1 00:00:05,600 --> 00:00:09,280 I'D LIKE TO WELCOME YOU TO THE 2 00:00:09,280 --> 00:00:11,080 PROGRAM FOR TODAY AND BEFORE WE 3 00:00:11,080 --> 00:00:12,600 JUMP IN IT'S ALWAYS IMPORTANT WE 4 00:00:12,600 --> 00:00:15,160 GAVEL INTO THE SESSION AND SO 5 00:00:15,160 --> 00:00:19,960 I'D LIKE TO ASK THAT OUR ACTING 6 00:00:19,960 --> 00:00:21,960 DEPUTY DIRECTOR DR. SCHMITT 7 00:00:21,960 --> 00:00:24,720 GAVEL UP AND OPEN UP THE SESSION 8 00:00:24,720 --> 00:00:25,880 SO CLAIRE OVER TO YOU. 9 00:00:25,880 --> 00:00:31,760 >>HERE WE GO. 10 00:00:31,760 --> 00:00:40,080 >>WELCOME TO OUR 33rd NCATS OUR 11 00:00:40,080 --> 00:00:44,680 FIRST IN-PERSON-HYBRID AFTER 12 00:00:44,680 --> 00:00:45,720 PANDEMIC CONDITIONS. 13 00:00:45,720 --> 00:00:53,360 IT'S GREAT TO HAVE PEOPLE AND 14 00:00:53,360 --> 00:00:57,160 THE VIRTUAL TABLE AS WELL. 15 00:00:57,160 --> 00:00:58,880 THANK YOU ALL FOR JOINING TODAY. 16 00:00:58,880 --> 00:01:00,200 BEFORE WE GET INTO THE AGENDA 17 00:01:00,200 --> 00:01:01,760 AND OTHER ACTIVITIES OF THE 18 00:01:01,760 --> 00:01:05,400 AFTERNOON I WANT TO TURN IT OVER 19 00:01:05,400 --> 00:01:07,120 TO DR. ANNA RAMSEY-EWING TO GO 20 00:01:07,120 --> 00:01:11,000 OVER A FEW OF THE HOUSEKEEPING 21 00:01:11,000 --> 00:01:12,960 ITEMS AS WELL AS LOGISTICS AND 22 00:01:12,960 --> 00:01:14,920 AGENDA BEFORE WE DIVE INTO THE 23 00:01:14,920 --> 00:01:15,160 REPORTS. 24 00:01:15,160 --> 00:01:19,440 ANNA OVER TO YOU. 25 00:01:19,440 --> 00:01:21,440 >>ROLL CALL. 26 00:01:21,440 --> 00:01:27,120 MEMBERS IN ATTENDANCE ARE SURGE 27 00:01:27,120 --> 00:01:37,600 YO -- SERGIO AGUILAR-GAXIOLA. 28 00:01:42,760 --> 00:01:49,480 ROBIN MERMELSTEIN. 29 00:01:49,480 --> 00:01:54,440 AND NOT PRESENT IS MARSHALL 30 00:01:54,440 --> 00:01:54,720 SUMMAR. 31 00:01:54,720 --> 00:01:57,880 THE AGENDA TODAY FIRST OUR 32 00:01:57,880 --> 00:01:59,760 DIRECTOR WITH THE DIRECTOR'S 33 00:01:59,760 --> 00:02:00,160 REPORT. 34 00:02:00,160 --> 00:02:02,960 NEXT WE'LL HAVE A SPECIAL 35 00:02:02,960 --> 00:02:09,560 PRESENTATION OF THE 2024 NCATS 36 00:02:09,560 --> 00:02:11,560 STRATEGIC PLAN AND THEN AFTER 37 00:02:11,560 --> 00:02:13,000 THE BREAK WE'LL OUR PROGRAM 38 00:02:13,000 --> 00:02:15,080 UPDATE FROM THE DIVISION OF 39 00:02:15,080 --> 00:02:16,720 CLINICAL INNOVATION AND FINALLY 40 00:02:16,720 --> 00:02:19,400 WE'LL HAVE A PROGRAM UPDATE FROM 41 00:02:19,400 --> 00:02:24,840 THE DIVISION OF RESEARCH 42 00:02:24,840 --> 00:02:28,720 INNOVATION BY DOCTORS BROOKS AND 43 00:02:28,720 --> 00:02:30,520 TINA URV. 44 00:02:30,520 --> 00:02:31,760 BECAUSE WE'RE USING A HYBRID 45 00:02:31,760 --> 00:02:33,320 MEETING FORMAT THOSE ON SITE 46 00:02:33,320 --> 00:02:36,520 NEED TO USE THE LAPTOP AND VIDEO 47 00:02:36,520 --> 00:02:41,240 AND WITHOUT AUDIO AND THOSE 48 00:02:41,240 --> 00:02:43,680 PARTICIPATING VIRTUALLY ARE FREE 49 00:02:43,680 --> 00:02:46,040 TO SPEAK BUT WE REQUEST YOU USE 50 00:02:46,040 --> 00:02:48,280 THE RAISE HAND OR CHAT FEATURE 51 00:02:48,280 --> 00:02:50,080 AND WAIT TO BE CALLED UPON TO 52 00:02:50,080 --> 00:02:50,800 PROVIDE INPUT. 53 00:02:50,800 --> 00:02:52,720 ALL PARTICIPANTS ALLOW SPEAKERS 54 00:02:52,720 --> 00:02:54,400 TO MOVE THROUGH THEIR 55 00:02:54,400 --> 00:02:55,320 PRESENTATIONS NOTING COMMENTS 56 00:02:55,320 --> 00:02:57,040 AND/OR QUESTIONS AND PRESENT 57 00:02:57,040 --> 00:02:59,120 THEM WHEN CALLED UPON. 58 00:02:59,120 --> 00:03:01,760 MEMBERS MUST ENSURE DURING 59 00:03:01,760 --> 00:03:03,800 HYBRID MEETINGS CONFIDENTIAL 60 00:03:03,800 --> 00:03:06,720 MATTERS ARE NOT INADVERTENTLY 61 00:03:06,720 --> 00:03:08,520 OVERHEARD BY USING THE 62 00:03:08,520 --> 00:03:10,560 VOICE-ENABLED DEVICES. 63 00:03:10,560 --> 00:03:12,360 WE DO NOT ANTICIPATE WE'LL HAVE 64 00:03:12,360 --> 00:03:13,720 ANY SUCH SESSIONS DURING THE 65 00:03:13,720 --> 00:03:18,440 OPEN WE'RE USING THE VIDEOCAST 66 00:03:18,440 --> 00:03:22,040 FEATURE AS AN IT'S OPEN MEETING. 67 00:03:22,040 --> 00:03:23,040 YOU MAY MAKE COMMENTS UNTIL JUNE 68 00:03:23,040 --> 00:03:26,720 THE BY USING THE E-MAIL FUNCTION 69 00:03:26,720 --> 00:03:30,280 ON THE NIH VIDEOCAST WEBSITE 70 00:03:30,280 --> 00:03:33,520 SEND LIVE FEEDBACK BUTTON OR TO 71 00:03:33,520 --> 00:03:36,120 NCATS COUNCIL INPUT AT MAIL AT 72 00:03:36,120 --> 00:03:36,880 NIH.gov. 73 00:03:36,880 --> 00:03:39,880 MAKE SURE WHEN YOU'RE SPEAKING 74 00:03:39,880 --> 00:03:41,560 YOUR CAMERA IS ON SO YOU'RE 75 00:03:41,560 --> 00:03:43,240 SPOTLIGHTED FOR THE REVIEWERS OF 76 00:03:43,240 --> 00:03:44,360 THE VIDEOCAST. 77 00:03:44,360 --> 00:03:47,120 IF YOU'RE NOT ON CAMERA WHAT 78 00:03:47,120 --> 00:03:53,080 HAPPENS IS THE PREVIOUS SPEAKER 79 00:03:53,080 --> 00:03:54,640 REMAINS HIGHLIGHTED. 80 00:03:54,640 --> 00:04:00,640 THE FUTURE MEETINGS ARE AS 81 00:04:00,640 --> 00:04:01,800 FOLLOWS AND THE JANUARY MEETING 82 00:04:01,800 --> 00:04:03,880 IS GOING TO BE A VIRTUAL MEETING 83 00:04:03,880 --> 00:04:05,680 HELD OVER TWO DAYS MORE THAN 84 00:04:05,680 --> 00:04:06,480 LIKELY. 85 00:04:06,480 --> 00:04:08,920 WE'LL HAVE FACE TO FACE MEETINGS 86 00:04:08,920 --> 00:04:12,120 ON MAY 23 AND SEPTEMBER 26 IN 87 00:04:12,120 --> 00:04:12,320 2024. 88 00:04:12,320 --> 00:04:14,480 IN 2025 OUR JANUARY MEETING WILL 89 00:04:14,480 --> 00:04:19,760 BE HELD ON THE 30th AND 31st 90 00:04:19,760 --> 00:04:22,080 ALSO A VIRTUAL MEETING AND MAY 91 00:04:22,080 --> 00:04:24,640 22 AND SEPTEMBER 25, 2025 WE'LL 92 00:04:24,640 --> 00:04:27,760 HAVE FACE TO FACE MEETINGS. 93 00:04:27,760 --> 00:04:31,040 SO WE ARE CONSIDERING THE 94 00:04:31,040 --> 00:04:32,840 MINUTES FROM THE JANUARY 2023 95 00:04:32,840 --> 00:04:33,080 MEETING. 96 00:04:33,080 --> 00:04:35,080 DO I HAVE THE MOTION TO APPROVE 97 00:04:35,080 --> 00:04:38,400 THE MINUTES? 98 00:04:38,400 --> 00:04:40,040 >>MOVE TO APPROVE. 99 00:04:40,040 --> 00:04:40,600 >>SECOND? 100 00:04:40,600 --> 00:04:43,000 >>ALL IN FAVOR? 101 00:04:43,000 --> 00:04:44,280 ANY OPPOSED? 102 00:04:44,280 --> 00:04:45,520 ANY ABSTENTIONS? 103 00:04:45,520 --> 00:04:52,960 WITH THAT THE MINUTES ARE 104 00:04:52,960 --> 00:04:53,200 APPROVED. 105 00:04:53,200 --> 00:04:54,480 NOW WE'LL HAVE THE OPPORTUNITY 106 00:04:54,480 --> 00:04:55,960 TO ENJOY THE DIRECTOR'S REPORT 107 00:04:55,960 --> 00:04:58,280 FROM DR. JONI RUTTER. 108 00:04:58,280 --> 00:04:58,960 TAKE IT AWAY. 109 00:04:58,960 --> 00:05:01,400 >>ALL RIGHT. 110 00:05:01,400 --> 00:05:02,440 THANK YOU SO MUCH 111 00:05:02,440 --> 00:05:03,040 DR. RAMSEY-EWING. 112 00:05:03,040 --> 00:05:04,480 WE CAN GO AHEAD AND PROCEED TO 113 00:05:04,480 --> 00:05:07,680 THE NEXT SLIDE AND I'LL GO AHEAD 114 00:05:07,680 --> 00:05:09,240 AND JUMP IN. 115 00:05:09,240 --> 00:05:10,880 AT OUR LAST COUNCIL MEETING I 116 00:05:10,880 --> 00:05:12,160 ENDED MY DIRECTOR'S REPORT WITH 117 00:05:12,160 --> 00:05:14,520 TWO HIGH-LEVEL SUMMARY AND 118 00:05:14,520 --> 00:05:17,000 THOUGHT IT WOULD BE A GOOD WAY 119 00:05:17,000 --> 00:05:17,960 OF CONNECTING THESE REPORTS 120 00:05:17,960 --> 00:05:18,240 TOGETHER. 121 00:05:18,240 --> 00:05:20,360 I'M JUST SHOWING THIS HERE TO 122 00:05:20,360 --> 00:05:22,360 REMIND US WHAT WE TALKED ABOUT 123 00:05:22,360 --> 00:05:24,720 LAST TIME AND I'LL DO THE SAME 124 00:05:24,720 --> 00:05:26,920 AT THE END OF THIS MEETING TO OR 125 00:05:26,920 --> 00:05:27,800 END OF THIS REPORT. 126 00:05:27,800 --> 00:05:31,400 THE LAST TIME IT WAS MY FIRST 127 00:05:31,400 --> 00:05:34,000 MEETING AS THE DIRECTOR OF NCATS 128 00:05:34,000 --> 00:05:37,760 AND WAS DELIGHTED TO PROVIDE 129 00:05:37,760 --> 00:05:39,560 THAT PRESENTATION AT THE TIME SO 130 00:05:39,560 --> 00:05:41,080 I'M GRATEFUL TO BE HERE AGAIN 131 00:05:41,080 --> 00:05:43,520 TODAY TALKING AND WE'LL TALK A 132 00:05:43,520 --> 00:05:46,080 LITTLE BIT ABOUT SOME OF OUR 133 00:05:46,080 --> 00:05:46,840 IMPACTFUL ADVANCES AND I'LL GIVE 134 00:05:46,840 --> 00:05:48,760 SOME EXAMPLES OF THAT AND LAST 135 00:05:48,760 --> 00:05:51,200 TIME WE ALSO PRESENTED THE PLAN 136 00:05:51,200 --> 00:05:54,880 THAT WE WERE UNDERTAKING FOR OUR 137 00:05:54,880 --> 00:05:56,240 STRATEGIC PLANNING SESSIONS. 138 00:05:56,240 --> 00:06:00,720 I WILL BE DELIGHTED TO TALK TO 139 00:06:00,720 --> 00:06:02,720 YOU ABOUT THE ONGOING ACTIVITIES 140 00:06:02,720 --> 00:06:04,800 IN THAT REGARD AND WE'LL HAVE A 141 00:06:04,800 --> 00:06:06,600 SPECIAL SESSION FOR OUR COUNCIL 142 00:06:06,600 --> 00:06:07,640 TO TALK ABOUT THE STRATEGIC 143 00:06:07,640 --> 00:06:08,280 PLANNING WORK WE'RE DOING. 144 00:06:08,280 --> 00:06:10,320 I LOOK FORWARD TO TALKING ABOUT 145 00:06:10,320 --> 00:06:14,480 THOSE AND WE'LL CONTINUE TO MOVE 146 00:06:14,480 --> 00:06:14,720 ONWARD. 147 00:06:14,720 --> 00:06:16,840 WITH THAT I'LL GIVE YOU A SENSE 148 00:06:16,840 --> 00:06:18,560 OF SOME OF THE COMINGS AND 149 00:06:18,560 --> 00:06:20,920 GOINGS AROUND THE HORN AT THE 150 00:06:20,920 --> 00:06:22,120 NIH AS WELL AS NCATS. 151 00:06:22,120 --> 00:06:23,120 IN THE NEXT SLIDE I WANTED TO 152 00:06:23,120 --> 00:06:29,080 GIVE YOU A SENSE OF THE ONGOING 153 00:06:29,080 --> 00:06:30,720 OPENINGS OR SEVERAL LEADERSHIP 154 00:06:30,720 --> 00:06:32,360 POSITIONS WITHIN THE NIH AND 155 00:06:32,360 --> 00:06:33,800 SPECIFICALLY WITHIN THE 156 00:06:33,800 --> 00:06:37,200 INSTITUTES AND CENTERS AS WELL 157 00:06:37,200 --> 00:06:39,760 AS WITHIN THE OFFICE OF THE 158 00:06:39,760 --> 00:06:40,000 DIRECTOR. 159 00:06:40,000 --> 00:06:42,040 AS YOU CAN SEE THERE'S A VARIETY 160 00:06:42,040 --> 00:06:47,080 OF OPENINGS AT OUR CENTRALIZED 161 00:06:47,080 --> 00:06:50,120 I.T. SPACE WITHIN THE NIH. 162 00:06:50,120 --> 00:06:53,600 OUR FOGARTY INTERNATIONAL CENTER 163 00:06:53,600 --> 00:06:56,840 AND THE NIAID THE OPENINGS 164 00:06:56,840 --> 00:06:57,840 WITHIN THE INSTITUTES AND 165 00:06:57,840 --> 00:06:58,280 CENTER. 166 00:06:58,280 --> 00:07:00,240 WITHIN THE OFFICE OF THE 167 00:07:00,240 --> 00:07:06,840 DIRECTOR, WE HAVE OTHER OPENINGS 168 00:07:06,840 --> 00:07:08,600 AS WELL THE DIRECTORS FOR THE 169 00:07:08,600 --> 00:07:09,880 COMMON FUND PROGRAM. 170 00:07:09,880 --> 00:07:10,880 THAT'S SOMETHING WE WORK CLOSELY 171 00:07:10,880 --> 00:07:15,120 WITH SO WE'RE EXCITED TO SEE 172 00:07:15,120 --> 00:07:17,440 THIS SEARCH IS ONGOING AND AS 173 00:07:17,440 --> 00:07:18,640 WELL AS THE OFFICE OF 174 00:07:18,640 --> 00:07:20,520 LEGISLATIVE POLICY AND ANALYSIS. 175 00:07:20,520 --> 00:07:23,080 SO THESE ARE TWO OF THE HIGHER 176 00:07:23,080 --> 00:07:25,280 LEVEL OPENINGS WE HAVE AT THE 177 00:07:25,280 --> 00:07:25,440 NIH. 178 00:07:25,440 --> 00:07:28,760 OF COURSE YOU HAVE LIKELY HEARD 179 00:07:28,760 --> 00:07:30,640 THE NEWS ABOUT THE NIH DIRECTOR 180 00:07:30,640 --> 00:07:31,320 POSITION. 181 00:07:31,320 --> 00:07:33,480 SO GO TO THE NEXT SLIDE PLEASE. 182 00:07:33,480 --> 00:07:40,440 WE'D LIKE TO CONGRATULATE MONICA 183 00:07:40,440 --> 00:07:42,000 BERTOGNOLLI FOR HER NOMINATION 184 00:07:42,000 --> 00:07:43,840 AS THE NEXT NIH DIRECTOR. 185 00:07:43,840 --> 00:07:46,640 SHE CURRENTLY SERVES AS THE 186 00:07:46,640 --> 00:07:47,800 DIRECTOR OF THE NATIONAL CANCER 187 00:07:47,800 --> 00:07:48,440 INSTITUTE. 188 00:07:48,440 --> 00:07:49,760 THERE'S A BIT OF A PROCESS HERE 189 00:07:49,760 --> 00:07:52,320 THAT NEEDS TO BE TAKE PLACE 190 00:07:52,320 --> 00:07:54,400 BEFORE SHE CAN TAKE THE ROLE OF 191 00:07:54,400 --> 00:07:57,880 THE NIH DIRECTOR AND SO THIS IS 192 00:07:57,880 --> 00:07:59,320 LARGELY PENDING THOSE 193 00:07:59,320 --> 00:07:59,640 ACTIVITIES. 194 00:07:59,640 --> 00:08:02,760 HER CONFIRMATION WILL BE BY THE 195 00:08:02,760 --> 00:08:03,520 UNITED STATES SENATE AND SO 196 00:08:03,520 --> 00:08:05,440 UNTIL THOSE PROCEEDINGS CAN 197 00:08:05,440 --> 00:08:08,680 HAPPEN, DR. LARRY TABAK WILL 198 00:08:08,680 --> 00:08:10,760 CONTINUE IN HIS AS SERVING AS 199 00:08:10,760 --> 00:08:14,960 THE NIH DIRECTOR. 200 00:08:14,960 --> 00:08:18,240 THE PROCESS IS FAIRLY LENGTHY IN 201 00:08:18,240 --> 00:08:25,480 WHICH DR. BERTOGNOLI WILL MEET 202 00:08:25,480 --> 00:08:29,520 WITH MEMBERS OF THE DEPARTMENT 203 00:08:29,520 --> 00:08:32,880 AND BARRING OBJECTIONS THERE 204 00:08:32,880 --> 00:08:34,560 WILL BE A HEARING THAT GENERALLY 205 00:08:34,560 --> 00:08:37,520 OCCURS A FEW DAYS AFTER THE 206 00:08:37,520 --> 00:08:38,920 HEARING TAKES PLACE. 207 00:08:38,920 --> 00:08:43,200 THE ONCE CONFIRMED THEN DR. SHE 208 00:08:43,200 --> 00:08:47,120 CAN BEGIN THE ROLE AS THE NIH 209 00:08:47,120 --> 00:08:47,400 DIRECTOR. 210 00:08:47,400 --> 00:08:48,960 THAT'S A WHOLE PROCESS THAT 211 00:08:48,960 --> 00:08:50,640 NEEDS TO TAKE PLACE BEFORE THAT 212 00:08:50,640 --> 00:08:51,520 CAN HAPPEN. 213 00:08:51,520 --> 00:08:53,200 IT'S STILL PENDING AT THIS STAGE 214 00:08:53,200 --> 00:08:56,360 AND UNTIL OF COURSE THAT TAKES 215 00:08:56,360 --> 00:08:59,360 PLACE THE NCI DIRECTOR POSITION 216 00:08:59,360 --> 00:09:00,920 DOESN'T REQUIRE SENATE 217 00:09:00,920 --> 00:09:01,560 CONFIRMATION BUT SOMETHING WE'LL 218 00:09:01,560 --> 00:09:03,600 NEED TO FOLLOW AFTER THE PROCESS 219 00:09:03,600 --> 00:09:03,880 CONCLUDES. 220 00:09:03,880 --> 00:09:05,480 THAT'S GENERALLY THE PROCESS 221 00:09:05,480 --> 00:09:10,520 THAT WILL GO FORWARD. 222 00:09:10,520 --> 00:09:18,960 STAY TUNED FOR ALL THIS. 223 00:09:18,960 --> 00:09:20,640 LET'S TURN TO THE NCATS 224 00:09:20,640 --> 00:09:21,800 ACTIVITIES AND LEADERSHIP ROLES 225 00:09:21,800 --> 00:09:24,400 AND ACTIVE RECRUITMENTS HERE AS 226 00:09:24,400 --> 00:09:24,680 WELL. 227 00:09:24,680 --> 00:09:27,200 SINCE I WAS NOMINATED OVER THE 228 00:09:27,200 --> 00:09:30,600 LAST SIX MONTHS WE HAVE NOW BEEN 229 00:09:30,600 --> 00:09:33,240 ABLE TO MOVE FORWARD SOME OTHER 230 00:09:33,240 --> 00:09:34,640 ACTING POSITIONS THAT HAVE BEEN 231 00:09:34,640 --> 00:09:37,200 OPEN FOR A WHILE OR HAVE BEEN 232 00:09:37,200 --> 00:09:38,880 ENCUMBERED FOR A WHILE BY GROUPS 233 00:09:38,880 --> 00:09:41,160 OR PEOPLE ACTING IN THESE 234 00:09:41,160 --> 00:09:42,520 POSITIONS SHOWN IN RED. 235 00:09:42,520 --> 00:09:43,920 WE HAVE A VARIETY WE'RE NOW 236 00:09:43,920 --> 00:09:46,760 CONTINUING TO MOVE FORWARD IN 237 00:09:46,760 --> 00:09:48,560 ACTIVE SEARCHS AND THERE'S 238 00:09:48,560 --> 00:09:49,760 VARIOUS STAGES OF THIS PROCESS 239 00:09:49,760 --> 00:09:52,640 BUT WE'RE EXCITED TO GET THOSE 240 00:09:52,640 --> 00:09:54,760 MOVING AND TO HAVE A STABLE 241 00:09:54,760 --> 00:09:57,640 CADRE OF PEOPLE WHO ARE IN THESE 242 00:09:57,640 --> 00:10:00,440 LEADERSHIP POSITIONS AS WE MOVE 243 00:10:00,440 --> 00:10:00,680 FORWARD. 244 00:10:00,680 --> 00:10:03,520 SO THIS IS I HOPE A REALLY 245 00:10:03,520 --> 00:10:05,760 INTERIM STATE WE'RE IN NOW AND I 246 00:10:05,760 --> 00:10:07,520 EXPECT WE'LL BE ABLE TO GIVE YOU 247 00:10:07,520 --> 00:10:08,920 MORE INFORMATION AT THE NEXT 248 00:10:08,920 --> 00:10:09,840 COUNCIL MEETING AS TO OUR 249 00:10:09,840 --> 00:10:20,200 PROGRESS IN THIS AREA. 250 00:10:21,000 --> 00:10:23,920 AND WE HAVE A NEW DEPUTY 251 00:10:23,920 --> 00:10:27,080 DIRECTOR IN THE OFFICE OF 252 00:10:27,080 --> 00:10:32,400 SPECIAL INITIATIVES. 253 00:10:32,400 --> 00:10:35,120 GEETHAT COMES TO US FROM THE 254 00:10:35,120 --> 00:10:37,040 NATIONAL INSTITUTE OF HEALTH AND 255 00:10:37,040 --> 00:10:39,720 FROM THE OFFICE OF GENOMICS 256 00:10:39,720 --> 00:10:40,240 COORDINATION AND PROGRAM 257 00:10:40,240 --> 00:10:41,920 DIRECTOR IN THE DIVISION OF 258 00:10:41,920 --> 00:10:42,480 TRANSLATIONAL RESEARCH. 259 00:10:42,480 --> 00:10:46,480 SHE'S ALSO SPENT TIME IN THE 260 00:10:46,480 --> 00:10:48,000 PORTFOLIO ANALYSIS AND POLICY 261 00:10:48,000 --> 00:10:49,760 ANALYST IN THE OFFICE OF 262 00:10:49,760 --> 00:10:51,480 PORTFOLIO ANALYSIS IN THE 263 00:10:51,480 --> 00:10:52,960 DIVISION OF PROGRAM 264 00:10:52,960 --> 00:10:53,520 COORDINATION, PLANNING AND 265 00:10:53,520 --> 00:10:57,000 STRATEGY INITIATIVES. 266 00:10:57,000 --> 00:11:01,040 THAT'S THE DPCPSI PROGRAM I 267 00:11:01,040 --> 00:11:03,040 MENTIONED EARLIER AND PRIOR SHE 268 00:11:03,040 --> 00:11:05,560 WORKED AS A REGULATORY PROJECT 269 00:11:05,560 --> 00:11:08,440 MANAGER IN THE OFFICE OF BIO 270 00:11:08,440 --> 00:11:09,760 STATISTICS AND EPIDEMIOLOGY AND 271 00:11:09,760 --> 00:11:12,040 THE CENTER OF BIOLOGIC RESEARCH. 272 00:11:12,040 --> 00:11:14,440 AND I'VE HAD THE PLEASURE OF 273 00:11:14,440 --> 00:11:16,880 WORKING WITH THE OFFICE OF DATA 274 00:11:16,880 --> 00:11:23,440 SCIENCE AND STRATEGIES DR. SUSAN 275 00:11:23,440 --> 00:11:28,160 GREGURICK AND GEETHA IS THE ONE 276 00:11:28,160 --> 00:11:32,360 WHO HONES THE PROCESS AND IS THE 277 00:11:32,360 --> 00:11:33,680 PROGRAMMATIC LEAD AND WORKS 278 00:11:33,680 --> 00:11:35,600 ACROSS HHS ON THE PROCESS AND 279 00:11:35,600 --> 00:11:38,560 GREAT TO HAVE HER WITHIN NCATS 280 00:11:38,560 --> 00:11:40,000 AND WOULD LIKE TO WELCOME HER TO 281 00:11:40,000 --> 00:11:40,400 THE FOLD. 282 00:11:40,400 --> 00:11:47,080 THE NEXT SLIDE I WANTED TO 283 00:11:47,080 --> 00:11:51,040 HIGHLIGHT A RETIREMENT. 284 00:11:51,040 --> 00:11:53,880 SAM BOZZETTE WAS OUR CHIEF 285 00:11:53,880 --> 00:11:55,600 MEDICAL OFFICER AND HAD 286 00:11:55,600 --> 00:11:56,960 EXPERTISE IN INFECTIOUS 287 00:11:56,960 --> 00:11:57,360 DISEASES. 288 00:11:57,360 --> 00:11:59,400 HE'S HAD A GREAT DEAL THAT 289 00:11:59,400 --> 00:12:01,800 AFFECTED A GREAT DEAL OF HIV 290 00:12:01,800 --> 00:12:04,760 POLICY AND OTHER INFECTIOUS 291 00:12:04,760 --> 00:12:05,920 DISEASES POLICIES AND ECONOMICS 292 00:12:05,920 --> 00:12:08,520 AND HAS DONE WORK IN CLINICAL 293 00:12:08,520 --> 00:12:11,080 TRIALS AND HELPED US STAND UP 294 00:12:11,080 --> 00:12:14,120 OUR OFFICE OF TRANSLATIONAL 295 00:12:14,120 --> 00:12:15,360 MEDICINE AND THIS HAPPENED RIGHT 296 00:12:15,360 --> 00:12:17,240 WHEN THE PANDEMIC HIT BUT AT THE 297 00:12:17,240 --> 00:12:19,800 SAME TIME HIS INFECTIOUS DISEASE 298 00:12:19,800 --> 00:12:22,280 EXPERTISE WAS REALLY INVALUABLE 299 00:12:22,280 --> 00:12:23,080 DURING THAT TIME AND 300 00:12:23,080 --> 00:12:25,640 PARTICULARLY WORKED WITH THE 301 00:12:25,640 --> 00:12:28,080 ACTIVE PROGRAM PRIMARILY ACTIVE 302 00:12:28,080 --> 00:12:32,800 1 ON THE IMMUNOMODULATORS AND 303 00:12:32,800 --> 00:12:35,360 THE NEWER EFFORT CALLED STRIVE 304 00:12:35,360 --> 00:12:39,600 LIKE THE STRATEGIES FOR TREATING 305 00:12:39,600 --> 00:12:42,280 COVID-19 AND ALSO PLAYED A 306 00:12:42,280 --> 00:12:44,080 CRITICAL ROLE IN THE NATIONAL 307 00:12:44,080 --> 00:12:46,600 COVID COHORT COLLABORATIVE DATA 308 00:12:46,600 --> 00:12:47,440 ACCESS PROCESSES AS WELL. 309 00:12:47,440 --> 00:12:48,720 HE RETIRED LAST MONTH AND WE'RE 310 00:12:48,720 --> 00:12:50,240 WORK ON REPLACING HIM IN THE 311 00:12:50,240 --> 00:12:50,800 COMING MONTHS. 312 00:12:50,800 --> 00:12:54,520 AND THEN ON THE NEXT SLIDE ONE 313 00:12:54,520 --> 00:12:55,760 LAST RETIREMENT I WANTED TO 314 00:12:55,760 --> 00:12:57,840 RELAY TO THIS GROUP BECAUSE THIS 315 00:12:57,840 --> 00:13:02,920 IS A SPECIAL ONE. 316 00:13:02,920 --> 00:13:05,600 AS ANTONETTE NEAL HAS BEEN PART 317 00:13:05,600 --> 00:13:07,120 OF OUR COUNCIL AND MANAGEMENT 318 00:13:07,120 --> 00:13:10,160 TEAM AT NCATS WORKING WITH 319 00:13:10,160 --> 00:13:11,880 DR. RAMSEY-EWING IN THE OFFICE 320 00:13:11,880 --> 00:13:13,080 OF THE DIRECTOR OF EXTRAMURAL 321 00:13:13,080 --> 00:13:13,360 ACTIVITIES. 322 00:13:13,360 --> 00:13:14,800 SHE'S BEEN IN THE GOVERNMENT FOR 323 00:13:14,800 --> 00:13:17,720 OVER 30 YEARS AND HAS BEEN WITH 324 00:13:17,720 --> 00:13:20,760 NCATS FROM THE INCEPTION AND HAS 325 00:13:20,760 --> 00:13:23,000 BEEN A KEY MEMBER OF OUR COUNCIL 326 00:13:23,000 --> 00:13:25,160 TEAM AND HAS BEEN BEHIND THE 327 00:13:25,160 --> 00:13:27,680 SCENES AND I JUST WANTED TO 328 00:13:27,680 --> 00:13:29,600 RECOGNIZE HER IN HER RETIREMENT 329 00:13:29,600 --> 00:13:31,480 AND WISH HER WELL. 330 00:13:31,480 --> 00:13:33,040 SHE'S GOING TO BE MISSED. 331 00:13:33,040 --> 00:13:34,040 THANK YOU. 332 00:13:34,040 --> 00:13:38,000 LET'S MOVE ON TO THE NEXT SLIDE. 333 00:13:38,000 --> 00:13:41,280 I HAVE A FEW NEWS AND 334 00:13:41,280 --> 00:13:42,280 ANNOUNCEMENTS AND STARTING WITH 335 00:13:42,280 --> 00:13:43,320 AN OVERVIEW OF THE BUDGET. 336 00:13:43,320 --> 00:13:45,360 TO THE NEXT SLIDE, PLEASE. 337 00:13:45,360 --> 00:13:47,120 THIS IS THE GRAPHICAL 338 00:13:47,120 --> 00:13:49,200 REPRESENTATION OF OUR BUDGET AT 339 00:13:49,200 --> 00:13:50,520 A GLANCE SO TO PEEK. 340 00:13:50,520 --> 00:13:55,080 THE CTSA PROGRAM IS SHOWN MORE 341 00:13:55,080 --> 00:13:58,160 IN THE TEAL COLOR AND THE CTSA 342 00:13:58,160 --> 00:14:00,960 FUNDS THE NATIONWIDE NETWORK OF 343 00:14:00,960 --> 00:14:06,680 RESEARCH INSTITUTIONS WITH 344 00:14:06,680 --> 00:14:07,240 CONSORTIUM RESOURCES AND 345 00:14:07,240 --> 00:14:09,960 COLLABORATIVES AND ALL OTHER 346 00:14:09,960 --> 00:14:11,120 ACTIVITIES SHOWN IN PURPLE. 347 00:14:11,120 --> 00:14:13,720 THIS MAKES UP A THIRD OF WHAT WE 348 00:14:13,720 --> 00:14:15,960 DO AND IT SUPPORTS THE 349 00:14:15,960 --> 00:14:17,400 INTRAMURAL AND EXTRAMURAL 350 00:14:17,400 --> 00:14:19,760 PROGRAMS INCLUDING DRUG 351 00:14:19,760 --> 00:14:20,960 REPURPOSING, TISSUE CHIPS, 352 00:14:20,960 --> 00:14:22,520 DIAGNOSTICS, ETHICS, TRAINING 353 00:14:22,520 --> 00:14:24,360 AND THE SMALL BUSINESS WORK WE 354 00:14:24,360 --> 00:14:27,160 DO AND ALSO HOUSES THE CURES 355 00:14:27,160 --> 00:14:29,240 ACCELERATION NETWORK THAT 356 00:14:29,240 --> 00:14:30,640 STIMULATE THE TRANSFORMATIVE 357 00:14:30,640 --> 00:14:31,800 EFFORTS AND PLATFORM APPROACHES 358 00:14:31,800 --> 00:14:33,560 ESPECIALLY IN THE AREAS OF UNMET 359 00:14:33,560 --> 00:14:37,000 NEEDS AND ENABLING THE PATIENT 360 00:14:37,000 --> 00:14:40,160 CENTRIC INNOVATIONS FOR STUDYING 361 00:14:40,160 --> 00:14:43,320 AND TREATING THE RARE DISEASES 362 00:14:43,320 --> 00:14:44,680 AND UNDIAGNOSED RARE DISEASES. 363 00:14:44,680 --> 00:14:47,000 I WANTED TO GIVE YOU A SENSE OF 364 00:14:47,000 --> 00:14:48,920 WHAT THAT LOOKS LIKE AND OF 365 00:14:48,920 --> 00:14:52,240 COURSE THE BUDGET PROCESS 366 00:14:52,240 --> 00:14:53,600 GENERALLY STARTS IN FEBRUARY 367 00:14:53,600 --> 00:14:55,040 WITH THE RELEASE OF THE 368 00:14:55,040 --> 00:14:56,200 PRESIDENT'S BUDGET AND THAT 369 00:14:56,200 --> 00:14:57,800 HAPPENED EARLIER THIS YEAR. 370 00:14:57,800 --> 00:15:00,360 AND IT STARTS TO GET INTO THE 371 00:15:00,360 --> 00:15:04,040 SWING OF THINGS AROUND THIS TIME 372 00:15:04,040 --> 00:15:07,000 STARTING GENERALLY IN JUNE. 373 00:15:07,000 --> 00:15:10,000 I DON'T HAVE A LOT OF NEWS TO 374 00:15:10,000 --> 00:15:11,760 REPORT TODAY BUT AFTER THE 375 00:15:11,760 --> 00:15:13,040 PRESIDENT'S BUDGET WAS RELEASED 376 00:15:13,040 --> 00:15:15,040 EARLIER THIS YEAR THERE'S A 377 00:15:15,040 --> 00:15:16,200 PROJECTION OF A FLAT BUDGET AND 378 00:15:16,200 --> 00:15:17,400 OF COURSE THAT'S JUST OF THE 379 00:15:17,400 --> 00:15:18,600 BEGINNING OF THE CONVERSATION. 380 00:15:18,600 --> 00:15:20,440 WE'LL WAIT TO SEE HOW THIS GOES 381 00:15:20,440 --> 00:15:22,080 FOR THE REMAINDER OF THE YEAR SO 382 00:15:22,080 --> 00:15:23,760 STAY TUNED AND I HAVE SOME 383 00:15:23,760 --> 00:15:26,720 UPDATES TO GIVE YOU AT OUR NEXT 384 00:15:26,720 --> 00:15:27,600 COUNCIL MEETING. 385 00:15:27,600 --> 00:15:28,640 GOING TO THE NEXT SLIDE. 386 00:15:28,640 --> 00:15:29,800 I WANTED TO GIVE YOU A SENSE OF 387 00:15:29,800 --> 00:15:31,160 WHAT WE'VE BEEN DOING SINCE WE 388 00:15:31,160 --> 00:15:32,400 LAST MET AND THERE'S BEEN A 389 00:15:32,400 --> 00:15:35,960 NUMBER OF ACTIVITIES THAT ALL 390 00:15:35,960 --> 00:15:37,760 RELY DESPITE BEING ON THE HEELS 391 00:15:37,760 --> 00:15:39,200 OF THE PANDEMIC THERE'S NO REST 392 00:15:39,200 --> 00:15:41,800 FOR THE WARY. 393 00:15:41,800 --> 00:15:43,480 WE'RE JUST AS BUSY AS EVER. 394 00:15:43,480 --> 00:15:46,000 ONE OF OUR BIGGER ANNUAL 395 00:15:46,000 --> 00:15:49,800 MEETINGS WE HOST ALONG THE WAY 396 00:15:49,800 --> 00:15:51,960 AS YOU MAY KNOW IS THE RARE 397 00:15:51,960 --> 00:15:53,720 DISEASE DAY AT THE NIH AND DO 398 00:15:53,720 --> 00:15:55,520 THIS WITH OUR PARTNERS AT THE 399 00:15:55,520 --> 00:15:57,280 CLINICAL CENTER AS WELL AND THIS 400 00:15:57,280 --> 00:15:59,440 YEAR WE HELD IT IN PERSON ALONG 401 00:15:59,440 --> 00:16:01,360 WITH A VIRTUAL OPTION. 402 00:16:01,360 --> 00:16:05,000 AND THE VIRTUAL OPTION WAS A 403 00:16:05,000 --> 00:16:05,600 RESOUNDING SUCCESS AND THREE 404 00:16:05,600 --> 00:16:07,160 TIMES MORE PEOPLE WERE ABLE TO 405 00:16:07,160 --> 00:16:09,000 JOIN VIRTUALLY AND HAD A ROBUST 406 00:16:09,000 --> 00:16:11,240 TURNOUT IN PERSON. 407 00:16:11,240 --> 00:16:13,040 WE HAD A FULL HOUSE IN PERSON 408 00:16:13,040 --> 00:16:13,240 TOO. 409 00:16:13,240 --> 00:16:16,040 AND THIS IS REALLY A FANTASTIC 410 00:16:16,040 --> 00:16:17,680 OPPORTUNITY FOR PEOPLE WHO ARE 411 00:16:17,680 --> 00:16:19,400 NOT ABLE TO TRAVEL BUT REALLY 412 00:16:19,400 --> 00:16:22,320 FEEL A PART OF THIS MEETING AND 413 00:16:22,320 --> 00:16:24,000 GIVEN THE SCOPE AND SCALE IT'S 414 00:16:24,000 --> 00:16:25,280 AN INCREDIBLY LARGE UNDERTAKING 415 00:16:25,280 --> 00:16:29,920 FOR US TO DO TO NAVIGATE ALL THE 416 00:16:29,920 --> 00:16:31,520 POSTERS, THE SPEAKING SESSIONS 417 00:16:31,520 --> 00:16:34,680 AND THE PANEL SESSIONS WITH 418 00:16:34,680 --> 00:16:35,920 PATIENTS, WITH ADVOCACY GROUPS, 419 00:16:35,920 --> 00:16:38,520 WITH THE ACADEMIC RESEARCHERS 420 00:16:38,520 --> 00:16:39,680 AND INDUSTRY. 421 00:16:39,680 --> 00:16:41,680 THIS IS REALLY ALL-COMERS TO 422 00:16:41,680 --> 00:16:43,800 TALK ABOUT WHAT WE'RE DOING IN 423 00:16:43,800 --> 00:16:44,800 RARE DISEASE DAY. 424 00:16:44,800 --> 00:16:50,960 THIS IS A HIGHLY COORDINATED 425 00:16:50,960 --> 00:16:53,080 EFFORT WHO THOSE WHO DESERVE A 426 00:16:53,080 --> 00:16:55,080 LOT OF CREDIT FOR THE SUCCESS OF 427 00:16:55,080 --> 00:16:56,240 THIS MEETING. 428 00:16:56,240 --> 00:16:57,960 GOING TO THE NEXT SLIDE AND I'LL 429 00:16:57,960 --> 00:17:00,760 GIVE YOU PICTURES OF SOME OF THE 430 00:17:00,760 --> 00:17:02,320 PANELS THAT WERE TRANSPIRING 431 00:17:02,320 --> 00:17:05,080 DURING THIS DAY. 432 00:17:05,080 --> 00:17:10,000 WE HAD SPECIAL GUESTS BRIAN 433 00:17:10,000 --> 00:17:13,240 WALLACH AND OTHERS WHO JOINED US 434 00:17:13,240 --> 00:17:18,320 AND THE PATIENT ADVOCATES AND 435 00:17:18,320 --> 00:17:19,400 PATIENTS WERE ABLE TO SHARE MUCH 436 00:17:19,400 --> 00:17:23,080 OF THEIR STORY WITH DRUG 437 00:17:23,080 --> 00:17:25,600 DEVELOPMENT FOR ALS AND WERE 438 00:17:25,600 --> 00:17:27,360 ABLE TO HEAR OTHER STORIES FROM 439 00:17:27,360 --> 00:17:29,360 PEOPLE WITH RARE DISEASES AND 440 00:17:29,360 --> 00:17:30,800 TEACHERS TRAINING THE NEXT 441 00:17:30,800 --> 00:17:33,320 GENERATION OF SCIENTISTS AND 442 00:17:33,320 --> 00:17:34,720 PATIENT ADVOCATES AND HEARING 443 00:17:34,720 --> 00:17:37,160 HOW THEY DEVELOPED 444 00:17:37,160 --> 00:17:40,080 COLLABORATIONS WITH SCIENTISTS 445 00:17:40,080 --> 00:17:42,760 AND INDUSTRY AND AT THE END IT 446 00:17:42,760 --> 00:17:45,200 WAS CAPPED OFF WITH INIMPROMPTU 447 00:17:45,200 --> 00:17:49,800 ANNOUNCEMENT OF A DRUG APPROVAL 448 00:17:49,800 --> 00:17:55,840 TO TREAT FREDERICK'S ATAXIA AND 449 00:17:55,840 --> 00:17:57,840 THE DATE FOR THIS PARTICULAR 450 00:17:57,840 --> 00:17:59,480 RARE DISEASE WAS ON RARE DISEASE 451 00:17:59,480 --> 00:18:01,120 DAY AND SURE ENOUGH THEY HEARD 452 00:18:01,120 --> 00:18:03,160 THE NEWS AT THE VERY END OF THE 453 00:18:03,160 --> 00:18:05,720 MEETING AND WERE ABLE TO MAKE AN 454 00:18:05,720 --> 00:18:06,080 ANNOUNCEMENT. 455 00:18:06,080 --> 00:18:08,360 THAT WAS QUITE A STORY BOOK 456 00:18:08,360 --> 00:18:09,520 ENDING FOR A WONDERFUL DAY. 457 00:18:09,520 --> 00:18:11,320 THIS MEETING HAS IT ALL AND I 458 00:18:11,320 --> 00:18:13,360 HOPE YOU CAN HOLD THE END OF 459 00:18:13,360 --> 00:18:16,360 FEBRUARY OF NEXT YEAR FOR RARE 460 00:18:16,360 --> 00:18:17,760 DISEASE DAY AT NIH IN 2024. 461 00:18:17,760 --> 00:18:21,960 LET'S GO TO THE NEXT SLIDE. 462 00:18:21,960 --> 00:18:24,120 WE ALSO HAD THE ASSOCIATION FOR 463 00:18:24,120 --> 00:18:25,360 CLINICAL AND TRANSLATIONAL 464 00:18:25,360 --> 00:18:27,080 SCIENCE MEETING IN PERSON THAT 465 00:18:27,080 --> 00:18:29,240 MET IN D.C. AND THIS ALSO HAD A 466 00:18:29,240 --> 00:18:31,600 ROBUST TURNOUT AND SOME OF THE 467 00:18:31,600 --> 00:18:32,880 HIGHLIGHTS WERE SHOWN HERE ON 468 00:18:32,880 --> 00:18:34,720 THE LOWER LEFT WE HAD A P.I. 469 00:18:34,720 --> 00:18:35,000 MEETING. 470 00:18:35,000 --> 00:18:37,360 YOU CAN'T TELL THERE WERE OVER 471 00:18:37,360 --> 00:18:42,160 60 P.I.s IN THE ROOM BECAUSE 472 00:18:42,160 --> 00:18:45,400 IT'S FOCUSSED ON THESE PEOPLE 473 00:18:45,400 --> 00:18:47,080 BUT HAD A WONDERFUL DISCUSSION 474 00:18:47,080 --> 00:18:48,600 WITH THE P.I.s PART OF THE 475 00:18:48,600 --> 00:18:51,080 DISCUSSION AND HAT A TOWN HALL 476 00:18:51,080 --> 00:18:52,920 FORMAT TO EXCHANGE IDEAS AND 477 00:18:52,920 --> 00:18:54,400 TALK ABOUT CURRENT ISSUES 478 00:18:54,400 --> 00:18:56,760 RELATED TO A VARIETY OF 479 00:18:56,760 --> 00:18:58,640 ACTIVITIES IN CLINICAL TRIALS 480 00:18:58,640 --> 00:19:00,800 AND COLLABORATIONS AND CLINICAL 481 00:19:00,800 --> 00:19:03,080 DATA AND REAL-WORLD DATA AND HOW 482 00:19:03,080 --> 00:19:05,960 IT CAN ENGAGE AND CAPITALIZE ON 483 00:19:05,960 --> 00:19:06,600 THESE SORTS OF OPPORTUNITIES 484 00:19:06,600 --> 00:19:07,480 MOVING FORWARD. 485 00:19:07,480 --> 00:19:08,960 I THINK THIS IS GOING TO BE 486 00:19:08,960 --> 00:19:10,000 SOMETHING THAT WILL STAY AROUND. 487 00:19:10,000 --> 00:19:13,720 BUT IN ADDITION TO THAT THERE 488 00:19:13,720 --> 00:19:15,680 WAS A LOT OF BUZZ AT THE MEETING 489 00:19:15,680 --> 00:19:17,520 AND WAS GLAD TO SEE THE 490 00:19:17,520 --> 00:19:19,560 DIVERSITY AND TRAINEES AND ALL 491 00:19:19,560 --> 00:19:21,800 THE P.I.s COMING TOGETHER TO 492 00:19:21,800 --> 00:19:22,720 TALK ABOUT WHAT WE'RE DOING IN 493 00:19:22,720 --> 00:19:28,280 THE CTSA PROGRAM. 494 00:19:28,280 --> 00:19:30,640 AND WE'VE TALKED QUITE A BIT 495 00:19:30,640 --> 00:19:32,520 ABOUT HOW ARPA-H IS THE NEW KID 496 00:19:32,520 --> 00:19:34,880 ON THE BLOCK SO TO SPEAK. 497 00:19:34,880 --> 00:19:37,000 THEY JOINED THE HHS FOLD 498 00:19:37,000 --> 00:19:40,680 RECENTLY AND WE'VE BEEN ENGAGING 499 00:19:40,680 --> 00:19:42,320 WIN ARPA-H FROM THE BEGINNING. 500 00:19:42,320 --> 00:19:43,600 THEY'RE STILL GROWING BUT WE 501 00:19:43,600 --> 00:19:46,960 JUMPED AT THE CHANCE TO BRING 502 00:19:46,960 --> 00:19:49,800 THE SMALL NEXUS OF THE EARLY 503 00:19:49,800 --> 00:19:51,480 ARPA-H LEADERSHIP TEAM TOGETHER 504 00:19:51,480 --> 00:19:56,600 TO THE NCATS LABS TO DO A TOUR. 505 00:19:56,600 --> 00:19:58,320 IT TURNED OUT ARPA-H IS A GROUP 506 00:19:58,320 --> 00:20:00,320 THAT WILL NOT HAVE AN INTRAMURAL 507 00:20:00,320 --> 00:20:00,680 PROGRAM. 508 00:20:00,680 --> 00:20:01,520 THEY WON'T HAVE LABS ASSOCIATED 509 00:20:01,520 --> 00:20:02,120 WITH THEM. 510 00:20:02,120 --> 00:20:04,040 SO WE WANTED TO GIVE THEM A 511 00:20:04,040 --> 00:20:06,920 SENSE OF OUR CAPABILITIES AND 512 00:20:06,920 --> 00:20:07,640 TRANSLATIONAL SCIENCE WORK WE 513 00:20:07,640 --> 00:20:08,640 DO. 514 00:20:08,640 --> 00:20:11,640 AND I WANTED TO TAKE A MOMENT TO 515 00:20:11,640 --> 00:20:15,160 MENTION DAN TAGLY IN THE ROOM 516 00:20:15,160 --> 00:20:20,480 TODAY IS OUR DIVISION OR OFFICE 517 00:20:20,480 --> 00:20:21,720 OF SPECIAL INITIATIVES DIRECTOR 518 00:20:21,720 --> 00:20:24,480 AND HE'S OUR CENTRAL POINT OF 519 00:20:24,480 --> 00:20:26,120 CONTACT FOR NCATS AND ALL 520 00:20:26,120 --> 00:20:29,360 INTERACTIONS WITH ARPA-H. 521 00:20:29,360 --> 00:20:36,000 WE HAVE THIS DESIGNATED PAINT OF 522 00:20:36,000 --> 00:20:37,680 CONTACT TO ENGAGE IN IDEAS AND 523 00:20:37,680 --> 00:20:38,400 CONVERSATIONS. 524 00:20:38,400 --> 00:20:39,800 I SPECT THERE'LL BE GOOD 525 00:20:39,800 --> 00:20:41,040 OPPORTUNITIES THERE AND WE'LL BE 526 00:20:41,040 --> 00:20:42,960 ABLE TO RELY THOSE TO YOU IN THE 527 00:20:42,960 --> 00:20:45,680 FUTURE AS THEY START TO UNFOLD. 528 00:20:45,680 --> 00:20:48,040 ARPA-H IS STARTING TO FIND THEIR 529 00:20:48,040 --> 00:20:49,480 SEA LEGS AND HAVE SOME 530 00:20:49,480 --> 00:20:54,840 ACTIVITIES THEY'RE ANNOUNCING 531 00:20:54,840 --> 00:20:57,360 GET UNDERWAY. 532 00:20:57,360 --> 00:20:58,200 WE'LL TALK MORE WHAT 533 00:20:58,200 --> 00:20:59,320 COLLABORATIONS AND PARTNERSHIPS 534 00:20:59,320 --> 00:21:09,600 WE CAN CONVENE. 535 00:21:37,920 --> 00:21:38,160 [DISTORTION] 536 00:21:38,160 --> 00:21:40,920 >>THIS WAS THE LAST LAUNCH ME 537 00:21:40,920 --> 00:21:45,040 OF PROGRAM MARCH 14 AND 538 00:21:45,040 --> 00:21:48,640 SEPTEMBER 2 TISSUE CHIPS UP AND 539 00:21:48,640 --> 00:21:52,320 THEY WERE RELATED TO CARDIAC 540 00:21:52,320 --> 00:21:55,640 ORGANOIDS AND THEY'RE ALREADY 541 00:21:55,640 --> 00:21:56,920 BACK ON EARTH AND BEING 542 00:21:56,920 --> 00:21:58,760 EVALUATED AS WE SPEAK. 543 00:21:58,760 --> 00:22:00,680 THIS IS THE QUITE THE MOMENT TO 544 00:22:00,680 --> 00:22:03,680 BE THERE IN PERSON AND TALK WITH 545 00:22:03,680 --> 00:22:04,840 SCIENTISTS AND RESEARCHERS 546 00:22:04,840 --> 00:22:06,560 SENDING THEM UP TO SPACE AND I 547 00:22:06,560 --> 00:22:07,920 LOOK FORWARD TO HEARING MORE AND 548 00:22:07,920 --> 00:22:10,000 TELLING YOU MORE ABOUT PERHAPS 549 00:22:10,000 --> 00:22:11,360 WHAT MIGHT BE NEXT FOR THIS. 550 00:22:11,360 --> 00:22:13,440 BUT MAYBE WE MIGHT HAVE AN 551 00:22:13,440 --> 00:22:16,120 OPPORTUNITY IN SOME WAY TO 552 00:22:16,120 --> 00:22:17,720 PERHAPS CONTINUE THIS WORK AND 553 00:22:17,720 --> 00:22:23,160 IT MAY GO TO THE MOON WHO KNOWS 554 00:22:23,160 --> 00:22:29,120 MAYBE MARS. 555 00:22:29,120 --> 00:22:32,240 I LOOK FORWARD TO RELAYING THE 556 00:22:32,240 --> 00:22:33,120 WORK WHEN WE KNOW MORE. 557 00:22:33,120 --> 00:22:35,080 IN ADDITION TO THAT LAUNCH THERE 558 00:22:35,080 --> 00:22:38,680 WAS ALSO ANOTHER LAUNCH I WANTED 559 00:22:38,680 --> 00:22:41,560 TO MENTION JUST AS EXCITING. 560 00:22:41,560 --> 00:22:44,480 THE NCATS ALLIANCE WAS LAUNCHED 561 00:22:44,480 --> 00:22:48,440 ON MARCH 15 THE DAY AFTER THE 562 00:22:48,440 --> 00:22:50,200 LAUNCH AND THE ALLIANCE IS AN 563 00:22:50,200 --> 00:22:52,720 ORGANIZATION THAT WORKS 564 00:22:52,720 --> 00:22:53,480 INDEPENDENTLY FROM NCATS. 565 00:22:53,480 --> 00:22:55,120 IT'S REALLY THERE TO RAISE 566 00:22:55,120 --> 00:22:57,280 AWARENESS ABOUT OUR EFFORTS THAT 567 00:22:57,280 --> 00:22:59,880 WE'RE DOING, HELP ADVOCATE FOR 568 00:22:59,880 --> 00:23:01,800 SOME OF THE WORK IN 569 00:23:01,800 --> 00:23:04,480 TRANSLATIONAL SCIENCE AND OFFER 570 00:23:04,480 --> 00:23:09,640 WAYS TO IMPROVE HEALTH AND THE 571 00:23:09,640 --> 00:23:12,160 QR CODE IS SHOWN HERE AND 572 00:23:12,160 --> 00:23:13,240 EXCITED TO SEE THE NUMBER OF 573 00:23:13,240 --> 00:23:15,680 GROUPS THAT ARE ENGAGED WITH THE 574 00:23:15,680 --> 00:23:16,320 NCATS ALLIANCE AND THEY'RE ALL 575 00:23:16,320 --> 00:23:22,320 LISTED HERE. 576 00:23:22,320 --> 00:23:22,840 . 577 00:23:22,840 --> 00:23:25,240 RACHEL HEADS THE ALLIANCE AND 578 00:23:25,240 --> 00:23:26,840 HAS EXPERIENCE IN POLICY AND 579 00:23:26,840 --> 00:23:29,000 LEGISLATIVE ACTIVITIES IN BIO 580 00:23:29,000 --> 00:23:32,120 SCIENCES AND IN REGULATORY 581 00:23:32,120 --> 00:23:33,280 PROCESSES ACROSS ALL STAGES AND 582 00:23:33,280 --> 00:23:43,800 THE LIFE CYCLE OF THE PRODUCTS. 583 00:23:44,360 --> 00:23:46,280 WITH THE CO-CHAIR THEY ORGANIZED 584 00:23:46,280 --> 00:23:48,600 THE GROUP TO ADVANCE THE 585 00:23:48,600 --> 00:23:49,840 TRANSLATIONAL SCIENCE ACTIVITIES 586 00:23:49,840 --> 00:23:51,680 THAT WILL HELP BRING TREATMENTS 587 00:23:51,680 --> 00:23:52,600 TO PEOPLE FASTER. 588 00:23:52,600 --> 00:23:53,720 THIS KIND OF AN ORGANIZATION 589 00:23:53,720 --> 00:23:57,560 THAT IS INDEPENDENT OF US YET 590 00:23:57,560 --> 00:23:59,240 CAN WORK WITH US ON KEY MESSAGES 591 00:23:59,240 --> 00:24:03,240 AND GELLING THESE IDEAS ACROSS 592 00:24:03,240 --> 00:24:04,440 LEADERS AND TRANSLATIONAL 593 00:24:04,440 --> 00:24:06,920 SCIENCE WILL BE CRITICAL FOR US 594 00:24:06,920 --> 00:24:07,880 AND OUR CONSENSUS AND I'M 595 00:24:07,880 --> 00:24:10,200 THRILLED TO SEE THE INTEREST AND 596 00:24:10,200 --> 00:24:11,520 ENTHUSIASM FOR THE NCATS 597 00:24:11,520 --> 00:24:11,800 ALLIANCE. 598 00:24:11,800 --> 00:24:13,840 SO IF YOU GO TO THE NEXT SLIDE 599 00:24:13,840 --> 00:24:17,800 WE ALSO INVITED THE NCATS 600 00:24:17,800 --> 00:24:21,840 ALLIANCE TO DO A TOUR OF THE 601 00:24:21,840 --> 00:24:23,480 LABS AS WELL. 602 00:24:23,480 --> 00:24:25,040 THEY CAN SEE FIRST HAND MUCH OF 603 00:24:25,040 --> 00:24:26,720 THE WORK WE DO AT THE NCATS LABS 604 00:24:26,720 --> 00:24:29,520 AND THIS IS ALSO GOING TO BE 605 00:24:29,520 --> 00:24:31,840 CRITICAL IN HELPING RELAY THE 606 00:24:31,840 --> 00:24:34,160 KEY MESSAGES TO THEM AND HELP 607 00:24:34,160 --> 00:24:35,880 THEM DO THE WORK AS WELL. 608 00:24:35,880 --> 00:24:41,200 VERY EXCITED ABOUT THIS. 609 00:24:41,200 --> 00:24:43,000 I ALSO WANTED TO HIGHLIGHT 610 00:24:43,000 --> 00:24:46,120 ANOTHER ACTIVITY WE DO AT ENACTS 611 00:24:46,120 --> 00:24:49,480 AND THIS IS -- AT NCATS AND A 612 00:24:49,480 --> 00:24:53,360 VOLUNTEER ACTIVITY WITH THE 613 00:24:53,360 --> 00:24:55,840 CHILDREN'S INN AND A DINNER IS 614 00:24:55,840 --> 00:24:57,720 ORGANIZED TWICE A YEAR AND THIS 615 00:24:57,720 --> 00:24:59,600 IS JENNY IN THE CENTER THE CEO 616 00:24:59,600 --> 00:25:01,840 AND THEY PLAY SUCH A CRITICAL 617 00:25:01,840 --> 00:25:04,400 ROLE IN BRINGING KIDS AND LIZ TO 618 00:25:04,400 --> 00:25:07,840 THE NIH CLINICAL CENTER FOR 619 00:25:07,840 --> 00:25:09,640 DOING CLINICAL TRIALS AND BEING 620 00:25:09,640 --> 00:25:13,520 INVOLVED IN CLINICAL STUDIES AND 621 00:25:13,520 --> 00:25:14,680 PROVIDE THIS WONDERFUL PLACE 622 00:25:14,680 --> 00:25:16,200 THAT HAS ALL THE COMFORTS THAT 623 00:25:16,200 --> 00:25:19,120 IS A PLACE LIKE HOME. 624 00:25:19,120 --> 00:25:21,560 I CALL THEM ONE OF THE KEY 625 00:25:21,560 --> 00:25:22,200 TRANSLATIONAL SCIENTISTS BECAUSE 626 00:25:22,200 --> 00:25:24,640 OF THIS ACTIVITY THEY DO AND SO 627 00:25:24,640 --> 00:25:26,560 IT'S ALWAYS A PLEASURE TO BE 628 00:25:26,560 --> 00:25:29,160 INVOLVED IN SERVING DINNERS AND 629 00:25:29,160 --> 00:25:31,000 INTERACTING WITH THE CHILDREN SO 630 00:25:31,000 --> 00:25:34,880 I WANTED TO HIGHLIGHT THAT TOO. 631 00:25:34,880 --> 00:25:36,640 ANOTHER KEY ACTIVITY IN TERMS OF 632 00:25:36,640 --> 00:25:38,880 OUR OUTREACH AND ENGAGEMENT IS 633 00:25:38,880 --> 00:25:41,040 WE PUBLISHED A PAPER ON 634 00:25:41,040 --> 00:25:42,240 TRANSLATIONAL SCIENCE PRINCIPLES 635 00:25:42,240 --> 00:25:44,280 THAT INCLUDES THE VISUAL ICON. 636 00:25:44,280 --> 00:25:49,360 WE'RE REVAMPING OUR INTERNAL 637 00:25:49,360 --> 00:25:50,680 NCATS CATEGORIES TO MATCH THESE 638 00:25:50,680 --> 00:25:52,600 KEY CHARACTERISTICS OF 639 00:25:52,600 --> 00:25:54,080 TRANSLATIONAL SCIENCE AND 640 00:25:54,080 --> 00:25:55,640 PRINCIPLES OF TRANSLATIONAL 641 00:25:55,640 --> 00:25:55,920 SCIENCE. 642 00:25:55,920 --> 00:25:58,440 WE HOPE THESE SMALL ITEMS WILL 643 00:25:58,440 --> 00:26:00,840 SERVE TO REMIND PEOPLE OF THE 644 00:26:00,840 --> 00:26:01,840 TRANSLATIONAL SCIENCE APPROACHES 645 00:26:01,840 --> 00:26:04,080 AND KEEP THEM ATOP OF MIND FOR 646 00:26:04,080 --> 00:26:05,360 THE WORK THEY DO. 647 00:26:05,360 --> 00:26:07,120 SO WE EXPECT TO BE ABLE TO HAND 648 00:26:07,120 --> 00:26:09,760 OUT THE MAGNETS TO PEOPLE WHEN 649 00:26:09,760 --> 00:26:14,480 WE GO TO MEETINGS OR SEE 650 00:26:14,480 --> 00:26:14,880 TRAINEES AS WELL. 651 00:26:14,880 --> 00:26:17,040 THIS IS SOMETHING WE LOOK 652 00:26:17,040 --> 00:26:20,920 FORWARD TO AND PART OF OUR 653 00:26:20,920 --> 00:26:21,520 ENGAGEMENT EFFORTS. 654 00:26:21,520 --> 00:26:23,000 I'LL BRIEFLY TOUCH ON OUR 655 00:26:23,000 --> 00:26:23,800 STRATEGIC PLANNING EFFORTS SINCE 656 00:26:23,800 --> 00:26:29,400 THIG WILL BE A DEEPER DIVE IN 657 00:26:29,400 --> 00:26:30,160 OUR NEXT SESSION. 658 00:26:30,160 --> 00:26:31,840 I WANTED TO GIVE A SENSE OF 659 00:26:31,840 --> 00:26:33,560 WHERE WE ARE WITH THE PROCESS 660 00:26:33,560 --> 00:26:37,440 AND OUR STAKEHOLDER ENGAGEMENTS. 661 00:26:37,440 --> 00:26:39,320 WE STARTED THIS IN NOTCH BER AND 662 00:26:39,320 --> 00:26:46,120 WE'RE REALLY MARCHING THROUGH 663 00:26:46,120 --> 00:26:49,840 AND WE'RE DOING AN OVERVIEW OF 664 00:26:49,840 --> 00:26:51,680 THE NCATS ACTIVES AND TALK ABOUT 665 00:26:51,680 --> 00:26:53,000 OUR GOALS AND ASK QUESTIONS WHAT 666 00:26:53,000 --> 00:26:54,640 THEY THINK ABOUT THE GOALS AND 667 00:26:54,640 --> 00:26:56,840 HOW THEY CAN PROVIDE INPUT IN 668 00:26:56,840 --> 00:26:58,360 HOW WE PROCEED IN DEVELOPING OUR 669 00:26:58,360 --> 00:27:03,800 PLAN GOING FORWARD AND WE SEE 670 00:27:03,800 --> 00:27:05,240 THIS AS AN OPPORTUNITY TO GET 671 00:27:05,240 --> 00:27:07,880 THE INPUT FROM STAKEHOLDERS TO 672 00:27:07,880 --> 00:27:09,360 ALL TAKE OWNERSHIP BECAUSE 673 00:27:09,360 --> 00:27:11,120 THAT'S THE WAY WE'LL BE MOST 674 00:27:11,120 --> 00:27:11,440 SUCCESSFUL. 675 00:27:11,440 --> 00:27:13,280 WE'RE STILL AT THE STAGE OF 676 00:27:13,280 --> 00:27:14,800 DOING THESE STAKEHOLDER 677 00:27:14,800 --> 00:27:16,240 ENGAGEMENTS BUT THEN AS WE GO 678 00:27:16,240 --> 00:27:17,480 FORWARD WHAT WE DO IN A VARIETY 679 00:27:17,480 --> 00:27:20,600 OF OTHER ACTIVITIES AND STARTING 680 00:27:20,600 --> 00:27:23,000 TO PULL THIS TOGETHER IN TERMS 681 00:27:23,000 --> 00:27:24,480 OF REQUEST FOR INFORMATION AND 682 00:27:24,480 --> 00:27:26,080 THEN THE STRATEGIC PLAN ITSELF. 683 00:27:26,080 --> 00:27:27,160 SO WE'LL TELL YOU MORE ABOUT 684 00:27:27,160 --> 00:27:28,240 THAT GOING FORWARD. 685 00:27:28,240 --> 00:27:30,760 AND YOU CAN GO TO THE NEXT 686 00:27:30,760 --> 00:27:30,960 SLIDE. 687 00:27:30,960 --> 00:27:33,520 THIS GIVES A SENSE OF ALL THE 688 00:27:33,520 --> 00:27:34,360 ENGAGEMENTS WE'VE DONE TODAY. 689 00:27:34,360 --> 00:27:35,960 I WON'T DWELL ON THIS BUT TO 690 00:27:35,960 --> 00:27:37,840 GIVE A HEADS UP THE NEXT ONE 691 00:27:37,840 --> 00:27:39,200 WILL BE WITH YOU AND WE'LL DO 692 00:27:39,200 --> 00:27:40,920 THAT IN THE NEXT HOUR OR SO. 693 00:27:40,920 --> 00:27:42,760 I LOOK FORWARD TO GETTING MORE 694 00:27:42,760 --> 00:27:51,520 OF YOUR INPUT IN THIS ACTIVITY. 695 00:27:51,520 --> 00:27:53,200 KNOW I WANT TO TRANSITION TO THE 696 00:27:53,200 --> 00:27:54,840 UPDATES IN COVID RESPONSE AND 697 00:27:54,840 --> 00:27:59,000 HAVE A COUPLE STORIES TO REPLAY. 698 00:27:59,000 --> 00:28:03,120 FIRST IS A LOT OF THESE 699 00:28:03,120 --> 00:28:04,920 ACTIVITIES ARE GOING TO CONTINUE 700 00:28:04,920 --> 00:28:12,080 BUT AS YOU KNOW MAY 11 OF 2023 701 00:28:12,080 --> 00:28:16,280 MARKED THE END OF THE COVID-19 702 00:28:16,280 --> 00:28:19,160 EMERGENCY MEDICAL AUTHORIZATION 703 00:28:19,160 --> 00:28:22,920 AND ALL THE KINDS OF COLLECTING 704 00:28:22,920 --> 00:28:26,640 DATA AS EXPIRED BUT FOR NCATS WE 705 00:28:26,640 --> 00:28:28,240 ESTABLISHED OUR OPEN DATA PORTAL 706 00:28:28,240 --> 00:28:35,120 AND YOU CAN GO TO THE PREVIOUS 707 00:28:35,120 --> 00:28:42,200 SLIDE THEY'RE NOT RELIANT ON THE 708 00:28:42,200 --> 00:28:45,440 PUBLIC HEALTH EMERGENCY THE END 709 00:28:45,440 --> 00:28:50,320 OF THE EMERGENCY DOESN'T REALLY 710 00:28:50,320 --> 00:28:51,080 AFFECT THE PROGRAMS. 711 00:28:51,080 --> 00:28:52,440 HOWEVER, FOR THE CLINICAL 712 00:28:52,440 --> 00:28:54,280 TRIALS, THIS MOMENT DOES SORT OF 713 00:28:54,280 --> 00:28:55,600 MARK THE END OF THE CLINICAL 714 00:28:55,600 --> 00:28:55,840 TRIALS. 715 00:28:55,840 --> 00:28:57,600 THE ACTIVE PROGRAM IS ON ITS 716 00:28:57,600 --> 00:29:01,240 TAIL END EXCEPT FOR ONE THING. 717 00:29:01,240 --> 00:29:03,480 THAT'S RELATED TO THE SLIDE 718 00:29:03,480 --> 00:29:09,160 PREVIOUS TO THIS. 719 00:29:09,160 --> 00:29:10,600 FOR THE CLINICAL TRIALS, MOST 720 00:29:10,600 --> 00:29:11,840 THE CLINICAL TRIALS IN THE 721 00:29:11,840 --> 00:29:14,200 ACTIVE PROGRAMS HAVE ENDED WITH 722 00:29:14,200 --> 00:29:21,720 THE EXCEPTION OF ACTIV6 WE'RE 723 00:29:21,720 --> 00:29:23,120 TESTING THE FIFTH OF FIVE DRUGS 724 00:29:23,120 --> 00:29:24,920 AND THE LAST DRUG IS GOING TO BE 725 00:29:24,920 --> 00:29:27,120 ON METFORMIN. 726 00:29:27,120 --> 00:29:28,920 THIS WILL OPEN IN JULY. 727 00:29:28,920 --> 00:29:34,760 AND THIS IS REALLY BASED ON THE 728 00:29:34,760 --> 00:29:36,920 COVID CLINICAL TRIAL RESULTS 729 00:29:36,920 --> 00:29:40,320 THAT SUGGEST ACUTE METFORMIN 730 00:29:40,320 --> 00:29:41,560 TREATMENT PREVENTS LONG COVID 731 00:29:41,560 --> 00:29:44,320 AND WE'LL LOOK AT TIME TO 732 00:29:44,320 --> 00:29:47,120 RECOVERY FROM ACUTE SYMPTOMS AND 733 00:29:47,120 --> 00:29:48,680 WILL ALSO FOLLOW PARTICIPANTS 734 00:29:48,680 --> 00:29:53,960 FOR SIX MONTHS TO SEE IF THEY 735 00:29:53,960 --> 00:29:57,040 HAVE ANYTHING RELATED TO LONG 736 00:29:57,040 --> 00:29:58,840 COVID SYMPTOMS WE CAN EVALUATE 737 00:29:58,840 --> 00:29:59,080 AS WELL. 738 00:29:59,080 --> 00:30:01,840 WE'RE ALSO INCORPORATING A 739 00:30:01,840 --> 00:30:03,680 COMPONENT WITH EVIDENCE TO LOOK 740 00:30:03,680 --> 00:30:06,600 AT LONG COVID RISK ASSOCIATED 741 00:30:06,600 --> 00:30:08,160 WITH METFORMIN USAGE WITHIN THAT 742 00:30:08,160 --> 00:30:10,080 PARTICULAR RESOURCE AS WELL. 743 00:30:10,080 --> 00:30:12,440 WE'LL BE ABLE TO LOOK BOTH AT 744 00:30:12,440 --> 00:30:15,680 THE REAL-WORLD DATA AS WELL AS 745 00:30:15,680 --> 00:30:17,720 THE CLINICAL TRIAL ITSELF AND 746 00:30:17,720 --> 00:30:19,120 IT'S AN EXCITING TRIAL WE'LL END 747 00:30:19,120 --> 00:30:29,400 OUR PROGRAM ON. 748 00:30:33,400 --> 00:30:37,840 THIS IS A SUMMARY OF THE SARS 749 00:30:37,840 --> 00:30:39,120 THERAPEUTICS TESTED AND CURATED 750 00:30:39,120 --> 00:30:40,240 OVER THE COURSE OF THE PANDEMIC 751 00:30:40,240 --> 00:30:42,080 AND HAS THE RELEVANT DATA 752 00:30:42,080 --> 00:30:43,120 ASSOCIATED WITH THAT. 753 00:30:43,120 --> 00:30:44,720 WE'LL CONTINUE TO KEEP THIS 754 00:30:44,720 --> 00:30:46,080 UPDATED AND ADD A VARIETY OF 755 00:30:46,080 --> 00:30:54,520 OTHER FEATURES AS WELL. 756 00:30:54,520 --> 00:30:55,840 I WANTED TO HIGHLIGHT AN 757 00:30:55,840 --> 00:30:56,760 INTERESTING ACTIVITY. 758 00:30:56,760 --> 00:30:58,720 THIS IS A PHONE CALL OR E-MAIL 759 00:30:58,720 --> 00:31:01,840 TO ME EARLIER THIS YEAR AND IT 760 00:31:01,840 --> 00:31:03,800 WAS A DIRECT REQUEST FROM THE 761 00:31:03,800 --> 00:31:04,480 WHITE HOUSE COVID RESPONSE TEAM 762 00:31:04,480 --> 00:31:09,600 AND THEY WERE ASKING A QUESTION 763 00:31:09,600 --> 00:31:13,320 ABOUT PAXLOVID USE AND WANTED TO 764 00:31:13,320 --> 00:31:16,240 KNOW IF USED AT ITS MAXIMUM WHAT 765 00:31:16,240 --> 00:31:17,760 IMPACT WOULD IT HAVE HAD ON 766 00:31:17,760 --> 00:31:18,480 IMPROVING OUTCOMES WITH 767 00:31:18,480 --> 00:31:18,760 COVID-19. 768 00:31:18,760 --> 00:31:20,160 THEY CHARGED US WITH ANSWERING 769 00:31:20,160 --> 00:31:22,120 SOME OF THESE QUESTIONS. 770 00:31:22,120 --> 00:31:23,120 I WANT TO WALK THROUGH WHAT 771 00:31:23,120 --> 00:31:25,520 WE'VE DONE HERE. 772 00:31:25,520 --> 00:31:28,840 OF THE 2.5 MILLION 773 00:31:28,840 --> 00:31:32,200 COVID-POSITIVE ADULTS AFTER THE 774 00:31:32,200 --> 00:31:35,400 DECEMBER 2021 RELEASE OF THE EUA 775 00:31:35,400 --> 00:31:37,000 FOR PAXLOVID. 776 00:31:37,000 --> 00:31:39,680 ABOUT HALF THE FOLKS GOING 777 00:31:39,680 --> 00:31:40,800 THROUGH THE ELIGIBILITY CRITERIA 778 00:31:40,800 --> 00:31:42,360 WERE ELIGIBLE TO RECEIVE IT 779 00:31:42,360 --> 00:31:45,000 BASED ON GUIDELINES FROM NIH AND 780 00:31:45,000 --> 00:31:47,120 THE CDC AND FDA AND THOSE ARE A 781 00:31:47,120 --> 00:31:51,120 PART OF WHAT CONTRIBUTED TO THE 782 00:31:51,120 --> 00:31:51,840 ELIGIBILITY REQUIREMENTS THAT 783 00:31:51,840 --> 00:31:53,360 WENT IN THE BOTTOM NUMBER. 784 00:31:53,360 --> 00:31:55,160 AND THERE WERE APPROXIMATELY 1.3 785 00:31:55,160 --> 00:31:57,640 MILLION ADULTS IN THIS SPACE BUT 786 00:31:57,640 --> 00:32:01,720 OF THOSE A SUBSET OF 1 MILLION 787 00:32:01,720 --> 00:32:05,360 AT THE BOTTOM MET MORE STRICT 788 00:32:05,360 --> 00:32:07,840 CRITERIA FOR TARGET TRIAL 789 00:32:07,840 --> 00:32:09,240 EMULATION IN STUDYING THIS. 790 00:32:09,240 --> 00:32:12,800 THIS IS A WAY TO LOOK AT REAL 791 00:32:12,800 --> 00:32:15,080 WORLD DATA AND THE DESIGN 792 00:32:15,080 --> 00:32:16,720 PRINCIPLES MUCH RANDOMIZED 793 00:32:16,720 --> 00:32:18,600 TRIALS BUT REALLY USING THE 794 00:32:18,600 --> 00:32:20,760 OBSERVATIONAL DATA WE HAVE IN 795 00:32:20,760 --> 00:32:22,880 HAND AND EXPLICITLY TYING THE 796 00:32:22,880 --> 00:32:24,280 OBSERVATIONAL DATA TO SORT OF 797 00:32:24,280 --> 00:32:27,280 WHAT WOULD BE A CLINICAL TRIAL. 798 00:32:27,280 --> 00:32:28,880 IT'S EMULATING THAT IDEA. 799 00:32:28,880 --> 00:32:31,400 THE PURPOSE IS TO IMPROVE THE 800 00:32:31,400 --> 00:32:32,760 QUALITY OF THESE KIND OF TRIALS 801 00:32:32,760 --> 00:32:34,120 THROUGH THE APPLICATION TRIAL 802 00:32:34,120 --> 00:32:36,040 DESIGN PRINCIPLES ESPECIALLY 803 00:32:36,040 --> 00:32:37,480 WHEN THERE'S NOTHING LIKE A 804 00:32:37,480 --> 00:32:38,040 COMPARATOR OUT THERE THAT 805 00:32:38,040 --> 00:32:41,360 EXQUISITES. 806 00:32:41,360 --> 00:32:43,320 -- EXISTS. 807 00:32:43,320 --> 00:32:45,560 WITH THIS WE WERE ABLE TO LOOK 808 00:32:45,560 --> 00:32:49,840 AT THE PAXLOVID USE AND WHAT WE 809 00:32:49,840 --> 00:32:52,520 FOUND IS THERE'S A TEMPORAL 810 00:32:52,520 --> 00:32:56,800 NATURE TO THE ROLLOUT AND THERE 811 00:32:56,800 --> 00:33:01,840 WAS AN INITIAL ROLLOUT OPTION 812 00:33:01,840 --> 00:33:02,520 AND THIS RAPID ADOPTION. 813 00:33:02,520 --> 00:33:12,360 THEN IT STARTED TO STABILIZE. 814 00:33:12,360 --> 00:33:15,040 AT THE MAXIMUM ABOUT 50% OF 815 00:33:15,040 --> 00:33:16,640 PAXLOVID UPTAKE IN CERTAIN 816 00:33:16,640 --> 00:33:20,400 PLACES WAS UP TO 50%. 817 00:33:20,400 --> 00:33:23,080 THAT SEEMED TO BE THE MAXIMAL 818 00:33:23,080 --> 00:33:23,640 CATEGORY. 819 00:33:23,640 --> 00:33:25,840 THERE WERE OTHER HEALTH CARE 820 00:33:25,840 --> 00:33:30,080 RELATED ORGANIZATIONS THAT HAD 821 00:33:30,080 --> 00:33:31,720 VARIABLE LEVELS UTILIZATION OF 822 00:33:31,720 --> 00:33:32,920 PAXLOVID AND SOME WERE QUITE 823 00:33:32,920 --> 00:33:33,240 LOW. 824 00:33:33,240 --> 00:33:37,680 ON AVERAGE IT'S THE RED BAR 825 00:33:37,680 --> 00:33:38,920 HIGHLIGHTED THERE. 826 00:33:38,920 --> 00:33:41,480 ON AVERAGE IT'S BETWEEN 9% TO 827 00:33:41,480 --> 00:33:43,160 15% OF PEOPLE ELIGIBLE GOT 828 00:33:43,160 --> 00:33:47,600 PAXLOVID. 829 00:33:47,600 --> 00:33:49,200 THERE ARE HIGH AND LOW 830 00:33:49,200 --> 00:33:50,000 PERFORMERS IN THE SPACE. 831 00:33:50,000 --> 00:33:52,000 WE WANT TO WALK THROUGH THAT 832 00:33:52,000 --> 00:33:53,720 MORE TO SHOW YOU WHAT WE MIGHT 833 00:33:53,720 --> 00:33:54,160 IDENTIFY. 834 00:33:54,160 --> 00:33:59,960 IF YOU GO TO THE NEXT SLIDE. 835 00:33:59,960 --> 00:34:01,880 THIS FIGURE WAS LOW SCORING OR 836 00:34:01,880 --> 00:34:04,080 NO SCORING AND ON A PARTICULAR 837 00:34:04,080 --> 00:34:06,080 VARIABLE ON THE LEFT-HAND SIDE 838 00:34:06,080 --> 00:34:09,120 AND GREEN MEANS YES OR HIGHER 839 00:34:09,120 --> 00:34:09,320 SCORING. 840 00:34:09,320 --> 00:34:10,880 FOR EXAMPLE, FOR AGE RED IS 841 00:34:10,880 --> 00:34:17,000 YOUNGER AND GREEN IS OLDER AND 842 00:34:17,000 --> 00:34:20,360 FOR RACE FOR WHITE RACE IS NO 843 00:34:20,360 --> 00:34:22,120 AND GREEN IS YES, WHITE. 844 00:34:22,120 --> 00:34:25,840 ZERO IS LESS LIKELY TO GET 845 00:34:25,840 --> 00:34:27,480 PAXLOVID WHEN ELIGIBLE AND RIGHT 846 00:34:27,480 --> 00:34:31,440 IS MORE LIKELY TO GET PAXLOVID. 847 00:34:31,440 --> 00:34:34,240 THIS IS WHETHER A PRESUMED 848 00:34:34,240 --> 00:34:36,400 ELIGIBLE ADULT GOT PAXLOVID OR 849 00:34:36,400 --> 00:34:38,960 NOT AROUND THIS ANALYSIS. 850 00:34:38,960 --> 00:34:42,120 SOME PREDICTABLE VARIABLES LIKE 851 00:34:42,120 --> 00:34:43,720 THE LIKELIHOOD OF GETTING 852 00:34:43,720 --> 00:34:45,080 PAXLOVID INCREASED WITH AGE. 853 00:34:45,080 --> 00:34:46,720 THIS MAKES SENSE. 854 00:34:46,720 --> 00:34:50,360 THEN THERE WERE A FEW COMOR 855 00:34:50,360 --> 00:34:53,520 COMORBIDITIES LIKE BEING 856 00:34:53,520 --> 00:34:55,880 OVERWEIGHT OR OBESE OR HAVING A 857 00:34:55,880 --> 00:34:58,440 SMOKING ILLNESS INCREASED THE 858 00:34:58,440 --> 00:34:59,920 LIKELIHOOD OF PAXLOVID AND THERE 859 00:34:59,920 --> 00:35:01,800 WERE OTHER VARIABLE. 860 00:35:01,800 --> 00:35:04,560 FOR EXAMPLE THE LONGER YOUR OVER 861 00:35:04,560 --> 00:35:05,880 ALL MEDICAL HISTORY INDICATED 862 00:35:05,880 --> 00:35:09,640 YOU WERE MORE LIKELY TO RECEIVE 863 00:35:09,640 --> 00:35:10,720 PAXLOVID RESULT. 864 00:35:10,720 --> 00:35:13,440 THESE WERE SOME OF THE FINDINGS 865 00:35:13,440 --> 00:35:18,720 WE WERE ABLE TO EVALUATE HERE. 866 00:35:18,720 --> 00:35:24,160 AND CONTRIBUTE IT TO 867 00:35:24,160 --> 00:35:28,160 UNDERSTANDING OF THE RESULTS 868 00:35:28,160 --> 00:35:33,520 HASN'T MORE AND THIS SHOWED 869 00:35:33,520 --> 00:35:35,640 PAXLOVID AND THIS IS BASED 870 00:35:35,640 --> 00:35:37,160 AROUND THE 28-DAY MORTALITY 871 00:35:37,160 --> 00:35:40,520 SHOWN ON THE BOTTOM OR REDUCED 872 00:35:40,520 --> 00:35:42,760 HOSPITALIZATION SHOWN ON THE TOP 873 00:35:42,760 --> 00:35:43,080 THERE. 874 00:35:43,080 --> 00:35:45,760 AND SO FOR PAXLOVID AND FOR 875 00:35:45,760 --> 00:35:49,160 PREVENTING HOSPITALIZATIONS AND 876 00:35:49,160 --> 00:35:51,920 DEATH YOU CAN SEE A BIT OF A 877 00:35:51,920 --> 00:35:52,680 REDUCTION IN BOTH 878 00:35:52,680 --> 00:35:53,760 HOSPITALIZATION AND MORTALITY. 879 00:35:53,760 --> 00:35:57,600 THE PANELS ON THE RIGHT-HAND 880 00:35:57,600 --> 00:35:59,600 SIDE SHOW THESE WERE ROBUST 881 00:35:59,600 --> 00:36:02,480 FINDINGS EVEN WITH THE MULTITUDE 882 00:36:02,480 --> 00:36:04,440 OF DIFFERENT SENSITIVITY KINDS 883 00:36:04,440 --> 00:36:05,960 OF ANALYSES AND DIFFERENT 884 00:36:05,960 --> 00:36:07,640 VARIABLES WE LOOKED AT. 885 00:36:07,640 --> 00:36:10,480 THESE WERE QUITE ROBUST IN THIS 886 00:36:10,480 --> 00:36:13,840 SHOWING THE NICE SEPARATION OF 887 00:36:13,840 --> 00:36:16,120 THE EFFECTIVENESS OF PAXLOVID IN 888 00:36:16,120 --> 00:36:21,320 THE REAL WORLD DATA SET. 889 00:36:21,320 --> 00:36:28,320 IF YOU GO TO THE NEXT SLIDE THIS 890 00:36:28,320 --> 00:36:30,240 SHOWS DEATHS PREVENTED AT 891 00:36:30,240 --> 00:36:36,840 INCREASING LEVELS OF PAXLOVID 892 00:36:36,840 --> 00:36:37,160 UPTAKE. 893 00:36:37,160 --> 00:36:42,560 IF WE WERE TO IF WE SENT THESE 894 00:36:42,560 --> 00:36:44,360 OUT WE CAN DO THE PROJECTIONS 895 00:36:44,360 --> 00:36:45,840 BASED ON THE DATA WE HAD. 896 00:36:45,840 --> 00:36:47,800 WE'RE ABLE TO CALCULATE THE 897 00:36:47,800 --> 00:36:49,080 NUMBER OF DEATHS AND 898 00:36:49,080 --> 00:36:51,280 HOSPITALIZATIONS PREVENTED BASED 899 00:36:51,280 --> 00:36:54,280 ON THE NATIONAL DATA FOR COVID 900 00:36:54,280 --> 00:36:55,480 CASES DURING THE FOLLOW UP 901 00:36:55,480 --> 00:36:58,720 PERIOD OF THIS STUDY AND WERE 902 00:36:58,720 --> 00:37:00,240 ABLE TO PROJECT THAT. 903 00:37:00,240 --> 00:37:02,920 WE ESTIMATED A PAXLOVID UPTAKE 904 00:37:02,920 --> 00:37:03,960 AMONG ELIGIBLE PATIENTS 905 00:37:03,960 --> 00:37:06,120 INCREASED FROM 9% AS WAS 906 00:37:06,120 --> 00:37:10,480 OBSERVED IN OUR STUDY TO 50%. 907 00:37:10,480 --> 00:37:13,840 THEN OF THE PEOPLE ELIGIBLE TO 908 00:37:13,840 --> 00:37:16,520 RECEIVE PAXLOVID DURING THE 909 00:37:16,520 --> 00:37:20,640 FOLLOW-UP PERIOD APPROXIMATELY 910 00:37:20,640 --> 00:37:22,040 48,000 AND 135,000 911 00:37:22,040 --> 00:37:25,680 HOSPITALIZATIONS COULD HAVE BEEN 912 00:37:25,680 --> 00:37:26,240 PREVENTED. 913 00:37:26,240 --> 00:37:29,640 THIS IS STRIKING DATA FROM N3C 914 00:37:29,640 --> 00:37:31,200 AND TO PUT IT IN CONTEXT. 915 00:37:31,200 --> 00:37:33,440 I RECEIVED THIS REQUEST FROM THE 916 00:37:33,440 --> 00:37:35,120 WHITE HOUSE ON MARCH 1 AND 917 00:37:35,120 --> 00:37:38,200 DISCUSSED IT WITH MIKE CORILLA 918 00:37:38,200 --> 00:37:39,840 AND ASKED THEM TO PULL THE 919 00:37:39,840 --> 00:37:40,960 DESIGN TOGETHER WITH OUR 920 00:37:40,960 --> 00:37:43,840 INTERNAL TEAM AND PRESENT THE 921 00:37:43,840 --> 00:37:47,120 RESULTS TO THE TEAM IN MID APRIL 922 00:37:47,120 --> 00:37:49,600 AND WE FINALIZED THE SUBMISSION 923 00:37:49,600 --> 00:37:53,360 WHICH SHOULD BE IN META-ARCHIVE 924 00:37:53,360 --> 00:37:53,560 TODAY. 925 00:37:53,560 --> 00:37:55,720 I CAN'T SHOW THE QR CODE BUT 926 00:37:55,720 --> 00:37:58,080 HOPEFULLY IT WILL BE UP SOON. 927 00:37:58,080 --> 00:37:59,760 OUR NCATS TEAM ANSWERED THE CALL 928 00:37:59,760 --> 00:38:03,640 FOR THIS IMPORTANT INSIGHT THAT 929 00:38:03,640 --> 00:38:05,520 WOULD NOT HAVE BEEN POSSIBLE 930 00:38:05,520 --> 00:38:07,400 WITHOUT N3C AND THE REAL WORLD 931 00:38:07,400 --> 00:38:10,960 DATA RESOURCE AND CREDIT TO THE 932 00:38:10,960 --> 00:38:13,840 GROUP ON THE SLIDE. 933 00:38:13,840 --> 00:38:15,480 [LISTING NAMES] 934 00:38:15,480 --> 00:38:18,880 THIS IS A TESTAMENT TOLL CTSA 935 00:38:18,880 --> 00:38:21,520 GROUP AND CTR PROGRAM AND 936 00:38:21,520 --> 00:38:22,680 COLLABORATORS AND THE THOUSANDS 937 00:38:22,680 --> 00:38:24,360 OF PEOPLE WHO MADE IT POSSIBLE. 938 00:38:24,360 --> 00:38:27,200 IT'S A POWERFUL EXAMPLE OF HOW 939 00:38:27,200 --> 00:38:30,360 IMPORTANT THEY CAN BE TO PROVIDE 940 00:38:30,360 --> 00:38:31,800 INSIGHT WE WOULDN'T BE ABLE TO 941 00:38:31,800 --> 00:38:32,600 DO OTHERWISE. 942 00:38:32,600 --> 00:38:35,120 I WANTED TO GIVE YOU A DEEP 943 00:38:35,120 --> 00:38:36,560 SENSE OF THAT PARTICULAR WORK 944 00:38:36,560 --> 00:38:37,160 AND ACTIVITY THAT WE'VE BEEN 945 00:38:37,160 --> 00:38:41,560 DOING. 946 00:38:41,560 --> 00:38:43,080 LET'S GO TO THE NEXT SLIDE. 947 00:38:43,080 --> 00:38:45,680 I ALSO WANTED TO GIVE A SENSE OF 948 00:38:45,680 --> 00:38:47,160 THE OTHER IMPACTFUL STUDIES 949 00:38:47,160 --> 00:38:56,280 BEFORE ENDING THE SESSION. 950 00:38:56,280 --> 00:38:59,480 I WANTED TO HIGHLIGHT THE 951 00:38:59,480 --> 00:39:02,440 TRENDING AND EDUCATION SPACE FOR 952 00:39:02,440 --> 00:39:04,480 YOUNG PEOPLE AND ADVANCING THE 953 00:39:04,480 --> 00:39:06,880 CAREERS OF WOMEN IN BIO 954 00:39:06,880 --> 00:39:07,160 MEDICINE. 955 00:39:07,160 --> 00:39:10,720 WE HAVE A WOMAN SCIENTIST 956 00:39:10,720 --> 00:39:13,360 ADVISERS GROUP AND THEY GIVE OUT 957 00:39:13,360 --> 00:39:16,360 THE NEW INITIATIVE IN 2022 THAT 958 00:39:16,360 --> 00:39:17,680 PROVIDES OUTREACH AND ENGAGEMENT 959 00:39:17,680 --> 00:39:22,240 TO LOCAL COMMUNITIES AND KIDS IN 960 00:39:22,240 --> 00:39:24,400 KIDS GRADE K-12 FOR TALKING 961 00:39:24,400 --> 00:39:25,840 ABOUT SCIENCE AND BRINGING THEM 962 00:39:25,840 --> 00:39:28,440 IN TO LOOK AT LABS AND THIS IS A 963 00:39:28,440 --> 00:39:31,320 WAY TO INCREASE OUR VISIBILITY 964 00:39:31,320 --> 00:39:31,800 WITH THE FUTURE WOMEN 965 00:39:31,800 --> 00:39:39,840 SCIENTISTS. 966 00:39:39,840 --> 00:39:44,720 I WANT TO ALSO NOTE THAT AS MANY 967 00:39:44,720 --> 00:39:47,720 MAY REMEMBER DR. BECKY JACKSON 968 00:39:47,720 --> 00:39:49,640 WAS AN A PART OF OUR NCATS 969 00:39:49,640 --> 00:39:52,720 COUNCIL AND DIED UNFORTUNATELY 970 00:39:52,720 --> 00:39:53,560 LAST YEAR. 971 00:39:53,560 --> 00:39:58,200 THE ACTS GROUP HAS DEDICATED 972 00:39:58,200 --> 00:39:59,120 THEIR TRANSLATIONAL RESEARCH 973 00:39:59,120 --> 00:40:00,840 DISTINGUISHED EDUCATOR AWARD TO 974 00:40:00,840 --> 00:40:04,240 THE MEMORY OF BECKY JACKSON FOR 975 00:40:04,240 --> 00:40:06,640 OUTSTANDING ACHIEVEMENT IN 976 00:40:06,640 --> 00:40:07,120 EDUCATION INNOVATION. 977 00:40:07,120 --> 00:40:08,600 I WANTED TO HIGHLIGHT THE FIRST 978 00:40:08,600 --> 00:40:11,120 PERSON WHO RECEIVE THE AWARD, 979 00:40:11,120 --> 00:40:15,160 CYNTHIA MORE IS RECEIVED THIS 980 00:40:15,160 --> 00:40:19,120 ACHIEVEMENT IN EDUCATION 981 00:40:19,120 --> 00:40:22,560 INNOVATION AND CONGRATULATE HER 982 00:40:22,560 --> 00:40:23,640 FOR THEIR IMPACT IN THE FIELD 983 00:40:23,640 --> 00:40:25,280 WITH THE WORK. 984 00:40:25,280 --> 00:40:28,280 I WANTED TO HIGHLIGHT A FEW 985 00:40:28,280 --> 00:40:28,560 SCHOLARS. 986 00:40:28,560 --> 00:40:37,320 THIS IS CAROLINE HSU LOOKING AT 987 00:40:37,320 --> 00:40:39,120 SARS COV2 IN AND HAS FOUND AMONG 988 00:40:39,120 --> 00:40:42,400 PATIENTS WHO RECEIVED 989 00:40:42,400 --> 00:40:43,880 MAINTENANCE DIALYSIS THERE'S 990 00:40:43,880 --> 00:40:46,960 STILL A HIGH RATE OF COV2 991 00:40:46,960 --> 00:40:49,040 INFECTIONS AND SUPPORTS THE ROLE 992 00:40:49,040 --> 00:40:51,800 FOR MASKING AND PERHAPS OTHER 993 00:40:51,800 --> 00:40:52,800 RECAUTIONS AND CONTINUING HOW TO 994 00:40:52,800 --> 00:40:58,080 CONTINUE THE VACCINES SO THAT IN 995 00:40:58,080 --> 00:41:01,000 CASE THE TIDERS WANE OVERTIME 996 00:41:01,000 --> 00:41:03,400 FOR THOSE VULNERABLE THIS IS 997 00:41:03,400 --> 00:41:07,080 IMPORTANT WORK SHE'S IDENTIFIED. 998 00:41:07,080 --> 00:41:08,720 SHE LOOKED AT THIS POPULATION 999 00:41:08,720 --> 00:41:11,120 AND SAW IT AS A VULNERABILITY 1000 00:41:11,120 --> 00:41:17,120 NOR POPULATIONS AND CREATING THE 1001 00:41:17,120 --> 00:41:20,480 DISSEMINATION TO PROTECT MOST AT 1002 00:41:20,480 --> 00:41:21,880 RISK FROM SARS COV2 INFECTION. 1003 00:41:21,880 --> 00:41:30,640 ANOTHER SCOL HOLAR I WANTED TO 1004 00:41:30,640 --> 00:41:33,160 HIGHLIGHT IS JILL ROBERTS IS 1005 00:41:33,160 --> 00:41:36,600 LOOKING AT MOIA MOIA SYNDROME 1006 00:41:36,600 --> 00:41:39,360 WHICH MEANS PUFF OF SMOKE IN 1007 00:41:39,360 --> 00:41:39,880 JAPANESE. 1008 00:41:39,880 --> 00:41:41,640 THIS IS WHEN BLOOD VESSELS LOOK 1009 00:41:41,640 --> 00:41:44,280 LIKE A PUFF OF SMOKE ESSENTIALLY 1010 00:41:44,280 --> 00:41:47,800 ON AN ANGIOGRAM. 1011 00:41:47,800 --> 00:41:50,960 A FAIRLY RARE CONDITION AND HAS 1012 00:41:50,960 --> 00:41:53,120 A MOUSE MODEL WHERE SHE PUTS 1013 00:41:53,120 --> 00:41:54,480 COILS AROUND THE BLOOD VESSELS 1014 00:41:54,480 --> 00:41:55,880 TO RESTRICT THEM AND CREATE A 1015 00:41:55,880 --> 00:41:59,520 MOUSE MODEL. 1016 00:41:59,520 --> 00:42:01,600 SHE'S SET TO TEST THIS AND OTHER 1017 00:42:01,600 --> 00:42:03,680 TYPES OF COMORBID CONDITIONS 1018 00:42:03,680 --> 00:42:06,160 BECAUSE PEOPLE TYPICALLY WITH 1019 00:42:06,160 --> 00:42:11,960 THIS DISEASE HAVE AN INCREASED 1020 00:42:11,960 --> 00:42:13,000 PREVALENCE OF AUTOIMMUNITY AND 1021 00:42:13,000 --> 00:42:17,760 DIABETES AND THERE'S A TEN-FOLD 1022 00:42:17,760 --> 00:42:20,920 RATE OF MOYAMOYA DECEASE IN 1023 00:42:20,920 --> 00:42:23,080 KENTUCKY AND ABLE TO CREATE THE 1024 00:42:23,080 --> 00:42:25,400 MOUSE MODEL AND HOPEFULLY 1025 00:42:25,400 --> 00:42:25,960 DEVELOP TREATMENTS FOR THE 1026 00:42:25,960 --> 00:42:26,840 DISEASE SHORTLY. 1027 00:42:26,840 --> 00:42:34,720 MORE TO COME ON THAT. 1028 00:42:34,720 --> 00:42:38,360 THIS IS A STORY OF KIM STINGER 1029 00:42:38,360 --> 00:42:41,960 THE ONLY PERSON IN THE WORLD WHO 1030 00:42:41,960 --> 00:42:47,120 HAS SOMETHING CALLED COMPLETE 1031 00:42:47,120 --> 00:42:55,120 SENSORY NEUROPATHY AND NO SENSE 1032 00:42:55,120 --> 00:42:59,280 OR SENSATION AND SOME ARE TRYING 1033 00:42:59,280 --> 00:43:04,560 TO HELP KIM UNDERSTAND HER 1034 00:43:04,560 --> 00:43:04,840 CONDITION. 1035 00:43:04,840 --> 00:43:11,880 THEY'VE CREATED A DOCUMENTARY ON 1036 00:43:11,880 --> 00:43:14,080 THE QR CODE AND CBS DID A 1037 00:43:14,080 --> 00:43:14,840 PROGRAM AS WELL ON THE LOWER 1038 00:43:14,840 --> 00:43:16,000 LEFT CORNER. 1039 00:43:16,000 --> 00:43:18,560 IT'S A TWO-MINUTE VIDEO TRAILER. 1040 00:43:18,560 --> 00:43:20,440 I ENCOURAGE YOU TO TAKE A LOOK 1041 00:43:20,440 --> 00:43:22,680 AT IT AND LEAVE YOU ROOTING FOR 1042 00:43:22,680 --> 00:43:24,680 KIM AND PEGGY AND WANTING TO 1043 00:43:24,680 --> 00:43:26,880 LEARN MORE ABOUT THE DISEASE AND 1044 00:43:26,880 --> 00:43:32,400 IT HAS A BIG IMPACT HOW THE WORK 1045 00:43:32,400 --> 00:43:33,280 CAN ALSO INFLUENCE AND SPORT 1046 00:43:33,280 --> 00:43:34,880 SCIENCE BECAUSE OF THE HOPE AND 1047 00:43:34,880 --> 00:43:37,200 IMPACT IT CAN HAVE ON LIVES FOR 1048 00:43:37,200 --> 00:43:38,320 PEOPLE WITH SIMILAR CONDITIONS 1049 00:43:38,320 --> 00:43:38,520 AS WELL. 1050 00:43:38,520 --> 00:43:44,640 THIS SANE INTERESTING STORY. 1051 00:43:44,640 --> 00:43:46,760 ON THE NEXT SLIDE I WANT TO 1052 00:43:46,760 --> 00:43:48,880 HIGHLIGHT ANOTHER FOUR-MINUTE 1053 00:43:48,880 --> 00:43:49,880 VIDEO. 1054 00:43:49,880 --> 00:43:52,360 THE EXECUTIVE DIRECTOR OF THE 1055 00:43:52,360 --> 00:43:53,920 HEALTH EDUCATION COUNCIL OF 1056 00:43:53,920 --> 00:43:55,120 CALIFORNIA AND MEMBER OF THE 1057 00:43:55,120 --> 00:43:57,600 U.C. DAVIS CENTER FOR REDUCING 1058 00:43:57,600 --> 00:44:00,720 HEALTH DISPARITIES AND CTSA AND 1059 00:44:00,720 --> 00:44:01,840 COMMUNITY ADVISORY BOARD MEMBER 1060 00:44:01,840 --> 00:44:04,640 AS WELL. 1061 00:44:04,640 --> 00:44:07,280 THIS PROJECT WAS INCLUDED IN THE 1062 00:44:07,280 --> 00:44:09,520 NATIONAL ACADEMY PROGRAM ON 1063 00:44:09,520 --> 00:44:11,520 ASSESSING MEANINGFUL COMMUNITY 1064 00:44:11,520 --> 00:44:14,640 ENGAGEMENT. 1065 00:44:14,640 --> 00:44:17,360 THEY RECENTLY RELEASED THESE 1066 00:44:17,360 --> 00:44:18,360 ASSESSMENT INSTRUMENTS THAT WILL 1067 00:44:18,360 --> 00:44:19,920 BE IMPORTANT FOR THE COMMUNITY 1068 00:44:19,920 --> 00:44:21,640 ENGAGEMENT PROGRAMS WE ALL DO. 1069 00:44:21,640 --> 00:44:31,120 I WANT TO THANK SPECIFICALLY 1070 00:44:31,120 --> 00:44:41,480 SERGIO AGUILAR-GAXIOLA AND THEY 1071 00:44:41,480 --> 00:44:44,520 LOOKED AT A FOOD DESERT IN 1072 00:44:44,520 --> 00:44:45,720 NORTHERN CALIFORNIA AND FOUND IT 1073 00:44:45,720 --> 00:44:47,720 WASN'T THE ISSUE. 1074 00:44:47,720 --> 00:44:49,040 IT'S MORE OF A COMMUNITY FEELING 1075 00:44:49,040 --> 00:44:53,840 SAFE AND CONNECTED AND THE 1076 00:44:53,840 --> 00:44:56,640 ABILITY TO WALK AROUND ON 1077 00:44:56,640 --> 00:44:58,760 PAVEMENT THAT IS WELL CARED FOR 1078 00:44:58,760 --> 00:45:00,200 TO PUSH STROLLERS AND NAVIGATE 1079 00:45:00,200 --> 00:45:00,680 THE COMMUNITY. 1080 00:45:00,680 --> 00:45:02,520 THIS IS WHAT IT'S REALLY ABOUT 1081 00:45:02,520 --> 00:45:03,880 AND THIS WAS A LOT OF WORK 1082 00:45:03,880 --> 00:45:06,200 CONDUCTED THROUGH THIS AND THE 1083 00:45:06,200 --> 00:45:07,600 VIDEO'S JUST A COMPELLING STORY 1084 00:45:07,600 --> 00:45:11,080 WHY THIS WORK IS SO IMPORTANT. 1085 00:45:11,080 --> 00:45:13,120 I WANTED TO GIVE YOU A SENSE OF 1086 00:45:13,120 --> 00:45:13,320 THAT. 1087 00:45:13,320 --> 00:45:22,080 THE NEXT STOREYY -- STORY IS TH 1088 00:45:22,080 --> 00:45:23,520 HEALTH SCIENCES AND INNOVATION 1089 00:45:23,520 --> 00:45:24,760 ENTREPRENEUR PROGRAM THROUGH THE 1090 00:45:24,760 --> 00:45:33,680 CTSA OUT OF UMAS AND TWO ARE 1091 00:45:33,680 --> 00:45:37,640 STUDY A DRUG THAT'S SUPPOSED TO 1092 00:45:37,640 --> 00:45:37,840 HELP. 1093 00:45:37,840 --> 00:45:38,840 BUPRENORPHINE IS SUPPOSED TO 1094 00:45:38,840 --> 00:45:44,680 HELP OPIOID ADDICTION AND 1095 00:45:44,680 --> 00:45:45,280 WITHDRAWAL AND WHAT HAPPENS 1096 00:45:45,280 --> 00:45:51,120 THOUGH IN PREGNANCY THERE'S AN 1097 00:45:51,120 --> 00:45:57,160 ACTIVE METABLITE AND IT'S 1098 00:45:57,160 --> 00:45:59,040 INDICATED WHEN TAKEN DURING 1099 00:45:59,040 --> 00:46:01,560 PREGNANCY AND REDUCING OR 1100 00:46:01,560 --> 00:46:03,800 ELIMINATING THAT BUPRENORPHINE 1101 00:46:03,800 --> 00:46:06,560 METABOLITE IS IMPORTANT TO HELP 1102 00:46:06,560 --> 00:46:09,040 IMPACT THE NEONATAL OPIOID 1103 00:46:09,040 --> 00:46:10,840 WITHDRAWING SIN DOME ISSUE. 1104 00:46:10,840 --> 00:46:13,640 WHAT THEY'VE DONE IS ESSENTIALLY 1105 00:46:13,640 --> 00:46:18,320 CREATED A FORM OF BUPRENORPHINE 1106 00:46:18,320 --> 00:46:21,080 AND THE FORM DOESN'T GET 1107 00:46:21,080 --> 00:46:23,120 METABOLIZED SO IT'S A WAY FOR 1108 00:46:23,120 --> 00:46:25,440 PREGNANT INDIVIDUALS TO BE ABLE 1109 00:46:25,440 --> 00:46:27,120 TO UNDER GO WITHDRAWING MORE 1110 00:46:27,120 --> 00:46:31,560 SAFELY AND NOT AFFECT THE AS 1111 00:46:31,560 --> 00:46:31,760 MUCH. 1112 00:46:31,760 --> 00:46:33,760 THEY'VE DIN THE WORK IN MOUSE 1113 00:46:33,760 --> 00:46:41,680 MODELS AND LOOKING TO FOREIT 1114 00:46:41,680 --> 00:46:42,440 FORWF -- 1115 00:46:42,440 --> 00:46:43,880 MORE IT FORWARD. 1116 00:46:43,880 --> 00:46:46,840 AS THE EXCITING. 1117 00:46:46,840 --> 00:46:48,160 SPEAKING OF COMMERCIALIZATION I 1118 00:46:48,160 --> 00:46:49,960 WANT TO MENTION ONE MORE IN THIS 1119 00:46:49,960 --> 00:46:50,480 AREA. 1120 00:46:50,480 --> 00:46:51,960 THIS IS ONE OF THE SPIR SUCCESS 1121 00:46:51,960 --> 00:46:55,240 STORIES I MENTIONED. 1122 00:46:55,240 --> 00:46:57,440 A SMALL BUSINESS PROGRAM AND 1123 00:46:57,440 --> 00:47:01,320 THIS IS REALLY A GREAT RESOURCE 1124 00:47:01,320 --> 00:47:03,120 FOR SMALL BUSINESSES AND THE 1125 00:47:03,120 --> 00:47:06,760 STIR PROGRAM. 1126 00:47:06,760 --> 00:47:09,720 THIS PARTICULAR GROUP IN 2018 1127 00:47:09,720 --> 00:47:12,400 AND 2021 PROVIDED ABOUT $2 1128 00:47:12,400 --> 00:47:15,160 MILLION OF SPIR GRANTS TO 1129 00:47:15,160 --> 00:47:18,120 DEVELOP A PROTOTYPE DEVICE FOR 1130 00:47:18,120 --> 00:47:20,960 MOLECULAR STRUCTURES IN A 1131 00:47:20,960 --> 00:47:22,440 STREAMLINED WAY AND AUTOMATED 1132 00:47:22,440 --> 00:47:23,320 WAY AND IT TO THE CLIN IKDZ 1133 00:47:23,320 --> 00:47:25,720 FASTER. 1134 00:47:25,720 --> 00:47:30,520 -- CLINICS FURTHER AND THE 1135 00:47:30,520 --> 00:47:33,120 REFINE THE DEVICE AND HOOKED IT 1136 00:47:33,120 --> 00:47:43,000 UP WITH MASS SPECTOMETRY AND 1137 00:47:43,000 --> 00:47:47,120 THEY WERE BOUGHT AS PART OF A 1138 00:47:47,120 --> 00:47:57,440 $40 MILLION DEAL. 1139 00:47:59,720 --> 00:48:01,320 AND THEY'RE MOVING FORWARD IN 1140 00:48:01,320 --> 00:48:02,920 THE FIELD AND A WANTED TO 1141 00:48:02,920 --> 00:48:03,520 HIGHLIGHT THAT AS WELL. 1142 00:48:03,520 --> 00:48:06,400 TO ROUND OUT THIS IS THE LAST 1143 00:48:06,400 --> 00:48:11,760 GROUP -- THING I WANTED TO TALK 1144 00:48:11,760 --> 00:48:18,680 ABOUT BUT THE LAST IS AN 1145 00:48:18,680 --> 00:48:20,400 INTERSECTION BETWEEN THE 1146 00:48:20,400 --> 00:48:21,640 BIOLODGICS AND RARELIEDS. 1147 00:48:21,640 --> 00:48:24,480 PULLING IT TOGETHER AND MOVING 1148 00:48:24,480 --> 00:48:27,440 IT IN THE GENE THERAPY SPACE. 1149 00:48:27,440 --> 00:48:33,200 I'M GIVING A TEASE ER OF WHAT 1150 00:48:33,200 --> 00:48:35,440 YOU'LL HEAR FROM PJ BROOKS. 1151 00:48:35,440 --> 00:48:37,600 WE LEAD EFFORTS AND THE MAIN 1152 00:48:37,600 --> 00:48:41,120 PROGRAMS ARE SHOWN HERE AND THEY 1153 00:48:41,120 --> 00:48:42,520 SPAN THE CLINICAL TRIAL 1154 00:48:42,520 --> 00:48:43,960 READINESS AREAS AND RANGE FROM 1155 00:48:43,960 --> 00:48:48,320 SORT OF EARLY ON IN DEVELOPMENT 1156 00:48:48,320 --> 00:48:50,480 STAGES LIKE THE EDITING PROGRAM 1157 00:48:50,480 --> 00:48:54,600 AND SOMEWHERE IN THE MIDDLE THE 1158 00:48:54,600 --> 00:48:57,760 BESPOKE GENE THERAPY CONSORTIUM 1159 00:48:57,760 --> 00:49:01,240 AND THE PLATFORM VECTOR GENE 1160 00:49:01,240 --> 00:49:03,080 THERAPY PROGRAMMING ON TRACK TO 1161 00:49:03,080 --> 00:49:04,240 PERFORM A CLINICAL TRIAL NEXT 1162 00:49:04,240 --> 00:49:06,160 YEAR AND IN NCATS WE TALK ABOUT 1163 00:49:06,160 --> 00:49:07,880 THE SCIENTIFIC AND OPERATIONAL 1164 00:49:07,880 --> 00:49:09,000 CHALLENGES WE HAVE. 1165 00:49:09,000 --> 00:49:10,160 AND THESE ARE THE KEY THINGS 1166 00:49:10,160 --> 00:49:11,600 WE'RE TRYING TO ADDRESS IN TERMS 1167 00:49:11,600 --> 00:49:15,000 OF BOTTLE NECKS AND THE 1168 00:49:15,000 --> 00:49:16,200 PRINCIPLES WE'RE TRYING TO PUSH 1169 00:49:16,200 --> 00:49:17,920 AND THIS IS REALLY ADDRESSING 1170 00:49:17,920 --> 00:49:20,920 BOTH THE SCIENTIFIC AND 1171 00:49:20,920 --> 00:49:22,400 OPERATIONAL BOTTLE NECKS BUT 1172 00:49:22,400 --> 00:49:24,680 I'LL HIGHLIGHT THE OPERATIONAL 1173 00:49:24,680 --> 00:49:26,480 PIECE AND THE PIECE I WANT TO 1174 00:49:26,480 --> 00:49:26,960 MENTION HERE. 1175 00:49:26,960 --> 00:49:30,000 WE INITIATED THE COLLABORATION 1176 00:49:30,000 --> 00:49:34,760 WITH NIGRI AND NINDS AND THE 1177 00:49:34,760 --> 00:49:36,040 CLINICAL TRIAL CENTER TO START 1178 00:49:36,040 --> 00:49:37,880 THE PROGRAM INTENDED TO DEVELOP 1179 00:49:37,880 --> 00:49:40,880 GENE THERAPIES FOR FOUR RARE 1180 00:49:40,880 --> 00:49:41,160 DISEASES. 1181 00:49:41,160 --> 00:49:46,880 AS A UNIQUE PART OF THE PROGRAM 1182 00:49:46,880 --> 00:49:49,720 WE SET OUT TO PUBLIC SHARE THE 1183 00:49:49,720 --> 00:49:50,520 REGULATORY EXPERIENCE WE GAINED 1184 00:49:50,520 --> 00:49:51,320 AT DIFFERENT STAGES ALONG THE 1185 00:49:51,320 --> 00:49:55,960 WAY FOR IMPLEMENTING THE PAGT 1186 00:49:55,960 --> 00:49:56,600 PLATFORM. 1187 00:49:56,600 --> 00:50:01,880 EARLIER THIS YEAR THE TEAM 1188 00:50:01,880 --> 00:50:04,840 OBTAINED ORPHAN DRUG DESIGNATION 1189 00:50:04,840 --> 00:50:11,080 AND RARE PEDIATRIC DISEASE TO 1190 00:50:11,080 --> 00:50:15,680 TREAT PROPIONIC ISCHEMIA AND 1191 00:50:15,680 --> 00:50:20,320 WE'RE GIVING AN INCREASE IN THE 1192 00:50:20,320 --> 00:50:22,480 ORE FIN DRUG AND RARE PERIOD 1193 00:50:22,480 --> 00:50:25,560 TRICK DISEASE DESIGNATIONS FOR 1194 00:50:25,560 --> 00:50:27,360 GENE THERAPY ESPECIALLY FROM 1195 00:50:27,360 --> 00:50:28,000 SMALL COMPANIES. 1196 00:50:28,000 --> 00:50:30,200 WE FEEL COMPELLED TO MAKE THE 1197 00:50:30,200 --> 00:50:31,560 TEMPLATES WE'VE DONE IN OUR 1198 00:50:31,560 --> 00:50:32,400 CONVERSATIONS WITH THE FDA 1199 00:50:32,400 --> 00:50:42,800 AVAILABLE TO THE PUBLIC. 1200 00:50:58,160 --> 00:51:01,760 WE'RE PROUD OF THIS WORK AND A 1201 00:51:01,760 --> 00:51:03,120 WANT TO THANK THOSE WHO LED THE 1202 00:51:03,120 --> 00:51:06,240 EFFORT AND COLLABORATING WITH 1203 00:51:06,240 --> 00:51:08,560 OUR NCATS TEAM AND STRATEGIC 1204 00:51:08,560 --> 00:51:11,240 ALLIANCES AND OTHERS IN DIDRI. 1205 00:51:11,240 --> 00:51:13,120 COULD BE CONGRATULATIONS TO THEM 1206 00:51:13,120 --> 00:51:13,880 FOR THE GAME CHANGING KIND OF 1207 00:51:13,880 --> 00:51:18,480 WORK. 1208 00:51:18,480 --> 00:51:20,720 I'LL STOP THERE AND OPEN IT UP 1209 00:51:20,720 --> 00:51:22,000 IN CASE ANYBODY HAS ANY 1210 00:51:22,000 --> 00:51:22,400 QUESTIONS. 1211 00:51:22,400 --> 00:51:28,520 THIS IS A SUMMARY OF WHAT WE 1212 00:51:28,520 --> 00:51:35,200 TALKED ABOUT AND THE NOMINATION 1213 00:51:35,200 --> 00:51:36,520 OF THE NIH DIRECTOR AND THE 1214 00:51:36,520 --> 00:51:39,480 ROCKET LAUNCHES AND LOTS OF 1215 00:51:39,480 --> 00:51:44,840 IMPACTFUL ADVANCES WE'RE VERY 1216 00:51:44,840 --> 00:51:49,920 EXCITED ABOUT AND THE STRATEGIC 1217 00:51:49,920 --> 00:51:56,560 PLANNING DISCUSSIONS. 1218 00:51:56,560 --> 00:52:07,040 UP NEXT YOU'LL HEAR DR. EWY 1219 00:52:12,600 --> 00:52:13,480 MATHE. 1220 00:52:13,480 --> 00:52:14,800 I'M HAPPY TO QUESTIONS AND NOTE 1221 00:52:14,800 --> 00:52:16,200 WE HAVE SPECIAL TIME AT THE END 1222 00:52:16,200 --> 00:52:19,040 OF THE DAY GIVEN ALL THE UPDATES 1223 00:52:19,040 --> 00:52:22,520 TO CONTINUE THE DISCUSSION THEN 1224 00:52:22,520 --> 00:52:31,760 AS WELL SO WE CAN STAY ON TRACK. 1225 00:52:31,760 --> 00:52:34,600 >>I SEE YOU. 1226 00:52:34,600 --> 00:52:39,920 >>THAT'S A GREAT PRESENTATION 1227 00:52:39,920 --> 00:52:43,120 AND TOUR DE FORCE, 1228 00:52:43,120 --> 00:52:43,480 CONGRATULATIONS. 1229 00:52:43,480 --> 00:52:46,600 I I WANT TO TALK ABOUT WHERE THE 1230 00:52:46,600 --> 00:52:47,240 COLLABORATIVE DISCUSSION WITH 1231 00:52:47,240 --> 00:52:49,880 ARPA-H WHERE THEY'RE HEADING AND 1232 00:52:49,880 --> 00:52:54,800 THE TIME FRAME ON THAT. 1233 00:52:54,800 --> 00:52:56,560 >>THANK YOU FOR THAT. 1234 00:52:56,560 --> 00:53:02,160 IT'S STILL NEUTRAL -- EARLY 1235 00:53:02,160 --> 00:53:02,360 DAYS. 1236 00:53:02,360 --> 00:53:05,000 THEY HAVE ONE ON OSTEOARTHRITIS 1237 00:53:05,000 --> 00:53:06,320 AND ONE ON CANCER. 1238 00:53:06,320 --> 00:53:08,200 SO I THINK THEY'LL BE FOCUSSING 1239 00:53:08,200 --> 00:53:09,280 SOME OF THEIR EFFORTS LARGELY ON 1240 00:53:09,280 --> 00:53:11,960 THAT AND SOME OF THE DISCUSSIONS 1241 00:53:11,960 --> 00:53:13,360 WE'VE HAD WITH THEM ARE AROUND A 1242 00:53:13,360 --> 00:53:15,120 VARIETY OF OTHER ACTIVITIES AS 1243 00:53:15,120 --> 00:53:18,800 WELL BUT WHERE WE MIGHT BE ABLE 1244 00:53:18,800 --> 00:53:21,840 TO CONTRIBUTE TO THAT WORK THERE 1245 00:53:21,840 --> 00:53:22,760 MIGHT BE OPPORTUNITIES WITHIN 1246 00:53:22,760 --> 00:53:24,120 THE REAL WORLD DATA ASPECTS THAT 1247 00:53:24,120 --> 00:53:24,680 WE HAVE. 1248 00:53:24,680 --> 00:53:27,680 THOSE ARE THE KINDS OF 1249 00:53:27,680 --> 00:53:29,120 DISCUSSIONS WE DON'T HAVE 1250 00:53:29,120 --> 00:53:30,240 ANYTHING SET IN STONE JUST YET 1251 00:53:30,240 --> 00:53:31,560 BUT HAVING THOSE DISCUSSIONS AND 1252 00:53:31,560 --> 00:53:32,880 CONTINUING THAT ENGAGEMENT HAS 1253 00:53:32,880 --> 00:53:35,080 BEEN VERY PRODUCTIVE AND 1254 00:53:35,080 --> 00:53:37,880 COLLABORATIVE AND SO I THINK 1255 00:53:37,880 --> 00:53:39,760 THIS WILL MOVE FORWARD. 1256 00:53:39,760 --> 00:53:42,400 HOPEFULLY WE'LL HAVE MORE TO 1257 00:53:42,400 --> 00:53:45,200 TALK ABOUT AS IT CONTINUES TO 1258 00:53:45,200 --> 00:53:47,760 GROW AND THEY GET MORE PROGRAM 1259 00:53:47,760 --> 00:53:49,160 MANAGERS AS WELL IN THEIR SPACE. 1260 00:53:49,160 --> 00:53:52,680 AS YOU PROBABLY KNOW THEY HAVE A 1261 00:53:52,680 --> 00:53:55,120 LITTLE BIT DIFFERENT WAY OF 1262 00:53:55,120 --> 00:53:58,160 APPROACHING THE WORK THEY DO. 1263 00:53:58,160 --> 00:53:59,560 IT'S PROGRAM MANAGER DRIVEN. 1264 00:53:59,560 --> 00:54:01,440 THEY BRING PROGRAM MANGERS IN 1265 00:54:01,440 --> 00:54:03,080 AND THAT'S WHEN THEY START TO 1266 00:54:03,080 --> 00:54:07,080 PITCH IDEAS AND DISCUSS WHAT THE 1267 00:54:07,080 --> 00:54:08,760 IDEAS MIGHT BE. 1268 00:54:08,760 --> 00:54:10,720 THEN THE PROGRAM MANAGER IS 1269 00:54:10,720 --> 00:54:15,320 GIVEN HE FUND -- THE FUNDING 1270 00:54:15,320 --> 00:54:17,200 AND REASONABLE FOR DELIVERING ON 1271 00:54:17,200 --> 00:54:23,120 ITS ACTIVITY. 1272 00:54:23,120 --> 00:54:28,800 GIVEN IT'S A BOTTOM-UP APPROACH 1273 00:54:28,800 --> 00:54:31,200 BUT THE DISCUSSIONS GIVE A GOOD 1274 00:54:31,200 --> 00:54:31,880 SENSE OF CONFIDENCE IT WILL BE 1275 00:54:31,880 --> 00:54:36,880 PRODUCTIVE. 1276 00:54:36,880 --> 00:54:39,000 >>I THOUGHT IT WOULD BE A GREAT 1277 00:54:39,000 --> 00:54:41,680 IDEA TO INVITE THEM OVER TO SEE 1278 00:54:41,680 --> 00:54:45,920 THE INTRAMURAL RESOURCES. 1279 00:54:45,920 --> 00:54:48,520 >>WE DID TOO. 1280 00:54:48,520 --> 00:54:49,280 SCIENTIFICALLY SPEAKING THEY 1281 00:54:49,280 --> 00:54:50,120 HAVE A LOT OF INTEREST IN THE 1282 00:54:50,120 --> 00:54:52,040 WORK WE'RE DOING AND LARGELY 1283 00:54:52,040 --> 00:54:52,960 EXPERTISE IN THE GENE THERAPY 1284 00:54:52,960 --> 00:54:53,520 SPACE TOO. 1285 00:54:53,520 --> 00:54:59,120 I'M EXCITED ABOUT SOME OF THOSE 1286 00:54:59,120 --> 00:55:09,280 IDEAS AND OF COURSE WITH NIH AND 1287 00:55:09,280 --> 00:55:09,640 THEM TOO. 1288 00:55:09,640 --> 00:55:12,520 IT WON'T BE THE FIRST TIME WE'LL 1289 00:55:12,520 --> 00:55:23,000 KEEP INVITING THEM BACK TOO. 1290 00:55:30,960 --> 00:55:31,760 SERGIO. 1291 00:55:31,760 --> 00:55:35,160 >>THANK YOU FOR THE OVERVIEW. 1292 00:55:35,160 --> 00:55:36,200 YOU PRESENTED A LOT OF 1293 00:55:36,200 --> 00:55:36,720 INFORMATION. 1294 00:55:36,720 --> 00:55:38,960 VERY HELPFUL SEE ALL THE THINGS 1295 00:55:38,960 --> 00:55:43,280 BEING DONE AT NCATS UNDER YOUR 1296 00:55:43,280 --> 00:55:53,520 LEADERSHIP. 1297 00:55:57,840 --> 00:56:01,160 AS YOU WORK ON THE STRATEGIC 1298 00:56:01,160 --> 00:56:02,760 PLAN YOUR EFFORTS TO HAVE 1299 00:56:02,760 --> 00:56:07,960 LISTENING SESSIONS ACROSS THE 1300 00:56:07,960 --> 00:56:10,040 NATION TO DO THE ROUNDTABLE 1301 00:56:10,040 --> 00:56:11,120 TAKES TIME AND ENERGY FROM YOU 1302 00:56:11,120 --> 00:56:11,920 AND YOUR TEAM. 1303 00:56:11,920 --> 00:56:13,040 YOU'RE DOING IT. 1304 00:56:13,040 --> 00:56:18,120 THOSE ARE FANTASTIC. 1305 00:56:18,120 --> 00:56:22,880 I PARTICIPATE D IN ONE. 1306 00:56:22,880 --> 00:56:24,720 THE OTHER THING YOU'RE DOING I 1307 00:56:24,720 --> 00:56:27,320 WANTED TO EMPHASIZE IS REACHING 1308 00:56:27,320 --> 00:56:29,160 OUT TO COMMUNITY, ADVISORY BOARD 1309 00:56:29,160 --> 00:56:34,400 MEMBERS OF CTSAs TO LISTEN FROM 1310 00:56:34,400 --> 00:56:36,960 THEM AS WELL. 1311 00:56:36,960 --> 00:56:39,120 THEY'RE IN GOOD POSITION TO GIVE 1312 00:56:39,120 --> 00:56:48,600 MEANINGFUL FEEDBACK. 1313 00:56:48,600 --> 00:56:51,480 AND A GREAT POSITION TO PROVIDE 1314 00:56:51,480 --> 00:56:55,880 INPUT THAT CAN BE HELPFUL FOR 1315 00:56:55,880 --> 00:57:01,200 THE STRATEGIC PLANNING AND ONE 1316 00:57:01,200 --> 00:57:02,600 LAST THING. 1317 00:57:02,600 --> 00:57:04,800 I HOPE YOU RECOVER. 1318 00:57:04,800 --> 00:57:05,840 I'M SO SORRY MY FIRST MEET I 1319 00:57:05,840 --> 00:57:11,000 MISSED YOU. 1320 00:57:11,000 --> 00:57:13,320 I WAS LOOKING FORWARD TO SEEING 1321 00:57:13,320 --> 00:57:13,720 YOU AGAIN. 1322 00:57:13,720 --> 00:57:15,120 PLEASE BE WELL. 1323 00:57:15,120 --> 00:57:25,680 >>THANK YOU, SURGE YO. 1324 00:57:25,680 --> 00:57:26,880 AND I APPRECIATE YOUR COMMENTS 1325 00:57:26,880 --> 00:57:30,240 RELATED TO THE ROUNDTABLE. 1326 00:57:30,240 --> 00:57:32,800 WHEN WE EMBARKED ON THE 1327 00:57:32,800 --> 00:57:33,720 STRATEGIC PLANNING PROCESS I 1328 00:57:33,720 --> 00:57:36,200 WASN'T SURE HOW TO PROCEED BUT 1329 00:57:36,200 --> 00:57:38,320 IT MADE A LOT OF SENSE TO ME AND 1330 00:57:38,320 --> 00:57:41,160 TO OUR TEAM AND THEY EMBRACED IT 1331 00:57:41,160 --> 00:57:43,120 AS WELL. 1332 00:57:43,120 --> 00:57:44,720 CREDIT TO THEM BECAUSE IT'S 1333 00:57:44,720 --> 00:57:46,600 QUITE TIME CONSUMING. 1334 00:57:46,600 --> 00:57:50,440 I DID -- WE HAVE DONE 30 1335 00:57:50,440 --> 00:57:51,120 ROUNDTABLES SO FAR. 1336 00:57:51,120 --> 00:58:00,760 I'VE LOST MY VOICE. 1337 00:58:00,760 --> 00:58:02,080 IT HAS BEEN HELPFUL MEET THE 1338 00:58:02,080 --> 00:58:03,240 COMMUNITY AND STAKEHOLDERS. 1339 00:58:03,240 --> 00:58:05,440 WE HAVE NOT MET WILLING THE 1340 00:58:05,440 --> 00:58:06,520 COMMUNITY ADVISORY BOARD YET. 1341 00:58:06,520 --> 00:58:08,680 WE HAVE TWO MEETINGS COMING UP 1342 00:58:08,680 --> 00:58:09,920 LATER IN JUNE. 1343 00:58:09,920 --> 00:58:12,640 BUT THOSE ARE SCHEDULED AND I'M 1344 00:58:12,640 --> 00:58:13,600 LOOKING FORWARD TO THOSE. 1345 00:58:13,600 --> 00:58:17,320 WE HAD A COUPLE PUBLIC 1346 00:58:17,320 --> 00:58:19,120 ROUNDTABLES AS WELL AND ANOTHER 1347 00:58:19,120 --> 00:58:21,600 GROUP AND I REALLY APPRECIATE 1348 00:58:21,600 --> 00:58:22,840 THE COMMUNITY ADVISORY BOARD. 1349 00:58:22,840 --> 00:58:27,080 THE OTHER GROUP IS THE PATIENT 1350 00:58:27,080 --> 00:58:28,800 ADVISORY GROUPS PART OF THE RARE 1351 00:58:28,800 --> 00:58:30,320 DISEASE CLINICAL RESEARCH 1352 00:58:30,320 --> 00:58:30,880 NETWORK. 1353 00:58:30,880 --> 00:58:35,600 HEARING FROM THE PATIENT 1354 00:58:35,600 --> 00:58:37,920 ADVISORY GROUPS AND ADVISORY 1355 00:58:37,920 --> 00:58:42,720 GROUPS HAS BEEN HELPFUL AND 1356 00:58:42,720 --> 00:58:43,520 THERE ARE A LOT OF THEM AND HOW 1357 00:58:43,520 --> 00:58:46,400 YOU CAN LISTEN TO VOICES IN A 1358 00:58:46,400 --> 00:58:47,800 FORMAT LIKE THIS IS -- I WANTED 1359 00:58:47,800 --> 00:58:49,960 TO TRY TO MAKE IT AS ENGAGING AS 1360 00:58:49,960 --> 00:58:52,800 POSSIBLE AND ASK QUESTIONS IN 1361 00:58:52,800 --> 00:58:53,800 WAYS WE CAN GET WHAT'S IMPORTANT 1362 00:58:53,800 --> 00:58:58,760 TO THEM AND HELP US TO 1363 00:58:58,760 --> 00:58:59,840 PRIORITIZE THAT INPUT. 1364 00:58:59,840 --> 00:59:00,880 I THANK YOU FOR COMMENTING ON 1365 00:59:00,880 --> 00:59:03,600 THAT AND I LOOK FORWARD TO MORE 1366 00:59:03,600 --> 00:59:04,000 TO COME. 1367 00:59:04,000 --> 00:59:05,600 I ALSO THINK IT'S REALLY 1368 00:59:05,600 --> 00:59:07,080 IMPORTANT THIS ISN'T JUST 1369 00:59:07,080 --> 00:59:08,600 BECAUSE WE'RE DOING THE 1370 00:59:08,600 --> 00:59:09,360 STRATEGIC PLAN PROCESS BUT 1371 00:59:09,360 --> 00:59:09,880 SOMETHING THAT WE NEED TO 1372 00:59:09,880 --> 00:59:15,440 CONTINUE TO DO. 1373 00:59:15,440 --> 00:59:17,160 WE PUT PATIENTS AND COMMUNITIES 1374 00:59:17,160 --> 00:59:18,360 FRONT AND CENTER IN THE WORK WE 1375 00:59:18,360 --> 00:59:20,160 DO AND I THINK THAT'S GOING TO 1376 00:59:20,160 --> 00:59:21,800 BE IMPORTANT TO CONTINUE AS 1377 00:59:21,800 --> 00:59:22,040 WELL. 1378 00:59:22,040 --> 00:59:24,440 THAT'S GOING TO MAKE THIS A 1379 00:59:24,440 --> 00:59:26,440 SUCCESS NO MATTER WHAT HAPPENS 1380 00:59:26,440 --> 00:59:27,520 IN TERMS OF MEETING OUR ACTUAL 1381 00:59:27,520 --> 00:59:28,520 GOALS BUT I THINK THAT'S GOING 1382 00:59:28,520 --> 00:59:29,800 TO MAKE IT A SUCCESS. 1383 00:59:29,800 --> 00:59:36,440 I APPRECIATE THE INPUT. 1384 00:59:36,440 --> 00:59:37,640 PAULA, PLEASE, NICE TO SEE YOU. 1385 00:59:37,640 --> 00:59:39,680 >>NICE TO SEE YOU, JONI. 1386 00:59:39,680 --> 00:59:41,760 YOU PRESENTED A LOT OF AMAZING 1387 00:59:41,760 --> 00:59:43,560 PROJECTS NCATS WAS DOING. 1388 00:59:43,560 --> 00:59:45,520 I WAS PARTICULARLY STRUCK BY 1389 00:59:45,520 --> 00:59:47,680 SOME OF THE PIPELINE OR PATHWAY 1390 00:59:47,680 --> 00:59:49,680 PROGRAMS GOING INTO THE K-5. 1391 00:59:49,680 --> 00:59:54,560 WHEN YOU LOOK AT TRYING TO GET 1392 00:59:54,560 --> 00:59:57,400 RURAL KIDS IN UNDER SERVED 1393 00:59:57,400 --> 00:59:58,520 POPULATIONS AND DISADVANTAGED 1394 00:59:58,520 --> 01:00:02,800 POPULATIONS INTO SCIENCE OR 1395 01:00:02,800 --> 01:00:04,240 MEDICINE OR HEALTH CARE, THEY 1396 01:00:04,240 --> 01:00:07,800 FALL BEHIND IN MATH AND SCIENCE 1397 01:00:07,800 --> 01:00:08,680 AND THEN IT DOESN'T MATTER IF 1398 01:00:08,680 --> 01:00:10,640 YOU HIT THEM IN HIGH SCHOOL 1399 01:00:10,640 --> 01:00:11,760 THEY'RE ALREADY TOO FAR BEHIND. 1400 01:00:11,760 --> 01:00:15,800 I'M WONDERING IF YOU CAN SHARE 1401 01:00:15,800 --> 01:00:20,680 SOME OF THE THINGS NOT HERE BUT 1402 01:00:20,680 --> 01:00:25,280 WE HAVE A LOT OF RURAL PROGRAMS 1403 01:00:25,280 --> 01:00:27,120 AT TEXAS A&M AND IT SEEMS LIKE 1404 01:00:27,120 --> 01:00:29,480 THE ROLE PLAYS FOR THE K-5 WOULD 1405 01:00:29,480 --> 01:00:31,000 FIT IN WELL WITH WHAT WE'RE 1406 01:00:31,000 --> 01:00:33,200 TRYING TO DO AND I'M SURE WHAT 1407 01:00:33,200 --> 01:00:33,880 OTHERS ACROSS THE COUNTRY ARE 1408 01:00:33,880 --> 01:00:35,600 TRYING TO DO. 1409 01:00:35,600 --> 01:00:37,080 >>YEAH, THANK YOU FOR THAT 1410 01:00:37,080 --> 01:00:37,520 COMMENT. 1411 01:00:37,520 --> 01:00:47,880 THAT'S A GREAT IDEA. 1412 01:00:49,840 --> 01:00:52,200 MAYBE IT COULD BE ENCOURAGING 1413 01:00:52,200 --> 01:00:58,360 FOR CTSA PROGRAMS AND ENGAGEMENT 1414 01:00:58,360 --> 01:01:04,800 IN OUTREACH AND THAT WOULD BE 1415 01:01:04,800 --> 01:01:05,120 TERRIFIC. 1416 01:01:05,120 --> 01:01:06,400 I'D LOVE TO TALK TO YOU MORE 1417 01:01:06,400 --> 01:01:07,480 ABOUT SOME OF THOSE IDEAS. 1418 01:01:07,480 --> 01:01:10,240 WE'RE HAPPY TO SHARE AND FOLLOW 1419 01:01:10,240 --> 01:01:11,080 UP DIRECTLY ON THAT AND PERHAPS 1420 01:01:11,080 --> 01:01:14,840 GIVE YOU SOME OF THE WORK WE'VE 1421 01:01:14,840 --> 01:01:16,880 BEEN DOING. 1422 01:01:16,880 --> 01:01:17,960 ANNA IS TELLING ME WE'RE A 1423 01:01:17,960 --> 01:01:19,880 LITTLE BIT OVER TIME SO I'M 1424 01:01:19,880 --> 01:01:24,440 GOING TO JUST MOVE US ALONG HERE 1425 01:01:24,440 --> 01:01:25,720 AND REMINDED WE HAVE A BIT OF 1426 01:01:25,720 --> 01:01:27,520 TIME AT THE END OF THE DAY IN 1427 01:01:27,520 --> 01:01:29,320 ADDITION TO THE OTHER 1428 01:01:29,320 --> 01:01:30,360 CONVERSATIONS AND DISCUSSIONS 1429 01:01:30,360 --> 01:01:31,840 WE'LL HAVE THROUGHOUT THE 1430 01:01:31,840 --> 01:01:33,160 REMAINDER OF THE AGENDA BUT BUT 1431 01:01:33,160 --> 01:01:38,800 I THINK WE CAN GO AHEAD AND MOVE 1432 01:01:38,800 --> 01:01:41,800 ALO 1433 01:01:41,800 --> 01:01:42,000 ALONG. 1434 01:01:42,000 --> 01:01:43,000 WE'RE GOING IN THE NEXT SESSION 1435 01:01:43,000 --> 01:01:44,320 ON THE STRATEGIC PLAN 1436 01:01:44,320 --> 01:01:45,240 DISCUSSION. 1437 01:01:45,240 --> 01:01:47,760 I'D LIKE TO DEUCE MEREDITH 1438 01:01:47,760 --> 01:01:55,880 TEMPLE O'CONNOR AND PEN YNY 1439 01:01:55,880 --> 01:01:56,160 BERGUNE. 1440 01:01:56,160 --> 01:01:59,120 PENNY IS THE DIRECTOR OF THE 1441 01:01:59,120 --> 01:02:01,920 OFFICE AND MEREDITH IS THE 1442 01:02:01,920 --> 01:02:04,760 SCIENCE POLICY DIRECTOR AS WELL 1443 01:02:04,760 --> 01:02:09,880 AND THEY'RE USHER THE NEXT 1444 01:02:09,880 --> 01:02:14,320 SESSION. 1445 01:02:14,320 --> 01:02:15,160 >>THANK YOU, EVERYBODY. 1446 01:02:15,160 --> 01:02:19,680 I'M HAPPY TO GIVE THE COUNCIL 1447 01:02:19,680 --> 01:02:23,680 ALONG WITH DR. O'CONNOR WHERE WE 1448 01:02:23,680 --> 01:02:25,880 ARE IN THE NCATS 2024 STRATEGIC 1449 01:02:25,880 --> 01:02:29,200 PLANNING PROCESS. 1450 01:02:29,200 --> 01:02:30,120 OUR CURRENT NCATS STRATEGIC PLAN 1451 01:02:30,120 --> 01:02:32,720 IS DATED FALL OF 2016. 1452 01:02:32,720 --> 01:02:38,840 IT'S WELL OVERDUE TO DO A DEEP 1453 01:02:38,840 --> 01:02:40,800 DIVE INTO ENGAGING OUR 1454 01:02:40,800 --> 01:02:41,960 COMMUNITIES WHAT WE SHOULD BE 1455 01:02:41,960 --> 01:02:44,320 THINKING ABOUT AND THE GAPS AND 1456 01:02:44,320 --> 01:02:45,080 OPPORTUNITIES TO ADDRESS. 1457 01:02:45,080 --> 01:02:49,320 WITH THAT I'M GOING TO HAVE 1458 01:02:49,320 --> 01:02:50,000 MEREDITH LEAD THE PRESENTATION 1459 01:02:50,000 --> 01:02:52,160 AND I'LL PICK UP ON THE BACK 1460 01:02:52,160 --> 01:02:52,760 END. 1461 01:02:52,760 --> 01:02:54,000 GO AHEAD, MEREDITH. 1462 01:02:54,000 --> 01:02:55,000 >>THANK YOU SO MUCH. 1463 01:02:55,000 --> 01:02:55,800 CAN YOU ALL HEAR ME OKAY? 1464 01:02:55,800 --> 01:03:02,480 GREAT. 1465 01:03:02,480 --> 01:03:04,280 WE'RE THINKING ABOUT A ROAD MAP 1466 01:03:04,280 --> 01:03:08,960 FOR THE DECADE AHEAD. 1467 01:03:08,960 --> 01:03:09,440 . 1468 01:03:09,440 --> 01:03:11,040 TYPICALLY STRATEGIC PLANS ARE 1469 01:03:11,040 --> 01:03:11,960 ABOUT FIVE YEARS. 1470 01:03:11,960 --> 01:03:14,240 OURS IS A LITTLE BIT OLDER AND 1471 01:03:14,240 --> 01:03:15,760 THERE'S REASONS FOR THAT I'LL 1472 01:03:15,760 --> 01:03:18,240 DIVE INTO IN A SECOND BUT WE'RE 1473 01:03:18,240 --> 01:03:19,120 DELIGHTED TO HAVE KICKED THIS 1474 01:03:19,120 --> 01:03:22,880 OFF AND BE ENGAGING ACROSS THE 1475 01:03:22,880 --> 01:03:24,920 BOARD WITH DIFFERENT 1476 01:03:24,920 --> 01:03:29,240 STAKEHOLDERS AND IN DIFFERENT 1477 01:03:29,240 --> 01:03:31,600 WAYS AND FORMATS FOR THIS 1478 01:03:31,600 --> 01:03:31,840 PROCESS. 1479 01:03:31,840 --> 01:03:34,800 AS DR. RUTTER TALKED ABOUT A LOT 1480 01:03:34,800 --> 01:03:37,720 AND IN INTERNAL ENGAGEMENT 1481 01:03:37,720 --> 01:03:39,320 SESSIONS AND JONI, DON'T MEAN TO 1482 01:03:39,320 --> 01:03:40,920 SPEAK FOR YOU SO FEEL FREE TO 1483 01:03:40,920 --> 01:03:42,520 CHIME IN BUT IT'S ABOUT 1484 01:03:42,520 --> 01:03:43,560 CO-DESIGNING A STRATEGIC PLAN. 1485 01:03:43,560 --> 01:03:45,720 THIS IS SOMETHING WHERE WE DO 1486 01:03:45,720 --> 01:03:49,920 VERY MUCH VALUE THE INPUT FROM 1487 01:03:49,920 --> 01:03:50,960 OUR DIFFERENT STAKEHOLDERS AND 1488 01:03:50,960 --> 01:03:53,840 WANT TO THINK OF THIS AS AN 1489 01:03:53,840 --> 01:03:57,000 ACTIONABLE ROAD MAP TO ACHIEVING 1490 01:03:57,000 --> 01:04:00,440 THEACIOUS -- 1491 01:04:04,360 --> 01:04:09,640 THE AUDACIOUS GOALS. 1492 01:04:09,640 --> 01:04:18,160 THE TIME LINE WE STARTED TO GET 1493 01:04:18,160 --> 01:04:19,880 ORGANIZED AS SOON AS SHE WAS 1494 01:04:19,880 --> 01:04:21,440 NAMED DIRECTOR AND WE START THE 1495 01:04:21,440 --> 01:04:23,120 STRATEGIC PLAN BUT WHEN 1496 01:04:23,120 --> 01:04:24,800 DR. AUSTIN ANNOUNCED HIS 1497 01:04:24,800 --> 01:04:28,000 DEPARTURE DR. RUTTER DECIDED IT 1498 01:04:28,000 --> 01:04:30,280 WAS BEST TO WAIT UNTIL A 1499 01:04:30,280 --> 01:04:31,120 PERMANENT DIRECTOR WAS NAMED AND 1500 01:04:31,120 --> 01:04:33,720 AS SOON AS SHE WAS NAMED WE 1501 01:04:33,720 --> 01:04:35,600 STARTED MOVING FORWARD AGAIN ON 1502 01:04:35,600 --> 01:04:36,240 THE PLAN. 1503 01:04:36,240 --> 01:04:37,440 THIS HOPEFULLY GIVES A SENSE OF 1504 01:04:37,440 --> 01:04:38,520 THE TIME LINE WE'RE WORKING WITH 1505 01:04:38,520 --> 01:04:41,040 AND SOME OF THE ACTIVITIES WE'RE 1506 01:04:41,040 --> 01:04:42,680 UNDERTAKING AS PART OF THE 1507 01:04:42,680 --> 01:04:43,720 STRATEGIC PLANNING PROCESS. 1508 01:04:43,720 --> 01:04:46,320 WE ARE HOPING AND TARGETING FOR 1509 01:04:46,320 --> 01:04:51,400 A ROLLOUT IN EARLY 2024 BUT WE 1510 01:04:51,400 --> 01:04:57,840 ALSO JUST NOW WITH THE PUBLIC 1511 01:04:57,840 --> 01:05:00,400 ROUND MEETINGS WE'RE WRESTLING 1512 01:05:00,400 --> 01:05:01,920 WITH DATA WE WANT TO CAREFULLY 1513 01:05:01,920 --> 01:05:04,360 AND DELIBERATELY WORK THROUGH. 1514 01:05:04,360 --> 01:05:06,720 THIS THE TARGET DATE BUT DON'T 1515 01:05:06,720 --> 01:05:08,840 HOLD ME TOO IT IF IT TAKES 1516 01:05:08,840 --> 01:05:10,600 LONGER TO GET THROUGH THINGS. 1517 01:05:10,600 --> 01:05:12,040 WE WANT TO BE THOUGHTFUL ABOUT 1518 01:05:12,040 --> 01:05:13,360 THE INPUT WE'RE GETTING AND HOW 1519 01:05:13,360 --> 01:05:16,480 IT SHAPES OUR STRATEGIC PLAN. 1520 01:05:16,480 --> 01:05:19,040 WE'RE VERY MUCH IN THE INITIAL 1521 01:05:19,040 --> 01:05:19,920 STAKEHOLDER ENGAGEMENT PART AS 1522 01:05:19,920 --> 01:05:22,560 DR. RUTTER TALKED ABOUT AND HAD 1523 01:05:22,560 --> 01:05:24,080 ROUNDTABLE INTERNALLY AND 1524 01:05:24,080 --> 01:05:24,360 EXTERNALLY. 1525 01:05:24,360 --> 01:05:25,640 SHE LAID OUT A PRESENTATION WITH 1526 01:05:25,640 --> 01:05:29,880 HER VISION AND AUDACIOUS GOALS 1527 01:05:29,880 --> 01:05:33,640 AND WE WALKED THROUGH A SET OF 1528 01:05:33,640 --> 01:05:33,920 QUESTIONS. 1529 01:05:33,920 --> 01:05:36,720 WE'LL CONTINUE WITH A MORE 1530 01:05:36,720 --> 01:05:37,920 OPEN-ENDED DISCUSSION WITH THE 1531 01:05:37,920 --> 01:05:47,080 ADVISORY COUNCIL AND DR. RUTTER 1532 01:05:47,080 --> 01:05:49,600 AND TWO OTHERS. 1533 01:05:49,600 --> 01:05:51,960 AFTER WE START TO SYNTHESIZE THE 1534 01:05:51,960 --> 01:05:53,720 FEEDBACK WE'RE PLANNING TO PUT 1535 01:05:53,720 --> 01:05:54,680 OUT REQUEST FOR INFORMATION. 1536 01:05:54,680 --> 01:05:56,800 ONE FOR THE PUBLIC AS 1537 01:05:56,800 --> 01:05:57,600 STAKEHOLDERS ON THE PUBLIC SIDE 1538 01:05:57,600 --> 01:06:05,840 AS WELL AS FOR OUR STAFF. 1539 01:06:05,840 --> 01:06:07,920 WE'D LIKE TO DIGEST THE INPUT 1540 01:06:07,920 --> 01:06:11,080 RECEIVED BEFORE WE START TO 1541 01:06:11,080 --> 01:06:16,320 SHAPE THAT. 1542 01:06:16,320 --> 01:06:18,520 THE OTHER THING IS WE WANT THIS 1543 01:06:18,520 --> 01:06:20,680 TO BE ROBUST ALIGNING WITH OUR 1544 01:06:20,680 --> 01:06:22,880 MISSION AND VISION ECHOING OUR 1545 01:06:22,880 --> 01:06:23,920 VALUES AND SHARED VALUES WITH 1546 01:06:23,920 --> 01:06:24,480 OUR COMMUNITY. 1547 01:06:24,480 --> 01:06:31,120 AS MENTIONED AND SHE'S MENTION 1548 01:06:31,120 --> 01:06:39,120 ED AND WHILE HER GOALS ARE 1549 01:06:39,120 --> 01:06:41,640 THOUGHT TO BE INSPIRATIONAL AND 1550 01:06:41,640 --> 01:06:44,560 WE WANT TO MAKE SURE IN THE 1551 01:06:44,560 --> 01:06:45,680 INTERVENING YEARS THE 1552 01:06:45,680 --> 01:06:48,400 ACTIVITIES, GOALS, OBJECTIVES WE 1553 01:06:48,400 --> 01:06:50,640 LAY OUT ARE OBTAINABLE AND 1554 01:06:50,640 --> 01:06:50,920 MEASURABLE. 1555 01:06:50,920 --> 01:06:52,560 SOMETHING ELSE I'LL SHARE IS A 1556 01:06:52,560 --> 01:06:53,360 CONVERSATION DR. RUTTER AND 1557 01:06:53,360 --> 01:06:54,760 OTHERS INTERNALLY HAVE HAD IS 1558 01:06:54,760 --> 01:06:56,920 THIS IS NOT SOMETHING WE WANT TO 1559 01:06:56,920 --> 01:07:01,320 PUT ON THE SHELF FOR FIVE YEARS. 1560 01:07:01,320 --> 01:07:04,680 THEN SAY HOW DID WE DO? 1561 01:07:04,680 --> 01:07:06,880 THIS IS SOMETHING WE WANT TO 1562 01:07:06,880 --> 01:07:08,040 THINK ABOUT MAYBE NOT QUITE REAL 1563 01:07:08,040 --> 01:07:12,720 TIME BUT CLOSER TO THAT. 1564 01:07:12,720 --> 01:07:14,640 CHECKING IN WITH OURSELVES AND 1565 01:07:14,640 --> 01:07:16,000 STAKEHOLDERS AFTER THE PLAN IS 1566 01:07:16,000 --> 01:07:18,120 RELEASED TO TAKE WITH OURSELVES 1567 01:07:18,120 --> 01:07:19,040 WHERE WE ARE. 1568 01:07:19,040 --> 01:07:24,520 WE'RE AN AGILE ORGANIZATION THAT 1569 01:07:24,520 --> 01:07:26,080 MOVES TOWARDS OPPORTUNITIES AND 1570 01:07:26,080 --> 01:07:28,680 IT'S A BIG ROBUST SPACE AND WE 1571 01:07:28,680 --> 01:07:33,520 WANT TO MAKE SURE OUR PLAN IS IN 1572 01:07:33,520 --> 01:07:35,560 THAT FRAME AS WELL. 1573 01:07:35,560 --> 01:07:37,560 IT'S ALSO A POWERFUL TOOL TO BE 1574 01:07:37,560 --> 01:07:39,040 SUCCESSFUL AND CHECKING IN WITH 1575 01:07:39,040 --> 01:07:40,520 OURSELVES ON A ROUTINE BASIS. 1576 01:07:40,520 --> 01:07:43,000 AS DR. RUTTER LIKES TO TALK 1577 01:07:43,000 --> 01:07:45,000 ABOUT A LOT WE'RE OKAY AND 1578 01:07:45,000 --> 01:07:48,400 COMFORTABLE WITH RISK AND 1579 01:07:48,400 --> 01:07:49,640 FAILURE BUT WANT TO FAIL FORWARD 1580 01:07:49,640 --> 01:07:50,400 AND LEARN AND MOVE FORWARD FROM 1581 01:07:50,400 --> 01:07:56,040 IT. 1582 01:07:56,040 --> 01:07:57,800 THIS SHOULD BE FAMILIAR TO MOST 1583 01:07:57,800 --> 01:07:58,840 STAKEHOLDERS AND THE PUBLIC 1584 01:07:58,840 --> 01:08:00,320 JOINING ON THE VIDEOCAST AND THE 1585 01:08:00,320 --> 01:08:02,560 ADVISORY COUNCIL, THIS IS 1586 01:08:02,560 --> 01:08:03,960 DR. RUTTER'S VISION OF MORE 1587 01:08:03,960 --> 01:08:07,120 TREATMENTS FOR ALL PEOPLE MORE 1588 01:08:07,120 --> 01:08:15,520 QUICKLY. 1589 01:08:15,520 --> 01:08:21,240 AND THIS WILL LIKELY INFORM THE 1590 01:08:21,240 --> 01:08:22,840 STRATEGIC PLAN. 1591 01:08:22,840 --> 01:08:25,000 THESE ARE THE THREE AUDICIOUS 1592 01:08:25,000 --> 01:08:26,440 GOALS IN CASE YOU HAVEN'T HAD AN 1593 01:08:26,440 --> 01:08:28,520 TONIGHT TO HAVE HEARD ABOUT 1594 01:08:28,520 --> 01:08:28,960 THEM. 1595 01:08:28,960 --> 01:08:30,880 BY THE WAY, I'LL ALSO MAKE A 1596 01:08:30,880 --> 01:08:34,040 SMALL SIDE NOTE WE'LL BE POSTING 1597 01:08:34,040 --> 01:08:35,040 THE PUBLIC ROUNDTABLE RECORDING 1598 01:08:35,040 --> 01:08:41,280 DR. RUTTER PRESENTED AT 1599 01:08:41,280 --> 01:08:42,040 PUBLICLY. 1600 01:08:42,040 --> 01:08:46,360 IF FOLKS HAVEN'T HAD THE 1601 01:08:46,360 --> 01:08:49,120 OPPORTUNITY TO HEAR THESE PIECES 1602 01:08:49,120 --> 01:08:54,560 WE'LLING POSTING THAT AND WE'LL 1603 01:08:54,560 --> 01:08:57,000 HAVE A MAILBOX THEY ARE 1604 01:08:57,000 --> 01:08:57,720 AUDACIOUS. 1605 01:08:57,720 --> 01:09:00,640 IT'S EXCITING TIME TO BE WORKING 1606 01:09:00,640 --> 01:09:02,520 AT NCATS AND SEE US TRY TO 1607 01:09:02,520 --> 01:09:04,360 HARNESS THE POTENTIAL THAT IS 1608 01:09:04,360 --> 01:09:09,800 THERE IN THE TRANSLATIONAL 1609 01:09:09,800 --> 01:09:10,800 SCIENCE SPACE. 1610 01:09:10,800 --> 01:09:12,600 THEY'RE QUITE ASPIRATIONAL AND 1611 01:09:12,600 --> 01:09:14,120 SOMETHING WE WANT TO BUILD TO. 1612 01:09:14,120 --> 01:09:15,520 I WILL SAY THEY'RE NOT THE SAME 1613 01:09:15,520 --> 01:09:19,120 AS THE GOALS OF THE STRATEGIC 1614 01:09:19,120 --> 01:09:20,440 PLAN. 1615 01:09:20,440 --> 01:09:22,480 WE HAVE NOT PUT PEN TO PAPER ON 1616 01:09:22,480 --> 01:09:25,720 THE STRATEGIC PLAN BECAUSE THE 1617 01:09:25,720 --> 01:09:26,960 INPUT PIECE IS IMPORTANT TO OUR 1618 01:09:26,960 --> 01:09:30,240 WORK TO MAKE SURE WE GET THAT 1619 01:09:30,240 --> 01:09:31,400 AND HAVE AN OPPORTUNITY TO 1620 01:09:31,400 --> 01:09:32,640 DIGEST IT BEFORE WE START TO 1621 01:09:32,640 --> 01:09:33,400 WRITE THE PLAN. 1622 01:09:33,400 --> 01:09:34,640 I WANT TO BE CLEAR BECAUSE IT'S 1623 01:09:34,640 --> 01:09:39,920 BEEN CONFUSING FOR FOLKS AT 1624 01:09:39,920 --> 01:09:40,480 TIMES DURING DURING SOME 1625 01:09:40,480 --> 01:09:42,560 FEEDBACK SESSIONS TO MAKE SURE 1626 01:09:42,560 --> 01:09:44,280 IT'S CLEAR THESE ARE NOT THE 1627 01:09:44,280 --> 01:09:49,720 SAME AS WHAT WE'LL PUT TOGETHER 1628 01:09:49,720 --> 01:09:57,800 FOR THE STRATEGIC PLAN. 1629 01:09:57,800 --> 01:10:01,400 WILL SET HOW WE'RE THINKING 1630 01:10:01,400 --> 01:10:03,360 ABOUT THE STRATEGIC PLAN. 1631 01:10:03,360 --> 01:10:07,160 THE ALL TREATMENTS FOR ALL 1632 01:10:07,160 --> 01:10:12,440 PEOPLE IS MORE FEEDBACK AND THE 1633 01:10:12,440 --> 01:10:12,880 MEETINGS AS WELL. 1634 01:10:12,880 --> 01:10:14,680 IT'S NOT ALL WE DO AND THINK 1635 01:10:14,680 --> 01:10:14,960 ABOUT. 1636 01:10:14,960 --> 01:10:16,640 THESE ARE OBVIOUSLY SUPER 1637 01:10:16,640 --> 01:10:17,880 IMPORTANT ASPECTS OF WHO WE ARE 1638 01:10:17,880 --> 01:10:23,720 AS A CENTER AND WHAT WE THINK 1639 01:10:23,720 --> 01:10:27,080 ABOUT. 1640 01:10:27,080 --> 01:10:30,520 WE HAVE OTHER AREAS ON OUR RADAR 1641 01:10:30,520 --> 01:10:31,240 FOR STRATEGIC PLANNING. 1642 01:10:31,240 --> 01:10:33,760 I HAD THE OPPORTUNITY TO BE PART 1643 01:10:33,760 --> 01:10:38,800 OF THE NIH STRATEGIC PLAN AND 1644 01:10:38,800 --> 01:10:41,000 THEY TALKED ABOUT CROSS-CUTTING 1645 01:10:41,000 --> 01:10:41,240 THEMES. 1646 01:10:41,240 --> 01:10:44,560 WE'VE TALKED ABOUT THESE IDEAS 1647 01:10:44,560 --> 01:10:48,840 IN SOME SOMEWHAT THEY DON'T KNOW 1648 01:10:48,840 --> 01:10:51,040 QUITE YET HOW WE'LL SHAPE THEM 1649 01:10:51,040 --> 01:10:52,680 UP AND FIGURE THEM INTO THE 1650 01:10:52,680 --> 01:10:54,320 STRATEGIC PLAN BUT THAT'S ONE 1651 01:10:54,320 --> 01:10:55,360 WAY WE'RE THINKING ABOUT THEM. 1652 01:10:55,360 --> 01:10:58,160 COULD THEY BE CROSS-CUTTING 1653 01:10:58,160 --> 01:10:59,600 THEMES OR SPECIFIC TOPIC AREAS 1654 01:10:59,600 --> 01:11:01,160 WITHIN OUR GOALS AND OBJECTIVES 1655 01:11:01,160 --> 01:11:02,480 BUT I JUST WANTED TO MAKE SURE 1656 01:11:02,480 --> 01:11:03,760 FOLKS ARE CLEAR THAT IN ADDITION 1657 01:11:03,760 --> 01:11:05,920 TO THE MORE TREATMENTS FOR ALL 1658 01:11:05,920 --> 01:11:07,920 PEOPLE, MORE QUICKLY AND THE 1659 01:11:07,920 --> 01:11:10,680 AUDACIOUS GOALS WE'RE THINKING 1660 01:11:10,680 --> 01:11:13,440 ABOUT OTHER PIECES AND HOW THEY 1661 01:11:13,440 --> 01:11:16,080 FIT INTO THE BROADER CONTEXT AND 1662 01:11:16,080 --> 01:11:16,800 FRAMING OF WHO WE ARE. 1663 01:11:16,800 --> 01:11:18,880 THE ONE THING I'LL MENTIONED. 1664 01:11:18,880 --> 01:11:21,440 MOST WOULD BE VERY FAMILIAR TO 1665 01:11:21,440 --> 01:11:22,760 OUR STAKEHOLDERS AND ADVISORY 1666 01:11:22,760 --> 01:11:23,080 COUNCIL. 1667 01:11:23,080 --> 01:11:25,240 THERE'S A LOT OF THINGS WE 1668 01:11:25,240 --> 01:11:27,120 ALREADY DO ON A REGULAR BASIS 1669 01:11:27,120 --> 01:11:29,160 BUT JUST WANT TO MAKE SURE FOLKS 1670 01:11:29,160 --> 01:11:33,440 REALIZE WE'RE THINKING ABOUT 1671 01:11:33,440 --> 01:11:34,000 THESE AS WELL. 1672 01:11:34,000 --> 01:11:36,560 STEWARDSHIP IS ONE OF THE 1673 01:11:36,560 --> 01:11:37,680 REQUIREMENTS IN THE NIH CENTERED 1674 01:11:37,680 --> 01:11:38,880 STRATEGIC PLAN. 1675 01:11:38,880 --> 01:11:40,880 THE REST ARE OUR THINKING ABOUT 1676 01:11:40,880 --> 01:11:43,080 DIFFERENT AREAS WE WANT TO HAVE 1677 01:11:43,080 --> 01:11:48,280 ON THE RADAR FOR OUR STRATEGIC 1678 01:11:48,280 --> 01:11:48,920 PLAN. 1679 01:11:48,920 --> 01:11:52,400 THIS IS WHERE I'M GOING HAND OFF 1680 01:11:52,400 --> 01:11:54,240 TO DR. BERGOON IN THE ROOM. 1681 01:11:54,240 --> 01:11:56,200 I TO BE THERE IN PERSON BUT 1682 01:11:56,200 --> 01:11:59,520 SHE'S GOING TO WALK YOU THROUGH 1683 01:11:59,520 --> 01:12:00,920 SOME ACTIVITIES. 1684 01:12:00,920 --> 01:12:02,880 OBVIOUSLY YOU ALREADY SAW THIS 1685 01:12:02,880 --> 01:12:04,120 IN THE WEALTH OF WAYS WE'RE 1686 01:12:04,120 --> 01:12:05,680 TRYING TO ENGAGE WITH 1687 01:12:05,680 --> 01:12:06,160 STAKEHOLDERS. 1688 01:12:06,160 --> 01:12:07,920 SHE'S GOING TO WALK YOU THROUGH 1689 01:12:07,920 --> 01:12:10,480 SOME OF THE WORK WITH THE PUBLIC 1690 01:12:10,480 --> 01:12:11,680 ROUND TABLES AND INITIAL 1691 01:12:11,680 --> 01:12:13,680 FEEDBACK AND WE'LL WORK WITH 1692 01:12:13,680 --> 01:12:15,600 DR. RUTTER TO OPEN IT UP FOR A 1693 01:12:15,600 --> 01:12:16,680 COUNCIL DISCUSSION AND I LOOK 1694 01:12:16,680 --> 01:12:19,120 FORWARD TO BEING PART OF THAT AS 1695 01:12:19,120 --> 01:12:26,680 WELL. 1696 01:12:26,680 --> 01:12:29,360 >>THANK YOU. 1697 01:12:29,360 --> 01:12:31,600 WE GATHERED INPUT FROM MANY 1698 01:12:31,600 --> 01:12:36,160 STAKEHOLDERS BOTH INTERNALLY AND 1699 01:12:36,160 --> 01:12:37,920 EXTERNALLY ABOUT WHERE WE SHOULD 1700 01:12:37,920 --> 01:12:41,440 GO AND THINK ABOUT IN OUR NEXT 1701 01:12:41,440 --> 01:12:43,080 STRATEGIC PLAN. 1702 01:12:43,080 --> 01:12:48,200 THIS IS COLOR CODED. 1703 01:12:48,200 --> 01:12:51,040 AND THEY HAVE WORKED WITH THE 1704 01:12:51,040 --> 01:12:52,160 CLINICAL AND TRANSLATIONAL 1705 01:12:52,160 --> 01:12:55,240 SCIENCE PROGRAMS P.I.s AND THEIR 1706 01:12:55,240 --> 01:12:57,240 STAFF ABOUT DIFFERENT WAYS THEY 1707 01:12:57,240 --> 01:13:00,040 CAN ENGAGE AN PROVIDE INPUT IN 1708 01:13:00,040 --> 01:13:00,520 THE PLANNING EFFORT. 1709 01:13:00,520 --> 01:13:03,080 ALSO ENGAGED WITH THE RARE 1710 01:13:03,080 --> 01:13:04,600 DISEASES COMMUNITY TALKING TO 1711 01:13:04,600 --> 01:13:13,200 BOTH THE RDCRN AND THE PATIENT 1712 01:13:13,200 --> 01:13:14,560 ADVOCACY GROUPS ON THE STRATEGIC 1713 01:13:14,560 --> 01:13:15,640 PLANS. 1714 01:13:15,640 --> 01:13:19,920 THE PUBLIC ROUNDTABLES WERE TWO 1715 01:13:19,920 --> 01:13:21,920 WEEKS AGO WERE VERY GOOD 1716 01:13:21,920 --> 01:13:23,360 WELL-ATTENDED MEETINGS. 1717 01:13:23,360 --> 01:13:25,960 I'LL GIVE A BIT OF THE DETAILS 1718 01:13:25,960 --> 01:13:30,240 IN THE NEXT SLIDES. 1719 01:13:30,240 --> 01:13:31,880 AND TO GET FEEDBACK AND 1720 01:13:31,880 --> 01:13:34,840 REFLECTIONS IF YOU ATTENDED THE 1721 01:13:34,840 --> 01:13:35,320 ROUNDTABLES THEMSELVES. 1722 01:13:35,320 --> 01:13:35,960 AND WE'RE NOT DONE YET. 1723 01:13:35,960 --> 01:13:41,360 WE HAVE A FEW MEETINGS IN JUNE 1724 01:13:41,360 --> 01:13:42,360 AND THERE'S ADDITIONAL MEETINGS 1725 01:13:42,360 --> 01:13:43,720 THAT ARE GOING TO POP UP ON THE 1726 01:13:43,720 --> 01:13:48,840 SCHEDULING RADAR BECAUSE THERE'S 1727 01:13:48,840 --> 01:13:52,280 OTHER GROUPS AND WHERE NCATS CAN 1728 01:13:52,280 --> 01:13:55,080 BE GOING OVER THE NEXT FIVE TO 1729 01:13:55,080 --> 01:14:04,480 10 YEARS. 1730 01:14:04,480 --> 01:14:06,080 WE HAD THREE GENERAL QUESTIONS. 1731 01:14:06,080 --> 01:14:08,200 WHAT ARE THE BIGGEST 1732 01:14:08,200 --> 01:14:11,920 OPPORTUNITIES FOR NCATS TO 1733 01:14:11,920 --> 01:14:13,440 ENGAGE AND TO INVEST OVER THE 1734 01:14:13,440 --> 01:14:15,360 NEXT FIVE TO 10 YEARS. 1735 01:14:15,360 --> 01:14:17,840 THE OTHER ONE WAS WHAT ARE THE 1736 01:14:17,840 --> 01:14:18,800 BIG GAPS AND OPPORTUNITIES WE 1737 01:14:18,800 --> 01:14:20,840 SHOULD BE THINKING ABOUT AND THE 1738 01:14:20,840 --> 01:14:23,840 LAST ONE IS WHAT'S MISSING? 1739 01:14:23,840 --> 01:14:24,480 IS THERE ANYTHING ELSE WE SHOULD 1740 01:14:24,480 --> 01:14:26,840 THINK ABOUT AS WE MOVE FORWARD 1741 01:14:26,840 --> 01:14:27,400 IN TRYING TO ADVANCE 1742 01:14:27,400 --> 01:14:31,720 TRANSLATIONAL SCIENCE? 1743 01:14:31,720 --> 01:14:33,160 AS MANY OF YOU KNOW IF YOU 1744 01:14:33,160 --> 01:14:35,080 PARTICIPATED IN OUR ROUNDTABLES, 1745 01:14:35,080 --> 01:14:37,840 WE HAD THREE QUESTIONS WE BOOKED 1746 01:14:37,840 --> 01:14:40,080 OUT INTO SEPARATE BREAKOUT 1747 01:14:40,080 --> 01:14:40,920 DISCUSSIONS SO WE COULD GET 1748 01:14:40,920 --> 01:14:43,000 DIFFERENT PERSPECTIVES ON THOSE 1749 01:14:43,000 --> 01:14:43,920 SAME QUESTIONS. 1750 01:14:43,920 --> 01:14:48,280 THE BREAKOUT SESSIONS WERE FROM 1751 01:14:48,280 --> 01:14:52,360 THE RESEARCH PERSPECTIVE, 1752 01:14:52,360 --> 01:14:52,960 DIVERSITY, EQUITY, INCLUSION AND 1753 01:14:52,960 --> 01:14:53,840 ACCESSIBILITY PERSPECTIVE. 1754 01:14:53,840 --> 01:14:56,880 COMMUNITY PATIENT ENGAGEMENT 1755 01:14:56,880 --> 01:14:58,200 PERSPECTIVE AND TRAINING AND 1756 01:14:58,200 --> 01:14:58,480 EDUCATION. 1757 01:14:58,480 --> 01:15:04,040 WE HAD A GOOD TURNOUT OF OVER 1758 01:15:04,040 --> 01:15:10,600 200 PARTICIPANTS OVER 300 1759 01:15:10,600 --> 01:15:13,320 REGISTRANTS. 1760 01:15:13,320 --> 01:15:15,080 AND PUBLIC CITIZENS AND 1761 01:15:15,080 --> 01:15:22,160 GOVERNMENT SECTORS. 1762 01:15:22,160 --> 01:15:32,080 NCATS THE FIRST PLAN WAS DATED 1763 01:15:32,080 --> 01:15:35,200 AND THIS IS WHAT WILL SHOW YOU 1764 01:15:35,200 --> 01:15:40,440 AN ICE BREAKER AT THE ROUNDTABLE 1765 01:15:40,440 --> 01:15:42,240 AND WHEN WE HAVE THE QUESTION 1766 01:15:42,240 --> 01:15:43,560 AND THINK OF NCATS WHAT WORDS 1767 01:15:43,560 --> 01:15:52,800 COME TO MIND. 1768 01:15:52,800 --> 01:15:58,480 I FELT LIKE WE WERE SEEN WITH 1769 01:15:58,480 --> 01:15:59,920 THESE WORDS AND THINGS NCATS 1770 01:15:59,920 --> 01:16:01,720 WORK WITH YOU ON AND VIEW 1771 01:16:01,720 --> 01:16:04,080 OURSELVES AS IMPORTANT TO HOW WE 1772 01:16:04,080 --> 01:16:07,120 GET TRANSLATIONS DONE 1773 01:16:07,120 --> 01:16:13,000 EFFICIENTLY AND EFFECTIVELY. 1774 01:16:13,000 --> 01:16:14,000 HERE'S WHAT HAPPENED AT THE 1775 01:16:14,000 --> 01:16:14,280 ROUNDTABLE. 1776 01:16:14,280 --> 01:16:16,600 IF YOU TOOK ONE QUESTION THE 1777 01:16:16,600 --> 01:16:19,120 UNMET NEEDS OR GAPS IN 1778 01:16:19,120 --> 01:16:20,480 TRANSLATION, THAT SHOULD BE 1779 01:16:20,480 --> 01:16:21,600 ADDRESSED BY NCATS. 1780 01:16:21,600 --> 01:16:27,640 THIS IS PRETTY SMALL PRINT BUT 1781 01:16:27,640 --> 01:16:28,320 FROM THE RESEARCH PERSPECTIVE 1782 01:16:28,320 --> 01:16:31,160 WARE GETTING RESPONSES SUCH AS 1783 01:16:31,160 --> 01:16:33,120 WE NEED TO THINK ABOUT 1784 01:16:33,120 --> 01:16:35,160 REPRESENTATIVE IN CLINICAL TRIAL 1785 01:16:35,160 --> 01:16:39,840 OR NEED HUMAN-BASED BIOLOGY 1786 01:16:39,840 --> 01:16:40,720 BASED RESEARCH HUBS AT 1787 01:16:40,720 --> 01:16:41,600 INSTITUTIONS AROUND THE COUNTRY. 1788 01:16:41,600 --> 01:16:43,120 WE THOUGHT ABOUT THIS FROM THE 1789 01:16:43,120 --> 01:16:44,440 COMMUNITY ENGAGEMENT 1790 01:16:44,440 --> 01:16:45,800 PERSPECTIVE. 1791 01:16:45,800 --> 01:16:48,120 WE GOT COMMENTS SUCH AS TRIAL 1792 01:16:48,120 --> 01:16:48,920 READINESS FOR MANY RARE DISEASES 1793 01:16:48,920 --> 01:16:51,120 IS LACKING EVEN IF THERE'S A 1794 01:16:51,120 --> 01:16:55,560 PROMISING THERAPY WE DON'T KNOW 1795 01:16:55,560 --> 01:16:57,040 HOW TO DESIGN A TRIAL. 1796 01:16:57,040 --> 01:16:58,680 FROM THE TRAINING AND EDUCATION 1797 01:16:58,680 --> 01:17:01,200 PERSPECTIVE THERE'S GAPS OR 1798 01:17:01,200 --> 01:17:03,640 UNMET NEEDS WERE FOCUSSED ON THE 1799 01:17:03,640 --> 01:17:07,160 JOURNEY FROM DISCOVERY TO HEALTH 1800 01:17:07,160 --> 01:17:10,920 SOLUTIONS. 1801 01:17:10,920 --> 01:17:13,280 THE FIRST IN HUMAN STUDIES AND 1802 01:17:13,280 --> 01:17:14,800 REGULATORY SCIENCE, 1803 01:17:14,800 --> 01:17:15,200 COMMERCIALIZATION. 1804 01:17:15,200 --> 01:17:17,480 HOW DO WE LEARN ABOUT THAT? 1805 01:17:17,480 --> 01:17:19,480 THAT'S A GAP IN OPPORTUNITY FROM 1806 01:17:19,480 --> 01:17:20,160 THAT SPACE. 1807 01:17:20,160 --> 01:17:22,200 FROM DIVERSITY, EQUITY, 1808 01:17:22,200 --> 01:17:24,440 INCLUSION AND ACCESSIBILITY 1809 01:17:24,440 --> 01:17:26,640 SPACE, THERE WAS A LOT OF 1810 01:17:26,640 --> 01:17:27,680 DISCUSSIONS ABOUT ACCESS. 1811 01:17:27,680 --> 01:17:29,200 HOW DO WE GET NEW TREATMENTS TO 1812 01:17:29,200 --> 01:17:30,720 THE UNDER SERVED COMMUNITIES. 1813 01:17:30,720 --> 01:17:33,760 THIS IS A REFLECTION OF HOW WE 1814 01:17:33,760 --> 01:17:35,640 COULD ASK THE SAME QUESTION AND 1815 01:17:35,640 --> 01:17:43,000 GET A MORE HOLISTIC RESPONSE AND 1816 01:17:43,000 --> 01:17:44,360 IMPRESSIONS FROM THE COMMUNITY 1817 01:17:44,360 --> 01:17:46,560 AND PUBLIC WHAT WE COULD BE 1818 01:17:46,560 --> 01:17:50,000 THINKING ABOUT. 1819 01:17:50,000 --> 01:17:51,840 SO YOU DON'T NEED TO REVIEW ALL 1820 01:17:51,840 --> 01:17:53,440 THESE BUT THESE THE TAKEAWAYS 1821 01:17:53,440 --> 01:17:55,640 FROM THE BREAKOUT DISCUSSIONS 1822 01:17:55,640 --> 01:17:56,760 ACCORDING TO THE FOUR SEPARATE 1823 01:17:56,760 --> 01:17:57,560 BREAKOUT ROOMS. 1824 01:17:57,560 --> 01:18:01,960 WE SEARCHED THROUGH COMMENTS 1825 01:18:01,960 --> 01:18:03,120 ABOUT DISSEMINATION AND 1826 01:18:03,120 --> 01:18:04,480 IMPLEMENTATION AND COMMENTS ON 1827 01:18:04,480 --> 01:18:04,840 PREVENTION. 1828 01:18:04,840 --> 01:18:11,000 I WILL TELL YOU THAT THOSE TWO 1829 01:18:11,000 --> 01:18:12,680 THINGS WERE COMMON TO THE PUBLIC 1830 01:18:12,680 --> 01:18:13,960 ROUNDTABLES AND HEARD MULTIPLE 1831 01:18:13,960 --> 01:18:15,160 TIMES IN THE INTERNAL 1832 01:18:15,160 --> 01:18:21,200 DISCUSSIONS WITH OUR STAFF. 1833 01:18:21,200 --> 01:18:22,360 THERE WERE COMMENTS AROUND DATA 1834 01:18:22,360 --> 01:18:23,640 SHARING AS WELL AND YOU CAN READ 1835 01:18:23,640 --> 01:18:26,040 THEM ON YOUR OWN. 1836 01:18:26,040 --> 01:18:32,200 WE'LL MAKE THIS VIDEO OR WEBINAR 1837 01:18:32,200 --> 01:18:34,640 AVAILABLE LATER FOR SUBSEQUENT 1838 01:18:34,640 --> 01:18:34,920 VIEWING. 1839 01:18:34,920 --> 01:18:35,920 IN DIVERSITY, EQUITY, INCLUSION 1840 01:18:35,920 --> 01:18:36,560 AND ACCESSIBILITY THERE WERE 1841 01:18:36,560 --> 01:18:37,400 MANY COMMENTS ABOUT BUILDING 1842 01:18:37,400 --> 01:18:37,800 TRUST. 1843 01:18:37,800 --> 01:18:40,920 THERE'S ALSO A NEED TO 1844 01:18:40,920 --> 01:18:46,040 UNDERSTAND WHAT TRANSLATIONAL 1845 01:18:46,040 --> 01:18:46,360 I 1846 01:18:46,360 --> 01:18:47,960 SCIENCE IS AND WHAT IT DOES AND 1847 01:18:47,960 --> 01:18:48,760 COMMENTS ABOUT BUILDING BRIDGES 1848 01:18:48,760 --> 01:18:49,960 WITH NEW PARTNERS TO MAKE THAT 1849 01:18:49,960 --> 01:18:55,120 HAPPEN. 1850 01:18:55,120 --> 01:18:55,920 BREAKOUT DISCUSSIONS. 1851 01:18:55,920 --> 01:18:58,000 SEVERAL COMMENTS ABOUT PATIENTS 1852 01:18:58,000 --> 01:19:02,600 AS PARTNERS AND THEY NEED TO BE 1853 01:19:02,600 --> 01:19:03,640 ENGAGED EARLY IN THE PROCESS. 1854 01:19:03,640 --> 01:19:05,960 WE NEED TO HAVE THE COMMUNITY AS 1855 01:19:05,960 --> 01:19:08,520 PART OF THE RESEARCH DESIGN AND 1856 01:19:08,520 --> 01:19:11,120 TO ADDRESS ISSUES OF ACCESS AND 1857 01:19:11,120 --> 01:19:15,480 ADOPTION. 1858 01:19:15,480 --> 01:19:17,520 TRAINING AND EDUCATION 1859 01:19:17,520 --> 01:19:17,920 PERSPECTIVES. 1860 01:19:17,920 --> 01:19:21,120 A FOCUS ON TEAM SCIENCE AND 1861 01:19:21,120 --> 01:19:23,160 TRANSLATIONAL SCIENCE TRAINING 1862 01:19:23,160 --> 01:19:24,800 AND WORKFORCE DIVERSITY. 1863 01:19:24,800 --> 01:19:27,120 THE EDUCATION SPACE THERE WERE 1864 01:19:27,120 --> 01:19:29,200 SEVERAL COMMENTS ABOUT CAREER 1865 01:19:29,200 --> 01:19:29,480 TRANSLATION. 1866 01:19:29,480 --> 01:19:30,640 WE'RE ALSO WORKING WITH PEOPLE 1867 01:19:30,640 --> 01:19:34,880 AS THEY TRY TO MOVE THINGS AND 1868 01:19:34,880 --> 01:19:39,120 ADVANCE THEM TOWARD HOW DO YOU 1869 01:19:39,120 --> 01:19:40,680 THE UNDERSTANDING OF WHAT THE 1870 01:19:40,680 --> 01:19:41,680 TRANSITIONS ARE AND SOME PEOPLE 1871 01:19:41,680 --> 01:19:43,120 WANT TO USE THEM AS A CAREER 1872 01:19:43,120 --> 01:19:46,920 PATHWAY. 1873 01:19:46,920 --> 01:19:49,120 THESE WERE SOME OF THE THINGS WE 1874 01:19:49,120 --> 01:19:51,520 SAW IN THE CROSS-CUTTING AREAS. 1875 01:19:51,520 --> 01:19:55,120 AS I SAID BEFORE, MANY COMMENTS 1876 01:19:55,120 --> 01:19:56,360 ABOUT PREVENTION. 1877 01:19:56,360 --> 01:19:59,160 THERE'S SOME VERY INTERESTING 1878 01:19:59,160 --> 01:20:01,880 ONES ABOUT DON'T JUST MAKE MORE 1879 01:20:01,880 --> 01:20:03,000 TREATMENTS, MAKE BETTER 1880 01:20:03,000 --> 01:20:03,280 TREATMENTS. 1881 01:20:03,280 --> 01:20:05,680 LET'S FOCUS ON THE CAUSES OF 1882 01:20:05,680 --> 01:20:08,000 THOSE DISEASES NOT JUST THE 1883 01:20:08,000 --> 01:20:08,840 TREATMENTS. 1884 01:20:08,840 --> 01:20:10,040 AGAIN, DISSEMINATION AND 1885 01:20:10,040 --> 01:20:11,120 IMPLEMENTATION WAS A FREQUENT 1886 01:20:11,120 --> 01:20:17,720 COMMENT. 1887 01:20:17,720 --> 01:20:19,000 THERE WERE SEVERAL COMMENTS 1888 01:20:19,000 --> 01:20:21,800 ABOUT NCATS CAN DO SOMETHING 1889 01:20:21,800 --> 01:20:22,400 ABOUT NOVEL CLINICAL TRIAL 1890 01:20:22,400 --> 01:20:24,800 APPROACHES AND HOW DO WE MAKE 1891 01:20:24,800 --> 01:20:26,400 THAT MORE BROADLY ACCESSIBLE AND 1892 01:20:26,400 --> 01:20:26,960 DISSEMINATE THAT. 1893 01:20:26,960 --> 01:20:29,360 HEALTH EQUITY HAS BEEN A HUGE 1894 01:20:29,360 --> 01:20:31,120 DISCUSSION NOT ONLY IN THE 1895 01:20:31,120 --> 01:20:38,000 PUBLIC REALM BUT ALSO IN THE 1896 01:20:38,000 --> 01:20:39,680 INTERNAL DISCUSSION AND MORE 1897 01:20:39,680 --> 01:20:41,280 PARTNERSHIPS AND COLLABORATIONS 1898 01:20:41,280 --> 01:20:45,160 AND PATIENTS HAVE TO BE AN 1899 01:20:45,160 --> 01:20:46,560 IMPORTANT PART OF THAT TEAM. 1900 01:20:46,560 --> 01:20:52,120 THERE WERE COMMENTS ABOUT MAKING 1901 01:20:52,120 --> 01:20:56,000 BRIDGES AND HELPING WITH THE 1902 01:20:56,000 --> 01:20:58,480 ADVANCEMENT TO THE NEXT SECTOR 1903 01:20:58,480 --> 01:20:59,400 WHETHER DECISION MAKE ORG 1904 01:20:59,400 --> 01:21:01,480 BUSINESS OR WHAT HAVE YOU. 1905 01:21:01,480 --> 01:21:04,200 WE WANT TO REDUCE ADMINISTRATIVE 1906 01:21:04,200 --> 01:21:06,200 BURDEN AND HELP IN RESEARCH AND 1907 01:21:06,200 --> 01:21:08,400 CARE AND HELP FOSTER A 1908 01:21:08,400 --> 01:21:12,840 TRANSLATIONAL SCIENCE WORKFORCE. 1909 01:21:12,840 --> 01:21:15,280 BEFORE I HAND THIS OVER TO JONI 1910 01:21:15,280 --> 01:21:20,160 FOR DISCUSSION, I WANTED TO 1911 01:21:20,160 --> 01:21:21,360 ACKNOWLEDGE THE TEAM HERE THAT 1912 01:21:21,360 --> 01:21:22,640 HAS TAKEN US TO THIS POINT IN 1913 01:21:22,640 --> 01:21:24,360 THE PROCESS AND STILL HAVE MORE 1914 01:21:24,360 --> 01:21:25,520 TO GO. 1915 01:21:25,520 --> 01:21:30,480 WE HAVE OUR STRATEGIC PLANNING 1916 01:21:30,480 --> 01:21:37,680 TEAM WHICH HAS BEEN FOCUSSED ON 1917 01:21:37,680 --> 01:21:39,120 GETTING THIS OFF THE GROUND AND 1918 01:21:39,120 --> 01:21:41,280 WE'LL WORK ON THE DRAFT. 1919 01:21:41,280 --> 01:21:42,040 COMMUNICATIONS, I.T. AND WORK 1920 01:21:42,040 --> 01:21:46,120 TEAMS HAVE HELPED DISSEMINATION 1921 01:21:46,120 --> 01:21:47,480 OF THE INFORMATION AND OUTREACH 1922 01:21:47,480 --> 01:21:50,200 TO THE PUBLIC AND STAKEHOLDERS. 1923 01:21:50,200 --> 01:21:52,680 AND IN THE ROUNDTABLE I WANTED 1924 01:21:52,680 --> 01:21:56,000 TO THANK THE NCATS LEADERSHIP 1925 01:21:56,000 --> 01:21:58,360 THAT HELPED WITH THE BREAKOUT 1926 01:21:58,360 --> 01:21:58,680 DISCUSSIONS. 1927 01:21:58,680 --> 01:22:03,120 I THINK THEY WERE RICH IN 1928 01:22:03,120 --> 01:22:06,640 DISCUSSION AND HAVE BEEN 1929 01:22:06,640 --> 01:22:08,360 BENEFICIAL IN MOVING FORWARD. 1930 01:22:08,360 --> 01:22:11,120 AND WITH THAT I'M GOING TO HAND 1931 01:22:11,120 --> 01:22:12,920 THIS TO YOU IN TERMS OF HOW WE 1932 01:22:12,920 --> 01:22:13,800 CAN HAVE A COUNCIL DISCUSSION 1933 01:22:13,800 --> 01:22:23,120 AND THEN MOVE FORWARD. 1934 01:22:23,120 --> 01:22:30,760 >>THANK YOU VERY MUCH. 1935 01:22:30,760 --> 01:22:32,920 AND WE HAVE A VARIETY OF NCATS 1936 01:22:32,920 --> 01:22:35,120 STAFF THAT ARE LISTENING IN AND 1937 01:22:35,120 --> 01:22:37,960 HAVE BEEN A PART OF THE 1938 01:22:37,960 --> 01:22:38,560 PROCESSES AND MAY ENGAGE AS 1939 01:22:38,560 --> 01:22:48,640 WELL. 1940 01:22:49,680 --> 01:22:51,120 AND I WANT TO TALK ABOUT THE 1941 01:22:51,120 --> 01:22:54,120 PROCESS AND PARTICIPATION FROM 1942 01:22:54,120 --> 01:22:54,800 THE COUNCIL MEMBERS IN OUR OWN 1943 01:22:54,800 --> 01:23:00,880 LITTLE ROUNDTABLE IF YOU WILL. 1944 01:23:00,880 --> 01:23:03,000 LARGELY I'M INTERESTED AND I 1945 01:23:03,000 --> 01:23:04,760 KNOW SOME HAVE BEEN A PART OF 1946 01:23:04,760 --> 01:23:09,000 THE ROUNDTABLE DISCUSSIONS AND 1947 01:23:09,000 --> 01:23:09,440 SER 1948 01:23:09,440 --> 01:23:10,200 SERGIO, THANK YOU FOR YOUR 1949 01:23:10,200 --> 01:23:11,160 COMMENTS ON THE IMPORTANCE AND 1950 01:23:11,160 --> 01:23:13,240 THINKING ABOUT THE COMMUNITY 1951 01:23:13,240 --> 01:23:14,480 ENGAGEMENT THAT'S HAPPENING. 1952 01:23:14,480 --> 01:23:20,000 I'M ALSO WONDERING FROM YOU ALL 1953 01:23:20,000 --> 01:23:23,960 THAT FROM THOSE ABLE TO 1954 01:23:23,960 --> 01:23:25,600 PARTICIPATE WHAT HAS STUCK OUT 1955 01:23:25,600 --> 01:23:27,920 TO YOU IN TERMS OF THE 1956 01:23:27,920 --> 01:23:28,440 ROUNDTABLE DISCUSSIONS? 1957 01:23:28,440 --> 01:23:34,840 AND EVEN IN THESE FOUR AREAS 1958 01:23:34,840 --> 01:23:37,800 THAT WAS MENTIONED WITH 1959 01:23:37,800 --> 01:23:38,440 DIVERSITY, EQUITY, INCLUSION AND 1960 01:23:38,440 --> 01:23:43,120 ACCESSIBILITY AND RESEARCH AND 1961 01:23:43,120 --> 01:23:44,800 COMMUNITY ENGAGEMENT AND PATIENT 1962 01:23:44,800 --> 01:23:46,880 AND TRAINING AND ENGAGEMENT. 1963 01:23:46,880 --> 01:23:49,240 THESE ARE KEY THEMES THE BASIS 1964 01:23:49,240 --> 01:23:51,640 OF WHERE WE CAN EXPLORE 1965 01:23:51,640 --> 01:23:52,600 DEVELOPING A STRATEGIC PLANNING. 1966 01:23:52,600 --> 01:23:55,960 THESE IDEA ARE MEANT TO CUT 1967 01:23:55,960 --> 01:23:58,000 ACROSS ALL THESE DIFFERENT AREAS 1968 01:23:58,000 --> 01:24:01,040 AND WHERE CAN WE PROVIDE THAT 1969 01:24:01,040 --> 01:24:02,040 PRIORITIZATION AND INPUT FROM 1970 01:24:02,040 --> 01:24:03,800 THE THINGS THAT HAVE JUMPED OUT 1971 01:24:03,800 --> 01:24:07,200 AT YOU DURING THE ROUNDTABLE 1972 01:24:07,200 --> 01:24:07,800 DISCUSSIONS? 1973 01:24:07,800 --> 01:24:09,480 I'D LIKE TO HEAR WHAT YOUR 1974 01:24:09,480 --> 01:24:11,360 COMMENTS AND INPUT WOULD BE FROM 1975 01:24:11,360 --> 01:24:13,120 YOUR OWN PARTICIPATION AND THEN 1976 01:24:13,120 --> 01:24:14,760 I'D LOVE TO HEAR -- WE'LL GO 1977 01:24:14,760 --> 01:24:17,560 INTO OTHER QUESTIONS THAT I'LL 1978 01:24:17,560 --> 01:24:18,480 ASK AROUND THE STRATEGIC 1979 01:24:18,480 --> 01:24:20,000 PLANNING PROCESS AND SOME 1980 01:24:20,000 --> 01:24:22,960 QUESTIONS I'D LIKE TO ASK YOU. 1981 01:24:22,960 --> 01:24:25,280 WOULD ANYBODY WANT TO JUMP IN 1982 01:24:25,280 --> 01:24:30,680 AND PROVIDE COMMENTS AROUND THE 1983 01:24:30,680 --> 01:24:37,520 ROUNDTABLE TABLES? 1984 01:24:37,520 --> 01:24:39,640 >>I HAD A CHANCE TO ATTEND THE 1985 01:24:39,640 --> 01:24:39,920 ROUNDTABLE. 1986 01:24:39,920 --> 01:24:41,880 I THOUGHT THE WAY IT WAS 1987 01:24:41,880 --> 01:24:50,600 STRUCTURED WAS VERY INNOVATIVE. 1988 01:24:50,600 --> 01:24:52,320 YOU ASK THE QUESTION WITH 1989 01:24:52,320 --> 01:24:53,040 DIFFERENT GROUPS THAT HAD 1990 01:24:53,040 --> 01:24:58,320 DIFFERENT PERSPECTIVES AND WHAT 1991 01:24:58,320 --> 01:25:00,440 WAS INTERESTING WAS SEEING HOW 1992 01:25:00,440 --> 01:25:02,040 THAT WERE THEMES THAT CAME OUT 1993 01:25:02,040 --> 01:25:06,440 AND TIED TOGETHER AND SHOWED HOW 1994 01:25:06,440 --> 01:25:08,720 AS EXPECTED DIFFERENT GROUPS TIE 1995 01:25:08,720 --> 01:25:09,640 TOGETHER A SYSTEMS APPROACH TO 1996 01:25:09,640 --> 01:25:15,880 ACHIEVE THE GOALS. 1997 01:25:15,880 --> 01:25:18,080 FOR EXAMPLE TRYING TO BUILD OUT 1998 01:25:18,080 --> 01:25:21,240 AND EXPAND THE TRANSLATIONAL 1999 01:25:21,240 --> 01:25:22,840 SCIENCE WORKFORCE IS ALL THAT 2000 01:25:22,840 --> 01:25:25,120 MATTERS IN TRYING TO GET MORE 2001 01:25:25,120 --> 01:25:26,160 TREATMENT MORE QUICKLY. 2002 01:25:26,160 --> 01:25:27,920 THERE'S JOB DESCRIPTIONS WE 2003 01:25:27,920 --> 01:25:29,560 PROBABLY DON'T EVEN KNOW OR 2004 01:25:29,560 --> 01:25:31,960 THINK ABOUT YET THAT NEED TO BE 2005 01:25:31,960 --> 01:25:33,960 THERE PARTICULARLY IN INDUSTRY 2006 01:25:33,960 --> 01:25:37,240 IF WE WANT TO TAKE THIS FAR. 2007 01:25:37,240 --> 01:25:43,040 SEGUE INTO THAT ONE OF THE 2008 01:25:43,040 --> 01:25:47,080 SUGGESTIONS MADE MAYBE HAVING AN 2009 01:25:47,080 --> 01:25:47,880 INDUSTRY-SPECIFIC ROUNDTABLE AS 2010 01:25:47,880 --> 01:25:48,840 SHOWN IN THE NUMBERS. 2011 01:25:48,840 --> 01:25:54,080 THERE WASN'T A HUGE 2012 01:25:54,080 --> 01:25:54,720 PARTICIPATION FROM INDUSTRY BUT 2013 01:25:54,720 --> 01:25:56,920 HAVING THEIR INPUT FOR THE GOAL 2014 01:25:56,920 --> 01:26:01,680 YOU'RE TRYING TO ACHIEVE IS KEY 2015 01:26:01,680 --> 01:26:03,720 AND ALSO AN OPPORTUNITY TO GET 2016 01:26:03,720 --> 01:26:05,960 MORE TO INDUSTRY AND NCATS AS 2017 01:26:05,960 --> 01:26:07,080 YOU'RE DOING HERE. 2018 01:26:07,080 --> 01:26:08,080 ANOTHER THING THAT STUCK OUT 2019 01:26:08,080 --> 01:26:17,280 THAT CAME UP A COUPLE TIMES WAS 2020 01:26:17,280 --> 01:26:19,120 COST WHICH IS PROBABLY NOT IN 2021 01:26:19,120 --> 01:26:20,520 YOUR WHEELHOUSE BUT THERE WAS A 2022 01:26:20,520 --> 01:26:22,960 TIME WHERE WE CAN GET THINGS 2023 01:26:22,960 --> 01:26:24,960 MORE EFFICIENTLY OUT THE COST 2024 01:26:24,960 --> 01:26:27,160 WOULD DROP. 2025 01:26:27,160 --> 01:26:29,320 AT LEAST RECOGNIZING THE COST TO 2026 01:26:29,320 --> 01:26:36,520 HEALTH EQUITY AND ACCESS IS A 2027 01:26:36,520 --> 01:26:39,240 GOAL. 2028 01:26:39,240 --> 01:26:40,440 PARTICULARLY WITH SELLING GENE 2029 01:26:40,440 --> 01:26:42,000 THERAPY WE KNOW IS EXPENSIVE. 2030 01:26:42,000 --> 01:26:48,760 >>THANK YOU FOR THE COMMEN 2031 01:26:48,760 --> 01:26:49,120 COMMENTS,ANIKA. 2032 01:26:49,120 --> 01:26:51,480 >>I LOVE THE IDEA OF A MORE 2033 01:26:51,480 --> 01:26:55,880 SPECIFIC WAY OF ENGAGING 2034 01:26:55,880 --> 01:26:57,160 INDUSTRY AND DOING A ROUNDTABLE. 2035 01:26:57,160 --> 01:26:59,160 THAT'S A GREAT IDEA AND WE CAN 2036 01:26:59,160 --> 01:27:03,920 CERTAINLY INCORPORATE THAT TOO. 2037 01:27:03,920 --> 01:27:06,000 AND I THINK IT'S IMPORTANT TOO 2038 01:27:06,000 --> 01:27:08,320 BECAUSE WHEN YOU MENTIONED THE 2039 01:27:08,320 --> 01:27:09,560 IDEA OF THE WORKFORCE AND 2040 01:27:09,560 --> 01:27:11,120 THINKING ABOUT ALL THESE JOBS 2041 01:27:11,120 --> 01:27:12,520 OUT THERE THAT WE DIDN'T EVEN 2042 01:27:12,520 --> 01:27:14,600 KNOW ABOUT YET BUT WE NEED TO 2043 01:27:14,600 --> 01:27:18,400 BUILD A DIFFERENT WORKFORCE FOR 2044 01:27:18,400 --> 01:27:20,000 WHERE WE'RE GOING BIOMEDICAL 2045 01:27:20,000 --> 01:27:20,840 SCIENCES AND THINKING FOR 2046 01:27:20,840 --> 01:27:23,800 EXAMPLE SOME OF THE WORK WE'RE 2047 01:27:23,800 --> 01:27:26,000 DOING IN THE WINDOW THAT I 2048 01:27:26,000 --> 01:27:28,720 TALKED SOMEWHAT ABOUT TODAY IN 2049 01:27:28,720 --> 01:27:30,880 TERMS OF GENE THERAPY AND 2050 01:27:30,880 --> 01:27:34,920 DEVELOPMENT OF GENE THERAPY 2051 01:27:34,920 --> 01:27:37,840 PROGRAMS, THE DELIVERY, THE 2052 01:27:37,840 --> 01:27:39,840 OTHER NON-VIRAL KIND OF DELIVERY 2053 01:27:39,840 --> 01:27:42,840 AND THE WORK THAT NEEDS TO GO ON 2054 01:27:42,840 --> 01:27:45,760 IN THAT SPACE AND TRANSLATING 2055 01:27:45,760 --> 01:27:49,600 THAT TO THE CLINICAL SPACE AND 2056 01:27:49,600 --> 01:27:50,400 THINKING ABOUT THE MANUFACTURING 2057 01:27:50,400 --> 01:27:52,480 WORK AND CLINICAL TRIAL WORK AND 2058 01:27:52,480 --> 01:27:54,600 QUALITY WORK AND DRUG 2059 01:27:54,600 --> 01:27:55,960 DEVELOPMENT WORK. 2060 01:27:55,960 --> 01:27:58,560 THESE ARE FAIRLY NASCENT FIELDS 2061 01:27:58,560 --> 01:28:00,880 WHERE I THINK WE REALLY DO NEED 2062 01:28:00,880 --> 01:28:02,000 TO THINK ABOUT WHAT'S THE 2063 01:28:02,000 --> 01:28:05,240 WORKFORCE NEEDED TO DO THAT AND 2064 01:28:05,240 --> 01:28:06,200 THAT WORKFORCE NEEDS TO BE AT 2065 01:28:06,200 --> 01:28:06,880 EVERY LEVEL FOR SURE. 2066 01:28:06,880 --> 01:28:12,360 I LIKE THE IDEA OF TRAYING TO 2067 01:28:12,360 --> 01:28:14,160 -- TRYING TO MAP THAT OUT AND 2068 01:28:14,160 --> 01:28:15,360 WORKING ONE THE WORKFORCE TO 2069 01:28:15,360 --> 01:28:17,080 HELP UNDERSTAND THE 2070 01:28:17,080 --> 01:28:18,200 POSSIBILITIES OF A CAREER IN 2071 01:28:18,200 --> 01:28:23,200 SCIENCE TO ADVANCE THESE 2072 01:28:23,200 --> 01:28:27,120 ACTIVITIES AND THE OTHER SPACE 2073 01:28:27,120 --> 01:28:28,880 IN THE PRECLINICAL SIZE I THINK 2074 01:28:28,880 --> 01:28:34,880 OF THE HUMAN-BASED CELL MODELS 2075 01:28:34,880 --> 01:28:35,760 WE'RE TRYING TO DEVELOP AS WELL 2076 01:28:35,760 --> 01:28:37,800 WE KNOW THERE'S A 90% OF FAILURE 2077 01:28:37,800 --> 01:28:39,680 RATE OF DRUG CANDIDATES THAT 2078 01:28:39,680 --> 01:28:43,120 MOVE INTO CLINICAL TRIALS AND 2079 01:28:43,120 --> 01:28:44,920 MOST IS IN THE CLINICAL TRIAL 2080 01:28:44,920 --> 01:28:47,120 SPACE AND PRE-CLINICAL AND 2081 01:28:47,120 --> 01:28:50,000 CLINICAL ASPECTS CONTRIBUTE AND 2082 01:28:50,000 --> 01:28:54,760 ON THE CLINICAL SIDE AND 2083 01:28:54,760 --> 01:28:57,000 UNDERSTANDING THE RODENT MODEL 2084 01:28:57,000 --> 01:28:58,200 HAVE BEEN THE GOLD STANDARD 2085 01:28:58,200 --> 01:28:59,360 FOREVER ARE REALLY NOT CUTTING 2086 01:28:59,360 --> 01:29:01,520 IT FOR WHAT WE NEED TO DO IN 2087 01:29:01,520 --> 01:29:05,200 TERMS OF DRUG DEVELOPMENT. 2088 01:29:05,200 --> 01:29:06,920 REENGINEERING USING DIFFERENT 2089 01:29:06,920 --> 01:29:08,640 DISCIPLINES AND BACKGROUNDS TO 2090 01:29:08,640 --> 01:29:10,720 DEVELOP THE MODELS MORE 2091 01:29:10,720 --> 01:29:12,080 HUMAN-CELL BASED AND FIT FOR 2092 01:29:12,080 --> 01:29:13,760 PURPOSE FOR THE KIND OF DRUG 2093 01:29:13,760 --> 01:29:14,720 DEVELOPMENT PROGRAMS WE'LL BE 2094 01:29:14,720 --> 01:29:17,640 DOING IS ALSO IMPORTANT IN 2095 01:29:17,640 --> 01:29:19,360 BRINGING IN THAT TRANS 2096 01:29:19,360 --> 01:29:20,600 DISCIPLINARY SCIENCE IS 2097 01:29:20,600 --> 01:29:22,440 SOMETHING WE CAN HELP CONTRIBUTE 2098 01:29:22,440 --> 01:29:24,920 FOR THAT WORKFORCE. 2099 01:29:24,920 --> 01:29:28,440 THESE ARE GREAT COMMENTS AND 2100 01:29:28,440 --> 01:29:30,400 ANIKA I KNOW THERE'S PROBABLY A 2101 01:29:30,400 --> 01:29:32,440 LOT OF WORK WE CAN DO ON THIS 2102 01:29:32,440 --> 01:29:33,920 TOGETHER SO THAT'S EXCITE. 2103 01:29:33,920 --> 01:29:34,320 THANK YOU. 2104 01:29:34,320 --> 01:29:40,240 I SEE ROBIN AND ANDY AND SURGIO. 2105 01:29:40,240 --> 01:29:43,480 >>AS YOU WERE TALKING IT 2106 01:29:43,480 --> 01:29:44,680 REMINDED ME OF ANOTHER COMMENT 2107 01:29:44,680 --> 01:29:46,840 THAT COULD BE HELPFUL IN THE 2108 01:29:46,840 --> 01:29:47,520 ATTORNEY GENERAL STRATEGY TO 2109 01:29:47,520 --> 01:29:49,200 HAVE A GRAPHIC OF THE 2110 01:29:49,200 --> 01:29:50,920 TRANSLATIONAL SCIENCE PROCESS. 2111 01:29:50,920 --> 01:29:52,200 I KNOW YOU HAVE THE MAP THAT MAY 2112 01:29:52,200 --> 01:29:54,680 BE HARDER TO DO THIS BUT SOME 2113 01:29:54,680 --> 01:30:00,920 TYPE OF GRAPHIC TO SHOW THE 2114 01:30:00,920 --> 01:30:02,440 PROCESS AND WHERE NCATS PLANS TO 2115 01:30:02,440 --> 01:30:04,040 CONTRIBUTE AS ARTICULATED IN THE 2116 01:30:04,040 --> 01:30:04,600 STRATEGY. 2117 01:30:04,600 --> 01:30:06,520 SO MANY PIECES YOU CAN'T DO IT 2118 01:30:06,520 --> 01:30:09,720 ALL BUT I THINK THE GRAPHIC MAY 2119 01:30:09,720 --> 01:30:11,560 HELP ARTICULATE WHERE NCATS IS 2120 01:30:11,560 --> 01:30:12,760 PLANNING TO CONTRIBUTE BUT THEN 2121 01:30:12,760 --> 01:30:14,080 SHOWS THE LINKAGE OF WHAT THAT 2122 01:30:14,080 --> 01:30:16,160 MEANS TO THE DOWN STREAM OR 2123 01:30:16,160 --> 01:30:26,640 UPSTREAM PIECES. 2124 01:30:26,640 --> 01:30:29,160 VISUALS ARE HELPFUL SO IT WOULD 2125 01:30:29,160 --> 01:30:33,280 GO A LONG WAY IN TRANSLATIONAL 2126 01:30:33,280 --> 01:30:35,120 RESEARCH TO GET TO THE WORK WE 2127 01:30:35,120 --> 01:30:37,040 CAN DO SINCE WE CAN'T DO 2128 01:30:37,040 --> 01:30:38,840 EVERYTHING WHERE CAN WE 2129 01:30:38,840 --> 01:30:40,760 PRIORITIZE AND WHERE CAN THEY BE 2130 01:30:40,760 --> 01:30:41,520 MORE TANGIBLE. 2131 01:30:41,520 --> 01:30:49,560 ROBIN AND THEN ANDY AND THEN 2132 01:30:49,560 --> 01:30:49,880 SERGIO. 2133 01:30:49,880 --> 01:30:58,520 >>I ALSO THOUGHT THIS WAS 2134 01:30:58,520 --> 01:30:59,000 ENJOYABLE. 2135 01:30:59,000 --> 01:31:05,000 I LOVE HELPING MORE PEOPLE MORE 2136 01:31:05,000 --> 01:31:10,320 QUICKLY BUT MY GUT SAYS IT'S 2137 01:31:10,320 --> 01:31:12,600 GOOD STUFF BUT THE SLOGAN 2138 01:31:12,600 --> 01:31:17,400 DOESN'T CAPTURE ALL THE 2139 01:31:17,400 --> 01:31:17,960 COMMUNICATION. 2140 01:31:17,960 --> 01:31:22,920 PREVENTION AND ON COVID, YOU'RE 2141 01:31:22,920 --> 01:31:24,320 PREVENTING DEATHS AND 2142 01:31:24,320 --> 01:31:26,840 HOSPITALIZATION WHICH IS GOOD 2143 01:31:26,840 --> 01:31:29,120 BUT I THINK MOST PEOPLE WOULD 2144 01:31:29,120 --> 01:31:31,760 RATHER NEVER GET THE DISEASE 2145 01:31:31,760 --> 01:31:32,280 THAN WORRY ABOUT WHAT'S 2146 01:31:32,280 --> 01:31:42,440 TREATABLE. 2147 01:31:51,240 --> 01:31:54,400 I THINK WE'RE MISSING ENGAGING 2148 01:31:54,400 --> 01:31:56,040 ACADEMIC CLINICIANS BUT NOT OUT 2149 01:31:56,040 --> 01:31:57,680 IN THE WORLD CLINICIANS AND 2150 01:31:57,680 --> 01:32:00,240 WHERE THE VAST MAJORITY OF 2151 01:32:00,240 --> 01:32:03,840 PEOPLE GET ACCESS TO HEALTH CARE 2152 01:32:03,840 --> 01:32:07,560 AND HAVE TREATMENTS FOR INTEREST 2153 01:32:07,560 --> 01:32:08,920 IN THE HEALTH CARE SYSTEM AND 2154 01:32:08,920 --> 01:32:10,640 YOU'VE GOT INDUSTRY INPUT BUT I 2155 01:32:10,640 --> 01:32:15,400 DON'T THINK YOU GOT INPUT FROM 2156 01:32:15,400 --> 01:32:17,120 THE MAJOR ORGANIZATIONS THAT WE 2157 01:32:17,120 --> 01:32:23,120 THINK ABOUT THAT RUN MOST OF OUR 2158 01:32:23,120 --> 01:32:26,720 HOSPITALS AND LARGE 2159 01:32:26,720 --> 01:32:28,480 CORPORATIONS. 2160 01:32:28,480 --> 01:32:29,600 THAT ARE THE GAY GATE KEEPERS 2161 01:32:29,600 --> 01:32:31,120 AND TALKING ABOUT IMPLEMENTATION 2162 01:32:31,120 --> 01:32:35,120 AND DISSEMINATION HOW YOU GET 2163 01:32:35,120 --> 01:32:38,600 SOME OF THESE TREATMENTS INTO 2164 01:32:38,600 --> 01:32:39,360 SETTINGS WITH HEALTH CARE. 2165 01:32:39,360 --> 01:32:43,120 MAYBE THINK OF ENGAGING THAT 2166 01:32:43,120 --> 01:32:52,160 SECTOR TOO. 2167 01:32:52,160 --> 01:32:55,080 >>I WANTED TO RESPOND 2168 01:32:55,080 --> 01:32:56,680 CONSISTENTLY IN OUR INTERNAL 2169 01:32:56,680 --> 01:32:58,560 ROUNDTABLE AND EXTERNAL 2170 01:32:58,560 --> 01:32:58,880 ROUNDTABLE. 2171 01:32:58,880 --> 01:33:02,280 I'D CALL IT THE FIRST MODEL/LAST 2172 01:33:02,280 --> 01:33:03,720 MODEL OF TRANSLATION WHERE IF WE 2173 01:33:03,720 --> 01:33:09,720 DEVELOP ALL THESE TREATMENTS AND 2174 01:33:09,720 --> 01:33:10,880 IT NEVER GETS TO THE PEOPLE AND 2175 01:33:10,880 --> 01:33:13,120 IF WE DEVELOP THE TREATMENTS OR 2176 01:33:13,120 --> 01:33:15,720 THINK ABOUT DIFFERENT WAYS TO 2177 01:33:15,720 --> 01:33:18,880 PREVENT OR MINIMIZE POTENTIAL 2178 01:33:18,880 --> 01:33:20,400 DISEASES IN THE FIRST PLACE AND 2179 01:33:20,400 --> 01:33:22,560 WE HAVE THE TECHNOLOGY TO DO IT 2180 01:33:22,560 --> 01:33:26,520 BUT WE DON'T ADDRESS IT AND SO 2181 01:33:26,520 --> 01:33:29,800 WE'RE HEARING THIS VERY LOUD AND 2182 01:33:29,800 --> 01:33:32,480 CLEAR FROM BOTH OUR INTERNAL 2183 01:33:32,480 --> 01:33:35,240 STAKEHOLDERS AS WELL AS OUR 2184 01:33:35,240 --> 01:33:36,040 EXTERNAL ONES. 2185 01:33:36,040 --> 01:33:37,400 I APPRECIATE THAT COMMENT AND 2186 01:33:37,400 --> 01:33:39,640 I'M SURE IT WILL BE SOMETHING 2187 01:33:39,640 --> 01:33:47,320 THAT WE WILL HOLD IN AS WE HAVE 2188 01:33:47,320 --> 01:33:47,800 THE COMMUNICATION. 2189 01:33:47,800 --> 01:33:49,040 WE THINK WE'VE GOT IT BUT IT'S 2190 01:33:49,040 --> 01:33:51,440 NOT GETTING OUT THERE. 2191 01:33:51,440 --> 01:33:52,920 >>YEAH. 2192 01:33:52,920 --> 01:33:55,120 AND TO THAT POINT TOO, I AGREE 2193 01:33:55,120 --> 01:33:57,880 WITH PENNY WE HEARD THIS A BIT 2194 01:33:57,880 --> 01:33:59,720 AND I AGREE WITH THIS COMMENT. 2195 01:33:59,720 --> 01:34:01,920 I THINK WE NEED TO FIGURE OUT 2196 01:34:01,920 --> 01:34:05,320 HOW WE CAN DO THIS BETTER AND 2197 01:34:05,320 --> 01:34:06,240 ESPECIALLY IN THE IDEA OF 2198 01:34:06,240 --> 01:34:07,120 DISSEMINATION AND 2199 01:34:07,120 --> 01:34:12,400 IMPLEMENTATION. 2200 01:34:12,400 --> 01:34:15,920 WE CAN DO A GOOD JOB 2201 01:34:15,920 --> 01:34:17,600 DISSEMINATING BY PUBLISHING 2202 01:34:17,600 --> 01:34:18,640 PAPERS BUT THAT'S NOT WHAT WE 2203 01:34:18,640 --> 01:34:20,000 MEAN AND MAKE SURE THE WORK 2204 01:34:20,000 --> 01:34:21,680 WE'RE DOING CAN BE ADOPTED. 2205 01:34:21,680 --> 01:34:24,160 HOW CAN IT BE ADOPT? 2206 01:34:24,160 --> 01:34:27,120 HOW CAN WE INCENTIVIZE THAT 2207 01:34:27,120 --> 01:34:30,840 ADOPTION IS WHAT WE WANT WITH 2208 01:34:30,840 --> 01:34:31,800 DISSEMINATION AND 2209 01:34:31,800 --> 01:34:32,160 IMPLEMENTATION. 2210 01:34:32,160 --> 01:34:34,120 WHEN YOU TALK ABOUT THE IDEA OF 2211 01:34:34,120 --> 01:34:36,760 REACHING THE CLINICIANS OUT IN 2212 01:34:36,760 --> 01:34:37,840 THE COMMUNITIES WHO AREN'T 2213 01:34:37,840 --> 01:34:43,120 REALLY ASSOCIATED WITH THE 2214 01:34:43,120 --> 01:34:45,160 ACADEMIC ORGANIZATIONS, WE STILL 2215 01:34:45,160 --> 01:34:46,720 HAVE A LOT OF WORK TO DO WITH 2216 01:34:46,720 --> 01:34:48,280 THE ACADEMIC COMMUNITIES. 2217 01:34:48,280 --> 01:34:54,400 HOW CAN WE PUSH THE ENVELOPE AND 2218 01:34:54,400 --> 01:35:00,600 GET IT OUT TO THE COMMUNITIES TO 2219 01:35:00,600 --> 01:35:05,200 ADOPT AND TALKING TO THE C SUITE 2220 01:35:05,200 --> 01:35:06,280 PEOPLE MAY HAVE INTERESTING 2221 01:35:06,280 --> 01:35:12,000 INSIGHT AND THAT'S A GREAT IDEA. 2222 01:35:12,000 --> 01:35:12,320 THANK YOU. 2223 01:35:12,320 --> 01:35:12,880 THE DEI PIECE IS REALLY 2224 01:35:12,880 --> 01:35:22,120 IMPORTANT. 2225 01:35:22,120 --> 01:35:22,320 ANNIE. 2226 01:35:22,320 --> 01:35:26,560 >>I THINK THE ROUNDTABLE TABLES 2227 01:35:26,560 --> 01:35:27,640 HAVE BEEN PHENOMENAL AND THEY'RE 2228 01:35:27,640 --> 01:35:29,840 MORE OF A LISTENING TOUR BECAUSE 2229 01:35:29,840 --> 01:35:35,120 I'M STRUCK WITH THE ENGAGEMENT 2230 01:35:35,120 --> 01:35:40,800 SO THANK YOU. 2231 01:35:40,800 --> 01:35:46,840 THE ONE THING I PARTICIPATED IN 2232 01:35:46,840 --> 01:35:48,000 WAS THERE WAS A LOT OF DIVERSITY 2233 01:35:48,000 --> 01:35:49,520 IN THE TYPES OF STAKEHOLDERS IN 2234 01:35:49,520 --> 01:35:52,200 THE BREAKOUTS I WAS A PART OF. 2235 01:35:52,200 --> 01:35:57,600 IT WASN'T THE USUAL SUSPECTS AS 2236 01:35:57,600 --> 01:36:00,440 IF YOU WERE TO HAVE AN IN PERSON 2237 01:36:00,440 --> 01:36:02,640 NCATS MEETING SO HOI THAT WAS 2238 01:36:02,640 --> 01:36:04,440 ANNOUNCED WAS EFFECTIVE AND 2239 01:36:04,440 --> 01:36:06,200 THERE WERE DIFFERENT IDEAS AND 2240 01:36:06,200 --> 01:36:07,800 DISCUSSIONS COMING FORWARD AND I 2241 01:36:07,800 --> 01:36:09,560 WANT TO COMMEND THE FACILITATOR 2242 01:36:09,560 --> 01:36:14,920 FOR MANAGING AND WELCOMING ALL 2243 01:36:14,920 --> 01:36:15,880 COMMENTS AND GIVING SPACE FOR 2244 01:36:15,880 --> 01:36:21,000 EVERYBODY TO EXCHANGE THEIR 2245 01:36:21,000 --> 01:36:21,200 IDEAS. 2246 01:36:21,200 --> 01:36:24,000 THE ONE THING THAT STRUCK ME IS 2247 01:36:24,000 --> 01:36:26,000 THE IDEAS AND SUGGESTIONS COMING 2248 01:36:26,000 --> 01:36:29,160 IN OPENED THE DOOR FOR 2249 01:36:29,160 --> 01:36:30,960 OPPORTUNITY FOR NCATS TO 2250 01:36:30,960 --> 01:36:32,840 ELEVATE, OPTIMIZE, SHINE A LIGHT 2251 01:36:32,840 --> 01:36:36,360 ON THE EXISTING RESOURCES PART 2252 01:36:36,360 --> 01:36:37,480 OF THE STRATEGY PLANNING OR 2253 01:36:37,480 --> 01:36:39,120 STRATEGIC DOING WHICH I THINK 2254 01:36:39,120 --> 01:36:44,000 WAS FRAMED IN SOME OF MEETINGS 2255 01:36:44,000 --> 01:36:45,320 DOESN'T MEAN WE HAVE TO START 2256 01:36:45,320 --> 01:36:47,480 OVER OR BUILD ON NEW. 2257 01:36:47,480 --> 01:36:48,960 THE RESOURCES NCATS ALREADY HAS 2258 01:36:48,960 --> 01:36:52,640 THAT CAN BE UPDATED OR 2259 01:36:52,640 --> 01:36:54,800 REPURPOSED OR GIVEN NEW LIFE 2260 01:36:54,800 --> 01:36:56,880 THAT BECAUSE OF THE LISTENING 2261 01:36:56,880 --> 01:36:58,440 TOURS YOU'RE REACHING A BROADER 2262 01:36:58,440 --> 01:37:00,600 AUDIENCE NOW WHO MAY NOT BE 2263 01:37:00,600 --> 01:37:04,160 FAMILIAR WITH SOME OF WHAT IS 2264 01:37:04,160 --> 01:37:04,520 ALREADY HERE. 2265 01:37:04,520 --> 01:37:07,320 THIS IS THE OPPORTUNITY TO 2266 01:37:07,320 --> 01:37:09,280 REPACKAGE IT AND PUSH IT BACK 2267 01:37:09,280 --> 01:37:11,600 OUT TO A BROADER AUDIENCE. 2268 01:37:11,600 --> 01:37:12,640 TO THINK ABOUT THAT A LITTLE BIT 2269 01:37:12,640 --> 01:37:14,000 AND TO PARTNER WITH SOME OF US 2270 01:37:14,000 --> 01:37:16,000 IN THINKING HOW TO DO THAT. 2271 01:37:16,000 --> 01:37:17,360 THAT WOULD BE ONE COMMENT. 2272 01:37:17,360 --> 01:37:20,560 THE OTHER IS I WAS LISTENING TO 2273 01:37:20,560 --> 01:37:21,240 YOUR PRESENTATION JUST A LITTLE 2274 01:37:21,240 --> 01:37:27,120 BIT AGO AND THINKING ABOUT THE 2275 01:37:27,120 --> 01:37:31,120 WONDERFUL TOUR WE HAD THERE'S A 2276 01:37:31,120 --> 01:37:33,600 LOT OF WORK YOU'RE DOING TO 2277 01:37:33,600 --> 01:37:34,800 CAPTIVATE PEOPLE EARLIER 2278 01:37:34,800 --> 01:37:36,680 UPSTREAM IN THEIR CAREERS. 2279 01:37:36,680 --> 01:37:42,640 THE PROGRAM K-12 EFFORTS TO 2280 01:37:42,640 --> 01:37:44,400 BRING EARLY SCIENTISTS IN AND 2281 01:37:44,400 --> 01:37:46,840 MAYBE YOU'RE DOING IT AND 2282 01:37:46,840 --> 01:37:48,400 LISTENING TOWARDS ASKING ANY OF 2283 01:37:48,400 --> 01:37:49,120 THOSE GROUPS. 2284 01:37:49,120 --> 01:37:50,880 ANYONE IN MEDICAL SCHOOLS OR 2285 01:37:50,880 --> 01:37:52,360 GRAD SCHOOL PROGRAMS WHO ARE NOT 2286 01:37:52,360 --> 01:37:55,120 YET BEING SERVED OR FUNDED 2287 01:37:55,120 --> 01:37:57,120 THROUGH NCATS. 2288 01:37:57,120 --> 01:37:58,240 SOME OF QUESTIONS. 2289 01:37:58,240 --> 01:37:59,960 THESE WILL BE THE STAKEHOLDERS 2290 01:37:59,960 --> 01:38:03,640 WE WANT IN THE ENGAGEMENTS AND 2291 01:38:03,640 --> 01:38:05,480 MAYBE DOING A ROUNDTABLE WITH 2292 01:38:05,480 --> 01:38:08,920 FOLKS WHO AREN'T YET FUNDED BY 2293 01:38:08,920 --> 01:38:14,400 NCATS WHO MAY BE PART OF THE 2294 01:38:14,400 --> 01:38:15,880 INTRAMURAL/EXTRAMURAL PROGRAM 2295 01:38:15,880 --> 01:38:17,520 AND MAY BE A DISTINCT LISTENING 2296 01:38:17,520 --> 01:38:17,720 TOUR. 2297 01:38:17,720 --> 01:38:20,840 AND IN THE LAST DISCUSSION NOT 2298 01:38:20,840 --> 01:38:21,440 JUST THE HEALTH CARE SETTING 2299 01:38:21,440 --> 01:38:23,960 WITH PROVIDERS BUT PAYERS AND 2300 01:38:23,960 --> 01:38:27,120 THEY'RE THE GATE KEEPERS FOR 2301 01:38:27,120 --> 01:38:29,120 WHAT PROVIDERS TALK ABOUT AND 2302 01:38:29,120 --> 01:38:30,640 TALKING ABOUT PAY AS AN 2303 01:38:30,640 --> 01:38:36,760 INTERESTING GROUP THERE AS WELL. 2304 01:38:36,760 --> 01:38:37,880 >>THAT'S A GOOD POINT. 2305 01:38:37,880 --> 01:38:41,200 I AGREE PAYERS ARE IMPORTANT. 2306 01:38:41,200 --> 01:38:43,960 WE'RE STARTING TO INTERSECT A 2307 01:38:43,960 --> 01:38:45,200 LITTLE BIT MORE WITH THOSE 2308 01:38:45,200 --> 01:38:50,000 GROUPS ESPECIALLY IN THE WORK 2309 01:38:50,000 --> 01:39:00,560 WE'VE BEEN DOING WITH THE AREAS 2310 01:39:01,640 --> 01:39:02,640 THAT ARE THE POINTS AND CRITICAL 2311 01:39:02,640 --> 01:39:07,480 TO US. 2312 01:39:07,480 --> 01:39:11,920 I LIKE THAT DISCUSSION. 2313 01:39:11,920 --> 01:39:13,840 I WOULD LOVE TO HEAR HOW TO 2314 01:39:13,840 --> 01:39:15,200 INTERACT WITH THE YOUNG FOLKS 2315 01:39:15,200 --> 01:39:17,200 OUT THERE. 2316 01:39:17,200 --> 01:39:18,760 THOSE WHO ARE MAYBE HIGH SCHOOL 2317 01:39:18,760 --> 01:39:24,000 AND COLLEGE AND HOW TO TALK TO 2318 01:39:24,000 --> 01:39:27,400 THEM ABOUT WHAT WE DO AT THE NIH 2319 01:39:27,400 --> 01:39:28,840 AND THERE'S A CAREER FOR THEM IN 2320 01:39:28,840 --> 01:39:30,960 SCIENCE THAT CAN BE FULLY 2321 01:39:30,960 --> 01:39:36,200 SUPPORTED WITH EXCITING AREAS OF 2322 01:39:36,200 --> 01:39:44,520 ACTIVITY AND WE HAVE PROGRAMS 2323 01:39:44,520 --> 01:39:46,720 FOR WOMEN IN SCIENCES AND TAKE 2324 01:39:46,720 --> 01:39:48,120 YOUR CHILD TO WORKDAY AT NIH AND 2325 01:39:48,120 --> 01:39:50,000 SOMETIMES THE TOUR IS THE 2326 01:39:50,000 --> 01:39:57,000 BIGGEST HIT OF THAT. 2327 01:39:57,000 --> 01:39:59,080 HOW DO EXPAND THAT IN RURAL 2328 01:39:59,080 --> 01:40:03,120 COMMUNITIES AND INTERSECT WITH 2329 01:40:03,120 --> 01:40:04,720 PEOPLE WHO AREN'T NECESSARILY IN 2330 01:40:04,720 --> 01:40:06,800 THE AREA AND BRING THIS TO THEM 2331 01:40:06,800 --> 01:40:08,880 IN A WAY THAT'S MEANINGFUL. 2332 01:40:08,880 --> 01:40:10,200 I THINK YOU'RE RIGHT. 2333 01:40:10,200 --> 01:40:13,320 BRAIN STORMING ABOUT THAT WOULD 2334 01:40:13,320 --> 01:40:13,640 BE GREAT. 2335 01:40:13,640 --> 01:40:15,920 AND THEN THE IDEA OF UPDATING 2336 01:40:15,920 --> 01:40:18,680 AND REPURPOSING THE RESOURCES I 2337 01:40:18,680 --> 01:40:19,440 THINK IS ANOTHER AREA. 2338 01:40:19,440 --> 01:40:23,120 WE DON'T WANT TO STOP AND SAY 2339 01:40:23,120 --> 01:40:24,920 WE'RE ALREADY DOING THAT OF 2340 01:40:24,920 --> 01:40:26,000 COURSE DURING THE ROUNDTABLES 2341 01:40:26,000 --> 01:40:26,760 BECAUSE MAYBE PEOPLE DON'T KNOW 2342 01:40:26,760 --> 01:40:28,680 SOME OF THEM BUT THE IDEA IS HOW 2343 01:40:28,680 --> 01:40:30,160 CAN WE MAKE THAT MORE EASY FOR 2344 01:40:30,160 --> 01:40:31,760 THEM TO GO TO A CENTRAL LOCATION 2345 01:40:31,760 --> 01:40:33,800 TO FIND OUT MORE ABOUT THE 2346 01:40:33,800 --> 01:40:35,120 RESOURCES AND HAVE THEM BE IN A 2347 01:40:35,120 --> 01:40:36,760 WAY THEY CAN USE THEM? 2348 01:40:36,760 --> 01:40:38,760 I THINK WE HAVE ALL OF THE 2349 01:40:38,760 --> 01:40:41,840 THINGS IN PLACE BUT WE NEED TO 2350 01:40:41,840 --> 01:40:43,160 TAKE ANOTHER LOOK AT THIS AS 2351 01:40:43,160 --> 01:40:43,360 WELL. 2352 01:40:43,360 --> 01:40:46,360 I THINK THAT'S A GREAT POINT. 2353 01:40:46,360 --> 01:40:48,320 THANK YOU, ANNIE FOR THE 2354 01:40:48,320 --> 01:40:48,600 COMMENTS. 2355 01:40:48,600 --> 01:40:51,000 GREAT TO SEE YOU. 2356 01:40:51,000 --> 01:40:57,200 SERGIO AND THEN MATTIAS. 2357 01:40:57,200 --> 01:41:02,680 >>THANK YOU. 2358 01:41:02,680 --> 01:41:08,920 I WANT TO THANK YOU, JONI, AND 2359 01:41:08,920 --> 01:41:11,120 OTHERS TO USE AN HOUR OF THE 2360 01:41:11,120 --> 01:41:13,000 COUNCIL MEETING TO TAKE A DEEP 2361 01:41:13,000 --> 01:41:13,200 DIVE. 2362 01:41:13,200 --> 01:41:15,840 I APPLAUD THE EFFORT AND AS I 2363 01:41:15,840 --> 01:41:18,400 SAID PREVIOUSLY, THE LISTENING 2364 01:41:18,400 --> 01:41:20,040 TOURS THAT YOU ARE TALKING ABOUT 2365 01:41:20,040 --> 01:41:21,480 I THINK IT'S SO IMPORTANT TO 2366 01:41:21,480 --> 01:41:26,920 HAVE A FINGER ON THE PULSE WITH 2367 01:41:26,920 --> 01:41:28,720 THE PUBLIC AND DIFFERENT 2368 01:41:28,720 --> 01:41:31,120 STAKEHOLDERS. 2369 01:41:31,120 --> 01:41:35,360 I APPRECIATE THAT VERY MUCH. 2370 01:41:35,360 --> 01:41:37,960 I ALSO PARTICIPATED IN ONE OF 2371 01:41:37,960 --> 01:41:43,120 THE ROUNDTABLES AND SPECIFICALLY 2372 01:41:43,120 --> 01:41:48,840 IN THE DEIA BREAKOUT AND THE 2373 01:41:48,840 --> 01:41:54,000 COMMUNITY ENGAGEMENT I THINK YOU 2374 01:41:54,000 --> 01:41:57,760 DID A GOOD JOB SUMMARIZING WHAT 2375 01:41:57,760 --> 01:42:00,640 TRANSPIRED AND THE MULTIPLE 2376 01:42:00,640 --> 01:42:00,920 COMMENTS. 2377 01:42:00,920 --> 01:42:05,880 THERE'S THINGS I WANT TO 2378 01:42:05,880 --> 01:42:06,160 EMPHASIZE. 2379 01:42:06,160 --> 01:42:11,120 ONE IS RELATED TO THE DIVISION 2380 01:42:11,120 --> 01:42:11,760 YOU MENTIONED. 2381 01:42:11,760 --> 01:42:14,200 IT'S VERY GOOD BY THE WAY, MORE 2382 01:42:14,200 --> 01:42:19,360 TREATMENTS TO ALL PEOPLE MORE 2383 01:42:19,360 --> 01:42:19,600 QUICKLY. 2384 01:42:19,600 --> 01:42:23,120 AND IN TERMS OF THE OLD PEOPLE, 2385 01:42:23,120 --> 01:42:27,680 ONE OF THE THINGS THAT WAS 2386 01:42:27,680 --> 01:42:30,520 DISCUSSED AND DIDN'T RISE LIKE 2387 01:42:30,520 --> 01:42:33,760 BUILDING TRUST AND BECOMING 2388 01:42:33,760 --> 01:42:34,200 TRUSTWORTHY. 2389 01:42:34,200 --> 01:42:37,280 BECOMING A TRUSTWORTHY 2390 01:42:37,280 --> 01:42:42,720 ORGANIZATION IN WHICH OLD PEOPLE 2391 01:42:42,720 --> 01:42:44,960 ESPECIALLY THOSE WOULD HAVE BEEN 2392 01:42:44,960 --> 01:42:47,400 UNDER SERVED OR LIVE IN THE 2393 01:42:47,400 --> 01:42:50,480 RURAL AREAS THAT USUALLY DON'T 2394 01:42:50,480 --> 01:42:55,120 BENEFIT FROM THE GOOD THIS GROUP 2395 01:42:55,120 --> 01:42:58,800 AND THE ORGANIZATION DOES. 2396 01:42:58,800 --> 01:43:00,760 I WOULD INVITE YOU TO REALLY 2397 01:43:00,760 --> 01:43:05,520 THINK THAT THROUGH. 2398 01:43:05,520 --> 01:43:16,080 THERE'S A TREMENDOUS BRIDGE WITH 2399 01:43:23,720 --> 01:43:25,560 NCATS AND GETTING THE WORK TO 2400 01:43:25,560 --> 01:43:30,640 MORE PEOPLE MORE QUICKLY. 2401 01:43:30,640 --> 01:43:39,760 THE AND WE CONTINUE TO THINK 2402 01:43:39,760 --> 01:43:43,120 THAT TREATMENTS ARE GOING TO 2403 01:43:43,120 --> 01:43:46,800 BE -- PEOPLE ARE GOING ACCESS 2404 01:43:46,800 --> 01:43:48,160 TREATMENT COMING TO WHERE THE 2405 01:43:48,160 --> 01:43:49,600 TREATMENTS ARE. 2406 01:43:49,600 --> 01:43:51,840 I CALL THAT THE WAITING MODE. 2407 01:43:51,840 --> 01:43:52,160 HERE WE ARE. 2408 01:43:52,160 --> 01:43:59,480 YOU CAME TO US. 2409 01:43:59,480 --> 01:44:01,680 INSTITUTIONAL BARRIERS AND 2410 01:44:01,680 --> 01:44:02,640 STRUCTURAL BARRIERS AND 2411 01:44:02,640 --> 01:44:05,560 PERCEPTUAL BARRIERS ESPECIALLY 2412 01:44:05,560 --> 01:44:10,800 HISTORICALLY UNDER SERVED 2413 01:44:10,800 --> 01:44:12,280 COMMUNITIES HAVE SO I THINK IT'S 2414 01:44:12,280 --> 01:44:17,320 TIME WE START THINKING ABOUT 2415 01:44:17,320 --> 01:44:20,000 MORE ABOUT THIS AND I THINK IT'S 2416 01:44:20,000 --> 01:44:22,920 IMPORTANT TO CONSIDER THE HEALTH 2417 01:44:22,920 --> 01:44:25,600 SERVICES FOR EXAMPLE THAT IN 2418 01:44:25,600 --> 01:44:28,160 THOSE TREATMENTS THAT ARE BEING 2419 01:44:28,160 --> 01:44:30,760 DEVELOPED MORE QUICKLY THAT CAN 2420 01:44:30,760 --> 01:44:34,680 BE PROVIDED IN A MORE EFFECTIVE 2421 01:44:34,680 --> 01:44:38,080 MANNER OVER TIME WITH AREAS OF 2422 01:44:38,080 --> 01:44:40,720 ACCESS TO SERVICES AND I HAVEN'T 2423 01:44:40,720 --> 01:44:43,120 SEEN THAT IN THE SUMMARY THAT 2424 01:44:43,120 --> 01:44:45,280 YOU MENTIONED. 2425 01:44:45,280 --> 01:44:46,200 AND THAT WAS DISCUSSED IN THE 2426 01:44:46,200 --> 01:44:51,840 BREAKOUTS THAT WE HAVE. 2427 01:44:51,840 --> 01:44:58,360 SO THIS IS JUST A REMINDER THAT 2428 01:44:58,360 --> 01:44:59,920 WAS DISCUSSED AND I HOPE IT 2429 01:44:59,920 --> 01:45:00,400 MAKES IT. 2430 01:45:00,400 --> 01:45:02,000 THE OTHER PIECE IS MENTAL 2431 01:45:02,000 --> 01:45:04,280 HEALTH. 2432 01:45:04,280 --> 01:45:06,240 MENTAL HEALTH IS USUALLY -- NOT 2433 01:45:06,240 --> 01:45:11,800 PUBLIC HEALTH. 2434 01:45:11,800 --> 01:45:15,840 I THINK THAT GETS LOST AND MORE 2435 01:45:15,840 --> 01:45:20,800 THAN EVER WE OUGHT TO BE 2436 01:45:20,800 --> 01:45:21,400 FOCUSSING MORE ATTENTION TO 2437 01:45:21,400 --> 01:45:29,000 MENTAL HEALTH. 2438 01:45:29,000 --> 01:45:39,400 AND FOCUSSING ON YOUTH AS WELL. 2439 01:45:39,400 --> 01:45:44,000 WE CAN COME UP WITH WAYS TO 2440 01:45:44,000 --> 01:45:47,120 ENGAGE IN THE PROCESS AS EARLY 2441 01:45:47,120 --> 01:45:49,680 AS POSSIBLE WILL SERVE AS WELL 2442 01:45:49,680 --> 01:46:00,240 AND IS GOING TO -- I ANTICIPATE 2443 01:46:01,080 --> 01:46:02,960 IT WILL WORK WITH THE VISION YOU 2444 01:46:02,960 --> 01:46:07,280 HAVE SHARED WITH US. 2445 01:46:07,280 --> 01:46:07,520 BRAVO. 2446 01:46:07,520 --> 01:46:11,360 IT'S GREAT YOU ARE LEADING THE 2447 01:46:11,360 --> 01:46:11,600 EFFORT. 2448 01:46:11,600 --> 01:46:14,640 I HAVEN'T SEEN THIS IN OTHER 2449 01:46:14,640 --> 01:46:16,000 INSTITUTES FRANKLY OR AGENCIES. 2450 01:46:16,000 --> 01:46:19,120 THIS IS PERHAPS UNIQUE. 2451 01:46:19,120 --> 01:46:20,840 I DON'T KNOW THE WHOLE LANDSCAPE 2452 01:46:20,840 --> 01:46:26,880 BUT THIS IS THE FIRST TIME I 2453 01:46:26,880 --> 01:46:27,520 HAVE SEEN THE ROUNDTABLE 2454 01:46:27,520 --> 01:46:31,120 LISTENING SESSIONS. 2455 01:46:31,120 --> 01:46:34,800 THAT'S GREAT. 2456 01:46:34,800 --> 01:46:36,240 >>THANK YOU, SERGIO. 2457 01:46:36,240 --> 01:46:37,640 I APPRECIATE THE IDEA OF THE 2458 01:46:37,640 --> 01:46:39,680 FACT THAT BUILDING TRUST DOES 2459 01:46:39,680 --> 01:46:46,160 NOT EQUAL TRUSTWORTHINESS. 2460 01:46:46,160 --> 01:46:48,760 IT'S AN IMPORTANT DISTINCTION. 2461 01:46:48,760 --> 01:46:51,120 ONE IS NECESSARY BUT NOT 2462 01:46:51,120 --> 01:46:58,160 SUFFICIENT TO HAVE THE OTHER. 2463 01:46:58,160 --> 01:47:03,480 AND WITH ALL THE COMMENTS PEOPLE 2464 01:47:03,480 --> 01:47:05,920 HAVE MADE GOES TO HOW NCATS CAN 2465 01:47:05,920 --> 01:47:08,000 BE MORE TRUSTWORTHY. 2466 01:47:08,000 --> 01:47:18,520 I APPRECIATE THE AMALGAMATION 2467 01:47:20,040 --> 01:47:22,960 AND WITH COST AND ACCESS THERE 2468 01:47:22,960 --> 01:47:25,800 ARE SOME THINGS WE CAN DO AND 2469 01:47:25,800 --> 01:47:27,120 SOME THINGS WE SHOULD RESEARCH 2470 01:47:27,120 --> 01:47:27,400 MORE. 2471 01:47:27,400 --> 01:47:28,360 THERE ARE RESEARCH QUESTIONS WE 2472 01:47:28,360 --> 01:47:30,440 COULD BE THINKING ABOUT AND 2473 01:47:30,440 --> 01:47:31,760 BUILDING THEM INTO THE FABRIC 2474 01:47:31,760 --> 01:47:37,000 AND WHAT THOSE ARE I'M NOT SURE. 2475 01:47:37,000 --> 01:47:39,000 THESE ARE AREAS WE NEED TO START 2476 01:47:39,000 --> 01:47:40,760 TO EXPLORE MORE IN DEPTH AND 2477 01:47:40,760 --> 01:47:45,920 WITH THAT PERHAPS WE CAN START 2478 01:47:45,920 --> 01:47:47,160 TO GET AT INTERESTED YOUNG 2479 01:47:47,160 --> 01:47:52,440 PEOPLE AND FOLKS WHO ARE GOING 2480 01:47:52,440 --> 01:47:56,640 TO BE ABLE TO USE THAT 2481 01:47:56,640 --> 01:47:58,760 ENTHUSIASM IN AREAS LIKE MENTAL 2482 01:47:58,760 --> 01:48:00,280 HEALTH AND OTHER AREAS. 2483 01:48:00,280 --> 01:48:05,680 YOU MAY THINK MENTAL HEALTH IS 2484 01:48:05,680 --> 01:48:16,200 NOT IT BUT THERE'S A NEED IN THE 2485 01:48:16,560 --> 01:48:19,360 SPACE AND THE NEXT QUESTION IS 2486 01:48:19,360 --> 01:48:21,480 HOW WE PRIORITIZE ABOUT THIS. 2487 01:48:21,480 --> 01:48:23,200 THINK ABOUT THAT. 2488 01:48:23,200 --> 01:48:25,920 BEFORE WE GO THERE I WANT TO GO 2489 01:48:25,920 --> 01:48:27,120 TO MATTIAS WHO HAS BEEN WAITING 2490 01:48:27,120 --> 01:48:35,080 PATIENTLY. 2491 01:48:35,080 --> 01:48:42,920 >>I HAVEN'T SEEN THAT AND YOU 2492 01:48:42,920 --> 01:48:45,000 MAY REMEMBER AT THE LAST COUNCIL 2493 01:48:45,000 --> 01:48:47,800 MEETING WE DISCUSSED THE 2494 01:48:47,800 --> 01:48:50,920 CHALLENGE AND THE ADVANTAGE CTSA 2495 01:48:50,920 --> 01:48:53,560 DID NOT REACH THE PATIENT. 2496 01:48:53,560 --> 01:48:59,680 WE SHOWED A SAD EXAMPLE THIS 2497 01:48:59,680 --> 01:48:59,960 AFTERNOON. 2498 01:48:59,960 --> 01:49:03,120 SO YES, PLEASE FOCUS AND ONE 2499 01:49:03,120 --> 01:49:08,840 STORY I LEARN FROM AND YES WE 2500 01:49:08,840 --> 01:49:12,240 MANAGED NCATS WITH THE 2501 01:49:12,240 --> 01:49:16,360 RELATIONSHIPS BETWEEN PATIENT 2502 01:49:16,360 --> 01:49:18,880 ORGANIZATIONS AND NCATS AND 2503 01:49:18,880 --> 01:49:20,800 THERE IS ONE MODEL FOR APPROACH 2504 01:49:20,800 --> 01:49:21,320 TO IT. 2505 01:49:21,320 --> 01:49:23,880 AND THE MEETING I STEPPED OUT IS 2506 01:49:23,880 --> 01:49:31,120 DOING THAT AND KIDNEY DISEASE 2507 01:49:31,120 --> 01:49:39,840 AND INSURANCE COMPANIES ARE 2508 01:49:39,840 --> 01:49:43,880 CHANGING THEIR ROLE AS WE SPEAK. 2509 01:49:43,880 --> 01:49:45,680 THEY ARE HEADED INTO 2510 01:49:45,680 --> 01:49:50,480 IMPLEMENTATION SCIENCE TO REDUCE 2511 01:49:50,480 --> 01:49:52,800 COST AND IN THE PAST THE MODEL 2512 01:49:52,800 --> 01:49:56,000 BETWEEN CARE PROVISION AND 2513 01:49:56,000 --> 01:49:57,360 INSURANCE IS NOT SUFFICIENT OF 2514 01:49:57,360 --> 01:50:00,360 THE FUTURE AS BUILDING OUT THE 2515 01:50:00,360 --> 01:50:03,120 RESEARCH INFRASTRUCTURE WE CAN 2516 01:50:03,120 --> 01:50:04,800 INTERSECT WITH THE HUGE 2517 01:50:04,800 --> 01:50:06,320 DATABASES AVAILABLE AND BRING 2518 01:50:06,320 --> 01:50:07,720 THEM TOGETHER WITH OUR RESEARCH 2519 01:50:07,720 --> 01:50:09,640 EFFORTS I THINK IS A SIGNIFICANT 2520 01:50:09,640 --> 01:50:12,040 OPPORTUNITY AND AGAIN CAN 2521 01:50:12,040 --> 01:50:17,240 HOPEFULLY BUILD TRUST BACK INTO 2522 01:50:17,240 --> 01:50:19,480 A SYSTEM AND THE FINAL POINT 2523 01:50:19,480 --> 01:50:23,920 SPEAKING WITH A GERMAN ACCIDENT, 2524 01:50:23,920 --> 01:50:28,920 YES, NCAT HAS IMPACT AND 2525 01:50:28,920 --> 01:50:31,440 CLAWABLE EFFORTS CAN BE 2526 01:50:31,440 --> 01:50:34,920 LEVERAGED FOR INVESTMENT OF TAX 2527 01:50:34,920 --> 01:50:36,880 DOLLARS FOR US HERE. 2528 01:50:36,880 --> 01:50:41,800 I HAVE NOT SEEN IN THE OUTREACH 2529 01:50:41,800 --> 01:50:46,640 EFFORT ANY EFFORTS TO ENGAGE AND 2530 01:50:46,640 --> 01:50:50,000 THERE'S AN EXAMPLE HOW NCATS IS 2531 01:50:50,000 --> 01:50:53,080 IMPACTING THE RARE DISEASE 2532 01:50:53,080 --> 01:50:54,880 GLOBAL COMMUNITY AND HAS TAUGHT 2533 01:50:54,880 --> 01:50:56,800 THE COMMUNITY A LOT AND THINKING 2534 01:50:56,800 --> 01:51:03,120 OF WAYS HOW TO MAKE SURE THAT 2535 01:51:03,120 --> 01:51:05,240 THAT OPPORTUNITY IS NOT LOST. 2536 01:51:05,240 --> 01:51:10,800 THANKS SO MUCH FOR ALL YOU DO. 2537 01:51:10,800 --> 01:51:13,880 >>THANK YOU SO MUCH. 2538 01:51:13,880 --> 01:51:15,280 IS THAT WAS GREAT. 2539 01:51:15,280 --> 01:51:16,720 THIS IS MY BAD. 2540 01:51:16,720 --> 01:51:19,000 ONE THING I DIDN'T MENTION IN 2541 01:51:19,000 --> 01:51:19,640 TERMS OF THE EFFORTS IN THE MORE 2542 01:51:19,640 --> 01:51:24,360 INTERNATIONAL SPACING. 2543 01:51:24,360 --> 01:51:26,800 "HAVE HAD AN OPPORTUNITY TO 2544 01:51:26,800 --> 01:51:34,200 INTERACT WITH SOME OF THE 2545 01:51:34,200 --> 01:51:37,280 EMBASSIES IN D.C. AND THE 2546 01:51:37,280 --> 01:51:37,920 ATTACHES IN THE SCIENTIFIC 2547 01:51:37,920 --> 01:51:38,720 COMMUNITY AND EMBASSIES. 2548 01:51:38,720 --> 01:51:40,280 I'LL BE SPEAKING WITH THEM AT 2549 01:51:40,280 --> 01:51:46,880 THE SCIENCE DIPLOMAT COUNCIL IN 2550 01:51:46,880 --> 01:51:48,520 THE NEXT MONTH AND LOOK FORWARD 2551 01:51:48,520 --> 01:51:49,680 TO THOSE CONVERSATIONS AND 2552 01:51:49,680 --> 01:51:52,040 BRINGING UP THESE KINDS OF IDEAS 2553 01:51:52,040 --> 01:51:54,320 IN THE RARE DISEASE SPACE FOR 2554 01:51:54,320 --> 01:51:55,880 EXAMPLE WHERE WE HAVE AN 2555 01:51:55,880 --> 01:51:56,680 OPPORTUNITY TO LEVEL THE ABILITY 2556 01:51:56,680 --> 01:52:03,120 AND BRING IN MORE OF THE RARE 2557 01:52:03,120 --> 01:52:07,480 DISEASE PATIENTS WHO ARE CRASS 2558 01:52:07,480 --> 01:52:10,560 THE GLOBE AND MAXIMIZING OUR 2559 01:52:10,560 --> 01:52:12,840 ABILITY TO REACH THE PATIENTS IN 2560 01:52:12,840 --> 01:52:13,960 THE RARE DISEASE SPACE WHEN IT'S 2561 01:52:13,960 --> 01:52:24,360 SO CRITICAL WE DO SO. 2562 01:52:32,680 --> 01:52:35,520 WE HAVE PJ BROOKS AS A MEMBER 2563 01:52:35,520 --> 01:52:36,720 AND I SHOULD ALSO MENTION YOU'LL 2564 01:52:36,720 --> 01:52:40,280 PROBABLY HEAR MORE ABOUT THIS IN 2565 01:52:40,280 --> 01:52:42,760 THE UPDATE IN THE DIVISION OF 2566 01:52:42,760 --> 01:52:43,680 RARE DISEASE RESEARCH 2567 01:52:43,680 --> 01:52:43,960 INNOVATIONS. 2568 01:52:43,960 --> 01:52:47,600 WE'LL TALK ABOUT THE RBCRN AND 2569 01:52:47,600 --> 01:52:49,560 PJ WILL TELL YOU MORE ABOUT WHAT 2570 01:52:49,560 --> 01:52:53,600 WE'RE DOING AND WE'LL TALK ABOUT 2571 01:52:53,600 --> 01:52:56,080 SOME OF THOSE IMPACTS BUT 2572 01:52:56,080 --> 01:52:57,320 THEY'RE MOBILE IMPACTS. 2573 01:52:57,320 --> 01:53:03,000 IT'S CRITICAL AND I'LL TRY TO 2574 01:53:03,000 --> 01:53:04,840 HIGHLIGHT THOSE A BIT MORE AND 2575 01:53:04,840 --> 01:53:09,840 IT'S A GOOD POINT. 2576 01:53:09,840 --> 01:53:16,640 PAUL AND THEN KEITH. 2577 01:53:16,640 --> 01:53:19,960 >>I LIKE THE FORMAT. 2578 01:53:19,960 --> 01:53:23,120 AND IT FELT LIKE THE PROGRAM WAS 2579 01:53:23,120 --> 01:53:30,600 LISTENING. 2580 01:53:30,600 --> 01:53:33,360 AND THERE WAS AN ANONYMOUS WAY 2581 01:53:33,360 --> 01:53:35,400 TO ANSWER AND AN IDENTIFIED CHAT 2582 01:53:35,400 --> 01:53:36,240 WINDOW. 2583 01:53:36,240 --> 01:53:37,840 I DON'T THINK PEOPLE WERE 2584 01:53:37,840 --> 01:53:39,160 NECESSARILY TRYING TO BE 2585 01:53:39,160 --> 01:53:40,840 ANONYMOUS BUT I THOUGHT IT WAS 2586 01:53:40,840 --> 01:53:42,560 NICE THEY WOULD HAVE THE OPTION 2587 01:53:42,560 --> 01:53:46,120 IF THEY WANTED. 2588 01:53:46,120 --> 01:53:49,160 GOING BACK TO ANDY KENNEDY'S 2589 01:53:49,160 --> 01:53:50,200 COMMENTS, I AGREE. 2590 01:53:50,200 --> 01:53:51,760 THE LISTENING SESSIONS ARE NOT 2591 01:53:51,760 --> 01:53:54,640 THE TIME TO SAY YOU DIDN'T KNOW 2592 01:53:54,640 --> 01:53:56,000 THIS EXISTED BUT IT WOULD BE 2593 01:53:56,000 --> 01:53:59,000 GREAT AS YOU WRAP UP THE 2594 01:53:59,000 --> 01:54:01,360 SESSIONS MAYBE PUTTING A 2595 01:54:01,360 --> 01:54:02,040 COMMUNICATION OUT ABOUT WHAT YOU 2596 01:54:02,040 --> 01:54:06,240 HEARD AND HOW TO USE THE 2597 01:54:06,240 --> 01:54:08,000 INFORMATION WOULD BE A GREAT 2598 01:54:08,000 --> 01:54:11,480 TIME TO HIGHLIGHT THINGS ALREADY 2599 01:54:11,480 --> 01:54:12,280 THERE. 2600 01:54:12,280 --> 01:54:15,520 OF THOSE THINK CONTINUOUS SMALL 2601 01:54:15,520 --> 01:54:16,640 COMMUNICATIONS WOULD BE A GREAT 2602 01:54:16,640 --> 01:54:18,680 WAY TO KEEP FRONT AND CENTER AND 2603 01:54:18,680 --> 01:54:21,480 IN PEOPLE'S MINDS AS DIFFERENT 2604 01:54:21,480 --> 01:54:23,120 ASPECTS OF THE NCATS PROGRAM AT 2605 01:54:23,120 --> 01:54:33,200 LARGE. 2606 01:54:42,000 --> 01:54:47,400 >>I AGREE KEEPING THE 2607 01:54:47,400 --> 01:54:48,360 COMMUNICATION PIECE OPEN AND 2608 01:54:48,360 --> 01:54:50,000 GOING FORWARD AND TALKING ABOUT 2609 01:54:50,000 --> 01:54:51,760 THE SUCCESSES AND PERHAPS EVEN 2610 01:54:51,760 --> 01:54:54,560 WHAT'S NOT WORKING WELL AND THAT 2611 01:54:54,560 --> 01:54:56,000 DISSEMINATION PIECE OF EVEN THAT 2612 01:54:56,000 --> 01:55:04,760 I THINK WILL BE INTERESTING. 2613 01:55:04,760 --> 01:55:07,880 WE'VE TALKED ABOUT THIS A BIT 2614 01:55:07,880 --> 01:55:11,040 AND WITH THE AMPLIFICATION OF 2615 01:55:11,040 --> 01:55:12,680 WHAT YOU SAID AND INTERNALLY IT 2616 01:55:12,680 --> 01:55:13,720 TELLS US IT'S PROBABLY A 2617 01:55:13,720 --> 01:55:15,080 DIRECTION WE CAN TRY TO MOVE IN. 2618 01:55:15,080 --> 01:55:21,720 UP IN 2619 01:55:21,720 --> 01:55:26,600 >>AS I THINK ABOUT COMMUNITY 2620 01:55:26,600 --> 01:55:28,760 ENGAGEMENT AND ENGAGEMENT OF 2621 01:55:28,760 --> 01:55:29,000 PATIENTS. 2622 01:55:29,000 --> 01:55:31,120 A PARALLEL STRIKES ME FROM THE 2623 01:55:31,120 --> 01:55:33,600 TOUR TODAY WHEN WE SAW THE 2624 01:55:33,600 --> 01:55:37,000 DEMONSTRATION OF TRYING TO MOVE 2625 01:55:37,000 --> 01:55:38,880 FROM THE EXPERIMENTS THAT DON'T 2626 01:55:38,880 --> 01:55:44,960 ENGAGE PATIENTS DIRECTLY BUT 2627 01:55:44,960 --> 01:55:46,440 MAYBE IN THE CLINICAL TRIAL 2628 01:55:46,440 --> 01:55:49,120 SPACE AND TO THE FIELD AND THE 2629 01:55:49,120 --> 01:55:51,920 INFUSION OF THE CELL INTO MUSCLE 2630 01:55:51,920 --> 01:55:53,600 OR SKIN TISSUE TO SEE WHAT'S THE 2631 01:55:53,600 --> 01:55:54,520 REAL WORLD IMPACT. 2632 01:55:54,520 --> 01:55:57,040 I THINK ABOUT THE SAME THING 2633 01:55:57,040 --> 01:55:59,040 WHEN IT COMES TO DISSEMINATION 2634 01:55:59,040 --> 01:56:02,040 AND TRYING TO ACHIEVE AGAIN THE 2635 01:56:02,040 --> 01:56:03,760 VISION TREATMENT FOR ALL PEOPLE 2636 01:56:03,760 --> 01:56:05,440 MORE QUICKLY. 2637 01:56:05,440 --> 01:56:10,320 HOW DO YOU GET TO THE COMMUNITY 2638 01:56:10,320 --> 01:56:12,440 LEVEL NOT EVEN JUST THE 2639 01:56:12,440 --> 01:56:14,000 CLINICIANS BUT INTO THE ENTIRE 2640 01:56:14,000 --> 01:56:16,440 COMMUNITY. 2641 01:56:16,440 --> 01:56:18,840 I THINK OF TWO SPECIFIC EXAMPLES 2642 01:56:18,840 --> 01:56:21,280 TO DO THAT. 2643 01:56:21,280 --> 01:56:24,000 ONE IS FOR DIRECTED ENGAGEMENT 2644 01:56:24,000 --> 01:56:26,000 OF THE SOCIAL SCIENTISTS WHO 2645 01:56:26,000 --> 01:56:28,960 UNDERSTAND THAT DYNAMIC MORE AND 2646 01:56:28,960 --> 01:56:32,880 THE CTSA PROVIDE AN EXCELLENT 2647 01:56:32,880 --> 01:56:34,360 PLATFORM FOR DOING IT AND THE 2648 01:56:34,360 --> 01:56:36,960 OTHER IS PLAYING OFF THE 2649 01:56:36,960 --> 01:56:38,320 TELEHEALTH DISSEMINATION IDEA 2650 01:56:38,320 --> 01:56:41,400 BECAUSE WE WORK ON THAT AND THE 2651 01:56:41,400 --> 01:56:43,080 PANEL I SHARED AND I JOTTED DOWN 2652 01:56:43,080 --> 01:56:44,920 A COUPLE EXAMPLES WHY IT'S 2653 01:56:44,920 --> 01:56:46,840 IMPORTANT TO UNDERSTAND THE END 2654 01:56:46,840 --> 01:56:49,720 POINT AS BEST YOU CAN. 2655 01:56:49,720 --> 01:56:51,520 ONE IS IS IT EVEN AVAILABLE. 2656 01:56:51,520 --> 01:56:54,600 WE'RE STILL TRYING TO EXPAND THE 2657 01:56:54,600 --> 01:56:55,560 ACCESS TO BROADBAND TECHNOLOGY 2658 01:56:55,560 --> 01:56:58,960 IN A WAY IF WE START THINKING 2659 01:56:58,960 --> 01:56:59,920 ABOUT DIGITAL TECHNOLOGY IN THE 2660 01:56:59,920 --> 01:57:02,000 HOME THERE'S A LARGE PERCENTAGE 2661 01:57:02,000 --> 01:57:03,200 OF AMERICA WHERE THAT'S NOT 2662 01:57:03,200 --> 01:57:06,360 POSSIBLE YET AND THE SECOND ONE 2663 01:57:06,360 --> 01:57:09,560 I'VE ONLY MORE RECENTLY BEGAN TO 2664 01:57:09,560 --> 01:57:11,960 THINK ABOUT MORE CAREFULLY IS 2665 01:57:11,960 --> 01:57:12,360 DIGITAL LITERACY. 2666 01:57:12,360 --> 01:57:15,120 IF YOU TRY TO APPROACH A 2667 01:57:15,120 --> 01:57:20,000 POPULATION THAT IS BEHIND THE 2668 01:57:20,000 --> 01:57:23,600 TIMES AND THE AGE COHORT MANY 2669 01:57:23,600 --> 01:57:25,120 COLLEAGUES AND I ARE IN AND SAW 2670 01:57:25,120 --> 01:57:27,720 A GOOD CASE STUDY OF THIS AT THE 2671 01:57:27,720 --> 01:57:28,440 NATIONAL HEALTH ASSOCIATION LAST 2672 01:57:28,440 --> 01:57:33,480 WEEK A PROJECT IN MINNESOTA 2673 01:57:33,480 --> 01:57:36,440 CALLED REACH WHERE THEY'RE 2674 01:57:36,440 --> 01:57:36,960 REACHING INTO THE LOCAL 2675 01:57:36,960 --> 01:57:38,080 COMMUNITIES THROUGH THE LIBRARY 2676 01:57:38,080 --> 01:57:41,680 TO HELP THE ELDERLY POPULATIONS 2677 01:57:41,680 --> 01:57:43,120 WITH DIGITAL LITERACY AS WELL AS 2678 01:57:43,120 --> 01:57:44,840 ACCESS TO BROADBAND. 2679 01:57:44,840 --> 01:57:46,920 THAT'S THE INNOVATION ON THE 2680 01:57:46,920 --> 01:57:49,360 SOCIAL SIDE THAT WOULD HELP 2681 01:57:49,360 --> 01:57:52,160 NCATS AND OTHERS MOVE THE 2682 01:57:52,160 --> 01:57:54,440 CLINICAL DEVELOPMENT TO THE 2683 01:57:54,440 --> 01:57:55,200 PATIENT AND A BROADER CROSS 2684 01:57:55,200 --> 01:58:05,520 SECTION OF PATIENTS. 2685 01:58:07,080 --> 01:58:13,280 >>KEITH, AND GOING BACK TO 2686 01:58:13,280 --> 01:58:15,120 SERGIO WHEN I SHOWED THE PIECE 2687 01:58:15,120 --> 01:58:17,040 ON THE COMMUNITY ADVISORY BOARD 2688 01:58:17,040 --> 01:58:19,480 MEMBER IN THIS PARTICULAR 2689 01:58:19,480 --> 01:58:20,680 PROJECT WITH THE NATIONAL 2690 01:58:20,680 --> 01:58:25,400 ACADEMIES THE IDEA OF THE SOCIAL 2691 01:58:25,400 --> 01:58:30,440 PIECE THE SOCIAL COMMUNITY 2692 01:58:30,440 --> 01:58:34,600 ENGAGEMENT WHAT SHE FOUND WAS 2693 01:58:34,600 --> 01:58:37,040 GOING INTO INTO THAT SCENARIO 2694 01:58:37,040 --> 01:58:40,920 SHE HAD A PRECONCEPTION BUT 2695 01:58:40,920 --> 01:58:46,240 AFTER ENGAGEMENT FIRST IT'S NOT 2696 01:58:46,240 --> 01:58:49,280 THE ROOT SHE TALKS ABOUT HER 2697 01:58:49,280 --> 01:58:53,360 ABILITY TO PIVOT TO WHAT THE 2698 01:58:53,360 --> 01:58:56,000 ROOT OF THE PROBLEMS AND WHEN 2699 01:58:56,000 --> 01:58:59,080 YOU TALK ABOUT ENGAGING SOCIAL 2700 01:58:59,080 --> 01:59:00,440 SCIENTISTS TO THINK OF THAT 2701 01:59:00,440 --> 01:59:01,920 ENGAGEMENT AT THE COMMUNITY 2702 01:59:01,920 --> 01:59:04,560 LEVEL OFTEN WE THINK ABOUT THAT 2703 01:59:04,560 --> 01:59:07,240 AS BEING UNTANGIBLE OR HARD TO 2704 01:59:07,240 --> 01:59:08,080 DO, DIFFICULT. 2705 01:59:08,080 --> 01:59:09,120 IT'S NOT SOMETHING WE KNOW A LOT 2706 01:59:09,120 --> 01:59:11,800 ABOUT HOW TO DO BUT THE SOCIAL 2707 01:59:11,800 --> 01:59:16,560 SCIENTIST ENGAGING THEM AND THE 2708 01:59:16,560 --> 01:59:17,160 IMPORTANCE OF DISSEMINATING 2709 01:59:17,160 --> 01:59:22,360 CRITICAL WORK WE'RE DOING AND 2710 01:59:22,360 --> 01:59:30,040 MAKING PEOPLE AWARE HOW TO START 2711 01:59:30,040 --> 01:59:31,720 THROUGH THE HEALTH LITERACY 2712 01:59:31,720 --> 01:59:37,360 PROGRAMS AND I WAS STRUCK ABOUT 2713 01:59:37,360 --> 01:59:42,800 THE VIDEO I SHOWED IS THE 2714 01:59:42,800 --> 01:59:44,800 SOLUTIONS AREN'T OFTEN THAT 2715 01:59:44,800 --> 01:59:45,440 CHALLENGING BUT WE DON'T TAKE 2716 01:59:45,440 --> 01:59:54,080 THE TIME TO UNDERSTAND THEM. 2717 01:59:54,080 --> 01:59:56,360 AND IN THE ENVIRONMENTS IS WHERE 2718 01:59:56,360 --> 01:59:58,880 THE MAGIC CAN HAPPEN. 2719 01:59:58,880 --> 02:00:02,280 WHAT YOU'RE SPEAKING TO IS THE 2720 02:00:02,280 --> 02:00:09,640 IDEA OF HOW TO ENGAGE THAT PIECE 2721 02:00:09,640 --> 02:00:11,000 AND GET INTO THE SOCIAL 2722 02:00:11,000 --> 02:00:15,080 CONSTRUCT OF WHAT WE'RE TALKING 2723 02:00:15,080 --> 02:00:16,520 ABOUT EVEN BETTER. 2724 02:00:16,520 --> 02:00:19,560 CERTAINLY TELEHEALTH AND 2725 02:00:19,560 --> 02:00:22,000 TELEMEDICINE IS USED AT A LEVEL 2726 02:00:22,000 --> 02:00:24,000 OF HEALTH CARE AND IN TERMS OF 2727 02:00:24,000 --> 02:00:26,000 HEALTH LITERACY AND DIGITAL 2728 02:00:26,000 --> 02:00:30,600 LITERACY THERE ARE LOTS OF 2729 02:00:30,600 --> 02:00:34,040 OPPORTUNITIES THERE WE HAVE A 2730 02:00:34,040 --> 02:00:35,760 PROGRAM AND CHRIS RUNS OUR 2731 02:00:35,760 --> 02:00:38,600 DIGITAL HEALTH ASPECTS AND SO I 2732 02:00:38,600 --> 02:00:39,920 THINK THIS WILL BE EXPECT THAT 2733 02:00:39,920 --> 02:00:41,680 WILL CONTINUE TO TALK ABOUT MORE 2734 02:00:41,680 --> 02:00:45,160 AND SO I APPRECIATE YOUR 2735 02:00:45,160 --> 02:00:46,920 COMMENTS ON THAT AND FIGURING 2736 02:00:46,920 --> 02:00:49,480 OUT HOW TO WORK WITH THE SOCIAL 2737 02:00:49,480 --> 02:00:50,440 SCIENTISTS TO GET MORE INSIGHT 2738 02:00:50,440 --> 02:00:51,160 INTO THAT. 2739 02:00:51,160 --> 02:00:55,120 THAT'S A GREAT IDEA. 2740 02:00:55,120 --> 02:00:58,200 THANK YOU. 2741 02:00:58,200 --> 02:01:01,560 I DON'T SEE ANY OTHER HANDS. 2742 02:01:01,560 --> 02:01:01,960 AM I MISSING ONE? 2743 02:01:01,960 --> 02:01:08,400 GO AHEAD. 2744 02:01:08,400 --> 02:01:14,160 >>I WANT TO SPRING BOARD ON THE 2745 02:01:14,160 --> 02:01:16,560 LAST DISCUSSION WITH THE 2746 02:01:16,560 --> 02:01:18,280 EXTENSION AGENTS AND USUALLY RUN 2747 02:01:18,280 --> 02:01:20,720 THROUGH THE LENS OF A UNIVERSITY 2748 02:01:20,720 --> 02:01:26,400 AND MY MOTHER WAS AN EXTENSION 2749 02:01:26,400 --> 02:01:27,800 AGENT AND THEY KNOW THE 2750 02:01:27,800 --> 02:01:29,000 COMMUNITY AND HAVE THE TRUST OF 2751 02:01:29,000 --> 02:01:33,160 THE PEOPLE IN THE COMMUNITY AND 2752 02:01:33,160 --> 02:01:35,240 WE'RE NOT EQUALLINGIZING THEM 2753 02:01:35,240 --> 02:01:37,760 FOR THIS KIND OF STUFF AND THEY 2754 02:01:37,760 --> 02:01:39,720 HAVE A FOOTPRINT IN EVERY 2755 02:01:39,720 --> 02:01:41,400 COUNTY. 2756 02:01:41,400 --> 02:01:43,400 OFTEN A LOT OF THEM IN THE 4H 2757 02:01:43,400 --> 02:01:48,120 PROGRAM AND RURAL COMMUNITIES. 2758 02:01:48,120 --> 02:01:49,360 AROUND MEDICINE HEALTH AND 2759 02:01:49,360 --> 02:01:51,440 SCIENTISTS IN YOUR LOCAL 2760 02:01:51,440 --> 02:01:54,480 COMMUNITY AND THE LEVELS THAT 2761 02:01:54,480 --> 02:01:56,280 CAN BE DONE TO ENGAGE BEFORE THE 2762 02:01:56,280 --> 02:01:57,280 10 YEARS OF AGE. 2763 02:01:57,280 --> 02:02:00,000 THESE ARE PROGRAMS THAT HAVE AN 2764 02:02:00,000 --> 02:02:02,520 INFRASTRUCTURE THAT WE JUST NEED 2765 02:02:02,520 --> 02:02:03,600 TO TAP INTO. 2766 02:02:03,600 --> 02:02:07,520 >>GREAT POINT. 2767 02:02:07,520 --> 02:02:09,600 AND MIKE IF YOU'RE STILL AT THE 2768 02:02:09,600 --> 02:02:10,920 TABLE MAYBE YOU CAN COMMENT ON 2769 02:02:10,920 --> 02:02:15,280 THIS AS WELL. 2770 02:02:15,280 --> 02:02:20,000 I'LL SAY THROUGH THIS WAS 2771 02:02:20,000 --> 02:02:22,240 PROBABLY PRE-PANDEMIC, I THINK, 2772 02:02:22,240 --> 02:02:28,000 BUT WE HAD THE IDEA OF THE 2773 02:02:28,000 --> 02:02:31,920 EXTENSION PROGRAM AND THINKING 2774 02:02:31,920 --> 02:02:33,280 OF WAYS TO ENGAGE AND THE MAY BE 2775 02:02:33,280 --> 02:02:35,160 TIME TO PICK UP ON THAT AGAIN. 2776 02:02:35,160 --> 02:02:37,400 I'M ALSO FROM A RURAL COMMUNITY 2777 02:02:37,400 --> 02:02:39,760 IN KANSAS AND GREW UP WITHIN 2778 02:02:39,760 --> 02:02:41,560 EXTENSION PROGRAMS. 2779 02:02:41,560 --> 02:02:46,440 WHEN I THINK ABOUT IT, I THINK 2780 02:02:46,440 --> 02:02:48,800 ABOUT IT IN THE AGRICULTURE 2781 02:02:48,800 --> 02:02:50,440 SECTION BUT THERE'S A LOT OF 2782 02:02:50,440 --> 02:02:51,760 WORK IN THE HEALTH SPACE TOO AND 2783 02:02:51,760 --> 02:02:57,000 HOW TO TAP IN MORE WOULD BE 2784 02:02:57,000 --> 02:02:57,320 GREAT. 2785 02:02:57,320 --> 02:03:02,720 THE OTHER POINT IS WE'VE BEEN 2786 02:03:02,720 --> 02:03:05,200 STARTING TO ENGAGE WITH HHRQ AND 2787 02:03:05,200 --> 02:03:10,360 THE HEALTH RESEARCH AND QUALITY 2788 02:03:10,360 --> 02:03:12,640 AND THINKING ABOUT AREAS WHERE 2789 02:03:12,640 --> 02:03:14,520 THEY'RE SUPPORTED IN THIS 2790 02:03:14,520 --> 02:03:15,280 SIMILAR VEIN AS WELL. 2791 02:03:15,280 --> 02:03:18,040 I WANTED TO HAVE YOU COMMENT ON 2792 02:03:18,040 --> 02:03:21,640 THE CTSA MEETING. 2793 02:03:21,640 --> 02:03:24,000 >>SO PRE-COVID WHICH I 2794 02:03:24,000 --> 02:03:28,760 RECOGNIZE WAS A LONG TIME AGO WE 2795 02:03:28,760 --> 02:03:33,320 HAD A MEETING ON RURAL HEALTH 2796 02:03:33,320 --> 02:03:35,560 AND THE TOPIC OF THE EXTENSION 2797 02:03:35,560 --> 02:03:37,080 SERVICE CAME UP BECAUSE MANY 2798 02:03:37,080 --> 02:03:38,440 ACTIVELY ENGAGE WITH THEM AND IT 2799 02:03:38,440 --> 02:03:40,440 WAS SURPRISING BECAUSE MANY WERE 2800 02:03:40,440 --> 02:03:43,120 TOTALLY UNAWARE OF THIS. 2801 02:03:43,120 --> 02:03:45,680 I HAD A COUPLE FOLLOW-UP 2802 02:03:45,680 --> 02:03:47,200 MEETINGS WITH OFFICIALS FROM THE 2803 02:03:47,200 --> 02:03:49,640 USDA AND INVITED ONE TO COME TO 2804 02:03:49,640 --> 02:03:51,160 OUR ANNUAL PROGRAM MEETING TO 2805 02:03:51,160 --> 02:03:52,360 MAKE THIS AVAILABLE. 2806 02:03:52,360 --> 02:03:54,240 TALK ABOUT IT. 2807 02:03:54,240 --> 02:03:58,000 I DON'T KNOW THE BARRIERS THAT 2808 02:03:58,000 --> 02:03:59,400 EXIST IN INDIVIDUAL STAKES THAT 2809 02:03:59,400 --> 02:04:01,040 MAY PRECLUDE THOSE INTERACTIONS 2810 02:04:01,040 --> 02:04:02,600 FROM OCCURRING. 2811 02:04:02,600 --> 02:04:04,640 WHEN THEY DO OCCUR WE HAVE MANY 2812 02:04:04,640 --> 02:04:06,880 EXAMPLES ACROSS THE CTSAs WHERE 2813 02:04:06,880 --> 02:04:10,520 THEY'VE BEEN PRODUCTIVE AND FROM 2814 02:04:10,520 --> 02:04:12,680 THE USDA PERSPECTIVE IN TALKING 2815 02:04:12,680 --> 02:04:14,800 ABOUT THE AGRICULTURAL EXTENSION 2816 02:04:14,800 --> 02:04:16,240 SERVICE IS HISTORICALLY 2817 02:04:16,240 --> 02:04:17,960 SOMETHING WHERE FARMERS WOULD 2818 02:04:17,960 --> 02:04:20,040 COME IN AND SAY CAN YOU ANALYZE 2819 02:04:20,040 --> 02:04:22,160 MY SOIL AND TALK ABOUT 2820 02:04:22,160 --> 02:04:23,280 FERTILIZER OR PESTICIDES AND ALL 2821 02:04:23,280 --> 02:04:25,880 THAT STUFF. 2822 02:04:25,880 --> 02:04:28,320 WHAT THE USDA OFFICIALS ARE 2823 02:04:28,320 --> 02:04:29,880 SAYING IS THE AGRO BUSINESSES DO 2824 02:04:29,880 --> 02:04:32,000 THAT AND SO THEIR FOCUS IS ON 2825 02:04:32,000 --> 02:04:36,680 THE HEALTH OF THEIR COMMUNITIES 2826 02:04:36,680 --> 02:04:37,520 BECAUSE THAT'S WHAT'S SUFFERING 2827 02:04:37,520 --> 02:04:41,080 AND ONE INDIVIDUAL SAID PEOPLE 2828 02:04:41,080 --> 02:04:43,080 TALK ABOUT FOOD DESERTS IN 2829 02:04:43,080 --> 02:04:44,880 CITIES IN RURAL COMMUNITIES WE 2830 02:04:44,880 --> 02:04:50,360 HAVE FOOD SLUWAMPS AND A DIFFERT 2831 02:04:50,360 --> 02:04:50,640 ISSUE. 2832 02:04:50,640 --> 02:04:52,360 THEY ARE FOCUSSED AND HAVE THE 2833 02:04:52,360 --> 02:04:56,000 CONNECTIONS AND THE ENGAGEMENT 2834 02:04:56,000 --> 02:04:58,960 AND TRUST OF THE COMMUNITY. 2835 02:04:58,960 --> 02:05:00,800 SO IT'S SOMETHING WE WERE 2836 02:05:00,800 --> 02:05:03,520 STARTING TO WORK ON PRE-COVID 2837 02:05:03,520 --> 02:05:05,800 AND COVID PUT A LOCK ON A LOT OF 2838 02:05:05,800 --> 02:05:07,080 ACTIVITIES BUT IT'S SOMETHING WE 2839 02:05:07,080 --> 02:05:10,960 NEED TO GET BACK TO BECAUSE IT'S 2840 02:05:10,960 --> 02:05:13,280 A VALUABLE ADDITION TO THE CTSA 2841 02:05:13,280 --> 02:05:15,040 TO HELP THEM AMPLIFY WHAT TO DO 2842 02:05:15,040 --> 02:05:17,600 IN THEIR REGION. 2843 02:05:17,600 --> 02:05:21,680 >>THANK YOU FOR THAT COMMENT, 2844 02:05:21,680 --> 02:05:22,120 PAULA. 2845 02:05:22,120 --> 02:05:23,520 I'M RECOGNIZING I THINK WE'RE A 2846 02:05:23,520 --> 02:05:25,560 LITTLE BIT OVER TIME, ANNA, HOW 2847 02:05:25,560 --> 02:05:26,240 ARE WE DOING? 2848 02:05:26,240 --> 02:05:29,160 ARE WE READY FOR A BREAK? 2849 02:05:29,160 --> 02:05:30,640 >>YES, ACTUALLY. 2850 02:05:30,640 --> 02:05:32,040 WE'RE A FEW MINUTES PAST SO 2851 02:05:32,040 --> 02:05:33,560 WE'VE GOT TIME ON THE BACK END 2852 02:05:33,560 --> 02:05:35,680 SO YES, TIME FOR A BREAK. 2853 02:05:35,680 --> 02:05:38,200 >>PERHAPS WE CAN PICK UP SOME 2854 02:05:38,200 --> 02:05:39,480 MORE OF THIS DISCUSSION MORE AT 2855 02:05:39,480 --> 02:05:41,880 THE END OF THE DAY IF THERE'S 2856 02:05:41,880 --> 02:05:45,200 TIME. 2857 02:05:45,200 --> 02:05:48,600 AND IF NOT, JUST FAIR WARNING 2858 02:05:48,600 --> 02:05:50,040 YOU'RE PROBABLY NOT GOING TO BE 2859 02:05:50,040 --> 02:05:51,880 OFF THE HOOK JUST YET. 2860 02:05:51,880 --> 02:05:54,600 I'LL PROBABLY REACH OUT MORE AND 2861 02:05:54,600 --> 02:05:56,400 THANK YOU IN ADVANCE BUT I ALSO 2862 02:05:56,400 --> 02:05:58,280 THANK YOU NOW FOR ALL THE INPUT 2863 02:05:58,280 --> 02:06:01,480 YOU HAVE GIVEN US FOR THESE 2864 02:06:01,480 --> 02:06:03,120 ADDITIONAL SUGGESTIONS AS WE 2865 02:06:03,120 --> 02:06:05,320 START TO FINAL I'D AND ROUND 2866 02:06:05,320 --> 02:06:07,040 THIS OUT WE HAVE A LITTLE BIT 2867 02:06:07,040 --> 02:06:10,280 MORE WORK TO DO BUT I THINK IT'S 2868 02:06:10,280 --> 02:06:12,360 REALLY EXCITING AND WITH THAT I 2869 02:06:12,360 --> 02:06:16,080 THINK WE CAN BREAK NOW AND ANNA 2870 02:06:16,080 --> 02:06:21,760 WOULD SHOULD THEY BE BACK? 2871 02:06:21,760 --> 02:06:23,280 >>LET'S SAY 3:25. 2872 02:06:23,280 --> 02:06:25,200 >>SOUNDS GOOD. 2873 02:06:25,200 --> 02:06:32,120 SEE YOU SOON. 2874 02:06:32,120 --> 02:06:35,000 THE FIRST PRESENTATION IS FROM 2875 02:06:35,000 --> 02:06:37,680 THE DIVISION OF CLINIC 2876 02:06:37,680 --> 02:06:40,600 INNOVATION AND WILL 2877 02:06:40,600 --> 02:06:43,040 INTRODUCE THE TALK FROM THEIR 2878 02:06:43,040 --> 02:06:49,080 PERSPECTIVE AND I'LL LET YOU 2879 02:06:49,080 --> 02:06:53,040 INTRODUCE DR. MATHE. 2880 02:06:53,040 --> 02:06:59,360 >>DIRECTOR FOR INFORMATICS AT 2881 02:06:59,360 --> 02:07:09,920 THE NCATS SHE JOINED FROM OHIO 2882 02:07:12,040 --> 02:07:18,560 STATE UNIVERSITY SHE STARTED 2883 02:07:18,560 --> 02:07:20,960 AFTER COVID INSTRUCTIONS WERE 2884 02:07:20,960 --> 02:07:21,400 IMPROVED. 2885 02:07:21,400 --> 02:07:25,440 DESPITE THIS CHALLENGE SHE WAS 2886 02:07:25,440 --> 02:07:27,000 ABLE TO ORGANIZE HER TEAM TO 2887 02:07:27,000 --> 02:07:32,280 PRODUCE TRANSFORMATIVE WORK NOT 2888 02:07:32,280 --> 02:07:38,080 JUST IN RESPONSE TO THE PANDEMIC 2889 02:07:38,080 --> 02:07:45,640 THE SARS COV2 INFECTION WORK AND 2890 02:07:45,640 --> 02:07:46,320 THE FLOOR IS YOURS. 2891 02:07:46,320 --> 02:07:47,880 >>I'LL SHOW YOU SOME OF THE 2892 02:07:47,880 --> 02:07:50,680 WORK WE'VE BEEN DOING IN THE 2893 02:07:50,680 --> 02:07:51,320 INFORMATICS AND WE REFER TO IT 2894 02:07:51,320 --> 02:07:58,120 AS ISS. 2895 02:07:58,120 --> 02:08:00,480 FIRST I'M GIVE YOU BACKGROUND 2896 02:08:00,480 --> 02:08:02,960 INFORMATICS AND THE DIVISION OF 2897 02:08:02,960 --> 02:08:05,680 PRECLINICAL INNOVATION 2898 02:08:05,680 --> 02:08:09,600 INFORMATICS CORPS AND HOW THIS 2899 02:08:09,600 --> 02:08:10,800 RELATE TO NCATS. 2900 02:08:10,800 --> 02:08:15,000 OUR MISSION AND GOALS AND 2901 02:08:15,000 --> 02:08:18,600 CULTURE AND THEN GO INTO THREE 2902 02:08:18,600 --> 02:08:19,960 DIFFERENT AREAS WE'VE DONE. 2903 02:08:19,960 --> 02:08:22,600 THE FIRST RELATED TO COVID-19 2904 02:08:22,600 --> 02:08:24,720 AND AS AN EXAMPLE HOW WE'VE BEEN 2905 02:08:24,720 --> 02:08:27,840 ABLE TO PUSH THE BOUNDARIES OF 2906 02:08:27,840 --> 02:08:29,120 INFORMATICS AND I'LL ALSO TALK 2907 02:08:29,120 --> 02:08:31,360 ABOUT WAYS IN WHICH WE DERIVE 2908 02:08:31,360 --> 02:08:34,400 ACTIONABLE INSIGHTS BY 2909 02:08:34,400 --> 02:08:35,160 INTEGRATING DIFFERENT TYPES OF 2910 02:08:35,160 --> 02:08:36,160 COMPLEX DATA. 2911 02:08:36,160 --> 02:08:39,000 AND FINALLY I'LL TOUCH ON NEW 2912 02:08:39,000 --> 02:08:42,200 TECHNOLOGIES THAT WE'RE BRINGING 2913 02:08:42,200 --> 02:08:48,480 TO NCATS AROUND METABOLOMICS AND 2914 02:08:48,480 --> 02:08:48,800 MULTIOMICS. 2915 02:08:48,800 --> 02:08:50,840 WHEN WE THINK OF DATA I THINK WE 2916 02:08:50,840 --> 02:08:56,240 ALL KNOW THERE'S A LOT OF DATA 2917 02:08:56,240 --> 02:08:57,680 COMING AT US. 2918 02:08:57,680 --> 02:09:00,320 THE TOP LEFT STICK TURE IS AN 2919 02:09:00,320 --> 02:09:03,320 OLD CART FROM THE ECONOMIST IN 2920 02:09:03,320 --> 02:09:03,920 2010. 2921 02:09:03,920 --> 02:09:07,880 IT SHOWS THE DATA DELUGE BEING 2922 02:09:07,880 --> 02:09:10,520 FUNDED BY AN UMBRELLA AND 2923 02:09:10,520 --> 02:09:11,760 INTERPRETED FOR THE FLOWER WHICH 2924 02:09:11,760 --> 02:09:14,080 CAN BE THOUGHT OF THE ACTIONABLE 2925 02:09:14,080 --> 02:09:17,800 INPUT. 2926 02:09:17,800 --> 02:09:19,400 I ALWAYS REFER TO THIS AND THINK 2927 02:09:19,400 --> 02:09:21,000 ABOUT IT BECAUSE THERE'S STILL A 2928 02:09:21,000 --> 02:09:23,520 LOT OF DATA COMING AT US AND IF 2929 02:09:23,520 --> 02:09:34,120 YOU LOOK AT THE BOTTOM LEFT 2930 02:09:34,120 --> 02:09:37,120 BEFORE THE '60 WE HAD 2931 02:09:37,120 --> 02:09:38,880 QUALITATIVE AND THEN 2932 02:09:38,880 --> 02:09:40,400 QUANTITATIVE AND WE SAW A 2933 02:09:40,400 --> 02:09:41,200 TECHNOLOGY REVOLUTION WHERE WE 2934 02:09:41,200 --> 02:09:45,000 WERE ABLE TO MEASURE MORE THINGS 2935 02:09:45,000 --> 02:09:45,400 IN SPECIFIC WAYS. 2936 02:09:45,400 --> 02:09:49,880 BETWEEN THE '80s AND 2010 WE SAW 2937 02:09:49,880 --> 02:09:51,560 AN EXPANSION OF THESE 2938 02:09:51,560 --> 02:09:54,080 TECHNOLOGIES BEING APPLIED IN 2939 02:09:54,080 --> 02:09:56,480 DIFFERENT APPLICATIONS IN 2940 02:09:56,480 --> 02:09:58,400 DIFFERENT AREAS AND BEYOND 2010 2941 02:09:58,400 --> 02:10:00,640 THERE'S A LOT OF AUTOMATION AND 2942 02:10:00,640 --> 02:10:02,800 WE ALL KNOW NCATS PLAYS A KEY 2943 02:10:02,800 --> 02:10:05,400 ROLE HERE IN BEING ABLE TO 2944 02:10:05,400 --> 02:10:07,320 AUTOMATE AND GENERATE HIGH 2945 02:10:07,320 --> 02:10:09,000 QUALITY ROBUST DATA AT A LARGE 2946 02:10:09,000 --> 02:10:09,880 ZAL. 2947 02:10:09,880 --> 02:10:13,800 -- SCALE. 2948 02:10:13,800 --> 02:10:14,760 THIS IS GREAT. 2949 02:10:14,760 --> 02:10:16,160 NOW WE HAVE A LOT OF DATA BUT 2950 02:10:16,160 --> 02:10:18,080 THE DATA TYPES AND THE 2951 02:10:18,080 --> 02:10:23,800 COMPLEXITY OF THE DATA ARE 2952 02:10:23,800 --> 02:10:26,080 INCREA 2953 02:10:26,080 --> 02:10:27,840 INCREASING CONDUCTING 2954 02:10:27,840 --> 02:10:29,960 LARGE-SCALE STUDIES ARE DATA 2955 02:10:29,960 --> 02:10:31,120 EXTENSIVE AND HARD TO EXTRACT 2956 02:10:31,120 --> 02:10:33,040 MEANING FROM ALL THE DATA AND 2957 02:10:33,040 --> 02:10:34,480 DERIVE THE ACTIONABLE INSIGHT. 2958 02:10:34,480 --> 02:10:42,080 TODAY I'M GOING TO TALK ABOUT 2959 02:10:42,080 --> 02:10:45,400 HOW AND DISSEMINATING DATA AND 2960 02:10:45,400 --> 02:10:47,280 ANALYZING DATA USING THE TOOLS 2961 02:10:47,280 --> 02:10:48,640 WE GENERATE IN HOUSE BUT ALSO 2962 02:10:48,640 --> 02:10:51,840 TOOLS THAT WE GENERATE IN 2963 02:10:51,840 --> 02:10:54,280 COLLABORATION WITH OTHER 2964 02:10:54,280 --> 02:10:58,560 EXPERTS. 2965 02:10:58,560 --> 02:11:01,480 AS A REMINDER THE MISSION IS TO 2966 02:11:01,480 --> 02:11:03,840 TRANSFORM DISCOVERY APPROACH AND 2967 02:11:03,840 --> 02:11:06,240 TOOLS, ADVANCE TEAM SCIENCE AND 2968 02:11:06,240 --> 02:11:08,240 CATALYZE THE BIO MEDICAL 2969 02:11:08,240 --> 02:11:10,080 COMMUNITY TO DELIVER MOST 2970 02:11:10,080 --> 02:11:11,800 EFFECTIVE THERAPIES TO TREAT 2971 02:11:11,800 --> 02:11:13,760 HUMAN DISEASES. 2972 02:11:13,760 --> 02:11:15,880 WITHIN THIS OUR MISSION IS TO 2973 02:11:15,880 --> 02:11:18,080 DERIVE ACTIONABLE INSIGHT FROM 2974 02:11:18,080 --> 02:11:20,320 INTEGRATING TRANSLATIONAL 2975 02:11:20,320 --> 02:11:22,040 RESEARCH DATA AND TO ACCELERATE 2976 02:11:22,040 --> 02:11:25,600 TRANSLATION OF FINDINGS INTO THE 2977 02:11:25,600 --> 02:11:26,080 CLINIC. 2978 02:11:26,080 --> 02:11:27,600 SO CONCEPTUALLY WHAT THIS MEANS 2979 02:11:27,600 --> 02:11:29,160 IF YOU LOOK AT THE BOTTOM HERE 2980 02:11:29,160 --> 02:11:31,920 WE LOOK AT VARIOUS TYPES OF DATA 2981 02:11:31,920 --> 02:11:34,680 FROM BASIC PRE CLINICAL TO 2982 02:11:34,680 --> 02:11:36,840 CLINICAL DATA AND THE DATA COME 2983 02:11:36,840 --> 02:11:38,360 IN MANY DIFFERENT TYPES OF 2984 02:11:38,360 --> 02:11:38,840 FLAVORS. 2985 02:11:38,840 --> 02:11:40,920 SOME COULD BE EXPERIMENTAL 2986 02:11:40,920 --> 02:11:43,080 MEASUREMENTS AND IT COULD COME 2987 02:11:43,080 --> 02:11:47,600 FROM LITERATURE, SOCIAL MEDIA 2988 02:11:47,600 --> 02:11:49,720 AND ETCETERA. 2989 02:11:49,720 --> 02:11:55,160 AND WE INTEGRATE ALL THE 2990 02:11:55,160 --> 02:12:05,240 INFORMATION AND WE GET THIS AND 2991 02:12:05,240 --> 02:12:06,440 THEN WE ANSWER SPECIFIC 2992 02:12:06,440 --> 02:12:09,200 QUESTIONS AND YOU CAN SEE AN 2993 02:12:09,200 --> 02:12:17,480 ORDER OF PATTERNS. 2994 02:12:17,480 --> 02:12:18,680 AND ACTIONABLE INSIGHT WHICH AT 2995 02:12:18,680 --> 02:12:21,200 THE END OF THE DAY WE WANT TO 2996 02:12:21,200 --> 02:12:31,320 REACH. 2997 02:12:32,880 --> 02:12:36,440 A LITTLE BIT ABOUT THE RESEARCH 2998 02:12:36,440 --> 02:12:36,640 AREAS. 2999 02:12:36,640 --> 02:12:38,040 INFORMATICS WAS ONE OF THE 3000 02:12:38,040 --> 02:12:43,160 BRANCHES OF THE EARLY 3001 02:12:43,160 --> 02:12:48,280 TRANSLATION BRARCHLG AND -- 3002 02:12:48,280 --> 02:12:52,920 BRANCH AND IT WAS INFORMATICS 3003 02:12:52,920 --> 02:12:54,080 HEAVY. 3004 02:12:54,080 --> 02:13:03,680 THEN IN 2021 TO NOW IT'S 3005 02:13:03,680 --> 02:13:08,000 EXPANDED TO DIFFERENT AREAS AND 3006 02:13:08,000 --> 02:13:11,560 SOME INCLUDE MOLECULAR PROFILING 3007 02:13:11,560 --> 02:13:16,040 AND MOLECULAR EPIDEMIOLOGY WORK. 3008 02:13:16,040 --> 02:13:18,840 THE NEW AREAS WE DELVE INTO COME 3009 02:13:18,840 --> 02:13:21,760 TO THE HISTORICAL SCALE AND THE 3010 02:13:21,760 --> 02:13:26,080 ONGOING EFFORTS IN THE FUTURE 3011 02:13:26,080 --> 02:13:27,000 EFFORTS THAT WE'RE PLANNING. 3012 02:13:27,000 --> 02:13:30,080 IF YOU LOOK AT THE LEFT YOU CAN 3013 02:13:30,080 --> 02:13:32,120 SEE AREAS IN TEAL IDENTIFYING 3014 02:13:32,120 --> 02:13:34,720 MECHANISMS AND TARGETS IN 3015 02:13:34,720 --> 02:13:38,680 MODELS, TESTING CHEMICALS AND 3016 02:13:38,680 --> 02:13:40,440 ASSAYS AND PUBLICLY 3017 02:13:40,440 --> 02:13:41,600 DISSEMINATING THE RESULTS, ARE 3018 02:13:41,600 --> 02:13:43,920 ALWAYS PART OF IFX. 3019 02:13:43,920 --> 02:13:46,320 THEY STILL ARE TODAY. 3020 02:13:46,320 --> 02:13:49,520 THE NEW AREAS THAT WE'RE DELVING 3021 02:13:49,520 --> 02:13:53,560 IN IS DEVELOPING NEW ASSAY TYPES 3022 02:13:53,560 --> 02:13:56,000 I'LL TALK BAND ASSESSING 3023 02:13:56,000 --> 02:13:57,000 MECHANISMS AN TARGETS IN 3024 02:13:57,000 --> 02:13:59,280 POPULATION IN ADDITION TO MODELS 3025 02:13:59,280 --> 02:14:02,640 AND IDENTIFYING PREDICTIONS. 3026 02:14:02,640 --> 02:14:05,480 OF COURSE ALL THESE EFFORTS FALL 3027 02:14:05,480 --> 02:14:07,400 UNDER THE UMBRELLA OF USING 3028 02:14:07,400 --> 02:14:10,080 INFORMATION SO THEY CAN INFORM 3029 02:14:10,080 --> 02:14:14,080 CLINICAL TRIALS AND FDA 3030 02:14:14,080 --> 02:14:24,240 APPROVED. 3031 02:14:26,800 --> 02:14:29,640 THERE'S TEAM SCIENCE IN OUR 3032 02:14:29,640 --> 02:14:29,840 WORK. 3033 02:14:29,840 --> 02:14:32,320 WE HAVE EXPERTS IN INFORMATICS 3034 02:14:32,320 --> 02:14:34,080 AND DIFFERENT OMICS, MACHINE 3035 02:14:34,080 --> 02:14:35,920 LEARNING, SOFTWARE DEVELOPMENT 3036 02:14:35,920 --> 02:14:37,760 AND ALSO PROJECT MANAGEMENT 3037 02:14:37,760 --> 02:14:40,040 WHICH I PERSONALLY VALUE VERY 3038 02:14:40,040 --> 02:14:40,240 MUCH. 3039 02:14:40,240 --> 02:14:42,840 IT WAS KNEW TO ME WHEN I CAME 3040 02:14:42,840 --> 02:14:49,400 HERE AND HAD THE LUXURY IN 3041 02:14:49,400 --> 02:14:50,040 ACADEMIA. 3042 02:14:50,040 --> 02:14:53,200 OF COURSE WITH COLLABORATE WITH 3043 02:14:53,200 --> 02:14:56,680 OTHER NCATS AND THERE'S IN 3044 02:14:56,680 --> 02:14:57,720 BIOLOGY, CHEMISTRY AND THERE'S 3045 02:14:57,720 --> 02:15:01,080 MANY EXPERTS BUT THE POINT IS 3046 02:15:01,080 --> 02:15:03,960 THAT EVERYBODY TALKED TO EACH 3047 02:15:03,960 --> 02:15:06,360 OTHER PRETTY EFFICIENTLY BECAUSE 3048 02:15:06,360 --> 02:15:07,920 WE KNOW ENOUGH ABOUT THE OTHER 3049 02:15:07,920 --> 02:15:10,720 FIELD TO FIND WAYS OF 3050 02:15:10,720 --> 02:15:13,200 COMMUNICATING AND I THINK THAT'S 3051 02:15:13,200 --> 02:15:14,080 IMPORTANT. 3052 02:15:14,080 --> 02:15:15,560 THE ABILITY TO BE MULTILINGUAL. 3053 02:15:15,560 --> 02:15:17,560 WE MAY NOT BE EXPERTS IN SORN 3054 02:15:17,560 --> 02:15:19,480 AREAS BUT KNOW ENOUGH TO BE ABLE 3055 02:15:19,480 --> 02:15:22,600 TO CONVERT WITH PEOPLE IN THOSE 3056 02:15:22,600 --> 02:15:22,800 FIELDS. 3057 02:15:22,800 --> 02:15:27,040 AT THE END OUR GOAL IS TO DEEPLY 3058 02:15:27,040 --> 02:15:29,240 UNDERSTAND THE DETE BECAUSE WHEN 3059 02:15:29,240 --> 02:15:30,600 WE UNDERSTAND THE DATA HOW IT'S 3060 02:15:30,600 --> 02:15:32,040 BEING GENERATE AND WHY IT'S 3061 02:15:32,040 --> 02:15:35,440 BEING GENERATED AND THEN WE CAN 3062 02:15:35,440 --> 02:15:42,320 INFER THE ACTIONABLE INSIGHTS. 3063 02:15:42,320 --> 02:15:45,080 SO NOW I'M GOING DELVE INTO 3064 02:15:45,080 --> 02:15:46,080 THREE DIFFERENT AREAS OF WORK 3065 02:15:46,080 --> 02:15:51,160 WE'VE BEEN DOING AND STARTING 3066 02:15:51,160 --> 02:15:53,560 WITH COVID-19. 3067 02:15:53,560 --> 02:15:56,440 AND I'M SURE MANY ARE AWARE OF 3068 02:15:56,440 --> 02:15:58,200 THE COHORT COLLABORATIVE AND 3069 02:15:58,200 --> 02:16:00,160 THIS STARTED EARLY ON IN THE 3070 02:16:00,160 --> 02:16:02,440 PANDEMIC AND I'M SURE ALL OF YOU 3071 02:16:02,440 --> 02:16:06,080 REMEMBER THERE WERE REAL TIME 3072 02:16:06,080 --> 02:16:08,640 TRACKERS THAT WERE COMING OUT. 3073 02:16:08,640 --> 02:16:12,680 THIS I THINK OF AS A REAL-TIME 3074 02:16:12,680 --> 02:16:16,000 TRACKING FOR EHR DATA IN 3075 02:16:16,000 --> 02:16:18,080 COVID-19 AND IT'S ONE OF THEEST 3076 02:16:18,080 --> 02:16:19,840 COLLECTIONS MUCH HARMONIZED 3077 02:16:19,840 --> 02:16:20,920 CLINICAL HEALTH DATA IN THE 3078 02:16:20,920 --> 02:16:21,760 UNITED STATES. 3079 02:16:21,760 --> 02:16:23,160 IT'S HUGE. 3080 02:16:23,160 --> 02:16:26,680 IT HAS 76 SITES OVER 18 MILLION 3081 02:16:26,680 --> 02:16:27,840 PERSONS AND OVER 7 MILLION COVID 3082 02:16:27,840 --> 02:16:28,680 POSITIVE CASES. 3083 02:16:28,680 --> 02:16:33,040 ALL THIS DATA IS HOSTED IN A 3084 02:16:33,040 --> 02:16:35,560 SECURE DATA ENCLAVE AT NCATS. 3085 02:16:35,560 --> 02:16:37,160 I CAN'T STRESS HOW IMPORTANT 3086 02:16:37,160 --> 02:16:41,280 THIS IS BECAUSE TO PUT TOGETHER 3087 02:16:41,280 --> 02:16:43,400 DATA EVEN FROM TWO DIFFERENT 3088 02:16:43,400 --> 02:16:44,960 INSTITUTIONS ON YOUR OWN WITHOUT 3089 02:16:44,960 --> 02:16:46,520 THIS HUGE UMBRELLA THAT CAN TAKE 3090 02:16:46,520 --> 02:16:49,160 YEARS SOMETIMES TO GET THE 3091 02:16:49,160 --> 02:16:49,880 APPROPRIATE AGREEMENTS TO GET 3092 02:16:49,880 --> 02:16:51,480 THE APPROPRIATE DATA AND 3093 02:16:51,480 --> 02:16:54,040 UNDERSTAND HOW THE DATA IS 3094 02:16:54,040 --> 02:16:56,160 GENERATED TO HARMONIZE. 3095 02:16:56,160 --> 02:16:57,400 WE'RE USING THIS RESOURCE. 3096 02:16:57,400 --> 02:17:03,200 I'M GOING GIVE YOU AN EXAMPLE OF 3097 02:17:03,200 --> 02:17:05,560 A STUDY WHICH WAS RECENTLY 3098 02:17:05,560 --> 02:17:06,760 ACCEPTED AND WILL BE PUBLISHED 3099 02:17:06,760 --> 02:17:07,040 VERY SOON. 3100 02:17:07,040 --> 02:17:11,200 THIS STUDY IS LOOKING AT 3101 02:17:11,200 --> 02:17:14,680 PRE-EXISTING AUTOIMMUNITY AS A 3102 02:17:14,680 --> 02:17:15,800 RISK FACTOR FOR COVID-19. 3103 02:17:15,800 --> 02:17:16,760 WE WERE INTERESTED IN THIS 3104 02:17:16,760 --> 02:17:18,400 BECAUSE WE WERE LOOKING AT THE 3105 02:17:18,400 --> 02:17:21,320 CDC LIST OF RISK FACTORS. 3106 02:17:21,320 --> 02:17:26,080 TYPE 1 DIABETES WAS LISTED BUT 3107 02:17:26,080 --> 02:17:26,720 NO OTHER AUTOIMMUNE DISEASES 3108 02:17:26,720 --> 02:17:27,480 WERE LISTED. 3109 02:17:27,480 --> 02:17:29,560 THERE'S A PRECEDENCE FOR 3110 02:17:29,560 --> 02:17:31,480 THINKING AUTOIMMUNITY OR 3111 02:17:31,480 --> 02:17:33,160 TREATMENT BY IMMUNOSUPPRESSIVE 3112 02:17:33,160 --> 02:17:36,280 DRUGS COULD HAVE A STRONG IMPACT 3113 02:17:36,280 --> 02:17:39,000 ON THE RESPONSE TO COVID-19. 3114 02:17:39,000 --> 02:17:43,480 AND SO OUR GOAL WAS TO DIRECTLY 3115 02:17:43,480 --> 02:17:44,640 EVALUATE IN A LARGE POPULATION 3116 02:17:44,640 --> 02:17:48,680 RIGHT AT NCC THE IMPACT OF 3117 02:17:48,680 --> 02:17:51,040 AUTOIMMUNITY AND THE EXPOSURE TO 3118 02:17:51,040 --> 02:17:53,840 IMMUNOEXPRESSIVE DRUGS ON 3119 02:17:53,840 --> 02:17:54,120 COVID-19. 3120 02:17:54,120 --> 02:17:56,040 IT'S IMPORTANT BECAUSE THE IDEA 3121 02:17:56,040 --> 02:17:58,080 IS TO HELP INFORM HEALTH CARE 3122 02:17:58,080 --> 02:17:59,560 GUIDELINES AND RAISE AWARENESS 3123 02:17:59,560 --> 02:18:01,360 FOR PATIENTS AT RISK. 3124 02:18:01,360 --> 02:18:04,360 SO WE WERE ABLE TO GENERATE A 3125 02:18:04,360 --> 02:18:08,640 COHORT OF OVER 2.4 MILLION 3126 02:18:08,640 --> 02:18:08,960 PATIENTS. 3127 02:18:08,960 --> 02:18:16,720 SOME ABOUT 190,000 HAVE 3128 02:18:16,720 --> 02:18:19,600 PRE-EXISTED AUTOIMMUNE DISEASE 3129 02:18:19,600 --> 02:18:24,480 AND ABOUT 50,000 HAD BOTH AND WE 3130 02:18:24,480 --> 02:18:30,120 FOUND THAT ADULTS WITH 3131 02:18:30,120 --> 02:18:32,120 PRE-EXISTING AUTOIMMUNE DISEASE 3132 02:18:32,120 --> 02:18:33,120 IMMUNO SUPPRESSIVE DRUG OR BOTH 3133 02:18:33,120 --> 02:18:34,880 ARE MORE LIKELY TO HAVE MORE 3134 02:18:34,880 --> 02:18:36,840 SEVERE DISEASE OUTCOMES. 3135 02:18:36,840 --> 02:18:39,560 THE RESULTS ARE CONSISTENT EVEN 3136 02:18:39,560 --> 02:18:42,680 WHEN WE ADJUST FOR VACCINATION 3137 02:18:42,680 --> 02:18:49,800 STATUS OR ANTI-VIRAL GENES. 3138 02:18:49,800 --> 02:18:51,120 ANOTHER LARGE SCALE STUDY 3139 02:18:51,120 --> 02:18:54,080 POSSIBLE DURING COVID-19 WHICH I 3140 02:18:54,080 --> 02:18:57,040 FEEL WOULD HAVE BEEN A LITTLE 3141 02:18:57,040 --> 02:18:59,760 BIT HARDER IN PREVIOUS PANDEMIC 3142 02:18:59,760 --> 02:19:02,320 TIMES IS LOOKING AT A LARGE 3143 02:19:02,320 --> 02:19:05,120 COHORT OF PATIENTS AND LOOKING 3144 02:19:05,120 --> 02:19:07,560 AT THEIR METABOLISM AND SEE 3145 02:19:07,560 --> 02:19:08,720 WHETHER THERE'S ANY 3146 02:19:08,720 --> 02:19:10,560 CHARACTERISTICS OF THE 3147 02:19:10,560 --> 02:19:12,200 METABOLISM THAT PRE-EXPOSES 3148 02:19:12,200 --> 02:19:14,480 PATIENTS TO SEVERE COVID. 3149 02:19:14,480 --> 02:19:18,080 AND THIS SAY COLLABORATION WITH 3150 02:19:18,080 --> 02:19:23,640 HARVARD MEDICAL SCHOOL AND WE 3151 02:19:23,640 --> 02:19:25,240 COLLECTED IN-PATIENT PRIOR TO 3152 02:19:25,240 --> 02:19:28,320 THEM HAVING COVID AND WE WERE 3153 02:19:28,320 --> 02:19:29,840 ABLE TO ACCESS THE SAMPLES 3154 02:19:29,840 --> 02:19:31,680 THROUGH A BIO BANK AND ANALYZE 3155 02:19:31,680 --> 02:19:33,480 THEM FOR WHAT WE CALL THE 3156 02:19:33,480 --> 02:19:33,800 METABOLOME. 3157 02:19:33,800 --> 02:19:36,560 THIS IS LOOKING AT ALL THE SMALL 3158 02:19:36,560 --> 02:19:39,680 MOLECULES RELATED TO METABOLISM. 3159 02:19:39,680 --> 02:19:44,400 AND WE ALSO HAD PLASMA ON 3160 02:19:44,400 --> 02:19:45,360 PATIENTS DURING ACTIVE DISEASE 3161 02:19:45,360 --> 02:19:46,080 AND AFTER. 3162 02:19:46,080 --> 02:19:49,440 WE WERE ABLE TO TRACK WHETHER 3163 02:19:49,440 --> 02:19:52,240 THE PREDISPOSITION FACTORS GOT 3164 02:19:52,240 --> 02:19:54,080 WORSE DURING DISEASE AND WHAT 3165 02:19:54,080 --> 02:19:59,280 HAPPENED AFTER. 3166 02:19:59,280 --> 02:20:00,560 THIS STUDY IS PARTICULARLY 3167 02:20:00,560 --> 02:20:02,080 IMPORTANT BECAUSE OTHER STUDIES 3168 02:20:02,080 --> 02:20:04,040 WERE TRYING TO GET AT THIS BUT 3169 02:20:04,040 --> 02:20:06,080 WERE EITHER LIMITED IN SIZE, 3170 02:20:06,080 --> 02:20:08,240 LOOKED AT A SINGLE TIME POINT 3171 02:20:08,240 --> 02:20:09,680 AND NONE OF THEM HAD A TIME 3172 02:20:09,680 --> 02:20:11,520 POINT OF COLLECTION THAT WAS 3173 02:20:11,520 --> 02:20:11,920 PRIOR TO COVID. 3174 02:20:11,920 --> 02:20:14,080 HERE WE'RE LOOKING AT THE 3175 02:20:14,080 --> 02:20:17,120 PREDISPOSITION. 3176 02:20:17,120 --> 02:20:20,600 WHAT WE FOUND IS AMINO ACID 3177 02:20:20,600 --> 02:20:22,080 NUCLEOTIDES AND SINGLE LIPIDS 3178 02:20:22,080 --> 02:20:24,520 ARE ASSOCIATED WITH SEVERE 3179 02:20:24,520 --> 02:20:25,600 COVID-19 OUTCOMES. 3180 02:20:25,600 --> 02:20:30,240 AND THIS STUDY IS LAYING 3181 02:20:30,240 --> 02:20:31,160 FOUNDATIONAL WORK FOR 3182 02:20:31,160 --> 02:20:33,040 IDENTIFYING BIOMARKERS AND 3183 02:20:33,040 --> 02:20:35,480 LOOKING FOR MOLECULAR FUNCTIONS 3184 02:20:35,480 --> 02:20:42,160 THAT PREDISPOSE. 3185 02:20:42,160 --> 02:20:43,680 THE THIRD EXAMPLE I WANT TO GIVE 3186 02:20:43,680 --> 02:20:45,400 IS GOING BACK TO REAL-WORLD 3187 02:20:45,400 --> 02:20:46,880 DATA. 3188 02:20:46,880 --> 02:20:51,040 THIS IS AN EFFORT CALLED CURE 3189 02:20:51,040 --> 02:20:51,200 I.D. 3190 02:20:51,200 --> 02:20:53,920 AND IT HAS INFORMATION ON NOVEL 3191 02:20:53,920 --> 02:20:57,240 USES OF EXISTING DRUGS FROM 3192 02:20:57,240 --> 02:20:59,560 CLINICIANS AND COMING VERY ZOON 3193 02:20:59,560 --> 02:21:02,600 FROM PATIENTS AND THE IDEA IS TO 3194 02:21:02,600 --> 02:21:06,080 USE THE DATA TO IDENTIFY DRUG 3195 02:21:06,080 --> 02:21:07,880 REPURPOSING CANDIDATES TO 3196 02:21:07,880 --> 02:21:09,960 PROVIDE EVIDENCE FOR EXPANDING 3197 02:21:09,960 --> 02:21:12,280 DRUG LABELS AND FOR INFORMING 3198 02:21:12,280 --> 02:21:14,520 THE DESIGN OF CLINICAL TRIALS. 3199 02:21:14,520 --> 02:21:17,880 AND YOU CAN SEE ON THE BOTTOM 3200 02:21:17,880 --> 02:21:20,080 LEFT A PICTURE OF THE WEB 3201 02:21:20,080 --> 02:21:21,800 APPLICATION WHICH IS ALSO A 3202 02:21:21,800 --> 02:21:24,760 MOBILE APP WHERE PHYSICIANS AND 3203 02:21:24,760 --> 02:21:26,080 PATIENTS CAN ENTER INFORMATION 3204 02:21:26,080 --> 02:21:27,800 SO THIS SAY LARGE COLLABORATION 3205 02:21:27,800 --> 02:21:33,840 WE HAD WITH THE FDA AND THE 3206 02:21:33,840 --> 02:21:36,440 CRITICAL PATH INSTITUTE AND THIS 3207 02:21:36,440 --> 02:21:42,680 WAS SUPPORTED NEW WORK WITH THE 3208 02:21:42,680 --> 02:21:44,720 HHS WHICH ENABLED US TO LOOK AT 3209 02:21:44,720 --> 02:21:47,240 DIFFERENT WAYS OF INCORPORATING 3210 02:21:47,240 --> 02:21:48,760 DATA INTO CURE I.D. AND THAT WAY 3211 02:21:48,760 --> 02:21:51,440 IS THROUGH E.H.R.s. 3212 02:21:51,440 --> 02:21:54,800 SO THIS IS SIMILAR IN THE SENSE 3213 02:21:54,800 --> 02:21:56,800 IT'S E.H.R. DATA BUT THERE'S KEY 3214 02:21:56,800 --> 02:21:57,480 DISTINCTIONS. 3215 02:21:57,480 --> 02:22:01,720 ONE KEY DISTINCTION IS IT THAT 3216 02:22:01,720 --> 02:22:03,040 NATIONAL SITES CAN CONTRIBUTE 3217 02:22:03,040 --> 02:22:07,080 DATA AND ANOTHER DISTINCTION IS 3218 02:22:07,080 --> 02:22:08,840 THAT THE UNDERLYING DATA MODELS 3219 02:22:08,840 --> 02:22:11,680 USED DON'T HAVE TO BE ONE OF 3220 02:22:11,680 --> 02:22:14,480 THOSE LARGE COMMON ONES. 3221 02:22:14,480 --> 02:22:15,680 SO THOSE SMALL INSTITUTIONS THAT 3222 02:22:15,680 --> 02:22:16,880 DON'T HAVE THE LARGE 3223 02:22:16,880 --> 02:22:19,440 INFRASTRUCTURE TO HAVE THE 3224 02:22:19,440 --> 02:22:22,400 ELECTRONIC HEALTH RECORD WELL 3225 02:22:22,400 --> 02:22:24,160 ORGANIZED AND INTEGRATABLE WITH 3226 02:22:24,160 --> 02:22:25,120 OTHER INSTITUTIONS, THEY'RE ABLE 3227 02:22:25,120 --> 02:22:28,680 TO PARTICIPATE AND THEY ARE. 3228 02:22:28,680 --> 02:22:31,800 THE MAJORITY OF THE INSTITUTION 3229 02:22:31,800 --> 02:22:33,800 THE SMALLER -- SOME LESS 3230 02:22:33,800 --> 02:22:34,320 RESOURCED INSTITUTIONS. 3231 02:22:34,320 --> 02:22:39,600 ALL THE DATA HERE IS PUBLIC. 3232 02:22:39,600 --> 02:22:41,240 AND SO THERE'S THE RELEASE OF 3233 02:22:41,240 --> 02:22:43,800 THIS THAT'S GOING TO BE COMING 3234 02:22:43,800 --> 02:22:47,480 OUT SOON. 3235 02:22:47,480 --> 02:22:51,440 SOMETHING TO LOOK OUT FOR AND 3236 02:22:51,440 --> 02:22:57,600 WHILE THIS WAS BILL -- BUILT 3237 02:22:57,600 --> 02:22:58,280 FOR COVID-19 THE INFRASTRUCTURE 3238 02:22:58,280 --> 02:23:01,960 SIN PLACE TO BE ABLE TO OPEN -- 3239 02:23:01,960 --> 02:23:06,080 IS IN PLACE TO OPEN IT UP TO 3240 02:23:06,080 --> 02:23:08,960 OTHER DISEASES AND OF COURSE 3241 02:23:08,960 --> 02:23:10,640 THIS IS PLANNED. 3242 02:23:10,640 --> 02:23:12,320 I'LL SWITCH GEARS A LITTLE BIT 3243 02:23:12,320 --> 02:23:19,240 FROM COVID-19 AND HOW WE DERIVED 3244 02:23:19,240 --> 02:23:21,040 ACTIONABLE INSIGHT FROM THE 3245 02:23:21,040 --> 02:23:21,400 DATA. 3246 02:23:21,400 --> 02:23:23,720 MOST ARE FAMILIAR WITH DATA 3247 02:23:23,720 --> 02:23:26,080 REPOSITORY AND THEY PROVIDE 3248 02:23:26,080 --> 02:23:28,760 ACCESS TO DATA AND FOR EXAMPLE 3249 02:23:28,760 --> 02:23:30,560 HOW IS IT COLLECTED AND MAYBE 3250 02:23:30,560 --> 02:23:33,480 SOME ASPECTS OF STUDY DESIGN. 3251 02:23:33,480 --> 02:23:36,760 THEY HAVE KEY LIMITATIONS THAT 3252 02:23:36,760 --> 02:23:38,080 I'D LIKE TO HIGHLIGHT. 3253 02:23:38,080 --> 02:23:41,360 FIRST IF YOU'RE TRYING TO DO A 3254 02:23:41,360 --> 02:23:44,600 STUDY WHERE YOU'RE TRYING TO 3255 02:23:44,600 --> 02:23:45,960 REDUCE EXISTING DATA IT TAKES 3256 02:23:45,960 --> 02:23:47,560 QUITE A BIT OF TIME AND 3257 02:23:47,560 --> 02:23:47,840 RESOURCES. 3258 02:23:47,840 --> 02:23:50,320 THOUGH YOU MAY GET ACCESS TO THE 3259 02:23:50,320 --> 02:23:51,840 DATA THE FLAVOR OF THE DATA AND 3260 02:23:51,840 --> 02:23:54,520 THE FORMATTING OF THE DATA 3261 02:23:54,520 --> 02:23:57,080 DOESN'T EASILY LEND ITSELF TO 3262 02:23:57,080 --> 02:24:00,800 PUT DATA TOGETHER. 3263 02:24:00,800 --> 02:24:03,320 ALSO ANOTHER KEY LIMITATION IS 3264 02:24:03,320 --> 02:24:04,880 DRAWING INFORMATION FROM 3265 02:24:04,880 --> 02:24:05,800 MULTIPLE SOURCES SOMETIMES IS 3266 02:24:05,800 --> 02:24:06,880 HARD. 3267 02:24:06,880 --> 02:24:09,040 DEPENDING ON THE DATA TYPE AND 3268 02:24:09,040 --> 02:24:10,160 MAYBE DIFFERENT AGREEMENTS THAT 3269 02:24:10,160 --> 02:24:11,360 NEED TO BE PUT INTO PLACE. 3270 02:24:11,360 --> 02:24:14,160 OR EVEN IF THE DATA IS PUBLIC 3271 02:24:14,160 --> 02:24:15,840 SOMETIMES YOU STILL NEED TO HAVE 3272 02:24:15,840 --> 02:24:18,080 ACCESS CONTROLS. 3273 02:24:18,080 --> 02:24:24,120 YOU STILL NEED TO GO THROUGH 3274 02:24:24,120 --> 02:24:25,240 SOME PAPERWORK AND SUBMISSIONS. 3275 02:24:25,240 --> 02:24:27,160 SO WHAT IS NEEDED REALLY IS TO 3276 02:24:27,160 --> 02:24:31,440 BUILD OFF WHAT IS KNOWN. 3277 02:24:31,440 --> 02:24:34,000 YOU HAVE ACCESS TO 3278 02:24:34,000 --> 02:24:35,400 INTERPRETATIONS WE CAN BETTER 3279 02:24:35,400 --> 02:24:37,240 UNDERSTAND WHAT THEY MEAN BASED 3280 02:24:37,240 --> 02:24:37,840 ON PRIOR KNOWLEDGE. 3281 02:24:37,840 --> 02:24:41,720 SO THE IDEA IS TO UPON EXISTING 3282 02:24:41,720 --> 02:24:43,720 KNOWLEDGE AND OVERLAY NEW DATA. 3283 02:24:43,720 --> 02:24:52,800 HOW DO WE DO THIS? 3284 02:24:52,800 --> 02:24:54,640 WE DO THIS BY CONNECTING 3285 02:24:54,640 --> 02:24:57,040 DIFFERENT TYPES OF DATA AND 3286 02:24:57,040 --> 02:25:01,040 DEVELOPING ALGORITHMS AND 3287 02:25:01,040 --> 02:25:02,080 MACHINE LEARNING TOOLS AND 3288 02:25:02,080 --> 02:25:02,960 METHODS. 3289 02:25:02,960 --> 02:25:03,400 I'LL GIVE EXAMPLES. 3290 02:25:03,400 --> 02:25:06,080 WE'LL START WITH STANDARDS AND 3291 02:25:06,080 --> 02:25:06,480 INTEROPERABILITY. 3292 02:25:06,480 --> 02:25:10,040 AND THE EXAMPLE I WANT TO GIVE 3293 02:25:10,040 --> 02:25:14,080 HERE STANDARDIZATION OF 3294 02:25:14,080 --> 02:25:15,200 MEDICINAL PRODUCTS. 3295 02:25:15,200 --> 02:25:20,040 SO THE GLOBAL SUBSTANCE 3296 02:25:20,040 --> 02:25:22,000 REGISTRATION SYSTEM, GSRS WAS 3297 02:25:22,000 --> 02:25:26,080 IMPLEMENTED AND THIS IS A 3298 02:25:26,080 --> 02:25:28,000 COLLABORATION WITH THE FDA. 3299 02:25:28,000 --> 02:25:32,000 THIS PROVIDES PUBLIC ACCESS TO 3300 02:25:32,000 --> 02:25:35,600 DATA ON SUBSTANCES FOUND IN 3301 02:25:35,600 --> 02:25:36,040 MEDICINAL PRODUCTS. 3302 02:25:36,040 --> 02:25:38,600 THOSE INCLUDE SMALL MOLECULES 3303 02:25:38,600 --> 02:25:43,800 AND ALSO INCLUDE ANTIBODIES, 3304 02:25:43,800 --> 02:25:45,080 THERAPIES, ETCETERA. 3305 02:25:45,080 --> 02:25:49,160 AND THIS IS ACTUALLY THE FIRST 3306 02:25:49,160 --> 02:25:52,080 SYSTEM THAT IS 0133 STANDARD 3307 02:25:52,080 --> 02:25:53,760 COMPLIANCE AND THIS IS DATA TO 3308 02:25:53,760 --> 02:25:55,400 BE ABLE TO TRACK AND MAKE SURE 3309 02:25:55,400 --> 02:25:57,240 IF YOU'RE CALLING THIS MOLECULE 3310 02:25:57,240 --> 02:25:58,840 X, IT'S THE SAME MOLECULE X 3311 02:25:58,840 --> 02:26:01,440 SOMEBODY ELSE IS LOOKING AT THAT 3312 02:26:01,440 --> 02:26:01,680 MOLECULE. 3313 02:26:01,680 --> 02:26:03,000 IT'S REALLY MAKING THE 3314 02:26:03,000 --> 02:26:06,040 CONNECTION AND ALL THE IS 3315 02:26:06,040 --> 02:26:09,160 CURATED BY THE FDA. 3316 02:26:09,160 --> 02:26:12,160 THIS OFFER HAS TAKEN OFF AND 3317 02:26:12,160 --> 02:26:13,120 THERE'S NOW BROAD ADOPTION 3318 02:26:13,120 --> 02:26:14,920 BEYOND THE FDA. 3319 02:26:14,920 --> 02:26:19,760 WE ALSO USE IT INTERNALLY AT 3320 02:26:19,760 --> 02:26:20,080 NCATS. 3321 02:26:20,080 --> 02:26:23,400 BUT IT'S ALSO ADOPTED BY THE 3322 02:26:23,400 --> 02:26:33,040 W.H.O. AND THE EUROPEAN AGENCY 3323 02:26:33,040 --> 02:26:41,440 AND UNITED STATES PHARMACOPEIA 3324 02:26:41,440 --> 02:26:42,520 AND LEVERAGE THE INFRASTRUCTURE 3325 02:26:42,520 --> 02:26:43,680 IN DIFFERENT REGULATORY AGENCIES 3326 02:26:43,680 --> 02:26:44,600 AND WITHIN INDUSTRY. 3327 02:26:44,600 --> 02:26:50,080 YOU CAN SEE A SNAPSHOT OF WHAT 3328 02:26:50,080 --> 02:26:54,960 IT LOOKS LIKE ON THE RIGHT WE 3329 02:26:54,960 --> 02:26:57,000 HAVE A NICE REGISTRATION SYSTEM 3330 02:26:57,000 --> 02:26:59,560 AND YOU CAN BROWSE THE MOLECULES 3331 02:26:59,560 --> 02:27:00,200 BUT SOMETIMES THERE'S 3332 02:27:00,200 --> 02:27:02,720 INFORMATION THAT MAY BE MISSING. 3333 02:27:02,720 --> 02:27:04,880 FOR EXAMPLE, KEY DATA OR OTHER 3334 02:27:04,880 --> 02:27:06,080 BIOLOGICAL ACTIVITY OR OTHER 3335 02:27:06,080 --> 02:27:09,040 TYPES OF CLINICAL USES AND SO 3336 02:27:09,040 --> 02:27:14,040 HERE WE'VE DEVELOPED INSIGHT TO 3337 02:27:14,040 --> 02:27:16,320 DRUGS AND THIS CONTAINS CURATED 3338 02:27:16,320 --> 02:27:16,880 INFORMATION FROM THE FDA THROUGH 3339 02:27:20,720 --> 02:27:22,840 GSRX AND CONTAINS PUBLIC 3340 02:27:22,840 --> 02:27:24,920 INFORMATION DRAWN FROM REPUTABLE 3341 02:27:24,920 --> 02:27:27,080 RESOURCES AND ALSO DATA FROM 3342 02:27:27,080 --> 02:27:27,880 PRIVATE COMPANIES. 3343 02:27:27,880 --> 02:27:32,120 THIS DATA IS CURATED AND SERVED 3344 02:27:32,120 --> 02:27:34,920 IN THIS APPLICATION THAT YOU SEE 3345 02:27:34,920 --> 02:27:35,120 HERE. 3346 02:27:35,120 --> 02:27:38,600 AND THEN OF COURSE THIS DATA CAN 3347 02:27:38,600 --> 02:27:42,760 BE BROWSED AND USED IN OTHER 3348 02:27:42,760 --> 02:27:44,760 RESOURCES AND WE'RE WORKING ON 3349 02:27:44,760 --> 02:27:46,640 ENHANCING THE INTEROPERABILITY 3350 02:27:46,640 --> 02:27:48,560 SO PEOPLE CAN GET ACCESS TO ALL 3351 02:27:48,560 --> 02:27:49,160 THE DATA. 3352 02:27:49,160 --> 02:27:50,080 RIGHT NOW THEY HAVE ACCESS TO 3353 02:27:50,080 --> 02:27:55,400 ONLY SOME. 3354 02:27:55,400 --> 02:27:57,720 SO I GIVE YOU TWO EXAMPLES. 3355 02:27:57,720 --> 02:27:58,640 WE ACTUALLY HAVE QUITE A BIT 3356 02:27:58,640 --> 02:28:02,280 MORE AND SOME OF THEM ARE LISTED 3357 02:28:02,280 --> 02:28:03,440 HERE. 3358 02:28:03,440 --> 02:28:07,800 SO WE HAVE DATA AND APPLICATIONS 3359 02:28:07,800 --> 02:28:09,400 FOR INFORMATION RELATED TO DRUGS 3360 02:28:09,400 --> 02:28:11,400 AND DRUG SUBSTANCES. 3361 02:28:11,400 --> 02:28:19,960 I MENTIONED METABOLISM AND WE 3362 02:28:19,960 --> 02:28:22,080 WORK CLOSELY WITH THE DIVISION 3363 02:28:22,080 --> 02:28:26,080 OF CLINICAL INNOVATION AND THE 3364 02:28:26,080 --> 02:28:27,160 EXTRAMURAL DIVISION ON GUARD AND 3365 02:28:27,160 --> 02:28:28,320 HAVE A RARE DISEASE ALERT SYSTEM 3366 02:28:28,320 --> 02:28:30,520 WHICH IS NEW. 3367 02:28:30,520 --> 02:28:34,160 WE HAVE INFORMATION ON ASSAYS. 3368 02:28:34,160 --> 02:28:38,880 SO WE WORK WITH NLM AND THE OPEN 3369 02:28:38,880 --> 02:28:48,080 DATA PORTAL AND FINALLY ALL OF 3370 02:28:48,080 --> 02:28:49,840 THE EXCEPT THE OPEN DATA PORTAL 3371 02:28:49,840 --> 02:28:56,280 HAVE COME AND GUARD ARE LED BY 3372 02:28:56,280 --> 02:28:58,760 IFX AND NOW AGAIN GOING BACK TO 3373 02:28:58,760 --> 02:29:01,320 THE BIGGER VISION WE HAVE A LOT 3374 02:29:01,320 --> 02:29:03,080 OF DATA AT OUR DISPOSAL. 3375 02:29:03,080 --> 02:29:04,320 WE UNDERSTAND THE DATA VERY WELL 3376 02:29:04,320 --> 02:29:07,000 BECAUSE WE'RE THE ONES PUTTING 3377 02:29:07,000 --> 02:29:07,880 IT TOGETHER. 3378 02:29:07,880 --> 02:29:09,480 WE'RE INVOLVED IN PUTTING IT 3379 02:29:09,480 --> 02:29:09,960 TOGETHER. 3380 02:29:09,960 --> 02:29:10,560 SO HOW DO WE NAVIGATE THROUGH 3381 02:29:10,560 --> 02:29:11,680 IT? 3382 02:29:11,680 --> 02:29:14,120 SO LET ME SHOW YOU AN EXAMPLE IN 3383 02:29:14,120 --> 02:29:21,480 THE RARE DISEASE SPACE. 3384 02:29:21,480 --> 02:29:23,160 HERE WE ARE AIMING TO CLUSTER 3385 02:29:23,160 --> 02:29:24,640 RARE DISEASES AND WE WANT TO DO 3386 02:29:24,640 --> 02:29:25,960 THIS BECAUSE WE WANT TO FIND 3387 02:29:25,960 --> 02:29:27,520 SHARED CHARACTERISTICS. 3388 02:29:27,520 --> 02:29:29,160 AND WITH THE SHARED 3389 02:29:29,160 --> 02:29:30,080 CHARACTERISTICS WE CAN 3390 02:29:30,080 --> 02:29:31,000 POTENTIALLY FIND SHARED TARGETS 3391 02:29:31,000 --> 02:29:34,320 AND SHARED INTERVENTION. 3392 02:29:34,320 --> 02:29:36,200 RATHER THAN LOOKING AT ONE 3393 02:29:36,200 --> 02:29:38,760 DISEASE AT A TIME WE WANT TO 3394 02:29:38,760 --> 02:29:39,680 LOOK AT CLUSTERS AT A TIME. 3395 02:29:39,680 --> 02:29:42,840 HOW DO WE CLUSTER THEM ? 3396 02:29:42,840 --> 02:29:44,720 WE PUT DIFFERENT KINDS OF 3397 02:29:44,720 --> 02:29:46,440 INFORMATION TOGETHER IN THIS 3398 02:29:46,440 --> 02:29:49,720 CASE WE HAVE INFORMATION THAT 3399 02:29:49,720 --> 02:29:52,440 COMES FROM OUR OWN RESOURCES BUT 3400 02:29:52,440 --> 02:29:57,560 IT'S ALSO SUPPLEMENTED BY 3401 02:29:57,560 --> 02:30:00,640 OUTSIDE RESOURCES SUCH AS 3402 02:30:00,640 --> 02:30:02,440 PATHWAY COMMONS AND CREATE AN 3403 02:30:02,440 --> 02:30:03,080 INTEGRATED NETWORK. 3404 02:30:03,080 --> 02:30:09,080 THIS REFLECTS MOLECULAR 3405 02:30:09,080 --> 02:30:10,120 MECHANISMS AND ALSO VARIOUS 3406 02:30:10,120 --> 02:30:15,640 TYPES OF PHENOTYPES. 3407 02:30:15,640 --> 02:30:18,080 SO WE EMPLOYED A NATURAL 3408 02:30:18,080 --> 02:30:20,360 LANGUAGE ALGORITHM TO DEFINE 3409 02:30:20,360 --> 02:30:22,120 CLUSTERS YOU CAN SEE ON THE Y 3410 02:30:22,120 --> 02:30:24,840 AXIS SO EACH ROW HERE SAY 3411 02:30:24,840 --> 02:30:27,160 CLUSTER AND ON THE X AXIS 3412 02:30:27,160 --> 02:30:32,280 THERE'S CHARACTERISTIC THAT ARE 3413 02:30:32,280 --> 02:30:32,720 DRAWN. 3414 02:30:32,720 --> 02:30:34,960 IF YOU ZOOM INTO ONE ROW HERE 3415 02:30:34,960 --> 02:30:37,680 YOU CAN SEE THEY'RE SHARING THE 3416 02:30:37,680 --> 02:30:41,120 RED AND BLUE COLOR AND THOSE 3417 02:30:41,120 --> 02:30:42,840 MEASURE THE IMPACT OF THOSE 3418 02:30:42,840 --> 02:30:44,520 SPECIFIC CHARACTERISTICS. 3419 02:30:44,520 --> 02:30:47,560 THE CHARACTERISTICS ON MOLECULAR 3420 02:30:47,560 --> 02:30:49,440 MECHANISM OR DIFFERENT TYPES OF 3421 02:30:49,440 --> 02:30:49,760 PHENOTYPES. 3422 02:30:49,760 --> 02:30:52,280 AS AN EXAMPLE I WANT TO 3423 02:30:52,280 --> 02:30:57,600 HIGHLIGHT ONE OF THE CLUSTERS. 3424 02:30:57,600 --> 02:31:08,000 THE CLUSTER CONTAINS 3425 02:31:08,400 --> 02:31:14,080 CLARCOT-MARIE TOOTH AND 3426 02:31:14,080 --> 02:31:17,600 METATROPIC DYSPLASIA AND THEY 3427 02:31:17,600 --> 02:31:20,160 SHARE KEY CHARACTERISTICS AND I 3428 02:31:20,160 --> 02:31:21,920 LISTED SOME HERE INCLUDING 3429 02:31:21,920 --> 02:31:25,200 MUSCLE FILL AMOUNT SLIDING OR 3430 02:31:25,200 --> 02:31:26,200 MUSCLE ORGAN DEVELOPMENT AND 3431 02:31:26,200 --> 02:31:26,640 ORGANIZATION. 3432 02:31:26,640 --> 02:31:28,280 THIS IS IMPORTANT BECAUSE NOW WE 3433 02:31:28,280 --> 02:31:30,120 HAVE THE SHARED CHARACTERISTICS 3434 02:31:30,120 --> 02:31:35,440 AND WE CAN START LOOKING FOR 3435 02:31:35,440 --> 02:31:37,400 APPROPRIATE WAYS OF INTERVENING 3436 02:31:37,400 --> 02:31:39,000 INTO THE PATHWAYS AND TARGETING 3437 02:31:39,000 --> 02:31:39,200 THEM. 3438 02:31:39,200 --> 02:31:40,840 THIS IS THE NEXT STEP. 3439 02:31:40,840 --> 02:31:45,880 SO THIS WORK IS LAYING A 3440 02:31:45,880 --> 02:31:49,120 FOUNDATION FOR MANY FUTURE WORK 3441 02:31:49,120 --> 02:31:49,480 SO STAY TUNED. 3442 02:31:49,480 --> 02:31:51,760 ANOTHER EXAMPLE I'D LIKE TO 3443 02:31:51,760 --> 02:31:53,520 HIGHLIGHT IS THE NCATS 3444 02:31:53,520 --> 02:31:53,800 TRANSLATOR. 3445 02:31:53,800 --> 02:31:58,080 THIS IS A LARGE EFFORT THAT IS 3446 02:31:58,080 --> 02:32:07,600 LED BY THE EXTRAMURAL PROGRAM AT 3447 02:32:07,600 --> 02:32:08,960 NCATS AND AGGREGATES INFORMATION 3448 02:32:08,960 --> 02:32:11,280 ACROSS THE SPECTRUM FROM BASIC 3449 02:32:11,280 --> 02:32:14,600 TO RESEARCH TO CLINICAL. 3450 02:32:14,600 --> 02:32:17,960 AND THIS IS A LARGE 3451 02:32:17,960 --> 02:32:18,560 COLLABORATIVE EFFORT. 3452 02:32:18,560 --> 02:32:20,480 WE'RE INVOLVED AND MANY NUMEROUS 3453 02:32:20,480 --> 02:32:22,360 ACADEMIC INSTITUTIONS ARE AS 3454 02:32:22,360 --> 02:32:22,560 WELL. 3455 02:32:22,560 --> 02:32:27,080 AND VERY RECENTLY WE SEE HERE ON 3456 02:32:27,080 --> 02:32:29,640 THE RIGHT AN EXAMPLE OF THE 3457 02:32:29,640 --> 02:32:32,000 ASSAY AND YOU CAN QUERY 3458 02:32:32,000 --> 02:32:32,360 TRANSLATOR. 3459 02:32:32,360 --> 02:32:33,640 SO THERE'S SPECIFIC TYPES OF 3460 02:32:33,640 --> 02:32:36,040 QUERIES YOU CAN MAKE. 3461 02:32:36,040 --> 02:32:41,920 ONE I'D MAKE HERE IS ON GLIAL 3462 02:32:41,920 --> 02:32:44,920 BLASTOMA AND WE'RE LOOKING FOR 3463 02:32:44,920 --> 02:32:46,360 PUNITIVE TARGETS OF GLIAL 3464 02:32:46,360 --> 02:32:50,080 BLASTOMA AND WANTED TO COMPARE 3465 02:32:50,080 --> 02:32:51,800 THE TRANSLATOR. 3466 02:32:51,800 --> 02:32:55,200 AND WHEN I LOOK HERE FOR ONE 3467 02:32:55,200 --> 02:32:57,200 DRUG MAY TREAT GLIAL BLASTOMA, 3468 02:32:57,200 --> 02:33:00,480 WHAT GETS RETURNED IS NOT ONLY A 3469 02:33:00,480 --> 02:33:05,640 LIST OF DRUGS BUT ALSO TELLS YOU 3470 02:33:05,640 --> 02:33:08,880 WHY IT FOUND THOSE PARTICULAR 3471 02:33:08,880 --> 02:33:09,080 DRUGS. 3472 02:33:09,080 --> 02:33:10,880 SO THE FIRST HIT HERE IS IF YOU 3473 02:33:10,880 --> 02:33:13,360 LOOK HERE ON THE BOTTOM YOU CAN 3474 02:33:13,360 --> 02:33:16,080 SEE THAT THE DRUG IN YELLOW 3475 02:33:16,080 --> 02:33:19,560 LINKED TO THE DISEASE GLIAL 3476 02:33:19,560 --> 02:33:22,480 BLASTOMA IN BLUE AND WHY THEY'RE 3477 02:33:22,480 --> 02:33:23,320 CONNECTED. 3478 02:33:23,320 --> 02:33:26,080 AND WHAT'S MOST INTERESTING 3479 02:33:26,080 --> 02:33:31,520 ARGUABLY HERE IS THE 3480 02:33:31,520 --> 02:33:35,280 RELATIONSHIP WITH THE KINASE 3481 02:33:35,280 --> 02:33:38,080 WHICH IT TARGETS AND THIS IS 3482 02:33:38,080 --> 02:33:39,360 ASSOCIATED WITH GLIAL BLASTOMA 3483 02:33:39,360 --> 02:33:42,080 AND SOMETHING WE FOUND IN OUR 3484 02:33:42,080 --> 02:33:43,440 OTHER STUDY IN THE SIMILAR 3485 02:33:43,440 --> 02:33:48,000 INDIRECT WAY AND LOOKING AT 3486 02:33:48,000 --> 02:33:51,040 CLINICAL TRIALS THERE'S A HUGE 3487 02:33:51,040 --> 02:33:54,040 CLINICAL TRIALS EVALUATING FOR 3488 02:33:54,040 --> 02:33:56,280 THE GLIAL BLASTOMA. 3489 02:33:56,280 --> 02:34:00,400 THIS IS HOW WE FIT THIS TYPE OF 3490 02:34:00,400 --> 02:34:00,960 INFORMATION. 3491 02:34:00,960 --> 02:34:03,080 ONE ASPECT IS TRUSTWORTHINESS IN 3492 02:34:03,080 --> 02:34:07,680 THE RESULTS. 3493 02:34:07,680 --> 02:34:09,120 WITH CHAT GPT AND THE SOFTWARE 3494 02:34:09,120 --> 02:34:12,880 THAT ARE REALLY AT OUR FINGER 3495 02:34:12,880 --> 02:34:14,080 TIPS DON'T REALLY PROVIDE 3496 02:34:14,080 --> 02:34:16,000 INFORMATION HOW THEY GOT TO 3497 02:34:16,000 --> 02:34:18,800 THEIR ANSWERS. 3498 02:34:18,800 --> 02:34:20,960 BUT YOU HAVE TO MAKE SURE THE 3499 02:34:20,960 --> 02:34:22,520 ANSWERS ARE THEMSELVES 3500 02:34:22,520 --> 02:34:23,640 TRUSTWORTHY AND THERE'S 3501 02:34:23,640 --> 02:34:26,040 TRANSPARENCY IN THAT THROUGH 3502 02:34:26,040 --> 02:34:28,040 TRANSLATOR AND ALSO THROUGH THE 3503 02:34:28,040 --> 02:34:28,880 KNOWLEDGE GRAPHS WE BUILD IN 3504 02:34:28,880 --> 02:34:33,080 GENERAL AND I THINK IT'S A VERY 3505 02:34:33,080 --> 02:34:36,800 KEY POINT. 3506 02:34:36,800 --> 02:34:38,400 LASTLY I WANT TO TALK A LITTLE 3507 02:34:38,400 --> 02:34:40,400 BIT ABOUT NEW TECHNOLOGIES WE'RE 3508 02:34:40,400 --> 02:34:42,160 BRINGING HERE AT NCATS 3509 02:34:42,160 --> 02:34:45,440 SPECIFICALLY RELATED TO OMICS. 3510 02:34:45,440 --> 02:34:48,520 AND SO THE OMICS IS VERY 3511 02:34:48,520 --> 02:34:50,800 IMPORTANT BECAUSE IT ENABLES THE 3512 02:34:50,800 --> 02:34:53,800 COMPREHENSIVE PROFILING OF 3513 02:34:53,800 --> 02:34:57,080 METABOLITES, GENES AND PROTEINS 3514 02:34:57,080 --> 02:34:58,040 AND THOSE ARE IMPORTANT FOR 3515 02:34:58,040 --> 02:34:59,040 DISCOVERING BIOMARKERS AND 3516 02:34:59,040 --> 02:35:00,880 IDENTIFYING THE MECHANISMS THAT 3517 02:35:00,880 --> 02:35:02,080 UNDER LIE DISEASES AND DRUG 3518 02:35:02,080 --> 02:35:05,880 RESPONSE. 3519 02:35:05,880 --> 02:35:08,280 AND SO WE'RE VERY INVOLVED THE 3520 02:35:08,280 --> 02:35:09,840 ROBUST DATA GENERATION INCLUDING 3521 02:35:09,840 --> 02:35:13,800 STUDY DESIGN AND WE'RE ALSO 3522 02:35:13,800 --> 02:35:14,720 DEVELOPING RECRUITING PROTOCOLS 3523 02:35:14,720 --> 02:35:16,840 AT SCALE AND WE'RE DOING THIS 3524 02:35:16,840 --> 02:35:17,760 WITH METABOLOMICS. 3525 02:35:17,760 --> 02:35:22,040 THIS IS AN EXAMPLE OF A RECENT 3526 02:35:22,040 --> 02:35:24,360 INSTRUMENT THAT WE'VE ACQUIRED 3527 02:35:24,360 --> 02:35:27,080 WITH OUR IN-HOUSE COLLABORATORS 3528 02:35:27,080 --> 02:35:27,960 IN ANALYTICAL CHEMISTRY. 3529 02:35:27,960 --> 02:35:34,840 THE REASON TO DO THIS IS BECAUSE 3530 02:35:34,840 --> 02:35:36,680 NCATS TENDS TO DO THINGS AT 3531 02:35:36,680 --> 02:35:39,720 SCALE AND VERY COSTLY TO DO THIS 3532 02:35:39,720 --> 02:35:41,280 AT SCALE IF WE SHIP OUT THE 3533 02:35:41,280 --> 02:35:42,200 SAMPLES FOR THAT ANALYSIS. 3534 02:35:42,200 --> 02:35:44,200 SO WE WANT TO BRING THIS 3535 02:35:44,200 --> 02:35:45,840 IN-HOUSE TO BE ABLE TO DO IT. 3536 02:35:45,840 --> 02:35:50,760 AND THEN IN PARALLEL, WE'RE ABLE 3537 02:35:50,760 --> 02:35:54,080 TO ALSO PRODUCE THE ROBUST DATA 3538 02:35:54,080 --> 02:35:56,400 ANALYTICS AND THIS INCLUDES 3539 02:35:56,400 --> 02:35:58,560 NOVEL METHODOLOGY BUT THOSE TWO 3540 02:35:58,560 --> 02:36:01,560 GO HAND IN HAND AND THIS IS A 3541 02:36:01,560 --> 02:36:02,040 TREND. 3542 02:36:02,040 --> 02:36:03,480 PEOPLE THINK OF THE DATA 3543 02:36:03,480 --> 02:36:05,040 GENERATION AND GET TO A POINT 3544 02:36:05,040 --> 02:36:06,600 WHERE THERE'S A LOT OF DATA AND 3545 02:36:06,600 --> 02:36:08,840 WHAT ARE WE GOING TO DO WITH IT 3546 02:36:08,840 --> 02:36:10,000 AND BUILD THE INFRASTRUCTURE. 3547 02:36:10,000 --> 02:36:11,760 HERE WE'RE SPOILED IN THAT WE'RE 3548 02:36:11,760 --> 02:36:13,800 ABLE TO DO BOTH IN PARALLEL AT 3549 02:36:13,800 --> 02:36:14,360 THE SAME TIME. 3550 02:36:14,360 --> 02:36:17,880 WE'RE SETTING OURSELVES UP TO BE 3551 02:36:17,880 --> 02:36:19,760 ABLE TO HANDLE THE BIG DATA ONCE 3552 02:36:19,760 --> 02:36:22,120 IT COMES AND WE'RE ALSO MAKING 3553 02:36:22,120 --> 02:36:26,080 SURE THAT ALL THESE ANALYTICS 3554 02:36:26,080 --> 02:36:28,800 ARE INTEROPERABLE WITH OTHER 3555 02:36:28,800 --> 02:36:32,000 DATA TYPES BEING GENERATED AT 3556 02:36:32,000 --> 02:36:35,240 NCATS INCLUDING THE IMAGING 3557 02:36:35,240 --> 02:36:36,040 DATA. 3558 02:36:36,040 --> 02:36:37,360 WE'RE ALL IN COMMUNICATION TO BE 3559 02:36:37,360 --> 02:36:46,880 AS 3560 02:36:46,880 --> 02:36:49,040 ANOTHER WORK WE'RE DOING TO 3561 02:36:49,040 --> 02:36:52,000 HOUSE MOLECULAR DATA UNDER ONE 3562 02:36:52,000 --> 02:36:53,640 SYSTEM TO FACILITATE THE REUSE. 3563 02:36:53,640 --> 02:36:56,280 RIGHT NOW THERE'S NO PUBLIC 3564 02:36:56,280 --> 02:36:58,480 MULTIOMIC REPOSITORY THAT EXISTS 3565 02:36:58,480 --> 02:36:59,440 THAT INCLUDES THE ANALYTICS, SO 3566 02:36:59,440 --> 02:37:03,040 YOU MAY BE ABLE TO GET ACCESS TO 3567 02:37:03,040 --> 02:37:05,240 DATA, BUT YOU STILL HAVE TO DO 3568 02:37:05,240 --> 02:37:06,640 THE WORK TO PUT IT TOGETHER. 3569 02:37:06,640 --> 02:37:08,760 AND YOU STILL HAVE TO HAVE THE 3570 02:37:08,760 --> 02:37:10,400 ANALYTICS AND THAT KNOWLEDGE IN 3571 02:37:10,400 --> 02:37:10,960 HOUSE. 3572 02:37:10,960 --> 02:37:13,680 WE HAVE A COUPLE GUIDING 3573 02:37:13,680 --> 02:37:15,480 PRINCIPLES THAT WE'RE APPLYING 3574 02:37:15,480 --> 02:37:17,280 AS WE'RE DEVELOPING THIS. 3575 02:37:17,280 --> 02:37:22,720 WE WANT TO USE STANDARD DATA 3576 02:37:22,720 --> 02:37:24,400 FORMATS, AND STANDARD 3577 02:37:24,400 --> 02:37:25,040 PRE-PROCESSING. 3578 02:37:25,040 --> 02:37:26,720 WE WANT A DIRECT ACCESS TO 3579 02:37:26,720 --> 02:37:28,680 ANALYTICS TO ANALYZE THE DATA. 3580 02:37:28,680 --> 02:37:31,680 WE WANT IT TO BE INTEROPERABLE 3581 02:37:31,680 --> 02:37:33,360 WITH OTHER NCATS RESOURCES. 3582 02:37:33,360 --> 02:37:35,600 BOTTOM LEFT, AGAIN, BEING ABLE 3583 02:37:35,600 --> 02:37:37,600 TO LOOK AT THAT MEDIA GENERATED 3584 02:37:37,600 --> 02:37:38,440 IN LIGHT OF THE PREVIOUS 3585 02:37:38,440 --> 02:37:40,200 KNOWLEDGE FROM THE KNOWLEDGE 3586 02:37:40,200 --> 02:37:44,240 SOURCES, THAT WE'VE BEEN 3587 02:37:44,240 --> 02:37:44,760 BUILDING. 3588 02:37:44,760 --> 02:37:46,760 HERE THE SCIENTIFIC GOAL IS 3589 02:37:46,760 --> 02:37:48,720 BRIDGE THE GAP BETWEEN 3590 02:37:48,720 --> 02:37:50,360 PRE-CLINICAL AND CLINICAL 3591 02:37:50,360 --> 02:37:52,920 EFFORT, TRY TO DERIVE ACTIONABLE 3592 02:37:52,920 --> 02:37:54,200 INSIGHTS FROM THE DATA. 3593 02:37:54,200 --> 02:37:57,720 ON THE TOP RIGHT THIS IS JUST 3594 02:37:57,720 --> 02:38:01,680 OUR INTERFACE RIGHT NOW, IT'S IN 3595 02:38:01,680 --> 02:38:01,960 DEVELOPMENT. 3596 02:38:01,960 --> 02:38:05,600 IT MAY CHANGE. 3597 02:38:05,600 --> 02:38:07,040 SO, OVERALL, YOU KNOW, IT'S 3598 02:38:07,040 --> 02:38:10,640 ABOUT TURNING DATA INTO 3599 02:38:10,640 --> 02:38:11,400 ACTIONABLE INSIGHT, ACCELERATING 3600 02:38:11,400 --> 02:38:12,400 TRANSLATION AND FINDINGS TO THE 3601 02:38:12,400 --> 02:38:12,640 CLINIC. 3602 02:38:12,640 --> 02:38:16,840 A LOT OF DATA IS COMING OUR WAY, 3603 02:38:16,840 --> 02:38:18,040 INTERPRETATION IS VERY 3604 02:38:18,040 --> 02:38:20,600 DIFFICULT, BUT WE'RE PUTTING THE 3605 02:38:20,600 --> 02:38:24,080 TOOLS TOGETHER TO BE ABLE TO 3606 02:38:24,080 --> 02:38:26,520 MAKE THAT INTERPRETATION 3607 02:38:26,520 --> 02:38:26,880 EFFICIENT. 3608 02:38:26,880 --> 02:38:31,800 AND ALSO ABLE TO MAKE IT AS 3609 02:38:31,800 --> 02:38:32,920 ROBUST AS POSSIBLE. 3610 02:38:32,920 --> 02:38:38,160 WE'RE REALLY ABLE TO DO THIS 3611 02:38:38,160 --> 02:38:39,840 THROUGH TEAM SCIENCE CULTURE, WE 3612 02:38:39,840 --> 02:38:42,000 HAVE THE CULTURE BUT IT 3613 02:38:42,000 --> 02:38:44,280 PERMEATES THROUGHOUT NCATS. 3614 02:38:44,280 --> 02:38:45,320 AND THAT MULTI-LINGUAL ASPECT OF 3615 02:38:45,320 --> 02:38:49,880 OUR TEAM THAT WE'RE ABLE TO TOSS 3616 02:38:49,880 --> 02:38:50,840 TO DIFFERENT EXPERTS, CHEMISTRY, 3617 02:38:50,840 --> 02:38:51,880 BIOLOGY, ET CETERA. 3618 02:38:51,880 --> 02:38:55,480 WE HAVE A LOT OF COLLABORATIONS 3619 02:38:55,480 --> 02:38:57,560 WITHIN NCATS, MORE BROADLY AT 3620 02:38:57,560 --> 02:39:00,200 THE NIH. 3621 02:39:00,200 --> 02:39:00,920 MANY REGULATORY AGENCIES, 3622 02:39:00,920 --> 02:39:02,040 ACADEMIA, ALSO SOME IN INDUSTRY. 3623 02:39:02,040 --> 02:39:04,760 AND AT THE END OF THE DAY WE 3624 02:39:04,760 --> 02:39:06,720 WANT TO DERIVE ACTIONABLE 3625 02:39:06,720 --> 02:39:07,520 INSIGHTS THROUGH DATA 3626 02:39:07,520 --> 02:39:10,360 INTEGRATION AND BUILD ON WHAT WE 3627 02:39:10,360 --> 02:39:12,960 KNOW TO ENHANCE TRANSLATIONAL 3628 02:39:12,960 --> 02:39:13,960 SCIENCE EFFORTS. 3629 02:39:13,960 --> 02:39:17,600 SO, WITH THAT I HOPE YOU'RE AS 3630 02:39:17,600 --> 02:39:21,840 EXCITED AS I AM, AND OUR EFFORT 3631 02:39:21,840 --> 02:39:27,680 TO REALLY TRY TO MAKE THE VISION 3632 02:39:27,680 --> 02:39:29,280 A REALITY, PROVIDING MORE 3633 02:39:29,280 --> 02:39:31,680 TREATMENT TO MORE PATIENTS. 3634 02:39:31,680 --> 02:39:32,680 THIS IS OUR GROUP. 3635 02:39:32,680 --> 02:39:36,520 WE MET FOR THE FIRST TIME LAST 3636 02:39:36,520 --> 02:39:37,200 FALL. 3637 02:39:37,200 --> 02:39:38,520 SO, AS ANTON MENTIONED, WHEN I 3638 02:39:38,520 --> 02:39:42,080 CAME IN I ONLY HAD A MONTH AND A 3639 02:39:42,080 --> 02:39:43,760 HALF, A LOT OF PEOPLE I MET FOR 3640 02:39:43,760 --> 02:39:46,960 THE FIRST TIME LAST FALL, A BIT 3641 02:39:46,960 --> 02:39:47,480 FUNNY. 3642 02:39:47,480 --> 02:39:50,600 AND THANK YOU FOR YOUR 3643 02:39:50,600 --> 02:39:50,840 ATTENTION. 3644 02:39:50,840 --> 02:40:00,640 [APPLAUSE] 3645 02:40:00,640 --> 02:40:02,120 >> THANK YOU, EWY. 3646 02:40:02,120 --> 02:40:05,880 I WOULD LIKE TO SEE IF THERE ARE 3647 02:40:05,880 --> 02:40:07,400 ANY QUESTIONS FOR EWY AROUND THE 3648 02:40:07,400 --> 02:40:09,720 TABLE. 3649 02:40:09,720 --> 02:40:15,400 3650 02:40:15,400 --> 02:40:17,920 >> I DON'T HAVE A QUESTION. 3651 02:40:17,920 --> 02:40:20,120 I HAVE A COMMENT. 3652 02:40:20,120 --> 02:40:22,320 INFORMATICS IS NOT MY 3653 02:40:22,320 --> 02:40:24,400 WHEELHOUSE, BUT POLICY IS. 3654 02:40:24,400 --> 02:40:25,480 BEING AN END USER IN THE 3655 02:40:25,480 --> 02:40:27,760 COMMUNITY I CAN JUST SAY WE'VE 3656 02:40:27,760 --> 02:40:29,520 BEEN TALKING, WHEN WE DID THE 3657 02:40:29,520 --> 02:40:33,040 LAST TOUR, COVID LEARNINGS, HOW 3658 02:40:33,040 --> 02:40:38,600 WE'RE PULLING THEM BACK. 3659 02:40:38,600 --> 02:40:41,680 AND ONE OF THE THINGS IN THE 3660 02:40:41,680 --> 02:40:43,320 COMMUNITY FOR A VERY LONG TIME 3661 02:40:43,320 --> 02:40:46,640 WE'VE BEEN WANTING AND PUSHING 3662 02:40:46,640 --> 02:40:48,680 FOR, REAL WORLD DATA TO BE ABLE 3663 02:40:48,680 --> 02:40:51,760 TO INFORM DIFFERENT AREAS OF THE 3664 02:40:51,760 --> 02:40:52,960 ECOSYSTEM, ESPECIALLY LABEL 3665 02:40:52,960 --> 02:40:53,200 EXPANSION. 3666 02:40:53,200 --> 02:40:55,360 AND SO JUST SEEING HOW THAT 3667 02:40:55,360 --> 02:40:57,320 TECHNOLOGY IS BEING UTILIZED 3668 02:40:57,320 --> 02:40:59,280 HERE TO DO THAT, HAPPENING 3669 02:40:59,280 --> 02:41:01,920 WITHIN COVID BUT APPLICATIONS 3670 02:41:01,920 --> 02:41:05,520 BEYOND THAT, IT'S REALLY MUSIC 3671 02:41:05,520 --> 02:41:07,720 TO OUR EARS. 3672 02:41:07,720 --> 02:41:10,800 LANGUAGE IN THE 21ST CENTURY 3673 02:41:10,800 --> 02:41:12,480 CURES ACT, GUIDANCES HAVE COME 3674 02:41:12,480 --> 02:41:15,760 OUT OF FDA SHOWING THAT CAN BE 3675 02:41:15,760 --> 02:41:19,800 DONE BUT SEEING THAT PUT IN USE 3676 02:41:19,800 --> 02:41:21,880 WHEN NCATS AND FDA, CRITICAL 3677 02:41:21,880 --> 02:41:23,320 PATHS, IT'S REALLY WONDERFUL. 3678 02:41:23,320 --> 02:41:25,360 WE NEED MORE BUT TO SEE NCATS AT 3679 02:41:25,360 --> 02:41:26,800 THE CENTER AND HELPING DRIVE 3680 02:41:26,800 --> 02:41:28,120 THAT IS CRITICALLY IMPORTANT. 3681 02:41:28,120 --> 02:41:31,600 I JUST WANTED TO FLAG THAT AND 3682 02:41:31,600 --> 02:41:34,440 THANK YOU FOR THAT, PUSH 3683 02:41:34,440 --> 02:41:36,840 LANGUAGE INTO FEDORA TO MAKE 3684 02:41:36,840 --> 02:41:39,040 SURE EVERYONE THAT NEEDS TO HAS 3685 02:41:39,040 --> 02:41:40,440 EXPLICIT AUTHORITY TO DO THAT. 3686 02:41:40,440 --> 02:41:46,080 THANK YOU FOR YOUR WORK ON THAT. 3687 02:41:46,080 --> 02:41:48,400 >> IN A SHORT AMOUNT OF TIME, 3688 02:41:48,400 --> 02:41:50,280 THE PROGRESS, BUT A QUESTION IS, 3689 02:41:50,280 --> 02:41:59,120 WHAT IS THE PROTOCOL FOR THE 3690 02:41:59,120 --> 02:41:59,880 SCIENTIFIC COMMUNITY, WONDERFUL 3691 02:41:59,880 --> 02:42:01,840 CONTRIBUTION, LOTS OF PEOPLE 3692 02:42:01,840 --> 02:42:03,160 COULD BENEFIT FROM. 3693 02:42:03,160 --> 02:42:07,200 >> YEAH, SO RIGHT NOW IT'S 3694 02:42:07,200 --> 02:42:08,440 INTERNAL ONLY. 3695 02:42:08,440 --> 02:42:10,280 HOWEVER, THERE'S NO REASON WHY 3696 02:42:10,280 --> 02:42:12,600 IT COULD BE PUBLICLY RELEASED, 3697 02:42:12,600 --> 02:42:13,680 AND PROBABLY, YOU KNOW, ONE 3698 02:42:13,680 --> 02:42:15,600 MODEL THAT WE'VE BEEN THINKING 3699 02:42:15,600 --> 02:42:18,640 ABOUT IS SIMILAR TO THE GSRS 3700 02:42:18,640 --> 02:42:20,240 MODEL, WHERE YOU HAVE AN 3701 02:42:20,240 --> 02:42:23,640 INSTANCE OF THE SOFTWARE AT THE 3702 02:42:23,640 --> 02:42:28,120 FDA AND ANOTHER AT AREA 3703 02:42:28,120 --> 02:42:29,120 INSTITUTIONS, IT CHANGES 3704 02:42:29,120 --> 02:42:30,120 ACCORDING TO THEIR ENVIRONMENT, 3705 02:42:30,120 --> 02:42:33,160 AND THAT'S WHAT WE'RE THINKING 3706 02:42:33,160 --> 02:42:33,520 ABOUT. 3707 02:42:33,520 --> 02:42:37,640 BUT INITIALLY IT'S GOING TO BE 3708 02:42:37,640 --> 02:42:37,920 IN HOUSE. 3709 02:42:37,920 --> 02:42:46,840 BUT, YES, THAT'S WHERE WE'RE AT 3710 02:42:46,840 --> 02:42:47,600 RIGHT NOW. 3711 02:42:47,600 --> 02:42:47,880 >> MATTIAS? 3712 02:42:47,880 --> 02:42:51,800 >> ALWAYS GREAT TO SEE A 3713 02:42:51,800 --> 02:42:52,680 PARTNER BUILDING INFORMATICS 3714 02:42:52,680 --> 02:42:54,440 INFRASTRUCTURE FOR THE NEEDS OUT 3715 02:42:54,440 --> 02:42:54,840 THERE. 3716 02:42:54,840 --> 02:42:58,120 OBVIOUSLY, YOU HAVE A VERY 3717 02:42:58,120 --> 02:43:00,200 POWERFUL AND EFFECTIVE TEAM. 3718 02:43:00,200 --> 02:43:02,640 BUT NEVER INFORM INFORMATICIANS, 3719 02:43:02,640 --> 02:43:03,760 SOFTWARE DESIGNERS, PROJECT 3720 02:43:03,760 --> 02:43:05,920 MANAGERS TO DO THAT. 3721 02:43:05,920 --> 02:43:10,960 WHAT'S YOUR PROCESS TO IDENTIFY 3722 02:43:10,960 --> 02:43:12,360 AND PRIORITIZE TEAM BUILDING AND 3723 02:43:12,360 --> 02:43:18,840 AFTER YOU BUILD IT AND OBVIOUSLY 3724 02:43:18,840 --> 02:43:20,040 THE DESIGN PRINCIPLES, AFTER YOU 3725 02:43:20,040 --> 02:43:23,560 BUILD IT, HOW DO YOU MAINTAIN IT 3726 02:43:23,560 --> 02:43:27,840 AND KEEP IT ROBUST AND RESILIENT 3727 02:43:27,840 --> 02:43:28,920 TO THE USER? 3728 02:43:28,920 --> 02:43:30,680 >>I MEAN, YOU KNOW, THESE ARE 3729 02:43:30,680 --> 02:43:32,440 THE MILLION DOLLAR QUESTIONS, 3730 02:43:32,440 --> 02:43:32,920 RIGHT? 3731 02:43:32,920 --> 02:43:35,960 TRYING TO FIGURE OUT WHAT TO 3732 02:43:35,960 --> 02:43:38,120 PRIORITIZE AND WHAT TO MAINTAIN. 3733 02:43:38,120 --> 02:43:42,760 SO IN TERMS OF PRIORITIZATION, I 3734 02:43:42,760 --> 02:43:45,000 THINK THERE'S -- SOME OF THESE 3735 02:43:45,000 --> 02:43:47,640 PROJECTS ARE DRIVEN THROUGH 3736 02:43:47,640 --> 02:43:49,320 EXTRAMURAL FUNDS, AND SO THAT'S 3737 02:43:49,320 --> 02:43:51,280 HOW WE CAN KEEP DEVELOPING 3738 02:43:51,280 --> 02:43:51,480 THOSE. 3739 02:43:51,480 --> 02:43:54,760 OBVIOUSLY WHEN THEY REACH SUCH A 3740 02:43:54,760 --> 02:43:56,080 BROAD IMPASSE, ESPECIALLY 3741 02:43:56,080 --> 02:43:58,280 INTERNATIONALLY, THOSE ARE 3742 02:43:58,280 --> 02:43:59,480 DEFINITELY PROJECTS THAT WE WANT 3743 02:43:59,480 --> 02:44:04,160 TO, YOU KNOW, KEEP WORKING ON. 3744 02:44:04,160 --> 02:44:06,360 ON THE FLIP SIDE, YOU HAVE TO 3745 02:44:06,360 --> 02:44:08,200 HAVE THESE FRESH NEW IDEAS, 3746 02:44:08,200 --> 02:44:08,560 RIGHT? 3747 02:44:08,560 --> 02:44:10,400 ALWAYS NEW DATA IS BEING 3748 02:44:10,400 --> 02:44:10,840 GENERATED. 3749 02:44:10,840 --> 02:44:13,560 AND SO WE HAVE A NUMBER OF 3750 02:44:13,560 --> 02:44:14,480 TRAINEES THAT ARE DEVELOPING 3751 02:44:14,480 --> 02:44:16,400 KIND OF THESE NEW METHODS, 3752 02:44:16,400 --> 02:44:18,400 LOOKING AT NEW TECHNOLOGIES, 3753 02:44:18,400 --> 02:44:20,240 BRINGING IN THOSE FRESH IDEAS, 3754 02:44:20,240 --> 02:44:23,440 AND SOME OF THEM JUST STICK. 3755 02:44:23,440 --> 02:44:25,840 AND THEY STICK BECAUSE WHEN WE 3756 02:44:25,840 --> 02:44:27,480 TALK ABOUT THEM, THEN OTHERS 3757 02:44:27,480 --> 02:44:31,080 FIND USE CASES FOR THEM, RIGHT? 3758 02:44:31,080 --> 02:44:33,880 AND I THINK THE USE CASE IS 3759 02:44:33,880 --> 02:44:34,680 WHAT'S DRIVING OUR 3760 02:44:34,680 --> 02:44:35,080 PRIORITIZATION. 3761 02:44:35,080 --> 02:44:35,920 IF THERE'S MULTIPLE PEOPLE THAT 3762 02:44:35,920 --> 02:44:38,880 COME IN AND WE'RE LIKE, OH, THIS 3763 02:44:38,880 --> 02:44:40,720 IS SUPER USEFUL, MAYBE YOU CAN 3764 02:44:40,720 --> 02:44:43,160 ADD THIS FEATURE, THEN, YEAH, I 3765 02:44:43,160 --> 02:44:44,920 MEAN, WE'RE GOING TO PRIORITIZE 3766 02:44:44,920 --> 02:44:48,160 IT AND GET IT DONE BECAUSE 3767 02:44:48,160 --> 02:44:49,800 THAT'S HOW -- IT BECOMES A 3768 02:44:49,800 --> 02:44:52,800 SNOWBALL EFFECT, RIGHT? 3769 02:44:52,800 --> 02:44:55,640 WHEN USAGE GOES DOWN OR USE 3770 02:44:55,640 --> 02:44:56,960 CASES BECOME OBSOLETE THAT'S 3771 02:44:56,960 --> 02:44:57,960 WHEN WE DEPRIORITIZE. 3772 02:44:57,960 --> 02:45:00,480 THIS IS ALWAYS A WORK IN 3773 02:45:00,480 --> 02:45:00,840 PROGRESS. 3774 02:45:00,840 --> 02:45:02,880 NOBODY LIKES TO KILL PROJECTS. 3775 02:45:02,880 --> 02:45:07,360 WE HAVE WORKED TO KILL SOME 3776 02:45:07,360 --> 02:45:09,120 PROMISE JUST TO ADVANTAGE 3777 02:45:09,120 --> 02:45:11,880 BANDWIDTH BUT THIS IS AN ONGOING 3778 02:45:11,880 --> 02:45:12,200 CHALLENGE. 3779 02:45:12,200 --> 02:45:14,720 MAYBE IT'S A REALLY HARD ONE. 3780 02:45:14,720 --> 02:45:19,000 YOU KNOW, IT'S USUALLY EASIER TO 3781 02:45:19,000 --> 02:45:20,320 GET EXCITEMENT AND SUPPORT, 3782 02:45:20,320 --> 02:45:22,040 MEANING BUDGET SUPPORT IN THIS 3783 02:45:22,040 --> 02:45:25,120 CASE, FOR BRAND NEW SHINY 3784 02:45:25,120 --> 02:45:25,360 THINGS. 3785 02:45:25,360 --> 02:45:26,520 NOBODY REALLY WANTS TO FUND 3786 02:45:26,520 --> 02:45:28,040 THINGS THAT HAVE BEEN AROUND. 3787 02:45:28,040 --> 02:45:30,040 IT JUST GETS KIND OF PUSHED TO 3788 02:45:30,040 --> 02:45:31,880 THE NEXT PERSON, YOU KNOW, IN A 3789 02:45:31,880 --> 02:45:32,080 WAY. 3790 02:45:32,080 --> 02:45:34,520 AND THAT'S NOT A FAULT. 3791 02:45:34,520 --> 02:45:39,200 THAT'S JUST I GUESS MY 3792 02:45:39,200 --> 02:45:39,960 OBSERVATION. 3793 02:45:39,960 --> 02:45:42,400 AND IT'S HARD, PEOPLE GET USED 3794 02:45:42,400 --> 02:45:44,520 TO HAVING THOSE RESOURCES, IT 3795 02:45:44,520 --> 02:45:48,240 DOESN'T WORK, FOR ME, THAT'S THE 3796 02:45:48,240 --> 02:45:49,640 END OF THE WORLD. 3797 02:45:49,640 --> 02:45:52,160 THERE'S A HIGH EXPECTATION OF 3798 02:45:52,160 --> 02:45:54,560 WORKING THERE AND BEING THERE, 3799 02:45:54,560 --> 02:45:54,760 RIGHT? 3800 02:45:54,760 --> 02:45:57,600 AND SO ONE OF THE WAYS THAT 3801 02:45:57,600 --> 02:46:00,480 WE'RE THINKING ABOUT DOING THIS 3802 02:46:00,480 --> 02:46:04,080 IS BASICALLY TO BUILD USER 3803 02:46:04,080 --> 02:46:08,240 COMMUNITIES AND TO GET BROADER 3804 02:46:08,240 --> 02:46:09,680 ADOPTION OUTSIDE OF OUR 3805 02:46:09,680 --> 02:46:10,520 IMMEDIATE GROUPS. 3806 02:46:10,520 --> 02:46:14,880 THIS OF COURSE REQUIRES EFFORT, 3807 02:46:14,880 --> 02:46:18,200 BECAUSE THEN FAMILIARIZE PEOPLE, 3808 02:46:18,200 --> 02:46:20,160 ET CETERA, THIS IS HOW WE'RE 3809 02:46:20,160 --> 02:46:22,560 THINKING ABOUT IT, AND ALSO 3810 02:46:22,560 --> 02:46:24,560 ENGAGING WITH OTHERS. 3811 02:46:24,560 --> 02:46:26,080 OTHER INSTITUTIONS HAVE STRONG 3812 02:46:26,080 --> 02:46:29,480 USE CASES, THEN, YOU KNOW, WE 3813 02:46:29,480 --> 02:46:37,120 CAN GET SOME SUPPORT FROM THEM 3814 02:46:37,120 --> 02:46:37,480 AS WELL. 3815 02:46:37,480 --> 02:46:39,640 >> THANKS A LOT. 3816 02:46:39,640 --> 02:46:42,840 OBVIOUSLY IT'S A EFFICIENT WAY, 3817 02:46:42,840 --> 02:46:46,880 I PARTICULARLY LIKE THE 3818 02:46:46,880 --> 02:46:49,280 BOTTOM-UP APPROACH, YOUR TEAM 3819 02:46:49,280 --> 02:46:51,120 MEMBERS GET EXCITE AND HAVE 3820 02:46:51,120 --> 02:46:54,200 INSIGHT TO SCALE THEM UP TO 3821 02:46:54,200 --> 02:46:58,040 SOLUTIONS WHICH ARE NOT LAB. 3822 02:46:58,040 --> 02:47:00,760 IT ALSO BEHOOVES YOU TO IDENTIFY 3823 02:47:00,760 --> 02:47:05,040 WHAT ARE CRITICAL AREAS UNIQUE, 3824 02:47:05,040 --> 02:47:08,640 WHAT SETS YOU APART FROM LARGE 3825 02:47:08,640 --> 02:47:10,720 INFORMIC POOL OUTSIDE THE NCATS 3826 02:47:10,720 --> 02:47:12,720 PROGRAM AND THAT'S WHAT I WOULD 3827 02:47:12,720 --> 02:47:13,680 EXPECT TO SEE PROGRAMMATIC 3828 02:47:13,680 --> 02:47:16,120 STRATEGIC PLAN TO SAY THOSE ARE 3829 02:47:16,120 --> 02:47:18,600 AREAS WHERE ONLY WE CAN MAKE THE 3830 02:47:18,600 --> 02:47:21,120 DIFFERENCE, AND NOT, YOU KNOW, 3831 02:47:21,120 --> 02:47:23,120 THE GROUP IN HARVARD GENERATING 3832 02:47:23,120 --> 02:47:24,520 DATA, WHICH THEY PROBABLY COULD 3833 02:47:24,520 --> 02:47:26,280 HAVE BUILT THESE TOOLS AS WELL. 3834 02:47:26,280 --> 02:47:28,120 BUT WHAT MAKES YOU UNIQUE AND 3835 02:47:28,120 --> 02:47:34,800 THEREFORE ONLY YOU CAN DO THAT? 3836 02:47:34,800 --> 02:47:37,200 THOSE SHOULD BE PROJECTS TO GET 3837 02:47:37,200 --> 02:47:47,760 EXTRA PRIORITY STAR ATTACHED TO 3838 02:47:52,080 --> 02:47:52,200 THEM. 3839 02:47:52,200 --> 02:47:53,840 >> GREAT POINT. 3840 02:47:53,840 --> 02:47:54,560 THANKS, MATTIAS. 3841 02:47:54,560 --> 02:47:59,920 PAUL HARRIS, DID I SEE YOUR HAD 3842 02:47:59,920 --> 02:48:00,120 UP? 3843 02:48:00,120 --> 02:48:01,040 >>YES. 3844 02:48:01,040 --> 02:48:01,680 IMPRESSIVE PORTFOLIO, WHAT 3845 02:48:01,680 --> 02:48:03,920 YOU'VE DONE IN A SHORT AMOUNT OF 3846 02:48:03,920 --> 02:48:04,240 TIME. 3847 02:48:04,240 --> 02:48:06,560 QUICK QUESTION, GOING BACK TO 3848 02:48:06,560 --> 02:48:13,080 USE CASE WHERE YOU WERE 3849 02:48:13,080 --> 02:48:14,840 COLLABORATING WITH HARVARD, WAS 3850 02:48:14,840 --> 02:48:17,240 THAT TIED TO MPC OR A DIFFERENT 3851 02:48:17,240 --> 02:48:17,480 PROJECT? 3852 02:48:17,480 --> 02:48:18,120 >> IT WASN'T. 3853 02:48:18,120 --> 02:48:19,640 VERY INTERESTING QUESTION. 3854 02:48:19,640 --> 02:48:25,600 I WOULD LOVE, LOVE TO TIE THAT 3855 02:48:25,600 --> 02:48:27,400 DATA WITH N3C, BECAUSE ONE OF 3856 02:48:27,400 --> 02:48:29,640 THE ASPECTS, ONE OF THE 3857 02:48:29,640 --> 02:48:32,800 STRENGTHS OF N3C IS THAT THERE'S 3858 02:48:32,800 --> 02:48:35,440 A LOT OF PHENOTYPES AVAILABLE AT 3859 02:48:35,440 --> 02:48:37,840 YOUR FINGERTIPS, BECAUSE INSIDE 3860 02:48:37,840 --> 02:48:38,840 THE ENCLAVE YOU GET ACCESS TO 3861 02:48:38,840 --> 02:48:40,480 THE CODE AND OTHER PEOPLE'S 3862 02:48:40,480 --> 02:48:41,160 WORK. 3863 02:48:41,160 --> 02:48:43,560 IF YOU'RE LOOKING FOR A CERTAIN 3864 02:48:43,560 --> 02:48:46,160 PHENOTYPE YOU CAN LITERALLY GRAB 3865 02:48:46,160 --> 02:48:49,640 IT OR GRAB THE CODE AND APPLY TO 3866 02:48:49,640 --> 02:48:51,440 YOUR COHORT. 3867 02:48:51,440 --> 02:48:55,920 TO DO THAT, OUTSIDE OF N3C, IF 3868 02:48:55,920 --> 02:48:58,560 YOU THINK OF THE THOUSANDS OF 3869 02:48:58,560 --> 02:49:00,400 PHENOTYPES, IT'S NOT POSSIBLE, 3870 02:49:00,400 --> 02:49:00,760 RIGHT? 3871 02:49:00,760 --> 02:49:03,920 IT'S REALLY, REALLY HARD TO DO. 3872 02:49:03,920 --> 02:49:05,720 AND SO I'M STILL AT IT. 3873 02:49:05,720 --> 02:49:09,560 I HOPE THAT WE WILL BE ABLE TO 3874 02:49:09,560 --> 02:49:10,240 MAKE THAT LANGUAGE. 3875 02:49:10,240 --> 02:49:14,240 I THINK IT'S ONE OF THOSE THINGS 3876 02:49:14,240 --> 02:49:16,240 TECHNICALLY IT'S POSSIBLE, 3877 02:49:16,240 --> 02:49:17,440 AGREEMENT-WISE IT GETS 3878 02:49:17,440 --> 02:49:18,080 COMPLICATED. 3879 02:49:18,080 --> 02:49:19,280 THAT'S A GREAT QUESTION. 3880 02:49:19,280 --> 02:49:29,800 YEAH, I REALLY HOPE WE CAN DO 3881 02:49:33,600 --> 02:49:34,240 THAT. 3882 02:49:34,240 --> 02:49:37,040 ALL THIS WORK, THERE'S A LOT OF 3883 02:49:37,040 --> 02:49:39,200 WORK THAT'S BEEN GOING ON FOR 3884 02:49:39,200 --> 02:49:41,320 MANY, MANY YEARS PRIOR TO ME. 3885 02:49:41,320 --> 02:49:45,240 I HAD THE LUXURY OF COMING IN TO 3886 02:49:45,240 --> 02:49:46,680 SOME ALREADY GREAT WORK, AND I 3887 02:49:46,680 --> 02:49:50,200 THINK IT WAS A MATTER OF KIND OF 3888 02:49:50,200 --> 02:49:51,520 CONSOLIDATING AND THINGS OF THAT 3889 02:49:51,520 --> 02:49:52,480 SORT. 3890 02:49:52,480 --> 02:49:53,640 I WANTED TO EXPLICITLY THANK 3891 02:49:53,640 --> 02:49:55,680 YOU, BUT I WANTED TO MENTION 3892 02:49:55,680 --> 02:50:01,480 THAT. 3893 02:50:01,480 --> 02:50:01,880 IT'S A GREAT TEAM. 3894 02:50:01,880 --> 02:50:03,240 >> THANK YOU. 3895 02:50:03,240 --> 02:50:05,280 TO THAT POINT, YOU HIT THE 3896 02:50:05,280 --> 02:50:06,400 GROUND RUNNING DESPITE THE FACT 3897 02:50:06,400 --> 02:50:09,480 HAD YOU A PANDEMIC IN THE 3898 02:50:09,480 --> 02:50:11,320 BEGINNING OF YOUR TENURE YEAR 3899 02:50:11,320 --> 02:50:15,440 AND REALLY MADE SUCH HEADWAY. 3900 02:50:15,440 --> 02:50:19,200 AND ALSO JUST TO THE POINTS, 3901 02:50:19,200 --> 02:50:23,600 MANY OF THE POINTS THAT EWY 3902 02:50:23,600 --> 02:50:29,440 MENTIONED, THINKING ABOUT THE 3903 02:50:29,440 --> 02:50:30,480 DATA SCIENCE, INFORMATICS, 3904 02:50:30,480 --> 02:50:31,040 INTEROPERABILITY, EXPLICIT 3905 02:50:31,040 --> 02:50:33,240 STREAMS OF WHAT WE'RE DOING IN 3906 02:50:33,240 --> 02:50:34,640 THE STRATEGIC PLAN ALSO, AND 3907 02:50:34,640 --> 02:50:35,880 YOU'RE NOT HEARING AS MUCH ABOUT 3908 02:50:35,880 --> 02:50:37,960 THAT BECAUSE IT'S MORE OF A 3909 02:50:37,960 --> 02:50:38,280 DEEPER DIVE. 3910 02:50:38,280 --> 02:50:44,200 BUT WE ARE REALLY LOOKING INTO 3911 02:50:44,200 --> 02:50:46,520 HOW THIS IS FOUNDATIONAL TO A 3912 02:50:46,520 --> 02:50:48,600 LOT OF WORK WE'RE DOING, A PART 3913 02:50:48,600 --> 02:50:51,000 OF WEAVING THAT INTO THE FABRIC 3914 02:50:51,000 --> 02:50:52,760 OF WHAT IS NCATS AND WHAT WILL 3915 02:50:52,760 --> 02:50:53,960 MAKE UP THE STRATEGIC PLAN. 3916 02:50:53,960 --> 02:50:56,360 YOU'LL BE HEARING AND SEEING A 3917 02:50:56,360 --> 02:50:57,440 LOT OF THE FINGERPRINTS THAT 3918 02:50:57,440 --> 02:50:59,000 WERE TALKED ABOUT TODAY AS WELL 3919 02:50:59,000 --> 02:51:05,040 AS WE PROCEED IN THAT PROCESS. 3920 02:51:05,040 --> 02:51:07,960 AMIKA, YOUR HAND IS UP. 3921 02:51:07,960 --> 02:51:09,000 GO AHEAD. 3922 02:51:09,000 --> 02:51:10,480 >> QUICKLY, TO UNDERSCORE THE 3923 02:51:10,480 --> 02:51:13,880 IMPACT THIS WORK CAN HAVE WHEN 3924 02:51:13,880 --> 02:51:16,080 YOU'RE TALKING ABOUT MAINTENANCE 3925 02:51:16,080 --> 02:51:18,560 AND, YOU KNOW, ELEVATING NCATS 3926 02:51:18,560 --> 02:51:19,760 IN TERMS OF IMPACT, BECAUSE I 3927 02:51:19,760 --> 02:51:21,840 THINK WHAT YOU'VE SHOWN IS HOW 3928 02:51:21,840 --> 02:51:23,720 YOU CAN TAKE INFORMATICS AND 3929 02:51:23,720 --> 02:51:26,800 THESE DATABASES ARE MAKING IT 3930 02:51:26,800 --> 02:51:28,760 MORE USER FRIENDLY, WHICH WILL 3931 02:51:28,760 --> 02:51:30,600 CREATE MORE USERS OF THE 3932 02:51:30,600 --> 02:51:32,400 DATABASE, SO I THINK THAT, FOR 3933 02:51:32,400 --> 02:51:35,120 ONE, IS SOMETHING TO CONTINUE TO 3934 02:51:35,120 --> 02:51:37,000 PUSH, HOW TO CREATE OUTSIDE OF 3935 02:51:37,000 --> 02:51:38,080 THE INFORMATICS WORLD THAT CAN 3936 02:51:38,080 --> 02:51:39,200 NOW USE THIS. 3937 02:51:39,200 --> 02:51:40,840 AND THEN SECONDLY GOING BACK TO 3938 02:51:40,840 --> 02:51:44,520 THE POLICY PIECE BECAUSE I THINK 3939 02:51:44,520 --> 02:51:47,080 THAT N3C BE STORY THAT JONI 3940 02:51:47,080 --> 02:51:48,080 TOLD, YOU KNOW, I'M REALLY 3941 02:51:48,080 --> 02:51:50,320 INTERESTED TO SEE WHERE THAT 3942 02:51:50,320 --> 02:51:52,400 GOES BECAUSE IT SEEMS LIKE 3943 02:51:52,400 --> 02:51:55,280 THAT'S A REALLY COMPELLING PIECE 3944 02:51:55,280 --> 02:51:58,360 OF EVIDENCE THAT WILL HELP 3945 02:51:58,360 --> 02:52:02,320 POLICIES OR NEW MEMORIAL 3946 02:52:02,320 --> 02:52:03,480 PRACTICES NOW BECOME, BECAUSE OF 3947 02:52:03,480 --> 02:52:05,240 THAT WORK. 3948 02:52:05,240 --> 02:52:08,080 SO I THINK CONTINUING TO TELL 3949 02:52:08,080 --> 02:52:11,480 THE STORY, MORE USERS OUTSIDE OF 3950 02:52:11,480 --> 02:52:12,240 INFORMATICS AND POLICIES, 3951 02:52:12,240 --> 02:52:15,120 PRACTICES THAT CAN NOW BE 3952 02:52:15,120 --> 02:52:18,680 CREATED BECAUSE OF THIS WORK. 3953 02:52:18,680 --> 02:52:22,520 >> THANK YOU FOR THAT COMMENT. 3954 02:52:22,520 --> 02:52:23,960 THAT'S EXACTLY WHERE WE WANT IT 3955 02:52:23,960 --> 02:52:26,160 TO GO. 3956 02:52:26,160 --> 02:52:29,000 THAT'S GREAT. 3957 02:52:29,000 --> 02:52:30,760 WE ARE AT TIME, WE'RE GOING TO 3958 02:52:30,760 --> 02:52:32,960 MOVE TO THE NEXT PRESENTATION. 3959 02:52:32,960 --> 02:52:40,400 SO I WANT TO SAY THANK YOU TO 3960 02:52:40,400 --> 02:52:42,160 EWY MATHE AND ANTON, FOR HIS 3961 02:52:42,160 --> 02:52:45,800 WORK AND ROLE AS THE SCIENTIFIC 3962 02:52:45,800 --> 02:52:48,840 DIRECTOR IN DPI, AND REALLY 3963 02:52:48,840 --> 02:52:50,040 PROVIDING THE ABILITY FOR THE 3964 02:52:50,040 --> 02:52:52,080 SCIENTISTS WITHIN DPI TO GIVE 3965 02:52:52,080 --> 02:52:53,640 YOU A DEEPER DIVE IN TERMS OF 3966 02:52:53,640 --> 02:52:54,400 WHAT WE'RE DOING. 3967 02:52:54,400 --> 02:52:57,040 THE WORK IS VAST AND IT'S 3968 02:52:57,040 --> 02:52:58,480 HELPFUL TO GET THAT BIGGER 3969 02:52:58,480 --> 02:52:59,000 PICTURE. 3970 02:52:59,000 --> 02:53:01,320 SPEAKING OF A BIGGER PICTURE IN 3971 02:53:01,320 --> 02:53:03,040 TERMS OF RARE DISEASES, WE WILL 3972 02:53:03,040 --> 02:53:06,680 TURN IT OVER NOW TO P.J. BROOKS, 3973 02:53:06,680 --> 02:53:09,320 ACTING DIRECTOR OF DRDRI. 3974 02:53:09,320 --> 02:53:17,640 HE'S GOING TO INTRODUCE PROBABLY 3975 02:53:17,640 --> 02:53:19,960 TIIANA URV, PROGRAM DIRECTOR. 3976 02:53:19,960 --> 02:53:21,120 P.J., OVER TO YOU. 3977 02:53:21,120 --> 02:53:22,240 >> THANKS, JONI. 3978 02:53:22,240 --> 02:53:25,880 HAPPY TO PRESENT ON BEEHIVE OF 3979 02:53:25,880 --> 02:53:27,480 DRD RISKERI MANY ACTIVITIES 3980 02:53:27,480 --> 02:53:29,120 GOING ON, I WON'T BE ABLE TO 3981 02:53:29,120 --> 02:53:32,320 TALK ABOUT ALL, I'LL HIT SOME 3982 02:53:32,320 --> 02:53:32,960 HIGHLIGHTS. 3983 02:53:32,960 --> 02:53:38,360 BUT THE BIGGEST ONE IS THE RARE 3984 02:53:38,360 --> 02:53:39,120 DISEASE RESEARCH NETWORK. 3985 02:53:39,120 --> 02:53:42,040 I WANT TO GIVE TIINA A CHANCE TO 3986 02:53:42,040 --> 02:53:45,600 TALK ABOUT THAT AND FOLLOW UP 3987 02:53:45,600 --> 02:53:48,520 WITH OTHER HIGHLIGHTS. 3988 02:53:48,520 --> 02:53:54,520 3989 02:53:54,520 --> 02:53:55,240 3990 02:53:55,240 --> 02:53:59,800 >> I'M HERE TO TELL YOU ABOUT 3991 02:53:59,800 --> 02:54:08,520 THE CLINICAL RESEARCH NETWORK. 3992 02:54:08,520 --> 02:54:10,400 RDCRN WAS ESTABLISHED IN 2002, 3993 02:54:10,400 --> 02:54:14,760 PROGRAM HAS BEEN AROUND FOR SOME 3994 02:54:14,760 --> 02:54:15,360 TIME. 3995 02:54:15,360 --> 02:54:17,720 NIH WAS DIRECTED TO ESTABLISHING 3996 02:54:17,720 --> 02:54:19,920 REGIONAL CENTERS OF EXCELLENCE, 3997 02:54:19,920 --> 02:54:24,520 FIRST FUNDED IN 2003, HAVE GONE 3998 02:54:24,520 --> 02:54:25,640 CONSISTENTLY THROUGH COMPETITION 3999 02:54:25,640 --> 02:54:26,600 EVERY FIVE YEARS. 4000 02:54:26,600 --> 02:54:28,320 NEXT SLIDE. 4001 02:54:28,320 --> 02:54:31,080 THE CURRENT RDCRN IN A NETWORK 4002 02:54:31,080 --> 02:54:35,680 OF 20 CONSORTIA OR A NETWORK OF 4003 02:54:35,680 --> 02:54:37,440 NETWORKS, BUT THE DATA 4004 02:54:37,440 --> 02:54:41,600 MANAGEMENT AND COORDINATED 4005 02:54:41,600 --> 02:54:42,520 CENTERS. 4006 02:54:42,520 --> 02:54:44,360 NCATS PARTNERED WITH TEN 4007 02:54:44,360 --> 02:54:45,360 INSTITUTIONS AND CENTERS FOR THE 4008 02:54:45,360 --> 02:54:46,560 PROGRAM LISTED HERE. 4009 02:54:46,560 --> 02:54:48,960 THE NIH MECHANISM USED TO 4010 02:54:48,960 --> 02:54:53,200 SUPPORT THE NETWORK IS U54 4011 02:54:53,200 --> 02:54:53,840 COOPERATIVE AGREEMENT, THERE'S 4012 02:54:53,840 --> 02:54:54,560 SIGNIFICANT PROGRAMMATIC 4013 02:54:54,560 --> 02:54:56,120 INVOLVEMENT FROM NIH PROGRAM 4014 02:54:56,120 --> 02:54:58,120 OFFICIALS AND THERE'S A LOT OF 4015 02:54:58,120 --> 02:55:01,200 PARTNERSHIP AND INTERACTION 4016 02:55:01,200 --> 02:55:03,080 BETWEEN PROGRAM OFFICERS AND 4017 02:55:03,080 --> 02:55:04,040 SCIENTIFIC OFFICERS AND 4018 02:55:04,040 --> 02:55:06,680 GRANTEES, AND THE PATIENT 4019 02:55:06,680 --> 02:55:11,040 ADVOCACY GROUPS WHICH ARE AN 4020 02:55:11,040 --> 02:55:11,920 IMPORTANT PART OF DISCOVERY. 4021 02:55:11,920 --> 02:55:12,680 NEXT SLIDE PLEASE. 4022 02:55:12,680 --> 02:55:14,520 SO THE FOCUS OF THE NETWORK 4023 02:55:14,520 --> 02:55:17,560 RIGHT NOW IS CLINICAL TRIAL 4024 02:55:17,560 --> 02:55:17,840 READINESS. 4025 02:55:17,840 --> 02:55:19,680 STUDIES THAT MOVE THE CLINICAL 4026 02:55:19,680 --> 02:55:20,960 GROUP CLOSER TO SUCCESSFUL 4027 02:55:20,960 --> 02:55:22,960 CLINICAL TRIALS, FOR EXAMPLE 4028 02:55:22,960 --> 02:55:26,000 NATURAL HISTORY STUDIES, OR THE 4029 02:55:26,000 --> 02:55:29,080 IDENTIFICATION OF BIOMARKERS AND 4030 02:55:29,080 --> 02:55:29,840 DEVELOPMENT OF ENDPOINTS 4031 02:55:29,840 --> 02:55:32,160 APPROPRIATE FOR CLINICAL TRIALS. 4032 02:55:32,160 --> 02:55:33,680 EACH INDIVIDUAL CONSORTIUM 4033 02:55:33,680 --> 02:55:37,560 STUDIED THREE OR MORE DISORDERS, 4034 02:55:37,560 --> 02:55:39,280 CONSISTS OF MULTIPLE SITES, AND 4035 02:55:39,280 --> 02:55:42,160 THREE TO FIVE CLINICAL STUDIES, 4036 02:55:42,160 --> 02:55:45,120 CLINICAL PROGRAM FOR STUDIES, 4037 02:55:45,120 --> 02:55:46,200 CAREER ENHANCEMENT PROGRAM THAT 4038 02:55:46,200 --> 02:55:50,400 THEY DESIGN THEMSELVES AND HAVE 4039 02:55:50,400 --> 02:55:51,800 FULLY INTEGRATED PATIENT 4040 02:55:51,800 --> 02:55:52,360 ADVOCACY. 4041 02:55:52,360 --> 02:55:54,120 DATA MANAGEMENT AND COORDINATING 4042 02:55:54,120 --> 02:55:58,080 CENTER PROVIDES SUPPORT TO BOTH 4043 02:55:58,080 --> 02:56:01,880 INDIVIDUAL CONSORTIUM AND 4044 02:56:01,880 --> 02:56:03,000 NETWORK. 4045 02:56:03,000 --> 02:56:06,840 DMC PROVIDES ADMINISTRATIVE 4046 02:56:06,840 --> 02:56:09,160 SUPPORT, OPERATIONS, GOVERNMENT 4047 02:56:09,160 --> 02:56:13,360 CLINICAL RESEARCH SUPPORT THAT 4048 02:56:13,360 --> 02:56:15,240 COORDINATES BEST PRACTICES, 4049 02:56:15,240 --> 02:56:17,120 STANDARDIZATION, DATA MANAGEMENT 4050 02:56:17,120 --> 02:56:21,920 IN COOPERATION WITH NCATS ITRB 4051 02:56:21,920 --> 02:56:25,440 BUILDS AND MAINTAINS SECURE DATA 4052 02:56:25,440 --> 02:56:26,080 INFRASTRUCTURE. 4053 02:56:26,080 --> 02:56:31,800 AND ENGAGEMENT AND DISSEMINATION 4054 02:56:31,800 --> 02:56:34,080 FOR SUPPORT, PATIENT ENGAGEMENT 4055 02:56:34,080 --> 02:56:36,920 AND BROAD OUTREACH FOR 4056 02:56:36,920 --> 02:56:37,600 DISSEMINATION. 4057 02:56:37,600 --> 02:56:37,800 NEXT. 4058 02:56:37,800 --> 02:56:40,240 THERE'S A BROAD REACH. 4059 02:56:40,240 --> 02:56:43,840 WE HAVE 358 ACTIVE CONSORTIA, 4060 02:56:43,840 --> 02:56:47,880 197 ARE AT UNIQUE LOCATIONS 4061 02:56:47,880 --> 02:56:50,280 WHICH MEANS, FOR EXAMPLE, NINE 4062 02:56:50,280 --> 02:56:51,680 CONDUCTING CARE DISEASE RESEARCH 4063 02:56:51,680 --> 02:56:55,320 AS PART OF THE RDCRN AT THAT 4064 02:56:55,320 --> 02:56:56,520 SITE AND PARTNER 4065 02:56:56,520 --> 02:56:57,400 INTERNATIONALLY. 4066 02:56:57,400 --> 02:56:59,240 WE HAVE 11 COUNTRIES HAVING 4067 02:56:59,240 --> 02:57:05,160 ACTIVE RESEARCH SITES ACROSS THE 4068 02:57:05,160 --> 02:57:05,600 NETWORK. 4069 02:57:05,600 --> 02:57:12,360 RDCRN IS CO-LOCATED WITH OUR 4070 02:57:12,360 --> 02:57:12,560 CTSAs. 4071 02:57:12,560 --> 02:57:14,640 SO, LEADERSHIP HAS THREE 4072 02:57:14,640 --> 02:57:16,640 BRANCHES. 4073 02:57:16,640 --> 02:57:20,000 P.I. LEADERSHIP TEAM. 4074 02:57:20,000 --> 02:57:21,760 THE PATIENT ADVOCACY LEADERSHIP 4075 02:57:21,760 --> 02:57:22,320 TEAM. 4076 02:57:22,320 --> 02:57:23,320 AND THE EXECUTIVE LEADERSHIP 4077 02:57:23,320 --> 02:57:33,160 TEAM WHICH IS MADE OF BOTH THE 4078 02:57:33,160 --> 02:57:37,000 CPAG AND P.I., GUIDED BY 4079 02:57:37,000 --> 02:57:45,240 REPRESENTATIVES AND PATIENT 4080 02:57:45,240 --> 02:57:48,840 ADVOCACY GROUP. 4081 02:57:48,840 --> 02:57:51,880 THIS GROUP COORDINATED WITH THE 4082 02:57:51,880 --> 02:57:55,160 NIH REPRESENTATIVE. 4083 02:57:55,160 --> 02:57:57,160 ELECTED BY PEERS, SCHEDULED 4084 02:57:57,160 --> 02:58:00,680 ROTATION, THE VETTING BODY FOR 4085 02:58:00,680 --> 02:58:01,760 ACTIVITIES WITHIN THE NETWORK 4086 02:58:01,760 --> 02:58:05,160 WITH A WIDE VARIETY OF INTEREST 4087 02:58:05,160 --> 02:58:06,480 GROUPS WITH FOCUS ON RESEARCH. 4088 02:58:06,480 --> 02:58:08,320 ONE OF THE THINGS THAT WE REALLY 4089 02:58:08,320 --> 02:58:10,520 LIKE ABOUT THE NETWORK IS THESE 4090 02:58:10,520 --> 02:58:12,040 WORKING GROUPS ARE OPEN TO 4091 02:58:12,040 --> 02:58:12,800 ANYONE. 4092 02:58:12,800 --> 02:58:14,360 IT'S NOT JUST THE PRINCIPAL 4093 02:58:14,360 --> 02:58:20,200 INVESTIGATORS ON IT OR 4094 02:58:20,200 --> 02:58:22,680 CO-P.I.s, IT'S ANYONE WHO 4095 02:58:22,680 --> 02:58:23,840 SHOWS INTEREST, BIOINFORMATICS, 4096 02:58:23,840 --> 02:58:24,080 ANYONE. 4097 02:58:24,080 --> 02:58:27,480 SO THE PROGRAM HAS BEEN AROUND 4098 02:58:27,480 --> 02:58:29,040 FOR ALMOST 20 YEARS. 4099 02:58:29,040 --> 02:58:32,120 WE LIKE TO KEEP IT FRESH AN KEEP 4100 02:58:32,120 --> 02:58:33,440 UP WITH COMPLIANCE AND LOOK AT 4101 02:58:33,440 --> 02:58:36,320 WHERE THE NEEDS ARE IN THE RARE 4102 02:58:36,320 --> 02:58:38,160 DISEASE COMMUNITY. 4103 02:58:38,160 --> 02:58:42,680 WE'RE PREPARING TO GO INTO CYCLE 4104 02:58:42,680 --> 02:58:43,840 4, RDCRN-4. 4105 02:58:43,840 --> 02:58:49,120 ONE THING WE DID WAS EVALUATE 4106 02:58:49,120 --> 02:58:52,200 PROGRAMS, DATA WAS PRIMARY 4107 02:58:52,200 --> 02:58:52,640 IMPORTANCE. 4108 02:58:52,640 --> 02:58:55,400 SHARING TOOLS AND ENVIRONMENT, 4109 02:58:55,400 --> 02:58:58,680 NOT JUST LOOKING AT TIMES, WE'RE 4110 02:58:58,680 --> 02:59:04,800 PROVIDING THE TOOLS AN RESOURCES 4111 02:59:04,800 --> 02:59:06,520 TO THE WHOLE NETWORK AT ONE 4112 02:59:06,520 --> 02:59:06,720 TIME. 4113 02:59:06,720 --> 02:59:08,840 INSTEAD OF GETTING A GRANT, 4114 02:59:08,840 --> 02:59:11,360 PAYING FOR LICENSES, FILE 4115 02:59:11,360 --> 02:59:13,560 STORAGE, MONEY GOES TO RESEARCH, 4116 02:59:13,560 --> 02:59:17,280 NCATS PICKS UP THE TAB FOR THE 4117 02:59:17,280 --> 02:59:19,040 DIFFERENT COURSES. 4118 02:59:19,040 --> 02:59:21,440 WE HAVE TWO ENVIRONMENTS. 4119 02:59:21,440 --> 02:59:23,840 FIRST IS OPERATIONAL 4120 02:59:23,840 --> 02:59:24,840 ENVIRONMENT, THE WORKING 4121 02:59:24,840 --> 02:59:27,240 ENVIRONMENT, DEVELOPED FOR THE 4122 02:59:27,240 --> 02:59:28,040 CONSORTIA RESEARCH. 4123 02:59:28,040 --> 02:59:32,000 IT'S AN INTERNAL SITE WHERE THE 4124 02:59:32,000 --> 02:59:34,080 TOOLS ARE AVAILABLE AND SHARED 4125 02:59:34,080 --> 02:59:39,320 ACROSS THE CONSORTIA. 4126 02:59:39,320 --> 02:59:43,480 TOOLS NOW INCLUDE REDCap. 4127 02:59:43,480 --> 02:59:45,160 UM BRA, JUPITER HUB, NIH 4128 02:59:45,160 --> 02:59:47,560 TOOLBOX, THERE'S A VARIETY. 4129 02:59:47,560 --> 02:59:48,960 THE NUMBER KEEPS GROWING. 4130 02:59:48,960 --> 02:59:50,600 THIS LIVES AT NCATS BUT IS 4131 02:59:50,600 --> 02:59:52,880 MANAGED BY OUR DATA MANAGEMENT 4132 02:59:52,880 --> 02:59:54,000 COORDINATING CENTER. 4133 02:59:54,000 --> 02:59:55,600 THE ENVIRONMENT WAS DEVELOPED 4134 02:59:55,600 --> 03:00:04,280 THROUGH CLOSE COLLABORATION, 4135 03:00:04,280 --> 03:00:05,080 COLLABORATIVE RELATIONSHIP, ALL 4136 03:00:05,080 --> 03:00:08,480 THE COSTS WHICH WE HOPE TO 4137 03:00:08,480 --> 03:00:09,080 CONTINUE DOING. 4138 03:00:09,080 --> 03:00:11,840 WE MANAGE THE SECURITY. 4139 03:00:11,840 --> 03:00:12,960 WE HAVE MULTI-FACTOR 4140 03:00:12,960 --> 03:00:18,960 AUTHENTICATION THROUGH DUO, SO 4141 03:00:18,960 --> 03:00:21,480 THERE'S NO ON-SITE 4142 03:00:21,480 --> 03:00:22,160 INFRASTRUCTURE. 4143 03:00:22,160 --> 03:00:23,240 THANK YOU FOR COMING. 4144 03:00:23,240 --> 03:00:29,440 AND ALL OF THIS IS RUNNING ON 4145 03:00:29,440 --> 03:00:32,320 AWS, THIRD PARTY CONTRACTS, 4146 03:00:32,320 --> 03:00:33,280 OTHERWISE HELD BY NCATS. 4147 03:00:33,280 --> 03:00:34,400 NEXT SLIDE PLEASE. 4148 03:00:34,400 --> 03:00:36,120 WE WERE THINKING IF WE BUILD IT, 4149 03:00:36,120 --> 03:00:38,320 WILL THEY COME? 4150 03:00:38,320 --> 03:00:40,880 WE DID THIS. 4151 03:00:40,880 --> 03:00:42,280 AND THEY ARE USING. 4152 03:00:42,280 --> 03:00:44,320 MUCH CAN BE ATTRIBUTED TO 4153 03:00:44,320 --> 03:00:45,440 REACHING OUT TO INVESTIGATORS 4154 03:00:45,440 --> 03:00:47,400 FINDING OUT WHAT TYPES OF TOOLS 4155 03:00:47,400 --> 03:00:48,280 THEY NEEDED AND GIVING 4156 03:00:48,280 --> 03:00:53,320 OPPORTUNITY TO TRY THEM OUT IN A 4157 03:00:53,320 --> 03:00:53,760 SANDBOX ENVIRONMENT. 4158 03:00:53,760 --> 03:00:54,600 NEXT SLIDE. 4159 03:00:54,600 --> 03:00:57,160 BENEFIT OF WORKING AT NIH YOU 4160 03:00:57,160 --> 03:01:02,000 KNOW WHAT'S COMING DOWN THE 4161 03:01:02,000 --> 03:01:02,400 PIKE. 4162 03:01:02,400 --> 03:01:05,440 WE BEGAN PREPARING FOR IT EARLY. 4163 03:01:05,440 --> 03:01:07,640 IN FACT, WHEN WE WERE DEVELOPING 4164 03:01:07,640 --> 03:01:10,400 THE RFA OF THE CYCLE WE KNEW 4165 03:01:10,400 --> 03:01:11,680 THEY HAD DONE THAT DOWN THE 4166 03:01:11,680 --> 03:01:11,920 LINE. 4167 03:01:11,920 --> 03:01:15,960 WHAT THAT MEANS FOR THE RDCRN IS 4168 03:01:15,960 --> 03:01:19,480 THAT WE HAVE A DEVELOPMENT 4169 03:01:19,480 --> 03:01:21,880 REQUIREMENT, AND THIS PORTION OF 4170 03:01:21,880 --> 03:01:25,080 THE PROGRAM IS PERSONALLY BEING 4171 03:01:25,080 --> 03:01:28,000 BUILT, TAKES CONSENSUS DATA, DEI 4172 03:01:28,000 --> 03:01:37,120 WAS IT, DMCC WILL PROVIDE 4173 03:01:37,120 --> 03:01:38,840 ASSURANCES OF DATA QUALITY. 4174 03:01:38,840 --> 03:01:43,120 ONE OF THE THINGS OUR DNC DOES 4175 03:01:43,120 --> 03:01:48,040 IS LOOK TO OTHER RARE DISEASE 4176 03:01:48,040 --> 03:01:49,840 GROUPS COLLECTING DATA. 4177 03:01:49,840 --> 03:01:54,280 AND A LOT OF DATA STANDARDS. 4178 03:01:54,280 --> 03:02:00,280 WHILE WE KNOW EVERYONE WILL 4179 03:02:00,280 --> 03:02:02,720 AGREE WITH ONE SET OF DATA 4180 03:02:02,720 --> 03:02:06,560 STANDARDS WE WANT TO REMAIN 4181 03:02:06,560 --> 03:02:07,720 INTEROPERABLE SO WHEN THEY HAVE 4182 03:02:07,720 --> 03:02:09,480 ACCESS THEY WILL BE ABLE TO 4183 03:02:09,480 --> 03:02:10,680 COMBINE THE DATA. 4184 03:02:10,680 --> 03:02:12,000 THE ENVIRONMENT, ONCE THE DATA 4185 03:02:12,000 --> 03:02:16,280 IS HANDED OFF TO THE SHARED 4186 03:02:16,280 --> 03:02:18,040 ENVIRONMENT, THIS ENVIRONMENT 4187 03:02:18,040 --> 03:02:19,480 THAT IS GOVERNED WILL BE 4188 03:02:19,480 --> 03:02:20,680 CONTROLLED AND WILL HAVE 4189 03:02:20,680 --> 03:02:23,520 CONTROLLED DATA ACCESS TO NCATS 4190 03:02:23,520 --> 03:02:23,880 DECKS. 4191 03:02:23,880 --> 03:02:27,120 IT IS THE INTENT THIS WILL BE 4192 03:02:27,120 --> 03:02:29,520 AVAILABLE FOR THE PUBLIC THROUGH 4193 03:02:29,520 --> 03:02:31,720 CONTROLLED ACCESS. 4194 03:02:31,720 --> 03:02:36,200 SO HOW ARE WE DOING, FOR QUITE 4195 03:02:36,200 --> 03:02:38,280 SOME TIME, NIH, I'D LIKE TO 4196 03:02:38,280 --> 03:02:42,320 THANK JOANNE, WHO I WORKED 4197 03:02:42,320 --> 03:02:44,400 CLOSELY TO WHO DID THESE 4198 03:02:44,400 --> 03:02:47,200 ANALYSES FOR US. 4199 03:02:47,200 --> 03:02:57,160 IDENTIFIED BY HUB, 28 4200 03:02:57,160 --> 03:02:57,880 CONSORTIUMS, THERE HAVE BEEN 4201 03:02:57,880 --> 03:03:04,560 2, 4202 03:03:04,560 --> 03:03:05,440 2700 PAPERS. 4203 03:03:05,440 --> 03:03:07,520 THE SAME DATA WAS USED TO 4204 03:03:07,520 --> 03:03:08,960 IDENTIFY ORGANIZATIONS THAT 4205 03:03:08,960 --> 03:03:11,160 PUBLISHED AT LEAST FIVE PIPES. 4206 03:03:11,160 --> 03:03:14,000 SO REACH OF THE NETWORK HAS BEEN 4207 03:03:14,000 --> 03:03:15,280 EXPANDING, NUMBER OF 4208 03:03:15,280 --> 03:03:15,840 ORGANIZATIONS INCREASE THE 4209 03:03:15,840 --> 03:03:16,960 GREATLY OVER TIME. 4210 03:03:16,960 --> 03:03:19,800 THERE'S A BIG INCREASE IN NUMBER 4211 03:03:19,800 --> 03:03:21,640 OF INTERNATIONAL COLLABORATIONS, 4212 03:03:21,640 --> 03:03:24,880 WHICH YOU CAN SEE ESPECIALLY IN 4213 03:03:24,880 --> 03:03:35,400 2020, 50% OF OUR COLLABORATORS. 4214 03:03:36,880 --> 03:03:38,120 WE LOOK AT CO-SHORESHIP. 4215 03:03:38,120 --> 03:03:45,240 WHAT YOU SEE -- CO-AUTHORSHIP. 4216 03:03:45,240 --> 03:03:47,840 DESPITE THE INCREASE IN SIZE, 4217 03:03:47,840 --> 03:03:49,640 NUMBER OF CLUSTERS IS DIFFERENT 4218 03:03:49,640 --> 03:03:53,320 GROUP, THINK OF THEM AS PERHAPS 4219 03:03:53,320 --> 03:03:54,280 DIFFERENT CONSORTIA. 4220 03:03:54,280 --> 03:04:03,240 THAT FLINT -- THAT DIDN'T CHAN. 4221 03:04:03,240 --> 03:04:07,640 MORE PEOPLE ARE JOINING, 4222 03:04:07,640 --> 03:04:08,720 OUTREACH IS GROWING. 4223 03:04:08,720 --> 03:04:11,240 LET'S LOOK AT THE IMPACT OF 4224 03:04:11,240 --> 03:04:13,560 NETWORK ON TRANSLATIONAL 4225 03:04:13,560 --> 03:04:13,800 OUTCOMES. 4226 03:04:13,800 --> 03:04:16,920 WE CAN PUT CLINICAL TRIALS INTO 4227 03:04:16,920 --> 03:04:18,560 TWO CATEGORIES, FUNDED BY U54 4228 03:04:18,560 --> 03:04:22,840 AND THOSE NOT FUNDED DIRECTLY, 4229 03:04:22,840 --> 03:04:25,360 BUT LEVERAGE RDCRN RESOURCES. 4230 03:04:25,360 --> 03:04:27,440 THE DIRECTLY FUNDED TRIALS ARE 4231 03:04:27,440 --> 03:04:30,400 SMALL PHASE 1 AND PHASE 2 4232 03:04:30,400 --> 03:04:32,560 CLINICAL TRIALS, 8 CLINICAL 4233 03:04:32,560 --> 03:04:35,520 TRIALS IN TOTAL SINCE 2003 4234 03:04:35,520 --> 03:04:40,200 CURRENTLY WITH 18 ONGOING 4235 03:04:40,200 --> 03:04:40,440 TRIALS. 4236 03:04:40,440 --> 03:04:44,240 22 OF THE 33 CONDUCTED AT LEAST 4237 03:04:44,240 --> 03:04:46,760 ONE CLINICAL TRIAL. 4238 03:04:46,760 --> 03:04:50,960 YOU'LL SEE THE RDCRN ASSOCIATED 4239 03:04:50,960 --> 03:04:53,560 TRIALS HAS BEEN PHASE 2, PHASE 4240 03:04:53,560 --> 03:04:55,840 3, AND AT LEAST 13 ONGOING 4241 03:04:55,840 --> 03:04:58,400 CLINICAL TRIALS THAT FALL INTO 4242 03:04:58,400 --> 03:05:01,440 THE CATEGORY AT THIS TIME. 4243 03:05:01,440 --> 03:05:02,760 THAT FUNDING COMES FROM 4244 03:05:02,760 --> 03:05:06,560 INDUSTRY, WE HAVE BUILT A 4245 03:05:06,560 --> 03:05:07,320 FOUNDATION OF CLINICAL 4246 03:05:07,320 --> 03:05:08,320 RESEARCHERS, NATURAL HISTORY, WE 4247 03:05:08,320 --> 03:05:10,920 HAVE ALL KINDS OF INFORMATION 4248 03:05:10,920 --> 03:05:12,160 FOR THEM TO USE. 4249 03:05:12,160 --> 03:05:16,080 SO THE OTHER FUNDING HAS COME 4250 03:05:16,080 --> 03:05:18,280 FROM INDUSTRY, SPECIFIC GRANTS, 4251 03:05:18,280 --> 03:05:21,120 FDA AND PATIENT ADVOCACY GROUPS. 4252 03:05:21,120 --> 03:05:24,840 THEY HAVE LEVERAGED PATIENT 4253 03:05:24,840 --> 03:05:25,720 POPULATION, CLINICAL ENDPOINTS, 4254 03:05:25,720 --> 03:05:30,000 BIOMARKERS, SAFETY AND EFFICACY 4255 03:05:30,000 --> 03:05:31,960 DATA. 4256 03:05:31,960 --> 03:05:34,920 TO DATE RDCRN HAS 8 APPROVED 4257 03:05:34,920 --> 03:05:38,640 TREATMENTS FOR RARE DISEASE. 4258 03:05:38,640 --> 03:05:41,040 JONI THOUGHT THE PIPELINE AND 4259 03:05:41,040 --> 03:05:45,720 THEN WE'VE TAKEN ADVANTAGE OF 4260 03:05:45,720 --> 03:05:50,560 HOPEFULLY HAPPY WE'RE EMBRACING 4261 03:05:50,560 --> 03:05:50,760 THIS. 4262 03:05:50,760 --> 03:05:52,120 RDCRN FACES THE CHALLENGES, 4263 03:05:52,120 --> 03:05:53,840 PROGRESS IS SLOW. 4264 03:05:53,840 --> 03:05:55,160 TRIALS ARE EXPENSIVE, QUALITY OF 4265 03:05:55,160 --> 03:05:57,440 THE DATA BEING GENERATED IS NOT 4266 03:05:57,440 --> 03:06:04,240 HIGH ENOUGH TO USE FOR TRIAL. 4267 03:06:04,240 --> 03:06:06,880 WE'RE NOT JUST LOOKING AT ONE AT 4268 03:06:06,880 --> 03:06:12,640 A TIME, NOT JUST LOOKING AT THE 4269 03:06:12,640 --> 03:06:17,280 SCIENTIFIC CHALLENGE. 4270 03:06:17,280 --> 03:06:19,880 WE'RE NOT JUST LOOKING AT 4271 03:06:19,880 --> 03:06:21,720 SCIENTIFIC CHALLENGES, WE'RE 4272 03:06:21,720 --> 03:06:23,640 ALSO LOOKING AT ADMINISTRATIVE 4273 03:06:23,640 --> 03:06:25,680 AND OPERATIONAL CHALLENGES THAT 4274 03:06:25,680 --> 03:06:27,840 HIT THE NETWORK SO WE'RE COMING 4275 03:06:27,840 --> 03:06:30,480 AT PROBLEMS FROM MULTIPLE SIDES. 4276 03:06:30,480 --> 03:06:33,640 BY FOCUSING ON ISSUES SUCH AS 4277 03:06:33,640 --> 03:06:34,760 CLINICAL TRIAL READINESS, 4278 03:06:34,760 --> 03:06:45,200 DEVELOPED A SHARED NETWORK 4279 03:06:46,000 --> 03:06:55,240 ENVIRONMENT, TARGETING -- NEXT 4280 03:06:55,240 --> 03:06:55,440 SLIDE. 4281 03:06:55,440 --> 03:07:04,000 RAREDISEASESNETWORK.ORG. 4282 03:07:04,000 --> 03:07:06,080 BACK TO P.J. 4283 03:07:06,080 --> 03:07:06,840 >> THANKS, TIINA. 4284 03:07:06,840 --> 03:07:09,360 I'LL TRY TO GO THROUGH 4285 03:07:09,360 --> 03:07:09,640 HIGHLIGHTS. 4286 03:07:09,640 --> 03:07:13,960 ANOTHER PROGRAM YOU'RE FAMILIAR 4287 03:07:13,960 --> 03:07:16,800 WITH, THE INFORMATION CENTER, 4288 03:07:16,800 --> 03:07:24,760 ANOTHER CONGRESSIONALLY MANDATED 4289 03:07:24,760 --> 03:07:25,440 PROGRAM. 4290 03:07:25,440 --> 03:07:28,920 2.0, WE HAD A MAJOR OVERALL 4291 03:07:28,920 --> 03:07:37,920 BECAUSE OF SECURITY CONCERNS. 4292 03:07:37,920 --> 03:07:42,720 ERIC RUNS A PROGRAM WITH OTHERS. 4293 03:07:42,720 --> 03:07:44,160 AS WE'VE BEEN ALLUDING WE'LL BE 4294 03:07:44,160 --> 03:07:49,200 CONTINUING TO TRY TO FIND WAYS 4295 03:07:49,200 --> 03:07:50,840 TO MAKE GARD MORE OPERABLE WITH 4296 03:07:50,840 --> 03:07:52,680 MANY ACTIVITIES AROUND THE WORLD 4297 03:07:52,680 --> 03:08:02,720 WHERE THEY ARE GENERATING MUCH 4298 03:08:02,720 --> 03:08:03,760 OF THIS DATA. 4299 03:08:03,760 --> 03:08:05,160 [AUDIO DISTORTION] 4300 03:08:05,160 --> 03:08:06,720 GARD IS PRIMARILY INFORMATION 4301 03:08:06,720 --> 03:08:09,880 SOURCE WE'RE SEEING A LOT MORE 4302 03:08:09,880 --> 03:08:12,840 EFFORTS IN RARE DISEASE SPACE 4303 03:08:12,840 --> 03:08:13,600 INCLUDING WITHIN NCATS, EWY 4304 03:08:13,600 --> 03:08:15,160 TALKED ABOUT SOME. 4305 03:08:15,160 --> 03:08:17,120 WE WANT GARD TO BE A BASE FOR 4306 03:08:17,120 --> 03:08:18,520 THOSE ACTIVITIES SO WE ALL KNOW 4307 03:08:18,520 --> 03:08:25,240 WE'RE TALKING ABOUT THE SAME 4308 03:08:25,240 --> 03:08:28,480 DISEASES, AND THE ONE AT THE TOP 4309 03:08:28,480 --> 03:08:30,480 IS SPEARHEADING THE EFFORTS WITH 4310 03:08:30,480 --> 03:08:34,200 OTHERS TO MAKE THESE ACTIVITIES 4311 03:08:34,200 --> 03:08:35,680 THE GOAL AND YOU'LL HEAR A LOT 4312 03:08:35,680 --> 03:08:38,680 MORE ABOUT THAT IN THE FUTURE. 4313 03:08:38,680 --> 03:08:41,520 ANOTHER THINK THAT'S A 4314 03:08:41,520 --> 03:08:42,040 CONTINUING AIR, DIAGNOSTIC 4315 03:08:42,040 --> 03:08:44,240 ODYSSEY, IN THE RARE DISEASE 4316 03:08:44,240 --> 03:08:44,880 SPACE. 4317 03:08:44,880 --> 03:08:52,360 I WANTED TO HIGHLIGHT THE WORK 4318 03:08:52,360 --> 03:08:52,800 HERE. 4319 03:08:52,800 --> 03:08:55,840 [AUDIO DISTORTION] 4320 03:08:55,840 --> 03:08:57,480 WE GOT THREE MULTI-DISCIPLINARY 4321 03:08:57,480 --> 03:08:59,440 GENOMIC ANALYSIS AND CLINICAL 4322 03:08:59,440 --> 03:09:00,840 APPROACHES, RARE DISEASE 4323 03:09:00,840 --> 03:09:01,880 DIAGNOSTIC ODYSSEY, AND 4324 03:09:01,880 --> 03:09:03,720 FOLLOWING UP ON SOME 4325 03:09:03,720 --> 03:09:04,800 CONVERSATIONS EARLIER REALLY 4326 03:09:04,800 --> 03:09:07,000 WANTED TO HIGHLIGHT THE ONE DOWN 4327 03:09:07,000 --> 03:09:09,640 BELOW, TRYING TO WE'VE OUT TO 4328 03:09:09,640 --> 03:09:12,680 ALL PATIENTS INCLUDING THOSE, 4329 03:09:12,680 --> 03:09:13,400 MEDICALLY UNDERSERVED 4330 03:09:13,400 --> 03:09:18,720 POPULATIONS, THAT IS ON THE NEXT 4331 03:09:18,720 --> 03:09:19,240 COHORT. 4332 03:09:19,240 --> 03:09:22,200 SO THE BIG CHALLENGE WE HAVE, 4333 03:09:22,200 --> 03:09:24,960 YOU'VE SEEN THIS SLIDE, EVER 4334 03:09:24,960 --> 03:09:30,440 INCREASING NUMBER OF DISEASES. 4335 03:09:30,440 --> 03:09:33,400 THIS IS AN IDEA -- 4336 03:09:33,400 --> 03:09:34,480 [AUDIO DISTORTION] 4337 03:09:34,480 --> 03:09:36,760 INCREASING ALL THE TIME BUT 4338 03:09:36,760 --> 03:09:38,400 NUMBER OF APPROVED THERAPIES 4339 03:09:38,400 --> 03:09:40,920 LAGGING FAR BEHIND, BACK TO THE 4340 03:09:40,920 --> 03:09:42,680 CHRIS AUSTIN QUOTE, AT THIS RATE 4341 03:09:42,680 --> 03:09:45,200 IT'S GOING TO TAKE 2,000 YEARS. 4342 03:09:45,200 --> 03:09:47,160 VERY DIFFERENT APPROACH TO 4343 03:09:47,160 --> 03:09:49,240 TACKLE ALL THESE DISEASES, 4344 03:09:49,240 --> 03:09:50,680 PARTICULARLY BECAUSE WE KNOW 4345 03:09:50,680 --> 03:09:57,040 MOLECULAR BASIS, WE OUGHT TO BE 4346 03:09:57,040 --> 03:09:59,040 ABLE TO DO SOMETHING. 4347 03:09:59,040 --> 03:10:00,240 I THINK WE CAN. 4348 03:10:00,240 --> 03:10:03,280 I THINK THE WAIT TO DO THAT IS 4349 03:10:03,280 --> 03:10:07,080 MANY DISEASES AT A TIME 4350 03:10:07,080 --> 03:10:09,840 APPROACHES, FOCUSED ON SHARED 4351 03:10:09,840 --> 03:10:14,080 MOLECULAR ETIOLOGY, AND 4352 03:10:14,080 --> 03:10:16,080 DEVELOPING THERAPEUTIC PROGRAMS, 4353 03:10:16,080 --> 03:10:17,520 PLATFORMS BROADLY APPLICABLE TO 4354 03:10:17,520 --> 03:10:18,080 MONOGENIC DISEASES. 4355 03:10:18,080 --> 03:10:20,160 ONE OF THE WAYS WE'RE TRYING TO 4356 03:10:20,160 --> 03:10:26,040 DO THIS IS TAKE A PAGE FROM THE 4357 03:10:26,040 --> 03:10:27,480 ONCOLOGY SPACE WITH STATE OF THE 4358 03:10:27,480 --> 03:10:30,640 ART TRIAL IS DRUGS THAT TARGET 4359 03:10:30,640 --> 03:10:34,680 MOLECULAR ABNORMALITIES IN 4360 03:10:34,680 --> 03:10:38,080 DIFFERENT CANSERS IS, THEY WANT 4361 03:10:38,080 --> 03:10:43,520 A DRUG THAT HITS ACROSS PATHWAYS 4362 03:10:43,520 --> 03:10:46,080 AND WE'RE TRYING TO ADOPT TO THE 4363 03:10:46,080 --> 03:10:46,520 SPACE. 4364 03:10:46,520 --> 03:10:47,600 WE'VE GOT TWO PROJECTS. 4365 03:10:47,600 --> 03:10:49,280 I'D LIKE TO DRAW YOUR ATTENTION 4366 03:10:49,280 --> 03:10:59,680 TO THE LOWER ONE THERE. 4367 03:11:03,640 --> 03:11:05,440 IN A SENSE CREATING A NEW 4368 03:11:05,440 --> 03:11:06,960 PRIMARY DISEASE BASED ON 4369 03:11:06,960 --> 03:11:10,000 MOLECULAR TARGET FOR A DRUG. 4370 03:11:10,000 --> 03:11:11,560 THAT'S A LOT MORE EFFICIENT WAY 4371 03:11:11,560 --> 03:11:13,520 TO DEVELOP, IF YOU START WITH A 4372 03:11:13,520 --> 03:11:15,160 DRUG, FIND ALL THE PATIENTS THAT 4373 03:11:15,160 --> 03:11:17,120 MIGHT RESPOND AND PUT THEM ON A 4374 03:11:17,120 --> 03:11:17,560 CLINICAL TRIAL. 4375 03:11:17,560 --> 03:11:21,080 ONE OF THE THINGS WE'RE DOING IN 4376 03:11:21,080 --> 03:11:23,080 PARTICULAR WE'VE ASKED FOR WHERE 4377 03:11:23,080 --> 03:11:24,920 THERE'S DIFFERENT KINDS OF 4378 03:11:24,920 --> 03:11:25,880 CLINICAL OUTCOME MEASURES, ONE 4379 03:11:25,880 --> 03:11:28,160 OF THE BIG CHALLENGES IN 4380 03:11:28,160 --> 03:11:29,040 APPLYING DIFFERENT DISEASES AS 4381 03:11:29,040 --> 03:11:30,080 OPPOSED TO CANCER. 4382 03:11:30,080 --> 03:11:33,560 WE ALSO HAVE AN OPEN FUNDING 4383 03:11:33,560 --> 03:11:43,480 OPPORTUNITY, SAME THING, SMALL 4384 03:11:43,480 --> 03:11:44,480 BUSINESS SPACE. 4385 03:11:44,480 --> 03:11:46,480 WE WERE TALKING ABOUT 4386 03:11:46,480 --> 03:11:49,400 INTERACTING WITH INTERNATIONAL 4387 03:11:49,400 --> 03:11:53,920 GROUPS, ONE IS RARE DISEASE 4388 03:11:53,920 --> 03:11:55,440 RESEARCH CONSORTIUM, THAT NCATS 4389 03:11:55,440 --> 03:11:56,920 HAS BEEN INVOLVED WITH, AND 4390 03:11:56,920 --> 03:11:59,240 WITHIN THIS DEVELOPED A WORKING 4391 03:11:59,240 --> 03:12:01,960 GROUP ON SHARED MOLECULAR 4392 03:12:01,960 --> 03:12:04,720 ETIOLOGIES UNDERLYING MULTIPLE 4393 03:12:04,720 --> 03:12:09,080 RARE DISEASES, I'VE GOT TO GIVE 4394 03:12:09,080 --> 03:12:10,640 DAN TAGLE CREDIT, MANY YEARS AGO 4395 03:12:10,640 --> 03:12:13,120 WE MOVED IT FORWARD. 4396 03:12:13,120 --> 03:12:16,200 THIS WORKING GROUP FROM PEOPLE 4397 03:12:16,200 --> 03:12:19,680 ALL OVER THE WORLD, GOT TOGETHER 4398 03:12:19,680 --> 03:12:23,320 AND A MANUSCRIPT IN PRESS, KIND 4399 03:12:23,320 --> 03:12:32,080 OF GETTING GRANDER VIEW OF HOW 4400 03:12:32,080 --> 03:12:33,640 THIS APPROACH -- (INAUDIBLE). 4401 03:12:33,640 --> 03:12:35,560 THIS INCLUDES INDIVIDUALS IN 4402 03:12:35,560 --> 03:12:37,240 REGULATORY AGENCIES IN THE U.S. 4403 03:12:37,240 --> 03:12:38,560 AND FROM NCATS. 4404 03:12:38,560 --> 03:12:43,600 GOING MORE INTO GENE THERAPY AND 4405 03:12:43,600 --> 03:12:46,040 GENE EDITING, IF YOU THINK ABOUT 4406 03:12:46,040 --> 03:12:48,440 KIND OF A SIMPLIFIED VERSION OF 4407 03:12:48,440 --> 03:12:53,360 GENE THERAPY, YOU CAN THINK 4408 03:12:53,360 --> 03:12:57,320 ABOUT DELIVERY VEHICLES SUCH AS 4409 03:12:57,320 --> 03:13:00,120 ADENOASSOCIATED VIRUSES, LIKE 4410 03:13:00,120 --> 03:13:06,480 DELIVERY BOXES, WE 4411 03:13:06,480 --> 03:13:07,320 PRE-ADDRESSED. 4412 03:13:07,320 --> 03:13:10,120 STRAIGHT FORWARD TO CHANGE THE 4413 03:13:10,120 --> 03:13:13,720 CARGO AND DEVELOP TREATMENTS FOR 4414 03:13:13,720 --> 03:13:15,960 DIFFERENT MONOGENIC DISEASES BY 4415 03:13:15,960 --> 03:13:17,440 SWAPPING OUT. 4416 03:13:17,440 --> 03:13:18,960 ALSO IMAGINE IF YOU COULD DO 4417 03:13:18,960 --> 03:13:25,080 THAT COULD MAKE THE WHOLE 4418 03:13:25,080 --> 03:13:27,280 PROCESS WORK EFFICIENTLY. 4419 03:13:27,280 --> 03:13:31,320 THAT'S THE IDEA BEHIND PLATFORM 4420 03:13:31,320 --> 03:13:34,720 VECTOR PROGRAM, TRY TO TEST THE 4421 03:13:34,720 --> 03:13:39,320 HYPOTHESIS THE PLATFORM VECTOR 4422 03:13:39,320 --> 03:13:42,480 APPROACH WILL INCREASE 4423 03:13:42,480 --> 03:13:43,000 EFFICIENCY. 4424 03:13:43,000 --> 03:13:45,120 SO MOVING FORWARD WITH GENE 4425 03:13:45,120 --> 03:13:46,480 THERAPY, VERY RARE DISEASES ALL 4426 03:13:46,480 --> 03:13:53,440 UNDER STUDY AT THE NIH CLINICAL 4427 03:13:53,440 --> 03:13:54,280 CENTER, TWO MYASTHENIA 4428 03:13:54,280 --> 03:13:56,480 SYNDROMES, THE IDEA WAS TO USE 4429 03:13:56,480 --> 03:13:58,120 THE SAME SEROTYPE FOR ALL FOUR 4430 03:13:58,120 --> 03:14:01,960 AND AS WE MOVED THROUGH THE 4431 03:14:01,960 --> 03:14:03,720 PROCESS, INTERACT WITH CSA, 4432 03:14:03,720 --> 03:14:05,480 WE'LL SUGGEST DIFFERENT WAYS TO 4433 03:14:05,480 --> 03:14:08,920 STREAMLINE THE PROCESS. 4434 03:14:08,920 --> 03:14:15,320 MAYBE LESS OR NOT -- MAYBE LESS 4435 03:14:15,320 --> 03:14:15,600 TOXICOLOGY. 4436 03:14:15,600 --> 03:14:19,160 WE'LL RESPOND AND THEN WE'LL 4437 03:14:19,160 --> 03:14:20,600 MAKE THE INFORMATION PUBLIC, 4438 03:14:20,600 --> 03:14:21,800 PROFIT ENTITIES WOULD NEVER DO, 4439 03:14:21,800 --> 03:14:23,520 THEY ARE GIVING AWAY 4440 03:14:23,520 --> 03:14:24,960 INTELLECTUAL PROPERTIES, BUT 4441 03:14:24,960 --> 03:14:28,720 THAT'S OUR GOAL TO DEMOCRATIZE, 4442 03:14:28,720 --> 03:14:30,240 MAKE IT PUBLICLY AVAILABLE. 4443 03:14:30,240 --> 03:14:35,480 HIGHLIGHTING ONE OF THE FIRST 4444 03:14:35,480 --> 03:14:41,520 SUCCESSES, ON THE ORPHAN PRODUCT 4445 03:14:41,520 --> 03:14:42,600 DESIGNATION, ON THE PROGRAMMING. 4446 03:14:42,600 --> 03:14:49,040 (INAUDIBLE) 4447 03:14:49,040 --> 03:14:49,760 INTERACT MEETING. 4448 03:14:49,760 --> 03:14:52,200 WE'RE IN THE PROCESS OF MAKING 4449 03:14:52,200 --> 03:14:57,160 THOSE DOCUMENTS PUBLIC AS WELL. 4450 03:14:57,160 --> 03:14:59,560 FIRST PRE-IND MEETING, 4451 03:14:59,560 --> 03:15:04,880 ANTICIPATED IN MID-JULY AND WE 4452 03:15:04,880 --> 03:15:08,080 WILL REPEAT FOR OTHER DISEASES, 4453 03:15:08,080 --> 03:15:10,920 TO BE MORE EFFICIENT AND 4454 03:15:10,920 --> 03:15:11,240 STREAMLINED. 4455 03:15:11,240 --> 03:15:16,200 I WANT TO HIGHLIGHT THIS IS A 4456 03:15:16,200 --> 03:15:18,040 TEAM EFFORT, THERAPEUTICS 4457 03:15:18,040 --> 03:15:25,160 DEVELOPMENTS BRANCH, OFFICES ARE 4458 03:15:25,160 --> 03:15:27,360 HERE. 4459 03:15:27,360 --> 03:15:38,040 LIZ AND MANY OTHERS, CHUCK AND 4460 03:15:38,040 --> 03:15:39,400 HIS TEAM. 4461 03:15:39,400 --> 03:15:42,120 MOVING TO THE BESPOKE GENE 4462 03:15:42,120 --> 03:15:43,920 THERAPY CONSORTIUM, I WON'T GO 4463 03:15:43,920 --> 03:15:46,960 INTO DETAIL. 4464 03:15:46,960 --> 03:15:48,160 IT'S A PUBLIC/PRIVATE 4465 03:15:48,160 --> 03:15:49,720 PARTNERSHIP THAT IS ORGANIZED BY 4466 03:15:49,720 --> 03:15:51,760 THE FOUNDATION FOR THE NIH IN 4467 03:15:51,760 --> 03:15:52,880 CASE YOU'RE NOT AWARE. 4468 03:15:52,880 --> 03:15:55,600 THE FOUNDATION FOR THE NIH IS 4469 03:15:55,600 --> 03:16:02,080 NOT PART OF THE NIH. 4470 03:16:02,080 --> 03:16:04,400 IT'S A STAND-ALONE 501(C)3 4471 03:16:04,400 --> 03:16:06,240 ENTITY TO ALLOW THEM TO WORK IN 4472 03:16:06,240 --> 03:16:09,840 WAYS WE OTHERWISE COULDN'T DO. 4473 03:16:09,840 --> 03:16:18,680 HAPPY TO WORK WITH TIM MILLER, 4474 03:16:18,680 --> 03:16:20,200 PETER MARKS, ALLOWS THE WHOLE 4475 03:16:20,200 --> 03:16:26,120 EFFORT TO COME TOGETHER. 4476 03:16:26,120 --> 03:16:27,160 AND PARTNERS FROM FNIH, COURTNEY 4477 03:16:27,160 --> 03:16:27,960 AND BRAD. 4478 03:16:27,960 --> 03:16:30,800 THESE ARE ALL THE PARTNERS. 4479 03:16:30,800 --> 03:16:35,840 THIS IS THE LARGEST OF THE FNIH 4480 03:16:35,840 --> 03:16:36,960 ACCELERATED MEDICINES PROGRAMS, 4481 03:16:36,960 --> 03:16:39,440 YOU SEE 11 INSTITUTES AND 4482 03:16:39,440 --> 03:16:42,200 CENTERS, MULTIPLE FOR-PROFIT 4483 03:16:42,200 --> 03:16:43,160 ENTITIES AND NON-PROFITS, 4484 03:16:43,160 --> 03:16:45,040 INCLUDING NATIONAL ORGANIZATION 4485 03:16:45,040 --> 03:16:47,880 OF RARE DISORDERS, WE DID WANT 4486 03:16:47,880 --> 03:16:51,720 PATIENTS TO PUT INTO THIS. 4487 03:16:51,720 --> 03:16:55,520 AND 50- 50 CONTRIBUTION OF 4488 03:16:55,520 --> 03:16:58,600 PUBLIC AND PRIVATE PARTNERSHIP 4489 03:16:58,600 --> 03:16:58,960 FUNDING. 4490 03:16:58,960 --> 03:17:02,360 THERE ARE TWO MAIN COMPONENTS, 4491 03:17:02,360 --> 03:17:07,680 ONE FOCUSED ON BASIC BIOLOGY, 4492 03:17:07,680 --> 03:17:09,200 PARTICULARLY VECTOR GENERATION, 4493 03:17:09,200 --> 03:17:10,560 THERAPEUTIC GENE EXPRESSION. 4494 03:17:10,560 --> 03:17:11,960 GENE THERAPIES GOING INTO 4495 03:17:11,960 --> 03:17:12,240 PATIENTS. 4496 03:17:12,240 --> 03:17:14,640 THE BIGGEST PART OF THE PROGRAM 4497 03:17:14,640 --> 03:17:16,560 IS THE CLINICAL PART. 4498 03:17:16,560 --> 03:17:18,880 TRYING TO STREAMLINE THIS PATH 4499 03:17:18,880 --> 03:17:21,800 TO GENE THERAPY, TARGET FOR RARE 4500 03:17:21,800 --> 03:17:23,680 DISEASE AND DATA AND ANIMAL 4501 03:17:23,680 --> 03:17:25,960 MODELS INTO THE CLINIC, AND 4502 03:17:25,960 --> 03:17:28,720 DOING THINGS LIKE HARMONIZE BEST 4503 03:17:28,720 --> 03:17:28,960 PRACTICES. 4504 03:17:28,960 --> 03:17:30,480 THE NOTE AT THE BOUGHT, 4505 03:17:30,480 --> 03:17:33,160 SOMETHING WE'RE IN THE MIDDLE 4506 03:17:33,160 --> 03:17:35,880 OF, WE HAVE AN OPPORTUNITY HERE, 4507 03:17:35,880 --> 03:17:37,680 WITH INTERACTION WITH THE FDA TO 4508 03:17:37,680 --> 03:17:39,760 PROPOSE CERTAIN WAYS OF 4509 03:17:39,760 --> 03:17:41,480 STREAMLINING INCLUDING COMING UP 4510 03:17:41,480 --> 03:17:48,920 WITH A MINERAL PACKAGE OF ANIMAL 4511 03:17:48,920 --> 03:17:49,520 TOXICOLOGY STUDIES 4512 03:17:49,520 --> 03:17:51,120 THEY ARE VERY EXPENSIVE AND WHAT 4513 03:17:51,120 --> 03:17:52,480 WE'RE DOING HERE IS WE'RE NOT 4514 03:17:52,480 --> 03:17:54,880 TRYING TO CUT CORNERS AND PUT AT 4515 03:17:54,880 --> 03:17:57,920 RISK PATIENT SAFETY BUT WE'RE 4516 03:17:57,920 --> 03:17:59,440 TAKING A SCIENCE-BASED APPROACH 4517 03:17:59,440 --> 03:18:00,960 TO ASK WHAT ARE TOXICOLOGY 4518 03:18:00,960 --> 03:18:02,160 STUDIES TELLING US AND WHAT DO 4519 03:18:02,160 --> 03:18:04,480 WE NEED TO KNOW TO GET THESE 4520 03:18:04,480 --> 03:18:08,640 TRIALS UP AND RUNNING QUICKLY 4521 03:18:08,640 --> 03:18:10,960 AND SAFELY. 4522 03:18:10,960 --> 03:18:17,840 WE'LL HAVE A CONVERSATION WITH 4523 03:18:17,840 --> 03:18:28,200 FDA AS MOVE FORWARD. 4524 03:18:28,720 --> 03:18:30,720 WE NEED TO DO BETTER GENE 4525 03:18:30,720 --> 03:18:34,080 THERAPY TRIALS, LIKE THE AGT. 4526 03:18:34,080 --> 03:18:38,080 AND WE HAD AN OPEN NOMINATION 4527 03:18:38,080 --> 03:18:40,360 PROCESS, WE GOT 62 APPLICATIONS. 4528 03:18:40,360 --> 03:18:41,680 NEARLY ALL WOULD HAVE BEEN A 4529 03:18:41,680 --> 03:18:43,120 GOOD FIT. 4530 03:18:43,120 --> 03:18:45,080 SO INDICATION OF THE GREAT NEED 4531 03:18:45,080 --> 03:18:47,400 IN THIS SPACE. 4532 03:18:47,400 --> 03:18:49,840 THERE WAS INITIALLY CUT OUT FOR 4533 03:18:49,840 --> 03:18:55,720 14, WE SELECTED 8 TO GO FORWARD, 4534 03:18:55,720 --> 03:18:57,360 FIRST IN HUMAN TRIALS. 4535 03:18:57,360 --> 03:19:01,720 AND THIS IS THE SEVEN DISEASES 4536 03:19:01,720 --> 03:19:06,520 WE GIST ANNOUNCED LAST WEEK 4537 03:19:06,520 --> 03:19:10,040 ACTUALLY. 4538 03:19:10,040 --> 03:19:20,600 THREE OCULAR, THREE NEUROLOGIC. 4539 03:19:26,080 --> 03:19:28,240 WE'RE AT THE POINT OF SETTING UP 4540 03:19:28,240 --> 03:19:31,440 AND STARTING UP THE EIGHT 4541 03:19:31,440 --> 03:19:32,760 TRIALS, BOTH EXCITING AND 4542 03:19:32,760 --> 03:19:34,680 SOMETHING TO THINK ABOUT. 4543 03:19:34,680 --> 03:19:36,120 LOOKING FORWARD TO THIS 4544 03:19:36,120 --> 03:19:36,480 CHALLENGE. 4545 03:19:36,480 --> 03:19:39,200 FINALLY I'LL MOVE TO THE SOMATIC 4546 03:19:39,200 --> 03:19:42,080 CELL GENOME EDITING PROBLEM 4547 03:19:42,080 --> 03:19:46,520 THAT'S FUNDED BY THE COMMON 4548 03:19:46,520 --> 03:19:46,960 FUND. 4549 03:19:46,960 --> 03:19:49,160 IT WAS FOCUSED ON DEVELOPING 4550 03:19:49,160 --> 03:19:52,000 NOVEL TECHNOLOGIES AND BUILDING 4551 03:19:52,000 --> 03:19:56,200 THE FOUNDATION FOR CLINICAL 4552 03:19:56,200 --> 03:19:59,760 TRIALS, GENOME EDITING GOING 4553 03:19:59,760 --> 03:20:04,040 INTO THE CLINIC. 4554 03:20:04,040 --> 03:20:10,520 PRODUCTER SON COURT -- 4555 03:20:10,520 --> 03:20:12,320 CONSORTIUM. 4556 03:20:12,320 --> 03:20:18,360 A BIG CHUNK FROM THE WORK BY 4557 03:20:18,360 --> 03:20:21,360 DAVID LU, THE PRIME EDITOR. 4558 03:20:21,360 --> 03:20:30,000 THE COMPANY HAS SPUN OUT OF 4559 03:20:30,000 --> 03:20:33,800 WORK, AN THAT'S PHASE 1. 4560 03:20:33,800 --> 03:20:37,200 WE ALSO FUND THE TOOL KIT AT 4561 03:20:37,200 --> 03:20:38,400 UNIVERSITY OF WISCONSIN, LINKS 4562 03:20:38,400 --> 03:20:39,160 SHOWN HERE. 4563 03:20:39,160 --> 03:20:41,240 YOU CAN GO INTO THE TOOL KIT AND 4564 03:20:41,240 --> 03:20:46,320 LOOK FOR THE MODEL SYSTEMS, 4565 03:20:46,320 --> 03:20:47,280 DELIVERY SYSTEMS, ET CETERA. 4566 03:20:47,280 --> 03:20:52,400 PART OF THE PROGRAM WE FUNDED 20 4567 03:20:52,400 --> 03:21:00,480 BOARDS ON WAYS TO DELIVER GENOME 4568 03:21:00,480 --> 03:21:00,840 EDITING. 4569 03:21:00,840 --> 03:21:05,240 WE'VE ENCOURAGED PEOPLE TO DO 4570 03:21:05,240 --> 03:21:06,640 EVEN EXPERIMENTS THAT DIDN'T 4571 03:21:06,640 --> 03:21:06,840 WORK. 4572 03:21:06,840 --> 03:21:08,520 I WANT TO ENCOURAGE PEOPLE TO 4573 03:21:08,520 --> 03:21:19,040 PUT THIS DATA INTO THE PUBLIC 4574 03:21:20,320 --> 03:21:21,240 DOMAIN IN A WAY. 4575 03:21:21,240 --> 03:21:24,960 SOMETHING ELSE NOVEL WE PUT A 4576 03:21:24,960 --> 03:21:25,520 REQUIREMENT FOR INDEPENDENT 4577 03:21:25,520 --> 03:21:28,440 VALIDATION OF THE NEW DELIVERY 4578 03:21:28,440 --> 03:21:28,760 TECHNOLOGY. 4579 03:21:28,760 --> 03:21:31,200 THESE ARE THE TWO PHASE AWARDS 4580 03:21:31,200 --> 03:21:32,920 AND THE KEY POINT WAS TO GO FROM 4581 03:21:32,920 --> 03:21:36,640 THE FIRST FACE OF THE WORK IN 4582 03:21:36,640 --> 03:21:38,960 THE INVESTIGATOR'S LAB TO 4583 03:21:38,960 --> 03:21:41,680 SCALEUP PHASE REQUIRING 4584 03:21:41,680 --> 03:21:42,440 INDEPENDENT VALIDATION AND 4585 03:21:42,440 --> 03:21:44,640 FUNDING TO DO THAT. 4586 03:21:44,640 --> 03:21:48,880 HERE'S ONE EXAMPLE HOW THAT 4587 03:21:48,880 --> 03:21:49,280 WORKED. 4588 03:21:49,280 --> 03:21:55,440 AT THE TOP WORKED WITH THE 4589 03:21:55,440 --> 03:21:57,560 INVESTIGATOR'S LAB, AND THOSE 4590 03:21:57,560 --> 03:22:01,680 ARE THE CELLS, ON THE RIGHT WITH 4591 03:22:01,680 --> 03:22:06,520 TOMATO, 20% OF CELLS ARE EDITED 4592 03:22:06,520 --> 03:22:07,520 IN THE INVESTIGATOR'S LAB. 4593 03:22:07,520 --> 03:22:10,920 THAT WAS MADE BY THE SAME SYSTEM 4594 03:22:10,920 --> 03:22:13,680 BAYLOR COLLEGE OF MEDICINE 4595 03:22:13,680 --> 03:22:14,760 ACKNOWLEDGING QUITE CLOSE. 4596 03:22:14,760 --> 03:22:16,040 THIS WORK WAS PUBLISHED. 4597 03:22:16,040 --> 03:22:18,320 YOU CAN SEE THE PUBLICATION 4598 03:22:18,320 --> 03:22:19,240 INCLUDES ORIGINAL INVESTIGATORS 4599 03:22:19,240 --> 03:22:23,360 AS WELL AS THE FOLKS FROM THE 4600 03:22:23,360 --> 03:22:25,120 VALIDATION CENTER AND TWO CLOSED 4601 03:22:25,120 --> 03:22:29,600 SETS OF DATA, WHICH I THINK IS A 4602 03:22:29,600 --> 03:22:33,000 POWERFUL WAY TO -- 4603 03:22:33,000 --> 03:22:36,280 NOW MOVING TO PHASE 2, AND 4604 03:22:36,280 --> 03:22:40,200 MOVING TOWARDS THE CLINIC. 4605 03:22:40,200 --> 03:22:42,000 WE HAVE SEVERAL INITIATIVES 4606 03:22:42,000 --> 03:22:47,240 HERE, ONE ON TRYING TO DEVELOP 4607 03:22:47,240 --> 03:22:50,120 ASSAYS WITH A LEVEL OF RIGOR AND 4608 03:22:50,120 --> 03:22:51,400 REPRODUCIBILITY, BECOMING PART 4609 03:22:51,400 --> 03:22:52,680 OF THE REGULATORY PROCESS. 4610 03:22:52,680 --> 03:22:54,360 YOU CAN'T CONTROL THAT OBVIOUSLY 4611 03:22:54,360 --> 03:22:59,240 BUT WE HAVE WORKED WITH THE FDA 4612 03:22:59,240 --> 03:23:03,840 TO GET UNDERSTANDING FROM THEM. 4613 03:23:03,840 --> 03:23:05,800 WE'LL HAVE A LARGE GROUP TO 4614 03:23:05,800 --> 03:23:09,560 STUDY FOCUSED ON GETTING TO AN 4615 03:23:09,560 --> 03:23:12,040 IND FOR GENOME EDITING, 4616 03:23:12,040 --> 03:23:13,800 DIFFERENT DISEASE STATES WITH 4617 03:23:13,800 --> 03:23:19,240 THE IDEA THEY COULD BE PICKED UP 4618 03:23:19,240 --> 03:23:21,760 BY INDUSTRY, SIMILAR TO THE 4619 03:23:21,760 --> 03:23:29,280 TOOLKIT FROM PHASE 1. 4620 03:23:29,280 --> 03:23:31,760 ONE OTHER INITIATIVE, IT'S 4621 03:23:31,760 --> 03:23:34,720 FOCUSED ON SUPPORTING PLATFORM 4622 03:23:34,720 --> 03:23:38,360 CLINICAL TRIALS OF GENOME OH DID 4623 03:23:38,360 --> 03:23:41,280 ITERS, PUP DISEASES. 4624 03:23:41,280 --> 03:23:43,920 IT'S A THERAPEUTIC PRATT FORM, 4625 03:23:43,920 --> 03:23:46,200 BUT A TYPICAL WAY, YOU WANT TO 4626 03:23:46,200 --> 03:23:49,040 ENCOURAGE THE IDEA OF DEVELOPING 4627 03:23:49,040 --> 03:23:50,360 THERAPEUTIC PLATFORMS AS 4628 03:23:50,360 --> 03:23:51,880 THERAPEUTIC PLATFORMS FROM THE 4629 03:23:51,880 --> 03:23:55,440 BEGINNING, AND THAT'S WHY WE PUT 4630 03:23:55,440 --> 03:23:57,240 OUT THAT TERMINOLOGY PAPER. 4631 03:23:57,240 --> 03:23:59,120 AND I HOPE TO MAYBE TELL YOU 4632 03:23:59,120 --> 03:24:02,320 MORE AT THE NEXT COUNCIL ABOUT 4633 03:24:02,320 --> 03:24:03,840 HOW THAT WORKED OUT. 4634 03:24:03,840 --> 03:24:05,480 AND FINALLY ONE THING WE'RE 4635 03:24:05,480 --> 03:24:06,800 EXCITED ABOUT IN PHASE 2 IS TO 4636 03:24:06,800 --> 03:24:15,400 DO A LITTLE BIT MORE OR NEW 4637 03:24:15,400 --> 03:24:20,000 APPROACH TO DEVELOPING. 4638 03:24:20,000 --> 03:24:21,680 PHASE 1 WE FUNDED ONE, HERE THE 4639 03:24:21,680 --> 03:24:25,720 IDEA TO DO A PRIZE CHALLENGE. 4640 03:24:25,720 --> 03:24:29,120 WHICH WE CAN DO AT NIH, FOCUSED 4641 03:24:29,120 --> 03:24:30,120 ON TWO AREAS. 4642 03:24:30,120 --> 03:24:32,640 ONE WOULD BE PROGRAMMABLE 4643 03:24:32,640 --> 03:24:37,080 DELIVERY SYSTEMS, WHERE YOU 4644 03:24:37,080 --> 03:24:38,200 DEVELOP PROGRAM TO BUILD 4645 03:24:38,200 --> 03:24:41,600 DISTINCT CELL TYPE TISSUE AND 4646 03:24:41,600 --> 03:24:41,840 ORGANS. 4647 03:24:41,840 --> 03:24:47,080 AND THE OTHER IS LOOKING FOR 4648 03:24:47,080 --> 03:24:50,040 HIGHLY EFFICIENT NON-VIRAL 4649 03:24:50,040 --> 03:24:51,360 DELIVERY SYSTEMS ACROSS THE 4650 03:24:51,360 --> 03:24:53,120 BLOOD-BRAIN BARRIER. 4651 03:24:53,120 --> 03:24:55,640 MAJORITY OF TARGET CELL TYPES, 4652 03:24:55,640 --> 03:25:00,640 AND THIS ONE, THE WAY YOU SET IT 4653 03:25:00,640 --> 03:25:03,040 UP TOP COMPETITORS GO UP TO A 4654 03:25:03,040 --> 03:25:06,240 MILLION DOLLARS IN PRIZE MONEY. 4655 03:25:06,240 --> 03:25:10,840 AS WITH PHASE 1 WILL INCLUDE 4656 03:25:10,840 --> 03:25:11,160 VALIDATION. 4657 03:25:11,160 --> 03:25:14,000 GOT AN INFORMATIONAL WEBINAR 4658 03:25:14,000 --> 03:25:14,280 NEXT WEEK. 4659 03:25:14,280 --> 03:25:17,840 THERE'S THE CODE. 4660 03:25:17,840 --> 03:25:20,040 BY ALL MEANS, LET FOLKS KNOW. 4661 03:25:20,040 --> 03:25:22,960 WE'RE HOPING IN ADDITION TO 4662 03:25:22,960 --> 03:25:25,400 TRADITIONAL ACADEMICS TO GET 4663 03:25:25,400 --> 03:25:27,600 MORE DIVERSE SET OF APPLICANTS, 4664 03:25:27,600 --> 03:25:32,280 SO THERE'S THE PRIZE CHALLENGE. 4665 03:25:32,280 --> 03:25:37,040 FINALLY TO WRAP UP, THERE'S A 4666 03:25:37,040 --> 03:25:41,040 BIT OF A SQUARE PEG IN A ROUND 4667 03:25:41,040 --> 03:25:42,480 HOLE. 4668 03:25:42,480 --> 03:25:45,640 EVERYTHING WE DO, THE BIOMEDICAL 4669 03:25:45,640 --> 03:25:48,800 SPACE FROM DEVELOPINGMENT TO 4670 03:25:48,800 --> 03:25:56,960 REGULATORY RY PATH, YOU LEARN 4671 03:25:56,960 --> 03:25:57,400 SCREENING. 4672 03:25:57,400 --> 03:25:59,280 ALMOST ALL IS DEVELOPING 4673 03:25:59,280 --> 03:26:00,280 TREATMENT FOR INDIVIDUAL 4674 03:26:00,280 --> 03:26:01,000 DISEASES. 4675 03:26:01,000 --> 03:26:02,800 NOW WE HAVE THERAPEUTIC 4676 03:26:02,800 --> 03:26:05,320 PLATFORMS THAT ARE APPLICABLE IN 4677 03:26:05,320 --> 03:26:07,360 PRINCIPLE TO MANY DIFFERENT 4678 03:26:07,360 --> 03:26:08,680 MONOGENIC DISEASES. 4679 03:26:08,680 --> 03:26:10,240 AND THOSE TWO CONCEPTS REALLY 4680 03:26:10,240 --> 03:26:11,680 DON'T COME TOGETHER VERY WELL. 4681 03:26:11,680 --> 03:26:14,600 BUT I THINK IF WE EVER WANT TO 4682 03:26:14,600 --> 03:26:15,920 GET TREATMENT TO ALL OF THE 4683 03:26:15,920 --> 03:26:18,200 PATIENTS THAT CAN BENEFIT FROM 4684 03:26:18,200 --> 03:26:20,080 THEM, WE HAVE TO DEVELOP 4685 03:26:20,080 --> 03:26:20,800 THERAPEUTIC PLANS. 4686 03:26:20,800 --> 03:26:23,240 ABOUT A YEAR AND A HALF AGO NOW, 4687 03:26:23,240 --> 03:26:25,640 WE HAD A LARGE MEETING AT NIH. 4688 03:26:25,640 --> 03:26:27,560 ACTUALLY A SERIES OF MEETINGS, 4689 03:26:27,560 --> 03:26:32,560 THESE ARE VIRTUAL OF COURSE IN 4690 03:26:32,560 --> 03:26:33,280 2021. 4691 03:26:33,280 --> 03:26:41,840 LED BY TIINA URV, BROUGHT 4692 03:26:41,840 --> 03:26:43,040 TOGETHER PEOPLE DEVELOPING 4693 03:26:43,040 --> 03:26:45,000 TECHNOLOGIES TO MAKE PEOPLE 4694 03:26:45,000 --> 03:26:46,680 AWARE OF WHERE THIS FIELD IS 4695 03:26:46,680 --> 03:26:47,080 GOING. 4696 03:26:47,080 --> 03:26:48,480 A LOT OF THIS GOES BEYOND WHAT 4697 03:26:48,480 --> 03:26:52,920 WE CAN DO AT NIH BUT WE WANTED 4698 03:26:52,920 --> 03:26:53,960 TO CONTINUE. 4699 03:26:53,960 --> 03:26:57,360 WE HAVE PEOPLE TO THINK ABOUT 4700 03:26:57,360 --> 03:27:01,080 IT, MAYBE GOD AROUND TO 4701 03:27:01,080 --> 03:27:04,160 PUBLISHING WITH LEADERS FROM ALL 4702 03:27:04,160 --> 03:27:05,360 THESE ACTIVITIES WHICH IS 4703 03:27:05,360 --> 03:27:06,000 INTERESTING. 4704 03:27:06,000 --> 03:27:10,040 I WANT TO THANK TIINA, JOANNE, 4705 03:27:10,040 --> 03:27:16,400 MELISSA FROM NICHD FOR ALL THAT 4706 03:27:16,400 --> 03:27:16,600 WORK. 4707 03:27:16,600 --> 03:27:19,320 AND HIGHLIGHT ALL THE PEOPLE, 4708 03:27:19,320 --> 03:27:23,080 THE WONDERFUL COLLEAGUES AT 4709 03:27:23,080 --> 03:27:26,040 DRDRI, SO MANY IT'S HARD TO 4710 03:27:26,040 --> 03:27:26,280 MENTION. 4711 03:27:26,280 --> 03:27:29,400 AND I'M HAPPY TO TAKE ANY 4712 03:27:29,400 --> 03:27:38,160 QUESTIONS. 4713 03:27:38,160 --> 03:27:43,600 4714 03:27:43,600 --> 03:27:45,480 >> THANK YOU, P.J. 4715 03:27:45,480 --> 03:27:46,000 ANY QUESTIONS FOR P.J.? 4716 03:27:46,000 --> 03:27:48,520 OR TIINA? 4717 03:27:48,520 --> 03:27:49,080 >> I DON'T HAVE A QUESTION, 4718 03:27:49,080 --> 03:27:55,760 JUST THANK YOU FOR ALL THE WORK 4719 03:27:55,760 --> 03:27:56,640 YOU'RE DOING. 4720 03:27:56,640 --> 03:27:58,160 RDCRN CONTRIBUTED TO EIGHT 4721 03:27:58,160 --> 03:28:03,120 TREATMENTS FOR RARE DISEASES, A 4722 03:28:03,120 --> 03:28:04,320 SLIDE IN YOUR PROGRAM. 4723 03:28:04,320 --> 03:28:08,680 I FEEL LIKE THAT NEEDS TO BE 4724 03:28:08,680 --> 03:28:09,880 SPLASHED ON BUSES, BILLBOARDS, 4725 03:28:09,880 --> 03:28:11,840 I'M NOT JOKING. 4726 03:28:11,840 --> 03:28:17,560 THAT'S PHENOMENAL. 4727 03:28:17,560 --> 03:28:21,400 JUST THE YIELD, UNDERSCORING THE 4728 03:28:21,400 --> 03:28:22,360 POWER OF THE WORK. 4729 03:28:22,360 --> 03:28:26,240 THANK YOU FOR ALL THAT WORK. 4730 03:28:26,240 --> 03:28:28,680 >> THANK YOU FOR THAT COMMENT. 4731 03:28:28,680 --> 03:28:29,920 I COMPLETELY AGREE AND WE'RE 4732 03:28:29,920 --> 03:28:32,680 TRYING TO FIGURE OUT HOW CAN WE 4733 03:28:32,680 --> 03:28:36,920 DO MORE OF THIS WITHIN OUR 4734 03:28:36,920 --> 03:28:39,640 DCCRN, YOU KNOW, WE'RE LIMITED 4735 03:28:39,640 --> 03:28:41,200 BY OUR RESOURCES BUT I THINK 4736 03:28:41,200 --> 03:28:44,920 THAT THE PROGRAM IS BECOMING 4737 03:28:44,920 --> 03:28:46,120 MORE MATURE AND LESSONS WE'VE 4738 03:28:46,120 --> 03:28:48,200 LEARNED ALONG THE WAY HAVE BEEN 4739 03:28:48,200 --> 03:28:52,120 VALUABLE. 4740 03:28:52,120 --> 03:28:57,240 SO THAT'S THE HOPE TO PUSH THAT 4741 03:28:57,240 --> 03:29:02,200 IDEA. 4742 03:29:02,200 --> 03:29:02,840 MATTIAS, GO AHEAD. 4743 03:29:02,840 --> 03:29:06,320 >> ALSO WHAT WE'VE SEEN IN THE 4744 03:29:06,320 --> 03:29:08,640 PRESENTATION AS WELL, LESSONS 4745 03:29:08,640 --> 03:29:11,960 LEARNED IN THE FIELD BY RDCRN, 4746 03:29:11,960 --> 03:29:14,560 FORMALIZED AND SHARED WIDELY. 4747 03:29:14,560 --> 03:29:14,840 P.J. 4748 03:29:14,840 --> 03:29:16,640 I WANT TO ENCOURAGE YOU AS YOU 4749 03:29:16,640 --> 03:29:18,320 HAVE TOOL SETS OUT THERE WHERE 4750 03:29:18,320 --> 03:29:22,120 YOU TAKE THOSE AND MAKE THEM 4751 03:29:22,120 --> 03:29:23,440 ACCESSIBLE TO THE COMMUNITY AT 4752 03:29:23,440 --> 03:29:26,080 LARGE, THAT'S AN EFFORT YOU 4753 03:29:26,080 --> 03:29:27,840 CONTINUE TO WRITE IN OUR TOOLBOX 4754 03:29:27,840 --> 03:29:30,680 AND MAKE SURE YOU HAVE THE 4755 03:29:30,680 --> 03:29:31,880 SUPPORT AND IP INFRASTRUCTURE IN 4756 03:29:31,880 --> 03:29:34,840 PLACE TO DO THAT. 4757 03:29:34,840 --> 03:29:36,240 BECAUSE THEN OBVIOUSLY THE 4758 03:29:36,240 --> 03:29:39,440 SOLUTION WORKING FOR A SMALL SET 4759 03:29:39,440 --> 03:29:41,720 OF RARE DISEASES, IN A WIDE 4760 03:29:41,720 --> 03:29:45,040 SPECTRUM OF DISEASES AS WELL, 4761 03:29:45,040 --> 03:29:50,080 AND OUR PATIENT INTEREST CLOSELY 4762 03:29:50,080 --> 03:29:51,080 ALIGNED, OBVIOUSLY A KEY 4763 03:29:51,080 --> 03:29:55,560 DISTRIBUTION, DOING QUITE WELL 4764 03:29:55,560 --> 03:29:58,080 AND HOPEFULLY WITH YOUR TEAM AND 4765 03:29:58,080 --> 03:30:01,680 FACILITATE THESE EFFORTS GOING 4766 03:30:01,680 --> 03:30:01,920 FORWARD. 4767 03:30:01,920 --> 03:30:02,360 >> THANKS, MATTIAS. 4768 03:30:02,360 --> 03:30:06,640 >> I HAVE A QUESTION. 4769 03:30:06,640 --> 03:30:08,160 SO, THE OVERVIEW DISRUPTION THAT 4770 03:30:08,160 --> 03:30:11,000 YOU'RE TALKING ABOUT, AND I FEEL 4771 03:30:11,000 --> 03:30:13,640 LIKE NOBODY IS THINKING OR 4772 03:30:13,640 --> 03:30:15,800 REACTING SO IT'S CONTROVERSIAL 4773 03:30:15,800 --> 03:30:20,640 TO IMAGINE A WORLD WHERE COMMON 4774 03:30:20,640 --> 03:30:22,280 PATHWAY CAN BE AN APPROACH TO 4775 03:30:22,280 --> 03:30:23,160 REGULATORY APPROVAL. 4776 03:30:23,160 --> 03:30:24,560 WHAT NEEDS TO CHANGE IN THE REAL 4777 03:30:24,560 --> 03:30:26,400 WORLD WITH FDA TO MAKE THAT 4778 03:30:26,400 --> 03:30:27,080 HAPPEN? 4779 03:30:27,080 --> 03:30:29,600 I FEEL LIKE YOU ALLUDED, LIKE 4780 03:30:29,600 --> 03:30:33,320 YOU KNOW MORE AND I WOULD LOVE 4781 03:30:33,320 --> 03:30:34,640 TO UNDERSTAND WHAT REALLY NEEDS 4782 03:30:34,640 --> 03:30:37,040 TO HAPPEN SO WE COULD ALL APPLY 4783 03:30:37,040 --> 03:30:38,080 IN OUR PATIENT COMMUNITIES. 4784 03:30:38,080 --> 03:30:39,240 >>A COUPLE THINGS. 4785 03:30:39,240 --> 03:30:45,720 IN TERMS OF SHARED MOLECULAR 4786 03:30:45,720 --> 03:30:48,080 PHYSIOLOGY, I'M NOT SURE THE 4787 03:30:48,080 --> 03:30:53,000 REGULATORY -- THERE IS SO MUCH 4788 03:30:53,000 --> 03:30:55,120 REGULATORY CHALLENGE. 4789 03:30:55,120 --> 03:30:55,880 THESE ARE COOPERATIVE 4790 03:30:55,880 --> 03:31:01,600 AGREEMENTS, WHICH MEANS THAT I 4791 03:31:01,600 --> 03:31:06,560 GET TO BE INVOLVED. 4792 03:31:06,560 --> 03:31:12,920 (INAUDIBLE) 4793 03:31:12,920 --> 03:31:14,360 CONVERSATIONS I HAD, THAT'S MY 4794 03:31:14,360 --> 03:31:16,560 IMPRESSION. 4795 03:31:16,560 --> 03:31:20,120 IN TERMS OF BIOLOGICS, THAT'S A 4796 03:31:20,120 --> 03:31:20,880 WHOLE DIFFERENT DEAL. 4797 03:31:20,880 --> 03:31:21,160 >> RIGHT. 4798 03:31:21,160 --> 03:31:23,760 >> THAT'S JUST NOT THE WAY 4799 03:31:23,760 --> 03:31:26,160 PEOPLE ARE THINKING ABOUT THESE 4800 03:31:26,160 --> 03:31:27,600 THINGS. 4801 03:31:27,600 --> 03:31:33,600 AND I THINK IN PART, THE IMPETUS 4802 03:31:33,600 --> 03:31:35,480 ISN'T THERE, IT'S NOT THE WAY 4803 03:31:35,480 --> 03:31:38,440 PEOPLE THINK, EVEN THE WAY THEY 4804 03:31:38,440 --> 03:31:40,040 THINK ABOUT CALCULATING, SO I 4805 03:31:40,040 --> 03:31:42,040 THINK THAT'S PARTLY WHY WE FEET 4806 03:31:42,040 --> 03:31:47,080 WE NEED TO FUND THESE THINGS. 4807 03:31:47,080 --> 03:31:50,120 SO THEY FUND PEOPLE, THEY GO 4808 03:31:50,120 --> 03:31:52,440 FORWARD, HOW WELL THAT WORKS, SO 4809 03:31:52,440 --> 03:31:53,840 IT'S REALLY TO FUND SOME OF 4810 03:31:53,840 --> 03:31:59,960 THESE THINGS, INTERACT WITH THE 4811 03:31:59,960 --> 03:32:01,360 FDA AND COMMUNICATE BACK. 4812 03:32:01,360 --> 03:32:04,800 >> IF I COULD OFFER COMMENTARY, 4813 03:32:04,800 --> 03:32:07,200 IF YOU'RE TALKING ABOUT ONE DRUG 4814 03:32:07,200 --> 03:32:10,160 THAT THESE MANY, JUST AFFECTING 4815 03:32:10,160 --> 03:32:12,120 MULTIPLE APPLICATIONS THE FDA IS 4816 03:32:12,120 --> 03:32:13,000 COMFORTABLE WITH MOVING DRUGS 4817 03:32:13,000 --> 03:32:14,080 FORWARD IN THAT REGARD. 4818 03:32:14,080 --> 03:32:15,600 I DON'T THINK THERE'S ANY MAJOR 4819 03:32:15,600 --> 03:32:17,920 ISSUES OTHER THAN THE FDA MAY 4820 03:32:17,920 --> 03:32:20,440 HAVE A CONCERN THERE MY BE 4821 03:32:20,440 --> 03:32:22,280 UNIQUE ADVERSE EVENTS, IN ONE 4822 03:32:22,280 --> 03:32:23,640 INDICATION VERSUS NOT THE OTHER, 4823 03:32:23,640 --> 03:32:25,680 THAT'S THE ONLY THING YOU WOULD 4824 03:32:25,680 --> 03:32:29,080 BE CONCERNED WITH BESIDES HAVING 4825 03:32:29,080 --> 03:32:30,120 DEFINITE EFFICACY, PJ WAS 4826 03:32:30,120 --> 03:32:32,280 TALKING ABOUT FROM A 4827 03:32:32,280 --> 03:32:33,600 MANUFACTURING PLATFORM IT'S NOT 4828 03:32:33,600 --> 03:32:35,760 THAT FDA HAS AN ISSUE WITH IT. 4829 03:32:35,760 --> 03:32:38,640 IT'S JUST THEY HAVE DONE THIS, 4830 03:32:38,640 --> 03:32:42,880 TO A CERTAIN EXTENT THE FDA WITH 4831 03:32:42,880 --> 03:32:43,400 PERFECTLY COMFORTABLE. 4832 03:32:43,400 --> 03:32:45,640 HOW IS IT WE COME UP WITH A 4833 03:32:45,640 --> 03:32:48,240 BRAND-NEW FLU VACCINE EVERY 4834 03:32:48,240 --> 03:32:48,440 YEAR? 4835 03:32:48,440 --> 03:32:51,080 IT'S A UNIQUE PRODUCT CHANGED 4836 03:32:51,080 --> 03:32:54,160 EVERY YEAR BUT THE FDA FULLY 4837 03:32:54,160 --> 03:32:55,920 ACCEPTED THE MANUFACTURING 4838 03:32:55,920 --> 03:32:57,280 PROCESS FOR GENERATING THAT. 4839 03:32:57,280 --> 03:33:00,720 SO AS LONG AS YOU DEMONSTRATE 4840 03:33:00,720 --> 03:33:03,480 THAT YOU HAVE THE CORRECT ASSAYS 4841 03:33:03,480 --> 03:33:04,680 AT THE END, CHECK TO SEE THAT 4842 03:33:04,680 --> 03:33:06,560 WHAT YOU GOT OUT IS WHAT YOU 4843 03:33:06,560 --> 03:33:07,760 THOUGHT YOU WERE PUTTING THROUGH 4844 03:33:07,760 --> 03:33:09,960 THE PROCESS, THE FDA IS 4845 03:33:09,960 --> 03:33:11,280 PERFECTLY COMFORTABLE MOVING 4846 03:33:11,280 --> 03:33:11,920 FORWARD. 4847 03:33:11,920 --> 03:33:15,000 THAT'S THE IDEA IS DEMONSTRATE 4848 03:33:15,000 --> 03:33:16,120 THE MANUFACTURING PLATFORMS OF 4849 03:33:16,120 --> 03:33:18,840 THESE COMES OUT WITH THE SAME 4850 03:33:18,840 --> 03:33:20,680 RESULT OVER AND OVER AGAIN. 4851 03:33:20,680 --> 03:33:22,440 YOU'RE STILL GOING TO HAVE TO 4852 03:33:22,440 --> 03:33:24,240 DEMONSTRATE THE INDIVIDUAL 4853 03:33:24,240 --> 03:33:33,600 PRODUCT WORK IN THE PARTICULAR 4854 03:33:33,600 --> 03:33:33,840 DISEASE. 4855 03:33:33,840 --> 03:33:39,520 >> YOU START TALKING ABOUT 4856 03:33:39,520 --> 03:33:40,720 TREATING MANY DISEASES, WE 4857 03:33:40,720 --> 03:33:47,600 TALKED ABOUT A SCIENCE-BASED 4858 03:33:47,600 --> 03:33:48,360 APPROACH. 4859 03:33:48,360 --> 03:33:52,440 WE NEED A DIFFERENT REGULATORY 4860 03:33:52,440 --> 03:33:59,520 PATH. 4861 03:33:59,520 --> 03:34:00,880 WE HAVE DISCUSSIONS. 4862 03:34:00,880 --> 03:34:09,280 >> PART OF THE -- (INAUDIBLE) 4863 03:34:09,280 --> 03:34:14,400 IT'S JUST THERE'S MORE THAN JUST 4864 03:34:14,400 --> 03:34:15,280 THE FDA. 4865 03:34:15,280 --> 03:34:18,680 THERE'S A LOT OF DIFFERENT 4866 03:34:18,680 --> 03:34:21,760 COMPONENTS TO BRING THE PEOPLE 4867 03:34:21,760 --> 03:34:22,520 AROUND THE TABLE. 4868 03:34:22,520 --> 03:34:32,280 >>I THINK IT SEEMS ONE COULD 4869 03:34:32,280 --> 03:34:32,840 MAKE -- (INAUDIBLE). 4870 03:34:32,840 --> 03:34:33,880 >> TOPIC FOR FURTHER 4871 03:34:33,880 --> 03:34:34,480 DISCUSSION. 4872 03:34:34,480 --> 03:34:44,960 THE EXAMPLE YOU USED, THE JACK 4873 03:34:46,240 --> 03:34:47,920 PATHWAY EVERYTHING IS 1:1, IT'S 4874 03:34:47,920 --> 03:34:49,560 NOT ONE TO MANY. 4875 03:34:49,560 --> 03:34:52,960 ONE TO MANY THAT YOU ARE 4876 03:34:52,960 --> 03:34:56,120 PROPOSING IS JUST SOMETHING -- 4877 03:34:56,120 --> 03:34:58,000 WE HAVE TALENTED 4878 03:34:58,000 --> 03:34:59,080 RHEUMATOLOGISTS, THE BEST 4879 03:34:59,080 --> 03:34:59,960 PHARMA. 4880 03:34:59,960 --> 03:35:01,160 PHARMA DOESN'T HAVE THE 4881 03:35:01,160 --> 03:35:01,680 INCENTIVE. 4882 03:35:01,680 --> 03:35:04,640 IT'S A NEW KIND OF -- AS A 4883 03:35:04,640 --> 03:35:09,080 PATIENT, SOMEBODY WHO REPRESENTS 4884 03:35:09,080 --> 03:35:12,320 MANY PATIENTS, I -- I DON'T 4885 03:35:12,320 --> 03:35:16,280 THINK THAT -- MAYBE IT'S AN 4886 03:35:16,280 --> 03:35:19,120 AWARENESS ISSUE THAT FDA WILL -- 4887 03:35:19,120 --> 03:35:20,760 IS AMENABLE TO -- 4888 03:35:20,760 --> 03:35:22,520 >>THE EXAMPLES PJ HIGHLIGHTED 4889 03:35:22,520 --> 03:35:25,600 IS RELEVANT, THE FDA HAS DONE 4890 03:35:25,600 --> 03:35:27,120 THIS FOR AN ONCOLOGIC 4891 03:35:27,120 --> 03:35:29,840 INTERVENTION WHERE YOU DID NOT 4892 03:35:29,840 --> 03:35:31,840 COME IN WITH LIVER CANCER OR 4893 03:35:31,840 --> 03:35:33,680 LUNG CANCER OR SOMETHING. 4894 03:35:33,680 --> 03:35:36,320 YOU CAME WITH WITH ANY CANCER 4895 03:35:36,320 --> 03:35:37,280 WITH THIS MOLECULAR ETIOLOGY, 4896 03:35:37,280 --> 03:35:39,600 AND THE DRUG WAS DESIGNED TO 4897 03:35:39,600 --> 03:35:40,800 AFFECT THAT. 4898 03:35:40,800 --> 03:35:44,600 SO ALL COMEERS CAME IN AND THEN 4899 03:35:44,600 --> 03:35:47,920 THE FDA PASS APPROVED THAT 4900 03:35:47,920 --> 03:35:49,320 PRODUCT, SO THEY WORKED THROUGH 4901 03:35:49,320 --> 03:35:52,360 THE MECHANISM FOR DOING IT IN 4902 03:35:52,360 --> 03:36:00,920 ONCOLOGY, WHICH SORT OF ALWAYS 4903 03:36:00,920 --> 03:36:04,720 GETS A -- (INAUDIBLE). 4904 03:36:04,720 --> 03:36:05,720 >> WE CHALLENGED THEM TO SAY 4905 03:36:05,720 --> 03:36:11,640 LET'S SEE YOU DO IT MANY WAYS 4906 03:36:11,640 --> 03:36:13,240 AND MAKE THAT IT. 4907 03:36:13,240 --> 03:36:14,920 >> THE ONCOLOGY OUTCOME, ARE 4908 03:36:14,920 --> 03:36:18,200 THEY LIVING OR DEAD? 4909 03:36:18,200 --> 03:36:23,560 IF YOU'RE LOOKING AT RARE 4910 03:36:23,560 --> 03:36:25,040 DISEASES, UROLOGICAL DISORDERS, 4911 03:36:25,040 --> 03:36:28,960 IT'S NOT SO EASY TO TELL 4912 03:36:28,960 --> 03:36:29,520 SOMEBODY, IT'S CHALLENGING. 4913 03:36:29,520 --> 03:36:31,160 >> IT IS A SHIFT IN THINKING 4914 03:36:31,160 --> 03:36:36,840 BECAUSE I CAN TELL YOU AS A 4915 03:36:36,840 --> 03:36:40,880 PATHOLOGIST, IN EVERY TUMOR IF 4916 03:36:40,880 --> 03:36:42,440 YOU FOUND METASTASIS, IT'S 4917 03:36:42,440 --> 03:36:43,840 ALWAYS WHAT'S THE PRIMARY? 4918 03:36:43,840 --> 03:36:46,760 THAT'S THE BASIS FOR TREATMENT. 4919 03:36:46,760 --> 03:36:48,280 IT'S NOT WHAT IS THE PRIMARY NOW 4920 03:36:48,280 --> 03:36:50,600 BUT WHAT IS THE MOLECULAR 4921 03:36:50,600 --> 03:36:51,600 SIGNATURE OF THE TUMOR TYPE. 4922 03:36:51,600 --> 03:36:55,520 IT IS AN EVERY LUGES IN -- 4923 03:36:55,520 --> 03:36:59,000 EVOLUTION IN THE ZEALS PROCESS. 4924 03:36:59,000 --> 03:37:03,200 >> MANY OF THE ELEMENTS WE'VE 4925 03:37:03,200 --> 03:37:04,320 SEEN, IN YOUR STRATEGIC 4926 03:37:04,320 --> 03:37:06,720 STATEMENT, THIS IS THE ADVANTAGE 4927 03:37:06,720 --> 03:37:09,800 OF NCATS. 4928 03:37:09,800 --> 03:37:12,440 PLEASE TO CONTINUE TO PUSH THAT. 4929 03:37:12,440 --> 03:37:14,920 YES, YOU HAVE PLATFORMS IN PLACE 4930 03:37:14,920 --> 03:37:16,360 YOU USING TOOLS AND BLOCK FORMS. 4931 03:37:16,360 --> 03:37:26,080 YOU HAVE THE I.P. IN PLACE, TO 4932 03:37:26,080 --> 03:37:33,800 BRING THOSE BACK, AND WITH 4933 03:37:33,800 --> 03:37:39,680 REVERSE YOU REQUEST DO REVERSE 4934 03:37:39,680 --> 03:37:43,840 AND IDENTIFY PHENOTYPES. 4935 03:37:43,840 --> 03:37:45,640 JAK/STAT WAY, THEY, EVER ARE ARE 4936 03:37:45,640 --> 03:37:48,200 ARE ARE ARE ARE -- PATHWAY, 4937 03:37:48,200 --> 03:37:52,200 WE'RE TREATING PEOPLE WITH THE 4938 03:37:52,200 --> 03:37:55,880 EXCESSIVE RISK FOR KIDNEY 4939 03:37:55,880 --> 03:37:57,080 DISEASE USING MOLECULAR 4940 03:37:57,080 --> 03:37:58,520 FINGERPRINTING APPROACH FROM 4941 03:37:58,520 --> 03:37:59,840 COMMON DISEASE TO RARE DISEASE 4942 03:37:59,840 --> 03:38:03,680 IN ACQUIRED STATE. 4943 03:38:03,680 --> 03:38:05,640 IT'S A MINDSET WHICH GOES INTO 4944 03:38:05,640 --> 03:38:08,520 RARE DISEASE FIELD WHERE YOU 4945 03:38:08,520 --> 03:38:12,200 MADE SIGNIFICANT PROGRESS 4946 03:38:12,200 --> 03:38:13,640 TOWARDS COMMON DISEASE, RISKY 4947 03:38:13,640 --> 03:38:17,000 WAY TO LEAVE BEHIND DISEASES IN 4948 03:38:17,000 --> 03:38:18,880 MECHANISTIC TERMS, STARTING WITH 4949 03:38:18,880 --> 03:38:20,440 GENES BUT UNDERSTANDING THAT 4950 03:38:20,440 --> 03:38:24,680 GENETIC APPROACHES ARE NOT THE 4951 03:38:24,680 --> 03:38:26,880 ONLY OPPORTUNITY TO DO THAT BUT 4952 03:38:26,880 --> 03:38:29,200 MORE INTERMEDIARIES AS YOU 4953 03:38:29,200 --> 03:38:31,920 NICELY ALLUDED TO EARLIER THIS 4954 03:38:31,920 --> 03:38:33,760 AFTERNOON, KEY ELEMENT TO MAP 4955 03:38:33,760 --> 03:38:36,520 WELL TO CLOSE THE GAPS. 4956 03:38:36,520 --> 03:38:39,800 WE FOUND IT. 4957 03:38:39,800 --> 03:38:40,680 REGULATORY AGENCIES, THE 4958 03:38:40,680 --> 03:38:42,080 OUTCOMES OBVIOUSLY HAVE TO STAND 4959 03:38:42,080 --> 03:38:47,240 UP AND THOSE HAVE TO BE THE NO 4960 03:38:47,240 --> 03:38:54,800 AND MONEY SPECIFIC BUT FROM THE 4961 03:38:54,800 --> 03:38:56,040 OTHER APPROACHES -- (INAUDIBLE). 4962 03:38:56,040 --> 03:38:59,400 >>I'LL ADD -- THANKS FOR THAT, 4963 03:38:59,400 --> 03:39:00,600 MATTIAS. 4964 03:39:00,600 --> 03:39:02,560 I THINK THAT'S RIGHT. 4965 03:39:02,560 --> 03:39:06,160 THE OTHER PIECE IS THAT OUTCOMES 4966 03:39:06,160 --> 03:39:08,360 OF COURSE IS THE BIGGEST THING 4967 03:39:08,360 --> 03:39:12,080 BUT THE OTHER PIECE IS 4968 03:39:12,080 --> 03:39:14,680 DEVELOPING THE REGULATORY PATH 4969 03:39:14,680 --> 03:39:17,960 FOR THIS IDEA OF PRECEDENT 4970 03:39:17,960 --> 03:39:20,960 SETTING AND HOW TO MAKE SURE 4971 03:39:20,960 --> 03:39:22,600 THESE DELIVERY MECHANISMS WILL 4972 03:39:22,600 --> 03:39:24,440 BE WORKABLE IN DIFFERENT 4973 03:39:24,440 --> 03:39:24,960 SCENARIOS. 4974 03:39:24,960 --> 03:39:28,400 SO WHAT I THINK PJ'S PROGRAMS 4975 03:39:28,400 --> 03:39:32,240 ARE WORKING TOWARDS IS PROVIDING 4976 03:39:32,240 --> 03:39:34,280 THAT PRECEDENT-SETTING PROCESS 4977 03:39:34,280 --> 03:39:36,920 THAT WILL ENABLE THE REGULATORY 4978 03:39:36,920 --> 03:39:43,400 PATH BECOME MORE CLEAR FOR FDA 4979 03:39:43,400 --> 03:39:44,600 WORK AND BEYOND. 4980 03:39:44,600 --> 03:39:44,920 >>TOTALLY. 4981 03:39:44,920 --> 03:39:47,120 >> DEFINITELY WORKING TOWARD 4982 03:39:47,120 --> 03:39:47,920 THAT SPACE. 4983 03:39:47,920 --> 03:39:51,720 DID I SEE ONE OTHER HAND UP AS 4984 03:39:51,720 --> 03:39:52,000 WELL? 4985 03:39:52,000 --> 03:39:54,160 I MAY HAVE MADE IT COMPLETELY UP 4986 03:39:54,160 --> 03:39:57,720 BUT I THOUGHT I SAW ANOTHER 4987 03:39:57,720 --> 03:39:58,640 HAND. 4988 03:39:58,640 --> 03:40:04,200 OKAY, MAYBE NOT. 4989 03:40:04,200 --> 03:40:05,040 ANY OTHER COMMENTS? 4990 03:40:05,040 --> 03:40:08,360 >> I SEE SOME LOOKING AT TARGET 4991 03:40:08,360 --> 03:40:10,000 AND CHALLENGE. 4992 03:40:10,000 --> 03:40:10,560 >> EXCELLENT. 4993 03:40:10,560 --> 03:40:11,080 YES. 4994 03:40:11,080 --> 03:40:14,000 KEITH, DID YOU HAVE A COMMENT? 4995 03:40:14,000 --> 03:40:14,560 >> NO. 4996 03:40:14,560 --> 03:40:17,680 >> OKAY. 4997 03:40:17,680 --> 03:40:18,320 GREAT. 4998 03:40:18,320 --> 03:40:21,240 WELL, P.J. AND TIINA, THANK YOU 4999 03:40:21,240 --> 03:40:21,800 SO MUCH. 5000 03:40:21,800 --> 03:40:30,080 VERY MUCH FOR ALL OF THAT WORK. 5001 03:40:30,080 --> 03:40:32,560 5002 03:40:32,560 --> 03:40:35,840 IT'S FUNNY, WHEN YOU MAKE A LOT 5003 03:40:35,840 --> 03:40:37,920 OF NOISE IN THE ROOM IT GOES 5004 03:40:37,920 --> 03:40:38,880 SILENT ON OUR END. 5005 03:40:38,880 --> 03:40:40,960 I KNOW YOU WERE CLAPPING. 5006 03:40:40,960 --> 03:40:45,200 WE HAVE A LITTLE BIT MORE TIME. 5007 03:40:45,200 --> 03:40:46,240 I'M RECOGNIZING TOO THAT YOU 5008 03:40:46,240 --> 03:40:47,640 STARTED VERY EARLY TODAY. 5009 03:40:47,640 --> 03:40:49,920 I KNOW THAT BECAUSE OF THE TOUR. 5010 03:40:49,920 --> 03:40:58,600 SO I WANT TO GAUGE YOUR SORT OF 5011 03:40:58,600 --> 03:40:59,800 ENTHUSIASM FOR PRESSING ON. 5012 03:40:59,800 --> 03:41:00,680 RECOGNIZING IT IS NEARING THE 5013 03:41:00,680 --> 03:41:01,640 END OF THE TIME HERE. 5014 03:41:01,640 --> 03:41:03,720 I'M GOING TO ASK YOU, NUMBER 5015 03:41:03,720 --> 03:41:06,680 ONE, ARE YOU OKAY WITH A FEW 5016 03:41:06,680 --> 03:41:07,880 MORE MINUTES? 5017 03:41:07,880 --> 03:41:11,000 OR WE CAN ALSO CONTINUE SOME OF 5018 03:41:11,000 --> 03:41:12,760 THESE CONVERSATIONS CERTAINLY 5019 03:41:12,760 --> 03:41:14,280 NEXT TIME. 5020 03:41:14,280 --> 03:41:17,200 BUT IF I CAN HOLD YOU FOR 5021 03:41:17,200 --> 03:41:20,720 PERHAPS FIVE MORE MINUTES OR SO, 5022 03:41:20,720 --> 03:41:23,520 I'D LOVE TO CIRCLE BACK TO THIS 5023 03:41:23,520 --> 03:41:26,080 IDEA OF THE STRATEGIC PLANNING 5024 03:41:26,080 --> 03:41:28,040 QUESTIONS AND ENGAGING YOU JUST 5025 03:41:28,040 --> 03:41:30,160 A LITTLE BIT MORE, REALLY MORE 5026 03:41:30,160 --> 03:41:33,640 PICKING YOUR BRAIN AND YOUR 5027 03:41:33,640 --> 03:41:34,960 EXPERTISE AND EXPERIENCE AND 5028 03:41:34,960 --> 03:41:35,960 LEADERSHIP POSITIONS THAT YOU 5029 03:41:35,960 --> 03:41:37,240 HOLD. 5030 03:41:37,240 --> 03:41:40,840 WHAT IT MEANS TO YOU TO SORT OF 5031 03:41:40,840 --> 03:41:43,000 PUT TOGETHER A STRATEGIC PLAN, 5032 03:41:43,000 --> 03:41:44,040 PROGRAM, AND RECOGNIZING THE 5033 03:41:44,040 --> 03:41:47,040 INFORMATION THAT WE PRESENTED TO 5034 03:41:47,040 --> 03:41:49,600 YOU TODAY FROM MEREDITH AND 5035 03:41:49,600 --> 03:41:52,600 PENNY AND ALL OF THE INPUT THAT 5036 03:41:52,600 --> 03:41:53,560 WE RECEIVED, AS WE'RE STARTING 5037 03:41:53,560 --> 03:41:55,680 TO SORT OF BUILD THAT TOGETHER 5038 03:41:55,680 --> 03:41:58,600 AND PUT IT ALL TOGETHER, THE 5039 03:41:58,600 --> 03:41:59,720 ISSUE AROUND PRIORITIZATION TO 5040 03:41:59,720 --> 03:42:01,160 ME IS A BIG ONE. 5041 03:42:01,160 --> 03:42:04,960 AND SO I WOULD LOVE TO HEAR FROM 5042 03:42:04,960 --> 03:42:07,040 YOUR EXPERTISE AND YOUR 5043 03:42:07,040 --> 03:42:08,440 EXPERIENCE THINKING ABOUT LARGE 5044 03:42:08,440 --> 03:42:11,200 PROGRAMS AND AREAS TO MOVE 5045 03:42:11,200 --> 03:42:11,440 FORWARD. 5046 03:42:11,440 --> 03:42:13,200 THE WHAT AND HOW. 5047 03:42:13,200 --> 03:42:15,920 WHAT TO YOU IS MOST IMPORTANT 5048 03:42:15,920 --> 03:42:17,640 FOR THAT PRIORITIZATION FOR US, 5049 03:42:17,640 --> 03:42:19,880 GIVEN ALL THE VARIED INPUT THAT 5050 03:42:19,880 --> 03:42:22,280 WE HAVE AND VAST TRANSLATIONAL 5051 03:42:22,280 --> 03:42:24,880 SCIENCE SPECTRUM THAT WE 5052 03:42:24,880 --> 03:42:25,240 SUPPORT? 5053 03:42:25,240 --> 03:42:26,440 AND SECONDLY, SORT OF HOW DO WE 5054 03:42:26,440 --> 03:42:28,840 NEED TO BE THINKING ABOUT 5055 03:42:28,840 --> 03:42:30,120 PRIORITIZATION PROCESS. 5056 03:42:30,120 --> 03:42:33,120 AND I'LL JUST GIVE A SENSE OF 5057 03:42:33,120 --> 03:42:34,880 WHAT I'M THINKING ABOUT. 5058 03:42:34,880 --> 03:42:38,360 IN TERMS OF THAT PRIORITIZATION, 5059 03:42:38,360 --> 03:42:40,120 NUMBER ONE, I THINK -- THERE ARE 5060 03:42:40,120 --> 03:42:41,320 SEVEN POINTS. 5061 03:42:41,320 --> 03:42:42,600 NUMBER ONE, I'M THINKING THAT 5062 03:42:42,600 --> 03:42:45,040 SORT OF HAVING THE RELEVANCE TO 5063 03:42:45,040 --> 03:42:47,840 THE SORT OF STRATEGIC GOALS AND 5064 03:42:47,840 --> 03:42:49,440 MISSION OF NCATS IS CERTAINLY 5065 03:42:49,440 --> 03:42:50,960 FIRST AND FOREMOST. 5066 03:42:50,960 --> 03:42:53,680 AND HOW WE CAN ALIGN THE 5067 03:42:53,680 --> 03:42:57,000 DIFFERENT KINDS OF INPUT TO THE 5068 03:42:57,000 --> 03:42:58,000 MISSION AND VISION, THAT SEEMS 5069 03:42:58,000 --> 03:42:59,400 TO BE ONE AREA. 5070 03:42:59,400 --> 03:43:02,800 THE SECOND THING TO BE THINKING 5071 03:43:02,800 --> 03:43:04,120 ABOUT THE IMPACT, WHAT'S GOING 5072 03:43:04,120 --> 03:43:06,400 TO BE THE POTENTIAL IMPACT AND 5073 03:43:06,400 --> 03:43:07,960 INFLUENCE THAT WE CAN PROVIDE 5074 03:43:07,960 --> 03:43:09,240 BASED ON THE INFLUENCE THAT WE 5075 03:43:09,240 --> 03:43:11,880 RECEIVED AND PUT THAT INTO THE 5076 03:43:11,880 --> 03:43:12,200 FRAMEWORK. 5077 03:43:12,200 --> 03:43:15,600 AND THAT WILL HELP US CONTRIBUTE 5078 03:43:15,600 --> 03:43:17,000 TO OUR LONGER-TERM VISIONS. 5079 03:43:17,000 --> 03:43:18,320 THOSE MAY NOT NECESSARILY BE 5080 03:43:18,320 --> 03:43:21,640 SHORT TERM BUT HOW DO WE MAKE 5081 03:43:21,640 --> 03:43:23,960 SURE WE INFUSE THEM TO CONTINUE 5082 03:43:23,960 --> 03:43:25,960 THE LONG GAIN OF DEVELOPING THAT 5083 03:43:25,960 --> 03:43:26,960 VISION AHEAD? 5084 03:43:26,960 --> 03:43:29,040 AND THE THIRD PIECE IS THINKING 5085 03:43:29,040 --> 03:43:32,000 ABOUT OF COURSE FEASIBILITY AND 5086 03:43:32,000 --> 03:43:32,520 RESOURCES. 5087 03:43:32,520 --> 03:43:35,440 OBVIOUSLY WE WORK IN A ZERO SUM 5088 03:43:35,440 --> 03:43:37,680 GAIN SCENARIO AWAY. 5089 03:43:37,680 --> 03:43:39,000 VERY ANNUAL APPROPRIATIONS, ALL 5090 03:43:39,000 --> 03:43:42,320 OF THOSE TYPES OF THINGS. 5091 03:43:42,320 --> 03:43:43,960 BUT IT'S THOSE RESOURCES THAT 5092 03:43:43,960 --> 03:43:47,880 ARE FINANCE, THEY ARE ALSO HUMAN 5093 03:43:47,880 --> 03:43:48,640 RESOURCES AND TECHNOLOGICAL 5094 03:43:48,640 --> 03:43:51,280 RESOURCES, HOW DO WE MAKE SURE 5095 03:43:51,280 --> 03:43:53,160 THOSE ARE ALIGNED ALSO WITH 5096 03:43:53,160 --> 03:43:54,440 BEING ABLE TO SUPPORT THE 5097 03:43:54,440 --> 03:43:55,160 VISION. 5098 03:43:55,160 --> 03:43:58,600 SO THAT SEEMS TO BE ANOTHER AREA 5099 03:43:58,600 --> 03:44:02,880 THAT WE'LL NEED TO USE IN OUR 5100 03:44:02,880 --> 03:44:03,480 PRIORITIZATION, THINKING ABOUT 5101 03:44:03,480 --> 03:44:04,160 RISKS, FOR EXAMPLE, WHAT ARE 5102 03:44:04,160 --> 03:44:09,960 THINGS THAT MIGHT BE MORE RISKY 5103 03:44:09,960 --> 03:44:10,400 FOR US? 5104 03:44:10,400 --> 03:44:15,200 SOME 5105 03:44:15,200 --> 03:44:17,400 SOME OF US LIKE TO TAKE A RISK, 5106 03:44:17,400 --> 03:44:19,800 NOT A BAD THING, HOW DO WE NEED 5107 03:44:19,800 --> 03:44:21,280 TO PRIORITIZE? 5108 03:44:21,280 --> 03:44:25,720 WE ALSO -- I THINK SOMEONE MADE 5109 03:44:25,720 --> 03:44:27,240 THE COMMENT EARLIER, THINKING 5110 03:44:27,240 --> 03:44:30,240 HOW TO REACH BACK TO 5111 03:44:30,240 --> 03:44:31,640 STAKEHOLDERS AND ENGAGE THEM AS 5112 03:44:31,640 --> 03:44:32,720 WE CONTINUE TO MOVE FORWARD, 5113 03:44:32,720 --> 03:44:34,600 THIS IDEA OF THE SMALL 5114 03:44:34,600 --> 03:44:36,080 COMMUNICATIONS ALONG THE WAY 5115 03:44:36,080 --> 03:44:38,880 MIGHT BE ONE OF THE WAYS TO DO 5116 03:44:38,880 --> 03:44:39,280 THAT. 5117 03:44:39,280 --> 03:44:40,720 REALLY UNDERSTANDING HOW IT CAN 5118 03:44:40,720 --> 03:44:43,680 CONTINUE TO GET INPUT ALONG THE 5119 03:44:43,680 --> 03:44:47,800 WAY WILL BE IMPORTANT AS WELL. 5120 03:44:47,800 --> 03:44:50,480 I GUESS ALONG THOSE SAME LINES, 5121 03:44:50,480 --> 03:44:54,520 GETTING THAT INPUT, IS THE 5122 03:44:54,520 --> 03:44:56,240 ABILITY TO MEASURE OUR PROGRESS, 5123 03:44:56,240 --> 03:45:00,320 IF YOU WILL, IN OUR STRATEGIC 5124 03:45:00,320 --> 03:45:00,720 PLANNING PROCESS. 5125 03:45:00,720 --> 03:45:01,840 SO THAT MEASUREMENT AND 5126 03:45:01,840 --> 03:45:03,400 MONITORING OF OUR ACTIVITIES AND 5127 03:45:03,400 --> 03:45:05,360 HOW WE CAN COMMUNICATE THAT WELL 5128 03:45:05,360 --> 03:45:08,720 I THINK IS ALSO AN AREA THAT WE 5129 03:45:08,720 --> 03:45:09,600 WANT TO HIGHLIGHT. 5130 03:45:09,600 --> 03:45:11,560 I SAID SEVEN, I'M NOT SURE I 5131 03:45:11,560 --> 03:45:12,240 WENT TO SEVEN. 5132 03:45:12,240 --> 03:45:13,560 I MAY HAVE MISSED SOMETHING. 5133 03:45:13,560 --> 03:45:16,400 THOSE ARE THE KINDS OF KEY 5134 03:45:16,400 --> 03:45:20,120 POINTS THAT I WANTED TO THROW 5135 03:45:20,120 --> 03:45:21,440 OUT FOR MAYBE JUST ROUNDING OUT 5136 03:45:21,440 --> 03:45:23,960 THE DISCUSSION OF THE DAY AND 5137 03:45:23,960 --> 03:45:27,880 TO -- WHILE I HAVE YOU, CONTINUE 5138 03:45:27,880 --> 03:45:29,840 TO GET YOUR SAGE ADVICE MOVING 5139 03:45:29,840 --> 03:45:32,720 FORWARD AS WE START TO GO INTO 5140 03:45:32,720 --> 03:45:34,640 THE NEXT PHASE OF OUR STRATEGIC 5141 03:45:34,640 --> 03:45:37,080 PLAN PROCESS. 5142 03:45:37,080 --> 03:45:41,320 MEREDITH PENNY, ANYTHING TO ADD 5143 03:45:41,320 --> 03:45:43,520 BEFORE WE MOVE ON AND ASK FOR 5144 03:45:43,520 --> 03:45:43,800 COMMENTS? 5145 03:45:43,800 --> 03:45:46,080 >>WELL, I THINK WE COULD PUT A 5146 03:45:46,080 --> 03:45:47,680 MAILBOX INTO THE CHAT. 5147 03:45:47,680 --> 03:45:50,440 IF YOU WANT TO COGITATE AND SEND 5148 03:45:50,440 --> 03:45:52,280 IT TO US WE WILL TAKE IT. 5149 03:45:52,280 --> 03:45:55,160 THE OTHER THING I WANTED TO 5150 03:45:55,160 --> 03:45:57,440 EMPHASIZE, I THINK I SAID THIS 5151 03:45:57,440 --> 03:45:59,080 ONCE DURING THE PRESENTATION, 5152 03:45:59,080 --> 03:46:02,240 WE'RE NOT DONE YET GETTING YOUR 5153 03:46:02,240 --> 03:46:02,440 INPUT. 5154 03:46:02,440 --> 03:46:04,400 WE'LL BE PUTTING OUT THIS SUMMER 5155 03:46:04,400 --> 03:46:07,440 A REQUEST FOR INFORMATION SO 5156 03:46:07,440 --> 03:46:08,200 PEOPLE CAN PROVIDE AS MUCH 5157 03:46:08,200 --> 03:46:14,520 DETAIL AS THEY WANT ON THEIR 5158 03:46:14,520 --> 03:46:15,040 COMMENTS. 5159 03:46:15,040 --> 03:46:16,520 WE HAVEN'T DRAFTED WHAT THAT RFI 5160 03:46:16,520 --> 03:46:17,920 LOOKS LIKE YET. 5161 03:46:17,920 --> 03:46:20,920 MY EXPECTATION IS WE WILL TRY TO 5162 03:46:20,920 --> 03:46:22,440 SUMMARIZE WHAT WE'VE HEARD TO 5163 03:46:22,440 --> 03:46:24,760 DATE BECAUSE I DON'T THINK WE 5164 03:46:24,760 --> 03:46:26,360 NEED TO GO BROADER. 5165 03:46:26,360 --> 03:46:29,240 EVERYTHING IS WE NEED TO GO 5166 03:46:29,240 --> 03:46:30,760 DEEPER TO REALLY UNDERSTAND AND 5167 03:46:30,760 --> 03:46:33,200 GET AT WHAT ARE THE SCIENTIFIC 5168 03:46:33,200 --> 03:46:35,600 AND OPERATIONAL ISSUES THAT ARE 5169 03:46:35,600 --> 03:46:36,480 HOLDING US BACK. 5170 03:46:36,480 --> 03:46:39,320 OR TO GET MORE INFORMATION ON 5171 03:46:39,320 --> 03:46:40,640 THE OPPORTUNITIES THAT WE REALLY 5172 03:46:40,640 --> 03:46:42,720 NEED TO PAY ATTENTION TO. 5173 03:46:42,720 --> 03:46:48,720 WE'VE GOT A TON OF FEEDBACK. 5174 03:46:48,720 --> 03:46:51,600 IT'S BEEN INFORMATIVE AND I 5175 03:46:51,600 --> 03:46:53,440 DON'T KNOW IF I'M SURPRISED BUT 5176 03:46:53,440 --> 03:46:54,960 IT'S REALLY INTERESTING HOW AT A 5177 03:46:54,960 --> 03:46:56,880 CERTAIN LEVEL IT'S VERY 5178 03:46:56,880 --> 03:46:58,160 CONSISTENT, WHAT WE'RE HEARING 5179 03:46:58,160 --> 03:46:59,960 ABOUT THINGS WE NEED PAY 5180 03:46:59,960 --> 03:47:02,400 ATTENTION TO. 5181 03:47:02,400 --> 03:47:03,840 WE'RE NOT DONE YET. 5182 03:47:03,840 --> 03:47:06,800 AS WE DID AT THE ROUNDTABLE, 5183 03:47:06,800 --> 03:47:08,680 WE'RE TRYING TO GIVE YOU AS MANY 5184 03:47:08,680 --> 03:47:10,400 OPPORTUNITIES TO TELL US WHAT 5185 03:47:10,400 --> 03:47:13,040 YOU THINK WE NEED TO FOCUS ON 5186 03:47:13,040 --> 03:47:17,880 THROUGH OUR RFI, WE HAVE A 5187 03:47:17,880 --> 03:47:20,720 MAILBOX, I HEARD A LOT OF 5188 03:47:20,720 --> 03:47:23,000 SUGGESTIONS FOR ADDITIONAL 5189 03:47:23,000 --> 03:47:24,320 ROUNDTABLES, BUT AT SOME POINT 5190 03:47:24,320 --> 03:47:26,720 WE'LL HAVE TO PUT PEN TO PAPER 5191 03:47:26,720 --> 03:47:28,280 AND GET THIS DONE. 5192 03:47:28,280 --> 03:47:30,960 MEREDITH, DO YOU HAVE ANYTHING? 5193 03:47:30,960 --> 03:47:33,400 >>NO, I THINK YOU HIT THE NAIL 5194 03:47:33,400 --> 03:47:35,160 ON THE HEAD, PENNY. 5195 03:47:35,160 --> 03:47:37,680 WE'RE TRYING TO THINK HOW DO WE 5196 03:47:37,680 --> 03:47:39,080 KEEP HONING THIS AND GOING 5197 03:47:39,080 --> 03:47:39,400 DEEPER. 5198 03:47:39,400 --> 03:47:41,040 ONE OF THE THINGS WE'RE GOING TO 5199 03:47:41,040 --> 03:47:44,000 BE THINKING ABOUT IS WHAT LEVEL 5200 03:47:44,000 --> 03:47:45,680 WITHIN THE STRATEGIC PLAN IN 5201 03:47:45,680 --> 03:47:47,320 TERMS OF DEPTH AND SPECIFICITY 5202 03:47:47,320 --> 03:47:48,520 DO WE WANT TO STRIKE. 5203 03:47:48,520 --> 03:47:50,440 SO WE'LL BE THINKING ABOUT THAT 5204 03:47:50,440 --> 03:47:52,400 AS WELL AND WELCOME YOUR 5205 03:47:52,400 --> 03:47:56,120 THOUGHTS FROM THAT PERSPECTIVE 5206 03:47:56,120 --> 03:47:56,520 AS WELL. 5207 03:47:56,520 --> 03:47:58,960 >> ROBIN, I SEE YOUR HAND. 5208 03:47:58,960 --> 03:48:01,800 PLEASE GO AHEAD. 5209 03:48:01,800 --> 03:48:03,000 >> YES, THANKS. 5210 03:48:03,000 --> 03:48:06,080 I'VE BEEN VERY IMPRESSED SO FAR. 5211 03:48:06,080 --> 03:48:11,120 PERHAPS AS YOU MOVE FORWARD, 5212 03:48:11,120 --> 03:48:13,800 OPERATIONALLY, YOU WANT TO -- 5213 03:48:13,800 --> 03:48:18,200 NCATS IS DOING THING FASTER, THE 5214 03:48:18,200 --> 03:48:18,440 MANTRA. 5215 03:48:18,440 --> 03:48:20,000 IF YOU OPERATIONALIZE THE PARTS 5216 03:48:20,000 --> 03:48:21,520 OF THE STRATEGIC PLAN, IF THERE 5217 03:48:21,520 --> 03:48:24,680 ARE WAYS YOU COULD STREAMLINE 5218 03:48:24,680 --> 03:48:25,800 PROCESSES FOR HOW PEOPLE 5219 03:48:25,800 --> 03:48:29,160 INTERACT OR THE FACT THAT IT 5220 03:48:29,160 --> 03:48:33,040 TAKES 18 MONTHS TO GET SOMETHING 5221 03:48:33,040 --> 03:48:33,240 DONE. 5222 03:48:33,240 --> 03:48:35,000 IN OUR CURRENT WORLD AND WITH 5223 03:48:35,000 --> 03:48:37,840 COVID WE NEEDED SUCH RAPID 5224 03:48:37,840 --> 03:48:40,680 RESPONSES. 5225 03:48:40,680 --> 03:48:43,400 AND ARE THERE WAYS THAT -- AND I 5226 03:48:43,400 --> 03:48:46,040 KNOW WE MAY THIS MAY NOT BE 5227 03:48:46,040 --> 03:48:50,600 WITHIN YOUR CONTROL BUT 5228 03:48:50,600 --> 03:48:52,680 FACILITATING PROCESSES TO ALLOW 5229 03:48:52,680 --> 03:48:55,240 FOR TRULY TIME SENSITIVE RAPID 5230 03:48:55,240 --> 03:48:57,640 RESPONDING THAT DOESN'T TAKE TWO 5231 03:48:57,640 --> 03:48:59,560 YEARS TO GO FROM IDEA TO 5232 03:48:59,560 --> 03:49:07,280 IMPLEMENTATION AND BY THE TIME 5233 03:49:07,280 --> 03:49:08,680 IT'S DONE, IT'S IRRELEVANT. 5234 03:49:08,680 --> 03:49:11,640 >> IT'S A GREAT POINT. 5235 03:49:11,640 --> 03:49:15,360 IT USED TO BE A COUPLE YEARS AGO 5236 03:49:15,360 --> 03:49:17,560 THAT NCATS WAS THE ONLY I.C. 5237 03:49:17,560 --> 03:49:19,760 THAT USED THE SORT OF NEWER 5238 03:49:19,760 --> 03:49:20,600 MECHANISM CALLED THE OTHER 5239 03:49:20,600 --> 03:49:21,840 TRANSACTION AUTHORITY WHICH WAS 5240 03:49:21,840 --> 03:49:25,760 SUPPOSED TO HELP THINGS MOVE 5241 03:49:25,760 --> 03:49:27,080 FASTER, AND WE HAD THAT 5242 03:49:27,080 --> 03:49:28,840 AUTHORITY THROUGH THE CURES 5243 03:49:28,840 --> 03:49:29,480 ACCELERATION NETWORK PROGRAM BUT 5244 03:49:29,480 --> 03:49:31,120 IT WAS CAPPED AND STILL IS 5245 03:49:31,120 --> 03:49:31,360 CAPPED. 5246 03:49:31,360 --> 03:49:33,240 SO WE CAN ONLY USE IT TO A 5247 03:49:33,240 --> 03:49:35,000 CERTAIN DEGREE. 5248 03:49:35,000 --> 03:49:37,040 WE'RE HOPING -- THOSE ARE THE 5249 03:49:37,040 --> 03:49:38,040 KINDS OF THINGS WE'RE LEARNING 5250 03:49:38,040 --> 03:49:38,240 FROM. 5251 03:49:38,240 --> 03:49:39,800 IF THERE ARE WAYS WE CAN START 5252 03:49:39,800 --> 03:49:45,160 TO FIGURE OUT HOW TO EXPAND 5253 03:49:45,160 --> 03:49:47,160 THAT, THAT'S ONE SMALL EXAMPLE. 5254 03:49:47,160 --> 03:49:49,320 THERE ARE MANY OTHERS WHERE I 5255 03:49:49,320 --> 03:49:50,520 THINK WE HAVE LESSONS LEARNED WE 5256 03:49:50,520 --> 03:49:53,600 NEED TO MAKE SURE WE CAN APPLY. 5257 03:49:53,600 --> 03:49:56,400 SO, YEAH, I TAKE YOUR POINT VERY 5258 03:49:56,400 --> 03:50:02,240 WELL THAT NOT LOSING SITE ON 5259 03:50:02,240 --> 03:50:03,840 HELPING WITH THE PROCESS PIECE 5260 03:50:03,840 --> 03:50:04,720 IS IMPORTANT. 5261 03:50:04,720 --> 03:50:10,960 ANNA, DID YOU HAVE A COMMENT ON 5262 03:50:10,960 --> 03:50:11,160 THAT? 5263 03:50:11,160 --> 03:50:12,400 >> AS DIRECTOR OF DIVISION OF 5264 03:50:12,400 --> 03:50:14,080 EXTRAMURAL ACTIVITY I CAN SAY 5265 03:50:14,080 --> 03:50:17,000 WITH CONFIDENCE WE CAN IN FACT 5266 03:50:17,000 --> 03:50:17,760 MOVE QUICKLY. 5267 03:50:17,760 --> 03:50:20,160 AND WE CAN STREAMLINE THE 5268 03:50:20,160 --> 03:50:20,640 PROCESS. 5269 03:50:20,640 --> 03:50:23,000 ALWAYS HAVE THOSE OPTIONS. 5270 03:50:23,000 --> 03:50:25,560 I THINK UNDER COVID WITH 5271 03:50:25,560 --> 03:50:27,280 FLEXIBILITIES WE MAXED OUT. 5272 03:50:27,280 --> 03:50:29,800 THE ISSUE IS WHETHER WE CAN 5273 03:50:29,800 --> 03:50:32,000 CONTINUE TO MOVE AS EXPEDITIOUSY 5274 03:50:32,000 --> 03:50:32,440 WITHOUT THAT. 5275 03:50:32,440 --> 03:50:35,600 THE ANSWER IS MORE THAN WE WOULD 5276 03:50:35,600 --> 03:50:35,800 THINK. 5277 03:50:35,800 --> 03:50:39,440 THE ISSUE IS WHETHER OR NOT WE 5278 03:50:39,440 --> 03:50:41,720 HAVE THE SURGE CAPACITY AND 5279 03:50:41,720 --> 03:50:42,720 WHETHER IT'S SUSTAINABLE. 5280 03:50:42,720 --> 03:50:44,640 >> WE ALL EXPERIENCED THAT AT 5281 03:50:44,640 --> 03:50:46,120 UNIVERSITIES, WE HAD TO DO 5282 03:50:46,120 --> 03:50:46,520 EXACTLY THAT. 5283 03:50:46,520 --> 03:50:49,840 THERE ARE A LOT OF LESSONS WE 5284 03:50:49,840 --> 03:50:50,720 LEARNED. 5285 03:50:50,720 --> 03:50:56,080 MAYBE I DIDN'T NEED TO DO THIS. 5286 03:50:56,080 --> 03:50:58,880 WE'VE LEARNED FROM THAT. 5287 03:50:58,880 --> 03:51:00,800 >>ONE THING I WOULD SAY THAT I 5288 03:51:00,800 --> 03:51:02,400 DIDN'T HAVE A CHANCE TO SAY 5289 03:51:02,400 --> 03:51:06,440 BEFORE I WAS LOOKING AT THE 5290 03:51:06,440 --> 03:51:08,960 STAKEHOLDERS THAT HAVE INTN 5291 03:51:08,960 --> 03:51:10,280 ENGAGED TO CONTRIBUTE TO THE 5292 03:51:10,280 --> 03:51:11,680 STRATEGIC PLAN, IT DIDN'T SEEM 5293 03:51:11,680 --> 03:51:16,080 TO ME THAT THE LEADING VENTURE 5294 03:51:16,080 --> 03:51:19,280 CAPITAL FIRMS WERE SPOKEN TO AND 5295 03:51:19,280 --> 03:51:22,000 I THINK THAT THEY ARE AN 5296 03:51:22,000 --> 03:51:23,880 IMPORTANT VOICE TO CONSIDER 5297 03:51:23,880 --> 03:51:26,800 BECAUSE NCATS HAS SUCH AN 5298 03:51:26,800 --> 03:51:29,840 INCREDIBLE REPUTATION FOR 5299 03:51:29,840 --> 03:51:31,760 ADVANCED TECHNOLOGIES, THE TOP 5300 03:51:31,760 --> 03:51:37,000 TIER B.C.s ARE MAKING OVER THE 5301 03:51:37,000 --> 03:51:40,240 HORIZON TECHNOLOGY BETS THAT 5302 03:51:40,240 --> 03:51:45,320 UNDERSTANDING WHAT THEY ARE 5303 03:51:45,320 --> 03:51:52,480 SEEING, IT WOULD BE INFORMATIVE. 5304 03:51:52,480 --> 03:51:53,880 >> I'M ASSUMING THAT'S KELLY. 5305 03:51:53,880 --> 03:51:58,680 I CAN'T SEE YOU, BUT I HEAR YOU. 5306 03:51:58,680 --> 03:52:01,400 I WOULD LOVE TO FOLLOW UP WITH 5307 03:52:01,400 --> 03:52:01,920 YOU ON THAT. 5308 03:52:01,920 --> 03:52:03,480 >> OKAY. 5309 03:52:03,480 --> 03:52:04,280 >>SO STAY TUNED. 5310 03:52:04,280 --> 03:52:07,800 >>OKAY. 5311 03:52:07,800 --> 03:52:08,400 SOUND GOOD. 5312 03:52:08,400 --> 03:52:10,360 >> THANK YOU. 5313 03:52:10,360 --> 03:52:10,560 PENNY? 5314 03:52:10,560 --> 03:52:12,560 >> WE CERTAINLY NEED TO -- WE 5315 03:52:12,560 --> 03:52:14,640 COULD CERTAINLY USE SOME HELP ON 5316 03:52:14,640 --> 03:52:15,640 DIFFERENT STRATEGIES FOR 5317 03:52:15,640 --> 03:52:19,800 OUTREACH AS WE CONTINUE ON TO 5318 03:52:19,800 --> 03:52:22,640 MAKE SURE THAT WE DON'T LEAVE 5319 03:52:22,640 --> 03:52:23,240 ANYBODY BEHIND. 5320 03:52:23,240 --> 03:52:26,080 >> HAPPY TO HELP IN THE AREAS 5321 03:52:26,080 --> 03:52:32,480 WHERE I'M ABLE TO. 5322 03:52:32,480 --> 03:52:33,480 >> AND ANNIE? 5323 03:52:33,480 --> 03:52:36,200 >> SO, I WILL CERTAINLY RESPOND 5324 03:52:36,200 --> 03:52:37,840 TO THE MAILBOX, PARTICIPATE IN 5325 03:52:37,840 --> 03:52:39,600 FUTURE CONVERSATIONS BUT MAYBE A 5326 03:52:39,600 --> 03:52:41,920 COUPLE THINGS TOP OF MIND RIGHT 5327 03:52:41,920 --> 03:52:44,960 NOW, TO YOUR LIST OF QUESTIONS, 5328 03:52:44,960 --> 03:52:45,200 JONI. 5329 03:52:45,200 --> 03:52:47,040 MY FIRST RESPONSE TO THE 5330 03:52:47,040 --> 03:52:49,360 QUESTION AROUND RISK IS TAKE 5331 03:52:49,360 --> 03:52:49,560 RISKS. 5332 03:52:49,560 --> 03:52:50,080 FAIL FAST. 5333 03:52:50,080 --> 03:52:51,960 THIS IS THE PLACE THAT CAN 5334 03:52:51,960 --> 03:52:52,280 HAPPEN. 5335 03:52:52,280 --> 03:52:56,880 AND THIS IS THE PLACE WHERE WE 5336 03:52:56,880 --> 03:52:57,680 DE-RISK THE ENVIRONMENT, 5337 03:52:57,680 --> 03:52:58,880 STAKEHOLDERS OUTSIDE OF HERE. 5338 03:52:58,880 --> 03:53:02,520 THAT WOULD BE MY GUT RESPONSE TO 5339 03:53:02,520 --> 03:53:02,720 THAT. 5340 03:53:02,720 --> 03:53:05,320 AND THEN I WANT TO -- I JOTTED 5341 03:53:05,320 --> 03:53:08,400 DOWN, JUST SOME QUICK NOTES FROM 5342 03:53:08,400 --> 03:53:10,080 THINGS WE'VE HEARD TODAY, 5343 03:53:10,080 --> 03:53:13,360 HIGHLIGHTS FROM THINGS SEEN AND 5344 03:53:13,360 --> 03:53:18,520 HEARD TODAY RELATING TO EXACT. 5345 03:53:18,520 --> 03:53:23,040 NOT COMPREHENSIVE, JUST FROM MY 5346 03:53:23,040 --> 03:53:23,280 LENS. 5347 03:53:23,280 --> 03:53:26,040 DCRN CRATED TO EIGHT TREATMENTS, 5348 03:53:26,040 --> 03:53:29,840 CURE I.D. IS LEADING IN 5349 03:53:29,840 --> 03:53:30,600 PARTNERSHIP WITH FDA. 5350 03:53:30,600 --> 03:53:33,240 WE GET TO DO THE SCIENCE, PHARMA 5351 03:53:33,240 --> 03:53:35,760 ISN'T ALLOWED TO DO. 5352 03:53:35,760 --> 03:53:37,840 WE'VE BEEN EDING ANTI-VIRAL 5353 03:53:37,840 --> 03:53:39,800 PROGRAMS IN PREPAREDNESS FOR 5354 03:53:39,800 --> 03:53:43,160 FUTURE PANDEMICS. 5355 03:53:43,160 --> 03:53:44,520 SAW IT DOWNSTAIRS, A NUMBER 5356 03:53:44,520 --> 03:53:51,400 OF -- I'M GOING TO CALL THEM 5357 03:53:51,400 --> 03:53:53,440 AMAZING ROBOTS, INCREASING 5358 03:53:53,440 --> 03:53:55,040 ACCURACY AND EFFICIENCY, SAVING 5359 03:53:55,040 --> 03:53:56,840 THE ENVIRONMENT, REDUCING WASTE, 5360 03:53:56,840 --> 03:53:57,680 CONTRIBUTING TO CLINICAL TRIALS 5361 03:53:57,680 --> 03:53:58,960 THROUGHOUT THE NATION. 5362 03:53:58,960 --> 03:54:00,520 HELPING FIGHT OUR NATION'S 5363 03:54:00,520 --> 03:54:02,800 BIGGEST HEALTH CRISES FROM THE 5364 03:54:02,800 --> 03:54:06,880 OPIOID EPIDEMIC TO RARE DISEASE. 5365 03:54:06,880 --> 03:54:11,520 THAT'S NOT GETTING MESSAGED. 5366 03:54:11,520 --> 03:54:12,400 AND OUTSIDE STAKEHOLDER 5367 03:54:12,400 --> 03:54:13,280 ENVIRONMENT, DON'T UNDERSTAND 5368 03:54:13,280 --> 03:54:15,160 WHAT'S HAPPENING. 5369 03:54:15,160 --> 03:54:17,960 FROM MY UNDERSTANDING, ALL OF 5370 03:54:17,960 --> 03:54:19,920 THAT'S HAPPENING WITH ABOUT -- 5371 03:54:19,920 --> 03:54:24,600 WITHIN 32% OF THE NCATS BUDGET. 5372 03:54:24,600 --> 03:54:27,240 THAT'S NOT PART OF THE PROGRAM. 5373 03:54:27,240 --> 03:54:30,120 AS YOU'RE WORKING ON THE 5374 03:54:30,120 --> 03:54:38,120 STRATEGIC PLAN, SPEND A LOT OF 5375 03:54:38,120 --> 03:54:39,800 TIME ON OPTIMIZING IMPACT AND 5376 03:54:39,800 --> 03:54:43,240 INFLUENCE AND PULLING US IN. 5377 03:54:43,240 --> 03:54:44,040 >>COMMUNICATING. 5378 03:54:44,040 --> 03:54:44,320 >> UH-HUH. 5379 03:54:44,320 --> 03:54:45,040 >> FANTASTIC. 5380 03:54:45,040 --> 03:54:45,920 THANK YOU. 5381 03:54:45,920 --> 03:54:49,520 I WROTE DOWN QUITE A LOT ON 5382 03:54:49,520 --> 03:54:53,360 THAT. 5383 03:54:53,360 --> 03:54:56,840 THANK YOU. 5384 03:54:56,840 --> 03:54:57,080 SERGIO? 5385 03:54:57,080 --> 03:55:01,320 >> YES, I'M LOOKING AT THE 5386 03:55:01,320 --> 03:55:02,440 STRATEGIC PLANNING PROCESS, AND 5387 03:55:02,440 --> 03:55:08,040 IT'S A VERY TOUGH PROCESS, BY 5388 03:55:08,040 --> 03:55:14,120 THE WAY. 5389 03:55:14,120 --> 03:55:14,720 STAKEHOLDER ENGAGEMENT AND 5390 03:55:14,720 --> 03:55:21,240 LOOKING AT THE WONDERFUL IDEA OF 5391 03:55:21,240 --> 03:55:24,360 HAVING THE RFI TO RECEIVE 5392 03:55:24,360 --> 03:55:24,680 INFORMATION. 5393 03:55:24,680 --> 03:55:29,280 WHEN YOU SAY GATHER FEEDBACK, 5394 03:55:29,280 --> 03:55:33,000 THAT'S WHEN YOU START OUTLINING 5395 03:55:33,000 --> 03:55:34,200 AND DRAFTING THE PLAN. 5396 03:55:34,200 --> 03:55:36,360 CAN YOU SPEAK MORE ABOUT THAT? 5397 03:55:36,360 --> 03:55:41,280 BECAUSE THERE ARE GREAT 5398 03:55:41,280 --> 03:55:43,040 OPPORTUNITIES THERE TO NOT ONLY 5399 03:55:43,040 --> 03:55:46,000 IDENTIFY GROUPS THAT HAVE 5400 03:55:46,000 --> 03:55:47,880 PROVIDED INPUT, YOU GO BACK TO 5401 03:55:47,880 --> 03:55:50,280 THOSE PEOPLE AND LET THEM KNOW 5402 03:55:50,280 --> 03:55:56,960 THIS IS WHAT WE HEARD. 5403 03:55:56,960 --> 03:55:58,480 YOU HAVE FURTHER COMMENTS, AND 5404 03:55:58,480 --> 03:56:01,680 ANYTHING ELSE YOU CAN THINK OF, 5405 03:56:01,680 --> 03:56:04,520 NOW YOU'RE THINKING OF. 5406 03:56:04,520 --> 03:56:06,840 SO YOU PROVIDE FEEDBACK ON THE 5407 03:56:06,840 --> 03:56:10,840 FEEDBACK THAT YOU GET. 5408 03:56:10,840 --> 03:56:13,280 AND THE OPPORTUNITY THAT I SEE 5409 03:56:13,280 --> 03:56:17,200 THERE IS THAT YOU CAN HAVE A 5410 03:56:17,200 --> 03:56:27,560 GROUP THAT CAN BE YOUR 5411 03:56:28,640 --> 03:56:29,760 DISSEMINATION AGENTS. 5412 03:56:29,760 --> 03:56:32,960 SO, I THINK CREATING THOSE LIFTS 5413 03:56:32,960 --> 03:56:35,800 OF NOT ONLY THOSE THAT YOU 5414 03:56:35,800 --> 03:56:41,840 ALREADY HAVE BEEN WORKING WITH 5415 03:56:41,840 --> 03:56:50,120 BUT THE IDEA HERE LIKE THINGS I 5416 03:56:50,120 --> 03:56:53,400 HEARD AS WELL, TAPPING INTO 5417 03:56:53,400 --> 03:56:55,280 INDUSTRY, OTHER GROUPS, SO WOULD 5418 03:56:55,280 --> 03:57:03,560 BE VERY HELPFUL, AT LEAST FOR 5419 03:57:03,560 --> 03:57:08,280 ME, IF YOU HAVE IN TERMS OF 5420 03:57:08,280 --> 03:57:11,080 TIMELINES, PLANNING PROCESS, YOU 5421 03:57:11,080 --> 03:57:14,080 CAN BE FAT A LITTLE BIT MORE AND 5422 03:57:14,080 --> 03:57:17,680 INCLUDE DISSEMINATION THERE IN A 5423 03:57:17,680 --> 03:57:24,280 WAY THAT YOU WILL ONCE AGAIN 5424 03:57:24,280 --> 03:57:28,880 MAXIMIZE, OPTIMIZE, YOU KNOW, 5425 03:57:28,880 --> 03:57:30,040 STRATEGIC PLAN. 5426 03:57:30,040 --> 03:57:33,560 A STRATEGIC PLAN AS WELL. 5427 03:57:33,560 --> 03:57:35,880 >> I THINK JONI CALLS THIS A 5428 03:57:35,880 --> 03:57:36,280 CO-DESIGN. 5429 03:57:36,280 --> 03:57:38,800 WE'RE ONE PART OF IT AND YOU ARE 5430 03:57:38,800 --> 03:57:39,720 THE OTHER PART. 5431 03:57:39,720 --> 03:57:43,840 I THINK WE CALL THIS AN UPDATE. 5432 03:57:43,840 --> 03:57:45,840 COMING BACK TO YOU AT THE NEXT 5433 03:57:45,840 --> 03:57:47,160 COUNCIL I'M SURE. 5434 03:57:47,160 --> 03:57:51,840 THIS IS A LONG PROCESS BECAUSE 5435 03:57:51,840 --> 03:57:54,080 IT REALLY HELPS US REALLY 5436 03:57:54,080 --> 03:57:55,360 DEVELOP SOME PRIORITIES FOR 5437 03:57:55,360 --> 03:57:57,200 MOVING FORWARD OVER THE NEXT 5 5438 03:57:57,200 --> 03:57:59,400 TO 10 YEARS AND IT'S REALLY -- 5439 03:57:59,400 --> 03:58:01,480 YOU'RE GOING TO BE A BIG PART OF 5440 03:58:01,480 --> 03:58:04,560 MAKING SURE THAT WE GET THIS 5441 03:58:04,560 --> 03:58:05,000 RIGHT. 5442 03:58:05,000 --> 03:58:08,280 WHEN WE DESIGNED OUR FIRST PLAN 5443 03:58:08,280 --> 03:58:11,120 IN 2016 NCATS WAS SO NEW WE WERE 5444 03:58:11,120 --> 03:58:13,200 TRYING TO ESTABLISH OUR IDENTITY 5445 03:58:13,200 --> 03:58:15,400 WITHIN THE NIH. 5446 03:58:15,400 --> 03:58:18,600 AND ALSO TO REALLY CONNECT WITH 5447 03:58:18,600 --> 03:58:19,880 NOT ONLY THE SCIENTIFIC 5448 03:58:19,880 --> 03:58:22,200 COMMUNITY BUT REALLY THE NIH 5449 03:58:22,200 --> 03:58:25,040 COMMUNITY AS WELL. 5450 03:58:25,040 --> 03:58:27,760 AND I THINK THAT FIRST PLAN 5451 03:58:27,760 --> 03:58:30,480 INTERNALLY I THINK WE ALL FELT 5452 03:58:30,480 --> 03:58:35,200 LIKE IT FELT -- WE CALL IT 5453 03:58:35,200 --> 03:58:37,600 NCATS-IAN, FELT LIKE US, WHEN WE 5454 03:58:37,600 --> 03:58:40,560 HAD THAT WORD CLOUD DURING THE 5455 03:58:40,560 --> 03:58:42,120 PRESENTATION, THAT'S HOW WE 5456 03:58:42,120 --> 03:58:42,560 FELT. 5457 03:58:42,560 --> 03:58:46,400 WE DID NOT KNOW IF THAT'S HOW WE 5458 03:58:46,400 --> 03:58:47,440 LOOKED EXTERNALLY. 5459 03:58:47,440 --> 03:58:50,080 SO I THINK THIS COMMUNICATION 5460 03:58:50,080 --> 03:58:53,480 AND THIS KIND OF ITERATIVE 5461 03:58:53,480 --> 03:58:55,040 PROCESS OF WORKING WITH YOU, 5462 03:58:55,040 --> 03:58:58,520 GOING TO THE NEXT STEPS, SAYING 5463 03:58:58,520 --> 03:59:00,680 ARE WE STILL -- THIS IS WHAT WE 5464 03:59:00,680 --> 03:59:02,440 THINK IS RIGHT, DOES IT LOOK 5465 03:59:02,440 --> 03:59:04,520 RIGHT TO YOU AND THAT WE'RE ON 5466 03:59:04,520 --> 03:59:06,520 TARGET, BUT I HEAR YOU LOUD AND 5467 03:59:06,520 --> 03:59:06,920 CLEAR. 5468 03:59:06,920 --> 03:59:10,320 I THINK ALL OF YOU. 5469 03:59:10,320 --> 03:59:12,400 ABOUT THE DISSEMINATION AND THE 5470 03:59:12,400 --> 03:59:15,880 OUTREACH AND COMMUNICATION AS WE 5471 03:59:15,880 --> 03:59:16,040 GO. 5472 03:59:16,040 --> 03:59:22,800 >> ONE LAST THING, AND, JONI, 5473 03:59:22,800 --> 03:59:24,040 YOU SAID SOMETHING THAT BROUGHT, 5474 03:59:24,040 --> 03:59:30,000 YOU KNOW, RESONATED VERY MUCH. 5475 03:59:30,000 --> 03:59:33,080 THAT IS THAT WORKING WITH AHRQ 5476 03:59:33,080 --> 03:59:35,760 AND OTHER AGENCIES TO LEVERAGE 5477 03:59:35,760 --> 03:59:37,880 AND SYNERGIZE WHAT CAN BE 5478 03:59:37,880 --> 03:59:42,360 SYNERGIZED, YOU KNOW, IS A GREAT 5479 03:59:42,360 --> 03:59:42,560 IDEA. 5480 03:59:42,560 --> 03:59:45,680 I WOULD LOVE TO SEE SOMETHING 5481 03:59:45,680 --> 03:59:50,000 LIKE THAT MORE PURPOSELY, SOME 5482 03:59:50,000 --> 03:59:53,080 OF THAT COORDINATION AND 5483 03:59:53,080 --> 03:59:54,800 INSPIRATION AS WELL BECAUSE, YOU 5484 03:59:54,800 --> 03:59:59,400 KNOW, YOU CANNOT DO EVERYTHING, 5485 03:59:59,400 --> 04:00:01,280 AS YOU MENTIONED. 5486 04:00:01,280 --> 04:00:04,800 BUT MAYBE THROUGH OTHER 5487 04:00:04,800 --> 04:00:06,840 INSTITUTES, FOR EXAMPLE, FOR 5488 04:00:06,840 --> 04:00:11,520 ALL, I'M THINKING ON THE 5489 04:00:11,520 --> 04:00:14,960 NATIONAL INSTITUTE FOR MENTAL 5490 04:00:14,960 --> 04:00:16,280 HEALTH, HEALTH DISPARITIES, FOR 5491 04:00:16,280 --> 04:00:20,160 EXAMPLE, AS WELL AS OTHER 5492 04:00:20,160 --> 04:00:23,320 INSTITUTES THAT CAN HELP WITH 5493 04:00:23,320 --> 04:00:29,680 THAT THREE-PART TYPE VISION YOU 5494 04:00:29,680 --> 04:00:30,400 HAVE, WONDERFUL VISION. 5495 04:00:30,400 --> 04:00:31,400 >> THANK YOU. 5496 04:00:31,400 --> 04:00:32,800 I AGREE. 5497 04:00:32,800 --> 04:00:34,600 WE DO HAVE OPPORTUNITIES EXPLORE 5498 04:00:34,600 --> 04:00:34,880 THAT. 5499 04:00:34,880 --> 04:00:38,760 WHERE WE HAVEN'T DONE THAT QUITE 5500 04:00:38,760 --> 04:00:38,960 YET. 5501 04:00:38,960 --> 04:00:41,280 SO I THINK WE HAVE STARTED 5502 04:00:41,280 --> 04:00:42,800 CONVERSATIONS AND THEY ARE 5503 04:00:42,800 --> 04:00:44,320 REALLY ABOUT SORT OF LEARNING 5504 04:00:44,320 --> 04:00:45,880 ABOUT ONE ANOTHER, GETTING TO 5505 04:00:45,880 --> 04:00:47,720 KNOW ONE ANOTHER, AND WE CAN 5506 04:00:47,720 --> 04:00:50,120 TAKE IT TO THE NEXT STEP HELPING 5507 04:00:50,120 --> 04:00:51,440 US ENGAGE IN THE STRATEGIC 5508 04:00:51,440 --> 04:00:52,880 PLANNING PROCESS. 5509 04:00:52,880 --> 04:00:58,440 I SEE THAT AS REALLY MORE OF AN 5510 04:00:58,440 --> 04:00:59,560 ITERATIVE PROCESS TOO WITH THOSE 5511 04:00:59,560 --> 04:01:00,840 KINDS OF GROUPS. 5512 04:01:00,840 --> 04:01:02,920 THE OTHER THING I WANT TO SAY, 5513 04:01:02,920 --> 04:01:04,800 I'LL LET MEREDITH CHIME IN, IN 5514 04:01:04,800 --> 04:01:06,560 TERMS OF THE FEEDBACK TO THE 5515 04:01:06,560 --> 04:01:08,520 FEEDBACK, I THINK PART OF THAT 5516 04:01:08,520 --> 04:01:11,360 WILL BE IN TERMS OF PROCESS FOR 5517 04:01:11,360 --> 04:01:14,200 US, THE INITIAL PIECE OF THAT 5518 04:01:14,200 --> 04:01:16,280 WILL PROBABLY BE IN THAT RFI AND 5519 04:01:16,280 --> 04:01:17,120 THAT WILL GO OUT. 5520 04:01:17,120 --> 04:01:20,960 THAT'S GOING TO BE OUR FIRST 5521 04:01:20,960 --> 04:01:22,600 STAB AT DISTILLATION OF THE 5522 04:01:22,600 --> 04:01:23,720 INPUT WE RECEIVE. 5523 04:01:23,720 --> 04:01:26,760 IN A WAY WE'LL BE ABLE TO 5524 04:01:26,760 --> 04:01:28,040 DISTILL THAT IN THE RFI, FEED 5525 04:01:28,040 --> 04:01:29,520 THAT BACK TO THE COMMUNITY AND 5526 04:01:29,520 --> 04:01:31,800 SAY, HERE, THIS IS WHAT WE'VE 5527 04:01:31,800 --> 04:01:33,440 HEARD, DID WE GET IT RIGHT? 5528 04:01:33,440 --> 04:01:36,400 WHAT PARTS DID WE GET RIGHT AND 5529 04:01:36,400 --> 04:01:36,640 WRONG? 5530 04:01:36,640 --> 04:01:38,040 AND NOW THAT YOU'VE HAD A CHANCE 5531 04:01:38,040 --> 04:01:40,440 TO THINK ABOUT IT WHAT ELSE ARE 5532 04:01:40,440 --> 04:01:41,240 YOU THINKING ABOUT? 5533 04:01:41,240 --> 04:01:44,480 IT WILL KIND OF COVER THE GAMUT 5534 04:01:44,480 --> 04:01:48,000 OF THOSE WAYS OF PROVIDING THE 5535 04:01:48,000 --> 04:01:49,440 FEEDBACK BACK TO THEM AND THEN 5536 04:01:49,440 --> 04:01:50,880 ASKING THEM, YOU KNOW, HOW DID 5537 04:01:50,880 --> 04:01:51,640 WE DO. 5538 04:01:51,640 --> 04:01:53,040 SO I'M HOPING THERE WILL BE SOME 5539 04:01:53,040 --> 04:01:54,920 OF THAT BUILT INTO THE -- EVEN 5540 04:01:54,920 --> 04:01:57,400 IN THIS EARLY PHASE OF THE RFI 5541 04:01:57,400 --> 04:01:58,840 PIECE AND WE CAN PERHAPS EVEN 5542 04:01:58,840 --> 04:02:02,680 CONTINUE TO DO SOME OF THOSE KEY 5543 04:02:02,680 --> 04:02:04,960 ENGAGEMENT ALSO WHERE IT MAKES 5544 04:02:04,960 --> 04:02:06,080 SENSE WHERE MAYBE WE WEREN'T 5545 04:02:06,080 --> 04:02:07,680 QUITE SPOT ON AND GO BACK AND 5546 04:02:07,680 --> 04:02:08,800 MAKE SURE THAT WE'RE 5547 04:02:08,800 --> 04:02:10,520 UNDERSTANDING WHERE WE CAN MAKE 5548 04:02:10,520 --> 04:02:11,320 THAT PROGRESS. 5549 04:02:11,320 --> 04:02:13,160 SO THOSE ARE SOME OF THE 5550 04:02:13,160 --> 04:02:15,120 STRATEGIES THAT WE'LL DO OR 5551 04:02:15,120 --> 04:02:17,320 TACTICS I SHOULD SAY FOR THE 5552 04:02:17,320 --> 04:02:17,840 STRATEGIC PLAN. 5553 04:02:17,840 --> 04:02:18,880 MEREDITH, DID YOU HAVE SOMETHING 5554 04:02:18,880 --> 04:02:21,920 TO ADD AND I'LL GO TO ANIKA? 5555 04:02:21,920 --> 04:02:24,520 >>YEAH, I'LL ADD QUICKLY, I 5556 04:02:24,520 --> 04:02:28,040 ECHO EVERYTHING YOU AND PENNY 5557 04:02:28,040 --> 04:02:28,280 SAID. 5558 04:02:28,280 --> 04:02:29,680 A COUPLE THINGS, MY PERMANENT 5559 04:02:29,680 --> 04:02:31,240 APPROACH TO THIS TYPE OF 5560 04:02:31,240 --> 04:02:33,960 ACTIVITY IS VERY MUCH AN 5561 04:02:33,960 --> 04:02:35,360 ITERATIVE AND FEEDBACK LOOPS. 5562 04:02:35,360 --> 04:02:39,080 AND IT REALLY DOES HAVE TO BE 5563 04:02:39,080 --> 04:02:40,280 BIDIRECTIONAL, NOT JUST US 5564 04:02:40,280 --> 04:02:42,680 TELLING YOU AND OTHER 5565 04:02:42,680 --> 04:02:44,560 STAKEHOLDERS BUT TAKING UP THE 5566 04:02:44,560 --> 04:02:45,040 FEEDBACK. 5567 04:02:45,040 --> 04:02:45,720 THAT'S SOMETHING, ALTHOUGH IT'S 5568 04:02:45,720 --> 04:02:49,160 HARD TO PUT IT IN A CHEVRON, YOU 5569 04:02:49,160 --> 04:02:50,680 KNOW, ON A SLIDE, IS VERY MUCH 5570 04:02:50,680 --> 04:02:53,960 AT THE CORE OF HOW WE THINK 5571 04:02:53,960 --> 04:02:56,000 ABOUT AND ARE APPROACHING THE 5572 04:02:56,000 --> 04:02:56,800 STRATEGIC PLAN. 5573 04:02:56,800 --> 04:02:59,200 IN TERMS OF TACTICS LIKE YOU 5574 04:02:59,200 --> 04:03:01,160 SAID, JONI, YOU KNOW, WE WEREN'T 5575 04:03:01,160 --> 04:03:03,280 SURE WHEN WE STARTED THIS AND WE 5576 04:03:03,280 --> 04:03:05,600 WANTED TO STAY OPEN MINDED, AND 5577 04:03:05,600 --> 04:03:08,160 SORT OF OPEN TO THE PROCESS, 5578 04:03:08,160 --> 04:03:11,560 PLAYING OUT IN FRONT OF US 5579 04:03:11,560 --> 04:03:13,640 INSTEAD OF PRE-DECIDING A PATH. 5580 04:03:13,640 --> 04:03:15,960 WE WEREN'T SURE WHAT THE RFI WAS 5581 04:03:15,960 --> 04:03:17,800 GOING TO LOOK LIKE, WHETHER MORE 5582 04:03:17,800 --> 04:03:19,800 QUESTIONS, BASED ON THE 5583 04:03:19,800 --> 04:03:21,280 ROUNDTABLE, AND WE WANTED TO 5584 04:03:21,280 --> 04:03:22,040 PROBE THAT. 5585 04:03:22,040 --> 04:03:24,040 WHAT PENNEY AND I AND THE TEAM 5586 04:03:24,040 --> 04:03:26,360 ARE THINKING NOW IS WE'VE GOTTEN 5587 04:03:26,360 --> 04:03:29,000 SUCH RICHNESS FROM ALL OF THESE 5588 04:03:29,000 --> 04:03:30,280 ROUNDTABLES AND OTHER MEETINGS 5589 04:03:30,280 --> 04:03:34,760 THAT WE PROBABLY HAVE A FAIR 5590 04:03:34,760 --> 04:03:37,080 AMOUNT THAT WE CAN THEN REFLECT 5591 04:03:37,080 --> 04:03:39,480 BACK IN THE RFI TO START KIND OF 5592 04:03:39,480 --> 04:03:42,000 GOING TO THAT NEXT LEVEL OF 5593 04:03:42,000 --> 04:03:44,840 DEPTH AND SAYING, OKAY, THIS IS 5594 04:03:44,840 --> 04:03:46,960 WHAT WE HEARD, NOW WHAT ARE WE 5595 04:03:46,960 --> 04:03:48,600 MISSING, WHAT DOES THIS LOOK 5596 04:03:48,600 --> 04:03:51,640 LIKE AS IT'S STARRING TO HONE. 5597 04:03:51,640 --> 04:03:52,600 THE OTHER PIECE, SERGIO, TO THE 5598 04:03:52,600 --> 04:03:54,040 POINT YOU WERE MAKING ABOUT 5599 04:03:54,040 --> 04:03:55,800 ENGAGING WITH THE OTHER I.C.s, 5600 04:03:55,800 --> 04:03:58,440 THERE'S SOME PIECES OF THAT THAT 5601 04:03:58,440 --> 04:03:59,280 HAPPENED ORGANICALLY BECAUSE THE 5602 04:03:59,280 --> 04:04:03,280 OTHER I.C.s ARE PART OF THE 5603 04:04:03,280 --> 04:04:05,720 PROCESS WHEN AN I.C. BUILDS A 5604 04:04:05,720 --> 04:04:07,160 STRATEGIC PLAN. 5605 04:04:07,160 --> 04:04:08,960 SO, THEY ACTUALLY ALL GET TO SEE 5606 04:04:08,960 --> 04:04:10,320 THE STRATEGIC PLAN, THEY WILL BE 5607 04:04:10,320 --> 04:04:12,320 PART OF THE LOOP IN. 5608 04:04:12,320 --> 04:04:16,480 ACTUALLY SOME OF THEM JOINED OUR 5609 04:04:16,480 --> 04:04:18,200 ROUNDTABLES, WE WERE PLEASED BY 5610 04:04:18,200 --> 04:04:18,560 THAT. 5611 04:04:18,560 --> 04:04:19,840 BUT THEY ALL DEFINITELY WILL BE 5612 04:04:19,840 --> 04:04:23,440 IN THE LOOP AND I HAVE FOUND, 5613 04:04:23,440 --> 04:04:25,200 AND I THINK, JONI, YOU WERE 5614 04:04:25,200 --> 04:04:26,720 PROBABLY -- IT WAS VERY EARLY 5615 04:04:26,720 --> 04:04:28,480 DAYS SO YOU WERE DEPUTY, YOU AND 5616 04:04:28,480 --> 04:04:30,240 I CAME ON BOARD ABOUT THE SAME 5617 04:04:30,240 --> 04:04:31,880 TIME, WOMEN'S HEALTH WAS DOING 5618 04:04:31,880 --> 04:04:34,000 THEIR STRATEGIC PLAN AND ENGAGED 5619 04:04:34,000 --> 04:04:36,280 US AND MIKE KURILLA AND I WORKED 5620 04:04:36,280 --> 04:04:37,920 WITH THEM ON THEIR PLAN. 5621 04:04:37,920 --> 04:04:39,920 SO, THERE ARE SOME OF THOSE 5622 04:04:39,920 --> 04:04:41,760 SYNERGIES BUILT INTO THE PROCESS 5623 04:04:41,760 --> 04:04:44,720 THAT WILL I THINK HELP US ALONG 5624 04:04:44,720 --> 04:04:47,240 THE WAY, YOU KNOW, FOSTERING 5625 04:04:47,240 --> 04:04:49,520 MORE RELATIONSHIPS BUT THERE'S A 5626 04:04:49,520 --> 04:04:51,720 LOT OF EXISTING RELATIONSHIPS 5627 04:04:51,720 --> 04:04:53,600 AMONGST OUR STAFF AND ACROSS 5628 04:04:53,600 --> 04:04:57,840 I.C.s THAT WILL BE HELPFUL AS 5629 04:04:57,840 --> 04:05:01,880 WE MOVE FORWARD IN SHAPING THE 5630 04:05:01,880 --> 04:05:02,120 PLAN. 5631 04:05:02,120 --> 04:05:02,600 THAT'S EVERYTHING. 5632 04:05:02,600 --> 04:05:08,280 >>THANK YOU FOR THAT. 5633 04:05:08,280 --> 04:05:08,480 ANIKA? 5634 04:05:08,480 --> 04:05:10,480 >> YEAH, I'M NOT SURE, IT WILL 5635 04:05:10,480 --> 04:05:11,760 BE INTERESTING TO SEE, I MEAN, 5636 04:05:11,760 --> 04:05:13,080 THE FIRST STRATEGIC PLAN READING 5637 04:05:13,080 --> 04:05:15,280 THROUGH IT, YOU KNOW, A LOT OF 5638 04:05:15,280 --> 04:05:19,160 WHAT YOU'RE DOING NOW IS IN LIE 5639 04:05:19,160 --> 04:05:21,240 AND YOU'VE DONE GREAT WORK SINCE 5640 04:05:21,240 --> 04:05:23,600 INCEPTION OF NCATS SO I'M NOT 5641 04:05:23,600 --> 04:05:30,720 SURE HOW MUCH YOU WANT WANT TO, 5642 04:05:30,720 --> 04:05:32,000 ESPECIALLY GIVEN THAT YOU LAID 5643 04:05:32,000 --> 04:05:33,240 ALL THESE GREAT PROGRAMS OUT BUT 5644 04:05:33,240 --> 04:05:36,320 I THINK TAKING THE RISK IS 5645 04:05:36,320 --> 04:05:38,640 IMPORTANT AND MAYBE THE WAY TO 5646 04:05:38,640 --> 04:05:40,720 BALANCE THAT IS BECAUSE OF THE 5647 04:05:40,720 --> 04:05:42,480 GREAT WORK YOU'VE DONE, IT GOES 5648 04:05:42,480 --> 04:05:45,280 BACK TO THE SAME THING, ENGAGING 5649 04:05:45,280 --> 04:05:47,840 PEEL, YOU'VE GOT GREAT IDEAS. 5650 04:05:47,840 --> 04:05:49,480 WE'VE CREATED ALL THESE 5651 04:05:49,480 --> 04:05:50,920 ACHIEVEMENTS FROM THE FIRST PLAN 5652 04:05:50,920 --> 04:05:54,360 BUT NOW WE SEE WHERE THERE'S 5653 04:05:54,360 --> 04:05:57,240 GAPS, MAYBE OTHER STAKEHOLDERS 5654 04:05:57,240 --> 04:05:59,600 WE HAVEN'T ENGAGED IN. 5655 04:05:59,600 --> 04:06:01,000 VENTURE CAPITALISTS, MORE 5656 04:06:01,000 --> 04:06:01,840 PRIVATE SECTOR, OTHERS, WILL 5657 04:06:01,840 --> 04:06:04,400 MANY INFORM YOU HOW DO WE TAKE 5658 04:06:04,400 --> 04:06:06,800 THIS FIRST STRATEGIC PLAN TO THE 5659 04:06:06,800 --> 04:06:10,840 NEXT LEVEL THAT IS MORE RISKY. 5660 04:06:10,840 --> 04:06:12,400 I ALSO HAVE THE SAME THOUGHT HOW 5661 04:06:12,400 --> 04:06:14,240 DO YOU BUILD THE STRATEGIC PLAN 5662 04:06:14,240 --> 04:06:15,880 NOW THAT ARPA-H IS CREATED SO 5663 04:06:15,880 --> 04:06:19,160 THAT'S GOING TO HAVE TO FACTOR 5664 04:06:19,160 --> 04:06:20,960 IN SO PROBABLY ON THE LIST YOU 5665 04:06:20,960 --> 04:06:26,840 TALKED ABOUT I.C.s, MIGHT BE 5666 04:06:26,840 --> 04:06:31,440 HELPFUL TO TALK TO HOW DOES 5667 04:06:31,440 --> 04:06:33,320 DoD INTERFACE WITH DARPA, AND 5668 04:06:33,320 --> 04:06:34,760 THEY DO A LOT OF PRODUCT 5669 04:06:34,760 --> 04:06:36,280 DEVELOPMENT AND MAY HAVE THINGS 5670 04:06:36,280 --> 04:06:37,600 TO GAIN, SAME WITH DEPARTMENT OF 5671 04:06:37,600 --> 04:06:38,560 ENERGY, THOSE COULD BE OTHER 5672 04:06:38,560 --> 04:06:40,080 PEOPLE YOU TALK TO AS WELL. 5673 04:06:40,080 --> 04:06:41,880 YOU HAVE GREAT FOUNDATION TO 5674 04:06:41,880 --> 04:06:43,920 BUILD UPON SO IT'S GOING TO BE 5675 04:06:43,920 --> 04:06:44,440 TOUGH TO PIVOT. 5676 04:06:44,440 --> 04:06:47,520 I DON'T KNOW IF YOU WANT TO DO A 5677 04:06:47,520 --> 04:06:48,520 FULL PIVOT OR INCREMENTAL 5678 04:06:48,520 --> 04:06:49,840 ADVANCES ON WHAT YOU'VE DONE 5679 04:06:49,840 --> 04:06:50,480 ALREADY. 5680 04:06:50,480 --> 04:06:54,760 IT WILL BE INTERESTING TO SEE. 5681 04:06:54,760 --> 04:06:56,400 >> YEAH, I THINK THAT THERE ARE 5682 04:06:56,400 --> 04:06:58,360 GOING TO BE ASPECTS WHERE WE'RE 5683 04:06:58,360 --> 04:07:00,920 GOING TO GO DEEPER BECAUSE NOW 5684 04:07:00,920 --> 04:07:02,080 WE KNOW MORE. 5685 04:07:02,080 --> 04:07:02,360 >> RIGHT. 5686 04:07:02,360 --> 04:07:05,160 >>WE HAVE REALLY LEARNED A LOT. 5687 04:07:05,160 --> 04:07:10,080 WE'VE LEARNED A LOT ABOUT DATA 5688 04:07:10,080 --> 04:07:10,760 SCIENCE. 5689 04:07:10,760 --> 04:07:15,240 WITH THE INFORMATICS, SDPI AND 5690 04:07:15,240 --> 04:07:15,560 THOSE THINGS. 5691 04:07:15,560 --> 04:07:16,200 GENE-TARGETED THERAPIES IS 5692 04:07:16,200 --> 04:07:18,920 SOMETHING WE DIDN'T HAVE A WHOLE 5693 04:07:18,920 --> 04:07:25,680 LOT OF IN THE FIRST PLAN. 5694 04:07:25,680 --> 04:07:29,320 AND TALKING ABOUT WHAT ARE THE 5695 04:07:29,320 --> 04:07:30,520 PRIORITIES, YOU KNOW. 5696 04:07:30,520 --> 04:07:32,600 I SEE IT THAT WAY BUT, AGAIN, WE 5697 04:07:32,600 --> 04:07:36,240 DID HAVE AND DID RECEIVE A LOT 5698 04:07:36,240 --> 04:07:38,960 OF COMMENTS ABOUT OTHER AREAS OR 5699 04:07:38,960 --> 04:07:43,120 OPPORTUNITIES TO ADDRESS. 5700 04:07:43,120 --> 04:07:46,520 >> IF YOU DON'T MIND, I'LL ADD 5701 04:07:46,520 --> 04:07:47,840 TO TO WHAT PEPPY WAS SAYING. 5702 04:07:47,840 --> 04:07:51,320 I PUT THIS IN THE CHAT. 5703 04:07:51,320 --> 04:07:53,160 WE'RE NOT IGNORING THAT PLAN IN 5704 04:07:53,160 --> 04:07:55,920 ANY WAY, SHAPE, OR FORM. 5705 04:07:55,920 --> 04:07:59,080 YOU KNOW, I THINK IT WAS DR. 5706 04:07:59,080 --> 04:08:00,840 RUTTER'S PURVIEW AS NEW 5707 04:08:00,840 --> 04:08:02,840 DIRECTOR, WANTED TO PUT HER 5708 04:08:02,840 --> 04:08:04,920 STAMP AND HER VISION ON THE PLAN 5709 04:08:04,920 --> 04:08:06,760 BUT I THINK FIRST OF ALL WE DO 5710 04:08:06,760 --> 04:08:08,960 WANT TO REFLECT BACK, THAT'S 5711 04:08:08,960 --> 04:08:10,560 EXPECTED AS TO WHERE DO WE COME 5712 04:08:10,560 --> 04:08:12,240 FROM AND WHAT HAVE WE DONE, 5713 04:08:12,240 --> 04:08:14,200 THERE'S ALSO AS YOU NOTED A LOT 5714 04:08:14,200 --> 04:08:16,720 OF RICHNESS IN THAT PLAN THAT WE 5715 04:08:16,720 --> 04:08:18,000 CAN BUILD ON. 5716 04:08:18,000 --> 04:08:20,560 AND SO WE'RE GOING TO BE LOOKING 5717 04:08:20,560 --> 04:08:25,840 AND FACTORING THAT INTO OUR 5718 04:08:25,840 --> 04:08:27,040 ANALYSIS AND SYNTHESIS OF THE 5719 04:08:27,040 --> 04:08:28,280 FEEDBACK AS WELL. 5720 04:08:28,280 --> 04:08:29,960 SO DEFINITELY WANT TO MAKE SURE 5721 04:08:29,960 --> 04:08:31,200 FOLKS DIDN'T THINK WE WERE 5722 04:08:31,200 --> 04:08:32,920 WORKING AWAY FROM THAT PLAN IN 5723 04:08:32,920 --> 04:08:35,520 ANY WAY, SHAPE, OR FORM. 5724 04:08:35,520 --> 04:08:41,760 >> BUILDING ON IT. 5725 04:08:41,760 --> 04:08:42,120 FIRM FOUNDATION. 5726 04:08:42,120 --> 04:08:42,640 >> THAT'S GREAT. 5727 04:08:42,640 --> 04:08:45,480 >> THANK YOU. 5728 04:08:45,480 --> 04:08:51,920 ANY OTHER COMMENTS? 5729 04:08:51,920 --> 04:08:52,600 OKAY. 5730 04:08:52,600 --> 04:08:54,440 I THINK WE'RE GETTING -- WE 5731 04:08:54,440 --> 04:08:58,240 MANAGED TO GO THROUGH TILL 5:30, 5732 04:08:58,240 --> 04:08:59,720 SO ALWAYS IMPRESSIVE. 5733 04:08:59,720 --> 04:09:01,240 I REALLY APPRECIATE YOUR 5734 04:09:01,240 --> 04:09:02,320 ENGAGEMENT. 5735 04:09:02,320 --> 04:09:03,520 I APPRECIATE YOUR ENGAGEMENT, 5736 04:09:03,520 --> 04:09:06,600 APPRECIATE YOUR INPUT, 5737 04:09:06,600 --> 04:09:07,640 APPRECIATE YOUR PARTNERSHIP. 5738 04:09:07,640 --> 04:09:12,920 I THINK THIS DISCUSSION HAS BEEN 5739 04:09:12,920 --> 04:09:13,920 INCREDIBLE. 5740 04:09:13,920 --> 04:09:14,720 >> I DON'T THINK WE'VE SAID 5741 04:09:14,720 --> 04:09:15,680 THANK YOU TO EVERYBODY. 5742 04:09:15,680 --> 04:09:17,000 NICE TO SEE EVERYBODY IN PERSON. 5743 04:09:17,000 --> 04:09:19,840 AT THE END OF THE DAY WHAT 5744 04:09:19,840 --> 04:09:21,280 YOU'RE PRESENTING IS THAT YOU'RE 5745 04:09:21,280 --> 04:09:23,360 SAVING AND CHANGING LIVES SO I 5746 04:09:23,360 --> 04:09:25,240 KNOW THESE ARE TECHNICAL 5747 04:09:25,240 --> 04:09:27,240 PRESENTATIONS BUT JUST THANK YOU 5748 04:09:27,240 --> 04:09:37,600 FOR THE WORK YOU DO. 5749 04:09:38,720 --> 04:09:39,320 IT'S BREATHTAKING. 5750 04:09:39,320 --> 04:09:40,000 >> EXTRAORDINARY, CONSISTENTLY, 5751 04:09:40,000 --> 04:09:42,600 IT'S AMAZING WE'RE EVEN VOTING 5752 04:09:42,600 --> 04:09:47,000 ON THIS. 5753 04:09:47,000 --> 04:09:50,680 KEEP DOING GREAT WORK. 5754 04:09:50,680 --> 04:09:50,960 [CROSSTALK] 5755 04:09:50,960 --> 04:09:52,440 >> IMPACTING SO THANK YOU. 5756 04:09:52,440 --> 04:09:57,040 >>THANK YOU VERY MUCH FOR THOSE 5757 04:09:57,040 --> 04:09:57,320 COMMENTS. 5758 04:09:57,320 --> 04:09:58,440 HEARTFELT, SO THANK YOU. 5759 04:09:58,440 --> 04:10:01,760 AND WE WON'T TAKE A VOTE ON 5760 04:10:01,760 --> 04:10:01,960 THAT. 5761 04:10:01,960 --> 04:10:04,960 I'LL JUST TAKE IT AS 5762 04:10:04,960 --> 04:10:05,280 APPRECIATION. 5763 04:10:05,280 --> 04:10:07,440 [LAUGHTER] 5764 04:10:07,440 --> 04:10:09,280 5765 04:10:09,280 --> 04:10:11,400 NEXT TIME I PROMISE TO BE THERE 5766 04:10:11,400 --> 04:10:15,200 IN PERSON, FOR CRYING OUT LOUD. 5767 04:10:15,200 --> 04:10:17,920 THIS HAS BEEN -- I ADMIT TO 5768 04:10:17,920 --> 04:10:21,760 HAVING A BIT OF FOMO, TEXTING 5769 04:10:21,760 --> 04:10:25,840 PEOPLE ALONG THE WAY, HOW IS 5770 04:10:25,840 --> 04:10:28,400 EVERYTHING GOING, AND NOT TO BE 5771 04:10:28,400 --> 04:10:31,800 CONFUSED WITH NOFO, THIS IS 5772 04:10:31,800 --> 04:10:32,000 FOMO. 5773 04:10:32,000 --> 04:10:38,520 [LAUGHTER] 5774 04:10:38,520 --> 04:10:42,880 >> JONI, ALSO, TO THANK ANNA 5775 04:10:42,880 --> 04:10:43,680 AND YOUR FULL TEAM. 5776 04:10:43,680 --> 04:10:45,840 [APPLAUSE] 5777 04:10:45,840 --> 04:10:50,760 5778 04:10:50,760 --> 04:10:53,080 >> YES, THANK YOU. 5779 04:10:53,080 --> 04:10:55,360 IT IS A PROCESS, I TELL YOU, TO 5780 04:10:55,360 --> 04:10:56,680 PULL THESE THING TOGETHER. 5781 04:10:56,680 --> 04:10:59,760 THEY DO A FABULOUS JOB FOR THE 5782 04:10:59,760 --> 04:11:01,920 WHOLE COUNCIL TEAM AND THE 5783 04:11:01,920 --> 04:11:03,440 REVIEW BRANCH AS WELL. 5784 04:11:03,440 --> 04:11:04,880 IT'S JUST REALLY IMPRESSIVE HOW 5785 04:11:04,880 --> 04:11:06,400 MUCH WORK IT IS, AND I 5786 04:11:06,400 --> 04:11:08,400 APPRECIATE ALL OF THAT. 5787 04:11:08,400 --> 04:11:11,120 SO I LOOK FORWARD TO SEEING YOU 5788 04:11:11,120 --> 04:11:12,320 NEXT TIME AND, AGAIN, WE 5789 04:11:12,320 --> 04:11:13,440 PROBABLY MIGHT REACH OUT TO YOU 5790 04:11:13,440 --> 04:11:15,480 IN BETWEEN NOW AND THEN AS WE 5791 04:11:15,480 --> 04:11:17,680 CONTINUE TO THINK ABOUT THESE 5792 04:11:17,680 --> 04:11:18,680 QUESTIONS AND ISSUES. 5793 04:11:18,680 --> 04:11:21,520 BUT I APPRECIATE ALL OF THE 5794 04:11:21,520 --> 04:11:22,000 FEEDBACK. 5795 04:11:22,000 --> 04:11:25,160 IN DUE COURSE AS WE'RE CLOSING 5796 04:11:25,160 --> 04:11:26,920 OUT THIS SESSION, WE WILL GO 5797 04:11:26,920 --> 04:11:28,160 AHEAD AND GAVEL OURSELVES OUT SO 5798 04:11:28,160 --> 04:11:34,480 I'M GOING TO TURN THIS OVER. 5799 04:11:34,480 --> 04:11:37,000 >> THIS MAY BE THE LAST TIME I 5800 04:11:37,000 --> 04:11:40,120 GET TO DO THIS. 5801 04:11:40,120 --> 00:00:00,000 THANKS, EVERYBODY.