1 00:00:10,155 --> 00:00:14,192 >> WELCOME, EVERYONE TO THE 38TH 2 00:00:14,192 --> 00:00:17,095 MEETING OF THE NATIONAL CENTER 3 00:00:17,095 --> 00:00:19,998 FOR ADVISING SCIENCES, ADVISORY 4 00:00:19,998 --> 00:00:21,966 COUNCIL. WELCOME AND OPENING THE 5 00:00:21,966 --> 00:00:23,668 MEETING AND TO DO THAT I NEED TO 6 00:00:23,668 --> 00:00:25,069 GAVEL US IN TO OFFICIALLY START 7 00:00:25,069 --> 00:00:27,939 THE MEETING. I HAVE THIS LITTLE 8 00:00:27,939 --> 00:00:30,175 HANDY DANDY THING HERE. WE 9 00:00:30,175 --> 00:00:32,477 SHALL OPEN THE SESSION. WELCOME 10 00:00:32,477 --> 00:00:34,245 TO THE MEETING, EVERYONE. IT IS 11 00:00:34,245 --> 00:00:37,348 NOT EASY TO DO THAT ALWAYS WHEN 12 00:00:37,348 --> 00:00:39,551 YOU ARE REMOTE SO APOLOGIES FOR 13 00:00:39,551 --> 00:00:43,021 THAT, WE WERE ABLE TO GET IT 14 00:00:43,021 --> 00:00:45,256 DONE. BEFORE WE GET STARTED WITH 15 00:00:45,256 --> 00:00:46,825 THE DIRECTOR'S REPORT I WANT TO 16 00:00:46,825 --> 00:00:50,161 TAKE A MOMENT TO TURN OVER TO 17 00:00:50,161 --> 00:00:53,698 DR. ANNA RAMSEY EWING WHO WILL 18 00:00:53,698 --> 00:00:55,166 DO ROLL CALL FOR THE MEMBERS TO 19 00:00:55,166 --> 00:00:56,734 MAKE SURE WE ARE ACCOUNTED FOR. 20 00:00:56,734 --> 00:00:57,335 ANNA, OVER TO YOU. 21 00:00:57,335 --> 00:01:01,206 >> THANK YOU, JONI. ALL RIGHT. 22 00:01:01,206 --> 00:01:03,174 SERGIO AGUILAR GAXIOLA. ARE YOU 23 00:01:03,174 --> 00:01:05,276 ON? 24 00:01:05,276 --> 00:01:07,111 >> YES, I AM. THANK YOU. 25 00:01:07,111 --> 00:01:09,981 >> THANK YOU. PAUL HARRIS. 26 00:01:09,981 --> 00:01:11,382 >> I'M HERE. 27 00:01:11,382 --> 00:01:17,322 >> THANK YOU. JONATHAN 28 00:01:17,322 --> 00:01:17,622 HIMMELFARB. 29 00:01:17,622 --> 00:01:18,990 >> HERE AS WEL WELL. 30 00:01:18,990 --> 00:01:25,930 >> KELLY MCVEARRY. WE WILL COME 31 00:01:25,930 --> 00:01:29,434 BACK TO KELLY. ROBIN MERMESTEIN. 32 00:01:29,434 --> 00:01:30,935 >> HERE, THANK YOU. 33 00:01:30,935 --> 00:01:33,738 >> KEITH, MUELLER. 34 00:01:33,738 --> 00:01:34,472 >> HERE. 35 00:01:34,472 --> 00:01:36,641 >> AND WHAT ABOUT PAULA 36 00:01:36,641 --> 00:01:46,551 SHIREMAN? ALL RIGHT. KELLY 37 00:01:46,551 --> 00:01:47,919 MCVEARRY, HAVE YOU JOINED? 38 00:01:47,919 --> 00:01:50,588 >> YES. 39 00:01:50,588 --> 00:01:56,561 >> KELLY? I BELIEVE YOU MAY BE 40 00:01:56,561 --> 00:02:07,105 MUTED. I CAN SEE THAT KELLY HAS 41 00:02:07,372 --> 00:02:17,815 JOINED. ALL RIGHT, JONI WILL 42 00:02:21,519 --> 00:02:23,321 IRON OUT THE TECHNICAL GLITCH 43 00:02:23,321 --> 00:02:29,694 WITH KELL KELLY. LET'S GO AHEAD 44 00:02:29,694 --> 00:02:34,933 NEXT SLIDE PLEASE. NEXT SLIDE. 45 00:02:34,933 --> 00:02:36,968 ALL RIGHT. SO WE HAVE HAD OUR 46 00:02:36,968 --> 00:02:40,338 CALL TO ORDER. WE'LL HAVE A FEW 47 00:02:40,338 --> 00:02:42,473 ANNOUNCEMENTS THEN ENJOY OUR 48 00:02:42,473 --> 00:02:43,908 DIRECTOR'S REPORT THAT INCLUDES 49 00:02:43,908 --> 00:02:45,476 THE TRIANGLE INCLUSION REPORT. 50 00:02:45,476 --> 00:02:46,611 AFTER THAT WE HAVE A SHORT 51 00:02:46,611 --> 00:02:48,279 SESSION WHERE WE MAY HAVE SOME 52 00:02:48,279 --> 00:02:49,747 PUBLIC COMMENTS. THEN WE WILL 53 00:02:49,747 --> 00:02:56,421 WRAP UP AND ADJOURN FOR THE DAY 54 00:02:56,421 --> 00:02:58,089 NEXT SLIDE. EVERYONE IN THE MS 55 00:02:58,089 --> 00:03:00,758 TEAMS MEETING IS ATTENDEE. TO 56 00:03:00,758 --> 00:03:02,193 MAINTAIN A SMOOTH FLOW WE 57 00:03:02,193 --> 00:03:03,795 REQUEST YOU WAIT UNTIL THE 58 00:03:03,795 --> 00:03:05,229 PRESENTATION IS OVER THEN USE 59 00:03:05,229 --> 00:03:06,798 THE RAISE HAND FEATURE AND WAIT 60 00:03:06,798 --> 00:03:07,799 UNTIL CALLED UPON TO PROVIDE 61 00:03:07,799 --> 00:03:10,034 INPUT. PLEASE MAKE SURE WHEN 62 00:03:10,034 --> 00:03:12,003 YOU ARE SPEAKING YOUR CAMERA IS 63 00:03:12,003 --> 00:03:13,471 ON SO YOU ARE SPOTLIGHT FORD THE 64 00:03:13,471 --> 00:03:16,007 VIEWERS OF THE VIDEO CAST. IF 65 00:03:16,007 --> 00:03:17,675 YOU ARE NOT ON CAMERA, THE 66 00:03:17,675 --> 00:03:19,677 PREVIOUS SPEAKER WILL REMAIN 67 00:03:19,677 --> 00:03:22,313 SPOTLIGHTED. AUDIENCE MEMBERS 68 00:03:22,313 --> 00:03:24,749 YOU MAY SUBMIT COMMENTS UNTIL 69 00:03:24,749 --> 00:03:26,951 MAY 1 BY USING THE EMAIL 70 00:03:26,951 --> 00:03:29,287 FUNCTION ON NIH VIDEOCAST USING 71 00:03:29,287 --> 00:03:31,189 THE SEND MY FEEDBACK BUTTON OR 72 00:03:31,189 --> 00:03:39,597 BY SENDING AN EMAIL TO 73 00:03:39,597 --> 00:03:44,268 NCATSCOUNCILINPUT@MAIL.NIH.GOV. 74 00:03:44,268 --> 00:03:46,704 AS YOU CAN SEE OUR FEATURE -- I 75 00:03:46,704 --> 00:03:47,438 BELIEVE SOMEONE MAY NEED TO 76 00:03:47,438 --> 00:03:50,375 MUTE. OUR FUTURE MEETING DATES 77 00:03:50,375 --> 00:03:52,377 IS CURRENTLY SCHEDULED. WE DO 78 00:03:52,377 --> 00:03:54,412 NOT KNOW WHEN WE WILL BE HOLDING 79 00:03:54,412 --> 00:03:58,049 THE MAY SESSION, FOR 2525 BUT 80 00:03:58,049 --> 00:03:59,250 ANTICIPATE IT IS LIKELY JUNE OR 81 00:03:59,250 --> 00:04:01,586 JULY. THE SEPTEMBER MEETING IN 82 00:04:01,586 --> 00:04:03,721 2025 IS SCHEDULED FOR SEPTEMBER 83 00:04:03,721 --> 00:04:06,157 18 AND 19TH. IN 2026 THE MEETING 84 00:04:06,157 --> 00:04:08,393 ARE CURRENT WILL I SCHEDULED FOR 85 00:04:08,393 --> 00:04:09,694 JANUARY 29 THROUGH 30TH. THAT 86 00:04:09,694 --> 00:04:13,131 WILL BE A VIRTUAL MEETING. MAY 87 00:04:13,131 --> 00:04:14,799 21-22ND AND SEPTEMBER 17 THROUGH 88 00:04:14,799 --> 00:04:19,270 18TH. NEXT SLIDE. NOW IT IS 89 00:04:19,270 --> 00:04:20,505 TIME FOR OUR REPORT TO COUNCIL 90 00:04:20,505 --> 00:04:23,474 FROM OUR NCATS DIRECTOR. JONI. 91 00:04:23,474 --> 00:04:26,244 >> ALL RIGHT. THANK YOU SO MUCH 92 00:04:26,244 --> 00:04:29,147 ANNA FOR THOSE UPDATES. WELCOME 93 00:04:29,147 --> 00:04:31,282 EVERYONE TO THE REPORT TO THE 94 00:04:31,282 --> 00:04:33,184 COUNCIL FROM ME. I'M EXCITED TO 95 00:04:33,184 --> 00:04:35,687 BE HERE, THIS I BELIEVE IS THE 96 00:04:35,687 --> 00:04:38,256 FIRST COUNCIL OF THE SEASON FOR 97 00:04:38,256 --> 00:04:39,390 SINCE WE HAVE HAD THE NEW 98 00:04:39,390 --> 00:04:40,625 ADMINISTRATION. I WANT TO REMIND 99 00:04:40,625 --> 00:04:45,530 YOU THIS IS NOT THE APRIL MAY 100 00:04:45,530 --> 00:04:47,298 COUNCIL HEARSAY THE JANUARY 101 00:04:47,298 --> 00:04:49,634 COUNCIL WE ARE WORKING ON HERE. 102 00:04:49,634 --> 00:04:51,436 IT JUST HAPPENS TO BE IN APRIL. 103 00:04:51,436 --> 00:04:54,972 WE HAD A FEW DELAYS EARLIER THIS 104 00:04:54,972 --> 00:04:57,108 YEAR IN MOVING FORWARD ON 105 00:04:57,108 --> 00:04:58,142 COUNCIL PRESENTATIONS BUT THIS 106 00:04:58,142 --> 00:05:00,044 IS -- WE ARE RESUMING NOW AND 107 00:05:00,044 --> 00:05:01,713 REALLY EXCITED TO BE HERE TODAY. 108 00:05:01,713 --> 00:05:04,582 SO PLEASE GO TO THE NEXT SLIDE. 109 00:05:04,582 --> 00:05:08,219 WE WILL GET STARTED HERE. IT HAS 110 00:05:08,219 --> 00:05:09,821 BEEN A WHILE SINCE WE MET SO I 111 00:05:09,821 --> 00:05:12,156 WANT TO RECAP WHAT WE HAD TALKED 112 00:05:12,156 --> 00:05:13,591 ABOUT AT OUR LAST COUNCIL WHICH 113 00:05:13,591 --> 00:05:16,027 WAS IN SEPTEMBER OF 2024. AT 114 00:05:16,027 --> 00:05:18,796 THAT POINT IN TIME I TALKED 115 00:05:18,796 --> 00:05:21,332 ABOUT THE NEW LEADERSHIP WE HAD 116 00:05:21,332 --> 00:05:23,701 IN PLACE WITHIN NCATS AND WE ARE 117 00:05:23,701 --> 00:05:27,438 EXCITED TO HAVE THAT LEADERSHIP 118 00:05:27,438 --> 00:05:29,440 IN PLACE AS WE HAVE GONE 119 00:05:29,440 --> 00:05:31,242 FORWARD. AT THE TIME WE DIDN'T 120 00:05:31,242 --> 00:05:33,177 HAVE A 2025 BUDGET WE WERE STILL 121 00:05:33,177 --> 00:05:35,179 MT. MIDST OF CR AND TURNS OUT WE 122 00:05:35,179 --> 00:05:36,981 ARE STILL IN THE MIDST OF A CR, 123 00:05:36,981 --> 00:05:38,916 A FULL YEAR CR IS WHAT OUR 124 00:05:38,916 --> 00:05:41,352 BUDGET LOOKS LIKE. SO THERE 125 00:05:41,352 --> 00:05:42,787 WON'T BE ANY MORE ACTIONS 126 00:05:42,787 --> 00:05:45,022 RELATED TO BUDGET FOR 2025 BUT I 127 00:05:45,022 --> 00:05:47,258 EXPECT WE WILL TALK ABOUT THE 128 00:05:47,258 --> 00:05:49,994 2026 BUDGET IN THE COMING WEEKS 129 00:05:49,994 --> 00:05:52,363 AND MONTHS. I TALKED ABOUT A FEW 130 00:05:52,363 --> 00:05:53,498 CONGRESSIONAL BRIEFINGS, AND I 131 00:05:53,498 --> 00:05:55,933 WILL TALK ADDITIONAL ONES DONE 132 00:05:55,933 --> 00:05:58,269 SINCE THEN. ALSO AT THE LAST 133 00:05:58,269 --> 00:05:59,937 COUNCIL IT WAS KIND OF A NICE 134 00:05:59,937 --> 00:06:02,607 MOMENT BECAUSE IT WAS UNUSUAL 135 00:06:02,607 --> 00:06:05,977 WHEN THE COUNCIL WROTE A LETTER 136 00:06:05,977 --> 00:06:07,445 TO ME AND BECAUSE ANY LETTER 137 00:06:07,445 --> 00:06:08,880 THAT IS WRITTEN TO ME OR TO THE 138 00:06:08,880 --> 00:06:10,581 COUNCIL I NEED TO MAKE PUBLIC SO 139 00:06:10,581 --> 00:06:13,851 I BRING THOSE UP IN OPEN 140 00:06:13,851 --> 00:06:16,621 COUNCIL. IT WAS A MOMENT WHERE I 141 00:06:16,621 --> 00:06:18,723 WAS ABLE TO TALK ABOUT LETTER 142 00:06:18,723 --> 00:06:22,927 FROM OUR COUNCIL TO ME ABOUT HOW 143 00:06:22,927 --> 00:06:24,495 THEY'RE ENTHUSIASTIC ABOUT 144 00:06:24,495 --> 00:06:27,064 CHANGING NCATS FROM CENTER TO AN 145 00:06:27,064 --> 00:06:29,066 INSTITUTE. I HOPE TO UPDATE YOU 146 00:06:29,066 --> 00:06:31,302 A LITTLE BIT ON WHAT HAS 147 00:06:31,302 --> 00:06:33,404 TRANSPIRED SINCE THEN BUT I 148 00:06:33,404 --> 00:06:36,073 WANTED TO AGAIN THANK OUR 149 00:06:36,073 --> 00:06:37,975 COUNCIL FOR THE CO-ACTIVE NATURE 150 00:06:37,975 --> 00:06:39,544 AND BEING INVOLVED IN HELPING 151 00:06:39,544 --> 00:06:41,445 ADVANCE TRANSLATIONAL SCIENCES. 152 00:06:41,445 --> 00:06:43,281 SO I'M GOING TO GO AHEAD AND 153 00:06:43,281 --> 00:06:44,415 MOVE FORWARD ON SOME OF THE 154 00:06:44,415 --> 00:06:46,517 OTHER ADVANCES WE HAVE HAD OVER 155 00:06:46,517 --> 00:06:48,419 THE PAST YEAR. SO MOVING TO THE 156 00:06:48,419 --> 00:06:50,087 NEXT SLIDE. BEFORE I GET INTO 157 00:06:50,087 --> 00:06:51,422 THE SCIENTIFIC ADVANCES I WANT 158 00:06:51,422 --> 00:06:54,959 TALK ABOUT SOME OF THESE NEWS 159 00:06:54,959 --> 00:06:56,527 ANNOUNCEMENT CHANGES THAT HAVE 160 00:06:56,527 --> 00:06:58,996 BEEN TAKING PLACE. AS Y'ALL KNOW 161 00:06:58,996 --> 00:07:00,865 PLEASE GO TO THE NEXT SLIDE, 162 00:07:00,865 --> 00:07:02,800 WITH ANY NEW ADMINISTRATION 163 00:07:02,800 --> 00:07:06,804 COMES NEW LEADERSHIP. AS NIH IS 164 00:07:06,804 --> 00:07:08,506 IN THE DEPARTMENT OF HEALTH AND 165 00:07:08,506 --> 00:07:11,275 HUMAN SERVICES OUR DHHS, ROBERT 166 00:07:11,275 --> 00:07:13,744 F. KENNEDY JR. WAS SWORN IN AS 167 00:07:13,744 --> 00:07:16,747 SECRETARY OF DHHS BACK IN 168 00:07:16,747 --> 00:07:19,784 FEBRUARY. AND HE HAS ARTICULATED 169 00:07:19,784 --> 00:07:21,018 HIS VISION FOR THE HEALTH OF THE 170 00:07:21,018 --> 00:07:22,820 AMERICAN PEOPLE. SO HE'S IN 171 00:07:22,820 --> 00:07:25,022 PLACE AND THAT ALLOWED US TO GO 172 00:07:25,022 --> 00:07:29,126 TO THE NEXT SLIDE AND BRING ON A 173 00:07:29,126 --> 00:07:30,795 NEW NIH DIRECTOR SO FOLLOWING 174 00:07:30,795 --> 00:07:32,263 THE APPOINTMENT OF THE SECRETARY 175 00:07:32,263 --> 00:07:34,832 WE WERE PLEASED TO WELCOME DR. 176 00:07:34,832 --> 00:07:36,300 JAY BHATTACHARYA. HE IS AN 177 00:07:36,300 --> 00:07:38,636 ACCOMPLISHED DOCTOR RESEARCHER 178 00:07:38,636 --> 00:07:40,872 AND HEALTH ECONOMIST. HE HELD A 179 00:07:40,872 --> 00:07:43,207 TENURE PROFESSORSHIP IN MEDICAL 180 00:07:43,207 --> 00:07:44,775 SCHOOL AT STANFORD UNIVERSITY IN 181 00:07:44,775 --> 00:07:46,677 CALIFORNIA AND DR. BHATTACHARYA 182 00:07:46,677 --> 00:07:49,013 RESEARCH HAS FOCUSED ON 183 00:07:49,013 --> 00:07:51,549 POPULATION AGING AND CHRONIC 184 00:07:51,549 --> 00:07:53,084 DISEASE PARTICULARLY IN HEALTH 185 00:07:53,084 --> 00:07:54,852 AND WELL BEING OF VULNERABLE 186 00:07:54,852 --> 00:07:57,121 POPULATIONS. HE EXPECTS TO 187 00:07:57,121 --> 00:07:58,356 CONTINUE SOME OF THOSE 188 00:07:58,356 --> 00:07:59,690 ACTIVITIES ON THE BROADER SCALE 189 00:07:59,690 --> 00:08:02,693 AT THE NIH AND I WILL TALK MORE 190 00:08:02,693 --> 00:08:06,664 ABOUT HIS BROADER VISION. HE IS 191 00:08:06,664 --> 00:08:08,199 ENCOURAGING DIFFERENT 192 00:08:08,199 --> 00:08:09,033 PERSPECTIVES BECAUSE THAT WILL 193 00:08:09,033 --> 00:08:12,203 BE CENTRAL TO HIS APPROACH IN 194 00:08:12,203 --> 00:08:14,772 LEADING THE NIH, LEANING ON THE 195 00:08:14,772 --> 00:08:17,241 NIH EXPERTISE AND INNOVATION AND 196 00:08:17,241 --> 00:08:20,111 THE PURSUIT OF SCIENCE. SO WE 197 00:08:20,111 --> 00:08:21,479 LOOK FORWARD TO HIS LEADERSHIP 198 00:08:21,479 --> 00:08:24,582 AND ENSURING THE NIH FULFILLS 199 00:08:24,582 --> 00:08:25,917 ITS MISSION TO HAVE ADVANCING 200 00:08:25,917 --> 00:08:28,219 HEALTH AND LENGTHENING LIFE 201 00:08:28,219 --> 00:08:29,053 THROUGH EXCELLENT BIOMEDICAL 202 00:08:29,053 --> 00:08:30,955 RESEARCH. HE JOINED A FEW WEEKS 203 00:08:30,955 --> 00:08:33,925 AGO IN THE MIDST OF QUITE SOME 204 00:08:33,925 --> 00:08:36,027 DRAMATIC CHANGES THAT ARE STILL 205 00:08:36,027 --> 00:08:39,096 IMPACTING THE NIH. AND I HAVE 206 00:08:39,096 --> 00:08:40,765 HAD THE OPPORTUNITY TO MEET WITH 207 00:08:40,765 --> 00:08:42,667 HIM AND TALK ABOUT NCATS AND I 208 00:08:42,667 --> 00:08:44,869 HAVE REALLY BEEN IMPRESSED BY 209 00:08:44,869 --> 00:08:46,203 HIS SCIENTIFIC CURIOSITY AND 210 00:08:46,203 --> 00:08:49,640 DRIVE TO USE THAT FOR IMPACTING 211 00:08:49,640 --> 00:08:51,909 OUR ABILITY TO ADVANCE OUR 212 00:08:51,909 --> 00:08:53,678 UNDERSTANDING OF DISEASE. HE IS 213 00:08:53,678 --> 00:08:55,246 PUBLICLY SPOKEN ABOUT HIS TOP 214 00:08:55,246 --> 00:08:58,115 THREE AREAS AND SO THAT HE'S 215 00:08:58,115 --> 00:08:59,917 MOST INTERESTED THAT HE WANTS TO 216 00:08:59,917 --> 00:09:01,285 PUSH. SO I WANT TO TALK ABOUT 217 00:09:01,285 --> 00:09:02,920 THOSE FOR JUST A SECOND. IF HE 218 00:09:02,920 --> 00:09:05,056 CAN GO TO NEXT SLIDE. THESE ARE 219 00:09:05,056 --> 00:09:10,027 HIS TOP THREE AREAS OF INTEREST 220 00:09:10,027 --> 00:09:11,495 AND THERE ARE THREE MAIN ONES. 221 00:09:11,495 --> 00:09:13,931 HE TALKS A LITTLE BIT IN MORE 222 00:09:13,931 --> 00:09:15,866 DETAIL BUT I WILL JUST DESCRIBE 223 00:09:15,866 --> 00:09:17,134 THESE AT A HIGH LEVEL. THE FIRST 224 00:09:17,134 --> 00:09:19,937 IS TO FOCUS ON DISEASES AND 225 00:09:19,937 --> 00:09:21,172 CONDITIONS THAT AFFECT PEOPLE. 226 00:09:21,172 --> 00:09:22,740 THESE ARE CHRONIC BUT HE IS 227 00:09:22,740 --> 00:09:24,208 CLEAR TO POINT OUT RARE DISEASE 228 00:09:24,208 --> 00:09:25,443 AND UNDERSTANDING RARE DISEASE 229 00:09:25,443 --> 00:09:27,378 IS IMPORTANT IN THAT 230 00:09:27,378 --> 00:09:28,813 UNDERSTANDING. SO BOTH CHRONIC 231 00:09:28,813 --> 00:09:31,615 AND RARE DISEASE ARE IMPORTANT. 232 00:09:31,615 --> 00:09:32,950 DAY OF REPRODUCIBILITY AND 233 00:09:32,950 --> 00:09:35,953 DRIVING INNOVATION. AND THE WAY 234 00:09:35,953 --> 00:09:37,188 HE THINKS ABOUT THIS TOO IS THIS 235 00:09:37,188 --> 00:09:38,889 IS ABOUT THESE AREAS AT THE 236 00:09:38,889 --> 00:09:40,458 BASIC LEVEL, AT THE 237 00:09:40,458 --> 00:09:41,292 TRANSLATIONAL LEVEL AND THE 238 00:09:41,292 --> 00:09:45,463 CLINICAL LEVEL. SO IN TERMS OF 239 00:09:45,463 --> 00:09:47,932 HOW NCATS IS WELL-POSITIONED IN 240 00:09:47,932 --> 00:09:52,103 EACH OF THESE AREAS, FOR EXAMPLE 241 00:09:52,103 --> 00:09:55,239 IN THE FIRST GOAL NCATS HAS TWO 242 00:09:55,239 --> 00:09:56,707 FLAGSHIP PROGRAMS MADE REALLY 243 00:09:56,707 --> 00:09:58,609 FOR STUDYING CHRONIC AND RARE 244 00:09:58,609 --> 00:10:01,245 DISEASE. THE CTSAs AND RARE 245 00:10:01,245 --> 00:10:03,014 DISEASE CLINICAL RESEARCH 246 00:10:03,014 --> 00:10:04,348 NETWORK AND OTHER PROGRAMS LIKE 247 00:10:04,348 --> 00:10:07,785 DATA TRANSLATOR AND 3C, AND OUR 248 00:10:07,785 --> 00:10:11,088 DATA RESOURCES, STUDYING THESE 249 00:10:11,088 --> 00:10:12,456 UNDERDOG PROTEINS THAT ARE SEEN 250 00:10:12,456 --> 00:10:14,759 AS HIGH RISK BUT HAVE HIGH 251 00:10:14,759 --> 00:10:16,427 POTENTIAL FOR SMALL MOLECULE 252 00:10:16,427 --> 00:10:18,362 DEVELOPMENT, THESE ARE ALL AREAS 253 00:10:18,362 --> 00:10:19,797 NCATS IS WORKING TOWARDS, WE ARE 254 00:10:19,797 --> 00:10:21,899 ALSO WORKING TOWARDS DEVELOPING 255 00:10:21,899 --> 00:10:23,367 A NEW MODEL THAT ARE MORE HUMAN 256 00:10:23,367 --> 00:10:27,738 FIZZ Q2 LOGICALLY BASED TO HELP 257 00:10:27,738 --> 00:10:30,775 US -- PHYSIOLOGICALLY BASED TO 258 00:10:30,775 --> 00:10:32,910 HELP STUDY DISEASES. SO IN MANY 259 00:10:32,910 --> 00:10:34,111 WAYS WELL-POSITIONED TO 260 00:10:34,111 --> 00:10:35,246 CONTRIBUTE TO THIS PARTICULAR 261 00:10:35,246 --> 00:10:36,714 GOAL. WE ARE ALSO 262 00:10:36,714 --> 00:10:37,415 WELL-POSITIONED TO CONTRIBUTE TO 263 00:10:37,415 --> 00:10:39,383 THE OTHERS. IN TERMS OF 264 00:10:39,383 --> 00:10:40,851 REPRODUCIBILITY, THIS IS A WORD 265 00:10:40,851 --> 00:10:43,054 THAT IS WOVEN INTO OUR FABRIC AT 266 00:10:43,054 --> 00:10:45,289 NCATS. MANY OF OUR PROGRAMS 267 00:10:45,289 --> 00:10:48,726 REQUIRE INDEPENDENT VALIDATION 268 00:10:48,726 --> 00:10:50,828 AS PART OF THE AWARD WE SUPPORT, 269 00:10:50,828 --> 00:10:52,296 PART OF THE AWARDS WE SUPPORT. 270 00:10:52,296 --> 00:10:54,298 AND FOR EXAMPLE, OUR GENE TARGET 271 00:10:54,298 --> 00:10:56,834 THERAPY WORK AS WELL AS TISSUE 272 00:10:56,834 --> 00:10:58,402 CHIP PROGRAM, THESE EFFORTS ARE 273 00:10:58,402 --> 00:11:00,304 ONES THAT HAVE VALIDATION 274 00:11:00,304 --> 00:11:02,840 NETWORKS BUILT IN TO THE FABRIC 275 00:11:02,840 --> 00:11:04,708 OF THESE PROGRAMS. OTHER THINGS 276 00:11:04,708 --> 00:11:06,710 LIKE TESTING CENTERS FOR 277 00:11:06,710 --> 00:11:09,580 QUALIFICATION ARE IMPORTANT FOR 278 00:11:09,580 --> 00:11:10,915 NOVEL APPROACH METHODOLOGIES. SO 279 00:11:10,915 --> 00:11:12,583 THESE ARE REALLY IMPORTANT. IN 280 00:11:12,583 --> 00:11:14,518 ADDITION OUR NCATS LABS HAVE 281 00:11:14,518 --> 00:11:16,921 SPEARHEADED SOMETHING CALLED 282 00:11:16,921 --> 00:11:19,256 TRANSLATION TOGETHER WITH 283 00:11:19,256 --> 00:11:20,825 REPRODUCIBILITY AS ONE AREA OF A 284 00:11:20,825 --> 00:11:23,661 KEY EMPHASIS. TRANSLATION 285 00:11:23,661 --> 00:11:26,564 TOGETHER IS A PROGRAM THAT WORKS 286 00:11:26,564 --> 00:11:27,465 ACROSS 7 DIFFERENT COUNTRIES TO 287 00:11:27,465 --> 00:11:29,900 TEST AND VALIDATE ASSAYS IN MANY 288 00:11:29,900 --> 00:11:31,669 DIFFERENT LABS TO UNDERSTAND AND 289 00:11:31,669 --> 00:11:32,703 WORK THROUGH THE DIFFERENCES 290 00:11:32,703 --> 00:11:35,306 THAT WE SEE AS THOSE ASSAYS ARE 291 00:11:35,306 --> 00:11:36,607 CONDUCTED IN DIFFERENT 292 00:11:36,607 --> 00:11:38,709 LABORATORY ENVIRONMENTS. TO 293 00:11:38,709 --> 00:11:39,510 UNDERSTAND WHERE VARIABILITY 294 00:11:39,510 --> 00:11:41,412 COMES IN, UNDERSTAND HOW THAT 295 00:11:41,412 --> 00:11:42,446 IMPACTS DATA REPRODUCIBILITY. SO 296 00:11:42,446 --> 00:11:45,382 THIS IS AN IMPORTANT PROGRAM WE 297 00:11:45,382 --> 00:11:49,186 HAVE BEEN PART OF AND LOOK TO 298 00:11:49,186 --> 00:11:51,088 CONTINUE THAT WORK. IN ADDITION 299 00:11:51,088 --> 00:11:53,190 NCATS OVERSEES THE ASSAY 300 00:11:53,190 --> 00:11:56,494 GUIDANCE MANUAL. THIS IS A 301 00:11:56,494 --> 00:11:58,596 PROGRAM THAT DOES WORKSHOPS, 302 00:11:58,596 --> 00:12:01,365 WEBINARS, AND ACTUALLY HAS AN 303 00:12:01,365 --> 00:12:03,134 ACTUAL MANUAL CALLED THE ASSAY 304 00:12:03,134 --> 00:12:05,002 GUIDANCE MANUAL. THESE 305 00:12:05,002 --> 00:12:06,604 DISSEMINATE BEST LABORATORY 306 00:12:06,604 --> 00:12:08,172 PRACTICES. THEY DEVELOP TOOLS 307 00:12:08,172 --> 00:12:12,676 FOR DATA ANALYSIS AND RIGOR AN 308 00:12:12,676 --> 00:12:13,711 REPRODUCIBILITY AND PRE-CLINICAL 309 00:12:13,711 --> 00:12:14,945 DRUG DISCOVERY. I WILL TALK 310 00:12:14,945 --> 00:12:16,180 ABOUT ONE OF THE WORKSHOPS HELD 311 00:12:16,180 --> 00:12:18,349 IN A MOMENT BUT I WANTED TO GIVE 312 00:12:18,349 --> 00:12:20,351 YOU A SENSE THAT THIS 313 00:12:20,351 --> 00:12:22,853 REPRODUCIBILITY COMPONENT IS KEY 314 00:12:22,853 --> 00:12:26,390 FOR US AND NCATS BECAUSE IT IS 315 00:12:26,390 --> 00:12:28,492 SO CRITICAL HOW WE DRIVE THE 316 00:12:28,492 --> 00:12:29,226 TRANSLATIONAL CLINICAL SCIENCE 317 00:12:29,226 --> 00:12:32,429 THAT FOLLOWS. THE LAST ONE 318 00:12:32,429 --> 00:12:34,532 HERE, BUT NOT LEAST IS CERTAINLY 319 00:12:34,532 --> 00:12:37,067 AROUND INNOVATION. HERE AGAIN 320 00:12:37,067 --> 00:12:38,903 INNOVATION IS A WORD INHERENT IN 321 00:12:38,903 --> 00:12:41,438 WHAT WE DO AT NCATS. TEAM 322 00:12:41,438 --> 00:12:43,107 SCIENCE DRIVES INNOVATION AND 323 00:12:43,107 --> 00:12:45,643 THIS IS A NATURAL FOR US. OUR 324 00:12:45,643 --> 00:12:47,678 DIVISION OF CLINICAL INNOVATION, 325 00:12:47,678 --> 00:12:50,247 THAT IS EVEN BUILT TO THE NAMES 326 00:12:50,247 --> 00:12:52,249 OF ALL OUR DIVISIONS, THE 327 00:12:52,249 --> 00:12:53,250 CTSAs ARE WITHIN THAT 328 00:12:53,250 --> 00:12:54,752 DIVISION. THEY INNOVATE ON MANY 329 00:12:54,752 --> 00:12:57,555 THINGS THAT ARE CLINICALLY 330 00:12:57,555 --> 00:13:00,824 RELEVANT. INCLUDING HAVING 331 00:13:00,824 --> 00:13:02,126 CLINICAL TRIAL NETWORK AND 332 00:13:02,126 --> 00:13:03,694 SPEARHEADING NATIONAL CLINICAL 333 00:13:03,694 --> 00:13:06,297 COHORT COLLABORATIVE OR NC 3 334 00:13:06,297 --> 00:13:08,899 CLINICAL WHICH IS AN ENCLAVE OF 335 00:13:08,899 --> 00:13:10,334 ELECTRONIC HEALTH RECORDS AND 336 00:13:10,334 --> 00:13:11,569 REAL WORLD DATA. OUR DIVISION OF 337 00:13:11,569 --> 00:13:15,406 THE RARE DISEASE RESEARCH 338 00:13:15,406 --> 00:13:17,741 INNOVATION, THAT WORK AGAIN, IT 339 00:13:17,741 --> 00:13:19,777 PROVIDED LEADERSHIP TO INNOVATE 340 00:13:19,777 --> 00:13:22,413 RARE DISEASE AND INCLUDING 341 00:13:22,413 --> 00:13:23,681 CLINICAL TRIALS, BIOMARKER 342 00:13:23,681 --> 00:13:25,549 DEVELOPMENT. THIS IS THE 343 00:13:25,549 --> 00:13:26,584 CRITICAL BECAUSE NUMBER OF 344 00:13:26,584 --> 00:13:27,718 PATIENTS WITH A GIVEN RARE 345 00:13:27,718 --> 00:13:30,354 DISEASE ARE SMALL, RARE. AND SO 346 00:13:30,354 --> 00:13:34,091 INNOVATING ON HOW TO STUDY 347 00:13:34,091 --> 00:13:37,895 CLINICAL TRIALS AN RESEARCH IN 348 00:13:37,895 --> 00:13:39,763 SMALL POPULATION, IS A CHALLENGE 349 00:13:39,763 --> 00:13:41,665 SO WE APPROACH RARE DISEASE IN 350 00:13:41,665 --> 00:13:43,867 MORE THAN ONE DISEASE AT A TIME 351 00:13:43,867 --> 00:13:46,437 MANNER TO THINK REALLY IN WAYS 352 00:13:46,437 --> 00:13:48,772 THAT ARE SYSTEMS GENERATING. 353 00:13:48,772 --> 00:13:50,407 BIOLOGICAL SYSTEMS GENERATED. 354 00:13:50,407 --> 00:13:52,409 BUILDING PLATFORM BASED 355 00:13:52,409 --> 00:13:53,978 APPROACHES FOR PRECISION 356 00:13:53,978 --> 00:13:57,081 MEDICINE ESPECIALLY GENE TARGET 357 00:13:57,081 --> 00:13:58,082 THERAPIES, ET CETERA. FINALLY 358 00:13:58,082 --> 00:14:00,851 OUR DIVISION OF PRE-CLINICAL 359 00:14:00,851 --> 00:14:02,653 INNOVATION, THIS IS -- THESE ARE 360 00:14:02,653 --> 00:14:06,523 NCATS LABS AND IT IS TEAMING AN 361 00:14:06,523 --> 00:14:08,993 ENVIRONMENT OF INNOVATION. IT IS 362 00:14:08,993 --> 00:14:10,127 VERY SUCCESSFUL IN CONTRIBUTING 363 00:14:10,127 --> 00:14:13,530 TO NEW DRUG APPROVALS, USING 364 00:14:13,530 --> 00:14:14,898 DATA SCIENCE, LEADING IN AREAS 365 00:14:14,898 --> 00:14:17,868 SUCH AS AI, FOR DRUG 366 00:14:17,868 --> 00:14:18,769 DEVELOPMENT, HIGH THROUGH PUT 367 00:14:18,769 --> 00:14:21,438 SCREENING AND ASSAY DEVELOPMENT 368 00:14:21,438 --> 00:14:23,440 ARE ALL CRITICAL THINGS THAT 369 00:14:23,440 --> 00:14:24,975 DRIVE RESULTS THAT REDUCE 370 00:14:24,975 --> 00:14:26,744 BARRIERS IN TRANSLATIONAL 371 00:14:26,744 --> 00:14:27,778 SCIENCE SO WE CAN PIVOT TO ANY 372 00:14:27,778 --> 00:14:31,649 DISEASE OR PROJECT THAT IS 373 00:14:31,649 --> 00:14:37,321 NEEDED FOR US TO HELP OUT AND 374 00:14:37,321 --> 00:14:38,889 MOVE FORWARD IN. SO NCATS IS 375 00:14:38,889 --> 00:14:40,491 REALLY GROUNDED IN EACH OF THESE 376 00:14:40,491 --> 00:14:42,459 AREAS AND WE ARE EXCITED TO WORK 377 00:14:42,459 --> 00:14:45,362 WITH DR. BHATTACHARYA IN MOVING 378 00:14:45,362 --> 00:14:46,463 THIS VISION FORWARD AND 379 00:14:46,463 --> 00:14:47,564 CONTINUING REALLY THE WORK WE 380 00:14:47,564 --> 00:14:50,701 HAVE BEEN DOING FOR A WHILE, 381 00:14:50,701 --> 00:14:52,903 PERHAPS ADDING TO THAT IN MORE 382 00:14:52,903 --> 00:14:54,605 INNOVATIVE CREATIVE WAYS. ON 383 00:14:54,605 --> 00:15:00,144 THE NEXT SLIDE, I WILL SAY TOO 384 00:15:00,144 --> 00:15:01,845 AS WE HAVE NEW LEADERSHIP COMING 385 00:15:01,845 --> 00:15:03,647 IN WE HAVE ALSO BEEN IN THE 386 00:15:03,647 --> 00:15:06,517 MIDST OF ALIGNING WITH HHS AND 387 00:15:06,517 --> 00:15:08,619 NIH PRIORITIES THAT HAVE BEEN 388 00:15:08,619 --> 00:15:10,554 SET FORTH WITHIN THE TRANSITION 389 00:15:10,554 --> 00:15:12,523 OF THE NEW ADMINISTRATION. SO 390 00:15:12,523 --> 00:15:15,092 THERE'S LOTS OF CHANGES BEING 391 00:15:15,092 --> 00:15:16,527 MADE, AT GOVERNMENT LEVEL, AS 392 00:15:16,527 --> 00:15:18,362 WELL AS AT THE NIH LEVEL. MANY 393 00:15:18,362 --> 00:15:20,597 OF THESE CHANGES ARE STILL 394 00:15:20,597 --> 00:15:22,866 UNDERWAY AS WE WORK TO IMPLEMENT 395 00:15:22,866 --> 00:15:28,372 THEM AND WITH THAT I WOULD SAY 396 00:15:28,372 --> 00:15:30,307 WE MAY NOT KNOW THE ANSWERS YET 397 00:15:30,307 --> 00:15:32,343 TO HOW WE WILL MOVE FORWARD ON 398 00:15:32,343 --> 00:15:34,278 ALL ASPECTS BUT WE DO HAVE -- WE 399 00:15:34,278 --> 00:15:36,347 ARE STARTING TO GET MORE CLARITY 400 00:15:36,347 --> 00:15:39,249 IN TERMS OF THINGS LIKE SOME OF 401 00:15:39,249 --> 00:15:42,319 THESE FEATURES THAT THESE 402 00:15:42,319 --> 00:15:44,355 CHANGES HAVE CONTRIBUTED TO. FOR 403 00:15:44,355 --> 00:15:46,824 EXAMPLE WE ARE CENTRALIZING OUR 404 00:15:46,824 --> 00:15:48,459 PEER REVIEW PROCESS AT THE NIH. 405 00:15:48,459 --> 00:15:49,493 ONE OF THE REASONS WE ARE DOING 406 00:15:49,493 --> 00:15:53,397 THAT IS SO WE CAN STRENGTHEN OUR 407 00:15:53,397 --> 00:15:54,665 CONFLICT OF INTEREST SAFEGUARDS 408 00:15:54,665 --> 00:15:59,069 THERE'S BEEN A PERCEPTION THAT 409 00:15:59,069 --> 00:16:00,371 HAVING THE APPLICATIONS THAT 410 00:16:00,371 --> 00:16:03,040 COME INTO AN IC AND HAVING IC 411 00:16:03,040 --> 00:16:05,609 REVIEW THEM MIGHT CREATE SOME 412 00:16:05,609 --> 00:16:07,344 CONFLICT. REST ASSURED WE HAVE 413 00:16:07,344 --> 00:16:09,012 MANAGED THAT CONFLICT VERY WELL. 414 00:16:09,012 --> 00:16:12,116 AND ARE VERY CAREFUL ABOUT THAT 415 00:16:12,116 --> 00:16:15,552 HOWEVER THERE IS A PERCEPTION. 416 00:16:15,552 --> 00:16:16,887 CENTRALIZING PEER REVIEW IS A 417 00:16:16,887 --> 00:16:18,989 REASONABLE RESPONSE TO THAT AND 418 00:16:18,989 --> 00:16:21,525 THAT IS ONE WAY WE ARE GOING TO 419 00:16:21,525 --> 00:16:25,329 -- SYSTEM OF THESE CHANGES ARE 420 00:16:25,329 --> 00:16:29,166 AFFECTING THE ALIGNMENT TO THESE 421 00:16:29,166 --> 00:16:31,068 PRIORITIES. I WILL SAY TOO IT IS 422 00:16:31,068 --> 00:16:33,971 IMPORTANT FOR US TO CONSIDER 423 00:16:33,971 --> 00:16:36,273 THAT, A LOT OF THESE CHANGES ARE 424 00:16:36,273 --> 00:16:37,708 CREATING WAYS WE MIGHT DO 425 00:16:37,708 --> 00:16:39,209 BUSINESS DIFFERENTLY BUT I'M 426 00:16:39,209 --> 00:16:40,644 HOPING IT WILL BE A SEAMLESS 427 00:16:40,644 --> 00:16:42,246 TRANSITION FOR THE COMMUNITIES 428 00:16:42,246 --> 00:16:43,247 PERSPECTIVE IN TERMS OF THAT 429 00:16:43,247 --> 00:16:46,350 PEER REVIEW EXPERIENCE. BECAUSE 430 00:16:46,350 --> 00:16:48,719 IN MANY WAYS A LOT OF STAFF THAT 431 00:16:48,719 --> 00:16:49,720 WILL BE CONDUCTING THAT PEER 432 00:16:49,720 --> 00:16:52,055 REVIEW WHO HAVE BEEN IN ICs 433 00:16:52,055 --> 00:16:54,291 BEFORE WILL BE TRANSITIONING TO 434 00:16:54,291 --> 00:16:55,859 THEIR MORE CENTRALIZED ROLE 435 00:16:55,859 --> 00:16:58,495 WITHIN CSR TO CONTINUE 436 00:16:58,495 --> 00:17:01,832 CONDUCTING THOSE REVIEWS. AGAIN, 437 00:17:01,832 --> 00:17:02,466 THE IDEA WOULD BE THAT THIS 438 00:17:02,466 --> 00:17:04,101 WOULD BE A SEAMLESS TRANSITION 439 00:17:04,101 --> 00:17:07,438 AND I THINK THAT'S -- THAT WILL 440 00:17:07,438 --> 00:17:15,379 HOPEFULLY WORK VERY WELL. OTHER 441 00:17:15,379 --> 00:17:16,180 CHANGES THAT YOU HAVE 442 00:17:16,180 --> 00:17:17,981 EXPERIENCED IS WE HAVE HAD A 443 00:17:17,981 --> 00:17:20,551 PAUSE ON FACA MEETINGS. REVIEW 444 00:17:20,551 --> 00:17:22,953 AND COUNSEL MEETINGS BUT AS 445 00:17:22,953 --> 00:17:24,321 EVIDENCE TODAY WE ARE HAVING THE 446 00:17:24,321 --> 00:17:25,756 FIRST COUNCIL MEETING OF THE 447 00:17:25,756 --> 00:17:29,059 SEASON AND SO THESE FACA 448 00:17:29,059 --> 00:17:30,394 MEETINGS ARE RESUMING NOW. IN 449 00:17:30,394 --> 00:17:31,995 FACT OVER THE PAST COUPLE OF 450 00:17:31,995 --> 00:17:34,631 WEEKS WE HAVE SEEN MORE REVIEW 451 00:17:34,631 --> 00:17:36,767 MEETINGS HAPPEN IN CSR SO THINGS 452 00:17:36,767 --> 00:17:37,801 ARE STARTING TO RESUME AND THAT 453 00:17:37,801 --> 00:17:41,572 IS REALLY A GOOD THING. ONE 454 00:17:41,572 --> 00:17:43,474 THING YOU PROBABLY NOTICED IN 455 00:17:43,474 --> 00:17:46,343 YOUR WORDS OR IN PARTICULAR 456 00:17:46,343 --> 00:17:47,144 FUNDING OPPORTUNITIES THERE HAVE 457 00:17:47,144 --> 00:17:50,347 BEEN CHANGES TO HOW WE LOOK AT 458 00:17:50,347 --> 00:17:53,684 AWARDS AND MAKING SURE WE ARE 459 00:17:53,684 --> 00:17:57,888 ALIGNING WITH THE HHS AND NIH 460 00:17:57,888 --> 00:17:59,156 PRIORITIES WITHIN THOSE AWARDS. 461 00:17:59,156 --> 00:18:01,258 SO THERE MAY BE CHANGES IN 462 00:18:01,258 --> 00:18:04,561 COMPETING APPLICATIONS OR 463 00:18:04,561 --> 00:18:06,029 NON-COMPETING RENEWALS THAT YOU 464 00:18:06,029 --> 00:18:07,297 MAY EXPERIENCE. THAT IS ALL JUST 465 00:18:07,297 --> 00:18:11,502 TO MAKE SURE WE ARE ALIGNING 466 00:18:11,502 --> 00:18:13,837 WITH HHS AND NIH PRIORITIES. YOU 467 00:18:13,837 --> 00:18:15,939 WILL ALSO SEE IF YOU LOOK AT A 468 00:18:15,939 --> 00:18:18,842 PARTICULAR NOTICE OF FUNDING 469 00:18:18,842 --> 00:18:20,177 OPPORTUNITY, ALL OF THESE HAVE 470 00:18:20,177 --> 00:18:22,846 ALSO BEEN ADJUSTED TO REFLECT 471 00:18:22,846 --> 00:18:26,950 THE HHS AND NIH PRIORITIES. SO 472 00:18:26,950 --> 00:18:27,951 THEY HAVE BEEN ESSENTIALLY 473 00:18:27,951 --> 00:18:31,388 REVISED WHERE THEY NEEDED TO BE 474 00:18:31,388 --> 00:18:33,590 REVISED AND REPOSTED SO ALL 475 00:18:33,590 --> 00:18:35,926 NCATS NOFOs HAVE GONE LIEU 476 00:18:35,926 --> 00:18:37,127 THIS PROCESS. SO EVERYTHING 477 00:18:37,127 --> 00:18:39,196 SHOULD BE UP TO DATE THERE. I 478 00:18:39,196 --> 00:18:40,797 WANT TO JUST STOP HERE AND JUST 479 00:18:40,797 --> 00:18:42,766 SAY A FEW OTHER THINGS TO 480 00:18:42,766 --> 00:18:44,234 HIGHLIGHT UNDER THE AWARDS 481 00:18:44,234 --> 00:18:45,903 CATEGORY. IN TERMS OF THE 482 00:18:45,903 --> 00:18:48,572 APPLICATIONS AND CERTAINLY FOR 483 00:18:48,572 --> 00:18:51,041 FOLKS WHO ARE LISTENING IN, 484 00:18:51,041 --> 00:18:52,409 ACCEPTING APPLICATIONS FOR 485 00:18:52,409 --> 00:18:55,212 ACTIVE FUNDING OPPORTUNITIES, 486 00:18:55,212 --> 00:18:56,480 SOME OF THOSE OPPORTUNITIES MAY 487 00:18:56,480 --> 00:18:58,482 HAVE BEEN CLOSED DEPENDING ON 488 00:18:58,482 --> 00:18:59,650 WHAT THEY WERE -- WHAT THEY WERE 489 00:18:59,650 --> 00:19:02,085 FOCUSING ON AND OTHERS AS I 490 00:19:02,085 --> 00:19:03,487 MENTIONED HAVE BEEN UPDATED TO 491 00:19:03,487 --> 00:19:05,956 ALIGN WITH THESE AGENCY 492 00:19:05,956 --> 00:19:08,058 PRIORITIES. SO I REALLY WANT TO 493 00:19:08,058 --> 00:19:10,961 MAKE SURE APPLICANTS OUT THERE 494 00:19:10,961 --> 00:19:13,430 ARE CONSIDERING THESE CHANGES 495 00:19:13,430 --> 00:19:15,399 CAREFULLY REREADING AND 496 00:19:15,399 --> 00:19:16,300 REVIEWING THOSE FUNDING 497 00:19:16,300 --> 00:19:17,568 OPPORTUNITIES FOR ANY CHANGES 498 00:19:17,568 --> 00:19:19,503 PRIOR TO SUBMISSION OF YOUR 499 00:19:19,503 --> 00:19:22,272 APPLICATION. SO THAT IS A REALLY 500 00:19:22,272 --> 00:19:24,207 IMPORTANT THING THAT I WANT TO 501 00:19:24,207 --> 00:19:25,676 RELAY TODAY. THE OTHER THING YOU 502 00:19:25,676 --> 00:19:28,579 MIGHT SEE IS THAT PLANS FOR 503 00:19:28,579 --> 00:19:30,480 ENHANCING DIVERSE PERSPECTIVES 504 00:19:30,480 --> 00:19:35,519 OR PEDP ASPECT OF GRANTS OR 505 00:19:35,519 --> 00:19:36,587 CONFERENCE GRANT DIVERSITY PLANS 506 00:19:36,587 --> 00:19:38,789 OR EQUIPMENT PLANS TO ENHANCE 507 00:19:38,789 --> 00:19:39,957 DIVERSITY ALL HAVE BEEN ADJUSTED 508 00:19:39,957 --> 00:19:42,326 AND ARE NO LONGER BEING REQUIRED 509 00:19:42,326 --> 00:19:45,329 OR EVALUATED BUT RATHER THESE 510 00:19:45,329 --> 00:19:46,129 CONDITION THINGS THAT ARE 511 00:19:46,129 --> 00:19:49,900 MENTIONED IN THE GRANT IN A MORE 512 00:19:49,900 --> 00:19:54,237 GENERAL WAY TO RELAY IMPORTANT 513 00:19:54,237 --> 00:19:55,806 SCIENTIFIC STUDIES THAT ARE 514 00:19:55,806 --> 00:19:57,240 BEING CONDUCTED TO LOOK AT 515 00:19:57,240 --> 00:19:59,810 DIFFERENT POPULATIONS. JUST A 516 00:19:59,810 --> 00:20:02,579 NOTE ON AWARDS THEMSELVES, 517 00:20:02,579 --> 00:20:05,048 ISSUING AWARDS FOR COMPETING 518 00:20:05,048 --> 00:20:06,917 NON-COMPETING CONTINUATION AND 519 00:20:06,917 --> 00:20:09,019 ADMINISTRATIVE SUPPLEMENTS USING 520 00:20:09,019 --> 00:20:11,355 PREVIOUSLY APPROVED NEGOTIATED 521 00:20:11,355 --> 00:20:13,056 AND DIRECT COST RATES, ACCEPT 522 00:20:13,056 --> 00:20:15,726 FOR AWARDS UNDER WHICH THE 523 00:20:15,726 --> 00:20:17,060 INDIRECT COSTS ARE REIMBURSED AT 524 00:20:17,060 --> 00:20:19,496 A FIXED RATE ARE -- THAT IS 525 00:20:19,496 --> 00:20:21,498 ANOTHER ISSUE THAT HAS BEEN 526 00:20:21,498 --> 00:20:23,834 HIGHLIGHTED ON OUR GRANTS PAGE. 527 00:20:23,834 --> 00:20:26,303 SO THESE QR CODES AT THE BOTTOM, 528 00:20:26,303 --> 00:20:28,839 ONE IS A FOCUS ON GRANTS AN 529 00:20:28,839 --> 00:20:30,741 FUNDING INFORMATION STATUS. 530 00:20:30,741 --> 00:20:33,176 THESE ARE LATEST CHANGES 531 00:20:33,176 --> 00:20:34,244 IMPACTING NIH GRANTS 532 00:20:34,244 --> 00:20:36,046 ADMINISTRATION AND FUNDING, A 533 00:20:36,046 --> 00:20:38,482 LOT OF THE POINTS I MENTIONED 534 00:20:38,482 --> 00:20:40,951 ARE POLLED FROM THAT PARTICULAR 535 00:20:40,951 --> 00:20:42,653 WEBSITE SO ALL THAT IS PUBLICLY 536 00:20:42,653 --> 00:20:44,021 AVAILABLE THAT YOU CAN LOOK AT 537 00:20:44,021 --> 00:20:45,922 AND SEE. THE ONE QR CODE ON THE 538 00:20:45,922 --> 00:20:48,258 RIGHT, THE ONE IN BLACK IS 539 00:20:48,258 --> 00:20:51,228 INFORMATION ON NIH TERMINATED 540 00:20:51,228 --> 00:20:53,430 GRANTS. SO YOU CAN ACCESS THE 541 00:20:53,430 --> 00:20:55,465 GRANTS THAT HAVE BEEN TERMINATED 542 00:20:55,465 --> 00:20:57,734 HERE AS WELL. THERE IS AN 543 00:20:57,734 --> 00:20:59,970 ACCOMPANYING PDF THAT DESCRIBES 544 00:20:59,970 --> 00:21:01,338 THOSE TWO. SO I WANT TO MAKE 545 00:21:01,338 --> 00:21:02,372 SURE THOSE ARE PUBLICLY 546 00:21:02,372 --> 00:21:04,174 AVAILABLE RESOURCES FOR YOU IF 547 00:21:04,174 --> 00:21:05,275 YOU ARE INTERESTED OR AFFECTED 548 00:21:05,275 --> 00:21:08,078 BY ANY OF THESE ACTIVITIES. 549 00:21:08,078 --> 00:21:10,013 PLEASE GO TO THE NEXT -- I GUESS 550 00:21:10,013 --> 00:21:12,049 ONE MORE THING I WOULD SAY HERE. 551 00:21:12,049 --> 00:21:14,518 GO BACK ONE, APOLOGIES. THE 552 00:21:14,518 --> 00:21:15,519 ONLY OTHER THING I WOULD SAY 553 00:21:15,519 --> 00:21:22,659 ABOUT THIS SLIDE IS THAT I DON'T 554 00:21:22,659 --> 00:21:32,335 KNOW IF YOU CAN GO BACK ONE. 555 00:21:32,335 --> 00:21:37,007 THANK YOU. ARE THERE HAS BEEN A 556 00:21:37,007 --> 00:21:39,576 PROCESS WITHIN FEDERAL 557 00:21:39,576 --> 00:21:41,945 GOVERNMENT BROADLY BUT ALSO 558 00:21:41,945 --> 00:21:44,147 WITHIN NIH AND WE EXPERIENCED 559 00:21:44,147 --> 00:21:46,183 THOSE IN FORCE REDUCTIONS. OUR 560 00:21:46,183 --> 00:21:48,885 STAFF IS REDUCED. ALSO THROUGH A 561 00:21:48,885 --> 00:21:50,053 SERIES OF CONSOLIDATIONS IN 562 00:21:50,053 --> 00:21:51,321 PARTICULAR AREAS OF ACTIVITY 563 00:21:51,321 --> 00:21:55,058 LIKE I MENTIONED IN TERMS OF 564 00:21:55,058 --> 00:21:56,326 CENTRALIZING PEER REVIEW, 565 00:21:56,326 --> 00:21:59,896 CONSOLIDATING MORE CENTRALLY 566 00:21:59,896 --> 00:22:00,831 MORE CONSOLIDATIONS TAKE PLACE 567 00:22:00,831 --> 00:22:09,172 IN OTHER AREAS THAT ARE COMMON. 568 00:22:09,172 --> 00:22:11,975 THIS IS ONGOING IN FEDERAL SPACE 569 00:22:11,975 --> 00:22:15,645 BUT I WANT TO TAKE A MOMENT TO 570 00:22:15,645 --> 00:22:16,513 RECOGNIZE REDUCTIONS IN FORCE 571 00:22:16,513 --> 00:22:18,081 AND OTHER CHANGES WE HAVE 572 00:22:18,081 --> 00:22:20,884 EXPERIENCED SO THAT YOU ARE 573 00:22:20,884 --> 00:22:31,394 AWARE OF WHAT'S HAPPENING. ALL 574 00:22:34,197 --> 00:22:38,235 NCATS ARE EDITING TO -- SUBMIT 575 00:22:38,235 --> 00:22:39,603 YOUR GRANT APPLICATION TO MAKE 576 00:22:39,603 --> 00:22:40,637 SURE YOU ARE FOLLOWING THE 577 00:22:40,637 --> 00:22:42,339 INSTRUCTIONS WITHIN THE FORMATS 578 00:22:42,339 --> 00:22:46,042 THE NEXT SLIDE, JUST IN TERMS OF 579 00:22:46,042 --> 00:22:48,612 REDUCTIONS IN FORCE. I WANT THE 580 00:22:48,612 --> 00:22:51,648 TAKE A MOMENT NCATS HAS HAD 36 581 00:22:51,648 --> 00:22:55,152 STAFF DEPART THROUGH VARIOUS 582 00:22:55,152 --> 00:22:56,653 MEANS DURING THIS TIME. ALL THE 583 00:22:56,653 --> 00:23:00,891 STAFF LOSSES ARE HAVE BEEN 584 00:23:00,891 --> 00:23:03,026 DIFFICULT. EACH PERSON PLAYED A 585 00:23:03,026 --> 00:23:04,361 KEY ROLE ADVANCING THE SCIENCE 586 00:23:04,361 --> 00:23:05,729 AND OPERATION OF NCATS AND I 587 00:23:05,729 --> 00:23:09,499 WOULD BE REMISTO RECOGNIZE AT 588 00:23:09,499 --> 00:23:10,901 LEAST TO NOT RECOGNIZE THOSE 589 00:23:10,901 --> 00:23:11,935 INCREDIBLE LEADERS T N CATS AND 590 00:23:11,935 --> 00:23:13,970 ACROSS THE NIH SO I WANT TO TAKE 591 00:23:13,970 --> 00:23:15,338 A MOMENT TO RECOGNIZE THE 592 00:23:15,338 --> 00:23:19,009 LEADERS AT NCATS WHO HAVE 593 00:23:19,009 --> 00:23:22,546 DEPARTED THEIR LEADERSHIP ROLES 594 00:23:22,546 --> 00:23:25,882 HERE. JUST SAY HOW IMPORTANT 595 00:23:25,882 --> 00:23:27,617 THEY HAVE BEEN TO WHAT WE DO AT 596 00:23:27,617 --> 00:23:30,453 NCATS. WE WILL CONTINUE TO 597 00:23:30,453 --> 00:23:32,522 CONDUCT A LOT OF THE ACTIVITIES 598 00:23:32,522 --> 00:23:34,124 THEY HAVE SUPPORTED BUT THEY 599 00:23:34,124 --> 00:23:42,132 WILL BE SORELY MISSED. TALK A 600 00:23:42,132 --> 00:23:45,769 MOMENT TO RECOGNIZE THEM. ON THE 601 00:23:45,769 --> 00:23:53,009 NEXT SLIDE, GIVEN THE LOGISTICAL 602 00:23:53,009 --> 00:23:55,378 AND ONGOING CHANGES, THE LAST 603 00:23:55,378 --> 00:23:56,880 DAY OF FEBRUARY, IT IS A RARE 604 00:23:56,880 --> 00:23:58,215 DAY IN FEBRUARY BECAUSE 605 00:23:58,215 --> 00:23:59,749 SOMETIMES A DITCH DAY WE HAD A 606 00:23:59,749 --> 00:24:02,986 MAKE THE DIFFICULT DECISION TO 607 00:24:02,986 --> 00:24:05,655 CANCEL PLANNED JOINT FDA AND NIH 608 00:24:05,655 --> 00:24:06,456 RARE DISEASE DAY. IT IS 609 00:24:06,456 --> 00:24:07,858 IMPORTANT TO KNOW FOR EVERYONE 610 00:24:07,858 --> 00:24:09,226 THAT WHILE THE EVENT WILL NOT 611 00:24:09,226 --> 00:24:10,794 TAKE PLACE THIS YEAR, OUR 612 00:24:10,794 --> 00:24:12,462 DEDICATION TO RARE DISEASE 613 00:24:12,462 --> 00:24:14,931 COMMUNITY HAS NOT CHANGED. NIH 614 00:24:14,931 --> 00:24:16,433 AND THE FDA REMAIN FIRMLY 615 00:24:16,433 --> 00:24:17,901 COMMITTED TO ACCELERATING THE 616 00:24:17,901 --> 00:24:19,903 DEVELOPMENT OF TREATMENTS AND 617 00:24:19,903 --> 00:24:22,372 CURES AND TO OFFERING RESOURCES 618 00:24:22,372 --> 00:24:24,875 THAT PROVIDE HOPE AND SUPPORT TO 619 00:24:24,875 --> 00:24:26,076 MILLIONS ACROSS THE COUNTRY 620 00:24:26,076 --> 00:24:28,044 AFFECTED BY RARE DISEASE. THOUGH 621 00:24:28,044 --> 00:24:30,280 NOT ABLE TO HOST RARE DISEASE 622 00:24:30,280 --> 00:24:32,949 DAY THIS YEAR, WE WERE STILL 623 00:24:32,949 --> 00:24:34,517 ABLE TO LIGHT UP THE NIGHT AT 624 00:24:34,517 --> 00:24:37,187 BUILDING ONE ON THE NIH MAIN 625 00:24:37,187 --> 00:24:40,991 CAMPUS. AND DOMINIQUE 626 00:24:40,991 --> 00:24:42,692 (INDISCERNIBLE) DIRECTOR OF RARE 627 00:24:42,692 --> 00:24:44,928 DISEASE DIVISION AT NCATS AND I 628 00:24:44,928 --> 00:24:47,397 WERE ABLE TO BE THERE AND TAKE 629 00:24:47,397 --> 00:24:52,569 PICTURE ON THAT NIGHT AND JOHN 630 00:24:52,569 --> 00:24:55,005 BURKELOE CHIEF OF STAFF WHO IS 631 00:24:55,005 --> 00:24:57,574 ALSO RETIRENING A FEW DAYS IS -- 632 00:24:57,574 --> 00:24:59,542 RETIRING IN A FEW DAYS SO WANT 633 00:24:59,542 --> 00:25:01,778 TO ACKNOWLEDGE FOLKS THAT 634 00:25:01,778 --> 00:25:03,046 CELEBRATE RARE DISEASE DAY AND 635 00:25:03,046 --> 00:25:06,049 ACKNOWLEDGE WE WILL HOPEFULLY 636 00:25:06,049 --> 00:25:08,385 GET BACK ON -- WHEN WE RESUME 637 00:25:08,385 --> 00:25:15,358 THOSE ACTIVITIES. THIS IS A 638 00:25:15,358 --> 00:25:19,663 SLIDE ON THE BUDGET AS STANDS. 639 00:25:19,663 --> 00:25:23,433 AS YOU KNOW WE ARE CURRENTLY IN 640 00:25:23,433 --> 00:25:25,235 FULL YEAR CONTINUING RESOLUTION 641 00:25:25,235 --> 00:25:26,636 SO BUDGETS LOOKS THE SAME AS 642 00:25:26,636 --> 00:25:29,606 LAST YEAR AS FULL YEAR 643 00:25:29,606 --> 00:25:30,774 CONTINUING RESOLUTION DOES AND 644 00:25:30,774 --> 00:25:37,180 WE DO NOT YET KNOW THE UPSHOT OF 645 00:25:37,180 --> 00:25:38,315 FY 2026 BUDGET. WE WILL TALK 646 00:25:38,315 --> 00:25:43,453 ABOUT THAT AT THE NEXT COUNCIL. 647 00:25:43,453 --> 00:25:45,555 THE PRESIDENT'S BUDGET WILL BE 648 00:25:45,555 --> 00:25:49,159 THE FIRST THING THAT KEEPS UP 649 00:25:49,159 --> 00:25:51,761 THAT PROCESS. JUST WANT TO GIVE 650 00:25:51,761 --> 00:25:54,331 YOU A SENSE OF THE BUDGET AT 651 00:25:54,331 --> 00:25:56,366 $928 MILLION FOR FY 25 TO 652 00:25:56,366 --> 00:25:57,767 CONTINUE THOSE ACTIVITIES. IF 653 00:25:57,767 --> 00:25:59,269 YOU WOULD LIKE TO LEARN MORE 654 00:25:59,269 --> 00:26:01,938 LOOK AT QR CODE TO UNDERSTAND 655 00:26:01,938 --> 00:26:06,076 HOW THE BUDGET BREAKDOWNS 656 00:26:06,076 --> 00:26:07,877 ACTUALLY UNROLE. THE NEXT SLIDE, 657 00:26:07,877 --> 00:26:10,213 I MENTION THE IMPACTS OF THE 658 00:26:10,213 --> 00:26:12,082 STAFF REDUCTIONS IN THE PEOPLE 659 00:26:12,082 --> 00:26:13,616 WHO WERE AFFECTED BY THAT BUT 660 00:26:13,616 --> 00:26:15,819 ALSO I WANT TO HIGHLIGHT KEEFE 661 00:26:15,819 --> 00:26:17,187 STAFF ADDITIONS OVER THIS TIME 662 00:26:17,187 --> 00:26:19,689 TOO. WE ARE VERY EXCITED TO HAVE 663 00:26:19,689 --> 00:26:21,391 THESE FOLKS ON OUR LEADERSHIP 664 00:26:21,391 --> 00:26:23,960 TEAM AND HOPE YOU WILL BE ABLE 665 00:26:23,960 --> 00:26:25,962 TO INTERACT WITH THEM AT THE 666 00:26:25,962 --> 00:26:27,564 NEXT IN PERSON COUNCIL MEETING 667 00:26:27,564 --> 00:26:29,199 SO TAKE A MOMENT TO HIGHLIGHT 668 00:26:29,199 --> 00:26:31,868 THESE FOLKS. SOME OF WHOM YOU 669 00:26:31,868 --> 00:26:34,337 PROBABLY KNOW FROM BEFORE BUT 670 00:26:34,337 --> 00:26:35,572 BECAUSE I THINK THEY WERE ON THE 671 00:26:35,572 --> 00:26:37,173 CUSP IN SEPTEMBER OF COMING ON 672 00:26:37,173 --> 00:26:39,042 BOARD BUT I WANT TO HIGHLIGHT 673 00:26:39,042 --> 00:26:40,210 THEM AGAIN FOR THIS COUNCIL. SO 674 00:26:40,210 --> 00:26:42,145 WE ARE HAPPY TO HAVE THESE FOLKS 675 00:26:42,145 --> 00:26:44,180 IN LEADERSHIP POSITIONS TO HELP 676 00:26:44,180 --> 00:26:49,019 US MOVE FORWARD. NEXT SLIDE I 677 00:26:49,019 --> 00:26:51,354 WANT TO GET INTO SOME OF THE 678 00:26:51,354 --> 00:26:52,689 ACTIVITIES THAT WE HAVE BEEN 679 00:26:52,689 --> 00:26:56,826 DOING SINCE WE LAST MET. ONE OF 680 00:26:56,826 --> 00:26:58,328 THOSE THINGS, I WAS ABLE TO 681 00:26:58,328 --> 00:27:00,196 ATTEND THE 13TH ANNUAL HOOP ON 682 00:27:00,196 --> 00:27:02,899 THE HILL MEETING THROUGH CURE 683 00:27:02,899 --> 00:27:05,368 SMA. SO I WANT TA TAKE A MOMENT 684 00:27:05,368 --> 00:27:06,936 TO THANK CURE SMA FOR THAT 685 00:27:06,936 --> 00:27:10,073 INVITATION TO GIVE A KEYNOTE AT 686 00:27:10,073 --> 00:27:12,242 THEIR HOPE ON THE HILL EVENT. 687 00:27:12,242 --> 00:27:16,946 SMA IS A DEVASTATING RARE 688 00:27:16,946 --> 00:27:18,181 DISEASE BUT THIS GROUP HAS COME 689 00:27:18,181 --> 00:27:19,883 TOGETHER AT INCREDIBLE FASHION 690 00:27:19,883 --> 00:27:25,088 TO ADVANCE ALREADY THREE 691 00:27:25,088 --> 00:27:26,923 APPROVED THERAPEUTICS AND THEY 692 00:27:26,923 --> 00:27:29,392 HAVE APPROVED OTHERS ON THE 693 00:27:29,392 --> 00:27:30,527 PIPELINE ON THE WAY. AS RARE 694 00:27:30,527 --> 00:27:31,761 DISEASE GOES THAT'S ALSO QUITE 695 00:27:31,761 --> 00:27:34,130 RARE TO HAVE THREE APPROVED 696 00:27:34,130 --> 00:27:35,698 DISEASES THAT CAN HELP THIS 697 00:27:35,698 --> 00:27:37,267 PARTICULAR DISEASE. IT WAS 698 00:27:37,267 --> 00:27:39,269 ENERGIZING, INSPIRING, TO BE 699 00:27:39,269 --> 00:27:40,537 WITH THEM TO UNDERSTAND WHAT 700 00:27:40,537 --> 00:27:42,806 MAKES THEIR SORT OF SECRET SAUCE 701 00:27:42,806 --> 00:27:45,108 AND HOW THEY DO THEIR WOR WORK.I 702 00:27:45,108 --> 00:27:46,509 WAS TRYING TO GET A SENSE WHAT 703 00:27:46,509 --> 00:27:47,977 THAT WAS WHEN I WAS THERE. ONE 704 00:27:47,977 --> 00:27:51,047 ASPECT IS THAT THEY HAVE A 705 00:27:51,047 --> 00:27:52,348 TRANSLATIONAL SCIENCE ADVISORY 706 00:27:52,348 --> 00:27:55,552 COUNCIL AS PARTS OF THE CURE SMA 707 00:27:55,552 --> 00:27:57,487 BOARD. I THINK ONE OF THE KEY 708 00:27:57,487 --> 00:27:58,888 FEATURES OF THIS IS THEY REALLY 709 00:27:58,888 --> 00:28:01,491 HAVE THAT FOCUS OF TRANSLATIONAL 710 00:28:01,491 --> 00:28:04,461 SCIENCE. SO PERHAPS THIS MIGHT 711 00:28:04,461 --> 00:28:06,262 BE SOMETHING OTHER GROUPS COULD 712 00:28:06,262 --> 00:28:08,631 CONSIDER AS BEST PRACTICE TO 713 00:28:08,631 --> 00:28:10,100 HAVE GROUP OF PEOPLE THINKING 714 00:28:10,100 --> 00:28:12,335 ABOUT TRANSLATIONAL IMPACTS AND 715 00:28:12,335 --> 00:28:15,672 TRANSLATIONAL SCIENCE FOR THE 716 00:28:15,672 --> 00:28:17,173 PARTICULAR DISEASES THEY ARE 717 00:28:17,173 --> 00:28:18,308 WORKING THROUGH. THERE ARE 718 00:28:18,308 --> 00:28:19,542 PROBABLY MANY OTHER THINGS IN 719 00:28:19,542 --> 00:28:23,780 TERMS OF SECRET SAUCE THAT CURE 720 00:28:23,780 --> 00:28:26,249 SMA HAS, HOPEFULLY THAT WILL BE 721 00:28:26,249 --> 00:28:27,150 INTERACTIONS YOU CAN HAVE WITH 722 00:28:27,150 --> 00:28:28,651 THEM TO LEARN FROM THEM AS WELL, 723 00:28:28,651 --> 00:28:29,886 I HAD A GREAT OPPORTUNITY TO 724 00:28:29,886 --> 00:28:31,521 LEARN FROM THEM AND IT WAS A 725 00:28:31,521 --> 00:28:32,689 FANTASTIC EXPERIENCE SO I WOULD 726 00:28:32,689 --> 00:28:34,390 LIKE TO THANK THEM FOR THAT 727 00:28:34,390 --> 00:28:37,927 INVITATION. THE NEXT SLIDE IS 728 00:28:37,927 --> 00:28:40,029 ABOUT AN OPPORTUNITY I WAS 729 00:28:40,029 --> 00:28:42,799 INVITED TO SPEAK ON HILL ABOUT 730 00:28:42,799 --> 00:28:45,001 THE NATIONAL CLINICAL COHORT 731 00:28:45,001 --> 00:28:47,170 COLLABORATIVE OR NC 3 CLINICAL, 732 00:28:47,170 --> 00:28:49,506 AS WELL AS BROADER ARTIFICIAL 733 00:28:49,506 --> 00:28:51,574 INTELLIGENCE AI INITIATIVES WE 734 00:28:51,574 --> 00:28:54,377 SUPPORT AT NCATS. IT IS ALWAYS 735 00:28:54,377 --> 00:28:55,411 GOOD WHEN CONGRESS SHOWS 736 00:28:55,411 --> 00:28:56,012 INTEREST IN THE WORK THAT YOU 737 00:28:56,012 --> 00:28:57,547 ARE DOING AND INVITES YOU TO 738 00:28:57,547 --> 00:28:58,615 COME TALK TO THEM ABOUT WHAT YOU 739 00:28:58,615 --> 00:29:01,684 ARE DOING. BUT I CAN SAY IT 740 00:29:01,684 --> 00:29:04,821 WASN'T REALLY ME WHO MAKES THAT 741 00:29:04,821 --> 00:29:05,955 HAPPEN, THE PEOPLE IN THE 742 00:29:05,955 --> 00:29:08,858 BACKGROUND OF THIS SLIDE WHO ARE 743 00:29:08,858 --> 00:29:11,594 THE ONES WHETHER REALLY MAKE THE 744 00:29:11,594 --> 00:29:13,096 CONVERSATIONS SING. THEY ARE THE 745 00:29:13,096 --> 00:29:14,464 EXPERTS IN THIS SPACE AND REALLY 746 00:29:14,464 --> 00:29:19,202 DID A GREAT JOB TALKING TO 747 00:29:19,202 --> 00:29:22,438 SENATOR MARK HEINRICH STAFFER 748 00:29:22,438 --> 00:29:26,342 AND SENATOR MIC ROUNDS. SO WE 749 00:29:26,342 --> 00:29:27,277 HAD BOTH SIDES REPRESENTED AND 750 00:29:27,277 --> 00:29:29,279 IT WAS GREAT TO TALK HOW WE WERE 751 00:29:29,279 --> 00:29:31,447 THINKING SPEEDING INNOVATION 752 00:29:31,447 --> 00:29:32,749 THROUGH N 3C SO I WANT TO 753 00:29:32,749 --> 00:29:33,816 RECOGNIZE THE GROUP FOR DOING 754 00:29:33,816 --> 00:29:35,752 THAT BUT ALSO RELAY THAT WE ARE 755 00:29:35,752 --> 00:29:38,254 ALSO ACTIVELY PURSUING THESE 756 00:29:38,254 --> 00:29:41,357 SORTS OF ENGAGEMENTS EFFORTS ON 757 00:29:41,357 --> 00:29:45,228 THE HILL TOO. THE NEXT SLIDE IS 758 00:29:45,228 --> 00:29:46,262 IS ONE OTHER ACTIVITY WE 759 00:29:46,262 --> 00:29:47,931 RECENTLY HAD THROUGH OUR DPI 760 00:29:47,931 --> 00:29:51,634 RESEARCH DAY. WE HAVE AN 761 00:29:51,634 --> 00:29:52,969 INCREDIBLY TALENTED TRAINING 762 00:29:52,969 --> 00:29:57,874 DIRECTOR IN BRAIN EARLY SHE 763 00:29:57,874 --> 00:29:59,776 OVERSEES MANY TALENTED NCATS 764 00:29:59,776 --> 00:30:01,177 TRAINEES AND POST DOCS AND WE 765 00:30:01,177 --> 00:30:02,645 ARE ABLE TO CELEBRATE A LOT OF 766 00:30:02,645 --> 00:30:03,246 WORK THEY HAVE BEEN DOING 767 00:30:03,246 --> 00:30:08,651 THROUGH POSTER SESSIONS AND 768 00:30:08,651 --> 00:30:09,886 SHORT TALKS. AT THE END OF THE 769 00:30:09,886 --> 00:30:11,020 DAY WE HAD A MOMENT TO CELEBRATE 770 00:30:11,020 --> 00:30:13,556 THE WORK THEY HAVE BEEN DOING 771 00:30:13,556 --> 00:30:15,225 AND RAISE A TOAST TO EACH OTHER 772 00:30:15,225 --> 00:30:17,560 FOR ALL THOSE ACTIVITIES. THEY 773 00:30:17,560 --> 00:30:19,729 ARE REALLY LIFE BLOOD OF WHAT WE 774 00:30:19,729 --> 00:30:21,431 DO AT NCATS IN YOUR TRAINING 775 00:30:21,431 --> 00:30:23,132 PROGRAMS AND IN OUR INTRAMURAL 776 00:30:23,132 --> 00:30:25,802 PROGRAMS TOO. SO I WANT TO 777 00:30:25,802 --> 00:30:28,204 RECOGNIZE THAT. IN TERMS OF ALSO 778 00:30:28,204 --> 00:30:30,673 WHILE ON THE TOPIC OF INTRAMURAL 779 00:30:30,673 --> 00:30:33,042 PROGRAMS, GO TO NEXT SLIDE, I 780 00:30:33,042 --> 00:30:33,843 MENTIONED THE REPRODUCIBILITY 781 00:30:33,843 --> 00:30:35,211 ASPECT AND WHY THAT IS SO 782 00:30:35,211 --> 00:30:37,247 IMPORTANT TO NCATS. ON THE THE 783 00:30:37,247 --> 00:30:41,184 NEXT SLIDE I SHOW THERE IS 784 00:30:41,184 --> 00:30:42,819 SOMETHING CALLED ASSAY GUIDANCE 785 00:30:42,819 --> 00:30:44,687 MANUAL. THIS ASSAY GUIDANCE 786 00:30:44,687 --> 00:30:47,790 MANUAL KNOWN AS AGM FOR SHORT, 787 00:30:47,790 --> 00:30:50,426 THIS IS REALLY A WORLD-CLASS 788 00:30:50,426 --> 00:30:51,928 SOURCE OF GUIDELINES AND BEST 789 00:30:51,928 --> 00:30:53,496 PRACTICES FOR DANCING 790 00:30:53,496 --> 00:30:55,732 TRANSLATION -- ADVANCING 791 00:30:55,732 --> 00:30:57,500 TRANSLATIONAL SCIENCES AN 792 00:30:57,500 --> 00:30:58,635 RESEARCHING THE PRE-CLINICAL 793 00:30:58,635 --> 00:30:59,469 DEVELOPMENT SPACE OFFERS 794 00:30:59,469 --> 00:31:00,837 TRAINING AND INSIGHT FOR THOSE 795 00:31:00,837 --> 00:31:02,405 WHO WANT TO BECOME TRANSLATIONAL 796 00:31:02,405 --> 00:31:06,909 SCIENTISTS. THIS IS REALLY ABOUT 797 00:31:06,909 --> 00:31:08,945 COMMUNITY DEVELOP LABORATORY 798 00:31:08,945 --> 00:31:11,814 PRACTICES IN THAT EARLY 799 00:31:11,814 --> 00:31:13,516 TRANSLATIONAL RESEARCH PHASE, 800 00:31:13,516 --> 00:31:16,486 THINGS LIKE ROBUST ASSAY 801 00:31:16,486 --> 00:31:18,855 DEVELOPMENT ANALYTICAL 802 00:31:18,855 --> 00:31:21,624 TECHNOLOGIES, DATA ANALYSIS 803 00:31:21,624 --> 00:31:22,759 TOOLS, PRE-CLINICAL DRUG 804 00:31:22,759 --> 00:31:24,227 DISCOVERY STANDARDS, ALL THOSE 805 00:31:24,227 --> 00:31:26,262 ASPECTS ARE AREAS WHICH THE 806 00:31:26,262 --> 00:31:28,164 ASSAY GUIDANCE MANUAL COVERS AND 807 00:31:28,164 --> 00:31:33,202 WE HAVE WEBINARS AND WORKSHOPS 808 00:31:33,202 --> 00:31:34,604 SELECT SPECIFIC PROGRAMS TO TALK 809 00:31:34,604 --> 00:31:36,639 ABOUT THAT ARE TIMELY AND 810 00:31:36,639 --> 00:31:41,611 RELEVANT FOR MOVING FORWARD. ONE 811 00:31:41,611 --> 00:31:43,012 REASON WE HAVE HERE IN SILICO 812 00:31:43,012 --> 00:31:45,148 DRUG DISCOVERY WORKSHOP TALKING 813 00:31:45,148 --> 00:31:46,049 ARTIFICIAL INTELLIGENCE AND 814 00:31:46,049 --> 00:31:48,484 MACHINE LEARNING, BECAUSE IT IS 815 00:31:48,484 --> 00:31:50,286 QUITE A PIVOTAL ROLE IN 816 00:31:50,286 --> 00:31:51,554 ACCELERATING DRUG DISCOVERY AND 817 00:31:51,554 --> 00:31:53,823 HOW WE THINK ABOUT TRANSLATIONAL 818 00:31:53,823 --> 00:31:56,659 SCIENCE. OUR NCATS TEAMS ARE 819 00:31:56,659 --> 00:31:58,561 APPLYING AI TO ENHANCE HIGH 820 00:31:58,561 --> 00:32:01,531 THROUGH PUT SCREENING BY 821 00:32:01,531 --> 00:32:03,132 DETECTING ASSAY ARTIFACTS AND 822 00:32:03,132 --> 00:32:05,668 OPTIMIZING COMPOUND PROPERTIES 823 00:32:05,668 --> 00:32:07,570 LIKE METABOLIC STABILITY, 824 00:32:07,570 --> 00:32:10,807 ABSORPTION, FOR DISEASES LIKE OR 825 00:32:10,807 --> 00:32:12,275 AND TOXICITY. THESE ARE METHODS 826 00:32:12,275 --> 00:32:15,144 THAT ARE IMPORTANT FOR HELPING 827 00:32:15,144 --> 00:32:16,746 STUDY THINGS LIKE CANCER, RARE 828 00:32:16,746 --> 00:32:18,881 DISEASE INFECTIOUS DISEASE AND 829 00:32:18,881 --> 00:32:19,749 ALSO ADVANCING THE NEXT 830 00:32:19,749 --> 00:32:22,251 GENERATION OF MODALITIES, THAT 831 00:32:22,251 --> 00:32:23,920 ARE GOING TO BE IMPORTANT FOR 832 00:32:23,920 --> 00:32:25,421 DEVELOPING THESE SORTS OF 833 00:32:25,421 --> 00:32:26,889 THERAPEUTICS. THINGS LIKE 834 00:32:26,889 --> 00:32:29,759 MOLECULAR GLUES, PROTAX OR THE 835 00:32:29,759 --> 00:32:31,527 PROTEOLYSIS TARGETING CHIMERAS, 836 00:32:31,527 --> 00:32:34,530 TARGET ANTIBODIES OR FANTASTIC 837 00:32:34,530 --> 00:32:35,965 BODIES AN GENE TARGETED THERAPY. 838 00:32:35,965 --> 00:32:37,133 THERE IS A VARIETY OF THINGS IN 839 00:32:37,133 --> 00:32:38,868 THE ASSAY GUIDANCE MANUALNA ARE 840 00:32:38,868 --> 00:32:41,838 REALLY IMPORTANT. -- MANUAL THAT 841 00:32:41,838 --> 00:32:43,005 ARE REALLY IMPORTANT. FOR THIS 842 00:32:43,005 --> 00:32:44,107 PARTICULAR MEETING WE WERE 843 00:32:44,107 --> 00:32:45,141 THRILLED TO HAVE DAVID BAKER 844 00:32:45,141 --> 00:32:47,310 JOIN US AND AS YOU KNOW HE WAS 845 00:32:47,310 --> 00:32:49,779 AWARDED THE 2024 NOBEL PRIZE IN 846 00:32:49,779 --> 00:32:50,980 CHEMISTRY FOR HIS 847 00:32:50,980 --> 00:32:51,881 GROUND-BREAKING WORK IN 848 00:32:51,881 --> 00:32:54,917 COMPUTATIONAL PROTEIN DESIGN, 849 00:32:54,917 --> 00:32:57,186 ALONG WITH DENISE (INAUDIBLE) 850 00:32:57,186 --> 00:33:00,823 AND JOHN JUMPER FOR PROTEIN 851 00:33:00,823 --> 00:33:02,125 STRUCTURE PREDICTION AND THIS 852 00:33:02,125 --> 00:33:04,160 FIELD IS FUNDAMENTALLY RESHAPING 853 00:33:04,160 --> 00:33:06,396 OUR UNDERSTANDING OF BIOLOGY AND 854 00:33:06,396 --> 00:33:08,598 OPENING NEW DOORS FOR 855 00:33:08,598 --> 00:33:09,766 THERAPEUTIC DEVELOPMENT SO AN 856 00:33:09,766 --> 00:33:11,834 EXCITING MEETING. I HAVE PUT THE 857 00:33:11,834 --> 00:33:13,669 QR CODES HERE IN CASE YOU ARE 858 00:33:13,669 --> 00:33:14,604 INTERESTED IN HEARING THESE 859 00:33:14,604 --> 00:33:16,873 TALK. THE KEYNOTE ADDRESS BY 860 00:33:16,873 --> 00:33:18,975 MARTI HEAD IS DAY 1 AND DAVID 861 00:33:18,975 --> 00:33:21,677 BAKERS TALK ON DAY 2 SO I 862 00:33:21,677 --> 00:33:22,912 ENCOURAGE YOU TO LOOK AT THAT. 863 00:33:22,912 --> 00:33:26,215 THIS ALLOWED US TO HAVE DEEP 864 00:33:26,215 --> 00:33:28,551 DISCUSSIONS THAT WILL DIRECTLY 865 00:33:28,551 --> 00:33:30,987 SHAPE HOW QUICKLY AND HOW 866 00:33:30,987 --> 00:33:33,222 EFFECTIVELY NEW TREATMENTS CAN 867 00:33:33,222 --> 00:33:35,591 REACH PATIENTS AND ULTIMATELY 868 00:33:35,591 --> 00:33:37,727 SAVE LIVES SO THIS AGAIN IS 869 00:33:37,727 --> 00:33:39,662 QUINT ESSENTIALLY WHAT WE DO AT 870 00:33:39,662 --> 00:33:41,230 NCATS AND THIS WAS A FANTASTIC 871 00:33:41,230 --> 00:33:42,365 MEETING I WANTED TO HIGHLIGHT 872 00:33:42,365 --> 00:33:44,200 FOR YOU TODAY. GO ON THE NEXT 873 00:33:44,200 --> 00:33:45,668 SLIDE, ONE MORE FEATURE I WANTED 874 00:33:45,668 --> 00:33:47,236 TO TALK ABOUT THAT'S HAPPENED IN 875 00:33:47,236 --> 00:33:50,339 THE LAST FEW MONTHS SINCE WE 876 00:33:50,339 --> 00:33:52,909 LAST MET IS THAT OUR COUNCIL IS 877 00:33:52,909 --> 00:33:55,812 VERY FAMILIAR WITH SUCCESS OF 878 00:33:55,812 --> 00:33:58,080 OUR INTRAMURAL LABS NCATS LABS 879 00:33:58,080 --> 00:33:59,749 OR DIVISION OF PRE-CLINICAL 880 00:33:59,749 --> 00:34:00,783 INNOVATION BUT I WANT TO SHOW 881 00:34:00,783 --> 00:34:02,318 YOU THE RECORD OF CLINICAL 882 00:34:02,318 --> 00:34:06,322 SUCCESS THAT IT HAS HAD. OVER 883 00:34:06,322 --> 00:34:08,124 OUR 13 YEAR HISTORY, MUCH LIKE 884 00:34:08,124 --> 00:34:10,059 THE CLINICAL CENTER IS AMERICA'S 885 00:34:10,059 --> 00:34:11,894 HOSPITAL, NCATS HOUSES THE 886 00:34:11,894 --> 00:34:13,329 PRE-CLINICAL LABS THAT CONDUCTS 887 00:34:13,329 --> 00:34:14,096 COLLABORATIVE PRE-CLINICAL 888 00:34:14,096 --> 00:34:16,032 RESEARCH PROJECTS FOR CHRONIC 889 00:34:16,032 --> 00:34:17,834 AND RARE DISEASES DEVELOPING NEW 890 00:34:17,834 --> 00:34:19,969 METHODS AND TECHNOLOGIES THAT 891 00:34:19,969 --> 00:34:21,304 SPEED TRANSLATION AND ADVANCE 892 00:34:21,304 --> 00:34:23,072 THEM TO THE CLINIC. SO WE LIKE 893 00:34:23,072 --> 00:34:25,441 TO THINK FOR OURSELVES AS THE 894 00:34:25,441 --> 00:34:27,276 PRE-CLINICAL CENTER. TO DATE WE 895 00:34:27,276 --> 00:34:29,378 HAVE CONTRIBUTED TO OVER 56 896 00:34:29,378 --> 00:34:30,813 INVESTIGATIONAL NEW DRUGS THAT 897 00:34:30,813 --> 00:34:32,949 WE CAN POINT TO AND KNOW ABOUT. 898 00:34:32,949 --> 00:34:38,187 AND THEN FOUR OF ACTUALLY IN 899 00:34:38,187 --> 00:34:39,689 ADDITION THERE ARE FOUR OF THESE 900 00:34:39,689 --> 00:34:42,625 THAT HAVE NEW DRUG APPROVAL. 901 00:34:42,625 --> 00:34:48,464 OVER 56 I IND APPLICATIONS TO NW 902 00:34:48,464 --> 00:34:51,934 DRUG MODULES. LIKE GENE THERAPY. 903 00:34:51,934 --> 00:34:55,271 THE ONE HERE ON UP STAZA, THE 904 00:34:55,271 --> 00:34:57,206 FIRST GENETHERRY DELIVERED 905 00:34:57,206 --> 00:34:58,875 DIRECTLY TO THE BRAIN TO HELP 906 00:34:58,875 --> 00:35:00,710 CHILDREN WITH AADC DEFICIENCY. 907 00:35:00,710 --> 00:35:04,647 THIS WAS COLLABORATION WITH 908 00:35:04,647 --> 00:35:07,016 INTERNATIONAL GROUP IN TAIWAN 909 00:35:07,016 --> 00:35:08,951 AND IT WAS APPROVED BY E MA A 910 00:35:08,951 --> 00:35:10,753 FEW YEARS AGO AND MORE RECENTLY 911 00:35:10,753 --> 00:35:12,421 APPROVED BY THE FDA. WE ARE 912 00:35:12,421 --> 00:35:15,591 REALLY EXCITED TO SEE THAT. SO 913 00:35:15,591 --> 00:35:17,426 THIS IS ONE OF THOSE AREAS THAT 914 00:35:17,426 --> 00:35:19,362 WE HAVE DEVELOPED A WEBSITE NOW 915 00:35:19,362 --> 00:35:20,930 TO SHOW THIS. IF YOU CLICK 916 00:35:20,930 --> 00:35:22,131 THROUGH THE NEXT SLIDE I WANT TO 917 00:35:22,131 --> 00:35:23,165 GIVE YOU A SENSE WHAT YOU CAN 918 00:35:23,165 --> 00:35:24,534 FIND ON THIS WEBSITE BECAUSE I 919 00:35:24,534 --> 00:35:26,435 THINK IT IS CRITICAL TO HAVE 920 00:35:26,435 --> 00:35:27,370 THIS INFORMATION AVAILABLE. SO 921 00:35:27,370 --> 00:35:31,641 OUR WEBSITE SHOWS THESE 922 00:35:31,641 --> 00:35:33,676 INFORMATION ABOUT THESE 60 923 00:35:33,676 --> 00:35:37,346 INDs AND NDAs. IF YOU GO TO 924 00:35:37,346 --> 00:35:38,581 NEXT SLIDE HAND CLICK THROUGH 925 00:35:38,581 --> 00:35:41,684 EACH OF THESE INDs OR NDAs 926 00:35:41,684 --> 00:35:43,052 HAS A SPECIFIC CARD ON OUR 927 00:35:43,052 --> 00:35:46,622 WEBSITE AND YOU CAN CLICK ON THE 928 00:35:46,622 --> 00:35:48,558 APPROVED OR THE IND FOR THAT 929 00:35:48,558 --> 00:35:51,160 PARTICULAR CARD. IF YOU WERE TO 930 00:35:51,160 --> 00:35:55,064 CLICK ON UPSTAZA, GO TO THE NEXT 931 00:35:55,064 --> 00:35:56,566 SLIDE, WITHIN THOSE CARDS IT 932 00:35:56,566 --> 00:35:58,267 WILL THEN IF YOU CLICK ON IT IT 933 00:35:58,267 --> 00:35:59,635 WILL POP OUT TO EVEN MORE 934 00:35:59,635 --> 00:36:02,038 INFORMATION ABOUT THE NCATS 935 00:36:02,038 --> 00:36:05,575 CONTRIBUTIONS TO DEVELOPMENT OF 936 00:36:05,575 --> 00:36:08,811 THIS THERAPEUTIC OR IND AND MORE 937 00:36:08,811 --> 00:36:11,380 ABOUT THE DISEASE ITS MEANT FOR 938 00:36:11,380 --> 00:36:14,717 AND ITS INDICATION. SO IT IS A 939 00:36:14,717 --> 00:36:17,820 REALLY NICE CATALOG OF THESE. I 940 00:36:17,820 --> 00:36:20,323 THINK A REALLY NICE WAY OF 941 00:36:20,323 --> 00:36:21,857 CAPTURING COMMUNICATING NCATS 942 00:36:21,857 --> 00:36:23,793 SUCCESS IN THESE ACTIVITIES. SO 943 00:36:23,793 --> 00:36:30,333 YOU CAN GO TO NEXT SLIDE I ALSO 944 00:36:30,333 --> 00:36:32,568 WANTED TO PICK UP ON WHERE WE 945 00:36:32,568 --> 00:36:35,571 LEFT OFF THE LAST COUNCIL. IN 946 00:36:35,571 --> 00:36:36,706 WORKING WITH ALL OF OUR 947 00:36:36,706 --> 00:36:39,642 DIFFERENT DIVISIONS AND OFFICES 948 00:36:39,642 --> 00:36:41,811 WE FINISHED THE NCATS STRATEGIC 949 00:36:41,811 --> 00:36:43,279 PLAN AND MADE A FEW TWEAKS TO 950 00:36:43,279 --> 00:36:46,849 THE PLAN TO ENSURE WE ARE 951 00:36:46,849 --> 00:36:48,651 THINKING ABOUT THE HHS AND NIH 952 00:36:48,651 --> 00:36:52,688 PRIORITIES WITHIN THAT. WE HELD 953 00:36:52,688 --> 00:36:55,091 ALSO INTERNAL IMPLEMENTATION 954 00:36:55,091 --> 00:36:56,225 CONFERENCE. YOU ARE SEEING THE 955 00:36:56,225 --> 00:36:57,860 BEHIND THE SCENES PICTURES OF 956 00:36:57,860 --> 00:36:59,328 ALL THE STAFF AT NCATS WHO ARE 957 00:36:59,328 --> 00:37:01,897 CRITICAL IN HELPING SHAPE THE 958 00:37:01,897 --> 00:37:02,698 IMPLEMENTATION OF STRATEGIC 959 00:37:02,698 --> 00:37:05,701 PLAN. AND HOW WE ARE THINKING OF 960 00:37:05,701 --> 00:37:07,670 MOVING FORWARD TOGETHER IN A 961 00:37:07,670 --> 00:37:09,271 UNIFIED COORDINATED FASHION. WE 962 00:37:09,271 --> 00:37:12,942 ARE CONTINUING WORK IN THAT 963 00:37:12,942 --> 00:37:17,079 STRATEGIC PLAN SPACE MOVING FROM 964 00:37:17,079 --> 00:37:18,214 STRATEGIC PLANNING TO STRATEGIC 965 00:37:18,214 --> 00:37:19,882 DOING. NOTHING IS MORE EXCITING 966 00:37:19,882 --> 00:37:21,751 THAN BEING ABLE TO MOVE FORWARD 967 00:37:21,751 --> 00:37:25,621 IN THAT WAY. THE NEXT SLIDE I 968 00:37:25,621 --> 00:37:30,026 WANT TO GIVE YOU THE TIME LINE 969 00:37:30,026 --> 00:37:31,494 IN TERMS OF WHAT'S NEXT. YOU 970 00:37:31,494 --> 00:37:33,963 EXPERIENCED WITH ME AS PART OF 971 00:37:33,963 --> 00:37:35,097 THE COUNCIL OUR PLANNING PROCESS 972 00:37:35,097 --> 00:37:37,533 THAT WEPT THROUGH THIS STRATEGIC 973 00:37:37,533 --> 00:37:41,771 PLAN AND NOW WE HAVE AN INTERNAL 974 00:37:41,771 --> 00:37:44,573 IMPLEMENTATION TEAM LED BY ANIKA 975 00:37:44,573 --> 00:37:46,175 WAYMAN DEPUTY DIRECTOR AND WE 976 00:37:46,175 --> 00:37:48,577 WILL CONTINUE TO DEVELOP THAT 977 00:37:48,577 --> 00:37:50,946 AND WORK THROUGH IMPLEMENTATION 978 00:37:50,946 --> 00:37:53,182 THROUGH INITIATIVES AND OTHER 979 00:37:53,182 --> 00:37:54,884 PROGRAMS AND PROJECTS THAT NCATS 980 00:37:54,884 --> 00:37:57,687 WILL PURSUE. STAY TUNED ON THAT. 981 00:37:57,687 --> 00:38:00,423 THE NEXT SLIDE, ONE OF THE 982 00:38:00,423 --> 00:38:01,457 THINGS I WANT TO BRING UP, 983 00:38:01,457 --> 00:38:05,928 SOMETHING HAPPENED I THINK IN 984 00:38:05,928 --> 00:38:10,666 THE DISPLAY HERE BUT IT LOOKS 985 00:38:10,666 --> 00:38:11,934 LIKE SOME OF THE WORDS CROSSED 986 00:38:11,934 --> 00:38:13,069 EACH OTHER. HOPEFULLY YOU CAN 987 00:38:13,069 --> 00:38:16,105 SEE OKAY ON YOUR SIDE. ONE THING 988 00:38:16,105 --> 00:38:17,606 I WANT TO BRING UP, THERE ARE 989 00:38:17,606 --> 00:38:21,477 SOME BARRIERS TO ACCELERATING 990 00:38:21,477 --> 00:38:24,980 OUR STRATEGIC PLAN ONE BARRIER 991 00:38:24,980 --> 00:38:29,018 IS AROUND THE IDEA NCATS IS 992 00:38:29,018 --> 00:38:32,655 PROHIBITED FROM CONDUCTING PHASE 993 00:38:32,655 --> 00:38:33,589 3 CLINICAL TRIALS. THIS IS A 994 00:38:33,589 --> 00:38:35,224 LONG STANDING PROHIBITION SINCE 995 00:38:35,224 --> 00:38:41,130 INCEPTION OF NCATS WE HAVE THE 996 00:38:41,130 --> 00:38:44,366 WORLD'S LEADING NATIONAL 997 00:38:44,366 --> 00:38:47,069 CLINICAL TRANSLATIONAL SCIENCE 998 00:38:47,069 --> 00:38:50,473 AWARDS PROGRAM WITH THAT, SINCE 999 00:38:50,473 --> 00:38:53,976 WE ARE PROHINTED FROM DOING 1000 00:38:53,976 --> 00:38:55,044 PHASE 3 CLINICAL TRIALS, IT 1001 00:38:55,044 --> 00:38:58,013 LEADS TO THIS IDEA WE MAY BE 1002 00:38:58,013 --> 00:38:59,415 UNDERUTILIZING CTSA PROGRAM. 1003 00:38:59,415 --> 00:39:03,853 THAT SAID, CTSA INSTITUTIONS ARE 1004 00:39:03,853 --> 00:39:06,455 STILL LEADERS IN THIS SPACE. 1005 00:39:06,455 --> 00:39:10,192 THEY CAN CONTINUE TO DO PHASE 3 1006 00:39:10,192 --> 00:39:12,328 COST JUST NCATS IS ABLE TO 1007 00:39:12,328 --> 00:39:14,730 SUPPORT THOSE. IF THEY ARE 1008 00:39:14,730 --> 00:39:16,065 SUPPORTED FROM ANOTHER CENTER, 1009 00:39:16,065 --> 00:39:17,566 THEY CAN PROCEED WITH THAT AND 1010 00:39:17,566 --> 00:39:19,268 THEY BRING THAT LEADERSHIP IN 1011 00:39:19,268 --> 00:39:19,869 CLINICAL REESSENTIAL AND 1012 00:39:19,869 --> 00:39:20,870 CLINICAL TRIALS TO TABLE AND 1013 00:39:20,870 --> 00:39:23,539 THAT VALUABLE. IF WE THINK ABOUT 1014 00:39:23,539 --> 00:39:25,207 THIS IN MORE TRANSLATIONAL 1015 00:39:25,207 --> 00:39:29,545 SCIENCE LEVEL OF ACTIVITY, 1016 00:39:29,545 --> 00:39:32,248 HAVING THIS WAYS IN WHICH WE CAN 1017 00:39:32,248 --> 00:39:34,283 THINK ABOUT REOF MOVING THIS AS 1018 00:39:34,283 --> 00:39:35,785 PROHIBITION IS CRITICAL FOR 1019 00:39:35,785 --> 00:39:38,821 ABILITY TO EVEN NAVIGATE OUR 1020 00:39:38,821 --> 00:39:40,890 ABILITY TO INNOVATE AROUND 1021 00:39:40,890 --> 00:39:42,291 CLINICAL TRIALS MORE. AND 1022 00:39:42,291 --> 00:39:43,759 WORKING TOGETHER WITH ALL OF OUR 1023 00:39:43,759 --> 00:39:45,027 PROGRAMS TO BE ABLE TO DO THAT. 1024 00:39:45,027 --> 00:39:48,564 SO H IS ONE OF THOSE AREAS THAT 1025 00:39:48,564 --> 00:39:52,668 I WANT TO MAKE SURE COUNCIL IS 1026 00:39:52,668 --> 00:39:54,670 AWARE OF, AND UNDERSTAND TOO WE 1027 00:39:54,670 --> 00:39:56,438 ARE WORKING THROUGH AND CAN 1028 00:39:56,438 --> 00:39:58,107 NAVIGATE THIS PROCESS VERY WELL 1029 00:39:58,107 --> 00:40:00,509 FOR EXAMPLE IN SOME WAYS WHEN WE 1030 00:40:00,509 --> 00:40:03,813 WERE WORKING IN THE COVID SPACE 1031 00:40:03,813 --> 00:40:05,414 A LOT OF PHASE 3 CLINICAL TRIALS 1032 00:40:05,414 --> 00:40:07,349 WERE SUPPORTED BY OPERATION WARP 1033 00:40:07,349 --> 00:40:10,252 SPEED OR BARTA OR OTHER SPACES 1034 00:40:10,252 --> 00:40:12,254 SO IT WASN'T NCATS DOLLARS THAT 1035 00:40:12,254 --> 00:40:14,223 SUPPORTED BUT ABLE TO BRING 1036 00:40:14,223 --> 00:40:15,691 CTSAs TO THE TABLE TO ADVANCE 1037 00:40:15,691 --> 00:40:18,093 THOSE TRIALS. SO WE DO PLAY A 1038 00:40:18,093 --> 00:40:19,795 DEEP ROLE IN THIS BUT THIS IS 1039 00:40:19,795 --> 00:40:21,797 ONE OF THOSE AREAS THAT CAN BE 1040 00:40:21,797 --> 00:40:27,036 VERY HELPFUL. NEXT SLIDE. I 1041 00:40:27,036 --> 00:40:28,437 MENTIONED TRADING EARLIER AND 1042 00:40:28,437 --> 00:40:30,005 HOW IMPORTANT THAT WAS 1043 00:40:30,005 --> 00:40:31,574 ESPECIALLY WITH THE INTRAMURAL 1044 00:40:31,574 --> 00:40:32,741 PROGRAM BUT I WANT TO FOCUS ON 1045 00:40:32,741 --> 00:40:34,777 THE EXTRAMURAL PROGRAM AND 1046 00:40:34,777 --> 00:40:37,780 LARGELY THROUGH CTSA SAFETY 1047 00:40:37,780 --> 00:40:42,218 GROUPS THIS IS A PAPER BY BOB 1048 00:40:42,218 --> 00:40:44,753 AND HIS GROUP TALKING ICORR. 1049 00:40:44,753 --> 00:40:47,122 THAT'S A SHORT COURSE THAT 1050 00:40:47,122 --> 00:40:48,424 TRANSLATIONAL AND CLINICAL SANS 1051 00:40:48,424 --> 00:40:50,426 SCIENCES TO ASSESS REAL WORLD 1052 00:40:50,426 --> 00:40:53,596 IMPACT OF RESEARCH THROUGH 1053 00:40:53,596 --> 00:40:55,431 CUSTOMER DISCOVERY, ABOUT WHAT 1054 00:40:55,431 --> 00:40:56,999 THE NEEDS ARE AND ADVANCING THE 1055 00:40:56,999 --> 00:41:02,071 SCIENCE H. NSF I-CORPS. THE NSF 1056 00:41:02,071 --> 00:41:03,339 HAS A PROGRAM SIMILAR TO THIS 1057 00:41:03,339 --> 00:41:05,407 THAT IS SUCCESSFUL SO WE HAVE 1058 00:41:05,407 --> 00:41:07,109 ADOPTED IT. SO WHAT THIS GROUP 1059 00:41:07,109 --> 00:41:17,453 DID IS EVALUATE THE 1060 00:41:28,130 --> 00:41:29,565 BUILDS SKILLS LIKE SYSTEMS 1061 00:41:29,565 --> 00:41:31,000 THINKING, COMMUNITY AND TEAM 1062 00:41:31,000 --> 00:41:33,402 SCIENCE AND COLLABORATION. WHAT 1063 00:41:33,402 --> 00:41:34,703 THIS GROUP ALSO SHOWED IS NOT 1064 00:41:34,703 --> 00:41:39,074 ONLY DOES IT DO THAT, 1065 00:41:39,074 --> 00:41:40,242 INTERESTINGLY PARTICIPANTS WHO 1066 00:41:40,242 --> 00:41:41,243 WENT THROUGH THIS PROGRAM 1067 00:41:41,243 --> 00:41:43,279 SURFACE QUALITIES LIKE 1068 00:41:43,279 --> 00:41:45,281 INTELLECTUAL HUMILITY, COGNITIVE 1069 00:41:45,281 --> 00:41:47,116 FLEXIBILITY AND THAT REMINDS US 1070 00:41:47,116 --> 00:41:50,719 THAT TRANSLATIONAL SCIENCE IS AS 1071 00:41:50,719 --> 00:41:54,189 MUCH ABOUT HOW WE THINK ABOUT 1072 00:41:54,189 --> 00:41:56,258 THE SCIENCE OPPOSED TO WHAT WE 1073 00:41:56,258 --> 00:41:59,662 DO IN THAT SCIENCE. I THOUGHT 1074 00:41:59,662 --> 00:42:01,597 THAT WAS A SALIENT THOUGHT 1075 00:42:01,597 --> 00:42:02,731 AROUND THIS PARTICULAR PAPER SO 1076 00:42:02,731 --> 00:42:03,832 I WANTED TO BRING IT TO YOUR 1077 00:42:03,832 --> 00:42:13,842 ATTENTION. NEXT SLIDE IS ANOTHER 1078 00:42:13,842 --> 00:42:14,877 SLIDE THAT TALKS TRAINING 1079 00:42:14,877 --> 00:42:16,979 PROGRAMS WE HAVE WITHIN THE CTSA 1080 00:42:16,979 --> 00:42:18,013 PROGRAM, THIS ONE IS ABOUT 1081 00:42:18,013 --> 00:42:22,151 CAREER DEVELOPMENT ANDCATION 1082 00:42:22,151 --> 00:42:24,253 SCHOLARS SO MORE EARLY CAREER 1083 00:42:24,253 --> 00:42:27,856 TYPES OF INVESTIGATORS. ANALYSIS 1084 00:42:27,856 --> 00:42:29,525 CONDUCTED HERE AT NCATS WITHIN 1085 00:42:29,525 --> 00:42:33,796 THE CTSA OFFICE IS WE LOOKED AT 1086 00:42:33,796 --> 00:42:37,766 HOW OUR CTSA SCHOLARS COMPARED 1087 00:42:37,766 --> 00:42:38,968 TO OTHER SCHOLARS ACROSS THE 1088 00:42:38,968 --> 00:42:41,837 NIH. SO THE NCATS SCHOLARS ARE 1089 00:42:41,837 --> 00:42:44,506 SHOWN IN A TALE COLOR AND THE 1090 00:42:44,506 --> 00:42:47,076 OTHER SCHOLARS ARE SHOWN IN A 1091 00:42:47,076 --> 00:42:48,644 GREEN COLOR. WE FOUND A HIGHER 1092 00:42:48,644 --> 00:42:50,079 PERCENTAGE OF NCATS SUPPORTED 1093 00:42:50,079 --> 00:42:51,547 SCHOLARS THAT APPLY FOR AND 1094 00:42:51,547 --> 00:42:53,182 RECEIVE AWARDS AFTER THEIR K 1095 00:42:53,182 --> 00:42:54,883 TRAINING COMPARED TO OTHER NIH 1096 00:42:54,883 --> 00:42:58,120 SUPPORTED SCHOLARS. OTHER NIH 1097 00:42:58,120 --> 00:42:59,888 SUPPORTED SCHOLARS HAVE HIGHER 1098 00:42:59,888 --> 00:43:01,023 PERCENTAGES OF SCHOLARS WHO 1099 00:43:01,023 --> 00:43:02,925 DON'T GO ON TO APPLY FOR 1100 00:43:02,925 --> 00:43:04,193 SUBSEQUENT FUNDING FROM NIH BUT 1101 00:43:04,193 --> 00:43:05,961 MAY GO ON TO OTHER AREAS. AND 1102 00:43:05,961 --> 00:43:08,697 GET THAT FUNDING. SO THAT MAY BE 1103 00:43:08,697 --> 00:43:09,832 RATIONALE FOR WHY WE SEE THIS 1104 00:43:09,832 --> 00:43:11,367 BUT I THINK IT IS ALSO THE FACT 1105 00:43:11,367 --> 00:43:15,371 THAT WE HAVE A ROBUST CAREER 1106 00:43:15,371 --> 00:43:16,605 DEVELOPMENT PROGRAM WITHIN THE 1107 00:43:16,605 --> 00:43:18,507 CTSA PROGRAM THAT IS AVAILABLE. 1108 00:43:18,507 --> 00:43:20,209 SO I WANT TO HIGHLIGHT THAT AND 1109 00:43:20,209 --> 00:43:24,413 COMMEND CTSA K DIRECTORS ON THE 1110 00:43:24,413 --> 00:43:27,383 WORK THEY ARE DO IN THAT SPACE. 1111 00:43:27,383 --> 00:43:32,821 THE NEXT SLIDE IS ONE OTHER 1112 00:43:32,821 --> 00:43:35,290 ADVERTISEMENT IF YOU WILL. VERY 1113 00:43:35,290 --> 00:43:39,128 RECENTLY AFTER A PERIOD OF VERY 1114 00:43:39,128 --> 00:43:43,766 LONG AND VERY EXCELLENT DETAILED 1115 00:43:43,766 --> 00:43:45,100 WORK IS ABOUT RELEASE OF 1116 00:43:45,100 --> 00:43:47,236 PRINCIPLES OF COMMUNITY 1117 00:43:47,236 --> 00:43:48,604 ENGAGEMENT, THIS IS THE THIRD 1118 00:43:48,604 --> 00:43:49,872 EDITION OF THIS PIECE AND IT IS 1119 00:43:49,872 --> 00:43:51,407 A PRACTICAL GUIDE FOR COMMUNITY 1120 00:43:51,407 --> 00:43:55,144 ENGAGEMENT THAT'S WRITTEN BY THE 1121 00:43:55,144 --> 00:43:57,546 COMMUNITY OVER A 165 RENOWN 1122 00:43:57,546 --> 00:43:59,548 PRACTITIONERS AROUND THE 1123 00:43:59,548 --> 00:44:02,117 COUNTRY. ONE OF OUR COUNCIL 1124 00:44:02,117 --> 00:44:04,319 MEMBERS HAS BEEN ACTIVE AND 1125 00:44:04,319 --> 00:44:06,321 LEADING A LOT OF EFFORT SO I 1126 00:44:06,321 --> 00:44:08,257 WOULD LIKE TO THANK SERGIO FOR 1127 00:44:08,257 --> 00:44:10,092 HIS ROLE IN THIS AS WELL. SO H 1128 00:44:10,092 --> 00:44:11,226 IS JUST ANOTHER THING THAT I 1129 00:44:11,226 --> 00:44:14,363 THINK IS REALLY WHAT NCATS -- 1130 00:44:14,363 --> 00:44:15,397 WHY NCATS REMAINS IMPORTANT TO 1131 00:44:15,397 --> 00:44:19,535 THE WORK WE DO IN CLINICAL AND 1132 00:44:19,535 --> 00:44:21,637 TRANSLATIONAL SCIENCE. NEXT 1133 00:44:21,637 --> 00:44:22,638 SLIDE IS JUST UPDATE ON WHAT WE 1134 00:44:22,638 --> 00:44:26,108 HAVE BEEN DOING IN THE NATIONAL 1135 00:44:26,108 --> 00:44:30,345 CLINICAL COHORT COLLABORATIVE OR 1136 00:44:30,345 --> 00:44:34,983 NC 3. WE HAD A LONG STANDING 1137 00:44:34,983 --> 00:44:36,919 ENCLAVE IN THIS SPACE AROUND 1138 00:44:36,919 --> 00:44:38,954 COVID AND LONG COVID AND WE ARE 1139 00:44:38,954 --> 00:44:40,756 PARTICULARLY NOW SHIFTING TO THE 1140 00:44:40,756 --> 00:44:42,391 LONG COVID SPACE. BUT WE ARE 1141 00:44:42,391 --> 00:44:44,693 ALSO RECOGNIZING THE IMPORTANCE 1142 00:44:44,693 --> 00:44:47,429 AND VALUE OF REAL WORLD DATA AND 1143 00:44:47,429 --> 00:44:48,097 ELECTRONIC HEALTH RECORD 1144 00:44:48,097 --> 00:44:48,997 INFORMATION SO WE HAVE CONDUCTED 1145 00:44:48,997 --> 00:44:52,468 A SERIES OF PILOTS, USING OUR 1146 00:44:52,468 --> 00:44:53,068 ENCLAVE INFRASTRUCTURE TO 1147 00:44:53,068 --> 00:44:56,772 DEVELOP OTHER AREAS THAT WE CAN 1148 00:44:56,772 --> 00:44:57,806 PURSUE IN THE RESEARCH SPACE SO 1149 00:44:57,806 --> 00:45:00,776 WE HAVE A KIDNEY DISEASE ENCLAVE 1150 00:45:00,776 --> 00:45:01,810 AND CANCER ENCLAVE PILOT AS 1151 00:45:01,810 --> 00:45:05,180 WELL. BUT A KEY FEATURE IS 1152 00:45:05,180 --> 00:45:07,216 THERE IS A COMMON INFRASTRUCTURE 1153 00:45:07,216 --> 00:45:10,219 WITH THIS ENCLAVE. ON LEFT-HAND 1154 00:45:10,219 --> 00:45:11,787 SIDE OF THAT COMMON 1155 00:45:11,787 --> 00:45:12,988 INFRASTRUCTURE IS THAT THE WORK 1156 00:45:12,988 --> 00:45:14,490 WITHIN THE ENCLAVE CAN HAVE 1157 00:45:14,490 --> 00:45:19,895 ACCESS TO MANY OTHER TYPES OF 1158 00:45:19,895 --> 00:45:21,897 GOVERNANCE STRUCTURE, HELPING 1159 00:45:21,897 --> 00:45:23,966 DATA CLEAN, DATA QUALITY, HOW WE 1160 00:45:23,966 --> 00:45:29,037 DO DEIDENTIFICATION. AND AI AND 1161 00:45:29,037 --> 00:45:30,239 TOOL BASED ENVIRONMENT. 1162 00:45:30,239 --> 00:45:31,840 SO THAT COMMON INFRASTRUCTURE IS 1163 00:45:31,840 --> 00:45:35,611 APPLIED TO ANY GIVEN ENCLAVE 1164 00:45:35,611 --> 00:45:37,412 WITHIN OUR CLINICAL NEW 1165 00:45:37,412 --> 00:45:39,314 STRUCTURE. ANOTHER FEATURE ON 1166 00:45:39,314 --> 00:45:40,849 RIGHT HANDED SIDE ARE THE 1167 00:45:40,849 --> 00:45:42,284 RESEARCH DATA SETS. WE HAVE 1168 00:45:42,284 --> 00:45:44,586 BEEN ABLE TO BRING RESEARCH DATA 1169 00:45:44,586 --> 00:45:47,389 SETS THAT EXIST ELSEWHERE BUT WE 1170 00:45:47,389 --> 00:45:48,757 BROUGHT THEM TO MAKE THE WHOLE 1171 00:45:48,757 --> 00:45:50,359 OF THE RESEARCH DATA SETS 1172 00:45:50,359 --> 00:45:53,095 GREATER THAN THE SUM OF THE 1173 00:45:53,095 --> 00:45:56,198 PARTS. THE STRUCTURE OF THIS 1174 00:45:56,198 --> 00:45:57,533 ALLOWS US TO LEVERAGE THOSE 1175 00:45:57,533 --> 00:45:58,433 COMMON BITS OF INFRASTRUCTURE 1176 00:45:58,433 --> 00:46:01,003 THROUGH THE DATA SETS OR THE 1177 00:46:01,003 --> 00:46:02,671 GOVERNANCE OR WHATEVER THAT 1178 00:46:02,671 --> 00:46:04,840 MIGHT LOOK LIKE, KEEPS 1179 00:46:04,840 --> 00:46:05,874 SUSTAINABLE FOR MANY RESEARCH 1180 00:46:05,874 --> 00:46:06,775 QUESTIONS AND NEEDS. SO WE 1181 00:46:06,775 --> 00:46:08,677 DON'T HAVE TO RECREATE THE WHEEL 1182 00:46:08,677 --> 00:46:11,346 EACH TIME. INSTEAD WE THINK EACH 1183 00:46:11,346 --> 00:46:13,382 PARTICULAR RESEARCH QUESTION WE 1184 00:46:13,382 --> 00:46:14,316 ARE INTERESTED IN. SO I WANT TO 1185 00:46:14,316 --> 00:46:15,651 GIVE YOU A SENSE WHERE WE ARE 1186 00:46:15,651 --> 00:46:19,087 GOING NEXT WITH OUR ELECTRONIC 1187 00:46:19,087 --> 00:46:21,890 HEALTH RECORD DATABASE THROUGH 1188 00:46:21,890 --> 00:46:23,692 NC 3 CLINICAL. I ALSO WANTED TO 1189 00:46:23,692 --> 00:46:25,227 HIGHLIGHT THE REAL SUCCESS OF 1190 00:46:25,227 --> 00:46:26,662 WHAT'S HAPPENED IN THE COVID 1191 00:46:26,662 --> 00:46:29,531 SPACE FROM THE LAST FIVE YEARS 1192 00:46:29,531 --> 00:46:34,102 OF THIS WORK. REALLY INCREDIBLE 1193 00:46:34,102 --> 00:46:35,537 PRODUCTIVITY IN THIS TYPE OF 1194 00:46:35,537 --> 00:46:37,406 CLINICAL DATA RESEARCH THAT HAS 1195 00:46:37,406 --> 00:46:39,508 HELPED US THINK ABOUT THIS MORE 1196 00:46:39,508 --> 00:46:40,876 DEEPLY AND RECOGNIZE WE NEED TO 1197 00:46:40,876 --> 00:46:43,512 DO MORE OF THIS IN OTHER 1198 00:46:43,512 --> 00:46:45,047 DISEASES. WHAT WAS DONE IN COVID 1199 00:46:45,047 --> 00:46:46,915 IS LIKE A PROOF OF PRINCIPLE 1200 00:46:46,915 --> 00:46:48,517 THAT THIS NEEDS TO BE APPLIED 1201 00:46:48,517 --> 00:46:49,651 MORE BROADLY. SO I WANT TO GIVE 1202 00:46:49,651 --> 00:46:51,019 YOU A SENSE OF THE OTHER 1203 00:46:51,019 --> 00:46:52,921 ACTIVITIES THAT HAVE GONE ON IN 1204 00:46:52,921 --> 00:46:55,457 TERMS OF NOT JUST THE 1205 00:46:55,457 --> 00:46:57,159 PUBLICATIONS BUT COLLABORATION 1206 00:46:57,159 --> 00:46:59,494 INCENTIVE IT PROVIDES, THE 1207 00:46:59,494 --> 00:47:01,697 INFORMATION USED TO CHANGE 1208 00:47:01,697 --> 00:47:04,766 GUIDELINES AND HOW -- AND CARE. 1209 00:47:04,766 --> 00:47:07,002 EVIDENCE-BASED DEFINITIONS OF 1210 00:47:07,002 --> 00:47:08,470 PARTICULAR DISEASES LIKE LONG 1211 00:47:08,470 --> 00:47:10,906 COVID AND DEVELOPING NEW MODELS 1212 00:47:10,906 --> 00:47:12,441 FOR HOW THESE ARE STUDIED. SO H 1213 00:47:12,441 --> 00:47:14,943 IS REALLY A -- I THINK AGAIN 1214 00:47:14,943 --> 00:47:16,178 PROOF OF PRINCIPLE HOW IMPORTANT 1215 00:47:16,178 --> 00:47:17,779 THIS WORK IS FOR OTHER DISEASES 1216 00:47:17,779 --> 00:47:20,816 AS WELL. THE NEXT SLIDE I JUST 1217 00:47:20,816 --> 00:47:25,287 TALK ABOUT WHAT'S NEXT FOR NC 3 1218 00:47:25,287 --> 00:47:27,990 CLINICAL. BASICALLY WHAT IS NEXT 1219 00:47:27,990 --> 00:47:29,891 IS WE WANT TO CONTINUE TO 1220 00:47:29,891 --> 00:47:31,226 DEVELOP THESE PILOTS AND 1221 00:47:31,226 --> 00:47:33,929 HOPEFULLY EXPAND THEM INTO THESE 1222 00:47:33,929 --> 00:47:35,364 OTHER AREAS. WE ARE WORKING 1223 00:47:35,364 --> 00:47:36,398 THROUGH THE OPERATIONAL 1224 00:47:36,398 --> 00:47:37,733 APPROACHES AND THE GOVERNANCE 1225 00:47:37,733 --> 00:47:39,067 STRUCTURE AN TECHNICAL 1226 00:47:39,067 --> 00:47:40,068 ARCHITECTURE THAT IS NEEDED TO 1227 00:47:40,068 --> 00:47:42,838 DO THAT. SO WE ARE CONTINUING TO 1228 00:47:42,838 --> 00:47:46,241 HAVE EVERYTHING AVAILABLE TO THE 1229 00:47:46,241 --> 00:47:47,509 RESEARCH COMMUNITY BUT ALSO 1230 00:47:47,509 --> 00:47:49,278 USING THIS PILOT PHASE FOR THOSE 1231 00:47:49,278 --> 00:47:50,746 OTHER AREAS OF RESEARCH 1232 00:47:50,746 --> 00:47:51,546 QUESTIONS WE WOULD LIKE TO 1233 00:47:51,546 --> 00:47:56,218 PURSUE STUDY. ONE MORE THING I 1234 00:47:56,218 --> 00:47:58,186 WANT TO MENTION IN TERMS OF 1235 00:47:58,186 --> 00:47:59,955 ACTIVITIES THAT NCATS -- 1236 00:47:59,955 --> 00:48:01,823 ACTUALLY TWO THINGS, IN TERMS OF 1237 00:48:01,823 --> 00:48:04,259 NCATS WHAT NCATS IS DOING IN 1238 00:48:04,259 --> 00:48:06,528 PURSUING. ONE IS IN THE NEXT 1239 00:48:06,528 --> 00:48:10,265 SLIDE OF QUANTUM SENSING AND 1240 00:48:10,265 --> 00:48:13,568 QUANTUM COMPUTING. AND APOLOGIES 1241 00:48:13,568 --> 00:48:15,837 FOR THESE SLIDES BEING A LITTLE 1242 00:48:15,837 --> 00:48:17,139 BIT CHANGED IN HOW THEY WERE 1243 00:48:17,139 --> 00:48:20,108 BROUGHT INTO THE FRAMEWORK BUT 1244 00:48:20,108 --> 00:48:21,777 HOPEFULLY YOU CAN SEE THIS 1245 00:48:21,777 --> 00:48:25,847 RELATIVELY WELL. WE HAVE 1246 00:48:25,847 --> 00:48:28,283 LAUNCHED A PRIZE CHALLENGE OR 1247 00:48:28,283 --> 00:48:31,386 PRICE COMPETITION TO CATALYZE 1248 00:48:31,386 --> 00:48:32,287 APPLICATIONS OF QUANTUM 1249 00:48:32,287 --> 00:48:34,189 COMPUTING AND QUANTUM SENSING 1250 00:48:34,189 --> 00:48:35,524 THROUGH A VARIETY OF 1251 00:48:35,524 --> 00:48:36,291 MULTI-DISCIPLINARY EFFORTS SO 1252 00:48:36,291 --> 00:48:39,161 THE PRIZE IS PARTICULARLY MEANT 1253 00:48:39,161 --> 00:48:43,065 TO DERISK THIS AS AN AREA OF 1254 00:48:43,065 --> 00:48:44,499 SCIENCE FOR HOW WE WANT TO BRING 1255 00:48:44,499 --> 00:48:47,502 IN MORE BIOMEDICAL RESEARCH 1256 00:48:47,502 --> 00:48:49,137 QUESTIONS. IN QUANTUM COMPUTING 1257 00:48:49,137 --> 00:48:54,843 AND SENSING. THESE TWO 1258 00:48:54,843 --> 00:48:57,746 ACTIVITIES ARE AROUNDLY FOR 1259 00:48:57,746 --> 00:48:59,414 QUANTUM COMPUTING AROUND DRUG 1260 00:48:59,414 --> 00:49:01,650 DISCOVERY, DEVELOPING MACHINE 1261 00:49:01,650 --> 00:49:02,984 ALGORITHMS AND QUANTUM SENSING 1262 00:49:02,984 --> 00:49:04,820 HOW WE APPLY THOSE APPROACHES TO 1263 00:49:04,820 --> 00:49:06,488 ADVANCING BIOMEDICAL 1264 00:49:06,488 --> 00:49:08,357 APPLICATIONS. THINKING ABOUT 1265 00:49:08,357 --> 00:49:09,958 NOVEL APPROACH METHODOLOGIES AND 1266 00:49:09,958 --> 00:49:15,263 EMBEDDING SENSORS OR DIAGNOSTICS 1267 00:49:15,263 --> 00:49:16,631 SO THERE IS GREAT ACTIVITY GOING 1268 00:49:16,631 --> 00:49:17,766 ON IN THIS SPACE AND WE ARE 1269 00:49:17,766 --> 00:49:22,337 EXCITED THAT THIS IS MOVING 1270 00:49:22,337 --> 00:49:26,475 FORWARD TOWARDS THE REVIEW STAGE 1271 00:49:26,475 --> 00:49:31,246 RELATIVELY SOON. IN FACT MAY 1272 00:49:31,246 --> 00:49:33,215 THROUGH JULY WILL BE THAT STAGE 1273 00:49:33,215 --> 00:49:35,917 1 WHEN WE'LL SEE THAT. WITH THIS 1274 00:49:35,917 --> 00:49:37,486 TOO THERE IS A SHARED INTEREST 1275 00:49:37,486 --> 00:49:38,720 ACROSS THE NIH PARTNERING WITH 1276 00:49:38,720 --> 00:49:40,956 OTHER INSTITUTES AND CENTERS. 1277 00:49:40,956 --> 00:49:42,090 EVERYTHING IS A TEAM WITH US SO 1278 00:49:42,090 --> 00:49:45,293 WE DO THAT IN IWAY BUT WE ARE 1279 00:49:45,293 --> 00:49:46,561 EXCITED TO HAVE THE NATIONAL EYE 1280 00:49:46,561 --> 00:49:47,829 INSTITUTE, ENGINEERING INSTITUTE 1281 00:49:47,829 --> 00:49:52,033 AND IDIB ENGINEERING AND IMAGING 1282 00:49:52,033 --> 00:49:54,269 DATA SCIENCE AND THE CENTER FOR 1283 00:49:54,269 --> 00:49:57,572 IT AS WELL. I WILL ALSO 1284 00:49:57,572 --> 00:49:58,473 RECOGNIZE (INDISCERNIBLE), 1285 00:49:58,473 --> 00:50:00,809 DEPUTY DIRECTORRER OF OFFICE OF 1286 00:50:00,809 --> 00:50:02,811 SPECIAL INITIATIVES IN DAN 1287 00:50:02,811 --> 00:50:04,846 TAGLY'S GROUP AND SHE SPEARHEAD 1288 00:50:04,846 --> 00:50:06,415 THIRD DEGREE ENTIRE EFFORT NOT 1289 00:50:06,415 --> 00:50:09,384 JUST AT NCATS BUT ACROSS THE 1290 00:50:09,384 --> 00:50:11,253 ENTIRE NIH SO GRATEFUL FOR HER 1291 00:50:11,253 --> 00:50:13,355 LEADERSHIP THERE. ONE OTHER AREA 1292 00:50:13,355 --> 00:50:16,425 WE HAVE LAUNCHED IS ALSO ONE 1293 00:50:16,425 --> 00:50:17,859 THAT'S QUITE EXCITING BECAUSE IT 1294 00:50:17,859 --> 00:50:19,327 IS THROUGH THE COMMON FUND 1295 00:50:19,327 --> 00:50:21,696 VENTURE PROGRAM. I BROUGHT IT UP 1296 00:50:21,696 --> 00:50:23,598 AT THE LAST COUNCIL MEETING SO I 1297 00:50:23,598 --> 00:50:24,733 WON'T SPEND MUCH TIME ON THIS 1298 00:50:24,733 --> 00:50:26,601 BUT THE NEWBORN SCREENING 1299 00:50:26,601 --> 00:50:30,539 THROUGH WHOLE GENOME SEQUENCING 1300 00:50:30,539 --> 00:50:31,973 COLLABORATORY HAS NOW LAUNCHED. 1301 00:50:31,973 --> 00:50:33,642 THERE ARE ANNOUNCEMENTS ON THE 1302 00:50:33,642 --> 00:50:35,877 STREET AND WE ARE LOOKING TO 1303 00:50:35,877 --> 00:50:38,847 HAVE A BUDGET OF 4.8 MILLION 1304 00:50:38,847 --> 00:50:40,749 TOTAL COST PER YEAR FOR ONE 1305 00:50:40,749 --> 00:50:41,883 MERITORIOUS TRANSACTION AWARD 1306 00:50:41,883 --> 00:50:43,585 THAT WILL BE A THREE YEAR 1307 00:50:43,585 --> 00:50:45,454 PROJECT. WE HOPE THAT WILL 1308 00:50:45,454 --> 00:50:47,022 DEMONSTRATE THE FEASIBILITY OF 1309 00:50:47,022 --> 00:50:48,356 ADDING WHOLE GENOME SEQUENCING 1310 00:50:48,356 --> 00:50:52,894 TO AN EXISTING PUBLIC HEALTH 1311 00:50:52,894 --> 00:50:58,233 RESOURCE. PERHAPS STARTING WITH 1312 00:50:58,233 --> 00:50:59,401 5 AND 10 SATE WITH DIFFERENT 1313 00:50:59,401 --> 00:51:00,769 LEVELS EXPERIENCE WITH NIH 1314 00:51:00,769 --> 00:51:02,437 FUNDED RESEARCH OR WHOLE GENOME 1315 00:51:02,437 --> 00:51:03,672 SEQUENCING AND THEN CONDUCT 1316 00:51:03,672 --> 00:51:05,574 THESE IN AN EMBEDDED RESEARCH 1317 00:51:05,574 --> 00:51:07,342 STUDY AND GENERATE A FINAL 1318 00:51:07,342 --> 00:51:08,810 REPORT OF HOW THAT FEASIBILITY 1319 00:51:08,810 --> 00:51:10,178 IS GOING SO WE CAN THINK ABOUT 1320 00:51:10,178 --> 00:51:13,048 USING THIS AS THE VENTURE 1321 00:51:13,048 --> 00:51:14,716 INITIATIVE AND EXPAND THIS INTO 1322 00:51:14,716 --> 00:51:17,285 A BROADER INITIATIVE. HOPEFULLY 1323 00:51:17,285 --> 00:51:18,987 WE WILL BE SUCCESSFUL IN DOING 1324 00:51:18,987 --> 00:51:20,455 THIS BUT I WANT TO RELAY TO YOU 1325 00:51:20,455 --> 00:51:25,961 THIS IS NOW LAUNCHED. THE NEXT 1326 00:51:25,961 --> 00:51:26,895 SLIDE THESE THE STRUCTURE OF THE 1327 00:51:26,895 --> 00:51:28,997 PROGRAM AND THE FOLKS WHO ARE 1328 00:51:28,997 --> 00:51:31,066 CRITICAL AND THE SUCCESS. THIS 1329 00:51:31,066 --> 00:51:36,371 IS PARTNERSHIP WITH NHGRI WITH 1330 00:51:36,371 --> 00:51:39,374 NICHD AND WITH NCATS. THESE ARE 1331 00:51:39,374 --> 00:51:41,543 LEADER SHOWN HERE WHO ARE 1332 00:51:41,543 --> 00:51:43,979 DRIVING THIS PARTICULAR 1333 00:51:43,979 --> 00:51:51,019 INITIATIVE. NOW, THIS NEXT 1334 00:51:51,019 --> 00:51:52,921 SECTION IS, THAT SECTION 1335 00:51:52,921 --> 00:51:54,990 CONCLUDES THE DIRECTOR'S REPORT 1336 00:51:54,990 --> 00:51:57,726 PER SE. NOW WE WANT TO SPEND 1337 00:51:57,726 --> 00:52:01,129 ABOUT TEN MINUTES OR SO ON 1338 00:52:01,129 --> 00:52:03,665 ANOTHER SECTION I AM PRESENTING 1339 00:52:03,665 --> 00:52:06,334 TODAY AS, THIS IS SORT OF A 1340 00:52:06,334 --> 00:52:07,369 MANDATORY REQUIREMENT THE IC 1341 00:52:07,369 --> 00:52:08,937 DIRECTOR PRESENT THIS 1342 00:52:08,937 --> 00:52:11,473 INFORMATION TO OUR COUNCIL. H IS 1343 00:52:11,473 --> 00:52:16,077 THE NCATS TRIENNIAL REPORT TO 1344 00:52:16,077 --> 00:52:17,345 MONITORING ADHERENCE TO NIH 1345 00:52:17,345 --> 00:52:19,014 POLICY ON INCLUSION OF WOMEN AN 1346 00:52:19,014 --> 00:52:22,551 MINMINORITIES IN CLINICAL RESEA. 1347 00:52:22,551 --> 00:52:24,786 WE DO IT EVERYONE THREE YEARS, I 1348 00:52:24,786 --> 00:52:29,491 WANT TO THANK MUNZIBA KHAN AS 1349 00:52:29,491 --> 00:52:32,427 WELL AS JOSH TO PRESENT IT TO 1350 00:52:32,427 --> 00:52:34,863 YOU TODAY. SO THE NEXT SLIDE IS 1351 00:52:34,863 --> 00:52:36,765 JUST REALLY SHOWING THAT THIS IS 1352 00:52:36,765 --> 00:52:39,601 MANDATED BY THE PUBLIC HEALTH 1353 00:52:39,601 --> 00:52:44,906 SERVICE ACT SECTION 492B, 42 1354 00:52:44,906 --> 00:52:46,408 UNITED STATES CODE SECTION 289A 1355 00:52:46,408 --> 00:52:48,343 2 THAT ENSURING THE INCLUSION OF 1356 00:52:48,343 --> 00:52:50,278 WOMEN AND MEMBERS OF RACIAL 1357 00:52:50,278 --> 00:52:51,980 ETHNIC MINORITY GROUPS IN ALL 1358 00:52:51,980 --> 00:52:53,615 NIH FUNDED CLINICAL RESEARCH IN 1359 00:52:53,615 --> 00:52:58,086 A MANNER THAT IS APPROPRIATE TO 1360 00:52:58,086 --> 00:53:01,323 TTOSCIENTIFIC QUESTION UNDER ST. 1361 00:53:01,323 --> 00:53:03,358 THE OER AT THE HIPPOREQUIRES 1362 00:53:03,358 --> 00:53:05,260 CERTIFICATION BY THE IC 1363 00:53:05,260 --> 00:53:07,796 DIRECTORS FOR THIS. AND WE 1364 00:53:07,796 --> 00:53:09,464 CERTIFY THE DATA ARE ACCEPTABLE 1365 00:53:09,464 --> 00:53:11,600 FOR INCLUSION IN THIS REPORT. 1366 00:53:11,600 --> 00:53:13,802 AND THAT THE DATA REFLECT THE 1367 00:53:13,802 --> 00:53:15,070 INFORMATION COLLECTED AS OF THE 1368 00:53:15,070 --> 00:53:18,406 DATE THE REPORT WAS RUN AND ONE 1369 00:53:18,406 --> 00:53:20,375 THING I WILL NOTE HERE IS THAT 1370 00:53:20,375 --> 00:53:22,611 WE ARE UNABLE TO GO BACK AND 1371 00:53:22,611 --> 00:53:23,979 CHANGE THINGS WITHIN THE REPORT 1372 00:53:23,979 --> 00:53:25,780 IF THEY EXIST IS WE CAN'T GO 1373 00:53:25,780 --> 00:53:27,015 BACK AND CORRECT MISTAKES BUT WE 1374 00:53:27,015 --> 00:53:28,416 CAN MAKE SURE THOSE MISTAKES ARE 1375 00:53:28,416 --> 00:53:30,418 I CAN PED UP IN ANY DATA THAT IS 1376 00:53:30,418 --> 00:53:32,621 MOVING FORWARD. SOMETIMES WE DO 1377 00:53:32,621 --> 00:53:34,255 FIND THOSE MISTAKES AND THEY 1378 00:53:34,255 --> 00:53:35,457 MAKE A BIG DIFFERENCE IN THE 1379 00:53:35,457 --> 00:53:40,929 TABLES. SO IT IS VERY DIFFICULT 1380 00:53:40,929 --> 00:53:42,631 TO EXPLAIN THAT WE CAN'T CHANGE 1381 00:53:42,631 --> 00:53:44,065 THAT BUT WE DO USE IT TO MAKE 1382 00:53:44,065 --> 00:53:46,067 SURE WE DON'T MAKE THOSE SAME 1383 00:53:46,067 --> 00:53:47,335 MISTAKES MOVING FORWARD. I ALSO 1384 00:53:47,335 --> 00:53:48,903 WANT TO SAY HERE THAT THE 1385 00:53:48,903 --> 00:53:50,639 MAJORITY OF NCATS SUPPORTED 1386 00:53:50,639 --> 00:53:53,942 CLINICAL RESEARCH TAKES THE FORM 1387 00:53:53,942 --> 00:53:57,479 OF FORMAL PARTNERSHIPS WITH 1388 00:53:57,479 --> 00:53:59,347 OTHER NIH INSTITUTES AND 1389 00:53:59,347 --> 00:54:01,516 CENTERS. TO AVOID DUPLICATION OF 1390 00:54:01,516 --> 00:54:04,252 REPORTING THE PARTNERING IC WE 1391 00:54:04,252 --> 00:54:09,824 WORK WITH NOT NCATS, REPORTS THE 1392 00:54:09,824 --> 00:54:12,594 INCLUSION ENROLLMENT DATA SO 1393 00:54:12,594 --> 00:54:13,962 MIGHT THINK THE NUMBERS ARE 1394 00:54:13,962 --> 00:54:15,597 FAIRLY LOW FOR NCATS. IF U YOU 1395 00:54:15,597 --> 00:54:18,033 I THIS IT IS LARGELY BECAUSE 1396 00:54:18,033 --> 00:54:19,367 THOSE NUMBERS ARE REPORTED WITH 1397 00:54:19,367 --> 00:54:20,602 PARTNERING ICs DOING CLINICAL 1398 00:54:20,602 --> 00:54:22,937 TRIALS AS WELL. SO NCATS 1399 00:54:22,937 --> 00:54:26,041 NUMBERS ARE A LITTLE MODEST. BUT 1400 00:54:26,041 --> 00:54:28,610 EXAMPLES OF NIH AND NCATS 1401 00:54:28,610 --> 00:54:30,612 PROGRAMS FOR WHICH OTHER ICs 1402 00:54:30,612 --> 00:54:32,814 REPORT ENROLLMENT DATA 1403 00:54:32,814 --> 00:54:35,050 ESSENTIALLY ON OUR BEHALF ARE 1404 00:54:35,050 --> 00:54:38,787 THINGS LIKE THE HEAL PROGRAM OR 1405 00:54:38,787 --> 00:54:42,791 HELPING END ADDICTION LONG TERM, 1406 00:54:42,791 --> 00:54:45,226 THE NETWORK AND OTHER PARTNERS 1407 00:54:45,226 --> 00:54:46,327 AND RARE DISEASE CLINICAL 1408 00:54:46,327 --> 00:54:48,129 RESEARCH NETWORK SUPPORTED BY 1409 00:54:48,129 --> 00:54:49,698 OTHER ICs AS WELL THAT TAKE ON 1410 00:54:49,698 --> 00:54:53,501 THAT RESPONSIBILITY. EXAMPLES OF 1411 00:54:53,501 --> 00:54:55,570 NCATS PROGRAMS FOR WHICH OUR 1412 00:54:55,570 --> 00:54:58,039 ENROLLMENT DATA ARE REPORTED ARE 1413 00:54:58,039 --> 00:54:59,774 THINGS LIKE OUR COLLABORATIVE 1414 00:54:59,774 --> 00:55:02,343 INNOVATION AWARDS THROUGH THE 1415 00:55:02,343 --> 00:55:03,578 CTSA PROGRAM OR OUR SMALL 1416 00:55:03,578 --> 00:55:05,714 BUSINESS AWARDS OR CTSA PILOT 1417 00:55:05,714 --> 00:55:07,248 STUDIES. SO THAT'S -- THOSE ARE 1418 00:55:07,248 --> 00:55:08,349 THE KINDS OF NUMBERS YOU WILL 1419 00:55:08,349 --> 00:55:10,185 SEE REFLECTED IN THE TABLES THAT 1420 00:55:10,185 --> 00:55:12,187 I'M ABOUT TO SHOW YOU. AGAIN, 1421 00:55:12,187 --> 00:55:13,855 THIS IS A REQUIREMENT FOR US TO 1422 00:55:13,855 --> 00:55:15,690 SHARE WITH YOU THESE PARTICULAR 1423 00:55:15,690 --> 00:55:22,464 DATA. YOU CAN SEE BROADER 1424 00:55:22,464 --> 00:55:25,233 NUMBERS HERE 22-24 COVERING 1425 00:55:25,233 --> 00:55:27,802 THREE YEARS, THESE ARE HUMAN 1426 00:55:27,802 --> 00:55:30,271 SUBJECTS AWARDS BY FISCAL YEAR. 1427 00:55:30,271 --> 00:55:32,307 SO THE NUMBER OF AWARDS IN 2022 1428 00:55:32,307 --> 00:55:34,175 WERE MUCH HIGHER THAN THEY ARE 1429 00:55:34,175 --> 00:55:36,511 IN 2024, LIKELY BECAUSE OF THE 1430 00:55:36,511 --> 00:55:38,513 NUMBER OF CLINICAL TRIALS 1431 00:55:38,513 --> 00:55:40,882 CONDUCTED DURING THE PANDEMIC. I 1432 00:55:40,882 --> 00:55:43,284 THINK THAT ACCOUNTS FOR A LOT OF 1433 00:55:43,284 --> 00:55:45,754 THIS DISCREPANCY ACROSS. SO THIS 1434 00:55:45,754 --> 00:55:47,155 WILL START TO PROBABLY LEVEL OUT 1435 00:55:47,155 --> 00:55:49,257 IN THE NEXT SERIES OF INCLUSION 1436 00:55:49,257 --> 00:55:52,160 REPORT IN THREE YEARS. THE NEXT 1437 00:55:52,160 --> 00:55:55,029 SLIDE AGAIN MAKES THIS CASE 1438 00:55:55,029 --> 00:55:59,234 ABOUT THE FADES 3 LIMITATION 1439 00:55:59,234 --> 00:56:02,203 NCATS CAN SUPPORT PHASE 3 1440 00:56:02,203 --> 00:56:03,671 CLINICAL TRIALS WITH RARE 1441 00:56:03,671 --> 00:56:05,540 EXCEPTIONS FOR THOSE. YOU WILL 1442 00:56:05,540 --> 00:56:07,776 SEE IN THE INCLUSION AND DATA 1443 00:56:07,776 --> 00:56:10,879 RECORD HERE, THIS IS ABOUT PHASE 1444 00:56:10,879 --> 00:56:13,748 3 TRIALS. YOU WILL SEE A 1 HERE. 1445 00:56:13,748 --> 00:56:17,318 THAT 1 IS REFLECTIVE OF OUR ROLE 1446 00:56:17,318 --> 00:56:20,855 IN THE COVID-19 PANDEMIC THROUGH 1447 00:56:20,855 --> 00:56:23,825 ACTIVE PROGRAM. WE WERE MANAGERS 1448 00:56:23,825 --> 00:56:26,361 OF ACTIVE 6. THIS IS ONE OF THE 1449 00:56:26,361 --> 00:56:27,395 THOSE CLINICAL TRIALS WE FUND 1450 00:56:27,395 --> 00:56:28,429 THROUGH THE ACTIVE PROGRAM. SO 1451 00:56:28,429 --> 00:56:30,598 IT WAS NOT NCATS DOLLARS THAT 1452 00:56:30,598 --> 00:56:32,467 SUPPORTED THIS, THIS WAS THROUGH 1453 00:56:32,467 --> 00:56:34,502 THE ACTIV PROGRAM, THAT IS WHY 1454 00:56:34,502 --> 00:56:38,439 IT IS REPPED HERE ON OUR BEHALF. 1455 00:56:38,439 --> 00:56:39,374 -- REPRESENTED HERE ON OUR 1456 00:56:39,374 --> 00:56:41,242 BEHALF. THAT'S WHAT THAT NUMBER 1457 00:56:41,242 --> 00:56:42,477 MEANS, NEXT SLIDE WE LOOK AT THE 1458 00:56:42,477 --> 00:56:43,912 BREAK DOWN. THIS IS -- YOU DON'T 1459 00:56:43,912 --> 00:56:45,580 HAVE TO LOOK AT THIS SLIDE, I 1460 00:56:45,580 --> 00:56:47,048 WILL BREAK IT DOWN FOR YOU, BUT 1461 00:56:47,048 --> 00:56:50,752 THIS IS TOTAL SLIDE WE HAVE IN 1462 00:56:50,752 --> 00:56:53,354 TERMS OF THE SEX BY RACE 1463 00:56:53,354 --> 00:56:56,891 ETHNICITY FOR EACH OF THESE 1464 00:56:56,891 --> 00:56:58,660 YEARS IN THE NIH DEFINED 1465 00:56:58,660 --> 00:57:01,563 CLINICAL RESEARCH AREAS. IF YOU 1466 00:57:01,563 --> 00:57:04,532 GO TO THE NEXT SLIDE WE BREAK IT 1467 00:57:04,532 --> 00:57:06,534 DOWN SO SALIENT POINTS ARE HERE. 1468 00:57:06,534 --> 00:57:08,670 LOOK ACROSS THE DIFFERENT YEARS 1469 00:57:08,670 --> 00:57:11,005 BROKEN DOWN BY FEMALE, MALE AND 1470 00:57:11,005 --> 00:57:14,008 UNKNOWN, AND MINORITY STATUS OF 1471 00:57:14,008 --> 00:57:15,877 THESE AS REPORTED, THE PERCENT 1472 00:57:15,877 --> 00:57:18,213 OF MINORITY ENROLLEES REMAIN 1473 00:57:18,213 --> 00:57:20,348 CONSTANT FOR FEMALES AN MALES IN 1474 00:57:20,348 --> 00:57:23,351 22 AND 23, HOVER WE NOTICED 1475 00:57:23,351 --> 00:57:24,619 INCREASE IN FEMALE MINORITY 1476 00:57:24,619 --> 00:57:27,922 PARTICIPANTS IN 2024. SO THAT IS 1477 00:57:27,922 --> 00:57:31,326 ONE OF THOSE THINGS WE FOUND. ON 1478 00:57:31,326 --> 00:57:35,530 THE NEXT SLIDE AGAIN BROKEN DOWN 1479 00:57:35,530 --> 00:57:37,465 BY SEX RACEETH IN IS THE I A 1480 00:57:37,465 --> 00:57:39,133 CROSS THESE YEARS. ONE 1481 00:57:39,133 --> 00:57:41,469 PARTICULAR AREA WE SAW THAT 1482 00:57:41,469 --> 00:57:44,239 STUCK OUT WAS PERCENTAGE OF 1483 00:57:44,239 --> 00:57:46,574 HISPANIC LATINO ENROLLEES THAT 1484 00:57:46,574 --> 00:57:48,877 DECREASED DRAMATICALLY MANY 2023 1485 00:57:48,877 --> 00:57:52,113 BUT REMAINED CLOSE TO 40% FEMALE 1486 00:57:52,113 --> 00:57:55,316 ENROLLEES IN 2022 AND 2024. SO 1487 00:57:55,316 --> 00:57:57,952 THIS IS ONE AREA THAT HELPS US 1488 00:57:57,952 --> 00:57:58,987 WANT TO UNDERSTAND MORE ABOUT 1489 00:57:58,987 --> 00:58:00,455 WHY THAT IS. AND MAKE SURE WE 1490 00:58:00,455 --> 00:58:03,258 ARE ADDRESSING THIS MOVING 1491 00:58:03,258 --> 00:58:04,659 FORWARD. THAT IS ONE WAY WE 1492 00:58:04,659 --> 00:58:08,763 EVALUATE THESE DATA. SO GO TO 1493 00:58:08,763 --> 00:58:11,299 NEXT SLIDE, THOSE ARE THE UPSHOT 1494 00:58:11,299 --> 00:58:13,001 OF THIS PARTICULAR INCLUSION 1495 00:58:13,001 --> 00:58:15,236 REPORT FOR THIS TRIENNIAL DATA 1496 00:58:15,236 --> 00:58:17,272 ANALYSIS. THERE ARE THREE TAKE 1497 00:58:17,272 --> 00:58:19,073 AWAYS FOR US. ONE TO CONTINUE 1498 00:58:19,073 --> 00:58:22,210 TO GROW AND ENHANCE THE NCATS 1499 00:58:22,210 --> 00:58:23,845 COMMUNITY OF PRACTICE OF 1500 00:58:23,845 --> 00:58:25,747 INCLUSION AND MONITORING 1501 00:58:25,747 --> 00:58:27,181 ACTIVITIES BECAUSE AS WE LOOK AT 1502 00:58:27,181 --> 00:58:28,316 THESE DATA WE CAN MAKE 1503 00:58:28,316 --> 00:58:30,318 ADJUSTMENTS MOVING FORWARD. WE 1504 00:58:30,318 --> 00:58:31,352 WANT TO HIGHLIGHT AND SUPPORT 1505 00:58:31,352 --> 00:58:34,322 THE ROLE OF THE INCLUSION OF THE 1506 00:58:34,322 --> 00:58:35,356 BROAD RANGE OF PARTICIPANTS IN 1507 00:58:35,356 --> 00:58:36,891 RESEARCH AND THIS IS SOMETHING 1508 00:58:36,891 --> 00:58:39,093 THAT WE HAVE HIGHLIGHTED IN OUR 1509 00:58:39,093 --> 00:58:39,827 STREAK PLAN AND ITS 1510 00:58:39,827 --> 00:58:40,528 IMPLEMENTATION AND THAT IS 1511 00:58:40,528 --> 00:58:42,196 SOMETHING WE ARE VERY PASSIONATE 1512 00:58:42,196 --> 00:58:45,767 ABOUT AS WELL. THIRDLY WE WANT 1513 00:58:45,767 --> 00:58:49,170 TO AMPLIFY OUR EXISTING AND NEW 1514 00:58:49,170 --> 00:58:51,072 TRAINING OPPORTUNITIES FOR 1515 00:58:51,072 --> 00:58:54,575 ENSURING WE DESIGN TRIALS 1516 00:58:54,575 --> 00:58:56,044 AFFECTIVELY FOR INCLUSION 1517 00:58:56,044 --> 00:58:58,713 POLICIES AND PRACTICES. DESIGN 1518 00:58:58,713 --> 00:59:00,715 MEANS REALLY THINKING ABOUT THIS 1519 00:59:00,715 --> 00:59:02,750 IN ALL AREAS FROM SHORT TERM 1520 00:59:02,750 --> 00:59:04,385 STUDIES OR PILOTS ALL THE WAY 1521 00:59:04,385 --> 00:59:06,554 THROUGH REALLY BIG CLINICAL 1522 00:59:06,554 --> 00:59:11,292 TRIALS. SO THINKING HOW WE 1523 00:59:11,292 --> 00:59:12,160 INCORPORATE THAT THINKING IN THE 1524 00:59:12,160 --> 00:59:13,161 BEGINNING WE WANT TO DRIVE THAT 1525 00:59:13,161 --> 00:59:16,431 MORE TO ENHANCE THE RESULTS AS 1526 00:59:16,431 --> 00:59:19,200 WE MOVE FORWARD AND MAKE THE 1527 00:59:19,200 --> 00:59:22,670 TRIALS AS ROBUST AND RESULTS 1528 00:59:22,670 --> 00:59:24,572 DRIVEN AS POSSIBLE TO HELP 1529 00:59:24,572 --> 00:59:25,740 CHANGE AND IMPACT POPULATIONS 1530 00:59:25,740 --> 00:59:27,842 THAT ARE AFFECTED BY DISEASE. 1531 00:59:27,842 --> 00:59:29,744 THOSE ARE THE THREE TAKE AWAYS 1532 00:59:29,744 --> 00:59:36,384 FROM OUR TRIENNIAL REPORT. WHAT 1533 00:59:36,384 --> 00:59:39,954 I WILL ASK YOU IS ESSENTIALLY I 1534 00:59:39,954 --> 00:59:41,756 WILL CERTIFY THIS REPORT AND 1535 00:59:41,756 --> 00:59:45,193 JUST WANT TO MAKE SURE YOU ARE 1536 00:59:45,193 --> 00:59:46,294 AWARE OF THIS REPORT. IF YOU 1537 00:59:46,294 --> 00:59:48,429 HAVE ANY INPUT I WOULD LIKE THE 1538 00:59:48,429 --> 00:59:50,298 ASK YOU TO JUST HAVE -- IF YOU 1539 00:59:50,298 --> 00:59:52,133 HAVE ANY IDEAS HOW WE CAN 1540 00:59:52,133 --> 00:59:53,534 PERHAPS DO THIS BETTER WE WOULD 1541 00:59:53,534 --> 00:59:56,037 LOVE TO HEAR YOUR THOUGHTSES AND 1542 00:59:56,037 --> 00:59:57,605 YOUR INPUT ON THAT. THAT WILL 1543 00:59:57,605 --> 01:00:02,377 HELP US MOVE FORWARD. I THINK I 1544 01:00:02,377 --> 01:00:03,544 JUST HAVE ONE MORE POINT TO 1545 01:00:03,544 --> 01:00:07,415 RELAY. THIS IS ALSO PICKING UP 1546 01:00:07,415 --> 01:00:09,217 FROM OUR LAST COUNCIL MEETING. 1547 01:00:09,217 --> 01:00:14,422 GO TO THE NEXT SLIDE. WE -- WHAT 1548 01:00:14,422 --> 01:00:16,090 WE DO TYPICALLY IS IF ANYONE 1549 01:00:16,090 --> 01:00:17,692 WRITES A LETTER TO OUR COUNCIL 1550 01:00:17,692 --> 01:00:22,063 OR TO ME PERMLY, AND TO ME 1551 01:00:22,063 --> 01:00:24,632 PERSONALLY THAT ASKS ME RELATE 1552 01:00:24,632 --> 01:00:25,733 TO OUR COUNCIL THIS IS MY 1553 01:00:25,733 --> 01:00:27,535 OPPORTUNITY TO DO THAT IN OPEN 1554 01:00:27,535 --> 01:00:28,669 SESSION. WE RECEIVED A LETTER 1555 01:00:28,669 --> 01:00:31,906 FROM THE PHYSICIAN COMMUNITY, 1556 01:00:31,906 --> 01:00:32,673 PHYSICIAN COMMITTEE FOR 1557 01:00:32,673 --> 01:00:36,577 RESPONSIBLE MEDICINE. I WANT TO 1558 01:00:36,577 --> 01:00:39,013 THANK HEM FOR THEIR INPUT, WE 1559 01:00:39,013 --> 01:00:40,248 CAN MAKE THIS AVAILABLE UPON 1560 01:00:40,248 --> 01:00:43,818 REQUEST. BUT IT LARGELY TALKS 1561 01:00:43,818 --> 01:00:44,952 ABOUT THE ENTHUSIASTIC SUPPORT 1562 01:00:44,952 --> 01:00:48,156 FOR ELEVATING NCATS FROM A 1563 01:00:48,156 --> 01:00:49,857 CENTER TO AN INSTITUTE. THIS WAS 1564 01:00:49,857 --> 01:00:51,092 SOMETHING THAT CAME UP AT THE 1565 01:00:51,092 --> 01:00:52,994 LAST COUNCIL MEETING AND IF YOU 1566 01:00:52,994 --> 01:00:58,833 GO TO NEXT SLIDE I WANTED TO 1567 01:00:58,833 --> 01:01:00,735 THANK -- UPDATE YOU ON THIS 1568 01:01:00,735 --> 01:01:02,503 PROCESS. BECAUSE LAST MEET THE 1569 01:01:02,503 --> 01:01:03,671 COUNCIL MEMBERS PRESENTED ME 1570 01:01:03,671 --> 01:01:05,239 WITH A LETTER. ALSO IN SUPPORT 1571 01:01:05,239 --> 01:01:07,909 OF TRANSITIONING FROM CENTER TO 1572 01:01:07,909 --> 01:01:10,211 AN INSTITUTE. THERE IS A PROCESS 1573 01:01:10,211 --> 01:01:12,013 WITHIN THE GOVERNMENT WE USE TO 1574 01:01:12,013 --> 01:01:14,048 DO THIS, THE A 19 PROCESS. THAT 1575 01:01:14,048 --> 01:01:16,651 IS SOMETHING WE ARE CONSIDERING 1576 01:01:16,651 --> 01:01:19,587 PURSUING, IT REQUIRES HHS AND 1577 01:01:19,587 --> 01:01:22,557 OMB APPROVAL. FOR A VARY OF 1578 01:01:22,557 --> 01:01:23,958 REASONS THIS IS ON HOLD AT THIS 1579 01:01:23,958 --> 01:01:25,726 TIME BUT I WANT TO LET YOU KNOW 1580 01:01:25,726 --> 01:01:26,961 WE ARE STILL THINKING ABOUT THIS 1581 01:01:26,961 --> 01:01:29,530 PROCESS AND HOPE TO PURSUE IT AT 1582 01:01:29,530 --> 01:01:31,766 SOME STAGE. IN THE MEANTIME ALSO 1583 01:01:31,766 --> 01:01:35,803 GAVE ME AN OPPORTUNITY TO THANK 1584 01:01:35,803 --> 01:01:37,405 PHYSICIANS COMMITTEE FOR THEIR 1585 01:01:37,405 --> 01:01:40,108 RESPONSIBLE MEDICINE AS WELL. 1586 01:01:40,108 --> 01:01:42,610 WITH THAT, I THINK I WANT TO GO 1587 01:01:42,610 --> 01:01:44,112 TO NEXT -- THE LAST SLIDE HERE 1588 01:01:44,112 --> 01:01:47,548 WHICH IS SUMMARY OF THE 1589 01:01:47,548 --> 01:01:49,283 PRESENTATION AND I WON'T GO 1590 01:01:49,283 --> 01:01:50,651 THROUGH IT BUT GIVES ME AN 1591 01:01:50,651 --> 01:01:51,486 OPPORTUNITY TO LEAVE IT ON THE 1592 01:01:51,486 --> 01:01:55,456 SCREEN HERE AN OPEN IT UP FOR 1593 01:01:55,456 --> 01:01:56,390 ANY QUESTIONS. I WILL SAY MAYBE 1594 01:01:56,390 --> 01:01:59,861 WE CAN DO IT IN ORDER. LET'S DO 1595 01:01:59,861 --> 01:02:01,329 TRIENNIAL REPORT, I LOVE YOUR 1596 01:02:01,329 --> 01:02:03,264 COMMENTS ON THAT SO WE CAN MAKE 1597 01:02:03,264 --> 01:02:04,298 SURE WE CERTIFY THAT 1598 01:02:04,298 --> 01:02:05,566 APPROPRIATELY AND WE WILL OPEN 1599 01:02:05,566 --> 01:02:08,269 UP FOR BROADER QUESTIONS 1600 01:02:08,269 --> 01:02:09,971 THEREAFTER. ANY COMMENTS ON THAT 1601 01:02:09,971 --> 01:02:20,515 TRIENNIAL REPORT? IF NONE IS THE 1602 01:02:22,984 --> 01:02:25,153 ANSWER THAT'S FINE TOO. 1603 01:02:25,153 --> 01:02:26,420 HOPEFULLY, PLEASE GO AHEAD 1604 01:02:26,420 --> 01:02:30,691 >> THANK YOU SO MUCH FOR JOINING 1605 01:02:30,691 --> 01:02:36,097 FOR THIS REALLY GOOD OVERVIEW OF 1606 01:02:36,097 --> 01:02:37,732 THE ACTIVITIES I GREATLY 1607 01:02:37,732 --> 01:02:41,102 APPRECIATE IT. IN TERMS OF THE 1608 01:02:41,102 --> 01:02:48,276 TRIENNIAL REPORT ONE HIGHLIGHT 1609 01:02:48,276 --> 01:02:50,745 FOR ME IS WHEN YOU PRESENT IT IN 1610 01:02:50,745 --> 01:02:52,446 TERMS OF TRAINEES CERTAINLY 1611 01:02:52,446 --> 01:02:55,183 LATINOS FROM 2022 TO 2024, THAT 1612 01:02:55,183 --> 01:02:59,320 IS A VERY STRONG EXAMPLE OF WHY 1613 01:02:59,320 --> 01:03:03,324 IT IS CRITICALLY IMPORTANT TO 1614 01:03:03,324 --> 01:03:04,725 CONTINUE TO HAVE A FINGER ON 1615 01:03:04,725 --> 01:03:09,463 THAT PULSE. TO COLLECT DATA 1616 01:03:09,463 --> 01:03:12,133 USING RACE AND ETHNICITY. I WANT 1617 01:03:12,133 --> 01:03:14,001 TO THANK YOU FOR BRINGING THAT 1618 01:03:14,001 --> 01:03:19,774 TO OUR ATTENTION AND ALSO SO 1619 01:03:19,774 --> 01:03:20,141 EMPHASIZE. 1620 01:03:20,141 --> 01:03:22,443 >> THANK YOU SO MUCH. SUPPORT OF 1621 01:03:22,443 --> 01:03:22,643 THAT. 1622 01:03:22,643 --> 01:03:24,178 >> FANTASTIC. THANK Y THANK YOUL 1623 01:03:24,178 --> 01:03:26,180 CONTINUE TO DO THIS, IT IS A 1624 01:03:26,180 --> 01:03:28,616 MANDATED ACTIVITY. I REALLY 1625 01:03:28,616 --> 01:03:32,053 APPRECIATE THAT, IT IS GOOD TO 1626 01:03:32,053 --> 01:03:34,155 SEE WE ARE BRINGING IN A VARIETY 1627 01:03:34,155 --> 01:03:35,823 OF POPULATIONS AND REPRESENTING 1628 01:03:35,823 --> 01:03:38,492 DIFFERENT RACIAL ETHNIC GROUPS 1629 01:03:38,492 --> 01:03:42,463 AND I AGREE IT IS GOOD TO SEE 1630 01:03:42,463 --> 01:03:45,866 THOSE TRENDS. THANK YOU. ANY 1631 01:03:45,866 --> 01:03:46,567 OTHER QUESTIONS OR COMMENTS 1632 01:03:46,567 --> 01:03:51,806 ONNA? PERHAPS HEARING NONE I'M 1633 01:03:51,806 --> 01:03:54,075 HAPPY TO JUST OPEN THIS UP TO 1634 01:03:54,075 --> 01:03:55,443 ANY OTHER QUESTIONS OR COMMENTS 1635 01:03:55,443 --> 01:03:58,312 YOU MIGHT HAVE. 1636 01:03:58,312 --> 01:04:01,015 >> YES. PAUL. 1637 01:04:01,015 --> 01:04:01,949 >> THANK YOU FOR THAT 1638 01:04:01,949 --> 01:04:07,121 PRESENTATION. THINKING ABOUT NC 1639 01:04:07,121 --> 01:04:10,191 3 AND KNOWING (INDISCERNIBLE) 1640 01:04:10,191 --> 01:04:13,427 RETIRED AND NOW SAM AND JOSH 1641 01:04:13,427 --> 01:04:18,499 HAVE LEFT WHO IS LEADING N 3C? 1642 01:04:18,499 --> 01:04:20,067 WHAT SORT OF SUCCESSION PLAN 1643 01:04:20,067 --> 01:04:21,736 THERE LOOK LIKE? 1644 01:04:21,736 --> 01:04:23,904 >> GREAT QUESTION. SO PAUL YOU 1645 01:04:23,904 --> 01:04:25,139 BROKE UP A LITTLE BIT THERE BUT 1646 01:04:25,139 --> 01:04:28,309 I THINK I GOT YOUR QUESTION. 1647 01:04:28,309 --> 01:04:30,811 YES. SO MANY PEOPLE HAVE BEEN 1648 01:04:30,811 --> 01:04:32,380 FOUNDATIONAL TO N 3C AND HAVE 1649 01:04:32,380 --> 01:04:37,551 BEEN REALLY THE FACE OF IT. 1650 01:04:37,551 --> 01:04:41,022 THERE HAS BEEN A SORT OF LIKE AN 1651 01:04:41,022 --> 01:04:41,922 ICEBERG, YOU HAVE SEEN THE 1652 01:04:41,922 --> 01:04:43,791 ICEBERG BUT UNDERNEATH THE WATER 1653 01:04:43,791 --> 01:04:46,694 THERE IS A WHOLE BUNCH OF PEOPLE 1654 01:04:46,694 --> 01:04:48,996 WHO SUPPORT THE WORK THAT GOES 1655 01:04:48,996 --> 01:04:56,537 ON. SO WE HAVE THE LUXURY AND OF 1656 01:04:56,537 --> 01:04:58,539 -- AND REALLY THE TALENT TO 1657 01:04:58,539 --> 01:04:59,674 SUPPORT CONTINUING THOSE 1658 01:04:59,674 --> 01:05:01,342 ACTIVITIES. SO WE ARE ABLE TO BE 1659 01:05:01,342 --> 01:05:04,879 VERY SEAMLESS IN MOVING FORWARD 1660 01:05:04,879 --> 01:05:07,848 WITH THE CHANGES IN THOSE 1661 01:05:07,848 --> 01:05:10,318 LEADERSHIP POSITIONS. WE HAVE 1662 01:05:10,318 --> 01:05:13,354 ACTING CIO WHO HAS BEEN CRITICAL 1663 01:05:13,354 --> 01:05:15,456 WORKING WITH OTHER COLLABORATORS 1664 01:05:15,456 --> 01:05:20,661 AND STAFF WITHIN NCATS, NATHAN 1665 01:05:20,661 --> 01:05:21,696 (INDISCERNIBLE) EXPERT BUILDING 1666 01:05:21,696 --> 01:05:23,564 THE ARCHITECTURE, 1667 01:05:23,564 --> 01:05:27,335 (INDISCERNIBLE) WHO IS REALLY N 1668 01:05:27,335 --> 01:05:31,105 3C, HE IS N 3C, REALLY THE GURU 1669 01:05:31,105 --> 01:05:33,441 BEHIND A LOT OF WORK THAT IS 1670 01:05:33,441 --> 01:05:37,645 THAT MAKES N 3C GO. HE'S 1671 01:05:37,645 --> 01:05:39,313 THINKING THROUGH THE NEW 1672 01:05:39,313 --> 01:05:40,481 DIRECTIONS AND GOVERNANCE 1673 01:05:40,481 --> 01:05:41,482 MODELING AND OPERATIONAL 1674 01:05:41,482 --> 01:05:42,817 APPROACHES AS WELL AS WE MOVE 1675 01:05:42,817 --> 01:05:46,020 INTO THE NEXT PHASE OF MORE 1676 01:05:46,020 --> 01:05:47,455 TENANT ENCLAVE MODEL DEVELOPMENT 1677 01:05:47,455 --> 01:05:49,323 AND HE IS REALLY THOUGHT THROUGH 1678 01:05:49,323 --> 01:05:50,925 THAT. IN TERMS OF HEEDER SHIP WE 1679 01:05:50,925 --> 01:05:54,395 HAVE A VARIETY OF LEADER TOO. WE 1680 01:05:54,395 --> 01:05:58,332 HAVE MIKE CIRILLA, CTSA AND 1681 01:05:58,332 --> 01:06:00,601 DIVISION OF CLINICAL INNOVATIONS 1682 01:06:00,601 --> 01:06:02,236 DIRECTOR. HE OVERSEES A LOT OF 1683 01:06:02,236 --> 01:06:03,804 THESE ACTIVITIES BECAUSE HE IS 1684 01:06:03,804 --> 01:06:05,473 SUPPORTED OUT OF THE CTSA 1685 01:06:05,473 --> 01:06:07,775 PROGRAM LARGELY HE IS CONTINUING 1686 01:06:07,775 --> 01:06:10,544 TO ACHE THAT RESPONSIBILITY AS 1687 01:06:10,544 --> 01:06:14,315 WELL AS OUR FOLKS IN HIS SHOP. 1688 01:06:14,315 --> 01:06:16,250 WE HAVE PERSON REALLY FOCUSED ON 1689 01:06:16,250 --> 01:06:17,618 POLICY DEVELOPMENTS TOO AND 1690 01:06:17,618 --> 01:06:19,820 WORKING ACROSS THE NIH. WE HAVE 1691 01:06:19,820 --> 01:06:22,223 A LEADER IN CHRIS DILLON 1692 01:06:22,223 --> 01:06:23,491 THINKING ABOUT OUR AGREEMENTS 1693 01:06:23,491 --> 01:06:26,026 THAT WE USE WITHIN THESE 1694 01:06:26,026 --> 01:06:28,129 ACTIVITIES. SO THERE IS NOT 1695 01:06:28,129 --> 01:06:29,263 REALLY I WOULD SAY ONE PERSON, 1696 01:06:29,263 --> 01:06:30,631 IT IS REALLY A GROUP OF 1697 01:06:30,631 --> 01:06:33,267 LEADERSHIP THAT COMES TOGETHER 1698 01:06:33,267 --> 01:06:34,802 THAT IS REALLY MANAGING HOW WE 1699 01:06:34,802 --> 01:06:37,338 MOVE FORWARD. AND IT'S AN 1700 01:06:37,338 --> 01:06:39,607 INCREDIBLE GROUP TO BE PART OF. 1701 01:06:39,607 --> 01:06:41,675 >> THANK YOU. 1702 01:06:41,675 --> 01:06:45,513 >> I SHOULD ALSO SAY SAM AND 1703 01:06:45,513 --> 01:06:47,948 JOSH AND KEN, THEY REALLY HAVE 1704 01:06:47,948 --> 01:06:51,519 BEEN THE DREAM TEAM TO GET THAT 1705 01:06:51,519 --> 01:06:53,454 STARTED. NOW WE HAVE DREAM TEAM 1706 01:06:53,454 --> 01:06:55,055 TO TAKE US TO THE NEXT PHASE SO 1707 01:06:55,055 --> 01:06:57,525 THE BEST OF ALL WORLDS THAT HAVE 1708 01:06:57,525 --> 01:06:59,360 HAPPENED AROUND HERE. 1709 01:06:59,360 --> 01:07:01,862 >> THANKS. 1710 01:07:01,862 --> 01:07:06,100 >> JONATHAN? I THINK SERGIO'S 1711 01:07:06,100 --> 01:07:08,736 HAND WAS UP BEFORE. THAT'S 1712 01:07:08,736 --> 01:07:09,136 RIGHT? 1713 01:07:09,136 --> 01:07:13,174 >> NO ACTUALLY IT WAS -- YES. I 1714 01:07:13,174 --> 01:07:14,875 WILL FOLLOW HIM. 1715 01:07:14,875 --> 01:07:18,646 >> JONATHAN. 1716 01:07:18,646 --> 01:07:21,582 >> JONI, THIS IS MY FIRST NCATS 1717 01:07:21,582 --> 01:07:22,616 COUNCIL MEETING, IT IS A 1718 01:07:22,616 --> 01:07:22,883 PLEASURE. 1719 01:07:22,883 --> 01:07:23,918 >> WELCOME. 1720 01:07:23,918 --> 01:07:25,453 >> TO BE ON THE COUNCIL AND IT 1721 01:07:25,453 --> 01:07:28,789 WAS JUST SO REFLESHING HONESTLY 1722 01:07:28,789 --> 01:07:32,660 TO HEAR HOW NIMBLE AND AGILE 1723 01:07:32,660 --> 01:07:35,095 NCATS IS REALLY SUPPORTING 1724 01:07:35,095 --> 01:07:37,431 CUTTING EDGE TECHNOLOGY AND 1725 01:07:37,431 --> 01:07:39,233 ENABLING INNOVATION ACROSS THE 1726 01:07:39,233 --> 01:07:42,436 NIH, IT IS NOT JUST WITHIN NCATS 1727 01:07:42,436 --> 01:07:45,372 BUT SUPPORTING INNOVATION ACROSS 1728 01:07:45,372 --> 01:07:47,975 THE ENTIRE NIH THROUGH THE 1729 01:07:47,975 --> 01:07:49,076 CTSAs BUT THROUGH ALL THE 1730 01:07:49,076 --> 01:07:50,811 OTHER INITIATIVES AS WELL. SO IT 1731 01:07:50,811 --> 01:07:53,314 IS REALLY GREAT TO HEAR. YOUR 1732 01:07:53,314 --> 01:07:55,416 POINT ABOUT THE PHASE 3 TRIALS, 1733 01:07:55,416 --> 01:07:58,085 YOU HAVE THE CTSAs IF EVER 1734 01:07:58,085 --> 01:08:01,455 THERE WAS A GOOD VEHICLE FOR 1735 01:08:01,455 --> 01:08:03,123 SUPPORTING PHASE 3 TRIALS YOU 1736 01:08:03,123 --> 01:08:04,592 WOULD THINK COMBINING THE KINDS 1737 01:08:04,592 --> 01:08:08,162 OF INNOVATION TAKING PLACE 1738 01:08:08,162 --> 01:08:10,698 INSIDE NCATS WITH WHAT THE 1739 01:08:10,698 --> 01:08:13,033 CTSAs COULD DO TO IMPLEMENT 1740 01:08:13,033 --> 01:08:14,535 THOSE TRIALS, I WOULD IT WOULD 1741 01:08:14,535 --> 01:08:17,538 SEEM IF THERE IS A WAY FOR NCATS 1742 01:08:17,538 --> 01:08:21,342 TO BECOME MORE LEADER IN 1743 01:08:21,342 --> 01:08:22,676 IMPLEMENTING PHASE 3 CLINICAL 1744 01:08:22,676 --> 01:08:24,044 TRIALS, THAT THAT WOULD BE 1745 01:08:24,044 --> 01:08:26,947 BENEFICIAL I THINK ACROSS THE 1746 01:08:26,947 --> 01:08:27,515 ENTIRE NIH. 1747 01:08:27,515 --> 01:08:29,416 >> AGREE. THANK YOU FOR THAT 1748 01:08:29,416 --> 01:08:31,652 COMMENT, JONATHAN. WELCOME 1749 01:08:31,652 --> 01:08:37,491 ABOARD. I COULDN'T AGREE MORE. 1750 01:08:37,491 --> 01:08:40,928 IT STRIKES ME GIVEN THE CHANGES 1751 01:08:40,928 --> 01:08:45,232 IN THE MODALITIES THAT ARE BEING 1752 01:08:45,232 --> 01:08:48,335 DEVELOPED NOW, THESE TYPES OF 1753 01:08:48,335 --> 01:08:51,805 GENE EDITING TECHNOLOGIES, GENE 1754 01:08:51,805 --> 01:08:53,607 THERAPY PROTAX ANTIBODY 1755 01:08:53,607 --> 01:08:54,275 DEVELOPMENT, ALL THESE THINGS 1756 01:08:54,275 --> 01:08:56,844 ARE GOING TO REQUIRE KIND OF A 1757 01:08:56,844 --> 01:08:57,645 DIFFERENT WAY OF THINKING ABOUT 1758 01:08:57,645 --> 01:09:02,716 CLINICAL TRIALS TOO. AND IN 1759 01:09:02,716 --> 01:09:03,918 ADDITION THINKING ABOUT THE 1760 01:09:03,918 --> 01:09:08,689 DIFFERENT DISEASES THAT ARE IN 1761 01:09:08,689 --> 01:09:09,590 CHRONIC FORM AFFECTING DIFFERENT 1762 01:09:09,590 --> 01:09:11,392 PEOPLE WHO ALSO HAVE OTHER 1763 01:09:11,392 --> 01:09:13,861 CHRONIC DISEASES THAT ARE IN THE 1764 01:09:13,861 --> 01:09:15,062 BACKGROUND, THOSE CO-MORBID 1765 01:09:15,062 --> 01:09:16,096 CONDITIONS AND HOW WE THINK 1766 01:09:16,096 --> 01:09:17,798 ABOUT THE DESIGN AND 1767 01:09:17,798 --> 01:09:18,832 IMPLEMENTATION OF THOSE PHASE 3 1768 01:09:18,832 --> 01:09:21,569 TRIALS TO UNDERSTAND THE 1769 01:09:21,569 --> 01:09:22,770 IMPORTANCE OF PRODUCTS UNDER 1770 01:09:22,770 --> 01:09:24,772 REVIEW. I THINK THIS IS 1771 01:09:24,772 --> 01:09:30,578 CRITICAL. THEN THE OTHER I THINK 1772 01:09:30,578 --> 01:09:32,046 REAL REAL NEED IS AROUND THE 1773 01:09:32,046 --> 01:09:33,247 RARE DISEASE SPACE BECAUSE WE 1774 01:09:33,247 --> 01:09:34,582 HAVE THIS SPECIAL EXPERTISE IN 1775 01:09:34,582 --> 01:09:36,150 THAT SPACE, I THINK THAT THAT 1776 01:09:36,150 --> 01:09:37,518 WOULD HELP US THINK THROUGH 1777 01:09:37,518 --> 01:09:46,093 THOSE DESIGNS EVEN BETTER 1778 01:09:46,093 --> 01:09:46,994 WITHOUT THAT RESTRICTION. WE 1779 01:09:46,994 --> 01:09:48,796 WOULDN'T HAVE TO STOP MOMENTUM 1780 01:09:48,796 --> 01:09:50,097 OF A PARTICULAR STUDY MOVING 1781 01:09:50,097 --> 01:09:53,300 FROM PERHAPS PHASE 2 TO PHASE 3 1782 01:09:53,300 --> 01:09:55,169 WHILE WE AWAIT APPROVALS FOR 1783 01:09:55,169 --> 01:09:57,204 RARE DISEASES. WE HAVE TO 1784 01:09:57,204 --> 01:09:58,305 USUALLY WAIT FOR COUPLE OF O 1785 01:09:58,305 --> 01:10:00,641 MONTHS IN THE FEDERAL REGISTRAR 1786 01:10:00,641 --> 01:10:02,343 BEFORE WE CAN PROCEEDS WITH 1787 01:10:02,343 --> 01:10:05,212 THESE THREE TRIALS FOR RARE 1788 01:10:05,212 --> 01:10:06,347 DISEASES, FOR OTHERS WE ARE 1789 01:10:06,347 --> 01:10:11,885 STILL PROHIBITED. AND THAT 1790 01:10:11,885 --> 01:10:15,823 PARTICULAR TIME REQUIREMENT WE 1791 01:10:15,823 --> 01:10:16,890 LOSE GROUNDS IF WE HAVE TO STOP 1792 01:10:16,890 --> 01:10:17,891 THOSE SO FOR A VARIETY OF 1793 01:10:17,891 --> 01:10:19,159 REASONS YOU ARE DEFINITELY ON 1794 01:10:19,159 --> 01:10:25,566 POINT. AND I I HOPE WE CAN 1795 01:10:25,566 --> 01:10:28,335 FIGURE WAYS TO NAVIGATE THIS. WE 1796 01:10:28,335 --> 01:10:30,270 HAVE TO AT A TIME DONE A REALLY 1797 01:10:30,270 --> 01:10:31,472 GOOD JOB BUT TIME TO THINK HOW 1798 01:10:31,472 --> 01:10:33,240 TO DO A LITTLE MORE. THANK YOU. 1799 01:10:33,240 --> 01:10:34,742 SERGIO, YES, PLEAS PLEASE. 1800 01:10:34,742 --> 01:10:40,447 >> JUST TWO MORE COMMENTS, JONI. 1801 01:10:40,447 --> 01:10:42,883 ONE IS THANK YOU FOR PRESENTING 1802 01:10:42,883 --> 01:10:44,151 THE THIRD EDITION OF THE 1803 01:10:44,151 --> 01:10:48,122 PRINCIPLES OF COMMUNITY 1804 01:10:48,122 --> 01:10:49,890 ENGAGEMENT AND -- WE GREATLY 1805 01:10:49,890 --> 01:10:50,257 APPRECIATE THAT. 1806 01:10:50,257 --> 01:10:51,525 >> CONGRATULATIONS TO YOU. 1807 01:10:51,525 --> 01:10:54,128 >> AND TO MANY, MANY OTHER 1808 01:10:54,128 --> 01:10:57,898 PEOPLE. THESE ONES ARE COLLECTED 1809 01:10:57,898 --> 01:11:00,668 EFFORTS WITH MANY, MANY 1810 01:11:00,668 --> 01:11:03,337 COMMUNITY MEMBERS. SO IT IS 1811 01:11:03,337 --> 01:11:05,072 ABSOLUTELY WORTH CHECKING THAT 1812 01:11:05,072 --> 01:11:07,775 OUT. THANK YOU FOR THE LINK 1813 01:11:07,775 --> 01:11:10,944 THAT YOU INCLUDED AS WELL. JUST 1814 01:11:10,944 --> 01:11:14,048 A COUPLE OF HIGHLIGHTS THAT I 1815 01:11:14,048 --> 01:11:15,582 WANT TO COMPLIMENT WHAT YOU 1816 01:11:15,582 --> 01:11:19,586 SAID. ONE IS THAT THERE IS A 1817 01:11:19,586 --> 01:11:24,024 NEW PRINCIPLE FIRST EDITION AND 1818 01:11:24,024 --> 01:11:25,392 SECOND HAD ONLY NINE PRINCIPLES 1819 01:11:25,392 --> 01:11:26,927 BUT THIRD EDITION HAS A 1820 01:11:26,927 --> 01:11:29,196 PRINCIPLE ON TRUSTWORTHINESS AS 1821 01:11:29,196 --> 01:11:33,634 A FOUNDATIONAL ELEMENT FOR 1822 01:11:33,634 --> 01:11:34,735 ADVANCING HEALTH AND HEALTH 1823 01:11:34,735 --> 01:11:38,639 EQUITY. I WOULD ENCOURAGE THOSE 1824 01:11:38,639 --> 01:11:43,811 IN ATTENDANCE TO CHECK IT OUT. 1825 01:11:43,811 --> 01:11:46,814 ALSO THERE ARE 14 EXEMPLARS OR 1826 01:11:46,814 --> 01:11:48,182 CASE STUDIES THAT ILLUSTRATE THE 1827 01:11:48,182 --> 01:11:53,587 USE OF THE PRINCIPLES AS WELL. 1828 01:11:53,587 --> 01:11:55,122 THERE IS A NEW DEFINITION OF 1829 01:11:55,122 --> 01:11:56,790 COMMUNITY ENGAGEMENT THAT I 1830 01:11:56,790 --> 01:11:58,459 REALLY LIKE. CHECK IT OUT, I 1831 01:11:58,459 --> 01:12:06,734 THINK THAT IS A LOT OF POP WAS 1832 01:12:06,734 --> 01:12:09,770 PUT TOGETHER TO REALLY IMPROVE 1833 01:12:09,770 --> 01:12:13,006 PREVIOUS DEFINITIONS. ONE LAST 1834 01:12:13,006 --> 01:12:16,243 THING TO MENTION IS TO MAKE A 1835 01:12:16,243 --> 01:12:20,247 PLUG BECAUSE CHAPTER 1 THAT 1836 01:12:20,247 --> 01:12:21,849 INCLUDES SOME CONCEPTION MODELS 1837 01:12:21,849 --> 01:12:23,650 OF COMMUNITY ENGAGEMENT INCLUDES 1838 01:12:23,650 --> 01:12:27,821 THE NATIONAL ACADEMY OF MEDICINE 1839 01:12:27,821 --> 01:12:29,723 ASSESSING MEANINGFUL COMMUNITY 1840 01:12:29,723 --> 01:12:33,594 ENGAGEMENT CONCEPTUAL MODEL. I 1841 01:12:33,594 --> 01:12:37,598 THINK THOSE FROM MY PERSPECTIVE 1842 01:12:37,598 --> 01:12:40,234 TO LAND MARK CIBCS THIS YEAR FOR 1843 01:12:40,234 --> 01:12:45,639 CONTRIBUTIONS FORBRINGING IN COT 1844 01:12:45,639 --> 01:12:47,074 SO THANK YOU FOR BRINGING THAT 1845 01:12:47,074 --> 01:12:47,341 ATTENTION. 1846 01:12:47,341 --> 01:12:48,842 >> THANK YOU, I'M SO GLAD YOU 1847 01:12:48,842 --> 01:12:50,744 ADDED THAT POINT, ALL OF THOSE 1848 01:12:50,744 --> 01:12:52,079 POINTS BUT THAT -- TALKING ABOUT 1849 01:12:52,079 --> 01:12:55,282 THE NATIONAL ACADEMIES 1850 01:12:55,282 --> 01:12:56,650 INVOLVEMENT FOR THAT PARTICULAR 1851 01:12:56,650 --> 01:12:58,185 ASPECT. ONE OF THOSE THINGS THAT 1852 01:12:58,185 --> 01:13:02,589 INSPIRED ME TOO, BECAUSE OF THE 1853 01:13:02,589 --> 01:13:05,793 WORK THEY HAVE DONE. WHEN I 1854 01:13:05,793 --> 01:13:06,460 THOUGHT ABOUT THAT PARTICULAR 1855 01:13:06,460 --> 01:13:08,362 SECTION AND WHAT NATIONAL 1856 01:13:08,362 --> 01:13:11,331 ACADEMIES REPORT DID WAS IT MADE 1857 01:13:11,331 --> 01:13:13,100 YOU THINK YOUR ASSUMPTIONS THAT 1858 01:13:13,100 --> 01:13:15,669 YOU MAKE WHEN COW DO COMMUNITY 1859 01:13:15,669 --> 01:13:17,871 ENGAGEMENT. IT REALLY CHALLENGES 1860 01:13:17,871 --> 01:13:19,873 THOSE ASSUMPTIONS. SO TAKING 1861 01:13:19,873 --> 01:13:23,977 NOTE OF THAT I THINK IS I THINK 1862 01:13:23,977 --> 01:13:25,779 THE PRINCIPLES THE THIRD EDITION 1863 01:13:25,779 --> 01:13:28,215 DOES A NICE JOB OF TALKING ABOUT 1864 01:13:28,215 --> 01:13:30,884 THAT. THANK YOU SO MUCH, SERGIO, 1865 01:13:30,884 --> 01:13:32,352 FOR YOUR LEADERSHIP AND THE 1866 01:13:32,352 --> 01:13:34,488 WHOLE COMMUNITY FOR THEIR 1867 01:13:34,488 --> 01:13:36,089 INVOLVEMENT IN THIS BODY OF 1868 01:13:36,089 --> 01:13:38,926 WORK. IT IS FANTASTIC. 1869 01:13:38,926 --> 01:13:42,729 >> MY PLEASURE. ONE LAST COMMENT 1870 01:13:42,729 --> 01:13:44,565 JONI, I'M SORRY I'M SPEAKING TOO 1871 01:13:44,565 --> 01:13:46,733 MUCH PERHAPS. I'M DELIGHTED 1872 01:13:46,733 --> 01:13:53,106 THAT TO SEE IN THE WEBSITE THAT 1873 01:13:53,106 --> 01:13:56,210 2025, 2030 STRATEGIC PLAN IS 1874 01:13:56,210 --> 01:13:59,847 AVAILABLE. BECAUSE THAT IS SUCH 1875 01:13:59,847 --> 01:14:02,482 A REMARKABLE CONTRIBUTION THAT 1876 01:14:02,482 --> 01:14:07,688 NCATS NEED WITH THIS INCREDIBLE 1877 01:14:07,688 --> 01:14:10,824 ELABORATE APPROACHES. LISTENING, 1878 01:14:10,824 --> 01:14:12,593 LISTENING TO COMMUNITIES, 1879 01:14:12,593 --> 01:14:15,162 LISTENING SESSIONS THAT YOU LED 1880 01:14:15,162 --> 01:14:21,368 THAT ARE INFORMED BY VARIOUS 1881 01:14:21,368 --> 01:14:24,037 GROUPS OF INTEREST INCLUDING 1882 01:14:24,037 --> 01:14:27,507 COMMUNITIES. SO I'M DELIGHTED 1883 01:14:27,507 --> 01:14:30,978 THAT YOU TOUCH BASE IN TERMS OF 1884 01:14:30,978 --> 01:14:31,979 IMPLEMENTATION PLAN NOW AND 1885 01:14:31,979 --> 01:14:33,547 UPDATES YOU MENTIONED. THANK YOU 1886 01:14:33,547 --> 01:14:34,147 O FOR DOING THAT. 1887 01:14:34,147 --> 01:14:40,621 >> THANK YOU VERY MUCH. IT WAS A 1888 01:14:40,621 --> 01:14:42,623 LONG PROCESS TO GO THROUGH IN 1889 01:14:42,623 --> 01:14:44,191 TERMS OVERRAN TABLE DISCUSSIONS 1890 01:14:44,191 --> 01:14:45,859 BUT BOY WERE THEY VALUABLE. WE 1891 01:14:45,859 --> 01:14:47,728 COULDN'T DO IT WITHOUT THE 1892 01:14:47,728 --> 01:14:50,831 COMMUNITY, WE HAVE TO BE REALLY 1893 01:14:50,831 --> 01:14:51,732 THINKING ABOUT HOW WE RECOLLECT 1894 01:14:51,732 --> 01:14:52,699 WORK TOGETHER TO MAKE ADVANCES 1895 01:14:52,699 --> 01:14:55,669 HAPPEN. I COULDN'T THINK OF A 1896 01:14:55,669 --> 01:14:56,803 BETTER WAY SO I APPRECIATE YOU 1897 01:14:56,803 --> 01:14:58,872 RECOGNIZING THAT CONTRIBUTION. 1898 01:14:58,872 --> 01:15:01,909 THANK YOU. PAUL. 1899 01:15:01,909 --> 01:15:06,980 >> THANK YOU FOR ADDRESSING THE 1900 01:15:06,980 --> 01:15:08,582 LETTER THAT WE WROTE LAST TIME 1901 01:15:08,582 --> 01:15:10,350 ASKING FOR CONSIDERATION OF 1902 01:15:10,350 --> 01:15:13,020 ELEVATION TO AN INSTITUTE. I 1903 01:15:13,020 --> 01:15:14,888 THINK WE ARE ALL SUPPORTIVE OF 1904 01:15:14,888 --> 01:15:16,490 THAT. IN THE NEWS CYCLE HOWEVER, 1905 01:15:16,490 --> 01:15:19,593 THERE IS A LOT OF INFORMATION 1906 01:15:19,593 --> 01:15:21,528 OUT THERE ABOUT RESTRUCTURING 1907 01:15:21,528 --> 01:15:23,196 NIH. AND POTENTIAL WAYS TO DO 1908 01:15:23,196 --> 01:15:24,564 THAT. CAN YOU SPEAK TO THAT A 1909 01:15:24,564 --> 01:15:28,435 LITTLE BIT AS MUCH AS YOU CAN? 1910 01:15:28,435 --> 01:15:29,903 >> YES, THANKS FOR THAT 1911 01:15:29,903 --> 01:15:37,177 QUESTION, PAUL. I CAN BE 1912 01:15:37,177 --> 01:15:38,879 WATCHING THE NEWS CYCLES AS MUCH 1913 01:15:38,879 --> 01:15:40,414 AS YOU PROBABLY HAVE THE PAST 1914 01:15:40,414 --> 01:15:46,486 FEW DAYS OR LAST 24 HOURS. TO BE 1915 01:15:46,486 --> 01:15:47,621 CLEAR, I DON'T KNOW MORE THAN 1916 01:15:47,621 --> 01:15:48,622 WHAT HAS BEEN REPORTED IN THE 1917 01:15:48,622 --> 01:15:54,161 MEDIA FROM LAST NIGHT. HERE IS 1918 01:15:54,161 --> 01:15:58,265 WHAT I WOULD SAY TO THAT. WHAT 1919 01:15:58,265 --> 01:16:00,133 WAS REPORTING IN MEDIA IS 1920 01:16:00,133 --> 01:16:02,035 ESSENTIALLY THE OFFICE OF THE 1921 01:16:02,035 --> 01:16:03,603 MANAGEMENT AND BUDGET OMB 1922 01:16:03,603 --> 01:16:05,839 PROPOSED DRAFT. WHICH IS PART OF 1923 01:16:05,839 --> 01:16:08,275 THE INTERNAL DELIBERATIONS FOR 1924 01:16:08,275 --> 01:16:13,013 THE FY 26 PRESIDENT'S BUDGET. 1925 01:16:13,013 --> 01:16:15,582 THIS INTERNAL PROCESS ULTIMATELY 1926 01:16:15,582 --> 01:16:17,150 HELPS SHAPE THE PRESIDENT'S 1927 01:16:17,150 --> 01:16:18,652 BUDGET AND BUT THAT HASN'T COME 1928 01:16:18,652 --> 01:16:20,687 OUT YET, IT IS EXPECTED 1929 01:16:20,687 --> 01:16:21,588 RELATIVELY SOON IN THE NEAR 1930 01:16:21,588 --> 01:16:26,793 FUTURE. SO THE ORGANIZATION AND 1931 01:16:26,793 --> 01:16:29,696 THE PROGRAMMATIC CHANGES THESE 1932 01:16:29,696 --> 01:16:30,764 TYPES OF THINGS AREN'T 1933 01:16:30,764 --> 01:16:34,935 NECESSARILY NEW. AND ARE ALSO 1934 01:16:34,935 --> 01:16:36,069 VERY COMMON WITH EVERY NEW 1935 01:16:36,069 --> 01:16:40,674 ADMINISTRATION. NOW WHAT YOU 1936 01:16:40,674 --> 01:16:43,143 MAY HAVE READ LOOKS PROBABLY 1937 01:16:43,143 --> 01:16:46,613 MORE THAN OTHER TIMES WE HAVE 1938 01:16:46,613 --> 01:16:51,485 SEEN. TOO EARLY TO UNDERSTAND 1939 01:16:51,485 --> 01:16:53,286 THAT AND SINCE IT IS THE OMB 1940 01:16:53,286 --> 01:16:54,187 PROPOSED DRAFT IT IS 1941 01:16:54,187 --> 01:16:54,855 INAPPROPRIATE FOR ME TO COMMENT 1942 01:16:54,855 --> 01:16:57,491 TOO MUCH ON THAT. I CAN PROVIDE 1943 01:16:57,491 --> 01:16:58,592 A LITTLE BACKGROUND ON THE 1944 01:16:58,592 --> 01:17:01,328 PROCESS. THE PRESIDENT'S BUDGET 1945 01:17:01,328 --> 01:17:03,997 IS THING THAT KICKS OFF THE FY 1946 01:17:03,997 --> 01:17:07,634 26 APPROPRIATIONS PROCESS IN 1947 01:17:07,634 --> 01:17:09,903 CONGRESS. PRESIDENT'S BOUGHT IS 1948 01:17:09,903 --> 01:17:12,039 EXPECTED IN THE NEAR FUTURE. 1949 01:17:12,039 --> 01:17:14,241 THAT BUDGE PROCESS ONCE THAT IS 1950 01:17:14,241 --> 01:17:15,842 OUT IT LASTS SEVERAL MONTHS WITH 1951 01:17:15,842 --> 01:17:17,811 THE GOAL OF LANDING ON A FINAL 1952 01:17:17,811 --> 01:17:20,113 BUDGET BY THE BEGINNING OF THE 1953 01:17:20,113 --> 01:17:23,750 NEW FISCAL YEAR IN FY 26 WHICH 1954 01:17:23,750 --> 01:17:25,419 STARTS OCTOBER 21. SO THERE IS A 1955 01:17:25,419 --> 01:17:26,686 COUPLE OF MONTHS TO GO STILL AND 1956 01:17:26,686 --> 01:17:27,587 UNDERSTANDING HOW THIS IS IS 1957 01:17:27,587 --> 01:17:29,923 GOING TO PLAY OUT. THE PROCESS 1958 01:17:29,923 --> 01:17:31,491 INCLUDES MANY HEARINGS WITH 1959 01:17:31,491 --> 01:17:33,660 VARIOUS DEPARTMENTS AND AGENCY 1960 01:17:33,660 --> 01:17:35,228 LEADERS. AS WELL AS THE HOUSE 1961 01:17:35,228 --> 01:17:37,898 AND THE SENATE APPROPRIATIONS 1962 01:17:37,898 --> 01:17:39,766 COMMITTEES. THE HOUSE AND SENATE 1963 01:17:39,766 --> 01:17:40,767 APPROPRIATION COMMITTEES WILL 1964 01:17:40,767 --> 01:17:44,171 GET INPUT FROM ADMINISTRATION, 1965 01:17:44,171 --> 01:17:45,639 THEY WILL BUILT DRAFTS AND BILLS 1966 01:17:45,639 --> 01:17:47,407 AND THEN THE REPORT LANGUAGE 1967 01:17:47,407 --> 01:17:49,843 THAT CONGRESS ULTIMATELY VOTES 1968 01:17:49,843 --> 01:17:51,645 ON RELATED TO THIS. THAT IS 1969 01:17:51,645 --> 01:17:56,416 ESSENTIALLY THE PROCESS. THIS IS 1970 01:17:56,416 --> 01:17:57,651 SIGNIFYING THAT PROCESS IS ABOUT 1971 01:17:57,651 --> 01:18:00,087 THE START BUT THIS IS REALLY 1972 01:18:00,087 --> 01:18:04,124 PROPOSED DRAFT WE HAVE SEEN. I 1973 01:18:04,124 --> 01:18:06,126 JUST HAVEN'T -- I DON'T KNOW 1974 01:18:06,126 --> 01:18:06,927 MUCH MORE HABIT THAT AT THIS 1975 01:18:06,927 --> 01:18:12,732 TIME. THIS TIME OF COURSE NCATS 1976 01:18:12,732 --> 01:18:13,867 WILL CONTINUE TO BE GROUNDED IN 1977 01:18:13,867 --> 01:18:15,769 OUR MISSION OF BRINGING MORE 1978 01:18:15,769 --> 01:18:18,305 TREATMENTS TO ALL PEOPLE MORE 1979 01:18:18,305 --> 01:18:21,608 QUICKLY. AS I SHOWED TODAY, I 1980 01:18:21,608 --> 01:18:23,710 THINK WE DO A PRETTY GOOD JOB OF 1981 01:18:23,710 --> 01:18:25,245 THAT BECAUSE OUR TEAM SCIENCE 1982 01:18:25,245 --> 01:18:28,148 APPROACH AND WORKING ACROSS THE 1983 01:18:28,148 --> 01:18:29,783 NIH AND WORKING ACROSS THE 1984 01:18:29,783 --> 01:18:32,652 ENTIRE BIOMEDICAL ECOSYSTEM IS 1985 01:18:32,652 --> 01:18:33,420 HOW WE HAVE BEEN ABLE TO BE 1986 01:18:33,420 --> 01:18:38,091 SUCCESSFUL IN THAT RASH. SO 1987 01:18:38,091 --> 01:18:38,792 PROBABLY DIDN'T ANSWER YOUR 1988 01:18:38,792 --> 01:18:40,393 QUESTION VERY WELL BUT HOPE THAT 1989 01:18:40,393 --> 01:18:42,963 GAVE YOU A LITTLE INSIGHT INTO 1990 01:18:42,963 --> 01:18:46,133 WHAT HAPPENS NEXT. 1991 01:18:46,133 --> 01:18:47,934 >> THANK YOU. I ASKED AS MUCH AS 1992 01:18:47,934 --> 01:18:49,402 YOU COULD AND YOUOVER DELIVERED 1993 01:18:49,402 --> 01:18:53,707 SO THANK YOU. 1994 01:18:53,707 --> 01:18:57,277 >> THANK YOU. ARE THERE ANY 1995 01:18:57,277 --> 01:19:01,281 OTHER QUESTIONS? I DON'T SEE ANY 1996 01:19:01,281 --> 01:19:10,657 HANDS. OKAY. IN THAT CASE, 1997 01:19:10,657 --> 01:19:13,994 ANNA, I THINK I MIGHT WANT TO 1998 01:19:13,994 --> 01:19:19,199 TURN IT OVER TO YOU. SINCE OUR 1999 01:19:19,199 --> 01:19:20,667 OPENING DIRECTOR'S REPORT IS NOW 2000 01:19:20,667 --> 01:19:24,037 CONCLUDED. SHALL I TURN IT OVER 2001 01:19:24,037 --> 01:19:32,779 TO YOU? ANNA, ARE YOU THERE? WE 2002 01:19:32,779 --> 01:19:34,614 MAY HAVE LOST ANNA. I HOPE WE 2003 01:19:34,614 --> 01:19:39,319 DIDN'T LOSE THE ROOM. 2004 01:19:39,319 --> 01:19:47,360 >> THE AUDIO COMING THROUGH. 2005 01:19:47,360 --> 01:19:49,329 SPEAKER5: ANNA IS -- OKAY. ANNA 2006 01:19:49,329 --> 01:19:56,002 IS HERE. SHE MOVED. I BELIEVE WE 2007 01:19:56,002 --> 01:19:58,805 ARE ON ANY PUBLIC COMMENTS. 2008 01:19:58,805 --> 01:19:59,773 >> YES. 2009 01:19:59,773 --> 01:20:07,514 >> OKAY. SHALL I PUT THE VIDEO? 2010 01:20:07,514 --> 01:20:10,517 >> WE DO HAVE A COUPLE OF PUBLIC 2011 01:20:10,517 --> 01:20:12,285 COMMENTS RECEIVED IN THE INPUT 2012 01:20:12,285 --> 01:20:15,055 BOX. WE USUALLY DO NOT ANSWER 2013 01:20:15,055 --> 01:20:17,724 THOSE OR RESPOND TO THOSE LIVE 2014 01:20:17,724 --> 01:20:20,193 BUT TODAY I BELIEVE WE CAN GO 2015 01:20:20,193 --> 01:20:22,729 AHEAD AND PROVIDE RESPONSE TO 2016 01:20:22,729 --> 01:20:24,531 FOLKS WHO BOTHER TO SUBMIT THEM 2017 01:20:24,531 --> 01:20:26,099 TODAY AND REMIND EVERYONE THAT 2018 01:20:26,099 --> 01:20:27,767 COMMENTS CAN BE SUBMITTED UNTIL 2019 01:20:27,767 --> 01:20:29,302 MAY 1 AND THEY CAN BE MADE 2020 01:20:29,302 --> 01:20:33,506 AVAILABLE UPON REQUEST. SO THE 2021 01:20:33,506 --> 01:20:35,842 FIRST QUESTION, I WILL READ IT. 2022 01:20:35,842 --> 01:20:37,410 IS AFTER THE NEW ADMINISTRATION 2023 01:20:37,410 --> 01:20:39,379 AND NIH LEADERSHIP HAS COME 2024 01:20:39,379 --> 01:20:42,182 INTHE PLACE, GRANTS PROPOSED AND 2025 01:20:42,182 --> 01:20:43,516 DELAYED, DESCRIBE TIMING TO 2026 01:20:43,516 --> 01:20:44,851 RESUME AID WARDING OF THE 2027 01:20:44,851 --> 01:20:48,321 BACKLOG OF SBIR STTR GRANTS, 2028 01:20:48,321 --> 01:20:50,357 WHAT IS PLAN REVIEWING AWARDING 2029 01:20:50,357 --> 01:20:53,026 SBIR STTR GRANTS PHYSICAL YEAR. 2030 01:20:53,026 --> 01:20:56,363 HAPPY T TO A-- FISCAL YEAR. THOE 2031 01:20:56,363 --> 01:20:57,931 REVIEWS HAVE RESUMED AND WE 2032 01:20:57,931 --> 01:21:00,367 ANTICIPATE AWARDS WILL BE MADE 2033 01:21:00,367 --> 01:21:02,235 THOUGH MAYBE SOMEWHAT DELAYED. 2034 01:21:02,235 --> 01:21:06,506 THE OTHER QUESTION WE RECEIVED 2035 01:21:06,506 --> 01:21:08,441 WAS WHICH OF THE SEVEN COUNTRIES 2036 01:21:08,441 --> 01:21:11,211 IN TRANSLATIONAL -- TRANSLATION 2037 01:21:11,211 --> 01:21:12,679 TOGETHER PROGRAM AND THE LIST 2038 01:21:12,679 --> 01:21:15,115 THAT WE HAVE AVAILABLE IS 2039 01:21:15,115 --> 01:21:20,086 CANADA, JAPAN, BRAZIL, UK, 2040 01:21:20,086 --> 01:21:21,321 AUSTRALIA, WE ARE ONE OF THE 2041 01:21:21,321 --> 01:21:24,057 SEVEN, AND THE EU BEING HANDLED 2042 01:21:24,057 --> 01:21:28,295 AS A COUNTRY IN THIS CONTEXT. 2043 01:21:28,295 --> 01:21:29,496 THUS FAR WE HAVE NOT RECEIVED 2044 01:21:29,496 --> 01:21:32,766 ADDITIONAL COMMENTS. AGAIN, 2045 01:21:32,766 --> 01:21:34,134 COMMENTS ARE ACCEPTABLE UNTIL 2046 01:21:34,134 --> 01:21:36,236 MAY 1, THEY WILL BE MADE PUBLIC 2047 01:21:36,236 --> 01:21:40,340 IF REQUESTED. THANK YOU. 2048 01:21:40,340 --> 01:21:43,576 >> ALL RIGHT. THANK YOU, ANNA. 2049 01:21:43,576 --> 01:21:46,413 FOR DOING THE ROTATION OF THE 2050 01:21:46,413 --> 01:21:51,251 CAMERA. IN THAT CASE, I BELIEVE 2051 01:21:51,251 --> 01:21:52,919 THAT ANY OTHER QUESTIONS OR 2052 01:21:52,919 --> 01:21:55,455 COMMENTS, THEN WE CAN CONCLUDES 2053 01:21:55,455 --> 01:21:58,224 THE -- CONCLUDE THE OPEN COUNCIL 2054 01:21:58,224 --> 01:22:00,160 TODAY. ONE MORE MINUTE IN CASE 2055 01:22:00,160 --> 01:22:06,633 THERE ARE. I WANT TO SAY THANK 2056 01:22:06,633 --> 01:22:09,636 YOU --. YES. GO AHEAD. 2057 01:22:09,636 --> 01:22:12,372 >> I WANT TO SAY THANK YOU, WE 2058 01:22:12,372 --> 01:22:13,840 APPRECIATE YOUR LEADERSHIP AND 2059 01:22:13,840 --> 01:22:16,309 APPRECIATE YOU IN THE STAFF FOR 2060 01:22:16,309 --> 01:22:19,446 ACCOMMODATING THIS MEETING AND 2061 01:22:19,446 --> 01:22:21,548 INFORMATIVE NATURE OF IT. 2062 01:22:21,548 --> 01:22:24,017 >> THANK YOU VERY MUCH, PAUL. 2063 01:22:24,017 --> 01:22:25,885 THAT MEANS A LOT TO ME, MEANS A 2064 01:22:25,885 --> 01:22:29,122 LOT TO OUR STAFF. I APPRECIATE 2065 01:22:29,122 --> 01:22:30,090 HEARING THAT FROM OUR COUNCIL SO 2066 01:22:30,090 --> 01:22:32,659 THANK YOU. 2067 01:22:32,659 --> 01:22:37,630 >> I STRONGLY ECHO THAT. 2068 01:22:37,630 --> 01:22:41,101 >> IT'S UNANIMOUS. 2069 01:22:41,101 --> 01:22:44,270 >> THANK YOU ALL. JONATHAN, DID 2070 01:22:44,270 --> 01:22:44,971 YOU HAVE ANOTHER COMMENT? 2071 01:22:44,971 --> 01:22:47,340 >> NO, IT WAS TO SAY THANK YOU 2072 01:22:47,340 --> 01:22:49,743 SO MUCH FOR YOUR LEADERSHIP. AND 2073 01:22:49,743 --> 01:22:51,778 FOR YOUR GREAT STAFF IN ALL THAT 2074 01:22:51,778 --> 01:22:54,147 THEY DO. 2075 01:22:54,147 --> 01:22:55,515 >> FANTASTIC. THANK YOU SO MUCH. 2076 01:22:55,515 --> 01:22:57,751 WITH THAT, WE WILL CONCLUDE THE 2077 01:22:57,751 --> 01:23:01,554 OPEN SESSION SO I WILL GAVEL US 2078 01:23:01,554 --> 01:23:03,523 OUT. THANK YOU, EVERYONE. 2079 01:23:03,523 --> 01:23:13,767 >> BYE-BYE.