1
00:00:08,922 --> 00:00:12,593
>> OKAY, CAN EVERYONE TAKE
A

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00:00:12,593 --> 00:00:15,529
SEAT SOMEWHERE IF YOU'RE

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00:00:15,529 --> 00:00:17,364
COMFORTABLE.

4
00:00:17,364 --> 00:00:19,132
I'M GIVEN AN AGENDA THAT IS

5
00:00:19,132 --> 00:00:21,668
REALLY JAM-PACKED, SO WE'RE

6
00:00:21,668 --> 00:00:23,670
ALREADY 9 MINUTES LATE SO WE

7
00:00:23,670 --> 00:00:34,214
HAVE TO SOMEHOW TRY TO CATCH UP.

8
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SO THANK YOU ALL FOR BEING HERE.

9
00:00:42,923 --> 00:00:44,858
BUT THE CHIEF GUEST OF THIS

10
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EVENING IS DR. KRAEMER, AND WE

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ARE HERE TO CELEBRATE THIS

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ILLUSTRIOUS INNOVATIVE, CARING

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AND EXPANSIVE CAREER HE HAS

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GIVEN TO US IN THE LAST 50 YEARS

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OR SO AT NIH.

16
00:01:03,710 --> 00:01:05,445
SO IT'S A GREAT PLEASURE FOR ME

17
00:01:05,445 --> 00:01:08,815
TO BE INTRODUCING YOU.

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I MET KEN DURING MY INTERVIEWS

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WHEN I WAS LOOKING FOR A

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POSITION HERE, AND THAT'S WHEN I

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SORT OF LEARNED ABOUT HIS WORK

22
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AND WHAT HE HAS DONE.

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IT WAS INSPIRING BECAUSE IT'S

24
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ONE OF THOSE THINGS, A VERY IN

25
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DEPTH ANALYSIS OF WHAT SEEMS TO

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BE A SMALL QUESTION, BUT THE

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IMPACT AND THE INSIGHTS HE GOT

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FROM THEM WERE VAST AND

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EXPANSIVE, LIKELY TO HAVE AN

30
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IMPACT ON MANY, MANY PATIENTS.

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SO AS I LEARNED MORE AND MORE

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ABOUT KEN, I REALIZED THAT HE

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HAD ACTUALLY MADE SUCH A

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CONTRIBUTION TO SCIENCE THAT IS

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UNLIKE ANY OTHER, AND YOU NEED

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TO BE IN A PLACE LIKE NCI TO DO

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00:01:51,058 --> 00:01:55,529
IT BECAUSE IT REQUIRES VERY

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METICULOUS ANALYSIS THAT IS HARD

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TO DO OUTSIDE.

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AS I WAS ALSO THINKING ABOUT IT,

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YOU KNOW, WE ALL KNOW A LOT OF

42
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PEOPLE TRYING TO MAKE IMPACT IN

43
00:02:03,737 --> 00:02:06,139
OTHER PEOPLE'S LIVES BY HELPING

44
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THEM GROW HAIR.

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IT'S A BIG BUSINESS, AS YOU

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KNOW, AND THERE'S A BIG FOLL

47
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FOLLOWING AND ALL THAT.

48
00:02:17,317 --> 00:02:18,251
DR. KRAEMER, ON THE OTHER HAND,

49
00:02:18,251 --> 00:02:20,587
HAS IMPACTED SO MANY PEOPLE'S

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LIVES, AND THERE ARE PATIENTS

51
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WHO FOLLOW HIM DEARLY, BUT HE

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DOES THAT BY TAKING THEIR HAIR.

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[LAUGHTER]

54
00:02:28,895 --> 00:02:30,430
SO GO FIGURE THAT, RIGHT?

55
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SO HE HAS MADE A CAREER FOR

56
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HIMSELF AND ALSO TO BIOLOGY BY

57
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ACTUALLY ANALYZING SAMPLES OF

58
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PATIENTS' HAIR SAMPLES AND HE

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CONTINUES TO HAVE HIGHLY

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PRODUCTIVE DISCOVERIES THAT

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DELINEATE THE DIFFERENT TYPES OF

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PATIENTS AND SUBDISEASES AND HOW

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A SINGLE MUTATION CAN CAUSE

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MULTIPLE DIFFERENT DISEASES.

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THOSE KIND OF INSIGHTS ARE RARE

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TO COME UNLESS YOU HAVE SOME

67
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METICULOUS ANALYSIS LIKE THIS.

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NOW AFTER COMING HERE, I'VE

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INTERACTED WITH KEN MANY TIMES,

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AND I'VE BEEN VERY IMPRESSED BY

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HOW KIND, GENTLE, AND HUMBLE HE

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IS.

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00:03:08,068 --> 00:03:09,903
AND THE WAY HE CARES FOR HIS

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PEOPLE IS JUST UNLIKE ANY OTHER

75
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THAT I'VE COME ACROSS.

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SO I AM VERY IMPRESSED BY WHAT

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00:03:15,175 --> 00:03:16,910
YOU HAVE DONE SO FAR, AND VERY

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00:03:16,910 --> 00:03:18,111
IMPRESSED BY WHAT YOU HAVE DONE

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TO US AND GIVEN US TO LEARN FROM

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00:03:19,646 --> 00:03:22,382
YOU.

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SO I CONGRATULATE YOU ON YOUR

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00:03:25,452 --> 00:03:26,420
ILLUSTRIOUS CAREER HERE AND THE

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00:03:26,420 --> 00:03:29,389
INSPIRATION YO THAT WILL LIVE ON

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FOR ALL THE PEOPLE IN THIS ROOM

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00:03:30,924 --> 00:03:31,591
HERE AND OUTSIDE.

86
00:03:31,591 --> 00:03:32,659
SO THANK YOU FOR DOING THAT.

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LET'S GIVE A BIG ROUND OF

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APPLAUSE TO OUR CHIEF GUEST

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00:03:36,730 --> 00:03:36,930
TODAY.

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00:03:36,930 --> 00:03:42,836
[APPLAUSE]

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00:03:42,836 --> 00:03:44,371
SO I'M GOING TO GIVE A SMALL

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00:03:44,371 --> 00:03:46,440
TROPHY TO DR. KRAEMER, BUT I

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00:03:46,440 --> 00:03:47,874
WANT TO DO THAT IN FRONT OF HIS

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00:03:47,874 --> 00:03:48,642
FAMILY.

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SO I WANT ALL OF YOU TO COME UP.

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00:03:51,578 --> 00:03:54,548
SO THAT HE CAN RECEIVE THE GIFT

97
00:03:54,548 --> 00:03:56,283
IN FRONT OF YOU BECAUSE I THINK

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HE DESERVES TO HAVE YOU GUYS

99
00:03:59,586 --> 00:04:00,887
NEXT TO HIM.

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HE TALKS ABOUT YOU GUYS ALL THE

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TIME.

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[LAUGHTER]

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[INAUDIBLE] THIS IS A PLAQUE FOR

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OUTSTANDING ACHIEVEMENT, KEN

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KRAEMER.

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00:05:04,785 --> 00:05:07,120
[INAUDIBLE]

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[APPLAUSE]

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00:05:18,799 --> 00:05:20,534
>> CONGRATULATIONS.

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WELL-DESERVED.

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GETTING YOUR EXERCISE.

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AND I'LL BE TALKING AT THE END.

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>> SO BEFORE I WELCOME THE
NEXT

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SPEAKER, WHO IS GOING TO PRESENT

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SOMETHING ELSE TO DR. KRAEMER, I

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JUST WANT TO SAY THOMAS TULLY

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REGRETS DEEPLY HE WASN'T ABLE TO

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BE HERE WITH US ALL BUT HE SENDS

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HIS CON DW CONGRATULATIONS AND T

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WISHES FOR RETIRED LIFE.

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SO NEXT, I WOULD LIKE TO INVITE

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DR. CAROL PEALE, MAYBE YOU CAN

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START WITH GIVING HIM THE AWARD

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AND THEN THE PICTURE AND THEN

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YOU CAN SAY A FEW WORDS.

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[APPLAUSE]

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>> OKAY.

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WELL, IT'S A REAL PRIVILEGE FOR

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ME ON BEHALF OF THE CCR, FIRST

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OF ALL, IT'S A PRIVILEGE TO BE

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THE DEPUTY FOR THE LCBG, AND TO

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MEET ALL THE WONDERFUL PIs IN

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THAT GROUP, THOSE WHO WERE HERE

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AND THOSE WHO HAVE LEFT, BUT YOU

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KNOW, I HAVE MET KEN INDIRECTLY

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FOR MANY, MANY YEARS AGO, WHEN I

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FIRST CAME TO NIH, BECAUSE KEN'S

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GROUP HAD FAR-REACHING EFFECT,

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AND IT WAS THROUGH -- GIOVANNI

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THAT I MET AND LEARNED OF KEN'S

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WORK BECAUSE JOHN AND I SHARED A

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LOVE OF RETINOIDS, AND MY CAREER

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REALLY WAS FUNDAMENTALLY BASED

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ON THE PHENOMENON OF HOW RETINA

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GASES COULD CONTROL THE GROWTH

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OF NEUROBLASTOMA CELLS AND

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INDUCE DIFFERENTIATION.

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EVERYTHING I LEARNED ABOUT THE

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CLINICAL USE OF RET NOIDZ CAME

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FROM JOHN, AND SO WHO WAS REALLY

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INTEGRAL TO KEN'S GROUP, AND SO

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KEN NOT ONLY -- I THINK IT'S

152
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EMBLEMATIC OF THE REALLY ASTUTE

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CLINICIAN AND THE ABILITY TO

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TAKE ADVANTAGE OF THE TIMES AND

155
00:08:09,302 --> 00:08:13,673
MAKE REALLY GREAT DISCOVERIES.

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00:08:13,673 --> 00:08:14,774
BUT ALSO TO SEE AMONGST THE

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PEOPLE HE INTERACTED WITH A REAL

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LOVE FOR SCIENCE AND FOR TAKING

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CARE OF PATIENTS.

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AND THAT ASPECT -- I KNOW I WAS

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VERY INTRIGUED AT YOUR LAST SITE

162
00:08:25,385 --> 00:08:26,453
VISIT WHEN YOU TALKED ABOUT THE

163
00:08:26,453 --> 00:08:29,422
FACT THAT THERE MAY BE

164
00:08:29,422 --> 00:08:31,725
UNDERLYING MORE DNA REPAIR

165
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DEFECTS TO BE IDENTIFIED, AND SO

166
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I THINK IT'S A CHALLENGE TO THE

167
00:08:37,864 --> 00:08:39,499
COMMUNITY TO REALLY TAKE THIS UP

168
00:08:39,499 --> 00:08:41,234
AGAIN AND TO FOLLOW YOUR LINE OF

169
00:08:41,234 --> 00:08:41,668
RESEARCH.

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SO THANK YOU VERY MUCH FOR ALL

171
00:08:45,071 --> 00:08:45,505
YOU'VE DONE.

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[APPLAUSE]

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00:08:55,715 --> 00:08:56,983
>> THANK YOU, CAROL.

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00:08:56,983 --> 00:08:58,618
SO ALTHOUGH I SPEAK ON BEHALF OF

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00:08:58,618 --> 00:09:02,222
ALL THE PIs AND STAFF AT LCBG,

176
00:09:02,222 --> 00:09:03,523
I'VE KNOWN KEN ONLY FOR A VERY

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00:09:03,523 --> 00:09:04,958
SHORT TIME.

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THE PERSON THAT KNOWS HIM WELL

179
00:09:06,593 --> 00:09:08,028
IS GOING TO SPEAK NEXT.

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HE COULDN'T BE HERE IN PERSON

181
00:09:10,864 --> 00:09:11,731
UNFORTUNATELY, I'LL TURN IT OVER

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00:09:11,731 --> 00:09:12,632
TO STU.

183
00:09:12,632 --> 00:09:20,840
TAKE IT AWAY, STU.

184
00:09:20,840 --> 00:09:22,909
>> THANKS, SENTHIL.

185
00:09:22,909 --> 00:09:23,777
I'M SORRY I CAN'T BE THERE.

186
00:09:23,777 --> 00:09:25,645
KEN AND I GO BACK A LONG, LONG

187
00:09:25,645 --> 00:09:25,912
WAY.

188
00:09:25,912 --> 00:09:27,280
WE PUBLISHED A PAPER TOGETHER IN

189
00:09:27,280 --> 00:09:28,281
THE 80s.

190
00:09:28,281 --> 00:09:31,117
WHICH I LOOKED AT RECENTLY,

191
00:09:31,117 --> 00:09:32,852
HADN'T REMEMBERED TOO MUCH ABOUT

192
00:09:32,852 --> 00:09:34,687
IT, BUT IT WAS A PRETTY NICE

193
00:09:34,687 --> 00:09:39,959
PIECE OF WORK, AND I THINK KEN

194
00:09:39,959 --> 00:09:42,729
HAS DONE A LOT OF MUCH BETTER

195
00:09:42,729 --> 00:09:43,563
WORK SINCE THAT TIME.

196
00:09:43,563 --> 00:09:48,301
YOU KNOW, I'VE ALWAYS FELT THAT

197
00:09:48,301 --> 00:09:53,406
THE DISCOVERY BY JIM KLIEBER IN

198
00:09:53,406 --> 00:09:54,841
THE 60s OF THE RELATIONSHIP

199
00:09:54,841 --> 00:09:59,446
BETWEEN DNA REPAIR AND CANCER --

200
00:09:59,446 --> 00:10:00,480
DISEASE -- IS PROBABLY ONE OF

201
00:10:00,480 --> 00:10:02,048
THE MOST IMPORTANT HISTORICAL

202
00:10:02,048 --> 00:10:04,784
DISCOVERIES IN CANCER RESEARCH

203
00:10:04,784 --> 00:10:05,452
HISTORY.

204
00:10:05,452 --> 00:10:08,721
I THINK THAT FOR THE FIRST TIME

205
00:10:08,721 --> 00:10:12,025
REALLY POINTED TO DNA AS A MAJOR

206
00:10:12,025 --> 00:10:12,559
PLAYER.

207
00:10:12,559 --> 00:10:14,961
I THINK WHAT KEN HAS DONE SINCE

208
00:10:14,961 --> 00:10:16,830
THAT TIME HAS BEEN PRETTY

209
00:10:16,830 --> 00:10:20,667
EXTRAORDINARY AS WELL.

210
00:10:20,667 --> 00:10:23,837
HIS ABILITY TO ILLUMINATE OTHER

211
00:10:23,837 --> 00:10:25,338
DISEASES, A MUCH BROADER

212
00:10:25,338 --> 00:10:28,074
SPECTRUM OF DISEASES THAT CAROL

213
00:10:28,074 --> 00:10:29,609
REFERRED TO OVER A TIME RELATED

214
00:10:29,609 --> 00:10:32,445
TO MUTATIONS IN DNA REPAIR GENES

215
00:10:32,445 --> 00:10:35,782
HAS REALLY OPENED THE FIELD'S

216
00:10:35,782 --> 00:10:39,786
EYES TO THE FAR-RANGING PROBLEMS

217
00:10:39,786 --> 00:10:43,289
THAT CAN OCCUR AS A RESULT OF

218
00:10:43,289 --> 00:10:46,893
DNA REPAIR MISHAPS.

219
00:10:46,893 --> 00:10:48,995
KEN HAS FURTHER, I THINK, KEPT

220
00:10:48,995 --> 00:10:53,900
THE FIELD TOGETHER WITH HIS DNA

221
00:10:53,900 --> 00:10:55,001
REPAIR INTEREST GROUP.

222
00:10:55,001 --> 00:10:56,636
I HAVE NO IDEA HOW HE WAS ABLE

223
00:10:56,636 --> 00:10:59,906
TO DO IT 35 YEARS AGO, WHEN

224
00:10:59,906 --> 00:11:03,743
THERE WAS VERY LITTLE ABILITY TO

225
00:11:03,743 --> 00:11:05,078
COMMUNICATE ACROSS CONTINENTS,

226
00:11:05,078 --> 00:11:06,713
EVEN ACROSS THIS CONTINENT.

227
00:11:06,713 --> 00:11:09,649
BUT YET HE AND WILL MANAGED TO

228
00:11:09,649 --> 00:11:12,385
FIND A WAY TO KEEP THE FIELD

229
00:11:12,385 --> 00:11:13,586
TOGETHER AND THAT CONTINUES

230
00:11:13,586 --> 00:11:14,954
TODAY, AND FOR THOSE OF YOU WHO

231
00:11:14,954 --> 00:11:17,757
ARE ON THE MAILING LIST FROM

232
00:11:17,757 --> 00:11:23,530
THAT INTEREST GROUP, YOU CAN SEE

233
00:11:23,530 --> 00:11:25,398
AMAZINGLY HOW SO MANY IMPORTANT

234
00:11:25,398 --> 00:11:30,203
THINGS ARE TRANSMITTED THAT WAY.

235
00:11:30,203 --> 00:11:33,173
ANOTHER ASPECT THAT WE -- IT'S

236
00:11:33,173 --> 00:11:34,474
ALMOST UNIQUE, WAS THE

237
00:11:34,474 --> 00:11:38,278
COMPASSIONATE CARE THAT HE GAVE

238
00:11:38,278 --> 00:11:39,279
TO PATIENTS WITH A REALLY

239
00:11:39,279 --> 00:11:40,613
DIFFICULT DISEASE TO TAKE CARE

240
00:11:40,613 --> 00:11:44,851
OF, OFTEN OCCURRED -- USUALLY

241
00:11:44,851 --> 00:11:47,153
OCCURRED IN CHILDREN WITH A VERY

242
00:11:47,153 --> 00:11:48,621
DIFFICULT THING -- WAS A VERY

243
00:11:48,621 --> 00:11:50,123
DIFFICULT THING TO COMBAT AND

244
00:11:50,123 --> 00:11:53,626
LIVES WERE RUINED, BUT KEN AND

245
00:11:53,626 --> 00:11:57,130
JOHN AND DEBBY MANAGE DOLLARS TO

246
00:11:57,130 --> 00:11:58,264
HAVE A CLINIC LIKE NO OTHER IN

247
00:11:58,264 --> 00:11:59,632
THE WORLD TO HELP THESE PEOPLE

248
00:11:59,632 --> 00:12:02,268
GET THROUGH THIS TERRIBLE

249
00:12:02,268 --> 00:12:08,408
TRAGEDY THAT HAD FELL ON THEM.

250
00:12:08,408 --> 00:12:12,278
I JUST WANT TO SAY A WORD ABOUT

251
00:12:12,278 --> 00:12:16,983
KEN IN LCBG.

252
00:12:16,983 --> 00:12:18,751
KEN CAME -- HE HAD BEEN IN A

253
00:12:18,751 --> 00:12:23,690
NUMBER OF LABORATORIES OVER HIS

254
00:12:23,690 --> 00:12:26,292
CAREER BUT WHEN HE CAME TO LCBG,

255
00:12:26,292 --> 00:12:28,161
I THINK HE REALLY FOUND A HOME.

256
00:12:28,161 --> 00:12:30,096
I CAN TELL YOU THAT FOR ME, AN

257
00:12:30,096 --> 00:12:31,431
M.D., ONE OF THE FEW M.D.s IN

258
00:12:31,431 --> 00:12:33,066
THE LAB, HAVING CLINICIANS IN

259
00:12:33,066 --> 00:12:36,135
THE LAB WAS REALLY, REALLY

260
00:12:36,135 --> 00:12:42,141
IMPORTANT AND ENLIGHTENING AND

261
00:12:42,141 --> 00:12:44,978
THE MANY COMMENTS THAT KEN AND

262
00:12:44,978 --> 00:12:47,380
JOHN GAVE IN SEMINARS AND SO

263
00:12:47,380 --> 00:12:52,118
FORTH REALLY TOLD THE REST OF US

264
00:12:52,118 --> 00:12:53,553
THE RELEVANCE OF SOME OF THE

265
00:12:53,553 --> 00:12:54,721
BASIC RESEARCH FINDINGS.

266
00:12:54,721 --> 00:12:57,557
AND SO THAT WAS VERY, VERY

267
00:12:57,557 --> 00:13:01,227
EXCITING FOR ME TO HAVE KEN IN

268
00:13:01,227 --> 00:13:03,263
THE LAB TO NOT ONLY DO HIS OWN

269
00:13:03,263 --> 00:13:06,332
WORK BUT TO EDUCATE THE RETION

270
00:13:06,332 --> 00:13:10,370
REST OFUS ON THE IMPORTANCE, THE

271
00:13:10,370 --> 00:13:12,305
CLINICAL RELEVANCE, OF BASIC

272
00:13:12,305 --> 00:13:13,206
RESEARCH FINDINGS.

273
00:13:13,206 --> 00:13:17,277
SO I THINK I WENT THROUGH TWO

274
00:13:17,277 --> 00:13:18,578
SITE VISITS WITH KEN IN LCBG,

275
00:13:18,578 --> 00:13:20,346
AND I HAVE BEEN THROUGH A LOT OF

276
00:13:20,346 --> 00:13:24,484
SITE VISITS, BOTH WITHIN MY OWN

277
00:13:24,484 --> 00:13:27,320
CAREER AND THE CAREER OF OTHERS

278
00:13:27,320 --> 00:13:30,823
BECAUSE OF MY TENURE AS A DEPUTY

279
00:13:30,823 --> 00:13:33,893
DIRECTOR FOR SOME YEARS.

280
00:13:33,893 --> 00:13:35,328
KEN IS THE ONLY PERSON WHO WAS

281
00:13:35,328 --> 00:13:40,233
CALLED A NATIONAL TREASURE.

282
00:13:40,233 --> 00:13:41,768
I'D NEVER SEEN THAT IN ANOTHER

283
00:13:41,768 --> 00:13:43,603
SITE VISIT REPORT, BUT I THINK

284
00:13:43,603 --> 00:13:45,305
HE GOT IT IN BOTH OF HIS

285
00:13:45,305 --> 00:13:49,108
REPORTS.

286
00:13:49,108 --> 00:13:51,177
HIS WORK AND KEN WERE DEEMED TO

287
00:13:51,177 --> 00:13:55,214
BE A NATIONAL TREASURE.

288
00:13:55,214 --> 00:13:56,316
AND ONE MORE THING THAT MAYBE

289
00:13:56,316 --> 00:14:00,253
WILL COME UP IN SOME OTHER

290
00:14:00,253 --> 00:14:01,654
PRESENTATION BUT BECAUSE I'M IN

291
00:14:01,654 --> 00:14:04,691
THE SKIN FIELD, AND ATTENDED THE

292
00:14:04,691 --> 00:14:07,026
SOCIETY OF INVESTIGATIVE

293
00:14:07,026 --> 00:14:10,096
DERMATOLOGY MEETINGS, ONE VERY

294
00:14:10,096 --> 00:14:12,598
UNIQUE THING THAT KEN DEVELOPED,

295
00:14:12,598 --> 00:14:14,467
I THINK WE'LL HEAR ABOUT HIS

296
00:14:14,467 --> 00:14:17,003
MENTORING FROM HIS DIRECT

297
00:14:17,003 --> 00:14:20,473
MENTORS, BUT EVERY YEAR WHEN THE

298
00:14:20,473 --> 00:14:22,141
SID MEETING WAS HELD, AGAIN I'M

299
00:14:22,141 --> 00:14:24,310
NOT SURE HOW HE PULLED THIS OFF,

300
00:14:24,310 --> 00:14:26,813
BUT KEN WAS ABLE TO HARNESS A

301
00:14:26,813 --> 00:14:28,281
POSSE OF HIGH SCHOOL STUDENTS

302
00:14:28,281 --> 00:14:31,751
AND BROUGHT THEM TO THE MEETING,

303
00:14:31,751 --> 00:14:34,387
PUT THEM IN SESSIONS, HAD THEM

304
00:14:34,387 --> 00:14:37,323
INTRODUCED TO SPEAKER, WAS

305
00:14:37,323 --> 00:14:39,892
REALLY SOMETHING TO SEE AND MUST

306
00:14:39,892 --> 00:14:42,695
HAVE BEEN VERY DIFFICULT TO

307
00:14:42,695 --> 00:14:44,230
ORGANIZE.

308
00:14:44,230 --> 00:14:45,598
I DON'T THINK THERE'S A WAY TO

309
00:14:45,598 --> 00:14:46,733
KNOW BUT I WONDER HOW MANY OF

310
00:14:46,733 --> 00:14:49,369
THOSE KIDS WHO CAME IN CITIES

311
00:14:49,369 --> 00:14:51,437
ALL OVER THE COUNTRY ULTIMATELY

312
00:14:51,437 --> 00:14:54,173
CHOSE MEDICINE OR EVEN

313
00:14:54,173 --> 00:14:57,577
DERMATOLOGY AS THEIR FIELD.

314
00:14:57,577 --> 00:14:58,711
SO I THINK WE HAVE A LOT TO

315
00:14:58,711 --> 00:14:59,846
THANK YOU FOR, KEN.

316
00:14:59,846 --> 00:15:03,483
BEFORE I STOP, I WANT TO SAY

317
00:15:03,483 --> 00:15:05,885
SOMETHING ABOUT -- SOMETHING

318
00:15:05,885 --> 00:15:07,186
THAT PERHAPS I'M THE ONLY ONE

319
00:15:07,186 --> 00:15:11,023
WHO COULD SAY IT.

320
00:15:11,023 --> 00:15:12,558
SO DORIS ACCOMPANIED KEN TO

321
00:15:12,558 --> 00:15:13,860
ALMOST EVERY MEETING I EVER

322
00:15:13,860 --> 00:15:14,961
ATTENDED WITH THEM.

323
00:15:14,961 --> 00:15:16,162
AND IT WAS ALWAYS WONDERFUL TO

324
00:15:16,162 --> 00:15:18,030
SEE THEM TOGETHER.

325
00:15:18,030 --> 00:15:20,099
BUT DORIS HAD HER OWN ROLE.

326
00:15:20,099 --> 00:15:21,868
DORIS WAS A SCIENCE TEACHER AT

327
00:15:21,868 --> 00:15:25,571
CHURCHILL HIGH SCHOOL, AND ONE

328
00:15:25,571 --> 00:15:26,873
OF THE THINGS THAT SEPARATED

329
00:15:26,873 --> 00:15:30,710
DORIS FROM OTHER SCIENCE TEAC 

330
00:15:30,710 --> 00:15:32,245
TEACHERS WAS HER ACTING SKILLS.

331
00:15:32,245 --> 00:15:34,380
SO EVERY YEAR, CHURCHILL PUT ON

332
00:15:34,380 --> 00:15:37,350
A PLAY, A FALL PLAY, I THINK IT

333
00:15:37,350 --> 00:15:38,818
WAS, THAT WAS VERY HIGHLY

334
00:15:38,818 --> 00:15:40,086
ATTENDED, WENT ON FOR FOUR

335
00:15:40,086 --> 00:15:42,321
NIGHTS AND EVERYONE LOVED IT.

336
00:15:42,321 --> 00:15:43,956
BUT THERE WAS A FACULTY MEMBER

337
00:15:43,956 --> 00:15:46,025
IN THOSE PLAYS, AND THAT WAS

338
00:15:46,025 --> 00:15:47,727
DORIS.

339
00:15:47,727 --> 00:15:49,529
DORIS ACTED -- ALWAYS HAD A ROLE

340
00:15:49,529 --> 00:15:50,963
IN THOSE PLAYS, AND I CAN TELL

341
00:15:50,963 --> 00:15:53,566
YOU THAT EVERY TIME SHE CAME OUT

342
00:15:53,566 --> 00:15:58,070
ON STAGE, THE LOUDEST APPLAUSE

343
00:15:58,070 --> 00:16:02,542
OF ANYONE ON THAT ENSEMBLE.

344
00:16:02,542 --> 00:16:05,378
SO IN ADDITION TO BEING A

345
00:16:05,378 --> 00:16:07,146
SCIENCE TEACHER AND RAISING FOUR

346
00:16:07,146 --> 00:16:10,082
KIDS, WE HAVE TO GIVE DORIS SOME

347
00:16:10,082 --> 00:16:15,588
KUDOS FOR HER ACTING SKILLS.

348
00:16:15,588 --> 00:16:24,630
[APPLAUSE]

349
00:16:24,630 --> 00:16:26,499
AND THE LIVES YOU'VE TOUCHED,

350
00:16:26,499 --> 00:16:28,468
BOTH YOUR TRAINEES, YOUR

351
00:16:28,468 --> 00:16:30,069
COLLEAGUES, AND THE PATIENTS WHO

352
00:16:30,069 --> 00:16:34,273
YOU HELPED TO GET THROUGH A VERY

353
00:16:34,273 --> 00:16:36,008
DIFFICULT SET OF DISEASES.

354
00:16:36,008 --> 00:16:38,311
SO WE ALL REALLY OWE YOU A GREAT

355
00:16:38,311 --> 00:16:41,280
DEAL OF APPRECIATION, AND IT'S

356
00:16:41,280 --> 00:16:43,182
BEEN A PLEASURE WORKING WITH YOU

357
00:16:43,182 --> 00:16:45,551
OVER THE YEARS.

358
00:16:45,551 --> 00:16:46,419
 YOU WERE IN LCBG.

359
00:16:46,419 --> 00:16:47,420
THANK YOU.

360
00:16:47,420 --> 00:16:56,295
[APPLAUSE]

361
00:16:56,295 --> 00:16:57,563
>> THANK YOU, STU.

362
00:16:57,563 --> 00:16:58,431
THAT WAS AMAZING.

363
00:16:58,431 --> 00:17:00,066
GOES TO SHOW HOW WELL HE KNOWS

364
00:17:00,066 --> 00:17:01,501
KEN.

365
00:17:01,501 --> 00:17:04,203
NEXT I WOULD LIKE TO CALL UPON

366
00:17:04,203 --> 00:17:14,447
VILHELM BOHR.

367
00:17:18,184 --> 00:17:19,452
>> JEROME, CAN YOU SEND ME
A

368
00:17:19,452 --> 00:17:24,357
CHAT ABOUT HOW TO ENLARGE THE --

369
00:17:24,357 --> 00:17:25,691
WHERE WE SEE EACH INDIVIDUAL ON

370
00:17:25,691 --> 00:17:35,902
THE SCREEN?

371
00:17:38,638 --> 00:17:40,673
DEAR KEN.

372
00:17:40,673 --> 00:17:43,142
CONGRATULATIONS AND I ALSO WISH

373
00:17:43,142 --> 00:17:46,012
TO EXPRESS MY MANY THANKS FOR

374
00:17:46,012 --> 00:17:49,515
YOUR FRIENDSHIP, WHICH HAS BEEN

375
00:17:49,515 --> 00:17:50,416
VERY IMPORTANT OVER THE YEARS.

376
00:17:50,416 --> 00:17:51,717
WE'VE WORKED TOGETHER FOR SO

377
00:17:51,717 --> 00:17:53,553
MANY YEARS.

378
00:17:53,553 --> 00:17:56,756
AND THIS EXTENDS FROM

379
00:17:56,756 --> 00:17:58,858
DISCUSSIONS ABOUT SCIENCE TO

380
00:17:58,858 --> 00:18:00,660
PRACTICAL DISCUSSIONS ABOUT THIS

381
00:18:00,660 --> 00:18:02,428
DNA REPAIR INTEREST GROUP TO

382
00:18:02,428 --> 00:18:03,729
MANY OTHER THINGS AND MANY

383
00:18:03,729 --> 00:18:06,265
MEETINGS THAT WE HAVE SHARED.

384
00:18:06,265 --> 00:18:07,466
I'LL SHOW A FEW PICTURES FROM

385
00:18:07,466 --> 00:18:07,800
IT.

386
00:18:07,800 --> 00:18:11,404
AND I' I'LL FOCUS ON THE WORK TT

387
00:18:11,404 --> 00:18:12,605
WE'VE DONE TOGETHER IN THE

388
00:18:12,605 --> 00:18:14,574
INTEREST GROUP.

389
00:18:14,574 --> 00:18:17,843
BUT ALSO YOU AND I HAVE SHARED

390
00:18:17,843 --> 00:18:19,178
SOME MEETINGS THAT WERE REALLY

391
00:18:19,178 --> 00:18:23,950
INTERESTING WHERE WE -- AS STU

392
00:18:23,950 --> 00:18:25,184
JUST MENTIONED TO THE CLINICAL

393
00:18:25,184 --> 00:18:28,020
PEOPLE, THE BASIC PEOPLE, AND WE

394
00:18:28,020 --> 00:18:31,524
REALLY, I THINK, WERE -- IT WAS

395
00:18:31,524 --> 00:18:34,460
A BIT NULL AT THE TIME AT LEAST

396
00:18:34,460 --> 00:18:35,795
IN DNA REPAIR TO BRING PEOPLE

397
00:18:35,795 --> 00:18:37,630
TOGETHER LIKE THAT.

398
00:18:37,630 --> 00:18:38,965
FOR SOME OF THE SCIENTISTS TO

399
00:18:38,965 --> 00:18:41,367
SEE AN ACTUAL PATIENT WAS A VERY

400
00:18:41,367 --> 00:18:43,102
NEW THING IN THEIR EXPERIENCE,

401
00:18:43,102 --> 00:18:45,838
AND WE HAD MANY SCIENTISTS THAT

402
00:18:45,838 --> 00:18:47,607
LEARNED A LOT FROM THAT AND THAT

403
00:18:47,607 --> 00:18:49,875
CHANGED THE DIRECTIONS OF WHERE

404
00:18:49,875 --> 00:18:52,945
THEY WERE GOING.

405
00:18:52,945 --> 00:18:55,681
SO ALSO WE PUBLISHED SOME PAPERS

406
00:18:55,681 --> 00:18:57,350
TOGETHER AND THE BEST WISHES

407
00:18:57,350 --> 00:19:01,187
GOING FORWARD.

408
00:19:01,187 --> 00:19:02,788
I WAS ASKED TO SAY A LITTLE

409
00:19:02,788 --> 00:19:07,126
ABOUT THIS GROUP GROUP DNA REPAT

410
00:19:07,126 --> 00:19:07,393
GROUP.

411
00:19:07,393 --> 00:19:09,795
IT STARTED WAY BACK IN 1986.

412
00:19:09,795 --> 00:19:13,466
I CAME FR TO THE NIH FROM STANF,

413
00:19:13,466 --> 00:19:14,834
I HAD BEEN WORKING FOR SEVERAL

414
00:19:14,834 --> 00:19:16,168
YEARS AT THE TIME IN DNA REPAIR

415
00:19:16,168 --> 00:19:17,870
AND I WAS LOOKING AT WHO WERE

416
00:19:17,870 --> 00:19:19,205
REALLY PROMINENT IN THE FIELD

417
00:19:19,205 --> 00:19:22,375
HERE, AND OF COURSE THAT WAS

418
00:19:22,375 --> 00:19:24,343
KEN, SO I WALKED UP TO KEN AND

419
00:19:24,343 --> 00:19:26,212
SAID WHY DON'T WE HAVE SOME

420
00:19:26,212 --> 00:19:27,279
SEMINAR TOGETHER?

421
00:19:27,279 --> 00:19:28,614
AT FIRST KEN SAID, WELL, I'M NOT

422
00:19:28,614 --> 00:19:32,652
SURE ABOUT THAT.

423
00:19:32,652 --> 00:19:34,487
AND THEN LATER HE AGREED AND

424
00:19:34,487 --> 00:19:36,155
OVER THE YEARS ACTUALLY BECAME

425
00:19:36,155 --> 00:19:38,658
THE MOST ENERGETIC OF THE TWO OF

426
00:19:38,658 --> 00:19:40,559
US MAYBE IN ALL THESE JOINT

427
00:19:40,559 --> 00:19:44,597
MEETINGS THAT WE HAD.

428
00:19:44,597 --> 00:19:47,433
SO THAT STARTED THE DNA REPAIR

429
00:19:47,433 --> 00:19:48,968
INTEREST GROUP.

430
00:19:48,968 --> 00:19:52,038
BACK THEN WE BEGAN MAYBE IN -- I

431
00:19:52,038 --> 00:19:55,975
WOULD SAY 86:00, MAYBE 85:00,

432
00:19:55,975 --> 00:19:57,376
AND THEN WE HAD A NUMBER OF

433
00:19:57,376 --> 00:20:01,547
CONFERENCES THAT WERE FIRST IN

434
00:20:01,547 --> 00:20:02,848
PERSON, BUILDING 37 WHERE WE

435
00:20:02,848 --> 00:20:04,050
INVITED SOME SPEAKERS IN, AND

436
00:20:04,050 --> 00:20:06,252
THEY WERE ACTUALLY SUCCESSFUL

437
00:20:06,252 --> 00:20:08,421
BECAUSE WE WERE ABLE TO FIND

438
00:20:08,421 --> 00:20:10,289
MANY CANDIDATES THAT LATER GOT

439
00:20:10,289 --> 00:20:11,457
SOME GOOD JOB OPPORTUNITIES OUT

440
00:20:11,457 --> 00:20:13,993
OF THIS.

441
00:20:13,993 --> 00:20:17,730
AND THEN WE HAD THESE VERY

442
00:20:17,730 --> 00:20:18,764
ELABORATE VIDEO CONFERENCES AT

443
00:20:18,764 --> 00:20:20,232
THE TIME THAT THIS WAS VERY

444
00:20:20,232 --> 00:20:22,001
NOVEL TO HAVE VIDEO CONFERENCES

445
00:20:22,001 --> 00:20:25,705
AND VERY CHALLENGING.

446
00:20:25,705 --> 00:20:27,206
AND WE HAD THESE MANY SITES ALL

447
00:20:27,206 --> 00:20:28,674
OVER THE U.S. AND WE HAD TO

448
00:20:28,674 --> 00:20:31,711
COORDINATE ALL THIS VIDEO

449
00:20:31,711 --> 00:20:35,347
TRANSFER BETWEEN THE SITES, AND

450
00:20:35,347 --> 00:20:37,850
THEN WE STARTED ARCHIVING THE

451
00:20:37,850 --> 00:20:41,587
LECTURES, AND WE HAD A LONG LIST

452
00:20:41,587 --> 00:20:43,756
OF PEOPLE WHO GOT EMAILED, THIS

453
00:20:43,756 --> 00:20:45,391
WAS MAINLY DONE BY YOU, KEN.

454
00:20:45,391 --> 00:20:48,694
IT WAS A GREAT EFFORT TO INFORM

455
00:20:48,694 --> 00:20:50,329
PEOPLE ABOUT MEETINGS AND OTHER

456
00:20:50,329 --> 00:20:52,932
THINGS AND LATER THIS GREW TO BE

457
00:20:52,932 --> 00:20:54,467
INFORMING ABOUT JOB

458
00:20:54,467 --> 00:20:56,769
OPPORTUNITIES, ABOUT DNA REPAIR

459
00:20:56,769 --> 00:21:01,807
MEETINGS WORLDWIDE.

460
00:21:01,807 --> 00:21:05,945
AND AT THE TIME HERE, IN 2009

461
00:21:05,945 --> 00:21:09,882
AND 10, WE MADE A HISTORIC

462
00:21:09,882 --> 00:21:11,517
COUPLE OF MEETINGS WHERE WE

463
00:21:11,517 --> 00:21:18,224
SHOWED SOME OF THESE VIDEOS, AND

464
00:21:18,224 --> 00:21:19,425
WE HAD SOME REALLY

465
00:21:19,425 --> 00:21:20,159
INTERESTING -- IT WAS FIRST

466
00:21:20,159 --> 00:21:22,595
MENTIONED HERE THAT WE HAD A

467
00:21:22,595 --> 00:21:24,096
NUMBER OF LINKED SITES, WE HAD

468
00:21:24,096 --> 00:21:25,097
NATIONAL LABS AROUND THE

469
00:21:25,097 --> 00:21:26,398
COUNTRY, WE HAD UNIVERSITIES.

470
00:21:26,398 --> 00:21:29,235
SO IT WAS VERY COMPLICATED ADD

471
00:21:29,235 --> 00:21:30,903
CHALLENGING TO GET ALL THIS TO

472
00:21:30,903 --> 00:21:32,304
WORK, BUT IT USUALLY WORKED,

473
00:21:32,304 --> 00:21:34,874
ALTHOUGH WE HAD SOME CRASHES IN

474
00:21:34,874 --> 00:21:36,575
BETWEEN AS WELL.

475
00:21:36,575 --> 00:21:39,545
AND THIS IS JUST AN EXAMPLE OF

476
00:21:39,545 --> 00:21:41,280
BACK TO 2010, SOME OF THE

477
00:21:41,280 --> 00:21:43,582
SPEAKERS WE HAD AND MANY OF

478
00:21:43,582 --> 00:21:44,583
THESE ARE WELL-KNOWN TO YOU IN

479
00:21:44,583 --> 00:21:46,752
THE FIELD.

480
00:21:46,752 --> 00:21:51,557
IN THE END HERE, MAY 12, 2009,

481
00:21:51,557 --> 00:21:55,194
HISTORICAL COLLECTION AND THESE

482
00:21:55,194 --> 00:21:56,362
WERE SOME OF THE THINGS THAT WE

483
00:21:56,362 --> 00:21:59,765
SHOWED ON THAT OCCASION.

484
00:21:59,765 --> 00:22:06,505
SO FOR EXAMPLE, CARL SETLOY WAS

485
00:22:06,505 --> 00:22:08,307
A VERY IMPORTANT PERSON IN THE

486
00:22:08,307 --> 00:22:09,408
EARLY DISCOVERY OF NUTRITION

487
00:22:09,408 --> 00:22:10,042
REPAIR.

488
00:22:10,042 --> 00:22:11,544
THE FAMOUS TALK BY LARRY

489
00:22:11,544 --> 00:22:13,979
GROSSMAN WHO DISCOVERED MANY DNA

490
00:22:13,979 --> 00:22:15,314
REPAIR SIGNS WHERE HE ALSO

491
00:22:15,314 --> 00:22:16,715
TALKED ABOUT HIS -- HE WAS A

492
00:22:16,715 --> 00:22:22,421
FIGHTER PILOT IN THE WAR OVER IN

493
00:22:22,421 --> 00:22:25,491
JAPAN AND HAD VERY TRAUMATIC

494
00:22:25,491 --> 00:22:26,025
EXPERIENCES.

495
00:22:26,025 --> 00:22:29,528
WE HEARD ABOUT KLIBER'S TALK,

496
00:22:29,528 --> 00:22:31,697
BACK TO WHEN HE DISCOVERED THAT

497
00:22:31,697 --> 00:22:33,966
XP WAS ASSOCIATED WITH CANCER.

498
00:22:33,966 --> 00:22:36,836
WE HEARD ABOUT TRANSCRIPTION

499
00:22:36,836 --> 00:22:38,604
COUPLED REPAIR AND WE HAD SOME

500
00:22:38,604 --> 00:22:41,006
OTHER MEETINGS THAT TALKED ABOUT

501
00:22:41,006 --> 00:22:43,642
SOME CONTROVERSIAL WORK AT THE

502
00:22:43,642 --> 00:22:45,511
TIME.

503
00:22:45,511 --> 00:22:46,912
AND HERE IS ANOTHER LIST, JUST

504
00:22:46,912 --> 00:22:47,980
EXAMPLES OF PEOPLE THAT WE

505
00:22:47,980 --> 00:22:51,116
INVITED TO COME AND TALK, AND

506
00:22:51,116 --> 00:22:52,151
MANY OF THESE WILL BE VERY

507
00:22:52,151 --> 00:22:54,453
WELL-KNOWN TO YOU IN THIS

508
00:22:54,453 --> 00:22:55,788
AUDIENCE.

509
00:22:55,788 --> 00:22:59,158
WE HAD YOUNG PEOPLE TALK, WE HAD

510
00:22:59,158 --> 00:23:01,160
TUMOR INVESTIGATORS, SENIOR

511
00:23:01,160 --> 00:23:01,994
INVESTIGATORS AND HISTORICAL

512
00:23:01,994 --> 00:23:05,631
TALKS.

513
00:23:05,631 --> 00:23:08,367
AND THESE WERE SOME MORE VIDEOS

514
00:23:08,367 --> 00:23:12,071
THAT REFLECTED SPECIFIC VERY

515
00:23:12,071 --> 00:23:16,976
IMPORTANT COLLECTIONS BECAUSE

516
00:23:16,976 --> 00:23:18,410
MANY OF THESE PEOPLE HAVE SINCE

517
00:23:18,410 --> 00:23:19,678
PASSED AND NOW WE HAVE RECORDS

518
00:23:19,678 --> 00:23:23,549
AND THEY'RE STILL THERE IN THE

519
00:23:23,549 --> 00:23:25,084
DNA REPAIR GROUP AND WE SEE

520
00:23:25,084 --> 00:23:26,185
THESE PEOPLE AS THEY TALKED

521
00:23:26,185 --> 00:23:32,291
ABOUT THEIR WORK.

522
00:23:32,291 --> 00:23:35,561
CLONING THE ATM BETWEEN, THE

523
00:23:35,561 --> 00:23:36,795
VERY INTERESTING HISTORIC

524
00:23:36,795 --> 00:23:37,763
PERSPECTIVE AND OTHER PEOPLE

525
00:23:37,763 --> 00:23:41,834
THAT ARE WELL-KNOWN ON

526
00:23:41,834 --> 00:23:42,935
SENESCENCE AND AGING WHO HAS

527
00:23:42,935 --> 00:23:44,103
RECENTLY PASSED, AND THESE ARE

528
00:23:44,103 --> 00:23:46,105
RECORDS THAT WE NOW HAVE.

529
00:23:46,105 --> 00:23:48,607
MAINLY THANKS TO YOU, KEN,

530
00:23:48,607 --> 00:23:49,909
BECAUSE YOU PUSHED THAT, THAT WE

531
00:23:49,909 --> 00:23:51,210
SHOULD REALLY KEEP THESE THINGS

532
00:23:51,210 --> 00:23:52,411
AND THAT'S BEEN A TREASURE.

533
00:23:52,411 --> 00:23:58,784
AND HERE WE ARE AGAIN AT ONE OF

534
00:23:58,784 --> 00:24:00,185
OUR MEETINGS CHATTING TOGETHER A

535
00:24:00,185 --> 00:24:00,953
FEW YEARS AGO.

536
00:24:00,953 --> 00:24:03,923
SO THE DNA REPAIR INTEREST GROUP

537
00:24:03,923 --> 00:24:06,425
IS STILL GOING STRONG.

538
00:24:06,425 --> 00:24:10,896
THANKS TO THE EFFORTS OF THOSE

539
00:24:10,896 --> 00:24:13,866
WHO HAVE TAKEN THIS OVER AND WE

540
00:24:13,866 --> 00:24:17,236
HAVE A ADVISORY GROUP AND IT

541
00:24:17,236 --> 00:24:20,539
STILL GOES STRONG IN MONTHLY

542
00:24:20,539 --> 00:24:21,640
MEETINGS WITH VERY EXCITING

543
00:24:21,640 --> 00:24:22,174
TALKS.

544
00:24:22,174 --> 00:24:24,677
SO PLEASE KEEP LISTENING TO

545
00:24:24,677 --> 00:24:25,144
THOSE.

546
00:24:25,144 --> 00:24:29,014
AND KEN AND I, WE HAD MANY

547
00:24:29,014 --> 00:24:31,250
WONDERFUL EXPERIENCES IN

548
00:24:31,250 --> 00:24:35,087
MEETINGS AROUND THE WORLD, AND

549
00:24:35,087 --> 00:24:36,388
DORIS, IT WAS ALWAYS GOOD TO SEE

550
00:24:36,388 --> 00:24:37,690
YOU AT THE MEETINGS, MY WIFE

551
00:24:37,690 --> 00:24:38,857
ANNE USUALLY CAME ALONG, AND

552
00:24:38,857 --> 00:24:40,659
THIS WAS JUST ONE OF OUR EARLY

553
00:24:40,659 --> 00:24:43,295
DNA REPAIR MEETINGS, KEN, WE CAN

554
00:24:43,295 --> 00:24:51,070
SEE YOU HAD -- AND OTHER

555
00:24:51,070 --> 00:24:54,106
COLLEAGUES.

556
00:24:54,106 --> 00:24:55,874
SO I JUST WANT TO THEN THANK YOU

557
00:24:55,874 --> 00:24:57,309
FOR THIS GREAT COLLABORATION

558
00:24:57,309 --> 00:25:00,145
WE'VE HAD, AND FOR YOUR EFFORTS

559
00:25:00,145 --> 00:25:01,981
IN THE INTEREST GROUP AND FOR

560
00:25:01,981 --> 00:25:03,615
MANY OTHER THINGS, AND I KNOW

561
00:25:03,615 --> 00:25:04,717
WE'LL STAY IN TOUCH AND I WISH

562
00:25:04,717 --> 00:25:05,584
YOU THE VERY BEST, KEN.

563
00:25:05,584 --> 00:25:06,185
THANK YOU.

564
00:25:06,185 --> 00:25:16,362
[APPLAUSE]

565
00:25:19,465 --> 00:25:22,901
>> THANK YOU VERY MUCH,
VILHELM

566
00:25:22,901 --> 00:25:23,268
BOHR.

567
00:25:23,268 --> 00:25:27,039
NEXT I WOULD LIKE TO CALL UPON

568
00:25:27,039 --> 00:25:36,115
MARGARET TUCKER.

569
00:25:36,115 --> 00:25:37,750
IT'S CLEAR THAT YOU ARE

570
00:25:37,750 --> 00:25:39,284
TRAILBLAZERS, SETTING THE STAGE

571
00:25:39,284 --> 00:25:41,387
ON CONDITIONS THAT NEVER EXISTED

572
00:25:41,387 --> 00:25:42,955
WITH INTEREST GROUPS, NOW WE

573
00:25:42,955 --> 00:25:44,223
HAVE A LOT OF INTEREST GROUPS,

574
00:25:44,223 --> 00:25:48,060
SO GREAT JOB.

575
00:25:48,060 --> 00:25:49,261
>> GOOD AFTERNOON.

576
00:25:49,261 --> 00:25:51,764
I'M DEEPLY HONORED TO BE PART OF

577
00:25:51,764 --> 00:25:53,832
THIS CELEBRATION OF KEN AND HIS

578
00:25:53,832 --> 00:25:55,334
MANY ACCOMPLISHMENTS.

579
00:25:55,334 --> 00:25:59,104
IT A TESTAMENT TO KEN'S

580
00:25:59,104 --> 00:26:01,106
COLLEGIALITY, GENEROSITY, AND

581
00:26:01,106 --> 00:26:04,443
BREADTH OF INTEREST THAT SO MANY

582
00:26:04,443 --> 00:26:06,311
SPEAKERS ARE ON THIS PROGRAM

583
00:26:06,311 --> 00:26:07,379
TODAY.

584
00:26:07,379 --> 00:26:08,814
I FIRST MET KEN IN THE LATE

585
00:26:08,814 --> 00:26:12,251
70s, WHEN I CAME TO THE NCI AS

586
00:26:12,251 --> 00:26:15,487
A CLINICAL FELLOW TO WORK IN THE

587
00:26:15,487 --> 00:26:18,991
EPIDEMIOLOGY BRANCH LED BY

588
00:26:18,991 --> 00:26:20,759
DR. JOE FARMINI.

589
00:26:20,759 --> 00:26:24,263
I HAD WORKED WITH DR. FRED LEE

590
00:26:24,263 --> 00:26:25,998
IN BOSTON FOR SEVERAL YEARS AS A

591
00:26:25,998 --> 00:26:26,999
MEDICAL STUDENT AND BECAME

592
00:26:26,999 --> 00:26:29,268
INTRIGUED WITH THE ETIOLOGY OF

593
00:26:29,268 --> 00:26:31,570
FAMILIAL CANCER.

594
00:26:31,570 --> 00:26:33,739
WHEN I ARRIVED AT THE NCI, I

595
00:26:33,739 --> 00:26:35,841
WORKED WITH DR. MARK GREEN, A

596
00:26:35,841 --> 00:26:38,010
MEDICAL ONCOLOGIST, WHO WAS

597
00:26:38,010 --> 00:26:39,878
INITIATING A STUDY OF FAMILIAL

598
00:26:39,878 --> 00:26:41,280
MELANOMA.

599
00:26:41,280 --> 00:26:46,785
AS AN EXPERT IN DISEASES --

600
00:26:46,785 --> 00:26:48,487
GREATLY INCREASED RISK OF

601
00:26:48,487 --> 00:26:49,721
MELANOMA, KEN WAS A VITAL

602
00:26:49,721 --> 00:26:50,956
PARTNER IN THE DESIGN,

603
00:26:50,956 --> 00:26:54,093
DEVELOPMENT AND IMPLEMENTATION

604
00:26:54,093 --> 00:26:59,031
OF THE STUDY.

605
00:26:59,031 --> 00:27:01,667
 -- IDENTIFIED SEVERAL FAMILIES

606
00:27:01,667 --> 00:27:03,735
IN WHO TWO OR MORE LIVING

607
00:27:03,735 --> 00:27:07,739
INDIVIDUALS HAD HAD MELANOMA.

608
00:27:07,739 --> 00:27:11,477
AT THE TIME IN THE MID 70s,

609
00:27:11,477 --> 00:27:15,881
THIS WAS VERY UNUSUAL.

610
00:27:15,881 --> 00:27:17,516
CLINICAL EXAMINATIONS WERE A

611
00:27:17,516 --> 00:27:18,450
VITAL COMPONENT OF THE STUDY

612
00:27:18,450 --> 00:27:19,251
FROM THE VERY BEGINNING.

613
00:27:19,251 --> 00:27:23,755
KEN WAS EXTREMELY GENEROUS IN

614
00:27:23,755 --> 00:27:26,358
GIVING US LOTS OF TIME FOR

615
00:27:26,358 --> 00:27:29,261
CLINICAL EXAMINATIONS, FOR GOING

616
00:27:29,261 --> 00:27:30,863
OUT OF TOWN TO VISIT FAMILIES

617
00:27:30,863 --> 00:27:33,465
WHO WEREN'T WILLING TO COME TO

618
00:27:33,465 --> 00:27:36,401
THE NIH, AND HE WAS ALWAYS A

619
00:27:36,401 --> 00:27:41,140
HUGE PART OF ANY INVESTIGATIVE

620
00:27:41,140 --> 00:27:48,680
WORK WE DID.

621
00:27:48,680 --> 00:27:54,920
KEN WAS ALSO EXTREMELY GENEROUS

622
00:27:54,920 --> 00:27:55,988
IN TRAVELING WITH US, BECAUSE

623
00:27:55,988 --> 00:27:56,989
LOTS OF TIMES THE FAMILIES

624
00:27:56,989 --> 00:27:58,423
WOULDN'T BE WILLING TO COME TO

625
00:27:58,423 --> 00:27:59,725
NIH SO WE'D HAVE TO GO OUT OF

626
00:27:59,725 --> 00:28:04,329
TOWN TO SEE THEM.

627
00:28:04,329 --> 00:28:05,864
IN EXAMINING THESE FAMILY

628
00:28:05,864 --> 00:28:07,733
MEMBERS, WE FOUND THOSE WHO HAD

629
00:28:07,733 --> 00:28:10,869
DEVELOPED MELANOMA HAD QUITE

630
00:28:10,869 --> 00:28:13,071
DISTINCT, RELATIVELY LARGE --

631
00:28:13,071 --> 00:28:15,607
THAT WERE IRREGULAR IN OUTLINE,

632
00:28:15,607 --> 00:28:17,876
OFTEN PREDOMINANTLY BLACK AND

633
00:28:17,876 --> 00:28:18,977
MULTICOLORED.

634
00:28:18,977 --> 00:28:23,248
THEY WERE RI ORIGINALLY DESCRIBD

635
00:28:23,248 --> 00:28:27,186
AS -- MOLES -- OF THE FIRST TWO

636
00:28:27,186 --> 00:28:28,287
FAMILIES ENROLLED IN THE STUDY.

637
00:28:28,287 --> 00:28:31,657
WHEN THE HISTOLOGY OF THE

638
00:28:31,657 --> 00:28:34,493
EXCISED LESIONS FROM MULTIPLE

639
00:28:34,493 --> 00:28:37,362
FAMILY WAS EVALUATED BY

640
00:28:37,362 --> 00:28:40,098
DR. WALLACE CLARKE, THE

641
00:28:40,098 --> 00:28:41,266
PROMINENT DERMATOPATHOLOGIST AND

642
00:28:41,266 --> 00:28:42,601
CLOSE COLLABORATOR, THE

643
00:28:42,601 --> 00:28:45,237
NOMENCLATURE EVOLVED TO

644
00:28:45,237 --> 00:28:46,972
DYSPLASTIC -- TO DESCRIBE THE

645
00:28:46,972 --> 00:28:48,307
HISTOLOGIC FEATURES.

646
00:28:48,307 --> 00:28:51,476
IN THE PARTICIPATING MELANOMA

647
00:28:51,476 --> 00:28:55,514
PRONE FAMILY, THESE UNUSUAL --

648
00:28:55,514 --> 00:28:59,551
HAVE CLINICALLY IDENTIFIED THOSE

649
00:28:59,551 --> 00:29:00,886
AT SUBSTANTIALLY INCREASED RISK

650
00:29:00,886 --> 00:29:02,187
OF MELANOMA.

651
00:29:02,187 --> 00:29:03,388
AFTER MARK GREEN LEFT THE NCI

652
00:29:03,388 --> 00:29:05,691
AND BECAME THE P.I. OF THE

653
00:29:05,691 --> 00:29:08,860
STUDY, WE WERE VERY FORTUNATE TO

654
00:29:08,860 --> 00:29:11,797
HIRE DR. LISA GOLDSTEIN AS OUR

655
00:29:11,797 --> 00:29:13,131
GENETICIST AND TO CONTINUE

656
00:29:13,131 --> 00:29:16,201
WORKING WITH KEN AND HIS

657
00:29:16,201 --> 00:29:21,873
COLLEAGUE, DR. JOHN --.

658
00:29:21,873 --> 00:29:24,476
WE COULD NOT HAVE FOUND BETTER

659
00:29:24,476 --> 00:29:27,479
PARTNERS OR ANY OTHER PARTNERS

660
00:29:27,479 --> 00:29:30,515
WHO WOULD BE AS GENEROUS,

661
00:29:30,515 --> 00:29:33,151
KNOWLEDGEABLE, CORDIAL AND

662
00:29:33,151 --> 00:29:35,520
COLLEGIAL AS KEN AND JOHN.

663
00:29:35,520 --> 00:29:40,025
 -- WORKED CLOSELY WITH KEN AND

664
00:29:40,025 --> 00:29:42,160
JOHN TO ESTABLISH THAT XERODERMA

665
00:29:42,160 --> 00:29:43,962
PIGMENTOSUM PATIENTS ALSO HAVE

666
00:29:43,962 --> 00:29:45,664
INCREASED RISK OF PREMATURE

667
00:29:45,664 --> 00:29:47,266
AGING AND EARLY DEATH.

668
00:29:47,266 --> 00:29:48,333
SEVERAL YEARS FURTHER INTO THE

669
00:29:48,333 --> 00:29:51,837
FAMILIAL STUDY, ALISA IDENTIFIED

670
00:29:51,837 --> 00:29:55,240
GENES THAT WERE IN TWO SETS OF

671
00:29:55,240 --> 00:29:56,642
FAMILIES WITH MULTIPLE

672
00:29:56,642 --> 00:30:00,479
INDIVIDUALS WITH MELANOMA, FIRST

673
00:30:00,479 --> 00:30:02,681
CDKN2A, THEN CBK4.

674
00:30:02,681 --> 00:30:04,549
THERE ARE DIFFERENCES IN CANCER

675
00:30:04,549 --> 00:30:05,717
RISK AND FAMILY IN THE TWO

676
00:30:05,717 --> 00:30:07,252
GROUPS OF FAMILIES.

677
00:30:07,252 --> 00:30:11,757
SOME FAMILIES ALSO HAVE AN

678
00:30:11,757 --> 00:30:15,594
INCREASED RISK OF DEVELOPING

679
00:30:15,594 --> 00:30:17,562
PANCREATIC CANCER, AND AS

680
00:30:17,562 --> 00:30:19,731
RECENTLY IDENTIFIED BY

681
00:30:19,731 --> 00:30:21,366
DR. MICHAEL SERGEANT, A NEXT

682
00:30:21,366 --> 00:30:23,435
GENERATION CLINICAL RESEARCHER

683
00:30:23,435 --> 00:30:28,273
STUDYING FAMILIAL MELANOMA WITH

684
00:30:28,273 --> 00:30:28,907
US.

685
00:30:28,907 --> 00:30:30,242
OTHER SMOKING-RELATED CANCERS

686
00:30:30,242 --> 00:30:32,077
ARE ALSO INCREASED.

687
00:30:32,077 --> 00:30:33,312
THERE'S STILL MUCH WORK TO BE

688
00:30:33,312 --> 00:30:35,047
DONE TO DEVELOP APPROPRIATE

689
00:30:35,047 --> 00:30:36,348
SCREENING AND POSSIBLE

690
00:30:36,348 --> 00:30:38,884
INTERVENTIONS FOR THESE DEADLY

691
00:30:38,884 --> 00:30:40,185
DISEASES.

692
00:30:40,185 --> 00:30:41,820
SO FAR WE HAVE NOT SEEN AN

693
00:30:41,820 --> 00:30:43,255
INCREASED RISK OF PANCREATIC

694
00:30:43,255 --> 00:30:46,391
CANCER OR OTHER SMOKING-RELATED

695
00:30:46,391 --> 00:30:49,094
CANCERS DEVELOPING IN

696
00:30:49,094 --> 00:30:52,197
INDIVIDUALS WITH CDK4.

697
00:30:52,197 --> 00:30:52,631
4 MUTATIONS.

698
00:30:52,631 --> 00:30:54,366
IN ALL THESE PROJECTS, KEN HAS

699
00:30:54,366 --> 00:30:58,470
BEEN AN ESSENTIAL AND INVALUABLE

700
00:30:58,470 --> 00:30:59,338
CONTRIBUTOR AND TEAMMATE.

701
00:30:59,338 --> 00:31:00,972
IT HAS BEEN A GREAT PLEASURE

702
00:31:00,972 --> 00:31:02,908
WORKING WITH BOTH KEN AND JOHN

703
00:31:02,908 --> 00:31:05,444
OVER SEVERAL DECADES, AND WE ALL

704
00:31:05,444 --> 00:31:06,545
WISH THAT JOHN WERE HERE TO

705
00:31:06,545 --> 00:31:09,715
CELEBRATE WITH US.

706
00:31:09,715 --> 00:31:11,350
I HOPE FOR A LONG, HAPPY AND

707
00:31:11,350 --> 00:31:13,652
RELAXING RETIREMENT FOR KEN,

708
00:31:13,652 --> 00:31:14,453
DORIS AND YOUR FAMILY.

709
00:31:14,453 --> 00:31:14,986
THANK YOU.

710
00:31:14,986 --> 00:31:25,163
[APPLAUSE]

711
00:31:25,163 --> 00:31:28,233
>> THANK YOU VERY MUCH,
MARGA 

712
00:31:28,233 --> 00:31:29,401
MARGARET.

713
00:31:29,401 --> 00:31:37,042
SO NEXT, I WOULD LIKE TO INVITE

714
00:31:37,042 --> 00:31:37,709
SIKANDAR AND JEFF.

715
00:31:37,709 --> 00:31:38,910
WHEN KEN ANNOUNCED HE WAS GOING

716
00:31:38,910 --> 00:31:40,545
TO RETIRE, I ASKED HIM, WHAT ARE

717
00:31:40,545 --> 00:31:41,113
YOUR PLANS?

718
00:31:41,113 --> 00:31:42,414
AND HE SAID, I'M GOING TO SPEND

719
00:31:42,414 --> 00:31:45,917
MORE TIME WITH MY FAMILY.

720
00:31:45,917 --> 00:31:47,786
SO HE SHOWED A PICTURE OF THE

721
00:31:47,786 --> 00:31:49,087
FAMILY AND IT WAS FANTASTIC AND

722
00:31:49,087 --> 00:31:50,522
HE WAS SAYING THIS IS GREAT.

723
00:31:50,522 --> 00:31:52,924
THEN I SAW HIM AGAIN A FEW WEEKS

724
00:31:52,924 --> 00:31:54,893
LATER, SAW HIM AGAIN A FEW WEEKS

725
00:31:54,893 --> 00:31:56,294
LATER, AND I WASN'T SURE WHAT'S

726
00:31:56,294 --> 00:31:58,597
GOING ON BECAUSE WAS GOING

727
00:31:58,597 --> 00:31:59,331
ACTUALLY GOING TO SPEND TIME

728
00:31:59,331 --> 00:32:00,799
WITH THE FAMILY OR NOT?

729
00:32:00,799 --> 00:32:02,534
THEN I REALIZED, LCBG IS HIS

730
00:32:02,534 --> 00:32:04,503
FAMILY TOO.

731
00:32:04,503 --> 00:32:07,139
SO WE INVITE THE TWO REMAINING

732
00:32:07,139 --> 00:32:09,541
PEOPLE IN HIS GROUP HERE,

733
00:32:09,541 --> 00:32:11,643
MEMBERS OF KEN KRAEMER'S FAMILY.

734
00:32:11,643 --> 00:32:19,184
[APPLAUSE]

735
00:32:19,184 --> 00:32:20,919
>> HELLO, EVERYONE.

736
00:32:20,919 --> 00:32:24,856
TODAY WE ARE GATHERED HERE TO

737
00:32:24,856 --> 00:32:26,825
CELEBRATE AND HONOR THE

738
00:32:26,825 --> 00:32:29,227
RETIREMENT OF DR. KRAEMER.

739
00:32:29,227 --> 00:32:32,831
AT THIS MOMENT, I FIND MYSELF

740
00:32:32,831 --> 00:32:35,367
REFLECTING ON A JOURNEY THAT

741
00:32:35,367 --> 00:32:37,736
SPANS ALMOST THREE DECADES, A

742
00:32:37,736 --> 00:32:42,574
JOURNEY FILLED WITH LEARNING,

743
00:32:42,574 --> 00:32:44,876
LAUGHING, AND AN EXTRAORDINARY

744
00:32:44,876 --> 00:32:47,279
BOND THAT EXTENDS FAR BEYOND THE

745
00:32:47,279 --> 00:32:49,681
BONDS OF OUR LIVES.

746
00:32:49,681 --> 00:32:53,051
DR. KRAEMER, YOU HAVE BEEN MORE

747
00:32:53,051 --> 00:32:57,556
THAN JUST A BOSS OR A COLLEAGUE.

748
00:32:57,556 --> 00:33:02,027
YOU ARE FAMILY.

749
00:33:02,027 --> 00:33:03,562
WHEN I MOVED FROM OHIO TO

750
00:33:03,562 --> 00:33:06,298
MARYLAND WITH A 3 WEEK OLD BABY,

751
00:33:06,298 --> 00:33:08,900
YOU WERE THERE TO PICK US UP

752
00:33:08,900 --> 00:33:14,739
FROM THE AIRPORT.

753
00:33:14,739 --> 00:33:16,942
THAT GESTURE OF KINDNESS WAS

754
00:33:16,942 --> 00:33:18,643
JUST A GLIMPSE OF TREMENDOUS

755
00:33:18,643 --> 00:33:20,479
SUPPORT YOU HAVE SHOWN TO US

756
00:33:20,479 --> 00:33:23,915
OVER THE YEARS.

757
00:33:23,915 --> 00:33:25,784
YOU HELPED US SETTLE IN USING

758
00:33:25,784 --> 00:33:28,587
OUR TRANSITION INTO A NEW STATE

759
00:33:28,587 --> 00:33:34,626
AND A NEW PHASE OF OUR LIVES.

760
00:33:34,626 --> 00:33:38,597
OUR FAMILY GREW CLOSE, SHARING

761
00:33:38,597 --> 00:33:40,732
COUNTLESS JOYOUS OCCASIONS.

762
00:33:40,732 --> 00:33:45,136
FROM HOUSE PARTIES TO INTERFAITH

763
00:33:45,136 --> 00:33:46,905
EVENTS, EVERY MOMENT SPENT WITH

764
00:33:46,905 --> 00:33:50,375
YOUR FAMILY INCLUDING -- AND

765
00:33:50,375 --> 00:33:56,181
YOUR LOVING CHILDREN WAS A

766
00:33:56,181 --> 00:34:04,723
BLESSING.

767
00:34:04,723 --> 00:34:06,625
THE PARTIES ARE ETCHED IN MY

768
00:34:06,625 --> 00:34:08,093
CHILDREN'S MEMORY.

769
00:34:08,093 --> 00:34:11,162
ESPECIALLY THE MOMENT WHEN

770
00:34:11,162 --> 00:34:15,100
DR. KRAEMER DRESSED AS SANTA

771
00:34:15,100 --> 00:34:19,471
CLAUS, A TRADITION THAT

772
00:34:19,471 --> 00:34:22,541
CONTINUES TO THIS DATE.

773
00:34:22,541 --> 00:34:24,643
DORIS, YOU HAVE BEEN AN INTEGRAL

774
00:34:24,643 --> 00:34:30,081
PART OF OUR EXTENDED LIFE

775
00:34:30,081 --> 00:34:30,515
FAMILY.

776
00:34:30,515 --> 00:34:32,050
YOUR PARTNERSHIP WITH

777
00:34:32,050 --> 00:34:33,018
DR. KRAEMER IS AN INSPIRATION

778
00:34:33,018 --> 00:34:39,724
FOR ALL OF US.

779
00:34:39,724 --> 00:34:42,060
DR. KRAEMER, YOUR MENTORSHIP HAS

780
00:34:42,060 --> 00:34:42,894
BEEN A GUIDING LIGHT IN MY

781
00:34:42,894 --> 00:34:43,228
CAREER.

782
00:34:43,228 --> 00:34:46,831
YOU HAVE TAUGHT ME THE ESSENTIAL

783
00:34:46,831 --> 00:34:47,799
COMPASSIONATE LEADERSHIP AND THE

784
00:34:47,799 --> 00:34:52,504
IMPORTANCE OF NURTURING A TEAM

785
00:34:52,504 --> 00:34:53,705
THAT LOOKS LIKE A FAMILY.

786
00:34:53,705 --> 00:34:57,309
THE MOMENT YOU HAVE CREATED IN

787
00:34:57,309 --> 00:35:02,914
THE LAB ALONGSIDE THE LATE DR

788
00:35:02,914 --> 00:35:05,850
DR. -- ALL PREVIOUS LAB MEMBERS

789
00:35:05,850 --> 00:35:10,655
IS INCREDIBLE.

790
00:35:10,655 --> 00:35:13,525
AT THIS MOMENT,  I MISS DR. --

791
00:35:13,525 --> 00:35:15,160
WHO WAS A COMPASSIONATE

792
00:35:15,160 --> 00:35:19,397
CLINICIAN AND AN AMAZING --

793
00:35:19,397 --> 00:35:21,399
THERE IS PERSONAL RELATIONSHIP

794
00:35:21,399 --> 00:35:27,405
TO OUR PATIENT IN CLINICAL

795
00:35:27,405 --> 00:35:28,506
DISCOVERIES.

796
00:35:28,506 --> 00:35:32,077
MY CHILDREN HAVE FOND MEMORIES

797
00:35:32,077 --> 00:35:33,945
OF CHRISTMAS PARTIES AND PLAYING

798
00:35:33,945 --> 00:35:40,852
WITH HER LOVING DOG.

799
00:35:40,852 --> 00:35:44,356
DR. KRAEMER, YOUR DEDICATION TO

800
00:35:44,356 --> 00:35:51,029
MENTORING A DIVERSE TEAM --

801
00:35:51,029 --> 00:35:56,601
SPEAKS VOLUMES ABOUT YOU.

802
00:35:56,601 --> 00:35:59,137
YOUR CONCERN OF OUR WELL-BEING

803
00:35:59,137 --> 00:36:01,740
LIKE WHEN YOU CHECKED IN ON ME

804
00:36:01,740 --> 00:36:04,042
DURING MY HEALTH ISSUES SHOWS

805
00:36:04,042 --> 00:36:08,980
THE DEPTH OF YOUR CARE.

806
00:36:08,980 --> 00:36:13,785
AS WE GATHER TODAY, HERE I AM

807
00:36:13,785 --> 00:36:17,489
OVERWHELMED WITH MIXED EMOTIONS.

808
00:36:17,489 --> 00:36:23,528
IT IS A BITTERSWEET MOMENT,

809
00:36:23,528 --> 00:36:25,130
CHERISHING RELATIONSHIP AND

810
00:36:25,130 --> 00:36:26,464
MEMORIES THAT WILL LAST A

811
00:36:26,464 --> 00:36:29,768
LIFETIME.

812
00:36:29,768 --> 00:36:31,036
DR. KRAEMER, YOU HOLD A SPECIAL

813
00:36:31,036 --> 00:36:33,471
PLACE IN MY HEART.

814
00:36:33,471 --> 00:36:36,508
I LOOK FORWARD TO CONTINUING

815
00:36:36,508 --> 00:36:38,610
THIS RELATIONSHIP.

816
00:36:38,610 --> 00:36:41,880
IN CLOSING, I WANT TO EXPRESS MY

817
00:36:41,880 --> 00:36:45,817
DEEPEST GRATITUDE.

818
00:36:45,817 --> 00:36:48,787
YOUR IMPACT ON MY LIFE BOTH

819
00:36:48,787 --> 00:36:53,158
PROFESSIONALLY AND PERSONALLY.

820
00:36:53,158 --> 00:36:55,226
WE MAY BE CLOSING THIS CHAPTER,

821
00:36:55,226 --> 00:36:57,195
BUT THE LESSON AND MEMORIES YOU

822
00:36:57,195 --> 00:37:00,699
HAVE IMPARTED ON US WILL

823
00:37:00,699 --> 00:37:03,435
CONTINUE TO INSPIRE AND GUIDE US

824
00:37:03,435 --> 00:37:03,601
ALL.

825
00:37:03,601 --> 00:37:09,007
THANK YOU, DR. KRAEMER, FOR

826
00:37:09,007 --> 00:37:09,307
EVERYTHING.

827
00:37:09,307 --> 00:37:16,247
[APPLAUSE]

828
00:37:16,247 --> 00:37:17,415
>> HI, EVERYONE.

829
00:37:17,415 --> 00:37:18,750
MY NAME IS JEFFREY.

830
00:37:18,750 --> 00:37:20,385
I HAVE THE INCREDIBLE HONOR OF

831
00:37:20,385 --> 00:37:23,321
BEING DR. KRAEMER'S LAST NIH

832
00:37:23,321 --> 00:37:25,290
POSTDOC HE FORMALLY TRAINED.

833
00:37:25,290 --> 00:37:27,492
TODAY I WANT TO SHARE A BRIEF

834
00:37:27,492 --> 00:37:29,461
STORY THAT REALLY ENCAPSULATES

835
00:37:29,461 --> 00:37:31,429
THE IMPACT DR. KRAEMER HAD ON

836
00:37:31,429 --> 00:37:31,863
ME.

837
00:37:31,863 --> 00:37:34,599
SO LAST WEEK, I HAD MY FIRST

838
00:37:34,599 --> 00:37:36,801
MEDICAL SCHOOL INTERVIEW, AND I

839
00:37:36,801 --> 00:37:38,770
WAS CONFIDENT, I WAS READY, I

840
00:37:38,770 --> 00:37:40,405
WAS READY FOR ANY QUESTION THEY

841
00:37:40,405 --> 00:37:41,272
COULD THROW AT ME.

842
00:37:41,272 --> 00:37:43,141
BUT THEN CAME THE UNEXPECTED.

843
00:37:43,141 --> 00:37:45,677
WHO IS YOUR BIGGEST ROLE MODEL?

844
00:37:45,677 --> 00:37:48,913
I SAT THERE FOR A FEW SECONDS,

845
00:37:48,913 --> 00:37:49,180
THINKING.

846
00:37:49,180 --> 00:37:50,682
AND THE FIRST PERSON THAT CAME

847
00:37:50,682 --> 00:37:52,884
TO MY MIND WAS DR. KRAEMER.

848
00:37:52,884 --> 00:37:56,254
I SAID, DR. KRAEMER IS A

849
00:37:56,254 --> 00:37:58,323
BRILLIANT RESEARCH PHYSICIAN.

850
00:37:58,323 --> 00:38:00,525
HE'S DEDICATED TO HIS

851
00:38:00,525 --> 00:38:02,160
COLLEAGUES, FAMILY AND PATIENTS,

852
00:38:02,160 --> 00:38:05,230
AND OVERALL, HE'S A SUPER COOL

853
00:38:05,230 --> 00:38:05,997
AND CHILL PERSON.

854
00:38:05,997 --> 00:38:06,998
HE'S THE TYPE OF DOCTOR THAT I

855
00:38:06,998 --> 00:38:08,500
WANT TO BE.

856
00:38:08,500 --> 00:38:10,034
AND AS A MENTOR, HE WENT ABOVE

857
00:38:10,034 --> 00:38:11,803
AND BEYOND.

858
00:38:11,803 --> 00:38:13,671
HE AND DORIS WELCOMED ME INTO

859
00:38:13,671 --> 00:38:16,407
THEIR HOME, INCLUDED ME IN

860
00:38:16,407 --> 00:38:17,709
FAMILY OUTINGS AND MADE MY

861
00:38:17,709 --> 00:38:18,810
TRANSITION TO MARYLAND FEEL LIKE

862
00:38:18,810 --> 00:38:19,577
HOME.

863
00:38:19,577 --> 00:38:21,746
SO DR. KRAEMER, THANK YOU FOR

864
00:38:21,746 --> 00:38:23,381
BEING MORE THAN JUST A MENTOR.

865
00:38:23,381 --> 00:38:24,916
THANK YOU FOR BEING MY ROLE

866
00:38:24,916 --> 00:38:27,752
MODEL, AND MAKING MY NIH

867
00:38:27,752 --> 00:38:28,553
EXPERIENCE UNFORGETTABLE.

868
00:38:28,553 --> 00:38:30,822
AND SO WITH THAT, CHEERS TO YOUR

869
00:38:30,822 --> 00:38:33,124
WELL-DESERVED RETIREMENT, AND

870
00:38:33,124 --> 00:38:35,093
MAY YOU CONTINUE TO INSPIRE MORE

871
00:38:35,093 --> 00:38:35,426
LIKE ME.

872
00:38:35,426 --> 00:38:35,860
THANK YOU.

873
00:38:35,860 --> 00:38:44,002
[APPLAUSE]

874
00:38:44,002 --> 00:38:46,704
>> THANK YOU VERY MUCH.

875
00:38:46,704 --> 00:38:48,807
NEXT I WOULD LIKE TO INVITE

876
00:38:48,807 --> 00:38:54,279
DEBBY.

877
00:38:54,279 --> 00:38:56,414
CURRENT LAB MEMBERS BE READY

878
00:38:56,414 --> 00:38:59,083
BECAUSE I THINK YOU HAVE A TASK

879
00:38:59,083 --> 00:39:01,920
AFTER DEBBY.

880
00:39:01,920 --> 00:39:06,391
BEFORE YOU START, LET ME GIVE

881
00:39:06,391 --> 00:39:12,564
YOU -- [INAUDIBLE]

882
00:39:12,564 --> 00:39:22,740
[APPLAUSE]

883
00:39:24,642 --> 00:39:25,877
DEBBY IS GOING TO SPEAK FOR

884
00:39:25,877 --> 00:39:27,745
HERSELF BUT SHE IS PRACTICALLY

885
00:39:27,745 --> 00:39:29,147
THE RIGHT HAND FOR KEN IN

886
00:39:29,147 --> 00:39:30,148
ORGANIZING ALL THE COMPLEX

887
00:39:30,148 --> 00:39:31,549
FAMILIES IN THE STUDIES THAT

888
00:39:31,549 --> 00:39:33,351
THEY DO SO THEY MAKE A FANTASTIC

889
00:39:33,351 --> 00:39:40,458
TEAM.

890
00:39:40,458 --> 00:39:42,493
>> OKAY, I'M GOING TO TRY
NOT TO

891
00:39:42,493 --> 00:39:48,199
CRY.

892
00:39:48,199 --> 00:39:49,834
SO DR. KRAEMER, I AM SURE THAT

893
00:39:49,834 --> 00:39:52,136
THERE IS NOTHING MORE THAT I CAN

894
00:39:52,136 --> 00:39:54,539
SAY ABOUT YOUR REMARKABLE CAREER

895
00:39:54,539 --> 00:39:56,174
THAT HASN'T ALREADY BEEN SAID OR

896
00:39:56,174 --> 00:39:58,676
WILL BE SAID ABOUT THE NEXT HOUR

897
00:39:58,676 --> 00:39:59,911
OR SO.

898
00:39:59,911 --> 00:40:02,947
YOU ARE A DEDICATED PHYSICIAN, A

899
00:40:02,947 --> 00:40:06,551
BRILLIANT SCIENTIST, AND AN

900
00:40:06,551 --> 00:40:07,552
OUTSTANDING MENTOR.

901
00:40:07,552 --> 00:40:09,287
AND YOU'RE JUST AN ALL AROUND

902
00:40:09,287 --> 00:40:10,288
GOOD GUY.

903
00:40:10,288 --> 00:40:12,323
SO I THOUGHT I'D CATCH YOU UP ON

904
00:40:12,323 --> 00:40:16,961
ONE OF OUR PATIENTS.

905
00:40:16,961 --> 00:40:17,929
YOU'VE KNOWN ABOUT HER FOR A

906
00:40:17,929 --> 00:40:20,465
LONG TIME BUT IT WASN'T UNTIL

907
00:40:20,465 --> 00:40:26,137
ABOUT 19 -- OR I'M SORRY -- 2010

908
00:40:26,137 --> 00:40:27,472
THAT WE WERE FINALLY ABLE TO SEE

909
00:40:27,472 --> 00:40:28,973
HER IN OUR CLINIC.

910
00:40:28,973 --> 00:40:30,942
THE PATIENT HAD BEEN DIAGNOSED

911
00:40:30,942 --> 00:40:32,477
WITH XP WHEN SHE WAS A VERY

912
00:40:32,477 --> 00:40:34,445
YOUNG CHILD, BUT SHE HAD VERY

913
00:40:34,445 --> 00:40:36,214
POOR UV PROTECTION, AND BY THE

914
00:40:36,214 --> 00:40:38,716
TIME SHE WAS 7 YEARS OLD, SHE

915
00:40:38,716 --> 00:40:41,219
HAD SO MANY SKIN CANCERS ON HER

916
00:40:41,219 --> 00:40:42,654
FACE THAT SHE HAD TO HAVE ALL

917
00:40:42,654 --> 00:40:45,189
THE SKIN ON HER FACE REMOVED AND

918
00:40:45,189 --> 00:40:51,996
THEN REPLACED.

919
00:40:51,996 --> 00:40:52,630
UNFORTUNATELY THE PATIENT

920
00:40:52,630 --> 00:40:54,399
CONTINUED TO HAVE POOR UV

921
00:40:54,399 --> 00:40:56,801
PROTECTION, AND BY THE TIME WE

922
00:40:56,801 --> 00:40:59,904
SAW HER, SHE'D HAD OVER A

923
00:40:59,904 --> 00:41:00,738
THOUSAND SKIN CANCERS.

924
00:41:00,738 --> 00:41:02,173
SO THINK ABOUT THAT, A THOUSAND

925
00:41:02,173 --> 00:41:06,411
SKIN CANCERS.

926
00:41:06,411 --> 00:41:08,179
DR. KRAEMER, THE LONG ARM OF

927
00:41:08,179 --> 00:41:10,682
YOUR MENTORSHIP REACHES OUT IN

928
00:41:10,682 --> 00:41:16,721
MIMYSTERIOUS WAYS AND ONE OF OUR

929
00:41:16,721 --> 00:41:17,588
STUDENTS BECAME A DETERMINE TOLL

930
00:41:17,588 --> 00:41:19,691
STUDENT AND THEN STAYED ON AS A

931
00:41:19,691 --> 00:41:20,858
FACULTY MEMBER AT THE MEDICAL

932
00:41:20,858 --> 00:41:21,526
CENTER WHERE THIS PATIENT WAS

933
00:41:21,526 --> 00:41:22,827
GETTING TREATED.

934
00:41:22,827 --> 00:41:24,796
OVER A SERIES OF VISITS WITH

935
00:41:24,796 --> 00:41:25,997
THAT PHYSICIAN AND THEN COMING

936
00:41:25,997 --> 00:41:31,936
HERE TO THE NIH, FINALLY, YOU

937
00:41:31,936 --> 00:41:35,540
AND DR. GIOVANNA PUSHED THE

938
00:41:35,540 --> 00:41:37,308
PATIENT TO USE BETTER UV

939
00:41:37,308 --> 00:41:37,742
PROTECTION.

940
00:41:37,742 --> 00:41:43,081
AND ME AS NOT AS GENTLE ABOUT IT

941
00:41:43,081 --> 00:41:44,749
AND I PUSHED A LOT HARDER.

942
00:41:44,749 --> 00:41:46,384
IN COLLABORATION WITH HER

943
00:41:46,384 --> 00:41:48,119
WONDERFUL LOCAL PHYSICIAN, YOU

944
00:41:48,119 --> 00:41:49,554
AND DR. D ENCOURAGED THE PATIENT

945
00:41:49,554 --> 00:41:53,257
TO TAKE BETTER CARE OF HERSELF.

946
00:41:53,257 --> 00:41:54,492
OVER THE COURSE OF SEVERAL

947
00:41:54,492 --> 00:41:56,561
VISITS WITH US AT THE NIH, WE

948
00:41:56,561 --> 00:41:59,397
NOTICED A GRADUAL CHANGE IN THE

949
00:41:59,397 --> 00:42:00,798
PATIENT'S UV PROTECTION

950
00:42:00,798 --> 00:42:01,466
BEHAVIOR.

951
00:42:01,466 --> 00:42:03,668
AT THE END OF HER LAST VISIT

952
00:42:03,668 --> 00:42:08,940
WITH US, THE PARITY WAS GETTING-

953
00:42:08,940 --> 00:42:11,642
THE PATIENT WAS GETTING

954
00:42:11,642 --> 00:42:14,712
NOTICEABLY FEWER SQUAMOUS CELL

955
00:42:14,712 --> 00:42:15,146
CARCINOMAS.

956
00:42:15,146 --> 00:42:16,681
THE BEST WAY TO KEEP IN TOUCH

957
00:42:16,681 --> 00:42:19,584
WITH ALL OF THE PATIENTS, AND

958
00:42:19,584 --> 00:42:22,920
THREE WEEKS AGO, SHE POSTED --

959
00:42:22,920 --> 00:42:24,322
JUST HAD A DERMATOLOGIST

960
00:42:24,322 --> 00:42:24,789
APPOINTMENT.

961
00:42:24,789 --> 00:42:26,958
NO SKIN CANCERS.

962
00:42:26,958 --> 00:42:28,593
DR. KRAEMER, THIS IS THE FIRST

963
00:42:28,593 --> 00:42:30,795
TIME IN OVER 30 YEARS THE

964
00:42:30,795 --> 00:42:32,430
PATIENT HAD NOT HAD A SKIN

965
00:42:32,430 --> 00:42:34,732
CANCER DIAGNOSED AT A

966
00:42:34,732 --> 00:42:36,567
DERMATOLOGY VISIT.

967
00:42:36,567 --> 00:42:38,903
ABOVE EVERYTHING ELSE THAT

968
00:42:38,903 --> 00:42:40,071
DR. KRAEMER HAS EVER DONE,

969
00:42:40,071 --> 00:42:41,939
MAKING SURE THAT OUR PATIENTS

970
00:42:41,939 --> 00:42:44,909
GET REALLY GOOD CARE, THAT'S THE

971
00:42:44,909 --> 00:42:46,644
LEGACY THAT I HOPE YOU ALL

972
00:42:46,644 --> 00:42:49,414
REMEMBER.

973
00:42:49,414 --> 00:42:50,148
DR. KRAEMER, THANK YOU SO MUCH

974
00:42:50,148 --> 00:42:53,317
FOR RECRUITING ME FROM HAWAII.

975
00:42:53,317 --> 00:42:55,086
I'VE JUST ENJOYED THE LAST 20

976
00:42:55,086 --> 00:42:58,022
YEARS WORKING WITH YOU.

977
00:42:58,022 --> 00:42:59,290
YOU JUST TAUGHT ME SO MUCH, AND

978
00:42:59,290 --> 00:43:00,892
THANK YOU, THANK YOU, THANK YOU.

979
00:43:00,892 --> 00:43:11,069
[APPLAUSE]

980
00:43:15,706 --> 00:43:17,608
>> CAN I INVITE ALL THE
CURRENT

981
00:43:17,608 --> 00:43:20,244
MEMBERS OF DR. KRAEMER'S LAB TO

982
00:43:20,244 --> 00:43:30,555
THE FRONT, PLEASE?

983
00:44:08,359 --> 00:44:15,700
[APPLAUSE]

984
00:44:15,700 --> 00:44:18,636
>> SO WHAT THEY PRESENTED
IS A

985
00:44:18,636 --> 00:44:20,938
PHOTO ALBUM OF A COLLECTION OF

986
00:44:20,938 --> 00:44:21,939
PHOTOGRAPHS FROM HIS EARLY DAYS

987
00:44:21,939 --> 00:44:25,109
AT NIH ALL THE WAY TO NOW.

988
00:44:25,109 --> 00:44:26,310
IT'S VERY BEAUTIFUL WORK.

989
00:44:26,310 --> 00:44:29,680
GOOD JOB.

990
00:44:29,680 --> 00:44:32,984
NEXT I WOULD LIKE TO INVITE MARK

991
00:44:32,984 --> 00:44:42,059
UDEY TO SAY A FEW WORDS.

992
00:44:42,059 --> 00:44:43,127
>> WELL, I'M A LITTLE BIT

993
00:44:43,127 --> 00:44:44,562
SURPRISED TO BE HERE TODAY.

994
00:44:44,562 --> 00:44:45,763
IN LARGE PART BECAUSE A NUMBER

995
00:44:45,763 --> 00:44:49,267
OF YEARS AGO, I'M QUITE CERTAIN

996
00:44:49,267 --> 00:44:51,569
THAT KEN'S WIFE DORIS TOLD MY

997
00:44:51,569 --> 00:44:54,205
WIFE DEBORAH THAT KEN WOULD

998
00:44:54,205 --> 00:45:00,211
NEVER RETIRE.

999
00:45:00,211 --> 00:45:03,814
I'M GLAD TO SEE THAT SOME SANITY

1000
00:45:03,814 --> 00:45:07,952
HAS PREVAILED.

1001
00:45:07,952 --> 00:45:09,187
I FIRST MET KEN IN THE EARLY

1002
00:45:09,187 --> 00:45:11,289
80s WHEN I WAS A DERMATOLOGY

1003
00:45:11,289 --> 00:45:12,490
RESIDENT AT WASHINGTON

1004
00:45:12,490 --> 00:45:13,090
UNIVERSITY SCHOOL OF MEDICINE.

1005
00:45:13,090 --> 00:45:14,325
I DIDN'T KNOW ANYTHING ABOUT KEN

1006
00:45:14,325 --> 00:45:15,660
PRIOR TO THAT TIME AND DIDN'T

1007
00:45:15,660 --> 00:45:17,395
KNOW ANYTHING ABOUT THE NIH

1008
00:45:17,395 --> 00:45:18,829
INTRAMURAL PROGRAM, KNEW VERY

1009
00:45:18,829 --> 00:45:23,868
LITTLE ABOUT XP BUT I DID

1010
00:45:23,868 --> 00:45:26,504
KNOW -- HE HAD ONLY RESPECT FOR

1011
00:45:26,504 --> 00:45:30,341
SERIOUS PEOPLE BECAUSE HE

1012
00:45:30,341 --> 00:45:31,576
INVITED KEN TO BE A VISITING

1013
00:45:31,576 --> 00:45:31,842
PROFESSOR.

1014
00:45:31,842 --> 00:45:37,348
I GOT TO KNOW KENMORE OVER MY

1015
00:45:37,348 --> 00:45:40,418
TENURE, 2009 TO 2017, AND WORKED

1016
00:45:40,418 --> 00:45:43,054
WITH KEN IN A NUMBER OF WAYS

1017
00:45:43,054 --> 00:45:43,554
FREQUENTLY.

1018
00:45:43,554 --> 00:45:45,990
KEN WAS ALWAYS AT AN

1019
00:45:45,990 --> 00:45:49,060
ADMINISTRATIVE DISTANCE FROM THE

1020
00:45:49,060 --> 00:45:49,927
BRANCH, BUT HE ALWAYS MADE

1021
00:45:49,927 --> 00:45:51,229
CERTAIN THAT HE AND HIS

1022
00:45:51,229 --> 00:45:52,296
COLLEAGUES AND HIS CO-WORKERS

1023
00:45:52,296 --> 00:45:55,166
AND TRAINEES WERE AN INTEGRAL

1024
00:45:55,166 --> 00:45:57,802
PART OF THE DERMATOLOGY BRANCH

1025
00:45:57,802 --> 00:45:59,136
ACTIVITIES AND AN ACTIVE

1026
00:45:59,136 --> 00:46:00,238
PARTICIPANT AND I REALLY, REALLY

1027
00:46:00,238 --> 00:46:01,772
APPRECIATE THAT, KEN.

1028
00:46:01,772 --> 00:46:03,207
A WORD I WOULD USE TO DESCRIBE

1029
00:46:03,207 --> 00:46:04,275
KEN IS COMMITMENT.

1030
00:46:04,275 --> 00:46:05,610
KEN IS ONE OF THE MOST COMMITTED

1031
00:46:05,610 --> 00:46:06,611
PEOPLE I'VE EVER MET.

1032
00:46:06,611 --> 00:46:09,347
HE'S COMMITTED TO HIS PATIENTS,

1033
00:46:09,347 --> 00:46:10,648
COMMITTED TO HIS WORK, COMMITTED

1034
00:46:10,648 --> 00:46:12,183
TO HIS FAMILIMENT HE'S ONLY BEEN

1035
00:46:12,183 --> 00:46:15,152
ABLE TO ACCOMPLISH WHAT HE'S

1036
00:46:15,152 --> 00:46:15,920
ACCOMPLISHED -- AND I THINK

1037
00:46:15,920 --> 00:46:19,190
THAT'S AN ADMIRABLE

1038
00:46:19,190 --> 00:46:20,725
CHARACTERISTIC AND HOPE TO

1039
00:46:20,725 --> 00:46:22,260
EMULATE IT GOING FORWARD.

1040
00:46:22,260 --> 00:46:25,630
I ALSO WANT TO THANK YOU FOR ALL

1041
00:46:25,630 --> 00:46:27,632
THAT YOU'VE DONE TO SUPPORT ME

1042
00:46:27,632 --> 00:46:30,368
OVER THE YEARS SMS.

1043
00:46:30,368 --> 00:46:33,237
I WISH YOU A LONG LIFE, GOOD

1044
00:46:33,237 --> 00:46:34,772
HEALTH AND MUCH HAPPINESS.

1045
00:46:34,772 --> 00:46:37,842
YON GRCONGRATULATIONS, KEN.

1046
00:46:37,842 --> 00:46:43,648
[APPLAUSE]

1047
00:46:43,648 --> 00:46:44,949
>> THANK YOU, MARK.

1048
00:46:44,949 --> 00:46:49,120
I WOULD LIKE TO INVITE MICHELE

1049
00:46:49,120 --> 00:46:57,995
EVANS.

1050
00:46:57,995 --> 00:46:59,196
>> THANK YOU, KEN.

1051
00:46:59,196 --> 00:47:00,831
THANK YOU FOR MY CAREER HERE AT

1052
00:47:00,831 --> 00:47:02,099
NIH.

1053
00:47:02,099 --> 00:47:11,342
I MET KEN WHEN I JOINED VIL

1054
00:47:11,342 --> 00:47:14,979
BOHR'S LAB, AND AS YOU WILL

1055
00:47:14,979 --> 00:47:17,415
HEARD VIL AND KEN WERE CONNECTED

1056
00:47:17,415 --> 00:47:19,116
AT THE HIP.

1057
00:47:19,116 --> 00:47:20,451
HE MENTORED ME AS WELL, HELPING

1058
00:47:20,451 --> 00:47:22,953
ME THROUGH MY FIRST BSC, BY THAT

1059
00:47:22,953 --> 00:47:24,155
TIME WE HAD MOVED UP TO

1060
00:47:24,155 --> 00:47:24,522
BALTIMORE.

1061
00:47:24,522 --> 00:47:25,790
HE CAME UP TO BALTIMORE.

1062
00:47:25,790 --> 00:47:27,358
HE WENT THROUGH MY SLIDES WITH

1063
00:47:27,358 --> 00:47:27,758
ME.

1064
00:47:27,758 --> 00:47:30,328
HE REALLY SHOWED ME WHAT WAS A

1065
00:47:30,328 --> 00:47:31,962
GOOD POWERPOINT SLIDE AND WHAT

1066
00:47:31,962 --> 00:47:33,397
WASN'T A GOOD POWERPOINT SLIDE,

1067
00:47:33,397 --> 00:47:35,166
AND AT THAT TIME, GETTING ON THE

1068
00:47:35,166 --> 00:47:38,002
TENURE TRACK, YOU HAD TO HAVE A

1069
00:47:38,002 --> 00:47:39,103
SUCCESSFUL BMC.

1070
00:47:39,103 --> 00:47:40,304
THERE WASN'T THIS ADVERTISEMENT

1071
00:47:40,304 --> 00:47:41,739
BECAUSE THERE REALLY WAS NOT A

1072
00:47:41,739 --> 00:47:43,708
TRUE TENURE TRACK YET.

1073
00:47:43,708 --> 00:47:47,445
AND SO JUST MAKING THAT JUMP,

1074
00:47:47,445 --> 00:47:49,980
KEN WAS THERE WORKING WITH VIL

1075
00:47:49,980 --> 00:47:54,085
TO MAKE THAT HAPPEN.

1076
00:47:54,085 --> 00:47:55,653
BUT MOST IMPORTANTLY, I THINK

1077
00:47:55,653 --> 00:47:58,823
KEN INVESTED IN ME BECAUSE OF

1078
00:47:58,823 --> 00:48:00,691
HIS DEEP COMMITMENT TO EQUITY

1079
00:48:00,691 --> 00:48:03,094
AND DIVERSITY AND RECOGNIZING

1080
00:48:03,094 --> 00:48:04,295
THAT EVERYONE SHOULD HAVE AN

1081
00:48:04,295 --> 00:48:05,963
OPPORTUNITY TO PURSUE A CAREER

1082
00:48:05,963 --> 00:48:08,265
HERE AT NIH.

1083
00:48:08,265 --> 00:48:11,736
HE SUPPORTED ME IN EVERYTHING

1084
00:48:11,736 --> 00:48:13,938
THAT I HAVE EVER DONE HERE AT

1085
00:48:13,938 --> 00:48:17,942
NIH, PROVIDING A RECOMMENDATION

1086
00:48:17,942 --> 00:48:19,443
OR JUST CHECK IN TO SEE HOW

1087
00:48:19,443 --> 00:48:20,978
THINGS WERE GOING.

1088
00:48:20,978 --> 00:48:22,913
GOING TO INTERNATIONAL

1089
00:48:22,913 --> 00:48:25,683
SCIENTIFIC MEETINGS IS NOT EASY,

1090
00:48:25,683 --> 00:48:30,921
WAS NOT EASY AS MAYBE THE ONLY

1091
00:48:30,921 --> 00:48:33,023
BLACK PERSON, MAYBE THE ONLY

1092
00:48:33,023 --> 00:48:33,791
BLACK WOMAN THERE AT THE

1093
00:48:33,791 --> 00:48:34,258
CONFERENCE.

1094
00:48:34,258 --> 00:48:39,463
BUT KEN AND DORIS, DORIS WOULD

1095
00:48:39,463 --> 00:48:40,498
SAY, NOBODY'S TALKING TO

1096
00:48:40,498 --> 00:48:40,765
MICHELLE.

1097
00:48:40,765 --> 00:48:42,333
LET ME GO OVER THERE AND TALK TO

1098
00:48:42,333 --> 00:48:42,900
MICHELLE.

1099
00:48:42,900 --> 00:48:48,339
LET ME GO SEE MICHELE AT HER

1100
00:48:48,339 --> 00:48:48,906
POSTER.

1101
00:48:48,906 --> 00:48:50,107
THEY MADE SURE THAT I FELT

1102
00:48:50,107 --> 00:48:52,176
COMFORTABLE, THAT I FELT

1103
00:48:52,176 --> 00:48:52,943
INCLUDED.

1104
00:48:52,943 --> 00:48:54,478
THIS IS BACK IN THE 1990s.

1105
00:48:54,478 --> 00:48:58,115
NO ONE WAS TALKING ABOUT

1106
00:48:58,115 --> 00:48:59,083
DIVERSITY, EQUITY AND INCLUSION

1107
00:48:59,083 --> 00:48:59,750
AT THAT TIME.

1108
00:48:59,750 --> 00:49:02,720
THEY DIDN'T NEED TO TRAIN KEN OR

1109
00:49:02,720 --> 00:49:06,557
DORIS ON THIS BECAUSE THIS IS

1110
00:49:06,557 --> 00:49:07,658
JUST WHO THEY WERE AS PEOPLE.

1111
00:49:07,658 --> 00:49:09,827
AS ETHICAL, MORAL PEOPLE WHO

1112
00:49:09,827 --> 00:49:14,031
WERE COMMITTED TO WELCOMING

1113
00:49:14,031 --> 00:49:15,566
EVERYONE AND TREATING THEM

1114
00:49:15,566 --> 00:49:17,868
EQUALLY, AND MAKING SURE THAT

1115
00:49:17,868 --> 00:49:19,403
THEIR OPPORTUNITIES AND DREAMS

1116
00:49:19,403 --> 00:49:22,139
WERE ABLE TO BE FULFILLED.

1117
00:49:22,139 --> 00:49:25,643
AND THAT'S WHY I'M HERE TODAY,

1118
00:49:25,643 --> 00:49:27,845
AS A TENURED INVESTIGATOR AT

1119
00:49:27,845 --> 00:49:31,348
NIH, ONE OF THE FEW AFRICAN

1120
00:49:31,348 --> 00:49:33,818
AMERICAN WOMEN TENURED AT NIH,

1121
00:49:33,818 --> 00:49:35,519
AND THAT'S BECAUSE OF THE

1122
00:49:35,519 --> 00:49:37,488
INVESTMENT OF VIL BOHR BUT ALSO

1123
00:49:37,488 --> 00:49:38,923
KEN KRAEMER, AND I WASN'T EVEN

1124
00:49:38,923 --> 00:49:41,659
IN HIS LAB, I WASN'T EVEN IN HIS

1125
00:49:41,659 --> 00:49:43,327
INSTITUTE, AS HE REACHED ACROSS

1126
00:49:43,327 --> 00:49:45,729
TO JUST MAKE SURE THAT I HAD THE

1127
00:49:45,729 --> 00:49:47,498
SUPPORT AND GUIDANCE THAT HE

1128
00:49:47,498 --> 00:49:49,900
FELT THAT I NEEDED.

1129
00:49:49,900 --> 00:49:52,536
BECAUSE HE SAW POTENTIAL, AND HE

1130
00:49:52,536 --> 00:49:55,806
DIDN'T CARE WHAT PACKAGE THE

1131
00:49:55,806 --> 00:49:57,141
POTENTIAL CAME IN, HE INVESTED

1132
00:49:57,141 --> 00:49:57,708
IN.

1133
00:49:57,708 --> 00:49:59,543
AND FOR THAT, I AM ETERNALLY

1134
00:49:59,543 --> 00:50:00,110
GRATEFUL.

1135
00:50:00,110 --> 00:50:03,380
THANK YOU, KEN, AND THANK YOU,

1136
00:50:03,380 --> 00:50:05,950
DORIS, NOT ONLY FOR REACHING OUT

1137
00:50:05,950 --> 00:50:07,485
TO ME AT SOME OF THOSE MEETINGS

1138
00:50:07,485 --> 00:50:08,886
WHERE I REALLY DIDN'T HAVE

1139
00:50:08,886 --> 00:50:11,188
ANYBODY THAT I COULD KIND OF

1140
00:50:11,188 --> 00:50:15,025
TALK TO, AND YOU RECOGNIZING

1141
00:50:15,025 --> 00:50:16,894
THAT AWKWARDNESS AND DISCOMFORT

1142
00:50:16,894 --> 00:50:18,429
AND COMING TO MY RESCUE SO MANY

1143
00:50:18,429 --> 00:50:20,531
TIMES.

1144
00:50:20,531 --> 00:50:23,901
BUT ALSO SHOWING ME HOW TO BE A

1145
00:50:23,901 --> 00:50:26,203
PARTNER AND A SPOUSE TO A

1146
00:50:26,203 --> 00:50:27,638
SCIENTIST, BECAUSE I MARRIED

1147
00:50:27,638 --> 00:50:30,140
SOMEBODY HERE AT NIH, AND I

1148
00:50:30,140 --> 00:50:32,343
MODELED THE WAY I MANAGED MY

1149
00:50:32,343 --> 00:50:33,444
RELATIONSHIP WITH MY HUSBAND THE

1150
00:50:33,444 --> 00:50:34,879
WAY YOU MANAGE YOUR RELATIONSHIP

1151
00:50:34,879 --> 00:50:38,482
WITH KEN BECAUSE I SAW WHAT WAS

1152
00:50:38,482 --> 00:50:40,784
NECESSARY TO PROMOTE HIS SUCCESS

1153
00:50:40,784 --> 00:50:42,219
WHILE I WAS WORKING ON

1154
00:50:42,219 --> 00:50:44,188
DEVELOPING MY OWN CAREER AND

1155
00:50:44,188 --> 00:50:46,156
RAISING MY OWN FAMILY.

1156
00:50:46,156 --> 00:50:48,058
SO THANK YOU, DORIS, FOR

1157
00:50:48,058 --> 00:50:50,427
REACHING OUT IN YOUR SPECIAL WAY

1158
00:50:50,427 --> 00:50:52,730
TO REALLY MAKE MY LIFE EASIER BY

1159
00:50:52,730 --> 00:50:54,798
GIVING ME A PATTERN TO FOLLOW.

1160
00:50:54,798 --> 00:50:56,000
SO THANK YOU BOTH, AND I WISH

1161
00:50:56,000 --> 00:50:57,835
YOU ALL THE BEST IN YOUR

1162
00:50:57,835 --> 00:50:58,435
RETIREMENT.

1163
00:50:58,435 --> 00:51:08,612
[APPLAUSE]

1164
00:51:17,821 --> 00:51:21,091
>> THANK YOU, MICHELE.

1165
00:51:21,091 --> 00:51:22,293
WE'RE HEARING AGAIN ABOUT HOW

1166
00:51:22,293 --> 00:51:27,331
CARING AND HOW GENUINE KEN IS.

1167
00:51:27,331 --> 00:51:29,500
WHEN I STARTED HERE THE FIRST

1168
00:51:29,500 --> 00:51:31,835
FEW WEEKS, I WAS WALKING FROM

1169
00:51:31,835 --> 00:51:34,438
THE PARKING LOT TO THE BUILDING

1170
00:51:34,438 --> 00:51:35,873
AND KEN WAS THERE WITH A BAG IN

1171
00:51:35,873 --> 00:51:36,340
HIS HAND.

1172
00:51:36,340 --> 00:51:42,346
SO I SAID KEN, HO ARE YOU, YES,T

1173
00:51:42,346 --> 00:51:43,480
QUESTION HE ASKED WAS, DO YOU

1174
00:51:43,480 --> 00:51:44,348
LIKE FISH?

1175
00:51:44,348 --> 00:51:45,115
AND I SAID YEAH.

1176
00:51:45,115 --> 00:51:46,650
AND HE GOES, WELL, YOU SHOULD

1177
00:51:46,650 --> 00:51:49,920
NOT BUY FISH FROM SUPERMARKETS.

1178
00:51:49,920 --> 00:51:51,689
THERE IS A FISHERMAN WHO COMES

1179
00:51:51,689 --> 00:51:54,858
ONCE IN A WHILE TO THE PARKING

1180
00:51:54,858 --> 00:51:59,697
LOT ACROSS OUR BUILDING, THAT'S

1181
00:51:59,697 --> 00:52:01,665
WHERE YOU SHOULD BUY IT FROM,

1182
00:52:01,665 --> 00:52:02,766
AND I'LL TELL YOU HOW TO DO

1183
00:52:02,766 --> 00:52:03,400
THAT.

1184
00:52:03,400 --> 00:52:04,969
AND I JUST LISTENED TO HIM AND

1185
00:52:04,969 --> 00:52:07,271
SAID THIS IS A GENUINE GUY WHO

1186
00:52:07,271 --> 00:52:08,472
REALLY CARES FOR YOU.

1187
00:52:08,472 --> 00:52:11,542
HE NOT ONLY SHARED -- YOU CAN

1188
00:52:11,542 --> 00:52:12,643
HEAR FROM EVERYBODY WHO IS HERE,

1189
00:52:12,643 --> 00:52:15,379
I THINK HE REALLY TAKES YOU

1190
00:52:15,379 --> 00:52:16,814
SERIOUSLY, SO GREAT JOB.

1191
00:52:16,814 --> 00:52:17,247
OKAY.

1192
00:52:17,247 --> 00:52:19,984
NOW WE'RE GOING TO HAVE A SERIES

1193
00:52:19,984 --> 00:52:22,853
OF WEBEX PRESENTATIONS.

1194
00:52:22,853 --> 00:52:25,923
THE FIRST ONE IS FROM YVES

1195
00:52:25,923 --> 00:52:26,156
POMMIER.

1196
00:52:26,156 --> 00:52:26,690
>> YES, HI.

1197
00:52:26,690 --> 00:52:33,030
CAN YOU HEAR ME?

1198
00:52:33,030 --> 00:52:34,198
CAN YOU HEAR ME?

1199
00:52:34,198 --> 00:52:34,765
>> YES.

1200
00:52:34,765 --> 00:52:36,634
>> HELLO.

1201
00:52:36,634 --> 00:52:38,202
KEN, I APOLOGIZE FOR NOT BEING

1202
00:52:38,202 --> 00:52:41,472
WITH YOU BECAUSE I CANNOT NOW,

1203
00:52:41,472 --> 00:52:43,674
BUT I'M REALLY WITH YOU.

1204
00:52:43,674 --> 00:52:46,310
KEN HAS BEEN A BIG PART FOR ME,

1205
00:52:46,310 --> 00:52:49,713
YOU KNOW, I CAME TO THE NIH AS A

1206
00:52:49,713 --> 00:52:52,349
POSTDOC, AND I WAS WITH AN

1207
00:52:52,349 --> 00:52:56,520
OUTSTANDING MENTOR, DR. CURT

1208
00:52:56,520 --> 00:53:00,691
COHEN, WHO HAD ACTUALLY HIRED

1209
00:53:00,691 --> 00:53:01,458
VIL BOHR AS WELL.

1210
00:53:01,458 --> 00:53:04,862
WE WERE WORKING ON DNA DAMAGE,

1211
00:53:04,862 --> 00:53:06,930
I'LL GIVE YOU THREE LITTLE

1212
00:53:06,930 --> 00:53:08,799
TIDBITS THAT CHANGED MY LIFE.

1213
00:53:08,799 --> 00:53:11,902
WORKING ON DNA DAMAGE, AND KEN

1214
00:53:11,902 --> 00:53:13,871
WAS REALLY INTERESTED IN BLOOM

1215
00:53:13,871 --> 00:53:15,372
SYNDROME, THAT WAS IN 1990.

1216
00:53:15,372 --> 00:53:17,808
IN 1990, WE DIDN'T KNOW VERY

1217
00:53:17,808 --> 00:53:20,110
MUCH ABOUT THE CAUSE OF BLUE

1218
00:53:20,110 --> 00:53:24,381
SYNDROME, AND THERE WAS A

1219
00:53:24,381 --> 00:53:25,716
SUSPICION TOPO ISOMERS WERE

1220
00:53:25,716 --> 00:53:25,983
INVOLVED.

1221
00:53:25,983 --> 00:53:29,586
KEN WAS ASKING ME TO MEASURE THE

1222
00:53:29,586 --> 00:53:32,956
DNA DAMAGE WITH THE --

1223
00:53:32,956 --> 00:53:38,028
ENRICHMENT FACTOR AND WE

1224
00:53:38,028 --> 00:53:38,829
HYPOTHESIZED IT WAS -- 2.

1225
00:53:38,829 --> 00:53:40,431
I DID ALL THE EXPERIMENTS, I WAS

1226
00:53:40,431 --> 00:53:42,599
GOING BACK AND FORTH AND

1227
00:53:42,599 --> 00:53:46,770
EVERYTHING ACTUALLY WAS

1228
00:53:46,770 --> 00:53:47,137
AGAINST -- 2.

1229
00:53:47,137 --> 00:53:49,873
WE ENDED UP PUBLISHING THIS WORK

1230
00:53:49,873 --> 00:53:53,277
ARGUING THAT IT WAS NOT

1231
00:53:53,277 --> 00:53:55,979
ASSOCIATED WITH BLUE CENTRAL,

1232
00:53:55,979 --> 00:53:58,449
AND THAT FOR ME WAS AN

1233
00:53:58,449 --> 00:54:00,084
ENLIGHTENING EXPERIENCE BECAUSE

1234
00:54:00,084 --> 00:54:01,185
YOU CAN'T FORCE SCIENCE, YOU

1235
00:54:01,185 --> 00:54:04,121
HAVE TO FOLLOW WHAT THE DATA ARE

1236
00:54:04,121 --> 00:54:06,090
SHOWING YOU, AND AS WE STARTED

1237
00:54:06,090 --> 00:54:07,958
WRITING THAT PAPER, I ALSO

1238
00:54:07,958 --> 00:54:11,929
REALIZED HOW CAREFUL KEN WAS IN

1239
00:54:11,929 --> 00:54:13,197
EVERY WORD THAT HE WOULD PUT IN

1240
00:54:13,197 --> 00:54:13,697
THE PAPER.

1241
00:54:13,697 --> 00:54:15,432
YOU KNOW, YOU COULD HEAR IT.

1242
00:54:15,432 --> 00:54:19,636
I'M NOT A ENGLISH-SPEAKING-BORN

1243
00:54:19,636 --> 00:54:21,705
PERSON, BUT KEN WAS WONDERFUL,

1244
00:54:21,705 --> 00:54:23,340
YOU KNOW.

1245
00:54:23,340 --> 00:54:24,475
THE DIFFERENCE BETWEEN

1246
00:54:24,475 --> 00:54:27,077
DEMONSTRATES, INDICATES, SHOWS,

1247
00:54:27,077 --> 00:54:28,946
WAS VERY CLEAR AT THAT TIME, AND

1248
00:54:28,946 --> 00:54:30,748
KEN PUT HIS FINGER RIGHT ON

1249
00:54:30,748 --> 00:54:32,483
EVERYTHING, EVERY SLIDE, EVERY

1250
00:54:32,483 --> 00:54:34,017
FIGURE, EVERYTHING WONDERFUL.

1251
00:54:34,017 --> 00:54:35,753
CURT WAS THE SAME BUT KEN WAS

1252
00:54:35,753 --> 00:54:37,521
REALLY OUTSTANDING.

1253
00:54:37,521 --> 00:54:40,824
THE SECOND STEP ON MY -- I KEPT

1254
00:54:40,824 --> 00:54:43,327
SEEING KEN ALL THE TIME, I LOVED

1255
00:54:43,327 --> 00:54:45,562
GOING TO HIS OFFICE.

1256
00:54:45,562 --> 00:54:47,865
THE FIRST TIME I CAME TO KEN'S

1257
00:54:47,865 --> 00:54:52,236
OFFICE, IT WAS LIKE WONDERFUL I

1258
00:54:52,236 --> 00:54:54,104
ENTER, I SEE THIS PERSON SITTING

1259
00:54:54,104 --> 00:54:56,540
ON A CHAIR IN THE MIDDLE OF PILE

1260
00:54:56,540 --> 00:54:59,810
OF PAPERS, HUGE PILES, BOOKS,

1261
00:54:59,810 --> 00:55:01,245
PAPERS, AND THEN I ASK A

1262
00:55:01,245 --> 00:55:03,046
QUESTION TO KEN, I SAY, OH, WAIT

1263
00:55:03,046 --> 00:55:04,782
A MINUTE, AND HE WOULD GO UNDER

1264
00:55:04,782 --> 00:55:06,650
THE PILE, PULL OUT IN A LITTLE

1265
00:55:06,650 --> 00:55:08,619
CORNER A PIECE OF PAPER AND HE'D

1266
00:55:08,619 --> 00:55:11,121
SHOW ME A GRAPH.

1267
00:55:11,121 --> 00:55:12,489
HE WAS SO SMART, I THOUGHT THAT

1268
00:55:12,489 --> 00:55:14,892
HE COULD PUT HIS DESK IN ORDER

1269
00:55:14,892 --> 00:55:15,893
BECAUSE HE KNEW WHERE EVERYTHING

1270
00:55:15,893 --> 00:55:16,260
WAS.

1271
00:55:16,260 --> 00:55:20,030
I COULD NEVER DO THIS.

1272
00:55:20,030 --> 00:55:24,768
SO THE SECOND TIME THAT I GOT TO

1273
00:55:24,768 --> 00:55:26,069
AN EXPERIENCE WITH KEN WAS FOR

1274
00:55:26,069 --> 00:55:28,038
ANOTHER STUDY WHERE WE WERE

1275
00:55:28,038 --> 00:55:30,908
STUDYING DNA DAMAGE -- WHICH IS

1276
00:55:30,908 --> 00:55:38,482
NOT APPROVED IN THE CLINIC, 743,

1277
00:55:38,482 --> 00:55:39,483
TRABECTADINE.

1278
00:55:39,483 --> 00:55:41,785
WHAT WE HAD IDENTIFIED WAS

1279
00:55:41,785 --> 00:55:43,120
THE -- WE DIDN'T KNOW THE TARGET

1280
00:55:43,120 --> 00:55:44,721
AND IDENTIFYING RESISTANT CELL

1281
00:55:44,721 --> 00:55:46,857
LINE THAT INACTIVATION OF XP

1282
00:55:46,857 --> 00:55:50,894
GWAS MAKING THE CELLS RESISTANT.

1283
00:55:50,894 --> 00:55:52,896
AND I WENT TO KEN AND I SAID,

1284
00:55:52,896 --> 00:55:55,732
KEN, I NEED AN ISOGENIC CELL

1285
00:55:55,732 --> 00:55:55,933
LINE.

1286
00:55:55,933 --> 00:55:57,835
KEN HAD THIS WONDERFUL

1287
00:55:57,835 --> 00:56:00,237
COLLECTION OF ISOGENIC CELL

1288
00:56:00,237 --> 00:56:02,105
LINES, WE DID ALL THE CONTROLS

1289
00:56:02,105 --> 00:56:06,143
LIKE KEN VERY THRUR THOROUGHLY ,

1290
00:56:06,143 --> 00:56:10,347
AND WE ENDED UP DISCOVERING

1291
00:56:10,347 --> 00:56:11,882
THAT -- THE DRUG IS

1292
00:56:11,882 --> 00:56:14,051
FDA-APPROVED, IT'S USED IN

1293
00:56:14,051 --> 00:56:15,953
CANCER, AND THIS DISCOVERY WAS

1294
00:56:15,953 --> 00:56:17,487
VERY IMPORTANT FOR THAT.

1295
00:56:17,487 --> 00:56:19,656
BUT IT WAS ALSO EXTREMELY

1296
00:56:19,656 --> 00:56:20,757
IMPORTANT BECAUSE THERE WAS THE

1297
00:56:20,757 --> 00:56:26,797
TIME WHERE I WAS BECOMING -- I

1298
00:56:26,797 --> 00:56:28,999
WAS POSTULATING TO BECOME A

1299
00:56:28,999 --> 00:56:31,835
P.I., AND THANKS TO KEN, I THINK

1300
00:56:31,835 --> 00:56:34,605
KEN THIS PAPER WE PUBLISHED IN

1301
00:56:34,605 --> 00:56:38,108
NATURE MEDICINE PROBABLY WAS A

1302
00:56:38,108 --> 00:56:40,410
KEY -- IT WEIGHED A LOT WHEN I

1303
00:56:40,410 --> 00:56:43,380
WENT THROUGH THE REVIEW AND I

1304
00:56:43,380 --> 00:56:45,249
THANK YOU SO MUCH FOR EVERYTHING

1305
00:56:45,249 --> 00:56:47,117
YOU DID AND ALL YOUR CAREFUL

1306
00:56:47,117 --> 00:56:50,153
THINKING.

1307
00:56:50,153 --> 00:56:54,458
THE LAST LITTLE STORY, A LITTLE

1308
00:56:54,458 --> 00:56:55,659
LATER, ABOUT PLATINUM.

1309
00:56:55,659 --> 00:56:58,195
AS YOU KNOW, I'M WORKING WITH

1310
00:56:58,195 --> 00:56:59,429
ANTICANCER DRUG, I REALLY LOVE

1311
00:56:59,429 --> 00:57:02,032
HOW TO FIND HOW THEY WORK.

1312
00:57:02,032 --> 00:57:04,134
AND NOW IF YOU TALK PLATINUM,

1313
00:57:04,134 --> 00:57:10,841
YOU WOULD SAY BRCA 1, --

1314
00:57:10,841 --> 00:57:11,375
DEFICIENCY.

1315
00:57:11,375 --> 00:57:12,910
BUT AT THIS TIME, AND IT STILL

1316
00:57:12,910 --> 00:57:17,047
TRUE, PLATINUM IS ALSO

1317
00:57:17,047 --> 00:57:20,817
INTERFERING WITH DNA AND -- NEED

1318
00:57:20,817 --> 00:57:24,421
TO BE REPAIRED BY -- REPAIR.

1319
00:57:24,421 --> 00:57:29,793
SO THE QUESTION WAS, IS IT

1320
00:57:29,793 --> 00:57:31,561
GLOBAL TRANSCRIPTION -- REPAIR

1321
00:57:31,561 --> 00:57:33,196
OR TRANSCRIPTION -- KEN HAD ALL

1322
00:57:33,196 --> 00:57:35,399
THE TOOLS TO ACTUALLY CLEARLY

1323
00:57:35,399 --> 00:57:39,136
HELP US DEMONSTRATE THAT

1324
00:57:39,136 --> 00:57:40,337
TRANSCRIPTION COUPLE -- REPAIR

1325
00:57:40,337 --> 00:57:45,709
WAS KEY, NOT GLOBAL -- SO I

1326
00:57:45,709 --> 00:57:50,013
REALLY THANK YOU, KEN, FOR ALL

1327
00:57:50,013 --> 00:57:52,282
YOUR SUPPORT, ALL THE TIME WE

1328
00:57:52,282 --> 00:57:53,383
SPENT TOGETHER AND I WISH YOU

1329
00:57:53,383 --> 00:57:56,720
THE BEST RETIREMENT, AND YOU

1330
00:57:56,720 --> 00:57:59,723
REALLY DESERVE IT, I ENJOY IT

1331
00:57:59,723 --> 00:58:01,291
VERY MUCH, AND I HOPE TO SEE YOU

1332
00:58:01,291 --> 00:58:01,858
AT THE NIH.

1333
00:58:01,858 --> 00:58:02,726
I'M SURE WE COME BACK.

1334
00:58:02,726 --> 00:58:03,894
THANK YOU.

1335
00:58:03,894 --> 00:58:11,768
[APPLAUSE]

1336
00:58:11,768 --> 00:58:12,936
>> THANK YOU, YVES.

1337
00:58:12,936 --> 00:58:18,108
I WOULD LIKE TO NOW INVITE

1338
00:58:18,108 --> 00:58:21,311
MICHELE MILOTA TO SAY A FEW

1339
00:58:21,311 --> 00:58:31,421
WORDS.

1340
00:58:38,028 --> 00:58:39,563
>> CAN YOU HEAR ME?

1341
00:58:39,563 --> 00:58:39,763
HELLO?

1342
00:58:39,763 --> 00:58:40,330
>> WE CAN HEAR YOU.

1343
00:58:40,330 --> 00:58:42,899
>> OKAY, PERFECT.

1344
00:58:42,899 --> 00:58:45,635
AS THE DIRECTOR OF THE XP FAMILY

1345
00:58:45,635 --> 00:58:52,909
SUPPORT GROUP P IT W, IT'S WITHS

1346
00:58:52,909 --> 00:58:56,179
WE HEAR YOU'RE GOING TO RETIRE,

1347
00:58:56,179 --> 00:58:58,115
REMARKABLE MAN WHO'S DEDICATED

1348
00:58:58,115 --> 00:58:59,316
HIS CAREER TO TREATING AND

1349
00:58:59,316 --> 00:59:00,384
ENHANCING THE LIVES OF THOSE

1350
00:59:00,384 --> 00:59:01,251
AFFECTED WITH XP.

1351
00:59:01,251 --> 00:59:03,720
AS YOU JOURNEY AWAY FROM US AND

1352
00:59:03,720 --> 00:59:06,456
WE'RE GOING TO MISS YOU DEARLY,

1353
00:59:06,456 --> 00:59:07,657
YOU'RE NOTHING SHORT OF

1354
00:59:07,657 --> 00:59:09,159
EXTRAORDINARY, AND THE WORLD

1355
00:59:09,159 --> 00:59:10,827
WHERE XP PRESENTS UNIQUE

1356
00:59:10,827 --> 00:59:12,262
CHALLENGES AND UNWAVERING

1357
00:59:12,262 --> 00:59:14,231
COMMITMENT AND EXPERTISE, YOU'VE

1358
00:59:14,231 --> 00:59:15,365
ILLUMINATED THE PATH FOR

1359
00:59:15,365 --> 00:59:18,969
COUNTLESS FAMILIES.

1360
00:59:18,969 --> 00:59:20,404
YOU'VE NOT ONLY PROVIDED MEDICAL

1361
00:59:20,404 --> 00:59:21,505
CARE, ANSWERED NUMEROUS

1362
00:59:21,505 --> 00:59:23,073
QUESTIONS AND HAVE RESEARCHED XP

1363
00:59:23,073 --> 00:59:24,374
FOR YOUR CAREER, BUT YOU ALSO

1364
00:59:24,374 --> 00:59:26,810
HAVE OFFERED US HOPE.

1365
00:59:26,810 --> 00:59:29,312
AND THE STRENGTH TORE FACE THE

1366
00:59:29,312 --> 00:59:32,416
COMPLEXITIES OF THIS CONDITION.

1367
00:59:32,416 --> 00:59:34,051
I REMEMBER WHEN MY DAUGHTER WAS

1368
00:59:34,051 --> 00:59:37,154
DIAGNOSED TW 20 YEARS AGO AND YU

1369
00:59:37,154 --> 00:59:37,988
AND DEBBY AND JOHN WERE THE

1370
00:59:37,988 --> 00:59:39,356
FIRST FACES THAT WE MET THAT

1371
00:59:39,356 --> 00:59:42,826
HELPED US TO OVERCOME THE

1372
00:59:42,826 --> 00:59:44,194
CHALLENGE, SHOWED US THAT WE HAD

1373
00:59:44,194 --> 00:59:45,729
HOPE, SHOWED US THAT WE COULD

1374
00:59:45,729 --> 00:59:47,364
LIVE WITH THIS CONDITION, AND

1375
00:59:47,364 --> 00:59:52,536
YOU GAVE US THE TOOLS NEEDED TO

1376
00:59:52,536 --> 00:59:54,071
LIVE MY DAUGHTER'S LIFE TO HER

1377
00:59:54,071 --> 00:59:54,304
FULLEST.

1378
00:59:54,304 --> 00:59:56,139
I WANT TO SAY THAT SHE'S NOW

1379
00:59:56,139 --> 00:59:58,141
DEDICATING HER CAREER AS A MICRO

1380
00:59:58,141 --> 00:59:59,242
BIOLOGIST AND WANTS TO DO

1381
00:59:59,242 --> 01:00:00,277
RESEARCH.

1382
01:00:00,277 --> 01:00:02,746
SO NOT ONLY DID YOU INSPIRE ME

1383
01:00:02,746 --> 01:00:04,848
TO START THE XP FAMILY SUPPORT

1384
01:00:04,848 --> 01:00:06,516
GROUP BUT YOU'VE ALSO LIT A FIRE

1385
01:00:06,516 --> 01:00:07,984
IN MY DAUGHTER'S LIFE WHERE SHE

1386
01:00:07,984 --> 01:00:09,719
WANTS TO MAKE A DIFFERENCE IN

1387
01:00:09,719 --> 01:00:13,123
PEOPLE'S LIVES WITH XP AS WELL.

1388
01:00:13,123 --> 01:00:15,525
YOUR RESEARCH AND ADVOCACY HAVE

1389
01:00:15,525 --> 01:00:16,993
PLAYED A PIVOTAL ROLE IN

1390
01:00:16,993 --> 01:00:20,197
BRINGING XP INTO THE BROADER

1391
01:00:20,197 --> 01:00:22,032
MEDICAL AND PUBLIC AWARENESS.

1392
01:00:22,032 --> 01:00:23,166
WITHOUT YOU, KEN, WE WOULDN'T

1393
01:00:23,166 --> 01:00:25,902
HAVE BEEN ABLE TO GO OUT THERE

1394
01:00:25,902 --> 01:00:29,072
AND TO EDUCATE DOCTORS AND

1395
01:00:29,072 --> 01:00:29,973
DERMATOLOGISTS AND RESEARCHERS

1396
01:00:29,973 --> 01:00:32,142
ON THIS CONDITION.

1397
01:00:32,142 --> 01:00:33,243
YOU'VE CHAMPIONED THE CAUSE

1398
01:00:33,243 --> 01:00:35,712
SECURING FUNDING FOR RESEARCH,

1399
01:00:35,712 --> 01:00:38,448
IMPROVING THE QUALITY OF CARE,

1400
01:00:38,448 --> 01:00:42,486
MAKING SIGNIFICANT STRIDES IN

1401
01:00:42,486 --> 01:00:43,120
TREATMENT OPTIONS.

1402
01:00:43,120 --> 01:00:44,254
YOUR EFFORTS HAVE NOT ONLY

1403
01:00:44,254 --> 01:00:45,856
BENEFITED OUR LOCAL XP FAMILIES

1404
01:00:45,856 --> 01:00:48,325
AND COMMUNITY, BUT RESONATED

1405
01:00:48,325 --> 01:00:50,193
ACROSS THE GLOBE, IMPROVING

1406
01:00:50,193 --> 01:00:51,328
LIVES OF THOSE AFFECTED

1407
01:00:51,328 --> 01:00:52,729
WORLDWIDE.

1408
01:00:52,729 --> 01:00:54,698
ALL OF US, ALL OF THE SUPPORT

1409
01:00:54,698 --> 01:00:56,333
GROUPS AROUND THE WORLD LOOK TO

1410
01:00:56,333 --> 01:00:58,468
YOU, KEN, FOR YOUR RESEARCH,

1411
01:00:58,468 --> 01:01:00,570
YOUR GUIDANCE, YOUR

1412
01:01:00,570 --> 01:01:02,973
COLLABORATION WITH OTHER

1413
01:01:02,973 --> 01:01:03,540
COUNTRIES.

1414
01:01:03,540 --> 01:01:05,275
I REMEMBER COMING TO THE XP TASK

1415
01:01:05,275 --> 01:01:06,810
FORCE MEETINGS AND MEETING

1416
01:01:06,810 --> 01:01:08,545
DOCTORS FROM AROUND THE WORLD,

1417
01:01:08,545 --> 01:01:10,213
SITTING AT ROUNDTABLES JUST

1418
01:01:10,213 --> 01:01:12,516
COLLABORATING AND TALKING WITH

1419
01:01:12,516 --> 01:01:14,885
DOCTORS THAT GAVE US XP FAMILIES

1420
01:01:14,885 --> 01:01:16,019
HOPE THAT THERE IS RESEARCH OUT

1421
01:01:16,019 --> 01:01:18,054
THERE AND THAT YOU ALL DO WORK

1422
01:01:18,054 --> 01:01:18,488
TOGETHER.

1423
01:01:18,488 --> 01:01:19,689
AND WITHOUT YOUR GUIDANCE, WE

1424
01:01:19,689 --> 01:01:22,526
WOULDN'T HAVE THAT.

1425
01:01:22,526 --> 01:01:24,661
ON BEHALF OF THE XP FAMILY

1426
01:01:24,661 --> 01:01:26,096
SUPPORT IMREUP AND THE COUNTLESS

1427
01:01:26,096 --> 01:01:27,597
FAMILIES AND PATIENTS WHOSE

1428
01:01:27,597 --> 01:01:28,431
LIVES YOU'VE TOUCHED, WE SAY

1429
01:01:28,431 --> 01:01:28,798
THANK YOU.

1430
01:01:28,798 --> 01:01:30,167
THANK YOU FOR YOUR YEARS OF

1431
01:01:30,167 --> 01:01:32,469
SERVICE, FOR YOUR HEART, YOUR

1432
01:01:32,469 --> 01:01:33,336
DEDICATION IN MAKING A

1433
01:01:33,336 --> 01:01:35,338
DIFFERENCE IN THE WORLD OF XP.

1434
01:01:35,338 --> 01:01:37,674
I KNOW DORIS HAS BEEN WAITING TO

1435
01:01:37,674 --> 01:01:39,309
TRAVEL, SPEND TIME WITH THOSE

1436
01:01:39,309 --> 01:01:43,680
GRANDKIDS AT EVERY MEETING I'D

1437
01:01:43,680 --> 01:01:45,015
HEAR SHE'D TALK ABOUT ALL THE

1438
01:01:45,015 --> 01:01:46,016
GRANDKIDS AND WHAT YOU GUYS WERE

1439
01:01:46,016 --> 01:01:47,317
GOING TO DO WHEN YOU RETIRED AND

1440
01:01:47,317 --> 01:01:49,452
SHE'S BEEN TALKING TO ME ABOUT

1441
01:01:49,452 --> 01:01:50,687
THAT FOR THE LAST 18 YEARS SO I

1442
01:01:50,687 --> 01:01:53,190
KNOW SHE'S READY TO START

1443
01:01:53,190 --> 01:01:54,824
ENJOYING LIFE WITH YOU.

1444
01:01:54,824 --> 01:01:57,160
IT'S A WELL-DESERVED RETIREMENT.

1445
01:01:57,160 --> 01:01:58,695
KNOW THAT YOU'VE CHANGED THE

1446
01:01:58,695 --> 01:01:59,896
WORLD, YOU'VE MADE IT A BETTER

1447
01:01:59,896 --> 01:02:02,132
PLACE FOR XP FAMILIES, KEN.

1448
01:02:02,132 --> 01:02:03,833
WE WILL THOROUGHLY MISS YOU BUT

1449
01:02:03,833 --> 01:02:05,402
I KNOW OUR PATHS WILL CROSS AND

1450
01:02:05,402 --> 01:02:07,070
CHEERS TO YOU AND YOUR FAMILY

1451
01:02:07,070 --> 01:02:09,739
AND ENJOY YOUR RETIREMENT.

1452
01:02:09,739 --> 01:02:18,582
[APPLAUSE]

1453
01:02:18,582 --> 01:02:22,185
>> THANK YOU, MICHELE.

1454
01:02:22,185 --> 01:02:24,221
WHETHER WE ARE PH.D. OR M.D., WE

1455
01:02:24,221 --> 01:02:25,322
ALL WOULD LIKE TO MAKE A

1456
01:02:25,322 --> 01:02:26,623
DIFFERENCE IN SOMEBODY'S LIFE

1457
01:02:26,623 --> 01:02:27,457
WITH A DISEASE.

1458
01:02:27,457 --> 01:02:29,626
IT IS SO IMPRESSIVE TO SEE AN

1459
01:02:29,626 --> 01:02:33,129
IMPACT YOU HAVE MADE AND TO HEAR

1460
01:02:33,129 --> 01:02:35,332
MICHELE LAY IT OUT, IT'S TRULY

1461
01:02:35,332 --> 01:02:35,899
MOVING.

1462
01:02:35,899 --> 01:02:37,334
SO CONGRATULATIONS ON HAVING AN

1463
01:02:37,334 --> 01:02:38,768
IMPACT ON SO MANY FAMILIES

1464
01:02:38,768 --> 01:02:39,336
AROUND THE WORLD.

1465
01:02:39,336 --> 01:02:45,208
[APPLAUSE]

1466
01:02:45,208 --> 01:02:48,545
UP NEXT, I WOULD LIKE TO INVITE

1467
01:02:48,545 --> 01:02:50,380
ROBERT SARKANY, SPEAKING FROM

1468
01:02:50,380 --> 01:02:52,148
ACROSS THE POND.

1469
01:02:52,148 --> 01:02:56,820
MUST BE LIKE 9:00 P.M. FOR HIM.

1470
01:02:56,820 --> 01:02:57,921
SO GO AHEAD, ROBERT.

1471
01:02:57,921 --> 01:02:59,189
>> THANK YOU VERY MUCH FOR

1472
01:02:59,189 --> 01:02:59,756
INVITING ME.

1473
01:02:59,756 --> 01:03:01,791
I'M REALLY PLEASED TO ALMOST,

1474
01:03:01,791 --> 01:03:06,563
LOW PRESSURE BALMOST BE WITH YO.

1475
01:03:06,563 --> 01:03:09,132
I'M BOB SARKANY, DERMATOLOGIST,

1476
01:03:09,132 --> 01:03:11,334
IN 2006 I TOOK OVER OF THE

1477
01:03:11,334 --> 01:03:15,805
SENSITIVITY DISORDERS UNIT AT

1478
01:03:15,805 --> 01:03:17,007
THE -- DERMATOLOGY IN LONDON.

1479
01:03:17,007 --> 01:03:20,677
AND IT WAS VERY APPARENT TO

1480
01:03:20,677 --> 01:03:23,413
ME -- WE HAD A SMALL GROUP OF XP

1481
01:03:23,413 --> 01:03:24,714
PATIENTS, AND THEY WERE NOT --

1482
01:03:24,714 --> 01:03:26,416
WE WERE NOT PROVIDING EXPERT

1483
01:03:26,416 --> 01:03:28,718
ENOUGH CARE AND THEY CLEARLY

1484
01:03:28,718 --> 01:03:31,121
NEEDED EXPERT DISCIPLINARY CARE,

1485
01:03:31,121 --> 01:03:33,490
AND I WANTED TO SET OUT SOME

1486
01:03:33,490 --> 01:03:35,091
SORT OF DEDICATED XP SERVICE.

1487
01:03:35,091 --> 01:03:36,860
I HAD NO IDEA HOW TO DO IT, I

1488
01:03:36,860 --> 01:03:38,595
DIDN'T KNOW MUCH ABOUT XP, AND

1489
01:03:38,595 --> 01:03:41,164
EVERYONE I ASKED IN ENGLAND, I

1490
01:03:41,164 --> 01:03:43,566
STARTED WITH ALAN LEHMAN AND

1491
01:03:43,566 --> 01:03:45,602
SAID, WHO DO I ASK?

1492
01:03:45,602 --> 01:03:49,005
I'VE READ A COUPLE OF PAPERS, OF

1493
01:03:49,005 --> 01:03:50,640
COURSE KEN KRAEMER IS THE ONE.

1494
01:03:50,640 --> 01:03:53,109
HE'S THE ONE WHO KNOWS.

1495
01:03:53,109 --> 01:03:55,612
I HAD MY OPPORTUNITY PRETTY

1496
01:03:55,612 --> 01:04:01,418
QUICKLY.

1497
01:04:01,418 --> 01:04:03,586
I'VE GOT SOME SLIDES OF

1498
01:04:03,586 --> 01:04:05,588
MEETINGS, A COUPLE OF MEETINGS

1499
01:04:05,588 --> 01:04:06,589
THAT KEN RAN.

1500
01:04:06,589 --> 01:04:09,559
AND THIS -- IS IT SHARING?

1501
01:04:09,559 --> 01:04:12,929
IS IT SHARING?

1502
01:04:12,929 --> 01:04:14,331
CAN I JUST -- I'LL TRY THAT

1503
01:04:14,331 --> 01:04:17,033
AGAIN.

1504
01:04:17,033 --> 01:04:26,343
IS THAT SHARING?

1505
01:04:26,343 --> 01:04:30,480
YOU GOT SOMETHING NOW?

1506
01:04:30,480 --> 01:04:31,481
DURING 2006, THIS IS ACTUALLY

1507
01:04:31,481 --> 01:04:33,383
THE WRONG SLIDE WHICH DOESN'T

1508
01:04:33,383 --> 01:04:35,452
HELP REALLY MY CAUSE, BUT IN

1509
01:04:35,452 --> 01:04:38,521
2006, I WENT ALONG TO THE

1510
01:04:38,521 --> 01:04:39,189
ININTERNATIONAL SYMPOSIUM WHICH

1511
01:04:39,189 --> 01:04:41,224
IS HELD EVERY FOUR YEARS IN THE

1512
01:04:41,224 --> 01:04:43,293
XP AND DNA REPAIR DISEASE

1513
01:04:43,293 --> 01:04:47,997
COMMUNITY HELD BY -- HOSTED BY

1514
01:04:47,997 --> 01:04:51,901
DORIS AND KEN WITH YOU IN

1515
01:04:51,901 --> 01:04:53,169
VIRGINIA.

1516
01:04:53,169 --> 01:04:54,170
AND IT WAS KNOCKOUT.

1517
01:04:54,170 --> 01:04:56,339
I WAS SORT OF THINKING SHOULD I

1518
01:04:56,339 --> 01:04:57,707
SET UP A SERVICE?

1519
01:04:57,707 --> 01:04:59,342
JOHN, DORIS, KEN WERE JUST SO

1520
01:04:59,342 --> 01:04:59,542
NICE.

1521
01:04:59,542 --> 01:05:02,512
IT WAS SO INTERESTING.

1522
01:05:02,512 --> 01:05:05,815
AND WHAT REALLY STRUCK ME AS

1523
01:05:05,815 --> 01:05:07,484
WELL, APART FROM THE

1524
01:05:07,484 --> 01:05:08,251
CLASSIFICATION OF THE DISEASE

1525
01:05:08,251 --> 01:05:09,719
OBVIOUSLY WAS INTERESTING WAS

1526
01:05:09,719 --> 01:05:11,521
THAT THEY SEEMED TO -- IT WAS

1527
01:05:11,521 --> 01:05:12,922
VERY STRIKING, THEY WERE

1528
01:05:12,922 --> 01:05:14,524
TREATING THE PATIENTS WHO WERE

1529
01:05:14,524 --> 01:05:15,759
AT THE CONFERENCE AS EQUAL TO

1530
01:05:15,759 --> 01:05:17,627
THE CLINICIANS AND SCIENTISTS.

1531
01:05:17,627 --> 01:05:18,962
I'D NEVER COME ACROSS THAT

1532
01:05:18,962 --> 01:05:19,229
ANYWHERE.

1533
01:05:19,229 --> 01:05:21,398
I WAS VERY STRUCK BY THAT.

1534
01:05:21,398 --> 01:05:24,000
BUT I STOOD UP A

1535
01:05:24,000 --> 01:05:24,934
MULTIDISCIPLINARY SERVICE, A

1536
01:05:24,934 --> 01:05:26,236
VERY SMALL ONE, VOLUNTEERING

1537
01:05:26,236 --> 01:05:29,639
WITH NO FUNDING, RUNNING EVERY

1538
01:05:29,639 --> 01:05:32,475
FEW MONTHS, ANOTHER CLINIC

1539
01:05:32,475 --> 01:05:35,678
RUNNING IN LONDON, AND  I APPLID

1540
01:05:35,678 --> 01:05:39,082
TO THE GOVERNMENT AND GOT

1541
01:05:39,082 --> 01:05:41,584
FUNDING FOR AN ALL BELLS AND

1542
01:05:41,584 --> 01:05:43,820
WHISTLES XP NATIONAL SERVICE FOR

1543
01:05:43,820 --> 01:05:46,022
THE UK WHICH WAS REASONABLY

1544
01:05:46,022 --> 01:05:46,322
WELL-FUNDED.

1545
01:05:46,322 --> 01:05:48,158
WHERE TO GO TO FIND OUT ABOUT

1546
01:05:48,158 --> 01:05:49,793
THAT, BECAUSE IN THE

1547
01:05:49,793 --> 01:05:51,294
INTERMEDIATE TIME, I'D BEEN

1548
01:05:51,294 --> 01:05:52,862
LEARNING ABOUT XP EVERY YEAR BY

1549
01:05:52,862 --> 01:05:54,898
GOING TO KEN'S WONDERFUL -- KEN

1550
01:05:54,898 --> 01:05:56,866
AND JOHN'S WONDERFUL SESSION

1551
01:05:56,866 --> 01:05:59,936
ABOUT XP AT THE AMERICAN ACADEMY

1552
01:05:59,936 --> 01:06:02,038
OF DERMATOLOGY.

1553
01:06:02,038 --> 01:06:03,473
ANNUAL VISIT.

1554
01:06:03,473 --> 01:06:05,875
AND WENT IN 2010, THEN, TO THE

1555
01:06:05,875 --> 01:06:07,310
NEXT INTERNATIONAL SYMPOSIUM AND

1556
01:06:07,310 --> 01:06:08,178
ALTHOUGH THIS IS AN

1557
01:06:08,178 --> 01:06:09,012
INTERNATIONAL COMMUNITY, AGAIN,

1558
01:06:09,012 --> 01:06:12,849
IT WAS HOSTED BY KEN AND JOHN

1559
01:06:12,849 --> 01:06:15,885
AND DORIS, AND AGAIN IT WAS AN

1560
01:06:15,885 --> 01:06:20,790
ABSOLUTELY WONDERFUL MEETING,

1561
01:06:20,790 --> 01:06:23,426
AND -- I PICKED THE WRONG SLIDE.

1562
01:06:23,426 --> 01:06:24,694
I'LL STOP THAT.

1563
01:06:24,694 --> 01:06:26,296
IT'S A GOOD SLIDE AND IT'S WORTH

1564
01:06:26,296 --> 01:06:27,931
SEEING AND I APOLOGIZE FOR

1565
01:06:27,931 --> 01:06:38,208
MESSING THAT UP.

1566
01:06:41,344 --> 01:06:43,913
IS THAT SHARING?

1567
01:06:43,913 --> 01:06:45,648
THAT WAS THE 2006.

1568
01:06:45,648 --> 01:06:48,017
YOU MAY RECOGNIZE THAT.

1569
01:06:48,017 --> 01:06:51,054
2006 MEETING, THAT'S THE FRONT

1570
01:06:51,054 --> 01:06:51,955
PAGE OF YOUR THING.

1571
01:06:51,955 --> 01:06:53,790
THIS IS THE ONE FROM 2010.

1572
01:06:53,790 --> 01:06:55,258
I'VE KEPT THEM ALL BECAUSE THEY

1573
01:06:55,258 --> 01:06:55,825
WERE SO WONDERFUL.

1574
01:06:55,825 --> 01:06:59,762
AND THEN THIS IS AT THE 2010

1575
01:06:59,762 --> 01:06:59,996
MEETING.

1576
01:06:59,996 --> 01:07:01,998
KEN HAD TAKEN IN HIS STRIDE A

1577
01:07:01,998 --> 01:07:03,099
REMARKABLE THING THAT HAPPENED,

1578
01:07:03,099 --> 01:07:05,935
WHICH WAS THE VENUE FOR THIS

1579
01:07:05,935 --> 01:07:08,605
MASSIVE WORLDWIDE THING, IT WAS

1580
01:07:08,605 --> 01:07:11,241
A BIG INTERNATIONAL HIGH

1581
01:07:11,241 --> 01:07:13,443
PRESTIGE IMPORTANT WORLDWIDE

1582
01:07:13,443 --> 01:07:13,877
CONFERENCE.

1583
01:07:13,877 --> 01:07:15,712
THE NIGHT BEFOREHAND, KEN, YOU

1584
01:07:15,712 --> 01:07:17,647
I'M SURE WILL REMEMBER, KEN,

1585
01:07:17,647 --> 01:07:21,284
DORIS AND JOHN, EVERYBODY, IT

1586
01:07:21,284 --> 01:07:23,119
STOOD IN EVERYBODY'S MEMORIES,

1587
01:07:23,119 --> 01:07:24,220
THEY LOST THEIR CONFERENCE

1588
01:07:24,220 --> 01:07:24,921
CENTER.

1589
01:07:24,921 --> 01:07:26,456
AND THEY HAD TO FIND A NEW

1590
01:07:26,456 --> 01:07:28,191
CONFERENCE CENTER IN ABOUT 12

1591
01:07:28,191 --> 01:07:29,893
HOURS' NOTICE, FOUND ONE, HAD A

1592
01:07:29,893 --> 01:07:30,760
WONDERFUL MEETING.

1593
01:07:30,760 --> 01:07:33,730
THIS IS KEN AND DORIS WITH ME

1594
01:07:33,730 --> 01:07:36,299
AND THE GREAT ALAN LEHMAN, MY

1595
01:07:36,299 --> 01:07:39,802
COLLEAGUE FROM LONDON, AT THAT

1596
01:07:39,802 --> 01:07:41,571
MEETING, AT THE END OF A

1597
01:07:41,571 --> 01:07:44,874
TERRIFIC -- SO I NOW HAD A

1598
01:07:44,874 --> 01:07:45,575
MULTIDISCIPLINARY TEAM WHO I

1599
01:07:45,575 --> 01:07:47,844
DIDN'T KNOW THAT MUCH SO I KNEW

1600
01:07:47,844 --> 01:07:49,178
MORE THAN I'D KNOWN BEFORE ABOUT

1601
01:07:49,178 --> 01:07:52,515
XP AND HOW TO MANAGE IT, AND I

1602
01:07:52,515 --> 01:07:54,684
HAD MET -- WHERE SHOULD WE GO

1603
01:07:54,684 --> 01:07:56,986
FOR ADVICE, BUT REALLY ALL THE

1604
01:07:56,986 --> 01:08:01,291
KEY MEMBERS OF THE TEAM CAME

1605
01:08:01,291 --> 01:08:05,895
OVER, AND THE NURSES, DEBBY AND

1606
01:08:05,895 --> 01:08:08,197
TANYA AND PREDECESSOR CAME OVER

1607
01:08:08,197 --> 01:08:10,166
AND WERE HOSTED BEAUTIFULLY AT

1608
01:08:10,166 --> 01:08:11,568
THE NIH TO LEARN ABOUT AND TO

1609
01:08:11,568 --> 01:08:13,736
SEE KEN AND JOHN MANAGING THE

1610
01:08:13,736 --> 01:08:15,004
PATIENTS, HOW THEY MANAGE THE

1611
01:08:15,004 --> 01:08:16,539
PATIENTS, WHAT THEY DO, HOW TO

1612
01:08:16,539 --> 01:08:17,640
EXAMINE THE PATIENTS, HOW TO

1613
01:08:17,640 --> 01:08:20,476
TREAT THE PATIENTS.

1614
01:08:20,476 --> 01:08:22,178
AND WHAT WAS SO STRIKING WAS,

1615
01:08:22,178 --> 01:08:24,714
THIS WAS AT THE 2011, AGAIN, THE

1616
01:08:24,714 --> 01:08:29,085
XP MEETING, AAD, IN MIAMI, AND

1617
01:08:29,085 --> 01:08:30,687
THERE'S KEN AND JOHN AND DORIS

1618
01:08:30,687 --> 01:08:35,592
WITH MEMBERS OF MY TEAM, VARIOUS

1619
01:08:35,592 --> 01:08:38,027
MEMBERS OF MY TEAM AND WHAT WAS

1620
01:08:38,027 --> 01:08:39,963
SO STRIKING WAS THEIR GENEROSITY

1621
01:08:39,963 --> 01:08:41,264
WITH THEIR TIME, THEIR

1622
01:08:41,264 --> 01:08:42,465
GENEROSITY WITH THEIR EXPERTISE.

1623
01:08:42,465 --> 01:08:45,368
NOBODY ELSE KNEW THIS STUFF.

1624
01:08:45,368 --> 01:08:47,337
WHAT DO YOU DO ABOUT -- TO SORT

1625
01:08:47,337 --> 01:08:48,771
OUT OF SCALP OF SOMEBODY WITH

1626
01:08:48,771 --> 01:08:50,607
XP?

1627
01:08:50,607 --> 01:08:53,209
WHAT -- HOW DO YOU EXAMINE THESE

1628
01:08:53,209 --> 01:08:54,844
PATIENTS, WITH HUGE NUMBERS OF

1629
01:08:54,844 --> 01:08:55,278
TUMORS?

1630
01:08:55,278 --> 01:08:58,081
YOU KNOW, HOW DO YOU GET THE

1631
01:08:58,081 --> 01:08:59,282
OPHTHALMOLOGIST INVOLVED, ALL

1632
01:08:59,282 --> 01:09:01,017
THOSE SORT OF THINGS AND WE

1633
01:09:01,017 --> 01:09:03,820
JUST --  LAPPED IT UP, IT WAS

1634
01:09:03,820 --> 01:09:04,921
ABSOLUTELY WONDERFUL.

1635
01:09:04,921 --> 01:09:06,556
THINGS WENT VERY WELL FOR US AND

1636
01:09:06,556 --> 01:09:08,424
WE PAID THE COMPLIMENT BY

1637
01:09:08,424 --> 01:09:10,226
HOSTING THE SYMPOSIUM OURSELF,

1638
01:09:10,226 --> 01:09:11,761
BEING STRONG ENOUGH TO DO THAT

1639
01:09:11,761 --> 01:09:13,296
IN 2019, BUT I THINK ONE OF THE

1640
01:09:13,296 --> 01:09:14,897
BEST THINGS ABOUT THAT WAS THE

1641
01:09:14,897 --> 01:09:16,532
EVENING OUT THAT WE HAD, THIS IS

1642
01:09:16,532 --> 01:09:17,834
RIGHT AFTER END OF THE

1643
01:09:17,834 --> 01:09:19,168
CONFERENCE, WE HAD JUST PACKED

1644
01:09:19,168 --> 01:09:23,473
UP AND WE HAD AN EVENING OUT IN

1645
01:09:23,473 --> 01:09:24,674
LONDON.

1646
01:09:24,674 --> 01:09:28,411
 AFTER THAT.

1647
01:09:28,411 --> 01:09:32,649
SO I SUPPOSE ALL I CAN -- I CAN

1648
01:09:32,649 --> 01:09:35,885
THANK KEN AND DORIS AND ALSO

1649
01:09:35,885 --> 01:09:36,786
POSTHUMOUSLY THANK JOHN AND

1650
01:09:36,786 --> 01:09:38,755
DEBBY.

1651
01:09:38,755 --> 01:09:41,791
DEBBY, OF COURSE, SO WAS SO

1652
01:09:41,791 --> 01:09:43,926
HELPFUL TO OUR NURSES FOR REALLY

1653
01:09:43,926 --> 01:09:45,795
BEING -- PLAYING SUCH A MAJOR

1654
01:09:45,795 --> 01:09:49,532
ROLE IN IMPROVING THE CARE OF

1655
01:09:49,532 --> 01:09:51,868
PATIENTS WITH XP WHO LIVE IN THE

1656
01:09:51,868 --> 01:09:55,938
U.K., NO END, AND REALLY, KEN,

1657
01:09:55,938 --> 01:09:57,440
YOU'VE BEEN AN ABSOLUTELY

1658
01:09:57,440 --> 01:09:58,741
WONDERFUL COLLEAGUE, AND I'M

1659
01:09:58,741 --> 01:10:00,143
SORRY TO SEE YOU RETIRE.

1660
01:10:00,143 --> 01:10:03,646
I'M ALSO PLEASED FOR YOU AND

1661
01:10:03,646 --> 01:10:06,549
DORIS, SO I HOPE YOU HAVE A

1662
01:10:06,549 --> 01:10:07,116
WONDERFUL RETIREMENT.

1663
01:10:07,116 --> 01:10:07,984
THANK YOU FOR EVERYTHING.

1664
01:10:07,984 --> 01:10:16,859
[APPLAUSE]

1665
01:10:16,859 --> 01:10:17,827
>> THANK YOU, ROBERT.

1666
01:10:17,827 --> 01:10:21,397
NEXT UP, WE WILL HAVE A FEW

1667
01:10:21,397 --> 01:10:24,667
REMARKS FROM KEN'S SCIENCE

1668
01:10:24,667 --> 01:10:25,034
CHILDREN.

1669
01:10:25,034 --> 01:10:26,636
THESE ARE ALL KIDS FROM HIS LAB

1670
01:10:26,636 --> 01:10:28,004
WHO HAVE NOW GROWN UP AND NOW

1671
01:10:28,004 --> 01:10:29,205
HAVE THEIR OWN FAMILIES, I

1672
01:10:29,205 --> 01:10:30,640
SUPPOSE.

1673
01:10:30,640 --> 01:10:32,809
OR IN THE WAY OF ESTABLISHING

1674
01:10:32,809 --> 01:10:33,776
THEIR OWN FAMILIES.

1675
01:10:33,776 --> 01:10:39,148
SO FIRST UP IS STEFFEN EMMERT

1676
01:10:39,148 --> 01:10:39,782
FROM GERMANY.

1677
01:10:39,782 --> 01:10:40,583
GO AHEAD, PLEASE.

1678
01:10:40,583 --> 01:10:42,685
>> HELLO.

1679
01:10:42,685 --> 01:10:44,087
I HOPE YOU CAN HEAR ME AND I'D

1680
01:10:44,087 --> 01:10:53,062
ALSO LIKE TO SHARE SOME SLIDES.

1681
01:10:53,062 --> 01:10:55,865
SO GOOD AFTERNOON, EVERYBODY.

1682
01:10:55,865 --> 01:10:59,035
AND DEAR KEN AND DEAR DORIS.

1683
01:10:59,035 --> 01:11:00,903
THANKS VERY MUCH FOR THE

1684
01:11:00,903 --> 01:11:02,205
INVITATION, AND OF COURSE FOR

1685
01:11:02,205 --> 01:11:05,441
THE OPPORTUNITY TO SPEND A FEW

1686
01:11:05,441 --> 01:11:07,977
WORDS ON YOUR OCCASION OF YOUR

1687
01:11:07,977 --> 01:11:10,046
RETIREMENT.

1688
01:11:10,046 --> 01:11:11,781
THIS IS REALLY A GREAT HONOR FOR

1689
01:11:11,781 --> 01:11:15,251
ME, HOWEVER, THIS IS ALSO A BIG

1690
01:11:15,251 --> 01:11:17,053
CESSATION IN DNA REPAIR RESEARCH

1691
01:11:17,053 --> 01:11:19,956
IN GENERAL.

1692
01:11:19,956 --> 01:11:25,828
SO THIS IS OF COURSE THE KRAEMER

1693
01:11:25,828 --> 01:11:27,897
LAB OVER THE LAST 50 YEARS OR

1694
01:11:27,897 --> 01:11:30,299
SO, DNA TRANSLATIONAL RESEARCH

1695
01:11:30,299 --> 01:11:31,901
AROUND THE WORLD, SO THIS MEANS

1696
01:11:31,901 --> 01:11:34,837
REALLY ALWAYS FOCUSING ON THE

1697
01:11:34,837 --> 01:11:38,875
NEEDS OF THEIR PATIENTS, WE'VE

1698
01:11:38,875 --> 01:11:41,911
HEARD ALREADY FROM MICHELE

1699
01:11:41,911 --> 01:11:43,579
MILOTA AND THE SUPPORT GROUPS,

1700
01:11:43,579 --> 01:11:47,850
SSO THE LAB TO THE BENCH AND BAK

1701
01:11:47,850 --> 01:11:49,418
TO THE PATIENTS, THIS IS HOW IT

1702
01:11:49,418 --> 01:11:50,853
SHOULD BE.

1703
01:11:50,853 --> 01:11:52,522
YOU ORGANIZED THE FIRST

1704
01:11:52,522 --> 01:11:55,458
INTERNATIONAL XP WORKSHOP IN

1705
01:11:55,458 --> 01:11:57,160
2006 AT NIH.

1706
01:11:57,160 --> 01:11:59,128
AND IF YOU CAN SEE MY CURSOR

1707
01:11:59,128 --> 01:12:03,699
DOWN HERE, THIS IS THOMAS, YOUR

1708
01:12:03,699 --> 01:12:05,434
FIRST GERMAN POSTDOC, HE WAS

1709
01:12:05,434 --> 01:12:07,203
ALSO PRESENT IN THIS MEETING,

1710
01:12:07,203 --> 01:12:10,139
AND HE WAS MY DOCTORAL FATHER.

1711
01:12:10,139 --> 01:12:13,810
AND THEN HE ORGANIZED, 10 YEARS

1712
01:12:13,810 --> 01:12:16,112
LATER, MY STAY IN YOUR LAB AS

1713
01:12:16,112 --> 01:12:18,514
THE SECOND GENERATION OF GERMAN

1714
01:12:18,514 --> 01:12:23,152
POSTDOCS UNTIL THE MILLENNIUM

1715
01:12:23,152 --> 01:12:26,255
CHANGED IN 2000.

1716
01:12:26,255 --> 01:12:27,456
WELL, AND ALREADY MENTIONED THIS

1717
01:12:27,456 --> 01:12:30,159
SECOND MEETING, YOU ORGANIZED

1718
01:12:30,159 --> 01:12:30,693
THE SECOND INTERNATIONAL

1719
01:12:30,693 --> 01:12:35,064
WORKSHOP ON XP IN 2010.

1720
01:12:35,064 --> 01:12:39,068
AND ALWAYS, AND TH THIS HAS ALRY

1721
01:12:39,068 --> 01:12:40,069
BEEN MENTIONED, WITH YOUR WIFE

1722
01:12:40,069 --> 01:12:41,704
DORIS, AND IF I SHOULD SAY THE

1723
01:12:41,704 --> 01:12:45,641
SAME AS MY WIFE -- HERE IN

1724
01:12:45,641 --> 01:12:48,110
GERMANY, SO A ROLE MODEL FOR

1725
01:12:48,110 --> 01:12:50,413
OTHER PEOPLE.

1726
01:12:50,413 --> 01:12:53,916
SO HERE, HE WAS A DOCTORAL

1727
01:12:53,916 --> 01:12:55,985
STUDENT OF MY LAB IN GERMANY,

1728
01:12:55,985 --> 01:12:57,587
AND REPRESENTS THE THIRD

1729
01:12:57,587 --> 01:12:59,288
GENERATION OF GERMAN POSTDOCS IN

1730
01:12:59,288 --> 01:13:01,724
YOUR LAB.

1731
01:13:01,724 --> 01:13:04,760
SO A REALLY GREAT LINE OF

1732
01:13:04,760 --> 01:13:07,597
POSTDOCS.

1733
01:13:07,597 --> 01:13:10,266
SO CAN YOU TRULY SAY A GREAT

1734
01:13:10,266 --> 01:13:13,836
TEAM, YOUR TEAM, THE KRAEMER

1735
01:13:13,836 --> 01:13:16,639
LAB, NEW GENERATIONS, AT LEAST

1736
01:13:16,639 --> 01:13:19,375
TRY TO CONTINUE ONE WAY OR THE

1737
01:13:19,375 --> 01:13:21,577
OTHER.

1738
01:13:21,577 --> 01:13:24,313
THERE IS A NEW GENERATION IN

1739
01:13:24,313 --> 01:13:30,253
ISRAEL AROUND -- DNA REPAIR

1740
01:13:30,253 --> 01:13:33,256
RESEARCH, AND THERE IS A NEW

1741
01:13:33,256 --> 01:13:35,892
GENERATION IN JAPAN THAT

1742
01:13:35,892 --> 01:13:37,260
ORGANIZED THE THIRD

1743
01:13:37,260 --> 01:13:43,266
INTERNATIONAL XP MEETING IN 2014

1744
01:13:43,266 --> 01:13:48,704
WITH PROFESSOR NISHIKORI AND

1745
01:13:48,704 --> 01:13:55,077
PROFESSOR MORIBACKE, MY

1746
01:13:55,077 --> 01:13:56,812
POSTDOCTORAL PREDECESSOR IN YOUR

1747
01:13:56,812 --> 01:14:03,252
LAB IN 1997.

1748
01:14:03,252 --> 01:14:04,553
SO THEN I WAS REALLY GLAD THAT

1749
01:14:04,553 --> 01:14:09,592
YOU WERE ABLE TO COME TO GERMANY

1750
01:14:09,592 --> 01:14:11,627
IN 2016, WHEN I STARTED AS

1751
01:14:11,627 --> 01:14:14,497
DIRECTOR OF THE DERM CLINIC

1752
01:14:14,497 --> 01:14:19,535
THERE TOGETHER WITH DR. JOHN

1753
01:14:19,535 --> 01:14:20,803
DICHUWANI WHO ALREADY SAID HE

1754
01:14:20,803 --> 01:14:23,205
PASSED AWAY THE LAST YEAR AND

1755
01:14:23,205 --> 01:14:27,877
JOHN IS REALLY MISSED.

1756
01:14:27,877 --> 01:14:31,480
AND THE LAST TIME WE MET WAS AT

1757
01:14:31,480 --> 01:14:33,683
AN ORGANIZATION MEETING OF THE

1758
01:14:33,683 --> 01:14:35,751
FOURTH INTERNATIONAL XP MEETING

1759
01:14:35,751 --> 01:14:40,623
IN 2019 IN CAMBRIDGE, SO I ALSO

1760
01:14:40,623 --> 01:14:44,126
IS SALUTE TO DEBBY, THE JAPANESE

1761
01:14:44,126 --> 01:14:44,894
COLLEAGUES, AND THIS WAS THE

1762
01:14:44,894 --> 01:14:46,329
LAST WORLD MEETING ON DNA

1763
01:14:46,329 --> 01:14:48,397
REPAIR.

1764
01:14:48,397 --> 01:14:52,601
WELL, AND YOU AND JOHN CONTINUE

1765
01:14:52,601 --> 01:14:55,805
TO INSPIRE YOUNG INNOVATIONS, WE

1766
01:14:55,805 --> 01:14:57,606
HEARD ALREADY FROM THE SID

1767
01:14:57,606 --> 01:15:03,980
MEETINGS, SO YOU TOGETHER WITH

1768
01:15:03,980 --> 01:15:08,017
JOHN DOWN HERE GAVE THE --

1769
01:15:08,017 --> 01:15:11,420
ADDRESS IN 2022, WHEN WE HOST

1770
01:15:11,420 --> 01:15:14,757
AROUND 30 AMERICAN STUDENTS

1771
01:15:14,757 --> 01:15:15,825
MAINLY FROM BROWN UNIVERSITY BUT

1772
01:15:15,825 --> 01:15:21,964
ALSO OTHER PLACES OF THE U.S.

1773
01:15:21,964 --> 01:15:29,138
SO DEAR KEN, DEAR DORIS, KEEP ON

1774
01:15:29,138 --> 01:15:30,373
SAILING AND INSPIRING NEW

1775
01:15:30,373 --> 01:15:32,541
GENERATIONS OF RESEARCHERS AND

1776
01:15:32,541 --> 01:15:34,276
WE LOOK FORWARD TO WELCOMING YOU

1777
01:15:34,276 --> 01:15:38,080
TO THE FIFTH INTERNATIONAL XP

1778
01:15:38,080 --> 01:15:39,949
SYMPOSIUM JUST ABOUT TO ORGANIZE

1779
01:15:39,949 --> 01:15:43,386
HERE IN GERMANY WHICH WILL START

1780
01:15:43,386 --> 01:15:46,255
IN FEBRUARY 2025.

1781
01:15:46,255 --> 01:15:49,759
SO MY WIFE AND I WISH YOU BOTH,

1782
01:15:49,759 --> 01:15:51,994
KEN AND DORIS AND OF COURSE YOUR

1783
01:15:51,994 --> 01:15:56,065
FOUR CHILDREN ALL THE BEST.

1784
01:15:56,065 --> 01:15:57,466
WE HOPE TO SEE YOU SOON.

1785
01:15:57,466 --> 01:16:00,569
THANK YOU.

1786
01:16:00,569 --> 01:16:08,010
[APPLAUSE]

1787
01:16:08,010 --> 01:16:10,246
>> THANK YOU VERY MUCH,
STEFFEN.

1788
01:16:10,246 --> 01:16:12,982
NEXT I WOULD LIKE TO INVITE ALAN

1789
01:16:12,982 --> 01:16:15,885
ZHOU FROM CHICAGO.

1790
01:16:15,885 --> 01:16:17,987
ALAN WAS A POSTDOC WITH KEN, AND

1791
01:16:17,987 --> 01:16:22,625
NOW A DERMATOLOGIST.

1792
01:16:22,625 --> 01:16:24,894
>> CAN YOU GUYS HEAR ME
OKAY?

1793
01:16:24,894 --> 01:16:25,728
>> YES, WE CAN.

1794
01:16:25,728 --> 01:16:27,797
GO AHEAD, PLEASE.

1795
01:16:27,797 --> 01:16:28,130
>> YES.

1796
01:16:28,130 --> 01:16:29,999
I REALLY WISH I COULD BE THERE

1797
01:16:29,999 --> 01:16:33,469
TODAY, BUT I'M IN SAN DIEGO FOR

1798
01:16:33,469 --> 01:16:35,304
THE AAD MEETING THIS YEAR.

1799
01:16:35,304 --> 01:16:36,305
I JUST WANTED TO SHARE A LITTLE

1800
01:16:36,305 --> 01:16:36,639
BIT.

1801
01:16:36,639 --> 01:16:40,109
I JOINED DR. KRAEMER'S LAB IN

1802
01:16:40,109 --> 01:16:45,748
2009, 2010, AND I WAS AN NIH CRT

1803
01:16:45,748 --> 01:16:47,083
FELLOW AND AT THE TIME I WAS A

1804
01:16:47,083 --> 01:16:48,150
MEDICAL STUDENT AT DUKE AND I

1805
01:16:48,150 --> 01:16:50,019
WAS JUST SO LOST AS TO WHAT MY

1806
01:16:50,019 --> 01:16:52,321
FUTURE CAREER WAS GOING TO BE.

1807
01:16:52,321 --> 01:16:54,156
THERE ARE SO MANY DIFFERENT

1808
01:16:54,156 --> 01:16:55,491
SPECIALTIES IN MEDICINE.

1809
01:16:55,491 --> 01:16:57,226
I HAD NO IDEA WHAT I WAS GOING

1810
01:16:57,226 --> 01:16:57,993
TO DO.

1811
01:16:57,993 --> 01:16:59,829
BUT HERE I GOT TO SPEND SOME

1812
01:16:59,829 --> 01:17:02,898
TIME AND SEE WHAT YOU AND DR. D

1813
01:17:02,898 --> 01:17:05,701
GOT TO DO IN MAKING DISCOVERIES

1814
01:17:05,701 --> 01:17:06,268
WITHIN DERMATOLOGY.

1815
01:17:06,268 --> 01:17:11,040
YOU REALLY -- REALLY SHOWED HOW

1816
01:17:11,040 --> 01:17:14,376
TO DO THIS BEDSIDE TO BENCH TO

1817
01:17:14,376 --> 01:17:16,412
BEDSIDE MODEL.

1818
01:17:16,412 --> 01:17:19,014
SO I DECIDED TO BECOME A

1819
01:17:19,014 --> 01:17:21,217
DERMATOLOGIST AND A PHYSICIAN

1820
01:17:21,217 --> 01:17:22,251
RESEARCHER, AND EVEN IN THE PAST

1821
01:17:22,251 --> 01:17:23,919
FEW WEEKS, WE HAVE STILL BEEN

1822
01:17:23,919 --> 01:17:28,057
CONSULTING WITH YOU AND ABOUT

1823
01:17:28,057 --> 01:17:30,593
OUR CURRENT XP PATIENTS SO I

1824
01:17:30,593 --> 01:17:31,894
REALLY OWE YOU IN HELPING ME

1825
01:17:31,894 --> 01:17:33,195
FIND DIRECTION AT A TIME WHEN I

1826
01:17:33,195 --> 01:17:34,530
WAS LOST, AND FOR SHOWING ME

1827
01:17:34,530 --> 01:17:39,068
THAT, YOU  THE MANY DISCOVERIEST

1828
01:17:39,068 --> 01:17:40,402
CAN BE MADE WITHIN DERMATOLOGY

1829
01:17:40,402 --> 01:17:41,704
AND LEARNING FROM THE GENETICS

1830
01:17:41,704 --> 01:17:43,105
OF AN INDIVIDUAL.

1831
01:17:43,105 --> 01:17:44,640
BUT YOU KNOW, MORE IMPORTANTLY,

1832
01:17:44,640 --> 01:17:46,275
I REALLY WANT TO THANK YOU FOR

1833
01:17:46,275 --> 01:17:48,878
THE KINDNESS YOU HAVE SHOWN MEL.

1834
01:17:48,878 --> 01:17:51,147
YOU'VE ALWAYS TREATED ME AS

1835
01:17:51,147 --> 01:17:52,815
FAMILY, AS ANOTHER FATHER TO ME,

1836
01:17:52,815 --> 01:17:54,250
AND I ALWAYS LOOK FORWARD TO

1837
01:17:54,250 --> 01:17:56,819
SEEING YOU AT THE DERM MEETINGS.

1838
01:17:56,819 --> 01:17:58,554
YOU KNOW, IMPORTANTLY, YOU'VE

1839
01:17:58,554 --> 01:18:00,956
SHOWN ME HOW TO BE A GOOD,

1840
01:18:00,956 --> 01:18:02,691
CARING PERSON, NOT JUST TO YOUR

1841
01:18:02,691 --> 01:18:04,894
PATIENTS, BUT TO COLLEAGUES,

1842
01:18:04,894 --> 01:18:06,428
STUDENTS, AND EVEN STRANGERS.

1843
01:18:06,428 --> 01:18:09,465
SO I REALLY WISH YOU AND DORIS

1844
01:18:09,465 --> 01:18:11,333
THE BEST RETIREMENT, AND I

1845
01:18:11,333 --> 01:18:13,502
REALLY HOPE TO BE ABLE TO SEE

1846
01:18:13,502 --> 01:18:16,472
YOU AGAIN SOON IN THE FUTURE.

1847
01:18:16,472 --> 01:18:23,779
[APPLAUSE]

1848
01:18:23,779 --> 01:18:25,414
>> THANK YOU, ALAN.

1849
01:18:25,414 --> 01:18:28,250
NEXT I THINK WE HAVE A SHORT

1850
01:18:28,250 --> 01:18:38,727
VIDEO FROM SALMA DE LA FELD.

1851
01:18:43,832 --> 01:18:44,733
>> HI, EVERYONE.

1852
01:18:44,733 --> 01:18:48,671
MY NAME IS DR. SALMA DE LA FELD,

1853
01:18:48,671 --> 01:18:49,972
AND I'M A DERMATOLOGIST AT

1854
01:18:49,972 --> 01:18:50,506
EMORY.

1855
01:18:50,506 --> 01:18:53,042
ONE OF THE BEST THINGS THAT HAS

1856
01:18:53,042 --> 01:18:54,643
EVER HAPPENED TO ME IN MY LIFE

1857
01:18:54,643 --> 01:18:55,744
IS HAVING THE OPPORTUNITY TO

1858
01:18:55,744 --> 01:18:58,681
HAVE DR. KRAEMER AS MY MENTOR.

1859
01:18:58,681 --> 01:19:00,516
I FIRST MET DR. KRAEMER THE

1860
01:19:00,516 --> 01:19:02,484
SUMMER BEFORE I STARTED MEDICAL

1861
01:19:02,484 --> 01:19:04,119
SCHOOL, WHEN HE TOOK ME UNDER

1862
01:19:04,119 --> 01:19:06,488
HIS WING TO WORK IN HIS LAB.

1863
01:19:06,488 --> 01:19:09,325
WHAT STARTED AS A SUMMER

1864
01:19:09,325 --> 01:19:10,426
RESEARCH PROJECT TURNED INTO A

1865
01:19:10,426 --> 01:19:13,462
LIFETIME OF MENTORSHIP.

1866
01:19:13,462 --> 01:19:15,097
DR. KRAEMER, YOU CHANGED MY

1867
01:19:15,097 --> 01:19:15,297
LIFE.

1868
01:19:15,297 --> 01:19:17,066
I WOULDN'T BE A DERMATOLOGIST IF

1869
01:19:17,066 --> 01:19:18,901
IT WEREN'T FOR EVERYTHING THAT

1870
01:19:18,901 --> 01:19:21,303
YOU AND DR. D DID FOR ME.

1871
01:19:21,303 --> 01:19:23,939
YOU TAUGHT ME SO MUCH ABOUT

1872
01:19:23,939 --> 01:19:26,575
MEDICINE, RESEARCH, AND PATIENT

1873
01:19:26,575 --> 01:19:27,943
CARE BEFORE I EVEN STEPPED FOOT

1874
01:19:27,943 --> 01:19:30,679
IN THE MEDICAL SCHOOL.

1875
01:19:30,679 --> 01:19:32,548
THANK YOU, DR. KRAEMER, FOR

1876
01:19:32,548 --> 01:19:35,150
BEING AN INCREDIBLE MENTOR, AND

1877
01:19:35,150 --> 01:19:37,786
FOR BEING SO ENCOURAGING AND

1878
01:19:37,786 --> 01:19:38,854
APPROACHABLE.

1879
01:19:38,854 --> 01:19:41,790
THANK YOU FOR BELIEVING IN ME.

1880
01:19:41,790 --> 01:19:45,027
I WILL ALWAYS REMEMBER WHEN YOU

1881
01:19:45,027 --> 01:19:47,596
FIRST ASKED ME TO PRESENT A CASE

1882
01:19:47,596 --> 01:19:50,266
AT NIH GRAND ROUNDS.

1883
01:19:50,266 --> 01:19:52,368
I WAS NERVOUS, BUT YOU BELIEVED

1884
01:19:52,368 --> 01:19:54,136
IN ME, AND YOU TOLD ME THAT YOU

1885
01:19:54,136 --> 01:19:55,971
KNEW I'D DO GREAT.

1886
01:19:55,971 --> 01:19:57,406
AND YOU'VE ALWAYS BEEN SO

1887
01:19:57,406 --> 01:19:59,575
SUPPORTIVE AND ENCOURAGING.

1888
01:19:59,575 --> 01:20:01,210
THANK YOU FOR MAKING ME FEEL

1889
01:20:01,210 --> 01:20:03,379
LIKE I COULD MAKE A DIFFERENCE,

1890
01:20:03,379 --> 01:20:06,015
AND FOR MAKING THE STUDY OF

1891
01:20:06,015 --> 01:20:08,050
MEDICINE BEING LESS

1892
01:20:08,050 --> 01:20:08,417
INTIMIDATING.

1893
01:20:08,417 --> 01:20:09,918
I REMEMBER THE FIRST TIME YOU

1894
01:20:09,918 --> 01:20:12,421
EVER SHOWED ME TIGRR TAIL

1895
01:20:12,421 --> 01:20:13,856
BANDING UNDER THE MICROSCOPE,

1896
01:20:13,856 --> 01:20:16,292
AND YOU SAID, SEE, ANYONE CAN

1897
01:20:16,292 --> 01:20:17,593
LOOK AT THE HAIR UNDER THE

1898
01:20:17,593 --> 01:20:18,327
MICROSCOPE AND MAKE THIS

1899
01:20:18,327 --> 01:20:21,230
DIAGNOSIS.

1900
01:20:21,230 --> 01:20:24,199
AND EVERY YEAR THAT I'VE MADE TO

1901
01:20:24,199 --> 01:20:26,702
AAV, I HAVE ALWAYS ENJOYED GOING

1902
01:20:26,702 --> 01:20:28,971
TO THE SATURDAY LUNCH SESSION ON

1903
01:20:28,971 --> 01:20:32,374
XP AND TTD.

1904
01:20:32,374 --> 01:20:34,209
AND EVERY YEAR I'VE MET MORE

1905
01:20:34,209 --> 01:20:36,712
PEOPLE WHOM DR. KRAEMER HAS

1906
01:20:36,712 --> 01:20:38,681
TAKEN UNDER HIS WING, THE SAME

1907
01:20:38,681 --> 01:20:41,417
WAY HE DID FOR ME.

1908
01:20:41,417 --> 01:20:44,453
AND SO, DOCTOR, YOU HAVE DONE SO

1909
01:20:44,453 --> 01:20:47,056
MUCH FOR ALL THE REST OF US, DRO

1910
01:20:47,056 --> 01:20:48,557
WISH YOU ALL OF THE BEST THINGS

1911
01:20:48,557 --> 01:20:50,426
FOR RETIREMENT.

1912
01:20:50,426 --> 01:20:52,494
A HUGE CONGRATULATIONS ON YOUR

1913
01:20:52,494 --> 01:20:54,263
RETIREMENT, DR. KRAEMER.

1914
01:20:54,263 --> 01:20:57,399
AND A HUGE THANK YOU FROM ME AND

1915
01:20:57,399 --> 01:20:59,702
FROM ALL OF THE PEOPLE WHOSE

1916
01:20:59,702 --> 01:21:00,602
LIVES YOU HAVE CHANGED.

1917
01:21:00,602 --> 01:21:02,438
THANK YOU.

1918
01:21:02,438 --> 01:21:11,714
[APPLAUSE]

1919
01:21:11,714 --> 01:21:14,583
>> OKAY.

1920
01:21:14,583 --> 01:21:17,486
WE HAVE MAYBE 10 MORE?

1921
01:21:17,486 --> 01:21:19,154
NO, JUST KIDDING.

1922
01:21:19,154 --> 01:21:19,855
[LAUGHTER]

1923
01:21:19,855 --> 01:21:22,958
SO NEXT WE'D LIKE TO INVITE

1924
01:21:22,958 --> 01:21:27,196
JENNIFER PUGH.

1925
01:21:27,196 --> 01:21:31,467
SHE WAS A TRAINEE AND NOW A DERM

1926
01:21:31,467 --> 01:21:34,103
RESIDENT AT WASH-U.

1927
01:21:34,103 --> 01:21:35,371
>> HELLO, EVERYONE.

1928
01:21:35,371 --> 01:21:37,673
I WISH I COULD BE THERE IN

1929
01:21:37,673 --> 01:21:39,074
PERSON TODAY.

1930
01:21:39,074 --> 01:21:41,810
BUT MY NAME IS JENNIFER PUGH.

1931
01:21:41,810 --> 01:21:47,716
I'M A FORMER POSTB POSTBAC FRO.

1932
01:21:47,716 --> 01:21:48,617
DR. KRAEMER'S LAB.

1933
01:21:48,617 --> 01:21:49,651
ONE THING ABOUT GOING TOWARDS

1934
01:21:49,651 --> 01:21:50,986
THE END IS EVERYONE HAS SAID ALL

1935
01:21:50,986 --> 01:21:52,521
THE AMAZING THINGS ABOUT

1936
01:21:52,521 --> 01:21:53,856
DR. KRAEMER SO FAR, AND HIS

1937
01:21:53,856 --> 01:21:56,225
IMPACT.

1938
01:21:56,225 --> 01:21:57,526
SO I HAD THE PRIVILEGE OF

1939
01:21:57,526 --> 01:22:00,496
WORKING WITH DR. KRAEMER FOR

1940
01:22:00,496 --> 01:22:03,732
THREE YEARS AFTER UNDERGRAD FROM

1941
01:22:03,732 --> 01:22:06,268
2015 TO 2018, AFTER WHICH I WENT

1942
01:22:06,268 --> 01:22:10,205
TO MEDICAL SCHOOL AND THEN ON TO

1943
01:22:10,205 --> 01:22:13,041
DERMATOLOGY RESIDENCY AT WASH-U

1944
01:22:13,041 --> 01:22:14,443
IN ST. LOUIS, WHERE I AM

1945
01:22:14,443 --> 01:22:16,311
CURRENTLY.

1946
01:22:16,311 --> 01:22:19,181
TODAY, I REALLY JUST WANT TO

1947
01:22:19,181 --> 01:22:21,784
EXPRESS MY GRATITUDE FOR ALL

1948
01:22:21,784 --> 01:22:24,286
THAT YOU HAVE DONE, DR. KRAEMER,

1949
01:22:24,286 --> 01:22:26,889
AND ECHO MUCH OF WHAT HAS BEEN

1950
01:22:26,889 --> 01:22:28,957
SAID BY THE SPEAKERS TODAY.

1951
01:22:28,957 --> 01:22:33,095
THANK YOU SO MUCH FOR BEING SO

1952
01:22:33,095 --> 01:22:36,165
DEDICATED TO SCIENCE AND THE

1953
01:22:36,165 --> 01:22:37,699
BETTERMENT OF PATIENTS' QUALITY

1954
01:22:37,699 --> 01:22:39,334
AND QUANTITY OF LIFE.

1955
01:22:39,334 --> 01:22:41,537
THANK YOU FOR BEING SO DEDICATED

1956
01:22:41,537 --> 01:22:43,138
TO FOSTERING OPPORTUNITIES FOR

1957
01:22:43,138 --> 01:22:45,207
THE NEXT GENERATION OF

1958
01:22:45,207 --> 01:22:47,075
PHYSICIANS AND SCIENTISTS.

1959
01:22:47,075 --> 01:22:49,678
THANK YOU FOR CREATING A LAB

1960
01:22:49,678 --> 01:22:51,880
CULTURE CENTERED AROUND KINDNESS

1961
01:22:51,880 --> 01:22:53,282
AND INCLUSIVITY.

1962
01:22:53,282 --> 01:22:56,452
THANK YOU FOR CHALLENGING ME

1963
01:22:56,452 --> 01:22:57,553
INTELLECTUALLY, MAKING SURE WE

1964
01:22:57,553 --> 01:23:00,055
ATTENDED ALL THE LAB MEETINGS,

1965
01:23:00,055 --> 01:23:01,457
ALL THE DNA REPAIR INTEREST

1966
01:23:01,457 --> 01:23:04,293
GROUP MEETINGS, STAYED INFORMED

1967
01:23:04,293 --> 01:23:06,161
ABOUT ONGOING LAB PROJECTS, EVEN

1968
01:23:06,161 --> 01:23:08,464
THE ONES THAT WEREN'T OUR OWN,

1969
01:23:08,464 --> 01:23:09,898
AND SAW ALL THE PATIENTS IN THE

1970
01:23:09,898 --> 01:23:10,966
CLINICAL CENTER.

1971
01:23:10,966 --> 01:23:13,235
THANK YOU FOR MAKING SURE WE

1972
01:23:13,235 --> 01:23:15,437
MADE TO ALL THE CONFERENCES AND

1973
01:23:15,437 --> 01:23:18,073
ALWAYS PRESENTED OUR WORK.

1974
01:23:18,073 --> 01:23:20,342
IF YOU KNOW DR. KRAEMER, HE WILL

1975
01:23:20,342 --> 01:23:22,110
HAVE YOU SPEAK AT ANYTHING THAT

1976
01:23:22,110 --> 01:23:23,846
HE'S INVOLVED IN IF YOU HAVE

1977
01:23:23,846 --> 01:23:24,947
SOMETHING THAT'S RELEVANT, HE

1978
01:23:24,947 --> 01:23:27,316
WILL HAVE YOU PRESENT THERE, AND

1979
01:23:27,316 --> 01:23:29,418
I REALLY APPRECIATE THAT BECAUSE

1980
01:23:29,418 --> 01:23:33,021
I FEEL LIKE IT PREPARED ME FOR

1981
01:23:33,021 --> 01:23:35,858
JUST BEING ABLE TO SPEAK ABOUT

1982
01:23:35,858 --> 01:23:37,259
MY SCIENTIFIC DISCOVERIES AND

1983
01:23:37,259 --> 01:23:40,229
JUST GETTING TO KNOW DIFFERENT

1984
01:23:40,229 --> 01:23:42,197
PEOPLE AND HONING THAT

1985
01:23:42,197 --> 01:23:43,599
COMMUNICATION SKILL.

1986
01:23:43,599 --> 01:23:46,768
SO THANK YOU FOR EVERY PAPER,

1987
01:23:46,768 --> 01:23:48,504
POWERPOINT, MEDICAL SCHOOL

1988
01:23:48,504 --> 01:23:50,372
APPLICATION, RESIDENCY

1989
01:23:50,372 --> 01:23:52,007
APPLICATION.

1990
01:23:52,007 --> 01:23:52,908
 YOU READ AND

1991
01:23:52,908 --> 01:23:54,276
PROVIDED YOUR HONEST FEEDBACK,

1992
01:23:54,276 --> 01:23:56,144
AND YES, I'M STILL WORKING ON

1993
01:23:56,144 --> 01:24:00,516
CUTTING BACK THE FLOWERY

1994
01:24:00,516 --> 01:24:00,849
LANGUAGE.

1995
01:24:00,849 --> 01:24:03,785
THANK YOU FOR INVITING US TO

1996
01:24:03,785 --> 01:24:07,055
EVENTS AT THE SIN G SYNAGOGUE, E

1997
01:24:07,055 --> 01:24:08,257
MAGNETS YOU BROUGHT US BACK FROM

1998
01:24:08,257 --> 01:24:15,464
YOUR TRAVELS, THE REREESES AND

1999
01:24:15,464 --> 01:24:16,465
M & Ms, YOU KNOW THERE'S A

2000
01:24:16,465 --> 01:24:17,332
BOWL IN THE FRONT.

2001
01:24:17,332 --> 01:24:19,101
THE SUMMER COOKOUTS, THE END OF

2002
01:24:19,101 --> 01:24:21,136
THE YEAR LAB DINNERS, AND OH,

2003
01:24:21,136 --> 01:24:22,571
OUR FRIENDLY COMPETITION WITH

2004
01:24:22,571 --> 01:24:24,406
OUR DAILY STEP COUNT, WHICH I'M

2005
01:24:24,406 --> 01:24:25,474
SURE YOU'RE PROBABLY IN THE LEAD

2006
01:24:25,474 --> 01:24:28,043
NOW.

2007
01:24:28,043 --> 01:24:30,312
AND JUST THANK YOU FOR ALL THE

2008
01:24:30,312 --> 01:24:33,515
YEARS AND ALL THE TIME, ALL THE

2009
01:24:33,515 --> 01:24:35,450
ENERGY, AND THE WORK YOU HAVE

2010
01:24:35,450 --> 01:24:35,684
DONE.

2011
01:24:35,684 --> 01:24:37,786
YOU HAVE TRULY BEEN MORE THAN A

2012
01:24:37,786 --> 01:24:38,320
MENTOR.

2013
01:24:38,320 --> 01:24:40,389
YOU ARE LIKE FAMILY.

2014
01:24:40,389 --> 01:24:41,924
AND MY PARENT ACTUALLY WANTED TO

2015
01:24:41,924 --> 01:24:45,193
LISTEN IN ON THE RETIREMENT

2016
01:24:45,193 --> 01:24:46,161
EVENT SO THEY'RE ON HERE AS

2017
01:24:46,161 --> 01:24:50,265
WELL.

2018
01:24:50,265 --> 01:24:53,035
I'M WISHING YOU ALL THE BEST AND

2019
01:24:53,035 --> 01:24:55,671
HOPING THIS IS A PHENOMENON

2020
01:24:55,671 --> 01:25:00,275
IALNEXT CHAPTER OF LIFE FOR YOU.

2021
01:25:00,275 --> 01:25:01,677
I ALSO HAVE A FEW SLIDES I MADE

2022
01:25:01,677 --> 01:25:02,878
AND I WOULD LIKE TO SHARE, SO

2023
01:25:02,878 --> 01:25:04,379
I'M GOING TO SHARE MY SCREEN

2024
01:25:04,379 --> 01:25:14,623
NOW, IF I CAN.

2025
01:25:18,360 --> 01:25:20,128
I'M A MILLENNIAL BUT I'M STILL A

2026
01:25:20,128 --> 01:25:27,536
LITTLE SLOW AT TECHNOLOGY, SO --

2027
01:25:27,536 --> 01:25:37,646
OKAY.

2028
01:26:18,487 --> 01:26:21,423
>> SHE MAY BE ON A MAC SO
IT MAY

2029
01:26:21,423 --> 01:26:23,158
HAVE FORCED HER TO REBOOT HER

2030
01:26:23,158 --> 01:26:25,527
COMPUTER.

2031
01:26:25,527 --> 01:26:27,029
>> YEAH, SHE'S NOT IN THE
ROOM,

2032
01:26:27,029 --> 01:26:27,996
IN THE MEETING RIGHT NOW.

2033
01:26:27,996 --> 01:26:31,299
>> OKAY.

2034
01:26:31,299 --> 01:26:32,834
>> WELL, THAT WAS
BEAUTIFUL.

2035
01:26:32,834 --> 01:26:34,036
LISTENING TO HER MAKES ME

2036
01:26:34,036 --> 01:26:34,403
JEALOUS.

2037
01:26:34,403 --> 01:26:36,405
I WISH I WAS A POSTDOC IN YOUR

2038
01:26:36,405 --> 01:26:40,042
LAB.

2039
01:26:40,042 --> 01:26:42,210
NEXT I WOULD LIKE TO INVITE DOUG

2040
01:26:42,210 --> 01:26:43,445
LOWY, A MAN WHO NEEDS NO

2041
01:26:43,445 --> 01:26:44,846
INTRODUCTION FOR US.

2042
01:26:44,846 --> 01:26:45,781
DOUG IS GOING TO PRESENT

2043
01:26:45,781 --> 01:26:46,915
SOMETHING TO KEN AND THEN SAY A

2044
01:26:46,915 --> 01:26:57,092
FEW WORDS.

2045
01:26:57,359 --> 01:26:58,827
>> SO I STAND BETWEEN YOU
AND

2046
01:26:58,827 --> 01:27:01,630
KEN MAKING REMARKS.

2047
01:27:01,630 --> 01:27:03,165
AN ENVIABLE POSITION.

2048
01:27:03,165 --> 01:27:05,033
KEN, I THOUGHT THAT THIS WAS

2049
01:27:05,033 --> 01:27:08,503
GOING TO BE EVEN BIGGER, BUT I

2050
01:27:08,503 --> 01:27:10,706
HOPE THAT YOU APPRECIATE THIS.

2051
01:27:10,706 --> 01:27:13,308
IT IS NOT A MEASURE OF YOUR

2052
01:27:13,308 --> 01:27:14,009
ACCOMPLISHMENTS.

2053
01:27:14,009 --> 01:27:17,479
IT IS A SUBSET OF THEM.

2054
01:27:17,479 --> 01:27:20,982
WE ARE SO PROUD OF ALL THAT YOU

2055
01:27:20,982 --> 01:27:25,554
HAVE DONE TO ENHANCE THE NIH,

2056
01:27:25,554 --> 01:27:28,056
AND THIS IS JUST A SMALL TOKEN

2057
01:27:28,056 --> 01:27:32,127
OF WHAT REALLY COUNTS IS THE

2058
01:27:32,127 --> 01:27:33,528
PEOPLE WHO ARE ONLINE, EVERYBODY

2059
01:27:33,528 --> 01:27:38,667
WHO IS HERE, AND IT REALLY IS

2060
01:27:38,667 --> 01:27:39,901
INCREDIBLE.

2061
01:27:39,901 --> 01:27:41,203
>> THANK YOU SO MUCH.

2062
01:27:41,203 --> 01:27:47,209
[APPLAUSE]

2063
01:27:47,209 --> 01:27:49,044
>> AS JENNIFER SAID,
EVERYBODY

2064
01:27:49,044 --> 01:27:51,012
HAS ALREADY SAID EVERYTHING.

2065
01:27:51,012 --> 01:27:53,615
BUT NOT ME.

2066
01:27:53,615 --> 01:27:58,887
I JUST WANT TO GIVE YOU JUST A

2067
01:27:58,887 --> 01:28:02,691
COUPLE OF VIGNETTES ABOUT THE

2068
01:28:02,691 --> 01:28:05,193
INCREDIBLE ACCOMPLISHMENT OF KEN

2069
01:28:05,193 --> 01:28:07,729
AND HIS LAB.

2070
01:28:07,729 --> 01:28:11,133
WHETHER IT WAS XERODERMA

2071
01:28:11,133 --> 01:28:13,401
PIGMENTOSUM, OR OTHER CUTANEOUS

2072
01:28:13,401 --> 01:28:16,338
DISEASES WITH DNA REPAIR

2073
01:28:16,338 --> 01:28:19,841
DEFECTS, HE HAS ALWAYS MADE HIS

2074
01:28:19,841 --> 01:28:20,876
MARK.

2075
01:28:20,876 --> 01:28:22,577
BUT NOT JUST IN THE LABORATORY.

2076
01:28:22,577 --> 01:28:25,981
AS YOU HAVE HEARD, THE HUMAN

2077
01:28:25,981 --> 01:28:28,583
DIMENSION FOR KEN HAS REALLY

2078
01:28:28,583 --> 01:28:30,986
BEEN EXTRAORDINARY, AND YOU

2079
01:28:30,986 --> 01:28:33,288
KNOW, YOU'VE HEARD ABOUT HOW

2080
01:28:33,288 --> 01:28:35,457
MANY PEOPLE'S LIVES HAVE BEEN

2081
01:28:35,457 --> 01:28:36,591
TOUCHED BY HIM.

2082
01:28:36,591 --> 01:28:39,861
ON THE ONE HAND, PATIENTS, WHERE

2083
01:28:39,861 --> 01:28:42,130
HE HAS BEEN ABLE TO IMPROVE

2084
01:28:42,130 --> 01:28:44,633
THEIR OUTLOOK, WHICH IS NOT

2085
01:28:44,633 --> 01:28:47,469
EASY, ESPECIALLY FOR A RARE

2086
01:28:47,469 --> 01:28:50,138
CONDITION SUCH AS XP.

2087
01:28:50,138 --> 01:28:54,509
BUT IN ADDITION, THE TRAINEES,

2088
01:28:54,509 --> 01:28:58,880
WHERE HIS MENTORING HAS REALLY

2089
01:28:58,880 --> 01:29:00,615
HAD AN EXTRAORDINARY IMPACT.

2090
01:29:00,615 --> 01:29:03,018
BUT I WOULD BE REMISS IF I

2091
01:29:03,018 --> 01:29:04,920
DIDN'T SAY THE MOST IMPORTANT

2092
01:29:04,920 --> 01:29:08,590
THING RIGHT NOW, WHICH IS THAT I

2093
01:29:08,590 --> 01:29:12,661
HAVE A FEELING THAT BECAUSE OF

2094
01:29:12,661 --> 01:29:14,729
DORIS, KEN IS NOT GOING TO FAIL

2095
01:29:14,729 --> 01:29:16,364
RETIREMENT.

2096
01:29:16,364 --> 01:29:21,269
HE IS GOING TO REALLY BE ABLE TO

2097
01:29:21,269 --> 01:29:25,106
ENJOY IT, LOOK BACK ON AN

2098
01:29:25,106 --> 01:29:28,143
INCREDIBLE CAREER, AND AS WAS

2099
01:29:28,143 --> 01:29:30,212
SAID, THE NEXT CHAPTER OF HIS

2100
01:29:30,212 --> 01:29:32,981
LIFE.

2101
01:29:32,981 --> 01:29:33,215
ANYWAY.

2102
01:29:33,215 --> 01:29:43,391
[APPLAUSE]

2103
01:30:01,409 --> 01:30:02,844
>> WELL, I WANT TO THANK

2104
01:30:02,844 --> 01:30:05,380
EVERYBODY FOR BEING HERE.

2105
01:30:05,380 --> 01:30:06,882
AND ALL THE HARD WORK THAT WENT

2106
01:30:06,882 --> 01:30:08,650
INTO THIS.

2107
01:30:08,650 --> 01:30:14,422
AND HAVING THE MULT MULTIMEDIA R

2108
01:30:14,422 --> 01:30:15,957
THE PEOPLE HERE AND IN EUROPE

2109
01:30:15,957 --> 01:30:18,260
AND WHO ARE STAYING UP LATE,

2110
01:30:18,260 --> 01:30:19,127
THIS IS VERY NICE.

2111
01:30:19,127 --> 01:30:23,598
I'D ALSO LIKE TO POINT OUT THAT

2112
01:30:23,598 --> 01:30:26,434
DEBBY, OUR WONDERFUL RESEARCH

2113
01:30:26,434 --> 01:30:27,936
NURSE, AS A LABOR OF LOVE,

2114
01:30:27,936 --> 01:30:31,039
COLLECTED LETTERS AND NEWS

2115
01:30:31,039 --> 01:30:33,208
ARTICLES AND OTHERS ABOUT THE

2116
01:30:33,208 --> 01:30:35,143
PATIENT THAT WE'VE SEEN OVER THE

2117
01:30:35,143 --> 01:30:36,745
DECADES, AND THERE ARE TWO

2118
01:30:36,745 --> 01:30:39,848
ALBUMS ON THE BACK ON THE TABLE

2119
01:30:39,848 --> 01:30:41,283
THERE, ENCOURAGE YOU TO TAKE A

2120
01:30:41,283 --> 01:30:44,886
LOOK AT THOSE.

2121
01:30:44,886 --> 01:30:45,520
OKAY.

2122
01:30:45,520 --> 01:30:49,024
50 YEARS OF STUDYING DNA REPAIR

2123
01:30:49,024 --> 01:30:53,828
AT NIH, WHERE DID THE TIME GO?

2124
01:30:53,828 --> 01:30:58,533
1965, WE STARTED OUT, MARRIED MY

2125
01:30:58,533 --> 01:31:00,001
HIGH SCHOOL SWEETHEART WHO

2126
01:31:00,001 --> 01:31:01,036
YOU'VE BEEN HEARING ABOUT, AND

2127
01:31:01,036 --> 01:31:03,271
WE'RE STILL MARRIED.

2128
01:31:03,271 --> 01:31:11,880
[APPLAUSE]

2129
01:31:11,880 --> 01:31:14,616
SO I WENT TO BROWN

2130
01:31:14,616 --> 01:31:15,383
UNDERGRADUATE, BROWN UNIVERSITY

2131
01:31:15,383 --> 01:31:19,321
UNDERGRADUATE AND THEN WENT TO

2132
01:31:19,321 --> 01:31:21,456
BOSTON AND THEN DORIS WAS AT

2133
01:31:21,456 --> 01:31:22,824
BOSTON UNIVERSITY, THEN WE GOT

2134
01:31:22,824 --> 01:31:25,860
MARRIED, AND THEN I STARTED THE

2135
01:31:25,860 --> 01:31:28,830
MEDICAL INTERNSHIP AND RESIDENCY

2136
01:31:28,830 --> 01:31:30,565
IN NEW YORK CITY, 1971, AND THIS

2137
01:31:30,565 --> 01:31:33,902
IS WHAT I LOOKED LIKE THEN.

2138
01:31:33,902 --> 01:31:44,446
AND THAT IS -- THAT IS OUR FIRST

2139
01:31:45,547 --> 01:31:49,551
SORNTION THSON, THAT'S MARTIN, S

2140
01:31:49,551 --> 01:31:50,719
HERE, HE IS THE SECOND SON.

2141
01:31:50,719 --> 01:31:52,988
THIS IS WHAT I LOOKED LIKE.

2142
01:31:52,988 --> 01:31:54,656
AND THE VIETNAM WAR WAS GOING ON

2143
01:31:54,656 --> 01:31:55,957
THERE.

2144
01:31:55,957 --> 01:31:56,825
I WAS DEFINITELY INTERESTED IN

2145
01:31:56,825 --> 01:31:59,127
DOING RESEARCH.

2146
01:31:59,127 --> 01:32:01,730
I APPLIED TO NIH AND WAS LUCKY

2147
01:32:01,730 --> 01:32:04,466
TO GET INTO THE PUBLIC HEALTH

2148
01:32:04,466 --> 01:32:07,402
SERVICE, SO THEY CLEANED ME UP.

2149
01:32:07,402 --> 01:32:10,038
WHEN I CAME HERE.

2150
01:32:10,038 --> 01:32:11,439
SO LET'S GIVE YOU A LITTLE

2151
01:32:11,439 --> 01:32:14,843
TIMELINE WHERE WE ARE.

2152
01:32:14,843 --> 01:32:18,213
1953, DNA STRUCTURE WAS

2153
01:32:18,213 --> 01:32:22,283
PUBLISHED, AS WE KNOW, SO

2154
01:32:22,283 --> 01:32:23,918
ROSALYN FRANKLIN PLAYED A ROLE

2155
01:32:23,918 --> 01:32:29,257
IN THIS -- NCI NOW GETS THE

2156
01:32:29,257 --> 01:32:30,025
FRANKLIN AWARD EACH YEAR.

2157
01:32:30,025 --> 01:32:33,528
SO RIGHT HERE AT NIH, MARSHAL

2158
01:32:33,528 --> 01:32:34,729
NUREMBERG WAS CRACKING THE

2159
01:32:34,729 --> 01:32:39,868
GENETIC CODE, 1951.

2160
01:32:39,868 --> 01:32:41,803
1959, JAMES KLIBER REPORTED ON

2161
01:32:41,803 --> 01:32:43,371
THE DNA REPAIR DEFECT IN

2162
01:32:43,371 --> 01:32:45,974
PATIENTS WITH THIS UNUSUAL

2163
01:32:45,974 --> 01:32:50,578
DISEASE, XP.

2164
01:32:50,578 --> 01:32:54,949
HE WAS AT THE UNIVERSITY OF

2165
01:32:54,949 --> 01:32:56,151
CALIFORNIA, SAN FRANCISCO.

2166
01:32:56,151 --> 01:32:58,086
1971 I JOINED THE PUBLIC HEALTH

2167
01:32:58,086 --> 01:33:00,088
SERVICE I JOINED AT THE

2168
01:33:00,088 --> 01:33:02,257
DERMATOLOGY BRANCH AT NCI.

2169
01:33:02,257 --> 01:33:07,062
AND THEN 1977, WHEN THE --

2170
01:33:07,062 --> 01:33:10,565
STARTED SEQUENCING.

2171
01:33:10,565 --> 01:33:16,805
SO THERE I WAS, OFFICER IN THE

2172
01:33:16,805 --> 01:33:17,572
U.S. PUBLIC HEALTH SERVICE,

2173
01:33:17,572 --> 01:33:19,607
HERE'S MY COMMISSION FROM THE

2174
01:33:19,607 --> 01:33:19,974
PRESIDENT.

2175
01:33:19,974 --> 01:33:21,609
I WAS THERE FOR 30 YEARS UNTIL

2176
01:33:21,609 --> 01:33:23,378
THEY KICKED ME OUT.

2177
01:33:23,378 --> 01:33:26,247
BUT DURING THIS TIME, I

2178
01:33:26,247 --> 01:33:30,051
VOLUNTEERED TO SERVE AS AN

2179
01:33:30,051 --> 01:33:33,121
INTERVIEWER FOR -- UNIFORMED

2180
01:33:33,121 --> 01:33:34,255
SERVICES.

2181
01:33:34,255 --> 01:33:40,128
CLOSE TO 200 OF THEM.

2182
01:33:40,128 --> 01:33:44,732
PROFESSOR OF DERMATOLOGY THERE.

2183
01:33:44,732 --> 01:33:46,701
SO WHAT DID NIH LOOK LIKE HERE,

2184
01:33:46,701 --> 01:33:48,770
THE CANCER INSTITUTE?

2185
01:33:48,770 --> 01:33:50,105
HERE'S THE CLINICAL STAFF

2186
01:33:50,105 --> 01:33:50,538
PHOTOGRAPH.

2187
01:33:50,538 --> 01:33:51,639
YOU CAN FIND ME WAY UP IN THE

2188
01:33:51,639 --> 01:33:53,908
CORNER.

2189
01:33:53,908 --> 01:33:56,945
ONE OF THE UNUSUAL THINGS ABOUT

2190
01:33:56,945 --> 01:33:59,247
THIS, ON THE FIRST ROW HAD

2191
01:33:59,247 --> 01:34:02,650
SENIOR STAFF, AND -- WHAT WAS

2192
01:34:02,650 --> 01:34:06,020
HER NAME?

2193
01:34:06,020 --> 01:34:09,891
BRIDBRIDGET -- SHE'S THE ONLY WN

2194
01:34:09,891 --> 01:34:11,960
IN THIS WHOLE PICTURE.

2195
01:34:11,960 --> 01:34:12,827
SHE'S SENIOR STAFF AND THERE

2196
01:34:12,827 --> 01:34:15,063
WERE NO WOMEN IN CLINICAL

2197
01:34:15,063 --> 01:34:15,363
ASSOCIATES.

2198
01:34:15,363 --> 01:34:17,098
SO YOU CAN SEE HOW THINGS HAVE

2199
01:34:17,098 --> 01:34:18,833
CHANGED.

2200
01:34:18,833 --> 01:34:20,668
SO I WAS WORKING IN THE

2201
01:34:20,668 --> 01:34:21,669
DERMATOLOGY BRANCH, I WAS

2202
01:34:21,669 --> 01:34:23,204
ASSIGNED TO WORK IN THE

2203
01:34:23,204 --> 01:34:24,839
DERMATOLOGY BRANCH AND I'VE

2204
01:34:24,839 --> 01:34:28,776
WORKED WITH DR. JAY ROBBINS,

2205
01:34:28,776 --> 01:34:31,513
1971, JAMES KLIBER HAD COME TO

2206
01:34:31,513 --> 01:34:33,348
NIH AND A LITTLE BEFORE THAT TO

2207
01:34:33,348 --> 01:34:35,250
TELL US ABOUT THE DNA REPAIR

2208
01:34:35,250 --> 01:34:36,317
DEFECT, AND SO I GOT INTERESTED

2209
01:34:36,317 --> 01:34:43,658
IN WORKING WITH XERODERMA.

2210
01:34:43,658 --> 01:34:45,260
SO WE WERE BRINGING PATIENTS IN

2211
01:34:45,260 --> 01:34:48,163
AND A FEW YEARS LATER, WE

2212
01:34:48,163 --> 01:34:52,100
PUBLISHED THIS DETAILED CLINICAL

2213
01:34:52,100 --> 01:34:56,671
LABORATORY DESCRIPTION OF 15 XP

2214
01:34:56,671 --> 01:34:58,206
PATIENTS, THEY HAD FOUR CLINICAL

2215
01:34:58,206 --> 01:35:00,508
PHENOTYPES AND THIS IS

2216
01:35:00,508 --> 01:35:02,911
CONSIDERED A CITATION CLASSIC.

2217
01:35:02,911 --> 01:35:06,514
THIS WAS XP1 -- WHO HAD

2218
01:35:06,514 --> 01:35:08,049
DEFECTIVE DNA REPAIR.

2219
01:35:08,049 --> 01:35:10,018
HE HAD NORMAL DNA REPAIR.

2220
01:35:10,018 --> 01:35:11,219
THAT WAS UNUSUAL.

2221
01:35:11,219 --> 01:35:16,257
AND THAT HE WAS -- SO WHY DO WE

2222
01:35:16,257 --> 01:35:17,792
STUDY RARE HUMAN GENETIC

2223
01:35:17,792 --> 01:35:18,326
DISEASES?

2224
01:35:18,326 --> 01:35:20,628
WE CARE FOR AFFECTED PATIENTS,

2225
01:35:20,628 --> 01:35:22,530
DISCOVER MECHANISMS OF DISEASE,

2226
01:35:22,530 --> 01:35:25,133
AND DEVELOP NEW THERAPEUTIC

2227
01:35:25,133 --> 01:35:27,902
PARADIGMS USING SMALL NUMBERS OF

2228
01:35:27,902 --> 01:35:30,038
PATIENTS AT HIGH RISK.

2229
01:35:30,038 --> 01:35:34,209
SO I WENT TO -- I WAS THROW

2230
01:35:34,209 --> 01:35:36,844
YEARS IN THE DERMATOLOGY BRANCH

2231
01:35:36,844 --> 01:35:38,446
INITIALLY AND THEN I WENT TO

2232
01:35:38,446 --> 01:35:40,748
MIAMI AND DID DERMATOLOGY

2233
01:35:40,748 --> 01:35:41,749
TRAINING AND I CAME BACK AND

2234
01:35:41,749 --> 01:35:44,052
JOINED THE LABORATORY OF

2235
01:35:44,052 --> 01:35:46,988
MOLECULAR CARCINOGENESIS, 1976

2236
01:35:46,988 --> 01:35:48,823
TO 1999.

2237
01:35:48,823 --> 01:35:53,795
THIS IS HARRY GELBOIN, BRANCH

2238
01:35:53,795 --> 01:35:57,932
CHIEF, VERY INTERESTING, HE

2239
01:35:57,932 --> 01:36:03,071
CLIMBED MOUNT KILL MOUNT KILIMAW

2240
01:36:03,071 --> 01:36:03,605
TIMES.

2241
01:36:03,605 --> 01:36:05,139
THEN PARACHUTED FROM THERE.

2242
01:36:05,139 --> 01:36:08,543
AS YOU HEARD FROM DR. BOHR, WE

2243
01:36:08,543 --> 01:36:10,411
HAD THE DNA REPAIR INTEREST

2244
01:36:10,411 --> 01:36:10,812
GROUP.

2245
01:36:10,812 --> 01:36:14,983
WHEN WE STARTED, WE WERE A

2246
01:36:14,983 --> 01:36:18,820
LITTLE VAGUE, 1985.

2247
01:36:18,820 --> 01:36:20,588
AT THIS POINT, CHARLENE HAS

2248
01:36:20,588 --> 01:36:22,757
DOCUMENTED THEM FOR ME, THANK

2249
01:36:22,757 --> 01:36:23,758
YOU, CHARLENE.

2250
01:36:23,758 --> 01:36:26,261
WE HAVE AN EMAIL LIST OF MORE

2251
01:36:26,261 --> 01:36:30,265
THAN 1200 SUBSCRIBERS, AND IN

2252
01:36:30,265 --> 01:36:32,267
2023, BOTH VIL AND I STEPPED

2253
01:36:32,267 --> 01:36:36,671
DOWN AND KAREN AND CHUNZHANG

2254
01:36:36,671 --> 01:36:38,172
TOOK OVER.

2255
01:36:38,172 --> 01:36:40,908
ANOTHER PAPER WE DID WORKING

2256
01:36:40,908 --> 01:36:42,877
WITH JOHN, JOHN UNFORTUNATELY

2257
01:36:42,877 --> 01:36:47,815
PASSED AWAY A YEAR AGO.

2258
01:36:47,815 --> 01:36:49,450
DR. -- WAS TALKING ABOUT

2259
01:36:49,450 --> 01:36:49,884
RETINOIDS.

2260
01:36:49,884 --> 01:36:53,755
THIS IS THE STUDY WHERE WE SHO

2261
01:36:53,755 --> 01:36:56,024
SHOWED -- WERE GOOD AT

2262
01:36:56,024 --> 01:36:57,091
PREVENTING CANCER IN XP

2263
01:36:57,091 --> 01:36:57,592
PATIENTS.

2264
01:36:57,592 --> 01:37:02,563
SO HERE'S A PATIENT, 43 TE TUMO,

2265
01:37:02,563 --> 01:37:06,067
DURING THE TREATMENT WITH

2266
01:37:06,067 --> 01:37:08,703
ACCUTANE - -- SO THIS WAS ACTUAY

2267
01:37:08,703 --> 01:37:11,739
THE FIRST DEMONSTRATION OF

2268
01:37:11,739 --> 01:37:12,740
CANCER -- PREVENTION USING

2269
01:37:12,740 --> 01:37:14,375
MEDICINES TO PREVENT CANCER IN

2270
01:37:14,375 --> 01:37:19,614
HUMANS.

2271
01:37:19,614 --> 01:37:25,320
 -- PATIENTS WHO HAD MANY TUM 

2272
01:37:25,320 --> 01:37:26,220
TUMORS -- THIS WAS NEW ENGLAND

2273
01:37:26,220 --> 01:37:26,454
JOURNAL.

2274
01:37:26,454 --> 01:37:31,559
WE WORKED CLOSELY WITH A

2275
01:37:31,559 --> 01:37:35,163
STATISTICIAN, E EPIDEMIOLOGIST.

2276
01:37:35,163 --> 01:37:39,434
SO HERE'S A MEETING IN 1995 IN

2277
01:37:39,434 --> 01:37:42,704
MEXICO WITH DR. KLIBER, AND TWO

2278
01:37:42,704 --> 01:37:53,247
OF THE POSTDOCS IN THE LAB.

2279
01:38:00,388 --> 01:38:04,058
AND THERE'S MICHELE.

2280
01:38:04,058 --> 01:38:06,794
SHE WAS AT THAT MEETING ALSO.

2281
01:38:06,794 --> 01:38:15,103
WE'LL LET HER -- AND DR. BOHR.

2282
01:38:15,103 --> 01:38:18,940
SO WE STARTED THESE -- NCI SAID

2283
01:38:18,940 --> 01:38:21,876
HERE WE HAVE SOME MONEY, LET'S

2284
01:38:21,876 --> 01:38:23,311
DO A CONFERENCE, SO WE SAID

2285
01:38:23,311 --> 01:38:24,078
OKAY.

2286
01:38:24,078 --> 01:38:25,880
SO WE HAD THIS NOVEL CONCEPT AT

2287
01:38:25,880 --> 01:38:27,882
THE TIME, AT LEAST, OF BRINGING

2288
01:38:27,882 --> 01:38:30,084
TOGETHER BASICALLY RESEARCHERS,

2289
01:38:30,084 --> 01:38:31,386
CLINICIANS AND PAPERS.

2290
01:38:31,386 --> 01:38:33,888
AND SO IT WASN'T TOO HARD TO GET

2291
01:38:33,888 --> 01:38:37,759
THESE IK RESEARCHERS -- THE

2292
01:38:37,759 --> 01:38:39,694
CLINICIANS WERE A LITTLE HARDER

2293
01:38:39,694 --> 01:38:41,996
BUT THE PATIENTS -- BECAUSE I

2294
01:38:41,996 --> 01:38:50,104
WENT TO -- [INAUDIBLE] BUT

2295
01:38:50,104 --> 01:38:51,639
HERE'S THE MEETING, THE FIRST

2296
01:38:51,639 --> 01:38:55,143
ONE IN 2004, THE NATIONAL

2297
01:38:55,143 --> 01:38:57,011
CONFERENCE IN VIRGINIA AND THEN

2298
01:38:57,011 --> 01:39:00,281
THEY HAD 2006 TO 2010 -- AND A

2299
01:39:00,281 --> 01:39:02,350
LOT OF THESE BASIC RESEARCHERS

2300
01:39:02,350 --> 01:39:03,751
HAVE NEVER SEEN PATIENTS, SOME

2301
01:39:03,751 --> 01:39:07,288
OF THEM REALLY GOT INSPIRED.

2302
01:39:07,288 --> 01:39:10,558
AND DEVELOPED CAREERS WITH THEM.

2303
01:39:10,558 --> 01:39:17,465
AND THEN -- AND WE BRING NOT

2304
01:39:17,465 --> 01:39:20,334
ONLY -- BUT WE BRING STUDENTS

2305
01:39:20,334 --> 01:39:22,270
FROM LOCAL HIGH SCHOOLS.

2306
01:39:22,270 --> 01:39:23,404
THE FIRST ONE WAS HERE IN

2307
01:39:23,404 --> 01:39:27,108
WASHINGTON.

2308
01:39:27,108 --> 01:39:30,645
SO SHE BROUGHT HER CLASS.

2309
01:39:30,645 --> 01:39:33,047
THESE HIGH SCHOOL KIDS WOULD

2310
01:39:33,047 --> 01:39:36,117
SPEND A DAY TALKING TO

2311
01:39:36,117 --> 01:39:36,751
DERMATOLOGISTS.

2312
01:39:36,751 --> 01:39:38,886
MANY OF THE MEMBERS OF THE --

2313
01:39:38,886 --> 01:39:42,990
WERE VERY INTERESTED -- LUNCHEON

2314
01:39:42,990 --> 01:39:44,525
FOR THEM AND THEY WOULD TALK

2315
01:39:44,525 --> 01:39:46,828
ABOUT THEIR CAREERS AND WHY THEY

2316
01:39:46,828 --> 01:39:53,301
WENT INTO DERMATOLOGY, -- IT

2317
01:39:53,301 --> 01:39:56,804
DIDN'T WORK.

2318
01:39:56,804 --> 01:39:58,506
SO THAT WENT ON FOR A LONG

2319
01:39:58,506 --> 01:40:02,810
PERIOD OF TIME.

2320
01:40:02,810 --> 01:40:05,446
AND BE EVENT LIP I RECEIVED AN

2321
01:40:05,446 --> 01:40:06,080
AWARD FOR THIS.

2322
01:40:06,080 --> 01:40:08,149
THE PROGRAM -- DERMATOLOGY

2323
01:40:08,149 --> 01:40:15,389
EDUCATION FOR STUDENTS -- AND

2324
01:40:15,389 --> 01:40:18,259
THEN I STARTED WORKING WITH

2325
01:40:18,259 --> 01:40:21,496
PEGGY TUCKER, WHO YOU HEARD, AND

2326
01:40:21,496 --> 01:40:23,598
ALSO ELISA GOLDSTEIN, AND THEY

2327
01:40:23,598 --> 01:40:26,000
HAD A FELLOW WHO WAS INTERESTED

2328
01:40:26,000 --> 01:40:27,902
IN DERMATOLOGY.

2329
01:40:27,902 --> 01:40:30,471
AND WE WENT THROUGH ALL OF THIS

2330
01:40:30,471 --> 01:40:32,473
40 YEARS OF DATA THAT WE HAD

2331
01:40:32,473 --> 01:40:34,442
ALREADY ACCUMULATED ON OUR XP

2332
01:40:34,442 --> 01:40:37,812
PATIENTS TO SEE HOW MANY SKIN

2333
01:40:37,812 --> 01:40:39,780
CANCERS AND OTHER -- THIS IS THE

2334
01:40:39,780 --> 01:40:42,216
FIRST TIME WE REALLY WERE ABLE

2335
01:40:42,216 --> 01:40:43,951
TO GET GOOD CONCENTRATED

2336
01:40:43,951 --> 01:40:46,821
NUMBERS, AND THE XP PATIENTS

2337
01:40:46,821 --> 01:40:49,557
THAT HAD -- IN AGE OF ONSET OF

2338
01:40:49,557 --> 01:40:53,594
SKIN CANCER, NON-MELANOMA SKIN

2339
01:40:53,594 --> 01:40:58,199
CANCER, AND LISA GOLDSTEIN --

2340
01:40:58,199 --> 01:41:01,168
THIS IS ABOUT A 10,000 FOLD

2341
01:41:01,168 --> 01:41:05,873
ENTRY IN SKIN CANCER AND AGE OF

2342
01:41:05,873 --> 01:41:08,509
ONSET IN XP PATIENTS.

2343
01:41:08,509 --> 01:41:10,878
IT WAS AT A DIFFERENT MEETING,

2344
01:41:10,878 --> 01:41:14,315
22 VERSUS -- IN THE DISTANCE

2345
01:41:14,315 --> 01:41:16,517
BETWEEN THE GENERAL POPULATION.

2346
01:41:16,517 --> 01:41:18,386
SO THIS TELLS US RIGHT AWAY THAT

2347
01:41:18,386 --> 01:41:20,988
MELANOMA INDUCTION MECHANISM IS

2348
01:41:20,988 --> 01:41:23,858
DIFFERENT FROM NON-MELANOMA SKIN

2349
01:41:23,858 --> 01:41:24,692
CANCER.

2350
01:41:24,692 --> 01:41:33,067
JUST BY STUDYING -- CANCER AN

2351
01:41:33,067 --> 01:41:34,802
AND -- THIS IS THE AMERICAN

2352
01:41:34,802 --> 01:41:37,038
ACADEMY OF DERMATOLOGY.

2353
01:41:37,038 --> 01:41:40,541
FOR MANY YEARS, JOHN AND I WOULD

2354
01:41:40,541 --> 01:41:45,246
HAVE A -- ON SATURDAY MORNING

2355
01:41:45,246 --> 01:41:48,449
WHERE WE -- DERMATOLOGISTS FROM

2356
01:41:48,449 --> 01:41:50,518
ALL OVER THE WORLD WHO ARE AT

2357
01:41:50,518 --> 01:41:57,758
THE ACADEMY MEETING, AND --

2358
01:41:57,758 --> 01:42:00,595
WOULD COME AND TALK, RESIDENTS

2359
01:42:00,595 --> 01:42:03,230
WITH XP, WHATEVER PROBLEMS, AND

2360
01:42:03,230 --> 01:42:05,967
THERE IS MICHELE MIOTA.

2361
01:42:05,967 --> 01:42:11,205
I SEE YOU OFTEN ATTENDED THAT.

2362
01:42:11,205 --> 01:42:17,011
SO THIS IS CALLED THE XP -- AT

2363
01:42:17,011 --> 01:42:17,678
THE AMERICAN ACADEMY OF

2364
01:42:17,678 --> 01:42:18,412
DERMATOLOGY.

2365
01:42:18,412 --> 01:42:22,683
WE HAVE A TRAY DIGS, IT WAS THE

2366
01:42:22,683 --> 01:42:24,785
SUMMER BEFORE COVID, WE HAD A

2367
01:42:24,785 --> 01:42:25,886
POTLUCK DINNER.

2368
01:42:25,886 --> 01:42:27,421
FOR MANY YEARS.

2369
01:42:27,421 --> 01:42:31,125
THIS WAS A FAMILY EVENT AND WE'D

2370
01:42:31,125 --> 01:42:34,629
ENCOURAGE PEOPLE -- HERE WE HAVE

2371
01:42:34,629 --> 01:42:41,302
SUMMER STUDENTS, WE WANT TO --

2372
01:42:41,302 --> 01:42:48,576
AND -- HERE IS SIKANDER, HERE IS

2373
01:42:48,576 --> 01:42:49,010
DEBBY.

2374
01:42:49,010 --> 01:42:50,244
HE WAS TALKING ABOUT BRINGING

2375
01:42:50,244 --> 01:42:54,782
HIS CHILDREN TO THIS MEETING.

2376
01:42:54,782 --> 01:42:56,951
WE HAD A SITE VISIT, AND THE

2377
01:42:56,951 --> 01:42:59,620
PEOPLE A FEW YEARS AGO FOR LCBG

2378
01:42:59,620 --> 01:43:04,659
AND THE PEOPLE IN THE LAB -- PUT

2379
01:43:04,659 --> 01:43:06,627
TOGETHER A POSTER -- WE ARE A

2380
01:43:06,627 --> 01:43:10,464
FAMILY, I THINK IS APPEARING.

2381
01:43:10,464 --> 01:43:15,069
AND THE LONG-TIME MEMBERS OF THE

2382
01:43:15,069 --> 01:43:18,139
TEAM, -- UNFORTUNATELY PASSED

2383
01:43:18,139 --> 01:43:22,943
AWAY A YEAR AGO, BUT DEBBY --

2384
01:43:22,943 --> 01:43:28,215
SUPERB RENURSE AND SIKANDAR

2385
01:43:28,215 --> 01:43:29,150
KHAN.

2386
01:43:29,150 --> 01:43:33,320
AND THE LCBG, SINCE 2017, AND

2387
01:43:33,320 --> 01:43:38,959
THANK YOU VERY MUCH, WONDERFUL.

2388
01:43:38,959 --> 01:43:40,961
[APPLAUSE]

2389
01:43:40,961 --> 01:43:47,301
BUT THERE'S MORE.

2390
01:43:47,301 --> 01:43:49,904
NOW WE GO ON TO RETIREMENT.

2391
01:43:49,904 --> 01:43:53,074
SO THIS YEAR, WE'VE GOT FOUR

2392
01:43:53,074 --> 01:43:54,975
KIDS ALL OVER THE COUNTRY, SO

2393
01:43:54,975 --> 01:43:57,812
UNTIL JANUARY WE WENT TO TUCSON,

2394
01:43:57,812 --> 01:43:59,346
ARIZONA, WHERE IT'S NICE AND

2395
01:43:59,346 --> 01:43:59,547
WARM.

2396
01:43:59,547 --> 01:44:04,819
IT'S COLD HERE, IT WARM THERE.

2397
01:44:04,819 --> 01:44:06,687
IN FEBRUARY WE WERE JUST IN

2398
01:44:06,687 --> 01:44:08,923
CALIFORNIA, SAN FRANCISCO, BUT

2399
01:44:08,923 --> 01:44:10,091
MARTIN HERE, HE'S THE ONE THAT

2400
01:44:10,091 --> 01:44:11,625
WAS IN THE ORIGINAL PICTURE THAT

2401
01:44:11,625 --> 01:44:15,229
WE SHOWED, 1971 WITH MARTIN,

2402
01:44:15,229 --> 01:44:17,531
THIS IS HIS FAMILY AND OUR

2403
01:44:17,531 --> 01:44:19,734
DAUGHTER IS IN SAN FRANCISCO.

2404
01:44:19,734 --> 01:44:24,338
REBECCA IS HERE FROM ANN ARBOR,

2405
01:44:24,338 --> 01:44:29,376
TO GO VISIT THEM, AND THEN DAVID

2406
01:44:29,376 --> 01:44:31,278
IS LIVING IN VERMONT, THIS IS

2407
01:44:31,278 --> 01:44:32,646
HIS FARM, AND HERE'S WHEN THE

2408
01:44:32,646 --> 01:44:35,516
WHOLE FAMILY GOT TOGETHER THERE.

2409
01:44:35,516 --> 01:44:41,622
AND NOW, TO THE BIG REVEAL.

2410
01:44:41,622 --> 01:44:44,258
THIS IS THE SHIRT.

2411
01:44:44,258 --> 01:44:48,095
MY DAUGHTER SARAH MADE THIS.

2412
01:44:48,095 --> 01:44:58,272
[APPLAUSE]

2413
01:45:01,208 --> 01:45:02,676
SHE'S AN ARTISTIC LAWYER, AND

2414
01:45:02,676 --> 01:45:04,945
SHE ASKED WHAT REPLICATING DNA

2415
01:45:04,945 --> 01:45:08,449
LOOKS LIKE, AND HERE WE GO.

2416
01:45:08,449 --> 01:45:10,251
THESE ARE DIFFERENT PARTS OF THE

2417
01:45:10,251 --> 01:45:13,921
WORLD WE WENT TO, JUST

2418
01:45:13,921 --> 01:45:15,589
ORGANIZATIONS THAT YOU'VE BEEN

2419
01:45:15,589 --> 01:45:18,092
HEARING ABOUT, FAMILY MEMBERS,

2420
01:45:18,092 --> 01:45:23,030
NIH, 50 YEARS OF NIH.

2421
01:45:23,030 --> 01:45:24,365
THERE IT IS.

2422
01:45:24,365 --> 01:45:34,542
[APPLAUSE]

2423
01:45:43,784 --> 01:45:45,686
>> THANK YOU, KEN, THAT
WAS

2424
01:45:45,686 --> 01:45:46,453
AMAZING.

2425
01:45:46,453 --> 01:45:47,354
BEAUTIFUL LOOKING SHIRT.

2426
01:45:47,354 --> 01:45:51,091
>> DR. KRAEMER, DO YOU
HAVE --

2427
01:45:51,091 --> 01:45:52,693
>> WE'RE JUST GOING TO DO

2428
01:45:52,693 --> 01:45:53,694
EVERYTHING HERE.

2429
01:45:53,694 --> 01:45:54,028
OH, SORRY.

2430
01:45:54,028 --> 01:45:55,229
WHAT WAS THAT?

2431
01:45:55,229 --> 01:45:57,965
>> DO YOU MIND IF I SHARE
THE

2432
01:45:57,965 --> 01:45:58,632
SLIDES?

2433
01:45:58,632 --> 01:46:00,701
THEY'RE VERY BRIEF.

2434
01:46:00,701 --> 01:46:05,639
OKAY.

2435
01:46:05,639 --> 01:46:06,507
I'LL TRY THIS AGAIN.

2436
01:46:06,507 --> 01:46:11,912
HERE WE GO.

2437
01:46:11,912 --> 01:46:12,646
>> OKAY.

2438
01:46:12,646 --> 01:46:17,484
GO FOR IT, JENNIFER.

2439
01:46:17,484 --> 01:46:18,118
>> OKAY.

2440
01:46:18,118 --> 01:46:20,221
CAN YOU SEE MY SCREEN?

2441
01:46:20,221 --> 01:46:21,755
>> YES.

2442
01:46:21,755 --> 01:46:25,259
>> OKAY.

2443
01:46:25,259 --> 01:46:28,429
SO THESE ARE JUST SOME PHOTOS --

2444
01:46:28,429 --> 01:46:29,129
WAIT.

2445
01:46:29,129 --> 01:46:29,964
OKAY.

2446
01:46:29,964 --> 01:46:32,066
PHOTOS OF THE LAB.

2447
01:46:32,066 --> 01:46:33,801
SO WHEN MY PARENTS CAME TO

2448
01:46:33,801 --> 01:46:37,204
VISIT, I THINK THIS WAS WHEN I

2449
01:46:37,204 --> 01:46:38,739
PRESENTED FOR THE DERMATOLOGY

2450
01:46:38,739 --> 01:46:39,974
BRANCH.

2451
01:46:39,974 --> 01:46:42,810
AND THEN THIS WAS JUST A LAB

2452
01:46:42,810 --> 01:46:44,745
PHOTO AS WELL.

2453
01:46:44,745 --> 01:46:46,513
AND THEN I WON'T READ THE

2454
01:46:46,513 --> 01:46:49,683
MESSAGE ON THE LEFT, BUT AS MANY

2455
01:46:49,683 --> 01:46:53,654
OF YOU SAW IN DR. KRAEMER'S

2456
01:46:53,654 --> 01:46:56,490
SLIDE SHOW, SOME OF THE

2457
01:46:56,490 --> 01:46:58,792
TAKEAWAYS OVER THE YEARS.

2458
01:46:58,792 --> 01:46:59,560
HIGHLIGHT IMPORTANT SUMMARY

2459
01:46:59,560 --> 01:47:02,830
POINTS IN YELLOW.

2460
01:47:02,830 --> 01:47:03,297
[LAUGHTER]

2461
01:47:03,297 --> 01:47:06,467
ON YOUR PRESENTATIONS.

2462
01:47:06,467 --> 01:47:07,768
THE NEXT POINT I'LL MAKE IS WHEN

2463
01:47:07,768 --> 01:47:10,070
YOU ARE IN DR. KRAEMER'S LAB,

2464
01:47:10,070 --> 01:47:12,039
YOU ARE FAMILY.

2465
01:47:12,039 --> 01:47:14,808
AND THEN AS MANY PEOPLE NOTED,

2466
01:47:14,808 --> 01:47:17,077
DORIS IS DR. KRAEMER'S RIGHT

2467
01:47:17,077 --> 01:47:19,280
HAND WOMAN.

2468
01:47:19,280 --> 01:47:21,482
AND SHE WILL BE THERE TO SUPPORT

2469
01:47:21,482 --> 01:47:24,885
AT ALL OF THE CONFERENCES.

2470
01:47:24,885 --> 01:47:27,488
AND THEN WHAT EVERYBODY

2471
01:47:27,488 --> 01:47:29,690
HIGHLIGHTS IS DR. KRAEMER IS A

2472
01:47:29,690 --> 01:47:30,491
PHENOMENAL SCIENTIST AND HE AND

2473
01:47:30,491 --> 01:47:32,660
THE TEAM HAVE MADE A LASTING

2474
01:47:32,660 --> 01:47:34,628
IMPACT ON SCIENCE AND THE LIVES

2475
01:47:34,628 --> 01:47:36,830
OF PATIENTS WITH XP, TTD AND

2476
01:47:36,830 --> 01:47:38,265
OTHER DNA REPAIR RELATED

2477
01:47:38,265 --> 01:47:41,001
DISEASES.

2478
01:47:41,001 --> 01:47:42,303
AND LAST ONE.

2479
01:47:42,303 --> 01:47:44,305
DR. KRAEMER HAS TRIED TO RETIRE

2480
01:47:44,305 --> 01:47:46,273
ONCE, SO DON'T BE SURPRISED IF

2481
01:47:46,273 --> 01:47:49,777
HE COMES BACK.

2482
01:47:49,777 --> 01:47:58,752
[APPLAUSE]

2483
01:47:58,752 --> 01:48:00,721
THESE ARE A FEW VERY SHORT

2484
01:48:00,721 --> 01:48:02,156
VIDEOS, SO IF YOU CAN HEAR THEM,

2485
01:48:02,156 --> 01:48:04,124
THEN LET'S SEE.

2486
01:48:04,124 --> 01:48:05,626
>> HELLO, DR. KRAEMER.

2487
01:48:05,626 --> 01:48:06,527
THIS IS PORSCHE LOVE.

2488
01:48:06,527 --> 01:48:08,495
I WANT TO CONGRATULATE YOU ON

2489
01:48:08,495 --> 01:48:10,364
YOUR RETIREMENT AND THANK YOU

2490
01:48:10,364 --> 01:48:12,099
FOR EVERYTHING YOU'VE DONE FOR

2491
01:48:12,099 --> 01:48:14,435
HIGH SCHOOL, MEDICAL STUDENTS,

2492
01:48:14,435 --> 01:48:16,070
AND RESIDENTS WHO WERE

2493
01:48:16,070 --> 01:48:18,472
INTERESTED IN MEDICAL SCHOOL AND

2494
01:48:18,472 --> 01:48:19,173
DERMATOLOGY.

2495
01:48:19,173 --> 01:48:20,474
WE CERTAINLY APPRECIATE

2496
01:48:20,474 --> 01:48:21,442
EVERYTHING YOU'VE DONE AND I

2497
01:48:21,442 --> 01:48:25,079
HOPE YOU ENJOY YOUR RETIREMENT.

2498
01:48:25,079 --> 01:48:26,480
>> HI, DR. KRAEMER.

2499
01:48:26,480 --> 01:48:28,048
THIS IS SAMUEL.

2500
01:48:28,048 --> 01:48:31,318
I REALLY FEEL BLESSED, HONORED

2501
01:48:31,318 --> 01:48:33,153
AND OPPORTUNED TO HAVE MET

2502
01:48:33,153 --> 01:48:34,488
SOMEONE LIKE YOU WHO WAS MY

2503
01:48:34,488 --> 01:48:35,923
MENTOR.

2504
01:48:35,923 --> 01:48:37,992
THANK YOU FOR YOUR SUPPORT, YOUR

2505
01:48:37,992 --> 01:48:40,294
ENCOURAGEMENT AND FOR YOUR

2506
01:48:40,294 --> 01:48:43,263
GUIDANCE AS I MADE MY TRANSITION

2507
01:48:43,263 --> 01:48:44,164
FROM NIH UNTIL NOW.

2508
01:48:44,164 --> 01:48:45,799
I HOPE THAT YOU HAVE A WONDERFUL

2509
01:48:45,799 --> 01:48:46,133
RETIREMENT.

2510
01:48:46,133 --> 01:48:48,535
THANK YOU AND WE'LL KEEP IN

2511
01:48:48,535 --> 01:48:49,003
TOUCH.

2512
01:48:49,003 --> 01:48:50,204
BYE.

2513
01:48:50,204 --> 01:48:52,072
>> HEY, DR. KRAEMER.

2514
01:48:52,072 --> 01:48:53,374
CONGRATULATIONS ON AN AMAZING

2515
01:48:53,374 --> 01:48:53,707
CAREER.

2516
01:48:53,707 --> 01:48:55,843
YOU'VE HAD A GREAT IMPACT NOT

2517
01:48:55,843 --> 01:48:58,245
ONLY ON DERMATOLOGY BUT ALSO THE

2518
01:48:58,245 --> 01:48:59,847
PEOPLE YOU WORK WITH, PEOPLE YOU

2519
01:48:59,847 --> 01:49:00,314
MENTORED.

2520
01:49:00,314 --> 01:49:01,949
WISH YOU ALL THE BEST IN

2521
01:49:01,949 --> 01:49:08,856
RETIREMENT.

2522
01:49:08,856 --> 01:49:10,357
>> TWO MORE.

2523
01:49:10,357 --> 01:49:11,925
>> DR. KRAEMER,
CONGRATULATIONS

2524
01:49:11,925 --> 01:49:12,526
ON YOUR RETIREMENT.

2525
01:49:12,526 --> 01:49:14,561
THANK YOU FOR TAKING A CHANCE ON

2526
01:49:14,561 --> 01:49:16,964
US, THANK YOU FOR ALLOWING THISO

2527
01:49:16,964 --> 01:49:18,799
BE BETTER VERSIONS OFF YOURSELF,

2528
01:49:18,799 --> 01:49:20,601
FOR OPENING UP OUR WORLD.

2529
01:49:20,601 --> 01:49:22,269
I HOPE YOUR RETIREMENT IS AS

2530
01:49:22,269 --> 01:49:23,370
BEAUTIFUL AS YOUR CAREER WAS AND

2531
01:49:23,370 --> 01:49:25,039
WE WISH YOU THE BEST.

2532
01:49:25,039 --> 01:49:27,975
>> HI, EVERYONE.

2533
01:49:27,975 --> 01:49:29,443
FIRST OF ALL DR. KRAEMER,

2534
01:49:29,443 --> 01:49:30,511
CONGRATULATIONS ON YOUR

2535
01:49:30,511 --> 01:49:32,813
RETIREMENT AND ON AN INCREDIBLE

2536
01:49:32,813 --> 01:49:33,414
CAREER.

2537
01:49:33,414 --> 01:49:36,150
AND I ALSO WANTED TO SAY THANK

2538
01:49:36,150 --> 01:49:37,551
YOU SO MUCH FOR ALL OF THE

2539
01:49:37,551 --> 01:49:39,520
MENTORSHIP AND ALL OF THE

2540
01:49:39,520 --> 01:49:40,287
OPPORTUNITIES YOU'VE GIVEN ME

2541
01:49:40,287 --> 01:49:42,156
WHILE I WAS A STUDENT IN YOUR

2542
01:49:42,156 --> 01:49:43,690
LAB AND AFTERWARDS.

2543
01:49:43,690 --> 01:49:46,260
I MET DR. KRAEMER WHEN I WAS A

2544
01:49:46,260 --> 01:49:48,529
FIRST YEAR MEDICAL STUDENT, AND

2545
01:49:48,529 --> 01:49:50,197
DID MY INTERNSHIP IN THE DNA

2546
01:49:50,197 --> 01:49:52,900
REPAIR LAB AND HONESTLY, THAT

2547
01:49:52,900 --> 01:49:54,802
WAS PROBABLY THE BIGGEST REASON

2548
01:49:54,802 --> 01:49:56,904
I AM IN DERMATOLOGY TODAY, AND I

2549
01:49:56,904 --> 01:49:58,539
HAVE MY DREAM JOB, I'M THE

2550
01:49:58,539 --> 01:49:59,640
DERMATOLOGY RESIDENT AT HENRY

2551
01:49:59,640 --> 01:50:02,276
FORD IN DETROIT, MICHIGAN.

2552
01:50:02,276 --> 01:50:04,144
AND REALLY, DR. KRAEMER, I CAN'T

2553
01:50:04,144 --> 01:50:06,313
THANK YOU ENOUGH FOR ALL OF THE

2554
01:50:06,313 --> 01:50:07,981
MENTORSHIP, ALL OF THE SUPPORT,

2555
01:50:07,981 --> 01:50:09,650
AND I KNOW THERE ARE MANY

2556
01:50:09,650 --> 01:50:11,051
STUDENTS OUT THERE JUST LIKE ME

2557
01:50:11,051 --> 01:50:14,388
WHO FEEL THE SAME WAY, AND THANK

2558
01:50:14,388 --> 01:50:18,092
YOU SO MUCH FOR EVERYTHING, AND

2559
01:50:18,092 --> 01:50:20,394
CONGRATULATIONS, AND I'M REALLY

2560
01:50:20,394 --> 01:50:24,465
EXCITED FOR WHAT'S TO COME.

2561
01:50:24,465 --> 01:50:34,641
>> HI, EVERYONE.

2562
01:50:34,641 --> 01:50:35,476
[VIDEOS REPLAYING]

2563
01:50:35,476 --> 01:50:37,244
>> I DON'T KNOW HOW TO GO
--

2564
01:50:37,244 --> 01:50:38,479
OKAY, AND THEN THESE ARE JUST

2565
01:50:38,479 --> 01:50:44,551
SOME MORE PICTURES FROM THE SIB

2566
01:50:44,551 --> 01:50:45,185
CONFERENCE, AND A PICTURE THAT

2567
01:50:45,185 --> 01:50:47,721
WAS TAKEN ACTUALLY BY ONE OF OUR

2568
01:50:47,721 --> 01:50:49,256
PEDIATRIC PATIENTS DURING THE

2569
01:50:49,256 --> 01:50:52,759
FAMILY WRAP UP AT NIH AND THEN

2570
01:50:52,759 --> 01:50:53,627
MORE PICTURES FROM THE

2571
01:50:53,627 --> 01:50:55,062
CONFERENCE.

2572
01:50:55,062 --> 01:50:56,396
SO THAT IS ALL I HAVE.

2573
01:50:56,396 --> 01:50:58,165
THANK YOU ALL!

2574
01:50:58,165 --> 01:51:05,105
[APPLAUSE]

2575
01:51:05,105 --> 01:51:07,941
>> THANKS, JENNIFER.

2576
01:51:07,941 --> 01:51:09,676
BEFORE WE MOVE TO THE CAKE AND

2577
01:51:09,676 --> 01:51:12,146
TAKE PICTURES, I JUST WANT TO

2578
01:51:12,146 --> 01:51:13,780
SHOUT OUT A THANK YOU TO

2579
01:51:13,780 --> 01:51:15,749
CHARLENE FOR PUTTING TOGETHER

2580
01:51:15,749 --> 01:51:17,151
ALL THESE THINGS AND TIRELESS

2581
01:51:17,151 --> 01:51:20,554
EFFORTS.

2582
01:51:20,554 --> 01:51:20,754
AND --

2583
01:51:20,754 --> 01:51:21,355
[APPLAUSE]

2584
01:51:21,355 --> 01:51:24,525
>> AND THE LCBG STAFF FOR
ALL

2585
01:51:24,525 --> 01:51:27,628
THE BALLOONS AND DECORATIONS,

2586
01:51:27,628 --> 01:51:28,395
COORDINATING ALL THE FOOD,

2587
01:51:28,395 --> 01:51:29,596
WITHOUT THEM THERE WOULDN'T BE A

2588
01:51:29,596 --> 01:51:30,697
PARTY HERE, SO THANK YOU ALL FOR

2589
01:51:30,697 --> 01:51:33,901
THAT.

2590
01:51:33,901 --> 01:51:44,077
[APPLAUSE]

2591
01:51:45,946 --> 01:51:56,123
>> [INAUDIBLE]