1 00:00:05,271 --> 00:00:09,242 GOOD MORNING, EVERYONE. 2 00:00:09,309 --> 00:00:10,610 AND THIS IS THE ANNUAL MEETING 3 00:00:10,677 --> 00:00:15,014 AS THE FIRST ONE WHERE WE CAN 4 00:00:15,081 --> 00:00:20,620 SEE THE EACH OTHER. 5 00:00:20,687 --> 00:00:27,994 I'M DR. INNA BELFER AT THE NCCIH 6 00:00:28,061 --> 00:00:32,465 AND AND BEHALF OF FELLOW NCCIH I 7 00:00:32,532 --> 00:00:35,769 WOULD LIKE TO WELCOME YOU ALL TO 8 00:00:35,835 --> 00:00:37,604 THE FIFTH ANNUAL P.I. MEETING 9 00:00:37,670 --> 00:00:41,608 FOR THE PROGRAM CALLED EXPLORING 10 00:00:41,674 --> 00:00:45,445 MECHANISMS UNDERLYING ANALGESIC 11 00:00:45,512 --> 00:00:47,213 OF MINOR CANNABINOIDS AND WE'LL 12 00:00:47,280 --> 00:00:50,750 BEGIN WITH WELCOME REMARKS FROM 13 00:00:50,817 --> 00:00:55,522 THE LEADER OF THE PROGRAM, DAVID 14 00:00:55,588 --> 00:00:57,023 SHURTLEFF AND MEETING OVERVIEW 15 00:00:57,090 --> 00:00:59,959 AND GOALS BY DR. EMMELINE 16 00:01:00,026 --> 00:01:01,594 EDWARDS DIRECTOR OF NCCIH 17 00:01:01,661 --> 00:01:12,205 DIVISION OF EXTRAMURAL RESEARCH. 18 00:01:25,885 --> 00:01:35,962 >> OKAY. 19 00:01:48,475 --> 00:01:48,842 OKAY. 20 00:01:48,908 --> 00:01:50,410 THANK YOU. 21 00:01:50,477 --> 00:01:53,346 WE'RE STILL WORKING OUT -- WE'RE 22 00:01:53,413 --> 00:01:55,782 NOT USED TO BEING BACK IN PERSON 23 00:01:55,849 --> 00:02:03,323 APE -- ANYMORE IT TAKES LONGER 24 00:02:03,389 --> 00:02:07,760 TO DO THINGS AND THIS IS OUR 25 00:02:07,827 --> 00:02:08,862 FIFTH ANNUAL MEETING, OUR FIRST 26 00:02:08,928 --> 00:02:11,231 IN PERSON AND PROBABLY OUR LAST 27 00:02:11,297 --> 00:02:11,898 P.I. MEETING FOR THE PROGRAM 28 00:02:11,965 --> 00:02:15,401 THAT STARTED IN JANUARY OF 2019 29 00:02:15,468 --> 00:02:20,807 WHEN WE ISSUED A REQUEST FOR 30 00:02:20,874 --> 00:02:24,444 APPLICATIONS FOR INTEREST FOR 31 00:02:24,511 --> 00:02:32,252 CANNABINOID AND PUR TURPINE 32 00:02:32,318 --> 00:02:39,759 RESEARCH AND WE FUNDED $3 33 00:02:39,826 --> 00:02:50,370 MILLION WITH FEEL LIKE WE MOVED 34 00:02:51,471 --> 00:02:56,409 THE NEEDLE ON THERAPEUTICS WITH 35 00:02:56,476 --> 00:02:56,676 CANNABIS. 36 00:02:56,743 --> 00:03:00,713 HOW DID WE GET HERE? 37 00:03:00,780 --> 00:03:02,348 SO AS THE NATIONAL CENTER FOR 38 00:03:02,415 --> 00:03:04,183 COMPLEMENTARY AND INTEGRATIVE 39 00:03:04,250 --> 00:03:07,554 HEALTH, WE REALLY STUDIED THE 40 00:03:07,620 --> 00:03:11,057 RIGOROUS DETERMINATES THROUGH 41 00:03:11,124 --> 00:03:12,892 RIGOROUS SCIENTIFIC 42 00:03:12,959 --> 00:03:13,826 INVESTIGATION THE SAFETY OF 43 00:03:13,893 --> 00:03:15,194 COMPLEMENTARY AND INTEGRATIVE 44 00:03:15,261 --> 00:03:15,795 HEALTH APPROACHES WHICH IS 45 00:03:15,862 --> 00:03:16,229 GREAT. 46 00:03:16,296 --> 00:03:18,064 WE LOOK AT THE WHOLE PERSON AND 47 00:03:18,131 --> 00:03:19,766 THINK OF PHYSICAL APPROACHES AND 48 00:03:19,832 --> 00:03:21,267 PSYCHOLOGICAL AND FOR THE 49 00:03:21,334 --> 00:03:23,269 PURPOSES OF THIS MEETING, 50 00:03:23,336 --> 00:03:26,573 NUTRITIONAL APPROACHES INCLUDING 51 00:03:26,639 --> 00:03:27,974 BIOLOGICAL ACTIVITIES OF NATURAL 52 00:03:28,041 --> 00:03:31,511 PRODUCTS, DIETARY SUPPLEMENTS, 53 00:03:31,578 --> 00:03:33,146 BOTANICALS WHICH OF COURSE 54 00:03:33,212 --> 00:03:35,181 CANNABIS FALLS INTO AND 55 00:03:35,248 --> 00:03:35,448 VITAMINS. 56 00:03:35,515 --> 00:03:37,050 WHEN WE THINK ABOUT WHEN WE'RE 57 00:03:37,116 --> 00:03:38,284 GOING TO INVEST IN A PARTICULAR 58 00:03:38,351 --> 00:03:39,352 AREA OF SCIENCE WE THINK ABOUT 59 00:03:39,419 --> 00:03:41,921 TWO THINGS, IS THERE ENOUGH 60 00:03:41,988 --> 00:03:47,527 RIGOROUS PRE-CLINICAL RESEARCH 61 00:03:47,594 --> 00:03:50,530 TO SUPPORT FURTHER STUDY SECOND 62 00:03:50,597 --> 00:03:52,532 IS IT BEING USED BY THE AMERICAN 63 00:03:52,599 --> 00:03:55,802 PUBLIC AND CANNABIS CHECKS BOTH 64 00:03:55,868 --> 00:04:02,508 BOXES IT'S ESTIMATED 55 MILLION 65 00:04:02,575 --> 00:04:05,945 AMERICANS HAVE USED MARIJUANA 66 00:04:06,012 --> 00:04:07,714 AND 83 MILLION REPORT USING 67 00:04:07,780 --> 00:04:09,849 CANNABIS FOR MEDICAL USE. 68 00:04:09,916 --> 00:04:12,919 CLEARLY WE CHECK THE BOX ON ITS 69 00:04:12,986 --> 00:04:15,755 USE BY THE AMERICAN PUBLIC AND 70 00:04:15,822 --> 00:04:17,657 THERE IS A LOT OF GOOD BASIC 71 00:04:17,724 --> 00:04:21,027 SCIENCE TO SUGGEST WE UNDERSTAND 72 00:04:21,094 --> 00:04:23,262 THE ENDOCANNABINOID SYSTEM AND 73 00:04:23,329 --> 00:04:25,765 KNOW A LOT IN GENERAL AND THE 74 00:04:25,832 --> 00:04:27,500 REASON NCCIH DECIDED TO TAKE A 75 00:04:27,567 --> 00:04:29,135 LEAP INTO STUDYING CANNABIS. 76 00:04:29,202 --> 00:04:35,742 AND TO REITERATE THAT IN FACT 77 00:04:35,808 --> 00:04:38,945 NOW -- ALLERGIES ARE KICKING IN 78 00:04:39,012 --> 00:04:39,379 TODAY. 79 00:04:39,445 --> 00:04:45,585 24 STATE AND THE DISTRICT OF 80 00:04:45,652 --> 00:04:50,056 COLUMBIA LEGALIZED MARIJUANA AND 81 00:04:50,123 --> 00:04:51,524 OTHERS HAVE LEGALIZED IT FOR 82 00:04:51,591 --> 00:04:52,558 MEDICAL USE AND IT'S AN 83 00:04:52,625 --> 00:04:54,260 OPPORTUNITY FOR THE PUBLIC TO 84 00:04:54,327 --> 00:04:55,762 USE IT WIDELY. 85 00:04:55,828 --> 00:05:01,601 IT'S A BIT OF A DICHOTOMY UNDER 86 00:05:01,668 --> 00:05:04,203 FEDERAL LAW IT'S SCHEDULED 87 00:05:04,270 --> 00:05:05,371 MEANING HIGHLY RESTRICTED IN 88 00:05:05,438 --> 00:05:08,374 TERMS OF ACCESS AND AVAILABILITY 89 00:05:08,441 --> 00:05:10,176 WITH AVAILABILITY THROUGH THE 90 00:05:10,243 --> 00:05:11,911 MISSISSIPPI AND NOW NEW GROWERS 91 00:05:11,978 --> 00:05:14,147 HAVE COME ONLINE THE DRUG 92 00:05:14,213 --> 00:05:15,748 ENFORCEMENT AGENCY APPROVED. 93 00:05:15,815 --> 00:05:18,518 THERE'S A VARIETY OF 94 00:05:18,584 --> 00:05:19,752 CANNABIS-BASED PRODUCTS THAT 95 00:05:19,819 --> 00:05:22,255 HAVE MOVED FORWARD TO FDA NOT 96 00:05:22,321 --> 00:05:32,799 SCHEDULED AND NABILONE FOR 97 00:05:36,636 --> 00:05:42,075 TREATING AIDS WASTING AND WITH 98 00:05:42,141 --> 00:05:43,576 THE FARM BILL PASSED CERTAIN 99 00:05:43,643 --> 00:05:45,645 CANNABIS PRODUCTS SUCH AS HEMP 100 00:05:45,712 --> 00:05:56,222 ARE AVAILABLE AND UNSCHEDULED. 101 00:06:03,896 --> 00:06:05,898 THERE ARE SOME CHALLENGES WITH 102 00:06:05,965 --> 00:06:08,367 THE SCHEDULING OF COURSE. 103 00:06:08,434 --> 00:06:10,136 OVERSIGHT AND LICENSING FROM 104 00:06:10,203 --> 00:06:15,775 DEA, SECURITY MEASURES ARE NEED 105 00:06:15,842 --> 00:06:26,285 ED THERE'S GOOD NEWS, AND 106 00:06:29,288 --> 00:06:32,492 SERVICE WAS RECOMMENDED TO THE 107 00:06:32,558 --> 00:06:33,426 DRUG ENFORCEMENT AGENCY CANNABIS 108 00:06:33,493 --> 00:06:36,395 BE RESCHEDULED AS A SCHEDULE 3 109 00:06:36,462 --> 00:06:38,898 COMPOUND MAKING ITS WAY THROUGH 110 00:06:38,965 --> 00:06:40,366 THE DEPARTMENT OF JUSTICE AND 111 00:06:40,433 --> 00:06:40,533 DEA. 112 00:06:40,600 --> 00:06:43,770 WE'RE HOPEFUL THIS WILL HAPPEN. 113 00:06:43,836 --> 00:06:44,871 ANYTHING THAT MOVE RESEARCH 114 00:06:44,937 --> 00:06:47,373 QUICKER, FASTER, BETTER WE'RE 115 00:06:47,440 --> 00:06:51,177 ALL FOR IT AND HOPE THIS WILL 116 00:06:51,244 --> 00:06:52,311 MAKE LIFE EASIER BECAUSE WE 117 00:06:52,378 --> 00:06:57,950 DON'T YET KNOW WHAT THIS WILL 118 00:06:58,017 --> 00:07:00,153 BRING IN BRINGING RESEARCH 119 00:07:00,219 --> 00:07:05,691 QUICKER, BETTER, FASTER BUT 120 00:07:05,758 --> 00:07:07,760 WE'RE HOPEFUL. 121 00:07:07,827 --> 00:07:09,328 REGARDLESS OF THE SCHEDULE IS 122 00:07:09,395 --> 00:07:12,131 NCCIH WE'RE STILL INTERESTED IN 123 00:07:12,198 --> 00:07:15,134 THE PLANT AND COMPLEX MIXTURE OF 124 00:07:15,201 --> 00:07:25,745 MINOR CANNABINOIDS AND TURPINE 125 00:07:26,012 --> 00:07:27,747 AND WE'RE INTERESTED FOR 126 00:07:27,814 --> 00:07:30,349 THERAPEUTIC POTENTIAL AND 127 00:07:30,416 --> 00:07:32,251 PRECLINICAL RESEARCH SHOWED THE 128 00:07:32,318 --> 00:07:34,020 CANNABINOIDS TARGET SITES 129 00:07:34,086 --> 00:07:36,556 RELEVANT TO TREATMENT SUCH AS 130 00:07:36,622 --> 00:07:42,562 FOR STIMULATION AND OTHER THAT 131 00:07:42,628 --> 00:07:45,164 WILL ARE ANTIINFLAMMATORY 132 00:07:45,231 --> 00:07:48,367 PROPERTIES AND ANALGESIC AND 133 00:07:48,434 --> 00:07:48,868 ANTIPSYCHOTIC POTENTIAL 134 00:07:48,935 --> 00:07:59,145 PROPERTIES. 135 00:08:05,751 --> 00:08:12,558 WE LAUNCHED A NOSI TO STUDY THE 136 00:08:12,625 --> 00:08:14,026 ANALGESIC PROPERTIES BUT WE OPEN 137 00:08:14,093 --> 00:08:18,564 THAT UP TO OTHER INSTITUTES AT 138 00:08:18,631 --> 00:08:20,933 THE NIH AND TWO OR DELIGHT 139 00:08:21,000 --> 00:08:23,769 OTHERS SIGNED ON TO THE IN THE 140 00:08:23,836 --> 00:08:25,204 OF INTEREST INCLUDING THE 141 00:08:25,271 --> 00:08:26,038 NATIONAL CANCER INSTITUTE, 142 00:08:26,105 --> 00:08:27,206 NATIONAL EYE INSTITUTE AND 143 00:08:27,273 --> 00:08:29,008 NATIONAL INSTITUTE ON AGING AND 144 00:08:29,075 --> 00:08:30,209 THE NATIONAL INSTITUTE ON 145 00:08:30,276 --> 00:08:32,912 ALCOHOL ABUSE AND ALCOHOLISM AND 146 00:08:32,979 --> 00:08:36,349 THE NATIONAL CENTER FOR 147 00:08:36,415 --> 00:08:38,150 CRANIODENTAL FACIAL RESEARCH AND 148 00:08:38,217 --> 00:08:42,688 NIDA AND THE NATIONAL INSTITUTE 149 00:08:42,755 --> 00:08:44,223 ON NEUROLOGICAL DISEASE OF 150 00:08:44,290 --> 00:08:45,324 STROKE AND THE OFFICE OF 151 00:08:45,391 --> 00:08:49,328 RESEARCH ON WOMEN'S HEALTH. 152 00:08:49,395 --> 00:08:51,464 AND GOOD TO SEE OTHER INSTITUTES 153 00:08:51,530 --> 00:08:54,467 SEE POTENTIAL IN STUDYING 154 00:08:54,533 --> 00:08:56,702 CANNABIS FOR THE THERAPEUTIC 155 00:08:56,769 --> 00:08:59,472 BENEFITS PARTICULARLY THE MINOR 156 00:08:59,538 --> 00:09:01,007 CANNABINOIDS AND STAYING AWAY 157 00:09:01,073 --> 00:09:02,541 FROM THE MOST PSYCH ACTIVE THAT 158 00:09:02,608 --> 00:09:13,152 CAUSES DEPENDENCE AND ADDICTION. 159 00:09:19,325 --> 00:09:22,194 YOU'LL BE HEARING ABOUT INTEREST 160 00:09:22,261 --> 00:09:22,862 IN THERAPEUTIC POTENTIAL FOR 161 00:09:22,929 --> 00:09:23,996 CANNABIS AND IT'S A NICE TO SEE 162 00:09:24,063 --> 00:09:26,832 ALL THIS TAKING PLACE AT THE NIH 163 00:09:26,899 --> 00:09:28,200 NOW THAT WE'RE STARTING TO SEE 164 00:09:28,267 --> 00:09:30,436 CHANGES IN SCHEDULING AND OTHER 165 00:09:30,503 --> 00:09:33,739 ASPECTS THAT MAY MAKE RESEARCH 166 00:09:33,806 --> 00:09:35,374 EASIER ACROSS THE NIH AND 167 00:09:35,441 --> 00:09:36,542 FINALLY TO CONDITION THE EFFORT 168 00:09:36,609 --> 00:09:41,714 AND THE MOMENTUM, JUST THIS YEAR 169 00:09:41,781 --> 00:09:44,417 WE ISSUED AN RFA LOOKING TO 170 00:09:44,483 --> 00:09:47,253 SUPPORT A RESEARCH CENTER FOR 171 00:09:47,320 --> 00:09:47,853 CANNABIS AND CANNABINOID 172 00:09:47,920 --> 00:09:48,120 RESEARCH. 173 00:09:48,187 --> 00:09:50,189 THOSE APPLICATIONS CAME IN AND 174 00:09:50,256 --> 00:09:55,761 WE HAD A VERY ROBUST RESPONSE TO 175 00:09:55,828 --> 00:09:59,565 THIS RFA. 176 00:09:59,632 --> 00:10:00,232 THE APPLICATIONS WILL BE 177 00:10:00,299 --> 00:10:02,234 REVIEWED IN JULY AND WE THINK 178 00:10:02,301 --> 00:10:05,037 THIS CENTER HAS THE OPPORTUNITY 179 00:10:05,104 --> 00:10:07,773 TO FURTHER ADVANCE AND FURTHER 180 00:10:07,840 --> 00:10:09,608 THE RESEARCH THAT NIH SUPPORTS 181 00:10:09,675 --> 00:10:10,643 BY GIVING OPPORTUNITIES TO 182 00:10:10,710 --> 00:10:13,679 RESEARCHERS WHEN MAY BE OUTSIDE 183 00:10:13,746 --> 00:10:14,347 THE CANNABINOID RESEARCH FIELD 184 00:10:14,413 --> 00:10:16,148 TO GET INVOLVED AND GIVE THEM A 185 00:10:16,215 --> 00:10:18,651 HELPING HAND TO GET THE RESEARCH 186 00:10:18,718 --> 00:10:19,652 GOING IN THIS COMPLEX REGULATORY 187 00:10:19,719 --> 00:10:23,189 ENVIRONMENT. 188 00:10:23,255 --> 00:10:24,223 WITH THAT ALL STOP AND THANK YOU 189 00:10:24,290 --> 00:10:34,800 VERY MUCH FOR YOUR ATTENTION. 190 00:10:49,515 --> 00:10:52,084 >> GOOD MORNING I'M THE DIRECTOR 191 00:10:52,151 --> 00:10:52,952 OF EXTRAMURAL DIVISION AT NCCIH 192 00:10:53,019 --> 00:10:55,788 TO SEE EVERYBODY IN PERSON. 193 00:10:55,855 --> 00:11:02,695 DAVID ALREADY GAVE A SUMMARY OF 194 00:11:02,762 --> 00:11:03,763 THE HISTORY OF THE PROGRAM AND 195 00:11:03,829 --> 00:11:06,198 GO MORE GRAN YOU WU 196 00:11:06,265 --> 00:11:11,771 GO MORE GRAN YOU LULAR AND SIX S 197 00:11:11,837 --> 00:11:15,975 ARE COMPLETED AND FIVE OF THE 198 00:11:16,042 --> 00:11:18,044 R01 GOING TO COMPLETE THIS YEAR 199 00:11:18,110 --> 00:11:21,013 AND EARLY 2025. 200 00:11:21,080 --> 00:11:22,581 AND THROUGH THAT EFFORT WITH THE 201 00:11:22,648 --> 00:11:25,284 RFA AND NOSI WE ACTUALLY HAVE 202 00:11:25,351 --> 00:11:30,623 SEEN A GROWTH IN OUR RESEARCH 203 00:11:30,689 --> 00:11:34,593 PORTFOLIO 20 TO 25 GRANTS. 204 00:11:34,660 --> 00:11:36,629 IT'S A BURGEONING EFFORT AND 205 00:11:36,695 --> 00:11:37,830 WE'RE HAPPY TO SEE THIS. 206 00:11:37,897 --> 00:11:39,765 MORE EXCITING IS THE FACT 207 00:11:39,832 --> 00:11:41,634 THROUGH THE P.I. MEETING THE 208 00:11:41,700 --> 00:11:43,469 NUMBER OF COLLABORATIONS HAVE 209 00:11:43,536 --> 00:11:47,773 ALREADY STARTED BETWEEN YOU AND 210 00:11:47,840 --> 00:11:50,910 SO TODAY IT'S GOING TO BE 211 00:11:50,976 --> 00:11:53,612 INTERESTING TO HERE THOUGH IT'S 212 00:11:53,679 --> 00:11:55,314 THROUGH A DATA BLITZ FORMAT 213 00:11:55,381 --> 00:11:57,216 MEANING FIVE-MINUTE 214 00:11:57,283 --> 00:12:02,088 PRESENTATIONS THE ADVANCEMENTS 215 00:12:02,154 --> 00:12:06,525 DONE NOT ONLY IN THE 216 00:12:06,592 --> 00:12:12,598 NON-CLINICAL STUDIES OF PAIN AND 217 00:12:12,665 --> 00:12:22,942 CLINICAL ASPECT. 218 00:12:26,946 --> 00:12:28,280 THE PRESENTATIONS WILL BE SHORT, 219 00:12:28,347 --> 00:12:29,949 FIVE MINUTES EACH. 220 00:12:30,015 --> 00:12:31,750 WE'LL ASK YOU TO HOLD QUESTIONS 221 00:12:31,817 --> 00:12:34,487 TO THE END OF THE SESSION. 222 00:12:34,553 --> 00:12:35,020 THERE'LL BE THREE. 223 00:12:35,087 --> 00:12:37,623 TWO FOCUSSED ON THE NON-CLINICAL 224 00:12:37,690 --> 00:12:39,758 ASPECT AND ONE ON THE CLINICAL 225 00:12:39,825 --> 00:12:41,127 ASPECT AND THEN OPEN IT UP FOR 226 00:12:41,193 --> 00:12:44,330 QUESTION AFTER THE END OF THE 227 00:12:44,396 --> 00:12:44,563 SESSION. 228 00:12:44,630 --> 00:12:45,764 SO WITHOUT FURTHER ADO, I'M 229 00:12:45,831 --> 00:12:51,237 GOING TO TURN IT OVER TO INNA 230 00:12:51,303 --> 00:12:52,371 AND LOOK FORWARD TO HEARING THE 231 00:12:52,438 --> 00:12:52,705 PRESENTATIONS. 232 00:12:52,771 --> 00:13:03,115 THANK YOU VERY MUCH. 233 00:13:10,189 --> 00:13:16,262 >> THANK YOU, DAVID AND EMMELINE 234 00:13:16,328 --> 00:13:22,301 FOR YOUR LEADERSHIP AND FOR THE 235 00:13:22,368 --> 00:13:27,973 NCCIH DIRECTOR. 236 00:13:28,040 --> 00:13:31,277 WE'RE UNDER THIS BIG UMBRELLA 237 00:13:31,343 --> 00:13:33,979 AND NOW WE'LL MOVE TO OUR FIRST 238 00:13:34,046 --> 00:13:34,213 SESSION. 239 00:13:34,280 --> 00:13:36,148 THE FIRST SESSION WILL BE THE 240 00:13:36,215 --> 00:13:42,288 FIRST PORTION OF THE MEETING. 241 00:13:42,354 --> 00:13:43,956 WE'LL HAVE 15 PRINCIPAL 242 00:13:44,023 --> 00:13:45,324 INVESTIGATORS OF THE 243 00:13:45,391 --> 00:13:47,293 NON-CLINICAL STUDIES ON 244 00:13:47,359 --> 00:13:50,129 CANNABINOIDS AND PAIN AND EACH 245 00:13:50,196 --> 00:13:52,798 WILL PRESENT A FIVE-MINUTE 246 00:13:52,865 --> 00:13:54,300 PRESENTATION AND THIS WILL BE 247 00:13:54,366 --> 00:13:55,768 PRESENTATION ON STUDY DESIGN, 248 00:13:55,834 --> 00:13:57,603 MAGIC FINDINGS AND NEXT STEPS 249 00:13:57,670 --> 00:13:59,104 AND NEXT STEPS IS IMPORTANT AND 250 00:13:59,171 --> 00:14:01,707 WE WILL BE TALKING ABOUT IT 251 00:14:01,774 --> 00:14:05,811 AFTER THE THOUGHT SESSION OF THE 252 00:14:05,878 --> 00:14:08,514 P.I.s WE'LL HAVE A BRIEF Q&A 253 00:14:08,581 --> 00:14:12,017 AFTER EIGHT PRESENTATIONS AND 254 00:14:12,084 --> 00:14:16,222 BRIEF Q&A AFTER NEXT SET OF 255 00:14:16,288 --> 00:14:18,657 QUESTIONS THAT CAN'T WAIT. 256 00:14:18,724 --> 00:14:21,260 I'LL BE INTRODUCING THE SPEAKER 257 00:14:21,327 --> 00:14:22,828 ONLY BY THEIR NAME EACH WILL 258 00:14:22,895 --> 00:14:25,097 HAVE FIVE MINUTES WITH A 259 00:14:25,164 --> 00:14:26,599 THREE-MINUTE VERBAL WARNING AND 260 00:14:26,665 --> 00:14:31,036 WHEN THE TIME IS UP ANOTHER 261 00:14:31,103 --> 00:14:32,238 VERBAL WARNING. 262 00:14:32,304 --> 00:14:38,744 WITH THIS, I'M INVITING SURGEON 263 00:14:38,811 --> 00:14:43,749 WARD OF TEMPLE UNIVERSITY TO 264 00:14:43,816 --> 00:14:54,293 PRESENT ON THE HOUSE MODEL. 265 00:14:58,497 --> 00:14:58,964 >> THANK YOU VERY MUCH. 266 00:14:59,031 --> 00:15:02,868 YOU KNOW I CAN HARDLY INTRODUCE 267 00:15:02,935 --> 00:15:04,503 MY NAME IN FIVE MINUTES I'M NOT 268 00:15:04,570 --> 00:15:09,241 ONE ON BREVITY BUT I'LL TRY 269 00:15:09,308 --> 00:15:09,441 HARD. 270 00:15:09,508 --> 00:15:12,711 OUR PROJECT FUNDED THROUGH THE 271 00:15:12,778 --> 00:15:18,817 RFA WAS ENTITLED ANALGESIC 272 00:15:18,884 --> 00:15:29,395 EFFICACY OF CANNABINOIDS AND 273 00:15:30,863 --> 00:15:36,969 TURPENES I'VE BEEN STUDYING THE 274 00:15:37,036 --> 00:15:41,573 NEURALOPATHY AND WE EXTENDED OUR 275 00:15:41,640 --> 00:15:42,574 FINDING OF THE BEHAVIORAL 276 00:15:42,641 --> 00:15:47,579 FINDINGS OF EFFECTS OF NEURAL 277 00:15:47,646 --> 00:15:51,750 PATHIC PANEL TO OTHER 278 00:15:51,817 --> 00:15:55,721 CANNABINOIDS AND TURPENES LIKE 279 00:15:55,788 --> 00:15:56,655 MANY SITTING IN THE AUDIENCE 280 00:15:56,722 --> 00:15:59,124 THERE'S THE IDEA OF THE ENTERAGE 281 00:15:59,191 --> 00:15:59,358 EFFECT. 282 00:15:59,425 --> 00:16:00,559 ONE OF THE FIRST EXPERIMENTS 283 00:16:00,626 --> 00:16:02,594 THAT WE CONDUCTED IN THE 284 00:16:02,661 --> 00:16:03,796 LABORATORY WAS TO LOOK AT 285 00:16:03,862 --> 00:16:08,133 WHETHER THE COMBINED EFFECTS OF 286 00:16:08,200 --> 00:16:12,771 CBD AND DELTA 9THC PRODUCE 287 00:16:12,838 --> 00:16:17,142 EFFECTS IN THE PAIN MODEL AND 288 00:16:17,209 --> 00:16:21,914 FOUND PROFOUND SYNERGISTIC 289 00:16:21,980 --> 00:16:26,285 EFFECTS AND WE EXTENDED THE 290 00:16:26,352 --> 00:16:29,488 RESEARCH INTO POTENTIAL 291 00:16:29,555 --> 00:16:31,156 INTERACTIVE EFFECTS BETWEEN 292 00:16:31,223 --> 00:16:35,494 OTHER MINOR CANNABINOIDS AND 293 00:16:35,561 --> 00:16:36,562 TURPENES AND THE ADDITIONAL GOAL 294 00:16:36,628 --> 00:16:41,567 WAS TO MOVE THE BEYOND THE 295 00:16:41,633 --> 00:16:45,070 NEUROPATHIC PAIN TO OTHER MODELS 296 00:16:45,137 --> 00:16:46,572 AND HAVE A RAT MODEL OF 297 00:16:46,638 --> 00:16:48,741 INFLAMMATORY DENTAL PAIN. 298 00:16:48,807 --> 00:16:50,509 THIS IS MY DATA SLIDE SHOWING 299 00:16:50,576 --> 00:16:52,111 YOU SOME OF THE HIGHLIGHTS OF 300 00:16:52,177 --> 00:16:54,747 THE WORK THAT HAS BEEN CONDUCTED 301 00:16:54,813 --> 00:16:56,582 UNDER THE R01. 302 00:16:56,648 --> 00:16:58,584 THE FIRST THREE ARE 303 00:16:58,650 --> 00:16:58,917 PUBLICATIONS. 304 00:16:58,984 --> 00:16:59,752 I'VE LISTED THE PUBLICATIONS 305 00:16:59,818 --> 00:17:09,928 HERE. 306 00:17:27,880 --> 00:17:31,483 WE SPENT TIME CATEGORIZING CBG 307 00:17:31,550 --> 00:17:34,787 AND WE FIND NUANCED EFFECTS IN 308 00:17:34,853 --> 00:17:36,188 THE MECHANICAL SENSITIVITY. 309 00:17:36,255 --> 00:17:38,557 WE ONLY GET SIGNIFICANT EFFECTS 310 00:17:38,624 --> 00:17:39,725 UNDER SPECIFIC DOSING 311 00:17:39,792 --> 00:17:41,026 CONDITIONS. 312 00:17:41,093 --> 00:17:46,365 WHEN WE LOOK AT THOSE EFFECTS IN 313 00:17:46,432 --> 00:17:48,767 COMBINATION WITH CBD WE FIND 314 00:17:48,834 --> 00:17:51,036 CERTAIN SITUATIONS WHERE WE 315 00:17:51,103 --> 00:17:57,876 CONFINED CBG WITH CBD PRODUCE 316 00:17:57,943 --> 00:18:00,045 OTHER EFFECTS AND FIND SUB 317 00:18:00,112 --> 00:18:01,079 ADDITIVE EFFECTS AND I DIRECT 318 00:18:01,146 --> 00:18:03,449 YOU TO THE MANUSCRIPT IF YOU'RE 319 00:18:03,515 --> 00:18:05,484 INTERESTED IN HEARING ABOUT MY 320 00:18:05,551 --> 00:18:07,753 HYPOTHESIS THAT DIFFERENT 321 00:18:07,820 --> 00:18:14,893 RECEPTOR MECHANISMS MAY UNDERLIE 322 00:18:14,960 --> 00:18:19,765 THE SYNERGISTIC EFFECTS OF CBG 323 00:18:19,832 --> 00:18:25,571 AND C.D.BD AND THE OTHER IS THE 324 00:18:25,637 --> 00:18:27,773 SEX, TIME AND SITE SPECIFIC AND 325 00:18:27,840 --> 00:18:29,341 PREVENTED BY CBG ADMINISTRATION. 326 00:18:29,408 --> 00:18:33,479 THIS GAME A STUDY THAT REALLY 327 00:18:33,545 --> 00:18:36,081 DOVE DOWN INTO THE 328 00:18:36,148 --> 00:18:36,915 NEUROINFLAMMATORY SEX 329 00:18:36,982 --> 00:18:38,050 DIFFERENCES IN THE MOUSE MODEL. 330 00:18:38,116 --> 00:18:41,353 AND SO BEFORE WE CAN ADDRESS 331 00:18:41,420 --> 00:18:42,821 BEFORE THERE'S SEX DIFFERENCES 332 00:18:42,888 --> 00:18:43,822 WITH PHYTO CANNABINOIDS IN THE 333 00:18:43,889 --> 00:18:45,123 ASSAY WE NEED TO UNDERSTAND WHAT 334 00:18:45,190 --> 00:18:47,926 THE SEX DIFFERENCES ARE IN THE 335 00:18:47,993 --> 00:18:49,728 MAIN POLLED ITSELF. 336 00:18:49,795 --> 00:18:54,800 AND WE FOUND THERE ARE SEX 337 00:18:54,867 --> 00:19:02,674 DIFFERENCES AFTER OXALIPLATIN 338 00:19:02,741 --> 00:19:11,717 INVESTIGATION AND WHICH ANOLITES 339 00:19:11,783 --> 00:19:14,753 YOU'RE LOOKING AT AND THE THIRD 340 00:19:14,820 --> 00:19:17,923 IS THE DENTAL PAIN MODEL. 341 00:19:17,990 --> 00:19:21,693 AND WE ANESTHETIZED THE RATS AND 342 00:19:21,760 --> 00:19:24,396 I HAD BRAVE STUDENTS WHO DRILLED 343 00:19:24,463 --> 00:19:28,834 A WHOLE IN THE MOLAR OF THE RAT 344 00:19:28,901 --> 00:19:34,172 AND MEASURE THE SENSITIVITY AND 345 00:19:34,239 --> 00:19:39,244 TREAT THESE RATS WITH PHYTO 346 00:19:39,311 --> 00:19:47,052 CANNABINOIDS AND TERPENES AND WE 347 00:19:47,119 --> 00:19:52,024 GET THE PREVENTION OF NEURAL IF 348 00:19:52,090 --> 00:19:55,694 INFLAMMATION AND SENSITIVITY 349 00:19:55,761 --> 00:19:57,563 WHEN WE TREAT THEM AND ANOTHER 350 00:19:57,629 --> 00:20:03,468 STUDY IS ANTI-INFLAMMATORY 351 00:20:03,535 --> 00:20:10,275 EFFECTS OF BETA CARYOPHYILENE 352 00:20:10,342 --> 00:20:12,811 AND EFFECTS OF BCB THAT LOOK 353 00:20:12,878 --> 00:20:18,650 MORE ROBUST IN OUR HANDS THAN 354 00:20:18,717 --> 00:20:29,261 CBD AND SYNERGISTIC INTERACTION. 355 00:20:53,051 --> 00:20:59,725 LET'S DEFINE THE MECHANISMS OF 356 00:20:59,791 --> 00:21:04,329 ACTION OF ARTHRITIS AND CBD. 357 00:21:04,396 --> 00:21:05,998 >> GOOD MORNING, EVERYONE. 358 00:21:06,064 --> 00:21:07,966 ARE YOU ABLE TO SEE MY SLIDES? 359 00:21:08,033 --> 00:21:08,200 >> YES. 360 00:21:08,266 --> 00:21:10,636 >> GREAT. 361 00:21:10,702 --> 00:21:15,741 THE GOAL OF OUR STUDY IS TO 362 00:21:15,807 --> 00:21:22,514 IDENTIFY THE MECHANISM OF ACTION 363 00:21:22,581 --> 00:21:25,784 FORECBD AND CHRONIC OA AND WE 364 00:21:25,851 --> 00:21:30,422 USE A STUDY TO IDENTIFY NEURAL 365 00:21:30,489 --> 00:21:33,425 CHEMICAL ALTERATIONS INDUCED BY 366 00:21:33,492 --> 00:21:36,695 CHRONIC PAIN IN THE OA MOUSE 367 00:21:36,762 --> 00:21:39,765 MODEL AND LOOK AT THE CBD 368 00:21:39,831 --> 00:21:46,638 MODULATION AND CHANGES WITH THE 369 00:21:46,705 --> 00:21:54,813 ANALGESIC AND AN-XIOLYTIC YOU, 370 00:21:54,880 --> 00:21:56,148 ANTI-INFLAMMATORY PROPERTIES 371 00:21:56,214 --> 00:22:06,692 WITH ANTAGONIST COMBINATION. 372 00:22:25,477 --> 00:22:30,816 IN THIS STUDY WE CONCENTRATE ON 373 00:22:30,882 --> 00:22:35,153 THE TARGETS AND ALSO THE TSP TAR 374 00:22:35,220 --> 00:22:36,221 GET BECAUSE THEY'RE VERY MUCH 375 00:22:36,288 --> 00:22:46,765 RELEVANT TO PAIN MANAGEMENT. 376 00:22:47,899 --> 00:22:50,102 CBD BINDS TO THE RECEPTOR AND 377 00:22:50,168 --> 00:22:53,004 DEMONSTRATED IN THE IMAGING 378 00:22:53,071 --> 00:22:55,774 STUDY THIS IS AT BASELINE THE 379 00:22:55,841 --> 00:22:57,309 REGISTRATION AND YOU CAN SEE 380 00:22:57,375 --> 00:23:02,614 HIGH UPTAKE OF THE TRACER BUT IN 381 00:23:02,681 --> 00:23:08,587 THE ANIMAL TREATED SIGNIFICANT 382 00:23:08,653 --> 00:23:12,858 REDUCTION IN THE BRAIN AND THIS 383 00:23:12,924 --> 00:23:17,329 SUGGESTS THE CBD BLOCK THE 384 00:23:17,395 --> 00:23:19,598 UPTAKE CONSISTENT WITH THE FACT 385 00:23:19,664 --> 00:23:24,836 CBD BINDS AND FOR THE FIRST TIME 386 00:23:24,903 --> 00:23:27,739 WE DEMONSTRATED ON THE IMAGING. 387 00:23:27,806 --> 00:23:38,316 AND NEXT UP IS TO CREATE AND 388 00:23:45,891 --> 00:23:51,429 WE'RE SHOWING WE CREATE THE OA 389 00:23:51,496 --> 00:23:55,767 MODEL AND THE INDUCTION WE FOUND 390 00:23:55,834 --> 00:23:59,137 THE TRACER UPTAKE IN THE MODEL 391 00:23:59,204 --> 00:24:03,108 WAS REDUCED AND SHOWN IN THIS 392 00:24:03,175 --> 00:24:05,811 BAR GRAPH SHOWS THE BRAIN REGION 393 00:24:05,877 --> 00:24:08,814 AT BASELINE, HIGH UPTAKE AND 394 00:24:08,880 --> 00:24:13,084 AFTER OA REDUCED AND THE KNOWN 395 00:24:13,151 --> 00:24:15,587 EFFECT WITH THE TREATMENT IN 396 00:24:15,654 --> 00:24:17,355 BEIGE COLOR AND WITH CBD YOU CAN 397 00:24:17,422 --> 00:24:19,925 SEE THE RESTORATION OF THE TRACE 398 00:24:19,991 --> 00:24:23,762 UPTAKE WAS OBSERVED. 399 00:24:23,829 --> 00:24:33,004 THIS IS CONSISTENT WITH CBD AND 400 00:24:33,371 --> 00:24:36,074 ANDIE 401 00:24:40,178 --> 00:24:50,622 THE ANXIOLYTIC ON DAY 15 AND 402 00:24:58,763 --> 00:25:02,667 HERE THE RATIO REMEMBER INDICATE 403 00:25:02,734 --> 00:25:03,201 THE CBD TREATMENT REDUCE 404 00:25:03,268 --> 00:25:13,511 INFLAMMATION. 405 00:25:22,621 --> 00:25:26,258 AND WE LOOKED AT BASELINE AND 406 00:25:26,324 --> 00:25:30,862 AFTER DRUG TREATMENT AND 407 00:25:30,929 --> 00:25:41,473 BASICALLY THE SENSITIVITY WITH 408 00:25:42,974 --> 00:25:48,480 THE CBD AND FOR THE DARK WE 409 00:25:48,546 --> 00:25:51,449 SHOWED SHE HIGHER ANXIETY AS THE 410 00:25:51,516 --> 00:25:57,389 OA STAGE AND RECOVERS AFTER 411 00:25:57,455 --> 00:25:59,758 DAILY CBD. 412 00:25:59,824 --> 00:26:04,896 AND WE FOUND A DECREASE IN THE 413 00:26:04,963 --> 00:26:09,701 MOTOR ACTIVITY AT OA STAGE AND 414 00:26:09,768 --> 00:26:11,703 RECOVERS IMPROVES WITH CBD. 415 00:26:11,770 --> 00:26:15,740 INTERESTING WE DO SEE THE GENDER 416 00:26:15,807 --> 00:26:17,175 EFFECT SIGNIFICANCE DIFFERENCE 417 00:26:17,242 --> 00:26:21,880 FOR MALE ONLY IN ALL ASPECTS AND 418 00:26:21,947 --> 00:26:28,887 OA WAS AT BASELINE AND OA VERSUS 419 00:26:28,954 --> 00:26:31,389 CONTROL AND CBD. 420 00:26:31,456 --> 00:26:35,360 UNFORTUNATELY FOR THE AGONIST, 421 00:26:35,427 --> 00:26:36,161 ANTAGONIST COMBINATION TREATMENT 422 00:26:36,227 --> 00:26:39,331 STUDY THE DIFFERENCE WERE NOT 423 00:26:39,397 --> 00:26:39,764 OBSERVED. 424 00:26:39,831 --> 00:26:47,305 THIS MAY BE DUE TO THE SMALLER 425 00:26:47,372 --> 00:26:51,743 SAMPLE SIZE OF THE DOSE WE USE 426 00:26:51,810 --> 00:26:54,112 NOT OPTIMAL. 427 00:26:54,179 --> 00:26:55,780 OVERALL WE FINE TUNE THE 428 00:26:55,847 --> 00:27:00,285 MECHANISTIC STUDY IN HUMAN FOR 429 00:27:00,352 --> 00:27:04,055 EXAMPLE IN 5HT1A MODULATION AND 430 00:27:04,122 --> 00:27:07,292 INFLAMMATORY EFFECTS IN HUMAN 431 00:27:07,359 --> 00:27:08,760 BEFORE AND AFTER CBD TREATMENT. 432 00:27:08,827 --> 00:27:11,763 THAT'S MY FIVE MINUTES. 433 00:27:11,830 --> 00:27:15,066 THANK YOU VERY MUCH FOR YOUR 434 00:27:15,133 --> 00:27:17,235 ATTENTION. 435 00:27:17,302 --> 00:27:20,839 >> THANK YOU, DR. DING. 436 00:27:20,905 --> 00:27:24,843 THE NEXT SPEAKER IS PRESENTING 437 00:27:24,909 --> 00:27:30,148 ON SYNTHETIC BIOLOGY FOR THE 438 00:27:30,215 --> 00:27:31,149 MANIPULATION OF PAIN. 439 00:27:31,216 --> 00:27:33,585 >> THANKS TO EVERYONE FOR THE 440 00:27:33,651 --> 00:27:35,086 OPPORTUNITY TO ADDRESS YOU AND 441 00:27:35,153 --> 00:27:38,656 FOR THIS PROGRAM FOR ALLOWING IN 442 00:27:38,723 --> 00:27:39,557 SYNTHETIC BIOLOGY EFFORTS IN 443 00:27:39,624 --> 00:27:40,592 CANNABINOID RESEARCH. 444 00:27:40,658 --> 00:27:44,629 OUR ONGOING GOAL HAS BEEN TO 445 00:27:44,696 --> 00:27:47,032 ESSENTIALLY DISSECT HUMAN NEURAL 446 00:27:47,098 --> 00:27:50,101 RESPONSES BY MOVING INTO THE 447 00:27:50,168 --> 00:27:52,103 RECEPTORS OR DIFFERENT COMPOUNDS 448 00:27:52,170 --> 00:27:52,804 IN THE YEAST. 449 00:27:52,871 --> 00:27:54,839 IN PARTICULAR UNDER THIS PROGRAM 450 00:27:54,906 --> 00:28:00,845 WE WERE ABLE TO MOVE CD1R AND 2R 451 00:28:00,912 --> 00:28:05,250 IN THE YEAST AND HAVE OTHER 452 00:28:05,316 --> 00:28:06,951 OPIOID RECEPTOR AND OVER ALL 453 00:28:07,018 --> 00:28:10,121 IT'S BEEN A REAL ABILITY -- THE 454 00:28:10,188 --> 00:28:13,825 FUNDING HAS ALLOWED US TO MOVE 455 00:28:13,892 --> 00:28:17,695 FORWARD IN PUTTING INDIVIDUAL 456 00:28:17,762 --> 00:28:18,329 RECEPTORS IN YEAST AND GETTING 457 00:28:18,396 --> 00:28:25,870 FUNCTION OUT. 458 00:28:25,937 --> 00:28:33,578 AND THE OPOTHE OSIS IS WE'RE 459 00:28:33,645 --> 00:28:37,148 ABLE TO DISSECT HUNDREDS OF 460 00:28:37,215 --> 00:28:38,783 CANNABINOIDS AND THE GRANT IS 461 00:28:38,850 --> 00:28:40,718 EXPIRED AND WE NO LONGER HAVE 462 00:28:40,785 --> 00:28:44,956 FUNDS FOR THIS AND WHAT WE'VE 463 00:28:45,023 --> 00:28:47,759 DONE SINCE THE EXPIRATION OF THE 464 00:28:47,826 --> 00:28:51,229 FUND IS IT FOR MANY YEAST 465 00:28:51,296 --> 00:28:52,063 RECEPTORS FOR INDIVIDUAL 466 00:28:52,130 --> 00:28:54,766 COMPOUNDS MIMIC THE MAMMALIAN 467 00:28:54,833 --> 00:28:58,570 CELLS AND HAVE SHOWN FOR CB1R 468 00:28:58,636 --> 00:29:01,840 AND 2R YEAST OUR RESULTS IN 469 00:29:01,906 --> 00:29:04,109 YEAST ARE SIMILAR TO THOSE IN 470 00:29:04,175 --> 00:29:05,643 MAMMALIAN CELLS AND ALLOWED US 471 00:29:05,710 --> 00:29:07,445 TO GET THE PAPERS OUT WITH 472 00:29:07,512 --> 00:29:09,147 CONFIRMATION IT WILL BE 473 00:29:09,214 --> 00:29:09,814 PUBLISHED IN THE INTERNATIONAL 474 00:29:09,881 --> 00:29:10,949 JOURNAL OF MOLECULAR SCIENCES 475 00:29:11,015 --> 00:29:13,051 AND THIS WAS ALL LARGELY WORK 476 00:29:13,118 --> 00:29:16,221 DONE BY LIZ GARNER NOW A FACULTY 477 00:29:16,287 --> 00:29:21,726 MEMBER IN HER OWN RIGHT. 478 00:29:21,793 --> 00:29:23,361 WHAT I'D LIKE TO TALK TO YOU 479 00:29:23,428 --> 00:29:26,297 ABOUT BRIEFLY IS ONGOING WORK 480 00:29:26,364 --> 00:29:28,633 WHERE WE'RE USING MACHINE 481 00:29:28,700 --> 00:29:29,968 LEARNING TO UNDERSTAND HOW 482 00:29:30,034 --> 00:29:31,569 CANNABINOIDS RELATE TO THEIR 483 00:29:31,636 --> 00:29:31,836 RECEPTORS. 484 00:29:31,903 --> 00:29:33,104 THE DATABASE FOR THIS IS 485 00:29:33,171 --> 00:29:35,840 ESSENTIALLY PUB MED AND ALL THE 486 00:29:35,907 --> 00:29:40,945 PATENT LITERATURE WHERE IN A 487 00:29:41,012 --> 00:29:46,951 VERY HIGH LEVEL WAY WE CAN TAKE 488 00:29:47,018 --> 00:29:49,621 THE SIGNATURES OF COMPOUNDS LIKE 489 00:29:49,687 --> 00:29:54,025 A SENTENCE AND CORRELATE THOSE 490 00:29:54,092 --> 00:29:57,562 WITH ENGLISH WORDS AND LEARN 491 00:29:57,629 --> 00:29:59,230 FROM HUMAN UNDERSTANDING WHAT A 492 00:29:59,297 --> 00:30:01,733 CANNABINOID IS AND CAN LAY THESE 493 00:30:01,799 --> 00:30:03,668 OUT IN GIGANTIC CORRELATIONS 494 00:30:03,735 --> 00:30:05,170 BETWEEN WORD SPACE SO TO SPEAK 495 00:30:05,236 --> 00:30:06,604 AND CHEMISTRY SPACE AND BECAUSE 496 00:30:06,671 --> 00:30:08,706 OF THAT, WE'RE BECOMING QUITE 497 00:30:08,773 --> 00:30:10,909 CONFIDENT IN OUR ABILITY TO 498 00:30:10,975 --> 00:30:16,581 BOTH, A, PREDICT CANNABINOIDS 499 00:30:16,648 --> 00:30:18,550 AND SOME WORK ON THE HORIZON 500 00:30:18,616 --> 00:30:19,384 WE'RE EXCITED ABOUT IS BEING 501 00:30:19,450 --> 00:30:21,953 ABLE TO DRAW OUT OF TO THE 502 00:30:22,020 --> 00:30:24,856 ENTIRE DATABASE OF CHEMISTRY THE 503 00:30:24,923 --> 00:30:28,326 COMPOUNDS THAT MAY ACT ON CB1R 504 00:30:28,393 --> 00:30:33,064 OR 2R OR FAVOR CB1 OVER CB2 AND 505 00:30:33,131 --> 00:30:33,331 SO FORTH. 506 00:30:33,398 --> 00:30:34,566 AND THAT'S ESSENTIALLY WHAT I 507 00:30:34,632 --> 00:30:36,134 JUST SAID. 508 00:30:36,201 --> 00:30:39,270 BECAUSE WE NOW HAVE YEAST 509 00:30:39,337 --> 00:30:41,472 STRAINS WE CAN TEST ON MACHINE 510 00:30:41,539 --> 00:30:43,741 LEARNING PREDICTION WE CAN 511 00:30:43,808 --> 00:30:45,009 IDENTIFY THE COMPOUNDS ARE IN 512 00:30:45,076 --> 00:30:47,111 FACT CANNABINOIDS AND CAN 513 00:30:47,178 --> 00:30:48,880 IDENTIFY NEW COMPOUNDS USING 514 00:30:48,947 --> 00:30:53,651 MACHINE LEARNING METHODS AND 515 00:30:53,718 --> 00:30:56,854 NEW PHENOTYPES AND LIGANDS AND 516 00:30:56,921 --> 00:30:59,357 GO FROM CHEMISTRY TO POTENTIAL 517 00:30:59,424 --> 00:31:00,892 PHENOTYPES WITH RECEPTORS AND 518 00:31:00,959 --> 00:31:01,993 FROM THERE TO POTENTIAL 519 00:31:02,060 --> 00:31:03,161 PHENOTYPES IN HUMAN SYSTEMS 520 00:31:03,228 --> 00:31:03,461 THEMSELVES. 521 00:31:03,528 --> 00:31:06,130 WITH THAT, I'LL TURN IT OVER TO 522 00:31:06,197 --> 00:31:06,531 THE NEXT SPEAKER. 523 00:31:06,598 --> 00:31:16,674 THANK YOU FOR THE OPPORTUNITY. 524 00:31:16,741 --> 00:31:18,876 >> NOW THE NEXT SPEAKER AND LAST 525 00:31:18,943 --> 00:31:21,246 SPEAK ON THIS PORTION IS 526 00:31:21,312 --> 00:31:25,683 DR. CHUI FROM HARVARD MEDICAL 527 00:31:25,750 --> 00:31:30,488 SCHOOL ON ANALGESIC EFFECTS OF 528 00:31:30,555 --> 00:31:30,888 TERPENES. 529 00:31:30,955 --> 00:31:34,926 >> THANK YOU VERY MUCH. 530 00:31:34,993 --> 00:31:37,695 I WANT TO INTRODUCE THIS WAS A 531 00:31:37,762 --> 00:31:42,166 JOINT PROJECT FUNDED BY AN RF21 532 00:31:42,233 --> 00:31:47,138 BY DR. QUAVE AND MYSELF AT 533 00:31:47,205 --> 00:31:50,208 HARVARD MEDICAL SCHOOL AND 534 00:31:50,275 --> 00:32:00,985 DR. QUAVE IS AN ETHOBOTONIST AN 535 00:32:12,864 --> 00:32:17,168 HOPS WE USE COMMERCIALLY TO MAKE 536 00:32:17,235 --> 00:32:23,775 BEER BUT HAS RICHNESS IN 537 00:32:23,841 --> 00:32:34,252 TERPENES AND TERPINOIDS. 538 00:32:46,664 --> 00:32:48,766 AND THIS MAY AFFECT SENSORY 539 00:32:48,833 --> 00:32:51,035 NEURONS TO MEDIATE PAIN AND CAN 540 00:32:51,102 --> 00:32:55,506 WE CREATE FORMULATIONS RICH IN 541 00:32:55,573 --> 00:32:57,709 TERPENE COMPOUNDS AND TEST 542 00:32:57,775 --> 00:33:00,878 MODULATION OF SEE IF THEY HAVE 543 00:33:00,945 --> 00:33:03,314 DIRECT EFFECTS TO MODULATE PAIN 544 00:33:03,381 --> 00:33:13,591 PRODUCTION. 545 00:33:22,533 --> 00:33:23,401 SORRY, I THINK PARTS OF THE 546 00:33:23,468 --> 00:33:25,370 SLIDE ARE CUT OFF BUT I'LL 547 00:33:25,436 --> 00:33:30,508 SUMMARIZE THE DATA WE FOUND. 548 00:33:34,379 --> 00:33:40,518 SO, FIRST WE USED SIX DIFFERENT 549 00:33:40,585 --> 00:33:42,887 DEFINITIONS AND THESE HOPS WERE 550 00:33:42,954 --> 00:33:45,490 SUBJECT TO MASS SPECTOMETRY AND 551 00:33:45,556 --> 00:33:47,525 THIS IS THE CHEMICAL ANALYSIS 552 00:33:47,592 --> 00:33:53,664 DR. QUAVE CONDUCTED AND USED THE 553 00:33:53,731 --> 00:33:58,970 THREE EXTRACTS MOST DISTINCT IN 554 00:33:59,036 --> 00:34:01,506 NATURE AND THE COMPOUNDS THAT 555 00:34:01,572 --> 00:34:05,910 DEFINES THEM THE MOST AND THEN 556 00:34:05,977 --> 00:34:12,884 WE DR. QUAVE FORM 4R5I9ED A WAY 557 00:34:12,950 --> 00:34:23,494 OF APPLIED THIS AND TESTED THEM 558 00:34:24,328 --> 00:34:26,264 ON DIFFERENT ASSAYS AND HAD THE 559 00:34:26,330 --> 00:34:28,933 BIGGEST EFFECT ON HEAT 560 00:34:29,000 --> 00:34:29,233 SENSITIVITY. 561 00:34:29,300 --> 00:34:33,371 ON HOT PLATE ASSAY YOU CAN SEE 562 00:34:33,438 --> 00:34:37,575 IF YOU COMPARE VEHICLE TO CBD AS 563 00:34:37,642 --> 00:34:39,343 A COMPARISON ALL THREE EXTRACTS 564 00:34:39,410 --> 00:34:42,647 HAD SIMILAR EFFICACY IN BLOCKING 565 00:34:42,713 --> 00:34:45,416 HEAT PAIN AT THE 40, 52 DEGREES 566 00:34:45,483 --> 00:34:48,886 AND THERE'S SOME SEX 567 00:34:48,953 --> 00:34:49,854 DEPENDENCIES. 568 00:34:49,921 --> 00:34:51,322 FEMALES HAVE A GREATER WITH 569 00:34:51,389 --> 00:34:53,424 ABILITY TO BE SILENCED IN TERMS 570 00:34:53,491 --> 00:35:03,701 OF EXTRACTS. 571 00:35:07,672 --> 00:35:18,149 OTHER EFFECTS AND MYRCENE AND 572 00:35:19,884 --> 00:35:23,754 HUMULENE EFFECTS DON'T HAVE 573 00:35:23,821 --> 00:35:25,656 MECHANICO THRESHOLDS THERE MAY 574 00:35:25,723 --> 00:35:30,895 BE SOME SPECIFICITY OF THE HOPS 575 00:35:30,962 --> 00:35:36,934 AND TERPENES AND IT MAY MEDIATE 576 00:35:37,001 --> 00:35:47,078 NOXIOUS HEAT SO, JUST IT'S 577 00:35:47,144 --> 00:35:49,247 INTERESTING TO THINK ABOUT OTHER 578 00:35:49,313 --> 00:35:50,948 RELATED SPECIES WHICH 579 00:35:51,015 --> 00:35:55,119 DR. SHURTLEFF MENTIONED ARE NOT 580 00:35:55,186 --> 00:35:59,323 SCHEDULED PLANT SPECIES AS 581 00:35:59,390 --> 00:36:03,961 POTENTIAL SOURCES OF ANALGESIC 582 00:36:04,028 --> 00:36:07,832 CANNABINOIDS OR TERPENES AND 583 00:36:07,899 --> 00:36:11,836 DEFINE MECHANISMS AND DR. QUAVE 584 00:36:11,903 --> 00:36:14,038 SAID THE SYNERGY OF MANY OF THE 585 00:36:14,105 --> 00:36:15,573 COMPOUNDS TOGETHER COULD BE MORE 586 00:36:15,640 --> 00:36:18,609 EFFECTIVE THAN JUST A SINGLE 587 00:36:18,676 --> 00:36:18,876 ONE. 588 00:36:18,943 --> 00:36:21,712 ALSO THINKING ABOUT THAT. 589 00:36:21,779 --> 00:36:24,015 FOR MANY ANCIENT CULTURES THEY 590 00:36:24,081 --> 00:36:28,386 TAKE THESE EXTRACTS AND 591 00:36:28,452 --> 00:36:31,389 UNDERSTANDING HOW THEY WORK 592 00:36:31,455 --> 00:36:35,059 TOGETHER AND MYRCENE MAY HAVE 593 00:36:35,126 --> 00:36:37,428 THE BIGGEST EFFECT AND MAY ACT 594 00:36:37,495 --> 00:36:41,866 ON THE NEURONS. 595 00:36:41,933 --> 00:36:43,868 WE SEE THAT IN VITRO AND CALCIUM 596 00:36:43,935 --> 00:36:48,339 IMAGING ASSAYS AND THINKING 597 00:36:48,406 --> 00:36:50,508 ABOUT HOPS AND OTHER PLANT AS A 598 00:36:50,575 --> 00:37:00,952 SOURCE OF ANALGESICS. 599 00:37:11,228 --> 00:37:13,931 >> THANK YOU, NOW WE'LL PRESENT 600 00:37:13,998 --> 00:37:15,733 ON SYSTEMATIC INVESTIGATION OF 601 00:37:15,800 --> 00:37:19,737 RARE CANNABINOIDS WITH PAIN 602 00:37:19,804 --> 00:37:21,339 RECEPTORS BY DR. DAS. 603 00:37:21,405 --> 00:37:31,916 >> IT'S NICE TO SEE EVERYBODY. 604 00:37:34,652 --> 00:37:41,092 WE WANTED TO DO A METABOLISM AND 605 00:37:41,158 --> 00:37:42,893 MINOR CANNABINOIDS ARE NOT 606 00:37:42,960 --> 00:37:47,031 REALLY MINOR AS YOU CAN SEE FROM 607 00:37:47,098 --> 00:37:54,171 THE LCMS PRESENTATION THESE ARE 608 00:37:54,238 --> 00:38:03,481 IN THE CANNABIS EXTRACT AND LOOK 609 00:38:03,547 --> 00:38:05,616 AT THEIR MECHANISM. 610 00:38:05,683 --> 00:38:08,352 WE LOOKED AT TWO HERE. 611 00:38:08,419 --> 00:38:18,896 SO CANNABIGEROL AT THE 2, 3 612 00:38:29,407 --> 00:38:33,611 POSITION IT CYCLIZES TO BECOME 613 00:38:33,678 --> 00:38:36,914 FROM STUDIES AND AS WELL AS FROM 614 00:38:36,981 --> 00:38:47,391 THE STUDIES AND THEN ALL THESE 615 00:38:47,458 --> 00:38:50,594 AND THEY'RE ALL SHOWING AN 616 00:38:50,661 --> 00:38:52,396 ANTIINFLAMMATORY EFFECT IN 617 00:38:52,463 --> 00:38:53,964 MICROGLIAL CELLS AND SIMILAR 618 00:38:54,031 --> 00:38:55,833 WITH OTHER MOLECULES WHICH HAS 619 00:38:55,900 --> 00:38:59,737 DOUBLE BOND IN SEVEN POSITIONS 620 00:38:59,804 --> 00:39:00,905 TARGETED WHICH ARE PHASE 1 DRUG 621 00:39:00,971 --> 00:39:10,681 METABOLISM. 622 00:39:10,748 --> 00:39:12,883 AND IT SHOWS EVERYWHERE IN THE 623 00:39:12,950 --> 00:39:16,287 BODY AND THE CANNABINOIDS CAN 624 00:39:16,353 --> 00:39:21,125 FORM THESE DIFFERENT PRODUCTS. 625 00:39:21,192 --> 00:39:23,627 DEPENDING ON THE SITE WE HAD 626 00:39:23,694 --> 00:39:25,229 DIFFERENT PRODUCTS AND THE 627 00:39:25,296 --> 00:39:31,736 PRIMARY PRODUCT WAS THE 6, 7 628 00:39:31,802 --> 00:39:33,437 EPO 629 00:39:33,504 --> 00:39:35,840 EPO 630 00:39:35,906 --> 00:39:39,543 EPO 631 00:39:39,610 --> 00:39:47,585 EPOXY CANNABICHROMINE AND WE 632 00:39:47,651 --> 00:39:51,322 STUDIED CBC AND CBG AND FOUND 633 00:39:51,388 --> 00:39:55,426 THE PRODUCT THAT WE PREDICTED 634 00:39:55,493 --> 00:39:57,561 WOULD BE FORMED WAS ACTUALLY 635 00:39:57,628 --> 00:40:00,131 FORMED IN THE MICE BLOOD AND WIN 636 00:40:00,197 --> 00:40:01,365 HALF AN HOUR OF THE 637 00:40:01,432 --> 00:40:03,467 DEMONSTRATION AND THEN 638 00:40:03,534 --> 00:40:03,768 DISAPPEARS. 639 00:40:03,834 --> 00:40:10,274 OUR HYPOTHESIS IS IT GETS 640 00:40:10,341 --> 00:40:16,247 TRANSFORMED BY THE ENZYMES AND 641 00:40:16,313 --> 00:40:19,750 THE IT REMAINS IN LARGER 642 00:40:19,817 --> 00:40:21,018 CONCENTRATION BUT FORM DIFFERENT 643 00:40:21,085 --> 00:40:30,294 PRODUCTS WE HAD PREDICTS. 644 00:40:30,361 --> 00:40:32,363 BOTH ARE STRONG METABOLIZING 645 00:40:32,429 --> 00:40:35,266 ENZYME AND THERE COULD BE A DRUG 646 00:40:35,332 --> 00:40:37,434 CANNABIS INFRACTION THE OUTCOME 647 00:40:37,501 --> 00:40:42,940 IS WE ELUCIDATED THE METABOLISM 648 00:40:43,007 --> 00:40:46,911 OF THE CANNABINOIDS BY THE 649 00:40:46,977 --> 00:40:52,550 FEDERAL P450s AND STEROID AND 650 00:40:52,616 --> 00:40:54,318 LIPID SYNTHESIS AND THESE 651 00:40:54,385 --> 00:40:56,954 METABOLITES ARE FORMED BUT BIO 652 00:40:57,021 --> 00:40:57,188 ACTIVE. 653 00:40:57,254 --> 00:41:01,559 FUTURE STUDIES WILL LOOK AT 654 00:41:01,625 --> 00:41:04,328 SELECTIVITY AND UNDERSTAND HOW 655 00:41:04,395 --> 00:41:09,633 THEY SELECT AND BECAUSE THE 656 00:41:09,700 --> 00:41:19,743 MOLECULES ARE TIED AND CAN THE 657 00:41:19,810 --> 00:41:24,782 COMPOUNDS BE USED FOR 658 00:41:24,849 --> 00:41:35,159 THERAPEUTICS AND. 659 00:41:38,929 --> 00:41:39,997 AND WE HAD PEOPLE IN THE 660 00:41:40,064 --> 00:41:41,966 CHEMISTRY FIELD AND THEY LOOKED 661 00:41:42,032 --> 00:41:42,867 HOW WE WERE LOOKING AT THE 662 00:41:42,933 --> 00:41:44,101 CANNABINOID MOLECULES. 663 00:41:44,168 --> 00:41:46,303 THIS IS OUR PROGRESS REPORT. 664 00:41:46,370 --> 00:41:48,239 WE HAVE FOUR PUBLICATIONS FROM 665 00:41:48,305 --> 00:41:58,716 THE WORK AND WORKING ON 666 00:41:59,783 --> 00:42:02,019 CANNABIGEROL AND THE MECHANISM 667 00:42:02,086 --> 00:42:06,724 OF CBD TO FORM CBE AND OTHER 668 00:42:06,790 --> 00:42:07,057 METABOLITES. 669 00:42:07,124 --> 00:42:08,225 THANK YOU MY LABORATORY AND 670 00:42:08,292 --> 00:42:09,059 THANK YOU EVERYBODY. 671 00:42:09,126 --> 00:42:11,729 I HOPE THAT WAS AT FIVE MINUTES. 672 00:42:11,795 --> 00:42:22,172 >> THANK YOU SO MUCH. 673 00:42:35,886 --> 00:42:46,363 >> WE'LL HAVE OUR NEXT SPEAKER. 674 00:42:47,398 --> 00:42:49,366 >> HI, EVERYONE. 675 00:42:49,433 --> 00:42:49,767 FWRAD TO BE HERE. 676 00:42:49,833 --> 00:42:53,971 TODAY I'LL BE TALKING ABOUT MY 677 00:42:54,038 --> 00:42:57,241 LAB AND CHRISTINA'S LAB LOOKING 678 00:42:57,308 --> 00:43:00,911 AT THE MINOR CANNABINOIDS AND 679 00:43:00,978 --> 00:43:04,381 TERPENES AND THE PRECLINICAL 680 00:43:04,448 --> 00:43:06,150 EVALUATION OF ANALGESICS AND 681 00:43:06,216 --> 00:43:07,751 TARGETS INVOLVED AND IMPLICATED 682 00:43:07,818 --> 00:43:09,553 IN PAIN AS WELL AS LOOK AT THEM 683 00:43:09,620 --> 00:43:11,755 IN MOUSE MODELS OF PAIN 684 00:43:11,822 --> 00:43:12,423 BEHAVIOR. 685 00:43:12,489 --> 00:43:18,362 WE'LL BE SEEING DATA FROM STEVE 686 00:43:18,429 --> 00:43:20,030 KINSEY'S LAB AND LOOK AT DATA 687 00:43:20,097 --> 00:43:22,032 FROM MY LABORATORY AS WELL. 688 00:43:22,099 --> 00:43:24,068 OUR HYPOTHESIS IS THE STUDIES 689 00:43:24,134 --> 00:43:24,868 OVER ALL IS MINOR CANNABINOIDS 690 00:43:24,935 --> 00:43:27,304 INTERACT WITH THE RECEPTORS AS 691 00:43:27,371 --> 00:43:28,505 INDICATED IN PAIN AND THIS HAS 692 00:43:28,572 --> 00:43:30,474 BEEN KNOWN AND SUGGESTED FOR 693 00:43:30,541 --> 00:43:31,508 QUITE SOME TIME NOW. 694 00:43:31,575 --> 00:43:33,444 AND THAT IN THE BEHAVIORAL 695 00:43:33,510 --> 00:43:34,712 MODELS WE'LL SEE EFFECTS OR 696 00:43:34,778 --> 00:43:42,920 ANALGESIC LIKE EFFECTS. 697 00:43:42,987 --> 00:43:47,024 SO STEVE KINSEY'S LAB DEVELOPED 698 00:43:47,091 --> 00:43:49,560 THIS ARTHRITIS MODEL USING IN 699 00:43:49,626 --> 00:43:49,793 MICE. 700 00:43:49,860 --> 00:43:50,928 AND WE CAN SEE THERE'S A COUPLE 701 00:43:50,995 --> 00:43:52,896 DIFFERENT WAYS IN WHICH THEY CAN 702 00:43:52,963 --> 00:43:55,099 QUANTIFY ARTHRITIC LIKE EFFECTS 703 00:43:55,165 --> 00:43:57,234 IN MICE. 704 00:43:57,301 --> 00:43:58,902 THE FIRST BEING ARTHRITIS 705 00:43:58,969 --> 00:44:02,873 SEVERITY AND THE SCORE OF 706 00:44:02,940 --> 00:44:06,543 PHYSICAL OR VISUAL SIGNS OF 707 00:44:06,610 --> 00:44:06,810 ARTHRITIS. 708 00:44:06,877 --> 00:44:09,413 HERE IN THE PAW THERE'S REDUCED 709 00:44:09,480 --> 00:44:10,581 COLLAGEN AND REDNESS AND 710 00:44:10,647 --> 00:44:14,852 INFLAMMATION OF THE DIGITS AND A 711 00:44:14,918 --> 00:44:16,620 SCORE CRITERIA AND CAN GET 712 00:44:16,687 --> 00:44:17,054 ARTHRITIS SEVERITY. 713 00:44:17,121 --> 00:44:20,791 YOU CAN SEE IN CONTROL ANIMALS 714 00:44:20,858 --> 00:44:21,959 THEY'RE NOT SHOWING ARTHRITIS 715 00:44:22,026 --> 00:44:24,294 OVER THE TIME COURSE OF THE 716 00:44:24,361 --> 00:44:26,630 STUDY HOWEVER, ANIMALS WITH 717 00:44:26,697 --> 00:44:31,735 COLLAGEN BY DAY NINE, 10, 11 THE 718 00:44:31,802 --> 00:44:35,172 EFFECTS GO UP AND WITH A STEROID 719 00:44:35,239 --> 00:44:37,107 THEY BLOCK OUT THE EFFECT. 720 00:44:37,174 --> 00:44:45,649 LOOKING AT THE COMPOUND DELTA H 721 00:44:45,716 --> 00:44:56,260 AND THE CABBINOL AND ALSO LOOKED 722 00:44:57,528 --> 00:45:00,431 AT THE BIO CHEMICAL ASSAYS AND 723 00:45:00,497 --> 00:45:06,937 CYTOKINE AND REDUCTIONS OCCURRED 724 00:45:07,004 --> 00:45:10,040 AS WELL AS WE SEE A RECOVERY OF 725 00:45:10,107 --> 00:45:10,674 DEPRESSION OBSERVED WITH THE 726 00:45:10,741 --> 00:45:13,243 COLLAGEN IN THE ANIMALS. 727 00:45:13,310 --> 00:45:14,878 IN TERMS OF BEHAVIORAL ASSAYS 728 00:45:14,945 --> 00:45:19,149 HAY -- THEY LOOKED AT GRIP 729 00:45:19,216 --> 00:45:21,618 STRENGTH AND THE AMOUNT OF TIME 730 00:45:21,685 --> 00:45:23,220 THE ANIMAL IS ABLE TO HOLD ON TO 731 00:45:23,287 --> 00:45:25,756 THE GRID AND YOU CAN SEE WITH 732 00:45:25,823 --> 00:45:27,091 THE EXPERIMENT WITH THE OTHER 733 00:45:27,157 --> 00:45:29,193 PHYSICAL MEASURES THEY'RE 734 00:45:29,259 --> 00:45:31,061 OBSERVING WE GET DECREASE IN 735 00:45:31,128 --> 00:45:32,596 LATENCY IN THE FALL SUGGESTING 736 00:45:32,663 --> 00:45:36,133 THE REDUCTION IN THE ABILITY TO 737 00:45:36,200 --> 00:45:36,967 GRIP THE GRID. 738 00:45:37,034 --> 00:45:40,504 THIS IS RECOVERED BY THE 739 00:45:40,571 --> 00:45:40,871 CABBINOL. 740 00:45:40,938 --> 00:45:43,640 IN ADDITIONALLY THERE'S THE 741 00:45:43,707 --> 00:45:46,643 CLIMBINGEST IT AND THIS IS A 742 00:45:46,710 --> 00:45:47,744 DIFFERENT ASSAY AND THE PAIN 743 00:45:47,811 --> 00:45:48,679 DEPRESSED BEHAVIOR. 744 00:45:48,745 --> 00:45:50,747 WHEN YOU ASSAY ANIMALS YOU GET 745 00:45:50,814 --> 00:46:01,258 THE INCREASE IN BEHAVIOR. 746 00:46:16,073 --> 00:46:25,282 AND WE SEE THE POSITIVE CONTROL. 747 00:46:25,349 --> 00:46:30,154 AND SOME RINGS HAVE HIGH OR LOW 748 00:46:30,220 --> 00:46:31,755 TEMPERATURE AND WE CAN LOOK AT 749 00:46:31,822 --> 00:46:33,257 THEIR THERMAL PREFERENCE AND 750 00:46:33,323 --> 00:46:35,726 WITH COLLAGEN INDUCED ARTHRITIS 751 00:46:35,792 --> 00:46:38,996 THEY GET THE INCREASE IN 752 00:46:39,062 --> 00:46:39,730 PREFERENCE IN TEMPERATURE 753 00:46:39,796 --> 00:46:42,065 BROUGHT BACK DOWN TO CONTROL 754 00:46:42,132 --> 00:46:45,035 LEVELS IN COLLAGEN AND IT'S THE 755 00:46:45,102 --> 00:46:47,604 FIRST TIME THIS HAS BEEN DONE TO 756 00:46:47,671 --> 00:46:51,041 SHOW THE ARTHRITIS MODEL. 757 00:46:51,108 --> 00:46:51,775 ADDITIONALLY WE LOOKED AT THE 758 00:46:51,842 --> 00:46:54,811 MOBILITY AND SHOWED THERE'S NOT 759 00:46:54,878 --> 00:46:56,747 A GREAT CHANGE IN MOBILITY TIME 760 00:46:56,813 --> 00:47:00,417 VERSUS THE CONTROL ANIMALS. 761 00:47:00,484 --> 00:47:03,220 AND LOOKING AT THE COMPOUNDS AND 762 00:47:03,287 --> 00:47:05,289 BINDING AND FUNCTION THE DELTA 763 00:47:05,355 --> 00:47:07,925 THC IS SIMILAR TO THE GREEN AND 764 00:47:07,991 --> 00:47:10,127 THE GREEN CURVES AS WELL AS 765 00:47:10,194 --> 00:47:12,863 FUNCTIONALLY IN THE FINDINGS AND 766 00:47:12,930 --> 00:47:15,732 SEE AGONIST ACTIVITY OF THE 767 00:47:15,799 --> 00:47:18,635 RECEPTORS. 768 00:47:18,702 --> 00:47:23,740 IT IS OBVIOUSLY A CANNABINOID 1 769 00:47:23,807 --> 00:47:33,617 AND 2 AGONIST. 770 00:47:33,684 --> 00:47:41,225 ALSO, STEVE KINSEY IS 771 00:47:41,291 --> 00:47:42,793 COLLABORATING WITH UCONN AND 772 00:47:42,859 --> 00:47:43,527 SHOWS THIS DATA. 773 00:47:43,594 --> 00:47:44,294 NEXT STEPS AND FUTURE 774 00:47:44,361 --> 00:47:45,362 OPPORTUNITIES FOR THE STUDIES 775 00:47:45,429 --> 00:47:47,731 WELL CONTINUE TO LOOK AT THE 776 00:47:47,798 --> 00:47:48,365 PHARMACOLOGY OF THE COMPOUNDS 777 00:47:48,432 --> 00:47:51,301 AND OTHER TARGETS AND IT'S BEEN 778 00:47:51,368 --> 00:47:51,535 ONGOING. 779 00:47:51,602 --> 00:47:52,769 I SHOULD MENTION MUCH OF THIS 780 00:47:52,836 --> 00:47:54,137 WORK WAS DONE AND THE BEHAVIORAL 781 00:47:54,204 --> 00:47:56,206 WORK IN ANIMALS WAS DONE AT 782 00:47:56,273 --> 00:47:57,574 UCONN, MOLECULAR WORK WAS DONE 783 00:47:57,641 --> 00:48:00,711 AT RTI WHERE I USED TO BE BUT 784 00:48:00,777 --> 00:48:03,747 NOW AT UPSTATE AND WE'LL BE 785 00:48:03,814 --> 00:48:05,716 LOOKING THE OTHER TARGETS AND 786 00:48:05,782 --> 00:48:07,017 THE PHARMACOLOGY OF THE 787 00:48:07,084 --> 00:48:07,784 COMPOUNDS AND ANOTHER ASSAY 788 00:48:07,851 --> 00:48:11,488 WE'LL GETTING UP AND RUNNING IS 789 00:48:11,555 --> 00:48:14,358 THE PAVLOVIAN DISCRIMINATION 790 00:48:14,424 --> 00:48:16,159 PARADIGM AND LOOK AT THE OBVIOUS 791 00:48:16,226 --> 00:48:18,662 RELATED POTENTIAL EFFECTS AND 792 00:48:18,729 --> 00:48:20,130 WE'VE BEEN LOOKING THE DRUG 793 00:48:20,197 --> 00:48:24,901 DISCRIMINATION BEHAVIOR IN 794 00:48:24,968 --> 00:48:25,135 ANIMALS. 795 00:48:25,202 --> 00:48:26,837 THERE'S A PROCEDURE TO LOOK AT 796 00:48:26,903 --> 00:48:30,507 WHETHER THE DRUG PRODUCE PSYCHO 797 00:48:30,574 --> 00:48:32,576 ACTIVE EFFECTS VERSUS JUST 798 00:48:32,643 --> 00:48:33,343 CANNABINOID EFFECTS AND STEVE 799 00:48:33,410 --> 00:48:36,346 KINSEY WILL LOOK AT THE EFFECTS 800 00:48:36,413 --> 00:48:38,081 IN THE MODEL BUT USING FEMALE 801 00:48:38,148 --> 00:48:42,486 MICE BECAUSE I DIDN'T MENTION 802 00:48:42,552 --> 00:48:45,122 ALL THE MICE WERE MALE MICE BUT 803 00:48:45,188 --> 00:48:46,890 IT'S VERY DIFFICULT IN THE 804 00:48:46,957 --> 00:48:48,058 LITERATURE AND THAT'S 805 00:48:48,125 --> 00:48:48,358 EVERYTHING. 806 00:48:48,425 --> 00:48:53,196 THANK YOU VERY MUCH FOR 807 00:48:53,263 --> 00:48:53,697 LISTENING. 808 00:48:53,764 --> 00:48:56,333 >> THANK YOU SO MUCH. 809 00:48:56,400 --> 00:49:06,810 YOU THANK YOU VERY MUCH. 810 00:49:10,781 --> 00:49:11,782 OUR NEXT SPEAKER IS PRESENTING 811 00:49:11,848 --> 00:49:15,018 ON OPTIMIZATION OF CBD MEDIATED 812 00:49:15,085 --> 00:49:16,820 ANALGESIC EFFECTS. 813 00:49:16,887 --> 00:49:19,556 >> I'M KUAN HONG WANG FROM THE 814 00:49:19,623 --> 00:49:22,592 UNIVERSITY OF RODCHESTER 815 00:49:22,659 --> 00:49:26,296 PRESENTING ON MECHANISM AND 816 00:49:26,363 --> 00:49:29,599 OPTIMIZATION OF CBD MEDIATED 817 00:49:29,666 --> 00:49:34,137 ANALGESIC EFFECTS ON BEHALF OF 818 00:49:34,204 --> 00:49:34,838 MY LABS. 819 00:49:34,905 --> 00:49:39,676 SO OVER ALL OBJECTIVES IS TO 820 00:49:39,743 --> 00:49:41,812 IDENTIFY THE IN VIVO ACTION OF 821 00:49:41,878 --> 00:49:45,449 CBD AND NEURO CIRCUIT MECHANISM 822 00:49:45,515 --> 00:49:46,683 FOR ANALGESIA. 823 00:49:46,750 --> 00:49:49,853 WE CAME TO THIS TOPIC BECAUSE 824 00:49:49,920 --> 00:49:54,524 OUR RECENT STUDIES WHERE WE 825 00:49:54,591 --> 00:49:57,394 COLLABORATED WITH DR. WOLF AT 826 00:49:57,461 --> 00:49:59,730 BOSTON CHILDREN'S HOSPITAL AND 827 00:49:59,796 --> 00:50:04,201 USED THE ANIMAL MODEL OF 828 00:50:04,267 --> 00:50:06,870 NEUROPATHIC PAIN TRIGGERED BY 829 00:50:06,937 --> 00:50:11,675 INJURY IN OUR STUDIES AND 830 00:50:11,742 --> 00:50:13,510 THROUGH A SERIES OF CIRCUIT 831 00:50:13,577 --> 00:50:16,947 TRACING AND NEURAL IMAGING AND 832 00:50:17,013 --> 00:50:18,982 MANIPULATION STUDIES WE 833 00:50:19,049 --> 00:50:22,219 IDENTIFIED CENTRAL SENSITIZATION 834 00:50:22,285 --> 00:50:26,656 ALONG THE NEURAL AXIS AND WE 835 00:50:26,723 --> 00:50:30,727 FOUND THAT THE MAJOR ROLE BY THE 836 00:50:30,794 --> 00:50:37,000 SOMATO SENSORY CORTICAL NEURONS 837 00:50:37,067 --> 00:50:41,538 WHICH COMPLETE SPINAL POSITIVE 838 00:50:41,605 --> 00:50:46,777 FEEDBACK LOOP AND REGULATE THE 839 00:50:46,843 --> 00:50:47,744 TACTILE SENSITIVITY AND 840 00:50:47,811 --> 00:50:52,749 SENSITIVITY TO CLASSIC PAIN WE 841 00:50:52,816 --> 00:50:54,718 THINK IN THE DIRECT SPINE 842 00:50:54,785 --> 00:50:56,920 CONNECTION MAY PROVIDE A 843 00:50:56,987 --> 00:51:03,126 SUBSTRATE FOR HOW OUR MENTAL 844 00:51:03,193 --> 00:51:05,562 STATE MODULATES PAIN AND GIVEN 845 00:51:05,629 --> 00:51:08,865 THE SENSITIVITY IN THE LOOP AND 846 00:51:08,932 --> 00:51:15,105 THINK IT'S LIKELY LIKELY TO BE 847 00:51:15,172 --> 00:51:15,605 MONT 848 00:51:15,672 --> 00:51:18,642 MODULATED BY THE CIRCUIT AND CBD 849 00:51:18,708 --> 00:51:21,111 COULD MODULATE THE INHIBITION 850 00:51:21,178 --> 00:51:26,783 THROUGH THE INTERACTION WITH THE 851 00:51:26,850 --> 00:51:29,619 INHIBITOR TRANSMITTERS AND 852 00:51:29,686 --> 00:51:31,455 THOUGH THE PREVIOUS STUDY MOSTLY 853 00:51:31,521 --> 00:51:36,993 DEPENDS ON THE BIO CHEMICAL AND 854 00:51:37,060 --> 00:51:39,729 IN VITRO APPROACH. 855 00:51:39,796 --> 00:51:45,435 WE HYPOTHESIZED A CBD WILL 856 00:51:45,502 --> 00:51:47,437 EXPRESS THE SPINAL CORTICAL LOOP 857 00:51:47,504 --> 00:51:51,341 TO PROVIDE RELIEF AND OUR 858 00:51:51,408 --> 00:51:55,312 APPROACH IS MAINLY IN VIVO OF 859 00:51:55,378 --> 00:51:56,780 BEHAVIOR AND EPIDEMIOLOGICAL 860 00:51:56,847 --> 00:51:59,249 STUDIES AND TO HIGHLIGHT A KEY 861 00:51:59,316 --> 00:52:03,720 SET OF INTERESTING FINDINGS, WE 862 00:52:03,787 --> 00:52:05,922 FOUND ROBOTS WITH INHIBITOR 863 00:52:05,989 --> 00:52:07,724 ACTION IN PAST PAIN BEHAVIORS 864 00:52:07,791 --> 00:52:10,560 AND SENSORY CIRCUITS. 865 00:52:10,627 --> 00:52:15,732 SO PARTICULARLY IN THE BEHAVIOR 866 00:52:15,799 --> 00:52:21,238 STUDIES WE PERFORMED A CURVE BY 867 00:52:21,304 --> 00:52:24,274 APPLYING A SERIES OF DIFFERENT 868 00:52:24,341 --> 00:52:27,244 PRESSURES TO THE MOUSE IN THE 869 00:52:27,310 --> 00:52:31,314 PERIPHERAL MODEL. 870 00:52:31,381 --> 00:52:41,925 YOU CAN SEE AND YOU CAN SEE THE 871 00:52:53,403 --> 00:52:58,074 ALLODYNIA AND HYPERALGESIA AND 872 00:52:58,141 --> 00:53:01,411 WHEN WE CONDUCT THE CURVE WE 873 00:53:01,478 --> 00:53:11,454 DIDN'T SEE ALTERATION IN THE 874 00:53:11,521 --> 00:53:13,623 ININNOCUOUS AND INNOCUOUS RANGE 875 00:53:13,690 --> 00:53:17,661 AND WE GET THE REDUCTION OF 876 00:53:17,727 --> 00:53:19,729 ACUTE PAIN. 877 00:53:19,796 --> 00:53:25,001 THE CBD EFFECT IS SELECTED FOR 878 00:53:25,068 --> 00:53:26,336 IMPORTANT THERAPEUTIC 879 00:53:26,403 --> 00:53:26,636 APPLICATION. 880 00:53:26,703 --> 00:53:37,180 THE AND THIS DOESN'T AFFECT THE 881 00:53:37,247 --> 00:53:39,583 ACUTE PAIN AND AT THE NEURAL 882 00:53:39,649 --> 00:53:42,085 LEVEL WE STUDY THE CORTICAL 883 00:53:42,152 --> 00:53:46,723 SENSORY TAR GETS LOOKING AT THE 884 00:53:46,790 --> 00:53:49,025 RELABELLING AND LOOKING AT THE 885 00:53:49,092 --> 00:53:53,997 IN VIVO IMAGING WITH THE CAMERA 886 00:53:54,064 --> 00:53:55,131 AND MONITOR THE NEURONAL 887 00:53:55,198 --> 00:53:56,967 ACTIVITY AND LOOKED AMOUNT THE 888 00:53:57,033 --> 00:54:00,737 BEHAVIORS AND ACTIVITY. 889 00:54:00,804 --> 00:54:02,672 BASICALLY IN THE NEUROPATHIC 890 00:54:02,739 --> 00:54:04,708 PAIN MODEL WE GET HYPERACTIVITY 891 00:54:04,774 --> 00:54:06,343 OF THE SENSORY SPINAL NEURONS 892 00:54:06,409 --> 00:54:09,679 AND THAT IS GREATLY REDUCED BY 893 00:54:09,746 --> 00:54:13,016 CBD AND IN THE INTACT ANIMALS 894 00:54:13,083 --> 00:54:16,553 THE NEURONS WILL ONLY RESPOND 895 00:54:16,620 --> 00:54:18,221 MODESTLY TO THE LOW PRESSURE AND 896 00:54:18,288 --> 00:54:21,491 THIS RESPONSE WAS NOT ALTERED BY 897 00:54:21,558 --> 00:54:21,658 CBD. 898 00:54:21,725 --> 00:54:23,126 BOTH AT THE NEURAL AND 899 00:54:23,193 --> 00:54:29,466 BEHAVIORAL LEVEL WE GET A ROBUST 900 00:54:29,532 --> 00:54:32,068 SUPPRESSION OF PAIN AND SPARED 901 00:54:32,135 --> 00:54:39,409 THE SOMATOSENSORY RESPONSE. 902 00:54:39,476 --> 00:54:43,013 MOVING FORWARD WE THINK THERE'S 903 00:54:43,079 --> 00:54:49,519 THERE'S AN IMPORTANT APPROACH TO 904 00:54:49,586 --> 00:54:51,187 INTEGRATE THE SPECIFICITY OF 905 00:54:51,254 --> 00:54:53,523 CANNABINOIDS AT MULTIPLE LEVELS 906 00:54:53,590 --> 00:54:55,025 TO BETTER OPTIMIZE THE 907 00:54:55,091 --> 00:54:56,760 THERAPEUTIC TRANSLATION. 908 00:54:56,826 --> 00:54:58,495 I DON'T HAVE TIME TO TALK ABOUT 909 00:54:58,561 --> 00:54:59,429 SOME EFFORTS ALREADY DONE SO 910 00:54:59,496 --> 00:55:05,935 WE'VE BEEN LOOKING AT THE BIO 911 00:55:06,002 --> 00:55:09,706 AVAILABILITY OF THE CBD THROUGH 912 00:55:09,773 --> 00:55:13,009 ALTERATIONS AND PERFORMED A 913 00:55:13,076 --> 00:55:14,210 STUDY TO BETTER UNDERSTAND HOW 914 00:55:14,277 --> 00:55:17,714 TO THE COMPOUND CAN ACHIEVE A 915 00:55:17,781 --> 00:55:21,484 STATE DEPENDENT EFFECT LIKE 916 00:55:21,551 --> 00:55:23,953 EXCITABILITY AND CONDUCTED 917 00:55:24,020 --> 00:55:26,222 SPINAL BRAIN-WIDE MAPPING OF THE 918 00:55:26,289 --> 00:55:27,657 DIFFERENT POPULATION OF NEURONS 919 00:55:27,724 --> 00:55:34,130 THAT COULD BE EFFECTED BY CBD. 920 00:55:34,197 --> 00:55:35,732 SO CBD'S ACTION THOUGH I 921 00:55:35,799 --> 00:55:39,736 HIGHLIGHT THE SENSORY NEURONS 922 00:55:39,803 --> 00:55:42,272 IT'S BECAUSE WE HAVE AFFECTED 923 00:55:42,338 --> 00:55:47,577 MULTIPLE TARGETS ALONG THE 924 00:55:47,644 --> 00:55:51,748 CENTRAL NEURAL PATHWAY AND THAT 925 00:55:51,815 --> 00:55:53,149 LEADS TO THE PAIN RELIEVING 926 00:55:53,216 --> 00:55:55,051 BEHAVIOR. 927 00:55:55,118 --> 00:55:58,021 I THINK THIS WILL BE AN 928 00:55:58,088 --> 00:55:58,621 INTERESTING QUESTION WE'LL 929 00:55:58,688 --> 00:55:59,589 CONTINUE TO ADDRESS. 930 00:55:59,656 --> 00:56:02,625 WITH THAT I'LL ACKNOWLEDGE THE 931 00:56:02,692 --> 00:56:04,627 KEY PEOPLE INVOLVED IN THE STUDY 932 00:56:04,694 --> 00:56:05,028 IN BOTH LOCATIONS. 933 00:56:05,095 --> 00:56:12,669 THANK YOU VERY MUCH. 934 00:56:12,736 --> 00:56:14,471 >> THANK YOU. 935 00:56:14,537 --> 00:56:17,774 WE HAVE ONE FINAL SPEAKER, 936 00:56:17,841 --> 00:56:22,412 DR. MYRA RICE. 937 00:56:22,479 --> 00:56:30,487 DR. RICE CANDIDATES WILL PRESENT 938 00:56:30,553 --> 00:56:32,756 ON MOTIVATION OF 939 00:56:32,822 --> 00:56:34,257 HYPERSENSITIVITY BY PREFERENCE 940 00:56:34,324 --> 00:56:36,693 THE CANNABINOID RELEASE IN THE 941 00:56:36,760 --> 00:56:38,528 CENTRAL CIRCUITS AND WE'LL HAVE 942 00:56:38,595 --> 00:56:42,699 TIME MAYBE FOR TWO QUESTIONS SO 943 00:56:42,766 --> 00:56:45,568 THIS WILL BE A RACE TO THE 944 00:56:45,635 --> 00:56:45,869 MICROPHONE. 945 00:56:45,935 --> 00:56:47,771 THE FIRST TWO PEOPLE WILL BE 946 00:56:47,837 --> 00:56:49,038 ABLE TO ASK QUESTIONS. 947 00:56:49,105 --> 00:56:55,011 THANK YOU. 948 00:56:55,078 --> 00:56:59,749 >> I'M MYRA RICE LOOKING AT THE 949 00:56:59,816 --> 00:57:01,785 ROOM MECHANISMS FOR NOCICEPTION 950 00:57:01,851 --> 00:57:11,327 AND MOUSE MODELS OF PAIN. 951 00:57:11,394 --> 00:57:14,898 SO OUTCOME MEASURES I'LL BE 952 00:57:14,964 --> 00:57:19,035 TALKING ABOUT ARE THRESHOLDS IN 953 00:57:19,102 --> 00:57:20,970 MICE OF COURSE AND CBD 1 954 00:57:21,037 --> 00:57:23,740 RECEPTOR IN CELL CULTURE 955 00:57:23,807 --> 00:57:34,017 EXPERIMENTS. 956 00:57:35,385 --> 00:57:39,088 AND MYRCENE HAS BEEN IN 957 00:57:39,155 --> 00:57:39,722 INFLAMMATORY MODELS AND WE 958 00:57:39,789 --> 00:57:42,525 REPLICATE THE FINDINGS IN A 959 00:57:42,592 --> 00:57:44,093 CHRONIC CONSTRUCTION INJURY 960 00:57:44,160 --> 00:57:46,830 NERVE MODEL OF NEUROPATHIC PAIN 961 00:57:46,896 --> 00:57:49,032 AND UNCOVERING MECHANISMS 962 00:57:49,098 --> 00:57:54,103 NOCICEPTION. 963 00:57:54,170 --> 00:57:55,805 SO, I'LL BE DISCUSSING IN VIVO 964 00:57:55,872 --> 00:57:59,008 FINDINGS ON THE TOP ROW AND I 965 00:57:59,075 --> 00:58:01,044 USE A CHRONIC CONSTRICTION 966 00:58:01,110 --> 00:58:06,216 INJURY MODEL WHERE THE MOUSE'S 967 00:58:06,282 --> 00:58:08,451 SCIATIC NERVE HAS TUBING AND 968 00:58:08,518 --> 00:58:10,320 I'LL BE DESCRIBING THE 969 00:58:10,386 --> 00:58:11,721 THRESHOLDS ON THE Y AXIS AND 970 00:58:11,788 --> 00:58:13,990 THIS DESCRIBES THE AMOUNT OF 971 00:58:14,057 --> 00:58:15,458 FORCE THE ANIMAL CAN WITH STAND 972 00:58:15,525 --> 00:58:17,293 ON THE INJURED PAW. 973 00:58:17,360 --> 00:58:20,830 SO FIGURE ONE IS SHOWING A DOSE 974 00:58:20,897 --> 00:58:22,765 RESPONSE CURVE FOR MYRCENE AT 975 00:58:22,832 --> 00:58:25,068 VARIOUS DOSES AND WITH HIGHER 976 00:58:25,134 --> 00:58:31,040 DOSES OF GLYCINE THE ANIMAL CAN 977 00:58:31,107 --> 00:58:36,679 WITH STAND MORE MORSE -- FORCE 978 00:58:36,746 --> 00:58:38,081 AND THE ANTAGONIST PRETREATMENT 979 00:58:38,147 --> 00:58:42,352 OF MYRCENE IS ABLE TO BLOCK 980 00:58:42,418 --> 00:58:46,122 THESE ANTI-ANALGESIC EFFECTS AND 981 00:58:46,189 --> 00:58:49,459 THIS IS DISPLAYED AND THESE ARE 982 00:58:49,525 --> 00:58:52,362 GOING TO BE THE VEHICLE 983 00:58:52,428 --> 00:58:54,964 PRE-TREATED MYRCENE COMPARISON 984 00:58:55,031 --> 00:58:59,736 TO THE UPSIDE-DOWN PRE-TREATED 985 00:58:59,802 --> 00:59:00,370 MYRCENE. 986 00:59:00,436 --> 00:59:02,572 AND ADDITIONALLY IF YOU NOTICE 987 00:59:02,639 --> 00:59:05,508 THAT THE CB1 ANTAGONIST 988 00:59:05,575 --> 00:59:07,543 PRE-TREATMENT GROUP IS NOT 989 00:59:07,610 --> 00:59:08,111 STATISTICALLY SIGNIFICANT 990 00:59:08,177 --> 00:59:08,978 COMPARED TO THE VEHICLE CONTROL 991 00:59:09,045 --> 00:59:11,948 GROUP. 992 00:59:12,015 --> 00:59:14,183 NOW I'M GOING TO BE DESCRIBING 993 00:59:14,250 --> 00:59:17,620 SOME IN VITRO STUDIES THAT WERE 994 00:59:17,687 --> 00:59:20,056 DONE USING CELL CULTURE ASSAYS 995 00:59:20,123 --> 00:59:22,458 USING AT THE PROTEIN ACTIVATION 996 00:59:22,525 --> 00:59:23,726 IN THE ASSAY. 997 00:59:23,793 --> 00:59:29,265 SO I'LL BE DESCRIBING CHANGE IN 998 00:59:29,332 --> 00:59:31,067 THE BIO LUMINESCENCE ENERGY 999 00:59:31,134 --> 00:59:33,770 TRANSFER AND THIS HAPPENS WHEN 1000 00:59:33,836 --> 00:59:35,238 THERE'S A DISASSOCIATION OF THE 1001 00:59:35,305 --> 00:59:36,239 SUB UNIT WHEN THE RECEPTOR IS 1002 00:59:36,306 --> 00:59:38,474 ACTIVATED. 1003 00:59:38,541 --> 00:59:42,912 SO FIGURE 4 IS SHOWING MYRCENE 1004 00:59:42,979 --> 00:59:46,649 COMPARED TO AN A CB1 AGONIST AND 1005 00:59:46,716 --> 00:59:48,618 MYRCENE IS NOT BEHAVING LIKE THE 1006 00:59:48,685 --> 00:59:49,652 AGONIST AT ALL. 1007 00:59:49,719 --> 00:59:55,325 AND THEN FIGURES 5 AND 6 ARE 1008 00:59:55,391 --> 00:59:58,828 SHOWING TWO ENDOGENOUS 1009 00:59:58,895 --> 01:00:00,697 CANNABINOIDS WITH AND WITHOUT 1010 01:00:00,763 --> 01:00:04,567 THE ADDITION OF 10 MICROMOLARS 1011 01:00:04,634 --> 01:00:07,003 OF MYRCENE SO IT'S NOT 1012 01:00:07,070 --> 01:00:07,804 MODULATING THE CANNABINOID ON 1013 01:00:07,870 --> 01:00:13,576 THE CB1 RECEPTORS. 1014 01:00:13,643 --> 01:00:17,080 THE NEXT STEPS ARE TO 1015 01:00:17,146 --> 01:00:20,016 INVESTIGATE HOW MYRCENE HAS 1016 01:00:20,083 --> 01:00:22,385 THESE ANALGESIC PROPERTIES IN 1017 01:00:22,452 --> 01:00:26,222 VIVO BLOCKED BY THE CB1 AGONIST 1018 01:00:26,289 --> 01:00:27,757 AND YET IN VITRO IT'S NOT 1019 01:00:27,824 --> 01:00:29,659 BINDING OR MODULATING 1020 01:00:29,726 --> 01:00:30,960 CANNABINOID ACTIVITY. 1021 01:00:31,027 --> 01:00:31,894 SO FUTURE STEPS FOR FIELD AND 1022 01:00:31,961 --> 01:00:38,968 FOR MY LAB ARE GOING TO BE TO 1023 01:00:39,035 --> 01:00:43,306 USE FIBER PHYTO METRY AND LOOK 1024 01:00:43,373 --> 01:00:48,411 AT THE SENSOR AND THIS IS A 1025 01:00:48,478 --> 01:00:51,914 MODIFIED CB1 RECEPTOR SO WHEN 1026 01:00:51,981 --> 01:00:54,350 IT'S BOUND THERE'S A CHANGE AND 1027 01:00:54,417 --> 01:00:59,288 THIS CAN BE MEASURED AND I'M 1028 01:00:59,355 --> 01:01:06,796 PARTICULARLY INTERESTED IN THE 1029 01:01:06,863 --> 01:01:12,735 VENTROLATERAL PERIAQUEDUCTAL 1030 01:01:12,802 --> 01:01:16,139 GRAY AND SEX DIFFERENCES HAVE 1031 01:01:16,205 --> 01:01:19,075 BEEN FOUND IN CIRCUITS INVOLVED 1032 01:01:19,142 --> 01:01:21,377 I'M FROM IN THE LATERAL 1033 01:01:21,444 --> 01:01:23,946 HYPERTHALAMUS TO THE PERILATERAL 1034 01:01:24,013 --> 01:01:34,524 PER I AQUA -- PERIAQUADUCTAL 1035 01:01:38,928 --> 01:01:38,995 GRAY. 1036 01:01:39,062 --> 01:01:42,131 >> THREW FOR STAYING ON TIME. 1037 01:01:42,198 --> 01:01:44,067 WE HAVE A COUPLE MINUTES FOR 1038 01:01:44,133 --> 01:01:45,635 BURNING QUESTIONS. 1039 01:01:45,701 --> 01:01:50,673 AND WE HAVE ONE. 1040 01:01:50,740 --> 01:02:00,850 GREAT. 1041 01:02:15,865 --> 01:02:19,735 I HAVE A QUESTION FOR DING. 1042 01:02:19,802 --> 01:02:21,904 YOU MENTIONED ABOUT BINDING OF 1043 01:02:21,971 --> 01:02:23,906 YOUR PET TRACER IN THE BRAIN BUT 1044 01:02:23,973 --> 01:02:25,508 DID YOU ALSO SHOW SOME PICTURES 1045 01:02:25,575 --> 01:02:29,479 OF THE KNEE? 1046 01:02:29,545 --> 01:02:31,047 >> SORRY, DID I SHOW PICTURE OF 1047 01:02:31,114 --> 01:02:33,916 WHAT? 1048 01:02:33,983 --> 01:02:35,718 >> SOME OF THE PICTURES LOOKED 1049 01:02:35,785 --> 01:02:48,397 LIKE THEY WERE NOT TH>LIKE THEY. 1050 01:02:51,200 --> 01:02:57,540 >> DID YOU ALSO DO PET IMAGING 1051 01:02:57,607 --> 01:02:57,740 KNEE? 1052 01:02:57,807 --> 01:02:58,608 >> YES. 1053 01:02:58,674 --> 01:03:01,077 THIS SCANNER IS A WHOLE BODY 1054 01:03:01,144 --> 01:03:04,847 SCANNER. 1055 01:03:04,914 --> 01:03:07,550 SO WE LOOK AT BOTH BRAIN AND 1056 01:03:07,617 --> 01:03:08,050 KNEE. 1057 01:03:08,117 --> 01:03:10,753 YOU SEE THE KINETICS I SHOWED 1058 01:03:10,820 --> 01:03:13,456 WITH THE RIGHT KNEE IS THE 1059 01:03:13,523 --> 01:03:17,727 INJECTION SITE OF THE MIA TO 1060 01:03:17,793 --> 01:03:23,399 INDUCE THE OA AND FOR THE LEFT 1061 01:03:23,466 --> 01:03:29,972 KNEE AND THERE'S A VERY MINOR 1062 01:03:30,039 --> 01:03:31,307 INFLAMMATION. 1063 01:03:31,374 --> 01:03:35,711 >> YOU SAW THE CBD BINDS TO BOTH 1064 01:03:35,778 --> 01:03:37,246 THE RECEPTORS IN THE KNEE AND 1065 01:03:37,313 --> 01:03:42,585 THE BRAIN? 1066 01:03:42,652 --> 01:03:49,091 >> THIS IS AN INFLAMMATION 1067 01:03:49,158 --> 01:03:53,029 TARGET. 1068 01:03:53,095 --> 01:03:54,030 >> THE TOP PANEL IS TALKING 1069 01:03:54,096 --> 01:04:00,403 ABOUT THE RECEPTOR AND I SHOWED 1070 01:04:00,469 --> 01:04:06,609 BUT THE BOTTOM PANEL IS FOR THE 1071 01:04:06,676 --> 01:04:09,478 STUDY FOR TSPO. 1072 01:04:09,545 --> 01:04:14,917 FOR THAT STUDY I HAVE THE BRAIN 1073 01:04:14,984 --> 01:04:17,954 IMAGING SHOWING THAT AFTER THE 1074 01:04:18,020 --> 01:04:21,724 INDUCTION OF OA YOU SEE THE 1075 01:04:21,791 --> 01:04:23,659 UPREGULATION AND HIGHER UPTAKE 1076 01:04:23,726 --> 01:04:27,730 OF THE TRACER PBR28 AND ALSO IN 1077 01:04:27,797 --> 01:04:32,068 THE PERIPHERY IN TERMS OF KNEE. 1078 01:04:32,134 --> 01:04:35,438 RIGHT KNEE IS MUCH HIGHER 1079 01:04:35,504 --> 01:04:37,373 INFLAMMATION COMPARED TO LEFT 1080 01:04:37,440 --> 01:04:41,210 KNEE AND IF YOU USE AND USE THE 1081 01:04:41,277 --> 01:04:44,413 RATIO FOR THE FOUR STAGE YOU CAN 1082 01:04:44,480 --> 01:04:47,683 SEE THE BASELINE HAS NO TO 1083 01:04:47,750 --> 01:04:49,218 LITTLE INFLAMMATION BUT DAY SIX 1084 01:04:49,285 --> 01:04:54,957 HIGHER THAN DAY 13 AND THE 1085 01:04:55,024 --> 01:04:57,994 RESULT WITH REDUCTION OF 1086 01:04:58,060 --> 01:04:59,729 INFORMATION WITH CBD. 1087 01:04:59,795 --> 01:05:00,296 >> IN THE KNEE. 1088 01:05:00,363 --> 01:05:00,496 OKAY. 1089 01:05:00,563 --> 01:05:00,763 THANK YOU. 1090 01:05:00,830 --> 01:05:05,835 >> THANK YOU. 1091 01:05:05,901 --> 01:05:06,535 >> THANK YOU. 1092 01:05:06,602 --> 01:05:07,870 >> THANK YOU FOR THE QUESTION 1093 01:05:07,937 --> 01:05:10,940 AND ANSWER AND NOW MOVING TO THE 1094 01:05:11,007 --> 01:05:11,707 SECOND SESSION. 1095 01:05:11,774 --> 01:05:16,445 AGAIN IN THE NON-CLINICAL 1096 01:05:16,512 --> 01:05:17,046 STUDIES. 1097 01:05:17,113 --> 01:05:19,548 AGAIN, BRIEF FIVE-MINUTE 1098 01:05:19,615 --> 01:05:21,083 PRESENTATIONS AND NOW DR. RAWLS 1099 01:05:21,150 --> 01:05:21,984 IS THE FIRST SPEAKER OF THE 1100 01:05:22,051 --> 01:05:23,919 SECOND PORTION. 1101 01:05:23,986 --> 01:05:29,392 NOW, ON BEHALF OF CO-P.I. 1102 01:05:29,458 --> 01:05:32,228 DR. RAWLS FROM TEMPLE UNIVERSITY 1103 01:05:32,295 --> 01:05:35,731 LOOKING AT ROOM MECHANISMS AND 1104 01:05:35,798 --> 01:05:36,899 INTERACTIVE EFFECTS IN 1105 01:05:36,966 --> 01:05:37,700 NEUROPATHIC PAIN. 1106 01:05:37,767 --> 01:05:40,569 >> WONDERFUL, THANK YOU. 1107 01:05:40,636 --> 01:05:43,873 SO THIS IS AN R21 AWARDED TO 1108 01:05:43,939 --> 01:05:47,343 DR. RAWLS AND I IN AUGUST. 1109 01:05:47,410 --> 01:05:53,149 THIS WAS INSPIRED PARTLY BY A 1110 01:05:53,215 --> 01:05:57,720 STORE CALLED CBD KRATOM BY MY 1111 01:05:57,787 --> 01:06:01,090 CHILDREN'S MIDDLE AND HIGH 1112 01:06:01,157 --> 01:06:05,094 SCHOOLS AND THOUGHT I THOUGHT 1113 01:06:05,161 --> 01:06:09,999 WRITE A GRANT AND CBD AND KRATOM 1114 01:06:10,066 --> 01:06:12,735 ARE SOLD AND THE LARGEST 1115 01:06:12,802 --> 01:06:14,570 PREDICTOR OF WHETHER OR NOT 1116 01:06:14,637 --> 01:06:18,741 PEOPLE USE KRATO M IS WHETHER 1117 01:06:18,808 --> 01:06:21,844 PEOPLE USE ANTIBODY AND FOLKS A 1118 01:06:21,911 --> 01:06:23,979 LIKELIHOOD PEOPLE ARE CO-USING 1119 01:06:24,046 --> 01:06:30,052 THE PLANT DERIVED PRODUCTS AND 1120 01:06:30,119 --> 01:06:32,621 UNCLEAR WHETHER THERE ARE 1121 01:06:32,688 --> 01:06:33,989 EFFICACY REASONS FOR CO-USE AND 1122 01:06:34,056 --> 01:06:35,358 WHETHER THERE ARE REASONS TO BE 1123 01:06:35,424 --> 01:06:43,632 CONCERNED ABOUT THIS. 1124 01:06:43,699 --> 01:06:47,570 IT'S TO LOOK AT WHETHER THEY 1125 01:06:47,636 --> 01:06:49,305 CO-USE CAN CREATE ADVERSE 1126 01:06:49,372 --> 01:06:49,772 EFFECTS. 1127 01:06:49,839 --> 01:06:52,541 SO KRATOM IS A PLANT THAT FOLKS 1128 01:06:52,608 --> 01:06:55,177 USE FOR VARIOUS REASONS TO TREAT 1129 01:06:55,244 --> 01:06:59,715 ANXIETY, TO ALLEVIATE OPIOID 1130 01:06:59,782 --> 01:07:00,850 WITHDRAWAL SIGNS AS WELL AS TO 1131 01:07:00,916 --> 01:07:02,885 TREAT PAIN THAT IS NOT 1132 01:07:02,952 --> 01:07:05,421 RESPONSIVE TO CONVENTIONAL 1133 01:07:05,488 --> 01:07:05,721 ANALGESICS. 1134 01:07:05,788 --> 01:07:07,356 AGAIN, A LOT OF OVERLAP WITH THE 1135 01:07:07,423 --> 01:07:11,727 REASONS WHY SOME FOLKS ENDORSE 1136 01:07:11,794 --> 01:07:16,432 USING MEDICAL CANNABIS. 1137 01:07:16,499 --> 01:07:18,534 UNLIKE CANNABIS THERE'S 1138 01:07:18,601 --> 01:07:20,269 DIFFERENT COMPOUNDS IN KRATOM 1139 01:07:20,336 --> 01:07:21,704 ONE OF THE BIO ACTIVE SUBSTANCES 1140 01:07:21,771 --> 01:07:23,739 THAT HAS RECEIVE THE MOST 1141 01:07:23,806 --> 01:07:27,743 ATTENTION FROM THE RESEARCH 1142 01:07:27,810 --> 01:07:35,017 COMMUNITY IS A COMPOUND THAT WE 1143 01:07:35,084 --> 01:07:36,118 STARTED OUR RESEARCH ON. 1144 01:07:36,185 --> 01:07:38,587 IT HAS ACTIVITY AT OPIOID 1145 01:07:38,654 --> 01:07:40,022 RECEPTORS AND MAY BE RESPONSIBLE 1146 01:07:40,089 --> 01:07:43,726 FOR SOME OF THE REASONS WHY 1147 01:07:43,793 --> 01:07:47,730 FOLKS USE THIS IN DIFFERENT 1148 01:07:47,797 --> 01:07:50,699 THERAPEUTIC SETTINGS. 1149 01:07:50,766 --> 01:07:56,505 AS WELL AS THERE ARE ROOM 1150 01:07:56,572 --> 01:08:07,049 ACTIVITIES OF AND FOUND THE 1151 01:08:15,724 --> 01:08:26,035 BEHAVIORAL EFFECTS OF 1152 01:08:39,181 --> 01:08:40,416 CANNABINOIDS AND MYTRAGYNINE MAY 1153 01:08:40,483 --> 01:08:40,916 COME TO LIGHT. 1154 01:08:40,983 --> 01:08:43,285 WE'VE DONE WORK IN THIS AREA AND 1155 01:08:43,352 --> 01:08:47,423 WE'RE LOOKING AT CBD, CBG AND 1156 01:08:47,490 --> 01:08:53,229 DELTA 9THC IN COMBINATION WITH 1157 01:08:53,295 --> 01:08:54,330 MYTRAGYNINE IN MALE AND FEMALE 1158 01:08:54,396 --> 01:08:59,668 MICE AND THE PRIMARY MODELS ARE 1159 01:08:59,735 --> 01:09:05,574 THE CANNABINOID LOOKING AT 1160 01:09:05,641 --> 01:09:08,477 ANTINO RECEPTION AND THE MODEL 1161 01:09:08,544 --> 01:09:15,317 OF PAIN AND THE MODEL OF 1162 01:09:15,384 --> 01:09:15,951 NEUROPATHIC PAIN. 1163 01:09:16,018 --> 01:09:26,562 AND AB -- AND SOME HIGHLIGHT WE 1164 01:09:34,336 --> 01:09:44,280 FOUND OF THE POINT 1 IS THAT 1165 01:09:44,346 --> 01:09:46,482 MITRAGYNINE IS SHOWING EFFECTS 1166 01:09:46,549 --> 01:09:48,417 AND IF WE PRETREAT MICE BEFORE 1167 01:09:48,484 --> 01:09:51,720 THEY GET THEIR CHEMO AGENT WITH 1168 01:09:51,787 --> 01:09:55,758 MITRAGYNINE PREVENTS THE 1169 01:09:55,824 --> 01:09:58,460 DEVELOPMENT OF CHEMOTHERAPY 1170 01:09:58,527 --> 01:09:59,995 INDUCED SENSITIVITY AND HER WORK 1171 01:10:00,062 --> 01:10:02,131 WILL BE TO LOOK AT WHETHER AND 1172 01:10:02,197 --> 01:10:08,203 HOW THIS INTERACTS WITH THE 1173 01:10:08,270 --> 01:10:09,872 REVERSAL EFFECTS OF THE 1174 01:10:09,939 --> 01:10:14,209 CANNABINOIDS AND MIA IS WORKING 1175 01:10:14,276 --> 01:10:18,581 ON THE ASSAY AND SEE CBG AND 1176 01:10:18,647 --> 01:10:22,551 MITRAGYNINE ATTENUATE PHASE 2 1177 01:10:22,618 --> 01:10:23,786 BEHAVIORS AND AN INTERESTING 1178 01:10:23,852 --> 01:10:27,156 EFFECT WE SEE WITH CBG AND MAY 1179 01:10:27,222 --> 01:10:28,490 HAVE TO DO WITH THE SEDATIVE 1180 01:10:28,557 --> 01:10:31,193 EFFECTS BECAUSE WE ONLY SEE THE 1181 01:10:31,260 --> 01:10:34,330 EFFECT AT A HIGH DOSE AND AGAIN 1182 01:10:34,396 --> 01:10:37,266 MITRAGYNINE IS EFFECTIVE AT 1183 01:10:37,333 --> 01:10:39,735 REDUCING PHASE 2 BEHAVIORS 1184 01:10:39,802 --> 01:10:41,937 INDICATIVE OF AN 1185 01:10:42,004 --> 01:10:42,805 ANTIINFLAMMATORY EFFECT. 1186 01:10:42,871 --> 01:10:46,208 IN THE MANY ASSAY WE'RE SEEING 1187 01:10:46,275 --> 01:10:56,752 EFFECTS OF DELTA 9 THC AND 1188 01:11:01,290 --> 01:11:03,425 LOOKING AT THE PHYTO 1189 01:11:03,492 --> 01:11:05,461 CANNABINOIDS AND DON'T SEE 1190 01:11:05,527 --> 01:11:07,363 EFFECTS OF MITRAGYNINE IN THE 1191 01:11:07,429 --> 01:11:08,631 HOT PLATE SHOWING IT'S NOT 1192 01:11:08,697 --> 01:11:12,635 ACTING AS A VERY ROBUST OPIOID 1193 01:11:12,701 --> 01:11:14,036 AGONIST IN THE ASSAY. 1194 01:11:14,103 --> 01:11:16,338 HOWEVER, IT DOES REDUCE THE AN 1195 01:11:16,405 --> 01:11:19,375 TINNO RECEPTIVE EFFECT OF THC 1196 01:11:19,441 --> 01:11:22,678 AND CBG. 1197 01:11:22,745 --> 01:11:24,413 MITRAGYNINE IS REPORTED ON 1198 01:11:24,480 --> 01:11:26,148 HAVING STIMULANT LIKE PROPERTY 1199 01:11:26,215 --> 01:11:27,716 AND INTERESTED WHETHER THE 1200 01:11:27,783 --> 01:11:29,318 REDUCTION OF THIS BEHAVIOR ON 1201 01:11:29,385 --> 01:11:32,688 THE HOT PLATE HAS SOMETHING TO 1202 01:11:32,755 --> 01:11:37,159 DO INTERACTING WITH EFFECTS 1203 01:11:37,226 --> 01:11:43,632 OPPOSED TO ANTINOCICEPTIVE 1204 01:11:43,699 --> 01:11:45,234 EFFECTS AND THANK YOU FOR THE 1205 01:11:45,300 --> 01:11:48,003 FIVE MINUTES OF TIME WITH YOU 1206 01:11:48,070 --> 01:11:49,672 ALL. 1207 01:11:49,738 --> 01:11:51,306 >> THANK YOU. 1208 01:11:51,373 --> 01:11:54,510 THE NEXT SPEAKER IS 1209 01:11:54,576 --> 01:11:56,478 DR. STREICHER FROM THE 1210 01:11:56,545 --> 01:11:59,081 UNIVERSITY OF ARIZONA AND 1211 01:11:59,148 --> 01:12:05,320 RELIEVING CHRONIC PAIN VIA THEA 1212 01:12:05,587 --> 01:12:09,525 -- THE A2A RECEPTOR. 1213 01:12:09,591 --> 01:12:12,828 >> GOOD TO BE HERE WITH YOU IN 1214 01:12:12,895 --> 01:12:13,762 PERSON. 1215 01:12:13,829 --> 01:12:24,273 SIME I'VE FLOWN FOR YEARS. 1216 01:12:27,109 --> 01:12:31,447 SO WE'RE INTERESTED IN TERPENE 1217 01:12:31,513 --> 01:12:33,649 COMPOUNDS AS YOU ARE AND WE HAD 1218 01:12:33,716 --> 01:12:35,417 INTERESTED AND THEY HAD BEEN 1219 01:12:35,484 --> 01:12:39,855 REPORTED IN THE PRECLINICAL AND 1220 01:12:39,922 --> 01:12:40,989 CLINICAL LITERATURE BUT THERE'S 1221 01:12:41,056 --> 01:12:42,024 A MECHANISM WE WANTED TO DIG 1222 01:12:42,091 --> 01:12:44,059 INTO AND THE PRECURSOR TO OUR 1223 01:12:44,126 --> 01:12:51,633 FUNDED WORK WE FOUND THEY WERE 1224 01:12:51,700 --> 01:12:59,408 ALL PRODUCING BEHAVIORS AND 1225 01:12:59,475 --> 01:13:03,045 SYNERGIZED VIA THE RECEPTOR AND 1226 01:13:03,112 --> 01:13:08,550 WE WANTED TO EXTEND BEYOND THAT 1227 01:13:08,617 --> 01:13:19,128 AND AND AND WE WORKED THROUGH 1228 01:13:39,948 --> 01:13:43,719 THE RECEPTOR NOT THE CANNABINOID 1229 01:13:43,786 --> 01:13:45,554 1 RECEPTOR AND LINK THE 1230 01:13:45,621 --> 01:13:51,260 ACTIVATION OF THE RECEPTOR TO A 1231 01:13:51,326 --> 01:13:52,961 CIRCUIT. 1232 01:13:53,028 --> 01:13:58,200 WHAT WE FOUND TERPENES WERE 1233 01:13:58,267 --> 01:14:01,970 EFFICACIOUS IN THE PAIN AND USED 1234 01:14:02,037 --> 01:14:09,611 THE NEUROPATHY ABOUT EQUIVALENT 1235 01:14:09,678 --> 01:14:12,247 TO MORPHINE AND SAW THIS IN THE 1236 01:14:12,314 --> 01:14:13,982 RECEPTOR AND THE WORK GETS 1237 01:14:14,049 --> 01:14:15,717 PUBLISHED THIS YEAR. 1238 01:14:15,784 --> 01:14:19,288 IT'S A HUGE PAPER LIKE 21 1239 01:14:19,354 --> 01:14:19,521 FIGURES. 1240 01:14:19,588 --> 01:14:21,757 AT THE SAME TIME WE SHOWED IT 1241 01:14:21,824 --> 01:14:23,992 HAD A GOOD SIDE EFFECT PROFILE. 1242 01:14:24,059 --> 01:14:26,595 WE SHOWED KNOW ABUSE LIABILITY. 1243 01:14:26,662 --> 01:14:28,831 SOME TERPENES HAD NOR AVERSION 1244 01:14:28,897 --> 01:14:31,967 NOR REWARD WHICH IS WHAT YOU 1245 01:14:32,034 --> 01:14:33,602 WANT AND MODERATE TOLERANCE AND 1246 01:14:33,669 --> 01:14:36,972 THE ABILITY TO ENHANCE OPIOID 1247 01:14:37,039 --> 01:14:39,241 PAIN RELIEF AND USE THEM 1248 01:14:39,308 --> 01:14:41,143 TOGETHER YOU GET MORE PAIN 1249 01:14:41,210 --> 01:14:43,712 RELIEF THAN EITHER ALONE AND 1250 01:14:43,779 --> 01:14:44,479 THAT ENHANCEMENT BECOMES 1251 01:14:44,546 --> 01:14:50,919 INTERESTING WHEN YOU GET TO THE 1252 01:14:50,986 --> 01:14:51,553 UNPUBLISHED WORKED SHOWING IT 1253 01:14:51,620 --> 01:15:02,164 CAN BLOCK THE REWARD AND SHOWING 1254 01:15:04,733 --> 01:15:07,402 WHEN YOU COMBINE THEM YOU BLOCK 1255 01:15:07,469 --> 01:15:09,705 THAT DOPAMINE ACTIVITY. 1256 01:15:09,771 --> 01:15:11,340 WHEN YOU THINK OF THAT IN TERM 1257 01:15:11,406 --> 01:15:12,808 OF THIS ABILITY TO DO OPIOID 1258 01:15:12,875 --> 01:15:15,744 PAIN RELIEF IT SUGGESTS THE 1259 01:15:15,811 --> 01:15:16,778 PERFECT COMBINATION THERAPY AND 1260 01:15:16,845 --> 01:15:19,281 MAKE THE PAIN RELIEF BETTER AND 1261 01:15:19,348 --> 01:15:21,383 BLOCKING THE REWARD ASPECTS THE 1262 01:15:21,450 --> 01:15:23,118 OPIOIDS SO WE'RE EXCITED ABOUT 1263 01:15:23,185 --> 01:15:24,586 THAT. 1264 01:15:24,653 --> 01:15:28,490 WE'VE ALSO BEEN ABLE TO 1265 01:15:28,557 --> 01:15:31,493 VISUALIZE THE CIRCUITS AND 1266 01:15:31,560 --> 01:15:35,197 FIGURING OUT HOW TERPENES ACT TO 1267 01:15:35,264 --> 01:15:37,933 ACTIVATE NOCICEPTION AND WE'RE 1268 01:15:38,000 --> 01:15:40,435 LOOKING AT THE NEURONS HOPING TO 1269 01:15:40,502 --> 01:15:41,703 BE THE RIGHT MARKER AND HAVE 1270 01:15:41,770 --> 01:15:43,639 OTHER PROJECTS WE'VE BEEN 1271 01:15:43,705 --> 01:15:44,840 SUCCESSFUL WITH BUT DON'T HAVE 1272 01:15:44,907 --> 01:15:47,542 TIME TO TALK ABOUT AND WORK WITH 1273 01:15:47,609 --> 01:15:48,110 MINOR CANNABINOIDS. 1274 01:15:48,176 --> 01:15:50,946 THIS PAPER WAS JUST ACCEPTED FOR 1275 01:15:51,013 --> 01:15:51,713 PUBLICATION WEEKS AGO AND YOU'LL 1276 01:15:51,780 --> 01:15:59,087 BE SEEING THAT SOON AND THE 1277 01:15:59,154 --> 01:16:00,322 NON-TERPENE CANNABIS TYPES AND 1278 01:16:00,389 --> 01:16:01,890 THE NEXT STEPS, WE NEED TO WORK 1279 01:16:01,957 --> 01:16:04,626 MORE ON THE MECHANISM. 1280 01:16:04,693 --> 01:16:05,694 WE KNOW THROUGH THE RECEPTOR AND 1281 01:16:05,761 --> 01:16:09,765 WE FLOW THEY WORK THROUGH OTHER 1282 01:16:09,831 --> 01:16:11,767 RECEPTORS FROM THE TARGETS SOME 1283 01:16:11,833 --> 01:16:13,435 ION CHANNELS AND OTHER RECEPTOR 1284 01:16:13,502 --> 01:16:17,306 TYPES BUT THE MECHANISMS ARE 1285 01:16:17,372 --> 01:16:18,941 REALLY NOT CAREER. 1286 01:16:19,007 --> 01:16:20,676 WHERE ARE THE CIRCUITS AND 1287 01:16:20,742 --> 01:16:22,811 NEUROLOGICAL CHANGE AND AT THE 1288 01:16:22,878 --> 01:16:24,746 RECEPTOR WE'RE NOT HAD SURE 1289 01:16:24,813 --> 01:16:26,882 THEY'RE STANDARD AGONISTS AND WE 1290 01:16:26,949 --> 01:16:28,517 KNOW THERE'S OTHER MECHANISMS OF 1291 01:16:28,583 --> 01:16:30,852 ACTION BUT DON'T KNOW WHAT THAT 1292 01:16:30,919 --> 01:16:33,055 IS AND PUTTING IN FAIR EFFORT TO 1293 01:16:33,121 --> 01:16:34,656 FIGURE OUT HOW THAT THE 1294 01:16:34,723 --> 01:16:34,923 HAPPENING. 1295 01:16:34,990 --> 01:16:36,591 WE ALSO NEED TO COMPLETE OUR 1296 01:16:36,658 --> 01:16:37,426 THERAPEUTIC WORK. 1297 01:16:37,492 --> 01:16:41,196 ASK THE QUESTION WILL TERPENES 1298 01:16:41,263 --> 01:16:47,436 MAKE REAL DRUGS AND BLOCK 1299 01:16:47,502 --> 01:16:48,937 REWARDING AND OTHER SIDE EFFECTS 1300 01:16:49,004 --> 01:16:54,776 AND CAN WE REMEMBER THEM IN A 1301 01:16:54,843 --> 01:16:56,645 THERAPEUTICALLY USEFUL DOSE AND 1302 01:16:56,712 --> 01:16:58,013 THESE WILL BE SOME OF MY 1303 01:16:58,080 --> 01:16:59,481 THOUGHTS MAYBE WE CAN MAKE MORE 1304 01:16:59,548 --> 01:17:01,550 IN DETAIL. 1305 01:17:01,616 --> 01:17:02,851 DO TERPENES CONTRIBUTE TO THE 1306 01:17:02,918 --> 01:17:05,387 RECREATIONAL OR THERAPEUTIC 1307 01:17:05,454 --> 01:17:06,755 EFFECTS OF CANNABIS IS THAT 1308 01:17:06,822 --> 01:17:07,622 REAL? 1309 01:17:07,689 --> 01:17:12,494 I GET THAT ASKED A LOT. 1310 01:17:12,561 --> 01:17:13,595 SEVERAL TARGETS HAVE BEEN 1311 01:17:13,662 --> 01:17:15,197 REPORTED TO DATE AND THERE'S 1312 01:17:15,263 --> 01:17:16,631 BEEN A NUMBER INCLUDING ION 1313 01:17:16,698 --> 01:17:18,934 CHANNELS AND WHAT IS THE REAL 1314 01:17:19,001 --> 01:17:20,369 MECHANISM OF ACTION AND WE NEED 1315 01:17:20,435 --> 01:17:21,737 TO FIGURE THAT OUT AND A CONCERN 1316 01:17:21,803 --> 01:17:24,339 IS THE PUBLIC IS WIDELY USING 1317 01:17:24,406 --> 01:17:27,376 THE DRUGS AND MANY COMMERCIAL 1318 01:17:27,442 --> 01:17:30,579 ACTORS ARE AHEAD OF US AND TAKE 1319 01:17:30,645 --> 01:17:32,547 THIS AND IT WILL CURE YOUR 1320 01:17:32,614 --> 01:17:34,082 ANXIETY AND THIS MYRCENE WILL 1321 01:17:34,149 --> 01:17:35,917 MAKE YOU HAPPY AND CURE ALL YOUR 1322 01:17:35,984 --> 01:17:37,886 PROBLEMS AND THERE'S NO BACKING 1323 01:17:37,953 --> 01:17:41,556 FOR MOST OF THAT AND NEED TO TRY 1324 01:17:41,623 --> 01:17:44,092 TO GET AHEAD OF IT OR AT LEAST 1325 01:17:44,159 --> 01:17:46,828 CATCH UP AND INFORM THE PUBLIC 1326 01:17:46,895 --> 01:17:50,832 OF WHAT THESE DRUGS ARE DOING 1327 01:17:50,899 --> 01:17:52,834 AND MIGHT WE FACE HURDLES TO GET 1328 01:17:52,901 --> 01:17:55,003 THESE PATENTED AND IS THERE A 1329 01:17:55,070 --> 01:17:57,272 WAY TO SECURE INVESTMENT FUND 1330 01:17:57,339 --> 01:17:59,207 AND MAYBE NIH MAY HAVE A LEAD ON 1331 01:17:59,274 --> 01:17:59,408 THAT. 1332 01:17:59,474 --> 01:18:00,642 AND THERE'S A LOT OF WORK TO DO 1333 01:18:00,709 --> 01:18:01,743 BUT THESE ARE PEOPLE WHO DID ALL 1334 01:18:01,810 --> 01:18:02,477 THE WORK AND THANK YOU ALL FOR 1335 01:18:02,544 --> 01:18:08,984 YOUR ATTENTION. 1336 01:18:09,051 --> 01:18:11,219 >> THANK YOU VERY MUCH. 1337 01:18:11,286 --> 01:18:13,688 OUR NEXT SPEAKER IS DR. MACKIE 1338 01:18:13,755 --> 01:18:14,556 FROM INDIANA UNIVERSITY 1339 01:18:14,623 --> 01:18:19,161 PRESENTING ON MODULATION OF PAIN 1340 01:18:19,227 --> 01:18:19,795 MECHANISM BY CANNABIS DERIVED 1341 01:18:19,861 --> 01:18:20,062 CHEMICALS. 1342 01:18:20,128 --> 01:18:27,736 THANK YOU VERY MUCH. 1343 01:18:27,803 --> 01:18:31,706 >> GOOD MORNING, EVERYONE. 1344 01:18:31,773 --> 01:18:33,408 I'M HERE TO TALK ABOUT THE 1345 01:18:33,475 --> 01:18:36,845 PROJECT THE MULTI-PRI WE HAVE 1346 01:18:36,912 --> 01:18:41,917 WITH QUEENS MEDICAL CENTER IN 1347 01:18:41,983 --> 01:18:42,417 HAWAI'I. 1348 01:18:42,484 --> 01:18:43,718 AND THIS WAS A PROJECT THAT HAS 1349 01:18:43,785 --> 01:18:45,387 TWO PHASES. 1350 01:18:45,454 --> 01:18:51,426 THE FIRST PHASE WAS TO BROADLY 1351 01:18:51,493 --> 01:18:57,099 PROFILE MINOR CANNABINOIDS AS 1352 01:18:57,165 --> 01:19:00,802 WELL AS SOME MIXTURES AGAINST 1353 01:19:00,869 --> 01:19:05,607 THE ION CHANNELS PRESENT IN THE 1354 01:19:05,674 --> 01:19:08,009 IMMUNE CELLS AND AGAINST THE 1355 01:19:08,076 --> 01:19:11,046 NUMBER OF CELL LINES AND RATHER 1356 01:19:11,113 --> 01:19:12,380 LARGE MATRIX SCREENING. 1357 01:19:12,447 --> 01:19:14,349 THIS WORK WAS DONE BY THOSE 1358 01:19:14,416 --> 01:19:15,951 SITTING IN THE FRONT ROW AND CAN 1359 01:19:16,017 --> 01:19:17,085 ANSWER SPECIFIC QUESTIONS ABOUT 1360 01:19:17,152 --> 01:19:21,756 THIS PART OF THE WORK. 1361 01:19:21,823 --> 01:19:24,259 SO INHIBITING THE CALCIUM 1362 01:19:24,326 --> 01:19:26,228 CHANNELS MAY BE ANTIINFLAMMATORY 1363 01:19:26,294 --> 01:19:28,396 AND MAYBE THE COMPOUNDS WILL BE 1364 01:19:28,463 --> 01:19:30,098 USEFUL FOR TREATING VARIOUS PAIN 1365 01:19:30,165 --> 01:19:30,332 STATES. 1366 01:19:30,398 --> 01:19:32,200 THE SECOND PHASE OF THE STUDY 1367 01:19:32,267 --> 01:19:35,070 WAS TO TAKE THE MOST POTENT 1368 01:19:35,137 --> 01:19:37,606 COMPOUNDS AND TEST THEM IN PAIN 1369 01:19:37,672 --> 01:19:38,273 MODELS PARTICULARLY INFLAMMATORY 1370 01:19:38,340 --> 01:19:47,716 PAIN USING CFA AND PHARMACOLOGIC 1371 01:19:47,782 --> 01:19:50,085 NEUROPATHY USING THE MODEL. 1372 01:19:50,152 --> 01:19:57,626 SO THE PRIMARY FINDINGS FOR THE 1373 01:19:57,692 --> 01:19:59,127 ACIDIC CANNABINOIDS AND 1374 01:19:59,194 --> 01:20:02,097 INHIBITING THE CHANNELS AND CBGA 1375 01:20:02,164 --> 01:20:07,736 WAS POTENT IN THE LOW NANO MOLAR 1376 01:20:07,802 --> 01:20:12,807 RANGES AND THEN ALSO ANOTHER 1377 01:20:12,874 --> 01:20:17,078 TARGET WAS TRPM7 AND THIS 1378 01:20:17,145 --> 01:20:22,517 REQUIRED THE KINASE DOMAIN OF 1379 01:20:22,584 --> 01:20:25,954 TRPM7 AND PHOSPHORYLATION BY THE 1380 01:20:26,021 --> 01:20:26,188 KINASE. 1381 01:20:26,254 --> 01:20:30,258 IN LOOKING AT CBGA IT'S STRONGLY 1382 01:20:30,325 --> 01:20:32,827 ANTI-INFLAMMATORY IN TERMS OF 1383 01:20:32,894 --> 01:20:38,800 EXPRESSING IL2 PRODUCTION. 1384 01:20:38,867 --> 01:20:40,635 DESPITE THIS VERY GOOD IN VITRO 1385 01:20:40,702 --> 01:20:42,837 RESULTS, WE HAVE FOUND NO 1386 01:20:42,904 --> 01:20:48,310 EFFICACY IN OUR PAIN MODEL CFA 1387 01:20:48,376 --> 01:20:53,882 OR TREATING THE ESTABLISHED PAIN 1388 01:20:53,949 --> 01:20:58,353 OR USING IT IN A PROPHYLACTIC 1389 01:20:58,420 --> 01:20:59,487 MODE FOR MALES AND FEMALES AND 1390 01:20:59,554 --> 01:21:03,925 GOING UP TO HIGH DOSES WILL AT 1391 01:21:03,992 --> 01:21:06,428 30 MEGS PER KILO GRAM. 1392 01:21:06,494 --> 01:21:07,729 INTERESTINGLY THOUGH WE HAVEN'T 1393 01:21:07,796 --> 01:21:10,765 SEEN EFFICACY IN THE PAIN MODELS 1394 01:21:10,832 --> 01:21:13,768 CPG IS EFFICACIOUS IN TREATING 1395 01:21:13,835 --> 01:21:22,377 TWO MODELS OF KIDNEY DISEASE THE 1396 01:21:22,444 --> 01:21:24,079 CHEMOTHERAPY INDUCED MODEL AND 1397 01:21:24,145 --> 01:21:29,484 DOSE OF 10 MIGS PER KILOGRAM AND 1398 01:21:29,551 --> 01:21:31,786 IS NOT EFFECTIVE ON PAIN MODELS. 1399 01:21:31,853 --> 01:21:33,822 WE STRUGGLED WITH THIS QUITE A 1400 01:21:33,888 --> 01:21:34,889 BIT AND SOME OF THE REASONS WE 1401 01:21:34,956 --> 01:21:38,827 THINK FOR THE LACK OF EFFICACY 1402 01:21:38,893 --> 01:21:42,364 IN THE PAIN MODELS ARE POOR BIO 1403 01:21:42,430 --> 01:21:42,931 AVAILABILITY AND THESE 1404 01:21:42,998 --> 01:21:44,933 PARTICULAR PAIN MODELS MAY BE 1405 01:21:45,000 --> 01:21:48,203 LESS SUSCEPTIBLE TO THE 1406 01:21:48,270 --> 01:21:52,307 ANTI-INFLAMMATORY EFFECTS AND 1407 01:21:52,374 --> 01:21:56,711 ALL THE PAIN ASSAYS MAY NOT 1408 01:21:56,778 --> 01:21:57,312 REFLECT THE ANTI-INFLAMMATORY 1409 01:21:57,379 --> 01:22:02,417 PROCESS. 1410 01:22:02,484 --> 01:22:06,588 SO THE NEXT STEPS THINKING THE 1411 01:22:06,655 --> 01:22:08,556 CBG IS EFFECTIVE IN THE KIDNEY 1412 01:22:08,623 --> 01:22:10,792 MODELS AND MAYBE THE DOSING 1413 01:22:10,859 --> 01:22:12,060 PRESENCE QUESTIONS AND 1414 01:22:12,127 --> 01:22:15,330 APPLICATION OF CBGA IN CFA MODEL 1415 01:22:15,397 --> 01:22:18,433 AND TEST EFFICACY IN THE NERVE 1416 01:22:18,500 --> 01:22:19,100 INJURY MODEL THROUGH EVIDENCE 1417 01:22:19,167 --> 01:22:22,237 THAT INHIBITORS ARE PARTIALLY 1418 01:22:22,304 --> 01:22:27,442 IVE -- EFFECTIVE IN PART IN 1419 01:22:27,509 --> 01:22:31,146 MALES AND WORK ON THIS MAY BE 1420 01:22:31,212 --> 01:22:31,379 HELPFUL. 1421 01:22:31,446 --> 01:22:38,787 THIS IS KIND OF LED US TO A 1422 01:22:38,853 --> 01:22:43,091 PLASMA BINDING CANNABINOIDS AND 1423 01:22:43,158 --> 01:22:48,830 MORE DIRECTED METHODS OF THE TRP 1424 01:22:48,897 --> 01:22:56,004 CHANNELS AND THE TRPM7 PROJECT 1425 01:22:56,071 --> 01:22:58,940 HAS LOOKED AT THESE COMPOUNDS IN 1426 01:22:59,007 --> 01:23:04,546 TUMOR MODELS AND RESULTS IN 1427 01:23:04,612 --> 01:23:05,847 ADVANCING THESE. 1428 01:23:05,914 --> 01:23:07,882 WITH THAT THANK YOU AND MANY GO 1429 01:23:07,949 --> 01:23:12,520 ON TO THE NEXT ONE. 1430 01:23:12,587 --> 01:23:14,556 >> THANK YOU YOU, VERY MUCH. 1431 01:23:14,622 --> 01:23:17,525 NEXT SPEAKER IS DR. LAND FROM 1432 01:23:17,592 --> 01:23:19,728 UNIVERSITY OF WASHINGTON IN 1433 01:23:19,794 --> 01:23:23,198 SEATTLE. 1434 01:23:23,264 --> 01:23:23,732 THANK YOU. 1435 01:23:23,798 --> 01:23:34,309 PRESENTING ON CANNABIE WHERE 1436 01:23:41,816 --> 01:23:45,286 THEY'LL HAVE EFFICACY IN CHRONIC 1437 01:23:45,353 --> 01:23:48,156 PAIN. 1438 01:23:48,223 --> 01:23:50,859 >> OUR GOAL IN A MODEL OF 1439 01:23:50,925 --> 01:23:53,395 LIGATION CAN WE GIVE A CHRONIC 1440 01:23:53,461 --> 01:23:57,031 ADMINISTRATION USING A MODEL WE 1441 01:23:57,098 --> 01:23:59,667 DEVELOPED TO PRODUCE THESE HYPER 1442 01:23:59,734 --> 01:24:10,044 ANALGESIC EFFECTS. 1443 01:24:12,847 --> 01:24:17,485 AND THE AMYGDALA HAS SHOWN TO BE 1444 01:24:17,552 --> 01:24:18,486 DESENSITIZED TO PAIN AND 1445 01:24:18,553 --> 01:24:29,097 REGULATE SPINAL CONTROL OF PAIN. 1446 01:24:31,065 --> 01:24:35,036 AND STARTED WITH THIS MODEL OF 1447 01:24:35,103 --> 01:24:37,272 ANIMALS WITH ACCESS AND THESE 1448 01:24:37,338 --> 01:24:40,275 ARE THE TWO MOST INTERESTING 1449 01:24:40,341 --> 01:24:43,111 GROUPS AND WE GAVE TERPENES AND 1450 01:24:43,178 --> 01:24:44,779 GAVE IT HIT WITHOUT THE 1451 01:24:44,846 --> 01:24:48,116 PRE-TREATMENT OF TERPENES ALONE 1452 01:24:48,183 --> 01:24:51,252 AND GET LIGATION AT DAY ZERO AND 1453 01:24:51,319 --> 01:24:52,387 IN THE PURPLE GROUP THEY GET CBD 1454 01:24:52,454 --> 01:24:55,423 AND TERPENES AND THE CONTROL 1455 01:24:55,490 --> 01:24:57,292 ANIMALS RECEIVE CONTROL OF 1456 01:24:57,358 --> 01:24:59,694 GELATIN THE ENTIRE TIME. 1457 01:24:59,761 --> 01:25:03,998 YOU CAN SEE A NICE ANALGESIA IS 1458 01:25:04,065 --> 01:25:06,334 MAINTAINED FOR 21 DAYS WHEN WE 1459 01:25:06,401 --> 01:25:08,937 GIVE THE GELATINS THE DOSES WE 1460 01:25:09,003 --> 01:25:13,842 HAVE IN THERE WE COMPLETELY 1461 01:25:13,908 --> 01:25:22,383 BLOCK THE ANALGENEIC EFFECT AND 1462 01:25:22,450 --> 01:25:25,854 INTERESTING ONE THING WE FOUND 1463 01:25:25,920 --> 01:25:29,157 IS WHEN WE GIVE ACUTE CBD AND 1464 01:25:29,224 --> 01:25:31,926 TERPENES WE DON'T SEE THIS BLOCK 1465 01:25:31,993 --> 01:25:40,468 OF CHRONIC PAIN. 1466 01:25:40,535 --> 01:25:50,078 AND WHAT WE SEE IS ACUTE CBD 1467 01:25:50,144 --> 01:25:51,045 DOESN'T INHIBIT CHRONIC PAIN AND 1468 01:25:51,112 --> 01:25:53,214 IF YOU FOCUS ON THE UPPER LEFT 1469 01:25:53,281 --> 01:25:56,518 ONE OTHER THING WE'RE DOING IS 1470 01:25:56,584 --> 01:25:58,386 THIS REAL TIME CALCIUM IMAGING 1471 01:25:58,453 --> 01:26:01,623 IN THE BASAL LATERAL AMYGDALA 1472 01:26:01,689 --> 01:26:04,726 AND THE ANIMAL'S HEAD IS FIXED 1473 01:26:04,792 --> 01:26:08,396 AND WE'RE APPLYING A FILAMENT TO 1474 01:26:08,463 --> 01:26:19,007 THE BASE OF THE TAIL AND I WANT 1475 01:26:28,750 --> 01:26:31,185 TO DRAW YOUR ATTENTION TO THE 1476 01:26:31,252 --> 01:26:33,488 TOP LINE AND THE LEFT SET OF 1477 01:26:33,555 --> 01:26:35,723 DATA GOING DOWN TO HIGHLIGHT THE 1478 01:26:35,790 --> 01:26:38,960 FACT THE NEURONS OF THE BLA 1479 01:26:39,027 --> 01:26:41,462 SCALE WITH THE WEIGHT AND THE 1480 01:26:41,529 --> 01:26:44,966 LIGHTER WEIGHTS ON THE LEFT YOU 1481 01:26:45,033 --> 01:26:45,667 DON'T GET AS MUCH AS A RESPONSE 1482 01:26:45,733 --> 01:26:47,702 AND OVER TIME YOU SEE THE 1483 01:26:47,769 --> 01:26:52,774 DEVELOPMENT OF A STRONGER 1484 01:26:52,840 --> 01:27:03,151 RESPONSE TO THAT. 1485 01:27:05,820 --> 01:27:08,022 AND WE'RE NOT SEEING THE EFFECTS 1486 01:27:08,089 --> 01:27:13,628 ON BEHAVIOR. 1487 01:27:13,695 --> 01:27:15,730 AND ONLY CHRONIC DOSING IN THIS 1488 01:27:15,797 --> 01:27:24,305 COMBINATION PROVIDES BENEFIT. 1489 01:27:24,372 --> 01:27:28,576 WE'RE TRYING TO LOOK AT MORE 1490 01:27:28,643 --> 01:27:32,780 BEHAVIORAL PAIN PROFILE AND WE 1491 01:27:32,847 --> 01:27:34,148 HAVE THIS MACHINE LEARNING MODEL 1492 01:27:34,215 --> 01:27:36,684 WHERE THE MACHINE LEARNING IS 1493 01:27:36,751 --> 01:27:37,852 TRAINED TO STAMP ALL THE SPOTS 1494 01:27:37,919 --> 01:27:39,654 ON THE MOUSE AND THE MOUSE DOES 1495 01:27:39,721 --> 01:27:41,623 ALL THESE BEHAVIORS AND WE CAN 1496 01:27:41,689 --> 01:27:43,925 MEASURE THESE IN THE LINEAR 1497 01:27:43,992 --> 01:27:45,994 TRACK IN AN UNBIASSED WAY AND 1498 01:27:46,060 --> 01:27:48,663 WHAT WE GET WITH THAT IS JUST A 1499 01:27:48,730 --> 01:27:49,530 HUGE AMOUNT OF DATA. 1500 01:27:49,597 --> 01:27:52,967 THESE ARE ANIMALS THAT AT 1501 01:27:53,034 --> 01:27:54,202 BASELINE AND DAY ONE AND DAY 12 1502 01:27:54,268 --> 01:27:57,939 OF CHRONIC PAIN AND YOU SEE A 1503 01:27:58,006 --> 01:28:00,108 VARIETY OF METRICS CHANGE AS A 1504 01:28:00,174 --> 01:28:01,109 RESULT OF CHRONIC PAIN AND HOW 1505 01:28:01,175 --> 01:28:02,010 MUCH THEY MOVE. 1506 01:28:02,076 --> 01:28:04,679 WE THINK THIS IS LIKE GIVING US 1507 01:28:04,746 --> 01:28:06,848 A WIDER BEHAVIORAL PROFILE TO 1508 01:28:06,914 --> 01:28:09,183 USE WITH VON FREY AND HOT PLATE. 1509 01:28:09,250 --> 01:28:12,320 AND WE CAN GENERATE WHAT WE CALL 1510 01:28:12,387 --> 01:28:13,855 RADAR PLOTS THOUGH I THINK THEY 1511 01:28:13,921 --> 01:28:15,456 CAN BE REFINED A LITTLE BIT AND 1512 01:28:15,523 --> 01:28:18,126 GIVING US WHAT QUOTE, UNQUOTE, 1513 01:28:18,192 --> 01:28:19,093 FINGERPRINT OF WHAT THIS CHRONIC 1514 01:28:19,160 --> 01:28:20,628 PAIN LOOKS LIKE AND THE DASH 1515 01:28:20,695 --> 01:28:27,068 LINE IS 100% AND THESE ARE HOW 1516 01:28:27,135 --> 01:28:30,171 THE METRICS CHANGE AT DAY ONE 1517 01:28:30,238 --> 01:28:35,710 AND WHEN WE GIVE THE ACUTE 1518 01:28:35,777 --> 01:28:46,220 TREATMENT CBD YOU SEE THE 1519 01:28:52,727 --> 01:28:53,928 RECOVERY TO THE DASH LINE AND 1520 01:28:53,995 --> 01:28:54,896 WE'RE COLLABORATING WITH GROUPS 1521 01:28:54,962 --> 01:28:56,798 THAT WOULD LIKE TO TRY THE 1522 01:28:56,864 --> 01:28:58,066 LINEAR TRACK FOR THE BEHAVIORAL 1523 01:28:58,132 --> 01:29:01,836 MODELS SO COME AND TALK TO ME IF 1524 01:29:01,903 --> 01:29:05,907 YOU'RE INTERESTED. 1525 01:29:05,973 --> 01:29:07,675 THANKS. 1526 01:29:07,742 --> 01:29:08,342 >> WONDERFUL. 1527 01:29:08,409 --> 01:29:08,609 THANK YOU. 1528 01:29:08,676 --> 01:29:10,545 THANK YOU, DR. LAND. 1529 01:29:10,611 --> 01:29:15,717 OUR NEXT SPEAKER IS DR. VRANA 1530 01:29:15,783 --> 01:29:19,721 FROM PENNSYLVANIA STATE 1531 01:29:19,787 --> 01:29:23,891 UNIVERSITY PRESENTING ON 1532 01:29:23,958 --> 01:29:24,859 A.I.-BASED MAPPING CANNABIS 1533 01:29:24,926 --> 01:29:27,695 EXTRACTS IN PAIN PATHWAYS. 1534 01:29:27,762 --> 01:29:29,597 >> THANK YOU FOR THE OPPORTUNITY 1535 01:29:29,664 --> 01:29:33,634 I'M HERE REPRESENTING AN MPI 1536 01:29:33,701 --> 01:29:36,104 PROPOSAL WITH MY P.I. IN 1537 01:29:36,170 --> 01:29:37,371 RESEARCH. 1538 01:29:37,438 --> 01:29:42,343 THE GOAL IS TO USE AN AND 1539 01:29:42,410 --> 01:29:44,846 ARTIFICIAL INTELLIGENCE, MACHINE 1540 01:29:44,912 --> 01:29:45,747 LEARNING MECHANISM MAPPING 1541 01:29:45,813 --> 01:29:48,750 COMPOUNDS TO TARGETS NOT JUST 1542 01:29:48,816 --> 01:29:50,518 CANNABINOIDS BUT IN THIS WE'RE 1543 01:29:50,585 --> 01:29:54,288 FOCUSSED ON CANNABINOIDS AND WE 1544 01:29:54,355 --> 01:29:55,356 HAVE A LARGE TEAM WITH US 1545 01:29:55,423 --> 01:29:55,923 SEVERAL OF WHOM ARE WITH US 1546 01:29:55,990 --> 01:30:05,366 TODAY. 1547 01:30:05,433 --> 01:30:06,501 SO BENJAMIN SET THIS UP WELL. 1548 01:30:06,567 --> 01:30:10,471 THIS WAS A PAPER PUBLISHED IN 1549 01:30:10,538 --> 01:30:11,672 OCTOBER INVOLVING CHRONIC 1550 01:30:11,739 --> 01:30:15,877 ADMINISTRATION OF CBG AND IT'S 1551 01:30:15,943 --> 01:30:20,948 PROVIDING 24-7 ANALGESIA AND WE 1552 01:30:21,015 --> 01:30:23,718 USE THE IP ADMINISTRATION NOT 1553 01:30:23,785 --> 01:30:24,919 THE GELATIN ADMINISTRATION BUT 1554 01:30:24,986 --> 01:30:26,454 WE'RE MOVING THAT WAY NOW. 1555 01:30:26,521 --> 01:30:31,058 WE DO SEE ACUTE EFFECTS OF CPG 1556 01:30:31,125 --> 01:30:33,261 AS AN ANALGESIC HOWEVER, WHAT'S 1557 01:30:33,327 --> 01:30:36,497 REMARKABLE IS WHEN WE GIVE IT TO 1558 01:30:36,564 --> 01:30:37,532 MALES AND FEMALES CHRONICALLY 1559 01:30:37,598 --> 01:30:41,002 OVER THE COURSE OF 7 OR 14 DAYS 1560 01:30:41,068 --> 01:30:47,275 WE SEE HERE'S THE PRE-TREATMENT 1561 01:30:47,341 --> 01:30:48,442 STATE, THE NEUROPATHIC STATE AND 1562 01:30:48,509 --> 01:30:51,445 SEE A RELIEF FROM THAT. 1563 01:30:51,512 --> 01:30:53,681 ACUTELY, THAT RELIEF IS ALMOST 1564 01:30:53,748 --> 01:30:53,881 100%. 1565 01:30:53,948 --> 01:30:55,049 WE DON'T ACHIEVE THAT BUT HERE'S 1566 01:30:55,116 --> 01:30:56,884 THE KEY. 1567 01:30:56,951 --> 01:31:00,188 THE DRUG WAS GIVEN 24 HOURS 1568 01:31:00,254 --> 01:31:02,456 PRIOR TO THE TEST. 1569 01:31:02,523 --> 01:31:03,724 WE'RE GETTING MODEST AND GEESH 1570 01:31:03,791 --> 01:31:10,765 YA -- ANALGESIA AND WE ARE 1571 01:31:10,832 --> 01:31:13,868 BEGINNING TO EXPLORE CLINICAL 1572 01:31:13,935 --> 01:31:16,838 TRIAL IN A CANCER MODEL -- 1573 01:31:16,904 --> 01:31:19,707 CANCER TREATMENT IN HUMANS THAT 1574 01:31:19,774 --> 01:31:20,975 GENERATES CIPN. 1575 01:31:21,042 --> 01:31:23,277 THE SECOND PAPER WE JUST 1576 01:31:23,344 --> 01:31:30,084 PUBLISHED IN DECEMBER COMES FROM 1577 01:31:30,151 --> 01:31:33,120 SOME WHO COULDN'T JOIN US AND 1578 01:31:33,187 --> 01:31:33,788 THE DIRECTOR OF MY CANNABIS 1579 01:31:33,855 --> 01:31:35,890 CENTER IN THE BACK OF THE ROOM 1580 01:31:35,957 --> 01:31:39,727 AND THE DRIFT PROGRAM COMPARES 1581 01:31:39,794 --> 01:31:42,063 DIFFERENT CANNABINOIDS AND 1582 01:31:42,129 --> 01:31:42,997 TERPENES PREDICT THE TARGETS 1583 01:31:43,064 --> 01:31:44,899 THEY'LL HIT AND ASKING IF 1584 01:31:44,966 --> 01:31:47,535 THEY'RE SIMILAR OR DIFFERENT IN 1585 01:31:47,602 --> 01:31:48,302 THE TARGETS? 1586 01:31:48,369 --> 01:31:51,305 OBVIOUSLY THC AND THCV WHICH 1587 01:31:51,372 --> 01:31:54,475 VARY IN A CARBON LENGTH ON THE 1588 01:31:54,542 --> 01:31:58,145 TAIL ARE HIGHLY CORRELATED. 1589 01:31:58,212 --> 01:32:01,649 SO THE PEARSON CORRELATION 1590 01:32:01,716 --> 01:32:03,651 COEFFICIENT BUT IN THE 1591 01:32:03,718 --> 01:32:04,252 PRELIMINARY SCREENING CPC IS 1592 01:32:04,318 --> 01:32:04,919 DIFFERENT FROM OTHER MOLECULES 1593 01:32:04,986 --> 01:32:09,190 AND THOUGHT IT MAY HAVE A UNIQUE 1594 01:32:09,257 --> 01:32:10,992 CHEMICAL BIOLOGICAL PROFILE AND 1595 01:32:11,058 --> 01:32:14,595 TURNED OUT TO BE THE CASE AND 1596 01:32:14,662 --> 01:32:24,038 WHILE CBD AND CBG LOOK SIMILAR 1597 01:32:24,105 --> 01:32:33,814 CBC PROVIDES ANALGESIA AND 1598 01:32:33,881 --> 01:32:35,950 INFLAMMATORY PAIN USING THE 1599 01:32:36,017 --> 01:32:36,350 MODEL. 1600 01:32:36,417 --> 01:32:40,221 WE THINK CBC HAS POTENTIAL AS A 1601 01:32:40,288 --> 01:32:50,765 NOVEL CANNABINOID FOR PAIN. 1602 01:32:57,939 --> 01:33:02,209 AND THIS IS AVAILABLE NOW AND 1603 01:33:02,276 --> 01:33:10,051 IT'S CANDY DOT D-O-K-H.org. 1604 01:33:10,117 --> 01:33:11,052 THEY'RE STILL IN REFINEMENT BUT 1605 01:33:11,118 --> 01:33:15,389 HERE'S THE IDEA. 1606 01:33:15,456 --> 01:33:17,792 WE HAVE PERHAPS DOZENS OF HEMP 1607 01:33:17,858 --> 01:33:23,364 EXTRACTS WITH DIFFERENT PROFILES 1608 01:33:23,431 --> 01:33:33,941 IN CBC, CBG AN THEY TAKE THE 1609 01:33:39,080 --> 01:33:40,614 LIBRARY OF EXTRACTS AND MINES 1610 01:33:40,681 --> 01:33:43,017 THE TEXT WITHIN PUB MED AND THE 1611 01:33:43,084 --> 01:33:44,885 PUBLICALLY AVAILABLE DATABASES 1612 01:33:44,952 --> 01:33:45,987 TO USE ARTIFICIAL INTELLIGENCE 1613 01:33:46,053 --> 01:33:48,089 TO START MAKING PREDICTIONS. 1614 01:33:48,155 --> 01:33:49,857 AND WHERE WE WOULD WANT TO BE IN 1615 01:33:49,924 --> 01:33:54,328 A COUPLE OF YEARS IS THAT RATHER 1616 01:33:54,395 --> 01:33:56,263 THAN AN EARLIER COMMENT TAKE 1617 01:33:56,330 --> 01:33:58,766 MYRCENE IT WILL TAKE YOU HAPPY 1618 01:33:58,833 --> 01:34:02,370 WE'LL HAVE PROFILES OF ENTOURAGE 1619 01:34:02,436 --> 01:34:03,704 EFFECTS TO LOOK AT WHAT 1620 01:34:03,771 --> 01:34:04,939 CONDITIONS SHOULD BE TREATED 1621 01:34:05,006 --> 01:34:06,607 WITH WHICH EXTRACT. 1622 01:34:06,674 --> 01:34:08,509 WE EXCITED ABOUT THIS. 1623 01:34:08,576 --> 01:34:09,577 I UNDERSTAND THE PUBLICATION HAS 1624 01:34:09,643 --> 01:34:10,945 NEARLY COME OUT NOW. 1625 01:34:11,012 --> 01:34:12,346 I'LL POINT OUT THESE ARE THE 1626 01:34:12,413 --> 01:34:15,116 PAPERS THAT WERE PUBLISHED IN 1627 01:34:15,182 --> 01:34:15,850 THE PAST YEAR SINCE LAST JULY 1628 01:34:15,916 --> 01:34:24,658 AND THANK YOU FOR YOUR TIME. 1629 01:34:24,725 --> 01:34:25,126 THANK YOU. 1630 01:34:25,192 --> 01:34:26,594 THIS IS VERY EXCITING. 1631 01:34:26,660 --> 01:34:31,098 THE NEXT PRESENTER IS FROM 1632 01:34:31,165 --> 01:34:34,001 OREGON STATE UNIVERSITY, 1633 01:34:34,068 --> 01:34:39,173 DR. STEVENS ON DISCOVERY OF 1634 01:34:39,240 --> 01:34:43,711 CANNABINOIDS FROM HEMP. 1635 01:34:43,778 --> 01:34:46,480 6: 1636 01:34:48,315 --> 01:34:49,083 >> THANK YOU VERY MUCH. 1637 01:34:49,150 --> 01:34:51,218 CAN YOU HEAR ME IN THE BACK? 1638 01:34:51,285 --> 01:34:58,726 >> PRESS THE BIG BUTTON. 1639 01:34:58,793 --> 01:35:02,863 >> SO OUR PROJECTI PROJECT IS ON 1640 01:35:02,930 --> 01:35:04,698 ASSISTED DISCOVERY OF 1641 01:35:04,765 --> 01:35:06,901 CANNABINOIDS FROM THE HEMP. 1642 01:35:06,967 --> 01:35:08,769 OREGON IS A BIG STATE AND IN 1643 01:35:08,836 --> 01:35:11,972 EAST OREGON THERE'S BIG PHARM 1644 01:35:12,039 --> 01:35:14,975 AND THEY EXTRACT CBD FROM THE 1645 01:35:15,042 --> 01:35:19,613 HEMP AND DISTILL IT ON A BIG 1646 01:35:19,680 --> 01:35:23,384 SCALE AND ISOLATE CBD AND CBG ON 1647 01:35:23,451 --> 01:35:25,319 A COMMERCIAL SCALE AND SELL TO 1648 01:35:25,386 --> 01:35:25,853 PHARMACEUTICAL COMPANIES. 1649 01:35:25,920 --> 01:35:27,721 THEN THEY CRYSTALIZE THOSE 1650 01:35:27,788 --> 01:35:29,590 MATERIALS AND WHAT'S LEFT OVER 1651 01:35:29,657 --> 01:35:35,096 WE CALL IN CHEMISTRY THE MOTHER 1652 01:35:35,162 --> 01:35:35,596 LIQUOR. 1653 01:35:35,663 --> 01:35:36,063 THE STUDENTS LAUGH. 1654 01:35:36,130 --> 01:35:40,067 IT HAS NOTHING TO DO WITH MOTHER 1655 01:35:40,134 --> 01:35:44,772 OR LIQUOR BUT IT'S A RICH SOURCE 1656 01:35:44,839 --> 01:35:45,439 OF CANNABINOIDS. 1657 01:35:45,506 --> 01:35:50,277 THEY USE THOSE MATERIALS TO DO 1658 01:35:50,344 --> 01:35:55,549 OUR IN VITRO STUDIES ON BIO 1659 01:35:55,616 --> 01:35:59,720 ACTIVE IN CELL CULTURE ANYTHING 1660 01:35:59,787 --> 01:36:05,192 RELATED TO PAIN PERCEPTION AND 1661 01:36:05,259 --> 01:36:08,229 LOOK AT CANNABINOIDS IN THE 1662 01:36:08,295 --> 01:36:10,397 ASSAYS AND WELL USE MACHINE 1663 01:36:10,464 --> 01:36:11,098 LEARNING. 1664 01:36:11,165 --> 01:36:13,868 HOW DOES THAT WORK? 1665 01:36:13,934 --> 01:36:20,174 WE FIRST HAVE A CLASSIC CALL. 1666 01:36:20,241 --> 01:36:26,814 ONE COLUMN SEPARATION STEP AND 1667 01:36:26,881 --> 01:36:30,885 OUR MACHINE LEARNING CAN DO 1668 01:36:30,951 --> 01:36:33,287 PREDICTION AND IN THE FRACTIONS 1669 01:36:33,354 --> 01:36:36,624 WE DO NOT ARE CONCERNED THESE 1670 01:36:36,690 --> 01:36:37,858 THINGS APPEAR. 1671 01:36:37,925 --> 01:36:40,194 YOU CAN SEE IN THE HEAT MAP HERE 1672 01:36:40,261 --> 01:36:42,897 AND EVERY FRACTION THAT IS 1673 01:36:42,963 --> 01:36:43,497 DIFFERENT CONCENTRATION AND 1674 01:36:43,564 --> 01:36:46,600 COMPOUNDS IS ENOUGH TO DO OUR 1675 01:36:46,667 --> 01:36:47,468 MACHINE LEARNING. 1676 01:36:47,535 --> 01:36:50,771 THEN FROM THOSE FRACTIONS YOU 1677 01:36:50,838 --> 01:36:54,942 HAVE A MASS SPECTRUM AND YOU CAN 1678 01:36:55,009 --> 01:36:57,411 SEE THE FRACTIONS AND PEAKS IN 1679 01:36:57,478 --> 01:36:59,680 THAT HEAT MAP AND THEN WE DO THE 1680 01:36:59,747 --> 01:37:03,717 BIO ASSAY AND CAN BE ANY BIO 1681 01:37:03,784 --> 01:37:07,087 ASSAY AND HERE'S THE EXAMPLE AND 1682 01:37:07,154 --> 01:37:08,656 THERE'S FLUCTUATIONS ACROSS THE 1683 01:37:08,722 --> 01:37:09,690 FRACTIONS. 1684 01:37:09,757 --> 01:37:12,760 THEN WE COMBINE THOSE TWO DATA 1685 01:37:12,826 --> 01:37:14,528 SETS AND DO PREDICTIONS. 1686 01:37:14,595 --> 01:37:18,999 YOU CAN SEE ON THE BLOCK ON THE 1687 01:37:19,066 --> 01:37:22,002 BOTTOM THAT THERE ARE ABOUT 10 1688 01:37:22,069 --> 01:37:25,072 MAYBE 15 COMPOUNDS IN THAT VERY 1689 01:37:25,139 --> 01:37:27,241 COMPLEX MIXTURE THAT PREDICTS 1690 01:37:27,308 --> 01:37:29,276 THE ACTIVITY IN THAT BIO ASSAY. 1691 01:37:29,343 --> 01:37:33,781 YOU CAN SEE IN THE TOP PREDICT 1692 01:37:33,847 --> 01:37:39,653 CDC8 AND ALL OTHER ASSAYS. 1693 01:37:39,720 --> 01:37:43,691 WHEN I PRESENT THE RESULTS I GET 1694 01:37:43,757 --> 01:37:46,827 THE COMPLAINTS YOU WILL ALWAYS 1695 01:37:46,894 --> 01:37:48,796 GET A TOP 10, I AGREE. 1696 01:37:48,862 --> 01:37:51,532 BUT IF YOU SCRAMBLE THE DATA AND 1697 01:37:51,599 --> 01:37:53,300 DISCONNECT THE BIO ACTIVITY DATA 1698 01:37:53,367 --> 01:37:55,302 FROM THE CHEM DATA YOU'LL SEE 1699 01:37:55,369 --> 01:37:56,870 THE RED LINE HERE AND THEN 1700 01:37:56,937 --> 01:38:02,509 COMPLETELY MOVE THE PREDICTIVE 1701 01:38:02,576 --> 01:38:03,077 EFFECTS. 1702 01:38:03,143 --> 01:38:08,082 SO THIS MEANS THIS WORKS AND NOW 1703 01:38:08,148 --> 01:38:11,719 WE CAN USE THOSE PREDICTORS IN 1704 01:38:11,785 --> 01:38:15,556 VALIDATION ASSAYS AND PUBLISH 1705 01:38:15,623 --> 01:38:17,191 ONE PAPER MAYBE TWO YEARS AGO 1706 01:38:17,258 --> 01:38:19,727 AND IT PREDICTS THE BIO ACTIVE 1707 01:38:19,793 --> 01:38:23,597 COMPOUND IN THE HOPS. 1708 01:38:23,664 --> 01:38:24,431 LAST SLIDE HERE. 1709 01:38:24,498 --> 01:38:26,600 SO WE HAVE THE PIPELINE 1710 01:38:26,667 --> 01:38:27,201 DEVELOPED. 1711 01:38:27,268 --> 01:38:31,705 WE WILL NOW ALSO WORK WITH THE 1712 01:38:31,772 --> 01:38:33,207 CBG DEPLETED FRACTIONS IN THE 1713 01:38:33,274 --> 01:38:39,146 SAME AIM SO THE BIO ACTIVITY 1714 01:38:39,213 --> 01:38:43,651 ASSAYS RELEVANT TO PAIN 1715 01:38:43,717 --> 01:38:45,586 PERCEPTION AND THEN WE STILL 1716 01:38:45,653 --> 01:38:47,121 NEED TO WORK ON THE CHEMISTRY 1717 01:38:47,187 --> 01:38:49,423 BECAUSE THERE'S HUNDREDS OF 1718 01:38:49,490 --> 01:38:50,891 COMPOUNDS AND WE HAVE ABOUT 35 1719 01:38:50,958 --> 01:38:51,859 STANDARDS IN HAND AND YOU CAN 1720 01:38:51,925 --> 01:38:52,159 SEE IN THE 1721 01:38:54,194 --> 01:38:57,398 GMPS NETWORK WE CAN IDENTIFY A 1722 01:38:57,464 --> 01:39:01,435 BUNCH OF COMPOUNDS BUT THERE'S 1723 01:39:01,502 --> 01:39:02,403 STILL MANY CANNABINOIDS WE DON'T 1724 01:39:02,469 --> 01:39:05,272 KNOW THE STRUCTURE OF AND MAYBE 1725 01:39:05,339 --> 01:39:07,908 THIS WILL HELP US TO IDENTIFY 1726 01:39:07,975 --> 01:39:11,879 NOVEL COMPOUNDS. 1727 01:39:11,945 --> 01:39:14,248 AND WE WORK WITH A BOTANICAL 1728 01:39:14,315 --> 01:39:17,551 CENTER IN OREGON TO DEVELOP THE 1729 01:39:17,618 --> 01:39:19,353 CANNABIS DATABASE AND HE STARTED 1730 01:39:19,420 --> 01:39:23,290 THAT BUT IT'S STILL NOT COMPLETE 1731 01:39:23,357 --> 01:39:25,459 AND WE WANT TO FILL THE 1732 01:39:25,526 --> 01:39:26,927 DATABASE. 1733 01:39:26,994 --> 01:39:31,432 WE HAVE A MOUSE MODEL AND 1734 01:39:31,498 --> 01:39:33,033 NON-INVASIVE USING ACOUSTICS AND 1735 01:39:33,100 --> 01:39:37,471 THIS IS SOMETHING WE DO WITH THE 1736 01:39:37,538 --> 01:39:39,206 COLLEGE OF ENGINEERING WHEN YOU 1737 01:39:39,273 --> 01:39:43,544 PUT A MOUSE IN A BOX IN PAIN 1738 01:39:43,610 --> 01:39:44,545 THEY BREATHE DIFFERENTLY AND 1739 01:39:44,611 --> 01:39:45,579 MAKE DIFFERENT SOUNDS AND 1740 01:39:45,646 --> 01:39:46,680 INSTEAD OF MAKING MOUSE AND PUT 1741 01:39:46,747 --> 01:39:49,883 IT IN THE SYSTEM YOU CAN MONITOR 1742 01:39:49,950 --> 01:39:52,953 WHILE THEY'RE LIVING IN THE CAGE 1743 01:39:53,020 --> 01:39:54,822 AND IT STILL NEEDS TO TO SOME 1744 01:39:54,888 --> 01:39:57,725 VALIDATION FOR US BUT IT WOULD 1745 01:39:57,791 --> 01:40:00,928 BE A GOOD WAY TO HAVE TOP 1746 01:40:00,994 --> 01:40:02,129 PREDICTORS AND TEST THEM IN A 1747 01:40:02,196 --> 01:40:07,134 WAY THAT MODEL TO SEE IF THERE 1748 01:40:07,201 --> 01:40:10,871 IS ANY EFFECT OF CANNABINOIDS ON 1749 01:40:10,938 --> 01:40:12,906 PAIN AND THAT'S MY PRESENTATION. 1750 01:40:12,973 --> 01:40:13,974 THANK YOU FOR YOUR ATTENTION. 1751 01:40:14,041 --> 01:40:16,744 >> THIS IS FANTASTIC. 1752 01:40:16,810 --> 01:40:18,278 THANK YOU, DR. STEVENS. 1753 01:40:18,345 --> 01:40:19,813 THE LAST PRESENTATION FOR THIS 1754 01:40:19,880 --> 01:40:22,116 PORTION IS DR. LOVE FROM 1755 01:40:22,182 --> 01:40:22,716 UNIVERSITY OF CALIFORNIA SAN 1756 01:40:22,783 --> 01:40:23,717 DIEGO. 1757 01:40:23,784 --> 01:40:26,520 THANK YOU. 1758 01:40:26,587 --> 01:40:29,189 PRESENTING ON MECHANISMS OF 1759 01:40:29,256 --> 01:40:33,961 MINOR CANNABINOIDS. 1760 01:40:34,027 --> 01:40:35,696 >> HI, EVERYONE. 1761 01:40:35,763 --> 01:40:40,968 I'M ANNA A POSTDOC IN PROFESSOR 1762 01:40:41,034 --> 01:40:44,405 BRAD MOORE'S LAB AT UCSD 1763 01:40:44,471 --> 01:40:45,406 REPRESENTING OUR MULTI-P.I. 1764 01:40:45,472 --> 01:40:46,974 PROGRAM. 1765 01:40:47,040 --> 01:40:49,476 A RECENTLY FUNDED R01 BETWEEN 1766 01:40:49,543 --> 01:40:51,245 THE MOORE LAB AND PROFESSOR 1767 01:40:51,311 --> 01:40:53,814 CHUNG'S LAB AT THE MEDICAL 1768 01:40:53,881 --> 01:40:54,515 DISCOVERY INSTITUTE. 1769 01:40:54,581 --> 01:40:59,420 SAN DIEGO'S A VERY RICH AREA FOR 1770 01:40:59,486 --> 01:41:00,254 ACADEMIC AND INDUSTRIAL BIO 1771 01:41:00,320 --> 01:41:02,756 TECHNOLOGY OUR LABS ARE A 10 1772 01:41:02,823 --> 01:41:04,391 MINUTE DRIVE AWAY WHICH HAS 1773 01:41:04,458 --> 01:41:05,592 HELPED FOSTER THIS 1774 01:41:05,659 --> 01:41:05,926 COLLABORATION. 1775 01:41:05,993 --> 01:41:10,164 OUR AWARD WAS FOUNDED ON 1776 01:41:10,230 --> 01:41:15,002 DECEMBER 20, 2023 AND THE FIRST 1777 01:41:15,068 --> 01:41:17,771 AIM IS TO DISCOVER AND 1778 01:41:17,838 --> 01:41:19,706 CHARACTERIZE NEW BIO CATALYSTS 1779 01:41:19,773 --> 01:41:22,242 TO CONSTRUCT THE DIVERSE MINOR 1780 01:41:22,309 --> 01:41:23,277 CANNABINOIDS AND THEN IN AIM 2 1781 01:41:23,343 --> 01:41:26,947 WE'RE LOOKING AT THE 1782 01:41:27,014 --> 01:41:28,882 NON-CLASSICAL AND CLASSICAL 1783 01:41:28,949 --> 01:41:29,516 CANNABINOID RECEPTOR COMPOUNDS 1784 01:41:29,583 --> 01:41:32,753 WE'RE GENERATING IN AIM 1. 1785 01:41:32,820 --> 01:41:35,689 THERE'S SYNERGY THAT HELP INFORM 1786 01:41:35,756 --> 01:41:37,224 EACH OTHER AND WE CAN GO BACK 1787 01:41:37,291 --> 01:41:42,696 AND GENERATE NEW LIBRARIES OF 1788 01:41:42,763 --> 01:41:42,996 MOLECULES. 1789 01:41:43,063 --> 01:41:43,997 SO OUR INTERESTING RESULTS, WE 1790 01:41:44,064 --> 01:41:45,432 HAVE A PAPER OUT THOUGH THE 1791 01:41:45,499 --> 01:41:47,334 AWARD WAS RECENTLY FUNDED. 1792 01:41:47,401 --> 01:41:49,503 WE HAVE A PAPER OUT EARLIER THIS 1793 01:41:49,570 --> 01:41:50,471 YEAR AND YOU MIGHT BE ASKING 1794 01:41:50,537 --> 01:41:53,307 WHAT DOES THE OCEAN HAVE TO DO 1795 01:41:53,373 --> 01:41:54,508 WITH CANNABIS BUT THIS WAS 1796 01:41:54,575 --> 01:41:56,643 SPAWNED FROM A RECENT DISCOVERY 1797 01:41:56,710 --> 01:41:58,979 IN BRAD MOORE'S LAB WE FOUND THE 1798 01:41:59,046 --> 01:42:02,149 MARINE BACTERIAL ENZYMES 1799 01:42:02,216 --> 01:42:05,486 INVOLVED IN THE BIO SYNTHESIS OF 1800 01:42:05,552 --> 01:42:07,588 ANTIBIOTICS AND FORM THE SAME 1801 01:42:07,654 --> 01:42:09,756 REACTIVE INTERMEDIATE FORMED BY 1802 01:42:09,823 --> 01:42:10,891 THE ENZYMES IN THE CANNABIS 1803 01:42:10,958 --> 01:42:11,191 PLANT. 1804 01:42:11,258 --> 01:42:14,194 YOU CAN SEE HERE ON THE TOP LEFT 1805 01:42:14,261 --> 01:42:16,029 THE MARINE BACTERIAL ENZYMES ARE 1806 01:42:16,096 --> 01:42:19,700 ABLE TO GENERATE THIS REACTIVE 1807 01:42:19,766 --> 01:42:23,604 INTERMEDIATE WHICH IS THE SAME 1808 01:42:23,670 --> 01:42:25,639 MADE BY THE OTHER CANNABINOID 1809 01:42:25,706 --> 01:42:27,274 FORMING ENZYMES IN THE CANNABIS 1810 01:42:27,341 --> 01:42:27,708 PLANT. 1811 01:42:27,774 --> 01:42:31,345 ALL THESE ENZYMES LONG TO THE 1812 01:42:31,411 --> 01:42:33,780 FAMILY OF ENZYMES AND YOU CAN 1813 01:42:33,847 --> 01:42:36,149 SEE IN THE FIGURE IN THE TOP 1814 01:42:36,216 --> 01:42:40,320 RIGHT ONE OF THE HALLMARKS IS AN 1815 01:42:40,387 --> 01:42:42,022 ATTACHMENT BETWEEN THE RESIDUES 1816 01:42:42,089 --> 01:42:44,525 OBSERVED IN BOTH MEMBERS OF THE 1817 01:42:44,591 --> 01:42:47,694 FAMILY AND THESE ARE CONSERVED 1818 01:42:47,761 --> 01:42:49,296 IN OUR MODELS. 1819 01:42:49,363 --> 01:42:53,901 SO IN OUR PAPER THAT WE 1820 01:42:53,967 --> 01:42:55,435 PUBLISHED WE WERE ABLE TO TAKE 1821 01:42:55,502 --> 01:42:56,403 WILD TYPE. 1822 01:42:56,470 --> 01:43:00,440 ENZYMES AND SHOW WE CAN PRODUCE 1823 01:43:00,507 --> 01:43:03,710 ACID AND ANALOGS IN VITRO USING 1824 01:43:03,777 --> 01:43:05,846 PURIFIED ENZYME AND THROUGH OVER 1825 01:43:05,913 --> 01:43:08,515 EXPRESSION AND PRODUCTION IN 1826 01:43:08,582 --> 01:43:08,782 BACTERIA. 1827 01:43:08,849 --> 01:43:10,117 AND SO THIS IS EXCITING BECAUSE 1828 01:43:10,183 --> 01:43:15,322 THE PLANT ENZYMES ARE QUITE 1829 01:43:15,389 --> 01:43:17,524 RECALCITRANT AND THIS IS THE 1830 01:43:17,591 --> 01:43:19,092 FIRST STEP TOWARDS A PROGRAM 1831 01:43:19,159 --> 01:43:21,328 WHERE WE CAN GENERATE ALL KIND 1832 01:43:21,395 --> 01:43:27,734 OF DIFFERENT MOLECULES IN 1833 01:43:27,801 --> 01:43:30,137 ANALOGS FERMENTATIVELY IN 1834 01:43:30,203 --> 01:43:34,107 BACTERIA AND THIS ALLOWS US TO 1835 01:43:34,174 --> 01:43:36,276 PRODUCE DIVERSE ANALOGS AND IN 1836 01:43:36,343 --> 01:43:41,648 CONTRAST TO THIS PLANT YOU CAN 1837 01:43:41,715 --> 01:43:43,050 DIRECTLY ACCESS FROM CBG. 1838 01:43:43,116 --> 01:43:46,320 YOU DON'T HAVE TO HAVE ACID AND 1839 01:43:46,386 --> 01:43:49,323 PLAYED WITH THE CHAIN LENGTH TO 1840 01:43:49,389 --> 01:43:55,195 ANALOGS AND THIS IS OUR EFFORT 1841 01:43:55,262 --> 01:43:58,865 TOWARD MINOR TRADITIONAL 1842 01:43:58,932 --> 01:44:00,534 CANNABINOID SCAFFOLDS AND THERE 1843 01:44:00,601 --> 01:44:02,836 ARE WITH PRESENTATIONS TODAY 1844 01:44:02,903 --> 01:44:05,005 SHOWING THERE'S STILL A LOT TO 1845 01:44:05,072 --> 01:44:06,173 LEARN ABOUT CBCs SO THEY'RE 1846 01:44:06,239 --> 01:44:08,942 EXCITED TO BE ABLE TO ACCESS THE 1847 01:44:09,009 --> 01:44:11,211 MOLECULES AND A PERK OF DOING 1848 01:44:11,278 --> 01:44:21,822 THIS ENZYMATICLY -- ENZYMA 1849 01:44:21,888 --> 01:44:24,024 ENZYMATICALLY FOR CONTROL AND WE 1850 01:44:24,091 --> 01:44:26,827 CAN LOOK AT NOT JUST THE 1851 01:44:26,893 --> 01:44:28,328 RECEPTORS BUT THE WHOLE FAMILY 1852 01:44:28,395 --> 01:44:30,964 WHERE THEY BELONG THE LIPID 1853 01:44:31,031 --> 01:44:33,700 SIGNALLING TPCRs. 1854 01:44:33,767 --> 01:44:35,702 THERE'S THREE DIFFERENT TYPES OF 1855 01:44:35,769 --> 01:44:40,073 RECEPTORS IN THE SIGNALLING 1856 01:44:40,140 --> 01:44:43,510 FAMILY AND THE LPA RECEPTORS THE 1857 01:44:43,577 --> 01:44:45,512 INDIGENOUS LIGAND HAS THE ACID 1858 01:44:45,579 --> 01:44:50,050 AND THE S1P RECEPTORS FOR WHOSE 1859 01:44:50,117 --> 01:44:55,122 NATIVE LIGAND IS A FPHOSPHATE AD 1860 01:44:55,188 --> 01:44:59,693 THE ENDOGENOUS ENDS OF THE 1861 01:44:59,760 --> 01:45:03,463 CANNABINOIDS ARE MOLECULES 1862 01:45:03,530 --> 01:45:10,971 EVERYONE SYNTHESISES AND WE'RE 1863 01:45:11,038 --> 01:45:13,106 INTERESTED HOW THEY INFLUENCE 1864 01:45:13,173 --> 01:45:14,541 SYNTHESIS OF THE 1865 01:45:14,608 --> 01:45:15,542 ENDOCANNABINOIDS KNOWN IMPACT 1866 01:45:15,609 --> 01:45:17,210 MOOD AND OTHER BIOLOGICAL 1867 01:45:17,277 --> 01:45:17,444 EFFECTS. 1868 01:45:17,511 --> 01:45:22,949 SO SAM -- SO SOME INTEREST WE 1869 01:45:23,016 --> 01:45:24,851 HAVE FROM YOU ALL AND THE FIELD 1870 01:45:24,918 --> 01:45:28,021 IS HOW DO THE MINOR CANNABINOIDS 1871 01:45:28,088 --> 01:45:31,525 PARTICULARLY CBC AND CBCA FIT IN 1872 01:45:31,591 --> 01:45:33,060 THE INFORMATION OF THE BIOLOGY 1873 01:45:33,126 --> 01:45:35,696 AND ARE THERE ACTIVITIES AT 1874 01:45:35,762 --> 01:45:40,500 OTHER LIPID CBGRs AND SOME LPA 1875 01:45:40,567 --> 01:45:42,069 RECEPTORS OR MAYBE METABOLITES 1876 01:45:42,135 --> 01:45:44,071 COULD HAVE EFFECTS THERE. 1877 01:45:44,137 --> 01:45:48,975 AND ALSO AGAIN THE INTERPLAY 1878 01:45:49,042 --> 01:45:52,813 BETWEEN THE PHYTO PHARMACOLOGY 1879 01:45:52,879 --> 01:45:55,582 AND EVEN IF SOME DON'T HAVE 1880 01:45:55,649 --> 01:45:57,517 ACTIVITY THEY COULD INFLUENCE 1881 01:45:57,584 --> 01:45:59,586 BIO SYNTHESIS AND STILL HAVE A 1882 01:45:59,653 --> 01:46:00,253 BIOLOGICAL EFFECT. 1883 01:46:00,320 --> 01:46:02,089 AND WE HEARD FROM EVERYONE ABOUT 1884 01:46:02,155 --> 01:46:05,225 INTEREST IN THE SYNERGY AND 1885 01:46:05,292 --> 01:46:06,626 WE'RE INTERESTED IN THIS ANG 1886 01:46:06,693 --> 01:46:09,629 SPECIFICALLY HOW THE EFFECT IS 1887 01:46:09,696 --> 01:46:10,997 MEDIATED AT A FUNCTIONAL LEVEL. 1888 01:46:11,064 --> 01:46:14,534 WHAT ARE THE RECEPTORS THEY'RE 1889 01:46:14,601 --> 01:46:17,204 BINDING TO TO MEDIATE THE 1890 01:46:17,270 --> 01:46:17,471 ACTIVITY. 1891 01:46:17,537 --> 01:46:19,005 THANK YOU SO MUCH FOR THE 1892 01:46:19,072 --> 01:46:19,840 OPPORTUNITY TO PRESENT TODAY. 1893 01:46:19,906 --> 01:46:22,976 VERY EXCITED TO BE HERE AND 1894 01:46:23,043 --> 01:46:24,277 THANK YOU TO OUR P.O. OR THE 1895 01:46:24,344 --> 01:46:26,279 GRANT AND THE NIH PEOPLE FOR 1896 01:46:26,346 --> 01:46:27,114 ORGANIZING AND BRAD AND GERALD 1897 01:46:27,180 --> 01:46:29,282 FOR THE OPPORTUNITY TO COME IN 1898 01:46:29,349 --> 01:46:29,850 AND REPRESENT OUR PROGRAM. 1899 01:46:29,916 --> 01:46:32,953 THANKS. 1900 01:46:33,019 --> 01:46:35,589 >> THANK YOU, DR. LOVE. 1901 01:46:35,655 --> 01:46:37,791 THANK YOU ALL NON-CLINICAL 1902 01:46:37,858 --> 01:46:38,792 P.I.s. 1903 01:46:38,859 --> 01:46:41,495 IT'S AMAZING THE AMOUNT OF DATA 1904 01:46:41,561 --> 01:46:42,662 YOU GOT DURING THIS FIVE YEARS 1905 01:46:42,729 --> 01:46:46,500 OR LESS OF THE PROGRAM AND 1906 01:46:46,566 --> 01:46:47,400 PRESENTING THEM IN SUCH A STRICT 1907 01:46:47,467 --> 01:46:47,934 TIME FRAME. 1908 01:46:48,001 --> 01:46:50,103 THIS WAS ABSOLUTELY AMAZING. 1909 01:46:50,170 --> 01:46:53,206 THANK YOU AND NOW WE'LL GOING TO 1910 01:46:53,273 --> 01:46:54,274 OUR BREAK. 1911 01:46:54,341 --> 01:46:55,475 WELL DESERVED AND WE'LL KEEP ALL 1912 01:46:55,542 --> 01:46:59,212 THE QUESTIONS FOR THE BIGGER Q&A 1913 01:46:59,279 --> 01:47:00,814 AND PANEL DISCUSSION WE'LL HAVE 1914 01:47:00,881 --> 01:47:06,186 AFTER THE CLINICAL P.I.'S 1915 01:47:06,253 --> 01:47:06,686 PRESENTATIONS. 1916 01:47:06,753 --> 01:47:08,555 PLEASE PICK UP YOUR NAME TAGS SO 1917 01:47:08,622 --> 01:47:10,190 WE'LL RECOGNIZE EACH OTHER BY 1918 01:47:10,257 --> 01:47:12,392 NAME AND BY FACE AND EVERYTHING 1919 01:47:12,459 --> 01:47:16,096 ELSE AND WE WILL SEE EACH OTHER 1920 01:47:16,163 --> 01:47:17,731 AT 11:00. 1921 01:47:17,798 --> 01:47:22,702 SO THE BREAK IS A LITTLE 1922 01:47:22,769 --> 01:47:32,012 SHORTER. 1923 01:47:32,078 --> 01:47:34,080 >> WELCOME TO THE NEXT SESSION 1924 01:47:34,147 --> 01:47:35,749 OF OUR MEETING AND THANK YOU FOR 1925 01:47:35,816 --> 01:47:40,387 BEING ON TIME. 1926 01:47:40,453 --> 01:47:42,956 BY THE WAY WE HAVE OVER 1100 1927 01:47:43,023 --> 01:47:44,825 REGISTERED FOR THE NIH VIDEOCAST 1928 01:47:44,891 --> 01:47:45,725 FOR THE MEETING. 1929 01:47:45,792 --> 01:47:47,294 WE MAY HAVE 1100 PEOPLE WATCHING 1930 01:47:47,360 --> 01:47:57,604 US RIGHT NOW. 1931 01:48:01,074 --> 01:48:11,251 I'D LIKE TO INTRODUCE DR. SEW 1932 01:48:11,318 --> 01:48:15,422 KAY CHIDEYA-CHIHOTA. 1933 01:48:15,488 --> 01:48:18,992 >> WE HAVE THE DATA BLITZ AND 1934 01:48:19,059 --> 01:48:21,394 I'LL INTRODUCE DR. YURGELUN-TODD 1935 01:48:21,461 --> 01:48:22,796 FROM THE UNIVERSITY OF UTAH. 1936 01:48:22,863 --> 01:48:27,500 HERE YOU GO. 1937 01:48:27,567 --> 01:48:28,935 SHE'S GOING TO BE PRESENTING ON 1938 01:48:29,002 --> 01:48:30,670 EXPLORING THE MECHANISMS 1939 01:48:30,737 --> 01:48:33,974 UNDERLYING THE ANALGESIC 1940 01:48:34,040 --> 01:48:40,213 PROPERTIES OF CANNABIDIOL USE 1941 01:48:40,280 --> 01:48:41,748 RESONANCE SPECTROSCOPY. 1942 01:48:41,815 --> 01:48:43,783 >> IT'S EXCITING TO HEAR THE 1943 01:48:43,850 --> 01:48:45,085 PRE-CLINICAL DATA AND NOW WE'LL 1944 01:48:45,151 --> 01:48:47,020 GO IN A DIFFERENT DIRECTION 1945 01:48:47,087 --> 01:48:48,355 WORKING WITH HUMAN SUBJECTS HAS 1946 01:48:48,421 --> 01:48:51,625 DIFFERENT KINDS OF CHALLENGES. 1947 01:48:51,691 --> 01:48:54,027 OUR OVER ALL STUDY AIMS WHICH 1948 01:48:54,094 --> 01:49:02,569 EXAMINE THE MECHANISMS WHERE CBD 1949 01:49:02,636 --> 01:49:06,673 EXTRACT BRAIN CHEMISTRY THROUGH 1950 01:49:06,740 --> 01:49:09,643 PROTON MRS AND IN RECENT YEARS 1951 01:49:09,709 --> 01:49:12,112 IT'S BEEN DEVELOPMENTS IN HOW TO 1952 01:49:12,178 --> 01:49:16,549 ACQUIRE AND INTERPRET THE MRS 1953 01:49:16,616 --> 01:49:27,093 DATA AND GLX WAS LOOKED AT 1954 01:49:27,761 --> 01:49:31,464 GLUTAMINE, GLUTAMATE AND GABA 1955 01:49:31,531 --> 01:49:33,400 AND LOOK AT THE BRAIN WITH 1956 01:49:33,466 --> 01:49:43,810 VARIOUS TECHNIQUES. 1957 01:49:46,713 --> 01:49:51,651 HERE WE'RE LOOKING AT MUSC 1958 01:49:51,718 --> 01:49:52,786 MUSCULOEMUSC 1959 01:49:52,852 --> 01:49:53,853 MUSCULOSKELETAL PAIN AND WE LOOK 1960 01:49:53,920 --> 01:49:57,223 AT THE PAIN THAT CAN BE 1961 01:49:57,290 --> 01:49:57,524 EXPERIENCED. 1962 01:49:57,590 --> 01:50:01,194 IT'S A PLACEBO-CONTROLLED STUDY 1963 01:50:01,261 --> 01:50:06,299 AND ENDURES FIVE DAYS AS A DAILY 1964 01:50:06,366 --> 01:50:08,268 ADMINISTRATION OF CBD EXTRACT OR 1965 01:50:08,335 --> 01:50:10,403 PLACEBO AND LOOKED AT PAIN 1966 01:50:10,470 --> 01:50:12,973 INTENSITY AND QUALITY OVERALL. 1967 01:50:13,039 --> 01:50:15,475 PRIOR TO THE ADMINISTRATION OF 1968 01:50:15,542 --> 01:50:16,142 CBD AND THEN PLACEBO AND 30 1969 01:50:16,209 --> 01:50:24,918 MINUTE AFTER. 1970 01:50:24,985 --> 01:50:27,654 WE HAVE AN INITIAL SCREEN WE DO 1971 01:50:27,721 --> 01:50:30,857 BEFORE ANYONE TALKS TO US AND DO 1972 01:50:30,924 --> 01:50:34,361 AN IN-PERSON SCREEN AND THERE'S 1973 01:50:34,427 --> 01:50:34,995 INDIVIDUALS BETWEEN THE PHONE 1974 01:50:35,061 --> 01:50:37,330 AND IN-PERSON SCREEN AND WHEN WE 1975 01:50:37,397 --> 01:50:39,699 INITIATED THE STUDY AT BASELINE 1976 01:50:39,766 --> 01:50:42,869 THEY ARE SCANNED AND HAD A 1977 01:50:42,936 --> 01:50:44,904 PHYSICAL EXAMINE ON BLOOD WORK 1978 01:50:44,971 --> 01:50:47,073 AND EVERYTHING TO MAKE SURE 1979 01:50:47,140 --> 01:50:52,612 THERE'S A NORMATIVE CATEGORY AND 1980 01:50:52,679 --> 01:51:01,354 IN DAY 1 THEY RECEIVE A SCAN 1981 01:51:01,421 --> 01:51:03,423 MEASUREMENTS AND REPEATED ON 1982 01:51:03,490 --> 01:51:05,358 DAY, TWO, THREE AND FOUR WITHOUT 1983 01:51:05,425 --> 01:51:07,360 A SCAN AND DAY FIVE A FINAL 1984 01:51:07,427 --> 01:51:07,660 SCAN. 1985 01:51:07,727 --> 01:51:09,362 WE HAVE FOLLOW-UP THE FOLLOWING 1986 01:51:09,429 --> 01:51:17,370 WEEK. 1987 01:51:17,437 --> 01:51:20,673 WHAT WE CHOSE TO EXAMINE WAS THE 1988 01:51:20,740 --> 01:51:23,910 SINGULAR CORTEX AND RIGHT INSULA 1989 01:51:23,977 --> 01:51:27,080 AND THIS IS A RADIO LOGIC IMAGE 1990 01:51:27,147 --> 01:51:28,948 AND WHAT WE CAN SEE AND THIS IS 1991 01:51:29,015 --> 01:51:38,558 A SAMPLE OF OUR DATA ACC 1992 01:51:38,625 --> 01:51:40,560 GLUTAMATE LEVELS DECREASED BY 1993 01:51:40,627 --> 01:51:41,995 DAY FIVE SIGNIFICANTLY. 1994 01:51:42,062 --> 01:51:44,564 WE HAVE CONSIDERABLY MORE DATA 1995 01:51:44,631 --> 01:51:46,166 BUT WE'RE IN THE PROCESS OF 1996 01:51:46,232 --> 01:51:47,233 ANALYZING IT. 1997 01:51:47,300 --> 01:51:48,802 IT'S BEEN A VERY COMPLICATED 1998 01:51:48,868 --> 01:51:52,705 STUDY TO DO AND I DO FEEL LIKE I 1999 01:51:52,772 --> 01:51:58,278 SHOULD MENTION WITH THE ADVENT 2000 01:51:58,344 --> 01:52:04,150 OF THE PANDEMIC WE WERE FROZEN 2001 01:52:04,217 --> 01:52:07,587 FOR A YEAR BECAUSE WE COULD NOT 2002 01:52:07,654 --> 01:52:09,355 DO HUMAN STUDY IN THIS 2003 01:52:09,422 --> 01:52:12,792 ENVIRONMENT BECAUSE IT WAS HARD 2004 01:52:12,859 --> 01:52:14,627 TO DISINFECT AND WE HAD THE 2005 01:52:14,694 --> 01:52:16,830 OPPORTUNITY TO REGROUP AND MOVE 2006 01:52:16,896 --> 01:52:18,031 AHEAD AND THEN OUR STAFF MOVED 2007 01:52:18,098 --> 01:52:19,966 ON TO OTHER JOBS AND HAD TO BE 2008 01:52:20,033 --> 01:52:21,367 RETRAINED. 2009 01:52:21,434 --> 01:52:25,371 THIS HAS BEEN A REAL LABOR OF 2010 01:52:25,438 --> 01:52:35,815 LOVE AND PERSEVERANCE. 2011 01:52:37,083 --> 01:52:39,452 OUR CURRENT. 2012 01:52:39,519 --> 01:52:41,821 FINDING WAS THE GLUTAMATE LEVELS 2013 01:52:41,888 --> 01:52:43,490 WERE ASSOCIATED WITH LOWER 2014 01:52:43,556 --> 01:52:44,924 SENSITIVITY AND POSITIVE 2015 01:52:44,991 --> 01:52:48,328 ASSOCIATION BETWEEN GLUTAMATE 2016 01:52:48,394 --> 01:52:54,267 AND PERATI IPHERAL MARKERS IN T 2017 01:52:54,334 --> 01:52:57,871 SCAN AND ASSOCIATED WITH REDUCE 2018 01:52:57,937 --> 01:52:58,638 INFLAMMATION IN DAY FIVE AND 2019 01:52:58,705 --> 01:53:00,006 HAVEN'T LOOKED AT THE DATA YET 2020 01:53:00,073 --> 01:53:05,378 BUT LOOKED AT THE RELATIONSHIP 2021 01:53:05,445 --> 01:53:07,313 BETWEEN BASELINE DATA AND 2022 01:53:07,380 --> 01:53:10,383 GLUTAMATE AND LOWER INTENSITY 2023 01:53:10,450 --> 01:53:12,485 PAIN AND PERIPHERAL MARKERS. 2024 01:53:12,552 --> 01:53:14,354 WE DID FIND A SIGNIFICANT 2025 01:53:14,420 --> 01:53:17,323 RELATIONSHIP RECENTLY PUBLISHED 2026 01:53:17,390 --> 01:53:21,361 AND JUST PUBLISHED THE ELEVATING 2027 01:53:21,427 --> 01:53:23,630 CIRCULATING SOLUBLE INTERLEUKIN 2028 01:53:23,696 --> 01:53:30,403 2 RECEPTOR ASSOCIATED WITH THE 2029 01:53:30,470 --> 01:53:32,071 INBALANCE IN INDIVIDUALS WITH 2030 01:53:32,138 --> 01:53:33,606 CHRONIC PAIN AND THE FIRST TIME 2031 01:53:33,673 --> 01:53:35,909 AS THE BEEN ASSOCIATED WITH 2032 01:53:35,975 --> 01:53:39,679 PERIPHERAL BLOOD MARKERS OF 2033 01:53:39,746 --> 01:53:40,046 INFLAMMATION. 2034 01:53:40,113 --> 01:53:40,914 THAT'S EXCITING TO THINK ABOUT. 2035 01:53:40,980 --> 01:53:42,715 WE'RE IN THE PROCESS OF LOOKING 2036 01:53:42,782 --> 01:53:45,518 AT A LOT OF OTHER DATA THAT 2037 01:53:45,585 --> 01:53:47,420 LOOKS AT BOTH THE SOMATIC 2038 01:53:47,487 --> 01:53:48,621 COMPONENTS OF PAIN AND THE 2039 01:53:48,688 --> 01:53:50,290 EFFECTIVE COMPONENTS OF PAIN 2040 01:53:50,356 --> 01:53:52,125 WHICH WE THINK ARE DIFFERENT IN 2041 01:53:52,192 --> 01:53:54,894 TERMS OF THE RESPONSE TO CBD. 2042 01:53:54,961 --> 01:53:56,529 AND WE THINK IT'S DIFFERENT IN 2043 01:53:56,596 --> 01:53:58,665 TERMS OF UNDERSTANDING ACUTE 2044 01:53:58,731 --> 01:54:03,536 VERSUS CHRONIC RESPONSES. 2045 01:54:03,603 --> 01:54:08,041 AND I'LL TRY TO RUSH. 2046 01:54:08,107 --> 01:54:12,111 WE'RE FINISHING OUR DATA 2047 01:54:12,178 --> 01:54:15,715 ANALYSIS AND CONTEMPLATING HOW 2048 01:54:15,782 --> 01:54:16,549 IT MAY INDICATE DIFFERENT 2049 01:54:16,616 --> 01:54:19,052 INDIVIDUALS WHO MAY BENEFIT FROM 2050 01:54:19,118 --> 01:54:21,354 THE TREATMENT OF CBD. 2051 01:54:21,421 --> 01:54:28,528 THANK YOU FOR YOUR ATTENTION. 2052 01:54:28,595 --> 01:54:32,332 THIS IS ALL THE SAME DATA I 2053 01:54:32,398 --> 01:54:32,765 SUMMARIZED. 2054 01:54:32,832 --> 01:54:39,305 >> THANK YOU, DR. YURGELUN-TODD. 2055 01:54:39,372 --> 01:54:41,374 SO OUR NEXT SPEAKER IS 2056 01:54:41,441 --> 01:54:45,678 DR. HELMAN FROM UCSF PRESENTING 2057 01:54:45,745 --> 01:54:49,082 ON NEUROIMMUNE MECHANISMS OF 2058 01:54:49,148 --> 01:54:50,650 CANNABINOIDS IN INFLAMMATORY AND 2059 01:54:50,717 --> 01:54:53,353 NEUROPATHIC PAIN. 2060 01:54:53,419 --> 01:55:01,361 >> I'M NOT DR. JUDITH HELL. 2061 01:55:01,427 --> 01:55:05,365 -- HELMAN. 2062 01:55:05,431 --> 01:55:07,967 I'M MARK SHOEMAKER AND WE USE 2063 01:55:08,034 --> 01:55:13,339 MOUSE AND HUMAN CELLS. 2064 01:55:13,406 --> 01:55:15,408 BRIEFLY OUR PROPOSAL IS 2065 01:55:15,475 --> 01:55:20,513 NEUROIMMUNE MECHANISMS AND OUR 2066 01:55:20,580 --> 01:55:22,615 HYPOTHESIS WAS AROUND AND PAIN 2067 01:55:22,682 --> 01:55:28,655 WITH MECHANISMS MEDIATED BY THE 2068 01:55:28,721 --> 01:55:31,057 CBV AND TRPV1 RECEPTOR AND THE 2069 01:55:31,124 --> 01:55:32,759 PRIMARY AIM IS TO HAND EFFECTS 2070 01:55:32,825 --> 01:55:36,396 OF MECHANISMS OF MINOR 2071 01:55:36,462 --> 01:55:39,666 CANNABINOIDS ON SENSORY NEURONS 2072 01:55:39,732 --> 01:55:45,104 AND BRAIN ENDOTHELIAL CELLS AND 2073 01:55:45,171 --> 01:55:47,140 WE STUDIED THE CANNABINOIDS 2074 01:55:47,206 --> 01:55:52,312 SHOWN HERE AND TAKE A MOMENT TO 2075 01:55:52,378 --> 01:55:53,379 SHOW THE RELATIONSHIP AND NEED 2076 01:55:53,446 --> 01:55:56,149 TO DRILL DOWN TO THE EFFECTS OF 2077 01:55:56,215 --> 01:55:57,817 THE FOUR MINOR CANNABINOIDS ON 2078 01:55:57,884 --> 01:56:00,086 CULTURES OF SENSORY NEURONS. 2079 01:56:00,153 --> 01:56:02,188 AND THIS DIFFERS FROM A LOT OF 2080 01:56:02,255 --> 01:56:06,225 THE PRIOR CHARACTERIZATIONS THAT 2081 01:56:06,292 --> 01:56:08,795 OCCURRED FOR INSTANCE TRPV1 IN 2082 01:56:08,861 --> 01:56:16,235 THE SYSTEMS OF STUDY. 2083 01:56:16,302 --> 01:56:18,304 OUR PRINCIPAL POINT IS WHETHER 2084 01:56:18,371 --> 01:56:18,805 THEY ACT IN THE PRIMARY 2085 01:56:18,871 --> 01:56:20,807 CULTURES. 2086 01:56:20,873 --> 01:56:24,510 SO OUR KEY FINDINGS HERE IS THAT 2087 01:56:24,577 --> 01:56:26,779 IN FACT THERE'S GREAT DIVERSITY 2088 01:56:26,846 --> 01:56:28,247 IN ACTION OF THESE MINOR 2089 01:56:28,314 --> 01:56:30,583 CANNABINOIDS ON THE SENSORY 2090 01:56:30,650 --> 01:56:30,817 NEURONS. 2091 01:56:30,883 --> 01:56:34,020 AND IN PARTICULAR WE FOCUSSED 2092 01:56:34,087 --> 01:56:41,060 PRINCIPALLY ON CVB AND CVN WE 2093 01:56:41,127 --> 01:56:44,597 THOUGHT CBD WAS ACTING DIRECTLY 2094 01:56:44,664 --> 01:56:46,265 ON THE NEURONS BUT THAT WAS NOT 2095 01:56:46,332 --> 01:56:47,433 THE CASE. 2096 01:56:47,500 --> 01:56:50,970 IN FACT WE FIND AND OUR EVIDENCE 2097 01:56:51,037 --> 01:56:54,474 SHOWS CBD IS ACTING INDIRECTLY 2098 01:56:54,540 --> 01:56:59,979 AND IN FACT PROBABLY TRPT PLAYS 2099 01:57:00,046 --> 01:57:03,349 A ROLE IN TRPT V1 ACTIVATION. 2100 01:57:03,416 --> 01:57:08,821 THERE'S OTHER UNKNOWN SITES OF 2101 01:57:08,888 --> 01:57:12,492 ACTION AND WE'RE INVESTIGATING 2102 01:57:12,558 --> 01:57:14,761 IN THE RECEPTOR 149. 2103 01:57:14,827 --> 01:57:17,363 THE FINAL MOMENT IS CBN IS 2104 01:57:17,430 --> 01:57:21,334 DIFFERENT FROM CBD AND EFFECTS A 2105 01:57:21,401 --> 01:57:25,805 LARGER DIAMETER OF NEURONS AND 2106 01:57:25,872 --> 01:57:29,976 NOT INVOLVED WITH CB1R AND I'LL 2107 01:57:30,042 --> 01:57:33,246 TURN IT OVER TO JUDITH TO TALK 2108 01:57:33,312 --> 01:57:36,682 ABOUT NON-SENSORY NEURONS AND 2109 01:57:36,749 --> 01:57:42,688 THE NON-CENTRAL NERVOUS SYSTEM, 2110 01:57:42,755 --> 01:57:43,089 THANK YOU. 2111 01:57:43,156 --> 01:57:46,058 >> THE MINOR CANNABINOIDS AFFECT 2112 01:57:46,125 --> 01:57:49,896 THE ACTIVATION OF NON NEURAL 2113 01:57:49,962 --> 01:57:51,731 CELLS AND HUMAN BRAIN 2114 01:57:51,798 --> 01:57:53,366 ENDOTHELIAL CELLS. 2115 01:57:53,433 --> 01:57:57,703 WE ACTIVATE THEM WITH BACTERIAL 2116 01:57:57,770 --> 01:57:59,539 IL1 BETA IN THE PRESENCE AND 2117 01:57:59,605 --> 01:58:02,275 ABSENCE OF THE MINOR 2118 01:58:02,341 --> 01:58:04,343 CANNABINOIDS AND THEY MODULATE 2119 01:58:04,410 --> 01:58:09,348 CYTOKINE PRODUCTION BY EN 2120 01:58:09,415 --> 01:58:14,454 ENDOTHELIAL CELLS AND AFFECT 2121 01:58:14,520 --> 01:58:17,824 PERMEABILITY AND ARE 2122 01:58:17,890 --> 01:58:20,660 HETEROGENOUS IN HOW THEY EFFECT 2123 01:58:20,726 --> 01:58:22,395 THANK YOU LEUKOCYTE AND THERE'S 2124 01:58:22,462 --> 01:58:25,364 DIFFERENT EFFECT AND MAGNITUDE 2125 01:58:25,431 --> 01:58:26,499 AND EFFECTS UNDER DIFFERENT 2126 01:58:26,566 --> 01:58:27,733 INFLAMMATORY CONDITIONS. 2127 01:58:27,800 --> 01:58:33,506 WE ALSO ENABLED WHAT I CONSIDER 2128 01:58:33,573 --> 01:58:37,176 AN EXCITING DISCOVERY 2129 01:58:37,243 --> 01:58:38,344 CANNABINOIDS MODULATE THE 2130 01:58:38,411 --> 01:58:39,679 INFLAMMATION VIA CENTRAL NERVOUS 2131 01:58:39,745 --> 01:58:41,247 SYSTEM MECHANISMS. 2132 01:58:41,314 --> 01:58:45,084 WE USED AN ACUTE MODEL INDUCED 2133 01:58:45,151 --> 01:58:46,519 BY LPS ADMINISTRATION. 2134 01:58:46,586 --> 01:58:48,521 IN THE EARLY STUDIES ON THE 2135 01:58:48,588 --> 01:58:52,458 PROJECT WE FOUND WE FOUND CBG, 2136 01:58:52,525 --> 01:59:01,367 CBC AND THC AND OTHERS 2137 01:59:01,434 --> 01:59:03,536 DOWNREGULATE CYTOKINES AND 2138 01:59:03,603 --> 01:59:04,971 UPREGULATE THE CYTOKINE IL IN 2139 01:59:05,037 --> 01:59:07,673 MICE. 2140 01:59:07,740 --> 01:59:11,444 FURTHERMORE WE FOUND CANNABINOID 2141 01:59:11,511 --> 01:59:17,350 RECEPTOR 1 EXPRESSING CNS 2142 01:59:17,416 --> 01:59:20,987 NEURONS AFFECT THIS AND THE TRP 2143 01:59:21,053 --> 01:59:22,855 V1 NEURONS MEDIATE THE 2144 01:59:22,922 --> 01:59:27,894 INFLAMMATORY ACTIONS IN LPS 2145 01:59:27,960 --> 01:59:28,561 TREATED MICE. 2146 01:59:28,628 --> 01:59:31,797 CBC AND CBG DO NOT MEDIATE 2147 01:59:31,864 --> 01:59:35,801 THROUGH EITHER CB OR TRP V1 IN 2148 01:59:35,868 --> 01:59:37,003 OUR MODEL. 2149 01:59:37,069 --> 01:59:41,007 AND DR. SHOEMAKER'S GROUP 2150 01:59:41,073 --> 01:59:42,775 IDENTIFIED 149 AS A NOVEL 2151 01:59:42,842 --> 01:59:45,711 CANNABINOID RESPONSIVE PROTEIN. 2152 01:59:45,778 --> 01:59:48,648 SO TO SUMMARIZE OUR STUDIES SHOW 2153 01:59:48,714 --> 01:59:50,883 MINOR CANNABINOIDS HAVE MULTIPLE 2154 01:59:50,950 --> 01:59:54,053 SITES OF ACTION INCLUDING IN THE 2155 01:59:54,120 --> 02:00:01,260 PNS AND NEURONS AND LEUKOCYTES 2156 02:00:01,327 --> 02:00:07,199 AND ENDTHELIAL CELLS AND THEY 2157 02:00:07,266 --> 02:00:08,200 MODULATE PAIN BIOLOGY AND 2158 02:00:08,267 --> 02:00:10,736 INFLAMMATION THROUGH THEIR 2159 02:00:10,803 --> 02:00:12,104 DIVERSE ACTIONS ON CELL TYPES 2160 02:00:12,171 --> 02:00:13,306 AND WANT TO UNDERSTAND THIS 2161 02:00:13,372 --> 02:00:23,816 BRAIN AND THE ROLE OF THE 2162 02:00:29,555 --> 02:00:31,824 RECEPTOR 1 IN MODULATING PAIN. 2163 02:00:31,891 --> 02:00:39,732 >> THANK YOU, HELLMAN, THANK 2164 02:00:39,799 --> 02:00:40,600 YOU. 2165 02:00:43,502 --> 02:00:45,738 SO NEXT UP IS DR. COOPER FROM 2166 02:00:45,805 --> 02:00:48,274 THE UCLA PRESENTING ON 2167 02:00:48,341 --> 02:00:53,980 SUBJECTIVE AND ANALGESIC EFFECTS 2168 02:00:54,046 --> 02:01:04,557 ON B CARYOPHYLLENE AND AS WE 2169 02:01:24,210 --> 02:01:25,778 KNOW CANNABIS IS USED FOR PAIN 2170 02:01:25,845 --> 02:01:27,713 YET THERE ARE MIXED FINDINGS AND 2171 02:01:27,780 --> 02:01:28,481 ADVERSE EFFECTS. 2172 02:01:28,547 --> 02:01:31,183 THE QUESTION WE'VE BEEN ASKING 2173 02:01:31,250 --> 02:01:34,987 ALL MORNING IS CAN CANNABIS 2174 02:01:35,054 --> 02:01:40,793 CONSTITUENTS REDUCE HARMS AND 2175 02:01:40,860 --> 02:01:42,361 IMPROVE OUTCOMES IN ALLEVIATING 2176 02:01:42,428 --> 02:01:42,561 PAIN. 2177 02:01:42,628 --> 02:01:43,596 WE HEARD OF THE EVIDENCE 2178 02:01:43,663 --> 02:01:48,567 AFFORDING THE USE OF DELTA HYDRO 2179 02:01:48,634 --> 02:01:50,002 CANNABINOID FOR PAIN AND THERE'S 2180 02:01:50,069 --> 02:01:50,936 EVIDENCE IN POPULATION-BASED 2181 02:01:51,003 --> 02:01:52,705 STUDIES AND RANDOMIZED CONTROL 2182 02:01:52,772 --> 02:01:53,706 TRIALS HAVE PROVIDED SOME 2183 02:01:53,773 --> 02:01:55,641 EVIDENCE THAT CAN BE HELPFUL FOR 2184 02:01:55,708 --> 02:01:57,510 CHRONIC PAIN PATIENTS AND WE 2185 02:01:57,576 --> 02:02:00,012 HAVE CONTROLLED LABORATORY 2186 02:02:00,079 --> 02:02:00,980 SETTINGS DEMONSTRATING IT CAN 2187 02:02:01,047 --> 02:02:03,416 REDUCE PAIN RESPONSE IN A 2188 02:02:03,482 --> 02:02:05,751 DOSE-DEPENDENT MANNER. 2189 02:02:05,818 --> 02:02:07,787 OF COURSE THESE ARE NOT WITHOUT 2190 02:02:07,853 --> 02:02:08,154 ADVERSE EFFECTS. 2191 02:02:08,220 --> 02:02:11,057 THE QUESTION IS CAN SOME OF 2192 02:02:11,123 --> 02:02:14,460 THESE CANNABIS CONSTITUENTS 2193 02:02:14,527 --> 02:02:17,797 REDUCE THE DELTA THC LEADING TO 2194 02:02:17,863 --> 02:02:19,732 THE GRANT AND THE INTEREST IN 2195 02:02:19,799 --> 02:02:23,536 LOOKING AT SOME OF THE TERPENES 2196 02:02:23,602 --> 02:02:26,839 ABUNDANTLY PRESENT OR RELATIVELY 2197 02:02:26,906 --> 02:02:31,010 PRESENT IN THE CANNABIS PLANT 2198 02:02:31,077 --> 02:02:31,744 PARTICUL 2199 02:02:31,811 --> 02:02:36,615 PARTICUL 2200 02:02:36,682 --> 02:02:37,349 PARTICUL 2201 02:02:37,416 --> 02:02:45,057 PARTICULARLY MYRCENE AND 2202 02:02:45,124 --> 02:02:48,060 CARYOPHYLLENE AND UNLIKE THC AND 2203 02:02:48,127 --> 02:02:49,662 OTHER ANALGESICS THERE ARE NO 2204 02:02:49,729 --> 02:02:55,234 REWARDING EFFECTS OF THE 2205 02:02:55,301 --> 02:03:01,040 TERPENES AND CARYOPHYLLENE HE 2206 02:03:01,107 --> 02:03:03,142 DEUCES EFFECTS OF DRUGS IN 2207 02:03:03,209 --> 02:03:05,344 ANIMAL MODELS AND HUMANS. 2208 02:03:05,411 --> 02:03:08,047 THE IDEA WAS TO EXAMINE IN A 2209 02:03:08,114 --> 02:03:10,082 SYSTEMATIC CONTROLLED MANNER 2210 02:03:10,149 --> 02:03:13,886 WHETHER MYRCENE AND BETA 2211 02:03:13,953 --> 02:03:16,188 CARYOPHYLLENE CAN REDUCE PAIN 2212 02:03:16,255 --> 02:03:18,290 RESPONSE WITH MINIMAL PSYCHO 2213 02:03:18,357 --> 02:03:21,360 ACTIVITY IN HEALTHY PARTICIPANTS 2214 02:03:21,427 --> 02:03:27,466 UP OUR CANNABINOID LABORATORY. 2215 02:03:27,533 --> 02:03:32,238 NEXT IF THEY CAN ENHANCE DELTA 9 2216 02:03:32,304 --> 02:03:35,207 INDUCED ANALGESIA AND REDUCE 2217 02:03:35,274 --> 02:03:35,541 EFFECTS. 2218 02:03:35,608 --> 02:03:37,810 LOOKING AT THE THC SPARING 2219 02:03:37,877 --> 02:03:39,678 EFFECTS OF THE TERPENES. 2220 02:03:39,745 --> 02:03:40,546 SOME WAS TALKED ABOUT EARLIER IN 2221 02:03:40,613 --> 02:03:43,182 THE ANIMAL MODELS. 2222 02:03:43,249 --> 02:03:45,918 THIS WAS A PHASED 1 DOUBLE BLIND 2223 02:03:45,985 --> 02:03:48,687 PLACEBO CONTROLLED STUDY WITH 2224 02:03:48,754 --> 02:03:50,189 HEALTHY PEOPLE THAT USED 2225 02:03:50,256 --> 02:03:50,456 CANNABIS. 2226 02:03:50,523 --> 02:03:51,624 THIS WAS CHALLENGING TO GET 2227 02:03:51,690 --> 02:03:52,691 THROUGH THE FDA. 2228 02:03:52,758 --> 02:03:53,959 TO MY KNOWLEDGE THIS WAS THE 2229 02:03:54,026 --> 02:03:55,194 FIRST TIME THIS WAS LOOKED AT IN 2230 02:03:55,261 --> 02:04:02,735 HUMANS THESE COMPOUNDS. 2231 02:04:02,802 --> 02:04:05,337 WE USED A VAPORIZED MODE OF 2232 02:04:05,404 --> 02:04:08,374 ADMINISTRATION BECAUSE THIS IS 2233 02:04:08,440 --> 02:04:11,677 HOW MOST PEOPLE ARE EXPOSED TO 2234 02:04:11,744 --> 02:04:13,279 THESE AND ECOLOGICALLY RELEVANT 2235 02:04:13,345 --> 02:04:17,049 MEANING THE DOSES WE WERE 2236 02:04:17,116 --> 02:04:19,018 EXPOSING PEOPLE TO IS WHAT 2237 02:04:19,084 --> 02:04:21,320 THEY'RE TYPICALLY EXPOSED TO 2238 02:04:21,387 --> 02:04:25,357 WHEN THEY USE CANNABIS BUT 2239 02:04:25,424 --> 02:04:29,295 GETTING THE TERPENES AND YOU SEE 2240 02:04:29,361 --> 02:04:32,198 7 OF THE 15 OUT-PATIENT 2241 02:04:32,264 --> 02:04:32,464 SESSIONS. 2242 02:04:32,531 --> 02:04:35,534 THEY WERE ABOUT EIGHT HOURS AND 2243 02:04:35,601 --> 02:04:37,369 LOOKED AT ANALGESIC EFFECTS 2244 02:04:37,436 --> 02:04:39,505 BEFORE DRUG WAS ADMINISTERED, 2245 02:04:39,572 --> 02:04:45,578 AFTER ENSURING PEOPLE HAD NOT 2246 02:04:45,644 --> 02:04:49,348 USED ANY CANNABIS THAT MORNING 2247 02:04:49,415 --> 02:04:51,917 AND HAD A LOW DOSE, 5 MILLIGRAMS 2248 02:04:51,984 --> 02:04:54,553 NOT EXPECTED TO PRODUCE 2249 02:04:54,620 --> 02:04:56,755 ANALGESIC EFFECTS ON ITS OWN 2250 02:04:56,822 --> 02:04:59,692 UNIVERSITY US A HIGHER DOSE, 15 2251 02:04:59,758 --> 02:05:02,394 MILLIGRAMS OF THC EXPECTED TO 2252 02:05:02,461 --> 02:05:04,363 PRODUCE EFFECTS AND ROBUST 2253 02:05:04,430 --> 02:05:06,465 PSYCHO ACTIVITY WE USED TWO 2254 02:05:06,532 --> 02:05:09,568 DOSES OF MYRCENE THE LOWER AND 2255 02:05:09,635 --> 02:05:13,339 HIGHER LEVEL SAME FOR BETA 2256 02:05:13,405 --> 02:05:14,807 CARYOPHYLLENE AND RANDOMIZED 2257 02:05:14,874 --> 02:05:16,242 WITHIN SUBJECT PROTOCOL. 2258 02:05:16,308 --> 02:05:21,347 I'M SHOWING YOU HERE A SIMPLI 2259 02:05:21,413 --> 02:05:26,252 SIMPLIFIED SCHEDULE AND RELEVANT 2260 02:05:26,318 --> 02:05:32,424 TERPENE AND LOOKED AT ANALGESIA 2261 02:05:32,491 --> 02:05:42,968 USING THE MODEL OF PAIN AND 2262 02:05:45,738 --> 02:05:47,039 ASKED DO YOU LIKE THE DRUG, 2263 02:05:47,106 --> 02:05:48,540 WOULD YOU TAKE IT AGAIN AND HOW 2264 02:05:48,607 --> 02:05:49,341 STRONG IS THE DRUG. 2265 02:05:49,408 --> 02:05:54,980 WE LOOKED AT THC AND MYRCENE AND 2266 02:05:55,047 --> 02:05:55,781 BETA CARYOPHYLLENE ITSELF TO 2267 02:05:55,848 --> 02:05:58,784 COMPARE THEM TO THC BY 2268 02:05:58,851 --> 02:06:01,820 THEMSELVES AND THEN LOOKED AT 2269 02:06:01,887 --> 02:06:03,789 THE DOSE COMBINATIONS. 2270 02:06:03,856 --> 02:06:08,527 IT'S A LENGTHY STUDY AND WE'RE 2271 02:06:08,594 --> 02:06:12,031 COLLECTING BLOOD, PLASMA SAMPLES 2272 02:06:12,097 --> 02:06:15,701 TO LOOK AT THE PHARMACO KINETIC 2273 02:06:15,768 --> 02:06:19,838 ACTIONS AND ASSOCIATE HOME TO 2274 02:06:19,905 --> 02:06:20,906 WITH BEHAVIORAL OUTCOMES. 2275 02:06:20,973 --> 02:06:22,174 WE'VE SEEN A LOT OF PARTICIPANTS 2276 02:06:22,241 --> 02:06:25,878 AND HAD MANY ENROLLED. 2277 02:06:25,945 --> 02:06:27,012 WE'VE ALSO HAD A LOT OF 2278 02:06:27,079 --> 02:06:27,746 WITHDRAWALS. 2279 02:06:27,813 --> 02:06:28,847 THIS IS A CHALLENGING STUDY IN 2280 02:06:28,914 --> 02:06:31,984 PART DUE TO THE LENGTH. 2281 02:06:32,051 --> 02:06:34,086 WE HAVE TO MAKE SURE THERE'S 2282 02:06:34,153 --> 02:06:38,757 AMPLE TIME FOR WASH OUT AND HAD 2283 02:06:38,824 --> 02:06:40,159 EIGHT PEOPLE COMPLETE ONCE 2284 02:06:40,225 --> 02:06:42,795 ENROLLED AND HAD A LOT OF 2285 02:06:42,861 --> 02:06:43,095 SESSIONS. 2286 02:06:43,162 --> 02:06:44,797 APOLOGIZE FOR FORMATTING ISSUES 2287 02:06:44,863 --> 02:06:47,333 AND HAD 171 SESSIONS COMPLETED 2288 02:06:47,399 --> 02:06:50,402 AND NOT MANY ADVERSE EVENTS. 2289 02:06:50,469 --> 02:06:53,339 TO APPEASE THE FDA WE LOOK AT 2290 02:06:53,405 --> 02:06:58,143 ADVERSE EVENTS STRINGENTLY AND 2291 02:06:58,210 --> 02:07:01,013 HAD FEW MINOR ADVERSE EVENTS 2292 02:07:01,080 --> 02:07:01,880 RELATED TO TERPENE 2293 02:07:01,947 --> 02:07:02,548 ADMINISTRATION GIVEN ALL THE 2294 02:07:02,614 --> 02:07:11,390 SESSIONS WE'VE ADMINISTERED. 2295 02:07:11,457 --> 02:07:13,525 STEP 1 IS THE MAXIMUM PAIN 2296 02:07:13,592 --> 02:07:16,528 RELIEF AND MINIMAL INTOXICATION 2297 02:07:16,595 --> 02:07:21,367 AND RUN PHARMACO KINETIC 2298 02:07:21,433 --> 02:07:22,868 ANALYSIS AND ASSESS THE DOSE 2299 02:07:22,935 --> 02:07:24,069 COMBINATION TO LOOK AT THE 2300 02:07:24,136 --> 02:07:26,171 OPIOID SPARING EFFECTS TO 2301 02:07:26,238 --> 02:07:28,107 PERHAPS REDUCE OPIOID DOSES TO 2302 02:07:28,173 --> 02:07:30,442 ACHIEVE PAIN RELIEF AND WE HEARD 2303 02:07:30,509 --> 02:07:32,711 OF ABOUT WORK IN THIS AREA THIS 2304 02:07:32,778 --> 02:07:33,278 MORNING. 2305 02:07:33,345 --> 02:07:34,680 AND LASTLY THOUGH NOT PRIOR TO 2306 02:07:34,747 --> 02:07:38,851 THE GRANT IS TO CONSIDER 2307 02:07:38,917 --> 02:07:41,086 ALTERNATIVE MODES OF 2308 02:07:41,153 --> 02:07:41,453 ADMINISTRATION. 2309 02:07:41,520 --> 02:07:41,854 VAP 2310 02:07:41,920 --> 02:07:44,857 VAPORIZING IS NOT THE BEST 2311 02:07:44,923 --> 02:07:47,292 EFFECT AND LOOKING AT ORAL 2312 02:07:47,359 --> 02:07:48,761 ADMINISTRATION NEXT. 2313 02:07:48,827 --> 02:07:50,129 WE'VE HAD SERIOUS CHALLENGES 2314 02:07:50,195 --> 02:07:51,563 WE'VE HAD TO COME UP AGAINST BUT 2315 02:07:51,630 --> 02:07:52,464 COOL TO BE ABLE TO DO THIS WORK. 2316 02:07:52,531 --> 02:08:01,073 THANK YOU. 2317 02:08:01,140 --> 02:08:02,141 >> THANK YOU. 2318 02:08:02,207 --> 02:08:03,008 REALLY INTERESTING. 2319 02:08:03,075 --> 02:08:13,352 OKAY, DR. HARTE. 2320 02:08:23,962 --> 02:08:25,998 >> I'M LOOKING AT PAIN 2321 02:08:26,065 --> 02:08:32,137 MECHANISMS IN OSTEOARTHRITIS. 2322 02:08:32,204 --> 02:08:34,440 >> THANK YOU. 2323 02:08:34,506 --> 02:08:36,141 UNFORTUNATELY DR. HARTE COULDN'T 2324 02:08:36,208 --> 02:08:40,913 MAKE IT SO I'M ON THE STUDY AND 2325 02:08:40,979 --> 02:08:42,114 LOOKING AT CANNABINOID 2326 02:08:42,181 --> 02:08:44,450 INTERACTIONS AND CENTRAL AND 2327 02:08:44,516 --> 02:08:51,790 PERIPHERAL PAIN MECHANISMS IN 2328 02:08:51,857 --> 02:08:53,759 OSTEOARTHRITIS PAIN AND SEE IF 2329 02:08:53,826 --> 02:08:55,594 THEY RESPOND DIFFERENTLY TO CBD, 2330 02:08:55,661 --> 02:09:00,732 THC OR THEIR COMBINATION. 2331 02:09:00,799 --> 02:09:05,337 I'LL TELL YOU ABOUT OR STUDY 2332 02:09:05,404 --> 02:09:06,472 DESIGN AND SUMMARIZE CHALLENGES 2333 02:09:06,538 --> 02:09:09,174 IN OUR TRIAL. 2334 02:09:09,241 --> 02:09:12,244 IT'S A RANDOMIZED PLACEBO 2335 02:09:12,311 --> 02:09:13,946 CONTROLLED DOUBLE-BLIND STUDY 2336 02:09:14,012 --> 02:09:18,117 AND HAVE KNEE OSTEOARTHRITIS 2337 02:09:18,183 --> 02:09:20,919 PATIENTS AND RANDOMIZED TO ONE 2338 02:09:20,986 --> 02:09:25,357 OF FOUR GROUPS EITHER CBC ALONE, 2339 02:09:25,424 --> 02:09:27,759 THC ALONE OR COMBINATION OF BOTH 2340 02:09:27,826 --> 02:09:29,828 OUR PLACEBO. 2341 02:09:29,895 --> 02:09:31,830 THOSE ARE OUR FOUR GROUPS. 2342 02:09:31,897 --> 02:09:39,771 OUR PRIMARY OUTCOME IS TO LOOK 2343 02:09:39,838 --> 02:09:44,309 AT THE CONNECTIVITY IN THE BRAIN 2344 02:09:44,376 --> 02:09:49,882 AND THE OTHER CO-PRIMARY OUTCOME 2345 02:09:49,948 --> 02:09:56,555 IS TO LOOK AT CBD LOOKING AT 2346 02:09:56,622 --> 02:09:58,490 REDUCING IL6 CONCENTRATION AND 2347 02:09:58,557 --> 02:10:04,997 THINK THC WILL BE ACTING MORE 2348 02:10:05,063 --> 02:10:10,169 CENTRALLY IN THE BRAIN WHERE CBD 2349 02:10:10,235 --> 02:10:11,637 MAY ACT ON IL6. 2350 02:10:11,703 --> 02:10:13,338 THAT'S OUR HYPOTHESIS AND WHAT 2351 02:10:13,405 --> 02:10:23,782 WE'RE HOPING TO STUDY. 2352 02:10:28,620 --> 02:10:31,590 WE LOOKED AT THE STRUCTURE AND 2353 02:10:31,657 --> 02:10:33,926 FOUND THAT CONNECTIVITY PATTERN 2354 02:10:33,992 --> 02:10:38,897 WAS MORE AMPLIFIED IN 2355 02:10:38,964 --> 02:10:41,166 INDIVIDUALS WITH MORE 2356 02:10:41,233 --> 02:10:43,802 CENTRALIZED PAIN OR MORE 2357 02:10:43,869 --> 02:10:46,471 FIBROMYALGIA LIKE SYMPTOMS ANDIS 2358 02:10:46,538 --> 02:10:51,710 THIS THEY MAY BE MORE PREVALENT 2359 02:10:51,777 --> 02:10:53,412 IN SOME KNEE OSTEOARTHRITIS 2360 02:10:53,478 --> 02:10:55,013 PATIENTS AND MAY BE MORE LIKELY 2361 02:10:55,080 --> 02:10:58,517 TO RESPOND TO THC COMPOUNDS AND 2362 02:10:58,584 --> 02:11:00,452 PATIENTS THAT DON'T HAVE THOSE 2363 02:11:00,519 --> 02:11:02,955 SYSTEMS AND LOW CENTRALIZATION 2364 02:11:03,021 --> 02:11:04,990 MIGHT RESPOND BETTER TO CBD AND 2365 02:11:05,057 --> 02:11:07,259 HAVE MORE OF AN ANALGESIC EFFECT 2366 02:11:07,326 --> 02:11:11,463 ON INFLAMMATION OF THE KNEE. 2367 02:11:11,530 --> 02:11:14,933 SO SO FAR WE'VE BASICALLY 2368 02:11:15,000 --> 02:11:17,869 RECRUITED OVER 54 PATIENTS IN 2369 02:11:17,936 --> 02:11:19,538 THE STUDY AND WE'RE GOING TO 2370 02:11:19,605 --> 02:11:20,839 CONTINUE RECRUITING. 2371 02:11:20,906 --> 02:11:23,675 WE HAD SIGNIFICANT CHALLENGES AS 2372 02:11:23,742 --> 02:11:25,711 MANY HAVE AS WELL SO WE WERE 2373 02:11:25,777 --> 02:11:27,579 LAGGING INITIALLY BECAUSE OF 2374 02:11:27,646 --> 02:11:29,881 COVID AND STARTED LATE AND THEN 2375 02:11:29,948 --> 02:11:35,954 IN ADDITION IN MICHIGAN WE HAVE 2376 02:11:36,021 --> 02:11:39,591 RECREATIONAL USE OF CANNABIS 2377 02:11:39,658 --> 02:11:41,159 LEGALLY USED RECREATIONALLY AND 2378 02:11:41,226 --> 02:11:42,628 PEOPLE ARE LESS LIKELY TO ENROLL 2379 02:11:42,694 --> 02:11:45,163 IN A STUDY WHEN THEY CAN GO TO 2380 02:11:45,230 --> 02:11:55,707 THE DISPENSARY AND GET SOME. 2381 02:11:56,675 --> 02:12:02,714 AND THEN ALSO MANY TIMES THEY 2382 02:12:02,781 --> 02:12:04,416 COME TO STUDY THEY HAVE A 2383 02:12:04,483 --> 02:12:09,354 SIGNIFICANT LEVEL OF PAIN BEFORE 2384 02:12:09,421 --> 02:12:13,058 THEY ENTER IN THE TRIAL AND SO 2385 02:12:13,125 --> 02:12:18,130 WE WERE TRYING TO WASH THAT OUT 2386 02:12:18,196 --> 02:12:19,464 BEFORE THE ACTUAL ADMINISTRATION 2387 02:12:19,531 --> 02:12:22,401 AND HAVE A TWO-WEEK RUN-IN 2388 02:12:22,467 --> 02:12:22,634 PERIOD. 2389 02:12:22,701 --> 02:12:26,972 IF PATIENTS HAVE LESS THAN THAN 2390 02:12:27,039 --> 02:12:28,740 AN ANALOG SCALE FOR THE PAIN 2391 02:12:28,807 --> 02:12:30,075 THEY WON'T BE ALLOWED TO 2392 02:12:30,142 --> 02:12:34,813 CONTINUE IN THE STUDY. 2393 02:12:34,880 --> 02:12:38,850 WE'VE HAD A LOT OF PARTICIPANTS 2394 02:12:38,917 --> 02:12:40,352 HAD A STRONG PLACEBO RESPONSE 2395 02:12:40,419 --> 02:12:41,353 MAKING THEM UNABLE TO CONTINUE 2396 02:12:41,420 --> 02:12:42,087 IN THE STUDY. 2397 02:12:42,154 --> 02:12:43,922 ON THE PLUS SIDE WE HAVE PEOPLE 2398 02:12:43,989 --> 02:12:45,357 WHO DON'T HAVE A PLACEBO 2399 02:12:45,424 --> 02:12:47,659 RESPONSE BUT ON THE NEGATIVE 2400 02:12:47,726 --> 02:12:49,328 SIDE IT'S MAKING MORE DIFFICULT 2401 02:12:49,394 --> 02:12:52,264 TO RECRUIT BECAUSE WE'VE GOT THE 2402 02:12:52,331 --> 02:12:56,868 REGRESSION TO THE MEAN AND 2403 02:12:56,935 --> 02:13:03,408 FINALLY THERE'S BEEN SHORTAGE 2404 02:13:03,475 --> 02:13:06,712 AND SO THAT HAS ALSO CAUSED US 2405 02:13:06,778 --> 02:13:07,646 SOME SLOW UP AS WELL BUT 2406 02:13:07,713 --> 02:13:09,348 HOPEFULLY BY THE TIME WE HAVE 2407 02:13:09,414 --> 02:13:11,283 OUR NEXT MEETING WE'LL BE ABLE 2408 02:13:11,350 --> 02:13:12,751 TO PRESENT THE USE IN DATA AND 2409 02:13:12,818 --> 02:13:14,286 SHOW YOU SOME OF OUR FINDINGS WE 2410 02:13:14,353 --> 02:13:14,486 HAVE. 2411 02:13:14,553 --> 02:13:22,961 SO THANK YOU VERY MUCH. 2412 02:13:23,028 --> 02:13:25,964 >> THANK YOU YOU, DR. HARRIS. 2413 02:13:26,031 --> 02:13:30,902 DR. BIDWELL FROM UNIVERSITY OF 2414 02:13:30,969 --> 02:13:33,338 COLORADO. 2415 02:13:33,405 --> 02:13:33,772 THANK YOU. 2416 02:13:33,839 --> 02:13:36,975 AND SHE'S GOING TO TO BE 2417 02:13:37,042 --> 02:13:38,377 PRESENTING ON SELF-SELECTED 2418 02:13:38,443 --> 02:13:40,445 CANNABIS USE AMONG INDIVIDUALS 2419 02:13:40,512 --> 02:13:41,246 WITH CHRONIC LOW BACK PAIN. 2420 02:13:41,313 --> 02:13:41,513 >> HELLO. 2421 02:13:41,580 --> 02:13:45,350 THANK YOU. 2422 02:13:45,417 --> 02:13:49,354 THANK YOU FOR THE OPPORTUNITY TO 2423 02:13:49,421 --> 02:13:50,689 SPEAK WITH YOU AND I'LL PRESENT 2424 02:13:50,756 --> 02:13:56,395 DATA ON OUR HUMAN STUDY OF 2425 02:13:56,461 --> 02:13:57,229 SELF-SELECTED EDIBLE CANNABIS 2426 02:13:57,295 --> 02:13:58,697 USE AMONG INDIVIDUALS WITH 2427 02:13:58,764 --> 02:14:00,232 CHRONIC LOW BACK PAIN AND THIS 2428 02:14:00,298 --> 02:14:02,401 WAS FUNDED SIX YEARS AGO AND 2429 02:14:02,467 --> 02:14:03,235 RECENTLY WRAPPED UP THE DATA 2430 02:14:03,301 --> 02:14:04,069 COLLECTION. 2431 02:14:04,136 --> 02:14:06,004 I'M EXCITED TO SHARE PRELIMINARY 2432 02:14:06,071 --> 02:14:09,341 FINDINGS WITH YOU ALL FROM THIS 2433 02:14:09,408 --> 02:14:09,541 WORK. 2434 02:14:09,608 --> 02:14:11,610 THE GOAL WAS TO USE PROSPECTIVE 2435 02:14:11,676 --> 02:14:15,680 AND NATURALISTIC DESIGN TO 2436 02:14:15,747 --> 02:14:17,048 UNDERSTAND THE THERAPEUTIC 2437 02:14:17,115 --> 02:14:20,852 EFFECTS AND PHARMACOLOGY AS 2438 02:14:20,919 --> 02:14:22,687 PHARMACOLOGY IN THE WILD FOR 2439 02:14:22,754 --> 02:14:23,722 CANNABIS USE FOR CHRONIC PAIN. 2440 02:14:23,789 --> 02:14:29,795 WE INVESTIGATED A WIDELY USED 2441 02:14:29,861 --> 02:14:31,730 EDIBLE IN OUR COLORADO STATE 2442 02:14:31,797 --> 02:14:33,165 LEGAL MARKET. 2443 02:14:33,231 --> 02:14:33,865 INTERESTED IN ANALGESIC AND 2444 02:14:33,932 --> 02:14:36,334 THERAPEUTIC EFFECTS ON PAIN AND 2445 02:14:36,401 --> 02:14:38,236 POTENTIAL NEGATIVE ADVERSE SIDE 2446 02:14:38,303 --> 02:14:41,339 EFFECTS OF CANNABIS USE IN THE 2447 02:14:41,406 --> 02:14:42,374 POPULATION INITIATED CANNABIS 2448 02:14:42,441 --> 02:14:43,175 USE FOR PAIN AND WE'RE 2449 02:14:43,241 --> 02:14:45,143 INTERESTED IN THE IDEA THAT 2450 02:14:45,210 --> 02:14:47,612 EFFECTS MAY DIFFER DEPENDING ON 2451 02:14:47,679 --> 02:14:48,513 DOSE AND RATIO TO CBD IN THE 2452 02:14:48,580 --> 02:14:51,883 EDIBLE. 2453 02:14:51,950 --> 02:14:53,018 A LITTLE BIT ABOUT OUR DESIGN. 2454 02:14:53,084 --> 02:14:55,086 THIS AGAIN IS A PROSPECTIVE 2455 02:14:55,153 --> 02:14:55,387 STUDY. 2456 02:14:55,454 --> 02:15:00,125 WE BROUGHT IN INDIVIDUALS WHO 2457 02:15:00,192 --> 02:15:01,159 HAD CHRONIC PAIN LOW BACK PAIN 2458 02:15:01,226 --> 02:15:03,361 WITH SIX MONTHS OF SELF-REPORTED 2459 02:15:03,428 --> 02:15:04,996 BACK PAIN AND WERE NOT YET USING 2460 02:15:05,063 --> 02:15:06,665 CANNABIS TO USE THAT PAIN. 2461 02:15:06,731 --> 02:15:07,899 THEY'RE INTERESTED IN STARTING 2462 02:15:07,966 --> 02:15:10,335 AND WE'RE CATCHING THEM AT THE 2463 02:15:10,402 --> 02:15:14,973 BEGINNING AND PROVIDING FOR A 2464 02:15:15,040 --> 02:15:16,842 BASELINE AND THIS IS FIVE YEARS 2465 02:15:16,908 --> 02:15:20,879 OF DATA COLLECTION. 2466 02:15:20,946 --> 02:15:22,481 IT TOOK A LOT OF TIME AND AT 2467 02:15:22,547 --> 02:15:25,383 BASELINE THEY WENT TO A LOCAL 2468 02:15:25,450 --> 02:15:26,251 DISPENSARY AND PURCHASED THEIR 2469 02:15:26,318 --> 02:15:28,320 PRODUCT AND WERE ABLE TO SELECT 2470 02:15:28,386 --> 02:15:30,355 FROM A RANGE OF CANNABIS 2471 02:15:30,422 --> 02:15:31,089 PRODUCTS AVAILABLE IN THE LEGAL 2472 02:15:31,156 --> 02:15:31,823 MARKET AND A LITTLE BIT OF WHAT 2473 02:15:31,890 --> 02:15:33,859 THAT LOOKS LIKE. 2474 02:15:33,925 --> 02:15:36,495 HALF OF THE STUDY POPULATION 2475 02:15:36,561 --> 02:15:37,863 SELECTED 47% SELECTED A PRODUCT 2476 02:15:37,929 --> 02:15:39,764 THAT WAS BALANCED OR SIMILAR 2477 02:15:39,831 --> 02:15:43,668 LEVELS OF THC TO CBD. 2478 02:15:43,735 --> 02:15:46,271 38% SELECTED A CBD DOMINANT 2479 02:15:46,338 --> 02:15:48,240 PRODUCT WITH LITTLE OR NO THC 2480 02:15:48,306 --> 02:15:53,278 AND 15% SELECTED A THC DOMINANT 2481 02:15:53,345 --> 02:15:54,579 WITH NUL OR ZERO CBD. 2482 02:15:54,646 --> 02:15:56,348 INTERESTING THE GROUPS ARE 2483 02:15:56,414 --> 02:15:59,017 SIMILAR IN PAIN LEVELS AND DID 2484 02:15:59,084 --> 02:15:59,751 NOT DIFFER DEMOGRAPHICALLY THEY 2485 02:15:59,818 --> 02:16:02,420 LOOKED SIMILAR. 2486 02:16:02,487 --> 02:16:03,555 THE MAIN DIFFERENCE WAS THOSE 2487 02:16:03,622 --> 02:16:06,358 INTERESTED IN A THC PRODUCT HAD 2488 02:16:06,424 --> 02:16:08,927 A HIGHER RATIO OF MALES TO 2489 02:16:08,994 --> 02:16:17,068 FEMALES THOUGH THE SAMPLE IS 2490 02:16:17,135 --> 02:16:17,602 MAINLY FEMALE. 2491 02:16:17,669 --> 02:16:19,971 THEY HAD TWO WEEKS TO USE THE 2492 02:16:20,038 --> 02:16:22,874 PRODUCT OR LITTLE AS THEY WANTED 2493 02:16:22,941 --> 02:16:24,809 AND TRACKED THAT IN DETAIL AND 2494 02:16:24,876 --> 02:16:28,179 AT THE TWO-WEEK TIME POINT WE 2495 02:16:28,246 --> 02:16:30,549 MET THEM AT THEIR HOME IN OUR 2496 02:16:30,615 --> 02:16:30,882 MOBILE LAB. 2497 02:16:30,949 --> 02:16:37,389 IT ALLOWED US TO STUDY THE ACUTE 2498 02:16:37,455 --> 02:16:42,694 EFFECTS AND USED THE MOBILE LAB 2499 02:16:42,761 --> 02:16:48,767 TO GET ASSESSMENTS PRIOR AND 2500 02:16:48,833 --> 02:16:51,836 LOOKED AT ONE HOUR AFTER NEWS 2501 02:16:51,903 --> 02:16:55,473 AND TWO HOURS AFTER INGESTION. 2502 02:16:55,540 --> 02:16:56,575 SOME PRELIMINARY DATA IS WHAT 2503 02:16:56,641 --> 02:16:58,176 THIS LOOKS LIKE IN THE MOBILE 2504 02:16:58,243 --> 02:16:58,343 LAB. 2505 02:16:58,410 --> 02:17:01,346 WHAT DID PEOPLE USE AND WHAT DID 2506 02:17:01,413 --> 02:17:02,814 THEIR CANNABINOID EXPOSURE LOOK 2507 02:17:02,881 --> 02:17:03,949 LIKE AFTER USE OF THAT LEGAL 2508 02:17:04,015 --> 02:17:04,616 MARKET PRODUCT? 2509 02:17:04,683 --> 02:17:06,885 YOU CAN SEE ACROSS THE THREE 2510 02:17:06,952 --> 02:17:10,255 PRODUCT GROUPS THE INGESTIONS OF 2511 02:17:10,322 --> 02:17:11,723 SPECIFIC CANNABINOIDS AS WELL AS 2512 02:17:11,790 --> 02:17:14,225 THE EXPOSURE LINE UP NICELY WITH 2513 02:17:14,292 --> 02:17:16,861 WHAT YOU'D EXPECT. 2514 02:17:16,928 --> 02:17:18,597 ALSO INTERESTING TO HIGHLIGHT 2515 02:17:18,663 --> 02:17:21,066 WHAT PEOPLE PREFER TO TAKE AND 2516 02:17:21,132 --> 02:17:25,270 THE THC DOSING LINING UP UNDER 2517 02:17:25,337 --> 02:17:29,341 10 MILLIGRAMS PER USE ACROSS THE 2518 02:17:29,407 --> 02:17:33,345 THC PRODUCT GROUPS AND CBD 2519 02:17:33,411 --> 02:17:34,145 LOOKING A LITTLE BIT HIGHER IN 2520 02:17:34,212 --> 02:17:44,723 TERMS OF THEIR INGESTED DOSE. 2521 02:17:45,490 --> 02:17:55,934 SO THIS IS HOW THEY REPORTED 2522 02:18:00,972 --> 02:18:02,173 THEIR SELF-REPORT ONE AND 2523 02:18:02,240 --> 02:18:04,743 TWO-HOUR POST USE AND SEE A 2524 02:18:04,809 --> 02:18:07,012 TRENDING EFFECT AND THC 2525 02:18:07,078 --> 02:18:08,780 CONNECTED PRODUCTS SHOWING A 2526 02:18:08,847 --> 02:18:10,582 STRONGER ASSOCIATION WITH PAIN 2527 02:18:10,649 --> 02:18:13,084 RELIEF OVER TIME AND FOLLOWED UP 2528 02:18:13,151 --> 02:18:17,555 LOOKING AT INDIVIDUAL DOSING 2529 02:18:17,622 --> 02:18:25,563 SPECIFICALLY WE SEE A STRONGER 2530 02:18:25,630 --> 02:18:27,699 AFFECTS AND WE SEE ASSOCIATIONS 2531 02:18:27,766 --> 02:18:32,570 WITH THC SHOWING SLIGHT INCREASE 2532 02:18:32,637 --> 02:18:33,838 IN NEGATIVE MOOD ACROSS THE 2533 02:18:33,905 --> 02:18:34,906 MOBILE LAB APPOINTMENT AND 2534 02:18:34,973 --> 02:18:36,307 SIMILARLY LOOKING AT DRUG 2535 02:18:36,374 --> 02:18:39,844 EFFECTS WE SEE INTOXICATION AND 2536 02:18:39,911 --> 02:18:41,846 CANNABIS DRUG EFFECTS AND THC 2537 02:18:41,913 --> 02:18:44,516 AND NEITHER SEEM TO BE MITIGATED 2538 02:18:44,582 --> 02:18:46,551 BY CBD BEING IN THE PRODUCT OR 2539 02:18:46,618 --> 02:18:49,154 NOT IS A THC STORY. 2540 02:18:49,220 --> 02:18:50,889 WHEN WE THINK ABOUT NEXT STEPS 2541 02:18:50,955 --> 02:18:53,324 THIS IS A HUGE DATA SET AND RICH 2542 02:18:53,391 --> 02:18:56,094 BEHAVIORAL DATA AND WE HAVE 2543 02:18:56,161 --> 02:19:00,165 DAILY DATA AND CIRCULATING 2544 02:19:00,231 --> 02:19:02,500 CYTOKINES AND LPS STIMULATING 2545 02:19:02,567 --> 02:19:04,269 CYTOKINES AND HAVE WORK TO DO IN 2546 02:19:04,335 --> 02:19:06,504 ANALYZING THE DATA AND PRIMARILY 2547 02:19:06,571 --> 02:19:09,340 FOR HOW TO IT SEEMS TO BE A THC 2548 02:19:09,407 --> 02:19:11,843 STORY AND THIS IDEA THAT CBD ON 2549 02:19:11,910 --> 02:19:14,512 BOARD AT THE DOSES PEOPLE ARE 2550 02:19:14,579 --> 02:19:16,481 USING IN LEGAL MARKET PRODUCTS 2551 02:19:16,548 --> 02:19:23,388 IS NOT ASSIGNED THESE EFFECTS. 2552 02:19:23,455 --> 02:19:25,390 THANKS SO MUCH MY COLLABORATORS 2553 02:19:25,457 --> 02:19:27,025 ON THE WORK AND WE SPENT A LOT 2554 02:19:27,092 --> 02:19:28,126 OF TIME WORKING AND THINKING 2555 02:19:28,193 --> 02:19:28,727 ABOUT THE STUDIES TOGETHER. 2556 02:19:28,793 --> 02:19:33,231 THANK YOU. 2557 02:19:33,298 --> 02:19:38,937 >> THANK YOU. 2558 02:19:39,003 --> 02:19:44,109 >> LAST BUT NOT LEAST WE HAVE 2559 02:19:44,175 --> 02:19:45,810 DR. RADHAKRISHNAN FROM YALE 2560 02:19:45,877 --> 02:19:49,848 SCHOOL OF MEDICINE PRESENTING ON 2561 02:19:49,914 --> 02:19:55,120 THE EFFECT OF CANNABIDIOL ON 2562 02:19:55,186 --> 02:19:58,990 MICROGLIAL AND PAIN 2563 02:19:59,057 --> 02:19:59,324 SENSITIZATION. 2564 02:19:59,390 --> 02:20:02,427 >> THANK YOU TO NCCIH FOR 2565 02:20:02,494 --> 02:20:03,762 ORGANIZING THIS AND IT'S GREAT 2566 02:20:03,828 --> 02:20:05,029 TO SEE EVERYBODY. 2567 02:20:05,096 --> 02:20:06,564 WE'RE TALKING ABOUT THE STUDY WE 2568 02:20:06,631 --> 02:20:11,069 WERE FUNDED TO DO. 2569 02:20:11,136 --> 02:20:14,005 MY CO-INVESTIGATORS 2570 02:20:14,072 --> 02:20:18,209 UNFORTUNATELY COULDN'T BE HERE. 2571 02:20:18,276 --> 02:20:24,449 WE STUDY THE CANNABIDIOL AND WE 2572 02:20:24,516 --> 02:20:27,252 KNOW ACTIVATION IS A TARGET FOR 2573 02:20:27,318 --> 02:20:30,555 CHRONIC PAIN AND LOOKING AT 2574 02:20:30,622 --> 02:20:33,258 NEUROPATHIC PAIN AND CHRONIC 2575 02:20:33,324 --> 02:20:37,428 BACK PAIN AND FIBROMYALGIA AND 2576 02:20:37,495 --> 02:20:41,199 LOOK AT PAIN SENSITIZATION A 2577 02:20:41,266 --> 02:20:42,634 MECHANISM IN CHRONIC PAIN AND 2578 02:20:42,700 --> 02:20:45,370 CONTRIBUTES TO THE TRANSITION 2579 02:20:45,436 --> 02:20:46,805 FROM ACUTE TO CHRONIC PAIN. 2580 02:20:46,871 --> 02:20:56,147 NOW, IN PRECLINICAL STUDIES TRP 2581 02:20:56,214 --> 02:20:58,750 V1 ANTAGONIST AFFECT PAIN 2582 02:20:58,817 --> 02:21:00,051 SENSITIZATION AND IN STUDIES 2583 02:21:00,118 --> 02:21:03,988 WITH CBD IT'S BEEN SHOWN TO 2584 02:21:04,055 --> 02:21:10,562 PREVENT BRAIN AND SPINAL MIC 2585 02:21:10,628 --> 02:21:13,064 MICROGLIAL ACTIVATION AND LOOKED 2586 02:21:13,131 --> 02:21:17,302 AT THE BIOLOGICAL MECHANISM AND 2587 02:21:17,368 --> 02:21:20,238 CENTRAL PAIN MECHANISM 2588 02:21:20,305 --> 02:21:22,207 UNDERLYING CHRONIC PAIN. 2589 02:21:22,273 --> 02:21:25,577 ONE OF THE CHALLENGES WE HEARD 2590 02:21:25,643 --> 02:21:27,412 ABOUT THE PRECLINICAL STUDIES 2591 02:21:27,478 --> 02:21:29,347 AND SEE EFFECTS OF CBD ON PAIN 2592 02:21:29,414 --> 02:21:32,083 AND RANDOMIZED CONTROL TRIALS ON 2593 02:21:32,150 --> 02:21:32,951 HUMANS HAVE NOT BEEN THAT 2594 02:21:33,017 --> 02:21:35,053 POSITIVE AND HAS BEEN A 2595 02:21:35,119 --> 02:21:36,054 CHALLENGE WE HAVE TO BRIDGE SO 2596 02:21:36,120 --> 02:21:45,063 THE STUDY IS PRIMARILY IN 2597 02:21:45,129 --> 02:21:45,296 HUMANS. 2598 02:21:45,363 --> 02:21:48,466 AND WE LOOK AT ACTIVATION AND AS 2599 02:21:48,533 --> 02:21:56,307 YOU CAN SEE IN FIGURE 1 THE 2600 02:21:56,374 --> 02:21:59,077 BRIGHTER RED IS INDICATE OF 2601 02:21:59,143 --> 02:22:09,654 BINDINGS TO THE MICROGLIAL WE 2602 02:22:13,691 --> 02:22:21,099 CAN INDUCE AND CAN USE CAPSAICIN 2603 02:22:21,165 --> 02:22:24,235 AND AN OBJECTIVE MEASURE AND IN 2604 02:22:24,302 --> 02:22:25,403 FIGURE 3 WE'VE SHOWN EARLIER THE 2605 02:22:25,470 --> 02:22:28,940 DOSES OF THC CAN MODULATE THIS 2606 02:22:29,007 --> 02:22:29,340 EFFECT. 2607 02:22:29,407 --> 02:22:33,344 LOW DOSE AND HIGH DOSE OF THC 2608 02:22:33,411 --> 02:22:35,413 THERE'S A VARIABLE RESPONSE TO 2609 02:22:35,480 --> 02:22:36,748 THE HYPERALGESIA. 2610 02:22:36,814 --> 02:22:40,885 IN TERMS OF OUR STUDY SO PBR28 2611 02:22:40,952 --> 02:22:46,124 IS A LIGAND THAT BIND TO 2612 02:22:46,190 --> 02:22:48,626 ACTIVATION AND THE GENOTYPIC 2613 02:22:48,693 --> 02:22:50,995 RESPONSE AND BINDERS CAN BE 2614 02:22:51,062 --> 02:22:53,831 INCLUDED IN THE STUDY BUT 2615 02:22:53,898 --> 02:22:56,834 EXCLUDE THE BINDERS AND SUBJECT 2616 02:22:56,901 --> 02:22:59,404 TO HEALTHY PEOPLE WHO UNDER GO 2617 02:22:59,470 --> 02:23:01,139 MRI SCAN AT BASELINE CAPSAICIN 2618 02:23:01,205 --> 02:23:09,347 TEST AND HAVE A SCHEDULE OF A 2619 02:23:09,414 --> 02:23:14,552 10-DAY REGIMENT OF CANNABIDIOL 2620 02:23:14,619 --> 02:23:18,723 AND THE DOSING OF CBD AND THE 2621 02:23:18,790 --> 02:23:21,459 RANDOMIZED TRIAL SOME ED CBC AND 2622 02:23:21,526 --> 02:23:24,295 IN DAY 10 AND 11 OF THE STUDY 2623 02:23:24,362 --> 02:23:29,334 THEY UNDER GO THE PARADIGM WITH 2624 02:23:29,400 --> 02:23:32,370 MICROGLIAL ACTIVATION AND 2625 02:23:32,437 --> 02:23:36,007 MEASURE AND CONDUCT THE 2626 02:23:36,074 --> 02:23:37,875 CAPSAICIN SKIN TEST AND LOOK AT 2627 02:23:37,942 --> 02:23:44,415 THE ACTIVATION OF THE THALAMUS 2628 02:23:44,482 --> 02:23:47,885 AND WHAT WE CAN DETECT. 2629 02:23:47,952 --> 02:23:49,420 AGAIN THE STUDY HAS REGULATORY 2630 02:23:49,487 --> 02:23:54,759 CHALLENGES WE HAVE TO OVERCOME 2631 02:23:54,826 --> 02:23:59,364 AND SHORTAGES OF LPS AND SOME 2632 02:23:59,430 --> 02:24:00,565 REGULATORY ASPECTS WE'RE STILL 2633 02:24:00,631 --> 02:24:03,401 TRYING TO OVERCOME BUT ONE OF 2634 02:24:03,468 --> 02:24:05,003 THE THINGS THE PRELIMINARY STUDY 2635 02:24:05,069 --> 02:24:10,808 OF RESULTS IS THAT OUR MODEL CAN 2636 02:24:10,875 --> 02:24:15,380 CAPTURE HYPERALGESIA AND WE 2637 02:24:15,446 --> 02:24:20,318 MEASURE SENSITIVE TO THE MEASURE 2638 02:24:20,385 --> 02:24:21,252 OF HYPERALGESIA AND MICROGLIAL 2639 02:24:21,319 --> 02:24:23,955 ACTIVATION AND YOU GET A 2640 02:24:24,022 --> 02:24:25,289 RESPONSE IN THE ACTIVATION AND 2641 02:24:25,356 --> 02:24:28,326 WE DRAW EFFECTS AGAINST THE 2642 02:24:28,393 --> 02:24:30,361 STRONG SAMPLE SIZE AND IT'S 2643 02:24:30,428 --> 02:24:33,331 EARLY DAYS BUT WE STILL ARE 2644 02:24:33,398 --> 02:24:35,233 EXCITED ABOUT THIS RESULT. 2645 02:24:35,299 --> 02:24:37,335 SO FUTURE STEPS IS STUDY 2646 02:24:37,402 --> 02:24:39,137 COMPLETION WHICH IS THE BIGGEST 2647 02:24:39,203 --> 02:24:40,505 CHALLENGE. 2648 02:24:40,571 --> 02:24:41,272 I THINK IT'S IMPORTANT TO 2649 02:24:41,339 --> 02:24:44,976 VALIDATE THE FINDINGS IN 2650 02:24:45,043 --> 02:24:45,910 PATIENTS WITH CHRONIC PAIN AND 2651 02:24:45,977 --> 02:24:47,345 STUDY HEALTHY PEOPLE AS A 2652 02:24:47,412 --> 02:24:49,013 DIFFERENT POPULATION THAN THOSE 2653 02:24:49,080 --> 02:24:49,947 IN CHRONIC PAIN. 2654 02:24:50,014 --> 02:24:53,351 ONE OF THE THINGS THAT STANDS 2655 02:24:53,418 --> 02:24:55,319 OUT IS VARIABILITY AND IT'S 2656 02:24:55,386 --> 02:24:56,287 IMPORTANT TO RECOGNIZE 2657 02:24:56,354 --> 02:24:58,890 PREDICTORS OF PAIN BECAUSE NOT 2658 02:24:58,956 --> 02:24:59,757 EVERYBODY HAS THE SAME RESPONSE 2659 02:24:59,824 --> 02:25:06,998 AND THE FOURTH ASPECT I THINK IS 2660 02:25:07,065 --> 02:25:09,200 IMPORTANT IS TO CONSIDER 2661 02:25:09,267 --> 02:25:11,869 NON-CLINICAL FACTORS AND LOOK AT 2662 02:25:11,936 --> 02:25:13,204 SLEEP, ANXIETY AND STRESS AND 2663 02:25:13,271 --> 02:25:15,940 THESE ARE THINGS WE ARE 2664 02:25:16,007 --> 02:25:16,707 MEASURING. 2665 02:25:16,774 --> 02:25:18,943 THANK YOU AGAIN AND THANK YOU TO 2666 02:25:19,010 --> 02:25:20,111 NCCIH FOR YOUR SUPPORT FOR WHICH 2667 02:25:20,178 --> 02:25:22,213 THE WORK WOULDN'T BE POSSIBLE 2668 02:25:22,280 --> 02:25:23,214 WITHOUT THAT AND THANK YOU FOR 2669 02:25:23,281 --> 02:25:27,752 ALLOWING ME TO PRESENT TODAY. 2670 02:25:27,819 --> 02:25:33,691 >> THANK YOU, DR. RADHAKRISHNAN. 2671 02:25:33,758 --> 02:25:34,358 THANK YOU. 2672 02:25:34,425 --> 02:25:35,426 SUCH INTERESTING PRESENTATIONS 2673 02:25:35,493 --> 02:25:37,328 AND I HONESTLY HAVE QUESTIONS 2674 02:25:37,395 --> 02:25:39,831 BUT I'M GOING TO ACTUALLY OPEN 2675 02:25:39,897 --> 02:25:42,300 IT UP TO EVERYONE ELSE. 2676 02:25:42,366 --> 02:25:45,303 I THINK WE HAVE TIME FOR TWO TO 2677 02:25:45,369 --> 02:25:45,937 THREE QUESTIONS. 2678 02:25:46,003 --> 02:25:48,206 STEP UP TO THE MIC, ANYONE WITH 2679 02:25:48,272 --> 02:25:49,040 QUESTIONS? 2680 02:25:49,107 --> 02:25:50,842 DON'T BE SHY. 2681 02:25:50,908 --> 02:25:57,215 OTHERWISE I WILL MONOPOLIZE THE 2682 02:25:57,281 --> 02:25:57,515 MICROPHONE. 2683 02:25:57,582 --> 02:25:57,682 NO? 2684 02:25:57,748 --> 02:25:58,149 SOMEONE'S GETTING UP. 2685 02:25:58,216 --> 02:26:07,759 ALL RIGHT. 2686 02:26:07,825 --> 02:26:11,162 >> ONE THING I NOTICED ABOUT THE 2687 02:26:11,229 --> 02:26:13,097 CLINICAL AND PRE-CLINICAL IS THE 2688 02:26:13,164 --> 02:26:13,798 COMPARATORS ACROSS THE BOARD IN 2689 02:26:13,865 --> 02:26:17,335 DIFFERENT STUDIES. 2690 02:26:17,401 --> 02:26:21,339 WE SAW SOME PEOPLE USING 2691 02:26:21,405 --> 02:26:23,074 BUPRENORPHINE AND IN HUMAN 2692 02:26:23,141 --> 02:26:24,675 STUDIES WE HAD FEWER 2693 02:26:24,742 --> 02:26:24,976 COMPETITORS. 2694 02:26:25,042 --> 02:26:26,944 IT MAY BE INTERESTING TO THINK 2695 02:26:27,011 --> 02:26:29,380 ABOUT THE COMPARATORS IS GOING 2696 02:26:29,447 --> 02:26:31,115 TO CHANGE BASED ON THE PAIN 2697 02:26:31,182 --> 02:26:33,117 MODEL AND THE CANNABINOID AND 2698 02:26:33,184 --> 02:26:34,852 THE MECHANISM OF ACTION. 2699 02:26:34,919 --> 02:26:36,154 BUT IT MAY BE INTERESTING TO 2700 02:26:36,220 --> 02:26:39,624 THINK ABOUT A UNIFORM WAY OR 2701 02:26:39,690 --> 02:26:45,163 SYSTEMATIC WAY WHERE WE CAN HAVE 2702 02:26:45,229 --> 02:26:47,765 STANDARD COMPARATORS TO ASSESS 2703 02:26:47,832 --> 02:26:49,600 THE DIFFERENT CANNABIS 2704 02:26:49,667 --> 02:26:51,969 CONSTITUENTS THAT LOOK AT THEIR 2705 02:26:52,036 --> 02:26:54,539 EFFECTIVENESS, EFFICACY, 2706 02:26:54,605 --> 02:26:55,506 WHATEVER YOU WANT TO CALL IT 2707 02:26:55,573 --> 02:26:56,407 ACROSS THE MODELS. 2708 02:26:56,474 --> 02:26:57,341 A GENERAL QUESTION AND 2709 02:26:57,408 --> 02:26:59,610 OBSERVATION. 2710 02:26:59,677 --> 02:27:02,280 >> THIS IS A WONDERFUL QUESTION 2711 02:27:02,346 --> 02:27:03,981 ESPECIALLY BECAUSE WE HAVE A.I. 2712 02:27:04,048 --> 02:27:06,951 AND COMPUTATIONAL EXPERTS. 2713 02:27:07,018 --> 02:27:09,987 SO CAN WE HAVE SOME OPINIONS OR 2714 02:27:10,054 --> 02:27:14,325 PRELIMINARY THOUGHTS ON HOW WE 2715 02:27:14,392 --> 02:27:23,868 CAN MAKE IT IN A HIGH THROUGHPUT 2716 02:27:23,935 --> 02:27:27,738 COLLEAGUES WHO USE A.I. OR 2717 02:27:27,805 --> 02:27:28,306 HIGH-COMPUTATIONAL MODELS. 2718 02:27:28,372 --> 02:27:29,674 >> I DON'T HAVE AN ANSWER TO THE 2719 02:27:29,740 --> 02:27:34,378 QUESTION BUT I'M GOING TO ADD A 2720 02:27:34,445 --> 02:27:36,047 WRINKLE OF COMPLEXITY IS THE 2721 02:27:36,113 --> 02:27:39,183 ISSUE OF BLINDING IN HUMAN 2722 02:27:39,250 --> 02:27:40,218 STUDIES PEOPLE KNOW WHAT THEIR 2723 02:27:40,284 --> 02:27:47,825 PLACEBO IS BECAUSE OF THE SIDE 2724 02:27:47,892 --> 02:27:48,192 EFFECTS. 2725 02:27:48,259 --> 02:27:48,526 AND AND. 2726 02:27:48,593 --> 02:27:50,561 THE OTHER ASPECT WE NEED TO 2727 02:27:50,628 --> 02:27:53,364 THINK ABOUT IS SOMETHING THAT 2728 02:27:53,431 --> 02:28:02,940 CAN BE BLINDING AND IMPROVED. 2729 02:28:03,007 --> 02:28:06,377 >> WHEN WE SEARCH FOR TARGETS 2730 02:28:06,444 --> 02:28:11,515 AND BIND MANY TARGETS SO I 2731 02:28:11,582 --> 02:28:12,783 HAVEN'T SEEN A DRUG THAT EFFECTS 2732 02:28:12,850 --> 02:28:16,787 ONLY ONE RECEPTOR. 2733 02:28:16,854 --> 02:28:19,390 IT'S A BIO AVAILABILITY AND 2734 02:28:19,457 --> 02:28:22,560 BINDING ABILITY. 2735 02:28:22,627 --> 02:28:23,861 SO WHEN YOU LOOK AT FORMULATION 2736 02:28:23,928 --> 02:28:26,998 IT BECOMES A GAME OF HOW TO PUT 2737 02:28:27,064 --> 02:28:28,833 THINGS TOGETHER SO YOU TARGET A 2738 02:28:28,899 --> 02:28:31,869 PARTICULAR SET OF RECEPTORS 2739 02:28:31,936 --> 02:28:34,538 VERSUS LIKE OTHER UNDESIRABLE 2740 02:28:34,605 --> 02:28:36,707 EFFECTS. 2741 02:28:36,774 --> 02:28:37,842 SO I THINK AT LEAST LISTENING TO 2742 02:28:37,908 --> 02:28:39,310 THE MEETING IS AMAZING BECAUSE 2743 02:28:39,377 --> 02:28:40,911 THERE'S INFORMATION ABOUT ALL 2744 02:28:40,978 --> 02:28:42,213 THE STUDIES AND I THINK IT'S 2745 02:28:42,280 --> 02:28:47,685 TIME TO CONNECT ALL OF THIS TO 2746 02:28:47,752 --> 02:28:49,587 SMALL MOLECULE TO THE EFFECTS. 2747 02:28:49,654 --> 02:28:50,988 MAYBE THERE CAN BE AN INITIATIVE 2748 02:28:51,055 --> 02:28:56,027 TO PUT THINGS TOGETHER AS A SORT 2749 02:28:56,093 --> 02:28:59,163 OF MAJOR DATA BANK WE CAN USE 2750 02:28:59,230 --> 02:29:04,001 FOR THE MODELS BASED FROM SMALL 2751 02:29:04,068 --> 02:29:06,437 MOLECULES TO THE EFFECTS. 2752 02:29:06,504 --> 02:29:06,871 >> GREAT SUGGESTION. 2753 02:29:06,937 --> 02:29:09,340 WE HEAR YOU. 2754 02:29:09,407 --> 02:29:15,980 ESPECIALLY NOW BECAUSE NOW WE 2755 02:29:16,047 --> 02:29:19,684 HAVE THE GRANTS. 2756 02:29:19,750 --> 02:29:26,557 WE HAVE A NEW SMSP POLICY. 2757 02:29:26,624 --> 02:29:29,894 YOU HAVE TO SHOW WHICH DATABASES 2758 02:29:29,960 --> 02:29:36,701 YOU WILL BE STORING YOUR DATA 2759 02:29:36,767 --> 02:29:37,234 IN. 2760 02:29:37,301 --> 02:29:39,804 IT HAS TO BE PUBLIC ACCESS 2761 02:29:39,870 --> 02:29:42,206 FOREVER IN A STANDARDIZED WAY SO 2762 02:29:42,273 --> 02:29:45,343 EVERYBODY CAN USE THE FORM OF 2763 02:29:45,409 --> 02:29:47,611 THE DATA COLLECTION. 2764 02:29:47,678 --> 02:29:49,647 SO IT WILL BE AVAILABLE FOR 2765 02:29:49,714 --> 02:29:51,382 EVERYBODY. 2766 02:29:51,449 --> 02:29:55,019 THIS IS A TIME TO THINK ABOUT 2767 02:29:55,086 --> 02:30:02,059 THE STANDARDIZED BIG DATA SET. 2768 02:30:02,126 --> 02:30:02,893 >> OKAY. 2769 02:30:02,960 --> 02:30:03,461 HOPEFULLY -- 2770 02:30:03,527 --> 02:30:05,329 >> SOMEONE IS ON ZOOM. 2771 02:30:05,396 --> 02:30:09,333 >> YES. 2772 02:30:09,400 --> 02:30:12,770 >> THANK YOU. 2773 02:30:12,837 --> 02:30:15,539 TWO COMMENTS. 2774 02:30:15,606 --> 02:30:17,408 ONE HAS TO DO WITH MACHINE 2775 02:30:17,475 --> 02:30:20,511 LEARNING HAS APPLIED TO MOUSE 2776 02:30:20,578 --> 02:30:23,347 BEHAVIOR AND THERE'S DATA ON 2777 02:30:23,414 --> 02:30:29,720 USING VON FREY FILAMENT TESTING 2778 02:30:29,787 --> 02:30:32,957 AND WE HAVE THE BLACK BOX OF 2779 02:30:33,023 --> 02:30:34,625 MACHINE LEARNING AND FOUND A 2780 02:30:34,692 --> 02:30:36,494 DIVERGENCE IN FINDINGS BETWEEN 2781 02:30:36,560 --> 02:30:39,163 THE VON FREY AND WHAT WE CAN 2782 02:30:39,230 --> 02:30:41,132 DETECT IN CHANGES IN THE 2783 02:30:41,198 --> 02:30:44,301 APPLICATION OF SOME OF THESE 2784 02:30:44,368 --> 02:30:45,736 AGENTS LIKE CBD FOR EXAMPLE WE 2785 02:30:45,803 --> 02:30:50,708 CANNOT SEE A SIGNAL ON ONE HAND 2786 02:30:50,775 --> 02:30:57,648 WITH VON FREY BUT REVERSAL OF 2787 02:30:57,715 --> 02:31:00,251 HYPERSENSITIVITY AND AS THE 2788 02:31:00,317 --> 02:31:02,319 KNEELED GOES FORWARD MAYBE 2789 02:31:02,386 --> 02:31:03,421 THERE'S UNIFORMITY IN BRINGING 2790 02:31:03,487 --> 02:31:05,222 TOGETHER WHAT WOULD BE STANDARDS 2791 02:31:05,289 --> 02:31:09,093 FOR SOME OF THESE EMERGING 2792 02:31:09,160 --> 02:31:09,393 TECHNIQUES. 2793 02:31:09,460 --> 02:31:13,898 AND THE FINAL POINT IS ABOUT CBC 2794 02:31:13,964 --> 02:31:17,334 OR POINTED OUT AS BEING UNIQUE 2795 02:31:17,401 --> 02:31:22,673 IN THE STUDIES AND WE DID A DEEP 2796 02:31:22,740 --> 02:31:24,141 DOSE RESPONSE IN THE SENSORY 2797 02:31:24,208 --> 02:31:25,643 NEURONS AND CBC WAS UNIQUE 2798 02:31:25,709 --> 02:31:29,880 AMONGST THE FOUR WE STUDIES 2799 02:31:29,947 --> 02:31:31,749 SHOWING A DISCREET DOSE RESPONSE 2800 02:31:31,816 --> 02:31:35,553 RELATIONSHIP WHICH PREDICTED A 2801 02:31:35,619 --> 02:31:37,254 SINGLE SITE OF ACTION DESPITE 2802 02:31:37,321 --> 02:31:37,922 THE DRUG TO EVERYONE WORKING ON 2803 02:31:37,988 --> 02:31:48,065 CBC. 2804 02:31:54,071 --> 02:31:56,173 >> FOR DR. COOPER I HAD A 2805 02:31:56,240 --> 02:31:57,875 QUESTION BECAUSE I THINK DURING 2806 02:31:57,942 --> 02:32:00,377 YOUR PRESENTATION IF I HEARD YOU 2807 02:32:00,444 --> 02:32:01,345 CORRECTLY YOU MADE A COMMENT 2808 02:32:01,412 --> 02:32:05,249 ABOUT THE FACT THAT YOU'RE USING 2809 02:32:05,316 --> 02:32:08,452 VAPORIZED PRODUCT AND IN SOME 2810 02:32:08,519 --> 02:32:10,187 WAYS THAT WAS NOT IDEAL AND 2811 02:32:10,254 --> 02:32:13,224 EXPAND WHY IT'S NOT IDEAL. 2812 02:32:13,290 --> 02:32:16,060 I GUESS I'M THINKING FROM THE 2813 02:32:16,126 --> 02:32:17,795 CLINICAL LENS ALWAYS ABOUT HOW 2814 02:32:17,862 --> 02:32:19,230 DO THESE STUDIES -- HOW WOULD 2815 02:32:19,296 --> 02:32:21,932 THEY BE TRANSLATED TO HUMAN USE 2816 02:32:21,999 --> 02:32:25,035 AND MY UNDERSTANDING STILL IS 2817 02:32:25,102 --> 02:32:26,370 POST PEOPLE'S USE OF CANNABIS 2818 02:32:26,437 --> 02:32:30,574 PRODUCT THE MAJORITY STILL 2819 02:32:30,641 --> 02:32:33,244 INHALE THOUGH THERE'S A GROWING 2820 02:32:33,310 --> 02:32:40,084 BODY OF PEOPLE USING EDIBLES. 2821 02:32:40,150 --> 02:32:43,888 WHY WAS IT UNDESIRABLE WHEN IT'S 2822 02:32:43,954 --> 02:32:46,023 CLOSELY TO HOW PEOPLE USE 2823 02:32:46,090 --> 02:32:48,359 CANNABIS FOR RECREATION OR PAIN 2824 02:32:48,425 --> 02:32:51,395 MANAGEMENT IS TRUE VAPOR. 2825 02:32:51,462 --> 02:32:54,832 IT'S PROBABLY GOING TO BE A LONG 2826 02:32:54,899 --> 02:32:59,603 DISCUSSION BUT CURIOUS WHY IT'S 2827 02:32:59,670 --> 02:33:04,842 NOT IDEAL AND WHY YOU THINK MORE 2828 02:33:04,909 --> 02:33:06,977 INVESTIGATORS DON'T USED 2829 02:33:07,044 --> 02:33:07,411 VAPORIZED PRODUCTS. 2830 02:33:07,478 --> 02:33:09,046 >> IT'S INTERESTING ON THE HEELS 2831 02:33:09,113 --> 02:33:10,414 OF THE ARTICLE OF WHAT'S 2832 02:33:10,481 --> 02:33:11,482 HAPPENING IN CANADA AND THE 2833 02:33:11,549 --> 02:33:15,653 NUMBER OF OLDER ADULTS THAT ARE 2834 02:33:15,719 --> 02:33:18,822 GOING TO THE EMERGENCY ROOM 2835 02:33:18,889 --> 02:33:20,791 AFTER USING EDIBLE CANNABIS 2836 02:33:20,858 --> 02:33:21,125 PRODUCTS. 2837 02:33:21,191 --> 02:33:24,194 THIS IS SOMETHING WE'RE BECOMING 2838 02:33:24,261 --> 02:33:25,429 INCREASINGLY AWARE OF AS MORE 2839 02:33:25,496 --> 02:33:27,698 STATES ARE LEGALIZING AND MORE 2840 02:33:27,765 --> 02:33:31,101 PEOPLE ARE USING EDIBLE PRODUCTS 2841 02:33:31,168 --> 02:33:32,670 THERE'S RISK ASSOCIATED WITH 2842 02:33:32,736 --> 02:33:33,337 ORAL USE. 2843 02:33:33,404 --> 02:33:38,876 AND IN MY HEAD I'M VERY TRAINED 2844 02:33:38,943 --> 02:33:41,345 TO THINK INHALED CANNABIS 2845 02:33:41,412 --> 02:33:46,917 BECAUSE OF THE POTENTIAL TOXIN 2846 02:33:46,984 --> 02:33:49,386 THAT ARE INHALED WHEN IT'S 2847 02:33:49,453 --> 02:33:54,425 COMBUSTED THERE'S THE ISSUES 2848 02:33:54,491 --> 02:34:02,933 WITH THAT AND THE QUESTION ABOUT 2849 02:34:03,000 --> 02:34:03,934 VAPORIZED CANNABINOIDS I THINK 2850 02:34:04,001 --> 02:34:06,470 IS STILL A BIG QUESTION AND HOW 2851 02:34:06,537 --> 02:34:11,241 IF WE'RE SEEING THIS BEING 2852 02:34:11,308 --> 02:34:15,179 TRANSLATED TO SOME CLINICALLY 2853 02:34:15,245 --> 02:34:18,515 USEFUL THERAPEUTIC THAT IS GOING 2854 02:34:18,582 --> 02:34:20,117 THROUGH SOME FDA PROCESS. 2855 02:34:20,184 --> 02:34:21,885 IN MY HEAD I DON'T HAVE A GOOD 2856 02:34:21,952 --> 02:34:24,555 TEMPLATE FOR THAT RIGHT NOW. 2857 02:34:24,622 --> 02:34:28,392 SO I KNOW THAT SOME PEOPLE ARE 2858 02:34:28,459 --> 02:34:30,394 LOOKING AT METERED DOSE INHALERS 2859 02:34:30,461 --> 02:34:33,330 BUT I THINK I'M USED TO THINKING 2860 02:34:33,397 --> 02:34:34,131 INHALED CANNABINOIDS ARE 2861 02:34:34,198 --> 02:34:36,800 PROBABLY NOT THE BEST WAY TO GO. 2862 02:34:36,867 --> 02:34:40,771 ALSO IF YOU THINK OF PHARMACO 2863 02:34:40,838 --> 02:34:44,975 KINETIC EFFECTS WE KNOW INHALED 2864 02:34:45,042 --> 02:34:51,448 DELTA 9THC THOUGH IT'S BETTER 2865 02:34:51,515 --> 02:34:52,983 TRITATABLE THAN ORAL YOU'LL HAVE 2866 02:34:53,050 --> 02:34:54,718 BETTER PAIN RELIEF THAT WON'T BE 2867 02:34:54,785 --> 02:34:56,587 SUSTAINED FOR LONGER PERIOD OF 2868 02:34:56,654 --> 02:34:56,787 TIME. 2869 02:34:56,854 --> 02:34:59,723 AT LEAST WE'VE SHOWN IT'S 2870 02:34:59,790 --> 02:35:03,827 ACCOMPANIED BY HIGHER RATES OF 2871 02:35:03,894 --> 02:35:07,631 INTOXICATION THAN ORALLY 2872 02:35:07,698 --> 02:35:11,101 ADMINISTERED DELTA9 THC WHERE 2873 02:35:11,168 --> 02:35:13,337 THE INTOXICATION IS NOT AS GREAT 2874 02:35:13,404 --> 02:35:15,239 AND FEWER LIABILITIES ARE AT 2875 02:35:15,305 --> 02:35:17,708 WORK BUT THESE ARE IMPORTANT 2876 02:35:17,775 --> 02:35:20,611 QUESTIONS AND THINK NCCIH IS 2877 02:35:20,678 --> 02:35:21,912 ABLE TO ANSWER THESE QUESTIONS 2878 02:35:21,979 --> 02:35:22,446 WITH THE FUNDING YOU'RE 2879 02:35:22,513 --> 02:35:28,052 PROVIDING. 2880 02:35:28,118 --> 02:35:29,319 >> THANK YOU. 2881 02:35:29,386 --> 02:35:30,721 BEFORE YOU STEP AWAY I'M CURIOUS 2882 02:35:30,788 --> 02:35:33,490 AND PERHAPS THIS IS SOMETHING 2883 02:35:33,557 --> 02:35:37,327 YOU DISCUSSED AT PREVIOUS 2884 02:35:37,394 --> 02:35:41,331 MEETINGS, WHY DID YOU CHOOSE 2885 02:35:41,398 --> 02:35:41,598 VAPORIZED? 2886 02:35:41,665 --> 02:35:45,302 >> I DIDN'T CHOOSE VAPORIZED, IT 2887 02:35:45,369 --> 02:35:46,003 CHOSE ME. 2888 02:35:46,070 --> 02:35:47,638 >> AH. 2889 02:35:47,705 --> 02:35:49,139 >> I'M SURE THE CLINICAL 2890 02:35:49,206 --> 02:35:49,707 RESEARCHERS HAVE THE SAME 2891 02:35:49,773 --> 02:35:51,842 EXPERIENCE WHERE A LOT OF THE 2892 02:35:51,909 --> 02:35:53,944 TIMES I DEVELOPED GRANT IDEAS 2893 02:35:54,011 --> 02:35:56,413 BASED OFF WHAT'S AVAILABLE AND 2894 02:35:56,480 --> 02:35:57,414 WHAT'S FEASIBLE. 2895 02:35:57,481 --> 02:36:01,085 SO WHAT WAS AVAILABLE WAS 2896 02:36:01,151 --> 02:36:02,619 INHALED TERPENES AND WHAT WAS 2897 02:36:02,686 --> 02:36:03,587 FEASIBLE FROM AN FDA PERSPECTIVE 2898 02:36:03,654 --> 02:36:06,156 AT THAT POINT IN TIME AT LEAST 2899 02:36:06,223 --> 02:36:13,330 THE PATH OF LEAST RESISTANCE WAS 2900 02:36:13,397 --> 02:36:14,531 INHALED BECAUSE PEOPLE ARE 2901 02:36:14,598 --> 02:36:18,869 EXPOSED BASED OFF THE 2902 02:36:18,936 --> 02:36:20,304 CONCENTRATIONS OF TERPENES AND 2903 02:36:20,370 --> 02:36:22,639 PUBLISHED IN PEER-REVIEWED 2904 02:36:22,706 --> 02:36:24,007 PUBLISH LITERATURE AND USED THE 2905 02:36:24,074 --> 02:36:24,374 CONCENTRATIONS. 2906 02:36:24,441 --> 02:36:26,543 I WAS ABLE TO SAY WE'RE NOT 2907 02:36:26,610 --> 02:36:31,348 INTRODUCING ADDITIONAL RISK TO 2908 02:36:31,415 --> 02:36:32,916 THE PARTICIPANTS BY EXPOSING 2909 02:36:32,983 --> 02:36:34,118 THEM TO THE DOSES AND THAT'S 2910 02:36:34,184 --> 02:36:35,953 PART OF THE REASON WHY. 2911 02:36:36,019 --> 02:36:37,888 IT'S NOT VERY SOPHISTICATED 2912 02:36:37,955 --> 02:36:38,155 REASONING. 2913 02:36:38,222 --> 02:36:38,555 >> IT MAKES SENSE. 2914 02:36:38,622 --> 02:36:42,826 THANK YOU. 2915 02:36:42,893 --> 02:36:43,894 >> MAYBE ONE LAST QUESTION. 2916 02:36:43,961 --> 02:36:47,698 >> MAYBE A REMARK. 2917 02:36:47,765 --> 02:36:50,200 >> IF YOU LOOK AT DOSE EFFECT 2918 02:36:50,267 --> 02:36:51,268 WHEN YOU LOOK AT WHAT'S BETWEEN 2919 02:36:51,335 --> 02:36:52,469 THE DOSE AND EFFECT IS THE 2920 02:36:52,536 --> 02:36:53,937 CONCENTRATION AND IT DEPENDS ON 2921 02:36:54,004 --> 02:36:55,239 THE FORMULATION YOU'RE USING. 2922 02:36:55,305 --> 02:36:57,407 I WAS WONDERING ALL THE PEOPLE 2923 02:36:57,474 --> 02:37:01,912 PUTTING MONEY IN CLINICAL TRIALS 2924 02:37:01,979 --> 02:37:05,482 ALSO DO PHARMACO KINETICS AND 2925 02:37:05,549 --> 02:37:09,353 YOU CAN DETERMINE BASED ON THE 2926 02:37:09,419 --> 02:37:09,987 CONCENTRATION IF SOMETHING WORKS 2927 02:37:10,053 --> 02:37:10,420 OR NOT. 2928 02:37:10,487 --> 02:37:11,355 AND ALSO WHY THERE ARE PEOPLE 2929 02:37:11,421 --> 02:37:13,690 THAT DO NOT RESPOND TO TO THE 2930 02:37:13,757 --> 02:37:15,959 DOSING AND PEOPLE THAT DO AND IF 2931 02:37:16,026 --> 02:37:20,130 YOU HAVE A NUMBER ON THE 2932 02:37:20,197 --> 02:37:20,998 CONCENTRATION YOU COULD LEARN 2933 02:37:21,064 --> 02:37:22,065 SOMETHING. 2934 02:37:22,132 --> 02:37:24,401 I'VE DONE A COUPLE NOT WITH 2935 02:37:24,468 --> 02:37:27,738 CANNABIS BUT WITH MANY STUDIES, 2936 02:37:27,805 --> 02:37:28,806 PRE CLINICAL AND MOUSE MODELS 2937 02:37:28,872 --> 02:37:34,077 AND HUMAN STUDIES AND WE ALWAYS 2938 02:37:34,144 --> 02:37:36,680 MEASURE PLASMA LEVELS BECAUSE WE 2939 02:37:36,747 --> 02:37:41,318 LEARN ABOUT ABSORPTION AND THE 2940 02:37:41,385 --> 02:37:43,487 METABOLISM BECAUSE SOME HAVE 2941 02:37:43,554 --> 02:37:44,087 DIFFERENT EFFECT. 2942 02:37:44,154 --> 02:37:46,089 IT'S JUST A COMMENT. 2943 02:37:46,156 --> 02:37:46,790 THANK YOU. 2944 02:37:46,857 --> 02:37:47,157 >> GOOD COMMENT. 2945 02:37:47,224 --> 02:37:47,491 GREAT. 2946 02:37:47,558 --> 02:37:51,995 THANK YOU. 2947 02:37:52,062 --> 02:37:54,064 I THINK -- YES. 2948 02:37:54,131 --> 02:37:55,699 >> SO ACTUALLY IF YOU COME UP 2949 02:37:55,766 --> 02:37:59,403 WITH MORE QUESTIONS, THIS IS 2950 02:37:59,469 --> 02:38:01,338 GREAT AND MORE THAN FINE. 2951 02:38:01,405 --> 02:38:06,343 WHAT WE PLANNED FOR THIS NEXT 40 2952 02:38:06,410 --> 02:38:08,445 MINUTES WOULD BE A COMBINATION 2953 02:38:08,512 --> 02:38:12,282 OF THE QUESTIONS THAT YOU CAN 2954 02:38:12,349 --> 02:38:14,785 ASK EACH OTHER PRE-CLINICAL AND 2955 02:38:14,852 --> 02:38:15,786 CLINICAL AND WHAT WE DID. 2956 02:38:15,853 --> 02:38:17,821 WE'RE ASKING EACH OF YOU TO 2957 02:38:17,888 --> 02:38:19,056 PROVIDE NEXT STEP FOR THE FIELD 2958 02:38:19,122 --> 02:38:22,092 FOR THE CELLS AND FOR THE FIELD. 2959 02:38:22,159 --> 02:38:24,995 AND THEN WE'LL SYNTHESIZE THEM 2960 02:38:25,062 --> 02:38:26,263 IN SEVERAL SLIDES SO ALL THE 2961 02:38:26,330 --> 02:38:28,465 SLIDES THAT YOU WILL SEE RIGHT 2962 02:38:28,532 --> 02:38:30,234 NOW THERE IS NOTHING NEW. 2963 02:38:30,300 --> 02:38:35,439 YOU ALREADY SAW ALL THE STEPS OR 2964 02:38:35,505 --> 02:38:36,173 DIRECTIONS YOU PROPOSED. 2965 02:38:36,240 --> 02:38:39,443 WE WOULD LIKE TO DO IN THE NEXT 2966 02:38:39,509 --> 02:38:45,082 40 MINUTES IS TO DISCUSS HOW WE 2967 02:38:45,148 --> 02:38:49,720 CAN ADDRESS IT. 2968 02:38:49,786 --> 02:38:50,654 WHAT ARE PRIORITIES TO PLAN 2969 02:38:50,721 --> 02:38:52,089 AHEAD FOR THE PROGRAM AND FOR 2970 02:38:52,155 --> 02:38:56,493 THE FIELD AND HOPEFULLY FOR YOUR 2971 02:38:56,560 --> 02:38:58,262 FUTURE COLLABORATIONS. 2972 02:38:58,328 --> 02:39:00,564 SO I HAVE THREE SLIDES THAT 2973 02:39:00,631 --> 02:39:01,365 SYNTHESIZE THE NEXT STEPS FOR 2974 02:39:01,431 --> 02:39:03,700 MORE CLINICAL STUDIES. 2975 02:39:03,767 --> 02:39:08,739 SO BASED ON WHAT YOU PROPOSED, 2976 02:39:08,805 --> 02:39:11,808 THESE ARE THE DIRECTIONS AND 2977 02:39:11,875 --> 02:39:13,911 PLANS FOR STUDIES THAT WILL BE 2978 02:39:13,977 --> 02:39:17,314 BASIC STUDIES OR PHARMACOLOGICAL 2979 02:39:17,381 --> 02:39:17,714 STUDIES. 2980 02:39:17,781 --> 02:39:24,288 SO YOU CAN SEE SOME OF THEM ARE 2981 02:39:24,354 --> 02:39:28,091 USING THE MODEL ON WHAT WOULD BE 2982 02:39:28,158 --> 02:39:33,330 THE BIGGEST GAP SO YOU CAN SEE 2983 02:39:33,397 --> 02:39:34,698 THESE AGAIN AND I WILL BE 2984 02:39:34,765 --> 02:39:38,335 SHOWING THEM BACK AND FORTH. 2985 02:39:38,402 --> 02:39:41,238 SO THE NEXT SLIDE IS YOUR 2986 02:39:41,305 --> 02:39:43,707 SUGGESTIONS FOR THE NEXT STEPS 2987 02:39:43,774 --> 02:39:47,010 RELATED TO THE POTENTIAL NEW 2988 02:39:47,077 --> 02:39:50,514 MODELS AND THINGS THAT CAN BE 2989 02:39:50,580 --> 02:39:52,482 GREATER RESOURCES IN THE FIELD. 2990 02:39:52,549 --> 02:39:56,219 SO HERE YOU CAN SEE ALL OTHER 2991 02:39:56,286 --> 02:39:58,422 PLANS BEYOND CANNABIS THAT CAN 2992 02:39:58,488 --> 02:40:04,461 BE SOURCE OF POTENTIAL 2993 02:40:04,528 --> 02:40:04,995 ANALGESICS. 2994 02:40:05,062 --> 02:40:07,731 THIS GREAT NEW DATABASE THAT I 2995 02:40:07,798 --> 02:40:11,101 THINK YOU WILL HAVE QUESTIONS 2996 02:40:11,168 --> 02:40:12,202 WITH IT AND CONSIDERING CREATORS 2997 02:40:12,269 --> 02:40:14,137 IN THE ROOM IS REALLY GREAT. 2998 02:40:14,204 --> 02:40:15,772 THE MOUSE MODELS. 2999 02:40:15,839 --> 02:40:17,975 THESE ARE THE THINGS YOU 3000 02:40:18,041 --> 02:40:20,711 PROPOSED AND WE CAN START 3001 02:40:20,777 --> 02:40:24,681 DISCUSSION ON HOW TO ADDRESS THE 3002 02:40:24,748 --> 02:40:24,982 STEPS. 3003 02:40:25,048 --> 02:40:31,521 HOW TO MAKE IT NOT 10 YEARS 3004 02:40:31,588 --> 02:40:32,889 PLANNED BUT THREE YEARS PLANNED 3005 02:40:32,956 --> 02:40:34,825 AND MECHANISTIC STUDIES. 3006 02:40:34,891 --> 02:40:38,462 FOR THE MECHANISTICS YOU CAN SEE 3007 02:40:38,528 --> 02:40:41,231 ALL THE POTENTIAL MECHANISMS 3008 02:40:41,298 --> 02:40:44,001 THAT ARE STILL UNDER STUDIED OR 3009 02:40:44,067 --> 02:40:48,872 COMPLETED NEW. 3010 02:40:48,939 --> 02:40:55,979 AND YOU CAN SEE THOR THE 3011 02:40:56,046 --> 02:40:59,683 SYNERGIES BETWEEN THE DIFFERENT 3012 02:40:59,750 --> 02:41:05,055 COMPONENTS OF THE HEMP MAYBE AND 3013 02:41:05,122 --> 02:41:10,060 HOW YOU CAN USE THEM AS DOSE 3014 02:41:10,127 --> 02:41:12,262 DEPENDENT AND TIME DEPENDENT FOR 3015 02:41:12,329 --> 02:41:14,631 RELATIONS IN RELATION TO PAIN. 3016 02:41:14,698 --> 02:41:17,334 IT'S STILL THE PROBLEM IS STILL 3017 02:41:17,401 --> 02:41:21,338 ABOUT NEW ANALGESICS. 3018 02:41:21,405 --> 02:41:23,206 COMPARE THE EFFECTS OF DIFFERENT 3019 02:41:23,273 --> 02:41:25,409 COMPOUNDS AND START THINKING 3020 02:41:25,475 --> 02:41:28,612 ABOUT WHAT DO WE MISS? 3021 02:41:28,678 --> 02:41:34,017 SO WE ALL HAVE SOME STUDIES 3022 02:41:34,084 --> 02:41:37,954 INVESTIGATING MINOR CANNABINOIDS 3023 02:41:38,021 --> 02:41:41,391 BETWEEN THEMSELVES AND THE 3024 02:41:41,458 --> 02:41:42,325 COMBINATION BETWEEN THE TWO. 3025 02:41:42,392 --> 02:41:44,761 IS THERE ANYTHING ELSE YOU WOULD 3026 02:41:44,828 --> 02:41:47,264 LIKE TO INVESTIGATE? 3027 02:41:47,330 --> 02:41:51,034 THE LAST WOULD BE TRANSLATION. 3028 02:41:51,101 --> 02:41:54,237 SO THESE ARE ALL SUGGESTIONS FOR 3029 02:41:54,304 --> 02:41:57,774 POTENTIAL TRANSLATIONAL STUDIES. 3030 02:41:57,841 --> 02:42:01,344 HOW YOU CAN INVESTIGATE THE 3031 02:42:01,411 --> 02:42:04,081 EFFICACY TO OPTIMIZE THE 3032 02:42:04,147 --> 02:42:08,452 THERAPEUTIC TRANSLATION. 3033 02:42:08,518 --> 02:42:10,821 WHAT POTENTIAL EVENTS FOR 3034 02:42:10,887 --> 02:42:13,557 CANNABIS CONSTITUENTS CAN OR 3035 02:42:13,623 --> 02:42:16,059 CANNOT BE USED IN HUMANS. 3036 02:42:16,126 --> 02:42:18,495 THE QUESTION IS IF THE 3037 02:42:18,562 --> 02:42:20,864 TRANSLATION POTENTIAL IS LOW 3038 02:42:20,931 --> 02:42:24,134 SHOULD WE STILL FUND THOSE 3039 02:42:24,201 --> 02:42:24,734 STUDIES? 3040 02:42:24,801 --> 02:42:28,972 HOW MUCH OF THE BASIC EFFECTS 3041 02:42:29,039 --> 02:42:31,975 ARE VARIABLE IF WE ARE NOT SURE 3042 02:42:32,042 --> 02:42:36,113 WHICH ONE CAN BE TRANSLATED TO 3043 02:42:36,179 --> 02:42:38,682 HUMAN STUDIES AND ANSWERING 3044 02:42:38,748 --> 02:42:41,218 OTHER QUESTIONS DO THEY CONTINUE 3045 02:42:41,284 --> 02:42:43,954 TO HAVE EFFECTS OF CANNABIS. 3046 02:42:44,020 --> 02:42:45,856 HOW WE CAN BETTER ADDRESS THE 3047 02:42:45,922 --> 02:42:48,091 INTERACTION EFFECTS. 3048 02:42:48,158 --> 02:42:49,726 SO THESE WOULD BE POTENTIAL 3049 02:42:49,793 --> 02:42:52,162 STEPS AND DIRECTIONS FOR 3050 02:42:52,229 --> 02:42:55,065 NON-CLINICAL. 3051 02:42:55,132 --> 02:42:57,868 THEN FROM OUR CLINICAL WE HEARD 3052 02:42:57,934 --> 02:43:01,872 ABOUT ALL THESE GREAT NEXT STEPS 3053 02:43:01,938 --> 02:43:03,440 AND SOME ARE ALL ABOUT 3054 02:43:03,507 --> 02:43:06,810 INDIVIDUALIZED PAIN THERAPY. 3055 02:43:06,877 --> 02:43:09,146 WE KNOW MANY OF THE CONSTITUENTS 3056 02:43:09,212 --> 02:43:11,148 HAVE SHOWN ANALGESIC PROPERTIES 3057 02:43:11,214 --> 02:43:11,948 ARE THEY FOR EVERYONE? 3058 02:43:12,015 --> 02:43:16,086 CAN THEY BE SEX-GENDER 3059 02:43:16,153 --> 02:43:17,220 DEPENDENT? 3060 02:43:17,287 --> 02:43:17,687 AGE DEPENDENT? 3061 02:43:17,754 --> 02:43:19,956 CAN THEY WORK DIFFERENTLY IN 3062 02:43:20,023 --> 02:43:21,791 DIFFERENT RACIAL OR ETHNIC 3063 02:43:21,858 --> 02:43:25,328 GROUPS DEPENDING ON BIOLOGY? 3064 02:43:25,395 --> 02:43:27,931 DEPENDING ON PURPOSES OF THE 3065 02:43:27,998 --> 02:43:28,365 CONSTITUENTS? 3066 02:43:28,431 --> 02:43:30,233 HOW TO ADDRESS THEM? 3067 02:43:30,300 --> 02:43:34,137 CAN WE PREDICT WHO WILL BE 3068 02:43:34,204 --> 02:43:37,240 RESPONDING BETTER TO THE DRUG 3069 02:43:37,307 --> 02:43:42,946 THAT IS A MAJOR PRODUCT AND SO 3070 02:43:43,013 --> 02:43:45,782 HOW THEY HAVE MANY PAIN 3071 02:43:45,849 --> 02:43:48,852 MECHANISMS AND WHAT WOULD BE THE 3072 02:43:48,919 --> 02:43:51,555 BEST WAY TO INVESTIGATE CANNABIS 3073 02:43:51,621 --> 02:43:54,791 IN THE BRAIN AND THE EFFECT ON 3074 02:43:54,858 --> 02:43:57,561 BRAIN VERSUS PERIPHERY? 3075 02:43:57,627 --> 02:43:59,729 P.K. STUDIES? 3076 02:43:59,796 --> 02:44:01,998 ALTERNATIVE MODES OF 3077 02:44:02,065 --> 02:44:02,365 ADMINISTRATION? 3078 02:44:02,432 --> 02:44:04,901 SO WE JUST STARTED THINKING 3079 02:44:04,968 --> 02:44:09,339 ABOUT VAPORIZED CANNABINOIDS 3080 02:44:09,406 --> 02:44:10,507 VERSUS EDIBLES. 3081 02:44:10,574 --> 02:44:13,310 MAYBE THERE'S OTHER INTERESTS. 3082 02:44:13,376 --> 02:44:14,177 UNDERSTANDING THE RELATIONSHIP 3083 02:44:14,244 --> 02:44:16,079 BETWEEN CHRONIC PAIN AND RELATED 3084 02:44:16,146 --> 02:44:19,482 FACTORS SUCH AS SLEEP, FATIGUE, 3085 02:44:19,549 --> 02:44:23,220 ANXIETY STRESS IN THE CONTEXT OF 3086 02:44:23,286 --> 02:44:23,553 CANNABINOIDS. 3087 02:44:23,620 --> 02:44:25,956 SO THESE ARE ALL INTERESTING 3088 02:44:26,022 --> 02:44:30,760 NEXT STEPS FOR CLINICAL STUDIES 3089 02:44:30,827 --> 02:44:32,829 THAT CAN BE ON THE PRE-CLINICAL 3090 02:44:32,896 --> 02:44:34,831 LEVEL AND FOR CLINICAL STUDIES 3091 02:44:34,898 --> 02:44:37,200 WE HAVE SO MANY CHALLENGES. 3092 02:44:37,267 --> 02:44:39,169 PATIENT COMMITMENT, PATIENT 3093 02:44:39,236 --> 02:44:41,738 ENGAGEMENT, DRUG RELIABILITY AND 3094 02:44:41,805 --> 02:44:42,205 TESTING. 3095 02:44:42,272 --> 02:44:45,342 WE HAVE HERE IN ONE PARTICULAR 3096 02:44:45,408 --> 02:44:49,746 STUDY THAT HAD TWO ISSUES WITH 3097 02:44:49,813 --> 02:44:52,082 FDA CLINICAL HOPES. 3098 02:44:52,148 --> 02:45:02,392 TWO, NOT ONE. 3099 02:45:19,609 --> 02:45:21,177 WE WILL HAVE RECORDINGS AT THE 3100 02:45:21,244 --> 02:45:24,781 NEXT PORTION OF THE MEETING WITH 3101 02:45:24,848 --> 02:45:27,417 QUESTIONS THAT WE CAN START 3102 02:45:27,484 --> 02:45:27,951 ADDRESSING. 3103 02:45:28,018 --> 02:45:29,119 PLACEBO EFFECTS AND REGRESSION 3104 02:45:29,185 --> 02:45:30,787 TO THE MEAN AS A CHALLENGE IN 3105 02:45:30,854 --> 02:45:33,757 THE CLINICAL STUDIES AND OF 3106 02:45:33,823 --> 02:45:35,759 COURSE DRUG SHORTAGES. 3107 02:45:35,825 --> 02:45:39,296 WE WILL HAVE AT LEAST TWO 3108 02:45:39,362 --> 02:45:44,668 OPINIONS ON HOW TO ADDRESS THEM 3109 02:45:44,734 --> 02:45:50,307 FROM THE PROGRAM. 3110 02:45:50,373 --> 02:45:53,810 THESE ARE THE CHALLENGES AND NEW 3111 02:45:53,877 --> 02:45:55,512 DIRECTIONS THAT YOU ALL 3112 02:45:55,578 --> 02:45:55,912 SUGGESTED? 3113 02:45:55,979 --> 02:45:59,816 WE HAVE TWO MICROPHONES AND MORE 3114 02:45:59,883 --> 02:46:01,318 MICROPHONES AT THE TABLE. 3115 02:46:01,384 --> 02:46:11,928 SO IT WOULD BE GREAT IF THROWS 3116 02:46:13,129 --> 02:46:14,164 WHO HAVE OPINIONS, SUGGESTIONS 3117 02:46:14,230 --> 02:46:15,198 CAN COME TO THE MICROPHONE. 3118 02:46:15,265 --> 02:46:16,066 DON'T BE SHY. 3119 02:46:16,132 --> 02:46:17,267 THIS IS YOUR MEETING AND THE 3120 02:46:17,334 --> 02:46:23,006 FINAL MEETING SO IF YOU WANT 3121 02:46:23,073 --> 02:46:25,342 THIS PROGRAM TO ADDRESS NEW 3122 02:46:25,408 --> 02:46:27,210 DIRECTION AND COME UP WITH NEW 3123 02:46:27,277 --> 02:46:29,245 STEPS, PLEASE SUGGEST THEM NOW. 3124 02:46:29,312 --> 02:46:34,517 SO THESE ARE CHALLENGES AND 3125 02:46:34,584 --> 02:46:37,120 STEPS FOR CLINICAL STUDIES. 3126 02:46:37,187 --> 02:46:41,124 IDEAS FOR POTENTIAL TRANSLATION 3127 02:46:41,191 --> 02:46:45,328 AND IDEAS ON POTENTIAL NEW 3128 02:46:45,395 --> 02:46:45,628 MECHANISMS. 3129 02:46:45,695 --> 02:46:50,266 IDEAS ON RESOURCES AND BASIC AND 3130 02:46:50,333 --> 02:46:51,267 PHARMACOLOGIC STUDIES. 3131 02:46:51,334 --> 02:46:54,304 AND NOW I WELCOME YOU ALL. 3132 02:46:54,371 --> 02:46:57,307 PLEASE JUST START THE COVERING. 3133 02:46:57,374 --> 02:47:07,650 -- CONVERSATION. 3134 02:47:23,867 --> 02:47:26,269 >> THIS RELATES TO ZIVA'S 3135 02:47:26,336 --> 02:47:31,941 QUESTION AND I WAS TALKING TO A 3136 02:47:32,008 --> 02:47:33,009 COLLEAGUE AND TELLING ME ABOUT A 3137 02:47:33,076 --> 02:47:34,978 PROGRAM WITH PRE-CLINICAL STROKE 3138 02:47:35,044 --> 02:47:35,578 RESEARCHERS AND STROKE 3139 02:47:35,645 --> 02:47:39,315 SCIENTISTS THROUGHOUT THE 3140 02:47:39,382 --> 02:47:44,687 COUNTRY ARE STANDARDIZING THEIR 3141 02:47:44,754 --> 02:47:47,924 ASSAYS IN A WAY WHERE FOLKS ARE 3142 02:47:47,991 --> 02:47:53,663 TRAINED AT DIFFERENT SITES. 3143 02:47:53,730 --> 02:47:59,669 SAY I DO CIP N AND HE TRAINS ON 3144 02:47:59,736 --> 02:48:01,337 CIPN AND WE DECIDE A WAY TO DO 3145 02:48:01,404 --> 02:48:05,341 IT WITH VON FREY OR OTHER COOL 3146 02:48:05,408 --> 02:48:10,079 SOPHISTICATED WAYS. 3147 02:48:10,146 --> 02:48:20,690 WE STANDARDIZED THE SEX WHETHER 3148 02:48:22,559 --> 02:48:27,931 MALE OR FEMALE AND CBD IS 3149 02:48:27,997 --> 02:48:29,699 PROVIDED AND TESTED AND 3150 02:48:29,766 --> 02:48:31,301 ELIMINATE THE VARIABILITY. 3151 02:48:31,367 --> 02:48:33,670 HALF OF ME THINKS THAT'S VERY 3152 02:48:33,736 --> 02:48:35,772 COOL AS A WAY TO ADD STRENGTH TO 3153 02:48:35,839 --> 02:48:38,374 OUR RESEARCH AND TRANSLATE IT 3154 02:48:38,441 --> 02:48:40,844 ACROSS LABS BUT THEN I ALSO FEEL 3155 02:48:40,910 --> 02:48:48,184 LIKE IT TAKES AWAY PERHAPS SOME 3156 02:48:48,251 --> 02:48:49,953 OF THE NOVELTY AND INNOVATION 3157 02:48:50,019 --> 02:48:51,721 AND DOING THINGS IN A DIFFERENT 3158 02:48:51,788 --> 02:48:52,021 WAY. 3159 02:48:52,088 --> 02:48:53,323 I HAVE THOSE TWO IDEAS BOUNCING 3160 02:48:53,389 --> 02:49:00,363 AROUND IN MY HEAD AND TO ADDRESS 3161 02:49:00,430 --> 02:49:06,236 ZIVA'S POINT, WITH CONTROL 3162 02:49:06,302 --> 02:49:13,343 COMPOUNDS TO LOOK AT HOW SIMILAR 3163 02:49:13,409 --> 02:49:15,445 OUR COMPOUNDS AND WHAT DOES THE 3164 02:49:15,512 --> 02:49:21,351 DOSE MORPHINE LOOK LIKE AND 3165 02:49:21,417 --> 02:49:27,824 THOUGH WE CAN AGREE WE DO OUR 3166 02:49:27,891 --> 02:49:35,064 ASSAYS A LITTLE BIT DIFFERENTLY 3167 02:49:35,131 --> 02:49:37,867 WE CAN LOOK AT THIS ASSAY WHERE 3168 02:49:37,934 --> 02:49:39,202 MORPHINE LOOKS LIKE THIS AND 3169 02:49:39,269 --> 02:49:40,069 THESE ARE THINGS I WAS THINKING 3170 02:49:40,136 --> 02:49:46,009 ABOUT. 3171 02:49:46,075 --> 02:49:56,252 >> APRIL. 3172 02:50:12,702 --> 02:50:20,710 >> I SPENT THE LAST 20 YEARS AND 3173 02:50:20,777 --> 02:50:26,649 I WAS STRUCK BY IS HOW 3174 02:50:26,716 --> 02:50:27,483 HETEROGENOUS THE VIEWS ARE AND 3175 02:50:27,550 --> 02:50:32,855 MY EXPERTISE AND BRINGING TO THE 3176 02:50:32,922 --> 02:50:38,061 TABLE INVESTIGATOR ENVIRONMENT 3177 02:50:38,127 --> 02:50:40,997 AND HOW THEY ARE USED 3178 02:50:41,064 --> 02:50:41,297 CLINICALLY. 3179 02:50:41,364 --> 02:50:42,465 IT'S GREAT AND IF YOU'RE GOING 3180 02:50:42,532 --> 02:50:44,601 TO DO THAT YOU'RE GOING TO ASK 3181 02:50:44,667 --> 02:50:49,872 DIFFERENT QUESTIONS TO DEVELOP A 3182 02:50:49,939 --> 02:50:53,876 BETTER METHOD FOR AND DRUG 3183 02:50:53,943 --> 02:50:55,612 COMPANIES LOOK AT THIS ALL THE 3184 02:50:55,678 --> 02:50:58,281 TIME AND LIKELY TO LOOK AT THE 3185 02:50:58,348 --> 02:51:02,018 MAJORITY OF THE FUNDING RELATED 3186 02:51:02,085 --> 02:51:04,087 TO DISEASE OR TREATMENT 3187 02:51:04,153 --> 02:51:14,330 RESPONSE. 3188 02:51:26,242 --> 02:51:31,347 >> YOU CAN'T ANSWER THE QUESTION 3189 02:51:31,414 --> 02:51:34,384 WITHOUT BEING CLEAR OF WHAT THE 3190 02:51:34,450 --> 02:51:36,552 GOAL IS AND YOU FUND STUDIES 3191 02:51:36,619 --> 02:51:40,089 INVOLVING BASIC SCIENCE AND 3192 02:51:40,156 --> 02:51:42,291 CLEARLY THAT HAVE A LONG-TERM 3193 02:51:42,358 --> 02:51:43,259 GOAL IN THE TREATMENTS BEING 3194 02:51:43,326 --> 02:51:44,961 AVAILABLE ACROSS THE BOARD, HOW 3195 02:51:45,028 --> 02:51:47,030 DO YOU FEEL WHEN YOU GET 3196 02:51:47,096 --> 02:51:48,097 APPLICATIONS THAT HAVE THESE 3197 02:51:48,164 --> 02:51:49,766 DIFFERENT END POINTS GIVEN YOU 3198 02:51:49,832 --> 02:51:54,737 HAVE SO MANY DIFFERENT 3199 02:51:54,804 --> 02:52:05,348 PERSPECTIVES YOU MUST CONSIDER 3200 02:52:05,915 --> 02:52:09,619 AND I'LL TURN MY QUESTION BACK 3201 02:52:09,686 --> 02:52:10,053 TO YOU. 3202 02:52:10,119 --> 02:52:12,088 >> OKAY. 3203 02:52:12,155 --> 02:52:13,189 SO JUST KEEP IN MIND WE'LL BE 3204 02:52:13,256 --> 02:52:15,591 NOT THE FIRST TO SEE 3205 02:52:15,658 --> 02:52:15,892 APPLICATION. 3206 02:52:15,958 --> 02:52:20,396 WE WILL HAVE THE STUDY SECTION 3207 02:52:20,463 --> 02:52:23,533 WITH YOUR COLLEAGUES AND EXPERTS 3208 02:52:23,599 --> 02:52:25,468 IN THE FIELD AND THEY WILL 3209 02:52:25,535 --> 02:52:28,705 REVIEW MANY ASPECTS OF THE 3210 02:52:28,771 --> 02:52:29,305 STUDY. 3211 02:52:29,372 --> 02:52:32,208 AS ALWAYS YOU ALL KNOW THEY'LL 3212 02:52:32,275 --> 02:52:33,643 BE LOOKING AT THE THREE MAIN 3213 02:52:33,710 --> 02:52:33,943 CATEGORIES. 3214 02:52:34,010 --> 02:52:43,186 ONE IS THE NOVELTY OF THE IDEAS. 3215 02:52:43,252 --> 02:52:47,790 LOOK AT WHAT WAS ALREADY FUNDED 3216 02:52:47,857 --> 02:52:50,126 FOR THE SPECIFIC AREA YOU'RE 3217 02:52:50,193 --> 02:52:50,526 INTERESTED. 3218 02:52:50,593 --> 02:52:53,830 SO NOVELTY IF IT'S THE MECHANISM 3219 02:52:53,896 --> 02:52:55,932 THEN IT SHOULD BE SOMETHING 3220 02:52:55,998 --> 02:52:58,935 INNOVATIVE WITHIN THE MECHANISM. 3221 02:52:59,001 --> 02:53:05,308 IT COULD BE NOVELTY ASPECTS. 3222 02:53:05,374 --> 02:53:06,642 ANOTHER THEME WOULD BE WHO IS 3223 02:53:06,709 --> 02:53:11,848 YOUR TEAM OF INVESTIGATORS AND 3224 02:53:11,914 --> 02:53:13,249 THE EXPERTISE FOR DIFFERENT 3225 02:53:13,316 --> 02:53:14,917 EXPERIMENTS AND AIMS THAT YOU 3226 02:53:14,984 --> 02:53:18,988 PROPOSE IN THE STUDY AND DO YOU 3227 02:53:19,055 --> 02:53:20,857 HAVE THE HISTORY OF 3228 02:53:20,923 --> 02:53:21,324 COLLABORATION. 3229 02:53:21,390 --> 02:53:26,729 WHO WILL BE DOING THE WORK? 3230 02:53:26,796 --> 02:53:28,698 THIS IS ANOTHER ASPECT AND THE 3231 02:53:28,765 --> 02:53:31,634 THIRD IS HOW THE EXPERIMENTS 3232 02:53:31,701 --> 02:53:32,668 THAT YOU PROPOSE ARE FEASIBLE 3233 02:53:32,735 --> 02:53:38,741 AND CAN YOU DO IT IN THREE OR 3234 02:53:38,808 --> 02:53:44,680 FIVE YEARS AND HOW THEY'LL BE 3235 02:53:44,747 --> 02:53:46,115 ADDRESSING THE MAIN AIMS YOU 3236 02:53:46,182 --> 02:53:46,349 PROPOSE. 3237 02:53:46,415 --> 02:53:56,959 AND THEN IT COMES TO US AND THEN 3238 02:53:58,261 --> 02:54:01,898 AT THE LAST SESSION WE'LL HAVE 3239 02:54:01,964 --> 02:54:03,699 COLLEAGUES FROM NCCIH TALKING 3240 02:54:03,766 --> 02:54:04,934 ABOUT THEIR PARTICULAR INSTITUTE 3241 02:54:05,001 --> 02:54:09,338 OR CENTER PRIORITIES IN FUNDING 3242 02:54:09,405 --> 02:54:11,674 CANNABIS RESEARCH THAT WILL BE 3243 02:54:11,741 --> 02:54:13,309 DIFFERENT AND WE'RE MOSTLY 3244 02:54:13,376 --> 02:54:15,111 INTERESTED IN THE ANALGESIC 3245 02:54:15,178 --> 02:54:19,682 PROPERTIES OF MINOR CANNABINOIDS 3246 02:54:19,749 --> 02:54:28,124 AND WE ALLOW STUDIES ON THC ON 3247 02:54:28,191 --> 02:54:32,261 CANNABINOIDS AND THIS IS 3248 02:54:32,328 --> 02:54:36,999 DIFFERENT FROM EACH INSTITUTE. 3249 02:54:37,066 --> 02:54:41,304 WE STILL HAVE AN ACTIVE NOSI OF 3250 02:54:41,370 --> 02:54:42,605 SPECIAL INTEREST WITH SUBMISSION 3251 02:54:42,672 --> 02:54:43,840 BY JULY 2025. 3252 02:54:43,906 --> 02:54:45,174 I WOULD SAY IT'S A GREAT TIME 3253 02:54:45,241 --> 02:54:48,010 BECAUSE AFTER THIS MEETING YOU 3254 02:54:48,077 --> 02:54:49,278 WILL BETTER UNDERSTAND THE 3255 02:54:49,345 --> 02:54:52,548 POTENTIAL GAPS AND OPPORTUNITIES 3256 02:54:52,615 --> 02:54:55,518 THAT MAY PROPOSE THE INNOVATIVE 3257 02:54:55,585 --> 02:54:57,086 THING THAT WILL BE BRIDGING THE 3258 02:54:57,153 --> 02:54:59,989 THINGS THAT WERE ALREADY FUNDED 3259 02:55:00,056 --> 02:55:01,023 AND INVESTIGATED. 3260 02:55:01,090 --> 02:55:03,125 SO IF YOU THINK ABOUT POTENTIAL 3261 02:55:03,192 --> 02:55:04,594 COLLABORATION THIS WOULD BE A 3262 02:55:04,660 --> 02:55:09,332 GREAT CHANCE TO START AT IT AT 3263 02:55:09,398 --> 02:55:12,401 THE MEETING AND LET'S TALK ABOUT 3264 02:55:12,468 --> 02:55:14,537 NEXT STEPS AT THE CLINICAL OR 3265 02:55:14,604 --> 02:55:17,306 NON-CLINICAL STUDIES. 3266 02:55:17,373 --> 02:55:21,310 I KNOW GIVEN YOUR THOUGHTS MAYBE 3267 02:55:21,377 --> 02:55:24,013 RISKY BUT THIS IS THE BEST ROOM 3268 02:55:24,080 --> 02:55:25,314 BECAUSE YOU HAVE YOUR PEERS 3269 02:55:25,381 --> 02:55:29,318 DOING THE GREAT STUDIES THAT CAN 3270 02:55:29,385 --> 02:55:33,322 BETTER ADVISE YOU. 3271 02:55:33,389 --> 02:55:35,925 PLEASE GO AHEAD, YES. 3272 02:55:35,992 --> 02:55:38,594 >> ONE OF THE RUNNING PREVAILING 3273 02:55:38,661 --> 02:55:43,799 THEMES IS MYSELF INCLUDED IS 3274 02:55:43,866 --> 02:55:45,134 HARNESSING MACHINE LEARNING 3275 02:55:45,201 --> 02:55:49,305 ACROSS A VARIETY OF SPECTRA FROM 3276 02:55:49,372 --> 02:55:51,574 COMPOUND DEVELOPMENT AND TARGET 3277 02:55:51,641 --> 02:55:54,176 DISCOVERY AND BEHAVIOR. 3278 02:55:54,243 --> 02:55:56,979 POINTING TOWARDS THAT SECOND ONE 3279 02:55:57,046 --> 02:56:01,884 A BOTTLENECK FOR ME AAS A 3280 02:56:01,951 --> 02:56:05,688 TRAINED BEHAVIORALIST IS THE 3281 02:56:05,755 --> 02:56:08,824 PAIN BEHAVIOR AND DEVELOPING 3282 02:56:08,891 --> 02:56:12,728 TARGETS HOW TO TEST THAT IN AN 3283 02:56:12,795 --> 02:56:13,796 EFFICACIOUS MANNER WHEN 3284 02:56:13,863 --> 02:56:15,932 TYPICALLY WE'VE BEEN USING THE 3285 02:56:15,998 --> 02:56:20,903 MOUSE AS THE MODEL. 3286 02:56:20,970 --> 02:56:26,609 I WANTED TO HIGHLIGHT THOSE WHO 3287 02:56:26,676 --> 02:56:28,244 USE ZEBRAFISH AS A MODEL AND 3288 02:56:28,311 --> 02:56:29,712 THEY RESPOND TO PAIN AND 3289 02:56:29,779 --> 02:56:32,348 SENSITIZED PAIN AND YOU CAN 3290 02:56:32,415 --> 02:56:34,116 BREED THEM EN MASSE AND TEST 3291 02:56:34,183 --> 02:56:35,418 THEM EN MASSE. 3292 02:56:35,484 --> 02:56:36,552 THERE'S A DECENT AMOUNT OF 3293 02:56:36,619 --> 02:56:39,588 GENETIC MODELS YOU CAN GENERATE 3294 02:56:39,655 --> 02:56:41,090 WITH THEM. 3295 02:56:41,157 --> 02:56:44,093 THEY'RE EASY TO CRISPR AND 3296 02:56:44,160 --> 02:56:47,964 DEVELOP MUTANT FISH. 3297 02:56:48,030 --> 02:56:51,567 WHEN WE TALK ABOUT HIGH 3298 02:56:51,634 --> 02:56:53,936 THROUGHPUT ASSAYS IT'S DIFFICULT 3299 02:56:54,003 --> 02:56:56,138 TO THINK ABOUT PAIN BEHAVIORS. 3300 02:56:56,205 --> 02:56:58,174 THERE'S POTENTIALLY OTHER THINGS 3301 02:56:58,240 --> 02:57:00,443 TO THINK ABOUT BUT THAT WOULD BE 3302 02:57:00,509 --> 02:57:03,579 A BIG BOTTLENECK IN MY MIND 3303 02:57:03,646 --> 02:57:04,413 PRECLINICALLY IS LOOK AT THE 3304 02:57:04,480 --> 02:57:05,681 THINGS WE'RE DEVELOPING AND 3305 02:57:05,748 --> 02:57:06,349 COMING UP WITH AND DO THEY WORK 3306 02:57:06,415 --> 02:57:13,155 FOR PAIN. 3307 02:57:13,222 --> 02:57:14,256 >> THANK YOU SO MUCH. 3308 02:57:14,323 --> 02:57:24,767 IDEAS, COMMENTS, FEEDBACK? 3309 02:57:28,838 --> 02:57:31,107 >> I WAS HOPING TO GO BACK TO 3310 02:57:31,173 --> 02:57:34,377 THE VAPORIZED AND HOW MUCH DO WE 3311 02:57:34,443 --> 02:57:37,113 KNOW ABOUT OF THE METABOLISM OF 3312 02:57:37,179 --> 02:57:39,915 CANNABINOIDS WHEN GIVEN THROUGH 3313 02:57:39,982 --> 02:57:41,350 THE LUNGS WHERE THEY DON'T PASS 3314 02:57:41,417 --> 02:57:43,619 THROUGH THE LIVER VERY QUICKLY 3315 02:57:43,686 --> 02:57:45,321 VERSUS ORALLY? 3316 02:57:45,388 --> 02:57:49,325 I WONDER WHETHER THERE'S GOING 3317 02:57:49,392 --> 02:57:52,962 TO BE DIFFERENT SITUATION WITH 3318 02:57:53,029 --> 02:57:55,631 ORAL OR ENTERAL ADMINISTRATION 3319 02:57:55,698 --> 02:57:58,034 AND INHALE AND HOW THAT MIGHT 3320 02:57:58,100 --> 02:57:58,267 IMPACT. 3321 02:57:58,334 --> 02:57:59,335 >> I AGREE. 3322 02:57:59,402 --> 02:58:05,074 IT'S WORTH EXPLORING MORE IN 3323 02:58:05,141 --> 02:58:09,311 DEPTH. 3324 02:58:09,378 --> 02:58:11,380 GIVEN WHAT WE UNDERSTAND ABOUT 3325 02:58:11,447 --> 02:58:12,248 CANNABINOID USE IN THE UNITED 3326 02:58:12,314 --> 02:58:14,950 STATES WHERE MOST PEOPLE STILL 3327 02:58:15,017 --> 02:58:17,319 DO PREFER THE ORAL -- I MEAN THE 3328 02:58:17,386 --> 02:58:24,827 INHALED VERSION TYPE- 3329 02:58:24,894 --> 02:58:30,366 >> I WANTED TO ADD SOMETHING TO 3330 02:58:30,433 --> 02:58:31,467 THE VAPORIZATION. 3331 02:58:31,534 --> 02:58:36,172 THIS WAS A STUDY WHERE VITOL WAS 3332 02:58:36,238 --> 02:58:40,376 TOXIC AND WE SAW THIS THROUGH 3333 02:58:40,443 --> 02:58:43,646 INHALATION AND VITAMIN E ACETATE 3334 02:58:43,712 --> 02:58:46,182 AND ACUTE LUNG INFECTIONS 3335 02:58:46,248 --> 02:58:47,817 ASSOCIATED WITH THAT AND BECAUSE 3336 02:58:47,883 --> 02:58:49,718 THERE'S AN IDEA TERPENES ARE 3337 02:58:49,785 --> 02:58:51,754 GRASS IT'S THE SAME IF THEY'RE 3338 02:58:51,821 --> 02:58:53,322 INHALED WHERE I DON'T THINK 3339 02:58:53,389 --> 02:58:55,558 THAT'S THE CASE. 3340 02:58:55,624 --> 02:58:57,993 I THINK ZIVA WAS INTELLIGENT TO 3341 02:58:58,060 --> 02:58:58,828 USE SOMETHING TYPICALLY EXPOSED 3342 02:58:58,894 --> 02:59:03,666 BUT WE DO SEE IN THESE WHERE 3343 02:59:03,732 --> 02:59:07,703 PEOPLE ARE ADDING HIGHER LEVELS 3344 02:59:07,770 --> 02:59:08,904 OF TERPENES. 3345 02:59:08,971 --> 02:59:13,309 MAYBE FINE IN EDIBLE BUT WHEN 3346 02:59:13,375 --> 02:59:17,713 IT'S ADULTERATED IT MAY BE TOXIC 3347 02:59:17,780 --> 02:59:21,484 AND PART OF THE GOAL IS TO FIND 3348 02:59:21,550 --> 02:59:24,386 OUT ARE THESE EFFECTIVE TO TREAT 3349 02:59:24,453 --> 02:59:25,955 PAIN AND THERE'S INTERESTING 3350 02:59:26,021 --> 02:59:31,293 STUDIES BUT MY QUESTION IS AS 3351 02:59:31,360 --> 02:59:33,162 YOU TRANSITION FROM ANIMALS TO 3352 02:59:33,229 --> 02:59:35,164 HUMANS HOW DO THEY LOOK AT THEM 3353 02:59:35,231 --> 02:59:38,033 IN TERMS OF SAFETY? 3354 02:59:38,100 --> 02:59:39,702 BECAUSE THE EXPOSURE LEVEL FOUND 3355 02:59:39,768 --> 02:59:41,670 IN TYPICAL CANNABIS IS LOW. 3356 02:59:41,737 --> 02:59:43,672 IS THERE CONSIDERATION TO 3357 02:59:43,739 --> 02:59:47,977 FUNDING OR LOOKING INTO GENERAL 3358 02:59:48,043 --> 02:59:49,011 TOX STUDIES THAT WOULD SUPPORT 3359 02:59:49,078 --> 02:59:50,079 THE USE IN CLINICAL. 3360 02:59:50,146 --> 02:59:52,882 WE HAVE SOME STUDIES WITH CPG 3361 02:59:52,948 --> 02:59:54,483 NOW AND IN TOX STUDIES SUGGEST 3362 02:59:54,550 --> 02:59:58,854 YOU MAY GO TO LEVELS YOU WOULD 3363 02:59:58,921 --> 03:00:01,390 SAY THE HUNDREDS IF NOT 3364 03:00:01,457 --> 03:00:04,026 THOUSANDS OF MILLIGRAM DOSES. 3365 03:00:04,093 --> 03:00:07,696 I DON'T KNOW IF THERE'S ENOUGH 3366 03:00:07,763 --> 03:00:09,331 SUPPORTING EFFORTS TO SAY CAN WE 3367 03:00:09,398 --> 03:00:15,804 GIVE 300 OR 500 MILLIGRAMS TO 3368 03:00:15,871 --> 03:00:18,140 CBC IN CHRONIC DOSING AND IS IT 3369 03:00:18,207 --> 03:00:23,045 SAFE BECAUSE IT'S CANNABIS? 3370 03:00:23,112 --> 03:00:27,716 THAT WOULD BE GOOD START TOE SAY 3371 03:00:27,783 --> 03:00:28,684 THERE'S EVIDENCE. 3372 03:00:28,751 --> 03:00:32,154 >> THIS IS A GREAT QUESTION. 3373 03:00:32,221 --> 03:00:34,690 AND WE DO ALLOW THE COMPONENT 3374 03:00:34,757 --> 03:00:38,694 FOR THE TEXAS IN THE STUDY THAT 3375 03:00:38,761 --> 03:00:40,162 WOULD BE MAINLY FOCUSSED ON 3376 03:00:40,229 --> 03:00:41,063 THERAPEUTIC POTENTIAL. 3377 03:00:41,130 --> 03:00:47,670 YOU CAN HAVE BOTH. 3378 03:00:47,736 --> 03:00:52,174 ALSO THE REASON FOR POTENTIAL 3379 03:00:52,241 --> 03:00:56,679 TOXICITY OR ADVERSE AFFECTS AND 3380 03:00:56,745 --> 03:00:59,215 IF IT'S MOSTLY FOR ANALGESIC 3381 03:00:59,281 --> 03:01:02,251 POTENTIAL THAT WOULD BE ALIGNING 3382 03:01:02,318 --> 03:01:03,786 BETTER WITH THE END STABLE IF 3383 03:01:03,852 --> 03:01:05,621 THE MAIN FOCUS IS ON THE TOX 3384 03:01:05,688 --> 03:01:09,325 STUDY THAT WOULD POTENTIALLY GO 3385 03:01:09,391 --> 03:01:19,068 TO NIDA. 3386 03:01:19,134 --> 03:01:22,171 >> THE COMPUTATIONAL PREDICTIONS 3387 03:01:22,238 --> 03:01:24,173 ARE BASICALLY A FANTASY WORLD 3388 03:01:24,240 --> 03:01:25,874 UNTIL IT'S TESTED. 3389 03:01:25,941 --> 03:01:27,810 AND THE WE'RE TESTING THE 3390 03:01:27,876 --> 03:01:29,411 COMPOUNDS AND GETTING THE 3391 03:01:29,478 --> 03:01:31,580 INFORMATION AND GOING BACK AND 3392 03:01:31,647 --> 03:01:35,351 FORTH IT'S IN A SENSE USELESS. 3393 03:01:35,417 --> 03:01:37,319 COMPUTATION GENERATES SOME 3394 03:01:37,386 --> 03:01:38,821 HYPOTHESIS AND SO I THINK IT'S 3395 03:01:38,887 --> 03:01:44,426 AN INCREDIBLE RESEARCH BECAUSE 3396 03:01:44,493 --> 03:01:47,096 IF YOU HAVE A GAZILLION 3397 03:01:47,162 --> 03:01:49,765 COMPOUNDS AND PRIORITIZE THE 3398 03:01:49,832 --> 03:01:51,333 COMBINATIONS IT COULD BE A HUGE 3399 03:01:51,400 --> 03:01:51,600 RESOURCE. 3400 03:01:51,667 --> 03:01:54,236 ONE THING THAT COULD BE REALLY 3401 03:01:54,303 --> 03:01:56,805 HELPFUL AND HAS BEEN HELPFUL IN 3402 03:01:56,872 --> 03:01:57,573 OTHER FIELD LIKE PROTEIN 3403 03:01:57,640 --> 03:02:01,310 DATABASE CREATED AND WAS A HUGE 3404 03:02:01,377 --> 03:02:04,179 RESOURCE IN THE G BANK AND 3405 03:02:04,246 --> 03:02:06,915 INTEGRATED RESOURCE OF GROSS AL 3406 03:02:06,982 --> 03:02:08,417 DATA AND COMPUTATIONAL DATA THAT 3407 03:02:08,484 --> 03:02:18,527 CAN PLAY OFF EACH OTHER. 3408 03:02:18,594 --> 03:02:25,334 AND WE CAN ENHANCE THE SPACE OF 3409 03:02:25,401 --> 03:02:26,869 COMPOUNDS PARTICULARLY RECEPTORS 3410 03:02:26,935 --> 03:02:31,573 THROUGH TOOLS THAT HAVE BEEN 3411 03:02:31,640 --> 03:02:33,309 RECENTLY DEVELOPED THAT HAVE 3412 03:02:33,375 --> 03:02:34,610 SCREENINGS OF BILLIONS OF 3413 03:02:34,677 --> 03:02:36,912 COMPOUNDS A DAY AND IF YOU'RE 3414 03:02:36,979 --> 03:02:37,680 LOOKING FOR NEW CANNABINOIDS 3415 03:02:37,746 --> 03:02:39,615 IT'S NOT HARD TO DO BUT YOU 3416 03:02:39,682 --> 03:02:44,787 GENERATE A LIST OF MANY 3417 03:02:44,853 --> 03:02:46,722 COMPOUNDS THAT WE NEED TO SCREEN 3418 03:02:46,789 --> 03:02:49,325 AND A GOOD WAY TO MOVE FORWARD 3419 03:02:49,391 --> 03:02:53,329 TO TRANSLATION IS TO CREATE A 3420 03:02:53,395 --> 03:02:55,497 GENERAL RESOURCE THAT WILL 3421 03:02:55,564 --> 03:02:56,999 COMBINE EXPERIMENTAL AND 3422 03:02:57,066 --> 03:02:57,966 COMPUTATIONAL DATA AND BRING 3423 03:02:58,033 --> 03:02:58,434 COMMUNITIES TOGETHER. 3424 03:02:58,500 --> 03:03:06,442 >> GREAT SUGGESTION. 3425 03:03:06,508 --> 03:03:10,179 >> THERE'S A NEW POLICY THAT WAS 3426 03:03:10,245 --> 03:03:11,413 WHAT IT WAS SUPPOSED TO DO AND 3427 03:03:11,480 --> 03:03:12,781 THE CHALLENGE IS NO ONE CAN 3428 03:03:12,848 --> 03:03:15,517 AGREE WHERE TO PUT THE DATA. 3429 03:03:15,584 --> 03:03:17,786 ALL YOU OF YOU IN THE FIELD MAY 3430 03:03:17,853 --> 03:03:21,256 BE SHARING DATA BUT I GUARANTEE 3431 03:03:21,323 --> 03:03:23,759 YOUR NOT STORING IN THE SAME 3432 03:03:23,826 --> 03:03:26,428 PRAISE BUT THERE'S EXISTING 3433 03:03:26,495 --> 03:03:28,530 REPOSITORIES IF YOU CAN AGREE 3434 03:03:28,597 --> 03:03:33,302 WHICH TO PUT IT IN YOUR PROBLEM 3435 03:03:33,369 --> 03:03:36,438 WOULD BE SOLVED BUT NO ONE CAN 3436 03:03:36,505 --> 03:03:42,010 AGREE WHAT TO HAVE FOR LUNCH LET 3437 03:03:42,077 --> 03:03:43,379 ALONE WHERE TO PUT THEIR DATA 3438 03:03:43,445 --> 03:03:45,347 AND THEY CREATED THE DATA 3439 03:03:45,414 --> 03:03:47,383 MANAGEMENT SHARING POLICY WITH 3440 03:03:47,449 --> 03:03:52,154 THE HOPE THERE WOULD BE MORE 3441 03:03:52,221 --> 03:03:52,921 DATA CONGREGATING IN THE SAME 3442 03:03:52,988 --> 03:03:53,322 PLACE. 3443 03:03:53,389 --> 03:03:55,691 WE SEE HOW WELL IT PLAYS OUT. 3444 03:03:55,758 --> 03:04:06,168 >> THANK YOU, DR. HOFF. 3445 03:04:08,904 --> 03:04:13,942 ALSO TODAY THERE WILL BE A 3446 03:04:14,009 --> 03:04:14,977 SPECIAL PRESENTATION FROM THE 3447 03:04:15,043 --> 03:04:24,086 COLLEAGUE ABOUT THE NCCIH 3448 03:04:24,153 --> 03:04:24,787 RESOURCE CENTER INITIATIVE. 3449 03:04:24,853 --> 03:04:27,856 THESE ARE INTERESTING 3450 03:04:27,923 --> 03:04:33,395 SUGGESTIONS AND VERY HELPFUL FOR 3451 03:04:33,462 --> 03:04:37,299 NEXT DIRECTIONS. 3452 03:04:37,366 --> 03:04:41,303 ANY OTHER THOUGHTS ON 3453 03:04:41,370 --> 03:04:47,342 NON-CLINICAL? 3454 03:04:47,409 --> 03:04:49,044 SFWR I 3455 03:04:50,846 --> 03:04:56,885 >> I WANT TO ECHO WHAT DR. HARTE 3456 03:04:56,952 --> 03:04:58,954 AND I WOULD LOVE IF EVERYONE 3457 03:04:59,021 --> 03:05:00,189 ACCEPTS THE METHODS MY LAB DOES 3458 03:05:00,255 --> 03:05:10,165 AND I SOO -- SEE THE MACHINE 3459 03:05:10,232 --> 03:05:11,834 LEARNING AND THEY SAY USE THIS 3460 03:05:11,900 --> 03:05:15,003 AND IT'S NOT EASY AND IT'S 3461 03:05:15,070 --> 03:05:17,039 CHANGING AND THE SOFTWARE'S 3462 03:05:17,105 --> 03:05:17,306 CHANGING. 3463 03:05:17,372 --> 03:05:20,209 EVEN IF WE WERE TO AGREE ON WHAT 3464 03:05:20,275 --> 03:05:21,877 FACTORS WE WANT THE BLACK BOX TO 3465 03:05:21,944 --> 03:05:24,179 OUTPUT FOR US WHICH IS LIMITED, 3466 03:05:24,246 --> 03:05:25,647 IT'S ALSO CHANGING AS WE'RE 3467 03:05:25,714 --> 03:05:26,482 USING IT. 3468 03:05:26,548 --> 03:05:27,683 THOSE ARE OTHER TYPES OF THINGS 3469 03:05:27,749 --> 03:05:30,385 WE'LL NEED TO THINK ABOUT AND 3470 03:05:30,452 --> 03:05:31,753 TRYING TO PUSH FOR CONSISTENCY 3471 03:05:31,820 --> 03:05:33,489 HERE AND MAKE HELPFUL 3472 03:05:33,555 --> 03:05:35,157 SUGGESTIONS AS WE'RE REVIEWING 3473 03:05:35,224 --> 03:05:37,326 EACH OTHER'S WORK BECAUSE I'M 3474 03:05:37,392 --> 03:05:40,195 NOT SURE HOW THE BEHAVIORAL 3475 03:05:40,262 --> 03:05:49,304 ASSAYS WILL CHANGE OVER TIME. 3476 03:05:49,371 --> 03:05:52,174 >> I'M GOING TO JUMP IN AGAIN 3477 03:05:52,241 --> 03:06:00,816 WITH A THOUGHT QUESTION NOT TO 3478 03:06:00,883 --> 03:06:03,919 PERSERVERATE BUT GOING TO THE 3479 03:06:03,986 --> 03:06:05,988 CLINICAL TRIALS AND FROM A 3480 03:06:06,054 --> 03:06:09,324 CLINICAL CLINICIAN VIEW POINT. 3481 03:06:09,391 --> 03:06:19,868 I THINK WE'D BE REMISS AND 3482 03:06:20,202 --> 03:06:25,707 PEOPLE TALK TOPICAL PRODUCTS AND 3483 03:06:25,774 --> 03:06:28,977 I HAVEN'T HEARD RESEARCH ON 3484 03:06:29,044 --> 03:06:34,016 TOPICAL VERSIONS IN TERMS OF 3485 03:06:34,082 --> 03:06:37,319 ROOT OF ADMINISTRATION AND 3486 03:06:37,386 --> 03:06:45,561 CURIOUS AND PEOPLE RUB THINGS IN 3487 03:06:45,627 --> 03:06:48,897 TO THEIR SKIN IN ADDITION TO 3488 03:06:48,964 --> 03:06:49,131 ORALLY. 3489 03:06:49,197 --> 03:06:50,632 HAS ANYONE HERE THOUGHT ABOUT 3490 03:06:50,699 --> 03:06:56,004 STUDYING TOPICALLY ADMINISTERED 3491 03:06:56,071 --> 03:06:57,239 CANNABINOIDS OR CANNABIS 3492 03:06:57,306 --> 03:06:59,041 PRODUCTS OR IS THAT SOMETHING 3493 03:06:59,107 --> 03:07:04,046 THAT AGAIN IS TOO MESSY TO DO A 3494 03:07:04,112 --> 03:07:09,318 REALLY GOOD CLINICAL TRIAL OR 3495 03:07:09,384 --> 03:07:09,751 NON-CLINICAL TRIAL? 3496 03:07:09,818 --> 03:07:14,690 PLEASE. 3497 03:07:14,756 --> 03:07:15,657 IS 3498 03:07:15,724 --> 03:07:19,061 >> WE'VE BEEN USING IN 3499 03:07:19,127 --> 03:07:21,296 OSTEOARTHRITIS IN MICE AND 3500 03:07:21,363 --> 03:07:22,998 FRACTURING HEALING IN RODENTS. 3501 03:07:23,065 --> 03:07:26,234 I THINK IT'S A REMARKABLY RICH 3502 03:07:26,301 --> 03:07:31,740 AREA TO EXPLORE AND TELL ONE 3503 03:07:31,807 --> 03:07:36,979 STO 3504 03:07:37,045 --> 03:07:39,114 STORY FOLKS THAT WENT TO OUR 3505 03:07:39,181 --> 03:07:40,849 MEDICAL PROGRAM IN PENNSYLVANIA 3506 03:07:40,916 --> 03:07:42,351 WOULD COME INTO THE CLINICAL 3507 03:07:42,417 --> 03:07:47,923 RESEARCH CENTER AND WE WOULD ASK 3508 03:07:47,990 --> 03:07:51,326 A SIMPLE QUESTION HOW MUCH 3509 03:07:51,393 --> 03:07:53,061 TOPICAL GETS IN THE CIRCULATION 3510 03:07:53,128 --> 03:07:55,964 AND WILL I FAIL A DRUG TEST AND 3511 03:07:56,031 --> 03:07:57,699 MY IRB BOUGHT IT AND THE FDA 3512 03:07:57,766 --> 03:08:01,336 SAID I NEEDED INVESTIGATIONAL 3513 03:08:01,403 --> 03:08:07,275 NEW DRUG APPLICATION. 3514 03:08:07,342 --> 03:08:09,211 RESCHEDULING SHOULD HELP BUT 3515 03:08:09,277 --> 03:08:11,546 GIVEN THE FELICITY OF THE 3516 03:08:11,613 --> 03:08:13,315 MOLECULES THEY'LL BE USING FOR 3517 03:08:13,382 --> 03:08:15,150 IN A TOPICAL FORM. 3518 03:08:15,217 --> 03:08:19,588 AS LONG AS I WANTED THE MIC IF I 3519 03:08:19,655 --> 03:08:22,624 CAN CHANGE THE SUBJECT FOR A 3520 03:08:22,691 --> 03:08:25,527 SECOND, ONE THING WE'RE IGNORING 3521 03:08:25,594 --> 03:08:31,667 IS PHARMACO GENOMICS AND THE THC 3522 03:08:31,733 --> 03:08:34,202 IN THE PLANT REACHED THE UPPER 3523 03:08:34,269 --> 03:08:37,839 LIMIT 30% TO 35% BY WEIGHT WE'RE 3524 03:08:37,906 --> 03:08:43,245 SEEING THE SIDE EFFECTS AND 3525 03:08:43,311 --> 03:08:45,280 ACUTE PSYCHOSIS AND CANNABIS 3526 03:08:45,347 --> 03:08:48,817 SYNDROME AND THESE DRUGS ARE 3527 03:08:48,884 --> 03:08:53,155 METABOLIZED BY 2C9 AND 3A4 AND 3528 03:08:53,221 --> 03:08:56,792 FOR 3A4 THERE'S FOUR ALLELES 3529 03:08:56,858 --> 03:08:59,861 THAT COMPRISE THE ACTIVITY AND 3530 03:08:59,928 --> 03:09:05,300 HAVE ULTRA METABOLIZERS AND 3531 03:09:05,367 --> 03:09:07,436 NON-METABOLIZERS AND WE HAVE NO 3532 03:09:07,502 --> 03:09:07,636 IDEA. 3533 03:09:07,703 --> 03:09:09,805 IT WILL ADD ANOTHER DIMENSION TO 3534 03:09:09,871 --> 03:09:12,607 THE BIG DATA OF THE GENOTYPES OF 3535 03:09:12,674 --> 03:09:15,343 OUR SUBJECTS AND HOW DOES THAT 3536 03:09:15,410 --> 03:09:16,678 INFLUENCE HOW THEY'LL RESPOND 3537 03:09:16,745 --> 03:09:19,981 AND WHETHER THEY'LL HAVE SIDE 3538 03:09:20,048 --> 03:09:20,215 EFFECTS. 3539 03:09:20,282 --> 03:09:22,117 DOES IT WORK FOR THEM IF THEY'RE 3540 03:09:22,184 --> 03:09:25,987 AN ULTRA METABOLIZER OR DO THEY 3541 03:09:26,054 --> 03:09:31,059 HAVE SIDE EFFECTS BECAUSE OF 3542 03:09:31,126 --> 03:09:32,861 COMPRISED EFFECTS. 3543 03:09:32,928 --> 03:09:37,132 THIS GOES TO THE COMPLEXITIES OF 3544 03:09:37,199 --> 03:09:37,966 THE CLINICAL TRIALS. 3545 03:09:38,033 --> 03:09:40,569 ON THE OTHER HAND, THINKING 3546 03:09:40,635 --> 03:09:44,072 ABOUT THERAPEUTIC BIOMARKERS, 3547 03:09:44,139 --> 03:09:47,542 THINKING ABOUT HOW TO PREDICT 3548 03:09:47,609 --> 03:09:50,846 WHO WILL BE RESPONDING BETTER 3549 03:09:50,912 --> 03:09:53,715 PROBABLY FOR THE INDIVIDUALIZED 3550 03:09:53,782 --> 03:09:58,253 APPROACH GENETICS AND PHARMACO 3551 03:09:58,320 --> 03:10:01,323 GENOMICS WOULD BE ESSENTIAL WILL 3552 03:10:01,389 --> 03:10:11,399 STEPS IN CLINICAL TRIALS. 3553 03:10:11,466 --> 03:10:14,336 >> AS I LISTEN TO THE BASIC 3554 03:10:14,402 --> 03:10:21,176 STUDIES WITH ELEGANT HABIT -- 3555 03:10:21,243 --> 03:10:22,210 LABORATORY METHODS I'M CURIOUS 3556 03:10:22,277 --> 03:10:25,313 ABOUT THE TRANSLATIONAL 3557 03:10:25,380 --> 03:10:26,515 QUESTION. 3558 03:10:26,581 --> 03:10:32,954 IT SEEMS THE STUDIES USED 3559 03:10:33,021 --> 03:10:33,688 SYNTHETIC CANNABINOIDS AND 3560 03:10:33,755 --> 03:10:35,090 THAT'S NOT WHAT OUR PARTICIPANTS 3561 03:10:35,157 --> 03:10:39,494 BUY AT DISPENSARIES AND DO WE 3562 03:10:39,561 --> 03:10:40,962 HAVE GOOD EVIDENCE THE 3563 03:10:41,029 --> 03:10:43,732 SYNTHETICS WORK THE SAME WAY IN 3564 03:10:43,799 --> 03:10:49,304 TERMS OF PHARMACO DYNAMICS AND 3565 03:10:49,371 --> 03:10:52,240 WHETHER THEY IMPACT SYMPTOMS 3566 03:10:52,307 --> 03:10:53,308 WHETHER SYNTHETIC OR NATURAL 3567 03:10:53,375 --> 03:10:53,975 VERSIONS AND DOSE. 3568 03:10:54,042 --> 03:10:56,478 I LOOK AT SOME OF THE DOSES IN 3569 03:10:56,545 --> 03:10:57,345 THE DIFFERENCE STUDIES AND THEY 3570 03:10:57,412 --> 03:10:59,314 SEEM TO BE ALL OVER THE PLACE. 3571 03:10:59,381 --> 03:11:01,917 AND VERY DIFFERENT FOR ANIMAL 3572 03:11:01,983 --> 03:11:03,618 MODELS VERSUS HUMANS, LOW DOSES 3573 03:11:03,685 --> 03:11:06,855 IN SOME STUDIES, SUPER HIGH IN 3574 03:11:06,922 --> 03:11:07,088 OTHERS. 3575 03:11:07,155 --> 03:11:12,027 THAT'S ANOTHER QUESTION IS HOW 3576 03:11:12,093 --> 03:11:22,270 DO WE FIGURE OUT IN TERPENES AND 3577 03:11:22,337 --> 03:11:32,848 WHAT CLINICAL DOSES SHOULD BE. 3578 03:12:08,016 --> 03:12:11,686 >> I OFTEN WISH THERE WAS A 3579 03:12:11,753 --> 03:12:22,297 DATABASE AND A MOUSE IS MY MAGIC 3580 03:12:25,066 --> 03:12:25,500 CBD DOSE AND THAT THE AN 3581 03:12:25,567 --> 03:12:26,167 EXCELLENT POINT. 3582 03:12:26,234 --> 03:12:27,636 I DON'T KNOW THE BIG DIFFERENCE 3583 03:12:27,702 --> 03:12:33,108 IN OUR WORK IS THE PRE CLINICAL 3584 03:12:33,174 --> 03:12:36,077 FOLKS ARE USING SYNTHETIC VERSUS 3585 03:12:36,144 --> 03:12:37,279 A CRYSTALLIZED POWDER 3586 03:12:37,345 --> 03:12:41,016 FORMULATION WE CAN THEN MAKE UP 3587 03:12:41,082 --> 03:12:44,519 IN DIFFERENT CONCENTRATIONS AND 3588 03:12:44,586 --> 03:12:45,186 ADMINISTER. 3589 03:12:45,253 --> 03:12:49,724 I THINK THAT'S THE BIGGER 3590 03:12:49,791 --> 03:12:50,959 DIFFERENCE RATHER THAN SYNTHETIC 3591 03:12:51,026 --> 03:12:52,294 THAT WE'RE NOT USING EXTRACTS, 3592 03:12:52,360 --> 03:13:02,570 FOR EXAMPLE. 3593 03:13:05,440 --> 03:13:08,944 >> I'M SAYING THIS FROM THE 3594 03:13:09,010 --> 03:13:11,446 PERSPECTIVE OF HAVING DONE WORK 3595 03:13:11,513 --> 03:13:13,081 ON THE FOOTBALL TEAM AT TO THE 3596 03:13:13,148 --> 03:13:14,482 UNIVERSITY OF UTAH WHO NEVER 3597 03:13:14,549 --> 03:13:18,553 HAVE PAIN AND SOME ARE VETERANS 3598 03:13:18,620 --> 03:13:21,423 AND HAVE EXPOSURE TO PTSD AND 3599 03:13:21,489 --> 03:13:23,158 CHRONIC PAIN AND SOME OF THE 3600 03:13:23,224 --> 03:13:25,360 NEWER WORK ONE OF MY COLLEAGUES 3601 03:13:25,427 --> 03:13:28,330 WHO IS HERE IS ESTABLISHING WITH 3602 03:13:28,396 --> 03:13:30,732 THE NATIVE AMERICAN POPULATION. 3603 03:13:30,799 --> 03:13:32,968 INDIGENOUS POPULATIONS AND HOW 3604 03:13:33,034 --> 03:13:34,736 IMPORTANT CULTURE IS FOR 3605 03:13:34,803 --> 03:13:36,104 ASSESSING PAIN AND LIFE 3606 03:13:36,171 --> 03:13:38,807 EXPERIENCE IN TERMS OF PAIN 3607 03:13:38,873 --> 03:13:42,711 TOLERANCE GOALS. 3608 03:13:42,777 --> 03:13:45,914 AND AGAIN I AGREE WITH THE 3609 03:13:45,981 --> 03:13:50,285 COMMENTS PRESENTED TODAY BUT WE 3610 03:13:50,352 --> 03:13:56,057 WEEN TO THE NECESSARY AGREE IN 3611 03:13:56,124 --> 03:13:56,558 STUD 3612 03:13:56,624 --> 03:13:56,791 STUDIES. 3613 03:13:56,858 --> 03:14:07,102 >> THANK YOU. 3614 03:14:11,039 --> 03:14:12,440 >> THERE'S A CANNABIS HEALTH 3615 03:14:12,507 --> 03:14:13,942 RESEARCH INITIATIVE AND TIME TO 3616 03:14:14,009 --> 03:14:16,044 GET AT A COUPLE THINGS YOU 3617 03:14:16,111 --> 03:14:17,312 TALKED ABOUT AS FAR AS PUTTING 3618 03:14:17,379 --> 03:14:18,013 INFORMATION TOGETHER TO WE'RE 3619 03:14:18,079 --> 03:14:19,514 LEARNING FROM EACH OTHER BECAUSE 3620 03:14:19,581 --> 03:14:20,548 WE HAVE DIFFERENT PEOPLE DOING 3621 03:14:20,615 --> 03:14:21,216 DIFFERENT THINGS AND THE ONLY 3622 03:14:21,282 --> 03:14:24,986 WAY THEY HAVE THE ABILITY TO DO 3623 03:14:25,053 --> 03:14:30,291 THEM IS WE REALIZE IS VERY 3624 03:14:30,358 --> 03:14:31,726 DIFFICULT AND SO ONE OF THE 3625 03:14:31,793 --> 03:14:34,095 PURPOSES OF THE PROJECT THAT 3626 03:14:34,162 --> 03:14:37,332 JUST CAME ONLINE THROUGH JOHNS 3627 03:14:37,399 --> 03:14:41,803 HOPKINS IS THEY'RE HOPING TO 3628 03:14:41,870 --> 03:14:45,940 GATHER PATIENT-CENTERED 3629 03:14:46,007 --> 03:14:47,776 INFORMATION USEFUL FOR THOSE IN 3630 03:14:47,842 --> 03:14:49,310 A CLINICAL CENTER TO LEARN FROM 3631 03:14:49,377 --> 03:14:51,579 EACH OTHER THIS IS THE DATA 3632 03:14:51,646 --> 03:14:56,818 WE'VE BEEN COLLECTING IN OUR 3633 03:14:56,885 --> 03:14:59,054 CLINICAL POPULATION AND HAVE IT 3634 03:14:59,120 --> 03:15:02,524 IN ONE PLACE TO BE DISSEMINATED 3635 03:15:02,590 --> 03:15:04,092 AND THE DATA COLLECTION HAS 3636 03:15:04,159 --> 03:15:06,528 DIFFERENT PARTS BUT URGE THOSE 3637 03:15:06,594 --> 03:15:07,629 INTERESTED IN THE 3638 03:15:07,695 --> 03:15:08,329 PATIENT-FOCUSSED SIDE OF THINGS 3639 03:15:08,396 --> 03:15:10,298 TO TAKE A LOOK AND IF YOU NEED 3640 03:15:10,365 --> 03:15:12,167 HELP FINDING IT, I'M MARCIA. 3641 03:15:12,233 --> 03:15:13,301 SEEK ME OUT AND I'LL HELP YOU 3642 03:15:13,368 --> 03:15:13,768 FIND IT. 3643 03:15:13,835 --> 03:15:23,511 >> THANK YOU SO MUCH, MARCIA. 3644 03:15:23,578 --> 03:15:26,614 >> WE MAY HAVE TIME FOR ONE 3645 03:15:26,681 --> 03:15:28,049 QUESTION BEFORE THE LUNCH. 3646 03:15:28,116 --> 03:15:30,852 YOUR CHANCE FOR ONE QUESTION, IF 3647 03:15:30,919 --> 03:15:33,154 NOT, WE CAN HAVE THIS MINUTE 3648 03:15:33,221 --> 03:15:36,891 ADDED TO THE LUNCH BREAK. 3649 03:15:36,958 --> 03:15:40,762 SO THAT WAS AN ABSOLUTELY 3650 03:15:40,829 --> 03:15:44,432 PHENOMENAL PART OF THE DAY 21 3651 03:15:44,499 --> 03:15:44,766 PRESENTATIONS. 3652 03:15:44,833 --> 03:15:47,202 WONDERFUL DATA. 3653 03:15:47,268 --> 03:15:49,304 AND GREAT IDEA SO WE CAN 3654 03:15:49,370 --> 03:15:52,807 CONTINUE DISCUSSING IT OVER THE 3655 03:15:52,874 --> 03:16:00,482 LUNCH LUX WILL BE NETWORKING AND 3656 03:16:00,548 --> 03:16:02,117 IT WILL BE OPEN IN TWO MINUTES 3657 03:16:02,183 --> 03:16:03,418 AND YOU'RE WELCOME TO GO THERE 3658 03:16:03,485 --> 03:16:08,957 AND WE ENCOURAGE YOU TO START 3659 03:16:09,023 --> 03:16:10,492 THE CONVERSATION ABOUT POTENTIAL 3660 03:16:10,558 --> 03:16:11,659 COLLABORATIONS AND BRINGING 3661 03:16:11,726 --> 03:16:13,094 EXPERTISE TO POTENTIAL 3662 03:16:13,161 --> 03:16:15,997 APPLICATIONS TO NIH. 3663 03:16:16,064 --> 03:16:16,598 THANK YOU VERY MUCH FOR THE 3664 03:16:16,664 --> 03:16:19,667 GREAT HALF OF THE DAY AND WE'LL 3665 03:16:19,734 --> 03:16:21,302 SEE YOU BACK AT 1:30 SHARP. 3666 03:16:21,369 --> 03:16:27,775 THANK YOU. 3667 03:16:27,842 --> 03:17:10,318 WELCOME TO DR. PIOMELLI AFTER 3668 03:17:10,385 --> 03:17:12,787 WORKING AT THE NEURO SCIENCE 3669 03:17:12,854 --> 03:17:20,161 INSTITUTE IN SAN DIEGO AND 3670 03:17:20,228 --> 03:17:25,767 JOINED THE UNIVERSITY OF IRVINE 3671 03:17:25,833 --> 03:17:28,102 THE CHAIR IN NEURO SCIENTISTS 3672 03:17:28,169 --> 03:17:31,039 AND PHARMACOLOGY AND BIOLOGICAL 3673 03:17:31,105 --> 03:17:31,306 CHEMISTRY. 3674 03:17:31,372 --> 03:17:34,609 DR. PIOMELLI IS THE AUTHOR OF 3675 03:17:34,676 --> 03:17:41,382 OVER 450 PEER-REVIEWED ARTICLES 3676 03:17:41,449 --> 03:17:42,550 IN NATURE OF NEUROSCIENCE AND 3677 03:17:42,617 --> 03:17:46,154 HAS TWO FULL-LENGTH BOOKS AND 34 3678 03:17:46,221 --> 03:17:46,387 PATENTS. 3679 03:17:46,454 --> 03:17:49,390 HIS RESEARCH IS FOCUSSED ON 3680 03:17:49,457 --> 03:17:50,825 UNDERSTANDING HOW 3681 03:17:50,892 --> 03:17:51,459 ENDOCANNABINOID SUBSTANCES AND 3682 03:17:51,526 --> 03:17:54,429 OTHER LIPID SINGLING MOLECULES 3683 03:17:54,495 --> 03:17:55,463 AFFECT THE FUNCTION OF THE BRAIN 3684 03:17:55,530 --> 03:17:59,334 AND ALERT ORGANS AND 3685 03:17:59,400 --> 03:18:01,035 INVESTIGATED BIO CHEMICAL 3686 03:18:01,102 --> 03:18:01,736 PATHWAYS INVOLVED IN THE 3687 03:18:01,803 --> 03:18:05,373 FORMATION AND DEACTIVATION OF 3688 03:18:05,440 --> 03:18:08,209 ENDOCANNABINOID TRANSMITTERS AND 3689 03:18:08,276 --> 03:18:11,713 UNCOVERED ROLES PLAYED IN THE 3690 03:18:11,779 --> 03:18:12,880 MOLECULES AND WELL PROVIDE AN 3691 03:18:12,947 --> 03:18:16,084 OVERVIEW OF SAFETY AND EFFICACY 3692 03:18:16,150 --> 03:18:23,157 OF CANNABIS BASED STRATEGIES IN 3693 03:18:23,224 --> 03:18:27,629 ANIMAL MODELS AND HUMAN-BASED 3694 03:18:27,695 --> 03:18:27,929 STUDIES. 3695 03:18:27,996 --> 03:18:28,863 >> THANK YOU FOR THE KIND 3696 03:18:28,930 --> 03:18:39,474 INTRODUCTION AND FOR HAVING ME. 3697 03:18:41,776 --> 03:18:45,613 >> THE TOPIC IS AS I'M SURE YOU 3698 03:18:45,680 --> 03:18:47,982 REALIZE VERY LARGE, TOO LARGE 3699 03:18:48,049 --> 03:18:50,385 FOR A 30, 35 MINUTE PRESENTATION 3700 03:18:50,451 --> 03:18:53,154 AND WHAT I THOUGHT I'D DO 3701 03:18:53,221 --> 03:18:55,990 INSTEAD IS FOCUS ON TWO 3702 03:18:56,057 --> 03:19:02,263 PARTICULAR SUB TOPICS OR POINTS. 3703 03:19:02,330 --> 03:19:06,334 ONE IS TO DEVELOP METHODOLOGICAL 3704 03:19:06,401 --> 03:19:08,303 ISSUES REGARDING CANNABIS 3705 03:19:08,369 --> 03:19:10,071 RESEARCH AND BIAS, CAUSALITY AND 3706 03:19:10,138 --> 03:19:13,374 CONFOUNDERS AND THE OTHER IS TO 3707 03:19:13,441 --> 03:19:15,943 PRESENT EXAMPLES OF THIS 3708 03:19:16,010 --> 03:19:18,112 METHODOLOGICAL ISSUES TO CASE 3709 03:19:18,179 --> 03:19:18,479 STUDIES. 3710 03:19:18,546 --> 03:19:23,217 ONE CANNABIS IN PSYCHOSIS AND 3711 03:19:23,284 --> 03:19:26,187 THE OTHER CANNABIS AS AN 3712 03:19:26,254 --> 03:19:26,454 ANALGESIC. 3713 03:19:26,521 --> 03:19:27,488 LET'S LOOK AT THE METHODOLOGICAL 3714 03:19:27,555 --> 03:19:28,156 ISSUES FIRST. 3715 03:19:28,222 --> 03:19:29,691 WHEN I SPEAK OF BIAS IN THIS 3716 03:19:29,757 --> 03:19:32,694 CASE I DO NOT MEAN GENDER BIAS 3717 03:19:32,760 --> 03:19:33,695 OR RACE BIAS. 3718 03:19:33,761 --> 03:19:37,699 I MEAN SOMETHING THAT IS 3719 03:19:37,765 --> 03:19:41,035 ACTUALLY AS PERNICIOUS BUT MORE 3720 03:19:41,102 --> 03:19:42,837 INSIDIOUS AND WOULD LIKE TO GO 3721 03:19:42,904 --> 03:19:45,707 OVER WITH YOU IN A MINUTE AND 3722 03:19:45,773 --> 03:19:49,944 TALK ABOUT CAUSALITY AND WHAT 3723 03:19:50,011 --> 03:19:56,718 ISSUES PRESENT WITH CANNABIS AND 3724 03:19:56,784 --> 03:19:57,018 CONFOUNDERS. 3725 03:19:57,085 --> 03:19:59,487 AND ALL OF US RECOGNIZE IT'S A 3726 03:19:59,554 --> 03:20:04,492 VERY DICHOTOMOUS DEBATE AND 3727 03:20:04,559 --> 03:20:05,126 POLARIZED DEBATE. 3728 03:20:05,193 --> 03:20:11,366 YOU CAN HEAR OPINIONS THAT RANGE 3729 03:20:11,432 --> 03:20:17,372 FROM CANNABIS AS ONE OF THE MOST 3730 03:20:17,438 --> 03:20:20,274 TOXIC SUBSTANCES ON THE PLANET 3731 03:20:20,341 --> 03:20:24,212 EXEMPLAIFIED BY THE CAMPAIGN JUT 3732 03:20:24,278 --> 03:20:28,750 SAY NO TO DRUGS AND WE HAVE THE 3733 03:20:28,816 --> 03:20:31,185 OPPOSITE SIDE AND FOLKS WHO 3734 03:20:31,252 --> 03:20:33,521 BELIEVE CANNABIS IS BASICALLY A 3735 03:20:33,588 --> 03:20:37,992 CURE-ALL AND PANACEA FOR ALL 3736 03:20:38,059 --> 03:20:40,228 POSSIBLE AILMENTS. 3737 03:20:40,294 --> 03:20:44,065 AND OF COURSE THE PROBLEM IS WE 3738 03:20:44,132 --> 03:20:45,767 SCIENTISTS ARE SITTING RIGHT IN 3739 03:20:45,833 --> 03:20:48,403 THE MIDDLE OF THIS AND SO WE'RE 3740 03:20:48,469 --> 03:20:49,036 LITERALLY BETWEEN A ROCK AND A 3741 03:20:49,103 --> 03:20:52,540 HARD PLACE. 3742 03:20:52,607 --> 03:20:58,946 NOW, THIS IS NOT JUST AWKWARD, 3743 03:20:59,013 --> 03:21:03,918 IT'S ALSO PROBLEMATE IC US BECAE 3744 03:21:03,985 --> 03:21:05,820 US UNDERSTANDING THAT. 3745 03:21:05,887 --> 03:21:10,158 THAT DICHOTOMY IS ALSO LARGELY 3746 03:21:10,224 --> 03:21:12,293 UNIQUE TO CANNABIS AND IT HAS 3747 03:21:12,360 --> 03:21:14,962 ALSO VERY DEEP ROOTS AND THE 3748 03:21:15,029 --> 03:21:20,301 CONSEQUENCES ARE THOSE THAT I'M 3749 03:21:20,368 --> 03:21:21,836 WORRIED ABOUT. 3750 03:21:21,903 --> 03:21:23,671 THIS IS AN AUDIENCE OF 3751 03:21:23,738 --> 03:21:28,142 PHARMACOLOGISTS AND SCIENTISTS 3752 03:21:28,209 --> 03:21:30,978 AND YOU ALL KNOW THERE'S 3753 03:21:31,045 --> 03:21:35,483 MULTIPLE PSYCHO ACTIVE AND 3754 03:21:35,550 --> 03:21:41,389 PSYCHO TROPIC DRUGS AND WE HAVE 3755 03:21:41,456 --> 03:21:48,729 COCAINE IF AND MORPHINE AND 3756 03:21:48,796 --> 03:21:50,331 SCOPOLAMINE AND WE CAN HAVE 3757 03:21:50,398 --> 03:21:53,367 CONVERSATIONS ABOUT THIS DRUGS 3758 03:21:53,434 --> 03:21:55,236 AS WE DO ABOUT CANNABIS. 3759 03:21:55,303 --> 03:21:56,604 WE JUST DON'T. 3760 03:21:56,671 --> 03:22:00,374 AND FOR WHATEVER HISTORICAL 3761 03:22:00,441 --> 03:22:01,943 REASON THAT'S IMPORTANT. 3762 03:22:02,009 --> 03:22:06,047 AND THE IMPORTANT BECAUSE IT'S 3763 03:22:06,113 --> 03:22:08,850 DEEPLY ROOTED AND YOU HAVE SEEN 3764 03:22:08,916 --> 03:22:13,020 THESE TYPES OF SLIDES IN THE 3765 03:22:13,087 --> 03:22:13,221 PAST. 3766 03:22:13,287 --> 03:22:15,056 CANNABIS WAS AN APPROVED 3767 03:22:15,122 --> 03:22:17,358 MEDICATION IN THE UNITED STATES 3768 03:22:17,425 --> 03:22:21,496 OF AMERICA IN 1860 AND 3769 03:22:21,562 --> 03:22:27,835 INTRODUCED IN THE UNITED STATES 3770 03:22:27,902 --> 03:22:29,370 PHARM 3771 03:22:29,437 --> 03:22:39,947 PHARMACO BOOKS AND A CAMPAIGN 3772 03:22:42,817 --> 03:22:44,418 STARTED WITHOUT STRONG MEDICAL 3773 03:22:44,485 --> 03:22:49,090 OR EVEN WEAK MEDICAL BACKGROUND 3774 03:22:49,156 --> 03:22:53,194 THAT COMPLETELY MOVED IT IN THE 3775 03:22:53,261 --> 03:22:55,096 OPPOSITE DIRECTION. 3776 03:22:55,162 --> 03:22:56,731 AND THIS IS ACTUALLY DRUGS THAT 3777 03:22:56,797 --> 03:23:01,702 MAKE YOU CRAZY AND YOU WOULD SEE 3778 03:23:01,769 --> 03:23:04,038 MOVIES LIKE REEFER MADNESS WHICH 3779 03:23:04,105 --> 03:23:06,140 IF YOU HAVE NOT SEEN I RECOMMEND 3780 03:23:06,207 --> 03:23:07,074 YOU SPENT 30 MINUTES SEEING 3781 03:23:07,141 --> 03:23:09,410 BECAUSE IT'S ENTERTAINING AND 3782 03:23:09,477 --> 03:23:11,245 HEAR CANNABIS IS PUBLIC ENEMY 3783 03:23:11,312 --> 03:23:17,718 NUMBER ONE AND THAT LED TO THE 3784 03:23:17,785 --> 03:23:23,190 ILLEGALIZATION OF CANNABIS WITH 3785 03:23:23,257 --> 03:23:25,693 THE CONTROLLED SUBSTANCE ACT. 3786 03:23:25,760 --> 03:23:32,233 AGAIN, AS SCIENTISTS AND OUR 3787 03:23:32,300 --> 03:23:33,334 COMMON PERSPECTIVE HERE HOW DO 3788 03:23:33,401 --> 03:23:34,502 WE LOOK AT THIS? 3789 03:23:34,569 --> 03:23:40,341 IS IT MEDICINE OR PUBLIC ENEMY 3790 03:23:40,408 --> 03:23:48,282 NUMBER ONE? 3791 03:23:48,349 --> 03:23:49,850 THERE'S THE FACT THAT THEY 3792 03:23:49,917 --> 03:23:51,385 HIDDEN CONSEQUENCES AND BRING 3793 03:23:51,452 --> 03:23:53,321 BIASSED OPINIONS AND ESPECIALLY 3794 03:23:53,387 --> 03:23:59,493 IF THEY'RE HIDDEN CANNOT BE 3795 03:23:59,560 --> 03:24:03,464 UNDERESTIMATED AND THIS POSTER 3796 03:24:03,531 --> 03:24:05,900 SAYS A TRUTH AND I WANT TO GIVE 3797 03:24:05,967 --> 03:24:07,902 AN EXAMPLE OF THIS. 3798 03:24:07,969 --> 03:24:12,840 SO I BRING THIS INTO A MORE 3799 03:24:12,907 --> 03:24:13,374 CONCR 3800 03:24:13,441 --> 03:24:16,577 CONCRETE GROUND SOME HAVE SEEN 3801 03:24:16,644 --> 03:24:20,214 THIS PAPER PERSISTENT CANNABIS 3802 03:24:20,281 --> 03:24:25,653 USERS SHOW NEURAL PSYCHOLOGICAL 3803 03:24:25,720 --> 03:24:31,392 DECLINE AND PUBLISHED IN 2012 3804 03:24:31,459 --> 03:24:39,033 AND IS AND THE COHORT IS NORTH 3805 03:24:39,100 --> 03:24:49,644 OF NEW ZEALAND WHICH FOLLOWED A 3806 03:24:49,844 --> 03:24:51,879 COUPLE RESIDENTS FROM BIRTH TO 3807 03:24:51,946 --> 03:24:57,385 38 AND THEY ASSESSED I.Q. AND 3808 03:24:57,451 --> 03:24:59,954 INTELLIGENT QUOTIENT I.Q. AND 3809 03:25:00,021 --> 03:25:03,457 DR. MIER CAME TO THE CONCLUSION 3810 03:25:03,524 --> 03:25:05,393 THAT THOSE INDIVIDUALS WHO USE 3811 03:25:05,459 --> 03:25:07,328 CANNABIS PERSISTENTLY HAD LOWER 3812 03:25:07,395 --> 03:25:08,596 I.Q. 3813 03:25:08,663 --> 03:25:13,567 SO THERE IS A LOT THAT CAN BE 3814 03:25:13,634 --> 03:25:16,337 SAID ABOUT THIS BUT I BET THAT 3815 03:25:16,404 --> 03:25:19,306 YOU HAVEN'T SEEN THIS PARTICULAR 3816 03:25:19,373 --> 03:25:19,507 PAPER. 3817 03:25:19,573 --> 03:25:23,377 THIS PARTICULAR PAPER WAS 3818 03:25:23,444 --> 03:25:29,383 PUBLISHED BY A NORWEGIAN 3819 03:25:29,450 --> 03:25:33,821 ECONOMIST WHO LOOKED AT THE DATA 3820 03:25:33,888 --> 03:25:37,491 AND THE SAME DATA MIER'S WORKED 3821 03:25:37,558 --> 03:25:38,959 WITH AND FOUND THE SAME RESULTS 3822 03:25:39,026 --> 03:25:41,162 COULD BE CONFOUNDED BY THE 3823 03:25:41,228 --> 03:25:46,167 SOCIAL ECONOMIC STATUS. 3824 03:25:46,233 --> 03:25:50,071 IN THIS SUGGESTED THE SOCIO 3825 03:25:50,137 --> 03:25:51,505 ECONOMIC STATUS IN CANNABIS WAS 3826 03:25:51,572 --> 03:25:52,807 RESPONSIBLE FOR THE LOWER I.Q. 3827 03:25:52,873 --> 03:25:53,641 IN THIS PARTICULAR POPULATION. 3828 03:25:53,708 --> 03:25:58,379 THE POINT I WANT TO MAKE NOW IS 3829 03:25:58,446 --> 03:26:00,381 NOT WHETHER MIER IS RIGHT, 3830 03:26:00,448 --> 03:26:01,315 THAT'S NOT THE POINT BUT THE 3831 03:26:01,382 --> 03:26:09,724 POINT IS I THINK WE ALL KNEW THE 3832 03:26:09,790 --> 03:26:11,425 PAPER AND VERY FEW HEARD OF THIS 3833 03:26:11,492 --> 03:26:12,960 PAPER AND WE HAVE NUMBERS FOR 3834 03:26:13,027 --> 03:26:16,097 THAT BECAUSE THE PAPER HAS BEEN 3835 03:26:16,163 --> 03:26:18,165 CITED ALMOST 2,000 TIMES AND 3836 03:26:18,232 --> 03:26:21,102 THIS PAPER HAS BEEN BARELY 132 3837 03:26:21,168 --> 03:26:21,302 TIMES. 3838 03:26:21,368 --> 03:26:25,673 SO THAT'S THE POINT I WANT TO 3839 03:26:25,740 --> 03:26:27,708 MAKE IS THAT IT'S NOT ONE OR THE 3840 03:26:27,775 --> 03:26:29,710 OTHER IS RIGHT BUT IT SHOULD 3841 03:26:29,777 --> 03:26:30,978 HAVE BEEN CITED APPROXIMATELY 3842 03:26:31,045 --> 03:26:32,046 THE SAME AMOUNT OF TIMES BECAUSE 3843 03:26:32,113 --> 03:26:34,348 THEY CAME OUT AT THE SAME TIME 3844 03:26:34,415 --> 03:26:35,750 SAYING TWO OPPOSITE THINGS 3845 03:26:35,816 --> 03:26:46,260 LOOKING AT THE SAME DATA. 3846 03:26:47,161 --> 03:26:49,230 THIS SHOWS A BIAS. 3847 03:26:49,296 --> 03:26:51,699 I FEEL THIS IS A WAY I DO IT 3848 03:26:51,766 --> 03:26:51,932 MYSELF. 3849 03:26:51,999 --> 03:26:53,400 I'M NOT CLAIMING IT'S SOMETHING 3850 03:26:53,467 --> 03:26:54,702 YOU SHOULD BE DOING BUT WHAT I 3851 03:26:54,769 --> 03:27:01,742 INTEREST I TRY TO MODIFY MY 3852 03:27:01,809 --> 03:27:02,877 BEHAVIOR AND SELF-AWARENESS AND 3853 03:27:02,943 --> 03:27:07,748 THE BIASES REFLECT AND SEEK 3854 03:27:07,815 --> 03:27:08,315 FEEDBACK. 3855 03:27:08,382 --> 03:27:12,353 THAT'S ALL SIMPLE IN THEORY. 3856 03:27:12,419 --> 03:27:13,721 EDUCATION AND LEARNING AND LEARN 3857 03:27:13,788 --> 03:27:18,926 OF DIFFERENT BIASES AND THE CASE 3858 03:27:18,993 --> 03:27:23,731 WE HAVE SEEN MEIER EXAMPLE IS A 3859 03:27:23,798 --> 03:27:29,637 CASE OF WHAT SOME PEOPLE CALM 3860 03:27:29,703 --> 03:27:32,506 BIAS AND YOU FEEL LIKE YOU KNOW 3861 03:27:32,573 --> 03:27:37,144 KIND OF THIS IS BAD FOR YOU SO 3862 03:27:37,211 --> 03:27:39,814 WHEN YOU SEE A PAPER THAT SAYS 3863 03:27:39,880 --> 03:27:46,887 IT'S BAD FOR YOU, IF YOU SEE A 3864 03:27:46,954 --> 03:27:49,190 PAPER THAT SHOWS OPPOSITE IT 3865 03:27:49,256 --> 03:27:52,459 RAISES YOUR DECISION AND MINDFUL 3866 03:27:52,526 --> 03:27:55,529 DECISION MAKING AND PAUSE AND 3867 03:27:55,596 --> 03:28:01,168 REFLECT AND CONSIDER 3868 03:28:01,235 --> 03:28:03,938 ALTERNATIVES AND AND IF YOU'RE 3869 03:28:04,004 --> 03:28:05,272 AN ADVOCATE FOR CANNABIS TALK TO 3870 03:28:05,339 --> 03:28:08,876 A PHYSICIAN THEY HAVE DIFFERENT 3871 03:28:08,943 --> 03:28:09,143 OPINIONS. 3872 03:28:09,210 --> 03:28:10,678 IF YOU'RE A PHYSICIAN TALK TO AN 3873 03:28:10,744 --> 03:28:11,812 ADVOCATE AND IF YOU'RE A 3874 03:28:11,879 --> 03:28:13,614 SCIENTIST LIKE I HAPPEN TO BE 3875 03:28:13,681 --> 03:28:14,882 TALK TO BOTH BUT PLEASE BUT THE 3876 03:28:14,949 --> 03:28:16,383 DATA FIRST BECAUSE AT THE END OF 3877 03:28:16,450 --> 03:28:19,153 THE DAY ALL WE NEED TO DO IS 3878 03:28:19,220 --> 03:28:21,121 LOOK AT THE DATA AND EVERYTHING 3879 03:28:21,188 --> 03:28:22,990 THAT WE INTERPRET FROM THE DATA 3880 03:28:23,057 --> 03:28:23,858 IS NARRATIVE. 3881 03:28:23,924 --> 03:28:25,693 THE DATA ARE THE EMPIRICAL 3882 03:28:25,759 --> 03:28:27,895 GROUND IN WHICH WE ALL STAND. 3883 03:28:27,962 --> 03:28:29,930 AND CULTIVATE AN OPEN MIND SET. 3884 03:28:29,997 --> 03:28:32,032 IF THE STUDY CHALLENGES YOUR 3885 03:28:32,099 --> 03:28:34,468 FURTHER IDEA, DON'T IGNORE IT 3886 03:28:34,535 --> 03:28:38,672 AND THAT IS UNFORTUNATELY WHAT 3887 03:28:38,739 --> 03:28:39,773 HAPPENED WITH THE MEIER PAPER. 3888 03:28:39,840 --> 03:28:42,610 I WANT TO GO BACK TO THIS TO 3889 03:28:42,676 --> 03:28:46,714 HIGHLIGHT SOMETHING ABOUT THE 3890 03:28:46,780 --> 03:28:57,324 TITLE OF THE TWO TALKS ONE HAS 3891 03:28:57,524 --> 03:29:00,327 ALMOST AN IMPLICIT CAUSALITY AND 3892 03:29:00,394 --> 03:29:02,029 CAUSALITY IS IMPLIED NOT IN SO 3893 03:29:02,096 --> 03:29:06,333 MANY WORDS BUT CLEARLY IMPLIED. 3894 03:29:06,400 --> 03:29:06,867 WHEREAS THE PAPER AND 3895 03:29:06,934 --> 03:29:09,136 CORRELATION IS IN THE TITLE. 3896 03:29:09,203 --> 03:29:13,908 AND THAT IS MY SEGUE FOR GOING 3897 03:29:13,974 --> 03:29:20,080 TO ISSUE OF CAUSAL EVIDENCE. 3898 03:29:20,147 --> 03:29:22,049 SO WE ALL KNOW CORRELATION IS 3899 03:29:22,116 --> 03:29:24,018 NOT CAUSATION. 3900 03:29:24,084 --> 03:29:26,353 WE FEEL CORRELATION IS NOT WILL 3901 03:29:26,420 --> 03:29:28,055 A POSITION BUT SOMEWHAT SIMILAR 3902 03:29:28,122 --> 03:29:29,390 TO CAUSATION. 3903 03:29:29,456 --> 03:29:33,694 LET ME TELL YOU OFF THE BAT, HE 3904 03:29:33,761 --> 03:29:35,029 WAS WRONG. 3905 03:29:35,095 --> 03:29:36,263 CONTINGENCY IS NOT CAUSE. 3906 03:29:36,330 --> 03:29:37,531 WE HAVE TWO VERY DIFFERENT 3907 03:29:37,598 --> 03:29:38,832 THINGS. 3908 03:29:38,899 --> 03:29:40,501 ACCORDING TO THIS GUY. 3909 03:29:40,567 --> 03:29:45,739 SO IF CAUSATION WERE THE SAME AS 3910 03:29:45,806 --> 03:29:50,878 CAUSATION IN THESE HEADLINES 3911 03:29:50,945 --> 03:29:56,083 WOULD BE AND WELL, IF YOU RUN A 3912 03:29:56,150 --> 03:29:58,118 CROSS-SECTIONAL ANALYSIS IN MANY 3913 03:29:58,185 --> 03:30:02,189 PLACES YOU WOULD SEE MOST PEOPLE 3914 03:30:02,256 --> 03:30:08,262 ARE BORN OF CUBAN DISSENT AND 3915 03:30:08,329 --> 03:30:15,970 PEOPLE WHO OF JEWISH DESCENT AND 3916 03:30:16,036 --> 03:30:18,339 HOW DO WE ESTABLISH CAUSALITY IN 3917 03:30:18,405 --> 03:30:18,639 OUR WORK? 3918 03:30:18,706 --> 03:30:21,075 MOST KNOW CAUSALITY HAS BEEN IB 3919 03:30:21,141 --> 03:30:26,547 A BIG TOPIC FROM SINCE ARISTOTLE 3920 03:30:26,613 --> 03:30:33,120 AND WILL SAY FROM MY MODEST 3921 03:30:33,187 --> 03:30:38,892 WHICH I HAVE NOT COLLABORATED IN 3922 03:30:38,959 --> 03:30:45,132 ANY WAY, SHAPE OR FORM AND WE 3923 03:30:45,199 --> 03:30:48,902 SCIENTISTS USE DAILY A VIEW OF 3924 03:30:48,969 --> 03:30:52,639 CAUSALITY THAT IS RADICALLY NEW 3925 03:30:52,706 --> 03:30:56,877 AND THE VIEW OF CAUSALITY WAS IN 3926 03:30:56,944 --> 03:31:01,715 THE BOOK CALLED THE DISCOURSE OF 3927 03:31:01,782 --> 03:31:04,651 FLOATING BODIES AND GALILEO 3928 03:31:04,718 --> 03:31:08,122 WROTE THE EFFECT FOLLOWS AND 3929 03:31:08,188 --> 03:31:09,490 REMOVED THE EFFECT WILL IS 3930 03:31:09,556 --> 03:31:09,723 REMOVED. 3931 03:31:09,790 --> 03:31:11,392 WHAT HE MEANS IS SIMPLE. 3932 03:31:11,458 --> 03:31:14,695 WE DO THIS ALL THE TIME YOU WANT 3933 03:31:14,762 --> 03:31:17,631 TO SHOW THE ACTIVATION OF 3934 03:31:17,698 --> 03:31:23,203 CANNABINOIDS IN THE BRAIN CAUSES 3935 03:31:23,270 --> 03:31:24,438 HYPERTHERMIA, CAUSALITY? 3936 03:31:24,505 --> 03:31:27,074 THE CANNABINOID RECEPTOR AGONIST 3937 03:31:27,141 --> 03:31:33,647 AND GIVE THE ANTAGONIST AND 3938 03:31:33,714 --> 03:31:35,416 BLOCK THE AFFECT AND REMOVE THE 3939 03:31:35,482 --> 03:31:39,053 CAUSE AND THE AFFECT IS REMOVED. 3940 03:31:39,119 --> 03:31:39,953 THAT'S ESSENTIALLY WHAT 3941 03:31:40,020 --> 03:31:41,455 PHILOSOPHERS CALL AN 3942 03:31:41,522 --> 03:31:42,022 INTERVENTIONIST APPROACH TO 3943 03:31:42,089 --> 03:31:51,999 CAUSALITY. 3944 03:31:52,066 --> 03:31:57,671 AND IT'S VERY SIMPLE. 3945 03:31:57,738 --> 03:31:59,406 WE HAVE CAN PLAN EXPERIMENTS 3946 03:31:59,473 --> 03:32:03,444 THAT ARE MORE CONE OF CONTROLLED 3947 03:32:03,510 --> 03:32:05,746 AND HARD FOR OBSERVATION AND 3948 03:32:05,813 --> 03:32:09,450 STUFF FROM ASTRONOMY AND 3949 03:32:09,516 --> 03:32:11,718 OBSERVATION PLAYS AN IMPORTANT 3950 03:32:11,785 --> 03:32:12,719 ROLE IN CANNABIS RESEARCH. 3951 03:32:12,786 --> 03:32:15,989 SO HOW DO WE ADDRESS THE ISSUE 3952 03:32:16,056 --> 03:32:17,724 OF CAUSALITY IN CANNABIS 3953 03:32:17,791 --> 03:32:17,991 RESEARCH? 3954 03:32:18,058 --> 03:32:21,695 THERE ARE WAYS TO DO THAT AND I 3955 03:32:21,762 --> 03:32:25,666 THINK ARE PRETTY STRONG. 3956 03:32:25,732 --> 03:32:28,702 FOR EXAMPLE WE CAN USE 3957 03:32:28,769 --> 03:32:31,472 DISCORDANT SIBLING/TWIN DESIGN 3958 03:32:31,538 --> 03:32:35,776 AND COMPARE OUTCOMES WHEN HO 3959 03:32:35,843 --> 03:32:41,215 HOMOZYGOTIC TWINS ARE DISCORDANT 3960 03:32:41,281 --> 03:32:43,183 IN THEIR CANNABIS USE AND THIS 3961 03:32:43,250 --> 03:32:44,518 APPROACH HAS BEEN USED 3962 03:32:44,585 --> 03:32:47,387 CLASSICALLY TO DEFINE THE 3963 03:32:47,454 --> 03:32:49,289 GENETIC COMPONENT OF 3964 03:32:49,356 --> 03:32:51,592 SCHIZOPHRENIA IN THE 1960s. 3965 03:32:51,658 --> 03:32:53,994 SO THERE'S AN AREA OF 3966 03:32:54,061 --> 03:32:56,597 OPTIMIZATION AND TAKES ADVANTAGE 3967 03:32:56,663 --> 03:32:59,233 OF THE FACT THAT NEXT IS SINGLE 3968 03:32:59,299 --> 03:33:04,238 NUCLEOTIDE POLYMORPHISMS OCCUR 3969 03:33:04,304 --> 03:33:04,505 RANDOMLY. 3970 03:33:04,571 --> 03:33:06,740 THAT'S THE RANDOM CONTROL IN A 3971 03:33:06,807 --> 03:33:08,809 WIDE POPULATION AND SO WE CAN 3972 03:33:08,876 --> 03:33:12,779 USE THE GENETIC VARIANTS 3973 03:33:12,846 --> 03:33:13,981 ASSOCIATED WITH CANNABIS USE AS 3974 03:33:14,047 --> 03:33:16,483 A VARIABLE TO TEST THE CAUSAL 3975 03:33:16,550 --> 03:33:20,187 EFFECT OF CANNABIS ON A SPECIFIC 3976 03:33:20,254 --> 03:33:22,956 OUTCOME AND WE'RE LUCKY BECAUSE 3977 03:33:23,023 --> 03:33:25,692 THE RESEARCH IS GENETIC VARIANCE 3978 03:33:25,759 --> 03:33:27,561 ASSOCIATED WITH CANNABIS USE AND 3979 03:33:27,628 --> 03:33:34,868 THE RECEPTOR VARIANTS AND THE 3980 03:33:34,935 --> 03:33:40,073 AND THE FATTY ACID GENE 3981 03:33:40,140 --> 03:33:41,375 RECOGNIZED. 3982 03:33:41,441 --> 03:33:45,712 AND THEN THERE IS INTERVENTIONS. 3983 03:33:45,779 --> 03:33:47,114 PAUSE INTERVENTIONS ARE A COOL 3984 03:33:47,181 --> 03:33:51,185 WAY OF DOING THAT AND MAYBE SOME 3985 03:33:51,251 --> 03:33:53,687 LOOK INTO THAT AND CAN 3986 03:33:53,754 --> 03:33:56,857 CAPITALIZE AND THE FACT THAT AN 3987 03:33:56,924 --> 03:33:58,025 EXTERNAL EVENT OR PUBLIC 3988 03:33:58,091 --> 03:33:59,793 INTERVENTION AFFECTS IT ONE ONE 3989 03:33:59,860 --> 03:34:01,495 POPULATION AND SAY IN THE STATE 3990 03:34:01,562 --> 03:34:03,530 OF COLORADO AND NOT IN THE STATE 3991 03:34:03,597 --> 03:34:04,364 OF NORTH DAKOTA OR SOMETHING 3992 03:34:04,431 --> 03:34:09,169 LIKE THAT. 3993 03:34:09,236 --> 03:34:10,671 THEY HAVE TO BE DEMOGRAPHICALLY 3994 03:34:10,737 --> 03:34:13,040 SIMILAR AND YOU GET THE DRIFT. 3995 03:34:13,106 --> 03:34:16,610 AND FINALLY WHAT I DO 3996 03:34:16,677 --> 03:34:18,645 EXPERIMENTAL STUDIES WE CAN RUN 3997 03:34:18,712 --> 03:34:20,981 CONTROLLED STUDIES TO PERMIT 3998 03:34:21,048 --> 03:34:23,784 RANDOM ASSIGNMENT OF SUBJECTS 3999 03:34:23,850 --> 03:34:25,352 AND COULD BE HUMAN SUBJECTS FOR 4000 03:34:25,419 --> 03:34:29,022 THE ADMINISTRATION OF A DEFINED 4001 03:34:29,089 --> 03:34:32,059 QUANTITY AND TYPE OF CANNABIS OR 4002 03:34:32,125 --> 03:34:34,695 CANNABINOID AND INCLUDES PLACEBO 4003 03:34:34,761 --> 03:34:35,295 CONTROL RANDOMIZED CLINICAL 4004 03:34:35,362 --> 03:34:38,932 TRIALS. 4005 03:34:38,999 --> 03:34:43,704 AND THIS WAS MY SEGUE TO THE 4006 03:34:43,770 --> 03:34:45,005 NEXT AND THE CONFOUNDER AND THE 4007 03:34:45,072 --> 03:34:49,209 NEXT ISSUE I WANTED TO DISCUSS 4008 03:34:49,276 --> 03:34:50,444 AND LOOK AT THE CANNABIS AND 4009 03:34:50,510 --> 03:34:55,115 CANNABINOID. 4010 03:34:55,182 --> 03:35:00,120 AND I WAS GOING TO GO OVER THAT 4011 03:35:00,187 --> 03:35:04,691 IN SOME DETAIL. 4012 03:35:04,758 --> 03:35:09,463 WE ALL RECOGNIZE THE PLAN 4013 03:35:09,529 --> 03:35:15,469 DIVERSITY IS THE CONFOUNDER IN 4014 03:35:15,535 --> 03:35:21,174 OUR STUDIES AND IF YOU GO TO ANY 4015 03:35:21,241 --> 03:35:22,943 DISPENSARY IN THE STATE OF 4016 03:35:23,010 --> 03:35:25,512 CALIFORNIA YOU FIND HUNDREDS OF 4017 03:35:25,579 --> 03:35:29,283 PRODUCTS AND YOU HAVE YOUR DABS 4018 03:35:29,349 --> 03:35:31,952 AND YOUR PRE-ROLL, ETCETERA. 4019 03:35:32,019 --> 03:35:33,954 DIFFERENT NAMES, DIFFERENT 4020 03:35:34,021 --> 03:35:34,788 PRICES, DIFFERENT MARKET 4021 03:35:34,855 --> 03:35:35,122 PRESENTATION. 4022 03:35:35,188 --> 03:35:38,058 THIS MAY BE OVERWHELMING TO SOME 4023 03:35:38,125 --> 03:35:39,660 BUT IT WAS NOT OVERWHELMING TO 4024 03:35:39,726 --> 03:35:41,862 ME WHEN I FIRST SAW ITS. 4025 03:35:41,928 --> 03:35:43,497 I REMEMBER WHEN I FIRST ARRIVED 4026 03:35:43,563 --> 03:35:44,865 IN THIS COUNTRY A LONG TIME AGO 4027 03:35:44,931 --> 03:35:48,035 I REMEMBER THIS. 4028 03:35:48,101 --> 03:35:51,104 TO ME THIS WAS LIKE ALIEN. 4029 03:35:51,171 --> 03:35:53,473 WHY DO THEY NEED SO MANY POTATO 4030 03:35:53,540 --> 03:35:56,977 CHIPS? 4031 03:35:57,044 --> 03:35:58,378 I STILL HAVEN'T GOTTEN USED TO 4032 03:35:58,445 --> 03:36:02,349 IT, I HAVE TO ADMIT. 4033 03:36:02,416 --> 03:36:04,484 SO THE THING IS DIFFERENT 4034 03:36:04,551 --> 03:36:05,118 CANNABIS PRODUCTS DIFFER AND 4035 03:36:05,185 --> 03:36:05,686 THAT'S IMPORTANT. 4036 03:36:05,752 --> 03:36:07,087 THEY'RE NOT JUST THE SAME. 4037 03:36:07,154 --> 03:36:09,256 YOU CAN'T TREAT THEM AS IF THEY 4038 03:36:09,323 --> 03:36:10,190 WERE THE SAME. 4039 03:36:10,257 --> 03:36:12,426 THEY'RE DIFFERENT BUT IN WHAT? 4040 03:36:12,492 --> 03:36:16,663 MODE OF VIEWS WE DISCUSSED 4041 03:36:16,730 --> 03:36:27,274 BEFORE AND IN THE EXCIPIENTS AND 4042 03:36:29,276 --> 03:36:33,513 LIKE POTATO CHIPS ARE ABOUT 4043 03:36:33,580 --> 03:36:35,415 POTATOES, SALT AND OIL THIS IS 4044 03:36:35,482 --> 03:36:36,650 ABOUT THC. 4045 03:36:36,717 --> 03:36:38,952 IF THERE WERE NO THC WE WOULDN'T 4046 03:36:39,019 --> 03:36:49,162 BE HERE. 4047 03:36:49,963 --> 03:36:55,869 AND WE'RE HERE IN THE MEETING 4048 03:36:55,936 --> 03:37:06,480 THANKS TO THC AND I WENT TO AN 4049 03:37:12,352 --> 03:37:15,622 EVENT IN SAN BERNARDINO AND SEE 4050 03:37:15,689 --> 03:37:16,757 DIFFERENT TYPES OF CANNABIS AND 4051 03:37:16,823 --> 03:37:17,791 SOME ARE SHORT AND SOME ARE 4052 03:37:17,858 --> 03:37:20,727 FULLY AND SOME ARE FULL OF 4053 03:37:20,794 --> 03:37:23,130 FLOWERS AND RICH IN A PARTICULAR 4054 03:37:23,196 --> 03:37:28,301 OIL AND SMELL STRONGLY. 4055 03:37:28,368 --> 03:37:36,309 IT'S VERY INTERESTING WE HAVE 4056 03:37:36,376 --> 03:37:36,943 DIFFERENT TYPES OF CANNABIS 4057 03:37:37,010 --> 03:37:41,114 NAMES THROWN AROUND ALL THE TIME 4058 03:37:41,181 --> 03:37:41,748 BUT WHAT'S THE SCIENCE BEHIND 4059 03:37:41,815 --> 03:37:41,982 IT? 4060 03:37:42,048 --> 03:37:43,784 LET ME TAKE YOU TO A PAPER THAT 4061 03:37:43,850 --> 03:37:46,787 GOES SPECIFICALLY TO THE 4062 03:37:46,853 --> 03:37:48,321 QUESTION OF THE SCIENCE BEHIND 4063 03:37:48,388 --> 03:37:49,523 THE VARIETY. 4064 03:37:49,589 --> 03:37:51,892 SO IN THIS PAPER A GROUP OF 4065 03:37:51,958 --> 03:38:00,801 RESEARCHERS IN THE NETHERLANDS 4066 03:38:00,867 --> 03:38:05,372 TOOK A HUNDRED VARIETIES OF 4067 03:38:05,439 --> 03:38:08,275 CANNABIS AND FOR PLANT PEOPLE 4068 03:38:08,341 --> 03:38:18,819 PREFER TO USE VARIATALS AND 4069 03:38:27,594 --> 03:38:30,630 STRAINS AND THERE'S COMMENTARIES 4070 03:38:30,697 --> 03:38:30,964 ABOUT THAT. 4071 03:38:31,031 --> 03:38:33,700 AND THEY DID TWO THINGS. 4072 03:38:33,767 --> 03:38:44,077 YOU CAN SEE HERE. 4073 03:38:46,112 --> 03:38:48,348 THEY LOOKED AT THE GENOME AND 4074 03:38:48,415 --> 03:38:52,586 THEN THEY LOOKED AT TERPENE AND 4075 03:38:52,652 --> 03:38:53,553 CANNABINOID COMPOSITION AND YOU 4076 03:38:53,620 --> 03:38:59,493 SEE THE COMPONENT ANALYSIS AND 4077 03:38:59,559 --> 03:39:07,000 YOU CAN SEE THE CULTIVARS ARE 4078 03:39:07,067 --> 03:39:08,301 CLUSTERED TOGETHER. 4079 03:39:08,368 --> 03:39:18,912 SOME HAVE 100% SATIVA AND SOME 4080 03:39:20,547 --> 03:39:20,714 I 4081 03:39:20,780 --> 03:39:21,014 I 4082 03:39:21,081 --> 03:39:22,382 INDICA AND ACCORDING TO 4083 03:39:22,449 --> 03:39:23,650 CANNABINOID COMPOSITION. 4084 03:39:23,717 --> 03:39:27,354 THIS MEANS THEY'RE THE SAME 4085 03:39:27,420 --> 03:39:29,422 GENETICALLY AND CHEMICALLY THE 4086 03:39:29,489 --> 03:39:39,599 SAME. 4087 03:39:46,206 --> 03:39:48,575 YOU CAN'T TAKE THIS TO YOUR LAB 4088 03:39:48,642 --> 03:39:52,045 AND I COULD HAVE A LONG 4089 03:39:52,112 --> 03:39:57,150 EDITORIAL ON THIS BUT THE 4090 03:39:57,217 --> 03:40:07,761 CANNABIS CULTIVARS AND HERE'S MY 4091 03:40:24,544 --> 03:40:25,679 TWO CENTS. 4092 03:40:25,745 --> 03:40:29,849 FIRST, PLEASE IGNORE MARKETING 4093 03:40:29,916 --> 03:40:30,517 GOALS. 4094 03:40:30,584 --> 03:40:35,689 DON'T LISTEN TO THE CANNABIS 4095 03:40:35,755 --> 03:40:39,092 INDUS 4096 03:40:39,159 --> 03:40:44,297 INDUSTRY, INDICA AND SATIVA ARE 4097 03:40:44,364 --> 03:40:46,566 VERNACULAR TERMS. 4098 03:40:46,633 --> 03:40:49,536 THEY'VE BEEN HIGH JACKED FOR 4099 03:40:49,603 --> 03:40:51,705 MARKETING PURPOSE AND PAINS ME 4100 03:40:51,771 --> 03:40:53,340 TO HEAR COLLEAGUES USING THE 4101 03:40:53,406 --> 03:40:55,108 WORDS NOT BECAUSE THEY'RE WRONG 4102 03:40:55,175 --> 03:40:56,543 BUT WE'RE BORROWING THEM FROM 4103 03:40:56,610 --> 03:40:57,711 THE INDUSTRY AND PUT THERE FROM 4104 03:40:57,777 --> 03:41:03,149 THE INDUSTRY TO SELL STUFF. 4105 03:41:03,216 --> 03:41:06,553 WE HAVE NAMES FOR THIS, 4106 03:41:06,620 --> 03:41:11,424 SYNERGISM AND ALL KIND OF THINGS 4107 03:41:11,491 --> 03:41:16,029 TO USE AND ENTOURAGE EFFECT IS 4108 03:41:16,096 --> 03:41:16,563 NOT HELPFUL TO THE ROOM 4109 03:41:16,630 --> 03:41:20,333 DISCOURSE AND NOT A GOOD IDEA IF 4110 03:41:20,400 --> 03:41:23,937 YOU'RE A SCIENTIST. 4111 03:41:24,004 --> 03:41:25,338 I DON'T WANT TO SOUND EXTREME IN 4112 03:41:25,405 --> 03:41:31,277 MY POSITION BUT WE CANNOT IGNORE 4113 03:41:31,344 --> 03:41:32,746 CANNABIS IS TASTING A CERTAIN 4114 03:41:32,812 --> 03:41:34,514 WAY TO THE USER IS IMPORTANT TO 4115 03:41:34,581 --> 03:41:37,017 THE USER NOT JUST THE HUMAN USER 4116 03:41:37,083 --> 03:41:37,717 BUT ANIMALS. 4117 03:41:37,784 --> 03:41:41,721 IF YOU CAN SMELL IT, I CAN 4118 03:41:41,788 --> 03:41:43,323 PROMISE A RAT CAN SMELL BETTER 4119 03:41:43,390 --> 03:41:47,827 THAN YOU CAN AND DON'T IGNORE 4120 03:41:47,894 --> 03:41:49,229 THE AROMA. 4121 03:41:49,295 --> 03:41:51,498 THERE'S CONSEQUENCES, FOR 4122 03:41:51,564 --> 03:41:54,534 EXAMPLE, THEY ARE CAN MAKE THE 4123 03:41:54,601 --> 03:41:56,336 DIFFERENCE BLIND OR NOT BLUE 4124 03:41:56,403 --> 03:42:03,343 LINE OR HAVE A PLACEBO JUST 4125 03:42:03,410 --> 03:42:05,979 CONSIDER IS THAT.IUE 4126 03:42:06,046 --> 03:42:06,546 LINE OR HAVE A PLACEBO JUST 4127 03:42:06,613 --> 03:42:07,614 CONSIDER IS NUE 4128 03:42:07,681 --> 03:42:08,181 LINE OR HAVE A PLACEBO JUST 4129 03:42:08,248 --> 03:42:09,249 CONSIDER IS DUE 4130 03:42:09,315 --> 03:42:09,816 LINE OR HAVE A PLACEBO JUST 4131 03:42:09,883 --> 03:42:10,250 CONSIDER IS THAT.E 4132 03:42:10,316 --> 03:42:10,817 LINE OR HAVE A PLACEBO JUST 4133 03:42:10,884 --> 03:42:11,284 CONSIDER IS THAT.INE 4134 03:42:11,351 --> 03:42:11,918 OR HAVE A PLACEBO JUST CONSIDER 4135 03:42:11,985 --> 03:42:12,218 IS THAT.NE 4136 03:42:12,285 --> 03:42:12,852 OR HAVE A PLACEBO JUST CONSIDER 4137 03:42:12,919 --> 03:42:13,119 IS THAT.E 4138 03:42:13,186 --> 03:42:13,753 OR HAVE A PLACEBO JUST CONSIDER 4139 03:42:13,820 --> 03:42:14,354 IS TH OR 4140 03:42:14,421 --> 03:42:14,988 HAVE A PLACEBO JUST CONSIDER IS 4141 03:42:15,055 --> 03:42:15,188 THAT. 4142 03:42:15,255 --> 03:42:15,889 THERE'S SUCH A THING AS THE DOSE 4143 03:42:15,955 --> 03:42:17,524 OF THE DRUG AND THC IS A 1 4144 03:42:17,590 --> 03:42:21,695 MILLIGRAM, 10 MILLIGRAM AND 4145 03:42:21,761 --> 03:42:31,237 THOSE ARE DIFFERENT ANIMALS. 4146 03:42:31,304 --> 03:42:39,512 PAY ATTENTION TO WHERE IT'S 4147 03:42:39,579 --> 03:42:41,948 DOING IT'S JOB IF IT'S THE BRAIN 4148 03:42:42,015 --> 03:42:42,882 OR IMMUNE CELLS. 4149 03:42:42,949 --> 03:42:46,619 AND FINALLY PAY TENSION TO 4150 03:42:46,686 --> 03:42:50,290 EXCIPIENTS THE STUFF INDUSTRY 4151 03:42:50,356 --> 03:42:50,590 PUTS. 4152 03:42:50,657 --> 03:42:54,127 FOR EXAMPLE, THE POLY ETHYLENE 4153 03:42:54,194 --> 03:42:59,499 RECALL OR VITAMIN A WAS 4154 03:42:59,566 --> 03:43:00,467 MENTIONED BEFORE. 4155 03:43:00,533 --> 03:43:02,569 THESE CAN INTERACTION 4156 03:43:02,635 --> 03:43:04,904 FUNCTIONALLY WITH THC AND HAVE 4157 03:43:04,971 --> 03:43:05,939 EFFECTS ON THEIR OWN. 4158 03:43:06,005 --> 03:43:08,541 I'LL QUICKLY OVER TWO CASE 4159 03:43:08,608 --> 03:43:10,643 STUDIES. 4160 03:43:10,710 --> 03:43:12,378 CANNABIS AND PSYCHOSIS AND 4161 03:43:12,445 --> 03:43:15,148 CANNABIS AS AN ANALGESIC. 4162 03:43:15,215 --> 03:43:17,417 THAT'S THE CAUSED PSYCHOSIS. 4163 03:43:17,484 --> 03:43:18,752 THIS IS A BRUTE WAY OF PUTTING 4164 03:43:18,818 --> 03:43:20,754 IT BUT THE WAY I THINK WE SHOULD 4165 03:43:20,820 --> 03:43:22,655 ADDRESS IT SO WE DON'T HIDE 4166 03:43:22,722 --> 03:43:24,224 BEHIND WORDS. 4167 03:43:24,290 --> 03:43:26,793 SO THAT'S CANNABIS CAUSED 4168 03:43:26,860 --> 03:43:27,060 PSYCHOSIS. 4169 03:43:27,127 --> 03:43:31,965 LET'S REFINE THE QUESTION TO TWO 4170 03:43:32,031 --> 03:43:33,433 RELATED QUESTIONS. 4171 03:43:33,500 --> 03:43:35,068 THAT'S CANNABIS CAUSE ACUTE 4172 03:43:35,135 --> 03:43:39,038 PSYCHOTIC SYMPTOMS AND THERE'S 4173 03:43:39,105 --> 03:43:41,207 PERCEPTUAL DISTURBANCES SUCH AS 4174 03:43:41,274 --> 03:43:42,776 ALTERATIONS IN SPACE AND TIME 4175 03:43:42,842 --> 03:43:45,278 AND VISUAL ILLUSION, ETCETERA. 4176 03:43:45,345 --> 03:43:49,749 WE CAN SPEAK OF CANNABIS INDUCED 4177 03:43:49,816 --> 03:43:52,719 PSYCHOSIS AND IF WE ASK THE 4178 03:43:52,786 --> 03:43:56,823 PERSON, OKAY, SO YOU'RE SEEING 4179 03:43:56,890 --> 03:43:57,690 EVERYTHING IN THAT PARTICULAR 4180 03:43:57,757 --> 03:44:00,460 COLOR AND SEEMS LIKE IT'S GOING 4181 03:44:00,527 --> 03:44:01,694 SLOWLY, WHY? 4182 03:44:01,761 --> 03:44:04,197 WELL, BECAUSE I'M HIGH. 4183 03:44:04,264 --> 03:44:06,800 IF THAT'S THE PERSON YOU HAVE 4184 03:44:06,866 --> 03:44:12,205 INTACT REALITY AND THE CAN'T BE 4185 03:44:12,272 --> 03:44:13,673 TALKING ABOUT PSYCHOSIS AND WHAT 4186 03:44:13,740 --> 03:44:16,176 MATTERS TO US REGARDLESS OF 4187 03:44:16,242 --> 03:44:18,144 WHETHER WE'RE PARENTS OR NOT 4188 03:44:18,211 --> 03:44:21,548 CLEARLY IT'S IMPORTANT TO KNOW 4189 03:44:21,614 --> 03:44:24,417 WHETHER USE OF CANNABIS AND WHEN 4190 03:44:24,484 --> 03:44:26,553 THERE'S YOUNG WOMEN AND MEN 4191 03:44:26,619 --> 03:44:28,188 SUSCEPTIBLE TO DEVELOPING 4192 03:44:28,254 --> 03:44:30,523 PSYCHOSIS AND THAT IS THE 4193 03:44:30,590 --> 03:44:31,991 QUESTION I WOULD LIKE TO RECALL 4194 03:44:32,058 --> 03:44:34,961 FOCUS QUICKLY ON. 4195 03:44:35,028 --> 03:44:37,564 AND REALLY THIS ALL STARTED WITH 4196 03:44:37,630 --> 03:44:39,465 THIS PARTICULAR PAPER THE FACE 4197 03:44:39,532 --> 03:44:43,870 THAT LAUNCHED A THOUSAND SHIPS 4198 03:44:43,937 --> 03:44:45,505 THE FAMOUS PAPER FROM SWEDISH 4199 03:44:45,572 --> 03:44:51,311 STUDY OF 1987 WHERE 4200 03:44:51,377 --> 03:44:54,647 COLLABORATORS SHOWED STARTING 4201 03:44:54,714 --> 03:44:59,352 FROM A COHORT OF 45,000 USING 4202 03:44:59,419 --> 03:45:04,624 CANNABIS DURING ADOLESCENTS WAS 4203 03:45:04,691 --> 03:45:06,726 RECALL ASSOCIATED SIX TIMES MORE 4204 03:45:06,793 --> 03:45:08,394 IN DEVELOPING PSYCHOSIS IN 4205 03:45:08,461 --> 03:45:08,795 ADULTHOOD. 4206 03:45:08,862 --> 03:45:10,096 LET'S LOOK AT THE CONTEXT. 4207 03:45:10,163 --> 03:45:13,700 THE CONTEXT, THE BACKGROUND IS 4208 03:45:13,766 --> 03:45:15,935 AT THAT POINT WE'RE ALREADY 4209 03:45:16,002 --> 03:45:17,003 EVERYONE INCLUDING THE 4210 03:45:17,070 --> 03:45:19,505 SCIENTISTS WE DON'T LIVE IN AN 4211 03:45:19,572 --> 03:45:21,040 IVORY TOWER, WE'RE HEARING 4212 03:45:21,107 --> 03:45:23,843 THINGS ABOUT CANNABIS MAKING 4213 03:45:23,910 --> 03:45:24,577 PEOPLE CRAZY. 4214 03:45:24,644 --> 03:45:26,746 WHAT I BROUGHT UP HERE IS MAYBE 4215 03:45:26,813 --> 03:45:31,584 THE QUOTE, UNQUOTE, FUN EXAMPLE 4216 03:45:31,651 --> 03:45:33,953 BUT FUN EXAMPLE BECAUSE IT'S SO 4217 03:45:34,020 --> 03:45:34,454 EXTREME. 4218 03:45:34,520 --> 03:45:40,059 THIS IS AN ARTICLE THAT APPEARED 4219 03:45:40,126 --> 03:45:47,500 IN THE 1940s IN A NEWSPAPER. 4220 03:45:47,567 --> 03:45:50,136 ENTITLED EVIL MEXICAN PLANT THAT 4221 03:45:50,203 --> 03:45:53,206 DRIVE YOU INSANE AND A MEXICAN 4222 03:45:53,273 --> 03:45:56,175 OF THE LOWER CLASS WHO SMOKED AN 4223 03:45:56,242 --> 03:45:57,243 MARIJUANA CIGARETTE BECAME 4224 03:45:57,310 --> 03:45:59,178 INSANE AND KILLED A POLICEMAN 4225 03:45:59,245 --> 03:46:00,980 AND BADLY WOUNDED THREE OTHERS. 4226 03:46:01,047 --> 03:46:02,949 IT'S WRONG ON SO MANY LEVELS I 4227 03:46:03,016 --> 03:46:05,518 DON'T EVEN WANT TO START BUT TO 4228 03:46:05,585 --> 03:46:09,188 POINT OUT IF YOU THINK THIS IS 4229 03:46:09,255 --> 03:46:11,057 SOMETHING THAT HAPPENED IN THE 4230 03:46:11,124 --> 03:46:13,126 1940s ISN'T HAPPENING NOW, YOU'D 4231 03:46:13,192 --> 03:46:14,861 BE WRONG BECAUSE I HEARD THE 4232 03:46:14,928 --> 03:46:15,929 SAME PHRASE ON FOX NEWS TWO 4233 03:46:15,995 --> 03:46:17,497 YEARS AGO. 4234 03:46:17,563 --> 03:46:18,031 THIS IS STILL WITH US. 4235 03:46:18,097 --> 03:46:22,769 THIS IS STILL WITH US. 4236 03:46:22,835 --> 03:46:25,672 ANYWAY, LET'S REVIEW THE 4237 03:46:25,738 --> 03:46:27,740 EVIDENCE. 4238 03:46:27,807 --> 03:46:31,044 THIS IS DONE BY NATIONAL 4239 03:46:31,110 --> 03:46:35,114 ACADEMIES OF SCIENCES WHO PUT 4240 03:46:35,181 --> 03:46:36,883 FORTH THIS HEFTY REPORT AND WHEN 4241 03:46:36,950 --> 03:46:38,117 THE COMMITTEE REVIEWED THE 4242 03:46:38,184 --> 03:46:40,086 EVIDENCE ISSUED THEIR 4243 03:46:40,153 --> 03:46:41,854 CONCLUSIONS, THESE WERE THEIR 4244 03:46:41,921 --> 03:46:42,588 CONCLUSIONS. 4245 03:46:42,655 --> 03:46:44,290 THE FIRST CONCLUSION IS I'LL 4246 03:46:44,357 --> 03:46:46,025 READ FOR YOU, THIS IS 4247 03:46:46,092 --> 03:46:48,561 SUBSTANTIAL EVIDENCE OF A 4248 03:46:48,628 --> 03:46:50,330 STATISTICAL ASSOCIATION BETWEEN 4249 03:46:50,396 --> 03:46:52,332 CANNABIS USE AND THE DEVELOPMENT 4250 03:46:52,398 --> 03:46:55,001 OF SCHIZOPHRENIA OR OTHER 4251 03:46:55,068 --> 03:46:58,838 PSYCHOSIS WITH THE HIGHEST RISK 4252 03:46:58,905 --> 03:47:00,740 AMONG THE HIGHEST USERS AND IT 4253 03:47:00,807 --> 03:47:03,710 WAS ACCURATE, SUBSTANTIAL NOTE 4254 03:47:03,776 --> 03:47:04,911 CONCLUSIVE. 4255 03:47:04,978 --> 03:47:09,015 STATISTICAL ASSOCIATION NOT 4256 03:47:09,082 --> 03:47:09,315 CAUSAL. 4257 03:47:09,382 --> 03:47:15,021 IT'S A CAREFUL STATEMENT AND THE 4258 03:47:15,088 --> 03:47:16,622 REASON IT WAS CAREFUL AND THERE 4259 03:47:16,689 --> 03:47:17,523 WERE DISCUSSION ON THIS BECAUSE 4260 03:47:17,590 --> 03:47:24,564 WHEN YOU LOOK AT THE DATA 4261 03:47:24,630 --> 03:47:25,965 CAREFULLY THINGS AND THERE'S 4262 03:47:26,032 --> 03:47:27,600 MODERATE EVIDENCE AMONG 4263 03:47:27,667 --> 03:47:29,335 INDIVIDUALS WITH PSYCHOTIC 4264 03:47:29,402 --> 03:47:31,604 DISORDERS THERE'S A STATISTICAL 4265 03:47:31,671 --> 03:47:34,540 ASSOCIATION BETWEEN A HISTORY OF 4266 03:47:34,607 --> 03:47:36,342 CANNABIS USE AND BETTER 4267 03:47:36,409 --> 03:47:41,814 COGNITIVE PERFORMANCE WHICH IS 4268 03:47:41,881 --> 03:47:43,483 SUGGESTIVE OF CAUSAL AND THOSE 4269 03:47:43,549 --> 03:47:46,619 WHO USE CANNABIS IT SOMEHOW 4270 03:47:46,686 --> 03:47:48,621 MAKES THEM FEEL IN SOME WAYS 4271 03:47:48,688 --> 03:47:48,855 BETTER. 4272 03:47:48,921 --> 03:47:50,323 I'M NOT PROPOSING THAT THEORY 4273 03:47:50,390 --> 03:47:52,058 BUT SAYING THERE'S ENOUGH IN THE 4274 03:47:52,125 --> 03:47:55,061 DATA TO SUGGEST IT WOULD BE MORE 4275 03:47:55,128 --> 03:47:56,896 COMPLEX THAN JUST CANNABIS MAKES 4276 03:47:56,963 --> 03:47:58,798 YOU CRAZY. 4277 03:47:58,865 --> 03:48:03,469 THE ISSUE OF CAUSALITY WAS 4278 03:48:03,536 --> 03:48:05,571 EXPLICITLY RAISED IN THE STUDY 4279 03:48:05,638 --> 03:48:07,006 PUBLISHED IN 2021 AND CAUSALITY 4280 03:48:07,073 --> 03:48:08,641 WAS AT THE CENTER OF THE PAPER 4281 03:48:08,708 --> 03:48:19,185 AND THIS IS A LONGITUDINAL 4282 03:48:21,821 --> 03:48:27,894 DISCORDANT PAPER AND IN THE 4283 03:48:27,960 --> 03:48:34,100 STUDY US OF 262 TWINS REPORTING 4284 03:48:34,167 --> 03:48:38,638 GREATER CANNABIS USE REPORTED 4285 03:48:38,704 --> 03:48:43,042 HIGHER LEVEL OF PSYCHOLOGY AND 4286 03:48:43,109 --> 03:48:45,711 POORER ECONOMIC OUTCOME AND IT 4287 03:48:45,778 --> 03:48:48,948 HAD BEEN SHOWN AND THIS IS THE 4288 03:48:49,015 --> 03:48:51,984 KICKER CANNABIS USE REMAINS 4289 03:48:52,051 --> 03:48:53,453 RELATED WITH SOCIAL OUTCOMES, 4290 03:48:53,519 --> 03:49:02,662 EDUCATION AND OCCUPATIONAL 4291 03:49:02,728 --> 03:49:04,831 OUTCOMES AND IN OTHER WORDS 4292 03:49:04,897 --> 03:49:07,366 CANNABIS USE ON THE PAPER 4293 03:49:07,433 --> 03:49:10,436 APPEARS TO BE CAUSATIVE FOR 4294 03:49:10,503 --> 03:49:14,974 NEGATIVE SOCIO ECONOMIC OUTCOMES 4295 03:49:15,041 --> 03:49:17,443 BUT NOT FOR LOWER I.Q. OR 4296 03:49:17,510 --> 03:49:19,812 SCHIZOPHRENIA AND THE PAPER HAS 4297 03:49:19,879 --> 03:49:22,648 BEEN CITED 38 TIMES SINCE 2021. 4298 03:49:22,715 --> 03:49:23,516 THAT'S NOT A LOT. 4299 03:49:23,583 --> 03:49:24,317 WHAT NEXT? 4300 03:49:24,383 --> 03:49:26,853 HOW DO WE ADDRESS THE LINK 4301 03:49:26,919 --> 03:49:28,221 BETWEEN CANNABIS AND 4302 03:49:28,287 --> 03:49:28,554 SCHIZOPHRENIA? 4303 03:49:28,621 --> 03:49:29,555 I THINK WE'RE IN A GREAT PLACE 4304 03:49:29,622 --> 03:49:32,592 TO DO THAT BECAUSE WE HAVE SEEN 4305 03:49:32,658 --> 03:49:35,561 ABCD AND ALL OF US. 4306 03:49:35,628 --> 03:49:38,698 WE CAN USE MENDELIAN 4307 03:49:38,764 --> 03:49:40,766 RANDOMIZATION ON THE LARGE HUMAN 4308 03:49:40,833 --> 03:49:42,001 COHORT AND ASK WHAT IS CAUSATIVE 4309 03:49:42,068 --> 03:49:46,772 AND WHAT IS NOT. 4310 03:49:46,839 --> 03:49:50,176 WE CANNOT DO THEM BECAUSE 4311 03:49:50,243 --> 03:49:51,344 SCHIZOPHRENIA IS SO COMPLEX WE 4312 03:49:51,410 --> 03:49:54,847 DON'T HAVE ANYTHING CLOSE TO A 4313 03:49:54,914 --> 03:49:55,948 MODEL THERE. 4314 03:49:56,015 --> 03:50:04,757 I'LL QUICKLY CONCLUDE AND GO 4315 03:50:04,824 --> 03:50:09,061 OVER MY SECOND CASE STUDY. 4316 03:50:09,128 --> 03:50:11,831 WHETHER CANNABIS IS A SAFE AND 4317 03:50:11,898 --> 03:50:13,566 EFFECTIVE ANALGESIC. 4318 03:50:13,633 --> 03:50:15,201 THE FACE THAT LAUNCHED A 4319 03:50:15,268 --> 03:50:20,840 THOUSAND SHIPS WAS THIS PAPER 4320 03:50:20,907 --> 03:50:23,142 PUBLISHED IN 2007. 4321 03:50:23,209 --> 03:50:26,479 WHAT THE PAPER SHOWED WAS THAT 4322 03:50:26,546 --> 03:50:27,980 SMOKING LOW LEVELS OF CANNABIS 4323 03:50:28,047 --> 03:50:32,451 IN A SMALL NUMBER OF PATIENTS 4324 03:50:32,518 --> 03:50:37,023 WITH HIV ASSOCIATED SENSORY 4325 03:50:37,089 --> 03:50:46,332 NEUROON -- NEUROPATHY HAD LOWER 4326 03:50:46,399 --> 03:50:48,668 PAIN AND THIS WAS BASED ON A 4327 03:50:48,734 --> 03:50:53,606 BACKGROUND CONTRARY TO THE 4328 03:50:53,673 --> 03:50:57,810 PREVIOUS ONE WAS THE FIRST THEY 4329 03:50:57,877 --> 03:51:08,120 FOUND EUROPEAN ACCOUNT AND 4330 03:51:08,187 --> 03:51:10,122 CANNABIS AS AN ANALGESIC AND 4331 03:51:10,189 --> 03:51:13,693 READ THE TEXT AND THERE WAS AN 4332 03:51:13,759 --> 03:51:19,332 APPENDIX TO THE PAPER AND THIS 4333 03:51:19,398 --> 03:51:29,942 COMMENTARY ON THE PHARMACOPEIA 4334 03:51:35,748 --> 03:51:38,951 AROUND I FOUND SECESSION OF PAIN 4335 03:51:39,018 --> 03:51:39,952 AND PLEASANT NUMBNESS IN THE 4336 03:51:40,019 --> 03:51:43,889 LIMBS AND GIDDINESS AND 4337 03:51:43,956 --> 03:51:46,926 IMPOSSIBILITY TO FOLLOW TRAIN OF 4338 03:51:46,993 --> 03:51:48,194 THOUGHT AND SLIGHT INCREASE IN 4339 03:51:48,261 --> 03:51:49,595 THE FORCE OF THE PULSE. 4340 03:51:49,662 --> 03:51:52,131 THIS IS AN ACCURATE DESCRIPTION 4341 03:51:52,198 --> 03:51:52,865 OF WHAT CANNABIS DOES. 4342 03:51:52,932 --> 03:51:55,935 VERY ACCURATE AND TELLS YOU WE 4343 03:51:56,002 --> 03:51:58,638 TO THINGS. 4344 03:51:58,704 --> 03:52:09,248 IN ALL THE WARNING PEOPLE ONLY 4345 03:52:12,718 --> 03:52:17,456 RATE CESSATIONAL PAIN AND THE 4346 03:52:17,523 --> 03:52:18,357 COMMITTEE OF THE NATIONAL 4347 03:52:18,424 --> 03:52:20,593 ACADEMIES ARRIVED TO THE 4348 03:52:20,660 --> 03:52:21,594 CONCLUSION THERE WAS SUBSTANTIAL 4349 03:52:21,661 --> 03:52:23,296 EVIDENCE CANNABIS IS AN 4350 03:52:23,362 --> 03:52:24,096 EFFECTIVE TREATMENT FOR CHRONIC 4351 03:52:24,163 --> 03:52:29,468 PAIN IN ADULTS AND THERE WAS 4352 03:52:29,535 --> 03:52:32,438 STRONG RATIONALE SO WHEN NON 4353 03:52:32,505 --> 03:52:33,873 HUMAN SCIENTISTS CONVENED THEY 4354 03:52:33,939 --> 03:52:41,614 BASICALLY ARRIVED TO THE SAME 4355 03:52:41,681 --> 03:52:50,923 CONCLUSION. 4356 03:52:50,990 --> 03:52:52,525 AND THEY LOOKED AT THE 4357 03:52:52,591 --> 03:52:55,027 CO-PRESSURE TEST ON HUMAN 4358 03:52:55,094 --> 03:52:58,097 VOLUNTEERS TO STUDY AND EXAMINE 4359 03:52:58,164 --> 03:53:00,533 WHETHER THC WAS ANALGESIC OR NOT 4360 03:53:00,599 --> 03:53:01,634 AND IT'S AN INTERESTING STUDY. 4361 03:53:01,701 --> 03:53:04,704 YOU CAN SEE THE RESULTS HERE. 4362 03:53:04,770 --> 03:53:06,305 BASICALLY THE CONCLUSION WAS 4363 03:53:06,372 --> 03:53:10,543 THAT IN BOTH MEN AND WOMEN THC 4364 03:53:10,609 --> 03:53:12,845 PRODUCED AN ANALGESIC EFFECT ON 4365 03:53:12,912 --> 03:53:20,286 PAIN SENSITIVITY AND PAIN 4366 03:53:20,353 --> 03:53:20,553 TOLERANCE. 4367 03:53:20,619 --> 03:53:22,788 SO, LEADS US TO CONCLUDE BOTH 4368 03:53:22,855 --> 03:53:25,691 HUMAN AND ANIMAL DATA SUPPORT 4369 03:53:25,758 --> 03:53:28,260 THE NOTION CANNABIS CAUSES 4370 03:53:28,327 --> 03:53:28,627 ANALGESIA. 4371 03:53:28,694 --> 03:53:30,296 I'M USING A WORD NOT IN THE 4372 03:53:30,363 --> 03:53:31,831 PAPER BUT I THINK YOU 4373 03:53:31,897 --> 03:53:32,131 UNDERSTAND. 4374 03:53:32,198 --> 03:53:33,666 SO WHAT NEXT AND HOW DO YOU 4375 03:53:33,733 --> 03:53:38,104 ADDRESS THE CAUSAL NATURE OF THE 4376 03:53:38,170 --> 03:53:43,576 LINK BETWEEN CANNABIS AND A 4377 03:53:43,642 --> 03:53:45,745 ANALGESIA AND IS IT SAFETY 4378 03:53:45,811 --> 03:53:48,347 ANDES 4379 03:53:48,414 --> 03:53:51,016 ANDESQUE -- SAFE AND EFFECTIVE 4380 03:53:51,083 --> 03:53:52,885 AS AN ANALGESIC AND LOOK AT 4381 03:53:52,952 --> 03:53:58,924 PLACEBO CONTROLS OF CP -- 4382 03:53:58,991 --> 03:54:03,028 CHRONIC PAINS IN ADULTS AND WE 4383 03:54:03,095 --> 03:54:05,965 CAN HAVE HUMAN TRIALS TO AID US 4384 03:54:06,031 --> 03:54:09,702 IN THE SELECTION OF ONE OR MORE 4385 03:54:09,769 --> 03:54:11,103 SUITABLE CHRONIC PAIN CONDITIONS 4386 03:54:11,170 --> 03:54:13,139 BECAUSE CHRONIC PAIN IS A 4387 03:54:13,205 --> 03:54:15,040 HETEROGENOUS CONSTRUCT AND 4388 03:54:15,107 --> 03:54:16,108 CONTAINS MANY THINGS. 4389 03:54:16,175 --> 03:54:22,181 I'LL START BY SUGGESTING YOU 4390 03:54:22,248 --> 03:54:23,649 DOWNLOAD THIS AND IT'S 486 4391 03:54:23,716 --> 03:54:28,421 PANELS PAGES BUT IT'S USEFUL 4392 03:54:28,487 --> 03:54:31,157 FOR A VARIETY OF THINGS. 4393 03:54:31,223 --> 03:54:32,992 UNFORTUNATELY IT'S STILL 4394 03:54:33,058 --> 03:54:33,793 UPDATED. 4395 03:54:33,859 --> 03:54:36,195 I WISH I COULD SAY IN FOUR OR 4396 03:54:36,262 --> 03:54:41,634 SIX YEARS OR WHATEVER AND FIVE 4397 03:54:41,700 --> 03:54:44,570 YEARS WHATEVER. 4398 03:54:44,637 --> 03:54:46,205 WE HAVE SO MANY MORE DATA IT'S 4399 03:54:46,272 --> 03:54:49,575 STILL QUITE UPDATED AND WITH 4400 03:54:49,642 --> 03:54:56,849 THAT I'LL STOP AND THANK YOU. 4401 03:54:56,916 --> 03:55:07,460 >> THANK YOU, PIOMELLI FOR THE 4402 03:55:09,728 --> 03:55:10,029 PROVOCATIVE TALK. 4403 03:55:10,095 --> 03:55:10,796 WE HAVE TIME FOR THREE OR FOUR 4404 03:55:10,863 --> 03:55:21,040 QUESTIONS. 4405 03:55:43,429 --> 03:55:45,931 >> I LOVED THE COMMENT ABOUT 4406 03:55:45,998 --> 03:55:52,037 DON'T LET THE MARKETERS USE THE 4407 03:55:52,104 --> 03:55:56,442 VOCABULARY AND I HATE SOME THAT 4408 03:55:56,509 --> 03:55:56,942 POP UP. 4409 03:55:57,009 --> 03:56:00,679 SECOND I WOULD ADD THAT TO YOUR 4410 03:56:00,746 --> 03:56:04,416 LIST OF THINGS NOT TO USE. 4411 03:56:04,483 --> 03:56:06,418 >> PEOPLE DO WHAT PEOPLE DO. 4412 03:56:06,485 --> 03:56:13,726 ALL WE CAN DO IS MAKE 4413 03:56:13,792 --> 03:56:20,065 SUGGESTIONS. 4414 03:56:20,132 --> 03:56:22,968 >> SO, I APPRECIATE THE FACT YOU 4415 03:56:23,035 --> 03:56:24,637 SAID THIS IS A CANNABIS ISSUE 4416 03:56:24,703 --> 03:56:26,472 BUT I'M THINKING THE BRAIN 4417 03:56:26,539 --> 03:56:31,277 DOESN'T KNOW WHETHER THE DRUG IS 4418 03:56:31,343 --> 03:56:34,380 ELICIT OR LEGAL AND IT'S 4419 03:56:34,446 --> 03:56:37,650 BIOLOGICAL AND CAN WE EXTRACT 4420 03:56:37,716 --> 03:56:39,485 FROM CANNABIS OTHER DRUGS OF 4421 03:56:39,552 --> 03:56:41,353 ABUSE AND THINKING THE OPIOID 4422 03:56:41,420 --> 03:56:43,589 PROCESS IS A RELATIVELY 4423 03:56:43,656 --> 03:56:45,624 EFFECTIVE ANALGESIC BUT HAS 4424 03:56:45,691 --> 03:56:46,292 RESPIRATORY DEPRESSION AND HIGH 4425 03:56:46,358 --> 03:56:51,497 RISK FOR OVERDOSE AND DEATH AND 4426 03:56:51,564 --> 03:56:51,764 ABUSE. 4427 03:56:51,830 --> 03:56:54,199 SO, TRYING TO GET AT THE SENSE 4428 03:56:54,266 --> 03:56:56,635 OF RISK BENEFIT HERE REGARDLESS 4429 03:56:56,702 --> 03:57:01,206 OF TALKING ABOUT CANNABIS OR ANY 4430 03:57:01,273 --> 03:57:02,341 PHARMACEUTICAL AT THIS POINT OR 4431 03:57:02,408 --> 03:57:03,242 CAN YOU EXTRACT WHAT YOU'RE 4432 03:57:03,309 --> 03:57:05,811 SAYING TO OTHER DRUGS OF ABUSE? 4433 03:57:05,878 --> 03:57:08,714 >> I THINK WE CAN LOOK AT DRUGS 4434 03:57:08,781 --> 03:57:12,751 AS CULTURAL PHENOMENA AND I 4435 03:57:12,818 --> 03:57:13,886 THINK WE SHOULD. 4436 03:57:13,953 --> 03:57:15,754 IT'S COMPLEX BUT EVERY DRUG HAS 4437 03:57:15,821 --> 03:57:21,093 TO BE TREATED DIFFERENTLY AND 4438 03:57:21,160 --> 03:57:22,795 THERE'S A CASE IN THE GOOD AND 4439 03:57:22,861 --> 03:57:25,631 BAD BECAUSE WE HAVE SHAPED OUR 4440 03:57:25,698 --> 03:57:28,167 VIEW OF AN ANALGESIC BASED ON 4441 03:57:28,233 --> 03:57:28,801 THE OPIOIDS. 4442 03:57:28,867 --> 03:57:32,237 WHEN WE LOOK FOR A NEW ANALGESIC 4443 03:57:32,304 --> 03:57:33,272 WE LOOK FOR SOMETHING THAT DOES 4444 03:57:33,339 --> 03:57:35,808 WHAT THE OPIOIDS DO BUT THEY'RE 4445 03:57:35,874 --> 03:57:40,012 VERY PECULIAR IN THE WAY THEY 4446 03:57:40,079 --> 03:57:42,915 PRODUCE ANALGESIA AND LIKEWISE 4447 03:57:42,982 --> 03:57:45,551 WE'RE SHAPED TO HAVE NEGATIVE 4448 03:57:45,618 --> 03:57:46,518 VIEWS BASED ON OPIOIDS BECAUSE 4449 03:57:46,585 --> 03:57:49,955 OF CULTURAL FACTORS. 4450 03:57:50,022 --> 03:57:53,626 AND THERE'S HIGHLY ADDICTIVE 4451 03:57:53,692 --> 03:57:54,159 DRUGS AND CAN KILL PEOPLE. 4452 03:57:54,226 --> 03:57:58,797 HAVING A CONVERSATION ABOUT THE 4453 03:57:58,864 --> 03:58:00,165 CULTURAL SIGNIFICANCE OF DRUGS 4454 03:58:00,232 --> 03:58:01,467 AND THIS HAPPENED FOR EXAMPLE 4455 03:58:01,533 --> 03:58:04,837 WITH PROZAC MANY YEARS AGO. 4456 03:58:04,903 --> 03:58:07,272 WE AS SCIENTISTS SHOULD BE 4457 03:58:07,339 --> 03:58:07,873 SOMETIMES PART OF THE 4458 03:58:07,940 --> 03:58:09,708 CONVERSATION THOUGH OF COURSE IT 4459 03:58:09,775 --> 03:58:11,210 BECOMES QUICKLY SOMETHING WE 4460 03:58:11,276 --> 03:58:13,479 DON'T FEEL COMFORTABLE WITH 4461 03:58:13,545 --> 03:58:15,047 BECAUSE IT DOESN'T HAVE DATA 4462 03:58:15,114 --> 03:58:15,581 MORE INTERPRETATION AND 4463 03:58:15,648 --> 03:58:18,283 ITERATION OF THE DATA BUT I FEEL 4464 03:58:18,350 --> 03:58:28,894 IT'S ALSO IMPORTANT TO CONSIDER. 4465 03:58:31,930 --> 03:58:37,670 >> MY PRESENTATION WAS VERY 4466 03:58:37,736 --> 03:58:47,913 [OFF-MIC] 4467 03:58:59,591 --> 03:59:01,727 >> THE QUESTION IS DO YOU THINK 4468 03:59:01,794 --> 03:59:05,698 THERE IS A REASON TO STUDY 4469 03:59:05,764 --> 03:59:07,666 CANNABIS USE IN HEALTHY 4470 03:59:07,733 --> 03:59:09,368 INDIVIDUALS AND IMPACT ON THEIR 4471 03:59:09,435 --> 03:59:11,770 HEALTH RATHER THAN JUST HOW TO 4472 03:59:11,837 --> 03:59:16,141 MITIGATE SOME DISEASE? 4473 03:59:16,208 --> 03:59:17,509 >> EXCELLENT QUESTION AND HOW 4474 03:59:17,576 --> 03:59:22,214 HEALTHY IS A HEALTHY INDIVIDUAL? 4475 03:59:22,281 --> 03:59:27,186 ONE DEMOGRAPHIC HAS SEEN IN 4476 03:59:27,252 --> 03:59:30,689 RECENT YEARS AN INCREASE IN 4477 03:59:30,756 --> 03:59:33,659 CANNABIS USE AND THAT'S MY 4478 03:59:33,726 --> 03:59:36,729 DEMOGRAPHIC 55 YEARS AND OLDER 4479 03:59:36,795 --> 03:59:38,263 BUT MY DEMOGRAPHIC HAS INCREASED 4480 03:59:38,330 --> 03:59:40,232 AND WHY IS THAT SO? 4481 03:59:40,299 --> 03:59:42,968 PEOPLE HAVE DONE SURVEYS AND 4482 03:59:43,035 --> 03:59:45,704 FIND CANNABIS IS USED IN MY AGE 4483 03:59:45,771 --> 03:59:53,812 GROUP TO BASICALLY ALLEVIATE 4484 03:59:53,879 --> 03:59:59,685 LITTLE PAINS OR FACILITATE 4485 03:59:59,752 --> 04:00:00,586 SLEEP. 4486 04:00:00,652 --> 04:00:02,521 THE HEALTH CHANGES OUR 4487 04:00:02,588 --> 04:00:05,691 PERCEPTION AND HEALTH CHANGES 4488 04:00:05,758 --> 04:00:09,061 OVER TIME AND CANNABIS NOT JUST 4489 04:00:09,128 --> 04:00:11,964 CANNABIS ANY OTHER RECREATIONAL 4490 04:00:12,030 --> 04:00:13,365 SUBSTANCE INCLUDING ALCOHOL AND 4491 04:00:13,432 --> 04:00:15,868 COFFEE ARE USED IN THE CONTEXT. 4492 04:00:15,934 --> 04:00:21,340 YEAH, I USE COFFEE DAILY BUT I 4493 04:00:21,406 --> 04:00:23,675 UNDERSTAND WHY SOMEONE WOULD 4494 04:00:23,742 --> 04:00:26,111 SAY, OKAY, LOOK, IF I SMOKE A 4495 04:00:26,178 --> 04:00:27,980 JOINT IF I'M GOING TO BED I'M 4496 04:00:28,046 --> 04:00:30,082 GOING TO SLEEP BETTER OR TAKE AN 4497 04:00:30,149 --> 04:00:30,315 EDIBLE. 4498 04:00:30,382 --> 04:00:31,517 I UNDERSTAND THAT. 4499 04:00:31,583 --> 04:00:34,453 OF COURSE WHAT I LIKE TO SEE THE 4500 04:00:34,520 --> 04:00:37,623 DATA SHOWING THAT IS BACKED BY 4501 04:00:37,689 --> 04:00:38,757 EMPIRICAL EVIDENCE? 4502 04:00:38,824 --> 04:00:41,160 YES, I WOULD, OF COURSE. 4503 04:00:41,226 --> 04:00:51,737 BUT IT'S A DIFFERENT BALLPARK. 4504 04:00:53,539 --> 04:00:54,072 >> OKAY. 4505 04:00:54,139 --> 04:00:56,074 THE OTHER THING WE'RE NOT 4506 04:00:56,141 --> 04:00:57,142 TALKING ABOUT AS A 4507 04:00:57,209 --> 04:00:58,410 PHARMACOLOGIST IT'S ALL ABOUT 4508 04:00:58,477 --> 04:01:00,312 CONCENTRATION AND CONCENTRATION. 4509 04:01:00,379 --> 04:01:04,683 THE DATA WAS WITH 5% TO 7% BY 4510 04:01:04,750 --> 04:01:05,417 WEIGHT THC. 4511 04:01:05,484 --> 04:01:07,386 HOW MUCH DO WE REQUIRE WHEN WE 4512 04:01:07,452 --> 04:01:09,254 HAVE PLANT MATERIAL KNOW THAT'S 4513 04:01:09,321 --> 04:01:12,524 30%, 35% OF EXTRACTS PUSHING 4514 04:01:12,591 --> 04:01:13,258 100? 4515 04:01:13,325 --> 04:01:15,027 WE DON'T TALK ABOUT THAT OTHER. 4516 04:01:15,093 --> 04:01:16,261 STUDIES THAT SAY WHEN THE FDA 4517 04:01:16,328 --> 04:01:21,066 APPROVES A DRUG YOU VA -- HAVE 4518 04:01:21,133 --> 04:01:22,734 TO SHOW A DOSE RESPONSE CURVE IN 4519 04:01:22,801 --> 04:01:24,736 THE DATA AND WE DON'T EVEN 4520 04:01:24,803 --> 04:01:25,337 CONSIDER IT. 4521 04:01:25,404 --> 04:01:26,338 >> IT'S VERY HARD. 4522 04:01:26,405 --> 04:01:29,708 THIS IS IN ITSELF A TOPIC FOR A 4523 04:01:29,775 --> 04:01:30,309 SEPARATE CONVERSATION. 4524 04:01:30,375 --> 04:01:33,712 I CAN'T DEVELOP THAT BUT IT'S 4525 04:01:33,779 --> 04:01:37,783 TRULY A VERY HARD PROBLEM 4526 04:01:37,850 --> 04:01:44,156 BECAUSE AND WE'RE DEALING WITH 4527 04:01:44,223 --> 04:01:47,860 THE PROBLEM OF HIGH POTENCY 4528 04:01:47,926 --> 04:01:49,928 CANNABIS PRODUCTS. 4529 04:01:49,995 --> 04:01:54,733 AND EVEN DEFINING HIGH POTENCY 4530 04:01:54,800 --> 04:01:56,568 IS AN EXAMPLE. 4531 04:01:56,635 --> 04:02:00,639 SAY WE'RE LOOKING AT A FLOWER 4532 04:02:00,706 --> 04:02:03,942 THAT CONVEYS 26% THC IS AVERAGE 4533 04:02:04,009 --> 04:02:04,142 NOW. 4534 04:02:04,209 --> 04:02:05,711 LET'S LOOK AT THAT. 4535 04:02:05,777 --> 04:02:09,214 THE QUESTION IS HOW MUCH OF THAT 4536 04:02:09,514 --> 04:02:10,983 26% WILL GO IN THE PERSON? 4537 04:02:11,049 --> 04:02:13,619 HOW MUCH IS THE REAL DOSE. 4538 04:02:13,685 --> 04:02:21,460 DOES THE PERSON TITRATE OR NOT? 4539 04:02:21,526 --> 04:02:25,163 I HAVE NOT SEEN DATA SHOWING 4540 04:02:25,230 --> 04:02:26,465 TITRATION OR NOT. 4541 04:02:26,531 --> 04:02:28,500 MAYBE IN COLORADO THERE WAS A 4542 04:02:28,567 --> 04:02:31,270 STUDY AND I DON'T KNOW IF THEY 4543 04:02:31,336 --> 04:02:35,007 CAN ILLUMINATE US BUT IT'S A 4544 04:02:35,073 --> 04:02:39,244 STEP WISE APPROACH. 4545 04:02:39,311 --> 04:02:41,947 SO HOW MUCH THC DO PEOPLE 4546 04:02:42,014 --> 04:02:44,549 ACTUALLY USE? 4547 04:02:44,616 --> 04:02:46,485 AFTER THAT, THEN I THINK POLICY 4548 04:02:46,551 --> 04:02:51,723 DECISIONS CAN BE MADE AS TO 4549 04:02:51,790 --> 04:02:53,525 WHETHER FOR EXAMPLE TAX HIGH THC 4550 04:02:53,592 --> 04:02:56,929 PRODUCTS OR NOT. 4551 04:02:56,995 --> 04:02:57,496 >> GREAT TALK. 4552 04:02:57,562 --> 04:03:02,634 YOU STARTED BY SAYING THAT WE 4553 04:03:02,701 --> 04:03:12,945 ARE HERE BECAUSE OF THC. 4554 04:03:13,011 --> 04:03:17,416 FOR THE FIRST HALF OF THE DAY WE 4555 04:03:17,482 --> 04:03:18,951 WERE TALKING SPECIFICALLY ABOUT 4556 04:03:19,017 --> 04:03:24,189 CANNABIS CONSTITUENTS NOT THC. 4557 04:03:24,256 --> 04:03:30,729 YOU SKIRTED AROUND THE TOPIC OF 4558 04:03:30,796 --> 04:03:33,165 OTHER CONSTITUENTS MAY OR MAY 4559 04:03:33,231 --> 04:03:34,866 NOT BE AND HOW IT'S SHAPING THE 4560 04:03:34,933 --> 04:03:35,500 CULTURAL CONVERSATION IN THE 4561 04:03:35,567 --> 04:03:36,268 UNITED STATES WHERE THERE'S A 4562 04:03:36,335 --> 04:03:37,569 VARIETY OF PRODUCTS AVAILABLE 4563 04:03:37,636 --> 04:03:39,004 THAT ARE NOT THC. 4564 04:03:39,071 --> 04:03:41,873 I'M WONDERING IF YOU CAN THINK 4565 04:03:41,940 --> 04:03:43,575 ABOUT WHAT WILL HAPPEN IN THE 4566 04:03:43,642 --> 04:03:53,719 NEXT 10 YEARS WILL THE 4567 04:03:53,785 --> 04:03:59,024 CONVERSATION TO CONSTITUENTS 4568 04:03:59,091 --> 04:04:00,092 SHIFT OR THINK IT'S THC? 4569 04:04:00,158 --> 04:04:04,229 >> IF YOU'RE THINKING ABOUT WHY 4570 04:04:04,296 --> 04:04:10,769 MOST PEOPLE WE KNOW, OUR TEENAGE 4571 04:04:10,836 --> 04:04:15,207 KIDS OR MY 70-YEAR-OLD NEIGHBOR 4572 04:04:15,273 --> 04:04:17,275 USE CANNABIS BECAUSE IT HAS THC 4573 04:04:17,342 --> 04:04:19,978 MY ANSWER IS WELL 90% OF THE 4574 04:04:20,045 --> 04:04:22,481 CASES IT'S BECAUSE OF THC. 4575 04:04:22,547 --> 04:04:24,483 THE KNOWN MEDICAL USE REQUIRES 4576 04:04:24,549 --> 04:04:30,555 THC OTHERWISE WHY WOULD YOU EVEN 4577 04:04:30,622 --> 04:04:33,725 DO IT AND IT'S NOT PROVIDING YOU 4578 04:04:33,792 --> 04:04:35,627 THE EUPHORIA AND FEELING OF 4579 04:04:35,694 --> 04:04:39,531 RELAXATION AND THE CHANGES AND 4580 04:04:39,598 --> 04:04:42,401 SENSES AND THE INCREASED SENSORY 4581 04:04:42,467 --> 04:04:46,605 EXPERIENCE THAT THC PROVIDES. 4582 04:04:46,671 --> 04:04:48,140 THAT FEELS GOOD JUST LIKE A 4583 04:04:48,206 --> 04:04:50,809 GLASS OF RED WINE FEELS GOOD. 4584 04:04:50,876 --> 04:04:52,878 THAT IS THC. 4585 04:04:52,944 --> 04:04:54,179 NOW WHAT HAPPENED WITH CANNABIS 4586 04:04:54,246 --> 04:04:59,684 WHICH I FEEL IS GREAT, THE 4587 04:04:59,751 --> 04:05:00,986 CORRELATES OF THAT THANKS TO 4588 04:05:01,053 --> 04:05:03,121 CANNABIS WE'RE DOING TWO THINGS. 4589 04:05:03,188 --> 04:05:06,725 FIRST IS WE HAVE AN 4590 04:05:06,792 --> 04:05:07,359 ENDOCANNABINOID SYSTEM IN THE 4591 04:05:07,426 --> 04:05:08,894 BRAIN AND HAD NO IDEA ABOUT THAT 4592 04:05:08,960 --> 04:05:10,896 25 YEARS AGO AND THAT'S A MAJOR 4593 04:05:10,962 --> 04:05:12,931 THING SO IF ANYTHING WE SHOULD 4594 04:05:12,998 --> 04:05:16,034 BE GRATEFUL BECAUSE THE 4595 04:05:16,101 --> 04:05:18,103 DISCOVERY IN THE BRAIN AND, 4596 04:05:18,170 --> 04:05:21,640 SECOND, CANNABIS ITSELF IS A 4597 04:05:21,706 --> 04:05:22,307 FANTASTIC PLANT. 4598 04:05:22,374 --> 04:05:26,344 IT'S A CHEMICAL FACTORY. 4599 04:05:26,411 --> 04:05:28,313 IF YOU LOOK AT THE TERPENE AND 4600 04:05:28,380 --> 04:05:29,981 THE VARIOUS REACTION THAT 4601 04:05:30,048 --> 04:05:32,217 FOLLOWS YOU HAVE 140, 150 4602 04:05:32,284 --> 04:05:34,586 MOLECULES THERE THAT ARE BASED 4603 04:05:34,653 --> 04:05:41,726 ON A SCAFFOLD THAT IS WHAT US IN 4604 04:05:41,793 --> 04:05:45,363 DRUG DISCOVERY WE CALL IT A 4605 04:05:45,430 --> 04:05:46,465 PREFERRED SCAFFOLD. 4606 04:05:46,531 --> 04:05:46,998 IT'S EFFICACIOUS BUT NOT 4607 04:05:47,065 --> 04:05:52,104 PARTICULARLY TOXIC. 4608 04:05:52,170 --> 04:05:53,572 THAT IS WHERE ALL OF YOU GUYS 4609 04:05:53,638 --> 04:05:54,973 WERE TODAY. 4610 04:05:55,040 --> 04:05:56,641 NOT ME, I DON'T DO THAT A LOT 4611 04:05:56,708 --> 04:06:00,545 BUT ALL YOU GUYS TODAY CAN HELP. 4612 04:06:00,612 --> 04:06:03,849 IF THAT SCAFFOLD IS PROMISING AS 4613 04:06:03,915 --> 04:06:05,584 I THINK IT IS, STUFF WILL COME 4614 04:06:05,650 --> 04:06:09,621 UP THAT HAS NOTHING TO DO WITH 4615 04:06:09,688 --> 04:06:10,188 CANNABIS. 4616 04:06:10,255 --> 04:06:12,224 LET'S FACE IT IT BARELY LOOKS 4617 04:06:12,290 --> 04:06:13,959 LIKE THC. 4618 04:06:14,025 --> 04:06:16,428 IT LOOKS MORE LIKE ANOTHER 4619 04:06:16,495 --> 04:06:17,729 TERPENE BUT COULD HAVE AN 4620 04:06:17,796 --> 04:06:19,698 INTERESTING SERIES OF EFFECTS 4621 04:06:19,764 --> 04:06:22,367 AND CANNOT BE VARYING AND ALL 4622 04:06:22,434 --> 04:06:23,568 THE DIFFERENT KIND. 4623 04:06:23,635 --> 04:06:26,805 IF WE LOOK AT THEM AND LOOK AT 4624 04:06:26,872 --> 04:06:28,406 CANNABIS AS A CHEMICAL PLANT IN 4625 04:06:28,473 --> 04:06:32,277 THE NOT SENSE OF VEGETABLE, THE 4626 04:06:32,344 --> 04:06:38,783 SENSE OF CHEMICAL PLANT, THEN WE 4627 04:06:38,850 --> 04:06:46,525 JUST USE IT TO CREATE NEW 4628 04:06:46,591 --> 04:06:47,859 MEDICATIONS AND IT'S 4629 04:06:47,926 --> 04:06:49,694 HAPPENSTANCE AS A LUCKY 4630 04:06:49,761 --> 04:06:50,195 DISCOVERY. 4631 04:06:50,262 --> 04:06:51,530 THAT'S ALL I CAN SAY. 4632 04:06:51,596 --> 04:06:58,970 THANK YOU SO MUCH. 4633 04:06:59,037 --> 04:07:02,774 >> THANK YOU SO MUCH FOR THE 4634 04:07:02,841 --> 04:07:05,510 KEYNOTE DR. PIOMELLI AND FOR 4635 04:07:05,577 --> 04:07:07,679 LEADING THE SESSION. 4636 04:07:07,746 --> 04:07:10,282 NOW, WE ARE STARTING OUR FOURTH 4637 04:07:10,348 --> 04:07:14,419 SESSION WITH THE MODERATOR THE 4638 04:07:14,486 --> 04:07:17,923 DEPUTY DIRECTOR OFF THE DIVISION 4639 04:07:17,989 --> 04:07:19,991 FOR EXTRAMURAL RESEARCH 4640 04:07:20,058 --> 04:07:22,227 DR. CRAIG HOPP ON THE KNEW 4641 04:07:22,294 --> 04:07:23,428 INITIATIVES AND RESOURCES FOR 4642 04:07:23,495 --> 04:07:23,995 CANNABIS RESEARCH. 4643 04:07:24,062 --> 04:07:25,497 >> THANK YOU FOR THE 4644 04:07:25,564 --> 04:07:26,498 INTRODUCTION, INNA. 4645 04:07:26,565 --> 04:07:28,466 WE'RE GOING TO TALK NOW FOR THE 4646 04:07:28,533 --> 04:07:30,835 NEXT HOUR OR SO ABOUT OR HALF 4647 04:07:30,902 --> 04:07:34,105 OUR ABOUT SOME OF THE NEW THINGS 4648 04:07:34,172 --> 04:07:37,842 GOING ON AND START OFF WITH ONE 4649 04:07:37,909 --> 04:07:39,844 OF MY CLOSE COLLEAGUES AND 4650 04:07:39,911 --> 04:07:42,614 FELLOW NATURAL PRODUCTS CHEMIST 4651 04:07:42,681 --> 04:07:46,151 DR. PATRICK STILL TO TALK ABOUT 4652 04:07:46,218 --> 04:07:51,623 A NEW INITIATIVE I THINK DAVID 4653 04:07:51,690 --> 04:07:52,257 REFERENCED THE CANNABIS RESOURCE 4654 04:07:52,324 --> 04:07:53,358 CENTER AND TELL US WHAT THAT 4655 04:07:53,425 --> 04:08:03,902 WILL PROVIDE FOR EVERYBODY. 4656 04:08:21,319 --> 04:08:22,520 >> GOOD AFTERNOON, EVERYONE. 4657 04:08:22,587 --> 04:08:25,724 SO I'M NOT SURE IF THE SLIDE SET 4658 04:08:25,790 --> 04:08:36,201 IS ON ITS WAY UP OR -- 4659 04:10:23,942 --> 04:10:26,211 >> APOLOGIES FOR THE TECHNICAL 4660 04:10:26,277 --> 04:10:27,579 DIFFICULTY WE'LL DO IT VERBALLY 4661 04:10:27,645 --> 04:10:28,446 IN THE INTEREST OF TIME. 4662 04:10:28,513 --> 04:10:29,647 GOOD AFTERNOON, EVERYONE. 4663 04:10:29,714 --> 04:10:31,583 MY NAME IS PATRICK STILL. 4664 04:10:31,649 --> 04:10:33,718 I'M A PROGRAM DIRECTOR AT THE 4665 04:10:33,785 --> 04:10:37,188 BASIC AND MECHANISTIC BRANCH 4666 04:10:37,255 --> 04:10:38,990 HERE AT NCCIH AND I ADMINISTER 4667 04:10:39,057 --> 04:10:41,993 A 4668 04:10:42,060 --> 04:10:43,194 PORTFOLIO ON PART OF OUR NATURAL 4669 04:10:43,261 --> 04:10:47,599 PRODUCT AREAS WE COVER. 4670 04:10:47,665 --> 04:10:49,100 AND I WANT TO THANK EVERYONE 4671 04:10:49,167 --> 04:10:52,971 VIRTUALLY AND IN PERSON FOR 4672 04:10:53,037 --> 04:10:54,472 ATTENDING AND WE'RE EXCITED DO 4673 04:10:54,539 --> 04:10:55,607 HAVE YOU HERE. 4674 04:10:55,673 --> 04:11:01,613 I'LL BE DISCUSSING AN RFA THAT 4675 04:11:01,679 --> 04:11:03,915 WAS PUBLISHED JUST LAST OCTOBER 4676 04:11:03,982 --> 04:11:06,317 FOR A RESOURCE CENTER FOR 4677 04:11:06,384 --> 04:11:09,120 CANNABIS AND CANNABINOID 4678 04:11:09,187 --> 04:11:10,221 RESEARCH. 4679 04:11:10,288 --> 04:11:13,425 AND THIS WAS LED BY NCCIH IN 4680 04:11:13,491 --> 04:11:17,595 PARTNERSHIP WITH NIDA, NIA AND 4681 04:11:17,662 --> 04:11:20,131 NCI AND WALK YOU THROUGH 4682 04:11:20,198 --> 04:11:20,899 VERBALLY IN THE ABSENCE OF OUR 4683 04:11:20,965 --> 04:11:23,768 SLIDES THIS AFTERNOON. 4684 04:11:23,835 --> 04:11:25,036 WE KNOW THAT CANNABIS AND ITS 4685 04:11:25,103 --> 04:11:27,038 CONSTITUENTS HAVE A WIDE VARIETY 4686 04:11:27,105 --> 04:11:30,275 OF PHARMACOLOGIC EFFECTS AND THE 4687 04:11:30,341 --> 04:11:32,811 PUBLIC POLICY AND LEGALIZATION 4688 04:11:32,877 --> 04:11:34,679 LANDSCAPE HAS BEEN CHANGING 4689 04:11:34,746 --> 04:11:37,715 QUITE RAPIDLY AND DESPITE THIS 4690 04:11:37,782 --> 04:11:40,318 WIDESPREAD AVAILABILITY OF 4691 04:11:40,385 --> 04:11:42,420 VARIOUS CANNABIS PRODUCTS AND 4692 04:11:42,487 --> 04:11:43,888 ESTABLISHED PHARMACEUTICAL 4693 04:11:43,955 --> 04:11:46,257 POTENTIAL THERE'S STILL 4694 04:11:46,324 --> 04:11:49,694 SIGNIFICANT BARRIERS TO 4695 04:11:49,761 --> 04:11:51,062 CONDUCTING RESEARCH IN THE AREA. 4696 04:11:51,129 --> 04:11:51,830 THE PURPOSE OF THE RESOURCE 4697 04:11:51,896 --> 04:12:02,407 CENTER YOU SEE IN YOUR AGENDA. 4698 04:12:55,293 --> 04:12:57,595 THE PURPOSE OF THE PROPOSED 4699 04:12:57,662 --> 04:12:58,897 RESOURCE CENTER AND THE TO BE 4700 04:12:58,963 --> 04:13:00,265 FUNDED RESOURCE CENTER WOULD BE 4701 04:13:00,331 --> 04:13:05,703 TO ADDRESS BARRIERS TO 4702 04:13:05,770 --> 04:13:11,809 CONDUCTING RESEARCH IN THE FIELD 4703 04:13:11,876 --> 04:13:14,145 OF CANNABIS AND GENERATE DATA 4704 04:13:14,212 --> 04:13:15,313 ACROSS THE DOMAINS DISCUSSED 4705 04:13:15,380 --> 04:13:19,851 TODAY BASIC AND CLINICAL. 4706 04:13:19,918 --> 04:13:24,389 SO OVER THE PAST SEVERAL YEARS 4707 04:13:24,455 --> 04:13:25,657 NCCIH AND OTHER PARTNER 4708 04:13:25,723 --> 04:13:28,326 INSTITUTIONS HAVE ORGANIZED A 4709 04:13:28,393 --> 04:13:30,228 VARIETY OF PRINCIPLE 4710 04:13:30,295 --> 04:13:31,796 INVESTIGATOR MEETINGS LIKE THE 4711 04:13:31,863 --> 04:13:33,865 ONES WE'RE HERE FOR TODAY AND 4712 04:13:33,932 --> 04:13:35,533 THERE'S BEEN HIGHLIGHTED 4713 04:13:35,600 --> 04:13:37,201 BARRIERS AND CHALLENGES TO 4714 04:13:37,268 --> 04:13:43,741 RESEARCH IN THIS FIELD AND IN 4715 04:13:43,808 --> 04:13:46,144 2022, NCCIH ISSUED A REQUEST FOR 4716 04:13:46,210 --> 04:13:49,914 INFORMATION TO SOLICIT THE 4717 04:13:49,981 --> 04:13:51,849 COMMUNITY TO IDENTIFY BARRIERS 4718 04:13:51,916 --> 04:13:53,051 IN RESEARCH OF THE FIELD AND THE 4719 04:13:53,117 --> 04:13:59,624 RESULT OF THE RFI WERE SCHEDULE 4720 04:13:59,691 --> 04:14:01,693 1 STATUS AND CHALLENGES IN 4721 04:14:01,759 --> 04:14:05,630 OBTAINING AND MAINTAINING 4722 04:14:05,697 --> 04:14:14,238 LICENSING AS WELL AS ISSUES FOR 4723 04:14:14,305 --> 04:14:15,974 INDs AND CHALLENGES. 4724 04:14:16,040 --> 04:14:18,242 TO ADDRESS THE CHALLENGES WE 4725 04:14:18,309 --> 04:14:20,778 ISSUED THE RFA FOR THE RESOURCE 4726 04:14:20,845 --> 04:14:21,312 CENTER. 4727 04:14:21,379 --> 04:14:22,847 AND SO THE SERVICES THAT ARE TO 4728 04:14:22,914 --> 04:14:26,084 BE PROVIDED BY THIS AND HOW IT 4729 04:14:26,150 --> 04:14:28,119 WOULD HELP THE COMMUNITY ARE 4730 04:14:28,186 --> 04:14:29,687 ENVISIONED IN THREE CORE 4731 04:14:29,754 --> 04:14:30,755 COMPONENTS THAT APPLICATIONS 4732 04:14:30,822 --> 04:14:33,224 THAT ARE APPLY TO THIS 4733 04:14:33,291 --> 04:14:34,592 INITIATIVE HAD TO HAVE INCLUDING 4734 04:14:34,659 --> 04:14:37,128 THE REGULATORY GUIDANCE CORPS, 4735 04:14:37,195 --> 04:14:38,463 RESEARCH STANDARDS CORPS AND 4736 04:14:38,529 --> 04:14:45,536 RESEARCH SUPPORT CORPS. 4737 04:14:45,603 --> 04:14:48,940 THE REGULATORY GUIDANCE CORE IS 4738 04:14:49,007 --> 04:14:53,711 TO LINK TO EXISTING FDA GUIDANCE 4739 04:14:53,778 --> 04:14:55,213 FOR EXAMPLE. 4740 04:14:55,279 --> 04:14:59,784 RESEARCH STANDARD CORPS WOULD 4741 04:14:59,851 --> 04:15:00,618 PROVIDE FOR STANDARDS 4742 04:15:00,685 --> 04:15:04,555 APPROPRIATE FOR RESEARCH AND THE 4743 04:15:04,622 --> 04:15:05,857 SUPPORT CORPS WOULD PROVIDE SEED 4744 04:15:05,923 --> 04:15:07,291 FUNDING FOR REGULATORY SUPPORT 4745 04:15:07,358 --> 04:15:09,727 IN RESEARCH APPLICATION 4746 04:15:09,794 --> 04:15:11,829 DEVELOPMENT. 4747 04:15:11,896 --> 04:15:14,532 SO THERE'S A NUMBER OF A LA 4748 04:15:14,599 --> 04:15:15,767 CARTE RESEARCH AREAS FOR US AND 4749 04:15:15,833 --> 04:15:18,736 OUR PARTNER INSTITUTIONS THAT 4750 04:15:18,803 --> 04:15:20,071 RESOURCE APPLICANTS CAN RESPOND 4751 04:15:20,138 --> 04:15:25,043 TO AND SOLICIT APPLICATIONS FOR 4752 04:15:25,109 --> 04:15:27,912 SEED FUNDING PROPOSALS I 4753 04:15:27,979 --> 04:15:30,248 ENCOURAGE TO LOOK AT WITHIN THE 4754 04:15:30,314 --> 04:15:30,715 RFA. 4755 04:15:30,782 --> 04:15:32,250 WE'RE EXCITED AT NCCIH ABOUT THE 4756 04:15:32,316 --> 04:15:33,284 CENTER AND THE POTENTIAL TO 4757 04:15:33,351 --> 04:15:37,455 SERVE AS A FOCAL POINT FOR 4758 04:15:37,522 --> 04:15:41,726 CANNABIS RESEARCH AND HAPPY TO 4759 04:15:41,793 --> 04:15:45,697 ANSWER QUESTIONS AND THREW FOR 4760 04:15:45,763 --> 04:15:50,034 YOUR ATTENTION. 4761 04:15:50,101 --> 04:15:56,507 >> LIKE YOU SAID, IF WANT TO 4762 04:15:56,574 --> 04:15:58,743 HAVE MORE CONVERSATIONS REACH 4763 04:15:58,810 --> 04:16:00,144 OUT. 4764 04:16:00,211 --> 04:16:05,750 NEXT IS DR. ARCHING LA ARENSDORF 4765 04:16:05,817 --> 04:16:09,721 TALKING ABOUT TRANS GROUP WE 4766 04:16:09,787 --> 04:16:16,861 CALL T CREW THIS IS COMPOSED OF 4767 04:16:16,928 --> 04:16:21,699 MANY I.C.s AND ANGELA WILL TELL 4768 04:16:21,766 --> 04:16:32,243 US WHAT THEY'VE BEEN UP TO. 4769 04:17:02,607 --> 04:17:12,950 BEAUTIFUL PRESENTATION. 4770 04:17:53,825 --> 04:17:57,662 >> I'M ALSO GOING TO PUT A PLUG 4771 04:17:57,728 --> 04:18:02,767 IN FOR NASEM REPORT AND I READ 4772 04:18:02,834 --> 04:18:04,235 IT AND IT'S A LOT THERE. 4773 04:18:04,302 --> 04:18:07,171 I'M NOT GOING TO BELABOR THE 4774 04:18:07,238 --> 04:18:08,206 POINT HERE. 4775 04:18:08,272 --> 04:18:16,881 THE TAKE HOME MESSAGE IS THAT WE 4776 04:18:16,948 --> 04:18:17,849 NEED MORE RESEARCH INTO THE 4777 04:18:17,915 --> 04:18:19,417 HEALTH EFFECTS OF THIS BUT I 4778 04:18:19,483 --> 04:18:20,618 RECOMMEND EVERYBODY LOOK AT THIS 4779 04:18:20,685 --> 04:18:21,152 BECAUSE IT'S A GREAT DATA 4780 04:18:21,219 --> 04:18:31,362 SOURCE. 4781 04:18:32,463 --> 04:18:33,865 THIS IS WHERE WE STARTED WITH 4782 04:18:33,931 --> 04:18:39,370 THE REPORT AND SAW THE NEED FOR 4783 04:18:39,437 --> 04:18:47,111 MORE AFFECTS INTO THE POTENTIAL 4784 04:18:47,178 --> 04:18:50,047 AND THERE'S A GRAPH OF NIH 4785 04:18:50,114 --> 04:18:51,883 FUNDING FOR CANNABIS AND 4786 04:18:51,949 --> 04:18:54,452 CANNABINOID RELATED RESEARCH 4787 04:18:54,518 --> 04:18:56,520 FROM 2018 TO 2022. 4788 04:18:56,587 --> 04:18:58,422 AND SADLY I DID NOT GET THE 4789 04:18:58,489 --> 04:19:00,958 UPDATED DATA FOR 2023 BY THE 4790 04:19:01,025 --> 04:19:02,894 TIME WE NEEDED IT. 4791 04:19:02,960 --> 04:19:07,899 IF THE KEY WAS THERE, THE BLUE 4792 04:19:07,965 --> 04:19:08,733 LINE WOULD BE HOW MUCH 4793 04:19:08,799 --> 04:19:11,302 COLLECTIVELY WE HAVE BEEN 4794 04:19:11,369 --> 04:19:12,003 SPENDING ON THERAPEUTIC 4795 04:19:12,069 --> 04:19:17,241 CANNABINOID RESEARCH AND THE RED 4796 04:19:17,308 --> 04:19:18,743 IS ALL OTHER CANNABINOID 4797 04:19:18,809 --> 04:19:21,712 RESEARCH AND YOU CAN SEE THAT 4798 04:19:21,779 --> 04:19:23,748 WE'RE STILL NOT INVESTING AS 4799 04:19:23,814 --> 04:19:29,687 MUCH AS IN THE THERAPY AS IN THE 4800 04:19:29,754 --> 04:19:29,887 OTHER. 4801 04:19:29,954 --> 04:19:30,621 BUT WE'RE GOING UP SO THAT IS 4802 04:19:30,688 --> 04:19:37,762 NICE. 4803 04:19:37,828 --> 04:19:40,464 WE'RE TRYING TO FIGURE OUT HOW 4804 04:19:40,531 --> 04:19:41,432 TO WORK ACROSS THE NIH TO 4805 04:19:41,499 --> 04:19:44,402 CONTINUE THE TRAJECTORY OF 4806 04:19:44,468 --> 04:19:45,703 THERAPEUTIC POTENTIAL RESEARCH 4807 04:19:45,770 --> 04:19:51,075 GOING UP. 4808 04:19:51,142 --> 04:19:54,145 I BELIEVE IN 2022 WE ESTABLISHED 4809 04:19:54,211 --> 04:19:56,914 A TRANS-NIH WORKING GROUP 4810 04:19:56,981 --> 04:20:02,186 BECAUSE WE LOVE OUR GROUPS. 4811 04:20:02,253 --> 04:20:05,189 AND WE HAVE AFFECTIONATELY 4812 04:20:05,256 --> 04:20:08,859 REFERRED TO IT AS T CREW WHICH 4813 04:20:08,926 --> 04:20:10,027 STANDS FOR THERAPEUTIC 4814 04:20:10,094 --> 04:20:11,329 CANNABINOID RESEARCH WORKING 4815 04:20:11,395 --> 04:20:11,862 GROUP. 4816 04:20:11,929 --> 04:20:18,436 THE GOAL FOR THE GROUP WAS THAT 4817 04:20:18,502 --> 04:20:21,772 WE WORK TOGETHER TO FIGURE OUT 4818 04:20:21,839 --> 04:20:22,606 HOW TO EXPAND CANNABINOID 4819 04:20:22,673 --> 04:20:23,474 RESEARCH AND THE RESEARCH 4820 04:20:23,541 --> 04:20:23,774 COMMUNITY. 4821 04:20:23,841 --> 04:20:28,913 WE DO A VARIETY OF ACTIVITIES 4822 04:20:28,980 --> 04:20:29,714 THESE ARE THE BIG FOUR AND 4823 04:20:29,780 --> 04:20:34,685 TRYING TO FIGURE OUT HOW TO 4824 04:20:34,752 --> 04:20:35,686 STRATEGIZE TO WORK WITHIN THE 4825 04:20:35,753 --> 04:20:40,992 DIETARY GUIDELINES AND RESEARCH 4826 04:20:41,058 --> 04:20:45,896 IN THE SPACE AND COLLABORATE AND 4827 04:20:45,963 --> 04:20:49,633 SHARE IMPORTANT INFORMATION AND 4828 04:20:49,700 --> 04:20:51,535 DEVELOP AND STRENGTHEN 4829 04:20:51,602 --> 04:20:52,136 I.C.-SPECIFIC INTEREST IN THE 4830 04:20:52,203 --> 04:20:59,844 SPACE. 4831 04:20:59,910 --> 04:21:01,912 ON THE RIGHT ARE THE NUMBER OF 4832 04:21:01,979 --> 04:21:05,716 NIH INSTITUTES AND CENTERS THAT 4833 04:21:05,783 --> 04:21:08,085 FORM THE RESEARCH. 4834 04:21:08,152 --> 04:21:11,655 AND THE ONES IN RED I WANT TO 4835 04:21:11,722 --> 04:21:13,824 HIGHLIGHT THOSE ARE THE ONES 4836 04:21:13,891 --> 04:21:16,427 THAT ARE T CREW MEMBERS. 4837 04:21:16,494 --> 04:21:17,962 THERE'S INTEREST ACROSS THE NIH. 4838 04:21:18,029 --> 04:21:23,968 IT ISN'T JUST US OR NIDA. 4839 04:21:24,035 --> 04:21:26,470 THERE'S A LOT OF POTENTIAL 4840 04:21:26,537 --> 04:21:27,071 FUNDING THERE. 4841 04:21:27,138 --> 04:21:28,939 SO WHAT HAVE WE ACCOMPLISHED 4842 04:21:29,006 --> 04:21:29,373 THUS FAR? 4843 04:21:29,440 --> 04:21:34,979 WITH HAVE DONE A GOOD JOB OF 4844 04:21:35,046 --> 04:21:36,547 INCREASING COMMUNICATION BETWEEN 4845 04:21:36,614 --> 04:21:38,616 THE I.C.s. 4846 04:21:38,682 --> 04:21:48,359 PATRICK MENTIONED THE RFI THAT 4847 04:21:48,426 --> 04:21:49,560 LED TO THE DEVELOPMENT OF THE 4848 04:21:49,627 --> 04:21:51,095 RESOURCE CENTER AND I'LL TALK 4849 04:21:51,162 --> 04:21:53,130 ABOUT THE GREAT RESOURCE THAT I 4850 04:21:53,197 --> 04:21:54,832 COUNT WHENEVER I CAN THAT ALSO 4851 04:21:54,899 --> 04:21:59,070 CAME OUT OF T CREW WHICH IS A 4852 04:21:59,136 --> 04:21:59,804 WEB PAGE DESIGN SPECIFICALLY FOR 4853 04:21:59,870 --> 04:22:10,081 RESEARCHERS. 4854 04:22:16,287 --> 04:22:22,626 WE TRIED TO MAKE IT A ONE-STOP 4855 04:22:22,693 --> 04:22:29,066 SHOP AND HAVE FOUR AREAS THE 4856 04:22:29,133 --> 04:22:31,001 FIRST IS SHOWING THE RESEARCH 4857 04:22:31,068 --> 04:22:32,636 INTERESTS AND IF YOU HAVE A 4858 04:22:32,703 --> 04:22:34,572 SPECIFIC INTEREST YOU CAN GO AND 4859 04:22:34,638 --> 04:22:45,249 TRY TO SEE WHAT II.C.OPPORTUNIT 4860 04:22:50,454 --> 04:22:51,122 AND THESE ARE SPECIFIC TO 4861 04:22:51,188 --> 04:22:51,655 CANNABIS AND CANNABINOID 4862 04:22:51,722 --> 04:22:56,560 RESEARCH. 4863 04:22:56,627 --> 04:22:59,864 THE NEXT IS A LIST OF THE 4864 04:22:59,930 --> 04:23:02,766 PROGRAM OFFICERS AND CONTACT 4865 04:23:02,833 --> 04:23:06,170 INFORMATION AND LASTLY LINKS TO 4866 04:23:06,237 --> 04:23:11,308 OTHER RESOURCES SUCH AS NIH 4867 04:23:11,375 --> 04:23:14,345 RESOURCES, FDA RESOURCES, DEA 4868 04:23:14,411 --> 04:23:18,315 RESOURCES. 4869 04:23:18,382 --> 04:23:19,350 THERE'S A LOT OF GREAT 4870 04:23:19,416 --> 04:23:23,187 INFORMATION HERE ALSO THERE'S 4871 04:23:23,254 --> 04:23:28,959 LINK TO REPORTER AND ALL THE 4872 04:23:29,026 --> 04:23:30,294 GRANTS THAT HAVE BEEN FUNDED AND 4873 04:23:30,361 --> 04:23:31,662 SEE WHAT HAS BEEN DONE WHEN YOU 4874 04:23:31,729 --> 04:23:33,631 PROPOSE YOUR IDEA. 4875 04:23:33,697 --> 04:23:34,498 THIS IS MY LAST SLIDE. 4876 04:23:34,565 --> 04:23:41,472 I WANT TO PUT IN ANOTHER PLUG. 4877 04:23:41,539 --> 04:23:44,208 RARITY ON THERE WILL BE A 4878 04:23:44,275 --> 04:23:46,143 SESSION ON THE SPECIFIC INTEREST 4879 04:23:46,210 --> 04:23:47,344 WE T CREW MEMBERS. 4880 04:23:47,411 --> 04:23:50,281 WITH THAT I WILL STOP AND NOT 4881 04:23:50,347 --> 04:23:59,456 SURE IF I MADE UP TIME. 4882 04:23:59,523 --> 04:24:04,328 >> NEXT WE HAVE A COLLEAGUE FROM 4883 04:24:04,395 --> 04:24:06,497 OUTSIDE NCCIH AND WE'LL HEAR 4884 04:24:06,564 --> 04:24:12,970 FROM MARY MacDONALD TELL US 4885 04:24:13,037 --> 04:24:15,873 ABOUT THE NIDA DRUG SUPPLY 4886 04:24:15,940 --> 04:24:17,074 PROGRAM AN OTHER RESOURCES THAT 4887 04:24:17,141 --> 04:24:17,942 MAY BE BENEFICIAL FOR YOUR 4888 04:24:18,008 --> 04:24:18,209 RESEARCH. 4889 04:24:18,275 --> 04:24:28,552 THANK YOU, MARY. 4890 04:24:35,559 --> 04:24:38,762 >> GOOD AFTERNOON I'M FROM NIDA 4891 04:24:38,829 --> 04:24:41,699 AND HERE TO UPDATE YOU ON THE 4892 04:24:41,765 --> 04:24:44,468 NIDA DRUG SUPPLY PROGRAM. 4893 04:24:44,535 --> 04:24:47,404 THE PROGRAM HAS BEEN IN 4894 04:24:47,471 --> 04:24:54,878 EXISTENCE SINCE THE EARLY 1980s 4895 04:24:54,945 --> 04:24:56,480 TO PROVIDE PRODUCTS TO 4896 04:24:56,547 --> 04:24:58,816 RESEARCHERS FREE OF CHARGE AND 4897 04:24:58,882 --> 04:25:00,317 OUR INVENTORY IS COMPRISED OF 4898 04:25:00,384 --> 04:25:05,689 ITEMS CONTROLLED BY THE FDA 4899 04:25:05,756 --> 04:25:06,657 EITHER COMMERCIALLY UNAVAILABLE 4900 04:25:06,724 --> 04:25:09,693 OR HARD TO GET OR EXPENSIVE FOR 4901 04:25:09,760 --> 04:25:11,328 RESEARCHERS AND THE PROGRAM IS 4902 04:25:11,395 --> 04:25:12,863 ADMINISTERED THROUGH A SERIES OF 4903 04:25:12,930 --> 04:25:15,332 CONTRACTS AND THE CONTRACTS 4904 04:25:15,399 --> 04:25:17,701 COVER THE PROCUREMENT OR 4905 04:25:17,768 --> 04:25:19,737 SYNTHESIS OF SMALL MOLECULE AND 4906 04:25:19,803 --> 04:25:21,705 PEPTIDES AND THEIR ANALYSIS AND 4907 04:25:21,772 --> 04:25:24,408 STORAGE AND ALSO A CONTRACT WITH 4908 04:25:24,475 --> 04:25:25,242 A MARIJUANA FARM FOR OUR 4909 04:25:25,309 --> 04:25:32,249 CANNABIS PRODUCTS. 4910 04:25:32,316 --> 04:25:33,250 THE PROGRAM COVERS A LOT OF 4911 04:25:33,317 --> 04:25:33,617 ACTIVITIES. 4912 04:25:33,684 --> 04:25:36,453 WE PRIMARILY REVIEW REQUESTS TO 4913 04:25:36,520 --> 04:25:37,621 THE DRUG SUPPLY PROGRAM AND 4914 04:25:37,688 --> 04:25:42,660 COMMUNICATE WITH THE RESEARCHERS 4915 04:25:42,726 --> 04:25:47,898 TO UNDERSTAND THEIR NEEDS OTHER 4916 04:25:47,965 --> 04:25:51,101 ARE REPORTS FROM THE DEA AND 4917 04:25:51,168 --> 04:25:55,572 FORENSICS TO FIND OUT EMERGING 4918 04:25:55,639 --> 04:25:57,441 COMPOUNDS THAT COULD BE OF USE 4919 04:25:57,508 --> 04:26:00,244 TO RESEARCHERS AND WE CAN GET 4920 04:26:00,311 --> 04:26:01,312 FOR THE INVENTORY. 4921 04:26:01,378 --> 04:26:11,922 THE PROGRAM ALSO PROVIDES AN -- 4922 04:26:14,591 --> 04:26:16,727 ANALYTICAL CRYSTALLOGRAPHY AND 4923 04:26:16,794 --> 04:26:18,896 DO A METHOD DEVELOPMENT FOR 4924 04:26:18,962 --> 04:26:22,933 STUDIES AND CAN DO STABILITY 4925 04:26:23,000 --> 04:26:24,868 STUDIES FOR PLANT-BASED 4926 04:26:24,935 --> 04:26:27,237 MATERIALS FOR DRUG SUBSTANCES 4927 04:26:27,304 --> 04:26:28,906 AND PRODUCTS. 4928 04:26:28,972 --> 04:26:31,475 SO OUR INVENTORY COMPRISES 4929 04:26:31,542 --> 04:26:42,086 STIMULANTS, SEDATIVES, AND OTHER 4930 04:26:51,895 --> 04:26:52,963 PRODUCTS AND IF YOU DON'T SEE IT 4931 04:26:53,030 --> 04:26:56,367 YOU CAN CONTACT US WITH THE 4932 04:26:56,433 --> 04:26:57,434 QUESTION AND THE E-MAIL IS 4933 04:26:57,501 --> 04:27:07,644 LISTED. 4934 04:27:07,945 --> 04:27:10,114 AND THE SHOULD GET BACK TO YOU 4935 04:27:10,180 --> 04:27:11,548 QUICKLY TO LET YOU KNOW IF YOUR 4936 04:27:11,615 --> 04:27:12,449 COMPOUND IS IN THE INVENTORY AND 4937 04:27:12,516 --> 04:27:19,957 YOU CAN MOVE ON FROM THERE. 4938 04:27:20,023 --> 04:27:21,225 WE GET OUR CANNABIS THROUGH OR 4939 04:27:21,291 --> 04:27:21,859 CONTRACT WITH THE UNIVERSITY OF 4940 04:27:21,925 --> 04:27:25,529 PLIS MISS. 4941 04:27:25,596 --> 04:27:29,233 -- MISSISSIPPI AND FOR A LONG 4942 04:27:29,299 --> 04:27:30,834 TIME WE WERE THE ONLY PROVIDER 4943 04:27:30,901 --> 04:27:41,445 OF MARIJUANA RESEARCH AND THEY 4944 04:27:43,147 --> 04:27:45,115 RECENTLY APPROVED OTHERS AND 4945 04:27:45,182 --> 04:27:46,283 RESEARCHERS WHO RECEIVEFUL 4946 04:27:46,350 --> 04:27:50,020 FUNDING FOR THEIR WORK CAN ONLY 4947 04:27:50,087 --> 04:27:52,723 PROCURE MATERIALS THROUGH ONE OF 4948 04:27:52,790 --> 04:27:53,857 THESE FEDERALLY APPROVED 4949 04:27:53,924 --> 04:27:59,696 PROVIDERS. 4950 04:27:59,763 --> 04:28:03,200 OUR CANNABIS CONTRACT PROVIDES 4951 04:28:03,267 --> 04:28:05,702 CANNABIS FOR HUMAN USE AND 4952 04:28:05,769 --> 04:28:07,304 EXTRACTS AN CANNABINOIDS AND 4953 04:28:07,371 --> 04:28:09,039 ONCE AGAIN THESE MATERIALS ARE 4954 04:28:09,106 --> 04:28:12,910 ALSO AVAILABLE FREE OF CHARGE TO 4955 04:28:12,976 --> 04:28:15,846 RESEARCHERS WHO SUBMIT COMPLETE 4956 04:28:15,913 --> 04:28:20,317 REQUEST PACKAGES APPROVED. 4957 04:28:20,384 --> 04:28:24,555 AND THE GROUP MAINTAINS THE DRUG 4958 04:28:24,621 --> 04:28:26,190 MASTER FILES AND KEEP A 4959 04:28:26,256 --> 04:28:29,893 COLLECTION OF THE GERMPLASMS FOR 4960 04:28:29,960 --> 04:28:31,495 THE VARIOUS PLANT VARIETIES AND 4961 04:28:31,562 --> 04:28:34,498 ALSO RUN A POTENCY MONITORING 4962 04:28:34,565 --> 04:28:37,701 PROGRAM IN WHICH THEY ANALYZE 4963 04:28:37,768 --> 04:28:40,804 SAMPLES THAT ARE CONFISCATED BY 4964 04:28:40,871 --> 04:28:46,009 LAW ENFORCEMENT. 4965 04:28:46,076 --> 04:28:47,177 THE SPECIFIC PRODUCTS WE GET 4966 04:28:47,244 --> 04:28:51,815 FROM THE UNIVERSITY OF 4967 04:28:51,882 --> 04:28:56,286 MISSISSMISS 4968 04:28:56,353 --> 04:28:59,423 INCLUDE HOMOGENIZED PLANT 4969 04:28:59,490 --> 04:29:04,695 MATERIALS AND GET BULK PLACEBO 4970 04:29:04,761 --> 04:29:08,832 PLANT MATERIAL FOR HUMAN USE. 4971 04:29:08,899 --> 04:29:11,301 THERE'S A NUMBER OF PURIFIED 4972 04:29:11,368 --> 04:29:14,137 CANNABINOIDS INCLUDING DELTA 9, 4973 04:29:14,204 --> 04:29:24,748 THC AND DELTA 8 AND CDC, CBG AND 4974 04:29:25,816 --> 04:29:31,755 THERE'S NCBD RICH EXTRACT FOR 4975 04:29:31,822 --> 04:29:33,323 HUMAN USE AND MAKE CANNABIS 4976 04:29:33,390 --> 04:29:34,091 CIGARETTES AVAILABLE IN PLACEBO 4977 04:29:34,157 --> 04:29:38,762 AND ACTIVE FORMS. 4978 04:29:38,829 --> 04:29:42,099 THEY USE THE STRAIGHT ROLL 4979 04:29:42,165 --> 04:29:44,601 CIGARETTES BUT WE CAN MAKE THEM 4980 04:29:44,668 --> 04:29:49,373 USING THE CONE-SHAPED ROLLERS. 4981 04:29:49,439 --> 04:29:52,776 THE HUMAN USE PRODUCTS ARE 4982 04:29:52,843 --> 04:29:57,915 PRODUCED UNDER GMP CONDITIONS AN 4983 04:29:57,981 --> 04:29:59,583 SHOW THEY MEET THE 4984 04:29:59,650 --> 04:30:01,818 SPECIFICATIONS SET BY THE FDA. 4985 04:30:01,885 --> 04:30:04,121 THE CERTIFICATES OF ANALYSIS 4986 04:30:04,187 --> 04:30:06,223 INCLUDE THE PERCENTAGES OF 4987 04:30:06,290 --> 04:30:11,862 CANNABINOIDS AND PRESENCE OF 4988 04:30:11,929 --> 04:30:22,439 PESTICIDES AND AFLATOXINS AND 4989 04:30:23,140 --> 04:30:25,309 MICROORGANISMS AND BECAUSE IT'S 4990 04:30:25,375 --> 04:30:28,312 DIFFICULT TO GROW PLANT MATERIAL 4991 04:30:28,378 --> 04:30:31,782 UNDER STERILE CONDITIONS THEY 4992 04:30:31,848 --> 04:30:34,484 ADDED AN ERADICATION PROCESS AND 4993 04:30:34,551 --> 04:30:40,324 CHECK IT BEFORE AND AFTER TO 4994 04:30:40,390 --> 04:30:41,925 LOOK AT THE MOISTURE CONTENT 4995 04:30:41,992 --> 04:30:44,194 REMAINS THE SAME AND THEY DO. 4996 04:30:44,261 --> 04:30:45,529 SO IF YOU ARE INTERESTED IN 4997 04:30:45,596 --> 04:30:47,598 SUBMITTING A REQUEST TO THE DRUG 4998 04:30:47,664 --> 04:30:49,499 SUPPLY PROGRAM, YOU CAN CONTACT 4999 04:30:49,566 --> 04:30:53,003 THE MAILBOX AT THE E-MAIL SHOWN 5000 04:30:53,070 --> 04:30:59,610 ABOVE AND THE FOLKS WILL SEND 5001 04:30:59,676 --> 04:31:01,645 YOU A LIST OF REQUIRED DOCUMENTS 5002 04:31:01,712 --> 04:31:04,448 YOU'LL NEED FOR A COMPLETE 5003 04:31:04,514 --> 04:31:07,217 REQUEST PACKAGE AND SOME OF THE 5004 04:31:07,284 --> 04:31:08,685 ITEMS HERE STATE WHAT YOU WANT 5005 04:31:08,752 --> 04:31:10,854 AND HOW MUCH YOU NEED AND THE 5006 04:31:10,921 --> 04:31:13,991 REVIEW PROCESS IS REALLY TO 5007 04:31:14,057 --> 04:31:15,659 JUSTIFY THE AMOUNT THAT YOU'RE 5008 04:31:15,726 --> 04:31:15,959 REQUESTING. 5009 04:31:16,026 --> 04:31:17,894 SO THE PROTOCOL IS TO PUT 5010 04:31:17,961 --> 04:31:19,563 EVERYTHING IN CONTEXT AND WE 5011 04:31:19,630 --> 04:31:25,569 LIKE TO SEE CAL CLAYING -- 5012 04:31:25,636 --> 04:31:27,704 CALCULATIONS AND IF YOU GO TO 5013 04:31:27,771 --> 04:31:29,539 THE SOURCE OF FUNDING YOU DO NOT 5014 04:31:29,606 --> 04:31:30,974 NEED TO HAVE NIH FUNDING TO 5015 04:31:31,041 --> 04:31:32,843 OBTAIN PRODUCTS FROM THE 5016 04:31:32,909 --> 04:31:34,077 PROGRAM. 5017 04:31:34,144 --> 04:31:36,179 IF YOU HAVE EXTERNAL FINDING, 5018 04:31:36,246 --> 04:31:39,616 WE'LL SEND THE REDACTED PACKAGE 5019 04:31:39,683 --> 04:31:42,185 OUT TO TWO EXTERNAL REVIEWERS 5020 04:31:42,252 --> 04:31:44,721 WHO WILL REVIEW IT TO JUSTIFY 5021 04:31:44,788 --> 04:31:47,858 THE AMOUNT OF PRODUCTS YOU'RE 5022 04:31:47,924 --> 04:31:49,693 ASKING FOR AND WE'LL GO ON FROM 5023 04:31:49,760 --> 04:31:51,294 THERE. 5024 04:31:51,361 --> 04:31:53,030 BUT IN OTHER KEY PIECES OF 5025 04:31:53,096 --> 04:31:55,565 INFORMATION ARE A COPY OF YOUR 5026 04:31:55,632 --> 04:32:00,203 DEA LICENSE OR A COPY OF YOUR 5027 04:32:00,270 --> 04:32:04,307 LICENSE FOR RADIO ACTIVITY. 5028 04:32:04,374 --> 04:32:05,809 IF YOU'RE DOING IN VIVO STUDIES 5029 04:32:05,876 --> 04:32:12,683 AN WANT TO AN APPROVED IRB AND 5030 04:32:12,749 --> 04:32:14,418 WE SAY THE REVIEW PROCESS TAKES 5031 04:32:14,484 --> 04:32:16,086 FOUR TO SIX WEEKS BECAUSE THERE 5032 04:32:16,153 --> 04:32:19,990 ARE MULTIPLE LEVELS OF REVIEW. 5033 04:32:20,057 --> 04:32:22,359 SO WITH THAT SAID, THANK YOU FOR 5034 04:32:22,426 --> 04:32:23,560 YOUR ATTENTION AND I'M WILLING 5035 04:32:23,627 --> 04:32:24,194 TO TAKE ANY QUESTIONS 5036 04:32:24,261 --> 04:32:33,336 AFTERWARDS. 5037 04:32:33,403 --> 04:32:35,739 >> THANK YOU SO MUCH. 5038 04:32:35,806 --> 04:32:39,376 THE LAST SPEAKER IS SOMEBODY 5039 04:32:39,443 --> 04:32:41,144 WHO'S LOGO YOU MAY HAVE SEEN IN 5040 04:32:41,211 --> 04:32:46,183 A PRIOR SLIDE, HUNTER LAND WHO 5041 04:32:46,249 --> 04:32:49,686 WORKS WITH THE PHARMACEUTICAL 5042 04:32:49,753 --> 04:32:51,688 RESEARCH AND WILL TALK ABOUT 5043 04:32:51,755 --> 04:32:53,123 COMMERCIAL SUPPLIERS FOR 5044 04:32:53,190 --> 04:32:53,690 CANNABINOIDS. 5045 04:32:53,757 --> 04:32:54,958 >> THANK YOU. 5046 04:32:55,025 --> 04:32:56,793 I'M HUNTER LANCE, VICE PRESIDENT 5047 04:32:56,860 --> 04:32:59,963 OF RESEARCH AND DEVELOPMENT AT 5048 04:33:00,030 --> 04:33:01,598 BRC AND THANK YOU TO THE 5049 04:33:01,665 --> 04:33:05,602 ORGANIZERS FOR INVITING PE IING 5050 04:33:05,669 --> 04:33:06,870 TODAY. 5051 04:33:06,937 --> 04:33:08,171 I DON'T THINK IT WILL TAKE FIVE 5052 04:33:08,238 --> 04:33:10,240 MINUTES BUT I'LL INTRODUCE WHO 5053 04:33:10,307 --> 04:33:10,474 BRC IS. 5054 04:33:10,540 --> 04:33:17,380 WE'RE A SCHEDULE 1 PRODUCER OF 5055 04:33:17,447 --> 04:33:18,982 CANNABIS AND CANNABINOIDS AND 5056 04:33:19,049 --> 04:33:21,051 OUR MISSION IS TO SEE IF 5057 04:33:21,118 --> 04:33:23,954 CANNABINOIDS CAN WORK IN CERTAIN 5058 04:33:24,020 --> 04:33:25,255 DISEASE STATES. 5059 04:33:25,322 --> 04:33:28,692 WE DO PROVIDE AN API OR 5060 04:33:28,759 --> 04:33:29,760 FORMULATIONS FOR RESEARCHERS TO 5061 04:33:29,826 --> 04:33:30,994 WORK WITH US IN COLLABORATION OR 5062 04:33:31,061 --> 04:33:31,928 ON THEIR OWN. 5063 04:33:31,995 --> 04:33:35,732 MANY DIFFERENT PROCESSES TO 5064 04:33:35,799 --> 04:33:36,066 CONSIDER. 5065 04:33:36,133 --> 04:33:39,469 THESE ARE OUR DEA REGISTRATIONS. 5066 04:33:39,536 --> 04:33:42,305 WE HAVE SIX AND CAN IMPORT AND 5067 04:33:42,372 --> 04:33:44,207 EXPORT AND FORMULATE AND 5068 04:33:44,274 --> 04:33:45,575 ETCETERA. 5069 04:33:45,642 --> 04:33:48,411 WE HAVE MANY FORMULATIONS WITH 5070 04:33:48,478 --> 04:33:50,814 ACCELERATED STABILITY UP TO TWO 5071 04:33:50,881 --> 04:33:53,683 YEARS NOW WITH MANY DIFFERENT 5072 04:33:53,750 --> 04:33:57,687 CANNABINOIDS THAT COULD 5073 04:33:57,754 --> 04:33:59,890 POTENTIALLY BE AVAILABLE. 5074 04:33:59,956 --> 04:34:05,362 WE DO MANUFACTURE UNDER GMP AND 5075 04:34:05,429 --> 04:34:09,699 WE DO NOT BREAK FEDERAL LAW 5076 04:34:09,766 --> 04:34:12,736 WHATSOEVER SO YOU'LL NEVER SEE 5077 04:34:12,803 --> 04:34:14,571 PROMOTIONAL MATERIAL FROM US AND 5078 04:34:14,638 --> 04:34:18,608 EVEN OUR NAME DOESN'T HAVE COOL 5079 04:34:18,675 --> 04:34:19,743 NIFTY CANNABINOID CONNECTION. 5080 04:34:19,810 --> 04:34:22,846 IT'S JUST BRC. 5081 04:34:22,913 --> 04:34:25,649 SO I THINK THAT PRETTY MUCH SUMS 5082 04:34:25,715 --> 04:34:26,650 THAT PART UP. 5083 04:34:26,716 --> 04:34:29,686 WE ARE DEDICATED TO COMPLIANCE 5084 04:34:29,753 --> 04:34:31,021 AND QUALITY. 5085 04:34:31,087 --> 04:34:35,392 WE BELIEVE IN GMP. 5086 04:34:35,458 --> 04:34:40,497 WE HAVE SYSTEMS FOR CORRECT 5087 04:34:40,564 --> 04:34:42,599 MANAGEMENT AND WE'VE GOT SEVERAL 5088 04:34:42,666 --> 04:34:47,904 INDs OPEN AND ENROLLING HUMAN 5089 04:34:47,971 --> 04:34:49,539 PATIENTS AND HAVE DONE 5090 04:34:49,606 --> 04:34:50,640 PRE-CLINICAL WORK AS WELL AND 5091 04:34:50,707 --> 04:34:52,409 HAVE A REPUTABLE TEAM. 5092 04:34:52,475 --> 04:34:55,145 OUR CEO IS A FORMER NAVY SEAL 5093 04:34:55,212 --> 04:34:56,980 AND ALSO A STANFORD BUSINESS 5094 04:34:57,047 --> 04:34:57,314 GRAD. 5095 04:34:57,380 --> 04:34:58,982 WE HAVE A WHOLE LIST OF 5096 04:34:59,049 --> 04:35:01,685 RESEARCHERS WITH CANNABINOID 5097 04:35:01,751 --> 04:35:03,053 BACKGROUNDS. 5098 04:35:03,119 --> 04:35:10,894 FORMER DEA, FORMER SCIENTISTS 5099 04:35:10,961 --> 04:35:14,030 AND CHEMISTS THAT KNOW HOW TO 5100 04:35:14,097 --> 04:35:15,966 MANUFACTURE AND FOLLOW 5101 04:35:16,032 --> 04:35:17,234 ESTABLISHED PATHWAYS FOR 5102 04:35:17,300 --> 04:35:17,701 CANNABINOIDS AND DRUG 5103 04:35:17,767 --> 04:35:25,442 DEVELOPMENT. 5104 04:35:25,508 --> 04:35:27,677 WE HAVE INDUSTRY EXPERIENCE AND 5105 04:35:27,744 --> 04:35:28,879 KEY ADVISORS TO MAKE SURE WE 5106 04:35:28,945 --> 04:35:31,047 STAY ON THE STRAIGHT AND NARROW 5107 04:35:31,114 --> 04:35:31,314 PANEL. 5108 04:35:31,381 --> 04:35:34,384 YOU MAY RECOGNIZE SOME OF THESE 5109 04:35:34,451 --> 04:35:36,419 PEOPLE HERE. 5110 04:35:36,486 --> 04:35:37,687 AS WELL AS FORMER COLLEAGUES 5111 04:35:37,754 --> 04:35:44,261 LIKE KATHERINE MAIR WE WORKED 5112 04:35:44,327 --> 04:35:48,298 TOGETHER AT GWU AND MANY MAY 5113 04:35:48,365 --> 04:35:49,933 KNOW BRIAN THOMAS INVOLVED WITH 5114 04:35:50,000 --> 04:35:51,868 US AS WELL. 5115 04:35:51,935 --> 04:35:54,571 THAT CONCLUDES MY VERY SHORT 5116 04:35:54,638 --> 04:35:56,506 INTRODUCTION TO BRC BUT IF 5117 04:35:56,573 --> 04:35:58,008 YOU'RE INTERESTED IN 5118 04:35:58,074 --> 04:35:59,776 COLLABORATING OR API, FEEL FREE 5119 04:35:59,843 --> 04:36:00,110 TO REACH OUT. 5120 04:36:00,176 --> 04:36:06,216 THANKS. 5121 04:36:06,283 --> 04:36:06,983 >> ALL RIGHT. 5122 04:36:07,050 --> 04:36:11,087 WE HAVE A FEW MINUTES FOR 5123 04:36:11,154 --> 04:36:11,354 QUESTIONS. 5124 04:36:11,421 --> 04:36:12,522 WE ARE ACTUALLY QUITE GOOD ON 5125 04:36:12,589 --> 04:36:14,357 TIME AT THE MOMENT. 5126 04:36:14,424 --> 04:36:22,232 SO PLENTY OF TIME FOR QUESTIONS. 5127 04:36:22,299 --> 04:36:23,533 YOU LINE UP EVERYBODY. 5128 04:36:23,600 --> 04:36:29,005 ALICE, FIRST QUESTION OF HUNTER. 5129 04:36:29,072 --> 04:36:39,616 DO YOU GUYS HAVE JUST THE CRUDE 5130 04:36:40,617 --> 04:36:42,619 MATERIAL OR PLANT EXTRACTS? 5131 04:36:42,686 --> 04:36:44,621 >> WE CAN POTENTIALLY SUPPLY 5132 04:36:44,688 --> 04:36:54,864 [OFF-MIC] 5133 04:37:06,576 --> 04:37:09,579 WE DON'T HAVE A STOCK OF EVERY 5134 04:37:09,646 --> 04:37:14,184 MINOR CANNABINOID IN A NEUTRAL 5135 04:37:14,250 --> 04:37:17,787 FORMAT AND EVERY SIMULATION. 5136 04:37:17,854 --> 04:37:22,359 WE HAVE A VARIETY OF THINGS TO 5137 04:37:22,425 --> 04:37:23,760 PRODUCE OR CAN COLLABORATE WITH 5138 04:37:23,827 --> 04:37:24,527 ON RESEARCH. 5139 04:37:24,594 --> 04:37:29,299 >> THANK YOU. 5140 04:37:29,366 --> 04:37:36,206 ANY OTHER QUESTIONS FOR THE NIDA 5141 04:37:36,272 --> 04:37:40,643 FOLKS ON ONGOING RESOURCES AND 5142 04:37:40,710 --> 04:37:41,144 ACTIVITIES. 5143 04:37:41,211 --> 04:37:42,846 IT MUST BE GETTING LATE IN THE 5144 04:37:42,912 --> 04:37:43,013 DAY. 5145 04:37:43,079 --> 04:37:49,586 PEOPLE HAVE FLIGHTS TO CATCH. 5146 04:37:49,652 --> 04:37:52,789 ZIVA WILL CATCH ONE RIGHT NOW. 5147 04:37:52,856 --> 04:37:55,058 >> I'LL ASK A GENERAL QUESTION 5148 04:37:55,125 --> 04:37:58,528 BASED ON THE U24 AND NIDA DRUG 5149 04:37:58,595 --> 04:37:59,062 SUPPLY. 5150 04:37:59,129 --> 04:38:01,531 WHAT IS RESCHEDULING POTENTIALLY 5151 04:38:01,598 --> 04:38:04,634 REDO TO THOSE THINGS. 5152 04:38:04,701 --> 04:38:06,703 THAT TOOK PLACE AFTER. 5153 04:38:06,770 --> 04:38:08,571 >> WE WERE AFRAID YOU'D ASK THAT 5154 04:38:08,638 --> 04:38:09,005 QUESTION. 5155 04:38:09,072 --> 04:38:09,706 I DON'T THINK IT'S BAD 5156 04:38:09,773 --> 04:38:11,241 NECESSARY. 5157 04:38:11,307 --> 04:38:15,045 >> I THINK AS WE WERE THINKING 5158 04:38:15,111 --> 04:38:17,113 ABOUT THIS OBVIOUS ELEPHANT IN 5159 04:38:17,180 --> 04:38:19,849 THE ROOM I THINK WHAT WE CAME 5160 04:38:19,916 --> 04:38:23,453 TO -- WE ALL KNOW IS THE ANSWER. 5161 04:38:23,520 --> 04:38:26,289 AND THEY HAVEN'T ACTUALLY 5162 04:38:26,356 --> 04:38:27,924 CHANGED IT YET. 5163 04:38:27,991 --> 04:38:29,926 NOTHING HAS CHANGE. 5164 04:38:29,993 --> 04:38:33,229 WE'RE STILL IN THE EXACT SAME 5165 04:38:33,296 --> 04:38:34,531 REGULATORY ENVIRONMENT AS WHEN 5166 04:38:34,597 --> 04:38:35,665 THIS WAS ANNOUNCED. 5167 04:38:35,732 --> 04:38:37,700 IT WILL TAKE AT LEAST A YEAR TO 5168 04:38:37,767 --> 04:38:41,271 CHANGE AND THEN THE DETAILS -- 5169 04:38:41,337 --> 04:38:51,848 WHAT EXACTLY IS GOING TO CHANGE? 5170 04:38:51,915 --> 04:38:55,151 I WOULD SUSPECT THERE'S LOTS OF 5171 04:38:55,218 --> 04:38:57,620 INDICATIONS FOR WHAT THIS MEANS 5172 04:38:57,687 --> 04:39:00,323 AND I DON'T HAVE ANSWER UNLESS 5173 04:39:00,390 --> 04:39:10,900 MARY WANTS TO CHIME IN THERE. 5174 04:39:27,083 --> 04:39:34,757 NIDA MEETS SCHEDULE 1 CRITERIA. 5175 04:39:34,824 --> 04:39:39,896 I SUSPECT THOSE WHO HAVE A 5176 04:39:39,963 --> 04:39:41,764 SCHEDULE 1 WILL HAVE MATERIAL 5177 04:39:41,831 --> 04:39:44,033 AND THERE WILL STILL BE TRACKING 5178 04:39:44,100 --> 04:39:46,369 OF PLANT AND API. 5179 04:39:46,436 --> 04:39:48,037 BECAUSE IT'S SCHEDULE 3 DOESN'T 5180 04:39:48,104 --> 04:39:52,742 MEAN YOU CAN JUST GO GET IT. 5181 04:39:52,809 --> 04:39:54,043 THERE'S STILL KETAMINE AND 5182 04:39:54,110 --> 04:39:55,178 THINGS LIKE THAT ON SCHEDULE 1 5183 04:39:55,245 --> 04:39:56,579 YOU CAN'T JUST GET. 5184 04:39:56,646 --> 04:39:57,447 ANYBODY IN THAT SITUATION NOW 5185 04:39:57,514 --> 04:39:59,649 WILL STILL BE ABLE TO APPLY MORE 5186 04:39:59,716 --> 04:40:09,425 QUICKLY. 5187 04:40:09,492 --> 04:40:11,895 >> TO POINT OUT THAT THE NOTICE 5188 04:40:11,961 --> 04:40:17,200 OF PROPOSED RULE MAKING HAS BEEN 5189 04:40:17,267 --> 04:40:18,968 PUBLISHED AND THERE'S A 60 DAY 5190 04:40:19,035 --> 04:40:20,069 OPEN PERIOD FOR COMMENTS. 5191 04:40:20,136 --> 04:40:25,241 IF YOU READ THROUGH THAT, YOU 5192 04:40:25,308 --> 04:40:27,310 WILL NOTICE THERE'S ATTENTION 5193 04:40:27,377 --> 04:40:29,679 MADE TO WHAT THE IMPACT WILL BE 5194 04:40:29,746 --> 04:40:35,118 IN RESEARCH. 5195 04:40:35,185 --> 04:40:41,291 WE'LL SEE ABOUT CHANGES IN VERY 5196 04:40:41,357 --> 04:40:43,826 LITTLE ABOUT RESEARCH AND SO 5197 04:40:43,893 --> 04:40:46,963 ANYBODY COULD COMMENT AND PEOPLE 5198 04:40:47,030 --> 04:40:47,797 IN THE ROOM WILL BE MOST 5199 04:40:47,864 --> 04:40:48,932 EFFECTED AND YOU HAVE AN 5200 04:40:48,998 --> 04:40:51,568 OPPORTUNITY TO WEIGH IN AND SAY 5201 04:40:51,634 --> 04:40:53,703 I HOPE YOU MAKE IT EASIER TO DO 5202 04:40:53,770 --> 04:41:01,411 RESEARCH. 5203 04:41:01,477 --> 04:41:02,312 IT'S POSSIBLE. 5204 04:41:02,378 --> 04:41:05,848 THERE'LL BE A LONG LIST OF RULES 5205 04:41:05,915 --> 04:41:08,451 SIMULATIONS THAT COME OUT IN THE 5206 04:41:08,518 --> 04:41:10,753 PROCESS AND THE DEVIL IS ALWAYS 5207 04:41:10,820 --> 04:41:11,788 IN THE DETAIL AND WHAT IT WILL 5208 04:41:11,854 --> 04:41:13,389 MEAN FOR RESEARCHERS TO GET 5209 04:41:13,456 --> 04:41:15,358 REGISTERED AND WHAT IT WILL MEAN 5210 04:41:15,425 --> 04:41:20,730 FOR ACCESS TO DISPENSARY 5211 04:41:20,797 --> 04:41:22,532 PRODUCTS IS STILL UP IN THE AIR 5212 04:41:22,599 --> 04:41:25,301 AND THE DEA CAN MAKE IT EASIER 5213 04:41:25,368 --> 04:41:28,972 BUT WE'LL NEED TO HEAR FROM 5214 04:41:29,038 --> 04:41:31,474 PEOPLE HOW IT WILL BE AFFECTIVE. 5215 04:41:31,541 --> 04:41:33,910 >> THE QUESTION WHETHER YOU CAN 5216 04:41:33,977 --> 04:41:35,545 NOW USE YOUR LOCAL DISPENSARY 5217 04:41:35,612 --> 04:41:36,713 FOR YOUR FEDERALLY FUNDED 5218 04:41:36,779 --> 04:41:37,213 RESEARCH. 5219 04:41:37,280 --> 04:41:38,681 YOU CAN'T DO IT NOW FOR SURE BUT 5220 04:41:38,748 --> 04:41:40,950 WILL YOU BE ABLE TO WHEN IT'S 5221 04:41:41,017 --> 04:41:41,517 SCHEDULE 3? 5222 04:41:41,584 --> 04:41:42,986 I GUESS THAT DEPENDS ON HOW THEY 5223 04:41:43,052 --> 04:41:49,058 WRITE THE RULE. 5224 04:41:49,125 --> 04:41:49,926 ANYBODY ELSE HAVE QUESTIONS OR 5225 04:41:49,993 --> 04:42:00,069 COMMENTS? 5226 04:42:00,136 --> 04:42:06,509 WE STILL HAVE 15 MINUTES IN THE 5227 04:42:06,576 --> 04:42:06,743 SESSION. 5228 04:42:06,809 --> 04:42:14,117 >> SO THE RESOURCE FUNDED BY 5229 04:42:14,183 --> 04:42:18,588 NCCIH, HOW DOES NCCIH ENVISION 5230 04:42:18,655 --> 04:42:22,325 THE RESEARCH CENTER WILL BE 5231 04:42:22,392 --> 04:42:24,494 SERVED FOR RESEARCHERS? 5232 04:42:24,560 --> 04:42:27,063 FOR EXAMPLE, AT THE MEETINGS IN 5233 04:42:27,130 --> 04:42:28,931 THE FUTURE, WILL THERE BE 5234 04:42:28,998 --> 04:42:30,633 REPRESENTATIVES FROM THE 5235 04:42:30,700 --> 04:42:35,104 RESEARCH CENTER THAT WILL BE 5236 04:42:35,171 --> 04:42:36,506 ABLE TO ANSWER ANSWER QUESTIONS 5237 04:42:36,572 --> 04:42:39,575 OR GUIDE RESEARCHERS ON HOW TO 5238 04:42:39,642 --> 04:42:42,412 SUBMIT INDs OR PROCURE PRODUCT? 5239 04:42:42,478 --> 04:42:44,280 HOW WOULD -- WHAT'S THE VISION 5240 04:42:44,347 --> 04:42:45,381 FOR HOW IT WILL ALL COME 5241 04:42:45,448 --> 04:42:46,983 TOGETHER TO BE ABLE TO PROVIDE 5242 04:42:47,050 --> 04:42:49,085 THIS REALLY IMPORTANT RESOURCE 5243 04:42:49,152 --> 04:42:51,220 AS YOU CAN SEE FROM THE TALKS 5244 04:42:51,287 --> 04:42:51,854 EARLIER TODAY. 5245 04:42:51,921 --> 04:42:53,489 I THINK ACROSS THE BOARD PEOPLE 5246 04:42:53,556 --> 04:42:59,495 ARE HAVING A HARD TIME WITH 5247 04:42:59,562 --> 04:42:59,962 THIS. 5248 04:43:00,029 --> 04:43:05,735 >> THE RESOURCE CENTER UP WAS IN 5249 04:43:05,802 --> 04:43:16,346 DIRECT RESPONSE TO WHERE CAN I 5250 04:43:16,946 --> 04:43:17,980 GO TO THIS PARTICULAR 5251 04:43:18,047 --> 04:43:19,182 CANNABINOID AND WHEN THEY'RE 5252 04:43:19,248 --> 04:43:25,688 STOOD UP AND RUNNING WILL HAVE 5253 04:43:25,755 --> 04:43:31,427 READY ANSWERS AND GUIDE ANCESS 5254 04:43:31,494 --> 04:43:32,528 -- GUIDANCES. 5255 04:43:32,595 --> 04:43:34,497 THEY WON'T BE TESTING YOUR 5256 04:43:34,564 --> 04:43:35,832 PRODUCT OR SUBMITTING ON YOUR 5257 04:43:35,898 --> 04:43:37,700 BEHALF BUT HOPEFULLY BE ABLE TO 5258 04:43:37,767 --> 04:43:41,704 TELL YOU HOW TO NAVIGATE THE 5259 04:43:41,771 --> 04:43:44,107 REGULATORY FRAMEWORK THAT YOU 5260 04:43:44,173 --> 04:43:46,409 HAVE TO NAVIGATE TO DO 5261 04:43:46,476 --> 04:43:53,683 CANNABINOID RESEARCH. 5262 04:43:53,750 --> 04:43:56,686 >> I FEEL LIKE IF WE WERE TO 5263 04:43:56,753 --> 04:43:59,956 TALK TO FDA TO GET GUIDANCE FROM 5264 04:44:00,022 --> 04:44:05,461 THEM -- I'M WONDERING WILL THERE 5265 04:44:05,528 --> 04:44:09,632 BE AN INFRASTRUCTURE THROUGH 5266 04:44:09,699 --> 04:44:12,869 NCCIH TO WORK WITH THE DIFFERENT 5267 04:44:12,935 --> 04:44:13,603 AGENCIES OR JUST A RESOURCE 5268 04:44:13,669 --> 04:44:15,238 CENTER TRYING TO FIGURE IT OUT? 5269 04:44:15,304 --> 04:44:18,875 >> IT'S A COOPERATIVE AGREEMENT. 5270 04:44:18,941 --> 04:44:19,742 THERE'LL BE A LOT OF NCCIH AND 5271 04:44:19,809 --> 04:44:25,681 WITH FUNDING PARTNERS, NCI AND 5272 04:44:25,748 --> 04:44:32,355 NIA AND NIDA AND AS WRITTEN WE 5273 04:44:32,422 --> 04:44:34,724 DID ANTICIPATE THIS GROUP AND 5274 04:44:34,791 --> 04:44:36,726 THERE'LL AB A STEERING COMMIT 5275 04:44:36,793 --> 04:44:42,098 GROUP THERE WILL HAVE OPEN LINES 5276 04:44:42,165 --> 04:44:45,701 OF COMMUNICATION WITH FDA AND 5277 04:44:45,768 --> 04:44:47,170 DEA TO PROVIDE GUIDES. 5278 04:44:47,236 --> 04:44:48,805 WE CAN'T SPEAK FOR DEA OR FDA 5279 04:44:48,871 --> 04:44:50,873 BUT HOPEFULLY WE CAN BE 5280 04:44:50,940 --> 04:44:52,742 COMMUNICATIVE WITH THEM SO WE'RE 5281 04:44:52,809 --> 04:44:57,680 TALKING THE SAME HANG -- 5282 04:44:57,747 --> 04:44:58,915 LANGUAGE AND PROVIDE IF FDA HAS 5283 04:44:58,981 --> 04:45:02,485 A RESOURCE IF YOU TRIED TO 5284 04:45:02,552 --> 04:45:05,354 NAVIGATE THEIR WEBSITE IT'S 5285 04:45:05,421 --> 04:45:07,890 HARDER THAN NIH AND HOPEFULLY 5286 04:45:07,957 --> 04:45:09,559 THE GROUP CAN FIND IT FOR YOU 5287 04:45:09,625 --> 04:45:10,860 AND POINT IT OUT TO YOU AND HAVE 5288 04:45:10,927 --> 04:45:11,994 IT READY IN THE LIBRARY 5289 04:45:12,061 --> 04:45:13,663 SOMEWHERE OF THINGS THEY WOULD 5290 04:45:13,729 --> 04:45:18,968 BE ABLE TO SHARE. 5291 04:45:19,035 --> 04:45:21,070 AND THIS IS MEANT FOR I WANT TO 5292 04:45:21,137 --> 04:45:22,171 GET IN THIS FIELD BUT DON'T KNOW 5293 04:45:22,238 --> 04:45:23,072 HOW TO START. 5294 04:45:23,139 --> 04:45:31,681 YOU GUYS ARE MORE OF THE 5295 04:45:31,747 --> 04:45:33,182 ADVANCED GROUP IN THE FIELD AND 5296 04:45:33,249 --> 04:45:34,584 HAVE ALREADY DONE IT AND YOU 5297 04:45:34,650 --> 04:45:36,719 GUYS HAVE YOUR OWN SET OF 5298 04:45:36,786 --> 04:45:37,186 CHALLENGES. 5299 04:45:37,253 --> 04:45:38,554 BUT THIS IS GEARED TO PEOPLE 5300 04:45:38,621 --> 04:45:40,089 TRYING TO BREAK INTO THE 5301 04:45:40,156 --> 04:45:44,227 CANNABINOID FIELD OR TRYING TO 5302 04:45:44,293 --> 04:45:47,997 EXPAND THE ROSTER OF PEOPLE WHO 5303 04:45:48,064 --> 04:45:49,699 CAN DO CANNABINOID RESEARCH BUT 5304 04:45:49,765 --> 04:45:51,667 THERE'S HIGH BARRIERS TO GET 5305 04:45:51,734 --> 04:45:53,669 PEOPLE INTO THE FIELD AND HOPING 5306 04:45:53,736 --> 04:45:54,504 THE RESOURCE CENTER WILL HELP 5307 04:45:54,570 --> 04:46:05,014 BREAK SOME OF THOSE DOWN. 5308 04:46:06,582 --> 04:46:13,189 >> THANK YOU. 5309 04:46:13,256 --> 04:46:14,657 ALL RIGHT, WELL WE CAN MOVE ON 5310 04:46:14,724 --> 04:46:15,758 TO THE NEXT SESSION. 5311 04:46:15,825 --> 04:46:17,560 THANK YOU TO ALL THE SPEAKERS 5312 04:46:17,627 --> 04:46:18,261 AND TO EVERYONE ELSE. 5313 04:46:18,327 --> 04:46:24,400 WE'LL GO TO THE NEXT ONE. 5314 04:46:24,467 --> 04:46:26,836 THANK YOU, DR. HOPP. 5315 04:46:26,903 --> 04:46:31,607 I WILL THANK OUR GREATER 5316 04:46:31,674 --> 04:46:32,008 SPEAKERS. 5317 04:46:32,074 --> 04:46:37,813 A PARTICULAR THANKS TO NON-NIH 5318 04:46:37,880 --> 04:46:43,085 AND NON-P.I. SPEAKERS. 5319 04:46:43,152 --> 04:46:45,421 SO NOW WE'LL HAVE A BREAK 5320 04:46:45,488 --> 04:46:45,688 ACTUALLY. 5321 04:46:45,755 --> 04:46:48,324 I WANTED TO LET YOU KNOW THAT 5322 04:46:48,391 --> 04:46:50,226 ONE SESSION THAT WILL BE VERY 5323 04:46:50,293 --> 04:46:52,862 IMPORTANT FOR YOU SO WE WILL 5324 04:46:52,929 --> 04:46:57,366 HAVE OUR FDA SPEAKER AND HAVE 5325 04:46:57,433 --> 04:46:59,869 OUR CANNABIS POLICY AND IMPACT 5326 04:46:59,936 --> 04:47:02,004 ON RESEARCH TALKS SO PLEASE BE 5327 04:47:02,071 --> 04:47:03,873 PREPARED WITH YOUR QUESTIONS SO 5328 04:47:03,940 --> 04:47:06,008 WE WILL HAVE THIS SESSION AFTER 5329 04:47:06,075 --> 04:47:07,743 THE BREAK AND THE FINAL SESSION 5330 04:47:07,810 --> 04:47:13,549 WILL BE WITH MY COLLEAGUES FROM 5331 04:47:13,616 --> 04:47:15,051 DIFFERENT INSTITUTES AND NOW 5332 04:47:15,117 --> 04:47:15,418 ENJOY THE BREAK. 5333 04:47:15,484 --> 04:47:19,956 THANK YOU. 5334 04:47:20,022 --> 04:47:21,057 I WILL SEE YOU AT 3:30 IN THE 5335 04:47:21,123 --> 04:47:21,257 ROOM. 5336 04:47:21,324 --> 04:47:49,919 THANK YOU. 5337 04:47:49,986 --> 04:50:19,034 CAPTIONS RETURN SHORTLY 5338 04:50:19,101 --> 04:50:21,003 SCHOOL-BASED STUDY AND FOUND 11% 5339 04:50:21,070 --> 04:50:25,341 OF 12th GRADE STUDENT IN THE 5340 04:50:25,407 --> 04:50:27,376 STUDENTS HAVE USED DELTA 8 IN 5341 04:50:27,443 --> 04:50:29,311 THE PAST YEAR AND WE WERE 5342 04:50:29,378 --> 04:50:30,146 SURPRISED HOW HIGH THE NUMBER 5343 04:50:30,212 --> 04:50:35,618 WAS AND UNDER SCORES HOW 5344 04:50:35,684 --> 04:50:37,319 IMPORTANT IT IS TO DO RESEARCH 5345 04:50:37,386 --> 04:50:38,854 AND HOW PEOPLE ARE USING THE 5346 04:50:38,921 --> 04:50:40,956 SUBSTANCES AS WELL AS THE IMPACT 5347 04:50:41,023 --> 04:50:42,224 ON PUBLIC HEALTH. 5348 04:50:42,291 --> 04:50:46,929 SO BEYOND DELTA 8 WE TALKED 5349 04:50:46,996 --> 04:50:50,399 ABOUT OTHER COMPOUNDS, THC A AND 5350 04:50:50,466 --> 04:50:53,569 DELTA 8 AND OTHERS AND THESE 5351 04:50:53,636 --> 04:50:56,138 PRODUCTS MAY BE HEMP OR NON-HEMP 5352 04:50:56,205 --> 04:50:59,408 DERIVED AND IMPACTS THE CONTROL 5353 04:50:59,475 --> 04:51:00,743 STATUS AS WE'LL TALK ABOUT IN A 5354 04:51:00,810 --> 04:51:01,043 LITTLE BIT. 5355 04:51:01,110 --> 04:51:04,680 I'M NOT CAUSING THAT. 5356 04:51:04,747 --> 04:51:07,149 ANYBODY ONLINE AND JOINED THE 5357 04:51:07,216 --> 04:51:10,386 ZOOM COULD YOU PLEASE MAKE SURE 5358 04:51:10,452 --> 04:51:20,863 YOU MUTE YOURSELF, YOU. 5359 04:51:22,898 --> 04:51:24,900 CANNABIS PRODUCTS CONTAINING 5360 04:51:24,967 --> 04:51:35,511 DELTA 9 ON -- THES THIS IS FOR 5361 04:51:40,015 --> 04:51:45,754 SUBSTANCES WITH HIGH USE AND IN 5362 04:51:45,821 --> 04:51:46,689 2019 CONGRESS PASSED THE ACT TO 5363 04:51:46,755 --> 04:51:52,728 DECONTROL -- CANNABIS LESS THAN 5364 04:51:52,795 --> 04:51:57,132 OR EQUAL TO -- OKAY, WELL THEN 5365 04:51:57,199 --> 04:51:59,401 SO IMPORTANTLY THE A.I. OR FARM 5366 04:51:59,468 --> 04:52:10,012 BILL DID NOT IMPACT THE THCs AND 5367 04:52:13,382 --> 04:52:18,587 IMPACTS REGULATING FOR THE 5368 04:52:18,654 --> 04:52:21,590 COSMETICS ACT AND 38 STATES AND 5369 04:52:21,657 --> 04:52:24,693 THE DISTRICT OF COLUMBIA PASSED 5370 04:52:24,760 --> 04:52:25,327 MEDICAL CANNABIS RAISE AND 5371 04:52:25,394 --> 04:52:26,395 THEY'RE HIGHLY VARIABLE IN TERMS 5372 04:52:26,462 --> 04:52:29,098 OF ALLOWABLE CONDITIONS FOR 5373 04:52:29,164 --> 04:52:31,867 WHICH MEDICAL CANNABIS CAN BE 5374 04:52:31,934 --> 04:52:32,668 USED AND WHETHER IT'S AVAILABLE 5375 04:52:32,735 --> 04:52:40,009 IN DISPENSARIES AND WHETHER 5376 04:52:40,075 --> 04:52:41,443 STATES HAVE REGISTRIES AND 5377 04:52:41,510 --> 04:52:41,944 TESTING AND REGULATORY 5378 04:52:42,011 --> 04:52:52,254 ENVIRONMENTS. 5379 04:53:00,729 --> 04:53:07,036 AND AT THE STATE LEVEL THE 5380 04:53:07,102 --> 04:53:08,270 LEGALITY THERE'S VARIABILITY IN 5381 04:53:08,337 --> 04:53:10,406 HOW STATES TREAT THEM IT'S A 5382 04:53:10,472 --> 04:53:13,642 PATCH WORK. 5383 04:53:13,709 --> 04:53:16,412 WHAT ARE REGULATORY CHALLENGES 5384 04:53:16,478 --> 04:53:17,913 FOR CONDUCTING CANNABIS AND 5385 04:53:17,980 --> 04:53:19,448 CANNABINOID RESEARCH THE BIGGEST 5386 04:53:19,515 --> 04:53:23,319 RELATE TO THE CONTROL STATUS OF 5387 04:53:23,385 --> 04:53:24,019 COURSE. 5388 04:53:24,086 --> 04:53:26,989 MARIJUANA FOR CANNABIS WITH MORE 5389 04:53:27,056 --> 04:53:31,026 THAN 4.3% THC REMAINS A SCHEDULE 5390 04:53:31,093 --> 04:53:32,561 1 DRUG AND THIS CONTRIBUTES TO 5391 04:53:32,628 --> 04:53:33,762 REAL CHALLENGES FOR RESEARCHERS 5392 04:53:33,829 --> 04:53:35,798 IN TERMS OF GETTING THAT 5393 04:53:35,864 --> 04:53:36,932 SCHEDULE 1 REGISTRATION 5394 04:53:36,999 --> 04:53:37,433 ADMINISTRATIVE AND COST 5395 04:53:37,499 --> 04:53:47,710 CHALLENGES. 5396 04:53:51,146 --> 04:53:55,584 AND WE HEARD IT CAN TAKE UP TO A 5397 04:53:55,651 --> 04:53:57,186 YEAR TO GET SCHEDULE 1 5398 04:53:57,252 --> 04:53:58,120 REGISTRATION AND MAY BE REQUIRED 5399 04:53:58,187 --> 04:54:00,055 FOR EACH RESEARCHER IN YOUR LAB 5400 04:54:00,122 --> 04:54:01,156 OR WITHIN DEPARTMENT. 5401 04:54:01,223 --> 04:54:03,692 IF YOU HAVE MULTIPLE LABS YOU 5402 04:54:03,759 --> 04:54:07,429 MAY BE REQUIRED TO REGISTER EACH 5403 04:54:07,496 --> 04:54:08,497 SITE AND THERE'S VARIABILITY IN 5404 04:54:08,564 --> 04:54:09,798 TERMS OF HOW IT'S TREATED. 5405 04:54:09,865 --> 04:54:15,971 WE HEARD IT'S EXPENSIVE TO 5406 04:54:16,038 --> 04:54:25,314 IMPLEMENT THE RIRT -- REQUIRES 5407 04:54:25,381 --> 04:54:32,488 CAMPUS TO MAKE ROOM AND COULD BE 5408 04:54:32,554 --> 04:54:41,930 TIME CONSUMING AND POSE A 5409 04:54:41,997 --> 04:54:46,802 CHALLENGE WITH THOSE WITH LESS 5410 04:54:46,869 --> 04:54:48,704 RESOURCES AND THERE'S 5411 04:54:48,771 --> 04:54:49,038 VARIABILITIES. 5412 04:54:49,104 --> 04:54:56,011 STATES HAVE THEIR OWN CONTROLLED 5413 04:54:56,078 --> 04:54:58,447 SUBSTANCES REGULATIONS AND 5414 04:54:58,514 --> 04:55:01,216 DIFFERENT UNIVERSITIES MAY HAVE 5415 04:55:01,283 --> 04:55:02,618 DIFFERENT REQUIREMENTS AND YOU 5416 04:55:02,684 --> 04:55:03,886 MAY HAVE TO ENROLL OR NOT AND 5417 04:55:03,952 --> 04:55:07,756 ALL THAT SERVES AS A COMPLICATED 5418 04:55:07,823 --> 04:55:08,290 REGULATORY FRAMEWORK FOR 5419 04:55:08,357 --> 04:55:10,426 INVESTIGATORS TO NAVIGATE. 5420 04:55:10,492 --> 04:55:12,027 THERE'S ALSO BEEN CONFUSION OVER 5421 04:55:12,094 --> 04:55:15,030 THE REGULATORY STATUS OF 5422 04:55:15,097 --> 04:55:18,000 CANNABIS PRODUCTS. 5423 04:55:18,067 --> 04:55:20,302 I MENTIONED EARLIER HEMP DERIVED 5424 04:55:20,369 --> 04:55:22,871 CANNABINOIDS WITH LESS THAN THAT 5425 04:55:22,938 --> 04:55:25,140 .3% THC ARE NOT CONTROLLED UNDER 5426 04:55:25,207 --> 04:55:31,013 THE CSA BUT IF THE PRODUCTS ARE 5427 04:55:31,080 --> 04:55:33,749 NON-HEMP DERIVED THEY MAY IN 5428 04:55:33,816 --> 04:55:35,584 CONTROLLED AND YOU HAVE A 5429 04:55:35,651 --> 04:55:36,985 SITUATION WHERE AN IDENTICAL 5430 04:55:37,052 --> 04:55:39,021 CHEMICAL MAY BE CONTROLLED OR 5431 04:55:39,088 --> 04:55:43,058 DE-CONTROLLED DEPENDING ON THE 5432 04:55:43,125 --> 04:55:43,859 PROMINENCE. 5433 04:55:43,926 --> 04:55:44,726 THJ ANOTHER EXAMPLE IN THE NEWS 5434 04:55:44,793 --> 04:55:47,563 A PRECURSOR THAT CONVERTS TO 5435 04:55:47,629 --> 04:55:52,301 DELTA 9 READILY WHEN HEATED AND 5436 04:55:52,367 --> 04:55:54,403 WE -- THE NEWS REPORTS 5437 04:55:54,470 --> 04:55:58,240 INDICATING SENIOR DEA OFFICIALS 5438 04:55:58,307 --> 04:56:02,778 INDICATED THC A LEVEL HAS TO BE 5439 04:56:02,845 --> 04:56:04,113 TAKEN INTO ACCOUNT WHEN 5440 04:56:04,179 --> 04:56:07,983 CONSIDERING THE DELTA 9 LEVEL 5441 04:56:08,050 --> 04:56:14,723 MEETS THE THRESHOLD AND 5442 04:56:14,790 --> 04:56:18,160 CONTROLLING THE THCA AND THIS IS 5443 04:56:18,227 --> 04:56:20,229 SOMETHING A POTENTIAL REGISTRANT 5444 04:56:20,295 --> 04:56:22,464 COMMUNICATED ABOUT THIS AND THIS 5445 04:56:22,531 --> 04:56:23,298 CAME OUT IN THE NEWS. 5446 04:56:23,365 --> 04:56:26,335 IT'S COMPLICATED FOR RESEARCHERS 5447 04:56:26,401 --> 04:56:29,138 TO NAVIGATE AS IS PROBABLY NO 5448 04:56:29,204 --> 04:56:34,176 SURPRISE TO PEOPLE IN THE ROOM. 5449 04:56:34,243 --> 04:56:40,249 AND DISPENSARY PRODUCTS CAN BE 5450 04:56:40,315 --> 04:56:42,217 REGULATED AND UNTIL RECENTLY 5451 04:56:42,284 --> 04:56:43,919 NIDA WAS THE ONLY DOMESTIC 5452 04:56:43,986 --> 04:56:44,853 SOURCE FOR MARIJUANA FOR 5453 04:56:44,920 --> 04:56:47,389 RESOURCE AND HAVE NEWLY 5454 04:56:47,456 --> 04:56:48,223 REGISTERED MANUFACTURERS BUT I 5455 04:56:48,290 --> 04:56:52,461 THINK IT'S A QUESTION OF HOW 5456 04:56:52,528 --> 04:56:54,096 WIDELY THEY'RE PROVIDING 5457 04:56:54,163 --> 04:56:55,230 PRODUCTS TO EXTRAMURAL 5458 04:56:55,297 --> 04:56:55,597 RESEARCHERS. 5459 04:56:55,664 --> 04:56:58,667 AND LATELY THERE'S BEEN IN AN 5460 04:56:58,734 --> 04:57:01,270 CLEAR PATH TO DRUG DEVELOPMENT 5461 04:57:01,336 --> 04:57:04,473 BECAUSE THE NIDA DRUG SUPPLY 5462 04:57:04,540 --> 04:57:06,475 HASN'T BEEN ABLE TO SUPPLY 5463 04:57:06,542 --> 04:57:07,910 SUFFICIENT DEVELOPMENT AND SCALE 5464 04:57:07,976 --> 04:57:10,445 UP AND THE PRODUCT REQUIRED IN 5465 04:57:10,512 --> 04:57:12,814 MONITORING HAS TO BE EQUIVALENT 5466 04:57:12,881 --> 04:57:14,883 TO THE PRODUCT USED FOR THE IND. 5467 04:57:14,950 --> 04:57:16,451 THAT CREATED CHALLENGES FOR 5468 04:57:16,518 --> 04:57:21,790 MEDICAL PRODUCT DEVELOPMENT. 5469 04:57:21,857 --> 04:57:28,463 ALSO NOTE THAT LAST YEAR 5470 04:57:28,530 --> 04:57:30,632 CONGRESS PACKED THE CANNABINOID 5471 04:57:30,699 --> 04:57:31,967 ACT AND EXPANDING RESEARCH ON 5472 04:57:32,034 --> 04:57:33,235 CANNABIS AND CANNABIS PRODUCTS 5473 04:57:33,302 --> 04:57:34,670 INCLUDING BY INCREASING THE 5474 04:57:34,736 --> 04:57:37,906 NUMBER OF AND VARIETY OF 5475 04:57:37,973 --> 04:57:38,941 MANUFACTURERS AUTHORIZED TO 5476 04:57:39,007 --> 04:57:40,309 PROVIDE MARIJUANA FOR RESEARCH 5477 04:57:40,375 --> 04:57:42,678 AND FACILITATING THE PROCESS OF 5478 04:57:42,744 --> 04:57:44,580 OBTAINING A SCHEDULE 1 5479 04:57:44,646 --> 04:57:46,114 REGISTRATION TO CANNABIS 5480 04:57:46,181 --> 04:57:46,415 RESEARCH. 5481 04:57:46,481 --> 04:57:50,452 IT WOULD NOT, DID NOT ADDRESS 5482 04:57:50,519 --> 04:57:53,689 ACCESS TO STATE DISPENSARY 5483 04:57:53,755 --> 04:57:54,089 PRODUCTS. 5484 04:57:54,156 --> 04:57:56,291 THE LAW MUST BEING IMPLEMENTED 5485 04:57:56,358 --> 04:58:00,362 BY THE D.A. AND HAVEN'T SEEN 5486 04:58:00,429 --> 04:58:01,997 REGISTRATION FOR THE PROCESS AND 5487 04:58:02,064 --> 04:58:05,734 REMAINS TO BE SEEN HOW IT WILL 5488 04:58:05,801 --> 04:58:07,302 IMPACT THE SCHEDULE 1 PROCESS 5489 04:58:07,369 --> 04:58:09,104 AND WHETHER IT WILL MAKE IT 5490 04:58:09,171 --> 04:58:10,739 EASIER TO GET THE REGISTRATION. 5491 04:58:10,806 --> 04:58:11,974 WE HAVE FREQUENTLY ASKED 5492 04:58:12,040 --> 04:58:13,442 QUESTIONS ON OUR WEB PAGE AND 5493 04:58:13,508 --> 04:58:15,043 LINKED FROM THE RESOURCES THAT 5494 04:58:15,110 --> 04:58:22,484 ANGELA TOLD YOU ABOUT. 5495 04:58:22,551 --> 04:58:24,620 IT HELPS FROM NAVIGATE AND 5496 04:58:24,686 --> 04:58:27,022 ADDRESSES ISSUES LIKE WHEN IS A 5497 04:58:27,089 --> 04:58:28,390 SCHEDULE 1 REGISTRATION 5498 04:58:28,457 --> 04:58:28,657 REQUIRED. 5499 04:58:28,724 --> 04:58:32,160 THAT IS A VERY SHIFTING 5500 04:58:32,227 --> 04:58:33,462 LANDSCAPE AND YOUR BEST BET 5501 04:58:33,528 --> 04:58:34,496 ABOUT THE CONTROL STATUS OF A 5502 04:58:34,563 --> 04:58:39,034 PRODUCT IS TO CONTACT THE DEA. 5503 04:58:39,101 --> 04:58:42,304 AND WE PROVIDE THE GUIDANCE BUT 5504 04:58:42,371 --> 04:58:44,072 THAT'S THE ULTIMATE BOTTOM LINE 5505 04:58:44,139 --> 04:58:47,743 AND ADDRESSES WHERE RESEARCHERS 5506 04:58:47,809 --> 04:58:50,879 CAN OBTAIN CANNABIS PRODUCTS FOR 5507 04:58:50,946 --> 04:58:54,016 RESEARCH AND THE DRUG SUPPLY AND 5508 04:58:54,082 --> 04:58:55,317 DEA MANUFACTURERS AND WHETHER 5509 04:58:55,384 --> 04:58:56,418 FEDERAL OR NON-FEDERAL FUNDS CAN 5510 04:58:56,485 --> 04:58:59,655 BE USED TO HANDLE THE PRODUCTS 5511 04:58:59,721 --> 04:59:01,590 IF YOU'RE AN NIH RESEARCHER. 5512 04:59:01,657 --> 04:59:03,925 THE SHORT ANSWER IS NO. 5513 04:59:03,992 --> 04:59:06,828 IT DISCUSSES WHAT RESEARCH IS 5514 04:59:06,895 --> 04:59:08,130 PERMISSIBLE WITH PRODUCTS 5515 04:59:08,196 --> 04:59:11,066 OBTAINED BY DISPENSARIES AS WELL 5516 04:59:11,133 --> 04:59:12,534 AS WHETHER AN IND IS NEEDED AND 5517 04:59:12,601 --> 04:59:13,302 FOR THAT WE DIRECT YOU TO THE 5518 04:59:13,368 --> 04:59:17,839 FDA. 5519 04:59:17,906 --> 04:59:21,209 AGAIN, IF YOU HAVE REGULATORY 5520 04:59:21,276 --> 04:59:22,344 QUESTIONS IT'S BEST TO CONTACT 5521 04:59:22,411 --> 04:59:25,447 THE REGULATORY AGENCIES AND WE 5522 04:59:25,514 --> 04:59:26,715 HAVE CONTACT INFORMATION FOR THE 5523 04:59:26,782 --> 04:59:29,985 FDA AND YOU CAN ACCESS THAT VIA 5524 04:59:30,052 --> 04:59:34,156 THE QR CODE OR LINK BELOW AND I 5525 04:59:34,222 --> 04:59:38,026 WANT TO MENTION THAT NIDA AND 5526 04:59:38,093 --> 04:59:39,227 NATIONAL CANCER INSTITUTE ARE 5527 04:59:39,294 --> 04:59:41,563 SPONSORING THIS STUDY FROM THE 5528 04:59:41,630 --> 04:59:43,031 NATIONAL ACADEMIES ON THE PUBLIC 5529 04:59:43,098 --> 04:59:45,934 HEALTH CONSEQUENCES OF CHANGES 5530 04:59:46,001 --> 04:59:49,204 IN THE CANNABIS POLICY LANDSCAPE 5531 04:59:49,271 --> 04:59:52,774 AND THE COMMITTEE IS ADDRESSING 5532 04:59:52,841 --> 04:59:54,176 CANNABIS AND CANNABINOID 5533 04:59:54,242 --> 04:59:56,345 AVAILABILITY AND LOOKING AT 5534 04:59:56,411 --> 04:59:57,512 FRAMEWORK FOR THE CANNABIS 5535 04:59:57,579 --> 05:00:00,615 INDUSTRY AND OUTLINING 5536 05:00:00,682 --> 05:00:02,784 RECOMMENDATIONS TO MINIMIZE 5537 05:00:02,851 --> 05:00:04,086 POTENTIAL HARMS AND INFORM 5538 05:00:04,152 --> 05:00:05,554 POLICY RESEARCH OVER THE NEXT 5539 05:00:05,620 --> 05:00:06,621 FIVE YEARS. 5540 05:00:06,688 --> 05:00:08,690 THAT REPORT SHOULD COME BY THE 5541 05:00:08,757 --> 05:00:10,492 END OF THE YEAR AND WILL BE A 5542 05:00:10,559 --> 05:00:12,627 USEFUL RESOURCE TO ALL OF YOU. 5543 05:00:12,694 --> 05:00:15,030 THAT'S IT AND THANK YOU VERY 5544 05:00:15,097 --> 05:00:19,835 MUCH. 5545 05:00:19,901 --> 05:00:20,369 >> THANK YOU SO MUCH. 5546 05:00:20,435 --> 05:00:25,073 WE'LL MOVE ON TO OUR NEXT 5547 05:00:25,140 --> 05:00:26,408 SPEAKER AND AFTER I'LL INVITE 5548 05:00:26,475 --> 05:00:28,310 YOU TO JOIN ME WHERE YOU GOT 5549 05:00:28,377 --> 05:00:28,844 MICS AVAILABLE TO ANSWER 5550 05:00:28,910 --> 05:00:33,081 QUESTIONS. 5551 05:00:33,148 --> 05:00:37,319 SO, OUR NEXT SPEAKER IS 5552 05:00:37,386 --> 05:00:40,489 DR. REISSIG AT THE CENTER FOR 5553 05:00:40,555 --> 05:00:43,091 DRUG EVALUATION AND RESEARCH AT 5554 05:00:43,158 --> 05:00:44,359 THE U.S. FOOD AND DRUG 5555 05:00:44,426 --> 05:00:44,726 ADMINISTRATION. 5556 05:00:44,793 --> 05:00:50,132 HE HAS BEEN A PHARMACOLOGIST AT 5557 05:00:50,198 --> 05:00:52,467 FDA FOR 15 YEARS AND LEADS THE 5558 05:00:52,534 --> 05:00:53,869 PHARMACOLOGY TEAM IN THE REVIEW 5559 05:00:53,935 --> 05:00:55,470 AND EVALUATION OF DRUGS OF 5560 05:00:55,537 --> 05:00:55,670 ABUSE. 5561 05:00:55,737 --> 05:00:57,038 PRIOR TO JOINING THIS GROUP, HE 5562 05:00:57,105 --> 05:00:59,608 SERVED AS THE BEHAVIORAL AND 5563 05:00:59,674 --> 05:01:01,009 CLINICAL PHARMACOLOGY BRANCH 5564 05:01:01,076 --> 05:01:03,879 CHIEF AT THE CENTER FOR TOBACCO 5565 05:01:03,945 --> 05:01:05,714 PRODUCTS AT FDA AND WILL BE 5566 05:01:05,781 --> 05:01:07,783 PRESENTING CURRENT PRACTICES IN 5567 05:01:07,849 --> 05:01:08,450 REVIEWING THE INVESTIGATIONAL 5568 05:01:08,517 --> 05:01:11,219 NEW DRUG APPLICATIONS INVOLVING 5569 05:01:11,286 --> 05:01:12,921 CANNABIS AND HEMP PRODUCTS. 5570 05:01:12,988 --> 05:01:14,322 I'LL TURN THINGS OVER TO YOU. 5571 05:01:14,389 --> 05:01:15,223 >> WHAT A FLATTERING 5572 05:01:15,290 --> 05:01:24,733 INTRODUCTION. 5573 05:01:24,800 --> 05:01:27,002 I'M A PHARMACOLOGIST WITH FDA AT 5574 05:01:27,068 --> 05:01:27,803 THE CONTROLLED SUBSTANCE STAFF 5575 05:01:27,869 --> 05:01:29,838 AND THE TITLE'S RIGHT THERE. 5576 05:01:29,905 --> 05:01:31,640 I'LL BE TALKING ABOUT OUR 5577 05:01:31,706 --> 05:01:35,010 CURRENT PRACTICES IN REVIEWING 5578 05:01:35,076 --> 05:01:36,778 INDs THAT INVOLVE CANNABIS AND 5579 05:01:36,845 --> 05:01:38,313 HEMP PRODUCTS. 5580 05:01:38,380 --> 05:01:39,748 THIS IS THE STANDARD FDA 5581 05:01:39,815 --> 05:01:41,116 DISCLAIMER. 5582 05:01:41,183 --> 05:01:43,618 THE TALK IS GOING TO BE MY VIEWS 5583 05:01:43,685 --> 05:01:46,488 ALONE AND NOT THOSE OF FDA 5584 05:01:46,555 --> 05:01:50,358 ESPECIALLY IF I MISS SPEAK FOR 5585 05:01:50,425 --> 05:01:51,827 SAY THAT OFFENDS YOU AND I 5586 05:01:51,893 --> 05:01:53,995 CONSIDER MYSELF A BEHAVIORAL 5587 05:01:54,062 --> 05:01:58,366 PHARMACOLOGIST AND THAT'S THE 5588 05:01:58,433 --> 05:02:06,641 LENS I REVIEW UNDER. 5589 05:02:06,708 --> 05:02:10,479 FDA'S A BIG PLACE AND ABOUT 5590 05:02:10,545 --> 05:02:14,783 18,000 PEOPLE WORK THERE AND 5591 05:02:14,850 --> 05:02:17,586 REGULATE A NUMBER OF PRODUCTS 5592 05:02:17,652 --> 05:02:22,824 AND WE REVIEW PRODUCTS AND WE 5593 05:02:22,891 --> 05:02:27,028 LOOK AT BOTH PRESCRIPTION AND 5594 05:02:27,095 --> 05:02:31,032 NON-PRESCRIPTION. 5595 05:02:31,099 --> 05:02:34,002 IF YOU WANT TO RESEARCH AND 5596 05:02:34,069 --> 05:02:36,638 DEVELOP CANNABIS PRODUCTS IT 5597 05:02:36,705 --> 05:02:39,140 STARTS WITH SUBMISSION AS AN IND 5598 05:02:39,207 --> 05:02:42,511 AND MOST PROBABLY KNOW IT 5599 05:02:42,577 --> 05:02:43,111 INCLUDES A LOT OF INFORMATION 5600 05:02:43,178 --> 05:02:44,679 AND INCLUDES THE CHEMISTRY AND 5601 05:02:44,746 --> 05:02:45,747 MANUFACTURING AND QUALITY 5602 05:02:45,814 --> 05:02:56,358 CONTROLS CALL THE CMC DATA AND 5603 05:02:59,995 --> 05:03:01,263 TOXICOLOGY AND YOU CAN REQUEST A 5604 05:03:01,329 --> 05:03:03,098 PREMEETING WITH THE FDA TO GET 5605 05:03:03,164 --> 05:03:04,699 OVERVIEW OF YOUR IND AND WE CAN 5606 05:03:04,766 --> 05:03:07,235 HELP YOU GET IT TOGETHER AND 5607 05:03:07,302 --> 05:03:09,004 SUBMIT IT. 5608 05:03:09,070 --> 05:03:13,842 WE HAVE SEEN A LOT OF GUIDANCES 5609 05:03:13,909 --> 05:03:19,014 TODAY THIS ARE THE MOST RELEVANT 5610 05:03:19,080 --> 05:03:20,282 ONES AND COMPOUNDS AND RECENT 5611 05:03:20,348 --> 05:03:24,219 ONES AND TALK ABOUT SOURCING AND 5612 05:03:24,286 --> 05:03:25,453 THE SAME MANUFACTURING QUALITY 5613 05:03:25,520 --> 05:03:29,624 CONTROLS AND HAD GUIDELINES FOR 5614 05:03:29,691 --> 05:03:31,026 ESTIMATING YOUR THC TO DETERMINE 5615 05:03:31,092 --> 05:03:32,661 WHETHER OR NOT YOU'LL MEET THE 5616 05:03:32,727 --> 05:03:36,464 HEMP DEFINITION AND THE CONTROL. 5617 05:03:36,531 --> 05:03:39,601 OF THE OLDER BOTANICAL DRUG 5618 05:03:39,668 --> 05:03:43,038 GUIDANCE FROM 2016 FOCUSES ON 5619 05:03:43,104 --> 05:03:45,540 QUALITY CONTROLS AND HAS 5620 05:03:45,607 --> 05:03:47,008 INFORMATION ON GROWING 5621 05:03:47,075 --> 05:03:49,344 CONDITIONS FOR YOUR RAW 5622 05:03:49,411 --> 05:03:51,012 BOTANICAL MATERIAL. 5623 05:03:51,079 --> 05:03:52,514 THERE'S THREE BASIC TYPES OF 5624 05:03:52,581 --> 05:03:54,416 INDs. 5625 05:03:54,482 --> 05:03:56,051 THE FIRST IS INVESTIGATOR IND 5626 05:03:56,117 --> 05:03:57,619 FAR AND AWAY THE MOST COMMON ONE 5627 05:03:57,686 --> 05:03:59,020 WE GET. 5628 05:03:59,087 --> 05:04:03,758 THAT IS SUBMITTED BY AN 5629 05:04:03,825 --> 05:04:07,362 INDIVIDUAL THAT WILL INITIATE 5630 05:04:07,429 --> 05:04:09,898 AND CONDUCT RESEARCH AND LOOK AT 5631 05:04:09,965 --> 05:04:14,269 THE INDs ADMINISTERED. 5632 05:04:14,336 --> 05:04:16,504 FOR EXAMPLE, PHYSICIAN OR 5633 05:04:16,571 --> 05:04:18,206 INVESTIGATOR COULD PROPOSE 5634 05:04:18,273 --> 05:04:20,742 STUDYING AN UNAPPROVED DRUG 5635 05:04:20,809 --> 05:04:24,980 BRAND NEW OR APPROVED PRODUCT OR 5636 05:04:25,046 --> 05:04:29,150 NEW INDICATION, A NEW PATIENT 5637 05:04:29,217 --> 05:04:33,588 POPULATION OR DOSE AND AN IND. 5638 05:04:33,655 --> 05:04:36,591 THERE'S EMERGENCY USE INDs THAT 5639 05:04:36,658 --> 05:04:38,693 ALLOWS US TO AUTHORIZE 5640 05:04:38,760 --> 05:04:41,096 EXPERIMENTAL DRUGS IN EMERGENCY 5641 05:04:41,162 --> 05:04:42,964 SITUATIONS AND APPLIES TO 5642 05:04:43,031 --> 05:04:44,432 PATIENTS THAT DON'T MEET 5643 05:04:44,499 --> 05:04:46,935 CRITERIA FOR EXISTING PROTOCOLS 5644 05:04:47,002 --> 05:04:52,507 BUT ARE PRETTY RARE RELATIVELY 5645 05:04:52,574 --> 05:04:55,644 SPEAKING AND THEN THERE'S DRUGS 5646 05:04:55,710 --> 05:04:59,447 THAT SHOW PROMISING TESTING FOR 5647 05:04:59,514 --> 05:05:01,650 SERIOUS AND LIFE-THREATENING 5648 05:05:01,716 --> 05:05:02,117 CONDITIONS. 5649 05:05:02,183 --> 05:05:03,752 INTERNALLY WE BREAK THEM IN 5650 05:05:03,818 --> 05:05:06,354 COMMERCIAL INDs WHERE WE THINK A 5651 05:05:06,421 --> 05:05:08,857 SPONSOR DECLARES THAT THEY WILL 5652 05:05:08,923 --> 05:05:12,694 BE USING THE IND TO SEEK 5653 05:05:12,761 --> 05:05:14,963 MARKETING APPROVAL AND A GENTLE 5654 05:05:15,030 --> 05:05:17,298 REMINDER FOR THOSE THAT DON'T 5655 05:05:17,365 --> 05:05:19,801 KNOW, PHASES 1 THROUGH 3 OF 5656 05:05:19,868 --> 05:05:20,869 CLINICAL TRIALS NEED TO BE 5657 05:05:20,935 --> 05:05:23,004 COMPLETED UNDER IND AND SPONSORS 5658 05:05:23,071 --> 05:05:26,408 HAVE TO SUBMIT AN NDA TO 5659 05:05:26,474 --> 05:05:29,577 FORMALLY PROPOSE US, FDA, TO 5660 05:05:29,644 --> 05:05:30,779 REVIEW THE PROPOSED DRUG TO GET 5661 05:05:30,845 --> 05:05:35,417 A MARKETING APPROVAL. 5662 05:05:35,483 --> 05:05:36,017 THE RESEARCH THAT PROBABLY 5663 05:05:36,084 --> 05:05:40,422 BROUGHT MANY OF YOU HERE IS 5664 05:05:40,488 --> 05:05:40,689 OPPOSITE. 5665 05:05:40,755 --> 05:05:45,727 WHERE THE SPONSOR INDICATES NO 5666 05:05:45,794 --> 05:05:49,130 MARKET APPROVAL AND THE REQUIRED 5667 05:05:49,197 --> 05:05:49,431 INFORMATION. 5668 05:05:49,497 --> 05:05:51,399 WE USE IN CLINICAL TRIALS 5669 05:05:51,466 --> 05:05:53,702 EVERYONE HAS TO MEET FDA 5670 05:05:53,768 --> 05:05:54,703 REQUIREMENTS AND THERE'S THREE 5671 05:05:54,769 --> 05:05:57,639 VERY BROAD AREAS. 5672 05:05:57,706 --> 05:06:00,709 THE FIRST TOXINS. 5673 05:06:00,775 --> 05:06:02,977 THIS HELPS DETERMINE WHETHER IT 5674 05:06:03,044 --> 05:06:04,179 IS REASONABLY SAFE FOR INITIAL 5675 05:06:04,245 --> 05:06:06,081 TESTING IN HUMANS. 5676 05:06:06,147 --> 05:06:08,249 THAT OFTEN INCLUDES ANY PREVIOUS 5677 05:06:08,316 --> 05:06:11,019 HUMAN EXPERIENCE, PRE-CLINICAL 5678 05:06:11,086 --> 05:06:14,656 STUDIES, IN VITRO STUDIES, 5679 05:06:14,723 --> 05:06:14,923 ETCETERA. 5680 05:06:14,989 --> 05:06:16,424 THEN THE BIG ONE, THE 5681 05:06:16,491 --> 05:06:18,593 MANUFACTURING INFORMATION, THE 5682 05:06:18,660 --> 05:06:20,462 CMC AND CHEMISTRY MANUFACTURING 5683 05:06:20,528 --> 05:06:21,329 AND CONTROLS. 5684 05:06:21,396 --> 05:06:23,898 THIS SECTION HAS INFORMATION 5685 05:06:23,965 --> 05:06:27,368 PERTAINING TO COMPOSITION, THE 5686 05:06:27,435 --> 05:06:30,405 MANUFACTURER, THE STABILITY AND 5687 05:06:30,472 --> 05:06:31,906 CONTROL FOR MANUFACTURING THE 5688 05:06:31,973 --> 05:06:34,175 DRUG SUBSTANCE IN THE DRUG AND 5689 05:06:34,242 --> 05:06:35,110 THE DRUG PRODUCT. 5690 05:06:35,176 --> 05:06:37,645 WE HEARD ABOUT THAT IN THE LAST 5691 05:06:37,712 --> 05:06:40,148 TALK ABOUT THE NIDA DRUG SUPPLY. 5692 05:06:40,215 --> 05:06:41,549 FDA USES THE INFORMATION TO 5693 05:06:41,616 --> 05:06:43,551 ENSURE THE COMPANY OR 5694 05:06:43,618 --> 05:06:46,488 INVESTIGATOR CAN ADEQUATELY 5695 05:06:46,554 --> 05:06:47,722 PRODUCE CONSISTENT REPRODUCIBLE 5696 05:06:47,789 --> 05:06:49,224 BATCHES OF THE DRUG. 5697 05:06:49,290 --> 05:06:51,526 SO SPONSORS MUST SUBMIT THIS 5698 05:06:51,593 --> 05:06:54,129 INFORMATION FOR OUR REVIEWERS TO 5699 05:06:54,195 --> 05:06:57,232 ENSURE IDENTIFY, QUALITY, 5700 05:06:57,298 --> 05:06:59,100 PURITY, POTENCY, EVERYTHING 5701 05:06:59,167 --> 05:07:02,203 ABOUT THE PRODUCT TO BE 5702 05:07:02,270 --> 05:07:02,537 ADMINISTERED. 5703 05:07:02,604 --> 05:07:04,339 AND IMPROVED QUANTITATIVE DATA 5704 05:07:04,405 --> 05:07:10,245 AND PHYTE SCRO -- PHYTO 5705 05:07:10,311 --> 05:07:12,680 CHEMICALS AND GUIDELINES TO HELP 5706 05:07:12,747 --> 05:07:15,784 ASSIST SPONSORS IN THEIR 5707 05:07:15,850 --> 05:07:17,786 ANALYTICAL METHODOLOGY FOR 5708 05:07:17,852 --> 05:07:19,387 PROVIDING THIS INFORMATION. 5709 05:07:19,454 --> 05:07:21,923 ANOTHER WAY TO MEET THE CMC 5710 05:07:21,990 --> 05:07:23,591 REQUIREMENTS IS THROUGH 5711 05:07:23,658 --> 05:07:23,925 AUTHORIZATION. 5712 05:07:23,992 --> 05:07:28,463 THAT ALLOWS THE REFERENCE TO A 5713 05:07:28,530 --> 05:07:30,632 DIFFERENT SPONSOR CMC THAT HAS 5714 05:07:30,698 --> 05:07:32,033 ALREADY BEEN ALLOWED BY FDA. 5715 05:07:32,100 --> 05:07:33,835 WE SEE THIS WITH A NUMBER OF 5716 05:07:33,902 --> 05:07:37,338 DRUGS WHERE IF AN INDs ALLOWED 5717 05:07:37,405 --> 05:07:40,341 TO PROCEED, ANOTHER ENTITY CAN 5718 05:07:40,408 --> 05:07:41,876 REFERENCE THE SAME IND. 5719 05:07:41,943 --> 05:07:44,546 AND YOU CAN ALSO SUBMIT A LETTER 5720 05:07:44,612 --> 05:07:49,617 OF AUTHORIZATION ALLOWING FOR 5721 05:07:49,684 --> 05:07:52,253 THE DRUG MASTER FILE HELD BY A 5722 05:07:52,320 --> 05:07:54,222 DIFFERENT ENTITY. 5723 05:07:54,289 --> 05:07:57,025 THE DMFs ARE SUBMITTED TO FDA 5724 05:07:57,091 --> 05:08:00,094 AND PROVIDE CONFIDENTIAL AND 5725 05:08:00,161 --> 05:08:02,831 DETAILED INFORMATION ABOUT THE 5726 05:08:02,897 --> 05:08:04,232 SUBSTANCE, INTERMEDIATES, 5727 05:08:04,299 --> 05:08:05,466 GROWING CONDITIONS,ING YOU CAN 5728 05:08:05,533 --> 05:08:08,970 INCLUDE THINGS LIKE PACKAGING 5729 05:08:09,037 --> 05:08:10,839 MATERIAL, EXCIPIENT COLUMN AND 5730 05:08:10,905 --> 05:08:13,341 OTHER REFERENCE INFORMATION. 5731 05:08:13,408 --> 05:08:15,677 AND FINALLY THE CLINICAL 5732 05:08:15,743 --> 05:08:15,944 PROTOCOL. 5733 05:08:16,010 --> 05:08:18,980 THE CLINICAL PROTOCOL NEEDS TO 5734 05:08:19,047 --> 05:08:19,981 BE DETAILED. 5735 05:08:20,048 --> 05:08:22,617 WE ASK FOR DETAILED PROTOCOLS 5736 05:08:22,684 --> 05:08:24,686 AND ALLOWS US TO DETERMINE THE 5737 05:08:24,752 --> 05:08:26,754 RISK SUBJECTS MAY BE FACING. 5738 05:08:26,821 --> 05:08:29,657 WE ALSO ASK FOR QUALIFICATIONS 5739 05:08:29,724 --> 05:08:32,927 OF CLINICAL INVESTIGATORS. 5740 05:08:32,994 --> 05:08:34,662 WE WANT TO GENERATE THE 5741 05:08:34,729 --> 05:08:37,665 EXPERIENCE OF THE INVESTIGATOR 5742 05:08:37,732 --> 05:08:40,501 AND THEY ARE AT AN ACCREDITED 5743 05:08:40,568 --> 05:08:41,169 INSTITUTION. 5744 05:08:41,236 --> 05:08:43,838 WE ALSO ASK FOR INFORMED CONSENT 5745 05:08:43,905 --> 05:08:47,175 AND COMMITMENT THAT SPONSORS 5746 05:08:47,242 --> 05:08:49,110 HAVE THEIR CLINICAL STUDIES 5747 05:08:49,177 --> 05:08:51,813 REVIEWED BY AN IRB AND THEY'RE 5748 05:08:51,880 --> 05:08:55,016 GOING TO ADHERE TO IND 5749 05:08:55,083 --> 05:08:55,316 REGULATIONS. 5750 05:08:55,383 --> 05:08:58,353 SO, IMPORTANT BULLET, FOLLOWING 5751 05:08:58,419 --> 05:09:00,288 REVIEW OF THE IND, FDA GETS 30 5752 05:09:00,355 --> 05:09:02,223 DAYS TO DETERMINE IF A STUDY CAN 5753 05:09:02,290 --> 05:09:04,058 PROCEED OR GETS PLACED ON HOLD 5754 05:09:04,125 --> 05:09:06,527 AND WE'LL FOLLOW UP WITH A 5755 05:09:06,594 --> 05:09:07,996 DETAILED LETTER EXPLAINING THAT 5756 05:09:08,062 --> 05:09:09,130 HOLD. 5757 05:09:09,197 --> 05:09:12,367 IF AUTHORIZED TO PROCEED FOR 5758 05:09:12,433 --> 05:09:13,635 STUDIES USING SCHEDULE 1 5759 05:09:13,701 --> 05:09:15,503 CANNABIS MATERIAL THEN SPONSORS 5760 05:09:15,570 --> 05:09:16,571 CAN PROCEED WITH DEA PROTOCOL 5761 05:09:16,638 --> 05:09:18,473 REGISTRATION. 5762 05:09:18,539 --> 05:09:21,976 AND UNFORTUNATELY DEA IS NOT 5763 05:09:22,043 --> 05:09:22,577 HERE TO TALK ABOUT THAT VERY 5764 05:09:22,644 --> 05:09:26,814 IMPORTANT COMPONENT. 5765 05:09:26,881 --> 05:09:27,048 SOURCES. 5766 05:09:27,115 --> 05:09:30,618 WE HEARD ABOUT SOURCES OF 5767 05:09:30,685 --> 05:09:31,019 CANNABIS. 5768 05:09:31,085 --> 05:09:33,321 AND I THINK THE TAKE HOME HERE 5769 05:09:33,388 --> 05:09:35,056 IS THAT THEY'RE HELD TO THE SAME 5770 05:09:35,123 --> 05:09:37,759 REGULATORY STANDARDS AS ANY 5771 05:09:37,825 --> 05:09:40,662 OTHER BOTANICAL RAW MATERIAL AND 5772 05:09:40,728 --> 05:09:43,665 DRUG SUBSTANCE OR ANY OTHER 5773 05:09:43,731 --> 05:09:44,599 BOTANICAL DRUG PRODUCT. 5774 05:09:44,666 --> 05:09:48,202 SO SPONSORS MUST MEET ALL THE 5775 05:09:48,269 --> 05:09:49,704 FDA REQUIREMENTS REGARDLESS OF 5776 05:09:49,771 --> 05:09:53,074 THE SOURCE AND SO WE'VE HEARD 5777 05:09:53,141 --> 05:09:55,543 EARLIER TRADITIONAL SOURCES, 5778 05:09:55,610 --> 05:09:58,513 NIDA, THE NIDA DRUG SUPPLY 5779 05:09:58,579 --> 05:09:58,980 PROGRAM. 5780 05:09:59,047 --> 05:10:00,882 HISTORICALLY IT'S BEEN THE ONLY 5781 05:10:00,949 --> 05:10:02,050 DOMESTIC LEGAL SOURCE FOR 5782 05:10:02,116 --> 05:10:03,184 CANNABIS FOR CLINICAL RESEARCH 5783 05:10:03,251 --> 05:10:04,152 AND IT'S PROVIDED BY THE 5784 05:10:04,218 --> 05:10:05,853 UNIVERSITY OF MISSISSIPPI. 5785 05:10:05,920 --> 05:10:07,322 I WON'T GET INTO THAT SINCE WE 5786 05:10:07,388 --> 05:10:10,825 JUST HEARD ABOUT THAT BUT WE 5787 05:10:10,892 --> 05:10:14,162 HERE FROM NEW DEA REGISTRANTS 5788 05:10:14,228 --> 05:10:16,064 AND NOW PRODUCING CANNABIS 5789 05:10:16,130 --> 05:10:17,565 RELATED COMPOUNDS THAT CAN BE 5790 05:10:17,632 --> 05:10:19,033 USED FOR AUTHORIZED 5791 05:10:19,100 --> 05:10:21,736 MANUFACTURING AND RESEARCH. 5792 05:10:21,803 --> 05:10:23,171 SO THERE'S A LINK THERE TO SOME 5793 05:10:23,237 --> 05:10:28,710 OF THE DEA INFORMATION. 5794 05:10:28,776 --> 05:10:31,045 SO MORE GENERAL DRUG BOTANICAL 5795 05:10:31,112 --> 05:10:34,983 DRUG DEVELOPMENT GUIDANCE, WE 5796 05:10:35,049 --> 05:10:39,020 ISSUED OURS IN 2016 TAKING INTO 5797 05:10:39,087 --> 05:10:40,521 ACCOUNT WHAT IS NECESSARY AND 5798 05:10:40,588 --> 05:10:43,024 GIVES CURRENT THINKING LIKE ANY 5799 05:10:43,091 --> 05:10:46,527 OTHER GUIDANCE AND THAT IS 5800 05:10:46,594 --> 05:10:49,664 EXTENDED TO 2024 FROM 2016 AND 5801 05:10:49,731 --> 05:10:52,100 HAS ALL THE INFORMATION YOU SEE 5802 05:10:52,166 --> 05:10:53,868 THERE INCLUDING AGAIN YOU'LL SEE 5803 05:10:53,935 --> 05:10:55,103 THE CHEMISTRY MANUFACTURING AND 5804 05:10:55,169 --> 05:10:57,905 CONTROLS AND IF YOU'RE REALLY 5805 05:10:57,972 --> 05:11:00,174 INTERESTED YOU CAN GOOGLE ALL 5806 05:11:00,241 --> 05:11:02,643 THE FEDERAL REGULATIONS AND READ 5807 05:11:02,710 --> 05:11:05,213 THEM TO YOUR HEART'S CONTENT. 5808 05:11:05,279 --> 05:11:06,748 BUT THIS IS OUR MAIN REGULATORY 5809 05:11:06,814 --> 05:11:11,986 STANDARD AND THE MAIN ONE IS 5810 05:11:12,053 --> 05:11:12,153 DMP. 5811 05:11:12,220 --> 05:11:13,321 SO CURRENT MANUFACTURING 5812 05:11:13,388 --> 05:11:15,390 PRACTICE FOR HUMAN 5813 05:11:15,456 --> 05:11:15,757 PHARMACEUTICALS. 5814 05:11:15,823 --> 05:11:16,758 SO THAT'S OUR RECOMMENDATION FOR 5815 05:11:16,824 --> 05:11:20,028 EVERYONE WHO WANTS TO OR IS 5816 05:11:20,094 --> 05:11:22,130 INTERESTED IN DEVELOPING 5817 05:11:22,196 --> 05:11:26,034 BOTANICAL COMPOUNDS. 5818 05:11:26,100 --> 05:11:27,535 HERES SOME WONDERFUL IMAGES OF 5819 05:11:27,602 --> 05:11:31,472 THE GUIDANCE AND MORE SPECIFIC 5820 05:11:31,539 --> 05:11:32,140 RECOMMENDATIONS OF PHASED 5821 05:11:32,206 --> 05:11:33,474 DEVELOPMENT AND THE LATER YOU 5822 05:11:33,541 --> 05:11:35,009 GET IN DEVELOPMENT, THE MORE 5823 05:11:35,076 --> 05:11:37,378 INFORMATION YOU'RE GOING TO NEED 5824 05:11:37,445 --> 05:11:40,314 AND THAT'S IN ANTICIPATION IF A 5825 05:11:40,381 --> 05:11:41,783 DRUG OR COMPOUND IS APPROACHED 5826 05:11:41,849 --> 05:11:45,119 IT WILL BE DISPENSED TO A WIDER 5827 05:11:45,186 --> 05:11:47,688 AND LARGER SET OF INDIVIDUALS. 5828 05:11:47,755 --> 05:11:49,323 SO WE WANT A LITTLE BIT MORE 5829 05:11:49,390 --> 05:11:50,124 SPECIFIC INFORMATION. 5830 05:11:50,191 --> 05:11:56,597 THE NEW GUIDANCE ALSO REPUBLICS 5831 05:11:56,664 --> 05:11:58,466 A TOTALITY OF EVIDENCE 5832 05:11:58,533 --> 05:11:59,967 APPROACH -- RECOMMENDS A 5833 05:12:00,034 --> 05:12:01,202 TOTALITY OF EVIDENCE APPROACH 5834 05:12:01,269 --> 05:12:03,004 BEFORE A BOTANICAL DRUG PRODUCT 5835 05:12:03,071 --> 05:12:06,874 IS APPROVED. 5836 05:12:06,941 --> 05:12:11,012 WE HEARD ABOUT THE CANNABIS 5837 05:12:11,079 --> 05:12:13,081 DEVELOPMENT FINAL GUIDANCE AND 5838 05:12:13,147 --> 05:12:14,515 MORE RECENT, 2023. 5839 05:12:14,582 --> 05:12:19,520 THAT OUTLINES A LOT OF THE WAYS 5840 05:12:19,587 --> 05:12:21,289 WHICH CANNABIS RESEARCH CAN BE 5841 05:12:21,355 --> 05:12:23,891 DONE UNDER IND AND STATEMENTS ON 5842 05:12:23,958 --> 05:12:25,526 SOURCES, RESOURCES FOR 5843 05:12:25,593 --> 05:12:27,895 INFORMATION ON QUALITY 5844 05:12:27,962 --> 05:12:29,330 CONSIDERATIONS AND OTHER 5845 05:12:29,397 --> 05:12:33,601 CONSIDERATIONS UNDER THE CSA. 5846 05:12:33,668 --> 05:12:39,807 HERE'S THE SUMMARY, WE NEED YOU 5847 05:12:39,874 --> 05:12:41,375 NEED TO OBTAIN THE EXCEPTION TO 5848 05:12:41,442 --> 05:12:43,644 BE APPROVED OF A MARKETING 5849 05:12:43,711 --> 05:12:45,847 APPLICATION BEFORE TRANSPORTED 5850 05:12:45,913 --> 05:12:46,481 OR DISTRIBUTED. 5851 05:12:46,547 --> 05:12:48,316 WHAT THAT MEANS AND WE TALK 5852 05:12:48,382 --> 05:12:49,684 ABOUT INTERSTATE COMMERCE AND 5853 05:12:49,750 --> 05:12:51,018 ONLY APPROVED DRUGS WHEN YOU 5854 05:12:51,085 --> 05:12:53,221 LOOK AT THE FOOD DRUG AND 5855 05:12:53,287 --> 05:12:56,657 COSMETIC ACT CAN BE INTRODUCED 5856 05:12:56,724 --> 05:12:58,359 TO INTERSTATE COMMERCE AND THE 5857 05:12:58,426 --> 05:13:00,061 IND ALLOWS THE EXCEPTION TO 5858 05:13:00,128 --> 05:13:01,229 SHIFT AND TRANSPORT THE DRUG. 5859 05:13:01,295 --> 05:13:02,997 THERE'S THREE TYPES, THE 5860 05:13:03,064 --> 05:13:06,634 INVESTIGATOR, THE BULK OF THEM 5861 05:13:06,701 --> 05:13:08,469 BUT THERE ARE EMERGENCY USE 5862 05:13:08,536 --> 05:13:10,104 TREATMENT INDs. 5863 05:13:10,171 --> 05:13:13,274 THE TWO BASIC CATEGORIES, 5864 05:13:13,341 --> 05:13:14,308 COMMERCIAL AND RESEARCH. 5865 05:13:14,375 --> 05:13:16,344 AND THE REQUIRED INFORMATION IS 5866 05:13:16,410 --> 05:13:17,612 LISTED THERE. 5867 05:13:17,678 --> 05:13:19,547 IT'S PRIMARILY ANIMAL 5868 05:13:19,614 --> 05:13:22,283 PHARMACOLOGY AND TOXICOLOGY 5869 05:13:22,350 --> 05:13:24,752 STUDIES AND CNC INFORMATION AND 5870 05:13:24,819 --> 05:13:25,786 ANYTHING CRITICAL. 5871 05:13:25,853 --> 05:13:26,921 THERE ARE LINKS RIGHT THERE IF 5872 05:13:26,988 --> 05:13:32,860 YOU SUBMIT YOUR INDs AND YOU 5873 05:13:32,927 --> 05:13:42,870 HAVE TO WAIT 30 DAYS OR HERE 5874 05:13:42,937 --> 05:13:44,105 EARLIER AND AT THE END OF THE 5875 05:13:44,172 --> 05:13:45,573 SLIDES AFTER THE ADDITIONAL 5876 05:13:45,640 --> 05:13:47,475 RESOURCES THERE'S A WHOLE BUNCH 5877 05:13:47,542 --> 05:13:50,511 OF LINKS FOR ANY QUESTIONS AND I 5878 05:13:50,578 --> 05:13:52,079 ENCOURAGE YOU TO VISIT ALL THOSE 5879 05:13:52,146 --> 05:13:55,049 LINKS TO HELP FACILITATE YOUR 5880 05:13:55,116 --> 05:14:05,626 WONDERFUL EXPERIENCE WITH FDA. 5881 05:14:06,093 --> 05:14:08,229 >> I'M GOING TO ASK OUR SPEAKERS 5882 05:14:08,296 --> 05:14:09,730 TO COME UP HERE AND FOR PEOPLE 5883 05:14:09,797 --> 05:14:11,165 TO GET READY FOR QUESTIONS. 5884 05:14:11,232 --> 05:14:13,034 UNFORTUNATELY OUR FINAL SPEAKER 5885 05:14:13,100 --> 05:14:15,836 FOR THIS SESSION FROM THE DRUG 5886 05:14:15,903 --> 05:14:16,771 ENFORCEMENT ADMINISTRATION WAS 5887 05:14:16,837 --> 05:14:20,474 UNABLE TO JOIN US AT THE LAST 5888 05:14:20,541 --> 05:14:23,811 MOMENT AND SO DR. HEUETT THE 5889 05:14:23,878 --> 05:14:26,214 CHIEF OF SCHEDULE 1 RESEARCH AND 5890 05:14:26,280 --> 05:14:27,181 INTERNATIONAL CONTROL UNIT AT 5891 05:14:27,248 --> 05:14:32,186 THE DRUG AND CHEMICAL EVALUATION 5892 05:14:32,253 --> 05:14:34,088 SECTION WAS NOT ABLE TO JOIN US 5893 05:14:34,155 --> 05:14:36,457 BUT LET US KNOW THEIR GOAL IS TO 5894 05:14:36,524 --> 05:14:38,559 SUPPORT RESEARCHERS AS THEY 5895 05:14:38,626 --> 05:14:40,461 NAVIGATE THE REGISTRATION 5896 05:14:40,528 --> 05:14:41,929 PROCESS AND PROVIDE THE SUPPORT 5897 05:14:41,996 --> 05:14:43,798 AND HE PROVIDED AN E-MAIL LINK 5898 05:14:43,864 --> 05:14:46,667 THAT WE'LL TRY TO PUT IN THE 5899 05:14:46,734 --> 05:14:48,569 MEETING MINUTES OF A CONTACT FOR 5900 05:14:48,636 --> 05:14:50,037 ANYONE WHO IS INTERESTED IN 5901 05:14:50,104 --> 05:14:51,005 CONDUCTING RESEARCH WITH 5902 05:14:51,072 --> 05:14:55,943 SCHEDULE 1 CONTROLLED SUBSTANCES 5903 05:14:56,010 --> 05:14:59,981 AND TO REACH OUT AND HAPPY TO 5904 05:15:00,047 --> 05:15:02,016 ANSWER QUESTIONS AND HELP 5905 05:15:02,083 --> 05:15:02,416 PEOPLE. 5906 05:15:02,483 --> 05:15:03,684 I'LL START US OFF WITH QUESTIONS 5907 05:15:03,751 --> 05:15:05,586 AS PEOPLE START COMING UP TO ASK 5908 05:15:05,653 --> 05:15:06,587 THEIR QUESTIONS WE'VE GOT 5909 05:15:06,654 --> 05:15:17,031 MICROPHONES AVAILABLE. 5910 05:15:46,694 --> 05:15:48,929 JENNIFER FOR WHY YOUTH ARE USING 5911 05:15:48,996 --> 05:15:50,298 AND WHERE THE INFORMATION IS AND 5912 05:15:50,364 --> 05:15:51,966 IN TERMS OF HOW QUICKLY THE 5913 05:15:52,033 --> 05:15:54,235 PUBLIC IS SHIFTING IN WHAT 5914 05:15:54,302 --> 05:15:58,072 THEY'RE DOING RELATED TO 5915 05:15:58,139 --> 05:16:00,474 CANNABIS AND CANNABIS-RELATED 5916 05:16:00,541 --> 05:16:01,542 COMPOUNDS. 5917 05:16:01,609 --> 05:16:04,879 >> I WAS REFERRING TO THE NIDA 5918 05:16:04,945 --> 05:16:07,615 SUPPORTED MODERN FUTURE STUDY WE 5919 05:16:07,682 --> 05:16:09,350 HAVE A PROGRAM OFFICER TO ANSWER 5920 05:16:09,417 --> 05:16:15,856 BETTER THAN I CAN BUT THAT'S AN 5921 05:16:15,923 --> 05:16:21,062 ANNUAL SURVEY OF YOUTH IN 5922 05:16:21,128 --> 05:16:25,299 EIGHTH, NINTH AND 12th GRADE AND 5923 05:16:25,366 --> 05:16:26,767 COLLECTS INFORMATION ON A WIDE 5924 05:16:26,834 --> 05:16:29,203 RANGE OF DRUGS USED BY KIDS AS 5925 05:16:29,270 --> 05:16:32,273 WELL AS THEIR ATTITUDES AND 5926 05:16:32,340 --> 05:16:32,940 PERCEPTIONS OF DRUG USE AND 5927 05:16:33,007 --> 05:16:36,577 OTHER SOURCES OF DATA WE OFTEN 5928 05:16:36,644 --> 05:16:39,880 SITE ARE THE SURVEY ON DRUG USE 5929 05:16:39,947 --> 05:16:43,017 AND HEALTH SUPPORTED BY SAMHSA 5930 05:16:43,084 --> 05:16:47,021 AND USUALLY COMES OUT IN THE 5931 05:16:47,088 --> 05:16:48,189 FALL TIME AND HAS INFORMATION ON 5932 05:16:48,255 --> 05:16:49,657 CANNABIS USE. 5933 05:16:49,724 --> 05:16:52,226 I DON'T RECALL THE EXTENT TO IN 5934 05:16:52,293 --> 05:16:54,995 WHICH IT BREAKS DOWN TO 5935 05:16:55,062 --> 05:16:58,599 DIFFERENT KINDS OF CANNABINOIDS 5936 05:16:58,666 --> 05:17:04,138 AND BEYOND DELTA 8 I'M NOT SURE 5937 05:17:04,205 --> 05:17:05,139 BEYOND THAT WHAT IT DOES SO 5938 05:17:05,206 --> 05:17:07,842 MAYBE YOU WANT TO COMMENT. 5939 05:17:07,908 --> 05:17:10,277 >> THEY ADDED DELTA 8 FOR THE 5940 05:17:10,344 --> 05:17:11,512 FIRST TIME SINCE 2023 AND 5941 05:17:11,579 --> 05:17:14,715 THEY'RE SOCIOLOGISTS MOST OF 5942 05:17:14,782 --> 05:17:24,024 THEM AND IT'S AN EPIDEMIOLOGIC 5943 05:17:24,091 --> 05:17:25,259 STUDY AND HAVE A SCIENTIFIC 5944 05:17:25,326 --> 05:17:26,360 ADVISORY BOARD OR WHATEVER 5945 05:17:26,427 --> 05:17:28,028 THEY'RE CALLING IT THESE DAYS 5946 05:17:28,095 --> 05:17:29,663 WHO COMES AND MEETS ONCE A YEAR 5947 05:17:29,730 --> 05:17:31,165 AND TALK ABOUT ALL RIGHT THIS IS 5948 05:17:31,232 --> 05:17:32,400 WHAT WE'RE SEEING. 5949 05:17:32,466 --> 05:17:36,003 MAYBE YOU SHOULD CONSIDER ADDING 5950 05:17:36,070 --> 05:17:37,471 IT AND BALANCE GIVING IDEAS TO 5951 05:17:37,538 --> 05:17:38,339 CHILDREN ABOUT THINGS THEY 5952 05:17:38,406 --> 05:17:44,044 SHOULD USE VERSUS TRYING TO 5953 05:17:44,111 --> 05:17:47,715 CAPTURE INFORMATION THAT IS 5954 05:17:47,782 --> 05:17:53,354 GOING TO BE USEFUL AND THEY USED 5955 05:17:53,421 --> 05:17:54,688 THIS ON 12th GRADERS BECAUSE 5956 05:17:54,755 --> 05:17:57,658 THEY ADDED IT TO THE 2024 SURVEY 5957 05:17:57,725 --> 05:17:58,626 BECAUSE OF THE PREVALENCE AND 5958 05:17:58,692 --> 05:18:05,232 WE'LL HAVE IT FOR THE YOUNGER 5959 05:18:05,299 --> 05:18:07,001 STUDENTS BUT THEY EVALUATE 5960 05:18:07,067 --> 05:18:11,238 WHAT'S GOING ON AND DECIDE IT'S 5961 05:18:11,305 --> 05:18:15,075 A LARGE SURVEY SO ALL THE THINGS 5962 05:18:15,142 --> 05:18:17,778 THAT GO ALONG WITH A SURVEY. 5963 05:18:17,845 --> 05:18:21,315 SO AT ANY POINT THOSE WHO ARE 5964 05:18:21,382 --> 05:18:25,019 WORK IN COMMUNITIES, IF YOU SEE 5965 05:18:25,085 --> 05:18:27,588 SOMETHING GOING ON YOU THINK IS 5966 05:18:27,655 --> 05:18:30,524 PREVALENT THE INVESTIGATORS ARE 5967 05:18:30,591 --> 05:18:31,992 OPEN TO HAVING CONVERSATION 5968 05:18:32,059 --> 05:18:38,999 ABOUT WHAT SHOULD BE ADDED. 5969 05:18:39,066 --> 05:18:49,510 QUESTIONS FROM THE GROUP? 5970 05:18:51,479 --> 05:18:53,848 >> YOU MUST GO TO FDA TO HAVE TO 5971 05:18:53,914 --> 05:18:56,550 THE QUESTIONS ANSWERED AND 5972 05:18:56,617 --> 05:19:01,856 THEY'RE ALWAYS EXCITED TO DO SO 5973 05:19:01,922 --> 05:19:12,466 AND THEY OFTEN AND IT STARTS A 5974 05:19:17,271 --> 05:19:19,440 CONVERSATION BASICALLY ABOUT 5975 05:19:19,507 --> 05:19:25,179 WHETHER OR NOT IND DATA BUT I'VE 5976 05:19:25,246 --> 05:19:27,014 HEARD A THIRD OPTION WHICH IS 5977 05:19:27,081 --> 05:19:28,949 YOU AN FORMALLY REQUEST AN IND 5978 05:19:29,016 --> 05:19:38,192 WAIVER, IS THAT REAL OR NOT? 5979 05:19:38,259 --> 05:19:39,560 >> START WITH THE DIVISION AND 5980 05:19:39,627 --> 05:19:43,264 REACH OUT TO THEM AND ASK THEM 5981 05:19:43,330 --> 05:19:45,733 THEIR VIEW. 5982 05:19:45,799 --> 05:19:47,468 I'M WELL VERSED IN IND 5983 05:19:47,535 --> 05:19:48,135 EXCEPTIONS. 5984 05:19:48,202 --> 05:19:51,639 MY OPINION IS THEY'RE RARE BUT 5985 05:19:51,705 --> 05:19:52,606 WHETHER OR NOT YOU GET 90 GETS 5986 05:19:52,673 --> 05:19:55,009 TO BE COMPLICATED AS YOU MIGHT 5987 05:19:55,075 --> 05:19:58,579 EXPECT. 5988 05:19:58,646 --> 05:20:00,848 BECAUSE IT DEPENDS ON HOW A DRUG 5989 05:20:00,915 --> 05:20:02,216 OR COMPOUND IS USED. 5990 05:20:02,283 --> 05:20:05,252 GENERALLY DRUGS ARE DEFINED AS 5991 05:20:05,319 --> 05:20:08,923 CLAIMS ANYTHING INTENDED TO 5992 05:20:08,989 --> 05:20:10,558 MITIGATE OR TREAT DISEASE. 5993 05:20:10,624 --> 05:20:11,225 THERE'S LIKE FOUR OR FIVE WORDS 5994 05:20:11,292 --> 05:20:16,597 IN THERE. 5995 05:20:16,664 --> 05:20:18,265 THOSE ARE CONSIDERATIONS THE 5996 05:20:18,332 --> 05:20:19,700 AGENCY HAS IN ADDITION TO 5997 05:20:19,767 --> 05:20:22,903 WHETHER SOMEONE IS CLASSIFIED AS 5998 05:20:22,970 --> 05:20:33,480 A FOOD OR DIETARY SUPPLEMENT. 5999 05:20:35,149 --> 05:20:38,586 >> THERE'S A LOT OF INTEREST IN 6000 05:20:38,652 --> 05:20:40,220 THE MINOR CANNABINOIDS WITH 6001 05:20:40,287 --> 05:20:40,888 PRECLINICAL RESEARCH AND WHAT'S 6002 05:20:40,955 --> 05:20:43,657 IN THE CLEAR TO ME I THINK IT'S 6003 05:20:43,724 --> 05:20:44,224 AMBIGUOUS AND MAYBE CASE BY 6004 05:20:44,291 --> 05:20:51,832 CASE. 6005 05:20:51,899 --> 05:20:57,504 WHAT TYPE OF -- THOUGH IT MAY 6006 05:20:57,571 --> 05:21:00,307 NOT BE SUFFICIENT FOR NDA WHAT 6007 05:21:00,374 --> 05:21:01,175 PRECLINICAL TOX DATA THAT IS 6008 05:21:01,241 --> 05:21:03,010 EXISTING OR NEEDS TO BE 6009 05:21:03,077 --> 05:21:08,882 CONDUCTED THAT WOULD MEET A 6010 05:21:08,949 --> 05:21:14,088 MINIMUM STANDARD AND EXPLORATORY 6011 05:21:14,154 --> 05:21:15,155 PILOT AND CBC. 6012 05:21:15,222 --> 05:21:17,524 WHAT WOULD YOU GUYS LOOK FOR? 6013 05:21:17,591 --> 05:21:18,225 >> SURE. 6014 05:21:18,292 --> 05:21:20,561 THE TOXICOLOGY TEAM IS PROBABLY' 6015 05:21:20,628 --> 05:21:21,428 BETTER SOURCE TO ANSWER THAT 6016 05:21:21,495 --> 05:21:23,297 QUESTION BUT SOME OF THE 6017 05:21:23,364 --> 05:21:27,001 STANDARD ICH GUIDELINE THE 6018 05:21:27,067 --> 05:21:28,135 30-DAY, 60-DAY TOX STUDIES BUT 6019 05:21:28,202 --> 05:21:29,603 IT DEPENDS ON WHAT IS EXISTING 6020 05:21:29,670 --> 05:21:34,608 IN THE LITERATURE AS WELL. 6021 05:21:34,675 --> 05:21:36,510 IF YOU COULD COME IN AND 6022 05:21:36,577 --> 05:21:38,712 DEMONSTRATE WHAT YOU WANT TO 6023 05:21:38,779 --> 05:21:40,748 ADMINISTER IN YOUR CLINICAL 6024 05:21:40,814 --> 05:21:46,587 TRIAL WILL NOT EXPOSE SUBJECTS 6025 05:21:46,654 --> 05:21:49,657 TO RISK OR HARM BASED ON 6026 05:21:49,723 --> 05:21:50,991 EXISTING LITERATURE ARE THE CASE 6027 05:21:51,058 --> 05:21:52,059 BY CASE DECISIONS FDA MAKES. 6028 05:21:52,126 --> 05:21:56,430 >> THANKS VERY MUCH. 6029 05:21:56,497 --> 05:21:59,400 >> WITH THAT COULD THEY 6030 05:21:59,466 --> 05:22:01,001 POTENTIALLY CITE REFERENCES THAT 6031 05:22:01,068 --> 05:22:02,903 USE CANNABIS AS A WHOLE BUT 6032 05:22:02,970 --> 05:22:06,607 BEING ABLE TO SPECIFY THE AMOUNT 6033 05:22:06,674 --> 05:22:11,311 OF THE INDIVIDUAL CONSTITUENTS 6034 05:22:11,378 --> 05:22:13,614 AND WHAT THE DOSE IS IN THAT 6035 05:22:13,681 --> 05:22:15,015 RANGE IS THAT A POTENTIAL 6036 05:22:15,082 --> 05:22:16,617 REFERENCE THEY CAN LOOK AT? 6037 05:22:16,684 --> 05:22:19,319 >> ONE OF THE CHALLENGES I FOUND 6038 05:22:19,386 --> 05:22:22,990 WITH BOTANICAL PRODUCTS IS 6039 05:22:23,057 --> 05:22:24,925 ISOLATED COMPOUNDS VERSUS BULLET 6040 05:22:24,992 --> 05:22:25,292 POINT. 6041 05:22:25,359 --> 05:22:27,294 THE QUESTION IS NOW THAT YOU'VE 6042 05:22:27,361 --> 05:22:30,998 ISOLATED THAT VERY SPECIFIC 6043 05:22:31,065 --> 05:22:32,766 COMPOUND, HAVE YOU ELIMINATED 6044 05:22:32,833 --> 05:22:35,002 THE PROTECTIVE ENTOURAGE EFFECT 6045 05:22:35,069 --> 05:22:38,405 OR SOME OTHER EFFECT? 6046 05:22:38,472 --> 05:22:41,842 AND I WILL SAY I'VE RAN A STUDY 6047 05:22:41,909 --> 05:22:44,011 ON KRATOM WHICH I'M HAPPY TO 6048 05:22:44,078 --> 05:22:45,612 TALK ABOUT BUT WE RAN INTO 6049 05:22:45,679 --> 05:22:46,914 SIMILAR SITUATIONS LIKE THAT. 6050 05:22:46,980 --> 05:22:49,383 >> AND OFTEN TIMES WHEN YOU'RE 6051 05:22:49,450 --> 05:22:51,151 STUDYING A SINGLE COMPONENT, 6052 05:22:51,218 --> 05:22:53,887 YOU'RE USING IT IN HIGHER DOSES 6053 05:22:53,954 --> 05:22:59,126 THAN GIVEN OR TAKEN BY 6054 05:22:59,193 --> 05:23:01,695 INDIVIDUALS IN OTHER STUDIES 6055 05:23:01,762 --> 05:23:02,863 GIVING HIGHER DOSES. 6056 05:23:02,930 --> 05:23:07,000 >> AND DEPENDS ON THE STANDARD 6057 05:23:07,067 --> 05:23:10,037 DESIGN AND SOME HAVE MORE 6058 05:23:10,104 --> 05:23:10,704 CONFIDENCE IF YOU START LOW AND 6059 05:23:10,771 --> 05:23:16,610 GO UP. 6060 05:23:16,677 --> 05:23:19,413 YOU CAN SEE THEM INCREASE IN THE 6061 05:23:19,480 --> 05:23:21,749 DOSE-DEPENDENT MANNER. 6062 05:23:21,815 --> 05:23:22,616 HOPEFULLY YOU'LL HAVE SOME 6063 05:23:22,683 --> 05:23:32,926 SAFETY THERE. 6064 05:23:39,133 --> 05:23:42,736 >> THE FACT THAT IN THE 6065 05:23:42,803 --> 05:23:45,939 LEGISLATION I'M AWARE OF THERE'S 6066 05:23:46,006 --> 05:23:48,542 ALWAYS A DISTINCTION BEING MADE 6067 05:23:48,609 --> 05:23:52,646 BETWEEN NATURALLY DERIVED 6068 05:23:52,713 --> 05:23:56,550 CANNABINOIDS AND SYNTHETIC 6069 05:23:56,617 --> 05:23:56,884 CANNABINOIDS. 6070 05:23:56,950 --> 05:24:00,320 I DON'T MEAN MAN CANNABINOIDS 6071 05:24:00,387 --> 05:24:04,191 BUT THC MADE IN THE LAB OPPOSED 6072 05:24:04,258 --> 05:24:11,665 TO THC EXTRACTED FROM THE PLANT 6073 05:24:11,732 --> 05:24:13,500 AND CBC EXTRACTED FROM THE 6074 05:24:13,567 --> 05:24:14,168 PLANT. 6075 05:24:14,234 --> 05:24:15,469 IS THERE SOMETHING I DON'T KNOW? 6076 05:24:15,536 --> 05:24:22,176 ARE THEY REALLY DIFFERENT? 6077 05:24:22,242 --> 05:24:26,413 I WAS TALKING TO A GROUP OF 6078 05:24:26,480 --> 05:24:31,318 STAFFERS AND ONE PERSON RAISED 6079 05:24:31,385 --> 05:24:38,458 THEIR HAND AND SAID IS SYNTHETIC 6080 05:24:38,525 --> 05:24:40,427 THC DIFFERENT AND IT'S THE SAME 6081 05:24:40,494 --> 05:24:44,164 MOLECULE SO HOW CAN IT BE 6082 05:24:44,231 --> 05:24:44,431 DIFFERENT. 6083 05:24:44,498 --> 05:24:47,234 MY THOUGHT PROCESS IS THEY DON'T 6084 05:24:47,301 --> 05:24:49,703 KNOW. 6085 05:24:49,770 --> 05:24:51,905 IS THERE ANYTHING WE CAN DO TO 6086 05:24:51,972 --> 05:24:53,473 CONVINCE THEM THE MOLECULE IS 6087 05:24:53,540 --> 05:24:54,575 THE MOLECULE. 6088 05:24:54,641 --> 05:24:58,545 LIKE WATER IS WATER AND H2O AND 6089 05:24:58,612 --> 05:25:02,115 IT'S HOT OR COLD BUT IT'S WATER. 6090 05:25:02,182 --> 05:25:05,152 >> THERE'S A REAL NEED FOR 6091 05:25:05,219 --> 05:25:06,687 CLARITY AND EDUCATION OF POLICY 6092 05:25:06,753 --> 05:25:10,657 MAKERS AROUND SOME OF THIS STUFF 6093 05:25:10,724 --> 05:25:12,259 AND TO STEVE'S POINT THERE'S 6094 05:25:12,326 --> 05:25:13,894 OPPORTUNITIES FOR THE RESEARCH 6095 05:25:13,961 --> 05:25:16,163 COMMUNITY TO WEIGH IN ON RULE 6096 05:25:16,230 --> 05:25:16,396 MAKING. 6097 05:25:16,463 --> 05:25:18,232 WE CAN'T PROACTIVE GO TO 6098 05:25:18,298 --> 05:25:20,434 CONGRESS ON THESE THINGS BUT YOU 6099 05:25:20,500 --> 05:25:22,769 AS RESEARCHERS CERTAINLY CAN AND 6100 05:25:22,836 --> 05:25:25,873 I KNOW THERE ARE SCIENTIFIC 6101 05:25:25,939 --> 05:25:28,609 SOCIETIES THAT ARE INTERESTED IN 6102 05:25:28,675 --> 05:25:31,678 THESE QUESTIONS AND HAVE 6103 05:25:31,745 --> 05:25:36,350 ADVOCACY ARMS THAT ENGAGE WITH 6104 05:25:36,416 --> 05:25:40,621 CONGRESS ON THESE AND I'M 6105 05:25:40,687 --> 05:25:42,256 ENCOURAGING YOU TO REACH OUT 6106 05:25:42,322 --> 05:25:42,856 BECAUSE THERE'S OPPORTUNITIES 6107 05:25:42,923 --> 05:25:53,300 FOR EDUCATION ON THIS. 6108 05:25:55,302 --> 05:25:57,571 >> WERE HEMP DERIVED CBC 6109 05:25:57,638 --> 05:25:58,538 PRODUCTS SO THANK YOU. 6110 05:25:58,605 --> 05:26:00,607 AND MY QUESTION IS SAY MY 6111 05:26:00,674 --> 05:26:02,009 UNDERSTANDING IS IF I WERE TO 6112 05:26:02,075 --> 05:26:03,944 CONDUCT AN EXPERIMENTAL STUDY 6113 05:26:04,011 --> 05:26:06,580 FROM THE NIDA DRUG SUPPLY WITH 6114 05:26:06,647 --> 05:26:09,583 THE THC PRODUCT AND IT'S NOT ON 6115 05:26:09,650 --> 05:26:11,051 A THERAPEUTIC INDICATION BUT 6116 05:26:11,118 --> 05:26:12,786 MORE RISK OR ABUSE LIABILITY 6117 05:26:12,853 --> 05:26:13,086 PHENOTYPE. 6118 05:26:13,153 --> 05:26:14,154 IT'S AN EXPERIMENTAL STUDY. 6119 05:26:14,221 --> 05:26:18,191 I STILL HAVE TO GO TO THE FDA. 6120 05:26:18,258 --> 05:26:20,027 HOW DOES THE FDA CONSIDER THAT 6121 05:26:20,093 --> 05:26:22,629 IF I WERE TO DO AN ALCOHOL 6122 05:26:22,696 --> 05:26:24,765 ADMINISTRATION STUDY IN MY LAB 6123 05:26:24,831 --> 05:26:30,237 THAT IS PRETTY MUCH EXEMPT 6124 05:26:30,304 --> 05:26:31,004 RELATIVELY QUICKLY. 6125 05:26:31,071 --> 05:26:32,706 HOW DOES THE FDA TREAT THOSE 6126 05:26:32,773 --> 05:26:34,374 TYPES OF STUDIES AND ANY ADVICE 6127 05:26:34,441 --> 05:26:35,575 FOR INVESTIGATORS TRYING TO 6128 05:26:35,642 --> 05:26:38,478 NAVIGATE THAT? 6129 05:26:38,545 --> 05:26:39,146 >> YEAH. 6130 05:26:39,212 --> 05:26:44,751 I THINK THE EASIEST ANSWER IS 6131 05:26:44,818 --> 05:26:50,424 THC IS A DRUG SO THAT FALLS 6132 05:26:50,490 --> 05:26:53,160 UNDER THE FDA PURVIEW ARE OTHERS 6133 05:26:53,226 --> 05:26:53,827 MAY NOT. 6134 05:26:53,894 --> 05:26:56,697 >> ARE THERE TIMES STUDIES GET 6135 05:26:56,763 --> 05:26:57,798 EXEMPT CONSIDERING THEY'RE 6136 05:26:57,864 --> 05:27:01,168 EXPERIMENTAL STUDIES IN LAB 6137 05:27:01,234 --> 05:27:06,773 WITHOUT FOCUS ON A THERAPEUTIC 6138 05:27:06,840 --> 05:27:07,441 INDICATION? 6139 05:27:07,507 --> 05:27:12,079 OR IS THERE TYPICALLY THE GAMUT 6140 05:27:12,145 --> 05:27:13,280 FOR THE PROCESS. 6141 05:27:13,347 --> 05:27:14,514 >> THE OUTCOME MEASURES WOULD 6142 05:27:14,581 --> 05:27:22,622 PROBABLY BE A STRUCTURE 6143 05:27:22,689 --> 05:27:28,228 FUNCTION. 6144 05:27:28,295 --> 05:27:29,830 IT'S ADMINISTERING IS THE DRUG 6145 05:27:29,896 --> 05:27:33,300 TO SEE HOW IT AFFECTS THE 6146 05:27:33,367 --> 05:27:34,134 STRUCTURE FUNCTION. 6147 05:27:34,201 --> 05:27:38,138 >> AND THAT KEEPS IT UNDER THE 6148 05:27:38,205 --> 05:27:41,708 FDA PURVIEW? 6149 05:27:41,775 --> 05:27:43,610 >> IT PUTS IT INTO THE DRUG 6150 05:27:43,677 --> 05:27:46,446 TRIAL THAT REQUIRES 90 -- 6151 05:27:46,513 --> 05:27:49,216 >> CAN HAVE YOU THC-BASED 6152 05:27:49,282 --> 05:27:51,218 STUDIES THAT MEET THE CRITERIA 6153 05:27:51,284 --> 05:27:54,321 FOR EXEMPTION? 6154 05:27:54,388 --> 05:27:58,625 >> IF YOU HAVE AN FDA APPROVED 6155 05:27:58,692 --> 05:28:02,996 PRODUCT IN THE INDICATED 6156 05:28:03,063 --> 05:28:11,204 POPULATION -- YEAH. 6157 05:28:11,271 --> 05:28:19,012 >> WE FUND BOTANICALS AND THE 6158 05:28:19,079 --> 05:28:20,981 DIFFERENCE HERE IS THAT THIS SET 6159 05:28:21,048 --> 05:28:23,283 OF COMPOUNDS AND PRODUCT IS 6160 05:28:23,350 --> 05:28:27,788 CURRENTLY SCHEDULE 1 AND IN THE 6161 05:28:27,854 --> 05:28:29,322 PROCESS OF POTENTIALLY BEING 6162 05:28:29,389 --> 05:28:31,024 RESCHEDULED AND THE SAME PROCESS 6163 05:28:31,091 --> 05:28:33,260 COMES INTO PLAY WHERE WHAT YOUR 6164 05:28:33,326 --> 05:28:34,628 USING THE PRODUCT FOR IS THE 6165 05:28:34,694 --> 05:28:35,328 CONVERSATION I HAVE. 6166 05:28:35,395 --> 05:28:37,931 I WON'T GET ALL FIVE BUT TREAT, 6167 05:28:37,998 --> 05:28:38,999 MITIGATE, PREVENT, CURE OR 6168 05:28:39,066 --> 05:28:41,868 DIAGNOSIS. 6169 05:28:41,935 --> 05:28:43,637 ARE THE FIVE ARE -- IF YOU'RE 6170 05:28:43,703 --> 05:28:46,740 USING IT FOR ANY OF THOSE 6171 05:28:46,807 --> 05:28:49,976 REASONS, THEN WHETHER YOU PLAN 6172 05:28:50,043 --> 05:28:52,646 TO TAKE IT FORWARD FOR MARKETING 6173 05:28:52,712 --> 05:28:56,049 PURPOSES AND BRING IT TO AN NDA 6174 05:28:56,116 --> 05:28:56,750 SOMEONE ELSE WHEN YOU PUBLISH 6175 05:28:56,817 --> 05:28:59,052 THE RESULTS OF THAT WORK COULD 6176 05:28:59,119 --> 05:29:00,787 USE THAT INFORMATION TO MAKE AN 6177 05:29:00,854 --> 05:29:01,755 INDICATION IS HOW WE THINK ABOUT 6178 05:29:01,822 --> 05:29:11,898 IT. 6179 05:29:15,001 --> 05:29:17,771 THERE'S SOME ELEMENTS UNIQUE THE 6180 05:29:17,838 --> 05:29:19,940 HEMP DERIVED VERSUS NOT AND 6181 05:29:20,006 --> 05:29:21,208 FALLS IN THE BOTANICAL CATEGORY 6182 05:29:21,274 --> 05:29:23,110 AND ALL THE SAME RULES APPLY AS 6183 05:29:23,176 --> 05:29:33,553 ANY OTHER BOTANICALS. 6184 05:29:34,888 --> 05:29:37,657 >> DESCRIBE HOW THE BOTANICAL 6185 05:29:37,724 --> 05:29:38,825 AND DIVISION STAFF COORDINATE IN 6186 05:29:38,892 --> 05:29:43,029 AN IND REVIEW. 6187 05:29:43,096 --> 05:29:52,939 >> SURE. 6188 05:29:53,006 --> 05:29:59,846 >> IT'S A -- ASSIGNED WITH THE 6189 05:29:59,913 --> 05:30:02,015 DIVISION OF PSYCHIATRY AND 6190 05:30:02,082 --> 05:30:05,218 ANALGESIA AND ADDICTION PRODUCTS 6191 05:30:05,285 --> 05:30:08,054 AND DIVISION OF NEUROLOGY 6192 05:30:08,121 --> 05:30:09,189 PERHAPS AND THEY'LL PUT TOGETHER 6193 05:30:09,256 --> 05:30:11,324 A LARGE INTERNAL TEAM OF 6194 05:30:11,391 --> 05:30:12,359 INDIVIDUALS. 6195 05:30:12,425 --> 05:30:15,629 PHYSICIANS, CHEMISTS, 6196 05:30:15,695 --> 05:30:17,497 TOXICOLOGISTS, STATISTICIANS AND 6197 05:30:17,564 --> 05:30:20,567 CALL THE CONTROL SUBSTANCE STAFF 6198 05:30:20,634 --> 05:30:24,037 AS WELL AND GENERALLY THERE'S A 6199 05:30:24,104 --> 05:30:25,839 MEETING AND ANYWHERE FROM 15 TO 6200 05:30:25,906 --> 05:30:28,175 20 MULTI-DISCIPLINARY REVIEWERS 6201 05:30:28,241 --> 05:30:29,843 WILL SIT IN A ROOM AND SAY, 6202 05:30:29,910 --> 05:30:34,648 OKAY, HERE'S THE PROTOCOL. 6203 05:30:34,714 --> 05:30:38,818 WHAT DO WE THINK? 6204 05:30:38,885 --> 05:30:41,454 IT CAN RANGE FROM EVERYTHING 6205 05:30:41,521 --> 05:30:46,393 FROM SPLB SAW SOMETHING WORDED 6206 05:30:46,459 --> 05:30:48,929 FUNNY IN INFORMED CONSENT FORM 6207 05:30:48,995 --> 05:30:50,697 OR THE TEAM MAY NOTICE THE LEVEL 6208 05:30:50,764 --> 05:30:55,202 OF METAL IN HERE OR A LINE ITEM 6209 05:30:55,268 --> 05:30:56,770 THAT'S MISSING. 6210 05:30:56,836 --> 05:30:57,504 THE STATISTICAL TEAM MAY HAVE 6211 05:30:57,571 --> 05:31:00,974 QUESTIONS ABOUT THE STUDY 6212 05:31:01,041 --> 05:31:03,476 DESIGN, THE POWER, USUALLY THE 6213 05:31:03,543 --> 05:31:04,878 INITIAL MEETINGS DETERMINE 6214 05:31:04,945 --> 05:31:07,214 WHETHER THERE'S A HOLD ISSUE AND 6215 05:31:07,280 --> 05:31:12,619 HOLD ISSUES FT. LAUDERDALELY 6216 05:31:12,686 --> 05:31:18,358 SPEAKING ARE SAFETY. 6217 05:31:18,425 --> 05:31:19,626 AND THE PROTOCOL COULD BE PLACED 6218 05:31:19,693 --> 05:31:24,831 ON HOLD AND THE HOLD LETTER 6219 05:31:24,898 --> 05:31:25,932 DRAFTED IMMEDIATELY AND WE'RE 6220 05:31:25,999 --> 05:31:27,467 AWIRE WE ONLY HAVE 30 DAYS AND 6221 05:31:27,534 --> 05:31:29,636 GOES OUT AND WHEN THE RESPONSE 6222 05:31:29,703 --> 05:31:32,539 TO THE WHOLE COMES BACK IN TO 6223 05:31:32,606 --> 05:31:34,374 FDA SOMETIMES DEPENDING ON THE 6224 05:31:34,441 --> 05:31:39,512 ISSUE THE WHOLE GROUP WILL GET 6225 05:31:39,579 --> 05:31:41,881 BACK TOGETHER OR ONLY THE IS 6226 05:31:41,948 --> 05:31:45,485 SPECIFIC DISCIPLINE. 6227 05:31:45,552 --> 05:31:50,190 FROM A CSS PROSPECTIVE AND 6228 05:31:50,257 --> 05:31:51,725 CONTROLLED SUBSTANCES STAFF, 6229 05:31:51,791 --> 05:31:53,660 MARIJUANA, THC ARE ALL FROM OUR 6230 05:31:53,727 --> 05:31:55,795 PERSPECTIVE ARE ABUSE LIABILITY 6231 05:31:55,862 --> 05:32:01,501 IS PRETTY WELL CHARACTERIZED. 6232 05:32:01,568 --> 05:32:04,404 SO USUALLY CSS SPECIFICALLY 6233 05:32:04,471 --> 05:32:05,739 DOESN'T RAISE A LARGE AMOUNT OF 6234 05:32:05,805 --> 05:32:06,840 ISSUES. 6235 05:32:06,906 --> 05:32:08,074 OUR LANGUAGE IS WE WANT TO 6236 05:32:08,141 --> 05:32:09,876 NOTIFY YOU COULD BE USING A 6237 05:32:09,943 --> 05:32:12,145 SCHEDULE 1 SUBSTANCE AND AS OF 6238 05:32:12,212 --> 05:32:15,649 LATE OUR HEMP BILL OFTEN IT'S WE 6239 05:32:15,715 --> 05:32:17,050 GOT A SUBSTANCE OR PRODUCT THAT 6240 05:32:17,117 --> 05:32:20,053 LOOKS KIND OF FUNKY AND ON THE 6241 05:32:20,120 --> 05:32:21,521 .3% LINE SO TALK TO DEA AND SEE 6242 05:32:21,588 --> 05:32:25,425 IF YOU'RE SCHEDULED OR NOT. 6243 05:32:25,492 --> 05:32:28,194 BUT THAT'S GENERALLY HOW THE 6244 05:32:28,261 --> 05:32:30,463 PROCESS WORK AND FOR NDA THE 6245 05:32:30,530 --> 05:32:35,368 SIMILAR PROCESS AND OVER AND 6246 05:32:35,435 --> 05:32:45,912 OVER AGAIN FOR A YEAR LONG 6247 05:32:46,780 --> 05:32:47,280 REVIEW. 6248 05:32:47,347 --> 05:32:52,052 >> IS THERE A STANDARD FORMAT 6249 05:32:52,118 --> 05:32:53,553 AND THOUGHT FDA AND NIH CREATED 6250 05:32:53,620 --> 05:33:02,996 ONE TO MAKE IT EASIER TO DO 6251 05:33:03,063 --> 05:33:07,400 REVIEWS? 6252 05:33:07,467 --> 05:33:10,670 THEY ALL TEND TO LOOK DIFFERENT 6253 05:33:10,737 --> 05:33:12,238 TO MY EYE. 6254 05:33:12,305 --> 05:33:14,541 AFTER DOING IT SO LONG I START 6255 05:33:14,607 --> 05:33:16,676 TO RECOGNIZE SPECIFIC P.I.s BY 6256 05:33:16,743 --> 05:33:20,013 THEIR FONT AND LETTERHEAD. 6257 05:33:20,080 --> 05:33:22,115 SO IT'S GENERALLY NOT SUPER 6258 05:33:22,182 --> 05:33:25,318 STANDARDIZED BUT IT'S A CLINICAL 6259 05:33:25,385 --> 05:33:28,221 PROTOCOL SO GENERALLY SPEAKING 6260 05:33:28,288 --> 05:33:31,925 THEY HAVE THE INFORMATION YOU 6261 05:33:31,991 --> 05:33:32,959 EXPECT. 6262 05:33:33,026 --> 05:33:35,328 >> ANY OTHER ADVICE YOU HAVE FOR 6263 05:33:35,395 --> 05:33:36,129 RESEARCHERS OR OTHERS ONLINE 6264 05:33:36,196 --> 05:33:39,065 LISTENING IN AND WANTING TO DO 6265 05:33:39,132 --> 05:33:40,667 RESEARCH IN THIS SPACE. 6266 05:33:40,734 --> 05:33:51,244 >> I DON'T THINK I HAVE A LOT. 6267 05:33:58,418 --> 05:34:02,455 THE SCHEDULE 1 AND GOOGLE 1301.8 6268 05:34:02,522 --> 05:34:05,892 AND YOU'LL SEE BOLDED SECTIONS 6269 05:34:05,959 --> 05:34:07,794 THAT SAY, SCHEDULE 1 PROTOCOL 6270 05:34:07,861 --> 05:34:09,295 MUST CONTAIN -- NAME OF 6271 05:34:09,362 --> 05:34:12,065 INVESTIGATOR, AMOUNT USED, WHERE 6272 05:34:12,132 --> 05:34:16,302 YOU GOT IT FROM, SYNOPSIS OF THE 6273 05:34:16,369 --> 05:34:17,070 PROTOCOL, ETCETERA. 6274 05:34:17,137 --> 05:34:19,139 BY THE TIME WE GET THAT I 6275 05:34:19,205 --> 05:34:20,774 CREATED THIS WONDERFUL TEMPLATE 6276 05:34:20,840 --> 05:34:22,876 THAT OH, MY GOODNESS HAS THE 6277 05:34:22,942 --> 05:34:23,843 SAME HEADING. 6278 05:34:23,910 --> 05:34:27,046 WE LOOK AT THAT AND THE IND AND 6279 05:34:27,113 --> 05:34:28,715 PROTOCOLS GENERALLY REVIEWED BY 6280 05:34:28,782 --> 05:34:31,785 THE DIVISION BUT FOR THE 6281 05:34:31,851 --> 05:34:36,289 SCHEDULE 1 PORTION SPECIFICALLY, 6282 05:34:36,356 --> 05:34:37,924 CSS REVIEWS THOSE QUICKLY AND 6283 05:34:37,991 --> 05:34:39,025 GET IT BACK TO DEA AND WHAT 6284 05:34:39,092 --> 05:34:40,393 HAPPENS BEFORE THAT AND AFTER 6285 05:34:40,460 --> 05:34:50,470 THAT WE DON'T PARTICULARLY KNOW. 6286 05:34:50,537 --> 05:34:54,374 >> IF YOU HAVE QUESTIONS ABOUT 6287 05:34:54,441 --> 05:34:55,742 NAVIGATING THE PROCESS, DEA IS 6288 05:34:55,809 --> 05:34:57,677 YOUR BEST BET. 6289 05:34:57,744 --> 05:35:00,747 >> I WONDER IF ANYONE HAS AN 6290 05:35:00,814 --> 05:35:04,350 OPINION ON THE NINTH CIRCUIT'S 6291 05:35:04,417 --> 05:35:08,555 OPINION ON DELTA 8 AND AS A 6292 05:35:08,621 --> 05:35:09,322 PHARMACOLOGIST AND CHECKIST IT'S 6293 05:35:09,389 --> 05:35:11,891 WHAT DANIELE SAID THE COMPOUND 6294 05:35:11,958 --> 05:35:14,327 IS THE COMPOUND. 6295 05:35:14,394 --> 05:35:22,335 DELTA 8 IS PHARMACOLOGY EQU 6296 05:35:22,402 --> 05:35:26,172 EQUIVALENT AND ANY THOUGHTS ON 6297 05:35:26,239 --> 05:35:26,372 THAT? 6298 05:35:26,439 --> 05:35:28,608 >> THE PERSONAL THOUGHT IS A 6299 05:35:28,675 --> 05:35:32,479 MOLECULE IS A MOLECULE AND WHEN 6300 05:35:32,545 --> 05:35:36,216 YOU GET PLANT EXTRACTED OR 6301 05:35:36,282 --> 05:35:39,018 DERIVED AND ANY IMPURITIES ON 6302 05:35:39,085 --> 05:35:41,187 THE EXTRACTION ITSELF I DON'T 6303 05:35:41,254 --> 05:35:42,355 BELIEVE I'VE EVER SEEN EVIDENCE 6304 05:35:42,422 --> 05:35:50,597 AN EXTRACTED MOLECULE PERFORMS 6305 05:35:50,663 --> 05:35:52,065 DIFFERENT THAN A SYNTHETIC. 6306 05:35:52,131 --> 05:35:55,034 >> I'M NOT A PHARMACOLOGIST SO I 6307 05:35:55,101 --> 05:35:57,670 WON'T COMMENT. 6308 05:35:57,737 --> 05:35:59,038 >> THANK YOU SO MUCH TO OUR 6309 05:35:59,105 --> 05:36:00,206 SPEAKERS AND THE WONDERFUL 6310 05:36:00,273 --> 05:36:03,476 QUESTIONS AND I WILL INVITE INNA 6311 05:36:03,543 --> 05:36:04,477 UP TO MOVE US UP TO THE NEXT. 6312 05:36:04,544 --> 05:36:09,482 THANK YOU SO MUCH. 6313 05:36:09,549 --> 05:36:12,418 >> THANK YOU VERY MUCH FOR THE 6314 05:36:12,485 --> 05:36:15,054 SPEAKERS AND FOR THE MODERATORS. 6315 05:36:15,121 --> 05:36:16,322 I CAN'T BELIEVE IT BUT WE'RE AT 6316 05:36:16,389 --> 05:36:23,363 THE LAST SESSION OF TODAY. 6317 05:36:23,429 --> 05:36:25,265 WE HAVE SOME RESOURCES FROM FDA. 6318 05:36:25,331 --> 05:36:35,675 WONDERFUL RESOURCES. 6319 05:36:40,246 --> 05:36:42,582 AND TALK ABOUT THE OVERVIEW OF 6320 05:36:42,649 --> 05:36:43,983 NIH SUPPORT OF CANNABIS RESEARCH 6321 05:36:44,050 --> 05:36:45,518 AND INSTITUTE SPECIFIC 6322 05:36:45,585 --> 05:36:47,387 PRIORITIES AND I'LL INVITE 6323 05:36:47,453 --> 05:36:48,187 PROGRAM OFFICERS FROM OTHER 6324 05:36:48,254 --> 05:36:49,355 INSTITUTES AND CENTERS. 6325 05:36:49,422 --> 05:36:52,725 I THINK WE HAVE THREE IN THE 6326 05:36:52,792 --> 05:36:52,926 ROOM. 6327 05:36:52,992 --> 05:36:56,296 COULD YOU PLEASE JOIN THE 6328 05:36:56,362 --> 05:36:56,529 PODIUM. 6329 05:36:56,596 --> 05:37:01,334 SO AND YOUR NAMES SHOULD BE 6330 05:37:01,401 --> 05:37:02,035 HERE. 6331 05:37:02,101 --> 05:37:04,737 WE HAVE SEVERAL ON THE ZOOM 6332 05:37:04,804 --> 05:37:10,243 JOINING US AND WE HAVE THREE IN 6333 05:37:10,310 --> 05:37:13,346 THE ROOM. 6334 05:37:13,413 --> 05:37:17,350 WHEN YOU APPLY AND SUBMIT YOUR 6335 05:37:17,417 --> 05:37:22,956 APPLICATION TO NIH IT WILL GO TO 6336 05:37:23,022 --> 05:37:26,025 THE SPECIFIC INSTITUTE BASED ON 6337 05:37:26,092 --> 05:37:26,626 THE PRIORITIES AND MISSION OF 6338 05:37:26,693 --> 05:37:31,698 THE INSTITUTE. 6339 05:37:31,764 --> 05:37:36,202 SO I WILL START WITH NCCIH 6340 05:37:36,269 --> 05:37:37,870 INTERESTS AND THESE IS WHAT WE 6341 05:37:37,937 --> 05:37:38,037 GOT. 6342 05:37:38,104 --> 05:37:40,740 THE PURPOSE OF OUR PROGRAM THAT 6343 05:37:40,807 --> 05:37:42,508 IS CALLED CANNABIS RESEARCH 6344 05:37:42,575 --> 05:37:46,045 PROGRAM IS TO ENCOURAGE RESEARCH 6345 05:37:46,112 --> 05:37:50,149 ON TERPENES AND ORGANOIDS IN 6346 05:37:50,216 --> 05:37:51,851 ORGANISMS OR HUMAN SUBJECTS AS 6347 05:37:51,918 --> 05:37:54,721 IT RELATES TO PAIN, NOCICEPTION 6348 05:37:54,787 --> 05:38:05,598 AND AND AND GEE -- ANALGESIA AN 6349 05:38:05,665 --> 05:38:08,601 USE IT FOR PAIN RELIEF AND GOES 6350 05:38:08,668 --> 05:38:10,970 TO NATURAL PRODUCTS AN CANNABIS 6351 05:38:11,037 --> 05:38:13,606 CANNABINOID IS A NATURAL PRODUCT 6352 05:38:13,673 --> 05:38:13,940 INTERVENTION. 6353 05:38:14,007 --> 05:38:17,577 SO WE HAVE FOUR HIGH-PRIORITY 6354 05:38:17,644 --> 05:38:17,777 AREAS. 6355 05:38:17,844 --> 05:38:26,252 ONE AREA IS MECHANISMS BY WHICH 6356 05:38:26,319 --> 05:38:29,288 MINOR CANNABINOIDS AFFECT 6357 05:38:29,355 --> 05:38:33,559 SIGNALLING PASS WAY DURING 6358 05:38:33,626 --> 05:38:37,797 INTERACTIONS OR OTHER PATHWAYS. 6359 05:38:37,864 --> 05:38:40,033 THIS IS ONE BIG AREA AND THE 6360 05:38:40,099 --> 05:38:44,137 OTHER IS INTERACTION BETWEEN THE 6361 05:38:44,203 --> 05:38:46,739 MICROBIOME AND. 6362 05:38:46,806 --> 05:38:48,007 TERPENES. 6363 05:38:48,074 --> 05:38:51,711 THE THIRD IS HOW SPECIFIC 6364 05:38:51,778 --> 05:38:54,047 TERPENES MAY INFLUENCE POTENTIAL 6365 05:38:54,113 --> 05:38:57,050 ANALGESIC MECHANISMS OF UNDER 6366 05:38:57,116 --> 05:38:58,751 STUDIED MINOR CANNABINOIDS AND 6367 05:38:58,818 --> 05:39:04,657 NUMBER FOUR, MULTIMODAL 6368 05:39:04,724 --> 05:39:06,492 APPROACHES TO ANALGESIA 6369 05:39:06,559 --> 05:39:09,028 INCLUDING MINOR CANNABINOIDS AND 6370 05:39:09,095 --> 05:39:09,796 TERPENES. 6371 05:39:09,862 --> 05:39:15,034 THE GOAL IS TO BRING EXPERTISE 6372 05:39:15,101 --> 05:39:21,607 FROM MANY AREAS AND FACILITATE 6373 05:39:21,674 --> 05:39:23,810 COLLABORATIONS BY EXPERTS AND 6374 05:39:23,876 --> 05:39:25,511 IMMUNOLOGY AND CHEMISTRY AND 6375 05:39:25,578 --> 05:39:26,112 PAIN AND NEUROSCIENCE. 6376 05:39:26,179 --> 05:39:29,882 THIS IS NCCH PROGRAM ON 6377 05:39:29,949 --> 05:39:34,520 CANNABINOIDS AND PAIN. 6378 05:39:34,587 --> 05:39:35,888 WE PUBLISHED THE NOTICE OF 6379 05:39:35,955 --> 05:39:37,590 SPECIAL INTEREST AND PROMOTE 6380 05:39:37,657 --> 05:39:39,692 MECHANISTIC RESEARCH OF 6381 05:39:39,759 --> 05:39:41,661 THERAPEUTIC AND OTHER BIOLOGICAL 6382 05:39:41,728 --> 05:39:47,467 PROPERTIES OF THERAPISTS 6383 05:39:47,533 --> 05:39:51,838 TOGETHER WITH 10 INSTITUTES AND 6384 05:39:51,904 --> 05:39:55,041 CENTERS OF NIH SO AUTHOR DEFINED 6385 05:39:55,108 --> 05:40:00,079 AS COMBINES FROM THE CANNABIS 6386 05:40:00,146 --> 05:40:03,783 PLANT OTHER THAN THC AND MAY 6387 05:40:03,850 --> 05:40:09,355 INCLUDE MANY THAT WERE DISCUSSED 6388 05:40:09,422 --> 05:40:14,961 TODAY SUCH AS OTHERS. 6389 05:40:15,027 --> 05:40:18,498 THIS NOTICE OF SPECIFIC INTEREST 6390 05:40:18,564 --> 05:40:21,768 SUPPORT HIGHLY INNOVATIVE BASIC 6391 05:40:21,834 --> 05:40:24,871 AND MECHANISTIC STUDIES AND 6392 05:40:24,937 --> 05:40:26,339 HUMAN SUBJECTS AIMING TO 6393 05:40:26,405 --> 05:40:30,676 INVESTIGATE THE IMPACT OF MINOR 6394 05:40:30,743 --> 05:40:32,845 CANNABINOIDS ON MECHANISMS 6395 05:40:32,912 --> 05:40:34,981 UNDERLYING THE THERAPEUTIC 6396 05:40:35,047 --> 05:40:38,584 EFFECTS. 6397 05:40:38,651 --> 05:40:45,558 SO THE NOSI IS BUT CLINICAL 6398 05:40:45,625 --> 05:40:48,261 STUDIES ARE ENCOURAGED FOR 6399 05:40:48,327 --> 05:40:50,096 COMBINATIONS OF MINOR 6400 05:40:50,163 --> 05:40:52,398 CANNABINOIDS OR OTHER NATURAL 6401 05:40:52,465 --> 05:40:57,837 PRODUCTS SUCH AS KRATOM THAT MAY 6402 05:40:57,904 --> 05:41:01,040 ENHANCE THE THERAPEUTIC BENEFITS 6403 05:41:01,107 --> 05:41:03,776 OR ADVERSE EFFECT AFFECT. 6404 05:41:03,843 --> 05:41:07,013 THE EXPIRATION DATE IS JULY 1, 6405 05:41:07,079 --> 05:41:07,947 2025. 6406 05:41:08,014 --> 05:41:10,316 SO IN THIS WE HAVE MANY 6407 05:41:10,383 --> 05:41:11,851 INSTITUTIONS AND THE NEXT ONE 6408 05:41:11,918 --> 05:41:15,021 WILL BE MY COLLEAGUE FROM THE 6409 05:41:15,087 --> 05:41:25,498 NATIONAL EYE INSTITUTE. 6410 05:41:38,778 --> 05:41:46,819 ONE OF THE PROPERTIES IS STUDIES 6411 05:41:46,886 --> 05:41:48,955 AND SEE THE PROGRAM AT THE 6412 05:41:49,021 --> 05:41:53,993 NATIONAL EYE INSTITUTE AND 6413 05:41:54,060 --> 05:42:04,470 PROVIDED THIS SLIDE AND 6414 05:42:05,271 --> 05:42:08,474 CANNABINOIDS FOR GLAUCOMA AND 6415 05:42:08,541 --> 05:42:15,014 DRY EYE AND DIABETIC ON THES AND 6416 05:42:15,081 --> 05:42:15,848 THE PRIORITIES FOR THE NATIONAL 6417 05:42:15,915 --> 05:42:21,621 EYE INSTITUTE. 6418 05:42:21,687 --> 05:42:22,755 OKAY. 6419 05:42:22,822 --> 05:42:29,161 NEXT ONE I WELCOME THE DIVISION 6420 05:42:29,228 --> 05:42:32,899 OF RESEARCH NATIONAL INSTITUTE 6421 05:42:32,965 --> 05:42:33,833 OF MENTAL HEALTH. 6422 05:42:33,900 --> 05:42:34,400 >> GOOD AFTERNOON, THREW SO 6423 05:42:34,467 --> 05:42:38,638 MUCH. 6424 05:42:38,704 --> 05:42:40,539 -- THANK YOU SO MUCH. 6425 05:42:40,606 --> 05:42:42,508 IT LOOKS LIKE THE SLIDE NEEDS TO 6426 05:42:42,575 --> 05:42:44,076 BE CLICKED MULTIPLE TIMES. 6427 05:42:44,143 --> 05:42:46,812 I'M THE BRANCH CHIEF IN ONE OF 6428 05:42:46,879 --> 05:42:57,423 THE EXTRAMURAL DIVISIONS OF T 6429 05:43:00,159 --> 05:43:01,627 THEIBILITY NATIONAL INSTITUTE OF 6430 05:43:01,694 --> 05:43:05,431 MENTAL HEALTH AND LOOK AT HOW 6431 05:43:05,498 --> 05:43:06,632 ENDOGENOUS CANNABINOIDS 6432 05:43:06,699 --> 05:43:10,136 INFLUENCE CIRCUIT BASED 6433 05:43:10,202 --> 05:43:14,774 MECHANISM AND IMPLICATE MENTAL 6434 05:43:14,840 --> 05:43:16,976 HEALTH BEHAVIORS AND TESTING 6435 05:43:17,043 --> 05:43:23,816 TARGETING ACTING ON THIS SYSTEM. 6436 05:43:23,883 --> 05:43:27,453 THE PRECLINICAL RESEARCH WOULD 6437 05:43:27,520 --> 05:43:29,422 NOT STUDY MARIJUANA AND 6438 05:43:29,488 --> 05:43:31,023 COMPOUNDS IN PRE-CLINICAL 6439 05:43:31,090 --> 05:43:31,290 RECEIVER. 6440 05:43:31,357 --> 05:43:33,292 IN THE AREA OF CLINICAL 6441 05:43:33,359 --> 05:43:35,661 RESEARCH, THE FOCUS WOULD BE ON 6442 05:43:35,728 --> 05:43:38,631 STUDYING HOW PHARMACOLOGIC 6443 05:43:38,698 --> 05:43:40,766 MANIPULATION OF CANNABINOID OR 6444 05:43:40,833 --> 05:43:42,468 CANNABINOID RECEPTORS CAN 6445 05:43:42,535 --> 05:43:43,869 INFLUENCE FUNCTION OF THE 6446 05:43:43,936 --> 05:43:45,237 CENTRAL NERVOUS SYSTEM 6447 05:43:45,304 --> 05:43:46,839 SPECIFICALLY IN PSYCHIATRIC 6448 05:43:46,906 --> 05:43:50,476 DISORDERS AND THE CAUSE OF THE 6449 05:43:50,543 --> 05:43:58,617 TARGET-BASED ORIENTATION OF OUR 6450 05:43:58,684 --> 05:44:02,154 CLINICAL TRIAL SYSTEM THAT WOULD 6451 05:44:02,221 --> 05:44:05,624 READ TO THE ACCESS OF THE 6452 05:44:05,691 --> 05:44:09,595 PHARMACOLOGIC AGENTS WITH 6453 05:44:09,662 --> 05:44:12,431 SPECIFICITY AND TEST EARLY STAGE 6454 05:44:12,498 --> 05:44:15,034 PHARMACO KINETIC TRIALS USING 6455 05:44:15,101 --> 05:44:20,706 TRIAL DESIGNS THAT INCORPORATE A 6456 05:44:20,773 --> 05:44:22,875 CENTRAL NERVOUS SYSTEM AND 6457 05:44:22,942 --> 05:44:27,580 ASSOCIATED WITH THE 6458 05:44:27,646 --> 05:44:29,448 PRE-SPECIFIED PHARMACOLOGIC 6459 05:44:29,515 --> 05:44:29,682 TARGET. 6460 05:44:29,749 --> 05:44:31,884 THAT'S IT. 6461 05:44:31,951 --> 05:44:35,121 >> THANK YOU VERY MUCH. 6462 05:44:35,187 --> 05:44:39,258 NOW WE'RE MOVING TO DR. YU AT 6463 05:44:39,325 --> 05:44:42,128 THE DIVISION OF METASCIENCE AND 6464 05:44:42,194 --> 05:44:44,363 BEHAVIOR OF THE NATIONAL 6465 05:44:44,430 --> 05:44:46,632 INSTITUTE OF ALCOHOL ABUSE AND 6466 05:44:46,699 --> 05:44:46,932 ALCOHOLISM. 6467 05:44:46,999 --> 05:44:52,838 NO. 6468 05:44:52,905 --> 05:44:55,374 I THINK I HAVE THE WRONG ORDER 6469 05:44:55,441 --> 05:44:59,011 TE NEXT PRESENTER IS DR. LIN 6470 05:44:59,078 --> 05:45:00,246 FROM NIDA. 6471 05:45:00,312 --> 05:45:04,884 >> I'M HAPPY TO OPPORTUNITY TO 6472 05:45:04,950 --> 05:45:07,887 COME HERE AND FOLLOW MY 6473 05:45:07,953 --> 05:45:08,687 COLLEAGUE'S PREVIOUS 6474 05:45:08,754 --> 05:45:12,124 PRESENTATIONS AND NIDA IS NOT A 6475 05:45:12,191 --> 05:45:12,725 STRANGER TO THE AUDIENCE HERE 6476 05:45:12,792 --> 05:45:16,295 TODAY. 6477 05:45:16,362 --> 05:45:22,068 WHAT I'D LIKE TO SAY IS THAT 6478 05:45:22,134 --> 05:45:23,502 MANY PRESENTATIONS HERE 6479 05:45:23,569 --> 05:45:26,572 INCLUDING WILL WHAT INNA 6480 05:45:26,639 --> 05:45:28,407 DESCRIBED ABOUT THE NCCIH 6481 05:45:28,474 --> 05:45:29,642 PRIORITY WE SHARE THE SAME 6482 05:45:29,708 --> 05:45:30,242 INTEREST, FOR EXAMPLE PAIN 6483 05:45:30,309 --> 05:45:34,880 RESEARCH AS THE MAIN TOPIC OF 6484 05:45:34,947 --> 05:45:35,781 TODAY'S SYMPOSIUM AND SHOWED 6485 05:45:35,848 --> 05:45:37,683 INTEREST IN TERMS OF IMMUNOLOGY 6486 05:45:37,750 --> 05:45:44,623 AND IN TERMS OF THE NEUROIMMIMM 6487 05:45:44,690 --> 05:45:54,300 INTERACTS AND IN NYE -- NIDA 6488 05:45:54,366 --> 05:45:58,871 AND IN TERMS OF CANNABINOID WE 6489 05:45:58,938 --> 05:46:04,376 DID RESEARCH FOR 10 YEARS NOW. 6490 05:46:04,443 --> 05:46:06,846 WHAT I WANT TO POINT OUT THE 6491 05:46:06,912 --> 05:46:11,984 DIVISION OF NEUROSCIENCE AND 6492 05:46:12,051 --> 05:46:20,559 BEHAVIOR WE FOCUS ON BRAIN 6493 05:46:20,626 --> 05:46:25,364 INTERACTIONS AND WE LIST SEVERAL 6494 05:46:25,431 --> 05:46:26,732 PRIORITIES LIKE NOSIs MORE 6495 05:46:26,799 --> 05:46:28,734 SPECIFIC AND THESE ARE EXAMPLES. 6496 05:46:28,801 --> 05:46:29,802 EVERY YEAR WE HAVE THE 6497 05:46:29,869 --> 05:46:35,107 OPPORTUNITY TO DEVELOP NEW IDEAS 6498 05:46:35,174 --> 05:46:40,946 AND YOU'LL SEE NEW INITIATIVES 6499 05:46:41,013 --> 05:46:42,515 COME OUT. 6500 05:46:42,581 --> 05:46:46,719 SOME HAVE ACTIVE IN THERE AND 6501 05:46:46,785 --> 05:46:50,623 EVEN FOR THOSE NOT EXPIRED AND 6502 05:46:50,689 --> 05:46:54,560 I'D ENCOURAGE YOU TO LOOK TO THE 6503 05:46:54,627 --> 05:46:57,530 IF THE AREA AS TO YOUR INTEREST 6504 05:46:57,596 --> 05:47:02,902 THE REASON IS FOR THE NOSI AND 6505 05:47:02,968 --> 05:47:07,406 NOFO, THOSE MECHANISM FOR NIH TO 6506 05:47:07,473 --> 05:47:12,211 SHARE WITH YOU THE PROGRAM 6507 05:47:12,278 --> 05:47:18,417 IDENTIFIED SO EVERY YEAR WE PUT 6508 05:47:18,484 --> 05:47:28,994 SEVERAL NEW BUT FOR THOSE TO 6509 05:47:29,228 --> 05:47:31,030 YOUR AREA OF INTEREST AND LOOK 6510 05:47:31,096 --> 05:47:38,037 TO THAT AND YOU CAN CONTINUE TO 6511 05:47:38,103 --> 05:47:43,876 SHARE INTEREST WITH NCCIH AND 6512 05:47:43,943 --> 05:47:49,582 INTEREST WITH NIDA AND WE WORK 6513 05:47:49,648 --> 05:47:59,024 WITH NCCIH AND SHARE THE 6514 05:47:59,091 --> 05:48:05,130 PERSPECTIVES OF NCCIH WE WORK 6515 05:48:05,197 --> 05:48:13,405 CLOSELY TOGETHER AND IF YOU HAVE 6516 05:48:13,472 --> 05:48:14,306 QUESTIONS WORK WITH US. 6517 05:48:14,373 --> 05:48:17,876 >> I'M PLEASED TO INTRODUCE 6518 05:48:17,943 --> 05:48:19,979 DR. OSHINSKY PROGRAM DIRECTOR 6519 05:48:20,045 --> 05:48:23,015 FROM NINDS. 6520 05:48:23,082 --> 05:48:27,253 >> I'M THE DIRECTOR THE OFFICE 6521 05:48:27,319 --> 05:48:30,723 OF PRECLINICAL PAIN RESEARCH AT 6522 05:48:30,789 --> 05:48:34,893 NINDS AND HAVE A CENTRAL ROLE IN 6523 05:48:34,960 --> 05:48:37,429 MANAGING THE PAIN PORTION OF THE 6524 05:48:37,496 --> 05:48:39,198 HEAL INITIATIVE. 6525 05:48:39,265 --> 05:48:40,532 NINDS' ROLE IS NOT FOCUSSED ON 6526 05:48:40,599 --> 05:48:42,801 THE CANNABINOID ITSELF BUT 6527 05:48:42,868 --> 05:48:44,370 REALLY ON THE THERAPEUTIC 6528 05:48:44,436 --> 05:48:46,905 CONDITIONS AND PATHOLOGICAL 6529 05:48:46,972 --> 05:48:50,576 CONDITIONS THAT FALL IN NINDS' 6530 05:48:50,643 --> 05:48:52,911 MISSION AND THERE'S EPILEPSY, 6531 05:48:52,978 --> 05:48:55,214 ALZHEIMER'S DISEASE, ALS, 6532 05:48:55,281 --> 05:49:00,619 PARKINSON'S DISEASE AND PAIN AND 6533 05:49:00,686 --> 05:49:02,254 HEADACHE AND WE'VE HAD 6534 05:49:02,321 --> 05:49:07,059 APPLICATIONS COME IN FOR 6535 05:49:07,126 --> 05:49:08,727 CANNABINOID RESEARCH AND 6536 05:49:08,794 --> 05:49:10,863 RESEARCH FOR THE THERAPEUTIC 6537 05:49:10,929 --> 05:49:11,163 CONDITIONS. 6538 05:49:11,230 --> 05:49:15,034 THERE'S A FEW OTHER POINTS I 6539 05:49:15,100 --> 05:49:17,670 WANT TO MAKE. 6540 05:49:17,736 --> 05:49:19,438 I WATCHED THE PRESENTATIONS 6541 05:49:19,505 --> 05:49:22,241 EARLIER TODAY AND THE DATA 6542 05:49:22,308 --> 05:49:23,542 BLITZ' AND THERE'S GREAT WORK ON 6543 05:49:23,609 --> 05:49:25,544 HERE. 6544 05:49:25,611 --> 05:49:26,178 THERE'S RESTRICTED AMOUNT OF 6545 05:49:26,245 --> 05:49:29,982 TYPE OF WORK THAT CAN HAPPEN 6546 05:49:30,049 --> 05:49:31,450 INSIDE OF AN R&R 21 AND 6547 05:49:31,517 --> 05:49:34,386 ENCOURAGE YOU TO 6548 05:49:34,720 --> 05:49:41,293 AN R21 AND NOT THERE'S LY -- 6549 05:49:41,360 --> 05:49:43,028 THERE'S NOT NECESSARILY LOOK FOR 6550 05:49:43,095 --> 05:49:46,899 THE WORD CANNABINOID AND IF IT'S 6551 05:49:46,965 --> 05:49:48,400 IN NINDS' MISSION IT DOESN'T 6552 05:49:48,467 --> 05:49:50,269 HAVE TO HAVE A FUNDING 6553 05:49:50,336 --> 05:49:51,637 ANNOUNCEMENT TO LIST 6554 05:49:51,704 --> 05:49:53,906 CANNABINOIDS TO PUT IT ON THE 6555 05:49:53,972 --> 05:49:54,406 PARENT R01. 6556 05:49:54,473 --> 05:49:57,242 I WANT TO ENCOURAGE YOU TO DO 6557 05:49:57,309 --> 05:49:58,277 THAT. 6558 05:49:58,344 --> 05:50:00,612 THE SECOND THING IS AT NINDS AND 6559 05:50:00,679 --> 05:50:02,348 THIS IS A TRANS-NIH PROGRAM BUT 6560 05:50:02,414 --> 05:50:03,882 CAU IN SEE THEN ON THE WEBSITE 6561 05:50:03,949 --> 05:50:06,185 WE SUPPORT THE USE OF THE DATA 6562 05:50:06,251 --> 05:50:07,986 TRANSPARENCY AND RIGOR ICONS. 6563 05:50:08,053 --> 05:50:12,624 I WAS SURPRISED THERE WERE FEW 6564 05:50:12,691 --> 05:50:15,661 DOSE RESPONSES DONE IN THE 6565 05:50:15,728 --> 05:50:17,996 ANIMALS, DESCRIPTION OF THE 6566 05:50:18,063 --> 05:50:20,766 BLINDING, WHAT THE 6567 05:50:20,833 --> 05:50:21,367 INCLUSION/EXCLUSION CRITERIA 6568 05:50:21,433 --> 05:50:23,802 WERE AND I UNDERSTAND THE R21 6569 05:50:23,869 --> 05:50:30,008 IT'S TOUGH TO DO THAT BUT INSIDE 6570 05:50:30,075 --> 05:50:33,846 THE R01s MAY GIVE RIGOR ASPECT 6571 05:50:33,912 --> 05:50:36,315 FOR THE RESEARCH AND WE HAVE THE 6572 05:50:36,382 --> 05:50:37,149 DIVISION OF TRANSLATIONAL 6573 05:50:37,216 --> 05:50:41,086 RESEARCH TO HELP YOU AND WE HAVE 6574 05:50:41,153 --> 05:50:43,088 SEVERAL PROGRAMS NOT R01 6575 05:50:43,155 --> 05:50:45,124 MECHANISMS AND MILESTONE 6576 05:50:45,190 --> 05:50:48,260 MECHANISMS TO HELP YOU WITH YOUR 6577 05:50:48,327 --> 05:50:51,029 IND SUBMISSION AND PHASE 1 6578 05:50:51,096 --> 05:50:55,067 CLINICAL TRIALS AND HAVE A SLEW 6579 05:50:55,134 --> 05:51:00,272 OF NET FOR DISORDERS AND ONE IS 6580 05:51:00,339 --> 05:51:07,179 FOR PAIN AND THE OTHER IS 6581 05:51:07,246 --> 05:51:08,580 NEURONEXT AND ENCOURAGE YOU TO 6582 05:51:08,647 --> 05:51:10,916 USE THEM FOR YOUR CANNABINOID 6583 05:51:10,983 --> 05:51:15,120 RESEARCH. 6584 05:51:15,187 --> 05:51:18,190 THAT'S THE MISSION OF THE 6585 05:51:18,257 --> 05:51:21,093 TRANSLATIONAL RESEARCH WHICH IS 6586 05:51:21,160 --> 05:51:26,632 WHERE INSIDE OF NINDS WE HAVE 6587 05:51:26,698 --> 05:51:28,467 THE CLINICAL RESEARCH THAT RUNS 6588 05:51:28,534 --> 05:51:30,469 THE CLINICAL TRIAL NETWORKSES 6589 05:51:30,536 --> 05:51:31,703 AND REACH OUT IF YOU HAVE 6590 05:51:31,770 --> 05:51:35,808 QUESTIONS HOW TO TAKE ADVANTAGE 6591 05:51:35,874 --> 05:51:37,342 OF NINDS' FUNDING ANNOUNCEMENT 6592 05:51:37,409 --> 05:51:38,677 OR HAVE AN IDEA FOR A PROJECT 6593 05:51:38,744 --> 05:51:40,913 INSIDE THE MISSION. 6594 05:51:40,979 --> 05:51:41,980 HAPPY TO ENTERTAIN THAT. 6595 05:51:42,047 --> 05:51:42,448 AGAIN, GREAT MEETING. 6596 05:51:42,514 --> 05:51:46,919 THANK YOU. 6597 05:51:46,985 --> 05:51:48,720 >> THANK YOU, MICHAEL. 6598 05:51:48,787 --> 05:51:49,588 THIS IS GREAT. 6599 05:51:49,655 --> 05:51:55,260 NOW I INVITE MY COLLEAGUE FROM 6600 05:51:55,327 --> 05:52:00,466 THE NIAA ALCOHOL APEWS AND 6601 05:52:00,532 --> 05:52:04,403 ALCOHOLISM INSTITUTE, DR. LIU. 6602 05:52:04,470 --> 05:52:08,106 >> GOOD AFTERNOON. 6603 05:52:08,173 --> 05:52:10,342 MY NAME IS QI-YING LIU AT THE 6604 05:52:10,409 --> 05:52:12,945 DIVISION OF NEUROSCIENCE AND 6605 05:52:13,011 --> 05:52:14,379 BEHAVIOR NATIONAL INSTITUTE ON 6606 05:52:14,446 --> 05:52:22,921 ALCOHOL ABUSE AND ALCOHOLISM. 6607 05:52:22,988 --> 05:52:24,923 NIAAA. 6608 05:52:24,990 --> 05:52:29,294 SUBSTANCE USE DISORDER INSTITUTE 6609 05:52:29,361 --> 05:52:35,834 IS FOCUS ON ALCOHOL USE DISORDER 6610 05:52:35,901 --> 05:52:39,705 AND WE'RE INTERESTED IN 6611 05:52:39,771 --> 05:52:41,507 COMORBIDITY AND LOOKING AT 6612 05:52:41,573 --> 05:52:45,511 STUDIES RELEVANT TO THIS MEETING 6613 05:52:45,577 --> 05:52:47,946 SUCH AS THE AFFECT OF CANNABIS 6614 05:52:48,013 --> 05:52:49,481 USE ON ALCOHOL CRAVING AND 6615 05:52:49,548 --> 05:52:54,987 CONSUMPTION AND THE STUDY OF PRE 6616 05:52:55,053 --> 05:52:58,357 NATAL ALCOHOL EXPOSURE AND FETAL 6617 05:52:58,423 --> 05:52:58,857 BRAIN DEVELOPMENT. 6618 05:52:58,924 --> 05:53:02,094 SO NIAAA'S PORTFOLIO IN THIS 6619 05:53:02,160 --> 05:53:04,930 AREA IS QUITE SMALL WITH LESS 6620 05:53:04,997 --> 05:53:15,040 THAN 10 ACTIVE RESEARCH FINDS. 6621 05:53:15,107 --> 05:53:17,943 A 6622 05:53:18,010 --> 05:53:21,280 AND CANNABIS EXPERTS AND WE 6623 05:53:21,346 --> 05:53:27,052 EXPLORE THE ROLE OF 6624 05:53:27,119 --> 05:53:31,089 ENDOCANNABINOID RECEPTORS IN 6625 05:53:31,156 --> 05:53:36,428 ALCOHOL MISUSE AND AUD. 6626 05:53:36,495 --> 05:53:38,297 NIAAA'S PRIORITY IN THIS AREA 6627 05:53:38,363 --> 05:53:43,468 INCLUDE RESEARCH EXPLORING THE 6628 05:53:43,535 --> 05:53:46,939 ROLE OF CANNABINOID MISUSE AND 6629 05:53:47,005 --> 05:53:52,578 TO STUDY MECHANISMS OF 6630 05:53:52,644 --> 05:53:53,245 CANNABINOID AND ALCOHOL 6631 05:53:53,312 --> 05:53:56,148 PREFERENCE AND CONSUMPTION AND 6632 05:53:56,214 --> 05:53:58,951 INTOXICATION AND WITHDRAWAL AND 6633 05:53:59,017 --> 05:54:03,088 ETCETERA. 6634 05:54:03,155 --> 05:54:06,425 SECONDLY, WE'RE INTERESTED IN 6635 05:54:06,491 --> 05:54:10,929 EXPLORING THE SIGNAL SYSTEM AS 6636 05:54:10,996 --> 05:54:13,198 POTENTIAL TARGETS FOR ALCOHOL 6637 05:54:13,265 --> 05:54:18,937 PHARMACO THERAPY AND DEVELOP 6638 05:54:19,004 --> 05:54:21,640 MEDICATIONS FOR AUD MEDICATED BY 6639 05:54:21,707 --> 05:54:26,778 THE RECEPTORS. 6640 05:54:26,845 --> 05:54:31,750 SO WE'RE INTERESTED IN THE 6641 05:54:31,817 --> 05:54:35,787 POTENTIAL FOR USING CBD FOR THE 6642 05:54:35,854 --> 05:54:41,026 TREATMENT OF AUD AND LASTLY 6643 05:54:41,093 --> 05:54:43,595 STATUS IN EX MORGUE BRAIN 6644 05:54:43,662 --> 05:54:47,532 MECHANISMS SHARED BY ALCOHOL USE 6645 05:54:47,599 --> 05:54:51,903 DISORDER AND OTHER SUBSTANCE USE 6646 05:54:51,970 --> 05:54:54,039 DISORDERS INCLUDING CANNABIS USE 6647 05:54:54,106 --> 05:54:56,141 AS SUPPORTED BY NIAA. 6648 05:54:56,208 --> 05:54:58,977 I'LL STOP THERE. 6649 05:54:59,044 --> 05:55:01,813 >> THANK YOU. 6650 05:55:01,880 --> 05:55:04,383 THANK YOU, DR. LIU, GREAT. 6651 05:55:04,449 --> 05:55:07,019 THE NEXT PRESENTER IS 6652 05:55:07,085 --> 05:55:17,329 DR. FREEDMAN. 6653 05:55:19,798 --> 05:55:20,832 >> I'M FROM THE NATIONAL CANCER 6654 05:55:20,899 --> 05:55:21,099 INSTITUTE. 6655 05:55:21,166 --> 05:55:23,568 THERE WAS A STUDY FROM 6656 05:55:23,635 --> 05:55:26,805 WASHINGTON STATE SHOWING 1 IN 4 6657 05:55:26,872 --> 05:55:28,140 CANCER PATIENTS WERE USING 6658 05:55:28,206 --> 05:55:30,208 CANNABIS OR CANNABINOID DURING 6659 05:55:30,275 --> 05:55:30,642 TREATMENT. 6660 05:55:30,709 --> 05:55:36,348 SO NCI TOOK NOTICE AND DEVELOPED 6661 05:55:36,415 --> 05:55:37,916 THE CANCER RESEARCH GROUP ACROSS 6662 05:55:37,983 --> 05:55:43,055 ALL OF NCI AND CO-LEAD THIS AND 6663 05:55:43,121 --> 05:55:45,857 OUR GOALS ARE TO ASSESS CANCER 6664 05:55:45,924 --> 05:55:47,059 PATIENT'S USE OF CANNABIS AND 6665 05:55:47,125 --> 05:55:49,194 IDENTIFY BENEFITS AND HARMS AND 6666 05:55:49,261 --> 05:55:52,497 LOOK AT TOBACCO CO-USE AND LOOK 6667 05:55:52,564 --> 05:55:54,232 AT THE ACTION IN CANCER AND 6668 05:55:54,299 --> 05:55:55,767 CONTRIBUTE EVIDENCE TO 6669 05:55:55,834 --> 05:55:57,302 CLINICIANS AND PATIENTS AND 6670 05:55:57,369 --> 05:55:59,638 PROVIDE INFORMATION DESIGN AND 6671 05:55:59,705 --> 05:56:01,506 CONDUCT CLINICAL TRIALS. 6672 05:56:01,573 --> 05:56:03,642 FIRST THING WE DID WAS DEVELOP A 6673 05:56:03,709 --> 05:56:05,677 SYMPOSIUM IN 2020 THAT I THINK 6674 05:56:05,744 --> 05:56:11,550 WAS A TWO OR THREE-DAY SYMPOSIUM 6675 05:56:11,616 --> 05:56:13,185 AND WERE ABLE TO PUBLISH A YEAR 6676 05:56:13,251 --> 05:56:14,586 LATER WITH THE HIGHLIGHTS FROM 6677 05:56:14,653 --> 05:56:16,288 THE SYMPOSIUM AND USED IT TO 6678 05:56:16,354 --> 05:56:16,822 IDENTIFY THE GAPS IN THE 6679 05:56:16,888 --> 05:56:18,990 RESEARCH. 6680 05:56:19,057 --> 05:56:22,828 AT THE SAME TIME WE WERE ABLE TO 6681 05:56:22,894 --> 05:56:24,396 FUND COMPREHENSIVE CANCER 6682 05:56:24,463 --> 05:56:26,698 CENTERS TO DO A CROSS-SECTIONAL 6683 05:56:26,765 --> 05:56:29,000 SURVEY OF THE THOUSAND CANCER 6684 05:56:29,067 --> 05:56:30,469 PATIENTS ON THEIR USE OF 6685 05:56:30,535 --> 05:56:33,105 CANNABIS, HOW THEY USE IT AND 6686 05:56:33,171 --> 05:56:34,539 WHY AND DO THEY THINK IT MAKES A 6687 05:56:34,606 --> 05:56:37,075 DIFFERENCE AND WE'RE JUST ABOUT 6688 05:56:37,142 --> 05:56:40,645 TO PUBLISH ANOTHER MONOGRAPH IN 6689 05:56:40,712 --> 05:56:42,914 GNCI WITH ABOUT 14 ARTICLES 6690 05:56:42,981 --> 05:56:44,082 BASED ON THE RESULTS. 6691 05:56:44,149 --> 05:56:46,218 THOSE RESULTS RIGHT NOW ARE 6692 05:56:46,284 --> 05:56:48,353 SHOWING THAT IT'S NOT 1 IN 4 6693 05:56:48,420 --> 05:56:52,724 CANCER PATIENTS BUT 1 IN 3 USE 6694 05:56:52,791 --> 05:56:55,026 CANNABIS DURING THEIR TREATMENT. 6695 05:56:55,093 --> 05:56:58,263 WE DEVELOPED A FEW INITIATIVES. 6696 05:56:58,330 --> 05:56:59,464 ONE IS ADMINISTRATIVE SUPPLEMENT 6697 05:56:59,531 --> 05:57:04,269 LOOKING AT TOBACCO AND CANNABIS 6698 05:57:04,336 --> 05:57:04,503 CO-USE. 6699 05:57:04,569 --> 05:57:06,438 WE HAVE A NOTICE OF SPECIAL 6700 05:57:06,505 --> 05:57:10,375 INTEREST OR NOSI STILL ACTIVE ON 6701 05:57:10,442 --> 05:57:13,211 BASIC MECHANISM OF CANNABIS IN 6702 05:57:13,278 --> 05:57:15,580 CANCER AND LAST YEAR WE WERE 6703 05:57:15,647 --> 05:57:20,485 ABLE TO FUND AN RFA ON CANNABIS 6704 05:57:20,552 --> 05:57:22,187 AND CANNABINOID USE ON ADULT 6705 05:57:22,254 --> 05:57:23,188 PATIENTS DURING ACTIVE TREATMENT 6706 05:57:23,255 --> 05:57:25,757 AND BENEFITS AND HARMS. 6707 05:57:25,824 --> 05:57:31,196 WE FUNDED FIVE CANCER CANNABIS 6708 05:57:31,263 --> 05:57:31,429 COHORTS. 6709 05:57:31,496 --> 05:57:33,965 ALL COHORTS WILL LOOK AT 6710 05:57:34,032 --> 05:57:34,833 PATIENTS IN THE ACT MUCH 6711 05:57:34,900 --> 05:57:37,536 TREATMENT AND LOOKING AT THOSE 6712 05:57:37,602 --> 05:57:40,105 USING CANNABIS AND NOT USING 6713 05:57:40,172 --> 05:57:40,405 CANNABIS. 6714 05:57:40,472 --> 05:57:42,874 IN TOTAL WE'LL HAVE OVER 4,000 6715 05:57:42,941 --> 05:57:45,944 CANCER PATIENTS AND WE'LL BE 6716 05:57:46,011 --> 05:57:48,046 FOLLOWING THEM FOR UP TO TWO OR 6717 05:57:48,113 --> 05:57:49,548 THREE YEARS. 6718 05:57:49,614 --> 05:57:51,383 SO HOPEFULLY WITH THIS RFA WE'LL 6719 05:57:51,449 --> 05:57:52,884 GET EVIDENCE ON SOME BENEFITS 6720 05:57:52,951 --> 05:57:54,653 AND HARMS AND NOT JUST 6721 05:57:54,719 --> 05:57:55,020 CROSS-SECTIONAL. 6722 05:57:55,086 --> 05:57:56,521 SO IF YOU HAVE ANY QUESTIONS 6723 05:57:56,588 --> 05:57:58,423 ABOUT ANYTHING WE'RE FUNDING, OR 6724 05:57:58,490 --> 05:57:59,257 ANYTHING WE'RE DOING, PLEASE 6725 05:57:59,324 --> 05:58:01,193 FEEL FREE TO CONTACT ME OR JOE 6726 05:58:01,259 --> 05:58:01,827 AT ANY TIME. 6727 05:58:01,893 --> 05:58:02,060 THANKS. 6728 05:58:02,127 --> 05:58:06,965 >> THANK YOU VERY MUCH. 6729 05:58:07,032 --> 05:58:15,006 AND NOW OUR FINAL PRESENTER, I'D 6730 05:58:15,073 --> 05:58:17,042 LIKE TO INTRODUCE ONE MORE SLIDE 6731 05:58:17,108 --> 05:58:23,014 AND THIS IS FROM MY COLLEAGUE 6732 05:58:23,081 --> 05:58:30,655 DR. ALEXIS BACKOS COULDN'T JOIN 6733 05:58:30,722 --> 05:58:36,294 US BUT WANTED ME TO SHOW HER 6734 05:58:36,361 --> 05:58:37,495 SLIDE ON THE NATIONAL INSTITUTE 6735 05:58:37,562 --> 05:58:40,465 OF AGING AND LOOKING AT THE 6736 05:58:40,532 --> 05:58:43,001 POTENTIAL CONTRIBUTIONS OR 6737 05:58:43,068 --> 05:58:45,570 ADVERSE OF CANNABINOIDS TO 6738 05:58:45,637 --> 05:58:47,472 RELIEF SYMPTOMS AND IMPROVE 6739 05:58:47,539 --> 05:58:51,843 QUALITY OF LIFE IN OLDER ADULTS 6740 05:58:51,910 --> 05:58:55,046 EXPERIENCING PAIN, AGE-RELATED 6741 05:58:55,113 --> 05:59:02,087 COGNITIVE DECLINE AND INSOMNIA 6742 05:59:02,153 --> 05:59:04,589 AND FOR END OF LIFE CARE. 6743 05:59:04,656 --> 05:59:07,025 SO IF YOU HAVE ANY INTEREST IN 6744 05:59:07,092 --> 05:59:11,663 THOSE AREAS, PLEASE CONTACT HER 6745 05:59:11,730 --> 05:59:11,963 DIRECTLY. 6746 05:59:12,030 --> 05:59:15,367 AND FINALLY, WE HAVE A PRESENTER 6747 05:59:15,433 --> 05:59:21,840 IN THE ROOM, DR. LORENA 6748 05:59:21,907 --> 05:59:26,811 BACCAGLINI AT THE CENTER FOR 6749 05:59:26,878 --> 05:59:27,579 CLINICAL RESEARCH, NATIONAL 6750 05:59:27,646 --> 05:59:29,314 INSTITUTE OF DENTAL AND 6751 05:59:29,381 --> 05:59:29,814 CRANIOFACIAL RESEARCH. 6752 05:59:29,881 --> 05:59:32,083 >> YOU ALREADY GAVE SUCH A GOOD 6753 05:59:32,150 --> 05:59:33,551 PRESENTATION SO MY TWO MINUTES I 6754 05:59:33,618 --> 05:59:40,458 MAY ONLY NEED ONE MINUTE. 6755 05:59:40,525 --> 05:59:42,093 I'M HERE FOR THE NATIONAL 6756 05:59:42,160 --> 05:59:43,561 INSTITUTE OF DENTAL AND 6757 05:59:43,628 --> 05:59:44,562 CRANIOFACIAL RESEARCH. 6758 05:59:44,629 --> 05:59:49,734 I'M THE DIRECTOR OF THE CLINICAL 6759 05:59:49,801 --> 05:59:52,437 RESEARCH AND EPIDEMIOLOGICAL 6760 05:59:52,504 --> 05:59:54,039 PROGRAM AND WE'VE BEEN WORKING 6761 05:59:54,105 --> 05:59:57,742 WITH INNA AND THIS IS AN EXAMPLE 6762 05:59:57,809 --> 06:00:01,980 OF THE TYPE OF COLLABORATION WE 6763 06:00:02,047 --> 06:00:11,022 HAVE WITH OUR OTHER COLLEAGUES. 6764 06:00:11,089 --> 06:00:17,429 AND IF YOU HAVE AN INTEREST IN 6765 06:00:17,495 --> 06:00:21,933 THE DENTAL CRANIOFACIAL OUTCOMES 6766 06:00:22,000 --> 06:00:26,137 COME TO OUR INSTITUTE AND THE 6767 06:00:26,204 --> 06:00:30,775 CANNABINOID RECEPTOR SPREAD 6768 06:00:30,842 --> 06:00:41,386 THROUGHOUT THE AREA AND WE FIND 6769 06:00:46,925 --> 06:00:51,529 IT IN THE TEMPORAL MANDIBULAR 6770 06:00:51,596 --> 06:00:55,033 JOINT AND CONSIDER IDEAS IN THAT 6771 06:00:55,100 --> 06:01:02,173 AND THE STUDIES FOR THIS FUNDING 6772 06:01:02,240 --> 06:01:09,114 OPPORTUNITY COULD BE PRECHIN -- 6773 06:01:09,180 --> 06:01:11,316 PRE CLINICAL AND MECHANISTIC 6774 06:01:11,383 --> 06:01:14,319 STUDIES AND STUDY ANALGESIA BUT 6775 06:01:14,386 --> 06:01:19,457 ALSO IMMUNE EFFECT AND 6776 06:01:19,524 --> 06:01:23,028 ANTIINFLAMMATORY AND OTHER 6777 06:01:23,094 --> 06:01:31,436 THERAPEUTIC THOUGHTS. 6778 06:01:31,503 --> 06:01:35,006 AS LONG AS IT'S DENTAL OR 6779 06:01:35,073 --> 06:01:36,141 CRANIOFACIAL YOU CAN CONSIDER 6780 06:01:36,207 --> 06:01:36,474 THESE. 6781 06:01:36,541 --> 06:01:37,375 AS OTHER COLLEAGUES HAVE 6782 06:01:37,442 --> 06:01:41,012 MENTIONED YOU DON'T HAVE TO GO 6783 06:01:41,079 --> 06:01:44,682 THROUGH A PARTICULAR FUNDING 6784 06:01:44,749 --> 06:01:46,051 OPPORTUNITY BUT YOU CAN APPLY 6785 06:01:46,117 --> 06:01:47,986 THE GENERAL MECHANISMS. 6786 06:01:48,053 --> 06:01:53,024 IF YOU'RE THINKING ABOUT AN 6787 06:01:53,091 --> 06:01:54,826 OBSERVATIONAL OR BASIC SCIENCE 6788 06:01:54,893 --> 06:01:59,431 STUDY YOU CAN APPLY THROUGH THE 6789 06:01:59,497 --> 06:02:01,800 REGULAR R01 OR R21 MECHANISMS 6790 06:02:01,866 --> 06:02:11,009 THEY'RE AVAILABLE ALL THE TIME. 6791 06:02:11,076 --> 06:02:14,879 YOU CAN KEEP AN EYE ON THE NOSI 6792 06:02:14,946 --> 06:02:17,115 EXPIRED BUT IF IT'S NOT RENEWED 6793 06:02:17,182 --> 06:02:19,217 YOU CAN APPLY THROUGH THE 6794 06:02:19,284 --> 06:02:21,519 GENERAL MECHANISMS. 6795 06:02:21,586 --> 06:02:24,923 IF YOU'RE THINKING OF AN 6796 06:02:24,989 --> 06:02:26,558 INTERVENTIONAL TYPE OF STUDY YOU 6797 06:02:26,624 --> 06:02:32,163 WOULD APPLY THROUGH THE UH3 -- 6798 06:02:32,230 --> 06:02:36,501 UG3, UH3 MECHANISM WHERE THERE'S 6799 06:02:36,568 --> 06:02:38,303 AN INITIAL PHASE WHERE YOU 6800 06:02:38,369 --> 06:02:40,839 DEVELOP THE COMPONENTS AND THE 6801 06:02:40,905 --> 06:02:41,606 UG3 WHERE YOU DO THE 6802 06:02:41,673 --> 06:02:42,073 IMPLEMENTATION OF THE 6803 06:02:42,140 --> 06:02:45,076 INTERVENTION. 6804 06:02:45,143 --> 06:02:47,011 AND IF YOU HAVE ANY QUESTIONS, 6805 06:02:47,078 --> 06:02:53,017 FEEL FREE TO CONTACT ME OR MY 6806 06:02:53,084 --> 06:02:57,222 COLLEAGUE THE DIRECTOR OF THE 6807 06:02:57,288 --> 06:02:58,089 NEUROSCIENCE AND TEMPORAL 6808 06:02:58,156 --> 06:02:59,624 MANDIBULAR DISORDER PROGRAM AND 6809 06:02:59,691 --> 06:03:01,526 WE'LL BE HAPPY TO SPEAK WITH YOU 6810 06:03:01,593 --> 06:03:07,031 AND ANSWER ANY QUESTIONS. 6811 06:03:07,098 --> 06:03:09,167 >> THANK YOU. 6812 06:03:09,234 --> 06:03:15,006 THANK YOU, SO MUCH LORENA. 6813 06:03:15,073 --> 06:03:16,441 WE'RE A LITTLE BIT BEHIND FOR 6814 06:03:16,508 --> 06:03:19,277 THE Q&A DO WE HAVE BURNING 6815 06:03:19,344 --> 06:03:20,545 QUESTION FROM ZOOM OR IN THE 6816 06:03:20,612 --> 06:03:21,079 ROOM? 6817 06:03:21,146 --> 06:03:23,781 IF YOU HAVE ANY QUESTIONS WE CAN 6818 06:03:23,848 --> 06:03:26,117 ACCOMMODATE ONE OR TWO, IF NOT 6819 06:03:26,184 --> 06:03:27,785 YOU HAVE THE CONTACT INFORMATION 6820 06:03:27,852 --> 06:03:34,092 AND PLEASE DO NOT HESITATE TO 6821 06:03:34,159 --> 06:03:35,293 FIND THE PROGRAM OFFICER AND YOU 6822 06:03:35,360 --> 06:03:37,762 KNOW THIS IS THE KEY FOR 6823 06:03:37,829 --> 06:03:37,996 SUCCESS. 6824 06:03:38,062 --> 06:03:38,863 OKAY. 6825 06:03:38,930 --> 06:03:40,899 SO THANK YOU SO MUCH TO MY 6826 06:03:40,965 --> 06:03:42,901 WONDERFUL COLLEAGUES. 6827 06:03:42,967 --> 06:03:51,009 OF COURSE THIS IS WE CAN DO THIS 6828 06:03:51,075 --> 06:03:53,044 RESEARCH TOGETHER. 6829 06:03:53,111 --> 06:03:57,916 THANK YOU SO MUCH. 6830 06:03:57,982 --> 06:04:00,518 NOW I'D LIKE TO WELCOME 6831 06:04:00,585 --> 06:04:01,119 DR. SHURTLEFF FOR THE CLOSING 6832 06:04:01,186 --> 06:04:08,626 REMARKS. 6833 06:04:08,693 --> 06:04:10,628 >> FIRST, I WANT TO SAY WHAT A 6834 06:04:10,695 --> 06:04:11,496 GREAT DAY IT WAS. 6835 06:04:11,563 --> 06:04:13,798 IT'S GREAT TO SEE EVERYBODY IN 6836 06:04:13,865 --> 06:04:16,701 PERSON AFTER FOUR OR FIVE LONG 6837 06:04:16,768 --> 06:04:17,368 YEARS OF DEALING WITH COVID AND 6838 06:04:17,435 --> 06:04:20,138 OTHER THINGS. 6839 06:04:20,205 --> 06:04:22,540 AND TAKE LONG VIEW OF THIS WE'VE 6840 06:04:22,607 --> 06:04:25,777 COME A LONG WAY AS AN INSTITUTE 6841 06:04:25,843 --> 06:04:27,011 WE DIDN'T HAVE A CANNABIS 6842 06:04:27,078 --> 06:04:28,046 RESEARCH PROGRAM FIVE YEARS AGO 6843 06:04:28,112 --> 06:04:32,917 AND NOW HAVE A BURGEONING 6844 06:04:32,984 --> 06:04:33,484 GROWING DEVELOPING PROGRAM. 6845 06:04:33,551 --> 06:04:35,019 A LOT MORE TO DO. 6846 06:04:35,086 --> 06:04:36,354 YOU LAID THE FOUNDATION FOR 6847 06:04:36,421 --> 06:04:41,392 SOMETHING REALLY IMPORTANT WE 6848 06:04:41,459 --> 06:04:44,596 STARTED NOW AND CANNABIS IS A 6849 06:04:44,662 --> 06:04:47,031 MANUFACTURING MACHINE OF A 6850 06:04:47,098 --> 06:04:50,401 VARIETY OF NATURAL PRODUCTS AND 6851 06:04:50,468 --> 06:04:54,772 CANNABINOIDS AND TERPENES AND 6852 06:04:54,839 --> 06:04:55,573 OTHER CHEMICALS THE PLANT 6853 06:04:55,640 --> 06:04:57,642 PROVIDES A WEALTH OF OPPORTUNITY 6854 06:04:57,709 --> 06:04:59,244 TO DEVELOP AND THC GOT US HERE 6855 06:04:59,310 --> 06:05:04,816 BUT I THINK THC NEEDS TO BE PUT 6856 06:05:04,882 --> 06:05:06,417 ASIDE AND FOCUS ON OTHER 6857 06:05:06,484 --> 06:05:07,852 COMPOUNDS THAT MAY HAVE 6858 06:05:07,919 --> 06:05:08,653 POTENTIAL THERAPEUTIC BENEFIT AS 6859 06:05:08,720 --> 06:05:10,989 WE LEARNED OVER THE LAST FOUR OR 6860 06:05:11,055 --> 06:05:14,459 FIVE YEARS ACTUALLY WITH YOUR 6861 06:05:14,525 --> 06:05:14,726 GOOD WORK. 6862 06:05:14,792 --> 06:05:17,862 SO I'D LIKE TO ALSO THANK OUR 6863 06:05:17,929 --> 06:05:18,630 NIH COLLEAGUES. 6864 06:05:18,696 --> 06:05:21,833 I THINK THIS IS A TEAM EFFORT 6865 06:05:21,899 --> 06:05:24,802 NOT JUST NCCIH BUT ALL OF NIH 6866 06:05:24,869 --> 06:05:26,838 THAT NEEDS TO GET ON BOARD AND 6867 06:05:26,904 --> 06:05:28,139 MAKING PROGRESS IN THAT DOMAIN 6868 06:05:28,206 --> 06:05:31,809 AS YOU HEARD FROM THE LAST PANEL 6869 06:05:31,876 --> 06:05:33,911 AND CERTAINLY THROUGH OUR 6870 06:05:33,978 --> 06:05:35,647 PROGRAM WE'RE MAKING GREAT 6871 06:05:35,713 --> 06:05:36,781 STRIDES TO INCLUDE EVERYONE IN 6872 06:05:36,848 --> 06:05:39,550 THE TO FURTHER RESEARCH FUNDING 6873 06:05:39,617 --> 06:05:41,853 AND OPPORTUNITIES FOR STUDYING 6874 06:05:41,919 --> 06:05:45,390 MINOR CANNABINOIDS AND OTHER 6875 06:05:45,456 --> 06:05:46,724 ASPECTS OF THE CANNABIS PLANT 6876 06:05:46,791 --> 06:05:47,525 FOR THERAPEUTIC DEVELOPMENT 6877 06:05:47,592 --> 06:05:50,128 ACROSS A WIDE RANGE OF 6878 06:05:50,194 --> 06:05:53,264 CONDITIONS NOT JUST PAIN AND 6879 06:05:53,331 --> 06:05:56,834 ANALGESIA AND MANY CONDITIONS AS 6880 06:05:56,901 --> 06:05:58,002 YOU LEARNED FROM MY COLLEAGUES 6881 06:05:58,069 --> 06:05:59,170 ACROSS NIH AND THAT WILL 6882 06:05:59,237 --> 06:06:00,204 CONTINUE TO GROW. 6883 06:06:00,271 --> 06:06:02,073 I THINK WE LEARNED A LOT WHERE 6884 06:06:02,140 --> 06:06:04,909 THE NEXT STEPS TO BE. 6885 06:06:04,976 --> 06:06:06,344 PHARMACO GENETICS CAME UP AND 6886 06:06:06,411 --> 06:06:07,545 ARTIFICIAL INTELLIGENCE AND 6887 06:06:07,612 --> 06:06:08,980 OTHER NEW TECHNOLOGIES THAT 6888 06:06:09,047 --> 06:06:12,250 COULD BE BROUGHT TO BEAR TO 6889 06:06:12,317 --> 06:06:18,523 STUDY CANNABINOIDS IS WE'LL TAKE 6890 06:06:18,589 --> 06:06:20,491 SERIOUSLY AS WE THINK OF NEXT 6891 06:06:20,558 --> 06:06:22,593 STEPS AT NIH. 6892 06:06:22,660 --> 06:06:28,166 AND THANK YOU AGAIN FOR SPELT 6893 06:06:28,232 --> 06:06:33,037 US -- SETTING US UP AND THANK 6894 06:06:33,104 --> 06:06:36,174 YOU INNA BELFER WHO ORGANIZED 6895 06:06:36,240 --> 06:06:37,141 THE MEETING. 6896 06:06:37,208 --> 06:06:39,010 SHE HAS A DAY JOB. 6897 06:06:39,077 --> 06:06:41,112 THESE ALSO A PROGRAM OFFICER AND 6898 06:06:41,179 --> 06:06:43,047 NOT A MEETING ORGANIZER SO THANK 6899 06:06:43,114 --> 06:06:48,653 YOU INNA AND THE NIH STAFF THAT 6900 06:06:48,720 --> 06:06:50,688 HELPED SUPPORT THIS EFFORT 6901 06:06:50,755 --> 06:06:53,191 INCLUDING CERTAINLY THE P.I.s 6902 06:06:53,257 --> 06:06:55,059 AND THE GENEROUS CONTRIBUTIONS 6903 06:06:55,126 --> 06:06:59,397 AND RESEARCH AND IDEAS, THE NIH 6904 06:06:59,464 --> 06:07:01,833 I.C.s AND FDA. 6905 06:07:01,899 --> 06:07:03,568 WE COULDN'T DO IT WITHOUT FDA. 6906 06:07:03,634 --> 06:07:07,004 THANK YOU, FDA. 6907 06:07:07,071 --> 06:07:10,341 YOU PLAY AN IMPORTANT ROLE AND 6908 06:07:10,408 --> 06:07:12,310 D.A. AND WE KNOW THE ROLE THEY 6909 06:07:12,377 --> 06:07:13,811 PLAY IN HELPING REGULATE THE 6910 06:07:13,878 --> 06:07:15,413 RESEARCH WE DO AND PLAY AN 6911 06:07:15,480 --> 06:07:18,383 IMPORTANT ROLE IN ALL THAT. 6912 06:07:18,449 --> 06:07:22,553 SPECIAL THANKS TO NIH STAFF WHO 6913 06:07:22,620 --> 06:07:24,122 ORGANIZED AND RAN THE MEETING. 6914 06:07:24,188 --> 06:07:26,691 THE PEOPLE BEHIND THE SCENES. 6915 06:07:26,758 --> 06:07:31,028 MANY PEOPLE DIDN'T SEE AND 6916 06:07:31,095 --> 06:07:41,606 DR. PETERSON AND THE OVERVIEW. 6917 06:07:42,974 --> 06:07:47,111 I HOPE YOU ENJOYED COMING TO THE 6918 06:07:47,178 --> 06:07:47,445 NIH. 6919 06:07:47,512 --> 06:07:49,647 I HOPE YOU HAD FUN AND FOUND 6920 06:07:49,714 --> 06:07:51,449 OPPORTUNITIES TO SPEAK TO FELLOW 6921 06:07:51,516 --> 06:07:53,217 COLLEAGUES AND HAVE A FEW 6922 06:07:53,284 --> 06:07:54,085 COLLABORATIONS STARTED BECAUSE 6923 06:07:54,152 --> 06:07:55,086 OF THIS MEETING. 6924 06:07:55,153 --> 06:07:56,587 WE ALWAYS LIKE TO SEE THAT 6925 06:07:56,654 --> 06:07:56,821 HAPPEN. 6926 06:07:56,888 --> 06:07:58,256 IF YOU HAVE QUESTIONS YOU KNOW 6927 06:07:58,322 --> 06:08:00,425 WHERE TO FIND ME AND INNA AND 6928 06:08:00,491 --> 06:08:02,994 ALL OUR GREAT STAFF, PATRICK AND 6929 06:08:03,060 --> 06:08:07,231 WENDY AND CRAIG AND EVERYONE 6930 06:08:07,298 --> 06:08:11,002 INVOLVED IN THE CANNABIS PROGRAM 6931 06:08:11,068 --> 06:08:14,071 AT NCCIH AND FIND COLLEAGUES AT 6932 06:08:14,138 --> 06:08:16,107 NIDA AND OTHER PLACES. 6933 06:08:16,174 --> 06:08:18,609 I HOPE YOU'LL KEEP IN TOUCH AND 6934 06:08:18,676 --> 06:08:20,678 LOOK FORWARD TO THE FUTURE OF 6935 06:08:20,745 --> 06:08:21,979 CANNABINOID RESEARCH AND GREAT 6936 06:08:22,046 --> 06:08:29,487 THINGS AHEAD SO THANK YOU AGAIN. 6937 06:08:29,554 --> 06:08:30,755 >> THANK YOU SO MUCH. 6938 06:08:30,822 --> 06:08:32,990 I WOULD LIKE TO EXTENT THIS 6939 06:08:33,057 --> 06:08:36,994 THANKS OF COURSE TO OUR KEY NOTE 6940 06:08:37,061 --> 06:08:39,197 SPEAKERS AND GREAT AND 6941 06:08:39,263 --> 06:08:42,667 PROVOCATIVE TALKS AND TO NCCIH 6942 06:08:42,733 --> 06:08:44,168 OFFICE OF COMMUNICATION AND HAVE 6943 06:08:44,235 --> 06:08:46,070 OUR SCIENTIFIC WRITER TAKING 6944 06:08:46,137 --> 06:08:48,005 NOTES. 6945 06:08:48,072 --> 06:08:49,440 HOPEFULLY THERE WILL BE AN 6946 06:08:49,507 --> 06:08:50,875 EXECUTIVE SUMMARY ON THE NCCIH 6947 06:08:50,942 --> 06:08:53,077 WEB PAGE AT SOME POINT AND WE 6948 06:08:53,144 --> 06:08:55,413 HAD SO MANY REGISTRANTS FOR THIS 6949 06:08:55,480 --> 06:08:59,016 VIDEOCAST OF THE MEETING THANKS 6950 06:08:59,083 --> 06:09:02,887 TO THE FRAET WORK AND TO ALL THE 6951 06:09:02,954 --> 06:09:05,623 COLLEAGUES AND TO YOU ALL AND 6952 06:09:05,690 --> 06:09:08,392 TRAINEES AND CO-P.I.s AND 6953 06:09:08,459 --> 06:09:10,528 EVERYBODY WHO HELPS YOU WITH THE 6954 06:09:10,595 --> 06:09:12,330 IMPORTANT WORK. 6955 06:09:12,396 --> 06:09:13,798 THANK YOU SO MUCH. 6956 06:09:13,865 --> 06:09:17,068 THIS MEETING IS NOW OFFICIALLY 6957 06:09:17,134 --> 06:09:17,335 ADJOURNED. 6958 06:09:17,401 --> 06:09:21,072 AND BEFORE WE GO, THOSE WHO STAY 6959 06:09:21,138 --> 06:09:23,708 AT THE PRESIDENT HOTEL WILL HAVE 6960 06:09:23,774 --> 06:09:34,285 A SHUTTLE COMING AT 5:30 TO THE 6961 06:09:34,352 --> 06:09:36,754 GETAWAY TO BE DROPPED OFF. 6962 06:09:36,821 --> 06:09:37,889 5:30 PLEASE BE THERE FOR THE 6963 06:09:37,955 --> 06:09:41,158 PICK UP FOR YOUR HOTEL AND IT'S 6964 06:09:41,225 --> 06:09:44,061 A SHORT WALK TO BETHESDA WITH 6965 06:09:44,128 --> 06:09:45,763 LOTS OF GREAT RESTAURANTS AND 6966 06:09:45,830 --> 06:09:46,998 LITTLE CAFES. 6967 06:09:47,064 --> 06:09:51,602 SO WE ENCOURAGE YOU TO CONTINUE 6968 06:09:51,669 --> 06:09:57,341 COLLABORATING AND WORKING AND 6969 06:09:57,408 --> 06:09:59,677 EXHANG 6970 06:09:59,744 --> 06:10:04,015 EXHANGING -- EXCHANGING IDEAS 6971 06:10:04,081 --> 06:10:05,049 AND WE HOPE YOU WILL ENJOY YOUR 6972 06:10:05,116 --> 06:10:05,283 EVENING. 6973 06:10:05,349 --> 06:10:05,616 THANK YOU.