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OKAY, I WOULD LIKE TO WELCOME

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THE NCI BOARD, NCAB STAFF AND

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GUESTS AND LIKE TO EXTEND A WARM

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WELCOME TO DR. CAMERON RASMILL

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WHO HAS SUCCESSFULLY

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TRANSITIONED FROM BEING A BSA

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MEMBER TO NCI DIRECTOR AS WE ALL

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KNOW AND I THINK THIS IS HER

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FIRST BOARD MEETING AS NETWORK

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CI DIRECTOR AND IT'S FIRST

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IN-PERSON, FIRST IN-PURPOSE

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YOINT MEETING.

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OKAY, IT'S GREAT TO HAVE YOU AT

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THE HELM CHEM AND I LOOK FORWARD

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TO WORKING WITH YOU.

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SHALL WE?

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>> FOR THOSE WHO DON'T
KNOW

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PAULET, WE ARE SCRIPTED HERE.

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BUT I WILL GO OFF SCRIPT AND

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SAY,--UH OH.

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IT'S OPERATE TO BE HERE IN

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PERSON, AND SEE EVERYBODY IN

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PERSON, BUT I WON'T SAY ANYTHING

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I SHOULDN'T SAY BUT I HAVE  1

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PRIVATE SECTOR LEMMING OF

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WATCHING RARK SMILL CALLING

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PASHTS AT 10:00 O'CLOCK AT NIGHT

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AFTER FINISHING PATIENTS IN THE

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LAB.

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WHAT I CAN TELL YOU IN AITITION

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TO HER MANY ADMINISTRATIVE

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STANDARDS AND HER COURAGE IN

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TAKING ON THIS JOB AT THIS TIME,

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IT'S A WONDERFUL COMPASSION AND

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JUST WANT TO SAY THANK YOU. .

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[ APPLAUSE ]

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>> THANKS, SO JUST
REQUIRED

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ANNOUNCEMENTS, MEMBERS OF THE

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PUBLIC WHEN MAY WISH TO EXPRESS

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THEIR VIEWS REGARDING ANY IERK

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TEMS DISCUSSED DURING THIS

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MEETING, MAY DO SO BY WRITING TO

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DR. PAULET GRAY EXECUTIVE

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SECRETARY OF THE BOARDS WITHIN

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10 DAYS FOLLOWING THE MEETING,

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ANY WRITTEN AT THE SAME TIMES OR

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QUESTIONS SUBMITTED BY MEMBERS

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OF THE PUBLIC WILL RECEIVE

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CAREFUL CONSIDERATION.

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AS BOARD MEMBERS, I WOULD LIKE

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TO REMIND YOU THAT YOU MUST

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ABSENT YOURSELF DURING SPECIFIC

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DISCUSSIONS WHENEVER YOU'RE

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PARTICIPATION DELIBERATIONS ON A

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PARTICULAR PRODUCT PROGRAM OR

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OTHER SPECIFIC MATTER WOULD

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CONSITUTE A CONFLICT OF INTEREST

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OR CREATE THE APPEARANCE OR

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PERCEPTION OF 1.

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IT IS INCUMBET UPON OURSELVES TO

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ADVICE THE EXECUTIVE SECRETARY

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AND ABNORMALITIES STEAN FROM ANY

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PARTICIPATION AND DISCUSSION OR

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ACTION REGARDING THAT MATTER.

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CONSIDERING THE CURRENT POLICIES

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GOVERNING CONFLICT OF INTEREST,

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BASED ON FINANCIAL HOLDINGS OF

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SPECIAL GOVERNMENT EMPLOYEES

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WHICH WE ALL ARE AS BOARD

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MEMBERS, WE MUST DEPEND UPON

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OURSELVES TO VOLUNTARILY ABSENT

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OURSELVES DURING ANY AND ALL

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DISCUSSIONS OF MATTERS THAT

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COULD CONCEIVABLY IMPACT THE

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STATUS OF ANY OF THESE HOLDINGS.

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SO WOE HAVE TO TRUST OURSELVES

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AND OUR JUDGMENT IN THESE

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INSTANCES.

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DURING IN CLOSED SESSION, ANY

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MATERIALS OR DISCUSSIONS OF A

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CONFIDENTIAL NATURE DLBED UPON

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TODAY ARE PRIVATE SECTOR LENLED

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INFORMATION AND ARE MADE

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AVAILABLE ON A NEED TO KNOW

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BASIS AND THEY ARE PRIVATE AND

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THEIR CONTENT SHOULD NOT BE

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DIVULGED.

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SO FUTURE MEETINGS ARE LISTED ON

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THE AGENDA AND ARE ON THE CANCER

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.GOV WEBSITE.

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BY LAW A  QUORUM IS REQUIRED FOR

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EACH INSTANCE WHETHER A VOTE MAY

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OCCUR, DURING OPEN OR CLOSING,

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DURING THIS MEETING 23 MEMBERS

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MUST BE PRESENT TO VOICE THEIR

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VOTES.

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SINCE WE CAN'T PREDICT THE TIME

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OR OCCURRENCE OF ANY MOTION, OUR

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PRESENCE IN THE ROOM INCLUDING

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THE VIRTUAL ROOM FOR ALL

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SEGMENTS OF THE MEETING IS

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CRITICAL.

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IT SHOULD BE NOTED THAT WHEN WE

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DO--DO THE CONCEPTS LATER TODAY,

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WHILE BOTH BOARDS CAN

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PARTICIPATE IN THE DISCUSSION,

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ONLY BSA NUMBERS WILL BE COUNTED

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IN THE VOTE, THUS THE QUORUM AT

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THAT TIME WILL BE 13 MEMBERS,

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ADDITIONALLY FOLLOWING THE

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SUBCOMMITTEE REPORTS ONLY NCAB

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MEMBERS WILL BE COUNTED IN THE

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VOTE, ALL BOARD MEMBERS CAN

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PARTICIPATE IN THE DISCUSSION.

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THE QUORUM AT THAT TIME WILL BE

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10, PAULET DO WE HAVE A QUORUM.

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SO FUTURE MEETING DATES ARE IN

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THE BOOKS AND ARE ON THE AGENDA.

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THE NCAB AND NBSA MUST CONFIRM

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THE 2026 MEETING DATES SO THE

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MEMBERS CAN AND SHOULD VOTE, SO

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I WOULD LIKE TO CALL A MOTION TO

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CONFIRM THE 2026 MEETING DATES.

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DISCUSSION.

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SO LET'S VOTE?

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ARE THERE ANY NAYS? 

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ANY ABSTENTIONS IT'SUNE NANOG

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MOUSE, WE ALSO HAVE TO APPROVE

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THE FEBRUARY 2024 NCAB VIRTUAL

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MINUTES AND ONLY NCAB MEMBERS

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SHOULD VOTE.

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I WOULD LIKE TO CALL A MOTION TO

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APPROVE THE MINUTES.

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DISCUSSION PROMPTLY MOVE THE

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SECURITIZATION.

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LET'S VOTE.

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ANY NAYS IN ABSTENTIONS?

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IT'S UNANIMOUS.

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WE ALSO MUST--SHELLY THIS IS

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YOU.

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>> USE THE ME C.

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>> WE ALSO MUST APPROVE
THE

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VIRTUAL MARKETPLACE 20 BSA

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MEETING AND BSA MEMBERS TO VOTE.

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MAY I HAVE A MOTION TO APPROVE?

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>> SECOND.

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>> ARE THERE ANY NAYS?

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ANY ABSTENTIONS?

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OKAY,.

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>> THANKS, SHELLY, ALL
SMART

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PHONES AND SIMILAR DEVICES

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SHOULD BE TURNED OFF OR SET ON

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VIBRATE.

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WHENEVER THESE INSTRUMENTS GO

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OFF, THEY CAN DISTURB THE

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MEETING SO THIS APPLIES TO STAFF

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AS WELL AS OTHER INDIVIDUALS IN

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THE ROOM.

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AND ANYONE ON VIRTUAL, PLEASE

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TURN YOUR MICs OFF AND WE WILL

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POINT TO YOU IF YOU HAVE A

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QUESTION TO UNMUTE YOUR MICs.

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OKAY, SO, WE WILL NOW

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BEGENERATED TODAY'S AGENDA WITH

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THE NCI DIRECTOR'S REPORT THAT

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WILL BE PROVIDED BY

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DR. RATHMELL.

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>> THERE WE GO.

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HOW ABOUT NOW.

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GOOD MORNING.

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LET'S DO THAT, GOOD MORNING.

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OKAY, ALL RIGHT, IT IS SO GOOD

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TO BE HERE.

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I'M REALLY DELIGHTED WE'RE IN

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PERSON AND I WANT TO THANK YOU

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ALL FOR MAKING THE TIME TO COME

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OUT IN PERSON AND TO BE A PART

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OF THIS AMAZING PROGRAM AND TO

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REALLY HELP US BE THE BEST THAT

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WE CAN POSSIBLY BE.

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OKAY, WE WILL TRY THIS AGAIN,

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TRYING TO GO TO THE TOPICS OF

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THE DAY, SO I'VE BEEN IN THE

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ROLE FOR ABOUT 6 MONTHS, SPEND A

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LOT OF TIME LISTENING, LEARNING,

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GATHERING DATA AND REALLY

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FEELING READY TO TART TO MOVE.

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WE WILL TALK ABOUT A BUNCH OF

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THINGS TODAY.

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THERE'S SO MUCH THAT DPZ ON AT

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THE NCI, THE THEMES CAN BE

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ENORMOUS AND YOU WILL SEE WE

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TRIED TO MAKE A GOOD FOCUS FOR

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TODAY'S PRESENTATION TO OVER THE

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COURSE OF A YEAR OF SERVICE WILL

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CALL OUT AS MANY THINGS AS WE

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CAN ACROSS THE NCI.

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WE WILL OF COURSE TALK ABOUT THE

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BUNLET, IT HAS BEEN A CHALERGING

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BUDGET SEASON AND PROMISES TO BE

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MORE THAT'S I THINK SOMETHING

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THIS' REALLY IMPORTANT TO TALK

203
00:08:37,993 --> 00:08:39,427
ABOUT WITH THE BOARD AND WE'LL

204
00:08:39,427 --> 00:08:41,730
ALSO TALK ABOUT MORE HIGHLIGHTS

205
00:08:41,730 --> 00:08:43,965
OF THE OVERALL NCI AND I REALLY

206
00:08:43,965 --> 00:08:45,133
WANT TO EMPHASIZE THE QUESTION

207
00:08:45,133 --> 00:08:48,870
AND ANSWER, I WANT TO HEAR FROM

208
00:08:48,870 --> 00:08:52,641
YOU, HEAR, NOW AND AT OTHER

209
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OPPORTUNITIES AS WELL.

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SO STARTING UP WITH JUST A ROUND

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UP OF SOME OF THE NEWS THAT

212
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FOCUSES ON OUR PEOPLE, WE CAN

213
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TALK ABOUT OUR PEOPLE IN LOTS OF

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00:09:03,585 --> 00:09:06,087
DIFFERENT CONTEXTS, BUT I'M

215
00:09:06,087 --> 00:09:08,823
ACTUALLY TARTING WITH SOME OF

216
00:09:08,823 --> 00:09:10,859
YOU, SO THESE ARE THE NEW NCAB

217
00:09:10,859 --> 00:09:12,594
MEMBERS WHO WILL BE YOINING US

218
00:09:12,594 --> 00:09:14,129
THAT HAVE BEEN PUT FORWARD BY

219
00:09:14,129 --> 00:09:15,764
THE WHITE HOUSE, I'M REALLY

220
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EXCITED TO HAVE THEM JOIN.

221
00:09:17,265 --> 00:09:19,935
YOU WILL GET TO KNOW THEM IN A

222
00:09:19,935 --> 00:09:22,204
FUTURE MEETING BUT YOU CAN SEE

223
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THAT WE HAVE CONTINUED

224
00:09:24,973 --> 00:09:27,142
COMMITMENT TO DIVERSITY,

225
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COMMITMENT TO SURGEON SCIENCE,

226
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COMMITMENT TO COMMUNITY,

227
00:09:32,914 --> 00:09:34,049
COMMITMENT TO COMMUNICATION.

228
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SO REALLY EXCITED TO SEE THESE

229
00:09:36,685 --> 00:09:40,855
FOLKS COMING ON SOON.

230
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WE'LL HAVE NEW MEMBERS TO THE

231
00:09:43,892 --> 00:09:44,759
NCAB, ALSO EVENTUALLY TO OUR

232
00:09:44,759 --> 00:09:45,560
OTHER BOARD AND AMERICANS.

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00:09:45,560 --> 00:09:47,996
WHEN I WAS A BSA MEMBER, I DID

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00:09:47,996 --> 00:09:50,432
NOT KNOW WE HAD 6 BOARDS BUT WE

235
00:09:50,432 --> 00:09:51,733
HAVE 6 ADVISORY OR COMMITTEE

236
00:09:51,733 --> 00:09:52,901
BOARDS TO THE NCI.

237
00:09:52,901 --> 00:09:54,502
WE DID A LOT OF DIFFERENT WORK

238
00:09:54,502 --> 00:09:57,272
AND SO 1 OF THE THINGS THAT

239
00:09:57,272 --> 00:09:58,773
WE'RE GOING TO BE IMPLEMENTING

240
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IN THE NEXT YEAR IS A WHOLISTIC

241
00:10:01,042 --> 00:10:02,744
ORIENTATION TO THE NCI FOR NEW

242
00:10:02,744 --> 00:10:03,812
MEMBERS OF THE BOARDS.

243
00:10:03,812 --> 00:10:05,380
WE HAVE A COMMITTEE THAT'S

244
00:10:05,380 --> 00:10:06,881
PUTTING THIS TOGETHER, I KNOW

245
00:10:06,881 --> 00:10:10,385
YOU ALL GET ORIENTATION TO THE

246
00:10:10,385 --> 00:10:12,153
WORK THAT YOU DO AND THE

247
00:10:12,153 --> 00:10:12,988
EXPECTATIONS OF BOARD MEMBERS,

248
00:10:12,988 --> 00:10:15,457
BUT I THINK TO BE AN EFFECTIVE

249
00:10:15,457 --> 00:10:16,658
BOARD MEMBER IT'S GOD HAVE A

250
00:10:16,658 --> 00:10:17,726
REAL INSIGHT INTO THE THINGS

251
00:10:17,726 --> 00:10:20,729
THAT WE DO HERE AND SO, I MAY BE

252
00:10:20,729 --> 00:10:22,530
PINNING SOME OF YOU FOR IDEAS OR

253
00:10:22,530 --> 00:10:23,665
OTHER PEOPLE ON THE COMMITTEE

254
00:10:23,665 --> 00:10:25,166
MAYBE DOING THAT AS WE PUT

255
00:10:25,166 --> 00:10:29,604
TOGETHER A PLAN FOR A DAY THAT

256
00:10:29,604 --> 00:10:30,972
REALLY EMERCS PEOPLE TOGETHER,

257
00:10:30,972 --> 00:10:32,507
SO WITH NEW BOARD MEMBERS

258
00:10:32,507 --> 00:10:34,242
GETTING TO MEET THE BOARD

259
00:10:34,242 --> 00:10:35,910
MEMBERS FROM THE OTHER BOARDS AS

260
00:10:35,910 --> 00:10:41,316
WELL, SO MORE DETAILS TO COME ON

261
00:10:41,316 --> 00:10:41,549
THAT.

262
00:10:41,549 --> 00:10:43,218
NOW OTHER PEOPLE NEWS, SO THIS

263
00:10:43,218 --> 00:10:45,587
IS ON THE INTRAMURAL PROGRAM, WE

264
00:10:45,587 --> 00:10:48,189
HAVE A FOCUSED ON NOMINAL SET OF

265
00:10:48,189 --> 00:10:49,324
INVESTIGATORS AND INTRAMURAL

266
00:10:49,324 --> 00:10:51,793
PROGRAM, I WANT TO HIGHLIGHT A

267
00:10:51,793 --> 00:10:53,495
FEW WITH NATIONAL ACCOMPLISH

268
00:10:53,495 --> 00:10:57,032
AMS, WE HAVE 3 NEW MEMBERS, WE

269
00:10:57,032 --> 00:11:00,802
HAVE STEVEN GORGE YORE, SANDRA

270
00:11:00,802 --> 00:11:02,270
WALLEN, AND WE HAVE NEW MEMBERS

271
00:11:02,270 --> 00:11:03,471
TO THE AMERICAN ASSOCIATION OF

272
00:11:03,471 --> 00:11:05,473
PHYSICIANS, WE CAN GO ON AND ON

273
00:11:05,473 --> 00:11:06,975
IT'S A FANTASTIC GROUP OF PEOPLE

274
00:11:06,975 --> 00:11:09,844
BUT I WANT TO HIGHLIGHT THESE

275
00:11:09,844 --> 00:11:12,147
FOLKS IN PARTICULAR WHO REALLY

276
00:11:12,147 --> 00:11:20,755
REPRESENT OUR GROUP VERY WELL.

277
00:11:20,755 --> 00:11:22,590
WELL WE ALSO PLAY A BIG ROLE

278
00:11:22,590 --> 00:11:25,193
ACROSS OUR COMMUNITY AND HERE

279
00:11:25,193 --> 00:11:26,661
JUST EXEMPLIFIES 2 OF THE MAJOR

280
00:11:26,661 --> 00:11:28,163
PROFESSIONAL ORGANIZATIONS IN

281
00:11:28,163 --> 00:11:31,433
THE CANCER WORLD, AACR AND ASCO,

282
00:11:31,433 --> 00:11:32,801
A COUPLE THINGS TO COMMENT ABOUT

283
00:11:32,801 --> 00:11:35,003
THE NCI AND THE PARTNERSHIP WITH

284
00:11:35,003 --> 00:11:40,175
THESE AND OTHER ORGANIZATIONS.

285
00:11:40,175 --> 00:11:41,676
FIRST OF ALL IT WAS REALLY

286
00:11:41,676 --> 00:11:44,045
INSPIRING TO GO TO THESE

287
00:11:44,045 --> 00:11:45,180
DIFFERENT MEETING WITH THE

288
00:11:45,180 --> 00:11:47,382
DIFFERENT HAT AND SEE HOW MUCH

289
00:11:47,382 --> 00:11:49,884
NCI PRESENCE AND COLLABORATION

290
00:11:49,884 --> 00:11:51,586
THERE IS IN THESE COMMUNITIES.

291
00:11:51,586 --> 00:11:55,523
WE HAD 1 IN ACR AND ASCO, REAL

292
00:11:55,523 --> 00:11:57,125
ACHIEVEMENT RECOGNITIONS THAT

293
00:11:57,125 --> 00:12:00,328
COME FROM THE INTRAMURAL

294
00:12:00,328 --> 00:12:02,530
PROGRAM, AGAIN STEVE ROSENBERG

295
00:12:02,530 --> 00:12:06,968
RECEIVING THE LIFETIME

296
00:12:06,968 --> 00:12:11,406
ACHIEVEMENT AWARD AT NCR, AND

297
00:12:11,406 --> 00:12:14,376
SATISH GOP A L, ARE YOU HERE

298
00:12:14,376 --> 00:12:17,379
TODAY, MY MESSAGE AT AACR WAS

299
00:12:17,379 --> 00:12:18,346
FOCUSED ON RECOGNIZING THE FACT

300
00:12:18,346 --> 00:12:21,216
THAT WE'RE MOVING INTEREST A NEW

301
00:12:21,216 --> 00:12:26,321
ERA, AN ERA THAT'S DEFINED BY

302
00:12:26,321 --> 00:12:29,257
MORE COLLABORATION, MORE GROUND

303
00:12:29,257 --> 00:12:33,027
UP RECOGNITION OF CROWD SOURCED

304
00:12:33,027 --> 00:12:33,261
IDEAS.

305
00:12:33,261 --> 00:12:34,662
ACKNOWLEDGMENT OF WHAT WE CAN

306
00:12:34,662 --> 00:12:36,398
LEARN FROM COMMUNITIES AND

307
00:12:36,398 --> 00:12:38,333
UTILIZING DIFFERENT KINDINGS OF

308
00:12:38,333 --> 00:12:39,534
RESOURCES THAT BRING PEOPLE

309
00:12:39,534 --> 00:12:41,269
TOGETHER, PARTICULARLY BIG DATA

310
00:12:41,269 --> 00:12:43,138
AND AI.

311
00:12:43,138 --> 00:12:45,106
AT ASCO, I TALKED ABOUT PUTTING

312
00:12:45,106 --> 00:12:47,409
SOME OF THOSE CONCEPTS INTO PLAY

313
00:12:47,409 --> 00:12:50,979
AS WE RYE TO MOVE CLINICAL

314
00:12:50,979 --> 00:12:52,147
TRIALS FURTHER, FASTER, REACHING

315
00:12:52,147 --> 00:12:53,882
COMMUNITIES THAT THEY NEED TO

316
00:12:53,882 --> 00:12:55,617
SERVE, BOTH RESONATED I THINK

317
00:12:55,617 --> 00:12:57,552
VERY WELL AND HAVE BEEN VERY

318
00:12:57,552 --> 00:13:00,989
HELPFUL FOR THINKING ABOUT NEW

319
00:13:00,989 --> 00:13:04,926
AGENDAS THAT WILL BE ADVANCING

320
00:13:04,926 --> 00:13:05,727
FORWARD.

321
00:13:05,727 --> 00:13:08,029
I WANT TO JUST TAKE 1 MINUTE AND

322
00:13:08,029 --> 00:13:09,564
LET YOU KNOW ABOUT SEVERAL

323
00:13:09,564 --> 00:13:10,899
TRANSITIONS THAT ARE HAPPENING

324
00:13:10,899 --> 00:13:11,499
IN OUR LEADERSHIP.

325
00:13:11,499 --> 00:13:12,867
SOME OF THESE ARE PEOPLE YOU MAY

326
00:13:12,867 --> 00:13:14,402
NOT KNOW BUT WHO MAKE THIS

327
00:13:14,402 --> 00:13:17,672
ORGANIZATION RUN AND SO WHAT

328
00:13:17,672 --> 00:13:19,207
THEY HAVE DONE HAS IMPACTED

329
00:13:19,207 --> 00:13:21,376
EVERYTHING IN THE CANCER SPACE.

330
00:13:21,376 --> 00:13:23,578
THESE 3 ARE RETIREMENTS, THEY'RE

331
00:13:23,578 --> 00:13:27,148
HAPPENING OR HAVE HAPPENED IN

332
00:13:27,148 --> 00:13:29,217
OUR OFFICES, DONNA SEGULL OUR

333
00:13:29,217 --> 00:13:29,951
EXECUTIVE OFFICER, TONY

334
00:13:29,951 --> 00:13:32,353
KD--SALLY WA, THE LEADER FOR THE

335
00:13:32,353 --> 00:13:33,455
CENTER FOR BIO-INFORMATICS AND

336
00:13:33,455 --> 00:13:37,625
INFORMATION TECHNOLOGY AND HENRY

337
00:13:37,625 --> 00:13:39,160
CIOLINO HERE UNTIL THE END OF

338
00:13:39,160 --> 00:13:41,029
THE MONTH WITH THE OFFICE OF

339
00:13:41,029 --> 00:13:42,630
CANCER CENTERS, HENRY ARE YOU

340
00:13:42,630 --> 00:13:44,566
HERE TODAY, HE MAY BE IN AND OUT

341
00:13:44,566 --> 00:13:45,667
A BIT LATER.

342
00:13:45,667 --> 00:13:46,968
THESE FOLKS HAVE COLLECTIVELY

343
00:13:46,968 --> 00:13:49,938
OVER A HUNDRED YEARS OF NCI

344
00:13:49,938 --> 00:13:52,607
EXPERIENCE AND SO THIS IS

345
00:13:52,607 --> 00:13:55,643
REPRESENTING A PRETTY MAJOR

346
00:13:55,643 --> 00:13:56,044
TRANSITION.

347
00:13:56,044 --> 00:13:57,445
AND AN OPPORTUNITY, WE HAVE A

348
00:13:57,445 --> 00:14:00,949
NUMBER OF FOLKS FILLING THOSE

349
00:14:00,949 --> 00:14:04,919
BIG SHOES, WE HAVE ACTING AND

350
00:14:04,919 --> 00:14:06,354
INTERIM AMBER LOWRY WHO IS HERE

351
00:14:06,354 --> 00:14:10,859
SACTING IN A ROLE OF EXECUTIVE

352
00:14:10,859 --> 00:14:14,496
OFFICER, JILL BARHHOLD SLOAN,

353
00:14:14,496 --> 00:14:19,434
SHE'S PROBABLY REMOTE AND CRIST

354
00:14:19,434 --> 00:14:21,536
CHRISTOPH, WILL BE WITH

355
00:14:21,536 --> 00:14:22,437
THEACKING CANCER CENTERS.

356
00:14:22,437 --> 00:14:24,973
ANOTHER PERSON IN OUR INTRAMURAL

357
00:14:24,973 --> 00:14:27,175
PROGRAM, TOM AS DELLY HAS LED

358
00:14:27,175 --> 00:14:28,276
OUR CENTER FOR CANCER RESEARCH

359
00:14:28,276 --> 00:14:30,111
FOR MANY YEARS AND HAS DECIDED

360
00:14:30,111 --> 00:14:32,080
TO FOCUS ON HIS RESEARCH FOR A

361
00:14:32,080 --> 00:14:32,247
BIT.

362
00:14:32,247 --> 00:14:34,849
AS YOU CAN SEE THAT'S REQUIRED 3

363
00:14:34,849 --> 00:14:38,520
PEOPLE TO COVER THAT TERRITORY,

364
00:14:38,520 --> 00:14:39,821
SO IT COVERS CLINICAL AND BASIC

365
00:14:39,821 --> 00:14:45,860
SCIENCE AND SO WE HAVE A DUAL

366
00:14:45,860 --> 00:14:50,698
FUNCTION ACTING SPACE WITH GLEN

367
00:14:50,698 --> 00:14:52,000
MERLINO, AND TBLEN IS ALSO

368
00:14:52,000 --> 00:14:54,736
RETIRING AT THE END OF JUNE AND

369
00:14:54,736 --> 00:14:57,272
CAROL WILL TAKE IT FORWARD AS WE

370
00:14:57,272 --> 00:14:58,439
CONDUCT A NATIONWIDE SEARCH.

371
00:14:58,439 --> 00:15:00,208
SO IN TERMS OF THINGS COMING

372
00:15:00,208 --> 00:15:02,010
SOON, WE HAVE BEEN DOING A LOT

373
00:15:02,010 --> 00:15:04,779
OF RECRUITING AND SO WE WILL

374
00:15:04,779 --> 00:15:07,749
HOPEFULLY BE ANNOUNCING SOON IN

375
00:15:07,749 --> 00:15:08,449
COMING MONTHS, EXECUTIVE

376
00:15:08,449 --> 00:15:13,855
OFFICER, WE'VE HAD AN ACTING FOR

377
00:15:13,855 --> 00:15:15,390
SOMETIME AT THE FREDERICK LABS

378
00:15:15,390 --> 00:15:16,891
AND THE DIRECTOR OF SCIENCE

379
00:15:16,891 --> 00:15:19,761
OPERATIONS AND OUR NEW CENTER

380
00:15:19,761 --> 00:15:20,728
FOR EXTERNAL AFFAIRS, THE IDEA

381
00:15:20,728 --> 00:15:23,731
IS TO BRNG A DIRECTOR THAT

382
00:15:23,731 --> 00:15:25,033
BRINGS TOGETHER, COMMUNICATIONS,

383
00:15:25,033 --> 00:15:27,735
OUR LEGISLATIVE BRANCH AND OUR

384
00:15:27,735 --> 00:15:29,270
ADVOCACY SO THAT WE'RE ALL

385
00:15:29,270 --> 00:15:30,638
REALLY COORDINATED VERY WELL, SO

386
00:15:30,638 --> 00:15:31,839
LOOK OUT FOR THAT NEWS.

387
00:15:31,839 --> 00:15:34,175
THIS IS MY BIG ANNOUNCEMENT OF

388
00:15:34,175 --> 00:15:35,577
THE DAY.

389
00:15:35,577 --> 00:15:39,881
SO WE DO HAVE A BIG NEW

390
00:15:39,881 --> 00:15:41,583
LEADERSHIP POSITION TO ANNOUNCE

391
00:15:41,583 --> 00:15:45,553
AND THIS IS DR. WARREN

392
00:15:45,553 --> 00:15:50,291
[INDISCERNIBLE] WHO IS OUR

393
00:15:50,291 --> 00:15:53,261
INAUGURAL DIRECTOR FOR DATA

394
00:15:53,261 --> 00:15:55,363
SCIENCE, SO I SHOULD MAKE YOU

395
00:15:55,363 --> 00:15:55,997
STAND UP.

396
00:15:55,997 --> 00:15:57,865
SO HE HAS A LONG STANDING

397
00:15:57,865 --> 00:16:00,168
HISTORY WITH THE NCI HERE AND

398
00:16:00,168 --> 00:16:02,170
HAS BEEN AN ADVISOR FOR SOMETIME

399
00:16:02,170 --> 00:16:03,771
AND VERY NATURAL FIT TO TAKE ON

400
00:16:03,771 --> 00:16:05,707
THIS ROLE, DATA IS SUCH AN

401
00:16:05,707 --> 00:16:06,975
IMPORTANT PART OF EVERYTHING

402
00:16:06,975 --> 00:16:10,578
THAT WE DO, AND HIS ROLE WILL BE

403
00:16:10,578 --> 00:16:13,047
TO DIRECT THAT CENTER FOR

404
00:16:13,047 --> 00:16:15,583
BIOMEDICAL INFORMATICS AND IT AS

405
00:16:15,583 --> 00:16:18,786
OUR--AS A MAJOR TOOL, BUT ALSO

406
00:16:18,786 --> 00:16:20,088
TO BE COORDINATING OUR EFFORTS

407
00:16:20,088 --> 00:16:22,790
WITH THE NIH AND THEIR STRATEGIC

408
00:16:22,790 --> 00:16:24,659
PLAN FOR DATA SCIENCE AND

409
00:16:24,659 --> 00:16:28,196
DEVELOP AND IMPLEMENT OUR PLAN

410
00:16:28,196 --> 00:16:29,263
AROUND DATA SCIENCE, SO JUST A

411
00:16:29,263 --> 00:16:33,301
LITTLE BIT TO DO SO WE'RE SO

412
00:16:33,301 --> 00:16:34,736
FLAD YOU'RE HERE WARREN.

413
00:16:34,736 --> 00:16:36,371
AND THEN ROUNDING OUT THE TEAM,

414
00:16:36,371 --> 00:16:41,976
AS WE'RE GOING TO TALK A LOT

415
00:16:41,976 --> 00:16:43,945
ABOUT TODAY IS INITIATIVES TO

416
00:16:43,945 --> 00:16:44,679
ENHANCE THE CLINICAL TRIALS

417
00:16:44,679 --> 00:16:47,348
SPACE AND SO WE BROUGHT ON AS A

418
00:16:47,348 --> 00:16:51,786
SENIOR ADVISOR FOR CLENICAL

419
00:16:51,786 --> 00:16:53,621
RESEARCH DR. SHALON BEGGASHING,

420
00:16:53,621 --> 00:16:54,856
WHO HAS EBFOCUSED ONIVATIONS IN

421
00:16:54,856 --> 00:16:56,024
CLINICAL TRIAL DESIGN EMPLOY HE

422
00:16:56,024 --> 00:16:58,192
AND I WROTE A BLOG AND THIS WAS

423
00:16:58,192 --> 00:17:00,495
AN ADVERTISEMENT, THE CANCER

424
00:17:00,495 --> 00:17:02,563
CURRENTS BLOG AND UPDATED

425
00:17:02,563 --> 00:17:03,498
REGULARLY WITH HIGHLIGHTS OF

426
00:17:03,498 --> 00:17:05,633
WHAT'S GOING ON ACROSS THE NCI,

427
00:17:05,633 --> 00:17:08,369
I ENCOURAGE PEOPLE TO FOLLOW IT,

428
00:17:08,369 --> 00:17:09,671
IT'S A PHENOMENAL COMMUNICATION

429
00:17:09,671 --> 00:17:14,542
DEVICE AND WE WROTE ABOUT WHAT

430
00:17:14,542 --> 00:17:15,910
WE'RE INITIATING.

431
00:17:15,910 --> 00:17:17,045
I THINK LEADERSHIP TRANSITIONS

432
00:17:17,045 --> 00:17:18,646
ARE NOT JUST ABOUT THE PEOPLE IN

433
00:17:18,646 --> 00:17:21,749
THE CENTRAL OFFICE BUT HOW WE

434
00:17:21,749 --> 00:17:23,484
REALLY ENGAGE LEADERSHIP ACROSS

435
00:17:23,484 --> 00:17:28,656
THE ENTIRETY OF THE NCI, MANY OF

436
00:17:28,656 --> 00:17:30,425
YOU WERE AT OUR ADVANTAGE HOC

437
00:17:30,425 --> 00:17:31,893
COMMITTEE MEETING LAST NIGHT AND

438
00:17:31,893 --> 00:17:35,797
HEARD ABOUT THE CANCER EQUITY

439
00:17:35,797 --> 00:17:38,800
LEADERS, ACTUALLY A BUNCH OF OUR

440
00:17:38,800 --> 00:17:39,634
CANCER EQUITY LEADERS ARE HERE

441
00:17:39,634 --> 00:17:41,836
AT THE TABLE AND THEY ARE A

442
00:17:41,836 --> 00:17:43,471
TREMENDOUS DPROWP OF ROLL MODELS

443
00:17:43,471 --> 00:17:45,339
AND LEADERS ACROSS THE CANCER

444
00:17:45,339 --> 00:17:47,508
COMMUNITY TO ENABLE US TO REALLY

445
00:17:47,508 --> 00:17:50,311
TAKE ON HOW WE BRING DIVERSITY

446
00:17:50,311 --> 00:17:51,245
TO OUR WORKFORCE, DIVERSITY TO

447
00:17:51,245 --> 00:17:55,550
OUR CLIEN CALIFORNIA TRIALS AND

448
00:17:55,550 --> 00:17:57,985
WHAT WE NEED TO ALL PATIENT

449
00:17:57,985 --> 00:17:58,419
COMMUNITIES.

450
00:17:58,419 --> 00:18:00,188
WE ALSO ENDORSE LOTS OF PEASHT

451
00:18:00,188 --> 00:18:02,657
ACTIVITIES TO TRY TO ENCOURAGE

452
00:18:02,657 --> 00:18:04,058
LEADERSHIP IN SPACES THAT ARE

453
00:18:04,058 --> 00:18:05,326
IMPORTANT FOR THE NCI.

454
00:18:05,326 --> 00:18:06,494
ONE EXAMPLE THAT I'M REAL

455
00:18:06,494 --> 00:18:08,162
LOAMACYY PROUD OF AND IT WILL

456
00:18:08,162 --> 00:18:14,302
HAPPEN NEXT WEEK IS THE BLACK IN

457
00:18:14,302 --> 00:18:15,603
CANCER CONFERENCE, THIS WAS

458
00:18:15,603 --> 00:18:16,404
SPEARHEADED BY FELLOWS WHO FELT

459
00:18:16,404 --> 00:18:18,840
THERE WAS A NEED FOR VOICES FOR

460
00:18:18,840 --> 00:18:19,340
BLACK RESEARCHERS.

461
00:18:19,340 --> 00:18:21,142
ONE OF THEM WAS AT VANDERBILT

462
00:18:21,142 --> 00:18:23,144
AND I GOT TO SEE THIS HAPPEN IN

463
00:18:23,144 --> 00:18:27,348
ACTION AS IT WAS FIRST A #AND

464
00:18:27,348 --> 00:18:29,417
THEN MOVED INTO A MOVEMENT AND

465
00:18:29,417 --> 00:18:30,518
NOW IT'S A CONFERENCE WE'RE

466
00:18:30,518 --> 00:18:37,258
HOSTING HERE WHICH I WILL SAY

467
00:18:37,258 --> 00:18:39,360
INITIALLY NOT SOLE OUT, I THINK

468
00:18:39,360 --> 00:18:41,395
TICKET WERE FREE, IT WAS FULL

469
00:18:41,395 --> 00:18:44,499
DPOA HAD A WAITING LIST, HAD TO

470
00:18:44,499 --> 00:18:45,800
EXPAND IT, AND IT'S REALLY GOING

471
00:18:45,800 --> 00:18:48,169
TO BE A DYNAMIC AND EXCITING

472
00:18:48,169 --> 00:18:51,672
THING, SO LOOKING FORWARD TO

473
00:18:51,672 --> 00:18:54,075
YOINING THEM INCOME WEEK AND THE

474
00:18:54,075 --> 00:18:58,613
LIST IS ABOUT DOING THINGS RIGHT

475
00:18:58,613 --> 00:19:00,915
AND SONIA SPRING FIELD, I KNOW I

476
00:19:00,915 --> 00:19:03,151
SAW YOU AND SO, THERE YOU ARE,

477
00:19:03,151 --> 00:19:09,290
YES, SO SHE'S OUR DIRECTOR OF

478
00:19:09,290 --> 00:19:11,159
CRCHD, THE CANCER RESEARCH AND

479
00:19:11,159 --> 00:19:12,426
HEALTH DISPARITIES, NOW I CAN'T

480
00:19:12,426 --> 00:19:15,897
THINK OF THE ACRONYM, THAT'S WHY

481
00:19:15,897 --> 00:19:16,864
WE'RE CHANGING IT, SO SHE

482
00:19:16,864 --> 00:19:19,600
BROUGHT TO ME A CONCEPT THAT HAD

483
00:19:19,600 --> 00:19:21,936
BEEN BREWING FOR A BIT TO REALLY

484
00:19:21,936 --> 00:19:24,572
FOCUS ON HEALTH EQUITY AND TO

485
00:19:24,572 --> 00:19:26,207
FOCUS ON THE POSITIVE, THE

486
00:19:26,207 --> 00:19:29,811
IMPACTS THAT WE CAN HAVE BY

487
00:19:29,811 --> 00:19:34,315
DOING REAL WORK TO AGAIN REACH

488
00:19:34,315 --> 00:19:35,183
POPULATIONS WELL TO DEVELOP

489
00:19:35,183 --> 00:19:37,218
INVESTIGATORS WELL AND SO IF

490
00:19:37,218 --> 00:19:38,953
THERE'S A NAME CHANGE COMING

491
00:19:38,953 --> 00:19:40,588
SOON AND THAT CENTER WILL NOW BE

492
00:19:40,588 --> 00:19:42,557
CALLED THE CENTER FOR CANCER

493
00:19:42,557 --> 00:19:43,491
HEGHT EQUIT COMPETENT AGAIN FOR

494
00:19:43,491 --> 00:19:45,293
THOSE OF YOU AT THE

495
00:19:45,293 --> 00:19:47,061
SUBCOMMITTEES LAST NIGHT, I

496
00:19:47,061 --> 00:19:48,229
REALLY LOVED--SHE SAYS THIS

497
00:19:48,229 --> 00:19:50,565
ACRONYM AND YOU SAY IT AND IT

498
00:19:50,565 --> 00:20:00,875
MAKES YOU SMILE. 

499
00:20:04,478 --> 00:20:05,213
IT SIZE CCHE.

500
00:20:05,213 --> 00:20:07,682
NGIVE ME A CHANCE TO MOVE UP AND

501
00:20:07,682 --> 00:20:08,249
TALK ABOUT BUDGET.

502
00:20:08,249 --> 00:20:10,551
SO THIS IS JUST TO LEVEL SET AND

503
00:20:10,551 --> 00:20:12,854
LET YOU ALL SEE WHERE WE ARE

504
00:20:12,854 --> 00:20:14,488
WITH BUDGET AND WHERE WE'VE BEEN

505
00:20:14,488 --> 00:20:15,089
WORKING.

506
00:20:15,089 --> 00:20:17,058
SO IN FISCAL YEAR 2023, SO WE

507
00:20:17,058 --> 00:20:18,659
HAVE THE OPPORTUNITY EVERY YEAR

508
00:20:18,659 --> 00:20:20,261
TO PUT FORWARD A PROPOSED BUDGET

509
00:20:20,261 --> 00:20:22,530
FOR THE WORK THAT WE EXPECT TO

510
00:20:22,530 --> 00:20:24,799
DO AND WHAT WE THINK IT WILL

511
00:20:24,799 --> 00:20:25,933
ACTUALLY COST.

512
00:20:25,933 --> 00:20:28,336
OUR PROFESSIONAL BUDGET WAS 7.7

513
00:20:28,336 --> 00:20:31,772
BILL YEN DOLLARS BUT OUR ACTUAL

514
00:20:31,772 --> 00:20:32,573
BUDGET WAS 7.3.

515
00:20:32,573 --> 00:20:35,109
AS YOU KNOW LAST YEAR THERE WAS

516
00:20:35,109 --> 00:20:36,911
THE DEBT CEILING LIMIT AND

517
00:20:36,911 --> 00:20:38,346
ALTHOUGH OUR WORK GOT MORE

518
00:20:38,346 --> 00:20:41,215
EXPENSIVE, THERE ARE MORE THINGS

519
00:20:41,215 --> 00:20:43,417
WE WANT TO DO IN THE DATA SPACE,

520
00:20:43,417 --> 00:20:45,253
IN THE CLINICAL RESEARCH SPACE

521
00:20:45,253 --> 00:20:47,421
AND ACROSS TRAINING AND

522
00:20:47,421 --> 00:20:50,124
EVERYTHING THAT'S IMPORTANT TO

523
00:20:50,124 --> 00:20:52,526
US BUT NOT LUXURIOUSLY.

524
00:20:52,526 --> 00:20:54,762
THIS IS A REALISTIC ESTIMATE OF

525
00:20:54,762 --> 00:20:57,064
WHAT IT WOULD COST TO DO WAWE

526
00:20:57,064 --> 00:20:59,133
DO, AND OUR ESTIMATE WAS ALMOST

527
00:20:59,133 --> 00:21:01,469
10 BILLION DOLLARS AND AS YOU

528
00:21:01,469 --> 00:21:02,870
KNOW WE GOT 7.22.

529
00:21:02,870 --> 00:21:04,038
IT REFLEKS THE FIRST DECREASE

530
00:21:04,038 --> 00:21:11,145
WE'VE HAD IN MANY YEARS WHICH

531
00:21:11,145 --> 00:21:12,880
WAS BOTH THE ASPIRATION OF THE

532
00:21:12,880 --> 00:21:14,315
CURES ACT FUNDING AND INCREASE

533
00:21:14,315 --> 00:21:15,449
OF OUR BASE.

534
00:21:15,449 --> 00:21:16,617
SO CONGRESS RECOGNIZED WHAT IT

535
00:21:16,617 --> 00:21:17,818
WAS THAT WAS HAPPENING AND SO

536
00:21:17,818 --> 00:21:20,388
THERE WAS AN INCREASE TO ENABLE

537
00:21:20,388 --> 00:21:22,256
US TO BE ABLE TO REALLY PRESERVE

538
00:21:22,256 --> 00:21:24,792
THE WORK THAT WE DO.

539
00:21:24,792 --> 00:21:28,462
BUT THE NET DELTO WAS A

540
00:21:28,462 --> 00:21:29,230
96 MILLION-DOLLAR DECREASE AND

541
00:21:29,230 --> 00:21:30,431
WE HAVE A GRAF THAT SHOULD WILL

542
00:21:30,431 --> 00:21:32,066
SHOW THAT IN A MINUTE.

543
00:21:32,066 --> 00:21:33,367
WE KNOW THE DEBT SEALING

544
00:21:33,367 --> 00:21:34,869
CONTINUES FOR ANOTHER YEAR, WE

545
00:21:34,869 --> 00:21:37,071
WILL FIND OUT LATER THIS YEAR

546
00:21:37,071 --> 00:21:38,940
AND MK WILL GIVE THE LEGISLATIVE

547
00:21:38,940 --> 00:21:40,241
REPORT IN A MINUTE, AND WE WILL

548
00:21:40,241 --> 00:21:44,011
BE ABLE TO GET MORE DOWN IN THE

549
00:21:44,011 --> 00:21:44,345
DETAILS.

550
00:21:44,345 --> 00:21:46,347
THE WORK DIDN'T GET LESS

551
00:21:46,347 --> 00:21:47,715
EXPENSIVE, WE'RE NOT DOING LESS

552
00:21:47,715 --> 00:21:50,785
OF IT, SO OUR PROFESSIONAL

553
00:21:50,785 --> 00:21:52,753
BUDGET FOR FISCAL YEAR 25 IS

554
00:21:52,753 --> 00:21:54,121
OVER 11 BILLION DOLLARS.

555
00:21:54,121 --> 00:21:56,791
AS YOU CAN SEE OUR GLAP IS JUST

556
00:21:56,791 --> 00:21:58,859
GETTING BIGGER AND SO WE ARE

557
00:21:58,859 --> 00:22:01,295
SPENDING A LOT OF TIME THINKING

558
00:22:01,295 --> 00:22:01,996
ABOUT EFFICIENCIES, REALLY THINK

559
00:22:01,996 --> 00:22:03,698
BEING WHAT WE CAN DO WITH THE

560
00:22:03,698 --> 00:22:05,399
FUNDING THAT WEB CONNECTED HAVE

561
00:22:05,399 --> 00:22:06,968
BECAUSE WE HAVE A BIG MISSION

562
00:22:06,968 --> 00:22:10,404
AND WE HAVE REAL WORK TO DO TO

563
00:22:10,404 --> 00:22:11,739
END CANCER AS WE KNOW IT.

564
00:22:11,739 --> 00:22:14,208
I WILL SAY TAKEN--THEY THE

565
00:22:14,208 --> 00:22:15,042
WHITE HOUSE IS AWARE THAT YOU

566
00:22:15,042 --> 00:22:18,145
CAN SEE THE PRESIDENT'S GUJET

567
00:22:18,145 --> 00:22:19,981
PROPOSAL FOR FOOTWORK Y25 WAS

568
00:22:19,981 --> 00:22:20,281
FOR 9.28.

569
00:22:20,281 --> 00:22:24,285
WE'RE FOCUS ON THE QUITE MATCHED

570
00:22:24,285 --> 00:22:26,020
BUT ASKED FOR A SIGNIFICANT

571
00:22:26,020 --> 00:22:28,289
INCREASE FOR US AND WE WILL SEE

572
00:22:28,289 --> 00:22:28,823
WHERE WE LAND.

573
00:22:28,823 --> 00:22:32,059
SO WHAT WE DID WITH OUR FY24

574
00:22:32,059 --> 00:22:33,427
BUDGET, I THINK IT'S IMPORTANT

575
00:22:33,427 --> 00:22:35,529
THAT YOU ALL KNOW WHERE THESE

576
00:22:35,529 --> 00:22:37,965
PAY LINES LAST AND HOW THEY TBET

577
00:22:37,965 --> 00:22:39,600
THERE, BECAUSE WE WERE IN A

578
00:22:39,600 --> 00:22:41,335
CONTINUING RESOLUTION FOR A LONG

579
00:22:41,335 --> 00:22:43,404
TIME AND DID NOT KNOW WHAT THE

580
00:22:43,404 --> 00:22:45,006
BUDGET WOULD COME OUT LOOKING

581
00:22:45,006 --> 00:22:46,974
LIKE, WE HAVE TO SET AN INTERIM

582
00:22:46,974 --> 00:22:49,043
PAY LINE BECAUSE WE HAVE TO PAY

583
00:22:49,043 --> 00:22:50,678
SOMEBODY, WE CAN'T WAIT AND HOLD

584
00:22:50,678 --> 00:22:53,447
ALL THE GRANTS UNTIL WE GET A

585
00:22:53,447 --> 00:22:55,316
CONTINUING RESOLUTION, RIGHT,

586
00:22:55,316 --> 00:22:56,717
CRYSTAL, THAT WOULD BE SO

587
00:22:56,717 --> 00:22:56,984
TERRIBLE.

588
00:22:56,984 --> 00:22:58,586
SO WE COME UP WITH AN ESTIMATE

589
00:22:58,586 --> 00:23:00,688
OF WHAT WE THINK WE CAN DO AND

590
00:23:00,688 --> 00:23:07,161
THE ESTIMATE WAS AT 9% FOR RO-1S

591
00:23:07,161 --> 00:23:12,800
WITH A 5% HANDICAP FOR EARLY

592
00:23:12,800 --> 00:23:13,601
STAGE INVESTIGATORS BRINGING

593
00:23:13,601 --> 00:23:16,037
THEM AT 14% AND WE WERE FUNDING

594
00:23:16,037 --> 00:23:18,572
AT 9% FOR R21S.

595
00:23:18,572 --> 00:23:19,774
ONCE WE HADEUR BUDGET WE DID A

596
00:23:19,774 --> 00:23:21,776
LOT OF MATH AND WE WERE ABLE TO

597
00:23:21,776 --> 00:23:24,645
SET THE FINAL PAY LINE AT 10 BUT

598
00:23:24,645 --> 00:23:25,713
RECOGNIZE THAT WE JUST REALLY

599
00:23:25,713 --> 00:23:29,784
HAVE TO SUPPORT OUR EARLY STAGE

600
00:23:29,784 --> 00:23:32,186
INVESTIGATORS AND SO THEY WERE

601
00:23:32,186 --> 00:23:35,222
KEPT AT 17%.

602
00:23:35,222 --> 00:23:36,424
WE ALSO--THEY WERE 17% BECAUSE

603
00:23:36,424 --> 00:23:38,292
LAST YEAR WAS 12 WITH THE DELTA

604
00:23:38,292 --> 00:23:40,194
5 AGAIN, GETTING THEM TO 17, SO

605
00:23:40,194 --> 00:23:43,397
WE DECIDED TO KEEP THEM AT 17%.

606
00:23:43,397 --> 00:23:44,932
WE ALSO WITH A LITTLE BIT OF

607
00:23:44,932 --> 00:23:46,667
WIGGLE ROOM, WE WERE ABLE TO

608
00:23:46,667 --> 00:23:49,170
KEEP CANCER CENTERS WHOLE AND

609
00:23:49,170 --> 00:23:50,971
DIDN'T FURTHER REDUCE THEM

610
00:23:50,971 --> 00:23:54,442
BECAUSE WE FEEL LIKE THAT'S AN

611
00:23:54,442 --> 00:23:55,242
INFRASTRUCTURE THAT SUPPORTS

612
00:23:55,242 --> 00:23:56,911
EARLY STAGE INVESTIGATORS THAT

613
00:23:56,911 --> 00:23:59,814
SUPPORTS OUR CLINICAL RESEARCH

614
00:23:59,814 --> 00:24:02,550
ENTERPRISE AND IS PART OF OW WE

615
00:24:02,550 --> 00:24:04,585
GET INITIATIVES MOVED OUT AND

616
00:24:04,585 --> 00:24:05,286
THE TRAINING BRAVEN WHOLE

617
00:24:05,286 --> 00:24:07,688
OTHERWISE WE WOULD HAVE CUT Ks

618
00:24:07,688 --> 00:24:10,257
AND Ts AND Fs AND THOSE ARE

619
00:24:10,257 --> 00:24:14,929
OUR FUTURE, SO THOSE WERE HELD

620
00:24:14,929 --> 00:24:15,196
FLAT.

621
00:24:15,196 --> 00:24:18,265
SO IN TERMS OF THE PAY LINE

622
00:24:18,265 --> 00:24:20,768
OVERYEARS, THIS GRAPH SHOWS

623
00:24:20,768 --> 00:24:21,469
WHERE THE ESTABLISHED

624
00:24:21,469 --> 00:24:23,070
INVESTIGATOR AND NEW

625
00:24:23,070 --> 00:24:24,138
INVESTIGATORS HAVE BEEN OVERTHE

626
00:24:24,138 --> 00:24:26,340
LAST 10 YEARS, THIS ACTUALLY

627
00:24:26,340 --> 00:24:27,708
MADE ME FEEL SLIGHTLY BETTER

628
00:24:27,708 --> 00:24:29,577
ABOUT THE 10, I WOULD HAVE LOVED

629
00:24:29,577 --> 00:24:30,878
TO MADE THAT NUMBER HIGHER BUT

630
00:24:30,878 --> 00:24:33,180
AS YOU CAN SEE OUR 10 YEAR

631
00:24:33,180 --> 00:24:35,449
AVERAGE IS 10, AND SO FIRST

632
00:24:35,449 --> 00:24:39,286
MESSAGE TO PEOPLE IS THAT 10 IS

633
00:24:39,286 --> 00:24:40,488
PRETTY DARN TIGHT AND WE DO NOT

634
00:24:40,488 --> 00:24:44,158
KNOW WHAT THE BEST 10% GRANT IS.

635
00:24:44,158 --> 00:24:46,427
WE PROBABLY DO SOMETHING GOOD IN

636
00:24:46,427 --> 00:24:49,430
A NUMBER TWICE OR 3 TIMES THAT

637
00:24:49,430 --> 00:24:50,631
BUT THIS IS WHERE IT IS AND THIS

638
00:24:50,631 --> 00:24:53,501
IS WHERE IT HAS BEEN.

639
00:24:53,501 --> 00:24:55,102
BUT THAT'S REALLY NOT FAIR FOR

640
00:24:55,102 --> 00:24:56,737
SOMEBODY JUST STARTING THEIR LAB

641
00:24:56,737 --> 00:24:59,340
WITH THEIR BRAND NEW TECHNICIAN,

642
00:24:59,340 --> 00:25:01,408
WHO THEY'RE ALSO THE BEST POST

643
00:25:01,408 --> 00:25:04,411
DOC IN THE LAB AND WITH THEIR

644
00:25:04,411 --> 00:25:05,813
BRILLIANT NEW IDEA ANDS SO

645
00:25:05,813 --> 00:25:07,214
THAT'S WHY THE EARLY STAGE

646
00:25:07,214 --> 00:25:08,549
INVESTIGATOR, AS YOU CAN SEE

647
00:25:08,549 --> 00:25:10,417
IT'S BEEN AN INITIATIVE NOW FOR

648
00:25:10,417 --> 00:25:12,386
COMING UP ON 10 YORES TO REALLY

649
00:25:12,386 --> 00:25:14,455
SUPPORT THEM MORE, AND SO,

650
00:25:14,455 --> 00:25:16,624
KEEPING THEM AT 17 WAS SOMETHING

651
00:25:16,624 --> 00:25:23,764
THAT WE FELT REALLY STRONGLY

652
00:25:23,764 --> 00:25:24,131
ABOUT.

653
00:25:24,131 --> 00:25:26,467
SO WITH A TIGHT BUDGET, WHAT DO

654
00:25:26,467 --> 00:25:27,635
WE THINK ABOUT, WAARE WE GOING

655
00:25:27,635 --> 00:25:29,303
TO DO, I FIND AUTOHELPFUL TO

656
00:25:29,303 --> 00:25:31,472
THINK ABOUT GOALS AND VALUES

657
00:25:31,472 --> 00:25:37,511
WHEN I HAVE TO MAKE  DECISIONS

658
00:25:37,511 --> 00:25:39,713
WITH THE TEAM, FORTUNATELY WOO

659
00:25:39,713 --> 00:25:40,881
HAVE THE NATIONAL CANCER PLAN

660
00:25:40,881 --> 00:25:42,550
WHICH SETS OUT GOALS, THE

661
00:25:42,550 --> 00:25:44,385
NATIONAL CANCER PLAN WAS

662
00:25:44,385 --> 00:25:45,586
PRESENTED OVER AIER AGO AND JUST

663
00:25:45,586 --> 00:25:48,222
OVER AIER OLD AND PUTS TOGETHER

664
00:25:48,222 --> 00:25:51,992
A ROADMAP FOR WHAT WE NEED TO BE

665
00:25:51,992 --> 00:25:54,328
FOCUSING ON TO MAKE BIG

666
00:25:54,328 --> 00:25:55,563
ADVANCEMENTS FOR CANCER.

667
00:25:55,563 --> 00:25:57,765
THIS NATIONAL CANCER PLAN HAS 4

668
00:25:57,765 --> 00:26:01,168
HEALTH CENTERED GOALS THAT

669
00:26:01,168 --> 00:26:02,903
REALLY ENCOMPASSES PATIENT

670
00:26:02,903 --> 00:26:04,171
EXPERIENCE, PREVENTION, EARLY

671
00:26:04,171 --> 00:26:05,773
DETECTION, DEVELOPMENT OF

672
00:26:05,773 --> 00:26:06,941
EFFECTIVE THERAPEUTICS AND

673
00:26:06,941 --> 00:26:08,542
OPTIMAL PATIENT CARE, THAT WHOLE

674
00:26:08,542 --> 00:26:10,844
EXPERIENCE OF THE PASHT WITH

675
00:26:10,844 --> 00:26:13,714
CANCER BUT THEN EMPOWERS THEM

676
00:26:13,714 --> 00:26:15,783
WITH GOALS THAT ARE MACK

677
00:26:15,783 --> 00:26:17,084
MYSELFING DATA UTILITY AGAINST

678
00:26:17,084 --> 00:26:19,787
THESE DATA AI, THEY COME UP ALL

679
00:26:19,787 --> 00:26:22,423
THE TIME.

680
00:26:22,423 --> 00:26:23,224
ELIMINATING INIQUITIES, WE CAN

681
00:26:23,224 --> 00:26:24,425
DO MORE IF WORE REACHING THE

682
00:26:24,425 --> 00:26:26,060
PATIENT WHO IS REALLY NEED OUR

683
00:26:26,060 --> 00:26:28,262
WORK EMPLOY OPTIMIZING THE

684
00:26:28,262 --> 00:26:29,430
WORKFORCE, THIS GETS BACK TO

685
00:26:29,430 --> 00:26:30,731
SUPPORTING EARLY CAREER

686
00:26:30,731 --> 00:26:32,233
INVESTIGATORS, MAKING SURE WE

687
00:26:32,233 --> 00:26:33,734
HAVE A PIPELINE, INSURING PEOPLE

688
00:26:33,734 --> 00:26:36,503
FIND THIS FIELD EXCITING, IT IS

689
00:26:36,503 --> 00:26:38,872
THE MOST EXCITING FIELD THAT

690
00:26:38,872 --> 00:26:39,940
THERE IS.

691
00:26:39,940 --> 00:26:40,774
AND ENGAGING EVERY PERSON AND

692
00:26:40,774 --> 00:26:43,277
THIS IS WHERE WE CAN MAKE SOME

693
00:26:43,277 --> 00:26:45,079
OF THE THAT IGFEST IMPROVEMENT

694
00:26:45,079 --> 00:26:52,186
IN THOSE HEALTH CENTERED GOALS,

695
00:26:52,186 --> 00:26:53,687
REALLY ENGAGING EVERY 1, AND

696
00:26:53,687 --> 00:26:55,589
GABBING TO THE 60S, BACK TO THE

697
00:26:55,589 --> 00:26:57,524
SECTIONAL ANALYSISS TYPE ERA OF

698
00:26:57,524 --> 00:26:59,493
HOW WE ALL NAVIGATE THE WORLD IS

699
00:26:59,493 --> 00:27:00,327
REALLY BRINGING EVERYBODY INTO

700
00:27:00,327 --> 00:27:03,430
PLAY AND THAT LETS US GET TO OUR

701
00:27:03,430 --> 00:27:05,532
MOON SHOT GOALS, IMPROVED HEALTH

702
00:27:05,532 --> 00:27:07,501
OUTCOMES FOR EVERYONE AND

703
00:27:07,501 --> 00:27:12,273
PRODUCING CANCER MORTALITY BY

704
00:27:12,273 --> 00:27:12,973
50%, BY 2047.

705
00:27:12,973 --> 00:27:16,277
THE VALUES THAT WE USE TO APPLY

706
00:27:16,277 --> 00:27:18,846
TO THESE TALENT DEVELOPMENT,

707
00:27:18,846 --> 00:27:21,315
AGAIN, REALLY FOCUSING ON HOW WE

708
00:27:21,315 --> 00:27:23,317
DO THE BEST WORK, WHO DOES THE

709
00:27:23,317 --> 00:27:25,252
BEST WORK, HOW WE GET YOUNG

710
00:27:25,252 --> 00:27:27,454
PEOPLE IN BUT HOW DO WE DEVELOP

711
00:27:27,454 --> 00:27:29,290
PEOPLE AT MIDCAREER AND HOW WE

712
00:27:29,290 --> 00:27:32,359
DEVELOP PEOPLE TO WORK IN THIS

713
00:27:32,359 --> 00:27:33,727
ERA WHERE DATA CONSCIENCE IS

714
00:27:33,727 --> 00:27:36,263
RIGHT OUT THERE AT THE FOREFRONT

715
00:27:36,263 --> 00:27:39,066
AND THAT'S A BIG FOCUS.

716
00:27:39,066 --> 00:27:40,134
CREATIVITY AND INNOVATION,

717
00:27:40,134 --> 00:27:42,736
THAT'S WHAT DREW US ALL INTO

718
00:27:42,736 --> 00:27:45,572
CANCER, I'M SURE AND THAT IS AN

719
00:27:45,572 --> 00:27:48,542
OPPORTUNITY FOR US TO REALLY

720
00:27:48,542 --> 00:27:50,878
PUSH THE NEEDLE AND HELP TO

721
00:27:50,878 --> 00:27:52,279
ENABLE MORE CREATIVITY AND

722
00:27:52,279 --> 00:27:54,114
INNOVATION IN EVERY SPACE THAT

723
00:27:54,114 --> 00:27:55,416
WE WORK IN, ESPECIALLY WHEN

724
00:27:55,416 --> 00:27:57,584
TIMES ARE TIGHT AND WE HAVE TO

725
00:27:57,584 --> 00:28:01,255
BE CREATIVE AND INNOVATIVE AND

726
00:28:01,255 --> 00:28:01,555
EMPOWERMENT.

727
00:28:01,555 --> 00:28:06,193
THIS AGAIN GETS  GETS BACK TO EG

728
00:28:06,193 --> 00:28:06,827
EVERY PERSON.

729
00:28:06,827 --> 00:28:08,062
MAKING SURE THOSE VOICES ARE

730
00:28:08,062 --> 00:28:08,729
BEING HEARD.

731
00:28:08,729 --> 00:28:13,701
WHEN WE TALKED AT ASCO ABOUT

732
00:28:13,701 --> 00:28:14,768
REINVENTING CLINICAL TRIALS OR

733
00:28:14,768 --> 00:28:17,204
THINKING ABOUT HOW WE COULD GO

734
00:28:17,204 --> 00:28:18,839
FURTHER, FASTER, WE HAD CALLED

735
00:28:18,839 --> 00:28:20,674
TO ACTION, ASKING THE COMMUNITY

736
00:28:20,674 --> 00:28:22,976
WHAT SHOULD WE DO, LIKE WHAT ARE

737
00:28:22,976 --> 00:28:24,278
YOU SEEING THAT WE ARE MISSING

738
00:28:24,278 --> 00:28:25,679
THAT WE CAN DO FASTER.

739
00:28:25,679 --> 00:28:28,082
WE WILL BE COLLECTING THAT DATA

740
00:28:28,082 --> 00:28:30,551
BUT EVEN THE NAP SHOTS THAT I'VE

741
00:28:30,551 --> 00:28:31,251
SEEN ARE BRILLIANT.

742
00:28:31,251 --> 00:28:32,386
I MEAN PEOPLE IN THE COMMUNITIES

743
00:28:32,386 --> 00:28:34,355
KNOW WHAT THEY NEED AND SO

744
00:28:34,355 --> 00:28:36,190
EMPOWERING THEM TO BE ABLE TO

745
00:28:36,190 --> 00:28:38,192
SPEAK UP IS A BIG PART OF HOW WE

746
00:28:38,192 --> 00:28:40,027
THINK ABOUT THIS IN A TIGHT

747
00:28:40,027 --> 00:28:42,329
BUDGET TIME AND THEN FISCAL

748
00:28:42,329 --> 00:28:42,696
RESPONSIBILITY.

749
00:28:42,696 --> 00:28:44,998
I MEAN THIS IS JUST A REALITY OF

750
00:28:44,998 --> 00:28:50,671
WHERE WE ARE AND HOW WE HAVE TO

751
00:28:50,671 --> 00:28:51,805
MAKE GOOD DECISIONS.

752
00:28:51,805 --> 00:28:53,841
SO LET'S GO INTO MORE FUN WHICH

753
00:28:53,841 --> 00:28:59,246
IS RESEARCH AND PROGRAM

754
00:28:59,246 --> 00:28:59,546
HIGHLIGHTS.

755
00:28:59,546 --> 00:29:01,248
SORRY I DIDN'T USE MY SCRIPT FOR

756
00:29:01,248 --> 00:29:03,150
A REALLY LONG TIME, I HAVE TO

757
00:29:03,150 --> 00:29:03,917
CATCH BACK UP.

758
00:29:03,917 --> 00:29:10,657
OKAY, SO WE WILL TALK ABOUT

759
00:29:10,657 --> 00:29:13,060
SEVERAL EXCITING ADVANCES PARTLY

760
00:29:13,060 --> 00:29:14,928
IN THE GENETICS PROGRAM AND ALSO

761
00:29:14,928 --> 00:29:16,230
IN THE CLINICAL RESEARCH ARENA

762
00:29:16,230 --> 00:29:17,564
BUT THERE ARE ADVANCES ACROSS

763
00:29:17,564 --> 00:29:19,867
ALL THE SPACES THAT WE WORK IN,

764
00:29:19,867 --> 00:29:23,871
THIS IS JUST AS OF TRYING TO

765
00:29:23,871 --> 00:29:25,606
CAPTURE REALLY EXCITING THINGS

766
00:29:25,606 --> 00:29:29,042
IN THE BASIC SCIENCE FIELD, IN

767
00:29:29,042 --> 00:29:32,146
THE AI AND DATA SCIENCE WORK IN

768
00:29:32,146 --> 00:29:33,514
TRANSLATIONAL AND IN CLINICAL

769
00:29:33,514 --> 00:29:36,383
RESEARCH, ALL OF WHICH AGAIN

770
00:29:36,383 --> 00:29:38,552
BACK TO NATIONAL CANCER PLAN IS

771
00:29:38,552 --> 00:29:39,386
NECESSARY AND REALLY IMPORTANT

772
00:29:39,386 --> 00:29:45,559
THAT WE'RE ABLE TO MOVE IT

773
00:29:45,559 --> 00:29:45,793
FORWARD.

774
00:29:45,793 --> 00:29:47,294
OKAY, THE THEME TODAY IS GOING

775
00:29:47,294 --> 00:29:48,829
TO FOCUS MORE ON CLENICAL

776
00:29:48,829 --> 00:29:51,198
RESEARCH AND TRANSFORMING

777
00:29:51,198 --> 00:29:52,699
CLENICAL RESEARCH THAN ON OTHER

778
00:29:52,699 --> 00:29:52,900
PARTS.

779
00:29:52,900 --> 00:29:54,735
AS I SAID THERE'S A LOT OF TO

780
00:29:54,735 --> 00:29:56,470
COVER, SO THAT'S GOING TO BE MY

781
00:29:56,470 --> 00:29:59,373
FOCUS FOR THE HIGHLIGHTS TODAY.

782
00:29:59,373 --> 00:30:01,041
THINGS THAT WE'RE DOING NOW, AND

783
00:30:01,041 --> 00:30:02,976
OF COURSE, THERE'S MORE IN OUR

784
00:30:02,976 --> 00:30:06,013
BACK POCKETS AND MORE COMING,

785
00:30:06,013 --> 00:30:07,281
MORE DECENTRALIZED CLINICAL

786
00:30:07,281 --> 00:30:10,350
TRIAL DESIGN AND ENABLING THE

787
00:30:10,350 --> 00:30:12,186
CLINICAL TRIALS TO GET OUT INTO

788
00:30:12,186 --> 00:30:15,155
THE COMMUNITIES WHERE WE NEED

789
00:30:15,155 --> 00:30:16,723
THEM, WE LEARNED SO MANY THINGS

790
00:30:16,723 --> 00:30:18,425
FROM THE PANDEMIC AS AN EASY

791
00:30:18,425 --> 00:30:20,294
EXAMPLE TO THINK ABOUT WHERE WE

792
00:30:20,294 --> 00:30:20,861
CAN MOVE THINGS.

793
00:30:20,861 --> 00:30:22,563
ONE PIECE YOU WILL HEAR A LOT

794
00:30:22,563 --> 00:30:25,732
MORE TODAY ABOUT IS THE VIRTUAL

795
00:30:25,732 --> 00:30:27,534
CLINICAL TRIALS OFFICE, AND

796
00:30:27,534 --> 00:30:30,938
OPPORTUNITY TO REALLY TAKE THE

797
00:30:30,938 --> 00:30:31,738
VIRTUAL EXPERIENCE OF

798
00:30:31,738 --> 00:30:33,173
INTERACTION INTO THE CLINICAL

799
00:30:33,173 --> 00:30:34,641
WORK SPACE AND INTO THE CLINICAL

800
00:30:34,641 --> 00:30:37,511
RESEARCH SPACE AND A LOT TO

801
00:30:37,511 --> 00:30:42,282
LEARN IN THAT EXPERIMENT.

802
00:30:42,282 --> 00:30:43,484
THE CLINICAL TRIALS INNOVATION

803
00:30:43,484 --> 00:30:45,953
UNIT IS A SPACE WHERE WE'RE

804
00:30:45,953 --> 00:30:47,621
BRINGING TOGETHER, THE NCTN, THE

805
00:30:47,621 --> 00:30:50,090
NCI AND THE FDA TO REALLY WORK

806
00:30:50,090 --> 00:30:51,391
CLINICAL TRIALS, AND WORK ON HOW

807
00:30:51,391 --> 00:30:53,560
WE MOVE THEM THROUGH FASTER.

808
00:30:53,560 --> 00:30:56,563
THE FROWP LAST NIGHT HEARD ABOUT

809
00:30:56,563 --> 00:30:58,599
THE PRAGMATIC LUNG TRIAL WHICH

810
00:30:58,599 --> 00:31:00,267
IS A PRAGMATIC TRIAL THAT WAS

811
00:31:00,267 --> 00:31:03,337
ACCELERATED OR BOOSTED BY THE

812
00:31:03,337 --> 00:31:05,339
CTIU AND NOW THE NEXT MOVEMENT

813
00:31:05,339 --> 00:31:07,541
OF THE CTIU IS TO TAKE ON

814
00:31:07,541 --> 00:31:09,710
DIFFERENT PARTS OF HOW WE

815
00:31:09,710 --> 00:31:10,644
ACCELERATE CLINICAL TRIAL ANDS

816
00:31:10,644 --> 00:31:14,281
HOW WE MOVE THINGS SO THAT THE

817
00:31:14,281 --> 00:31:15,949
TIME TO CONCEPT TO GETTING

818
00:31:15,949 --> 00:31:17,451
THINGS IN THE HANDS OF PATIENT

819
00:31:17,451 --> 00:31:18,285
SYSTEM SHORTER BECAUSE WE'RE

820
00:31:18,285 --> 00:31:21,121
LOOKING AT A WORLD THAT MOVES

821
00:31:21,121 --> 00:31:23,290
FASTER AND SO OUR CLINICAL

822
00:31:23,290 --> 00:31:25,158
TRIALS SPACE HAS TO KEEP UP, 1

823
00:31:25,158 --> 00:31:27,327
OF THE THINGS I'VE BEEN MOST

824
00:31:27,327 --> 00:31:30,330
INSPIRED BY IN THESE LAST COUPLE

825
00:31:30,330 --> 00:31:32,866
MONTHS IS INCREDIBLE ENGAGEMENT

826
00:31:32,866 --> 00:31:35,936
OF THE FDA, THEY ARE REALLY

827
00:31:35,936 --> 00:31:37,804
COMMITTED TO MAKING IT A

828
00:31:37,804 --> 00:31:46,380
REALITY, AND WE CAN BE A PART OF

829
00:31:46,380 --> 00:31:46,813
MOVING THAT FORWARD.

830
00:31:46,813 --> 00:31:49,550
I JUST WANT TO GIVE A SHOUT OUT

831
00:31:49,550 --> 00:31:51,752
TO THE MATCH AND SO IT WAS AN

832
00:31:51,752 --> 00:31:54,621
EXAMPLE OF HOW IT COULD ACCRUE

833
00:31:54,621 --> 00:31:56,390
RAPIDLY WITH LOTS OF QUESTIONS

834
00:31:56,390 --> 00:31:59,927
IN A WELL DESIGNED MANNER.

835
00:31:59,927 --> 00:32:03,897
KUDOS TO JIM DOROSHOW, WHO HAS

836
00:32:03,897 --> 00:32:05,832
LED THESE INITIATIVES AND NOW

837
00:32:05,832 --> 00:32:07,935
WITH MILE A MATCH WHICH JUST

838
00:32:07,935 --> 00:32:11,572
OPENED AND COMBO MATCH WHICH IS

839
00:32:11,572 --> 00:32:16,076
ALMOST--I CAN'T REMEMBER WHERE

840
00:32:16,076 --> 00:32:17,344
THAT 1 IS--OH, SOON.

841
00:32:17,344 --> 00:32:20,113
BUT THESE ARE TRIALS THAT WILL

842
00:32:20,113 --> 00:32:21,748
REALLY TRANSFORM THE WAY WE

843
00:32:21,748 --> 00:32:25,052
INTERACT WITH PATIENTS AND

844
00:32:25,052 --> 00:32:26,320
ENGEAJ WITH THE INTERACTIONS

845
00:32:26,320 --> 00:32:28,155
BETWEEN WHERE OUR PATIENT IS AND

846
00:32:28,155 --> 00:32:30,023
THEIR DISEASE PROCESS AND THEIR

847
00:32:30,023 --> 00:32:34,561
THERAPY AND JUST MORE BROADLY

848
00:32:34,561 --> 00:32:35,829
INCORPORATING ACROSS THE

849
00:32:35,829 --> 00:32:37,531
CLINICAL TRIAL BASE.

850
00:32:37,531 --> 00:32:39,032
SOME CLINICAL EFFORTS TO

851
00:32:39,032 --> 00:32:41,635
COLLABORATE AND TRANSFORM IN THE

852
00:32:41,635 --> 00:32:42,803
CLINICAL RESEARCH SPACE, WE ALSO

853
00:32:42,803 --> 00:32:45,305
HEARD LAST NIGHT ABOUT THE

854
00:32:45,305 --> 00:32:47,407
VANGUARD STUDY LOOKING AT

855
00:32:47,407 --> 00:32:48,375
MULTICANCKER DETECTION TESTS TO

856
00:32:48,375 --> 00:32:50,210
WORK IN THE PRIMARY CARE SPACE

857
00:32:50,210 --> 00:32:54,114
AND TO REALLY KNOW HOW TESTS OF

858
00:32:54,114 --> 00:32:55,949
MULTIPLE CANCERS CAN BE USED

859
00:32:55,949 --> 00:32:57,017
EFFECTIVELY, HOW DO WE

860
00:32:57,017 --> 00:32:59,419
COMMUNICATE ABOUT THAT, WHAT IS

861
00:32:59,419 --> 00:33:00,721
THE INFRASTRUCTURE BEHIND IT TO

862
00:33:00,721 --> 00:33:01,989
MANAGE THOSE PATIENTS AND SO

863
00:33:01,989 --> 00:33:03,757
MANY QUESTIONS WE WILL LEARN BY

864
00:33:03,757 --> 00:33:05,826
TAKING ON A QUESTION LIKE THAT.

865
00:33:05,826 --> 00:33:11,398
THE  SHIP TRIAL IS ANOTHER TRIA,

866
00:33:11,398 --> 00:33:12,799
SELF-COLLECTION FOR HEART ATTACK

867
00:33:12,799 --> 00:33:15,335
PV TESTING FOR ENGAGING EVERY

868
00:33:15,335 --> 00:33:16,737
PERSON, PUTTING IN THE TESTING

869
00:33:16,737 --> 00:33:18,071
INTO THE HANDS OF PATIENTS TO

870
00:33:18,071 --> 00:33:19,906
KNOW THEIR OWN RISK FOR CERVICAL

871
00:33:19,906 --> 00:33:22,476
CANCER BASED ON THEIR HPV STATUS

872
00:33:22,476 --> 00:33:24,544
AND SO REALLY A LOT OF BOLD

873
00:33:24,544 --> 00:33:27,180
THINKING IS GOING INTO THAT

874
00:33:27,180 --> 00:33:29,049
STUDY AND THEN FINALLY, I JUST

875
00:33:29,049 --> 00:33:31,585
POINT OUT, THAT WE'RE NOT DOING

876
00:33:31,585 --> 00:33:34,554
THIS ALONE, THIS IS--ANSWERS A

877
00:33:34,554 --> 00:33:36,590
GLOBAL PROBLEM AND THE ISSUES

878
00:33:36,590 --> 00:33:40,794
ARE NOT UNIQUE AND WE CAN DO

879
00:33:40,794 --> 00:33:42,062
MORE TOGETHER IN THE

880
00:33:42,062 --> 00:33:42,796
INTERNATIONAL ASSOCIATION FOR

881
00:33:42,796 --> 00:33:45,165
RESEARCH ON CANCER AND THE G7.

882
00:33:45,165 --> 00:33:48,502
BIG FOCUS IS ON PREVENTION, BUT

883
00:33:48,502 --> 00:33:50,370
RARE TUMORS, YOU THINK ABOUT AS

884
00:33:50,370 --> 00:33:53,807
WE LEARN ABOUT MORE AND MORE

885
00:33:53,807 --> 00:33:55,208
COMPLEX SUBDIVISIONS AND ULTRA

886
00:33:55,208 --> 00:33:56,610
RARE TUMOR TYPES, THERE'S NO

887
00:33:56,610 --> 00:33:58,478
CENTER IN THE UNITED STATES THAT

888
00:33:58,478 --> 00:33:59,980
CAN REALLY MANAGE, IN THE WHOLE

889
00:33:59,980 --> 00:34:01,682
UNITED STATES EVEN COVER A

890
00:34:01,682 --> 00:34:03,750
DISEASE THAT MIGHT ONLY HAVE 30

891
00:34:03,750 --> 00:34:05,185
OR 40 DIAGNOSIS IN A YEAR, WE

892
00:34:05,185 --> 00:34:07,154
REALLY HAVE TO TAKE THIS GLOBAL

893
00:34:07,154 --> 00:34:09,322
AND WORK TOGETHER AND SO THOSE

894
00:34:09,322 --> 00:34:10,991
OPPORTUNITIES ARE REALLY WHERE

895
00:34:10,991 --> 00:34:16,463
WE CAN MAKE A BIG DIFFERENCE.

896
00:34:16,463 --> 00:34:19,766
ON THE THEME OF BRINGING CANCER

897
00:34:19,766 --> 00:34:20,701
RESEARCH INTO THE COMMUNITY,

898
00:34:20,701 --> 00:34:24,304
THIS WAS SOMETHING THAT CAME UP

899
00:34:24,304 --> 00:34:26,073
MANY TIMES IN MY EARLY WEEKS IN

900
00:34:26,073 --> 00:34:28,275
THIS JOB AND REALIZING THAT

901
00:34:28,275 --> 00:34:29,443
THERE ARE ASSETS IN THE

902
00:34:29,443 --> 00:34:32,212
COMMUNITY THAT WE ARE PROBABLY

903
00:34:32,212 --> 00:34:33,246
SILOED FROM AND THERE ARE IDEAS

904
00:34:33,246 --> 00:34:35,549
THAT WE NEED TO BE ABLE TO BRING

905
00:34:35,549 --> 00:34:38,985
FORWARD AND THERE'S A LOT TO

906
00:34:38,985 --> 00:34:40,921
REALLY TACKLE TO ACHIEVE A GOAL

907
00:34:40,921 --> 00:34:42,089
WHERE EVERYONE GETS THE CARE

908
00:34:42,089 --> 00:34:45,092
THAT THEY NEED AND EVERYONE HAS

909
00:34:45,092 --> 00:34:46,093
ACCESS TO A CLINICAL TRIAL WHO

910
00:34:46,093 --> 00:34:48,195
WOULD LIKE TO HAVE 1.

911
00:34:48,195 --> 00:34:50,964
AND SO WHAT WE DECIDED TO DO WAS

912
00:34:50,964 --> 00:34:51,898
GET AN ADHOC WORKING GROUP

913
00:34:51,898 --> 00:34:54,201
TOGETHER AND SO I'M REALLY

914
00:34:54,201 --> 00:34:55,469
EXCITED ABOUT THIS GROUP.

915
00:34:55,469 --> 00:34:56,970
SO THIS GROUP JUST LAUNCHED

916
00:34:56,970 --> 00:35:00,974
ABOUT A MONTH AGO, AND IS TAKING

917
00:35:00,974 --> 00:35:02,709
ON THESE QUESTIONS AND WILL BE

918
00:35:02,709 --> 00:35:05,979
BRINGING BACK AND WE'LL HAVE THE

919
00:35:05,979 --> 00:35:07,714
REPORT HERE ON WHAT THEIR

920
00:35:07,714 --> 00:35:10,250
FINDINGS ARE, WHAT IS THE

921
00:35:10,250 --> 00:35:11,284
SHORT-TERM MEDIUM TERM,

922
00:35:11,284 --> 00:35:13,253
LONG-TERM THINGS THAT WE AT THE

923
00:35:13,253 --> 00:35:15,122
NKRRK I AND IN OTHER COMPONENTS

924
00:35:15,122 --> 00:35:17,758
OF THE GOVERNMENT CAN DO TO

925
00:35:17,758 --> 00:35:23,063
REALLY ACHIEVE THAT OUTCOME.

926
00:35:23,063 --> 00:35:30,837
I HAVE TO GIVE KUDOS TO RAY

927
00:35:30,837 --> 00:35:33,340
[INDISCERNIBLE], SO RAY IS A CO

928
00:35:33,340 --> 00:35:34,508
CHAIR, BUT WE HAVE OTHER MEMBERS

929
00:35:34,508 --> 00:35:38,812
OF THE COMMITTEE WHO ARE HERE

930
00:35:38,812 --> 00:35:41,014
INDICATED IN BLUE, BILL AT THE

931
00:35:41,014 --> 00:35:42,349
AMERICAN CANCER SOCIETY, THIS IS

932
00:35:42,349 --> 00:35:43,750
NOT AN NCI, WE WILL SOLVE THE

933
00:35:43,750 --> 00:35:46,353
PROBLEM, WE WILL REACH OUT TO

934
00:35:46,353 --> 00:35:47,754
THE COMMUNITY.

935
00:35:47,754 --> 00:35:51,091
OUR EXECUTIVE SECRETARY IS

936
00:35:51,091 --> 00:35:52,826
ANDREA DENICOFOOTWORK FOOTWORK,

937
00:35:52,826 --> 00:35:54,027
SHE'S NCI BUT SHE'S BEEN A

938
00:35:54,027 --> 00:35:56,229
LEADER IN HOW WE BRING CLAINICAL

939
00:35:56,229 --> 00:35:57,864
TRIALS TO THE VA IN PART MERSHIP

940
00:35:57,864 --> 00:36:00,167
AND WE HAVE PARTNERS HERE ACROSS

941
00:36:00,167 --> 00:36:02,235
THE FEDERAL GOVERNMENT AND IN

942
00:36:02,235 --> 00:36:09,209
OTHER SPACES AS WELL IN PRIVATE

943
00:36:09,209 --> 00:36:10,343
SPACES, TOO.

944
00:36:10,343 --> 00:36:11,411
AND THEN FINALLY I'M VERY

945
00:36:11,411 --> 00:36:13,013
COMMITTED TO HEARING FROM THE

946
00:36:13,013 --> 00:36:13,280
COMMUNITY.

947
00:36:13,280 --> 00:36:14,447
SO I ALREADY MENTIONED WE'VE

948
00:36:14,447 --> 00:36:15,682
DONE A COUPLE OF OPEN CALLS TO

949
00:36:15,682 --> 00:36:17,250
SEE MEN AND WOMEN PEOPLE HAVE TO

950
00:36:17,250 --> 00:36:18,985
SAY, THAT WAS 1 OF THE FIRST

951
00:36:18,985 --> 00:36:20,854
THINGS I DID, GOT REALLY

952
00:36:20,854 --> 00:36:23,123
INTERESTING FEEDBACK, AND MORE

953
00:36:23,123 --> 00:36:25,392
RECENTLY, HOW CAN WE REIMAGINE

954
00:36:25,392 --> 00:36:28,361
CLINICAL RESEARCH TO ACCELERATE

955
00:36:28,361 --> 00:36:29,729
PROGRESS WITH PEOPLE WITH

956
00:36:29,729 --> 00:36:30,096
CANCER.

957
00:36:30,096 --> 00:36:31,498
THIS IS JUST AN EXAMPLE OF 1

958
00:36:31,498 --> 00:36:33,400
RESPONSE TO MANY THAT GIVES US

959
00:36:33,400 --> 00:36:35,569
SOME REALLY GOOD FEEDBACK,

960
00:36:35,569 --> 00:36:40,507
HONEST, SOME OF IT VERY CRITICAL

961
00:36:40,507 --> 00:36:41,808
WHEN DO WE PUBLISH THE THINGS

962
00:36:41,808 --> 00:36:43,343
THAT DIDN'T WORK, HOW DO WE GET

963
00:36:43,343 --> 00:36:45,645
THE WORD OUT THERE SO PEOPLE

964
00:36:45,645 --> 00:36:48,215
DON'T TRY TO REINVENT THE WHEEL,

965
00:36:48,215 --> 00:36:50,150
RESOURCES ARE LIMITED AND

966
00:36:50,150 --> 00:36:51,084
PEASHTS DON'T WANT TO WAIT FOR

967
00:36:51,084 --> 00:36:51,985
THAT AND WEB CONNECTED HAVE TO

968
00:36:51,985 --> 00:36:54,287
BE ABLE TO WORK TOGETHER, I'VE

969
00:36:54,287 --> 00:36:55,789
BEEN WORKING WITH TRAINEE GROUPS

970
00:36:55,789 --> 00:36:57,791
AND ADVOCATES AND WHEN I VISIT

971
00:36:57,791 --> 00:36:59,860
PLACES, I'M ASKING TO MEET WITH

972
00:36:59,860 --> 00:37:03,263
TRAINEES AND I'M ASKING TO SPEND

973
00:37:03,263 --> 00:37:04,598
TIME AT NCORP SITES REALLY

974
00:37:04,598 --> 00:37:09,035
SEEING WHAT THE WORK IS THAT

975
00:37:09,035 --> 00:37:10,103
WE'RE DOING EVERYWHERE, AND IN

976
00:37:10,103 --> 00:37:12,105
TERMS OF WHERE DO WE PUT OUR

977
00:37:12,105 --> 00:37:13,373
PRIORITIES, 1 OF THE THINGS THAT

978
00:37:13,373 --> 00:37:15,041
WE'RE DOING THAT'S NEW THAT I'M

979
00:37:15,041 --> 00:37:17,244
REALLY EXCITED ABOUT IS HAVING A

980
00:37:17,244 --> 00:37:18,111
NEW ANNUAL SCIENTIFIC RETREAT,

981
00:37:18,111 --> 00:37:21,081
SO THIS WILL BE HELD IN JULY, WE

982
00:37:21,081 --> 00:37:23,083
ARE IN THE FINAL DAYS OF GETTING

983
00:37:23,083 --> 00:37:24,851
THIS PLANNED UP, SO OUR

984
00:37:24,851 --> 00:37:27,053
LEADERSHIP WILL BE GETTING

985
00:37:27,053 --> 00:37:29,356
TOGETHER, LOOKING AT WITH GROUPS

986
00:37:29,356 --> 00:37:31,858
THAT HAVE DATA SOURCES TO SAY

987
00:37:31,858 --> 00:37:33,593
WHERE ARE THE BIGGEST GAPS,

988
00:37:33,593 --> 00:37:35,462
WHERE CAN WE HAVE A BIG IMPACT,

989
00:37:35,462 --> 00:37:37,397
WHAT IS IT THAT WE'RE LOOKING TO

990
00:37:37,397 --> 00:37:39,332
DO, I MAKE A POINT THIS IS NOT

991
00:37:39,332 --> 00:37:41,101
JUST AN NCI, WHAT WE THINK ABOUT

992
00:37:41,101 --> 00:37:41,968
YOU WE'RE ASKING FOR COMMUNITY

993
00:37:41,968 --> 00:37:43,203
MEMBERS TO BE ABLE TO I DON'T

994
00:37:43,203 --> 00:37:45,205
KNOW US OR BSA CHAIRS ARE

995
00:37:45,205 --> 00:37:46,640
INVITED TO JOIN IN OUR GROUP

996
00:37:46,640 --> 00:37:52,512
WORKING GROUPS ARE INVITING

997
00:37:52,512 --> 00:37:53,079
OTHERS AS WELL.

998
00:37:53,079 --> 00:37:55,849
SO WE WILL PUBLISH THE OUTPUT OF

999
00:37:55,849 --> 00:37:58,618
THIS AND WE WILL GUIDE, I AM

1000
00:37:58,618 --> 00:38:00,220
SURE IT WILL SHOW UP HERE THE

1001
00:38:00,220 --> 00:38:03,123
NEXT TIME I TALK ON THIS PODIUM,

1002
00:38:03,123 --> 00:38:05,191
AND DEPENDING ON HOW THIS IS

1003
00:38:05,191 --> 00:38:07,494
SCHEDULED AND ALSO WHERE WE PUT

1004
00:38:07,494 --> 00:38:10,297
OUR EMPHASIS, WHEN WE'RE WRITING

1005
00:38:10,297 --> 00:38:20,774
THINGS LIKE RFAs, AND SO I'M

1006
00:38:23,677 --> 00:38:25,245
HOPING YOU SEE BSAs AND THEY

1007
00:38:25,245 --> 00:38:26,646
SHOULD REVIEW THEM AND FEEL

1008
00:38:26,646 --> 00:38:28,181
REFRESHED AND FEEL LIKE THERE'S

1009
00:38:28,181 --> 00:38:29,716
SOMETHING WE NEED TO DO TODAY.

1010
00:38:29,716 --> 00:38:30,583
SO THAT'S THE GOAL.

1011
00:38:30,583 --> 00:38:35,221
SO WHAT I NEED FROM YOU I NEED

1012
00:38:35,221 --> 00:38:37,190
TO HEAR AND THAT CAN BE HEAR OR

1013
00:38:37,190 --> 00:38:38,491
LATER WHEN THE MOOD STRIKES

1014
00:38:38,491 --> 00:38:41,094
WHERE YOU WOULD PRIORITIZE

1015
00:38:41,094 --> 00:38:42,162
INNOVATION BECAUSE STAY THE

1016
00:38:42,162 --> 00:38:43,763
THEME WAS CLINICAL RESEARCH, IN

1017
00:38:43,763 --> 00:38:45,065
THE CLINICAL RESEARCH SPACE OF

1018
00:38:45,065 --> 00:38:47,567
COURSE I WILL TAKE ALL.

1019
00:38:47,567 --> 00:38:49,669
WITH REGARD TO FUNDING PLANs

1020
00:38:49,669 --> 00:38:51,404
BECAUSE WE WILL TALK ABOUT OUR

1021
00:38:51,404 --> 00:38:53,707
PHASE TODAY IN PRs, I WANT TO

1022
00:38:53,707 --> 00:38:56,176
MAKE SURE YOU KNOW YOUR INPUT

1023
00:38:56,176 --> 00:38:57,243
ARE INCREDIBLE LOAMACYY VALUABLE

1024
00:38:57,243 --> 00:38:58,745
AND THAT YOUR COMMENTS HELP US

1025
00:38:58,745 --> 00:39:00,580
LEVEL SET AND INSURE WE ARE

1026
00:39:00,580 --> 00:39:02,549
REALLY AT AING OUT IN FRONT.

1027
00:39:02,549 --> 00:39:03,984
I WILL ALSO SAY WE HAVE PUT A

1028
00:39:03,984 --> 00:39:09,789
LOT OF WORK INTO OUR INTERNAL

1029
00:39:09,789 --> 00:39:11,324
VETTING PROCESS, TO LOOK AT

1030
00:39:11,324 --> 00:39:12,492
PRs AND THINK ABOUT WHETHER

1031
00:39:12,492 --> 00:39:16,329
THEY ARE READY TO HAVE LIVED

1032
00:39:16,329 --> 00:39:19,866
THEIR LIFE, AND SUN SET OR IF

1033
00:39:19,866 --> 00:39:21,401
THEY ARE REALLY STILL PUSHING

1034
00:39:21,401 --> 00:39:28,675
AND THAT THEY ARE NECESSARY TO

1035
00:39:28,675 --> 00:39:28,908
KEEP.

1036
00:39:28,908 --> 00:39:34,981
SO THAT'S BEEN A TOPIC OF

1037
00:39:34,981 --> 00:39:37,584
PEOPLE, AND SO WITH YOUR

1038
00:39:37,584 --> 00:39:39,219
SUGGESTIONS HOW WE MOVE FORWARD.

1039
00:39:39,219 --> 00:39:43,056
SO I HAVE TO END WITH THERE IS

1040
00:39:43,056 --> 00:39:46,026
SO MUCH TO BE OFTMYSTIC ABOUT, I

1041
00:39:46,026 --> 00:39:49,496
GET A LOT OF ABOUT IT'S SO SAD

1042
00:39:49,496 --> 00:39:51,097
ABOUT THE BUDGET, AND IT IS A

1043
00:39:51,097 --> 00:39:52,732
TOUGH BUDGET REALITY, WE KNOW

1044
00:39:52,732 --> 00:39:54,100
NEXT YEAR'S LIKELY TO BE TOUGH

1045
00:39:54,100 --> 00:39:56,269
AS SLOW BUT WE CAN'T SLOW DOWN

1046
00:39:56,269 --> 00:39:59,172
AND THERE'S SO MUCH GOOD WORK TO

1047
00:39:59,172 --> 00:40:01,074
DO SO THIS--THIS IS THE BEST JOB

1048
00:40:01,074 --> 00:40:03,510
TO HAVE.

1049
00:40:03,510 --> 00:40:04,811
THIS IS THE BEST PLACE TO DO IT

1050
00:40:04,811 --> 00:40:06,646
AND I THINK I'M JUST THRILLED

1051
00:40:06,646 --> 00:40:09,682
WITH WHAT IS THE OPPORTUNITY FOR

1052
00:40:09,682 --> 00:40:10,417
THE FUTURE.

1053
00:40:10,417 --> 00:40:12,118
AND THAT'S MY LAST SLIDE.

1054
00:40:12,118 --> 00:40:20,493
SO THANK YOU VERY MUCH AND I

1055
00:40:20,493 --> 00:40:21,261
WILL TAKE QUESTIONS.

1056
00:40:21,261 --> 00:40:23,963
>> FLOOR IS NOW OPEN FOR

1057
00:40:23,963 --> 00:40:25,799
QUESTIONS, RECOGNIZING

1058
00:40:25,799 --> 00:40:26,166
DR. CORONADO.

1059
00:40:26,166 --> 00:40:28,034
>> FIRST OF ALL
CONGRATULATIONS

1060
00:40:28,034 --> 00:40:29,769
FOR HAVING BEEN HERE FOR 6

1061
00:40:29,769 --> 00:40:31,371
MONTHS AND PRESENTING THAT

1062
00:40:31,371 --> 00:40:31,738
REPORT.

1063
00:40:31,738 --> 00:40:34,841
I FEEL REALLY INSPIRED BY THE

1064
00:40:34,841 --> 00:40:41,815
NEW FOCUS ON DATA, DATA

1065
00:40:41,815 --> 00:40:42,382
HARMONIZATION, DATA SCIENCE

1066
00:40:42,382 --> 00:40:44,150
BECAUSE I THINK THAT WE'VE BEEN,

1067
00:40:44,150 --> 00:40:45,685
YOU KNOW IN OUR RESEARCH PROGECS

1068
00:40:45,685 --> 00:40:48,288
HAVE BEEN DOING A LOT MORE DATA

1069
00:40:48,288 --> 00:40:49,489
SHARING THAN WE HAVE IN THE PAST

1070
00:40:49,489 --> 00:40:51,791
AND WE'RE KIND OF IN THE NEW ERA

1071
00:40:51,791 --> 00:40:53,993
OF DATA AVAILABILITY AND DATA

1072
00:40:53,993 --> 00:40:56,296
SHARING AND I THINK IT'S TIME

1073
00:40:56,296 --> 00:40:59,699
THAT WE ALSO START THINKING

1074
00:40:59,699 --> 00:41:02,402
ABOUT HOW TO INCORPORATE

1075
00:41:02,402 --> 00:41:04,471
TRAINING AROUND USING THAT TO

1076
00:41:04,471 --> 00:41:07,574
OPEN OUR TRAINING GRANTS AND IN

1077
00:41:07,574 --> 00:41:08,174
OUR EDUCATIONAL PROGRAM FOR

1078
00:41:08,174 --> 00:41:09,876
THOSE OF US THAT ARE IN ACADEMEC

1079
00:41:09,876 --> 00:41:11,478
CENTERS BECAUSE I FEEL LIKE WE

1080
00:41:11,478 --> 00:41:13,446
NEED TO REALLY FOCUS ON TRAINING

1081
00:41:13,446 --> 00:41:14,414
THE NEXT GENERATION OF

1082
00:41:14,414 --> 00:41:18,151
SCIENTISTS TO BE ABLE TO ACCESS

1083
00:41:18,151 --> 00:41:19,452
AND USE ALL OF THE AVAILABLE

1084
00:41:19,452 --> 00:41:24,390
DATA THAT WILL BE AT THEIR

1085
00:41:24,390 --> 00:41:24,958
DISPOSAL.

1086
00:41:24,958 --> 00:41:25,592
>> YEAH, HUNDRED PERCENT
AGREE

1087
00:41:25,592 --> 00:41:28,328
AND I DO THINK IT'S IMPORTANT

1088
00:41:28,328 --> 00:41:30,797
THAT WE ARE WORKING IN THOSE

1089
00:41:30,797 --> 00:41:31,965
SPACES BETWEEN, RIGHT, THE DATA

1090
00:41:31,965 --> 00:41:34,234
SCIENCE AND OUR TRAINING BRANCH

1091
00:41:34,234 --> 00:41:36,436
AND MAKING SURE THAT WE'RE

1092
00:41:36,436 --> 00:41:38,371
PREPARING OUR NEXT GENERATION

1093
00:41:38,371 --> 00:41:39,572
WELL, AND PREPARING US OLDER

1094
00:41:39,572 --> 00:41:41,441
FOLKS TO BE ABLE TO NAVIGATE

1095
00:41:41,441 --> 00:41:47,347
THIS AS WELL, TOO.

1096
00:41:47,347 --> 00:41:47,814
>> DR. HAYES-DIXON.

1097
00:41:47,814 --> 00:41:49,549
>> THANK YOU VERY MUCH FOR
THAT

1098
00:41:49,549 --> 00:41:50,583
EXCELLENT REPORT, I'M REALLY

1099
00:41:50,583 --> 00:41:52,418
PLEASED TO SEE THE INCREASE THAT

1100
00:41:52,418 --> 00:41:56,456
WE HAVE FOR FUNDING 1 FOR EARLY

1101
00:41:56,456 --> 00:41:56,890
STAGE INVESTIGATORS.

1102
00:41:56,890 --> 00:41:58,324
I REMEMBER SEVERAL YEARS AGO IN

1103
00:41:58,324 --> 00:42:00,160
THIS COMMITTEE WE DISCUSSED HOW

1104
00:42:00,160 --> 00:42:01,461
IMPORTANT THAT WAS SO IT'S FIES

1105
00:42:01,461 --> 00:42:03,630
TO SEE THAT COME TO FRUALITY

1106
00:42:03,630 --> 00:42:05,965
AFTER WE MADE THOSE

1107
00:42:05,965 --> 00:42:06,332
RECOMMENDATIONS.

1108
00:42:06,332 --> 00:42:10,436
I'M WONDERING IN THAT GAP

1109
00:42:10,436 --> 00:42:12,071
BETWEEN THE NOW AND PROPOSED

1110
00:42:12,071 --> 00:42:15,608
BUDGET AND THE ACTUAL BUDGET,

1111
00:42:15,608 --> 00:42:19,012
WHO WERE THE LEADERS, WAS IT A

1112
00:42:19,012 --> 00:42:20,079
DECREASE IN FUNDING--YOU

1113
00:42:20,079 --> 00:42:24,284
MENTIONED THE ITEMS OR PROGRAMS

1114
00:42:24,284 --> 00:42:25,752
THAT WERE PROTECTED.

1115
00:42:25,752 --> 00:42:28,154
WHAT CAN WE EXPECT AS FAR AS

1116
00:42:28,154 --> 00:42:29,923
WERE THERE PROGRAMS ELIMINATED

1117
00:42:29,923 --> 00:42:31,824
OR REDUCED FUNDING IN SOME

1118
00:42:31,824 --> 00:42:34,360
PROGRAMS. 

1119
00:42:34,360 --> 00:42:36,763
>> IT WAS SHAVES ACROSS
OFF

1120
00:42:36,763 --> 00:42:38,431
EXISTING GRANTS, IT WAS BETTER

1121
00:42:38,431 --> 00:42:39,699
THAN THE PROYECTED, SO IN THE

1122
00:42:39,699 --> 00:42:42,435
INTERIM BUDGET WE WERE CUTTING

1123
00:42:42,435 --> 00:42:46,973
6% AND WE RATCHETED THAT BACK TO

1124
00:42:46,973 --> 00:42:50,543
5 AND WITH THAT WE'RE ABLE TO

1125
00:42:50,543 --> 00:42:51,044
KEEP THINGS GOING.

1126
00:42:51,044 --> 00:42:52,912
NAND I WILL SAY, I SAID THIS IN

1127
00:42:52,912 --> 00:42:54,547
THE LAST TALK, WHEN WE DID CUTS

1128
00:42:54,547 --> 00:42:56,950
IT WAS ACROSS THE BOARD, IT WAS

1129
00:42:56,950 --> 00:42:57,650
INTRAMURAL AND EXTRAMURAL

1130
00:42:57,650 --> 00:43:00,553
PROGRAM, IT WAS THE ONLY THINGS

1131
00:43:00,553 --> 00:43:04,657
THAT GOT PRESERVED WERE CANCER

1132
00:43:04,657 --> 00:43:06,859
CENTERS AND TRAINING.

1133
00:43:06,859 --> 00:43:09,262
>> WOW, THANK YOU.

1134
00:43:09,262 --> 00:43:09,996
>> YEAH.

1135
00:43:09,996 --> 00:43:10,563
>> [INDISCERNIBLE], CANCER

1136
00:43:10,563 --> 00:43:10,830
INSTITUTE.

1137
00:43:10,830 --> 00:43:12,532
>> CAN YOU MOVE YOUR MIC
UP

1138
00:43:12,532 --> 00:43:16,069
CLOSER NHOW IS THIS?

1139
00:43:16,069 --> 00:43:17,070
>> ALL RIGHT, CANCER
INSTITUTE,

1140
00:43:17,070 --> 00:43:19,872
I WANT TO FOLLOW UP ON YOUR

1141
00:43:19,872 --> 00:43:22,976
APPOINTMENT OF DR. KIBBIE AS NEW

1142
00:43:22,976 --> 00:43:24,844
DEPUTY DIRECTOR, I THINK THAT IS

1143
00:43:24,844 --> 00:43:26,346
SO CRITICAL AND IMPORTANT AND

1144
00:43:26,346 --> 00:43:31,050
VERY THRILLED ABOUT IT, I WAS AT

1145
00:43:31,050 --> 00:43:32,418
THE CANCER CENTERS INFORMATICS

1146
00:43:32,418 --> 00:43:33,186
SOCIETY MEETING, AND SPOKE THERE

1147
00:43:33,186 --> 00:43:35,255
AND I THINK WHAT WE NEED TO DO

1148
00:43:35,255 --> 00:43:38,024
IN THE SPACE OF DATA SCIENCE AND

1149
00:43:38,024 --> 00:43:41,561
AI IS REALLY THINK ABOUT HOW IT

1150
00:43:41,561 --> 00:43:43,096
TOUCHES EVERY ASPECT OF OUR

1151
00:43:43,096 --> 00:43:45,031
SCIENCE AND SO CLINICAL TRIALS,

1152
00:43:45,031 --> 00:43:46,199
EVERYBODY HAS ALREADY THOUGHT

1153
00:43:46,199 --> 00:43:48,601
ABOUT DATA SHARING ON POPULATION

1154
00:43:48,601 --> 00:43:51,037
LEVELS IS A BIG GOAL BUT ALSO

1155
00:43:51,037 --> 00:43:54,674
THIS PROGRAM CALLED

1156
00:43:54,674 --> 00:43:58,044
COMPLIMENTARY WHICH I SAW IS

1157
00:43:58,044 --> 00:44:02,215
LIKE AIMING TO MODEL EXPERIMENTS

1158
00:44:02,215 --> 00:44:03,716
BEFORE WE DO THEM IS REALLY

1159
00:44:03,716 --> 00:44:06,052
GOING TO BE THE FUTURE AND WE

1160
00:44:06,052 --> 00:44:09,656
CAN TARGET OUR APPROACHES

1161
00:44:09,656 --> 00:44:11,958
INVITRO AFTER HAVING OR IN VIVO

1162
00:44:11,958 --> 00:44:14,494
AFTER HAVING DONE THE INSILIC O

1163
00:44:14,494 --> 00:44:17,463
MODERATION AND A VIRTUOUS CYCLE

1164
00:44:17,463 --> 00:44:19,198
WHERE WE INTEGRATE INSILL COWILL

1165
00:44:19,198 --> 00:44:20,733
BE SO CRITICAL SO I'M VERY

1166
00:44:20,733 --> 00:44:23,136
EXCITED THAT YOU ARE MOVE

1167
00:44:23,136 --> 00:44:24,437
NOTHING THAT DIRECTION AND I'M

1168
00:44:24,437 --> 00:44:26,439
LOOKING FORWARD TO WORKING WITH

1169
00:44:26,439 --> 00:44:31,177
DR. KIERK BBIE ON THIS.

1170
00:44:31,177 --> 00:44:34,614
NYEAH, SIMULATIONS, DIGITAL TWIN

1171
00:44:34,614 --> 00:44:36,616
TYPE--THERE'S SO MANY WAYS WE

1172
00:44:36,616 --> 00:44:37,517
CAN USE DATA.

1173
00:44:37,517 --> 00:44:40,353
SO YEAH.

1174
00:44:40,353 --> 00:44:41,020
NTROY.

1175
00:44:41,020 --> 00:44:42,455
>> TROY [INDISCERNIBLE]
WITH UC

1176
00:44:42,455 --> 00:44:43,623
DAVIS CANCER CENTER, I WAS GOING

1177
00:44:43,623 --> 00:44:45,024
TO SAY SOMETHING ELSE BUT

1178
00:44:45,024 --> 00:44:46,292
FOLLOWING ON THOSE COMMENTS, I

1179
00:44:46,292 --> 00:44:50,196
WILL ALSO MAKE THE POINT THAT

1180
00:44:50,196 --> 00:44:51,130
THERE'S ALSO THE REVERSE

1181
00:44:51,130 --> 00:44:52,398
EICATION FOR PEOPLE ENTERING

1182
00:44:52,398 --> 00:44:54,067
CANCER RESEARCH FROM THE PURE AI

1183
00:44:54,067 --> 00:44:55,735
FIELD, A LOT OF EXCITEMENT, A

1184
00:44:55,735 --> 00:44:57,470
LOT OF HYPE GOING ON IN THE PURE

1185
00:44:57,470 --> 00:45:00,640
AI FIELD AND I THINK THEY'RE NOT

1186
00:45:00,640 --> 00:45:02,075
GOING TO DO THIS WITHOUT US AND

1187
00:45:02,075 --> 00:45:03,743
JUST TO MAKE THAT POINT BUT MY

1188
00:45:03,743 --> 00:45:05,712
QUESTION WAS ACTUALLY BACK TO

1189
00:45:05,712 --> 00:45:08,448
THE ESI INVESTIGATORS, OF

1190
00:45:08,448 --> 00:45:09,615
COURSE, NO BRAINER, THE RIGHT

1191
00:45:09,615 --> 00:45:14,087
THING TO DO, I WAS JUST

1192
00:45:14,087 --> 00:45:15,855
WONDERING, WHAT'S THE BALANCE,

1193
00:45:15,855 --> 00:45:18,524
TOTAL FUNDING SAY FOR RO-1S TO

1194
00:45:18,524 --> 00:45:22,862
GO TO ESA VERSUS ROLL RO-1, IS

1195
00:45:22,862 --> 00:45:24,997
IT A HUGE DECISION TO MAKE OR IS

1196
00:45:24,997 --> 00:45:27,900
IT A SMALL FRACTION ANYWAY?

1197
00:45:27,900 --> 00:45:28,801
>> IT'S RELATIVELY SMALL.

1198
00:45:28,801 --> 00:45:30,403
I SHOULD KNOW THE PERCENTAGE,

1199
00:45:30,403 --> 00:45:33,072
IT'S UNDER 10% FROM THE ESI POOL

1200
00:45:33,072 --> 00:45:36,376
SO IT'S EASIER TO MOVE NYEAH.

1201
00:45:36,376 --> 00:45:37,944
BUT IT'S OOLS ALSO GETTING UP TO

1202
00:45:37,944 --> 00:45:39,579
17% IS WHERE YOU ARE STARTING TO

1203
00:45:39,579 --> 00:45:41,748
FEEL LIKE THESE ARE GOOD AND I

1204
00:45:41,748 --> 00:45:43,149
CAN TELL THESE CENTERS NEED

1205
00:45:43,149 --> 00:45:45,218
MORE, I DON'T KNOW WHERE THE

1206
00:45:45,218 --> 00:45:47,954
INFLECTION POINT IS, IT'S NOT AT

1207
00:45:47,954 --> 00:45:50,723
10 SO 17 WAS AN AMOUNT WE COULD

1208
00:45:50,723 --> 00:45:52,225
AFFORD BUT ALSO VERY REALISTIC

1209
00:45:52,225 --> 00:45:54,894
THAT THOSE ARE GOOD GRANTS THAT

1210
00:45:54,894 --> 00:45:57,029
ARE GETTING FUNDED.

1211
00:45:57,029 --> 00:46:01,868
>> OKAY, SO WE HAVE SAMUAL

1212
00:46:01,868 --> 00:46:02,602
[INDISCERNIBLE] UNIVERSITY OF

1213
00:46:02,602 --> 00:46:02,869
CHICAGO.

1214
00:46:02,869 --> 00:46:04,370
ONE THING THAT CONTINUES TO BE

1215
00:46:04,370 --> 00:46:05,438
AN ISSUE GOING BACK TO CLINICAL

1216
00:46:05,438 --> 00:46:07,774
TRIALS AND THE LACK OF

1217
00:46:07,774 --> 00:46:08,875
STANDARDIZED DATA FROM PROTOCOLS

1218
00:46:08,875 --> 00:46:12,845
AND I AM FLAD TO SEE

1219
00:46:12,845 --> 00:46:13,780
DR. DOROSHOW HERE BECAUSE WE'VE

1220
00:46:13,780 --> 00:46:15,515
TALKED ABOUT THIS MANY TIMES BUT

1221
00:46:15,515 --> 00:46:17,083
I WOULD LOVE TO SEE NETWORK CI

1222
00:46:17,083 --> 00:46:19,018
TAKE A STRONG LEADERSHIP STANCE

1223
00:46:19,018 --> 00:46:22,555
HERE BECAUSE OF THE AMOUNT OF

1224
00:46:22,555 --> 00:46:28,027
PROTOCOLS WRITTEN AND THINK

1225
00:46:28,027 --> 00:46:33,132
ABOUT THE ENTIRE AND EXCLUSION

1226
00:46:33,132 --> 00:46:34,600
INFORMATION FOR THE LEADERSHIP

1227
00:46:34,600 --> 00:46:35,468
TRIALS SOPHISTICATEDY WE WOULD

1228
00:46:35,468 --> 00:46:38,871
LOVE TO SEE NKRRK I TAKE A LONG

1229
00:46:38,871 --> 00:46:39,839
LEADERSHIP POSITION THERE.

1230
00:46:39,839 --> 00:46:41,441
>> ABSOLUTELY, WE HAD A
SUMMIT

1231
00:46:41,441 --> 00:46:43,109
FOR 2 DAYS ON MOVING ELEMENTS

1232
00:46:43,109 --> 00:46:45,311
THAT WAY, BUT ABSOLUTELY THAT'S

1233
00:46:45,311 --> 00:46:47,747
1 WAY THAT DOESN'T COST A LOT OF

1234
00:46:47,747 --> 00:46:48,481
MONEY, EVERYTHING COSTS MONEY

1235
00:46:48,481 --> 00:46:52,118
BUT WHERE WE CAN GET A LOT OF

1236
00:46:52,118 --> 00:46:57,023
BEANG FOR OUR BUCK NLUIS?

1237
00:46:57,023 --> 00:46:58,324
>> CONGRATULESS AND
FANTASTIC

1238
00:46:58,324 --> 00:46:59,292
PRESENTATION, GREAT TO BE HERE

1239
00:46:59,292 --> 00:47:03,729
IN PERSON, I THINK YOUR EMPHASIS

1240
00:47:03,729 --> 00:47:04,831
ON DECENTRALIZE TRIALS AND

1241
00:47:04,831 --> 00:47:05,698
REALLY IMPORTANT.

1242
00:47:05,698 --> 00:47:08,134
I THINK TELL ALLOW US TO MOVE

1243
00:47:08,134 --> 00:47:11,671
SPEED IN A WAY THAT'S FASTER AND

1244
00:47:11,671 --> 00:47:13,473
IT WILL PROVIDE ACCESS TO

1245
00:47:13,473 --> 00:47:14,874
POPULATIONS THAT TYPICALLY DON'T

1246
00:47:14,874 --> 00:47:15,708
HAVE ACCESS TO CLINICAL TRIALS,

1247
00:47:15,708 --> 00:47:17,343
IN A WAY THAT'S VERY UNIQUE.

1248
00:47:17,343 --> 00:47:20,246
SOME OF THE BARRIERS TO THIS,

1249
00:47:20,246 --> 00:47:25,518
EVEN WE'VE BEEN FINDING

1250
00:47:25,518 --> 00:47:26,586
[INDISCERNIBLE] FROM MEMORIAL

1251
00:47:26,586 --> 00:47:28,221
SLOAN KETTERRING, IS THAT THE

1252
00:47:28,221 --> 00:47:30,022
LICENSING FOR MDs AT THE STATE

1253
00:47:30,022 --> 00:47:31,123
LEVEL IS RESPHRICTING OUR

1254
00:47:31,123 --> 00:47:35,328
ABILITY TO TALK TO OR EVEN

1255
00:47:35,328 --> 00:47:36,062
ENGAGE WITH PEASHTS ACROSS

1256
00:47:36,062 --> 00:47:36,896
STRAIGHT LINES AND I THINK THAT

1257
00:47:36,896 --> 00:47:38,498
WOULD BE SOMETHING TO EMPHASIZE

1258
00:47:38,498 --> 00:47:40,132
FROM THIS LEVEL BECAUSE WE CAN

1259
00:47:40,132 --> 00:47:41,534
PROBABLY INFLUENCE THAT IN A

1260
00:47:41,534 --> 00:47:43,536
UNIQUE WAY, THE OTHER THINGS ARE

1261
00:47:43,536 --> 00:47:46,172
SIMPLELE THINGS LIKE DATA

1262
00:47:46,172 --> 00:47:47,440
TRANSFER GREEMS, MATERIAL

1263
00:47:47,440 --> 00:47:49,375
TRANSFER GROAMENTS, EVERY CENTER

1264
00:47:49,375 --> 00:47:51,377
HAS ITS OWN UNIQUE FORMS AND IF

1265
00:47:51,377 --> 00:47:53,279
WE COULD CENTRALIZE THAT, THOSE

1266
00:47:53,279 --> 00:47:56,048
2 SIMPLE MANEUVERS WOULD HAVE A

1267
00:47:56,048 --> 00:47:59,652
TREMENDOUS IMPACT IN YOUR

1268
00:47:59,652 --> 00:47:59,886
VISION.

1269
00:47:59,886 --> 00:48:00,286
>> WELL, GREAT.

1270
00:48:00,286 --> 00:48:04,123
I'M PLAID YOU SAID THAT, I HAVE

1271
00:48:04,123 --> 00:48:07,126
ALSO ADVOCATED FOR THE LICENSURE

1272
00:48:07,126 --> 00:48:10,196
FOR A TELEHEALTH, COMING FROM A

1273
00:48:10,196 --> 00:48:11,397
KINYITATE IN TENNESSEE, IT MAKES

1274
00:48:11,397 --> 00:48:12,999
A BIG DIFFERENCE, THAT IS NOT

1275
00:48:12,999 --> 00:48:14,166
SOMETHING WE CAN CHANGE BUT IT

1276
00:48:14,166 --> 00:48:17,470
IS SOMETHING WE ALL NEED TO BE

1277
00:48:17,470 --> 00:48:21,240
CLEAR ABOUT WHERE THAT HAS

1278
00:48:21,240 --> 00:48:21,941
IMPACTS FOR PATIENTS.

1279
00:48:21,941 --> 00:48:22,909
NWE'RE GOING TO TAKE 3 MORE

1280
00:48:22,909 --> 00:48:24,310
QUESTIONS AND I HAVE THEM IN

1281
00:48:24,310 --> 00:48:26,746
ORDER SO I'M GOING TO START WITH

1282
00:48:26,746 --> 00:48:30,716
KAREN, AND THEN WE'LL GO TO

1283
00:48:30,716 --> 00:48:33,719
ISABELL AND THEN DR. NEWMAN.

1284
00:48:33,719 --> 00:48:34,687
>> SO GRIT TALK.

1285
00:48:34,687 --> 00:48:37,623
I HAVE 2 IDEAS FOR SUGGESTIONS,

1286
00:48:37,623 --> 00:48:39,191
1 WE'RE GETTING A LOT OF DATA

1287
00:48:39,191 --> 00:48:41,027
SCIENCE AND AI BUT WE HAVEN'T

1288
00:48:41,027 --> 00:48:42,695
REALLY TALKED ABOUT DIGITAL

1289
00:48:42,695 --> 00:48:44,564
THERAPEUTIC ANDS THERE'S AN

1290
00:48:44,564 --> 00:48:47,099
ENTIRE LANDSCAPE FOR DIGITAL

1291
00:48:47,099 --> 00:48:48,968
THERAPEUTICS AS IT RELATES TO

1292
00:48:48,968 --> 00:48:50,770
BEHAVIOR WHICH IS INVOLVE INDEED

1293
00:48:50,770 --> 00:48:52,738
PRIMARY PREVENTION, CANCER

1294
00:48:52,738 --> 00:48:53,406
CONTROLS, SURVERIFIORSHIP

1295
00:48:53,406 --> 00:48:55,074
RESEARCH ALL ALONG THE ENTIRE

1296
00:48:55,074 --> 00:48:56,142
CONTINUUM, IT'S GROWING OUT

1297
00:48:56,142 --> 00:48:57,176
THERE, THE MARKETPLACE KNOWS

1298
00:48:57,176 --> 00:48:58,678
ABOUT IT AND SO DO PRIVATE

1299
00:48:58,678 --> 00:48:59,745
COMPANIES BUT WE'RE NOT REALLY

1300
00:48:59,745 --> 00:49:01,547
WHERE WE NEED TO BE IN TERMS OF

1301
00:49:01,547 --> 00:49:04,050
NCI AND WHAT WE'RE DOING TO

1302
00:49:04,050 --> 00:49:07,219
SUPPORT RESEARCH ABOUT HOW WELL

1303
00:49:07,219 --> 00:49:08,020
THESE THINGS WORK.

1304
00:49:08,020 --> 00:49:10,122
THE OTHER THING AS YOU THINK

1305
00:49:10,122 --> 00:49:11,591
ABOUT INFRASTRUCTURE AND WHAT

1306
00:49:11,591 --> 00:49:12,992
YOU WANT TO SUPPORT ESPECIALLY

1307
00:49:12,992 --> 00:49:17,563
AS YOU TAKE YOUR TOURS OF THE

1308
00:49:17,563 --> 00:49:20,199
NCORPS, WE LEARNED IN THE LAST 2

1309
00:49:20,199 --> 00:49:21,233
YEARS ESPECIALLY SINCE COVID

1310
00:49:21,233 --> 00:49:23,636
BECAUSE WE'VE GONE AND VISITED

1311
00:49:23,636 --> 00:49:25,738
ALL OF OUR NCORP SITES AT OUR

1312
00:49:25,738 --> 00:49:27,873
RESEARCH BASE, THERE'S AN

1313
00:49:27,873 --> 00:49:30,009
INCREDIBLE AMOUNT OF REDUNDANCY,

1314
00:49:30,009 --> 00:49:31,410
ESPECIAL LYE NOW THERE ARE

1315
00:49:31,410 --> 00:49:33,179
EXAMPLES WHERE YOU HAVE NCORPS

1316
00:49:33,179 --> 00:49:34,880
THAT ARE FUNDED NCORPS THAT

1317
00:49:34,880 --> 00:49:37,383
MAYBE ALSO SIT AT AN NCI

1318
00:49:37,383 --> 00:49:38,918
DESIGNATED CANCER CENTER, BURDEN

1319
00:49:38,918 --> 00:49:42,455
ON THE CRAs, THEY HAVE TO

1320
00:49:42,455 --> 00:49:43,723
REGISTER ALL THEIR PEASHTS IN

1321
00:49:43,723 --> 00:49:44,991
OPEN FOR YOUR TREATMENT TRIALS

1322
00:49:44,991 --> 00:49:46,626
AS WELL AS YOUR NCORPS TRIALS

1323
00:49:46,626 --> 00:49:47,827
AND THEN THEY HAVE TO TURN ARK

1324
00:49:47,827 --> 00:49:51,230
ROUND AND DO THE SAME THING

1325
00:49:51,230 --> 00:49:52,632
AGAIN IN NCORPS TO MEET ALL

1326
00:49:52,632 --> 00:49:54,233
THEIR CANCER CENTER REERMTS AND

1327
00:49:54,233 --> 00:49:55,868
FOLLOW ALL THEIR LOCAL METRICS.

1328
00:49:55,868 --> 00:49:59,171
IF WE WANT TO DECREASE BURDEN AT

1329
00:49:59,171 --> 00:50:01,707
THOSE SITES, WE HAVE TO LOOK AT

1330
00:50:01,707 --> 00:50:02,575
THAT KIND OF REDUNDANCY IN THE

1331
00:50:02,575 --> 00:50:05,678
SYSTEM AND GET THINGS TALKING TO

1332
00:50:05,678 --> 00:50:06,245
EACH OTHER BETTER.

1333
00:50:06,245 --> 00:50:09,915
AND THEN I DID HAVE 1 QUESTION,

1334
00:50:09,915 --> 00:50:12,284
WITH ALL THE EMPHASIS ON

1335
00:50:12,284 --> 00:50:13,586
COMMUNITY, IN TERMS OF THE

1336
00:50:13,586 --> 00:50:15,788
BUDGET CUTS, ASK THAT MEAN LIKE

1337
00:50:15,788 --> 00:50:17,690
THE NCORPS, ALL THOSE COMMUNITY

1338
00:50:17,690 --> 00:50:19,091
BASED NCORPS, AND COMMUNITY

1339
00:50:19,091 --> 00:50:21,327
BASED NCORPS ARE GOING TO GET

1340
00:50:21,327 --> 00:50:23,429
BUDGET CUTS, THAT'S HARD BECAUSE

1341
00:50:23,429 --> 00:50:24,764
THEY'RE ALREADY UNDERFUNDED.

1342
00:50:24,764 --> 00:50:25,131
NI AGREE.

1343
00:50:25,131 --> 00:50:27,233
AND THAT THERE'S A LOT OF THINGS

1344
00:50:27,233 --> 00:50:30,236
WE DON'T FIND APPROPRIATELY.

1345
00:50:30,236 --> 00:50:40,680
>> WE HAVE ISA BELL AND

1346
00:50:41,781 --> 00:50:42,148
DR. [INDISCERNIBLE].

1347
00:50:42,148 --> 00:50:43,149
NI LOVE THE COMMENTS AND THE

1348
00:50:43,149 --> 00:50:44,850
IDEA OF COMMUNITY I LIKE TO HEAR

1349
00:50:44,850 --> 00:50:47,653
THAT RESONATE BUT TO LISA'S

1350
00:50:47,653 --> 00:50:48,487
POINT CLINICAL TRIALS, 1 OF THE

1351
00:50:48,487 --> 00:50:50,790
THINGS SITTING ON THE IRB FOR

1352
00:50:50,790 --> 00:50:52,324
THE ALL OF US RESEARCH PROGRAM

1353
00:50:52,324 --> 00:50:54,860
IS A CONSISTENT NOTE THAT

1354
00:50:54,860 --> 00:50:57,263
CONSORTIA THAT THEY'RE HAVING

1355
00:50:57,263 --> 00:50:58,664
PROBLEMS ENROLLING LOW LITERACY

1356
00:50:58,664 --> 00:51:02,635
AND SPANISH SPEAKING BECAUSE OF

1357
00:51:02,635 --> 00:51:04,170
THE LONG CONSENTINGS.

1358
00:51:04,170 --> 00:51:05,971
I'VE SEEN THAT CONTINUALLY, A

1359
00:51:05,971 --> 00:51:07,406
CONCERN, NOT A COMPLAINT BUT A

1360
00:51:07,406 --> 00:51:08,674
CONCERN AND I'M WONDERING IF

1361
00:51:08,674 --> 00:51:11,310
WHILE WE'RE GOING TO MAKE ENTRY

1362
00:51:11,310 --> 00:51:13,145
INTO CLINICAL TRIALS A TAD

1363
00:51:13,145 --> 00:51:15,147
EASIER IT STILL MAY BE 1 OF THE

1364
00:51:15,147 --> 00:51:17,583
MAJOR OBSTACLES TO GETTING

1365
00:51:17,583 --> 00:51:18,284
PEOPLE UNDERREPRESENTED PEOPLE

1366
00:51:18,284 --> 00:51:19,785
INTO THESE TRIALS SOIME

1367
00:51:19,785 --> 00:51:22,388
WONDERING HOW NKRRK I CAN LEAD

1368
00:51:22,388 --> 00:51:26,158
ON PERHAPS LOOKING FOR BETTER

1369
00:51:26,158 --> 00:51:27,760
CONSENTED MODELS FOR DEFINITE

1370
00:51:27,760 --> 00:51:28,227
COMMUNITIES.

1371
00:51:28,227 --> 00:51:31,831
I KNOW UCLA IS USING VIDEO

1372
00:51:31,831 --> 00:51:33,466
APPROACHES AND I'M WONDERING HOW

1373
00:51:33,466 --> 00:51:34,867
NCI CAN LOOK AT THIS BECAUSE

1374
00:51:34,867 --> 00:51:37,169
THEY REALLY NEED TO CHAIMPLE THE

1375
00:51:37,169 --> 00:51:39,238
CONSENT IN IN MANY WAYS,

1376
00:51:39,238 --> 00:51:43,142
EVERYBODY SAYS THEY'RE TOO ALONG

1377
00:51:43,142 --> 00:51:45,578
ANYWAY, FOR LIT RASE MODEL EXPE

1378
00:51:45,578 --> 00:51:46,345
OTHER MONOLINGICAL COMMUNITIES,

1379
00:51:46,345 --> 00:51:46,712
IT'S DIFFICULT.

1380
00:51:46,712 --> 00:51:47,413
THE OTHER THING I WANT TO

1381
00:51:47,413 --> 00:51:48,914
MENTION THAT I HAVE A CONCERN

1382
00:51:48,914 --> 00:51:51,317
ABOUT IS I LOVE THE ADVANCES,

1383
00:51:51,317 --> 00:51:52,885
THEY ALL SOUND GREAT,

1384
00:51:52,885 --> 00:51:54,186
EVERYBODY'S EXCITED, WE HAVE ALL

1385
00:51:54,186 --> 00:51:55,354
THIS FABULOUS MOVEMENT FORWARD,

1386
00:51:55,354 --> 00:51:56,789
WHAT I'M CONCERNED IS THERE ARE

1387
00:51:56,789 --> 00:51:59,425
STILL COMMUNITIES WHO ARE NOT

1388
00:51:59,425 --> 00:52:01,660
GETTING BASIC SCREENING WHO ARE

1389
00:52:01,660 --> 00:52:05,564
FALLING EVENT FURTHER BEHIND IN

1390
00:52:05,564 --> 00:52:06,699
TERMS OF UNDERSTANDING WHAT'S

1391
00:52:06,699 --> 00:52:08,601
GOING ON IN SCIENCE EVEN AI, AS

1392
00:52:08,601 --> 00:52:11,270
I SAY TO THE AI EXPERTS YOU

1393
00:52:11,270 --> 00:52:12,571
AREOT TENTH FLOOR AND CONSUMERS

1394
00:52:12,571 --> 00:52:13,873
AND PATIENTS ARE ARE IN THE

1395
00:52:13,873 --> 00:52:15,040
BASEMENT ABOUT WHAT THE HECK AND

1396
00:52:15,040 --> 00:52:18,277
AI AND HOW DOES IT INTERSECT IN

1397
00:52:18,277 --> 00:52:19,645
THEIR LIVES, SO COMMUNITY IS

1398
00:52:19,645 --> 00:52:20,980
CRUCIAL TO MAKING THAT BRIDGE OR

1399
00:52:20,980 --> 00:52:22,047
CONNECTION, WHAT ARE YOU GOING

1400
00:52:22,047 --> 00:52:27,753
TO DO ABOUT EDUCATION AND TO

1401
00:52:27,753 --> 00:52:29,922
MAKE SURE THE BASIC FOCUS ON

1402
00:52:29,922 --> 00:52:32,091
THESE SAME OLD STANDARDS AND

1403
00:52:32,091 --> 00:52:34,393
SAME OLD SCREENINGS ARE GOING TO

1404
00:52:34,393 --> 00:52:36,095
STILL BE FRONT AND CENTER FOR

1405
00:52:36,095 --> 00:52:37,530
NCI BECAUSE I'M VERY CONCERNED,

1406
00:52:37,530 --> 00:52:39,932
WE'RE ALL RUSHING THIS WAY AND

1407
00:52:39,932 --> 00:52:41,100
WE'RE LEAVING--I THINK THAT'S

1408
00:52:41,100 --> 00:52:42,434
WHERE FOR EXAMPLE, THE NATIONAL

1409
00:52:42,434 --> 00:52:44,837
CANCER PLAN IS INKRED EBLLY

1410
00:52:44,837 --> 00:52:46,272
HELPFUL, IT KEEPS US BALANCED,

1411
00:52:46,272 --> 00:52:48,207
AND PREVENTION AND EARLY

1412
00:52:48,207 --> 00:52:50,910
DETECTION ARE 2 GOALS AND

1413
00:52:50,910 --> 00:52:51,744
DEVELOPING ADVANCED THERAPEUTICS

1414
00:52:51,744 --> 00:52:56,315
IS ONLY 1, SO, IT IS FRONT OF

1415
00:52:56,315 --> 00:52:57,650
MIND AND IT IS IMPORTANT PART OF

1416
00:52:57,650 --> 00:52:59,652
WHAT WE DO IN THE RESEARCH SPACE

1417
00:52:59,652 --> 00:53:01,053
AND TO THE OTHER POINT, I THINK

1418
00:53:01,053 --> 00:53:02,354
EVERYTHING IS ON THE TABLE, I

1419
00:53:02,354 --> 00:53:04,223
DON'T KNOW IF YOU WERE AT THE

1420
00:53:04,223 --> 00:53:07,059
COMMITTEE YESTERDAY, WHERE WE

1421
00:53:07,059 --> 00:53:09,495
TALKED ABOUT THE PRAGMATIC LUNG

1422
00:53:09,495 --> 00:53:12,798
TRIAL, THAT WAS AN EXAMPLE WHERE

1423
00:53:12,798 --> 00:53:13,933
THEY REALLY--THE PUSH OF THE

1424
00:53:13,933 --> 00:53:17,369
TBROWP WAS HOW LOW COULD YOU GO

1425
00:53:17,369 --> 00:53:18,904
IN TERMS OF DATA COLLECTION BUT

1426
00:53:18,904 --> 00:53:22,074
ALSO THE CONSENT FORM AND JIM,

1427
00:53:22,074 --> 00:53:24,610
THE CONSENT FORM AND 8 PAGES

1428
00:53:24,610 --> 00:53:25,377
LONG.

1429
00:53:25,377 --> 00:53:25,578
RIGHT.

1430
00:53:25,578 --> 00:53:29,181
AND AVAILABLE IN SPANISH, RIGHT?

1431
00:53:29,181 --> 00:53:30,616
SO I THINK WE NEED TO BE ABLE TO

1432
00:53:30,616 --> 00:53:32,685
THINK ABOUT HOW WE REACH OTHER

1433
00:53:32,685 --> 00:53:33,752
COMMUNITIES AS WELL, YOU KNOW WE

1434
00:53:33,752 --> 00:53:36,288
KNOW THERE ARE A LOT OF LANGUAGE

1435
00:53:36,288 --> 00:53:38,023
ISSUES, AS WELL AS JUST THE

1436
00:53:38,023 --> 00:53:41,493
BARRIERS OF THE CONCEPT PROCESS.

1437
00:53:41,493 --> 00:53:42,995
>> OKAY, WE HAVE 1 MORE
AND WE

1438
00:53:42,995 --> 00:53:48,467
REALLY ARE TO MOVE ON.

1439
00:53:48,467 --> 00:53:51,170
>> WONDERFUL PRESENTATION
NPULL

1440
00:53:51,170 --> 00:53:51,637
IT CLOSER.

1441
00:53:51,637 --> 00:53:52,705
>> SO APPRECIATE THE
TBRAIT

1442
00:53:52,705 --> 00:53:55,441
PRESENTATION AND I WAS ALSO

1443
00:53:55,441 --> 00:53:57,776
PLEASED TO SEE YOU HIGHLIGHT

1444
00:53:57,776 --> 00:53:59,678
FLOABAL BURDEN THERE, IT'S VERY

1445
00:53:59,678 --> 00:54:02,147
IMPORTANT FOR US, AND AS WE ALL

1446
00:54:02,147 --> 00:54:06,252
KNOW THERE'S A

1447
00:54:06,252 --> 00:54:06,785
DISPROPORTIONATELY GROWING

1448
00:54:06,785 --> 00:54:07,753
[INDISCERNIBLE] AND THIS IS

1449
00:54:07,753 --> 00:54:10,322
RELEVANT TO US FOR JUST A COUPLE

1450
00:54:10,322 --> 00:54:10,689
REASONS.

1451
00:54:10,689 --> 00:54:14,193
ONE THING WITH YOUNG PEOPLE, BUT

1452
00:54:14,193 --> 00:54:15,628
FOR 1 THING OUR YOUNG PEOPLE

1453
00:54:15,628 --> 00:54:17,129
HAVE A REALLY STRONG APPETITE

1454
00:54:17,129 --> 00:54:19,832
AND THEY'RE OFTEN WITH GLOBAL

1455
00:54:19,832 --> 00:54:22,301
HEALTH AND CANCER EQUITY AND

1456
00:54:22,301 --> 00:54:25,404
ALSO UNDERSTANDING TUMOR

1457
00:54:25,404 --> 00:54:27,907
BIOLOGY, TUMOR GENOMICS AND

1458
00:54:27,907 --> 00:54:28,741
[INDISCERNIBLE] GENETICS IS

1459
00:54:28,741 --> 00:54:29,575
RELEVANT TO THE DIVERSE

1460
00:54:29,575 --> 00:54:30,676
POPULATION IN THE UNITED STATES,

1461
00:54:30,676 --> 00:54:35,214
BUT THERE'S A MIXED PICTURE IN

1462
00:54:35,214 --> 00:54:37,216
TERMS OF FINANCIALLY SUPPORTED

1463
00:54:37,216 --> 00:54:38,684
FLOABAL CANCER CONTROL EFFORTS

1464
00:54:38,684 --> 00:54:40,319
AND LOWER INCOME COUNTRIES, ON

1465
00:54:40,319 --> 00:54:42,922
THE 1 HAND U.S. DOLLARS GO A

1466
00:54:42,922 --> 00:54:45,557
LONG WAY, FROM COUNTRIES WITH

1467
00:54:45,557 --> 00:54:48,327
THE PROVIDING BASIC SUPPLIES,

1468
00:54:48,327 --> 00:54:49,628
LIKE--THESE PEOPLE CAN BE

1469
00:54:49,628 --> 00:54:50,229
[INDISCERNIBLE].

1470
00:54:50,229 --> 00:54:52,431
SO THIS' A LONG WAY WE CAN GO

1471
00:54:52,431 --> 00:54:54,833
THERE, ON THE OTHER HAND, THE

1472
00:54:54,833 --> 00:54:57,069
EXCHANGE PROGRAM ANDS GETTING

1473
00:54:57,069 --> 00:54:58,470
THROUGH THE RESEARCH, FROM POINT

1474
00:54:58,470 --> 00:55:01,240
A TO POINT B CAN BE VERY

1475
00:55:01,240 --> 00:55:02,408
EXTENSIVE SO I'M CURIOUS TO SEE

1476
00:55:02,408 --> 00:55:04,076
HOW HAVE YOU ALL THOSE ISSUES

1477
00:55:04,076 --> 00:55:06,712
FACTORING INTO OUR CURRENT

1478
00:55:06,712 --> 00:55:10,649
FINANCIAL CONSTRAINED EMPLOY.

1479
00:55:10,649 --> 00:55:11,917
>> YEAH, THEY'RE ALL
CONSERVED

1480
00:55:11,917 --> 00:55:13,886
ISSUES BUT THEY WON'T BE SERVED

1481
00:55:13,886 --> 00:55:16,188
ABOUT IF WE BACK INTO OUR CORNER

1482
00:55:16,188 --> 00:55:17,923
EMPLOY WE CAN ENHANCE EACH

1483
00:55:17,923 --> 00:55:18,724
OTHER'S LEARNING, THE OTHER

1484
00:55:18,724 --> 00:55:20,759
PIECE YOU PUT IN THERE AND THE

1485
00:55:20,759 --> 00:55:23,295
GEOGRAPHY IS VIRMTAL EXPOSURES,

1486
00:55:23,295 --> 00:55:24,463
AND CLIMATE CHANGE AND THESE ARE

1487
00:55:24,463 --> 00:55:26,131
ALL GOING TO HAVE REAL IMPACTS

1488
00:55:26,131 --> 00:55:28,067
ON CANCER THAT WE'RE NOT GOING

1489
00:55:28,067 --> 00:55:30,135
TO BE IMMUNE FROM EITHER SO WE

1490
00:55:30,135 --> 00:55:32,237
NEED TO PARTNER REAL EFFECTIVELY

1491
00:55:32,237 --> 00:55:36,875
AND I THINK YOUR COMMENTS ARE

1492
00:55:36,875 --> 00:55:39,745
PROBLEM MUSIC TO DR. LAFALL'S

1493
00:55:39,745 --> 00:55:41,246
EARS, NTHANK YOU FANTASTIC

1494
00:55:41,246 --> 00:55:45,985
DISCUSSION, THANK YOU VERY MUCH.

1495
00:55:45,985 --> 00:55:49,254
SO NEXT ON THE AA WE HAVE THE

1496
00:55:49,254 --> 00:55:54,293
LEGISLATIVE REPORT BROUGHT TO US

1497
00:55:54,293 --> 00:55:55,060
BY MRS. HOLOHAN.

1498
00:55:55,060 --> 00:55:56,128
>> GOOD MORPING PLEASURE
TO TALK

1499
00:55:56,128 --> 00:55:58,097
WITH YOU TODAY, I WILL TRY TO

1500
00:55:58,097 --> 00:56:00,733
GET THROUGH THIS AS QUICKLY AS I

1501
00:56:00,733 --> 00:56:04,536
CAN SO WE CAN HAVE SOME TIME FOR

1502
00:56:04,536 --> 00:56:08,440
QUESTIONS, I LET DR. RATHMEWELL,

1503
00:56:08,440 --> 00:56:09,508
L, GO WITHOUT TELLING ME HOW TO

1504
00:56:09,508 --> 00:56:12,945
DO THIS EMPLOY CAN I GET

1505
00:56:12,945 --> 00:56:15,547
TECHNICAL ASSISTANCE HERE,

1506
00:56:15,547 --> 00:56:15,781
PLEASE?

1507
00:56:15,781 --> 00:56:18,617
I'M USED TO SAYING NEXT SLIDE,

1508
00:56:18,617 --> 00:56:18,851
PLEASE.

1509
00:56:18,851 --> 00:56:29,228
IS THERE ANYBODY HERE?

1510
00:56:30,396 --> 00:56:31,563
THIS WILL BE REALLY BORING IF I

1511
00:56:31,563 --> 00:56:34,266
JUST TALK TO YOU.

1512
00:56:34,266 --> 00:56:34,833
THANK YOU.

1513
00:56:34,833 --> 00:56:36,802
I'M GOING TO TRY TO COVER

1514
00:56:36,802 --> 00:56:39,238
DETAILS THAT DR. RATISSUING

1515
00:56:39,238 --> 00:56:40,406
HMILL WENT THROUGH BUT I WILL

1516
00:56:40,406 --> 00:56:41,907
TRY TO MOVE THROUGH THEM QUICKLY

1517
00:56:41,907 --> 00:56:44,476
SO WE HAVE TIME WITH QUESTIONS,

1518
00:56:44,476 --> 00:56:46,345
OUR TEAM AND REALLY HAPPY TO

1519
00:56:46,345 --> 00:56:47,980
TALK TO BOARD MEMBERS OR STAFF,

1520
00:56:47,980 --> 00:56:50,616
WE HAVE A DETAILED LEGISLATIVE

1521
00:56:50,616 --> 00:56:51,216
MEETING MATERIALS THAT WILL

1522
00:56:51,216 --> 00:56:53,919
COVER MUCH MORE IN THE TIME WE

1523
00:56:53,919 --> 00:56:54,787
HAVE HERE TODAY.

1524
00:56:54,787 --> 00:57:03,028
IS THIS ME OR YOU?

1525
00:57:03,028 --> 00:57:03,228
OKAY.

1526
00:57:03,228 --> 00:57:03,796
ALL RIGHT.

1527
00:57:03,796 --> 00:57:06,899
I REALLY AM GOING TO BE ADA

1528
00:57:06,899 --> 00:57:13,605
DISADVANTAGE IF THE SLIDES DON'T

1529
00:57:13,605 --> 00:57:16,308
COME UP.

1530
00:57:16,308 --> 00:57:21,847
OKAY, SO, OUR APPROPRIATIONS

1531
00:57:21,847 --> 00:57:23,582
BILLS WERE COMPLETED VERY LATE

1532
00:57:23,582 --> 00:57:24,283
IN FY24.

1533
00:57:24,283 --> 00:57:26,618
OKAY, SO NOW I JUST PRESS THE

1534
00:57:26,618 --> 00:57:33,525
ARROW RIGHT IN IS THAT WHAT YOU

1535
00:57:33,525 --> 00:57:35,994
DID? 

1536
00:57:35,994 --> 00:57:36,829
OKAY, TERRIFIC, TERRIFIC, OKAY.

1537
00:57:36,829 --> 00:57:39,498
SO WE'RE GOING TO TALK ABOUT

1538
00:57:39,498 --> 00:57:40,432
FY25 APPROPRIATIONS, WHERE WE

1539
00:57:40,432 --> 00:57:41,934
ARE RIGHT NOW, LEGISLATIVE

1540
00:57:41,934 --> 00:57:44,403
ISSUES TO WATCH AND A BIT ABOUT

1541
00:57:44,403 --> 00:57:45,471
ENGAGEMENT ADVOCACY WHICH IS SO

1542
00:57:45,471 --> 00:57:48,874
IMPORTANT FOR EVERYONE IN THE

1543
00:57:48,874 --> 00:57:50,709
CANCER RESEARCH COMMUNITY.

1544
00:57:50,709 --> 00:57:53,679
DR. RATHMILL GAVE YOU THE BAD

1545
00:57:53,679 --> 00:57:55,614
NEWS AND TALKED A LITTLE BIT

1546
00:57:55,614 --> 00:57:59,451
ABOUT THE FY25 REQUEST AS WELL,

1547
00:57:59,451 --> 00:58:01,320
SO FOR 24, WE WERE REALLY

1548
00:58:01,320 --> 00:58:02,855
GRATIFIED TO SEE THAT CONGRESS,

1549
00:58:02,855 --> 00:58:04,857
I WILL ONLY FOCUS ON THE NCI

1550
00:58:04,857 --> 00:58:07,659
MEMBERS HERE, AS DR. RATHMILL

1551
00:58:07,659 --> 00:58:09,895
EXPLAINED, THEY INKRESSED BUDGET

1552
00:58:09,895 --> 00:58:11,196
BY 120 MILLION THERE IS AND THIS

1553
00:58:11,196 --> 00:58:13,298
IS NOT INTIGER DATABASE 95 CAN'T

1554
00:58:13,298 --> 00:58:15,267
GIVEN THE INKRED EBLLY DIFFICULT

1555
00:58:15,267 --> 00:58:17,035
BUDGET CAPS THEY WERE WORKING

1556
00:58:17,035 --> 00:58:18,737
WITH, THE FISCAL RESPONSIBILITY

1557
00:58:18,737 --> 00:58:20,506
ACT WHICH WAS THE DEBT LIMIT

1558
00:58:20,506 --> 00:58:23,041
DEAL THAT RAISED, AND SUSPENDED

1559
00:58:23,041 --> 00:58:25,110
THE DEBT LIMIT UNTIL

1560
00:58:25,110 --> 00:58:26,044
JANUARY 21st OF 25, WE ARE

1561
00:58:26,044 --> 00:58:27,779
ABOUT TO FACE THAT DEBT LIMIT

1562
00:58:27,779 --> 00:58:30,883
ISSUE AGAIN AND IT SET FUNDING

1563
00:58:30,883 --> 00:58:32,684
CAPS FOR DISCRETIONARY SPENDING

1564
00:58:32,684 --> 00:58:34,119
FOR BOTH DEFENSE AND NONDEFENSE

1565
00:58:34,119 --> 00:58:37,189
AND THOSE CAPS WERE FOR 24 AND

1566
00:58:37,189 --> 00:58:37,356
25.

1567
00:58:37,356 --> 00:58:39,191
TWENTY-FOUR WAS KEPT FLAT AT THE

1568
00:58:39,191 --> 00:58:40,592
FY23 LEVEL, THIS IS THE TOP

1569
00:58:40,592 --> 00:58:42,861
LINE, NOT EACH INDIVIDUAL

1570
00:58:42,861 --> 00:58:49,401
ACCOUNT AND FOR 25, THERE IS A

1571
00:58:49,401 --> 00:58:49,868
1% INCREASE ALLOWED.

1572
00:58:49,868 --> 00:58:51,170
DEFENSE HAD AN INN CREASE IN 24,

1573
00:58:51,170 --> 00:58:52,037
THAT WAS PART OF THE DEAL AND

1574
00:58:52,037 --> 00:58:54,907
THERE WERE A LOT OF CHALLENGES

1575
00:58:54,907 --> 00:58:56,275
IN ACTUALLY IMPLEMENTING THE

1576
00:58:56,275 --> 00:58:57,176
DEAL.

1577
00:58:57,176 --> 00:58:58,377
THERE WERE KEY SIDE AGREEMENTS

1578
00:58:58,377 --> 00:59:00,412
REACHED THAT WERE SEPARATE FROM

1579
00:59:00,412 --> 00:59:01,813
THE FISCAL RESPONSIBILITY ACT

1580
00:59:01,813 --> 00:59:05,217
THAT GOT DEMOCRATS TO SUPPORT

1581
00:59:05,217 --> 00:59:05,717
THIS PACKAGE.

1582
00:59:05,717 --> 00:59:08,220
IT WAS SORT OF THE CHALLENGES OF

1583
00:59:08,220 --> 00:59:09,621
IMPLEMENTING THOSE SIDE DEALS

1584
00:59:09,621 --> 00:59:12,024
THAT PRESENTED A LOT OF PROBLEMS

1585
00:59:12,024 --> 00:59:16,595
AND WILL HAVE REVERBERATIONS FOR

1586
00:59:16,595 --> 00:59:18,330
FY25 WHICH I WILL COVER IN A

1587
00:59:18,330 --> 00:59:19,965
MOMENT BECAUSE THE MOON SHOT

1588
00:59:19,965 --> 00:59:20,933
FUNDING WAS ENDING WHICH WE

1589
00:59:20,933 --> 00:59:24,203
KNEW, BUT IT WAS ENDING IN FY23,

1590
00:59:24,203 --> 00:59:26,205
THAT WAS A NET LOSS OF

1591
00:59:26,205 --> 00:59:27,406
$216 MILLION, SO MEN WITH HIGHER

1592
00:59:27,406 --> 00:59:30,075
WHEN YOU LOOK AT OUR 120 MILLION

1593
00:59:30,075 --> 00:59:31,810
INCREASE AND OUR DECREASE IN THE

1594
00:59:31,810 --> 00:59:34,913
MOON SHOT FUNDS ENDING IT'S A

1595
00:59:34,913 --> 00:59:35,581
96 MILLION-DOLLAR SHORT FALL OF

1596
00:59:35,581 --> 00:59:38,083
DOLLARS IN THE DOOR OF ANY TYPE.

1597
00:59:38,083 --> 00:59:40,352
SO THAT'S A SIGNIFICANT

1598
00:59:40,352 --> 00:59:41,153
CHALLENGE FOR NCI.

1599
00:59:41,153 --> 00:59:45,891
HERE IS GOOD NEWS ABOUT

1600
00:59:45,891 --> 00:59:46,725
APPROPRIATIONS, CONGRESSMAN TOM

1601
00:59:46,725 --> 00:59:47,993
COLE OF OKLAHOMA BECAME THE

1602
00:59:47,993 --> 00:59:50,929
CHAIR OF THE FULL APPROPRIATIONS

1603
00:59:50,929 --> 00:59:53,298
COMMITTEE IN APRIL, CONGRESSMAN

1604
00:59:53,298 --> 00:59:55,467
KATE GRAINCHLER HAD STEPPED DOWN

1605
00:59:55,467 --> 00:59:57,436
FROM THAT ROLE IN 24.

1606
00:59:57,436 --> 00:59:59,972
CHAIRMAN COLE NOW IS A LONG TIME

1607
00:59:59,972 --> 01:00:01,707
APPROPRIATOR, HE IS A REAL

1608
01:00:01,707 --> 01:00:04,076
CHAMPION OF BIOMEDICAL RESEARCH,

1609
01:00:04,076 --> 01:00:06,211
HE HAS MET WITH ALL OF THE NCI

1610
01:00:06,211 --> 01:00:07,379
DIRECTORS AND PAST SEVERAL

1611
01:00:07,379 --> 01:00:10,582
YEARS, I AM LOOKING FORWARD FOR

1612
01:00:10,582 --> 01:00:13,051
DR. RARK THMILL TO MEET HIM, HE

1613
01:00:13,051 --> 01:00:15,254
WORKS VERY EFFECTIVELY WITH HIS

1614
01:00:15,254 --> 01:00:16,855
DEMOCRATIC COUNTERPARTS.

1615
01:00:16,855 --> 01:00:18,023
HE AND CONGRESSWOMAN ROSA DELORA

1616
01:00:18,023 --> 01:00:20,259
RODRIGUEZ O OF CONNECTICUT IS AN

1617
01:00:20,259 --> 01:00:24,296
OVARIAN CANCER SURVIVER AND LONG

1618
01:00:24,296 --> 01:00:26,365
TIME CHAMPION OF NE H RESEARCH.

1619
01:00:26,365 --> 01:00:28,934
THEY WORK VERY CONSTRUCTIVELY

1620
01:00:28,934 --> 01:00:29,201
TOGETHER.

1621
01:00:29,201 --> 01:00:31,470
THEY BOTH SERVED ON THE LABOR

1622
01:00:31,470 --> 01:00:33,105
HHS SUBCOMMITTEE FOR MANY YEARS,

1623
01:00:33,105 --> 01:00:34,740
THEY HANDED THE GAVEL BACK AND

1624
01:00:34,740 --> 01:00:36,041
FORTH, SHE IS THE RAIRCHGING

1625
01:00:36,041 --> 01:00:36,308
MEMBER.

1626
01:00:36,308 --> 01:00:37,843
WE DON'T KNOW WHAT'S GOING TO

1627
01:00:37,843 --> 01:00:38,777
HAPPEN WITH ELECTIONS OBVIOUSLY

1628
01:00:38,777 --> 01:00:41,680
BUT THEY WILL BE AT THE TOP OF

1629
01:00:41,680 --> 01:00:44,016
THOSE COMMITTEES EITHER IN THE

1630
01:00:44,016 --> 01:00:44,650
MAJORITY OR MINORITY.

1631
01:00:44,650 --> 01:00:45,717
THAT IS REALLY GOOD NEWS EMPLOY

1632
01:00:45,717 --> 01:00:47,052
1 THING I HAVE TALKED TO THE

1633
01:00:47,052 --> 01:00:47,919
BOARD AND AMERICANS ABOUT BEFORE

1634
01:00:47,919 --> 01:00:51,023
IS THIS OLD YOLK IN WASHINGTON

1635
01:00:51,023 --> 01:00:53,158
THERE'S DEMCRATING REPUBLICANS

1636
01:00:53,158 --> 01:00:54,626
AND APPROPRIATORS, THAT IS WHAT

1637
01:00:54,626 --> 01:00:57,362
CHAIRMAN COLE IS TALKING ABOUT

1638
01:00:57,362 --> 01:00:59,665
HERE AND IT IS A REAL BEACON OF

1639
01:00:59,665 --> 01:01:02,434
HOME FOR US RIGHT THOU THAT

1640
01:01:02,434 --> 01:01:03,568
THESE PRAGMATIC THOUGHTFUL

1641
01:01:03,568 --> 01:01:04,636
PEOPLE WHO CARE ABOUT RESEARCH

1642
01:01:04,636 --> 01:01:06,805
ARE IN THESE SPOTS, THIS IS I

1643
01:01:06,805 --> 01:01:08,874
QUOTE THAT DR. RAGHT MILL WHEN I

1644
01:01:08,874 --> 01:01:10,642
SHARED THIS WITH HER A COUPLE

1645
01:01:10,642 --> 01:01:12,177
MONTHS AGO, SHE WAS STRUCK BY IT

1646
01:01:12,177 --> 01:01:14,780
AND ASKED MOOY TO SHARE IT WITH

1647
01:01:14,780 --> 01:01:17,282
YOU AS WELL, THIS COMMENT THAT

1648
01:01:17,282 --> 01:01:18,483
CHAIRMAN COLE MADE THAT

1649
01:01:18,483 --> 01:01:20,085
BIOMEDICAL RESEARCH IS LIKE THE

1650
01:01:20,085 --> 01:01:22,854
MILITARY, YOU CAN'T CREATE IT

1651
01:01:22,854 --> 01:01:24,022
OVER NIGHT, YOU HAVE TO SUSTAIN

1652
01:01:24,022 --> 01:01:26,525
IT OVER TIME EMPLOY NOW THESE

1653
01:01:26,525 --> 01:01:28,327
COMMENTS, YOU HAVE TO READ FOR

1654
01:01:28,327 --> 01:01:29,127
YOURSELF MORE QUICKLY THAN I

1655
01:01:29,127 --> 01:01:32,064
READ THEM TO YOU BUT HE'S QUITE

1656
01:01:32,064 --> 01:01:32,397
PRESSIENT.

1657
01:01:32,397 --> 01:01:34,299
HE MADE THESE COMMENTS IN AN

1658
01:01:34,299 --> 01:01:34,766
INTERVIEW IN 2017.

1659
01:01:34,766 --> 01:01:40,572
SO THIS IS SOMEONE WHO REALLY

1660
01:01:40,572 --> 01:01:42,407
UNDERSTANDS PREPARATION AND THE

1661
01:01:42,407 --> 01:01:45,477
ONLY THING I WILL SAY ABOUT THE

1662
01:01:45,477 --> 01:01:47,546
COVID POLITICAL SITUATION PAST,

1663
01:01:47,546 --> 01:01:49,314
PRESENT AND FUTURE IN TERMS OF

1664
01:01:49,314 --> 01:01:50,482
PERCEPTIONS, THERE ARE MANY

1665
01:01:50,482 --> 01:01:51,316
MEMBERS LIKE CHAIRMAN COAL WHO

1666
01:01:51,316 --> 01:01:52,351
UNDERSTAND THAT THE REASON WE

1667
01:01:52,351 --> 01:01:54,553
WERE ABLE TO DEVELOP A VACCINE

1668
01:01:54,553 --> 01:01:55,587
IN RECORD BREAKING TIME IS

1669
01:01:55,587 --> 01:01:57,155
BECAUSE OF THESE SUSTAINED

1670
01:01:57,155 --> 01:01:59,658
INVESTMENTS AND BECAUSE OF THAT

1671
01:01:59,658 --> 01:02:00,826
PREPARATION AND SO WE ARE

1672
01:02:00,826 --> 01:02:02,527
FORTUNATE TO HAVE SUCH INFORMED

1673
01:02:02,527 --> 01:02:04,429
MEMBERS OF CONGRESS WHO ARE

1674
01:02:04,429 --> 01:02:07,933
WORKING IN NEEZ APPROPRIATIONS

1675
01:02:07,933 --> 01:02:08,734
ISSUES AND THEY'RE MISINFORMED

1676
01:02:08,734 --> 01:02:10,235
BECAUSE OF THE SCIENTISTS, LIKE

1677
01:02:10,235 --> 01:02:11,870
YOURSELF AND THE LEADERS OF NCI

1678
01:02:11,870 --> 01:02:13,905
AND NE H AND OTHER SCIENTISTS

1679
01:02:13,905 --> 01:02:16,975
ACROSS THE GOVERNMENT WHO HAVE

1680
01:02:16,975 --> 01:02:18,410
MADE IT A RORRITY TO TAKE THE

1681
01:02:18,410 --> 01:02:19,444
TIME TO SHOW OUR WORK.

1682
01:02:19,444 --> 01:02:23,548
IT IS NOT OBVIOUS TO A LOT OF

1683
01:02:23,548 --> 01:02:24,716
NONSCIENTISTS WHY THERE'S SO

1684
01:02:24,716 --> 01:02:26,251
MANY NEW TREATMENTS FOR VARIOUS

1685
01:02:26,251 --> 01:02:27,986
TYPES OF CANCER FOR INFECTIOUS

1686
01:02:27,986 --> 01:02:29,788
DISEASES FOR ALL SORTS OF

1687
01:02:29,788 --> 01:02:31,056
AUTOIMMUNE DECS, THIS IS NOT

1688
01:02:31,056 --> 01:02:32,491
OBVIOUS TO THEM, THEY HEAR FROM

1689
01:02:32,491 --> 01:02:33,792
PATIENTS, THEY HEAR FROM

1690
01:02:33,792 --> 01:02:34,559
CLINICIANS, BUT IT'S OUR YOB

1691
01:02:34,559 --> 01:02:36,261
CORPS TO SHOW THEM AND TO HELP

1692
01:02:36,261 --> 01:02:40,499
DRAW THOSE LINES ABOUT

1693
01:02:40,499 --> 01:02:41,833
INVESTMENT AND OUTCOMES.

1694
01:02:41,833 --> 01:02:43,001
THE SENATE APPROPRIATIONS

1695
01:02:43,001 --> 01:02:46,838
COMMITTEE HAD A HEARING ON THE

1696
01:02:46,838 --> 01:02:47,873
NIH FY25 BUDGET REQUEST AT THE

1697
01:02:47,873 --> 01:02:50,542
ENTD OF MAY EMPLOY THE HOUSE

1698
01:02:50,542 --> 01:02:52,110
PROARGZS COMMITTEE DIDN'T HAVE

1699
01:02:52,110 --> 01:02:53,311
TIME, THEY DECIDED TO MOVE

1700
01:02:53,311 --> 01:02:54,679
QUICKLY THROUGH THE BILL ANDS

1701
01:02:54,679 --> 01:02:55,881
GET TO A POINT OF NEGOTIATION,

1702
01:02:55,881 --> 01:02:58,917
SO THERE WAS NOT FOR FY25 A

1703
01:02:58,917 --> 01:02:59,551
TYPICAL HEARING.

1704
01:02:59,551 --> 01:03:00,952
THIS WILL PLAY OUT HOWEVER IT

1705
01:03:00,952 --> 01:03:03,355
DOES WITH NEW LEADERSHIP.

1706
01:03:03,355 --> 01:03:06,324
I EXPECT THAT IN FOR FY26 WE

1707
01:03:06,324 --> 01:03:07,392
WILL PROBABLY RESUME HEARINGS

1708
01:03:07,392 --> 01:03:10,662
BUT IT WILL DEPEND ON THE

1709
01:03:10,662 --> 01:03:15,801
TIMING, DR. RATHMILL,

1710
01:03:15,801 --> 01:03:17,502
DR. BERTAGNOLLI, AND THEIR FIRST

1711
01:03:17,502 --> 01:03:20,572
EXPERIENCES WITH BEING WITNESSES

1712
01:03:20,572 --> 01:03:24,409
ON AN APPROPRIATION HEARING, AND

1713
01:03:24,409 --> 01:03:26,812
OBVIOUSLY DR. BERTAGNOLLI HAD

1714
01:03:26,812 --> 01:03:28,146
HER SENATE CONFIRMATIONS

1715
01:03:28,146 --> 01:03:29,581
HEARINGS, BUT IT WAS A DIFFERENT

1716
01:03:29,581 --> 01:03:29,848
COMMITTEE.

1717
01:03:29,848 --> 01:03:32,050
OUR GROUP DID A GRIT JOB,

1718
01:03:32,050 --> 01:03:32,951
STRONG, POSITIVE HEARING.

1719
01:03:32,951 --> 01:03:34,553
A LOT OF FIRST ANDS SECONDS, I

1720
01:03:34,553 --> 01:03:36,721
WANTED TO POINT THIS OUT SO WE

1721
01:03:36,721 --> 01:03:38,156
HAVE THE SECOND WOMAN DIRECTOR

1722
01:03:38,156 --> 01:03:40,225
OF NCI, WE HAVE THE FIRST WOMAN

1723
01:03:40,225 --> 01:03:42,727
DIRECTOR OF NCI AND THE SECOND

1724
01:03:42,727 --> 01:03:45,897
WOMAN DIRECTOR OF THE NIH.

1725
01:03:45,897 --> 01:03:47,299
AND DR. JEAN MAREFRESH YOUR

1726
01:03:47,299 --> 01:03:48,600
RECOLLECTION RASWRRK ZO IS THE

1727
01:03:48,600 --> 01:03:50,802
FIRST WOMAN TO LEAD THE NIAID.

1728
01:03:50,802 --> 01:03:53,672
AND A LOT OF US WERE REALLY

1729
01:03:53,672 --> 01:03:57,742
HAPPY TO SEE THIS, THE COMMITTEE

1730
01:03:57,742 --> 01:03:58,777
THEY WERE TESTIFYING BEFORE IS

1731
01:03:58,777 --> 01:04:09,287
LED BY THE BIG CHAIR, SENATOR

1732
01:04:10,055 --> 01:04:11,056
PATTY CHERRY, AND COLLEAGUES, SO

1733
01:04:11,056 --> 01:04:13,124
I WANTED TO GET A PICTURE OF

1734
01:04:13,124 --> 01:04:14,526
THESE WOMEN WITH THOSE CHAIRS

1735
01:04:14,526 --> 01:04:17,496
BUT I FELT LIKE IT WOULD BE RUDE

1736
01:04:17,496 --> 01:04:21,433
TO EXCLUDE DR. GIBBONS AND

1737
01:04:21,433 --> 01:04:23,034
DR. HODETH, WHEN ALSO

1738
01:04:23,034 --> 01:04:24,569
ACCOMPANIED OUR 31st TIMERS

1739
01:04:24,569 --> 01:04:34,980
AND DR.  NORA VOLKOW, IS A VERY

1740
01:04:34,980 --> 01:04:36,815
EFFECTIVE WITNESS TO GET PEOPLE

1741
01:04:36,815 --> 01:04:37,749
EXCITED ABOUT BRAIN SCIENCE EVEN

1742
01:04:37,749 --> 01:04:40,218
IF THEY'RE NOT SURE WHAT THEY'RE

1743
01:04:40,218 --> 01:04:41,353
EXCITED ABOUT.

1744
01:04:41,353 --> 01:04:43,188
THE YELLOW IBDICATES WHEN BOTH

1745
01:04:43,188 --> 01:04:45,457
CHAMBERS OF CONGRESS ARE IN

1746
01:04:45,457 --> 01:04:46,958
SESSION, BLUE IS SENATE ONLY AND

1747
01:04:46,958 --> 01:04:48,894
RED IS HOUSE OLD.

1748
01:04:48,894 --> 01:04:53,798
SO HEREY ARE IN THE 12, WE HAVE

1749
01:04:53,798 --> 01:04:55,233
TODAY, TOMORROW AND THE NEXT

1750
01:04:55,233 --> 01:04:55,467
DAY.

1751
01:04:55,467 --> 01:04:57,202
THEN THE HOWES GOES OFF INTO

1752
01:04:57,202 --> 01:04:58,637
RECESS, SO WHAT THE HOUSE IS

1753
01:04:58,637 --> 01:04:59,905
FOCUSING ON IS TRYING TO GET

1754
01:04:59,905 --> 01:05:01,406
THROUGH ALL OF THEIR SPENDING

1755
01:05:01,406 --> 01:05:03,174
BILLS, AND GET THEM MARKED UP BY

1756
01:05:03,174 --> 01:05:05,777
THE END OF JULY.

1757
01:05:05,777 --> 01:05:07,746
WHAT WE'RE LOOKING AT HERE THEN

1758
01:05:07,746 --> 01:05:10,348
IS AN ENTIRE AUGUST OFF AND IN

1759
01:05:10,348 --> 01:05:11,783
SEPTEMBER THERE WILL BE 3 WEEKS,

1760
01:05:11,783 --> 01:05:12,851
I THINK IN SEPTEMBER WE WILL SEE

1761
01:05:12,851 --> 01:05:14,953
IN THE LAST WEEK, CONTINUING

1762
01:05:14,953 --> 01:05:17,355
RESOLUTION TO KEEP THE

1763
01:05:17,355 --> 01:05:18,957
GOVERNMENT FUNDED, OCTOBER, NO

1764
01:05:18,957 --> 01:05:20,358
WORK PLANNED, THIS IS AN

1765
01:05:20,358 --> 01:05:23,094
ELECTION YEAR, AND SO, EVERYONE

1766
01:05:23,094 --> 01:05:25,330
WILL BE BACK CAMPAIGNING,

1767
01:05:25,330 --> 01:05:26,231
BARRING ANY EMERGENCIES THAT

1768
01:05:26,231 --> 01:05:27,766
WOULD REQUIRE A CONGRESS TO COME

1769
01:05:27,766 --> 01:05:31,169
BACK, THIS IS THEIR PLAN, SO,

1770
01:05:31,169 --> 01:05:32,671
THERE IS SOME MUST-PASS

1771
01:05:32,671 --> 01:05:36,274
LEGISLATION THAT HAS TO BE DEALT

1772
01:05:36,274 --> 01:05:37,809
WITH IN THIS SESSION THERE IS

1773
01:05:37,809 --> 01:05:39,578
THE NATIONAL DEFENSE

1774
01:05:39,578 --> 01:05:40,679
AUTHORIZATION ACT, THERE'S THE

1775
01:05:40,679 --> 01:05:42,747
FARM BILL WHICH HAS HAD A LOT OF

1776
01:05:42,747 --> 01:05:44,182
FIT ANDS STARTS OF PROGRESS,

1777
01:05:44,182 --> 01:05:45,317
THAT'S IMPORTANT IT'S DONE BY

1778
01:05:45,317 --> 01:05:47,152
THE END OF THE SEPTEMBER AND

1779
01:05:47,152 --> 01:05:49,054
THERE'S AT LEAST 1 OTHER I CAN'T

1780
01:05:49,054 --> 01:05:49,921
RECALL RIGHT NOW.

1781
01:05:49,921 --> 01:05:52,257
THE GOOD NEWS ABOUT MUST PASS

1782
01:05:52,257 --> 01:05:53,625
LEGISLATION IS THINGS CAN GET A

1783
01:05:53,625 --> 01:05:55,160
RIDE ON MUST PASS LEGISLATION

1784
01:05:55,160 --> 01:05:59,030
AND IT SPURS ANY ACTIVITY.

1785
01:05:59,030 --> 01:06:02,167
I WANTED TO POINT OUT THE LAME

1786
01:06:02,167 --> 01:06:03,802
DUCK CONGRESS, THE LAKE DUCK

1787
01:06:03,802 --> 01:06:05,303
CONGRESS STARTS ON THE 12th

1788
01:06:05,303 --> 01:06:06,605
AND GOES THROUGH DECEMBER.

1789
01:06:06,605 --> 01:06:08,573
CONGRESS WILL NOT LIKELY BE IN

1790
01:06:08,573 --> 01:06:11,042
WASH DURING THE CHRISTMAS WEEK,

1791
01:06:11,042 --> 01:06:12,777
BUT THERE'S NOT A LOT OF TIME IN

1792
01:06:12,777 --> 01:06:14,846
THE LAME DUCK SESSION, SO WHAT

1793
01:06:14,846 --> 01:06:16,715
WILL HAPPEN WITH FY25

1794
01:06:16,715 --> 01:06:17,482
APPROPRIATIONS?

1795
01:06:17,482 --> 01:06:20,819
WE KNOW IT WILL START THE YEAR

1796
01:06:20,819 --> 01:06:23,455
IN A STOP GAP BUT WHERE WILL IT

1797
01:06:23,455 --> 01:06:23,655
END.

1798
01:06:23,655 --> 01:06:25,323
CHAIRMAN COAL SAID THERE WILL BE

1799
01:06:25,323 --> 01:06:27,826
A CR SO I FEEL COMFORTABLE

1800
01:06:27,826 --> 01:06:28,460
SEEING THAT.

1801
01:06:28,460 --> 01:06:30,629
THE OUTCOME OF ELECTIONS WILL

1802
01:06:30,629 --> 01:06:32,564
DETERMINE WHAT GETS DONE IN THE

1803
01:06:32,564 --> 01:06:34,165
LAME DUCK BUT IT IS IMPOSSIBLE

1804
01:06:34,165 --> 01:06:35,867
TO PRO DICT HOW.

1805
01:06:35,867 --> 01:06:39,270
IN BOTH 20 AND 22, ALL 12

1806
01:06:39,270 --> 01:06:40,672
SPENDING BILLS WERE ENACTED

1807
01:06:40,672 --> 01:06:42,707
DURING THE LAME LUCK, SO MAYBE

1808
01:06:42,707 --> 01:06:44,576
THAT TELLS YOU THERE WAS

1809
01:06:44,576 --> 01:06:46,544
MAIORITY CHANGES AND THOSE WHO

1810
01:06:46,544 --> 01:06:48,513
WERE IN THE OUTGOING MAIORITY,

1811
01:06:48,513 --> 01:06:50,782
IT WAS THEIR LAST CHANCE TO

1812
01:06:50,782 --> 01:06:52,283
INFLUENCE SPENDING LEVELS, IN

1813
01:06:52,283 --> 01:06:53,818
2016 AND 18, AND 11 BILLS WERE

1814
01:06:53,818 --> 01:06:55,654
RESPECT TD AFTER THE LAME DUCK,

1815
01:06:55,654 --> 01:06:57,756
SO BY THE NEXT CONGRESS, THE

1816
01:06:57,756 --> 01:07:00,025
118th CONGRESS AND THE END OF

1817
01:07:00,025 --> 01:07:04,896
DECEMBER, SO 119th IS STARTING

1818
01:07:04,896 --> 01:07:05,397
BEGINNING OF JANUARY.

1819
01:07:05,397 --> 01:07:08,133
I HAVE NO IDEA WHAT'S GOING TO

1820
01:07:08,133 --> 01:07:09,668
HAPPEN WITH 24, HERE'S A GRAPH,

1821
01:07:09,668 --> 01:07:12,070
I TRIED TO COME UP WITH SCIENCE

1822
01:07:12,070 --> 01:07:13,204
AND DATA TO SHOW SCIENTISTS AND

1823
01:07:13,204 --> 01:07:18,943
I DON'T THINK A LOT OF PEOPLE--I

1824
01:07:18,943 --> 01:07:21,346
MEAN IT'S A RANDOM PATTERN, SO

1825
01:07:21,346 --> 01:07:24,449
THE BLUE BARS ARE BEFORE THE

1826
01:07:24,449 --> 01:07:25,817
LAME DUCK SESSION, ORANGE IS

1827
01:07:25,817 --> 01:07:27,218
DURING THE LAME DUCK SESSION AND

1828
01:07:27,218 --> 01:07:29,054
GREEN IS AFTER THE LAME DUCK

1829
01:07:29,054 --> 01:07:30,455
SESSION, OTHER THAN THE EXTREMES

1830
01:07:30,455 --> 01:07:32,323
AT BOTH ENDS I CAN'T REALLY

1831
01:07:32,323 --> 01:07:33,158
PREDICT ANYTHING HERE AND GIVEN

1832
01:07:33,158 --> 01:07:36,594
THAT I THINK I WON'T SPEND A LOT

1833
01:07:36,594 --> 01:07:38,463
OF TIME ON THIS BUT IN CASE YOU

1834
01:07:38,463 --> 01:07:40,832
NOTICE THAT THE FIRST COUPLE OF

1835
01:07:40,832 --> 01:07:42,434
COLUMNS UP TO 204 ARE TALLER

1836
01:07:42,434 --> 01:07:45,437
THAN ALL THE SUBSEQUENT 1S THEY

1837
01:07:45,437 --> 01:07:47,739
GOT RID OF 1 OF THE

1838
01:07:47,739 --> 01:07:48,606
SUBCOMMITTEES, THERE USED TO BE

1839
01:07:48,606 --> 01:07:50,375
13 AND NOW THERE ARE 12, THERE

1840
01:07:50,375 --> 01:07:51,543
ARE LEGISLATIVE ISSUES TO WATCH

1841
01:07:51,543 --> 01:07:53,812
AND THIS IS WHY MUST PASS

1842
01:07:53,812 --> 01:07:55,113
LEGISLATION IS A VEHICLE FOR

1843
01:07:55,113 --> 01:07:56,981
THESE PROVISIONS AND I WANT TO

1844
01:07:56,981 --> 01:07:58,583
POINT THAT OUT.

1845
01:07:58,583 --> 01:07:59,317
TELEHEALTH, WE REALIZE HOW

1846
01:07:59,317 --> 01:08:00,985
IMPORTANT THAT IT IS TO

1847
01:08:00,985 --> 01:08:02,520
EFFICIENCY, TO COST SAVING

1848
01:08:02,520 --> 01:08:04,589
CONVENIENCE FOR PATIENT ANDS

1849
01:08:04,589 --> 01:08:06,191
SOME IMOGRAPHIC AREAS IT'S

1850
01:08:06,191 --> 01:08:07,158
ESSENTIAL TO PROVIDE

1851
01:08:07,158 --> 01:08:07,859
OPPORTUNITIES, CONGRESS IS

1852
01:08:07,859 --> 01:08:09,794
PAYING A LOT OF ATTENTION TO

1853
01:08:09,794 --> 01:08:11,463
THAT, THE EXTEBDERS THAT WERE

1854
01:08:11,463 --> 01:08:13,798
PUT IN PLACE DURING THE PUBLIC

1855
01:08:13,798 --> 01:08:15,066
HEALTH EMERGENCY EXPIRED AND

1856
01:08:15,066 --> 01:08:18,169
THEY'VE BEEN EXTENDED BUT NOT

1857
01:08:18,169 --> 01:08:19,104
PERMANENTLY AND THOSE HAVE BE

1858
01:08:19,104 --> 01:08:21,206
DEALT WITH MY THE END OF THE

1859
01:08:21,206 --> 01:08:21,406
YEAR.

1860
01:08:21,406 --> 01:08:22,841
DRUG SHORTAGES IS SOMETHING THAT

1861
01:08:22,841 --> 01:08:26,444
OBVIOUSLY HAS BEEN A BIG CONCERN

1862
01:08:26,444 --> 01:08:27,612
OVER MULTIPLE YEARS AND

1863
01:08:27,612 --> 01:08:29,614
DIFFERENT CYCLES OF SHORTAGES,

1864
01:08:29,614 --> 01:08:31,750
HHS RELEASED A WHITE PAPER ON

1865
01:08:31,750 --> 01:08:33,017
THIS, CONGRESS CONDEMN PLATING

1866
01:08:33,017 --> 01:08:35,453
SEVERAL SORTS OF LEGISLATIVE

1867
01:08:35,453 --> 01:08:38,323
SOLUTIONS, WE MIGHT SEE SOME

1868
01:08:38,323 --> 01:08:39,224
LEGISLATION ABOUT THAT, MOVING,

1869
01:08:39,224 --> 01:08:41,459
THERE'S ATTENTION TO CLENICAL

1870
01:08:41,459 --> 01:08:47,165
TRIALS, POINTS OF ACCESS, AI IS

1871
01:08:47,165 --> 01:08:50,168
OF COURSE OF INTEREST, LOTS OF

1872
01:08:50,168 --> 01:08:52,604
CONCERNS ABOUT ITS POTENTIAL FOR

1873
01:08:52,604 --> 01:08:54,339
ABUSE AND POTENTIAL FOR REAL

1874
01:08:54,339 --> 01:08:55,573
IMPROVEMENT, NOOH H SPECIFIC

1875
01:08:55,573 --> 01:08:57,275
LEGISLATION, I JUST PUT THIS ON

1876
01:08:57,275 --> 01:09:00,345
AS A CATEGORY BECAUSE YOU MAY

1877
01:09:00,345 --> 01:09:04,215
HAVE HEARD ABOUT SOME OF THE

1878
01:09:04,215 --> 01:09:05,250
CURES ACT, HERE'S 200,

1879
01:09:05,250 --> 01:09:08,286
[INDISCERNIBLE] IN HOUSE AND A

1880
01:09:08,286 --> 01:09:09,420
REPUBLICAN COUNTERPART LARRY

1881
01:09:09,420 --> 01:09:11,055
[INDISCERNIBLE] FROM INDIANA

1882
01:09:11,055 --> 01:09:12,891
THEY WERE TRYING TO THINK ABOUT

1883
01:09:12,891 --> 01:09:14,626
CREATIVELY WHAT CAN THEY DO THAT

1884
01:09:14,626 --> 01:09:17,362
MIGHT BE HELPFUL TO BIOMEDICAL

1885
01:09:17,362 --> 01:09:18,663
RESEARCH AGENCIES ACROSS THE

1886
01:09:18,663 --> 01:09:21,633
BOARD AND REGULATORY AGENCIES IN

1887
01:09:21,633 --> 01:09:23,034
THE SENATE, SENATOR BILL KASES

1888
01:09:23,034 --> 01:09:24,068
EDUCATIONALY OF LOUISIANA, IS

1889
01:09:24,068 --> 01:09:27,238
LOOKING AT SOME ISSUES ABOUT NIH

1890
01:09:27,238 --> 01:09:30,542
AND HOPING TO REALLY I THINK BE

1891
01:09:30,542 --> 01:09:31,876
A HELPING FACTOR, POSITIVE

1892
01:09:31,876 --> 01:09:34,612
FACTOR IF TRYING TO LOOK AT

1893
01:09:34,612 --> 01:09:35,680
REAUTHORIZATION IN WAYS THAT

1894
01:09:35,680 --> 01:09:36,714
MAYBE WE CAN IMPROVE

1895
01:09:36,714 --> 01:09:38,449
TRANSPARENCY SO THOSE ARE ALL

1896
01:09:38,449 --> 01:09:39,918
MORE NASCENT EFFORTS AT THIS

1897
01:09:39,918 --> 01:09:41,953
POINT, SO WE WILL BE WATCHING

1898
01:09:41,953 --> 01:09:44,689
THOSE, IT MAY BE THE 119th

1899
01:09:44,689 --> 01:09:45,690
CONGRESS WHERE WE SEE ACTIVITY

1900
01:09:45,690 --> 01:09:47,826
THERE, AND I WANT TO HIGHLIGHT

1901
01:09:47,826 --> 01:09:49,027
AND RECOGNIZE SOME REAL EFFORTS

1902
01:09:49,027 --> 01:09:51,329
PUT FORTH BY A LOT OF PEOPLE

1903
01:09:51,329 --> 01:09:52,130
WITHIN THE CANCER RESEARCH

1904
01:09:52,130 --> 01:09:53,798
COMMUNITY, MANY OF YOU, MANY OF

1905
01:09:53,798 --> 01:09:55,333
YOUR COLLEAGUES WHO HAVE

1906
01:09:55,333 --> 01:09:57,202
PARTICIPATED IN THINGS LIKE

1907
01:09:57,202 --> 01:09:58,136
COLLABORATIVE HILL DAYS, IT'S

1908
01:09:58,136 --> 01:10:00,672
JUST A PICTURE OF FROM THIS MOST

1909
01:10:00,672 --> 01:10:03,575
RECENT HILL DAYS THAT ACI AND

1910
01:10:03,575 --> 01:10:04,843
ACR COLLABORATED ON, THERE WAS

1911
01:10:04,843 --> 01:10:06,845
ALSO THE RELEASE OF HEALTH

1912
01:10:06,845 --> 01:10:08,179
DISPARITIES REPORT THAT

1913
01:10:08,179 --> 01:10:09,380
DR. SONIA SPRING FIELD WAS

1914
01:10:09,380 --> 01:10:11,249
HEAVILY INVOF INDEED AND

1915
01:10:11,249 --> 01:10:12,884
REPRESENTED NCI AT A

1916
01:10:12,884 --> 01:10:13,618
CONGRESSIONAL BRIEFINGS BEFORE

1917
01:10:13,618 --> 01:10:16,754
THIS HILL DAY THAT WAS REALLY

1918
01:10:16,754 --> 01:10:19,290
WELL ATTENDED AND HERE'S ANOTHER

1919
01:10:19,290 --> 01:10:21,159
1, GROUPS OF ASCO MEMBERS AND

1920
01:10:21,159 --> 01:10:23,194
DR. REFRESH YOUR RECOLLECTION

1921
01:10:23,194 --> 01:10:24,762
ATHMILL HAS BEEN SPENDING A LOT

1922
01:10:24,762 --> 01:10:26,798
OF TIME ENGEAJING IN THESE

1923
01:10:26,798 --> 01:10:30,168
EVENTS WITH OUR TEAM AND OUR

1924
01:10:30,168 --> 01:10:31,402
ADVOCACY RELATIONS COLLEAGUES.

1925
01:10:31,402 --> 01:10:32,770
IT'S IMPORTANT FOR THESE LEADERS

1926
01:10:32,770 --> 01:10:35,006
TO BE ABLE TO MEET THE LEADERS

1927
01:10:35,006 --> 01:10:36,007
OF THESE AGENCIES AND

1928
01:10:36,007 --> 01:10:36,474
EN--STRATEGIESITUTES.

1929
01:10:36,474 --> 01:10:37,942
THIS IS JUST A PICTURE I WANTED

1930
01:10:37,942 --> 01:10:42,680
TO SHOW YOU OF DR. RATHMILL

1931
01:10:42,680 --> 01:10:43,748
MEETING WITH SENATE

1932
01:10:43,748 --> 01:10:45,483
APPROPRIATORS AND SHE HAD

1933
01:10:45,483 --> 01:10:46,217
ALREADY WORKING WITH SENATOR

1934
01:10:46,217 --> 01:10:48,486
BALD WIN AND I WANTED TO LIE

1935
01:10:48,486 --> 01:10:52,223
THIS, SHE MET WITH CONGRESSMAN

1936
01:10:52,223 --> 01:10:53,658
JIM MORELLI, DEMCRATE FROM THE

1937
01:10:53,658 --> 01:10:54,726
ROUGH ATOM CHESTER NEW YORK AND

1938
01:10:54,726 --> 01:10:56,594
IT WAS A VERY POSITIVE MEET XG I

1939
01:10:56,594 --> 01:10:58,029
PULLED OUT A PIECE OF THE TWEET

1940
01:10:58,029 --> 01:11:00,298
THAT HIS OFFICE PUT OUT AFTER

1941
01:11:00,298 --> 01:11:03,067
THE MEETING, HE LOST HIS

1942
01:11:03,067 --> 01:11:04,502
DAUGHTER TO TRIPLE NEG5 BREAST

1943
01:11:04,502 --> 01:11:06,137
CANCER IN HER 30 ANDS IT WAS A

1944
01:11:06,137 --> 01:11:07,372
VERY POSITIVE KREVERGZ AND HE

1945
01:11:07,372 --> 01:11:08,840
SAYS THE FIGHT AGAINST CANCER IS

1946
01:11:08,840 --> 01:11:10,909
DEEPLY PERSONAL FOR ME, THAT'S

1947
01:11:10,909 --> 01:11:18,650
WHEN HE MEANS, BUT CANCER SUCH

1948
01:11:18,650 --> 01:11:21,152
AS EVERYONE IS FOR EVERYONE, AND

1949
01:11:21,152 --> 01:11:22,854
DEMON TRAIT THE VALUE OF WHAT

1950
01:11:22,854 --> 01:11:23,888
THESE INVESTMENTS ARE AND WHEN

1951
01:11:23,888 --> 01:11:24,956
YOU'RE ASKED TO MEET WITH

1952
01:11:24,956 --> 01:11:26,691
MEMBERS AND SHARE YOUR EXPERTISE

1953
01:11:26,691 --> 01:11:28,192
WHETHER IT'S ABOUT LEGISLATION

1954
01:11:28,192 --> 01:11:29,827
OR JUST TO HELP THEM WITH AN

1955
01:11:29,827 --> 01:11:32,130
ISSUE THEY MIGHT BE HAVING WITH

1956
01:11:32,130 --> 01:11:33,765
THEIR FAMILY OR CONSTITUENT,

1957
01:11:33,765 --> 01:11:35,500
PLEASE DO THAT AND PLEASE, YOU

1958
01:11:35,500 --> 01:11:36,935
KNOW LET US KNOW IF THERE ARE

1959
01:11:36,935 --> 01:11:38,469
WAYS WE CAN BE HELPFUL TO YOU

1960
01:11:38,469 --> 01:11:40,772
BECAUSE THIS IS A COMMUNITY

1961
01:11:40,772 --> 01:11:41,005
EFFORT.

1962
01:11:41,005 --> 01:11:42,340
EVERYONE HAS A ROLE IN TRYING TO

1963
01:11:42,340 --> 01:11:44,208
BRING THIS MESSAGE AND MAKE SURE

1964
01:11:44,208 --> 01:11:45,243
CONGRESS REALLY HAPPENEDS WHAT

1965
01:11:45,243 --> 01:11:47,078
THEY'RE GETTING FOR THEIR

1966
01:11:47,078 --> 01:11:47,445
INVESTMENT.

1967
01:11:47,445 --> 01:11:51,883
I DON'T KNOW IF WE HAVE TIME TO

1968
01:11:51,883 --> 01:11:54,619
TAKE QUESTIONS, DOCTOR, YOU TELL

1969
01:11:54,619 --> 01:11:55,887
ME?

1970
01:11:55,887 --> 01:11:57,055
>> ANY QUESTIONS IN.

1971
01:11:57,055 --> 01:11:58,156
>> MARRIAN CORONADO FROM
THE

1972
01:11:58,156 --> 01:11:59,791
UNIVERSITY OF ARIZONA, THANK YOU

1973
01:11:59,791 --> 01:12:00,858
FOR THIS UPDATE, IT'S ALWAYS

1974
01:12:00,858 --> 01:12:02,493
SOMETHING I LOOK FORWARD TO AT

1975
01:12:02,493 --> 01:12:04,696
THESE MEETINGS, I WANT TO ASK

1976
01:12:04,696 --> 01:12:07,765
ABOUT MOON SHOT, SO I KNOW THAT

1977
01:12:07,765 --> 01:12:10,702
IT DID GET INCLUDED IN THIS

1978
01:12:10,702 --> 01:12:12,437
YEAR'S BUDGET IT SOUNDS LIKE

1979
01:12:12,437 --> 01:12:14,439
THERE'S A POSSIBILITY THAT IT

1980
01:12:14,439 --> 01:12:16,274
GETS INCLUDED IN FUTURE, HOW

1981
01:12:16,274 --> 01:12:18,276
SHOULD WE BE THINKING ABOUT MOON

1982
01:12:18,276 --> 01:12:19,677
SHOT AND ANSWERING PEOPLE'S

1983
01:12:19,677 --> 01:12:19,944
QUESTIONS.

1984
01:12:19,944 --> 01:12:25,416
>> IT'S A GOOD QUESTION.

1985
01:12:25,416 --> 01:12:27,819
SO THE CANCER MOONSHOT THAT WAS

1986
01:12:27,819 --> 01:12:30,321
DRAFTED AND FUNDED THROUGH THE

1987
01:12:30,321 --> 01:12:32,390
21st CENTURY CURES ACT, THAT

1988
01:12:32,390 --> 01:12:34,025
WAS A 7 YEAR STREAM OF FUND

1989
01:12:34,025 --> 01:12:37,628
THAGOREAN KIND OF WENT LIKE

1990
01:12:37,628 --> 01:12:40,164
THIS, CONGRESS DID IN FY20  WE

1991
01:12:40,164 --> 01:12:44,502
HAD A DROP IN FUNDING FROM

1992
01:12:44,502 --> 01:12:45,436
400 MILLION TO 492 MILLION, THAT

1993
01:12:45,436 --> 01:12:47,038
YEAR THEY WERE ABLE TO FILL IN

1994
01:12:47,038 --> 01:12:50,274
THAT GAP THROUGH OUR BASE BUDGET

1995
01:12:50,274 --> 01:12:52,210
WHICH WAS REALLY WONDERFUL AND

1996
01:12:52,210 --> 01:12:55,079
WE WERE HOPEFUL BUT PRACTICALLY

1997
01:12:55,079 --> 01:12:56,347
REALIZE THEY JUST DIDN'T HAVE

1998
01:12:56,347 --> 01:12:59,450
THE ALLOCATION TO DO THAT FOR

1999
01:12:59,450 --> 01:12:59,784
FOOTWORK Y24.

2000
01:12:59,784 --> 01:13:00,885
I CERTAINLY THINK THERE WAS THE

2001
01:13:00,885 --> 01:13:03,054
INTEREST IN DOING IT.

2002
01:13:03,054 --> 01:13:04,689
WHAT I THINK YOU MIGHT BE

2003
01:13:04,689 --> 01:13:09,293
REFERRING TO IS THERE'S

2004
01:13:09,293 --> 01:13:11,496
PROPOSALS FOR MANDATORY FUNDING

2005
01:13:11,496 --> 01:13:16,567
FOR 1.4 FOR 8 BILLION FOR THE

2006
01:13:16,567 --> 01:13:17,502
CANCER MOONSHOT.

2007
01:13:17,502 --> 01:13:19,504
THAT IS INTENDED TO SUPPORT THIS

2008
01:13:19,504 --> 01:13:20,905
REALLY BROAD EFFORT TO ACHIEVE

2009
01:13:20,905 --> 01:13:22,640
THE GOALS OF DECREASING

2010
01:13:22,640 --> 01:13:26,411
MORTALITY BY 50% IN 25 YEARS.

2011
01:13:26,411 --> 01:13:30,214
THAT REQUIRES A REALLY

2012
01:13:30,214 --> 01:13:30,715
SIGNIFICANT INVESTMENT,

2013
01:13:30,715 --> 01:13:32,050
MANDATORY FUND SUGGEST

2014
01:13:32,050 --> 01:13:33,451
NONAPOPTOTIC PROVIDED THROUGH

2015
01:13:33,451 --> 01:13:34,385
THE APPROPRIATE ALLOCATIONS,

2016
01:13:34,385 --> 01:13:36,120
IT'S PROVIDED THROUGH

2017
01:13:36,120 --> 01:13:38,790
LEGISLATION THAT'S AUTHORIZING

2018
01:13:38,790 --> 01:13:42,927
LEGISLATION, SO IT DOES SIGNIFY

2019
01:13:42,927 --> 01:13:44,962
AN IMPORTANT PRIORITY FOR THE

2020
01:13:44,962 --> 01:13:45,897
ADMINITRATION AND SOMETHING

2021
01:13:45,897 --> 01:13:47,198
THOSE GOALS ARE AS REAL TO US AS

2022
01:13:47,198 --> 01:13:48,833
THEY WOULD BE WITH ANOTHER PIECE

2023
01:13:48,833 --> 01:13:55,006
OF LEGISLATION, THE ISSUE IS

2024
01:13:55,006 --> 01:13:57,208
REALLY WOULD CONGRESS BE ABLE TO

2025
01:13:57,208 --> 01:13:59,177
IDENTIFY SOURCES OF MANTIS

2026
01:13:59,177 --> 01:14:00,778
SHRIMPATORY FUNDING IN A

2027
01:14:00,778 --> 01:14:02,880
DIFFICULT TIME, BUDGET CAP YEAR,

2028
01:14:02,880 --> 01:14:06,050
SO 24 AND 25 ARE PROBABLY REALLY

2029
01:14:06,050 --> 01:14:07,085
CHALLENGING YEARS IF ARE THAT TO

2030
01:14:07,085 --> 01:14:08,453
HAPPEN EMPLOY TIMES IT TAKES

2031
01:14:08,453 --> 01:14:09,654
MORE THAN 1 ATTEMPT TO GET

2032
01:14:09,654 --> 01:14:13,224
SOMETHING LIKE THIS MOVING.

2033
01:14:13,224 --> 01:14:15,093
AND I HAVE BEEN SURPRISED BY A

2034
01:14:15,093 --> 01:14:16,260
LOT OF THINGS CONGRESS HAS BEEN

2035
01:14:16,260 --> 01:14:18,229
ABLE TO DO WHEN THERE'S ENOUGH

2036
01:14:18,229 --> 01:14:19,730
MOMENTUM BUT I THINK WHAT WE

2037
01:14:19,730 --> 01:14:21,365
NEED TO DO IS SORT OF STAY

2038
01:14:21,365 --> 01:14:22,900
FOCUSED ON GOALS AND WHAT WE CAN

2039
01:14:22,900 --> 01:14:24,869
DO WITH OUR EXISTING ALLOCATIONS

2040
01:14:24,869 --> 01:14:26,971
BECAUSE A LOT OF THOSE THINGS

2041
01:14:26,971 --> 01:14:29,340
ARE WORK WE'RE DOING THROUGHOUT

2042
01:14:29,340 --> 01:14:31,209
MANY PARTS OF OUR PORTFOLIOS AND

2043
01:14:31,209 --> 01:14:33,978
I THINK THAT THIS COULD BE

2044
01:14:33,978 --> 01:14:35,580
SOMETHING DR. RATHMILL MAY HAVE

2045
01:14:35,580 --> 01:14:37,215
A COMMENT ON NOW OR AT THE PRAIK

2046
01:14:37,215 --> 01:14:39,283
EMPLOY SO I THINK WE ARE JUST

2047
01:14:39,283 --> 01:14:41,986
STAYING TRUE TO THOSE GOALS AND

2048
01:14:41,986 --> 01:14:43,187
BEING VERY HOPEFUL ABOUT THE

2049
01:14:43,187 --> 01:14:43,421
FUTURE.

2050
01:14:43,421 --> 01:14:45,723
WE ONLY HAVE TIME FOR 1 MORE

2051
01:14:45,723 --> 01:14:49,260
QUESTION AND I WOULD SAY THAT WE

2052
01:14:49,260 --> 01:14:52,797
HAVE ADDITIONAL QUESTIONS, DO IT

2053
01:14:52,797 --> 01:14:53,197
DURING THE BREAK.

2054
01:14:53,197 --> 01:14:54,899
>> THANK YOU VERY MUCH.

2055
01:14:54,899 --> 01:15:01,038
SO HEARING A LOT FROM CAPITOL

2056
01:15:01,038 --> 01:15:02,540
HILL FOR POTENTIAL 2.0 CURES

2057
01:15:02,540 --> 01:15:03,808
ACT.

2058
01:15:03,808 --> 01:15:05,143
IS THAT REAL?

2059
01:15:05,143 --> 01:15:07,678
WILL THERE BE ANY APPROPRIATIONS

2060
01:15:07,678 --> 01:15:09,147
ASSOCIATE WIDE THAT POINT

2061
01:15:09,147 --> 01:15:12,950
VERSUS, THEY DID A LOT FOR US

2062
01:15:12,950 --> 01:15:13,551
AND FDA--

2063
01:15:13,551 --> 01:15:15,486
>> SO THERE WAS A QUESTION
FOR

2064
01:15:15,486 --> 01:15:16,554
INFORMATION PUT OUT JUST LAST

2065
01:15:16,554 --> 01:15:18,823
WEEK I THINK FROM CONGRESS

2066
01:15:18,823 --> 01:15:19,557
[INDISCERNIBLE], AND CONGRESSMAN

2067
01:15:19,557 --> 01:15:20,158
[INDISCERNIBLE].

2068
01:15:20,158 --> 01:15:24,996
THEY ARE LOOKING TO SEE WHAT IN

2069
01:15:24,996 --> 01:15:28,966
LEGISLATION FOR CURES 2-POINT 0

2070
01:15:28,966 --> 01:15:30,601
OUT OF LAST LEGISLATION, ARE

2071
01:15:30,601 --> 01:15:33,571
THERE OTHER THINGS THAT CAN BE

2072
01:15:33,571 --> 01:15:34,639
DONE, APPROPRIATORS AND

2073
01:15:34,639 --> 01:15:36,174
AUTHORIZERS ARE LOOKING AT WHAT

2074
01:15:36,174 --> 01:15:37,942
CAN WE DO THAT IT'S HELPFUL TO

2075
01:15:37,942 --> 01:15:39,844
AGENCIES TO HELP ACHIEVE THESE

2076
01:15:39,844 --> 01:15:41,012
GOALS, FUNDING ASIDE, THAT'S

2077
01:15:41,012 --> 01:15:44,315
FUND SUGGEST 1 PART, BUT THERE'S

2078
01:15:44,315 --> 01:15:45,950
ALSO OTHER OPPORTUNITIES, OTHER

2079
01:15:45,950 --> 01:15:46,784
FLEXIBILITIES, OTHER THINGS WE

2080
01:15:46,784 --> 01:15:48,286
CAN DO AND THOSE ARE SOME OF THE

2081
01:15:48,286 --> 01:15:49,353
QUESTIONS THAT WE HAVE GOTTEN

2082
01:15:49,353 --> 01:15:52,356
AND THAT HAVE COME TO DR. RARK

2083
01:15:52,356 --> 01:15:54,258
THMILL AS SHE'S TAKEN OVER AT

2084
01:15:54,258 --> 01:15:55,860
NCI, SO I DON'T KNOW WHAT'S

2085
01:15:55,860 --> 01:15:56,827
GOING TO HAPPEN WITH THAT, I

2086
01:15:56,827 --> 01:15:58,229
DON'T THINK THAT WOULD BE

2087
01:15:58,229 --> 01:16:03,334
SOMETHING WE WOULD EXPECT IN SAY

2088
01:16:03,334 --> 01:16:05,269
THE FIRST 3 MONTHS OF THE NEXT

2089
01:16:05,269 --> 01:16:07,238
CONGRESS AND I THINK WE'RE

2090
01:16:07,238 --> 01:16:08,506
LOOKING AT THE 119th AND WE

2091
01:16:08,506 --> 01:16:11,976
WILL HAVE TO SEE HOW THE NEWS--

2092
01:16:11,976 --> 01:16:14,278
>> LAST THING WE HAVE A
PLANNING

2093
01:16:14,278 --> 01:16:15,713
AND BUDGETING COMMITTEE, IT'S A

2094
01:16:15,713 --> 01:16:16,447
VERY EXCITING COMMITTEE IF YOU

2095
01:16:16,447 --> 01:16:18,182
WANT TO YOIN, IF YOU HAVEN'T

2096
01:16:18,182 --> 01:16:20,818
JOINED YET, WE COMMITTED

2097
01:16:20,818 --> 01:16:22,086
DR. RATHMILL TO HELP IN ANY WAY

2098
01:16:22,086 --> 01:16:22,687
WE CAN.

2099
01:16:22,687 --> 01:16:25,022
WE HAVE LARGE SUMS OF MONEY.

2100
01:16:25,022 --> 01:16:27,458
>> CURES IS A VERY BIG,
THEIR

2101
01:16:27,458 --> 01:16:29,360
FOCUS IS VERY BROAD, SO NIH IS

2102
01:16:29,360 --> 01:16:32,029
PART OF IT, BUT NOT ALL OF IT.

2103
01:16:32,029 --> 01:16:33,764
SO, THERE WILL BE MORE ON THAT

2104
01:16:33,764 --> 01:16:35,066
TO COME, I THINK.

2105
01:16:35,066 --> 01:16:36,133
THANK YOU VERY MUCH.

2106
01:16:36,133 --> 01:16:46,510
NTHANK YOU VERY MUCH.

2107
01:16:49,580 --> 01:16:52,016
>> SO MOVING ON WE HAVE

2108
01:16:52,016 --> 01:16:55,720
RECOGNITION OF RETIRING BSA

2109
01:16:55,720 --> 01:16:57,755
MEMBERS.

2110
01:16:57,755 --> 01:16:58,823
DR. RATHMELL.

2111
01:16:58,823 --> 01:17:01,692
>> SO WE HAVE 2 BSA
MEMBERS WHO

2112
01:17:01,692 --> 01:17:03,427
ARE RETIRING IN THIS CYCLE,

2113
01:17:03,427 --> 01:17:06,831
NEITHER ARE HERE TODAY, SO I'LL

2114
01:17:06,831 --> 01:17:10,568
BE FAIRLY BRIEF BUT WE DO HAVE

2115
01:17:10,568 --> 01:17:14,505
DR. SYLVIA [INDISCERNIBLE] UP

2116
01:17:14,505 --> 01:17:16,374
HERE, SO, SHE HAS BEEN A BIG

2117
01:17:16,374 --> 01:17:18,042
CHAMPION FOR OUR TALK ABOUT--I

2118
01:17:18,042 --> 01:17:25,416
LOST HER, I WILL LOOK AT YOU

2119
01:17:25,416 --> 01:17:28,019
GUYS, DATA AI, SCIENCE, SO

2120
01:17:28,019 --> 01:17:31,789
SYLVIA IS THE DIRECTOR FOR THE

2121
01:17:31,789 --> 01:17:33,658
AI AND ASSOCIATE STANFORD CANCER

2122
01:17:33,658 --> 01:17:35,259
EN--STRATEGIESITUTE AND BEEN A

2123
01:17:35,259 --> 01:17:37,094
MARVELOUS BOARD MEMBER AND

2124
01:17:37,094 --> 01:17:38,162
ENJOYED SERVING ALONGSIDE HER

2125
01:17:38,162 --> 01:17:44,302
AND ON THIS COMMITTEE AND

2126
01:17:44,302 --> 01:17:45,369
RECOGNITION OF SERVICE, SYLVIA I

2127
01:17:45,369 --> 01:17:47,338
DON'T KNOW IF YOU CAN SEE, YOU

2128
01:17:47,338 --> 01:17:49,540
GET A NICE PLAQUE FOR YOUR WALL

2129
01:17:49,540 --> 01:17:59,917
AS FAR AS OUR FOREVER

2130
01:18:02,320 --> 01:18:03,254
GRATEFULNESS.

2131
01:18:03,254 --> 01:18:05,956
AND OUR OTHER MEMBER RETIRING

2132
01:18:05,956 --> 01:18:07,792
WHO CAN'T JOIN TODAY IS BOB

2133
01:18:07,792 --> 01:18:08,726
[INDISCERNIBLE], HE IS VICE

2134
01:18:08,726 --> 01:18:09,827
PRESIDENT OF CANCER PROGRAMSA

2135
01:18:09,827 --> 01:18:14,498
THE YRT OF PENS OPINION HE'S'

2136
01:18:14,498 --> 01:18:15,199
RENOWNED INVESTIGATOR IN

2137
01:18:15,199 --> 01:18:16,000
IMMUNOTHERAPY AND TRANSLATIONAL

2138
01:18:16,000 --> 01:18:17,101
RESEARCH AND GUIDING OUR EFFORTS

2139
01:18:17,101 --> 01:18:21,505
IN THAT SPACE SO REALLY GRATEFUL

2140
01:18:21,505 --> 01:18:23,407
FOR HIS EFFORTS AS WELL, SO

2141
01:18:23,407 --> 01:18:29,914
THANKS VERY MUCH.

2142
01:18:29,914 --> 01:18:32,483
>> OKAY, NEXT ON OUR
AGENDA

2143
01:18:32,483 --> 01:18:34,852
EXCITING PRESENTATION ON

2144
01:18:34,852 --> 01:18:39,023
HIGHLIGHTS OF THE CENTER FOR

2145
01:18:39,023 --> 01:18:39,957
CANCER DEGOMMICS THAT WILL BE

2146
01:18:39,957 --> 01:18:42,626
BROUGHT TO US BY DR. LOU STOUT

2147
01:18:42,626 --> 01:18:45,129
WHO SERVES AS DIRECTOR FOR THE

2148
01:18:45,129 --> 01:18:47,565
CENTER FOR CANCER GENOMICS, AND

2149
01:18:47,565 --> 01:18:51,635
CANCER RESEARCH AND ALEX

2150
01:18:51,635 --> 01:18:52,536
[INDISCERNIBLE], PROFESSOR

2151
01:18:52,536 --> 01:18:53,704
INSTITUTE PER MEDICAL

2152
01:18:53,704 --> 01:18:55,439
ENGINEERING AND SCIENCE AND

2153
01:18:55,439 --> 01:18:57,041
DEPARTMENT OF CHEMISTRY AND

2154
01:18:57,041 --> 01:19:00,344
DIRECTOR FOR HEGHT INNOVATION

2155
01:19:00,344 --> 01:19:02,413
CLUB.

2156
01:19:02,413 --> 01:19:02,580
LOU?

2157
01:19:02,580 --> 01:19:03,080
NTHANKS, JOHN.

2158
01:19:03,080 --> 01:19:06,517
SO WHEN KIM ASKED MOOY TO DO

2159
01:19:06,517 --> 01:19:13,324
THIS, KNOWING HER PREDELICATION

2160
01:19:13,324 --> 01:19:14,759
FOR PRESENTATIONS I COULDN'T

2161
01:19:14,759 --> 01:19:15,826
POSSIBLY TELL YOU ABOUT ALL

2162
01:19:15,826 --> 01:19:18,229
WE'RE DOING IN THE CENTER FOR

2163
01:19:18,229 --> 01:19:19,530
CANCER GENOMICS, WE'RE THE

2164
01:19:19,530 --> 01:19:22,833
STEWARDS OF THE TCGA COLLECTION

2165
01:19:22,833 --> 01:19:25,002
OF TUMORS, WE CONTINUE TO WORK

2166
01:19:25,002 --> 01:19:25,936
ON THAT.

2167
01:19:25,936 --> 01:19:31,008
WE RUN THE NCI GENOMIC DATA

2168
01:19:31,008 --> 01:19:33,411
COMMONS THAT HAS A HUNDRED

2169
01:19:33,411 --> 01:19:34,145
THOUSAND UNIQUE VISITORS EVERY

2170
01:19:34,145 --> 01:19:35,579
MONTH BUT I'M GOING TO TELL YOU

2171
01:19:35,579 --> 01:19:37,815
TODAY ABOUT A RESOURCE THAT

2172
01:19:37,815 --> 01:19:39,116
WE'VE DEVELOPED THAT YOU MAY OR

2173
01:19:39,116 --> 01:19:45,456
MAY NOT HAVE HEARD OF, A NEXT

2174
01:19:45,456 --> 01:19:47,258
GENERATION CANCER MODELS AND

2175
01:19:47,258 --> 01:19:51,462
THEN END WITH WHAT WE MIGHT DO

2176
01:19:51,462 --> 01:19:53,664
WITH ALL THESE.

2177
01:19:53,664 --> 01:19:55,800
SO AS CANCER BIOLOGISTS, WE WE

2178
01:19:55,800 --> 01:19:57,468
NOW HAVE A NEW FRAMEWORK TO

2179
01:19:57,468 --> 01:20:00,438
THINK ABOUT CANCER COMING OUT OF

2180
01:20:00,438 --> 01:20:04,942
TCGA AND MANY OTHER EFFORTS IN

2181
01:20:04,942 --> 01:20:06,710
TERMS OF SUBTYPES OF CANCER AND

2182
01:20:06,710 --> 01:20:10,080
IN PARTICULAR DRIVERS OF CANCER

2183
01:20:10,080 --> 01:20:11,949
THAT COME FROM THAT, AND THE

2184
01:20:11,949 --> 01:20:13,584
NEXT UP FOR CANCER BIOLOGIST IS

2185
01:20:13,584 --> 01:20:17,021
TO HAVE A MODEL.

2186
01:20:17,021 --> 01:20:21,525
NO MODEL, NO DISCOVERIES, AND

2187
01:20:21,525 --> 01:20:23,494
WAWE WOULD DO WITH THIS MODEL IS

2188
01:20:23,494 --> 01:20:25,329
A LOT OF THE THOUGHTS ARE WHAT I

2189
01:20:25,329 --> 01:20:29,567
DO IN MY LAB ON LYMPHOMA BUT

2190
01:20:29,567 --> 01:20:31,435
GENERALLY ARK PLICCABLE WE WILL

2191
01:20:31,435 --> 01:20:33,370
TAKE A FUNCTIONAL APPROACH AND A

2192
01:20:33,370 --> 01:20:34,305
FUNCTIONAL DENATIONAL LIBRARY OF

2193
01:20:34,305 --> 01:20:35,840
MEDICINICS APPROACH WOULD NOT BE

2194
01:20:35,840 --> 01:20:37,608
TO FOCUS ON 1 YEEN AND ALL THE

2195
01:20:37,608 --> 01:20:41,879
YEENS WE USE RNAi CRISPR,

2196
01:20:41,879 --> 01:20:44,949
SMALL MOLECULES OR LIBRARIES OF

2197
01:20:44,949 --> 01:20:45,883
MUTANT OPEN READING FRAMES AND

2198
01:20:45,883 --> 01:20:49,420
WE WOULD USE THIS TO COVER

2199
01:20:49,420 --> 01:20:50,955
ESSENTIAL AND POTENTIALLY

2200
01:20:50,955 --> 01:20:51,889
DRUGGABLE PATHWAYS THAT WE WOULD

2201
01:20:51,889 --> 01:20:56,594
HOPE TO LEAD TO COMBINATION

2202
01:20:56,594 --> 01:20:57,294
THERAPIES OF CANCER.

2203
01:20:57,294 --> 01:21:00,264
SO THINKING ABOUT THESE MODELS

2204
01:21:00,264 --> 01:21:03,601
THEN, THERE ARE DEFICIENCIES IN

2205
01:21:03,601 --> 01:21:04,902
OUR CURRENT COLLECTION.

2206
01:21:04,902 --> 01:21:06,637
THEY TYPICALLY WE DO NOT HAVE

2207
01:21:06,637 --> 01:21:08,472
THE PRIMARY TUMOR FROM WHICH THE

2208
01:21:08,472 --> 01:21:09,874
MODEL WAS DEVELOPED, SO WE DON'T

2209
01:21:09,874 --> 01:21:12,977
KNOW IF IT'S DRIFTED OR

2210
01:21:12,977 --> 01:21:14,812
OTHERWISE QUITE DIFFERENT.

2211
01:21:14,812 --> 01:21:16,146
THERE'S USUALLY NO CLINICALLAN

2212
01:21:16,146 --> 01:21:17,248
OITATION ASSOCIATED WITH THE

2213
01:21:17,248 --> 01:21:17,581
MODEL.

2214
01:21:17,581 --> 01:21:20,951
WE DON'T KNOW HOW THE PATIENT

2215
01:21:20,951 --> 01:21:21,685
RESPONDED TO THERAPY.

2216
01:21:21,685 --> 01:21:25,856
THERE IS AS YOU KNOW, THERE ARE

2217
01:21:25,856 --> 01:21:29,793
COMMON RECURRENT DRIVER

2218
01:21:29,793 --> 01:21:31,061
MUTATIONS AND THERE ARE LESS

2219
01:21:31,061 --> 01:21:33,464
COMMON 1S AND FOR MANY OF THE

2220
01:21:33,464 --> 01:21:35,199
LESS COMMON MUTATIONS WE MAY NOT

2221
01:21:35,199 --> 01:21:40,237
HAVE ANY EXISTING MODELS IN THE

2222
01:21:40,237 --> 01:21:41,906
UNIVERSE TO TO STUDY THAT WHICH

2223
01:21:41,906 --> 01:21:43,173
IS CLINICALLY IMPORTANT FOR THE

2224
01:21:43,173 --> 01:21:45,209
PATIENT WHO HAS THAT TUMOR

2225
01:21:45,209 --> 01:21:54,151
DRIVEN BY THAT RARE EVENT

2226
01:21:54,151 --> 01:21:55,886
THERE'S QUITE A BIT OF RARE

2227
01:21:55,886 --> 01:21:57,555
CANCER TYPES, DIFFERENT TYPES OF

2228
01:21:57,555 --> 01:21:59,857
SARCOMA FOR EXAMPLE, WE MAY MOT

2229
01:21:59,857 --> 01:22:02,993
HAVE A SINGLE MODEL OR VERY

2230
01:22:02,993 --> 01:22:03,928
UNDERREPRESENTED SET OF MODELS

2231
01:22:03,928 --> 01:22:05,462
AND FINALLY WE DONE KNOW WHETHER

2232
01:22:05,462 --> 01:22:09,199
THE MODELS WE HAVE RACAPITTULATE

2233
01:22:09,199 --> 01:22:10,267
BOTH THE PHENOTYPIC VARIATION

2234
01:22:10,267 --> 01:22:13,003
THAT IS A HUGH MAN TUMOR AS

2235
01:22:13,003 --> 01:22:13,737
LOS ANGELES AT SUBCLONAL

2236
01:22:13,737 --> 01:22:21,378
VARIATION THAT IS IN THE TUMORS

2237
01:22:21,378 --> 01:22:24,014
SO THE GOAL WAS TO CREATE A NEW

2238
01:22:24,014 --> 01:22:24,748
NEXT GENERATION CANCER MODELS

2239
01:22:24,748 --> 01:22:27,618
THAT WOULD HAVE FULL GENOMIC AND

2240
01:22:27,618 --> 01:22:29,420
CLINICAL CHARACTERIZATION AND

2241
01:22:29,420 --> 01:22:36,327
THIS IDEA CAME TO  ME AT AN ACR

2242
01:22:36,327 --> 01:22:38,495
MEETING 2015, 14--I CAN'T

2243
01:22:38,495 --> 01:22:42,733
REMEMBER BUT THE SPEAKER I DO

2244
01:22:42,733 --> 01:22:46,236
REMEMBER IT'S HANZ CLAYBURRS AND

2245
01:22:46,236 --> 01:22:49,006
HE TOLD ME ABOUT HIS NEW

2246
01:22:49,006 --> 01:22:50,274
ORGANOID TECHNOLOGY, I AND I

2247
01:22:50,274 --> 01:22:53,277
HEARD IF TR THE FIRST TIME AND I

2248
01:22:53,277 --> 01:22:56,914
WAS EXCITED AND --I PITCHED IT

2249
01:22:56,914 --> 01:22:58,082
TO HAROLD VARMIS AND HE SAID GO

2250
01:22:58,082 --> 01:22:59,717
FOR IT AND WE HAVE LAUNCHED THEN

2251
01:22:59,717 --> 01:23:03,087
AND CARRIED OUT THIS HUMAN

2252
01:23:03,087 --> 01:23:11,028
CANCER MODELS INITIATIVE HCMI

2253
01:23:11,028 --> 01:23:12,997
AND IN THIS WE USED ALL THESE

2254
01:23:12,997 --> 01:23:17,401
NEW METHODS THAT WE GENERATED

2255
01:23:17,401 --> 01:23:17,868
ORGANOIDS, NEUROFEARS,

2256
01:23:17,868 --> 01:23:18,602
ADDITIONALLY REPROGRAM CELLS AND

2257
01:23:18,602 --> 01:23:20,804
THEN WE DISCOVERED IN THE

2258
01:23:20,804 --> 01:23:24,842
PROCESS THAT YOU CAN MIX AND

2259
01:23:24,842 --> 01:23:26,110
MATCH FORMULATIONS AND SOMETIMES

2260
01:23:26,110 --> 01:23:28,012
GET CERTAIN THINGS TO GROW IN

2261
01:23:28,012 --> 01:23:30,080
THE LABORATORY THAT YOU WOULDN'T

2262
01:23:30,080 --> 01:23:37,354
OTHERWISE, AND SO ALL THESE

2263
01:23:37,354 --> 01:23:39,223
MODELS THEN WOULD COME ALL RIGHT

2264
01:23:39,223 --> 01:23:43,427
ANNOTATED WITH WHOLE GENOME

2265
01:23:43,427 --> 01:23:44,828
SEQUENCING, RNA-SEQ AND

2266
01:23:44,828 --> 01:23:46,096
METHODALATION ANALYSIS AND

2267
01:23:46,096 --> 01:23:47,097
IMPORTANTLY ANOTHER DIFFERENCE

2268
01:23:47,097 --> 01:23:50,067
IS THAT THEY WERE ALL COLLECTED

2269
01:23:50,067 --> 01:23:56,040
IN A PERSPECTIVE WAY WITH

2270
01:23:56,040 --> 01:23:58,809
INFORMED CONSENT AND WE HAD

2271
01:23:58,809 --> 01:24:00,310
STANDARDIZED CASE REPORTS AND

2272
01:24:00,310 --> 01:24:01,278
ALSO HAD DEMOGRAPHICS BUT ALSO

2273
01:24:01,278 --> 01:24:02,579
HAVE RESPONSE TO THE PATIENT TO

2274
01:24:02,579 --> 01:24:05,115
THE TREATMENT THEY RECEIVED RIDE

2275
01:24:05,115 --> 01:24:06,617
AFTER THAT BIOPSIES WAS TAKEN

2276
01:24:06,617 --> 01:24:08,619
AND OUR MEDIAN FOLLOW UP IS 1

2277
01:24:08,619 --> 01:24:15,793
AND HALF YEARS SO ALL OF THIS IS

2278
01:24:15,793 --> 01:24:17,461
A PACKAGE THAT COMES WITH THESE

2279
01:24:17,461 --> 01:24:19,997
MODELS SO WHAT WE DID AS NCI IS

2280
01:24:19,997 --> 01:24:21,799
WE SET UP SEVERAL SITES AROUND

2281
01:24:21,799 --> 01:24:23,333
THE COUNTRY AND OUR GOAL WAS TO

2282
01:24:23,333 --> 01:24:25,436
MAKE A THOUSAND HUMAN CANCER

2283
01:24:25,436 --> 01:24:25,669
MODELS.

2284
01:24:25,669 --> 01:24:26,870
WE EVAPORATE QUITE GOTTEN THERE

2285
01:24:26,870 --> 01:24:30,274
YET, AND THEN WE WOULD BANK

2286
01:24:30,274 --> 01:24:32,342
THESE CELL LINES, WE TURN THE

2287
01:24:32,342 --> 01:24:36,213
CELL LINES INTO DATA, AND WE

2288
01:24:36,213 --> 01:24:37,381
HAVE SEQUENCING NOT JUST OF THE

2289
01:24:37,381 --> 01:24:44,154
CELL LINE BUT ALSO THE PRIMARY

2290
01:24:44,154 --> 01:24:45,322
FROM THE SAME CLINICAL PATIENT

2291
01:24:45,322 --> 01:24:46,490
AND THEN THE CLINICAL DATA WOULD

2292
01:24:46,490 --> 01:24:49,493
GO TOGETHER AND THIS WOULD BE

2293
01:24:49,493 --> 01:24:50,394
DISTRIBUTED RESEARCHERS THROUGH

2294
01:24:50,394 --> 01:24:57,868
A PARTNER WHICH IS ATKRRK CWHICH

2295
01:24:57,868 --> 01:25:01,538
IS 1 OF THE MOST TRUSTED

2296
01:25:01,538 --> 01:25:02,740
PROVIDERS OF QC'D CELL LINES IN

2297
01:25:02,740 --> 01:25:04,508
THE WORLD AND I USE THEM ALL THE

2298
01:25:04,508 --> 01:25:05,809
TIME IN MY OWN RESEARCH.

2299
01:25:05,809 --> 01:25:14,218
SO HERE ARE SOME OF OUR CANCER

2300
01:25:14,218 --> 01:25:15,719
MODEL DEVELOPMENT CENTERS CHIEF

2301
01:25:15,719 --> 01:25:18,322
INITIALLY WAS THE BROAD

2302
01:25:18,322 --> 01:25:21,125
INSTITUTE AT COLD HARBOR WITH

2303
01:25:21,125 --> 01:25:23,327
DANA-FARBER AND WE ADDED ON

2304
01:25:23,327 --> 01:25:24,962
STANFORD AND CORNELL AND

2305
01:25:24,962 --> 01:25:25,896
PARTNERSHIP WITH THE UNIVERSITY

2306
01:25:25,896 --> 01:25:27,197
OF RONA THAT WAS DOING SOME OF

2307
01:25:27,197 --> 01:25:31,502
THIS AND THEN I HEARD THAT THE

2308
01:25:31,502 --> 01:25:34,238
SANGER INSTITUTE WAS DOING

2309
01:25:34,238 --> 01:25:36,006
REALLY THE SAME INITIATIVE AND

2310
01:25:36,006 --> 01:25:40,377
SO WE PARTNERED THEN IN AN

2311
01:25:40,377 --> 01:25:41,211
INTERNATIONAL COLLABORATION AND

2312
01:25:41,211 --> 01:25:42,846
BROUGHT THEIR MODELS IN AND THEN

2313
01:25:42,846 --> 01:25:44,715
ALL THESE MODELS ARE PROFILED IN

2314
01:25:44,715 --> 01:25:46,550
THE UNIFORM WAY THROUGH

2315
01:25:46,550 --> 01:25:51,522
CONTRACKS THAT WE MANAGE IN THE

2316
01:25:51,522 --> 01:25:53,123
CENTER FOR SEQUENCING AT THE

2317
01:25:53,123 --> 01:25:58,829
BROAD INSTITUTE AT UNC AND

2318
01:25:58,829 --> 01:25:59,963
BIOSPECIMEN REPOSITORY AT

2319
01:25:59,963 --> 01:26:01,031
NATIONWIDE CHILDREN'S HOSPITAL

2320
01:26:01,031 --> 01:26:02,633
AND FINALLY THE MANAGEMENT AND

2321
01:26:02,633 --> 01:26:05,502
DATA ARE COORDINATED AT THE NCI

2322
01:26:05,502 --> 01:26:06,870
IME NATIONAL LIBRARY OF

2323
01:26:06,870 --> 01:26:08,639
MEDICINIC DATA COMMONS AT ATCC,

2324
01:26:08,639 --> 01:26:13,076
AND WE'VE HAD A LOT OF HELP FROM

2325
01:26:13,076 --> 01:26:15,846
THE FREDERICK NATIONAL LABS AND

2326
01:26:15,846 --> 01:26:18,048
THE IMS FOR CLINICAL DATA

2327
01:26:18,048 --> 01:26:20,984
CURATION, SO SO FAR WE MADE 743

2328
01:26:20,984 --> 01:26:25,355
MODELS AND 307 OF THEM HAVE

2329
01:26:25,355 --> 01:26:28,025
ALREADY BEEN LAUNCHED THROUGH

2330
01:26:28,025 --> 01:26:31,595
ATCC, CAN YOU BUY THEM A LITTLE

2331
01:26:31,595 --> 01:26:32,763
INSIDER TIP, DON'T GET STICKER

2332
01:26:32,763 --> 01:26:35,232
SHOCK WHEN YOU GO TO THE ATKRRK

2333
01:26:35,232 --> 01:26:40,838
C WEBSITE, IT WILL LOOK REALLY

2334
01:26:40,838 --> 01:26:41,638
EXPENSIVE, THEY--I CAN'T MAKE

2335
01:26:41,638 --> 01:26:45,008
THEM BUJ OFF THIS, THE PRICE FOR

2336
01:26:45,008 --> 01:26:45,843
ACADEMICS IS LESS THAN HALF OF

2337
01:26:45,843 --> 01:26:48,045
WHAT YOU WILL SEE, SO, BUT THEY

2338
01:26:48,045 --> 01:26:49,479
DON'T WANT TO ADVERTISE THAT,

2339
01:26:49,479 --> 01:26:54,017
SO, HERE I AM ON NATIONAL

2340
01:26:54,017 --> 01:26:59,089
TV--NO, BUT LETTING THEM KNOW

2341
01:26:59,089 --> 01:27:00,591
THEIR BUSINESS SECRETS.

2342
01:27:00,591 --> 01:27:02,893
SO OUR MODELS, WE HAVE A LOT OF

2343
01:27:02,893 --> 01:27:06,129
MODELS FROM THE COMMON TYPE OF

2344
01:27:06,129 --> 01:27:10,267
CANCER, BRAIN CANCER, TBLI O

2345
01:27:10,267 --> 01:27:12,636
BLASTOMAS, ESPECIALLY PANCREAS,

2346
01:27:12,636 --> 01:27:16,807
A LOT OF GASTRO-ESOPHAGEAL

2347
01:27:16,807 --> 01:27:18,809
TUMORS AND THEN A LONG TILE OF

2348
01:27:18,809 --> 01:27:20,811
SOME VERY RARE TYPES OF CANCER

2349
01:27:20,811 --> 01:27:22,813
THAT WE HAVE NEW MODELS, TIMES

2350
01:27:22,813 --> 01:27:25,883
THE FIRST MODEL, THE FIRST

2351
01:27:25,883 --> 01:27:29,319
MODELS OF ANCHLIO IMMUNO BLASTIC

2352
01:27:29,319 --> 01:27:30,921
T-CELL LYMPHOMA FOR EXAMPLE, NO

2353
01:27:30,921 --> 01:27:31,655
MODEL EXISTED.

2354
01:27:31,655 --> 01:27:32,322
WE CHARACTERIZE THE IME NATIONAL

2355
01:27:32,322 --> 01:27:34,458
LIBRARY OF MEDICINICS AND HERE

2356
01:27:34,458 --> 01:27:38,061
JUST SHOWING THAT WE HAVE THE

2357
01:27:38,061 --> 01:27:40,898
COMMON DRIVER ALTERATIONS AT THE

2358
01:27:40,898 --> 01:27:43,867
GENETIC LEVEL AND WE'VE ALSO

2359
01:27:43,867 --> 01:27:46,036
LOOKED AT THE TRANSCRIPTOMICS,

2360
01:27:46,036 --> 01:27:50,240
AND HERE IS THE DISPLAYED IN A

2361
01:27:50,240 --> 01:27:51,074
UNAP PROJECTION, THE YEEN

2362
01:27:51,074 --> 01:27:56,446
EXPRESSION FROM SORT OF A

2363
01:27:56,446 --> 01:27:59,116
SCAFFOLD SHALL WE SAY OF TCGA

2364
01:27:59,116 --> 01:28:01,985
SAMPLES AS WELL AS THE EXISTING

2365
01:28:01,985 --> 01:28:04,087
CCLE SET OF CELL LINES AND ON TO

2366
01:28:04,087 --> 01:28:09,226
THE SCAFFOLD WE LAYER, THE HCMI

2367
01:28:09,226 --> 01:28:11,795
TUMORS AND THE HCMI MODELS, AND

2368
01:28:11,795 --> 01:28:14,665
SO WHAT I WANT TO EMPHASIZE IS

2369
01:28:14,665 --> 01:28:17,200
THAT IN SOME CASES FOR EXAMPLE,

2370
01:28:17,200 --> 01:28:22,706
IN THE GBM SPACE,EUR NEW MODELS,

2371
01:28:22,706 --> 01:28:27,010
THE HCMI MODELS ARE IN THE LARM

2372
01:28:27,010 --> 01:28:30,113
CLOUD OF TCGA TUMORS THAT ARE

2373
01:28:30,113 --> 01:28:32,316
GBMs, WHEREAS THE PREVIOUS

2374
01:28:32,316 --> 01:28:34,451
CCLE MODELS ARE OFF BY THEIR

2375
01:28:34,451 --> 01:28:38,655
LONESOME IN A LITTLE SPACE SHOWN

2376
01:28:38,655 --> 01:28:38,956
BELOW.

2377
01:28:38,956 --> 01:28:41,058
SO MAYBE THESE ARE SOMEWHAT

2378
01:28:41,058 --> 01:28:44,061
BETTER MODELS OF GBM WORK THAT

2379
01:28:44,061 --> 01:28:45,195
WILL BE NEEDED.

2380
01:28:45,195 --> 01:28:49,733
NOW I WILL TURN IN THE SECOND

2381
01:28:49,733 --> 01:28:53,370
FEW MINUTES, TO HOW WE MIGHT USE

2382
01:28:53,370 --> 01:28:56,340
THESE MODELS, AND NOW THINK

2383
01:28:56,340 --> 01:29:05,048
ABOUT NEXT GENERATION CANCER

2384
01:29:05,048 --> 01:29:06,216
SIGNALING NETWORKS.

2385
01:29:06,216 --> 01:29:08,285
AND PREDICTIVE CANCER

2386
01:29:08,285 --> 01:29:08,652
THERAPEUTICS.

2387
01:29:08,652 --> 01:29:11,621
SO LAST NIGHT, I SAID OKAY,

2388
01:29:11,621 --> 01:29:13,457
WHO'S MY AUDIENCE HERE AND I

2389
01:29:13,457 --> 01:29:15,892
LOOK AT THE ROSTER AND I SEE

2390
01:29:15,892 --> 01:29:17,294
TREY [INDISCERNIBLE] IN THE

2391
01:29:17,294 --> 01:29:18,829
AUDIENCE AND A LOT OF WHAT I

2392
01:29:18,829 --> 01:29:20,797
WILL TELL YOU HE CAN BE GIVING

2393
01:29:20,797 --> 01:29:25,369
THIS TALK BETTER THAN I, BUT

2394
01:29:25,369 --> 01:29:33,643
NONETHELESS, MAYBE WE GET A

2395
01:29:33,643 --> 01:29:34,411
QUESTION FROM TREY.

2396
01:29:34,411 --> 01:29:37,080
SO THE PROBLEM, THE PROBLEM IS

2397
01:29:37,080 --> 01:29:38,915
THAT OF COURSE MONOTHERAPY, YOU

2398
01:29:38,915 --> 01:29:41,118
HAVE GREAT TARGETED DRUGS THANKS

2399
01:29:41,118 --> 01:29:42,652
TO THE PHARMACEUTICAL INDUSTRY

2400
01:29:42,652 --> 01:29:43,854
BUT AS MONOTHERAPY, THEY ARE A

2401
01:29:43,854 --> 01:29:46,056
LITTLE BIT OF SUCCESS,

2402
01:29:46,056 --> 01:29:47,090
RESISTANCE EMERGING ALMOST

2403
01:29:47,090 --> 01:29:50,794
IMMEDIATELY IN SOME CASES, WE DO

2404
01:29:50,794 --> 01:29:55,365
HAVE COMBINATION THERAPIES, SOME

2405
01:29:55,365 --> 01:29:57,100
OF THEM EFFECTIVE BUT THEY'RE

2406
01:29:57,100 --> 01:29:58,869
LARGELY, I WOULDN'T SAY

2407
01:29:58,869 --> 01:29:59,836
EXCLUSIVELY BUT LARGELY IM 

2408
01:29:59,836 --> 01:30:03,040
PERICAL AND NOT BASED ON A DEEP

2409
01:30:03,040 --> 01:30:04,741
KNOWLEDGE OF NETWORK REGULATORY

2410
01:30:04,741 --> 01:30:07,477
NETWORKS IN PARTICULAR CANCER

2411
01:30:07,477 --> 01:30:07,744
TYPES.

2412
01:30:07,744 --> 01:30:12,783
AND IN PARTICULAR OUR CURRENT

2413
01:30:12,783 --> 01:30:14,885
IDEAS ARE SORT OF VANILLA, THAT

2414
01:30:14,885 --> 01:30:19,389
IS THEY'RE THE SAME NETWORK

2415
01:30:19,389 --> 01:30:20,891
EVERYWHERE, WHEREAS WE KNOW THAT

2416
01:30:20,891 --> 01:30:22,225
EACH CANCER TYPE COMING FROM A

2417
01:30:22,225 --> 01:30:23,360
DIFFERENT TYPE OF PRIMARY CELL

2418
01:30:23,360 --> 01:30:25,128
WILL HAVE A DIFFERENT

2419
01:30:25,128 --> 01:30:27,030
EPIIMENETTIC SET POINT THAT WILL

2420
01:30:27,030 --> 01:30:28,799
CHANGE ITS CANCER NETWORK, THERE

2421
01:30:28,799 --> 01:30:31,568
WILL BE AN INFLUENCE OF

2422
01:30:31,568 --> 01:30:32,736
ONCOGENIC ALTASD RAYINGS ON

2423
01:30:32,736 --> 01:30:36,373
THOSE NETWORK ANDS THEN THERE'S

2424
01:30:36,373 --> 01:30:38,642
A NETWORK REDUNDANCY FEEDBACK

2425
01:30:38,642 --> 01:30:39,810
CIRCUITS AND JUST GENERAL

2426
01:30:39,810 --> 01:30:42,079
COMPLEXITY THAT HAS NOT BEEN

2427
01:30:42,079 --> 01:30:43,046
DEALT WITH.

2428
01:30:43,046 --> 01:30:45,549
FURTHER MORE, OUR MODELS

2429
01:30:45,549 --> 01:30:47,050
TYPICALLY ARE DESCRIPTIVE BUT

2430
01:30:47,050 --> 01:30:50,954
THEY HAVEN'T BEEN USED EXCEPT IN

2431
01:30:50,954 --> 01:30:55,392
SOME CASES TO BE PREDICTIVE AND

2432
01:30:55,392 --> 01:30:58,228
ARE GENERALLY STATIC BUT NOT

2433
01:30:58,228 --> 01:31:00,030
DYNAMIC OVER TIME.

2434
01:31:00,030 --> 01:31:02,666
SO HOW DO WE APPROACH THIS, JUST

2435
01:31:02,666 --> 01:31:04,734
IN GRAPHICAL TERMS AND REALLY I

2436
01:31:04,734 --> 01:31:06,870
TOOK A LOT OF SLIDES OUT FOR

2437
01:31:06,870 --> 01:31:14,077
TIME, THIS IS--THIS IS THE BCR

2438
01:31:14,077 --> 01:31:16,713
ABLE, TARGETED BIOMAT NIB SLIDE.

2439
01:31:16,713 --> 01:31:18,915
REALLY OVERSOLD HOW EASY IT WAS

2440
01:31:18,915 --> 01:31:20,984
TO DO PRECISION MEDICINE.

2441
01:31:20,984 --> 01:31:24,621
MOSTLY OUR CANCERS HAVE MORE

2442
01:31:24,621 --> 01:31:25,255
COMPLICATED CIRCUITS AND THEN

2443
01:31:25,255 --> 01:31:28,391
WHEN YOU TREAT WITH MONOTHERAPY,

2444
01:31:28,391 --> 01:31:30,527
THE TUMOR KEEPS ON GROWING AND

2445
01:31:30,527 --> 01:31:32,829
SO WE WOULD LIKE TO UNDERSTAND

2446
01:31:32,829 --> 01:31:35,232
THESE NETWORKS WELL ENOUGH SO WE

2447
01:31:35,232 --> 01:31:38,969
CAN ACTUALLY PROPOSE AND TEST

2448
01:31:38,969 --> 01:31:40,470
COMBINATIONS THAT WILL HIT ALL

2449
01:31:40,470 --> 01:31:44,541
THOSE NODES AND LEAD TO CELL

2450
01:31:44,541 --> 01:31:44,741
DEATH.

2451
01:31:44,741 --> 01:31:48,078
SO WHAT I'M GOING TO SHOW YOU

2452
01:31:48,078 --> 01:31:51,715
NOW IS AN UNFUNDED MANDATE, NOT

2453
01:31:51,715 --> 01:31:53,650
OCCURRED PRIORITY OF THE NCI AND

2454
01:31:53,650 --> 01:31:54,951
ALL SORTS OF DISCLAIMERS, BUT

2455
01:31:54,951 --> 01:31:57,687
SOMETHING THAT I HAVE PITCHED

2456
01:31:57,687 --> 01:32:02,392
BEFORE AND WE A REALLY NICE

2457
01:32:02,392 --> 01:32:04,194
OUTSIDE INVESTIGATORS COME IN

2458
01:32:04,194 --> 01:32:08,064
FOR A RETREAT ON THIS AND WAS

2459
01:32:08,064 --> 01:32:09,933
WELL RECEIVED SO FAR LACK OF A

2460
01:32:09,933 --> 01:32:13,637
BETTER WORD, I WILL CALL IT A

2461
01:32:13,637 --> 01:32:15,505
FUNCTIONAL TCGA INITIATIVE AND

2462
01:32:15,505 --> 01:32:17,340
THE TCGA REFERS TO IT BEING A

2463
01:32:17,340 --> 01:32:20,310
TEAM SCIENCE ACTIVITY IN TERMS

2464
01:32:20,310 --> 01:32:24,614
OF A COLLECTION OF DATA ACTIVITY

2465
01:32:24,614 --> 01:32:25,982
AND AN IMMEDIATE DISTRIBUTION OF

2466
01:32:25,982 --> 01:32:27,951
SAID DATA TO THE COMMUNITY.

2467
01:32:27,951 --> 01:32:29,252
THERE MIGHT BE A COORDINATING

2468
01:32:29,252 --> 01:32:31,888
CENTER THAT WOULD PULL TOGETHER

2469
01:32:31,888 --> 01:32:32,956
ALL SORTS OF [INDISCERNIBLE],

2470
01:32:32,956 --> 01:32:35,859
AND THESE WOULD BE SMALL

2471
01:32:35,859 --> 01:32:37,827
MOLECULES THAT WOULD GET

2472
01:32:37,827 --> 01:32:41,631
PARTICULAR ESSENTIAL CANCER

2473
01:32:41,631 --> 01:32:42,232
PATHWAYS, CRISPR REAGENTS, ET

2474
01:32:42,232 --> 01:32:44,334
CETERA AND THEN THERE MIGHT

2475
01:32:44,334 --> 01:32:45,402
BE--AND THEN THERE'S FOR

2476
01:32:45,402 --> 01:32:49,406
EXAMPLE, THE COLLECTION OF HCMI

2477
01:32:49,406 --> 01:32:49,639
MODELS.

2478
01:32:49,639 --> 01:32:51,608
WE WOULD ENVISION SETTING UP

2479
01:32:51,608 --> 01:32:52,776
HUBS OF EXCELLENCE AROUND THE

2480
01:32:52,776 --> 01:32:55,912
COUNTRY THAT WERE GOOD AT CRISPR

2481
01:32:55,912 --> 01:33:01,418
TYPE FUNCTION WILLA,AINAL SIS,

2482
01:33:01,418 --> 01:33:02,185
PROTEOMIC HUBS DOING

2483
01:33:02,185 --> 01:33:03,954
PROTEIN-PROTEIN INTERACTION AND

2484
01:33:03,954 --> 01:33:06,523
PROTEIN MODIFICATION, SINGLE

2485
01:33:06,523 --> 01:33:09,492
CELL HUBS, CHEMICAL BIOLOGY HUBS

2486
01:33:09,492 --> 01:33:14,297
TO PROBE THEM IN UNIQUE WAYS AND

2487
01:33:14,297 --> 01:33:15,298
IMPORTANTLY CELL BIOLOGICAL

2488
01:33:15,298 --> 01:33:16,633
HUBS, WHERE ARE THINGS TAKING

2489
01:33:16,633 --> 01:33:19,236
PLACE IN THE CELL.

2490
01:33:19,236 --> 01:33:20,770
AND WE WOULD IMAGINE THAT 1 OF

2491
01:33:20,770 --> 01:33:23,373
THE MAIN ACTIVITIES OF THIS

2492
01:33:23,373 --> 01:33:28,211
WOULD BE A COORDINATED SET OF

2493
01:33:28,211 --> 01:33:29,713
EXPERIMENTS IN WHICH A

2494
01:33:29,713 --> 01:33:32,349
PREAIMREED UPON SET OF MODELS

2495
01:33:32,349 --> 01:33:35,118
WITH AN AIM IN SIGHT WOULD BE

2496
01:33:35,118 --> 01:33:37,754
PERTURBED WITH A SET OF  

2497
01:33:37,754 --> 01:33:39,556
PERTERB GENERATEDS AND DATA THEN

2498
01:33:39,556 --> 01:33:41,758
WOULD BE CLEBBED IN

2499
01:33:41,758 --> 01:33:42,659
MULTIDIMENSIONAL FASHION OVER A

2500
01:33:42,659 --> 01:33:47,597
TIME COURSE AND THEN FED INTO

2501
01:33:47,597 --> 01:33:48,465
SOME COMPUTATIONAL HUBS.

2502
01:33:48,465 --> 01:33:50,033
SO THE WHOLE GOAL IS TO MAKE

2503
01:33:50,033 --> 01:33:54,604
THESE NEXT GENERATION MODELS, OF

2504
01:33:54,604 --> 01:33:55,639
CANCER REGULATORY NETWORKS, STEP

2505
01:33:55,639 --> 01:33:57,540
0 REALLY WOULD BE TO TAKE THAT

2506
01:33:57,540 --> 01:33:59,142
PRIMARY DATA AND IMMEDIATELY

2507
01:33:59,142 --> 01:34:01,311
DISTRIBUTE IT TO THE COMMUNITY,

2508
01:34:01,311 --> 01:34:03,146
SO WE COULD CROWD SOURCE.

2509
01:34:03,146 --> 01:34:06,449
EVERYBODY GETS TO PLAY WITH THIS

2510
01:34:06,449 --> 01:34:08,985
DATA BUT THEN WE MAY WORK WITH

2511
01:34:08,985 --> 01:34:10,520
OUR COMPUTATIONAL HUBS TO COME

2512
01:34:10,520 --> 01:34:12,489
UP WITH DETAILED WIRING DIAGRAMS

2513
01:34:12,489 --> 01:34:14,891
OF IRPT STELLAR PATHWAYS AND

2514
01:34:14,891 --> 01:34:18,428
ESPECIAL LE HOW CANCER'S CELL

2515
01:34:18,428 --> 01:34:22,132
TYPE DIFFERENTIATION OF ORCHG O

2516
01:34:22,132 --> 01:34:24,134
GENIC ALTERATIONS CHANGES THOSE

2517
01:34:24,134 --> 01:34:25,502
REGULATORY STRUCTURES.

2518
01:34:25,502 --> 01:34:27,937
WE COULD EASILY FIND, I THINK

2519
01:34:27,937 --> 01:34:28,571
SYNTHETIC LETHAL RELATIONSHIPS

2520
01:34:28,571 --> 01:34:32,108
WITH SOME OF OUR EXISTING DRUGS

2521
01:34:32,108 --> 01:34:35,011
SUCH THAT A PATIENT WITH A

2522
01:34:35,011 --> 01:34:35,945
PARTICULAR GENETIC ABNORMALITY

2523
01:34:35,945 --> 01:34:42,686
WOULD BE PARTICULARLY SENSITIVE

2524
01:34:42,686 --> 01:34:43,119
TO AN INTERVENTION.

2525
01:34:43,119 --> 01:34:44,788
WE WOULD HAVE NEW TARGETS AND

2526
01:34:44,788 --> 01:34:47,324
THESE TARGETS MIGHT LEAD TO

2527
01:34:47,324 --> 01:34:49,826
COMBINATION THERAPIES AND I

2528
01:34:49,826 --> 01:34:52,495
WOULD ENVISION EVEN AS FAR AS

2529
01:34:52,495 --> 01:34:53,163
TESTING THESE COMBINATION

2530
01:34:53,163 --> 01:34:59,135
THERAPIES WITH A LOT OF DATA

2531
01:34:59,135 --> 01:35:02,939
COLLECTION IN PHASE 1 CLINICAL

2532
01:35:02,939 --> 01:35:04,407
TRIALS, SO, AGAIN, I DID CLEAR

2533
01:35:04,407 --> 01:35:06,810
THIS WITH KIM AND SHE SAID IT'S

2534
01:35:06,810 --> 01:35:09,646
FINE AS LONG AS EVERYBODY KNOWS

2535
01:35:09,646 --> 01:35:13,650
THAT THIS IS FOR DISCUSSION SO

2536
01:35:13,650 --> 01:35:21,691
I'M HAPPY TO HAVE ANY QUESTIONS 

2537
01:35:21,691 --> 01:35:24,828
THANKS.

2538
01:35:24,828 --> 01:35:26,363
>> THANKS, LOU. 

2539
01:35:26,363 --> 01:35:27,030
>> CHAIR'S PREROGATIVE.

2540
01:35:27,030 --> 01:35:27,297
[LAUGHTER]

2541
01:35:27,297 --> 01:35:29,366
O LET'S DO THE NEXT SPEAKER,

2542
01:35:29,366 --> 01:35:31,768
THERE'S ANOTHER SPEAKER,

2543
01:35:31,768 --> 01:35:32,335
CORRECT?

2544
01:35:32,335 --> 01:35:37,407
>> LET'S DO THAT FIRST. 

2545
01:35:37,407 --> 01:35:39,943
>> SORRY ABOUT THAT.

2546
01:35:39,943 --> 01:35:42,345
SO ALEX SHALEK, WHO YOU MAY WELL

2547
01:35:42,345 --> 01:35:44,547
KNOW IS SOMEONE WE FUNDED FOR

2548
01:35:44,547 --> 01:35:47,650
SOME OF OUR WORK IN THE CENTER

2549
01:35:47,650 --> 01:35:49,919
FOR CANCER GENOMICS BUT BESIDES

2550
01:35:49,919 --> 01:35:52,555
THAT HE'S JUST AN AMAZING

2551
01:35:52,555 --> 01:35:55,358
INVESTIGATOR ON HIS OWN RIGHT

2552
01:35:55,358 --> 01:36:01,664
AND SORT OF I WOULD SAY

2553
01:36:01,664 --> 01:36:04,401
MIDCAREER ALEX, AND HAS BEEN

2554
01:36:04,401 --> 01:36:06,369
REALLY DOING WORK THAT I THINK

2555
01:36:06,369 --> 01:36:12,575
RESONATES WITH WHAT I JUST GOT

2556
01:36:12,575 --> 01:36:13,943
THROUGH SAYING.

2557
01:36:13,943 --> 01:36:15,378
NTHANKS, LOU AND THANK YOU SO

2558
01:36:15,378 --> 01:36:16,813
MUCH TO THE OPPORTUNITY TO

2559
01:36:16,813 --> 01:36:18,948
PRESENT TO NCI AND EVERYBODY

2560
01:36:18,948 --> 01:36:19,482
THAT'S PRESENT.

2561
01:36:19,482 --> 01:36:22,519
I THINK THE TALK I WILL GIVE

2562
01:36:22,519 --> 01:36:24,020
TODAY, DOVETAILS BEAUTIFULLY ON

2563
01:36:24,020 --> 01:36:26,222
WHAT YOU PRESENTED AND I WILL

2564
01:36:26,222 --> 01:36:29,292
THROW A LITTLE FUEL ON THE FIRE

2565
01:36:29,292 --> 01:36:30,927
AND SAY THAT TCGA HAS MY VOTE

2566
01:36:30,927 --> 01:36:32,495
AND I AM WILLING TO SCREAM TO

2567
01:36:32,495 --> 01:36:33,096
THE HILLS FOR IT.

2568
01:36:33,096 --> 01:36:34,330
SO I WANT TO TELL YOU ABOUT THE

2569
01:36:34,330 --> 01:36:35,999
WORK WE'VE BEEN DOING RECENTLY

2570
01:36:35,999 --> 01:36:37,133
THAT WILL BE FOCUSED ON TRYING

2571
01:36:37,133 --> 01:36:38,468
TO UNDERSTAND THE RELEVANCE OF

2572
01:36:38,468 --> 01:36:39,602
CELL STATE AND I WANT TO TAWRG

2573
01:36:39,602 --> 01:36:41,771
THAT ACTUALLY WE NEED TO MOVE

2574
01:36:41,771 --> 01:36:44,140
FOR A PARADOIM TO WHERE WE THINK

2575
01:36:44,140 --> 01:36:45,675
ABOUT DNETWORKA TO 1 WHERE WE

2576
01:36:45,675 --> 01:36:48,077
THINK ABOUT THE RNA PHENOTYPES

2577
01:36:48,077 --> 01:36:52,816
AS A WAY OF SELECTING THERAPIES

2578
01:36:52,816 --> 01:36:53,116
FOR CANCERS.

2579
01:36:53,116 --> 01:36:57,053
BEFORE I START I WILL SAY I HAVE

2580
01:36:57,053 --> 01:36:59,222
A BUNCH OF FINANCIAL

2581
01:36:59,222 --> 01:37:00,657
DISCLOSURES, FOR TRANSPARENCY I

2582
01:37:00,657 --> 01:37:01,424
PUT THEM HERE.

2583
01:37:01,424 --> 01:37:02,992
WHEN WE THINK ABOUT PRECISION

2584
01:37:02,992 --> 01:37:04,227
MEDICINE PIPELINES WE THINK

2585
01:37:04,227 --> 01:37:06,129
ABOUT DNA AS A FOUNDATION FOR

2586
01:37:06,129 --> 01:37:08,164
IT, TRUTH IN ADVERTISING YOU

2587
01:37:08,164 --> 01:37:10,166
PROBABLY FOUND OUT IF I HAD A

2588
01:37:10,166 --> 01:37:11,668
TUMOR TOMORROW, I WOULD WANT TO

2589
01:37:11,668 --> 01:37:13,670
SEQUENCE IT SO I COULD FIND OUT

2590
01:37:13,670 --> 01:37:14,938
WHAT MUTATIONS EXISTED IN NIGH

2591
01:37:14,938 --> 01:37:16,406
DNA SO WE COULD MAKE THE TYPES

2592
01:37:16,406 --> 01:37:18,274
OF MODELS WE WERE TALKING ABOUT

2593
01:37:18,274 --> 01:37:20,510
AND AND BY CONFIRMING THE

2594
01:37:20,510 --> 01:37:22,245
MUTATIONS EXISTED, I THINK GO IN

2595
01:37:22,245 --> 01:37:23,646
HUGHES, ALL OF TOOLS THAT WOULD

2596
01:37:23,646 --> 01:37:25,381
BE ABLE TO FIGURE OUT WHICH

2597
01:37:25,381 --> 01:37:27,083
DRUGS WOULD BE ACTIONABLE

2598
01:37:27,083 --> 01:37:27,817
AGAINST SPECIFIC MUTATIONS AND

2599
01:37:27,817 --> 01:37:29,586
THIS IS SORT OF THE PROMISE OF

2600
01:37:29,586 --> 01:37:31,354
GENOMICS WHERE WE CAN GO AND

2601
01:37:31,354 --> 01:37:33,089
FIGURE OUT WHAT HAS CHANGED THAT

2602
01:37:33,089 --> 01:37:34,357
MAKES A TUMOR DIFFERENT FROM

2603
01:37:34,357 --> 01:37:36,092
CELL AND SPECIFICALLY GO AFTER

2604
01:37:36,092 --> 01:37:39,796
IT THROUGH INDIVIDUAL DRUGS OR

2605
01:37:39,796 --> 01:37:40,763
COMBINATIONS THEREOF.

2606
01:37:40,763 --> 01:37:42,398
SO I MIGHT ASK HOW HAVE WE DONE

2607
01:37:42,398 --> 01:37:44,667
WITH ALL THE ADVANCES IN

2608
01:37:44,667 --> 01:37:48,304
DENOAMICS AND I WOULD SAY

2609
01:37:48,304 --> 01:37:48,972
UNFORTUNATELY WE WOULDN'T HAVE

2610
01:37:48,972 --> 01:37:50,673
DONE AS WELL AS WE LIKE, THERE

2611
01:37:50,673 --> 01:37:52,542
ARE ONLY A NUMBER OF MUTATIONS

2612
01:37:52,542 --> 01:37:55,078
THAT HAVE ACTUAL MUTATIONS,IME

2613
01:37:55,078 --> 01:37:58,181
SURE YOU'RE AWARE, 40% OF THEM

2614
01:37:58,181 --> 01:38:00,850
ONLY A SMALL FRACTION HAS

2615
01:38:00,850 --> 01:38:02,352
RESPONSES, SO VERY OFTEN WE

2616
01:38:02,352 --> 01:38:03,753
INVOLVE SYSTEMS WHICH MAKES THE

2617
01:38:03,753 --> 01:38:05,154
TREATMENT NO LONGER VIABLE BUT

2618
01:38:05,154 --> 01:38:07,590
WHEN WE THINK ABOUT WHY THIS

2619
01:38:07,590 --> 01:38:08,224
PIPELINE MIGHT FAIL, AT THE

2620
01:38:08,224 --> 01:38:10,426
CENTER OF IT IS THIS IDEA THIS

2621
01:38:10,426 --> 01:38:11,361
DNA ALTERATIONS ARE THE ONLY

2622
01:38:11,361 --> 01:38:14,697
THINGS THAT ARE RELEVANT FOR

2623
01:38:14,697 --> 01:38:15,498
CONTINUING ABOUT DRUG

2624
01:38:15,498 --> 01:38:17,000
SENSITIVITY, SO IF WE THINK

2625
01:38:17,000 --> 01:38:18,868
ABOUT WAWE'RE REALLY TRYING TO

2626
01:38:18,868 --> 01:38:20,603
DO WITH WE CURE CANCER, WE'RE

2627
01:38:20,603 --> 01:38:22,038
NOT TRYING TO KILL A PARTICULAR

2628
01:38:22,038 --> 01:38:23,439
MUTATION, WE THINK ABOUT A LOT

2629
01:38:23,439 --> 01:38:25,174
ABOUT THE IDEA, PRECISION BEING

2630
01:38:25,174 --> 01:38:27,143
DOWN TO THE MOLECULAR CAUSES BUT

2631
01:38:27,143 --> 01:38:29,612
AT THE END OF THE DAY, WE WANT

2632
01:38:29,612 --> 01:38:30,914
TO TARGET INDIVIDUAL CANCER

2633
01:38:30,914 --> 01:38:32,415
CELLS THAT'S WHAT WE'RE TRYING

2634
01:38:32,415 --> 01:38:33,516
TO ERADIATE AND REMOVE.

2635
01:38:33,516 --> 01:38:34,951
IF YOU THINK BACK TO OUR HIGH

2636
01:38:34,951 --> 01:38:36,886
SCHOOL BIOLOGY, I'M SURE YOU ARE

2637
01:38:36,886 --> 01:38:38,621
ALL VERY WELL AWARE THAT WITHIN

2638
01:38:38,621 --> 01:38:41,291
OUR SOWRS, WE HAVE DNA AND A

2639
01:38:41,291 --> 01:38:42,926
STATIC PLURIBU PRINT THAT'S USED

2640
01:38:42,926 --> 01:38:44,694
TO MAKE A DIFFERENT CELL TYPES,

2641
01:38:44,694 --> 01:38:47,430
EVERYTHING FROM IMMUNE CELLS,

2642
01:38:47,430 --> 01:38:48,932
MUSCLE CELLS AND WHAT CHANGES,

2643
01:38:48,932 --> 01:38:51,801
WHAT CELL TYPE YOU GET IS NOT

2644
01:38:51,801 --> 01:38:53,236
THE DNA ITSELF BUT ACTUALLY A

2645
01:38:53,236 --> 01:38:54,270
MEMBER OF LAYERS OF REGULATION

2646
01:38:54,270 --> 01:38:57,340
IN THE CELL EMPLOY SO THINGS

2647
01:38:57,340 --> 01:39:00,276
LIKE EPIGENETICS AS WELL AS

2648
01:39:00,276 --> 01:39:01,544
INTERACTIONS AND THESE STATES

2649
01:39:01,544 --> 01:39:03,580
THAT LET YOU GET MULTIPLE

2650
01:39:03,580 --> 01:39:05,415
DIFFERENT CELL TYPES FROM 1

2651
01:39:05,415 --> 01:39:07,317
STATIC CODE LIKE READING

2652
01:39:07,317 --> 01:39:08,718
DIFFERENT BOOKS IN THE LIBRARY

2653
01:39:08,718 --> 01:39:10,219
TO GET DIFFERENT OUTPUTS NOW

2654
01:39:10,219 --> 01:39:11,654
WHEN WE THINK ABOUT CANCER, WE

2655
01:39:11,654 --> 01:39:13,089
HAVE THE SAME PLACE WHERE YOU

2656
01:39:13,089 --> 01:39:15,158
HAVE A MUTATED DNETWORKA CODE

2657
01:39:15,158 --> 01:39:16,459
BUT YOU CAN RESULT IN DIFFERENT

2658
01:39:16,459 --> 01:39:18,695
STATES WHICH MY BE RESPONSIVE TO

2659
01:39:18,695 --> 01:39:19,762
YOUR IMMUNE SYSTEM, SOME OF

2660
01:39:19,762 --> 01:39:20,630
WHICH MIGHT BE SENSITIVE TO

2661
01:39:20,630 --> 01:39:22,432
DRUG, AND SOME OF WHICH MIGHT

2662
01:39:22,432 --> 01:39:23,433
NOT BE RESISTANT.

2663
01:39:23,433 --> 01:39:25,702
SO YOU CAN ASK YOURSELF IF THIS

2664
01:39:25,702 --> 01:39:28,004
DNA CAN GIVE RISE TO MULTIPLE

2665
01:39:28,004 --> 01:39:29,038
STATES AND CAN UNDERLIE

2666
01:39:29,038 --> 01:39:31,074
RESISTANCE HOW DO WE FIGURE OUT

2667
01:39:31,074 --> 01:39:32,942
WHICH STATES EXIST?

2668
01:39:32,942 --> 01:39:34,243
WELL, OVER THE PAST SEVERAL

2669
01:39:34,243 --> 01:39:35,912
YEARS WE AND OTHER VS BEEN

2670
01:39:35,912 --> 01:39:37,413
INVOLVED IN DEVELOPING A NUMBER

2671
01:39:37,413 --> 01:39:38,381
OF TECHNOLOGIES THAT ENABLE TO

2672
01:39:38,381 --> 01:39:41,484
US TO LOOK AT CELLS FOR

2673
01:39:41,484 --> 01:39:42,118
UNPRECEDENTED RESOLUTION WHERE

2674
01:39:42,118 --> 01:39:43,953
WE TAKE A COLLECTION OF ISOLATED

2675
01:39:43,953 --> 01:39:46,189
CELLS AND LOAD THEM IN

2676
01:39:46,189 --> 01:39:46,756
INCREASINGLY SOPHISTICATED

2677
01:39:46,756 --> 01:39:48,191
DEVICES WHERE WE CAN CAPTURE

2678
01:39:48,191 --> 01:39:50,293
THEM AND   PERFORM THE ADVANCE

2679
01:39:50,293 --> 01:39:52,295
MOLECULAR PROCESSING, SAY FOR

2680
01:39:52,295 --> 01:39:53,630
EXAMPLE, REUSING CAPTURE

2681
01:39:53,630 --> 01:39:55,398
REAGENTS TO GRAB ALL THE RNA,

2682
01:39:55,398 --> 01:39:57,433
AND A CELL IS GIIVE EVERY SINGLE

2683
01:39:57,433 --> 01:39:59,035
MOMENT AND SEQUENCING MEASURE

2684
01:39:59,035 --> 01:40:00,803
THE ACTIVITY OF 20,000 VARIABLES

2685
01:40:00,803 --> 01:40:01,604
IN AN INDIVIDUAL CELL EMPLOY

2686
01:40:01,604 --> 01:40:03,339
WHEN YOU THINK ABOUT THIS, THIS

2687
01:40:03,339 --> 01:40:05,074
GIVES US ABOUT A TRILLION DATA

2688
01:40:05,074 --> 01:40:06,476
POINTS FROM EACH INDIVIDUAL

2689
01:40:06,476 --> 01:40:08,277
BIOPSY WE MIGHT TAKE AS A WAY OF

2690
01:40:08,277 --> 01:40:09,746
THINKING ABOUT WHAT'S HAPPENING

2691
01:40:09,746 --> 01:40:12,115
IN CANCER AND HOW TO COUNTERACT

2692
01:40:12,115 --> 01:40:12,281
IT.

2693
01:40:12,281 --> 01:40:13,850
AND JUST TO GIVE YOU AN IDEA OF

2694
01:40:13,850 --> 01:40:17,854
HOW FAR THE FIELD HAS COME, IT'S

2695
01:40:17,854 --> 01:40:18,755
NOT JUST RNARE--ADMINISTRATIVE

2696
01:40:18,755 --> 01:40:21,524
AT THIS POINT, THERE'S BEEN SO

2697
01:40:21,524 --> 01:40:22,458
MANY INCREDIBLE DEVELOPS THAT WE

2698
01:40:22,458 --> 01:40:24,460
MEASURE CELLS AND WE CAN LOOK AT

2699
01:40:24,460 --> 01:40:26,429
WHICH REGIONS ARE BEING RED AND

2700
01:40:26,429 --> 01:40:27,497
THE ACCESSIBILITY LIKE LUIS WAS

2701
01:40:27,497 --> 01:40:29,232
TALKING ABOUT MINUTE AGO

2702
01:40:29,232 --> 01:40:30,133
ACCIDENT MEASURE SURFACE

2703
01:40:30,133 --> 01:40:31,367
PROTEINS AND DO MANY OF THESE

2704
01:40:31,367 --> 01:40:34,003
THINGS IN PARALLEL TO GET THESE

2705
01:40:34,003 --> 01:40:34,804
INCREDIBLY IMPRESSIVE AND

2706
01:40:34,804 --> 01:40:35,772
COMPREHENSIVE USE OF WHAT'S

2707
01:40:35,772 --> 01:40:37,840
HAPPENING WITHIN OUR CANCER

2708
01:40:37,840 --> 01:40:38,074
CELLS.

2709
01:40:38,074 --> 01:40:41,177
NOW WHAT THIS DOES, IT GIVES US

2710
01:40:41,177 --> 01:40:42,679
AN INCREDIBLE OPPORTUNITY TO

2711
01:40:42,679 --> 01:40:44,080
GIVE US THINGS THAT LOU WAS

2712
01:40:44,080 --> 01:40:46,182
TALKING ABOUT SO THIS IS A STUDY

2713
01:40:46,182 --> 01:40:47,884
I WILL TELL INCREDIBLY SHORT

2714
01:40:47,884 --> 01:40:49,185
FASHION AND THE BUNCH LINE AND

2715
01:40:49,185 --> 01:40:50,586
TALK ABOUT THIS OFFLINE BUT VERY

2716
01:40:50,586 --> 01:40:52,488
MUCH IN LINE WITH WHAT WAS JUST

2717
01:40:52,488 --> 01:40:52,889
PRESENTED.

2718
01:40:52,889 --> 01:40:54,557
WHAT WE WANT TO UNDERSTAND IS

2719
01:40:54,557 --> 01:40:56,059
WHAT IS A PRIMARY TUMOR LOOK

2720
01:40:56,059 --> 01:40:58,528
LIKE AND HOW GOOD IS THE MODEL

2721
01:40:58,528 --> 01:41:02,498
IN REPRESENTING IT SO WE TOOK

2722
01:41:02,498 --> 01:41:03,700
BIOPSIES IN CANCER WHERE THERE

2723
01:41:03,700 --> 01:41:06,035
ARE NO MUTATIONS BUT THERE ARE

2724
01:41:06,035 --> 01:41:11,007
VERY GOOD THERAPIES, WE  

2725
01:41:11,007 --> 01:41:13,443
PERFORMED THE PROFILING WHERE WE

2726
01:41:13,443 --> 01:41:16,145
IMRESESSED THE EPITHELIAL LIKE

2727
01:41:16,145 --> 01:41:17,980
GENES AND WERE LESS AGGRESSIVE

2728
01:41:17,980 --> 01:41:19,615
AND ON THE OTHER SIDE WE

2729
01:41:19,615 --> 01:41:20,783
EXPRESSED THE BASAL LIKE GENES

2730
01:41:20,783 --> 01:41:23,653
THAT ARE MORE ASSOCIATED WITH

2731
01:41:23,653 --> 01:41:26,422
STEMS AND AS WELL THOSE THAT DID

2732
01:41:26,422 --> 01:41:26,789
BOTH.

2733
01:41:26,789 --> 01:41:28,858
IN PARALLEL WE MADE ORGANOIDS

2734
01:41:28,858 --> 01:41:30,193
FROM THE MATCHED SAMPLES,

2735
01:41:30,193 --> 01:41:33,896
CHECKED THEM OVER TIME AND

2736
01:41:33,896 --> 01:41:35,431
FIGURED OUT MODELS WERE SKEWED

2737
01:41:35,431 --> 01:41:37,567
IN VIVO AND BY GOING BACK AND

2738
01:41:37,567 --> 01:41:38,835
MODIFYING CULTURE CONDITIONS TO

2739
01:41:38,835 --> 01:41:40,002
RECREATE WHAT YOU WOULD ACTUALLY

2740
01:41:40,002 --> 01:41:43,439
SEE IN A PERSON, WE ARE ABLE TO

2741
01:41:43,439 --> 01:41:44,474
RECREATE THIS ENTIRE HIERARCHY

2742
01:41:44,474 --> 01:41:45,241
CELL STATES.

2743
01:41:45,241 --> 01:41:47,910
SO THE REASON I THINK THIS IS SO

2744
01:41:47,910 --> 01:41:50,079
IMPORTANT IS BECAUSE IT'S LESS

2745
01:41:50,079 --> 01:41:50,713
FUNCTIONAL CONSEQUENCES, SO TO

2746
01:41:50,713 --> 01:41:52,682
SHOW DAILY BASIS THEA TO MAKE

2747
01:41:52,682 --> 01:41:54,717
THIS GRANULAR, IT'S A PLOT, IT'S

2748
01:41:54,717 --> 01:41:56,352
A DIFFERENT THAN THE METHOD LOU

2749
01:41:56,352 --> 01:41:57,854
SHOWED YOU BEFORE AND WHAT I

2750
01:41:57,854 --> 01:41:59,055
NEED YOU TO KNOW IS EACH

2751
01:41:59,055 --> 01:42:01,824
INDIVIDUAL POINT IS A CELL, SO

2752
01:42:01,824 --> 01:42:03,493
THESE ARE CANCER CELLS THAT ARE

2753
01:42:03,493 --> 01:42:06,462
ORGANOIDS AND YOU HAVE THIS

2754
01:42:06,462 --> 01:42:07,130
EPITHELIAL LIKE CLASSICALITATEOT

2755
01:42:07,130 --> 01:42:09,065
RIGHT HAND SIDE AND MY MODCELL

2756
01:42:09,065 --> 01:42:10,366
SEVERELY BIASED TOWARDS THIS,

2757
01:42:10,366 --> 01:42:13,069
WHEN I ADD TGF BETA SIGNALING

2758
01:42:13,069 --> 01:42:14,670
MOLECULE FOUND IN THE MICROVIRMT

2759
01:42:14,670 --> 01:42:16,773
IN VIVO, WHAT CAN YOU SEE IS

2760
01:42:16,773 --> 01:42:18,741
OVERTIME MY MODEL MOVES TO

2761
01:42:18,741 --> 01:42:20,343
RECREATE THIS MORE INTERMEDIATE

2762
01:42:20,343 --> 01:42:22,779
AND BASAL LIKE STATE AND IF I

2763
01:42:22,779 --> 01:42:23,980
REMOVE TGF BETA THE MODEL GOES

2764
01:42:23,980 --> 01:42:25,982
BACK TO WHERE IT WAS PREVIOUSLY.

2765
01:42:25,982 --> 01:42:27,717
NOW YOU MIGHT SAY WELL THIS IS

2766
01:42:27,717 --> 01:42:28,785
INTERESTING, CAN YOU PLAY WITH

2767
01:42:28,785 --> 01:42:30,286
THE MODEL BUT WHY DOES IT

2768
01:42:30,286 --> 01:42:30,520
MATTER.

2769
01:42:30,520 --> 01:42:34,757
THE REASON IS MATTERS IS THAT

2770
01:42:34,757 --> 01:42:35,658
THIS DRAMATICALLY HAS RESPONSES

2771
01:42:35,658 --> 01:42:41,998
SO IF WE THINK ABOUT CHEMO

2772
01:42:41,998 --> 01:42:44,000
THERAPIES, BEFORE WE ADD TGP

2773
01:42:44,000 --> 01:42:45,968
BETA, AS WE ADD IT OVER TIME WE

2774
01:42:45,968 --> 01:42:47,537
GET A HUNDRED FOLD REDUCTION IN

2775
01:42:47,537 --> 01:42:49,539
HOW SENSITIVE IT IS AND IN THE

2776
01:42:49,539 --> 01:42:51,407
MODEL WHERE WE STRIPPED IT OUT

2777
01:42:51,407 --> 01:42:53,643
AND TRIPPED IT BACK, AND WE GET

2778
01:42:53,643 --> 01:42:55,978
THE SAME RESPONSE ORIGINALLY AND

2779
01:42:55,978 --> 01:42:57,747
AS WE THINK ABOUT ALTERING THE

2780
01:42:57,747 --> 01:42:59,081
STATES WITHIN THE SAME MODEL AND

2781
01:42:59,081 --> 01:43:00,917
TESTING IT, WE FIND THE

2782
01:43:00,917 --> 01:43:02,885
CLASSICAL EPITHELIAL LIKE STATE,

2783
01:43:02,885 --> 01:43:04,320
WE'RE INCREDIBLY SEPSATIVE TO

2784
01:43:04,320 --> 01:43:06,289
CHEMO THERAPIES, WE WERE VERY

2785
01:43:06,289 --> 01:43:08,157
SENSITIVE TO MAP KINASE

2786
01:43:08,157 --> 01:43:09,792
INHIBITORS SO THE REALLY

2787
01:43:09,792 --> 01:43:11,093
CRITICAL TAKE AWAIP FOR ME AT

2788
01:43:11,093 --> 01:43:12,161
LEAST IN THINKING ABOUT THIS IS

2789
01:43:12,161 --> 01:43:13,429
WHAT WE FIND IS THAT STATE

2790
01:43:13,429 --> 01:43:15,598
MATTER ANDS THAT IT INFLUENCES

2791
01:43:15,598 --> 01:43:16,933
DRUG RESPONSES AND YET THIS

2792
01:43:16,933 --> 01:43:17,900
ISN'T SOMETHING WE MODEL AND

2793
01:43:17,900 --> 01:43:21,771
THINK ABOUT WHEN WE SELECT DRUGS

2794
01:43:21,771 --> 01:43:23,506
FOR PATIENTS AND I THINK THIS

2795
01:43:23,506 --> 01:43:26,042
MAY BE VERY ABSTRACT BUT I THINK

2796
01:43:26,042 --> 01:43:27,443
THE EASIEST WAY ABOUT THINKING

2797
01:43:27,443 --> 01:43:28,578
WHATIME TELLING YOU IS THAT

2798
01:43:28,578 --> 01:43:31,080
ENSTED OF THINKING ABOUT DNA

2799
01:43:31,080 --> 01:43:32,148
MUTATIONS WE THINK ABOUT HOW

2800
01:43:32,148 --> 01:43:33,549
CELLS USE THEM FOR THE ACTIVITY

2801
01:43:33,549 --> 01:43:35,218
PATHWAY ANDS THEN WE TARGET

2802
01:43:35,218 --> 01:43:36,319
THOSE PATHWAYS WE CAN DO A

2803
01:43:36,319 --> 01:43:38,154
BETTER JOB OF KILLING CANCER

2804
01:43:38,154 --> 01:43:39,789
CELLS VERY MUCH LIKE LOU

2805
01:43:39,789 --> 01:43:41,457
PRESENTED SO YOU MIGHT MIGHT SAY

2806
01:43:41,457 --> 01:43:42,658
HOW DOES THIS HELP US IN

2807
01:43:42,658 --> 01:43:44,927
THINKING ABOUT HOW PATES MIGHT

2808
01:43:44,927 --> 01:43:45,161
RESPOND?

2809
01:43:45,161 --> 01:43:46,596
WELL OUR DATA WOULD SUGGIEST

2810
01:43:46,596 --> 01:43:48,965
THAT OUR PATIENTS THAT HAVE THIS

2811
01:43:48,965 --> 01:43:50,600
MORE EPITHELIAL LIKE STATE WOULD

2812
01:43:50,600 --> 01:43:52,001
BE SUSCEPTIBLE TO CHEMO THERAPY

2813
01:43:52,001 --> 01:43:53,169
CROSS LINKING THIS IS HOW WE

2814
01:43:53,169 --> 01:43:55,271
LOOK AT WHEN PATIENTS RESPOND

2815
01:43:55,271 --> 01:43:55,571
CLINICALLY.

2816
01:43:55,571 --> 01:43:57,673
WE FIND IT DOES AN INCREDIBLE

2817
01:43:57,673 --> 01:43:58,307
LOAMACYY GOOD YOB CORPS.

2818
01:43:58,307 --> 01:43:59,909
THE PEOPLE WHO HAVE RESPONSES IN

2819
01:43:59,909 --> 01:44:01,844
THE TUMOR SIZE THAT THOSE THAT

2820
01:44:01,844 --> 01:44:03,779
HAVE THE CLASSICAL LIKE STATE,

2821
01:44:03,779 --> 01:44:05,882
THOSE WHO GET OUTCROPPED BY THE

2822
01:44:05,882 --> 01:44:07,950
TUMOR BY THE 1S THAT ARE MORE

2823
01:44:07,950 --> 01:44:08,951
BASAL LIKE.

2824
01:44:08,951 --> 01:44:10,253
THIS IS AN INTERESTING PARDIME

2825
01:44:10,253 --> 01:44:12,588
BUT WE DON'T WANT TO JUST THINK

2826
01:44:12,588 --> 01:44:14,190
ABOUT HOW INDIVIDUALS IN THE

2827
01:44:14,190 --> 01:44:17,493
PDAK, WE WANT TO THINK ABOUT HOW

2828
01:44:17,493 --> 01:44:19,128
WE EXTEND THEM ACROSS THE

2829
01:44:19,128 --> 01:44:21,364
MULTIPLE CANCERS LIKE WHAT WE

2830
01:44:21,364 --> 01:44:21,797
JUST SHOWED YOU.

2831
01:44:21,797 --> 01:44:23,032
SO I WOULD HAVE THOUGHT ABOUT IT

2832
01:44:23,032 --> 01:44:24,233
LIKE A VIRTUAL MACHINE YELL

2833
01:44:24,233 --> 01:44:25,301
STACK WHERE WE MOVE THROUGH

2834
01:44:25,301 --> 01:44:26,502
WHAT'S HAPPENING IN THE BIOLOGY

2835
01:44:26,502 --> 01:44:27,904
IN VIVO AND WE THINK ABOUT HOW

2836
01:44:27,904 --> 01:44:29,672
WE CAN CREATE ACCURATE MODELS

2837
01:44:29,672 --> 01:44:30,840
THAT REPRESENT THE SPECTRUM OF

2838
01:44:30,840 --> 01:44:32,441
DIFFERENT STATES THAT WE SEE AND

2839
01:44:32,441 --> 01:44:34,143
THEN USE THAT SUBSTRATE FIGURING

2840
01:44:34,143 --> 01:44:36,612
OUT WHAT ARE THE TRITE DRUGS TO

2841
01:44:36,612 --> 01:44:37,079
TARGET THOSE THINGS.

2842
01:44:37,079 --> 01:44:38,581
SO YOU MIGHT ASK WHAT HAPPEN

2843
01:44:38,581 --> 01:44:40,883
FIST WE TRY TO DO THIS IN OTHER

2844
01:44:40,883 --> 01:44:42,518
CANCERS, IN PARTNERSHIP WITH THE

2845
01:44:42,518 --> 01:44:43,519
NCI, THEY HAVE BEEN TRYING TO

2846
01:44:43,519 --> 01:44:46,355
USE SOME OF THE TCGA SASMYS

2847
01:44:46,355 --> 01:44:50,293
USING A VARIANT OF THIS APPROACH

2848
01:44:50,293 --> 01:44:52,061
CALLED SINGLE NUCLEACE RNA-SEQ

2849
01:44:52,061 --> 01:44:54,530
TO SEE WHAT'S SHOVED ACROSS

2850
01:44:54,530 --> 01:44:55,031
MULTIDIFFERENT CANCERS.

2851
01:44:55,031 --> 01:44:57,233
WHEN YOU LOOK AT THIS, WE FIND

2852
01:44:57,233 --> 01:44:58,534
THE SAME BASAL STATE TALKING

2853
01:44:58,534 --> 01:45:00,770
ABOUT THE CONTEXT OF PDAC, AND

2854
01:45:00,770 --> 01:45:02,772
IT OCCURS IN MULTIPLE DIFFERENT

2855
01:45:02,772 --> 01:45:04,040
CANCERS, I WOULD LOVE TO TELL

2856
01:45:04,040 --> 01:45:06,275
YOU HOW WE'RE THINKING ABOUT

2857
01:45:06,275 --> 01:45:07,677
OPTIMIZING MODELS AND WORKING ON

2858
01:45:07,677 --> 01:45:08,544
TARGETS MAYBE DURING THE

2859
01:45:08,544 --> 01:45:10,346
QUESTION SECTION, BUT I MIGHT

2860
01:45:10,346 --> 01:45:12,581
ASK HOW USELESS THIS WILL BE

2861
01:45:12,581 --> 01:45:13,149
ACROSS CANCERS, CREATING

2862
01:45:13,149 --> 01:45:14,717
SOMETHING NEW WHERE WE NEED EVEN

2863
01:45:14,717 --> 01:45:17,119
MORE COMPLEXITY AND I THINK THE

2864
01:45:17,119 --> 01:45:17,620
ANSWER IS NO.

2865
01:45:17,620 --> 01:45:20,823
SO IF WE GO AND LOOK AT EXISTING

2866
01:45:20,823 --> 01:45:23,159
DATA SETS FOR DEPENDENCY, WE CAN

2867
01:45:23,159 --> 01:45:25,661
SEE THAT REGARDLESS OF THE

2868
01:45:25,661 --> 01:45:26,829
LINEAGE OF WHERE CANCER COMES

2869
01:45:26,829 --> 01:45:29,031
FROM, IF WE LOOK AT THE STATE WE

2870
01:45:29,031 --> 01:45:30,466
CAN PREDICT WHICH PROTEIN

2871
01:45:30,466 --> 01:45:31,734
COMPLEX TURBATIONS IT WILL BE

2872
01:45:31,734 --> 01:45:33,402
SENSITIVE TO, SO WE FIND

2873
01:45:33,402 --> 01:45:34,704
SIMILARITY IN HOUSEHOLDS AND HOW

2874
01:45:34,704 --> 01:45:37,573
THEY WILL RESPOND TO PARTICULAR

2875
01:45:37,573 --> 01:45:39,608
KNOCK DOWNS, REGARDLESS OF THE

2876
01:45:39,608 --> 01:45:42,845
CANCER ORIGIN, BASED ON WHAT HAD

2877
01:45:42,845 --> 01:45:43,913
IS THERE, MORE MESSENTERIEN

2878
01:45:43,913 --> 01:45:48,150
CHIMAL LIKE, SO WHAT WE'VE BEEN

2879
01:45:48,150 --> 01:45:49,352
BEENINGING ABOUT AT OUR

2880
01:45:49,352 --> 01:45:50,586
LABORATORY, IS HOW TO COMPLETE

2881
01:45:50,586 --> 01:45:50,987
THE SQUARE.

2882
01:45:50,987 --> 01:45:53,756
HOW DO WE WORK OUR WAY ACROSS

2883
01:45:53,756 --> 01:45:55,124
CREATING THESE VIRTUAL MACHINIAL

2884
01:45:55,124 --> 01:45:56,425
STACKS AND CROSS CANCERS TO

2885
01:45:56,425 --> 01:45:57,727
THINK ABOUT THESE CANCER

2886
01:45:57,727 --> 01:46:01,464
ECOSYSTEMS SO WE CAN CREATE HIGH

2887
01:46:01,464 --> 01:46:02,331
FIDELITY MODELS, CREATE

2888
01:46:02,331 --> 01:46:03,132
PARTICULAR COMPOUND ANDS THEN,

2889
01:46:03,132 --> 01:46:06,535
YOU KNOW GETTING BACK TO WHAT

2890
01:46:06,535 --> 01:46:08,404
LOU SHOWED IN PATHWAYS, BEYOND

2891
01:46:08,404 --> 01:46:10,506
THINKING ABOUT THE AGHT PATHWAY

2892
01:46:10,506 --> 01:46:12,475
IN CONCANCKER CELL AND 1

2893
01:46:12,475 --> 01:46:13,542
PARALLEL PACK WAIGHT, WE CAN PUT

2894
01:46:13,542 --> 01:46:15,311
A PAPER ON THE BIOARCHIVE AND

2895
01:46:15,311 --> 01:46:17,847
THINK A LOT ABOUT THE BCR ABLE

2896
01:46:17,847 --> 01:46:20,049
THAT LOW TALKED ABOUT, INSTEAD

2897
01:46:20,049 --> 01:46:21,917
WE CAN MOVE TO A PARADIGM WHERE

2898
01:46:21,917 --> 01:46:23,686
WE MOVE THE IMMUNE CELL, NOT

2899
01:46:23,686 --> 01:46:24,987
NECESSARILY TO MOVE THE CANCER

2900
01:46:24,987 --> 01:46:26,489
CELL BUT CONTROL THE STATE OF

2901
01:46:26,489 --> 01:46:27,890
THE CANCER CELL SO IT BECOMES

2902
01:46:27,890 --> 01:46:29,492
MORE SENSITIVE TO A PARTICULAR

2903
01:46:29,492 --> 01:46:32,461
DRUG CREATING THE SYNTHETIC

2904
01:46:32,461 --> 01:46:33,796
LETHAL OF WHICH LOU SPOKE, SO

2905
01:46:33,796 --> 01:46:35,097
WITH THAT I WANT TO THANK MY

2906
01:46:35,097 --> 01:46:36,332
TEAM TO DO THE WORK PRECEPTED

2907
01:46:36,332 --> 01:46:37,933
HERE AND I WANT TO THANK ALL OF

2908
01:46:37,933 --> 01:46:39,502
OUR FUNDERS AND ALL OUR

2909
01:46:39,502 --> 01:46:40,770
COLLABORATORS BUT MOSTLY I WANT

2910
01:46:40,770 --> 01:46:42,505
TO THANK PATIENTS AND FAMILIES,

2911
01:46:42,505 --> 01:46:44,573
IT'S NOT LOST ON ME THAT ALL THE

2912
01:46:44,573 --> 01:46:46,108
SCIENCE WE DO IS BECAUSE PEOPLE

2913
01:46:46,108 --> 01:46:47,877
AT THE MOST VULNERABLE POINTS IN

2914
01:46:47,877 --> 01:46:49,278
THEIR LIVES TAKE TIME TO PARTNER

2915
01:46:49,278 --> 01:46:50,813
WITH US IF THERE ARE BETTER

2916
01:46:50,813 --> 01:46:52,314
CURES FOR THEMSELVES AND OTHERS

2917
01:46:52,314 --> 01:46:54,817
THAT COME AFTER THEM AND OWE

2918
01:46:54,817 --> 01:46:56,919
THEM AN INCREDIBLE DEBT OF

2919
01:46:56,919 --> 01:46:58,120
GRATITUDE AND AN OPPORTUNITY TO

2920
01:46:58,120 --> 01:46:59,121
RESPECT THEIR WISHES AND MAKE

2921
01:46:59,121 --> 01:47:01,290
SURE WE DO THE BEST TOO CURE

2922
01:47:01,290 --> 01:47:01,791
OTHERS MOVING FORWARD.

2923
01:47:01,791 --> 01:47:02,925
WITH THAT I WILL SAY THANK YOU

2924
01:47:02,925 --> 01:47:05,461
FOR THE OPPORTUNITY AND WITH LOU

2925
01:47:05,461 --> 01:47:06,529
TAKE ANY QUESTIONS, THANKS FOR

2926
01:47:06,529 --> 01:47:09,365
HAVING ME THIS MORNING.

2927
01:47:09,365 --> 01:47:13,736
NGREAT. 

2928
01:47:13,736 --> 01:47:14,303
THANKS, ALEX.

2929
01:47:14,303 --> 01:47:16,205
>> SO A LOT OF HANDS BUT I
WILL

2930
01:47:16,205 --> 01:47:17,973
START WITH TREY BECAUSE HE WAS

2931
01:47:17,973 --> 01:47:19,008
CALLED OUT, PACIFICALLY AND THEN

2932
01:47:19,008 --> 01:47:20,776
I WILL WORK MY WAY AROUND THE

2933
01:47:20,776 --> 01:47:23,446
TABLE, I'M LOOKING IN BOTH

2934
01:47:23,446 --> 01:47:24,547
DIRECTIONS, WE HAVE ABOUT 10

2935
01:47:24,547 --> 01:47:25,915
MINUTES, LOTS OF QUESTIONS SO

2936
01:47:25,915 --> 01:47:36,392
TRY TO KEEP IT SUSSTINKT AND

2937
01:47:47,736 --> 01:47:49,505
TO--WE ACTUALLY HAVE NO IDEA

2938
01:47:49,505 --> 01:47:51,807
WHAT THE TRUE INTERRELATION IS

2939
01:47:51,807 --> 01:47:53,576
BETWEEN THOSE AND MAYBE A

2940
01:47:53,576 --> 01:47:54,810
PROJECT LIKE LOU PROPOSES CAN

2941
01:47:54,810 --> 01:47:56,846
HELP GET TO THE BOTTOM OF IT,

2942
01:47:56,846 --> 01:47:58,214
HOW MANY TRANSCRIPTIONAL CHANGES

2943
01:47:58,214 --> 01:48:00,082
THAT YOU OBSERVE ALEX HAVE

2944
01:48:00,082 --> 01:48:01,884
GENETIC LESIONS USHEDNEATH THEM.

2945
01:48:01,884 --> 01:48:02,785
VICE VERSA, RIGHT?

2946
01:48:02,785 --> 01:48:05,321
HOW MANY GENETIC LESIONS LEAD TO

2947
01:48:05,321 --> 01:48:07,523
HAVE AN EFFECT ON CANCER BUT

2948
01:48:07,523 --> 01:48:09,024
HAVE NO TRANSCRIPTIONAL

2949
01:48:09,024 --> 01:48:10,192
SIGNATURE, WE HAVE ANECDOTES BUT

2950
01:48:10,192 --> 01:48:12,828
WE HAVE NO SYSTEMATIC

2951
01:48:12,828 --> 01:48:14,230
ACKNOWLEDGES, THAT WOULD BE .1

2952
01:48:14,230 --> 01:48:17,032
AND I WILL SNEAK IN, .2, YAWN,

2953
01:48:17,032 --> 01:48:20,002
SORRY, I THINK THE KEY FOR

2954
01:48:20,002 --> 01:48:21,303
MAKING THIS MAYBE NOT AS MANY

2955
01:48:21,303 --> 01:48:23,506
KEYS BUT AS YOU KNOW THE HUMAN

2956
01:48:23,506 --> 01:48:24,907
GENOME PROJECT ALREADY WAS VERY

2957
01:48:24,907 --> 01:48:28,677
HARD TO SELL, BACK IN THE DAY,

2958
01:48:28,677 --> 01:48:32,515
AND THAT'S A MUCH SIMPLER GOAL,

2959
01:48:32,515 --> 01:48:34,216
THERE'S 3 BILLION LETTERS, WHAT

2960
01:48:34,216 --> 01:48:35,851
ARE THEY IN AND YOU'RE DONE.

2961
01:48:35,851 --> 01:48:39,054
SO I'M SURE PEOPLE ARE GOING TO

2962
01:48:39,054 --> 01:48:40,923
ASK THESE QUESTIONS, HOW YOU

2963
01:48:40,923 --> 01:48:42,391
EXACTLY PINPOINTING THE

2964
01:48:42,391 --> 01:48:43,225
DEFINITION OF THIS THING IT'S

2965
01:48:43,225 --> 01:48:45,361
GOING TO BE WHERE HE DIES IF IT

2966
01:48:45,361 --> 01:48:46,562
DIES AND RIGHT, AND SO LET'S

2967
01:48:46,562 --> 01:48:49,632
MAKE SURE IT'S NOT GOING TO DIE

2968
01:48:49,632 --> 01:48:51,934
AND A RELATION TO THAT QUESTION

2969
01:48:51,934 --> 01:48:53,235
IS HOW DO YOU THINK ABOUT THIS

2970
01:48:53,235 --> 01:48:56,338
IN RELATION TO THE

2971
01:48:56,338 --> 01:48:57,273
OTHER--THERE'S SIMILAR PROJECTS

2972
01:48:57,273 --> 01:49:00,476
OUT THERE BY NHGRI, LINX,

2973
01:49:00,476 --> 01:49:05,214
SOMETHING WAY IN THE PAST CALLED

2974
01:49:05,214 --> 01:49:06,415
THE ALLIANCE SORRY CELL

2975
01:49:06,415 --> 01:49:06,682
SIGNALING.

2976
01:49:06,682 --> 01:49:08,384
ALL OF THIS, WELL, THEY DIDN'T

2977
01:49:08,384 --> 01:49:10,386
HAVE THE CELL MODELS, NUMBER 1

2978
01:49:10,386 --> 01:49:11,854
EMPLOY RIGHT IN BUT THERE'S

2979
01:49:11,854 --> 01:49:13,322
OTHER DIFFERENCES THAT WILL BE

2980
01:49:13,322 --> 01:49:17,960
IMPORTANT TO DEFINE NTHANK YOU.

2981
01:49:17,960 --> 01:49:23,465
>> RIGHT, SO, NEDRA --NED

2982
01:49:23,465 --> 01:49:24,633
SHARPLESS THE DOCTOR WHEN I

2983
01:49:24,633 --> 01:49:25,701
FIRST PITCHED THIS AND TOGETHER

2984
01:49:25,701 --> 01:49:29,238
WE TALKED ABOUT JUST HOW YOU

2985
01:49:29,238 --> 01:49:32,775
WOULD ROLE IT OUT IN A WAY THAT

2986
01:49:32,775 --> 01:49:35,711
SEEMED PALLETTABLE AND WHAT WE

2987
01:49:35,711 --> 01:49:39,648
ENDED UP IS SORT OF LIKE TCGA TO

2988
01:49:39,648 --> 01:49:41,116
SAY I'M FIRST FOCUSING ON THIS

2989
01:49:41,116 --> 01:49:44,920
CANCER AND I WANT TO COMPLETELY

2990
01:49:44,920 --> 01:49:47,256
REDEFINE THE REGULATORY NETWORKS

2991
01:49:47,256 --> 01:49:50,359
IN THAT ANSWER TYPE AND THERE'S

2992
01:49:50,359 --> 01:49:52,428
LOTS--AND THAT IMMEDIATELY

2993
01:49:52,428 --> 01:49:55,030
NARROWS THE FOCUS TO A

2994
01:49:55,030 --> 01:49:55,965
PARTICULAR EPIGENETIC SPACE, A

2995
01:49:55,965 --> 01:49:57,266
PARTICULAR SET, AND I THINK

2996
01:49:57,266 --> 01:50:02,438
THAT'S A GOOD WAY TO FRAME THIS

2997
01:50:02,438 --> 01:50:04,740
WITH RESPECT TO OTHER

2998
01:50:04,740 --> 01:50:05,808
ACTIVITIES, I DON'T THINK PEOPLE

2999
01:50:05,808 --> 01:50:08,310
ARE DOING THOSE OTHER ACTIVITIES

3000
01:50:08,310 --> 01:50:10,279
TO COME UP WITH COMBINATION

3001
01:50:10,279 --> 01:50:12,047
THERAPIES FOR OUR PATIENTS.

3002
01:50:12,047 --> 01:50:16,252
AND SO THAT'S OUR GOAL AND WE

3003
01:50:16,252 --> 01:50:18,420
WILL IN THE PROCESS DO GREAT

3004
01:50:18,420 --> 01:50:19,922
BASIC SCIENCE AND HAVE NEW

3005
01:50:19,922 --> 01:50:21,357
NETWORKS THAT WILL BE AVAILABLE

3006
01:50:21,357 --> 01:50:23,192
TO ALL THE SCIENTISTS IN THE

3007
01:50:23,192 --> 01:50:26,295
WORLD BUT WE WANT TO COME UP

3008
01:50:26,295 --> 01:50:28,163
WITH NEW THERAPIES AND THAT'S

3009
01:50:28,163 --> 01:50:30,733
THE ANSWER.

3010
01:50:30,733 --> 01:50:31,033
>> GREAT.

3011
01:50:31,033 --> 01:50:33,302
I THINK WE HAVE TO, I THINK WE

3012
01:50:33,302 --> 01:50:35,738
HAVE TO KEEP IN MIND THE

3013
01:50:35,738 --> 01:50:37,640
CHARACTERISTICS OF THE PATIENTS

3014
01:50:37,640 --> 01:50:41,610
FROM WHOM THESE MODELS WERE

3015
01:50:41,610 --> 01:50:41,844
DERIVED.

3016
01:50:41,844 --> 01:50:42,177
>> TOTALLY.

3017
01:50:42,177 --> 01:50:42,845
>> COMPLEXITY, AND
SECONDLY WE

3018
01:50:42,845 --> 01:50:44,446
ALSO HAVE TO CONSIDER THE

3019
01:50:44,446 --> 01:50:45,414
PHYSIOLOGICALITATE OF THE TUMOR,

3020
01:50:45,414 --> 01:50:48,617
NOT JUST THE TUMOR CELL STATES,

3021
01:50:48,617 --> 01:50:52,321
SO WE HAVE, I'M GOING ANDY,

3022
01:50:52,321 --> 01:50:53,822
AUSHI, AND THEN KAREN AND THEN I

3023
01:50:53,822 --> 01:50:55,691
WILL GO TO OTHER HAND FIST WE

3024
01:50:55,691 --> 01:51:00,663
HAVE TIME NSO JUST TO SORT OF GO

3025
01:51:00,663 --> 01:51:03,165
OFF OF THAT POINT, THESE ARE

3026
01:51:03,165 --> 01:51:04,233
SUCH VALUABLE PATIENTS FROM

3027
01:51:04,233 --> 01:51:05,401
PEASHT ANDS THIS IS AN

3028
01:51:05,401 --> 01:51:10,039
OPPORTUNITY ALSO TO BE PROFILING

3029
01:51:10,039 --> 01:51:10,873
PRECANCKERS OR NORMAL CONSENT

3030
01:51:10,873 --> 01:51:12,841
PATIENTS SO WE CAN REALLY USE

3031
01:51:12,841 --> 01:51:16,912
THESE AS MODELS FOR PREVENTIONS

3032
01:51:16,912 --> 01:51:21,550
AS WELL. 

3033
01:51:21,550 --> 01:51:22,251
>> SO ABSOLUTELY AND THE
REASON

3034
01:51:22,251 --> 01:51:25,187
I THINK THAT WOULD BE IMPORTANT

3035
01:51:25,187 --> 01:51:26,522
IN LIKE IN ANY EXPERIMENT YOU DO

3036
01:51:26,522 --> 01:51:28,590
IN THE LAB, IT'S THE CONTROLS

3037
01:51:28,590 --> 01:51:30,559
THAT ARE MORE IMPORTANT THAN THE

3038
01:51:30,559 --> 01:51:34,163
EXPERIMENT AND SO, WHAT YOU

3039
01:51:34,163 --> 01:51:37,599
WOULD LIKE TO FIND ARE MAYBE

3040
01:51:37,599 --> 01:51:39,068
EXTREME DEPENDENCIES THAT MIGHT

3041
01:51:39,068 --> 01:51:42,471
OCCUR IN A FULL CANCER AND MIGHT

3042
01:51:42,471 --> 01:51:44,106
BE JUST NASCENT IN THE EARLY

3043
01:51:44,106 --> 01:51:48,210
TUMOR AND MAYBE MISSING IN THE

3044
01:51:48,210 --> 01:51:48,444
NORMAL.

3045
01:51:48,444 --> 01:51:50,979
SO DEPENDING ON THE CANCER TYPE

3046
01:51:50,979 --> 01:51:51,680
WE CHOOSE, RIGHT?

3047
01:51:51,680 --> 01:51:53,582
WE MAY OR MAY NOT HAVE ACCESS TO

3048
01:51:53,582 --> 01:51:57,720
THOSE, BUT IF THERE ARE THAT

3049
01:51:57,720 --> 01:52:02,024
WOULD BE A GOOD SET POINT FOR

3050
01:52:02,024 --> 01:52:03,225
THE MODEL BUILDING EMPLOY NYEAH,

3051
01:52:03,225 --> 01:52:04,760
I WANT TO GIVE ALEX THE

3052
01:52:04,760 --> 01:52:06,028
OPPORTUNITY TO MAKE HIS COMMENT

3053
01:52:06,028 --> 01:52:06,729
AS WELL.

3054
01:52:06,729 --> 01:52:08,731
NEXT I ARKPOLOGYIZE I WILL MAKE

3055
01:52:08,731 --> 01:52:12,000
THIS BRIEF, QUICKLY IN RESPONSE

3056
01:52:12,000 --> 01:52:13,302
TO YOUR QUESTION TREY, THE REAL

3057
01:52:13,302 --> 01:52:17,373
GOAL IS TO UNDERSTAND HOW

3058
01:52:17,373 --> 01:52:18,674
MULTIPLE DEFINITE TRANSIC

3059
01:52:18,674 --> 01:52:19,475
FACTORS INTEGRATE TO DEFINE

3060
01:52:19,475 --> 01:52:21,110
STATES AND THINKING ABOUT WHERE

3061
01:52:21,110 --> 01:52:22,277
THE GENETIC SYSTEM IMPORTANT AND

3062
01:52:22,277 --> 01:52:23,345
NOT IMPORTANT IS CRITICAL AND I

3063
01:52:23,345 --> 01:52:26,181
CAN GIVE YOU EXAMPLES OF PDAC,

3064
01:52:26,181 --> 01:52:27,649
WHERE AMPLIFICATION OF A

3065
01:52:27,649 --> 01:52:28,951
PARTICULAR TRANSCRIPTION FACTOR

3066
01:52:28,951 --> 01:52:30,552
WALKS INTO A STATE AND OTHER

3067
01:52:30,552 --> 01:52:31,653
PLACES WHERE IT DOESN'T MATTER.

3068
01:52:31,653 --> 01:52:33,389
THE NICE THING IS THERE ARE BEEN

3069
01:52:33,389 --> 01:52:34,990
ALL THESE FUNCTION TOOLS THAT WE

3070
01:52:34,990 --> 01:52:36,525
BROUGHT UP THAT PUT US IN A

3071
01:52:36,525 --> 01:52:37,960
POSITION TO START SYSTEMATICALLY

3072
01:52:37,960 --> 01:52:40,195
TESTING THOSE SO NEXT TIME

3073
01:52:40,195 --> 01:52:42,731
YOU'RE ABLE TO TALK THROUGH THIS

3074
01:52:42,731 --> 01:52:45,467
BUT THINGS LIKE OVEREXPRESSION

3075
01:52:45,467 --> 01:52:46,769
SCREENS WHERE WOE HAVE ORGS

3076
01:52:46,769 --> 01:52:48,504
WHERE THEY COPY VARIANTS OR OVER

3077
01:52:48,504 --> 01:52:50,539
USE MY DRIVE US IN THEITATES,

3078
01:52:50,539 --> 01:52:52,107
REALLY COOL KREENS CAN YOU DO

3079
01:52:52,107 --> 01:52:54,777
THERE SAME THING WITH CRISPR

3080
01:52:54,777 --> 01:52:57,846
PROTEIN COMPLEX TURBATIONS AND

3081
01:52:57,846 --> 01:53:00,349
INTRODUCE MUTATIONS INTO MODELS

3082
01:53:00,349 --> 01:53:02,184
AND USE KREENING CAPABILITIES TO

3083
01:53:02,184 --> 01:53:04,520
SEE WHICH ARE DRIVING THESE

3084
01:53:04,520 --> 01:53:04,753
STATES.

3085
01:53:04,753 --> 01:53:06,388
AND THE WAY WE THINK ABOUT

3086
01:53:06,388 --> 01:53:09,925
GETTING SUPPORT FOR THIS, THE IN

3087
01:53:09,925 --> 01:53:10,859
SOME PLACES, THE COMBINATION

3088
01:53:10,859 --> 01:53:12,394
HELPS US GET A BETTER YOB CORPS

3089
01:53:12,394 --> 01:53:13,462
OF FIGURING OUT WHICH

3090
01:53:13,462 --> 01:53:14,763
COMBINATIONS TO USE SO WE HAVE

3091
01:53:14,763 --> 01:53:16,432
PAPER THAT WE JUST DREW ON

3092
01:53:16,432 --> 01:53:19,201
BIOARCHIVE THAT YOU SHOW IF YOU

3093
01:53:19,201 --> 01:53:21,303
COMBINE A BCR ENABLED INHIBITOR,

3094
01:53:21,303 --> 01:53:22,838
WITH SOMETHING TARGETING A

3095
01:53:22,838 --> 01:53:23,672
DISTINCT CELL PATHWAY, CAN YOU

3096
01:53:23,672 --> 01:53:26,442
DID A BETTER JOB OF DRIVING

3097
01:53:26,442 --> 01:53:27,376
REMISSION THAN USING 2 DIFFERENT

3098
01:53:27,376 --> 01:53:29,144
DRUGS THAT TARGET THE BCR ABLE

3099
01:53:29,144 --> 01:53:31,013
AND YOU KNOW THAT MIGHT SOUND

3100
01:53:31,013 --> 01:53:31,647
INTERESTING BUT WHAT'S REALLY

3101
01:53:31,647 --> 01:53:33,348
INTERESTING IS THAT THE RIGHT

3102
01:53:33,348 --> 01:53:34,016
COMBINATION DEPENDS UPON THE

3103
01:53:34,016 --> 01:53:37,052
STATE OF THE MODEL AND SO, HAPPY

3104
01:53:37,052 --> 01:53:38,687
TO TALK ABOUT MORE AND I WOULD

3105
01:53:38,687 --> 01:53:39,955
SAY PHYSIOLOGY IN THE SECOND

3106
01:53:39,955 --> 01:53:41,056
QUESTION WE CAME YOU UP AND

3107
01:53:41,056 --> 01:53:42,224
SOMETHING WE HAVE TO MODEL AS

3108
01:53:42,224 --> 01:53:43,592
WELL.

3109
01:53:43,592 --> 01:53:45,227
THERE ARE LOTS OF DARK THINGS

3110
01:53:45,227 --> 01:53:47,496
THAT NORMALLY WE DON'T THINK

3111
01:53:47,496 --> 01:53:49,965
ABOUT LIKE OXYGEN,

3112
01:53:49,965 --> 01:53:50,899
CONCENTRATIONS, RETENTIONS,

3113
01:53:50,899 --> 01:53:52,034
METABOLITES AND THE LIKE AND WE

3114
01:53:52,034 --> 01:53:53,469
HAVE TO DO MORE WORKING THROUGH

3115
01:53:53,469 --> 01:53:55,904
THIS, I WOULD SAY MANY OF YOU

3116
01:53:55,904 --> 01:53:57,105
ARE AWARE, INCREDIBLE ADVANCES

3117
01:53:57,105 --> 01:53:59,174
IN AI AND THIS GIVES US A GREAT

3118
01:53:59,174 --> 01:54:01,443
OPPORTUNITY NOT JUST TO ANALYZE

3119
01:54:01,443 --> 01:54:02,945
DATA THAT EXISTS BUT TO CREATE A

3120
01:54:02,945 --> 01:54:04,379
LAB IN THE LOOP ARCHITECTURE

3121
01:54:04,379 --> 01:54:05,347
WHERE WE CAN ACTUALLY THINK

3122
01:54:05,347 --> 01:54:07,182
ABOUT WHAT SPRPTS WE SHOULD DO

3123
01:54:07,182 --> 01:54:08,851
TO MAP OUT DIFFERENT SPACES WE

3124
01:54:08,851 --> 01:54:10,252
HAVE YET TO EXPLORE, SO THERE'S

3125
01:54:10,252 --> 01:54:12,221
A LOT WE CAN DO BUT I THINK AS

3126
01:54:12,221 --> 01:54:14,490
MUCH AS WE'VE DONE PROFILES IN

3127
01:54:14,490 --> 01:54:19,228
THE PAST, THIS IDEA OF FUNCTION,

3128
01:54:19,228 --> 01:54:21,129
TESTING MODELS, WHEN AND WHERE

3129
01:54:21,129 --> 01:54:22,264
THESE FACTORS ARE REEL KEEPSAKES

3130
01:54:22,264 --> 01:54:25,167
VAPT IS WHAT WE NEED FOR TRANS8

3131
01:54:25,167 --> 01:54:26,468
HOURSING INCREDIBLE TECHNOLOGIES

3132
01:54:26,468 --> 01:54:27,870
INTO INTERVENTIONS FOR PATIENTS

3133
01:54:27,870 --> 01:54:29,171
NTHANKS IN THE INTEREST OF TIME

3134
01:54:29,171 --> 01:54:32,241
WE WILL DO THESE LAST 2

3135
01:54:32,241 --> 01:54:32,808
QUESTIONS.

3136
01:54:32,808 --> 01:54:34,343
WE HAVE ASHI AND KAREN.

3137
01:54:34,343 --> 01:54:36,178
>> THANK YOU VERY MUCH, WE
HAVE

3138
01:54:36,178 --> 01:54:38,180
A SAYING MOO MY LAB THAT NO

3139
01:54:38,180 --> 01:54:40,749
TUMOR IS AN ISLAND AND WE HAVE

3140
01:54:40,749 --> 01:54:41,683
WONDERFUL TECHNOLOGIES AND

3141
01:54:41,683 --> 01:54:43,785
DEVELOPING FOR VERY TUMOR

3142
01:54:43,785 --> 01:54:44,119
CENTERED.

3143
01:54:44,119 --> 01:54:46,321
>> CAN YOU HEAR THE MIC
CLOSER.

3144
01:54:46,321 --> 01:54:47,956
>> SURE, REQUEST YOU HEAR
ME

3145
01:54:47,956 --> 01:54:48,690
BETTER NOW?

3146
01:54:48,690 --> 01:54:49,258
NYES.

3147
01:54:49,258 --> 01:54:50,559
>> AND THE ORGANIZATIONSA
ANOIDS

3148
01:54:50,559 --> 01:54:52,327
AND I LOOKEDDA THE AT THEM

3149
01:54:52,327 --> 01:54:54,329
THEY'RE NOT TAKING INTO ACCOUNT

3150
01:54:54,329 --> 01:54:56,098
THE STROMAL, THE FIBROBLAST, THE

3151
01:54:56,098 --> 01:54:56,698
ENDOTHELIAL, I UNDERSTAND YOU

3152
01:54:56,698 --> 01:54:59,001
CAN'T DO ALL OF THAT, AND I'M

3153
01:54:59,001 --> 01:55:00,969
JUST A LITTLE CURIOUS, BECAUSE

3154
01:55:00,969 --> 01:55:03,005
WE SEE EVEN WITH TARGETED

3155
01:55:03,005 --> 01:55:05,541
THERAPY THE HOST MATTERS, AGE

3156
01:55:05,541 --> 01:55:06,174
MATTERS, SEX MATTERS.

3157
01:55:06,174 --> 01:55:07,342
>> RIGHT, THAT WAS 1 OF
THE

3158
01:55:07,342 --> 01:55:09,645
SLIDES I TOOK OUT FOR THE

3159
01:55:09,645 --> 01:55:10,679
INTEREST OF TIME.

3160
01:55:10,679 --> 01:55:12,514
ABSOLUTELY HAVE A SLIDE OF

3161
01:55:12,514 --> 01:55:13,815
SIGNALS COMING FROM THE

3162
01:55:13,815 --> 01:55:16,018
MICROENVIRONMENT, I THINK THAT

3163
01:55:16,018 --> 01:55:19,121
ALEX SHOWED YOU YOU KNOW 1

3164
01:55:19,121 --> 01:55:21,557
SIGNAL DGP BETA COMING FROM THE

3165
01:55:21,557 --> 01:55:22,691
MICROENVIRONMENT FROM THE

3166
01:55:22,691 --> 01:55:25,928
STROMA, THAT HE CAN MODEL AND

3167
01:55:25,928 --> 01:55:28,897
SEE JUST WHAT YOU'RE TALKING

3168
01:55:28,897 --> 01:55:29,097
ABOUT.

3169
01:55:29,097 --> 01:55:31,266
SO IF IT'S A CYTOKINE WE CAN ADD

3170
01:55:31,266 --> 01:55:32,901
IT, IF IT'S ANOTHER CELL TYPE

3171
01:55:32,901 --> 01:55:34,436
THERE'S LOTS OF PAPERS OUT THERE

3172
01:55:34,436 --> 01:55:35,871
NOW WHERE PEOPLE ARE DOING MIXED

3173
01:55:35,871 --> 01:55:37,706
CULTURES AND I THINK THAT'S VERY

3174
01:55:37,706 --> 01:55:38,106
IMPORTANT.

3175
01:55:38,106 --> 01:55:40,842
CAN YOU EVEN MIX IN IMMUNE

3176
01:55:40,842 --> 01:55:42,744
CELLS, WE WOULD HAVE TO AGAIN,

3177
01:55:42,744 --> 01:55:43,412
THERE'S ELABORATE PLAN THAGOREAN

3178
01:55:43,412 --> 01:55:46,515
WOULD HAVE TO GO INTO THIS, TO

3179
01:55:46,515 --> 01:55:49,251
HAVE THOSE MATCHED FROM THE SAME

3180
01:55:49,251 --> 01:55:52,220
PATIENT BUT IT'S DOABLE AND

3181
01:55:52,220 --> 01:55:52,921
WORTH DOING, OKAY?

3182
01:55:52,921 --> 01:55:56,992
>>  OKAY, SO, WE HAVE
KAREN I

3183
01:55:56,992 --> 01:55:58,293
WANT TO RESPECT THE VIRTUAL ROOM

3184
01:55:58,293 --> 01:56:00,696
AS WELL SO I WILL ALLOW SYLVIA

3185
01:56:00,696 --> 01:56:02,864
TO ASK HER QUESTION BUT LET'S GO

3186
01:56:02,864 --> 01:56:04,199
KAREN FIRST.

3187
01:56:04,199 --> 01:56:07,836
>> THANK YOU LOU AND ALEX
SO

3188
01:56:07,836 --> 01:56:08,670
MUCH, VERY EXCITING INFORMATION

3189
01:56:08,670 --> 01:56:11,106
AND WE KNOW THAT THE TCGA FOR

3190
01:56:11,106 --> 01:56:12,975
EXAMPLE WAS BEHIND IN TERMS OF

3191
01:56:12,975 --> 01:56:15,410
DIVERSITY FROM SAMPLE FROM ANN

3192
01:56:15,410 --> 01:56:17,012
CESTERAL STANDPOINT, IT'S

3193
01:56:17,012 --> 01:56:18,647
CATCHING UP WHICH WAS GREAT, BUT

3194
01:56:18,647 --> 01:56:20,082
TO YOUR LAST POINT IT WOULD BE

3195
01:56:20,082 --> 01:56:22,517
HELPFUL TO KNOW OF THE HCMI, CAN

3196
01:56:22,517 --> 01:56:25,053
YOU TALK ABOUT THE ANCESTRY OF

3197
01:56:25,053 --> 01:56:26,021
THOSE SAMPLES BECAUSE AGAIN

3198
01:56:26,021 --> 01:56:26,822
ENVIRONMENT DOES MATTER, THAT

3199
01:56:26,822 --> 01:56:29,157
WOULD BE IMPORTANT BUT ALSO

3200
01:56:29,157 --> 01:56:31,126
ALEX, I WONDER IF BECAUSE THE

3201
01:56:31,126 --> 01:56:34,796
TCGA DOES LOOK AT METHYLATION,

3202
01:56:34,796 --> 01:56:36,331
DID THAT--DOES METHYLATION

3203
01:56:36,331 --> 01:56:37,165
STATUS IMPACT PROTURBATION AND

3204
01:56:37,165 --> 01:56:39,434
HAVE YOU LOOKEDDA THE DIFFERENCE

3205
01:56:39,434 --> 01:56:41,770
IN THAT ANCESTRY MIGHT MAKE.

3206
01:56:41,770 --> 01:56:42,604
>> SO, THANKS.

3207
01:56:42,604 --> 01:56:44,106
>> ABSOLUTELY SO WE'RE
LIKE MANY

3208
01:56:44,106 --> 01:56:47,409
PROJECTS NOT WHERE WE NEED TO

3209
01:56:47,409 --> 01:56:48,010
BE.

3210
01:56:48,010 --> 01:56:51,213
SO WE'RE JUST A LITTLE SHY OF

3211
01:56:51,213 --> 01:56:56,752
10% FROM AFRICAN AMERICAN IN THE

3212
01:56:56,752 --> 01:56:58,220
HCMI COLLECTION, BUT WE

3213
01:56:58,220 --> 01:57:00,589
DELIBERATELY HAVE MADE A PUSH

3214
01:57:00,589 --> 01:57:04,393
WITH EXTRA FUNDING FROM THE NCI

3215
01:57:04,393 --> 01:57:06,561
EQUITY COMMITTEE TO MAKE NEW

3216
01:57:06,561 --> 01:57:12,267
MODELS THAT ARE IN DEVELOPMENT

3217
01:57:12,267 --> 01:57:12,968
FROM PATIENTS UNDERREPRESENTED

3218
01:57:12,968 --> 01:57:15,070
AND THAT IS COMPLETELY A FOCUS

3219
01:57:15,070 --> 01:57:18,707
OF OUR OURS, I THINK AS YOU

3220
01:57:18,707 --> 01:57:22,144
ALLUDE TO THERE CAN BE PROFOUND

3221
01:57:22,144 --> 01:57:26,314
EPIGENETIC CHAIVENLGS THAT MAY

3222
01:57:26,314 --> 01:57:27,349
COME FROM METHYLATION THAT MAY

3223
01:57:27,349 --> 01:57:29,584
AND THOSE COULD BE HIGHLY

3224
01:57:29,584 --> 01:57:29,885
STABLE.

3225
01:57:29,885 --> 01:57:32,320
IT'S AMAZING HOW STABLE

3226
01:57:32,320 --> 01:57:37,192
METHYLATION PATTERNS ARE IN CELL

3227
01:57:37,192 --> 01:57:38,293
CULTURE SO I COMPLETELY AGREE

3228
01:57:38,293 --> 01:57:40,028
WITH YOU AND WE WILL BE

3229
01:57:40,028 --> 01:57:41,063
OBVIOUSLY PROFILING THE

3230
01:57:41,063 --> 01:57:42,431
METHYLATION STATUS AND IT COULD

3231
01:57:42,431 --> 01:57:44,399
MAKE A BIG DIFFERENCE.

3232
01:57:44,399 --> 01:57:45,267
>> LET'S DO THIS LAST
QUESTION

3233
01:57:45,267 --> 01:57:46,968
OR WE'RE GOING TO LOSE OUR

3234
01:57:46,968 --> 01:57:47,202
BREAK.

3235
01:57:47,202 --> 01:57:48,403
>> THANK YOU SO MUCH FOR
THE

3236
01:57:48,403 --> 01:57:48,704
OPPORTUNITY.

3237
01:57:48,704 --> 01:57:52,841
I DON'T HAVE A QUESTION, JUST 2

3238
01:57:52,841 --> 01:57:53,241
COMMENTS.

3239
01:57:53,241 --> 01:57:55,310
TD 50 COMMENT IS I FIND THESE

3240
01:57:55,310 --> 01:57:55,944
PRESENTATIONS REALLY INSPIRING

3241
01:57:55,944 --> 01:57:58,814
AND I HAVE TO SAY I REALLY WANT

3242
01:57:58,814 --> 01:58:00,348
TO THANK THE NCI FOR

3243
01:58:00,348 --> 01:58:02,284
BRINGINGITOUS WHERE WE ARE TODAY

3244
01:58:02,284 --> 01:58:03,952
BECAUSE IT REALLY TO ME SPEAKS

3245
01:58:03,952 --> 01:58:05,687
TO THE CANCER SYSTEMS BIOLOGY

3246
01:58:05,687 --> 01:58:10,926
PROGRAM AND THE WORK THAT DI NA

3247
01:58:10,926 --> 01:58:13,395
SINGER AT THE NCI LEADERSHIP

3248
01:58:13,395 --> 01:58:15,030
CREATED 20 YEARS AGO WITH THIS

3249
01:58:15,030 --> 01:58:16,631
CONSORTIUM SO I FEEL LIKE THIS

3250
01:58:16,631 --> 01:58:18,767
IS 1 EXAMPLE OF HOW THAT WORK

3251
01:58:18,767 --> 01:58:19,534
HAS REALLY MATURED.

3252
01:58:19,534 --> 01:58:21,870
AND THE OTHER 1 IS THAT I REALLY

3253
01:58:21,870 --> 01:58:26,842
THINK THIS IDEA OF A FUNCTIONAL

3254
01:58:26,842 --> 01:58:28,343
TCGA IS FANTASTIC--BUT AS YOU

3255
01:58:28,343 --> 01:58:29,377
DEVELOP THE IDEA REALLY KEEP,

3256
01:58:29,377 --> 01:58:31,580
YOU KNOW THESE ARK I MIND SET

3257
01:58:31,580 --> 01:58:32,881
AND DATA SCIENCE IN MIND.

3258
01:58:32,881 --> 01:58:36,218
THERE'S A LOT OF, YOU KNOW SORT

3259
01:58:36,218 --> 01:58:38,987
OF GPT MODELS AROUND CANCER AND

3260
01:58:38,987 --> 01:58:40,856
BIOLOGY, SORT OF LEVERAGING, YOU

3261
01:58:40,856 --> 01:58:43,024
KNOW THAT EXISTING DATA THAT IS

3262
01:58:43,024 --> 01:58:44,059
ALREADY OUT THERE, AND LAYERING

3263
01:58:44,059 --> 01:58:46,661
ON TOP OF THAT, I THINK IS

3264
01:58:46,661 --> 01:58:51,266
IMPORTANT AS YOU BELL OUT ANY

3265
01:58:51,266 --> 01:58:52,634
INITIATIVATIVE AT THIS SCALE.

3266
01:58:52,634 --> 01:58:57,706
>> ALEX DID YOU WANT THE
LAST

3267
01:58:57,706 --> 01:58:58,240
WORD?

3268
01:58:58,240 --> 01:59:03,812
>> YOU'RE ON MUTE. 

3269
01:59:03,812 --> 01:59:04,613
>> YOU'RE ON MUTE.

3270
01:59:04,613 --> 01:59:09,584
MI WAS TRYING TO--I HAD BEEN

3271
01:59:09,584 --> 01:59:12,754
SHUT OFF BY THE ORKNIZNERS, I

3272
01:59:12,754 --> 01:59:14,156
100 PERCENT AGREE WE NEED TO

3273
01:59:14,156 --> 01:59:16,224
BETTER UNDERSTAND THE ROLE OF

3274
01:59:16,224 --> 01:59:17,192
DIVERSITY AND ANCESTRY AND

3275
01:59:17,192 --> 01:59:18,360
PUTTING THOSE THINGS FORWARD AND

3276
01:59:18,360 --> 01:59:20,462
I THINK EACH MORE THAN THAT WE

3277
01:59:20,462 --> 01:59:22,764
HAVE TO DO A BETTER YOB CORPS OF

3278
01:59:22,764 --> 01:59:23,832
ENABLING THE SCIENTIST TO BE

3279
01:59:23,832 --> 01:59:25,033
PART OF THESE CONVERSATIONS AND

3280
01:59:25,033 --> 01:59:26,568
THINKING ABOUT THE KINDS OF DATA

3281
01:59:26,568 --> 01:59:29,070
AND QUESTIONS WE SHOULD BE

3282
01:59:29,070 --> 01:59:30,372
ASKING, AND SO, I'M A BIG

3283
01:59:30,372 --> 01:59:32,107
BELIEVER THAT YES WE NEED MORE

3284
01:59:32,107 --> 01:59:33,575
DIVERSITY IN OUR PROFILING IN

3285
01:59:33,575 --> 01:59:34,943
TERMS OF SAMPLES BUT WE ALSO

3286
01:59:34,943 --> 01:59:36,511
MEDE DIVERSITY IN THE TERMS OF

3287
01:59:36,511 --> 01:59:37,412
PEOPLE THAT ARE ACTUALLY

3288
01:59:37,412 --> 01:59:38,513
GENERATING THE DAILY BASIS AT

3289
01:59:38,513 --> 01:59:40,615
WHICH THEY WILL BE CATEGORY AND

3290
01:59:40,615 --> 01:59:41,483
THE METHYLATION TIES TIGHTLY

3291
01:59:41,483 --> 01:59:42,984
INTO A LOT OF THINGS WE BEFORE

3292
01:59:42,984 --> 01:59:46,555
THINKING ABOUT IN TERMS OF

3293
01:59:46,555 --> 01:59:47,355
GENETICS, RNA THAT WE'RE TALKING

3294
01:59:47,355 --> 01:59:48,657
ABOUT APPROXIMATE TREY AND I

3295
01:59:48,657 --> 01:59:50,425
THINK ABOUT IT AS PLASTICITY AND

3296
01:59:50,425 --> 01:59:52,260
HOW MUCH YOU KNOW CELLS CAN

3297
01:59:52,260 --> 01:59:53,795
CHANGE THEIR STATES GIVEN THE

3298
01:59:53,795 --> 01:59:55,530
GENETICS TO RESPOND TO THERAPY

3299
01:59:55,530 --> 01:59:56,598
AND THAT'S WHERE METHYLATION

3300
01:59:56,598 --> 01:59:56,865
COMES IN.

3301
01:59:56,865 --> 02:00:00,969
I WILL GIVE YOU THE LAST WORD.

3302
02:00:00,969 --> 02:00:01,369
>> GREAT.

3303
02:00:01,369 --> 02:00:05,574
JUST IN RESPONSE TO SYLVIA, THE

3304
02:00:05,574 --> 02:00:07,909
WHOLE IDEA THAT TREY HAS

3305
02:00:07,909 --> 02:00:09,511
IMPLEMENTED AND OTHERS ARE

3306
02:00:09,511 --> 02:00:11,446
WORKING ON IS THAT THESE AI

3307
02:00:11,446 --> 02:00:14,916
MODELS ARE BASED ON A FRAMEWORK

3308
02:00:14,916 --> 02:00:17,552
OF WHAT BIOLOGY IS AND BY

3309
02:00:17,552 --> 02:00:19,487
CONSTRAINING AI IN THAT WAY, YOU

3310
02:00:19,487 --> 02:00:21,790
DON'T IMET JUST RANDOM MODELS

3311
02:00:21,790 --> 02:00:23,992
THAT ARE BLACK BOX, BUT YOU

3312
02:00:23,992 --> 02:00:25,327
UNDERSTAND WHY THE MODELS ARE

3313
02:00:25,327 --> 02:00:27,429
WORKING, THAT'S WHERE WE NEED TO

3314
02:00:27,429 --> 02:00:28,830
GO.

3315
02:00:28,830 --> 02:00:29,264
>> GREAT.

3316
02:00:29,264 --> 02:00:33,435
FANTASTIC PRESENTATION, GREAT

3317
02:00:33,435 --> 02:00:33,902
DISCUSSION.

3318
02:00:33,902 --> 02:00:34,836
THANKS LOU AND ALEX.

3319
02:00:34,836 --> 02:00:38,206
>> THANK YOU ALL FOR
HAVING ME.

3320
02:00:38,206 --> 02:00:40,542
>> OKAY, GREAT, SO WE NOW
HAVE A

3321
02:00:40,542 --> 02:00:46,081
ROUGHLY 12 MINUTE BREAK. 

3322
02:00:46,081 --> 02:00:48,841
BE BACK AT 10:43

3323
02:00:48,841 --> 02:00:51,744
OKAY, NEXT ON OUR AGENDA WILL

3324
02:00:51,744 --> 02:00:53,746
BE A PRESENTATION ENTITLED

3325
02:00:53,746 --> 02:00:54,313
NETWORK CI VIRTUAL CLINICAL

3326
02:00:54,313 --> 02:00:55,381
TRIALS OFFICE THAT WILL BE

3327
02:00:55,381 --> 02:01:00,339
BROUGHT TO US BY JIM DOROSHOW,

3328
02:01:00,339 --> 02:01:02,141
WHO IS THE NCI DIRECTOR FOR THE

3329
02:01:02,141 --> 02:01:08,147
TRI VISION OF CANCER TREATMENT

3330
02:01:08,147 --> 02:01:16,255
AND DIAGNOSE. AND AUGUST OCHOA,

3331
02:01:16,255 --> 02:01:21,460
HE IS THE WITH LOUISIANA

3332
02:01:21,460 --> 02:01:22,194
UNIVERSITY HEALTH SCIENCES

3333
02:01:22,194 --> 02:01:22,428
CENTER.

3334
02:01:22,428 --> 02:01:24,697
SO I DIDN'T MEAN >>  THANK
YOU

3335
02:01:24,697 --> 02:01:25,498
AND THANK YOU.

3336
02:01:25,498 --> 02:01:26,899
I'M SO GRATEFUL THE SLIDE IS UP

3337
02:01:26,899 --> 02:01:28,467
SO WE CAN MOVE RIGHT ALONG, SO

3338
02:01:28,467 --> 02:01:32,004
THANK YOU SO MUCH FOR THE CHANCE

3339
02:01:32,004 --> 02:01:34,073
TO PRESENT THIS REALLY NEW PILOT

3340
02:01:34,073 --> 02:01:36,509
PROGRAM CALLED THE NCI'S VIRTUAL

3341
02:01:36,509 --> 02:01:38,077
CLINICAL TRIALS OFFICE AND MY

3342
02:01:38,077 --> 02:01:39,879
OUTLINE IS FIRST TO HELP YOU

3343
02:01:39,879 --> 02:01:41,580
UNDERSTAND THE RATIONAL WE HAD

3344
02:01:41,580 --> 02:01:43,816
FOR TEABING THIS PILOT PROGRAM.

3345
02:01:43,816 --> 02:01:46,218
I GIVE YOU AN INITIAL

3346
02:01:46,218 --> 02:01:47,853
DESCRIPTION, INITIAL METRICS AND

3347
02:01:47,853 --> 02:01:49,555
IMPORTANTLY THE LESSONS LEARNED

3348
02:01:49,555 --> 02:01:51,857
FROM THE FIRST 4 OR 5 MONTHS,

3349
02:01:51,857 --> 02:01:53,192
THIS ACTIVITY, TALK ABOUT FUTURE

3350
02:01:53,192 --> 02:01:56,429
PLANS AND HAVE THE PLEASURE OF

3351
02:01:56,429 --> 02:01:57,930
INTRODUCING DR. OCHOA, WHO

3352
02:01:57,930 --> 02:01:59,565
REALLY IS GOING TO TELL YOU

3353
02:01:59,565 --> 02:02:01,767
ABOUT THE PREPILOT, PILOT OF

3354
02:02:01,767 --> 02:02:05,237
THIS ACTIVITY, AT THE GULF SOUTH

3355
02:02:05,237 --> 02:02:07,406
NCORP IN NEW ORLEANS.

3356
02:02:07,406 --> 02:02:09,408
SO THIS IS A SLIDE SOME OF YOU

3357
02:02:09,408 --> 02:02:10,810
HAVE SEEN BEFORE BUT I WANT TO

3358
02:02:10,810 --> 02:02:12,478
EMPHASIZE THAT YOU ALL KNOW WHAT

3359
02:02:12,478 --> 02:02:18,651
HAPPENED DURING THE PANDEMIC AND

3360
02:02:18,651 --> 02:02:21,620
IT'S IMPORTANT TO UNDERSTAND THE

3361
02:02:21,620 --> 02:02:23,389
ACCRUAL BUT MAJOR ISSUES ABOUT

3362
02:02:23,389 --> 02:02:26,459
ACTUALLY HIRING PEOPLE TO OPEN

3363
02:02:26,459 --> 02:02:27,626
STUDIES, HIRING PEOPLE, KEEPING

3364
02:02:27,626 --> 02:02:29,161
PEOPLE,A ROUND THAT WEREN'T

3365
02:02:29,161 --> 02:02:31,363
BOCHED BY INDUSTRY TO ACTUALLY

3366
02:02:31,363 --> 02:02:32,965
DO THE WORK OF THE DATA MANAGE

3367
02:02:32,965 --> 02:02:35,968
AM THAT WAS REQUIRED AND IN

3368
02:02:35,968 --> 02:02:37,837
FACT, AS YOU WILL SEE, CONTINUE

3369
02:02:37,837 --> 02:02:39,472
TO THIS DAY AND IN PARTICULAR,

3370
02:02:39,472 --> 02:02:41,574
WE ARE FACING MAJOR PROBLEMS IN

3371
02:02:41,574 --> 02:02:44,677
TERMS OF HAVING THE DATA

3372
02:02:44,677 --> 02:02:45,845
MANAGEMENT AND CRA SUPPORT TO

3373
02:02:45,845 --> 02:02:47,279
ACTUALLY KEEP THE TRIALS UP TO

3374
02:02:47,279 --> 02:02:49,181
DATE IN TERMS OF THE ACCRUAL

3375
02:02:49,181 --> 02:02:50,916
DATA GETTING INTO THE

3376
02:02:50,916 --> 02:02:51,550
APPROPRIATE DATABASES.

3377
02:02:51,550 --> 02:02:53,052
THIS CONTINUES TO BE A

3378
02:02:53,052 --> 02:02:58,991
SIGNIFICANT PROBLEM AND SO, WHEN

3379
02:02:58,991 --> 02:03:01,026
WE JUST TO IMIF YOU DATA, NO

3380
02:03:01,026 --> 02:03:02,328
SURPRISE WHAT HAPPENED IN 2020

3381
02:03:02,328 --> 02:03:03,829
BUT YOU WILL SEE THE NUMBERS

3382
02:03:03,829 --> 02:03:08,033
HAVE NOT FULLY RECOVERED THROUGH

3383
02:03:08,033 --> 02:03:11,303
BACK TO 19 LEVELS AND

3384
02:03:11,303 --> 02:03:12,238
SPECIFICALLY, WHAT'S IMPORTANT

3385
02:03:12,238 --> 02:03:14,206
IS THAT WE SEE THAT--WE SEE THE

3386
02:03:14,206 --> 02:03:18,477
DIP BUT YOU SEE THAT THE NCTN

3387
02:03:18,477 --> 02:03:21,447
ACCRUAL DID COME BACK.

3388
02:03:21,447 --> 02:03:22,148
PHARMA ACCRUAL DID COME BACK,

3389
02:03:22,148 --> 02:03:24,250
ABOUT YOU WE ARE IN A

3390
02:03:24,250 --> 02:03:26,318
SIGNIFICANT, I THINK A

3391
02:03:26,318 --> 02:03:27,486
SIGNIFICANT PROBLEM IN THAT WHAT

3392
02:03:27,486 --> 02:03:29,054
DRIVES A LOT OF WORK THAT GOES

3393
02:03:29,054 --> 02:03:33,592
ON IN THE CLINICAL TRIALS AND

3394
02:03:33,592 --> 02:03:36,028
CORRELATIVE SCIENCE ARENAS AND

3395
02:03:36,028 --> 02:03:37,296
INVESTIGATOR INITIATED TRIALS.

3396
02:03:37,296 --> 02:03:38,664
INVESTIGATOR INITIATED ARK

3397
02:03:38,664 --> 02:03:39,632
CREWAL AND GRANT SUPPORT TRIALS

3398
02:03:39,632 --> 02:03:42,735
HAVE NOT COME BACK AND THEY ARE

3399
02:03:42,735 --> 02:03:45,271
20-25% BELOW WHERE THEY WERE IN

3400
02:03:45,271 --> 02:03:48,274
2019 AND PREVIOUS YEARS AND WE

3401
02:03:48,274 --> 02:03:48,874
ARE SIGNIFICANTLY CONCERNED

3402
02:03:48,874 --> 02:03:52,077
ABOUT THAT AND SO, THAT CONCERN

3403
02:03:52,077 --> 02:03:53,045
WHICH HAS PERSISTED REALLY

3404
02:03:53,045 --> 02:04:00,986
STARTED US THINKING ABOUT A YEAR

3405
02:04:00,986 --> 02:04:07,092
AND HALF AGO I AND ROUTINELY,

3406
02:04:07,092 --> 02:04:07,793
AFTER THAT PRESENTATION, PEOPLE

3407
02:04:07,793 --> 02:04:09,261
CAME OUT TO ME, WHAT CAN YOU DO,

3408
02:04:09,261 --> 02:04:12,264
HOW CAN YOU HELP US, REALLY OUR

3409
02:04:12,264 --> 02:04:14,133
CLINICAL TRIALS OFFICES ARE

3410
02:04:14,133 --> 02:04:15,601
TERRIBLY EXPENSIVE, WE CAN'T

3411
02:04:15,601 --> 02:04:17,970
HIRE PEOPLE, WE'VE RAISED THE

3412
02:04:17,970 --> 02:04:18,704
SALARIES, STILL IT'S DIFFICULT

3413
02:04:18,704 --> 02:04:20,973
FINDING PEOPLE TO GET THE WORK

3414
02:04:20,973 --> 02:04:21,340
DONE.

3415
02:04:21,340 --> 02:04:24,743
SO I TARTED THINKING ABOUT

3416
02:04:24,743 --> 02:04:27,012
SOMETHING TO ME TO NOT BE CLEAR

3417
02:04:27,012 --> 02:04:29,081
TO THOSE HERE TODAY AND THAT IS

3418
02:04:29,081 --> 02:04:30,916
THAT FOR MANY YEARS, PART OF THE

3419
02:04:30,916 --> 02:04:32,885
ACTIVITY AT THE FED RICK

3420
02:04:32,885 --> 02:04:35,087
NATIONAL LAB, WHICH WAS FUNDED

3421
02:04:35,087 --> 02:04:39,024
BY THE NIAID, WAS REALLY A

3422
02:04:39,024 --> 02:04:41,660
PROGRAM TO SEND CRAs AND

3423
02:04:41,660 --> 02:04:43,729
RESEARCH NURSES TO AFRICA TO

3424
02:04:43,729 --> 02:04:47,399
AROUND THE COUNTRY FOR THE--ALL

3425
02:04:47,399 --> 02:04:48,367
OF THE ANTIVIRAL TRIALS THAT

3426
02:04:48,367 --> 02:04:51,337
WERE POPPED UP AND HAD TO BE

3427
02:04:51,337 --> 02:04:54,873
ACTIVATED VERY QUICKLY DURING IN

3428
02:04:54,873 --> 02:04:55,107
2020.

3429
02:04:55,107 --> 02:04:56,542
AND SO, BUT THOSE ACTIVITIES FOR

3430
02:04:56,542 --> 02:04:58,777
THE MOST PART ARE FOCUSED ARK

3431
02:04:58,777 --> 02:05:00,045
ROUND AUDITING TRIALS, NOT SO

3432
02:05:00,045 --> 02:05:02,381
MUCH IN DOING THE WORK OF

3433
02:05:02,381 --> 02:05:03,515
SCREENING AND DATA MANAGEMENT

3434
02:05:03,515 --> 02:05:04,750
AND SO AND SO, BUT THE FACT IS

3435
02:05:04,750 --> 02:05:07,052
IF YOU THINK ABOUT IT, IF YOU

3436
02:05:07,052 --> 02:05:08,754
CAN AUDIT A TRIAL, IT MEANS HAVE

3437
02:05:08,754 --> 02:05:10,856
YOU ACCESS TO RECORDS, RIGHT?

3438
02:05:10,856 --> 02:05:12,825
YOU HAVE ACCESS TO RECORS AND

3439
02:05:12,825 --> 02:05:15,127
YOU CAN DO DATA MANAGEMENT.

3440
02:05:15,127 --> 02:05:15,361
RIGHT?

3441
02:05:15,361 --> 02:05:17,096
AND FIRST THING I DID ABOUT A

3442
02:05:17,096 --> 02:05:18,631
YEAR AND HALF OR 2 YEARS AGO WAS

3443
02:05:18,631 --> 02:05:19,765
TO CALL THE INDIVIDUALS WHO ARE

3444
02:05:19,765 --> 02:05:21,800
IN CHARGE OF THIS PROGRAM FOR

3445
02:05:21,800 --> 02:05:23,702
NIAID AND SAY, WELL, OKAY, YOU

3446
02:05:23,702 --> 02:05:25,237
MUST HAVE GOTTEN ACCESS TO THE

3447
02:05:25,237 --> 02:05:27,906
EHRs, CAN YOU SEND ME A LIST

3448
02:05:27,906 --> 02:05:29,975
OF THE INSTITUTIONS WHERE THAT

3449
02:05:29,975 --> 02:05:31,844
WAS ACTUALLY POSSIBLE FOR THESE

3450
02:05:31,844 --> 02:05:32,911
VIRALS AND THEY SENT ME A LIST

3451
02:05:32,911 --> 02:05:35,347
AND IT WAS A LONG LIST, A LOT OF

3452
02:05:35,347 --> 02:05:36,515
YOUR INSTITUTIONS WERE ON THE

3453
02:05:36,515 --> 02:05:38,284
LIST, A LOT OF YOUR INSTITUTIONS

3454
02:05:38,284 --> 02:05:42,154
WERE NOT ON THE LIST, RIGHT IN

3455
02:05:42,154 --> 02:05:44,256
BUT I WAS I TOOK THAT DATA AS

3456
02:05:44,256 --> 02:05:45,924
WELL, AS A HALF FULL PERSPECTIVE

3457
02:05:45,924 --> 02:05:46,959
THAT THERE ARE MANY

3458
02:05:46,959 --> 02:05:48,027
ORGANIZATIONS THAT WOULD ARK LOW

3459
02:05:48,027 --> 02:05:49,428
THE GOVERNMENT TO LOOK AT THEIR

3460
02:05:49,428 --> 02:05:52,765
EHR AND SO COULD WE THINK ABOUT

3461
02:05:52,765 --> 02:05:54,800
DOING THIS TO ASSIST THE NCI

3462
02:05:54,800 --> 02:05:55,634
ASSOCIATED CANCER CENTERS AND

3463
02:05:55,634 --> 02:05:57,269
OUR OTHER SITES THAT PLAY A

3464
02:05:57,269 --> 02:05:59,705
CRITICAL ROLE IN ARK CREWAL AND

3465
02:05:59,705 --> 02:06:01,307
ACTUALLY THINK ABOUT HIRING

3466
02:06:01,307 --> 02:06:03,609
PEOPLE BUT NOT JUST FOR AUDITING

3467
02:06:03,609 --> 02:06:05,811
BUT TO HAVE IT TO UNDERTAKE A

3468
02:06:05,811 --> 02:06:07,880
WHOLE PORTFOLIO OF SERVICES THAT

3469
02:06:07,880 --> 02:06:09,715
YOUR CLINICAL TRIALS OFFICES

3470
02:06:09,715 --> 02:06:13,752
PROVIDE WHETHER IT'S SCREENING,

3471
02:06:13,752 --> 02:06:15,120
PROMOTING ENTRY, INFORMED

3472
02:06:15,120 --> 02:06:18,524
CONSENT AND HEALTH, DATA

3473
02:06:18,524 --> 02:06:20,592
MANAGEMENT ITSELF BUT A LOT

3474
02:06:20,592 --> 02:06:20,959
MORE.

3475
02:06:20,959 --> 02:06:22,161
COORDINATEDINATEING STUDY VISITS

3476
02:06:22,161 --> 02:06:24,463
FOR EXAMPLE, DOING REGULATORY

3477
02:06:24,463 --> 02:06:25,531
REPORT, ADVERSE EEIVET

3478
02:06:25,531 --> 02:06:26,565
REPORTING, EVERY PLACE AND I

3479
02:06:26,565 --> 02:06:28,000
WILL SAY THIS TWICE, IT TURNS

3480
02:06:28,000 --> 02:06:32,037
OUT THAT EACH INSTITUTION THERE

3481
02:06:32,037 --> 02:06:33,906
ARE A MENU OF ACTIVITIES THAT

3482
02:06:33,906 --> 02:06:35,074
NEEDED SUPPORT BUT EACH

3483
02:06:35,074 --> 02:06:38,644
INSTITUTION IS DIFFERENT ABOUT

3484
02:06:38,644 --> 02:06:40,279
WHAT IS MOST IMPORTANT AT THEIR

3485
02:06:40,279 --> 02:06:41,347
INTUITION AND WHAT THEY'RE

3486
02:06:41,347 --> 02:06:42,314
FINDING DIFFICULTY IN DOING SO

3487
02:06:42,314 --> 02:06:44,116
WHAT WE DID WAS TO DO A SURVEY

3488
02:06:44,116 --> 02:06:45,517
OF THE CANCER CENTERS TO FIND

3489
02:06:45,517 --> 02:06:46,919
OUT WELL, IS THIS REALLY A

3490
02:06:46,919 --> 02:06:50,723
PROBLEM, DO YOU NEED HELP IN

3491
02:06:50,723 --> 02:06:51,323
OVERWHELMING RESPONSE,

3492
02:06:51,323 --> 02:06:52,191
OVERWHELMING AREY SPONSE THAT

3493
02:06:52,191 --> 02:06:52,624
PEOPLE NEEDED HELP.

3494
02:06:52,624 --> 02:06:54,259
YOU KNOW THIS IS ABOUT A YEAR

3495
02:06:54,259 --> 02:06:57,830
AND A HALF AGO, SO WE DID ASK,

3496
02:06:57,830 --> 02:07:00,466
WE QUERIED FURTHER, WELL WHAT

3497
02:07:00,466 --> 02:07:02,000
SPECIFIC KINDS OF HELP WOULD YOU

3498
02:07:02,000 --> 02:07:04,903
NEED TO ENHANCE YOUR ACCRUAL FOR

3499
02:07:04,903 --> 02:07:07,072
UNDERSERVED POPULATIONS, RURAL

3500
02:07:07,072 --> 02:07:08,474
POPULATIONS TO NCTN TRIALS.

3501
02:07:08,474 --> 02:07:12,144
AND WE GOT BACK AND GIVE US AN

3502
02:07:12,144 --> 02:07:15,347
EXAMPLE OF JUST HOW DIRE THE

3503
02:07:15,347 --> 02:07:15,848
CIRCUMSTANCE WAS.

3504
02:07:15,848 --> 02:07:17,916
I'M NOT GOING TO DIVULGE THAT

3505
02:07:17,916 --> 02:07:19,551
INFORMATION, BUT IT WAS

3506
02:07:19,551 --> 02:07:21,387
SIGNIFICANT IN TERPS OF THE

3507
02:07:21,387 --> 02:07:24,223
NEEDS ACROSS THE BOARD

3508
02:07:24,223 --> 02:07:25,624
NATIONALLY AND SO, WE BASICALLY

3509
02:07:25,624 --> 02:07:27,760
WENT THROUGH A PRIORITIZATION

3510
02:07:27,760 --> 02:07:28,660
PROCESS FOCUSING ON WHAT

3511
02:07:28,660 --> 02:07:32,231
INSTITUTIONS AND MADE THE BEST

3512
02:07:32,231 --> 02:07:34,867
CASE OR SEVERE NEED IN THE

3513
02:07:34,867 --> 02:07:39,738
ABILITY TO ACCRUE PATIENTS FROM

3514
02:07:39,738 --> 02:07:41,140
UNDERSERVED SITUATIONS CHOSE 3

3515
02:07:41,140 --> 02:07:43,142
NCI DESIGNATED CANCER CENTERS, 2

3516
02:07:43,142 --> 02:07:48,981
OF WHICH ACTUALLY HAVE MINORITY

3517
02:07:48,981 --> 02:07:51,116
[INDISCERNIBLE] SO FOR THE

3518
02:07:51,116 --> 02:07:55,387
EINSTEIN, UNIVERSITY OF TEXAS,

3519
02:07:55,387 --> 02:07:57,022
CHOSE 3 NCORP SITES IN RURAL

3520
02:07:57,022 --> 02:07:59,324
SITES THAT WERE HAVING A LOT OF

3521
02:07:59,324 --> 02:08:00,926
DIFFICULT GETTING THEIR DATA

3522
02:08:00,926 --> 02:08:03,662
MANAGEMENT DONE AND DECIDED THAT

3523
02:08:03,662 --> 02:08:05,197
AFTER HAVING LOOKED AT MOST

3524
02:08:05,197 --> 02:08:06,598
INSTITUTIONS, WHERE WAS THE

3525
02:08:06,598 --> 02:08:07,299
OVERLAP IN THE CLINICAL TRIALS

3526
02:08:07,299 --> 02:08:10,035
THAT THEY WERE ALL   PERFORMING

3527
02:08:10,035 --> 02:08:13,205
SO WE COULD DO--DO A BETTER JOB

3528
02:08:13,205 --> 02:08:15,174
OF CENTRALIZING SUPPORT OF THOSE

3529
02:08:15,174 --> 02:08:17,276
ACTIVITIES AND FOCUS ON AN

3530
02:08:17,276 --> 02:08:19,244
INITIALY SET OF 12 OR 13

3531
02:08:19,244 --> 02:08:21,547
PROTOCOLS, AND WE'VE BEEN AT IT

3532
02:08:21,547 --> 02:08:23,182
FOR JUST OVER 4 MONTHS, THE

3533
02:08:23,182 --> 02:08:24,683
CANCERS JUST CAME ON ABOUT A

3534
02:08:24,683 --> 02:08:26,685
HONTH AND A HALF AGO AND I HAVE

3535
02:08:26,685 --> 02:08:28,720
TELL YOU I'VE BEEN OVERWHELMED

3536
02:08:28,720 --> 02:08:33,158
BY THE RESPONSE THAT UT UT SAN

3537
02:08:33,158 --> 02:08:34,326
ANTONIO, ISSUE WAS SCREENING,

3538
02:08:34,326 --> 02:08:35,894
THEY HAD PEOPLE TO DO DATA

3539
02:08:35,894 --> 02:08:37,696
MANAGEMENT, THEY DID NOT HAVE

3540
02:08:37,696 --> 02:08:41,066
ANYBODY TO HELP IN THE CLINIC

3541
02:08:41,066 --> 02:08:42,568
PROVIDING THE PHYSICIANS, SEEING

3542
02:08:42,568 --> 02:08:44,002
THE PATIENTS, THESE ARE THE

3543
02:08:44,002 --> 02:08:45,971
PROTOCOLS THAT YOUR PATIENT

3544
02:08:45,971 --> 02:08:47,105
MIGHT BE ELIGIBLE.

3545
02:08:47,105 --> 02:08:48,841
AND THEY SCREENED OVER 4000

3546
02:08:48,841 --> 02:08:52,177
PATIENTS IN ABOUT 4 AND HALF

3547
02:08:52,177 --> 02:08:55,848
MONTHS VIA THIS VIRTUAL

3548
02:08:55,848 --> 02:08:56,782
ACTIVITY, IDENTIFIED NOW CLOSE

3549
02:08:56,782 --> 02:08:59,451
TO ABOUT A HUNDRED PATIENTS,

3550
02:08:59,451 --> 02:09:00,686
PROTOCOL ELIGIBLE AND A FAWRTER

3551
02:09:00,686 --> 02:09:03,755
OF THOSE WILL BE MORE THAN IN

3552
02:09:03,755 --> 02:09:05,891
THE NCTN TRIALS THAT,'S JUST 3

3553
02:09:05,891 --> 02:09:07,292
PLACES, THE FIRST 3, AS YOU WILL

3554
02:09:07,292 --> 02:09:09,928
SEE IN A MINUTE, TRY TO COME TO

3555
02:09:09,928 --> 02:09:10,662
CONCLUSION, GET EVERYTHING SET

3556
02:09:10,662 --> 02:09:13,966
UP SO THAT THESE SURFACES CAN BE

3557
02:09:13,966 --> 02:09:14,900
PROVIDED THERE.

3558
02:09:14,900 --> 02:09:16,034
SO WHAT HAVEEE WE LEARNED, THIS

3559
02:09:16,034 --> 02:09:17,569
IS WHAT I WANTED TO SHARE WITH

3560
02:09:17,569 --> 02:09:18,971
YOU BECAUSE THIS A REALLY EARLY

3561
02:09:18,971 --> 02:09:22,174
STAGE OF THIS PILOT, BUT WE'VE

3562
02:09:22,174 --> 02:09:22,975
LEARNED A LOT.

3563
02:09:22,975 --> 02:09:27,179
SOME THINGS I HAD NO CONCEPT OF,

3564
02:09:27,179 --> 02:09:27,513
OKAY.

3565
02:09:27,513 --> 02:09:29,281
SO YES, EVERY PLACE IS DIFFERENT

3566
02:09:29,281 --> 02:09:31,450
IN TERMS OF MOUs SET UP, EVERY

3567
02:09:31,450 --> 02:09:32,684
PLACE IS A LITTLE BIT DIFFERENT

3568
02:09:32,684 --> 02:09:34,786
IN TERPS OF IT AND THEIR IT

3569
02:09:34,786 --> 02:09:37,189
SECURITY SO YOU HAVE TO LEARN

3570
02:09:37,189 --> 02:09:38,190
WHAT THE PRINCIPLE QUESTIONS

3571
02:09:38,190 --> 02:09:39,558
ARE, FOR THESE PLACES, I THINK

3572
02:09:39,558 --> 02:09:41,326
THE MORE WE DO THIS, THE MORE WE

3573
02:09:41,326 --> 02:09:43,562
LEARN WITH THE ENTIRE MENU OF

3574
02:09:43,562 --> 02:09:44,963
ISSUES ARE RELATED TO IT

3575
02:09:44,963 --> 02:09:46,398
SECURITY AND WE HAVE TO FOR ALL

3576
02:09:46,398 --> 02:09:48,500
OF THE PEOPLE THAT ARE GOING TO

3577
02:09:48,500 --> 02:09:49,868
PARTICIPATE, THEY HAVE TO GET

3578
02:09:49,868 --> 02:09:52,504
THE APPROPRIATE ASHES COUNTS IN

3579
02:09:52,504 --> 02:09:55,874
THE CTSU TO BE ABLE TO, THE

3580
02:09:55,874 --> 02:09:57,042
ORGANIZATION, OUR ORGANIZATION,

3581
02:09:57,042 --> 02:09:59,811
NCI FREDERICK, THE VIRTUAL, THE

3582
02:09:59,811 --> 02:10:02,347
STAFF, AND ALSO ALL OF THE FOLKS

3583
02:10:02,347 --> 02:10:05,384
ACTUALLY AT INDIVIDUAL SITES CAN

3584
02:10:05,384 --> 02:10:06,351
COLLABORATE WITH RESPECT TO THE

3585
02:10:06,351 --> 02:10:07,619
PARTICULAR TRIAL ANDS THE

3586
02:10:07,619 --> 02:10:08,420
PARTICULAR ACCRUAL.

3587
02:10:08,420 --> 02:10:10,522
I THINK PROBABLY THE BIGGEST

3588
02:10:10,522 --> 02:10:11,823
LESSON LEARNED AND I DON'T WANT

3589
02:10:11,823 --> 02:10:14,359
TO PICK ON EPIC PER SE, IT'S

3590
02:10:14,359 --> 02:10:15,761
JUST THE FIRST 6 SITES THAT WERE

3591
02:10:15,761 --> 02:10:18,864
CHOSEN ARE ALL EPIC SITES IS

3592
02:10:18,864 --> 02:10:21,667
THAT THIS IS A BIG DEAL, IN

3593
02:10:21,667 --> 02:10:24,069
GETTING ACCRUAL AND GETTING

3594
02:10:24,069 --> 02:10:27,272
ACCESS, AND AGAIN, WHAT I WANTED

3595
02:10:27,272 --> 02:10:29,708
TO SAY IS BASICALLY WHAT I

3596
02:10:29,708 --> 02:10:32,277
LEARNED THAT I WAS COMPLETELY

3597
02:10:32,277 --> 02:10:32,844
IGNORANT OF, RIGHT?

3598
02:10:32,844 --> 02:10:35,247
SO I WOULD GUESS THAT MOST OF

3599
02:10:35,247 --> 02:10:36,582
YOU WORK AT MAJOR ACADEMIC

3600
02:10:36,582 --> 02:10:38,517
MEDICAL CENTERS AND IF I WERE TO

3601
02:10:38,517 --> 02:10:40,586
PUT IT TO YOU AND YOU HAD TO

3602
02:10:40,586 --> 02:10:42,054
RAISE YOUR HAND, DO YOU THINK IT

3603
02:10:42,054 --> 02:10:44,690
WILL BE EASIER TO GET ACCESS TO

3604
02:10:44,690 --> 02:10:47,659
THE EHRs AT THE COMMUNITY

3605
02:10:47,659 --> 02:10:48,360
SITES OR ACADEMIC MEDICAL

3606
02:10:48,360 --> 02:10:50,562
CENTERS AND I'M WILLING TO BET

3607
02:10:50,562 --> 02:10:52,230
THE VAST MAJORITY OF YOU WOULD

3608
02:10:52,230 --> 02:10:57,970
SAY ACADEMIC MEDICAL CENTERS,

3609
02:10:57,970 --> 02:10:58,937
AND THAT'S WRONG.

3610
02:10:58,937 --> 02:10:59,137
OKAY.

3611
02:10:59,137 --> 02:11:00,772
THE ACADEMIC MEDICAL CENTERS

3612
02:11:00,772 --> 02:11:04,309
ACTUALLY OWN THEIR INSTANCE OF

3613
02:11:04,309 --> 02:11:05,611
EPIC, AND SO, SO THAT HAS NOT,

3614
02:11:05,611 --> 02:11:07,512
IT'S NOT THAT IT TAKES A SHORT

3615
02:11:07,512 --> 02:11:10,382
PERIOD OF TIME, BUT IF THE

3616
02:11:10,382 --> 02:11:11,116
UNIVERSITY OF KANSAS DECIDES

3617
02:11:11,116 --> 02:11:14,453
THAT IT WANTS TO PARTICIPATE IN

3618
02:11:14,453 --> 02:11:15,754
THIS ACTIVITY, THEN THERE CANCER

3619
02:11:15,754 --> 02:11:18,123
CENTER DIRECTOR CAN GO TO THE IT

3620
02:11:18,123 --> 02:11:20,726
SECURITY FOLKS AND IT HAPPENS,

3621
02:11:20,726 --> 02:11:20,959
RIGHT?

3622
02:11:20,959 --> 02:11:22,628
THE PROBLEM AND SOMETHING I HAD

3623
02:11:22,628 --> 02:11:26,264
NO CONCEPT OF, IS THAT AT

3624
02:11:26,264 --> 02:11:28,233
MANY--EASY TO DEAL WITH, VERY

3625
02:11:28,233 --> 02:11:31,570
SMALL PRACTICES THAT OWN SMALL

3626
02:11:31,570 --> 02:11:32,070
EHR SYSTEMS, RIGHT?

3627
02:11:32,070 --> 02:11:34,039
BECAUSE THEY OWN IT, IT'S FOR

3628
02:11:34,039 --> 02:11:36,108
THEIR BILLING, THEY WANT

3629
02:11:36,108 --> 02:11:40,512
ASSISTANCE, NO PROBLEM, BUT

3630
02:11:40,512 --> 02:11:41,546
INTERMEDIATE, HOSPITAL SYSTEMS

3631
02:11:41,546 --> 02:11:46,518
DON'T NECESSARILY BUY A FULL

3632
02:11:46,518 --> 02:11:48,286
INITANCE OF EPIC OR

3633
02:11:48,286 --> 02:11:49,888
[INDISCERNIBLE], IN ESSENCE THEY

3634
02:11:49,888 --> 02:11:51,189
LEASE FROM AN INTERMEDIARY

3635
02:11:51,189 --> 02:11:52,391
PROVIDER, THESE ACCESS TO THESE

3636
02:11:52,391 --> 02:11:56,695
MAJOR SYSTEMS AND SO, THE SITE

3637
02:11:56,695 --> 02:11:58,964
MAY BE 100% GUNG-HO TO

3638
02:11:58,964 --> 02:12:02,701
PARTICIPATE, EPIC SAYS, NOT OUR

3639
02:12:02,701 --> 02:12:03,068
PROBLEM, RIGHT?

3640
02:12:03,068 --> 02:12:04,102
, INTERMEDIARY THOUGH, WE HAVE

3641
02:12:04,102 --> 02:12:05,971
TO DEAL WITH THEIR LAWYERS AND

3642
02:12:05,971 --> 02:12:09,174
THE IT SECURITY ISSUES, AND

3643
02:12:09,174 --> 02:12:11,209
THEY'RE REALLY NOT FOCUSED ON A

3644
02:12:11,209 --> 02:12:11,977
FACILITATING CLINICAL RESEARCH.

3645
02:12:11,977 --> 02:12:13,945
THAT'S WHERE OUR BIGGEST PROBLEM

3646
02:12:13,945 --> 02:12:14,479
HAS BEEN.

3647
02:12:14,479 --> 02:12:15,847
THAT'S WHAT I'VE LEARNED IN THE

3648
02:12:15,847 --> 02:12:16,548
LAST 4 MONTHS.

3649
02:12:16,548 --> 02:12:18,850
SO THIS IS REALLY A ROAD, WE'VE

3650
02:12:18,850 --> 02:12:20,519
LEARNED A LOT ABOUT HOW TO

3651
02:12:20,519 --> 02:12:22,387
ENGAGE THE SITES, I THINK THAT'S

3652
02:12:22,387 --> 02:12:24,890
BASICALLY WE PUT TOGETHER

3653
02:12:24,890 --> 02:12:26,158
MATERIALS, PROBABLY TO HELP

3654
02:12:26,158 --> 02:12:27,492
INDIVIDUAL SITES AND THEIR

3655
02:12:27,492 --> 02:12:30,529
CLINICAL TRIALS OFFICES LEARN

3656
02:12:30,529 --> 02:12:32,097
WHAT WE NEED, WE NEED TO HAVE A

3657
02:12:32,097 --> 02:12:32,798
MUCH BETTER UNDERSTANDING OF

3658
02:12:32,798 --> 02:12:35,467
WHAT THE LEGAL PREPARATION NEEDS

3659
02:12:35,467 --> 02:12:37,469
TO BE TO BE ABLE TO DO THIS.

3660
02:12:37,469 --> 02:12:39,304
IT REALLY IS VERY SAFE, YOU CAN

3661
02:12:39,304 --> 02:12:40,639
GIVE A SINGLE PATIENT ACCESS,

3662
02:12:40,639 --> 02:12:42,841
ONLY FOR THE PATIENTS ON THE

3663
02:12:42,841 --> 02:12:45,677
TRIALS, SO THAT THERE'S REALLY

3664
02:12:45,677 --> 02:12:47,646
VERY LITTLE CHANCE OF DATA

3665
02:12:47,646 --> 02:12:49,614
SECURITY BEING BREECHED BUT

3666
02:12:49,614 --> 02:12:51,583
EXECUTING THE MEMORANDUM OF

3667
02:12:51,583 --> 02:12:53,518
UNDERSTANDING, SECURE THE THIRD

3668
02:12:53,518 --> 02:12:54,786
PARTY AGREEMENTS, IS TIME

3669
02:12:54,786 --> 02:12:55,854
CONSUMING BUT I THINK WILL

3670
02:12:55,854 --> 02:12:58,056
SHORTEN, AS WE'VE GOTTEN MORE

3671
02:12:58,056 --> 02:12:58,890
EXPERIENCE, AND THEN, YOU KNOW

3672
02:12:58,890 --> 02:13:01,093
WE HAVE TO AND WE'VE LEARNED

3673
02:13:01,093 --> 02:13:03,395
THAT WE NEED TO PROVIDE ONGOING

3674
02:13:03,395 --> 02:13:06,231
SUPPORT FOR THE QUESTIONS AS

3675
02:13:06,231 --> 02:13:08,433
THEY ARISE TO HELP INDIVIDUAL

3676
02:13:08,433 --> 02:13:11,269
SITES, MOVE THIS FORWARD.

3677
02:13:11,269 --> 02:13:13,305
SO LET ME JUST END BY TALKING

3678
02:13:13,305 --> 02:13:14,573
ABOUT FUTURE PLANS, SO I SAID AS

3679
02:13:14,573 --> 02:13:16,708
YOU SAW WE HAD 6 INITIAL SITES,

3680
02:13:16,708 --> 02:13:19,911
THOSE ARE SINGLE SITES, SO OUR

3681
02:13:19,911 --> 02:13:21,446
PUSH RIGHT NOW IS OF COURSE

3682
02:13:21,446 --> 02:13:22,748
EVERY 1 OF THESE MAJOR CANCER

3683
02:13:22,748 --> 02:13:26,518
CENTERS AND EVEN THE OTHER

3684
02:13:26,518 --> 02:13:28,587
SITES, THE CLINICS, HAVE

3685
02:13:28,587 --> 02:13:31,857
MULTIPLE OTHER SITES, AFFILIATE

3686
02:13:31,857 --> 02:13:33,258
SITES AND SO WE'RE TRYING TO

3687
02:13:33,258 --> 02:13:35,127
EXPAND TO AS MANY OF THE

3688
02:13:35,127 --> 02:13:36,762
AFFILIATE SITES AS POSSIBLE FOR

3689
02:13:36,762 --> 02:13:42,534
INITIAL 6, WE HAVE 3 MORE, LEAD

3690
02:13:42,534 --> 02:13:44,503
ACADEMIC NIH INSTITUTIONS BODY

3691
02:13:44,503 --> 02:13:45,937
NCORP AND NCI CENTERS THAT WE

3692
02:13:45,937 --> 02:13:47,773
HOPE TO BRING ON THIS THE NEAR

3693
02:13:47,773 --> 02:13:49,508
FUTURE, NOT READY TO SAY WHOSE

3694
02:13:49,508 --> 02:13:51,042
THOSE FOLKS ARE BUT ULTIMATELY

3695
02:13:51,042 --> 02:13:57,082
WE HOPE TO HAVE 30, 35 LEAD AND

3696
02:13:57,082 --> 02:13:57,682
AFFILIATE SITES PARTICIPATING

3697
02:13:57,682 --> 02:14:02,854
FOR THE NEXT YEAR TO 2 YEARS,

3698
02:14:02,854 --> 02:14:03,822
AND THEN REALLY UNDERSTAND THE

3699
02:14:03,822 --> 02:14:04,990
NUMBER OF TRIALS WE'RE

3700
02:14:04,990 --> 02:14:07,259
SUPPORTING TO A MUCH LARGER

3701
02:14:07,259 --> 02:14:08,226
ISSUES 20-30 TRIAL ANDS REALLY

3702
02:14:08,226 --> 02:14:09,728
UNDERSTAND WHAT ARE THE ISSUES,

3703
02:14:09,728 --> 02:14:11,930
HOW HARD IS THIS, HOW BIG OF A

3704
02:14:11,930 --> 02:14:14,099
BENEFIT IS THIS TO INDIVIDUALS,

3705
02:14:14,099 --> 02:14:17,169
AND IS THIS REALLY A SERVICE

3706
02:14:17,169 --> 02:14:18,603
THAT WILL ALLOW US, YOU KNOW

3707
02:14:18,603 --> 02:14:22,908
WHAT WE LEARN, HOW TO DO THIS,

3708
02:14:22,908 --> 02:14:24,609
HOW WE EASILY IMAGINE PROVIDING

3709
02:14:24,609 --> 02:14:25,977
ASSISTANCE OF CANCER CENTERS

3710
02:14:25,977 --> 02:14:30,248
THAT ARE ABOVE OR BEHIND THE

3711
02:14:30,248 --> 02:14:31,216
ACQUISITION, THIS CUSTOMER MIGHT

3712
02:14:31,216 --> 02:14:33,318
ALLOW US TO PROVIDE SERVICES IN

3713
02:14:33,318 --> 02:14:34,619
RURAL SITES AND MANY OTHER

3714
02:14:34,619 --> 02:14:36,922
PLACES THAT ARE NOT CURRENTLY,

3715
02:14:36,922 --> 02:14:38,490
THEY JUST DON'T HAVE THE

3716
02:14:38,490 --> 02:14:39,958
INFRASTRUCTURE BUT IF WE CAN

3717
02:14:39,958 --> 02:14:41,259
PROVIDE IT FOR THEM WHICH IS I

3718
02:14:41,259 --> 02:14:43,161
CAN TELL YOU FOR SURE, THIS CAN

3719
02:14:43,161 --> 02:14:45,797
BE DONE, IT IS BEING DONE, AND

3720
02:14:45,797 --> 02:14:47,232
REALLY IF WE HAD THE RESOURCES

3721
02:14:47,232 --> 02:14:49,201
WILL ALLOW US TO GREATLY EXPAND

3722
02:14:49,201 --> 02:14:50,368
THE NUMBER OF SITES THAT ARE

3723
02:14:50,368 --> 02:14:52,671
AVAILABLE WHERE THESE TRIALS CAN

3724
02:14:52,671 --> 02:14:53,238
BE UNDERTAKEN.

3725
02:14:53,238 --> 02:14:55,173
THE LAST THING I WANT TO SAY IS

3726
02:14:55,173 --> 02:14:56,808
IN CONVERSATION WITH THE SITES

3727
02:14:56,808 --> 02:14:57,909
THAT ARE ACTIVELY PARTICIPATING

3728
02:14:57,909 --> 02:15:00,512
IS THAT 1 OF THE THINGS ADDITION

3729
02:15:00,512 --> 02:15:02,581
TO THAT, LIST OF SERVICES IS

3730
02:15:02,581 --> 02:15:03,882
THAT THEY'RE ALSO VERY

3731
02:15:03,882 --> 02:15:06,518
INTERESTED IN WHETHER OR NOT WE

3732
02:15:06,518 --> 02:15:08,353
CAN PROVIDE ACCESS AND DATA FOR

3733
02:15:08,353 --> 02:15:09,421
LONG-TERM FOLLOW UP WHICH I HAVE

3734
02:15:09,421 --> 02:15:10,956
TO ADMIT TO YOU IS SOMETHING

3735
02:15:10,956 --> 02:15:13,225
THAT WE PAID VERY POORLY FOR,

3736
02:15:13,225 --> 02:15:15,527
RIGHT IN AND SO BUT IS

3737
02:15:15,527 --> 02:15:16,661
ABSOLUTELY NECESSARY AND SO

3738
02:15:16,661 --> 02:15:17,629
WE'RE TRYING TO CONSIDER THAT.

3739
02:15:17,629 --> 02:15:23,668
SO LET ME JUST GO ON TO

3740
02:15:23,668 --> 02:15:25,437
INTRODUCING DR. AUGUST O OCHOA

3741
02:15:25,437 --> 02:15:27,405
WHO WILL GIVE YOU HIS HANDS ON

3742
02:15:27,405 --> 02:15:29,040
EXPERIENCE WITH HIS INITIAL

3743
02:15:29,040 --> 02:15:33,078
APPROACH TO DOING THIS.

3744
02:15:33,078 --> 02:15:33,712
>> THANK YOU I DIDN'T MEAN
AND

3745
02:15:33,712 --> 02:15:35,280
THANK YOU VERY MUCH FOR HAVING

3746
02:15:35,280 --> 02:15:37,048
ME HERE TODAY WITH YOU, LET MEEE

3747
02:15:37,048 --> 02:15:47,592
IF I DID THE WRONG THING, RIGHT

3748
02:15:51,630 --> 02:15:53,765
THING IN OKAY, SO AS JIM WAS

3749
02:15:53,765 --> 02:15:57,202
TALKING ABOUT THE NASCENT IDEA

3750
02:15:57,202 --> 02:15:59,337
FOR THE VIRTUAL CLINICAL TRIALS

3751
02:15:59,337 --> 02:16:01,439
OFFICE CAME FROM WHEN WE STARTED

3752
02:16:01,439 --> 02:16:06,511
OUR SECOND PHASE OF OUR NCORP

3753
02:16:06,511 --> 02:16:09,848
INTO 2016, 2017 AND AS YOU CAN

3754
02:16:09,848 --> 02:16:11,750
SEE THE NCORP HAS MADE A

3755
02:16:11,750 --> 02:16:13,318
TREMENDOUS DIFFERENCE IN OUR

3756
02:16:13,318 --> 02:16:16,521
CORNER OF THE UNITED STATES

3757
02:16:16,521 --> 02:16:19,791
WHERE CLINICAL TRIALS WAS

3758
02:16:19,791 --> 02:16:22,661
VIRTUALLY MINIMAL PARTICIPATION

3759
02:16:22,661 --> 02:16:22,994
PRIOR TO 2010.

3760
02:16:22,994 --> 02:16:26,531
IT IS WELL IMON TO THIS AUDIENCE

3761
02:16:26,531 --> 02:16:29,367
THAT THAT THE EPICENTER OF THE

3762
02:16:29,367 --> 02:16:31,536
CANCER EPIDEMIC IS IN GREAT PART

3763
02:16:31,536 --> 02:16:34,239
IN THE GULF PART SOUTH STATES,

3764
02:16:34,239 --> 02:16:35,974
LOUISIANA, MISSISSIPPI, ALABAMA

3765
02:16:35,974 --> 02:16:37,842
AND ARKANSAS.

3766
02:16:37,842 --> 02:16:39,644
AND SO ABOUT 12-15 YEARS AGO WE

3767
02:16:39,644 --> 02:16:41,246
STARTED TRYING TO BELL A

3768
02:16:41,246 --> 02:16:43,882
COALITION OF THE BIGGEST AND

3769
02:16:43,882 --> 02:16:44,716
MOST IMPORTANT HOSPITAL SYSTEMS

3770
02:16:44,716 --> 02:16:47,352
IN THE STATE OF LOUISIANA AND

3771
02:16:47,352 --> 02:16:49,220
ALMOST ALL OF THE ACADEMIC

3772
02:16:49,220 --> 02:16:51,056
SCANSER CENTERS FORM WHAT WE NOW

3773
02:16:51,056 --> 02:16:52,490
CALL THE GULF SOUTH CLINICAL

3774
02:16:52,490 --> 02:16:53,892
TRIALS NETWORK THAT IS FUNDED

3775
02:16:53,892 --> 02:16:57,028
NOW BY THE NCORP.

3776
02:16:57,028 --> 02:16:58,964
THIS HAS MADE--RESULTED IN US

3777
02:16:58,964 --> 02:16:59,898
HAVING 49 DIFFERENT CLINICAL

3778
02:16:59,898 --> 02:17:01,299
SITES THROUGH THE REGION, MOST

3779
02:17:01,299 --> 02:17:03,268
OF THEM IN THE STATE OF

3780
02:17:03,268 --> 02:17:04,602
LOUISIANA, BUT NOW SOME IN

3781
02:17:04,602 --> 02:17:07,706
MISSISSIPPI AND NOW ACTUALLY IN

3782
02:17:07,706 --> 02:17:07,939
ALABAMA.

3783
02:17:07,939 --> 02:17:09,374
SO WE PROVIDE ACCESS TO CLINICAL

3784
02:17:09,374 --> 02:17:12,744
TRIALS THROUGH ALL OF THESE

3785
02:17:12,744 --> 02:17:13,111
SITES.

3786
02:17:13,111 --> 02:17:14,980
AND WHAT THIS RESULTED IN IS A

3787
02:17:14,980 --> 02:17:15,747
DRAMATIC IPT GREATER CREASE IN

3788
02:17:15,747 --> 02:17:18,416
THE NUMBER OF PATIENTS

3789
02:17:18,416 --> 02:17:19,117
PARTICIPATING IN CLINICAL

3790
02:17:19,117 --> 02:17:19,484
TRIALS.

3791
02:17:19,484 --> 02:17:21,953
IN 2009 IT WAS SOMEWHERE BETWEEN

3792
02:17:21,953 --> 02:17:23,254
A HUNDRED TO 150, ALTOGETHER

3793
02:17:23,254 --> 02:17:25,557
THROUGHOUT THE SAIT OF

3794
02:17:25,557 --> 02:17:26,725
LOUISIANA, TODAY WE CURRENTLY

3795
02:17:26,725 --> 02:17:29,361
ENROLL IN THE LAST 6 YEARS

3796
02:17:29,361 --> 02:17:30,895
SOMEWHERE BETWEEN 1200 TO 1500

3797
02:17:30,895 --> 02:17:31,830
PATIENTS ON CLINICAL STUDIES

3798
02:17:31,830 --> 02:17:33,431
THROUGHOUT THE WHOLE STATE.

3799
02:17:33,431 --> 02:17:34,299
AND MORE IMPORTANTLY, AS YOU CAN

3800
02:17:34,299 --> 02:17:37,769
SEE IN THAT WHYELLO LINE, THE

3801
02:17:37,769 --> 02:17:38,503
PARTICIPATION OF MINORITY

3802
02:17:38,503 --> 02:17:39,871
PATIENTS IS EVEN MORE

3803
02:17:39,871 --> 02:17:42,073
SIGNIFICANT, IT HAS DOUBLE

3804
02:17:42,073 --> 02:17:47,278
FRIDAY ABOUT 25-30% NOW, TO

3805
02:17:47,278 --> 02:17:49,414
ROUTINELY ENROLLING IN 55-60% OF

3806
02:17:49,414 --> 02:17:50,849
OUR PATIENTS REPRESENTING

3807
02:17:50,849 --> 02:17:52,317
MINORITIES MOSTLY AFRICAN

3808
02:17:52,317 --> 02:17:52,617
AMERICANS.

3809
02:17:52,617 --> 02:17:56,221
BUT NOT EVERYTHING IS HAPPY.

3810
02:17:56,221 --> 02:17:58,089
IN LOUISIANA AS WE ALWAYS THINK

3811
02:17:58,089 --> 02:18:01,826
OF ALL THE GOOD THINGS WE DO

3812
02:18:01,826 --> 02:18:04,596
BUT, BECAUSE ALTHOUGH OUR MAJOR

3813
02:18:04,596 --> 02:18:05,764
CLINICAL CENTERS ESPECIALLY IN

3814
02:18:05,764 --> 02:18:16,207
THE ACADEMEC SITES AND THE

3815
02:18:18,009 --> 02:18:21,079
CITIES IN LARGER HECK OF A TIME

3816
02:18:21,079 --> 02:18:24,349
FOR IN MEET NOTHING 2017, WE

3817
02:18:24,349 --> 02:18:32,824
ASKED THE PHYSICIANS AND WE

3818
02:18:32,824 --> 02:18:33,892
ASKED THE PROBLEM WE'RE GIVING

3819
02:18:33,892 --> 02:18:35,527
YOU EVERYTHING WE THOUGHT YOU

3820
02:18:35,527 --> 02:18:39,564
NEEDED AND THE ANSWER WAS WE

3821
02:18:39,564 --> 02:18:46,304
WOULD LOVE TO PARTICIPATE, AND

3822
02:18:46,304 --> 02:18:50,041
THEY SAID WE DON'T HAVE THE

3823
02:18:50,041 --> 02:18:52,343
CANNOT AFFORD A RESEARCH NURSE,

3824
02:18:52,343 --> 02:18:54,779
WE CANNOT AFFORD A DATA MANAGER

3825
02:18:54,779 --> 02:18:56,548
AND MUCH LESS GO THROUGH THE

3826
02:18:56,548 --> 02:18:57,615
REGULATORY PROCESSES AND THE

3827
02:18:57,615 --> 02:18:59,017
PATIENT SAID WE WOULD LOVE TO

3828
02:18:59,017 --> 02:19:00,185
PARTICIPATE BUT WE'RE NOT GOING

3829
02:19:00,185 --> 02:19:01,486
TO TRAVEL TO NEW ORLEANS WHICH

3830
02:19:01,486 --> 02:19:03,021
IS 75 OR 80-MILES AWAY OR TO ANY

3831
02:19:03,021 --> 02:19:06,925
OF THE OTHER CITIES LET US DO IT

3832
02:19:06,925 --> 02:19:07,592
CLOSER TO HOME.

3833
02:19:07,592 --> 02:19:09,561
CAN WE THOUGHT AT THAT MOMENT

3834
02:19:09,561 --> 02:19:12,297
THIS IS ESSENTIAL BECAUSE IN

3835
02:19:12,297 --> 02:19:13,965
LOUISIANA AS IN THE REST OF THE

3836
02:19:13,965 --> 02:19:14,933
COUNTRY, THE MAIORITY OF

3837
02:19:14,933 --> 02:19:16,568
PATIENTS ARE TREATED IN

3838
02:19:16,568 --> 02:19:18,336
COMMUNITY CANCER CENTERS, NOT IN

3839
02:19:18,336 --> 02:19:20,338
OUR IN, CI DESIGNATED OR IN

3840
02:19:20,338 --> 02:19:21,639
LARGE ACADEMIC TRUSTEESS, SO

3841
02:19:21,639 --> 02:19:22,841
THIS HAD TO BE ADDRESSED EMPLOY

3842
02:19:22,841 --> 02:19:28,279
SO BACK AT THAT TIME, EILEEN

3843
02:19:28,279 --> 02:19:29,447
[INDISCERNIBLE] WAS SITTING HERE

3844
02:19:29,447 --> 02:19:31,182
WITH ME AND I STARTED THINKING

3845
02:19:31,182 --> 02:19:34,285
WHAT CAN WE DO TO BRING NOT

3846
02:19:34,285 --> 02:19:35,987
TELEHEALTH WHICH TRADITIONALLY

3847
02:19:35,987 --> 02:19:38,490
BRINGS THE DOCTOR, BUT THROUGH

3848
02:19:38,490 --> 02:19:40,825
VIRTUAL MEANS BRING THE RESEARCH

3849
02:19:40,825 --> 02:19:42,227
SUPPORT TO THESE SITES AND WE

3850
02:19:42,227 --> 02:19:45,630
STARTED USING WHAT WAS THEN VERY

3851
02:19:45,630 --> 02:19:47,132
MYSTERIOUS COMMUNICATION SYSTEMS

3852
02:19:47,132 --> 02:19:49,200
THAT WE NOW KNOW HAVE CHANGED

3853
02:19:49,200 --> 02:19:50,268
COMPLETELY SINCE COVID BUT AT

3854
02:19:50,268 --> 02:19:52,036
THAT TIME WE SAID, LET'S TRY TO

3855
02:19:52,036 --> 02:19:53,605
SEE IF WE CAN SCREEN THE CLINICS

3856
02:19:53,605 --> 02:19:56,875
OF THE DOCTORS AHEAD OF TIME, SO

3857
02:19:56,875 --> 02:19:58,309
WE GOT   PERMISSION TO ACCESS

3858
02:19:58,309 --> 02:20:01,279
THE ELECTRONIC MEDICAL RECORDS,

3859
02:20:01,279 --> 02:20:03,047
OUR VIRTUAL RESEARCH NURSE

3860
02:20:03,047 --> 02:20:03,882
LOCATED IN NEW ORLEANS WOULD

3861
02:20:03,882 --> 02:20:04,582
SCREEN THE CLIN INCREASE IN

3862
02:20:04,582 --> 02:20:06,651
BODYS OF THE DOCTORS AHEAD OF

3863
02:20:06,651 --> 02:20:07,785
TIME, WOULD IEE, AUDIENCE

3864
02:20:07,785 --> 02:20:09,921
DENTIFY PATIENTS THAT ARE

3865
02:20:09,921 --> 02:20:11,623
POTENTIALLY ELIGIBLE FOR

3866
02:20:11,623 --> 02:20:12,457
CLINICAL TRIALS, WOULD DISCUSS

3867
02:20:12,457 --> 02:20:15,059
THOSE PEASHTS WITH THE DOCTOR,

3868
02:20:15,059 --> 02:20:20,131
THE WEEK BEFORE AND THEN THE

3869
02:20:20,131 --> 02:20:22,133
DOCTOR WOULD INTRODUCE THE IDEA

3870
02:20:22,133 --> 02:20:23,168
OF PARTICIPATING A CLINICAL

3871
02:20:23,168 --> 02:20:24,169
TRIAL TO THE PEASHT WHEN THE

3872
02:20:24,169 --> 02:20:25,570
PATIENT ARRIVED IN THE CLINIC,

3873
02:20:25,570 --> 02:20:26,871
IF THE PATIENT SAID YES, THEN

3874
02:20:26,871 --> 02:20:30,708
THEY WOULD CLICK THE COMPUTER

3875
02:20:30,708 --> 02:20:31,776
ON, THE VIRTUAL RESEARCH NURSE

3876
02:20:31,776 --> 02:20:33,645
WOULD COME ON AND IN SOME CASES

3877
02:20:33,645 --> 02:20:35,747
WE ACTUALLY HAD A LITTLE LAPTOP

3878
02:20:35,747 --> 02:20:37,382
IN NOSE PLACES THAT THE VIRTUAL

3879
02:20:37,382 --> 02:20:38,583
RESEARCH NURSE WAS THERE ALL THE

3880
02:20:38,583 --> 02:20:40,218
TIME AND SO THEN THE VIRTUAL

3881
02:20:40,218 --> 02:20:43,188
RESEARCH NURSE WOULD DO THE

3882
02:20:43,188 --> 02:20:45,123
CONSENTING, COMPLETE ALL THE

3883
02:20:45,123 --> 02:20:47,091
PAPERWORK NEEDED FOR ENROLLMENT

3884
02:20:47,091 --> 02:20:48,626
OF THE PATIENTS, SET THE

3885
02:20:48,626 --> 02:20:49,894
CALENDERS FOR ALL THE ACTIVITY

3886
02:20:49,894 --> 02:20:54,632
ANDS THEN CONTINUE THE FOLLOW

3887
02:20:54,632 --> 02:20:54,799
UP.

3888
02:20:54,799 --> 02:20:57,302
WE TESTED THIS INITIALLY IN 2

3889
02:20:57,302 --> 02:20:59,003
VERY DIFFERENT SITES, 1 WAS A

3890
02:20:59,003 --> 02:21:00,171
SMALL RURAL HOSPITAL WITH A

3891
02:21:00,171 --> 02:21:01,906
HUNDRED AND SOMETHING ANALYTIC

3892
02:21:01,906 --> 02:21:03,441
CASES WITH A PART-TIME

3893
02:21:03,441 --> 02:21:04,742
ONCOLOGIST WHO SAID THEY WANTED

3894
02:21:04,742 --> 02:21:06,311
TO TEST THIS WITH 1 TRIAL.

3895
02:21:06,311 --> 02:21:09,480
THE OTHER 1 WAS A SMALL ACADEMIC

3896
02:21:09,480 --> 02:21:12,050
GU PRACTICE THAT WAS AT A

3897
02:21:12,050 --> 02:21:12,850
SUBURBAN HOSPITAL, NOT

3898
02:21:12,850 --> 02:21:13,785
ASSOCIATED DIRECTLY WITH THE

3899
02:21:13,785 --> 02:21:15,153
CANCER TRUSTEES.

3900
02:21:15,153 --> 02:21:16,955
AND WHAT WE FOUND OUT WAS 2

3901
02:21:16,955 --> 02:21:18,456
THINGS, NUMBER 1 WE BEING SCREEN

3902
02:21:18,456 --> 02:21:19,857
THE PATIENTS AHEAD OF TIME SO AS

3903
02:21:19,857 --> 02:21:22,227
YOU CAN SEE IN BOTH SITES WE

3904
02:21:22,227 --> 02:21:24,429
SCREENED ACTIVELY BUT THE ONLY

3905
02:21:24,429 --> 02:21:25,797
ENROLLMENTS HAPPENED IN THE SITE

3906
02:21:25,797 --> 02:21:29,367
WHERE NUMBER 1 THERE WAS A

3907
02:21:29,367 --> 02:21:30,501
CRITICAL NUMBER OF CLINICAL

3908
02:21:30,501 --> 02:21:33,104
TRIALS OPEN AND NUMBER 2 WHERE

3909
02:21:33,104 --> 02:21:34,138
THERE WERE FULL-TIME PHYSICIANS

3910
02:21:34,138 --> 02:21:35,707
THAT WERE REALLY COMMITTED TO

3911
02:21:35,707 --> 02:21:37,976
THIS PROCESS, SO AT THAT TIME, 2

3912
02:21:37,976 --> 02:21:38,676
THINGS HAPPENED, NUMBER 1 WE

3913
02:21:38,676 --> 02:21:43,047
CAME TO TALK TO THE NCI, AND WE

3914
02:21:43,047 --> 02:21:44,782
TALKED TO WHARTA Mc KASP A R

3915
02:21:44,782 --> 02:21:46,985
KILL STEPHENS AT THAT TIMES ARE

3916
02:21:46,985 --> 02:21:48,219
AND WAS ENTHUSIASTIC BUT SAID

3917
02:21:48,219 --> 02:21:50,021
SHOW ME CAN YOU DO THIS IN MORE

3918
02:21:50,021 --> 02:21:52,156
THAN A COUPLE PLACES THAN YOU'VE

3919
02:21:52,156 --> 02:21:52,390
DONE.

3920
02:21:52,390 --> 02:21:55,059
AND THE SECOND 1 WE TALKED TO

3921
02:21:55,059 --> 02:21:56,461
JIM DOROSHOW, AND SAID THE SAME

3922
02:21:56,461 --> 02:21:58,296
THING, THE NEXT THING THAT

3923
02:21:58,296 --> 02:22:00,565
HAPPENED WAS COVID AND WHEN

3924
02:22:00,565 --> 02:22:02,433
COVID HIT, 2 THINGS WERE VERY

3925
02:22:02,433 --> 02:22:03,735
IMPORTANT, NUMBER 1 ALL OF THESE

3926
02:22:03,735 --> 02:22:05,103
RULINNATED ANTIGENSS AND

3927
02:22:05,103 --> 02:22:07,872
REGULATIONS WE HAD ABOUT VIRTUAL

3928
02:22:07,872 --> 02:22:09,407
COMMUNICATIONS WERE NOW AT THE

3929
02:22:09,407 --> 02:22:10,675
DOOR, EVERYBODY STARTED

3930
02:22:10,675 --> 02:22:11,943
COMMUNICATING, EVERYBODY STARTED

3931
02:22:11,943 --> 02:22:13,811
SHARING INFORMATION, AND SO WE

3932
02:22:13,811 --> 02:22:14,379
DID THE SAME.

3933
02:22:14,379 --> 02:22:18,883
SO WE CONTINUED WITH OUR

3934
02:22:18,883 --> 02:22:20,184
ONCOLOGY, OUR GU ONCOLOGY GROUP.

3935
02:22:20,184 --> 02:22:23,821
WE OPENED UP ANOTHER RURAL SITE,

3936
02:22:23,821 --> 02:22:25,790
AT GULF PORT MEMORIAL HOSPITAL

3937
02:22:25,790 --> 02:22:27,859
IN GULF PORT MISSISSIPPI AND

3938
02:22:27,859 --> 02:22:29,227
RECENTLY OPENED A SECOND

3939
02:22:29,227 --> 02:22:30,928
SUBURBAN HOSPITAL SITE AND AS

3940
02:22:30,928 --> 02:22:33,398
YOU CAN SEE HERE OF ALL THE

3941
02:22:33,398 --> 02:22:35,566
PATIENTS, WE WERE ABLE CLEARLY

3942
02:22:35,566 --> 02:22:37,235
TO PRESCREEN THE PATIENTS,

3943
02:22:37,235 --> 02:22:40,805
IDENTIFY THOSE AND IN THE SITES

3944
02:22:40,805 --> 02:22:42,840
WHERE IT BECAME A ROUTINE TO

3945
02:22:42,840 --> 02:22:45,043
HAVE PATIENTS ENROLL IN CLINICAL

3946
02:22:45,043 --> 02:22:46,811
TRIALS, LIKE THE GU SITE, THE

3947
02:22:46,811 --> 02:22:48,146
FIRST 1 YOU SEE UP THERE,

3948
02:22:48,146 --> 02:22:50,014
SCWEAT% OF OUR PATIENTS WENT ON

3949
02:22:50,014 --> 02:22:50,682
CLINICAL TRIALS, THE INTERESTING

3950
02:22:50,682 --> 02:22:53,751
PART IS THAT THE OTHER SUBURBAN

3951
02:22:53,751 --> 02:22:55,453
HOSPITAL IS ALSO RAPIDLY RAMPING

3952
02:22:55,453 --> 02:22:59,090
UP AND THE RURAL HOSPITAL HAS

3953
02:22:59,090 --> 02:23:00,291
BEEN SLOWLY GETTING THERE AND

3954
02:23:00,291 --> 02:23:01,893
I'LL TELL YOU A LITTLE BIT MORE

3955
02:23:01,893 --> 02:23:04,862
ABOUT WHY WE THINK THAT IT IS

3956
02:23:04,862 --> 02:23:06,064
NOT AS RAPID AS WHAT WE WOULD

3957
02:23:06,064 --> 02:23:08,700
LIKE BUT THE OTHER THING THAT'S

3958
02:23:08,700 --> 02:23:10,201
IMPORTANT IS THAT IT REALLY ARK

3959
02:23:10,201 --> 02:23:11,269
TRACTED THE ATTENTION OF THE

3960
02:23:11,269 --> 02:23:12,904
PHYSICIANS AT THOSE SITES WHO

3961
02:23:12,904 --> 02:23:14,105
RAPIDLY INCREASED THE NUMBER OF

3962
02:23:14,105 --> 02:23:17,175
CLINICAL TRIALS THAT THEY WANTED

3963
02:23:17,175 --> 02:23:17,975
TO OPEN.

3964
02:23:17,975 --> 02:23:21,746
SO IN SUMMARY OVER THE SEVERAL

3965
02:23:21,746 --> 02:23:24,916
YEARS THAT WE TESTED THIS, WE

3966
02:23:24,916 --> 02:23:26,851
PREKREENED ABOUT 2300 PATIENTS,

3967
02:23:26,851 --> 02:23:29,253
WE ENROLLED ABOUT 140, THE VRN

3968
02:23:29,253 --> 02:23:30,688
CAN KREEN AND ENROLL PATIENTS,

3969
02:23:30,688 --> 02:23:32,990
IT HAS ESTABLISHED INTEREST ON

3970
02:23:32,990 --> 02:23:34,058
THE CLINICIANS FOR PARTICIPATING

3971
02:23:34,058 --> 02:23:36,694
THIS AND HAS HELPED US BUILD

3972
02:23:36,694 --> 02:23:40,264
TRUST WITH THESE RURAL SITES AND

3973
02:23:40,264 --> 02:23:41,532
THESE COMMUNITY CLINICS.

3974
02:23:41,532 --> 02:23:42,367
THEY ALSO ATTRACTED THE

3975
02:23:42,367 --> 02:23:45,069
ATTENTION OF THE FEDERAL

3976
02:23:45,069 --> 02:23:46,337
GOVERNMENT, DR. BIDEN CAME TO

3977
02:23:46,337 --> 02:23:48,106
VISIT US AND SEE HOW THIS

3978
02:23:48,106 --> 02:23:48,339
WORKED.

3979
02:23:48,339 --> 02:23:49,407
WE ACTUALLY, YOU CAN SEE THE

3980
02:23:49,407 --> 02:23:52,343
SCREEN OF THE TV WE'RE CONNECK

3981
02:23:52,343 --> 02:23:53,678
WIDE THE GULF PORT SITE AND IF

3982
02:23:53,678 --> 02:23:55,513
YOU LOOK AT THE RATE SITE HERE,

3983
02:23:55,513 --> 02:23:58,416
CAN YOU SEE DR. DOROSHOW, HIDING

3984
02:23:58,416 --> 02:24:02,720
THERE BEHIND SOMEBODY ELSE.

3985
02:24:02,720 --> 02:24:04,255
SO LESSONED LEARNED FROM WHAT WE

3986
02:24:04,255 --> 02:24:05,890
CALL THE VIRTUAL RESEARCH NURSE,

3987
02:24:05,890 --> 02:24:08,393
IT CAN SUPPORT CLINICAL TRIALS,

3988
02:24:08,393 --> 02:24:11,496
BUT, AS DR. DOROSHOW SAID, EACH

3989
02:24:11,496 --> 02:24:12,997
SITE IS DIFFERENT, YOU HAVE TO

3990
02:24:12,997 --> 02:24:17,935
WORK VERY CLOSELY WITH EACH SITE

3991
02:24:17,935 --> 02:24:20,438
OUR VIRTUAL RESEARCH NURSE NEEDS

3992
02:24:20,438 --> 02:24:25,209
WEEKLY WITH OUR PHYSICIANS AT

3993
02:24:25,209 --> 02:24:27,011
THE DIFFERENT SITES AND WE MEET

3994
02:24:27,011 --> 02:24:29,514
WITH THEM IN PERSON QUARTERLY TO

3995
02:24:29,514 --> 02:24:30,915
REVIEW CLINICAL TRIALS,

3996
02:24:30,915 --> 02:24:31,849
ACCRUALS, WHICH TRIALS NEED TO

3997
02:24:31,849 --> 02:24:33,117
BE CLOSE, WHICH TRIALS NEED TO

3998
02:24:33,117 --> 02:24:33,618
BE OPEN.

3999
02:24:33,618 --> 02:24:36,287
WE ALSO NEED TO GET DATA SO WE

4000
02:24:36,287 --> 02:24:37,422
CAN REAMLY REFINE THIS PROCESS,

4001
02:24:37,422 --> 02:24:41,359
SO WE'RE IN THE PROCESS OF

4002
02:24:41,359 --> 02:24:42,660
COLLECTING DATA THROUGH DATA

4003
02:24:42,660 --> 02:24:44,295
PLAN, RESEARCH LOGS ISSUES

4004
02:24:44,295 --> 02:24:45,596
PATIENT ENGAGEMENT SURVEYS AND

4005
02:24:45,596 --> 02:24:46,864
STRUCTURED INTERVIEWS THAT ARE

4006
02:24:46,864 --> 02:24:48,266
BEING LED BY DENISE

4007
02:24:48,266 --> 02:24:51,269
[INDISCERNIBLE], 1 OF OUR PUBLIC

4008
02:24:51,269 --> 02:24:51,969
HEALTH STATISTICIANS.

4009
02:24:51,969 --> 02:24:53,271
BUT I THINK 1 OF THE LESSONS

4010
02:24:53,271 --> 02:24:56,441
THAT I LEARNED VERY QUICKLY WAS

4011
02:24:56,441 --> 02:24:58,209
THAT THE MOST IMPORTANT HELP WE

4012
02:24:58,209 --> 02:25:00,711
RECEIVED WAS FROM BEING PART OF

4013
02:25:00,711 --> 02:25:01,546
THE NCORP.

4014
02:25:01,546 --> 02:25:03,314
ALL OUR SITES ARE PART OF THE

4015
02:25:03,314 --> 02:25:06,818
NCORP AND SO GETTING USER

4016
02:25:06,818 --> 02:25:07,752
AGREEMENTS AND BUSINESS

4017
02:25:07,752 --> 02:25:10,421
ASSOCIATE AGREEMENTS SO THAT WE

4018
02:25:10,421 --> 02:25:11,689
CAN ACTUALLY ACCESS ELECTRONIC

4019
02:25:11,689 --> 02:25:13,424
MEDICAL RECORS WAS TREMENDOUSLY

4020
02:25:13,424 --> 02:25:17,328
MUCH EASIER THAN IF WE WERE

4021
02:25:17,328 --> 02:25:19,297
WORKING WITH UNAFFILIATED SITES.

4022
02:25:19,297 --> 02:25:21,265
OUR NEXT STEP IS TO CONTINUE THE

4023
02:25:21,265 --> 02:25:24,302
COLLECTION OF DATA, THE SECOND

4024
02:25:24,302 --> 02:25:26,871
PART WAS AS I PROMISED

4025
02:25:26,871 --> 02:25:28,306
DR. DOROSHOW BACK THEN THAT WE

4026
02:25:28,306 --> 02:25:32,443
WOULD WRITE SOPs SO THAT

4027
02:25:32,443 --> 02:25:33,845
ANYBODY COULD TAKE THIS

4028
02:25:33,845 --> 02:25:34,579
SOPUNISHINGs AND IMPLEMENT

4029
02:25:34,579 --> 02:25:36,214
THEM AT THEIR SITES ACCORDING TO

4030
02:25:36,214 --> 02:25:39,383
THEIR NEEDS BUT I THINK MORE

4031
02:25:39,383 --> 02:25:47,492
IMPORTANTLY IS WHAT JIM IS

4032
02:25:47,492 --> 02:25:58,002
ALOUDING TO, TRYING TO PROVIDE

4033
02:26:37,174 --> 02:26:38,643
MUCHERS--DENISE DENNIS WAS 1 OF

4034
02:26:38,643 --> 02:26:40,678
OUR OTHER COLLABORATORS AT THESE

4035
02:26:40,678 --> 02:26:45,149
COMMUNITY HOSPITALS THAT HAVE

4036
02:26:45,149 --> 02:26:46,284
PARTICIPATED WITH US FINALLY

4037
02:26:46,284 --> 02:26:48,252
THIS WAS FUNDED BY PILOT GRANT

4038
02:26:48,252 --> 02:26:51,422
FROM THE NCORP PROGRAM AND FROM

4039
02:26:51,422 --> 02:26:53,057
THE ALL CORP LAND FOUNDATION CHO

4040
02:26:53,057 --> 02:26:54,325
IS OUR LOCAL SUPPORTER SO THANK

4041
02:26:54,325 --> 02:27:04,135
YOU AND WE WILL TAKE SOME

4042
02:27:04,135 --> 02:27:04,402
QUESTIONS.

4043
02:27:04,402 --> 02:27:06,671
>> WE HAVE A LOT OF HANDS.

4044
02:27:06,671 --> 02:27:06,938
TART HERE.

4045
02:27:06,938 --> 02:27:07,305
>> THANK YOU.

4046
02:27:07,305 --> 02:27:09,307
THAT WAS A TBRAIT PRESENTATION

4047
02:27:09,307 --> 02:27:11,442
AND I WOULD LOVE THE PRACTICAL

4048
02:27:11,442 --> 02:27:14,378
APPLICATION OF, YOU KNOW YOUR

4049
02:27:14,378 --> 02:27:16,480
VISION TO HEAR IT, I WAS

4050
02:27:16,480 --> 02:27:18,349
WONDERING 2 THINGS, 1, HOW ARE

4051
02:27:18,349 --> 02:27:21,052
YOU SELECTING THE SITES TO

4052
02:27:21,052 --> 02:27:22,453
PARTICIPATE, I IMAGINE THERE

4053
02:27:22,453 --> 02:27:23,854
WOULD BE INTEREST AND YOU'RE

4054
02:27:23,854 --> 02:27:26,324
LOOKING FOR, YOU KNOW KIND OF

4055
02:27:26,324 --> 02:27:28,259
REPRESENTATION, SO, JUST CURIOUS

4056
02:27:28,259 --> 02:27:30,227
HOW COULD A SITE GET INVOLVED OR

4057
02:27:30,227 --> 02:27:33,431
ARE YOU AT THIS POINT ARE YOU

4058
02:27:33,431 --> 02:27:33,864
HAND [INDISCERNIBLE]

4059
02:27:33,864 --> 02:27:35,800
>> SO BASICALLY THIS START
WIDE

4060
02:27:35,800 --> 02:27:38,102
A BIG SURVEY OF ALL THE CANCER

4061
02:27:38,102 --> 02:27:39,036
CENTERS AND CORE SITE ANDS THEY

4062
02:27:39,036 --> 02:27:40,705
HAD TO FILL OUT AND PROVIETD US

4063
02:27:40,705 --> 02:27:43,007
DATA WITH, I MEAN, IT'S

4064
02:27:43,007 --> 02:27:44,175
BASICALLY RESILIENCE PORT CARD.

4065
02:27:44,175 --> 02:27:47,311
HOW FAR ARE YOU BEHIND IN YOUR

4066
02:27:47,311 --> 02:27:48,279
DATA MANAGE AM.

4067
02:27:48,279 --> 02:27:50,281
WHAT IS YOUR PERCENT OF RURAL OR

4068
02:27:50,281 --> 02:27:51,248
PATIENT POPULATION, HOW MANY

4069
02:27:51,248 --> 02:27:52,950
PROTOCOLS DO YOU HAVE OPEN, ARE

4070
02:27:52,950 --> 02:27:56,053
YOU--DO YOU THINK THAT YOUR IT

4071
02:27:56,053 --> 02:27:57,622
SYSTEMS AND SECURITY ANALYSTS

4072
02:27:57,622 --> 02:27:59,090
WILL ACTUALLY ARK LOW US TO

4073
02:27:59,090 --> 02:28:02,093
PARTICIPATE AND WE PLAYED A HUGE

4074
02:28:02,093 --> 02:28:04,061
GRID AND PRIORITIZED BASED ON

4075
02:28:04,061 --> 02:28:05,129
EXACTLY THE NEED AND IN

4076
02:28:05,129 --> 02:28:06,864
PARTICULAR, THE NEED IN THE

4077
02:28:06,864 --> 02:28:09,100
CONTEXT OF TRYING TO FOCUS ON

4078
02:28:09,100 --> 02:28:11,836
RURAL AND UNDERSERVED

4079
02:28:11,836 --> 02:28:13,571
POPULATIONS NAND YOUR 3 NEW

4080
02:28:13,571 --> 02:28:24,048
CERNER SITES ARE ALONG THAT.

4081
02:28:24,248 --> 02:28:24,982
>> EXACTLY.

4082
02:28:24,982 --> 02:28:25,916
>> DR. OCHOA, TALKING
ABOUT

4083
02:28:25,916 --> 02:28:27,218
UNDERRESOURCING OF RURAL

4084
02:28:27,218 --> 02:28:28,519
COMMUNITIES, ET CETERA, I'M

4085
02:28:28,519 --> 02:28:31,255
WONDERING IF YOU CONSIDERED

4086
02:28:31,255 --> 02:28:32,657
DEVELOPING COMMUNITY HEALTHCARE

4087
02:28:32,657 --> 02:28:34,191
WORKFORCE THAT SUPPORTS, YOU

4088
02:28:34,191 --> 02:28:35,459
KNOW ADDRESSES CULTURAL LANGUAGE

4089
02:28:35,459 --> 02:28:36,827
ANDET ESTROGEN, THOSE NEEDS BUT

4090
02:28:36,827 --> 02:28:38,696
CAN KEEP THE LINKAGE BETWEEN THE

4091
02:28:38,696 --> 02:28:42,099
COMMUNITY HOSPITAL, THE VIRTUAL,

4092
02:28:42,099 --> 02:28:46,270
ET CETERA, ET CETERA AND AT THE

4093
02:28:46,270 --> 02:28:49,407
SAME TIME PUT UNDER--I THINK

4094
02:28:49,407 --> 02:28:50,675
UNDER EMPLOYEES TO WORK AND GIVE

4095
02:28:50,675 --> 02:28:52,510
THEM SOME WORK IN THOSE

4096
02:28:52,510 --> 02:28:54,478
COMMUNITIES BECAUSE THEY CAN

4097
02:28:54,478 --> 02:28:56,147
BECOME THE GLUE AND THE BRIDGE

4098
02:28:56,147 --> 02:28:59,984
TO ALL OF THIS WORK.

4099
02:28:59,984 --> 02:29:01,352
>> AND THANK YOU FOR THAT

4100
02:29:01,352 --> 02:29:02,420
QUESTION BECAUSE CLEARLY IT'S

4101
02:29:02,420 --> 02:29:03,020
VERY TIMELY.

4102
02:29:03,020 --> 02:29:04,522
WE HAVE JUST STARTED

4103
02:29:04,522 --> 02:29:05,690
CONVERSATIONS WITH OUR COMMUNITY

4104
02:29:05,690 --> 02:29:09,660
OUTREACH PROGRAMS THAT ACTUALLY

4105
02:29:09,660 --> 02:29:11,595
RUN THE KREENING, THE EARLY

4106
02:29:11,595 --> 02:29:13,364
DETECTION PROGRAMS FOR BREAST,

4107
02:29:13,364 --> 02:29:14,432
CERVICAL AND COLORECTAL AND

4108
02:29:14,432 --> 02:29:15,399
SEVERAL OTHER PARTS THROUGHOUT

4109
02:29:15,399 --> 02:29:18,202
THE STATE WITH THE IDEA OF

4110
02:29:18,202 --> 02:29:19,837
FINDING WAYS TO LINK WHAT WE DO

4111
02:29:19,837 --> 02:29:20,671
WITH OUR VIRTUAL PROGRAM AND

4112
02:29:20,671 --> 02:29:24,508
WHAT THEY'RE DOING SO THAT WE

4113
02:29:24,508 --> 02:29:26,744
CAN TURN OUR COMMUNITY EDUCATORS

4114
02:29:26,744 --> 02:29:32,516
INTO FACILITATOR OF THIS

4115
02:29:32,516 --> 02:29:33,184
PROCESS.

4116
02:29:33,184 --> 02:29:33,484
>> NEALY?

4117
02:29:33,484 --> 02:29:35,286
>> THANK YOU SO MUCH FOR

4118
02:29:35,286 --> 02:29:37,488
TACKLING THIS BIG CHALLENGE IN

4119
02:29:37,488 --> 02:29:38,789
SUCH CREATIVE WAYS.

4120
02:29:38,789 --> 02:29:39,457
A COUPLE COMMENTS.

4121
02:29:39,457 --> 02:29:42,226
ONE IS THAT DO HAVE YOU ANY

4122
02:29:42,226 --> 02:29:44,528
COMPONENTS OF EDUCATION FOR THE

4123
02:29:44,528 --> 02:29:46,630
PATIENTS BECAUSE WE FOUND IN A

4124
02:29:46,630 --> 02:29:48,332
SURVEY IN THE MOUNTAIN WEST THAT

4125
02:29:48,332 --> 02:29:50,768
88% OF THE PEOPLE WHO LIVE

4126
02:29:50,768 --> 02:29:54,071
THERE, WHO SURVEY DID NOT KNOW

4127
02:29:54,071 --> 02:29:55,673
ABOUT CLINICAL TRIALS AND COMING

4128
02:29:55,673 --> 02:29:57,742
IN WITHOUT KNOWING ABOUT IT,

4129
02:29:57,742 --> 02:30:00,511
MAKES THAT CONVERSATION WITH THE

4130
02:30:00,511 --> 02:30:01,545
CLINICIAN LESS PRODUCTIVE AND

4131
02:30:01,545 --> 02:30:04,815
THE SECOND PART IS A CALL UPON

4132
02:30:04,815 --> 02:30:06,217
COLLABORATING WITH YOUR NEW

4133
02:30:06,217 --> 02:30:07,184
SENIOR DIRECTOR FOR DATA SCIENCE

4134
02:30:07,184 --> 02:30:09,920
BECAUSE WE WILL NEVER BE ABLE TO

4135
02:30:09,920 --> 02:30:12,223
FUND FOR EVERY CENTER A VIRTUAL

4136
02:30:12,223 --> 02:30:14,992
NURSE BUT WHAT ABOUT USING LARGE

4137
02:30:14,992 --> 02:30:16,160
LANGUAGE MODELS, TRYING TO HELP

4138
02:30:16,160 --> 02:30:22,032
TO DO SOME OF THAT PREPARATION,

4139
02:30:22,032 --> 02:30:23,634
EDUCATION BEFORE PATIENTS COME

4140
02:30:23,634 --> 02:30:23,801
IN.

4141
02:30:23,801 --> 02:30:26,504
>> SO I THINK THE LATTER
IS

4142
02:30:26,504 --> 02:30:28,806
GOING TO BE VERY IMPORTANT BUT

4143
02:30:28,806 --> 02:30:32,877
NOT SO SIMPLE, RIGHT?

4144
02:30:32,877 --> 02:30:35,212
BECAUSE IT TIES TOGETHER WITH

4145
02:30:35,212 --> 02:30:39,183
THE NEEDS TO--LET'S WRUOF THE BE

4146
02:30:39,183 --> 02:30:39,416
HONEST.

4147
02:30:39,416 --> 02:30:42,386
WE WOULD ALL LOVE TO HAVE MOST

4148
02:30:42,386 --> 02:30:45,890
OF THIS INFORMATION AT LEAST THE

4149
02:30:45,890 --> 02:30:48,392
DATA MANAGEMENT ISSUE AND THE

4150
02:30:48,392 --> 02:30:50,127
ELEMENTS WE COLLECT BE DONE IN

4151
02:30:50,127 --> 02:30:51,095
AN AUTOMATED FASHION, RIGHT?

4152
02:30:51,095 --> 02:30:52,830
AND THAT WOULD BE--THAT WOULD BE

4153
02:30:52,830 --> 02:30:54,732
OUR GOAL AND IT'S NOT SO SIMPLE

4154
02:30:54,732 --> 02:31:00,070
AND IT'S NOT GOING TO HAPPEN

4155
02:31:00,070 --> 02:31:01,138
TOMORROW, RIGHT?

4156
02:31:01,138 --> 02:31:02,673
BUT THAT'S WHERE WHERE I THINK

4157
02:31:02,673 --> 02:31:04,275
THE KIND OF LARGE LANGUAGE

4158
02:31:04,275 --> 02:31:05,676
ACTIVITIES MIGHT BE MOST HELPFUL

4159
02:31:05,676 --> 02:31:07,411
EMPLOY WE STILL ARE--THERE ARE

4160
02:31:07,411 --> 02:31:09,647
MANY OTHER THINGS ON THAT LIST,

4161
02:31:09,647 --> 02:31:13,350
ON THAT PORTFOLIO OF SERVICES

4162
02:31:13,350 --> 02:31:15,352
THAT ARE NOT SO--WOULD JUST BE

4163
02:31:15,352 --> 02:31:18,489
TAKEN UP BY AN AI MODEL.

4164
02:31:18,489 --> 02:31:22,259
IN ESSENCE WE WANT A LARGE SCALE

4165
02:31:22,259 --> 02:31:24,428
HELP DESK AND THIS IS REALLY

4166
02:31:24,428 --> 02:31:26,263
CRITICAL FOR SMALL SITES TO BE

4167
02:31:26,263 --> 02:31:28,032
ABLE TO HAVE ESSENTIALLY AT

4168
02:31:28,032 --> 02:31:29,667
LEAST 8 HOURS A DAY, THERE'S

4169
02:31:29,667 --> 02:31:30,968
SOMEONE TO CALL WHO'S

4170
02:31:30,968 --> 02:31:32,236
KNOWLEDGEABLE, WE DON'T

4171
02:31:32,236 --> 02:31:33,871
UNDERSTAND, WHAT DOES THIS

4172
02:31:33,871 --> 02:31:34,805
PROTOCOL REALLY MEAN, WHAT DO

4173
02:31:34,805 --> 02:31:36,473
YOU HAVE TO COLLECT, HOW DO

4174
02:31:36,473 --> 02:31:39,109
YOU--CAN YOU HELP US WITH OUR

4175
02:31:39,109 --> 02:31:41,111
LOCAL CONSENT ISSUES, OR OTHER

4176
02:31:41,111 --> 02:31:42,513
ISSUES, AND SO WITH THAT, YOU

4177
02:31:42,513 --> 02:31:43,814
REALLY DO NEED, I THINK AT LEAST

4178
02:31:43,814 --> 02:31:46,250
FOR THE TIME BEING, YOU NEED

4179
02:31:46,250 --> 02:31:47,751
PEOPLE, RIGHT, TO BE ABLE TO DO

4180
02:31:47,751 --> 02:31:50,554
THAT AND YOU ANSWER IT, YOUR

4181
02:31:50,554 --> 02:31:51,822
FIRST QUESTION WAS.

4182
02:31:51,822 --> 02:31:54,758
>> EDUCATION. 

4183
02:31:54,758 --> 02:31:55,726
>> EDUCATION.

4184
02:31:55,726 --> 02:31:56,093
>> EDUCATION.

4185
02:31:56,093 --> 02:31:58,028
>> SO BASICALLY 1 OF THE
MAJOR

4186
02:31:58,028 --> 02:31:59,096
COMPONENTS OF THIS ACTIVITY IS

4187
02:31:59,096 --> 02:32:01,498
TO DEVELOP AN EDUCATIONAL

4188
02:32:01,498 --> 02:32:03,801
MATERIALS SO ON THAT KIND OF--I

4189
02:32:03,801 --> 02:32:05,236
WENT THROUGH IT VERY FAST, THE

4190
02:32:05,236 --> 02:32:06,871
WINDY ROAD OF WHERE WE ARE,

4191
02:32:06,871 --> 02:32:08,639
THERE'S A WHOLE PIECE TO EDUCATE

4192
02:32:08,639 --> 02:32:10,407
THE SITE, BOTH FOR PATIENTS AND

4193
02:32:10,407 --> 02:32:12,710
FOR THE NURSES AND THE PROVIDERS

4194
02:32:12,710 --> 02:32:17,248
TO REALLY, WHAT IS THAT ALL

4195
02:32:17,248 --> 02:32:18,315
ABOUT, YOU KNOW, BECAUSE SOMEONE

4196
02:32:18,315 --> 02:32:19,483
MIGHT BE CONCERNED THEY SHOW UP

4197
02:32:19,483 --> 02:32:21,719
ON A SCREEN FOR SOMEONE WHO'S

4198
02:32:21,719 --> 02:32:22,920
OVERHERE, WHO KNOWS WHERE,

4199
02:32:22,920 --> 02:32:24,521
LOOKING AT THEIR DATA AND

4200
02:32:24,521 --> 02:32:26,590
TALKING TO THEM ABOUT THIS WHOLE

4201
02:32:26,590 --> 02:32:28,492
PROCESS, SO YES, THERE'S AN

4202
02:32:28,492 --> 02:32:30,094
EDUCATIONAL PIECE THAT'S BUILT

4203
02:32:30,094 --> 02:32:30,327
IN.

4204
02:32:30,327 --> 02:32:33,464
>> SO WE HAVE HOWARD AND
RAY AND

4205
02:32:33,464 --> 02:32:36,634
ABDOMEN RIA, CHRIS, WELL THE'S

4206
02:32:36,634 --> 02:32:37,501
TART WITH HOWARD.

4207
02:32:37,501 --> 02:32:38,269
>> NTHANK YOU.

4208
02:32:38,269 --> 02:32:40,938
I WAS REALLY IMPRESSED WITH JIM,

4209
02:32:40,938 --> 02:32:45,409
YOU'RE TALKING THIS ON AND DOING

4210
02:32:45,409 --> 02:32:47,144
THIS, SO ACCRUAL IS A GREAT END

4211
02:32:47,144 --> 02:32:49,013
POINT, AND I MIGHT HAVE MISSED

4212
02:32:49,013 --> 02:32:52,116
IT BUT DID YOU TALK ABOUT

4213
02:32:52,116 --> 02:32:53,550
ANYTHING FOR ADHERENCE AND

4214
02:32:53,550 --> 02:32:55,819
INTENTION AND COMPLETERS, I WAS

4215
02:32:55,819 --> 02:32:57,855
INTRIGUED BY AN ASH PRESENTATION

4216
02:32:57,855 --> 02:33:00,791
FROM GRADY HOSPITAL IN ATLANTA

4217
02:33:00,791 --> 02:33:04,795
THAT ABOUT A YEAR AND A HALF AGO

4218
02:33:04,795 --> 02:33:08,799
THAT PARTNERED WITH CVS PHARMACY

4219
02:33:08,799 --> 02:33:10,067
ARE LOOKING AT MYELOMA

4220
02:33:10,067 --> 02:33:13,938
PRESCRINGZS AND WHAT THEY SHOWED

4221
02:33:13,938 --> 02:33:14,939
THAT THE OUTCOMES, HEALTH

4222
02:33:14,939 --> 02:33:17,741
OUTCOMES OF THE PATIENTS WERE

4223
02:33:17,741 --> 02:33:18,943
REALLY LINKED TO THE, YOU KNOW

4224
02:33:18,943 --> 02:33:22,246
THE DATA THAT THEY HAD ABOUT

4225
02:33:22,246 --> 02:33:24,214
RETENTION THAT CVS HELPED THEM,

4226
02:33:24,214 --> 02:33:26,550
SOPHISTICATED IT WAS NOT EPIC,

4227
02:33:26,550 --> 02:33:29,386
IT WAS CVS, IT WAS THE FIRST

4228
02:33:29,386 --> 02:33:31,889
TIME I SAW CVS AT A NATIONAL

4229
02:33:31,889 --> 02:33:34,658
CONFERENCE, ABOUT YOU IT SHOWS

4230
02:33:34,658 --> 02:33:36,427
THE PHARMACY GROUPS MIGHT BE

4231
02:33:36,427 --> 02:33:37,328
INTERESTED IN FURTHER PARTNERING

4232
02:33:37,328 --> 02:33:40,030
ABOUT THIS KIND OF WORK NI THINK

4233
02:33:40,030 --> 02:33:42,199
THAT'S PART OF THAT I WILL TAKE

4234
02:33:42,199 --> 02:33:44,969
OIT'S OBVIOUS THAT IF WE'RE

4235
02:33:44,969 --> 02:33:47,271
ACTUALLY DOING THE DATA MANAGE

4236
02:33:47,271 --> 02:33:48,305
AM THEN THE AUDITING GOES HAND

4237
02:33:48,305 --> 02:33:49,373
IN HAND.

4238
02:33:49,373 --> 02:33:53,277
SO WE'LL HAVE ADHERENCE DATA

4239
02:33:53,277 --> 02:33:54,445
BECAUSE WE WILL--WE ARE ACTUALLY

4240
02:33:54,445 --> 02:33:56,113
HELPING WITH THE MOVEMENT OF THE

4241
02:33:56,113 --> 02:33:59,049
INFORMATION FROM THE EHR

4242
02:33:59,049 --> 02:34:01,685
INTORAPHY AND SO IT'S ALMOST AS

4243
02:34:01,685 --> 02:34:08,792
IF WE'RE DOING A REALTIME

4244
02:34:08,792 --> 02:34:11,028
AUDITING FUNCTION BECAUSE WE'RE

4245
02:34:11,028 --> 02:34:21,572
PROVIDING THAT SERVICE HANDS ON.

4246
02:34:24,074 --> 02:34:26,176
>> YEAH, JUST A GREAT

4247
02:34:26,176 --> 02:34:26,744
PRESENTATION, LOVE IT.

4248
02:34:26,744 --> 02:34:31,348
TWO OBSERVATIONS AND MAYBE A

4249
02:34:31,348 --> 02:34:31,949
QUESTION.

4250
02:34:31,949 --> 02:34:35,486
THE FIRST SUBDIVISION IS EXACTLY

4251
02:34:35,486 --> 02:34:35,719
RIGHT.

4252
02:34:35,719 --> 02:34:38,355
THE VAST MAJORITY OF CANCER CARE

4253
02:34:38,355 --> 02:34:40,190
DELIVERY IS IN HIEWNT HEALTHCARE

4254
02:34:40,190 --> 02:34:43,727
SYSTEMS AND IF WE WANT TO YOU

4255
02:34:43,727 --> 02:34:48,165
KNOW CONVERT THEM FROM DESERTS

4256
02:34:48,165 --> 02:34:51,368
TO TROPICAL LIMATES WE HAVE TO

4257
02:34:51,368 --> 02:34:52,436
ENGAME THEM DIRECTLY AND DO

4258
02:34:52,436 --> 02:34:59,476
EXACTLY WHAT YOU DID WHICH IS

4259
02:34:59,476 --> 02:35:01,545
LEARN FROM THEM WHAT IS YOUR

4260
02:35:01,545 --> 02:35:02,579
EXPERIENCE, DON'T

4261
02:35:02,579 --> 02:35:03,680
[INDISCERNIBLE] IN YOUR IVORY

4262
02:35:03,680 --> 02:35:04,982
TOWER, GO TO THE PLACE WHERE THE

4263
02:35:04,982 --> 02:35:06,917
WORK IS BEING DONE, TRY TO

4264
02:35:06,917 --> 02:35:09,253
FIGURE OUT HOW CAN MAKE THIS FIT

4265
02:35:09,253 --> 02:35:10,854
THIS IN THIS IS IMPORTANT

4266
02:35:10,854 --> 02:35:11,088
ENOUGH.

4267
02:35:11,088 --> 02:35:13,090
THE OTHER OBSERVATION IS EXACTLY

4268
02:35:13,090 --> 02:35:15,292
WHAT YOU POINTED OUT, THE MAIP

4269
02:35:15,292 --> 02:35:16,293
BARRIERS ARE NOT PATIENT LEVEL,

4270
02:35:16,293 --> 02:35:18,028
WE ALL KNOW THIS, IT'S

4271
02:35:18,028 --> 02:35:19,329
INSTITUTIONAL AND PROVIEDMAN US,

4272
02:35:19,329 --> 02:35:19,663
RIGHT?

4273
02:35:19,663 --> 02:35:21,265
AND WE'RE GOING TO SOLVE THIS

4274
02:35:21,265 --> 02:35:22,900
PROBLEM, WE'RE GOING TO HAVE TO

4275
02:35:22,900 --> 02:35:24,568
ENGAGE THE INNS TUITIONS AND THE

4276
02:35:24,568 --> 02:35:27,905
PROVIDERS, IN THE PLACES WHERE

4277
02:35:27,905 --> 02:35:29,807
THE PATIENTS GO.

4278
02:35:29,807 --> 02:35:31,708
THE QUESTION I HAVE IS THERE'S

4279
02:35:31,708 --> 02:35:33,544
THIS ECHO MODEL THAT HAS BEEN

4280
02:35:33,544 --> 02:35:37,314
VERY SUCCESSFUL IN MANY OTHER

4281
02:35:37,314 --> 02:35:47,758
REALMS, THIS SEEMS LIKE A

4282
02:35:48,092 --> 02:35:49,560
WONDERFUL OPPORTUNITY TO USE THE

4283
02:35:49,560 --> 02:35:52,262
ECHO MODEL TO DO SOMETHING

4284
02:35:52,262 --> 02:35:52,629
BENEFICIAL.

4285
02:35:52,629 --> 02:35:54,064
ANY IDEAS ABOUT HOW 1 COULD USE

4286
02:35:54,064 --> 02:35:59,636
THE ECHO MODEL IN THIS ENDEAVOR?

4287
02:35:59,636 --> 02:36:00,337
>> SO GOOD QUESTION.

4288
02:36:00,337 --> 02:36:01,872
WE LOOKED AT THE ECHO MODEL

4289
02:36:01,872 --> 02:36:03,373
EARLY ON WITH THE IDEA THAT WE

4290
02:36:03,373 --> 02:36:06,677
BEING USE A SIMILAR APPROACH BUT

4291
02:36:06,677 --> 02:36:09,179
I THINK THAT YOU MADE A VERY

4292
02:36:09,179 --> 02:36:10,114
IMPORTANT POINT IN YOUR FIRST

4293
02:36:10,114 --> 02:36:12,216
STATEMENT AND THAT IS THAT EACH

4294
02:36:12,216 --> 02:36:13,817
SITE, YOU HAVE TO GAIN THEIR

4295
02:36:13,817 --> 02:36:18,655
TRUST, IT'S NOT THAT YOU BRING

4296
02:36:18,655 --> 02:36:20,591
THEIR, THE BIG MODEL, THE BIG

4297
02:36:20,591 --> 02:36:21,725
OVERWHELMING MODEL THAT'S GOING

4298
02:36:21,725 --> 02:36:23,026
TO WORK HERE, YOU HAVE TO WORK

4299
02:36:23,026 --> 02:36:24,328
WITH THEM, TALK WITH THEM, GIVE

4300
02:36:24,328 --> 02:36:26,964
THEM A SENSE OF CONTROL AND

4301
02:36:26,964 --> 02:36:28,665
INPUT, THEY ARE GOING TO TELL US

4302
02:36:28,665 --> 02:36:31,335
WHAT IS IMPORTANT AND WHY

4303
02:36:31,335 --> 02:36:34,138
THEY'RE FALLING BEHIND.

4304
02:36:34,138 --> 02:36:35,072
THE ACADEMIC PARTNER COMOONT

4305
02:36:35,072 --> 02:36:36,907
COME IN A PATERNALISTIC APPROACH

4306
02:36:36,907 --> 02:36:38,942
AND SO WITH THE ECHO MODEL,

4307
02:36:38,942 --> 02:36:41,011
ALTHOUGH WE HAD SEVERAL MEETINGS

4308
02:36:41,011 --> 02:36:42,112
AND APPROACHES AND THOUGHT OF

4309
02:36:42,112 --> 02:36:44,715
HOW TO IMPLEMENT IT, WE WERE

4310
02:36:44,715 --> 02:36:47,718
UNABLE TO GET TRACTION ON THAT.

4311
02:36:47,718 --> 02:36:49,887
THIS INSTEAD BECAUSE WE WERE

4312
02:36:49,887 --> 02:36:51,622
BRINGING THEIR NURSES, WE WERE

4313
02:36:51,622 --> 02:36:53,123
BRINGING THEIR PHYSICIANS, WE

4314
02:36:53,123 --> 02:36:54,658
WERE GOING THERE AND

4315
02:36:54,658 --> 02:36:55,325
PARTICIPATING AND DISCUSSING

4316
02:36:55,325 --> 02:36:57,561
WITH THEM, THAT CREATED THE

4317
02:36:57,561 --> 02:36:59,296
EMPATHY AND THE DISCUSSION

4318
02:36:59,296 --> 02:37:01,598
PROCESS THAT ALLOWED THEM TO

4319
02:37:01,598 --> 02:37:02,900
ACTUALLY HELP US TELL THEM, TELL

4320
02:37:02,900 --> 02:37:05,969
US WHAT WE NEEDED TO BUILD AND

4321
02:37:05,969 --> 02:37:07,704
SO THAT'S HOW WE'VE SLOWLY BUILD

4322
02:37:07,704 --> 02:37:09,173
THEM AND THAT'S WHY IT'S TAKEN A

4323
02:37:09,173 --> 02:37:13,076
FEW YEARS TO GET WHERE WE ARE.

4324
02:37:13,076 --> 02:37:13,911
>> THANK YOU, ANDREA.

4325
02:37:13,911 --> 02:37:19,349
NTHAIRNG YOU AGAIN, THIS IS

4326
02:37:19,349 --> 02:37:19,783
OUTSTANDING WORK.

4327
02:37:19,783 --> 02:37:21,285
AS FAR AS THE TRUST YOU JUST

4328
02:37:21,285 --> 02:37:23,053
STARTED TO TALK ABOUT AND

4329
02:37:23,053 --> 02:37:25,222
TRUFFING IN THE COMMUNITY, WHEN

4330
02:37:25,222 --> 02:37:27,324
WE ENROLL PATIENTS IN CLINICAL

4331
02:37:27,324 --> 02:37:28,959
TRIES WE ARE LIKELY TO INN ROLL

4332
02:37:28,959 --> 02:37:30,894
IF THE PERSON PROVIEDMANNING THE

4333
02:37:30,894 --> 02:37:32,129
INFORMATION LOOKS LIKE THEM OR

4334
02:37:32,129 --> 02:37:33,497
IS OF A SIMILAR ETHNIC GROUP AND

4335
02:37:33,497 --> 02:37:36,233
I DIDN'T SEE THE EXACT

4336
02:37:36,233 --> 02:37:37,968
PERCENTAGES OF ENROLLEE IN BLACK

4337
02:37:37,968 --> 02:37:39,136
VERSUS WHITE PATIENTS BUT IS

4338
02:37:39,136 --> 02:37:40,404
THERE AN OPPORTUNITY WITH YOUR

4339
02:37:40,404 --> 02:37:42,739
VIRTUAL WERE NURSES TO INCREASE

4340
02:37:42,739 --> 02:37:48,812
THE NUMBER OF ETHNICALLY DIVERSE

4341
02:37:48,812 --> 02:37:50,547
RESEARCH NURSES IN ORDER TO

4342
02:37:50,547 --> 02:37:51,748
INCREASE THEIR WORK ON THE

4343
02:37:51,748 --> 02:37:52,082
TRIALS.

4344
02:37:52,082 --> 02:37:54,751
I SUSPECT THERE'S ONLY A FEW,

4345
02:37:54,751 --> 02:37:57,321
BUT THERE MAY BE ONLY 1 OR 2 BUT

4346
02:37:57,321 --> 02:37:59,489
IT SEEMS TO ME IF WE WOULD USE

4347
02:37:59,489 --> 02:38:03,126
THIS OPPORTUNITY TO INCREASE THE

4348
02:38:03,126 --> 02:38:06,129
NUMBER OF DIVERSE PRN THEN

4349
02:38:06,129 --> 02:38:07,297
ENROLLMENT ON THESE CLINICAL

4350
02:38:07,297 --> 02:38:08,232
TRIALS WOULD INCREASE.

4351
02:38:08,232 --> 02:38:13,070
>> VERY IMPORTANT POINT. 

4352
02:38:13,070 --> 02:38:16,173
SO 2 THINGS, WE HAVE WORK WITH

4353
02:38:16,173 --> 02:38:18,008
OUR SITES RATHER THAN GO TO 2

4354
02:38:18,008 --> 02:38:19,409
SITES AND WORK FOR THEM IS

4355
02:38:19,409 --> 02:38:20,544
BECAUSE THEY HAVE CREATED THAT

4356
02:38:20,544 --> 02:38:21,645
EMPATHY IN THE COMMUNITY.

4357
02:38:21,645 --> 02:38:22,980
THEY RELATE TO THE COMMUNITY,

4358
02:38:22,980 --> 02:38:24,081
THEY REPRESENT IN THE COMMUNITY,

4359
02:38:24,081 --> 02:38:25,082
THEY LIVE IN THE COMMUNITY AND

4360
02:38:25,082 --> 02:38:29,553
SO WE'RE NOT BRINGING THE

4361
02:38:29,553 --> 02:38:30,354
DOCTORS OR NURSES.

4362
02:38:30,354 --> 02:38:32,589
THE NURSES ARE ONLY PROVIDING A

4363
02:38:32,589 --> 02:38:36,927
SUPPORT STRATEGIES AND THEY'RE

4364
02:38:36,927 --> 02:38:38,428
PROVYING THE VR NS AND YOU

4365
02:38:38,428 --> 02:38:39,730
SHOULD EVERYBODY SHOULD LEARN TO

4366
02:38:39,730 --> 02:38:41,298
BE A VRN IN OUR TEAM AND THAT'S

4367
02:38:41,298 --> 02:38:42,199
WHAT THE PLAN IS.

4368
02:38:42,199 --> 02:38:45,702
NOW WE'RE TARTING WITH A FEW

4369
02:38:45,702 --> 02:38:47,804
THAT WE TRAIN SO THEY CAN THEN

4370
02:38:47,804 --> 02:38:48,972
TRAIN THE OTHERS NTHANKS IN THE

4371
02:38:48,972 --> 02:38:50,807
INTEREST OF TIME WE WILL DO 2

4372
02:38:50,807 --> 02:38:53,143
MORE BUT PLEASE BE SUCCINCT AND

4373
02:38:53,143 --> 02:38:54,778
FOCUS ON YOUR QUESTIONS.

4374
02:38:54,778 --> 02:39:04,221
LET'S GO DR. LOPEZ AND NEWMAN.

4375
02:39:04,221 --> 02:39:04,988
>> THANK YOU.

4376
02:39:04,988 --> 02:39:07,190
THANK FOR AN EXCELLENT

4377
02:39:07,190 --> 02:39:08,959
PRESENTATION AND EXCELLENT WORK,

4378
02:39:08,959 --> 02:39:11,828
WHAT I WONDERED IS YOU MENTIONED

4379
02:39:11,828 --> 02:39:14,698
SOPs EMPLOY SO DISSEMINATION

4380
02:39:14,698 --> 02:39:15,465
IS CRITICAL.

4381
02:39:15,465 --> 02:39:17,668
AND WE'VE ALL SEEN THAT DESPITE

4382
02:39:17,668 --> 02:39:19,636
THE TREMENDOUS PROGRESS THAT WE

4383
02:39:19,636 --> 02:39:21,405
MADE WITH TELEMEDICINE, IT'S ALL

4384
02:39:21,405 --> 02:39:23,907
GOING BACKWARDS, AND ARE YOU

4385
02:39:23,907 --> 02:39:34,418
FINDING SIMILAR RESISTANCE TO

4386
02:39:34,651 --> 02:39:36,320
USING THESE VIRTUAL SYSTEMS FOR

4387
02:39:36,320 --> 02:39:37,621
CLINICAL TRIALS NI DON'T THINK

4388
02:39:37,621 --> 02:39:39,456
IT'S AS MUCH RESISTANCE, IT'S

4389
02:39:39,456 --> 02:39:40,891
ABOUT EICATION AND EDUCATION

4390
02:39:40,891 --> 02:39:42,059
WITH THE PATIENTS BUT ALSO

4391
02:39:42,059 --> 02:39:43,560
EDUCATION WITH THE COMMUNITY

4392
02:39:43,560 --> 02:39:44,861
PHYSICIANS BECAUSE THE GREAT

4393
02:39:44,861 --> 02:39:46,830
MAIORITY OF OUR ONCOLOGISTS ARE

4394
02:39:46,830 --> 02:39:52,169
NOT TRAINED IN RESEARCH

4395
02:39:52,169 --> 02:39:53,904
INTENSIVE CENTERS SO REMEMBER 10

4396
02:39:53,904 --> 02:39:55,105
YEARS AGO, CLINICAL TRIALS WERE

4397
02:39:55,105 --> 02:39:56,406
SORT OF THE LAST DITCH EFFORT

4398
02:39:56,406 --> 02:40:00,677
FOR A PATIENT, THAT WAS THE

4399
02:40:00,677 --> 02:40:01,611
COMMON, TODAY IT'S NOT.

4400
02:40:01,611 --> 02:40:03,380
TODAY SHOULD BE PART OF THE

4401
02:40:03,380 --> 02:40:04,681
PLANNING OF A REGULAR TREATMENT

4402
02:40:04,681 --> 02:40:06,249
ON A PATIENT.

4403
02:40:06,249 --> 02:40:07,884
AND SO, IF THE DOCTORS IN THE

4404
02:40:07,884 --> 02:40:10,287
COMMUNITY HAVE BEEN TRAINED MORE

4405
02:40:10,287 --> 02:40:11,621
THAN 10, 20 YEARS AGO, THEY

4406
02:40:11,621 --> 02:40:13,223
DON'T HAVE THAT EXPERTISE, THEY

4407
02:40:13,223 --> 02:40:14,091
DON'T HAVE THAT EXPERIENCE, SO

4408
02:40:14,091 --> 02:40:17,160
WHEN WE HAVE TO WORK WITH THEM

4409
02:40:17,160 --> 02:40:19,463
AND THAT'S HOW WE WORK FOR

4410
02:40:19,463 --> 02:40:20,764
EXAMPLE, WITH THE GULF PORT

4411
02:40:20,764 --> 02:40:20,997
TEAM.

4412
02:40:20,997 --> 02:40:23,667
THEY HAVE LEARNED AND NOW ARE

4413
02:40:23,667 --> 02:40:24,968
RAPIDLY OPENING UP NEW TRIALS SO

4414
02:40:24,968 --> 02:40:27,170
IT'S A PROCESS OF TRAINING AND

4415
02:40:27,170 --> 02:40:27,437
EDUCATION.

4416
02:40:27,437 --> 02:40:29,072
>> SO LISA AND I WILL
ALLOW THE

4417
02:40:29,072 --> 02:40:31,174
1 FINAL QUESTION FROM

4418
02:40:31,174 --> 02:40:32,042
DR. [INDISCERNIBLE].

4419
02:40:32,042 --> 02:40:34,945
HE HAD HIS HAND UP, BUT I WILL

4420
02:40:34,945 --> 02:40:38,248
ALLOW LISA PLEASE BE SUSSIRNGHT.

4421
02:40:38,248 --> 02:40:38,949
>> IFY QUESTION WAS
ADVERSITY SO

4422
02:40:38,949 --> 02:40:40,884
THANK IF YOU ARE THAT, JUST 1

4423
02:40:40,884 --> 02:40:42,386
LOGISTICS QUESTION, YOU KNOW

4424
02:40:42,386 --> 02:40:44,121
WE'RE ALSO CONSTRAINED IN TERMS

4425
02:40:44,121 --> 02:40:46,923
OF PACE AND TIME IN CLINIC WITH

4426
02:40:46,923 --> 02:40:48,325
REGARD TO INTRODUCING THE

4427
02:40:48,325 --> 02:40:50,293
PATIENTS FROM VIRTUAL NURSE

4428
02:40:50,293 --> 02:40:52,095
MODEL IS WONDERFUL, HOW MUCH

4429
02:40:52,095 --> 02:40:53,530
FLEXIBILITY DO THOSE VIRTUAL

4430
02:40:53,530 --> 02:40:56,400
NURSES HAVE IN TERMS OF THOSE

4431
02:40:56,400 --> 02:40:59,002
INTERACS OCCURRING AT THE PATES

4432
02:40:59,002 --> 02:41:03,306
WITH THE CELL PHONE?

4433
02:41:03,306 --> 02:41:04,374
>> WHATEVER WORKS.

4434
02:41:04,374 --> 02:41:11,181
THE MODEL IS WHATEVER WORKS.

4435
02:41:11,181 --> 02:41:11,882
>> SO, PART THAT ALLOWS US
TO

4436
02:41:11,882 --> 02:41:13,283
CONTINUE THE FOLLOW UP THE

4437
02:41:13,283 --> 02:41:14,551
PATIENTS IS THAT THEY CAN

4438
02:41:14,551 --> 02:41:15,619
COMMUNICATE WITH A RESEARCH

4439
02:41:15,619 --> 02:41:15,886
NURSE.

4440
02:41:15,886 --> 02:41:17,387
NOW THE INTAKE IS IN THE

4441
02:41:17,387 --> 02:41:19,256
DOCTOR'S OFFICE ISSUES THE

4442
02:41:19,256 --> 02:41:20,724
INITIAL PROCESS, BUT THE FOLLOW

4443
02:41:20,724 --> 02:41:24,261
UP CAN BE DONE IN OUR VIRTUAL

4444
02:41:24,261 --> 02:41:26,530
RESEARCH NURSE FOLLOWS THOSE

4445
02:41:26,530 --> 02:41:28,231
PATIENTS.

4446
02:41:28,231 --> 02:41:28,732
YES OF COURSE.

4447
02:41:28,732 --> 02:41:32,068
>> FINAL QUESTION.

4448
02:41:32,068 --> 02:41:35,405
IN, YES, IMETTING CARE CLOSE TO

4449
02:41:35,405 --> 02:41:36,239
HOME, IMPROVES PATIENT

4450
02:41:36,239 --> 02:41:37,274
SATISFACTION, SO IT'S ASHES

4451
02:41:37,274 --> 02:41:41,611
MAZING THAT OUT OF THE 2400

4452
02:41:41,611 --> 02:41:43,447
PATIENTS, 1400 WERE FROM THE

4453
02:41:43,447 --> 02:41:44,614
ORIGINAL LOCATION, SO THAT

4454
02:41:44,614 --> 02:41:53,356
ALREADY IS A SUCCESS.

4455
02:41:53,356 --> 02:41:54,291
>> THANKS, WONDERFUL

4456
02:41:54,291 --> 02:41:54,858
PRESENTATION AND DISCUSSION.

4457
02:41:54,858 --> 02:42:03,500
THANK YOU.

4458
02:42:03,500 --> 02:42:05,235
SO THE BOARD WILL NOW CONSIDER

4459
02:42:05,235 --> 02:42:06,403
ONGOING AND NEW BUSINESS, FIRST

4460
02:42:06,403 --> 02:42:07,737
WE WILL CONSIDER THE REPORTS

4461
02:42:07,737 --> 02:42:09,673
FROM THE 3 SUBMITEES THAT MET

4462
02:42:09,673 --> 02:42:12,175
LAST EVENING.

4463
02:42:12,175 --> 02:42:13,743
THE SUBMITEE CHAIRS WILL GIVE

4464
02:42:13,743 --> 02:42:15,245
THE REPORTS, THE FIRST

4465
02:42:15,245 --> 02:42:18,849
SUBCOMMITTEE REPORT WILL BE

4466
02:42:18,849 --> 02:42:21,952
GIIVE BY DR. NEIL AZAD, CHAIR

4467
02:42:21,952 --> 02:42:25,155
FOR THE SUBCOMMITTEE ON CLINICAL

4468
02:42:25,155 --> 02:42:27,090
INVESTIGATORS, MILO.

4469
02:42:27,090 --> 02:42:28,024
>> GOOD MORNING EVERYBODY
IT WAS

4470
02:42:28,024 --> 02:42:29,993
A REAL PLEASURE TO BE ABLE TO

4471
02:42:29,993 --> 02:42:32,162
CHAIR THE SUBCOMMITTEE MEETING

4472
02:42:32,162 --> 02:42:33,897
YESTERDAY EVENING WHICH IS A

4473
02:42:33,897 --> 02:42:35,165
PERFECT SEGUE FROM WHAT WE'VE

4474
02:42:35,165 --> 02:42:36,233
BEEN TALKING ABOUT THIS MORNING

4475
02:42:36,233 --> 02:42:38,201
WHICH IS ABOUT HOW WE CAN DO

4476
02:42:38,201 --> 02:42:39,402
PRAGMATIC TRIALS THAT CAN ALLOW

4477
02:42:39,402 --> 02:42:41,271
US TO INCREASE THE KIND OF

4478
02:42:41,271 --> 02:42:42,339
ENROLLMENT THAT WE GET AND THAT

4479
02:42:42,339 --> 02:42:44,307
REALLY ARK LOW US TO REPRESENT

4480
02:42:44,307 --> 02:42:45,141
THE TRUE POPULATION IN THE

4481
02:42:45,141 --> 02:42:51,014
UNITED STATES AND SO, WE

4482
02:42:51,014 --> 02:42:52,249
DEDICATED THIS MING LAST NIGHT

4483
02:42:52,249 --> 02:42:53,583
TO THE LUNG CANCER PRAGMATIC

4484
02:42:53,583 --> 02:42:54,718
TRIAL WHICH IS DIFFICULT TO

4485
02:42:54,718 --> 02:42:58,955
DRIEB IN ANY OTHER TERMS AS AN

4486
02:42:58,955 --> 02:43:00,357
UNQUALIFIED SUCCESS FOR THE

4487
02:43:00,357 --> 02:43:01,424
CLINICAL INVESTIGATIONS GROUPS

4488
02:43:01,424 --> 02:43:05,195
WITHIN THE NCI, AND SO,

4489
02:43:05,195 --> 02:43:08,365
DR. MARGARET MOONY WHO IS THE

4490
02:43:08,365 --> 02:43:09,566
ASSOCIATE DIRECTOR OF CTEP AND

4491
02:43:09,566 --> 02:43:11,067
THE DIVISION OF CANCER TREATMENT

4492
02:43:11,067 --> 02:43:13,937
AND DIAGNOSIS, CAME AND

4493
02:43:13,937 --> 02:43:15,372
PRESENTED AND AN UPDATE AN

4494
02:43:15,372 --> 02:43:16,540
INTERIM ANALYSIS OF THE SUCCESS

4495
02:43:16,540 --> 02:43:18,642
SO FAR OF THE LUNG CANCER

4496
02:43:18,642 --> 02:43:22,712
PRAGMATIC TRIAL AND SO, YOU KNOW

4497
02:43:22,712 --> 02:43:24,281
AS PRELIMINARY DATA FOR WHY THIS

4498
02:43:24,281 --> 02:43:26,816
TRIAL ACTUALLY MOVED FORWARD,

4499
02:43:26,816 --> 02:43:27,751
DR. MOONY PRESENTED THE RESULTS

4500
02:43:27,751 --> 02:43:30,353
OF THE SURVEY THAT WAS

4501
02:43:30,353 --> 02:43:31,588
ADMINISTERED TO THE NATIONAL

4502
02:43:31,588 --> 02:43:32,889
CLIN KACCTICAL TRIAL IT IS WORK

4503
02:43:32,889 --> 02:43:34,758
SOCIETY ABOUT 2IERS AGO IN 2022,

4504
02:43:34,758 --> 02:43:36,459
AND WHAT THAT SURVEY HAD SHOWN

4505
02:43:36,459 --> 02:43:38,261
WHICH WE TALKED ABOUT IN A

4506
02:43:38,261 --> 02:43:39,296
PREVIOUS SUBCOMMITTEE MEETING IS

4507
02:43:39,296 --> 02:43:40,096
THAT THERE WAS GENERAL

4508
02:43:40,096 --> 02:43:42,399
SATISFACTION WITH MANY CAN

4509
02:43:42,399 --> 02:43:44,267
COMPONENTS OF THE NCTN AND

4510
02:43:44,267 --> 02:43:45,435
IMPROVEMENTS HAD BEEN MADE OVER

4511
02:43:45,435 --> 02:43:46,503
THE LAST FRIEW YEARS BUT THERE

4512
02:43:46,503 --> 02:43:48,939
CONTINUE TO BE HIGH LEVELS OF

4513
02:43:48,939 --> 02:43:50,941
DISSEFGZ FOR A COUPLE KEY AREAS

4514
02:43:50,941 --> 02:43:52,976
AND THAT INCLUDED THE ENROLLMENT

4515
02:43:52,976 --> 02:43:54,010
OF DIVERSE POPULATIONS WHICH WAS

4516
02:43:54,010 --> 02:43:56,780
STILL FELT TO BE A WEAKNESS, AND

4517
02:43:56,780 --> 02:43:58,281
THE EFFICIENT ACTIVATION AND

4518
02:43:58,281 --> 02:43:59,950
COMPLETION OF CLINICAL TROOLS SO

4519
02:43:59,950 --> 02:44:03,053
TIMELINES, AND THEN OF COURSE,

4520
02:44:03,053 --> 02:44:04,321
THERE FTION SIGNIFICANT

4521
02:44:04,321 --> 02:44:05,722
CHALLENGES AROUND FUNDING AND

4522
02:44:05,722 --> 02:44:07,457
THE AMOUNT OF PER PATIENT

4523
02:44:07,457 --> 02:44:10,026
FUNDING THAT THE NCTN GETS FOR

4524
02:44:10,026 --> 02:44:12,095
EACH ENROLLMENT SO WHAT COULD WE

4525
02:44:12,095 --> 02:44:14,464
DO TO INCREASE THEENTIOUS

4526
02:44:14,464 --> 02:44:16,466
FICIENCY OF THOSE FUNDS.

4527
02:44:16,466 --> 02:44:18,335
SO THE LUNG CANCER PRAGMATIC

4528
02:44:18,335 --> 02:44:19,869
TRIAL WAS DESEENED TO REALLY RYE

4529
02:44:19,869 --> 02:44:22,339
TO FOCUS ON SOME OF THESE KEY

4530
02:44:22,339 --> 02:44:24,641
BARRIERS, IT WAS DESIGNED IN

4531
02:44:24,641 --> 02:44:25,442
COLLABORATION WITH INDUSTRY,

4532
02:44:25,442 --> 02:44:27,877
WHICH IS AN IMPORTANT COMPONENT

4533
02:44:27,877 --> 02:44:29,879
OF THIS, SO, BOTH ELI ILLUMINATE

4534
02:44:29,879 --> 02:44:31,147
EXPE MARK WERE INVOLVED

4535
02:44:31,147 --> 02:44:32,682
IMPORTANTLY IN THIS DESIGN, AND

4536
02:44:32,682 --> 02:44:34,884
IT WAS DESIGNED TO ANSWER

4537
02:44:34,884 --> 02:44:35,819
QUESTIONS THAT--A QUESTION THAT

4538
02:44:35,819 --> 02:44:36,920
WAS IMPORTANT TO THE RESEARCH

4539
02:44:36,920 --> 02:44:39,122
COMMUNITY AND TO THE CLINICAL

4540
02:44:39,122 --> 02:44:40,957
TREATMENT COMMUNITY AND SO, IT

4541
02:44:40,957 --> 02:44:42,926
REALLY WAS FOCUSED ON AN AREA

4542
02:44:42,926 --> 02:44:44,561
THAT INDUSTRY MIGHT NOT TAKE ON

4543
02:44:44,561 --> 02:44:46,396
THEMSELVES, BUT IS STILL AN

4544
02:44:46,396 --> 02:44:48,898
IMPORTANT QUESTION WHEN IT COMES

4545
02:44:48,898 --> 02:44:50,767
TO TREATING PEASHTS AND SO THIS

4546
02:44:50,767 --> 02:44:53,703
TRIAL LOOKED AT PATIENTS THAT

4547
02:44:53,703 --> 02:44:55,405
HAD ALREADY HAD FIRST LINE

4548
02:44:55,405 --> 02:44:56,239
THERAPY FOR METASTATIC DISEASE

4549
02:44:56,239 --> 02:44:57,273
AND LUNG CANCER AND PATIENTS

4550
02:44:57,273 --> 02:44:58,108
WERE RANDOMIZED TRIAL OPEN

4551
02:44:58,108 --> 02:44:59,509
MEETINGIZED IN A VERY PRAGMATIC

4552
02:44:59,509 --> 02:45:01,878
WAY IN A STANDARD OF CARE IN A

4553
02:45:01,878 --> 02:45:07,884
SECOND LINE, FOR PROVIDER CHOICE

4554
02:45:07,884 --> 02:45:10,754
ACROSS GUIDE LINES ACROSS THE

4555
02:45:10,754 --> 02:45:12,255
EXPERIMENTAL GROUP OF

4556
02:45:12,255 --> 02:45:12,956
[INDISCERNIBLE] AND

4557
02:45:12,956 --> 02:45:13,990
[INDISCERNIBLE] PARTICULAR

4558
02:45:13,990 --> 02:45:15,725
COMPANIES INVOLVED AND BASED ON

4559
02:45:15,725 --> 02:45:19,295
STRONG PRELIMINARY DATA FROM A

4560
02:45:19,295 --> 02:45:21,131
RANDOMIZED PHASE 2 STUDY THAT

4561
02:45:21,131 --> 02:45:22,666
SHOWED A TREND TOWARDS

4562
02:45:22,666 --> 02:45:24,067
IMPROVEMENT IN SURVIVAL BUT WHAT

4563
02:45:24,067 --> 02:45:25,935
WAS KEY WAS REALLY A SIMPLIFIED

4564
02:45:25,935 --> 02:45:28,071
DESIGN OF THE TRIAL AND A

4565
02:45:28,071 --> 02:45:29,339
SIMPLIFIED CONSENTS PROCESS AND

4566
02:45:29,339 --> 02:45:30,540
SO EARLIER TODAY, WE TALKED

4567
02:45:30,540 --> 02:45:33,343
ABOUT THE CONSENT FORM FOR THAT

4568
02:45:33,343 --> 02:45:37,047
TRIAL SO THAT WAS ONLY 11 PAGES,

4569
02:45:37,047 --> 02:45:38,648
SO DR. REDFIELD REMEANEDDED ME

4570
02:45:38,648 --> 02:45:40,183
IT WAS ONLY 7 PAGES IF YOU TOOK

4571
02:45:40,183 --> 02:45:42,185
OUT THE 4 PAGES REQUIRED OF IT

4572
02:45:42,185 --> 02:45:44,654
SO IT WAS A SHORTENED CONSENT,

4573
02:45:44,654 --> 02:45:50,226
IT HAD REDUCED DATA COLLECTION

4574
02:45:50,226 --> 02:45:50,960
EVEN IMPANELING AT ANY TIME HAVE

4575
02:45:50,960 --> 02:45:53,430
TO BE PUT INTO THE DATABASES,

4576
02:45:53,430 --> 02:45:55,398
SINCE OVERALL SURVIVAL WAS THE

4577
02:45:55,398 --> 02:45:55,765
END POINT.

4578
02:45:55,765 --> 02:45:58,802
THE RISK PROFILE OF THIS--THESE

4579
02:45:58,802 --> 02:46:00,437
DRUGS WERE WELL KNOWN AND SO THE

4580
02:46:00,437 --> 02:46:03,406
IF, DA ALSO ALLOWED FOR REALLY

4581
02:46:03,406 --> 02:46:05,775
VERY LIMITED TOXICITY COLLECTION

4582
02:46:05,775 --> 02:46:07,544
AROUND SEVERE TOXICITY SO IT

4583
02:46:07,544 --> 02:46:09,412
MADE IT EASIER FOR SITES TO BE

4584
02:46:09,412 --> 02:46:10,346
ABLE TO ENROLL.

4585
02:46:10,346 --> 02:46:12,282
THE TIMELINE FROM WHEN THE

4586
02:46:12,282 --> 02:46:13,483
PROPOSAL WAS FITTER SENT TO THE

4587
02:46:13,483 --> 02:46:15,685
STEERING COMMITTEE TO ACTIVATION

4588
02:46:15,685 --> 02:46:17,520
WAS 200 DAYS, DR. MOONY PUT THAT

4589
02:46:17,520 --> 02:46:18,988
IN A STARK CONTRAST TO THE

4590
02:46:18,988 --> 02:46:21,758
AVERAGE PHASE 3 TIMELINE OF 540

4591
02:46:21,758 --> 02:46:24,160
DAYS, SO REALLY DOING FAR BETTER

4592
02:46:24,160 --> 02:46:26,996
THAN EVEN OTHER INDUSTRY

4593
02:46:26,996 --> 02:46:30,667
SPONSORED STUDIES AND THERE WERE

4594
02:46:30,667 --> 02:46:32,836
IN ADVANCE CONCENTRATED EFFORTS

4595
02:46:32,836 --> 02:46:33,503
TO IMPLEMENT RECRUITMENT

4596
02:46:33,503 --> 02:46:35,305
STRATEGY AND THOSE MATERIALS

4597
02:46:35,305 --> 02:46:36,139
WERE DEVELOPED CONCURRENTLY FOR

4598
02:46:36,139 --> 02:46:38,675
WHEN THE STAT WAS BEING

4599
02:46:38,675 --> 02:46:40,877
ACTIVATED AND SO, THAT WAS AIAN

4600
02:46:40,877 --> 02:46:42,278
PARTICULARLY HELPFUL IN TERMS OF

4601
02:46:42,278 --> 02:46:43,613
BEING ABLE TO ENROLL THE

4602
02:46:43,613 --> 02:46:44,681
CLINICAL TRIAL, SO WHEN THE

4603
02:46:44,681 --> 02:46:45,782
TRIAL WAS DESEENED IT WAS

4604
02:46:45,782 --> 02:46:48,184
DESIGNED AS A TRIAL OF 700

4605
02:46:48,184 --> 02:46:49,853
PATIENTS, IT WOULD EXPECTED IT

4606
02:46:49,853 --> 02:46:52,522
WOULD TAKE 24 MONTHS TO INN ROLL

4607
02:46:52,522 --> 02:46:54,557
THAT STUDY AND WHEN DR. MOONY

4608
02:46:54,557 --> 02:46:55,825
PRESENTED THE DATA YESTERDAY, IT

4609
02:46:55,825 --> 02:46:57,494
WAS 15 MONTHS INTO THE TRIAL,

4610
02:46:57,494 --> 02:46:59,863
72% OF THAT GOAL HAS ALREADY

4611
02:46:59,863 --> 02:47:01,397
BEEN ACCRUED MUCH THE SAMPLE

4612
02:47:01,397 --> 02:47:03,666
SIZE IS LIKELY TO BE INCREASED

4613
02:47:03,666 --> 02:47:05,101
TO 800 PATIENTS WHEN HAVE WE

4614
02:47:05,101 --> 02:47:06,169
HEARD OF SOMETHING LIKE THAT

4615
02:47:06,169 --> 02:47:07,804
HAPPENING WHICH WILL ALLOW FOR

4616
02:47:07,804 --> 02:47:11,307
GREATER POWER, WHEN IT QUMS TO

4617
02:47:11,307 --> 02:47:13,042
BEING ABLE TO LOOK AT THE DAILY

4618
02:47:13,042 --> 02:47:14,844
BASIS AT AND SUBSET ANALYSIS OF

4619
02:47:14,844 --> 02:47:16,045
PATIENTSAs WELL, AND EACH WITH

4620
02:47:16,045 --> 02:47:17,213
TAKEN--THEY INCREASE IN SAMPLE

4621
02:47:17,213 --> 02:47:18,748
SIZE, THE ESTIMATES ARE THAT THE

4622
02:47:18,748 --> 02:47:22,218
STUDY WILL COMPLETE WITHIN THE 2

4623
02:47:22,218 --> 02:47:22,752
YEAR TIMELINE.

4624
02:47:22,752 --> 02:47:24,154
IN PARTICULAR, WHAT WAS VERY

4625
02:47:24,154 --> 02:47:26,322
COMPELLING TO ALL OF US

4626
02:47:26,322 --> 02:47:27,524
YESTERDAY WAS THE GROUP WHERE

4627
02:47:27,524 --> 02:47:28,792
THE PATIENTS WERE ENROLLED IN

4628
02:47:28,792 --> 02:47:30,660
THE STUDY THUS FAR, AND SO

4629
02:47:30,660 --> 02:47:41,204
COMPARING TO THE SEER DATABASE,

4630
02:47:42,739 --> 02:47:44,774
IT INCLUDED PATIENTS THAT WERE

4631
02:47:44,774 --> 02:47:46,442
AFRICAN AMERICAN, IT INCLUDED

4632
02:47:46,442 --> 02:47:48,311
PATIENTS WITH SIMILAR NUMBERS OF

4633
02:47:48,311 --> 02:47:51,047
LATINO PATIENT ANDS IT REALLY

4634
02:47:51,047 --> 02:47:52,916
SHOWED THAT WHEN YOU DO THESE

4635
02:47:52,916 --> 02:47:55,018
SIMPLIFIED TRIALS THAT WE REALLY

4636
02:47:55,018 --> 02:47:57,353
CAN ENHANCE THE DIVERSITY OF THE

4637
02:47:57,353 --> 02:47:58,621
KINDS OF PATIENTS ENROLLED AND

4638
02:47:58,621 --> 02:48:00,857
ALSO A VERY NICE ANALYSIS OF

4639
02:48:00,857 --> 02:48:03,026
RURAL VERSUS URBAN POPULATIONS

4640
02:48:03,026 --> 02:48:05,995
AND WE ALSO ARE ENROLLING

4641
02:48:05,995 --> 02:48:07,897
PATIENTS THAT ARE BUILDING ON OR

4642
02:48:07,897 --> 02:48:09,966
EQUAL TO WHAT'S IN THE SEER

4643
02:48:09,966 --> 02:48:11,601
DATABASE FOR RURAL POPULATIONS

4644
02:48:11,601 --> 02:48:12,769
WHICH IS AN IMPORTANT POPULATION

4645
02:48:12,769 --> 02:48:14,737
GROUP TO THINK ABOUT AS WELL.

4646
02:48:14,737 --> 02:48:17,006
AND SO DR. MOONY PRESENTED THIS

4647
02:48:17,006 --> 02:48:18,741
EXCITING DATA, WE THEN MOVED

4648
02:48:18,741 --> 02:48:19,475
INTO THE DISCUSSION PORTION

4649
02:48:19,475 --> 02:48:21,344
WHERE WE REALLY TARTED TALKING

4650
02:48:21,344 --> 02:48:22,812
ABOUT WHAT'S NEXT, NOW, SO WE

4651
02:48:22,812 --> 02:48:24,714
HAVE THIS REALLY SUCCESSFUL

4652
02:48:24,714 --> 02:48:26,282
MODEL, WHAT'S COMING NEXT, THERE

4653
02:48:26,282 --> 02:48:29,485
IS ALREADY A PLAN TRIAL IN THE

4654
02:48:29,485 --> 02:48:31,621
ADJUVANT LONG SETTING THAT

4655
02:48:31,621 --> 02:48:32,989
DR. MOONY DISCUSSED, THERE'S

4656
02:48:32,989 --> 02:48:33,957
ALSO A CLINICAL TRIALS

4657
02:48:33,957 --> 02:48:34,891
INVESTIGATION UNIT THAT STARTED

4658
02:48:34,891 --> 02:48:35,859
THIS YEAR, AND REALLY TAKEN ON

4659
02:48:35,859 --> 02:48:37,126
THE TASK OF TRYING TO FIGURE OUT

4660
02:48:37,126 --> 02:48:40,029
WHAT THE NEXT STEP SHOULD BE,

4661
02:48:40,029 --> 02:48:41,464
THERE WAS A CONSENSUS THAT WE

4662
02:48:41,464 --> 02:48:44,100
REALLY WANT TO FOCUS ON THINGS

4663
02:48:44,100 --> 02:48:46,069
THAT ARE EXCITING WHERE THE

4664
02:48:46,069 --> 02:48:49,105
SCIENTIFIC QUESTIONS AND

4665
02:48:49,105 --> 02:48:50,039
CLINICAL QUESTIONS ARE IMPORTANT

4666
02:48:50,039 --> 02:48:51,207
BUT WHERE WE CAN STILL ALSO

4667
02:48:51,207 --> 02:48:52,742
BUILD ON THE KIND OF DIVERSITY

4668
02:48:52,742 --> 02:48:55,745
WE HAVE IN THE STUDIES, WE ALSO

4669
02:48:55,745 --> 02:48:57,914
TALKED A LITTLE BIT ABOUT SOME

4670
02:48:57,914 --> 02:48:59,315
OF THE CHALLENGES OF PRAGMATIC

4671
02:48:59,315 --> 02:49:00,817
STUDY WHICH IS THAT YOU LOSE

4672
02:49:00,817 --> 02:49:03,486
DATA AND SO THERE WAS SOME

4673
02:49:03,486 --> 02:49:04,087
CONVERSATION ABOUT LOSING THE

4674
02:49:04,087 --> 02:49:06,356
OPPORTUNITY WHEN WE ARE

4675
02:49:06,356 --> 02:49:07,290
ENROLLING SUCH A DIVERSE

4676
02:49:07,290 --> 02:49:09,859
POPULATION TO MAYBE NOT GET THE

4677
02:49:09,859 --> 02:49:11,761
BIOSPECIMENS, WE'RE NOT GETTING

4678
02:49:11,761 --> 02:49:14,130
SOME OF THE QUALITY OF LIFE DATA

4679
02:49:14,130 --> 02:49:16,232
THAT WILL NICE TO HAVE A AND A

4680
02:49:16,232 --> 02:49:17,267
BALANCING ACT BETWEEN THAT, AND

4681
02:49:17,267 --> 02:49:18,234
WE TALKED ABOUT HOW WE CAN

4682
02:49:18,234 --> 02:49:20,336
CONTINUE TO COME UP WITH NEW

4683
02:49:20,336 --> 02:49:22,538
TREATMENT OPTIONS THAT WOE CAN

4684
02:49:22,538 --> 02:49:23,907
TEST, WE TALKED ABOUT THE IDEA

4685
02:49:23,907 --> 02:49:26,009
OF INVOLVING THE STEERING

4686
02:49:26,009 --> 02:49:27,143
COMMITTEE LEADERSHIP WHICH MIGHT

4687
02:49:27,143 --> 02:49:28,177
BE PARTICULARLY WELL SUITED TO

4688
02:49:28,177 --> 02:49:30,914
KNOW WHAT THE IMPORTANT

4689
02:49:30,914 --> 02:49:31,881
QUESTIONS ARE, AND OVERALL I

4690
02:49:31,881 --> 02:49:35,318
THINK WOE LEFT THAT MEETING VERY

4691
02:49:35,318 --> 02:49:36,085
HEARTENED BY THIS PARTICULAR

4692
02:49:36,085 --> 02:49:37,687
TRIAL AND WHAT IT REALLY MEANS

4693
02:49:37,687 --> 02:49:41,824
FOR THE FUTURE OF NCTN STUDIES

4694
02:49:41,824 --> 02:49:50,633
AND DOING PRAGMATIC TRIALS.

4695
02:49:50,633 --> 02:49:57,206
NFANTASTIC AND COMPELLING.

4696
02:49:57,206 --> 02:49:57,473
QUESTIONS?

4697
02:49:57,473 --> 02:49:58,875
>> SO I DIDN'T GET MY
QUESTION

4698
02:49:58,875 --> 02:50:00,410
BEFORE BUT IT'S PERFECT NOW, SO

4699
02:50:00,410 --> 02:50:02,145
I'M REFLECTING  ON WHAT KIM

4700
02:50:02,145 --> 02:50:04,080
ASKED US FOR AT THE END OF HER

4701
02:50:04,080 --> 02:50:07,183
TALK IS HOW DO WE ACCELERATE THE

4702
02:50:07,183 --> 02:50:09,919
PROGRESS AND DORPHY AND GET

4703
02:50:09,919 --> 02:50:11,421
PATIENTS ON STUDIES AND GET

4704
02:50:11,421 --> 02:50:13,189
DISCOVERIES OUT TO THE COMMUNITY

4705
02:50:13,189 --> 02:50:15,391
AND I'M REFLECTING ON OUR PRIOR

4706
02:50:15,391 --> 02:50:16,292
PRESENTATION AND THE

4707
02:50:16,292 --> 02:50:17,694
CONVERSATION LAST NIGHT WITH

4708
02:50:17,694 --> 02:50:20,096
PRAGMATICCA AND I THINK THAT'S

4709
02:50:20,096 --> 02:50:21,264
THE ROADMAP OF LIMITED

4710
02:50:21,264 --> 02:50:21,898
PARTNERSHIPPING FROM INDIVIDUAL

4711
02:50:21,898 --> 02:50:23,132
STUDIES THAT DO THIS WELL AND

4712
02:50:23,132 --> 02:50:26,135
WHAT ARE THE COMPONENTS OF THAT

4713
02:50:26,135 --> 02:50:28,137
WORK, GREETS THAT WORK IN THE

4714
02:50:28,137 --> 02:50:29,305
COMPELLING DATA PRESENTED BY

4715
02:50:29,305 --> 02:50:32,442
BOTH OUR LAST PRESENTERS,

4716
02:50:32,442 --> 02:50:33,409
PARTICULARLY DR. OCHOA'S

4717
02:50:33,409 --> 02:50:34,911
EVALUATION OF WHAT HE'S DOING

4718
02:50:34,911 --> 02:50:36,546
AND THAT'S ESSENTIAL AS WE MOVE

4719
02:50:36,546 --> 02:50:37,480
FORWARD.

4720
02:50:37,480 --> 02:50:39,349
SO, I DON'T KNOW IF THERE'S BEEN

4721
02:50:39,349 --> 02:50:40,516
A DEEP DIVE INTO PRAGMATIC LUNG

4722
02:50:40,516 --> 02:50:41,818
MOTTIC WE HEARD A DISCUSSION, I

4723
02:50:41,818 --> 02:50:43,820
DON'T KNOW IF THERE'S ACTUALLY

4724
02:50:43,820 --> 02:50:45,455
BEEN ANY EVALUATION BUT IF A

4725
02:50:45,455 --> 02:50:47,290
SECOND TRIAL IS SORT OF BEING

4726
02:50:47,290 --> 02:50:57,300
LAUNCHED IN THIS EFFORT,

4727
02:50:57,300 --> 02:50:59,669
EMBEDDING THAT PROJECT WITH

4728
02:50:59,669 --> 02:51:01,304
ACCRUAL THINGS TO STUDY, THAT

4729
02:51:01,304 --> 02:51:04,173
PROVIDES YOU WITH THE ROADMAP.

4730
02:51:04,173 --> 02:51:10,413
>> I AGREE, THE  DIAMONDS
ARE IN

4731
02:51:10,413 --> 02:51:11,280
THE DETAIL.

4732
02:51:11,280 --> 02:51:12,582
>> WAS THERE ANYTHING

4733
02:51:12,582 --> 02:51:13,850
IDENTIFIED, YOU MENTIONED THE

4734
02:51:13,850 --> 02:51:15,051
SHORT CONSENT FORM, NOT HAVING

4735
02:51:15,051 --> 02:51:25,561
TO REPORT, A LOT OF THE CATA.

4736
02:51:25,828 --> 02:51:28,731
WAS THERE ANY DATA ON THAT DATA

4737
02:51:28,731 --> 02:51:30,833
FOR WHAT CONTRIBUTED TO THE

4738
02:51:30,833 --> 02:51:32,201
INCREASED ACCRUAL, WAS THAT IT

4739
02:51:32,201 --> 02:51:34,670
OR MORE PEOPLE DOING MINORITY

4740
02:51:34,670 --> 02:51:40,543
CONSENTS OR WHAT IS KRIEWBING TO

4741
02:51:40,543 --> 02:51:40,777
THAT?

4742
02:51:40,777 --> 02:51:42,345
SO WE DIDN'T HEAR ANY OF THOSE

4743
02:51:42,345 --> 02:51:43,613
CATABECAUSE I DON'T WANT TO SAY

4744
02:51:43,613 --> 02:51:47,717
IT'S NOT BEING LOOKED AT AND

4745
02:51:47,717 --> 02:51:49,652
MAYBE DR. DOROSHOW MIGHT BE ABLE

4746
02:51:49,652 --> 02:51:50,953
TO ANSWER THAT QUESTION BUT THAT

4747
02:51:50,953 --> 02:51:52,622
WOULD BA I GREAT FOLLOW ON TO

4748
02:51:52,622 --> 02:51:54,257
THIS, SO TO ACTUALLY SURVEY THE

4749
02:51:54,257 --> 02:51:55,792
SEATS AND LOOK AND SEE WHICH OF

4750
02:51:55,792 --> 02:51:57,660
THESE THINGS ACTUALLY MADE MUCH

4751
02:51:57,660 --> 02:52:00,096
EASIER FOR YOU TO ENROLL IN THIS

4752
02:52:00,096 --> 02:52:01,664
TRIAL, BECAUSE, THERE WERE MANY

4753
02:52:01,664 --> 02:52:04,934
CHANGES THAT WERE MADE BASED ON

4754
02:52:04,934 --> 02:52:06,669
PREVIOUS, YOU KNOW PREVIOUS

4755
02:52:06,669 --> 02:52:07,670
FAILURES, BUT PREVIOUS

4756
02:52:07,670 --> 02:52:08,905
CHALLENGES, AND SO WHICH OF

4757
02:52:08,905 --> 02:52:18,081
THOSE WAS THE MOST USEFUL TO

4758
02:52:18,081 --> 02:52:20,550
THEM, TO WHAT THE DOCTOR WAS

4759
02:52:20,550 --> 02:52:20,983
SAYING.

4760
02:52:20,983 --> 02:52:23,386
>> SO WE HAVE ROY AND
SUSAN AND

4761
02:52:23,386 --> 02:52:23,586
CHECK.

4762
02:52:23,586 --> 02:52:25,721
>> SO I CAN TELL YOU AS A
RULING

4763
02:52:25,721 --> 02:52:28,191
TO THIS, 1 WORD SIMPLICITY.

4764
02:52:28,191 --> 02:52:29,392
THAT'S ALL IT IS.

4765
02:52:29,392 --> 02:52:32,261
AND SOMETIMES WE GET, 1 WAY JUST

4766
02:52:32,261 --> 02:52:36,332
OUT OF LONG STANDING PRACTICE,

4767
02:52:36,332 --> 02:52:37,700
SO WHEN PRAGMAT

4768
02:52:37,700 --> 02:52:39,302
CERTAINLY--CERTAINLIA LONG

4769
02:52:39,302 --> 02:52:40,236
STARTED AS PEOPLE STARTED

4770
02:52:40,236 --> 02:52:43,506
ENROLLING EVEN I AS A CLINICIAN,

4771
02:52:43,506 --> 02:52:45,875
THE SIMPLICITY OF THE WAS ALMOST

4772
02:52:45,875 --> 02:52:47,176
MIND BOGGLES AND WE WOULD GO

4773
02:52:47,176 --> 02:52:49,045
BACK AND SAY WELL, SURELY WE

4774
02:52:49,045 --> 02:52:51,714
HAVE TO DO CAT SCANS, NO, SCAN

4775
02:52:51,714 --> 02:52:54,350
SCATS BUT, BUT, THE FDA SAID

4776
02:52:54,350 --> 02:52:56,953
IT'S OKAY, IT'S OKAY, WE HAVE TO

4777
02:52:56,953 --> 02:52:57,386
TALK OURSELVES DOWN.

4778
02:52:57,386 --> 02:52:59,956
SO GOING TO THE NEXT STEP, THE

4779
02:52:59,956 --> 02:53:03,059
CTIU DID THIS PROPOSAL CALLED

4780
02:53:03,059 --> 02:53:06,162
FOR PROPOSALS, THERE IS A TRIAL

4781
02:53:06,162 --> 02:53:07,296
LONG PROSPECT LONG IS THE NAME

4782
02:53:07,296 --> 02:53:11,000
OF THE TRIAL AND ONCE IMEAN I

4783
02:53:11,000 --> 02:53:12,535
THINK WE ARE TRYING TO GET IN

4784
02:53:12,535 --> 02:53:14,036
OUR OWN WAY OUT OF OLD HEALTH

4785
02:53:14,036 --> 02:53:15,271
BENEFITS AND ACTUARIALETS.

4786
02:53:15,271 --> 02:53:16,939
O FOR EXAMPLE, PROSPECT LONG AND

4787
02:53:16,939 --> 02:53:20,309
SAD, THIS IS A VERY IMPORTANT

4788
02:53:20,309 --> 02:53:22,278
QUESTION WHEN PROPOSAL WAS MADE,

4789
02:53:22,278 --> 02:53:24,413
IT WAS--IT WAS DEEMED THAT VERY

4790
02:53:24,413 --> 02:53:28,384
INNOVATIVE TO TRY TO DO QUOTE

4791
02:53:28,384 --> 02:53:29,886
ENROLLMENTS ACROSS MULTIPLE

4792
02:53:29,886 --> 02:53:32,889
STUDIES TWHA WERE IN THE SAME

4793
02:53:32,889 --> 02:53:34,056
SPACE, BUT SUDDENLY WE GET THE

4794
02:53:34,056 --> 02:53:36,659
PUSH BACK FROM NETWORK CI, AND

4795
02:53:36,659 --> 02:53:37,593
CTEP, SAYING WELL, WE DON'T KNOW

4796
02:53:37,593 --> 02:53:38,928
IF THE AT THAT TIMES WILL WORK

4797
02:53:38,928 --> 02:53:42,098
OUT THIS WAY OR THE OTHER.

4798
02:53:42,098 --> 02:53:42,932
REMEMBER, REMEMBER, THIS IS

4799
02:53:42,932 --> 02:53:44,834
SUPPOSED TO BE PRAGMATIC, WE

4800
02:53:44,834 --> 02:53:47,703
NEED THE PATIENT IN THERE, LET'S

4801
02:53:47,703 --> 02:53:48,504
LEVERAGE--ANYWAY, I DON'T WANT

4802
02:53:48,504 --> 02:53:51,407
THIS TO BE A IMRIEP SESSION, I

4803
02:53:51,407 --> 02:53:52,942
THINK SOMETIMES, WE'RE SO DEEPLY

4804
02:53:52,942 --> 02:53:54,744
EMBEDDED IN THE OLD WAY OF DO

4805
02:53:54,744 --> 02:53:56,345
THINGS THAT WE CAN'T GET OUT OF

4806
02:53:56,345 --> 02:53:57,180
OUR WAY.

4807
02:53:57,180 --> 02:53:59,715
NYES NNETWORK KRRK I DIRECTORS

4808
02:53:59,715 --> 02:54:01,350
PREROGATIVE >>  YEAH, IN
JUST

4809
02:54:01,350 --> 02:54:02,752
WANT TO MAKE--YEAH JUST WANT TO

4810
02:54:02,752 --> 02:54:03,819
MAKERS AND A COMMENT TO THAT,

4811
02:54:03,819 --> 02:54:05,721
LET YOU KNOW THAT YOU KNOW THE

4812
02:54:05,721 --> 02:54:09,392
CTIU IS A YEAR OLD SO WE DECIDED

4813
02:54:09,392 --> 02:54:12,128
TO HAVE A RETREAT AND SEE WHAT'S

4814
02:54:12,128 --> 02:54:13,062
WORKING, WHAT'S NOT WORKING AND

4815
02:54:13,062 --> 02:54:16,766
WHAT DO WE NEED TO DO SO WE CAN

4816
02:54:16,766 --> 02:54:17,567
DO MORE.

4817
02:54:17,567 --> 02:54:20,603
AND I THINK BY THE WAY FDASCENT,

4818
02:54:20,603 --> 02:54:25,041
IT WAS A FAB FANTASTIC DAY AND

4819
02:54:25,041 --> 02:54:27,710
KIND OF THE BIG TAKE HOME IS

4820
02:54:27,710 --> 02:54:28,911
PROBABLY THAT WE'VE JUST DOWN 1

4821
02:54:28,911 --> 02:54:30,446
TRIAL AND SO WE NEED TO

4822
02:54:30,446 --> 02:54:34,383
PRACTICALIS, WE MEDE TO SEE

4823
02:54:34,383 --> 02:54:36,686
WHICH THINGS TO MAKE THESE KINDS

4824
02:54:36,686 --> 02:54:39,889
OF INNOVATIONS AND CHANGES IN

4825
02:54:39,889 --> 02:54:40,823
PRACTICE BECOME MORE, WE JUST

4826
02:54:40,823 --> 02:54:49,699
HAVE TO DO MORE. 

4827
02:54:49,699 --> 02:54:51,968
SO THAT'S COMING.

4828
02:54:51,968 --> 02:54:52,268
>> SUSAN.

4829
02:54:52,268 --> 02:54:53,369
>> YEAH, PIGGYBACKING  ON
SOME

4830
02:54:53,369 --> 02:54:55,204
OF THE EARLIER COMMENTS I ALSO

4831
02:54:55,204 --> 02:54:57,073
WONDER IF THIS IS AN OPPORTUNITY

4832
02:54:57,073 --> 02:54:59,475
TO PARTNER WITH THE EXCEPTIONAL

4833
02:54:59,475 --> 02:55:00,276
IMP LEMMATION SCIENCE

4834
02:55:00,276 --> 02:55:03,479
COLLEAGUES, THAT ARE HERE AT

4835
02:55:03,479 --> 02:55:05,648
NETWORK CI OR EXTERNALLY, TO

4836
02:55:05,648 --> 02:55:07,183
ALMOST DO LIKE A CORRELATIVE

4837
02:55:07,183 --> 02:55:11,187
STUDY OR A PARALLEL STUDY OF

4838
02:55:11,187 --> 02:55:12,388
WHAT WORKS AND REALLY SPEAKING

4839
02:55:12,388 --> 02:55:14,090
ABOUT THAT, YOU KNOW AS YOU'RE

4840
02:55:14,090 --> 02:55:16,859
ROLLING OUT LIKE THE NEW 3 SITES

4841
02:55:16,859 --> 02:55:18,828
THAT DR. DOROSHOW WAS TALKING

4842
02:55:18,828 --> 02:55:21,264
ABOUT, OR THE NEXT BIG TRIAL

4843
02:55:21,264 --> 02:55:22,565
RATHER THAN WONDERING ABOUT IT

4844
02:55:22,565 --> 02:55:25,101
AFTER THE FACT, HOW DO WE

4845
02:55:25,101 --> 02:55:26,469
INCORPORATE THAT AND I THINK

4846
02:55:26,469 --> 02:55:30,539
HAVE YOU THE EXPERTISE IN THIS

4847
02:55:30,539 --> 02:55:30,906
ROOM.

4848
02:55:30,906 --> 02:55:35,645
NCHUCK NI WILL KEEP THIS BRIEF

4849
02:55:35,645 --> 02:55:38,914
SINCE THIS PILOT, TO STERILIZED,

4850
02:55:38,914 --> 02:55:40,216
IT SOUNDS STERILIZED,

4851
02:55:40,216 --> 02:55:42,518
SIMPLIFIED, TREME LINED SO PART

4852
02:55:42,518 --> 02:55:44,987
OF OUR CHALLENGE WILL BE HOW DO

4853
02:55:44,987 --> 02:55:47,523
WE BUILD ON THIS PLATFORM AS WE

4854
02:55:47,523 --> 02:55:48,257
ADD COMPLEXITY.

4855
02:55:48,257 --> 02:55:49,892
NOT ALL TRIALS WILL LOOK LIKE

4856
02:55:49,892 --> 02:55:50,226
THIS.

4857
02:55:50,226 --> 02:55:52,428
HOW DO WE LEARN FROM THIS AND

4858
02:55:52,428 --> 02:55:54,196
LAYER UPON IT OTHER THINGS AND

4859
02:55:54,196 --> 02:56:00,136
SIMPLIFY THOSE OTHER THINGS, THE

4860
02:56:00,136 --> 02:56:02,004
IMANNUALING, DATA, AND HOW DO WE

4861
02:56:02,004 --> 02:56:03,105
DO THIS SOMATICALLY IN A PLANNED

4862
02:56:03,105 --> 02:56:08,444
WAY IT WOULD HELP US GET THAT.

4863
02:56:08,444 --> 02:56:10,946
>> I HAVE QUESTIONS BEFORE

4864
02:56:10,946 --> 02:56:13,582
MOVING ON, KAREN AND ANDY.

4865
02:56:13,582 --> 02:56:14,884
>> I WANT TO ALSO 1 OF THE

4866
02:56:14,884 --> 02:56:19,889
THINGS THAT STRUCK ME IS WILL

4867
02:56:19,889 --> 02:56:22,525
FACT THAT DR. MOONY TALKED ABOUT

4868
02:56:22,525 --> 02:56:25,061
THEY EDITED THE ELIGIBLE, THAT

4869
02:56:25,061 --> 02:56:31,400
HAS A HUGE REPERCUSSION FOR

4870
02:56:31,400 --> 02:56:32,568
ENABLING INCLUSIVE, AND THEY

4871
02:56:32,568 --> 02:56:34,003
ENCLOUD THINGS LIKE A BAMERICA I

4872
02:56:34,003 --> 02:56:35,104
OF LESS THAN 25, THAT'S NOT

4873
02:56:35,104 --> 02:56:36,372
GOING TO HAPPEN IN THE U.S.,

4874
02:56:36,372 --> 02:56:37,940
RIGHT IN SO PART OF WHAT WE NEED

4875
02:56:37,940 --> 02:56:39,575
TO DO THAT'S THE PRACTICAL THING

4876
02:56:39,575 --> 02:56:40,910
SO I LOVE THE FACT THAT YOU'RE

4877
02:56:40,910 --> 02:56:43,412
TALKING ABOUT INN CLUING THE

4878
02:56:43,412 --> 02:56:44,146
IMPLEMENTATION SCIENCE GROUP TO

4879
02:56:44,146 --> 02:56:47,016
SAY, WHAT ARE THE THINGS THAT WE

4880
02:56:47,016 --> 02:56:48,651
CAN AVOID, LIKE THAT WE CAN

4881
02:56:48,651 --> 02:56:50,619
REALLY TAKE OUT, THAT DON'T

4882
02:56:50,619 --> 02:56:51,587
IMPACT, YOU KNOW THE OUTCOMES OF

4883
02:56:51,587 --> 02:56:53,789
STUDIES AND I THINK THAT IS A

4884
02:56:53,789 --> 02:56:57,326
REALLY IMPORTANT THING TO JUST

4885
02:56:57,326 --> 02:56:57,693
MENTION.

4886
02:56:57,693 --> 02:56:58,494
>> GREAT, LAST QUESTION.

4887
02:56:58,494 --> 02:57:01,831
NI GUESS REALLY WANTED TO SORT

4888
02:57:01,831 --> 02:57:03,766
OF HIGHLIGHT THE CHALLENGE YOU

4889
02:57:03,766 --> 02:57:06,235
BROUGHT OUT ABOUT BALANCING A

4890
02:57:06,235 --> 02:57:07,269
COMPLEXITY AND PRAGMATIC STYLE

4891
02:57:07,269 --> 02:57:14,944
WHEN IT COMES TO THINGS LIKE

4892
02:57:14,944 --> 02:57:15,444
BIOSPECIMENS AND

4893
02:57:15,444 --> 02:57:16,112
BIOREPOSITORIES, BECAUSE WE NEED

4894
02:57:16,112 --> 02:57:17,546
TO THINK ABOUT VALUE WITH THESE

4895
02:57:17,546 --> 02:57:20,049
AND HOW THEY CAN CONTRIBUTE TO

4896
02:57:20,049 --> 02:57:20,282
SCIENCE.

4897
02:57:20,282 --> 02:57:22,284
SO IN JUST SOME OF THE

4898
02:57:22,284 --> 02:57:23,786
QUALITATIVE WORK I'VE HEARD, I

4899
02:57:23,786 --> 02:57:26,455
THINK THIS' AN ASUMP THAT

4900
02:57:26,455 --> 02:57:27,289
BIOSPECIMENS CLICKING THOSE

4901
02:57:27,289 --> 02:57:28,557
SPECIMENS IS A BIRRIER

4902
02:57:28,557 --> 02:57:29,959
SURFACESSIER, WE SHOULD

4903
02:57:29,959 --> 02:57:30,659
CHALLENGE THAT.

4904
02:57:30,659 --> 02:57:32,294
WHETHER THAT'S REALLY TRUE AND

4905
02:57:32,294 --> 02:57:34,497
IT DO SOME OF THE WORK THAT

4906
02:57:34,497 --> 02:57:39,602
PEOPLE PROPOSED HERE, DO

4907
02:57:39,602 --> 02:57:40,403
CORRELATIVE STUDIES TO

4908
02:57:40,403 --> 02:57:41,470
UNDERSTAND THE BARRIERS TO

4909
02:57:41,470 --> 02:57:43,939
THOSE, SO WE CAN DIVERSIFY

4910
02:57:43,939 --> 02:57:45,641
BIOBANDS AND MAKE THEM ABLE TO  

4911
02:57:45,641 --> 02:57:46,842
PERFORM THE SCIENCE AND PLAN

4912
02:57:46,842 --> 02:57:49,311
BETTER TRIALS IN THE FUTURE.

4913
02:57:49,311 --> 02:57:53,182
NOKAY, THANKS, THANKS ANDY. 

4914
02:57:53,182 --> 02:57:56,185
SO GREAT PRESENTATION, MILO, SO

4915
02:57:56,185 --> 02:57:58,254
THE NCAB MEMBERS WILL NEED TO

4916
02:57:58,254 --> 02:57:59,989
VOTE TO ACCEPT THE REPORT, IS

4917
02:57:59,989 --> 02:58:04,827
THERE A MOTION IN.

4918
02:58:04,827 --> 02:58:06,228
>> MOTION.

4919
02:58:06,228 --> 02:58:06,529
>> SECOND.

4920
02:58:06,529 --> 02:58:10,499
>> MOVED AND SECOND. 

4921
02:58:10,499 --> 02:58:11,534
>> ANY FURTHER DISCUSSION?

4922
02:58:11,534 --> 02:58:13,235
IF THERE IS NONE, WE SHOULD VOTE

4923
02:58:13,235 --> 02:58:20,943
ARE THERE ANY NAYS?

4924
02:58:20,943 --> 02:58:21,277
ABSTENTIONS?

4925
02:58:21,277 --> 02:58:21,544
UNANIMOUS.

4926
02:58:21,544 --> 02:58:24,513
SO MOVING ON TO THE NEXT

4927
02:58:24,513 --> 02:58:26,248
SUBCOMMITTEE REPORT, ON THE AD

4928
02:58:26,248 --> 02:58:28,984
HOC SUBCOMMITTEE ON POPULATION

4929
02:58:28,984 --> 02:58:29,718
SCIENCE EPIDEMIOLOGY AND

4930
02:58:29,718 --> 02:58:32,955
DISPARITIES WILL BE PROVIDED BY

4931
02:58:32,955 --> 02:58:33,289
DR. WINKFIELD.

4932
02:58:33,289 --> 02:58:34,690
>> THANK YOU SO MUCH JOHN
AND

4933
02:58:34,690 --> 02:58:36,459
THANK YOU SO MUCH FOR EVERYBODY

4934
02:58:36,459 --> 02:58:37,259
WHO PARTICIPATED LAST NIGHT.

4935
02:58:37,259 --> 02:58:47,703
WE HAD A FULL HOUSE WHICH WAS

4936
02:58:47,703 --> 02:58:48,771
FANTASTIC, THERE WERE FOLKS

4937
02:58:48,771 --> 02:58:50,072
THERE THAT WERE NOT SUBCOMMITTEE

4938
02:58:50,072 --> 02:58:51,540
MEMBERS SO I WANT TO THANK YOU

4939
02:58:51,540 --> 02:58:52,541
ALL FOR PARTICIPATE NOTHING

4940
02:58:52,541 --> 02:58:53,642
PERSON, IT'S IMPORTANT TO HAVE

4941
02:58:53,642 --> 02:58:54,944
YOUR VOICE AND IT'S INVALUABLE

4942
02:58:54,944 --> 02:58:56,679
AND 1 OF THE THINGS THAT I FIRST

4943
02:58:56,679 --> 02:58:58,681
DID WAS TO REMIND FOLKS OF WHAT

4944
02:58:58,681 --> 02:58:59,648
THE SUBCOMMITTEE IS ABOUT,

4945
02:58:59,648 --> 02:59:02,251
BECAUSE I THINK TIMES THAT CAN

4946
02:59:02,251 --> 02:59:04,286
GET LOST, WE OFTEN TIMES WILL

4947
02:59:04,286 --> 02:59:05,321
TALK ABOUT SUBCOMMITTEES BUT THE

4948
02:59:05,321 --> 02:59:06,622
CHARGE OF THIS PARTICULAR

4949
02:59:06,622 --> 02:59:07,590
SUBCOMMITTEE IS REALLY TO ADVISE

4950
02:59:07,590 --> 02:59:09,291
ON SOME OF THE STRAY JECTORY

4951
02:59:09,291 --> 02:59:10,459
TEENINGIC APPROACHES AND

4952
02:59:10,459 --> 02:59:12,328
OPPORTUNITIES TO ENHANCE

4953
02:59:12,328 --> 02:59:14,163
NCIEYE'S CONTRIBUTION TO

4954
02:59:14,163 --> 02:59:15,130
POPULATION SCIENCE, EPIDEM

4955
02:59:15,130 --> 02:59:16,398
IMROLG AND DIVERSITY, SO THE

4956
02:59:16,398 --> 02:59:18,067
SUBNITRIC OXIDEEE IS RESPONSIBLE

4957
02:59:18,067 --> 02:59:19,301
FOR IESHES DENTIFYING

4958
02:59:19,301 --> 02:59:20,970
OPPORTUNITIES TO ADDRESS

4959
02:59:20,970 --> 02:59:22,605
POPULATIONS FACING DISPARITIES

4960
02:59:22,605 --> 02:59:23,205
THROUGH MULTIDISCIPLINARY

4961
02:59:23,205 --> 02:59:26,075
PROGRAM ANDS RESEARCH

4962
02:59:26,075 --> 02:59:27,209
SURVEILLANCE, PATIENT CARE,

4963
02:59:27,209 --> 02:59:28,377
PRIMARY PRERENGZ, EDUCATION AND

4964
02:59:28,377 --> 02:59:29,778
CANCER CONTROL.

4965
02:59:29,778 --> 02:59:31,747
SO IT'S A WIDE SWATH OF THINGS

4966
02:59:31,747 --> 02:59:33,716
THAT REALLY JUST A SUBCOMMITTEE

4967
02:59:33,716 --> 02:59:35,818
IS REASONABLY RESPONSIBLE FOR

4968
02:59:35,818 --> 02:59:36,785
REALLY HELPING TO ADVISE ON AND

4969
02:59:36,785 --> 02:59:37,853
PART OF THE STRAY JECTORY EDGY

4970
02:59:37,853 --> 02:59:39,255
WAS TO SAY, WELL WHAT IS NETWORK

4971
02:59:39,255 --> 02:59:41,457
KRRK I ALREADY DOING IN SOME OF

4972
02:59:41,457 --> 02:59:43,959
THESE SPACES SO IN THE LAST

4973
02:59:43,959 --> 02:59:46,028
MEETING WE ACTUALLY HAD SOMEONE

4974
02:59:46,028 --> 02:59:48,697
COME, DR. GOD ARD COME AND TALK

4975
02:59:48,697 --> 02:59:49,632
ABOUT SOCIAL DETERMINANTS OF

4976
02:59:49,632 --> 02:59:51,634
HEALTH AND NIH WIDE INITIATIVE

4977
02:59:51,634 --> 02:59:53,402
TO HELP DEFINE WHAT THE SOCIAL

4978
02:59:53,402 --> 02:59:54,970
DETERMINANTS OF HEALTH ARE AND

4979
02:59:54,970 --> 02:59:56,505
WHERE THE METRICS WE NEED TO BE

4980
02:59:56,505 --> 02:59:57,106
INCLUDING IN SOME OF THE

4981
02:59:57,106 --> 02:59:58,941
RESEARCH AND SO THIS TIME WE

4982
02:59:58,941 --> 03:00:00,009
WANTED TO GIVE AN OPPORTUNITY TO

4983
03:00:00,009 --> 03:00:01,176
TALK ABOUT SOME OTHER THINGS

4984
03:00:01,176 --> 03:00:04,580
THAT HAVE BEEN HIGH PRIORITY IPT

4985
03:00:04,580 --> 03:00:07,716
GREATER CLUING MSET TESTING O

4986
03:00:07,716 --> 03:00:09,318
MCDs, THEE MULTICANCKER

4987
03:00:09,318 --> 03:00:10,519
DETECTION TESTS, AND WE HAD A

4988
03:00:10,519 --> 03:00:12,388
DOCTOR WHO WAS THE DIRECTOR OF

4989
03:00:12,388 --> 03:00:14,590
CANCER PREVENTION COME AND GIVE

4990
03:00:14,590 --> 03:00:16,025
A PRESENTATION, GIVE AACR AND I

4991
03:00:16,025 --> 03:00:16,992
THOUGHT IT WAS REALLY IMPORTANT

4992
03:00:16,992 --> 03:00:20,829
FOR THIS GROUP TO ACTUALLY HEAR

4993
03:00:20,829 --> 03:00:22,798
AGAIN AND REALLY TO TALK ABOUT

4994
03:00:22,798 --> 03:00:25,901
HOW THE IN, CI'S INTERESTED IN

4995
03:00:25,901 --> 03:00:29,672
EVALUATING SOME OF THESE NOVEL

4996
03:00:29,672 --> 03:00:30,839
BLOOD BASED MULTICANCKER

4997
03:00:30,839 --> 03:00:32,341
DETECTION TESTS AND HE STARTED

4998
03:00:32,341 --> 03:00:34,076
OUT BY SAYING THIS IS A HUGE

4999
03:00:34,076 --> 03:00:35,611
OCEAN AND WE'RE NOT CLEAR WHICH

5000
03:00:35,611 --> 03:00:37,846
1 OF THESE MCDs WILL BE

5001
03:00:37,846 --> 03:00:38,414
PROMISING.

5002
03:00:38,414 --> 03:00:39,381
WILL THEY HAVE THE IMPACT THAT

5003
03:00:39,381 --> 03:00:40,683
WE THINK THEY WILL HAVE AND SO

5004
03:00:40,683 --> 03:00:42,318
IT WAS REALLY IMPORTANT FOR HIS

5005
03:00:42,318 --> 03:00:44,587
GROUP TO REALLY TART TO SAY, HOW

5006
03:00:44,587 --> 03:00:47,423
DO THESE TESTS ACTUALLY PROVIDE

5007
03:00:47,423 --> 03:00:50,192
ANY CLINICAL BENEFIT, HOW CAN

5008
03:00:50,192 --> 03:00:52,161
HE--THE NCI BE AN HONEST BROKER

5009
03:00:52,161 --> 03:00:54,129
IF YOU WILL, OF DIFFERENTIATING

5010
03:00:54,129 --> 03:00:56,799
BETWEEN SOME OF THESE TESTS, AND

5011
03:00:56,799 --> 03:00:57,766
REALLY SAYS THAT IT WAS

5012
03:00:57,766 --> 03:01:02,938
IMPORTANT AND I THINK THIS WAS A

5013
03:01:02,938 --> 03:01:04,773
KEY MESSAGE THAT THESE NSAID ARE

5014
03:01:04,773 --> 03:01:06,542
ARE PART OF A CONTINUUM OF CARE,

5015
03:01:06,542 --> 03:01:08,577
ANYTIME WE THINK ABOUT SCREENING

5016
03:01:08,577 --> 03:01:12,715
FOR CANCER IT'S JUST 1

5017
03:01:12,715 --> 03:01:12,982
COMPONENT.

5018
03:01:12,982 --> 03:01:14,350
IF YOU SCREEN AND DON'T DO

5019
03:01:14,350 --> 03:01:15,884
ANYTHING WITH RESPECT TO

5020
03:01:15,884 --> 03:01:17,319
DIAGNOSTICS, WHAT ARE WE DOING?

5021
03:01:17,319 --> 03:01:18,721
IF WE SCREEN PEOPLE AND THEN

5022
03:01:18,721 --> 03:01:21,824
DON'T HAVE A WAY FOR THEM TO GET

5023
03:01:21,824 --> 03:01:22,791
THE TREATMENT THEY NEED, WE'RE

5024
03:01:22,791 --> 03:01:24,660
WHAT ARE WE DOING?

5025
03:01:24,660 --> 03:01:26,495
WE CAN EXACERBATE SOME OF THE

5026
03:01:26,495 --> 03:01:30,265
DISPARITIES AND SO YOU ALREADY

5027
03:01:30,265 --> 03:01:33,002
HEARD DR. RATHMILL TALK ABOUT

5028
03:01:33,002 --> 03:01:35,738
THE VANGUARD STUDY BREAFLY AND

5029
03:01:35,738 --> 03:01:36,672
DR. CASSELL SPLEANED MORE ABOUT

5030
03:01:36,672 --> 03:01:38,874
VAN GUARD BUT HE FIRST PREFACED

5031
03:01:38,874 --> 03:01:40,843
IT BY TALKING ABOUT SHIP, THE

5032
03:01:40,843 --> 03:01:42,678
OTHER STUDY THAT THEY TALKED

5033
03:01:42,678 --> 03:01:44,113
ABOUT AND THAT'S THE 1 WHERE HIS

5034
03:01:44,113 --> 03:01:45,381
GROUP IS LOOKING AT CIRCLE

5035
03:01:45,381 --> 03:01:47,950
CANCER KREENING AND HOW CAN WE

5036
03:01:47,950 --> 03:01:49,018
ACTUALLY ALLOW AND EMPOWER,

5037
03:01:49,018 --> 03:01:52,121
INDIVIDUALS AND PATIENTS TO

5038
03:01:52,121 --> 03:01:52,855
ACTUALLY SELF-SCREEN, RIGHT, HOW

5039
03:01:52,855 --> 03:01:54,957
DO WE DOP THAT AND AGAIN THAT'S

5040
03:01:54,957 --> 03:01:56,258
JUST A KREENING COMPONENT AND 1

5041
03:01:56,258 --> 03:01:58,027
OF THE LESSONS LEARNED AGAIN IS

5042
03:01:58,027 --> 03:01:59,228
THAT SCREENING IS JUST 1 PART,

5043
03:01:59,228 --> 03:02:01,196
WHAT HAPPEN FIST THERE'S A

5044
03:02:01,196 --> 03:02:02,564
POSITIVE FINDING, DO WOE HAVE

5045
03:02:02,564 --> 03:02:03,766
THE TIEWPT TO CONNECK PEOPLE

5046
03:02:03,766 --> 03:02:05,601
WITH THE SERVICES THEY NEED FROM

5047
03:02:05,601 --> 03:02:06,535
A DIAGNOVARTIS NUMBER OF THETIC

5048
03:02:06,535 --> 03:02:07,703
AND ALSO A TREATMENT STANDPOINT

5049
03:02:07,703 --> 03:02:09,705
BUT I THINK THAT SHIP TRIAL IS 1

5050
03:02:09,705 --> 03:02:11,473
OF THE THINGS WE REALLY NEED TO

5051
03:02:11,473 --> 03:02:13,876
KEEP AN EYE ON BECAUSE IT WILL

5052
03:02:13,876 --> 03:02:15,177
REALLY EMON SPHRAIT SOME OF THE

5053
03:02:15,177 --> 03:02:17,279
GAPS IN TERMS OF THE CARE THAT

5054
03:02:17,279 --> 03:02:18,447
POPULATIONS PARTICULARLY THOSE

5055
03:02:18,447 --> 03:02:21,984
WHO HAVE BEEN TRADITIONALLY

5056
03:02:21,984 --> 03:02:24,720
DISADVANTAGED WHERE THEY'RE IN

5057
03:02:24,720 --> 03:02:26,922
RURAL COMMUNITIES OR COMMUNITIES

5058
03:02:26,922 --> 03:02:29,124
OF COLOR, WE WILL WEEP AN EYE ON

5059
03:02:29,124 --> 03:02:31,060
THAT AND THEN WITH RESPECT TO

5060
03:02:31,060 --> 03:02:32,428
THE VANGUARD STUDY THAT ENCLUEDS

5061
03:02:32,428 --> 03:02:34,863
7 CENTERS AND ALSO THE U.S.

5062
03:02:34,863 --> 03:02:36,265
DEPARTMENT OF DEFENSE, U.S.

5063
03:02:36,265 --> 03:02:41,003
DEPARTMENT OF VETERAN AFFAIRS,

5064
03:02:41,003 --> 03:02:42,638
IT'S A LOT OF THESE INCORPORATED

5065
03:02:42,638 --> 03:02:43,939
INTO THE CENTERS WHICH IS AN

5066
03:02:43,939 --> 03:02:45,207
IMPORTANT THING AND 1 OF THE

5067
03:02:45,207 --> 03:02:46,408
THINGS THAT WE'RE THEEPING TO DO

5068
03:02:46,408 --> 03:02:47,576
IS CREATE AND MOVE FORWARD A

5069
03:02:47,576 --> 03:02:49,812
LODGE LAT FORM THAT CAN PROVIDE

5070
03:02:49,812 --> 03:03:00,322
SOME RANDOMIZED CONTROL TRIALS

5071
03:03:03,258 --> 03:03:10,299
RELATED TO NSAID USE, BUT IT'S

5072
03:03:10,299 --> 03:03:11,366
REALLY TO IMPLEMENT STRATEGIES

5073
03:03:11,366 --> 03:03:12,901
TO ENABLE US TO THINK ABOUT THE

5074
03:03:12,901 --> 03:03:20,175
ENTIRE CONTINUUM OF CARE.

5075
03:03:20,175 --> 03:03:22,511
SO WE REALLY HAD A GREAT ROBUST

5076
03:03:22,511 --> 03:03:23,779
DISCUSSION ABOUT THAT, WE COULD

5077
03:03:23,779 --> 03:03:25,514
HAVE TALKED LONGER AND 1 THINK

5078
03:03:25,514 --> 03:03:29,251
THIS THAT MR. RON WHO ASKED THE

5079
03:03:29,251 --> 03:03:37,860
QUESTION WHO ASKED HOW WOULD

5080
03:03:37,860 --> 03:03:40,496
DR. RATHMILL WHO'S BEEN DOING

5081
03:03:40,496 --> 03:03:42,231
THIS, I THINK IT'S AGAIN

5082
03:03:42,231 --> 03:03:43,398
IMPORTANT TO NOTE IT'S ABOUT THE

5083
03:03:43,398 --> 03:03:44,700
COMMUNITIES WE NEED TO ASK THE

5084
03:03:44,700 --> 03:03:45,667
REQUEST COMMUNITIES HOW DO WE DO

5085
03:03:45,667 --> 03:03:47,102
THIS AND HOW DO WE PROMOTE THE

5086
03:03:47,102 --> 03:03:48,403
KREENING AND THAT WAS A HUGE

5087
03:03:48,403 --> 03:03:49,238
COMPONENT OF THE SOME OF THE

5088
03:03:49,238 --> 03:03:50,339
WORK SO PART OF WHAT THE

5089
03:03:50,339 --> 03:03:51,507
SUBCOMMITTEE WILL HAVE TO DO IS

5090
03:03:51,507 --> 03:03:54,476
THINK ABOUT WHAT ISLET RESOURCE

5091
03:03:54,476 --> 03:03:56,278
TO MOVE THAT FORWARD AND HOW DO

5092
03:03:56,278 --> 03:03:57,212
WE INCORPORATE THE COMMUNITY

5093
03:03:57,212 --> 03:03:57,946
INTO OUR RESEARCH GOING FORWARD

5094
03:03:57,946 --> 03:04:02,050
AND THAT WILL BE GREAT.

5095
03:04:02,050 --> 03:04:04,353
AND THEN SECONDLY WE HAD A

5096
03:04:04,353 --> 03:04:05,854
WONDER OF DISCUSSION BY

5097
03:04:05,854 --> 03:04:06,555
DR. SONIA SPRING FIELD WHO WE

5098
03:04:06,555 --> 03:04:09,892
KNOW IS THE DIRECTOR EVER FOR

5099
03:04:09,892 --> 03:04:11,760
THE VERY NEW CENTER FOR CANCER

5100
03:04:11,760 --> 03:04:13,862
HEALTH EQUITY AND SHE ACTUALLY

5101
03:04:13,862 --> 03:04:15,430
PROVIDED SOME RATIONAL FOR THE

5102
03:04:15,430 --> 03:04:16,698
NAME CHANGE WHICH AS YOU HEARD

5103
03:04:16,698 --> 03:04:18,500
IT MOVES FROM DESCRIBING THE

5104
03:04:18,500 --> 03:04:19,902
NEGATIVES BUT SAYING WHAT IS IT

5105
03:04:19,902 --> 03:04:21,203
THAT THAT WE CAN ALL DO AND MOVE

5106
03:04:21,203 --> 03:04:22,371
THINGS INTO A POSITIVE DIRECTION

5107
03:04:22,371 --> 03:04:24,640
AND WHAT ARE THE WAYS WE CAN

5108
03:04:24,640 --> 03:04:25,340
ACTUALLY ELEVATE COMMUNITIES,

5109
03:04:25,340 --> 03:04:27,643
BUT THEN ALSO TALKED ABOUT SOME

5110
03:04:27,643 --> 03:04:28,977
OF THE RESTRUCTURE THAGOREAN'S

5111
03:04:28,977 --> 03:04:32,447
TAKEN PLACE BECAUSE SOME OF THE

5112
03:04:32,447 --> 03:04:33,615
PROGRAMMATIC WORK REALLY KIND OF

5113
03:04:33,615 --> 03:04:35,484
FITS WITH SOME OF THE NAME

5114
03:04:35,484 --> 03:04:36,685
CHANGES WITH RESPECT TO EQUITY

5115
03:04:36,685 --> 03:04:39,221
AND SO, YOU KNOW SHE TALKED

5116
03:04:39,221 --> 03:04:42,191
ABOUT THE CCAG CORE WHICH IS

5117
03:04:42,191 --> 03:04:45,828
SEEKING TO EXPLORE STRATEGIES

5118
03:04:45,828 --> 03:04:48,096
FOR EQUITABLE PARTICIPATION FOR

5119
03:04:48,096 --> 03:04:49,731
UPDATER SERVED COMMUNITIES BY

5120
03:04:49,731 --> 03:04:51,800
DIRECTION AND CANCER DISPARITIES

5121
03:04:51,800 --> 03:04:52,067
RESEARCH.

5122
03:04:52,067 --> 03:04:54,002
MANY FOLKS KNOW ABOUT THE CURE

5123
03:04:54,002 --> 03:04:54,903
PROGRAMS WHICH FITS UNDERNEELGT

5124
03:04:54,903 --> 03:04:57,039
THERE, ALSO KIND OF TALKING

5125
03:04:57,039 --> 03:05:00,609
ABOUT THE TEAM WHICH IS

5126
03:05:00,609 --> 03:05:01,343
TRANSFORMATIONAL EDUCATIONAL

5127
03:05:01,343 --> 03:05:02,311
ADVANCEMENT AND MENTORING

5128
03:05:02,311 --> 03:05:03,045
NETWORK, AND REALLY IMPORTANT TO

5129
03:05:03,045 --> 03:05:04,246
MAKE SURE WE'RE PAIRING THOSE

5130
03:05:04,246 --> 03:05:05,948
EARLY STAGE VERY LONGS YOU TALK

5131
03:05:05,948 --> 03:05:07,216
ABOUT, WITH OTHER INDIVIDUALS

5132
03:05:07,216 --> 03:05:09,051
WHO CAN HELP MENTOR THEM ALONG

5133
03:05:09,051 --> 03:05:11,220
THE ENTIRE RESEARCH CONTINUUM,

5134
03:05:11,220 --> 03:05:12,187
BUT SHE ALSO KIND OF TALKED

5135
03:05:12,187 --> 03:05:15,457
ABOUT SOME OF THE OTHER

5136
03:05:15,457 --> 03:05:16,792
DIFFERENT COMPONENTS OF THE

5137
03:05:16,792 --> 03:05:18,093
CCHE, I WILL NOT GO THROUGH IT

5138
03:05:18,093 --> 03:05:19,194
BECAUSE YOU WILL IMET NOTES ON

5139
03:05:19,194 --> 03:05:20,462
THIS, BUT I THOUGHT IT WAS

5140
03:05:20,462 --> 03:05:21,864
REALLY IMPORTANT AGAIN FOR US TO

5141
03:05:21,864 --> 03:05:23,832
UNDERSTAND THE DEPTH AND BREDTH

5142
03:05:23,832 --> 03:05:25,500
OF WHAT THE CCAT DOES, SO THAT

5143
03:05:25,500 --> 03:05:27,469
WE CAN SAY, HOW DO WE LEVERAGE

5144
03:05:27,469 --> 03:05:30,706
THAT, HOW DO WE ACTUALLY TAKE

5145
03:05:30,706 --> 03:05:31,773
WHAT'S ALREADY EXISTING

5146
03:05:31,773 --> 03:05:32,441
INFRASTRUCTURE WITHIN THE NCLRKS

5147
03:05:32,441 --> 03:05:35,577
I AND SAY HOW DO WE LEVERAGE

5148
03:05:35,577 --> 03:05:37,646
WHAT DR. SPRING FIELD'S GROUP

5149
03:05:37,646 --> 03:05:39,514
DOING TO THINK ABOUT POPULATION

5150
03:05:39,514 --> 03:05:40,449
HEALTH IN A DIFFERENT WAY AND

5151
03:05:40,449 --> 03:05:50,993
MAKE ITS SO THAT WE ARE WORKING

5152
03:05:56,098 --> 03:05:56,565
COLLABORATIVELY.

5153
03:05:56,565 --> 03:05:57,699
AMERICA REALLY RYED TO LEVERAGE

5154
03:05:57,699 --> 03:05:59,902
THE THINGS THAT ARE HAPPENING IN

5155
03:05:59,902 --> 03:06:01,236
CCHE, THAT ARE HAPPENING IN

5156
03:06:01,236 --> 03:06:03,839
SILOED PART OF THE NCI TO WORK

5157
03:06:03,839 --> 03:06:04,640
COLLABORATIVELY TOGETHER AND

5158
03:06:04,640 --> 03:06:05,741
HELP ANSWER THESE IMPORTANT

5159
03:06:05,741 --> 03:06:06,041
QUESTIONS.

5160
03:06:06,041 --> 03:06:07,876
ONE OF THE OTHER THINGS THAT

5161
03:06:07,876 --> 03:06:09,044
DR. SPRING FIELD DID TALK ABOUT

5162
03:06:09,044 --> 03:06:10,846
IN ADDITION TO THE CANCER

5163
03:06:10,846 --> 03:06:11,914
MOONSHOT SCHOLARS PROGRAM WHICH

5164
03:06:11,914 --> 03:06:15,651
IS FANTASTIC AND SUPPORTED BY

5165
03:06:15,651 --> 03:06:16,818
THE WHITE HOUSE, IT IS REALLY

5166
03:06:16,818 --> 03:06:17,552
ALSO TALKING ABOUT THE

5167
03:06:17,552 --> 03:06:21,223
IMPORTANCE OF THIS NEWLY SPRUCED

5168
03:06:21,223 --> 03:06:22,291
CANCER EQUITY LEADERSHIP GROUP

5169
03:06:22,291 --> 03:06:25,160
OR LEADERS BROWP THAT

5170
03:06:25,160 --> 03:06:26,662
DR. RATHMILL DISCUSSED REALLY

5171
03:06:26,662 --> 03:06:27,863
IMPORTANT TO KIND OF START TO

5172
03:06:27,863 --> 03:06:29,398
RETHINK, IF WE'RE GOING TO

5173
03:06:29,398 --> 03:06:32,301
REALLY GET TO THE POINT WHERE

5174
03:06:32,301 --> 03:06:33,835
EQUITY IS TRULY A MOAJOR

5175
03:06:33,835 --> 03:06:35,837
COMPONENT OF WHAT WE'RE REACHING

5176
03:06:35,837 --> 03:06:37,539
FOR AND STRATEGIZING ABOUT HOW

5177
03:06:37,539 --> 03:06:40,442
DO WE KIND OF PULL IN ALL

5178
03:06:40,442 --> 03:06:41,643
COMPONENTS AGAIN, WE HAVE CANCER

5179
03:06:41,643 --> 03:06:44,379
CENTER DIRECTOR WHO IS ARE PART

5180
03:06:44,379 --> 03:06:47,549
OF THE SALE, THERE ARE

5181
03:06:47,549 --> 03:06:48,283
INSTITUTION TRUSTEESS THAT ARE

5182
03:06:48,283 --> 03:06:50,752
PART OF CELL AND HOW CAN WE

5183
03:06:50,752 --> 03:06:52,054
PUBLISHED TLGT THIS CADRE OF

5184
03:06:52,054 --> 03:06:54,356
INDIVIDUALS WHO NOT ONLY

5185
03:06:54,356 --> 03:06:54,957
REPRESENT DIFFERENT DIVERSE

5186
03:06:54,957 --> 03:06:56,825
COMMUNITIES BUT CAN BE LEVERAGED

5187
03:06:56,825 --> 03:06:58,894
AS ROLE MODELS BUT ALSO THEIR

5188
03:06:58,894 --> 03:07:01,263
EXPERTISE IN HOW THEY GOT FROM

5189
03:07:01,263 --> 03:07:03,131
.8 TO POINT B IS REALLY RELEVANT

5190
03:07:03,131 --> 03:07:04,032
AND IMPORTANT NOT ONLY TO

5191
03:07:04,032 --> 03:07:06,835
RESEARCH BUT ALSO TO ENGAGE IN

5192
03:07:06,835 --> 03:07:07,469
THE COMMUNITIES.

5193
03:07:07,469 --> 03:07:09,705
SO AGAIN, I THINK WE HAD A

5194
03:07:09,705 --> 03:07:10,639
REALLY ROBUST CONVERSATION

5195
03:07:10,639 --> 03:07:13,041
AROUND THAT, AND THEN FINALLY,

5196
03:07:13,041 --> 03:07:14,476
WE REALLY SAID THAT FOR THE

5197
03:07:14,476 --> 03:07:16,878
SUBCOMMITTEE WE WANT TO START

5198
03:07:16,878 --> 03:07:20,182
IDENTIFYING AREAS THAT THE

5199
03:07:20,182 --> 03:07:21,783
SUBCOMMITTEE CAN ACTUALLY DO A

5200
03:07:21,783 --> 03:07:23,452
LITTLE BIFF OF RESEARCH SO I CAN

5201
03:07:23,452 --> 03:07:26,521
ADVICE, SO IF YOU HAVE IDEAS OR

5202
03:07:26,521 --> 03:07:28,323
THINGS THAT THIS SPECIFIC

5203
03:07:28,323 --> 03:07:30,425
SUBCOMMITTEE CAN ACTUALLY HELP

5204
03:07:30,425 --> 03:07:32,160
TO WORK ON WE HAD SOME GREAT

5205
03:07:32,160 --> 03:07:34,062
IDEAS THAT CAME OUT YESTERDAY,

5206
03:07:34,062 --> 03:07:36,665
BUT I THINK AGAIN IF WE'RE

5207
03:07:36,665 --> 03:07:38,633
THINKING ABOUT EPIDEMIOLOGY,

5208
03:07:38,633 --> 03:07:40,268
POPULATION HEALTH, DISPARITIES,

5209
03:07:40,268 --> 03:07:41,103
OUR DIVERSITY WHAT ARE THE

5210
03:07:41,103 --> 03:07:42,404
THINGS YOU WOULD LIKE TO SEE,

5211
03:07:42,404 --> 03:07:44,039
THIS IS WORK WE WILL DO MORE

5212
03:07:44,039 --> 03:07:46,008
DEEP DIVE OVER THE NEXT COUPLE

5213
03:07:46,008 --> 03:07:47,642
OF WEEKS WITHIN THE SUBCOMMITTEE

5214
03:07:47,642 --> 03:07:49,878
ITSELF, WE WILL BE SENDING OUT A

5215
03:07:49,878 --> 03:07:51,747
SURVEY TO THE MEMBERS BUT THAT

5216
03:07:51,747 --> 03:07:52,981
INCLUDES, WE WANT TO HEAR YOUR

5217
03:07:52,981 --> 03:07:54,249
VOICES AS WELL, AND THEN IN

5218
03:07:54,249 --> 03:07:55,117
SEPTEMBER, WE'RE GOING TO START

5219
03:07:55,117 --> 03:07:57,486
TO GET TO WORK.

5220
03:07:57,486 --> 03:08:00,622
SO WITH THAT I AM HAPPY TO TAKE

5221
03:08:00,622 --> 03:08:03,592
QUESTIONS. 

5222
03:08:03,592 --> 03:08:07,362
NTHANK YOU KAREN. 

5223
03:08:07,362 --> 03:08:17,906
>> WE WILL TART WITH CHUCK
AND

5224
03:08:51,973 --> 03:08:53,041
GO TO ANN--HOSPITALS HAVE AND

5225
03:08:53,041 --> 03:08:54,109
HAVE THAT OPPORTUNITY FOR US TO

5226
03:08:54,109 --> 03:08:56,978
DO WORK THERE AND LASTLY, EARLY

5227
03:08:56,978 --> 03:08:59,948
DETECTION, SO WE TALK ABOUT

5228
03:08:59,948 --> 03:09:01,249
MSTAT BUT I THINK THERE'S

5229
03:09:01,249 --> 03:09:02,617
OPPORTUNITY FOR US TO GROW SO

5230
03:09:02,617 --> 03:09:05,087
FIGURE OUT HOW WE DO BETTER AT

5231
03:09:05,087 --> 03:09:07,089
DETECTING CANCER SAFELY AND

5232
03:09:07,089 --> 03:09:07,989
EFFECTIVELY BECAUSE, MAYBE THE

5233
03:09:07,989 --> 03:09:09,424
LAST THING IS WE LOSE THE STORY

5234
03:09:09,424 --> 03:09:10,392
ON THE SCREENING BECAUSE IF WE

5235
03:09:10,392 --> 03:09:14,029
THINK WE TELL THE STORY AND WE

5236
03:09:14,029 --> 03:09:15,430
NEED IT PERFECTED, MAYBE SCIENCE

5237
03:09:15,430 --> 03:09:16,898
HASN'T DONE A GREAT JOB, WE NEED

5238
03:09:16,898 --> 03:09:19,401
TO DO BETTER AT TELLING THIS

5239
03:09:19,401 --> 03:09:21,736
STORY AT WHAT SCREENING NEEDS.

5240
03:09:21,736 --> 03:09:25,440
>> THANKS TREY.

5241
03:09:25,440 --> 03:09:25,707
NANN?

5242
03:09:25,707 --> 03:09:29,244
>> NOW I BRING UP A STICKY

5243
03:09:29,244 --> 03:09:30,679
SUBJECT, SO THE MSTATS

5244
03:09:30,679 --> 03:09:32,080
ESSENTIALLY WE TALKED ABOUT TIS

5245
03:09:32,080 --> 03:09:33,248
ABLED A COUPLE TIMES.

5246
03:09:33,248 --> 03:09:36,118
>> COULD YOU PULL THE
AMERICA IC

5247
03:09:36,118 --> 03:09:36,351
CLOSER.

5248
03:09:36,351 --> 03:09:42,124
>> I'M USUALLY LOUD
ENOUGH, SO,

5249
03:09:42,124 --> 03:09:44,092
YOU KNOW IESM WOBDERRING THESE

5250
03:09:44,092 --> 03:09:45,460
ARE ALL LAB RAARE TOY TESTS,

5251
03:09:45,460 --> 03:09:47,162
EVERY I THINK ISLE 1 OF THEM SO

5252
03:09:47,162 --> 03:09:50,365
FAR AND THEY'RE MOSTLY IN THE

5253
03:09:50,365 --> 03:09:51,867
PRIVATE SECTOR AND WE ARE NOT

5254
03:09:51,867 --> 03:09:53,969
REGULATING THEM AT ALL, NOW, IN

5255
03:09:53,969 --> 03:09:56,271
THE SENSE THAT THE LEVEL OF

5256
03:09:56,271 --> 03:09:57,772
EVIDENT REQUIRED TO GET THEM

5257
03:09:57,772 --> 03:10:00,942
INTO PATIENTS IS NOT THERE AND I

5258
03:10:00,942 --> 03:10:02,210
DON'T KNOW WHAT WE DO.

5259
03:10:02,210 --> 03:10:06,615
WE DO HAVE AN FDA REP I SEE BACK

5260
03:10:06,615 --> 03:10:07,782
THERE BUT FDA JUST STEPPED

5261
03:10:07,782 --> 03:10:10,152
FORWARD AND SAID WE WILL DO

5262
03:10:10,152 --> 03:10:11,486
SOMETHING ABOUT THIS BUT I WOULD

5263
03:10:11,486 --> 03:10:12,787
ARGUE THAT THE FINANCIAL

5264
03:10:12,787 --> 03:10:15,891
TOXICITY THAT'S GOING TO HIT US,

5265
03:10:15,891 --> 03:10:17,159
BECAUSE THESE ASSAYS ARE OUT

5266
03:10:17,159 --> 03:10:21,229
THERE, THEY'RE BEING SOLD, I

5267
03:10:21,229 --> 03:10:22,297
WEPT TO MRI PHYSICIAN 2 WOKES

5268
03:10:22,297 --> 03:10:25,267
AGO AND THERE IT WAS, I GIVE

5269
03:10:25,267 --> 03:10:27,903
GIVE THEM A THOUSAND DOLLARS AND

5270
03:10:27,903 --> 03:10:29,204
GET MY GALLERIA TEST DONE AND

5271
03:10:29,204 --> 03:10:30,872
I'M NOT SURE WHAT I DO WITH THAT

5272
03:10:30,872 --> 03:10:32,107
DATA, RIGHT?

5273
03:10:32,107 --> 03:10:33,875
SO I MEAN, IS THERE ANYTHING

5274
03:10:33,875 --> 03:10:35,277
THAT WE'VE THOUGHT ABOUT DOING

5275
03:10:35,277 --> 03:10:40,916
MAYBE WITH THE FDA OR HOUR DO WE

5276
03:10:40,916 --> 03:10:43,985
GET THESE TESTS UNDER SOME

5277
03:10:43,985 --> 03:10:45,287
SEMBLANCE OF THE CONTROL SO WE

5278
03:10:45,287 --> 03:10:47,389
GET DATA WE KNOW MEANS SOMETHING

5279
03:10:47,389 --> 03:10:50,592
AND WE CAN START THINK ABOUT

5280
03:10:50,592 --> 03:10:51,560
LIMITING THE FINANCIAL TOXICITY

5281
03:10:51,560 --> 03:10:52,627
THAT WILL DERIVE FROM THIS, IT'S

5282
03:10:52,627 --> 03:10:54,062
GOING TO BE HYG AND YOU KNOW I

5283
03:10:54,062 --> 03:11:01,937
DON'T KNOW IF FDA WANTS TO

5284
03:11:01,937 --> 03:11:02,170
COMMENT?

5285
03:11:02,170 --> 03:11:03,905
NHOW ARE WE GOING TO FIX IT, I

5286
03:11:03,905 --> 03:11:05,340
WANT TO KNOW?

5287
03:11:05,340 --> 03:11:07,375
>> CAN YOU PULL THE
AMERICA IC

5288
03:11:07,375 --> 03:11:07,609
CLOSER.

5289
03:11:07,609 --> 03:11:08,543
>> THIS IS A LITTLE BIT
OUT OF

5290
03:11:08,543 --> 03:11:11,846
MY WHEEL HOUSE BUT I MEAN, THERE

5291
03:11:11,846 --> 03:11:13,582
WAS THIS RECENT LDT RULE THAT

5292
03:11:13,582 --> 03:11:19,654
WAS JUST PASSED AND IIME NOT A

5293
03:11:19,654 --> 03:11:21,623
CDRH REPRESENTATIVEIME WITH THE

5294
03:11:21,623 --> 03:11:23,925
COES SO I'M NOT IN A POSITION TO

5295
03:11:23,925 --> 03:11:27,262
COMMENT AND IT'S AN INTERESTING

5296
03:11:27,262 --> 03:11:30,899
ADVANCEMENT IN THIS AREA WE'RE

5297
03:11:30,899 --> 03:11:31,466
GETTING BETTER, TRAY.

5298
03:11:31,466 --> 03:11:33,301
>> I WAS GOING TO NOT
DELVE INTO

5299
03:11:33,301 --> 03:11:34,769
THIS BUT BECAUSE DR. BARKER DID,

5300
03:11:34,769 --> 03:11:39,074
I WILL CHIME IN, I MEAN I THINK

5301
03:11:39,074 --> 03:11:44,913
THAT OF COURSE NSAID IS VERY

5302
03:11:44,913 --> 03:11:47,916
EXCITING CHALLENGE FOR ME AND

5303
03:11:47,916 --> 03:11:58,426
MARKERS AND THESE ARE NOT AND

5304
03:12:15,477 --> 03:12:17,946
AND I THINK THIS TECHNOLOGY IS

5305
03:12:17,946 --> 03:12:24,986
INVOLVEDDA FROM SINGLE MUTATIONS

5306
03:12:24,986 --> 03:12:26,655
EARLY DETECTION AND WE HAVEN'T

5307
03:12:26,655 --> 03:12:37,132
ACHIEVED PERFORMANCE THAT'S

5308
03:12:37,532 --> 03:12:38,767
REQUIRED, LIKE WE SAID BEFORE WE

5309
03:12:38,767 --> 03:12:40,368
MIGHT BE GETTING TO A POINT

5310
03:12:40,368 --> 03:12:46,775
WHERE WE INTRODUCE MORE

5311
03:12:46,775 --> 03:12:48,176
TOCKISSITY AND WE RECENTLY GET A

5312
03:12:48,176 --> 03:12:50,912
DISCUSSION ABOUT THIS TOPIC, IS

5313
03:12:50,912 --> 03:12:54,783
MSAID READY OR IS THIS

5314
03:12:54,783 --> 03:12:57,152
TECHNOLOGY BETTER SUITED FOR

5315
03:12:57,152 --> 03:12:59,788
TUMOR SC AND SHOULD THAT BE THE

5316
03:12:59,788 --> 03:13:02,223
FIRST STEP FORWARD IT'S A

5317
03:13:02,223 --> 03:13:04,626
DISCUSSION TO HAVE

5318
03:13:04,626 --> 03:13:06,094
ESPECIALENTIALLY BEFORE WORKING.

5319
03:13:06,094 --> 03:13:08,863
NYEAH, VERY CONTROVERSIAL AND

5320
03:13:08,863 --> 03:13:10,799
PROVOCATIVE TOPICS SO WE'RE ON

5321
03:13:10,799 --> 03:13:13,868
THE TOPIC OF CONTROVERSY AND

5322
03:13:13,868 --> 03:13:24,412
STICKY SUBJEKS SO I'VE BEEN AND

5323
03:13:26,047 --> 03:13:27,115
COMPLICATIONS WITHOUT

5324
03:13:27,115 --> 03:13:30,385
NECESSARILY TREATING MEDICAID

5325
03:13:30,385 --> 03:13:31,786
PATIENTS AND SO, DR. WHAT COULD

5326
03:13:31,786 --> 03:13:33,388
BE STUDIED AND I THINK, YOU KNOW

5327
03:13:33,388 --> 03:13:34,889
THIS COULD BE SOMETHING THAT

5328
03:13:34,889 --> 03:13:37,292
COULD BE VERY INTERESTING ACROSS

5329
03:13:37,292 --> 03:13:40,128
THAT SUBMITEE ACROSS THE

5330
03:13:40,128 --> 03:13:46,835
SUBCOMMITTEE FOR CANCER CENTERS

5331
03:13:46,835 --> 03:13:48,703
AND I THINK ABOUT UNDERSTANDING

5332
03:13:48,703 --> 03:13:50,238
THE KINDS OF RESEARCH AND

5333
03:13:50,238 --> 03:13:51,206
ENROLLMENTS THAT ARE ENROLL

5334
03:13:51,206 --> 03:13:57,011
INDEED CANCER CENTERS THAT DO

5335
03:13:57,011 --> 03:13:58,813
AND DON'T AND THEN USING THAT TO

5336
03:13:58,813 --> 03:13:59,881
ADVOCATE, AND WE NEED THE DAILY

5337
03:13:59,881 --> 03:14:01,483
BASIS THEA TO SEE THERE'S A

5338
03:14:01,483 --> 03:14:03,051
DIFFERENCE AND GIVE THE ADVIE WE

5339
03:14:03,051 --> 03:14:13,595
NEED TO WORK ON CHANGING THAT IF

5340
03:14:20,568 --> 03:14:22,203
ACTUALLY ENROLLING PATIENTS, YOU

5341
03:14:22,203 --> 03:14:24,305
KNOW THAT ALSO IS NOT JUST

5342
03:14:24,305 --> 03:14:26,975
DIVERSITY OF RACE BUT ALSO

5343
03:14:26,975 --> 03:14:27,342
POVERTY.

5344
03:14:27,342 --> 03:14:30,712
>> YES, GETTING TO POLICY.

5345
03:14:30,712 --> 03:14:30,945
YEAH.

5346
03:14:30,945 --> 03:14:32,280
>> I THINK POAGHT OF THOSE
ARE A

5347
03:14:32,280 --> 03:14:33,181
GOOD POINT.

5348
03:14:33,181 --> 03:14:35,917
I WILL GO BACK TO NSAIDS JUST

5349
03:14:35,917 --> 03:14:37,619
BRIEFLY BECAUSE MY TEAM RECENTLY

5350
03:14:37,619 --> 03:14:41,189
DID A STUDY OF ADHERENCE TO 1 OF

5351
03:14:41,189 --> 03:14:43,491
THE BLOOD TESTS FOR COLORECTAL

5352
03:14:43,491 --> 03:14:45,293
CANCER AND WE CONDUCTED

5353
03:14:45,293 --> 03:14:45,960
QUALITATIVE INTERVIEWS WITH

5354
03:14:45,960 --> 03:14:47,529
PATIENTS AND I THINK WHAT REALLY

5355
03:14:47,529 --> 03:14:49,831
CONCERNED ME WAS 2 THINGS, 1 IS

5356
03:14:49,831 --> 03:14:51,699
THAT PATIENTS WERE

5357
03:14:51,699 --> 03:14:52,333
OVERWHELMINGLY ENTHUSIASTIC SO

5358
03:14:52,333 --> 03:14:54,702
OUR CODE IS, I WAS SCREEPING

5359
03:14:54,702 --> 03:14:56,337
HALLELUJAH, I WOULD HAVE GIVEN A

5360
03:14:56,337 --> 03:14:58,640
GALLON OF BLOOD TO NOT HAVE TO

5361
03:14:58,640 --> 03:15:03,745
HAVE DONE A COLONOSCOPY, RIGHT?

5362
03:15:03,745 --> 03:15:05,780
HIKE OH NO, AND THE OTHER THING

5363
03:15:05,780 --> 03:15:07,182
THAT PATIENT SAID WELL OF COURSE

5364
03:15:07,182 --> 03:15:08,283
IT'S MORE ACCURATE THAN THE

5365
03:15:08,283 --> 03:15:11,886
OTHER TESTS BECAUSE THIS IS YOUR

5366
03:15:11,886 --> 03:15:12,120
BLOOD.

5367
03:15:12,120 --> 03:15:13,288
AND YOUR BLOOD TELES YOU

5368
03:15:13,288 --> 03:15:13,822
EVERYTHING, RIGHT?

5369
03:15:13,822 --> 03:15:16,224
AND SO EVEN THOUGH WHEN YOU LOOK

5370
03:15:16,224 --> 03:15:17,258
AT THE PERFORMANCE

5371
03:15:17,258 --> 03:15:18,326
CHARACTERISTICS SO FAR WITH SOME

5372
03:15:18,326 --> 03:15:20,094
OF THESE TESTS ARE WAY INFERIOR

5373
03:15:20,094 --> 03:15:22,864
TO THE OTHER MUCH CHEAPER, YOU

5374
03:15:22,864 --> 03:15:23,465
KNOW MORE ACCESSIBLE METHODS

5375
03:15:23,465 --> 03:15:25,900
THAT ARE OUT THERE, AND SO THAT

5376
03:15:25,900 --> 03:15:27,535
CERTAINLY CONCERNED ME AND I DO

5377
03:15:27,535 --> 03:15:29,037
THINK THAT JUST BUILDING ON KIND

5378
03:15:29,037 --> 03:15:30,705
OF THIS IDEA OF WHAT ARE THE

5379
03:15:30,705 --> 03:15:33,274
EXPECTATIONS THAT WE HAVE OF

5380
03:15:33,274 --> 03:15:34,008
COMPREHENSIVE CANCER CENTERS, I

5381
03:15:34,008 --> 03:15:35,510
THINK WE NEED TO THINK ABOUT

5382
03:15:35,510 --> 03:15:37,245
PUTTING OUT PUBLIC STATEMENTS,

5383
03:15:37,245 --> 03:15:41,149
ADVOCATING TO MAKE SURE THAT THE

5384
03:15:41,149 --> 03:15:43,451
HORSE DOESN'T LEAVE THE BARN TOO

5385
03:15:43,451 --> 03:15:44,886
QUICKLY AND WE'RE DEMAND THRG'S

5386
03:15:44,886 --> 03:15:46,054
GOOD PERFORMANCE FOR SOME OF

5387
03:15:46,054 --> 03:15:47,689
THEZ THINGS BEFORE THEY GET OUT

5388
03:15:47,689 --> 03:15:49,557
FOR PUBLIC USE AND THE

5389
03:15:49,557 --> 03:15:53,228
ADVERTISING DOESN'T TAKE OVER. 

5390
03:15:53,228 --> 03:15:53,895
>> LAST COMMENT, RAY?

5391
03:15:53,895 --> 03:15:59,534
>> YOU KNOW I SAID YOUR
NAME

5392
03:15:59,534 --> 03:15:59,901
RIGHT?

5393
03:15:59,901 --> 03:16:00,869
>> SPOORKS SPEAKING OF

5394
03:16:00,869 --> 03:16:04,138
ADVERTISING AND GETTING IN FRONT

5395
03:16:04,138 --> 03:16:05,640
OF EVIDENT, I HOPE EVERYBODY IS

5396
03:16:05,640 --> 03:16:08,943
AWARE THAT THERE'S MANY YEARS

5397
03:16:08,943 --> 03:16:13,848
LONG EFFORT IN DRONG SOMEHOW

5398
03:16:13,848 --> 03:16:15,216
SHOVE THIS MSAID, COMMERCIAL

5399
03:16:15,216 --> 03:16:18,720
NSAID THING FAST TRACK IT WELL

5400
03:16:18,720 --> 03:16:20,588
PAST THE SCIENCE SO OUR

5401
03:16:20,588 --> 03:16:21,623
COLLEAGUES AT NCI, PLEASE BE

5402
03:16:21,623 --> 03:16:22,724
AWARE OF THIS IF YOU'RE NOT

5403
03:16:22,724 --> 03:16:23,892
ALREADY AND A NUMBER OF US

5404
03:16:23,892 --> 03:16:24,826
CONTINUE TO SPEAK TO OUR

5405
03:16:24,826 --> 03:16:27,595
CONGRESS PEOPLE TO SAY, LOOK,

5406
03:16:27,595 --> 03:16:28,796
THIS IS CRAZY, PLEASE PUT THE

5407
03:16:28,796 --> 03:16:32,367
BREAKS ON THIS, BUT, YOU CAN

5408
03:16:32,367 --> 03:16:35,303
TELL THAT THERE'S A VERY WELL

5409
03:16:35,303 --> 03:16:38,106
FUNDED EFFORT THAT IS TRYING TO

5410
03:16:38,106 --> 03:16:39,073
CIRCUMVENT THE PROCESS SO JUST

5411
03:16:39,073 --> 03:16:41,342
BE AWARE OF THAT.

5412
03:16:41,342 --> 03:16:42,010
>> GREAT POINT.

5413
03:16:42,010 --> 03:16:51,653
ALL RIGHT, YOU GET THE LAST

5414
03:16:51,653 --> 03:16:51,920
QUESTION.

5415
03:16:51,920 --> 03:16:52,820
NJUST 1 POINT QUICKLY ABOUT

5416
03:16:52,820 --> 03:16:54,022
THAT, WE WENT OUT AND TALKED

5417
03:16:54,022 --> 03:16:55,523
ABOUT THAT AND WHAT WOULD HELP

5418
03:16:55,523 --> 03:16:58,960
US IS HAVE A CALCULATION OF THE

5419
03:16:58,960 --> 03:17:05,166
FINANCIAL IMPACT IF THESE TESTS

5420
03:17:05,166 --> 03:17:05,900
BECOME RAPIDLY IMPRESSED INTO

5421
03:17:05,900 --> 03:17:07,335
CLINICAL CARE AND I KNOW THERE'S

5422
03:17:07,335 --> 03:17:08,403
FINANCIAL IMPACT FOR THE HELT

5423
03:17:08,403 --> 03:17:09,904
CARE SYSTEM, TO HAVE THOSE

5424
03:17:09,904 --> 03:17:12,073
NUMBERS AT OUR HANDS TO TAKE TO

5425
03:17:12,073 --> 03:17:18,846
OUR CONGRESS PEOPLE AS WE LIKE

5426
03:17:18,846 --> 03:17:20,148
FINANCIAL TOXICITY AND OTHER

5427
03:17:20,148 --> 03:17:21,616
POINTS NTHAT'S AN ANYTHING

5428
03:17:21,616 --> 03:17:23,685
SPOINT, YESTERDAY AT LUNCH ISA

5429
03:17:23,685 --> 03:17:25,987
BELL RAN A CHAT GPT ASKING THAT

5430
03:17:25,987 --> 03:17:27,822
VERY QUESTION AND THE RESULT WAS

5431
03:17:27,822 --> 03:17:28,456
VERY INTERESTING.

5432
03:17:28,456 --> 03:17:29,624
I WON'T ANY INTO THAT BUT IN THE

5433
03:17:29,624 --> 03:17:35,763
INTEREST OF TIME LET'S MOVE ON

5434
03:17:35,763 --> 03:17:37,165
THE NCAB NUMBERS SOME SHOAT TO

5435
03:17:37,165 --> 03:17:38,566
ACCEPT THE REPORT THAT WAS

5436
03:17:38,566 --> 03:17:41,502
PROVIDED BY DR. WING FIELD, IS

5437
03:17:41,502 --> 03:17:43,504
THERE A MOTION?

5438
03:17:43,504 --> 03:17:44,872
SECOND?

5439
03:17:44,872 --> 03:17:46,207
PROPERLY MOVED AND SECOND?

5440
03:17:46,207 --> 03:17:48,076
ANY DISCUSSION IN THERE BEING NO

5441
03:17:48,076 --> 03:17:49,210
1 LET'S VOTE.

5442
03:17:49,210 --> 03:17:55,316
ARE THERE ANY NAYS?

5443
03:17:55,316 --> 03:17:57,118
ANY ABSTENTIONS?

5444
03:17:57,118 --> 03:17:57,385
UNANIMOUS.

5445
03:17:57,385 --> 03:17:58,987
OKAY GREAT SO THE FINAL

5446
03:17:58,987 --> 03:18:00,488
SUBEXITEE REPORT WILL BE BROUGHT

5447
03:18:00,488 --> 03:18:03,625
TO US BY DR. RICHARD BOXER WHO

5448
03:18:03,625 --> 03:18:06,628
THERS THE AD HOC SUBDMITEE ON

5449
03:18:06,628 --> 03:18:07,161
EXPERIMENTAL THERAPEUTICS,

5450
03:18:07,161 --> 03:18:07,395
RICHARD.

5451
03:18:07,395 --> 03:18:13,668
NTHANK YOU VERY MUCH.

5452
03:18:13,668 --> 03:18:15,970
AS A DEMONITRATION OF ENTHUSIASM

5453
03:18:15,970 --> 03:18:17,472
AND ENGAGEMENT OF OUR

5454
03:18:17,472 --> 03:18:18,473
SUBCOMMITTEE IT MET BETWEEN 8

5455
03:18:18,473 --> 03:18:19,974
AND 9 OOH CLOCK AND EVERYONE WAS

5456
03:18:19,974 --> 03:18:28,916
STILL AWAKE AT THE END.

5457
03:18:28,916 --> 03:18:30,752
WELL, MAYBE NOT EVERYONE BUT

5458
03:18:30,752 --> 03:18:32,053
PEOPLE DID STICK AROUND TILL THE

5459
03:18:32,053 --> 03:18:32,286
END.

5460
03:18:32,286 --> 03:18:37,158
I WANTED TO SAY A COUPLE THIJS,

5461
03:18:37,158 --> 03:18:41,062
FIRST OF ALL, DR. OROJAMA HAS

5462
03:18:41,062 --> 03:18:41,996
BEEN INCREDIBLY SUPPORTIVE AND

5463
03:18:41,996 --> 03:18:43,865
HELPFUL AND DR. GRAY HAS BEEN

5464
03:18:43,865 --> 03:18:45,633
KEEPING US IN THE GUARD RAILS

5465
03:18:45,633 --> 03:18:51,039
AND BEEN VERY, VERY HELPFUL FOR

5466
03:18:51,039 --> 03:18:53,107
THE SUBCOMMITTEE BECAUSE THE

5467
03:18:53,107 --> 03:18:54,275
SUBCOMMITTEE ORIGINALLY CAME

5468
03:18:54,275 --> 03:18:55,777
INTO BEING ABOUT 20 YEARS AGO

5469
03:18:55,777 --> 03:18:58,346
AND THEN QUICKLY WENT TO SLEEP

5470
03:18:58,346 --> 03:18:59,814
SPEAKING ABOUT 8 OH CLOCK OR 9

5471
03:18:59,814 --> 03:19:02,250
ARK CLOCK WENT TO ASLEEP FOR

5472
03:19:02,250 --> 03:19:03,418
ABOUT 10 OR 15 YEARS AND NOTHING

5473
03:19:03,418 --> 03:19:06,988
WAS DONE AND WHEN I WAS ASKED

5474
03:19:06,988 --> 03:19:08,923
INEXPLICABLY IN MY MIND TO LEAD

5475
03:19:08,923 --> 03:19:12,026
IT, I WENT BACK AND LOOKEDDA THE

5476
03:19:12,026 --> 03:19:13,995
VISUAL OR THE MISSION STATEMENT,

5477
03:19:13,995 --> 03:19:17,899
NOW THIS IS FOR EXPERIMENTAL

5478
03:19:17,899 --> 03:19:19,067
THERAPEUTICS AND NOTHING HAD

5479
03:19:19,067 --> 03:19:20,134
BEEN DONE FOR 20 YEARS, AND SO

5480
03:19:20,134 --> 03:19:23,204
WITH THE HELP OF THE SUBMITEE

5481
03:19:23,204 --> 03:19:32,814
AND WE WERE VERY PLEASED THAT

5482
03:19:32,814 --> 03:19:33,748
DR. CARPTEN AND WERE ALL

5483
03:19:33,748 --> 03:19:35,583
SUPPORTIVE OF THE COMMITTEE

5484
03:19:35,583 --> 03:19:37,151
THERE, WE DECIDED AS A

5485
03:19:37,151 --> 03:19:38,619
SUBCOMMITTEE EARLY ON THAT WE

5486
03:19:38,619 --> 03:19:42,557
WERE GOING TO CREATE A NEW

5487
03:19:42,557 --> 03:19:43,491
MISSION STATEMENT BECAUSE AFTER

5488
03:19:43,491 --> 03:19:44,792
ALL IT'S BEEN A LONG TIME AND

5489
03:19:44,792 --> 03:19:46,194
WE'RE SUPPOSED TO BE

5490
03:19:46,194 --> 03:19:47,261
EXPERIMENTAL LOOKING AT THE

5491
03:19:47,261 --> 03:19:50,698
HORIZON AND SO AS A GOAL, FOR ME

5492
03:19:50,698 --> 03:19:52,333
AND FOR THE SUBCOMMITTEE WAS TO

5493
03:19:52,333 --> 03:19:53,601
CREATE A NEW MISSION STATEMENT

5494
03:19:53,601 --> 03:19:58,873
WHICH IS IN YOUR FOLDERS, AND

5495
03:19:58,873 --> 03:20:01,075
WE--IT TOOK 15 OR SO ITERATIONS

5496
03:20:01,075 --> 03:20:04,445
OVER THE PAST 6 MONTHS BUT WE

5497
03:20:04,445 --> 03:20:10,485
FINALLY BROUGHT SOMETHING

5498
03:20:10,485 --> 03:20:11,886
TOGETHER THAT WOULD INCLUDE--WAS

5499
03:20:11,886 --> 03:20:13,187
BROUGHT ENOUGH TO HAVE AN

5500
03:20:13,187 --> 03:20:14,722
UMBRELLA FOR ANYTHING WE WOULD

5501
03:20:14,722 --> 03:20:16,824
BE INTERESTED IN AS GROUP, AS AN

5502
03:20:16,824 --> 03:20:19,761
NCAB TO LOOK AT BUT HAVE SOME

5503
03:20:19,761 --> 03:20:23,664
SPECIFIC IDEAS IN ORDER TO

5504
03:20:23,664 --> 03:20:24,565
DEVELOP ACTIONABLE ITEMS SO

5505
03:20:24,565 --> 03:20:25,500
WITHIN THAT MISSION STATEMENT,

5506
03:20:25,500 --> 03:20:27,969
WE HOPE THAT WE WERE ABLE TO

5507
03:20:27,969 --> 03:20:29,871
INCLUDE EVERYTHING, ALTHOUGH I

5508
03:20:29,871 --> 03:20:33,207
MUST SAY THAT DR. LOPEZ ADDED

5509
03:20:33,207 --> 03:20:34,008
COMMUNITIES WHICH WAS REALLY

5510
03:20:34,008 --> 03:20:35,743
IMPORTANT AND THOSE WORDS

5511
03:20:35,743 --> 03:20:37,044
RESEARCH ADDED INTO THE MISSION

5512
03:20:37,044 --> 03:20:38,713
STATEMENT.

5513
03:20:38,713 --> 03:20:40,815
IN ADDITION TO THE CREATION OF A

5514
03:20:40,815 --> 03:20:43,117
NEW MISSION STATEMENT, WE ALSO

5515
03:20:43,117 --> 03:20:53,628
DECIDED THAT, IT WOULD BE VERY

5516
03:20:58,032 --> 03:20:59,333
IMPORTANT TO UTILIZE, THE

5517
03:20:59,333 --> 03:21:01,102
KNOWLEDGE OF THE NCAB MEMBERS

5518
03:21:01,102 --> 03:21:03,070
AND INCLUDING AND SPECIFICALLY

5519
03:21:03,070 --> 03:21:04,939
THE SUBCOMMITTEE MEMBERS BUT THE

5520
03:21:04,939 --> 03:21:08,009
NCAB AS A WHOLE TO BE ABLE TO

5521
03:21:08,009 --> 03:21:10,778
USE THE TALENT THAT THE NCAB HAS

5522
03:21:10,778 --> 03:21:14,949
WITHIN IT AND TO AMRI THAT TO

5523
03:21:14,949 --> 03:21:15,583
THE EXPERIMENTAL THERAPEUTICS

5524
03:21:15,583 --> 03:21:20,655
AND O WITH THAT IN MIND, WE

5525
03:21:20,655 --> 03:21:22,824
BELIEVE IN--WE'VE GOTTEN

5526
03:21:22,824 --> 03:21:23,891
DR. RATHMILL HAS BEEN KIND

5527
03:21:23,891 --> 03:21:24,725
ENOUGH TO SUPPORT THIS, WE ARE

5528
03:21:24,725 --> 03:21:30,364
ANYTHING TO HAVE A CONFERENCE,

5529
03:21:30,364 --> 03:21:31,632
SUMMIT, WORKSHOP, WHATEVER WE

5530
03:21:31,632 --> 03:21:33,067
WILL ULTIMATELY CALL IT, IT WILL

5531
03:21:33,067 --> 03:21:34,602
BE BRINGING THE RELEVANT

5532
03:21:34,602 --> 03:21:38,139
PARTNERS AND ACADEMIA, THE NCAB,

5533
03:21:38,139 --> 03:21:42,210
AND THE NCI, PRIVATE SECTOR TO

5534
03:21:42,210 --> 03:21:45,112
TALK ABOUT AND DEVISE 3, PERHAPS

5535
03:21:45,112 --> 03:21:47,782
3, BECAUSE WE HAVE TO BE

5536
03:21:47,782 --> 03:21:48,482
SOMEWHAT LIMITED ACTIONABLE

5537
03:21:48,482 --> 03:21:51,385
ITEMS FOR THE FUTURE OF

5538
03:21:51,385 --> 03:22:00,561
THERAPEUTICS IN FOR THE PATIENT.

5539
03:22:00,561 --> 03:22:06,968
AND THE PATIENTS CARES ABOUT

5540
03:22:06,968 --> 03:22:07,568
THERAPEUTICS, DIAGNOSTICS AND

5541
03:22:07,568 --> 03:22:08,536
ULTIMATELY THIS IS WHAT WE'RE

5542
03:22:08,536 --> 03:22:09,503
ALL ABOUT, TO HELP THE PATIENT

5543
03:22:09,503 --> 03:22:12,273
AND SO WITH THAT IN MIND, WE'RE

5544
03:22:12,273 --> 03:22:13,341
GOING TO--WE PROPOSE NOT ONLY

5545
03:22:13,341 --> 03:22:15,343
THE MISSION STATEMENT BUT ALSO

5546
03:22:15,343 --> 03:22:16,377
TO HAVE--TO CONVENE A

5547
03:22:16,377 --> 03:22:20,648
CONPRESENCE WHICH WILL PROBABLY

5548
03:22:20,648 --> 03:22:21,716
BE OCTOBER MAYBE WITH THE HELP

5549
03:22:21,716 --> 03:22:23,985
OF ALL THE STAFF THAT IS

5550
03:22:23,985 --> 03:22:25,887
NECESSARY AND SOME OF US WILL BE

5551
03:22:25,887 --> 03:22:27,955
MORE INVOLVED THAN OTHERS, BUT

5552
03:22:27,955 --> 03:22:29,790
WE'RE SURE GLAD TO HAVE STAFF,

5553
03:22:29,790 --> 03:22:31,659
AND IN ANY CASE, IT'S--I THINK

5554
03:22:31,659 --> 03:22:33,294
THAT THAT WILL BE VERY VALUABLE

5555
03:22:33,294 --> 03:22:37,865
FOR ALL OF US IN PARTICULARLY

5556
03:22:37,865 --> 03:22:45,006
FOR THE PATIENTS.

5557
03:22:45,006 --> 03:22:46,841
WE TALKED ABOUT THE CONCURRENCE

5558
03:22:46,841 --> 03:22:48,576
OF THE TBRAIT MISSION STATEMENT

5559
03:22:48,576 --> 03:22:49,543
AND RECEIVED GREAT INPUT FROM

5560
03:22:49,543 --> 03:22:50,745
THE MEMBERS AND WE TALKED ABOUT

5561
03:22:50,745 --> 03:22:54,181
THE FOCUS AREAS OF FUTURE

5562
03:22:54,181 --> 03:22:57,118
AGENDA, AND GOT WONDERFUL

5563
03:22:57,118 --> 03:23:01,956
COMMENTS FROM DRS. LOPEZ,

5564
03:23:01,956 --> 03:23:03,424
CARPTEN, [INDISCERNIBLE] AND

5565
03:23:03,424 --> 03:23:04,592
BARKER AND SO WITH ALL THE

5566
03:23:04,592 --> 03:23:08,663
INFORMATION THAT WE'RE ABLE TO

5567
03:23:08,663 --> 03:23:10,398
BRING TO THE SUBCOMMITTEE AND

5568
03:23:10,398 --> 03:23:12,199
NOW WE'RE BRINGING IT TO THE

5569
03:23:12,199 --> 03:23:13,935
NCAB, WE'RE HOPEFUL THAT THE

5570
03:23:13,935 --> 03:23:17,872
NCAB WILL VOTE ON AND ACCEPT OUR

5571
03:23:17,872 --> 03:23:19,941
MISSION STATEMENT AS WELL AS THE

5572
03:23:19,941 --> 03:23:23,210
IDEA OF HAVING A CONFERENCE TO

5573
03:23:23,210 --> 03:23:27,081
BRING TOGETHER ALL THE

5574
03:23:27,081 --> 03:23:33,087
STAKEHOLDERS, RELEVANT PEOPLE

5575
03:23:33,087 --> 03:23:34,188
AND HAVE THE WHICH SOME PEOPLE

5576
03:23:34,188 --> 03:23:36,290
MIGHT BE THE BEATING HEART AND

5577
03:23:36,290 --> 03:23:40,928
THE SOUL OF THE NCI FOR THE

5578
03:23:40,928 --> 03:23:43,864
SUPER INCREDIBLE POTENTIAL

5579
03:23:43,864 --> 03:23:45,499
THERAPEUTICS THAT WILL COME TO

5580
03:23:45,499 --> 03:23:54,208
THE PATIENT.

5581
03:23:54,208 --> 03:23:55,576
THANK YOU.

5582
03:23:55,576 --> 03:23:57,678
>> THANKS RICHARD.

5583
03:23:57,678 --> 03:24:03,517
QUESTIONS DR. BOXER? 

5584
03:24:03,517 --> 03:24:04,018
COMMENTS?

5585
03:24:04,018 --> 03:24:04,318
>> JULIE?

5586
03:24:04,318 --> 03:24:05,953
>> I WILL LIKE TO SAY
THANK TO

5587
03:24:05,953 --> 03:24:07,822
YOU OUR OMAZING CHAIR AND TO

5588
03:24:07,822 --> 03:24:11,025
ROSE FOR HER LEADERSHIP.

5589
03:24:11,025 --> 03:24:16,263
WE WILL LOVE FOR YOU GUYS TO

5590
03:24:16,263 --> 03:24:17,631
SHOW UP THIS MEETING, IT IS A

5591
03:24:17,631 --> 03:24:18,632
LOT OF FUN.

5592
03:24:18,632 --> 03:24:19,900
THIS IS THINKING MORE OF A

5593
03:24:19,900 --> 03:24:21,802
COMMENT WHICH IS PART OF WHAT

5594
03:24:21,802 --> 03:24:23,270
OUR ARK MAZING LEADERS HERE AT

5595
03:24:23,270 --> 03:24:25,106
THE NCI NEED TO DO IS INSPIRE

5596
03:24:25,106 --> 03:24:28,075
CONGRESS TO FUND US, AND THE

5597
03:24:28,075 --> 03:24:30,211
INSPIRATION OF HOW WE CAN BRING

5598
03:24:30,211 --> 03:24:31,846
NEW TREATMENTS TO PATIENTS OFTEN

5599
03:24:31,846 --> 03:24:32,880
IS THROUGH THE INCREDIBLE DATA

5600
03:24:32,880 --> 03:24:36,183
WE GET TO SEE AT ASCO AND OTHER

5601
03:24:36,183 --> 03:24:37,818
CONFERENCES WHERE WE SEE A MASS

5602
03:24:37,818 --> 03:24:39,320
INSIDE A HUMAN'S BRAIN AND THEN

5603
03:24:39,320 --> 03:24:43,657
IT DISAPPEARS AND SO, I THINK

5604
03:24:43,657 --> 03:24:46,627
THAT FINDING A WAY TO ENGAGE

5605
03:24:46,627 --> 03:24:48,262
AROUND EXPERIMENTAL THERAPEUTICS

5606
03:24:48,262 --> 03:24:50,097
AND ALSO EMBRACING TECHNOLOGY SO

5607
03:24:50,097 --> 03:24:51,932
WE CAN COMPLETE THESE TRIAL

5608
03:24:51,932 --> 03:24:53,667
NOSTHE COMMUNITY AND SCALE OUR

5609
03:24:53,667 --> 03:24:54,602
WORKFORCE WILL BE REALLY

5610
03:24:54,602 --> 03:24:56,303
IMPORTANT TO UNDERSTAND FROM A

5611
03:24:56,303 --> 03:24:57,304
MULTIPASQUANTINO AT THE TIMED

5612
03:24:57,304 --> 03:25:00,174
PERSPECTIVE AND AS A MEMBER

5613
03:25:00,174 --> 03:25:01,308
REPRESENTING SMALL BIOTECH THIS

5614
03:25:01,308 --> 03:25:02,376
WILL BE AN IMPORTANT

5615
03:25:02,376 --> 03:25:02,977
CONVERSATION ACROSS STEAK

5616
03:25:02,977 --> 03:25:04,111
HOLDERS TO HAVE YOU PARTICIPATE

5617
03:25:04,111 --> 03:25:05,780
IN AND I WANT TO SAY THANK TO

5618
03:25:05,780 --> 03:25:08,049
YOU THE NCI FOR RESURRECTING

5619
03:25:08,049 --> 03:25:08,482
THIS COMMIT EYE.

5620
03:25:08,482 --> 03:25:11,786
IT IS FANTASTIC AND I THINK THAT

5621
03:25:11,786 --> 03:25:19,693
WE WILL DO GREAT THINGS TOGETHER

5622
03:25:19,693 --> 03:25:21,562
FOR PATIENTS.

5623
03:25:21,562 --> 03:25:21,862
NQUESTIONS?

5624
03:25:21,862 --> 03:25:22,530
>> GREAT PRESENTATION AND

5625
03:25:22,530 --> 03:25:29,770
EXCITING WHAT WILL BE THE OUT

5626
03:25:29,770 --> 03:25:32,106
PUT OF THE MEETING IN THE

5627
03:25:32,106 --> 03:25:32,406
CONFERENCE?

5628
03:25:32,406 --> 03:25:35,109
>> WELL THE CONFERENCE WE
HOPE

5629
03:25:35,109 --> 03:25:38,512
WILL BRING TOGETHER THE MINDS

5630
03:25:38,512 --> 03:25:40,247
AND ENTHUSIASM OF THE VARIOUS

5631
03:25:40,247 --> 03:25:44,218
STAKEHOLDERS TO FIND THERE MAY

5632
03:25:44,218 --> 03:25:45,719
BE 12, MAYBE 15 DIFFERENT AREAS

5633
03:25:45,719 --> 03:25:49,690
THAT WILL BE EXTRAORDINARILY

5634
03:25:49,690 --> 03:25:51,092
IMPORTANT FOR THE THERAPEUTICS

5635
03:25:51,092 --> 03:25:52,593
FOR THE EXPERIMENTAL

5636
03:25:52,593 --> 03:25:54,195
THERAPEUTICS BUT WE HAVE TO PAIR

5637
03:25:54,195 --> 03:25:59,533
THAT DOWN TO MAYBE 3 AND SAY,

5638
03:25:59,533 --> 03:26:01,368
OKAY FINE, AND IN THE NEXT 3

5639
03:26:01,368 --> 03:26:03,537
YEARS WE WILL ACCOMPLISH ALL 12

5640
03:26:03,537 --> 03:26:06,107
BUT IN THE FIRST YEAR OR 2 WE

5641
03:26:06,107 --> 03:26:07,374
HAVE TO DO 3 ONLY BECAUSE WE

5642
03:26:07,374 --> 03:26:09,143
WANT HAVE THE WILL, WE JUST MAY

5643
03:26:09,143 --> 03:26:11,812
NOT HAVE THE WAY BECAUSE THERE'S

5644
03:26:11,812 --> 03:26:13,781
JUST NOT ENOUGH MONEY, BUT AT

5645
03:26:13,781 --> 03:26:15,649
LEAST WE'LL HAVE SOME OF KIND OF

5646
03:26:15,649 --> 03:26:19,453
A PATHWAY TO IMPROVING THE

5647
03:26:19,453 --> 03:26:21,255
THERAPEUTICS AND FOR THE PATIENT

5648
03:26:21,255 --> 03:26:26,026
AND THAT UNTO ITSELF WILL BE

5649
03:26:26,026 --> 03:26:26,994
INSPIRING HOPE FOR THE

5650
03:26:26,994 --> 03:26:28,262
POPULATION FOR AMERICAN ANDS FOR

5651
03:26:28,262 --> 03:26:35,936
WORLD WIDE AS FAR AS IT GOES

5652
03:26:35,936 --> 03:26:38,405
TOWARDS CANCER CARE.

5653
03:26:38,405 --> 03:26:40,007
>> I GUESS CLARIFICATION
FROM

5654
03:26:40,007 --> 03:26:43,677
ME, SO THE COMMITTEE IS GOING TO

5655
03:26:43,677 --> 03:26:47,648
CONVENE, CREATE A REPORT, SO

5656
03:26:47,648 --> 03:26:51,318
ADVISE N NCI, SO THE COMMITTEE S

5657
03:26:51,318 --> 03:26:54,922
TO THE 1 DOING THE WORK ON

5658
03:26:54,922 --> 03:26:55,990
PRPLTAL THERAPEUTICS, RIGHT?

5659
03:26:55,990 --> 03:26:58,459
>> THAT'S CORRECT.

5660
03:26:58,459 --> 03:27:02,062
WE ARE AN ADVISORY COMMITTEE,

5661
03:27:02,062 --> 03:27:05,666
ANAD HOC ADVISORY COMMITTEE TO

5662
03:27:05,666 --> 03:27:07,301
DR. RATHMILL AND THE NCI AND HOW

5663
03:27:07,301 --> 03:27:08,836
ULTIMATELY IT IS USED TO WILL BE

5664
03:27:08,836 --> 03:27:13,741
UP TO THE NCI, NOT UP TO US BUT

5665
03:27:13,741 --> 03:27:18,612
WE WANT TO INSPIRE HOPE AND

5666
03:27:18,612 --> 03:27:19,680
ENTHUSIASM WITHIN ALL THE

5667
03:27:19,680 --> 03:27:21,515
COMMUNITY, ALL THE STAKEHOLDERS,

5668
03:27:21,515 --> 03:27:26,854
SO THAT WE'RE ALL WORKING

5669
03:27:26,854 --> 03:27:27,254
TOGETHER.

5670
03:27:27,254 --> 03:27:29,523
NTHANKS SO MUCH, I WANT TO ECHO

5671
03:27:29,523 --> 03:27:31,959
ON YULEY'S COMMENTS AND

5672
03:27:31,959 --> 03:27:34,295
DR. BOXER'S COMMENTS TO INSPIRE

5673
03:27:34,295 --> 03:27:35,329
ENTHUSIASM AND ENERGY AND

5674
03:27:35,329 --> 03:27:38,566
MOMENTUM PARTICULARLY FOR OUR

5675
03:27:38,566 --> 03:27:39,900
MEMBERS OF CONGRESS AS WELL

5676
03:27:39,900 --> 03:27:41,035
GIVEN THE STRUCTURAL ISSUES WE

5677
03:27:41,035 --> 03:27:42,469
HEARD ABOUT THIS MORNING, SO I

5678
03:27:42,469 --> 03:27:43,771
THINK THERE WILL BE A DPRAIT

5679
03:27:43,771 --> 03:27:45,739
OPPORTUNITY FOR THIS MEETING TO

5680
03:27:45,739 --> 03:27:46,440
INCLUDE PATIENT ADVOCATES AS

5681
03:27:46,440 --> 03:27:49,009
WELL AS THE BROADER CANCER

5682
03:27:49,009 --> 03:27:50,477
ADVOCACY COMMUNITY IN GENERAL,

5683
03:27:50,477 --> 03:27:52,246
SO THAT THEY ARE FULLY BRIEFED

5684
03:27:52,246 --> 03:27:54,348
ON WHERE NETWORK CI EXPERIMENTAL

5685
03:27:54,348 --> 03:27:55,082
THERAPEUTICS IS TODAY, WHERE IT

5686
03:27:55,082 --> 03:27:58,385
BEING BE IN THE FUTURE AND WHAT

5687
03:27:58,385 --> 03:27:59,787
NEEDS TO HAPPEN PER THAT FUTURE

5688
03:27:59,787 --> 03:28:01,622
TO OCCUR BECAUSE WE WOULD NEED

5689
03:28:01,622 --> 03:28:03,257
SOMETHING VERY DIFFERENT IF WE

5690
03:28:03,257 --> 03:28:07,061
WANT A REALLY EXCITING FUTURE

5691
03:28:07,061 --> 03:28:09,096
FOR EXPERIMENTAL THERAPEUTICS.

5692
03:28:09,096 --> 03:28:10,631
NETWORK AS IT APPLIES TO THE

5693
03:28:10,631 --> 03:28:12,266
CONGRESS, WE'VE BEEN TOLD

5694
03:28:12,266 --> 03:28:16,737
REPEATEDLY BY DR. GRAY THAT WE

5695
03:28:16,737 --> 03:28:20,040
AS NCAB MEMBERS CANNOT LOBBY

5696
03:28:20,040 --> 03:28:22,910
CONGRESS AND SO, WITH THAT IN

5697
03:28:22,910 --> 03:28:24,445
MIND, WE CAN HAVE PATIENT

5698
03:28:24,445 --> 03:28:27,281
ADVOCATES DO THAT FOR US SO I

5699
03:28:27,281 --> 03:28:30,184
THINK THAT WOULD BE--IT'S A VERY

5700
03:28:30,184 --> 03:28:31,952
GOOD IDEA.

5701
03:28:31,952 --> 03:28:35,422
WE WILL HAVE THEM MARCH--I

5702
03:28:35,422 --> 03:28:37,258
PERSONALLY WENT BUYER I WAS ON

5703
03:28:37,258 --> 03:28:39,226
THE NCAB OR IN BETWEEN

5704
03:28:39,226 --> 03:28:43,397
DIFFERENT--I WAS IN ON THE NCAB,

5705
03:28:43,397 --> 03:28:45,733
I WENT TO CONGRESS FOR A

5706
03:28:45,733 --> 03:28:46,667
LYMPHOMA AND LEUKEMIA GROUP AND

5707
03:28:46,667 --> 03:28:49,603
IT WAS CALLED THE OUTER ROOM WAS

5708
03:28:49,603 --> 03:28:52,506
CALLED MOTHER TERESTIMATE THAD'S

5709
03:28:52,506 --> 03:28:53,540
WAITING ROOM BECAUSE EVERYONE

5710
03:28:53,540 --> 03:28:57,444
WAS ANYTHING INTO THE CONGRESS

5711
03:28:57,444 --> 03:28:59,113
BEGGING FOR MONEY.

5712
03:28:59,113 --> 03:29:02,549
AND IT WAS MA EFFECTIVE, QUITE

5713
03:29:02,549 --> 03:29:04,218
EFFECTIVE, ACTUALLY, BUT ONCE

5714
03:29:04,218 --> 03:29:06,620
AGAIN, IT'S ADVOCACY GROUPS THAT

5715
03:29:06,620 --> 03:29:12,159
CAN ADVOCATE THE NCAB CAN JUST

5716
03:29:12,159 --> 03:29:12,960
EDUCATE.

5717
03:29:12,960 --> 03:29:13,661
>> GREAT.

5718
03:29:13,661 --> 03:29:15,863
THANKS DR. BOXER, GREAT

5719
03:29:15,863 --> 03:29:17,464
DISCUSSION, SO NCAB MEMBERS,

5720
03:29:17,464 --> 03:29:19,867
SHOULD VOTE TO ACCEPT THE

5721
03:29:19,867 --> 03:29:20,100
REPORT.

5722
03:29:20,100 --> 03:29:30,411
IS THERE A MOTION?

5723
03:29:34,882 --> 03:29:37,184
>> I HAVE A BIT OF A
CONCERN

5724
03:29:37,184 --> 03:29:39,153
RAISED EARLIER IT WAS MAKING ME

5725
03:29:39,153 --> 03:29:42,623
EAT ABOUT THE MCEDs AND NOW

5726
03:29:42,623 --> 03:29:43,223
AND HOW ENTHUSIASTICALLY THE

5727
03:29:43,223 --> 03:29:43,891
APPROXIMATE UBIQUITINNATION LICK

5728
03:29:43,891 --> 03:29:45,693
IS PICKING UP ON THIS, I KNOW

5729
03:29:45,693 --> 03:29:47,328
FOR A FACT THAT IN CALIFORNIA

5730
03:29:47,328 --> 03:29:57,871
THERE WAS A WHOLE CONSORTIUM OF

5731
03:29:58,472 --> 03:30:01,008
FOLK WHO WERE MOVING TO WRITE

5732
03:30:01,008 --> 03:30:03,344
LETTERS TO CONGRESS, AND I HAVE

5733
03:30:03,344 --> 03:30:06,447
NEW DATA THAT ADVOCACY LETTER VS

5734
03:30:06,447 --> 03:30:09,850
SIGNED GROUPS WRITING LETTERS TO

5735
03:30:09,850 --> 03:30:10,951
CONGRESS PUSHING MCED COVERED

5736
03:30:10,951 --> 03:30:12,252
THROUGH MEDICARE SO WHAT I AM

5737
03:30:12,252 --> 03:30:19,960
THINKING IS THE COMMUNITIES NEED

5738
03:30:19,960 --> 03:30:21,562
TO BE EDUCATED BECAUSE CERTAINLY

5739
03:30:21,562 --> 03:30:22,396
THEY WANT EXPERIMENTAL DRUGS

5740
03:30:22,396 --> 03:30:24,665
THAT WILL MAKE A DIFFERENCE IN

5741
03:30:24,665 --> 03:30:26,667
THEIR LOVE 1S LIVES BUT IF WE'RE

5742
03:30:26,667 --> 03:30:28,669
MOVING TOO FAST FOR CAPITALISM

5743
03:30:28,669 --> 03:30:29,403
IS MOVING FASTER THAN THE

5744
03:30:29,403 --> 03:30:33,374
SCIENCE, AND THERE ARE PEOPLE

5745
03:30:33,374 --> 03:30:35,509
WHO REALLY WANT TO MAKE A DOLLAR

5746
03:30:35,509 --> 03:30:37,344
AS OPPOSED TO CONCERNED ABOUT

5747
03:30:37,344 --> 03:30:38,445
THE SAFETY AND WELFARE OF

5748
03:30:38,445 --> 03:30:40,147
PATIENTS OR EVEN THE

5749
03:30:40,147 --> 03:30:40,814
DISAPPOINTMENT OF PATIENT WHO IS

5750
03:30:40,814 --> 03:30:42,983
WILL NOT GET THE RIGHT KINDS OF

5751
03:30:42,983 --> 03:30:45,085
DIAGNOSIS AS A RESULT OF THESE

5752
03:30:45,085 --> 03:30:46,620
TESTS OR THE WRONG DIAGNOSIS OR

5753
03:30:46,620 --> 03:30:48,722
LED DOWN THE WRONG PATH SO I'M

5754
03:30:48,722 --> 03:30:51,725
SIMPLY SAYING THAT WE NEED

5755
03:30:51,725 --> 03:30:54,228
SOMEHOW AS NCI TO CREATE SOME

5756
03:30:54,228 --> 03:30:56,964
KINDS OF EDUCATIONAL TOOL KITS

5757
03:30:56,964 --> 03:30:58,932
AROUND THESE TO GET BACK INTO

5758
03:30:58,932 --> 03:31:00,501
THE HANDS OF THESE COMMUNITY

5759
03:31:00,501 --> 03:31:01,869
GROUPS SO THEY'RE NOT JUST, WOW,

5760
03:31:01,869 --> 03:31:03,404
THIS IS GREAT, WELL THE'S GO GET

5761
03:31:03,404 --> 03:31:05,038
THIS, AND THEY'RE JUMPING ON

5762
03:31:05,038 --> 03:31:08,308
THESE BAND WAGONS BECAUSE THEY

5763
03:31:08,308 --> 03:31:09,276
THINK THAT IT'S CRITICAL AND

5764
03:31:09,276 --> 03:31:11,445
THEY WANT TO GO TO CONGRESS AND

5765
03:31:11,445 --> 03:31:21,989
LOBBY FOR THE DOLLARS TO DO THIS

5766
03:31:24,358 --> 03:31:25,926
AND WHEN THIS FACT IT WILL NOT

5767
03:31:25,926 --> 03:31:27,661
BE GOOD FOR THE COMMENTS AND THE

5768
03:31:27,661 --> 03:31:28,362
PATIENTS I'VE ALWAYS BEEN

5769
03:31:28,362 --> 03:31:29,797
CONCERNED FOR THE PATIENT AND WE

5770
03:31:29,797 --> 03:31:31,398
NEED TO LEND A HAND AND REACH

5771
03:31:31,398 --> 03:31:33,233
BACK OUT INTO THE COMMUNITIES

5772
03:31:33,233 --> 03:31:34,435
AND PATIENT ADVOCATE GROUPS TO

5773
03:31:34,435 --> 03:31:37,638
PROVIDE THEM WITH A SLOW DOWN.

5774
03:31:37,638 --> 03:31:40,707
NJUST 1 LAST, I THINK THAT WE

5775
03:31:40,707 --> 03:31:41,875
CAN WALK AND CHEW GUM AT THE

5776
03:31:41,875 --> 03:31:42,576
SAME TIME.

5777
03:31:42,576 --> 03:31:47,681
THAT IS WE CAN FORCE OR IMPROVE

5778
03:31:47,681 --> 03:31:51,752
THERAPEUTICS AND THEN I'VE BEEN

5779
03:31:51,752 --> 03:31:54,521
PASSIONATE ABOUT GETTING ACCESS

5780
03:31:54,521 --> 03:31:55,889
FOR ALL PATIENTS WITHIN THE

5781
03:31:55,889 --> 03:31:57,724
UNITED STATES OR AROUND THE

5782
03:31:57,724 --> 03:32:02,396
WORLD FOR THE EXCITING POTENTIAL

5783
03:32:02,396 --> 03:32:03,864
THERAPEUTICS DIAGNOSTICS, ET

5784
03:32:03,864 --> 03:32:05,799
CETERA, THE ACCESS TO CARE AND

5785
03:32:05,799 --> 03:32:07,201
TERRIBLE AND THAT'S SOMETHING

5786
03:32:07,201 --> 03:32:10,637
THAT I ACTUALLY THINK, YOU KNOW

5787
03:32:10,637 --> 03:32:12,272
IS TERRIBLY CRUEL IN THAT WE CAN

5788
03:32:12,272 --> 03:32:13,240
MAKE AN ANNOUNCEMENT THAT

5789
03:32:13,240 --> 03:32:15,676
THERE'S A CURE, THERE'S A

5790
03:32:15,676 --> 03:32:16,510
THERAPEUTICS OR WHATEVER, BUT

5791
03:32:16,510 --> 03:32:17,711
YOU CAN'T GET IT.

5792
03:32:17,711 --> 03:32:19,847
I MEAN THAT'S REALLY ADDING

5793
03:32:19,847 --> 03:32:21,348
INSULT TO YOUR AND IT'S

5794
03:32:21,348 --> 03:32:23,217
SOMETHING THAT WE MUST DO BUT AT

5795
03:32:23,217 --> 03:32:29,756
THE SAME TIME, I THINK THE OTHER

5796
03:32:29,756 --> 03:32:31,291
PORTION IS, WE CAN CONTINUE TO

5797
03:32:31,291 --> 03:32:32,426
HAVE GREAT ADVANCEMENTS AND THEN

5798
03:32:32,426 --> 03:32:34,194
SOMEHOW FIGURE OUT HOW TO BRING

5799
03:32:34,194 --> 03:32:35,729
THOSE ADVANCEMENTS TO ALL

5800
03:32:35,729 --> 03:32:36,330
POPULATIONS.

5801
03:32:36,330 --> 03:32:38,165
NOKAY, SO LET'S WRAP IT UP.

5802
03:32:38,165 --> 03:32:39,366
I THINK THERE'S AN OPPORTUNITY

5803
03:32:39,366 --> 03:32:43,504
PERHAPS FOR THE OCTOBER MEETING

5804
03:32:43,504 --> 03:32:46,340
TO INCLUDE ADVOCACY, PATIENTS

5805
03:32:46,340 --> 03:32:47,474
AND COMMUNITY.

5806
03:32:47,474 --> 03:32:49,576
SO LET'S GO ON TO THE VOTE, THIS

5807
03:32:49,576 --> 03:32:52,746
WILL BE FOR THE NCAB MEMBERS,

5808
03:32:52,746 --> 03:32:54,715
THE VOTE IS TO ACCEPT THE

5809
03:32:54,715 --> 03:32:54,982
REPORT.

5810
03:32:54,982 --> 03:32:58,919
IS THERE A MOTION IN?

5811
03:32:58,919 --> 03:33:01,922
>> SECOND, PROPERLY MOVED
AND

5812
03:33:01,922 --> 03:33:02,923
SECOND, FURTHER DISCUSSION?

5813
03:33:02,923 --> 03:33:05,025
OKAY, WE WILL VOTE.

5814
03:33:05,025 --> 03:33:10,230
ARE THERE ANY NAYS?

5815
03:33:10,230 --> 03:33:11,698
ABSTENTIONS?

5816
03:33:11,698 --> 03:33:12,032
UNANIMOUS.

5817
03:33:12,032 --> 03:33:15,369
SO THE BOARD MEMBERS HAVE A COPY

5818
03:33:15,369 --> 03:33:20,374
OF THE ADHOC SUBCOMMITTEE ON

5819
03:33:20,374 --> 03:33:20,908
EXPERIMENTAL THERAPEUTICS

5820
03:33:20,908 --> 03:33:21,475
REVISED MISSION STATEMENT.

5821
03:33:21,475 --> 03:33:23,210
NOW THAT THE REPORT HAS BEEN

5822
03:33:23,210 --> 03:33:26,113
ACCEPTED, THE BOARD HAS TO ALSO

5823
03:33:26,113 --> 03:33:29,716
VOTE TO ACCEPT OR NOT ACCEPT THE

5824
03:33:29,716 --> 03:33:30,551
NEW MISSION STATEMENT SO IS

5825
03:33:30,551 --> 03:33:33,220
THERE A MOTION TO ACCEPT THE NEW

5826
03:33:33,220 --> 03:33:38,458
MISSION STATEMENT.

5827
03:33:38,458 --> 03:33:40,294
SECOND?

5828
03:33:40,294 --> 03:33:42,195
FURTHER DISCUSSION?

5829
03:33:42,195 --> 03:33:47,568
OKAY, WE'LL VOTE ANY NAYS,

5830
03:33:47,568 --> 03:33:47,868
ABSTENTIONS?

5831
03:33:47,868 --> 03:33:48,235
IT'S UNANIMOUS.

5832
03:33:48,235 --> 03:33:50,003
SO MOVING ON THORS OTHER

5833
03:33:50,003 --> 03:33:53,040
BUSINESS, ARE THERE OTHER

5834
03:33:53,040 --> 03:33:53,707
THOUGHTS, ISSUES, CONCERNS,

5835
03:33:53,707 --> 03:33:54,908
RECOMMENDATIONS THAT ANY OF THE

5836
03:33:54,908 --> 03:33:58,412
BOARD MEMBERS WOULD LIKE TO

5837
03:33:58,412 --> 03:34:01,415
SHARE SORE THAT THE BOARDS AND

5838
03:34:01,415 --> 03:34:06,353
NCI SHOULD CONSIDER GOING

5839
03:34:06,353 --> 03:34:07,688
FORWARD?

5840
03:34:07,688 --> 03:34:07,854
YES?

5841
03:34:07,854 --> 03:34:12,059
>> SO JUST IN THINKING
ABOUT THE

5842
03:34:12,059 --> 03:34:14,127
MORNING, INCREDIBLY AMAZING

5843
03:34:14,127 --> 03:34:15,395
CONVERSATIONS WE'VE HAD, AND

5844
03:34:15,395 --> 03:34:16,330
THINKING ABOUT WHAT WE MIGHT

5845
03:34:16,330 --> 03:34:19,766
WANT TO HEAR MORE ABOUT, I

5846
03:34:19,766 --> 03:34:22,502
WONDERED, I WOULD LOVE TO LEARN

5847
03:34:22,502 --> 03:34:24,871
MORE ABOUT HOW THE NCI, THE NIH

5848
03:34:24,871 --> 03:34:28,141
REALLY COMMUNICATES WITH THE

5849
03:34:28,141 --> 03:34:29,309
PUBLIC.

5850
03:34:29,309 --> 03:34:30,143
LIKE WHAT IS--HOW DOES THAT

5851
03:34:30,143 --> 03:34:32,646
HAPPEN AND WHAT IS THAT PLAN?

5852
03:34:32,646 --> 03:34:34,948
AND THEN TO FOLLOW UP ON, WELL

5853
03:34:34,948 --> 03:34:36,149
WE WERE JUST TALKING ABOUT, IS

5854
03:34:36,149 --> 03:34:43,457
HOW DO WOE ENGAGE WITH

5855
03:34:43,457 --> 03:34:43,757
COMMUNITIES?

5856
03:34:43,757 --> 03:34:44,691
AND SPECIFICALLY ARE THERE

5857
03:34:44,691 --> 03:34:46,560
THOUGHTS, ARE THERE PROJECTS

5858
03:34:46,560 --> 03:34:49,730
THAT ARE AROUND BRINGING

5859
03:34:49,730 --> 03:34:59,606
TOGETHER COMMUNITY HEALTH

5860
03:34:59,606 --> 03:35:00,040
WORKERS.

5861
03:35:00,040 --> 03:35:00,374
>> GREATER.

5862
03:35:00,374 --> 03:35:03,610
>> SAD TO SEE HENRYS LEAVE
THIS

5863
03:35:03,610 --> 03:35:04,911
SPACE WHO HAVE BEEN HERE FOR

5864
03:35:04,911 --> 03:35:07,648
SEVERAL YEARS BUT ALSO I THINK

5865
03:35:07,648 --> 03:35:09,016
CHANGE CAN BE AN OPPORTUNITY TO

5866
03:35:09,016 --> 03:35:10,984
THINK ABOUT HOW THESE ARE

5867
03:35:10,984 --> 03:35:13,954
DIFFERENTLY AND THINK ABOUT

5868
03:35:13,954 --> 03:35:15,455
COMMUNITY ENGAGEMENT I LIKE TO

5869
03:35:15,455 --> 03:35:20,494
PERSONALLY CALL IT I'M WONDERING

5870
03:35:20,494 --> 03:35:21,728
IF THERE MAY BE AN OPPORTUNITY

5871
03:35:21,728 --> 03:35:23,330
TO THINK THROUGH THE CANCER

5872
03:35:23,330 --> 03:35:24,231
CENTERS AND ENGAGE WITH

5873
03:35:24,231 --> 03:35:26,099
COMMUNITIES AND WHAT'S OUR

5874
03:35:26,099 --> 03:35:26,333
MEASURE.

5875
03:35:26,333 --> 03:35:27,734
I KNOW THAT QUESTION HAS GONE UP

5876
03:35:27,734 --> 03:35:34,374
AND DOWN, IN TERMS OF METRICS

5877
03:35:34,374 --> 03:35:35,409
AND EXPECTATIONS ABOUT COMMUNITY

5878
03:35:35,409 --> 03:35:37,177
I PACTS WHICH IS A FRAMEWORK

5879
03:35:37,177 --> 03:35:39,946
THAT EXISTS NOW WITH THE CTSA SO

5880
03:35:39,946 --> 03:35:41,682
THAT'S SOMETHING THAT'S WORTH

5881
03:35:41,682 --> 03:35:45,652
THINKING ABOUT WHO CAN'T CONQUER

5882
03:35:45,652 --> 03:35:47,688
WORLD HUNGER BUT THE IMPACT CAN

5883
03:35:47,688 --> 03:35:50,724
BE POTENTIALLY GREATER ON THE

5884
03:35:50,724 --> 03:35:51,925
COMMUNITIES SO YOU KNOW SITTING

5885
03:35:51,925 --> 03:35:56,830
NEXT TO THE DIRECTOR, BUT I DO

5886
03:35:56,830 --> 03:35:57,330
THINKOOSE AN IMPORTANT

5887
03:35:57,330 --> 03:35:58,498
CONVERSATION THAT MAY BE TIMELY

5888
03:35:58,498 --> 03:36:01,401
TO ARE IN THE CONTEXT OF THE

5889
03:36:01,401 --> 03:36:06,406
WORK, USING IT FOR HEALTH EQUITY

5890
03:36:06,406 --> 03:36:09,042
AND THANK YOU VERY MUCH SO FOR

5891
03:36:09,042 --> 03:36:12,579
THAT THAT THAT'S EXCITING TO

5892
03:36:12,579 --> 03:36:12,813
SHARE.

5893
03:36:12,813 --> 03:36:14,614
THAT'S MY PLUG FOR LOOKINGA THE

5894
03:36:14,614 --> 03:36:21,021
COMMUNITY ENGAGEMENT NTHANK YOU.

5895
03:36:21,021 --> 03:36:21,288
HOWARD?

5896
03:36:21,288 --> 03:36:22,322
NETWORKIDE LIKE TO HEAR MORE

5897
03:36:22,322 --> 03:36:24,624
ABOUT WHERE WE'RE AT IN TERMS OF

5898
03:36:24,624 --> 03:36:26,827
THE MOST RECENT MAJOR INVEST AMS

5899
03:36:26,827 --> 03:36:30,297
BY MOON SHOT IS DONE, FOR

5900
03:36:30,297 --> 03:36:34,601
INITANCE THE SIMAX VALIDATING

5901
03:36:34,601 --> 03:36:37,537
BIOMARKERS TO HELP ACCELERATE

5902
03:36:37,537 --> 03:36:39,406
OUR UNDERSTANDING OF AND

5903
03:36:39,406 --> 03:36:41,775
OPTIMIZING THE IMPORTANT WORK OF

5904
03:36:41,775 --> 03:36:43,643
IMMUNO ONCOLOGY KLUG ANDS

5905
03:36:43,643 --> 03:36:46,813
THERAPIES, AND YOU KNOW EVEN

5906
03:36:46,813 --> 03:36:47,948
OUTSIDE OF SIMAX, THE CHAIN

5907
03:36:47,948 --> 03:36:49,382
ARTICLE I WON'T TALK ABOUT

5908
03:36:49,382 --> 03:36:50,751
FURTHER BECAUSE YOU WILL TALK

5909
03:36:50,751 --> 03:36:53,854
ABOUT IT LATER YOU SAID,

5910
03:36:53,854 --> 03:36:55,122
RECENTLY TOAZ TYPES OF

5911
03:36:55,122 --> 03:36:57,190
APPROACHES THAT ARE HERE NOW,

5912
03:36:57,190 --> 03:36:59,292
BECAUSE IF FOR INSTANCE, IF THE

5913
03:36:59,292 --> 03:37:00,460
BIDEN MOON SHOT FUNDING OR

5914
03:37:00,460 --> 03:37:02,996
SOMETHING LIKE IT COMES, IS

5915
03:37:02,996 --> 03:37:04,131
ALLOWED, HOW ARE WE GOING TO

5916
03:37:04,131 --> 03:37:09,236
BUILD ON WHAT WE'VE LEARNED OR

5917
03:37:09,236 --> 03:37:10,871
WHAT THE COMMUNITY HAS LEARNED.

5918
03:37:10,871 --> 03:37:12,205
WHAT SHOULD THE NEXT STEPS BE IN

5919
03:37:12,205 --> 03:37:15,375
I THINK THAT WOULD BE AN

5920
03:37:15,375 --> 03:37:15,976
INTERESTING THOUGHTFUL

5921
03:37:15,976 --> 03:37:17,577
DISCUSSION, MAYBE HEARING FROM

5922
03:37:17,577 --> 03:37:19,479
PEOPLE LIKE DR. [INDISCERNIBLE]

5923
03:37:19,479 --> 03:37:22,149
OR PEOPLE WHO HAVE BEEN DEEPLY

5924
03:37:22,149 --> 03:37:24,017
INVOLVED WITH THE SIMAX

5925
03:37:24,017 --> 03:37:26,553
PUBLICATIONS THAT HAVE JUST

5926
03:37:26,553 --> 03:37:30,223
STARTED TO COME OUT.

5927
03:37:30,223 --> 03:37:30,991
>> THANKS, HOWARD.

5928
03:37:30,991 --> 03:37:41,468
>> LAST COMMENT FROM KAREN

5929
03:37:49,976 --> 03:37:51,545
BEFORE WE NAND WE DON'T HEAR A

5930
03:37:51,545 --> 03:37:53,213
LOT ABOUT WHAT'S GOING ON IN

5931
03:37:53,213 --> 03:37:56,416
TERMS OF THE NCTN GROUPS ISSUE

5932
03:37:56,416 --> 03:37:57,918
THE NCORP RESEARCH BASES, YOU

5933
03:37:57,918 --> 03:38:00,020
KNOW WHAT THOSE RESEARCH

5934
03:38:00,020 --> 03:38:00,754
PORTFOLIOS LOOK LIKE, WHAT'S

5935
03:38:00,754 --> 03:38:02,055
BEING DONE IN THERE AND WHAT WE

5936
03:38:02,055 --> 03:38:03,123
SHOULD BE THINKING ABOUT DOING

5937
03:38:03,123 --> 03:38:08,295
DIFFERENTLY IN THE FUTURE.

5938
03:38:08,295 --> 03:38:10,030
AND THAT'S A WHOLE OTHER ASPECT

5939
03:38:10,030 --> 03:38:11,565
OF COMMUNITY THERE IN TERMS OF

5940
03:38:11,565 --> 03:38:12,866
THE LAPSE AND NCORPS THAT WE

5941
03:38:12,866 --> 03:38:14,234
DON'T TALK ABOUT VERY MUCH OR

5942
03:38:14,234 --> 03:38:18,805
HEAR ABOUT VERY MUCH IT WOULD BE

5943
03:38:18,805 --> 03:38:20,807
RELLY NICE TO BRING THAT TO THE

5944
03:38:20,807 --> 03:38:22,175
TABLE BECAUSE THERE'S A LOT OF

5945
03:38:22,175 --> 03:38:25,712
BRAIN POWER ON BOTH OF THESE

5946
03:38:25,712 --> 03:38:26,446
COMMUNITIES WHERE POAGHT THOSE

5947
03:38:26,446 --> 03:38:28,348
PROGRAMS ARE GOING IN THE FUTURE

5948
03:38:28,348 --> 03:38:29,216
AND THEY'RE INCREDIBLY POWERFUL

5949
03:38:29,216 --> 03:38:33,119
AND THEIR REACH IS TREMENDOUS.

5950
03:38:33,119 --> 03:38:34,921
SO IT WOULD BE NICE TO BRING

5951
03:38:34,921 --> 03:38:38,024
THAT TO THE TABLE TO THIS GROUP.

5952
03:38:38,024 --> 03:38:38,592
>> THANKS KAREN.

5953
03:38:38,592 --> 03:38:41,761
>> DOCTOR YOU GET THE LAST

5954
03:38:41,761 --> 03:38:42,562
COMMENT.

5955
03:38:42,562 --> 03:38:45,232
>> ONE LAST THING, NCI
SHOULD BE

5956
03:38:45,232 --> 03:38:47,601
MORE INVOLVED IN ADDRESSING

5957
03:38:47,601 --> 03:38:48,101
FINANCIAL TOXICITY.

5958
03:38:48,101 --> 03:38:49,603
I THINK THERE'S A LOT OF

5959
03:38:49,603 --> 03:38:50,537
INDIVIDUAL RESEARCH ANYTHING ON

5960
03:38:50,537 --> 03:38:52,072
BUT SOMETHING COMING UP FROM THE

5961
03:38:52,072 --> 03:38:55,041
NCI COULD BE VERY POWERFUL

5962
03:38:55,041 --> 03:39:01,548
NGREAT, SO IF THERE ARE ANY

5963
03:39:01,548 --> 03:39:03,350
SPECIFIC TOPICS FOR FUTURE

5964
03:39:03,350 --> 03:39:05,986
AGENDA ITEMS, SEND THAT TO THE

5965
03:39:05,986 --> 03:39:07,420
JOINT MEETING INDIVIDUALS, ME OR

5966
03:39:07,420 --> 03:39:08,889
PAULET, IF THERE'S AN INDIVIDUAL

5967
03:39:08,889 --> 03:39:11,091
BOARD SELECTION FOR EITHER NCAB

5968
03:39:11,091 --> 03:39:12,893
OR BSA, SEND THEM EITHER TO

5969
03:39:12,893 --> 03:39:14,661
SHELLY OR PAULET.

5970
03:39:14,661 --> 03:39:17,097
SO, WE'LL NOW BREAK FOR LUNCH.

5971
03:39:17,097 --> 03:39:18,498
IT'S BEEN AN INCREDIBLE MORNING,

5972
03:39:18,498 --> 03:39:20,934
IT'S GREAT SEEING THE FACES AND

5973
03:39:20,934 --> 03:39:22,202
THE DYNAMICS AND THE BODY

5974
03:39:22,202 --> 03:39:23,737
LANGUAGE IT'S MUCH BETTER THAN

5975
03:39:23,737 --> 03:39:26,940
THE VIRTUAL APPROACH I HAVE TO

5976
03:39:26,940 --> 03:39:28,841
SAY, IT'S FANTASTIC,

5977
03:39:28,841 --> 03:39:29,909
GOOD AFTERNOON, THANK YOU ALL

5978
03:39:29,909 --> 03:39:32,578
FOR THE OPPORTUNITY TO PRESENT

5979
03:39:32,578 --> 03:39:34,781
OUR RFOOTWORKA CONCEPTS, THE

5980
03:39:34,781 --> 03:39:36,616
CONFLUENCE OF CANCER STIGMA AND

5981
03:39:36,616 --> 03:39:38,451
HIV STIGMA AND HIV POSITIVE

5982
03:39:38,451 --> 03:39:39,719
INDIVIDUALS DIAGNOSED WITH

5983
03:39:39,719 --> 03:39:41,154
CANCER, IT'S MY HONOR TO PRESENT

5984
03:39:41,154 --> 03:39:42,922
THIS WORK ON BEHALF OF MULTIPLE

5985
03:39:42,922 --> 03:39:47,794
PARTNERS HERE AT NCI.

5986
03:39:47,794 --> 03:39:49,061
FOR CONTEXT, WE RECOGNIZE

5987
03:39:49,061 --> 03:39:50,797
THERE'S STILL A TREMENDOUS

5988
03:39:50,797 --> 03:39:54,467
BURDEN OF HIV AROUND THE WORLD.

5989
03:39:54,467 --> 03:39:55,301
DPLOABALLY THERE ARE 39 MILLION

5990
03:39:55,301 --> 03:39:58,104
INDIVIDUALS LIVING WITH HIV AND

5991
03:39:58,104 --> 03:40:00,573
1.2 MILLION INDIVIDUALS HERE IN

5992
03:40:00,573 --> 03:40:01,140
THE UNITED STATES.

5993
03:40:01,140 --> 03:40:03,476
AMONG PEOPLE WITH HIV, ELEVATED

5994
03:40:03,476 --> 03:40:05,945
CANCER RISK IS INFLUENCED BY

5995
03:40:05,945 --> 03:40:07,814
MULTIPLE FACTORS ENCLOUDING CO

5996
03:40:07,814 --> 03:40:09,315
INFECTION WITH ONCOGENIC

5997
03:40:09,315 --> 03:40:10,750
VIRUSES, HIGHER PREVALENCE OF

5998
03:40:10,750 --> 03:40:14,153
BEHAVIORIAL RISK FACTORS SUCH AS

5999
03:40:14,153 --> 03:40:15,555
TOBACCO USE, INCREASED LIFE

6000
03:40:15,555 --> 03:40:17,056
EXPECTANCY AND DEVELOPMENT OF

6001
03:40:17,056 --> 03:40:18,591
MORE COMMON CANCERS AND

6002
03:40:18,591 --> 03:40:19,525
SOCIOLOGICAL CULTURAL FACTORS

6003
03:40:19,525 --> 03:40:23,663
AND ACCESS TO CARE BARRIERS,

6004
03:40:23,663 --> 03:40:24,497
THAT INCREASE--THAT CONTRIBUTE

6005
03:40:24,497 --> 03:40:25,998
TO INCREASED RISK AND POOR

6006
03:40:25,998 --> 03:40:27,934
OUTCOMES FOR BOTH DISEASES.

6007
03:40:27,934 --> 03:40:29,936
WHEN A PERSON WITH HIV IS

6008
03:40:29,936 --> 03:40:31,571
DIAGNOSED WITH CANCER, THERE IS

6009
03:40:31,571 --> 03:40:34,407
A POWERFUL AND COMBINED IMPACT

6010
03:40:34,407 --> 03:40:36,309
ON THE PATIENT, INCLUDING POOR

6011
03:40:36,309 --> 03:40:38,978
CANCER SURVIVAL AND INCREASED

6012
03:40:38,978 --> 03:40:40,213
CANCER MORTALITY RATES.

6013
03:40:40,213 --> 03:40:42,448
THESE OUTCOMES RESULT FROM A

6014
03:40:42,448 --> 03:40:43,816
COMBINATION OF PATIENT PROVIDER

6015
03:40:43,816 --> 03:40:47,353
AND SYSTEM LEVEL FACTORS SUCH AS

6016
03:40:47,353 --> 03:40:47,987
CO-MORBIDITIES,

6017
03:40:47,987 --> 03:40:51,023
IMMUNOSUPPRESSION, TREATMENT AND

6018
03:40:51,023 --> 03:40:51,924
SURVIVORSHIP DISPARITIES,

6019
03:40:51,924 --> 03:40:53,392
PROVIDER DISCRIMINATION AND POOR

6020
03:40:53,392 --> 03:40:56,262
CARE ACCORD NATION AND THE

6021
03:40:56,262 --> 03:40:57,797
CUMULATIVE BURDEN OF COPING WITH

6022
03:40:57,797 --> 03:41:02,535
AND MANAGING BOTH DISEASES.

6023
03:41:02,535 --> 03:41:04,504
AS POIGNANTLY STATED IN OUR

6024
03:41:04,504 --> 03:41:05,438
RECENT ONCOLOGY ARTICLE, THE

6025
03:41:05,438 --> 03:41:06,939
PRESENCE OF LIVING WITH BOALGT

6026
03:41:06,939 --> 03:41:08,808
HIV AND CANCER IS DISTINCT FROM

6027
03:41:08,808 --> 03:41:12,211
THE EXPERIENCE OF LIVING WITH

6028
03:41:12,211 --> 03:41:13,479
HIV OR CANCER.

6029
03:41:13,479 --> 03:41:15,481
AND IMPORTANTLY, EMBEDDED WITHIN

6030
03:41:15,481 --> 03:41:17,016
THE DISTINCT EXPERIENCE OF A

6031
03:41:17,016 --> 03:41:18,985
DUAL DIAGNOSIS OF CANCER AND

6032
03:41:18,985 --> 03:41:23,656
HIV, IS THE POWERFUL SOCIAL

6033
03:41:23,656 --> 03:41:25,124
PHENOMENON OF STIGMA.

6034
03:41:25,124 --> 03:41:26,392
STIGNAIS AN ATTRIBUTE OR

6035
03:41:26,392 --> 03:41:27,360
CHARACTERISTIC SUCH AS BEING

6036
03:41:27,360 --> 03:41:29,428
DIAGNOSED WITH CANCER OR HIV,

6037
03:41:29,428 --> 03:41:31,998
THAT IS DEEPLY DISCREDITING,

6038
03:41:31,998 --> 03:41:33,366
LEADING TO BLAME, DISCRIMINATION

6039
03:41:33,366 --> 03:41:36,569
AND REYEKS AMONG OTHER NEGATIVE

6040
03:41:36,569 --> 03:41:36,869
CONS QUENSS.

6041
03:41:36,869 --> 03:41:38,070
TIGER DATABASE MA IS MULTILEVEL

6042
03:41:38,070 --> 03:41:40,506
IN NATURE AND CAN BE FELT OR

6043
03:41:40,506 --> 03:41:42,108
INTERNALIZED BY THE INDIVIDUAL

6044
03:41:42,108 --> 03:41:44,410
WHO IS BEING STIGMATIZED AND

6045
03:41:44,410 --> 03:41:46,846
ACTED BY OTHERS SUCH AS

6046
03:41:46,846 --> 03:41:48,014
DISCRIMINATION, EMBEDDED WITHIN

6047
03:41:48,014 --> 03:41:51,817
SYSTEMS AND STRUCTURES RESULTING

6048
03:41:51,817 --> 03:41:54,854
IN DESPERATE TREATMENT. 

6049
03:41:54,854 --> 03:41:58,791
STIGMA IS ALSO MULTIDIMENSIONAL.

6050
03:41:58,791 --> 03:42:00,459
FOR EXAMPLE, STIGMA MAY BE

6051
03:42:00,459 --> 03:42:02,328
HEIGHTENED WHEN AN INDIVIDUAL IS

6052
03:42:02,328 --> 03:42:03,496
PERCEIVED AS RESPONSIBLE FOR

6053
03:42:03,496 --> 03:42:05,264
THEIR HEALTH CONDITION DUE TO

6054
03:42:05,264 --> 03:42:06,632
RISKY SEXUAL BEHAVIORS OR

6055
03:42:06,632 --> 03:42:09,001
TOBACCO USE, OR THE DECS

6056
03:42:09,001 --> 03:42:10,236
PERCEIVED AS CONTAGIOUS, OR THE

6057
03:42:10,236 --> 03:42:15,074
DISEASE IS VISIBLE TO OTHERS,

6058
03:42:15,074 --> 03:42:16,275
SUCH AS CARPOSI'S SARCOMA OR THE

6059
03:42:16,275 --> 03:42:17,577
SIDE EEIVETS OF CANCER

6060
03:42:17,577 --> 03:42:19,545
TREATMENT, THIS R, IFA FOCUSES

6061
03:42:19,545 --> 03:42:21,480
ON INDIVIDUALS WITH A DUAL

6062
03:42:21,480 --> 03:42:22,915
DIAGNOSE OF HIV AND CANCER AS

6063
03:42:22,915 --> 03:42:25,017
THEY HAVE AN INCREASE RISK OF

6064
03:42:25,017 --> 03:42:27,320
NEGATIVE CANCER OUTCOMES GIVEN

6065
03:42:27,320 --> 03:42:28,621
THEY EXPERIENCE TIGER DATABASE

6066
03:42:28,621 --> 03:42:34,393
MA SOCIALITIED WITH BOTH HEALTH

6067
03:42:34,393 --> 03:42:34,694
ATTRIBUTES.

6068
03:42:34,694 --> 03:42:35,528
TRADITIONALLY HIV STIGMA AND

6069
03:42:35,528 --> 03:42:36,996
CANCER TIGER DATABASE MA HAVE

6070
03:42:36,996 --> 03:42:37,930
BEEN STUDIED INDEPENDENTLY.

6071
03:42:37,930 --> 03:42:39,432
OVER THE LAST 4 YEARS THERE'S

6072
03:42:39,432 --> 03:42:41,200
BEEN A SIGNIFICANT EVIDENT BASE

6073
03:42:41,200 --> 03:42:42,368
ESTABLISHED REGARDING THE NEG5

6074
03:42:42,368 --> 03:42:43,803
EFFECTS OF HIV TIGER DATABASE MA

6075
03:42:43,803 --> 03:42:45,471
AND THERE'S A GROWING FIELD OF

6076
03:42:45,471 --> 03:42:47,440
RESEARCH ON THE NEGATIVE IMPACTS

6077
03:42:47,440 --> 03:42:48,808
ASSOCIATE WIDE CANCER STIGMA.

6078
03:42:48,808 --> 03:42:50,343
A FEW EXAMPLES OF THE NEG5

6079
03:42:50,343 --> 03:42:51,544
EFFECTS OF EACH STIGMA ARE

6080
03:42:51,544 --> 03:42:57,984
HIGHLIGHTED ON THE CURRENT SLIDE

6081
03:42:57,984 --> 03:42:59,018
HOWEVER, THERE IS LIMITED

6082
03:42:59,018 --> 03:43:01,554
RESEARCH ON THE CONFLUENCE OF

6083
03:43:01,554 --> 03:43:03,723
THE 2 STIGMAS WITH PEOPLE WITH

6084
03:43:03,723 --> 03:43:04,256
HIV AND CANCER.

6085
03:43:04,256 --> 03:43:06,626
WE KNOW FROM THE BROADER

6086
03:43:06,626 --> 03:43:09,829
LITERATURE THAT STIGMAS ARE NOT

6087
03:43:09,829 --> 03:43:10,863
ADDITIVE OR RATHER INTERACTIVE

6088
03:43:10,863 --> 03:43:12,431
AND LIKELY SUCH THAT THE

6089
03:43:12,431 --> 03:43:13,466
COMBINATION OF HIV STIGMA AND

6090
03:43:13,466 --> 03:43:15,001
CANCER TIGER DATABASE MA HAS A

6091
03:43:15,001 --> 03:43:15,968
POWERFUL IMPACT THAT GOES WELL

6092
03:43:15,968 --> 03:43:18,504
BEYOND THE EFFECT OF EITHER

6093
03:43:18,504 --> 03:43:18,838
ALONE.

6094
03:43:18,838 --> 03:43:21,774
CANCER OUTCOMES HYPOTH SIZE TO

6095
03:43:21,774 --> 03:43:23,609
BE NEGATIVELYEC AFFECTED BY THE

6096
03:43:23,609 --> 03:43:25,311
CONVERGENCE OF CANCER TIGER

6097
03:43:25,311 --> 03:43:28,514
DATABASE MA AND IPT GREATER

6098
03:43:28,514 --> 03:43:30,282
CREASE ACCESS HEALTHCARE

6099
03:43:30,282 --> 03:43:31,517
UTILIZATION, INITIATION AND

6100
03:43:31,517 --> 03:43:33,753
COMPLETION OF CANCER GUIDELINE

6101
03:43:33,753 --> 03:43:34,320
TREATMENT, PARTICIPATION IN

6102
03:43:34,320 --> 03:43:35,621
CLINICAL TRIALS, QUALITY OF LIFE

6103
03:43:35,621 --> 03:43:37,490
AND PSYCHOSOCIAL WELL BEING, AND

6104
03:43:37,490 --> 03:43:39,458
THE ENGAGEMENT AND HEALTHY

6105
03:43:39,458 --> 03:43:41,694
BEHAVIORS SUCH AS TOBACCO

6106
03:43:41,694 --> 03:43:42,762
CESSATION, SCREENING FOR

6107
03:43:42,762 --> 03:43:44,497
SECONDARY CANCERS AND MONITORING

6108
03:43:44,497 --> 03:43:46,599
RISK OF RECURRENCE AMONG OTHER

6109
03:43:46,599 --> 03:43:46,866
OUTCOMES.

6110
03:43:46,866 --> 03:43:49,435
MORE RESEARCH IS NEEDED TO

6111
03:43:49,435 --> 03:43:51,070
UNDERSTAND AND ADDRESS THE

6112
03:43:51,070 --> 03:43:52,271
COMBINED IMPACT OF BOTH STIGMAS

6113
03:43:52,271 --> 03:43:55,341
ON PEOPLE WITH HIV AND CANCER,

6114
03:43:55,341 --> 03:43:56,842
PARTICULARLY GIVEN THE DIVERSE

6115
03:43:56,842 --> 03:43:57,777
SOCIOLOGICAL CULTURAL AND

6116
03:43:57,777 --> 03:44:00,079
HEALTHCARE CONTEXT HERE IN THE

6117
03:44:00,079 --> 03:44:03,416
U.S. AND AROUND THE WORLD.

6118
03:44:03,416 --> 03:44:05,751
AS SUCH THE GOALS OF AN RFA WILL

6119
03:44:05,751 --> 03:44:07,486
BE TO EXPAND THE CURRENT

6120
03:44:07,486 --> 03:44:09,221
UNDERSTANDING OF THE CONVERGENCE

6121
03:44:09,221 --> 03:44:11,657
OF CANCER STIGMA AND HIV STIGMA

6122
03:44:11,657 --> 03:44:13,259
AMONG HIV IN PEOPLE WITH CANCER

6123
03:44:13,259 --> 03:44:15,561
AND ASSESS THE IMPACT OF THESE

6124
03:44:15,561 --> 03:44:18,230
DUAL STIGMAS ON CANCER OUTCOMES,

6125
03:44:18,230 --> 03:44:19,732
LEVERAGE STIGMA REDUCTION

6126
03:44:19,732 --> 03:44:21,033
INTERVENTIONS AT MULTIPLE LEVELS

6127
03:44:21,033 --> 03:44:22,902
TO INTERVENE ON MECHANISMS OF

6128
03:44:22,902 --> 03:44:25,771
STIGMA AND PROMOTE RESEARCH AND

6129
03:44:25,771 --> 03:44:29,241
DIVERSE DOMESTIC AND

6130
03:44:29,241 --> 03:44:30,443
INTERNATIONAL CONTESTS, EXAMPLE

6131
03:44:30,443 --> 03:44:32,745
RESEARCH TOPICS RESPONSIVE TO

6132
03:44:32,745 --> 03:44:33,779
THIS RFA INCLUDE LONGITUDINAL

6133
03:44:33,779 --> 03:44:36,449
STUDIES TO ASSESS THE IMPACT OF

6134
03:44:36,449 --> 03:44:37,983
CANCER STIGMA AND HIV STIGMA ON

6135
03:44:37,983 --> 03:44:39,719
CANCER OUTCOMES AND STUDIES THAT

6136
03:44:39,719 --> 03:44:41,253
INVESTIGATOR FACTORS THAT EITHER

6137
03:44:41,253 --> 03:44:42,388
EXACERBATE OR MITIGATE THE

6138
03:44:42,388 --> 03:44:45,124
ASSOCIATION OF THE DUAL STIGMAS

6139
03:44:45,124 --> 03:44:46,792
WITH CANCER OUTCOMES AND STUDIES

6140
03:44:46,792 --> 03:44:50,529
THAT DEVELOP AND EVALUATE STIGMA

6141
03:44:50,529 --> 03:44:51,497
REDUCTION INTERVENTIONS

6142
03:44:51,497 --> 03:44:52,932
IMPLEMENTED AT INDIVIDUAL,

6143
03:44:52,932 --> 03:44:54,266
PROVIDER, COMMUNITY AND/OR

6144
03:44:54,266 --> 03:44:55,801
STRUCTURAL LEVELS TO IMPROVE

6145
03:44:55,801 --> 03:44:59,238
CANCER OUTCOMES IN PEOPLE WITH

6146
03:44:59,238 --> 03:45:01,040
HIV CANCER.

6147
03:45:01,040 --> 03:45:03,109
TO DEDICATED RFAs WOULD DEMON

6148
03:45:03,109 --> 03:45:03,943
TRAIT THIS HIGH PRIORITY

6149
03:45:03,943 --> 03:45:06,479
RESEARCH AREA AS WELL AS SUPPORT

6150
03:45:06,479 --> 03:45:08,080
A BOLUS OF TRANSDISCIPLINARY

6151
03:45:08,080 --> 03:45:10,783
RESEARCH PROGECS LED BY DOMESTIC

6152
03:45:10,783 --> 03:45:11,617
AND INTERNATIONAL INVESTIGATIVE

6153
03:45:11,617 --> 03:45:12,051
TEAMS.

6154
03:45:12,051 --> 03:45:14,453
WE ARE PROPOSING TO FIND 5-6

6155
03:45:14,453 --> 03:45:18,624
RO-1S AND 3 R21S FOR A TOTAL OF

6156
03:45:18,624 --> 03:45:20,059
6 MILLION IN YORE 1 AND

6157
03:45:20,059 --> 03:45:24,363
27 MILLION OVER THE 5 YEAR

6158
03:45:24,363 --> 03:45:24,697
INITIATIVE.

6159
03:45:24,697 --> 03:45:27,166
WE MET WITH OUR BSA REVIEWERS

6160
03:45:27,166 --> 03:45:29,368
LAST WEEK TO DISCUSS THEIR

6161
03:45:29,368 --> 03:45:30,536
INSIGHTFUL FEEDBACKOT FUNDING

6162
03:45:30,536 --> 03:45:32,705
CONACCEPT ANDsA RAY SUMMIT WE

6163
03:45:32,705 --> 03:45:36,242
HAVE FURTHER CLARIFIED SEVERAL

6164
03:45:36,242 --> 03:45:37,209
IMPORTANT POINTS.

6165
03:45:37,209 --> 03:45:38,477
REGARDING SCOPE, WE ARE ASKING

6166
03:45:38,477 --> 03:45:39,879
INVESTIGATORS TO FOCUS ON THE

6167
03:45:39,879 --> 03:45:41,447
AACTUALITY POPULATION AS THE

6168
03:45:41,447 --> 03:45:43,783
DUAL STIGMA EXPERIENCE AND

6169
03:45:43,783 --> 03:45:45,985
MECHANISMS ARE LIKELY TO DIFFER

6170
03:45:45,985 --> 03:45:46,752
SUBSTANTIALLY BETWEEN ARK DULT

6171
03:45:46,752 --> 03:45:49,889
ANDS CHILDREN, AND WE ARE HOPING

6172
03:45:49,889 --> 03:45:51,457
THE INVESTIGATORS WILL CONSIDER

6173
03:45:51,457 --> 03:45:53,359
THOSE WITH ONCOGENIC VIRUSES,

6174
03:45:53,359 --> 03:45:54,293
BEHAVIORIAL RISK FACTORS, CANC

6175
03:45:54,293 --> 03:45:56,729
XER AGING AND OTHER SOCIOLOGICAL

6176
03:45:56,729 --> 03:45:58,497
CULTURAL FACTORS THAT ARE MORE

6177
03:45:58,497 --> 03:45:59,999
RELEVANT TO AN ADULT PATIENT

6178
03:45:59,999 --> 03:46:00,299
POPULATION.

6179
03:46:00,299 --> 03:46:01,534
ENEMY ARK DITION THE RFANATICA

6180
03:46:01,534 --> 03:46:02,935
WILL PROMOTE CONSIDERATION OF

6181
03:46:02,935 --> 03:46:04,570
ALL CANCER SITES AS WE WANT

6182
03:46:04,570 --> 03:46:06,939
INVESTIGATORS TO EXPLORE THE

6183
03:46:06,939 --> 03:46:08,440
DUAL STIGMA EXPERIENCE BASED ON

6184
03:46:08,440 --> 03:46:10,643
DIFFERENT COMBINATIONS OF HIV

6185
03:46:10,643 --> 03:46:11,544
AND CANCER DIAGNOSIS.

6186
03:46:11,544 --> 03:46:13,379
FOR EXAMPLE, THE HIV AND

6187
03:46:13,379 --> 03:46:14,980
PROSTATE CANCER EXPERIENCE IS

6188
03:46:14,980 --> 03:46:18,784
LIKELY VERY DIFFERENT THAN HIV

6189
03:46:18,784 --> 03:46:21,654
IN CARPOSI SARCOMA OR HIV IN

6190
03:46:21,654 --> 03:46:23,055
LUNG CANCER COMPARED TO HIV AND

6191
03:46:23,055 --> 03:46:24,123
CERVICAL CANCER AND THESE

6192
03:46:24,123 --> 03:46:26,425
EXPERIENCES ARE ALSO DEPENDENTOT

6193
03:46:26,425 --> 03:46:28,494
DOMESTIC OR INTERNATIONAL TODAY

6194
03:46:28,494 --> 03:46:29,428
SETTING INCLUDING CULTURAL

6195
03:46:29,428 --> 03:46:30,863
BELIEFS AND SOCIAL ANDIENDER

6196
03:46:30,863 --> 03:46:34,200
NORMS AND THE GEOGRAPHIC AREAS

6197
03:46:34,200 --> 03:46:35,301
INCIDENCE PREVALENCE OR

6198
03:46:35,301 --> 03:46:36,769
MORTALITY RELATED TO HIV AND

6199
03:46:36,769 --> 03:46:37,736
CANCER WHICH THE INVESTIGATORS

6200
03:46:37,736 --> 03:46:43,843
ARE ASKED TO CAREFULLY CONSIDER

6201
03:46:43,843 --> 03:46:44,143
AND JUSTIFY.

6202
03:46:44,143 --> 03:46:46,846
GIVEN THE PREMISE OF THE RFA

6203
03:46:46,846 --> 03:46:48,347
CONCEPT, AMONG DUAL STIGMAS WITH

6204
03:46:48,347 --> 03:46:50,683
PEOPLE WITH HIV AND CANCER, IN

6205
03:46:50,683 --> 03:46:51,684
ADDITION APPLICATION SHOULD

6206
03:46:51,684 --> 03:46:53,652
CONSIDER THE INTERSECTION OF

6207
03:46:53,652 --> 03:46:55,054
OTHER RELEVANT IDENTITY BASED

6208
03:46:55,054 --> 03:46:57,456
STIGMAS THAT ARE EXPERIENCED BY

6209
03:46:57,456 --> 03:47:00,593
INDIVIDUALS OF DIFFERENT RACES

6210
03:47:00,593 --> 03:47:01,760
AND ETHNICITIES, SOCIOECONOMIC

6211
03:47:01,760 --> 03:47:03,863
STATUS, OCCUPATIONS AND SEXUAL

6212
03:47:03,863 --> 03:47:06,031
AND GENDER IDENTITIES AS

6213
03:47:06,031 --> 03:47:06,832
APPROPRIATE.

6214
03:47:06,832 --> 03:47:07,666
CANCER OUTCOMES ARE PRIMARY

6215
03:47:07,666 --> 03:47:09,768
INTEREST AND WILL BE REQUIRED BY

6216
03:47:09,768 --> 03:47:11,170
THE RFA, HOWEVER APPLICATIONS

6217
03:47:11,170 --> 03:47:14,540
MAY ALSO ENCLUED HIV OUTCOMES.

6218
03:47:14,540 --> 03:47:15,407
LASTLY, TO INSURE ROBUST

6219
03:47:15,407 --> 03:47:17,943
RESPONSE TO THE RFA, WE WILL

6220
03:47:17,943 --> 03:47:19,078
DEVELOP AND IMPLEMENT A

6221
03:47:19,078 --> 03:47:21,447
COMMUNICATION PLAN WITH OUR NIH

6222
03:47:21,447 --> 03:47:23,148
AND NCI COLLEAGUES THAT IS

6223
03:47:23,148 --> 03:47:24,783
DESIGNED TO REACH DOMESTIC AND

6224
03:47:24,783 --> 03:47:30,289
INTERNATIONALLY HIV AND CANCER

6225
03:47:30,289 --> 03:47:33,025
RESEARCH AND ADVOCACY

6226
03:47:33,025 --> 03:47:34,660
COMMUNITIES AND PROMOTE

6227
03:47:34,660 --> 03:47:35,361
TRANSDISCIPLINE ANNIE

6228
03:47:35,361 --> 03:47:35,828
APPLICATIONS.

6229
03:47:35,828 --> 03:47:38,030
WE WILL ALSO PUBLISH THE NOTICE

6230
03:47:38,030 --> 03:47:41,934
IN THE NIH GUIDE AND AS WELL AS

6231
03:47:41,934 --> 03:47:43,002
HOST A PREAPPLICATION WEBINAR.

6232
03:47:43,002 --> 03:47:44,637
THANK YOU FOR THE OPPORTUNITY TO

6233
03:47:44,637 --> 03:47:45,471
PRESENT THIS RFOOTWORKA COB

6234
03:47:45,471 --> 03:47:47,006
SEPTORS AND I LOOK FORWARD TO

6235
03:47:47,006 --> 03:47:48,641
YOUR QUESTIONS NROBIN THAT WAS

6236
03:47:48,641 --> 03:47:50,542
AN EXEMPLARY AND VERY SHORT AND

6237
03:47:50,542 --> 03:47:53,812
WONDERFUL PRESENTATION, THANK

6238
03:47:53,812 --> 03:47:53,979
YOU.

6239
03:47:53,979 --> 03:47:58,017
LET'S HEAR FROM THE CHAIR OF THE

6240
03:47:58,017 --> 03:47:58,717
COMMITTEE.

6241
03:47:58,717 --> 03:48:00,886
>> WELL, YOU TOOK AWAY MY
SAILS

6242
03:48:00,886 --> 03:48:02,388
SO THAT WAS BASICALLY MY

6243
03:48:02,388 --> 03:48:03,889
RESPONSE TO THE MING AND

6244
03:48:03,889 --> 03:48:08,193
APPRECIATE ALL THE CHANGES

6245
03:48:08,193 --> 03:48:09,395
MODIFICATIONS YOU MADE 3 OR 4

6246
03:48:09,395 --> 03:48:10,796
SIDED CHANCE TO MEET WITH THIS

6247
03:48:10,796 --> 03:48:13,465
TEAM DEVELOPING IN RFA WERE

6248
03:48:13,465 --> 03:48:14,733
ENTHUSIASTIC ABOUT IT AND THE

6249
03:48:14,733 --> 03:48:15,868
AREA OF THAT INTERSECTION

6250
03:48:15,868 --> 03:48:17,202
BETWEEN 1 POINT OF CLARITY WEAN

6251
03:48:17,202 --> 03:48:21,941
PEOPLE WITH CANCER AND WITH HIV,

6252
03:48:21,941 --> 03:48:24,043
IS 1 THAT UNDEREXPLORERS CAN

6253
03:48:24,043 --> 03:48:27,313
AFFECT THE ACCESS AND OUTCOMES

6254
03:48:27,313 --> 03:48:28,847
OF CARE MOST OF IF NOT ALL OF

6255
03:48:28,847 --> 03:48:32,418
THE QUESTIONS WERE RAISED EXOFF

6256
03:48:32,418 --> 03:48:33,585
THIVELY SO I'M NOT SURE I HAVE

6257
03:48:33,585 --> 03:48:36,488
MUCH MORE TO ADD TO IT, I THINK

6258
03:48:36,488 --> 03:48:39,491
STILL THE POINTS BEING MADE ARE

6259
03:48:39,491 --> 03:48:42,594
CLARIFYING MORE WHEN TALKING

6260
03:48:42,594 --> 03:48:43,662
ABOUT CANCER OUTCOMES, WHAT THAT

6261
03:48:43,662 --> 03:48:45,898
IS EXPLAINED TO BE, RIGHT IN

6262
03:48:45,898 --> 03:48:47,366
BECAUSE CANCER OUTCOMES, WILL

6263
03:48:47,366 --> 03:48:49,902
STILL MEAN TREATMENT OUTCOMES,

6264
03:48:49,902 --> 03:48:51,370
SO CANCER MORTALITY AND SURVIVAL

6265
03:48:51,370 --> 03:48:52,538
OUTCOMES AND I THINK SOME OF

6266
03:48:52,538 --> 03:48:53,505
THAT CLARITY MAY BE HELPFUL TO

6267
03:48:53,505 --> 03:48:57,276
THOSE WHO ARE TRYING TO CLARIFY

6268
03:48:57,276 --> 03:49:00,079
AND THE COURSE OF THE

6269
03:49:00,079 --> 03:49:00,913
PREAPPLICATION WEBINAR PROCESS.

6270
03:49:00,913 --> 03:49:04,183
BUT I'M EXCITED ABOUT IT BECAUSE

6271
03:49:04,183 --> 03:49:05,918
IT'S AN AREA REALLY IMPORTANT

6272
03:49:05,918 --> 03:49:08,454
AREA, THE ISSUES OF ORIGIN

6273
03:49:08,454 --> 03:49:11,724
STIGMA MA WHICH IS THE CAUSE OF

6274
03:49:11,724 --> 03:49:14,393
THE DISEASE AND YOU VERSUS FOR

6275
03:49:14,393 --> 03:49:16,562
IT VERSUS SOMEONE WHO MAY NOT

6276
03:49:16,562 --> 03:49:17,529
HAVE THE PERSISTENCE OF

6277
03:49:17,529 --> 03:49:19,865
RESPONSIBILITY COULD BE AN

6278
03:49:19,865 --> 03:49:20,099
ISSUE.

6279
03:49:20,099 --> 03:49:23,569
SO I AM GOING TO GIVE IT OVER TO

6280
03:49:23,569 --> 03:49:27,339
ANDY AND JEN TO GIVE THEIR

6281
03:49:27,339 --> 03:49:27,606
THOUGHTS.

6282
03:49:27,606 --> 03:49:30,576
>> YEAH, THAT WAS AN
EXCELLENT

6283
03:49:30,576 --> 03:49:31,977
PRESENTATION AND I REALLY

6284
03:49:31,977 --> 03:49:33,045
APPRECIATED THE INCORPORATION OF

6285
03:49:33,045 --> 03:49:36,882
THE FEEDBACK, I THINK IT'S A

6286
03:49:36,882 --> 03:49:39,385
REALLY IMPORTANT AREA AND I

6287
03:49:39,385 --> 03:49:40,119
PARTICULARLY THINK IT'S

6288
03:49:40,119 --> 03:49:42,221
IMPORTANT TO KIND OF ALSO

6289
03:49:42,221 --> 03:49:45,124
CONSIDER THE OTHER SOURCES OF

6290
03:49:45,124 --> 03:49:46,392
SIGMA ON HAVING THIS DISEASE

6291
03:49:46,392 --> 03:49:49,595
WHICH IS AN IMPORTANT ROLE AND I

6292
03:49:49,595 --> 03:49:51,597
THINK THAT WILL BE A KEY THING

6293
03:49:51,597 --> 03:49:57,770
FOR APPLICANTS TO HOPEFULLY

6294
03:49:57,770 --> 03:49:58,504
ADDRESS EMPLOY NAGAIN, THAIRNG

6295
03:49:58,504 --> 03:49:59,838
YOU FOR THE EXCELLENT

6296
03:49:59,838 --> 03:50:00,739
PRESENTATION LAST WEEK AND THIS

6297
03:50:00,739 --> 03:50:02,608
WEEK AND THANK YOU FOR

6298
03:50:02,608 --> 03:50:03,442
ADDRESSING THE PEDIATRIC

6299
03:50:03,442 --> 03:50:05,277
POPULATION AND THE GEOGRAPHIC

6300
03:50:05,277 --> 03:50:09,014
DISTRIBUTION OF THIS AND YOU'RE

6301
03:50:09,014 --> 03:50:10,916
RIGHT, IT'S NOT [INDISCERNIBLE],

6302
03:50:10,916 --> 03:50:14,219
1 PLACE HERE IS NOT 1, IT'S 1

6303
03:50:14,219 --> 03:50:16,488
PLACE AND LIKELY 4 OR 5 SO 1

6304
03:50:16,488 --> 03:50:17,723
QUICK QUESTION YOU HAD ANSWERED

6305
03:50:17,723 --> 03:50:18,957
LAST WEEK BUT FOR THE BIGGER

6306
03:50:18,957 --> 03:50:20,592
GROUP HERE IS THE INTERVENTIONS

6307
03:50:20,592 --> 03:50:22,461
ARE THEY GOING TO BE BEHAVIORIAL

6308
03:50:22,461 --> 03:50:25,798
OR THERAPEUTIC OR BOTH?

6309
03:50:25,798 --> 03:50:26,465
>> BEHAVIORIAL.

6310
03:50:26,465 --> 03:50:29,768
BEHAVIORIAL ALONG WITH OTHER

6311
03:50:29,768 --> 03:50:33,238
OPPORTUNITIES, YOU KNOW I THINK

6312
03:50:33,238 --> 03:50:35,140
YOU CAN INTERVENTION WITH THE

6313
03:50:35,140 --> 03:50:35,974
INDIVIDUALS AND AMONG PROVIDERS

6314
03:50:35,974 --> 03:50:37,342
AND EVEN WITHIN A HEALTHCARE

6315
03:50:37,342 --> 03:50:39,178
SYSTEM SETTING AS WELL AND

6316
03:50:39,178 --> 03:50:40,245
COMMUNITY SETTINGS BUT ALSO

6317
03:50:40,245 --> 03:50:45,017
THINKING ABOUT HOW WE CAN

6318
03:50:45,017 --> 03:50:48,153
USE--THERE'S ACTUALLY A STUDY

6319
03:50:48,153 --> 03:50:49,421
WITH CAPOSI'S SARCOMA PATIENTS

6320
03:50:49,421 --> 03:50:51,156
DIAGNOSED WITH HIV WERE ACTUALLY

6321
03:50:51,156 --> 03:50:54,026
MAKING SURE THAT RECEIVED THEIR

6322
03:50:54,026 --> 03:50:56,195
CANCER TREATMENT WAS A STIGMA

6323
03:50:56,195 --> 03:50:56,929
REDUCTION INTERVENTION BECAUSE

6324
03:50:56,929 --> 03:50:59,998
THEN THEY GOT BETTER AND THEIR

6325
03:50:59,998 --> 03:51:02,868
CANCER WAS BEING TREATED AND

6326
03:51:02,868 --> 03:51:04,503
THAT--SO WELL IS I GUESS IN A

6327
03:51:04,503 --> 03:51:05,804
SENSE A MEDICAL INTERVENTION IN

6328
03:51:05,804 --> 03:51:08,540
THAT POINT OF DELIVERING THEIR

6329
03:51:08,540 --> 03:51:09,141
ACTUAL CANCER, RECOMMENDED

6330
03:51:09,141 --> 03:51:10,976
CANCER CARE BUT THE SCOPE OF

6331
03:51:10,976 --> 03:51:12,144
THESE WOULD OBVIOUSLY FALL

6332
03:51:12,144 --> 03:51:17,816
WITHIN BEHAVIORIAL AND

6333
03:51:17,816 --> 03:51:18,383
COMMUNICATION ORIENTED

6334
03:51:18,383 --> 03:51:19,585
INTERVENTIONS.

6335
03:51:19,585 --> 03:51:23,522
NARE THERE ANY OTHER SALIENT

6336
03:51:23,522 --> 03:51:23,789
COMMENTS?

6337
03:51:23,789 --> 03:51:24,189
YES IN.

6338
03:51:24,189 --> 03:51:25,390
>> THANK YOU SO MUCH
ROBIN.

6339
03:51:25,390 --> 03:51:27,092
GOOD TO SEE YOU, WONDERFUL

6340
03:51:27,092 --> 03:51:28,560
PRESENTATION AND I WAS VERY

6341
03:51:28,560 --> 03:51:29,928
STRUCK BY THE DEFINITION OF

6342
03:51:29,928 --> 03:51:31,463
STIGMA BECAUSE I DON'T KNOW I'VE

6343
03:51:31,463 --> 03:51:32,931
EVER THOUGHT ABOUT IT THAT WAY

6344
03:51:32,931 --> 03:51:36,034
SO I'M TBLAD YOU TALKED ABOUT

6345
03:51:36,034 --> 03:51:37,336
IRPT SECTIONALLITY BECAUSE

6346
03:51:37,336 --> 03:51:41,473
STIGMA BEING BE BLACK SKIN, IT

6347
03:51:41,473 --> 03:51:43,509
COULD BE IMMIGRATION STATUS OR

6348
03:51:43,509 --> 03:51:44,209
INCARCERATION STATUS SO THERE

6349
03:51:44,209 --> 03:51:47,679
COULD BE ALL OF THOSE SO TEASING

6350
03:51:47,679 --> 03:51:48,881
OUT THE INTERSECTIONALITY WILL

6351
03:51:48,881 --> 03:51:49,948
BE REALLY INTERESTING TO SEE

6352
03:51:49,948 --> 03:51:51,250
WHAT TECHNIQUES ARE USED FOR

6353
03:51:51,250 --> 03:51:52,518
THAT AND THEN JUST FOR

6354
03:51:52,518 --> 03:51:55,821
CLARIFICATION, DO YOU KNOW WHAT

6355
03:51:55,821 --> 03:51:58,891
THE PREVALENCE OF CANCER IS IN

6356
03:51:58,891 --> 03:52:00,092
INDIVIDUALS WITH HIV BOTH IN THE

6357
03:52:00,092 --> 03:52:02,561
U.S. AND THEN MORE BROADLY?

6358
03:52:02,561 --> 03:52:04,196
>> GREAT QUESTION.

6359
03:52:04,196 --> 03:52:06,265
IN THE UNITED STATES FOR 2020

6360
03:52:06,265 --> 03:52:10,169
THERE ARE ESTIMATED ABOUT 8000

6361
03:52:10,169 --> 03:52:15,174
CASES OF HIV AND CANCER AND

6362
03:52:15,174 --> 03:52:16,575
WHAT'S BEEN INTERESTING ABOUT

6363
03:52:16,575 --> 03:52:18,076
THE PATTERN OF CANCER AND HIV IN

6364
03:52:18,076 --> 03:52:21,146
THE U.S., FOR EXAMPLE IN 2010

6365
03:52:21,146 --> 03:52:25,417
THE LEADING CAUSES WERE

6366
03:52:25,417 --> 03:52:26,919
CARPOSI'S SARCOMA AND

6367
03:52:26,919 --> 03:52:28,187
NONHODGKINS LYMPHOMA BUT 2030 IT

6368
03:52:28,187 --> 03:52:29,788
WILL TRANSITION TO PROSTATE,

6369
03:52:29,788 --> 03:52:30,989
LUNG AND LIVER WHICH GOES BACK

6370
03:52:30,989 --> 03:52:33,425
ALSO TO THE CANCER IN AGING AND

6371
03:52:33,425 --> 03:52:34,726
LONGER LIFE EXPECTANCY SO

6372
03:52:34,726 --> 03:52:35,327
THERE'S DIFFERENT PATTERNS

6373
03:52:35,327 --> 03:52:36,261
WITHIN THE UNITED STATES AND

6374
03:52:36,261 --> 03:52:38,497
THEN IF YOU GO GLOBALLY TO YOUR

6375
03:52:38,497 --> 03:52:40,866
NEXT PART OFIOURE QUESTION, THAT

6376
03:52:40,866 --> 03:52:42,301
IS A LITTLE BIT MORE OF A

6377
03:52:42,301 --> 03:52:44,169
CHALLENGE TO COME UP WITH GLOBAL

6378
03:52:44,169 --> 03:52:46,738
ESTIMATES DUE TO CANCER

6379
03:52:46,738 --> 03:52:47,239
SURVEILLANCE CHALLENGES,

6380
03:52:47,239 --> 03:52:49,975
HOWEVER, WE DO FOR EXAMPLE, WITH

6381
03:52:49,975 --> 03:52:51,677
SERVAL CANCER AND HIV, CAN

6382
03:52:51,677 --> 03:52:56,715
OCCURRENCE AND AS WELL AS

6383
03:52:56,715 --> 03:52:59,818
CARPOSI'S SARCOMA IN HIV,

6384
03:52:59,818 --> 03:53:00,519
PREVALENCE, IT'S PRIMARILY

6385
03:53:00,519 --> 03:53:02,721
CONCENTRATE INDEED EASTERN AND

6386
03:53:02,721 --> 03:53:03,989
SOUTHERN AFRICA, BUT THERE ARE

6387
03:53:03,989 --> 03:53:05,757
ALSO OTHER, YOU KNOW WHAT I

6388
03:53:05,757 --> 03:53:07,492
MIGHT ELEVATED REAMIONS FOR

6389
03:53:07,492 --> 03:53:13,932
EXAMPLE, IN SOUTHEAST ASIA, WITH

6390
03:53:13,932 --> 03:53:15,100
CANCER AND HIV.

6391
03:53:15,100 --> 03:53:15,901
>> OTHER COMMENTS?

6392
03:53:15,901 --> 03:53:20,405
HERE, HERE, AND THERE?

6393
03:53:20,405 --> 03:53:20,639
QUICKLY.

6394
03:53:20,639 --> 03:53:23,742
>> SO THANK YOU FOR THE

6395
03:53:23,742 --> 03:53:24,076
PRESENTATION.

6396
03:53:24,076 --> 03:53:26,078
I'M WONDERING IF THE--I'M

6397
03:53:26,078 --> 03:53:30,482
CONFUSED SO HELP ME CLARIFY, I'M

6398
03:53:30,482 --> 03:53:32,517
WONDERING IF THE OPPORTUNITY

6399
03:53:32,517 --> 03:53:37,823
HERE IS AND THE PLAN IS THORS

6400
03:53:37,823 --> 03:53:39,124
ALSO, YOU MENTIONED THAT YOU'RE

6401
03:53:39,124 --> 03:53:41,426
PLANNING TO UNDERSTAND THE

6402
03:53:41,426 --> 03:53:43,128
SOURCES OF STIGMA, AND ALSO

6403
03:53:43,128 --> 03:53:45,430
GOING TO UNDERSTAND THE SOURCES

6404
03:53:45,430 --> 03:53:46,999
INDEPENDENT OF STIGMA, THAT ARE

6405
03:53:46,999 --> 03:53:51,670
RELEVANT TO THE POOR OUTCOMES IN

6406
03:53:51,670 --> 03:53:55,540
THIS POPULATION, SO I'M THINKING

6407
03:53:55,540 --> 03:53:56,842
FOR INSTANCE, WELL THE

6408
03:53:56,842 --> 03:53:59,778
UNDERLYING PROBLEM I HAVE IS

6409
03:53:59,778 --> 03:54:03,215
THAT HIV, JUST ANY DIAGNOSIS OF

6410
03:54:03,215 --> 03:54:05,417
HIV PAST OR PRESENT OFTEN

6411
03:54:05,417 --> 03:54:08,553
REMAINS AN EXCLUSION CRITERIA IN

6412
03:54:08,553 --> 03:54:10,322
THE INDUSTRY TRIALS AND NOT SO

6413
03:54:10,322 --> 03:54:12,858
MUCH IN NKRRK I TRIALS BUT IN

6414
03:54:12,858 --> 03:54:14,293
TREY TRIAL ANDS I THINK A LOT OF

6415
03:54:14,293 --> 03:54:18,930
HA IS A MISUNDERSTANDING OF WHAT

6416
03:54:18,930 --> 03:54:21,600
THE PROGNOSTIC OUTCOMES ARE AND

6417
03:54:21,600 --> 03:54:23,235
HOW TO BEST UNDERSTAND THESE.

6418
03:54:23,235 --> 03:54:30,642
AND LIKE FOR LYMPHOMAS IS IT

6419
03:54:30,642 --> 03:54:32,177
BECAUSE FOR EXAMPLE, IT'S

6420
03:54:32,177 --> 03:54:33,612
THEY'RE DIAGNOSED LATER IN TERMS

6421
03:54:33,612 --> 03:54:34,680
OF GETTING CLINICAL CARE,

6422
03:54:34,680 --> 03:54:35,881
GETTING THE DIAGNOSIS AND YOU

6423
03:54:35,881 --> 03:54:37,482
HAVE HIGHER BURDEN OF DISEASE,

6424
03:54:37,482 --> 03:54:39,651
HIGH BURDEN OF DEC DOESN'T WORK

6425
03:54:39,651 --> 03:54:41,887
SO WELL WITH CELL THERAPIES FOR

6426
03:54:41,887 --> 03:54:43,188
LYMPHOMA, SO IT'S NOT REALLY THE

6427
03:54:43,188 --> 03:54:45,424
HIV, IT'S THE HIGH BURDEN OF

6428
03:54:45,424 --> 03:54:46,925
DISEASE EMPLOY THAT'S THE KIND

6429
03:54:46,925 --> 03:54:48,927
OF THING I'M TALKING ABOUT, WE

6430
03:54:48,927 --> 03:54:51,430
REALLY UNDERSTAND THE CO FACTORS

6431
03:54:51,430 --> 03:54:54,066
THAT ARE RELEVANT AND DIFFERENT

6432
03:54:54,066 --> 03:54:55,934
THAN THE STIGMA, IT MAY BE

6433
03:54:55,934 --> 03:54:57,102
INFORMATIVE TO ALLOW MORE

6434
03:54:57,102 --> 03:55:01,173
PATIENTS IN TO INDUSTRY TRIALS.

6435
03:55:01,173 --> 03:55:06,611
NWE WILL NEED TO MOVE ALONG

6436
03:55:06,611 --> 03:55:07,746
MORE.

6437
03:55:07,746 --> 03:55:09,047
QUESTIONS COMMENTS?

6438
03:55:09,047 --> 03:55:13,285
NROBIN, GREAT PRESENT ATION, YOU

6439
03:55:13,285 --> 03:55:15,354
MENTIONED IF THIS MOVES FORWARD,

6440
03:55:15,354 --> 03:55:17,823
THE POTENTIAL SORT OF

6441
03:55:17,823 --> 03:55:18,890
RECRUITMENT, YOU KNOW PEOPLE WHO

6442
03:55:18,890 --> 03:55:21,326
WOULD BE INTEREST AND I JUST--IT

6443
03:55:21,326 --> 03:55:22,761
STRUCK ME THE TIMING IS GREAT,

6444
03:55:22,761 --> 03:55:25,630
BECAUSE OF ALL THE SUPPLEMENTS

6445
03:55:25,630 --> 03:55:28,200
THAT NCI HAS DONE AROUND THIS

6446
03:55:28,200 --> 03:55:30,369
TOPIC, THE D40S FOR

6447
03:55:30,369 --> 03:55:31,203
INTERNATIONALLY, AND SO, I JUST

6448
03:55:31,203 --> 03:55:32,738
WANT TO MAKE SURE THAT YOU KNOW

6449
03:55:32,738 --> 03:55:34,172
YOU PROBABLY GOT THAT ON YOUR

6450
03:55:34,172 --> 03:55:35,774
LIST BUT THERE'S REALLY A NICE

6451
03:55:35,774 --> 03:55:39,978
CADRE OF PEOPLE WHO WOULD BE

6452
03:55:39,978 --> 03:55:41,012
WELL POSITIONED, BUT MAYBE

6453
03:55:41,012 --> 03:55:42,948
10IERS AGO THAT WASN'T THE CASE

6454
03:55:42,948 --> 03:55:43,248
NABSOLUTELY.

6455
03:55:43,248 --> 03:55:46,318
WE THANK YOU TO CGH FOR OFFERING

6456
03:55:46,318 --> 03:55:48,320
THOSE ADMINISTRATIVE SUPLEMS FOR

6457
03:55:48,320 --> 03:55:49,321
2 FISCAL YEARS.

6458
03:55:49,321 --> 03:55:51,957
WE ALSO HOSTED A GLOBAL CANCER

6459
03:55:51,957 --> 03:55:54,126
STIGMA CONFERENCE IN NOVEMBER OF

6460
03:55:54,126 --> 03:55:55,660
2022 WITH OVER A HUNDRED FOLKS

6461
03:55:55,660 --> 03:55:57,362
FROM AROUND THE WORLD.

6462
03:55:57,362 --> 03:55:59,698
AND WE ALSO HAVE BEEN IN CONTACT

6463
03:55:59,698 --> 03:56:01,900
OBVIOUSLY WITH OUR FOGARTY

6464
03:56:01,900 --> 03:56:04,970
COLLEAGUES AND OUR NIMH

6465
03:56:04,970 --> 03:56:08,240
COLLEAGUES WHO WORK IN THE HIV

6466
03:56:08,240 --> 03:56:08,807
SPACE AS WELL.

6467
03:56:08,807 --> 03:56:14,846
SO WE REALLY ARE WELL POISED TO

6468
03:56:14,846 --> 03:56:15,414
PROMOTE THIS OPPORTUNITY.

6469
03:56:15,414 --> 03:56:25,524
>> CAN I HAVE A MOTION?

6470
03:56:25,524 --> 03:56:26,191
SECOND.

6471
03:56:26,191 --> 03:56:26,525
>> SECOND.

6472
03:56:26,525 --> 03:56:28,727
>> IS THERE ANY FURTHER

6473
03:56:28,727 --> 03:56:29,060
DISCUSSION?

6474
03:56:29,060 --> 03:56:34,833
IF NOT, ARE THERE ANY NAY VOTES?

6475
03:56:34,833 --> 03:56:40,605
ARE THERE ANY ABSTENTIONS?

6476
03:56:40,605 --> 03:56:41,239
AUTOUNANIMOUS, OKAY, THANK YOU

6477
03:56:41,239 --> 03:56:41,740
VERY MUCH ROBIN.

6478
03:56:41,740 --> 03:56:43,341
NOW WE WILL MOVE ON TO THE NEXT

6479
03:56:43,341 --> 03:56:45,577
CONCEPT WHICH IS SCALING UP AND

6480
03:56:45,577 --> 03:56:47,279
MAINTAINING EVIDENT BASED

6481
03:56:47,279 --> 03:56:50,849
INTERVENTIONS TO MAXIMIZE IMPACT

6482
03:56:50,849 --> 03:56:54,519
ON CANCER CONCEPT SUMMIT.

6483
03:56:54,519 --> 03:56:55,387
DR. DAVID CHAMBERS.

6484
03:56:55,387 --> 03:56:55,787
>> YES, GREAT.

6485
03:56:55,787 --> 03:56:58,089
THIS IS STILL ON, DIDN'T FALL

6486
03:56:58,089 --> 03:56:59,458
ARK SLEEP.

6487
03:56:59,458 --> 03:57:01,026
AND OUR COMMITTEE IS FLORRIA,

6488
03:57:01,026 --> 03:57:02,227
MARK AND LISA.

6489
03:57:02,227 --> 03:57:03,228
PLEASE GO AHEAD?

6490
03:57:03,228 --> 03:57:04,763
SO GOOD AFTERNOON, EVERYBODY I'M

6491
03:57:04,763 --> 03:57:06,731
VERY PLEASED TO BE ABLE TO

6492
03:57:06,731 --> 03:57:09,968
REPRESENT THIS SUMMIT RFA, 1 OF

6493
03:57:09,968 --> 03:57:12,070
MY ACRONYMS, SUMMIT IS ON BEHALF

6494
03:57:12,070 --> 03:57:14,773
OF THE WONDERFUL DCCPS TEAM, THE

6495
03:57:14,773 --> 03:57:16,174
GOALS OF THIS INITIATIVE ARE 3

6496
03:57:16,174 --> 03:57:17,843
FOLD, WHAT WE WANT TO DO IS TRY

6497
03:57:17,843 --> 03:57:19,444
AND BUILD A KNOWLEDGE BASE FOR

6498
03:57:19,444 --> 03:57:21,079
HOW WE BRING EVIDENT BASED

6499
03:57:21,079 --> 03:57:22,514
CANCER INTERVENTIONS TO SCALE,

6500
03:57:22,514 --> 03:57:24,549
AND MAKE SURE THAT THEY'RE

6501
03:57:24,549 --> 03:57:25,917
SUSTAINED, THEIR WIDE SPREAD USE

6502
03:57:25,917 --> 03:57:26,885
IS SUSTAINED OVER TIME AT THE

6503
03:57:26,885 --> 03:57:30,789
SAME TIME WE WANT TO DIRECTLY

6504
03:57:30,789 --> 03:57:33,325
IMPACT STANDARD OF CARE FOR 2

6505
03:57:33,325 --> 03:57:35,760
TOBACCO RELATED AREAS WHERE WE

6506
03:57:35,760 --> 03:57:36,962
KNOW REDUCED UPTAKE CAN REDUCE

6507
03:57:36,962 --> 03:57:40,131
MORTALITY AND WE WANT TO EXTEND

6508
03:57:40,131 --> 03:57:40,966
THIS GENERALIZABLE KNOWLEDGE TO

6509
03:57:40,966 --> 03:57:47,939
SCALE UP AND SUSTAIN OTHER TYPES

6510
03:57:47,939 --> 03:57:49,441
OF INTERVENTIONS EMPLOY AND

6511
03:57:49,441 --> 03:57:52,377
SCIENCES AND INFO GRAPHIC COMES

6512
03:57:52,377 --> 03:57:54,279
FROM THE PLAN FROM TWEBT 21 AND

6513
03:57:54,279 --> 03:57:55,780
REALLY ECHICIZING THAT THE

6514
03:57:55,780 --> 03:57:58,517
SCIENTIFIC FOCUS IS TO MAKE SURE

6515
03:57:58,517 --> 03:58:00,218
ABOUT HOW WE BRING THESE

6516
03:58:00,218 --> 03:58:01,286
INTERVENTIONS TO THE DIFFERENT

6517
03:58:01,286 --> 03:58:03,922
CARE SYSTEMS IN WHICH PEOPLE ARE

6518
03:58:03,922 --> 03:58:05,590
SEEING TO OPTIMIZE CARE AND SEE

6519
03:58:05,590 --> 03:58:06,791
GAINSA THE POPULATION LEVEL IN

6520
03:58:06,791 --> 03:58:11,663
SURVIVAL AND QUALITY OF LIFE AND

6521
03:58:11,663 --> 03:58:11,897
EQUITY.

6522
03:58:11,897 --> 03:58:13,665
AND NOW NOW THROUGH HAD MOON

6523
03:58:13,665 --> 03:58:15,166
SHOT AND OTHER INITTIAIVE ITS WE

6524
03:58:15,166 --> 03:58:17,369
HAVE BEEN ABLE TO BUILD THE

6525
03:58:17,369 --> 03:58:19,004
FIELD IN CAPACITY AND CANCER

6526
03:58:19,004 --> 03:58:19,938
CONTROL INTERVENTION AREAS THAT

6527
03:58:19,938 --> 03:58:22,607
WE FEEL GET US READY TO TRY TO

6528
03:58:22,607 --> 03:58:24,109
REACH THE SUMMIT, TO THINK ABOUT

6529
03:58:24,109 --> 03:58:26,945
HOW WE CAN SCALE UP AND SUSTAIN

6530
03:58:26,945 --> 03:58:29,781
THESE INTERVENTIONS AT A MUCH

6531
03:58:29,781 --> 03:58:30,248
LARGER DEGREE.

6532
03:58:30,248 --> 03:58:32,684
SO THERE ARE MANY AREAS IN WHICH

6533
03:58:32,684 --> 03:58:34,519
WE CAN ENVISION THE NEED FOR

6534
03:58:34,519 --> 03:58:35,921
SCALE UP AND CONTINUEMENT BUT WE

6535
03:58:35,921 --> 03:58:37,689
WANTED TO TART WITH THE MOON

6536
03:58:37,689 --> 03:58:38,657
SHOT AND NATIONAL CANCER PLAN

6537
03:58:38,657 --> 03:58:40,725
GOALS OF TRYING TO REDUCE

6538
03:58:40,725 --> 03:58:42,494
MORTALITY BY 50% OVER 25 YEARS

6539
03:58:42,494 --> 03:58:45,330
AND THAT SUGGIESTS TO US THAT

6540
03:58:45,330 --> 03:58:47,198
TOBACCO RELATED CARE CONTINUES

6541
03:58:47,198 --> 03:58:48,800
TO PROVIDE EXAMPLES WHERE SCALE

6542
03:58:48,800 --> 03:58:50,435
UP AND SUSTAINMENT CAN TRANSLATE

6543
03:58:50,435 --> 03:58:51,970
BO THOSE REDUCTIONS IN MORTALITY

6544
03:58:51,970 --> 03:58:53,538
AND ON THE LEFT YOU SEE LUNG

6545
03:58:53,538 --> 03:58:55,273
CANCER SCREENING AND YOU SEE THE

6546
03:58:55,273 --> 03:58:55,974
TASK FORCE RECOMMENDATION AND

6547
03:58:55,974 --> 03:58:59,611
YET WE KNOW THAT UPTAKE MAY BE

6548
03:58:59,611 --> 03:59:01,913
AS LITTLE AS 4 PERCENT OR UP TO

6549
03:59:01,913 --> 03:59:04,282
28%, THERE WAS A PAPER UP TO 2

6550
03:59:04,282 --> 03:59:06,985
YEARS AGO THAT ESTIMATE THE

6551
03:59:06,985 --> 03:59:09,154
LEVEL OF UPTAKE AT 22 FROM THE

6552
03:59:09,154 --> 03:59:11,022
POPULATION, FROM OUR MODELERS WE

6553
03:59:11,022 --> 03:59:12,223
KNOW WE CAN SAVE THOUSANDS OF

6554
03:59:12,223 --> 03:59:14,459
LIVES IF WE CAN DRAMATICALLY

6555
03:59:14,459 --> 03:59:15,760
INCREASE KREENING RATES, IT

6556
03:59:15,760 --> 03:59:17,028
SEEMS LIKE SOMETHING WE NEED TO

6557
03:59:17,028 --> 03:59:18,897
SCALE UP AND SUSTAIN AS SOON AS

6558
03:59:18,897 --> 03:59:19,464
WE CAN.

6559
03:59:19,464 --> 03:59:23,335
WE ALSO HAVE EVIDENCE-BASED

6560
03:59:23,335 --> 03:59:25,203
INNERVENTIONS FOR TOBACCO

6561
03:59:25,203 --> 03:59:26,972
CESSATION, TOBACCO USE TREATMENT

6562
03:59:26,972 --> 03:59:27,639
AMONG CANCER SURVIVORS, SOME

6563
03:59:27,639 --> 03:59:30,542
FACT WOE HAD A MOON SHOT INIT

6564
03:59:30,542 --> 03:59:31,576
WHYATIVE, WHERE OVER 50

6565
03:59:31,576 --> 03:59:35,180
DIFFERENT EXAMPLES OF TRYING TO

6566
03:59:35,180 --> 03:59:37,215
LOCALLY IMPLEMENT EVIDENT BASED

6567
03:59:37,215 --> 03:59:41,019
TOBACCO USE TREATMENT FOR CANCER

6568
03:59:41,019 --> 03:59:41,753
PATIENTS WERE ATTEMPTED.

6569
03:59:41,753 --> 03:59:43,254
AT THE SAME TIME WE KNOW THERE'S

6570
03:59:43,254 --> 03:59:44,422
2 MILLION PEOPLE AT LEAST WHO

6571
03:59:44,422 --> 03:59:45,724
ARE SMOKERS AND WE KNOW THAT

6572
03:59:45,724 --> 03:59:47,258
SMOKING FOR THOSE WHO HAVE BEEN

6573
03:59:47,258 --> 03:59:50,428
DIAGNOSED AND ARE RECEIVING

6574
03:59:50,428 --> 03:59:52,163
TREATMENT FOR CANCER IS REDUCING

6575
03:59:52,163 --> 03:59:53,431
SURVIVAL AND SO AGAIN AN AREA

6576
03:59:53,431 --> 03:59:55,300
WHERE WE ARE RELATIVELY LOW

6577
03:59:55,300 --> 03:59:56,601
UPTAKE, IT'S NOT A STANDARD PART

6578
03:59:56,601 --> 03:59:58,336
OF CARE THAT WE BELIEVE THAT IT

6579
03:59:58,336 --> 04:00:00,538
CAN BE AND SO SCALE UP AND

6580
04:00:00,538 --> 04:00:02,607
CONTINUEMENT TRIALS COULD BE

6581
04:00:02,607 --> 04:00:04,242
INKRED BELIEVELY HELPFUL SO THE

6582
04:00:04,242 --> 04:00:06,111
SUMMIT STRUCTURE MAPS ON TO

6583
04:00:06,111 --> 04:00:07,879
THOSE 2 CHALLENGES, 2 DIFFERENT

6584
04:00:07,879 --> 04:00:09,748
RFAs, BOTH OF WHICH ARE REALLY

6585
04:00:09,748 --> 04:00:11,249
CONCENTRATING ON SYSTEM LEVEL

6586
04:00:11,249 --> 04:00:12,817
TRAT EDGYS TO KALE UP AND

6587
04:00:12,817 --> 04:00:13,985
SUSTAIN THESE RESPECTIVE

6588
04:00:13,985 --> 04:00:15,353
INTERVENTIONS WITHIN HEALTHCARE

6589
04:00:15,353 --> 04:00:16,921
CLINICS, WE SEE IMRAIT

6590
04:00:16,921 --> 04:00:18,289
OPPORTUNITY FOR COLLABORATION

6591
04:00:18,289 --> 04:00:19,724
ACROSS THE STUDIES, GIVEN THEY

6592
04:00:19,724 --> 04:00:20,759
SHARE RESEARCH QUESTIONS, TYPES

6593
04:00:20,759 --> 04:00:22,494
OF SETTINGS AND THE STRATEGIES

6594
04:00:22,494 --> 04:00:24,029
THAT CAN SUPPORT SCALE UP AND

6595
04:00:24,029 --> 04:00:25,563
SUSTAINMENT AND WE'VE TAKEN THE

6596
04:00:25,563 --> 04:00:26,297
APPROACH TO COORDINATION FROM

6597
04:00:26,297 --> 04:00:27,699
SOME OF THE OTHER INITIATIVES

6598
04:00:27,699 --> 04:00:29,234
THAT WE'VE BEEN ENGAGED IN, THE

6599
04:00:29,234 --> 04:00:32,070
IDEA OF A STEERING COMMITTEE AND

6600
04:00:32,070 --> 04:00:33,972
SOMATIC WORKING GROUPS.

6601
04:00:33,972 --> 04:00:35,006
WE ANTICIPATE COORDINATION

6602
04:00:35,006 --> 04:00:37,342
AROUND COMMON MEASURES, RESEARCH

6603
04:00:37,342 --> 04:00:39,044
DESIGNS, POOLING DATA ELEMENTS

6604
04:00:39,044 --> 04:00:40,812
THAT MIGHT PERMIT CROSS TRIAL

6605
04:00:40,812 --> 04:00:49,454
ANALYSIS, WE SEE ACTING AS THE

6606
04:00:49,454 --> 04:00:53,591
SHERPA, AND WE'VE INN ENGAGED IN

6607
04:00:53,591 --> 04:00:54,626
THE RAGMATIC TRIALS LABORATORY

6608
04:00:54,626 --> 04:00:56,428
THAT OVERSEES A LOT OF PRAGMATIC

6609
04:00:56,428 --> 04:00:58,296
TRIAL ANDS SYSTEMS AND THEY'RE

6610
04:00:58,296 --> 04:00:58,863
MOVING INTO IMPLEMENTATION

6611
04:00:58,863 --> 04:00:59,731
SCIENCE AND WE THINK IT'S A

6612
04:00:59,731 --> 04:01:01,466
BEAUTIFUL FIT TO HELP TO TAKE

6613
04:01:01,466 --> 04:01:08,006
ADVANTAGE OF A LEARNINGS ACROSS

6614
04:01:08,006 --> 04:01:09,274
THESE DIFFERENT STUDIES.

6615
04:01:09,274 --> 04:01:10,108
SO CONCEPTUALLY YOU WILL SEE THE

6616
04:01:10,108 --> 04:01:12,210
CORE OF ALL OF THESE IN THE

6617
04:01:12,210 --> 04:01:12,811
MIDDLE.

6618
04:01:12,811 --> 04:01:15,814
IT'S THE TYPE OF SUPPORTING KALE

6619
04:01:15,814 --> 04:01:17,682
AND SUSTAINMENT, AND THE KINDS

6620
04:01:17,682 --> 04:01:18,983
OF STRATEGIES WE THINK WOULD BE

6621
04:01:18,983 --> 04:01:19,984
RIGHT FOR TESTING, THE SEE THEA

6622
04:01:19,984 --> 04:01:21,286
THE BOTTOM THE TYPES OF SETTINGS

6623
04:01:21,286 --> 04:01:24,489
WE LIKE TO SEE THESE TRIALS

6624
04:01:24,489 --> 04:01:26,791
LOCATED IN A MINIMUM NUMBER OF

6625
04:01:26,791 --> 04:01:28,727
60 SITES PER TRIAL WHICH SOME

6626
04:01:28,727 --> 04:01:29,994
MAY THINK ARE AMBITIOUS BUT

6627
04:01:29,994 --> 04:01:31,663
THAT'S THE WAY WE BELIEVE WE CAN

6628
04:01:31,663 --> 04:01:33,064
GET TO POPULATION LEVEL IMPACT,

6629
04:01:33,064 --> 04:01:36,835
THAT THAT NUMBER OF SITES

6630
04:01:36,835 --> 04:01:37,535
TRANSLATES INTO THOUSANDS OF

6631
04:01:37,535 --> 04:01:39,070
PATIENTS THAT WE CAN WORK WITH,

6632
04:01:39,070 --> 04:01:41,806
WITH THIS IDEA THAT EQUITABLE

6633
04:01:41,806 --> 04:01:42,440
IMPLEMENTATION IS THE SUCCESS

6634
04:01:42,440 --> 04:01:44,709
THAT WE WANT TO HAVE.

6635
04:01:44,709 --> 04:01:46,111
THREE TRIALS WE WANT ANTICIPATE

6636
04:01:46,111 --> 04:01:47,145
HOPEFULLY BEING ABLE TO SUPPORT

6637
04:01:47,145 --> 04:01:49,080
FOR EACH OF THESE RFAs.

6638
04:01:49,080 --> 04:01:50,548
SO JUST TO GIVE YOU AN EXAMPLE

6639
04:01:50,548 --> 04:01:52,217
OF THE STUDY, WE CAN ENVISION A

6640
04:01:52,217 --> 04:01:54,886
RESPONSE SAY TO THE LUNG CANCER

6641
04:01:54,886 --> 04:01:56,521
SCREENING RFA, PROPOSING A

6642
04:01:56,521 --> 04:01:57,455
CLUSTER RANDOMIZED CONTROL TRIAL

6643
04:01:57,455 --> 04:01:59,090
ACROSS A HELPED FEDERALLY

6644
04:01:59,090 --> 04:02:00,725
QUALIFIED HEALTH CENTER CLINICS,

6645
04:02:00,725 --> 04:02:03,161
CAN YOU IMAGINE THE TRIAL DOING

6646
04:02:03,161 --> 04:02:04,229
A COMPARATIVE EFFECT OF THE

6647
04:02:04,229 --> 04:02:05,363
STUDY OF DEFINITE APPROACHES, 1

6648
04:02:05,363 --> 04:02:07,866
MIGHT BE A CLINIC CENTRIC

6649
04:02:07,866 --> 04:02:09,033
PRACTICE FACILITATION MODEL AS

6650
04:02:09,033 --> 04:02:10,535
WELL AS FOCUSING ON FINANCING OF

6651
04:02:10,535 --> 04:02:12,303
THE 8 DIFFERENT COMPONENTS OF

6652
04:02:12,303 --> 04:02:16,074
EVIDENCE BASED LUNG CANCER

6653
04:02:16,074 --> 04:02:18,009
KREENING, YOU MIGHT COMPARE THAT

6654
04:02:18,009 --> 04:02:20,445
WITH A COMMUNITY OF PRACTICE

6655
04:02:20,445 --> 04:02:22,380
SCALING UP SITES, AND IT

6656
04:02:22,380 --> 04:02:24,082
MENTIONED BEFORE PROJECT OAK E

6657
04:02:24,082 --> 04:02:25,483
AND OTHERS THOAT MIGHT BE

6658
04:02:25,483 --> 04:02:26,851
HELPFULFUL TO DEVELOP EVIDENT AS

6659
04:02:26,851 --> 04:02:29,320
HOW THEY DEVELOP SCALE UP AND

6660
04:02:29,320 --> 04:02:30,021
SUSTAINMENT, THE OUTCOME IS

6661
04:02:30,021 --> 04:02:31,790
WHETHER THEY GET TO CARE AND NOT

6662
04:02:31,790 --> 04:02:37,295
JUST INITIALLY BUT WHETHER

6663
04:02:37,295 --> 04:02:38,496
THATTHODE IMPROVED OVER TIME AND

6664
04:02:38,496 --> 04:02:40,231
THAT'S WHY YOU CAN SEE FOR

6665
04:02:40,231 --> 04:02:44,235
EXAMPLE, THE 12, 18 AND 24 MONTH

6666
04:02:44,235 --> 04:02:44,636
OUTCOMES.

6667
04:02:44,636 --> 04:02:47,238
SO WE PROPOSE TO FOLLOW UP PAST

6668
04:02:47,238 --> 04:02:48,473
INITCRATIVES THAT WE'VE DONE

6669
04:02:48,473 --> 04:02:51,342
THAT HAVE DONE THIS UHG3

6670
04:02:51,342 --> 04:02:53,878
MECHANISM, WE HAVE DONE THIS IN

6671
04:02:53,878 --> 04:02:55,847
COMMON FUND AND MOON SHOT

6672
04:02:55,847 --> 04:02:57,248
INITTIAIVE ITS, IT WOULD OFFER 2

6673
04:02:57,248 --> 04:02:59,117
YEARS TO SUPPORT THE PREPATTORY

6674
04:02:59,117 --> 04:03:00,218
ACTIVITIES FOR EACH OF THE

6675
04:03:00,218 --> 04:03:02,520
TRIALS AND CLEAR MILE TONES TO

6676
04:03:02,520 --> 04:03:05,590
DETERMINE WHETHER AND NOT A FATE

6677
04:03:05,590 --> 04:03:07,559
COMPLETE, WHETHER THESE TRIALS

6678
04:03:07,559 --> 04:03:09,327
ARE FEASIBLE TO COMPLETE MOVING

6679
04:03:09,327 --> 04:03:10,862
FORWARD AND NCI ADMINISTRATIVE

6680
04:03:10,862 --> 04:03:13,164
REVIEW TO DETERMINE HAVE THEY

6681
04:03:13,164 --> 04:03:14,566
MET THOSE BENCHMARKS, ARE THEY

6682
04:03:14,566 --> 04:03:16,568
READY TO BE LAUNCHED IN DO THEY

6683
04:03:16,568 --> 04:03:17,969
HAVE THE SITES AVAILABLE TO

6684
04:03:17,969 --> 04:03:19,704
CONDUCT THE TODAY AND ONLY THEN

6685
04:03:19,704 --> 04:03:22,907
WOULD MAY HIEWF ON TO THE UH

6686
04:03:22,907 --> 04:03:24,008
IMPLEMENTATION 3 PHASE, TO

6687
04:03:24,008 --> 04:03:24,943
CONDUCT THE TRIAL.

6688
04:03:24,943 --> 04:03:26,411
SO THE PROPOSED BUDGET MAPS ON

6689
04:03:26,411 --> 04:03:28,613
TO THE FACES, YOU SEE A SMALLER

6690
04:03:28,613 --> 04:03:30,281
FOCUS FOR THE UG FACE IN TERMS

6691
04:03:30,281 --> 04:03:32,016
OF OVERALL BUNLET WITH

6692
04:03:32,016 --> 04:03:32,684
ANTICIPATED SUPPORT FROM

6693
04:03:32,684 --> 04:03:33,885
REMAINING MOON SHOT DOLLARS TO

6694
04:03:33,885 --> 04:03:35,620
FUND THE BALANCE OF THIS

6695
04:03:35,620 --> 04:03:36,688
RESEARCH PROGECS.

6696
04:03:36,688 --> 04:03:46,631
THE UH 3 PHASE, THE BUNLET PER

6697
04:03:46,631 --> 04:03:48,266
YEAR MAPS RELATIVELY CLOSER TO

6698
04:03:48,266 --> 04:03:50,835
STYLES, AND NOT ALL PROJECTS

6699
04:03:50,835 --> 04:03:53,538
WILL GRADUATE TO THE UH3, SO

6700
04:03:53,538 --> 04:03:55,406
THIS MAY BE AN OVERESTIMATE OF

6701
04:03:55,406 --> 04:03:57,308
THE OVERALL PLAN OR BUDGET WITH

6702
04:03:57,308 --> 04:03:58,843
THE INITIATIVE BUT FOR THOSE 4

6703
04:03:58,843 --> 04:03:59,644
YEARS THOSE PRONG ECTOMYOSINS

6704
04:03:59,644 --> 04:04:02,247
THAT ARE DEEMED ABLE TO MOVE

6705
04:04:02,247 --> 04:04:05,583
FORWARD WOULD DO SO SO IN THE

6706
04:04:05,583 --> 04:04:06,517
SHORT-TERM, THE EVALUATION

6707
04:04:06,517 --> 04:04:07,719
CRITERIA, THE WAY WE MEASURE

6708
04:04:07,719 --> 04:04:08,953
SUCCESS REEL KEEPSAKESLY RELATED

6709
04:04:08,953 --> 04:04:10,421
TO THE DIFFERENT PHASES ARE WE

6710
04:04:10,421 --> 04:04:11,756
SEEING IN THE FITTER COUPLE

6711
04:04:11,756 --> 04:04:13,391
YEARS THE ACHEFMENT OF THE

6712
04:04:13,391 --> 04:04:13,691
MILESTONES.

6713
04:04:13,691 --> 04:04:16,928
ARE THEY COMPLOATING PREPATTORY

6714
04:04:16,928 --> 04:04:17,362
ACTIVITIES?

6715
04:04:17,362 --> 04:04:19,697
ARE THEY ENGAGE NOTHING AROUND

6716
04:04:19,697 --> 04:04:20,865
RESEARCH DEFINEMENT IN AROUND

6717
04:04:20,865 --> 04:04:24,836
COMMON MEASURES AND METRICS?

6718
04:04:24,836 --> 04:04:26,170
ARE THEY ACHIEVING THOSE AND IT

6719
04:04:26,170 --> 04:04:28,373
MAPS BACK TO THE PURPOSE, ARE WE

6720
04:04:28,373 --> 04:04:29,841
SEEING A GENERATED EVIDENT BASE

6721
04:04:29,841 --> 04:04:32,977
FOR HOW WE SCALE UP ON THESE

6722
04:04:32,977 --> 04:04:34,412
INTERVENTIONS, ARE WE SEEING THE

6723
04:04:34,412 --> 04:04:35,980
KNOCK ON BENEFIT IN TERPS OF

6724
04:04:35,980 --> 04:04:37,815
INCREASE OF THE USE OF DIFFERENT

6725
04:04:37,815 --> 04:04:38,983
ISHT VENTIONS OVER DISPIEM ARE

6726
04:04:38,983 --> 04:04:41,619
WE SEEING THIS CROSS LEARN XG

6727
04:04:41,619 --> 04:04:43,488
DOES IT EXTEND POTENTIALLY TO

6728
04:04:43,488 --> 04:04:45,123
OTHER AREAS WHERE WE KALE UP AND

6729
04:04:45,123 --> 04:04:46,491
DO EVIDENCE BASED CARE.

6730
04:04:46,491 --> 04:04:49,894
GREAT FEEDBACK AND CONVERSATION

6731
04:04:49,894 --> 04:04:53,231
WE HAD WITH OUR SUBCOMMITTEE BUT

6732
04:04:53,231 --> 04:04:54,766
THEY ENCOURAGED US TO MAKE SURE

6733
04:04:54,766 --> 04:04:56,134
THAT 60 SITES AS A THRESHOLD

6734
04:04:56,134 --> 04:04:59,003
DIDN'T MEAN THAT ONLY CERTAIN

6735
04:04:59,003 --> 04:05:00,939
SITES CAN PARTICIPATE, IT ONLY

6736
04:05:00,939 --> 04:05:01,873
FAVORS CERTAIN TYPES OF HELT

6737
04:05:01,873 --> 04:05:04,509
SYSTEMS AND WE NOTE THAT THE 2

6738
04:05:04,509 --> 04:05:07,178
YEAR UG3 PHASE IS INTENDED TO

6739
04:05:07,178 --> 04:05:08,212
SUPPORT BROADER SITE RECRUITMENT

6740
04:05:08,212 --> 04:05:10,348
AND THE LINK TO THE

6741
04:05:10,348 --> 04:05:11,182
COLLABORATORY, THE LINK TO

6742
04:05:11,182 --> 04:05:12,817
LEVERAGE SOME OF OUR EXISTS

6743
04:05:12,817 --> 04:05:14,218
NETWORKS WE THINK WILL MAKE IT

6744
04:05:14,218 --> 04:05:17,121
POSSIBLE FOR MORE SITES TO

6745
04:05:17,121 --> 04:05:19,424
PARTICIPATE, IT ENCOURAGES US TO

6746
04:05:19,424 --> 04:05:20,258
THINK EFFECTIVELY, WE MIGHT

6747
04:05:20,258 --> 04:05:22,527
MODEL WHAT WE'VE DONE IN OUR

6748
04:05:22,527 --> 04:05:23,394
IMPLEMENTATION SCIENCE CENTERS

6749
04:05:23,394 --> 04:05:25,330
AND CANCER CONTROL WHEN WE'VE

6750
04:05:25,330 --> 04:05:27,098
DONE THESE COLLABORATIVE

6751
04:05:27,098 --> 04:05:27,899
PROAJTS,A ROUND HEALTH EQUITY

6752
04:05:27,899 --> 04:05:30,268
AND WE MIGHT DO THINGS AROUND

6753
04:05:30,268 --> 04:05:31,636
SUPPLEMENTS AND USING

6754
04:05:31,636 --> 04:05:32,337
INFRASTRUCTURES AND WANTED TO

6755
04:05:32,337 --> 04:05:33,972
MAKE SURE WE DO USE THE

6756
04:05:33,972 --> 04:05:35,940
OPPORTUNITY TO INN COURAGE

6757
04:05:35,940 --> 04:05:37,108
MULTIPI GRANTS ACROSS

6758
04:05:37,108 --> 04:05:38,042
INSTITUTIONS, AT THE SAME TIME

6759
04:05:38,042 --> 04:05:41,045
WE DON'T WANT TO SEE ALL OF THE

6760
04:05:41,045 --> 04:05:42,113
PROGECS LOCATED WITHIN A VERY

6761
04:05:42,113 --> 04:05:43,881
SMALL SET OF INSTITUTIONS, SO WE

6762
04:05:43,881 --> 04:05:45,850
WANT TO LIMIT THE INSTITUTION

6763
04:05:45,850 --> 04:05:48,386
THAT CAN SERVE AS A PRIMARY

6764
04:05:48,386 --> 04:05:50,088
GRANT RECIPIENT FOR EACH TRIAL

6765
04:05:50,088 --> 04:05:53,858
TO JUST 1 APPLICATION FOR RPFA,

6766
04:05:53,858 --> 04:05:55,727
THEY GAVE US GREAT PEDE BACK ON

6767
04:05:55,727 --> 04:05:56,527
INCLUDING EARLY STAGE

6768
04:05:56,527 --> 04:05:58,496
INVESTIGATORS AND THEN WHILE WE

6769
04:05:58,496 --> 04:06:01,165
ARE FOCUSED ON GUIDE LINE

6770
04:06:01,165 --> 04:06:02,467
CONCORDANT CARE, THEY DID

6771
04:06:02,467 --> 04:06:04,068
ENCOURAGE US TO MAKE SURE THAT

6772
04:06:04,068 --> 04:06:05,236
THINKING ABOUT CERTAIN GROUPS

6773
04:06:05,236 --> 04:06:06,637
THAT MIGHT BENEFIT FROM THESE

6774
04:06:06,637 --> 04:06:08,172
INTERVENTIONS ARE NOT IGNORED

6775
04:06:08,172 --> 04:06:10,341
LIKE YOUNG ADULT CAPSER

6776
04:06:10,341 --> 04:06:11,342
SURVIVORS AND SAFETY NETSYSTEMS

6777
04:06:11,342 --> 04:06:13,177
SO WITH THAT I AM WANT TO SAY I

6778
04:06:13,177 --> 04:06:14,612
AM PRIVILEGED TO BE A--BITS TO

6779
04:06:14,612 --> 04:06:17,148
WORK WITH THIS INCREDIBLE WHO

6780
04:06:17,148 --> 04:06:18,249
DESERVES THE CREDIT FOR THE GOOD

6781
04:06:18,249 --> 04:06:24,055
THING ANDS I THANK YOU SO MUCH

6782
04:06:24,055 --> 04:06:24,522
FOR LISTENING.

6783
04:06:24,522 --> 04:06:29,861
>> THANK YOU.

6784
04:06:29,861 --> 04:06:30,094
GLORIA?

6785
04:06:30,094 --> 04:06:30,828
>> NICE PRESENTATION AND I
WANT

6786
04:06:30,828 --> 04:06:32,063
TO ACKNOWLEDGE THE OTHER MEMBERS

6787
04:06:32,063 --> 04:06:36,200
ON THE COMMITTEE, LISA AND MARK

6788
04:06:36,200 --> 04:06:39,771
AND I WELCOME THEIR CONTRIBUTION

6789
04:06:39,771 --> 04:06:41,439
TO THIS DISCUSSION.

6790
04:06:41,439 --> 04:06:43,641
OUR COMMITTEE WAS ENTHUSIASTIC

6791
04:06:43,641 --> 04:06:44,876
ABOUT THIS RFA, IT WAS

6792
04:06:44,876 --> 04:06:46,044
INFOIVATIVE AND HAD THE

6793
04:06:46,044 --> 04:06:48,579
POTENTIAL TO ADVANCE THE FIELD

6794
04:06:48,579 --> 04:06:50,314
OF IMPLEMENTATION SCIENCE.

6795
04:06:50,314 --> 04:06:52,150
I THINK IT'S TRUE TO SAY THAT A

6796
04:06:52,150 --> 04:06:53,117
LOT OF IMPLEMENTATION SCIENCE

6797
04:06:53,117 --> 04:06:55,153
RESEARCH FOCUSES ON THE

6798
04:06:55,153 --> 04:06:56,988
IMPLEMENTATION BUT NOT AS MUCH

6799
04:06:56,988 --> 04:06:58,990
ON SCALE UP AND SUSTAINABILITY,

6800
04:06:58,990 --> 04:07:00,358
AND SO I THOUGHT THAT WAS A

6801
04:07:00,358 --> 04:07:02,060
REALLY NICE WAY TO ADVANCE THE

6802
04:07:02,060 --> 04:07:02,527
FIELD.

6803
04:07:02,527 --> 04:07:04,796
SO FOCUS ON LUNG CANCER

6804
04:07:04,796 --> 04:07:09,901
SCREENING AS WELL AS TOBACCO USE

6805
04:07:09,901 --> 04:07:14,172
TREATMENT WAS ALSO THOUGHT THAT

6806
04:07:14,172 --> 04:07:15,873
HAVE HIGH IMPACTENTIOUS

6807
04:07:15,873 --> 04:07:18,576
SPECIALLY AS IT ALIGNED AROUND

6808
04:07:18,576 --> 04:07:20,178
CANCER MORTALITY AND I THINK IT

6809
04:07:20,178 --> 04:07:21,712
WAS ALSO THOUGHT THIS PARTICULAR

6810
04:07:21,712 --> 04:07:24,449
MECHANISM THAT UG3 AND UH3,

6811
04:07:24,449 --> 04:07:26,150
WOULD BE PARTICULARLY

6812
04:07:26,150 --> 04:07:28,986
APPROPRIATE FOR THIS TYPE OF

6813
04:07:28,986 --> 04:07:32,090
TOPIC BECAUSE IT GIVES NCI A

6814
04:07:32,090 --> 04:07:37,528
CHANCE TO REALLY KIND OF HAVE

6815
04:07:37,528 --> 04:07:38,129
INFLUENCE AS POTENTIALLY

6816
04:07:38,129 --> 04:07:41,199
DISCONTINUE THESE STUDIES THAT

6817
04:07:41,199 --> 04:07:42,834
MAY NOT BE MEETING MILESTONES IN

6818
04:07:42,834 --> 04:07:44,001
THE FIRST COUPLE OF YEARS.

6819
04:07:44,001 --> 04:07:48,272
I THINK THERE WAS DISCUSSION

6820
04:07:48,272 --> 04:07:49,974
ABOUT WELL THERE WOULD BE ENOUGH

6821
04:07:49,974 --> 04:07:51,409
IN COMMON BETWEEN THE 2

6822
04:07:51,409 --> 04:07:53,044
DIFFERENT RFAs AND TOPICS I

6823
04:07:53,044 --> 04:07:54,445
THINK YOU CAN SEE FROM THE THEN

6824
04:07:54,445 --> 04:07:56,981
DIAGRAM THIS IS ABOUT THE SCALE

6825
04:07:56,981 --> 04:07:59,083
UP APPROACH THAT REALLY IS THE

6826
04:07:59,083 --> 04:08:00,384
COMMONALITY AND I THINK

6827
04:08:00,384 --> 04:08:01,185
TAKEN--THEY WE WERE REASSURED

6828
04:08:01,185 --> 04:08:04,922
THAT THERE WOULD BE ENOUGH KIND

6829
04:08:04,922 --> 04:08:06,290
OF COMMON SCIENCE THEY CAN MOVE

6830
04:08:06,290 --> 04:08:07,592
FORWARD AND I PERSONALLY THINK

6831
04:08:07,592 --> 04:08:12,330
IT'S A GREAT IDEA TO KIND OF

6832
04:08:12,330 --> 04:08:13,297
LEVERAGE THE EXISTING

6833
04:08:13,297 --> 04:08:14,599
INFRASTRUCTURE LIKE THE NIH

6834
04:08:14,599 --> 04:08:16,667
COLLABORATORY THAT HAS A REALLY

6835
04:08:16,667 --> 04:08:18,269
WELL KNOWN COORDINATING CENTER

6836
04:08:18,269 --> 04:08:20,738
AND CONTINUES TO CRANK OUT A LOT

6837
04:08:20,738 --> 04:08:22,273
OF PUBLICATIONS EVEN THOUGH I'M

6838
04:08:22,273 --> 04:08:23,808
STILL INVOFFED IN PANELS AND

6839
04:08:23,808 --> 04:08:25,143
PUBLICATIONS EVEN THOUGH I WAS

6840
04:08:25,143 --> 04:08:27,478
FUNDED OVER 5 YEARS AGO.

6841
04:08:27,478 --> 04:08:28,846
SO I THINK THAT WILL BE A REALLY

6842
04:08:28,846 --> 04:08:30,348
GREAT WAY TO KEENED OF LEVERAGE

6843
04:08:30,348 --> 04:08:31,916
SOME OF THE EXISTING

6844
04:08:31,916 --> 04:08:36,020
INFRASTRUCTURE AND RESOURCES

6845
04:08:36,020 --> 04:08:36,320
THAT EXIST.

6846
04:08:36,320 --> 04:08:38,389
AND I WILL DEFER TO MY OTHER

6847
04:08:38,389 --> 04:08:39,657
COMMITTEE MEMBERS FOR COMMENT.

6848
04:08:39,657 --> 04:08:42,960
>> MARK AND THEN LISA?

6849
04:08:42,960 --> 04:08:46,664
>> SURE, I AGREE WITH ALL
OF

6850
04:08:46,664 --> 04:08:48,766
THOSE COMMENTS AND STRONGLY

6851
04:08:48,766 --> 04:08:49,567
SUPPORT THE PROPOSAL.

6852
04:08:49,567 --> 04:08:52,203
ONE MY CONCERNS WAS THE 60

6853
04:08:52,203 --> 04:08:53,704
CLINIC RULE WHICH IS CHALLENGING

6854
04:08:53,704 --> 04:08:56,507
WHEN YOU SAY RANDOMIZED EACH

6855
04:08:56,507 --> 04:08:58,576
ARM, QACs TO DO REAL

6856
04:08:58,576 --> 04:08:59,510
IMPLEMENTATION CHANGE THAT, KIND

6857
04:08:59,510 --> 04:09:01,279
OF MAKES ME BREAK OUT IN A SWEAT

6858
04:09:01,279 --> 04:09:04,015
A LITTLE BIT BUT I THINK AS LONG

6859
04:09:04,015 --> 04:09:06,117
AS IT'S SET UP IN A WAY THAT WE

6860
04:09:06,117 --> 04:09:07,451
CAN ADDRESS THE LAST MILE

6861
04:09:07,451 --> 04:09:10,321
INITIATIVE AND GO TO THE KAISER

6862
04:09:10,321 --> 04:09:11,689
PERMANENTE, I WOULD SAY WE CAN

6863
04:09:11,689 --> 04:09:13,891
DO THAT BUT WE'RE AT THE LESS

6864
04:09:13,891 --> 04:09:15,092
RESOURCE SITES IF IT CAN BE SET

6865
04:09:15,092 --> 04:09:16,861
UP IN A WAY TO GET THE

6866
04:09:16,861 --> 04:09:18,129
STATISTICAL POWER YOU NEED

6867
04:09:18,129 --> 04:09:27,672
ACROSS SITES, I THINK THAT'S

6868
04:09:27,672 --> 04:09:28,539
GREAT.

6869
04:09:28,539 --> 04:09:28,839
>> THANKS.

6870
04:09:28,839 --> 04:09:30,074
>> GREAT PRESENTATION AND
GREAT

6871
04:09:30,074 --> 04:09:32,543
SUMMARY OF OUR DISCUSSIONS, SO I

6872
04:09:32,543 --> 04:09:33,844
AM NOT INVOLVED IN THE LUNG

6873
04:09:33,844 --> 04:09:36,280
CANCER WORLD AT ALL BUT IN TERPS

6874
04:09:36,280 --> 04:09:37,782
OF DISPARITIES, I SAW NICE

6875
04:09:37,782 --> 04:09:40,484
OPPORTUNITY FIST ARE THIS WORK

6876
04:09:40,484 --> 04:09:42,153
TO ADDRESS CORRELATIVE SCIENCE

6877
04:09:42,153 --> 04:09:43,054
RELATED TO SCIENCE DISPARITIES

6878
04:09:43,054 --> 04:09:46,190
AND EVEN THOUGH YOU'RE LOOKING

6879
04:09:46,190 --> 04:09:48,125
AT KALING UP, IT WOULD BE

6880
04:09:48,125 --> 04:09:49,660
WONDERFUL TO SPECIFICALLY ENGAGE

6881
04:09:49,660 --> 04:09:50,695
RESEARCHERS TO COLLECT SPECIMENS

6882
04:09:50,695 --> 04:09:53,164
THAT CAN LOOK AT GERM LINE

6883
04:09:53,164 --> 04:09:54,765
GENETIC ANCESTRY BECAUSE THERE

6884
04:09:54,765 --> 04:09:57,034
HAVE BEEN SOME SIGNAL THAT

6885
04:09:57,034 --> 04:09:59,170
AFRICAN GERM LINE, GENETIC

6886
04:09:59,170 --> 04:10:00,137
AFRICAN ANCESTRY IS ASSOCIATED

6887
04:10:00,137 --> 04:10:01,672
WITH SOMETHING THAT INCREASES

6888
04:10:01,672 --> 04:10:03,341
SENSITIVITY TO TO BACK O RELATED

6889
04:10:03,341 --> 04:10:04,308
LUNG CANCERS, SO IT WOULD BE

6890
04:10:04,308 --> 04:10:07,378
NICE TO SEE THAT TYPE OF--THAT

6891
04:10:07,378 --> 04:10:10,681
RESEARCH SUPPORTED WITH THESE AS

6892
04:10:10,681 --> 04:10:15,419
WELL. 

6893
04:10:15,419 --> 04:10:17,455
SNRG OTHER DISCUSSION.

6894
04:10:17,455 --> 04:10:18,289
>> ONE, 2, 3.

6895
04:10:18,289 --> 04:10:20,558
>> THANKS CHRIS FROM
MICHIGAN, I

6896
04:10:20,558 --> 04:10:22,526
NEED TO DOUBLE DOWN ON MARK'S

6897
04:10:22,526 --> 04:10:24,262
COMMENT ABOUT THE 60 SITES AND

6898
04:10:24,262 --> 04:10:27,798
I'M READING YOUR REPORT HERE,

6899
04:10:27,798 --> 04:10:29,033
THE RATIONAL IS 60 SITES WOULD

6900
04:10:29,033 --> 04:10:30,468
BE TWICE THE MEDIAN NUMBER OF

6901
04:10:30,468 --> 04:10:32,436
SITES OF THE CURRENT PORTFOLIO

6902
04:10:32,436 --> 04:10:34,705
BUT YOU'RE NOT GIVING THEM

6903
04:10:34,705 --> 04:10:36,140
DOUBLE THE DIRECT COST BUDGET

6904
04:10:36,140 --> 04:10:40,378
PER PROGEC, SO, I THINK THAT'S A

6905
04:10:40,378 --> 04:10:40,911
HUGE ISSUE.

6906
04:10:40,911 --> 04:10:42,546
I WOULD ASK YOU TO RECONSIDER

6907
04:10:42,546 --> 04:10:45,082
THAT AND INSTEAD HAVE THE REVIEW

6908
04:10:45,082 --> 04:10:46,117
COMMITTEE CAREFULLY ASSESS THE

6909
04:10:46,117 --> 04:10:49,153
DIVERSITY OF THE SITES, THE

6910
04:10:49,153 --> 04:10:51,055
ADQUAISY OF THE REPRESENTATION,

6911
04:10:51,055 --> 04:10:52,089
THE ACTUAL CAPACITY TO RECRUIT

6912
04:10:52,089 --> 04:10:55,960
IN A PHYSICAL LOCATION, IT'S

6913
04:10:55,960 --> 04:10:57,028
DIFFERENT ACROSS--YOU MIGHT HAVE

6914
04:10:57,028 --> 04:10:58,763
45 SITES ON PAPER AND 25 THAT

6915
04:10:58,763 --> 04:11:01,699
ARE DOING THE REAL WORK, SO I

6916
04:11:01,699 --> 04:11:05,303
WOULD STRONGLY ENCOURAGE YOU TO

6917
04:11:05,303 --> 04:11:09,807
RECONSIDER THAT.

6918
04:11:09,807 --> 04:11:10,174
THANKS.

6919
04:11:10,174 --> 04:11:19,283
>> OTHERS, YES, 1, 2,
PLEASE?

6920
04:11:19,283 --> 04:11:20,651
>> NETWORK YEAH, I REALLY

6921
04:11:20,651 --> 04:11:24,755
APPLAUD THIS CASE WHERE YOU TAKE

6922
04:11:24,755 --> 04:11:25,589
INTERVENTIONS AND DETERMINING

6923
04:11:25,589 --> 04:11:28,826
IMPLEMENTATION BUT I WAS REALLY

6924
04:11:28,826 --> 04:11:30,861
STRUCK BY DR. PHIL CASTLES

6925
04:11:30,861 --> 04:11:32,229
PRESENTATION, THE OTHER NIGHT

6926
04:11:32,229 --> 04:11:34,532
AND HE TALKED ABOUT HOW, YOU

6927
04:11:34,532 --> 04:11:35,833
KNOW DOING SCREENING IS REALLY

6928
04:11:35,833 --> 04:11:38,436
GREAT BUT THEN HAVE YOU SOME

6929
04:11:38,436 --> 04:11:39,704
DOWN STREAM NEGATIVE

6930
04:11:39,704 --> 04:11:41,405
CONSEQUENCES, MEANING THAT IF

6931
04:11:41,405 --> 04:11:43,274
YOU ARE POSITIVE, YOU TEST

6932
04:11:43,274 --> 04:11:45,776
POSITIVE ON SOME SCREENINGS THEN

6933
04:11:45,776 --> 04:11:47,078
WHAT HAPPENS IN AND I'M

6934
04:11:47,078 --> 04:11:48,679
WONDERING IF THAT MITOCHONDRIAL

6935
04:11:48,679 --> 04:11:49,980
BE SOMETHING TO CONSIDER--MIGHT

6936
04:11:49,980 --> 04:11:52,350
BE SOMETHING TO CONSIDER WHAT

6937
04:11:52,350 --> 04:11:56,754
ARE THE UNINTENDED CONSEQUENCES

6938
04:11:56,754 --> 04:11:58,289
OF LAUNCHING A LUNG CANCER

6939
04:11:58,289 --> 04:12:00,324
SCREENING TAKING THAT INTO

6940
04:12:00,324 --> 04:12:03,627
CONSIDERATION, I PROVIDE

6941
04:12:03,627 --> 04:12:09,834
IMPORTANT INFORMATION. 

6942
04:12:09,834 --> 04:12:13,771
THE OTHER IS THAT WHEN YOU'RE

6943
04:12:13,771 --> 04:12:15,606
SMOKER IT'S HIGHLY OFFENSIVE ON

6944
04:12:15,606 --> 04:12:17,575
CIGARETTES AND/OR TO PACK O

6945
04:12:17,575 --> 04:12:21,579
PRODUCT AND I WAS WONDERING IF

6946
04:12:21,579 --> 04:12:23,247
THAT'S TAKEN INTO CONSIDERATION

6947
04:12:23,247 --> 04:12:25,416
WHEN YOU'RE LAUNCHING AN

6948
04:12:25,416 --> 04:12:27,651
INTERVENTION FOR SMOKING

6949
04:12:27,651 --> 04:12:32,723
CESSATION, IS THERE ANY KIND OF

6950
04:12:32,723 --> 04:12:36,727
INNOVATION THAT WOULD TREAT MORE

6951
04:12:36,727 --> 04:12:37,728
HIGHLY DEPENDENT INDIVIDUALS,

6952
04:12:37,728 --> 04:12:41,599
MAYBE SOMETHING THAT IS MORE

6953
04:12:41,599 --> 04:12:45,102
CULTURALLY TAILORED TO A CANCER

6954
04:12:45,102 --> 04:12:46,203
SURVIFFOR SO THAT WOULD BE MORE

6955
04:12:46,203 --> 04:12:48,506
INTERESTED IN TAKING UP A

6956
04:12:48,506 --> 04:12:50,808
SMOKING CESSATION PROGRAM,

6957
04:12:50,808 --> 04:12:53,144
BECAUSE SOMETIMES THAT'S A

6958
04:12:53,144 --> 04:12:54,445
CHALLENGE AS WELL, IS THE

6959
04:12:54,445 --> 04:12:57,681
INTEREST IN ACTUALLY ENGAGING IN

6960
04:12:57,681 --> 04:12:59,250
SMOKING CESSATION, SO, THAT

6961
04:12:59,250 --> 04:13:01,919
MIGHT BE SOMETHING TO CONSIDER

6962
04:13:01,919 --> 04:13:02,486
AS WELL.

6963
04:13:02,486 --> 04:13:04,355
>> YEAH, SO THANKS IF ARE
THOSE

6964
04:13:04,355 --> 04:13:05,856
COUPLE COMMENTS, JUST TO

6965
04:13:05,856 --> 04:13:07,024
CLARIFYOT KREENING PROCESS AND

6966
04:13:07,024 --> 04:13:07,892
APPRECIATE THE COMEBTS EARLIER

6967
04:13:07,892 --> 04:13:09,627
TODAY AS WELL OF THE IDEA OF

6968
04:13:09,627 --> 04:13:14,331
JUST SCREENING AND THEN NOTHING,

6969
04:13:14,331 --> 04:13:16,333
NOT BEING THE APPROPRIATE CARE.

6970
04:13:16,333 --> 04:13:18,335
SO EVIDENT BASED AT LEAST AS

6971
04:13:18,335 --> 04:13:21,205
DEFINED, DOES ENCLOUD THAT

6972
04:13:21,205 --> 04:13:23,140
PATHWAY, JUST BEYOND THE INITIAL

6973
04:13:23,140 --> 04:13:26,377
SCREEN BECAUSE NOBODY SHOULD GET

6974
04:13:26,377 --> 04:13:27,578
STUCK WITH NO CLEAR WAY TO GO

6975
04:13:27,578 --> 04:13:30,314
AND SO IT BECOMES A CHALLENGE OF

6976
04:13:30,314 --> 04:13:32,683
HOW DO WE MAKE HUR WE SCALE UP

6977
04:13:32,683 --> 04:13:33,984
ALL ASPECTS OF THE KREENING

6978
04:13:33,984 --> 04:13:36,821
PROCESS, I THINK THE NOTE ABOUT

6979
04:13:36,821 --> 04:13:37,321
EVIDENCE BASED CESSATION

6980
04:13:37,321 --> 04:13:38,489
SERVICES, AGAIN WITH THIS

6981
04:13:38,489 --> 04:13:40,691
INITIATIVE WE'RE TRYING TO

6982
04:13:40,691 --> 04:13:41,292
CAPITALIZE ON EXISTS

6983
04:13:41,292 --> 04:13:42,226
INTERVENTIONS BUT I THINK IT

6984
04:13:42,226 --> 04:13:44,628
DOES GO TO THE INVESTIGATIVE

6985
04:13:44,628 --> 04:13:45,763
TEAMS TO NOT JUST THINK ABOUT

6986
04:13:45,763 --> 04:13:47,097
THE SUPPLY OF THE INTERVENTIONS

6987
04:13:47,097 --> 04:13:48,766
BUT THE DEMAND FOR THEM, AND THE

6988
04:13:48,766 --> 04:13:51,502
DIFFERENT APPROACHES TO TRY AND

6989
04:13:51,502 --> 04:13:52,736
MAKE SURE THAT THE POPULATION

6990
04:13:52,736 --> 04:13:54,104
THAT COULD BENEFIT FROM THEM IS

6991
04:13:54,104 --> 04:13:56,674
ENGAGED IN CARE AND SO MANY OF

6992
04:13:56,674 --> 04:13:57,508
OUR IMPLEMENTATION STUDIES RISE

6993
04:13:57,508 --> 04:14:00,611
OR FALL ON THE ABILITY TO ENGAGE

6994
04:14:00,611 --> 04:14:02,246
FOLKS WHO WOULD POTENTIALLY

6995
04:14:02,246 --> 04:14:03,180
BENEFIT FROM THOSE INTERVENTIONS

6996
04:14:03,180 --> 04:14:04,381
BUT IT'S A GREAT POINT TO MAKE

6997
04:14:04,381 --> 04:14:07,585
SURE THAT WE'RE NOT CREATING A

6998
04:14:07,585 --> 04:14:08,385
MISMATCH BETWEEN THE

6999
04:14:08,385 --> 04:14:10,454
INTERVENTIONS THAT ARE OFFERED

7000
04:14:10,454 --> 04:14:12,089
AND THE NEED OR THE PREFERENCE

7001
04:14:12,089 --> 04:14:13,123
FOR THEM.

7002
04:14:13,123 --> 04:14:23,567
N1 LAST COMMENT FROM RAY?

7003
04:14:33,377 --> 04:14:34,678
NDAVE IRD CONGRATULATIONS, VERY

7004
04:14:34,678 --> 04:14:38,582
NICE PRESENTITION, AS I SAID

7005
04:14:38,582 --> 04:14:39,750
EARLIER, IF WE ARE ANYTHING TO

7006
04:14:39,750 --> 04:14:41,185
CHANGE CANCER AS WE KNOW IT,

7007
04:14:41,185 --> 04:14:43,320
LUNG CANCER HAS TO BE A HUGE

7008
04:14:43,320 --> 04:14:45,789
COMPONENT OF THAT AND EARLY

7009
04:14:45,789 --> 04:14:51,529
DETECTION IS PROBABLY A CROWN

7010
04:14:51,529 --> 04:14:51,962
JEWEL.

7011
04:14:51,962 --> 04:14:52,963
I WILL JUST LET EVERYBODY KNOW

7012
04:14:52,963 --> 04:14:55,266
THAT THE NATIONAL LUNG CANCER

7013
04:14:55,266 --> 04:14:57,134
ROUND TABLE HAS RECOGNIZED LUNG

7014
04:14:57,134 --> 04:14:58,435
CANCER SCREENING, THE GAP IN

7015
04:14:58,435 --> 04:15:01,539
LUNG CANCER SCREENING AS AN

7016
04:15:01,539 --> 04:15:02,172
IMPLEMENTATION SCIENCE PROBLEM.

7017
04:15:02,172 --> 04:15:03,841
SO LAST YEAR AT THE ANNUAL

7018
04:15:03,841 --> 04:15:05,442
MEETING OF THE NATIONAL LUNG

7019
04:15:05,442 --> 04:15:07,344
CANCER ROUND TABLE WE ACTUALLY

7020
04:15:07,344 --> 04:15:10,381
INVITED DAVID TO COME IN AND DO

7021
04:15:10,381 --> 04:15:12,816
AN IS PROGRAM IN THIS, JUST

7022
04:15:12,816 --> 04:15:15,419
SPEAKS TO THE ENORMITY I THINK

7023
04:15:15,419 --> 04:15:16,921
OF THE OPPORTUNITY THAT A

7024
04:15:16,921 --> 04:15:18,222
NARRATIVE LIKE THIS WOULD

7025
04:15:18,222 --> 04:15:18,989
REPRESENT.

7026
04:15:18,989 --> 04:15:26,330
SO CONGRATTULESS FOR BRINGING IN

7027
04:15:26,330 --> 04:15:26,564
FORWARD.

7028
04:15:26,564 --> 04:15:30,568
THIS, WE NEED TO MOVE PRETTY

7029
04:15:30,568 --> 04:15:30,901
QUICKLY.

7030
04:15:30,901 --> 04:15:34,405
>> I JUST HAVE A QUICK
QUESTION,

7031
04:15:34,405 --> 04:15:36,707
SO WE LOOK NATIONAL ON SCREEN

7032
04:15:36,707 --> 04:15:38,876
FOR YEARS AS THE WORK TURNS

7033
04:15:38,876 --> 04:15:40,077
ASIDE A DOZEN THINGS ABOUT IT

7034
04:15:40,077 --> 04:15:42,079
WHETHER OR NOT TO ACTUALLY DO IT

7035
04:15:42,079 --> 04:15:44,415
AT ALL OR NOT, EVENTUALLY WE DID

7036
04:15:44,415 --> 04:15:45,716
BUT THEN WHEN YOU LOOK AT THIS,

7037
04:15:45,716 --> 04:15:49,486
DID YOU CONSIDER THINGS LIKE

7038
04:15:49,486 --> 04:15:50,287
FALSE-POSITIVES THAT THE IMPACT

7039
04:15:50,287 --> 04:15:52,723
THAT NOT READING THE TECHNOLOGY

7040
04:15:52,723 --> 04:15:53,691
APPROPRIATELY COULD BE--HAVE AN

7041
04:15:53,691 --> 04:15:54,625
IMPACT AND THEN DID YOU ALSO

7042
04:15:54,625 --> 04:15:58,329
LOOK AT THE ECONOMIC IMPACT OF

7043
04:15:58,329 --> 04:15:59,363
SCALING, A SCREENING TOOL LIKE

7044
04:15:59,363 --> 04:15:59,563
THIS.

7045
04:15:59,563 --> 04:16:01,632
FIRST OF ALL I LOVE THE MODEL, I

7046
04:16:01,632 --> 04:16:03,033
THINK YOU PICKED 1 THAT'S GOING

7047
04:16:03,033 --> 04:16:08,772
TO HAVE TO REQUIRE SOME REAL

7048
04:16:08,772 --> 04:16:11,642
STUDY UPFRONT TO INSURE THAT THE

7049
04:16:11,642 --> 04:16:13,077
ECONOMIC IMPACT ISN'T SO GREAT

7050
04:16:13,077 --> 04:16:14,578
THAT WE LITERALLY MIGHT NOT BE

7051
04:16:14,578 --> 04:16:18,949
ABLE TO ABSORB IT.

7052
04:16:18,949 --> 04:16:19,950
NCOMMITTEE CHAIR 1 LAST COMMENT.

7053
04:16:19,950 --> 04:16:20,985
>> ALL RIGHT, I JUST WANT
TO

7054
04:16:20,985 --> 04:16:22,586
COMMENT ABOUT THE NUMBER OF

7055
04:16:22,586 --> 04:16:24,888
CLINIC SITES THAT WOULD BE

7056
04:16:24,888 --> 04:16:26,523
REQUIRED BECAUSE I THINK THAT

7057
04:16:26,523 --> 04:16:27,625
COMMENT HAS COME UP A COUPLE

7058
04:16:27,625 --> 04:16:29,493
TIMES AND I WANT TO SAY, YOU

7059
04:16:29,493 --> 04:16:31,328
KNOW IN THE WORK THAT I'VE DONE,

7060
04:16:31,328 --> 04:16:34,031
YOU KNOW OFTEN TIMES CLINICS ARE

7061
04:16:34,031 --> 04:16:35,399
ORGANIZED IN CLUSTERS SO YOU

7062
04:16:35,399 --> 04:16:37,635
KNOW IN A STUDY I DID, WE WORKED

7063
04:16:37,635 --> 04:16:39,603
WITH 8 HEALTH CENTERS THAT

7064
04:16:39,603 --> 04:16:40,904
OPERATED 26 CLINICS AND WE'RE

7065
04:16:40,904 --> 04:16:42,973
DOING A SCALE UP AS A THIRD AIM

7066
04:16:42,973 --> 04:16:45,609
TO OUR MOON SHOT STUDY, THAT'S

7067
04:16:45,609 --> 04:16:48,412
INTENDING TO WORK WITH 130

7068
04:16:48,412 --> 04:16:52,282
CLINICS AND WE ARE ACTUALLY

7069
04:16:52,282 --> 04:16:53,784
EDUCATING ABOUT 40 DIFFERENT

7070
04:16:53,784 --> 04:16:56,387
REPRESENTATIVES BECAUSE EACH 1

7071
04:16:56,387 --> 04:16:57,254
OF THOSE CENTRALIZED STAFF WORKS

7072
04:16:57,254 --> 04:16:59,556
WITH A VARIETY OF CLINICS AND

7073
04:16:59,556 --> 04:17:01,759
SO, I ACTUALLY AM NOT AT ALL,

7074
04:17:01,759 --> 04:17:03,661
LIKE FROM WHERE I SIT I'M NOT AT

7075
04:17:03,661 --> 04:17:05,696
ALL CONCERNED ABOUT THE 60

7076
04:17:05,696 --> 04:17:07,231
MINIMUM AND I THINK IT'S A

7077
04:17:07,231 --> 04:17:08,732
REALLY NICE WAY TO PUSH THE

7078
04:17:08,732 --> 04:17:10,567
FIELD FORWARD AND IN TERPS OF

7079
04:17:10,567 --> 04:17:12,870
DOLLAR FOR DOLLAR, LIKE YOU

7080
04:17:12,870 --> 04:17:15,139
DON'T SAY 30 IS X-MILLION AND SO

7081
04:17:15,139 --> 04:17:17,341
60 SHOULD BE TWICE THAT, BECAUSE

7082
04:17:17,341 --> 04:17:19,743
SCALE UP IS ABOUTENTIOUS

7083
04:17:19,743 --> 04:17:20,978
FICIENCYS AND SPREADING THINGS

7084
04:17:20,978 --> 04:17:22,379
TO THE WORLD ASK IT SHOULDN'T

7085
04:17:22,379 --> 04:17:26,283
COST AS MUCH AS THAT INITIAL IMP

7086
04:17:26,283 --> 04:17:26,583
REMENTATION.

7087
04:17:26,583 --> 04:17:27,818
THE OTHER POINT I WILL TAKE IN

7088
04:17:27,818 --> 04:17:29,553
TERMS OF POWER CALCULATIONS IS

7089
04:17:29,553 --> 04:17:31,388
THAT IF YOU CAN'T SCALE UP AND

7090
04:17:31,388 --> 04:17:32,923
YOU CAN'T SUSTAIN AND SO REALLY

7091
04:17:32,923 --> 04:17:34,692
WE NEED TO POWER THE STUDIES ON

7092
04:17:34,692 --> 04:17:36,160
THIS SUSTAINABILITY, WITH THE

7093
04:17:36,160 --> 04:17:37,995
IDEA THAT NOT EVERY SITE IF IT'S

7094
04:17:37,995 --> 04:17:39,763
GOING TO KALE UP IS GOING TO

7095
04:17:39,763 --> 04:17:45,102
SUSTAIN THAT IN THE SECOND YEAR.

7096
04:17:45,102 --> 04:17:45,769
>> ROOK, INTERESTING
DISCUSSION,

7097
04:17:45,769 --> 04:17:49,106
CAN WE HAVE A MOTION?

7098
04:17:49,106 --> 04:17:51,175
NI MOVE TO,A PROVE.

7099
04:17:51,175 --> 04:17:51,775
>> SECOND.

7100
04:17:51,775 --> 04:17:59,650
>> OKAY, ANY FURTHER
DISCUSSION.

7101
04:17:59,650 --> 04:18:01,952
NQUICKLY.

7102
04:18:01,952 --> 04:18:07,357
NREALLY QUICK, SO 1 COUPLE OF

7103
04:18:07,357 --> 04:18:08,459
POINTS TOBACCO DOCUMENTATION,

7104
04:18:08,459 --> 04:18:09,960
AND ADDITION IN PRIMARY CARE, I

7105
04:18:09,960 --> 04:18:13,397
SUSPECT THIS WILL NEED TO OCCUR

7106
04:18:13,397 --> 04:18:14,565
IS REALLY POOR, SO I THINK

7107
04:18:14,565 --> 04:18:16,633
ATTENTION TO HOW THAT IS GOING

7108
04:18:16,633 --> 04:18:18,368
TO BE ATTENDED TO ANDIME JUST AS

7109
04:18:18,368 --> 04:18:20,104
GUILTY WILL BE IMPORTANT.

7110
04:18:20,104 --> 04:18:23,507
SECOND THING IS STIGMA OF

7111
04:18:23,507 --> 04:18:25,375
TOBACCO USE NEEDS TO BE TAKEN

7112
04:18:25,375 --> 04:18:29,546
INTO ACCOUNT.

7113
04:18:29,546 --> 04:18:32,082
THAT'S ALL.

7114
04:18:32,082 --> 04:18:32,883
>> ERIN, SOUND BITE.

7115
04:18:32,883 --> 04:18:34,284
>> QUICK QUESTION, HOW
THIS WILL

7116
04:18:34,284 --> 04:18:37,221
INTERACT WITH THE IMPLEMENTATION

7117
04:18:37,221 --> 04:18:37,921
SCIENCE CENTERS THAT ALREADY

7118
04:18:37,921 --> 04:18:44,328
FUNDED AND HOW YOU PLAN TO

7119
04:18:44,328 --> 04:18:45,028
LEVERAGE THAT?

7120
04:18:45,028 --> 04:18:46,563
>> CENTERS THAT ARE FUNDED
IN

7121
04:18:46,563 --> 04:18:48,265
THEIR WANING YEARS HAVE PRACTICE

7122
04:18:48,265 --> 04:18:49,500
LABORATORIES SO THEY ALREADY

7123
04:18:49,500 --> 04:18:50,200
HAVE NETWORKS OF PARTICULAR

7124
04:18:50,200 --> 04:18:52,236
SITES AND THE IDEA IS TO CHIE

7125
04:18:52,236 --> 04:18:53,904
TRY TO LEVERAGE THOSE TYPES OF

7126
04:18:53,904 --> 04:18:58,075
NETWORKS AND OTHER NETWORKS.

7127
04:18:58,075 --> 04:18:59,643
AS FAR AS THE CENTERS IN THE

7128
04:18:59,643 --> 04:19:00,911
FIFTH YEAR, 1 CENTER IN THE

7129
04:19:00,911 --> 04:19:03,847
FOURTH YEAR, SO THERE'S 1 MIGHT

7130
04:19:03,847 --> 04:19:05,716
THINK THAT FOR THOSE THAT WOULD

7131
04:19:05,716 --> 04:19:07,351
PROPOSE A TRIAL WHO ARE PART OF

7132
04:19:07,351 --> 04:19:08,519
THAT CONSORTIUM IT WOULD BE A

7133
04:19:08,519 --> 04:19:10,921
NAIS OPPORTUNITY TO CONTINUE,

7134
04:19:10,921 --> 04:19:12,356
BUT IT'S NOT AN ABILITY TO MATCH

7135
04:19:12,356 --> 04:19:16,426
IT DIRECTLY TO THAT.

7136
04:19:16,426 --> 04:19:16,794
>> THANK YOU.

7137
04:19:16,794 --> 04:19:22,065
WE NEED TO VOTE.

7138
04:19:22,065 --> 04:19:22,332
>> OKAY.

7139
04:19:22,332 --> 04:19:23,467
>> ARE THERE ANY NAYS.

7140
04:19:23,467 --> 04:19:24,635
>> WE HAVE A MOTION.

7141
04:19:24,635 --> 04:19:29,606
>> I WILL BE 1 NAY.

7142
04:19:29,606 --> 04:19:36,947
>> ONE NAY, ANY
ABSTENTIONS?

7143
04:19:36,947 --> 04:19:38,482
OKAY, THERE'S NOT UNANIMOUS,

7144
04:19:38,482 --> 04:19:40,784
THERE'S 1 NAY.

7145
04:19:40,784 --> 04:19:40,984
NGOOD.

7146
04:19:40,984 --> 04:19:41,952
THANK YOU.

7147
04:19:41,952 --> 04:19:42,986
>> THAT WAS TERRIFIC
DISCUSSION.

7148
04:19:42,986 --> 04:19:48,192
AND A VERY IMPORTANT 1 AND I

7149
04:19:48,192 --> 04:19:49,493
WOULD EDITORIALLY SAY IF WE'RE

7150
04:19:49,493 --> 04:19:51,895
GOING TO SUSTAIN, WE HAVE TO DO

7151
04:19:51,895 --> 04:19:53,197
IT WITH AN EFFICIENT WAY O I

7152
04:19:53,197 --> 04:19:55,265
THINK THIS IS VERY INTERESTING.

7153
04:19:55,265 --> 04:19:57,668
OKAY, THE NEXT IS SOCIAL

7154
04:19:57,668 --> 04:19:59,636
DETERMINANTS OF HEALTH AND

7155
04:19:59,636 --> 04:20:01,171
QUALITY OF CARE CONTRIBUTORS TO

7156
04:20:01,171 --> 04:20:03,907
CANCER DISPARITIES IN PEOPLE

7157
04:20:03,907 --> 04:20:04,174
WITH HIV.

7158
04:20:04,174 --> 04:20:08,045
WE'RE GOING TO HAVE A

7159
04:20:08,045 --> 04:20:09,213
PRESENTATION FROM REBECCA HUPPI

7160
04:20:09,213 --> 04:20:12,249
AND OUR GROUP AND ANN MARIE,

7161
04:20:12,249 --> 04:20:15,919
KAREN AND ERIC.

7162
04:20:15,919 --> 04:20:16,186
REBECCA?

7163
04:20:16,186 --> 04:20:16,587
>> THAIRNG YOU.

7164
04:20:16,587 --> 04:20:20,824
FIRST WE WILL LIKE TO THANK

7165
04:20:20,824 --> 04:20:21,859
DR. [INDISCERNIBLE], LOPEZ AND

7166
04:20:21,859 --> 04:20:22,926
ROBERSTON FOR THEIR HELPFUL

7167
04:20:22,926 --> 04:20:24,761
INPUT REKNARREDDING THE CONCEPT.

7168
04:20:24,761 --> 04:20:29,533
THE OFFICE OF HIV AND AIDS

7169
04:20:29,533 --> 04:20:32,769
MALIGNANCY WITH THE CENTER TO

7170
04:20:32,769 --> 04:20:33,837
REDUCE CANCER DISPARITIES IN

7171
04:20:33,837 --> 04:20:34,805
COLLABORATION WITH THE CANCER

7172
04:20:34,805 --> 04:20:37,541
CONTROL AND POPPULES STUDIES,

7173
04:20:37,541 --> 04:20:38,275
DIVISION OF CANCER PREVENTION

7174
04:20:38,275 --> 04:20:40,777
AND THE DIVISION OF CANCER

7175
04:20:40,777 --> 04:20:42,212
TREATMENT AND DIAGNOSIS IS

7176
04:20:42,212 --> 04:20:45,182
PRESENTING THIS PROPOSAL FOR A

7177
04:20:45,182 --> 04:20:46,383
NEW RFA ENTITLED SOCIAL

7178
04:20:46,383 --> 04:20:47,651
DETERMINE NABTS OF HEALTH AND

7179
04:20:47,651 --> 04:20:52,089
QUALITY OF CARE CONTRIBUTORS TO

7180
04:20:52,089 --> 04:20:55,459
CANCER DISPARITIES IN PEOPLE

7181
04:20:55,459 --> 04:20:56,860
WITH HIV.

7182
04:20:56,860 --> 04:20:58,495
SO ROBIN TEED THIS UP QUITE WELL

7183
04:20:58,495 --> 04:20:59,897
FOR ME, THERE ARE 1.2 MILL

7184
04:20:59,897 --> 04:21:02,966
WHEREON PEOPLE IN THEs, WITH

7185
04:21:02,966 --> 04:21:08,805
HIV, WITH 32,000 NEW INFECTIONS

7186
04:21:08,805 --> 04:21:11,375
THAT OCCURRED IN 2021, THOSE NEW

7187
04:21:11,375 --> 04:21:12,976
INFECTIONS WERE HIGHLY

7188
04:21:12,976 --> 04:21:15,846
CONCENTRATED IN 48 COUNTIES, DC

7189
04:21:15,846 --> 04:21:17,948
AND SAN JUAN PUERTO RICO, WITH

7190
04:21:17,948 --> 04:21:19,583
GREATER THAN 52% OF NEW

7191
04:21:19,583 --> 04:21:21,385
INFECTIONS OCCURRING IN THE

7192
04:21:21,385 --> 04:21:22,486
SOUTH EMPLOY THIS IS

7193
04:21:22,486 --> 04:21:23,620
DEMONSTRATED IN THE HEAT MAP ON

7194
04:21:23,620 --> 04:21:27,124
THE RIGHT HAND SIDE OF THE

7195
04:21:27,124 --> 04:21:27,591
SLIDE.

7196
04:21:27,591 --> 04:21:29,293
CANCER'S BEEN A PROMINENT

7197
04:21:29,293 --> 04:21:31,495
MANIFESTATION OF THE HIV/AIDS

7198
04:21:31,495 --> 04:21:32,663
EPIDEMIC SINCE THE BEGINNING AND

7199
04:21:32,663 --> 04:21:36,833
IS 1 OF THE MOST IF NOT THE MOST

7200
04:21:36,833 --> 04:21:39,002
PREQUEPT CAUSE OF DEATH IN

7201
04:21:39,002 --> 04:21:42,940
PEOPLE WITH HIV IN THE UNITED

7202
04:21:42,940 --> 04:21:43,173
STATES.

7203
04:21:43,173 --> 04:21:45,208
PEOPLE WITH HIV WHEN COMPARED TO

7204
04:21:45,208 --> 04:21:48,011
THOSE WITHOUT HIV HAVE LOWER

7205
04:21:48,011 --> 04:21:49,646
CANCER SCREENING RATES, ARE LESS

7206
04:21:49,646 --> 04:21:53,116
LIKELY TO RECEIVE CANCER

7207
04:21:53,116 --> 04:21:54,484
TREATMENT HAVE MORE ADVANCED

7208
04:21:54,484 --> 04:21:56,553
CANCER DIAGNOSIS AND HIGHER

7209
04:21:56,553 --> 04:21:57,154
CANCER MORTALITY.

7210
04:21:57,154 --> 04:21:58,722
THERE ARE A NUMBER OF

7211
04:21:58,722 --> 04:22:02,259
CONTRIBUTING FACTORS TO THESE

7212
04:22:02,259 --> 04:22:04,795
DISPARITIES, THEY CAN BE PATIENT

7213
04:22:04,795 --> 04:22:05,762
DRIVEN, PROVIDER DRIVEN AND

7214
04:22:05,762 --> 04:22:07,698
HEALTH SYSTEMS RELATED ISSUES.

7215
04:22:07,698 --> 04:22:09,666
TO DATE MUCH OF THE WERE AND

7216
04:22:09,666 --> 04:22:11,234
SOCIAL DETERMINE NABTS OF HEALTH

7217
04:22:11,234 --> 04:22:15,305
AND HIV CARE OUTCOMES SHOWS

7218
04:22:15,305 --> 04:22:17,941
ASSOCIATIONS WEAN A SINGLE

7219
04:22:17,941 --> 04:22:20,944
FACTOR FOR EXAMPLE, POVERTY AND

7220
04:22:20,944 --> 04:22:22,646
CLINICAL OUTCOMES, HOWEVER,

7221
04:22:22,646 --> 04:22:25,983
SOCIAL DETERMINANTS OF HEALTH

7222
04:22:25,983 --> 04:22:28,285
ARE COMPLEX, INTERSECTING AND

7223
04:22:28,285 --> 04:22:28,585
REINFORCING.

7224
04:22:28,585 --> 04:22:31,655
SO THERE'S A NEED TO DEVELOP

7225
04:22:31,655 --> 04:22:33,724
MULTILEVEL APPROACHES TO BETTER

7226
04:22:33,724 --> 04:22:34,992
IMPROVE CANCER PREVENTION AND

7227
04:22:34,992 --> 04:22:39,396
COORDINATED CARE IN PEOPLE WITH

7228
04:22:39,396 --> 04:22:39,629
HIV.

7229
04:22:39,629 --> 04:22:42,332
SO THE PURPOSE OF THE RFA IS TO

7230
04:22:42,332 --> 04:22:45,135
EPICREASE THE NCI'S RESEARCH

7231
04:22:45,135 --> 04:22:45,769
PORTFOLIO, INVESTIGATING CANCER

7232
04:22:45,769 --> 04:22:48,338
DISPARITIES IN PEOPLE WITH HIV.

7233
04:22:48,338 --> 04:22:54,077
ALSO TO ADVANCE THE

7234
04:22:54,077 --> 04:22:56,013
UNDERSTANDING OF WHICH SOCIAL

7235
04:22:56,013 --> 04:22:56,713
DETERMINANTS OF HEALTH ARE

7236
04:22:56,713 --> 04:22:58,949
IMPORTANT AND HOW THEY INTERSECT

7237
04:22:58,949 --> 04:23:00,384
WITH CANCER CARE INIQUITIES TO

7238
04:23:00,384 --> 04:23:02,119
CONTRIBUTE TO DISPARITIES IN THE

7239
04:23:02,119 --> 04:23:03,854
PREVENTION, DIAGNOSIS AND

7240
04:23:03,854 --> 04:23:08,892
TREATMENT OUTCOMES OF PWITH HIV

7241
04:23:08,892 --> 04:23:10,060
AND CANCER WITH AN EXPECTATION

7242
04:23:10,060 --> 04:23:14,931
THAT THE RESEARCH MAY INFORM

7243
04:23:14,931 --> 04:23:15,999
FUTURE INTERVENTIONS.

7244
04:23:15,999 --> 04:23:17,601
NOW POTENTIAL AREAS OF RESEARCH

7245
04:23:17,601 --> 04:23:20,103
SCOPE INCLUDE RESEARCH TO BETTER

7246
04:23:20,103 --> 04:23:22,739
UNDERSTAND HOW MULTIPLE SOCIAL

7247
04:23:22,739 --> 04:23:23,673
DETERMINANTS OF HEALTH INTERACT

7248
04:23:23,673 --> 04:23:25,742
AND CONTRIBUTE TO HEALTH

7249
04:23:25,742 --> 04:23:27,144
DISPARITIES IN CANCER

7250
04:23:27,144 --> 04:23:29,312
PREVENTION, DIAGNOSIS, TREATMENT

7251
04:23:29,312 --> 04:23:32,649
AND OUTCOMES IN PEOPLE WITH HIV.

7252
04:23:32,649 --> 04:23:33,850
ALSO RESEARCH ILLICITTING HOW

7253
04:23:33,850 --> 04:23:35,819
PROVIEDMANNER LEVEL AND SYSTEM

7254
04:23:35,819 --> 04:23:37,220
LEVEL FACTORS INFLUENCE THE

7255
04:23:37,220 --> 04:23:40,057
QUALITY OF CANCER CARE TO PEOPLE

7256
04:23:40,057 --> 04:23:41,858
WITH HIV.

7257
04:23:41,858 --> 04:23:44,194
ALSO, RESEARCH IDENTIFYING AND

7258
04:23:44,194 --> 04:23:46,396
TESTING STRATEGIES, TO ALLEVIATE

7259
04:23:46,396 --> 04:23:47,431
SOCIAL DETERMINANTS OF HEALTH

7260
04:23:47,431 --> 04:23:50,300
THAT AFFECT PEOPLE WITH HIV

7261
04:23:50,300 --> 04:23:52,002
RECEIVING QUALITY CARE INCLUDING

7262
04:23:52,002 --> 04:23:57,374
ENROLL NOTHING CLINICAL TRIALS,

7263
04:23:57,374 --> 04:23:58,575
OR CANCER SCREENINGS.

7264
04:23:58,575 --> 04:24:01,678
THIS IS CERTAINLY NOT AN

7265
04:24:01,678 --> 04:24:03,180
EXHAUSTIVE LIST WE FEEL IT MAY

7266
04:24:03,180 --> 04:24:05,048
BE IMPORTANT TO ADD IN

7267
04:24:05,048 --> 04:24:05,649
ADDITIONAL AREAS OF RESEARCH

7268
04:24:05,649 --> 04:24:08,885
SCOPE TO THE RFA SO WE WILL

7269
04:24:08,885 --> 04:24:12,522
CONFER WITH OUR DCCPS AND OUR

7270
04:24:12,522 --> 04:24:13,390
DCCP COLLEAGUES TO DEVELOP

7271
04:24:13,390 --> 04:24:15,092
BULLETS THAT MAY BETTER REFLECT

7272
04:24:15,092 --> 04:24:16,893
THE ENTIRE SCOPE OF THE RFA,

7273
04:24:16,893 --> 04:24:19,963
HOWEVER, WE ALSO WANT TO WORK TO

7274
04:24:19,963 --> 04:24:27,604
AVOID BEING 2 PRESCRIPTIVE IN

7275
04:24:27,604 --> 04:24:29,539
THE RFA.

7276
04:24:29,539 --> 04:24:31,408
NOW HEALTH DISPARITIES ARE OFTEN

7277
04:24:31,408 --> 04:24:34,711
AMPLIFIED OF MEMBERS WHO ARE

7278
04:24:34,711 --> 04:24:35,412
OFTEN MULTIPLE, INTERSECTIONS

7279
04:24:35,412 --> 04:24:37,180
ISSUES UNDERSERVED AND

7280
04:24:37,180 --> 04:24:39,282
MARGINALIZED GROUPS INCLUDING

7281
04:24:39,282 --> 04:24:40,684
LOW SOCIOECONOMICCAL GROUPS

7282
04:24:40,684 --> 04:24:41,685
ISSUES UNDERREPRESENTED RACIAL

7283
04:24:41,685 --> 04:24:44,054
AND EKING NICK POPULATIONS,

7284
04:24:44,054 --> 04:24:44,688
SEXUAL AND IMENDER MINORITIES

7285
04:24:44,688 --> 04:24:47,691
AND THOSE WHO LIVE IN

7286
04:24:47,691 --> 04:24:49,059
GEOGRAPHICALLY ISOLATED AREAS.

7287
04:24:49,059 --> 04:24:52,262
FOR EXAMPLE, REGARDING NEW HIV

7288
04:24:52,262 --> 04:24:53,763
INFECTIONS IN THE UNITED STATES,

7289
04:24:53,763 --> 04:24:56,433
40% OF THE THE INFECTIONS OCCUR

7290
04:24:56,433 --> 04:24:58,135
IN BLACK AND AFRICAN AMERICAN

7291
04:24:58,135 --> 04:25:00,403
INDIVIDUALS, ALTHOUGH THIS

7292
04:25:00,403 --> 04:25:01,671
POPULATION MAKES UP ONLY 12% OF

7293
04:25:01,671 --> 04:25:04,975
THE U.S. POPULATION.

7294
04:25:04,975 --> 04:25:07,244
TWENTY-NINE% OF NEW INFECTIONS

7295
04:25:07,244 --> 04:25:09,346
OCCUR IN HISPANIC AND LATINO

7296
04:25:09,346 --> 04:25:10,981
INDIVIDUALS, EACH THOUGH THIS

7297
04:25:10,981 --> 04:25:12,015
POPULATION MAKES UP ONLY 18% OF

7298
04:25:12,015 --> 04:25:16,319
THE U.S. POPULATION.

7299
04:25:16,319 --> 04:25:18,555
NOW WHEN CONSIDERING THOSE

7300
04:25:18,555 --> 04:25:19,389
BELONGING TO MULTIPLE MINORITY

7301
04:25:19,389 --> 04:25:25,529
GROUPS ISSUES THE NEW INFECTIONS

7302
04:25:25,529 --> 04:25:30,967
WERE 25% IN BLACK MEN WHO HAVE

7303
04:25:30,967 --> 04:25:32,335
SEX WITH MEN.

7304
04:25:32,335 --> 04:25:35,572
AND HISPANIC OR LATINO MEN WHO

7305
04:25:35,572 --> 04:25:39,176
HAVE SEX IN MEN, OF INFECTIONS

7306
04:25:39,176 --> 04:25:41,811
IN WOMEN 54% OCCUR IN BLACK

7307
04:25:41,811 --> 04:25:44,381
AFRICAN AMERICAN WOMEN WITH 18%

7308
04:25:44,381 --> 04:25:49,653
OCCURRING IN HISPANIC LATINO

7309
04:25:49,653 --> 04:25:50,487
WOMEN.

7310
04:25:50,487 --> 04:25:52,289
TWO% OCCUR IN TRANSGENDER PEOPLE

7311
04:25:52,289 --> 04:25:54,491
WITH 76% OF PEOPLE OCCURRING IN

7312
04:25:54,491 --> 04:26:00,063
TRANSGENDER PEOPLE OF COLOR.

7313
04:26:00,063 --> 04:26:02,599
CRCHD, OHAN AND THE DIVISION OF

7314
04:26:02,599 --> 04:26:04,868
CANCER BIOLOGY HAVE BEEN

7315
04:26:04,868 --> 04:26:07,070
COLLABORATING IN EFFORTS THAT

7316
04:26:07,070 --> 04:26:10,674
INFORMED THE DEVELOPMENT OF

7317
04:26:10,674 --> 04:26:11,474
INITIATIVES, ADDRESSING

7318
04:26:11,474 --> 04:26:12,742
DISPARITIES, AND SOCIAL

7319
04:26:12,742 --> 04:26:13,877
DETERMINANTS OF HEALTH RESEARCH

7320
04:26:13,877 --> 04:26:18,815
IN CANCER AND PEOPLE WITH HIV.

7321
04:26:18,815 --> 04:26:21,985
THROUGH THE NCI'S EQUITY AND

7322
04:26:21,985 --> 04:26:23,753
INCLUSION PROGRAM, OHAM, CRCHD

7323
04:26:23,753 --> 04:26:31,695
AND THE OFFICE OF CANCER CENTERS

7324
04:26:31,695 --> 04:26:32,862
COLLABORATED TO DEVELOP

7325
04:26:32,862 --> 04:26:34,231
ADMINISTRATIVE SUPPLEMENTS TO

7326
04:26:34,231 --> 04:26:36,099
THE P30 CANCER CENTER WORK

7327
04:26:36,099 --> 04:26:36,466
GRANTS.

7328
04:26:36,466 --> 04:26:44,007
WE HAD QUITE A ROBUST NUMBER OF

7329
04:26:44,007 --> 04:26:45,642
APPLICATIONS WERE RECEIVED AND 6

7330
04:26:45,642 --> 04:26:47,644
AWARDS WERE MADE EMPLOY THE

7331
04:26:47,644 --> 04:26:50,814
PURPOSE OFLET RFA OR THE NOFO

7332
04:26:50,814 --> 04:26:53,683
WAS TO DEVELOP IRPT DISPRINCIPAL

7333
04:26:53,683 --> 04:26:55,485
DEPUTYARY TEAM, ESTABLISH

7334
04:26:55,485 --> 04:27:00,090
RESEARCH INFRASTRUCTURE AND

7335
04:27:00,090 --> 04:27:00,690
SUPPORT EXPLORATORY PROJECTS

7336
04:27:00,690 --> 04:27:01,992
SEEKING TO UNDERSTAND THE ROLE

7337
04:27:01,992 --> 04:27:03,660
OF DETERMINANTS OF HEALTH AND

7338
04:27:03,660 --> 04:27:04,995
CANCER CARE INIQUITIES AND

7339
04:27:04,995 --> 04:27:07,030
LEADING TO CANCER DISPARITIES IN

7340
04:27:07,030 --> 04:27:08,999
PEOPLE WITH HIV, AND WE FELT A

7341
04:27:08,999 --> 04:27:11,601
REALLY IMPORTANT ASPECT OF THESE

7342
04:27:11,601 --> 04:27:15,672
ADMINISTRATIVE SUPLEMS WAS THAT

7343
04:27:15,672 --> 04:27:17,307
WE HIGHLY ENCOURAGED

7344
04:27:17,307 --> 04:27:17,974
COLLABORATIVE EFFORTS BETWEEN

7345
04:27:17,974 --> 04:27:22,812
CANCER CENTERS AND CENTERS FOR

7346
04:27:22,812 --> 04:27:24,581
AIDS RESEARCH.

7347
04:27:24,581 --> 04:27:27,450
SO CRCHD AND DCB DEVELOPED AN

7348
04:27:27,450 --> 04:27:31,187
RFA FOCUSED ON BASIC AND

7349
04:27:31,187 --> 04:27:35,158
TRANSLATIONAL RESEARCH IN HEALTH

7350
04:27:35,158 --> 04:27:36,693
DISPARITIES WITH THE IDEA THAT

7351
04:27:36,693 --> 04:27:46,202
BOTH THAT RFA, AND THIS

7352
04:27:46,202 --> 04:27:47,537
NOFOWOULD ADDRESS ISSUES OF

7353
04:27:47,537 --> 04:27:48,571
CANCER DISPARITIES IN PEOPLE

7354
04:27:48,571 --> 04:27:51,541
WITH HIV BUT WITH DISTINCT

7355
04:27:51,541 --> 04:27:52,609
SCIENTIFIC GOALS.

7356
04:27:52,609 --> 04:27:54,010
ONE INITIATIVE FOCUSES ON BASIC

7357
04:27:54,010 --> 04:27:59,382
AND TRANSLATIONAL RESEARCH AND

7358
04:27:59,382 --> 04:28:00,984
THIS CURRENT CONCEPT WILL

7359
04:28:00,984 --> 04:28:04,354
ADDRESS SOCIAL DETERMINANTS OF

7360
04:28:04,354 --> 04:28:04,721
HEALTH.

7361
04:28:04,721 --> 04:28:07,957
DESPATE THE FACT THAT NCI'S

7362
04:28:07,957 --> 04:28:08,858
PRIORITIZED RESEARCH

7363
04:28:08,858 --> 04:28:09,926
INVESTIGATING CANCERS IN HIVE,

7364
04:28:09,926 --> 04:28:13,363
THERE'S BEEN A LIMITED PORTFOLIO

7365
04:28:13,363 --> 04:28:15,699
ON SOCIAL DETERMINANTS OF

7366
04:28:15,699 --> 04:28:16,700
HEALTH.

7367
04:28:16,700 --> 04:28:19,903
A PORTFOLIO ANALYSIS OF FISCAL

7368
04:28:19,903 --> 04:28:30,447
YEAR 2023, INDICATED THERE WERE

7369
04:28:33,650 --> 04:28:36,219
2 PAID GRANTS, 1 R01 GRANT IN

7370
04:28:36,219 --> 04:28:39,656
RESPONSE TO A P. A. R. AND 1 KOA

7371
04:28:39,656 --> 04:28:42,659
GRANT O THIS IS A EMILY THED

7372
04:28:42,659 --> 04:28:43,893
RESEARCH PORTFOLIO WITH SOCIAL

7373
04:28:43,893 --> 04:28:44,728
DETERMINANTS OF HEALTH AND

7374
04:28:44,728 --> 04:28:51,801
CANCERS WITH PEOPLE WITH HIV.

7375
04:28:51,801 --> 04:28:54,471
OH HAM AND CHCRD ARE PLANNING TO

7376
04:28:54,471 --> 04:28:57,941
LAGISTICALLY MANAGE THIS RFA AS

7377
04:28:57,941 --> 04:28:59,843
OHAP TYPICALLY MANAGES A

7378
04:28:59,843 --> 04:29:01,478
TRANSNCI INITIATIVE, WE HAVE AN

7379
04:29:01,478 --> 04:29:08,418
NCI WIDE TEAM PUT TOGETHER, LED

7380
04:29:08,418 --> 04:29:12,222
BY OHAM AND CHCRD, WILL KETERM

7381
04:29:12,222 --> 04:29:13,256
RESPONSIVENESS AND REFERRAL,

7382
04:29:13,256 --> 04:29:15,225
PREPARE A FUNDING PLAN TOGETHER

7383
04:29:15,225 --> 04:29:18,995
AND CONDUCT AN EVALUATION OF THE

7384
04:29:18,995 --> 04:29:19,362
PROGRAM.

7385
04:29:19,362 --> 04:29:22,565
APPLICATIONS WILL BE REFERRED

7386
04:29:22,565 --> 04:29:24,868
ACROSS ALL NCIDLCs ACCORDING

7387
04:29:24,868 --> 04:29:27,103
TO DEA REFERRAL GUIDELINES, AND

7388
04:29:27,103 --> 04:29:29,072
WE WERE ENCOURAGED BY RELATIVELY

7389
04:29:29,072 --> 04:29:32,041
ROBUST RESPONSE TO OUR CANCER

7390
04:29:32,041 --> 04:29:33,510
CENTERS ADMIN TRAITIVE

7391
04:29:33,510 --> 04:29:33,877
SUPPLEMENT NOFO.

7392
04:29:33,877 --> 04:29:37,580
WE FELT THAT THE APPLICATIONS

7393
04:29:37,580 --> 04:29:39,182
REPRESENTED STRONG TEEMS WITH A

7394
04:29:39,182 --> 04:29:42,185
GREAT TEAL OF INSTITUTIONAL

7395
04:29:42,185 --> 04:29:43,686
INFRASTRUCTURE IN SUPPORT TO

7396
04:29:43,686 --> 04:29:45,555
MOVE THIS AREA OF RESEARCH

7397
04:29:45,555 --> 04:29:47,190
FORWARD IN A LITTLE BIT MORE

7398
04:29:47,190 --> 04:29:50,560
AGGRESSIVE WAY THAN WE WERE

7399
04:29:50,560 --> 04:29:51,227
FIRST PLANNING.

7400
04:29:51,227 --> 04:29:54,664
SO INSTEAD OF DEVELOPING AN

7401
04:29:54,664 --> 04:29:56,065
EXPLORATORY GRANT MECHANISM SUCH

7402
04:29:56,065 --> 04:29:58,802
AS A P20, WE THOUGHT THAT A UO1

7403
04:29:58,802 --> 04:30:00,570
MECHANISM WILL BE MORE

7404
04:30:00,570 --> 04:30:00,904
APPROPRIATE.

7405
04:30:00,904 --> 04:30:04,974
THIS WILL ALLOW A PROGRAM STAFF

7406
04:30:04,974 --> 04:30:07,844
TO FACILITATE REGIONAL AND

7407
04:30:07,844 --> 04:30:08,511
INSTITUTIONAL COLLABORATIONS

7408
04:30:08,511 --> 04:30:13,583
BETWEEN HIV AND CANCER

7409
04:30:13,583 --> 04:30:13,883
RESEARCHERS.

7410
04:30:13,883 --> 04:30:14,984
WE'RE ALSO PLANNING ON

7411
04:30:14,984 --> 04:30:15,985
DEVELOPING A PRINCE PALE

7412
04:30:15,985 --> 04:30:18,588
INVESTIGATORS MEETING TO FOSTER

7413
04:30:18,588 --> 04:30:20,423
DISSEMINATION OF INFORMATION,

7414
04:30:20,423 --> 04:30:27,630
DISCUSS CHALLENGES AND IDENTIFY

7415
04:30:27,630 --> 04:30:29,065
OPPORTUNITIES FOR COLLABORATION.

7416
04:30:29,065 --> 04:30:30,633
SO OUR BUDGET REQUEST WOULD BE 3

7417
04:30:30,633 --> 04:30:34,838
RECEIPT DATES FOR FISCAL YEAR

7418
04:30:34,838 --> 04:30:37,941
25, 26, AND 27 WITH 3 TO 4 UO1S

7419
04:30:37,941 --> 04:30:39,642
FOR EACH RECEIPT DATE.

7420
04:30:39,642 --> 04:30:44,247
FOR UP TO 12 AWARDS TOTAL,

7421
04:30:44,247 --> 04:30:47,417
$3 MILLION INVESTED FOR EACH

7422
04:30:47,417 --> 04:30:48,251
FISCAL YEAR, WITH $15 MILLION

7423
04:30:48,251 --> 04:30:50,987
OVER ALL REQUESTED FOR 5 YEARS

7424
04:30:50,987 --> 04:30:59,863
FOR EACH OF 3 RECEIPT DATES,

7425
04:30:59,863 --> 04:31:00,430
TOTALING $45 MILLION.

7426
04:31:00,430 --> 04:31:04,267
NOW IS THE CASE WITH MANY OHAM

7427
04:31:04,267 --> 04:31:06,102
PROJECTINGS, FUNDING WILL COME

7428
04:31:06,102 --> 04:31:08,004
FROM AIDS FUNDS RECEIVED THROUGH

7429
04:31:08,004 --> 04:31:09,939
THE OFFICE OF AIDS RESEARCH OR

7430
04:31:09,939 --> 04:31:11,841
O. A. R. AND THE CONCEPT HAS

7431
04:31:11,841 --> 04:31:14,110
BEEN REVIEWED BY THE OFFICE OF

7432
04:31:14,110 --> 04:31:19,449
AID RESEARCH AND KEEM

7433
04:31:19,449 --> 04:31:19,782
AIDS-ALIGNED.

7434
04:31:19,782 --> 04:31:20,750
SO AT THIS POINT I WOULD BE

7435
04:31:20,750 --> 04:31:31,227
HAPPY TO TAKE ANY QUESTIONS.

7436
04:31:32,128 --> 04:31:32,428
>> ANNA MARIA?

7437
04:31:32,428 --> 04:31:33,396
>> THANK YOU TO THE
DOCTORS WHO

7438
04:31:33,396 --> 04:31:38,401
MET WITH US AND TO MY TEAM

7439
04:31:38,401 --> 04:31:39,802
MEMBERS DR. [INDISCERNIBLE] AND

7440
04:31:39,802 --> 04:31:41,771
DR. ROBERTON, WE HAD A LOT OF

7441
04:31:41,771 --> 04:31:43,840
ENTHUSIASM FOR THIS PROPOSAL,

7442
04:31:43,840 --> 04:31:45,808
VERY MUCH APPRECIATED THAT IT IS

7443
04:31:45,808 --> 04:31:52,448
A TRANSNCI EFFORT AND

7444
04:31:52,448 --> 04:31:53,917
COLLABORATION AND THAT THE WORK

7445
04:31:53,917 --> 04:31:55,118
IN TRYING TO UNDERSTAND CANCER

7446
04:31:55,118 --> 04:31:56,085
IN PEOPLE WITH HIV IS

7447
04:31:56,085 --> 04:31:57,020
NONAPOPTOTIC THE NEW.  THIS IS

7448
04:31:57,020 --> 04:31:59,556
SOMETHING THAT HAS BEEN IN PLACE

7449
04:31:59,556 --> 04:32:04,160
BUT THIS IS REALLY THINKING MORE

7450
04:32:04,160 --> 04:32:06,129
BROADLY, NOT JUST WHAT CANCERS

7451
04:32:06,129 --> 04:32:08,998
ARE ASSOCIATED WITH HIV, BUT

7452
04:32:08,998 --> 04:32:12,502
CANCERS IN PERSONS WITH HIV.

7453
04:32:12,502 --> 04:32:15,772
AND AS ROBIN MENTIONED EARLIER,

7454
04:32:15,772 --> 04:32:17,774
THE DEMOGRAPHICS ARE CHANGING SO

7455
04:32:17,774 --> 04:32:20,877
WE NEED TO BE THINKING ABOUT

7456
04:32:20,877 --> 04:32:23,613
LUNG CANCER FOR EXAMPLE, SO VERY

7457
04:32:23,613 --> 04:32:26,816
IMPORTANT AREA TO FOCUS ON.

7458
04:32:26,816 --> 04:32:27,884
ALSO OUTLINING CAREFULLY THAT

7459
04:32:27,884 --> 04:32:30,653
THERE ARE MULTIPLE FACTORS HERE,

7460
04:32:30,653 --> 04:32:33,523
PATIENT FACTORS, CLINICIAN

7461
04:32:33,523 --> 04:32:34,591
FACTORS COMMUNITY FACTORS,

7462
04:32:34,591 --> 04:32:36,726
HEALTH SYSTEM FACTORS, BUT THAT

7463
04:32:36,726 --> 04:32:38,361
WITHIN ALL OF THAT ARE THE

7464
04:32:38,361 --> 04:32:40,563
SOCIAL DETERMINANTS OF WHAT I

7465
04:32:40,563 --> 04:32:43,633
SAY OF ILLNESS, AND THESE ARE

7466
04:32:43,633 --> 04:32:45,935
COMPLEX, THEY INTERSECT AND THEY

7467
04:32:45,935 --> 04:32:47,537
REINFORCE AS YOU MENTIONED.

7468
04:32:47,537 --> 04:32:50,073
SO YEE NEED TO BETTER UNDERSTAND

7469
04:32:50,073 --> 04:32:52,475
THESE STRUCTURES, UNDERSTAND THE

7470
04:32:52,475 --> 04:32:53,543
MULTILEVEL SOLUTIONS, AND THAT

7471
04:32:53,543 --> 04:32:56,245
WILL REALLY HELP US TO PROGRESS

7472
04:32:56,245 --> 04:32:59,582
IN AN AREA WHERE THERE IS A VERY

7473
04:32:59,582 --> 04:33:00,049
LIMITED PORTFOLIO.

7474
04:33:00,049 --> 04:33:02,719
SO WE WERE VERY ENTHUSIASTIC AND

7475
04:33:02,719 --> 04:33:07,357
VERY SUPPORTIVE OF THIS CONCEPT.

7476
04:33:07,357 --> 04:33:13,796
I TURN TO MY CO-TEAM. 

7477
04:33:13,796 --> 04:33:14,263
>> YEAH, I CONCUR.

7478
04:33:14,263 --> 04:33:19,569
I THINK TO ADD ON TO WHAT ANNA

7479
04:33:19,569 --> 04:33:21,270
MARIA SAID IS FURTHER STRENGTH

7480
04:33:21,270 --> 04:33:22,905
OF THIS IS IT'S NOT JUST CANCER

7481
04:33:22,905 --> 04:33:24,874
TREATMENT BUT IT'S ALSO CANCER

7482
04:33:24,874 --> 04:33:26,075
KREENING AND HOW SOCIAL

7483
04:33:26,075 --> 04:33:27,744
DETERMINANTS OF HEALTH AND

7484
04:33:27,744 --> 04:33:29,278
PERSONS WITH HIV INTERACT WITH

7485
04:33:29,278 --> 04:33:33,916
THOSE, WITH THE WHOLE CONTINUUM

7486
04:33:33,916 --> 04:33:39,455
OF CANCER CARE.

7487
04:33:39,455 --> 04:33:40,423
>> EARL?

7488
04:33:40,423 --> 04:33:42,325
>> THANK YOU. 

7489
04:33:42,325 --> 04:33:43,459
THANK YOU REBECCA.

7490
04:33:43,459 --> 04:33:45,194
THIS IS A GREAT PROGRAM, I THINK

7491
04:33:45,194 --> 04:33:46,596
THERE WILL BE A LOT THAT WE CAN

7492
04:33:46,596 --> 04:33:48,698
LEARN FROM THE WAY THIS IS SET

7493
04:33:48,698 --> 04:33:48,865
UP.

7494
04:33:48,865 --> 04:33:51,567
THANK YOU FOR ADDRESSING THE

7495
04:33:51,567 --> 04:33:53,870
QUESTIONS THAT WE HAD I THINK IT

7496
04:33:53,870 --> 04:33:58,675
HIGHLIGHTED A NUMBER OF AREAS

7497
04:33:58,675 --> 04:34:01,144
THAT REALLY IS CRITICAL FOR

7498
04:34:01,144 --> 04:34:03,279
UNDERSTANDING DETERMINANT OF

7499
04:34:03,279 --> 04:34:06,049
INDIVIDUALS OF HIV POSITIVE AND

7500
04:34:06,049 --> 04:34:07,650
ALSO EXPERIENCING CANCER.

7501
04:34:07,650 --> 04:34:09,285
AND I THINK AS WE GO FORWARD, I

7502
04:34:09,285 --> 04:34:11,354
THINK THIS PROGRAM WILL REALLY

7503
04:34:11,354 --> 04:34:13,990
HELP US UNDERSTAND HOW THESE

7504
04:34:13,990 --> 04:34:15,291
INDIVIDUALS ARE DEALING

7505
04:34:15,291 --> 04:34:16,359
WITH--WHAT THESE INDIVIDUALS ARE

7506
04:34:16,359 --> 04:34:17,860
DEALING WITH IN TERMS OF THE

7507
04:34:17,860 --> 04:34:19,395
SOCIAL ASPECT OF IT BUT MORE SO

7508
04:34:19,395 --> 04:34:24,901
HOW WE CAN ACTUALLY HELP THEM

7509
04:34:24,901 --> 04:34:26,536
THAT THE BASIC STRUCTURAL

7510
04:34:26,536 --> 04:34:27,603
PROBLEMS THAT THEY'RE FACING IN

7511
04:34:27,603 --> 04:34:31,908
SOCIAL VIERPTS SO THANK YOU FOR

7512
04:34:31,908 --> 04:34:35,478
DOING THAT.

7513
04:34:35,478 --> 04:34:35,912
>> [INDISCERNIBLE]

7514
04:34:35,912 --> 04:34:37,447
>> THERE'S NOTHING THAT
GETS

7515
04:34:37,447 --> 04:34:39,115
EXCITING MORE THAN SOCIAL

7516
04:34:39,115 --> 04:34:39,949
DETERMINANTS OF HEALTH.

7517
04:34:39,949 --> 04:34:41,184
JUST A COUPLE THOUGHTS AS

7518
04:34:41,184 --> 04:34:43,152
SOMEONE WHO LIVES IN THAT WORLD,

7519
04:34:43,152 --> 04:34:46,389
SO I THINK THERE ARE LOTS OF

7520
04:34:46,389 --> 04:34:48,124
CONCEPTUAL MODELS AROUND SOCIAL

7521
04:34:48,124 --> 04:34:48,958
DETERMINANTS OF HEALTH AND I

7522
04:34:48,958 --> 04:34:50,393
THINK IT'S IMPORTANT FOR THIS

7523
04:34:50,393 --> 04:34:52,528
RFOOTWORKA TO CONSIDER, BUT THE

7524
04:34:52,528 --> 04:34:54,063
CORE I'M THINK BEING IN MY HEAD

7525
04:34:54,063 --> 04:34:57,200
IS W. H. O. MODEL AROUND SOCIAL

7526
04:34:57,200 --> 04:34:57,867
DETERMINANTS OF HEALTH.

7527
04:34:57,867 --> 04:34:59,736
I THINK THE OVERTIME THE

7528
04:34:59,736 --> 04:35:01,504
THINKING HAS EVOLVED SO THAT YOU

7529
04:35:01,504 --> 04:35:02,572
THINK ABOUT STRUCTURAL

7530
04:35:02,572 --> 04:35:05,241
DETERMINANTS AND THEN THE SOCIAL

7531
04:35:05,241 --> 04:35:07,777
DETERMINANTS AND HELT CARE

7532
04:35:07,777 --> 04:35:08,711
DETERMINANTS, FOR THIS BROAD LYE

7533
04:35:08,711 --> 04:35:11,414
TO GET WHAT CALLED THEM ALL

7534
04:35:11,414 --> 04:35:12,315
SOCIAL DETERMINANTS, REASON I

7535
04:35:12,315 --> 04:35:14,183
SAY SO IS THAT WHY WE THINK

7536
04:35:14,183 --> 04:35:17,120
ABOUT IT, IT HAD MULTIPLE

7537
04:35:17,120 --> 04:35:18,521
FACTORS THAT CONTRIBUTE TO A

7538
04:35:18,521 --> 04:35:19,956
FABLGHTOR THAT CONTRIBUTE SOCIAL

7539
04:35:19,956 --> 04:35:22,125
DETERMINANTS, AND I AM ACTUALLY

7540
04:35:22,125 --> 04:35:24,093
YET TO SEE SOMEBODY WHO ACTUALLY

7541
04:35:24,093 --> 04:35:26,295
HAS 1 SOCIAL DETERMINANTS OF

7542
04:35:26,295 --> 04:35:27,797
HEALTH OR SOCIAL FACTOR.

7543
04:35:27,797 --> 04:35:30,199
WE KREEN AND WE FIND MULTIPLE

7544
04:35:30,199 --> 04:35:31,400
THINGS IN INDIVIDUALS TO DIG

7545
04:35:31,400 --> 04:35:32,802
DEEPER INTO IT, BUT THE POINT

7546
04:35:32,802 --> 04:35:35,571
I'M GETTING TO IS THAT THERE MAY

7547
04:35:35,571 --> 04:35:37,106
BE A HIERARCHY TOWARD THE

7548
04:35:37,106 --> 04:35:39,842
FACTORS, IF YOU THINK ABOUT

7549
04:35:39,842 --> 04:35:41,277
EDUCATION ASSAY, NATIONAL

7550
04:35:41,277 --> 04:35:45,348
PROXIMAL FACTOR THAT LEADS TO

7551
04:35:45,348 --> 04:35:45,982
UTILITIES AND PERSONAL BALANCE

7552
04:35:45,982 --> 04:35:48,317
AND I THINK HAPPENING THINK

7553
04:35:48,317 --> 04:35:49,318
ABOUT HOW THOSE ARE IMPORTANT

7554
04:35:49,318 --> 04:35:55,258
BUT ALSO I THINK THE CONCEPT OF

7555
04:35:55,258 --> 04:35:58,261
SOCIAL DETERMINANTS IS BROAD AND

7556
04:35:58,261 --> 04:36:00,997
DEVALUE ON HOW YOU ALLOW FOR

7557
04:36:00,997 --> 04:36:04,200
LATITUDE BUT ALSO SUBMIT TO MORE

7558
04:36:04,200 --> 04:36:06,936
PRESCRIPTIVE OR GUIDANCE PEOPLE,

7559
04:36:06,936 --> 04:36:07,570
RESPECTFUL CARE SOCIAL

7560
04:36:07,570 --> 04:36:10,273
DETERMINANTS, SO THERE WAS A

7561
04:36:10,273 --> 04:36:11,607
SORT OF HAD IN MY HEAD AND I

7562
04:36:11,607 --> 04:36:17,280
WANT TO SHARE THAT WITH YOU TO

7563
04:36:17,280 --> 04:36:17,647
CONSIDER.

7564
04:36:17,647 --> 04:36:18,347
IN, ANDREA.

7565
04:36:18,347 --> 04:36:21,317
NYES, I WANTED TO SART OF ADD TO

7566
04:36:21,317 --> 04:36:22,852
THAT, THOSE TOOK SOME PART OF MY

7567
04:36:22,852 --> 04:36:24,120
QUESTION, BUT WHEN YOU ARE

7568
04:36:24,120 --> 04:36:28,991
TALKING ABOUT SPECIFIC SOCIAL

7569
04:36:28,991 --> 04:36:30,359
DETERMINANTS OF HEALTH I THINK

7570
04:36:30,359 --> 04:36:32,361
IT'S IMPORTANT TO MAKE SURE

7571
04:36:32,361 --> 04:36:33,663
THAT'S BROADLY DEFINED TO MAKE

7572
04:36:33,663 --> 04:36:35,064
SURE FOLKS ARE NOT OHM THINKING

7573
04:36:35,064 --> 04:36:37,633
ABOUT FOOD SIN E CURITYS BUT

7574
04:36:37,633 --> 04:36:38,935
ALSO THINKING ABOUT SLEEP

7575
04:36:38,935 --> 04:36:41,904
DEPRIVATION AND HOW THOSE ARE

7576
04:36:41,904 --> 04:36:43,272
COMPLEXLY ADDITIVE OR

7577
04:36:43,272 --> 04:36:44,640
MULTIPLICATIVE IN CAUSING STRESS

7578
04:36:44,640 --> 04:36:49,812
AND CANCER AND THERE'S SOME VERY

7579
04:36:49,812 --> 04:36:51,214
RECENT STUDIES THAT SHOW IF YOU

7580
04:36:51,214 --> 04:36:52,615
TAKE MICE AND YOU DEPRIVE THEM

7581
04:36:52,615 --> 04:36:55,918
OF FOOD AND GIVE THEM FOOD

7582
04:36:55,918 --> 04:36:57,887
INSECURITY THEN THE TUMOR

7583
04:36:57,887 --> 04:36:59,755
TRIPLES IN SIZE, SO THIS IS A

7584
04:36:59,755 --> 04:37:01,023
REALLY CRITICAL STUDY TO TRY TO

7585
04:37:01,023 --> 04:37:02,625
GET AS MUCH INFORMATION AS

7586
04:37:02,625 --> 04:37:04,460
POSSIBLE IN A VERY BROAD

7587
04:37:04,460 --> 04:37:05,628
DEFINITION OF SOCIAL

7588
04:37:05,628 --> 04:37:06,829
DETERMINANTS OF HEALTH SO THOSE

7589
04:37:06,829 --> 04:37:08,331
INDIVIDUAL TYPES OF STRESSORS

7590
04:37:08,331 --> 04:37:13,002
CAN BE TEASED OUT.

7591
04:37:13,002 --> 04:37:14,270
NYES, FANTASTIC, AND KIND OF

7592
04:37:14,270 --> 04:37:15,471
OVERVIEW, THIS IS A GREAT TOPIC

7593
04:37:15,471 --> 04:37:18,441
AND I DO THINK IT MIGHT BE ABLE

7594
04:37:18,441 --> 04:37:21,344
TO BE A PRACTICAL APPLICATION OF

7595
04:37:21,344 --> 04:37:22,445
THE NIH WIDE COMMISSION ON

7596
04:37:22,445 --> 04:37:23,613
THINKING ABOUT SOCIAL DETERMINE

7597
04:37:23,613 --> 04:37:24,914
NABTS OF HEALTH I'M SURE YOU

7598
04:37:24,914 --> 04:37:26,749
PROBABLY DISCUSS THAT, I THINK

7599
04:37:26,749 --> 04:37:31,554
THERE NEED TOTION BE A COMMON

7600
04:37:31,554 --> 04:37:32,021
 COMMON

7601
04:37:32,021 --> 04:37:32,955
DEFINITION, AND THEN ALSO REALLY

7602
04:37:32,955 --> 04:37:33,923
THINKING ABOUT THE DIFFERENCE

7603
04:37:33,923 --> 04:37:35,558
BETWEEN HEALTH AND RELATED

7604
04:37:35,558 --> 04:37:37,059
SOCIAL NEEDS RIGHT, VERSUS

7605
04:37:37,059 --> 04:37:38,594
SOCIAL DETERMINANTS WITH OFTEN

7606
04:37:38,594 --> 04:37:39,662
TIMES THAT ARE UPSTREAM SO LIKE

7607
04:37:39,662 --> 04:37:41,530
WHEN IT CAME TO THE THIRD BULLET

7608
04:37:41,530 --> 04:37:43,299
AND THINKING ABOUT THE RESEARCH

7609
04:37:43,299 --> 04:37:46,602
SCOPE, WE'RE TALKING ABOUT

7610
04:37:46,602 --> 04:37:47,937
RESEARCH IDENTIFYING AND TESTING

7611
04:37:47,937 --> 04:37:50,573
STRATEGIES TO,A LEAVEIATE SOCIAL

7612
04:37:50,573 --> 04:37:51,974
DETERMINANTS WAS IT REALLY

7613
04:37:51,974 --> 04:37:53,242
LOOKING AT SOCIAL DETERMINE

7614
04:37:53,242 --> 04:37:55,378
NABTS OR HEALTH SOCIAL NEEDS.

7615
04:37:55,378 --> 04:38:05,922
>> SORRY, HEALTH RELATED
WHAT?

7616
04:38:06,289 --> 04:38:06,989
>> SOCIAL NEEDS?

7617
04:38:06,989 --> 04:38:11,294
>> I THINK AS WE WERE
MOVING

7618
04:38:11,294 --> 04:38:17,066
THROUGH THIS, WE WERE TALKING

7619
04:38:17,066 --> 04:38:19,402
ABOUT--SO, SAY POVERTY OR

7620
04:38:19,402 --> 04:38:23,005
SOCIOECONOMIC STATUS, HOW WOULD

7621
04:38:23,005 --> 04:38:24,840
YOU ADDRESS, I CAN BE THE

7622
04:38:24,840 --> 04:38:26,409
ADDRESS A PERSON'S SOCIOECONOMIC

7623
04:38:26,409 --> 04:38:28,077
STATUS BUT IN THE CASE OF SOME

7624
04:38:28,077 --> 04:38:32,615
OF THE CLINICAL TRIALS THAT I'VE

7625
04:38:32,615 --> 04:38:35,351
BEEN INVOLVED WITH, WE CAN HELP

7626
04:38:35,351 --> 04:38:40,222
THE PEOPLE GET TO THE CLINICAL

7627
04:38:40,222 --> 04:38:41,390
TRIAL BY PROVIDING

7628
04:38:41,390 --> 04:38:42,325
TRANSPORTATION COSTS OR THINGS

7629
04:38:42,325 --> 04:38:45,194
LIKE THAT, AND SO I THINK THAT

7630
04:38:45,194 --> 04:38:51,400
IS HOW WE MIGHT WORK AND

7631
04:38:51,400 --> 04:38:54,670
ENCOURAGE SITES TO EXPLORE THOSE

7632
04:38:54,670 --> 04:38:59,241
TYPES OF OPTIONS TO ALLEVIATE

7633
04:38:59,241 --> 04:39:02,178
THE PROBLEM THAT RESULTS FROM

7634
04:39:02,178 --> 04:39:03,312
THE SOCIAL DETERMINANTS, DOES

7635
04:39:03,312 --> 04:39:04,447
THAT ANSWER YOUR QUESTION.

7636
04:39:04,447 --> 04:39:05,715
>> I THINK THAT'S MORE
HEALTH

7637
04:39:05,715 --> 04:39:06,148
RELATED SOCIAL NEED

7638
04:39:06,148 --> 04:39:06,682
SPECIALIZATION OF SPECIFIC

7639
04:39:06,682 --> 04:39:07,283
ENDOTHELIAL I WOULD LOOK AT

7640
04:39:07,283 --> 04:39:08,384
LANGUAGE BECAUSE THERE IS A

7641
04:39:08,384 --> 04:39:09,218
DIFFERENCE BETWEEN SOCIAL

7642
04:39:09,218 --> 04:39:10,252
DETERMINE NABTS OF HEALTH,

7643
04:39:10,252 --> 04:39:12,321
SOCIAL RISK AND HEALTH RELATED

7644
04:39:12,321 --> 04:39:14,557
SOCIAL NEED AND THAT WILL IMPACT

7645
04:39:14,557 --> 04:39:15,858
WHAT THE OUTCOME IS GOING TO BE,

7646
04:39:15,858 --> 04:39:17,293
BECAUSE IF YOU SAY YOU WANT

7647
04:39:17,293 --> 04:39:19,695
PEOPLE TO ALLEVIATE SOME OF THE

7648
04:39:19,695 --> 04:39:20,863
SOCIAL DETERMINANTS OF HEALTH,

7649
04:39:20,863 --> 04:39:23,165
JUST BECAUSE YOU SAID

7650
04:39:23,165 --> 04:39:24,433
SOCIOECONOMIC STATUS WILL NOT

7651
04:39:24,433 --> 04:39:26,168
CHANGE, IN THE LANGUAGE.

7652
04:39:26,168 --> 04:39:30,106
>> LANGUAGE MATTERS NTHANK
YOU,

7653
04:39:30,106 --> 04:39:30,439
YES.

7654
04:39:30,439 --> 04:39:32,742
NANYONE DOWN THERE AT THAT END

7655
04:39:32,742 --> 04:39:34,543
OF THE TABLE?

7656
04:39:34,543 --> 04:39:35,911
>> QUICK QUESTION, ON PAGE
7 OF

7657
04:39:35,911 --> 04:39:37,246
THE SLIDE, I WAS WONDERING IF

7658
04:39:37,246 --> 04:39:47,623
YOU CAN BRING IT UP AGAIN EMPLOY

7659
04:39:47,623 --> 04:39:50,059
I THINK IT JUST HELPS BECAUSE

7660
04:39:50,059 --> 04:39:50,860
THERE'S SEVERAL INDIVIDUALS

7661
04:39:50,860 --> 04:39:52,395
AIER, I WANT TO KNOW HOW THIS

7662
04:39:52,395 --> 04:39:53,496
WOULD BE DIFFERENT THAN ALL

7663
04:39:53,496 --> 04:39:54,697
THOSE HUNDREDS AND HUNDREDS OF

7664
04:39:54,697 --> 04:39:56,432
STUDIES WE'VE DONE EVERY YEAR,

7665
04:39:56,432 --> 04:39:57,833
FOR DECADES ON THAT SLIDE AND SO

7666
04:39:57,833 --> 04:40:08,310
THAT'S WHAT I WAS CURIOUS TO

7667
04:40:08,677 --> 04:40:09,145
KNOW ABOUT.

7668
04:40:09,145 --> 04:40:15,351
I THINK YOU JUST ANSWERED THE

7669
04:40:15,351 --> 04:40:15,618
QUESTION.

7670
04:40:15,618 --> 04:40:19,255
>> OH SURE, I WAS CURIOUS
TO

7671
04:40:19,255 --> 04:40:21,657
KNOW, MY PERSPECTIVE WAS, YOU

7672
04:40:21,657 --> 04:40:23,125
HAD MENTIONED 32,000 NEW

7673
04:40:23,125 --> 04:40:25,061
INFECTIONS PER YEAR, AND I SEE

7674
04:40:25,061 --> 04:40:26,862
SINCE 2014, YOU'VE HAD ALL THESE

7675
04:40:26,862 --> 04:40:29,565
DISDS, I WANTED TO KNOW WHAT THE

7676
04:40:29,565 --> 04:40:34,703
STUDY WAS DIFFERENT THAN-

7677
04:40:34,703 --> 04:40:36,839
>> THESE AREN'T--THE BLUE
IS THE

7678
04:40:36,839 --> 04:40:38,107
APPLICATIONS, ORANGE IS THE

7679
04:40:38,107 --> 04:40:40,309
AWARD, THESE ARE JUST HIV AND

7680
04:40:40,309 --> 04:40:45,514
CANCER AWARDS THEY DON'T ENTAIL

7681
04:40:45,514 --> 04:40:47,983
SOCIAL DETERMINANTS OF HEALTH.

7682
04:40:47,983 --> 04:40:52,421
>> WELL IT SAYS HEALTH

7683
04:40:52,421 --> 04:40:55,858
DISPARITIES AS WELL NTHE YELLOW

7684
04:40:55,858 --> 04:40:58,994
BAR, AND SOME YEARS IT'S 0.

7685
04:40:58,994 --> 04:40:59,962
>> AND SO THOSE 1S IN
ORANGE

7686
04:40:59,962 --> 04:41:03,265
THEY ONLY LOOK AT HIV AND CANCER

7687
04:41:03,265 --> 04:41:08,504
THEY NEVER LOOKED AT--NETWORK

7688
04:41:08,504 --> 04:41:09,605
NO, THAT'S OUR--

7689
04:41:09,605 --> 04:41:11,373
>> I WOULDN'T SAY IGNORE
IT,

7690
04:41:11,373 --> 04:41:13,275
THEY'RE JUST ADDRESSING

7691
04:41:13,275 --> 04:41:14,343
DIFFERENT QUESTIONS.

7692
04:41:14,343 --> 04:41:15,277
THEY CAN MEET THE CANCER THR

7693
04:41:15,277 --> 04:41:16,479
ACTIVITIES AND PROJECTSY, IT CAN

7694
04:41:16,479 --> 04:41:18,747
BE BASIC RESEARCH, THAT'S ACROSS

7695
04:41:18,747 --> 04:41:22,084
THE BOARD FOR NCI'S HIV CANCER.

7696
04:41:22,084 --> 04:41:22,751
>> THANK YOU.

7697
04:41:22,751 --> 04:41:27,990
>> CAN I HAVE A MOTION?

7698
04:41:27,990 --> 04:41:32,995
>> MOVE TO APPROVE.

7699
04:41:32,995 --> 04:41:33,496
>> SECOND.

7700
04:41:33,496 --> 04:41:35,297
>> OKAY, ANY FURTHER

7701
04:41:35,297 --> 04:41:35,598
DISCUSSION,.

7702
04:41:35,598 --> 04:41:38,033
>> I WILL BE A NAY.

7703
04:41:38,033 --> 04:41:38,667
>> OKAY.

7704
04:41:38,667 --> 04:41:41,370
ARE THERE ANY ABSTENTIONS?

7705
04:41:41,370 --> 04:41:43,939
>>  OKAY, SO WE HAVE 1
NAY.

7706
04:41:43,939 --> 04:41:44,173
DPRAIT.

7707
04:41:44,173 --> 04:41:46,175
>> THAIRK YOU.

7708
04:41:46,175 --> 04:41:47,076
OKAY.

7709
04:41:47,076 --> 04:41:49,612
THEN THE NEXT PRESENTATION WILL

7710
04:41:49,612 --> 04:41:52,114
BE BY MICHAEL SCHMITT BUT HE

7711
04:41:52,114 --> 04:41:54,750
WILL BE VIRTUAL, THE NCI PATHWAY

7712
04:41:54,750 --> 04:42:01,290
TO INDEPENDENT AWARD THE K99 R00

7713
04:42:01,290 --> 04:42:03,292
AND OUR COMMITTEE IS JENNIFER,

7714
04:42:03,292 --> 04:42:06,896
TRAY AND SYLVIA, MICHAEL?

7715
04:42:06,896 --> 04:42:07,863
>> OKAY, THANK YOU AND
GOOD

7716
04:42:07,863 --> 04:42:10,799
AFTERNOON AND THANK YOU FOR THE

7717
04:42:10,799 --> 04:42:12,067
OPPORTUNITY TO PRESENT THIS

7718
04:42:12,067 --> 04:42:15,738
CONCEPT, AND I WOULD LIKE TO

7719
04:42:15,738 --> 04:42:19,608
SPECIALLY THANK OUR REVIEWERS,

7720
04:42:19,608 --> 04:42:22,778
[INDISCERNIBLE] FOR REALLY

7721
04:42:22,778 --> 04:42:24,480
HELPFUL DISCUSSIONS AND

7722
04:42:24,480 --> 04:42:25,247
INSIGHTFUL COMMENTS.

7723
04:42:25,247 --> 04:42:26,315
THOUGH IN MY PRESENTATION, I

7724
04:42:26,315 --> 04:42:33,822
WANT TO GIVE YOU AN OVERVIEW OF

7725
04:42:33,822 --> 04:42:37,293
THE K99 R00 BRIEFLY PRESENT DATA

7726
04:42:37,293 --> 04:42:39,261
FROM OUR RECENT EVALUATION OF

7727
04:42:39,261 --> 04:42:40,963
THE OUTCOMES OF THIS MECHANISM

7728
04:42:40,963 --> 04:42:51,340
AND THEN PROPOSE OUR NEW NCI

7729
04:42:51,340 --> 04:42:55,344
SPECIFIC K99 R00, NCEYE K99

7730
04:42:55,344 --> 04:42:57,479
ROOPAR, IT IS TO HELP

7731
04:42:57,479 --> 04:42:59,014
OUTSTANDING POST DOCTORAL

7732
04:42:59,014 --> 04:43:02,384
STUDENTORERAL SCALERS TO

7733
04:43:02,384 --> 04:43:07,189
COMPLETE NEEDED MENTOR TRAINING

7734
04:43:07,189 --> 04:43:10,226
CAN TO HELP THEM, AS A TENURED

7735
04:43:10,226 --> 04:43:15,431
TRACK PROFESSOR IN A TIMELY

7736
04:43:15,431 --> 04:43:15,998
MANNER.

7737
04:43:15,998 --> 04:43:18,767
THE K99 ROO IS OUR ONLY CAREER

7738
04:43:18,767 --> 04:43:20,336
DEVELOPMENT AWARD THAT IS OPEN

7739
04:43:20,336 --> 04:43:24,473
BOTH TO YOU AS CITIZEN, AND NONE

7740
04:43:24,473 --> 04:43:25,407
U.S. CITIZEN.

7741
04:43:25,407 --> 04:43:29,011
NO APPLICANTS FOR THE K99 MUST

7742
04:43:29,011 --> 04:43:31,513
BE A MENTORED NONINDEPENDENT

7743
04:43:31,513 --> 04:43:32,881
POSITION, AND APPLICANTS MUST

7744
04:43:32,881 --> 04:43:36,018
HAVE NO MORE THAN 4IERS OF POST

7745
04:43:36,018 --> 04:43:41,156
DOCTORAL RESEARCH TRAINING

7746
04:43:41,156 --> 04:43:41,690
EXPERIENCE.

7747
04:43:41,690 --> 04:43:44,793
AT NCI WE SUPPORT ALL AREA OF

7748
04:43:44,793 --> 04:43:48,697
CANCER RESEARCH, VERY THE K99

7749
04:43:48,697 --> 04:43:49,198
R00.

7750
04:43:49,198 --> 04:43:51,200
WE HAVE RECEIVED TYPICALLY ARK

7751
04:43:51,200 --> 04:43:54,503
ROUND 200 APPLICATIONS PER YEAR.

7752
04:43:54,503 --> 04:43:56,238
AND OUR FINANCIAL COMMITMENT IN

7753
04:43:56,238 --> 04:44:00,242
THE PAST 5 YEARS HAS BEEN

7754
04:44:00,242 --> 04:44:04,079
RELATIVELY CONSISTENT AT ABOUT

7755
04:44:04,079 --> 04:44:14,623
$6.5 MILLION PER YEAR.

7756
04:44:14,623 --> 04:44:16,692
THE SUCCESS RATE IS AT ABOUT

7757
04:44:16,692 --> 04:44:19,328
59%, SO IT'S FAIRLY COMPETITOR

7758
04:44:19,328 --> 04:44:20,029
MECHANISM.

7759
04:44:20,029 --> 04:44:22,931
WE HAVE RECENTLY EVALUATED THE

7760
04:44:22,931 --> 04:44:27,169
OUTCOMES FOR THE NCI PARENT K99

7761
04:44:27,169 --> 04:44:30,039
R00 PROGRAM AND I THINK OUR DATA

7762
04:44:30,039 --> 04:44:34,710
SUGGESTS THAT THIS AWARD IS,

7763
04:44:34,710 --> 04:44:36,245
WOWORKING AT INTENDED.

7764
04:44:36,245 --> 04:44:37,846
IT FACILITATES SUCCESSFULLY THE

7765
04:44:37,846 --> 04:44:41,350
TRANSITION OF POST DOCTORAL

7766
04:44:41,350 --> 04:44:42,518
[INDISCERNIBLE] INDEPENDENCE AND

7767
04:44:42,518 --> 04:44:45,721
ENHANCING THE LIKELIHOOD OF K99

7768
04:44:45,721 --> 04:44:50,759
AWARDEES TO SECURE RO-1 OR RO-1

7769
04:44:50,759 --> 04:44:55,964
LIKE GRANTS AWARD.

7770
04:44:55,964 --> 04:44:58,967
ABOUT 90% OF K99S TRANSITION TO

7771
04:44:58,967 --> 04:45:02,504
INDEPENDENCE AND AROUND 65% OF

7772
04:45:02,504 --> 04:45:06,475
K99 AWARDEES ARE ABLE TO SECURE

7773
04:45:06,475 --> 04:45:09,678
R01 EQUIVALENT GRANT SUPPORT.

7774
04:45:09,678 --> 04:45:13,082
WE ALSO OBSERVED THAT SEX OR

7775
04:45:13,082 --> 04:45:14,950
GENDER AS WELL AS RACE AND EGHT

7776
04:45:14,950 --> 04:45:17,653
INISSITY HAD NO SIGNIFICANT

7777
04:45:17,653 --> 04:45:21,123
IMPACT, EITHER ON THE TRANSITION

7778
04:45:21,123 --> 04:45:24,460
RATES OR ON THE R01 AWARD RATES.

7779
04:45:24,460 --> 04:45:26,929
SO THIS MEANS THIS AWARD IS

7780
04:45:26,929 --> 04:45:27,930
WORKING FOR EVERYBODY.

7781
04:45:27,930 --> 04:45:31,300
IT IS AN IMPORTANT TOOL FOR

7782
04:45:31,300 --> 04:45:32,368
WORKFORCE DEVELOPMENT.

7783
04:45:32,368 --> 04:45:36,472
WE HAVE RECENTLY PUBLISHED THE

7784
04:45:36,472 --> 04:45:37,906
RESULTS OF THE STUDY IN THE

7785
04:45:37,906 --> 04:45:39,742
YOWRNAL OF CANCER EDUCATION AND

7786
04:45:39,742 --> 04:45:44,179
1 COMPONENT OF THIS STUDY HAD

7787
04:45:44,179 --> 04:45:49,518
AURE VEY AND INTERVIEW WITH K99

7788
04:45:49,518 --> 04:45:52,254
APPLICANTS, K99 AWARDEES, AS

7789
04:45:52,254 --> 04:45:57,059
WELL AS NCI, R01 ITIs WHO

7790
04:45:57,059 --> 04:45:59,862
NEVER APPLIED FOR A K99 TO GET A

7791
04:45:59,862 --> 04:46:02,231
BETTER UNDERSTANDING ABOUT WHAT

7792
04:46:02,231 --> 04:46:03,332
IS WORKING WELL WITH THIS

7793
04:46:03,332 --> 04:46:09,705
MECHANISM AND IF THERE ARE ANY

7794
04:46:09,705 --> 04:46:11,707
PROBLEMS, ANY ISSUES AND THE

7795
04:46:11,707 --> 04:46:13,409
OVERWHELMING FEEDBACK WE

7796
04:46:13,409 --> 04:46:15,277
RECEIVED FOR THE K99 AWARDS FOR

7797
04:46:15,277 --> 04:46:19,581
THIS MECHANISM THAT'S THE K99

7798
04:46:19,581 --> 04:46:22,418
R00 WAS TRIEWMENTAL IN THEIR

7799
04:46:22,418 --> 04:46:23,986
TRANSITION TO INDEPENDENT AND

7800
04:46:23,986 --> 04:46:29,425
HELP THEM TO TEAB A PRODUCTIVE

7801
04:46:29,425 --> 04:46:30,025
INDEPENDENT RESEARCH PROGRAM.

7802
04:46:30,025 --> 04:46:33,362
AND THEY TOLD US THAT THE K99

7803
04:46:33,362 --> 04:46:35,898
AWARD WAS ESSENTIALLY A GOLDEN

7804
04:46:35,898 --> 04:46:39,201
TICKET TO BE INVITED FOR TENURED

7805
04:46:39,201 --> 04:46:41,470
TRACK INTERVIEW, AT AN

7806
04:46:41,470 --> 04:46:43,739
INSTITUTION OF THEIR CHOICE AND

7807
04:46:43,739 --> 04:46:46,975
OUR DATA SUPPORTS US, WE CONTROL

7808
04:46:46,975 --> 04:46:50,045
THE K99 AWARDEES HAVE HIGHER

7809
04:46:50,045 --> 04:46:52,581
MOBILITY COMPARED TO OUR CONTROL

7810
04:46:52,581 --> 04:46:54,249
GROUPS.

7811
04:46:54,249 --> 04:46:55,884
HOWEVER THERE WAS 1 MAJOR PAIN

7812
04:46:55,884 --> 04:46:59,254
POINT BUT YOU HEARD FROM

7813
04:46:59,254 --> 04:47:03,358
APPLICANTS AS WELL AS ESAIs,

7814
04:47:03,358 --> 04:47:13,902
AND THIS WAS UNIQUE REQUIREMENT

7815
04:47:44,433 --> 04:47:47,936
OF THE K99--IT'S A EFFORT ON

7816
04:47:47,936 --> 04:47:48,470
HIGH IMPACT PUBLICATIONS.

7817
04:47:48,470 --> 04:47:50,339
BECAUSE THEY REQUIRE A LONG

7818
04:47:50,339 --> 04:47:51,106
TIME.

7819
04:47:51,106 --> 04:47:54,042
AND IT WOULD PENNALLIZE

7820
04:47:54,042 --> 04:47:56,011
EVERYBODY WHO IS SOMEWHAT

7821
04:47:56,011 --> 04:47:58,914
UNCONVENTIONAL PATHWAY IN THEIR

7822
04:47:58,914 --> 04:47:59,548
CAREER DEVELOPMENT.

7823
04:47:59,548 --> 04:48:01,817
THIS INCHEWEDS POST DOCS WHO

7824
04:48:01,817 --> 04:48:04,887
CHANGE THEIR RESEARCH FIELDS,

7825
04:48:04,887 --> 04:48:10,459
CHANGE LABS, YOU HAD ANY ISSUES,

7826
04:48:10,459 --> 04:48:11,960
[INDISCERNIBLE] AND SO ON, WHAT

7827
04:48:11,960 --> 04:48:13,495
WE ARE NOW PROPOSE SUGGEST

7828
04:48:13,495 --> 04:48:16,365
REALLY ONLY A MINOR CHANGE TO

7829
04:48:16,365 --> 04:48:18,534
THE K99 PROGRAM.

7830
04:48:18,534 --> 04:48:23,939
BE PROPOSED TO EXPAND THE

7831
04:48:23,939 --> 04:48:25,807
ELIGIBILITY FROM 4 YEARS TO 6

7832
04:48:25,807 --> 04:48:29,845
YEARS OF POST DOC EXPERIENCE.

7833
04:48:29,845 --> 04:48:31,280
NOW THIS CHANGE WILL REQUIRE

7834
04:48:31,280 --> 04:48:35,517
THAT NCI HAS ISSUING OUR OWN K99

7835
04:48:35,517 --> 04:48:37,986
R00 P A R.

7836
04:48:37,986 --> 04:48:39,955
WE EXPECT THAT THIS CHANGE WILL

7837
04:48:39,955 --> 04:48:42,491
LEAD TO AN INCREASE IN THE

7838
04:48:42,491 --> 04:48:44,259
APPLICATION NUMBERS FROM

7839
04:48:44,259 --> 04:48:47,629
CURRENTLY 200 APPLICATIONS PER

7840
04:48:47,629 --> 04:48:48,363
YEAR, 2 TO 300.

7841
04:48:48,363 --> 04:48:52,301
AND THEN OF COURSE, OUR BUDGET

7842
04:48:52,301 --> 04:48:54,970
FOR THE K99 WILL INCREASE FROM

7843
04:48:54,970 --> 04:48:57,406
CURRENTLY 6 MILLION TO AROUND

7844
04:48:57,406 --> 04:48:58,040
$10 MILLION.

7845
04:48:58,040 --> 04:49:01,243
NOW IF THE IMPLEMENTS CHANGE OUR

7846
04:49:01,243 --> 04:49:05,447
PLAN IS TO SUN SET THE K22 P A

7847
04:49:05,447 --> 04:49:07,316
R, BECAUSE THIS MECHANISM WILL

7848
04:49:07,316 --> 04:49:10,719
BE NO LONGER NEEDED.

7849
04:49:10,719 --> 04:49:13,455
SEE K22 P A R IS A CAREER

7850
04:49:13,455 --> 04:49:14,990
DEVELOPMENT AWARD THAT ALLOWS UP

7851
04:49:14,990 --> 04:49:19,061
TO 8 YEARS OF POST DOC

7852
04:49:19,061 --> 04:49:21,563
EXPERIENCE AND IS OVERALL THE

7853
04:49:21,563 --> 04:49:26,535
EQUIVALENT OF THE R00 PHASE FROM

7854
04:49:26,535 --> 04:49:27,769
THE K99 R00.

7855
04:49:27,769 --> 04:49:31,273
THIS MEANS THE K22 ONLY SUPPORTS

7856
04:49:31,273 --> 04:49:33,942
POST DOCS, AFTER THEY HAVE

7857
04:49:33,942 --> 04:49:36,578
TRANSITIONED TO THEIR RESEARCH

7858
04:49:36,578 --> 04:49:36,878
INDEPENDENT.

7859
04:49:36,878 --> 04:49:40,415
WE ARE NOT REQUESTING ADDITIONAL

7860
04:49:40,415 --> 04:49:45,187
FUNDING FOR THE NCI K99/R00 P A

7861
04:49:45,187 --> 04:49:47,689
R BECAUSE THE EXPECTED COST OF

7862
04:49:47,689 --> 04:49:49,758
THIS PROGRAM WOULD BE LESS THAN

7863
04:49:49,758 --> 04:49:54,963
THE COMBINED COST OF THE CURRENT

7864
04:49:54,963 --> 04:49:57,833
[INDISCERNIBLE] K99 AND THE K22

7865
04:49:57,833 --> 04:49:58,100
COMBINED.

7866
04:49:58,100 --> 04:50:01,903
HOWEVER, THE COST FOR THE R00

7867
04:50:01,903 --> 04:50:06,642
PHASE WILL INCREASE BY

7868
04:50:06,642 --> 04:50:09,811
$6 MILLION, TO ABOUT

7869
04:50:09,811 --> 04:50:10,178
$25.5 MILLION.

7870
04:50:10,178 --> 04:50:12,681
WITH OUR OUR REVIEWERS AND OUR

7871
04:50:12,681 --> 04:50:15,317
SUBMITEE, WE HAVE DISCUSSED

7872
04:50:15,317 --> 04:50:19,287
POTENTIAL DOWN SIDES AND

7873
04:50:19,287 --> 04:50:22,691
UNINTENDED CONSEQUENCES AND 1

7874
04:50:22,691 --> 04:50:24,226
CONCERNED REVIEWERS RAISED WAS

7875
04:50:24,226 --> 04:50:25,427
THAT CHANGE, THIS CHANGE FROM 4

7876
04:50:25,427 --> 04:50:32,367
YEARS TO 6 YEARS OF POST DOC

7877
04:50:32,367 --> 04:50:34,069
EXPERIENCE PUT [INDISCERNIBLE]

7878
04:50:34,069 --> 04:50:36,805
REVIEW BIAS FOR MORE EXPERIENCE

7879
04:50:36,805 --> 04:50:38,740
APPLICANTS, APPLICANTS WHO MAYBE

7880
04:50:38,740 --> 04:50:42,778
HAVE MORE PUBLICATIONS OR

7881
04:50:42,778 --> 04:50:43,378
STRONGER TRAINING EXPERIENCE.

7882
04:50:43,378 --> 04:50:46,014
AND WE PLAN TO ADDRESS THIS BY

7883
04:50:46,014 --> 04:50:48,884
MODIFYING THE REVIEW CRITERIA

7884
04:50:48,884 --> 04:50:52,487
FOR THE NCI K99 RWHERE ARE 0

7885
04:50:52,487 --> 04:50:53,388
[INDISCERNIBLE] ANNOUNCEMENT.

7886
04:50:53,388 --> 04:50:56,558
AND WE WILL REQUEST THAT

7887
04:50:56,558 --> 04:50:58,193
REVIEWERS WHO WANT TO WAIT

7888
04:50:58,193 --> 04:50:59,895
APPLICANTS IN THE CONTEXT OF

7889
04:50:59,895 --> 04:51:02,297
THERE ARE CAREER STAGE AND WE

7890
04:51:02,297 --> 04:51:04,066
WILL REQUEST THAT REVIEWERS

7891
04:51:04,066 --> 04:51:09,271
FOCUS ON THE READINESS OF

7892
04:51:09,271 --> 04:51:11,173
APPLICANTS FOR THEIR TRANSITION

7893
04:51:11,173 --> 04:51:13,241
TO INDEPENDENCE, INDEPENDENT OF

7894
04:51:13,241 --> 04:51:16,178
YEARS OF POST DOCTORAL TRAINING

7895
04:51:16,178 --> 04:51:16,445
RECEIVED.

7896
04:51:16,445 --> 04:51:18,914
THEN THERE WAS A CONCERN THAT AN

7897
04:51:18,914 --> 04:51:21,717
TENSION TO 6 YEARS WE MIGHT NOT

7898
04:51:21,717 --> 04:51:22,984
BE AS SUFFICIENT.

7899
04:51:22,984 --> 04:51:25,153
THAT IT MIGHT BE BENEFICIAL TO

7900
04:51:25,153 --> 04:51:28,890
EXTEND MAYBE TO 10 YEARS, BUT TO

7901
04:51:28,890 --> 04:51:31,526
JUST SIMPLY REQUIRE THE K99

7902
04:51:31,526 --> 04:51:36,431
APPLICANTS MUST BE IN A MENTORED

7903
04:51:36,431 --> 04:51:36,998
NONINDEPENDENT POSITION.

7904
04:51:36,998 --> 04:51:39,501
AND I THINK THIS A VERY

7905
04:51:39,501 --> 04:51:40,569
INTERESTING SORT, BUT WE FEEL IT

7906
04:51:40,569 --> 04:51:45,307
MIGHT BE BEST TO REALLY HAVE A

7907
04:51:45,307 --> 04:51:48,343
MORE [INDISCERNIBLE] THOUGHT TO

7908
04:51:48,343 --> 04:51:49,978
GO TO INCREASE ABILITY FROM 4

7909
04:51:49,978 --> 04:51:54,182
YEARS TO 6 YEARS AND MONEY TO

7910
04:51:54,182 --> 04:51:56,017
OUR APPLICANT POOL, MONITOR OUR

7911
04:51:56,017 --> 04:51:57,886
DEEP POOL AND THEN PROPOSE

7912
04:51:57,886 --> 04:52:01,389
FURTHER EXTENSIONS IN THE FUTURE

7913
04:52:01,389 --> 04:52:02,224
IF NECESSARY EMPLOY AND OF

7914
04:52:02,224 --> 04:52:09,564
COURSE WE WILL CONTINUE TO BE

7915
04:52:09,564 --> 04:52:11,032
FLEXIBLE BY PROVIDING EXIBILITY

7916
04:52:11,032 --> 04:52:12,267
FOR CRITICAL LIFE EVENTS AND

7917
04:52:12,267 --> 04:52:14,069
EXTENSIONS AND SO ON.

7918
04:52:14,069 --> 04:52:15,570
AND THEN THERE WAS CONCERN THAT

7919
04:52:15,570 --> 04:52:19,975
WE SHOULD BE VERY SPECIFIC IN

7920
04:52:19,975 --> 04:52:23,145
THE PROGRAM ANNOUNCEMENT ABOUT

7921
04:52:23,145 --> 04:52:25,413
ACCEPTABLE POSITION TITLES FROM

7922
04:52:25,413 --> 04:52:28,617
OUR POST DOCTORAL APPLICANTS, TO

7923
04:52:28,617 --> 04:52:30,952
COMA TITLES ARE ELIGIBLE, AND

7924
04:52:30,952 --> 04:52:33,121
WHICH ARE NOT ELIGIBLE AND OUR

7925
04:52:33,121 --> 04:52:36,558
PLAN WOULD BE TO ALLOW

7926
04:52:36,558 --> 04:52:39,594
APPLICATIONS FROM RESEARCH

7927
04:52:39,594 --> 04:52:41,663
ASSOCIATES, STAFF SCIENTISTS,

7928
04:52:41,663 --> 04:52:43,965
AND INSTRUCTORS, AS LONG AS THEY

7929
04:52:43,965 --> 04:52:50,639
CAN JUSTIFY THAT THEY ARE IN THE

7930
04:52:50,639 --> 04:52:51,573
MENTORS NONINDEPENDENT POSITION.

7931
04:52:51,573 --> 04:52:53,275
NOKAY, THANK YOU VERY MUCH AND I

7932
04:52:53,275 --> 04:52:56,378
WOULD LIKE TO--I WILL BE WELCOME

7933
04:52:56,378 --> 04:52:57,279
TO ANSWER QUESTIONS.

7934
04:52:57,279 --> 04:52:58,146
>> WELL, I'M ANYTHING TO
BE

7935
04:52:58,146 --> 04:53:00,115
INTERESTED IN THE COMMITTEE

7936
04:53:00,115 --> 04:53:02,517
REVIEWED HERE MYSELF.

7937
04:53:02,517 --> 04:53:02,884
NREADY?

7938
04:53:02,884 --> 04:53:03,151
>> YES.

7939
04:53:03,151 --> 04:53:05,754
>> YOU WANT TO ASK FIRST
OR GO

7940
04:53:05,754 --> 04:53:08,356
FIRST? 

7941
04:53:08,356 --> 04:53:09,191
>> WE LOVE THIS.

7942
04:53:09,191 --> 04:53:10,659
AND THE REASON WE LOVE THIS IS

7943
04:53:10,659 --> 04:53:12,294
BECAUSE THE K99 IS 1 OF THE VERY

7944
04:53:12,294 --> 04:53:15,630
FEW MECH NICHES THAT WILL

7945
04:53:15,630 --> 04:53:16,665
SUPPORT INDIVIDUAL WHO IS ARE

7946
04:53:16,665 --> 04:53:19,334
NOT U.S. CITIZEN AND MANY OF OUR

7947
04:53:19,334 --> 04:53:22,838
TRAINEES ARE NOT ELIGIBLE FOR

7948
04:53:22,838 --> 04:53:25,073
K08S FOR EXAMPLE OR K22S BECAUSE

7949
04:53:25,073 --> 04:53:26,441
OF THAT REQUIREMENT WHICH I

7950
04:53:26,441 --> 04:53:28,610
THINK MOST OF US WOULD AGREE HAS

7951
04:53:28,610 --> 04:53:29,811
AN EXTRAORDINARY HA MOUNT OF

7952
04:53:29,811 --> 04:53:31,713
DIAS AND THERE'S NOT A LOT OF

7953
04:53:31,713 --> 04:53:32,614
RATIONAL IN TODAY'S

7954
04:53:32,614 --> 04:53:34,683
MULTICULTURAL U.S. TO NOT ALLOW

7955
04:53:34,683 --> 04:53:37,018
THESE PEOPLE TO APPLY, IT IS

7956
04:53:37,018 --> 04:53:38,753
ABSOLUTELY THE GOLDEN TICKET,

7957
04:53:38,753 --> 04:53:42,457
THOSE OF US WHO HAVE MENTORS K99

7958
04:53:42,457 --> 04:53:43,725
AWARDEES, THOSE OF US WHO HAVE

7959
04:53:43,725 --> 04:53:46,795
HIRED PEOPLE WITH R00S

7960
04:53:46,795 --> 04:53:48,496
UNDERSTAND THAT THIS IS AN

7961
04:53:48,496 --> 04:53:50,732
EXTRAORDINARY MECHANISM AND IT

7962
04:53:50,732 --> 04:53:51,700
NEEDS TO BE PRESERVED AND

7963
04:53:51,700 --> 04:53:57,105
THERE'S NO DOUBT THAT THE 4 YEAR

7964
04:53:57,105 --> 04:54:01,843
TIME SPAN REQUIRES AN ARTIFICIAL

7965
04:54:01,843 --> 04:54:03,678
ADHERENCE TO THE IDEA THAT YOU

7966
04:54:03,678 --> 04:54:05,947
HAVE TO SUBMIT BY THIS DATE, AND

7967
04:54:05,947 --> 04:54:08,083
SO HAVE YOU 2 SHOTS ON GOAL.

7968
04:54:08,083 --> 04:54:09,784
AND THAT'S A TERRIBLE IDEA

7969
04:54:09,784 --> 04:54:10,852
BECAUSE GRANTS SHOULD BE

7970
04:54:10,852 --> 04:54:12,721
SUBMITTED WHEN THEY'RE READY AND

7971
04:54:12,721 --> 04:54:14,489
SO WE WERE REALLY EXCITED ABOUT

7972
04:54:14,489 --> 04:54:15,957
THIS NEW FLEXIBILITY, WE THINK

7973
04:54:15,957 --> 04:54:19,027
IT WILL OPEN UP THE APPLICATION

7974
04:54:19,027 --> 04:54:25,066
POOL TO A MORE DIVERSE POOL OF

7975
04:54:25,066 --> 04:54:26,001
TALENTED INDIVIDUALS AND REALLY

7976
04:54:26,001 --> 04:54:28,403
FULFILL THE PROMISE OF THIS

7977
04:54:28,403 --> 04:54:29,304
AWARD.

7978
04:54:29,304 --> 04:54:31,773
WE DID INTRODUCE THIS WHACKY

7979
04:54:31,773 --> 04:54:33,642
IDEA OF ELIMINATING ANY KIND OF

7980
04:54:33,642 --> 04:54:34,676
A YEAR LIMIT.

7981
04:54:34,676 --> 04:54:36,778
IT'S REALLY THE SPIRIT OF TAKING

7982
04:54:36,778 --> 04:54:38,313
SOMEONE WHO'S IN A

7983
04:54:38,313 --> 04:54:39,347
MENTOREDDUATION AND PROVIDING

7984
04:54:39,347 --> 04:54:40,415
THEM A PATHWAY TO INDEPENDENT

7985
04:54:40,415 --> 04:54:42,384
BUT WHAT YOU DIDN'T MENTION

7986
04:54:42,384 --> 04:54:43,184
DR. SCHMITT THAT WE REALLY

7987
04:54:43,184 --> 04:54:46,755
APPRECIATED IS THAT THIS NEEDS

7988
04:54:46,755 --> 04:54:48,156
TO BE CULTURALLY HARMONIZED

7989
04:54:48,156 --> 04:54:51,927
WITHIN THE NIH AND THAT ALREADY

7990
04:54:51,927 --> 04:54:53,628
NCI'S DOING SOMETHING RADICAL BY

7991
04:54:53,628 --> 04:54:56,765
GOING FROM 4 YEARS TO 6 YEARS SO

7992
04:54:56,765 --> 04:54:59,935
WE'RE VERY RESPECTFUL OF DOING

7993
04:54:59,935 --> 04:55:00,902
THIS INCREMENTALLY BUT WE REALLY

7994
04:55:00,902 --> 04:55:02,904
LOVE THE IDEA AND MAYBE WHAT ID

7995
04:55:02,904 --> 04:55:05,440
JUST SAY SLIGHTLY DIFFERENTLY

7996
04:55:05,440 --> 04:55:06,408
DR. SCHMITT IS WHAT WE WANT TO

7997
04:55:06,408 --> 04:55:07,943
EMPHASIZE IS THAT SO MANY OF OUR

7998
04:55:07,943 --> 04:55:09,344
INSTITUTIONS AND YOU KNOW TRAIR

7999
04:55:09,344 --> 04:55:10,779
AND I WORK AT THE UNIVERSITY OF

8000
04:55:10,779 --> 04:55:12,180
CALIFORNIA, YOU CAN'T BE A POST

8001
04:55:12,180 --> 04:55:13,581
DOC FOR MORE THAN 5 YEARS AND I

8002
04:55:13,581 --> 04:55:16,017
THINK THIS IS TRUE IN MANY, MANY

8003
04:55:16,017 --> 04:55:19,054
PLACES, SO WHY NOT ELIMINATE THE

8004
04:55:19,054 --> 04:55:20,255
YOB CORPS TITLE IN SO RATHER

8005
04:55:20,255 --> 04:55:21,990
THAN CALL IN A POST DOCTORAL

8006
04:55:21,990 --> 04:55:23,291
SCHOLAR ARK WARD OR ANYTHING

8007
04:55:23,291 --> 04:55:25,026
THAT IT IMPLIES A SPECIFIC

8008
04:55:25,026 --> 04:55:27,595
TITLE, IT'S REALLY A MENTORED

8009
04:55:27,595 --> 04:55:31,199
AWARD FOR SOMEONE HAS A PATHWAY

8010
04:55:31,199 --> 04:55:31,766
TO INDEPENDENT.

8011
04:55:31,766 --> 04:55:34,069
BUT WE WERE VERY ENTHUSIASTIC

8012
04:55:34,069 --> 04:55:36,471
AND APPRECIATED THE CONVERSATION

8013
04:55:36,471 --> 04:55:37,739
WITH DR. VOGLER AND SCHMITT AND

8014
04:55:37,739 --> 04:55:39,040
THANK YOU FOR TAKING OUR

8015
04:55:39,040 --> 04:55:39,941
COMMENTS INTO CONSIDERATION AND

8016
04:55:39,941 --> 04:55:45,046
I WILL TURN IT OVER TO TREY AND

8017
04:55:45,046 --> 04:55:45,413
SYLVIA.

8018
04:55:45,413 --> 04:55:46,581
>> I'LL KEEP MY COMMENTS
BRIEF

8019
04:55:46,581 --> 04:55:47,882
BECAUSE I THOUGHT MICHAEL DID A

8020
04:55:47,882 --> 04:55:49,417
FANTASTIC YOB CORPS IN

8021
04:55:49,417 --> 04:55:51,286
PRESENTING THE CONCEPT AND JENNY

8022
04:55:51,286 --> 04:55:53,321
DID A FANTASTIC JOB OF

8023
04:55:53,321 --> 04:55:54,522
SUMMARIZING THE DISCUSSIONS WE

8024
04:55:54,522 --> 04:55:55,857
HAD ON SUBEXITEE.

8025
04:55:55,857 --> 04:56:00,362
MY INPUT ALREADY WAS MADE THERE,

8026
04:56:00,362 --> 04:56:03,331
I'LL JUST SIMPLY REPEAT IN

8027
04:56:03,331 --> 04:56:05,166
60-SECURITIZATION.S OR LESS THE

8028
04:56:05,166 --> 04:56:06,568
HIGHLIGHTS, ALL THINK AFRONS OF

8029
04:56:06,568 --> 04:56:08,870
US ON THE SUBCOMMITTEE HAVE BEEN

8030
04:56:08,870 --> 04:56:10,138
TOUCHED, PEOPLE IN OUR LAB

8031
04:56:10,138 --> 04:56:12,340
TOUCHED IN A POSITIVE WAY BY

8032
04:56:12,340 --> 04:56:13,675
K99S AND SEEING THE MAGIC THAT

8033
04:56:13,675 --> 04:56:15,777
HAPPENS TO THEIR CAREERS, IT'S

8034
04:56:15,777 --> 04:56:18,313
JUST AN AND AGAIN,LET FACT THAT

8035
04:56:18,313 --> 04:56:21,649
IT'S OPEN TO NONU.S. CITIZEN IS

8036
04:56:21,649 --> 04:56:22,584
PHENOMENAL AND THE EXCEPTION AS

8037
04:56:22,584 --> 04:56:27,489
FAR AS I KNOW AMONG THE NIH,

8038
04:56:27,489 --> 04:56:27,689
K99S.

8039
04:56:27,689 --> 04:56:29,357
IN TERMS OF THIS VERY

8040
04:56:29,357 --> 04:56:30,492
INTERESTING SUGGESTION TO JUST

8041
04:56:30,492 --> 04:56:32,127
DROP THE REQUIREMENT, WELL,

8042
04:56:32,127 --> 04:56:33,528
YEAH, SO, IF YOU'RE GOING TO

8043
04:56:33,528 --> 04:56:35,263
DROP THE REQUIREMENT OR EXTEND

8044
04:56:35,263 --> 04:56:36,097
THE REQUIREMENT, YOU WANT TO

8045
04:56:36,097 --> 04:56:42,437
MAKE SURE YOU DO NOT KEEP

8046
04:56:42,437 --> 04:56:45,740
UNWITTINGLY BIAS THIS TO

8047
04:56:45,740 --> 04:56:47,475
INSTITUTIONS WHO ALLOW 6 YEAR

8048
04:56:47,475 --> 04:56:48,476
POST DOCS BECAUSE MANY DON'T.

8049
04:56:48,476 --> 04:56:50,612
SO YOU HAVE TO DEAL WITH JUST

8050
04:56:50,612 --> 04:56:52,781
THE NAMING AND THE MESSAGING

8051
04:56:52,781 --> 04:56:54,315
THERE AND JENNY ALREADY CAPTURED

8052
04:56:54,315 --> 04:56:56,317
THAT AND IN TERPS SHOULD WE DROP

8053
04:56:56,317 --> 04:56:58,920
IT, GO TO 6 YEARS, 4 YEESHS, 10

8054
04:56:58,920 --> 04:57:01,890
YEARS, THE COMMITTEE IS EQUALLY

8055
04:57:01,890 --> 04:57:04,192
CONFUSED IN A WAY, WE AGREE IT'S

8056
04:57:04,192 --> 04:57:05,760
A COMPLEX ISSUE AND SO REALLY

8057
04:57:05,760 --> 04:57:07,262
THE PROPOSAL TO DROP IF I COULD

8058
04:57:07,262 --> 04:57:10,365
ADD ANYTHING WAS SIMPLY

8059
04:57:10,365 --> 04:57:11,166
[INDISCERNIBLE], WE DON'T KNOW

8060
04:57:11,166 --> 04:57:13,735
WHAT THE BEST THING TO DO IS AND

8061
04:57:13,735 --> 04:57:14,269
THEREFORE DO LESS.

8062
04:57:14,269 --> 04:57:17,272
ANYTIME YOU DRAW A LINE IN THE

8063
04:57:17,272 --> 04:57:18,239
SAND, YOU'RE PERTURBING A SYSTEM

8064
04:57:18,239 --> 04:57:20,508
IN A COMPLEX WAY AND IT'S HARD

8065
04:57:20,508 --> 04:57:27,415
TO ANTICIPATE AND I THINK

8066
04:57:27,415 --> 04:57:28,817
MICHAEL'S PUSH BACK WAS WE WILL

8067
04:57:28,817 --> 04:57:29,784
STUDY THIS BUT WE THEED TO

8068
04:57:29,784 --> 04:57:31,586
UNDERSTAND THE THRESHOLD AND

8069
04:57:31,586 --> 04:57:36,391
IT'S COMPLICATED.

8070
04:57:36,391 --> 04:57:36,858
>> SYLVIA?

8071
04:57:36,858 --> 04:57:38,293
>> YEAH, I GREAN, I THINK
THE

8072
04:57:38,293 --> 04:57:39,894
DISCUSSION VS BEEN REALLY

8073
04:57:39,894 --> 04:57:40,261
FRUITFUL.

8074
04:57:40,261 --> 04:57:41,629
I THINK I WILL TOUCH ON SOME

8075
04:57:41,629 --> 04:57:42,664
POINTS THAT WERE ALREADY MADE

8076
04:57:42,664 --> 04:57:47,268
BUT MAYBE A LITTLE BIT MORE TO

8077
04:57:47,268 --> 04:57:47,802
THE DISCUSSION.

8078
04:57:47,802 --> 04:57:49,404
SO I DON'T THINK WHAT WAS

8079
04:57:49,404 --> 04:57:51,706
MENTION INDEED THE PRESENTATION

8080
04:57:51,706 --> 04:57:53,441
AND THE SUBCOMMITTEE IS ORIGE

8081
04:57:53,441 --> 04:57:54,742
NAWILLLY THIS PROGRAM WAS AT 5

8082
04:57:54,742 --> 04:57:56,411
YEARS AND THEN IT MOVED TO 4

8083
04:57:56,411 --> 04:57:58,446
YEARS SO ALIGNED WITH THE NIH

8084
04:57:58,446 --> 04:57:59,614
GUIDELINES, THE WHYED IS TO NOW

8085
04:57:59,614 --> 04:58:02,984
MOVE OUT OF THE NIH UMBRELLA AND

8086
04:58:02,984 --> 04:58:04,886
BRING IT TO THE NCI AND

8087
04:58:04,886 --> 04:58:06,020
INCREASING NOT TO 5 YEARS BUT TO

8088
04:58:06,020 --> 04:58:08,523
GO TO 6 YEARS, SO WE WERE KIND

8089
04:58:08,523 --> 04:58:10,925
OF ASKING, WHY NOT GO BACK TO 5

8090
04:58:10,925 --> 04:58:17,065
YEARS, WHY 6 YEARS, WHY ANY

8091
04:58:17,065 --> 04:58:19,501
YEARS, AND SO I BEING THE INTEND

8092
04:58:19,501 --> 04:58:21,503
IS THE RIGHT INTENT WE'RE ALL

8093
04:58:21,503 --> 04:58:23,204
READY TO DISCUSS.

8094
04:58:23,204 --> 04:58:24,339
IT IS A IMPORTANT ISSUE.

8095
04:58:24,339 --> 04:58:26,774
ONE OF THE DISCUSSION POINT WAS

8096
04:58:26,774 --> 04:58:27,709
THAT THERE'S DIFFICULT MOUSE

8097
04:58:27,709 --> 04:58:28,776
MODEL RESEARCH FOR EXAMPLE THAT

8098
04:58:28,776 --> 04:58:32,647
JUST TAKES A REALLY, REALLY LONG

8099
04:58:32,647 --> 04:58:33,848
TIME AND SOME PEOPLE DON'T GET

8100
04:58:33,848 --> 04:58:36,050
THAT BIG PAPER OUT FOR LIKE 5 OR

8101
04:58:36,050 --> 04:58:38,153
6 YEARS, AND SELL, AND IN SOME

8102
04:58:38,153 --> 04:58:40,488
WAY, YOU KNOW I WAS MAKING THE

8103
04:58:40,488 --> 04:58:42,390
POINT, DO WE REALLY WANT TO

8104
04:58:42,390 --> 04:58:44,692
ENCOURAGE, LIKE, YOU KNOW A 1

8105
04:58:44,692 --> 04:58:46,194
PAPER PERSON, LIKE WORKING FOR 6

8106
04:58:46,194 --> 04:58:47,729
YEARS ON 1 CELL PAPER, IS THAT

8107
04:58:47,729 --> 04:58:51,599
WHAT WE REALLY WANT TO

8108
04:58:51,599 --> 04:58:51,866
ENCOURAGE.

8109
04:58:51,866 --> 04:58:53,968
BUT I THINK THAT GETS INTO

8110
04:58:53,968 --> 04:58:54,903
MINUTIA, I THINK THE FLEXIBILITY

8111
04:58:54,903 --> 04:58:58,540
IS BETTER AND AS WAS SHARED BY

8112
04:58:58,540 --> 04:59:03,444
MY COLLEAGUES ON THE

8113
04:59:03,444 --> 04:59:05,346
SUBCOMMITTEE AND IN THAT MIND

8114
04:59:05,346 --> 04:59:06,414
SET OF FLEXIBILITY, THIS ACTION

8115
04:59:06,414 --> 04:59:08,750
IS REALLY TIED TO ULTIMATELY SUN

8116
04:59:08,750 --> 04:59:10,818
SETTING THE K22, AND THE TITLE

8117
04:59:10,818 --> 04:59:14,923
OF THE K22 IS A CAREER

8118
04:59:14,923 --> 04:59:15,323
TRANSITION AWARD.

8119
04:59:15,323 --> 04:59:16,558
SO IT HAS A DIFFERENT KIND OF

8120
04:59:16,558 --> 04:59:19,394
FLAVOR TO IT AND WE DON'T WANT

8121
04:59:19,394 --> 04:59:21,296
TO LOSE THAT THERE'S A POOL OF

8122
04:59:21,296 --> 04:59:22,463
PEOPLE THAT WE WANT TO

8123
04:59:22,463 --> 04:59:23,998
NECESSARILY BRING BACK INTO

8124
04:59:23,998 --> 04:59:26,501
ACADEMIA, WHILE, YOU KNOW

8125
04:59:26,501 --> 04:59:27,902
THEY'RE POST DOCTORATES NOT

8126
04:59:27,902 --> 04:59:29,204
DOING POST DOCTORAL RESEARCH IN

8127
04:59:29,204 --> 04:59:30,505
THE TECHNICAL SENSE OF THE WORD,

8128
04:59:30,505 --> 04:59:32,507
THE WAY YOU APPLY AT AND YOU WE

8129
04:59:32,507 --> 04:59:33,808
ALSO HAVE THE 5 YEAR RULE, SOME

8130
04:59:33,808 --> 04:59:35,410
OF THESE FOLKS AFTER 5 YEARS

8131
04:59:35,410 --> 04:59:39,981
MOVE INTO INTRUCTOR POGS OR

8132
04:59:39,981 --> 04:59:40,682
RESEARCH SCIENTISTS POSITIONS

8133
04:59:40,682 --> 04:59:42,750
AND AS LONG AS THEY'RE A MENTOR

8134
04:59:42,750 --> 04:59:45,720
THAT WOULD BE ELIGIBLE AND THAT

8135
04:59:45,720 --> 04:59:48,056
GOT TO A THIRD DISCUSSION SLIDES

8136
04:59:48,056 --> 04:59:48,723
AND SUBCOMMITTEE DISCUSSION AND

8137
04:59:48,723 --> 04:59:52,427
SO I JUST WANT TO REEMPHASIZE

8138
04:59:52,427 --> 04:59:53,928
THAT POINT BECAUSE THERE IS A

8139
04:59:53,928 --> 04:59:55,296
POST DOCTORAL TRAINING CONCEPT

8140
04:59:55,296 --> 04:59:56,631
BUT PEOPLE DO POST DOCTORAL

8141
04:59:56,631 --> 04:59:57,966
RESEARCH IN OTHER ENVIRONMENTS

8142
04:59:57,966 --> 04:59:59,567
AND INDUSTRY AND WANT TO

8143
04:59:59,567 --> 05:00:00,768
TRANSITION BACK INTO ACADEMIA,

8144
05:00:00,768 --> 05:00:06,441
SO AS LONG AS WE CAPTURE THAT

8145
05:00:06,441 --> 05:00:07,375
ELEMENT AND KEEP THAT ELEMENT

8146
05:00:07,375 --> 05:00:09,043
WITH THE SUN SETTING OF K22,

8147
05:00:09,043 --> 05:00:15,583
TELL BE A VERY SUCCESSFUL

8148
05:00:15,583 --> 05:00:16,517
PROGRAM.

8149
05:00:16,517 --> 05:00:18,019
NCHAIR'S PREROGATIVE, I ONLY

8150
05:00:18,019 --> 05:00:19,654
WORRY ABOUT IT FLIES IN THE FACE

8151
05:00:19,654 --> 05:00:21,556
OF WE HAVE, WE ARE PUSHING BACK

8152
05:00:21,556 --> 05:00:26,661
THE TIME FOR FIRST RO-1S SO FAR

8153
05:00:26,661 --> 05:00:27,061
ALREADY.

8154
05:00:27,061 --> 05:00:28,062
IESM WORRIED ABOUT STUDY

8155
05:00:28,062 --> 05:00:29,130
SECTIONS BASICALLY, WE CAN TELL

8156
05:00:29,130 --> 05:00:32,667
THEM WHAT TO DO, QUOTE-UNQUOTE

8157
05:00:32,667 --> 05:00:33,735
BUT NOW 6 YEAR ANYTHING TO BE

8158
05:00:33,735 --> 05:00:35,036
THE NORM FOR THIS SO I THINK

8159
05:00:35,036 --> 05:00:36,437
THERE NEEDS TO BE REAL

8160
05:00:36,437 --> 05:00:37,505
DISCIPLINE FROM THE STUDY

8161
05:00:37,505 --> 05:00:39,507
SECTIONS IF PEOPLE ARE READY, AT

8162
05:00:39,507 --> 05:00:41,676
4 YEARS OR 5 YEARS, THEY SHOULD

8163
05:00:41,676 --> 05:00:48,883
BE ABLE TO GO FORWARD.

8164
05:00:48,883 --> 05:00:51,419
NI AGREE WITH YOU SHELLY AND

8165
05:00:51,419 --> 05:00:52,620
DR. SCHMITT, YOU DID YOURSELF

8166
05:00:52,620 --> 05:00:54,222
CREDIT, THEY ARE STUDYING WHAT

8167
05:00:54,222 --> 05:00:56,424
THEY ARE DOING, IT'S AN

8168
05:00:56,424 --> 05:00:57,258
ITERATIVE PROCESS, AND THIS IS

8169
05:00:57,258 --> 05:01:00,028
JUST MAKING SURE WE DON'T PUSH

8170
05:01:00,028 --> 05:01:02,363
THE FIRST RO-1 DOWN THE LINE BUT

8171
05:01:02,363 --> 05:01:03,364
INCREASING OPPORTUNITIES FOR

8172
05:01:03,364 --> 05:01:04,499
INDIVIDUALS WHO NEED THIS GRANT

8173
05:01:04,499 --> 05:01:08,636
IN ORDER TO SUCCEED.

8174
05:01:08,636 --> 05:01:10,204
>> PROGRAM'S BEEN TERRIBLY

8175
05:01:10,204 --> 05:01:10,505
SUCCESSFUL.

8176
05:01:10,505 --> 05:01:11,339
>> HERE, HERE.

8177
05:01:11,339 --> 05:01:17,045
OH BOY, OKAY.

8178
05:01:17,045 --> 05:01:18,012
>> I'M SORRY.

8179
05:01:18,012 --> 05:01:19,180
NASHLEY GO AHEAD, SO FIRST OF

8180
05:01:19,180 --> 05:01:21,482
ALL I LOVE THIS, I HAVE A

8181
05:01:21,482 --> 05:01:24,319
HUNDRED PERCENT EXCITE BIDE THIS

8182
05:01:24,319 --> 05:01:26,020
AS SOMEONE WHO'S TRAINEES WORK

8183
05:01:26,020 --> 05:01:28,456
ON 18 MONTH OLD MICE IT'S LOVELY

8184
05:01:28,456 --> 05:01:29,791
THEY GET MORE TIME TO GET

8185
05:01:29,791 --> 05:01:30,458
PAPERS.

8186
05:01:30,458 --> 05:01:31,659
I JUST WANTED TO ASK WHETHER

8187
05:01:31,659 --> 05:01:32,960
THERE'S ANY MOVE OR ANY THOUGHT

8188
05:01:32,960 --> 05:01:36,831
ABOUT A MOVE TO SHIFTING K08S TO

8189
05:01:36,831 --> 05:01:41,302
BEING NO LONGER U.S. RESTRICTED?

8190
05:01:41,302 --> 05:01:42,804
BECAUSE LOWER INCOME MINORITY

8191
05:01:42,804 --> 05:01:45,340
COUNTRIES I HAVE POST DOCS FROM

8192
05:01:45,340 --> 05:01:47,942
BRAZIL, AFRICA, THEY HAVE NO

8193
05:01:47,942 --> 05:01:48,676
OPPORTUNITIES FOR K99, THEY

8194
05:01:48,676 --> 05:01:50,945
OFTEN COME IN LATER IN THEIR

8195
05:01:50,945 --> 05:01:52,847
POST DOC, FOR K08, AND THEY

8196
05:01:52,847 --> 05:01:56,751
OFTEN COME IN LATER FOR K99S AND

8197
05:01:56,751 --> 05:01:58,453
MISS THE WINDOW WHICH MAY NO

8198
05:01:58,453 --> 05:02:08,930
LONGER BE AN ISSUE BUT TILL.

8199
05:02:12,633 --> 05:02:15,303
>> WE ARE RUNNING OUT OF
TIME,

8200
05:02:15,303 --> 05:02:17,338
LET'S GO QUICKLY.

8201
05:02:17,338 --> 05:02:18,139
>> THE OPPOSITE DIRECTION,
THE

8202
05:02:18,139 --> 05:02:19,540
FITTER THING WE SEE ARE THE

8203
05:02:19,540 --> 05:02:22,577
PEOPLE APPLYING FOR THE K99

8204
05:02:22,577 --> 05:02:24,245
ROOs THE MORE THEY'RE EXPECTED

8205
05:02:24,245 --> 05:02:26,581
TO HAVE, AS YOU MOVE THAT TIME,

8206
05:02:26,581 --> 05:02:27,648
REVIEWER NATURALLY IN THEIR

8207
05:02:27,648 --> 05:02:28,850
HEAD, NO MATTER WHAT YOU SAY TO

8208
05:02:28,850 --> 05:02:30,818
THEM IN A REVIEW COMMITTEE SAY

8209
05:02:30,818 --> 05:02:33,921
THIS PERSON'S BEEN OUT FOR 5

8210
05:02:33,921 --> 05:02:35,056
YEARS, YOU KNOW ESPECIALLY FOR

8211
05:02:35,056 --> 05:02:36,858
US IN POPULATION SCIENTISTS WHO

8212
05:02:36,858 --> 05:02:39,160
ARE DOING THESE K99 ROOs, WHY

8213
05:02:39,160 --> 05:02:41,129
DON'T I HAVE HAVE 25

8214
05:02:41,129 --> 05:02:42,196
PUBLICATIONS INSTEAD OF 17, SO

8215
05:02:42,196 --> 05:02:44,198
YOU HAVE TO BE REALLY CAREFUL

8216
05:02:44,198 --> 05:02:45,566
ABOUT THAT AS PART OF THIS

8217
05:02:45,566 --> 05:02:49,771
BECAUSE THAT COULD HAVE A SUPER

8218
05:02:49,771 --> 05:02:50,438
UNINTENDED QUONSQUENCE WHERE YOU

8219
05:02:50,438 --> 05:02:52,106
MOVE THE TIME BUT YET THE

8220
05:02:52,106 --> 05:02:53,741
PARALSO MOVES IN TERMS OF WHAT'S

8221
05:02:53,741 --> 05:02:56,677
EXPECTED OF THESE INDIVIDUALS.

8222
05:02:56,677 --> 05:02:58,780
AND 1 LAST THING, WE'VE ALREADY

8223
05:02:58,780 --> 05:03:01,082
HAD SUCCESS WHERE WE HAVE PEOPLE

8224
05:03:01,082 --> 05:03:04,085
WHO ARE ON LIKE FOR EXAMPLE OUR

8225
05:03:04,085 --> 05:03:06,187
NCI T32 WHERE WE GIVE THEM

8226
05:03:06,187 --> 05:03:07,655
RESEARCH ASSISTANT PROFESSOR POG

8227
05:03:07,655 --> 05:03:09,690
ANDS NCI HAS GRANTED US YOU ARE

8228
05:03:09,690 --> 05:03:11,426
IN A MENTORED POSITION, YES,

8229
05:03:11,426 --> 05:03:13,261
THESE INDIVIDUALS ARE ALLOWED

8230
05:03:13,261 --> 05:03:15,596
TO,A PLIE AND THEY GIVE THAT

8231
05:03:15,596 --> 05:03:16,397
EXCEPTION OR THAT ALLOWS RIGHT

8232
05:03:16,397 --> 05:03:18,399
NOW WITH THE WAY IT'S CURRENTLY

8233
05:03:18,399 --> 05:03:19,000
WRITTEN.

8234
05:03:19,000 --> 05:03:21,035
SO I WOULDN'T SEE WHY THOSE

8235
05:03:21,035 --> 05:03:22,570
OTHER POSITIONS COULDN'T DO THE

8236
05:03:22,570 --> 05:03:27,408
SAME >>  GRAPT, BE QUICK
NYES.

8237
05:03:27,408 --> 05:03:31,078
>> SO I LIKE THIS VERY
MUCH, MY

8238
05:03:31,078 --> 05:03:32,580
QUESTION IS, SINCE THEY WILL NOW

8239
05:03:32,580 --> 05:03:34,215
BE ARK LOWED 6 YEARS TO DEVELOP

8240
05:03:34,215 --> 05:03:35,650
A FULL PROJECT ARE THEY REQUIRED

8241
05:03:35,650 --> 05:03:38,085
TO SPEND THE 2 YEARS IN MENTORED

8242
05:03:38,085 --> 05:03:44,725
POSITION BEFORE THEY CAN MOVE TO

8243
05:03:44,725 --> 05:03:45,259
THE INDEPENDENT POSITION?

8244
05:03:45,259 --> 05:03:46,360
>> NO THEY ARE NOT.

8245
05:03:46,360 --> 05:03:49,163
AT NCI WE ARE VERY FLEXIBLE, WE

8246
05:03:49,163 --> 05:03:50,765
ALLOW TRANSITIONS IN THE FIRST

8247
05:03:50,765 --> 05:03:55,636
YEAR OF THE K99 PHASE HOWEVER

8248
05:03:55,636 --> 05:03:58,239
THESE REQUIRE APPROVAL DIRECTOR

8249
05:03:58,239 --> 05:04:00,475
OF KRRK CT AND THEY HAVE TO

8250
05:04:00,475 --> 05:04:01,509
ACQUIRE THESE EARLY TRANSITIONS

8251
05:04:01,509 --> 05:04:05,379
ARE SUPPORTED BY A VERY STRONG

8252
05:04:05,379 --> 05:04:10,685
OFFER FOR TENURED TRACK

8253
05:04:10,685 --> 05:04:11,352
POSITION.

8254
05:04:11,352 --> 05:04:14,722
BUT IF OUR K99 AWARDEES HAVE A

8255
05:04:14,722 --> 05:04:15,890
STRONG SPOGZ, WE DON'T

8256
05:04:15,890 --> 05:04:16,624
[INDISCERNIBLE] BACK, WE ALLOW

8257
05:04:16,624 --> 05:04:22,630
THEM TO MOVE ON TO INDEPENDENCE

8258
05:04:22,630 --> 05:04:23,831
AS EARLY AS POSSIBLE AND I WOULD

8259
05:04:23,831 --> 05:04:25,533
REALLY LIKE TO CLEARLY STATE IT

8260
05:04:25,533 --> 05:04:27,502
IS NOT OUR INTENTION TO ECTEND

8261
05:04:27,502 --> 05:04:29,770
THE POST DOC PERIOD BEFORE

8262
05:04:29,770 --> 05:04:31,839
ANYBODY CAN MOVE ON TO

8263
05:04:31,839 --> 05:04:32,173
INDEPENDENCE.

8264
05:04:32,173 --> 05:04:34,475
OUR GOAL IS TO HELP THEM, TO

8265
05:04:34,475 --> 05:04:38,212
MOVE ON TO INDEPENDENCE AS EARLY

8266
05:04:38,212 --> 05:04:39,280
AS POSSIBLE, HOWEVER WE WANT TO

8267
05:04:39,280 --> 05:04:43,150
BE A LITTLE MORE FLEXIBLE BY

8268
05:04:43,150 --> 05:04:43,484
UNDERSTANDING.

8269
05:04:43,484 --> 05:04:47,788
>> WE HAVE TO MOVE ALONG,

8270
05:04:47,788 --> 05:04:49,290
MICHAEL ANYTHING REALLY NEW,

8271
05:04:49,290 --> 05:04:50,224
REALLY NEW.

8272
05:04:50,224 --> 05:05:00,601
YOU WILL BE EVALUATED.

8273
05:05:04,906 --> 05:05:05,540
[INDISCERNIBLE] >>  VERY

8274
05:05:05,540 --> 05:05:06,140
DISCOURAGING FOR OUR JUNIOR

8275
05:05:06,140 --> 05:05:08,543
PEOPLE AND I WOULD RATHER HAVE

8276
05:05:08,543 --> 05:05:09,744
SHORTER YEARS BUT I'M FINE WITH

8277
05:05:09,744 --> 05:05:11,279
6 YEARS BUT I WOULD LIKE TO

8278
05:05:11,279 --> 05:05:13,047
REWARD THE GO GETTERS THAT WILL

8279
05:05:13,047 --> 05:05:14,148
BE IN POPULATION SCIENCE WHO

8280
05:05:14,148 --> 05:05:16,551
NEED ONLY 1 OR 2 YEARS THAT THEY

8281
05:05:16,551 --> 05:05:18,185
DON'T GET THIS ADVANTAGE AND

8282
05:05:18,185 --> 05:05:19,887
LET'S THINK ABOUT THIS PAY LINE

8283
05:05:19,887 --> 05:05:22,857
BECAUSE 15% IS VERY LOW OR

8284
05:05:22,857 --> 05:05:26,160
HAVING PEOPLE MOVE ON.

8285
05:05:26,160 --> 05:05:27,895
AND MY QUICK COMMENT IS BY DOING

8286
05:05:27,895 --> 05:05:29,497
THIS ONLY THROUGH NKRRK I AND

8287
05:05:29,497 --> 05:05:32,466
NOT HAVING OTHER INSTITUTES OR

8288
05:05:32,466 --> 05:05:34,502
SO, GOING IN YOU WILL INCREASE A

8289
05:05:34,502 --> 05:05:35,570
LOT OF APPLICATIONS OF PEOPLE

8290
05:05:35,570 --> 05:05:38,406
THAT MAY BE I'M NOT REALLY

8291
05:05:38,406 --> 05:05:40,041
CANCER RELATED BUT THEY'RE GOING

8292
05:05:40,041 --> 05:05:41,709
TO TAKE THESE, MAYBE IT'S NOT AN

8293
05:05:41,709 --> 05:05:43,411
ISSUE BUT OTHER DISCUSSIONS

8294
05:05:43,411 --> 05:05:48,449
WITHIN NIH TO MAKE THIS PRODUCT.

8295
05:05:48,449 --> 05:05:50,151
NWE WILL HAVE TO HAVE A VOTE.

8296
05:05:50,151 --> 05:05:51,485
IT'S GREAT TO BE HERE TOGETHER

8297
05:05:51,485 --> 05:05:53,054
BECAUSE WE REALLY WANT TO TALK.

8298
05:05:53,054 --> 05:05:56,157
DO WE HAVE A MOTION NI MOTION TO

8299
05:05:56,157 --> 05:05:57,758
APPROVE NSECOND.

8300
05:05:57,758 --> 05:06:08,269
>> OKAY, ARE THERE ANY
NAYS?

8301
05:06:08,703 --> 05:06:08,970
>> DISCUSSION.

8302
05:06:08,970 --> 05:06:11,005
>> JUST THE POINT LOOK AT
THAT

8303
05:06:11,005 --> 05:06:13,074
SLIDE ABOUT THE DISTRIBUTION BY

8304
05:06:13,074 --> 05:06:16,844
RACE, I DON'T AGREE THIS IS

8305
05:06:16,844 --> 05:06:18,579
BALANCED, I WANT TO MAKE THAT

8306
05:06:18,579 --> 05:06:20,014
POINT PERHAPS WE SHOULD LOOK AT

8307
05:06:20,014 --> 05:06:23,918
THAT DATA MORE CLOSELY.

8308
05:06:23,918 --> 05:06:32,360
IT DOESN'T TILLLY MEAN IT'S

8309
05:06:32,360 --> 05:06:32,793
BALANCED.

8310
05:06:32,793 --> 05:06:36,097
>> ANY NAYS, ANY
ABSTENTIONS?

8311
05:06:36,097 --> 05:06:39,634
UNANOG --UNANIMOUS.

8312
05:06:39,634 --> 05:06:42,436
IT'S GREAT TO BE TOGETHER.

8313
05:06:42,436 --> 05:06:45,773
THE NEXT IS TOBACCO CONTROL AND

8314
05:06:45,773 --> 05:06:46,374
CANNABIS CONTROL POLICY, WELL

8315
05:06:46,374 --> 05:06:49,710
THAT WOULD BE OF INTEREST.

8316
05:06:49,710 --> 05:06:53,547
THAT WOULD UNANIMOUS, RESEARCH

8317
05:06:53,547 --> 05:06:55,483
FOR HEALTH EQUITY PRIEL

8318
05:06:55,483 --> 05:07:02,556
DR. ANNETTE KAUFMAN AND OUR

8319
05:07:02,556 --> 05:07:05,726
COMMITTEE IS DOROTHY RAY AND

8320
05:07:05,726 --> 05:07:06,093
KAREN.

8321
05:07:06,093 --> 05:07:07,828
DOES EVERYBODY NEED A SEVENTH

8322
05:07:07,828 --> 05:07:08,929
INNING STRETCH, I FEEL LIKE

8323
05:07:08,929 --> 05:07:09,397
MAYBE WE DO.

8324
05:07:09,397 --> 05:07:11,699
THANK YOU FOR THE OPPORTUNITY TO

8325
05:07:11,699 --> 05:07:15,903
PRESENT THIS CONCEPT ON TOBACCO

8326
05:07:15,903 --> 05:07:17,471
ALCOHOL AND CANNABIS CONTROL

8327
05:07:17,471 --> 05:07:27,915
POLICY FOR RESEARCH HEGHT

8328
05:08:05,986 --> 05:08:06,153
EQUITY.

8329
05:08:06,153 --> 05:08:08,456
ALL RIGHT RNTION SO THE GOAL OF

8330
05:08:08,456 --> 05:08:10,958
THESE PARS ARE TO SUPPORT R21

8331
05:08:10,958 --> 05:08:12,760
AND RESEARCH PROGECS THAT FOCUS

8332
05:08:12,760 --> 05:08:14,528
ON REDUCING DISPARITIES IN

8333
05:08:14,528 --> 05:08:16,197
TOBACCO ALCOHOL AND/OR KAN--KANA

8334
05:08:16,197 --> 05:08:17,498
BUSINESS PROGRAMS EXPOSURE OR

8335
05:08:17,498 --> 05:08:20,167
USE BY EVALUATING NEW OR

8336
05:08:20,167 --> 05:08:20,835
ADAPTIVE POLICIES PERTAINING TO

8337
05:08:20,835 --> 05:08:22,369
TO BACK O ALCOHOL AND/OR

8338
05:08:22,369 --> 05:08:23,871
KAN--KANA BUSINESS PROGRAMS IN

8339
05:08:23,871 --> 05:08:25,639
THE UNITED STATES.

8340
05:08:25,639 --> 05:08:27,408
BROADLY IN PARWILL AIM TO

8341
05:08:27,408 --> 05:08:28,576
ADDRESS THE OVERARCHING

8342
05:08:28,576 --> 05:08:29,844
HYPOTHESIS THAT TABAK O WHOLE

8343
05:08:29,844 --> 05:08:31,479
AND/OR KAN--KANA BUSINESS

8344
05:08:31,479 --> 05:08:32,980
PROGRAMS POLICIES DIFFERENTIALLY

8345
05:08:32,980 --> 05:08:37,752
IMPACT THE EXPOSURE AND/OR USE

8346
05:08:37,752 --> 05:08:41,288
OF SUBSTANCES AMONG DISPARATE

8347
05:08:41,288 --> 05:08:41,889
POPULATIONS.

8348
05:08:41,889 --> 05:08:42,723
AS BACKGROUND TOBACCO ALCOHOL

8349
05:08:42,723 --> 05:08:44,058
AND KAN--KANA BUSINESS PROGRAMS

8350
05:08:44,058 --> 05:08:45,793
ARE THE MOST FREQUENTLY USED

8351
05:08:45,793 --> 05:08:47,561
DRUGS IN THE UNITED STATES

8352
05:08:47,561 --> 05:08:55,169
ACCORD TO THE 2022 NISDA DATA

8353
05:08:55,169 --> 05:09:02,076
PEOPLE AGE  12 ORLEDDER USED THE

8354
05:09:02,076 --> 05:09:03,577
FOLLOWING PRODUCTS IN THE PAST

8355
05:09:03,577 --> 05:09:05,346
MONTH AND WE KNOW THAT

8356
05:09:05,346 --> 05:09:07,314
DISPATHWAY GIVES ARITYS EXIST

8357
05:09:07,314 --> 05:09:08,582
FORRULE 3 SUBSTANCES, 12 MONTH

8358
05:09:08,582 --> 05:09:10,417
AND LIFETIME COMOAL USE DISORDER

8359
05:09:10,417 --> 05:09:12,720
AND HIGHEST WITH THOSE WITH

8360
05:09:12,720 --> 05:09:14,255
LOWER INCOME, CURRENT CIGARETTE

8361
05:09:14,255 --> 05:09:15,656
SMOKING IS ASSOCIATE WIDE LIVING

8362
05:09:15,656 --> 05:09:17,825
IN RURAL AREAS, LOWER EICATION,

8363
05:09:17,825 --> 05:09:20,227
LOWER INCOME AND IDENTIFYING AS

8364
05:09:20,227 --> 05:09:22,029
A SEXUAL MINORITY, AND WEEKLY OR

8365
05:09:22,029 --> 05:09:22,763
MONTHLY KAN--KANA BUSINESS

8366
05:09:22,763 --> 05:09:23,931
PROGRAMS USE AND KAN--KANA

8367
05:09:23,931 --> 05:09:26,333
BUSINESS PROGRAMS DEPENDENCE ARE

8368
05:09:26,333 --> 05:09:27,701
IMRAITER MANNING NATIVE ADULTS

8369
05:09:27,701 --> 05:09:29,904
NATIVE AMERICAN ARK DOUBTS,

8370
05:09:29,904 --> 05:09:33,207
MIXED RACE ADOWLTS COMPARED TO

8371
05:09:33,207 --> 05:09:34,241
WHITE,A DULTS.

8372
05:09:34,241 --> 05:09:36,110
AMONG THOSE THAT USE RESEARCH

8373
05:09:36,110 --> 05:09:37,745
PRODUCTS, CO USE IS COMMON.

8374
05:09:37,745 --> 05:09:40,981
THIS TABLE SHOWS DKRRK CPS

8375
05:09:40,981 --> 05:09:43,050
UNPUBLISHED 2015 TO 2019 IS THE

8376
05:09:43,050 --> 05:09:44,919
DATA, OF ADULT PAST MONTH

8377
05:09:44,919 --> 05:09:47,054
CONTROL CIGARETTE AND CANNABIS

8378
05:09:47,054 --> 05:09:47,521
USE.

8379
05:09:47,521 --> 05:09:50,591
OVER ALL CANNABIS USE IS

8380
05:09:50,591 --> 05:09:52,026
INCREASING AND WE WE'VE SEEN AN

8381
05:09:52,026 --> 05:09:54,094
INCREASE IN TREND IN CO USE OF

8382
05:09:54,094 --> 05:09:59,466
ALCOHOL AND CANNABIS AND

8383
05:09:59,466 --> 05:10:00,534
CIGARETTES AND KAN--KANA

8384
05:10:00,534 --> 05:10:01,068
BUSINESS PROGRAMS.

8385
05:10:01,068 --> 05:10:03,170
BEYOND HEALTH CO USE CAN HAVE

8386
05:10:03,170 --> 05:10:04,538
NEG5 OUTCOMES, FOR EXAMPLE,

8387
05:10:04,538 --> 05:10:06,574
CONTROL USE AMONG PEOPLE WHO

8388
05:10:06,574 --> 05:10:08,409
SMOKE CIGARETTE SYSTEM SOCKED

8389
05:10:08,409 --> 05:10:09,610
WITH LOWER SMOKING QUIT RATES

8390
05:10:09,610 --> 05:10:12,246
AND HIGHER RATES OF SMOKING

8391
05:10:12,246 --> 05:10:12,479
RELAPSE.

8392
05:10:12,479 --> 05:10:14,648
SO UNDERSTANDING BOTH USE AND CO

8393
05:10:14,648 --> 05:10:17,218
USE IS IMPORTANT FOR CANCER

8394
05:10:17,218 --> 05:10:17,718
PREVENTION AND CONTROL.

8395
05:10:17,718 --> 05:10:19,653
WE DO MOT HAVE MUCH DID THEA ON

8396
05:10:19,653 --> 05:10:21,355
THE COMBINED HEALTH EFFECTS OF

8397
05:10:21,355 --> 05:10:21,889
CO USE.

8398
05:10:21,889 --> 05:10:25,459
BUT WE DO KNOW THAT TOBACCO AND

8399
05:10:25,459 --> 05:10:26,627
ALCOHOLLOR INDIVIDUALLY HARMFUL,

8400
05:10:26,627 --> 05:10:28,929
AS SHEEN HERE, TOBACCO AND

8401
05:10:28,929 --> 05:10:30,231
ALCOHOL CAUSE NUMEROUS TYPES OF

8402
05:10:30,231 --> 05:10:32,166
CANCER, IN THE U.S. COMBINED

8403
05:10:32,166 --> 05:10:35,102
TOBACCO AND ALCOHOL CAUSE 130 OF

8404
05:10:35,102 --> 05:10:36,370
CANCER DEATHS.

8405
05:10:36,370 --> 05:10:38,305
DATA ON HEALTH EFFECTS OF

8406
05:10:38,305 --> 05:10:39,406
CANNABIS ARE LIMITED BUT THE

8407
05:10:39,406 --> 05:10:42,042
SMOKING IS THE MOST COMMON MODE

8408
05:10:42,042 --> 05:10:44,311
OF CANNABIS ADMINITRATION WITH

8409
05:10:44,311 --> 05:10:45,312
78.4% OF KAN--KANA BUSINESS

8410
05:10:45,312 --> 05:10:46,680
PROGRAMS USERS 12 AND OLDER

8411
05:10:46,680 --> 05:10:47,948
REPORRING THEY HAD SMOKED CANC

8412
05:10:47,948 --> 05:10:49,884
BUSINESS PROGRAMS IN THE LAST

8413
05:10:49,884 --> 05:10:53,587
YEAR AND WE KNOW INHALING

8414
05:10:53,587 --> 05:10:54,388
COMBUSTIBLE SUBSTANCES AND

8415
05:10:54,388 --> 05:10:54,722
HARMFUL.

8416
05:10:54,722 --> 05:10:55,556
THE APPROXIMATELY SEE

8417
05:10:55,556 --> 05:10:56,590
ENVIRONMENT FOR THESE 3

8418
05:10:56,590 --> 05:10:59,226
SUBSTANCES AND ALSO CHANGING

8419
05:10:59,226 --> 05:11:00,027
RAPIDLY.

8420
05:11:00,027 --> 05:11:01,662
SINCE 2012, WE'VE SEEN

8421
05:11:01,662 --> 05:11:02,963
LEGALIZATION OF RECREATIONAL

8422
05:11:02,963 --> 05:11:05,132
CANNABIS IN 24 STATES, 2

8423
05:11:05,132 --> 05:11:08,535
TERRITORIES AND  C. BUT POLICIES

8424
05:11:08,535 --> 05:11:10,871
MAY NOT HAVE THE INTENDED REACH

8425
05:11:10,871 --> 05:11:13,807
OR POPULATIONS EQUALLY, FOR

8426
05:11:13,807 --> 05:11:14,708
EXAMPLE, IN OKLAHOMA, MEDICAL

8427
05:11:14,708 --> 05:11:15,576
KAN--KANA BUSINESS PROGRAMS USE

8428
05:11:15,576 --> 05:11:16,977
IS LEGAL, ZOOM NOTHING THE TO

8429
05:11:16,977 --> 05:11:19,179
GRAPHIC ON THE RIGHT FROM A

8430
05:11:19,179 --> 05:11:20,314
STUDY PUBLISHED LAST YEAR,

8431
05:11:20,314 --> 05:11:21,916
KAN--KANA BUSINESS PROGRAMS

8432
05:11:21,916 --> 05:11:23,918
DISPENSARYS IN OKLAHOMA WERE

8433
05:11:23,918 --> 05:11:25,686
DISPROPORTIONATELY LOCATED IN

8434
05:11:25,686 --> 05:11:26,720
AREAS WITH GREATER DISADVANTAGE

8435
05:11:26,720 --> 05:11:28,455
SPECIFICALLY IN AREAS WITH A

8436
05:11:28,455 --> 05:11:30,691
HIGHER PERCENTAGE OF UNINSURED

8437
05:11:30,691 --> 05:11:34,261
RESIDENTS AND NO FORMACYS AND

8438
05:11:34,261 --> 05:11:35,429
SUGGESTING CANNABIS RETAILERS

8439
05:11:35,429 --> 05:11:36,697
MAY TAKE ADVANTAGE OF

8440
05:11:36,697 --> 05:11:39,099
COMMUNITIES WITH LIMITED

8441
05:11:39,099 --> 05:11:40,100
HEALTHCARE ACCESS.

8442
05:11:40,100 --> 05:11:41,168
SO SCIENCE BASED POLICY

8443
05:11:41,168 --> 05:11:43,103
APPROACHES ARE A KEY PUBLIC

8444
05:11:43,103 --> 05:11:44,738
HEALTH TOOL BECAUSE THEY CAN BE

8445
05:11:44,738 --> 05:11:45,673
WIDE REACHING AND COST

8446
05:11:45,673 --> 05:11:46,040
EFFECTIVE.

8447
05:11:46,040 --> 05:11:48,142
THEY HAVE THE POTENTIAL TO

8448
05:11:48,142 --> 05:11:50,010
PROMOTE HEALTH EQUITY BY

8449
05:11:50,010 --> 05:11:51,512
REDUCING HEALTH DISPARITIES FOR

8450
05:11:51,512 --> 05:11:53,013
EXAMPLE, LOWER INCOME

8451
05:11:53,013 --> 05:11:54,481
POPULATIONS OFTEN RESPOND MORE

8452
05:11:54,481 --> 05:11:57,217
TO TO BACK O TAX AND PRICE

8453
05:11:57,217 --> 05:12:00,087
INCREASES THAN HIGHER INCOME

8454
05:12:00,087 --> 05:12:02,389
POPULATIONS, OR A POLICY MAY

8455
05:12:02,389 --> 05:12:04,825
HAVE UNANTICIPATED OR UNINTENDED

8456
05:12:04,825 --> 05:12:08,095
CONESQUENCES OR BE COUNSEL RIGHT

8457
05:12:08,095 --> 05:12:09,229
NEGLIGENT WORSENING HEALTH

8458
05:12:09,229 --> 05:12:11,165
DISPARITIES FOR EXAMPLE, EVEN

8459
05:12:11,165 --> 05:12:13,233
WHEN SMOKE FREE POLICIES ARE IN

8460
05:12:13,233 --> 05:12:14,768
EFFECT, SECOND HAND TOBACCO

8461
05:12:14,768 --> 05:12:17,538
EXPOSURE IS HIGHER AMONG CERTAIN

8462
05:12:17,538 --> 05:12:18,572
GROUPS INCLUDING CHILDREN,

8463
05:12:18,572 --> 05:12:19,640
NONHISPANIC PLAQUE BEAM, PEOPLE

8464
05:12:19,640 --> 05:12:22,042
WITH LOWER INCOMES AND PEOPLE

8465
05:12:22,042 --> 05:12:22,776
WITH LESS EDUCATION.

8466
05:12:22,776 --> 05:12:24,478
MORE OVER BECAUSE WE KNOW THAT

8467
05:12:24,478 --> 05:12:26,480
PATTERNS OF USE FOR 33

8468
05:12:26,480 --> 05:12:28,782
SUBSTANCES CAN BE COMPLEX, WE

8469
05:12:28,782 --> 05:12:30,818
ANTICIPATE THAT POLICIES THAT

8470
05:12:30,818 --> 05:12:31,785
PERTAIN TO 1 SUBSTANCE WILL

8471
05:12:31,785 --> 05:12:35,089
IMPACT USE OF OTHER SUBSTANCES

8472
05:12:35,089 --> 05:12:37,057
ON A POPULATION LEVEL THROUGH CO

8473
05:12:37,057 --> 05:12:38,125
USE, SUBSIDIARY CONSTITUTION OR

8474
05:12:38,125 --> 05:12:38,726
IN OTHER WAYS.

8475
05:12:38,726 --> 05:12:42,162
FOR EXAMPLE, IN A HIGH TOBACCO

8476
05:12:42,162 --> 05:12:44,365
TAX AREA, IF RECREATIONAL

8477
05:12:44,365 --> 05:12:46,633
CANNABIS AND LEGALIZED AND THE

8478
05:12:46,633 --> 05:12:49,303
CANNABIS TAXES ARE LOW FOR THE

8479
05:12:49,303 --> 05:12:51,105
CONSUMER WE MAY SEE INDIVIDUALS

8480
05:12:51,105 --> 05:12:52,106
SUBSTITUTING CANCA BUSINESS

8481
05:12:52,106 --> 05:12:53,140
PROGRAMS FOR TOBACCO, THE SPEED

8482
05:12:53,140 --> 05:12:55,576
WE SEE THE CHANGE IS EXCITING

8483
05:12:55,576 --> 05:12:57,778
AND CONCERNING AND UNDERSCORES

8484
05:12:57,778 --> 05:13:01,215
THE NEED TO EVALUATE THE HEALTH

8485
05:13:01,215 --> 05:13:03,250
EQUITY IMPACT ON THESE

8486
05:13:03,250 --> 05:13:03,717
SUBSTANCES.

8487
05:13:03,717 --> 05:13:06,253
FOR THIS SET OF PARS, RESPONSIVE

8488
05:13:06,253 --> 05:13:07,988
RESEARCH QUESTIONS MUST ADDRESS

8489
05:13:07,988 --> 05:13:12,993
1 OR MORE POLICIES PERTAINING TO

8490
05:13:12,993 --> 05:13:14,828
POETIC TOBACCO, WHOLE OR

8491
05:13:14,828 --> 05:13:16,597
CANNABIS AND EXPOSURE MIEWOF THE

8492
05:13:16,597 --> 05:13:19,600
SHOW ECPOSURE OR USE FOR ALL 3

8493
05:13:19,600 --> 05:13:21,468
SUBSTANCES, THERE ARE NO TYPES

8494
05:13:21,468 --> 05:13:25,339
OF LIMITS, FOR RESEARCHERS MAY

8495
05:13:25,339 --> 05:13:26,840
PROPOSED RANDOMIZED TRIALS,

8496
05:13:26,840 --> 05:13:28,342
MODELING STUDIES, THE ONLY

8497
05:13:28,342 --> 05:13:29,643
EXCLUSION ON BIOLOGICAL

8498
05:13:29,643 --> 05:13:31,178
MECHANISMS OR DISEASE PROCESSES,

8499
05:13:31,178 --> 05:13:33,814
SO FOR EXAMPLE, A LABORATORY

8500
05:13:33,814 --> 05:13:34,848
BASED EXPERIMENTAL MARKETPLACE

8501
05:13:34,848 --> 05:13:37,651
STUDY COULD PROPOSE EXAMINING

8502
05:13:37,651 --> 05:13:40,854
TOBACCO FLAVOR RESTRICTIONS WITH

8503
05:13:40,854 --> 05:13:42,089
NO FLAVOR CANNABIS RESTRICTIONS

8504
05:13:42,089 --> 05:13:43,057
TO UNDERSTAND PURCHASING

8505
05:13:43,057 --> 05:13:44,792
BEHAVIOR AND USE, MOST

8506
05:13:44,792 --> 05:13:45,959
IMPORTANTLY, THE RESEARCH MUST

8507
05:13:45,959 --> 05:13:48,495
EVALUATE THIS IN THE CONTEXT OF

8508
05:13:48,495 --> 05:13:50,164
HOW THE POLICY INFLUENCES HEALTH

8509
05:13:50,164 --> 05:13:52,633
DISPARITIES AND WOB OR MORE

8510
05:13:52,633 --> 05:13:53,133
POPULATIONS EXPERIENCING

8511
05:13:53,133 --> 05:13:53,434
DISPARITIES.

8512
05:13:53,434 --> 05:13:56,003
AND THESE GROUPS ARE DEFINED BY

8513
05:13:56,003 --> 05:13:58,005
NIH AND INCLUDE RACIAL AND

8514
05:13:58,005 --> 05:13:58,939
ETHNIC MINORITY GROUPS, PEOPLE

8515
05:13:58,939 --> 05:14:02,142
WITH LOW CERTAINLY--CERTAINLY

8516
05:14:02,142 --> 05:14:03,444
SES, UNDERSERVED RURAL POP

8517
05:14:03,444 --> 05:14:04,645
EULOGIES, SEXUAL AND GENDER

8518
05:14:04,645 --> 05:14:06,513
MINORITY GROUPS AND PEOPLE WITH

8519
05:14:06,513 --> 05:14:07,081
DISABILITIES, LASTLY THE

8520
05:14:07,081 --> 05:14:08,816
RESEARCH MUST BE CONDUCT INDEED

8521
05:14:08,816 --> 05:14:10,350
PARTNERSHIP WITH THE COMMUNITY

8522
05:14:10,350 --> 05:14:11,418
ORGANIZATION, WHICH WILL HELP

8523
05:14:11,418 --> 05:14:13,020
INFORM THE RESEARCH QUESTIONS,

8524
05:14:13,020 --> 05:14:14,955
SHAPE THE APPROACH AND

8525
05:14:14,955 --> 05:14:15,789
DISSEMINATE FINDINGS.

8526
05:14:15,789 --> 05:14:16,657
AS AN EXAMPLE, RESEARCH HAS

8527
05:14:16,657 --> 05:14:18,926
SHOWN THAT THERE IS A

8528
05:14:18,926 --> 05:14:21,128
SIGNIFICANT ASSOCIATION BETWEEN

8529
05:14:21,128 --> 05:14:22,496
NEIGHBORHOOD DISADVANTAGE AND

8530
05:14:22,496 --> 05:14:25,866
ALCOHOL AND TOBACCO RETAIL

8531
05:14:25,866 --> 05:14:26,333
OUTLET RATES.

8532
05:14:26,333 --> 05:14:27,334
ONE COULD WORK WITH COMMUNITIES

8533
05:14:27,334 --> 05:14:29,570
TO UNDERSTAND HOW A POLICY

8534
05:14:29,570 --> 05:14:31,805
RESTRICTING ALCOHOL RETAIL

8535
05:14:31,805 --> 05:14:33,140
LICENSING MAY BE IMPLEMENTED AND

8536
05:14:33,140 --> 05:14:35,209
IMPACT USE AND EXPOSURE AMONG

8537
05:14:35,209 --> 05:14:37,744
INDIVIDUALS LIVING IN THESE

8538
05:14:37,744 --> 05:14:38,512
NEIGHBORHOODS.

8539
05:14:38,512 --> 05:14:39,546
THESE FUNDING OPPORTUNITIES

8540
05:14:39,546 --> 05:14:41,081
COULD SUPPORT A WIDE RANGE OF

8541
05:14:41,081 --> 05:14:42,483
POLICY RESEARCH QUESTIONS WITH

8542
05:14:42,483 --> 05:14:46,086
IMPORTANT IMPLICATIONS FOR

8543
05:14:46,086 --> 05:14:47,154
CANCER PREVENTION AND CONTROL.

8544
05:14:47,154 --> 05:14:49,656
I WANT THANK OUR REVIEW

8545
05:14:49,656 --> 05:14:51,291
COMMITTEE FOR THEIR THOUGHTFUL

8546
05:14:51,291 --> 05:14:52,126
AND ENCOURAGING FEEDBACK ON THIS

8547
05:14:52,126 --> 05:14:53,894
CONCEPT AND I WILL GIVE A BRIEF

8548
05:14:53,894 --> 05:14:54,795
OVERVIEW OF THEIR MAJOR COMMENTS

8549
05:14:54,795 --> 05:14:56,830
AND HOW WE PLAN TO INCORPORATE

8550
05:14:56,830 --> 05:14:58,565
THESE INTO THE FINAL PARS.

8551
05:14:58,565 --> 05:15:01,802
FIRST THE COMMITTEE NOTED WE MAY

8552
05:15:01,802 --> 05:15:02,569
HAVE OVERSTATED CANNABIS'

8553
05:15:02,569 --> 05:15:04,138
ASSOCIATION WITH CANCER AND WE

8554
05:15:04,138 --> 05:15:05,539
WANT TO CLARIFY THAT THE

8555
05:15:05,539 --> 05:15:06,740
CONSEQUENCES OF LONG-TERM USE OR

8556
05:15:06,740 --> 05:15:08,675
HIGHER LEVELS OF USE ARE

8557
05:15:08,675 --> 05:15:09,176
UNCLEAR.

8558
05:15:09,176 --> 05:15:10,744
USE OF CANNABIS IS INCREASING

8559
05:15:10,744 --> 05:15:12,779
AND CO USE OF CANNABIS WITH

8560
05:15:12,779 --> 05:15:14,548
TOBACCO AND CONTROL AND ALSO

8561
05:15:14,548 --> 05:15:15,249
INCREASING.

8562
05:15:15,249 --> 05:15:16,884
WE ARE ALSO--WE WERE ALSO POSING

8563
05:15:16,884 --> 05:15:18,485
QUESTIONS TO HELP US THINK

8564
05:15:18,485 --> 05:15:20,254
THROUGH THE COMMUNITY

8565
05:15:20,254 --> 05:15:20,954
PARTNERSHIP COMPONENT, IN

8566
05:15:20,954 --> 05:15:22,789
RESPONSE WE WILL INCLUDE IN THE

8567
05:15:22,789 --> 05:15:23,724
PARS EXAMPLES OF COMMUNITY

8568
05:15:23,724 --> 05:15:26,059
ENGAGE EXPMENT THAT WE ENCOURAGE

8569
05:15:26,059 --> 05:15:28,195
INCLUSION OF WORKFORCE

8570
05:15:28,195 --> 05:15:29,363
DEVELOPMENT PLANS AND AN

8571
05:15:29,363 --> 05:15:31,598
EXPECTATION OF INVOLVEMENT FROM

8572
05:15:31,598 --> 05:15:32,499
CONCEPTION TO DISSEMINATION

8573
05:15:32,499 --> 05:15:35,369
WITHIN THE COMMUNITY PARTNERSHIP

8574
05:15:35,369 --> 05:15:37,738
LANGUAGE, AND UNRELATEDLY WE

8575
05:15:37,738 --> 05:15:38,906
WILL INCLUDE LANGUAGE SIS

8576
05:15:38,906 --> 05:15:40,741
SEMESTER NATION TO COMMUNITY

8577
05:15:40,741 --> 05:15:42,142
PARTNERS AND COMMUNITIES, SHOULD

8578
05:15:42,142 --> 05:15:43,744
BE APPROPRIATE TO THE SCALE AND

8579
05:15:43,744 --> 05:15:45,379
SCOPE OF THE RESEARCH QUESTION,

8580
05:15:45,379 --> 05:15:49,383
THE STUDY POPULATION AND THE

8581
05:15:49,383 --> 05:15:50,017
RESEARCH FINDINGS.

8582
05:15:50,017 --> 05:15:51,485
WITHIN THE P A R WE WILL

8583
05:15:51,485 --> 05:15:53,220
ENCOURAGE CONSIDERATION OF THE

8584
05:15:53,220 --> 05:15:55,055
OVERARCHING CONTEXT AND

8585
05:15:55,055 --> 05:15:56,356
POTENTIAL MODERATORS AT PLAY,

8586
05:15:56,356 --> 05:15:57,391
FOR EXAMPLE, OTHER POLICIES THAT

8587
05:15:57,391 --> 05:16:00,227
MAY BE IN EFFECT, POLICY

8588
05:16:00,227 --> 05:16:01,395
ENFORCEMENT, AND EVEN POLICIES

8589
05:16:01,395 --> 05:16:02,896
RELATED TO METHODS OF PRODUCT

8590
05:16:02,896 --> 05:16:05,199
USE SUCH AS VAPING, OR THE

8591
05:16:05,199 --> 05:16:09,036
IMPACT OF POLICY ON THE MODE OF

8592
05:16:09,036 --> 05:16:10,671
SUBSTANCE ADMINISTRATION EVEN.

8593
05:16:10,671 --> 05:16:12,472
THESE CONTEXTURAL FACTORS OF

8594
05:16:12,472 --> 05:16:14,274
IMPORTANCE WILL DEPEND VARY ON

8595
05:16:14,274 --> 05:16:17,044
THE RESEARCH PER POST.

8596
05:16:17,044 --> 05:16:19,479
AND THE VARIABLES ARE ALCOHOL,

8597
05:16:19,479 --> 05:16:21,715
TOBACCO AND CANNABIS EXPOSURE

8598
05:16:21,715 --> 05:16:24,117
FOR USE, WE WILL CLARIFY THAT

8599
05:16:24,117 --> 05:16:25,986
ALL PROJECTS MIEWOF THE INCLUDE

8600
05:16:25,986 --> 05:16:27,654
THIS IN THE PARAND REVIEW

8601
05:16:27,654 --> 05:16:29,156
CRITERIA AS APPROPRIATE, WE WILL

8602
05:16:29,156 --> 05:16:34,795
ALSO INCLUDE HEALTH  HELT OUTCOR

8603
05:16:34,795 --> 05:16:36,163
THE PROJECT PROPOSED.

8604
05:16:36,163 --> 05:16:38,198
WE WILL SIN THAT SPECIAL

8605
05:16:38,198 --> 05:16:39,600
CRITERIA WILL ASK IF THE

8606
05:16:39,600 --> 05:16:40,200
DISSEMINATION PLAN IS

8607
05:16:40,200 --> 05:16:40,834
APPROPRIATE FOR THE RESEARCH

8608
05:16:40,834 --> 05:16:44,605
QUESTION AND THE NATURE OF THE

8609
05:16:44,605 --> 05:16:45,739
RESULTS.

8610
05:16:45,739 --> 05:16:47,040
THE DISSEMINATION OF PRELIMINARY

8611
05:16:47,040 --> 05:16:48,342
EVIDENCE CAN AND SHOULD DIFFER

8612
05:16:48,342 --> 05:16:50,477
FROM THE REPEATED FINDINGS, ALSO

8613
05:16:50,477 --> 05:16:53,046
EXAM NATION OF A SINGLE

8614
05:16:53,046 --> 05:16:53,580
POPULATION EXPERIENCING

8615
05:16:53,580 --> 05:16:55,515
DISPARITIES MAY NOT BE THE SAME

8616
05:16:55,515 --> 05:16:56,550
AS RECOLLECT POPULATIONS, WE

8617
05:16:56,550 --> 05:16:59,453
WILL ALSO INSURE THAT THE REVIEW

8618
05:16:59,453 --> 05:17:03,123
CRITERIA ASKS REVIEWERS TO

8619
05:17:03,123 --> 05:17:04,791
ASSESS DISPARATE POPULATION

8620
05:17:04,791 --> 05:17:05,759
UNDERSTUDY IS A APPROPRIATE.

8621
05:17:05,759 --> 05:17:07,628
WE RECOGNIZE THAT THIS IS A

8622
05:17:07,628 --> 05:17:08,962
COMPLEX QUESTION, AND AS I

8623
05:17:08,962 --> 05:17:09,930
HIGHLIGHTED EARLIER, WE WILL

8624
05:17:09,930 --> 05:17:12,466
RELY ON THE NIH DEFINITION OF

8625
05:17:12,466 --> 05:17:14,101
POPULATIONS WITH HEALTH

8626
05:17:14,101 --> 05:17:18,438
DISPARITIES, AND ENCOURAGE EXAM

8627
05:17:18,438 --> 05:17:19,940
NATION OF INTERSECTIONALITY.

8628
05:17:19,940 --> 05:17:22,709
THESE PARS WILL INDICATE NCI'S

8629
05:17:22,709 --> 05:17:23,877
KAN--KANAER PREVENTION THROUGH

8630
05:17:23,877 --> 05:17:25,045
POLICY RESEARCH FOCUSING ON

8631
05:17:25,045 --> 05:17:26,446
HEALTH DISPARITIES TO REDUCE THE

8632
05:17:26,446 --> 05:17:28,148
USE OF EXPOSURE AND SUBSTANCES

8633
05:17:28,148 --> 05:17:29,750
THAT ARE IMPORTANT TO CANCER

8634
05:17:29,750 --> 05:17:30,417
PREVENTION, ULTIMATELY HAVING A

8635
05:17:30,417 --> 05:17:31,051
LARGE CENTER FOR EXCELLENCE ON

8636
05:17:31,051 --> 05:17:33,120
AGING ON USE CANCER RELATED

8637
05:17:33,120 --> 05:17:33,687
MORIT AND MORTALITY.

8638
05:17:33,687 --> 05:17:35,322
I WOULD LIKE TO OPEN IT UP FOR

8639
05:17:35,322 --> 05:17:35,922
COMMENT ANDS QUESTIONS AND

8640
05:17:35,922 --> 05:17:43,597
THAIRNG YOU FOR YOUR ATTENTION.

8641
05:17:43,597 --> 05:17:44,431
NTHE COMMITTEE REPORT?

8642
05:17:44,431 --> 05:17:45,565
, YES, THANK YOU.

8643
05:17:45,565 --> 05:17:47,567
THANK YOU DR. KAUFMAN, THAT WAS

8644
05:17:47,567 --> 05:17:48,602
VERY NICE PRESENTATION AND I

8645
05:17:48,602 --> 05:17:55,375
ALSO THANK YOU SO MUCH FOR BEING

8646
05:17:55,375 --> 05:17:57,744
SO RESPONSIVE TO THE COMMENTS TO

8647
05:17:57,744 --> 05:18:00,147
THE COMMITTEE.

8648
05:18:00,147 --> 05:18:05,152
WE, THE SUBCOMMITTEE MERELY WAS

8649
05:18:05,152 --> 05:18:08,755
FULLY SUPPORTIVE OF THIS

8650
05:18:08,755 --> 05:18:09,523
PARTICULAR PAR.

8651
05:18:09,523 --> 05:18:12,526
WE THOUGHT THAT TOO OFTEN

8652
05:18:12,526 --> 05:18:16,129
POLICIES ARE EXAMINED IN

8653
05:18:16,129 --> 05:18:17,197
ISOLATION AND NOT CONSIDERED

8654
05:18:17,197 --> 05:18:20,367
WHAT THE IMPACT OF THIS POLICY

8655
05:18:20,367 --> 05:18:21,668
AND A SPECIFIC SUBSTANCE HAS ON

8656
05:18:21,668 --> 05:18:26,306
THE USE OF OTHER SUBSTANCES SO

8657
05:18:26,306 --> 05:18:29,309
WE REALLY FELT THIS WAS QUITE

8658
05:18:29,309 --> 05:18:30,677
IMPORTANT ESPECIALLY IN THE

8659
05:18:30,677 --> 05:18:32,846
CURRENT MARKETPLACE, WHERE WE

8660
05:18:32,846 --> 05:18:34,581
HAVE SUCH A CORNUCOPIA OF

8661
05:18:34,581 --> 05:18:36,583
DIFFERENT KINDS OF PRODUCTS.

8662
05:18:36,583 --> 05:18:37,951
IF YOU EVEN THINK ABOUT STAFF

8663
05:18:37,951 --> 05:18:39,486
THOUGH, WE HAVE ALL THESE

8664
05:18:39,486 --> 05:18:41,088
DIFFERENT KINDS OF DEVICES

8665
05:18:41,088 --> 05:18:43,490
COMING IN DIFFERENT DOSES AND

8666
05:18:43,490 --> 05:18:44,858
DIFFERENT FLAVORS, AND YOU ALSO

8667
05:18:44,858 --> 05:18:47,094
THINK ABOUT THE CANNABIS MARKET,

8668
05:18:47,094 --> 05:18:48,695
TOO, THAT ARE SIMILARLY, THEY

8669
05:18:48,695 --> 05:18:55,702
COME IN DIFFERENT TYPES OF THC

8670
05:18:55,702 --> 05:18:57,437
CONTAINING PRODUCTS AND WITH ALL

8671
05:18:57,437 --> 05:18:59,272
KINDS OF DIFFERENT FLAVORS, SO

8672
05:18:59,272 --> 05:19:02,209
WE ARE REALLY IN THIS

8673
05:19:02,209 --> 05:19:04,778
ENVIRONMENT WHERE WE HAVE SUCH A

8674
05:19:04,778 --> 05:19:07,948
DIVERSITY OF PRODUCTS AND AS A

8675
05:19:07,948 --> 05:19:10,250
CONSEQUENCE, CONSEQUENCE WE ALSO

8676
05:19:10,250 --> 05:19:14,121
HAVE A RAPIDLY CHANGING

8677
05:19:14,121 --> 05:19:14,821
REGULATORY POLICY ENVIRONMENT

8678
05:19:14,821 --> 05:19:16,390
AND SO REALLY TAKING A LOOK AT

8679
05:19:16,390 --> 05:19:20,727
THESE CAREFULLY AND SEEING ANY

8680
05:19:20,727 --> 05:19:21,895
POTENTIAL UNINTENDED

8681
05:19:21,895 --> 05:19:22,896
CONSEQUENCES OF 1 POLICY AND HOW

8682
05:19:22,896 --> 05:19:27,534
IT AFFECTS THE USE OF OTHERS

8683
05:19:27,534 --> 05:19:29,169
SUBSTANCES IS BECOMING VERY

8684
05:19:29,169 --> 05:19:30,137
CRITICAL.

8685
05:19:30,137 --> 05:19:32,172
IN ADDITION IT'S DR. KAUFMAN HAD

8686
05:19:32,172 --> 05:19:34,674
POINTED OUT, THERE IS AN

8687
05:19:34,674 --> 05:19:37,811
INCREASE IN TERMS OF COLLEAGUES,

8688
05:19:37,811 --> 05:19:38,712
KD--SALLY WAAND SO WE NEED IT ON

8689
05:19:38,712 --> 05:19:46,386
GET ON TOP OF THAT AND MINIMIZE

8690
05:19:46,386 --> 05:19:48,889
THE TREND TOWARDS HIGHER

8691
05:19:48,889 --> 05:19:55,762
PREVALENCE OF MULTIPLE SUBSTANCE

8692
05:19:55,762 --> 05:19:55,929
USE.

8693
05:19:55,929 --> 05:20:00,300
SO IN SUMMARY WE WERE VERY

8694
05:20:00,300 --> 05:20:02,102
SUPPORTIVE.

8695
05:20:02,102 --> 05:20:02,502
[INDISCERNIBLE],.

8696
05:20:02,502 --> 05:20:02,969
>> VERY SUPPORTIVE.

8697
05:20:02,969 --> 05:20:04,771
THE INCLUSION OF CANNABIS IS WE

8698
05:20:04,771 --> 05:20:06,139
THOUGHT VERY IMPORTANT BECAUSE

8699
05:20:06,139 --> 05:20:11,478
OF ITS FAST RISING USE AND RAPID

8700
05:20:11,478 --> 05:20:13,680
EVOLUTION OF POLICY IN

8701
05:20:13,680 --> 05:20:14,281
SEVERALITATES, PROVIDES GREAT

8702
05:20:14,281 --> 05:20:22,355
OPPORTUNITY FOR WORK TO BE DONE

8703
05:20:22,355 --> 05:20:23,623
IN THIS SPACE.

8704
05:20:23,623 --> 05:20:24,691
VERY RESPONSIVE OF THESE

8705
05:20:24,691 --> 05:20:28,428
THOUGHTS, VERY INTERESTED IN

8706
05:20:28,428 --> 05:20:31,064
YOUR DESIRE TO ECHICIZE

8707
05:20:31,064 --> 05:20:32,632
COMMUNITY ENGAGEMENT AND I HAD

8708
05:20:32,632 --> 05:20:36,369
THOUGHT THAT ALONG WITH THAT,

8709
05:20:36,369 --> 05:20:37,971
AND THE OPPORTUNITY TO

8710
05:20:37,971 --> 05:20:42,476
EMPHASIZING POSSIBILITIES OF

8711
05:20:42,476 --> 05:20:43,076
WORKFORCE DEVELOPMENT WITHIN

8712
05:20:43,076 --> 05:20:44,678
THESE COMMUNITIES YOU ENGAGE IN,

8713
05:20:44,678 --> 05:20:46,446
THANK YOU FOR PUTTING THAT IN

8714
05:20:46,446 --> 05:20:53,253
THERE, OVERALL VERY SUPPORTIVE.

8715
05:20:53,253 --> 05:20:54,020
>> KAREN?

8716
05:20:54,020 --> 05:20:54,754
>> NETWORK YEAH, AGREE,
VERY

8717
05:20:54,754 --> 05:20:55,922
SUPPORTIVE AND 1 OF THE THINGS

8718
05:20:55,922 --> 05:20:57,557
WE TALKED ABOUT THAT WAS KIND OF

8719
05:20:57,557 --> 05:21:00,227
INTERESTING IS WE HOPE FOR THE

8720
05:21:00,227 --> 05:21:02,095
POSITIVE, MAYBE WHEN YOU

8721
05:21:02,095 --> 05:21:03,497
IMPLEMENT 1 POLICY MAYBE IT WILL

8722
05:21:03,497 --> 05:21:04,464
AFFECT THESE BEHAVIORS IN A

8723
05:21:04,464 --> 05:21:05,866
POSITIVE WAY BUT IN THE CURRENT

8724
05:21:05,866 --> 05:21:07,267
ENVIRONMENT WE SEE THIS REALLY

8725
05:21:07,267 --> 05:21:08,201
INTERESTING MIX AND WE TALKED

8726
05:21:08,201 --> 05:21:09,269
ABOUT THE FACT THAT WHILE YOU

8727
05:21:09,269 --> 05:21:11,538
MAY HAVE AN INSTITUTION FOR

8728
05:21:11,538 --> 05:21:14,808
EXAMPLE THAT SAYS WE'RE A

8729
05:21:14,808 --> 05:21:16,309
NONSMOKING FACILITY, YOU SEE

8730
05:21:16,309 --> 05:21:17,711
PEOPLE LINED UP VAPING BECAUSE

8731
05:21:17,711 --> 05:21:20,280
THEY THINK, OH THIS ISN'T

8732
05:21:20,280 --> 05:21:22,315
SMOKING, IT'S VAPING.

8733
05:21:22,315 --> 05:21:26,686
AND SO, SOMETIMES IT CAN HAVE

8734
05:21:26,686 --> 05:21:29,222
THESE SORT OF BACKWARD

8735
05:21:29,222 --> 05:21:29,823
UNINTENDED NEG5 CONSEQUENCES

8736
05:21:29,823 --> 05:21:32,158
THAT WE DON'T WANT TO SEE SO THE

8737
05:21:32,158 --> 05:21:32,959
IMPORTANCE OF ENCOURAGING

8738
05:21:32,959 --> 05:21:34,227
INVESTIGATORS TO MEASURE THOSE

8739
05:21:34,227 --> 05:21:36,963
KINDS OF THINGS AS WELL IS

8740
05:21:36,963 --> 05:21:39,833
NOT'RE WE'RE NOT GOING TO SEE

8741
05:21:39,833 --> 05:21:40,000
IT.

8742
05:21:40,000 --> 05:21:41,835
RIGHT IN NTHIS IS A RAPIDLY

8743
05:21:41,835 --> 05:21:43,370
CHANGING AREA AS PEOPLE POINTED

8744
05:21:43,370 --> 05:21:46,106
OUT WITH POLICIES ARE CHANGING

8745
05:21:46,106 --> 05:21:47,173
ALMOST DAILY.

8746
05:21:47,173 --> 05:21:54,314
OTHER DISCUSSION OF THIS?

8747
05:21:54,314 --> 05:21:54,748
TREY?

8748
05:21:54,748 --> 05:21:56,216
NI THINK MY MAIN QUESTION IS A

8749
05:21:56,216 --> 05:21:57,050
LACK OF UNDERSTANDING OF WHAT

8750
05:21:57,050 --> 05:21:59,452
THIS HAS TO DO WITH CANCER, I

8751
05:21:59,452 --> 05:22:01,922
UNDERSTAND THE RELATION STUDYING

8752
05:22:01,922 --> 05:22:03,757
THE RELATION AMONG STUB STANCES,

8753
05:22:03,757 --> 05:22:05,258
BUT THAT'S SOMETHING NIDA MIGHT

8754
05:22:05,258 --> 05:22:06,760
STUDY SO I'M TRYING TO

8755
05:22:06,760 --> 05:22:08,762
UNDERSTAND WHAT IS THE OUTCOME

8756
05:22:08,762 --> 05:22:11,197
HERE THAT'S DESIRED IN TERMS OF

8757
05:22:11,197 --> 05:22:11,798
CANCER?

8758
05:22:11,798 --> 05:22:15,569
WHAT'S THE POTENTIAL IMPACT IN. 

8759
05:22:15,569 --> 05:22:15,902
>> RIGHT.

8760
05:22:15,902 --> 05:22:17,637
SO, OBVIOUSLY TOBACCO IS THE

8761
05:22:17,637 --> 05:22:18,505
LEADING CAUSE OF CANCER DEATHS

8762
05:22:18,505 --> 05:22:20,807
IN THE UNITED STATES AND THE

8763
05:22:20,807 --> 05:22:24,110
WORLD, AND ALCOHOL IS THE THIRD

8764
05:22:24,110 --> 05:22:24,911
LEADING MODIFIABLE LIFESTYLE

8765
05:22:24,911 --> 05:22:26,212
FACTOR SO IF WE CAN HAVE THE

8766
05:22:26,212 --> 05:22:28,281
BIGGEST BANG FOR OUR BUCK MIGHT

8767
05:22:28,281 --> 05:22:31,318
BE A POLICY THAT MIGHT IMPACT

8768
05:22:31,318 --> 05:22:32,452
THOSE BEHAVIORS.

8769
05:22:32,452 --> 05:22:33,553
IN CONJUNCTION WITH ALCOHOL AND

8770
05:22:33,553 --> 05:22:35,188
DO BACK O WE'RE SEEING AN

8771
05:22:35,188 --> 05:22:37,657
INCREASE IN CO USE WITH CANNABIS

8772
05:22:37,657 --> 05:22:39,459
GIVEN THEITATES THAT ARE

8773
05:22:39,459 --> 05:22:41,294
LEGALIZING BOTH MEDICALLY AND

8774
05:22:41,294 --> 05:22:41,895
RECREATIONALLY.

8775
05:22:41,895 --> 05:22:44,297
SO IF WE CAN CHANGE THESE

8776
05:22:44,297 --> 05:22:45,699
LIFESTYLES, THESE BEHAVIORS, WE

8777
05:22:45,699 --> 05:22:50,337
SHOULD SEE A REDUCTION IN

8778
05:22:50,337 --> 05:22:50,904
CANCER.

8779
05:22:50,904 --> 05:22:52,339
SO IT'S CANCER PREVENTION AT THE

8780
05:22:52,339 --> 05:22:53,440
HEART OF CANCER PREVENTION.

8781
05:22:53,440 --> 05:23:00,246
DOES THAT ANSWER YOUR QUESTION.

8782
05:23:00,246 --> 05:23:02,482
>> IS THERE ANY THAT
EVIDENCE

8783
05:23:02,482 --> 05:23:03,316
CANNABIS CAUSES CANCER.

8784
05:23:03,316 --> 05:23:06,119
NTHERE'S 1 STUDY THAT I KNOW OF,

8785
05:23:06,119 --> 05:23:08,455
NOT A VERY HUGE HE STRONG STUDY

8786
05:23:08,455 --> 05:23:11,858
IS MY UNDERSTANDING OF THE LINK

8787
05:23:11,858 --> 05:23:12,492
TBEEN KAN--KANA BUSINESS

8788
05:23:12,492 --> 05:23:13,994
PROGRAMS SMOKING AND TESTICULAR

8789
05:23:13,994 --> 05:23:21,434
CANCER BUT EVIDENT IS EMERGING

8790
05:23:21,434 --> 05:23:22,369
AND VERY MIXED.

8791
05:23:22,369 --> 05:23:24,170
>> I WASN'T AWARE OF ANY,
AND

8792
05:23:24,170 --> 05:23:25,872
COMBINING THOSE 3 THAT YOU WILL

8793
05:23:25,872 --> 05:23:27,374
BE DEPLETING YOUR REAL PURPOSE

8794
05:23:27,374 --> 05:23:30,844
OF TRYING TO REDUCE ALCOHOL AND

8795
05:23:30,844 --> 05:23:31,778
TOBACCO IN COMBINATION BECAUSE

8796
05:23:31,778 --> 05:23:34,080
THE PUBLIC WILL THINK, WHY ARE

8797
05:23:34,080 --> 05:23:36,049
YOU THROWING IN SOMETHING THAT

8798
05:23:36,049 --> 05:23:37,651
ISN'T CAUSING CANCER BUT I

8799
05:23:37,651 --> 05:23:40,720
ENYOURCANDIDATES IT AND IT MIGHT

8800
05:23:40,720 --> 05:23:45,925
ACTUALLY BE COUNTER PRODUCTIVE.

8801
05:23:45,925 --> 05:23:47,594
>> SO I'M GOING TO
PIGGYBACK OFF

8802
05:23:47,594 --> 05:23:47,794
THAT.

8803
05:23:47,794 --> 05:23:55,001
SO I EMBASSY JUST THE KEV DITION

8804
05:23:55,001 --> 05:23:57,604
OF TOBACCO IS IT COMBUSTIBLE, SO

8805
05:23:57,604 --> 05:23:59,639
LIKE CIGARETTES ET CETERA, THE

8806
05:23:59,639 --> 05:24:01,908
SAME CANCER ABOUT CANCER RISK SO

8807
05:24:01,908 --> 05:24:03,677
THAT MADE ME THINK MAYBE THERE

8808
05:24:03,677 --> 05:24:09,149
SHOULD BE A HIERARCHY IN HERE,

8809
05:24:09,149 --> 05:24:10,316
COMBUSTIBLE TOBACCO, ALCOHOL,

8810
05:24:10,316 --> 05:24:11,685
CANCER RISKS, THE OTHERS MAYBE

8811
05:24:11,685 --> 05:24:14,754
NOT AS MAJOR BUT CO INTERACT

8812
05:24:14,754 --> 05:24:16,423
WITH THOSE SO, JUST IN TERMS OF

8813
05:24:16,423 --> 05:24:18,425
HOW YOU STRUCTURE, HOW YOU'RE

8814
05:24:18,425 --> 05:24:20,160
LOOKING AT DEPEND AND

8815
05:24:20,160 --> 05:24:20,994
INDEPENDENT DEPENDENT VARIABLES

8816
05:24:20,994 --> 05:24:21,795
MIGHT BE IMPORTANT WHEN YOU

8817
05:24:21,795 --> 05:24:24,631
THINK ABOUT THE RFA.

8818
05:24:24,631 --> 05:24:26,032
>> GOING TO THE OTHER END
OF THE

8819
05:24:26,032 --> 05:24:26,366
TABLE.

8820
05:24:26,366 --> 05:24:27,333
>> YOU KNOW I CAN BE THE
HELP

8821
05:24:27,333 --> 05:24:29,502
BUT ARK GREE WITH MY COLLEAGUES

8822
05:24:29,502 --> 05:24:30,704
FROM SAN DIEGO BECAUSE I THINK

8823
05:24:30,704 --> 05:24:33,540
IT IS JUMPING THE GUN.

8824
05:24:33,540 --> 05:24:35,175
BY MAKING AN ARK SUSMGZ THAT

8825
05:24:35,175 --> 05:24:37,911
CANNABIS MIGHT HAVE ADDADDATIVE

8826
05:24:37,911 --> 05:24:39,779
EFFECT TO LEAD TO CANCER BUT

8827
05:24:39,779 --> 05:24:41,181
THAT BEING SAID, I THINK IT'S

8828
05:24:41,181 --> 05:24:42,382
GREAT, I THINK IT'S BOLD, I

8829
05:24:42,382 --> 05:24:44,017
THINK IT'S A GREAT INITIATIVE,

8830
05:24:44,017 --> 05:24:45,652
LET'S JUST TRY IT, YOU NEVER

8831
05:24:45,652 --> 05:24:46,753
KNOW WE MIGHT FIND SOMETHING

8832
05:24:46,753 --> 05:24:48,221
FROM IT, DO I THINK IT'S

8833
05:24:48,221 --> 05:24:50,056
APPROPRIATE FOR WHAT WE'RE

8834
05:24:50,056 --> 05:24:52,092
DOING, MAYBE NOT, I AGREE WUIME

8835
05:24:52,092 --> 05:24:55,061
OKAY WITH IT, I THINK IT'S

8836
05:24:55,061 --> 05:25:05,405
PRETTY BOLD EMPLOY NTHANK YOU.

8837
05:25:05,405 --> 05:25:07,273
THIS, I DO KNOW 1 ASSOCIATION

8838
05:25:07,273 --> 05:25:09,976
STUDY BETWEEN HEAD AND NECK

8839
05:25:09,976 --> 05:25:11,144
CANCER WITH CANNABIS BUT THAT

8840
05:25:11,144 --> 05:25:13,947
WAS ALSO WITH HPV INFECTION, BUT

8841
05:25:13,947 --> 05:25:20,453
THE COMMENT I WANTED TO MAKE

8842
05:25:20,453 --> 05:25:21,955
ABOUT MEASURES, IS THAT FOR THE

8843
05:25:21,955 --> 05:25:24,991
FIRST TIME IN OUR CLINICS IN

8844
05:25:24,991 --> 05:25:26,259
MEMORIAL SLOAN KETTERRING WE'VE

8845
05:25:26,259 --> 05:25:30,163
SEEN A STEEP DECLINE IN VISITS,

8846
05:25:30,163 --> 05:25:31,431
BUT FOR THORACIC ONCOLOGY NOT

8847
05:25:31,431 --> 05:25:33,833
ONLY IN MEDICAL ONCOLOGY BUT

8848
05:25:33,833 --> 05:25:36,035
ALSO IN SURGICAL ONCOLOGY AND

8849
05:25:36,035 --> 05:25:37,070
I'VE ANECDOTALLY GONE AROUND THE

8850
05:25:37,070 --> 05:25:38,238
COUNTRY TO TALK TO MY COLLEAGUES

8851
05:25:38,238 --> 05:25:39,873
AND THAT HAS ALSO BEEN SEEN IN

8852
05:25:39,873 --> 05:25:41,508
OTHER COUNTRIES AND THEN MOST

8853
05:25:41,508 --> 05:25:43,243
RECENTLY IN BRAZIL AND I TALKED

8854
05:25:43,243 --> 05:25:45,912
TO THORS ONTIC ONCOLOGIST AND

8855
05:25:45,912 --> 05:25:48,414
THEY'VE SEEN THERE'S A DECLINE

8856
05:25:48,414 --> 05:25:49,849
WHERE THERE'S STRICT TOBACCO

8857
05:25:49,849 --> 05:25:51,484
ENFORCEMENT SO I THINK THERE'S

8858
05:25:51,484 --> 05:25:52,752
PROBABLY AN IMPACT THERE.

8859
05:25:52,752 --> 05:25:59,058
NON THAT HOPEFUL NOTE WE'RE

8860
05:25:59,058 --> 05:26:01,027
GOING TO ASK FOR A MOTION TO

8861
05:26:01,027 --> 05:26:06,099
APPROVE NI WILL SECOND.

8862
05:26:06,099 --> 05:26:10,870
>> SECOND.

8863
05:26:10,870 --> 05:26:11,237
>> DISCUSSION?

8864
05:26:11,237 --> 05:26:13,973
>> NYEAH, I WANT TO POINT
OUT

8865
05:26:13,973 --> 05:26:15,308
THAT STUDY BY [INDISCERNIBLE]

8866
05:26:15,308 --> 05:26:17,377
GILL ESTIMATE THADON AND TRUE

8867
05:26:17,377 --> 05:26:22,482
AND IT'S SHOWING THAT EVIDENCE

8868
05:26:22,482 --> 05:26:25,485
SMOKING MARIJUANA HAS THE SAME

8869
05:26:25,485 --> 05:26:27,253
FOR SMOKE AND DRIVING CANCER BUT

8870
05:26:27,253 --> 05:26:29,055
THERE'S A LOT OF DATA SHOWING

8871
05:26:29,055 --> 05:26:30,690
THERE'S POTENTIAL FOR THAT TO

8872
05:26:30,690 --> 05:26:32,125
HAPPEN THASN'T BEEN TODAYED TO

8873
05:26:32,125 --> 05:26:33,760
THAT EXTENT YET, THAT'S THE

8874
05:26:33,760 --> 05:26:34,093
ISSUE.

8875
05:26:34,093 --> 05:26:35,528
IT'S STUDYING OF MARIJUANA AND

8876
05:26:35,528 --> 05:26:37,630
CANCER HAS NOT BEEN DONE TO THE

8877
05:26:37,630 --> 05:26:40,867
EXTENT THAT TOBACCO HAS BEEN BUT

8878
05:26:40,867 --> 05:26:44,337
IT'S THE SAME BASIC CHEMICALS,

8879
05:26:44,337 --> 05:26:46,072
CONSISTING OF OTHER CONCEPT OF

8880
05:26:46,072 --> 05:26:52,245
CANC BEER AND TOBACCO SMOKING

8881
05:26:52,245 --> 05:26:54,314
DOES TEND TO BE PRESENT.

8882
05:26:54,314 --> 05:26:55,381
>> EXPR JUST QUICKLY A
REMIND

8883
05:26:55,381 --> 05:26:57,250
THERAPY AND IS ACTUALLY STUDYING

8884
05:26:57,250 --> 05:27:00,019
THE IMPACT OF POLICY WHICH IS

8885
05:27:00,019 --> 05:27:01,221
VERY DIFFERENT FROM KIND OF

8886
05:27:01,221 --> 05:27:02,455
LOOKING AT CANCER OUTCOMES.

8887
05:27:02,455 --> 05:27:03,489
>> OKAY, WE NEED A VOTE.

8888
05:27:03,489 --> 05:27:07,560
ARE THERE ANY NAYS?

8889
05:27:07,560 --> 05:27:11,297
ARE THERE ANY ABSTENTIONS?

8890
05:27:11,297 --> 05:27:19,339
ONE ABSTENTION. 

8891
05:27:19,339 --> 05:27:22,775
OKAY, THE LAST 1 NO, NO, WE HAVE

8892
05:27:22,775 --> 05:27:24,844
THE RFAs, BUT WE'RE GOING TO

8893
05:27:24,844 --> 05:27:26,479
HAVE MODEL CITIZEN MEEK POND WHO

8894
05:27:26,479 --> 05:27:29,616
WILL PRESENT THE NCI, SBI, OUR

8895
05:27:29,616 --> 05:27:33,219
CONTRACTS WHICH IS DEFINITE FROM

8896
05:27:33,219 --> 05:27:34,621
THE OVERALL PROGRAM, AND WE HAVE

8897
05:27:34,621 --> 05:27:40,927
A COMMITTEE OF NELSON CEASARY,

8898
05:27:40,927 --> 05:27:43,129
RICH AND MYSELF, MOONIQUE TAKE

8899
05:27:43,129 --> 05:27:44,030
IT AWAY, PLEASE.

8900
05:27:44,030 --> 05:27:45,465
>> SO GOOD AFTERNOON I'M

8901
05:27:45,465 --> 05:27:48,134
MONIQUE, ON BEHALF OF THE NCI,

8902
05:27:48,134 --> 05:27:49,669
SBIR DEVELOPMENT CENTER, I WILL

8903
05:27:49,669 --> 05:27:52,538
PRESENT OUR CONTRACT TOPICS.

8904
05:27:52,538 --> 05:27:54,874
SO THE SBIR OFFICE SUPPORTS

8905
05:27:54,874 --> 05:27:55,842
INNOVATIVE TRANSLATIONAL

8906
05:27:55,842 --> 05:27:57,277
RESEARCH THAT'S CONDUCTED BY

8907
05:27:57,277 --> 05:27:57,944
SMALL BUSINESSES, LOCATED

8908
05:27:57,944 --> 05:28:03,416
THROUGHOUT THE U.S., AND THE

8909
05:28:03,416 --> 05:28:05,618
SBIR TTR PROGRAM IS CONGRESSALLY

8910
05:28:05,618 --> 05:28:07,053
MANDATED SET ASIDE SO FEDERAL

8911
05:28:07,053 --> 05:28:09,355
AGENCIES WITH R&D BUDGETS
THAT

8912
05:28:09,355 --> 05:28:13,159
EXCEED A CERTAIN SIZE ARE

8913
05:28:13,159 --> 05:28:14,460
REQUIRED TO ADMINISTER THESE

8914
05:28:14,460 --> 05:28:15,094
PROGRAMS.

8915
05:28:15,094 --> 05:28:16,562
HERE WE CAN UTILIZE THE GRANTS

8916
05:28:16,562 --> 05:28:19,098
AND CONTRACT MECHANISMS AND HERE

8917
05:28:19,098 --> 05:28:21,334
I'M SHOWING FROM FY2023, ABOUT

8918
05:28:21,334 --> 05:28:23,503
12% OF OUR BUDGET WENT TOWARDS

8919
05:28:23,503 --> 05:28:26,105
THE CONTRACT MECHANISM, VERSUS

8920
05:28:26,105 --> 05:28:28,574
ABOUT 88% THROUGH THE

8921
05:28:28,574 --> 05:28:29,676
INVESTIGATION INITIATED GRANTS.

8922
05:28:29,676 --> 05:28:30,977
SO THIS DOES FLUCTUATE THOUGH

8923
05:28:30,977 --> 05:28:36,916
FROM YEAR TO YEAR AND WE'VE GONE

8924
05:28:36,916 --> 05:28:39,886
ANYWHERE 25% ALMOST 30% FOR

8925
05:28:39,886 --> 05:28:40,219
CONTRACKS.

8926
05:28:40,219 --> 05:28:43,523
SO WITH THE CONTRACT MECHANISM,

8927
05:28:43,523 --> 05:28:46,192
WE CAN ISSUE VERY NARROWLY

8928
05:28:46,192 --> 05:28:47,794
FOCUSED TOPICS WITH SET

8929
05:28:47,794 --> 05:28:50,663
MILESTONES AND PRODUCT

8930
05:28:50,663 --> 05:28:53,266
DEVELOPMENT, DELIVERABLES THAT

8931
05:28:53,266 --> 05:28:54,934
NCI DEFINES, AND THEN WE LOOK AT

8932
05:28:54,934 --> 05:28:56,402
THE OVERALL SUCCESS RATES FOR A

8933
05:28:56,402 --> 05:28:57,704
NUMBER OF PROPOSALS THAT WE

8934
05:28:57,704 --> 05:29:00,073
AWARD, I DO WANT TO NOTE THAT

8935
05:29:00,073 --> 05:29:01,774
OUR CONTRACKS PROPOSALS ARE

8936
05:29:01,774 --> 05:29:04,210
QUITE COMPETITIVE AND

8937
05:29:04,210 --> 05:29:05,378
AROUND--I'M SORRY AROUND 15%

8938
05:29:05,378 --> 05:29:07,680
SUCCESS RATE FOR CONTRACTS, THIS

8939
05:29:07,680 --> 05:29:09,315
IS COMPARABLE TO OUR GRANDS

8940
05:29:09,315 --> 05:29:13,419
PORTFOLIO WHERE WE SEE SLIGHTLY

8941
05:29:13,419 --> 05:29:15,021
LOWER NUMBERS AROUND 8-10%

8942
05:29:15,021 --> 05:29:16,456
SUCCESS FOR OUR EARLY STAGE

8943
05:29:16,456 --> 05:29:18,124
PHASE 1 PROJECTS AND WE SEE

8944
05:29:18,124 --> 05:29:21,627
SLIGHTLY HIGHER SUCCESS WITH OUR

8945
05:29:21,627 --> 05:29:23,396
AGREANCE WITH OUR LATER STAGE 2

8946
05:29:23,396 --> 05:29:25,131
PROJECTS AND THEN I DID JUST

8947
05:29:25,131 --> 05:29:28,534
WANT TO KNOW THAT THIS IS NOT

8948
05:29:28,534 --> 05:29:30,770
AFFECT THE RPG POOL THIS, IS THE

8949
05:29:30,770 --> 05:29:31,938
CONGRESSALLY MANDATED SET ASIDE.

8950
05:29:31,938 --> 05:29:33,606
SO WE FUND BUSINESSES THROUGH

8951
05:29:33,606 --> 05:29:35,608
THE CONTRACT MECHANISM FOR

8952
05:29:35,608 --> 05:29:38,311
SEVERAL REASONS, 1 IS SOMETIMES

8953
05:29:38,311 --> 05:29:39,879
TO ADDRESS A NEED FROM THE

8954
05:29:39,879 --> 05:29:42,081
CANCER COMMUNITY BUT OFTEN IT'S

8955
05:29:42,081 --> 05:29:44,484
TO STIMULATE RESEARCH AND

8956
05:29:44,484 --> 05:29:45,551
PRODUCT DEVELOPMENT IN A CERTAIN

8957
05:29:45,551 --> 05:29:47,320
AREA SO THIS COULD BE A NEW

8958
05:29:47,320 --> 05:29:50,056
EMERGING AREA OR IT COULD BE

8959
05:29:50,056 --> 05:29:51,958
MEDICALLY CHALLENGING AREA,

8960
05:29:51,958 --> 05:29:54,460
SOMEWHERE WITH A HIGH OR

8961
05:29:54,460 --> 05:29:56,429
SIGNIFICANT UNMET MEDICAL NEED.

8962
05:29:56,429 --> 05:29:58,364
LASTLY WE ALSO USE THIS TO

8963
05:29:58,364 --> 05:29:59,632
ADDRESS CERTAIN PATIENT

8964
05:29:59,632 --> 05:30:01,834
POPULATIONS OR MAYBE CERTAIN

8965
05:30:01,834 --> 05:30:03,236
CANCER INDICATIONS THAT ARE

8966
05:30:03,236 --> 05:30:11,044
UNDERREPRESENTED IN OUR IMRANTS

8967
05:30:11,044 --> 05:30:11,310
PORTFOLIO.

8968
05:30:11,310 --> 05:30:13,012
SO BEFORE I PRESENT THE TOPICS,

8969
05:30:13,012 --> 05:30:15,481
I WANT TO GIVE A SHORT SUMMARY

8970
05:30:15,481 --> 05:30:18,351
TO GET THIS FOR THE PROGECS EACH

8971
05:30:18,351 --> 05:30:21,521
YEAR SO IN THE PAUL WE SOLICIT

8972
05:30:21,521 --> 05:30:28,227
TOPIC IDEAS FROM NCI DIVISIONS

8973
05:30:28,227 --> 05:30:28,494
 DIVISIONS

8974
05:30:28,494 --> 05:30:31,631
AND OFFICES AND CENTERS.

8975
05:30:31,631 --> 05:30:33,232
IN OF THE PATHWAY GIVES WE'VE

8976
05:30:33,232 --> 05:30:35,334
ALSO COLLABORATE WIDE FDA, TO

8977
05:30:35,334 --> 05:30:40,139
GET THEIR RECOMMENDATIONS AS

8978
05:30:40,139 --> 05:30:40,940
WELL.

8979
05:30:40,940 --> 05:30:43,409
SO FOR FY25 WE RECEIVED 15 TOPIC

8980
05:30:43,409 --> 05:30:44,577
SUBMISSIONS, EACH OF THESE

8981
05:30:44,577 --> 05:30:46,679
SUBMIG DUALAS, THE TOPIC AUTHORS

8982
05:30:46,679 --> 05:30:48,614
ARE REQUIRED TO DO A PORTFOLIO

8983
05:30:48,614 --> 05:30:50,149
ANALYSIS THAT DETAILS NOT ONLY

8984
05:30:50,149 --> 05:30:57,290
THE NCI FUNDING BUT ALSO THE NIH

8985
05:30:57,290 --> 05:30:59,559
FUNDING SBIR AND NONSBIR IN

8986
05:30:59,559 --> 05:31:00,026
THESE AREAS.

8987
05:31:00,026 --> 05:31:01,694
THESE THEN GO TO OUR TECHNOLOGY

8988
05:31:01,694 --> 05:31:03,596
ADVISORY GROUPS AND WE HAVE 2

8989
05:31:03,596 --> 05:31:07,433
GROUPS THAT ARE COMPOSED OF

8990
05:31:07,433 --> 05:31:09,836
SUBJEK MATTER EXPERTS ACROSS NCI

8991
05:31:09,836 --> 05:31:11,504
TO IN ADDITION TO OUR PROGRAM

8992
05:31:11,504 --> 05:31:22,014
DIRECTORS IN THE SBIR OFFICE.

8993
05:31:26,652 --> 05:31:28,521
FROM THERE SIGNIFICANT WORK IS

8994
05:31:28,521 --> 05:31:30,389
DONE ON THIS STAGE ACROSS NCI AS

8995
05:31:30,389 --> 05:31:32,425
WELL AS TAG REVOWERS PROVOIDING

8996
05:31:32,425 --> 05:31:40,366
FEEDBACK AND IMPROVE AMS TO THE

8997
05:31:40,366 --> 05:31:42,869
TOPICS AT THIS POINT.

8998
05:31:42,869 --> 05:31:45,771
SO BEFORE I BEIMIN THE TOPICS, I

8999
05:31:45,771 --> 05:31:47,874
HAVE 13 THIS YEAR THAT WE WILL

9000
05:31:47,874 --> 05:31:48,574
BE PRESENTING FOR CONSIDERATION,

9001
05:31:48,574 --> 05:31:51,277
ALL 13 HAVE BEEN APPROVED BY

9002
05:31:51,277 --> 05:31:56,149
SBL, AND I WILL BE SHOWING THEIR

9003
05:31:56,149 --> 05:31:57,416
TOPIC TITLE.

9004
05:31:57,416 --> 05:31:59,252
THE NCI DIVISION OFFICER THAT

9005
05:31:59,252 --> 05:32:00,653
CONTRIBUTED AND WROTE THE TOPIC

9006
05:32:00,653 --> 05:32:02,321
AS WELL AS OVERALL GOAL AND THE

9007
05:32:02,321 --> 05:32:03,689
NATIONAL CANCER PLAN THAT WE

9008
05:32:03,689 --> 05:32:07,426
FEEL THAT THE TOPIC SUPPORTS.

9009
05:32:07,426 --> 05:32:10,029
SO I'LL BEGIN THE 7 THERAPEUTICS

9010
05:32:10,029 --> 05:32:17,403
RELATED TOPICS FOR CONSIDERATION

9011
05:32:17,403 --> 05:32:18,538
WITH THE NOVEL CANCER VACCINES

9012
05:32:18,538 --> 05:32:22,575
WE HOPE IT SUPPORTS EARLY STAGE

9013
05:32:22,575 --> 05:32:23,276
VACCINE DEVELOPERS THAT WILL

9014
05:32:23,276 --> 05:32:26,179
LEAD TO SAFETY AND IMPROVED

9015
05:32:26,179 --> 05:32:30,049
EFFICACY OF RNA BASED CANCER

9016
05:32:30,049 --> 05:32:31,417
VACCINES AND HOPEFULLY OVERCOME

9017
05:32:31,417 --> 05:32:33,853
LIP I MUTATIONS OF THE LIPIT

9018
05:32:33,853 --> 05:32:35,354
NANO PARTICLE DIFFERY SYSTEM.

9019
05:32:35,354 --> 05:32:37,557
THE SECOND THERAPEUTIC TOPIC IS

9020
05:32:37,557 --> 05:32:38,858
THE DEVELOPMENT OF CANCER

9021
05:32:38,858 --> 05:32:41,394
PREVENTION AGENTS SO THERE'S

9022
05:32:41,394 --> 05:32:41,894
ACCUMULATING PRECLINICAL

9023
05:32:41,894 --> 05:32:43,229
EVIDENCE SUGGESTING THAT

9024
05:32:43,229 --> 05:32:45,097
VACCINES AND OTHER IMEULOGY

9025
05:32:45,097 --> 05:32:51,270
BASED INTERVENTIONS CAN INDUCE

9026
05:32:51,270 --> 05:32:52,672
HOST IMMUNE RESPONSES AND

9027
05:32:52,672 --> 05:32:53,839
PROVIDE EFFICACY, SO HERE THE

9028
05:32:53,839 --> 05:32:55,074
TYPE OF CANCER AND OPEN TO THE

9029
05:32:55,074 --> 05:32:58,277
OFFER WITH THE EXCEPTION OF

9030
05:32:58,277 --> 05:32:59,879
VIRUS INDUCED CANCERS WITH THE

9031
05:32:59,879 --> 05:33:01,047
LONG-TERM GOAL BEING TRANSLATION

9032
05:33:01,047 --> 05:33:09,021
OF EARLY WORK AND IMMUNO

9033
05:33:09,021 --> 05:33:09,855
PREVENTION SPACE.

9034
05:33:09,855 --> 05:33:14,927
THE INCOME TOPIC IS SYNTHETIC

9035
05:33:14,927 --> 05:33:15,962
MICROBES FOR IMMUNOLOGY

9036
05:33:15,962 --> 05:33:16,229
THERAPIES.

9037
05:33:16,229 --> 05:33:19,065
HERE THE GOAL TO DEVELOP MIKE

9038
05:33:19,065 --> 05:33:20,099
ROBIAL BASED THERAPY FOR

9039
05:33:20,099 --> 05:33:23,536
CLINICAL USE.

9040
05:33:23,536 --> 05:33:24,971
THE PROPOSED DEVELOPMENTMENTAL

9041
05:33:24,971 --> 05:33:26,339
AGING COULD BE PROPOSED AS

9042
05:33:26,339 --> 05:33:29,875
SINGLE AGENT OR IN COMBINATION

9043
05:33:29,875 --> 05:33:32,545
WITH EXISTING IMMUNE ONCOLOGY

9044
05:33:32,545 --> 05:33:34,413
TREATMENTS, HOWEVER, ANY ONCO

9045
05:33:34,413 --> 05:33:36,616
LYTIC VIRUSES OR NONSYNTHETTIC

9046
05:33:36,616 --> 05:33:37,316
MICROORGANISMS WOULD BE

9047
05:33:37,316 --> 05:33:41,721
CONSIDERED OUT OF SCOPE HERE

9048
05:33:41,721 --> 05:33:43,222
EMPLOY THE NEXT TOPIC WILL

9049
05:33:43,222 --> 05:33:45,524
SUPPORT THE DEVELOPMENT OF HPV

9050
05:33:45,524 --> 05:33:46,025
RELATED PRECANCKER.

9051
05:33:46,025 --> 05:33:48,728
SO WE KNOW THAT HPV RELATED

9052
05:33:48,728 --> 05:33:50,162
CANCERS AFFECT MILLIONS OF

9053
05:33:50,162 --> 05:33:52,698
PEOPLE WORLD WIDE AND THERE'S

9054
05:33:52,698 --> 05:33:54,934
ONGOING IMPORTANT EFFORTS FOR

9055
05:33:54,934 --> 05:33:56,135
SCREENING AND PROPHYLACTIC

9056
05:33:56,135 --> 05:33:57,737
APPROACHES BUT THIS TOPIC HERE

9057
05:33:57,737 --> 05:34:00,773
FOCUSES ON NEW TREATMENTS THAT

9058
05:34:00,773 --> 05:34:03,743
CAN EITHER PREVENT PROGRESSION

9059
05:34:03,743 --> 05:34:05,845
OF IDENTIFIED CHRONIC HPV

9060
05:34:05,845 --> 05:34:12,251
INFECTIONS OR INDUCE REGRESSION

9061
05:34:12,251 --> 05:34:13,085
OF PRECANCEROUS LESIONS.

9062
05:34:13,085 --> 05:34:15,388
THE NEXT TOPIC SUPPORTS

9063
05:34:15,388 --> 05:34:16,122
TRUCKS--THEN TRICIAN,

9064
05:34:16,122 --> 05:34:17,189
INTERVENTIONS FOR REDUCING

9065
05:34:17,189 --> 05:34:18,357
CANCER RELATED SYMPTOMS THAT WE

9066
05:34:18,357 --> 05:34:22,361
KNOW PEOPLE CAN EXPERIENCE WHEN

9067
05:34:22,361 --> 05:34:23,462
RECEIVING CANCER TREATMENT.

9068
05:34:23,462 --> 05:34:25,364
SO MILD NUTRITION CAN NOT ONLY

9069
05:34:25,364 --> 05:34:26,265
REDUCE A PATIENT'S QUALITY OF

9070
05:34:26,265 --> 05:34:29,635
LIFE BUT IT CAN ALSO LEAD TO

9071
05:34:29,635 --> 05:34:30,903
SUBOPTIMAL TREATMENT OUTCOMES SO

9072
05:34:30,903 --> 05:34:33,105
HERE'S EXAMPLE OF PRODUCTS THAT

9073
05:34:33,105 --> 05:34:34,607
CAN BE DEVELOPED, INCLUDE

9074
05:34:34,607 --> 05:34:38,911
NUTRITIONAL AGENTS OR MEDICAL

9075
05:34:38,911 --> 05:34:39,111
FOODS.

9076
05:34:39,111 --> 05:34:40,179
THE NEXT TOPIC CERTAINTIES

9077
05:34:40,179 --> 05:34:42,515
DEVELOPMENT OF DRUG LOADED CARE

9078
05:34:42,515 --> 05:34:45,017
YEAR PARTICLES FOR IMPROVED ORAL

9079
05:34:45,017 --> 05:34:46,986
THEREFOREY OF COLON CANCER

9080
05:34:46,986 --> 05:34:47,653
PREVENTION AGENTS.

9081
05:34:47,653 --> 05:34:49,955
HERE OFFERS SHOULD DEVELOP A

9082
05:34:49,955 --> 05:34:52,391
NOVEL DELIVERY SYSTEM, THAT

9083
05:34:52,391 --> 05:34:55,227
PROTECTS AN ORORRAL AGENT FROM

9084
05:34:55,227 --> 05:34:56,395
THE GASTROINTESTINAL ENVIRONMENT

9085
05:34:56,395 --> 05:34:58,798
AND LEADS TO ENHANCED HALF LIVE

9086
05:34:58,798 --> 05:35:00,099
AND ENVIRONMENT IN THE

9087
05:35:00,099 --> 05:35:00,566
COLORADOON.

9088
05:35:00,566 --> 05:35:02,335
THIS OPEN MEETINGIC'S OPEN TO

9089
05:35:02,335 --> 05:35:03,269
DIFFERENT CARRIER PARTICLES, BUT

9090
05:35:03,269 --> 05:35:04,904
THE NEW SYSTEM SHOULD DEMON

9091
05:35:04,904 --> 05:35:05,838
TRAIT THIS PROLONGED

9092
05:35:05,838 --> 05:35:07,640
CONCENTRATION IN THE COLON.

9093
05:35:07,640 --> 05:35:10,509
AS WELL AS HAVE VERY LIMITED

9094
05:35:10,509 --> 05:35:11,410
SYSTEM TEMMIC SIDE CENTER FOR

9095
05:35:11,410 --> 05:35:17,616
EXCELLENCE ON AGINGS.

9096
05:35:17,616 --> 05:35:19,385
THE LAST THERAPEUTICS TOPIC FOR

9097
05:35:19,385 --> 05:35:21,420
CONSIDERATION TODAY IS THE

9098
05:35:21,420 --> 05:35:26,492
DEVELOPMENT OF ANTIBODY DRUG

9099
05:35:26,492 --> 05:35:26,892
CONJUGATES.

9100
05:35:26,892 --> 05:35:29,161
AS RADIO DIAGNOSTICS FOR

9101
05:35:29,161 --> 05:35:30,496
TREATING CANCER MUCH THE GOAL IS

9102
05:35:30,496 --> 05:35:32,932
TO IMPROVE EFFICACY IN 2 WAYS,

9103
05:35:32,932 --> 05:35:36,736
THE FIRST IS TO ADD A

9104
05:35:36,736 --> 05:35:37,436
DINUCLEOTIDE CONJUGATE THAT

9105
05:35:37,436 --> 05:35:38,871
ALLOWS FOR WHOLE BODY IMAGING,

9106
05:35:38,871 --> 05:35:41,407
THE SECOND WAY IS TOEDAAD

9107
05:35:41,407 --> 05:35:42,341
THERAPEUTIC RADIO NUCLEOTIDE SO

9108
05:35:42,341 --> 05:35:45,244
THE END PRODUCT THAT WE'RE

9109
05:35:45,244 --> 05:35:47,747
LOOKING AT IS ADC THAT CAN

9110
05:35:47,747 --> 05:35:48,781
COUPLE DIAGNOSTIC CAPABILITIES

9111
05:35:48,781 --> 05:35:55,888
WITH BOTH CHEMICAL AND RADIATION

9112
05:35:55,888 --> 05:35:56,288
BASED TREATMENTS.

9113
05:35:56,288 --> 05:35:59,725
SMRKS SO THE NEXT 2 TOPICS FALL

9114
05:35:59,725 --> 05:36:01,627
UNDER CLINICAL DIAGNOSTICS AND

9115
05:36:01,627 --> 05:36:02,695
MOLECULAR ANALYSIS, I WILL BEGIN

9116
05:36:02,695 --> 05:36:05,097
WITH POINT OF CARE DETECTION

9117
05:36:05,097 --> 05:36:08,234
AGAINST ANTIBODIES OF HPV 16,

9118
05:36:08,234 --> 05:36:11,470
18, E6 AND 7 ONK O PROTEINS, SO

9119
05:36:11,470 --> 05:36:13,339
THE PRODUCT ENVISIONS HERE IS A

9120
05:36:13,339 --> 05:36:14,407
SIRROLOGY BASED RAPID TEST FOR

9121
05:36:14,407 --> 05:36:16,776
SCREENING AND EARLY DETECTION OF

9122
05:36:16,776 --> 05:36:18,310
HPV RELATED CANCERS THAT IS BOTH

9123
05:36:18,310 --> 05:36:19,812
AFFORDABLE AND CAN BE USED

9124
05:36:19,812 --> 05:36:21,781
OUTSIDE OF CLINICAL SETTING.

9125
05:36:21,781 --> 05:36:24,984
WE BELIEVE A PRODUCT LIKE THIS

9126
05:36:24,984 --> 05:36:26,819
COULD INCREASE ACCESS TO HPV

9127
05:36:26,819 --> 05:36:28,387
TESTING FOR HIGH RISK POP

9128
05:36:28,387 --> 05:36:29,555
EULOGIES INCLUDING PEOPLE LIVING

9129
05:36:29,555 --> 05:36:32,992
IN COUNTRIES WITH LIMITED

9130
05:36:32,992 --> 05:36:33,692
MEDICAL INFRASTRUCTURE.

9131
05:36:33,692 --> 05:36:35,561
THE NEXT TOPIC IS ANOTHER POINT

9132
05:36:35,561 --> 05:36:39,131
OF CARE TECHNOLOGY, FOCUSED HERE

9133
05:36:39,131 --> 05:36:39,832
ON GASTROINTESTINAL TRACK CANCER

9134
05:36:39,832 --> 05:36:41,467
FOR PREVENTION AND EARLY

9135
05:36:41,467 --> 05:36:41,734
DETECTION.

9136
05:36:41,734 --> 05:36:43,636
WHILE SOME PROGRESS HAS BEEN

9137
05:36:43,636 --> 05:36:46,172
MADE WITH GI CANCERS WE KNOW

9138
05:36:46,172 --> 05:36:48,207
DISPARITIES AND DISEASE BURDEN

9139
05:36:48,207 --> 05:36:50,276
AND MORTALITY EXISTS FOR SOME

9140
05:36:50,276 --> 05:36:51,744
MINORITY COMMUNITIES AS WELL AS

9141
05:36:51,744 --> 05:36:52,711
RURAL POPULATIONS.

9142
05:36:52,711 --> 05:36:54,313
SO THE END PRODUCT DEVELOPED

9143
05:36:54,313 --> 05:36:55,414
HERE SHOULD BE BOTH COST EFFECT

9144
05:36:55,414 --> 05:36:58,250
AND I HAVE HAVE HIGH SENSITIVITY

9145
05:36:58,250 --> 05:37:06,158
AND SPECIFICITY WHICH WILL

9146
05:37:06,158 --> 05:37:09,094
HOPEFULLY HELP REDUCE THESE

9147
05:37:09,094 --> 05:37:09,895
BARRIERS TO TESTING.

9148
05:37:09,895 --> 05:37:11,163
NEXT WE HAVE 2 INFORMATION

9149
05:37:11,163 --> 05:37:13,466
TECHNOLOGY AND DIGIT AT HEALTH

9150
05:37:13,466 --> 05:37:14,166
TOPICS FOR CONSIDERATION THE

9151
05:37:14,166 --> 05:37:18,204
FIRST TOPIC IS THE DEVELOPMENT

9152
05:37:18,204 --> 05:37:19,405
OF DIGITAL BIOMARKERS FOR

9153
05:37:19,405 --> 05:37:20,005
CLINICAL CANCER CARE.

9154
05:37:20,005 --> 05:37:22,274
SO THERE'S A RANGE OF DIGITAL

9155
05:37:22,274 --> 05:37:24,577
HEALTH TECHNOLOGIES THAT CAN

9156
05:37:24,577 --> 05:37:25,544
MONITOR AND COLLECT PATIENT

9157
05:37:25,544 --> 05:37:26,512
INFORMATION IN REALTIME, AND THE

9158
05:37:26,512 --> 05:37:29,014
IDEA HERE IS TO INCORPORATE THIS

9159
05:37:29,014 --> 05:37:30,783
INFORMATION, INTO A DIGITAL

9160
05:37:30,783 --> 05:37:32,651
BIOMARKER THAT CAN SERVE AS A

9161
05:37:32,651 --> 05:37:34,987
REMOTE INDICATOR OF CERTAIN

9162
05:37:34,987 --> 05:37:38,591
BIOLOGICAL OR PATHOGENIC

9163
05:37:38,591 --> 05:37:39,058
PROCESS.

9164
05:37:39,058 --> 05:37:41,927
THE NEXT TOPIC IS DIGITAL TWIN

9165
05:37:41,927 --> 05:37:43,362
SOFTWARE FOR OPTIMIZATION OF

9166
05:37:43,362 --> 05:37:44,530
CANCER RADIATION THERAPY EMPLOY

9167
05:37:44,530 --> 05:37:46,198
SO A DINLITTAL TWIN IS A VIRTUAL

9168
05:37:46,198 --> 05:37:47,700
MODEL SYSTEM CAN BE USE INDEED A

9169
05:37:47,700 --> 05:37:50,135
WIDE VARIETY OF WAYS BUT HERE,

9170
05:37:50,135 --> 05:37:53,339
FOR EXAMPLE, IN THE CONTEXT OF

9171
05:37:53,339 --> 05:37:55,908
RADIATION THERAPY, WE ENVISION

9172
05:37:55,908 --> 05:37:57,543
DIGITAL TWIN OF THE PATIENT USED

9173
05:37:57,543 --> 05:37:59,245
BY A PROVIDER TO ARK ASSESSES

9174
05:37:59,245 --> 05:38:01,380
AVAILABLE THERAPIES AS WELL AS

9175
05:38:01,380 --> 05:38:02,915
POETIC TEBTIAL COMBINATIONS OF

9176
05:38:02,915 --> 05:38:05,784
THERAPY, AND HELP GUIDE THEIR

9177
05:38:05,784 --> 05:38:07,319
CLINICAL DECISION MAKING PROCESS

9178
05:38:07,319 --> 05:38:08,053
AND PROVIDE INDIVIDUALIZED

9179
05:38:08,053 --> 05:38:14,960
TREATMENT FOR THEIR PATIENT.

9180
05:38:14,960 --> 05:38:16,462
NOW I'LL MOVE ON TO MEDICAL

9181
05:38:16,462 --> 05:38:19,465
DEVICES AND WE HAVE 1 TOPIC

9182
05:38:19,465 --> 05:38:22,001
TODAY, ENTITLED WEARABLE

9183
05:38:22,001 --> 05:38:23,068
TECHNOLOGIES TO FACILITATE

9184
05:38:23,068 --> 05:38:24,937
REMOTE MONITORING OF CANCER

9185
05:38:24,937 --> 05:38:25,538
PATIENTS FOLLOWING TREATMENT.

9186
05:38:25,538 --> 05:38:28,240
THE IDEA HERE IS TO BUILD UPON

9187
05:38:28,240 --> 05:38:29,441
CURRENT WEARABLE DEVICE

9188
05:38:29,441 --> 05:38:30,609
CAPABILITIES TO PROVIDE

9189
05:38:30,609 --> 05:38:31,510
CLINICALLY RELEVANT INFORMATION

9190
05:38:31,510 --> 05:38:41,954
TO A PATIENT'S CARE TEAM.

9191
05:38:47,059 --> 05:38:49,495
SO THE LAST TOPIC FOR

9192
05:38:49,495 --> 05:38:51,030
CONSIDERATION TODAY FALLS UNDER

9193
05:38:51,030 --> 05:38:52,565
OUR RESEARCH TOOLS CATEGORY AND

9194
05:38:52,565 --> 05:38:53,866
IT'S ENTITLED ADVANCED MATERIALS

9195
05:38:53,866 --> 05:38:57,836
TO IMPROVE CANCER MODELING, FOR

9196
05:38:57,836 --> 05:38:58,304
RESEARCH.

9197
05:38:58,304 --> 05:39:00,272
SO HERE INITIALLY THE PRODUCTS

9198
05:39:00,272 --> 05:39:02,141
THAT ARE ENVISIONED WOULD BE

9199
05:39:02,141 --> 05:39:03,309
BIOMATERIAL BASED TOOLS THAT CAN

9200
05:39:03,309 --> 05:39:07,613
BE USED FOR BASIC AND

9201
05:39:07,613 --> 05:39:08,547
PRECLINICAL CANCER RESEARCHERS

9202
05:39:08,547 --> 05:39:10,382
BUT LONGER TERM GOAL WOULD BE TO

9203
05:39:10,382 --> 05:39:12,785
PROVIDE THE CLINICAL RESEARCH

9204
05:39:12,785 --> 05:39:14,420
COMMUNITY WITH IMPROVED INVITRO

9205
05:39:14,420 --> 05:39:16,589
MODELS THAT COULD COMPLEMENT OR

9206
05:39:16,589 --> 05:39:25,397
POTENTIALLY REPLACE IN VIVO

9207
05:39:25,397 --> 05:39:25,664
MODELS.

9208
05:39:25,664 --> 05:39:26,799
SOPHISTICATED LASTLY TODAY, I

9209
05:39:26,799 --> 05:39:30,436
WANT TO END BY HEIGHT LIGHTING

9210
05:39:30,436 --> 05:39:33,105
THAT THE SBIR CONTRACT MECHANISM

9211
05:39:33,105 --> 05:39:35,674
HAS SUPPORTED MANY SUCCESSFUL

9212
05:39:35,674 --> 05:39:36,408
COMMERCIALIZATION, SUCCESSFUL

9213
05:39:36,408 --> 05:39:37,910
COMMERCIALIZATION OF PRODUCTS

9214
05:39:37,910 --> 05:39:41,413
AND REALLY ACROSS THE SPACE

9215
05:39:41,413 --> 05:39:42,381
DIAGNOSING MONITORING, TREATING

9216
05:39:42,381 --> 05:39:49,021
PATIENTS WITH CANCER, HERE I'M

9217
05:39:49,021 --> 05:39:51,123
HIGHLIGHTING CIVATECH AND IT'S A

9218
05:39:51,123 --> 05:39:55,160
PRODUCT USED TO TREAT TUMORS

9219
05:39:55,160 --> 05:39:56,161
ORIGINALLY SUPPORTED BY CONTRACT

9220
05:39:56,161 --> 05:39:59,965
XTHEY WENT TO TO HAVE 2 FOLLOW

9221
05:39:59,965 --> 05:40:03,569
ON PRODUCTS TO CIVASTRING AND

9222
05:40:03,569 --> 05:40:04,603
CIERK VADERM AS WELL.

9223
05:40:04,603 --> 05:40:06,572
AND THESE ARE USED THROUGHOUT

9224
05:40:06,572 --> 05:40:06,905
THE COUNTRY.

9225
05:40:06,905 --> 05:40:09,274
MOSTLY I WANT TO CONCLUDE WE DID

9226
05:40:09,274 --> 05:40:10,943
AN ANALYSIS OF THE CONTRACTS

9227
05:40:10,943 --> 05:40:12,878
PORTFOLIO AS A WHOLE AND WE

9228
05:40:12,878 --> 05:40:14,513
FOUND 30 PSYCHOFIZZISTS OF

9229
05:40:14,513 --> 05:40:17,149
CONTRACTS DO RESULT IN

9230
05:40:17,149 --> 05:40:20,152
COMMERCIALIZED  PRODUCTS FOR

9231
05:40:20,152 --> 05:40:22,454
PATIENTS AND THAT WAS SIMILAR

9232
05:40:22,454 --> 05:40:23,989
FOR OUR GRANTS PORTFOLIO AS

9233
05:40:23,989 --> 05:40:24,189
WELL.

9234
05:40:24,189 --> 05:40:25,290
SO WE CONSIDER THE CONTRACKS TO

9235
05:40:25,290 --> 05:40:28,260
BE AN IMPORTANT MECHANISM WE CAN

9236
05:40:28,260 --> 05:40:31,597
USE TO FUND INNOVATIVE PRODUCTS

9237
05:40:31,597 --> 05:40:34,199
FOR PATIENTS AND INSURE THAT WE

9238
05:40:34,199 --> 05:40:38,671
ARE REACHING EVERYONE ACROSS THE

9239
05:40:38,671 --> 05:40:39,238
COUNTRY SO THANKS.

9240
05:40:39,238 --> 05:40:40,105
HAPPY TO ANSWER ANY QUESTIONS

9241
05:40:40,105 --> 05:40:43,208
AND I DO WANT TO NOTE THANKS TO

9242
05:40:43,208 --> 05:40:44,677
THE BSA SUBCOMMITTEE FOR REALLY

9243
05:40:44,677 --> 05:40:44,943
REVIEWING.

9244
05:40:44,943 --> 05:40:47,346
IT WAS A LOT OF TOPICS TO REVIEW

9245
05:40:47,346 --> 05:40:53,552
AND REALLY APPRECIATE ALL YOUR

9246
05:40:53,552 --> 05:40:56,655
FEEDBACK AND COMMENTS.

9247
05:40:56,655 --> 05:41:05,931
>> NELLY WANT TO START? 

9248
05:41:05,931 --> 05:41:06,965
>> RICH, YOU GO FIRST.

9249
05:41:06,965 --> 05:41:08,834
>> ALL RIGHT, THANK YOU
DR. POND

9250
05:41:08,834 --> 05:41:10,569
FOR YOUR EXCELLENT PRESENTATION,

9251
05:41:10,569 --> 05:41:12,604
MY FELLOW REVIEWERS AND SHELLY

9252
05:41:12,604 --> 05:41:14,573
AND NELLY AND I WERE SUPPORTIVE

9253
05:41:14,573 --> 05:41:19,445
OF THE 13 SBIR PROPOSALS.

9254
05:41:19,445 --> 05:41:20,245
ESPECIALLY WANTED TO COMEBD YOU

9255
05:41:20,245 --> 05:41:23,549
ON THE EMPHASIS ON CANCER

9256
05:41:23,549 --> 05:41:23,882
PREVENTION.

9257
05:41:23,882 --> 05:41:25,984
OUR QUESTIONS FOR THE GROUP

9258
05:41:25,984 --> 05:41:28,187
MAINLY WERE LESS ABOUT THE

9259
05:41:28,187 --> 05:41:29,021
INDIVIDUAL PROPOSALS BUT MORE

9260
05:41:29,021 --> 05:41:32,858
ABOUT THE PROCESS AND DR. POND

9261
05:41:32,858 --> 05:41:33,826
NICELY DRIEBED THE PROCESS FOR

9262
05:41:33,826 --> 05:41:35,160
YOU.

9263
05:41:35,160 --> 05:41:37,262
SO WITH THAT, AND KNOWING THAT

9264
05:41:37,262 --> 05:41:38,330
WE ARE SUPPORTIVE, I WILL TURN

9265
05:41:38,330 --> 05:41:44,036
IT OVER TO MY FELLOW REVIEWERS

9266
05:41:44,036 --> 05:41:44,369
FOR COMMENTS?

9267
05:41:44,369 --> 05:41:46,271
NELSON CEASARY?

9268
05:41:46,271 --> 05:41:48,273
>> ALL RIGHT, SMALL
TECHNICAL

9269
05:41:48,273 --> 05:41:49,174
DIFFICULTIES, AS WE TALK ABOUT

9270
05:41:49,174 --> 05:41:50,175
THIS, I JUST WANT TO SAY THIS

9271
05:41:50,175 --> 05:41:51,710
WAS A PLEASURE TO REVIEW.

9272
05:41:51,710 --> 05:41:54,213
I THINK WE HAD A LOT OF GREAT

9273
05:41:54,213 --> 05:41:57,816
QUESTIONS, AND WE UNDERSTAND

9274
05:41:57,816 --> 05:42:01,019
THAT THERE IS LIKE STILL THE

9275
05:42:01,019 --> 05:42:02,321
OPPORTUNITY PROPROPOSE FOR ABOUT

9276
05:42:02,321 --> 05:42:05,991
80% OF THE SBIR FUNDS, OPEN,

9277
05:42:05,991 --> 05:42:07,960
OPEN IDEAS BUT AT THE SAME TIME

9278
05:42:07,960 --> 05:42:10,496
THE TEAM HAS COME TOGETHER TO

9279
05:42:10,496 --> 05:42:12,264
SUGGIEST REALLY IMPACTFUL NEW

9280
05:42:12,264 --> 05:42:13,966
AREAS AND I'M PARTICULARLY

9281
05:42:13,966 --> 05:42:15,501
EXCITED ABOUT A LOT OF THEM IN

9282
05:42:15,501 --> 05:42:17,002
THE SPACE OF CANCER PREVENTION,

9283
05:42:17,002 --> 05:42:18,704
I THINK IS VERY THOUGHTFUL AND

9284
05:42:18,704 --> 05:42:20,606
OF COURSE AI.

9285
05:42:20,606 --> 05:42:21,874
SO, THANK YOU.

9286
05:42:21,874 --> 05:42:23,942
I THINK THIS WAS A VERY WORTH

9287
05:42:23,942 --> 05:42:25,377
WHILE AND THOUGHTFUL PROCESS,

9288
05:42:25,377 --> 05:42:29,982
AND I'M VERY SUPPORTIVE OF IT.

9289
05:42:29,982 --> 05:42:32,151
>> IT WAS VERY ENJOYABLE
AND WE

9290
05:42:32,151 --> 05:42:34,219
ASK ABOUT YOU KNOW EXTERNAL

9291
05:42:34,219 --> 05:42:36,321
INPUT AND I THINK THAT THERE IS

9292
05:42:36,321 --> 05:42:37,289
EXTERNAL INPUT THROUGH A NUMBER

9293
05:42:37,289 --> 05:42:40,192
OF WAYS TO THE SBIR PROGRAM BUT

9294
05:42:40,192 --> 05:42:42,161
ALSO THE REVIEW IS DONE BY AN

9295
05:42:42,161 --> 05:42:44,730
EXTERNAL GROUP SO I THINK WELL'S

9296
05:42:44,730 --> 05:42:45,697
PLENTY OF OPPORTUNITIES, VERY

9297
05:42:45,697 --> 05:42:55,474
INTERESTING SET OF CONTRACTS.

9298
05:42:55,474 --> 05:42:55,841
DISCUSSION?

9299
05:42:55,841 --> 05:42:56,642
NTHAIRNG YOU FOR THE

9300
05:42:56,642 --> 05:42:59,545
PRESENTATION AND THESE ARE ALL

9301
05:42:59,545 --> 05:43:00,479
TERRIFIC PROPOSALS AND I THINK

9302
05:43:00,479 --> 05:43:05,017
IT'S NICE TO SEE THAT AT LEAST

9303
05:43:05,017 --> 05:43:06,718
ONE-THIRD OF THESE EVENTUALLY GO

9304
05:43:06,718 --> 05:43:07,319
TO COMMERCIALIZATION.

9305
05:43:07,319 --> 05:43:14,560
WHAT I WAS GOING TO ASK IS AS A

9306
05:43:14,560 --> 05:43:16,061
SURGEON EVEN IN THE BACK UP

9307
05:43:16,061 --> 05:43:24,469
SLIDES SHOWS THAT LESS THAN 5%

9308
05:43:24,469 --> 05:43:26,405
GO TOWARDS SURGICAL TECHNOLOGY

9309
05:43:26,405 --> 05:43:30,342
AND COVID VOICE, 4 MONTHS AGO.

9310
05:43:30,342 --> 05:43:33,245
NNO WORRIES.

9311
05:43:33,245 --> 05:43:35,414
>> THE REASON I'M ASKING
IS WHEN

9312
05:43:35,414 --> 05:43:37,382
SURGEONS IN THE WAY, THEY WANT

9313
05:43:37,382 --> 05:43:39,618
LOW COST TOOLS AND IT'S HARD TO

9314
05:43:39,618 --> 05:43:42,921
GET SBIR FOR A SURGICAL TOOL SO

9315
05:43:42,921 --> 05:43:44,790
MOST OF THE THEM GRAVITATE

9316
05:43:44,790 --> 05:43:46,058
TOWARDS INDUSTRY AND THOSE DON'T

9317
05:43:46,058 --> 05:43:52,865
TEND TO BE CHEAP.

9318
05:43:52,865 --> 05:43:54,833
SO 1 SUGJOAOF THION I MIGHT MAKE

9319
05:43:54,833 --> 05:43:56,034
IS LOOK OUT FOR SURGICAL TOOLS

9320
05:43:56,034 --> 05:43:58,370
THAT ARE OUT THERE AND FUNDED.

9321
05:43:58,370 --> 05:44:04,009
>> OKAY, YEAH, GREAT
SUGGESTION.

9322
05:44:04,009 --> 05:44:05,878
YES ISSUES THE SLIDE YOU'RE

9323
05:44:05,878 --> 05:44:08,313
REFERRING TO IS FROM 1 YEAR, WE

9324
05:44:08,313 --> 05:44:10,249
DON'T DICTATE WHAT PERCENTAGE OF

9325
05:44:10,249 --> 05:44:12,351
FUNDING GOES TOWARD THERAPEUTIC,

9326
05:44:12,351 --> 05:44:13,652
SURGICAL TOOLS, ET CETERA IT'S

9327
05:44:13,652 --> 05:44:14,953
DETERMINED BY THE INNOVATIVE

9328
05:44:14,953 --> 05:44:16,521
IDEAS AND THE TOP SCORING

9329
05:44:16,521 --> 05:44:18,590
INNOVATIVE IDEAS THAT COME FROM

9330
05:44:18,590 --> 05:44:20,225
THE EXTERNAL COMMUNITY AND

9331
05:44:20,225 --> 05:44:22,461
INVESTIGATORS SO, BUT 1 WAY THAT

9332
05:44:22,461 --> 05:44:24,563
WE CAN TRY TO BOLSTER CERTAIN

9333
05:44:24,563 --> 05:44:27,099
AREAS IS THROUGH A CONTRACT

9334
05:44:27,099 --> 05:44:27,299
TOPIC.

9335
05:44:27,299 --> 05:44:28,867
WE DO HAVE METRICS THAT SHOW

9336
05:44:28,867 --> 05:44:31,570
THAT IF WE ISSUE A CONTRACT

9337
05:44:31,570 --> 05:44:32,938
TOPPER FOR 1 YEAR, WE HAVE

9338
05:44:32,938 --> 05:44:34,172
SEVERAL EXAMPLES WHERE THE NEXT

9339
05:44:34,172 --> 05:44:35,540
4 TO 5 YEARS WILL ACTUALLY

9340
05:44:35,540 --> 05:44:37,476
DOUBLE THE MEMBER OF

9341
05:44:37,476 --> 05:44:40,112
APPLICATIONS WE GET THROUGH OUR

9342
05:44:40,112 --> 05:44:42,447
GRANT MECHANISMS, SO, YEAH, THAT

9343
05:44:42,447 --> 05:44:43,682
WOULD BE--THAT'S AN EXCELLENT

9344
05:44:43,682 --> 05:44:45,117
SUGGESTION FOR A FUTURE TOPIC WE

9345
05:44:45,117 --> 05:44:45,684
CAN CONSIDER.

9346
05:44:45,684 --> 05:44:50,122
>> AND THE REASON BEING,
YOU

9347
05:44:50,122 --> 05:44:51,089
KNOW, EVERY YOU KNOW

9348
05:44:51,089 --> 05:44:52,791
[INDISCERNIBLE] HAS A VALUE OF

9349
05:44:52,791 --> 05:44:55,193
DEBT AND MOST SURMICAL TOOL FIST

9350
05:44:55,193 --> 05:44:57,029
THEY DON'T GET THIS OR INDUSTRY

9351
05:44:57,029 --> 05:45:02,467
SUPPORT THEY END UP DYING THERE.

9352
05:45:02,467 --> 05:45:03,368
>> THAICHG YOU.

9353
05:45:03,368 --> 05:45:05,003
NANY OTHER POINTS OF DISCUSSION

9354
05:45:05,003 --> 05:45:07,539
NTHIS MAY BE A NAIVE QUESTION SO

9355
05:45:07,539 --> 05:45:09,975
I'M LOOKING AT ADCs, I WASN'T

9356
05:45:09,975 --> 05:45:12,544
WHAT MY IMPRESSION THAT ADCs

9357
05:45:12,544 --> 05:45:14,913
WERE NOT INTERPRET WELL FROM A

9358
05:45:14,913 --> 05:45:17,516
CLINICAL APPLICATION SUCCESS  

9359
05:45:17,516 --> 05:45:20,552
PERSPECKIVE, IS THE IDEA OF THE

9360
05:45:20,552 --> 05:45:24,356
SBIR FOR ADCs TO SEE IF THIS

9361
05:45:24,356 --> 05:45:24,990
IMPROVES THEIR [INDISCERNIBLE].

9362
05:45:24,990 --> 05:45:29,061
SOMEONE ON THE PANEL CAN--WHAT

9363
05:45:29,061 --> 05:45:31,430
DOES THE SBIR DO FOR ADCs IN

9364
05:45:31,430 --> 05:45:31,630
THESE?

9365
05:45:31,630 --> 05:45:34,933
>> SO THIS IS A CONTRACT
AND

9366
05:45:34,933 --> 05:45:35,367
IT'S VERY SPECIFIC.

9367
05:45:35,367 --> 05:45:36,969
YOU WANT TO COMMENT ON THAT.

9368
05:45:36,969 --> 05:45:37,336
>> SURE, SURE.

9369
05:45:37,336 --> 05:45:40,238
SO I THINK THE CONTRACT OFFERS

9370
05:45:40,238 --> 05:45:41,974
THE WHYED IS THAT IT WOULD

9371
05:45:41,974 --> 05:45:44,076
COMBINE IMAGING AS WELL AS

9372
05:45:44,076 --> 05:45:46,078
RADIATION THERAPY ALONG WITH THE

9373
05:45:46,078 --> 05:45:47,646
CURRENT CYTOTOXIC AGENT THAT YOU

9374
05:45:47,646 --> 05:45:49,548
NOTED HAS HAD MIXED RESULTS IN

9375
05:45:49,548 --> 05:45:53,085
CLINIC AND SO HOPEFULLY, THAT,

9376
05:45:53,085 --> 05:45:54,820
YOU KNOW THAT KNOWLEDGE DOESN'T

9377
05:45:54,820 --> 05:45:55,821
EXIST AND HOPEFULLY INMODEL

9378
05:45:55,821 --> 05:46:06,331
CITIZENIVATING IN THOSE 2 WAYS

9379
05:46:08,533 --> 05:46:08,800
WOULD IMPROVE.

9380
05:46:08,800 --> 05:46:09,267
>> [INDISCERNIBLE].

9381
05:46:09,267 --> 05:46:12,704
OKAY, CAN WE HAVE A MOTION

9382
05:46:12,704 --> 05:46:13,038
DISCUSSION?

9383
05:46:13,038 --> 05:46:17,409
MOTION TO APPROVE?

9384
05:46:17,409 --> 05:46:20,445
NMOTION TO APPROVE NSECOND.

9385
05:46:20,445 --> 05:46:30,789
>> ANY DISCUSSION?

9386
05:46:32,457 --> 05:46:33,925
YES IN NETWORK OKAY, WE NEED TO

9387
05:46:33,925 --> 05:46:35,360
BE QUICK, WE HAVE 1 MORE.

9388
05:46:35,360 --> 05:46:39,398
>> WELL I JUST WANT TO
KNOW IS

9389
05:46:39,398 --> 05:46:41,433
IT THE PRESENTATIONS GIVEN,OOSE

9390
05:46:41,433 --> 05:46:43,201
NOT REALLY CLEAR WHAT IMPACT HAS

9391
05:46:43,201 --> 05:46:47,472
BEEN IN TERMS OF NUMBER OF

9392
05:46:47,472 --> 05:46:49,207
ACTUAL PATIENTS HAVING BEEN

9393
05:46:49,207 --> 05:46:50,976
TREATED WITH THE PRODUCT, WHAT

9394
05:46:50,976 --> 05:46:55,480
STATES IT'S USED IN ET CETERA.

9395
05:46:55,480 --> 05:47:00,118
IS THAT SOMETHING THAT COULD BE

9396
05:47:00,118 --> 05:47:00,952
PULLED TOGETHER AND PRESENTED SO

9397
05:47:00,952 --> 05:47:04,489
THAT WE HAVE A BETTER, REAL

9398
05:47:04,489 --> 05:47:08,760
IMPACT ON COMMUNITY AND HOW THE

9399
05:47:08,760 --> 05:47:09,661
COMMUNITY THROUGHOUT THE UNITED

9400
05:47:09,661 --> 05:47:12,230
STATES BOTH THE SCRIBERS AND THE

9401
05:47:12,230 --> 05:47:15,400
PATIENTS, THOSE KINDS OF DETAILS

9402
05:47:15,400 --> 05:47:16,935
USUALLY IN THE 5-10 K, THE

9403
05:47:16,935 --> 05:47:19,171
COMPANY WILL OFTEN HAVE THAT AS

9404
05:47:19,171 --> 05:47:19,838
PUBLIC INFORMATION ANYWAY.

9405
05:47:19,838 --> 05:47:21,473
>> I THINK WE CAN ASK FOR
THAT

9406
05:47:21,473 --> 05:47:22,641
FOR NEXT YEAR NSURE.

9407
05:47:22,641 --> 05:47:24,176
>> IF I COULD JUST
COMMENT, WE

9408
05:47:24,176 --> 05:47:25,610
HAVE DONE THAT ANALYSIS FOR THE

9409
05:47:25,610 --> 05:47:28,480
PAST 3 YEARS, TRYING TO MEASURE

9410
05:47:28,480 --> 05:47:30,082
PATIENT IMPACT, EXACTLY AS YOU

9411
05:47:30,082 --> 05:47:33,351
MENTIONED AND WE HAVE FOUND THAT

9412
05:47:33,351 --> 05:47:35,153
WE HAD 36 REGULATORY APPROVALS

9413
05:47:35,153 --> 05:47:37,856
THAT HAVE COME FROM TECHNOLOGIES

9414
05:47:37,856 --> 05:47:39,257
THAT RECEIVED SBIR FUNDING WITH

9415
05:47:39,257 --> 05:47:42,594
OVER 2/3RDS OF THESE APPROVALS

9416
05:47:42,594 --> 05:47:44,029
BEING FDA APPROVALS SO FROM THAT

9417
05:47:44,029 --> 05:47:46,198
MEASURE, WE FEEL THAT THAT IS 1

9418
05:47:46,198 --> 05:47:47,599
WAY TO MEASURE THESE

9419
05:47:47,599 --> 05:47:51,002
TECHNOLOGIES ARE REACHING

9420
05:47:51,002 --> 05:47:51,269
PATIENTS.

9421
05:47:51,269 --> 05:47:53,405
>> WE NEED TO HAVE A VOTE
NOW NI

9422
05:47:53,405 --> 05:47:56,575
DON'T QUITE UNDERSTAND THAT

9423
05:47:56,575 --> 05:47:57,542
BECAUSE THINGS ARE OFTEN

9424
05:47:57,542 --> 05:47:59,377
APPROVED AND YOU NEVER GET TO

9425
05:47:59,377 --> 05:48:00,345
PATIENTS THEY GET SOLD OFF,

9426
05:48:00,345 --> 05:48:02,914
THERE'S A LOT OF THINGS THAT

9427
05:48:02,914 --> 05:48:03,615
HAPPEN TO APPROVED PRODUCTS.

9428
05:48:03,615 --> 05:48:06,384
>> WE NEED TO VOTE NOKAY,
ARE

9429
05:48:06,384 --> 05:48:12,924
THERE ANY NAYS ON THE SBIR

9430
05:48:12,924 --> 05:48:17,929
CONTRACK? 

9431
05:48:17,929 --> 05:48:19,197
>> ANY ABSTENTIONS.

9432
05:48:19,197 --> 05:48:20,499
ONE ABSTENTION.

9433
05:48:20,499 --> 05:48:21,867
IT'S UNANIMOUS FROM THE BSA.

9434
05:48:21,867 --> 05:48:26,705
GOOD AND NOW WE HAVE

9435
05:48:26,705 --> 05:48:27,639
[INDISCERNIBLE] PRESENTING ABOUT

9436
05:48:27,639 --> 05:48:38,150
THE COME BIENED RFA REISSUES?

9437
05:48:39,117 --> 05:48:40,585
NTHANK YOU FOR THE TIEBT TO

9438
05:48:40,585 --> 05:48:42,854
PRESENT THE PROGRAM

9439
05:48:42,854 --> 05:48:44,389
ANNOUNCEMENTS WITH SPECIAL

9440
05:48:44,389 --> 05:48:46,024
RECEIPT OF REVIEW FROM ALL THE

9441
05:48:46,024 --> 05:48:56,568
DEVISION OFFICERS AND CENTERS OF

9442
05:49:33,538 --> 05:49:33,705
NCI.

9443
05:49:33,705 --> 05:49:39,144
>> CAN YOU MOVE THE SLIDE

9444
05:49:39,144 --> 05:49:40,679
PLEASE, I WILL CALL IT FUNDING

9445
05:49:40,679 --> 05:49:41,746
OPPORTUNITIES FOR THIS TALK AND

9446
05:49:41,746 --> 05:49:43,582
I WILL PRESENT EVERYTHING IN 2

9447
05:49:43,582 --> 05:49:53,992
SLIDES, SO BEAR WITH ME.

9448
05:49:56,828 --> 05:50:01,299
CAN YOU GO TO THE NEXT SLIDE,

9449
05:50:01,299 --> 05:50:01,533
PLEASE.

9450
05:50:01,533 --> 05:50:10,475
OR SHOW ME HOW TO DO IT.

9451
05:50:10,475 --> 05:50:13,845
>> OKAY, WONDERFUL THANK
YOU.

9452
05:50:13,845 --> 05:50:16,881
SO FROM LEFT TO RIGHT, WE ARE

9453
05:50:16,881 --> 05:50:19,017
STARTING WITH THE FIRST COLUMN

9454
05:50:19,017 --> 05:50:22,020
BEING THE DIVISION OFFICER

9455
05:50:22,020 --> 05:50:23,622
CENTER, CURRENT FUNDING

9456
05:50:23,622 --> 05:50:25,557
OPPORTUNITY NUMBER, TITLE OF THE

9457
05:50:25,557 --> 05:50:28,059
FUNDING OPPORTUNITY, ACTIVITY

9458
05:50:28,059 --> 05:50:31,229
CODES, FIRST WHEN IT WAS FIRST

9459
05:50:31,229 --> 05:50:33,999
ISSUED, THE DATE OF ISSUE, THE

9460
05:50:33,999 --> 05:50:35,867
FOR THE CURRENT FUNDING

9461
05:50:35,867 --> 05:50:37,669
OPPORTUNITY WHEN IT'S EXPIRING

9462
05:50:37,669 --> 05:50:39,571
THE NUMBER OF ISSUANCES, NUMBER

9463
05:50:39,571 --> 05:50:41,973
OF GRANTS AWARDED FOR THE

9464
05:50:41,973 --> 05:50:43,375
CURRENT ISSUANCE AND SOME NOTES,

9465
05:50:43,375 --> 05:50:47,078
AND I WILL TALK ABOUT THE NOTES

9466
05:50:47,078 --> 05:50:49,281
ELEMENT SO THE FIRST 3 FUNDING

9467
05:50:49,281 --> 05:50:50,315
TIEWPTS ANNOUNCE WANTS I'M GOING

9468
05:50:50,315 --> 05:50:54,452
TO TALK IS FROM THE CENTER FOR

9469
05:50:54,452 --> 05:50:56,187
REDUCING CANCER HEALTH

9470
05:50:56,187 --> 05:50:58,690
DISPARITIES, THE VERY FIRST 1 IS

9471
05:50:58,690 --> 05:51:01,526
NCI MENTORED CLINICAL SCIENTISTS

9472
05:51:01,526 --> 05:51:03,862
RESEARCH CAREER DEVELOPMENT TO

9473
05:51:03,862 --> 05:51:05,930
PROMOTE DIVERSITY AND 1 IS WITH

9474
05:51:05,930 --> 05:51:09,668
CLINICAL TRIAL REQUIRED AND THE

9475
05:51:09,668 --> 05:51:11,169
SECOND 1 IS CLINICAL TRIAL NOT

9476
05:51:11,169 --> 05:51:12,904
ALLOWED AND BOTH ARE K08.

9477
05:51:12,904 --> 05:51:15,907
AND IF YOU GO FROM LEFT TO RIGHT

9478
05:51:15,907 --> 05:51:19,544
AS I SAID, IT WAS FIRST ISSUED

9479
05:51:19,544 --> 05:51:21,980
IN 1997 AND THERE HAVE BEEN 9

9480
05:51:21,980 --> 05:51:25,250
PRIOR ISSUANCES IN THE CURRENT

9481
05:51:25,250 --> 05:51:26,451
FUNDING OPPORTUNITY THEY'RE

9482
05:51:26,451 --> 05:51:29,421
HAVING 4 AWARDS AND FOR--DEITION

9483
05:51:29,421 --> 05:51:31,756
HAS NOT BEEN MADE FOR FISCAL

9484
05:51:31,756 --> 05:51:32,991
YEAR 2024 YET.

9485
05:51:32,991 --> 05:51:34,025
THE SECOND 1 CREFRESH YOUR

9486
05:51:34,025 --> 05:51:36,227
RECOLLECTION CHD IS FOR NKRRK I

9487
05:51:36,227 --> 05:51:38,229
MENTORED RESEARCH SCIENTIST

9488
05:51:38,229 --> 05:51:41,166
DEVELOPMENT TO PROMOTE

9489
05:51:41,166 --> 05:51:42,901
DIVERSITY, K01 GRANT, THE 2 OF

9490
05:51:42,901 --> 05:51:44,803
THEM ARE AGAIN, INDEPENDENTLY

9491
05:51:44,803 --> 05:51:46,504
CLINICAL TRIALS, NOT ALLOWED,

9492
05:51:46,504 --> 05:51:51,009
AND CLINICAL TRIALS REQUIRED,

9493
05:51:51,009 --> 05:51:52,877
FIRST ISSUED IN 1998, AND THE

9494
05:51:52,877 --> 05:51:55,213
NUMBER OF ISSUANCES HAVE BEEN 10

9495
05:51:55,213 --> 05:51:57,649
AND CURRENTLY THERE HAVE BEEN 2

9496
05:51:57,649 --> 05:51:59,617
AWARD ANDS DECISION FOR 2024 HAS

9497
05:51:59,617 --> 05:52:01,953
NOT BEEN MADE.

9498
05:52:01,953 --> 05:52:05,457
THE THIRD 1 FOR CRCHD IS NCI

9499
05:52:05,457 --> 05:52:06,725
TRANSITION CAREER DEVELOPMENT

9500
05:52:06,725 --> 05:52:08,360
AWARD TO PROMOTE DIVERSITY,

9501
05:52:08,360 --> 05:52:10,395
AGAIN CLINICAL TRIALS NOT

9502
05:52:10,395 --> 05:52:11,830
ALLOWED AND CLINICAL TRIALS

9503
05:52:11,830 --> 05:52:14,899
REQUIRED, IT'S A K22.

9504
05:52:14,899 --> 05:52:16,968
FIRST ISSUED IN 2001 AND THE

9505
05:52:16,968 --> 05:52:19,971
EXPIRATION AND THE CURRENT 1

9506
05:52:19,971 --> 05:52:21,906
THAT'S ISSUED IN 2021, THE

9507
05:52:21,906 --> 05:52:24,209
NUMBER OF PRIOR ISSUANCES IS 9

9508
05:52:24,209 --> 05:52:25,777
AND THE NUMBER OF GRANTS AWARDED

9509
05:52:25,777 --> 05:52:26,845
IS 2 ISSUE THE AGAIN THE

9510
05:52:26,845 --> 05:52:28,546
DECISION FOR THE CURRENT FISCAL

9511
05:52:28,546 --> 05:52:30,415
YEAR HAS NOT BEEN MADE.

9512
05:52:30,415 --> 05:52:32,283
THE NEXT 2 IN BLUE ARE FROM

9513
05:52:32,283 --> 05:52:34,686
DIVISION OF CANCER BIOLOGY, THE

9514
05:52:34,686 --> 05:52:38,990
FITTER 1 FROM THE CANCER BIOLOGY

9515
05:52:38,990 --> 05:52:41,159
IS BASIC RESEARCH IN CANCER

9516
05:52:41,159 --> 05:52:42,527
HEALTH DISPARITIES RESEARCH.

9517
05:52:42,527 --> 05:52:46,931
WE HAVE THE 3 RO-1, R21 AND RO3

9518
05:52:46,931 --> 05:52:49,367
ACTIVITIES CODES.

9519
05:52:49,367 --> 05:52:50,235
INITIALLY SHOOTING 2015 AND THE

9520
05:52:50,235 --> 05:52:52,504
NUMBER OF PRIOR ISSUANCE FOR THE

9521
05:52:52,504 --> 05:52:56,508
OTHER 1 IS 2, FOR H214 AND RO3

9522
05:52:56,508 --> 05:52:58,076
IS 0, AWE LOOT THERE WERE NO

9523
05:52:58,076 --> 05:52:59,744
PRIOR ISSUANCES AND THE NUMBER

9524
05:52:59,744 --> 05:53:05,183
OF GRANTSA, WAKED TOTAL IS 21.

9525
05:53:05,183 --> 05:53:06,785
THE SECOND INITIATIVE FROM

9526
05:53:06,785 --> 05:53:09,220
CANCER OF BIOLOGY IS METASTASIS,

9527
05:53:09,220 --> 05:53:11,256
RESEARCH NETWORK OR MECHANISM IF

9528
05:53:11,256 --> 05:53:12,991
YOU THE RESEARCH PROGECS.

9529
05:53:12,991 --> 05:53:15,427
THIS IS A COOPERATIVE AGREEMENT

9530
05:53:15,427 --> 05:53:18,062
UO1 FIRST ISSUED IN 2022, AND

9531
05:53:18,062 --> 05:53:19,264
THERE HAVE BEEN 2 IMRANTS

9532
05:53:19,264 --> 05:53:22,901
AWARDED AND THEY ARE IN THE

9533
05:53:22,901 --> 05:53:25,970
PROCESS OF NOMINATING THROW

9534
05:53:25,970 --> 05:53:29,941
APPLICATIONS IN ROUND 2 IT SAYS.

9535
05:53:29,941 --> 05:53:34,145
THE NEXT 3 INITIATIVES ARE FROM

9536
05:53:34,145 --> 05:53:35,947
DIVISION OF CANCER CONTROL AND

9537
05:53:35,947 --> 05:53:37,549
POPULATION SCIENCES, THE FIRST 1

9538
05:53:37,549 --> 05:53:40,351
IS THE DISSEMINATION AND

9539
05:53:40,351 --> 05:53:42,086
IMPLEMENTATION RESEARCH AND

9540
05:53:42,086 --> 05:53:45,390
HEALTH, AGAIN IT IS R01, R21

9541
05:53:45,390 --> 05:53:45,723
XR03.

9542
05:53:45,723 --> 05:53:48,927
FIRST ISSUED IN NEEN 1999 AND

9543
05:53:48,927 --> 05:53:52,397
THE NUMBER OF PRIOR ISSUANCES

9544
05:53:52,397 --> 05:53:55,400
FOR THIS INITIATIVE IS 9 FOR

9545
05:53:55,400 --> 05:53:58,136
R01, AND 8 FOR R03, THERE HAVE

9546
05:53:58,136 --> 05:54:00,004
BEEN 4 AWARDS MADE IN THE

9547
05:54:00,004 --> 05:54:02,974
CURRENT ISSUANCE OF FUNDING

9548
05:54:02,974 --> 05:54:04,943
OPPORTUNITY 2 ARE PENDING, THE

9549
05:54:04,943 --> 05:54:07,712
TOTAL AWARDS FROM MIRE ISSUANCE

9550
05:54:07,712 --> 05:54:09,147
IS 56.

9551
05:54:09,147 --> 05:54:12,917
THE SECOND INITIATIVE FROM DCCPS

9552
05:54:12,917 --> 05:54:14,319
IS CANCER EPIDEMIOLOGY COHORT

9553
05:54:14,319 --> 05:54:17,856
BUILDING THE NEXT GENERATION OF

9554
05:54:17,856 --> 05:54:19,057
RESEARCH COHORTS, COOPERATIVE

9555
05:54:19,057 --> 05:54:22,827
AGREEMENT AND THE FOLLOWING 1 IS

9556
05:54:22,827 --> 05:54:24,229
RESEARCH OPPORTUNITIES FOR

9557
05:54:24,229 --> 05:54:26,164
ESTABLISH CANCER EPIDEMIOLOGY

9558
05:54:26,164 --> 05:54:28,566
COHORT STUDIES AGAIN COOPERATIVE

9559
05:54:28,566 --> 05:54:32,737
AGREEMENT, FIRST ISSUED IN 2022,

9560
05:54:32,737 --> 05:54:35,640
AND THE NUMBER OF GLANCES ON THE

9561
05:54:35,640 --> 05:54:36,875
CANCER EPIDEMIOLOGY COHORTS

9562
05:54:36,875 --> 05:54:38,877
BUILDING THE NEXT GENERATION

9563
05:54:38,877 --> 05:54:42,514
COHORTS, THE OTHER 1 IS 1 GRANT.

9564
05:54:42,514 --> 05:54:45,850
THE FINAL 1 FROM DCCPS IS

9565
05:54:45,850 --> 05:54:48,520
CLINICAL CHARACTERIZATION OF

9566
05:54:48,520 --> 05:54:49,888
CANCER THERAPY INDUCED ADVERSE

9567
05:54:49,888 --> 05:54:51,990
EQUALLY AND MECHANISM BASED

9568
05:54:51,990 --> 05:54:53,491
INTERVENTIONAL STRATEGIES IT'S

9569
05:54:53,491 --> 05:54:57,262
AN RO-1 ACTIVITY CODE INITIALLY,

9570
05:54:57,262 --> 05:55:01,766
SHOWED IN 2019, AND 1 PRIOR

9571
05:55:01,766 --> 05:55:03,434
ISSUANCE WITH 12 GRANTS AND

9572
05:55:03,434 --> 05:55:06,337
THERE WERE 9 AWARDS FROM THE

9573
05:55:06,337 --> 05:55:07,772
PRIOR ISSUANCE.

9574
05:55:07,772 --> 05:55:09,340
MOVING ON, THERE ARE 3

9575
05:55:09,340 --> 05:55:11,509
INITIATIVES FROM DIVISION OF

9576
05:55:11,509 --> 05:55:13,344
CANCER PREVENTION ISSUE THE

9577
05:55:13,344 --> 05:55:15,880
FIRST 1 BEING MECHANISMS THAT

9578
05:55:15,880 --> 05:55:17,749
IMPACT CANCER RISK AFTER

9579
05:55:17,749 --> 05:55:20,952
BARIATRIC SURGERY, WE HAVE AN

9580
05:55:20,952 --> 05:55:24,556
R01 AND R21 ACTIVITY CODES FIRST

9581
05:55:24,556 --> 05:55:30,528
ISSUED IN 2021 CAN NAY HAVE BEEN

9582
05:55:30,528 --> 05:55:31,529
NO AWARDS.

9583
05:55:31,529 --> 05:55:32,864
THE SECOND INITIATED FROM THE

9584
05:55:32,864 --> 05:55:34,999
DIVISION OF CANCER PREVENTION

9585
05:55:34,999 --> 05:55:37,168
IS, CANCER PREVENTION AND

9586
05:55:37,168 --> 05:55:38,836
CONTROL CLINICAL TRIALS PLANNING

9587
05:55:38,836 --> 05:55:41,072
GRANT PROGRAMS, WE HAVE AN

9588
05:55:41,072 --> 05:55:44,609
RTHROWN--EQUALLY ARE AND I U34

9589
05:55:44,609 --> 05:55:45,677
U-BEING THE COOPERATIVE

9590
05:55:45,677 --> 05:55:47,679
AGREEMENT PLANNING GRANT FIRST

9591
05:55:47,679 --> 05:55:53,284
ISSUED IN 2022 AND THE NUMBER OF

9592
05:55:53,284 --> 05:55:55,820
IMRANTS FOR L31 IS 1 AND 3 FOR

9593
05:55:55,820 --> 05:55:58,056
THE U34S AND THE FINAL 1 FROM

9594
05:55:58,056 --> 05:56:01,326
DIVISION OF CANCER PREVENTION IS

9595
05:56:01,326 --> 05:56:03,728
UTILIZING THE FROSTED LUNG COAL

9596
05:56:03,728 --> 05:56:05,597
O RECTIFIEDOR AND BIOSPECIMENS

9597
05:56:05,597 --> 05:56:06,898
TO BRIDGE GAPS IN CANCER

9598
05:56:06,898 --> 05:56:08,166
ETIOLOGY AND EARLY DETECTION

9599
05:56:08,166 --> 05:56:11,836
RESEARCH EMPLOY WHICH IS A UO1

9600
05:56:11,836 --> 05:56:17,075
AGAIN, COOPERATIVE AGREEMENT

9601
05:56:17,075 --> 05:56:18,209
FIRST ISSUED IN 2012 AND THIS

9602
05:56:18,209 --> 05:56:19,677
HAVE BEEN 3 ISSUANCES AND

9603
05:56:19,677 --> 05:56:27,251
AWARDED IN THE CURRENT FUNDING

9604
05:56:27,251 --> 05:56:28,086
TIEWPTS 19.

9605
05:56:28,086 --> 05:56:29,787
WE HAVE 5 INITIATIVES FROM

9606
05:56:29,787 --> 05:56:31,789
DIVISION OF CANCER TREATMENT AND

9607
05:56:31,789 --> 05:56:33,758
DIAGNOSIS, THE FIRST 1 BEING

9608
05:56:33,758 --> 05:56:36,527
TOWARDS TRAMSALATION OF NANO

9609
05:56:36,527 --> 05:56:38,262
TECHNOLOGY, CANCER INTERVENTIONS

9610
05:56:38,262 --> 05:56:42,033
OR TTNCI, WHICH IS AN RO-1.

9611
05:56:42,033 --> 05:56:44,969
THE FIRST ISSUANCE WAS IN 2020

9612
05:56:44,969 --> 05:56:48,439
WITH 1 PRIOR ISSUANCE AND 6

9613
05:56:48,439 --> 05:56:51,342
AWARDS, THE SECOND 1 FROM DCTD

9614
05:56:51,342 --> 05:56:53,411
WOULD BE MOLECULAR IMAGING OF

9615
05:56:53,411 --> 05:56:56,047
INFLAMMATION AND CANCER AND RO-1

9616
05:56:56,047 --> 05:56:58,249
ACTIVITY CODE, FIRST ISSUED IN

9617
05:56:58,249 --> 05:57:02,487
2021 WITH 2 AWARDS, THE THIRD 1

9618
05:57:02,487 --> 05:57:03,921
FROM DCTDs INTEGRATION OF

9619
05:57:03,921 --> 05:57:06,157
IMAGING AND FLUID BASED TUMOR

9620
05:57:06,157 --> 05:57:08,893
MONITORING AND CANCER THERAPY,

9621
05:57:08,893 --> 05:57:10,528
RO-1 AGAIN, WITH 1 PRIOR

9622
05:57:10,528 --> 05:57:13,364
ISSUANCE AND 5 AWARDS.

9623
05:57:13,364 --> 05:57:22,407
AND THE FOURTH 1 IS EXPLORATORY

9624
05:57:22,407 --> 05:57:23,007
DEVELOPMENTAL BIOENGINEERING

9625
05:57:23,007 --> 05:57:25,810
RESEARCH GRANTS WHICH ARE CLIN

9626
05:57:25,810 --> 05:57:28,246
TRAL NOT ALLOWED AND BOGS OF

9627
05:57:28,246 --> 05:57:31,649
WHICH ARE ACTIVITY CODES FIRST

9628
05:57:31,649 --> 05:57:33,284
ISSUED IN 2019 AND PRIOR ASHANCE

9629
05:57:33,284 --> 05:57:35,386
IS 2 ANY FOR THE CLINICAL TRAIL

9630
05:57:35,386 --> 05:57:39,457
LOCKED AND LOADED HAVE BEEN 17

9631
05:57:39,457 --> 05:57:43,094
GRANTS AWARDED AND CUT IN THE

9632
05:57:43,094 --> 05:57:44,128
FUNDING OPPORTUNITY AND THERE

9633
05:57:44,128 --> 05:57:51,569
HAVE BEEN 7 AWARDS AWARDED.

9634
05:57:51,569 --> 05:57:52,637
AND BIOSPECIMEN APPROACHES INTO

9635
05:57:52,637 --> 05:57:57,608
CLINICAL ASSAY WITH DEVELOPMENT,

9636
05:57:57,608 --> 05:58:01,446
A UO1 ACTIVITY CODE WOOPRATIVE

9637
05:58:01,446 --> 05:58:03,548
AGREEMENT IN 20 SCWEAN WITH

9638
05:58:03,548 --> 05:58:05,049
PRIOR INSTANCES, THERE HAVE BEEN

9639
05:58:05,049 --> 05:58:07,585
6 AWARDS MADE AND 2 ARE PENDING.

9640
05:58:07,585 --> 05:58:09,687
FINALLY FROM OFFICE OF CANCER

9641
05:58:09,687 --> 05:58:14,892
CENTERS A P30 ACTIVITY CODE THE

9642
05:58:14,892 --> 05:58:16,828
FIRST 1, THE FIRST ISSUE OF THE

9643
05:58:16,828 --> 05:58:19,230
FUNDING OPPORTUNITY WAS IN 2010,

9644
05:58:19,230 --> 05:58:21,766
AND THERE HAVE BEEN 5 PRIOR

9645
05:58:21,766 --> 05:58:25,737
ISSUANCES, AND THE NUMBER OF

9646
05:58:25,737 --> 05:58:28,406
GRANTS AWARDED IS 32. 

9647
05:58:28,406 --> 05:58:29,340
THANK YOU.

9648
05:58:29,340 --> 05:58:30,274
>> THANK YOU, I SHOULD

9649
05:58:30,274 --> 05:58:32,710
INTRODUCED THE BOARD, AND THE

9650
05:58:32,710 --> 05:58:34,045
PAST HAS AGREED TO LUMP THESE

9651
05:58:34,045 --> 05:58:35,513
TOGETHER AND REHAVE YOU THEM ALL

9652
05:58:35,513 --> 05:58:35,747
AT ONCE.

9653
05:58:35,747 --> 05:58:39,517
THESE ARE NOT SET ASIDES.

9654
05:58:39,517 --> 05:58:41,519
THESE ARE THE PARs, THEY ARE

9655
05:58:41,519 --> 05:58:43,287
NOT RFAs AND SO THEY WILL BE

9656
05:58:43,287 --> 05:58:45,456
HANDLED BY TODAY SECTIONS AND

9657
05:58:45,456 --> 05:58:47,859
DECISIONS WILL BE MADE IN THE

9658
05:58:47,859 --> 05:58:50,528
NORMAL WAY.

9659
05:58:50,528 --> 05:58:54,732
SO DISCUSSION?

9660
05:58:54,732 --> 05:58:54,932
PARs?

9661
05:58:54,932 --> 05:58:56,334
>> YEAH, I JUST WANT TO
LET YOU

9662
05:58:56,334 --> 05:58:58,136
ALL KNOW BECAUSE IT'S SOMETHING

9663
05:58:58,136 --> 05:59:00,037
I WONDERED WHEN I WAS A PSA

9664
05:59:00,037 --> 05:59:01,973
MEMBER, SO WE REVIEW THESE AND

9665
05:59:01,973 --> 05:59:05,143
THIS YEAR, THERE WERE MANY, AND

9666
05:59:05,143 --> 05:59:06,911
WE TOOK IT SERIOUSLY, WE

9667
05:59:06,911 --> 05:59:08,613
REVIEWED THEM ALL WITH MULTIPLE

9668
05:59:08,613 --> 05:59:10,915
REVIEWERS TO INSURE THAT THEY

9669
05:59:10,915 --> 05:59:11,949
WERE WERE CONTINUING FORWARD,

9670
05:59:11,949 --> 05:59:16,120
THEY'RE NOT ALL HERE, IN SUN

9671
05:59:16,120 --> 05:59:18,089
SETTED BUT WE DO VALUE YOUR

9672
05:59:18,089 --> 05:59:19,957
INPUT BUT WE WANT TO YOU KNOW TO

9673
05:59:19,957 --> 05:59:28,533
WE WERE RIGOROUS IN LOOKING AT

9674
05:59:28,533 --> 05:59:29,033
THESE.

9675
05:59:29,033 --> 05:59:30,434
>> OTHER DISCUSSIONS OTHER
THAN

9676
05:59:30,434 --> 05:59:32,804
THANK HEAVENS THE CANCER CENTERS

9677
05:59:32,804 --> 05:59:33,271
GOTTEN RENEWED.

9678
05:59:33,271 --> 05:59:36,974
>> I HAVE A QUESTION.

9679
05:59:36,974 --> 05:59:37,141
YES.

9680
05:59:37,141 --> 05:59:38,976
>> SO WHEN WE WERE LOOKING
AT

9681
05:59:38,976 --> 05:59:39,811
THE CAREER DEVELOPMENT

9682
05:59:39,811 --> 05:59:41,546
SUBCOMMITTEE, I GUESS IT WAS

9683
05:59:41,546 --> 05:59:43,314
YEARS AGO, NOW, HERE, THERE WERE

9684
05:59:43,314 --> 05:59:46,918
SOME DISCUSSION ABOUT THE FACT

9685
05:59:46,918 --> 05:59:50,555
THAT CANCER CONTROL POPULATION

9686
05:59:50,555 --> 05:59:51,622
SCIENTISTS, THAT THEIR REAL

9687
05:59:51,622 --> 05:59:53,424
ACCESS TR CAREER DEVELOPMENT

9688
05:59:53,424 --> 05:59:55,893
AWARDS BUT THEY'RE THE K99 TO

9689
05:59:55,893 --> 05:59:57,395
R00 NIGHT ROUTINELY AND THERE

9690
05:59:57,395 --> 05:59:58,596
HAD BEEN DISCUSSION ABOUT THAT

9691
05:59:58,596 --> 06:00:00,798
WASN'T WORKING AS WELL AS WE HAD

9692
06:00:00,798 --> 06:00:02,967
HOPED AND THERE WAS A DISCUSSION

9693
06:00:02,967 --> 06:00:04,202
ABOUT OPENING BACK UP SOMETHING

9694
06:00:04,202 --> 06:00:08,039
THAT WAS AKIN TO THE OLD K07 AND

9695
06:00:08,039 --> 06:00:10,341
THEN WE'LL END OR MAYBE OPENING

9696
06:00:10,341 --> 06:00:12,977
UP THE K01 SO HAVE YOU 2 POOLS

9697
06:00:12,977 --> 06:00:15,780
LIKE AN APPLICANT OF K01S FOR

9698
06:00:15,780 --> 06:00:17,582
DIVERSITY AND ANOTHER POOL OF

9699
06:00:17,582 --> 06:00:18,049
THAT.

9700
06:00:18,049 --> 06:00:23,054
CAN WE KNOW WHAT'S GOING ON WITH

9701
06:00:23,054 --> 06:00:23,888
THAT?

9702
06:00:23,888 --> 06:00:24,255
N[INDISCERNIBLE]

9703
06:00:24,255 --> 06:00:26,157
>> YEAH, THANKS FOR THAT

9704
06:00:26,157 --> 06:00:26,424
QUESTION.

9705
06:00:26,424 --> 06:00:29,360
SO WE WERE REALLY EXCITED TO

9706
06:00:29,360 --> 06:00:33,664
WORK WITH THE CENTER FOR CANCER

9707
06:00:33,664 --> 06:00:35,733
TRAINING AND DEVELOP A K01

9708
06:00:35,733 --> 06:00:35,967
AWARD.

9709
06:00:35,967 --> 06:00:39,470
THIS IS A COLLABORATION BETWEEN

9710
06:00:39,470 --> 06:00:46,577
CCT, DCP AND DCCPS, SO THIS NEW

9711
06:00:46,577 --> 06:00:48,346
AWARD JUST BECAME AVAILABLE, THE

9712
06:00:48,346 --> 06:00:50,248
FIRST RECEIPT DATE WAS IN

9713
06:00:50,248 --> 06:00:53,885
FEBRUARY OF THIS YEAR, AND SO

9714
06:00:53,885 --> 06:00:59,757
IT'S A NEW K01 AND IT IS

9715
06:00:59,757 --> 06:01:02,827
RESTRICTED TO POPULATION

9716
06:01:02,827 --> 06:01:04,528
SCIENCES AND PREVENTION AND SO,

9717
06:01:04,528 --> 06:01:07,431
YOU NEED TO BE STUDYING IN 1 OF

9718
06:01:07,431 --> 06:01:09,600
THOSE AREAS IN ORDER TO RESPOND

9719
06:01:09,600 --> 06:01:12,136
TO THE NEW K01, BUT WE ARE

9720
06:01:12,136 --> 06:01:15,439
HOPING THAT THIS WILL FILL THE

9721
06:01:15,439 --> 06:01:18,643
GAP, THAT WAS NOTED THAT YOU

9722
06:01:18,643 --> 06:01:25,950
MENTIONED WHEN THE K07 WENT

9723
06:01:25,950 --> 06:01:26,284
AWAY.

9724
06:01:26,284 --> 06:01:32,924
KREK, IT'S OPEN TO EVERYONE.

9725
06:01:32,924 --> 06:01:37,395
NNOW WE'RE 1 MINUTE OVER.

9726
06:01:37,395 --> 06:01:41,365
>> I WAS JUST UNCLEAR WHY
WE

9727
06:01:41,365 --> 06:01:45,002
HAVE SO FEW AWARDS ON

9728
06:01:45,002 --> 06:01:45,870
IMMUNOLOGICAL COHORTS?

9729
06:01:45,870 --> 06:01:48,072
I THINK THERE'S ONLY 1 AWARDED

9730
06:01:48,072 --> 06:01:51,242
ON THE EPIDEMIOLOGY COHORTS AM I

9731
06:01:51,242 --> 06:01:52,543
CORRECT OR IS THERE A

9732
06:01:52,543 --> 06:01:52,843
CORRECTION?

9733
06:01:52,843 --> 06:01:54,412
>> THAT IS THE NUMBER THAT
WAS

9734
06:01:54,412 --> 06:01:57,381
LISTED THERE AND I'M GUESSING

9735
06:01:57,381 --> 06:02:00,584
THAT IT'S STILL PENDING THE DATA

9736
06:02:00,584 --> 06:02:02,086
FOR THIS YEAR NBECAUSE OUR LIST

9737
06:02:02,086 --> 06:02:04,855
OF INVESTIGATORS TEND TO USE

9738
06:02:04,855 --> 06:02:06,123
THOSE FOR [INDISCERNIBLE].

9739
06:02:06,123 --> 06:02:07,425
>> WE NEED TO--ANY OTHER
FURTHER

9740
06:02:07,425 --> 06:02:09,527
DISCUSSION, WE NEED TO HAVE A

9741
06:02:09,527 --> 06:02:13,497
VOTE DO I HAVE A MOTION TO

9742
06:02:13,497 --> 06:02:14,298
APPROVE?

9743
06:02:14,298 --> 06:02:15,733
SECOND?

9744
06:02:15,733 --> 06:02:16,067
OKAY.

9745
06:02:16,067 --> 06:02:20,905
THE VOTE IS EITHER TO CONCUR,

9746
06:02:20,905 --> 06:02:21,505
NONCONCUR OR DEFER?

9747
06:02:21,505 --> 06:02:23,975
SO WE WILL ASSUME THAT PEOPLE

9748
06:02:23,975 --> 06:02:25,142
ARE VOTING TO CONCUR.

9749
06:02:25,142 --> 06:02:29,814
ARE THERE ANY VOTES--OKAY, I'VE

9750
06:02:29,814 --> 06:02:32,483
BEEN TOLD TO ASK, HOW MANY

9751
06:02:32,483 --> 06:02:34,652
PEOPLE ARE VOTING TO CONCUR OF

9752
06:02:34,652 --> 06:02:43,761
THE BSA IN RAISE YOUR HANDS.

9753
06:02:43,761 --> 06:02:47,365
ARE THERE ANY VOTES NOT TO

9754
06:02:47,365 --> 06:02:52,303
CONCUR EMPLOY ANY ABSTENTIONS,

9755
06:02:52,303 --> 06:02:53,971
OKAY, SO IT'S UNANIMOUS AND WE

9756
06:02:53,971 --> 06:02:59,143
HAD A QUORUM  QUORUM.

9757
06:02:59,143 --> 06:03:00,678
OKAY, I THINK THAT'S DONE WITH

9758
06:03:00,678 --> 06:03:06,283
THE BSA BUSINESS FOR THE DAY.

9759
06:03:06,283 --> 06:03:08,786
SO, THIS CONCLUDES THE OPEN 


9760
06:03:08,786 --> 06:03:18,786
SESSION.