SAMPLE

2174
01:37:20,021 --> 01:37:23,024
-- ON HER OWN WITHOUT A PELVIC

2175
01:37:23,024 --> 01:37:24,992
EXAMPLE WORKS JUST AS WELL AS

2176
01:37:24,992 --> 01:37:28,029
THE PROVIDER COLLECTED SAMPLE

2177
01:37:28,029 --> 01:37:30,431
AND I'VE DONE STUDIES ALL OVER

2178
01:37:30,431 --> 01:37:33,334
THE WORLD AND I'VE TALKED TO

2179
01:37:33,334 --> 01:37:36,837
PEOPLE -- THE ONE THING THAT

2180
01:37:36,837 --> 01:37:38,372
WOMEN WORRY ABOUT IS THAT THEY

2181
01:37:38,372 --> 01:37:40,174
WILL DO IT AS WELL AS THE

2182
01:37:40,174 --> 01:37:40,942
PROVIDER.

2183
01:37:40,942 --> 01:37:44,512
OTHERWISE THEY LOVE IT.

2184
01:37:44,512 --> 01:37:47,381
I'VE DONE THIS IN LIVE AUDIENCES

2185
01:37:47,381 --> 01:37:50,051
BUT I'VE GIVEN TALKS -- HUNDREDS

2186
01:37:50,051 --> 01:37:53,020
OF TALKS AND TALKED TO THOUSANDS

2187
01:37:53,020 --> 01:37:55,589
OF PEOPLE AND I ASK ALL THE TIME

2188
01:37:55,589 --> 01:37:58,392
HOW MANY WOMEN LIKE HAVING A

2189
01:37:58,392 --> 01:38:01,395
PELVIC EXTRA AND NOBODY HAS YET

2190
01:38:01,395 --> 01:38:03,197
RAISED THEIR HAND.

2191
01:38:03,197 --> 01:38:03,965
SURPRISE, SURPRISE.

2192
01:38:03,965 --> 01:38:07,802
HOW MANY MEN LIKE A PROSTATE

2193
01:38:07,802 --> 01:38:08,636
EXAM.

2194
01:38:08,636 --> 01:38:10,671
NO ONE RAISES THEIR HAND FOR

2195
01:38:10,671 --> 01:38:11,806
THAT EITHER.

2196
01:38:11,806 --> 01:38:15,276
WE LOOKED AT DIFFERENT

2197
01:38:15,276 --> 01:38:16,711
STRATEGIES TO REACH UNDERSERVED

2198
01:38:16,711 --> 01:38:18,879
WOMEN.

2199
01:38:18,879 --> 01:38:21,082
IF WE MAIL KITS TO THEM WE CAN

2200
01:38:21,082 --> 01:38:23,117
GET AN INCREASE IN PARTICIPATION

2201
01:38:23,117 --> 01:38:25,319
IN SCREENING BY 13%.

2202
01:38:25,319 --> 01:38:28,522
BUT IF WE DO MORE ACTIVE

2203
01:38:28,522 --> 01:38:30,091
ENGAGEMENT A DOOR-TO-DOOR

2204
01:38:30,091 --> 01:38:34,428
STRATEGY WE CAN GET TOWN A 40%

2205
01:38:34,428 --> 01:38:38,766
INCREASE IN SCREENING.

2206
01:38:38,766 --> 01:38:41,135
I'VE DONE A LOT OF WORK IN

2207
01:38:41,135 --> 01:38:43,637
MISSISSIPPI AND OTHER PLACES ON

2208
01:38:43,637 --> 01:38:45,740
SELF-COLLECTION.

2209
01:38:45,740 --> 01:38:48,009
I'M GOING TO SUMMARIZE.

2210
01:38:48,009 --> 01:38:53,581
THE FIRST TIME WE DID THIS STUDY

2211
01:38:53,581 --> 01:38:58,185
IN 2009 AND 2010 -- AND THE

2212
01:38:58,185 --> 01:39:00,221
BOTTOM LINE WAS WOMEN WERE FOUR

2213
01:39:00,221 --> 01:39:02,456
TIMES MORE LIKELY TO CHOOSE AND

2214
01:39:02,456 --> 01:39:05,526
COMPLETE SELF-COLLECTION.

2215
01:39:05,526 --> 01:39:14,001
WHEN WE DID A SECOND STUDY --

2216
01:39:14,001 --> 01:39:15,836
WOMEN WERE FIVE TIMES MORE

2217
01:39:15,836 --> 01:39:18,506
LIKELY TO SELECT CHOICE THAN

2218
01:39:18,506 --> 01:39:21,475
CLINIC BASED SCREENING AND AMONG

2219
01:39:21,475 --> 01:39:23,377
THOSE WOMEN WERE 20 TIMES MORE

2220
01:39:23,377 --> 01:39:29,050
LIKELY TO DO AND COMPLETE

2221
01:39:29,050 --> 01:39:29,517
SELF-DETECTION.

2222
01:39:29,517 --> 01:39:31,852
THIS IS THEIR CHOICE SO IT'S NOT

2223
01:39:31,852 --> 01:39:35,389
JUST HYPOTHETICAL.

2224
01:39:35,389 --> 01:39:37,691
THEY ARE ACTUALLY VOTING WITH

2225
01:39:37,691 --> 01:39:39,326
THEIR FEET IF YOU WILL.

2226
01:39:39,326 --> 01:39:40,961
NEXT SLIDE.

2227
01:39:40,961 --> 01:39:44,231
SO WE'RE WORKING CLOSELY WITH

2228
01:39:44,231 --> 01:39:49,503
THE FDA TO TRY TO GET

2229
01:39:49,503 --> 01:39:52,239
SELF-COLLECTION TESTING APPROVED

2230
01:39:52,239 --> 01:39:54,442
SO IT CAN BE REIMBURSED AND

2231
01:39:54,442 --> 01:39:56,444
PROVIDED TO ALL WOMEN AND

2232
01:39:56,444 --> 01:39:57,645
IMPORTANTLY TO THOSE WOMEN WHO

2233
01:39:57,645 --> 01:40:00,448
DON'T COME TO CLINIC BECAUSE

2234
01:40:00,448 --> 01:40:02,716
THEY DON'T HAVE RESOURCES OR

2235
01:40:02,716 --> 01:40:06,253
THERE ARE GEOGRAPHICAL BARRIERS.

2236
01:40:06,253 --> 01:40:09,590
AND I LEFT OUT A SLIDE BUT WE

2237
01:40:09,590 --> 01:40:11,659
CAN THINK ABOUT THIS FOR OTHER

2238
01:40:11,659 --> 01:40:12,726
DISEASES.

2239
01:40:12,726 --> 01:40:15,229
AS I SAID FIT COULD BE ADDED TO

2240
01:40:15,229 --> 01:40:16,931
SOMETHING LIKE THIS AS PART OF A

2241
01:40:16,931 --> 01:40:18,332
COMMUNITY OUTREACH.

2242
01:40:18,332 --> 01:40:19,733
AND THE FIT COULD BE FOR THE

2243
01:40:19,733 --> 01:40:20,367
WOMEN.

2244
01:40:20,367 --> 01:40:21,402
FOR THE HUSBAND.

2245
01:40:21,402 --> 01:40:23,704
WE CAN THINK ABOUT SMOKING

2246
01:40:23,704 --> 01:40:25,806
PREVENTION AND CESSATION IN THE

2247
01:40:25,806 --> 01:40:26,774
SAME VISIT.

2248
01:40:26,774 --> 01:40:28,476
AND BY THE WAY THERE IS SOME

2249
01:40:28,476 --> 01:40:30,644
EVIDENCE THAT YOU CAN MEASURE

2250
01:40:30,644 --> 01:40:37,518
HIGH PIE LORI.

2251
01:40:37,518 --> 01:40:48,062
WE CAN THINK ABOUT * NOVEL --

2252
01:40:48,596 --> 01:40:51,632
DONE BY PREPARATION FOR PSA FOR

2253
01:40:51,632 --> 01:40:55,736
MEN WHO ARE AT HIGH RISK FOR

2254
01:40:55,736 --> 01:40:56,403
PROSTATE CANCER.

2255
01:40:56,403 --> 01:40:57,638
YOU GET THE IDEA.

2256
01:40:57,638 --> 01:41:00,040
ONCE YOU'VE OPENED THE DOOR TO

2257
01:41:00,040 --> 01:41:01,842
AN UNDERSERVED PERSON OR FAMILY

2258
01:41:01,842 --> 01:41:03,077
THEY HAVE A LOT OF NEEDS AND

2259
01:41:03,077 --> 01:41:05,146
THINK OF THIS AS A MODERN

2260
01:41:05,146 --> 01:41:07,314
VERSION OF THE HOME VISIT.

2261
01:41:07,314 --> 01:41:09,150
YOU'RE PROBABLY TOO YOUNG TO

2262
01:41:09,150 --> 01:41:10,651
REMEMBER THIS BUT I REMEMBER

2263
01:41:10,651 --> 01:41:12,853
HOME VISITS FROM MY

2264
01:41:12,853 --> 01:41:14,288
PEDIATRICIAN.

2265
01:41:14,288 --> 01:41:15,956
SO THIS WOULD BE A DIFFERENT

2266
01:41:15,956 --> 01:41:18,859
KIND OF DELIVERY BUT THE IDEA

2267
01:41:18,859 --> 01:41:22,296
THAT IS WE CAN DECENTRALIZE AND

2268
01:41:22,296 --> 01:41:23,898
DEMOCRATIZE INTERVENTIONS

2269
01:41:23,898 --> 01:41:25,199
RELATED TO PREVENTION AND GET

2270
01:41:25,199 --> 01:41:27,601
MORE PEOPLE TO DO PREVENTIVE

2271
01:41:27,601 --> 01:41:29,170
SERVICES AND THIS SHOULD NOT

2272
01:41:29,170 --> 01:41:30,304
STOP AT CANCER.

2273
01:41:30,304 --> 01:41:33,174
IT SHOULD GO TO CHRONIC DISEASES

2274
01:41:33,174 --> 01:41:35,376
LIKE DIABETES AND CARDIOVASCULAR

2275
01:41:35,376 --> 01:41:37,178
DISEASE.

2276
01:41:37,178 --> 01:41:38,612
AGAIN A BUSY SLIDE.

2277
01:41:38,612 --> 01:41:40,581
BUT I WANT TO COME BACK TO A

2278
01:41:40,581 --> 01:41:44,385
POINT.

2279
01:41:44,385 --> 01:41:51,458
WE RECOMMEND OUR PEOPLE US USE O

2280
01:41:51,458 --> 01:41:57,097
MAX FINISH.

2281
01:41:57,097 --> 01:42:00,868
-- TAMOXIFEN.

2282
01:42:00,868 --> 01:42:03,370
WE * WOULD REDUCE THOSE

2283
01:42:03,370 --> 01:42:05,472
TOXICITIES AND ACHIEVE THE SAME

2284
01:42:05,472 --> 01:42:06,173
RESULTS.

2285
01:42:06,173 --> 01:42:08,042
SO WE HAVE FOUR STUDIES LOOKING

2286
01:42:08,042 --> 01:42:10,211
AT BIOMARKERS RELATED TO WHETHER

2287
01:42:10,211 --> 01:42:16,517
THIS IS GOING TO WORK.

2288
01:42:16,517 --> 01:42:19,153
SO I WANT TO TALK ABOUT

2289
01:42:19,153 --> 01:42:20,688
MULTI-CANCER EARLY DETECTION AND

2290
01:42:20,688 --> 01:42:23,157
ONLY TO SAY THAT THERE IS A LOT

2291
01:42:23,157 --> 01:42:25,726
OF CHATTER AND THERE IS A LOT OF

2292
01:42:25,726 --> 01:42:26,360
UNKNOWN.

2293
01:42:26,360 --> 01:42:28,295
AND I'M SURE YOU HAVE HEARD

2294
01:42:28,295 --> 01:42:30,831
ABOUT THIS AND ARE EXCITED ABOUT

2295
01:42:30,831 --> 01:42:34,768
IT AND AS A PUBLIC HEALTH

2296
01:42:34,768 --> 01:42:36,370
NONPHYSICIAN PhD I NEED TO

2297
01:42:36,370 --> 01:42:39,640
SPEAK UP ABOUT THIS AND RIGHT

2298
01:42:39,640 --> 01:42:44,545
SIZE IT.

2299
01:42:44,545 --> 01:42:46,513
SO THIS IS WHAT IT FEELS LIKE

2300
01:42:46,513 --> 01:42:50,618
AND WE CALL THIS THE TSUNAMI.

2301
01:42:50,618 --> 01:42:53,621
AND THERE ARE LOTS OF COMPANIES

2302
01:42:53,621 --> 01:42:57,224
ENTERING THE SPACE.

2303
01:42:57,224 --> 01:43:02,062
AND THE CARTOON -- IT SAYS I

2304
01:43:02,062 --> 01:43:06,700
THINK I WOULD LIKE TO HAVE AN

2305
01:43:06,700 --> 01:43:10,437
MCED TEST DOC BUT WHICH ONE?

2306
01:43:10,437 --> 01:43:12,206
EACH TARGET DIFFERENT CANCERS

2307
01:43:12,206 --> 01:43:17,144
AND THERE IS A LOT OF DIRECT TO

2308
01:43:17,144 --> 01:43:20,881
CONSUMER -- AND HOW DO THEY SORT

2309
01:43:20,881 --> 01:43:22,983
THROUGH ALL OF THE NOISE?

2310
01:43:22,983 --> 01:43:26,520
IF YOU DON'T KNOW WHAT THIS IS

2311
01:43:26,520 --> 01:43:29,323
IS MULTI-CANCER EARLY DETECTION

2312
01:43:29,323 --> 01:43:31,825
-- LOOKING FOR SIGNALS FOR ONE

2313
01:43:31,825 --> 01:43:35,162
OR MORE CANCERS IN THE EARLY

2314
01:43:35,162 --> 01:43:38,032
CANCER IN THE BLOODED  WITH IDEA

2315
01:43:38,032 --> 01:43:40,167
THAT IF WE CAN INTERVENE SOON

2316
01:43:40,167 --> 01:43:44,571
ENOUGH WE CAN PREVENT MORTALITY.

2317
01:43:44,571 --> 01:43:50,244
THE MULTI-CANCER EARLY DESECTION

2318
01:43:50,244 --> 01:43:51,512
ASSAYS MEASURE DIFFERENT THINGS

2319
01:43:51,512 --> 01:43:53,480
IN THE BLOOD FOR DIFFERENT

2320
01:43:53,480 --> 01:43:53,947
CANCER.

2321
01:43:53,947 --> 01:43:57,184
A POSITIVE IS A SIGNAL FOR

2322
01:43:57,184 --> 01:43:59,987
CANCER BUT DOES NOT DIAGNOSE

2323
01:43:59,987 --> 01:44:00,654
CANCER.

2324
01:44:00,654 --> 01:44:03,390
SOME POINT TO A TISSUE OF ORIGIN

2325
01:44:03,390 --> 01:44:07,494
BUT NOT PERFECTLY SO.

2326
01:44:07,494 --> 01:44:09,263
WE DON'T KNOW WHETHER PEOPLE

2327
01:44:09,263 --> 01:44:12,399
WILL ACCEPT IT OR WHAT THE

2328
01:44:12,399 --> 01:44:14,735
CONSEQUENCES ARE OF THAT.

2329
01:44:14,735 --> 01:44:17,671
IT'S ALSO A MOVING TARGET AS THE

2330
01:44:17,671 --> 01:44:19,540
COMPANIES CONTINUE TO REFINE THE

2331
01:44:19,540 --> 01:44:22,476
TESTS AND ALGORITHMS TO FIND A

2332
01:44:22,476 --> 01:44:25,012
POSITIVE OR NEGATIVE RESULT.

2333
01:44:25,012 --> 01:44:26,647
I JUST WANT YOU TO APPRECIATE

2334
01:44:26,647 --> 01:44:29,717
THAT AND THIS IS JUST A SUBSET.

2335
01:44:29,717 --> 01:44:32,019
-- THIS IS WHAT I COULD FIT ON

2336
01:44:32,019 --> 01:44:32,686
ONE SLIDE.

2337
01:44:32,686 --> 01:44:34,988
THEY TARGET VERY DIFFERENT

2338
01:44:34,988 --> 01:44:36,790
CANCERS WITH VERY DIFFERENT

2339
01:44:36,790 --> 01:44:38,459
TECHNOLOGIES.

2340
01:44:38,459 --> 01:44:40,928
AND I WILL TELL YOU RIGHT NOW

2341
01:44:40,928 --> 01:44:43,964
NOT A SINGLE ONE OF THESE

2342
01:44:43,964 --> 01:44:45,499
TECHNOLOGIES HAS BEEN VALIDATED.

2343
01:44:45,499 --> 01:44:49,737
SHOWN TO SAVE A SINGLE LIFE.

2344
01:44:49,737 --> 01:44:51,338
NOT A SINGLE ONE.

2345
01:44:51,338 --> 01:44:53,707
AND I'M GOING TO PAUSE THERE FOR

2346
01:44:53,707 --> 01:44:56,744
A MOMENT TO LET THAT SETTLE IN.

2347
01:44:56,744 --> 01:44:58,746
VERY EXCITING BUT UNPROVEN

2348
01:44:58,746 --> 01:45:02,916
TECHNOLOGY.

2349
01:45:02,916 --> 01:45:06,286
THERE ARE MANY UNKNOWNS ABOUT

2350
01:45:06,286 --> 01:45:08,021
SCREENING WITH THESE

2351
01:45:08,021 --> 01:45:08,856
TECHNOLOGIES INCLUDING

2352
01:45:08,856 --> 01:45:12,393
POPULATION BENEFITS AND HARMS.

2353
01:45:12,393 --> 01:45:15,996
IT'S UNKNOWN IF SCREENING A

2354
01:45:15,996 --> 01:45:19,566
POPULATION OF HEALTHY PEOPLE FOR

2355
01:45:19,566 --> 01:45:24,738
CANCER WITH MCED ASSAYS WILL

2356
01:45:24,738 --> 01:45:27,608
RESULT IN REDUCTION OF

2357
01:45:27,608 --> 01:45:29,510
MORTALITIES.

2358
01:45:29,510 --> 01:45:31,078
DOES THIS SAVE LIVES AND THERE

2359
01:45:31,078 --> 01:45:32,546
IS NO ANSWER FOR THAT.

2360
01:45:32,546 --> 01:45:36,417
HERE ARE SOME POTENTIAL HARMS.

2361
01:45:36,417 --> 01:45:37,851
OR UNKNOWNS.

2362
01:45:37,851 --> 01:45:39,820
WHAT KIND AND HOW MANY

2363
01:45:39,820 --> 01:45:42,923
DIAGNOSTIC TESTS ARE NEEDED.

2364
01:45:42,923 --> 01:45:46,660
WHAT HAPPENS IF THE TO POSITIVE

2365
01:45:46,660 --> 01:45:48,695
TEST DOESN'T FIND CANCER?

2366
01:45:48,695 --> 01:45:50,130
HOW MANY PEOPLE WILL BE

2367
01:45:50,130 --> 01:45:51,932
SUBJECTED TO UNNECESSARY

2368
01:45:51,932 --> 01:45:53,167
INVASIVE PROCEDURES AND SUFFER

2369
01:45:53,167 --> 01:45:56,837
FROM VARIOUS COME REPLICATIONS

2370
01:45:56,837 --> 01:45:58,872
FROM THOSE PROCEDURES.

2371
01:45:58,872 --> 01:46:00,908
WILL PEOPLE STOP TAKING STANDARD

2372
01:46:00,908 --> 01:46:04,011
OF CARE SCREENING WHICH WE KNOW

2373
01:46:04,011 --> 01:46:07,548
REDUCES MORTALITY IF THEY GET A

2374
01:46:07,548 --> 01:46:10,484
NEGATIVE MCED TEST.

2375
01:46:10,484 --> 01:46:11,985
WILL THE BLOOD TEST MAKE

2376
01:46:11,985 --> 01:46:16,824
SCREENING MORE ACCESSIBLE OR

2377
01:46:16,824 --> 01:46:19,259
EXACERBATES -- DISPARITIES.

2378
01:46:22,996 --> 01:46:24,965
THESE ARE CANCERS THAT IN A

2379
01:46:24,965 --> 01:46:26,333
PERSON'S LIFETIME WOULD NEVER

2380
01:46:26,333 --> 01:46:28,235
KILL THEM AND IF WE DIDN'T

2381
01:46:28,235 --> 01:46:30,404
DETECT THEM THE PERSON WOULD BE

2382
01:46:30,404 --> 01:46:31,839
BETTER OFF ALL AROUND BECAUSE

2383
01:46:31,839 --> 01:46:37,845
IT'S NOT GOING TO KILL THEM.

2384
01:46:37,845 --> 01:46:41,348
SO WE'RE CONSIDERING A LARGE

2385
01:46:41,348 --> 01:46:45,185
RANDOMIZED CLINICAL TRIAL.

2386
01:46:45,185 --> 01:46:47,287
THIS WOULD AT LEAST START OFF WE

2387
01:46:47,287 --> 01:46:49,790
THINK WITH TWO ASSAYS THAT ARE

2388
01:46:49,790 --> 01:46:53,393
THE FURTHEST ALONG AND EACH

2389
01:46:53,393 --> 01:46:56,997
WOULD BE ITS OWN STUDY AND

2390
01:46:56,997 --> 01:46:59,566
COMPARED TO THE STANDARD OF CARE

2391
01:46:59,566 --> 01:47:01,435
SCREENING ARM.

2392
01:47:01,435 --> 01:47:03,203
SO EVERYBODY GETS STANDARD OF

2393
01:47:03,203 --> 01:47:04,571
CARE.

2394
01:47:04,571 --> 01:47:07,174
AND THEN THEY GET TWO DIFFERENT

2395
01:47:07,174 --> 01:47:08,675
MULTI-CANCER EARLY DETECTION AND

2396
01:47:08,675 --> 01:47:13,347
BECAUSE THIS IS A PLATFORM --

2397
01:47:13,347 --> 01:47:14,548
RANDOMIZED CONTROLLED TRIAL

2398
01:47:14,548 --> 01:47:16,149
YOU'LL SEE WE CAN ADD ANOTHER

2399
01:47:16,149 --> 01:47:17,918
ARM TO THE TRIAL.

2400
01:47:17,918 --> 01:47:26,426
IF ANOTHER ONE EMERGES.

2401
01:47:26,426 --> 01:47:28,829
BUT IF WE HAVE GOT TWO OR THREE

2402
01:47:28,829 --> 01:47:30,898
OF THESE IN THE MARKET WE WOULD

2403
01:47:30,898 --> 01:47:32,799
KNOW THEN WHAT SURROGATES ARE

2404
01:47:32,799 --> 01:47:37,571
AND WE CAN MAKE SIMPLER TRIALS

2405
01:47:37,571 --> 01:47:40,240
TO EVALUATE THESE TECHNOLOGIES.

2406
01:47:40,240 --> 01:47:43,577
THIS IS JUST TO ILLUSTRATE THAT

2407
01:47:43,577 --> 01:47:47,147
THEY TARGET DIFFERENT CANCERS SO

2408
01:47:47,147 --> 01:47:53,554
THEY ARE NOT -- DIRECTLY

2409
01:47:53,554 --> 01:47:55,589
APPLICABLE.

2410
01:47:55,589 --> 01:47:59,126
IT'S THE OVER-ALL CANCER

2411
01:47:59,126 --> 01:48:01,595
MORTALITY REDUCTION THAT WE'RE

2412
01:48:01,595 --> 01:48:03,463
MEASURING.

2413
01:48:03,463 --> 01:48:05,365
SO THIS IS PART OF A BIGGER

2414
01:48:05,365 --> 01:48:07,868
PROGRAM.

2415
01:48:07,868 --> 01:48:10,337
AND WE'RE GOING TO MAKE

2416
01:48:10,337 --> 01:48:13,073
INVESTMENTS INTO UNDERSTANDING 9

2417
01:48:13,073 --> 01:48:14,775
BIOLOGY OF THESE MARKERS.

2418
01:48:14,775 --> 01:48:17,644
DO THEY DO IT FOR EVERYBODY?

2419
01:48:17,644 --> 01:48:19,446
AND ALSO TO UNDERSTAND THE

2420
01:48:19,446 --> 01:48:20,881
NATURAL HISTORY.

2421
01:48:20,881 --> 01:48:23,183
THESE BIG COHORT STUDIES.

2422
01:48:23,183 --> 01:48:25,385
WE CAN UNDERSTAND WHEN THESE

2423
01:48:25,385 --> 01:48:27,955
MARKERS TURN ON PRIOR TO A

2424
01:48:27,955 --> 01:48:29,690
CANCER DIAGNOSIS WITHOUT DOING A

2425
01:48:29,690 --> 01:48:30,958
CLINICAL TRIAL.

2426
01:48:30,958 --> 01:48:32,626
AND THEN THESE SAME COHORTS

2427
01:48:32,626 --> 01:48:34,828
COULD BE USED FOR VALIDATION OF

2428
01:48:34,828 --> 01:48:37,898
SOME OF THE TECHNOLOGIES.

2429
01:48:37,898 --> 01:48:39,166
WE'RE DEVELOPING A REFERENCE SET

2430
01:48:39,166 --> 01:48:41,001
TO CONFIRM PERFORMANCE BEFORE

2431
01:48:41,001 --> 01:48:42,936
THEY GO INTO HUMANS AND THEN I

2432
01:48:42,936 --> 01:48:45,172
WANT TO CALL OUT OUR BIOMARKERS

2433
01:48:45,172 --> 01:48:46,473
GROUP BECAUSE THEY'VE BEEN

2434
01:48:46,473 --> 01:48:48,075
INVOLVED IN THIS AREA FOR FIVE

2435
01:48:48,075 --> 01:48:52,312
YEARS THROUGH A LIQUID BIOPSY

2436
01:48:52,312 --> 01:48:52,713
CONSORTIUM.

2437
01:48:52,713 --> 01:48:54,715
THE DIVISION OF CANCER

2438
01:48:54,715 --> 01:48:56,583
PREVENTION HAS BEEN SUPPORTING

2439
01:48:56,583 --> 01:48:58,285
THE TECHNOLOGY DEVELOPMENT FOR A

2440
01:48:58,285 --> 01:48:59,853
FEW YEARS.

2441
01:48:59,853 --> 01:49:02,289
AND THEN THE RANDOMIZED CONTROL

2442
01:49:02,289 --> 01:49:05,425
TRIAL THAT I DISCUSSED -- NOW IF

2443
01:49:05,425 --> 01:49:10,964
ANY OF THEM WORK -- IT'S REALLY

2444
01:49:10,964 --> 01:49:12,966
A LUNAR LANDING FOR US BECAUSE

2445
01:49:12,966 --> 01:49:16,870
WE'RE GOING TO SEE CANCERS AT

2446
01:49:16,870 --> 01:49:18,538
STAGES WE'VE NEVER SEEN THEM

2447
01:49:18,538 --> 01:49:20,140
BEFORE BECAUSE WE DON'T HAVE

2448
01:49:20,140 --> 01:49:22,542
SCREENING TESTS FOR MANY OF

2449
01:49:22,542 --> 01:49:25,412
THESE CANCERS SO THAT WILL FUEL

2450
01:49:25,412 --> 01:49:26,880
PRECLINICAL DEVELOPMENT OF BASIC

2451
01:49:26,880 --> 01:49:31,418
AND PRECLINICAL DEVELOPMENT THAT

2452
01:49:31,418 --> 01:49:34,788
MAY LEAD TO NEW THERAPIES.

2453
01:49:34,788 --> 01:49:37,257
WE MIGHT DEVELOP THERAPIES THAT

2454
01:49:37,257 --> 01:49:39,393
WOULD PREVENT PROGRESSION TO

2455
01:49:39,393 --> 01:49:43,397
LATE STAGE CANCER THAT WOULD BE

2456
01:49:43,397 --> 01:49:44,531
MUCH MORE TARGETED.

2457
01:49:44,531 --> 01:49:46,533
SO IT WILL DRIVE A TREMENDOUS

2458
01:49:46,533 --> 01:49:48,335
AMOUNT OF INNOVATION IF THEY

2459
01:49:48,335 --> 01:49:50,137
WORK.

2460
01:49:50,137 --> 01:49:51,838
BIG CAVEATS.

2461
01:49:51,838 --> 01:49:54,074
WE DON'T KNOW IF THEY WILL WORK

2462
01:49:54,074 --> 01:49:56,743
BUT IF THEY DO THE BIG IMPACT

2463
01:49:56,743 --> 01:49:59,212
WILL BE DOWNSTREAM.

2464
01:49:59,212 --> 01:50:01,948
THE LUNAR LANDING -- IF I THINK

2465
01:50:01,948 --> 01:50:03,617
ABOUT GOING TO THE MOON THAT IS

2466
01:50:03,617 --> 01:50:04,051
INCREDIBLE.

2467
01:50:04,051 --> 01:50:14,561
THINK ABOUT IT 50 YEARS AGO --

2468
01:50:15,796 --> 01:50:18,098
SO I THINK IT COULD BE QUITE

2469
01:50:18,098 --> 01:50:21,101
LIKE THAT.

2470
01:50:21,101 --> 01:50:24,871
SO I WANT TO HIGHLIGHT SOME

2471
01:50:24,871 --> 01:50:27,808
ADDITIONAL PRIORITIES.

2472
01:50:27,808 --> 01:50:30,844
AS I SAID WE SPEND A LOT OF TIME

2473
01:50:30,844 --> 01:50:32,546
THINKING ABOUT BIOLOGICAL AND

2474
01:50:32,546 --> 01:50:35,015
POPULATION RISKS AND HOW THAT

2475
01:50:35,015 --> 01:50:36,550
INFORMS INTERVENTIONS SO WE

2476
01:50:36,550 --> 01:50:39,252
COULD BE MUCH MORE TARGETED AND

2477
01:50:39,252 --> 01:50:40,954
THEREFORE HAVE BETTER BENEFITS

2478
01:50:40,954 --> 01:50:42,889
TO HARMS TO THOSE THAT WE DO

2479
01:50:42,889 --> 01:50:43,990
INTERVENE ON.

2480
01:50:43,990 --> 01:50:47,928
OBESITY REMAINS A PLAGUE IN

2481
01:50:47,928 --> 01:50:49,763
WESTERN COUNTRIES PARTICULARLY

2482
01:50:49,763 --> 01:50:52,365
THE UNITED STATES AND CERTAINLY

2483
01:50:52,365 --> 01:50:54,835
CONTRIBUTES TO THE BURDEN OF

2484
01:50:54,835 --> 01:50:56,570
CANCER BUT WE DON'T KNOW HOW AND

2485
01:50:56,570 --> 01:50:57,704
WHY.

2486
01:50:57,704 --> 01:50:59,606
IF WE COULD WE COULD MITIGATE

2487
01:50:59,606 --> 01:51:00,874
THE EFFECTS.

2488
01:51:00,874 --> 01:51:04,478
WE SHOULD NOT RELY TOTALLY ON

2489
01:51:04,478 --> 01:51:05,712
BEHAVIORAL INTERVENTIONS TO

2490
01:51:05,712 --> 01:51:07,781
ACHIEVE THIS GOAL AND EVEN IF WE

2491
01:51:07,781 --> 01:51:11,451
COULD THERE ARE COHORTS THAT --

2492
01:51:11,451 --> 01:51:13,186
GENERATIONS OF PEOPLE THAT HAVE

2493
01:51:13,186 --> 01:51:16,423
BEEN EXPOSED TO OBESITY FOR

2494
01:51:16,423 --> 01:51:17,390
DECADES AND THE EFFECT THAT'S

2495
01:51:17,390 --> 01:51:18,792
ARE ALREADY IN PLACE SO WE HAVE

2496
01:51:18,792 --> 01:51:21,528
TO COME UP WITH STRATEGIES THAT

2497
01:51:21,528 --> 01:51:23,897
ADDRESS THE DOWNSTREAM EFFECTS

2498
01:51:23,897 --> 01:51:26,566
OF OBESITY.

2499
01:51:26,566 --> 01:51:28,535
HEALTH DISPARITIES ARE NEAR AND

2500
01:51:28,535 --> 01:51:29,269
DEAR TO ME.

2501
01:51:29,269 --> 01:51:33,473
I'VE BEEN WORKING IN MISSISSIPPI

2502
01:51:33,473 --> 01:51:35,642
FOR YEARS AND THE IDEA OF

2503
01:51:35,642 --> 01:51:38,044
BUNDLING INTERVENTIONS TO REACH

2504
01:51:38,044 --> 01:51:40,147
THE UNDERSERVED POPULATIONS IS

2505
01:51:40,147 --> 01:51:44,551
NEAR AND DEAR TO MY HEART.

2506
01:51:44,551 --> 01:51:47,988
I THINK I'VE MADE THIS POINT --

2507
01:51:47,988 --> 01:51:50,557
THE IMPORTANCE OF SYMPTOM

2508
01:51:50,557 --> 01:51:55,128
SCIENCE AND PRECISION SYMPTOM

2509
01:51:55,128 --> 01:51:57,230
MANAGEMENT.

2510
01:51:57,230 --> 01:52:00,300
TO UNDERSTAND WHAT CAUSES

2511
01:52:00,300 --> 01:52:01,735
SYMPTOMS DUE TOO CANCER AND

2512
01:52:01,735 --> 01:52:02,169
TREATMENT.

2513
01:52:02,169 --> 01:52:05,772
BASED ON THAT BIOLOGY CAN WE

2514
01:52:05,772 --> 01:52:07,741
IDENTIFY AND REDUCE THE

2515
01:52:07,741 --> 01:52:14,514
SYMPTOMS.

2516
01:52:14,514 --> 01:52:16,616
WE ARE INUNDATED WITH NEW

2517
01:52:16,616 --> 01:52:18,552
TECHNOLOGIES MULTI-CANCER EARLY

2518
01:52:18,552 --> 01:52:20,220
DETECTION IS JUST ONE OF THOSE.

2519
01:52:20,220 --> 01:52:22,022
ARTIFICIAL INTELLIGENCE IS ONE

2520
01:52:22,022 --> 01:52:23,657
OF THOSE.

2521
01:52:23,657 --> 01:52:33,300
SYNTHETIC BIOMARKERS.

2522
01:52:33,300 --> 01:52:38,104
AND THEN I THINK IMMUNOLOGY IS

2523
01:52:38,104 --> 01:52:39,673
REALLY IMPORTANT AS ONE OF THE

2524
01:52:39,673 --> 01:52:43,743
BIG IMPACTS OF THE DISCOVERY IS

2525
01:52:43,743 --> 01:52:45,745
THAT IT TELLS US THAT THERE IS

2526
01:52:45,745 --> 01:52:46,880
SOMETHING THAT GOES WRONG WITH

2527
01:52:46,880 --> 01:52:50,417
THE IMMUNE RESPONSE TO

2528
01:52:50,417 --> 01:52:51,818
PRESHOWERSERS AND EARLY

2529
01:52:51,818 --> 01:52:52,552
MUTATIONS.

2530
01:52:52,552 --> 01:52:54,254
AND SO IF WE CAN UNDERSTAND THAT

2531
01:52:54,254 --> 01:52:56,957
WE CAN DEVELOP A WHOLE NEW ARRAY

2532
01:52:56,957 --> 01:52:59,092
OF PREVENTIVE STRATEGIES THAT

2533
01:52:59,092 --> 01:53:03,230
OVERCOME THAT IMMUNE SUPPRESSION

2534
01:53:03,230 --> 01:53:07,033
THAT PROBABLY OCCURS FAIRLY

2535
01:53:07,033 --> 01:53:08,501
EARLY.

2536
01:53:08,501 --> 01:53:10,103
THE CANCER PREVENTION

2537
01:53:10,103 --> 01:53:10,737
FELLOWSHIP.

2538
01:53:10,737 --> 01:53:14,307
I WANT TO HIGHLIGHT THAT WE HAVE

2539
01:53:14,307 --> 01:53:17,143
A 35-YEAR-OLD PROGRAM -- THAT

2540
01:53:17,143 --> 01:53:19,746
HAS TRAINED HUNDREDS OF FELLOWS

2541
01:53:19,746 --> 01:53:23,617
THAT ARE IN INFLUENTIAL

2542
01:53:23,617 --> 01:53:24,484
POSITIONS ALL OVER THE UNITED

2543
01:53:24,484 --> 01:53:25,218
STATES.

2544
01:53:25,218 --> 01:53:26,653
WE'RE VERY PROUD OF OUR FAMILY

2545
01:53:26,653 --> 01:53:28,788
AND I'M ONE OF THE GRADUATES.

2546
01:53:28,788 --> 01:53:30,724
NOW LEADING THIS DIVISION.

2547
01:53:30,724 --> 01:53:33,627
AND WE'RE GROWING IT.

2548
01:53:33,627 --> 01:53:35,562
WE'RE THINKING ABOUT

2549
01:53:35,562 --> 01:53:37,497
INTERNATIONAL PROGRAMS AND A

2550
01:53:37,497 --> 01:53:39,799
POLICY BASED FELLOWSHIP.

2551
01:53:39,799 --> 01:53:42,502
THIS IS NEAR AND DEAR TO MY

2552
01:53:42,502 --> 01:53:44,738
HEART AND I WILL BE ACTING

2553
01:53:44,738 --> 01:53:47,073
DIRECTOR FOR A SHORT PERIOD OF

2554
01:53:47,073 --> 01:53:47,841
TIME.

2555
01:53:47,841 --> 01:53:50,143
WE ARE PROUD OF THE PROGRAM AND

2556
01:53:50,143 --> 01:53:56,283
WHAT THIS COHORT OR MULTIPLE

2557
01:53:56,283 --> 01:53:59,019
COHORTS HAVE ACCOMPLISHED.

2558
01:53:59,019 --> 01:54:02,322
WITH THAT A THANK YOU SLIDE.

2559
01:54:02,322 --> 01:54:04,925
THE CARTOON SAYS I'LL HAVE AN

2560
01:54:04,925 --> 01:54:07,427
OUNCE OF PREVENTION.

2561
01:54:07,427 --> 01:54:09,863
GIVE ME A POUND PLEASE.

2562
01:54:09,863 --> 01:54:15,835
WITH THAT I'LL TAKE QUESTIONS.

2563
01:54:15,835 --> 01:54:17,370
>> BEFORE WE OPEN UP TO

2564
01:54:17,370 --> 01:54:17,971
QUESTIONS.

2565
01:54:17,971 --> 01:54:21,241
I WANT TO START OFF BY SAYING

2566
01:54:21,241 --> 01:54:22,175
THAT WAS AN EXCELLENT

2567
01:54:22,175 --> 01:54:23,510
PRESENTATION.

2568
01:54:23,510 --> 01:54:26,680
YOU PACKED THAT.

2569
01:54:26,680 --> 01:54:28,581
YOU'RE ON THE LIST OF PEOPLE

2570
01:54:28,581 --> 01:54:31,451
THAT I WOULD LIKE TO TAKE OUT TO

2571
01:54:31,451 --> 01:54:32,986
LUNCH.

2572
01:54:32,986 --> 01:54:35,021
>> YOU CANNOT TAKE ME OUT
TO

2573
01:54:35,021 --> 01:54:40,994
LUNCH BUT I WILL TAKE YOU OUT TO

2574
01:54:40,994 --> 01:54:41,461
LUNCH.

2575
01:54:41,461 --> 01:54:44,631
I'M HAPPY TO GO TO LUNCH ANY

2576
01:54:44,631 --> 01:54:45,298
TIME.

2577
01:54:45,298 --> 01:54:47,434
YOU COME BY AND I'LL TAKE YOU TO

2578
01:54:47,434 --> 01:54:50,470
LUNCH.

2579
01:54:50,470 --> 01:54:52,872
>> NICOLE, YOU GO FIRST.

2580
01:54:52,872 --> 01:54:55,742
>> THANK YOU, ANJEE AND
THANK

2581
01:54:55,742 --> 01:54:56,309
YOU, PHIL.

2582
01:54:56,309 --> 01:54:58,211
THIS WAS AN AMAZING TALK.

2583
01:54:58,211 --> 01:55:05,118
A LOT OF QUESTIONS.

2584
01:55:05,118 --> 01:55:07,454
>> I WORK FOR THE AMERICAN
BRAIN

2585
01:55:07,454 --> 01:55:08,855
TUMOR ASSOCIATION.

2586
01:55:08,855 --> 01:55:11,758
AND JUST SOME OF THE THINGS THAT

2587
01:55:11,758 --> 01:55:12,692
YOU WERE TALKING ABOUT

2588
01:55:12,692 --> 01:55:15,128
ESPECIALLY WITH THE EARLY

2589
01:55:15,128 --> 01:55:18,832
DETECTION MCED TEST.

2590
01:55:18,832 --> 01:55:20,433
IT'S BEEN SOMETHING THAT OUR

2591
01:55:20,433 --> 01:55:22,068
ORGANIZATION HAS BEEN TALKING

2592
01:55:22,068 --> 01:55:24,137
ABOUT BECAUSE BRAIN TUMORS DON'T

2593
01:55:24,137 --> 01:55:24,671
HAVE SCREENING.

2594
01:55:24,671 --> 01:55:27,273
WE DON'T HAVE PREVENTION.

2595
01:55:27,273 --> 01:55:30,910
THE ONLY RISK FACTOR IS IONIZING

2596
01:55:30,910 --> 01:55:32,112
RADIATION.

2597
01:55:32,112 --> 01:55:36,049
SO IT'S CHALLENGING WHEN WE HAVE

2598
01:55:36,049 --> 01:55:37,884
PATIENTS THAT COME TO US WITH

2599
01:55:37,884 --> 01:55:40,487
HOW DID THIS HAPPEN?

2600
01:55:40,487 --> 01:55:42,455
HOW DID THIS HAPPEN?

2601
01:55:42,455 --> 01:55:43,990
WHAT CAUSED THIS?

2602
01:55:43,990 --> 01:55:45,992
NO WARNING UNTIL THEY HAVE

2603
01:55:45,992 --> 01:55:47,394
SYMPTOMS OF A CESAR.

2604
01:55:47,394 --> 01:55:50,830
SO SOMETHING LIKE THIS * WOULD

2605
01:55:50,830 --> 01:55:53,066
BE A HUGE GAME CHANGER IN THE

2606
01:55:53,066 --> 01:55:55,335
BRAIN TUMOR SPACE AND WE SAW A

2607
01:55:55,335 --> 01:55:57,504
POSTER FROM A COMPANY THAT WAS

2608
01:55:57,504 --> 01:56:01,074
PRESENTING THIS AND THEY HAD A

2609
01:56:01,074 --> 01:56:05,879
COHORT OF 2094 PATIENTS AND 247

2610
01:56:05,879 --> 01:56:07,614
OF THOSE WERE BRAIN CANCER

2611
01:56:07,614 --> 01:56:10,116
PATIENTS.

2612
01:56:10,116 --> 01:56:13,820
JUST SEEING THAT GOT US EXCITED

2613
01:56:13,820 --> 01:56:16,289
BUT APPRECIATE YOUR LEVERAGING

2614
01:56:16,289 --> 01:56:20,260
EXPECTATIONS OF JUST TRYING TO

2615
01:56:20,260 --> 01:56:24,464
SET THOSE -- NOT RED FLAGS BUT

2616
01:56:24,464 --> 01:56:26,533
BEING CURBS THAT THIS HAS NOT

2617
01:56:26,533 --> 01:56:30,303
BEEN PROVEN TO EXTEND LIVES IN

2618
01:56:30,303 --> 01:56:31,538
ANY WAY YET.

2619
01:56:31,538 --> 01:56:34,741
AND WE'RE CAUTIOUSLY HOPING THAT

2620
01:56:34,741 --> 01:56:36,342
THERE IS GOING TO BE SOMETHING

2621
01:56:36,342 --> 01:56:38,778
POSITIVE COMING FROM THIS

2622
01:56:38,778 --> 01:56:41,948
BECAUSE IT COULD BE A BRAIN

2623
01:56:41,948 --> 01:56:43,216
CHANGER.

2624
01:56:43,216 --> 01:56:45,085
-- GAME CHANGER FOR BRAIN

2625
01:56:45,085 --> 01:56:45,985
PATIENTS.

2626
01:56:45,985 --> 01:56:47,787
>> THIS IS A GOOD
ILLUSTRATION

2627
01:56:47,787 --> 01:56:50,023
THAT DETECTION OF BRAIN CANCER

2628
01:56:50,023 --> 01:56:53,326
IS NOT THE SAME AS BENEFITING

2629
01:56:53,326 --> 01:56:54,627
BRAIN CANCER PATIENTS AND THIS

2630
01:56:54,627 --> 01:56:57,864
IS ALSO NEAR AND DEAR TO MY

2631
01:56:57,864 --> 01:57:01,634
HEART -- MY MOTHER DIED OF BRAIN

2632
01:57:01,634 --> 01:57:05,205
CANCER AT AGE 35 SO I GET IT.

2633
01:57:05,205 --> 01:57:07,574
I REALLY DO.

2634
01:57:07,574 --> 01:57:11,144
>> I'M SORRY TO HEAR THAT.

2635
01:57:11,144 --> 01:57:13,980
>> AND A LONG THE LINES OF
BRAIN

2636
01:57:13,980 --> 01:57:15,682
TUMORS WE ALSO HAVE A LOT OF

2637
01:57:15,682 --> 01:57:17,584
PATIENTS AND THIS IS DIFFERENT

2638
01:57:17,584 --> 01:57:20,587
FROM OTHER CANCERS THAT HAVE

2639
01:57:20,587 --> 01:57:21,921
NONMALIGNANT BRAIN TUMORS.

2640
01:57:21,921 --> 01:57:26,860
AND WE DON'T CALL THEM MALIGN

2641
01:57:26,860 --> 01:57:31,164
FOR A REASON -- BENIGN FOR A

2642
01:57:31,164 --> 01:57:33,900
REASON.

2643
01:57:33,900 --> 01:57:37,737
* I'M WONDERING IF THESE KIND OF

2644
01:57:37,737 --> 01:57:41,808
TESTS WOULD BE ABLE TO DETECT

2645
01:57:41,808 --> 01:57:45,345
NONMALIGNANT AS WELL ASTHMA

2646
01:57:45,345 --> 01:57:46,880
LIGAMENT TUMORS *.

2647
01:57:46,880 --> 01:57:47,881
I'M CURIOUS.

2648
01:57:47,881 --> 01:57:49,983
AS I DON'T KNOW HOW THEY ARE

2649
01:57:49,983 --> 01:57:52,285
DETECTING.

2650
01:57:52,285 --> 01:57:53,486
BUZZ ANY INDICATION?

2651
01:57:53,486 --> 01:57:54,854
>> IT'S A GOOD RESEARCH
QUESTION

2652
01:57:54,854 --> 01:57:59,025
BECAUSE I COULD GET -- WE WOULD

2653
01:57:59,025 --> 01:58:02,028
NOT BE ABLE TO PROVE IN EITHER

2654
01:58:02,028 --> 01:58:03,963
CASES WE BENEFITED THE

2655
01:58:03,963 --> 01:58:04,931
POPULATION BUT THE FIRST THING

2656
01:58:04,931 --> 01:58:08,601
IS CAN YOU IDENTIFY BLOOD

2657
01:58:08,601 --> 01:58:09,836
SIGNATURES THAT ARE DIFFERENT

2658
01:58:09,836 --> 01:58:11,137
BETWEEN THE TWO.

2659
01:58:11,137 --> 01:58:13,873
THAT IS A GREAT STARTING POINT.

2660
01:58:13,873 --> 01:58:16,543
I'M GOING TO MAKE A NOTE OF THAT

2661
01:58:16,543 --> 01:58:20,680
BECAUSE IT'S A GOOD QUESTION.

2662
01:58:20,680 --> 01:58:22,515
CANCERRERS OF THE BRAIN.

2663
01:58:22,515 --> 01:58:27,053
TUMOR -- MALIGNANT VERSUS

2664
01:58:27,053 --> 01:58:29,222
BENIGN.

2665
01:58:29,222 --> 01:58:30,723
AND I DON'T KNOW.

2666
01:58:30,723 --> 01:58:35,562
ONE OF THE KEY THINGS THAT

2667
01:58:35,562 --> 01:58:37,130
PROBABLY WOULD FUEL THIS IS

2668
01:58:37,130 --> 01:58:38,998
CREATE AN A APPROPRIATE BIOBANK

2669
01:58:38,998 --> 01:58:40,300
THAT RESEARCHERS COULD COME IN

2670
01:58:40,300 --> 01:58:40,967
AND COMPANY THAT.

2671
01:58:40,967 --> 01:58:43,169
BECAUSE YOU'RE PROBABLY

2672
01:58:43,169 --> 01:58:45,538
CONNECTED TO COHORTS THAT THE

2673
01:58:45,538 --> 01:58:47,807
AVERAGE RESEARCHER WOULD NOT

2674
01:58:47,807 --> 01:58:56,683
EVEN KNOW WHAT DOOR TO KNOCK ON.

2675
01:58:56,683 --> 01:58:56,983
>> GREAT.

2676
01:58:56,983 --> 01:58:59,085
I WOULD LOVE TO JOIN YOU AND

2677
01:58:59,085 --> 01:59:03,189
ANJEE AT LUNCH.

2678
01:59:03,189 --> 01:59:09,229
>> AND MY HAND WAS UP NOT
TO

2679
01:59:09,229 --> 01:59:13,967
JUST GET IN ON THE FREE LUNCH --

2680
01:59:13,967 --> 01:59:17,637
THANK YOU AGAIN DR. CASTLE --

2681
01:59:17,637 --> 01:59:18,938
>> JUST PHIL PLEASE.

2682
01:59:18,938 --> 01:59:20,506
>> THANK YOU SO MUCH.

2683
01:59:20,506 --> 01:59:24,711
I SPOKE RECENTLY AND A COMMENT

2684
01:59:24,711 --> 01:59:26,045
AND THEN A QUESTION.

2685
01:59:26,045 --> 01:59:31,985
I SPOKE RECENTLY -- AND FROM MY

2686
01:59:31,985 --> 01:59:33,686
PERSPECTIVE -- I WOULD RATHER

2687
01:59:33,686 --> 01:59:37,657
NOT HAVE THE CANCER SO

2688
01:59:37,657 --> 01:59:39,859
PREVENTION IS IDEAL AND THEN THE

2689
01:59:39,859 --> 01:59:42,495
NEXT WOULD BE I WOULD WANTED

2690
01:59:42,495 --> 01:59:44,430
EARLY DETECTION.

2691
01:59:44,430 --> 01:59:48,034
AND THEN BARRING THAT I WANT

2692
01:59:48,034 --> 01:59:53,740
DETECTION SO HOPEFULLY THERE ARE

2693
01:59:53,740 --> 01:59:58,278
INTERVENTIONS THAT CONTROL.

2694
01:59:58,278 --> 02:00:02,048
PREVENTION IS REALLY THE HOLY

2695
02:00:02,048 --> 02:00:02,248
GRAIL.

2696
02:00:02,248 --> 02:00:04,384
FROM THE OVARIAN CANCER

2697
02:00:04,384 --> 02:00:06,052
COMMUNITY AND WE'VE HAD A LOT OF

2698
02:00:06,052 --> 02:00:08,388
DIRECT TO CONSUMER MARKETING

2699
02:00:08,388 --> 02:00:10,923
THINGS THAT WERE NOT READY FOR

2700
02:00:10,923 --> 02:00:12,925
PRIME TIME AND ONE OF THE THINGS

2701
02:00:12,925 --> 02:00:16,229
THAT COMES TO MIND -- WE'RE ALL

2702
02:00:16,229 --> 02:00:18,798
EXCITED ABOUT THESE MULTI-CANCER

2703
02:00:18,798 --> 02:00:22,335
PANELS AND ASSAYS BUT WE'RE

2704
02:00:22,335 --> 02:00:23,736
DISCOVERING THAT THERE WAS A

2705
02:00:23,736 --> 02:00:30,910
HUGE -- EARLY DETECTION TYPE OF

2706
02:00:30,910 --> 02:00:33,880
SCREENING -- APPROACH WHERE

2707
02:00:33,880 --> 02:00:42,755
THERE WAS A STAGE SHIFT --

2708
02:00:42,755 --> 02:00:46,225
>> THAT IS A GREAT EXAMPLE
OF --

2709
02:00:46,225 --> 02:00:48,928
A LOT OF PEOPLE ARE SAYING THEY

2710
02:00:48,928 --> 02:00:51,064
WANT THE REDUCTION OF THE

2711
02:00:51,064 --> 02:00:53,266
ADVANCED CANCER AS THE EARLY END

2712
02:00:53,266 --> 02:00:55,401
POINT AND WE'RE SAYING NO.

2713
02:00:55,401 --> 02:00:57,203
YOU HAVE TO SHOW MORTALITY

2714
02:00:57,203 --> 02:00:57,670
BENEFIT.

2715
02:00:57,670 --> 02:01:00,773
IF YOU'VE HOPE MORTALITY BENEFIT

2716
02:01:00,773 --> 02:01:03,042
THEN YOU CAN DO SURROGATES.

2717
02:01:03,042 --> 02:01:05,311
BUT UNTIL YOU VALIDATE THE

2718
02:01:05,311 --> 02:01:07,180
SURROGATES WE DON'T THINK SO.

2719
02:01:07,180 --> 02:01:08,981
>> AND THE AUTHORS CAME
AND

2720
02:01:08,981 --> 02:01:11,417
SPOKE TO THE COMMUNITY ABOUT THE

2721
02:01:11,417 --> 02:01:14,787
LEAD TIME THAT YOU WOULD PLEAD

2722
02:01:14,787 --> 02:01:16,889
TO HAVE AND I THINK IT WAS LIKE

2723
02:01:16,889 --> 02:01:19,492
SEVEN YEARS.

2724
02:01:19,492 --> 02:01:21,127
AND WE DON'T EVEN KNOW WHERE

2725
02:01:21,127 --> 02:01:22,762
THAT IS GOING TO BE AND HOW TO

2726
02:01:22,762 --> 02:01:25,031
FIND IT AND HOW TO INTERVENE.

2727
02:01:25,031 --> 02:01:28,534
SO MY QUESTION TO YOU -- IS ALSO

2728
02:01:28,534 --> 02:01:32,772
ARE THE MULTI-PANEL -- TESTS DO

2729
02:01:32,772 --> 02:01:35,975
THEY HAVE THE SAME SENSITIVITY

2730
02:01:35,975 --> 02:01:39,078
AND SPECIFICITY THRESHOLDS THAT

2731
02:01:39,078 --> 02:01:41,280
WE HEAR FOR SPECIFIC CANCER

2732
02:01:41,280 --> 02:01:42,448
TESTS?

2733
02:01:42,448 --> 02:01:44,317
HOW DOES THAT WORK?

2734
02:01:44,317 --> 02:01:46,953
>> FIRST OF ALL WE KNOW
VERY A

2735
02:01:46,953 --> 02:01:50,656
LITTLE.

2736
02:01:50,656 --> 02:01:53,059
THERE IT IS INTELLECTUAL

2737
02:01:53,059 --> 02:01:54,093
PROPERTY THAT THEY PROTECT.

2738
02:01:54,093 --> 02:01:56,295
SO WE DON'T KNOW WHAT THEY ARE

2739
02:01:56,295 --> 02:01:58,231
DETECTING AND THERE IS SO LITTLE

2740
02:01:58,231 --> 02:02:01,067
DATA -- AND IN CASE OF OVARIAN

2741
02:02:01,067 --> 02:02:03,870
WHAT WOULD YOU COMPARE IT TO?

2742
02:02:03,870 --> 02:02:06,139
AND COMPARING IT TO PEOPLE WHO

2743
02:02:06,139 --> 02:02:07,540
ALREADY HAVE CANCER WHICH WE

2744
02:02:07,540 --> 02:02:09,776
KNOW IS NOT THE GOAL HERE.

2745
02:02:09,776 --> 02:02:14,514
AND EVEN THE CHALLENGE OF A A

2746
02:02:14,514 --> 02:02:16,182
CROSS-SECTIONAL STUDY -- THE

2747
02:02:16,182 --> 02:02:18,351
EARLY CANCERS THAT YOU WOULD --

2748
02:02:18,351 --> 02:02:22,488
EARLY OVARIAN CANCERS -- ARE

2749
02:02:22,488 --> 02:02:24,424
THOSE THE ONE THAT'S KILL

2750
02:02:24,424 --> 02:02:25,224
PEOPLE?

2751
02:02:25,224 --> 02:02:27,427
PROBABLY NOT AND WHY WERE THEY

2752
02:02:27,427 --> 02:02:29,028
FOUND IN THE FIRST PLACE.

2753
02:02:29,028 --> 02:02:32,198
USUALLY YOU FIND 3/4.

2754
02:02:32,198 --> 02:02:35,168
SO YOU HAVE TO BE VERY CAREFUL

2755
02:02:35,168 --> 02:02:36,736
AND YOU HAVE TO BE KNOWLEDGEABLE

2756
02:02:36,736 --> 02:02:38,371
-- CONSUMERS ABOUT THIS

2757
02:02:38,371 --> 02:02:42,408
TECHNOLOGY BECAUSE THE MARKETING

2758
02:02:42,408 --> 02:02:43,743
CAMPAIGN IS EXTREME.

2759
02:02:43,743 --> 02:02:46,279
I KNOW I'VE TALKED TO

2760
02:02:46,279 --> 02:02:47,513
RESEARCHERS WHO SAY THAT THESE

2761
02:02:47,513 --> 02:02:49,682
COMPANIES ARE GOING TO STATE

2762
02:02:49,682 --> 02:02:51,417
LEGISLATORS TRYING TO GET THIS

2763
02:02:51,417 --> 02:02:53,286
STUFF AND GOING TO CMS AND

2764
02:02:53,286 --> 02:02:55,388
TRYING TO PUSH THIS.

2765
02:02:55,388 --> 02:02:57,190
BUT HERE IS THE THING.

2766
02:02:57,190 --> 02:02:59,759
IT'S NOT A PERFECT ANALOGY BUT A

2767
02:02:59,759 --> 02:03:00,993
USEFUL ONE.

2768
02:03:00,993 --> 02:03:03,429
IF THIS WAS A DRUG THERE IS NO

2769
02:03:03,429 --> 02:03:08,134
WAY YOU WOULD BE GIVING THIS TO

2770
02:03:08,134 --> 02:03:10,436
ANYBODY BEFORE YOU DID THE

2771
02:03:10,436 --> 02:03:11,671
RANDOMIZED CONTROL TRIAL.

2772
02:03:11,671 --> 02:03:14,373
NOW I REALIZE THAT THE TEST IS

2773
02:03:14,373 --> 02:03:16,843
NOT -- YOU'RE NOT CONSUMING

2774
02:03:16,843 --> 02:03:18,744
SOMETHING BUT THE DOWNSTREAM

2775
02:03:18,744 --> 02:03:20,947
EFFECTS ARE INTERNAL.

2776
02:03:20,947 --> 02:03:23,916
YOU'RE EITHER IMAGING AND

2777
02:03:23,916 --> 02:03:25,885
RADIATION OR BIOPSIES AND

2778
02:03:25,885 --> 02:03:28,254
FINANCIAL TOXICITIES FOR LOW

2779
02:03:28,254 --> 02:03:28,988
RESOURCED PEOPLE.

2780
02:03:28,988 --> 02:03:31,824
ALL OF THESE THINGS.

2781
02:03:31,824 --> 02:03:34,594
AND SO IF WE WOULD NOT ACCEPT

2782
02:03:34,594 --> 02:03:37,763
THIS FOR A DRUG WHY WOULD WE

2783
02:03:37,763 --> 02:03:39,131
ACCEPT IT FOR ANOTHER

2784
02:03:39,131 --> 02:03:40,199
INTERVENTION?

2785
02:03:40,199 --> 02:03:41,801
DOESN'T MAKE SENSE TO ME.

2786
02:03:41,801 --> 02:03:43,703
AND LET ME BE CLEAR.

2787
02:03:43,703 --> 02:03:45,805
I'M VERY EXCITED ABOUT THEM THE

2788
02:03:45,805 --> 02:03:48,140
TOO BUT AS A PUBLIC HEALTH

2789
02:03:48,140 --> 02:03:51,677
OFFICIAL I HAVE TO PUT MY

2790
02:03:51,677 --> 02:03:53,946
EXCITEMENT ASIDE AND SAY SHOW ME

2791
02:03:53,946 --> 02:03:56,182
THE EVIDENCE.

2792
02:03:56,182 --> 02:03:58,284
SHOW ME THE DATA.

2793
02:03:58,284 --> 02:04:02,889
BECAUSE IT ISN'T ME GETTING THIS

2794
02:04:02,889 --> 02:04:04,557
INTERVENTION.

2795
02:04:04,557 --> 02:04:06,325
EVERY ONE OF THOSE PEOPLE MAY

2796
02:04:06,325 --> 02:04:08,694
WANT THAT AND IS IT GOOD FOR

2797
02:04:08,694 --> 02:04:13,165
THEM AND IS IT -- WHICH TEST

2798
02:04:13,165 --> 02:04:16,936
SHOULD IT BE.

2799
02:04:16,936 --> 02:04:21,107
SO, ITS VERY COMPLICATED

2800
02:04:21,107 --> 02:04:23,342
>> BUT THIS IS
ASYMPTOMATIC

2801
02:04:23,342 --> 02:04:25,311
GENERAL POPULATION.

2802
02:04:25,311 --> 02:04:29,916
>> EXACTLY.

2803
02:04:29,916 --> 02:04:32,184
IT COULD BE ASYMPTOMATIC BUT

2804
02:04:32,184 --> 02:04:33,519
THEY COULD BE SMOKERS.

2805
02:04:33,519 --> 02:04:36,756
SO THEY DON'T HAVE SYMPTOMS

2806
02:04:36,756 --> 02:04:40,593
RIGHT NOW BUT IS THERE A TEST

2807
02:04:40,593 --> 02:04:44,664
BETTER FOR BRCA RELATED CANCERS.

2808
02:04:44,664 --> 02:04:47,466
OVARIAN, BREAST, PANCREATIC.

2809
02:04:47,466 --> 02:04:48,668
MAYBE COLON.

2810
02:04:48,668 --> 02:04:50,536
BUT YOU GET MY IDEA.

2811
02:04:50,536 --> 02:04:52,805
THAT YOU WANT TO TAILOR THEM.

2812
02:04:52,805 --> 02:04:56,909
THE OTHER THING -- ANOTHER ARM

2813
02:04:56,909 --> 02:04:58,244
IN THE TRIAL.

2814
02:04:58,244 --> 02:05:00,913
SEVERAL GROUPS DEVELOPING A

2815
02:05:00,913 --> 02:05:02,348
SINGLE CANCER BLOOD TEST AND

2816
02:05:02,348 --> 02:05:03,916
THOSE MAY PERFORM BETTER.

2817
02:05:03,916 --> 02:05:06,986
SO WHAT IF YOU COMBINE A BUNCH

2818
02:05:06,986 --> 02:05:08,688
OF THOSE BECAUSE THEY ARE

2819
02:05:08,688 --> 02:05:11,557
FOCUSED ON A PARTICULAR TARGET.

2820
02:05:11,557 --> 02:05:14,160
WOULD THAT OUTDO THE

2821
02:05:14,160 --> 02:05:16,128
MULTI-CANCER EARLY DETECTION.

2822
02:05:16,128 --> 02:05:18,297
IT'S THE SAME SAMPLE.

2823
02:05:18,297 --> 02:05:20,499
THE SAME AMOUNT OF BLOOD BUT

2824
02:05:20,499 --> 02:05:24,136
TARGETING A SINGLE CANCER MIGHT

2825
02:05:24,136 --> 02:05:25,738
BE MORE SENSITIVE PARTICULARLY

2826
02:05:25,738 --> 02:05:27,707
FOR EARLY STAGE.

2827
02:05:27,707 --> 02:05:29,108
>> THANK YOU SO MUCH.

2828
02:05:29,108 --> 02:05:30,209
>> MY PLEASURE.

2829
02:05:30,209 --> 02:05:32,144
>> WE'RE UP TO THREE
PEOPLE FOR

2830
02:05:32,144 --> 02:05:34,280
LUNCH HERE.

2831
02:05:34,280 --> 02:05:37,650
FOUR INCLUDING ME.

2832
02:05:37,650 --> 02:05:42,088
>> I WOULD LOVE TO JOIN

2833
02:05:42,088 --> 02:05:43,923
DR. CASTLE AND WE COULD TALK TO

2834
02:05:43,923 --> 02:05:45,224
YOU FOR HOURS.

2835
02:05:45,224 --> 02:05:47,226
YOUR PRESENTATION WAS AWESOME.

2836
02:05:47,226 --> 02:05:50,162
IT WAS VERY REFRESHING AND

2837
02:05:50,162 --> 02:05:51,731
REINFORCING BECAUSE WE'RE

2838
02:05:51,731 --> 02:05:55,334
TALKING ABOUT THIS -- THE MCED

2839
02:05:55,334 --> 02:05:56,769
TOPIC A LOT.

2840
02:05:56,769 --> 02:05:59,705
THE SCIENCE IS NOT THERE YET.

2841
02:05:59,705 --> 02:06:01,674
HOW DO WE SUPPORT IT MOVING

2842
02:06:01,674 --> 02:06:05,177
FORWARD IS WHERE WE ARE.

2843
02:06:05,177 --> 02:06:06,412
TAKE MY BLOOD.

2844
02:06:06,412 --> 02:06:07,313
SIGN ME UP NOW.

2845
02:06:07,313 --> 02:06:10,082
I WOULD DO IT BUT THAT IS NOT

2846
02:06:10,082 --> 02:06:11,651
RIGHT FOR OUR SOCIETY.

2847
02:06:11,651 --> 02:06:13,552
BUT MY QUESTION IS A LITTLE

2848
02:06:13,552 --> 02:06:14,186
RANDOM.

2849
02:06:14,186 --> 02:06:17,189
AND I GUESS SHAME ON ME AGAIN.

2850
02:06:17,189 --> 02:06:20,192
I HAD NO IDEA THERE WAS

2851
02:06:20,192 --> 02:06:22,895
SELF-COLLECTED HPV TESTS

2852
02:06:22,895 --> 02:06:24,730
AVAILABLE.

2853
02:06:24,730 --> 02:06:27,333
>> WE'RE TRYING TO GET
THEM

2854
02:06:27,333 --> 02:06:28,367
AVAILABLE.

2855
02:06:28,367 --> 02:06:31,537
>> MY QUESTION TIES INTO
THE

2856
02:06:31,537 --> 02:06:33,239
REIMBURSE MEANT PIECE.

2857
02:06:33,239 --> 02:06:36,475
49 OUT OF 50 WOMEN WOULD NOT GET

2858
02:06:36,475 --> 02:06:39,478
CERVICAL CANCER IF WE DID

2859
02:06:39,478 --> 02:06:39,912
NOTHING.

2860
02:06:39,912 --> 02:06:42,782
WOULD THAT MAKE IT HARD TO GET

2861
02:06:42,782 --> 02:06:53,192
OTHER TEASERS APPROVED?

2862
02:06:56,796 --> 02:06:58,164
--

2863
02:06:58,164 --> 02:07:00,466
>> HE FIRST SAMPLED HIS
WIFE

2864
02:07:00,466 --> 02:07:01,934
WHICH NEVER WOULD HAPPEN IN

2865
02:07:01,934 --> 02:07:03,469
TODAY'S WORLD.

2866
02:07:03,469 --> 02:07:06,539
AND THEN THE AMERICAN CANCER

2867
02:07:06,539 --> 02:07:08,340
SOCIETY FIRST RECOMMENDED ANNUAL

2868
02:07:08,340 --> 02:07:10,843
PAP SMEARS IN 1951.

2869
02:07:10,843 --> 02:07:14,814
AND THAT OF COURSE

2870
02:07:14,814 --> 02:07:15,181
REVOLUTIONIZED.

2871
02:07:15,181 --> 02:07:18,150
WE WOULD NOT BE HERE WITH HPV

2872
02:07:18,150 --> 02:07:19,919
RELATED TOOLS HAD THAT NOT

2873
02:07:19,919 --> 02:07:20,586
HAPPENED.

2874
02:07:20,586 --> 02:07:24,657
SO WE WENT FROM A NOT GREAT TEST

2875
02:07:24,657 --> 02:07:26,525
TO A BETTER TEST.

2876
02:07:26,525 --> 02:07:28,661
BUT REIMBURSEMENT IS AN

2877
02:07:28,661 --> 02:07:31,297
IMPORTANT PART OF THIS.

2878
02:07:31,297 --> 02:07:34,867
NOW COMING BACK TO THE 49 AND 50

2879
02:07:34,867 --> 02:07:36,235
I ILLUSTRATE THAT.

2880
02:07:36,235 --> 02:07:38,871
WE DON'T DO CERVICAL CANCER WORK

2881
02:07:38,871 --> 02:07:40,372
TO THE END POINT OF CANCER

2882
02:07:40,372 --> 02:07:41,707
BECAUSE WE KNOW WHAT THE

2883
02:07:41,707 --> 02:07:42,374
SURROGATES ARE.

2884
02:07:42,374 --> 02:07:46,545
SO WE SHOW THAT WE CAN DETECT --

2885
02:07:46,545 --> 02:07:48,914
CN2 AND CN3.

2886
02:07:48,914 --> 02:07:51,484
SO THE TRIALS GO MUCH QUICKER

2887
02:07:51,484 --> 02:07:53,753
AND WE DON'T HAVE TO SHOW AND

2888
02:07:53,753 --> 02:07:56,155
THE TREATMENTS ARE FAIRLY BENIGN

2889
02:07:56,155 --> 02:07:58,958
AND WE'RE WORKING ON DEVELOPING

2890
02:07:58,958 --> 02:08:01,460
BETTER TREATMENTS.

2891
02:08:01,460 --> 02:08:03,462
WE CUT THE TISSUE OUT WHICH IS

2892
02:08:03,462 --> 02:08:07,733
NOT SO BAD BUT IF WE COULD DO IT

2893
02:08:07,733 --> 02:08:09,635
WITHOUT CUTTING EVEN BETTER.

2894
02:08:09,635 --> 02:08:11,403
PARTICULARLY IN THE THIRD WORLD

2895
02:08:11,403 --> 02:08:13,939
IN THE LOW AND MIDDLE INCOME

2896
02:08:13,939 --> 02:08:17,109
COUNTRIES WHICH IS WHERE I WORK.

2897
02:08:17,109 --> 02:08:19,211
SO WE DON'T HAVE TO SHOW THAT IT

2898
02:08:19,211 --> 02:08:22,848
PREVENT THAT ONE OUT OF 50

2899
02:08:22,848 --> 02:08:23,415
CANCERS.

2900
02:08:23,415 --> 02:08:25,050
PLUS WE HAVE COMPARISONS.

2901
02:08:25,050 --> 02:08:27,753
WE HAVE ALREADY KNOW WHAT TESTS

2902
02:08:27,753 --> 02:08:28,687
WORK.

2903
02:08:28,687 --> 02:08:30,890
UNLIKE IN THE MCED WHERE WE

2904
02:08:30,890 --> 02:08:33,058
DON'T HAVE A TEST THAT WE KNOW

2905
02:08:33,058 --> 02:08:33,459
WORKS.

2906
02:08:33,459 --> 02:08:36,228
ONCE WE HAVE A TEST THAT WE KNOW

2907
02:08:36,228 --> 02:08:39,265
WORKS WE CAN DO THE COMPARISONS

2908
02:08:39,265 --> 02:08:41,901
AND IT WILL SPEED IT UP.

2909
02:08:41,901 --> 02:08:45,671
HAVING A COME PETTIVE MARKET

2910
02:08:45,671 --> 02:08:48,274
BLESS IS GOOD.

2911
02:08:48,274 --> 02:08:50,543
IT KEEPS THE PRICE DOWN AND

2912
02:08:50,543 --> 02:08:59,718
EVERYONE HONEST.

2913
02:08:59,718 --> 02:09:00,553
--

2914
02:09:00,553 --> 02:09:02,154
>> AND TO YOUR POINT ABOUT
THE

2915
02:09:02,154 --> 02:09:07,226
SINGLE ORGAN OR WHATEVER TESTING

2916
02:09:07,226 --> 02:09:11,730
-- THERE ARE SOME OTHER --

2917
02:09:11,730 --> 02:09:15,067
>> LIKE DEL FINE.

2918
02:09:15,067 --> 02:09:18,704
>> I KNOW THAT WE NEED TO
CUT

2919
02:09:18,704 --> 02:09:20,272
OUR QUESTIONS IN FIVE MINUTES.

2920
02:09:20,272 --> 02:09:22,141
SO I KNOW KEVIN YOU HAVE A

2921
02:09:22,141 --> 02:09:24,677
QUESTION AND IF YOU HAVE -- IF

2922
02:09:24,677 --> 02:09:26,111
YOU CAN TYPE YOUR QUESTIONS IN

2923
02:09:26,111 --> 02:09:28,347
THE CHAT AS WELL SO IF WE DON'T

2924
02:09:28,347 --> 02:09:30,616
GET TO IT WE CAN AT LEAST TRY TO

2925
02:09:30,616 --> 02:09:34,153
GET THOSE ANSWERS FOR YOU AND I

2926
02:09:34,153 --> 02:09:35,154
HAVE A QUESTION.

2927
02:09:35,154 --> 02:09:37,690
>> ARE YOU GOING TO
COLLECT THE

2928
02:09:37,690 --> 02:09:40,359
QUESTIONS AND SEND THEM TO ME.

2929
02:09:40,359 --> 02:09:42,394
BECAUSE I'M BUSY GETTING LUNCH

2930
02:09:42,394 --> 02:09:44,964
DATES AND HAVE NOT BEEN PAYING

2931
02:09:44,964 --> 02:09:46,165
ATTENTION.

2932
02:09:46,165 --> 02:09:48,067
>> MAYBE WE CAN COLLECT
THOSE

2933
02:09:48,067 --> 02:09:49,368
FOR YOU.

2934
02:09:49,368 --> 02:09:50,903
>> I'LL CLOSE-UP THIS PART
OF

2935
02:09:50,903 --> 02:09:55,808
OUR AGENDA.

2936
02:09:55,808 --> 02:09:58,043
>> THANK YOU PHIL VERY
MUCH FOR

2937
02:09:58,043 --> 02:09:58,944
WHAT YOU HAVE TO OFFER.

2938
02:09:58,944 --> 02:10:01,280
THIS IS A TREMENDOUS VISION THAT

2939
02:10:01,280 --> 02:10:03,148
YOU OVERSEE.

2940
02:10:03,148 --> 02:10:06,785
AND A TREMENDOUS AMOUNT OF

2941
02:10:06,785 --> 02:10:08,754
PROSPECT AND HOPE MOVING

2942
02:10:08,754 --> 02:10:09,555
FORWARD.

2943
02:10:09,555 --> 02:10:11,824
SO I RELATION THE RESOURCES OF

2944
02:10:11,824 --> 02:10:14,426
WHICH YOU'RE ADVOCATING FOR BUT

2945
02:10:14,426 --> 02:10:17,763
I'M FASCINATED ALSO BY THE

2946
02:10:17,763 --> 02:10:19,365
CANCER PREVENTION FELLOWSHIP

2947
02:10:19,365 --> 02:10:23,969
PROGRAM WHICH BRINGS MORE

2948
02:10:23,969 --> 02:10:26,372
RESOURCES AND EMPLOYEES AND

2949
02:10:26,372 --> 02:10:28,474
DRIVER INTO THIS WHICH IS MORE

2950
02:10:28,474 --> 02:10:31,944
THAN JUST A DOLLAR INVESTMENT.

2951
02:10:31,944 --> 02:10:33,879
ONE QUICK QUESTION THAT I HAVE.

2952
02:10:33,879 --> 02:10:35,447
AND A LITTLE BIT AN OVERVIEW

2953
02:10:35,447 --> 02:10:36,916
SITUATION.

2954
02:10:36,916 --> 02:10:42,855
YOU TALK ABOUT IDEALLY TO HAVE

2955
02:10:42,855 --> 02:10:44,890
NO EVENT AND THAT IS IF CANCER

2956
02:10:44,890 --> 02:10:46,425
NEVER OCCURS.

2957
02:10:46,425 --> 02:10:48,527
THAT WE'RE ABLE TO BE SO

2958
02:10:48,527 --> 02:10:49,862
SUCCESSFUL IN PREVENTING THAT

2959
02:10:49,862 --> 02:10:53,032
WHICH IS A GREAT GOAL.

2960
02:10:53,032 --> 02:10:53,832
SCIENTIFICALLY WE HAVE TO PROVE

2961
02:10:53,832 --> 02:10:56,201
THE THAT AND MY QUESTION IS

2962
02:10:56,201 --> 02:10:58,637
UNDER WHAT CONDITIONS OR UNITS

2963
02:10:58,637 --> 02:11:02,374
OF MEASURE CAN YOU FIND HOW

2964
02:11:02,374 --> 02:11:04,743
SUCCESSFUL YOU ARE IN PREVENTION

2965
02:11:04,743 --> 02:11:06,712
UNDER THAT SCENARIO THAT IT DOES

2966
02:11:06,712 --> 02:11:07,746
NOT OCCUR?

2967
02:11:07,746 --> 02:11:10,082
>> THAT IS A GREAT
QUESTION,

2968
02:11:10,082 --> 02:11:13,485
CO--KEVIN.

2969
02:11:13,485 --> 02:11:15,054
THANK YOU FOR BRINGING THAT.

2970
02:11:15,054 --> 02:11:16,789
BECAUSE IT IS SUPER CHALLENGING.

2971
02:11:16,789 --> 02:11:19,224
WE DO IT THROUGH CANCER

2972
02:11:19,224 --> 02:11:20,092
REGISTRIES.

2973
02:11:20,092 --> 02:11:25,631
IF YOU LOOK AT THE -- FOR

2974
02:11:25,631 --> 02:11:28,300
CERVICAL CANCER THEY START OFF

2975
02:11:28,300 --> 02:11:30,002
HIGH AND THEY COME DOWN AND DOWN

2976
02:11:30,002 --> 02:11:31,804
AND THEY'VE LEVELED OFF AND PART

2977
02:11:31,804 --> 02:11:35,140
OF THE REASON IS THAT IT'S --

2978
02:11:35,140 --> 02:11:36,642
ALL OF THESE THINGS ARE

2979
02:11:36,642 --> 02:11:38,377
IMPERFECT AND ALSO BECAUSE WE'RE

2980
02:11:38,377 --> 02:11:40,546
NOT REACHING A SEGMENT OF THE

2981
02:11:40,546 --> 02:11:42,948
POPULATION THAT -- A SMALL

2982
02:11:42,948 --> 02:11:44,483
SEGMENT OF THE POPULATION THE

2983
02:11:44,483 --> 02:11:46,251
UNDERSERVED POPULATION THAT 50%

2984
02:11:46,251 --> 02:11:48,354
OF THOSE CANCERS OCCUR IN.

2985
02:11:48,354 --> 02:11:50,856
SO YOU USE SURVEILLANCE ON A

2986
02:11:50,856 --> 02:11:52,391
NATIONAL LEVEL TO LOOK AT

2987
02:11:52,391 --> 02:11:54,593
CHANGES.

2988
02:11:54,593 --> 02:11:57,496
OR WITHIN A PARTICULAR REGISTRY.

2989
02:11:57,496 --> 02:12:03,002
LET'S SAY SOMEBODY INTRODUCED A

2990
02:12:03,002 --> 02:12:05,938
MULTI-CANCER EARLY -- DETECTION

2991
02:12:05,938 --> 02:12:07,539
YOU COULD SEE DIFFERENCES OVER

2992
02:12:07,539 --> 02:12:09,308
TIME OR MAYBE NOT.

2993
02:12:09,308 --> 02:12:11,276
AND THAT DOES MAKE IT

2994
02:12:11,276 --> 02:12:12,678
CHALLENGING WHICH IS WHY WE'RE

2995
02:12:12,678 --> 02:12:16,015
MORE -- WE HAVE TO DO MORE

2996
02:12:16,015 --> 02:12:17,649
RANDOMIZED CONTROLLED TRIALS

2997
02:12:17,649 --> 02:12:18,817
THAN IN THE TREATMENT SPACE.

2998
02:12:18,817 --> 02:12:20,519
IN THE TREATMENT SPACE THEY DO

2999
02:12:20,519 --> 02:12:22,454
ONE ARMED TRIALS AND DOES THE

3000
02:12:22,454 --> 02:12:25,324
PATIENT SURVIVOR NOT SURVIVE AND

3001
02:12:25,324 --> 02:12:28,027
DO THEY KNOW ENOUGH ABOUT THE

3002
02:12:28,027 --> 02:12:29,695
HISTORY ABOUT THE HISTORY.

3003
02:12:29,695 --> 02:12:32,598
BUT FOR US WE HAVE TO DO

3004
02:12:32,598 --> 02:12:33,465
RANDOMIZED CONTROL TRIALS AND IN

3005
02:12:33,465 --> 02:12:35,000
THE CASE OF SCREENING TO THE

3006
02:12:35,000 --> 02:12:36,902
POINT OF CANCER MORTALITY WITHIN

3007
02:12:36,902 --> 02:12:39,138
THE TRIAL TO SHOW THAT IT WORKS.

3008
02:12:39,138 --> 02:12:42,041
THAT IS WHY IT'S SO HARD AND

3009
02:12:42,041 --> 02:12:43,242
EXPENSIVE.

3010
02:12:43,242 --> 02:12:45,711
BUT THE UPSIDE I THINK YOU CAN

3011
02:12:45,711 --> 02:12:47,513
APPRECIATE AND YOU SAID IT WELL

3012
02:12:47,513 --> 02:12:51,016
-- IS PEOPLE NEVER GET CANCER.

3013
02:12:51,016 --> 02:12:54,686
RIGHT AND THAT IS A WIN.

3014
02:12:54,686 --> 02:12:56,755
SO IT IS CHALLENGING.

3015
02:12:56,755 --> 02:12:59,224
HIGH RISK, HIGH REWARD IN

3016
02:12:59,224 --> 02:13:02,628
PREVENTION.

3017
02:13:02,628 --> 02:13:04,163
>> THANK YOU SO MUCH,
PHIL.

3018
02:13:04,163 --> 02:13:07,132
I THINK WE'RE GOING TO NEED A

3019
02:13:07,132 --> 02:13:08,267
BIGGER LUNCH TABLE

3020
02:13:08,267 --> 02:13:10,436
>> AND MORE TIME.

3021
02:13:10,436 --> 02:13:14,239
HOLLY I WANT TO THANK YOU FOR

3022
02:13:14,239 --> 02:13:22,948
BEING PATIENT WITH US.

3023
02:13:22,948 --> 02:13:25,484
I DO HOPE THAT BASED ON YOUR

3024
02:13:25,484 --> 02:13:27,920
PRESENTATION THAT WE CAN

3025
02:13:27,920 --> 02:13:29,354
SOCIALIZE SOME OF THE SYMPTOMS

3026
02:13:29,354 --> 02:13:30,522
SCIENCE THAT YOU WERE SPEAKING

3027
02:13:30,522 --> 02:13:32,391
OF AS IT RELATES TO CLINICAL

3028
02:13:32,391 --> 02:13:33,492
TRIAL DESIGN.

3029
02:13:33,492 --> 02:13:36,395
I HEAR VERY LITTLE ABOUT SYMPTOM

3030
02:13:36,395 --> 02:13:42,201
SCIENCE IN OUR CLING DA -- CLINL

3031
02:13:42,201 --> 02:13:48,373
TRIAL DISCUSSIONS.

3032
02:13:48,373 --> 02:13:51,110
I WAS THINKING -- I HOPE AS PART

3033
02:13:51,110 --> 02:13:55,781
OF YOUR LARGER TRIAL THAT AN

3034
02:13:55,781 --> 02:13:58,050
ECONOMIC STUDY IS BEING DONE.

3035
02:13:58,050 --> 02:14:03,388
AND THREE, I WAS WONDERING IF

3036
02:14:03,388 --> 02:14:06,191
FDA CMS AND OTHERS ARE

3037
02:14:06,191 --> 02:14:09,228
COORDINATING TO THINK THROUGH

3038
02:14:09,228 --> 02:14:11,897
AND THIS IS A PHIL AND HOLLY

3039
02:14:11,897 --> 02:14:14,967
QUESTION BECAUSE I'M IN

3040
02:14:14,967 --> 02:14:19,004
COLORECTAL CANCER.

3041
02:14:19,004 --> 02:14:20,606
AND I'VE NEVER SEEN A BIGGER

3042
02:14:20,606 --> 02:14:22,207
LOBBY BEHIND IT.

3043
02:14:22,207 --> 02:14:24,143
BECAUSE WHERE A POLICY AND

3044
02:14:24,143 --> 02:14:25,644
RESEARCH GROUP AND I'VE NEVER

3045
02:14:25,644 --> 02:14:28,247
SEEN SO MUCH MONEY GO BEHIND

3046
02:14:28,247 --> 02:14:30,015
LOBBYING FOR THIS AND OUR

3047
02:14:30,015 --> 02:14:32,351
BIGGEST CONCERN IS THAT IT GETS

3048
02:14:32,351 --> 02:14:34,653
A HEAD OF THE SCIENCE AND I

3049
02:14:34,653 --> 02:14:35,988
SHARE THAT CONCERN WITH YOU BUT

3050
02:14:35,988 --> 02:14:37,823
ALSO THAT THE SCIENCE IS NOT

3051
02:14:37,823 --> 02:14:40,192
GETTING OUT -- DISSEMINATING

3052
02:14:40,192 --> 02:14:42,761
FAST ENOUGH FOR ADVOCACY GROUPS

3053
02:14:42,761 --> 02:14:44,563
TO STAND STRONG ROUND THE

3054
02:14:44,563 --> 02:14:46,665
SCIENCE BECAUSE I THINK THE

3055
02:14:46,665 --> 02:14:48,901
EARLIER QUESTION ABOUT

3056
02:14:48,901 --> 02:14:52,571
SENSITIVITY -- SPEAKS SERVE IT

3057
02:14:52,571 --> 02:14:55,741
OF DATA * NEEDS TO BE AVAILABLE

3058
02:14:55,741 --> 02:14:59,244
ACROSS ALL OF THE DIFFERENT

3059
02:14:59,244 --> 02:15:05,884
OPTIONS SO THAT WE'RE NOT

3060
02:15:05,884 --> 02:15:10,222
SWAYED.

3061
02:15:10,222 --> 02:15:12,324
THOSE ARE THOUGHTS NOT

3062
02:15:12,324 --> 02:15:12,758
QUESTIONS.

3063
02:15:12,758 --> 02:15:18,564
I HOPE THAT WE CAN HAVE LUNCH

3064
02:15:18,564 --> 02:15:21,133
BECAUSE THIS IS ONE OF THE TOPIC

3065
02:15:21,133 --> 02:15:23,502
THAT'S ADVOCACY IS SO IMPORTANT

3066
02:15:23,502 --> 02:15:26,238
>> I NEED YOU MORE THAN
YOU NEED

3067
02:15:26,238 --> 02:15:26,405
ME.

3068
02:15:26,405 --> 02:15:28,607
SO I REALLY NEED YOU TO GET THE

3069
02:15:28,607 --> 02:15:30,475
WORD OUT AND ON ALL THREE OF

3070
02:15:30,475 --> 02:15:32,144
THOSE AREAS I WILL ALSO SAY THAT

3071
02:15:32,144 --> 02:15:36,748
WE'RE GOING TO HAVE -- I DON'T

3072
02:15:36,748 --> 02:15:39,851
WANT TO CALL IT PATIENTS BUT

3073
02:15:39,851 --> 02:15:42,421
PEOPLE ADVOCACY GROUPS FOR BOTH

3074
02:15:42,421 --> 02:15:44,089
THE DIVISION AND THE

3075
02:15:44,089 --> 02:15:46,024
MULTI-CANCER EARLY DETECTION

3076
02:15:46,024 --> 02:15:48,293
TRIAL AND I WOULD NEED HELP

3077
02:15:48,293 --> 02:15:49,261
POPULATING THOSE.

3078
02:15:49,261 --> 02:15:50,996
WE NEED YOUR HELP TO GET THE

3079
02:15:50,996 --> 02:15:53,232
WORD OUT AND IT'S UP TO YOU TO

3080
02:15:53,232 --> 02:15:56,268
MAKE THE DEMAND TO SAY WE NEED

3081
02:15:56,268 --> 02:15:56,668
BETTER PREVENTION.

3082
02:15:56,668 --> 02:15:59,605
THAT IS THE WAY OF WE CHANGE IT.

3083
02:15:59,605 --> 02:16:01,473
OF COURSE I'M BIASED.

3084
02:16:01,473 --> 02:16:03,909
SAYING I WANT MORE RESOURCES BUT

3085
02:16:03,909 --> 02:16:06,612
IF YOU SAY I WANT BETTER

3086
02:16:06,612 --> 02:16:08,981
PREVENTION THAT IS A STRONGER

3087
02:16:08,981 --> 02:16:09,214
MESSAGE.

3088
02:16:09,214 --> 02:16:10,616
THANK YOU VERY MUCH AND HOLLY

3089
02:16:10,616 --> 02:16:13,652
I'M SORRY I PROBABLY STOLE SOME

3090
02:16:13,652 --> 02:16:18,357
OF YOUR TIME.

3091
02:16:18,357 --> 02:16:20,993
I'L

3092
02:16:20,993 --> 02:16:26,598
>> NO PROBLEM AT ALL.

3093
02:16:26,598 --> 02:16:27,199
>> HOLLY.

3094
02:16:27,199 --> 02:16:29,401
THANK YOU FOR JOINING US.

3095
02:16:29,401 --> 02:16:31,003
YOU'RE A GOOD FRIEND OF THIS

3096
02:16:31,003 --> 02:16:32,571
COMMITTEE SO I'M GOING TO TURN

3097
02:16:32,571 --> 02:16:42,848
IT OVER TO YOU.

3098
02:16:51,490 --> 02:16:53,058
>> I WANTED TO START BY

3099
02:16:53,058 --> 02:16:56,962
RECOGNIZING A CHAMPION -- FOR

3100
02:16:56,962 --> 02:16:59,231
BIOMEDICAL RESEARCH.

3101
02:16:59,231 --> 02:17:04,836
LAWMAKERS PAY TRIBUTE --

3102
02:17:04,836 --> 02:17:06,438
CONGRESSMAN PORTER HAD SERVED AS

3103
02:17:06,438 --> 02:17:10,609
A CHAIR OF THE HOUSE COMMITTEE

3104
02:17:10,609 --> 02:17:15,814
AND LED THE --

3105
02:17:15,814 --> 02:17:17,015
[ INDISCERNIBLE ]

3106
02:17:17,015 --> 02:17:19,885
AFTER HE RETURNED HE ALSO SERVED

3107
02:17:19,885 --> 02:17:22,120
AS CHAIR FOR MANY YEARS

3108
02:17:22,120 --> 02:17:32,564
INCLUDING UP TO HIS DEATH.

3109
02:17:36,435 --> 02:17:45,811
[ INDISCERNIBLE ]

3110
02:17:45,811 --> 02:17:47,913
YOU'LL SEE HERE AT THE FIRST

3111
02:17:47,913 --> 02:17:50,349
STEP IS THE RELEASE OF THE

3112
02:17:50,349 --> 02:17:53,485
PRESIDENT'S BUDGET PROPOSAL

3113
02:17:53,485 --> 02:17:58,790
FOLLOWED BY THE APPROPRIATION.

3114
02:17:58,790 --> 02:18:01,593
THAT PROCESS IS STILL UNDERWAY.

3115
02:18:01,593 --> 02:18:03,962
THE HOUSE ALSO SLIGHTLY AHEAD OF

3116
02:18:03,962 --> 02:18:12,270
THE SENATE.

3117
02:18:12,270 --> 02:18:14,206
I ALSO WANT TO MENTION THAT WE

3118
02:18:14,206 --> 02:18:15,807
APPRECIATE SEEING CONGRESS'S

3119
02:18:15,807 --> 02:18:17,776
INTEREST IN CANCER RESEARCH

3120
02:18:17,776 --> 02:18:19,778
ILLUSTRATED HERE WITH IMAGES OF

3121
02:18:19,778 --> 02:18:21,980
OUR COLLEAGUES TESTIFYING OVER

3122
02:18:21,980 --> 02:18:32,324
THE PAST YEAR OR SO.

3123
02:18:51,777 --> 02:18:54,112
>> AND IT'S ENCOURAGING TO
SEE

3124
02:18:54,112 --> 02:19:01,887
THE CONGRESSIONAL INTEREST.

3125
02:19:01,887 --> 02:19:06,224
SO THE TIMING FOR THE FY23

3126
02:19:06,224 --> 02:19:08,093
BUDGET PROCESS IS IN A UNIQUE

3127
02:19:08,093 --> 02:19:09,594
YEAR.

3128
02:19:09,594 --> 02:19:15,333
WE SAW OUR BUDGET ENACTED FAIRLY

3129
02:19:15,333 --> 02:19:18,570
LATE WITH THE PRESIDENT'S BUDGET

3130
02:19:18,570 --> 02:19:19,905
RELEASED ON MARCH 28.

3131
02:19:19,905 --> 02:19:25,177
AND YOU LIKELY HEARD OR READ --

3132
02:19:25,177 --> 02:19:27,446
-- REFERENCE THE

3133
02:19:27,446 --> 02:19:28,313
ADMINISTRATION'S CONTINUED

3134
02:19:28,313 --> 02:19:29,781
COMMITMENT TO BIOMEDICAL

3135
02:19:29,781 --> 02:19:31,183
RESEARCH.

3136
02:19:31,183 --> 02:19:36,822
WE'RE ENCOURAGED TO SEE

3137
02:19:36,822 --> 02:19:47,299
CONGRESS'S COMMITMENT -.

3138
02:19:57,209 --> 02:19:59,044
THE ISSUE AROUND THE BALANCE OF

3139
02:19:59,044 --> 02:20:09,588
FUNDING ACROSS NIH AND ARPA-H --

3140
02:20:09,988 --> 02:20:16,795
IS A TOPIC FOR DISCUSSION.

3141
02:20:16,795 --> 02:20:19,531
SO THE SUBCOMMITTEE PROPOSED AN

3142
02:20:19,531 --> 02:20:27,906
OVER-ALL -- OF $2.5 BILLION.

3143
02:20:27,906 --> 02:20:33,545
AND THE SUBCOMMITTEE PROPOSED AN

3144
02:20:33,545 --> 02:20:35,046
INCREASE --

3145
02:20:35,046 --> 02:20:44,289
[ INDISCERNIBLE ]

3146
02:20:44,289 --> 02:20:55,467
[ OVERLAPPING SPARE SO, THAT ISE

3147
02:21:08,346 --> 02:21:12,551
APPROACH RANGE'S PROCESS STAND.

3148
02:21:12,551 --> 02:21:15,287
* THERE ARE MANY PROPOSALS

3149
02:21:15,287 --> 02:21:18,156
ENDING AND NOT A LOT OF TIME

3150
02:21:18,156 --> 02:21:26,164
LEFT TO REACH AGREEMENTS.

3151
02:21:26,164 --> 02:21:28,733
THERE ARE A FEW PIECES OF

3152
02:21:28,733 --> 02:21:30,068
LEGISLATION THAT ARE CONSIDERED

3153
02:21:30,068 --> 02:21:32,170
MUST PASS AND I'LL TALK BRIEFLY

3154
02:21:32,170 --> 02:21:35,640
ABOUT ONE OF THOSE TODAY.

3155
02:21:35,640 --> 02:21:40,745
AND THERE ARE OTHER PRIORITIES

3156
02:21:40,745 --> 02:21:42,113
THAT ARE POSSIBLE BUT NOT

3157
02:21:42,113 --> 02:21:52,324
GUARANTEED.

3158
02:22:00,465 --> 02:22:02,601
AND THERE ARE SEVERAL BILLS

3159
02:22:02,601 --> 02:22:04,002
INCLUDING ONE THAT CLEARED THE

3160
02:22:04,002 --> 02:22:04,736
HOUSE LAST WEEK.

3161
02:22:04,736 --> 02:22:07,272
WE STARTED WITH THREE PROPOSALS

3162
02:22:07,272 --> 02:22:09,007
AND THAT IS NARROWING DOWN TO

3163
02:22:09,007 --> 02:22:12,877
TWO AS REPRESENTATIVES --

3164
02:22:12,877 --> 02:22:15,347
CHAMPIONS OF THE 21st

3165
02:22:15,347 --> 02:22:20,018
CENTURY CURES ACT -- HAVE REALLY

3166
02:22:20,018 --> 02:22:24,122
[ INDISCERNIBLE ]

3167
02:22:24,122 --> 02:22:24,255
--

3168
02:22:24,255 --> 02:22:26,758
[ INDISCERNIBLE ]

3169
02:22:26,758 --> 02:22:30,829
AND CONGRESSWOMAN ASHLEY'S BILL

3170
02:22:30,829 --> 02:22:35,934
PASSED -- THE BILL AIMS TO

3171
02:22:35,934 --> 02:22:38,603
ESTABLISH ARPA-H -- AND

3172
02:22:38,603 --> 02:22:40,005
ADDITIONAL PROVISIONS ADDRESS

3173
02:22:40,005 --> 02:22:41,906
THE STRUCTURE AND OPERATIONS OF

3174
02:22:41,906 --> 02:22:45,143
THE AGENCY AND THE BILL WAS

3175
02:22:45,143 --> 02:22:46,277
AMENDED SPECIFICALLY TO PROVIDE

3176
02:22:46,277 --> 02:22:49,681
THAT WHILE THE DIRECTOR WOULD BE

3177
02:22:49,681 --> 02:22:50,915
PRESIDENTIALLY APPOINTED THE

3178
02:22:50,915 --> 02:22:58,990
APPOINTMENT WOULD NOT REQUIRE

3179
02:22:58,990 --> 02:23:09,334
SENATE CONFIRMATION.

3180
02:23:14,839 --> 02:23:17,942
THE GEOGRAPHIC LOCATION FOR

3181
02:23:17,942 --> 02:23:18,943
ARPA-H IS STILL TO BE

3182
02:23:18,943 --> 02:23:19,978
DETERMINED.

3183
02:23:19,978 --> 02:23:22,080
BOTH THE HOUSE AND THE SENATE A

3184
02:23:22,080 --> 02:23:24,282
YOU AUTHORIZING BILLS SPEAK FEW

3185
02:23:24,282 --> 02:23:27,185
THAT IT COULD NOT BE LOCATED ON

3186
02:23:27,185 --> 02:23:28,687
ANY NIH CAMPUS.

3187
02:23:28,687 --> 02:23:30,455
HOWEVER WE DON'T KNOW WHERE IT

3188
02:23:30,455 --> 02:23:33,925
WILL HAND AND SEVERAL STATE

3189
02:23:33,925 --> 02:23:36,227
DELEGATIONS ARE WRITING AND

3190
02:23:36,227 --> 02:23:39,631
ADVOCATING FOR THEIR STATES AS

3191
02:23:39,631 --> 02:23:47,172
POTENTIAL HOMES TO ARPA-H.

3192
02:23:47,172 --> 02:23:49,240
I ALSO WANT TO BRIEFLY MENTION

3193
02:23:49,240 --> 02:23:59,718
THE FDA USER FEE PROPOSALS.

3194
02:24:03,354 --> 02:24:06,424
TWO AREAS THAT I THOUGHT MIGHT

3195
02:24:06,424 --> 02:24:07,659
BE OF PARTICULAR INTEREST.

3196
02:24:07,659 --> 02:24:11,129
THE HOUSE HAS PASSED ITS

3197
02:24:11,129 --> 02:24:12,597
VERSION.

3198
02:24:12,597 --> 02:24:14,265
WHICH INCLUDES PROVISIONS

3199
02:24:14,265 --> 02:24:21,139
DIRECTOR OFFED THE FDA.

3200
02:24:21,139 --> 02:24:23,274
AND IT ALSO INCLUDES PROVISIONS

3201
02:24:23,274 --> 02:24:26,444
FROM THE -- GIVE KIDS A CHANCE

3202
02:24:26,444 --> 02:24:34,052
ACT.

3203
02:24:34,052 --> 02:24:35,520
AND THERE IS MORE INFORMATION

3204
02:24:35,520 --> 02:24:38,523
ABOUT EACH OF THESE ADDITIONAL

3205
02:24:38,523 --> 02:24:40,058
PROPOSALS INCLUDED IN YOUR

3206
02:24:40,058 --> 02:24:41,025
WRITTEN UPDATE.

3207
02:24:41,025 --> 02:24:42,927
THE SENATE BILL IS STILL PENDING

3208
02:24:42,927 --> 02:24:52,771
A FINAL VOTE.

3209
02:24:52,771 --> 02:24:55,340
THE SENATE BILL DOES NOT INCLUDE

3210
02:24:55,340 --> 02:24:59,210
THE SAME CLINICAL TRIAL

3211
02:24:59,210 --> 02:24:59,878
PROVISIONS.

3212
02:24:59,878 --> 02:25:01,546
HOWEVER SENATOR MURRAY DID

3213
02:25:01,546 --> 02:25:03,081
MENTION DURING COMMITTEE MARKUP

3214
02:25:03,081 --> 02:25:06,618
THAT SHE HAD WORKED WITH SENATOR

3215
02:25:06,618 --> 02:25:08,686
RUBIO AND SENATOR BENNETT WHEN

3216
02:25:08,686 --> 02:25:10,922
THE BILL COMES UP FOR A FLOOR

3217
02:25:10,922 --> 02:25:11,489
VOTE.

3218
02:25:11,489 --> 02:25:13,491
THESE ARE A FEW OF THE ISSUES

3219
02:25:13,491 --> 02:25:16,561
THAT NEED TO BE RESOLVED.

3220
02:25:16,561 --> 02:25:19,697
BEFORE THE HOUSE AND THE SENATE

3221
02:25:19,697 --> 02:25:21,966
PASS A FINAL AUTHORIZATION FOR

3222
02:25:21,966 --> 02:25:28,006
THE PRESIDENT'S SIGNATURE.

3223
02:25:28,006 --> 02:25:31,776
SO I HAVE WORK TO DO.

3224
02:25:31,776 --> 02:25:34,679
SWITCHING GEARS I ALSO WANTED TO

3225
02:25:34,679 --> 02:25:36,414
HIGHLIGHT TWO RECENT

3226
02:25:36,414 --> 02:25:39,918
CONGRESSIONAL BRIEFING.

3227
02:25:39,918 --> 02:25:43,988
LAST MONTH DR. -- CHIEF OF NCI

3228
02:25:43,988 --> 02:25:46,758
PEDIATRIC AND ONCOLOGY BRANCH

3229
02:25:46,758 --> 02:25:49,394
SPOKE AT A HYBRID CONGRESSIONAL

3230
02:25:49,394 --> 02:25:53,097
BRIEFING TO HONOR -- AWARENESS

3231
02:25:53,097 --> 02:25:58,436
DAY.

3232
02:25:58,436 --> 02:26:07,712
ADDITIONALLY DR. AMY LeBLANC

3233
02:26:07,712 --> 02:26:11,850
-- SPOKE ABOUT THIS WORK.

3234
02:26:11,850 --> 02:26:14,252
SO THIS TWEET IS NOT FROM THE

3235
02:26:14,252 --> 02:26:16,855
BRIEFING BUT I COULD NOT RESIST

3236
02:26:16,855 --> 02:26:18,423
FROM INCLUDING IT.

3237
02:26:18,423 --> 02:26:21,626
YOU CAN FOLLOW THE COMPARATIVE

3238
02:26:21,626 --> 02:26:25,663
ONCOLOGY PROGRAM.

3239
02:26:25,663 --> 02:26:32,403
[ INDISCERNIBLE ]

3240
02:26:32,403 --> 02:26:33,838
PLEASE DON'T HESITATE TO REACH

3241
02:26:33,838 --> 02:26:41,479
OUT TO ME OT -- ME AND OUR TEAM.

3242
02:26:41,479 --> 02:26:44,716
I OFTEN CLOSE WITH A SNAPSHOT OF

3243
02:26:44,716 --> 02:26:46,851
THE CONGRESSIONAL CALENDERS A

3244
02:26:46,851 --> 02:26:48,820
REMINDER OF WHERE WE ARE IN THE

3245
02:26:48,820 --> 02:26:49,487
PROCESS.

3246
02:26:49,487 --> 02:26:51,122
SO HERE WE ARE IN JUNE HEADING

3247
02:26:51,122 --> 02:27:01,566
INTO THE JULY 4th RECESS.

3248
02:27:04,702 --> 02:27:07,071
AS I MENTIONED IT'S ALSO A

3249
02:27:07,071 --> 02:27:08,973
MID-TERM ELECTION YEAR AND IF WE

3250
02:27:08,973 --> 02:27:10,642
HAD MORE TIME I WOULD SAY MORE

3251
02:27:10,642 --> 02:27:13,111
ABOUT WHAT THAT COULD MEAN.

3252
02:27:13,111 --> 02:27:14,746
BUT FOR THE PURPOSE OF THE

3253
02:27:14,746 --> 02:27:18,249
CALENDAR IT MEANS THE HOUSE IS

3254
02:27:18,249 --> 02:27:21,986
NOT IN SESSION AT ALL IN AUGUST

3255
02:27:21,986 --> 02:27:29,027
AND SEPTEMBER AND EARLY OCTOBER.

3256
02:27:29,027 --> 02:27:30,261
WE ALSO RECOGNIZE THAT

3257
02:27:30,261 --> 02:27:31,963
CONTINUING RESOLUTIONS ARE A

3258
02:27:31,963 --> 02:27:33,798
COMMON OCCURRENCE PARTICULARLY

3259
02:27:33,798 --> 02:27:35,733
DURING A MID-TERM ELECTION YEAR

3260
02:27:35,733 --> 02:27:39,570
SO WE WILL BE WATCHING CLOSELY.

3261
02:27:39,570 --> 02:27:40,905
I'M SURE THERE ARE TIMELY

3262
02:27:40,905 --> 02:27:41,739
UPDATES.

3263
02:27:41,739 --> 02:27:44,409
THE NEXT MEETING IS SCHEDULED

3264
02:27:44,409 --> 02:27:46,244
FOR SEPTEMBER 28th.

3265
02:27:46,244 --> 02:27:47,779
TWO DAYS BEFORE THE CLOSE OF THE

3266
02:27:47,779 --> 02:27:49,247
FISCAL YEAR.

3267
02:27:49,247 --> 02:27:50,048
THANK YOU.

3268
02:27:50,048 --> 02:27:52,350
AS ALWAYS IF WE HAVE TIME I'M

3269
02:27:52,350 --> 02:27:54,218
HAPPY TO TAKE QUESTIONS.

3270
02:27:54,218 --> 02:27:57,121
OTHERWISE I THINK I'VE SHARED MY

3271
02:27:57,121 --> 02:27:58,189
E-MAIL WITH THE GROUP BEFORE.

3272
02:27:58,189 --> 02:28:00,391
I'M HAPPY TO FOLLOW-UP AS WELL

3273
02:28:00,391 --> 02:28:00,591
WITH.

3274
02:28:00,591 --> 02:28:05,797
THANK YOU.

3275
02:28:05,797 --> 02:28:06,264
>> HOLLY.

3276
02:28:06,264 --> 02:28:07,398
THANK YOU SO MUCH.

3277
02:28:07,398 --> 02:28:09,300
IF WE HAVE ANY QUESTIONS -- WE

3278
02:28:09,300 --> 02:28:12,403
CAN PUT THEM IN THE CHAT AND

3279
02:28:12,403 --> 02:28:14,605
FOLLOW-UP FOR SURE AND WE CAN

3280
02:28:14,605 --> 02:28:16,074
SHARE HOLLY'S INFORMATION IF

3281
02:28:16,074 --> 02:28:17,976
THERE IS ANY ADDITIONAL

3282
02:28:17,976 --> 02:28:18,443
FOLLOW-UPS.

3283
02:28:18,443 --> 02:28:21,145
DUE TO TIME WE'LL MOVE INTO OUR

3284
02:28:21,145 --> 02:28:22,513
NEXT PANEL DISCUSSION.

3285
02:28:22,513 --> 02:28:24,749
AND JUST AS A REMINDER FOR

3286
02:28:24,749 --> 02:28:26,551
EVERYONE HOLLY THANK YOU SO MUCH

3287
02:28:26,551 --> 02:28:29,153
FOR YOUR PRESENTATION.

3288
02:28:29,153 --> 02:28:30,822
>> THANK YOU, OF COURSE.

3289
02:28:30,822 --> 02:28:33,858
>> OUR NEXT PANEL IS
FOCUSED OFF

3290
02:28:33,858 --> 02:28:36,561
RESEARCH ADVOCACY TRAINING.

3291
02:28:36,561 --> 02:28:38,963
REFLECTING ON WHAT IS HAPPENING

3292
02:28:38,963 --> 02:28:40,898
IN THE COMMUNITY.

3293
02:28:40,898 --> 02:28:42,233
WHAT ARE SOME OPPORTUNITIES THAT

3294
02:28:42,233 --> 02:28:45,603
WE'RE SEEING.

3295
02:28:45,603 --> 02:28:47,739
OUTREACH PROGRAMS AND ENGAGEMENT

3296
02:28:47,739 --> 02:28:49,340
PROGRAMS THAT ARE HELPING TO

3297
02:28:49,340 --> 02:28:51,209
SUPPORT RESEARCH ADVOCATES AND

3298
02:28:51,209 --> 02:28:52,744
PROVIDING GUIDANCE AND MAKING

3299
02:28:52,744 --> 02:28:54,946
SURE THAT THE PATIENT'S VOICE IS

3300
02:28:54,946 --> 02:28:57,148
HEARD IN RESEARCH.

3301
02:28:57,148 --> 02:29:08,092
WE'RE PLEASED TO HAVE MS. AR --.

3302
02:29:20,838 --> 02:29:23,107
WE'RE ALSO JOINED BY DR. ROBIN

3303
02:29:23,107 --> 02:29:32,483
VANDER POOL.

3304
02:29:32,483 --> 02:29:35,953
I'M GOING TO TURN THIS OVER TO

3305
02:29:35,953 --> 02:29:37,355
DR. VANDER POOL TO FRAME THIS

3306
02:29:37,355 --> 02:29:39,223
OUT FOR US AND MAKE THE

3307
02:29:39,223 --> 02:29:41,726
CONNECTION WITH NCI AND WHAT NCI

3308
02:29:41,726 --> 02:29:48,132
IS DOING AND THEN DR. KREBILL

3309
02:29:48,132 --> 02:29:48,833
WILL FOLLOW HER

3310
02:29:48,833 --> 02:29:52,603
>> THANK YOU FOR THE
WELCOME AND

3311
02:29:52,603 --> 02:29:53,971
INTRODUCTION ANJEE.

3312
02:29:53,971 --> 02:29:55,640
TALKING ABOUT THE COMMUNITY

3313
02:29:55,640 --> 02:29:58,910
OUTREACH AND ENGAGER MEANT

3314
02:29:58,910 --> 02:29:59,444
OPPORTUNITIES.

3315
02:29:59,444 --> 02:30:01,212
AND HOW THAT SUPPORTS THE

3316
02:30:01,212 --> 02:30:02,447
PROJECT THAT HOPE IS GOING TO

3317
02:30:02,447 --> 02:30:04,148
SPEAK ABOUT IN JUST A FEW

3318
02:30:04,148 --> 02:30:05,416
MINUTES.

3319
02:30:05,416 --> 02:30:08,586
COMMUNITY OUTREACH AND

3320
02:30:08,586 --> 02:30:10,121
ENGAGEMENTS HAS BEEN A

3321
02:30:10,121 --> 02:30:12,523
FUNDAMENTAL PART OF THE PROGRAM.

3322
02:30:12,523 --> 02:30:14,459
SINCE ITS INCEPTION.

3323
02:30:14,459 --> 02:30:18,062
IN THE EARLY 1970s AND IN FACT

3324
02:30:18,062 --> 02:30:19,831
YOU WOULD THINK ABOUT THE

3325
02:30:19,831 --> 02:30:22,366
COMMUNITY OUTREACH AND

3326
02:30:22,366 --> 02:30:23,734
ENGAGEMENT WORK DONE WITH THE

3327
02:30:23,734 --> 02:30:25,937
CANCER PREVENTION AND CONTROL OR

3328
02:30:25,937 --> 02:30:27,605
THE POPULATION SCIENCE PROGRAMS

3329
02:30:27,605 --> 02:30:31,576
AT THE CANCER CENTERS.

3330
02:30:31,576 --> 02:30:33,478
HOWEVER, NCI AND THE OFFICE OF

3331
02:30:33,478 --> 02:30:37,115
CANCER CENTERS DECIDED TO

3332
02:30:37,115 --> 02:30:39,517
FORMALIZE THAT ACTIVITY WITH THE

3333
02:30:39,517 --> 02:30:41,752
REISSUANCE OF THE CANCER CENTER

3334
02:30:41,752 --> 02:30:43,821
SUPPORT GRANT FUNDING

3335
02:30:43,821 --> 02:30:44,989
OPPORTUNITY AND GUIDANCE THAT

3336
02:30:44,989 --> 02:30:48,493
THEY PUT OUT EVERY SO OFTEN.

3337
02:30:48,493 --> 02:30:53,898
SO IN 2016 THEY ACTUALLY

3338
02:30:53,898 --> 02:30:55,166
REQUIRED A COMMUNITY OUTREACH

3339
02:30:55,166 --> 02:30:57,768
AND ENGAGEMENT COMPONENT AND

3340
02:30:57,768 --> 02:31:00,404
NARRATIVE SO A 12 PAGE

3341
02:31:00,404 --> 02:31:01,005
NARRATIVE.

3342
02:31:01,005 --> 02:31:03,040
SCORE DRIVING PIECE OF THEIR

3343
02:31:03,040 --> 02:31:05,009
ACTUAL CANCER CENTER SUPPORT

3344
02:31:05,009 --> 02:31:07,311
GRANTS.

3345
02:31:07,311 --> 02:31:09,180
WHICH BEHIND THAT 12 PAGE

3346
02:31:09,180 --> 02:31:11,182
NARRATIVES IDENTIFYING A

3347
02:31:11,182 --> 02:31:12,416
LEADERSHIP STRUCTURE AND ALL OF

3348
02:31:12,416 --> 02:31:14,318
THE ACTIVITIES AND INITIATIVES

3349
02:31:14,318 --> 02:31:17,155
THAT WOULD GO WITH THE COMMUNITY

3350
02:31:17,155 --> 02:31:18,923
OUTREACH ENGAGEMENT CORE AT A

3351
02:31:18,923 --> 02:31:19,690
CANCER CENTER.

3352
02:31:19,690 --> 02:31:22,426
SO AS THE CANCER CENTERS STARTED

3353
02:31:22,426 --> 02:31:27,698
WORKING ON THIS AS A FORMALIZED

3354
02:31:27,698 --> 02:31:30,268
COMPONENT?

3355
02:31:30,268 --> 02:31:31,969
2019NCI REISSUED THE GUIDANCE

3356
02:31:31,969 --> 02:31:33,905
SAYING WE WANT TO YOU WORK NOT

3357
02:31:33,905 --> 02:31:35,540
ONLY TRADITIONAL OUTREACH TO

3358
02:31:35,540 --> 02:31:38,109
YOUR COMMUNITIES AND YOUR

3359
02:31:38,109 --> 02:31:39,744
DEFINED CATCHMENT AREA THE AREA

3360
02:31:39,744 --> 02:31:41,579
IN WHICH YOU SERVE YOUR

3361
02:31:41,579 --> 02:31:43,214
COMMUNITIES AND YOUR PATIENTS

3362
02:31:43,214 --> 02:31:45,583
BUT WE WANT YOU TO ALSO DO WHAT

3363
02:31:45,583 --> 02:31:47,552
WE MIGHT CALL IN REACH.

3364
02:31:47,552 --> 02:31:49,921
IN THAT YOU NEED TO TAKE THE

3365
02:31:49,921 --> 02:31:51,022
COMMUNITY VOICE AND THE

3366
02:31:51,022 --> 02:31:53,691
COMMUNITY PERSPECTIVE TO YOUR

3367
02:31:53,691 --> 02:31:56,060
BASIC SCIENCE PROGRAMS TO YOUR

3368
02:31:56,060 --> 02:32:01,699
CLINICAL SCIENCE PROGRAMS.

3369
02:32:01,699 --> 02:32:04,335
THAT YOU ALL NEED TO TAKE YOUR

3370
02:32:04,335 --> 02:32:06,537
WORK WITH YOUR BASIC SCIENCE

3371
02:32:06,537 --> 02:32:08,973
YOUR CLINICAL SCIENCE AND

3372
02:32:08,973 --> 02:32:09,774
TRANSLATIONAL RESEARCH PROGRAMS

3373
02:32:09,774 --> 02:32:12,410
AND CONNECT THE COMMUNITY TO

3374
02:32:12,410 --> 02:32:15,179
THOSE GROUPS AND REALLY HONING

3375
02:32:15,179 --> 02:32:19,517
IN ON WHAT WE'VE BEEN CALLING A

3376
02:32:19,517 --> 02:32:20,318
BI-DIRECTIONAL RELATIONSHIP

3377
02:32:20,318 --> 02:32:21,586
WHERE THE COMMUNITY NEEDS HELP

3378
02:32:21,586 --> 02:32:23,654
DRIVE THE RESEARCH OF THE CANCER

3379
02:32:23,654 --> 02:32:27,458
CENTER AND THE RESEARCH IS THEN

3380
02:32:27,458 --> 02:32:28,259
RESPONSIVE TO THE COMMUNITY

3381
02:32:28,259 --> 02:32:29,427
NEEDS.

3382
02:32:29,427 --> 02:32:31,562
AND SO THERE IS ACTUALLY A LINE

3383
02:32:31,562 --> 02:32:34,599
IN THE GUIDANCE FROM NCI THAT

3384
02:32:34,599 --> 02:32:38,102
SAYS AND I'M GOING TO READ THIS

3385
02:32:38,102 --> 02:32:39,203
OUT LOUD THAT THE COON CERTIFY

3386
02:32:39,203 --> 02:32:41,639
CENTERS IN WORKING WITH THEIR

3387
02:32:41,639 --> 02:32:43,641
COMMUNITIES SHOULD CATALYZE

3388
02:32:43,641 --> 02:32:46,944
ACTIVITIES OF SPECIAL RELEVANT

3389
02:32:46,944 --> 02:32:53,651
TO THEIR GU -- GEOGRAPHIC AREASD

3390
02:32:53,651 --> 02:32:55,386
ENGAGEMENT WITH COMMUNITIES AND

3391
02:32:55,386 --> 02:32:57,755
PATIENT ADVOCATES SHOULD INFORM

3392
02:32:57,755 --> 02:32:59,557
AND RESULT IN HIGH IMPACT'

3393
02:32:59,557 --> 02:33:00,124
SCIENCE.

3394
02:33:00,124 --> 02:33:01,826
AND AGAIN THAT IS WHAT YOU'RE

3395
02:33:01,826 --> 02:33:03,828
GOING TO HEAR AN EXAMPLE OF THIS

3396
02:33:03,828 --> 02:33:04,295
AFTERNOON.

3397
02:33:04,295 --> 02:33:06,330
AND I THINK YOU CAN IMAGINE THIS

3398
02:33:06,330 --> 02:33:09,166
WAS NOT EASY FOR OUR CANCER

3399
02:33:09,166 --> 02:33:10,568
CENTERS AND OUR COMMUNITY

3400
02:33:10,568 --> 02:33:12,403
OUTREACH PROGRAMS AND OUR BASIC

3401
02:33:12,403 --> 02:33:14,205
SIGN AT THIS I TESTS AND

3402
02:33:14,205 --> 02:33:16,774
CLINICAL SCIENTISTS TO TALK TO

3403
02:33:16,774 --> 02:33:18,909
EACH OTHER FOR THE FIRST TIME.

3404
02:33:18,909 --> 02:33:21,212
OFTEN WE'RE SPEAKING, WE MAY

3405
02:33:21,212 --> 02:33:23,481
HAVE THE SAME GOALS OF IMPROVING

3406
02:33:23,481 --> 02:33:25,216
THE CANCER EXPERIENCE OR

3407
02:33:25,216 --> 02:33:27,118
IMPROVING TREATMENTS OR

3408
02:33:27,118 --> 02:33:28,953
IDENTIFYING PREVENTIONS AND

3409
02:33:28,953 --> 02:33:30,755
SCREENING TECHNOLOGIES BUT WE'RE

3410
02:33:30,755 --> 02:33:32,923
COMING AT IT FROM DIFFERENT

3411
02:33:32,923 --> 02:33:35,059
ANGELS AND DIFFERENT VOICES.

3412
02:33:35,059 --> 02:33:36,994
SO HOW DO WE GET EVERYBODY ON

3413
02:33:36,994 --> 02:33:38,429
THE SAME PAGE?

3414
02:33:38,429 --> 02:33:41,532
HOW CAN WE GET BASIC SCIENTISTS

3415
02:33:41,532 --> 02:33:43,434
TO UNDERSTAND COMMUNITY CONCEPTS

3416
02:33:43,434 --> 02:33:46,671
AND GET COMMUNITY TO UNDERSTAND

3417
02:33:46,671 --> 02:33:50,107
WHY STUDYING MOUSE MODELS AND

3418
02:33:50,107 --> 02:33:52,443
ZEBRAFISH IS A GOOD IDEA FOR OUR

3419
02:33:52,443 --> 02:33:54,679
CANCER RELATED GOALS.

3420
02:33:54,679 --> 02:33:57,715
TO BUILD CAPACITY IN THE SPACE

3421
02:33:57,715 --> 02:33:59,684
BECAUSE CANCER CENTERS ARE GOOD

3422
02:33:59,684 --> 02:34:02,386
AT THE OUTREACH BUT IT'S THAT IN

3423
02:34:02,386 --> 02:34:06,357
REACH OUR DIVISION PUT OUT

3424
02:34:06,357 --> 02:34:07,358
ADMINISTRATIVE SUPPLEMENT TO

3425
02:34:07,358 --> 02:34:09,427
HELP SUPPORT CANCER CENTERS AND

3426
02:34:09,427 --> 02:34:10,594
THEIR COMMUNITY OUTREACH

3427
02:34:10,594 --> 02:34:12,897
PROGRAMS AND THEIR BASIC SCIENCE

3428
02:34:12,897 --> 02:34:15,199
PROGRAMS TO START WORKING

3429
02:34:15,199 --> 02:34:15,533
TOGETHER

3430
02:34:15,533 --> 02:34:17,535
THEY COULD DESIGN A NEW

3431
02:34:17,535 --> 02:34:19,537
COLLABORATION OR BUILD ON AN

3432
02:34:19,537 --> 02:34:21,339
EXISTING COLLABORATION.

3433
02:34:21,339 --> 02:34:23,874
AND THAT IS WHAT YOU'RE GOING TO

3434
02:34:23,874 --> 02:34:24,942
HEAR ABOUT FROM HOPE.

3435
02:34:24,942 --> 02:34:27,511
AT THE UNIVERSITY OF KANSAS HOW

3436
02:34:27,511 --> 02:34:30,581
THEY WERE ABLE TO LEVERAGE THEIR

3437
02:34:30,581 --> 02:34:33,718
PIVOT PROGRAM TO COMPETE FOR ONE

3438
02:34:33,718 --> 02:34:35,786
OF THESE SUPPLEMENTS.

3439
02:34:35,786 --> 02:34:38,456
TO DEVELOP A TRAINING PROGRAM

3440
02:34:38,456 --> 02:34:39,890
ABOUT COMMUNITY OUTREACH AND

3441
02:34:39,890 --> 02:34:40,324
ENGAGEMENT.

3442
02:34:40,324 --> 02:34:42,893
HOW TO COMMUNICATE WITH PATIENTS

3443
02:34:42,893 --> 02:34:43,661
AND COMMUNITIES.

3444
02:34:43,661 --> 02:34:45,563
AND HOW TO WORK TOGETHER.

3445
02:34:45,563 --> 02:34:46,831
THAT WAS THE TRAINING PROGRAM

3446
02:34:46,831 --> 02:34:48,833
THAT THEY CREATED AND WITH THE

3447
02:34:48,833 --> 02:34:51,402
GOAL OF DEVELOPING AND AMERICAN

3448
02:34:51,402 --> 02:34:52,937
TAKENNING THAT MUTUAL

3449
02:34:52,937 --> 02:34:54,739
RELATIONSHIP WHICH MEANS

3450
02:34:54,739 --> 02:34:56,040
SCIENTISTS AND COMMUNITY

3451
02:34:56,040 --> 02:34:57,875
PATIENTLY RESEARCH PARTERS.

3452
02:34:57,875 --> 02:35:00,211
AND WE'VE BEEN REALLY THRILLED

3453
02:35:00,211 --> 02:35:01,712
WITH THESE ACTIVITIES.

3454
02:35:01,712 --> 02:35:03,748
THE PROJECTS LAUNCHED AT THE END

3455
02:35:03,748 --> 02:35:06,384
OF FISCAL YEAR 20 AND HAVE BEEN

3456
02:35:06,384 --> 02:35:07,118
WRAPPING UP.

3457
02:35:07,118 --> 02:35:09,754
WE HAD ALL OF THE CANCER CENTERS

3458
02:35:09,754 --> 02:35:11,422
DEVELOP CASE STUDIES WHICH I'LL

3459
02:35:11,422 --> 02:35:13,124
PUT IN THE CHAT FOR YOU TO LOOK

3460
02:35:13,124 --> 02:35:13,691
OVER.

3461
02:35:13,691 --> 02:35:15,626
SO THAT WE CAN SHARE BEST

3462
02:35:15,626 --> 02:35:18,896
PRACTICES INSTEAD OF EVERYBODY

3463
02:35:18,896 --> 02:35:21,132
REINVENTING THE WHEEL.

3464
02:35:21,132 --> 02:35:22,500
WE'RE THRILLED WITH THE WORK

3465
02:35:22,500 --> 02:35:24,902
THAT HAS HAPPENED IN THE SPACE.

3466
02:35:24,902 --> 02:35:27,405
I'M NOT GOING TO STEAL ANY OF

3467
02:35:27,405 --> 02:35:28,839
HOPE'S THUNDER.

3468
02:35:28,839 --> 02:35:32,042
BUT I WANT TO READ YOU ONE QUOTE

3469
02:35:32,042 --> 02:35:35,479
-- AND THIS IS FROM ONE OF THEIR

3470
02:35:35,479 --> 02:35:36,580
SCIENTISTS.

3471
02:35:36,580 --> 02:35:38,682
DESPITE THE TIME I'VE BEEN

3472
02:35:38,682 --> 02:35:41,285
RESEARCHING CANCER I HAVE NEVER

3473
02:35:41,285 --> 02:35:43,587
MET ANYONE WITH THE DISEASE TYPE

3474
02:35:43,587 --> 02:35:45,489
I WAS INVESTIGATING.

3475
02:35:45,489 --> 02:35:47,925
THE SUPPLEMENT PROGRAM PROVIDING

3476
02:35:47,925 --> 02:35:50,494
ME THE OPPORTUNITY TO MEET AN

3477
02:35:50,494 --> 02:35:51,896
ACTUAL PERSON LIVING WITH THE

3478
02:35:51,896 --> 02:35:53,731
SPECIFIC TYPE OF CANCER I WAS

3479
02:35:53,731 --> 02:35:57,902
RESEARCHING AS WELL AS AN ENTIRE

3480
02:35:57,902 --> 02:35:59,170
ADVOCACY ORGANIZATION.

3481
02:35:59,170 --> 02:36:02,039
AND THAT IS REALLY ONE SPEAKS

3482
02:36:02,039 --> 02:36:04,108
THAT WE HAVE A LOT OF WORK TO DO

3483
02:36:04,108 --> 02:36:06,744
BUT ALSO SPEAKS TO THE

3484
02:36:06,744 --> 02:36:07,745
OPPORTUNITIES THAT EVEN SMALL

3485
02:36:07,745 --> 02:36:09,914
AMOUNTS OF MONEY AND CAPACITY

3486
02:36:09,914 --> 02:36:12,516
BUILDING CAN DO AT THESE CANCER

3487
02:36:12,516 --> 02:36:14,718
CENTERS IN CONNECTING PATIENTLY

3488
02:36:14,718 --> 02:36:16,153
ADVOCATES AND THE SCIENCE

3489
02:36:16,153 --> 02:36:17,655
TOGETHER TO MAKE IT MORE

3490
02:36:17,655 --> 02:36:19,924
RELEVANT FOR OUR PATIENTS AND

3491
02:36:19,924 --> 02:36:22,226
CAREGIVERS AND OUR ENTIRE CANCER

3492
02:36:22,226 --> 02:36:22,693
COMMUNITY.

3493
02:36:22,693 --> 02:36:25,062
WITH THAT I WOULD BE HAPPY TO

3494
02:36:25,062 --> 02:36:26,530
ANSWER QUESTIONS AFTER HOPE'S

3495
02:36:26,530 --> 02:36:36,774
PRESENTATION.

3496
02:36:40,778 --> 02:36:42,112
>> THANK YOU, ROBIN.

3497
02:36:42,112 --> 02:36:44,315
I THINK MY SLIDES WILL BE PULLED

3498
02:36:44,315 --> 02:36:45,749
UP IN JUST A MINUTE.

3499
02:36:45,749 --> 02:36:50,254
I WANT TO THANK ROBIN FORGIVING

3500
02:36:50,254 --> 02:36:52,623
THE INTRODUCTION AS WELL AS

3501
02:36:52,623 --> 02:36:56,227
ANJEE AND DR. LOWY FOR INVITING

3502
02:36:56,227 --> 02:36:56,694
US.

3503
02:36:56,694 --> 02:36:58,996
I REALLY APPRECIATE LISTENING TO

3504
02:36:58,996 --> 02:37:00,130
YOUR CONVERSATIONS AND QUESTIONS

3505
02:37:00,130 --> 02:37:05,803
TO THE RESEARCHERS AND TO

3506
02:37:05,803 --> 02:37:08,572
DR. LOWY.

3507
02:37:08,572 --> 02:37:10,674
I'M GOING TO SPEED UP A LITTLE

3508
02:37:10,674 --> 02:37:12,877
BIT A PART OF MY PRESENTATION IN

3509
02:37:12,877 --> 02:37:23,387
ORDER TO GET US BACK ON TIME.

3510
02:37:28,292 --> 02:37:30,995
THE WORK IS THE WORK OF THE

3511
02:37:30,995 --> 02:37:32,062
SURVIVORS AND THE COMMUNITY

3512
02:37:32,062 --> 02:37:34,164
MEMBERS AND THE FACULTY AND

3513
02:37:34,164 --> 02:37:38,702
STAFF.

3514
02:37:38,702 --> 02:37:41,972
IN 2016 WE CAME TO THE OFFICE OF

3515
02:37:41,972 --> 02:37:44,241
ADVOCACY AT NCI JUST TO SAY WHAT

3516
02:37:44,241 --> 02:37:44,975
IS GOING ON?

3517
02:37:44,975 --> 02:37:47,745
IT WAS A VIRTUAL PHONE CALL.

3518
02:37:47,745 --> 02:37:55,419
TO SEE WHAT WAS GOING ON.

3519
02:37:55,419 --> 02:37:58,322
AND I WILL SHARE A BRIEF

3520
02:37:58,322 --> 02:38:02,927
OVERVIEW.

3521
02:38:02,927 --> 02:38:04,562
FASTEN YOUR SEAT BELTS BECAUSE

3522
02:38:04,562 --> 02:38:07,164
I'LL TALK FAST.

3523
02:38:07,164 --> 02:38:13,103
I TALK WHY WE ENINVOLVE PATIENT

3524
02:38:13,103 --> 02:38:15,739
ADVOCATES THE AND GIVE AN

3525
02:38:15,739 --> 02:38:19,944
EXAMPLE -- * AND SHARE LESSONS

3526
02:38:19,944 --> 02:38:21,378
LEARNED AND OUTCOMES.

3527
02:38:21,378 --> 02:38:22,913
THE UNIVERSITY OF KANSAS IS

3528
02:38:22,913 --> 02:38:25,249
LOCATED ON THE STATE LINE.

3529
02:38:25,249 --> 02:38:27,451
THE STATE OF KANSAS AS WELL AS

3530
02:38:27,451 --> 02:38:31,689
18 COUNTIES IN MISSOURI.

3531
02:38:31,689 --> 02:38:32,890
4.5 MILLION PEOPLE.

3532
02:38:32,890 --> 02:38:35,125
THE BLUE AREAS REPRESENT RURAL

3533
02:38:35,125 --> 02:38:36,760
AREAS AND SOME OF THE COUNTIES

3534
02:38:36,760 --> 02:38:38,996
HAVE LESS THAN SIX PEOPLE PER

3535
02:38:38,996 --> 02:38:41,298
SQUARE MILE.

3536
02:38:41,298 --> 02:38:43,901
AND WE HAD TO THINK HOW ARE WE

3537
02:38:43,901 --> 02:38:45,636
GOING TO DO COMMUNITY OUTREACH

3538
02:38:45,636 --> 02:38:48,505
AND ENGAGEMENT WITH SUCH A LARGE

3539
02:38:48,505 --> 02:38:50,240
LAND MASS.

3540
02:38:50,240 --> 02:38:54,378
TWICE THE SIZE OF MANY STATES.

3541
02:38:54,378 --> 02:38:56,981
SO WE NEEDED TO FIRST IDENTIFY

3542
02:38:56,981 --> 02:38:58,749
AND MONITOR AND UNDERSTAND THE

3543
02:38:58,749 --> 02:38:59,283
DATA.

3544
02:38:59,283 --> 02:39:02,620
WHAT IS HAPPENING IN OUR CANCER

3545
02:39:02,620 --> 02:39:12,896
COMMUNITY IN OUR CATCHMENT AREA.

3546
02:39:12,896 --> 02:39:23,374
WE KNEW THAT WAS NOT ENOUGH.

3547
02:39:26,076 --> 02:39:27,578
WHAT ARE THE STRENGTHS OF THE

3548
02:39:27,578 --> 02:39:31,882
COMMUNITY.

3549
02:39:31,882 --> 02:39:34,551
HOW DO WE STIMULATE THAT

3550
02:39:34,551 --> 02:39:35,319
INFORMATION INTO IMPORTANT

3551
02:39:35,319 --> 02:39:36,654
RESEARCH.

3552
02:39:36,654 --> 02:39:38,889
THAT IS WHERE PIVOT COMES IN

3553
02:39:38,889 --> 02:39:39,390
PLAY.

3554
02:39:39,390 --> 02:39:42,860
WE NEED TO HEAR FROM THE

3555
02:39:42,860 --> 02:39:44,862
ADVOCATES AND THEN HOW DO WE GET

3556
02:39:44,862 --> 02:39:47,531
THE SCIENCE INTO MAKING AND

3557
02:39:47,531 --> 02:39:48,666
DOING GOOD.

3558
02:39:48,666 --> 02:39:51,502
DRIVE AND DISSEMINATE AND

3559
02:39:51,502 --> 02:39:55,472
IMPLEMENT ACTIVITIES AND WE DO

3560
02:39:55,472 --> 02:39:57,541
THAT THROUGH THE ALLIANCE.

3561
02:39:57,541 --> 02:39:59,810
WE EXTEND CLINICAL TRIALS

3562
02:39:59,810 --> 02:40:01,879
INCLUDING AND CORE TRIALS INTO

3563
02:40:01,879 --> 02:40:03,914
COMMUNITY CANCER CENTERS ACROSS

3564
02:40:03,914 --> 02:40:05,749
THE STATE OF KANSAS AS WELL AS

3565
02:40:05,749 --> 02:40:07,751
PROVIDE OUTREACH AND PARTNER ON

3566
02:40:07,751 --> 02:40:10,854
EVIDENCE BASED INTERVENTION --

3567
02:40:10,854 --> 02:40:14,825
AND ALSO TRAIN PROFESSIONALS

3568
02:40:14,825 --> 02:40:16,627
ACROSS THE STATE.

3569
02:40:16,627 --> 02:40:19,897
NEXT SLIDE PLEASE.

3570
02:40:19,897 --> 02:40:22,232
SO WE HAD A BOARD AS I MENTIONED

3571
02:40:22,232 --> 02:40:25,936
BEFORE AND THEY ARE 18

3572
02:40:25,936 --> 02:40:27,104
INDIVIDUALS THAT MEET FOUR TIMES

3573
02:40:27,104 --> 02:40:35,112
A YEAR -- WHY DO WE HAVE THIS

3574
02:40:35,112 --> 02:40:36,447
BOARD?

3575
02:40:36,447 --> 02:40:37,881
DO WE NEED TO DO SOMETHING

3576
02:40:37,881 --> 02:40:46,523
DIFFERENT.

3577
02:40:46,523 --> 02:40:48,892
PARTNERED WITH CHERYL JOURN

3578
02:40:48,892 --> 02:40:51,929
BEGAN -- PROBABLY MANY OF YOU

3579
02:40:51,929 --> 02:40:52,563
KNOW HER.

3580
02:40:52,563 --> 02:40:55,032
THEY CAME TO OUR DIRECTOR AND

3581
02:40:55,032 --> 02:40:58,635
SAID HEY WE THINK KU NEEDS ITS

3582
02:40:58,635 --> 02:41:00,871
OWN PATIENT RESEARCH ADVOCACY

3583
02:41:00,871 --> 02:41:04,274
PROGRAM AND THEY PULLED THEM

3584
02:41:04,274 --> 02:41:05,676
TOGETHER AND WE WERE ALL

3585
02:41:05,676 --> 02:41:06,110
ON-BOARD.

3586
02:41:06,110 --> 02:41:09,513
THIS IS A GREAT IDEA.

3587
02:41:09,513 --> 02:41:14,818
AVENUE DR. JENSON INVESTED HIS

3588
02:41:14,818 --> 02:41:17,721
TIME AND TREASURES SO WE COULD

3589
02:41:17,721 --> 02:41:21,425
DEVELOP THIS PROGRAM.

3590
02:41:21,425 --> 02:41:22,760
SO THE COMMUNITY ADVISORY BOARD

3591
02:41:22,760 --> 02:41:24,428
IS DIFFERENT AND WE HAD TO THINK

3592
02:41:24,428 --> 02:41:26,764
ABOUT IT.

3593
02:41:26,764 --> 02:41:27,898
WHAT IS THE ROLE?

3594
02:41:27,898 --> 02:41:31,135
THE COMMUNITY ADVISORY BOARD IS

3595
02:41:31,135 --> 02:41:37,474
AROUND OVER ARCHING -- WHILE OUR

3596
02:41:37,474 --> 02:41:41,345
PATIENT PARTNERS SPEND TIME ON

3597
02:41:41,345 --> 02:41:43,514
THE RESEARCH PROCESS AND

3598
02:41:43,514 --> 02:41:45,249
PARTICIPATING IN GRANT REVIEWS

3599
02:41:45,249 --> 02:41:47,217
AND PARTICIPATING IN THE

3600
02:41:47,217 --> 02:41:51,188
DEVELOPMENT OF PROTOCOLS -- HELP

3601
02:41:51,188 --> 02:41:55,159
WITH REPORTING THE RESULTS.

3602
02:41:55,159 --> 02:41:57,694
AND WE WANT TO BE CLEAR THAT FOR

3603
02:41:57,694 --> 02:41:59,963
US FOR KU CANCER CENTER WE'RE

3604
02:41:59,963 --> 02:42:02,699
TALKING ABOUT PATIENT RESEARCH

3605
02:42:02,699 --> 02:42:03,433
ADVOCACY.

3606
02:42:03,433 --> 02:42:05,269
WE'RE NOT TALKING ABOUT THE

3607
02:42:05,269 --> 02:42:08,038
OTHER PARTS OF ADVOCACY THAT ARE

3608
02:42:08,038 --> 02:42:11,441
IMPORTANT AND WE'LL HAVE TO

3609
02:42:11,441 --> 02:42:15,712
CONTINUALLY ENGAGE WITH -- AND

3610
02:42:15,712 --> 02:42:18,115
FOR THIS PART FOR PIVOT WE'RE

3611
02:42:18,115 --> 02:42:25,489
TRYING TO MAKE SCIENCE BETTER.

3612
02:42:25,489 --> 02:42:28,559
AND WE DECIDED THAT OUR RESEARCH

3613
02:42:28,559 --> 02:42:34,565
ADVOCATES NEEDED TO BE -- --

3614
02:42:34,565 --> 02:42:38,502
SURVIVORS OR CO-SURVIVORS.

3615
02:42:38,502 --> 02:42:41,104
AND THEY NEED TO BE LIKE YOU

3616
02:42:41,104 --> 02:42:42,806
COMMITTED TO REPRESENTING THE

3617
02:42:42,806 --> 02:42:44,908
COLLECTIVE PATIENT EXPERIENCE.

3618
02:42:44,908 --> 02:42:46,410
THEY NEEDED TO BE TIED TO

3619
02:42:46,410 --> 02:42:48,178
THINKING ABOUT HOW'S SCIENCE

3620
02:42:48,178 --> 02:42:51,181
COULD CHANGE IF THEY SHARED THAT

3621
02:42:51,181 --> 02:42:53,917
COLLECTIVE EXPERIENCE SO THEY

3622
02:42:53,917 --> 02:42:55,752
NEEDED TO MAINTAIN THEIR

3623
02:42:55,752 --> 02:42:56,620
RELATIONSHIPS WITH OTHER PEOPLE

3624
02:42:56,620 --> 02:43:00,591
WHO HAVE EXPERIENCED CANCER.

3625
02:43:00,591 --> 02:43:05,696
SO WHY DOES KU CANCER CENTER

3626
02:43:05,696 --> 02:43:09,399
WANT TO DO THIS?

3627
02:43:09,399 --> 02:43:11,969
WE THINK IT ENSURES PATIENT

3628
02:43:11,969 --> 02:43:13,237
FOCUS AND RELEVANCE.

3629
02:43:13,237 --> 02:43:16,006
ADD A HUMAN FACE.

3630
02:43:16,006 --> 02:43:19,476
PROVIDE REAL LIFE AND DIVERSE

3631
02:43:19,476 --> 02:43:20,878
EXPERTISE.

3632
02:43:20,878 --> 02:43:24,348
AND SPUR INNOVATION BASED ON THE

3633
02:43:24,348 --> 02:43:26,183
EXPERTISE.

3634
02:43:26,183 --> 02:43:31,054
AND THIS IS WHAT THE ATTRIBUTES

3635
02:43:31,054 --> 02:43:34,291
OF A GREAT ADVOCATE -- I TOLD

3636
02:43:34,291 --> 02:43:37,461
YOU HAVE -- TO FASTEN YOUR SAME

3637
02:43:37,461 --> 02:43:39,529
BELTS.

3638
02:43:39,529 --> 02:43:41,899
-- SEATBELTS.

3639
02:43:41,899 --> 02:43:49,139
* WE WANTED TO WALK THE WORK.

3640
02:43:49,139 --> 02:43:50,641
 -- WE HAVE WANTED TO WALK THE

3641
02:43:50,641 --> 02:43:51,775
WALK.

3642
02:43:51,775 --> 02:43:53,777
WE WANTED TO LISTEN.

3643
02:43:53,777 --> 02:43:59,082
WE LAUNCHED OUR FIRST MEETING --

3644
02:43:59,082 --> 02:44:00,317
WE WERE HYBRID FROM THE

3645
02:44:00,317 --> 02:44:03,921
BEGINNING AND THAT WAS ZOOM BY

3646
02:44:03,921 --> 02:44:06,189
THE WAY AND BEFORE COVID.

3647
02:44:06,189 --> 02:44:08,792
AND WE MADE SURE THAT THE SEATS

3648
02:44:08,792 --> 02:44:10,494
AT THE TABLE WERE GOING TO BE

3649
02:44:10,494 --> 02:44:12,996
AVAILABLE TO A DIVERSE

3650
02:44:12,996 --> 02:44:13,997
EXPERIENCE.

3651
02:44:13,997 --> 02:44:17,167
SO BY AGE, RACE, ETHNICITY,

3652
02:44:17,167 --> 02:44:18,936
CANCER EXPERIENCE.

3653
02:44:18,936 --> 02:44:21,872
CANCER DIAGNOSIS.

3654
02:44:21,872 --> 02:44:23,607
REALLY WANTED TO MAKE SURE THAT

3655
02:44:23,607 --> 02:44:27,878
WE THOUGHT ABOUT INSURANCE, NO

3656
02:44:27,878 --> 02:44:29,179
INSURANCE.

3657
02:44:29,179 --> 02:44:29,446
ECONOMICS.

3658
02:44:29,446 --> 02:44:30,981
SO WE HAD TO LEAVE OUR SEATS

3659
02:44:30,981 --> 02:44:33,383
OPEN AND THERE WERE TIMES WHEN I

3660
02:44:33,383 --> 02:44:35,185
WOULD HAVE PEOPLE THAT I LOVED

3661
02:44:35,185 --> 02:44:36,320
AND CARED ABOUT SAYING I HAVE

3662
02:44:36,320 --> 02:44:37,988
THIS WOMAN WHO WOULD BE GREAT

3663
02:44:37,988 --> 02:44:41,224
FOR YOUR BOARD -- AND WE HAD A

3664
02:44:41,224 --> 02:44:43,493
LOT OF WHITE WOMEN WITH BREAST

3665
02:44:43,493 --> 02:44:45,295
CANCER THAT WAND TO

3666
02:44:45,295 --> 02:44:46,029
PARTICIPATED.

3667
02:44:46,029 --> 02:44:51,168
WE WANT TO INTENTIONALLY LEAVE

3668
02:44:51,168 --> 02:45:01,411
THE SEAT OPEN.

3669
02:45:01,845 --> 02:45:03,847
>> SO IT WAS PATIENT
DRIVEN.

3670
02:45:03,847 --> 02:45:06,283
THE ADVOCATES ACTUALLY CREATED

3671
02:45:06,283 --> 02:45:08,752
THE VISION.

3672
02:45:08,752 --> 02:45:13,724
WE LAUNCHED INTO A 12 PATIENT

3673
02:45:13,724 --> 02:45:24,101
LELEADER TEAM.

3674
02:45:30,807 --> 02:45:32,843
THAT IS FROM A OUR FIRST

3675
02:45:32,843 --> 02:45:35,212
TRAINING WHERE WE HAD ABOUT 40

3676
02:45:35,212 --> 02:45:36,947
ADVOCATES AND THEY WERE NOT

3677
02:45:36,947 --> 02:45:37,714
ADVOCATES YET.

3678
02:45:37,714 --> 02:45:40,017
THEY WERE SAYING MAYBE I WANT TO

3679
02:45:40,017 --> 02:45:40,450
DO THIS.

3680
02:45:40,450 --> 02:45:41,718
I'M NOT SURE.

3681
02:45:41,718 --> 02:45:46,490
AND WE ASKED EVERYONE HOW WOULD

3682
02:45:46,490 --> 02:45:47,758
THEY DESCRIBE RESEARCH?

3683
02:45:47,758 --> 02:45:51,228
AND THE WORDS THAT CAME OUT THE

3684
02:45:51,228 --> 02:45:53,497
BIGGER WORDS CAME OUT MORE

3685
02:45:53,497 --> 02:45:53,997
FREQUENTLY.

3686
02:45:53,997 --> 02:45:55,532
CONVENIENT FOR ME TO HAVE MY

3687
02:45:55,532 --> 02:45:58,268
NAME ON THE SLIDE.

3688
02:45:58,268 --> 02:46:00,137
HOPE, LIFE, FAMILY.

3689
02:46:00,137 --> 02:46:01,671
TIME.

3690
02:46:01,671 --> 02:46:04,107
AND SO I THINK THEY HAD SOME

3691
02:46:04,107 --> 02:46:05,375
REAL LIFE EXPERIENCES AND YOU

3692
02:46:05,375 --> 02:46:07,277
CAN SEE THE PICTURES OF A

3693
02:46:07,277 --> 02:46:09,312
VARIETY OF ADVOCATES THAT

3694
02:46:09,312 --> 02:46:10,447
PARTICIPATE.

3695
02:46:10,447 --> 02:46:12,549
IF YOU LOOK CLOSELY YOU'LL SEE

3696
02:46:12,549 --> 02:46:15,052
ON THE T-SHIRT IT SAYS MY VOICE

3697
02:46:15,052 --> 02:46:17,087
IS MY SUPER POWER AND THAT IS

3698
02:46:17,087 --> 02:46:20,924
WHAT WE WANTED TO CREATE THROUGH

3699
02:46:20,924 --> 02:46:21,925
PATIENT RESEARCH AND

3700
02:46:21,925 --> 02:46:22,559
PARTNERSHIPS.

3701
02:46:22,559 --> 02:46:25,162
AND THE T-SHIRT WAS CREATED BY

3702
02:46:25,162 --> 02:46:27,397
THE COMMUNICATION TEAM THAT IS

3703
02:46:27,397 --> 02:46:30,500
RUN BY PATIENTLY ADVOCATES.

3704
02:46:30,500 --> 02:46:32,702
SO NOW WE HAVE OVER 130 MEMBERS.

3705
02:46:32,702 --> 02:46:34,337
HARD TO BELIEF.

3706
02:46:34,337 --> 02:46:37,574
AND IF YOU CAN SEE THEY HAVE

3707
02:46:37,574 --> 02:46:39,676
NUMBERS IN THEM.

3708
02:46:39,676 --> 02:46:42,979
WE'RE STILL WORKING TO GET

3709
02:46:42,979 --> 02:46:45,282
FURTHER OUT WEST.

3710
02:46:45,282 --> 02:46:47,184
EASIER TO RECRUIT PEOPLE THAT

3711
02:46:47,184 --> 02:46:48,485
ARE CLOSE US TO.

3712
02:46:48,485 --> 02:46:50,620
BUT WE'RE STILL RECRUITING.

3713
02:46:50,620 --> 02:46:53,223
VARIED EXPERIENCES OF CANCER

3714
02:46:53,223 --> 02:46:56,326
TYPES, AGE, GENDER.

3715
02:46:56,326 --> 02:47:00,597
WE'VE HAD PEOPLE JOIN -- THAT

3716
02:47:00,597 --> 02:47:03,800
ARE OUTSIDE OF OUR CATCH MAN

3717
02:47:03,800 --> 02:47:05,035
AREA.

3718
02:47:05,035 --> 02:47:07,537
WE LIMIT OUR PARTNERSHIPS TO

3719
02:47:07,537 --> 02:47:10,340
THOSE WITHIN OUR CATCHMENT AREA.

3720
02:47:10,340 --> 02:47:11,875
THIS GIVES YOU AN IDEA.

3721
02:47:11,875 --> 02:47:13,877
WE'RE HOSTING ANOTHER TRAINING

3722
02:47:13,877 --> 02:47:24,154
AGAIN IN PERSON.

3723
02:47:24,421 --> 02:47:27,457
SO THE PATIENT ADVOCATE TRAINING

3724
02:47:27,457 --> 02:47:29,993
HAS BEEN CREATED BY OUR TASK

3725
02:47:29,993 --> 02:47:30,560
FORCE.

3726
02:47:30,560 --> 02:47:33,196
IT IS LED BYE-BYE THE PATIENT

3727
02:47:33,196 --> 02:47:34,498
RESEARCH ADVOCATES.

3728
02:47:34,498 --> 02:47:36,700
VOTED ON BY THE PATIENT RESEARCH

3729
02:47:36,700 --> 02:47:37,067
ADVOCATES.

3730
02:47:37,067 --> 02:47:40,637
I DON'T HAVE A VOTE WHICH I

3731
02:47:40,637 --> 02:47:41,938
THINK IS RIGHT BECAUSE THIS

3732
02:47:41,938 --> 02:47:43,273
NEEDS TO BE PATIENT DRIVEN.

3733
02:47:43,273 --> 02:47:45,408
THE EDUCATION COMMITTEE HAS

3734
02:47:45,408 --> 02:47:46,610
PULLED TOGETHER DIVERSE

3735
02:47:46,610 --> 02:47:48,645
PRESENTATIONS THAT ARE AVAILABLE

3736
02:47:48,645 --> 02:47:49,946
BY ZOOM.

3737
02:47:49,946 --> 02:47:51,414
IN PERSON, HYBRID.

3738
02:47:51,414 --> 02:47:55,519
AND THE TOPICS INCLUDE CANCER

3739
02:47:55,519 --> 02:47:56,553
RESEARCH 101.

3740
02:47:56,553 --> 02:48:00,490
BUT ALSO HOW TO CREATE A

3741
02:48:00,490 --> 02:48:01,057
BIOSKETCH.

3742
02:48:01,057 --> 02:48:03,994
IT'S NOT SET UP FOR ADVOCATE TO

3743
02:48:03,994 --> 02:48:04,761
SUBMIT.

3744
02:48:04,761 --> 02:48:06,897
BUT IT'S NEEDED IF THEY ARE ON A

3745
02:48:06,897 --> 02:48:08,131
RESEARCH PROPOSAL.

3746
02:48:08,131 --> 02:48:09,666
THEY WANTED TO UNDERSTAND ABOUT

3747
02:48:09,666 --> 02:48:11,568
THE TRANSLATIONAL RESEARCH TIME

3748
02:48:11,568 --> 02:48:13,703
LINE AND AS YOU KNOW THAT IS WAY

3749
02:48:13,703 --> 02:48:15,338
TOO LONG.

3750
02:48:15,338 --> 02:48:17,741
SO THEY WERE DISAPPOINTED IN

3751
02:48:17,741 --> 02:48:18,208
THAT.

3752
02:48:18,208 --> 02:48:23,680
AS WELL AS HOW TO REVIEW GRANTS.

3753
02:48:23,680 --> 02:48:29,853
AND NOW -- THEY GET INVITED TO

3754
02:48:29,853 --> 02:48:33,323
WEBINAR AND CONFERENCES SO THEY

3755
02:48:33,323 --> 02:48:36,092
ARE AN INTEGRAL PART AND PART OF

3756
02:48:36,092 --> 02:48:38,428
OUR DNA.

3757
02:48:38,428 --> 02:48:40,197
BUT TRAINING IS NOT ENOUGH.

3758
02:48:40,197 --> 02:48:43,867
WE FELT LIKE WE NEEDED TO

3759
02:48:43,867 --> 02:48:46,603
SURPRISE TOOLS AS WELL SO SUSAN

3760
02:48:46,603 --> 02:48:50,707
G KOMEN WAS NICE ENOUGH TO ALLOW

3761
02:48:50,707 --> 02:48:54,211
US TO ADAPT THEIR TOOLKIT.

3762
02:48:54,211 --> 02:48:59,482
WE HAVE A RAPID REACTOR TOOLKIT.

3763
02:48:59,482 --> 02:49:03,520
WE HAVE PIVOT YouTube SO WE

3764
02:49:03,520 --> 02:49:06,256
ARCHIVE TRAININGS AND OUR

3765
02:49:06,256 --> 02:49:09,926
ADVOCATES PARTICIPATE ON BENCH

3766
02:49:09,926 --> 02:49:13,930
TO BEDSIDE FACEBOOK LIVE.

3767
02:49:13,930 --> 02:49:16,633
WE SHARE NEWSLETTERS AND INVITE

3768
02:49:16,633 --> 02:49:19,669
THE ADVOCATES TO THE CANCER

3769
02:49:19,669 --> 02:49:22,706
CENTER SYMPOSIUM AND ONE OF THE

3770
02:49:22,706 --> 02:49:25,408
FAVORITE WALKS IS THE POSTER

3771
02:49:25,408 --> 02:49:30,080
WALK.

3772
02:49:30,080 --> 02:49:33,383
THE RESEARCHERS LOVE IT.

3773
02:49:33,383 --> 02:49:34,851
THEY HAVE TIME FOR THEMSELVES.

3774
02:49:34,851 --> 02:49:37,320
WE HAVE A PRIVATE FACEBOOK AS

3775
02:49:37,320 --> 02:49:48,064
WELL AS A HAU -- A HANGOUT TIME.

3776
02:49:49,599 --> 02:49:55,839
THE QUESTION WAS -- IF YOU BUILD

3777
02:49:55,839 --> 02:49:57,140
IT WILL THEY COME?

3778
02:49:57,140 --> 02:49:59,609
WE WERE NOT SURE THEY WOULD AND

3779
02:49:59,609 --> 02:50:08,118
IN FACT -- THEY DIDN'T AT FIRST.

3780
02:50:08,118 --> 02:50:10,954
IT WAS STILL JUST A HANDFUL.

3781
02:50:10,954 --> 02:50:13,723
SOME OF THE CLINICIANS DID.

3782
02:50:13,723 --> 02:50:16,059
SO WE DECIDED WE NEEDED TO

3783
02:50:16,059 --> 02:50:17,727
CREATE SOMETHING INNOVATIVE TO

3784
02:50:17,727 --> 02:50:19,929
ALLOW THE RESEARCHERS TO DIP

3785
02:50:19,929 --> 02:50:22,632
THEIR TOE NIECE PATIENT RESEARCH

3786
02:50:22,632 --> 02:50:23,166
ADVOCACY.

3787
02:50:23,166 --> 02:50:25,769
WE CREATED RAPID REACTOR TEAMS

3788
02:50:25,769 --> 02:50:28,571
AND YOU CAN SEE THE FLYER.

3789
02:50:28,571 --> 02:50:33,376
AND WE MODELED IT AFTER THE

3790
02:50:33,376 --> 02:50:34,778
VANDERBILT DESIGN STUDIOS.

3791
02:50:34,778 --> 02:50:38,982
WE NEED TO GET MORE RESEARCHERS

3792
02:50:38,982 --> 02:50:40,784
INVOLVED.

3793
02:50:40,784 --> 02:50:43,386
AND THE RAPID REACTOR TEAMS ARE

3794
02:50:43,386 --> 02:50:44,587
SET UP.

3795
02:50:44,587 --> 02:50:45,322
60 MINUTES.

3796
02:50:45,322 --> 02:50:52,696
WE ASKED TO PROVIDE A BLURB OF

3797
02:50:52,696 --> 02:50:57,167
WHAT THEY WERE GOING TO SAY.

3798
02:50:57,167 --> 02:50:59,069
WE ASKED THE RESEARCHER TO

3799
02:50:59,069 --> 02:51:02,806
CREATE A POWER POINT THAT SHARES

3800
02:51:02,806 --> 02:51:04,908
THEIR SCIENCE WITH FIVE SLIDES

3801
02:51:04,908 --> 02:51:07,110
AND WE GIVE THEM THE TEMPLATE

3802
02:51:07,110 --> 02:51:08,978
AND WE GIVE THEM FEEDBACK.

3803
02:51:08,978 --> 02:51:10,947
USUALLY A COUPLE OF TIMES.

3804
02:51:10,947 --> 02:51:12,549
STILL TOO COMPLICATED.

3805
02:51:12,549 --> 02:51:15,118
YOU HAD SOME GREAT EXAMPLES OF

3806
02:51:15,118 --> 02:51:17,387
GOOD SLIDES HERE TODAY BUT WE

3807
02:51:17,387 --> 02:51:20,357
DID NEED -- WE NEED TO

3808
02:51:20,357 --> 02:51:21,424
CONTINUALLY WORK WITH THE

3809
02:51:21,424 --> 02:51:23,059
RESEARCHERS ON HOW TO PRESENT.

3810
02:51:23,059 --> 02:51:25,362
WE HAVE ALLOW THE RESEARCHERS TO

3811
02:51:25,362 --> 02:51:29,232
TALK FOR 10-15 MINUTES AND THEN

3812
02:51:29,232 --> 02:51:30,800
FACILITATE A CONVERSATION WITH

3813
02:51:30,800 --> 02:51:36,206
THE AD -- ADDS VACATES.

3814
02:51:36,206 --> 02:51:39,509
-- ADVOCATES.

3815
02:51:39,509 --> 02:51:41,478
SO WE FACILITATE THAT

3816
02:51:41,478 --> 02:51:43,813
CONVERSATION SO THAT THEY BOTH

3817
02:51:43,813 --> 02:51:46,316
GET SOMETHING OUT OF THE

3818
02:51:46,316 --> 02:51:47,417
PRESENTATIONS AND IT DOES HELP

3819
02:51:47,417 --> 02:51:49,853
THE RESEARCHERS PRIORITIZE

3820
02:51:49,853 --> 02:51:51,421
TOPICS, HONE THEIR RESEARCH

3821
02:51:51,421 --> 02:51:52,489
STRATEGY.

3822
02:51:52,489 --> 02:51:55,091
THINK ABOUT ELIGIBILITY

3823
02:51:55,091 --> 02:51:57,794
CRITERIA, THE BURDEN OF THE

3824
02:51:57,794 --> 02:51:58,395
PARTICIPATING.

3825
02:51:58,395 --> 02:52:00,964
CAN I GET THAT BLOOD DRAWN

3826
02:52:00,964 --> 02:52:03,233
LOCALLY VERSUS DRIVING IN AND

3827
02:52:03,233 --> 02:52:04,501
STRENGTHEN RECRUITMENT AND

3828
02:52:04,501 --> 02:52:11,541
RETENTION.

3829
02:52:11,541 --> 02:52:14,744
AND THE RESEARCHERS ARE

3830
02:52:14,744 --> 02:52:16,813
EVALUATING THEIR EXPERIENCES.

3831
02:52:16,813 --> 02:52:20,683
WE HAVE THE ADVOCATES THAT

3832
02:52:20,683 --> 02:52:22,185
EVALUATE AFTERWARDS AND THE

3833
02:52:22,185 --> 02:52:23,386
RESEARCHERS HAVE SAID THAT IT

3834
02:52:23,386 --> 02:52:25,088
HELPS THEM TO UNDERSTAND THE

3835
02:52:25,088 --> 02:52:26,523
PATIENT VOICE.

3836
02:52:26,523 --> 02:52:29,726
AS YOU CAN SEE 14% INCREASED

3837
02:52:29,726 --> 02:52:30,994
SENSITIVITY.

3838
02:52:30,994 --> 02:52:34,130
28% FEEDBACK ON FEASIBILITY.

3839
02:52:34,130 --> 02:52:37,267
THESE ARE REALLY IMPORTANT

3840
02:52:37,267 --> 02:52:39,202
PROJECT APPROPRIATENESS.

3841
02:52:39,202 --> 02:52:41,738
THEY COME BACK RAVING ABOUT THE

3842
02:52:41,738 --> 02:52:46,242
OPPORTUNITY.

3843
02:52:46,242 --> 02:52:47,977
BUT THEN IT WAS BASIC

3844
02:52:47,977 --> 02:52:52,782
SCIENTISTS.

3845
02:52:52,782 --> 02:52:56,419
DR. LEWIS WANTED TO SPEAK US TO.

3846
02:52:56,419 --> 02:52:58,221
I DON'T KNOW HOW THEY WILL

3847
02:52:58,221 --> 02:52:59,756
INTERACT.

3848
02:52:59,756 --> 02:53:01,524
BUT SHE PROVIDED A PRESENTATION

3849
02:53:01,524 --> 02:53:04,494
ON HER SCIENCE THAT WAS SPECIFIC

3850
02:53:04,494 --> 02:53:06,930
TO -- TRIPLE NEGATIVE BREAST

3851
02:53:06,930 --> 02:53:11,501
CANCER AND TALKED ABOUT

3852
02:53:11,501 --> 02:53:13,002
INFLAMMATION AND THEN STARTED

3853
02:53:13,002 --> 02:53:14,904
ASKING QUESTIONS ABOUT WHAT DOES

3854
02:53:14,904 --> 02:53:16,406
THAT MEAN FOR AFRICAN-AMERICAN

3855
02:53:16,406 --> 02:53:18,708
WOMEN AND AN OPPORTUNITY TO

3856
02:53:18,708 --> 02:53:29,385
ADDRESS THIS I'M F ---I'M FLAT S

3857
02:53:29,385 --> 02:53:32,922
AND THEN WAS FUNDED FOR IT.

3858
02:53:32,922 --> 02:53:35,725
* MY PERFECT SPENCE IS HIGHLY

3859
02:53:35,725 --> 02:53:46,135
INFLUENCED BY RESEARCH.

3860
02:53:53,042 --> 02:54:03,486
-- AND WE'RE HOPING FROM THAT

3861
02:54:07,490 --> 02:54:11,528
RAPID REACTOR TEAMS WE CAN HONE

3862
02:54:11,528 --> 02:54:13,396
AND CREATE PATIENT PARTNERSHIPS

3863
02:54:13,396 --> 02:54:15,665
BEYOND THESE ONE TIME TOUCHES

3864
02:54:15,665 --> 02:54:17,901
BUT WE HAD NOT GOTTEN TO THAT

3865
02:54:17,901 --> 02:54:19,168
LEVEL YET.

3866
02:54:19,168 --> 02:54:23,139
SO AND PARTLY BECAUSE

3867
02:54:23,139 --> 02:54:24,707
RESEARCHERS WERE NOT QUITE SURE

3868
02:54:24,707 --> 02:54:26,676
HOW TO INTERACT WITH THE

3869
02:54:26,676 --> 02:54:28,778
ADVOCATES SO WE CREATED -- WE

3870
02:54:28,778 --> 02:54:31,314
SHARED THE TOOLKIT WITH THEM.

3871
02:54:31,314 --> 02:54:33,283
WE HAVE THEM PRESENT ON THE

3872
02:54:33,283 --> 02:54:35,518
WEBINAR AND WE HELP THEM

3873
02:54:35,518 --> 02:54:36,786
COMMUNICATE BEFORE THE WEBINAR.

3874
02:54:36,786 --> 02:54:40,156
WE PROVIDE ONE-ON-ONE COACHING.

3875
02:54:40,156 --> 02:54:42,559
FACILITATE A DISCUSSION AND HELP

3876
02:54:42,559 --> 02:54:45,595
THEM WITH THEIR SUMMARY.

3877
02:54:45,595 --> 02:54:48,631
BUT WE STILL WERE NOT GETTING

3878
02:54:48,631 --> 02:54:50,033
THE SAME LEVEL OF INTERACTION

3879
02:54:50,033 --> 02:54:52,302
WITH THE BASIC SCIENTISTS.

3880
02:54:52,302 --> 02:54:55,204
SO WE WERE THRILLED WHEN THE

3881
02:54:55,204 --> 02:54:58,074
OFFICE -- RELEASESSED THAT CALL

3882
02:54:58,074 --> 02:55:02,111
FOR THE BASIC SCIENTIST PROGRAM.

3883
02:55:02,111 --> 02:55:02,312
*.

3884
02:55:02,312 --> 02:55:04,213
WE WERE AT THE POINT WHERE WE

3885
02:55:04,213 --> 02:55:07,116
COULD LAUNCH OFF AND CREATE

3886
02:55:07,116 --> 02:55:07,650
SOMETHING EXCITING.

3887
02:55:07,650 --> 02:55:09,919
AND WE WERE LUCKY TO RECEIVE ONE

3888
02:55:09,919 --> 02:55:12,388
OF THE SUPPLEMENTS.

3889
02:55:12,388 --> 02:55:14,257
WE CREATED A NINE MONTH

3890
02:55:14,257 --> 02:55:18,161
TRAINING.

3891
02:55:18,161 --> 02:55:20,463
IT WAS SELECTIVE PROCESS.

3892
02:55:20,463 --> 02:55:22,465
NOT EVERYBODY WHO WANTED TO

3893
02:55:22,465 --> 02:55:24,601
PARTICIPATE WAS ALLOWED TO AND

3894
02:55:24,601 --> 02:55:26,603
THAT GAINED SOME EXCITEMENT THEN

3895
02:55:26,603 --> 02:55:28,805
SO OTHERS NOW WANT TO

3896
02:55:28,805 --> 02:55:29,806
PARTICIPATE.

3897
02:55:29,806 --> 02:55:31,574
WE STARTED OUT WITH PRINCIPLES

3898
02:55:31,574 --> 02:55:34,277
OF COMMUNITY ENGAGEMENT AND

3899
02:55:34,277 --> 02:55:36,245
PRINCIPLES OF RESEARCH PATIENT

3900
02:55:36,245 --> 02:55:36,779
ENGAGEMENT.

3901
02:55:36,779 --> 02:55:39,349
THOSE LOOK DIFFERENT AND THEN ON

3902
02:55:39,349 --> 02:55:43,119
TO SHARED COMMUNICATION SKILLS.

3903
02:55:43,119 --> 02:55:44,454
WE CONTRACTED OUT WITH THE

3904
02:55:44,454 --> 02:55:46,422
CENTER FOR COMMUNICATING

3905
02:55:46,422 --> 02:55:48,324
SCIENCE.

3906
02:55:48,324 --> 02:55:53,162
AND THEN DID SOME -- TEAM

3907
02:55:53,162 --> 02:55:55,331
BUILDING -- HAVING INDIVIDUAL

3908
02:55:55,331 --> 02:55:57,767
MEETINGS.

3909
02:55:57,767 --> 02:56:01,337
WE HAD THEM NEGOTIATE HOW TO BE

3910
02:56:01,337 --> 02:56:01,604
PARTNERS.

3911
02:56:01,604 --> 02:56:03,906
AND THEN WE SAID OKAY NOW YOU'RE

3912
02:56:03,906 --> 02:56:06,142
GOING TO MEET ONCE A MONTH WITH

3913
02:56:06,142 --> 02:56:07,577
US AND WE'LL TEACH YOU SKILLS

3914
02:56:07,577 --> 02:56:10,413
AND YOU WILL GO OUT ONCE A MONTH

3915
02:56:10,413 --> 02:56:13,583
VIRTUALLY OR OTHERWISE AND

3916
02:56:13,583 --> 02:56:14,984
ENGAGE EACH OTHER ON THE

3917
02:56:14,984 --> 02:56:15,985
RESEARCH.

3918
02:56:15,985 --> 02:56:18,588
AND WE KNEW -- AND WE WANT YOU

3919
02:56:18,588 --> 02:56:23,693
TO END WITH PRESENTING AT THE

3920
02:56:23,693 --> 02:56:26,763
SYMPOSIUM.

3921
02:56:26,763 --> 02:56:29,532
AND WE KNEW WE WERE SUCCESSFUL

3922
02:56:29,532 --> 02:56:32,435
WHEN ADVOCATES HAD TO PRESENT

3923
02:56:32,435 --> 02:56:35,238
THEIR SCIENCE PARTNER THEIR

3924
02:56:35,238 --> 02:56:37,473
RESEARCH PARTNER AND THEY DID AN

3925
02:56:37,473 --> 02:56:39,609
AMAZING JOB SO THAT MEANT THEY

3926
02:56:39,609 --> 02:56:45,882
WERE TRULY COMMUNICATING.

3927
02:56:45,882 --> 02:56:48,384
AND WHEN WE ASKED THE SCIENTISTS

3928
02:56:48,384 --> 02:56:52,622
AND THE ADVOCATES TO ASSESS THE

3929
02:56:52,622 --> 02:56:54,090
COMMUNICATION SKILLS WE FOUND

3930
02:56:54,090 --> 02:56:57,193
THAT THE ADVOCATES FELT AND THE

3931
02:56:57,193 --> 02:56:58,728
SCIENTISTS AGREED THAT THE

3932
02:56:58,728 --> 02:57:00,797
RESEARCHER HAD IMPROVED THEIR

3933
02:57:00,797 --> 02:57:02,732
COMMUNICATION SKILLS.

3934
02:57:02,732 --> 02:57:05,535
THEY TALKED ABOUT HOW THEY

3935
02:57:05,535 --> 02:57:07,870
INCORPORATED ADVOCATES AND

3936
02:57:07,870 --> 02:57:09,072
FUNDED PROPOSALS.

3937
02:57:09,072 --> 02:57:11,340
THEY WANT TO CONTINUE TO PARTNER

3938
02:57:11,340 --> 02:57:13,743
WITH THESE ADDS VACATES AND

3939
02:57:13,743 --> 02:57:17,313
TONYA IS THERE WITH HER RESEARCH

3940
02:57:17,313 --> 02:57:20,650
PARTNER.

3941
02:57:20,650 --> 02:57:31,027
DR. GUNN IS AN MD-PhD.

3942
02:57:33,730 --> 02:57:35,565
AND THEY ALSO SAID THEY WANT

3943
02:57:35,565 --> 02:57:38,634
OTHER SCIENTISTS TO PARTICIPATE

3944
02:57:38,634 --> 02:57:41,871
IN THE PIVOT PROGRAM.

3945
02:57:41,871 --> 02:57:44,640
AND OVER-ALL OUR PIVOT OUTCOMES

3946
02:57:44,640 --> 02:57:46,743
HAVE TO ENGAGED MORE THAN 80

3947
02:57:46,743 --> 02:57:48,077
RESEARCHERS NOW.

3948
02:57:48,077 --> 02:57:49,779
SO WE ARE STARTING TO ENGAGE

3949
02:57:49,779 --> 02:57:50,980
RESEARCHERS.

3950
02:57:50,980 --> 02:57:53,049
WE'VE SUPPORTED OVER 65

3951
02:57:53,049 --> 02:57:53,616
PROPOSALS.

3952
02:57:53,616 --> 02:57:56,419
AND WE'VE HAD SUCCESSFUL FUNDED

3953
02:57:56,419 --> 02:57:58,921
PROPOSALS THAT ARE PILOT GRANTS.

3954
02:57:58,921 --> 02:58:00,189
DEPARTMENT OF DEFENSE GRANTS.

3955
02:58:00,189 --> 02:58:04,660
ONE OF THE BIGGEST WINS WAS --

3956
02:58:04,660 --> 02:58:06,262
THEY RECEIVED COMMENTS BACK

3957
02:58:06,262 --> 02:58:08,131
ABOUT HOW OBVIOUS IT WAS THAT

3958
02:58:08,131 --> 02:58:11,334
THE PATIENT RESEARCH ADVOCATE

3959
02:58:11,334 --> 02:58:16,005
WAS PART OF THEIR DEVELOPMENT OF

3960
02:58:16,005 --> 02:58:22,145
THEIR PROJECT AND WE POSTED OVER

3961
02:58:22,145 --> 02:58:23,112
47 SESSIONS.

3962
02:58:23,112 --> 02:58:25,782
THE LESSONS LEARNED IS THAT

3963
02:58:25,782 --> 02:58:27,583
PARTNERSHIPS REQUIRE INTENTIONAL

3964
02:58:27,583 --> 02:58:29,552
INTERACTIONS AND THEY DO TAKE

3965
02:58:29,552 --> 02:58:30,820
TIME BUT THEY SPEED UP THE

3966
02:58:30,820 --> 02:58:33,089
SCIENCE SO THE TIMES WELL WORTH

3967
02:58:33,089 --> 02:58:34,757
IT IF IT'S SPEEDING UP THE

3968
02:58:34,757 --> 02:58:37,026
SCIENCE BUT WE HAVE TO REMIND

3969
02:58:37,026 --> 02:58:38,795
THE RESEARCHER WHEN THEIR HEADS

3970
02:58:38,795 --> 02:58:41,097
ARE DOWN TO LOOK UP AND REACH

3971
02:58:41,097 --> 02:58:43,065
OUT TO THEIR PATIENT PARTNERS.

3972
02:58:43,065 --> 02:58:48,137
WE ALSO KNOW THAT TOPICS CAN BE

3973
02:58:48,137 --> 02:58:50,406
TRAUMATIZING.

3974
02:58:50,406 --> 02:58:56,679
CANCERRING CHALLENGING.

3975
02:58:56,679 --> 02:59:06,088
OR HEARING ABOUT -- IT WAS

3976
02:59:06,088 --> 02:59:07,757
CHALLENGING SO WE DECIDED TO

3977
02:59:07,757 --> 02:59:10,693
INCLUDE -- WE HAVE A LICENSED

3978
02:59:10,693 --> 02:59:12,228
CLINICAL SOCIAL WORKER ON OUR

3979
02:59:12,228 --> 02:59:15,698
TEAM AND WE DID A WEBINAR ON HOW

3980
02:59:15,698 --> 02:59:17,400
TO CREATE SPACE AND SUPPORT

3981
02:59:17,400 --> 02:59:18,701
YOURSELF AND OTHERS AND CONTINUE

3982
02:59:18,701 --> 02:59:20,970
TO CHECK-IN WITH THE ADVOCATES

3983
02:59:20,970 --> 02:59:23,005
IN THE AREA AND THEN RESEARCH

3984
02:59:23,005 --> 02:59:26,909
CAREERS ARE FLUID AND THEY

3985
02:59:26,909 --> 02:59:29,579
INVOLVE CHANGING INSTITUTIONS.

3986
02:59:29,579 --> 02:59:31,214
WE'RE ASKING TO MATCH PEOPLE

3987
02:59:31,214 --> 02:59:33,282
THAT MAYBE ARE NOT A GOOD MATCH

3988
02:59:33,282 --> 02:59:35,785
SO WE NEED TO CONTINUALLY WORK

3989
02:59:35,785 --> 02:59:38,087
WITH BOTH THE ADVOCATE AND THE

3990
02:59:38,087 --> 02:59:39,889
RESEARCHER TO MAKE SURE THEIR

3991
02:59:39,889 --> 02:59:44,093
NEEDS ARE BEING MET.

3992
02:59:44,093 --> 02:59:46,863
COMMUNICATE RESPECTFULLY.

3993
02:59:46,863 --> 02:59:48,998
AND IF THEY ARE GOING TO SHARE

3994
02:59:48,998 --> 02:59:53,669
THAT AND COMMUNICATE THAT -- --

3995
02:59:53,669 --> 02:59:55,271
WE'LL MATCH WITH ANOTHER

3996
02:59:55,271 --> 02:59:57,340
ADVOCATE.

3997
02:59:57,340 --> 02:59:58,808
THOSE ARE SOME OF THE LESSONS

3998
02:59:58,808 --> 02:59:59,041
LEARNED.

3999
02:59:59,041 --> 03:00:00,810
THERE IS A TON OF PATIENT

4000
03:00:00,810 --> 03:00:02,612
RESEARCH ADVOCATES THAT CAN GIVE

4001
03:00:02,612 --> 03:00:04,714
A COLLECTIVE VOICE TO SCIENCE

4002
03:00:04,714 --> 03:00:07,717
AND IT WILL MAKE A DIFFERENCE.

4003
03:00:07,717 --> 03:00:12,188
SO AGAIN I STARTED AND I WANTED

4004
03:00:12,188 --> 03:00:17,026
TO END -- THIS IS NOT MY WORK.

4005
03:00:17,026 --> 03:00:19,228
AND WE HAD THE LEADERSHIP OF THE

4006
03:00:19,228 --> 03:00:20,029
CANCER CENTER WITH THE

4007
03:00:20,029 --> 03:00:21,364
RESEARCHERS AND THE DIRECTORS

4008
03:00:21,364 --> 03:00:23,232
AND THE COMMUNITY ADVISORY BOARD

4009
03:00:23,232 --> 03:00:26,769
AND THE STAFF AND KU CANCER

4010
03:00:26,769 --> 03:00:27,503
CENTER FACULTY.

4011
03:00:27,503 --> 03:00:28,738
I WANT TO ACKNOWLEDGE THEIR

4012
03:00:28,738 --> 03:00:31,741
WORK.

4013
03:00:31,741 --> 03:00:34,143
AND FEEL BLESSED TO BE PART OF

4014
03:00:34,143 --> 03:00:37,613
THIS MISSION.

4015
03:00:37,613 --> 03:00:40,716
AND THAT IS BASICALLY IT.

4016
03:00:40,716 --> 03:00:42,418
REACHING MORE PEOPLE AND SAVING

4017
03:00:42,418 --> 03:00:43,019
MORE LIVES.

4018
03:00:43,019 --> 03:00:44,787
YOU HAVE TO HAVE AT LEAST ONE OF

4019
03:00:44,787 --> 03:00:45,554
THEM.

4020
03:00:45,554 --> 03:00:47,356
SORRY I WENT SO FAST BUT I

4021
03:00:47,356 --> 03:00:49,025
WANTED TO MAKE SURE I GAVE YOU

4022
03:00:49,025 --> 03:00:54,530
TIME TO ASK QUESTIONS.

4023
03:00:54,530 --> 03:00:55,798
>> EXCELLENT PRESENTATION.

4024
03:00:55,798 --> 03:00:57,133
REALLY APPRECIATE THAT AND

4025
03:00:57,133 --> 03:00:59,335
YOU'VE DONE SOME AMAZING WORK IN

4026
03:00:59,335 --> 03:01:01,470
KANSAS.

4027
03:01:01,470 --> 03:01:03,472
SO WHAT QUESTIONS?

4028
03:01:03,472 --> 03:01:05,641
ANNIE, YOU WANT TO GO FIRST?

4029
03:01:05,641 --> 03:01:06,208
>> SURE.

4030
03:01:06,208 --> 03:01:11,948
THANK YOU SO MUCH, AN AMAZING

4031
03:01:11,948 --> 03:01:13,282
PRESENTATION ABOUT THE WORK

4032
03:01:13,282 --> 03:01:17,053
YOU'VE DONE AND IS IT TONYA.

4033
03:01:17,053 --> 03:01:18,554
THANK YOU FOR BEING HERE AND

4034
03:01:18,554 --> 03:01:19,288
YOUR WORK.

4035
03:01:19,288 --> 03:01:22,124
I WOULD LIKE TO HEAR ABOUT YOUR

4036
03:01:22,124 --> 03:01:23,426
IMPRESSIONS AND CONTRIBUTIONS

4037
03:01:23,426 --> 03:01:25,895
AND WHAT YOU'RE MOST PROUD OF.

4038
03:01:25,895 --> 03:01:28,230
MY QUESTION IS -- AND AGAIN

4039
03:01:28,230 --> 03:01:31,000
AMAZING WORK.

4040
03:01:31,000 --> 03:01:33,069
DID YOUR PATIENTLY RESEARCH

4041
03:01:33,069 --> 03:01:34,971
PARTNERS NEED TO BE PROCESSED BY

4042
03:01:34,971 --> 03:01:38,374
THE CANCER CENTER AS VOLUNTEERS?

4043
03:01:38,374 --> 03:01:40,609
WAS THERE AN INTAKE SYSTEM AND

4044
03:01:40,609 --> 03:01:44,347
DID THAT CREATE A BARRIER TO

4045
03:01:44,347 --> 03:01:45,448
PARTICIPATE INCOME PIVOT?

4046
03:01:45,448 --> 03:01:47,783
HOW DID YOU GET AROUND THAT?

4047
03:01:47,783 --> 03:01:50,920
AND HOW DO YOU HANDLE MULTIPLE

4048
03:01:50,920 --> 03:01:52,521
REQUEST FOR THE SAME CANISTER

4049
03:01:52,521 --> 03:01:56,959
TYPE?

4050
03:01:56,959 --> 03:01:59,495
-- CANCER -- TYPE

4051
03:01:59,495 --> 03:02:01,897
>> THE ADVOCATES DO NOT
HAVE TO

4052
03:02:01,897 --> 03:02:04,300
GO THROUGH A SPECIFIC PROCESS OF

4053
03:02:04,300 --> 03:02:05,201
ON-BOARDING THEM.

4054
03:02:05,201 --> 03:02:07,870
THEY COME DIRECTLY THROUGH

4055
03:02:07,870 --> 03:02:08,404
PIVOT.

4056
03:02:08,404 --> 03:02:10,239
WE DO NOT PAY THEM AS STAFF

4057
03:02:10,239 --> 03:02:11,140
MEMBERS.

4058
03:02:11,140 --> 03:02:12,675
THEY ARE NOT PART OF THE CANCER

4059
03:02:12,675 --> 03:02:14,744
CENTER AND WE THOUGHT THAT WAS

4060
03:02:14,744 --> 03:02:15,911
AN IMPORTANT ASPECT.

4061
03:02:15,911 --> 03:02:18,080
WE PROVIDE CONSULTATION FEES TO

4062
03:02:18,080 --> 03:02:19,415
THE ADVOCATES.

4063
03:02:19,415 --> 03:02:22,785
WE FEEL IT'S IMPORTANT TO PAY

4064
03:02:22,785 --> 03:02:28,591
THE ADVOCATES FOR THEIR TIME.

4065
03:02:28,591 --> 03:02:30,693
AT THIS POINT IT HAS NOT BEEN A

4066
03:02:30,693 --> 03:02:32,461
BARRIER WITH OUR CANCER CENTER.

4067
03:02:32,461 --> 03:02:35,331
WE GET LOTS OF SPECIFIC CANCER

4068
03:02:35,331 --> 03:02:36,032
REQUESTS.

4069
03:02:36,032 --> 03:02:38,000
WE'VE DECIDED AND WE DON'T WANT

4070
03:02:38,000 --> 03:02:40,803
TO BE A VENDING MACHINE SO WE'RE

4071
03:02:40,803 --> 03:02:43,739
TRYING TO WORK -- HOW DO WE

4072
03:02:43,739 --> 03:02:46,242
REALLY HELP THOSE RESEARCHERS

4073
03:02:46,242 --> 03:02:48,644
THINK ABOUT WHO WOULD BE A GOOD

4074
03:02:48,644 --> 03:02:50,012
PARTNER AND WE CANNOT ALWAYS

4075
03:02:50,012 --> 03:02:55,518
MATCH THE SPECIFIC CANCER TO THE

4076
03:02:55,518 --> 03:02:55,985
RESEARCHER.

4077
03:02:55,985 --> 03:02:59,088
BUT OFTEN THE ADVOCATES HAVE AN

4078
03:02:59,088 --> 03:03:01,157
OVER ARCHING EXPERIENCE AND THEN

4079
03:03:01,157 --> 03:03:02,758
WE WORK WITH THE RESEARCHERS

4080
03:03:02,758 --> 03:03:04,293
SAYING IF THIS IS YOUR AREA OF

4081
03:03:04,293 --> 03:03:06,395
RESEARCH LET'S FIND CLINICIANS

4082
03:03:06,395 --> 03:03:07,563
DOING THAT AND HELP YOU HAVE

4083
03:03:07,563 --> 03:03:11,801
FIND THAT INFORMATION.

4084
03:03:11,801 --> 03:03:14,437
WITH 130 ADVOCATES AND NOT ALL

4085
03:03:14,437 --> 03:03:15,805
OF THEM PARTNER.

4086
03:03:15,805 --> 03:03:17,440
SOME JUST WANT EDUCATION BUT

4087
03:03:17,440 --> 03:03:18,941
THERE IS A LARGE NUMBER THAT

4088
03:03:18,941 --> 03:03:20,443
WANT TO PARTNER.

4089
03:03:20,443 --> 03:03:23,079
SO WE'RE PRETTY LUCKY IN THAT

4090
03:03:23,079 --> 03:03:23,245
PART

4091
03:03:23,245 --> 03:03:25,614
>> THANK YOU AND I'M
HOPEFUL

4092
03:03:25,614 --> 03:03:27,983
SOME DAY ONE OF YOUR PIVOT

4093
03:03:27,983 --> 03:03:29,785
RESEARCH PARTNERS WILL BE A

4094
03:03:29,785 --> 03:03:32,755
MEMBER OF OUR NCRA.

4095
03:03:32,755 --> 03:03:35,724
>> WE WOULD LOVE THAT.

4096
03:03:35,724 --> 03:03:37,927
>> I DIDN'T KNOW IF TONYA
WANTED

4097
03:03:37,927 --> 03:03:40,296
TO SHARE ANYTHING BEFORE I

4098
03:03:40,296 --> 03:03:42,098
SPOKE.

4099
03:03:42,098 --> 03:03:44,100
>> SO FOR THE PATIENT
ADVOCATED

4100
03:03:44,100 --> 03:03:46,702
TO PARTNER WITH THE RESEARCHER

4101
03:03:46,702 --> 03:03:48,804
PARTICULARLY THROUGH THE RAPID

4102
03:03:48,804 --> 03:03:53,109
REACTOR IT'S A WAY THAT THE -- I

4103
03:03:53,109 --> 03:03:55,277
THINK YOU INITIALLY FOR THE

4104
03:03:55,277 --> 03:03:58,414
ADVOCATE WHEN THE SCIENTIST THE

4105
03:03:58,414 --> 03:04:01,450
RESEARCH SCIENTISTS SAID THIS IS

4106
03:04:01,450 --> 03:04:04,720
WHAT I NEED WORK WITH AND THEN

4107
03:04:04,720 --> 03:04:06,288
PRESENTED WITH THE SLIDES AND SO

4108
03:04:06,288 --> 03:04:08,257
THEY HAVE A SMALL AMOUNT OF TIME

4109
03:04:08,257 --> 03:04:10,993
TO TALK ABOUT THAT AND THEN THE

4110
03:04:10,993 --> 03:04:13,829
DISCUSSION REALLY IS LED BY THE

4111
03:04:13,829 --> 03:04:16,098
ADVOCATES BY ASKING THE

4112
03:04:16,098 --> 03:04:17,867
QUESTIONS THAT THE RESEARCHER

4113
03:04:17,867 --> 03:04:19,835
HAS NOT EVEN THOUGHT ABOUT IT.

4114
03:04:19,835 --> 03:04:23,706
I WANTED TO SAY THE RESEARCHER

4115
03:04:23,706 --> 03:04:26,308
DOES NOT REALLY WORK IN A CLINIC

4116
03:04:26,308 --> 03:04:27,209
MOST OF THE TIME.

4117
03:04:27,209 --> 03:04:28,611
THEY WORK IN A LAB.

4118
03:04:28,611 --> 03:04:30,346
SO THIS IS AN COMMUNITY FOR THEM

4119
03:04:30,346 --> 03:04:34,416
TO ENGAGE WITH A HUMAN, A REAL

4120
03:04:34,416 --> 03:04:34,783
PERSON.

4121
03:04:34,783 --> 03:04:37,553
TO HAVE THAT HUMAN TOUCH AND

4122
03:04:37,553 --> 03:04:38,654
HUMAN RELATIONSHIP WITH THE WORK

4123
03:04:38,654 --> 03:04:40,990
THAT THEY ARE DOING.

4124
03:04:40,990 --> 03:04:43,325
SO THEY ARE VERY APPRECIATIVE OF

4125
03:04:43,325 --> 03:04:47,363
THOSE PIECES AS WELL.

4126
03:04:47,363 --> 03:04:51,066
SO THERE ARE WINS ON BOTH SIDES.

4127
03:04:51,066 --> 03:04:54,803
>> THANK YOU SO MUCH.

4128
03:04:54,803 --> 03:04:55,571
>> YES.

4129
03:04:55,571 --> 03:04:55,804
THANKS.

4130
03:04:55,804 --> 03:04:57,973
I JUST WANTED TO THANK YOU HOPE.

4131
03:04:57,973 --> 03:05:02,978
THAT WAS A GREAT PRESENTATION.

4132
03:05:02,978 --> 03:05:05,047
WE'RE EXCITED FOR YOU TO SPEAK

4133
03:05:05,047 --> 03:05:06,916
AT OUR ANNUAL MEETING IN OCTOBER

4134
03:05:06,916 --> 03:05:08,184
ON PATIENT ENGAGEMENT.

4135
03:05:08,184 --> 03:05:10,486
THIS IS A GREAT EXAMPLE OF THE

4136
03:05:10,486 --> 03:05:14,423
PIVOT PROGRAM.

4137
03:05:14,423 --> 03:05:17,126
AND AS DR. VANDER POOL

4138
03:05:17,126 --> 03:05:19,528
HIGHLIGHTED THESE CASE STUDIES

4139
03:05:19,528 --> 03:05:22,264
WE ACTUALLY AT AACI HEARD FROM

4140
03:05:22,264 --> 03:05:24,767
OUR CANCER CENTERS WHEN THESE

4141
03:05:24,767 --> 03:05:27,036
NEW GUIDELINES CAME OUT THAT

4142
03:05:27,036 --> 03:05:29,572
THEY WANTED TO HAVE A LISTSERVE

4143
03:05:29,572 --> 03:05:31,907
AND FORUM WHERE THEY COULD

4144
03:05:31,907 --> 03:05:34,009
COMMUNICATE WITH ONE OTHER.

4145
03:05:34,009 --> 03:05:37,379
I WILL CREDIT AMY BECAUSE SHE

4146
03:05:37,379 --> 03:05:39,682
ASKED IF AACI COULD PUT TOGETHER

4147
03:05:39,682 --> 03:05:42,351
A LIST OF WHERE THE CANCER

4148
03:05:42,351 --> 03:05:45,588
CENTERS COULD SHARA AMONG EACH

4149
03:05:45,588 --> 03:05:47,523
OTHER.

4150
03:05:47,523 --> 03:05:50,859
WE'VE ROUND 200 INDIVIDUALS --

4151
03:05:50,859 --> 03:05:54,797
THAT COLLABORATE.

4152
03:05:54,797 --> 03:05:59,101
AND WILL POINT OUT ALSO

4153
03:05:59,101 --> 03:06:01,003
DR. CHRIS LEE -- WILL BE

4154
03:06:01,003 --> 03:06:02,338
PRESENTING AT OUR ANNUAL MEETING

4155
03:06:02,338 --> 03:06:04,506
AS WELL.

4156
03:06:04,506 --> 03:06:06,875
HE IS GOING TO TALK ABOUT FRED

4157
03:06:06,875 --> 03:06:11,213
HUTCHINSON CANCER CENTER'S PLAN

4158
03:06:11,213 --> 03:06:14,917
TO ENHANCE EFFORT AND WILLING TO

4159
03:06:14,917 --> 03:06:17,586
SHARE THE DEI AND THE

4160
03:06:17,586 --> 03:06:19,555
DEVELOPMENT OF THE DEI PROGRAMS

4161
03:06:19,555 --> 03:06:20,689
AND METRICS.

4162
03:06:20,689 --> 03:06:23,525
SO I THINK IT'S REALLY IMPORTANT

4163
03:06:23,525 --> 03:06:24,927
WHAT THE CANCER CENTERS ARE

4164
03:06:24,927 --> 03:06:28,497
DOING AND HAPPY THAT THE NCI HAS

4165
03:06:28,497 --> 03:06:31,133
PRIORITIZED THIS AND WE'RE HAPPY

4166
03:06:31,133 --> 03:06:32,801
TO COLLABORATE.

4167
03:06:32,801 --> 03:06:34,236
WE LOVE SHARING ANYTHING THAT

4168
03:06:34,236 --> 03:06:35,904
YOU WANT TO PROVIDE WITH OUR

4169
03:06:35,904 --> 03:06:36,772
LISTSERVE.

4170
03:06:36,772 --> 03:06:38,407
OUR CENTERS ARE ALWAYS EXCITED

4171
03:06:38,407 --> 03:06:40,009
TO EAT THAT UP.

4172
03:06:40,009 --> 03:06:42,611
I LOVED HEARING ABOUT THE PIVOT

4173
03:06:42,611 --> 03:06:43,412
PROGRAM.

4174
03:06:43,412 --> 03:06:45,414
IT IS JUST ONE EXAMPLE OF ALL OF

4175
03:06:45,414 --> 03:06:47,049
THE GREAT WORK THAT THE CANCER

4176
03:06:47,049 --> 03:06:49,118
CENTERS ARE DOING.

4177
03:06:49,118 --> 03:06:49,718
>> THANK YOU.

4178
03:06:49,718 --> 03:06:52,187
AND I WOULD HAVE TO SAY THAT ALL

4179
03:06:52,187 --> 03:06:55,224
THAT I KNOW I'VE LEARNED FROM MY

4180
03:06:55,224 --> 03:06:56,058
COLLEAGUES AND FROM THE

4181
03:06:56,058 --> 03:06:56,625
COMMUNITY.

4182
03:06:56,625 --> 03:06:58,894
I'VE BEEN PART TAFT COMMUNITY

4183
03:06:58,894 --> 03:06:59,928
SINCE 2003.

4184
03:06:59,928 --> 03:07:02,598
I MAY HAVE MET DR. VANDER POOL

4185
03:07:02,598 --> 03:07:04,400
AT THAT POINT.

4186
03:07:04,400 --> 03:07:06,035
*

4187
03:07:06,035 --> 03:07:08,537
THEY'VE BEEN SHARING AND WE

4188
03:07:08,537 --> 03:07:09,204
SHARE BARK.

4189
03:07:09,204 --> 03:07:11,273
IT'S COMMUNITY OUTREACH AND

4190
03:07:11,273 --> 03:07:13,942
ENGAGEMENT.

4191
03:07:13,942 --> 03:07:16,211
WE LOVE INTERACTING WITH PEOPLE

4192
03:07:16,211 --> 03:07:19,515
SO WE TRY TO BUILD AND GROW AND

4193
03:07:19,515 --> 03:07:20,849
BUILD EACH OTHER UP BECAUSE THAT

4194
03:07:20,849 --> 03:07:23,218
IS THE ONLY WAY WE CAN IMPACT

4195
03:07:23,218 --> 03:07:28,490
THE CANCERS AND CHANGE THE

4196
03:07:28,490 --> 03:07:29,491
TRAJECTORY OF THE DISEASE.

4197
03:07:29,491 --> 03:07:30,392
>> AND I AGREE.

4198
03:07:30,392 --> 03:07:34,830
THANK YOU.

4199
03:07:34,830 --> 03:07:39,001
>> DO WE HAVE ANY MORE

4200
03:07:39,001 --> 03:07:39,601
QUESTIONS?

4201
03:07:39,601 --> 03:07:39,968
EXCELLENT.

4202
03:07:39,968 --> 03:07:41,804
THIS IS A GREAT PRESENTATION.

4203
03:07:41,804 --> 03:07:43,605
IT'S ALWAYS NICE TO BE ABLE TO

4204
03:07:43,605 --> 03:07:44,707
HIGHLIGHT TRAINING PROGRAMS THAT

4205
03:07:44,707 --> 03:07:46,442
ARE HAPPENING IN THE COMMUNITY.

4206
03:07:46,442 --> 03:07:49,445
IT REMINDS US OF VARIOUS ASPECTS

4207
03:07:49,445 --> 03:07:51,780
THAT WE CAN DO AND SUPPORT AND

4208
03:07:51,780 --> 03:07:53,816
IF WE HAVE ADVOCATES THAT WE

4209
03:07:53,816 --> 03:07:55,617
KNOW WHO ARE IN KANSAS WE KNOW

4210
03:07:55,617 --> 03:07:57,453
WHO TO SEND THEM TO.

4211
03:07:57,453 --> 03:07:58,821
THIS WAS A GREAT PRESENTATION.

4212
03:07:58,821 --> 03:08:00,689
THANK YOU SO MUCH FOR JOINING US

4213
03:08:00,689 --> 03:08:02,257
AND SHARING WHAT IS HAPPENING AS

4214
03:08:02,257 --> 03:08:06,795
IT RELATES TO DEVELOPING LOCAL

4215
03:08:06,795 --> 03:08:08,163
CANCER CENTERS RESEARCH

4216
03:08:08,163 --> 03:08:08,697
APPLICANTS

4217
03:08:08,697 --> 03:08:10,332
>> THANK YOU FOR ALL THAT
YOU

4218
03:08:10,332 --> 03:08:10,933
ARE DOING.

4219
03:08:10,933 --> 03:08:12,935
IT IS MAKING A DIFFERENCE AND

4220
03:08:12,935 --> 03:08:14,269
KEEP THOSE VOICES LOUD.

4221
03:08:14,269 --> 03:08:18,574
IT WAS GREAT TO HEAR THEM TODAY.

4222
03:08:18,574 --> 03:08:20,909
>> I LOVE THOSE T-SHIRTS.

4223
03:08:20,909 --> 03:08:23,145
>> WE ALL NEED A SUPER
POWER

4224
03:08:23,145 --> 03:08:24,313
T-SHIRT.

4225
03:08:24,313 --> 03:08:31,587
>> I'LL SEND ONE TO YOU.

4226
03:08:31,587 --> 03:08:33,789
>> IN CLOSING -- AMY I
THINK

4227
03:08:33,789 --> 03:08:35,724
WE'RE WRAPPING UP OUR MEETING AT

4228
03:08:35,724 --> 03:08:36,625
THIS POINT.

4229
03:08:36,625 --> 03:08:37,626
IS THAT CORRECT?

4230
03:08:37,626 --> 03:08:39,194
>> YES.

4231
03:08:39,194 --> 03:08:42,598
SO WE CAN MOVE TO THE FINAL SORT

4232
03:08:42,598 --> 03:08:45,267
OF PORTION WHICH IS WRAP UP AND

4233
03:08:45,267 --> 03:08:46,635
THE ADMINISTRATIVE ITEM OF

4234
03:08:46,635 --> 03:08:50,572
VOTING ON THE MEETING MINUTES.

4235
03:08:50,572 --> 03:08:52,474
>> EXCELLENT.

4236
03:08:52,474 --> 03:08:54,877
>> LET'S -- LET ME PROPOSE
WE

4237
03:08:54,877 --> 03:08:58,013
VOTE TO APPROVE THE MEETING

4238
03:08:58,013 --> 03:09:00,716
MINUTES FOR THE 85th NCRA

4239
03:09:00,716 --> 03:09:01,250
MEETING.

4240
03:09:01,250 --> 03:09:04,153
BOTH WERE INCLUDED IN OUR

4241
03:09:04,153 --> 03:09:06,288
MATERIALS SO I'LL JUST CALL FOR

4242
03:09:06,288 --> 03:09:09,558
A MOTION TO APPROVE.

4243
03:09:09,558 --> 03:09:12,094
>> SO MOVED.

4244
03:09:12,094 --> 03:09:15,531
>> WILL SOMEONE SECOND?

4245
03:09:15,531 --> 03:09:20,402
>> JENNIFER IS SECONDING.

4246
03:09:20,402 --> 03:09:23,272
>> WE CAN APPROVE THOSE
MINUTES

4247
03:09:23,272 --> 03:09:26,108
AND FINALIZE THE MINUTES FOR THE

4248
03:09:26,108 --> 03:09:28,777
85th NCRA MEETING.

4249
03:09:28,777 --> 03:09:30,813
>> I THINK WE NEED TO VOTE

4250
03:09:30,813 --> 03:09:32,948
>> WHO NEEDS TO VOTE.

4251
03:09:32,948 --> 03:09:34,616
EVERYBODY JUST RAISE YOUR HAND

4252
03:09:34,616 --> 03:09:38,821
AND VOTE.

4253
03:09:38,821 --> 03:09:39,588
EXCELLENT.

4254
03:09:39,588 --> 03:09:40,088
OKAY.

4255
03:09:40,088 --> 03:09:42,691
NOW THEY ARE OFFICIALLY

4256
03:09:42,691 --> 03:09:44,693
APPROVED.

4257
03:09:44,693 --> 03:09:47,596
>> I'LL TURN IT OVER TO
ANJEE TO

4258
03:09:47,596 --> 03:09:49,298
CLOSE US OUT BUT I DO WANT TO

4259
03:09:49,298 --> 03:09:51,467
THANK ALL OF YOU FOR YOUR TIME

4260
03:09:51,467 --> 03:09:51,967
TODAY.

4261
03:09:51,967 --> 03:09:53,469
THIS WAS A GREAT MEETING.

4262
03:09:53,469 --> 03:09:55,103
WE COVERED A TREMENDOUS AMOUNT

4263
03:09:55,103 --> 03:09:57,239
IN ONLY A COUPLE OF HOURS AND

4264
03:09:57,239 --> 03:10:00,209
THE DISCUSSION WAS AWESOME.

4265
03:10:00,209 --> 03:10:02,177
A GREAT INTERSECTION OF SCIENCE

4266
03:10:02,177 --> 03:10:05,280
AND PATIENT INPUT.

4267
03:10:05,280 --> 03:10:08,484
AND I CANNOT THANK YOU ENOUGH.

4268
03:10:08,484 --> 03:10:10,552
WE'VE BEEN DOING NCRA FOR A

4269
03:10:10,552 --> 03:10:12,888
NUMBER OF YEARS NOW IT'S REALLY

4270
03:10:12,888 --> 03:10:15,257
HELPFUL AND AWESOME TO SEE HOW

4271
03:10:15,257 --> 03:10:19,161
THE BOARD HAS EVOLVED AND

4272
03:10:19,161 --> 03:10:20,062
PARTICIPATE IN THE MEETINGS

4273
03:10:20,062 --> 03:10:22,297
THREE TIMES A YEAR BECAUSE IT IS

4274
03:10:22,297 --> 03:10:23,265
SO VALUABLE US TO.

4275
03:10:23,265 --> 03:10:25,868
AND I WANT TO THANK ANJEE FOR

4276
03:10:25,868 --> 03:10:31,473
HER TIME OVER THE PAST COUPLE OF

4277
03:10:31,473 --> 03:10:32,241
YEARS.

4278
03:10:32,241 --> 03:10:33,909
SHE HAS BEEN SO HELPFUL AND HAS

4279
03:10:33,909 --> 03:10:35,911
REPRESENTED SO MANY PATIENTS AND

4280
03:10:35,911 --> 03:10:39,381
SO MANY ADVOCATES AS SHE HAS

4281
03:10:39,381 --> 03:10:41,817
HELPED US SHAPE THE MEETINGS AND

4282
03:10:41,817 --> 03:10:47,422
FOCUS ON THE SWEET SPOTS.

4283
03:10:47,422 --> 03:10:49,358
I SAY THIS AT THE TOP OF EACH

4284
03:10:49,358 --> 03:10:51,260
MEETING BUT I CANNOT REITERATE

4285
03:10:51,260 --> 03:10:53,028
ENOUGH.

4286
03:10:53,028 --> 03:10:55,097
I KNOW YOU ARE DOING SO MANY

4287
03:10:55,097 --> 03:10:56,965
DIFFERENT THINGS.

4288
03:10:56,965 --> 03:10:59,101
WE REALLY APPRECIATE IT.

4289
03:10:59,101 --> 03:11:00,435
BECAUSE YOU WERE PULLED IN SO

4290
03:11:00,435 --> 03:11:02,204
MANY DIRECTIONS AND LITTLE SO

4291
03:11:02,204 --> 03:11:04,239
HELPFUL TO US.

4292
03:11:04,239 --> 03:11:14,416
I WANT WANTED TO THAT CAN -- --E

4293
03:11:14,416 --> 03:11:14,883
STAFF.

4294
03:11:14,883 --> 03:11:17,052
THEY ARE WORKING ON THIS MEETING

4295
03:11:17,052 --> 03:11:19,321
AND ON A VARIETY OF OTHER

4296
03:11:19,321 --> 03:11:21,390
ADVOCATE ENGAGEMENT ACTIVITIES.

4297
03:11:21,390 --> 03:11:23,659
SO I WANT TO MAKE SURE THEY

4298
03:11:23,659 --> 03:11:25,894
UNDERSTAND HOW MUCH THEY ARE

4299
03:11:25,894 --> 03:11:28,130
APPRECIATED BOTH WITHIN N

4300
03:11:28,130 --> 03:11:29,965
CONTRADICTION AND OUTSIDE.

4301
03:11:29,965 --> 03:11:31,900
THANK YOU FOR YOUR TIME.

4302
03:11:31,900 --> 03:11:34,036
ANJEE, IF YOU WANT TO CLOSE US

4303
03:11:34,036 --> 03:11:35,337
OUT THAT WOULD BE GREAT.

4304
03:11:35,337 --> 03:11:36,405
OUR NEXT MEETING IS IN

4305
03:11:36,405 --> 03:11:39,808
SEPTEMBER.

4306
03:11:39,808 --> 03:11:46,415
* THAT WILL BE THE NEXT TIME WE

4307
03:11:46,415 --> 03:11:50,752
COME TOGETHER.

4308
03:11:50,752 --> 03:11:52,454
>> IT WAS A GREAT MEETING
TODAY.

4309
03:11:52,454 --> 03:11:55,023
IT WAS A SPOT ON BEING ABLE TO

4310
03:11:55,023 --> 03:11:58,160
HEAR FROM DR. LOWY AND

4311
03:11:58,160 --> 03:12:01,330
DR. CASTLE AND A RESEARCH

4312
03:12:01,330 --> 03:12:03,632
ADVOCACY PROGRAM ALL IN THE SAME

4313
03:12:03,632 --> 03:12:04,232
MEETING.

4314
03:12:04,232 --> 03:12:06,101
IT HAS BEEN A PLEASURE TO CHAIR

4315
03:12:06,101 --> 03:12:08,870
THIS GROUP AND I PASS THE TORCH

4316
03:12:08,870 --> 03:12:10,739
ON TO ANNIE.

4317
03:12:10,739 --> 03:12:11,740
CONGRATULATIONS.

4318
03:12:11,740 --> 03:12:13,609
YOU'RE GOING TO BE GREAT.

4319
03:12:13,609 --> 03:12:15,777
I HOPE TO MEET EVERYONE IN

4320
03:12:15,777 --> 03:12:16,311
PERSON.

4321
03:12:16,311 --> 03:12:18,547
SINCE WE ALL PLANNED A LUNCH

4322
03:12:18,547 --> 03:12:19,047
DATE.

4323
03:12:19,047 --> 03:12:20,549
--

4324
03:12:20,549 --> 03:12:25,053
>> DO YOU KNOW IF
SEPTEMBER WILL

4325
03:12:25,053 --> 03:12:26,855
WE BE IN PERSON?

4326
03:12:26,855 --> 03:12:28,023
>> I DON'T KNOW YES.

4327
03:12:28,023 --> 03:12:28,890
STAY TUNED.

4328
03:12:28,890 --> 03:12:31,093
WE'LL LET US KNOW WELL IN

4329
03:12:31,093 --> 03:12:32,327
ADVANCE.

4330
03:12:32,327 --> 03:12:34,363
MOST OF OUR BOARD MEMBERS HAVE

4331
03:12:34,363 --> 03:12:36,098
REMAINED VIRTUAL.

4332
03:12:36,098 --> 03:12:37,966
OKAY.

4333
03:12:37,966 --> 03:12:39,368
HAVE A GREAT DAY.

4334
03:12:39,368 --> 03:12:41,136
THANK YOU ALL SO MUCH.

4335
03:12:41,136 --> 03:12:51,136
THANK YOU, ANJEE.