GOOD AFTERNOON, EVERYONE. I'M TOM STACKHOUSE ASSOCIATE DIRECTOR OF THE TECHNOLOGY TRANSFER CENTER AT THE NATIONAL CANCER INSTITUTE. I WILL BE YOUR HOST FOR THE DAY FOR MOST OF IT AND FIRST I WOULD LIKE TO WELCOME EVERYONE TO THE CEREMONY, NOT ONLY THOSE IN THE ROOM BUT ALSO THOSE WHO ARE ON THE VIDEOCAST. WELCOME. THIS PROGRAM IS IN HONOR OF THE WINNING TEAMS FROM THE BUSINESS PLAN PHASE OF THE BREAST CANCER START UP CHALLENGE. PLEASE NOTE IN YOUR PROGRAM THAT THERE'S BEEN A CHANGE, DR. LOWY WAS UNABLE TO JOIN US FOR THE KICKOFF OF THE PROGRAM HOWEVER IT IS MY GREAT PLEASURE TO INTRODUCE YOU TO BRIAN CIVIC, HE IS CHIEF TECHNOLOGY OFFICER FOR THE DEPARTMENT OF HEALTH AND HUMAN SERVICES. IN HIS ROLE AS TTO, HE IS RESPONSIBLE FOR HELPING HHS LEADERSHIP HARNESS THE POWER OF DATA, TECHNOLOGY AND INNOVATION TO IMPROVE THE HEALTH AND WELFARE OF THIS NATION. BRIAN HAS DISTINGUISHED HIMSELF AS SOMEONE WHO WORKED CREATIVELY ACROSS THE LARGE GOVERNMENT ORGANIZATION TO IDENTIFY AND IMPLEMENT THE BEST OPPORTUNITIES FOR IMPROVING THE WAY THE GOVERNMENT WORKS. PLEASE JOIN ME IN WELCOMING BRIAN CIVIC AS HE PROVIDES HIS VIEW OF THIS NEW INITIATIVE. [ APPLAUSE ] >> HEY, EVERYBODY, IT'S ALWAYS REALLY EMBARRASSING TO HEAR AN INTRODUCTION LIKE THAT BUT I REALLY APPRECIATE IT. THANK YOU SO MUCH FOR HAVING ME TODAY. SO AS WAS MENTIONED MY NAME IS BRIAN, I'M CHIEF TECHNOLOGY OFFICER FOR HEALTH AND HUMAN SERVICES BUT I'M ALSO ENTREPRENEUR AND RESIDENCE AT THE DEPARTMENT AND I LIKE THAT TITLE BETTER. IT GIVES ME MORE FLEXIBILITY AND FREEDOM TO DO A FEW THINGS THAT CTO MIGHT NOT NECESSARILY DO. AND ONE OF THOSE CONTEXTS, WE HAVE RECENTLY KICKED OFF A NEW ENTERPRISE AT THE DEPARTMENT THAT WE'RE CALLING THE IDEAL APP, IT STANDS FOR INNOVATION, DESIGN, ENTREPRENEURSHIP AND ACTION. I KNOW WHAT YOU'RE PROBABLY THINKING WHICH IS THAT MANY OF THOSE WORDS ARE SORT OF THE ULTIMATE PARADOXS WHEN COMBINED WITH GOVERNMENT. NOT MANY PEOPLE THINK ABOUT INNOVATION AND GOVERNMENT IN THE SAME SENTENCE FOR EXAMPLE, BUT YOU KNOW ONE OF THE THINGS I THINK WE CAN RECOGNIZE HERE AT NCI AND NIH IS THAT INNOVATION AND GOVERNMENT HAS ACTUALLY BEEN ONE OF THE THINGS THAT'S DRIVEN THIS COUNTRY FORWARD OVER MANY, MANY DECADES. A LOT OF THE STUFF YOU SEE AROUND YOU IN THIS ROOM TODAY WOULD NOT BE POSSIBLE WITHOUT GOVERNMENT FUNDING, GOVERNMENT INTERVENTION, GOVERNMENT RESEARCH. AND ONE OF THE THINGS I LEARNED AS I WAS PREPARING FOR THIS EVEN IS THAT THERE ARE OVER 18,000 INVENTIONS THAT ARE STILL ON THE SHELVE JUST AT THE NCI ALONE THAT ARE READY FOR COMMERCIALIZATION, THAT'S AMAZING. 18,000 POTENTIAL OPPORTUNITIES FOR DOING INTERESTING THINGS, CHANGING THE WAY THE WORLD WORKS IN SOME WAY, SHAPE OR FORM. AND I THINK YOU KNOW ONE OF THE THINGS THAT'S ALWAYS INTRIGUED ME IS THIS IDEA OF SERENDIPITOUS CLIEWGZ, BRINGING PEOPLE TOGETHER IN THE SAME PLACE WITH DIFFERENT BACKGROUNDS AND LETTING THEM TO THINK ABOUT A SINGLE PROBLEM AND BRING THEIR EXPERIENCE TO SOLVE A PROBLEM AND I THINK THAT TODAY, THE EVENT TODAY IS AN AFFIRMATION OF THAT. WE HAVE A BUNCH OF DIVERSE TEAMS WHO COME TOGETHER AROUND SPECIFIC CHALLENGES TO SOLVE SPECIFIC PROBLEMS AND I THINK IT'S AN AFFIRMATION ALSO ABOUT THE VALUE THIS TAXPAYER SPONSORED RESEARCH ACTUALLY HAS TO BRING TO THIS WORLD WHERE WE CAN IMAGINE DRAMATIC CHANGES LEADING TO BREAK THROUGHS AND LEADING TO NEW COMPANIES AND ORGANIZATIONS THAT CAN DO INTERESTING THINGS. THE THING IS, YOU KNOW IF WE DON'T STOP--IF WE STOP AT THE POINT OF JUST INVESTING THINGS AND KEEP THINGS ON THE SHELF WE NEVER REALLY GET ANYWHERE. SO WE NEED THESE NEW WAYS TO ENGAGE PEOPLE TO TAKE THESE NEXT STEPS TO DO INTERESTING THINGS AND I THINK THAT'S WHERE A LOT OF YOU COME IN. SO I'M CURIOUS, WHICH ONES ARE FROM THE TEAMS, OVER HERE. OKAY, GOOD SO I CAN LOOK AT ALL OF YOU AS I SAY THIS. SO I READ AN ARTICLE IN THE HARVARD BUSINESS REVIEW, RECENTLY THAT BASICALLY SAYS AN ENTREPRENEUR HAS THREE ROLES. FIRST THE ROLE IS THAT OF AN ARCHITECT, SORT OF A BIG PICTURE VISIONARY. SOMEBODY WHO CAN SET THE VISION, DEFINE THE CULTURE, BRING ROMANCE AND SEXINESS TO AN IDEA TO A VENTURE. SECOND AN ENTREPRENEUR HAS TO BE A STORY TELLER, HAVE YOU TO BE ABLE TO SELL THE IDEA, TAKE THE CONCEPT, TAKE WHAT YOU ARE TRYING TO DO IS CONVINCE PEOPLE THAT--WHO MIGHT NOT KNOW ANYTHING ABOUT IT AND TO TAKE A CHANCE AND TAKE THE NEXT STEP WITH YOU AND THIRD, THESE THINGS ARE ACTUALLY SOMETIMES VERY MUCH OPPOSED IN THE SAME PERSON, HAVE YOU TO BE A DISCIPLINEARIAN. YOU HAVE BE THE EXECUTOR. THE PERSON WHO CAN ACTUALLY BE VERY, VERY FOCUSED ON ACTUALLY DOING AS OPPOSE TO JUST THINKING THE BROAD THOUGHTS. BUT, I WANT TO ADD ONE MORE THING TO THAT, AND THIS COMES WITH I THINK REALLY MY PAST EXPERIENCE WHICH IS ALSO AN ENTREPRENEUR, I STARTED A COUPLE COMPANIES IN 97, BACK IN THE DAY AND I THINK THAT LAST PIECE IS THAT OF CATALYSTS. IF YOU LOOK AT THE THINGS THAT WE TYPICALLY EXPERIENCE, THE WAY WE TYPICALLY EXPERIENCE THE WORLD TODAY, IT'S VERY, VERY, DIFFERENT FROM HOW WE USED TO JUST 10 YEARS AGO. 10 YEARS AGO, THE ONLY WAY I COULD KEEP UP WITH MY FRIENDS WAS BY PICKING UP THE PHONE ASK CALLING THEM OR RUNNING INTO THEM IN PERSON OR MAYBE EVEN THROUGH E-MAILS OR GOD FORBID, ACTUAL LETTERS WE SENT THROUGH THE POST, RIGHT? BUT TODAY, YOU KNOW THANKS TO PEOPLE LIKE MARK ZUCKERBERG AND OTHERS, I KNOW THAT MY BUDDY JUSTIN HAD A BAD EGG AT BREAKFAST THIS MORNING, NOT THAT I NEEDED TO KNOW THAT BUT I CAN FIND THESE THINGS OUT IN A MUCH DIFFERENT WAY. BUT IT'S NOT JUST ABOUT THE SOCIAL STUFF. IT'S NOT ABOUT THAT KIND OF THING. IT'S MORE IMPORTANT AND MEANINGFUL THINGS AS WELL AND HEALTHCARE IS THE ONE I'M FOCUSED ON IN THIS ROLE BUT WHEN YOU THINK ABOUT THING LIKE WEARABLE TECHNOLOGIES, HOW MANY HAVE DEVICES ON THEM AS WE SPEAK? I'M KIND OF A GEEK WHEN I COME TO THIS STUFF. I HAVE AT LEAST THREE THINGS ON ME AT ANY GIVEN TIME BUT THAT'S ONE EXAMPLE, PREDICTIVE ANALYTICS INTO MEDICAL RECORDS ARE GOING TO FUNDAMENTALLY CHANGE THE WAY THAT PROVIDERS PRACTICE MEDICINE AND DO POPULATION HEALTH AND SO, YOU KNOW WE ARE CHANGING HEALTHCARE, RIGHT? THAT'S WHY WE'RE ALL HERE TODAY. THERE ARE 10 TEAMS WHO COME TOGETHER WHO PARTICIPATED IN THIS CHALLENGE, TAKE 10 DIFFERENT INNOVATIONS FROM THE NATIONAL CANCER INSTITUTE AND BUILT A BUSINESS PLAN TO GO AHEAD AND COMMERCIALIZE THESE IDEAS AND I THINK THIS IS CRITICALLY IMPORTANT BECAUSE WHAT'S GOING TO HAPPEN IS THAT WE HAVE THE ABILITY NOW, AND YOU KNOW IF WE LOOK AT THE STATISTIC, NOT EVERYONE WILL BE SUCCESSFUL RIGHT? THAT'S OKAY. WE LEARN JUST AS MUCH OFTEN FROM THE THINGS WE DO THAT AREN'T SUCCESSFUL FROM THE THINGS THAT WE DO THAT ARE, THAT'S THE KEY, BEING ABLE TO ADJUST RAPIDLY AND LEARNING WHAT'S WORKING AND NOT WORKING AND ITERATING QUICKLY AND CHANGING THE WAY YOU GO SO A BUSINESS MODEL AND PLAN THAT GETS DEFINED TODAY. I CAN ALMOST GUARANTEE YOU THAT OF THE 10 TEAMS A GOOD NUMBER OF THEM WILL APPROACH THESE PROBLEMS IN A VERY DIFFERENT WAY 12 MONTHS FROM NOW. BUT THERE'S ZERO PROBLEM WITH THAT. IN FACT THAT'S THE ONLY WAY TO DO IT. SO, YOU KNOW THIS IS--THIS THE TIME TO DO THIS STUFF AS I THINK WE'RE SEEING, EVERYTHING IN HEALTHCARE IS CHANGING TODAY FROM THE WAY THAT WE PAY FOR HEALTHCARE TO THE WAY THAT WE ACTUALLY INTERACT WITH OUR HEALTHCARE TO THE WAY THAT HEALTHCARE IS ACTUALLY PERFORMED ON US AND SO, THIS IS REALLY THE TIME TO DO THIS STUFF. SO I JUST WANT TO CLOSE HERE BY ACKNOWLEDGING THE FOLKS THAT HAVE WORKED REALLY HARD TO PUT THIS ON. AND SPECIFICALLY THE LEADERSHIP AND THE RISK TAKING THAT MARK HOLBERG AND THE FOLKS AT AVON FOUNDATION HAVE UNDERTAKE TONE WRITE THIS EFFORT. AND THANK YOU VERY MUCH. CONGRATULATIONS. THIS IS AN AWESOME COMPETITION AND A REALLY INTERESTING MODEL FOR POTENTIALLY TAKING TECHNOLOGIES THAT HAVE YET TO BE COMMERCIALIZED AND FIGURE OUT HOW TO COMMERCIALIZE THEM SO PERSONALLY I'M INCREDIBLY INTERESTED IN LEARNING WHAT HAPPENS AND I'LL SAY, YOU KNOW I'VE DONE THIS A COUPLE OF TIMES IF THERE'S ANY ADVICE I CAN OFFER IN ANY WAY, SHAPE OR FORM, DROP ME AN E-MAIL, TWEET AT ME WHATEVER AND WE WILL DO WHAT WE CAN TO HELP. THANK YOU FOR PARTICIPATING, THANK YOU VERY MUCH FOR DOING THIS AND THANKS FOR HAVING ME HERE TODAY. I APPRECIATE IT. [ APPLAUSE ] >> THANK YOU BRIAN. NOW IT'S MY PRIVILEGE TO INTRODUCE MARK HURLBERT WHO IS EXECUTIVE DIRECTOR OF THE AVON FOUNDATION FOR WOMEN AND AS NOTED ALREADY, AVON HAS GENEROUSLY SUPPORTED THE FUNDING OF THIS INITIATIVE, SO ... [ APPLAUSE ] >> THANK YOU TOM. I LIKE THE IDEA OF ENTREPRENEURIAL RESIDENCE THAT'S A GREAT TITLE. FIRST I WANT TO ACKNOWLEDGE AND THANK ALL THE BREAST CANCER SURVIVORS IN THE ROOM, THERE ARE SEVERAL WITH US TODAY AND I THINK--I HOPE YOU GET EXCITED BY THE INVENTIONS AND PROGRESS HERE BUT THIS IS FOR THE WOMEN THAT ARE FACING BREAST CANCER. THE AVON FOUNDATION FOR WOMEN IS DELETING GLOBAL FOUNDATION FOR WOMEN PROVIDING ALMOST A BILLION DOLLARS IN PROGRAMS WORLD WIDE TO END VIOLENCE AGAINST WOMEN AND TO END BREAST CANCER. OUR BREAST CANCER CRUSADE LAUNCHED IN 1992 IN THIS SHORT AMOUNT OF TIME WE DONATED ALMOST 815 MILLION TO FIGHT BREAST CANCER AND FUEL EXCITING BREAST CANCER RESEARCH. I THINK THAT AVON FOUNDATION WHEN WE WERE APPROACHED BY THE NCI AND THE CENTER FOR ADVANCING INNOVATION, WE SAW THIS AS AN OPPORTUNITY TO HELP TRANSLATE SOME OF OUR FUNDED ACADEMICS INVENTIONS, WE HAVE SOME OF THAT FROM CLEMSON AND OTHERS TODAY AND HELP TRANSLATE OUR FUNDED, ACADEMIC LAB, RESEARCH PART OF R&D TO GET IT INTO FURTHER DEVELOPMENT AND COMMERCIALIZATION. BECAUSE IF WE WANT PRODUCTS TO HELP PATIENTS AND WOMEN FACING CANCER THEY CAN'T SIT ON A BENCH. SO THIS CHALLENGE IS AN INNOVATIVE WAY TO MOVE FORWARD. THE AVON FOUNDATION HAS A LONG HISTORY OF PARTNERING WITH THE NATIONAL CANCER INSTITUTE AND A FEW YEARS AGO WE PUT MONEY INTO A 30 MILLION DOLLAR BUCK EXPET 62 PHASE ONE AND TWO TRIALS WHICH WAS VERY CULTURE CONFIRMED SEASESFUL AND LED TO THE FORMATION OF A CONSORTIUM OF MULTICENTER CONSORTIUM DOING TRANSLATIONAL BREAST CANCER RESEARCH AND IT IT'S SPEAR HEADED AT JOHNS HOPKINS UNIVERSITY NEARBY WHERE WE ARE TODAY. SO WE'RE THRILLED TO PARTNER WITH AVON AND THE NEWEST CENTER, THE CENTER FOR ADVANCEMENT AND INNOVATION, THEY'VE DONE A REMARKABLE JOB CONCEIVING THIS CHALLENGE. WE APPRECIATE THE INVENTORS THAT HAVE JOINED US AND THE TEAMS THAT HAVE JOINED US. IT'S REALLY--IT'S REALLY SOMETHING AT THE AVON FOUNDATION, I'VE BEEN LEADING THE PRELIMINARYS FOR ALMOST--PROGRAMS FOR ALMOST 10 YEARS AND WE'VE INVENTED A FEW PROGRAMS. AND WHEN YOU'RE LAUNCHING A PROGRAM, IT'S INVENTING THE WHEEL OF HOW DO YOU DO THIS BEST, IT DOESN'T FIT INTO THE RO-1 OR MECHANISM OR BRING IN ENTREPRENEURS OR BUSINESS EXPERMITS SO GREAT JOB TO NCI AND CENTER FOR ADVANCEMENT AND THE TEAMS SO THANK YOU FOR BEING HERE AND WE LOOK FORWARD TO HEARING FROM THE PARTICIPANTS. [ APPLAUSE ] >> THANKS MARK SO NOW I WOULD LIKE TO TAKE THIS OPPORTUNITY TO TALK TO YOU A LITTLE BIT ABOUT MY EXPERIENCES WITH THE CHALLENGE AND MAYBE A BIT ABOUT HOW IT CAME TO BE. THIS CHALLENGE MOVING FROM CONCEPTION INTO REALITY BEGAN TO TAKE SHAPE AND TOUCH MANY FACETS OF IMPORTANT TO THE MISSION OF NMH. IT PROVIDES A NEW PLATFORM FOR STUDENT LEARNING. SEIVET% OF OUR TEAM ENTRANTS WERE LED BY GRADUATE, UNDERGRADUATES POST DOCS AND MEDICAL REDENSES. IT CREATED A NEW MODEL BY WHICH THE FEDERAL GOVERNMENT AND ORGANIZATIONS MIGHT CONSIDER FOR DEVELOPING AND XECIALIZING THE IMPORTANT DISCOVERIES THAT ARE MADE IN THEIR LABS. IT HAS THE POTENTIAL TO STIMULATE THE ECONOMY BY CREATING STRONG START UP COMPANIES AND MOST IMPORTANTLY, THESE TECHNOLOGY VS THE POTENTIAL TO SIGNIFICANTLY AND POSITIVELY IMPACT THE PUBLIC HEALTH. I THOUGHT I WOULD PROVIDE A BRIEF OVER VIEW OF HOW THIS CHALLENGE CAME TO BE. NCI WAS LOOKING TO BETTER UNDERSTAND THE COMMERCIAL POTENTIAL OF THE PATENTS, THE PORTFOLIO AND AS YOU HEARD EARLIER WE HAVE QUITE A FEW PATENTS. WE ALREADY SET UP A SCIENTIFIC OVERSIGHT OVER THE PORTFOLIO BUT WE WERE LITERALLY LOOKING TO FIND A WAY TO BUILD IN THE BUSINESS ASPECT OF IT. I METROS MARIE TRUMAN BECAUSE SHE HAD BEEN WORKING WITH OUR NIH OFFICE OF TECHNOLOGY TRANSFER AND SHE PROPOSED THAT SHE COULD HELP US WITH OUR PORTFOLIO AND SHE COULD APPLY OVER A HUNDRED DIFFERENT BUSINESS TYPE FILTERS TO OUR PORTFOLIO TO HELP US PRIORITIZE IT. SO WE ENTERED INTO A PARTNERSHIP, INTERMEDIARY AGREEMENT WITH RESOURCES MA--ROSEMARIE'S GROUP, AND HER TEAM BEGAN IT--TO ASSIST US IN OUR PORTFOLIO AND A FEW MONTHS INTO THE PROJECT, ABOUT MARCH 2013 SO ABOUT A YEAR AGO DURING ONE OF OUR REGULAR CONFERENCE CALLS WE'RE HAVING, THE TWO OF US HAD THE A DISCUSSION ABOUT THE POTENTIAL OF CREATING A START UP CHALLENGE. AND THIS WAS JUST SOMETHING THAT WAS EXCITING TO ME AND WHEN I REACHED OUT TO NCI MANAGEMENT, THERE WAS A LOT OF EXCITEMENT THAT IMMEDIATELY CAME ABOUT, IN TALKING ABOUT IT SO WE--WE STARTED TO MOVE IN THAT DIRECTION. DEVELOP THE IDEA AND THE FOCUS ON BREAST CANCER, CAME ABOUT BECAUSE ROSEMARIE WAS DOING WORK WITH THE AVON FOUNDATION AND SO WHEN WE MENTIONED THIS TO MARK HURLBERT HE RECOGNIZED IMMEDIATELY THE INNOVATIVE POTENTIAL AND WE JOINED FORCES SO THE AVON FOUNDATION TOGETHER WITH THE NCI AND THE CENTER FOR ADVANCING INNOVATION, BECAME THREE STRANDS MUCH STRONGER THAN JUST THE TWO. WITH THAT GENEROUS SUPPORT FROM AVON, OUR TEAMS MOVED INTO EXECUTION WITH THE TREMENDOUS SPEED. YOU SEE MOST OF THESE CHALLENGES THAT ARE OUT THERE, THERE ARE VARIOUS TYPES OF CHALLENGES OUT THERE RELATED TO WRITING BUSINESS PLANS BUT THIS--MOST OF THEM GET START INDEED THE FALL. AND THEY ANNOUNCE THEM IN THE SPRING. SO AT THIS POINT, WE WERE ALREADY BEHIND THE EIGHT BALL SO TO SPEAK. WE HADN'T EVEN PLANNED OUT WHAT WE WERE GOING TO DO. SO ROSEMARIE ENDED UP KICKING US INTO HIGH GEAR TO PLAY CATCH UP AND WE HAD 154 MEETINGS WITHIN FIVE WEEKS WITH UNIVERSITIES AND OTHER POTENTIAL STAKEHOLDERS. WE WERE SOCIALIZE THANKSGIVING CHALLENGE. WE WERE GAINING NEW INSIGHT IN HOW TO DESIGN IT AND PUT IT TOGETHER WITH THESE DIFFERENT GROUPS AND FINALLY WE'RE READY TO LAUNCH OCTOBER 1st AND THE GOVERNMENT SHUT DOWN. [LAUGHTER] SO WE MISSED OUR KICKOFF CEREMONY BUT HERE WE ARE TO CELEBRATE ANYWAY. WE MOVE FORWARD ANYWAY. I HAVE NEVER SEEN AN INITIATIVE OF THIS MAGNITUDE ORGANIZED AND LAUNCH INDEED SUCH A SHORT TIME FRAME AND HONESTLY THERE ARE MANY TIME WHEN IS I TRULY THINK THAT ROSEMARIE DID NOT SLEEP FOR DAYS. BUT THE PURPOSE BEHIND THE EFFORT, IT'S ALL WORTH IT. EACH ONE OF US HAVE BEEN TOUCHED BY CANCER AND WHEN THIS PROJECT BEGAN TO MOVE INTO THE REALM OF BREAST CANCER SPECIFICALLY, IT TOUCHED HOME FOR ME. WHEN MY BEAUTIFUL WIFE OF NOW 28 YEARS WAS DIAGNOSED WITH BREAST CANCER NEARLY FOUR YEARS AGO, WE EXPERIENCED THAT GUT WRENCHING FEAR THAT IS FAR TOO COMMON PLACE FOR THIS DISEASE. BY GOD'S GRACE AND THE GIFTS HE PROVIDES ALL THOSE WHO WORK IN THE SCIENTIFIC MEDICAL FIELDS, SANDY IS A BREAST CANCER SURVIVOR AND IS HERE WITH US TODAY, SITTING BACK THERE. AND SO I'M VERY THANKFUL TO BE ABLE TO TURN TO HER AND SAY, THANK YOU SANDY FOR SUPPORTING ME THROUGH ALL THE LONG HOURS, THE UPS AND DOWNS OF PUTTING THIS CHALLENGE TOGETHER, YOU ARE MY ROCK AND I AM SO BLESSED TO HAVE YOU IN MY LIFE. AND THERE ARE SO MANY OTHERS, SO MANY OTHERS THAT ARE DESERVING OF THIS THANKS FOR THIS EFFORT, ON BEHALF OF HOSE MARY I WOULD LIKE TO THANK MARK HURLBERT AND THE AVON FOUNDATION FOR THIS CHALLENGE. WE WOULD LIKE TO THANK THE TEAM MEMBERS, SUPPORTERS AND OUR INTERNAL TEAMS WHO VERY OTHER ENORMOUS EFFORTS PUTTING TOGETHER THE CEREMONY WAS AN AMAZING FEAT TO WATCH AND BE A PART OF. WHILE THERE ARE MANY WHO ASSISTED THIS CHALLENGE ALONG THE WAY, I WANT TO GIVE THANKS TO SEVERAL WHO HAVE REALLY BEEN AT THE FRONT LINE FROM THE START. YOHAN WANG AND JONATHAN LUKE FROM C. A. I. AND RESOURCES FIELD AND JOHN HUGHS FROM THE NCI TRANSFER TECHNOLOGY CENTER. ERIC KALE FROM THE CANCER RESEARCH CENTER AT NCI. JENNY WONG FROM THE OFFICE OF TECHNOLOGY TRANSFER. THESE FOLK VS BEEN EXTREMELY SUPPORTIVE AND HELPFUL THROUGHOUT THE WHOLE CHALLENGE. THIS PROJECT TRULY OPENED MY EYES TO THE AMAZING TALENT AND DEDICATION OF PEOPLE WITHIN THE WALLS OF NIH, CAI AND THE AVON FOUNDATION AND MANY INSTITUTION WEES REACH THE OUT TO FOR THE TEAMS IT HAS REALLY TRULY BEEN AN HONOR TO WORK WITH YOU ALL. BUT TODAY WE'RE HERE TO CELEBRATE THESE TEAMS WHO FROM THERE DEDICATION AND HARD WORK COME FROM THE CHALLENGE, CHENCH AS BUSINESS PLAN PHASE AS BRIGHT SHINING STARS. TO EACH OF YOU, WE OFFER CONGRATULATIONS AND I AM EXCITED TO SEE THE ENTHUSIASM OF THESE TEAMS AS THEY STEP UP TO THIS CHALLENGE. IT'S A CHALLENGE TO IMPROVE THE STANDARD OF CARE AND SURVIVAL FOR CANCER PATIENTS. I ALSO BELIEVE THESE TEAMS ARE LEADING THE WAY WITH A NEW MODEL THAT WILL ACCELERATE AND INCREASE THE VOLUME OF TECHNOLOGY COMMERCIALIZATION ESPECIALLY FROM THAT TREASURE TROVE OF INVENTIONS WITHIN THE FEDERAL LABORATORIES. NOW I WILL HAND THE CEREMONY OVER TO ROSE MARY TRUMAN AND SHE WILL PROVIDE METRICS ASSOCIATE WIDE THE CHALLENGE AND TALK ABOUT THE NEW OPPORTUNITIES THAT THE CHALLENGE PRESENTS. ROSEMARIE? [ APPLAUSE ] >> HI, THERE, THANK YOU VERY MUCH AND I ALSO WANT TO REITERATE MY THANKS TO THE AVON FOUNDATION, MARK AND TOM FOR HAVING FAITH THAT WE COULD PULL THIS OFF AND WE HAVE DONE IT. AND SO I WANT TO START OUT WITH THE ENORMOUS OMOUNT OF EFFORT THAT THESE TEAMS PUT FORTH. I WAS INCREDIBLY IMPRESSED BY THE BUSINESS PLAN, THE FINANCIAL MODEL, REGULATORY STRATEGIES, COMMERCIALIZATION PLANS, DEVELOPMENT PLANS YOU ALL PUT TOGETHER AND YOU ALL KNOW THAT I'VE BEEN INTERACTING WITH YOU A LOT SO I HAVE A LOT OF RESPECT FOR ALL OF YOU AND VERY PROUD OF ALL OF YOU. SO I WANT TO LET EVERYONEq KNOW ABOUT WHAT DO THESE TEAMS HAVE TO DO SO AT FIRST WHETHER THEY HAD TO DO WAS ENTER WHAT'S CALLED THE LETTER OF INTENT PHASE. SO THE LETTER OF INTENT PHASE WAS ONLY PUTTING TOGETHER A TEAM. NOW ONLY PUTTING TOGETHER A TEAM. IS IT JUST THAT EASY? LIKE, YOU KNOW? SNAP YOUR FINGERS. THERE ARE 200 TEAMS THAT WANT TO ENTER AND 46 MADE IT. SO IN THE LETTER OF INTENT, THE TEAM HIS TO HAVE MEDICAL AND SCIENTIFIC TALENT, LEGAL EXPERTISEOT TEAM, THEY HAD TO HAVE LIFE SCIENCES, BUSINESS OPERATIONS AND A SEASONED ENTREPRENEUR. SO A SEASONED ENTREPRENEUR, YOU CAN'T FIND THEM LYING AROUND SOMEWHERE, IT'S HARD TO RECRUIT THEM. THEY'RE PRETTY BUSY PEOPLE AND THEY HAD TO HAVE ACTUALLY LAUNCHED A LIFE SCIENCES COMPANY AND BEEN WITH THAT COMPANY FOR THREE YEARS AND RAISED NONDILUTIVE CASH. SO PROVE O AGAIN FOR GETTING INTO THE CHALLENGE. THE NEXT PHASE OF THE CHALLENGE WAS A BUSINESS PLAN PHASE. SO WE ACTUALLY HAD A ROLLING START. A ROLLING START TO THE CHALLENGE, WHICH MEAN WHEN IS THE TEAM GOT IN, THEY ACTUALLY WERE ALLOWED TO START TO WORK ON THEIR BUSINESS PLAN PHASE. IN THIS PHASE, THE CHALLENGE, THEY HAD TO WRITE A 10 PAGE BUSINESS PLAN, SO I DON'T KNOW HOW MANY PEOPLE IN THE AUDIENCE HAVE WRITTEN BUSINESS PLANS BUT IT'S HARD TO WRITE A 10 PAGE BUSINESS PLAN, IT'S HARD TO WRITE THE 50 PAGE BELIEVES PLAN OR A 30 PAGE BUSINESS PLAN, BUT A 10 PAGE BUSINESS PLAN, I SAW THE INCREDIBLE AMOUNT OF FOCUS ON EVERY SINGLE WORD. FOLDED, PROBABLY AT TWO IN THE MORN OR SO. AS YOU WERE TRYING TO FIGURE OUT WHAT ARE THE BEST WORDS THAT ARE GOING TO GO IN THAT SENTENCE, SO THEY OFTEN DELIVER FINANCIAL MODELS TO SUPPORT THAT BUT IN THAT BUSINESS PLAN, THEY HAD A DEVELOPMENT PLAN, CURRENT AND FUTURE, THE HEAD OF A COMMERCIALIZATION STRATEGY, THE COMMERCIALIZATION STRATEGY HAD TO LOOK AT THE ENTIRE LIFE CYCLE OF THE INVENTION, SO WHICH TARGET MARKETS WILL THEY GO AFTER, WHEN DO THEY GO AFTER THEM. MULTIYEAR APPROACH. WE WANTED RISK ADJUSTED MPVs SO IT WASN'T AN EASY BUSINESS PLAN TO WRITE BY ANY STRETCH. THEN OF COURSE, WE HAD OUR PANEL OF JUDGES, THAT THEY DID LIVE PITCHES FOR SO, WE ALSO HAD FIVE MINUTE LIFE PITCH FOLLOW BIDE THREE-FIVE MINUTES OF QUESTION SPECIALIZATION OF SPECIFIC ENDOTHELIAL WE HAD AN INCREDIBLY TALENTED JUDGES POOL. MARK AND TOM WERE TWO JUDGES, MYSELF, BUT WE HAD KEEN JOLLY, SENIOR VICE PRESIDENT OF INNOVATION AT QUINN TILES, THEY'RE THE LARGEST CRO IN THE WORLD, THEY'VE DONE THE LARGEST NUMBER OF BREAST CANCER TRIALS IN THE WORLD. THIS GUY'S SPECIALTYY IS BREAST CANCER WE HAD NICK DEOFRIEO, I WORKED WITH HIM FOR YEARS AND CAROL, A VERY TALENTED ENTREPRENEUR THEY KNOW. SO THAT WAS AT BUSINESS PLAN PHASE, WHAT WERE THE RESULTS? AS I MENTIONED 200 TEAMS WANTED TO ENTER, 46 MADE IT IN AND WE WORK WIDE SOME TEAMS FOR WEEKS TO GET THEM TO GET THEIR TEAM IN PLACE SO THEY COULD GET IN. THE AVERAGE TEAM SIZE IS 10 PEOPLE SO THERE ARE 478 PEOPLE TOTAL IN THE CHALLENGE THAT INCLUDED VENTURE CAPITALISTS, THREE UNIVERSITY STUDENTS ON EACH TEAM WHO COULD HAVE BEEN POST DOCS OR PEOPLE IN RESIDENCIES AND A MYRIAD AS I MENTIONED LIFE SCIENCES BUSINESS OPERATIONS AND ENTREPRENEURS. IN TOTAL 4356 YEARS OF EXPERIENCE ACROSS THE TEAM. THE REASON WE KNOW THIS IS BECAUSE WE ASK AND WE CHECKED. SOPHISTICATED WE LOOKED AT RESUMES TO MAKE SHOULD THIS WAS ACCURATE. THANK YOU JONATHAN WHO IS ACTUALLY IN NEW YORK RIGHT NOW WHOA DID ALL THIS CHECKING FOR US. AND THAT MAKES ABOUT A HUNDRED YEARS OF EXPERIENCE FOR THIS TEAM. SO WHAT CAN I PROVIDE YOU WITH A FEW STATISTICS THAT I THOUGHT YOU MIGHT FIND INTERESTING. SO IN TERMS OF PARTICIPATION THERE WERE 83 UNIQUE UNIVERSITIES THAT DOES NOT INCLUDE ONE UNIVERSITY WITH FIVE DIFFERENT PARTS OF THEIR UNIVERSITY, WE DIDN'T COUNT THOSE AS SEPARATE UNIVERSITIES. THERE WERE 83 UNIVERSITIESOT TEAMS. THE TEAMS CAME FROM FIVE DIFFERENT COUNTRIES, INDIA, THE NETHERLANDS, NUCLEOTIDES NUCLEOTIDES--NEW ZEALAND, U. K., U.S. 20% OF THEM WERE OWS OF--OUTSIDE OF THE U.S. AND SO VERY GEOGRAPHICALLY DIVERSE. SO I WANT TO TAKE A MOMENT TO ACTUALLY RECOGNIZE THE WINNERS, SO IF YOU GUYS COULD STAND UP FOR A MOMENT. SO WASHINGTON UNIVERSITY IN ST. LOUIS. TULANE UNIVERSITY IS NOT HERE YET, I DON'T THINK? OH YEAH! COME UP HERE. HERE'S YOUR SEAT. SORRY. NOT TO PUT YOU ON THE SPOT OR ANYTHING LIKE THAT. YOU HAVE BEEN THROUGH ENOUGH THIS, IS THE EXTRA ROUND OF TORTURE. CLEMSON? RAISE YOUR HAND PLEASE? STANFORD UNIVERSITY? NORTHWESTERN? RUTGERS? IS RILEY HERE? OKAY. WAKE FOREST? SO MAYBE A FLIGHT WAS DELAYED. BERKELEY? GREAT. Mc GILL UNIVERSITY? THANK YOU. THANK YOU ALL FOR MUCH FOR ALL OF YOUR HARD WORK. [ APPLAUSE ] WE'LL BE GIVING YOU YOUR MONEY LATER, SO DON'T WORRY. SO I ALSO WANT TO MENTION THAT BENCHMARKS AGAINST THE LARGEST BUSINESS PLAN CHALLENGE IN THE WORLD WHICH IS CURRENTLY, HAS 42 TEAMS RUNNING FOR 13 YEARS THIS, CHALLENGE IS LARGER IN THE FIRST YEAR RUNNING SO WE'RE VERY PLEASED. I WANT TO--I WANT TO LEAVE YOU WITH A THOUGHT BEFORE YOU GO INTO THE NEXT SECTION WHICH IS SOMETIMES YOU HAVE TO COLOR OUTSIDE THE LINES. AND THAT'S KIND OF WHAT WE DID WITH THIS CHALLENGE. HOW ARE WE GOING TO MAKE THIS WORK? AND WE DID. SO THEN I WANT TO TALK TO YOU A LITTLE BIT ABOUT TAKING A STEP BACK FROM THE CHALLENGE, HOW THE BIG PICTURE OPPORTUNITY, THE BEST CHALLENGE PRESENTS A PLATFORM FOR IT. NUMBER ONE, OF COURSE, IN BREAST CANCER RESEARCH, IT'S GOING TO HOPEFULLY PRESENT, YOU KNOW NEW THERAPEUTICS VACCINES IHAVE FAITH IN ALL OF YOU, I WILL SEE ALL OF THEM ON THE MARKET, I KNOW IT TAKES TIME BUT I'LL BE WATCHING. BUT ALSO THERE'S A BIGGER PICTURE IMPACT ON THE U.S. ECONOMY. SO WE ACTUALLY DID A PROJECT FOR THE COSTMAN FOUNDATION AND IDENTIFIEDED OW BIG THAT OPPORTUNITY IS AND I WILL SHARE THAT AND THIRDLY THE PHILANTHROPY, THAT COULD CHANGE THE DYNAMICS WITH VENTURE PHILANTHROPY. SO AS YOU KNOW, THE PREVALENCE, YOU KNOW PEOPLE LIVING WITH BREAST CANCER IS ABOUT 2.8 MILLION PEOPLE IN THE WORLD. 232,000 A YEAR ARE DIAGNOSED AND ABOUT 39,000 PEOPLE DIE FROM BREAST CANCER IN A YEAR. WHEN WE WERE DOING THIS WORK WITH THE AVON FOUNDATION AND ALSO THE NCI ON THE PORTFOLIO ASSESSMENTS, WHAT WE FOUND WAS THAT YOU KNOW WE WERE TRYING TO FIND LICENSEES FOR THESE INVENTIONS. AND YOU KNOW PEOPLE SAID, OH WELL BREAST CANCER'S RELATIVELY WELL ADDRESSED, YOU KNOW WHY WOULD WE WANT TO INVEST IN ANYTHING THERE. AS CAN YOU SEE, IT'S NOT VERY WELL ADDRESSED. AND THE TREATMENTS THAT ARE ON THE MARKET ARE POISONOUS FOR THE MOST PART. SO THERE'S A VERY BIG OPPORTUNITY FOR YOU ALL TO TAKE THESE INVENTIONS AND CREATE NEW PRODUCTS THAT WILL CHANGE THE WORLD FOR BREAST CANCER SURVIVAL. DISCLOSURE FRAMEWORK FROM THE POINT OF THE U.S. ECONOMY RIGHT THIS MINUTE THERE ARE 120,000 INVENTIONS SITTING ON THE SHELF. SO WE ANALYZE 145 RESEARCH INSTITUTES IN THE UNITED STATES, THAT DOES NOT INCLUDE BY THE WAY, THE ONES WITHIN THE NIH. THESE ONLY INCLUDE THE ONES THAT ARE IN THE RESEARCH ORGANIZATIONS LIKE UNIVERSITIES, HOSPITALS, RESEARCH ORIENTED FOUNDATIONS. IF WE WERE TO ACTUALLY GET THE SIX% MORE OF THESE INVENTIONS OUT INTO THE WORLD THAT COULD BE BETWEEN 500 BILLION TO $1.5 TRILLION IMPACT ON THE ECONOMY. SO AGAIN, I HAVE NEVER HAD ANYONE LOOK AT MY NUMBERS LIKE THE KAUFMAN FOUNDATION HAS IN SO MUCH DETAIL SO THESE NUMBERS ARE VERY STRONG. TO TAKE IT TO THE NEXT LEVEL LET'S SAY THAT FIVE OF THESE--WE HAVE FINANCIAL MODELS FOR ALL OF THE INVENTIONS THAT ARE PART OF THIS CHALLENGE AND WE LOOKED AT OF COURSE MULTIPETRESSABLE INDICATIONS GOING TO MARKET AND THINGS OF THAT NATURE AND FIVE OF THE INVENTIONS THAT WE HAVEOT TABLE HERE THAT YOU WILL BE WORKING ON, CREATING YOUR START UPS AND RAISING FOOD CAPITOL AND SUCCESSFULLY NEGOTIATING LICENSE AT THE NIH AND CLEMSON. THEN WOULD EQUATE TO 12 BILLION, TO 25 BILLION IN ONE YEAR OF GDP IMPACT. IF YOU DO IT FROM THE BOTTOMS UP, LET'S JUST PRETEND .04% INVENTIONS ARE ACTUALLY OUT OF THE 120,000. BY THE WAY 120,000 IS A NUMBER THAT'S NOT CRACKED AS MUCH SMALLER BECAUSE WE COULD GET RELIABLE DATA FOR THE RESEARCH INSTITUTES IN THE UNITED STATES, SO WE WANT 10 YEARS OF SOLID DATA, PRIMARY, SECONDARY DATA COLLECTION AND MAKE SURE IT WAS CORRECT. 50 OF THOSE INVENTIONS WERE TO--WERE LIFE SCIENCES INVENTIONS AND BLOCK BUSTERS IN ONE YEAR, THAT WOULD BE 50 BILLION SO CAN YOU SEE THAT--YOU KNOW, IT DOESN'T TAKE THAT MUCH MORE TO GET TO THE 500 BILLION DOLLAR MARK. SO FOR THE U.S. ECONOMY, THIS MEANS A LOT OF JOBS, YOU KNOW, DISPOSABLE INCOME, ET CETERA. LASTLY, I SAID THERE ARE THREE OPPORTUNITIES, THE THIRD ONE IS REALLY THE PARADIGM SHIFT IN VENTURE FILL PHILANTHROPY FOR THE AVON FOUNDATION DOES AT THE VERY, VERY, IMPORTANT ROLE, WHAT THE NIH DOES AND VERY IMPORTANT ROLE IN SUPPORTING EARLY STAGE RESEARCH. HOWEVER, IF YOU THINK ABOUT IT FROM THE POINT OF VIEW OF AVON THIS, IS ACTUALLY--WELL, SAY THIS CORRECTLY, CAN YOU CORRECT ME IF I'M WRONG, THIS IS AN INCREDIBLYENTIOUS FICIENT USE OF MONEY FOR THE EQUIVALENT OF ONE GRANT, CAN YOU PUSH FORWARD UP TO 30 INVENTION, THIS HAD CASE WE HAVE 12 THAT ARE MOVING FORWARD BUT IT WAS UP TO 30. SO THAT'S REALLY AN AMAZING IDEA. IT'S ALSO A FIDUCIAR ILLEGALSY RESPONSIBLE IDEA SO JUST IMAGINE IF WE WERE ABLE TO INSTITUTIONALIZE THIS MODEL, IN FOUNDATIONS AND ALSO AT THE NIH. WE COULD GET A LOT MORE INVENTIONS OUT TO THE WORLD AND MAKING MORE PROGRESS. SO IF YOU THINK ABOUT THIS A LITTLE BIT MORE DEEPLY, AND THINK ABOUT, HAVE YOU TWO OPTIONS, YOU KNOW VENTURE CAPITALIST HAS TWO OPTIONS AND WHAT TO INVEST IN, ONE OPTION IS THAT THEY CAN INVEST IN THIS LITTLE TUBE THAT IS GOING--IT'S FOR SOME USE OF BREAST CANCER BUT IT'S NOT GOING TO REALLY DRAMATICALLY IMPACT THE LIFE OF A BREAST CANCER PATIENT. BUT IT'S FAST TO MARKET, LOW CAPITAL, IT'S VERY HIGH PROBABILITY OF SUCCESS. THIS LITTLE TUBE, NOT--I MEAN NOT GOING TO HAVE TO GO THROUGH FEDERAL FDA TRIALS OR THIS REALLY DIFFICULT, THERAPEUTIC THAT'S GOING TO HAVE MULTIYEARS IT'S HIGH--VERY CAPITAL INTENSIVE, IT'S HIGH RISK, SO WHAT WOULD A VENTURE CAPITALIST CHOOSE. NORMALLY THEY WOULD CHOOSE THE LITTLE TUBE, BUT THERAPEUTIC HOWEVER, HAS A LARGE IMPACT OR COULD HAVE A VERY LARGE IMPACT ON SAVING LIVES, AND TREATING PEOPLE BETTER. BUT FOR B. C. THE CHOICE WOULD BE MORE ABOUT THE LOW RISK OPTION, FASTER TO MARKET OPTION. SO THIS IS TRULY A HIGH STAKES SITUATION. AND IT'S--IT'S THE--IT'S THE NIH AND AVON FOUNDATION'S POSITION TO BE IN THESE SUPPORTING THESE HIGH STAKES INITIATIVES FOR A VERY, VERY IMPORTANT ESPECIALLY CANCER. SO MY GRANDMOTHER DIED FROM IT, MY FATHER DIED FROM IT, MY GREAT GRANDMOTHER DIE FRIDAY IT, I COULD GO ON. I HAVE VERY STRONG FOND MEMORIES OF MY FATHER, STILL MISS HIM TO DEATH THIS DAY. HE WAS A PROFESSOR OF PHYSICS AT HARVARD, DON'T HOLD THAT AGAINST HIM. SORRY IF ANYBODY'S FROM HARVARD. HE WORKED FOR NASA ON THE FIRST ROCKET PROPULSION ENGINE. HE TAUGHT ME HOW TO READ WHEN I WAS THREE AND HE ALSO TOUT ME HOW TO BLOW THINGS UP. [LAUGHTER] SO AS CAN YOU SEE THIS CONTEST REPRESENTED A VERY LARGE CHALLENGE TO OUR ENTREPRENEURS AND OUR NEWLY INCREASE THE NUMBER OF OINTED ENTREPRENEURS BUT IT IS CERTAINLY NOT A GAME. THANK YOU. [ APPLAUSE ] >> THANK YOU ROSEMARIE AND NOW IT'S MY PLEASURE TO INTRODUCE TO YOU LILLY SHOCKNEY. SHE IS A TWO TIME BREAST CANCER SURVIVOR HERSELF, WORKED TIRELESSLY TO IMPROVE THE CARE OF BREAST CANCER PATIENTS AROUND THE WORLD AND WHEN WE ACTUALLY INVITED HER TO SPEAK, SHE KINDLY REARRANGED HER SCHEDULE SO SHE COULD BE WITH US TODAY AND WE ARE VERY THANKFUL. [ APPLAUSE ] >> ARE YOUR HEARTS RACING OVER HERE? I CAN ALMOST FEEL THEM. ABSOLUTELY. WELL IT IS A PLEASURE FOR ME TO BE HERE WITH YOU TODAY AND SO WE KNOW THAT THERE ARE SEVERAL PEOPLE IN THE ROOM WHO ARE BREAST CANCER SURVIVORS AND I AM AMONG THAT GROUP. I'M A 22 YEAR BREAST CANCER SURVIVOR. I WAS DIAGNOSED IN MY 30S, NO KNOWN RISK FACTORS, NO FAMILY HISTORY. AND I UNDERWENT AT THAT TIME A MODIFIED RADICAL MASTECTOMY THAT PREDATED SENTINAL NODE BI OPTSIES AND ALSO HAD OTHER TREATMENTS FOR MY MULTIINVEIGHSIVE CARCINOMA AND I WAS NOT A CANDIDATE FOR RECONSTRUCTION DUE TO OTHER MEDICAL PROBLEMS I AND I WAS CONTENT WEARING BETTY BOP IN MY MASTECTOMY BRA AND I TREATED HER LIKE YOU DO YOUR AMERICAN EXPRESS CARD. I NEVER LEFT HOME WITHOUT HER. MY MOTHER WHO IS KNOWN FOR BEING A ROCK FELL APART ON ME WHEN SHE FOUND OUT I WAS DIAGNOSED AND I WASN'T EXPECTING THAT. IF YOU'RE HAVING A CRISIS, YOU CAN CALL MY MOTHER. SHE DOES NOT NEED TO KNOW YOU. SHE WILL SEE YOU THROUGH. SHE TELLS PEOPLE, I HOPE YOU CROSS THE STREET EVEN IF YOU DON'T WANT TO GO. BUT SHE WAS CONVINCED I WAS GOING TO DIE AND WHAT I DIDN'T KNOW IS THAT SHE HAD ALSO SHARED THAT CONCERN WITH OUR DAUGHTER LAURA WHO WAS 12. AND SHE HAD TOLD HER, I'M REALLY WORRIED THAT YOUR MOM DOESN'T GOING TO LIVE THROUGH THIS AND IF SO THEN POPPA PATHWAY GIVES AND AND I WILL BE RAISING YOU BECAUSE YOUR DAD IS AWAY DRIVING A TRACTOR TRAILER AND IS GONE A LOT. I DIDN'T FIND THAT OUT UNTIL MANY YEARS LATER. I ENDED UP GETTING DIAGNOSED IN MY OTHER BREAST AROUND 40. AND AGAIN I UNDERWENT A MODIFIED RADICAL MASTECTOMY. AND WAS ABLE TO DO RECONSTRUCTION SO WE HAD A CONTEST, RATHER THAN MY HUSBAND AND I CALLING PEOPLE AND SAYING LILLY'S BEEN DIAGNOSED AGAIN AND INSTEAD WE CALLED THAT SAID THAT BETTY BOP AND GETTING A ROOMMATE AND WE WANT TO CHOOSE A NAME AND THE NAME WAS SETTLED ON WAS BOBBY SUE, MY BOOBSY TWINS AND I COULDN'T FIGURE OUT HOW MY MOM WAS A ROCK BECAUSE I WAS NOW MORE WORRY THAT I HAD BREAST CANCER AGAIN BUT SHE SAID, --I SAW HOW YOU DEALT WITH THIS, I KNOW WHAT HAY FIGHTER YOU ARE, I UNDERSTAND THIS DISEASE BETTER AND I THINK I CAN MORE CONSTRUCTIVELY HELP YOU BECAUSE WHAT SHE THOUGHT SHE WOULD BE DOING IS GET ME BACK INTO HER UTERROUS, SOMETHING MUST HAVE GONE WRONG IN THERE AND YOU DID COME OUT EARLY SO SOMEHOW THIS MUST BE MY FAULT. SHE WANTED TO REACH OUT AND HELP OTHERS MOTHERS WHOSE DAUGHTER HIS BEEN DIAGNOSED AND SHE SAID, CAN YOU HELP ME MIND A VOLUNTEER ORGANIZATION THEY CAN PARTICIPATE IN. WELL, THIS WAS IN JANUARY 1995, WHEN YOU COULD ACTUALLY GO TO BARNS AND NOBLE BOOK STORE AND BUY A BOOK OF WEB SITES, URL ADDRESSES, CAN YOU IMAGINE THAT AND IT WASN'T A VERY THICK BOOK. THERE WERE THREE CANCER WEB SITES, JUST THREE. THEY DID HAVE POSTING WARS, I POSTED ON ALL THREE THE FOLLOWING, I AM LOOKING FOR AN ORGANIZATIONSIZATION TO MOTHERS WHO HAVE DAUGHTERS DIAGNOSE WIDE BREAST CANCER IF YOU KNOW OF SUCH AN ORGANIZATION WOULD YOU PLEASE E-MAIL ME BACK AT MY PERSONAL E-MAIL. 48 HOURS I WENT BACK ON TO THE INTERNET AND I FOUND 51 E-MAILS IN MY INBOX WHICH I WAS USE TO ONLY GETTING ONE OR TWO E-MAIL WAYS BACK THEN AND I THOUGHT GOOD GRIEVE THERE MUST BE A LOT OF SPIRIT AND I HAVE FAILED MY OWN MOTHER IN PROVIDING HER WHAT SHE NEEDED SO THAT SHE WASN'T DRIVING ME CRAZY WHILE I UNDERWENT TREATMENT. EACH ONE I OPENED BASICALLY SAID THE SAME THING, I DON'T KNOW OF AN ORGANIZATION BUT IF YOU FIND ONE WOULD YOU E-MAIL ME BACK FOR MY MOM. MY MOM'S A WRECK. SO I CALLED MY MOTHER AND I SAID MA, I HAVE FOUND AN ORGANIZATION THAT PROVIDES SUPPORTS TO MOTHER WHO IS HAVE DAUGHTERS WITH BREAST CANCER AND SHE SAID THAT'S WONDERFUL, WHERE IS IT? I SAID IT'S YOU, WE'RE GOING TO MAKE ONE. BECAUSE I AM NOT OF MIND NOR IT MY MOTHER TO SIT BACK AND WAIT FOR SOMEONE ELSE TO DO SOMETHING. IF THERE IS A NEED, I WILL TAKE IT ON, JUST AS THERE'S A NEED AND YOU WILL TAKE IT O. SO I TOLD HER, I SAID, YOU ALREADY HAVE 51 MOMS THAT NEED YOUR HELP RIGHT NOW. WITH THE SUPPORT OF ONE OF OUR SENATORS IN MARYLAND, WITHIN SIX WEEKS WE BECAME A NATIONAL NONPROFIT ORGANIZATION. MY MOTHER HAS MOTHER VOLUNTEERS ACROSS THE UNITED STATES THAT SHE MATCHES TO MOTHERS BASED ON THE CLINICAL PROFILE OF THE DAUGHTER. THEY HAVE A PARTICULAR TEAM OF MOTHERS WHO HAVE LOST THEIR DAUGHTERS TO THIS DISEASE ANDSœt THEY HANDLE BEREAVEMENT AND THAT'S ONE OF THE SADDEST THINGS WE'VE SEEN THAT THAT GROUP NEEDED TO DO. A FEW YEARS BACK, THERE WAS A LITTLE ARTICLE IN WOMAN'S DAY MAGAZINE ABOUT THE ORGANIZATION MOTHERS SUPPORTING DAUGHTERS WITH BREAST CANCER AND IT RESULTED IN MY MOM GETTING A COLLECT CALL FROM A WOMAN IN A NURSING HOME WHO IS 92 YEARS OLD. AND SHE CALLED AND SHE SAID, I JUST FOUND OUT MY BABY HAS BREAST CANCER. AND MY MOTHER SAID HOW OLD IS YOUR BABY AND SHE SAID 74. [LAUGHTER] AND SHE WAS HER BABY AND SHE SAID, I LIVE HERE IN KANSAS, MY DAUGHTER IS IN CALIFORNIA. I HAVE VERY BAD PARKINSON'S DISEASE, I USED TO WRITE LATE LETTERS TO--LETTERS TO HER ALL THE TIME BUT I CAN'T WRITE LETTERS, I CAN'T SEND HELP, AND I CAN'T SIT HERE AND NOT DO SOMETHING FOR MY BABY OR MY CHILD. SO MY MOTHER GOT POST CARDS, GOT THE DAUGHTER'S ADDRESS FROM THIS ELDERLY MOTHER, PRESTAMPED ALL OF THEM. PREADDRESSED ALL OF THEM AND THEN CALLED THE NURSE MANAGER AT THE NURSING HOME AND TOLD HER WHAT ONE OF THEIR RESIDENTS WAS DEALING WITH, THAT THIS WAS A MOTHER VERY WORRY BODY HER DAUGHTER AND SHE HELD HER RESPONSIBLE IN MAILING THOSE POSTCARDS TO HER AND SAID HELP THIS INDIVIDUAL. HELP THIS DEAR WOMAN THIS, MOTHER RIGHT JUST ONE SENTENCE A WEEK ON ONE OF THESE POST CARDS AND BE RESPONSIBLE TO DROP IT IN THE MAIL SO THAT HER DAUGHTER RECEIVES IT. AND THE WOMAN WOULD WRITE THINGS LIKE CHEMO THERAPY NUMBER TWO, DONE OH GOOD, I LOVE YOU, LOVE MOM. THE DAUGHTER A FEW MONTHS LATER CALLED MY MOTHER, NOT COLLECT THOUGH, AND SAID YOU HAVE NO IDEA WHAT HAVE YOU DONE FOR US AS A MOM AND DAUGHTER. I HAVEN'T SEEN MY MOTHER'S HAND WRITING FOR YEARS AND TO SEE IT AND TO READ WHAT SHE'S WISHING FOR ME, AND THAT HE'S SHE'S THERE SUPPORTING ME AND CHEERING ME ON, THANK YOU SO MUCH FOR DOING THIS FOR BOTH OF US. AND THE DAUGHTER CALLED TWO YEARS LATER AND SAID, I JUST WANT TO LET YOU KNOW THAT MY MOM DIED IN HER SLEEP, WE ARE BURYING HER WEARING HER PINK RIBBON PEN AND MY MOTHER CALLED ME AND SAID, SHE SOUNDED FINE WHEN SHE WASOT PHONE WITH ME TWO YEARS AGO, I DON'T KNOW WHAT HAPPENED. >> SHE'S 94 AND SHE DIED IN HER SLEEP. I THINK THEY SHOULD HAVE CHECKED SOMETHING. SHE WAS VERY ALARMED ABOUT THAT AND 11 YEARS AGO I EXPERIENCED SOMETHING I CONSIDER VERY AMAZING. WITH THE POWER OF SCIENCE AND INNOVATIONS THAT ALL OF YOU ARE GOING TO EMBARK ON DOING ON BEHALF OF BREAST CANCER SURVIVORS AND THOSE WHO END UP PATIENTS IN THE FUTURE, I AT LONG LAST BECAME A CANDIDATE TO HAVE BREAST RECONSTRUCTION DONE. NOW I DIDN'T HAVE CHOICE WITH EITHER TIME OF MY ORIGINAL SURGERIES AND OTHER TREATMENTS BUT NOW SUDDENLY CHOICE HAD BEEN RESTORED TO ME AND I STRUGGLE WIDE THIS DECISION. I TALKED TO MY HUSBAND, HE SAID PLEASE DON'T DO IT FOR ME. I DON'T WANT TO SEE YOU IN THE HOSPITAL AGAIN, YOU'VE BEEN IN AND OUT SO MANY TIMES. MY DAUGHTER WAS THE SAME WAY, MOM, DON'T DO IT, DON'T DO IT AND I SAID I REALLY DO NEED TO THINK ABOUT THIS BECAUSE I DIDN'T HAVE TO WORRY ABOUT IT BEFORE. I HAD BETTY BOP AND BOBBY SUE BUT NOW WITH CHOICE PRESENTED TO ME I HAVE TO THINK ABOUT THIS, SO THE TYPE OF PROCEDURE I WAS INTERESTED IN IS CALLED DEEP FLAP D. E. I. P., DEEP EPIY GHASTIN INFOR YORE PERERATOR, HIGH SOPHIST CAD PROCEDURE OF CUTTING YOUR ABDOMINAL FAT AND TRANSFERRING UP TO YOUR CHEST MPLET NO MUSCLE, VERY CLEVER PROCEDURE. I DECIDED I WOULD GO TO CHURCH MY MYSELF ON A SATURDAY EVENING. CHURCH WAS OPEN, NO ONE IN THERE THANK HEAVENS, I SAT THERE ON THE BACK PEW AND I SAID OUTLOUD, GOD, YOU GIVE ME A SIGN, IF IT'S OKAY WITH YOU THAT I PURSUE BREAST RECONSTRUCTION AND IF YOU NEVER GIVE ME A SIGN, THAT'S FINE. BECAUSE THE TWINS AND I ARE DOING FINE. I THOUGHT I'M NEVER GOING TO TELL ANYBODY THAT I DID THIS THAT I WENT TO CHURCH AND ASKED THIS OUTLOUD THERE, GOT OUT THERE TO MY CAR AND I'M LOOKING AROUND TO MAKE SURE NOBODY ELSE IS WATCHING ME. I DIDN'T THINK I WOULD SAY LIKE A BURNING BUSH OR YOU KNOW BE HIT BY LIGHTNING OR SOMETHING AND AS I WAS UNLOCKING MY CAR AND GETTING IN MY CAR, I'M NOT GOING TO TELL MY HUSBAND THAT I CAME HERE AND DID THIS, AND I CAN BE RESOLVED NOW TO NOT WORRY ABOUT MAKE MAKING THIS DECISION AND I TURNED ON MY IGNITION AND MY CAR RADIO WAS THAT WAS PLAYING AND THE SONGOT RADIO THAT I HAD NOT HEARD IN YEARS WAS SEXUAL HEALING BY MARVIN GAY AND THE FIRST FULL VERSE WAS, I CAN'T WAIT FOR YOU TO OPERATE, I'M YOUR MEDICINE, LET ME IN ... [LAUGHTER] I WENT HOME AND I SAID GOD JUST SANG SEXUAL HEALING TO ME ON MY CAR RADIO I'M GOING TO DO THE DEEP FLAP RECONSTRUCTION AND SO I DID. AND WHILE I WAS GOING TO SLEEP FOR THAT OPERATION, HAD HEAD PHONES ON AND THAT WAS THE SONG THAT I LISTENED TO. AND MY MOTHER SAID WHEN I AWAKENED AND PUT MY HANDS UP NEAR MY CHEST, I SAID THE GIRLS ARE BACK, MY SILHOUETTE HAS BEEN RESTORED FOR ME. MY DAUGHTER HAS DONE A LOT OF VOLUNTEER WORK WITH ME OVER THE YEARS. ONE OF THOSE PROJECTS THAT WAS A BIG PROJECT WAS HOLDING A GALA AS A MAJOR FUNDRAISER FOR OUR BREAST CENTER AND SHE OFFERED TO GO TO THE RADIO STATION AND BE INTERVIEWED WHICH WAS VERY STRAIGHT FORWARD QUESTIONS. THE NAME OF THE EVENT WHERE WAS THE MONEY GOING TO GO THAT WE RAISED FROM THE EVENT, WHERE WAS THE EVENT BEING HELD, WHAT TIME IS THE EVENT, THE DATE OF THE EVENT AND THE PHONE NUMBER FOR ANY QUESTIONS AND SO I'MOT HIGHWAY, LISTENING TO MY CHILD, WHO IS 26 AT THE TIME ANSWERING THESE VERY STRAIGHT FORWARD QUESTIONS. AND THEN I HEAR THE GUYOT RADIO SAY, BY THE WAY, I'M LIKE BY THE WAY ... THAT'S NOT ON MY LIST OF QUESTIONS, AND SAID I KNOW YOU'RE MOM'S HAD BREAST CANCER TWICE, ARE YOU CONCERNED ABOUT GETTING BREAST CANCER. I ABOUT WRECKED MY CAR. I COULDN'T EVEN BREATHE IN MY CAR. SHE SAID, I WORRY BODY IT WHEN I WAS A TEENAGER, I DIDN'T KNOW THIS. SHE SAID BUT I'M NOW IN MY MID20S, MY MOTHER HAS SHOWN ME HOW TO BEAT IT TWICE, I SURE THINK I CAN BEAT IT ONCE AND YES I DO THINK I'M PROBABLY END UP GETTING BREAST CANCER. I WAS LIKE OH MY BABY. LISTENING TO THOSE WORDS. MY DAUGHTER IS NOW 34, SHE IS BLESSED US WITH TWO GRANDCHILDREN, BRANDON IS SEVEN AND KEERA IS FIVE AND I KNOW FOR SURE THAT GOD DOES HAVE A SENSE OF HUMOR BECAUSE KERA WAS BORN WITH A THIRD NIPPLE AND I'M LIKE WHAT ARE DOING? WHY DO YOU DO THAT AND IT WAS RIGHT IN THE MIDDLE BETWEEN THE OTHER TWO. I DON'T WANT TO THINK ABOUT IF IT DEVELOPS WHAT HER BRACHYTHERAPY'S GOING TO LOOK LIKE--BRA'S LOOKS LIKE. MY DAD DIED A COUPLE WEEKS AGO WITH A VERY LONG BATTLE WITH METASTATIC CANCER. HE AND MY MOTHER MET WHEN THEY WERE 14, NO OTHER WOMAN'S LIPS HAVE KISSED MY LAYUPS, MY MOTHER SAID SHE STILL DIDN'T BELIEVE THAT NO THOUGH AND SO THEY DATED FOR FOUR YEARS, MARRIED AT 18. AND THEY WERE MARRIED ALMOST 68 YEARS WHEN DAD PASSED AWAY A FEW WEEKS AGO. HE SAID TO HER IN FRONT OF ME, I HOPE I DON'T HAVE TO WAIT TO ALONG FOR YOU TO JOIN ME. AND SHE SAID, YOU'RE GOING TO HAVE TO WAIT A WHILE HONEY BECAUSE I WANT TO BE HERE TO SEE BREAST CANCER CURED. I WANT TO BE HERE TO SEE THIS DISEASE PREVENTED AND I'D LIKE TO HAVE AT LEAST A YEAR AFTER THAT JUST TO ENJOY LIVING AND NOT WORRY ABOUT ALL OF THE PHONE CALLS I'M GETTING FROM FAMILIES OF PEOPLE SAYING MY DAUGHTER HAS JUST BEEN DIAGNOSED, MY DAUGHTER'S JUST BEEN DIAGNOSED, MY DAUGHTER HAS JUST DIED, WHY IS THIS HAPPENING? SO THAT WAS A PRETTY BIG WAKE UP CALL FOR ME BECAUSE I DIDN'T REALIZE THAT WAS ONE OF HER PERSONAL GOALS. AND I THOUGHT, WOW, WE DO NEED TO WORK HARDER AND SMARTER AND FASTER BECAUSE I WANT TO HAVE MY MOTHER NOT WORRY ANYMORE AND HAVE HER HAVE GOOD QUALITY OF LIFE ASK IN NOT WORRYING THAT THAT NEXT PHONE CALL WILL BE YET ANOTHER FAMILY SAY BEING OH MY GOD, MY LOVED ONE HAS CANCER. AND I'VE HAD THE OPPORTUNITY, BY THE WAY SHE'S 86, MY DAD HAD ALSO JUST TURNED 86, I HAD THE OPPORTUNITY A COUPLE YEARS AGO TO PARTICIPATE AS A PATIENT ADVOCATE IN A RESEARCH STUDY CALLED THE RAP STUDY, ANY OF YOU HEARD THAT? R. A. P.? RAPID AUTOPSY PROGRAM, DON'T YOU WANT TO SIGN UP FOR THAT? YEAH. THE PURPOSE OF THE STUDY WERE TO DO AUTOPSYS ON WOMEN THESE WOMEN WITHIN TWO HOURS AND WE WOULD HARVEST EVERY ORGAN OUTLET OF THEIR BODY AND TO SEE WHERE DID THE CANCER GO, WAS IT IN OTHER PLACES WE DIDN'T KNOW ABOUT AND WHAT CAN WE LEARN ABOUT THE BIOMARKERS AND PROGNOSTIC FACTORS BY DOING SO. AND AS A PATIENT ADVOCATE, I WAS BLESSED WITH THE CONCEPT LIKE WE DID ORGAN TRANSPLANTS. APPROACHING THE SPOUSE, MOTHER, FATHER WITHIN AN HOUR OR SO OF THIS PATIENT EXPIRING AND ASK THEM WOULD IT BE OKAY WITH YOU IF WE KEPT THE BODY FOR A COUPLE OF HOURS AFTER SHE'S GONE AND TOOK ALL OF HER ORGANS OUT. AND I SAID WE ARE NOT DOING THAT. ORGAN TRANSPLANT MEANS THE PERSON'S LIFE IS TURNOVERRING ON IN FIVE OR SIX OTHER PEOPLE THAT'S A GOOD THING. DISASSEMBLING THIS LOVED ONE, THAT'S NOT SOMETHING THAT A PARENT OR A HUSBAND OR A DAUGHTER IS GOING TOXIC EFFECTS EMBRACE. BUT I SAID, IF I EVER GET MATTA STATIC BREAST CANCER, I WOULD SIGN UP FOR THIS BECAUSE I KNOW THAT THEN MY DEATH WOULD NOT NUMBER VAIN AND THAT'S WHAT WE'RE GOING TO DO. WE'RE GOING TO ASK THE PATIENT, THEY LOOKED AT ME HORRIFIED. THE PEOPLE LIVING UNDER A MICROSCOPE TO BE HORRIFIED BECAUSE I WILL MAKE IT HARDER BECAUSE THE PATHOLOGY DOING THE AUTOPSIES HAS TO HEAR HER STORY AND I WANT THEM TO BOND AND A FACE AND PUT A STORY INTO THIS SITUATION. AND THE PATHOLOGY SAID I WENT INTO THIS BECAUSE I DIDN'T WANT TO TALK TO ANYBODY, AND I SAID WE'RE CHANGING THAT AND YOU WILL BE ONE OF THE BEST PATHOLOGISTS I'VE EVER KNOWN. ONE OF THE PATIENTS WE ASH APPROACHED WAS A 36 YEAR SURVIVOR, SHE WAS AN EXTRAORDINARY YOUNG WOMAN BRACA ONE POSITIVE AND HAD BRAIN [INDISCERNIBLE] FROM HER ORIGINAL DIAGNOSE WHEN SHE DEPRIVATION DEVELOPED DISTANT RECURRENCE AND HAD A SEIZEURE. SHE DID TELL HER LIFE STORE TOW MARK AND TO ME AND SHE SAID, YOU KNOW WE WERE TRYING TO CONCEIVE A BABY WHEN I HAD THAT SEIZURE AND THAT WAS JUST GOD'S WAY OF SAYING DON'T CONCEIVE BECAUSE SOMETHING ELSE IS HAPPENING WITHIN YOUR BODY. WASN'T THAT SMART FOR HIM TO HELP ME HAVE A SEIZURE SO WE COULD HAD THINGS OFF AT THE PASS, I THOUGHT WOW TO THINK IN AN OPTIMISTIC WAY ABOUT SUCH A THING. AND SHE SAID, I DO HOPE THAT AT ONE POINT IN TIME, ROB, MY HUSBAND, WILL MARRY AGAIN AND HAVE A BABY. I THINK HE WILL MAKE AN AMAZING DAD AND I SAID MARK IS A DAD, HE JUST BECAME A DADDY TWO WEEKS AGO AND MARK WAS LIKE, DON'T TALK ABOUT IT TO ME AND SHE SAID LET ME SEE A PICTURE. HE FROZE. I SAID HAVE YOU A CELL PHONE, HAVE YOU A PATIENTS IN THE CLINIC OUR THIS THERE. HE VERY HESITANTLY TOOK THE PHONE OUT AND SHOWED HER THE PICTURE AND SHE SAID HE LOOKS WONDERFUL. WHAT IS HIS NAME. HE SAID HIS NAME IS DAVID. SHE SAID OH MY HEAVENS, I KNOW HE'S GOING TO BRING YOU SUCH JOY. I COULD SY BY YOUR FACE HE ALREADY HAS. AND MARK STARTED CRYING. THIS WOMAN WHO DIED THREE WEEKS LATER TOOK HIS HAND AND SAID MARK IT'S OKAY, IT'S ALL RIGHT. AND I THOUGHT I AM WITNESSING A WOMAN WHO IS GOING TO BE DEAD IN LESS THAN A MONTH COME FORT BEING THE PATHOLOGIST WHO'S GOING TO DO AN AUTOPSIES ON HER. THIS IS PROFOUND. AND SHE SAID I HOPE YOU ESPECIALLY LEARNED IMPORTANT THINGS FROM MY ORGANS SINCE I'M BRACA ONE POSITIVE. MY DEATH WILL NOT BE IN VEIN BECAUSE OF THE RESEARCH YOU WILL DO. HE DID TELL ME WHEN HE DID HER AUTOPSIES, HE HAD TO COVER HER HANDS WITH SURGICAL TOWELS BECAUSE HE SAID I REMEMBERED HER REACHING OVER AND HOLDING MY HAND. AND MARK IS A FANTASTIC PATHOLOGIST. ABSOLUTELY FANTASTIC. AND THOUGH I CERTAINLY APPEAR IN SURVIVOR STATISTICS OR ON CHARTS AND SUCH, I DID END UP WITH, IT WAS THE GIFT THAT KEEPS ON GIVING, I HAVE CARDIAC COMPLICATIONS, LUNG COMPLICATIONS AND OTHER THINGS. I'M THANKFUL TO SURSLIVED ALL OF IT BUT IT WAS NOT WITHOUT PAYING A PRICE. I WANT TO HAVE YOU MEET WOMEN FOR THE NEXT COUPLE OF MINUTES THAT PARTICIPATED IN A RETREAT THAT I ORGANIZED AT JOHNS HOPKINS, IT'S HELD OFFSITE AND YOU'LL SEE WHAT THAT'S ALL ABOUT; I WANT TO YOU MEET THESE WOMEN AND RECOGNIZE FIRST OF ALL THAT EVERY SINGLE ONE OF THEM IS DEAD AND WAS DEAD JUST MONTHS AFTER THIS PARTICULAR VIDEO WAS DONE. I MAY NEED YOU TO COME UP AND PUSH THAT BUTTON. [* MUSIC ] >> THERE'S INTERESTING HISTORY REGARDING THIS PARTICULAR RETREAT THAT WE REFER TO AS THE METASTATIC COUPLES RETREAT. FOR MORE THAN A DECADE I'VE BEEN CONDUCTING SURVIVOR RETREATS FOR WOMEN DAY ZERO-THREE AND WE'VE BEEN HOLDING THEM HERE AT THIS FACILITY A SPIRITUAL CENTER, A VERY RELAXING ENVIRONMENT, PIECEFUL ENVIRONMENT BUT I WOULD GET E-MAILS FROM WOMEN SOME I KNEW, SOME I DID NOT SAYING WHEN IS THE RETREAT FOR ME, I HAVE MET STATIC DISEASE. WHEN I THROW MY PITY PARTY AT THE BEGINNING AND I HAD THE MOMENT OF WHY IS THIS HAPPENING TO ME, WHY DOES THIS HAPPEN TO ME, AM I YOUNG, I HAVE TWO YOUNG KIDS WHY AM I GOING THROUGH THIS AND HIS RESPONSE IS, IT'S NOT HAPPENING TO YOU, IT'S HAPPENING TO US. >> ONE OF THE BIGGIST THINGS THEY'RE WORRYING ABOUT AS THEY CONTINUE TO TRAVEL FORWARD, RECOGNIZING THAT EVENTUALLY THEY WILL DIE OF THIS DISEASE. >> I THINK I WAS IN DENIAL THAT IT CAN'T JUST BE CURED AND BE OVERWITH. AND I KNOW IT'S A LONG ROAD AHEAD. >> I THINK THAT'S BOTH OUR BEST WAY OF COPING WITH THINGS IS THROUGH HUMOR WHICH REALLY THROWS THE DOCTORS OFF AND THE NURSES AND OUR FRIENDS, YOU KNOW, BECAUSE A LOT OF THEM SAY THE SAME THING YOU'RE ALWAYS HAPPY, YOU'RE ALWAYS SMILING, EVERYTHING'S GREAT, YOU KNOW, EVEN THOUGH YOU JUST SHAVED YOUR HEAD. >> SOME OF THE ACTIVITIES WE PROVIDE FOR THESE COUPLES IS AN OPPORTUNITY FOR THEM TO SPEAK WITH OTHERS IN THE SAME SITUATION THEY VSO WE BREAK THE COUPLES APART AND WE WILL HAVE WOMEN ONLY IN ONE ROOM, MEN ONLY IN ANOTHER ROOM, I THINK THAT THE MEN ONLY IS ONE OF THE MOST POWERFUL THINGS THAT WE DO AT THIS EVENT. MEN ARE THIRSTY TO FIND OTHER MEN IN THE SAME SITUATION. THERE IS A SENSE OF RELIEF WHEN THEY HEAR A HUSBAND SAY THIS IS HOW I'VE BEEN DEALING WITH THIS, I GET IN MY CAR AND I SCREAM AND CRY AND CURSE. AND TO FIND OUT THAT ALL OF THEM GET IN THEIR CAR AND SCREAM AND CRY AND CURSE. THAT THEY'RE NOT ALONE. >> YOU NEVER DO FULLY RECOVER. THERE'S ALWAYS NOTHING ELSE AND THEY COME AT A FASTER PACE. SO AS TIME GOES ON, IT'S TAKING AWAY ANOTHER CHUNK OF THE LIFE YOU HAD TOGETHER AND WHAT YOUR WIFE USED TO BE ABLE ... >> WE DO SPEAK UP AND SHARE. >> WE TALK INDEED OUR GROUP ABOUT THE LOSS OF HAIR BEING YOU KNOW SOMETHING THAT PEOPLE LOSE THEIR PUBLIC FAITH, BUT I'VE LOST MY PUBLIC FAITH AND BODY AND WHO IS THAT PERSON? I DON'T RECOGNIZE HER. >> WELL I KNOW IT'S INEVITABLE BUT, IT'S HARD TO BELIEVE THAT I ACTUALLY HAVE IT IN MY BONES RIGHT NOW BECAUSE I FEEL SO GOOD. >> RIGHT NOW I FEEL LIKE I'M RESPONDING TO TREATMENT SO WELL THAT IT'S ALMOST MIRACULOUS. >> I DON'T WANT THEM TO FEEL LIKE I GAVE UP. YOU KNOW WHAT I'M SAYING, I WANT THEM TO ALWAYS THINK THAT NO NO MATTER WHAT, I FOUGHT FOR THEM. YOU KNOW? >> I WOULD SAY THAT MY BIGGEST FEAR IS FOR MY HUSBAND BECAUSE YOU KNOW AT THE END OF IT ALL, I'LL BE DEAD. THAT'LL BE EASY, IT'S LIKE GOING TO SLEEP, I GUESS, I DON'T KNOW. >> WE HAVE PROVIDED INFORMATION ABOUT HOW DECISIONS ARE MADE AND THAT PHYSICIANS ARE NOT GOOD BUT ALSO THAT PHYSICIANS ARE HESITANT TO SPEAK UP AND REALLY GIVE A TIME FRAME EVEN WHEN IN SOME CASES THEY DO KNOW THE TIME FRAME JUST AS I MENTIONED I CAN SEE HOW ILL SOME OF THESE WOMEN ARE AND I CAN GUESSTIMATE HOW MUCH LONGER THEY'RE GOING TO BE HERE. >> I AM BEDRIDDEN FOR MOST OF THE DAY BECAUSE OF MY PAIN AND BECAUSE OF A GREAT DEAL OF FATIGUE AND I DON'T KNOW HOW CLOSE I AM TO THE END. >> IT'S HARD TO FACE YOUR OWN MORTALITY. >> THE HARDEST PART FOR ME, I THINK IS PROBABLY THE KIDS. I HAVE A TWO YEAR-OLD AND A THREE YEAR-OLD, THEY'RE ONE AND TWO WHEN I FIRST GOT DIAGNOSED AND JUST NOT KNOW FIGURE I'M GOING TO BE AROUND TO SEE THEM GROW UP, NOT KNOWING IF I WILL BE AROUND TO SEE THEM IN KINDERGARTEN, YOU KNOW? NOT KNOWING IF THEY'RE GOING TO REMEMBER WHO THEIR MOM IS AT THE END OF ALL OF THIS. THAT TO ME IS HARD. YOU KNOW? I JUST, I DON'T WANT THEM TO FORGET ME. >> ONE OF THE THINGS WE DID IN THE WOMEN'S ONLY GROUP, WAS THAT I TALKED ABOUT1‡3 CONSIDERING GETTING CARDS FOR THEIR CHILDREN, GOING TO THE STORE, ASKING THE STORE MANAGER OF THEIR CARD STORE AND SAY, I'M GOING TO SUCCUMB TO THIS DISEASE AND I NEED YOUR HELP. I WANT TO SELECT BIRTHDAY CARDS FOR MY CHILDREN UP THROUGH AGE USUALLY 21 WHEN MY CHILD GOES TO COMMUNION FOR THE FIRST TIME, I WANT TO I HAVE CARD FOR THAT. WHEN THEY GET MARRIED, WHEN THEY HAVE THEIR FIRST CHILD, AND WRITING IN THOSE CARDS, WHAT DO YOU WANT TO TELL YOUR CHILD ON THAT DAY, IS A VERY POWERFUL WAY, TO STILL BE HERE IN FILLING YOUR VALUES AND YOUR CHILDREN; WE ALSO HAVE SOME OTHER SESSIONS LOOKING AT SOME PRIVATE MOMENTS HAVING A MASSAGE, HAVING BRACI THERAPY. WE PLAY THE ALMOST NEWLY WED GAME WHICH IS A LOT OF FUN. WE'RE ALSO GOING TO BE OUT ON THE LABYRINTH TODAY WHICH IS A BEAUTIFUL STONE LABYRINTH HERE, ONE OF THE INTERESTING THING WHEN IS WE DO THIS FOR COUPLES IS WE SEND THE WIVES IN FIRST AND THEN WAIT A FEW MINUTES AND THEN SEND THE HUSBANDS IN AND AT SOME POINT ON THE PATH, AND IT'S A VERY SPECIFIC WALKING PATH THAT YOU DO, THE HUSBAND AND WIFE WILL MEET. AND HOW THEY INTERACT WITH ONE ANOTHER, WHETHER THEY JUST BRUSH BY OR WHETHER THEY STOP AND HOLD ONE ANOTHER, WHETHER THEY STOP AND SOB WITH ONE ANOTHER. TO ME IS A VERY STRONG SYMBOLIZATION OF THEIR LOVE FOR ONE ANOTHER. WE ALSO WILL HAVE THIS AFTERNOON, THE CREATION OF MEMORYSHIPS AND WHAT THIS ENTAIL SYSTEM, EACH OF THE PATIENTS WILL BE GIVEN A VASE IN THE SHAPE OF A HURRICANE LAMP AND IT HAS BLUE AND GREEN SEA GLASS ALL OVER THE OUTSIDE, THE VASE IS WHITE WITH SAND AND EMBED INTOED THAT SAND ARE SEA SHELLS. THEY WILL BE GIVEN A JOURNAL, A PINK JOURNAL AND STONES, PEBBLES, SMALLER ROCKS, SEA SHELLS AND SEA GLASS FOR THEM TO USE TODAY AS WELL AS TO TAKE HOME A SUPPLY OF. AND I WILL ASK EACH OF THEM TO GO BACK IN TIME AS FAR AS BACK AS THEY CAN REMEMBER WHAT WAS THEIR FIRST HAPPY MEMORY. I WANT THEM TO RECORD THAT IN THE JOURNAL AND THEN SELECT ONE OF THESE OBJECTS TO THEN GO IN THIS VASE WHICH I TELL THEM REPRESENTS THEM. THIS VESSEL IS A SYMBOLIZATION OF THEM AND THEIR LIVES. OUR MEMORIES ARE SOMETHING WE HOLD ON TO, WE TAKE THEM WITH US, WE ALSO LEAVE THEM BEHIND AND IT'S A POWERFUL CONNECTION. >> IT'S NICE TO HAVE PEOPLE THAT GET IT. YOU KNOW? THEY BED WHAT--UNDERSTAND WHAT YOU'RE GOING THROUGH. THEY UNDERSTAND--IF IT'S NOT THE EXACT SAME STAGE OR DISEASE. >> IT MAKES ME HAPPY TO BE ABLE TO TALK ABOUT THIS BECAUSE IT'S SO WONDERFUL THAT THIS IS OFFERED TO PEOPLE GOING THROUGH THINGS LIKE THIS. I MEAN I--I WISH IT WAS MORE, MORE SPREAD AND CLOSER TO HOME AND ALL THAT OTHER STUFF, BUT IT'LL SPREAD, YOU KNOW FROM ALL OF US. >> I'LL BE TALKING TO THEM ABOUT THE FACT THAT THEY'VE ALL BEEN IN SHARK INFESTED WATERS. TGEY COME TO JOHNS HOPKINS OR THEIR CANCER STRAY JECTORY WHICH IS A SAFE HARBOR SO WE GET THEM STABILIZED SO THEY CAN SET OUT TO MORE PORTS OF CALL BUT ONE DAY THEY WILL DO A FINAL SAIL THEY MUST DO ALONE. I WILL THEN GIVE THEM ON PARCHMENT PAPER A VERSE WRITTEN BY HENRY VAN DYKE. I PARAPHRASE THAT VERSE FOR THEM AND THE VERSE GOES LIKE: HE TALKED ABOUT A FAMILY STANDING HERE ON THIS SHORE, AND THEY'RE AT A DOCK AND THEY SEE THIS HUGE MAGNIFICENT WHITESHIP IN A DOCK AND THEY'RE WATCHING AS THEIR CARGO IS LOADED ON AND THEY'RE REALLY ADMIRING HER SIZE AND HER GRACE, CARGO IS DONE. THE SAILS GO UP, THE WIND SNAPS THE SAILS AND SHE SETS OUT OF THE PORT OUT INTO THE OCEAN AND THEY ADMIRE HER EVEN MORE IN SEEING HER NOW SO GRACEFUL AS SHE GOES OUT FURTHER AND FURTHER OUT INTO THE WATER AND THEY WATCH HER AS SHE'S GOING OUT TO THE HORIZON LINE AND SHE GETS SMALLER AND SMALLER AND SMALLER UNTIL THEN WHEN SOMEONE SAYS, SHE'S GONE BUT GONE WHERE? SHE'S ONLY GONE FROM OUR SIGHT SHE'S JUST ... JUST AS ABLE TO CARRY HER LIVING FREIGHT TO HER NEW AND FINAL DESTINATION. HER SIZE IS DIMINISHED IN US, BUT NOT IN HER, AS WE STAND HERE AS FAMILY AND FRIENDS AND SAY, THERE SHE'S GONE, THERE'S FAMILY AND FRIENDS ON THE OTHER SHORE STANDING UP AND SAYING LOOK HERE SHE COMES. IT'S A VERY POWERFUL WAY TO DISCUSS DEATH AND TO SEE DEATH IN A MORE PEACEFUL MANNER, EVERY SINGLE HUSBAND WHO HAS ATTENDED THESE RETREATS HAS USED THAT ANALOGY AND WILL SAY WE FOUND OUT TODAY THAT CANCER--WE FOUND OUT SHE'S GETTING CLOSE TO THE HORIZON LINE AND THEN THEY WILL CALL ME AGAIN AND SAY, SHE'S REACHED THE OTHER SHORE AND WHAT TIME AND WHO HE BELIEVES WAS THERE WAITING FOR HER. >> WE HAVE A PREVENTION, TRUE VENTION FOR THIS DISEASE, I WANT TO MAKE SURE THESE WOMEN ARE NOT FORGOTTEN SURVIVORS. >> SO, YOU HAVE YOUR WORK CUT OUT FOR YOU, I BELIEVE. ON BEHALF OF THE WOMEN THAT YOU'VE JUST SEEN IN THIS VIDEO AND ALL OF THEM ARE GONE. I'VE BEEN DOING THESE NOW FOR SIX YEARS. BETWEEN ONE MONTH AND SIX MONTH SYSTEM THE AVERAGE LENGTH OF TIME THESE WOMEN HAVE SURVIVED AFTER THESE RETREATS. SO ON BEHALF OF THEM, ON BEHALF OF MY MOTHER, MY 86 YEAR-OLD MOTHER, ON BEHALF OF THE 200 PEOPLE E-MAIL ME A DAY THAT I DON'T KNOW WHO HAVE JUST FOUND OUT THEY'VE BEEN DIAGNOSED WITH BREAST CANCER AND ARE PETRIFIED, ON BEHALF OF MY DAUGHTER WHO IS 34 CHOUGH HAS BEEN GETTING BREAST IMAGING DONE SINCE THE AGE OF 28 AND ON BEHALF OF MY LITTLE KEERA WHO IS FIVE YEARS OLD WHO CAN'T WAIT TO BE OLD ENOUGH TO WEAR A BRA, I ASK YOU TO WORK AS HARD AS YOU CAN, AS SMART AS YOU CAN. YOU HEARD EARLIER ABOUT DRAWING OUTSIDE OF THE LINES. I WANT YOU TO THINK OUT OF THE BOX AND IN THIS CASE, OUT OF THE BRA IN ORDER TO FIGURE OUT WHAT DO WE NEED TO DO SO THAT ONE DAY, HOPEFULLY NOT TOO FAR FROM NOW. MY GRANDDAUGHTER WILL BE ABLE TO SAY TO OTHER PEOPLE, MY MOM MOM HAD BREAST CANCER TWICE, LONG BEFORE I WAS EVER DONE. MY MOMMY WORRY BODY GETTING BREAST CANCER AND SHE'S HAD LOTS AND LOTS OF X-RAYS DONE TO CHECK THAT MAKE SURE HE WAS OKAY, BUT I DON'T HAVE TO WORRY ABOUT IT BECAUSE THEY FIGURED OUT A WAY TO PREVENT IT. AND I HAVE RECEIVE THAD PREVENTION AND BOY AM I GLAD. THANK YOU. [ APPLAUSE ] >> THANK YOU LILLY FOR THAT INCREDIBLE STORY AND FOR PUTTING A FACE TO WHAT WE'RE TRYING TO DO HERE. OKAY SO I WOULD LIKE TO NOW MOVE ON TO THE REST OF THE CEREMONY AND OUR NEXT SECTION IS GOING TO HAVE OUR INVENTORS COME FORWARD AND BRIEFLY, VERY BRIEFLY DESCRIBE THEIR INVENTIONS. I KNOW YOU PROBABLY THOUGHT YOU WOULDN'T HAVE MORE TIME BUT WE ARE RUNNING SHORTOT CEREMONY SOY I WOULD LIKE TO YOU COME FORWARD AND HIT THE HIGHLIGHTS OF YOUR INVENTION, I WILL NAME YOU, AT A TIME HERE AND YOU CAN COME FORWARD ONE RIGHT AFTER THE OTHER. >> FOR US WE HAVE FIRST OF ALL I WANT TO MENTION THAT THERE ARE THREE SCIENTISTS WHO COULD NOT BE WITH US TODAY, THREE INVENTORS THAT'S TOM, DENNIS AND ELEN. AND THE ONE WHO IS ARE HERE ARE KAREN BERG, CLEMSON UNIVERSITY, MITCHELL HOGUE, NCI, MADDIA, WITH NCI, STANIS, FROM NCI'S FED RICK NATIONAL LABORATORY FOR CANCER RESEARCH, STEVEN, AT ALBERT EINSTEIN COLLEGE OF MEDICINE AND FORMERLY AT NCI, STEVEN YOU HADIT NCI AND SHAREY, FROM--SHERRY NCI. >> WOULD YOU LIKE TO START US OFF. >> HI, I AM KAREN BERG AND I SERVE AS DIRECTOR OF INSTITUTE FOR BIOLOGICAL FACES OF ENGINEERING AND FACULTY MEMBER, GOING SHORT IS AGAINST EVERYTHING I EARNED. THE CLEMSON UNIVERSITY INVENTION IS IN SHORT AN INJECTABLE BREAST TISSUE OPTION. SO WHAT THIS MEANS IS A MIX TOUR OF CELLS, NORMAL HEALTHY CELLS THAT ARE TAKEN FROM THE PATIENT THAT ARE COMBINED WITH DEGRADABLE BEADS AND COMBINED WITH A DEGRADABLE GEL AND THE GEL FACILITATES DELIVERY IN A MIN MEDICARE AND MEDICAIDLY INVEIGHSIVE FASHION AND THE BEADS FACILITATE THE FORM AND STRUCTURE OF THE DEVELOPING TISSUE AND GID THE CELLS TO GROW. THE MATERIALS COMPONENTS THE GEL AND THE BEADS ARE DEGRADABLE, THE IDEA IS THAT THEY LOSE THEIR NEED IN THE BODY, SLOWLY DISAPPEAR AND ARE REMOVE FRIDAY THE BODY SO THAT THERE'S NO LONG-TERM IMPLICATION OF THOSE MATERIALS. SO IT'S DIFFERENT AND UNIQUE BECAUSE IT ADDRESSES TWO PROBLEMS. ONE IS RECONSTRUCTION AND THE OTHER IS PREVENTION OF METASTASIS AS WELL AS RECURRENCE BECAUSE THE BEADS ACTUALLY HAVE AN ANTICANCER PROPERTY TO THEM. THAT'S BEEN DESIGNED AND BUILT INTO THE SYSTEM. AS THE BEADS DEGRADE THIS BECOMES MORE PRONOUNCED AND DESIGNED TO DEGRADE IN PARTICULAR TIME FRAME. SO IT'S ALSO UNIQUE IN THAT IT'S A PLATFORM TECHNOLOGY SO, THE COMPONENTS AND MIXTURE AND THE MIXTURE CAN BE CHANGED. THE RELATIVE WEIGHTING OF THE SYSTEMS, THERE CAN BE MORE BEADS, LESS BEADS, MORE CELLS, CELLS, DIFFERENT CHEMRIES AND SO FORTH IS THE INTENT WAS TO PERSONALIZE THE SYSTEM BECAUSE THERE IS NO ONE-SIZE-FITS-ALL SOLUTION. SO IN SHORT THAT'S THE INVENTION, I WOULD LIKE TO THANK MANY INDIVIDUALS MUCH INPUT FROM BREAST CANCER SURVIVORS MY MENTOR WHO ORIGINATED DISCUSSION WITH ME ON THIS PROJECT. WHO WAS THE CHIEF OF CERVICAL CONICOLOGY AT CAROLINE'S' MEDICAL CENTER, DR. WALTER HOLDER WHO HAS A FANTASTIC BREAST CANCER BIOLOGIST WHO IS HERE TODAY DR. BOOTH, MANY GRADUATE STUDENTS AND MANY UNDER GRADUATES HAVE CONTRIBUTED TO DIFFERENT FACETS OF THE PROJECT. DO I WANT TO THANK THE ORGANIZERS AS A TREMENDOUS OPPORTUNITY TO BE HERE. THE AVON FOUNDATION FOR WOMEN FOR FUNDING THE WORK, TAKING A LEAP OF FAITH AND FUNDING THE WORK AND THANK YOU TO THE ENTHUSIASTIC TEAM MEMBERS, I DID NOT GO INTO A FACULTY CAREER TO DEVELOP IDEAS THAT SIT ON SHELVES AND YOU ARE THE ONES THAT MOVE THOSE IDEAS AND AN IDEA IS THAT, AN IDEA ON A SHELVE. SO A BIG THANK TO YOU WELL. [ APPLAUSE ] >> OKAY, FIRST OF ALL I WOULD LIKE TO TAKE THIS OPPORTUNITY TO THANK NCI TECHNOLOGY TRANSFER, TOM AND CENTER FOR INNOVATING AND FOR REALLY EXCELLENT JOB ORGANIZING THIS COMPETITION AND I ALSO WANT TO, I THINK I WANT TO THANK ALSO ROSE, WHERE'S ROSE, I THINK TBRE WENTLY GOT E-MAIL FROM YOU AT MIDNIGHT. I THINK. YOU PROBABLY DON'T SLEEP AS MUCH AS ROSEMARIE. SO ALSO I WANT TO THANK MY TECHNIQUE TRANSFER OFFICE, LORI, I DON'T KNOW IF SHE IS HERE AND I SAW DAVE YOUNG IS HERE AND HE'S [INDISCERNIBLE] LORI I ALSO THANK DAVID [INDISCERNIBLE] HE'S THE NCI TECHNOLOGY TRANSFER OFFICE. SO ALL OF YOU WORKING WITH US TO TRY TO MAKE OUR BENCH LABORATORY DISCOVERY AVAILABLE FOR COMMERCIALIZATIONS AND POTENTIAL USE FOR CLINICAL APPLICATIONS. SO I LEAD THERAPEUTIC ABET BODY DISCOVERY GROUP AT NATIONAL CANNER ENSITUTE IN BETHESDA CAMPUS AND RESEARCH IN MY LAB AND WE TRY TO DISCOVER THE BIOLOGY--BIOLOGY OF THE CANCER DRIVEN BY THE EXTRA CELLULAR MOLECULES LIKE ANCHOR PROTEIN OR [INDISCERNIBLE] PROTEOGLYCANS SUCH AS [INDISCERNIBLE] IN THIS CASE AND DEVELOP ANTIBODY FOR NOVEL CANCER THERAPY. SO< FOR THIS CHALLENGE IS THE RELEVANT TO THE NEW ANTIBODY WE DEVELOPED [INDISCERNIBLE] SO IT'S A CELL SURFACE MOLECULE OVEREXPRESSING MULTIPLE TYPES OF TUMORS. WE CONSIDER IT AS NCI GENE BECAUSE IT WAS ORIGINALLY DISCOVERED BY [INDISCERNIBLE] AND MIKE WEEDER HANS, IN EARLY 1990S. ANDA THAT TIME THE EARLY EVIDENCE SHOWING [INDISCERNIBLE] IS A VERY GOOD TARGET FOR MESOTHELIOMA AND OVARIAN CANCER. BASED ON THESE ISSUES AND THE DOCTOR DEVELOPED THE IMMUNOTOXIN AGAINST THE [INDISCERNIBLE] AND OUR ONCOLOGIST IS RUNNING A PHASE ONE CLINICAL TRIAL USING THIS IMMUNOTOXIN FOR THE TREATMENT OF MESOTHELIOMA AND OVARIANCE CANCERS. SO AROUND 2012 OUR COLLABORATOR GENE, [INDISCERNIBLE] AND THE COLLEAGUES, DEVELOPED THE [INDISCERNIBLE] AND COULD BE THE TARGET FOR SHEER BREAST CANCER AND TRIPLE NEGATIVE BREAST CANCER SO THIS IS IMPORTANT DISCOVERY BECAUSE AS WE KNOW BREAST CANCER HAS PATIENTS HAVE BEEN FITTED FROM THE TREATMENT EVER THE HERCEPTIN AND METRICS TEWS MACK TREATMENT, BUT PER BREAST CANCER WE CHOOSE [INDISCERNIBLE] AND ESTLO GEN RECEPTOR NEGATIVE AND THE [INDISCERNIBLE] JUST DON'T WORK VERY WELL. THOSE PATIENTS ARE NOT RESPONSE TO THOSE PATIENT THERAPIES. THIS PARTICULAR [INDISCERNIBLE] SO IF THAT IS TRUE AND IT COULD BE A POTENTIAL TARGET FOR TRIPLE NEGATIVE BREAST CANCER WILL BE A VERY GOOD TARGET OF BREAST CANCER SO THIS CHALLENGE COMES AT THE RIGHT TIME BECAUSE WE'RE JUST THINKING ABOUT MAYBE WE SHOULD DEVELOP ANTIBODY THERAPY FOR BREAST CANCERS. AND THE INVENTION IN THIS TECHNOLOGY IS SO CALLED SINGLE DOMAIN SO WE DO THIS BY COLLABORATION WITH A GROUP OF GRADUATES, AND IMAGE GROUP, AND THE IMAGE GROUP DEVELOPED HUMAN [INDISCERNIBLE] ONLY SINGLE ANTIBODY LIGAND AND WE USE THIS I LIGAND TO SELECT A NEW ANTIBODY CALLED SPONE O WA'S THE UNIQUE THISNESS OF THIS ANTIBODY IT BINDS TO A SITE TO MAYBE NOT BE ACCESSIBLE BY COMBINATION ANTIBODY BECAUSE IT'S TOO BIG. SO, THE ANTIBODY ACTUALLY BIND TO THE SITE, FOR THE TUMOR CELL SURFACE, BECAUSE OF THIS IT HAS COMPLEMENT DEPENDENT CYTOTOXICITY IN ADDITION TO ANTIBODY DEPENDENT TOXICITY AND [INDISCERNIBLE] ANYBODY MAY HAVE. SO WE THOUGHT THIS WAS GOOD CANDIDATE FOR DIAGNOSE AND I GUESS THERAPEUTIC VALUES AND I'M GLAD, I THINK I WAS TOLD 17, SIX-SEVEN TEAMS IN TECHNOLOGY IN THIS CHALLENGE, COMPETING RIGOROUSLY FOR THIS AND I WANT TO TAKE THIS OPPORTUNITY TO CONGRATULATE YOU THAT THE WINNING TEAM, THE STANDIFORD GROUP AND OBVIOUSLY YOU GUYS DID THE VERY GOOD JOB AND DID A GOOD JOB ON THIS AND WISH YOU THE BEST LUCK AND THANK YOU VERY MUCH. [ APPLAUSE ] >> GOOD AFTERNOON I AM NADIA AND I AM HEAD OF SYNTHETIC BIOLOGICS AND DRUG SOEVER DISCOVERY OF THE NCI. OUR SMALL GROUP IS VEERS ABOUT FINDING CURES FOR CANCER BUT AS YOU KNOW IT'S A VERY CHALLENGING FIELD. SO MOST OF THE EFFORTS IN THE DRUG DISCOVERY HAVE BEEN DEVOTED TO FINDING WHAT'S CALLED MOLECULAR TARGETED DRUGS AND ABOUT 10 YEARS AGO, WITH THE SUCCESS OF GLEEVEC WE HOPE THAD IF WE DEVELOP MOLECULES THAT CAN COMPENSATE FOR PATIENTS THAT ARE FOUND IN THIS PARTICULAR TUMOR, WE CAN DEVELOP CURES. SO CALLED PERSONALIZED THERAPY AND PAPPYS. AND MANY OF THEM HAVE BEEN SUCCESSFULLY DEVELOPED RECENTLY. HOWEVER, WHAT WE HAVE HOPED FOR DID NOT HAPPEN. SO THOSE COMPOUND DOS WORK, THEY DO SHRINK TUMORS BUT TUMORS INEVITABLY REGROW AND FREQUENTLY MORE AGGRESSIVE AT TIMES. SO THE VERY ACTIVE GENOMIC STATUS HAVE HELPED US TO UNDERSTAND WHY IT HAPPENS AND THE MAJOR REASON IS TUMOR HETEROGENEITY WHICH MEANS TUMORS MUTATE WHILE THEY GROW AND THEY'RE COMPOSE FRIDAY CELLS THAT CARRY DIFFERENT SO-CALLED DRIVER MUTATIONS SO IF YOU GIVE A DRUG THAT COMPENSATES FOR ONE MUTATION, YOU ELIMINATE CELLS THAT ARE DEPENDENT ON THEM. HOWEVER THERE ARE MULTIPLE OTHER CLONES FOR NEW TUMORS. SO, ONE OF THE APPROACHES THAT ARE TRYING TO USE IS USING GENERAL TOXINS, AND THEY HAVE BEEN SUCCESSFUL AND POPULAR FOR QUITE SOMETIME, THEY ARE BETTER IN SOME SENSES BECAUSE THEY WORK ON EVERY FAST GROWING CELL, SO THAT MEANS THEY CAN BUILD ON DIFFERENT SUBTUMOR OF CELLS, HOWEVER WE ULTIMATELY KNOW HOW TOXIC THEY ARE AND IT'S NOT ONLY THAT THEY HARM THE PATIENT BUT THEY ARE ALSO NOT VERY EFFECTIVE BECAUSE WE HAVE [INDISCERNIBLE] TO THE PATIENT. BUT ONE OF THE APPROACH SYSTEM FREQUENTLY VERY SUCCESSFUL TO OVERCOME THIS IS SELECTIVE DELIVERY OF THOSE MOLECULES TO TUMORS AND THAT'S WHAT OUR OUR CHALLENGE IS ABOUT. THIS IS A NOVEL TYPE OF TOXIN THAT CAN BE EASILY ATTACHED TO KNOWN CARRIER OR DELIVERY [INDISCERNIBLE]. AND THE NEW PROPERTY OF THIS ONE IS NEWLY MOLECULAR MECHANISM BUT ALSO VERY IMPORTANT THAT EASILY TRAVELS FROM ONE CELL TO ANOTHER. WHICH MEAN FIST IT'S DELIVERED TO THE TUMOR IT WILL HELP [INDISCERNIBLE]. HOWEVER MY GROUP HAS MANY PROJECTS AS OUR TECHNOLOGY TRANSFER OFFICE KNOWS AND THEY ALL LOOK PROMISING TO ME, BUT WE WON'T BE ABLE TO DEVELOP ANYTHING WITH THE HELP OF INDUSTRIAL COMPONENT THAT'S WHY I THINK THAT THIS CHALLENGE IS TERRIFIC AND I THINK IT'S GOING TO HELP AND I'M SURE IT WILL BE SUCCESSFUL AND THEY HAVE TO COMPLEMENT OTHER PEOPLE WHO DETERMINE THIS AMOUNT OF YOUR [INDISCERNIBLE] SUCCESS OF THIS THING. AND THANK YOU SO MUCH. [ APPLAUSE ] >> HI, I AM PATRICK AND I AM TRAINED MOLECULAR BIOLOGIST AND CANCER CELL BIOLOGIST. I AM MEMBER OF ADVANCED TECHNOLOGY TREMENDOUS AND I AM ALSO INVENTOR OF PARTICLE FORS CANCER TREATMENT. MY COLLEAGUE DR. DAVE [INDISCERNIBLE] IS CO DEVELOPING THE TECHNOLOGY SO FIRST OF ALL I WOULD LIKE TO DESCRIBE OUR CONCEPT OF TREATMENT OF CANCER. A CONVENTIONAL TREATMENT WOULD INVOLVE PRIMARY SURGERY, THEN CHEMO THERAPY AND RADIO THERAPY EFFECTIVELY SUCCESSFUL BUT IN SOME CASES IF YOU THOUGHT IT'S NOT ENOUGH, PATIENT COMING BACK WITH METASTATIC TUMORS, SO I'VE EXPERIENCED THOSE TWO DIFFERENT FIELDS, I DECIDE TO GENERATE PARTICLES WHICH I WILL BE [INDISCERNIBLE] FOR DELIVERING THERAPEUTIC PROTEINS INTO CANCER CELL IN VIVO, SURELY INJECTING THEM INTO PRIMARY TUMOR. OBJECTIVE IS TO CONVERT CANCER CELLS AS PRIMARY TUMOR BECOMING AS CANCER VACCINE, CANCER ITSELF, I EXPRESSING MARKERS WHICH ARE SPECIALLY FOR CANCER BEHAVIOR SO WHAT WE NEED, WE NEED SOME LITTLE TRIG TORE PRESENT THOSE MARKERS TO PATIENT IMMUNE SYSTEM SO THEN STRONG IMMUNE SYSTEM RESPONSE WILL ELAMEINATE ANY METASTATIC OUTGROWTH. SO WE HAVE [INDISCERNIBLE] RESULTS IN OUR ANIMAL STUDIES USING CELL LINE, WHAT IS [INDISCERNIBLE] TO HUMAN BREAST CANCER STAGE FOUR, METASTATIC AND TO OUR PRELIMINARY FROM IN VIVO [INDISCERNIBLE] ARE QUITE, QUITE SATISFACTORY AT THIS STAGE. OF COURSE [INDISCERNIBLE] MORE EXPERIMENT TO FINE TUNE OUR TECHNOLOGY AND WE HAVE VALUE COLLABORATORS IN IN PROJECT. THOSE INCLUDE DOCTOR PHILLIP ANTONIO, FROM [INDISCERNIBLE] BIOMEDICAL RESEARCH INCORPORATED AND SHE'S OUR ANIMAL STUDY COORDINATOR. DR. HOWARD YOUNG IS FROM NATIONAL CANCER INSTITUTE AND HE'S FROM [INDISCERNIBLE] EXPERIMENT AND E-MAIL [INDISCERNIBLE]. IS A PAST MEMBER OF OUR LAB. SHE WAS INVOLVED IN PLASMID PREPARATION FOR NEUROSTATTIC. ADDITIONALLY I AM VERY GRATEFUL TO NATIONAL CANCER INSTITUTE AND BIOMEDICAL RESEARCH INCORPORATED FOR CONTINUING TO SUPPORT THIS PROJECT. THANK YOU. [ APPLAUSE ] >> GOOD AFTERNOON, I'M STEVE LABUTI. I AM DIRECTOR OF THE EINSTEIN CENTER FOR CANCER CARE AT MEDICAL CENTER INIAL BERT EINSTEIN COLLEGE OF MEDICINE IN NEW YORK. PRIOR TO THAT THOUGH, FOR 14 YEARS, HITHE PRIVILEGE OF BEING AN INVESTIGATOR IN THE INTRAMURAL PROGRAM AT THE NATIONAL CANCER INSTITUTE AND IT'S A BIT OF A HOME COMING FOR ME THIS MORNING. OUR INVENTION MAY HE AS THE CO INVENTOR OF THIS INVENTION WORKED AT MY LABORATORY WHEN I WAS A SENIOR INVESTIGATOR HERE. IS FOCUSED ON BREAST CANCER DIAGNOSTIC AND PREDICTION MODEL BASED ON GENOMIC GENE EXPRESSION PROFILING AND MOST OF US KNOW IF YOU CAN DETECT BREAST CANCER EARLY, SURGERY WITH RADIATION MOST OFTEN AND SOMETIMES WITH CHEMO THERAPY, CAN BE CURIAATIVE FOR MANY PATIENTS. BUT FOR PATIENTS, FOR WHOM THE CURE IS ELUSIVE IN TERMS OF SURGICAL AND RADIATION THERAPY, CHEMO THERAPY FOR SYSTEMIC DISEASE OR METASTASIS AND WE HEARD COMPELLING STORIES AND STRUGGLES WITH THE TOXICITY IT TOXICITIES OF THOSE THERAPIES CAN BE A MAJOR CHALLENGE AND WHAT THIS INVENTION IS FOCUSED ON IS PREDICTING UP FRONT AT THIS VERY FIRST DIAGNOSIS OF BREAST CANCER, HOW AGGRESSIVE THE TUMOR IS AND THE LIKELIHOOD OF IT REATURING OR SPREADING AFTER SURGICAL MANAGEMENT AND THEREFORE WILL HOPEFULLY ALLOW US TO IDENTIFY THOSE PATIENTS THAT REQUIRE MUCH MORE INTENSIVE SURVEILLANCE AND FOLLOW UP AND WILL REQUIRE MUCH MORE INTENSIVE THERAPY TO HOPEFULLY AVOID THE TOXICITY OF THERAPIES AND PERSISTENT SURVEILLANCE FOR THOSE PATIENT WHO IS MIGHT NOT NEED IT WHO WILL BE EFFECTIVELY CURED BY SURGERY. THERE ARE ON THE MARKET, SOME GENOMICS BASED ASSAYS BUT MOST OF THEM ARE RESTRICTED TO SPECIFIC TYPES OF BREAST CANCER OR REQUIRE VERY LARGE AND EXPENSIVE PLATFORMS TO DO. THIS INVENTION CAN BE APPLIED TO INTEREST PATIENT WITH BREAST CANCER REGARDLESS OF THEIR SPECIFIC SUBTYPE, AND IT'S BASED ON ONLY SIX GENES THAT HAVE TO BE PROFILED AND SO I AM VERY OPTIMISTIC AND MUCH CONGRATTULESS TO THE TEAM FROM U. C. BURKELY BECAUSE I THINK THEY HAVE A FANTASTIC IDEA OF HOW TO ACTUALLY BRING THIS TECHNOLOGY TO HOPEFULLY MAKE AN IMPACT ON WOMEN SUFFERING FROM BREAST CANCER AND SO I AM THRILLED TO BE A PART THIS. I THINK THE TEAM HAS DONE A TERRIFIC JOB IN PUT THANKSGIVING TOGETHER AND PUTTING IT ON AND I WISH YOU GUYS THE BEST OF LUCK AND CONGRATULATE ON YOUR ACHIEVEMENT SO FAR, THANK YOU. [ APPLAUSE ] >> GOOD AFTERNOON I'M STEVEN YOU HADIT, I AM A COMMANDER IN THE UNITED STATES PUBLIC HEALTH SERVICE, I HAVE THE PLEASURE OF SERVING AS A INVESTIGATOR AT THE CLINICAL CANCER INSTITUTE AND I'M A PATHOLOGIST BY TRAINING AND A COUPLE PERSONAL SPACES, FILL THE SPACE QUICKLY MY GRANDMOTHER DIED OF SEQUELA THERAPY, SHE DIED FROM THE TREATMENT OF BREAST CANCER. IF IT HAPPENED TO ME, SERVING HERE AT. NCI, I WAS SERVING ON A STUDY SECTION OF THE D.O.D. BREAST CANCER INAREAATIVES AND THE WOMAN IN THE ROOM SAID I DON'T NEED MORE POISONING. SHE WAS LOOKING FOR PEOPLE WHO WOULD FOCUS ON PREVENTION, FOCUS ON TARGETED THERAPY AND PROVIDING GUIDANCE IN HOW TO IMPROVE THE THERAPY THAT WOMEN GET. TO MAKE THE THERAPY MORE TARGETED, MORE ON TARGET, MAKE THE RESPONSES REAL. SO, MY INVENTION IS AN APPROACH TO MEASURE TISSUE BIOMARKERS, BIOMARKERS IN THE TUMORS THEMSELVES, TAKE OUT THE TUMOR, LOOK AT THE TUMOR, QUANTIFY THOSE AND THEN COMBINE THEM. EVERYBODY'S FAMILIAR WITH THE ROLE OF ESTROGEN RECEPTOR IN BREAST CANCER, WE TALK ABOUT TAMOXIFEN IS A PRIMARY THERAPY FOR BREAST CANCER AND TALK ABOUT HERTWO, AND HERCEPTIN THE DRUG WE GIVE THR THAT BUT ALL OF OUR TECHNOLOGY ALLOW US TO LOOK AT ONE BIOMARKER. HERTWO. AND PREDICT THE OUTCOME OR RESPONSE TO THAT THERAPY. IN THIS APPROACH THE CAPACITY TO COMBINE MULTIPLE MARKER INTO'S GOOD-BAD. TRY TO MAKE RATIONAL DECISIONWHAT AGENTS ARE APPROPRIATE, GOALS THAT DEVELOP THESE APPROACH SPECIALIZATION OF SPECIFIC ENDOTHELIAL THEY WILL TELL YOU, IS THE DRUG GOING TO WORK OR NOT GOING TO WORK. AS WE MOVE TOWARD MORE TARGETED THERAPY, TO SAY, WHICH TARGETED THERAPY WILL WORK AND HOW WE WILL COMBINE THEM. YOU WILL USE A DRUG THAT TARGETS HER-TWO PATHWAY AND ONE THAT TARGETING SYSTEMYS PROLIFERATION AND DO YOU NEED TO LOOK SOMEWHERE ELSE SO IT'S AN APPROACH OF QUANTIFICATION AND COMBINATTORYIAL WORKINGS WITH BIOMARKERS. I WOULD LIKE TO THANK THE NCI FOR THE PRIVILEGE OF BEING AN INVENTOR HERE. I AM AN INVENTOR, I INVENT AND I HAVE A FEW OTHER INVENTIONS THEY'VE BEEN COMMERCIALLY BRISED THROUGHOUT OTHER STATES BUT WHAT YOU REALIZE IS THAT INVENTION IS ONE THING, COMMERCIALIZATION IS A WHOLE DIFFERENT BASKET, SOMETHING I DON'T DO AND HAVING SOMEBODY STEP FORWARD AND SAY, WE WANT TO TAKE YOUR IDEA AND TURB IT TO THE REAL WORLD IS GREAT. BECAUSE I'M NOT TRAINED AT MARKETING MY INVENTIONS DESPITE WHAT SOME PEOPLE THINK, AND TO HAVE SOMEBODY TAKE MY VISION AND TAKE IT TO THAT NEXT STEP IS JUST A WONDERFUL OUTSTANDING OPPORTUNITY FOR PEOPLE LIKE ME. IT'S A PRIVILEGE TO DO THIS AT THE NKRERKS I. THANK YOU. KD--SALLY ALAW [ APPLAUSE ] >> GOOD AFTERNOON, I'M SHERRY YOUNG FROM DCD NCI. I FIRST WOULD LIKE TO MENTION MY CO-INVENTOR DR. [INDISCERNIBLE] COULD NOT BE HERE TODAY SHE IS A RENOWNED BREAST ONCOLOGIST. OUR INVENTION INVOLVE A DIAGNOSTIC TEST WITH A PROTEIN CALLED A PKET, TO DETECT THE AND [INDISCERNIBLE] OUTCOME. IT'S A POSITIVE [INDISCERNIBLE] FOR CELL [INDISCERNIBLE] A TAXI OF THE BREAST CANCER SURVIVAL KNOWS IT'S IMPORTANT ARTIFACT IT IS, HOWEVER, NOT ALL PATIENTS [INDISCERNIBLE] WITH THE TREATMENT THEY JUST SUFFER THE TOX ISOTOPITY WITHOUT BENEFIT. SO THAT'S WHY OUR INVENTION BASICALLY FORMED P A KT, PATIENTS BENEFIT FROM TAXI TREATMENT. WHILE PATIENTS WITH P A KT TUMOR DO NOT BENEFIT. OUR INVENTION WAS IN COLLABORATION WITH [INDISCERNIBLE] RIGHT NOW, SHE'S AT WASHINGTON UNIVERSITY [INDISCERNIBLE] CENTER AND DOC [INDISCERNIBLE] AND OTHERS AT NATIONAL SURGICAL ADJUVANT BREAST AND [INDISCERNIBLE] PROJECT. THIS IS A FIRST LARGE CORE STUDY FOR TAKING P A KT PREDICTIVE UTILITY FOR CHEMO THERAPY. THROUGH THE DIAGNOSTIC DEVICE THAT'S DEVELOPED BY THE WINNING TEAM [INDISCERNIBLE] UNIVERSITY, I ACCIDENTED--COULDN'T ALLOW PATIENTS TO ELECT TAXI BASED CHEMEE THERAPY THE PATIENT TUMOR OR P A KT POSITIVE, WELL THE PATIENTS WITH P A KT INACTIVE TUMORS, IT'S GOING TO BE SPARE FRIDAY SUCH TREATMENT. THANK YOU VERY MUCH. [ APPLAUSE ] >> THANK YOU VERY MUCH, THAT WAS GREAT INVENTORS NICE TO HEAR ALL OF YOU TALK ABOUT YOUR INVENTIONS YOURSELF. I JUST WANT TO REACH OUT TO THE PEOPLE WHO ARE ON THE VIDEOCAST. I HOPE YOU'RE ALL STILL WITH US. NEXT I WOULD LIKE TO INTRODUCE ANOTHER BREAST CANCER SURVIVOR IS ALSO PARTNER IN FINNEGAN WHICH IS A LAW FIRM IN WASHINGTON D. C. VERY LARGE LAW FIRM, INTELLECTUAL PROPERTY FIRM. SHE WILL TALK ABOUT HER STORY AND ALSO HOW THESE INVENTIONS COULD HAVE POSSIBLY HELPED HER IN HER JOURNEY. >> HELLO, AM I THE ONLY ONE IN ROOM WHO HAS BEEN CRYING THIS WHOLE TIME. I WANT TO THANK THE ORGANIZATION FOR START THANKSGIVING PROGRAM, IT'S REALLY, REALLY TERRIFIC, THE INVENTIONS THAT ARE OUT THERE, THE PROGRESS THAT'S MADE WITH THEM, THE IMPACT IT HAS ON PEOPLE'S LIVES. AND TAKING SOMETHING THAT'S ACTUALLY BEEN INVENTED AND IMPLEMENTED IT IN A FAIRLY SHORT AMOUNT OF TIME I HAD WHAT I CALL SORT OF A WORST EXPERIENCE WITH CANCER AND THEN SORT OF THE BEST POSSIBLE EXPERIENCE WITH CANCER. IN 2008 I HAD A COUSIN WHO WAS DIAGNOSED WITH COLON CANCER AND HE WAS STAGE FOUR AND IT TURNS OUT WHEN YOU'RE AT STAGE FOUR THERE'S ANOTHER GRADATION AND HE WAS STAGE FOUR THAT, TOO AND THE DOCTORS PREDIBLGHT THAD YOU KNOW HE WOULD MAYBE SURVIVE ANOTHER SIX MONTHS. AND THE DOCTORS WERE RIGHT. AND THE IMPACT AND THAT WAS ABOUT FIVE YEARS AGO, THE IMPACT ON HIS FAMILY WAS YOU KNOW VERY VISIBLE. YOU KNOW THEY'RE STILL STRUGGLE ING WITH IT AND WHAT THEY HAD TO GO THROUGH AND GO WITH A SON WHO WAS NOT EVEN 30, BEING AT STAGE FOUR AND NOTHING THEY COULD DO WITH THAT. ABOUT SIX MONTHS AFTER THAT, I NOTICED--I FELT LIKE SOMEONE STUCK AN ALMOND IN MY BODY, THERE'S A DOG AND THERE'S A SQUIRREL THAT'S HIDING A NUT IN HIS FUR AND I DIDN'T THINK SHOULD BE HERE, I'LL GET IT CHECKED OUT, YOU KNOW I WENT TO MY DOCTOR, SHE CHECKED ME OUT SAID I DON'T THINK IT'S ANYTHING BUT GO GET IT FOLLOWED UP AND I HAD A MAMMOGRAM, AND I--THERE ARE DIFFERENT BIOPSY OPTIONS AND I SAW A SURGEON AND SHE LOOKED AT FILMS SHE SAID IT DOESN'T GROW PERPECKLY ROUND BUT GET A BIOPSY, YOU DON'T NEED A SURGICAL ONE SO HIMY BIOPSY DONE AND I MET WITH THE RADIOLOGIST AFTERWARDS AND HE SAID YEAH I DON'T THINK IT'S GOING TO BE ANYTHING, SO YOU KNOW WE'LL CALL AND YOU GET IT CONFIRMED AND THAT WAS A FRIDAY IN APRIL AND HE CALL ME IN TUESDAY AND SAID WELL HAVE YOU LOBULAR CARCINOMA I THOUGHT MY RESPONSE WAS PERFECTLY REASONABLE AND I SAID DO NEED TO HAVE IT REMOVED AND SHE SAID YEAH, YOU SHOULD. AND I FRIDAY I HAD APPOINTMENT WITH ANOTHER DOCTOR AND SHE WAS GOING THROUGH SORT OF LIKE THIS DECISION TREE OF YOU KNOW YOU CAN HAVE A MASTECTOMY, LUMPECTOMY, YOU KNOW IF IT'S SPREAD TO YOUR NODES TO YOUR LYMPHNODES, WE'LL ON TO RADIATION AND IT WAS THIS AND IT WAS BASICALLY THIS DECISION OF TREE OF REALLY AWFUL OPTIONS AND I DIDN'T LIKE ANY OF THEM AND I STOPPED HER PART WAY THROUGH AND I SAID I DON'T HAVE CANCER AND THE POOR WOMEN DIDN'T KNOW WHAT TO DO WITH THAT BECAUSE SHE WAS BT EXPECTING IT SO SHE JUST KIND OF FROZE AND FINALLY SAID, YES YOU DO. AND THAT WAS KIND OF WHEN I REALIZED THAT OH, OKAY. SO I ENDED UP GOING TO HOPKINS FOR THE SURGERY AND MY INFORMATION, MY BACKGROUND IS PHYSICS, SO MY KNOWLEDGE OF YOU KNOW SORT OF CANCER AND TREATMENT, COMES FROM WHAT MAY DOCTOR TOLD ME WHAT I READ AND UNFORTUNATELY THE INTERNET. SO I HAVE THIS AMALGUM OF INFORMATION, SOME OF RELIABLE, SOME OF IT TERRIVE AND I CAN SOME OF WHERE I TAKE IT WITH A GRAIN OF SALT. SO ANYWAY, HITHE SURGERY AND THAT WENT FINE. DOCTOR WAS FABULOUS. IT HAD NOT SPREAD TO MY LYMPHNODES DIDN'T HAVE TO HAVE RADIATION WHICH HAS VERY SIGNIFICANT IMPACT FOR THE RECONSTRUCTIVE OPTIONS THAT ARE AVAILABLE. AND I HAD THE ONK O TYPE AND I WAS EXPSYCHESSED ABOUT CREDIT DR. AL ATUDEYE'S INVENTION BUT I HAD A LOW ENOUGH SCORE THEY DIDN'T HAVE TO HAVE CHEMO THERAPY AND YOU KNOW THE IMPACT, IT WAS STILL JUST A TERRIBLE, TERRIBLE THING. BUT THE IMPACT OF SORT OF HAVING THAT BEST CASE SCENARIO, OF NOT HAVING THE LONG AND SHORT-TERM IMPACT OF WHAT SORT OF CHEMO DOES TO YOU, WHAT RADIATION DOES, HOW IS IMPACTS OPTIONS IT WAS TREMENDOUS. AND COMPARED TO MY COUSIN FROM THE YEAR BEFORE, IT WAS JUST SORT OF HOW BAD IT CAN BE AND THEN SORT OF HOW GOOD IT CAN BE WITH THE PROGRESS OF TECHNOLOGY AND YOU KNOW HAVING GOOD DOCTORS AND YOU KNOW MAKING THE RIGHT DECISIONS I'M HONESTLY FOREVER GLAD I WENT TO HOPKINS FOR MY SURGERY. BUT IT REALLY MADE A TREMENDOUS DIFFERENCE. THE INVENTIONS THAT PEOPLE ARE COMING OUT WITH AND I ACTUALLY, YOU KNOW BRINGING THEM TO PATIENTS, THAT'S WHAT'S NEEDED. YOU KNOW IT'S GREAT TO HAVE AN IDEA, BUT THERE'S A LONG PROCESS OF ACTUALLY BEING ABLE TO IMPLEMENT IT AND BE ABLE TO TREAT MACHINE WITH IT AND GETTING TO THAT POINT WHERE IT MAKES A VERY TANGIBLE REAL DIFFERENCE IN A PERSON'S LIFE IS HUGE. BECAUSE YOU KNOW IT IS SIGNIFICANT. IT IS CHANGING SHORT-TERM LIFE, LONG-TERM LIFE, AND THEY SURVIVE, AND THEY DON'T SURVIVE. YOU KNOW, BUT THEN ALSO LET'S SAY THE PERSON SURVIVES, I DID--WHAT YOUR LIFE IS LIKE AFTER THAT, IT MAKES AN EMOMMOUS DIFFERENCE, SO I'M VERY GRATEFUL FOR THIS PROGRAM. I'M SORRY I HAVE TO SPEAK AFTER LILLY WHO IS VERY ELEGANT, HONESTLY ONE OF MY PERSONAL HEROS AND IF ANYONE WANTS TO READ A BOOK ON SORT OF BREAST CANCER GOING THROUGH IT, SHE HAS I THINK IN MY OPINION THE BEST ONE THE. FIRST OF ALL THEY'RE SHORT BUT THEY'RE ALSO VERY INFORMATIVE AND THEY GIVE YOU THE INFORMATION THEY NEED. BUT ONE OTHER THING I WANT TO POINTS OUT FOR PEOPLE WHO ARE COMING UP WITH IDEAS AND TRYING TO GET THEM TO MARKET AND GET THEM TO PATIENTS, ONE OF THE THINGS SHE DID WAS BASICALLY GOT CONGRESS TO CHANGE THAT RECONSTRUCTIVE SURGERY IS APPROVED BY INSURANCE. SO IF ONE PERSON CAN MAKE A DIFFERENCE IN CONGRESS, THERE'S A HUGE OF AMOUNT DIFFERENCE YOU CAN MAKE IN PROGRESS THAT CAN BE ACCOMPLISHED, BY PERSEVERANCE AND BY JUST HAVING REALLY SMART, REALLY DEDICATED PEOPLE WORKING AT THIS. THANK YOU. >> THANK YOU FOR SHARING YOUR STORY. FANTASTIC AND WE WANT TO THANK YOU FOR YOUR FIRM'S GENEROUS SUPPORT FOR THIS EVENT. >> NOW THE MOMENT YOU'VE ALL BEEN WAITING FOR, I TOLD YOU YOU WOULD GET YOUR MONEY. WILL WE WILL PRESENT THE TROPHIES OR THE PLAQUES TO YOU ALL. AND HELP ME IF I MISPRONOUNCE YOUR NAME. I'VE BEEN PRACTICING BUT NOT SURE IF I GOT THEM ALL SO I FIRST WANT TO HAVE FOR INVENTION NUMBER TWO, WASHINGTON UNIVERSITY IN ST. LOUIS. WHITNY GRITHER. [ APPLAUSE ] >> NEXT I WOULD LIKE TO CONGRATULATE TULANE UNIVERSITY, P A RITUDE KERSHAKLA. CONGRATULATIONS. [ APPLAUSE ] CONGRATULATIONS. NEXT STANFORD UNIVERSITY, GRAHAM FIELDER AND FRANCIS HUNTER. [ APPLAUSE ] >> THANK YOU. THEY FLEW A VERY LONG WAY TO GET HERE, LET ME TELL YOU. I DON'T KNOW IF THEY'VE SLEPT FOR THE LAST SEVERAL, SEVERAL HOURS. NEXT I WOULD LIKE TO CONGRATULATE NORTHWESTERN UNIVERSITY DANIEL LE VENE AND JOHN CULPER. [ APPLAUSE ] NEXT I WOULD LIKE TO CONGRATULATE RUTGERS UNIVERSITY FOR INVENTION NUMBER SIX. SIR ROB SENHAU AND RILEY SINIS. [ APPLAUSE ] >> CONGRATULATIONS. >> NEXT I'D LIKE TO CONGRATULATE FOR INVENTION NUMBER EIGHT, U. C. BURKELY, GYRE ARD O RAMIREZ AND NEVENE --THANK YOU. KD--SALLY LAUGHT [LAUGHTER] [LAUGHTER] >> [ APPLAUSE ] >> NEXT Mc GILL UNIVERSITY FOR INVENTION NUMBER NINE DISCIPLINARY MITT RI. --DEMEET RI. --DIMETRI. [ APPLAUSE ] KARATIDI. SORRY. [LAUGHTER] ALSO WE HAVE TWO FINALISTS ONE THAT WISCONSIN UNIVERSITY. BRIANA? [ APPLAUSE ] PRIZULSKI. >> IS WAKE FOREST. GREAT, GONZO, COME ON UP, SO GONZO FROM WAKE FOREST ESTUPION. THANK YOU FOR INVENTION NUMBER SEVEN. [ APPLAUSE ] AND THE LITTLE PIECES OF PAPER ON THE BACK ARE MONEY. SO THAT'S YOUR MONEY. AND FINALLY I WOULD ALSO LIKE TO THANK ONE OF OUR VERY SUCCESSFUL FUNDERS IN MARYLAND WHO ACTUALLY COACHED US AS WE FORMULATED THE CONCEPT FOR THIS CHALLENGE. IT'S WITH GREAT PLEASURE I INTRODUCE STEVEN OVILLE, SENIOR VICE PRESIDENT OF TECHNOLOGY TRANSFER AND COMMERCIALIZATION AT THE MARYLAND TECHNOLOGY DEVELOPMENT CORPORATION. >> GOOD AFTERNOON, EVERYONE, IT'S BEEN QUITE A AN EFFECT TODAY. A LOT OF GREAT STORIES, IT'S KIND OF TOUGH TO FOLLOW MANY OF THEM BUT I WANT TO THANK ROSEMARIE TO SPEAK AND BE PART OF THIS EVENT BECAUSE I THINK IT'S SO IMPORTANT. AND I WANT TO I WANT TO THANK ALL OF THE--ALL OF THE PARTICIPANTS IN IN PROGRAM AS WELL BECAUSE WITHOUT YOU THERE'S NO BUSINESS PLAYING COMPETITION AND I WANT TO CONGOTTULATE YOU AS WELL BECAUSE IT'S--IT'S NOT A SIMPLE FT.--FEAT TO DO WHAT YOU'VE DONE WHEN YOU LOOK AT PRESTIGIOUS UNIVERSITIES THAT PARTICIPATE INDEED THIS, ACROSS THE COUNTRY AND ACROSS THE GLOBE AND TO BE ABLE TO WIN THIS COMPETITION AND WITH THAT KIND OF COMPETITION IS NO SMALL FEAT. SO THANK YOU FOR PARTICIPATING AND I WANT TO THANK ROSEMARIE'S ORGANIZATION, AND AVON AND NCI FOR ORGANIZIZING THIS PROGRAM BECAUSE IT'S IMPORTANT FOR DOING WHAT YOU NEED DO IS HELPING PATIENTS ULTIMATELY. SO I WANT TO NEXT TURN TO MY ORGANIZATION. TETCO, AS ROSEMARIE MENTIONED, SHE GAVE AWAY MONEY. NOW WE'LL TALK ABOUT MONEY AND WE'RE ONE OF THE ORGANIZATIONS THAT SUPPORT THIS IS EFFORT AND OFTEN PROVIDE THE FIRST MONEY INTO COMPANIES LIKE YOURS AND TETCO WAS FORMED 15 YEARS AGO TO REALLY FOSTER THIS TRANSITION OF TECHNOLOGY FROM THE LABORATORY INTO THE COMMERCIAL SECTOR IN DOING, YOU KNOW FROM NOT ONLY NCI AND THE FEDERAL LABORATORIES BUT ALSO FROM THE UNIVERSITIES AND WE'RE COMBLESSED IN THIS REGION TO HAVE SO MUCH, SO MUCH RESOURCE IN TERMS OF THE RESEARCH THAT'S GOING ON IN THIS REGION, SO WE AT TETCO THINK ALL THE TIME ABOUT HOW DO WE DO IT BETTER AND WE CERTAINLY THROUGHOUT A LOT OF RESOURCES TALK ABOUT HOW DO WE DO THIS AND WE'RE THINKING ABOUT HOW DO WE DO THIS BETTER BECAUSE IT'S SO IMPORTANT AND WHEN TOM SCHEROSEMARIE CAME TO SIT DOWN AND THEY SAID THIS IS WAWE'RE TRYING TO DO AND TRY TO PUT A BUSINESS PLAN COMPETITION TO HELP COMMERCIALIZE TECHNOLOGIES OUT OF THE NCI TO REALLY HELP PATIENTS, YOU KNOW IT WAS LIKE HOW CAN WE GET INVOLVED, HOW CAN WE HELP OUT. SO AGAIN WE'RE SO GLAD TO BE PART OF IT. AND LIKE--LIKE MANY OF THE OTHER SPEAKERS BUT MAYBE NOT TO THE DEGREE, I MEAN BREAST CANCER'S TOUCHED ME AS WELL. MY MOM FOUGHT IT FOR 17 YEARS AND FINALLY SUCCUMBED TO IT SO IT'S SOMETHING THAT I THINK IMPACTS ALL OF US EVEN THOUGH WE DON'T GET IT. SO AGAIN, THERE'S A PERSONAL REASON WHY I WAS VERY INTERESTED IN SUPPORTING THIS AS WELL. SO WHILE THE BUSINESS PLAN COMPETITION IS SUCH A GREAT ACCOMPLISHMENT, I HAVE TO SAY THOUGH THE HARD WORK STARTS NOW, RIGHT? SO WE--IF YOU LOOK AT HOW MUCH MONEY WE SPEND IN RESEARCH. WE HAVE THESE TERRIBLE DISEASES, WE'RE REALLY TRYING TO FIGHT THEM AND FIND CURE FIST ARE THEM, THAT'S OLDSMOBILE PART OF THE STORY BECAUSE THE OTHER--THE SECOND PART IS HOW DO WE GET PRODUCTS THAT ACTUALLY HELP PATIENTS OF THE IT'S LIKE WE'RE AT THE 50 YARD-LINE, WE HAVE 50-YARDS TO GO, SWREE ON GET ACROSS THE FINISH LINE TO MAKE THE CURES TOXIC EFFECTS GET THE PROPER DIAGNOSE AND I GUESS THAT'S WHERE YOU GUYS WILL FALL IN, HAVE YOU THE BALL, YOU KNOW, HAVE YOU A LOT OF SUPPORT TO CARRY IT ACROSS THAT GOAL LINE BUT YOU KNOW, WE ENCOURAGE YOU TO DO THAT AND WHAT I WANT TO MENTION IS, THERE'S A LOT OF RESOURCES OUT THERE, FOR ENTREPRENEURS AND WE AT TETCO WORK IN A LOT OF AREAS AND FIRST THING I WANT TO SAY IS DON'T HESITATE TO ASK FOR SUPPORT BECAUSE YOU WILL BE AMAZE TED AT THE FOLKS THAT ARE WILLING TO BEND OVER BACKWARDS AND GIVE YOU TIME TO SUPPORT YOU AND HELP YOU TO BE SUCCESSFUL AND I THINK ANYBODY IN THIS ROOM WOULD HELP YOU TO DO THAT. SO I WANT TO ENCOURAGE TO YOU DO THAT. SPECIFICALLY IN TERMS OF THE FUNDING PROGRAMS, WE'RE ONE ORGANIZATION FOCUSED IN MARYLAND, ONE ORGANIZATION LIKE OURS THROUGHOUT THE COUNTRY BUT WE HAVE PROGRAMS, ONE CAR MARYLAND ENTREPRENEUR RESOURCE LIST, ANY SUCCESSFUL ENTREPRENEUR WILL TELL YOU, YOU CAN'T DO IT ON YOUR OWN. YOU HAVE TO BUILD A TEAM YOU HAVE TO GET DIFFERENT TYPES OF EXPERTISE AND WE HAVE PROGRAM YOU CAN GO AND LOOK UP FOLKS WITH THE RIGHT KIND OF EXPERTISE ON OUR WEB SITE AND CAN YOU CALL THEM AND THEY'VE AGREED, BY PUTTING THEIR NAMEOT LIST TO WORK WITH YOU AND TO SUPPORT YOU. SO WE WANT TO DO THAT. WE HAVE ANOTHER PROGRAM IF YOU'RE A MARYLAND COMPANY, YOU'RE LICENSING TECHNOLOGY OUT OF THE--OUT OF THE NIH AND YOU USE THEIR EXPRESS LICENSE, CAN YOU ACTUALLY GET--WE HAVE A PROGRAM TO PAY FOR SOME OF THE ONGOING PATENT EXPENSES YOU'LL BE REQUIRED TO PAY BACK TO THE NIH'S PART OF THAT DEAL. AND THE NIH EXPRESS LICENSE IS ACTUALLY A GREAT MECHANISM FOR START UP COMPANIES TO LICENSE TECHNOLOGIES BECAUSE THEY--THEY HAVE SOME GREAT TERMS IN THEIR FOR YOU. SO I WOULD ENCOURAGE YOU TO LOOK AT THOSE KINDS OF PROGRAMS, OUR KEY PROGRAM SYSTEM TECHNOLOGY COMMERCIALIZATION FUND THAT WILL PROVIDE IT FOR MARYLAND COMPANIES BUT YOU WOULD QUAL FOR FOR THE COMPANY BECAUSE YOU'RE COMMERCIALSING IT OUT OF THE NCI OR NIH, THAT'S A HUNDRED THOUSAND DOLLARS TO GET YOUR COMPANY GOING, TO ACHIEVE THAT MILESTONE SO CAN YOU GO OUT AND RAISE THE NEXT ROUND OF MONEY, RIGHT BECAUSE IT'S ALL--THE FUNDRAISING YOU NEED TO DO FOR THESE TECHNOLOGIES, IT'S A LONG DRAWN OUT PROCESS AND IT'S GOTTA BE MILESTONE BASED AND YOU NEED LITTLE CHUNKS OF MONEY UPFRONT TO ACHIEVE MILESTONES SO CAN YOU GO OUT TO THE VENTURE COMMUNITY AND ANGEL COMMUNITY AND RAISE MILLIONS OF DOLLARS THAT YOU WILL NEED. SO WE'RE DOLLAR TO SUPPORT THAT, MARYLAND HAS A NUMBER OF OTHER RESOURCES FOR YOU AS WELL FROM THE MARYLAND BIOTECHNOLOGY CENTER. THERE'S DATABASES TO HELP YOU AND RESEARCH AND FILL OUT YOUR BUSINESS PLAN. LOTS OF BUSINESS INCUE BATION RESOURCES AND OTHER REGIONS SHOULD YOU DECIDE TO START YOUR COMPANY IN OTHER PLACES AND CERTAINLY AT OUR WEB SITE, TETCO.MDPATHWAY GIVES YOU CAN FIND MORE ABOUT THIS INFORMATION. SO WHETHER YOU START HERE IN MARYLAND OR SOMEWHERE ELSE, YOU KNOW I WANT TO CONGRATULATE YOU AGAIN AND I WANT TO WISH YOU THE BEST OF LUCK IN YOUR JOURNEY ACROSS THAT GOAL LINE. SO THANK YOU. [ APPLAUSE ] >> THANK YOU STEPHEN AND NOW I'D LIKE TO INTRODUCE DR. DOUG LOWY, DEPUTY DIRECTOR FOR THE NATIONAL CANCER INSTITUTE AND HAS BEEN A WONDERFUL SUPPORTER OF THIS CHALLENGE AND HE WILL CLOSE US OUT A BIT WITH A FEW WORDS OF HOW THIS IS IMPORTANT FOR THE NATIONAL CANCER INSTITUTE. >> THANK YOU TOM. GOOD AFTERNOON AND I GUESS ON SOME LEVEL THIS IS IN CONTRAST WHAT HAS ALREADY BEEN SAID THIS, MAY BE THE TALK YOU HAVE BEEN WAITING FOR. [LAUGHTER] >> AND I THINK THAT PERHAPS THE MOST IMPORTANT THING THAT I CAN SAY IS THAT YOU REALLY HERE SEEM TO BE FULFILLING A MISSION AND GOAL FOR WHICH WE, THE NATIONAL CANCER INSTITUTE ARE NOT WELL PREPARED. AND I REALLY WANT TO CONGRATULATE BOTH ROSEMARY AND TOM FOR PULLING THIS TOGETHER, HAVING THE IDEA OF DOING THIS AND ALSO THE AVON FOUNDATION FOR BEING WILLING TO TAKE THE RISK OF SUPPORTING IT AND FOR THE STUDENTS, FOR REALLY COMPETING VERY EFFECTIVELY IN TRYING TO ESSENTIALLY MAKE PROPOSALS BECAUSE AS STEVE YOU HAD SAID ONE OF THE THINGS WE DON'T DO WELL IS BUSINESS HERE AT NCI AND WE WOULD LIKE TO THINK THAT YOU ALL CAN DO THAT A LOT MORE EFFECTIVELY THAN WE CAN. WE THINK WE'RE PRETTY GOOD AT DOING THE RESEARCH. WE'RE THINK WE'RE PRETTY GOOD AT SUPPORTING RESEARCH EXTRAMURALLY FROM OUR EXTRANSLATIONAL RESEARCH MURAL INVESTIGATORS, AND WE REALLY APPRECIATE THE EFFORTS YOU ALL ARE MAKING. THESE INVENTIONS REALLY DIVIDE THEMSELVES BETWEEN WHAT I WOULD CALL PREDICTIVE ONCOLOGY AND THERAPEUTICS. I AGREE THAT PREVENTION IS VERY IMPORTANT BUT THAT'S STILL TO A LARGE DEGREE IN THE RESEARCH AREA, EXCEPT FOR INTERVENTIONS SUCH AS TRYING TO INTERFERE WITH ESTROGEN PRODUCTION OR ESTROGEN--ESTROGEN ACTIVITY AT THE MOMENTENT BUT I'M HOPEFUL THAT YEARS GO ON, THERE WILL BE MORE PREVENTION ORIENTATION. BUT RIGHT NOW, IT'S REALLY CRITICAL THAT WE TRY TO ESSENTIALLY ESTABLISH A SCIENTIFIC BASIS FOR GOLDY LOCK APPROACHES FOR TREATMENT THAT IS NOT TOO MUCH, AND NOT TOO LITTLE SO THAT THE AREA OF PREDICTIVE ONCOLOGY BECOMES PROGRESSIVELY MORE PREDICTIVE. IN ADDITION WHEN PEOPLE NEED TO BE TREATED, OBVIOUSLY, A LOT OF THE CURRENT TREATMENTS THAT WE HAVE ALREADY DO A LOT ALTHOUGH I CERTAINLY AGREE THAT MANY OF THEM ARE ALSO ASSOCIATE WIDE SUBSTANTIAL TOXICITY. BUT BEING ABLE TO HAVE NEW MODALITIES THAT ARE ABLE TO DO THINGS IN TREATMENTS, THAT CURRENT MODALITIES CAN'T. I THINK IS--I THINK IS VERY IMPORTANT. I WANT TO SAY ONE OTHER THING ABOUT SOMETHING THAT AT LEAST STRIKES ME AS BEING VERY IMPORTANT BECAUSE WHILE I THINK THAT IT'S CRITICAL TO BE ORIENTED TOWARDS PARTICULAR KINDS OF CANCERS, ONE OF THE IMPORTANT THINGS WE HAVE LEARNED FROM STUDYING THE MOLECULAR BIOLOGY OF CANCER IS HOW OFTEN DISCOVERIES MADE IN ONE KIND OF CANCER MAY HAVE APPLICATION TO OTHER KINDS OF CANCER AND NOT TO SINGLE OUT MITCHELL'S INVENTION AS BEING THE BEST OR ANYTHING LIKE THAT BUT IT EXEMPLIFIES THAT BECAUSE THE IDENTIFICATION OF MESOTHELIN WAS IN STUDYING A VERY UNCOMMON CANCER WHICH IS CALLED MESOTHELIOMA AND YET IT'S TURNED OUT THAT THE IDENTIFICATION OF MESOTHELIN AND MESOTHELIOMA MAY LEAD TO A NEW TREATMENT OF APPROACH FORS VARIETIES OF OF MALIGNANCIES SO I WANT TO APPLAUD ALL OF YOU FOR YOUR EXPOSURE TO EFFORTS AND THE STUDENT W HO IS WON. YOU ARE HELPING US AS YOU ARE HELPING THE WORLD AND YOURSELVES. THANK YOU SO MUCH. [ APPLAUSE ] >> SO WITH THAT WE CLOSE THE CEREMONY. I WOULD LIKE TO NOTE THAT WE HAVE--LIGHT REFRESHMENTS THAT HAVE BENIOUSLY PROVIDED FOR AVON, CENTER FOR ADVANCING INFORMATION AND FINNIGAN AND CUP CAKES AND FRUIT TRAYS AND WATER SO PLEASE HELP YOURSELF AND ENJOY THE REST OF THE AFTERNOON, THANK YOU. [ APPLAUSE ]