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WELCOME TO THE 29TH MEETING OF

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THE NCATS ADVISORY COUNCIL AND I

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AM GOING TO SWITCH MY WEB CAM

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FROM THE GAVEL TO ME SO

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HOPEFULLY YOU CAN SEE ME NOW.

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EARLIER THIS MORNING WE WERE

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HAVING POSSIBILITIES OF SNOW

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ICE, THAT SEEMS TO HAVE GONE

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AWAY SO I THINK WE WILL BE IN

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GOOD SHAPE GOING FORWARD.

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THE MEETING TO SPAN A COUPLE OF

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DAYS TODAY AND TOMORROW AND WE

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HAVE A PACKED AGENDA, HOPE YOU

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WILL FIND IT INTERESTING.

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BEFORE WE START, ANNA I WILL

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TURN IT TO YOU FOR THE OFFICIAL

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ROLL CALL.

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>> NEXT SLIDE PLEASE.

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PAUL HARRIS.

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>> HERE.

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>> KRISTINA HARTMAN.

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KRISTINA, ARE YOU THERE?

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TED HOLEMAN.

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>> GOOD MORNING.

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REBECCA JACKSON.

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>> HERE

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>> ANNIE KENNEDY.

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>> HERE.

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>> MATTHIAS KRRETZLER.

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>>ER HUE.

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>> KELLY MCVEARRY.

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>>ER HUE.

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>> KEITH MUELLER

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>> HERE.

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>> RAJESH RANGANATHAN

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>> HERE.

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PAULA SHIREMAN.

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>> HERE.

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>> AND MARSHALL SUMMAR.

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THOSE ARE OUR COUNCIL MEMBERS.

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JONI, BACK TO YOU.

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>> THANK YOU SO MUCH.

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THIS IS THE AGENDA FOR TODAY'S

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PORTION OF THE NCATS COUNCIL AND

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WE HAVE A VARIETY AND

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PROGRAMMATIC UPDATES AND CONCEPT

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CLEARANCES TO I LOOK FORWARD TO

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GOING THROUGH THOSE EVENTS WITH

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YOU.

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I THINK THEN WE'LL ADJOURN FOR

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DAY ONE AND COME BACK TOMORROW

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AT 1 P.M. EASTERN TIME AGAIN.

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AND WE'LL HAVE A VARIETY OF

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PRESENTATIONS FOR TOMORROW AS

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WELL.

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BEFORE WE START WITH DIRECTOR'S

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REPORT I'LL TURN IT TO ANNA FOR

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ANNOUNCEMENTS TO MAKE SURE WE

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ARE ON THE SAME PAGE FOR VARIETY

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OF KEY THINGS YOU NEED TO KNOW

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ABOUT BEFORE WE START THE DAY.

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ANNA BACK TO YOU.

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>> THANK YOU, JONI.

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EVERYONE IN ZOOM MEETING IS A

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PANELIST TODAY SO YOU ARE FREE

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TO SPEAK.

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HOWEVER IN ORDER TO MAINTAIN A

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SMOOTH FLOW WE REQUEST YOU USE

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THE RAISED HAND FEATURE AND WAIT

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UNTIL CALLED UPON TO PROVIDE

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INPUT.

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WE ASK YOU RESERVE USE OF THE

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CHAT FOR ACTIVITIES SUCH AS

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POSTING LINKS PERHAPS,

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INFORMATION, BUT PLEASE USE THE

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CHAT TO A MINIMUM.

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PLEASE ALLOW SPEAKERS TO MOVE

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THROUGH THEIR PRESENTATIONS,

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NOTING YOUR COMMENTS AND THEN

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PRESENTING THEM WHEN CALLED

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UPON.

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WE ARE USING THE VIDEOCAST

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FEATURE TODAY, SO FOR THOSE OF

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YOU WHO ARE NOT IN THE ZOOM

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MEETING, YOU MAY SUBMIT COMMENTS

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BY USING THE EMAIL FUNCTION

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AVAILABLE ON THE NIH VIDEOCAST

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SITE.

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THERE IS A BUTTON THERE AND OR

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YOU CAN SEND EMAIL DIRECTLY TO

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THE ADDRESS LISTED IN THE SLIDE

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NCATS COUNCILINPUT@MAIL.NIH.GOV.

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SO THE FIRST THING I WOULD LIKE

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TO DO IS CONSIDERATION OF OUR

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MINUTES AND OUR NCATS GENERAL

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COUNCIL OPERATING PROCEDURES.

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WE ARE SEEKING APPROVAL OF THE

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MINUTES FOR THE SEPTEMBER 21ST

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MEETING, THEY ARE AVAILABLE IN

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THE ELECTRONIC COUNCIL BOOK.

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COULD WE HAVE A MOTION TO

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APPROVE THE MINUTES FOR THE

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SEPTEMBER 21ST MEETING?

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>> SO MOVE.

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>> THANK YOU.

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SECOND?

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>> SECOND.

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>> ALL IN FAVOR?

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>> A.

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AYE.

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AYE.

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>> ANY OPPOSED?

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ANY ABSTENTIONS?

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THE MINUTES ARE APPROVED.

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I WOULD ALSO NOW LIKE TO MOVE TO

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SEEKING YOUR APPROVAL FOR

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COUNCIL OPERATING PROCEDURES FOR

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2022.

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THESE ARE ALSO AVAILABLE IN YOUR

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ELECTRONIC COUNCIL BOOK.

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COULD WE HAVE A MOTION TO

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APPROVE THE 2022 COUNCIL

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OPERATING PROCEDURES?

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>> SO MOVED.

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>> HE COULD IS.

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>>> SECOND.

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>> ALL IN FAVOR.

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>> A.

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>> ANY OPPOSED?

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ANY ABSTENTION?

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WITH THAT OUR OPERATING

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PROCEDURES FOR 2022 ARE APPROVED

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APPROVED.

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NEXT SLIDE PLEASE.

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FUTURE DATES FOR OUR ADVISORY

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COUNCIL MEETING IN 2022 WE PLAN

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TO MEET MAY 19 AND SEPTEMBER

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22ND FACE TO FACE AS OF NOW.

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IN 2023 WE INTEND TO HAVE A

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VIRTUAL MEETING ON JANUARY 26

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AND 27 AS WE ARE TODAY.

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AND TOMORROW AND HAVE FACE TO

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FACE MEETINGS ON MAY 25 AND

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SEPTEMBER 28TH.

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I WOULD LIKE TO POINT OUT TINA

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MORRISON FROM THE FDA ALSO

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JOINED US TODAY ON BEHALF OF

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FRANK WHITEHOLD.

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WITH THAT, I WOULD LIKE TO TURN

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IT BACK OVER THE JONI.

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-- OVER TO JONI.

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>> THANK YOU VERY MUCH.

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I WILL GET START WITH THE

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COUNCIL REPORT AND I HAVE TO SAY

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A LOT HAPPENED SINCE WE LAST

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MET, SEEMS FOUR MONTHS IS A LONG

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TIME.

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AND NOT LEAST OF WHICH OF COURSE

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IS THAT DELTA HAS COME ON SCENE,

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OFF SCENE AND NOW OMICRON IS NOW

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THE WE WE ARE DEALING WITH, I

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HOPE YOU ARE HANGING IN AND

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DOING WELL DURING THIS TIME.

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AS I GO THROUGH THE DIRECTOR'S

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REPORT PLEASE FEEL FREE TO PUT

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QUESTIONS AND COMMENTS IN THE

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CHAT AS ANNA MENTIONED, OUR

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DEPUTY DIRECTOR CLAIRE SCHMIDT

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AND ANN MIGHT BE TAG TEAM WITH

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COMMUNICATIONS EDUCATION, THEY

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WILL BE MONITORING THE

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DISCUSSION AND BE ABLE TO LOOK

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AT THE CHAT AND THE RAISED HANDS

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AND THEY WILL CALL ON YOU AT THE

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END OF THE REPORT AND HOPEFULLY

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HAVE GOOD AMOUNT OF TIME FOR

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DISCUSSION.

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PLEASE DO SO.

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FIRST I WANT TO RELAY SOME OF

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YOU MAY KNOW, NOT SURE IF

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CHRISTINA WILL BE ABLE TO MAKE

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IT TODAY, I HOPE SHE IS ON

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TODAY, SOME MAY KNOW KRISTINA

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HARTMAN IS NO LONGER AT THE

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ASSISTANCE FUND.

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THIS IS HER LAST OFFICIAL DAY ON

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OUR COUNCIL.

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SO WE ARE SAYING GOODBYE TO

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KRISTINA AND WISH HER WELL IN

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HER NEW POSITION AND HER NEW

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POSITION PRECLUDES HER SERVICE

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ON COUNCIL SO I KNOW THOUGH THAT

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WE WILL CONTINUE TO WORK WITH

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KRISTINA IN A VARIETY OF OTHER

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CAPACITIES.

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I KNOW SHE WILL CONTINUE TO

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CONTINUE TO GIVE TO THE

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SCIENTIFIC IMMUNITY, WE LOOK

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FORWARD TO WORKING WITH YOU AND

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YOUR NEW ROLE.

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>> THANK YOU, JONI.

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>> GLAD YOU MADE IT.

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NICE TO SEE YOU.

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SEVERAL NIH TRANSITION

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LEADERSHIP TOO.

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DR. COLLINS STEPPED DOWN AS

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DIRECTOR OF THE NIH.

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HE WAS THE LONGEST SERVING NIH

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DIRECTOR AND SERVED THREE

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PRESIDENTS.

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AND IN CASE YOU MISSED IT, THERE

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WAS A WONDERFUL TRIBUTE TO DR.

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COLLINS AND THE LINK IS SHOWN

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HERE BELOW.

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THERE WERE VARIETY OF FAIR WELL

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MESSAGES FROM LUMINARY

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SCIENTISTS, LIKE JANE GOODALL TO

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PRESIDENTS AND VICE PRESIDENTS

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AND POLITICIANS TO CO-MEDIANS

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AND ACTORS AND MUSICIANS.

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SO IT WAS REALLY A WONDERFUL

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EVENT SO IF YOU HAVEN'T HAD A

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CHANCE PLEASE TAKE A LOOK.

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AND AS DR. COLLINS WAS GOING

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THROUGH THIS FAIR WELL TOUR HE

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ALSO CONDUCTED AN INTERVIEW

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PUBLISHED IN JAMA, HE WAS ASKED

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ABOUT HIS TOP THREE SCIENTIFIC

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ACCOMPLISHMENTS.

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HIS RESPONSE INCLUDED THE

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FOUNDING OF NCATS AMONG THE TOP

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THREE ACCOMPLISHMENTS.  I

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CERTAINLY COULDN'T AGREE MORE,

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COULDN'T BE MORE PROUD OF THAT.

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WITH THE VISION OF HIS VISION

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FORMING NCATS AND THEN CHRIS

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AUSTIN'S LEADERSHIP THE LAST TEN

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YEARS IT IS BUILT NCATS FROM

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GROUND UP AND NOW IT HAS COME

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INTO ITS OWN.

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IT IS I THINK EXCITING FOR US TO

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BE AND I HOPE YOU ARE AS EXCITED

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AS I AM TO CONSIDER THE NEXT

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DECADE OF WHAT NCATS IS DOING

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FOR TRANSLATION SCIENCE AND RARE

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DISEASE RESEARCH AS WELL.

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SO I WANTED TO DEFINITELY CALL

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THAT OUT FOR YOU TODAY.

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THE POSITION OF DIRECTOR IS

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PRESIDENTIALLY APPOINTED AND

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ALSO SENATE CONFIRMED.

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THIS PROCESS IS WHOLLY OWNED BY

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THE WHITE HOUSE.

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NIH IS NOT INVOLVED AT ALL SO WE

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WON'T HAVE ANY EXTRA RUMORS OR

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ANY IDEAS FOR THAT MATTER.

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NO CANDIDATES TO DATE HAVE BEEN

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PUT FORWARD BUT IN THE MEANTIME,

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THE PRESIDENT HAS ASKED DR.

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LARRY TABAK TO BE ACTING NIH

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DIRECTOR AND HE SERVED AS THE

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NIH PRINCIPLE DEPUTY DIRECTOR

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WITH DR. COLLINS.

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ALONG WITH THAT DR. TARA SCHWETZ

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HAS TAKEN HIS PLACE AS ACTING

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NIH PRINCIPLE DEPUTY DIRECTOR.

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MORE TO COME AS WE HEAR NEWS AND

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WE WILL HEAR ABOUT IT AT THE

269
00:09:31,760 --> 00:09:36,920
SAME TIME SO STAY TUNED.

270
00:09:36,920 --> 00:09:38,520
OPEN SEARCHES, THE NCATS

271
00:09:38,520 --> 00:09:39,200
DIRECTOR POSITION HAS BEEN

272
00:09:39,200 --> 00:09:40,200
POSTED SINCE WE LAST MET.

273
00:09:40,200 --> 00:09:42,000
THIS ONE DOES NOT REQUIRE A

274
00:09:42,000 --> 00:09:44,000
PRESIDENTIAL APPOINTMENT OR

275
00:09:44,000 --> 00:09:45,280
SENATE CONFIRMATION.

276
00:09:45,280 --> 00:09:47,520
BUT SIMILAR TO THE NIH DIRECTOR

277
00:09:47,520 --> 00:09:50,320
POSITION THIS ONE IS ALSO NOT

278
00:09:50,320 --> 00:09:51,480
WHOLLY OWNED BY NCATS.

279
00:09:51,480 --> 00:09:54,720
THE SEARCH FOR THIS POSITION IS

280
00:09:54,720 --> 00:09:57,720
CONDUCTED BY THE NIH DIRECTORS

281
00:09:57,720 --> 00:09:58,120
OFFICE.

282
00:09:58,120 --> 00:09:59,720
THIS IS THE ANNOUNCEMENT ON THE

283
00:09:59,720 --> 00:10:01,400
SCREEN, IT APPEARED IN A NUMBER

284
00:10:01,400 --> 00:10:02,760
OF VENUES.  IT IS OPEN UNTIL THE

285
00:10:02,760 --> 00:10:04,920
END OF THIS MONTH, JANUARY 31ST

286
00:10:04,920 --> 00:10:06,800
AND SO PLEASE HELP SPREAD THE

287
00:10:06,800 --> 00:10:08,560
WORD AND WITH ANY LUCK WE'LL

288
00:10:08,560 --> 00:10:10,280
HAVE AN UPDATE IN MAY I HOPE ON

289
00:10:10,280 --> 00:10:15,800
THIS PROCESS AS WELCH FEW OTHER

290
00:10:15,800 --> 00:10:17,040
NCATS POSITIONS UNDERGOING

291
00:10:17,040 --> 00:10:17,960
TRANSITION THAT I WANT TO TELL

292
00:10:17,960 --> 00:10:18,680
YOU ABOUT.

293
00:10:18,680 --> 00:10:28,760
THE FIRST IS DR. ANTON HE'S BEEN

294
00:10:28,760 --> 00:10:30,280
IN THE ROLE FOR SEVEN YEARS AND

295
00:10:30,280 --> 00:10:32,920
HE DECIDED TO STEP DOWN TO FOCUS

296
00:10:32,920 --> 00:10:35,160
ON OTHER HATS HE WEARS IN THE N

297
00:10:35,160 --> 00:10:37,240
CATS LABS IN THE DIVISION OF

298
00:10:37,240 --> 00:10:38,440
PRE-CLINICAL INNOVATION.

299
00:10:38,440 --> 00:10:39,960
HE'S LOOKING FORWARD TO DEVOTING

300
00:10:39,960 --> 00:10:42,120
THE BULK OF TIME AT CHEMICAL

301
00:10:42,120 --> 00:10:43,000
GENOMICS BRANCH.

302
00:10:43,000 --> 00:10:44,480
WHERE HE'S BRANCH CHIEF OF THAT

303
00:10:44,480 --> 00:10:46,920
MANY THE N CATS LABS.

304
00:10:46,920 --> 00:10:50,320
BUT IN THE MEANTIME ANTON HAS

305
00:10:50,320 --> 00:10:51,920
GRACIOUSLY AGREED TO STAY ON AS

306
00:10:51,920 --> 00:10:52,920
SCIENTIFIC DIRECTOR UNTIL WE

307
00:10:52,920 --> 00:10:54,920
CONCLUDE A SEARCH.

308
00:10:54,920 --> 00:10:56,440
WITH THE NCATS DIRECTOR POSITION

309
00:10:56,440 --> 00:11:00,640
MOVING FORWARD IN PARALLEL WHICH

310
00:11:00,640 --> 00:11:03,000
HOPE TO BEGIN THE NATIONWIDE

311
00:11:03,000 --> 00:11:05,920
SEARCH FOR THE NEXT SCIENTIFIC

312
00:11:05,920 --> 00:11:07,720
DIRECTOR FOLLOWING THE, IN CATS

313
00:11:07,720 --> 00:11:09,400
SEARCH BY A FEW MONTHS.

314
00:11:09,400 --> 00:11:10,520
HOPEFULLY NOT TOO MUCH TIME.

315
00:11:10,520 --> 00:11:12,000
I I'M GRATEFUL WE WILL CONTINUE

316
00:11:12,000 --> 00:11:13,600
TO WORK WITH ANTON IN HIS ROLE

317
00:11:13,600 --> 00:11:16,360
AND HE'S BEEN REALLY A TERRIFIC

318
00:11:16,360 --> 00:11:18,360
PARTNER IN THINKING ABOUT HOW TO

319
00:11:18,360 --> 00:11:20,920
POSITION NCATS LABS GOING

320
00:11:20,920 --> 00:11:21,320
FORWARD.

321
00:11:21,320 --> 00:11:24,520
WE REMAIN IN GOOD HANDS AND

322
00:11:24,520 --> 00:11:26,200
CONGRATULATE ANTON FOR ALL THE

323
00:11:26,200 --> 00:11:28,200
WORK HE CONDUCTED MAKING THE

324
00:11:28,200 --> 00:11:29,720
NCATS LABS WHAT IT IS NOW,

325
00:11:29,720 --> 00:11:32,920
REALLY SUPERMEN SUPER.

326
00:11:32,920 --> 00:11:34,840
I CAN'T BLAME HIM FOR WANTING TO

327
00:11:34,840 --> 00:11:37,280
BACK TO THE LAB EITHER.

328
00:11:37,280 --> 00:11:39,480
WAY TO GO,ANTON.

329
00:11:39,480 --> 00:11:42,080
THANK YOU.

330
00:11:42,080 --> 00:11:51,520
LASTLY, COURTROOM ANN PARISER IS

331
00:11:51,520 --> 00:11:53,480
RETIRING, I ASKED HER TO PRESENT

332
00:11:53,480 --> 00:11:54,920
TO COUNCIL, YOU WILL HEAR HER

333
00:11:54,920 --> 00:11:55,400
PRESENTATION TOMORROW.

334
00:11:55,400 --> 00:11:58,200
I ASKED HER TO PRESENT BECAUSE

335
00:11:58,200 --> 00:12:00,080
THERE IS INCREDIBLE PROGRESS SHE

336
00:12:00,080 --> 00:12:01,640
LED FOR OFFICE OF RARE DISEASE

337
00:12:01,640 --> 00:12:03,120
RESEARCH OVER LAST FIVE YEARS,

338
00:12:03,120 --> 00:12:05,320
SHE CAME TO NCATS FROM THE FDA

339
00:12:05,320 --> 00:12:06,800
TO LEAD THIS OFFICE.

340
00:12:06,800 --> 00:12:08,480
AND SINCE SHE ARRIVED SHE

341
00:12:08,480 --> 00:12:10,040
EXPANDED THE OFFICE SHE'S LED

342
00:12:10,040 --> 00:12:11,160
WORK TO DESCRIBE AND UNDERSTAND

343
00:12:11,160 --> 00:12:12,920
THE BURDEN OF RARE DISEASES.

344
00:12:12,920 --> 00:12:16,520
AND SHE'S DEVELOPED INCREDIBLE

345
00:12:16,520 --> 00:12:18,400
RELATIONSHIPS WITH W IN THE AS

346
00:12:18,400 --> 00:12:20,640
WELL AS ACROSS THE RARE DISEASE

347
00:12:20,640 --> 00:12:22,320
BIOMEDICAL SPACE TO DRIVE ALL

348
00:12:22,320 --> 00:12:24,240
AREAS AND MOST RECENTLY LED THE

349
00:12:24,240 --> 00:12:26,120
WORK FOR NCATS ORPHAN DRUG

350
00:12:26,120 --> 00:12:27,920
STATUS FOR ONE OF THE PAT

351
00:12:27,920 --> 00:12:28,320
TRIALS.

352
00:12:28,320 --> 00:12:30,840
SO WE ARE GOING TO MISS ANN'S

353
00:12:30,840 --> 00:12:33,960
LEADERSHIP AND PASSION FOR RARE

354
00:12:33,960 --> 00:12:37,920
DISEASE RESEARCH SO WE WISH HER

355
00:12:37,920 --> 00:12:39,520
WELL IN RETIREMENT TOO.

356
00:12:39,520 --> 00:12:41,400
DR. PJ BROOKS IS WITH ANN ALONG

357
00:12:41,400 --> 00:12:42,720
THE WAY AND I HAVE ASKED HIM TO

358
00:12:42,720 --> 00:12:44,160
STEP IN AS ACTING DIRECTOR UNTIL

359
00:12:44,160 --> 00:12:45,800
A SEARCH IS COMPLETE.

360
00:12:45,800 --> 00:12:48,320
SO THEY WILL TAG TEAM TOMORROW

361
00:12:48,320 --> 00:12:50,120
FOR THEIR PRESENTATION AS SORT

362
00:12:50,120 --> 00:12:51,400
OF A WARM HAND OFF.

363
00:12:51,400 --> 00:12:54,000
AS WITH THE SCIENTIFIC DIRECTOR

364
00:12:54,000 --> 00:12:55,560
TRANSITION THAT I MENTIONED

365
00:12:55,560 --> 00:12:56,920
BEFORE, THERE WILL BE A SEARCH

366
00:12:56,920 --> 00:12:59,040
FOR NEW DIRECTOR FOR OFFICE OF

367
00:12:59,040 --> 00:13:00,640
RARE DISEASE RESEARCH AS WELL.

368
00:13:00,640 --> 00:13:03,320
THAT WILL COMMENCE RELATIVELY --

369
00:13:03,320 --> 00:13:05,320
AT SIMILAR TIME AS WE CONDUCT

370
00:13:05,320 --> 00:13:06,240
THESE OTHER SEARCHES.

371
00:13:06,240 --> 00:13:08,440
IN THE MEANTIME, WE WELCOME PJ

372
00:13:08,440 --> 00:13:10,240
IN THIS ACTING ROLE AND WE WON'T

373
00:13:10,240 --> 00:13:13,400
SKIP A BEAT WITH HIS LEADERSHIP

374
00:13:13,400 --> 00:13:17,120
THERE.

375
00:13:17,120 --> 00:13:18,680
SO THAT WAS A LOT OF PERSONNEL

376
00:13:18,680 --> 00:13:20,120
CHANGES AND THERE'S A LOT GOING

377
00:13:20,120 --> 00:13:21,800
ON WITH OTHER ANNOUNCEMENTS AND

378
00:13:21,800 --> 00:13:23,520
EVENTS I WILL RELAY.

379
00:13:23,520 --> 00:13:25,960
ALSO VERY EXCITING BECAUSE ONE

380
00:13:25,960 --> 00:13:27,600
IS TO REALLY RECOGNIZE AND

381
00:13:27,600 --> 00:13:30,120
CONGRATULATE OUR LEADERS IN THE

382
00:13:30,120 --> 00:13:32,840
NCATS AND CTSA COMMUNITY.

383
00:13:32,840 --> 00:13:40,520
SHERRY BURKIN ANDREA GARCIA, KEN

384
00:13:40,520 --> 00:13:43,720
MANDL AND LIZ MCNALLY AND KEITH

385
00:13:43,720 --> 00:13:48,200
NORRIS, AND MARCELLA SMITH, IT

386
00:13:48,200 --> 00:13:49,920
UNDERSCORES THE IMPORTANT WORK

387
00:13:49,920 --> 00:13:52,200
WE DO SO CONGRATULATIONS TO ALL

388
00:13:52,200 --> 00:13:53,240
THESE FOLKS.

389
00:13:53,240 --> 00:13:57,080
IN THE SAME VEIN, COLLEEN KELLY,

390
00:13:57,080 --> 00:14:02,520
MEGAN SRINIVAS AND CH ARKANSAS

391
00:14:02,520 --> 00:14:04,600
YANG ARE ALSO RECOGNIZED FOR

392
00:14:04,600 --> 00:14:07,560
THEIR WORK WHAT THEIR ARE DOING

393
00:14:07,560 --> 00:14:13,120
NOW, SOME SCHOLARS AND TRAININGS

394
00:14:13,120 --> 00:14:18,520
AND DR. CHAO YANG IS IN

395
00:14:18,520 --> 00:14:19,840
COMMUNITY ENGAGEMENT, SELECTED

396
00:14:19,840 --> 00:14:21,520
AS PEOPLE, 40 PEOPLE WITHIN

397
00:14:21,520 --> 00:14:23,920
THEIR CATEGORIES WHO ARE UNDER

398
00:14:23,920 --> 00:14:24,600
40.

399
00:14:24,600 --> 00:14:26,080
SO CONGRATULATIONS TO THEM, I

400
00:14:26,080 --> 00:14:28,200
THINK WE ARE DEFINITELY IN GOOD

401
00:14:28,200 --> 00:14:35,400
HANDS GOING FORWARD.

402
00:14:35,400 --> 00:14:38,080
RARE DISEASE DAY IS FEBRUARY 28,

403
00:14:38,080 --> 00:14:39,560
THE LINK AT THE BOTTOM TO

404
00:14:39,560 --> 00:14:40,960
REGISTER IF YOU HAVEN'T DONE SO

405
00:14:40,960 --> 00:14:41,200
ALREADY.

406
00:14:41,200 --> 00:14:43,560
IT IS REALLY A PACKED AGENDA,

407
00:14:43,560 --> 00:14:45,000
ADDRESSING DIVERSITY IN RARE

408
00:14:45,000 --> 00:14:48,120
DISEASE, RESEARCH INEQUITY OF

409
00:14:48,120 --> 00:14:49,920
CARE, IT IS ABOUT PERSONALIZED

410
00:14:49,920 --> 00:14:51,440
MEDICINE IMPORTANCE OF ADVOCACY

411
00:14:51,440 --> 00:14:52,640
AND COLLABORATIONS.

412
00:14:52,640 --> 00:14:55,920
NATURAL HISTORY DATA COLLECTION.

413
00:14:55,920 --> 00:14:56,840
FOR GENE THERAPY TRIALS.

414
00:14:56,840 --> 00:14:58,520
THE USE OF TELEHEALTH AND

415
00:14:58,520 --> 00:15:00,520
EFFORTS ON ADDRESSING THE

416
00:15:00,520 --> 00:15:02,000
DIAGNOSTIC ODYSSEY, THIS IS

417
00:15:02,000 --> 00:15:06,840
REALLY A I THINK A VERY EXCITING

418
00:15:06,840 --> 00:15:09,280
AGENDA WITH MEATY TOPICS REALLY

419
00:15:09,280 --> 00:15:10,840
PRIMING RELEVANT FOR WHAT WE DO

420
00:15:10,840 --> 00:15:13,800
SO HOPE YOU CAN JOIN US I

421
00:15:13,800 --> 00:15:15,920
GUARANTEE YOU THAT THIS WOULD BE

422
00:15:15,920 --> 00:15:17,480
ONE OF THE BEST MEETINGS YOU

423
00:15:17,480 --> 00:15:18,880
ATTEND ALL YEAR SO MAKE IT IF

424
00:15:18,880 --> 00:15:22,200
YOU CAN OR ALERT CUR COLLEAGUES

425
00:15:22,200 --> 00:15:34,920
AS WELL.

426
00:15:34,920 --> 00:15:37,200
SO FINALLY WE HAVE TALKED ABOUT

427
00:15:37,200 --> 00:15:40,640
ARPAH IN PREVIOUS MEETINGS.

428
00:15:40,640 --> 00:15:44,320
AND SO THIS ROUND I DECIDED DR.

429
00:15:44,320 --> 00:15:46,200
SCHWETZ IS NOW BACK TO NIH SO I

430
00:15:46,200 --> 00:15:47,760
ASKED TARA TO JOIN US TO GIVE

431
00:15:47,760 --> 00:15:51,000
UPDATE ON TOPIC OF ARPA H.

432
00:15:51,000 --> 00:15:52,520
SHE'S ACTING PRINCIPAL DEPUTY

433
00:15:52,520 --> 00:15:54,400
DIRECTOR BUT THE LAST SIX MONTHS

434
00:15:54,400 --> 00:15:55,920
SHE'S BEEN DETAILED TO THE

435
00:15:55,920 --> 00:15:58,160
OFFICE OF SCIENCE TECHNOLOGY AND

436
00:15:58,160 --> 00:15:59,320
POLICY AT OSTP.

437
00:15:59,320 --> 00:16:01,200
SHE'S WORKING VERY CLOSELY WITH

438
00:16:01,200 --> 00:16:09,600
DERRICK LANDER ON PLANNING ARPA

439
00:16:09,600 --> 00:16:12,160
H SO I WILL LET HER UPDATE.

440
00:16:12,160 --> 00:16:13,640
I DON'T WANT TO STEAL HER

441
00:16:13,640 --> 00:16:14,000
THUNDER.

442
00:16:14,000 --> 00:16:17,560
SHE WILL FOLLOW ME DIRECTLY.

443
00:16:17,560 --> 00:16:24,520
WAR PA THAT WILL BE THE NEXT
TALK.

444
00:16:24,520 --> 00:16:26,720
TO ROUND OUT I HAVE A FEW

445
00:16:26,720 --> 00:16:28,640
UPDATES ON DIVERSITY AND EQUITY

446
00:16:28,640 --> 00:16:32,960
AND INCLUSION OR DEI EFFORT AT

447
00:16:32,960 --> 00:16:34,200
NCATS AND THE NIH.

448
00:16:34,200 --> 00:16:35,920
THE NIH IS HOLDING A SERIES OF

449
00:16:35,920 --> 00:16:36,920
LISTENING SESSIONS AND I HAPPEN

450
00:16:36,920 --> 00:16:39,400
TO HOLD ONE LAST WEEK FOR THE

451
00:16:39,400 --> 00:16:41,760
HEALTH CENTERS AN SYSTEMS, AND

452
00:16:41,760 --> 00:16:43,640
THERE'S ALSO A FEW COMING UP SO

453
00:16:43,640 --> 00:16:44,680
I PUT THOSE DATES HERE SO YOU

454
00:16:44,680 --> 00:16:46,520
CAN SEE THEM BUT THERE IS A LINK

455
00:16:46,520 --> 00:16:49,400
AT THE BOTTOM THAT YOU CAN CHECK

456
00:16:49,400 --> 00:16:50,960
INTO TO SEE OTHER ACTIVITIES

457
00:16:50,960 --> 00:16:55,360
THAT ARE GOING ON IN THIS SPACE

458
00:16:55,360 --> 00:16:56,240
AND REGISTER FOR ONE OF THESE

459
00:16:56,240 --> 00:16:58,880
ACTIVITIES IF YOU ARE ABLE TO.

460
00:16:58,880 --> 00:17:00,800
ENCOURAGE YOU TO JOIN OR SEND TO

461
00:17:00,800 --> 00:17:01,800
COLLEAGUES IF THEY ARE

462
00:17:01,800 --> 00:17:02,320
INTERESTED AS WELL.

463
00:17:02,320 --> 00:17:03,920
IN ADDITION TO THE UNITE EFFORTS

464
00:17:03,920 --> 00:17:06,520
WE ARE DOING AT NCATS WE

465
00:17:06,520 --> 00:17:08,320
ESTABLISHED AN INTERNAL DEIA

466
00:17:08,320 --> 00:17:09,680
HEALTH DISPARITIES GROUP TO

467
00:17:09,680 --> 00:17:11,560
BUILD AND SUSTAIN A WELCOMING

468
00:17:11,560 --> 00:17:13,120
AND INCLUSIVE ENVIRONMENT TO

469
00:17:13,120 --> 00:17:17,520
MAKE SURE THAT OUR PROCESSES AND

470
00:17:17,520 --> 00:17:20,200
OPERATIONS ARE ALL INCLUSIVE OF

471
00:17:20,200 --> 00:17:24,320
THAT HAVE THINKING AND JUST -- I

472
00:17:24,320 --> 00:17:25,920
GUESS IT WAS OVER THE SUMMER

473
00:17:25,920 --> 00:17:28,480
PROBABLY NOW WE ARE ALSO MAKING

474
00:17:28,480 --> 00:17:29,840
SURE THESE ARE IDEAS AND TOPICS

475
00:17:29,840 --> 00:17:31,880
THAT ARE DISCUSSED AT MEETINGS

476
00:17:31,880 --> 00:17:33,920
AND CONFERENCES THAT WE SUPPORT.

477
00:17:33,920 --> 00:17:35,920
ANY TOPICS THAT CAN COVER THE

478
00:17:35,920 --> 00:17:37,600
SCIENCE NEEDS TO ALSO ADDRESS

479
00:17:37,600 --> 00:17:38,840
HEALTH EQUITY IF THERE IS AN

480
00:17:38,840 --> 00:17:44,000
OPPORTUNITY TO DO SO.

481
00:17:44,000 --> 00:17:45,920
WE ENCOURAGE TO HAPPEN IN THEK

482
00:17:45,920 --> 00:17:47,080
SCIENTIFIC OFFICE AS WELL.

483
00:17:47,080 --> 00:17:48,520
ANOTHER CTSA INVESTIGATOR

484
00:17:48,520 --> 00:17:51,640
PUBLISHED A PIECE ABOUT DEI IN

485
00:17:51,640 --> 00:17:54,920
CLINICAL TRANSITIONOR RATIONAL

486
00:17:54,920 --> 00:17:56,600
RESEARCH AND THIS PAPER I DON'T

487
00:17:56,600 --> 00:17:59,760
HAVE A LINK BUT I DID PUT THE

488
00:17:59,760 --> 00:18:00,960
TITLE ON THE SLIDE HERE.

489
00:18:00,960 --> 00:18:03,320
THIS PAPER LAYS OUT A PATH

490
00:18:03,320 --> 00:18:04,880
FORWARD AND IT ALSO REPRESENTS I

491
00:18:04,880 --> 00:18:09,200
THINK A DEEPER EFFORT WITHIN THE

492
00:18:09,200 --> 00:18:10,680
STEERING COMMITTEE AS WELL AS

493
00:18:10,680 --> 00:18:11,600
CTSA COMMUNITY AS LARGE.

494
00:18:11,600 --> 00:18:13,480
THERE IS NOW A DEI TASK FORCE

495
00:18:13,480 --> 00:18:15,320
WITHIN THE STEERING COMMITTEE OF

496
00:18:15,320 --> 00:18:18,080
THE CTSA PROGRAM.

497
00:18:18,080 --> 00:18:20,600
A LOVE OF THE EFFORTS WITH THAT

498
00:18:20,600 --> 00:18:23,320
TASK FORCE BUT ALSO PRIOR TO THE

499
00:18:23,320 --> 00:18:25,040
DEVELOPMENT OF THAT TASK FORCE

500
00:18:25,040 --> 00:18:26,880
THERE'S BEING DISCUSSIONS WITH

501
00:18:26,880 --> 00:18:27,880
CTSA PROGRAM ABOUT THIS.

502
00:18:27,880 --> 00:18:29,120
THIS PARTICULAR PAPER I THINK IS

503
00:18:29,120 --> 00:18:31,240
A CULMINATION OF LOT OF THOSE

504
00:18:31,240 --> 00:18:32,720
DISCUSSIONS THAT TALKS ABOUT

505
00:18:32,720 --> 00:18:34,360
LEADERSHIP AND TRAINING AND

506
00:18:34,360 --> 00:18:36,320
RESEARCH AND CLINICAL TRIALS AND

507
00:18:36,320 --> 00:18:38,360
PROVIDES CONCRETE GOALS THAT

508
00:18:38,360 --> 00:18:40,400
TRANSFORM AND BUILD CAPACITY AS

509
00:18:40,400 --> 00:18:41,200
WELL AS BUILD TRUST.

510
00:18:41,200 --> 00:18:43,680
SO I'M COMMITTED TO TRANSLATING

511
00:18:43,680 --> 00:18:45,320
THESE SORTS OF EFFORTS INTO

512
00:18:45,320 --> 00:18:46,120
MEASURABLE ACTION AS WE GO

513
00:18:46,120 --> 00:18:49,160
FORWARD.

514
00:18:49,160 --> 00:18:52,440
I WANT TO SPEND A FEW SECONDS ON

515
00:18:52,440 --> 00:18:54,120
THE BUDGETS NOT MUCH TO RELAY

516
00:18:54,120 --> 00:18:55,320
SINCE THE LAST MEETING

517
00:18:55,320 --> 00:18:56,000
UNFORTUNATELY.

518
00:18:56,000 --> 00:18:59,560
THE CONTINUING RESOLUTION THAT

519
00:18:59,560 --> 00:19:00,920
WAS TO DECEMBER WAS REUPPED IF

520
00:19:00,920 --> 00:19:03,600
YOU WILL, WE HAVE A CONTINUING

521
00:19:03,600 --> 00:19:06,360
RESOLUTION THROUGH FEBRUARY 18.

522
00:19:06,360 --> 00:19:07,840
JUST REMINDER THAT THE FULL

523
00:19:07,840 --> 00:19:09,640
HOUSE VOTED AND APPROVED THEIR

524
00:19:09,640 --> 00:19:11,160
APPROPRIATIONS BILLS BACK IN

525
00:19:11,160 --> 00:19:13,520
JULY AND THE SENATE -- THEY

526
00:19:13,520 --> 00:19:15,960
COULDN'T AGREE ON THE TOP LINE

527
00:19:15,960 --> 00:19:17,560
APPROPRIATION NUMBERS BUT

528
00:19:17,560 --> 00:19:19,240
MAJORITY RELEASED DRAFT BILLS IN

529
00:19:19,240 --> 00:19:21,720
REPORTS FOR PUBLIC AWARENESS ON

530
00:19:21,720 --> 00:19:24,360
I THINK THAT WAS -- YEAH,

531
00:19:24,360 --> 00:19:24,840
OCTOBER 18.

532
00:19:24,840 --> 00:19:26,240
THESE BILLS HAVEN'T BEEN

533
00:19:26,240 --> 00:19:29,320
FORMALLY INTRODUCED.

534
00:19:29,320 --> 00:19:31,080
WE ARE HOPEFUL OVER THE NEXT

535
00:19:31,080 --> 00:19:32,520
COMING WEEKS WE WILL START TO

536
00:19:32,520 --> 00:19:35,520
SEE THAT MOVEMENT AND FEBRUARY

537
00:19:35,520 --> 00:19:37,680
IS GOING TO BE A CONFUSING

538
00:19:37,680 --> 00:19:40,120
MONTH, NOT ONLY IS THAT

539
00:19:40,120 --> 00:19:42,440
HAPPENING BUT ALSO THE

540
00:19:42,440 --> 00:19:43,920
PRESIDENT'S BUDGET COMES OUT

541
00:19:43,920 --> 00:19:46,120
EVERY FEBRUARY SO THE FY 23

542
00:19:46,120 --> 00:19:48,160
BUDGET IS ANTICIPATED TO BE

543
00:19:48,160 --> 00:19:49,760
RELEASED IN EARLY FEBRUARY AS

544
00:19:49,760 --> 00:19:51,120
WELL.

545
00:19:51,120 --> 00:19:52,680
SO JUST STAY TUNED TO WHAT'S

546
00:19:52,680 --> 00:19:54,520
HAPPENING IN TERMS OF THE

547
00:19:54,520 --> 00:19:56,680
CONTINUING RESOLUTION AS WELL AS

548
00:19:56,680 --> 00:19:59,840
THE FY 22 BUDGET.

549
00:19:59,840 --> 00:20:01,440
I'M ALSO TAKING A MOMENT TO

550
00:20:01,440 --> 00:20:03,000
HIGHLIGHT SOME OF THE RESEARCH

551
00:20:03,000 --> 00:20:05,040
FUNDING OPPORTUNITIES THAT ARE

552
00:20:05,040 --> 00:20:06,000
CURRENTLY ON THE STREET.

553
00:20:06,000 --> 00:20:07,880
I WON'T WALK THROUGH ALL OF

554
00:20:07,880 --> 00:20:09,520
THESE BUT I WANTED YOU TO HAVE

555
00:20:09,520 --> 00:20:11,320
THIS LIST SO YOU WOULD BE ABLE

556
00:20:11,320 --> 00:20:13,120
TO LOOK AT THE DIFFERENT FUNDING

557
00:20:13,120 --> 00:20:13,920
ANNOUNCEMENT OPPORTUNITIES AND

558
00:20:13,920 --> 00:20:16,160
THE TITLES, IT REALLY HIGHLIGHTS

559
00:20:16,160 --> 00:20:17,840
THE BREADTH OF ACTIVITIES THAT

560
00:20:17,840 --> 00:20:18,960
WE ARE INVOLVED IN AND HOPE YOU

561
00:20:18,960 --> 00:20:23,040
AND COLLEAGUES CAN SPREAD THE

562
00:20:23,040 --> 00:20:24,640
WORD OR APPLY TO THESE

563
00:20:24,640 --> 00:20:26,120
ACTIVITIES.

564
00:20:26,120 --> 00:20:28,920
SO I WANT TO MOVE ON TO THE MORE

565
00:20:28,920 --> 00:20:30,920
SCIENCE PORTION OF MY REPORT AND

566
00:20:30,920 --> 00:20:33,120
WILL IS A LOT TO RELAY HERE BUT

567
00:20:33,120 --> 00:20:35,480
WANT TO GIVE A HEADS UP ON OTHER

568
00:20:35,480 --> 00:20:37,240
THINGS THAT WILL BE GIVING YOU

569
00:20:37,240 --> 00:20:40,520
UPDATES ON AS WE GO FORWARD.

570
00:20:40,520 --> 00:20:43,000
VALERIE GORDON WILL TALK ABOUT

571
00:20:43,000 --> 00:20:45,920
INCLUSION MONITORING REPORTS.

572
00:20:45,920 --> 00:20:47,360
THIS IS A REQUIREMENT FOR US TO

573
00:20:47,360 --> 00:20:51,560
RELAY TO YOU ON A, IT IS NOT A

574
00:20:51,560 --> 00:20:53,000
ROUTINE BASIS BUT IT IS A

575
00:20:53,000 --> 00:20:54,800
ROUTINE BASIS BUT NOT FREQUENT

576
00:20:54,800 --> 00:20:55,240
BASIS.

577
00:20:55,240 --> 00:20:56,480
SO SHE WILL TELL YOU ABOUT THAT

578
00:20:56,480 --> 00:20:57,480
REPORT AND WHY IT IS IMPORTANT

579
00:20:57,480 --> 00:21:02,040
THAT WE GET YOUR INPUT ON THAT.

580
00:21:02,040 --> 00:21:05,040
THEN AFTER VALERIE GOES LILY

581
00:21:05,040 --> 00:21:06,360
PORTILLA FROM OFFICE OF

582
00:21:06,360 --> 00:21:07,760
STRATEGIC ALLIANCE WHO WILL

583
00:21:07,760 --> 00:21:10,160
UPDATE ON ACTIVITIES IN HER

584
00:21:10,160 --> 00:21:12,280
OFFICE AND THEN AS I MENTIONED

585
00:21:12,280 --> 00:21:15,600
ANN AND PJ WILL BE TALKING ABOUT

586
00:21:15,600 --> 00:21:16,520
ACTIVITIES AROUND RARE DISEASE

587
00:21:16,520 --> 00:21:23,240
SPACE TOO.

588
00:21:23,240 --> 00:21:24,040
FINALLY KEITH WILL BE TALKING

589
00:21:24,040 --> 00:21:25,880
ABOUT A NEW APPROACH WE ARE TAKE

590
00:21:25,880 --> 00:21:27,320
FOGGER OUR ORGANIZATION OF

591
00:21:27,320 --> 00:21:29,440
NCATS, THAT IS ALSO SOMETHING WE

592
00:21:29,440 --> 00:21:31,320
NEED TO RELAY SO HE WILL TELL

593
00:21:31,320 --> 00:21:34,040
YOU ABOUT THAT MORE TOWARDS THE

594
00:21:34,040 --> 00:21:38,960
END.

595
00:21:38,960 --> 00:21:40,720
NOW I WANT TO DIVE INTO THE

596
00:21:40,720 --> 00:21:42,120
RESEARCH EFFORTS WE HAVE BEEN

597
00:21:42,120 --> 00:21:44,120
DOING.

598
00:21:44,120 --> 00:21:46,680
BEFORE I I SHOULD SAY BECAUSE OF

599
00:21:46,680 --> 00:21:48,200
THE NATURE OF NCATS OUR TEAM

600
00:21:48,200 --> 00:21:50,320
BASED APPROACH, OUR FOCUS ON

601
00:21:50,320 --> 00:21:53,360
PLATFORM TECHNOLOGIES, APPROACH

602
00:21:53,360 --> 00:21:55,280
ON RARE DISEASE AUTOMATION AND

603
00:21:55,280 --> 00:21:57,080
ROBOTICS ACTIVITIES EMPHASIS ON

604
00:21:57,080 --> 00:21:58,640
DATA SCIENCE AND OUR -- ALL HE

605
00:21:58,640 --> 00:22:00,000
IS LEAD TO OUR ABILITY TO

606
00:22:00,000 --> 00:22:02,560
RESPOND TO PUBLIC HEALTH

607
00:22:02,560 --> 00:22:03,800
EMERGENCIES, AND GET INVOLVED IN

608
00:22:03,800 --> 00:22:04,600
VARIETY OF DISEASE RELATED

609
00:22:04,600 --> 00:22:07,360
ACTIVES BUT CERTAINLY OVER THE

610
00:22:07,360 --> 00:22:09,840
LAST COUPLE OF YEARS IT HAS BEEN

611
00:22:09,840 --> 00:22:12,160
FOCUSED ON THIS -- THE COVID

612
00:22:12,160 --> 00:22:13,520
PUBLIC HEALTH EMERGENCY.

613
00:22:13,520 --> 00:22:16,720
ALL OF WHAT WE CAN BRING TO THE

614
00:22:16,720 --> 00:22:17,400
TABLE ARE QUINTESSENTIALLY NCATS

615
00:22:17,400 --> 00:22:21,520
SO I WILL GIVE YOU A SLIVER OF

616
00:22:21,520 --> 00:22:23,200
THE LARGER PIE OF ACTIVITIES WE

617
00:22:23,200 --> 00:22:25,000
DO NOW BECAUSE OF THE COVID

618
00:22:25,000 --> 00:22:26,520
RELATIONSHIP TO THOSE ACTIVITIES

619
00:22:26,520 --> 00:22:31,320
BUT IT DOES JUST REPRESENT A

620
00:22:31,320 --> 00:22:31,920
PIECE SLIVER OF WHAT WE ARE

621
00:22:31,920 --> 00:22:32,360
DOING.

622
00:22:32,360 --> 00:22:35,160
I WILL TELL YOU PROGRESS ON THE

623
00:22:35,160 --> 00:22:36,440
COVID WORK -- COVERING A VARIETY

624
00:22:36,440 --> 00:22:38,800
OF AREAS BUT WILL START WITH THE

625
00:22:38,800 --> 00:22:40,320
CLINICAL TRIALS AND THEN MOVE

626
00:22:40,320 --> 00:22:41,920
INTO THE ANTIVIRAL PROGRAM ON

627
00:22:41,920 --> 00:22:44,800
PANDEMICS AND DIVE INTO OUR

628
00:22:44,800 --> 00:22:45,880
ELECTRONIC HEALTH RECORD

629
00:22:45,880 --> 00:22:47,840
NATIONAL COVID COHORT

630
00:22:47,840 --> 00:22:48,800
COLLABORATIVE ACTIVITIES.

631
00:22:48,800 --> 00:22:50,880
THEN AT THE END OF THE TALK JUST

632
00:22:50,880 --> 00:22:52,400
GIVE YOU A FAIR WARNING, AT THE

633
00:22:52,400 --> 00:22:54,120
END OF THE TALK I WANT TO SWITCH

634
00:22:54,120 --> 00:22:55,720
GEARS THE LAST TEN OR SO MINUTES

635
00:22:55,720 --> 00:22:58,400
TO WALK THROUGH SOME HIGH LEVEL

636
00:22:58,400 --> 00:23:00,320
GOALS AND I WANT TO TACKLE OVER

637
00:23:00,320 --> 00:23:06,800
THE NEXT DECADE AND WITH WHAT I

638
00:23:06,800 --> 00:23:09,000
PRESENT TODAY I HOPE IT SERVE AS

639
00:23:09,000 --> 00:23:09,760
BROAD RANGE OF SCIENTIFIC

640
00:23:09,760 --> 00:23:11,440
PURSUIT AND THE GOALS OUTLINED

641
00:23:11,440 --> 00:23:12,760
EMBRACE THAT APPROACH AND WILL

642
00:23:12,760 --> 00:23:14,120
SERVE TO HELP DRIVE THAT SUCCESS

643
00:23:14,120 --> 00:23:18,200
AS WE GO FORWARD.

644
00:23:18,200 --> 00:23:21,360
SO FIRST UP OF COURSE IS THE --

645
00:23:21,360 --> 00:23:22,160
I MENTION CLINICAL TRIALS.

646
00:23:22,160 --> 00:23:25,160
THE CTSA PROGRAM AGAIN HAS BEEN

647
00:23:25,160 --> 00:23:25,880
DOING THE LION'S SHARE OF THE

648
00:23:25,880 --> 00:23:27,000
COVID CLINICAL TRIAL WORK

649
00:23:27,000 --> 00:23:28,200
THROUGH THE ACTIVE PROGRAM THAT

650
00:23:28,200 --> 00:23:30,480
WE HAVE THROUGH THE FNIH AS WELL

651
00:23:30,480 --> 00:23:33,720
AS THE NIH AND VARIETY OF

652
00:23:33,720 --> 00:23:34,640
PRIVATE PARTNERS.

653
00:23:34,640 --> 00:23:38,800
WITH THIS PUBLIC PRIVATE PARTNER

654
00:23:38,800 --> 00:23:40,080
FRAMEWORK WE HAVE -- WE HAVE

655
00:23:40,080 --> 00:23:42,240
DONE A VARIETY OF CLINICAL

656
00:23:42,240 --> 00:23:43,440
TRIALS AND SOME OF THEM HAVE

657
00:23:43,440 --> 00:23:46,560
BEEN NCATS WHOLLY SUPPORTED LIKE

658
00:23:46,560 --> 00:23:48,040
THE CONVALESCENT PLASMA TRIALS

659
00:23:48,040 --> 00:23:49,280
BUT SOME THROUGH THE PUBLIC

660
00:23:49,280 --> 00:23:50,640
PRIVATE PARTNERSHIP THAT NCATS

661
00:23:50,640 --> 00:23:54,280
HAS SPONSORED.

662
00:23:54,280 --> 00:23:56,560
MOST MONEY COMING ARE NOT NCATS

663
00:23:56,560 --> 00:24:00,120
DOLLARS, THESE ARE DOLLARS

664
00:24:00,120 --> 00:24:00,600
(INAUDIBLE) RESPONSE.

665
00:24:00,600 --> 00:24:03,720
I'M GOING TO TALK ABOUT THE

666
00:24:03,720 --> 00:24:04,960
CONVALESCENT PLASMA TRIALS,

667
00:24:04,960 --> 00:24:07,200
THERE'S EARLY WORK COMING OUT, A

668
00:24:07,200 --> 00:24:08,840
BIGGER STORY TO TELL THAT WE

669
00:24:08,840 --> 00:24:10,880
WILL HEAR MORE OVER THE NEXT

670
00:24:10,880 --> 00:24:12,760
COMING MONTHS BUT THERE'S ONE

671
00:24:12,760 --> 00:24:13,720
REPORT OUT THAT I CAN TALK ABOUT

672
00:24:13,720 --> 00:24:16,320
RELATED TO THE CONTAIN TRIAL.

673
00:24:16,320 --> 00:24:17,920
I'M TALKING ABOUT SOME OF THE

674
00:24:17,920 --> 00:24:19,920
OTHER ACTIVITIES TOO.

675
00:24:19,920 --> 00:24:24,720
TESTIFY CONTAIN STUDY IS LOOKING

676
00:24:24,720 --> 00:24:26,920
AT EFFICACY OF COVID-19

677
00:24:26,920 --> 00:24:28,920
CONVALESCENT PLASMA IN

678
00:24:28,920 --> 00:24:29,760
HOSPITALIZED PATIENTS.

679
00:24:29,760 --> 00:24:31,600
THIS IS OUT OF THE NEW YORK

680
00:24:31,600 --> 00:24:33,720
UNIVERSITY AND CTSA HUBS AND

681
00:24:33,720 --> 00:24:35,120
AFFILIATES WITH THEM.

682
00:24:35,120 --> 00:24:37,240
AND THE TOP LINE IS THAT

683
00:24:37,240 --> 00:24:38,800
CONVALESCENT PLASMA DID NOT MEET

684
00:24:38,800 --> 00:24:40,920
THE PRE-SPECIFIED CRITERIA FOR

685
00:24:40,920 --> 00:24:43,680
EFFICACY IN THIS STUDY.

686
00:24:43,680 --> 00:24:45,560
THEY WERE USING THE HUE SCORE

687
00:24:45,560 --> 00:24:48,440
FOR SEVERITY, 11 POINT SCALE

688
00:24:48,440 --> 00:24:50,840
WHERE 0 IS ASYMPTOMATIC AND 10

689
00:24:50,840 --> 00:24:53,280
IS DEATH.

690
00:24:53,280 --> 00:24:55,320
AND THIS GRAPH HERE SHOWS

691
00:24:55,320 --> 00:24:58,320
THERE'S ODDS RATIOS POST TIER

692
00:24:58,320 --> 00:25:00,400
YEAR PROBABILITY ANALYSIS SO

693
00:25:00,400 --> 00:25:02,080
THAT RED LINE THERE IN THE

694
00:25:02,080 --> 00:25:03,720
MIDDLE IF YOU ARE TO THE LEFT OF

695
00:25:03,720 --> 00:25:04,960
THAT LINE THAT SHOWS A LITTLE

696
00:25:04,960 --> 00:25:07,640
BIT MORE BENEFIT, BUT FOR THIS

697
00:25:07,640 --> 00:25:09,560
THERE'S NO SIGNIFICANT BENEFIT

698
00:25:09,560 --> 00:25:11,240
THAT IS INDICATED IN GENERAL

699
00:25:11,240 --> 00:25:13,920
WITH CONVALESCENT PLASMA.

700
00:25:13,920 --> 00:25:16,920
BUT WHAT WAS INTERESTING IS WHAT

701
00:25:16,920 --> 00:25:18,400
THEY FOUND WHEN THEY DID

702
00:25:18,400 --> 00:25:20,320
SUBGROUP ANALYSIS IS THAT EARLY

703
00:25:20,320 --> 00:25:21,560
IN THE PANDEMIC WHEN THERE WERE

704
00:25:21,560 --> 00:25:23,720
NO TREATMENTS, IT SHOWED SOME

705
00:25:23,720 --> 00:25:24,880
EFFECTIVENESS IN THAT SUBGROUP

706
00:25:24,880 --> 00:25:27,880
ANALYSIS.

707
00:25:27,880 --> 00:25:30,160
HOWEVER, AS REMDESIVIR AND

708
00:25:30,160 --> 00:25:31,960
CORTICAL STEROIDS AND OTHER

709
00:25:31,960 --> 00:25:33,240
TYPES OF TREATMENT VACCINES ARE

710
00:25:33,240 --> 00:25:36,120
ON THE SCENE, IT HAS -- IT HAS

711
00:25:36,120 --> 00:25:37,720
WANED IN THAT BENEFIT SO THERE'S

712
00:25:37,720 --> 00:25:40,600
NO LONGER REALLY A BENEFIT FOR

713
00:25:40,600 --> 00:25:42,000
CONVALESCENT PLASMA THAT WE ARE

714
00:25:42,000 --> 00:25:44,920
SEEING NOW.

715
00:25:44,920 --> 00:25:46,680
THE CONVALESCENT PLASMA STORY

716
00:25:46,680 --> 00:25:48,320
ISN'T DONE YET SO KEEP YOUR EYE

717
00:25:48,320 --> 00:25:49,920
OUT FOR OTHER REPORTS COMING

718
00:25:49,920 --> 00:25:51,880
SOON FROM THE WORK WE SUPPORTED

719
00:25:51,880 --> 00:25:55,480
AS WELL.

720
00:25:55,480 --> 00:25:57,080
AS WELL AS OTHERS.

721
00:25:57,080 --> 00:25:58,960
ACTIVE ONE ENDED ENROLLMENT WITH

722
00:25:58,960 --> 00:26:02,400
THE LAST PATIENT FOLLOW-UPS THAT

723
00:26:02,400 --> 00:26:04,360
WILL HAPPEN IN FEBRUARY AND

724
00:26:04,360 --> 00:26:05,080
MARCH.

725
00:26:05,080 --> 00:26:09,240
THIS ACTIVE ONE STUDY LED BY

726
00:26:09,240 --> 00:26:10,720
BILL WASHINGTON UNIVERSITY ST.

727
00:26:10,720 --> 00:26:14,320
LOUIS CTSA ALONG WITH 30 OTHER

728
00:26:14,320 --> 00:26:15,560
CTSA SITES INVOLVED WITH OTHER

729
00:26:15,560 --> 00:26:16,240
SITES TOO.

730
00:26:16,240 --> 00:26:18,920
THIS IS A DOUBLE BLIND PLACEBO

731
00:26:18,920 --> 00:26:20,360
CONTROL TRIAL AND HOSPITALIZED

732
00:26:20,360 --> 00:26:24,600
PATIENTS WITH RANDOMIZED ACROSS

733
00:26:24,600 --> 00:26:26,480
THREE DIFFERENT

734
00:26:26,480 --> 00:26:27,160
IMMUNOMODULATORS.

735
00:26:27,160 --> 00:26:36,880
SENATE P -- SENEPIVEROC ENDED

736
00:26:36,880 --> 00:26:38,520
EARLY BUT TOP LINE RESULTS DID

737
00:26:38,520 --> 00:26:40,440
COMPLETE ENROLLMENT AND WE WILL

738
00:26:40,440 --> 00:26:42,200
BE HEARING MORE ABOUT THESE

739
00:26:42,200 --> 00:26:45,320
AROUND MAY OR SO WHEN WE GOT TO

740
00:26:45,320 --> 00:26:46,560
GET THAT DATA AND ANALYSIS

741
00:26:46,560 --> 00:26:49,480
COMPLETED.

742
00:26:49,480 --> 00:26:50,720
STAY TUNED IN MAY, HOPEFULLY

743
00:26:50,720 --> 00:26:55,240
WE'LL UPDATE THEN.

744
00:26:55,240 --> 00:27:00,640
ACTIVE 6 IS LED BY DUKE AND DCRI

745
00:27:00,640 --> 00:27:01,800
AS WELL AS VANDERBILT AS

746
00:27:01,800 --> 00:27:03,280
COORDINATING CENTER.

747
00:27:03,280 --> 00:27:05,600
IT IS AN OUTPATIENT TRIAL TO

748
00:27:05,600 --> 00:27:07,120
TEST EXISTING DRUGS APPROVED FOR

749
00:27:07,120 --> 00:27:08,480
OTHER INDICATIONS TO SEE IF THEY

750
00:27:08,480 --> 00:27:10,320
WERE BE REPURPOSED FOR COVID-19

751
00:27:10,320 --> 00:27:13,080
SYMPTOM RELIEF.

752
00:27:13,080 --> 00:27:15,280
THIS PARTICULAR CLINICAL TRIAL

753
00:27:15,280 --> 00:27:19,240
IS LOOKING AT THREE MAIN DRUGS,

754
00:27:19,240 --> 00:27:24,320
IVERMECTIN AND FLUVOXAMINE.

755
00:27:24,320 --> 00:27:25,800
WE ARE SENDING THESE MEDICATIONS

756
00:27:25,800 --> 00:27:28,160
TO PATIENT HOME AND DO FOLLOW-UP

757
00:27:28,160 --> 00:27:29,400
ONLINE OR THROUGH TELEPHONE

758
00:27:29,400 --> 00:27:33,040
SURVEYS SO IT IS A UNIQUE TRIAL

759
00:27:33,040 --> 00:27:35,880
WITHIN THE ACTIVE PARTNERSHIP.

760
00:27:35,880 --> 00:27:37,760
BUT IT IS GOING VERY WELL AND

761
00:27:37,760 --> 00:27:39,120
TARGETED ENROLLMENT SHOULD BE

762
00:27:39,120 --> 00:27:42,760
MET BY END OF MAY, SORRY BY END

763
00:27:42,760 --> 00:27:45,360
OF I GUESS I'LL SAY SPRING,

764
00:27:45,360 --> 00:27:46,320
PROBABLY MARCH, APRIL MORE

765
00:27:46,320 --> 00:27:50,960
LIKELY.

766
00:27:50,960 --> 00:27:52,640
AND HOPEFULLY WE'LL BE ABLE TO

767
00:27:52,640 --> 00:27:56,560
GIVE MORE DETAILS ON THIS

768
00:27:56,560 --> 00:27:58,960
ACTIVITY IN OUR MAY COUNCIL.

769
00:27:58,960 --> 00:28:01,840
WE ARE ALSO RAMPING UP OUR

770
00:28:01,840 --> 00:28:02,880
ANTIVIRAL PROGRAM FOR PANDEMICS.

771
00:28:02,880 --> 00:28:05,960
THIS IS A COLLABORATION WITH M

772
00:28:05,960 --> 00:28:09,160
CATS, NIAID, AND BARTA AND THIS

773
00:28:09,160 --> 00:28:12,560
IS TO CREATE PHASE 2 TRIAL READY

774
00:28:12,560 --> 00:28:14,480
ANTIVIRALS FOR RAPID PANDEMIC

775
00:28:14,480 --> 00:28:17,960
RESPONSE SO THEY WILL GET

776
00:28:17,960 --> 00:28:20,120
THROUGH CERTAINLY AT LEAST PHASE

777
00:28:20,120 --> 00:28:22,440
2 AND BE READY OR GET THROUGH

778
00:28:22,440 --> 00:28:24,320
PHASE 1 AND BE READY FOR PHASE 2

779
00:28:24,320 --> 00:28:29,120
IN CASE THERE IS ANOTHER NEED

780
00:28:29,120 --> 00:28:30,280
FOR A PANDEMIC RESPONSE.

781
00:28:30,280 --> 00:28:33,840
WE HAVE DONE SURVEY OF VIRAL

782
00:28:33,840 --> 00:28:35,400
FAMILIES AND ESSENTIALLY SEVEN

783
00:28:35,400 --> 00:28:37,720
VIRAL FAMILIES THOUGHT TO BE OF

784
00:28:37,720 --> 00:28:39,520
THE HIGHEST FOR PANDEMIC

785
00:28:39,520 --> 00:28:42,520
POTENTIAL.

786
00:28:42,520 --> 00:28:43,760
SO THOSE ARE SHOWN HERE ON THE

787
00:28:43,760 --> 00:28:44,280
LEFT.

788
00:28:44,280 --> 00:28:45,320
GIVEN WE ARE CURRENTLY IN THE

789
00:28:45,320 --> 00:28:46,520
PANDEMIC OF THE CORONA VIRUS

790
00:28:46,520 --> 00:28:50,720
FAMILY, MOST OF THE WORK WE DO

791
00:28:50,720 --> 00:28:52,320
CURRENTLY IS RELATED TO CORONA

792
00:28:52,320 --> 00:28:52,520
VIRUS.

793
00:28:52,520 --> 00:28:56,560
SOME OF THE PROJECTS DOING TO

794
00:28:56,560 --> 00:28:58,760
DATE, ARE LISTED HERE WITH CLEAR

795
00:28:58,760 --> 00:29:03,040
CREEK BIO COLUMBIA UNIVERSITY

796
00:29:03,040 --> 00:29:04,040
AND NCATS SUPPORTING THESE

797
00:29:04,040 --> 00:29:04,640
ACTIVITIES AS WELL.

798
00:29:04,640 --> 00:29:08,600
WE ARE LOOKING AT THINGS LIKE

799
00:29:08,600 --> 00:29:11,280
PROTEASE INHIBITORS TO STOP

800
00:29:11,280 --> 00:29:15,440
VIRAL REPLICATION WAY TO STOP

801
00:29:15,440 --> 00:29:17,000
VIRAL REPLICATION AND

802
00:29:17,000 --> 00:29:17,360
INFECTIVITY.

803
00:29:17,360 --> 00:29:20,200
WE ARE ALSO LOOKING AT COUPLE OF

804
00:29:20,200 --> 00:29:23,120
ANALOGS RNA DEPENDENT RNA

805
00:29:23,120 --> 00:29:25,400
POLYMERASES, AND THESE SORTS OF

806
00:29:25,400 --> 00:29:27,280
INHIBITORS TO ALSO HELP PREVENT

807
00:29:27,280 --> 00:29:30,160
VIRAL REPLICATION.

808
00:29:30,160 --> 00:29:31,320
SO THESE ARE SOME OF THE

809
00:29:31,320 --> 00:29:37,240
PROJECTS IN THE WAY IN OUR NCATS

810
00:29:37,240 --> 00:29:38,600
LABS IS LEADING THIS EFFORT FOR

811
00:29:38,600 --> 00:29:40,640
NCATS.

812
00:29:40,640 --> 00:29:42,680
WE HAVE A GREAT TEAM PUSHING

813
00:29:42,680 --> 00:29:45,200
REALLY A LOT OF HE IS SORTS OF

814
00:29:45,200 --> 00:29:46,600
ACTIVITIES -- THESE SORTS OF

815
00:29:46,600 --> 00:29:48,160
ACTIVITIES AND WE ARE OPEN FOR

816
00:29:48,160 --> 00:29:50,040
BUSINESS SO ANY IDEAS ALONG THE

817
00:29:50,040 --> 00:29:51,720
WAY, WE ARE HAPPY TO HEAR ABOUT

818
00:29:51,720 --> 00:29:52,240
THEM.

819
00:29:52,240 --> 00:29:53,000
EXCITING STUFF AS THIS IS

820
00:29:53,000 --> 00:29:56,480
GETTING OFF THE GROUND.

821
00:29:56,480 --> 00:29:58,920
SO I WANT TO ALSO JUST SHOW YOU

822
00:29:58,920 --> 00:29:59,960
SOME OTHER ACTIVITIES THAT WE

823
00:29:59,960 --> 00:30:03,280
ARE DOING IN TERMS OF MAKING

824
00:30:03,280 --> 00:30:04,840
SURE DATA ARE READILY ACCESSIBLE

825
00:30:04,840 --> 00:30:07,720
AND AVAILABLE FOR SCIENTISTS AND

826
00:30:07,720 --> 00:30:10,640
RESEARCHERS AND OTHERS.

827
00:30:10,640 --> 00:30:13,720
WE ARE LEADING THIS EFFORT WITH

828
00:30:13,720 --> 00:30:15,160
THE ACTIVE GROUPS TO FOLLOW ALL

829
00:30:15,160 --> 00:30:16,880
THE ACTIVE RELATED ACTIVITIES

830
00:30:16,880 --> 00:30:18,000
AND VACCINES AND THERAPEUTICS.

831
00:30:18,000 --> 00:30:21,040
AND THIS IS SORT OF A ONE PLACE

832
00:30:21,040 --> 00:30:23,120
WE CAN GO TO EASY TO READ DATA

833
00:30:23,120 --> 00:30:26,520
IN THIS OPEN DATA PORTAL.

834
00:30:26,520 --> 00:30:29,520
IT IS ON OUR NCATS WEBSITE.

835
00:30:29,520 --> 00:30:31,880
IT IS -- SO JUST TO ORIENT YOU

836
00:30:31,880 --> 00:30:33,960
AT THE TOP CORNER WITH ALL THOSE

837
00:30:33,960 --> 00:30:35,400
LITTLE DOTS THAT ARE DIFFERENT

838
00:30:35,400 --> 00:30:36,520
COLORS THOSE REPRESENT THE

839
00:30:36,520 --> 00:30:37,920
DIFFERENT WAVES OF THE DIFFERENT

840
00:30:37,920 --> 00:30:40,840
VARIANTS OF THE VIRUS.

841
00:30:40,840 --> 00:30:42,640
ON THE LEFT-HAND SIDE, ALL THAT

842
00:30:42,640 --> 00:30:46,160
IS REALLY REPRESENTING JUST THE

843
00:30:46,160 --> 00:30:47,640
OMICRON WAVE DATA.

844
00:30:47,640 --> 00:30:50,760
SO ALL THE DATA WE COLLECTED AS

845
00:30:50,760 --> 00:30:52,480
OMICRON HAS COME ON TO SCENE AS

846
00:30:52,480 --> 00:30:55,120
RELATES TO THE VACCINES AND THE

847
00:30:55,120 --> 00:30:56,920
DIFFERENT MOAN:AL ANTIBODIES AS

848
00:30:56,920 --> 00:30:58,480
WELL AS OTHER THERAPEUTICS.

849
00:30:58,480 --> 00:31:00,240
SO ALL THOSE DOTS THERE ON THE

850
00:31:00,240 --> 00:31:02,760
RIGHT HAND SIDE INDICATE THAT

851
00:31:02,760 --> 00:31:04,680
ACTIVITY IS WANED BUT IF THE DOT

852
00:31:04,680 --> 00:31:07,120
IS COLORED ON THE LEFT-HAND

853
00:31:07,120 --> 00:31:08,640
SIDE, THAT MEANS NO REDUCTION IN

854
00:31:08,640 --> 00:31:11,120
BENEFIT AND THOSE ARE ACTUALLY

855
00:31:11,120 --> 00:31:13,200
VIABLE CANDIDATES FOR

856
00:31:13,200 --> 00:31:15,320
THERAPEUTICS TO HELP THE OMICRON

857
00:31:15,320 --> 00:31:16,400
PIECE OF THE PANDEMIC.

858
00:31:16,400 --> 00:31:18,760
ON THE RIGHT HAND SIDE SHOWS THE

859
00:31:18,760 --> 00:31:20,720
DIFFERENT KINDS OF ASSAYS THAT

860
00:31:20,720 --> 00:31:23,920
WE CONDUCT TO SHOW THIS

861
00:31:23,920 --> 00:31:25,280
VIABILITY EFFICACY, THESE TYPES

862
00:31:25,280 --> 00:31:25,960
OF MEDICATIONS.

863
00:31:25,960 --> 00:31:28,240
SO IT IS REALLY A GREAT RESOURCE

864
00:31:28,240 --> 00:31:31,000
TO LOOK, NOT JUST AT CURRENT

865
00:31:31,000 --> 00:31:32,480
RATE BUT ALSO THE OTHER WAVES TO

866
00:31:32,480 --> 00:31:34,040
SEE THE DIFFERENCES AND WHY IT

867
00:31:34,040 --> 00:31:39,000
IS VERY IMPORTANT WE HAVE THIS

868
00:31:39,000 --> 00:31:41,960
LARGE THERAPEUTICS PROGRAM, THAT

869
00:31:41,960 --> 00:31:44,480
IS HELPFUL AS WE MOVE FORWARD IN

870
00:31:44,480 --> 00:31:46,520
THIS PANDEMIC WHICH IT IS -- I

871
00:31:46,520 --> 00:31:47,920
DON'T KNOW THAT ANY OF US COULD

872
00:31:47,920 --> 00:31:50,080
HAVE PREDICTED IT WOULD BE HERE

873
00:31:50,080 --> 00:31:52,320
TODAY WHERE WE ARE SO I HOPE WE

874
00:31:52,320 --> 00:31:55,240
CAN CONTINUE TO MAKE THESE

875
00:31:55,240 --> 00:31:56,400
THINGS AVAILABLE AND CONTINUE

876
00:31:56,400 --> 00:31:59,720
THE ACTIVITIES GOING FORWARD.

877
00:31:59,720 --> 00:32:03,120
THE OTHER MAJOR AREA IS AS I

878
00:32:03,120 --> 00:32:04,800
TALKED BEFORE IS MAKING

879
00:32:04,800 --> 00:32:05,840
ELECTRONIC HEALTH RECORD

880
00:32:05,840 --> 00:32:06,640
INFORMATION AVAILABLE FOR

881
00:32:06,640 --> 00:32:08,040
STUDYING COVID-19.

882
00:32:08,040 --> 00:32:12,320
THIS IS A PARTNERSHIP WITH THE

883
00:32:12,320 --> 00:32:15,040
SAVE PROGRAM 2H ALONG WITH

884
00:32:15,040 --> 00:32:15,920
NATIONAL INSTITUTE ON GENERAL

885
00:32:15,920 --> 00:32:19,120
MEDICAL SCIENCES AND THE IDEA

886
00:32:19,120 --> 00:32:20,520
CLINICAL RESEARCH PROGRAM AS

887
00:32:20,520 --> 00:32:22,560
WELL AS NON-PROFIT HEALTH IT

888
00:32:22,560 --> 00:32:23,560
ORGANIZATION WORKING TO IMPROVE

889
00:32:23,560 --> 00:32:25,080
HEALTH EQUITY.

890
00:32:25,080 --> 00:32:27,280
NCATS IS JOINED UP WITH OTHER

891
00:32:27,280 --> 00:32:30,160
FEDERAL AGENCIES AS WELL FOR

892
00:32:30,160 --> 00:32:32,120
EXAMPLE THE FDA, OFFICE OF

893
00:32:32,120 --> 00:32:34,800
NATIONAL COORDINATOR FOR HEALTH

894
00:32:34,800 --> 00:32:35,720
INFORMATION AND TECHNOLOGY AS

895
00:32:35,720 --> 00:32:39,280
WELL AS BRTA AND A FEW OTHERS.

896
00:32:39,280 --> 00:32:41,800
TO DATE, THERE ARE NOW OVER 10

897
00:32:41,800 --> 00:32:43,280
MILLION ELECTRONIC HEALTH

898
00:32:43,280 --> 00:32:46,320
RECORDS WITHIN THE DATA SET WITH

899
00:32:46,320 --> 00:32:47,400
3.7 MILLION REPRESENTED COVID

900
00:32:47,400 --> 00:32:50,320
POSITIVE CASES.

901
00:32:50,320 --> 00:32:52,080
OVER 12 BILLION ROWS OF DATA

902
00:32:52,080 --> 00:32:53,600
WITH ENTIRE COMMUNITY WHO IS

903
00:32:53,600 --> 00:32:55,440
MAKING HEADWAY ON ORGANIZING AND

904
00:32:55,440 --> 00:32:56,560
ANALYZING THIS DATA.

905
00:32:56,560 --> 00:32:58,280
AND THERE IS A DASHBOARD HERE AT

906
00:32:58,280 --> 00:33:00,400
THE BOTTOM, A LINK THERE YOU CAN

907
00:33:00,400 --> 00:33:02,720
GO TO NCATS DASHBOARD AND YOU

908
00:33:02,720 --> 00:33:04,640
CAN SEE THIS DATA COLLECTED.

909
00:33:04,640 --> 00:33:06,680
BUT AS I MENTION 12 BILLION ROWS

910
00:33:06,680 --> 00:33:08,400
OF DATA SO THINK ABOUT THAT ROWS

911
00:33:08,400 --> 00:33:10,920
OF DATA, AND IF YOU RUN THE

912
00:33:10,920 --> 00:33:12,080
SPREADSHEET AND PRINT OUT THAT

913
00:33:12,080 --> 00:33:15,320
SPREADSHEET AND YOU THINK ABOUT

914
00:33:15,320 --> 00:33:18,920
EACH CELL IN A ROW IS PROBABLY

915
00:33:18,920 --> 00:33:20,560
AN INCH, THE AMOUNT OF DATA THAT

916
00:33:20,560 --> 00:33:23,120
IS BEING COLLECTED, IF YOU WERE

917
00:33:23,120 --> 00:33:26,600
TO TAKE THE PREED SHEET AND MAKE

918
00:33:26,600 --> 00:33:29,120
LINEAR ACROSS EACH ROW, THAT ROW

919
00:33:29,120 --> 00:33:30,480
WOULD GO AROUND THE EARTH MORE

920
00:33:30,480 --> 00:33:31,520
THAN THREE TIMES.

921
00:33:31,520 --> 00:33:33,760
SO I AM GLAD WE ARE DIGITAL, IT

922
00:33:33,760 --> 00:33:35,320
IS VERY HELPFUL BUT IT IS A LOT

923
00:33:35,320 --> 00:33:37,920
OF DATA BEING CHECKED AND REALLY

924
00:33:37,920 --> 00:33:39,000
IMPRESSIVE WORK THAT THIS GROUP

925
00:33:39,000 --> 00:33:40,920
HAS DONE.

926
00:33:40,920 --> 00:33:44,920
WE HAVE DONE BIT MORE TO AUGMENT

927
00:33:44,920 --> 00:33:47,720
DATA AS YOU MIGHT IMAGINE,

928
00:33:47,720 --> 00:33:50,080
ELECTRONIC HEALTH RECORDS CAN BE

929
00:33:50,080 --> 00:33:51,480
MESSY AND INCOMPLETE SO WE WANT

930
00:33:51,480 --> 00:33:53,280
TO MAKE SURE WE ARE DOING OUR

931
00:33:53,280 --> 00:33:55,120
DUE DILIGENCE TO GET AS MUCH

932
00:33:55,120 --> 00:33:56,240
INFORMATION AS POSSIBLE.

933
00:33:56,240 --> 00:33:57,720
SO WE HAVE THE DATA HERE IS NOT

934
00:33:57,720 --> 00:34:00,320
REALLY THAT CRITICAL BUT IT IS

935
00:34:00,320 --> 00:34:02,160
NOW INCLUDING MORTALITY DATA, IT

936
00:34:02,160 --> 00:34:04,360
IS INCLUDING VIRAL VARIANT

937
00:34:04,360 --> 00:34:07,160
SEQUENCE DATA SO WE KNOW WHICH

938
00:34:07,160 --> 00:34:08,400
VARIANTS PARTICULAR PEOPLE HAVE

939
00:34:08,400 --> 00:34:10,760
BEEN EXPOSED TO AND HOW THAT

940
00:34:10,760 --> 00:34:11,560
MIGHT DRIVE OUTCOMES.

941
00:34:11,560 --> 00:34:14,640
WE ARE GETTING CMS DATA WHICH

942
00:34:14,640 --> 00:34:15,520
INCLUDES CLAIMS DATA,

943
00:34:15,520 --> 00:34:16,800
PRESCRIPTIONS AND OTHER

944
00:34:16,800 --> 00:34:17,520
INDICATORS OF HEALTHCARE

945
00:34:17,520 --> 00:34:19,600
UTILIZATION.

946
00:34:19,600 --> 00:34:22,600
SO THESE ADDED ON DATA SETS WILL

947
00:34:22,600 --> 00:34:26,040
BE MADE AVAILABLE LIKELY

948
00:34:26,040 --> 00:34:26,800
STARTING IN BEGINNING OF

949
00:34:26,800 --> 00:34:27,320
FEBRUARY.

950
00:34:27,320 --> 00:34:31,360
AND WE ARE NOT DONE THERE, WE

951
00:34:31,360 --> 00:34:32,720
WANT TO GO AND THINK ABOUT WHAT

952
00:34:32,720 --> 00:34:34,360
IS NEXT SO WORKING TOWARD

953
00:34:34,360 --> 00:34:37,120
FIGURING WAYS OF OBTAINING ICU

954
00:34:37,120 --> 00:34:38,280
WAGE INFORMATION FORM AS WELL AS

955
00:34:38,280 --> 00:34:38,760
IMAGING DATA.

956
00:34:38,760 --> 00:34:42,160
SO WE HAVE REALLY MOVED THE BAR

957
00:34:42,160 --> 00:34:44,920
IN ADOPTING PRIVACY TECHNIQUESES

958
00:34:44,920 --> 00:34:46,720
TO ENABLE THIS TYPE OF ACTIVITY

959
00:34:46,720 --> 00:34:49,080
AND MAXIMIZE POTENTIAL OF THESE

960
00:34:49,080 --> 00:34:50,520
EXTERNAL DATA SETS AS WELL AS

961
00:34:50,520 --> 00:34:52,560
OTHER FUNDED REPOSITORIES LIKE

962
00:34:52,560 --> 00:34:54,200
THOSE BEING DEALT FOR RECOVER

963
00:34:54,200 --> 00:34:59,080
PROGRAM THAT POST ACUTE SEQUELAE

964
00:34:59,080 --> 00:35:01,200
OF COVID CONDUCTED OUT OF NHLBI

965
00:35:01,200 --> 00:35:03,200
WE ARE PARTNERING WITH THEM SO A

966
00:35:03,200 --> 00:35:04,320
VARIETY OF THINGS PULLED INTO

967
00:35:04,320 --> 00:35:06,520
AND I THINK THE IS MAKING THIS

968
00:35:06,520 --> 00:35:12,920
DATA SYSTEM VERY ROBUST.

969
00:35:12,920 --> 00:35:14,240
I WILL GIVE YOU A SENSE OF

970
00:35:14,240 --> 00:35:15,720
ACTIVITIES ONGOING IN A MOMENT

971
00:35:15,720 --> 00:35:18,480
BUT I WANT TO RELAY TWO MORE

972
00:35:18,480 --> 00:35:22,920
POINTS THAT ARE NEW RELATED TO

973
00:35:22,920 --> 00:35:23,120
THAT.

974
00:35:23,120 --> 00:35:25,920
ONE IS WORKING TOWARDS A TRIBAL

975
00:35:25,920 --> 00:35:26,480
CONSULTATION, WE HAVE BEEN

976
00:35:26,480 --> 00:35:29,560
WORKING THIS OVER A YEAR BUT THE

977
00:35:29,560 --> 00:35:31,320
REASON THAT IT TOOK A BIT TO GET

978
00:35:31,320 --> 00:35:32,680
THERE, THERE'S OTHER ACTIVITIES

979
00:35:32,680 --> 00:35:34,920
AROUND COVID THAT ARE ALSO

980
00:35:34,920 --> 00:35:37,920
TRIBAL CONSULTATION SO WE HAVE

981
00:35:37,920 --> 00:35:39,360
BEEN IN THE QUEUE AND IT IS NOW

982
00:35:39,360 --> 00:35:39,760
OUR TURN.

983
00:35:39,760 --> 00:35:41,200
THE REASON THIS IS IMPORTANT,

984
00:35:41,200 --> 00:35:43,560
WHEN WE GET TO DEMOGRAPHIC FROM

985
00:35:43,560 --> 00:35:45,640
DATA CONTRIBUTORS IT CONTAINS

986
00:35:45,640 --> 00:35:49,520
THE OMB RACE TABLES WHICH

987
00:35:49,520 --> 00:35:50,760
INCLUDES AMERICAN INDIAN ALASKA

988
00:35:50,760 --> 00:35:53,520
NATIVE OR AIAN DATA.

989
00:35:53,520 --> 00:35:55,400
THESE ARE SELF-IDENTIFIED OR

990
00:35:55,400 --> 00:35:57,400
PROVIDER IDENTIFIED

991
00:35:57,400 --> 00:35:58,200
CLASSIFICATION OF RACE FROM

992
00:35:58,200 --> 00:36:00,320
EXISTING DATA.

993
00:36:00,320 --> 00:36:02,520
WE DON'T RECEIVE TRIBAL

994
00:36:02,520 --> 00:36:04,200
AFFILIATION DATA, SIMPLY THE

995
00:36:04,200 --> 00:36:05,200
RACE TABLES WE GET.

996
00:36:05,200 --> 00:36:06,760
KEEPING INTEGRITY OF THE TRIBAL

997
00:36:06,760 --> 00:36:08,360
SOVEREIGNTY AND PRIVACY WHILE WE

998
00:36:08,360 --> 00:36:10,760
ARE WAITING TRIBAL CONSULTATION

999
00:36:10,760 --> 00:36:12,920
WE HAVE BEEN MEETING WITH OUR

1000
00:36:12,920 --> 00:36:15,360
TRIBAL HEALTH RESEARCH OFFICE

1001
00:36:15,360 --> 00:36:17,120
AND CENTERS ACROSS THE COUNTRY

1002
00:36:17,120 --> 00:36:20,160
AND OTHER EXPERIENCED NIH POO TO

1003
00:36:20,160 --> 00:36:21,640
DISCUSS OPTIONS WHAT WE CAN DO

1004
00:36:21,640 --> 00:36:26,000
UNTIL WE HAVE THAT CONSULTATION.

1005
00:36:26,000 --> 00:36:27,120
BASED ON DIVISION CUSHIONS WITH

1006
00:36:27,120 --> 00:36:30,840
THE TRIBAL RESEARCH OFFICE,

1007
00:36:30,840 --> 00:36:31,760
NCATS DECIDED AT THAT TIME

1008
00:36:31,760 --> 00:36:33,320
OUTSET WHEN WE FIRST MADE THE

1009
00:36:33,320 --> 00:36:37,400
DATA PUBLICLY AVAILABLE WE

1010
00:36:37,400 --> 00:36:40,080
OBSCURED THE AIAN RACE DATA AS

1011
00:36:40,080 --> 00:36:43,640
WELL AS OBSCURED THE 2,659 ZIP

1012
00:36:43,640 --> 00:36:47,360
CODE DATA THAT OVERLAPS WITH

1013
00:36:47,360 --> 00:36:50,040
TRIBAL LANDS TO PREVENT

1014
00:36:50,040 --> 00:36:51,080
INFERENCE OF TRIBAL AFFILIATION.

1015
00:36:51,080 --> 00:36:52,560
THESE ARE TWO APPROACHES WE CAN

1016
00:36:52,560 --> 00:36:55,520
DO UNTIL WE HAVE TRIBAL

1017
00:36:55,520 --> 00:36:56,440
CONSULTATION.

1018
00:36:56,440 --> 00:36:57,920
WE LOOK FORWARD TO MEETING WITH

1019
00:36:57,920 --> 00:36:59,560
TRIBAL LEADERS AND HAVE AN

1020
00:36:59,560 --> 00:37:00,800
OPPORTUNITY TO PROVIDE WHETHER

1021
00:37:00,800 --> 00:37:05,680
AND HOW TO UTILIZE THESE SORTS

1022
00:37:05,680 --> 00:37:07,000
OF DATA AND (INAUDIBLE) WHICH

1023
00:37:07,000 --> 00:37:08,320
MIGHT BENEFIT THE COMMUNITY AS

1024
00:37:08,320 --> 00:37:08,720
WELL.

1025
00:37:08,720 --> 00:37:10,200
IN FEBRUARY WE WILL BE HAVING

1026
00:37:10,200 --> 00:37:11,880
THIS TRIBAL CONSULTATION AND

1027
00:37:11,880 --> 00:37:15,600
VARIETY OF ACTIVITIES WILL

1028
00:37:15,600 --> 00:37:16,120
FOLLOW SUIT.

1029
00:37:16,120 --> 00:37:18,320
THE SECOND AND LAST UPDATE IS

1030
00:37:18,320 --> 00:37:24,840
REALLY GIVE YOU A I WANT TO SHOW

1031
00:37:24,840 --> 00:37:25,920
AN OPPORTUNITY THAT CAME ACROSS

1032
00:37:25,920 --> 00:37:27,760
WITH US, THIS IS A REAL WORLD

1033
00:37:27,760 --> 00:37:30,320
EVIDENCE STUDY OUT OF UNIVERSITY

1034
00:37:30,320 --> 00:37:35,320
OF COLORADO BY THE INDIANS --

1035
00:37:35,320 --> 00:37:36,520
THEY ARE LOOKING AT

1036
00:37:36,520 --> 00:37:38,640
EFFECTIVENESS OF TREATMENT WITH

1037
00:37:38,640 --> 00:37:40,520
MONOCLONAL ANTIBODIES.

1038
00:37:40,520 --> 00:37:42,280
THERE IS AN OPPORTUNITY HERE TO

1039
00:37:42,280 --> 00:37:44,520
LOOK AT THE IMPACT OF VIRAL

1040
00:37:44,520 --> 00:37:47,160
VARIANTS SPECIFICALLY ON

1041
00:37:47,160 --> 00:37:47,920
MONOCLONAL ANTIBODY

1042
00:37:47,920 --> 00:37:48,960
INTERVENTION.

1043
00:37:48,960 --> 00:37:50,320
SO THIS IDEA CAME ACROSS BECAUSE

1044
00:37:50,320 --> 00:37:52,040
OF DISCUSSION WE HAD WITH JANET

1045
00:37:52,040 --> 00:38:00,640
WOOD COKE WHCOKC, ABOUTING
DEPUTY

1046
00:38:00,640 --> 00:38:02,400
COMMISSIONER OF THE FDA BUT ALSO

1047
00:38:02,400 --> 00:38:03,440
WHITE HOUSE LEADING A LOT OF

1048
00:38:03,440 --> 00:38:06,440
ACTIVITIES RELATED TO THE COVID

1049
00:38:06,440 --> 00:38:06,960
RESPONSE.

1050
00:38:06,960 --> 00:38:08,800
SO THIS CAME OUT OF JANET'S HEAD

1051
00:38:08,800 --> 00:38:11,040
AND WE WANTED TO SEE THIS KIND

1052
00:38:11,040 --> 00:38:14,160
OF STUDY HAPPEN.

1053
00:38:14,160 --> 00:38:17,480
AND BECAUSE OF THE OPPORTUNITIES

1054
00:38:17,480 --> 00:38:20,840
WE HAVE WITHIN NCATS THERE WAS A

1055
00:38:20,840 --> 00:38:21,480
WAY TO GET GET COVID SPECIFIC

1056
00:38:21,480 --> 00:38:22,240
FUNDS TO SUPPORT THIS KIND OF

1057
00:38:22,240 --> 00:38:25,120
ACTIVITY.

1058
00:38:25,120 --> 00:38:27,920
NOW BEHOLD THIS PROJECT IS

1059
00:38:27,920 --> 00:38:30,200
ESSENTIALLY TO ENROLL 4,000

1060
00:38:30,200 --> 00:38:34,520
INDIVIDUALS SOME WHO RECEIVED

1061
00:38:34,520 --> 00:38:35,720
MONOCLONAL ANTIBODIES AND SOME

1062
00:38:35,720 --> 00:38:36,760
WHO DIDN'T AND FOLLOW THE

1063
00:38:36,760 --> 00:38:37,560
INDIVIDUALS WITH TELEPHONE

1064
00:38:37,560 --> 00:38:39,760
SURVEYS AND LIKE, WE ALSO

1065
00:38:39,760 --> 00:38:41,920
RECEIVE ELECTRONIC HEALTH RECORD

1066
00:38:41,920 --> 00:38:42,520
INFORMATION TOO.

1067
00:38:42,520 --> 00:38:44,440
AND THIS IS A WAY FOR US TO

1068
00:38:44,440 --> 00:38:45,680
DETERMINE THE EFFECTIVENESS OF

1069
00:38:45,680 --> 00:38:47,680
THE TREATMENT AND PREVENTING

1070
00:38:47,680 --> 00:38:49,520
HOSPITALIZATION AND ATTRACT --

1071
00:38:49,520 --> 00:38:50,760
TO TRACK THOSE LONGER TERM

1072
00:38:50,760 --> 00:38:53,760
SYMPTOMS AS WELL.

1073
00:38:53,760 --> 00:38:55,760
SO THE UNIVERSITY OF COLORADO

1074
00:38:55,760 --> 00:38:57,120
TEAM RECOGNIZED THAT WE REALLY

1075
00:38:57,120 --> 00:38:58,920
NEEDED TO UNDERSTAND WHO IS MORE

1076
00:38:58,920 --> 00:39:01,240
AT RISK TO GET THE DISEASE AND

1077
00:39:01,240 --> 00:39:04,480
MORE AT RISK TO BE HOSPITALIZED

1078
00:39:04,480 --> 00:39:06,000
SO THAT THE LIMITED SUPPLY

1079
00:39:06,000 --> 00:39:07,680
PERHAPS SOMETIMES OF THESE

1080
00:39:07,680 --> 00:39:08,920
MONOCLONAL ANTIBODIES COULD BE

1081
00:39:08,920 --> 00:39:11,000
USED AND DIRECTED EFFICIENTLY

1082
00:39:11,000 --> 00:39:12,320
AND MOST EQUITABLY.

1083
00:39:12,320 --> 00:39:13,720
SO THESE ARE THE DATA THAT I'M

1084
00:39:13,720 --> 00:39:15,840
SHOWING HERE ON THE SCREEN, IT

1085
00:39:15,840 --> 00:39:18,240
IS THIS IS OUT OF NET ARCHIVE,

1086
00:39:18,240 --> 00:39:20,520
NOT PUBLISHED YET BUT IT IS

1087
00:39:20,520 --> 00:39:22,120
PRE-PRINT SERVER ON MED

1088
00:39:22,120 --> 00:39:22,720
ARCHIVES.

1089
00:39:22,720 --> 00:39:25,320
SO STILL ONGOING BUT EARLIER

1090
00:39:25,320 --> 00:39:27,520
RESULTS THESE ARE DATA THROUGH

1091
00:39:27,520 --> 00:39:30,120
JULY SHOW IMPRESSIVE RESULTS BY

1092
00:39:30,120 --> 00:39:32,000
DAY 28 FOR EXAMPLE, THIS FIRST

1093
00:39:32,000 --> 00:39:34,520
RED LINE HERE, THE MONOCLONAL

1094
00:39:34,520 --> 00:39:37,760
ANTIBODY SHOW 50% EFFECTIVENESS

1095
00:39:37,760 --> 00:39:39,520
PREVENTING HOSPITALIZATION AND

1096
00:39:39,520 --> 00:39:41,240
THEN DOWN AT BOTTOM YOU SEE IT

1097
00:39:41,240 --> 00:39:42,760
IS QUITE EFFECTIVE IN TERMS OF

1098
00:39:42,760 --> 00:39:46,200
THE LENGTH OF STAY AND

1099
00:39:46,200 --> 00:39:47,080
MINIMIZING LENGTH OF STAY OF

1100
00:39:47,080 --> 00:39:48,640
THOSE WHO ARE HOSPITALIZED.

1101
00:39:48,640 --> 00:39:53,280
THEN THERE'S ALSO BY DAY 90 IN

1102
00:39:53,280 --> 00:39:55,720
TERMS OF ALL CAUSE MORTALITY,

1103
00:39:55,720 --> 00:39:56,960
THERE'S 83% EFFECTIVENESS IN

1104
00:39:56,960 --> 00:39:57,760
PREVENTING DEATH.

1105
00:39:57,760 --> 00:39:59,200
SO THESE ARE REALLY IMPORTANT

1106
00:39:59,200 --> 00:40:01,200
DATA FOR US TO UNDERSTAND AND

1107
00:40:01,200 --> 00:40:04,520
KNOW AND FIGURE HOW TO BEST USE

1108
00:40:04,520 --> 00:40:05,680
THESE KINDS OF TREATMENTS IF

1109
00:40:05,680 --> 00:40:08,000
THEY ARE IN LIMITED SUPPLY.

1110
00:40:08,000 --> 00:40:09,680
SO WE LOOK FORWARD TO I HOPE

1111
00:40:09,680 --> 00:40:11,120
BEING ABLE TO EXPAND SOME OF

1112
00:40:11,120 --> 00:40:15,120
THIS WORK, AND ESPECIALLY AS THE

1113
00:40:15,120 --> 00:40:16,560
PANDEMIC CONTINUES, THIS KIND OF

1114
00:40:16,560 --> 00:40:21,040
INFORMATION IS VERY VALUABLE.

1115
00:40:21,040 --> 00:40:23,280
THIS IS A LOT MORE WORK COMING

1116
00:40:23,280 --> 00:40:25,480
OUT OF N 3C, HIGHLIGHT A FEW

1117
00:40:25,480 --> 00:40:26,920
PAPERS HERE IN TERMS OF

1118
00:40:26,920 --> 00:40:29,280
PUBLICATION AS WELL AS PRE-PRINT

1119
00:40:29,280 --> 00:40:30,760
AND SOME OF THE NEWS OUTLETS

1120
00:40:30,760 --> 00:40:32,120
CAPTURING A LOT OF THE WORK

1121
00:40:32,120 --> 00:40:35,160
GOING ON IN NTC SO THAT'S

1122
00:40:35,160 --> 00:40:38,120
EXCITING TO SEE THIS UPTAKE OF

1123
00:40:38,120 --> 00:40:39,720
THIS PARTICULAR DATA SET, IT IS

1124
00:40:39,720 --> 00:40:41,480
QUITE RICH AND IT IS GETTING

1125
00:40:41,480 --> 00:40:42,720
RICHER WITH THAT INFORMATION I

1126
00:40:42,720 --> 00:40:44,720
KNOW IT WILL BE VALUABLE.

1127
00:40:44,720 --> 00:40:48,000
WITH THAT ADDED INFORMATION.

1128
00:40:48,000 --> 00:40:49,320
IT IS HARD SOMETIMES GET

1129
00:40:49,320 --> 00:40:51,240
MAGNITUDE ASIDE FROM THE FACT

1130
00:40:51,240 --> 00:40:53,320
THE DATA GO AROUND EARTH THREE

1131
00:40:53,320 --> 00:40:54,440
TIMES.

1132
00:40:54,440 --> 00:40:56,440
LILY PORTILLA SENT ME NUMBERS OF

1133
00:40:56,440 --> 00:40:58,120
AGREEMENTS IN SUPPORT OF N 3C

1134
00:40:58,120 --> 00:41:00,440
THAT WE OBTAIN TO DATE, IT IS

1135
00:41:00,440 --> 00:41:01,760
AMAZING, THIS IS TRULY AN

1136
00:41:01,760 --> 00:41:03,920
ENTERPRISE LEVEL COLLABORATION

1137
00:41:03,920 --> 00:41:06,040
WITH OVER 400 PAYMENTS IN PLACE

1138
00:41:06,040 --> 00:41:07,840
THAT SUPPORT THIS WORK.

1139
00:41:07,840 --> 00:41:09,280
SO I JUST GIVE YOU A SENSE OF

1140
00:41:09,280 --> 00:41:11,360
THE MAGNITUDE OF THAT.

1141
00:41:11,360 --> 00:41:14,280
SO I'M GOING TO SWITCH GEARS A

1142
00:41:14,280 --> 00:41:15,960
LITTLE BIT NOW, I WANT TO CLOSE

1143
00:41:15,960 --> 00:41:17,520
OUT BY TALKING ABOUT WHAT IS

1144
00:41:17,520 --> 00:41:20,520
NEXT FOR NCATS.

1145
00:41:20,520 --> 00:41:22,720
ON DECEMBER 7 AS YOU MAY HAVE

1146
00:41:22,720 --> 00:41:24,880
REMEMBERED IT IS OUR BIRTHDAY,

1147
00:41:24,880 --> 00:41:27,640
AND WE HAD OUR BIRTHDAY PARTY

1148
00:41:27,640 --> 00:41:30,680
AND IT WAS JUST REALLY A

1149
00:41:30,680 --> 00:41:31,600
WONDERFUL EVENT.

1150
00:41:31,600 --> 00:41:34,800
WE HAD OUR 10TH ANNIVERSARY

1151
00:41:34,800 --> 00:41:36,600
CELEBRATION WHICH WHERE WE HAD

1152
00:41:36,600 --> 00:41:41,520
771 ATTENDEES AND AVAILABLE ON

1153
00:41:41,520 --> 00:41:42,880
DEMAND, YOU ARE WELCOME TO VIEW

1154
00:41:42,880 --> 00:41:45,120
ON DEMAND AS WELL.

1155
00:41:45,120 --> 00:41:47,040
BUT IT GAVE US AN OPPORTUNITY TO

1156
00:41:47,040 --> 00:41:48,960
TAKE STOCK AND TALK ABOUT MANY

1157
00:41:48,960 --> 00:41:50,560
OF THE PROGRAMS AND TOPICS THAT

1158
00:41:50,560 --> 00:41:52,440
ARE LISTED HERE FROM PATIENT

1159
00:41:52,440 --> 00:41:56,360
IMPACT TO DATA DRIVEN SOLUTIONS.

1160
00:41:56,360 --> 00:41:57,280
IN ADDITION O THE COVID WORK WE

1161
00:41:57,280 --> 00:42:02,480
HAVE BEEN DOING.

1162
00:42:02,480 --> 00:42:07,200
WE TALKED TO SUMMARIZE IF YOU

1163
00:42:07,200 --> 00:42:08,880
WILL, WE TALK ABOUT HOW

1164
00:42:08,880 --> 00:42:10,320
TRANSITIONAL SCIENCE IS REALLY

1165
00:42:10,320 --> 00:42:13,000
PROVEN ITSELF OVER AND OVER TO

1166
00:42:13,000 --> 00:42:15,560
DRIVE INNOVATION AND LEAD

1167
00:42:15,560 --> 00:42:16,560
TRANSFORMATIONAL APPROACHES THAT

1168
00:42:16,560 --> 00:42:18,160
BRING US TO OUR ABILITY TO DO

1169
00:42:18,160 --> 00:42:20,800
MORE PREDICTIVE PRE-CLINICAL

1170
00:42:20,800 --> 00:42:22,560
PIPELINE DEVELOPMENT, TO EXPAND

1171
00:42:22,560 --> 00:42:27,960
OUR REPERTOIRE IN TECHNOLOGIES,

1172
00:42:27,960 --> 00:42:29,960
TO REVOLUTIONIZE DIAGNOSTIC

1173
00:42:29,960 --> 00:42:32,440
TREATMENTS TO PRIORITIZE DEI AND

1174
00:42:32,440 --> 00:42:33,600
ALL THE ACTIVITIES THAT WE

1175
00:42:33,600 --> 00:42:33,960
SUPPORT.

1176
00:42:33,960 --> 00:42:35,440
IN WAYS THAT WE TRAIN THE NEXT

1177
00:42:35,440 --> 00:42:40,320
GENERATION OF SCIENTISTS AND

1178
00:42:40,320 --> 00:42:42,400
ENGAGE OLD STAKEHOLDERS,

1179
00:42:42,400 --> 00:42:44,160
SHOULDN'T SAY OLD BUT PERHAPS

1180
00:42:44,160 --> 00:42:45,680
WHO HAVE BEEN OUR STAKEHOLDERS A

1181
00:42:45,680 --> 00:42:47,000
FILE AND FINDING NEW ONES WE

1182
00:42:47,000 --> 00:42:51,520
WANT TO BUILD THAT TRUST IN AND

1183
00:42:51,520 --> 00:42:52,120
NOSHTURE RELATIONSHIPS GOING

1184
00:42:52,120 --> 00:42:52,360
FORWARD.

1185
00:42:52,360 --> 00:42:53,720
THIS IS THE WAY TO BRING YOUR

1186
00:42:53,720 --> 00:42:55,040
TREATMENTS TO ALL PEOPLE MORE

1187
00:42:55,040 --> 00:42:57,360
QUICKLY.

1188
00:42:57,360 --> 00:42:59,360
THIS IS NOT JUST OUR MANTRA.

1189
00:42:59,360 --> 00:43:01,840
THIS IS OUR VISION.

1190
00:43:01,840 --> 00:43:03,960
WITH THAT VISION IT PROVIDED AN

1191
00:43:03,960 --> 00:43:05,240
OPPORTUNITY TO LOOK AHEAD O THE

1192
00:43:05,240 --> 00:43:07,480
NEXT DECADE, IN THE KEY NODE

1193
00:43:07,480 --> 00:43:13,120
ADDRESS DURING THAT EVENT I SET

1194
00:43:13,120 --> 00:43:15,400
FORTH THREE AUDACIOUS GOALS THAT

1195
00:43:15,400 --> 00:43:16,000
ARE FORWARD-LOOKING AND I WANT

1196
00:43:16,000 --> 00:43:18,120
TO SET A PATH NEXT DECADE HOW TO

1197
00:43:18,120 --> 00:43:19,240
OBTAIN THEM.

1198
00:43:19,240 --> 00:43:20,520
NCATS COUNCIL HEAR YOUR THOUGHTS

1199
00:43:20,520 --> 00:43:22,120
AND REACTS AND AS WE GET A

1200
00:43:22,120 --> 00:43:24,200
PERMANENT DIRECTOR, FOR NCATS

1201
00:43:24,200 --> 00:43:25,920
THERE WILL BE AN OPPORTUNITY TO

1202
00:43:25,920 --> 00:43:29,400
HONE AND DEVELOP AND METRACISE

1203
00:43:29,400 --> 00:43:29,760
THESE MORE.

1204
00:43:29,760 --> 00:43:32,480
BUT I WANT TO RUN LIEU THEM

1205
00:43:32,480 --> 00:43:33,560
BECAUSE ED I WOULD LIKE YOUR

1206
00:43:33,560 --> 00:43:34,800
REACTIONS SO GOAL NUMBER ONE,

1207
00:43:34,800 --> 00:43:36,320
MORE TREATMENT.

1208
00:43:36,320 --> 00:43:38,320
PERIOD.

1209
00:43:38,320 --> 00:43:41,680
RIGHT NOW WE HAVE 5% DISEASE

1210
00:43:41,680 --> 00:43:43,520
THAT HAVE A TREATMENT SHOWN HERE

1211
00:43:43,520 --> 00:43:47,840
IN THAT -- THIS BOTTOM BAR HERE

1212
00:43:47,840 --> 00:43:49,280
ON THE GRAPHIC WITH -- WE HAVE

1213
00:43:49,280 --> 00:43:51,400
ABOUT -- WE KNOW THERE'S OVER

1214
00:43:51,400 --> 00:43:54,280
7,000 RARE DISEASE TO DATE BUT

1215
00:43:54,280 --> 00:43:56,360
MORE ARE ON THE WAY.

1216
00:43:56,360 --> 00:43:58,920
WE ONLY HAVE 500 THERAPIES SO 5%

1217
00:43:58,920 --> 00:44:00,200
OF DISEASE HAVE A TREATMENT.

1218
00:44:00,200 --> 00:44:02,200
LET'S WORK TO GET THAT NUMBER UP

1219
00:44:02,200 --> 00:44:04,040
SO THAT A QUARTER OF KNOWN

1220
00:44:04,040 --> 00:44:06,120
DISEASE HAVE A TREATMENT IN THE

1221
00:44:06,120 --> 00:44:09,080
PIPELINE SO WE WENT 5% TO 25%.

1222
00:44:09,080 --> 00:44:11,760
WE ALSO KNOW 90% OF DRUGS IN

1223
00:44:11,760 --> 00:44:12,640
CLINICAL TRIALS PAIL BECAUSE OF

1224
00:44:12,640 --> 00:44:15,960
THE LACK OF EFFICACY AND SAFETY

1225
00:44:15,960 --> 00:44:16,520
CONCERNS.

1226
00:44:16,520 --> 00:44:19,040
IN VITRO ASSAYS THAT

1227
00:44:19,040 --> 00:44:20,240
RECAPITULATE HUMAN PHYSIOLOGY

1228
00:44:20,240 --> 00:44:21,600
AND PATHOLOGY SHOW INCREDIBLE

1229
00:44:21,600 --> 00:44:24,200
PROMISE BEING MORE PREDICTIVE OF

1230
00:44:24,200 --> 00:44:25,720
TOXICITY AND EFFICACY IN HUMANS

1231
00:44:25,720 --> 00:44:27,520
SO WE NEED TO REALLY ENABLE THAT

1232
00:44:27,520 --> 00:44:29,120
KIND OF DEVELOPMENT AND THOSE

1233
00:44:29,120 --> 00:44:31,040
TYPES OF TECHNOLOGIES TO HAVE A

1234
00:44:31,040 --> 00:44:34,640
WIDE ARRAY OF RESOURCES THAT

1235
00:44:34,640 --> 00:44:37,720
DON'T JUST MODEL TISSUES AND

1236
00:44:37,720 --> 00:44:39,120
ORGANS BUT MODEL DIVERSITY OF

1237
00:44:39,120 --> 00:44:40,520
INDIVIDUAL, MODEL GENETIC MAKE

1238
00:44:40,520 --> 00:44:41,880
UP, ENVIRONMENTAL EXPOSURES.

1239
00:44:41,880 --> 00:44:43,160
SO THERE'S MORE WORK TORR DO

1240
00:44:43,160 --> 00:44:44,320
HERE.

1241
00:44:44,320 --> 00:44:45,680
-- WORK TO DO HERE.

1242
00:44:45,680 --> 00:44:47,720
THERE'S OTHER INITIATIVES AS

1243
00:44:47,720 --> 00:44:50,320
WELL THAT WILL DEMOCRATIZE AND

1244
00:44:50,320 --> 00:44:51,480
DISSEMINATE NEW TREATMENT

1245
00:44:51,480 --> 00:44:55,120
APPROACHES, WE TALK ABOUT THE

1246
00:44:55,120 --> 00:44:57,960
PAGT PROGRAM AND THERAPY

1247
00:44:57,960 --> 00:44:58,360
CONSORTIUM.

1248
00:44:58,360 --> 00:45:00,920
THE SOMATIC CELL GENE EDITING

1249
00:45:00,920 --> 00:45:02,080
INITIATIVE; THESE ARE POISED TO

1250
00:45:02,080 --> 00:45:03,920
TRANSPERFORM THE PIPELINE FOR

1251
00:45:03,920 --> 00:45:06,320
GENE TARGETED THERAPIES BY

1252
00:45:06,320 --> 00:45:08,240
BREAKING DOWN THE BARRIERS OF

1253
00:45:08,240 --> 00:45:09,600
THE PRE-CLINICAL TO CLINICAL

1254
00:45:09,600 --> 00:45:11,320
APPROACHES BUT ALSO ADDRESS THE

1255
00:45:11,320 --> 00:45:13,520
MANUFACTURING AND THE REGULATORY

1256
00:45:13,520 --> 00:45:16,040
HURDLES IN THE PIPELINE AND SO

1257
00:45:16,040 --> 00:45:17,600
ANY RARE DISEASE CAUSE BY SINGLE

1258
00:45:17,600 --> 00:45:19,880
GENETIC MUTATION WE HOPE WILL BE

1259
00:45:19,880 --> 00:45:22,320
ABLE TO HAVE THE OPPORTUNITY TO

1260
00:45:22,320 --> 00:45:24,040
GET FIXED BY SOME OF THESE.

1261
00:45:24,040 --> 00:45:26,120
AND WHEN YOU THINK ABOUT 80% OF

1262
00:45:26,120 --> 00:45:27,800
THE RARE DISEASE ARE CAUSED BY

1263
00:45:27,800 --> 00:45:30,120
SINGLE GENE DISORDERS, THAT

1264
00:45:30,120 --> 00:45:33,240
MAKES IT SO THAT IF THIS ONLY

1265
00:45:33,240 --> 00:45:37,280
WORKS FOR HALF, THAT'S HUNDREDS

1266
00:45:37,280 --> 00:45:38,120
OF DISEASES.

1267
00:45:38,120 --> 00:45:40,200
THESE ARE WHY THE TYPES OF

1268
00:45:40,200 --> 00:45:42,520
PROGRAMS WHAT WE DO AT N CATS

1269
00:45:42,520 --> 00:45:44,440
WITH SRI AND ACADEMIA AND

1270
00:45:44,440 --> 00:45:46,120
PATIENTS, PATIENT ADVOCACY

1271
00:45:46,120 --> 00:45:47,560
GROUPS AND REGULATORS AND

1272
00:45:47,560 --> 00:45:49,680
FEDERAL PARTNERS WHO COME TO

1273
00:45:49,680 --> 00:45:51,800
IDENTIFY AND DIAGNOSE WHAT IS

1274
00:45:51,800 --> 00:45:52,800
CAUSING THIS SLOW PACE OF

1275
00:45:52,800 --> 00:45:54,120
TREATMENT AND DEVELOPMENT OF THE

1276
00:45:54,120 --> 00:45:55,800
TREATMENT AND WE ARE WORKING

1277
00:45:55,800 --> 00:45:57,280
HARD AND COLLABORATIVELY TO

1278
00:45:57,280 --> 00:45:59,280
BUILD PROGRAMS THAT WILL BRING

1279
00:45:59,280 --> 00:46:01,360
ABOUT THIS REVOLUTIONARY

1280
00:46:01,360 --> 00:46:02,200
TRANSFORMATION SO THIS IS A

1281
00:46:02,200 --> 00:46:09,320
MODEL THAT WE LOOK FORWARD TO.

1282
00:46:09,320 --> 00:46:11,040
GOAL TWO ALL PEOPLE.

1283
00:46:11,040 --> 00:46:13,160
WE WANT TO DRAMATICALLY INCREASE

1284
00:46:13,160 --> 00:46:15,360
INCLUSIVITY IN ALL AREAS, WORK

1285
00:46:15,360 --> 00:46:16,760
FORCE TRAINING RESEARCH CLINICAL

1286
00:46:16,760 --> 00:46:18,520
TRIALS AND HEALTH OUTCOMES.

1287
00:46:18,520 --> 00:46:22,440
AND JUST WHEN YOU THINK ABOUT

1288
00:46:22,440 --> 00:46:25,240
COVID, VERY RECENT AND STARK

1289
00:46:25,240 --> 00:46:27,240
EXAMPLES, ARE COMING OUT FROM

1290
00:46:27,240 --> 00:46:31,640
COVID FOR SURE, BUT THE COVID-19

1291
00:46:31,640 --> 00:46:33,720
OCCURRENCE OF DEATH AMONG RACIAL

1292
00:46:33,720 --> 00:46:36,720
ETHNIC POPULATIONS IN RURAL

1293
00:46:36,720 --> 00:46:38,040
COMMUNITIES IN OUR COUNTRY HAVE

1294
00:46:38,040 --> 00:46:39,840
BEEN ONE OF THE MOST PAINFUL

1295
00:46:39,840 --> 00:46:40,640
ACTS TO SEE DURING THIS

1296
00:46:40,640 --> 00:46:41,120
PANDEMIC.

1297
00:46:41,120 --> 00:46:43,920
BLACK AND AFRICAN AMERICANS

1298
00:46:43,920 --> 00:46:46,520
HISPANIC AND LATINO, AMERICAN

1299
00:46:46,520 --> 00:46:48,120
INDIAN AND ALASKA NATIVE ARE

1300
00:46:48,120 --> 00:46:51,000
CONTRACTING AND DYING FROM

1301
00:46:51,000 --> 00:46:52,480
COVID-19 THAN WHITE ASIAN

1302
00:46:52,480 --> 00:46:53,160
COUNTER PARTS IN THOSE

1303
00:46:53,160 --> 00:46:53,600
POPULATIONS.

1304
00:46:53,600 --> 00:46:56,720
THERE WAS A RECENT PRE-PRINT OUT

1305
00:46:56,720 --> 00:47:01,040
OF THE NIGMS CTR PROGRAM USING M

1306
00:47:01,040 --> 00:47:03,320
3C SHOWING RATES IN RURAL

1307
00:47:03,320 --> 00:47:05,200
COMMUNITIES ARE 40% HIGHER THAN

1308
00:47:05,200 --> 00:47:06,280
IN OTHER COMMUNITIES.

1309
00:47:06,280 --> 00:47:07,880
THIS IS A BIG DEAL.

1310
00:47:07,880 --> 00:47:10,040
WE NEED TO ADDRESS IT, WE NEED

1311
00:47:10,040 --> 00:47:13,680
TO DO BETTER.

1312
00:47:13,680 --> 00:47:16,520
CTSA ACROSS THE COUNTRY

1313
00:47:16,520 --> 00:47:18,280
PRIORITIZED ENGAGEMENT

1314
00:47:18,280 --> 00:47:19,120
PARTNERSHIPS AND INNOVATING

1315
00:47:19,120 --> 00:47:20,040
AROUND STRATEGIES THAT MEET

1316
00:47:20,040 --> 00:47:23,040
PEOPLE WHERE THEY ARE, MOBILE

1317
00:47:23,040 --> 00:47:25,480
VANS, COMMUNITY, CENTERS PLACES

1318
00:47:25,480 --> 00:47:27,200
OF WORSHIP, GROCERY STORES

1319
00:47:27,200 --> 00:47:28,680
LIBRARIES, ALL THOSE SORTS OF

1320
00:47:28,680 --> 00:47:29,040
THINGS.

1321
00:47:29,040 --> 00:47:32,480
THESE EFFORTS ARE MADE CTSA

1322
00:47:32,480 --> 00:47:33,280
CORNERSTONE OF THE TRUSTED

1323
00:47:33,280 --> 00:47:35,840
COMMUNITY PARTNERS THAT HAVE AND

1324
00:47:35,840 --> 00:47:37,520
WE NEED TO ENABLE THEM MORE TO

1325
00:47:37,520 --> 00:47:39,520
PIVOT RAPIDLY ON A VARIETY OF

1326
00:47:39,520 --> 00:47:40,720
HEALTH OUTCOMES WE ARE

1327
00:47:40,720 --> 00:47:44,360
INTERESTED IN PURSUING AS WELL.

1328
00:47:44,360 --> 00:47:46,360
TALK ABOUT DEIA EFFORTS A BIT

1329
00:47:46,360 --> 00:47:48,040
AGO AND THE POINT IS THAT

1330
00:47:48,040 --> 00:47:49,320
STUDIES OF TOMORROW, WHAT WE DO

1331
00:47:49,320 --> 00:47:52,440
IN THE NEXT DECADE ENSURE NO ONE

1332
00:47:52,440 --> 00:47:54,600
IS LEFT BEHIND IN OUR PLANNING

1333
00:47:54,600 --> 00:47:56,520
DESIGNING OUR IMPLEMENTING.

1334
00:47:56,520 --> 00:48:00,120
RESEARCH IMPROVES LIVES FOR ALL.

1335
00:48:00,120 --> 00:48:02,000
INCREASING DIVERSITY IN ALL WAYS

1336
00:48:02,000 --> 00:48:04,240
IS GOAL NUMBER TWO.

1337
00:48:04,240 --> 00:48:07,360
GOAL 3, MORE QUICKLY, WE WANT TO

1338
00:48:07,360 --> 00:48:09,920
REDUCE THE TIME IT TAKES FOR A

1339
00:48:09,920 --> 00:48:11,200
TREATMENT TO REACH THE MARKET BY

1340
00:48:11,200 --> 00:48:12,760
HALF.

1341
00:48:12,760 --> 00:48:15,360
IT TAKES 10 TO 15 YEARS AND

1342
00:48:15,360 --> 00:48:16,360
$2.6 BILLION FOR DRUG TO MAKE IT

1343
00:48:16,360 --> 00:48:19,480
TO MARKET.

1344
00:48:19,480 --> 00:48:20,720
WHICH NEED REDUCE THAT TIME.

1345
00:48:20,720 --> 00:48:23,160
TO DO THAT WE NEED TO FAIL FAST,

1346
00:48:23,160 --> 00:48:25,760
EARLIER AND IMPORTANTLY WE NEED

1347
00:48:25,760 --> 00:48:27,440
TO FAIL FORWARD AND THAT IS A

1348
00:48:27,440 --> 00:48:29,560
KEY FACTOR BECAUSE WHEN YOU FAIL

1349
00:48:29,560 --> 00:48:30,800
FORWARD YOU ARE TRIPPING OVER

1350
00:48:30,800 --> 00:48:32,480
THE VULNERABILITIES THAT WE HAVE

1351
00:48:32,480 --> 00:48:35,120
FOUND AND YOU CAN FIX THEM BUT

1352
00:48:35,120 --> 00:48:40,720
YOU -- WHEN YOU FAIL FORWARD,

1353
00:48:40,720 --> 00:48:41,920
YOU NOT HOLDING YOURSELF BACK

1354
00:48:41,920 --> 00:48:43,120
YOU ARE FAILING FORWARD TO MAKE

1355
00:48:43,120 --> 00:48:46,040
SURE YOU IDENTIFY THOSE

1356
00:48:46,040 --> 00:48:47,400
VULNERABILITIES AND MITIGATE

1357
00:48:47,400 --> 00:48:49,000
THAT RISK.

1358
00:48:49,000 --> 00:48:50,520
IT IS IMPORTANT TO DO THAT.

1359
00:48:50,520 --> 00:48:53,200
WE WANT TO PROMOTE EMPLOY MORE

1360
00:48:53,200 --> 00:48:54,600
STRATEGIES ADDRESSING MANY

1361
00:48:54,600 --> 00:48:55,960
DISEASES AT A TIME AND FINDING

1362
00:48:55,960 --> 00:48:57,320
WHAT IS COMMON ACROSS DISEASE

1363
00:48:57,320 --> 00:48:59,840
AND TARGETING THOSE UNDERLYING

1364
00:48:59,840 --> 00:49:00,520
MECHANISMS.

1365
00:49:00,520 --> 00:49:01,600
ON TOP OF THAT HAVE TRAINING THE

1366
00:49:01,600 --> 00:49:05,680
NEXT GENERATION OF SCIENTISTS IS

1367
00:49:05,680 --> 00:49:07,440
HUGELY IMPORTANT TO HELP RETHINK

1368
00:49:07,440 --> 00:49:11,200
HOW WE TRAIN OUR SCIENTISTS AND

1369
00:49:11,200 --> 00:49:12,480
ENCOURAGING TO THINK MORE

1370
00:49:12,480 --> 00:49:13,600
REVOLUTIONARY AND

1371
00:49:13,600 --> 00:49:14,320
TRANSFORMATIONAL TERMS AS

1372
00:49:14,320 --> 00:49:15,960
OPPOSED TO MORE EVOLUTIONARY

1373
00:49:15,960 --> 00:49:18,000
TERMS.

1374
00:49:18,000 --> 00:49:20,040
FINDING COLLABORATION AND PART

1375
00:49:20,040 --> 00:49:22,600
SHIPS ARE CRITICAL FOR NCATS AND

1376
00:49:22,600 --> 00:49:24,040
WHAT WE DO AND WHEN WE THINK

1377
00:49:24,040 --> 00:49:25,920
ABOUT EXECUTING AGREEMENTS THOSE

1378
00:49:25,920 --> 00:49:27,520
CAN TAKE TIME SO WHAT WE HAVE

1379
00:49:27,520 --> 00:49:30,320
BEEN ABLE TO DO IS QUICKLY

1380
00:49:30,320 --> 00:49:31,840
LAUNCH COLLABORATION BECAUSE WE

1381
00:49:31,840 --> 00:49:36,520
USE COLLABORATIVE THEM PLACE OR

1382
00:49:36,520 --> 00:49:37,640
AGREEMENT THEM PLACE THAT ALLOW

1383
00:49:37,640 --> 00:49:39,320
COLLABORATIONS TO HAPPEN ON

1384
00:49:39,320 --> 00:49:41,560
ORDER OF HOURS, DAYS SOMETIMES

1385
00:49:41,560 --> 00:49:44,040
BUT THERE'S BEEN A COUPLE OF

1386
00:49:44,040 --> 00:49:45,800
THEM DONE ON HOURS AND NOT

1387
00:49:45,800 --> 00:49:46,200
MONTHS.

1388
00:49:46,200 --> 00:49:47,880
SO THIS TIME SAVING IS HUGELY

1389
00:49:47,880 --> 00:49:49,960
IMPORTANT FOR US.

1390
00:49:49,960 --> 00:49:51,480
THE COVID SCENARIO FOR THE

1391
00:49:51,480 --> 00:49:53,120
CLINICAL TRIALS HAVE REALLY

1392
00:49:53,120 --> 00:49:55,600
IDENTIFIED HOW MASTERED UMBRELLA

1393
00:49:55,600 --> 00:49:59,200
PROTOCOLS ARE REALLY HELPING US

1394
00:49:59,200 --> 00:50:01,560
TO BE CLINICAL TRIAL READY.

1395
00:50:01,560 --> 00:50:04,000
THINKING SINGLE IRB REVIEW

1396
00:50:04,000 --> 00:50:05,240
BOARDS AND ALLOWING THEM TO

1397
00:50:05,240 --> 00:50:07,120
ACTIVATE MORE EFFICIENTLY AND

1398
00:50:07,120 --> 00:50:08,080
ENROLL PARTICIPANTS SOONER,

1399
00:50:08,080 --> 00:50:10,400
THESE ARE THE KEY ACTIVITIES.

1400
00:50:10,400 --> 00:50:12,840
AT THE LAST COUNCIL I TALK DATA

1401
00:50:12,840 --> 00:50:15,320
SCIENCE EFFORTS AND NEW TOOLS TO

1402
00:50:15,320 --> 00:50:17,120
SEE PATTERNS OF BIG DATA THAT WE

1403
00:50:17,120 --> 00:50:21,160
HAVEN'T SEEN BEFORE.

1404
00:50:21,160 --> 00:50:26,360
OF COURSE N 3C SHOWS US WE CAN

1405
00:50:26,360 --> 00:50:27,800
CATALYZE THE HEALTH DATA AS A

1406
00:50:27,800 --> 00:50:29,720
PRINCIPLE THAT IS SOMETHING TO

1407
00:50:29,720 --> 00:50:32,720
PUSH FOR ALL DISEASES.

1408
00:50:32,720 --> 00:50:34,120
THINKING OTHER APPROACHES LIKE

1409
00:50:34,120 --> 00:50:36,120
DRUG REPURPOSING, OF COURSE IF

1410
00:50:36,120 --> 00:50:38,080
YOU CAN DO DRUG REPURPOSING CUT

1411
00:50:38,080 --> 00:50:39,320
THAT TIME LINE TO COUPLE OF

1412
00:50:39,320 --> 00:50:40,640
YEARS AS OPPOSED TO TEN YEARS

1413
00:50:40,640 --> 00:50:42,520
THAT IT TAKES TO DEVELOP DRUGS

1414
00:50:42,520 --> 00:50:44,880
BECAUSE WE KNOW A LOT ABOUT

1415
00:50:44,880 --> 00:50:47,320
THOSE DRUGS BEING REPURPOSED,

1416
00:50:47,320 --> 00:50:50,000
BEEN FDA APPROVED FOR EXAMPLE SO

1417
00:50:50,000 --> 00:50:51,800
OTHER WAYS TO GAIN E FORB SHIES

1418
00:50:51,800 --> 00:50:53,880
SO A LOT OF -- EFFICIENCIES.

1419
00:50:53,880 --> 00:50:55,120
SO THESE ACTIVITIES ARE AROUND

1420
00:50:55,120 --> 00:50:57,560
THAT APPROACH AND GOALS ARE

1421
00:50:57,560 --> 00:50:58,920
ASPIRATIONAL BUT THE WHOLE IDEA

1422
00:50:58,920 --> 00:51:01,240
IS TO BRING MORE TREATMENT TO

1423
00:51:01,240 --> 00:51:01,920
ALL PEOPLE.

1424
00:51:01,920 --> 00:51:04,280
AS I TALK TO OUR INTERNAL TEAM

1425
00:51:04,280 --> 00:51:06,400
MORE ON THESE IDEAS IT IS CLEAR

1426
00:51:06,400 --> 00:51:08,520
TO ME WE CAN MAKE HEADWAY ON

1427
00:51:08,520 --> 00:51:09,120
THEM.

1428
00:51:09,120 --> 00:51:11,760
IMPORTANTLY THE GOALS WE

1429
00:51:11,760 --> 00:51:14,240
FINALIZE WILL GUIDE AND -- US TO

1430
00:51:14,240 --> 00:51:15,600
THE NEXT DECADE AND KEEP US

1431
00:51:15,600 --> 00:51:17,320
FOCUSED ON MAKING THESE GOALS A

1432
00:51:17,320 --> 00:51:17,720
REALITY.

1433
00:51:17,720 --> 00:51:20,360
SO I PLAN TO USE THESE TO ALSO

1434
00:51:20,360 --> 00:51:21,360
HELP FRAME SOME OF THE SUCCESS

1435
00:51:21,360 --> 00:51:23,760
THAT WE HAVE MADE, AND WITH THAT

1436
00:51:23,760 --> 00:51:26,320
I'M INTERESTED IN YOUR THOUGHTS

1437
00:51:26,320 --> 00:51:27,960
ON ALL THINGS WE DO TODAY AN

1438
00:51:27,960 --> 00:51:30,240
ESPECIALLY AROUND THESE THREE

1439
00:51:30,240 --> 00:51:32,320
AMBITIOUS AND AUDACIOUS GOALS.

1440
00:51:32,320 --> 00:51:33,800
I WILL STOP HERE AND I'M GOING

1441
00:51:33,800 --> 00:51:36,120
TO TURN IT OVER TO CLAIRE AND

1442
00:51:36,120 --> 00:51:38,800
PENNY TO MANAGE THE DISCUSSION.

1443
00:51:38,800 --> 00:51:39,360
THANK YOU VERY MUCH.

1444
00:51:39,360 --> 00:51:48,360
I APPRECIATE YOUR ATTENTION.

1445
00:51:48,360 --> 00:51:49,720
>> GREAT, JONI.

1446
00:51:49,720 --> 00:51:52,960
THANKS SO MUCH.

1447
00:51:52,960 --> 00:51:56,120
MS. KENNEDY, WOULD YOU LIKE TO

1448
00:51:56,120 --> 00:51:57,400
VERBALIZE THE COMMENT YOU PUT IN

1449
00:51:57,400 --> 00:52:00,520
THE CHAT BOX?

1450
00:52:00,520 --> 00:52:04,080
>> SURE, I ALSO HAVE A QUESTION

1451
00:52:04,080 --> 00:52:06,920
IF I CAN JUMP IN WITH THAT.

1452
00:52:06,920 --> 00:52:08,600
I WANT TO THANK THOSE WHO ARE

1453
00:52:08,600 --> 00:52:10,040
STEP DOWN FROM THEIR ROLES AND

1454
00:52:10,040 --> 00:52:13,880
NCATS AND ESPECIALLY DR. PARISER

1455
00:52:13,880 --> 00:52:15,920
ONER HER RETIREMENT FROM PUBLIC

1456
00:52:15,920 --> 00:52:19,160
SERVICE AT NCATS AND PREVIOUSLY

1457
00:52:19,160 --> 00:52:21,840
AT FDA WITHOUT A DOUBT HER

1458
00:52:21,840 --> 00:52:24,160
SERVICE CHANGED OUR RARE DISEASE

1459
00:52:24,160 --> 00:52:25,680
LANDSCAPE FOREVER SO I THINK WE

1460
00:52:25,680 --> 00:52:28,840
NEED TO RECOGNIZE THAT AND

1461
00:52:28,840 --> 00:52:30,360
ACKNOWLEDGE THAT WE HAVE A DEPTH

1462
00:52:30,360 --> 00:52:31,160
OF GRATITUDE TO YOU.

1463
00:52:31,160 --> 00:52:33,320
WE ARE REALLY EAGER TO CONTINUE

1464
00:52:33,320 --> 00:52:34,920
TO WORK WITH DR. BROOKS WE KNOW

1465
00:52:34,920 --> 00:52:37,520
A LOT OF MOMENTUM IN ORDR IS

1466
00:52:37,520 --> 00:52:39,120
BECAUSE OF SHARED LEADERSHIP SO

1467
00:52:39,120 --> 00:52:41,120
LOOKING FORWARD TO WORKING WITH

1468
00:52:41,120 --> 00:52:43,120
BOTH OF YOU THROUGHOUT THIS

1469
00:52:43,120 --> 00:52:44,560
TRANSITION AND DR. BROOKS IN THE

1470
00:52:44,560 --> 00:52:45,320
MONTHS AND HOPEFULLY YEARS

1471
00:52:45,320 --> 00:52:45,840
AHEAD.

1472
00:52:45,840 --> 00:52:49,000
THANK YOU.

1473
00:52:49,000 --> 00:52:50,840
I DID HAVE A QUESTION, IF I CAN

1474
00:52:50,840 --> 00:52:54,560
DO THAT AS WELL.

1475
00:52:54,560 --> 00:52:55,800
SO FIRST, THANK YOU FOR THIS

1476
00:52:55,800 --> 00:52:56,800
WONDERFUL PRESENTATION, I FEEL

1477
00:52:56,800 --> 00:52:57,800
LIKE I GET TO MAYBE HEAR YOU

1478
00:52:57,800 --> 00:53:00,360
MONTHLY AND EVERY TIME THERE'S A

1479
00:53:00,360 --> 00:53:02,320
LOT OF NEW INFORMATION THAT YOU

1480
00:53:02,320 --> 00:53:05,840
BRING FORWARD AND A LOT OF GREAT

1481
00:53:05,840 --> 00:53:11,440
PROGRESS.

1482
00:53:11,440 --> 00:53:13,080
A COUPLE OF THINGS YOU PRESENTED

1483
00:53:13,080 --> 00:53:15,520
SPEAKS OUT TO ME AS AGILITY OF

1484
00:53:15,520 --> 00:53:17,200
NCATS AND THE ABILITY TO NCATS

1485
00:53:17,200 --> 00:53:17,680
TO PIVOT.

1486
00:53:17,680 --> 00:53:20,240
ONE EXAMPLE YOU GAVE WAS IN A

1487
00:53:20,240 --> 00:53:22,320
CONVERSATION WITH DR. WOODCOCK,

1488
00:53:22,320 --> 00:53:25,520
A CONCEPT AND IDEA SHE HAD HAS

1489
00:53:25,520 --> 00:53:27,680
NOW COME TO FRUITION AND YOU ARE

1490
00:53:27,680 --> 00:53:31,360
SOON GOING TO HAVE DATA AROUND

1491
00:53:31,360 --> 00:53:35,240
REAL WORLD EVIDENCE.

1492
00:53:35,240 --> 00:53:36,920
UTILIZING MONOCLONAL ANTIBODIES.

1493
00:53:36,920 --> 00:53:38,120
THAT IS A QUICK PIVOT.

1494
00:53:38,120 --> 00:53:39,440
ONE THOUGHT WE DON'T HAVE TO

1495
00:53:39,440 --> 00:53:40,680
ANSWER HERE BUT ONE QUESTION IS

1496
00:53:40,680 --> 00:53:46,720
HOW DO WE BETTER COMMUNICATE NOT

1497
00:53:46,720 --> 00:53:47,920
JURY OUR IMMEDIATE STAKE HOLDERS

1498
00:53:47,920 --> 00:53:49,640
BUT THE GENERAL PUCKLY THE

1499
00:53:49,640 --> 00:53:51,520
IMPACT NCATS HAS ON ANSWERING

1500
00:53:51,520 --> 00:53:53,040
SOME OF OUR URGENT PUBLIC HEALTH

1501
00:53:53,040 --> 00:53:54,320
ISSUES.

1502
00:53:54,320 --> 00:53:56,120
AND ADDRESSING SOME OF THOSE.

1503
00:53:56,120 --> 00:53:59,000
SO THAT SERVES SORT OF STRIKESES

1504
00:53:59,000 --> 00:54:01,560
ME AS NCATS IS ONE OF OUR BEST

1505
00:54:01,560 --> 00:54:03,520
KEPT SECRETS AND ONE OF THE MOST

1506
00:54:03,520 --> 00:54:05,680
POWERFUL RESOURCES AND TOOLS.

1507
00:54:05,680 --> 00:54:07,120
AS YOU WERE PRESENTING THAT

1508
00:54:07,120 --> 00:54:08,440
JUMPED OUT AT ME TIME AND AGAIN.

1509
00:54:08,440 --> 00:54:11,240
THANK YOU FOR THE WORK YOU ARE

1510
00:54:11,240 --> 00:54:11,840
LEADING.

1511
00:54:11,840 --> 00:54:16,440
>> THANK YOU SO MUCH, ANNIE.

1512
00:54:16,440 --> 00:54:20,120
ECHOING YOUR THANKS TO ANN

1513
00:54:20,120 --> 00:54:21,280
PARISER, WHICH I COULDN'T AGREE

1514
00:54:21,280 --> 00:54:22,720
MORE, YOUR QUESTIONS, I DON'T

1515
00:54:22,720 --> 00:54:23,640
KNOW HOW TO ANSWER YOUR

1516
00:54:23,640 --> 00:54:24,520
QUESTION.

1517
00:54:24,520 --> 00:54:29,240
EXCEPT TO SAY THAT AGREE WE NEED

1518
00:54:29,240 --> 00:54:30,520
TO THINK ABOUT WAYS TO

1519
00:54:30,520 --> 00:54:31,720
COMMUNICATE THIS KIND OF

1520
00:54:31,720 --> 00:54:36,200
INFORMATION, I THINK AT THIS

1521
00:54:36,200 --> 00:54:39,440
STAGE HOW WE ARE GATHERING THIS

1522
00:54:39,440 --> 00:54:42,800
INFORMATION AGAIN THE ONE I

1523
00:54:42,800 --> 00:54:44,840
PRESENTED IN THERE WILL BE

1524
00:54:44,840 --> 00:54:45,920
OPPORTUNITIES FOR US TO DO

1525
00:54:45,920 --> 00:54:47,600
CERTAINLY PRESS RELEASES TO GET

1526
00:54:47,600 --> 00:54:50,160
THAT INFORMATION OUT MORE AND

1527
00:54:50,160 --> 00:54:51,360
BUT I THINK THERE IS MORE TO

1528
00:54:51,360 --> 00:54:53,920
LEARN TOO IN TERMS OF HOW WE

1529
00:54:53,920 --> 00:54:55,920
THINK ABOUT WHO IS GOING TO BE

1530
00:54:55,920 --> 00:54:57,520
AT RISK OR HOSPITALIZATION, WHO

1531
00:54:57,520 --> 00:54:59,120
WE NEED TO TARGET FOR THESE

1532
00:54:59,120 --> 00:55:01,680
KINDS OF THERAPIES.

1533
00:55:01,680 --> 00:55:04,520
AND NOT ONLY THAT, YOU MENTIONED

1534
00:55:04,520 --> 00:55:06,120
THE PUBLIC COMMUNICATIONS BUT

1535
00:55:06,120 --> 00:55:08,000
THERE'S ALSO THE PHYSICIAN

1536
00:55:08,000 --> 00:55:09,240
COMMUNICATION, MONOCLONAL

1537
00:55:09,240 --> 00:55:14,920
ANTIBODIES ARE NOT REALLY A

1538
00:55:14,920 --> 00:55:16,440
WIDESPREAD THERAPEUTIC IN MANY

1539
00:55:16,440 --> 00:55:17,880
SPACES SO THERE'S PHYSICIANS WHO

1540
00:55:17,880 --> 00:55:19,640
DON'T KNOW A LOT ABOUT

1541
00:55:19,640 --> 00:55:20,520
MONOCLONAL ANTIBODIES AND HOW

1542
00:55:20,520 --> 00:55:22,520
THEY ARE USED AND WHY USEFUL FOR

1543
00:55:22,520 --> 00:55:23,120
COVID-19.

1544
00:55:23,120 --> 00:55:25,280
SO A LOT OF THE WORK THAT I

1545
00:55:25,280 --> 00:55:29,840
THINK WE ARE FINDING IS HOW DO

1546
00:55:29,840 --> 00:55:31,280
WE DO WE COMMUNICATE TO

1547
00:55:31,280 --> 00:55:32,400
STAKEHOLDERS AND PHYSICIAN

1548
00:55:32,400 --> 00:55:35,720
COMMUNITY SO THEY UNDERSTAND HOW

1549
00:55:35,720 --> 00:55:37,320
TO USE THESE TYPES OF THERAPIES

1550
00:55:37,320 --> 00:55:39,480
AND WHEN TO USE THEM AS WELL,

1551
00:55:39,480 --> 00:55:40,640
RECOGNIZING THAT WITH DIFFERENT

1552
00:55:40,640 --> 00:55:43,360
VIRAL VARIANTS YOU MIGHT HAVE

1553
00:55:43,360 --> 00:55:44,720
DIFFERENT RESPOND -- HAVE

1554
00:55:44,720 --> 00:55:46,080
DIFFERENT RESPONSES TO THE

1555
00:55:46,080 --> 00:55:48,720
MONOCLONAL ANTIBODIES.

1556
00:55:48,720 --> 00:55:51,240
SO THAT IS ONE THING.

1557
00:55:51,240 --> 00:55:52,560
THE OTHER IDEA WE HAVE, I THINK

1558
00:55:52,560 --> 00:55:54,720
WE DO A REALLY GOOD JOB

1559
00:55:54,720 --> 00:55:55,640
COMMUNICATING TO SCIENTIFIC

1560
00:55:55,640 --> 00:55:56,960
COMMUNITY, THROUGH THE OPEN DATA

1561
00:55:56,960 --> 00:55:58,400
PORTAL BECAUSE PEOPLE CAN

1562
00:55:58,400 --> 00:56:01,800
UNDERSTAND HOW TO READ THAT

1563
00:56:01,800 --> 00:56:04,360
INFORMATION BUT WE TRY TO DO A

1564
00:56:04,360 --> 00:56:06,720
GOOD JOB IN HOW WE DISPLAY THAT

1565
00:56:06,720 --> 00:56:09,400
DATA TO MAKE IT AS EASILY

1566
00:56:09,400 --> 00:56:12,320
DIGESTIBLE AS POSSIBLE.

1567
00:56:12,320 --> 00:56:14,000
THE OPEN DATA PORTAL IS A

1568
00:56:14,000 --> 00:56:15,240
WONDERFUL EXAMPLE OF THAT, IT IS

1569
00:56:15,240 --> 00:56:16,880
EASY TO COMMUNICATE THAT.

1570
00:56:16,880 --> 00:56:20,320
THEN THE QUESTION IS HOW DO WE

1571
00:56:20,320 --> 00:56:21,640
THINK ABOUT COMMUNITIES AND I

1572
00:56:21,640 --> 00:56:23,720
WOULD LOVE TO HEAR IDEAS THIS

1573
00:56:23,720 --> 00:56:24,800
GROUP MIGHT HAVE TO BE ABLE TO

1574
00:56:24,800 --> 00:56:29,320
DO MORE OUTREACH ON EDUCATING

1575
00:56:29,320 --> 00:56:31,440
FOLKS AND PERHAPS THAT IS MORE

1576
00:56:31,440 --> 00:56:32,960
WEB PAGES BUT THERE ARE OTHER

1577
00:56:32,960 --> 00:56:33,720
MORE ACTIVE KINDS OF THINGS THAT

1578
00:56:33,720 --> 00:56:37,320
WE CAN DO.

1579
00:56:37,320 --> 00:56:40,560
SO I LIKE THAT IDEA, AS WE

1580
00:56:40,560 --> 00:56:42,880
TALKED ABOUT MORE RECENT DATA

1581
00:56:42,880 --> 00:56:44,680
FROM MONOCLONAL ANTIBODY DATA,

1582
00:56:44,680 --> 00:56:46,720
WE ARE SEEING THAT SAME IDEA OF

1583
00:56:46,720 --> 00:56:49,720
HOW DO WE THINK ABOUT THIS

1584
00:56:49,720 --> 00:56:50,720
INFORMATION OUT THERE,

1585
00:56:50,720 --> 00:56:53,120
DISSEMINATION IS A KEY ASPECTS

1586
00:56:53,120 --> 00:56:53,960
OF WHAT WE DO.

1587
00:56:53,960 --> 00:56:56,760
SO WE ARE TRYING TO FIGURE OUT

1588
00:56:56,760 --> 00:56:57,600
THAT AS WELL.

1589
00:56:57,600 --> 00:57:04,600
THAT IS A VERY GOOD POINT.

1590
00:57:04,600 --> 00:57:07,920
>> DR. CRESLER WOULD YOU LIKE

1591
00:57:07,920 --> 00:57:08,760
THE GO?

1592
00:57:08,760 --> 00:57:11,040
>> THANK YOU FOR SHOWING HOW

1593
00:57:11,040 --> 00:57:13,040
NCATS IS RESPONDING TO THE ACUTE

1594
00:57:13,040 --> 00:57:15,560
NEEDS AT HAND AND STILL KEEP

1595
00:57:15,560 --> 00:57:18,360
LONG TERM STRATEGY IN HAND AND

1596
00:57:18,360 --> 00:57:23,440
REALLY WANT TO 5 TO 25% PUSH FOR

1597
00:57:23,440 --> 00:57:26,640
DEVELOPING TREATMENTS.

1598
00:57:26,640 --> 00:57:28,400
IT SOUNDS AUDACIOUS TO ACTUALLY

1599
00:57:28,400 --> 00:57:29,680
IMPOSSIBLE TO DO AND I WILL

1600
00:57:29,680 --> 00:57:30,440
COUNT ON THAT.

1601
00:57:30,440 --> 00:57:32,280
BECAUSE WHAT WE ARE SEEING RIGHT

1602
00:57:32,280 --> 00:57:37,520
NOW IS THAT WE ARE DEFINING AND

1603
00:57:37,520 --> 00:57:39,280
REDEFINING HOW WE WORK WITH

1604
00:57:39,280 --> 00:57:42,560
HUMANS AS OUR HEAT MAP AND CELL

1605
00:57:42,560 --> 00:57:45,520
BASED -- WE ARE ALIGNING CIVIL

1606
00:57:45,520 --> 00:57:47,360
AND MACHINERY AND MOST

1607
00:57:47,360 --> 00:57:48,720
IMPORTANTLY WHY THEY FAIL.

1608
00:57:48,720 --> 00:57:51,280
WHY IT MIGHT NOT BE POSSIBLE TO

1609
00:57:51,280 --> 00:57:52,720
DEVELOP SPECIFIC TARGETED

1610
00:57:52,720 --> 00:57:55,320
THERAPIES FOR TWO AND A HALF

1611
00:57:55,320 --> 00:57:57,920
THOUSAND DISEASES AND I THINK WE

1612
00:57:57,920 --> 00:57:59,200
HAVE ALL THE INSTRUMENT TIME AT

1613
00:57:59,200 --> 00:58:01,000
HAND AND NCATS HAS THE TOOLS TO

1614
00:58:01,000 --> 00:58:05,600
DEPLOY THEM, TO IDENTIFY SHARE

1615
00:58:05,600 --> 00:58:08,720
COMMON PATHWAYS OF DISEASE

1616
00:58:08,720 --> 00:58:10,480
MANIFESTATIONS WHICH CAN PREVENT

1617
00:58:10,480 --> 00:58:12,520
A LESION WHICH WOULD CAUSE A

1618
00:58:12,520 --> 00:58:14,840
PHENOTYPE IN THE PATIENTS TO

1619
00:58:14,840 --> 00:58:15,440
REMAIN SUB CLINICAL.

1620
00:58:15,440 --> 00:58:17,520
I KNOW THAT THAT HAS BEEN

1621
00:58:17,520 --> 00:58:19,960
DISCUSSED INSIDE NCATS FOR QUITE

1622
00:58:19,960 --> 00:58:23,600
A WHILE IN SEVERAL KNOWLEDGE

1623
00:58:23,600 --> 00:58:24,920
ACTIVITIES, I HEADED THAT WAY

1624
00:58:24,920 --> 00:58:27,440
BUT IT IS RARELY -- REALLY

1625
00:58:27,440 --> 00:58:30,440
IMPRESSIVE TO SEE HOW QUICKLY

1626
00:58:30,440 --> 00:58:31,280
DISEASE SPECIFIC ACTIVITIES IN

1627
00:58:31,280 --> 00:58:33,440
THE CELL MAPPING WE ARE MAKING

1628
00:58:33,440 --> 00:58:37,120
FOCUS TO IDENTIFY THESE PATIENT

1629
00:58:37,120 --> 00:58:38,800
SPECIFIC CHANNELS AND HOW TO

1630
00:58:38,800 --> 00:58:40,480
ENTERPEER WITH THEM IN A TRANS--

1631
00:58:40,480 --> 00:58:41,920
INTERFERE WITH A TRANSLATIONAL

1632
00:58:41,920 --> 00:58:42,120
SENSE.

1633
00:58:42,120 --> 00:58:44,320
THIS IS THE INSTITUTE WHO

1634
00:58:44,320 --> 00:58:46,880
LEVERAGE ALL THEIR KNOWLEDGE AND

1635
00:58:46,880 --> 00:58:51,080
EXOSOME DISCUSSIO DISCUSSIONS
WITH VERY

1636
00:58:51,080 --> 00:58:53,560
SPECIFIC APPLICATION ALREADY BUT

1637
00:58:53,560 --> 00:58:56,240
I THINK WHATEVER YOU CAN PUSH

1638
00:58:56,240 --> 00:58:59,120
BACK, THIS IS JUST ARBITRARY

1639
00:58:59,120 --> 00:59:07,320
NUMBER, NO IT ACTUALLY ISN'T.

1640
00:59:07,320 --> 00:59:10,280
>> 

1641
00:59:10,280 --> 00:59:13,320
>> SORRY ABOUT THAT MA,THIAS.

1642
00:59:13,320 --> 00:59:15,760
THANK YOU SO MUCH FOR THOSE

1643
00:59:15,760 --> 00:59:16,040
COMMENTS.

1644
00:59:16,040 --> 00:59:18,160
I WAS WORRIED TOO THAT IT MIGHT

1645
00:59:18,160 --> 00:59:20,600
BE -- THAT 25% NUMBER MIGHT BE

1646
00:59:20,600 --> 00:59:23,960
TOO BIG BUT AT THE SAME TIME I

1647
00:59:23,960 --> 00:59:24,720
AGREE WITH YOU.

1648
00:59:24,720 --> 00:59:29,320
I THINK WE HAVE TO GO FOR IT.

1649
00:59:29,320 --> 00:59:30,960
YOUR POINT ABOUT THE SUB

1650
00:59:30,960 --> 00:59:32,120
CLINICAL UNDERSTANDING OF THOSE

1651
00:59:32,120 --> 00:59:33,400
END POINTS IS ALSO IMPORTANT AND

1652
00:59:33,400 --> 00:59:36,320
I THINK WITH THE IN VITRO ASSAYS

1653
00:59:36,320 --> 00:59:39,520
THAT WE CAN PUT TOGETHER

1654
00:59:39,520 --> 00:59:41,760
PRINTING AND TISSUE CHIPS WE ARE

1655
00:59:41,760 --> 00:59:43,040
USING, IT IS ALSO TO START

1656
00:59:43,040 --> 00:59:44,320
IDENTIFYING WHAT THE SUB

1657
00:59:44,320 --> 00:59:46,640
CLINICAL PHENOTYPES ARE AS

1658
00:59:46,640 --> 00:59:49,600
BIOMARKERS THAT CAN BECOME

1659
00:59:49,600 --> 00:59:55,320
SOMETHING USED CHUNKILY AND AN

1660
00:59:55,320 --> 00:59:56,720
AREA WE WILL TRY TO DRIVE

1661
00:59:56,720 --> 00:59:59,680
FORWARD AS WELL.

1662
00:59:59,680 --> 01:00:00,680
APPRECIATE YOUR COMMENTS.

1663
01:00:00,680 --> 01:00:02,280
>> THAT WAS TERRIFIC.

1664
01:00:02,280 --> 01:00:05,400
THANK YOU SO MUCH.

1665
01:00:05,400 --> 01:00:07,520
WHAT I WOULD LIKE TO EMPHASIZE,

1666
01:00:07,520 --> 01:00:08,960
WE ARE ALMOST SEEING EMERGENCE

1667
01:00:08,960 --> 01:00:09,720
OF NEW TYPE OF FIELD OF

1668
01:00:09,720 --> 01:00:12,360
MEDICINE.

1669
01:00:12,360 --> 01:00:13,920
WHICH IS AROUND SMALL PATIENT

1670
01:00:13,920 --> 01:00:15,600
GROUP POPULATIONS WHO HAVE YOU

1671
01:00:15,600 --> 01:00:17,720
BEEN SUBDIVIDED BY MOLECULAR AND

1672
01:00:17,720 --> 01:00:19,080
OTHER TYPES AND THE RARE DISEASE

1673
01:00:19,080 --> 01:00:22,160
FIELD THAT I LIVE IN, WE ARE

1674
01:00:22,160 --> 01:00:24,520
LITERALLY SEEING 11 NEW

1675
01:00:24,520 --> 01:00:25,320
CONDITIONS A WEEK.

1676
01:00:25,320 --> 01:00:27,720
WHEN YOU LOOK AT THE LINKING OF

1677
01:00:27,720 --> 01:00:30,160
GENETIC VARIATION TO THAT.

1678
01:00:30,160 --> 01:00:32,280
THAT REALLY DOESN'T FIT THE

1679
01:00:32,280 --> 01:00:33,720
CLASSIC MODEL, THE STATISTICS

1680
01:00:33,720 --> 01:00:35,800
ARE DIFFERENT, THE EVIDENTIARY

1681
01:00:35,800 --> 01:00:36,880
PROOF IS DIFFERENT.

1682
01:00:36,880 --> 01:00:38,320
THE CLINICAL TRIALS MODELS AND

1683
01:00:38,320 --> 01:00:40,720
THERE'S REALLY M CATS IS BETTER

1684
01:00:40,720 --> 01:00:44,840
POSITIONED TO DEAL WITH THIS AND

1685
01:00:44,840 --> 01:00:46,280
TO LEAD THE WAY THAN ANY OTHER

1686
01:00:46,280 --> 01:00:47,320
GROUP.

1687
01:00:47,320 --> 01:00:49,200
BECAUSE IT IS DISEASE AGNOSTIC

1688
01:00:49,200 --> 01:00:50,280
TO A CERTAIN EXTENT.

1689
01:00:50,280 --> 01:00:52,680
THE METHODOLOGIES THAT APPLY TO

1690
01:00:52,680 --> 01:00:54,400
THESE SMALL GROUPS CAN GO ACROSS

1691
01:00:54,400 --> 01:00:56,560
MULTIPLES BUT WE NEED A HOMING

1692
01:00:56,560 --> 01:00:58,920
TOOL -- WE ARE BUILDING A

1693
01:00:58,920 --> 01:00:59,840
TOOLBOX, WE HAVE TO CONTINUE TO

1694
01:00:59,840 --> 01:01:00,880
BUILD THAT.

1695
01:01:00,880 --> 01:01:03,400
SO THE ONLY THING I WOULD ADD ON

1696
01:01:03,400 --> 01:01:06,320
TOP OF THAT VERY GOOD

1697
01:01:06,320 --> 01:01:08,800
PRESENTATION IS BUCKLE UP BUT

1698
01:01:08,800 --> 01:01:11,320
ALSO IT IS VERY IMPORTANT TO

1699
01:01:11,320 --> 01:01:13,360
ENGAGE THE FDA CONSISTENTLY AND

1700
01:01:13,360 --> 01:01:14,960
ACTIVELY.

1701
01:01:14,960 --> 01:01:16,840
BECAUSE IF WE DON'T A LOT OF THE

1702
01:01:16,840 --> 01:01:19,160
WORK THAT WE DO IS GOING TO BE

1703
01:01:19,160 --> 01:01:20,520
WAISTED WHEN PEOPLE HAVE TO GO

1704
01:01:20,520 --> 01:01:25,000
BACK AND USE A DIFFERENT CLASSIC

1705
01:01:25,000 --> 01:01:26,520
MODEL WHEN TAKING TRIALS THROUGH

1706
01:01:26,520 --> 01:01:27,120
FOR APPROVAL.

1707
01:01:27,120 --> 01:01:28,320
>> THAT IS A GREAT POINT,

1708
01:01:28,320 --> 01:01:28,880
MARSHALL.

1709
01:01:28,880 --> 01:01:33,040
THANK YOU FOR BRINGING UP THAT

1710
01:01:33,040 --> 01:01:37,520
SPECIFIC ISSUE AROUND THE FDA

1711
01:01:37,520 --> 01:01:39,960
AND I'M GRATEFUL FOR THE WORK

1712
01:01:39,960 --> 01:01:44,280
THAT THE FDA DOES AND THEY --

1713
01:01:44,280 --> 01:01:46,400
THEY WORK HAND IN HAND WITH US

1714
01:01:46,400 --> 01:01:47,680
ALONG THE WAY.

1715
01:01:47,680 --> 01:01:50,120
CASE IN POINT THAT I WOULD SAY

1716
01:01:50,120 --> 01:01:52,200
IS WITH THE SPOKE GENE THERAPY

1717
01:01:52,200 --> 01:01:53,840
CONSORTIUM, THIS IS ANOTHER ONE

1718
01:01:53,840 --> 01:01:55,160
OF THESE PUBLIC PRIVATE

1719
01:01:55,160 --> 01:01:57,520
PARTNERSHIPS THAT WE DO WITHIN

1720
01:01:57,520 --> 01:01:59,320
THE NIH DUE TO THE ACCELERATED

1721
01:01:59,320 --> 01:02:00,240
MEDICINE PROGRAM.

1722
01:02:00,240 --> 01:02:01,800
FOR THAT PARTICULAR PROGRAM FDA

1723
01:02:01,800 --> 01:02:03,160
IS IN IT FROM THE BEGINNING.

1724
01:02:03,160 --> 01:02:06,840
AND THEY ARE HELPING US BUILD IT

1725
01:02:06,840 --> 01:02:08,280
AND DEVELOP THE FRAMEWORK FOR IT

1726
01:02:08,280 --> 01:02:09,720
BECAUSE IT IS NOT JUST ABOUT THE

1727
01:02:09,720 --> 01:02:11,080
SCIENCE THAT WE NEED TO SUPPORT

1728
01:02:11,080 --> 01:02:17,040
IN TERMS OF UNDERSTANDING THE

1729
01:02:17,040 --> 01:02:18,480
ADENOASSOCIATED VIRAL THERAPIES

1730
01:02:18,480 --> 01:02:21,560
BUT IT IS ALSO THAT WE NEED TO

1731
01:02:21,560 --> 01:02:23,560
FIGURE OUT THAT MODEL OF HOW TO

1732
01:02:23,560 --> 01:02:25,480
WORK THROUGH REGULATORY SPACE SO

1733
01:02:25,480 --> 01:02:28,400
THAT IT IS NOT JUST A ONE OFF,

1734
01:02:28,400 --> 01:02:32,640
IT IS A PLATFORM TECHNOLOGY.

1735
01:02:32,640 --> 01:02:34,240
I THINK THE DISCUSSION WE HAVE

1736
01:02:34,240 --> 01:02:35,720
HAD WITH PETER MARKS AT THE FDA

1737
01:02:35,720 --> 01:02:39,000
HAVE BEEN REALLY EXCITING THAT

1738
01:02:39,000 --> 01:02:40,800
THEY ARE VERY MUCH INTO THAT

1739
01:02:40,800 --> 01:02:42,720
KIND OF IDEA AND WE LOOK FORWARD

1740
01:02:42,720 --> 01:02:48,000
TO WORKING THROUGH THAT THAT

1741
01:02:48,000 --> 01:02:49,520
PLATFORM IN AND OF ITSELF FOR

1742
01:02:49,520 --> 01:02:50,880
SPOKE GENE THERAPY PROGRAM BUT

1743
01:02:50,880 --> 01:02:53,960
IF IT WORKS IT BECOMES A BIGGER

1744
01:02:53,960 --> 01:02:59,280
PLATFORM WHICH YOU CAN APPLY

1745
01:02:59,280 --> 01:03:00,160
OLGONUCLEOTIDE TYPES OR OTHER

1746
01:03:00,160 --> 01:03:02,080
THINGS SO IT WILL BECOME A

1747
01:03:02,080 --> 01:03:02,880
PLATFORM OF PLATFORMS AND I

1748
01:03:02,880 --> 01:03:08,720
THINK THAT'S REALLY EXCITING.

1749
01:03:08,720 --> 01:03:10,800
>> ONE MORE THING TOO, I SAT ON

1750
01:03:10,800 --> 01:03:11,920
COUPLE OF FDA COMMITTEES WHERE

1751
01:03:11,920 --> 01:03:16,760
WE TALK ABOUT HOW WE IN THE

1752
01:03:16,760 --> 01:03:18,120
MODERN AGE HOW WE DO CLINICAL

1753
01:03:18,120 --> 01:03:19,520
TRIALS AROUND THESE.

1754
01:03:19,520 --> 01:03:21,120
THERE'S ANOTHER SIDE TOO, NOT

1755
01:03:21,120 --> 01:03:22,520
JUST WHAT WE ARE GIVING TO

1756
01:03:22,520 --> 01:03:23,680
PATIENTS IS HOW WE ARE TESTING

1757
01:03:23,680 --> 01:03:24,400
THE OUTCOMES.

1758
01:03:24,400 --> 01:03:26,200
WE NEED A NEW SET OF TOOLS THAT

1759
01:03:26,200 --> 01:03:27,720
ARE MORE DESIGNED AROUND

1760
01:03:27,720 --> 01:03:30,920
PATIENTS WHO ARE GEOGRAPHICALLY

1761
01:03:30,920 --> 01:03:32,520
SEPARATED IN OTHER WORDS ONLINE

1762
01:03:32,520 --> 01:03:34,720
DIGITAL TOOLS AND COVID TAUGHT

1763
01:03:34,720 --> 01:03:37,000
US NOTHING ELSE CONCERNING MOST

1764
01:03:37,000 --> 01:03:38,920
EVERY NIH PROTOCOL WAS FULL OF

1765
01:03:38,920 --> 01:03:40,840
PROTOCOL VIOLATIONS BECAUSE

1766
01:03:40,840 --> 01:03:42,480
PATIENTS COULDN'T COME IN ANY

1767
01:03:42,480 --> 01:03:43,920
MORE FOR THINGS BUT NONE OF THE

1768
01:03:43,920 --> 01:03:45,760
TOOLS ARE VALIDATED SO THERE IS

1769
01:03:45,760 --> 01:03:49,320
A LOT OF ROOM FOR PARTNERSHIP ON

1770
01:03:49,320 --> 01:03:50,920
DEVELOPING TOOLS, VALIDATING THE

1771
01:03:50,920 --> 01:03:51,280
TOOLS.

1772
01:03:51,280 --> 01:03:54,120
SO THAT NOT ONLY CAN WE PROVIDE

1773
01:03:54,120 --> 01:03:55,600
PLATFORMS LIKE OUR GENE THERAPY

1774
01:03:55,600 --> 01:03:57,040
BUT ALSO WE HAVE WAYS TO SAY

1775
01:03:57,040 --> 01:03:58,840
OKAY IS IT EFFICACIOUS, AND CAN

1776
01:03:58,840 --> 01:04:00,560
WE DO THAT IN A WAY THAT ISN'T

1777
01:04:00,560 --> 01:04:03,000
GOING TO CRUSH THE FAMILIES AND

1778
01:04:03,000 --> 01:04:03,520
PATIENTS.

1779
01:04:03,520 --> 01:04:04,760
THEY ALREADY GOT ENOUGH ON THEIR

1780
01:04:04,760 --> 01:04:05,400
PLATE ALREADY.

1781
01:04:05,400 --> 01:04:06,440
>> ABSOLUTELY.

1782
01:04:06,440 --> 01:04:09,720
AND AS YOU KNOW, THEY ARE THE

1783
01:04:09,720 --> 01:04:17,280
ONES DOING ALL THE MONEY RAISING

1784
01:04:17,280 --> 01:04:22,200
AND FOR HERMING THOSE PARTICULAR

1785
01:04:22,200 --> 01:04:24,240
DISEASE, IF THIS WORKS IT WOULD

1786
01:04:24,240 --> 01:04:26,320
BE A HUGE BURDEN OFF OF THEIR

1787
01:04:26,320 --> 01:04:26,920
SHOULDERS.

1788
01:04:26,920 --> 01:04:27,640
>> VERY EXCITING.

1789
01:04:27,640 --> 01:04:29,840
THANK YOU.

1790
01:04:29,840 --> 01:04:32,520
>> DR. HARRIS, YOU ARE NEXT.

1791
01:04:32,520 --> 01:04:35,560
>> THANK YOU.

1792
01:04:35,560 --> 01:04:37,480
ECHO OTHER COMMENTS THAT GREAT

1793
01:04:37,480 --> 01:04:39,520
PRESENTATION, LOVE THE GOALS.

1794
01:04:39,520 --> 01:04:41,120
I SORT OF FOCUS ON THE MORE

1795
01:04:41,120 --> 01:04:43,320
PEOPLE AND THINKING ABOUT THE

1796
01:04:43,320 --> 01:04:45,120
FACT THAT GIVEN WORK YOU GUYS

1797
01:04:45,120 --> 01:04:49,880
HAVE DONE WITH N 3C NHLBI HAS

1798
01:04:49,880 --> 01:04:52,680
DONE WITH BIODATA CATALYST AND

1799
01:04:52,680 --> 01:04:54,840
THIS IS A NEW ERA WE ARE IN AND

1800
01:04:54,840 --> 01:04:57,880
IT DEMOCK TIDESES ACCESS TO SOME

1801
01:04:57,880 --> 01:04:59,920
RESOURCES THAT WERE UNHEARD OF A

1802
01:04:59,920 --> 01:05:00,800
DECADE AGO.

1803
01:05:00,800 --> 01:05:03,320
BUT I THINK TO MAKE IT REALLY

1804
01:05:03,320 --> 01:05:04,720
WORK, WE NEED TO THINK ABOUT

1805
01:05:04,720 --> 01:05:06,480
INVESTING IN THE WORK FORCE AND

1806
01:05:06,480 --> 01:05:09,920
MAKING SURE THAT PEOPLE ARE DATA

1807
01:05:09,920 --> 01:05:13,520
PROFICIENT AND INVEST IN WHAT

1808
01:05:13,520 --> 01:05:16,120
YOU CALL TRANSLATORS OR MATCH

1809
01:05:16,120 --> 01:05:18,160
MAKERS, BEING ABLE TO PAIR DATA

1810
01:05:18,160 --> 01:05:19,880
SCIENTISTS WITH CLINICAL EXPERTS

1811
01:05:19,880 --> 01:05:22,000
WITH COMMUNITY ENGAGEMENT

1812
01:05:22,000 --> 01:05:22,600
EXPERTS, ET CETERA.

1813
01:05:22,600 --> 01:05:23,880
THAT IS GOING TO BE NEEDED TO

1814
01:05:23,880 --> 01:05:25,960
TAKE US FROM WHERE WE ARE TO

1815
01:05:25,960 --> 01:05:29,200
WHERE WE COULD BE BUT SO JUST

1816
01:05:29,200 --> 01:05:31,520
ENCOURAGE US ALL TO BE THINKING

1817
01:05:31,520 --> 01:05:32,480
STRATEGICALLY ABOUT THAT SORT OF

1818
01:05:32,480 --> 01:05:34,160
WORK.

1819
01:05:34,160 --> 01:05:36,200
>> GREAT IDEA.

1820
01:05:36,200 --> 01:05:38,120
WITHIN THE N 3C WHAT I DON'T

1821
01:05:38,120 --> 01:05:39,360
TALK ABOUT TOO MUCH IS THERE ARE

1822
01:05:39,360 --> 01:05:42,720
THINGS CALLED DOMAIN TEAMS.

1823
01:05:42,720 --> 01:05:44,720
THE IDEA BEHIND IT, IT'S GETTING

1824
01:05:44,720 --> 01:05:48,360
TO THAT, IT IS ABOUT PAIRING

1825
01:05:48,360 --> 01:05:51,720
STATISTICIAN WITH CLINICIAN ON A

1826
01:05:51,720 --> 01:05:52,720
PARTICULAR OUTCOME THEY MIGHT BE

1827
01:05:52,720 --> 01:05:54,600
LOOKING AT BUT A STATISTICIAN IS

1828
01:05:54,600 --> 01:05:55,720
NOT GOING TO KNOW WHETHER IS

1829
01:05:55,720 --> 01:05:56,800
IMPORTANT IN TERMS OF

1830
01:05:56,800 --> 01:05:57,920
UNDERSTANDING END POINTS SO

1831
01:05:57,920 --> 01:06:00,600
DOING THAT KIND OF PAIRING IS

1832
01:06:00,600 --> 01:06:03,040
GOOD BUT WHAT YOU ARE SAYING IS

1833
01:06:03,040 --> 01:06:04,200
THAT -- THAT MIGHT BE NECESSARY

1834
01:06:04,200 --> 01:06:06,120
BUT IT IS NOT SUFFICIENT.

1835
01:06:06,120 --> 01:06:08,800
I THINK YOU ARE RIGHT, WE HAVE

1836
01:06:08,800 --> 01:06:10,160
BEEN THINKING ABOUT THIS, WE

1837
01:06:10,160 --> 01:06:11,440
HAVE BEEN PARTNERING WITH NIH

1838
01:06:11,440 --> 01:06:12,560
AND THE OFFICE OF DATA SCIENCE

1839
01:06:12,560 --> 01:06:15,480
AND STRATEGY, THEY ARE DOING A

1840
01:06:15,480 --> 01:06:19,120
VARIETY OF PROGRAMS ON SOMETHING

1841
01:06:19,120 --> 01:06:20,480
CALLED IN THE HEAD TRYING TO

1842
01:06:20,480 --> 01:06:21,880
MAKE SURE THEY ARE TOOLS AND

1843
01:06:21,880 --> 01:06:24,520
RESOURCES AVAILABLE FOR ALL

1844
01:06:24,520 --> 01:06:27,920
COMMUNITIES TO BE MORE DATA

1845
01:06:27,920 --> 01:06:29,560
PROFICIENT BUT EVEN THERE I FEAR

1846
01:06:29,560 --> 01:06:32,240
IT IS NECESSARY BUT NOT

1847
01:06:32,240 --> 01:06:34,160
SUFFICIENT SO THAT IS SOMETHING

1848
01:06:34,160 --> 01:06:36,840
TO KEEP UPDATED ON, IT IS A VERY

1849
01:06:36,840 --> 01:06:38,080
ASTUTE POINT AND I WROTE IT

1850
01:06:38,080 --> 01:06:38,400
DOWN.

1851
01:06:38,400 --> 01:06:43,160
THANK YOU.

1852
01:06:43,160 --> 01:06:45,520
>> DR. JACKSON.

1853
01:06:45,520 --> 01:06:47,920
>> HI, JONI.

1854
01:06:47,920 --> 01:06:51,480
THANK YOU FOR THAT OVERVIEW AND

1855
01:06:51,480 --> 01:06:53,320
TOUCHING SOME OF THE HIGHLIGHTS

1856
01:06:53,320 --> 01:06:55,200
OVER THE LAST SEVERAL MONTHS.

1857
01:06:55,200 --> 01:06:57,160
I GUESS I WANT TO FOLLOW-UP ON

1858
01:06:57,160 --> 01:06:57,360
PAUL.

1859
01:06:57,360 --> 01:06:59,240
SO I HAVE TO MAKE SURE I RAISE

1860
01:06:59,240 --> 01:07:02,680
MY HAND BEFORE PAUL SO HE

1861
01:07:02,680 --> 01:07:04,320
DOESN'T FEEL WHAT I WAS GOING SO

1862
01:07:04,320 --> 01:07:06,320
SAY BUT IT IS ALSO AROUND SAME

1863
01:07:06,320 --> 01:07:10,080
CONCEPT OF ALL PEOPLE AND DATA

1864
01:07:10,080 --> 01:07:11,920
DEMOCRATIZATION.

1865
01:07:11,920 --> 01:07:14,160
I WONDER WHAT ARE KIND OF THE

1866
01:07:14,160 --> 01:07:16,120
EFFORTS THAT ARE GOING TO BE

1867
01:07:16,120 --> 01:07:18,920
GOING FORWARD WITH N CATS

1868
01:07:18,920 --> 01:07:22,600
SPECIFICALLY AROUND DATA EQUITY

1869
01:07:22,600 --> 01:07:23,800
ACCESSIBILITY PARTICULARLY FOR

1870
01:07:23,800 --> 01:07:28,440
COMMUNITY STAKEHOLDERS, AND

1871
01:07:28,440 --> 01:07:31,480
OTHERS REDUCING BIAS WITH DATA

1872
01:07:31,480 --> 01:07:32,080
FROM INCEPTION TO FINAL

1873
01:07:32,080 --> 01:07:34,360
ANALYSIS.

1874
01:07:34,360 --> 01:07:37,320
THEN ADDRESSING SOME OF THE

1875
01:07:37,320 --> 01:07:38,680
ISSUES AROUND DIGITAL EQUITY AS

1876
01:07:38,680 --> 01:07:39,120
WELL.

1877
01:07:39,120 --> 01:07:43,520
ARE THESE AREAS THAT NCATS IN

1878
01:07:43,520 --> 01:07:45,560
FACT TAKE SOME LEADERSHIP BOTH

1879
01:07:45,560 --> 01:07:47,800
AROUND THE RARE DISEASE BUT

1880
01:07:47,800 --> 01:07:50,000
BROADLY AROUND TRANSLATIONAL

1881
01:07:50,000 --> 01:07:50,840
SCIENCE, BECAUSE IT IS THE

1882
01:07:50,840 --> 01:07:54,720
QUALITY OF OUR DATA, DON'T

1883
01:07:54,720 --> 01:07:56,760
INCLUDE KIND OF THE BREADTH OF

1884
01:07:56,760 --> 01:07:59,840
OTHER THINGS THAT IMPACT HUMAN

1885
01:07:59,840 --> 01:08:02,840
HEALTH, THEN WE WILL CONTINUE TO

1886
01:08:02,840 --> 01:08:05,720
MAKE ERRORS AS WE MOVE FORWARD

1887
01:08:05,720 --> 01:08:08,920
NOT UNDERSTANDING EVERYTHING

1888
01:08:08,920 --> 01:08:11,960
FROM EXOSOME ALL THE WAY THROUGH

1889
01:08:11,960 --> 01:08:14,040
SOCIAL DETERMINANTS OF HEALTH OR

1890
01:08:14,040 --> 01:08:16,160
EVEN ISSUES ASSOCIATED WITH

1891
01:08:16,160 --> 01:08:18,720
STRUCTURAL RACISM.

1892
01:08:18,720 --> 01:08:22,680
>> THANK YOU FOR BRINGING THAT

1893
01:08:22,680 --> 01:08:23,040
UP.

1894
01:08:23,040 --> 01:08:27,000
THE SHORT ANSWER IS THAT AT

1895
01:08:27,000 --> 01:08:32,080
NCATS WE HAVE JUST STARTED TO --

1896
01:08:32,080 --> 01:08:33,520
MAYBE THIS IS THE LONG ANSWER.

1897
01:08:33,520 --> 01:08:34,800
SHORT ANSWER YES.

1898
01:08:34,800 --> 01:08:37,960
THE LONG ANSWER THOUGH IS MORE

1899
01:08:37,960 --> 01:08:38,320
INTERESTING.

1900
01:08:38,320 --> 01:08:41,560
WE JUST STARTED TO BUILD A

1901
01:08:41,560 --> 01:08:43,480
REALLY DEEP AND WIDE FOCUS ON

1902
01:08:43,480 --> 01:08:44,480
DATA SCIENCE.

1903
01:08:44,480 --> 01:08:48,240
AND WE HAVE A DATA SCIENCE LEAD

1904
01:08:48,240 --> 01:08:54,120
THAT IS MANAGING ACROSS THE

1905
01:08:54,120 --> 01:08:58,120
NCATS AND A LITTLE BIT ABOUT

1906
01:08:58,120 --> 01:08:59,480
WHAT WE HAVE COME UP WITH, WE

1907
01:08:59,480 --> 01:09:01,280
HAD A RETREAT TO TALK ABOUT DATA

1908
01:09:01,280 --> 01:09:03,400
SCIENCE AND WE ARE NOW HAVING A

1909
01:09:03,400 --> 01:09:05,920
FOCUSED EFFORT IN THE TYPES OF

1910
01:09:05,920 --> 01:09:06,760
DATA SETS AND RESOURCES THAT WE

1911
01:09:06,760 --> 01:09:08,760
HAVE.

1912
01:09:08,760 --> 01:09:10,120
ABLE TO MAKE SURE THAT --

1913
01:09:10,120 --> 01:09:10,520
AVAILABLE.

1914
01:09:10,520 --> 01:09:12,120
TO MAKE SURE WE ARE TALKING

1915
01:09:12,120 --> 01:09:14,840
ABOUT THE IDEA OF TRANSPARENCY

1916
01:09:14,840 --> 01:09:16,720
AND WHAT IS IN THE DATA HOW TO

1917
01:09:16,720 --> 01:09:18,880
UNDERSTAND WHAT IS IN THE DATA.

1918
01:09:18,880 --> 01:09:21,320
ALSO TO MAKE SURE THAT WE CAN

1919
01:09:21,320 --> 01:09:22,920
IDENTIFY BIASES IF THEY ARE IN

1920
01:09:22,920 --> 01:09:24,800
THE DATA.

1921
01:09:24,800 --> 01:09:27,120
IF YOU KNOW AND IDENTIFY YOU CAN

1922
01:09:27,120 --> 01:09:27,800
INTERPRET THINGS BETTER.

1923
01:09:27,800 --> 01:09:29,720
THE WHOLE IDEA OF COURSE THEN

1924
01:09:29,720 --> 01:09:31,320
TOO IS UNDERSTAND WHAT BIASES

1925
01:09:31,320 --> 01:09:34,000
ARE SO YOU CAN ADDRESS THEM AND

1926
01:09:34,000 --> 01:09:36,520
BRING MORE DATA INTO EVALUATE

1927
01:09:36,520 --> 01:09:36,720
THAT.

1928
01:09:36,720 --> 01:09:39,800
I WILL SAY ONE OF THE THINGS FOR

1929
01:09:39,800 --> 01:09:42,520
THE N 3C WE HAVE BEEN WORKING

1930
01:09:42,520 --> 01:09:46,400
ON, IS A MORE CONCRETE EXAMPLE

1931
01:09:46,400 --> 01:09:50,560
WE REALLY WANTED TO WORK WITH --

1932
01:09:50,560 --> 01:09:52,320
BECAUSE THE DATA TYPES THEY ARE

1933
01:09:52,320 --> 01:09:54,120
BRINGING IN ARE AREAS MORE

1934
01:09:54,120 --> 01:09:55,480
UNDERSERVED SO WE WANTED TO MAKE

1935
01:09:55,480 --> 01:09:57,640
SURE WE -- THAT TYPE OF DATA WAS

1936
01:09:57,640 --> 01:10:00,720
REPRESENTED IN THE N 3C COHORT.

1937
01:10:00,720 --> 01:10:02,320
EVEN THEN I THINK WE STILL NEED

1938
01:10:02,320 --> 01:10:03,520
TO DO A BETTER JOB AND ENSURE

1939
01:10:03,520 --> 01:10:08,520
THAT WE ARE GETTING THAT

1940
01:10:08,520 --> 01:10:09,240
DISTRIBUTION AND REPRESENTATION

1941
01:10:09,240 --> 01:10:10,640
OF THE UNITED STATES SO THAT WE

1942
01:10:10,640 --> 01:10:14,440
HAVE THAT DATA TRANSPARENCY SO

1943
01:10:14,440 --> 01:10:17,240
THAT THINGS WE INTERPRET FROM

1944
01:10:17,240 --> 01:10:19,120
THE STUDIES THAT WE DO ARE

1945
01:10:19,120 --> 01:10:20,640
GENERALIZABLE IN A WAY.

1946
01:10:20,640 --> 01:10:21,520
AND I THINK THAT IS SO

1947
01:10:21,520 --> 01:10:22,560
IMPORTANT.

1948
01:10:22,560 --> 01:10:24,480
AND THIS GOES BACK TO WHY I

1949
01:10:24,480 --> 01:10:27,040
THINK I'M EXCITED ABOUT THE

1950
01:10:27,040 --> 01:10:28,440
TRIBAL CONSULTATION WE ARE ABOUT

1951
01:10:28,440 --> 01:10:30,120
TO HAVE THAWS BAY IS ANOTHER

1952
01:10:30,120 --> 01:10:31,760
AREA WE NEED TO BOLSTER AND

1953
01:10:31,760 --> 01:10:34,400
SUPPORT BUT ALSO RECOGNIZE THAT

1954
01:10:34,400 --> 01:10:36,280
THE -- THEY HAVE TRIBAL

1955
01:10:36,280 --> 01:10:37,600
SOVEREIGNTY OVER DATA THEY HAVE.

1956
01:10:37,600 --> 01:10:39,240
AND WE WANT TO MAKE SURE WE ARE

1957
01:10:39,240 --> 01:10:40,120
HONORING THAT AND RECOGNIZING

1958
01:10:40,120 --> 01:10:41,720
THAT.

1959
01:10:41,720 --> 01:10:44,080
SO WE WANT TO USE THAT VERY

1960
01:10:44,080 --> 01:10:45,880
WELL, AND SO THAT THAT COMMUNITY

1961
01:10:45,880 --> 01:10:47,320
THEN CAN TAKE A LOOK AT THE DATA

1962
01:10:47,320 --> 01:10:50,240
AND APPLY IT NECESSARILY TO HELP

1963
01:10:50,240 --> 01:10:51,640
THEM THINK ABOUT WHAT KINDS OF

1964
01:10:51,640 --> 01:10:54,240
RESOURCES THEY MIGHT NEED GIVEN

1965
01:10:54,240 --> 01:10:56,560
SPECIFIC SCENARIOS IN THAT

1966
01:10:56,560 --> 01:10:58,120
COMMUNITY AND THINK ABOUT DOING

1967
01:10:58,120 --> 01:10:58,840
THAT AS WELL.

1968
01:10:58,840 --> 01:11:00,520
SO THIS IDEA OF BIAS IS

1969
01:11:00,520 --> 01:11:02,080
SOMETHING WE THINK ABOUT AND

1970
01:11:02,080 --> 01:11:04,520
TALK ABOUT A LOT AND I AM --

1971
01:11:04,520 --> 01:11:06,200
THIS IS -- I THINK OVER THE NEXT

1972
01:11:06,200 --> 01:11:08,520
YEAR AT N CATS DATA SCIENCE AND

1973
01:11:08,520 --> 01:11:09,800
THIS PARTICULAR IDEA IS ONE OF

1974
01:11:09,800 --> 01:11:11,120
THE BIGGER THINGS THAT WE WILL

1975
01:11:11,120 --> 01:11:16,840
BE FOCUSING ON.

1976
01:11:16,840 --> 01:11:18,720
>> MS. HARTMAN YOU ARE NEXT.

1977
01:11:18,720 --> 01:11:25,640
>> THANK YOU.

1978
01:11:25,640 --> 01:11:28,640
>> FEW FOR THE FAIR WELL, I'M

1979
01:11:28,640 --> 01:11:30,680
SAD THIS IS MY LAST MEETING BUT

1980
01:11:30,680 --> 01:11:31,920
LOOK FORWARD TO WORKING WITH ALL

1981
01:11:31,920 --> 01:11:34,200
OF YOU MANY LEADING GOVERNMENT

1982
01:11:34,200 --> 01:11:36,680
AFFAIRS FOR ALLIANCE FOR

1983
01:11:36,680 --> 01:11:37,960
REGENERATIVE MEDICINE SO STILL

1984
01:11:37,960 --> 01:11:41,720
IN THIS SPACE BUT I WANT TO

1985
01:11:41,720 --> 01:11:44,440
COMMENT MORE WEARING MY HAT AS A

1986
01:11:44,440 --> 01:11:45,800
RARE MOM, ONE OF THE MOST

1987
01:11:45,800 --> 01:11:47,760
IMPORTANT THINGS I HAVE SEEN

1988
01:11:47,760 --> 01:11:51,960
WORKING WITH NCATS HAS BEEN

1989
01:11:51,960 --> 01:11:52,680
CHAMPIONSHIP RARE DISEASE.

1990
01:11:52,680 --> 01:11:53,880
ANNIE SAID QUITE A BIT ABOUT

1991
01:11:53,880 --> 01:11:55,560
THIS AND ECHOED COMMENTS AND

1992
01:11:55,560 --> 01:11:58,600
SAME WITH MARSHALL SUMMERS RARE

1993
01:11:58,600 --> 01:12:00,320
IS A PUBLIC HEALTH PRIORITY.

1994
01:12:00,320 --> 01:12:02,120
THIS HAS BEEN AN ISSUE THAT WE

1995
01:12:02,120 --> 01:12:05,600
HAVE BEEN TRYING TO PUSH WITH

1996
01:12:05,600 --> 01:12:08,400
THE ASSISTANCE FUND WORKING

1997
01:12:08,400 --> 01:12:10,360
CLOSELY WITH DR. SUMMER AND

1998
01:12:10,360 --> 01:12:11,520
CHILDREN'S NATIONAL WORKING

1999
01:12:11,520 --> 01:12:13,080
CLOSELY WITH ANNIE KENNEDY AND

2000
01:12:13,080 --> 01:12:14,720
HER COLLEAGUES AT THE EVERY LIFE

2001
01:12:14,720 --> 01:12:15,720
FOUNDATION AND THE REST OF THE

2002
01:12:15,720 --> 01:12:18,720
RARE DISEASE COMMUNITY.

2003
01:12:18,720 --> 01:12:22,160
NCATS HAS ALWAYS BEEN THE

2004
01:12:22,160 --> 01:12:25,000
BIGGEST CHAMPION FOR RARE

2005
01:12:25,000 --> 01:12:25,240
DISEASE.

2006
01:12:25,240 --> 01:12:26,640
JONI YOUR LEADERSHIP IN THIS

2007
01:12:26,640 --> 01:12:28,400
SPACE IS CRITICAL AND WE HOPE

2008
01:12:28,400 --> 01:12:30,720
THIS WILL CONTINUE.

2009
01:12:30,720 --> 01:12:32,440
PERSONALLY AND PROFESSIONALLY

2010
01:12:32,440 --> 01:12:33,320
VERY IMPORTANT TO ME THAT THIS

2011
01:12:33,320 --> 01:12:36,120
CONTINUES.

2012
01:12:36,120 --> 01:12:39,160
I KNOW WE WILL HEAR FROM TARA ON

2013
01:12:39,160 --> 01:12:41,160
ARPA H AND THIS IS AN ISSUE THE

2014
01:12:41,160 --> 01:12:42,560
RARE COMMUNITY IS FOCUSED ON HOW

2015
01:12:42,560 --> 01:12:44,160
TO ENSURE THAT RARE DISEASES ARE

2016
01:12:44,160 --> 01:12:48,240
ALSO PRIORITIZED WITHIN ARPA H

2017
01:12:48,240 --> 01:12:50,600
THE RARE DISEASE COMMUNITY THE

2018
01:12:50,600 --> 01:12:51,800
ASSISTANCE FUND EVERY LIFE

2019
01:12:51,800 --> 01:12:54,560
GLOBAL GENES RARE -- THE WHOLE

2020
01:12:54,560 --> 01:12:58,040
SLEW OF ORGANIZATIONS PUT A

2021
01:12:58,040 --> 01:12:59,440
WHITE PAPER TOGETHER, HAPPY TO

2022
01:12:59,440 --> 01:13:01,400
SHARE IF YOU HAVEN'T SEEN IT, IT

2023
01:13:01,400 --> 01:13:03,720
IS VERY SHORT BUT OUTLINES WHAT

2024
01:13:03,720 --> 01:13:05,120
RARE DISEASE COMMUNITY WOULD

2025
01:13:05,120 --> 01:13:09,520
LIKE TO SEE, ARPA H FOCUS ON AND

2026
01:13:09,520 --> 01:13:14,920
WORK WITH NCATS GOING FORWARD.

2027
01:13:14,920 --> 01:13:16,040
SOME OF THE RARE PARENTS AND I

2028
01:13:16,040 --> 01:13:17,200
HAVE HAD A THE CUSHION ABOUT

2029
01:13:17,200 --> 01:13:19,800
WHAT WAS RAISED IN -- DISCUSSION

2030
01:13:19,800 --> 01:13:21,600
ABOUT WHAT WAS RAISED IN TERMS

2031
01:13:21,600 --> 01:13:23,760
OF NIH AND FDA WORK CLOSE

2032
01:13:23,760 --> 01:13:24,720
TOGETHER AND MAKING SURE THEY

2033
01:13:24,720 --> 01:13:28,760
ARE WORKING WITH CMS SO THAT

2034
01:13:28,760 --> 01:13:30,680
ONCE THESE DRUGS HIT THE MARKET

2035
01:13:30,680 --> 01:13:32,320
PATIENTS CAN ACCESS THEM AS WELL

2036
01:13:32,320 --> 01:13:33,680
AND THAT IS SOMETHING WE SPENT

2037
01:13:33,680 --> 01:13:35,720
TIME ON AT THE ASSISTANCE FUND.

2038
01:13:35,720 --> 01:13:37,800
WHEN IT COMES TO EVEN GETTING

2039
01:13:37,800 --> 01:13:39,080
THESE DRUGS INTO THE PIPELINE

2040
01:13:39,080 --> 01:13:43,920
AND THROUGH THE FDA, ONE

2041
01:13:43,920 --> 01:13:44,920
CONVERSATION WE HAVE BEEN HAVING

2042
01:13:44,920 --> 01:13:46,080
AS CAREGIVERS OF RARE DISEASE

2043
01:13:46,080 --> 01:13:47,440
QUITE A BIT IS THE NEED FOR A

2044
01:13:47,440 --> 01:13:49,400
NEW LOOK AT THE RISK CALCULATION

2045
01:13:49,400 --> 01:13:53,480
THAT FDA IS USING.

2046
01:13:53,480 --> 01:13:54,760
THIS IS SOMETHING A LOT OF US

2047
01:13:54,760 --> 01:13:56,480
HAVE SPOKEN PUBLICLY ABOUT BUT

2048
01:13:56,480 --> 01:13:58,480
THERE NEEDS TO BE A LARGER

2049
01:13:58,480 --> 01:13:58,840
CONVERSATION.

2050
01:13:58,840 --> 01:14:01,800
WHEN CHILDREN ARE DYING, THAT IS

2051
01:14:01,800 --> 01:14:05,800
SOMETHING THAT THE FDA DOES

2052
01:14:05,800 --> 01:14:06,320
UNDERSTAND.

2053
01:14:06,320 --> 01:14:08,600
MANY OF YOU MAY REALIZE WITH MY

2054
01:14:08,600 --> 01:14:10,600
SITUATION MY DAUGHTER HAS A

2055
01:14:10,600 --> 01:14:11,440
SEVERE DEVELOPMENTAL DISABILITY.

2056
01:14:11,440 --> 01:14:13,960
SO SHE'S ESSENTIALLY A PERPETUAL

2057
01:14:13,960 --> 01:14:15,240
TODDLER, SHE CAN BARELY WALK,

2058
01:14:15,240 --> 01:14:17,280
SHE CAN'T TALK, SHE'S GOING TO

2059
01:14:17,280 --> 01:14:19,120
BE SIX SOON, SHE CANNOT COMPLETE

2060
01:14:19,120 --> 01:14:20,960
ANY OF THE ACTIVITIES OF DAILY

2061
01:14:20,960 --> 01:14:21,800
LIVING WITHOUT ASSISTANCE.

2062
01:14:21,800 --> 01:14:24,280
IT IS VERY MUCH LIFE ALTERING.

2063
01:14:24,280 --> 01:14:26,400
THE RISK CALCULATION FOR US IS

2064
01:14:26,400 --> 01:14:29,120
ALSO VERY DIFFERENT.

2065
01:14:29,120 --> 01:14:33,040
WE -- THERE WAS JUST A

2066
01:14:33,040 --> 01:14:37,120
CONVERSATION THAT LUKE ROSEN

2067
01:14:37,120 --> 01:14:38,640
RELEASED ABOUT HOW CAREGIVERS

2068
01:14:38,640 --> 01:14:40,960
WOULD LIKE TO TIME OUR LEAVING

2069
01:14:40,960 --> 01:14:42,960
THIS PLANET WITH OUR CHILDREN

2070
01:14:42,960 --> 01:14:43,960
BECAUSE THE THOUGHT OF LEAVING

2071
01:14:43,960 --> 01:14:45,920
THEM HERE ALONE IS TERRIFYING

2072
01:14:45,920 --> 01:14:47,560
BECAUSE WE ARE NOT SET UP IN

2073
01:14:47,560 --> 01:14:51,080
THIS SOCIETY TO CARE FOR THEM.

2074
01:14:51,080 --> 01:14:53,040
IT IS IMPORTANT TO CONSIDER THIS

2075
01:14:53,040 --> 01:14:54,600
RISK CALCULATION.

2076
01:14:54,600 --> 01:14:56,840
FOR THESE CHILDREN AS WELL.

2077
01:14:56,840 --> 01:14:59,640
BECAUSE RIGHT NOW, WE DON'T HAVE

2078
01:14:59,640 --> 01:15:00,480
A GOOD SOLUTION.

2079
01:15:00,480 --> 01:15:02,800
A LOT OF US ARE AWAKE A LOT OF

2080
01:15:02,800 --> 01:15:04,840
NIGHTS THINKING ABOUT THIS.

2081
01:15:04,840 --> 01:15:07,160
THE HOPE THAT THE SCIENCE WILL

2082
01:15:07,160 --> 01:15:09,520
MOVE FORWARD IS CRITICAL.

2083
01:15:09,520 --> 01:15:11,920
I'M ALSO HOPEFUL THAT WE'LL DO

2084
01:15:11,920 --> 01:15:13,800
MORE WORK AND THIS IS NOT NCATS

2085
01:15:13,800 --> 01:15:15,520
JOB BUT LOOKING HOW WE DO TAKE

2086
01:15:15,520 --> 01:15:19,320
CARE OF THESE CHILDREN.

2087
01:15:19,320 --> 01:15:23,640
THERE IS NOT ENOUGH OF THE -- IN

2088
01:15:23,640 --> 01:15:25,160
THE WORLD TO CARE FOR THEM.

2089
01:15:25,160 --> 01:15:27,840
WE DON'T WANT TO HAVE ANOTHER

2090
01:15:27,840 --> 01:15:28,520
WILLOW BUTCH, THE INSTITUTION

2091
01:15:28,520 --> 01:15:31,880
WHERE THEY ARE NOW DOING MY

2092
01:15:31,880 --> 01:15:32,440
DAUGHTERS UNNATURAL HISTORY

2093
01:15:32,440 --> 01:15:34,680
STUDY TRANSFORMED SINCE THE

2094
01:15:34,680 --> 01:15:37,240
'80s.

2095
01:15:37,240 --> 01:15:38,840
THESE ARE THINGS THAT NEED TO BE

2096
01:15:38,840 --> 01:15:40,840
BROUGHT INTO THE OPEN.

2097
01:15:40,840 --> 01:15:42,120
WE NEED DISCUSSION WITH THE

2098
01:15:42,120 --> 01:15:45,240
PARENTS AND WITH THE CAREGIVERS.

2099
01:15:45,240 --> 01:15:47,280
S ESPECIALLY FOR CHILDREN BRAIN

2100
01:15:47,280 --> 01:15:48,960
ARE NOT WORKING CORRECTLY AND

2101
01:15:48,960 --> 01:15:50,480
CANNOT SPEAK OR THINK FOR

2102
01:15:50,480 --> 01:15:50,880
THEMSELVES.

2103
01:15:50,880 --> 01:15:52,600
IT IS A SOCIETAL QUESTION.

2104
01:15:52,600 --> 01:15:54,680
THAT I THINK WE REALLY NEED TO

2105
01:15:54,680 --> 01:15:55,400
ADDRESS.

2106
01:15:55,400 --> 01:15:57,640
ONE LAST THING, MY RESEARCH

2107
01:15:57,640 --> 01:15:59,840
EMAILED US WORKING ON THE ARPA H

2108
01:15:59,840 --> 01:16:02,120
GETTING PRY YOUR PHASE FOR ARPA

2109
01:16:02,120 --> 01:16:03,520
H, HE SAID COLLEAGUES WERE

2110
01:16:03,520 --> 01:16:05,200
ASKING HIM WHY WOULD WE FOCUS ON

2111
01:16:05,200 --> 01:16:05,920
RARE DISEASES?

2112
01:16:05,920 --> 01:16:08,920
WHY WOULDN'T WE FOCUS ON SOME

2113
01:16:08,920 --> 01:16:09,880
MORE COMMON DISEASES?

2114
01:16:09,880 --> 01:16:12,320
AND WHAT ALL OF US DISCUSSED

2115
01:16:12,320 --> 01:16:15,720
AGAIN OFFLINE QUITE A BIT IS WE

2116
01:16:15,720 --> 01:16:18,360
WOULD KILL FOR CORTICOSTEROIDS

2117
01:16:18,360 --> 01:16:21,160
IF OUR KIDS HAD ASTHMA, KILL FOR

2118
01:16:21,160 --> 01:16:22,200
INSULIN PUMPS LIKE IF YOU ARE

2119
01:16:22,200 --> 01:16:23,840
DEALING WITH DIABETES, NOT TO

2120
01:16:23,840 --> 01:16:25,680
SAY WE CAN'T DO BETTER IN THOSE

2121
01:16:25,680 --> 01:16:28,320
SPACES BUT IF YOU CAN PERFORM

2122
01:16:28,320 --> 01:16:30,120
BASIC ACTIVITIES OF DAILY

2123
01:16:30,120 --> 01:16:30,880
LIVING, YOU HAVE GOT A HUGE STEP

2124
01:16:30,880 --> 01:16:33,360
UP.

2125
01:16:33,360 --> 01:16:35,280
SO I THINK WE CAN DO MORE WORK

2126
01:16:35,280 --> 01:16:38,120
TO TRY TO GET PEOPLE TO THAT

2127
01:16:38,120 --> 01:16:39,400
PLACE WHERE THEY CAN FUNCTION AT

2128
01:16:39,400 --> 01:16:42,360
EVEN BASIC LEVEL IN SOCIETY AND

2129
01:16:42,360 --> 01:16:44,120
THAT'S THE HOPE THE SCIENCE AND

2130
01:16:44,120 --> 01:16:45,840
NCATS IS BRINGING TO US BUT I

2131
01:16:45,840 --> 01:16:48,680
REALLY DO THINK BENEED TO HAVE

2132
01:16:48,680 --> 01:16:50,360
NCATS PULL IN, YOU HAVE BEEN

2133
01:16:50,360 --> 01:16:51,560
GOOD AT THIS, THE PATIENT

2134
01:16:51,560 --> 01:16:53,280
CAREGIVER COMMUNITIES, MAKE SURE

2135
01:16:53,280 --> 01:16:55,120
FDA IS REALLY LISTENING, MAKE

2136
01:16:55,120 --> 01:16:57,000
SURE CMS IS REALLY LISTENING THE

2137
01:16:57,000 --> 01:16:58,560
WHITE HOUSE IS LISTENING, AND

2138
01:16:58,560 --> 01:17:00,000
THAT WE ARE MOVING THIS FIELD

2139
01:17:00,000 --> 01:17:04,520
FORWARD AND WE ARE TAKING INTO

2140
01:17:04,520 --> 01:17:05,920
ACCOUNT THAT PERSPECTIVE WHEN

2141
01:17:05,920 --> 01:17:06,920
THINKING ABOUT RISK.

2142
01:17:06,920 --> 01:17:08,640
ONE LAST THING, IN TERMS OF THE

2143
01:17:08,640 --> 01:17:10,480
DATA DEMOCRATIZATION, I AGREE

2144
01:17:10,480 --> 01:17:14,120
THAT IS SO CRITICAL.

2145
01:17:14,120 --> 01:17:18,040
AND I'M THRILLED MY DAUGHTERS

2146
01:17:18,040 --> 01:17:19,400
DISEASE DAY IS PARTICIPATING IN

2147
01:17:19,400 --> 01:17:20,760
RARE X.

2148
01:17:20,760 --> 01:17:22,320
THE DATA IS OWN AND AVAILABLE

2149
01:17:22,320 --> 01:17:23,880
AND PATIENTS AND THEIR FAMILIES

2150
01:17:23,880 --> 01:17:27,320
MAKE THE DECISION TO SHARE IT

2151
01:17:27,320 --> 01:17:28,960
AND EVENTUALLY, I DON'T WANT TO

2152
01:17:28,960 --> 01:17:30,720
PUT KELLY ON THE SPOT BUT SHE'S

2153
01:17:30,720 --> 01:17:33,120
BEEN LEADING A LOT IN MAKING

2154
01:17:33,120 --> 01:17:34,640
SURE,IOTONLY THAT PATIENTS OWN

2155
01:17:34,640 --> 01:17:36,640
THEIR DATA BUT THAT THEY GET

2156
01:17:36,640 --> 01:17:43,360
COMPENSATED FOR THEIR DATA.

2157
01:17:43,360 --> 01:17:44,520
THAT IS IMPORTANT GOING TO THE

2158
01:17:44,520 --> 01:17:44,920
FUTURE.

2159
01:17:44,920 --> 01:17:48,640
WE KNOW THE STORY OF HENRY

2160
01:17:48,640 --> 01:17:50,080
LACKS, IF THE PATIENTS

2161
01:17:50,080 --> 01:17:51,520
THEMSELVES ARE THE ONES

2162
01:17:51,520 --> 01:17:52,520
GENERATING THESE MILLIONS AND

2163
01:17:52,520 --> 01:17:54,480
BILLIONS OF DOLLARS THAT SOME OF

2164
01:17:54,480 --> 01:17:56,040
THOSE RESOURCES ARE COMING BACK

2165
01:17:56,040 --> 01:17:59,400
FOR WHAT THEY PUT IN.

2166
01:17:59,400 --> 01:18:00,120
THAT IT SEEMS TO ME TWO CENTS,

2167
01:18:00,120 --> 01:18:01,800
HAPPY TO SHARE THE ARPA H WHITE

2168
01:18:01,800 --> 01:18:03,760
PAPER BUT I THINK NCATS IS

2169
01:18:03,760 --> 01:18:05,120
WELL-POSITIONED TO KEEP LEADING

2170
01:18:05,120 --> 01:18:06,880
THIS DISCUSSION AND MOVING IT

2171
01:18:06,880 --> 01:18:09,120
INTO THE 21ST CENTURY AND

2172
01:18:09,120 --> 01:18:10,560
HOPEFULLY WILL HAVE 21ST SENT

2173
01:18:10,560 --> 01:18:11,680
ARE I TREATMENTS AND CURES

2174
01:18:11,680 --> 01:18:14,080
HITTING THE MARKET AND AVAILABLE

2175
01:18:14,080 --> 01:18:15,760
FOR KIDS LIKE MY DAUGHTER AND

2176
01:18:15,760 --> 01:18:16,160
MORE.

2177
01:18:16,160 --> 01:18:17,400
THANK YOU.

2178
01:18:17,400 --> 01:18:20,360
>> THANK YOU SO MUCH, REINFORCES

2179
01:18:20,360 --> 01:18:21,840
WHY WE ARE GOING TO MISS YOU SO

2180
01:18:21,840 --> 01:18:23,120
MUCH ON COUNCIL.

2181
01:18:23,120 --> 01:18:25,880
HUE FOR JOINING US TODAY.

2182
01:18:25,880 --> 01:18:27,320
VERY WELL SAID.

2183
01:18:27,320 --> 01:18:30,760
ALL OF IT WAS WELL SAID AND WE

2184
01:18:30,760 --> 01:18:32,120
DO HAVE TINA MORRISON HERE, I

2185
01:18:32,120 --> 01:18:33,680
DON'T WANT IF YOU WANT TO

2186
01:18:33,680 --> 01:18:35,800
RESPOND QUICKLY, YOU HAVE A

2187
01:18:35,800 --> 01:18:36,400
COMMENT IN THE BOX.

2188
01:18:36,400 --> 01:18:38,320
DO YOU WANT TO SAY SOMETHING AND

2189
01:18:38,320 --> 01:18:38,960
UNMUTE YOURSELF?

2190
01:18:38,960 --> 01:18:40,240
>> THANKS FOR THE CHANCE, I

2191
01:18:40,240 --> 01:18:40,720
APPRECIATE IT.

2192
01:18:40,720 --> 01:18:41,920
CAN YOU HEAR ME OKAY?

2193
01:18:41,920 --> 01:18:42,360
>> WE CAN.

2194
01:18:42,360 --> 01:18:46,800
YES.

2195
01:18:46,800 --> 01:18:48,520
>> I AM GOING TO SHARE A LINK

2196
01:18:48,520 --> 01:18:49,680
FROM THE RECENT SUMMIT SPONSORED

2197
01:18:49,680 --> 01:18:51,960
BY THE CENTERS OF EXCELLENCE AND

2198
01:18:51,960 --> 01:18:52,680
REGULATORY SCIENCE AND

2199
01:18:52,680 --> 01:18:53,000
INNOVATION.

2200
01:18:53,000 --> 01:18:54,360
THERE WAS A REALLY IMPORTANT

2201
01:18:54,360 --> 01:18:58,520
PANEL DISCUSSION WITH FIVE FDA

2202
01:18:58,520 --> 01:19:00,120
COMMISSIONERS THE CURRENT ACTING

2203
01:19:00,120 --> 01:19:01,360
COMMISSIONER MODERATED THE

2204
01:19:01,360 --> 01:19:04,120
SESSION JANET WOODCOCK AND ONE

2205
01:19:04,120 --> 01:19:04,920
FASCINATING PIECE OF THE

2206
01:19:04,920 --> 01:19:07,920
DISCUSSION WAS FOCUSING ON RARE

2207
01:19:07,920 --> 01:19:09,320
DISEASE, TALKING ABOUT OUR

2208
01:19:09,320 --> 01:19:11,400
RELATIONSHIP WITH CMS, AND

2209
01:19:11,400 --> 01:19:14,360
PAYERS TO REALLY THINK ABOUT

2210
01:19:14,360 --> 01:19:18,040
WHAT STRUCK ME JONI IN YOUR

2211
01:19:18,040 --> 01:19:18,800
COMMENTS ABOUT GETTING MORE

2212
01:19:18,800 --> 01:19:20,840
TREATMENT TO ALL PATIENTS, OR

2213
01:19:20,840 --> 01:19:23,600
ALL PEOPLE, I FORGET YOUR EXACT

2214
01:19:23,600 --> 01:19:24,880
VISION BUT THE THING THAT CAME

2215
01:19:24,880 --> 01:19:28,560
TO MY MIND IS WE CAN DEVELOP THE

2216
01:19:28,560 --> 01:19:33,080
TREATMENTS BUT WHAT IS THE ROLE

2217
01:19:33,080 --> 01:19:34,960
OF NCATS AND HOW TO GET TO THE

2218
01:19:34,960 --> 01:19:36,320
PATIENT AND A LOT OF THAT HAS TO

2219
01:19:36,320 --> 01:19:37,960
DO WITH PAYERS AND CONVERSATION

2220
01:19:37,960 --> 01:19:39,520
WITH START WITH CMS AND JUST

2221
01:19:39,520 --> 01:19:41,840
THINKING THE ROLE FDA CAN PLAY

2222
01:19:41,840 --> 01:19:44,120
IN HELPING THAT AND I KNOW THAT

2223
01:19:44,120 --> 01:19:48,120
FDA HAS WORKED MY PAST

2224
01:19:48,120 --> 01:19:49,080
EXPERIENCES COME FROM

2225
01:19:49,080 --> 01:19:50,840
(INAUDIBLE) I WAS A REGULATOR

2226
01:19:50,840 --> 01:19:52,400
THERE FOR SEVERAL YEARS.

2227
01:19:52,400 --> 01:19:54,520
WE CONSTANTLY TALKED ABOUT THIS

2228
01:19:54,520 --> 01:19:56,680
CONVERSATION THAT NEEDS TO

2229
01:19:56,680 --> 01:19:59,080
HAPPEN BETWEEN FDA AND CMS AS A

2230
01:19:59,080 --> 01:20:00,800
START TO SAY WHAT IS THE DATA

2231
01:20:00,800 --> 01:20:01,320
FDA NEEDS?

2232
01:20:01,320 --> 01:20:04,320
WHAT IS THE DATA CMS NEEDS?

2233
01:20:04,320 --> 01:20:09,040
IS THERE WAY TO WORK TOGETHER SO

2234
01:20:09,040 --> 01:20:10,360
THAT ONCE SOMETHING LEAVES FDA

2235
01:20:10,360 --> 01:20:12,040
AND LANDS ON CMS DESK IS THERE A

2236
01:20:12,040 --> 01:20:13,280
WAY FOR US TO ANSWER THOSE

2237
01:20:13,280 --> 01:20:14,600
QUESTIONS FOR THEM IN THAT

2238
01:20:14,600 --> 01:20:16,160
PASSING OF THE BATON WHERE WE

2239
01:20:16,160 --> 01:20:20,120
WORK TOGETHER WHEN BATON IS

2240
01:20:20,120 --> 01:20:22,080
PASSED AND WE SUPPORT CMS

2241
01:20:22,080 --> 01:20:23,360
MISSION TO MAKE DECISIONS FASTER

2242
01:20:23,360 --> 01:20:26,360
BECAUSE SOMETIMES THAT IS A HUGE

2243
01:20:26,360 --> 01:20:27,520
HURDLE EVEN THE TREATMENTS ARE

2244
01:20:27,520 --> 01:20:30,760
THERE PATIENTS STILL CAN'T GET

2245
01:20:30,760 --> 01:20:32,160
THEM.

2246
01:20:32,160 --> 01:20:33,640
>> THANK YOU SO MUCH FOR THOSE

2247
01:20:33,640 --> 01:20:34,160
COMMENTS.

2248
01:20:34,160 --> 01:20:39,280
I COULDN'T AGREE MORE, THE GOAL

2249
01:20:39,280 --> 01:20:41,960
OR THE THREE GOALS I OUTLINE IN

2250
01:20:41,960 --> 01:20:43,080
MANTRA OF MORE TREATMENT TO ALL

2251
01:20:43,080 --> 01:20:45,120
PEOPLE MORE QUICKLY, THAT IS

2252
01:20:45,120 --> 01:20:46,320
NCATS CAN'T DO THAT ALONE.

2253
01:20:46,320 --> 01:20:48,320
IT IS ABOUT THE ENTIRE

2254
01:20:48,320 --> 01:20:49,280
BIOMEDICAL SYSTEM COMING

2255
01:20:49,280 --> 01:20:50,840
TOGETHER AND THE PATIENT AND

2256
01:20:50,840 --> 01:20:52,680
PATIENT ADVOCACY GROUPS COMING

2257
01:20:52,680 --> 01:20:54,920
TOGETHER.

2258
01:20:54,920 --> 01:20:58,440
KRISTINA, I APPRECIATE YOUR THE

2259
01:20:58,440 --> 01:20:59,760
WAY YOU CAN ARTICULATE THESE

2260
01:20:59,760 --> 01:21:01,120
THINGS BECAUSE YOU ARE A RARE

2261
01:21:01,120 --> 01:21:02,680
MOM AND YOU SEE THESE FIRSTHAND

2262
01:21:02,680 --> 01:21:04,040
AND I THINK THAT IS VALUABLE TO

2263
01:21:04,040 --> 01:21:05,560
BRING INTO THESE DISCUSSIONS.

2264
01:21:05,560 --> 01:21:10,200
SO THAT WE CAN FIGHT THOSE --

2265
01:21:10,200 --> 01:21:11,440
THE OPERATIONAL PIECE OF THIS

2266
01:21:11,440 --> 01:21:12,520
ARE SO IMPORTANT AND CRITICAL

2267
01:21:12,520 --> 01:21:14,160
FOR US TO ADDRESS THE AT THE

2268
01:21:14,160 --> 01:21:14,920
SAME TIME TIME WE ADDRESS

2269
01:21:14,920 --> 01:21:17,320
SCIENCE.

2270
01:21:17,320 --> 01:21:17,480
I.

2271
01:21:17,480 --> 01:21:18,520
A A RARE KID I GUESS.

2272
01:21:18,520 --> 01:21:20,120
I HAVEN'T THOUGHT ABOUT THAT HOW

2273
01:21:20,120 --> 01:21:21,960
TO SAY THAT BUT HOW YOU PHRASE

2274
01:21:21,960 --> 01:21:26,320
IT AS BEING A RARE MOM, IS SO

2275
01:21:26,320 --> 01:21:26,920
COMPELLING.

2276
01:21:26,920 --> 01:21:28,080
MY MOM HAD A RARE DISEASE, IT

2277
01:21:28,080 --> 01:21:30,640
WASN'T A GENETIC DISEASE, IT WAS

2278
01:21:30,640 --> 01:21:32,040
MORE DIFFERENT KINDS OF CANCER

2279
01:21:32,040 --> 01:21:34,280
RELATED CONDITIONS BUT IT WAS A

2280
01:21:34,280 --> 01:21:35,440
RARE DISEASE NONETHELESS SO

2281
01:21:35,440 --> 01:21:37,320
THESE KINDS OF ISSUES ARE JUST

2282
01:21:37,320 --> 01:21:38,600
REALLY IMPORTANT TO ME AND THE

2283
01:21:38,600 --> 01:21:41,960
MORE WE BRING THESE PEOPLE AND

2284
01:21:41,960 --> 01:21:43,320
COMMUNITIES TOGETHER OUR VOICES

2285
01:21:43,320 --> 01:21:45,120
ARE GOING TO BE LOUDER AND

2286
01:21:45,120 --> 01:21:46,160
LOUDER.

2287
01:21:46,160 --> 01:21:49,320
AND WILL CREATE THAT SWELL OF

2288
01:21:49,320 --> 01:21:50,040
OPPORTUNITIES COMMUNITY SO THAT

2289
01:21:50,040 --> 01:21:51,560
WE CAN BE SUCCESSFUL FOR THESE

2290
01:21:51,560 --> 01:21:53,880
GOALS.

2291
01:21:53,880 --> 01:21:55,440
I THINK UNFORTUNATELY I HAVE TO

2292
01:21:55,440 --> 01:21:56,680
CUT OFF OUR DISCUSSION BECAUSE

2293
01:21:56,680 --> 01:21:58,160
WE DO HAVE OUR SPECIAL GUEST WHO

2294
01:21:58,160 --> 01:22:01,720
HAS ARRIVED.

2295
01:22:01,720 --> 01:22:03,560
TARA SCHWETZ, I HOPE YOU ARE

2296
01:22:03,560 --> 01:22:04,640
ABLE TO BE ON SCREEN HERE.

2297
01:22:04,640 --> 01:22:08,600
I WANT TO QUICKLY INTRODUCE TARA

2298
01:22:08,600 --> 01:22:08,800
TARA.

2299
01:22:08,800 --> 01:22:13,840
FOR MUCH OF 2021 LAST YEAR TARA

2300
01:22:13,840 --> 01:22:15,120
SCHWETZ HAS BEEN ON DETAIL TO

2301
01:22:15,120 --> 01:22:16,280
WHITE HOUSE OFFICE OF SCIENCE

2302
01:22:16,280 --> 01:22:17,480
TECHNOLOGY AND POLICY AS THE

2303
01:22:17,480 --> 01:22:18,920
ASSISTANT DIRECTOR FOR

2304
01:22:18,920 --> 01:22:20,600
BIOMEDICAL SCIENCE INITIATIVES.

2305
01:22:20,600 --> 01:22:22,280
IN THIS ROLE SHE'S LED THE

2306
01:22:22,280 --> 01:22:24,640
EFFORTS TO STAND UP THE ADVANCE

2307
01:22:24,640 --> 01:22:26,840
RESEARCH PROJECTS AGENCY HEALTH

2308
01:22:26,840 --> 01:22:29,320
FOR ARPA H AND SHE'S BEEN

2309
01:22:29,320 --> 01:22:30,520
WORKING WITHIN THE BIDEN

2310
01:22:30,520 --> 01:22:32,840
ADMINISTRATION TO PROPOSE ASH PA

2311
01:22:32,840 --> 01:22:34,880
H TO TACKLE SOME OF THESE ISSUES

2312
01:22:34,880 --> 01:22:35,920
THAT WE HAVE BEEN TALKING ABOUT

2313
01:22:35,920 --> 01:22:38,320
AS WELL.

2314
01:22:38,320 --> 01:22:41,320
NOW SHE IS IN HER NEW ROLE AS

2315
01:22:41,320 --> 01:22:43,480
ACTING PRINCIPAL DEPUTY DIRECTOR

2316
01:22:43,480 --> 01:22:45,440
AT THE NIH SO WE ARE HAPPY TO

2317
01:22:45,440 --> 01:22:49,680
HAVE TARA BACK AT THE NIH, BUT

2318
01:22:49,680 --> 01:22:50,840
HER CONNECTIONS WITH THIS

2319
01:22:50,840 --> 01:22:54,320
PARTICULAR ARPA H OSTP LIAISON

2320
01:22:54,320 --> 01:22:57,640
AND DETAILING HAS -- I THINK

2321
01:22:57,640 --> 01:22:59,760
WILL PROVE VERY BENEFICIAL AS WE

2322
01:22:59,760 --> 01:23:01,640
GO FORWARD NO MATTER WHAT THAT

2323
01:23:01,640 --> 01:23:02,280
MIGHT LOOK LIKE.

2324
01:23:02,280 --> 01:23:04,280
SO TARA, I WILL TURN IT TO YOU

2325
01:23:04,280 --> 01:23:06,160
AND HAVE YOU GIVE US A STATUS

2326
01:23:06,160 --> 01:23:07,840
UPDATE ON WHAT YOU KNOW ABOUT

2327
01:23:07,840 --> 01:23:08,320
ARPA H.

2328
01:23:08,320 --> 01:23:09,120
THANK YOU SO MUCH FOR JOINING

2329
01:23:09,120 --> 01:23:12,920
US.

2330
01:23:12,920 --> 01:23:14,000
>> THAW FOR HAVING ME.

2331
01:23:14,000 --> 01:23:15,040
I HOPE YOU CAN HEAR ME.

2332
01:23:15,040 --> 01:23:17,320
I'M GOING TO PREFACE THIS I HAVE

2333
01:23:17,320 --> 01:23:18,960
BEEN HAVING INTERNET TROUBLE ALL

2334
01:23:18,960 --> 01:23:21,240
DAY ON AND OFF SO I HAVE BACK

2335
01:23:21,240 --> 01:23:23,880
UPON BACK UP HERE IF I NEED TO

2336
01:23:23,880 --> 01:23:26,320
SWITCH NETWORKS AND COMPUTERS

2337
01:23:26,320 --> 01:23:28,240
AND EVERYTHING ELSE.

2338
01:23:28,240 --> 01:23:30,160
I'M GLAD I WAS ABLE TO GET ON

2339
01:23:30,160 --> 01:23:31,280
COUPLE OF MINUTES EARLY TO HEAR

2340
01:23:31,280 --> 01:23:33,160
THE END OF THAT DISCUSSION

2341
01:23:33,160 --> 01:23:35,920
BECAUSE I THINK THIS TIES SO

2342
01:23:35,920 --> 01:23:37,160
NICELY WITH WHAT SOME OF THE

2343
01:23:37,160 --> 01:23:39,640
ROLES THAT ARPA H CAN PLAY

2344
01:23:39,640 --> 01:23:47,000
PARTICULARLY TO THE LAST

2345
01:23:47,000 --> 01:23:48,520
COMMENTS BECAUSE I HOPE ARPA H

2346
01:23:48,520 --> 01:23:51,120
IS A FACILITATOR BETWEEN THE

2347
01:23:51,120 --> 01:23:52,080
RESEARCH EFFORTS COMING OUT

2348
01:23:52,080 --> 01:23:53,800
WORKING WITH FDA AND CMS MORE

2349
01:23:53,800 --> 01:23:56,680
CLOSELY, THAT WILL BE A CRITICAL

2350
01:23:56,680 --> 01:24:00,360
ROLE:  SO WE CAN HELP ADVANCE

2351
01:24:00,360 --> 01:24:05,120
THAT AS ARPA H HOPEFULLY GETS

2352
01:24:05,120 --> 01:24:09,120
PULLED TOGETHER AND IS ABLE GET

2353
01:24:09,120 --> 01:24:09,840
LAUNCHED.

2354
01:24:09,840 --> 01:24:11,560
I KNOW Y'ALL HEARD ABOUT ARPA H

2355
01:24:11,560 --> 01:24:13,520
BEFORE AND CLEARLY BY DISCUSSION

2356
01:24:13,520 --> 01:24:14,840
THIS IS NOTHING COMPLETELY NEW

2357
01:24:14,840 --> 01:24:16,600
FOR ALL OF YOU BUT JUST TO SORT

2358
01:24:16,600 --> 01:24:18,640
OF TAKE A STEP BACK AND ENSURE

2359
01:24:18,640 --> 01:24:20,160
EVERYONE IS ON THE SAME PAGE, I

2360
01:24:20,160 --> 01:24:23,360
WANT TO REMIND FOLKS ARPA H IS

2361
01:24:23,360 --> 01:24:25,280
ADVANCE RESEARCH PRODUCT AGENCY

2362
01:24:25,280 --> 01:24:26,000
FOR HEALTH.

2363
01:24:26,000 --> 01:24:29,920
THIS IS BEING PROPOSED AS A NEW

2364
01:24:29,920 --> 01:24:31,720
ENTITY THAT WILL EQUITABLY

2365
01:24:31,720 --> 01:24:33,880
BENEFIT HEALTH OF ALL AMERICANS

2366
01:24:33,880 --> 01:24:36,120
BY HELPING CATALYZE FULL BREAK

2367
01:24:36,120 --> 01:24:37,320
THROUGH, THE SHORT AND SIMPLE OF

2368
01:24:37,320 --> 01:24:38,240
IT.

2369
01:24:38,240 --> 01:24:43,680
IF YOU CAN GO TO THE NEXT SLIDE.

2370
01:24:43,680 --> 01:24:45,600
THINKING ABOUT WHAT COULD BE

2371
01:24:45,600 --> 01:24:48,720
DONE AND WHAT HAS BEEN DONE OVER

2372
01:24:48,720 --> 01:24:50,320
THE LAST SEVERAL DECADES.

2373
01:24:50,320 --> 01:24:53,120
WE KNOW SCIENCE HAS DONE AMAZING

2374
01:24:53,120 --> 01:24:53,520
THINGS.

2375
01:24:53,520 --> 01:24:56,720
WE ARE AT THIS REALLY

2376
01:24:56,720 --> 01:24:58,680
UNPRECEDENTED MOMENT OF PROGRESS

2377
01:24:58,680 --> 01:25:00,200
PARTICULARLY AS WE ARE STILL

2378
01:25:00,200 --> 01:25:00,800
MISPANDEMIC BUT WE HAVE BEEN

2379
01:25:00,800 --> 01:25:03,440
ABLE THE SEE SOME AMAZING

2380
01:25:03,440 --> 01:25:06,680
SCIENTIFIC WORK COME OUT OF WORK

2381
01:25:06,680 --> 01:25:12,360
DONE AND SUPPORTED BY NCATS BUT

2382
01:25:12,360 --> 01:25:13,640
IT TAKES CAUSES TAKE A STEP BACK

2383
01:25:13,640 --> 01:25:16,320
AND SAY WHAT MORE CAN WE DO TO

2384
01:25:16,320 --> 01:25:17,520
SPEED REVOLUTIONIZE AND

2385
01:25:17,520 --> 01:25:19,280
TRANSFORM MEDICINE AND IMPROVE

2386
01:25:19,280 --> 01:25:22,920
THE HEALTH OF ALL AMERICANS.

2387
01:25:22,920 --> 01:25:26,720
SO IF WE IMAGINE FOR -- FOR

2388
01:25:26,720 --> 01:25:29,160
INSTANCE, IF WE CAN PROGRAM

2389
01:25:29,160 --> 01:25:32,400
MRNA TO PRE-VACCINATE US

2390
01:25:32,400 --> 01:25:33,880
AGAINST 50 MOST COMMON MUTATIONS

2391
01:25:33,880 --> 01:25:37,960
TA DRIVE CANCER, THIS GIVES OUR

2392
01:25:37,960 --> 01:25:40,320
BODIES A CHANCE TO TARGET AND

2393
01:25:40,320 --> 01:25:41,320
ELIMINATE BEFORE THEY CAN CREATE

2394
01:25:41,320 --> 01:25:43,480
A TUMOR, WHAT IF WE COULD

2395
01:25:43,480 --> 01:25:45,520
DEVELOP DRUGS THAT HAVE PRECISE

2396
01:25:45,520 --> 01:25:47,320
MOLECULAR ZIP CODES THAT WOULD

2397
01:25:47,320 --> 01:25:49,360
ALLOW FOR UNPRECEDENTED

2398
01:25:49,360 --> 01:25:51,720
TARGETING ACROSS THE BLOOD BRAIN

2399
01:25:51,720 --> 01:25:54,360
BARRIER TO SPECIFIC CELLS IN OUR

2400
01:25:54,360 --> 01:25:55,840
BODY, WITHOUT ANY UNTOWARD SIDE

2401
01:25:55,840 --> 01:25:57,520
EFFECTS AND THESE ARE JUST

2402
01:25:57,520 --> 01:25:59,720
COUPLE OF EXAMPLES AND THERE ARE

2403
01:25:59,720 --> 01:26:02,080
OTHERS ON THE SLIDE AS WELL OF

2404
01:26:02,080 --> 01:26:05,080
THE POTENTIAL CAPABILITIES AND

2405
01:26:05,080 --> 01:26:06,920
PLATFORMS THAT COULD BE POSSIBLE

2406
01:26:06,920 --> 01:26:08,680
IF WE COULD HARNESS THE BEST

2407
01:26:08,680 --> 01:26:10,760
IDEAS AT THE RIGHT TIME WITH THE

2408
01:26:10,760 --> 01:26:14,920
RIGHT AMOUNT OF RESOURCES.

2409
01:26:14,920 --> 01:26:16,520
I'M SURE Y'ALL HAVE BETTER IDEAS

2410
01:26:16,520 --> 01:26:18,680
YOU ARE HIKING AS YOU LOOK AT

2411
01:26:18,680 --> 01:26:19,280
THIS SLIDE.

2412
01:26:19,280 --> 01:26:22,040
I THINK THAT FOR ME WHAT THAT

2413
01:26:22,040 --> 01:26:27,040
SIGNAL IS POTENTIAL FOR

2414
01:26:27,040 --> 01:26:28,560
OPPORTUNITIES HERE THAT WE HAVE

2415
01:26:28,560 --> 01:26:31,800
WITH ARPA H IS EVEN MORE

2416
01:26:31,800 --> 01:26:33,240
EXCITING AND REALLY TREMENDOUS.

2417
01:26:33,240 --> 01:26:37,440
SO WE MOVE TO THE NEXT SLIDE.

2418
01:26:37,440 --> 01:26:41,320
I JUST WANT TO QUICKLY GO OVER

2419
01:26:41,320 --> 01:26:42,880
WHAT POTENTIAL VERSION OF THE

2420
01:26:42,880 --> 01:26:45,520
MISSION COULD READ BECAUSE OF

2421
01:26:45,520 --> 01:26:47,800
COURSE AT MOMENT ARPA H IS STILL

2422
01:26:47,800 --> 01:26:50,320
JUST A PROPOSAL.

2423
01:26:50,320 --> 01:26:55,160
BUT WHAT WE HAVE HERE IS THAT

2424
01:26:55,160 --> 01:26:56,360
AID COULD BENEFIT THE HEALTH OF

2425
01:26:56,360 --> 01:26:57,680
ALL AMERICANS BY UTILIZING

2426
01:26:57,680 --> 01:26:59,360
HEALTH BREAK THROUGHS NOT

2427
01:26:59,360 --> 01:27:00,720
READILY ACCOMPLISHED THROUGH

2428
01:27:00,720 --> 01:27:03,080
TRADITIONAL RESEARCH OR

2429
01:27:03,080 --> 01:27:03,520
COMMERCIAL ACTIVITY.

2430
01:27:03,520 --> 01:27:06,240
TO ME THE LAST POINT IS REALLY

2431
01:27:06,240 --> 01:27:08,120
KEY BECAUSE WHAT WE ARE TALKING

2432
01:27:08,120 --> 01:27:10,360
ABOUT IS DOING THINGS THAT CAN'T

2433
01:27:10,360 --> 01:27:12,040
BE DONE CURRENTLY, THAT ARE

2434
01:27:12,040 --> 01:27:13,320
REALLY INCREDIBLY DIFFICULT TO

2435
01:27:13,320 --> 01:27:15,040
DO.

2436
01:27:15,040 --> 01:27:17,200
THAT IS THE SPACE THAT ARPA H

2437
01:27:17,200 --> 01:27:21,320
WANTS TO LIVE IN.

2438
01:27:21,320 --> 01:27:23,680
ADVANCING THIS MISSION AND THE

2439
01:27:23,680 --> 01:27:26,120
IDEAS MENTIONED PREVIOUSLY, IS

2440
01:27:26,120 --> 01:27:28,680
GOING TO REQUIRE A NOVEL

2441
01:27:28,680 --> 01:27:30,480
APPROACH TO MORE SUPPORTING

2442
01:27:30,480 --> 01:27:32,920
BROAD BIOMEDICAL RESEARCH.

2443
01:27:32,920 --> 01:27:38,840
AND THE IDEA WITH ARPA H IS TO

2444
01:27:38,840 --> 01:27:39,320
LEVERAGE --

2445
01:27:39,320 --> 01:27:41,520
>> WE HAVE LOST YOUR AUDIO.

2446
01:27:41,520 --> 01:27:43,440
HOPEFULLY YOU CAN STILL HEAR US?

2447
01:27:43,440 --> 01:27:44,640
>> I CAN.

2448
01:27:44,640 --> 01:27:46,760
>> I HEAR TARA JUST FINE.

2449
01:27:46,760 --> 01:27:48,200
HAVE OTHERS?

2450
01:27:48,200 --> 01:27:49,000
>> SAME HERE.

2451
01:27:49,000 --> 01:27:51,400
>> I'M HEARING HER FINE AS WELL.

2452
01:27:51,400 --> 01:27:52,880
>> WE CAN HEAR HER.

2453
01:27:52,880 --> 01:27:53,280
>> OKAY.

2454
01:27:53,280 --> 01:27:54,160
GOOD.

2455
01:27:54,160 --> 01:27:57,640
I WAS WORRIED FOR A SECOND.

2456
01:27:57,640 --> 01:27:59,760
I HAVE OTHER DEVICES TO SWITCH

2457
01:27:59,760 --> 01:28:05,760
TO IF NEEDED.

2458
01:28:05,760 --> 01:28:07,800
HOPEFULLY AUDIO GETS CORRECTED

2459
01:28:07,800 --> 01:28:09,720
ON YOUR END AND OTHERS CAN STILL

2460
01:28:09,720 --> 01:28:11,120
HEAR ME.

2461
01:28:11,120 --> 01:28:15,320
TO GO BACK TO THIS APPROACH,

2462
01:28:15,320 --> 01:28:17,240
THAT ARPA H IS GOING TO TAKE,

2463
01:28:17,240 --> 01:28:19,880
LEVERAGING WHAT WAS PIONEERED AT

2464
01:28:19,880 --> 01:28:23,520
DARPA, IT'S UTILIZED THERE FOR

2465
01:28:23,520 --> 01:28:26,920
60 PLUS YEARS, AND HAS ALSO BEEN

2466
01:28:26,920 --> 01:28:29,040
APPLIED IN OTHER AREAS OF R&D

2467
01:28:29,040 --> 01:28:30,200
MORE RECENTLY.

2468
01:28:30,200 --> 01:28:33,960
IF YOU THINK ABOUT ARPA E, AND

2469
01:28:33,960 --> 01:28:37,520
EVEN BRTA, AND WE REALLY WANT TO

2470
01:28:37,520 --> 01:28:39,640
EMBRACE THIS APPROACH FOR

2471
01:28:39,640 --> 01:28:43,760
BIOMEDICAL AND HEALTH RESEARCH.

2472
01:28:43,760 --> 01:28:46,000
WE PROPOSE TO CREATE THIS

2473
01:28:46,000 --> 01:28:48,520
DISTINCT ENTITY WITHIN NIH

2474
01:28:48,520 --> 01:28:50,440
THAT'S HAVE AUTONOMY AND

2475
01:28:50,440 --> 01:28:51,760
INDEPENDENCE RESOURCES AND

2476
01:28:51,760 --> 01:28:53,120
AUTHORITIES TO TACKLE SOME OF

2477
01:28:53,120 --> 01:28:54,600
THESE BIG CHALLENGES FACING

2478
01:28:54,600 --> 01:29:01,960
HUMAN HEALTH.

2479
01:29:01,960 --> 01:29:03,560
IN THE NEXT SLIDE WE TALK ABOUT

2480
01:29:03,560 --> 01:29:04,760
THIS ARPA MODEL.

2481
01:29:04,760 --> 01:29:06,680
FOR ANYONE WHO MAY BE LESS

2482
01:29:06,680 --> 01:29:09,600
FAMILIAR JUST AGAIN TO LEVEL A

2483
01:29:09,600 --> 01:29:13,840
LITTLE, THE MODEL EMBRACES A

2484
01:29:13,840 --> 01:29:16,000
PROGRAM MANAGER CENTRIC

2485
01:29:16,000 --> 01:29:17,440
MENTALITY, IT PROMOTES ACTIVE

2486
01:29:17,440 --> 01:29:18,760
PROJECT MANAGEMENT AND

2487
01:29:18,760 --> 01:29:19,240
ACCOUNTABILITY THROUGH

2488
01:29:19,240 --> 01:29:22,920
QUANTIFIABLE METRICS AN STAGE

2489
01:29:22,920 --> 01:29:23,440
GATING.

2490
01:29:23,440 --> 01:29:25,680
IT APPROACH THE ORGANIZATION

2491
01:29:25,680 --> 01:29:29,880
THROUGH A LENS OF BEING LEAN AND

2492
01:29:29,880 --> 01:29:31,640
MINIMUMMABLE BUT BUILDS IN A

2493
01:29:31,640 --> 01:29:37,000
FAIR AMOUNT OF AUTONOMY AND

2494
01:29:37,000 --> 01:29:37,640
ACCOUNTABILITY.

2495
01:29:37,640 --> 01:29:41,120
IT FOCUSES ON MISSION DRIVEN

2496
01:29:41,120 --> 01:29:43,240
RATHER THAN REQUIREMENT OR CAST

2497
01:29:43,240 --> 01:29:45,360
DRIVEN -- TASK DRIVEN RESEARCH.

2498
01:29:45,360 --> 01:29:48,320
MENT THAT WHICH IS BOLD AND

2499
01:29:48,320 --> 01:29:51,440
RISKY BUT COULD OFFER REALLY

2500
01:29:51,440 --> 01:29:52,400
HIGH RETURN.

2501
01:29:52,400 --> 01:29:54,280
T THAT ADHERES TO URGENT TIME

2502
01:29:54,280 --> 01:29:56,000
BOUND PRINCIPLES THAT ARE

2503
01:29:56,000 --> 01:29:58,560
APPLIED NOT JUST TO THE PROGRAM

2504
01:29:58,560 --> 01:30:01,080
-- BUT ALSO TO THE STAFF TENURE.

2505
01:30:01,080 --> 01:30:03,080
IN REFERENCE TO SORT OF THIS

2506
01:30:03,080 --> 01:30:05,320
HIGH RISK HIGH REWARD APPROACH I

2507
01:30:05,320 --> 01:30:07,080
LIKE TO GIVE THE ANALOGY THAT

2508
01:30:07,080 --> 01:30:10,040
WHAT WE WANT TO DO WITH ARPA H

2509
01:30:10,040 --> 01:30:14,320
IS ON SOME LEVEL, HITTING -- IT

2510
01:30:14,320 --> 01:30:16,520
IS LIKE THROWING A DART IN A

2511
01:30:16,520 --> 01:30:17,120
DARK ROOM.

2512
01:30:17,120 --> 01:30:20,360
IF YOU HIT A DARK DART BOARD, ON

2513
01:30:20,360 --> 01:30:22,680
THE BULLS EYE IT IS AMAZING.

2514
01:30:22,680 --> 01:30:24,920
AND IF YOU DON'T YOU LEARN THAT

2515
01:30:24,920 --> 01:30:26,920
IT IS NOT IN THAT LOCATION AND

2516
01:30:26,920 --> 01:30:30,320
NOW YOU CAN AIM SOMEWHERE ELSE.

2517
01:30:30,320 --> 01:30:31,840
BUT OBVIOUSLY BUILDING OFF AND

2518
01:30:31,840 --> 01:30:33,920
LEARNING FROM WHAT YOU ARE DOING

2519
01:30:33,920 --> 01:30:36,480
BUT HAVING THE POTENTIAL TO HAVE

2520
01:30:36,480 --> 01:30:41,440
A REALLY HIGH IMPACT SO IF WE

2521
01:30:41,440 --> 01:30:45,280
MOVE TO THE NEXT SLIDE.

2522
01:30:45,280 --> 01:30:49,560
TO ENUMERATE THE GOALS OF ARPA

2523
01:30:49,560 --> 01:30:52,160
H, POTENTIAL GOALS OF ARPA H.

2524
01:30:52,160 --> 01:30:53,760
THEY ARE HERE SUPPORTING

2525
01:30:53,760 --> 01:30:55,360
TRANSFORMATIVE HIGH RISK HIGH

2526
01:30:55,360 --> 01:30:57,480
REWARD RESEARCH OF COURSE BUT

2527
01:30:57,480 --> 01:31:01,400
DOING SO BY EMBRACING A SENSE OF

2528
01:31:01,400 --> 01:31:03,000
URGENCY AND SPEEDING THE

2529
01:31:03,000 --> 01:31:05,000
APPLICATION IMPLEMENTATION OF

2530
01:31:05,000 --> 01:31:07,000
BREAK THROUGHS AT VARIETY OF

2531
01:31:07,000 --> 01:31:08,040
DIFFERENT LEVELS.

2532
01:31:08,040 --> 01:31:09,920
SO WE SAY FROM THE MOLECULAR TO

2533
01:31:09,920 --> 01:31:12,400
THE SOCIETAL.

2534
01:31:12,400 --> 01:31:15,160
AND RECOGNIZING THAT IS PRETTY

2535
01:31:15,160 --> 01:31:16,520
BROAD BUT DOING SO IN A WAY THEY

2536
01:31:16,520 --> 01:31:18,560
SERVE ALL PEOPLE.

2537
01:31:18,560 --> 01:31:21,720
TO BUILD CAPABILITIES AND

2538
01:31:21,720 --> 01:31:23,880
PLATFORMS THAT ARE BROADLY

2539
01:31:23,880 --> 01:31:25,560
APPLICABLE ACROSS A WIDE RANGE

2540
01:31:25,560 --> 01:31:27,800
OF DISEASE AND CONDITIONS.

2541
01:31:27,800 --> 01:31:31,400
TO REVOLUTIONIZE HOW WE PREVENT

2542
01:31:31,400 --> 01:31:32,360
DETECT TREAT CURE THEM.

2543
01:31:32,360 --> 01:31:36,360
WE WANT TO FOCUS ON CONVERTING

2544
01:31:36,360 --> 01:31:38,800
USE DRIVEN IDEAS SO THOSE IDEAS

2545
01:31:38,800 --> 01:31:41,160
WITH DIRECT APPLICATION INTO THE

2546
01:31:41,160 --> 01:31:42,480
SOLUTION FOR PATIENTS REALLY

2547
01:31:42,480 --> 01:31:43,600
QUICKLY.

2548
01:31:43,600 --> 01:31:46,800
AND THEN HELP OVERCOME MARKET

2549
01:31:46,800 --> 01:31:50,880
FAILURES THROUGH CREATIVE

2550
01:31:50,880 --> 01:31:52,320
SOLUTIONS AND DERISKING.

2551
01:31:52,320 --> 01:31:54,120
THERE ARE AREAS RIPE FOR

2552
01:31:54,120 --> 01:31:55,120
TRANSFORMATION IF STIMULATED

2553
01:31:55,120 --> 01:31:57,280
THEM THROUGH THE RIGHT SUPPORT

2554
01:31:57,280 --> 01:31:59,320
AND COLLABORATION.

2555
01:31:59,320 --> 01:32:05,880
IF WE MOVE TO THE NEXT SLIDE.

2556
01:32:05,880 --> 01:32:07,320
THE GUIDING PRINCIPLES THAT

2557
01:32:07,320 --> 01:32:09,280
DRIVE ARPA H ECHO ELEMENTS OF

2558
01:32:09,280 --> 01:32:12,960
THE ARPA MODEL.

2559
01:32:12,960 --> 01:32:15,160
ARPA H IS CENTERED AROUND AND

2560
01:32:15,160 --> 01:32:16,880
SHOWING THIS RISK TOLERANCE OR

2561
01:32:16,880 --> 01:32:21,480
RISK ACCEPTANCE, AND INSTILLING

2562
01:32:21,480 --> 01:32:24,480
KEY FOUNDATIONAL VALUES THAT ARE

2563
01:32:24,480 --> 01:32:27,400
INHERENT IN THE ARPA MODEL.

2564
01:32:27,400 --> 01:32:29,440
BUT IN ORDER TO DO THAT WE

2565
01:32:29,440 --> 01:32:31,160
RECOGNIZE CULTURE IS KEY TO ARPA

2566
01:32:31,160 --> 01:32:34,440
H SUCCESS.

2567
01:32:34,440 --> 01:32:36,040
THAT IS SOMETHING NCATS WORKED

2568
01:32:36,040 --> 01:32:37,680
HARD TO BUILD AND DEVELOP OVER

2569
01:32:37,680 --> 01:32:42,680
ITS TEN PLUS YEARS NOW HISTORY.

2570
01:32:42,680 --> 01:32:45,720
AND THINKING ABOUT WHERE ARPA H

2571
01:32:45,720 --> 01:32:48,520
SHOULD LIVE, THE ADMINISTRATION

2572
01:32:48,520 --> 01:32:50,440
SUPPORTS ARPA H, HE PROPOSES A

2573
01:32:50,440 --> 01:32:53,120
COME PENT OF NIH.

2574
01:32:53,120 --> 01:32:55,720
AND LINKED TO NIH REALLY DRAW ON

2575
01:32:55,720 --> 01:32:58,320
THE VAST KNOWLEDGE EXPERTISE AND

2576
01:32:58,320 --> 01:32:59,480
INFRASTRUCTURE THAT CURRENTLY

2577
01:32:59,480 --> 01:33:03,600
EXISTS HERE AT NIH.

2578
01:33:03,600 --> 01:33:06,040
INCLUDING INSTITUTES LIKE NCATS

2579
01:33:06,040 --> 01:33:07,360
AND THINKING CONNECTIONS AND

2580
01:33:07,360 --> 01:33:08,720
COLLABORATIONS AND SYNERGIES

2581
01:33:08,720 --> 01:33:09,920
THAT WE CAN BUILD THERE.

2582
01:33:09,920 --> 01:33:12,520
BUT RECOGNIZING THAT IT DOES

2583
01:33:12,520 --> 01:33:14,400
NEED TO BE DISTINCT AND HAVE ITS

2584
01:33:14,400 --> 01:33:16,440
OWN CULTURE AND ORGANIZATION

2585
01:33:16,440 --> 01:33:20,560
AUTONOMY.

2586
01:33:20,560 --> 01:33:23,040
IN DOING SO ARPA H IS GOING TO

2587
01:33:23,040 --> 01:33:26,240
SEEK THE BRING ON THE MOST

2588
01:33:26,240 --> 01:33:28,160
INNOVATIVE PEOPLE WITH THE MOST

2589
01:33:28,160 --> 01:33:31,200
NOVEL IDEAS THAT WILL FORM

2590
01:33:31,200 --> 01:33:32,320
ROBUSTLY DIVERSE AND

2591
01:33:32,320 --> 01:33:34,560
COLLABORATIVE TEAM.

2592
01:33:34,560 --> 01:33:38,000
AND EQUITY IS GOING TO BE

2593
01:33:38,000 --> 01:33:39,520
ESSENTIAL AND GOING TO BE

2594
01:33:39,520 --> 01:33:41,240
CONSIDERED ESSENTIAL ELEMENT OF

2595
01:33:41,240 --> 01:33:44,960
ARPA H AND KEY IN ITS INTERNAL

2596
01:33:44,960 --> 01:33:47,640
PRACTICES LIKE HIRING AND IN THE

2597
01:33:47,640 --> 01:33:49,440
PROJECTS AND PROGRAMS IT

2598
01:33:49,440 --> 01:33:51,320
SUPPORTS, I LOOK AT THIS IN SORT

2599
01:33:51,320 --> 01:33:52,920
OF THREE WAYS.

2600
01:33:52,920 --> 01:33:54,680
RIGHT?

2601
01:33:54,680 --> 01:33:56,560
THINKING ABOUT ROBUST EQUITY IN

2602
01:33:56,560 --> 01:33:58,600
THE PEOPLE THAT HIRE, THE

2603
01:33:58,600 --> 01:34:00,600
PROGRAMS THAT SUPPORT, AND THE

2604
01:34:00,600 --> 01:34:09,640
PERFORMERS IT MAKES AWARDS TO.

2605
01:34:09,640 --> 01:34:10,280
CONTINUING WHICH IS DOES AROUND

2606
01:34:10,280 --> 01:34:15,840
PEOPLE, THE DIRECTOR OF ARPA H

2607
01:34:15,840 --> 01:34:17,200
AS WELL AS PROGRAM MANAGERS ARE

2608
01:34:17,200 --> 01:34:18,280
INTENDED TO BE TERM LIMITED AND

2609
01:34:18,280 --> 01:34:21,240
NOT A 20 YEAR TERM, MUCH SHORTER

2610
01:34:21,240 --> 01:34:21,920
TERMS.

2611
01:34:21,920 --> 01:34:23,360
THINKING IN THE LIKE THREE TO

2612
01:34:23,360 --> 01:34:27,920
FIVE YEAR RANGE.

2613
01:34:27,920 --> 01:34:29,400
THIS FIRST DIRECTOR, THEY ARE

2614
01:34:29,400 --> 01:34:31,400
GOING TO SET THE STAGE FOR SO

2615
01:34:31,400 --> 01:34:33,320
MANY YEARS TO COME AND IT IS

2616
01:34:33,320 --> 01:34:35,240
GOING TO BE REALLY CRITICAL FOR

2617
01:34:35,240 --> 01:34:38,120
US TO FIND THE RIGHT LEADER,

2618
01:34:38,120 --> 01:34:39,800
THAT'S GOING TO EXCEL

2619
01:34:39,800 --> 01:34:44,240
TECHNICALLY AND AS A LEADER.

2620
01:34:44,240 --> 01:34:49,520
IT WILL ALSO BE A REALLY FLAT

2621
01:34:49,520 --> 01:34:52,400
DYNAMIC ORGANIZATION BUILT

2622
01:34:52,400 --> 01:34:55,680
NIMBLE AND OPERATIONALIZING

2623
01:34:55,680 --> 01:34:56,400
SCIENTIFIC PORTFOLIO.

2624
01:34:56,400 --> 01:34:58,920
AND BUSINESS PROCESSES.

2625
01:34:58,920 --> 01:35:00,400
AGAIN WE TALK ABOUT THAT SENSE

2626
01:35:00,400 --> 01:35:03,280
OF URGENCY AND OPERATING UNDER

2627
01:35:03,280 --> 01:35:06,920
TIME BOUND PRINCIPLES.

2628
01:35:06,920 --> 01:35:08,320
WHAT WE MEAN BY THAT IN ADDITION

2629
01:35:08,320 --> 01:35:09,920
TO TERM LIMITS WHAT I ALWAYS

2630
01:35:09,920 --> 01:35:12,800
HEAR WHAT I HAVE HEARD MANY,

2631
01:35:12,800 --> 01:35:15,040
MANY TIMES FROM THE DRPA FOLKS I

2632
01:35:15,040 --> 01:35:16,680
HAVE SPOKEN WITH IS WHEN THEY

2633
01:35:16,680 --> 01:35:18,520
COME ON BOARD, THEY GET THEIR

2634
01:35:18,520 --> 01:35:20,600
BADGE AND THEIR BADGE HAS AN

2635
01:35:20,600 --> 01:35:22,680
EXPIRATION DATE ON IT AND THAT'S

2636
01:35:22,680 --> 01:35:24,320
THEIR TICKING TIME CLOCK.

2637
01:35:24,320 --> 01:35:25,960
THEY LOOK AT THAT EVERY DAY WHEN

2638
01:35:25,960 --> 01:35:28,320
THEY PLUG TO COMPUTER OR WHEN WE

2639
01:35:28,320 --> 01:35:29,680
WERE GOING BACK TO THE OFFICE

2640
01:35:29,680 --> 01:35:31,000
AND THEY SCANNED IT TO GET IN

2641
01:35:31,000 --> 01:35:32,960
THE BUILDING OR THROUGH THE GATE

2642
01:35:32,960 --> 01:35:33,560
OR WHATEVER.

2643
01:35:33,560 --> 01:35:36,760
IT WAS A CONSTANT REMINDER OF

2644
01:35:36,760 --> 01:35:38,760
WHAT THEY WANTED TO ACHIEVE OVER

2645
01:35:38,760 --> 01:35:43,120
THAT TIME PERIOD.

2646
01:35:43,120 --> 01:35:48,320
I THINK THAT THAT IS JUST A

2647
01:35:48,320 --> 01:35:49,680
REALLY NICE MANIFESTATION OF

2648
01:35:49,680 --> 01:35:53,160
LIKE THAT CULTURAL ASPECT.

2649
01:35:53,160 --> 01:35:58,360
I WILL ALSO MENTION IN TERMS OF

2650
01:35:58,360 --> 01:35:59,440
THINKING THROUGH TIME BOUND

2651
01:35:59,440 --> 01:35:59,880
PRINCIPLES.

2652
01:35:59,880 --> 01:36:05,560
IT IS GOING TO BE GOING TO

2653
01:36:05,560 --> 01:36:07,600
OPERATE WITH UTILIZING DIFFERENT

2654
01:36:07,600 --> 01:36:09,920
PROCESSES.

2655
01:36:09,920 --> 01:36:13,520
FROM THE REST OF NIH, IT LIKELY

2656
01:36:13,520 --> 01:36:17,760
WILL NOT BE ISSUING GRANTS BUT

2657
01:36:17,760 --> 01:36:21,240
MORE TAKE AGO APPROPRIATE OF

2658
01:36:21,240 --> 01:36:22,600
CONTRACTS AILINGOR AND

2659
01:36:22,600 --> 01:36:23,400
TRANSACTION AND CHALLENGES,

2660
01:36:23,400 --> 01:36:24,640
THINGS YOU ARE FAMILIAR WITH BUT

2661
01:36:24,640 --> 01:36:28,880
WANTED TO MENTION THAT.

2662
01:36:28,880 --> 01:36:30,120
WITHOUT DWELL ON THIS SLIDE TOO

2663
01:36:30,120 --> 01:36:32,720
MUCH LONGER, I JUST WANT TO

2664
01:36:32,720 --> 01:36:33,960
REITERATE THE IMPORTANCE OF OPEN

2665
01:36:33,960 --> 01:36:36,360
AND TRANSPARENT.

2666
01:36:36,360 --> 01:36:38,120
ABOUT PROsS AND APPROACHES AS

2667
01:36:38,120 --> 01:36:39,240
IT DEVELOPS THEM.

2668
01:36:39,240 --> 01:36:44,120
AND IMPORTANTLY, ENGAGING

2669
01:36:44,120 --> 01:36:45,560
STAKEHOLDERS ACROSS A WIDE RANGE

2670
01:36:45,560 --> 01:36:50,200
OF SECTORS AND DISCIPLINES EARLY

2671
01:36:50,200 --> 01:36:50,640
AND OFTEN.

2672
01:36:50,640 --> 01:36:52,920
IF WE ARE DEVELOPING THIS AS WE

2673
01:36:52,920 --> 01:36:56,000
TALK ABOUT IT WITH A FOCUS ON

2674
01:36:56,000 --> 01:36:59,280
USE DRIVEN RESEARCH, WE WANT TO

2675
01:36:59,280 --> 01:37:01,800
BE COGNIZANT ABOUT THE FACT THAT

2676
01:37:01,800 --> 01:37:03,920
THOSE END USERS SHOULD BE

2677
01:37:03,920 --> 01:37:06,720
INVOLVED AND AT THE TABLE FROM

2678
01:37:06,720 --> 01:37:08,920
THE BEGINNING STAGES OF

2679
01:37:08,920 --> 01:37:09,640
DEVELOPING A PROGRAM.

2680
01:37:09,640 --> 01:37:12,400
AND CONSULTING THROUGH THE

2681
01:37:12,400 --> 01:37:13,520
PROCESS.

2682
01:37:13,520 --> 01:37:17,800
AND TO MISQUOTE I GUESS, THE --

2683
01:37:17,800 --> 01:37:20,560
I GUESS OFTEN USED FIELD OF

2684
01:37:20,560 --> 01:37:23,960
DREAMS ANALOGY, IF YOU BUILD IT

2685
01:37:23,960 --> 01:37:27,160
THEY WILL COME, WHAT WE DON'T

2686
01:37:27,160 --> 01:37:29,160
WANT TO DO IS BUILD IT, HAVE

2687
01:37:29,160 --> 01:37:32,120
THEM COME AND THEN WHY ON EARTH

2688
01:37:32,120 --> 01:37:33,520
DID YOU BUILD A BASEBALL PEELED

2689
01:37:33,520 --> 01:37:35,760
IN THE MIDDLE OF A CORN FIELD?

2690
01:37:35,760 --> 01:37:37,520
AND SOMETIMES THAT WORKS AND IT

2691
01:37:37,520 --> 01:37:42,000
IS AMAZING BUT OTHER TIMES I ASK

2692
01:37:42,000 --> 01:37:43,720
WHY DIDN'T YOU BUILD A SOCCER

2693
01:37:43,720 --> 01:37:45,680
FIELD, THAT'S WHAT WE WOULD HAVE

2694
01:37:45,680 --> 01:37:46,320
WANTED.

2695
01:37:46,320 --> 01:37:48,200
SOMETHING COMPLETELY DIFFERENT.

2696
01:37:48,200 --> 01:37:51,920
NOT EVEN A FIELD TO PLAY A

2697
01:37:51,920 --> 01:37:54,560
SUPPORT ON SO JUST RECOGNIZING

2698
01:37:54,560 --> 01:37:56,680
THE IMPORTANCE OF THAT REALLY

2699
01:37:56,680 --> 01:37:58,240
EARLY AND FREQUENT ENGAGEMENT.

2700
01:37:58,240 --> 01:38:01,760
AND PROMOTING INDEPENDENCE AND

2701
01:38:01,760 --> 01:38:03,120
ACCOUNTABILITY THAT REINFORCED

2702
01:38:03,120 --> 01:38:04,680
THROUGH AMBITIOUS MILESTONES AND

2703
01:38:04,680 --> 01:38:06,720
METRICS.

2704
01:38:06,720 --> 01:38:08,120
THIS WILL BE DRIVEN THROUGH THE

2705
01:38:08,120 --> 01:38:10,320
PROGRAM MANAGERS PRIMARILY.

2706
01:38:10,320 --> 01:38:16,320
WHO WILL HAVE BROAD AUTONOMY AND

2707
01:38:16,320 --> 01:38:18,320
AUTHORITY TO BE CREATIVE AND

2708
01:38:18,320 --> 01:38:19,640
DRIVE INVASION AND TRACK METRICS

2709
01:38:19,640 --> 01:38:21,520
AND MAKE DECISIONS ABOUT FUTURES

2710
01:38:21,520 --> 01:38:23,040
OF THE PROGRAM BASED ON THOSE

2711
01:38:23,040 --> 01:38:25,520
METRICS.

2712
01:38:25,520 --> 01:38:28,680
THEN OF COURSE FOLLOWING A FAIL

2713
01:38:28,680 --> 01:38:30,960
FORWARD APPROACH AND EMBRACING

2714
01:38:30,960 --> 01:38:34,320
THE ETHOS OF IF YOU ARE GOING TO

2715
01:38:34,320 --> 01:38:36,120
FAIL, FAIL EARLY AND ACCEPTING

2716
01:38:36,120 --> 01:38:38,000
FAILURE AS A NORMAL EXPECTED

2717
01:38:38,000 --> 01:38:41,520
COMPONENT OF ITS OPERATIONS SO

2718
01:38:41,520 --> 01:38:42,840
ESSENTIALLY WHAT THIS MEANS IS

2719
01:38:42,840 --> 01:38:43,760
YOU ARE FAILING IF YOU ARE NOT

2720
01:38:43,760 --> 01:38:48,200
AT LEAST FAILING OCCASIONALLY.

2721
01:38:48,200 --> 01:38:52,880
IF WE CAN MOVE TO NEXT SLIDE.

2722
01:38:52,880 --> 01:38:54,760
I WILL CALL OUT OUT AUTHORITIES

2723
01:38:54,760 --> 01:38:55,960
NEEDED TO DO THIS BECAUSE THIS

2724
01:38:55,960 --> 01:38:59,080
IS REALLY KEY AND CRITICAL TO

2725
01:38:59,080 --> 01:39:02,840
SUCCESS.

2726
01:39:02,840 --> 01:39:06,920
MOSTLY A LOT OF THEM ANYWAY ARE

2727
01:39:06,920 --> 01:39:07,920
AROUND ABILITY TO HIRE AND

2728
01:39:07,920 --> 01:39:09,400
RECRUIT THE BEST PEOPLE.

2729
01:39:09,400 --> 01:39:11,840
AND HAVING FLEXIBLE FUNDING

2730
01:39:11,840 --> 01:39:14,520
AUTHORITIES THAT ALLOW FOR USE

2731
01:39:14,520 --> 01:39:16,080
OF MULTIPLE APPROACH TO

2732
01:39:16,080 --> 01:39:17,560
DISTRIBUTE RESOURCES.

2733
01:39:17,560 --> 01:39:19,120
AND TO DO SO OVER MULTIPLE

2734
01:39:19,120 --> 01:39:20,720
YEARS.

2735
01:39:20,720 --> 01:39:22,120
SO AGAIN THIS WOULD BE THINGS

2736
01:39:22,120 --> 01:39:24,520
LIKE OTHER TRANSACTION AND PRIZE

2737
01:39:24,520 --> 01:39:27,400
AUTHORITIES AND MULTI-YEAR

2738
01:39:27,400 --> 01:39:31,880
APPROPRIATIONS.

2739
01:39:31,880 --> 01:39:33,520
THE PEER REVIEW PROCESS ARE

2740
01:39:33,520 --> 01:39:35,040
ROBUST AND EXPERT DRIVEN BUT

2741
01:39:35,040 --> 01:39:36,600
DIFFERENT THAN TRADITIONAL NIH

2742
01:39:36,600 --> 01:39:39,400
PEER REVIEW PROCESS AND

2743
01:39:39,400 --> 01:39:40,120
AUTHORITIES WOULD BE IMMEDIATED

2744
01:39:40,120 --> 01:39:42,040
TO ENSURE THIS IS POSSIBLE FOR

2745
01:39:42,040 --> 01:39:44,360
ALL MECHANISMS ESPECIALLY IF

2746
01:39:44,360 --> 01:39:44,800
PLACED WITHIN NIH

2747
01:39:44,800 --> 01:39:46,760
INFRASTRUCTURE.

2748
01:39:46,760 --> 01:39:48,760
THERE ARE OBVIOUSLY A FEW OTHER

2749
01:39:48,760 --> 01:39:50,520
THINGS LIKE EXEMPTING CERTAIN

2750
01:39:50,520 --> 01:39:53,000
INFORMATION FROM FOIA, RELATED

2751
01:39:53,000 --> 01:39:55,600
TO COMPANIES BUSINESS AND

2752
01:39:55,600 --> 01:39:58,000
COMMERCIALIZATION INVESTMENT

2753
01:39:58,000 --> 01:40:00,320
PLANS AND COLLABORATING WITH AND

2754
01:40:00,320 --> 01:40:02,440
POTENTIALLY REIMBURSING FDA FOR

2755
01:40:02,440 --> 01:40:03,120
CERTAIN ACTIVITIES.

2756
01:40:03,120 --> 01:40:05,480
AND THIS WOULD BE A WAY TO

2757
01:40:05,480 --> 01:40:07,120
FACILITATE THAT INTERACTION IN A

2758
01:40:07,120 --> 01:40:10,280
MUCH MORE ROBUST AND DEFINED

2759
01:40:10,280 --> 01:40:11,080
WAY.

2760
01:40:11,080 --> 01:40:15,560
IF WE MOVE TO THE NEXT SLIDE.

2761
01:40:15,560 --> 01:40:18,680
WE ARE ASKED QUITE A BIT ABOUT

2762
01:40:18,680 --> 01:40:21,440
WHERE IDEAS WILL COME FROM.

2763
01:40:21,440 --> 01:40:23,680
SO HERE JUST TRY TO ILLUSTRATE

2764
01:40:23,680 --> 01:40:25,920
THAT IDEAS ARE GOING TO COME

2765
01:40:25,920 --> 01:40:27,600
FROM AND FORMED BY MANY

2766
01:40:27,600 --> 01:40:28,880
DIFFERENT SOURCES.

2767
01:40:28,880 --> 01:40:32,120
PATIENTS ADVOCATES, ACADEMIA,

2768
01:40:32,120 --> 01:40:33,680
INDUSTRY AS WELL AS OTHER

2769
01:40:33,680 --> 01:40:35,200
SCIENTIFIC SAKE HOLDERS LIKE

2770
01:40:35,200 --> 01:40:37,680
FROM ACROSS THE FEDERAL

2771
01:40:37,680 --> 01:40:39,760
GOVERNMENT AND IDEAS GENERATED

2772
01:40:39,760 --> 01:40:42,120
AND REFINED BY CONSIDERING THE

2773
01:40:42,120 --> 01:40:44,000
DIVERSE ARRAY OF PERSPECTIVES,

2774
01:40:44,000 --> 01:40:45,240
BRINGING IN PEOPLE WITH

2775
01:40:45,240 --> 01:40:47,600
DIFFERENT BACKGROUNDS AND

2776
01:40:47,600 --> 01:40:48,520
EXPERTISE.

2777
01:40:48,520 --> 01:40:50,520
DIFFERENT STAKEHOLDERS,

2778
01:40:50,520 --> 01:40:51,440
DIFFERENT SCIENTIFIC

2779
01:40:51,440 --> 01:40:51,920
DISCIPLINES, DIFFERENT

2780
01:40:51,920 --> 01:40:56,200
PARTNERSHIPS AND MORE.

2781
01:40:56,200 --> 01:41:00,400
THE ARPA H DIRECTOR HAS AUTONOMY

2782
01:41:00,400 --> 01:41:01,880
TO STEP PRIORITIES AND PROVIDE

2783
01:41:01,880 --> 01:41:03,600
PROGRAM MANAGER WHOSE WILL COME

2784
01:41:03,600 --> 01:41:05,720
BEARING IDEAS WITH THE

2785
01:41:05,720 --> 01:41:06,520
INDEPENDENCE TO ENACT THAT

2786
01:41:06,520 --> 01:41:08,680
VISION.

2787
01:41:08,680 --> 01:41:11,360
WITH ROBUST SUPPORT BUT OFTEN

2788
01:41:11,360 --> 01:41:15,280
MINIMAL INVOLVEMENT FROM THE

2789
01:41:15,280 --> 01:41:16,000
DIRECTOR.

2790
01:41:16,000 --> 01:41:18,000
ESSENTIALLY WHAT THAT MEANS IS

2791
01:41:18,000 --> 01:41:19,120
HIRE REALLY GOOD SMART PEOPLE

2792
01:41:19,120 --> 01:41:20,800
AND GIVE THEM THE FREEDOM TO DO

2793
01:41:20,800 --> 01:41:21,520
WHAT THEY DO BEST.

2794
01:41:21,520 --> 01:41:23,800
THAT'S WHAT ARPA H PROGRAM

2795
01:41:23,800 --> 01:41:24,760
MANAGERS WILL BE DOING, THEY

2796
01:41:24,760 --> 01:41:27,280
WILL BE RESPONSIBLE FOR TAKING

2797
01:41:27,280 --> 01:41:28,320
IN FEEDBACK FROM ALL THESE

2798
01:41:28,320 --> 01:41:30,840
DIFFERENT SOURCES, THAT THEY ARE

2799
01:41:30,840 --> 01:41:31,920
RECEIVING.

2800
01:41:31,920 --> 01:41:38,320
AND DRAFTING OLD PROGRAMS NEXT

2801
01:41:38,320 --> 01:41:40,160
SLIDE WE DON'T HAVE THE GOOD

2802
01:41:40,160 --> 01:41:41,760
IDEAS AND KNOW CHALLENGES AND

2803
01:41:41,760 --> 01:41:45,040
ISSUES FACING THE COMMUNITY WE

2804
01:41:45,040 --> 01:41:47,520
HAVE BEEN TRYING TO FIRST

2805
01:41:47,520 --> 01:41:48,640
FOREMOST SHARE INFORMATION ABOUT

2806
01:41:48,640 --> 01:41:53,160
ARPA H AS AVAILABLE ALSO MORE

2807
01:41:53,160 --> 01:41:57,920
IMPORTANTLY TO HEAR FROM THE

2808
01:41:57,920 --> 01:42:00,120
COMMUNITY.

2809
01:42:00,120 --> 01:42:03,400
TO DATE NIH AND OSTP HELD AN

2810
01:42:03,400 --> 01:42:05,120
INFORMATION SESSION AVAILABLE

2811
01:42:05,120 --> 01:42:07,440
ONLINE, PUBLISHED COMMENTARY IN

2812
01:42:07,440 --> 01:42:10,320
SCIENCE AND HAS HELD NUMEROUS

2813
01:42:10,320 --> 01:42:11,680
MEETINGS WITH DIFFERENT

2814
01:42:11,680 --> 01:42:13,120
ORGANIZATIONS, VARIETY OF

2815
01:42:13,120 --> 01:42:14,320
DIFFERENT PRESENTATIONS, SUCH AS

2816
01:42:14,320 --> 01:42:17,320
THIS.

2817
01:42:17,320 --> 01:42:19,760
WE ALSO UNDERTOOK A SERIES OF

2818
01:42:19,760 --> 01:42:20,920
LISTENING SESSIONS.

2819
01:42:20,920 --> 01:42:22,200
TO HEAR FROM DIFFERENT VOICES

2820
01:42:22,200 --> 01:42:27,400
ACROSS THE COMMUNITY.

2821
01:42:27,400 --> 01:42:30,000
GO TO NEXT SLIDE SUMMARIZE THOSE

2822
01:42:30,000 --> 01:42:31,800
LISTENING SESSIONS WHICH WERE

2823
01:42:31,800 --> 01:42:33,360
LED BY LEADERSHIP FROM ACROSS

2824
01:42:33,360 --> 01:42:37,760
THE OSPTP AND NIH INCLUDE ALL 27

2825
01:42:37,760 --> 01:42:38,880
INSTITUTE AND CENTER DIRECTORS

2826
01:42:38,880 --> 01:42:40,080
AND JONI PARTICIPATED IN ONE OF

2827
01:42:40,080 --> 01:42:42,040
THOSE.

2828
01:42:42,040 --> 01:42:46,320
OVER THE COURSE OF WE HAD 15

2829
01:42:46,320 --> 01:42:51,000
SESSIONS AND THEN ONE FEEDBACK

2830
01:42:51,000 --> 01:42:51,440
SESSION, 16.

2831
01:42:51,440 --> 01:42:53,920
WE HEARD FROM OVER 5100

2832
01:42:53,920 --> 01:42:56,000
STAKEHOLDERS INCLUDING NEARLY

2833
01:42:56,000 --> 01:42:57,000
250 ORGANIZATIONS FROM ALL OVER

2834
01:42:57,000 --> 01:42:58,960
THE COUNTRY.

2835
01:42:58,960 --> 01:43:00,440
I HOPE MANY OF YOU ARE ABLE TO

2836
01:43:00,440 --> 01:43:03,400
PARTICIPATE IN THOSE.

2837
01:43:03,400 --> 01:43:06,400
WHAT CAME OUT OF THAT IS SEVERAL

2838
01:43:06,400 --> 01:43:08,120
THEMES THAT WE HAVE GROUPED INTO

2839
01:43:08,120 --> 01:43:11,800
TWO MAIN BUCKETS.

2840
01:43:11,800 --> 01:43:12,480
COMMENTS ON THE NATURE OF

2841
01:43:12,480 --> 01:43:13,560
SCIENTIFIC PORTFOLIO AND THE KEY

2842
01:43:13,560 --> 01:43:17,280
ASPECT ON WHICH TO FOCUS AS WELL

2843
01:43:17,280 --> 01:43:19,360
AS THE ADOPTION OF STREAMLINE

2844
01:43:19,360 --> 01:43:21,040
YET NIMBLE PROCESSES FOR

2845
01:43:21,040 --> 01:43:23,200
FLEXIBILITY AND BROAD INCLUSION.

2846
01:43:23,200 --> 01:43:28,160
I FOR GOT TO SAY -- HERE IS AN

2847
01:43:28,160 --> 01:43:29,600
ANIMATION HERE BUT IF WE CAN

2848
01:43:29,600 --> 01:43:31,040
MOVE FORWARD TWO NOW.

2849
01:43:31,040 --> 01:43:31,880
THAT WOULD BE GOOD BECAUSE I

2850
01:43:31,880 --> 01:43:33,120
WILL TALK ABOUT THAT A LITTLE

2851
01:43:33,120 --> 01:43:33,520
BIT FURTHER.

2852
01:43:33,520 --> 01:43:38,240
SO IF WE MOVE TO THE NEXT SLIDE.

2853
01:43:38,240 --> 01:43:41,680
THE AREAS OF FOCUS ON THE

2854
01:43:41,680 --> 01:43:43,840
PORTFOLIO IN TERMS OF FEEDBACK

2855
01:43:43,840 --> 01:43:45,920
WE RECEIVE REALLY CENTERED

2856
01:43:45,920 --> 01:43:48,320
AROUND THE NEED TO COMPLIMENT

2857
01:43:48,320 --> 01:43:50,360
NIH RESEARCH PORTFOLIO AND NOT

2858
01:43:50,360 --> 01:43:52,280
DUPLICATE IT AND OF COURSE THAT

2859
01:43:52,280 --> 01:43:53,800
SOMETHING THAT WE OBVIOUSLY ARE

2860
01:43:53,800 --> 01:43:56,080
VERY KEENLY AWARE OF AND WANT TO

2861
01:43:56,080 --> 01:43:57,720
TAKE STEPS TO AVOID.

2862
01:43:57,720 --> 01:43:59,920
AND REALLY TO ALSO NOT JUST

2863
01:43:59,920 --> 01:44:03,360
AVOID DUPLICATION BUT IDENTIFY

2864
01:44:03,360 --> 01:44:07,240
AREAS FOR COLLABORATION AND

2865
01:44:07,240 --> 01:44:11,920
SYNERGY TO ENHANCE EFFORTS

2866
01:44:11,920 --> 01:44:12,800
ACROSS BOTH ORGANIZATIONS

2867
01:44:12,800 --> 01:44:14,600
WHETHER ARPA H OR NIH INSTITUTES

2868
01:44:14,600 --> 01:44:18,280
AND CENTERS.

2869
01:44:18,280 --> 01:44:20,240
WE ALSO HEARD ROBUSTLY ABOUT THE

2870
01:44:20,240 --> 01:44:21,800
IMPORTANCE AND CRITICALITY OF

2871
01:44:21,800 --> 01:44:23,520
ADDRESSING HEALTH INEQUITIES.

2872
01:44:23,520 --> 01:44:27,560
AND PROMOTING HEALTH EQUITY AND

2873
01:44:27,560 --> 01:44:28,920
THIS IS IMPORTANT TO THE

2874
01:44:28,920 --> 01:44:30,280
ADMINISTRATION BROADLY AND

2875
01:44:30,280 --> 01:44:31,760
SOMETHING WE IN THINKING ABOUT

2876
01:44:31,760 --> 01:44:33,800
SETTING UP A NEW ORGANIZATION WE

2877
01:44:33,800 --> 01:44:35,240
WANT TO BUILD IN TO IT FROM ITS

2878
01:44:35,240 --> 01:44:41,640
FOUNDATION.

2879
01:44:41,640 --> 01:44:43,760
WE HEARD A DESIRE TO HAVE -- TO

2880
01:44:43,760 --> 01:44:45,120
BUILD TECHNOLOGIES, PLATFORMS

2881
01:44:45,120 --> 01:44:47,320
THAT ARE REALLY BROADLY

2882
01:44:47,320 --> 01:44:52,440
APPLICABLE THAT ARE NOT DISEASE

2883
01:44:52,440 --> 01:44:55,800
SPECIFIC.

2884
01:44:55,800 --> 01:44:58,800
ALSO WE HEARD BROADLY ABOUT

2885
01:44:58,800 --> 01:45:00,240
EVERY SINGLE COMMENT YOU CAN

2886
01:45:00,240 --> 01:45:03,040
IMAGINE ABOUT DATA SO THINKING

2887
01:45:03,040 --> 01:45:04,680
ABOUT ACCESSIBILITY INTEGRATION

2888
01:45:04,680 --> 01:45:05,520
SHARING STANDARDS TOOLS, ET

2889
01:45:05,520 --> 01:45:07,520
CETERA.

2890
01:45:07,520 --> 01:45:09,440
HOW TO LEVERAGE AI IN CREATIVE

2891
01:45:09,440 --> 01:45:10,840
AND UNIQUE WAYS.

2892
01:45:10,840 --> 01:45:13,240
AND FOCUS ON COMMERCIALIZATION

2893
01:45:13,240 --> 01:45:15,680
AND PUSHING PRODUCT CLOSER TO

2894
01:45:15,680 --> 01:45:21,040
MARK TO GET TO PATIENTS.

2895
01:45:21,040 --> 01:45:24,240
WE HEARD ABOUT PROCESSES.

2896
01:45:24,240 --> 01:45:25,840
AND THE MAIN TAKE HOME HERE IS

2897
01:45:25,840 --> 01:45:26,840
THE NEED THE STREAMLINE

2898
01:45:26,840 --> 01:45:29,880
PROCESSES TO EXPEDITE DISCOVERY

2899
01:45:29,880 --> 01:45:31,200
THROUGH INTEGRATION OF THE

2900
01:45:31,200 --> 01:45:32,920
COMMUNITY PATIENTS AND THEIR

2901
01:45:32,920 --> 01:45:34,680
PROVIDERS EARLY IN THE PROCESS

2902
01:45:34,680 --> 01:45:38,280
AS MENTIONED BEFORE.

2903
01:45:38,280 --> 01:45:39,360
BUT BUILDING MULTI-DISCIPLINARY

2904
01:45:39,360 --> 01:45:41,560
COLLABORATION AND PARTNERSHIPS,

2905
01:45:41,560 --> 01:45:44,680
SO DRAWING IN SCIENTISTS FROM

2906
01:45:44,680 --> 01:45:45,920
OTHER DISCIPLINES, HOW WE CAN

2907
01:45:45,920 --> 01:45:49,400
PULL IN FOLKS FROM CHEMISTRY OR

2908
01:45:49,400 --> 01:45:51,680
MATH OR PHYSICS.

2909
01:45:51,680 --> 01:45:52,560
ENGINEERING.

2910
01:45:52,560 --> 01:45:56,240
I KNOW THIS IS SOMETHING THAT

2911
01:45:56,240 --> 01:46:01,320
THERE IS A PUSH FOR THIS ACROSS

2912
01:46:01,320 --> 01:46:02,880
SCIENCE, THAT WAS EMPHASIZED WE

2913
01:46:02,880 --> 01:46:05,520
SHOULD FOCUS ON WITH ARPA H AND

2914
01:46:05,520 --> 01:46:06,760
WORKING WITH INDUSTRY

2915
01:46:06,760 --> 01:46:07,680
NON-PROFITS AND OTHERS IN THE

2916
01:46:07,680 --> 01:46:10,280
PRIVATE SECTOR.

2917
01:46:10,280 --> 01:46:13,640
SO GO TO NEXT SLIDE.

2918
01:46:13,640 --> 01:46:15,640
BACK IN SEPTEMBER WE RELEASED A

2919
01:46:15,640 --> 01:46:16,920
REPORT SUMMARIZING THE FEEDBACK,

2920
01:46:16,920 --> 01:46:18,920
THAT IS AVAILABLE ON LINE, ON

2921
01:46:18,920 --> 01:46:20,760
THE OSTP AND I BELIEVE ALSO

2922
01:46:20,760 --> 01:46:23,200
POSTED ON THE HIPPOWEBSITE.

2923
01:46:23,200 --> 01:46:26,040
AS I MENTIONED -- NIH WEBSITE.

2924
01:46:26,040 --> 01:46:27,360
WE HELD A FOLLOW-UP LISTENING

2925
01:46:27,360 --> 01:46:29,720
AND FEEDBACK SESSION TO ENSURE

2926
01:46:29,720 --> 01:46:34,520
THAT WHAT WE HEARD INDICATED TO

2927
01:46:34,520 --> 01:46:37,280
US WE CAPTURED IN OUR ELEMENTS

2928
01:46:37,280 --> 01:46:40,520
AND THAT WE WERE HEARING FOLKS

2929
01:46:40,520 --> 01:46:42,680
CORRECTLY.

2930
01:46:42,680 --> 01:46:44,920
WE ALSO HOOKED TOGETHER

2931
01:46:44,920 --> 01:46:45,720
ADDITIONAL FEEDBACK HOW TO

2932
01:46:45,720 --> 01:46:47,200
ENGAGE WITH THE COMMUNITY.

2933
01:46:47,200 --> 01:46:52,160
IF YOU MOVE TO THE NEXT SLIDE.

2934
01:46:52,160 --> 01:46:54,520
JUST SORT OF UPDATE I GUESS OR

2935
01:46:54,520 --> 01:46:59,560
REMINDER MAYBE WHERE THINGS

2936
01:46:59,560 --> 01:47:00,640
STAND.

2937
01:47:00,640 --> 01:47:03,520
THE PRESIDENT IN HIS FY 22

2938
01:47:03,520 --> 01:47:06,320
BUDGET REQUEST INCLUDED

2939
01:47:06,320 --> 01:47:09,680
$6.5 BILLION FOR ARPA H, NOW THE

2940
01:47:09,680 --> 01:47:13,320
HOUSE INCLUDED ARPA H IN THEIR

2941
01:47:13,320 --> 01:47:16,560
DRAFT FY 22 APPROPRIATIONS BILL

2942
01:47:16,560 --> 01:47:19,440
AND PUT FORTH 3 BILLION IN

2943
01:47:19,440 --> 01:47:19,920
APPROPRIATIONS.

2944
01:47:19,920 --> 01:47:23,240
WE SAW SIMILAR LANGUAGE ON THE

2945
01:47:23,240 --> 01:47:26,120
SENATE SIDE WITH BUDGET OF

2946
01:47:26,120 --> 01:47:29,040
2.4 BILLION SO OF COURSE THE FY

2947
01:47:29,040 --> 01:47:32,240
22 APPROPRIATION HASN'T

2948
01:47:32,240 --> 01:47:33,720
OFFICIALLY MOVED FORWARD OR

2949
01:47:33,720 --> 01:47:36,320
PASSED YET SO WE ARE KIND OF IN

2950
01:47:36,320 --> 01:47:38,120
A WAITING STATUS THERE TO SEE

2951
01:47:38,120 --> 01:47:41,560
HOW THIS ALL PLAYS OUT AND WHERE

2952
01:47:41,560 --> 01:47:43,320
IT ENDS UP GETTING FINALIZED IN

2953
01:47:43,320 --> 01:47:45,080
THE MIDDLE.

2954
01:47:45,080 --> 01:47:47,720
IF YOU MOVE TO NEXT SLIDE IN

2955
01:47:47,720 --> 01:47:50,480
TERMS OF OUR AUTHORIZATION,

2956
01:47:50,480 --> 01:47:52,320
THERE ARE COUPLE OF OPTIONS FOR

2957
01:47:52,320 --> 01:47:54,880
AUTHORIZATION THAT HAVE BEEN

2958
01:47:54,880 --> 01:47:55,880
INTRODUCED.

2959
01:47:55,880 --> 01:47:58,280
THERE WAS A BILL REPRESENTATIVE

2960
01:47:58,280 --> 01:48:00,520
ESCHEW RELEASED IN OCTOBER AND

2961
01:48:00,520 --> 01:48:05,480
THE CARES 2.0 BILL THAT

2962
01:48:05,480 --> 01:48:08,200
REPRESENTATIVES UPTON INTRODUCED

2963
01:48:08,200 --> 01:48:09,640
IN OCTOBER AND WE HOPE TO SEE

2964
01:48:09,640 --> 01:48:10,320
MOVEMENT SOON.

2965
01:48:10,320 --> 01:48:12,680
ONE THING I WILL SAY IS IN

2966
01:48:12,680 --> 01:48:14,120
ADDITION TO PRESIDENTIAL SUPPORT

2967
01:48:14,120 --> 01:48:19,320
THIS INITIATIVE HAS, WE'VE HEARD

2968
01:48:19,320 --> 01:48:21,920
GREAT BIPARTISAN CONGRESSIONAL

2969
01:48:21,920 --> 01:48:24,400
SUPPORT AND SO OPTIMISTIC ABOUT

2970
01:48:24,400 --> 01:48:27,520
IT, ITS SUCCESS FOR HOPEFULLY FY

2971
01:48:27,520 --> 01:48:32,560
22 BUT FOR THE FUTURE.

2972
01:48:32,560 --> 01:48:33,680
SO YOU GO TO THE FINAL SLIDE I

2973
01:48:33,680 --> 01:48:35,400
BELIEVE.

2974
01:48:35,400 --> 01:48:37,320
THE TAKE HOME HERE IS THAT WE

2975
01:48:37,320 --> 01:48:39,120
KNOW THIS ARPA MODEL WORKS.

2976
01:48:39,120 --> 01:48:44,400
AND WE HAVE SEEN HOW SUCCESSFUL

2977
01:48:44,400 --> 01:48:45,000
DARPA HAS BEEN.

2978
01:48:45,000 --> 01:48:47,000
THERE ARE SO MANY AREAS RIPE FOR

2979
01:48:47,000 --> 01:48:47,360
TRANSFORMATION.

2980
01:48:47,360 --> 01:48:50,680
WE JUST NEED TO HARNESS AND

2981
01:48:50,680 --> 01:48:54,200
FOSTER THEM SO THAT WE CAN TAKE

2982
01:48:54,200 --> 01:48:55,400
THESE POTENTIAL OPPORTUNITIES TO

2983
01:48:55,400 --> 01:48:58,240
SHAPE THE FUTURE OF HEALTH AND

2984
01:48:58,240 --> 01:49:01,120
MEDICINE AND SIGNIFICANTLY

2985
01:49:01,120 --> 01:49:02,160
IMPROVE QUALITY OF LIFE FOR ALL

2986
01:49:02,160 --> 01:49:03,320
AMERICANS BY LEVERAGING THIS

2987
01:49:03,320 --> 01:49:06,680
MODEL WE KNOW WORKS.

2988
01:49:06,680 --> 01:49:08,560
SO WITH THAT JONI, I DON'T KNOW

2989
01:49:08,560 --> 01:49:10,120
I THINK WE STILL HAVE A FEW

2990
01:49:10,120 --> 01:49:11,760
MINUTES OR QUESTIONS OR

2991
01:49:11,760 --> 01:49:12,360
COMMENTS?

2992
01:49:12,360 --> 01:49:13,360
>> THANK YOU SO MUCH.

2993
01:49:13,360 --> 01:49:14,520
REALLY APPRECIATE IT.

2994
01:49:14,520 --> 01:49:17,080
WE DO HAVE A FEW MINUTES FOR

2995
01:49:17,080 --> 01:49:17,320
QUESTIONS.

2996
01:49:17,320 --> 01:49:18,600
PAUL I SEE YOUR HAND FIRST

2997
01:49:18,600 --> 01:49:19,560
PLEASE GO AHEAD.

2998
01:49:19,560 --> 01:49:20,400
>> TARA GREAT JOB.

2999
01:49:20,400 --> 01:49:22,440
THANK YOU FOR THAT PRESENTATION.

3000
01:49:22,440 --> 01:49:25,920
WHERE DO YOU SEE OR WHERE DO THE

3001
01:49:25,920 --> 01:49:26,680
GROUP THINKING ABOUT THIS MOST

3002
01:49:26,680 --> 01:49:30,680
SEE THE IC RECORDS SITTING HERE?

3003
01:49:30,680 --> 01:49:31,920
I'M THINKING ONE LEVEL DOWN

3004
01:49:31,920 --> 01:49:33,560
MAKING SURE WE DON'T HAVE THAT

3005
01:49:33,560 --> 01:49:37,160
DUPLICATION OF EFFORT AND

3006
01:49:37,160 --> 01:49:38,680
FOCUSING ON THE RIGHT PROBLEMS.

3007
01:49:38,680 --> 01:49:43,680
>> OVER THE SUMMER AND INTO

3008
01:49:43,680 --> 01:49:47,680
FALL, THE NIH LEADERSHIP

3009
01:49:47,680 --> 01:49:52,880
CONVENED A GROUP OF IC DIRECTORS

3010
01:49:52,880 --> 01:49:53,840
THINK THROUGH HOW HAY WORK

3011
01:49:53,840 --> 01:49:55,400
TOGETHER AND I CAN'T RECALL JONI

3012
01:49:55,400 --> 01:49:56,400
IF YOU WERE ON THAT GROUP.

3013
01:49:56,400 --> 01:49:56,880
>> YES.

3014
01:49:56,880 --> 01:49:59,920
>> I KNOW I SPOKE AT THEM ONCE

3015
01:49:59,920 --> 01:50:00,320
OR TWICE.

3016
01:50:00,320 --> 01:50:02,040
THEY PROVIDED SOME REALLY GREAT

3017
01:50:02,040 --> 01:50:04,360
FEEDBACK IN THINKING THROUGH HOW

3018
01:50:04,360 --> 01:50:09,560
WE CAN COORDINATE, HOW WE COULD

3019
01:50:09,560 --> 01:50:10,600
ENSURE THAT THERE WAS AN

3020
01:50:10,600 --> 01:50:14,120
EXCHANGE OF IDEAS AND EXCHANGE

3021
01:50:14,120 --> 01:50:15,120
OF INFORMATION ACROSS THEM.

3022
01:50:15,120 --> 01:50:17,760
GOING FORWARD THERE'S A COUPLE

3023
01:50:17,760 --> 01:50:20,840
OF AREAS WE CAN ENOR ENVISION

3024
01:50:20,840 --> 01:50:22,760
COLLABORATION BETWEEN ARPA H AND

3025
01:50:22,760 --> 01:50:25,920
ICs AND THAT'S FIRST AND

3026
01:50:25,920 --> 01:50:28,320
FOREMOST REVIEW PROCESS WILL BE

3027
01:50:28,320 --> 01:50:31,120
MOSTLY HEARD OF FEDERAL DRIVEN

3028
01:50:31,120 --> 01:50:33,560
PROCESS AND WE'LL NEED EXPERT

3029
01:50:33,560 --> 01:50:35,800
REVIEWERS TO REVIEW SOME OF THE

3030
01:50:35,800 --> 01:50:37,080
ARPA H APPLICATIONS.

3031
01:50:37,080 --> 01:50:41,120
SO THAT TO ME IS A GREAT WAY TO

3032
01:50:41,120 --> 01:50:44,360
HAVE INVOLVEMENT AND TO LEVERAGE

3033
01:50:44,360 --> 01:50:46,160
EXPERTISE OF DIFFERENT ICs.

3034
01:50:46,160 --> 01:50:47,680
WE ALSO KNOW THERE'S GOING TO BE

3035
01:50:47,680 --> 01:50:50,520
SOURCES OF IDEAS AND SO SHOULD

3036
01:50:50,520 --> 01:50:53,320
-- GOING TO TRY TO THINK THROUGH

3037
01:50:53,320 --> 01:50:55,920
A FEEDBACK LOOP IF YOU WILL FOR

3038
01:50:55,920 --> 01:50:57,680
DEVELOPMENT OF THOSE IDEAS AND

3039
01:50:57,680 --> 01:50:59,160
WHAT EXACTLY THAT MEANS AND LOOK

3040
01:50:59,160 --> 01:50:59,520
LIKE.

3041
01:50:59,520 --> 01:51:01,000
AND I THINK WITH ARPA H

3042
01:51:01,000 --> 01:51:02,480
ESPECIALLY AS THIS IS GETTING

3043
01:51:02,480 --> 01:51:05,480
DEVELOPED, THIS IS NOT LIMITED

3044
01:51:05,480 --> 01:51:08,120
TO THE OTHER NIH ICs BUT

3045
01:51:08,120 --> 01:51:09,480
BROADER ACROSS THE FEDERAL

3046
01:51:09,480 --> 01:51:11,680
GOVERNMENT, WE WANT TO MAKE SURE

3047
01:51:11,680 --> 01:51:14,040
THAT PEOPLE ARE AWARE OF AND

3048
01:51:14,040 --> 01:51:15,920
SUPPORTIVE OF ARPA H AND WHAT IT

3049
01:51:15,920 --> 01:51:18,520
IS DOING AND TRYING TO THINK

3050
01:51:18,520 --> 01:51:21,880
THROUGH REALLY ROBUST WAYS TO

3051
01:51:21,880 --> 01:51:23,720
FACILITATE STAFF INTERACTION AND

3052
01:51:23,720 --> 01:51:29,400
EVEN DETAILS AND OTHER WORK KIND

3053
01:51:29,400 --> 01:51:31,000
OF EXCHANGE OPPORTUNITIES AS WE

3054
01:51:31,000 --> 01:51:33,120
CONTINUE TO BUILD UP THIS EFFORT

3055
01:51:33,120 --> 01:51:34,720
AND WE DISCUSSED THESE ALSO ON

3056
01:51:34,720 --> 01:51:36,520
THE INTERAGENCY LEVEL TOO

3057
01:51:36,520 --> 01:51:37,360
BECAUSE WE HAVE INTERAGENCY

3058
01:51:37,360 --> 01:51:39,800
COMMITTEE.

3059
01:51:39,800 --> 01:51:42,560
>> THANKS.

3060
01:51:42,560 --> 01:51:44,320
RAJESH YOU HAD YOUR HAND UP.

3061
01:51:44,320 --> 01:51:47,520
>> AS SOMEONE WHO SORT OF WORKED

3062
01:51:47,520 --> 01:51:49,840
INDUSTRY CAME TO NIH THEN LEFT

3063
01:51:49,840 --> 01:51:52,320
NIH GO BACK TO ACADEMIA AND

3064
01:51:52,320 --> 01:51:53,760
INDUSTRY, I WOULD RAISE A COUPLE

3065
01:51:53,760 --> 01:51:55,560
OF THINGS THAT I -- YOU MIGHT

3066
01:51:55,560 --> 01:51:57,120
HAVE HEARD ME TALK ABOUT.

3067
01:51:57,120 --> 01:51:59,040
THIS MODEL OF ESSENTIALLY HIRING

3068
01:51:59,040 --> 01:52:04,200
WORK FORCE THAT IS TERM LIMITED

3069
01:52:04,200 --> 01:52:06,920
IS RUNS COUNTER TO THE

3070
01:52:06,920 --> 01:52:08,560
COMPENSATION SCHEME AVAILABLE IN

3071
01:52:08,560 --> 01:52:09,160
THE GOVERNMENT.

3072
01:52:09,160 --> 01:52:11,680
SO IF YOU ARE PLANNING TO HIRE

3073
01:52:11,680 --> 01:52:13,240
THE BIGGEST BEST AND BRIGHTEST

3074
01:52:13,240 --> 01:52:16,680
INCLUDING THE DIRECTOR OF ARPA

3075
01:52:16,680 --> 01:52:18,800
H, YOU CAN PAY A PERSON THESE

3076
01:52:18,800 --> 01:52:20,600
PRESIDENT SALARY, NOT SURE YOU

3077
01:52:20,600 --> 01:52:22,720
ARE GOING TO GET A LIST

3078
01:52:22,720 --> 01:52:23,400
CHARACTERS.

3079
01:52:23,400 --> 01:52:25,560
SO I'M VERY SKEPTICAL ABOUT THAT

3080
01:52:25,560 --> 01:52:27,160
PARTICULAR PIECE OF HOW YOU WILL

3081
01:52:27,160 --> 01:52:28,880
STRUCTURE AND IF IT WILL SIT

3082
01:52:28,880 --> 01:52:30,000
WITHIN THE NIH.

3083
01:52:30,000 --> 01:52:31,680
THE OTHER PART I GUESS LINKED TO

3084
01:52:31,680 --> 01:52:35,440
THE IC QUESTION, WILL THIS BE AN

3085
01:52:35,440 --> 01:52:37,360
IC, WILL THIS BE SAME SANDING OF

3086
01:52:37,360 --> 01:52:40,040
IC, WILL IT BE OFFICE?

3087
01:52:40,040 --> 01:52:40,720
WHAT IS IT STRUCTURE?

3088
01:52:40,720 --> 01:52:42,320
I WAS INVOLVED IN THE STANDING

3089
01:52:42,320 --> 01:52:45,880
UP OF NCATS, THERE IS A 19

3090
01:52:45,880 --> 01:52:50,200
WHATEVER -- 79 OR 89 LAW, 26

3091
01:52:50,200 --> 01:52:51,000
INSTITUTES AT NIH.

3092
01:52:51,000 --> 01:52:52,840
SO IF ONE NEEDS TO CREATE A NEW

3093
01:52:52,840 --> 01:52:56,520
ONE, ONE NEEDS TO DISAPPEAR.

3094
01:52:56,520 --> 01:52:58,840
LAST TIME IT WAS NCRR TO CREATE

3095
01:52:58,840 --> 01:52:59,240
NCATS.

3096
01:52:59,240 --> 01:53:03,880
SO THAT'S BEGS THE QUESTION TO

3097
01:53:03,880 --> 01:53:05,040
WHAT LEVEL THIS IS BEING SET UP.

3098
01:53:05,040 --> 01:53:06,880
LINKED TO THAT QUESTION IS NCATS

3099
01:53:06,880 --> 01:53:09,880
COUNCIL MEMBER, I GUESS I WOULD

3100
01:53:09,880 --> 01:53:13,920
JUST RAISE THE PRESENTATION AND

3101
01:53:13,920 --> 01:53:15,920
VALUES YOU ESPOUSED AND ETHOS

3102
01:53:15,920 --> 01:53:17,520
YOU WANT THERE, THESE ARE THINGS

3103
01:53:17,520 --> 01:53:19,360
THAT WE ARE SEEING IN PRACTICE

3104
01:53:19,360 --> 01:53:21,040
BEING PUT MANY PLAY BY THE NCATS

3105
01:53:21,040 --> 01:53:25,920
STAFF.

3106
01:53:25,920 --> 01:53:28,880
SO HOW SHALL I PUT IT, A

3107
01:53:28,880 --> 01:53:31,560
VOLKSWAGEN AND AUDI ARE ON THE

3108
01:53:31,560 --> 01:53:35,480
SAME CHASSI.

3109
01:53:35,480 --> 01:53:37,800
SO IS CAMRY AND INFINITY.

3110
01:53:37,800 --> 01:53:40,400
SO IF THERE IS A REQUIREMENT FOR

3111
01:53:40,400 --> 01:53:41,520
REBRANDING THAT WOULD MAKE A

3112
01:53:41,520 --> 01:53:43,120
DIFFERENCE OKAY WE CAN SEPTEMBER

3113
01:53:43,120 --> 01:53:45,040
THAT BUT YOU GOT A FRAMEWORK --

3114
01:53:45,040 --> 01:53:46,680
ACCEPT THAT, BUT YOU HAVE A

3115
01:53:46,680 --> 01:53:47,960
FRAMEWORK OF SOMETHING WHY NOT

3116
01:53:47,960 --> 01:53:49,080
USE WHAT YOU HAVE TO BUILD WHAT

3117
01:53:49,080 --> 01:53:53,480
YOU NEED TO DO RATHER THAN

3118
01:53:53,480 --> 01:53:55,040
COMPLETELY REINVENT SOMETHING

3119
01:53:55,040 --> 01:53:55,520
NEW.

3120
01:53:55,520 --> 01:53:57,680
I WORRY A LITTLE BIT ABOUT THE

3121
01:53:57,680 --> 01:54:00,240
NIH SYNDROME, CALL IT NOT

3122
01:54:00,240 --> 01:54:01,200
INVENTED HERE SYNDROME IN PLAY

3123
01:54:01,200 --> 01:54:03,120
HERE.

3124
01:54:03,120 --> 01:54:05,920
SO I'M RAISING -- BEING GLASS

3125
01:54:05,920 --> 01:54:07,480
HALF EMPTY HERE BUT ON BEHALF OF

3126
01:54:07,480 --> 01:54:09,800
N CATS I'M CONCERNED HOW ARPA H

3127
01:54:09,800 --> 01:54:11,920
SETS ITSELF UP FOR SUCCESS, THE

3128
01:54:11,920 --> 01:54:13,920
GOAL IS LAUDABLE BUT THE -- IN

3129
01:54:13,920 --> 01:54:15,120
AN OPERATIONAL WAY TO GET THE

3130
01:54:15,120 --> 01:54:17,160
RIGHT PEOPLE YOU GOT TO PAY THEM

3131
01:54:17,160 --> 01:54:18,360
THE RIGHT AMOUNT TO GIVE THEM

3132
01:54:18,360 --> 01:54:19,680
THE AUTONOMY BUT IN THE

3133
01:54:19,680 --> 01:54:20,600
STRUCTURE OF THE NIH HOW ARE YOU

3134
01:54:20,600 --> 01:54:22,520
GOING TO MAKE THAT HAPPEN?

3135
01:54:22,520 --> 01:54:24,680
>> I THINK A LOT OF IT TIES BACK

3136
01:54:24,680 --> 01:54:28,760
TO THE SHORT ANSWER FOR ALL

3137
01:54:28,760 --> 01:54:31,880
THREE OF THOSE QUESTIONS, REALLY

3138
01:54:31,880 --> 01:54:33,520
TIES BACK TO AUTHORITIES THAT

3139
01:54:33,520 --> 01:54:34,840
ARE NEEDED.

3140
01:54:34,840 --> 01:54:36,320
THESE ARE THINGS WE HAVE BEEN

3141
01:54:36,320 --> 01:54:39,920
WORKING VERY CLOSELY WITH THE

3142
01:54:39,920 --> 01:54:42,040
HILL ON IN GIVING TECHNICAL

3143
01:54:42,040 --> 01:54:44,720
ASSISTANCE WHERE NEEDED.

3144
01:54:44,720 --> 01:54:47,480
TO PROVIDE RATIONALE FOR WHY WE

3145
01:54:47,480 --> 01:54:49,480
DO THINK THAT IT IS IMPORTANT

3146
01:54:49,480 --> 01:54:52,000
FOR ARPA H TO HAVE FOR EXAMPLE

3147
01:54:52,000 --> 01:54:55,480
REALLY ROBUST FLEXIBLE HIRING

3148
01:54:55,480 --> 01:54:55,880
AUTHORITIES.

3149
01:54:55,880 --> 01:54:58,360
BECAUSE AS YOU INDICATED, THERE

3150
01:54:58,360 --> 01:55:04,480
ARE LIMITATIONS THERE.

3151
01:55:04,480 --> 01:55:07,160
WE HOPE SOME LEVEL ONE OF THE

3152
01:55:07,160 --> 01:55:09,080
THINGS THAT WE WILL ARACKET

3153
01:55:09,080 --> 01:55:13,920
FOLKS TO IS THE ABILITY

3154
01:55:13,920 --> 01:55:16,040
ESPECIALLY WITH FIRST INSTRUCTOR

3155
01:55:16,040 --> 01:55:18,240
TO SHAPE AND MOLD THIS

3156
01:55:18,240 --> 01:55:20,600
ORGANIZATION BUT ALSO THE

3157
01:55:20,600 --> 01:55:21,400
POTENTIAL OPPORTUNITIES THAT

3158
01:55:21,400 --> 01:55:24,360
EXIST SO WE ARE GOING TO BE

3159
01:55:24,360 --> 01:55:26,120
CONFINED BY CERTAIN

3160
01:55:26,120 --> 01:55:27,560
RESTRICTIONS, OPERATING WITHIN

3161
01:55:27,560 --> 01:55:29,880
THE FEDERAL GOVERNMENT BUT

3162
01:55:29,880 --> 01:55:34,200
HAVING AS FLEXIBLE OF AUTHORITY

3163
01:55:34,200 --> 01:55:35,560
AS POSSIBLE WILL BE REALLY

3164
01:55:35,560 --> 01:55:35,920
HELPFUL.

3165
01:55:35,920 --> 01:55:38,760
SO HA IS THE FIRST POINT.

3166
01:55:38,760 --> 01:55:40,840
THE SECOND QUESTION, I'M FAILING

3167
01:55:40,840 --> 01:55:45,520
THIS COGNITIVE TEST, WAS AROUND

3168
01:55:45,520 --> 01:55:46,720
REALLY -- REMIND ME.

3169
01:55:46,720 --> 01:55:49,720
>> ABOUT THE ICs, WHERE WILL

3170
01:55:49,720 --> 01:55:51,480
IT STAND, IS THE STRUCTURE.

3171
01:55:51,480 --> 01:55:53,920
>> YEAH.

3172
01:55:53,920 --> 01:55:55,040
SO THE STRUCTURAL ORGANIZATION

3173
01:55:55,040 --> 01:55:59,720
THAT BEING CONSIDERED RIGHT NOW,

3174
01:55:59,720 --> 01:56:03,520
IT WILL HINGE ON THE LANGUAGE IN

3175
01:56:03,520 --> 01:56:07,840
THE FINAL BILLS FOR THIS BECAUSE

3176
01:56:07,840 --> 01:56:09,280
AGAIN THIS IS STILL PROPOSAL

3177
01:56:09,280 --> 01:56:13,520
PHASE, DOESN'T EXIST, IN DRAFT

3178
01:56:13,520 --> 01:56:14,480
FORM.

3179
01:56:14,480 --> 01:56:17,320
T IT IS BEING PROPOSED AS NOT

3180
01:56:17,320 --> 01:56:21,600
CALLING AN INSTITUTE, IT WON'T

3181
01:56:21,600 --> 01:56:22,680
BE LOCATED WITHIN THE OD.

3182
01:56:22,680 --> 01:56:27,480
I LIKE TO REFER TO IT AS ARPA H

3183
01:56:27,480 --> 01:56:28,680
BECAUSE IT IS UNIQUE.

3184
01:56:28,680 --> 01:56:31,120
IT IS DIFFERENT BUT IT WOULD BE

3185
01:56:31,120 --> 01:56:34,240
AT SIMILAR LEVEL AS AN IC.

3186
01:56:34,240 --> 01:56:37,320
I DON'T THINK WE HAVE TO WORRY

3187
01:56:37,320 --> 01:56:43,560
AT ALL KIND OF THE ISSUE OF

3188
01:56:43,560 --> 01:56:47,240
RESTRUCTURING NIH TO ACCOUNT FOR

3189
01:56:47,240 --> 01:56:50,120
THAT CAP, THAT IS SOMETHING THAT

3190
01:56:50,120 --> 01:56:52,080
WILL BE ADDRESSED AS NEEDED

3191
01:56:52,080 --> 01:56:54,920
WITHIN THE AUTHORIZING LANGUAGE

3192
01:56:54,920 --> 01:56:59,320
AND TO YOUR LAST POINT ABOUT THE

3193
01:56:59,320 --> 01:57:02,720
SYNERGIES AND COMMONALITIES OF

3194
01:57:02,720 --> 01:57:07,000
ARPA H COUPLE OF THINGS TO POINT

3195
01:57:07,000 --> 01:57:08,840
OUT, ARPA H DOES NOT INTEND TO

3196
01:57:08,840 --> 01:57:10,720
HAVE AN INTRAMURAL PROGRAM, SO

3197
01:57:10,720 --> 01:57:13,920
ONE THING THAT WILL MAKE IT

3198
01:57:13,920 --> 01:57:16,480
SOMEWHAT DISTINCT.

3199
01:57:16,480 --> 01:57:19,520
AMONG THE INSTITUTES AND

3200
01:57:19,520 --> 01:57:19,920
CENTERS.

3201
01:57:19,920 --> 01:57:22,120
BUT ALSO WHAT WE ARE TALKING

3202
01:57:22,120 --> 01:57:26,560
ABOUT HERE TOO IS LEVERAGING

3203
01:57:26,560 --> 01:57:28,560
DIFFERENT APPROACH AND MIND SET

3204
01:57:28,560 --> 01:57:30,920
TO FUNDING BIOMEDICAL RESEARCH,

3205
01:57:30,920 --> 01:57:35,000
THAT DRPA OR ARPA MODEL IF YOU

3206
01:57:35,000 --> 01:57:37,560
WILL AND WHILE I DO THINK THERE

3207
01:57:37,560 --> 01:57:41,120
ARE ELEMENTS THAT I THINK RING

3208
01:57:41,120 --> 01:57:42,880
TRUE AND PROBABLY SOUND SOMEWHAT

3209
01:57:42,880 --> 01:57:45,120
FAMILIAR FROM AN NCATS SIDE

3210
01:57:45,120 --> 01:57:47,600
THERE ARE DISTINCT DIFFERENCES

3211
01:57:47,600 --> 01:57:49,720
AND IT IS SOMETHING JONI AND I

3212
01:57:49,720 --> 01:57:52,600
TALK ABOUT HOW TO ENSURE THE

3213
01:57:52,600 --> 01:57:54,840
DISTINCTION AND THE COORDINATION

3214
01:57:54,840 --> 01:57:58,280
BETWEEN NCATS AND ARPA H THERE

3215
01:57:58,280 --> 01:58:00,280
AND AGAIN WE WANT THIS TO BE

3216
01:58:00,280 --> 01:58:02,120
COMPLIMENTARY SO WE ARE BUILDING

3217
01:58:02,120 --> 01:58:06,040
OFF THE DIFFERENT EFFORTS THAT

3218
01:58:06,040 --> 01:58:07,360
NOT JUST NCATS BUT ALL THE

3219
01:58:07,360 --> 01:58:11,320
ICs.

3220
01:58:11,320 --> 01:58:14,320
>> MAY I ASK A FOLLOW UP

3221
01:58:14,320 --> 01:58:16,080
QUESTION?

3222
01:58:16,080 --> 01:58:18,000
>> KELLY WILL HAVE THE LAST

3223
01:58:18,000 --> 01:58:18,400
WORD.

3224
01:58:18,400 --> 01:58:21,000
GO AHEAD.

3225
01:58:21,000 --> 01:58:24,240
>> I GUESS IF I HAIR YOU TALKING

3226
01:58:24,240 --> 01:58:26,920
ABOUT THAT HOW NCATS, MAYBE I'M

3227
01:58:26,920 --> 01:58:27,920
JUST TOO USED TO THINKING

3228
01:58:27,920 --> 01:58:32,640
STRUCTURE AND HOW THEY WORK.

3229
01:58:32,640 --> 01:58:34,880
JUST AS BARTA COULD BE PART OF

3230
01:58:34,880 --> 01:58:36,600
NIH BUT IT ISN'T.

3231
01:58:36,600 --> 01:58:38,880
GIVEN WHAT IT DOES.

3232
01:58:38,880 --> 01:58:40,800
IF YOU ARE GOING TO DO THIS WHY

3233
01:58:40,800 --> 01:58:43,280
NOT SET IT UP UNDER HHS AS

3234
01:58:43,280 --> 01:58:47,120
ANOTHER AGENCY EQUAL TO NIH

3235
01:58:47,120 --> 01:58:50,680
RATHERTHER HAHN SUBSUMING NIH,

3236
01:58:50,680 --> 01:58:52,320
NOT SURE WHAT -- YOU WANT A

3237
01:58:52,320 --> 01:58:54,120
DIFFERENT CULTURE, YOU WANT

3238
01:58:54,120 --> 01:58:54,800
SOMETHING DIFFERENT PRESUMABLY

3239
01:58:54,800 --> 01:58:57,080
NOT GOING TO PUT ON THE THE SAME

3240
01:58:57,080 --> 01:58:58,400
CAMPUS SAME BUILDINGS,

3241
01:58:58,400 --> 01:59:00,240
SUFFICIENTLY DIFFERENTLY SO WHY

3242
01:59:00,240 --> 01:59:02,360
SHORN IT?

3243
01:59:02,360 --> 01:59:05,920
>> SHOE HORN IT?

3244
01:59:05,920 --> 01:59:11,920
>> THREE REASONS, IT FITS WELL

3245
01:59:11,920 --> 01:59:13,960
WITH NIH.

3246
01:59:13,960 --> 01:59:17,240
THE MISSION OF ARPA H FITS WELL

3247
01:59:17,240 --> 01:59:18,600
AND SQUARELY WITHIN THE MISSION

3248
01:59:18,600 --> 01:59:19,080
OF NIH.

3249
01:59:19,080 --> 01:59:24,080
SO THAT'S ONE POINT.

3250
01:59:24,080 --> 01:59:28,200
THE SECOND POINT I WOULD SAY IS

3251
01:59:28,200 --> 01:59:29,400
TO LEVERAGE EXPERTISE AND

3252
01:59:29,400 --> 01:59:30,640
KNOWLEDGE THAT WE HAVE AT NIH

3253
01:59:30,640 --> 01:59:35,080
AND REALLY HELP TO FACILITATE

3254
01:59:35,080 --> 01:59:35,440
COLLABORATION.

3255
01:59:35,440 --> 01:59:41,640
THE FURTHER REMOVED YOU ARE, THE

3256
01:59:41,640 --> 01:59:42,720
HARDER TO BUILD THOSE.

3257
01:59:42,720 --> 01:59:45,720
WE HAVE SEEN INTERACTIONS WITH

3258
01:59:45,720 --> 01:59:46,320
BARTA.

3259
01:59:46,320 --> 01:59:50,240
TAKEN A LONG TIME TO GET TO

3260
01:59:50,240 --> 01:59:51,160
WHERE WE CURRENTLY ARE.

3261
01:59:51,160 --> 01:59:57,320
THE THIRD POINT IS MAYBE THE

3262
01:59:57,320 --> 01:59:59,480
MOST PRACTICAL.

3263
01:59:59,480 --> 02:00:01,920
THAT IS THAT WE -- STARTING THIS

3264
02:00:01,920 --> 02:00:05,480
WITHIN AN EXISTING ORGANIZATION

3265
02:00:05,480 --> 02:00:08,120
LIKE NIH ALLOW US TO LEVERAGE

3266
02:00:08,120 --> 02:00:08,920
INFRASTRUCTURE THAT EXISTS AND

3267
02:00:08,920 --> 02:00:13,560
WHAT I MEAN BY THAT, IS THE IT

3268
02:00:13,560 --> 02:00:17,520
NETWORKS, AGREEMENTS AROUND

3269
02:00:17,520 --> 02:00:20,320
GETTING SPACE AND REALLY JUST

3270
02:00:20,320 --> 02:00:21,560
PRACTICAL THINGS THAT ALLOW US

3271
02:00:21,560 --> 02:00:24,520
TO GET UP AND RUNNING IN A MUCH

3272
02:00:24,520 --> 02:00:26,240
QUICKER TIME FRAME THAN IF WE

3273
02:00:26,240 --> 02:00:27,600
HAD TO START COMPLETELY FROM

3274
02:00:27,600 --> 02:00:29,080
SCRATCH AS A NEW ORGANIZATION

3275
02:00:29,080 --> 02:00:31,120
WITHIN HHS.

3276
02:00:31,120 --> 02:00:34,640
IT WOULD SET US BACK YEARS.

3277
02:00:34,640 --> 02:00:37,120
>> I HAVE ONE OTHER QUESTION BUT

3278
02:00:37,120 --> 02:00:38,240
WILL LET KELLY GO FIRST.

3279
02:00:38,240 --> 02:00:39,320
>> WE COULD PROBABLY TALK ALL

3280
02:00:39,320 --> 02:00:39,760
DAY.

3281
02:00:39,760 --> 02:00:41,840
>> WE PROBABLY COULD.

3282
02:00:41,840 --> 02:00:44,120
IN EX TIME WE'LL HAVE MORE TIME

3283
02:00:44,120 --> 02:00:44,880
FOR YOU.

3284
02:00:44,880 --> 02:00:48,120
>> THANK YOU, TARA, THAT IS A

3285
02:00:48,120 --> 02:00:49,160
NICE PRESENTATION AND EVERYBODY

3286
02:00:49,160 --> 02:00:51,440
LIKES TO HEAR THE IDEA OF MORE

3287
02:00:51,440 --> 02:00:53,280
SPEED MORE URGENCY AND MORE

3288
02:00:53,280 --> 02:00:56,040
IMPORTANTLY MORE BUDGET TO FOCUS

3289
02:00:56,040 --> 02:00:58,520
ON BETTER HEALTH AND THE SIDE OF

3290
02:00:58,520 --> 02:01:00,640
THIS THAT IS ALSO ABOUT GLOBAL

3291
02:01:00,640 --> 02:01:04,800
COMPETITION FOR THE US.  YOU

3292
02:01:04,800 --> 02:01:06,000
JUST STARTED GOING DOWN A PATH

3293
02:01:06,000 --> 02:01:07,920
AND I THOUGHT OH I CAN RETRACT

3294
02:01:07,920 --> 02:01:09,200
MY QUESTION I DON'T NEED TO ASK

3295
02:01:09,200 --> 02:01:11,040
BECAUSE YOU SAID THE PRACTICAL

3296
02:01:11,040 --> 02:01:15,680
REASON IS REALLY ABOUT SHARED

3297
02:01:15,680 --> 02:01:18,120
INFRASTRUCTURE.

3298
02:01:18,120 --> 02:01:20,520
I WONDER WHAT REDUNDANCIES WILL

3299
02:01:20,520 --> 02:01:24,560
BE MANAGED BY ARPA H WHEN YOU

3300
02:01:24,560 --> 02:01:27,720
START TO THINK THE BREAK THROUGH

3301
02:01:27,720 --> 02:01:28,520
INFRASTRUCTURE ALL THE WORDS

3302
02:01:28,520 --> 02:01:31,000
THAT YOU USE TALKING ABOUT THE

3303
02:01:31,000 --> 02:01:33,920
PLATFORM FOCUS PARTNERSHIPS AND

3304
02:01:33,920 --> 02:01:36,720
COLLABORATIONS, I REALLY WAITING

3305
02:01:36,720 --> 02:01:40,640
TO HEAR WHAT IS GOING TO BE

3306
02:01:40,640 --> 02:01:42,320
REALLY DIFFERENT I FEEL LIKE

3307
02:01:42,320 --> 02:01:44,240
NCATS DOES ALL OF THAT AND I

3308
02:01:44,240 --> 02:01:46,320
THINK THE BREAK THROUGH

3309
02:01:46,320 --> 02:01:47,000
INFRASTRUCTURE THEY HAVE IN

3310
02:01:47,000 --> 02:01:48,160
PLACE AND I DON'T THINK THAT

3311
02:01:48,160 --> 02:01:49,960
THAT IS A TERM USED ANYWHERE BUT

3312
02:01:49,960 --> 02:01:51,520
THAT IS SORT OF WHAT HAS BEEN

3313
02:01:51,520 --> 02:01:54,120
SET UP OVER THE PAST DECADE,

3314
02:01:54,120 --> 02:01:57,120
WILL THAT BE LEVERAGED, THERE

3315
02:01:57,120 --> 02:01:58,720
WILL BE RECONDITION DANCIES IF

3316
02:01:58,720 --> 02:02:01,320
IT IS GOING TO NOT INCLUDE

3317
02:02:01,320 --> 02:02:02,320
INTRAMURAL RESEARCH WILL

3318
02:02:02,320 --> 02:02:03,920
EXTERNAL PEOPLE WORK AND

3319
02:02:03,920 --> 02:02:05,240
COLLABORATE TO HAVE ACCESS TO

3320
02:02:05,240 --> 02:02:06,480
SOME OF THESE RESOURCES THIS

3321
02:02:06,480 --> 02:02:07,320
INFRASTRUCTURE THAT DOESN'T

3322
02:02:07,320 --> 02:02:08,720
EXIST ANY PLACE ELSE IN THE

3323
02:02:08,720 --> 02:02:10,920
WORLD EXCEPT BIG PHARMA.

3324
02:02:10,920 --> 02:02:11,720
COULD YOU COMMENT ON THAT A

3325
02:02:11,720 --> 02:02:13,120
LITTLE BIT?

3326
02:02:13,120 --> 02:02:16,640
THAT GETS INTO SOME OF THE

3327
02:02:16,640 --> 02:02:17,440
PRACTICAL BRASS TAX THAT HAS NOT

3328
02:02:17,440 --> 02:02:20,360
BECOME CLEAR TO ME YET.

3329
02:02:20,360 --> 02:02:22,360
>> I THINK EVERYTHING YOU JUST

3330
02:02:22,360 --> 02:02:26,720
LAID OUT IS ABSOLUTELY CORRECT.

3331
02:02:26,720 --> 02:02:28,640
THE LEVERAGING THE

3332
02:02:28,640 --> 02:02:30,240
INFRASTRUCTURE THAT EXISTS HERE

3333
02:02:30,240 --> 02:02:33,960
IS GOING TO BE A KEY ELEMENT OF

3334
02:02:33,960 --> 02:02:34,920
ARPA H.

3335
02:02:34,920 --> 02:02:37,560
I THINK THAT WE WOULD EXPAND

3336
02:02:37,560 --> 02:02:39,080
THAT EVEN FURTHER TO TALK ABOUT

3337
02:02:39,080 --> 02:02:40,200
SOME OF THE INFRASTRUCTURE THAT

3338
02:02:40,200 --> 02:02:42,120
EXISTS ACROSS THE FEDERAL

3339
02:02:42,120 --> 02:02:43,280
GOVERNMENT BECAUSE I THINK THERE

3340
02:02:43,280 --> 02:02:47,440
IS A WHOLE LOT MORE WE COULD DO

3341
02:02:47,440 --> 02:02:53,560
IN OPERATING IN SORT OF MUCH

3342
02:02:53,560 --> 02:02:56,200
BETTER COORDINATION AS A WHOLE.

3343
02:02:56,200 --> 02:02:58,080
EXACTLY WHAT YOU SAID, THE IDEA

3344
02:02:58,080 --> 02:03:01,400
IS IS THAT WE WOULDN'T BE

3345
02:03:01,400 --> 02:03:03,240
SETTING UP OUR OWN CLINICAL

3346
02:03:03,240 --> 02:03:06,440
TRIAL NETWORKS OR OTHER THINGS

3347
02:03:06,440 --> 02:03:07,600
THAT ALREADY EXIST WITHIN NIH

3348
02:03:07,600 --> 02:03:11,920
BUT RATHER I VIEW IT AS A

3349
02:03:11,920 --> 02:03:13,960
FEEDBACK LOOP.

3350
02:03:13,960 --> 02:03:16,080
MAYBE EXAMPLE THIS IS NOT

3351
02:03:16,080 --> 02:03:20,640
LIMITING BUT SOME OF THE REALLY

3352
02:03:20,640 --> 02:03:21,760
INTERESTING AND EXCITING

3353
02:03:21,760 --> 02:03:22,960
FUNDAMENTAL BASIC RESEARCH

3354
02:03:22,960 --> 02:03:26,520
THAT'S COMING OUT OF THE

3355
02:03:26,520 --> 02:03:29,320
INSTITUTES FEEDS INTO OR ALLOWS

3356
02:03:29,320 --> 02:03:35,720
FOR THE IDEA ARPA H HAS TO MOVE

3357
02:03:35,720 --> 02:03:39,760
FORWARD AND MAKE STRIDES AND

3358
02:03:39,760 --> 02:03:40,800
ADVANCEMENTS AND THEN MAYBE YOU

3359
02:03:40,800 --> 02:03:42,600
TAKE THAT AND GET THAT TO PROOF

3360
02:03:42,600 --> 02:03:44,920
OF CONCEPT STAGE, AND YOU

3361
02:03:44,920 --> 02:03:48,160
LEVERAGE AN ICs CLINICAL TRIAL

3362
02:03:48,160 --> 02:03:52,600
NETWORK AND WORK WITH FDA AND

3363
02:03:52,600 --> 02:03:54,080
CMS AND OTHERS ACROSS THE

3364
02:03:54,080 --> 02:03:55,560
FEDERAL GOVERNMENT TO MOVE THAT

3365
02:03:55,560 --> 02:03:57,200
FORWARD IN A ROBUST WAY.

3366
02:03:57,200 --> 02:03:58,240
THERE MIGHT BE THEN AN

3367
02:03:58,240 --> 02:04:00,480
OPPORTUNITY AT THE END TO

3368
02:04:00,480 --> 02:04:01,920
OBVIOUSLY THEN HAVE ANOTHER

3369
02:04:01,920 --> 02:04:04,360
MAYBE EVEN ARPA H PROJECT WHERE

3370
02:04:04,360 --> 02:04:07,120
WHAT DOES THAT LOOK LIKE TO

3371
02:04:07,120 --> 02:04:10,360
ADDRESS SOME MAYBE LARGE SCALE

3372
02:04:10,360 --> 02:04:12,560
NATIONAL CHALLENGES TOWARDS

3373
02:04:12,560 --> 02:04:12,960
IMPLEMENTATION.

3374
02:04:12,960 --> 02:04:14,320
I THINK THE OTHER THING TO POINT

3375
02:04:14,320 --> 02:04:16,320
OUT TOO IS THAT WITH ARPA H WHAT

3376
02:04:16,320 --> 02:04:17,720
WE ARE TALKING ABOUT IS

3377
02:04:17,720 --> 02:04:18,720
BIOMEDICAL AND HEALTH RESEARCH,

3378
02:04:18,720 --> 02:04:22,080
WE USE THAT TERMINOLOGY REALLY

3379
02:04:22,080 --> 02:04:25,520
BROADLY BECAUSE WE SORT OF VIEW

3380
02:04:25,520 --> 02:04:27,400
IT FROM REALLY LARGE SPECTRUM OF

3381
02:04:27,400 --> 02:04:29,800
THE TYPE OF RESEARCH THIS WILL

3382
02:04:29,800 --> 02:04:33,680
SUPPORT AND GET INTO

3383
02:04:33,680 --> 02:04:35,560
IMPLEMENTATION AND DISSEMINATION

3384
02:04:35,560 --> 02:04:36,720
AND HOW THESE THINGS GET OUT TO

3385
02:04:36,720 --> 02:04:41,920
PATIENTS.

3386
02:04:41,920 --> 02:04:43,920
>> THANK YOU.

3387
02:04:43,920 --> 02:04:45,240
>> LAST QUESTION OR IMMEDIATE TO

3388
02:04:45,240 --> 02:04:45,880
CLOSE OUT?

3389
02:04:45,880 --> 02:04:47,440
>> WE NEED TO CLOSE OUT.

3390
02:04:47,440 --> 02:04:51,120
GO AHEAD, ASK YOUR QUESTION

3391
02:04:51,120 --> 02:04:51,600
PLEASE.

3392
02:04:51,600 --> 02:04:55,400
>> I WANT TO COME TO MONEY.

3393
02:04:55,400 --> 02:04:57,400
SO YOU ARE MAKING THIS ASK IN

3394
02:04:57,400 --> 02:04:58,440
THE BUDGET WHATEVER THE NUMBERS

3395
02:04:58,440 --> 02:05:01,240
YOU SAID WHETHER IT IS WE HEARD

3396
02:05:01,240 --> 02:05:03,720
DIFFERENT NUMBERS THROWN AROUND,

3397
02:05:03,720 --> 02:05:05,120
3 BILLION, 6 BILLION WHATEVER

3398
02:05:05,120 --> 02:05:06,040
THAT MIGHT BE.

3399
02:05:06,040 --> 02:05:07,760
HARKENING BACK TO EXPERIENCE

3400
02:05:07,760 --> 02:05:12,040
STARTING N CATS AND WHAT WE GOT

3401
02:05:12,040 --> 02:05:13,080
INITIALLY AND HOW WE GET IT TO

3402
02:05:13,080 --> 02:05:14,920
THE POINT AND ONE OF THE THINGS

3403
02:05:14,920 --> 02:05:16,360
THAT WAS A THIRD RAIL IN THE

3404
02:05:16,360 --> 02:05:17,840
ORGANIZATION WHEN NCATS WAS

3405
02:05:17,840 --> 02:05:20,760
STOOD UP IS THE IDEA THAT HE PUT

3406
02:05:20,760 --> 02:05:22,880
IN ANY WAY CANNIBALIZE ANY OTHER

3407
02:05:22,880 --> 02:05:24,080
IC BUDGET SO IN A SENSE THAT

3408
02:05:24,080 --> 02:05:26,960
THERE IS A ZERO SUM CONCERN THAT

3409
02:05:26,960 --> 02:05:28,920
THIS HAD TO BE NEW MONEY HA

3410
02:05:28,920 --> 02:05:31,920
COMES IN TO DO THIS.

3411
02:05:31,920 --> 02:05:33,520
SO ARE WE SAYING THAT THAT IS

3412
02:05:33,520 --> 02:05:35,320
WHAT REALLY IS GOING TO HAPPEN

3413
02:05:35,320 --> 02:05:37,400
WITH THE POLITICAL CLIMATE

3414
02:05:37,400 --> 02:05:38,880
CERTAINLY SUPPORT ONE FIFTH OF

3415
02:05:38,880 --> 02:05:40,880
THE NIH BUDGET TO BE ARPA H,

3416
02:05:40,880 --> 02:05:42,240
THAT'S THE SIZE OF ESSENTIALLY

3417
02:05:42,240 --> 02:05:45,920
THE LARGEST INSTITUTE LIKE NCI

3418
02:05:45,920 --> 02:05:47,600
AND NIAID WOULD BE STOOD UP FROM

3419
02:05:47,600 --> 02:05:49,280
THE GET GO.

3420
02:05:49,280 --> 02:05:53,880
>> I MEAN IF YOU -- LOOK AT THE

3421
02:05:53,880 --> 02:05:56,520
DRAFT LEGISLATION, IT IS ALL

3422
02:05:56,520 --> 02:05:59,320
DRAFT LANGUAGE IN TERMS OF

3423
02:05:59,320 --> 02:06:00,440
APPROPRIATION.

3424
02:06:00,440 --> 02:06:02,320
IT IS NEW MONEY, IT IS NOT

3425
02:06:02,320 --> 02:06:03,880
CANNIBALIZING FROM THE NIH

3426
02:06:03,880 --> 02:06:04,240
BUDGET.

3427
02:06:04,240 --> 02:06:06,040
WE WOULD NOT ADVOCATE FOR THAT

3428
02:06:06,040 --> 02:06:09,720
IN FACT WE DIDN'T, WE NAVIGATED

3429
02:06:09,720 --> 02:06:11,560
HARD THAT THAT SHOULDN'T BE THE

3430
02:06:11,560 --> 02:06:11,880
CASE.

3431
02:06:11,880 --> 02:06:14,280
IF FACT I THINK BOTH THE HOUSE

3432
02:06:14,280 --> 02:06:15,720
AND SENATE GAVE THE NIH

3433
02:06:15,720 --> 02:06:18,240
INCREASES ON TOP OF THE FY 21

3434
02:06:18,240 --> 02:06:19,840
BUDGET FOR FY 22.

3435
02:06:19,840 --> 02:06:21,640
THIS IS ALL DRAFT LANGUAGE,

3436
02:06:21,640 --> 02:06:24,360
NOTHING HAS BEEN PASSED YET.

3437
02:06:24,360 --> 02:06:26,200
>> THANKS, THAT WAS TERRIFIC.

3438
02:06:26,200 --> 02:06:28,120
YOU EXPERTLY ANSWERED A LOT OF

3439
02:06:28,120 --> 02:06:29,040
QUESTIONS AND WE REALLY

3440
02:06:29,040 --> 02:06:29,840
APPRECIATE YOUR TIME HERE.

3441
02:06:29,840 --> 02:06:32,120
THANK YOU FOR THE PRESENTATION.

3442
02:06:32,120 --> 02:06:35,240
WE LOOK FORWARD TO SAYING ALONG

3443
02:06:35,240 --> 02:06:36,880
WITH YOU HOW WE UPHOLD THIS

3444
02:06:36,880 --> 02:06:38,600
GOING FORWARD AND HOPEFULLY WE

3445
02:06:38,600 --> 02:06:42,040
CAN HAVE THIS BACK SOON AT

3446
02:06:42,040 --> 02:06:42,280
COUNCIL.

3447
02:06:42,280 --> 02:06:43,600
>> I APPRECIATE COPY OF THAT

3448
02:06:43,600 --> 02:06:44,720
REPORT MENTIONED AT THE

3449
02:06:44,720 --> 02:06:45,760
BEGINNING, WOULD LOVE TO SEE

3450
02:06:45,760 --> 02:06:47,560
THAT.

3451
02:06:47,560 --> 02:06:49,240
THANK YOU FOR INVITING ME.

3452
02:06:49,240 --> 02:06:51,400
APPRECIATE THE ROBUST DISCUSSION

3453
02:06:51,400 --> 02:06:53,640
AND I'M ASSURE JONI YOU AND I

3454
02:06:53,640 --> 02:06:57,200
WILL TALK AGAIN.

3455
02:06:57,200 --> 02:06:57,520
TAKE CARE.

3456
02:06:57,520 --> 02:07:00,080
>> THANK YOU.

3457
02:07:00,080 --> 02:07:01,240
>> THANK YOU SO MUCH.

3458
02:07:01,240 --> 02:07:02,800
WITH THAT WE DID GET A LITTLE

3459
02:07:02,800 --> 02:07:05,080
OVER IN TIME SO HOPE WE CAN MAKE

3460
02:07:05,080 --> 02:07:06,520
UP FOR THAT IN THE NEXT COUPLE

3461
02:07:06,520 --> 02:07:07,560
OF PRESENTATIONS.

3462
02:07:07,560 --> 02:07:10,160
BUT WE ARE GOING TO MOVE ON TO

3463
02:07:10,160 --> 02:07:12,000
LILY PORTILLA I BELIEVE IS NEXT

3464
02:07:12,000 --> 02:07:13,280
TO TALK ABOUT THE OFFICE OF

3465
02:07:13,280 --> 02:07:14,720
STRATEGIC ALLIANCE.

3466
02:07:14,720 --> 02:07:18,800
SO LILY PLEASE GO AHEAD.

3467
02:07:18,800 --> 02:07:20,880
>> CAN YOU HEAR ME?

3468
02:07:20,880 --> 02:07:21,320
>> YEP.

3469
02:07:21,320 --> 02:07:23,920
>> GREAT.

3470
02:07:23,920 --> 02:07:26,320
HI, I'M LILY PORTILLA, DIRECTOR

3471
02:07:26,320 --> 02:07:28,080
OF STRATEGIC ALLIANCES AT NCATS

3472
02:07:28,080 --> 02:07:31,320
AND JUST TO ORIENT TO COUNCIL

3473
02:07:31,320 --> 02:07:33,520
OUR OFFICE IS IN CHARGE OF ALL

3474
02:07:33,520 --> 02:07:37,880
THE AGREEMENT AND PARTNERSHIP

3475
02:07:37,880 --> 02:07:39,880
ESTABLISHMENTS THAT GO ON ACROSS

3476
02:07:39,880 --> 02:07:42,080
THE CENTER, THE OTHER THING WE

3477
02:07:42,080 --> 02:07:45,400
DO IS ALSO RUN THE SBIR STTR

3478
02:07:45,400 --> 02:07:48,160
PROGRAM AND THE FOCUS OF MY

3479
02:07:48,160 --> 02:07:49,120
CONVERSATION TODAY OR MY

3480
02:07:49,120 --> 02:07:50,760
PRESENTATION TODAY IS GOING TO

3481
02:07:50,760 --> 02:07:54,800
BE ON THE SBR STTR PROGRAM AND

3482
02:07:54,800 --> 02:07:57,720
OUR EFFORTS AROUND THAT SPECIFIC

3483
02:07:57,720 --> 02:08:00,240
PROGRAM, WITH THAT I WILL START.

3484
02:08:00,240 --> 02:08:04,520
NEXT SLIDE PLEASE.

3485
02:08:04,520 --> 02:08:07,400
SO THE NIH SBIR STTR PROGRAMS

3486
02:08:07,400 --> 02:08:09,120
LARGEST SOURCES OF EARLY STAGE

3487
02:08:09,120 --> 02:08:13,000
SEED FUNDING IN THE COUNTRY.

3488
02:08:13,000 --> 02:08:15,320
BUDGET IS WELL OVER A BILLION

3489
02:08:15,320 --> 02:08:16,960
DOLLARS NOW THAT ACROSS THE NIH

3490
02:08:16,960 --> 02:08:20,640
THAT HAS TO GO TO U.S. SMALL

3491
02:08:20,640 --> 02:08:24,920
BUSINESSES WORKING IN THE

3492
02:08:24,920 --> 02:08:26,880
BIOMEDICAL SPACE AND 24

3493
02:08:26,880 --> 02:08:31,040
INSTITUTES INCLUDING NCATS HAVE

3494
02:08:31,040 --> 02:08:33,080
BUDGETS THAT SUPPORT THE SBIR

3495
02:08:33,080 --> 02:08:34,520
STTR PROGRAM.

3496
02:08:34,520 --> 02:08:40,160
IT IS A 3.65% SET ASIDE, IT IS A

3497
02:08:40,160 --> 02:08:41,520
CONGRESSIONALLY MANDATED

3498
02:08:41,520 --> 02:08:42,800
PROGRAM, IT IS NOT MONEY THAT

3499
02:08:42,800 --> 02:08:45,320
CAN BE REPROGRAMMED TO OTHER

3500
02:08:45,320 --> 02:08:47,640
GRANT LINES OR CONTRACT LINES,

3501
02:08:47,640 --> 02:08:51,640
IT HAS TO BE USED IN SUPPORT OF

3502
02:08:51,640 --> 02:08:52,880
U.S. SMALL BUSINESS.

3503
02:08:52,880 --> 02:08:56,160
LET'S GO TO NEXT SLIDE.

3504
02:08:56,160 --> 02:09:02,640
LET'S CLICK ONE MORE TIME.

3505
02:09:02,640 --> 02:09:03,880
MAJORITY OF APPLICATIONS THREE

3506
02:09:03,880 --> 02:09:05,320
WAYS APPLICATIONS COME IN FOR

3507
02:09:05,320 --> 02:09:05,920
THIS PROGRAM.

3508
02:09:05,920 --> 02:09:07,320
THE MAJORITY OF THE APPLICATIONS

3509
02:09:07,320 --> 02:09:10,160
COME IN WHAT'S CALLED THE

3510
02:09:10,160 --> 02:09:12,520
OMNIBUS THAT IS 24 PARTICIPATING

3511
02:09:12,520 --> 02:09:14,000
INSTITUTES UTILIZES WELL AS OUR

3512
02:09:14,000 --> 02:09:16,760
SISTER AGENCIES AT THE CDC AND

3513
02:09:16,760 --> 02:09:20,240
FDA, OTHER PARTS OF HHS.

3514
02:09:20,240 --> 02:09:22,720
I WOULD SAY ABOUT 90%

3515
02:09:22,720 --> 02:09:24,040
APPLICATIONS THAT WE GET IN ARE

3516
02:09:24,040 --> 02:09:26,720
FUNDED THROUGH THE OMNIBUS WHICH

3517
02:09:26,720 --> 02:09:30,240
IS BROAD TOPICS ACROSS THE NIH

3518
02:09:30,240 --> 02:09:32,680
NCATS HAS LISTED THOSE RESEARCH

3519
02:09:32,680 --> 02:09:34,360
PRIORITIES AS PART OF THE

3520
02:09:34,360 --> 02:09:36,520
OMNIBUS SOLICITATION.

3521
02:09:36,520 --> 02:09:38,000
THE OTHER WAY WE GET

3522
02:09:38,000 --> 02:09:39,240
APPLICATIONS IS LIEU TARGETED

3523
02:09:39,240 --> 02:09:40,720
SOLICITATION, WE HAVE A FEW OF

3524
02:09:40,720 --> 02:09:43,120
THEM WE GENERATED HERE AT N

3525
02:09:43,120 --> 02:09:46,480
CATS, WE ALSO PARTICIPATE IN

3526
02:09:46,480 --> 02:09:47,360
SOLICITATION OTHER INSTITUTES

3527
02:09:47,360 --> 02:09:50,040
HAVE PUT TOGETHER.

3528
02:09:50,040 --> 02:09:52,720
ONCE A YEAR THERE IS A CONTRACT

3529
02:09:52,720 --> 02:09:55,560
SOLICITATION AND THIS IS WHEN

3530
02:09:55,560 --> 02:09:56,920
SPECIFIC DELIVERABLE -- WE

3531
02:09:56,920 --> 02:09:58,520
BELIEVE A SPECIFIC DELIVERABLE

3532
02:09:58,520 --> 02:10:00,080
CAN BE TARGETED BY SMALL

3533
02:10:00,080 --> 02:10:01,120
BUSINESS AND I WANT TO CLARIFY

3534
02:10:01,120 --> 02:10:02,560
THAT IT IS NOT LIKE A SERVICE,

3535
02:10:02,560 --> 02:10:03,920
WE ARE NOT ASKING FOR A SERVICE

3536
02:10:03,920 --> 02:10:05,280
TO BE PROVIDED BY A SMALL

3537
02:10:05,280 --> 02:10:06,600
BUSINESS BUT WE ARE SAYING THAT

3538
02:10:06,600 --> 02:10:13,480
WE THINK THERE'S A TECHNOLOGY

3539
02:10:13,480 --> 02:10:14,400
SOLUTION PROVIDED BY SMALL

3540
02:10:14,400 --> 02:10:15,160
BUSINESS AND THE CONTRACT

3541
02:10:15,160 --> 02:10:18,240
MECHANISM WHICH HAPPENS ONCE A

3542
02:10:18,240 --> 02:10:22,720
YEAR, IS BEST WAY THE GET THOSE,

3543
02:10:22,720 --> 02:10:24,320
WE BROAD THOSE TO YOU ALL AND

3544
02:10:24,320 --> 02:10:30,400
COUNCIL THE APPROVE.

3545
02:10:30,400 --> 02:10:32,520
SBIR STTR HAS SEVERAL BENEFITS

3546
02:10:32,520 --> 02:10:35,120
AS I MENTIONED LEAD TO OVERALL

3547
02:10:35,120 --> 02:10:36,960
BUDGET SO IT IS STABLE AND

3548
02:10:36,960 --> 02:10:40,320
PREDICTABLE,IT IS NON-DILUTIVE.

3549
02:10:40,320 --> 02:10:43,000
THE GOVERNMENT DOESN'T TAKE IP

3550
02:10:43,000 --> 02:10:44,800
RIGHTS DEVELOPED UNDER THIS

3551
02:10:44,800 --> 02:10:45,200
PROGRAM.

3552
02:10:45,200 --> 02:10:47,000
ONCE IN THE PROGRAM, ONCE YOU

3553
02:10:47,000 --> 02:10:49,040
RECEIVE A GRANT YOU GET ACCESS

3554
02:10:49,040 --> 02:10:52,800
TO SOME TECHNICAL ASSISTANCE AND

3555
02:10:52,800 --> 02:10:54,240
COMMERCIALIZATION PROGRAMS THAT

3556
02:10:54,240 --> 02:10:59,440
THE NIH OFFERS ALONGSIDE OF WITH

3557
02:10:59,440 --> 02:11:03,440
THE GRANT WE FOR EXAMPLE OFFER

3558
02:11:03,440 --> 02:11:04,320
COMPANIES OPPORTUNITY TO GO

3559
02:11:04,320 --> 02:11:05,680
THROUGH INNOVATION CORE TRAINING

3560
02:11:05,680 --> 02:11:06,040
PROGRAM.

3561
02:11:06,040 --> 02:11:09,080
WE WILL PAY FOR THEM TO DO THAT.

3562
02:11:09,080 --> 02:11:12,840
WE ALSO NIH HOST IN LARGE

3563
02:11:12,840 --> 02:11:15,600
CONFERENCES LIKE BIO AND ABMED

3564
02:11:15,600 --> 02:11:17,120
HAVE SPACE WHERE MANY COMPANIES

3565
02:11:17,120 --> 02:11:19,920
CAN DO PITCHES TO POTENTIAL

3566
02:11:19,920 --> 02:11:21,800
INVESTORS AS WELL TOO, THAT IS

3567
02:11:21,800 --> 02:11:22,640
ANOTHER BENEFIT OF BEING IN THE

3568
02:11:22,640 --> 02:11:25,320
PROGRAM.

3569
02:11:25,320 --> 02:11:26,920
I BELIEVE I MENTIONED THAT

3570
02:11:26,920 --> 02:11:28,600
BEFORE THAT, ONE OF THE OTHER

3571
02:11:28,600 --> 02:11:31,040
BENEFITS IS THAT THE PROGRAM --

3572
02:11:31,040 --> 02:11:33,040
THE GRANTS AND CONTRACTS GO

3573
02:11:33,040 --> 02:11:35,800
THROUGH RIGOROUS PEER REVIEW

3574
02:11:35,800 --> 02:11:37,280
PROCESS, WHICH THEY CAN THEN

3575
02:11:37,280 --> 02:11:38,600
LEVERAGE FOR ADDITIONAL FUNDING

3576
02:11:38,600 --> 02:11:43,120
THROUGH OTHER SOURCES, PRIVATE

3577
02:11:43,120 --> 02:11:45,560
INVESTMENT, AND EVEN STATE

3578
02:11:45,560 --> 02:11:47,040
ECONOMIC ORGANIZATIONS HAVE

3579
02:11:47,040 --> 02:11:49,720
COMPLIMENTARY PROGRAMS ONCE YOU

3580
02:11:49,720 --> 02:11:54,000
GET AT NIH SBIR STTR.

3581
02:11:54,000 --> 02:11:57,160
IT IS THREE PHASE PROGRAM, PHASE

3582
02:11:57,160 --> 02:12:00,360
1 IS FEASIBILITY STUDIES AND

3583
02:12:00,360 --> 02:12:02,440
THERE ARE PROGRAM CAPS BUDGET

3584
02:12:02,440 --> 02:12:03,680
CAPS THAT THE NIH HAS TO ADHERE

3585
02:12:03,680 --> 02:12:05,640
TO THAT ARE SET BY THE SMALL

3586
02:12:05,640 --> 02:12:07,480
BUSINESS ADMINISTRATION.

3587
02:12:07,480 --> 02:12:09,880
HOWEVER, THERE ARE SOME TOPICS

3588
02:12:09,880 --> 02:12:12,080
ACROSS THE NIH THAT WE HAVE

3589
02:12:12,080 --> 02:12:14,120
ALLOWED HIGHER BUDGET DOLLAR

3590
02:12:14,120 --> 02:12:18,240
AMOUNTS, PHASE 2 IS MORE FULL

3591
02:12:18,240 --> 02:12:21,160
ADD PROGRAMS WE CAN GO UP TO 2

3592
02:12:21,160 --> 02:12:23,240
MILLION OVER PROJECTS THAT LAST

3593
02:12:23,240 --> 02:12:25,760
BETWEEN TWO TO THREE YEARS.

3594
02:12:25,760 --> 02:12:27,480
THE FAST TRACK THAT COMBINES

3595
02:12:27,480 --> 02:12:30,040
BOTH THE PHASE 1 AND PHASE 2 ONE

3596
02:12:30,040 --> 02:12:32,720
REVIEW THE COMPANY HAS TO GO

3597
02:12:32,720 --> 02:12:33,080
THROUGH.

3598
02:12:33,080 --> 02:12:34,880
DIRECT TO PHASE 2 WHICH ALLOWS

3599
02:12:34,880 --> 02:12:36,600
YOU TO SKIP THE PHASE 1 IF YOU

3600
02:12:36,600 --> 02:12:38,040
HAVE ENOUGH DATA YOU HAVE GOTTEN

3601
02:12:38,040 --> 02:12:40,200
UNDER FEASIBILITY STUDY.

3602
02:12:40,200 --> 02:12:42,120
AND THE PHASE 2B COMPETING

3603
02:12:42,120 --> 02:12:43,720
RENEWAL PROGRAM WE OFFER TO ONLY

3604
02:12:43,720 --> 02:12:47,200
COMPANIES THAT WE FUND IN PHASE

3605
02:12:47,200 --> 02:12:49,520
2.

3606
02:12:49,520 --> 02:12:55,760
UNLIKE OTHER AGENCIES WITH STIR

3607
02:12:55,760 --> 02:12:57,960
SBIR, WE DO NOT HAVE A PHASE 3

3608
02:12:57,960 --> 02:13:00,320
PROGRAM BUT WE PRESUME COMPANIES

3609
02:13:00,320 --> 02:13:01,120
ARE GRADUATING OUT OF THE

3610
02:13:01,120 --> 02:13:02,120
PROGRAM AND PSYCHING PRIVATE

3611
02:13:02,120 --> 02:13:05,560
SOURCES OF FUNDING, OR

3612
02:13:05,560 --> 02:13:06,720
DEVELOPING STRATEGIC

3613
02:13:06,720 --> 02:13:07,880
PARTNERSHIPS.

3614
02:13:07,880 --> 02:13:08,760
HOPEFULLY THE GRANT HAS GOT TO

3615
02:13:08,760 --> 02:13:09,920
THAT KEY INFLECTION POINT WHERE

3616
02:13:09,920 --> 02:13:14,080
THEY CAN DO THAT.

3617
02:13:14,080 --> 02:13:14,800
NEXT SLIDE.

3618
02:13:14,800 --> 02:13:18,960
THERE ARE -- I WON'T GO THROUGH

3619
02:13:18,960 --> 02:13:20,840
THE DIFFERENCES BETWEEN

3620
02:13:20,840 --> 02:13:22,280
GUIDELINE AND ELIGIBILITY

3621
02:13:22,280 --> 02:13:23,720
REQUIREMENTS BUT THERE ARE --

3622
02:13:23,720 --> 02:13:25,720
THE MAIN DIFFERENCE BETWEEN THE

3623
02:13:25,720 --> 02:13:30,320
TWO OF SBIR AND STTR IS THE STTR

3624
02:13:30,320 --> 02:13:32,400
HAS -- MUST HAVE A RESEARCH

3625
02:13:32,400 --> 02:13:34,040
INSTITUTION COMPONENT TO IT.

3626
02:13:34,040 --> 02:13:35,720
IN THAT INSTANCE THE PI CAN

3627
02:13:35,720 --> 02:13:38,280
EITHER WORK FOR THE RESEARCH

3628
02:13:38,280 --> 02:13:39,320
INSTITUTION OR CAN WORK FOR THE

3629
02:13:39,320 --> 02:13:40,000
SMALL BUSINESS.

3630
02:13:40,000 --> 02:13:42,360
BUT KEEP IN MIND THAT THE GRANT

3631
02:13:42,360 --> 02:13:46,200
ALWAYS HAS TO GO TO THE SMALL

3632
02:13:46,200 --> 02:13:47,120
BUSINESS.

3633
02:13:47,120 --> 02:13:49,920
THERE ARE WORK REQUIREMENTS

3634
02:13:49,920 --> 02:13:51,720
DIFFERENCE BETWEEN PROGRAMS NOT

3635
02:13:51,720 --> 02:13:53,040
ALL GRANT CAN BE OUTSOURCED,

3636
02:13:53,040 --> 02:13:55,640
MANY TIMES WE HAVE VIRTUAL

3637
02:13:55,640 --> 02:13:56,760
COMPANY ASKING IF THEY WANT TO

3638
02:13:56,760 --> 02:13:58,000
PARTICIPATE IN THE PROGRAM BUT

3639
02:13:58,000 --> 02:14:01,440
THERE HAS TO BE WORK DONE WITHIN

3640
02:14:01,440 --> 02:14:02,600
THAT SMALL BUSINESS IN ORDER TO

3641
02:14:02,600 --> 02:14:04,120
BE ELIGIBLE TO RECEIVE THE

3642
02:14:04,120 --> 02:14:10,520
AWARD.

3643
02:14:10,520 --> 02:14:13,160
NOW I WILL GET INTO INITIATIVES

3644
02:14:13,160 --> 02:14:14,280
AND PROGRAM CHANGES ACROSS THE

3645
02:14:14,280 --> 02:14:14,720
NIH.

3646
02:14:14,720 --> 02:14:16,040
NEXT SLIDE.

3647
02:14:16,040 --> 02:14:18,120
THERE HAVE BEEN CHANGES TO THE

3648
02:14:18,120 --> 02:14:19,600
BUDGET CAPS, THERE WAS A PERIOD

3649
02:14:19,600 --> 02:14:22,920
OF TIME THERE WHERE THE BUDGET

3650
02:14:22,920 --> 02:14:24,480
CAP STAYED STATIC OF SMALL

3651
02:14:24,480 --> 02:14:27,120
BUSINESS ADMINISTRATION OVER

3652
02:14:27,120 --> 02:14:28,560
SEVERAL YEARS HAS INCREASED THAT

3653
02:14:28,560 --> 02:14:32,120
WE ARE NOW UP TO 275 AND CHANGE

3654
02:14:32,120 --> 02:14:37,240
FOR PHASE 1 AND 1.8 MILLION FOR

3655
02:14:37,240 --> 02:14:37,600
PHASE 2.

3656
02:14:37,600 --> 02:14:40,920
THERE ARE TOPICS AT THE NIH DOES

3657
02:14:40,920 --> 02:14:42,720
ALLOW FOR HIGHER BUDGET AMOUNTS

3658
02:14:42,720 --> 02:14:44,160
AND THEY ARE CALLED WAIVER

3659
02:14:44,160 --> 02:14:44,520
TOPICS.

3660
02:14:44,520 --> 02:14:46,640
EACH INSTITUTE HAS THEIR WAIVER

3661
02:14:46,640 --> 02:14:49,240
TOPICS THAT YOU CAN APPLY UNDER

3662
02:14:49,240 --> 02:14:50,920
AND FOR US THE WAIVER TOPICS

3663
02:14:50,920 --> 02:14:54,200
ALLOW YOU TO GO UP TO 325,000

3664
02:14:54,200 --> 02:14:56,600
FOR PHASE 1.

3665
02:14:56,600 --> 02:14:57,480
2 MILLION FOR PHASE 2.

3666
02:14:57,480 --> 02:15:00,680
WE THINK THAT THAT IS WARRANTED

3667
02:15:00,680 --> 02:15:02,680
FOR SOME TOPICS BUT WE BELIEVE

3668
02:15:02,680 --> 02:15:05,480
OUR BUDGET CAN SUPPORT THESE

3669
02:15:05,480 --> 02:15:06,840
HIGHER BUDGET DOLLAR AMOUNTS.

3670
02:15:06,840 --> 02:15:10,600
NEXT SLIDE PLEASE.

3671
02:15:10,600 --> 02:15:15,600
THERE'S ALSO CHANGES AROUND

3672
02:15:15,600 --> 02:15:16,400
TECHNICAL AND BUSINESS

3673
02:15:16,400 --> 02:15:17,200
ASSISTANCE PROGRAM.

3674
02:15:17,200 --> 02:15:18,840
COMPANIES NOW REQUEST IN

3675
02:15:18,840 --> 02:15:22,120
ADDITION TO THE -- THEIR BUDGET

3676
02:15:22,120 --> 02:15:29,400
THEY CAN ASK FOR 6,500 PER YEAR

3677
02:15:29,400 --> 02:15:31,520
PHASE 1 AND 50,000 FOR PHASE 2,

3678
02:15:31,520 --> 02:15:33,560
IT WOULD ALLOW THE COMPANY TO DO

3679
02:15:33,560 --> 02:15:38,320
THINGS LIKE MARKET ANALYSIS, OF

3680
02:15:38,320 --> 02:15:39,560
TECHNOLOGY, PATENT LANDSCAPE OR

3681
02:15:39,560 --> 02:15:42,240
FILING PATENTS BUT THIS IS A NEW

3682
02:15:42,240 --> 02:15:46,880
INITIATIVE THAT IS STARTED NIH

3683
02:15:46,880 --> 02:15:51,320
OFFERS COMPANIES THAT ARE

3684
02:15:51,320 --> 02:15:54,920
INTERESTED CONSULTING SERVICES

3685
02:15:54,920 --> 02:15:57,040
TO FIGURE TECHNOLOGY TO A

3686
02:15:57,040 --> 02:15:58,240
INFLECTION POINT TO GET

3687
02:15:58,240 --> 02:15:58,960
STRATEGIC PARTNERSHIP OR

3688
02:15:58,960 --> 02:16:02,280
INVESTMENT BUT THE TECHNICAL

3689
02:16:02,280 --> 02:16:03,480
ASSISTANCE FUNDING IS VERY

3690
02:16:03,480 --> 02:16:04,400
HELPFUL IN TERMS OF DOING THAT.

3691
02:16:04,400 --> 02:16:06,000
NEXT SLIDE PLEASE.

3692
02:16:06,000 --> 02:16:08,480
I ALSO WANT TO POINT OUT THAT

3693
02:16:08,480 --> 02:16:13,560
LIKE OTHER NIH GRANT PROGRAMS

3694
02:16:13,560 --> 02:16:15,680
SBIR STTR TAKES ADMINISTRATIVE

3695
02:16:15,680 --> 02:16:17,200
SUPPLEMENTS TO PROMOTE

3696
02:16:17,200 --> 02:16:17,640
DIVERSITY.

3697
02:16:17,640 --> 02:16:19,400
IN THIS INSTANCE THE -- THIS

3698
02:16:19,400 --> 02:16:22,080
PARTICULAR ADMINISTRATIVE

3699
02:16:22,080 --> 02:16:27,320
SUPPLEMENT IS IN SUPPORT OF

3700
02:16:27,320 --> 02:16:28,520
INDIVIDUALS WHO WANT TO WORK IN

3701
02:16:28,520 --> 02:16:29,320
SMALL BUSINESS AND GET

3702
02:16:29,320 --> 02:16:31,040
EXPERIENCE AS PART OF THE C

3703
02:16:31,040 --> 02:16:33,720
SUITE OR DOING RESEARCH FOR THE

3704
02:16:33,720 --> 02:16:36,640
SMALL BUSINESS AND I WANT TO

3705
02:16:36,640 --> 02:16:38,520
NOTE THIS IS A SPECIAL

3706
02:16:38,520 --> 02:16:39,440
ADMINISTRATIVE SUPPLEMENT ONLY

3707
02:16:39,440 --> 02:16:46,200
FOR SBIR STTR COMPANIES.

3708
02:16:46,200 --> 02:16:47,760
WE ALSO PARTICIPATE WITH NINE

3709
02:16:47,760 --> 02:16:49,200
OTHER INSTITUTES IN THE

3710
02:16:49,200 --> 02:16:51,520
APPLICANT ASSISTANCE PROGRAM AND

3711
02:16:51,520 --> 02:16:53,960
HERE APPLICANTS THAT HAVE EITHER

3712
02:16:53,960 --> 02:16:58,320
NEVER APPLIED TO THE NIH OR

3713
02:16:58,320 --> 02:17:00,000
APPLIED NOT SUCCESSFUL AND GIVEN

3714
02:17:00,000 --> 02:17:07,800
A MENTOR TO WORK WITH PUTTING

3715
02:17:07,800 --> 02:17:09,040
APPLICATION TOGETHER, HONING

3716
02:17:09,040 --> 02:17:12,040
TOPICS AND THE CONSULTANT THAT

3717
02:17:12,040 --> 02:17:13,720
WORKS WITH THEM HAS A LOT OF

3718
02:17:13,720 --> 02:17:15,480
EXPERIENCE WORKING WITH --

3719
02:17:15,480 --> 02:17:16,600
HELPING COMPANIES WITH NIH

3720
02:17:16,600 --> 02:17:18,320
GRANTS AND WHAT IT DOESN'T DO,

3721
02:17:18,320 --> 02:17:19,880
IT DOESN'T WRITE THE GRANT FOR

3722
02:17:19,880 --> 02:17:23,200
THEM BUT GIVES THEM THE TOOLS

3723
02:17:23,200 --> 02:17:25,320
AND KNOWLEDGE NEEDED TO BE

3724
02:17:25,320 --> 02:17:28,320
SUCCESSFUL IN GETTING NIH

3725
02:17:28,320 --> 02:17:28,880
FUNDING.

3726
02:17:28,880 --> 02:17:33,200
THE PROGRAM DOES HAVE A FOCUS ON

3727
02:17:33,200 --> 02:17:34,400
SUPPORTING WOMEN AND MINORITY

3728
02:17:34,400 --> 02:17:36,920
OWNED SMALL BUSINESSES AS WELL.

3729
02:17:36,920 --> 02:17:38,840
TO THE NEXT SLIDE.

3730
02:17:38,840 --> 02:17:40,160
HERE WE KIND OF TALK I THINK I

3731
02:17:40,160 --> 02:17:42,160
MENTIONED A FEW THINGS HERE,

3732
02:17:42,160 --> 02:17:45,920
THAT IF YOU ARE TO BE ELIGIBLE

3733
02:17:45,920 --> 02:17:50,320
YOU HAVE NEVER GOTTEN NIH GRANT,

3734
02:17:50,320 --> 02:17:51,880
COMPANY DOESN'T HAVE CURRENT

3735
02:17:51,880 --> 02:17:54,560
APPLICATION UNDER REVIEW, WE

3736
02:17:54,560 --> 02:17:57,760
AGAIN TRY TO MAKE SURE THAT

3737
02:17:57,760 --> 02:18:00,120
THESE INTERESTS OF FOCUS OF THE

3738
02:18:00,120 --> 02:18:01,880
APPLICATIONS ALIGN WITH THOSE

3739
02:18:01,880 --> 02:18:03,800
INTEREST OF THE PARTICIPATING

3740
02:18:03,800 --> 02:18:04,320
INSTITUTES.

3741
02:18:04,320 --> 02:18:05,920
MENT WE ARE LOOKING AT THE

3742
02:18:05,920 --> 02:18:08,280
PROGRAM OVERALL TO DETERMINE

3743
02:18:08,280 --> 02:18:10,800
WHETHER IT IS SUCCESSFUL AND

3744
02:18:10,800 --> 02:18:12,360
HOPEFULLY NEXT TIME WE MEET I

3745
02:18:12,360 --> 02:18:14,360
WILL BE ABLE TO PROVIDE MORE

3746
02:18:14,360 --> 02:18:18,200
DATA AROUND THAT.

3747
02:18:18,200 --> 02:18:20,160
WE FOLLOW SOMETHING LIKE REALLY

3748
02:18:20,160 --> 02:18:21,680
WOULD BE A GOOD INVESTMENT OF

3749
02:18:21,680 --> 02:18:23,120
TIME AND ENERGY TO TRY TO FIGURE

3750
02:18:23,120 --> 02:18:24,440
OUT HOW TO HELP CERTAIN

3751
02:18:24,440 --> 02:18:26,400
APPLICANTS GET OVER THIS HUMP OF

3752
02:18:26,400 --> 02:18:29,320
GITTING FUNDING FOR UNDER THIS

3753
02:18:29,320 --> 02:18:36,360
SPECIFIC PROGRAM.

3754
02:18:36,360 --> 02:18:37,840
SO INITIATIVES WE ARE DOING

3755
02:18:37,840 --> 02:18:39,320
AROUND OUTREACH AND DRIVING

3756
02:18:39,320 --> 02:18:43,160
AWARENESS TO THE NCATS SBIR STTR

3757
02:18:43,160 --> 02:18:46,240
PROGRAM, NEXT SLIDE SO OUR

3758
02:18:46,240 --> 02:18:49,880
OBJECTIVES ARE GETTING PEOPLE TO

3759
02:18:49,880 --> 02:18:50,400
BE AWARE OF WHAT TYPES OF

3760
02:18:50,400 --> 02:18:52,360
PROJECTS WE ARE FUNDING UNDER

3761
02:18:52,360 --> 02:18:53,680
THE PROGRAM, TO INCREASE THE

3762
02:18:53,680 --> 02:18:55,760
NUMBER OF APPLICATIONS THAT

3763
02:18:55,760 --> 02:18:59,720
WOMEN OWN AND MINORITY OWNED

3764
02:18:59,720 --> 02:19:02,080
SMALL BUSINESSES APPLY TO US

3765
02:19:02,080 --> 02:19:03,320
INCREASING THOSE NUMBERS OF

3766
02:19:03,320 --> 02:19:08,920
QUALITY APPLICATIONS, ALSO SMALL

3767
02:19:08,920 --> 02:19:10,080
BUSINESSES IN STATES THAT

3768
02:19:10,080 --> 02:19:12,400
TYPICALLY DON'T GET A LOT OF NIH

3769
02:19:12,400 --> 02:19:14,520
FUNDING EITHER TRYING TO FOCUS

3770
02:19:14,520 --> 02:19:15,640
EFFORTS AND OUTREACH AROUND THAT

3771
02:19:15,640 --> 02:19:19,000
TOO, IN GENERAL ADVANCING

3772
02:19:19,000 --> 02:19:20,120
INVASION AND DRUG DEVELOPMENT

3773
02:19:20,120 --> 02:19:21,120
DISCOVERY RESEARCH TOOLS AND

3774
02:19:21,120 --> 02:19:22,520
TECHNOLOGIES THAT IMPROVE

3775
02:19:22,520 --> 02:19:24,880
PATIENT CARE AND THOSE RESEARCH

3776
02:19:24,880 --> 02:19:26,960
TOPICS THAT ARE OF GREAT

3777
02:19:26,960 --> 02:19:28,520
IMPORTANCE AND PRIORITY TO

3778
02:19:28,520 --> 02:19:32,920
NCATS.  NEXT SLIDE.

3779
02:19:32,920 --> 02:19:34,240
THIS PAST YEAR EVEN THOUGH WE

3780
02:19:34,240 --> 02:19:37,680
WEREN'T ABLE TO DO IN PERSON

3781
02:19:37,680 --> 02:19:39,800
OUTREACH WE DID A FAIR AMOUNT OF

3782
02:19:39,800 --> 02:19:42,680
WEBINARS WE WERE QUITE BUSY AND

3783
02:19:42,680 --> 02:19:43,800
PARTNERED WITH VARIOUS GROUPS TO

3784
02:19:43,800 --> 02:19:47,200
GET WEBINARS IN PLACE, STATE BIO

3785
02:19:47,200 --> 02:19:48,640
ORGANIZATIONS, AS WELL AS

3786
02:19:48,640 --> 02:19:54,240
ACADEMIC TECH TRANSFER OFFICES,

3787
02:19:54,240 --> 02:19:55,680
INNOVATION HUBS AND ACCELERATORS

3788
02:19:55,680 --> 02:19:56,800
AND GOVERNMENTAL PARTNERS WE

3789
02:19:56,800 --> 02:20:02,640
WORKED WITH TO DO JOINT OUTREACH

3790
02:20:02,640 --> 02:20:05,560
EVENTS.

3791
02:20:05,560 --> 02:20:07,160
I WANT TO POINT OUT WE HAVE BEEN

3792
02:20:07,160 --> 02:20:08,640
BUSY THOUGH NOT ABLE TO DO IN

3793
02:20:08,640 --> 02:20:13,800
PERSON OUTREACH.

3794
02:20:13,800 --> 02:20:18,600
THIS PAST YEAR WE WERE ABLE TO

3795
02:20:18,600 --> 02:20:21,520
GET PARTICIPATION TO WEBINARS

3796
02:20:21,520 --> 02:20:24,320
FROM 45 STATES, AND 45 SATES

3797
02:20:24,320 --> 02:20:29,640
WERE IDEA STATES, WHICH WE WERE

3798
02:20:29,640 --> 02:20:30,920
PURPOSEFULLY TARGETING.

3799
02:20:30,920 --> 02:20:31,680
THIS PAST YEAR WE TALKED TO A

3800
02:20:31,680 --> 02:20:36,280
HUNDRED APPLICANTS AND -- I WILL

3801
02:20:36,280 --> 02:20:37,720
TALK ABOUT HOW WE TRACK WHAT

3802
02:20:37,720 --> 02:20:41,280
HAPPENS AFTER THOSE

3803
02:20:41,280 --> 02:20:42,120
CONVERSATIONS WHAT HAPPENS TO

3804
02:20:42,120 --> 02:20:44,320
THE APPLICANTS BUT THIS YEAR WE

3805
02:20:44,320 --> 02:20:45,400
WANT TO TARGET OTHER STATES WE

3806
02:20:45,400 --> 02:20:47,120
WEREN'T ABLE TO MAKE IN ROADS IN

3807
02:20:47,120 --> 02:20:48,600
AND THERE'S ONLY A FEW OF THEM

3808
02:20:48,600 --> 02:20:50,240
HERE THAT WE HAVE LISTED.

3809
02:20:50,240 --> 02:20:51,920
BUT THAT IS PRIORITY NUMBER ONE

3810
02:20:51,920 --> 02:20:53,840
GOING INTO FY 22.

3811
02:20:53,840 --> 02:20:58,000
NEXT SLIDE.

3812
02:20:58,000 --> 02:20:59,920
WE HAVE A SOCIAL ENGAGEMENT

3813
02:20:59,920 --> 02:21:01,360
CALENDAR WE PUT TOGETHER EVERY

3814
02:21:01,360 --> 02:21:04,520
MONTH WITH OUR COMS TEAM.

3815
02:21:04,520 --> 02:21:07,560
WE HAVE GOTTEN TRAFFIC AS A

3816
02:21:07,560 --> 02:21:09,320
RESULT OF THE EFFORTS WE HAVE

3817
02:21:09,320 --> 02:21:12,320
BEEN DOING EVERY TUESDAY WE HAVE

3818
02:21:12,320 --> 02:21:16,280
A TIP TUESDAY SOCIAL ENGAGEMENT

3819
02:21:16,280 --> 02:21:17,960
THAT GOES OUT ABOUT HOW TO PUT

3820
02:21:17,960 --> 02:21:19,400
IN AN APPLICATION TOGETHER,

3821
02:21:19,400 --> 02:21:21,520
ADVISING APPLICANTS WHAT TO DO

3822
02:21:21,520 --> 02:21:22,680
FOR PARTICULAR FUNDING

3823
02:21:22,680 --> 02:21:24,760
ANNOUNCEMENT.

3824
02:21:24,760 --> 02:21:27,440
WE HIGHLIGHT NCATS STAFF

3825
02:21:27,440 --> 02:21:29,560
INVOLVED WITH THE PROGRAM

3826
02:21:29,560 --> 02:21:30,400
UPCOMING WEBINARS.

3827
02:21:30,400 --> 02:21:33,400
ANOTHER THING THAT IS VERY

3828
02:21:33,400 --> 02:21:36,520
SUCCESSFUL ARE THESE QUOTE CARDS

3829
02:21:36,520 --> 02:21:42,280
HIGHLIGHT SOME OF OUR GRANTEES

3830
02:21:42,280 --> 02:21:44,240
AND SPECIFICALLY SOME HIGHLIGHT

3831
02:21:44,240 --> 02:21:45,600
AROUND COMPANIES, MILESTONE THEY

3832
02:21:45,600 --> 02:21:46,440
REACHED IF WE CAN GO TO THE NEXT

3833
02:21:46,440 --> 02:21:50,280
SLIDE.

3834
02:21:50,280 --> 02:21:54,600
BY WAY OF EXAMPLE, THIS PAST

3835
02:21:54,600 --> 02:21:56,440
YEAR WE HAVE WORKED CLOSELY WITH

3836
02:21:56,440 --> 02:21:59,960
OUR PROGRAM OFFICERS AND ALSO

3837
02:21:59,960 --> 02:22:01,000
HAVE ALERTS SO WE KNOW WHEN

3838
02:22:01,000 --> 02:22:04,920
COMPANIES WE HAVE FUNDED HAVE

3839
02:22:04,920 --> 02:22:06,360
GOTTEN ACANNINGAL FUNDING OR

3840
02:22:06,360 --> 02:22:07,840
CREATED A STRATEGIC PARTNERSHIP,

3841
02:22:07,840 --> 02:22:09,760
WE TALKED TO THAT GRANTEE, TO

3842
02:22:09,760 --> 02:22:12,360
FIND OUT WHAT IS GOING ON.

3843
02:22:12,360 --> 02:22:14,520
AND AMPLIFY THE FACT THAT THEY

3844
02:22:14,520 --> 02:22:16,920
HAVE REACHED A MILESTONE.

3845
02:22:16,920 --> 02:22:20,000
GREAT WAY ENGAGING COMPANY BUT

3846
02:22:20,000 --> 02:22:21,120
ALSO OTHERS ABOUT GOOD WORK WE

3847
02:22:21,120 --> 02:22:25,760
ARE DOING WITH PROGRAM AND

3848
02:22:25,760 --> 02:22:27,120
ENTREPRENEURS THAT WE ARE

3849
02:22:27,120 --> 02:22:29,880
FOCUSING AS PART OF THE SOCIAL

3850
02:22:29,880 --> 02:22:32,320
ENGAGEMENT OPPORTUNITIES HERE.

3851
02:22:32,320 --> 02:22:37,520
NEXT SLIDE.

3852
02:22:37,520 --> 02:22:39,880
/TALK ABOUT FACT WE HAVE HAD --

3853
02:22:39,880 --> 02:22:42,760
WE DID 100 INDIVIDUALCALS WITH

3854
02:22:42,760 --> 02:22:44,480
INDIVIDUALS WHO NEEDED TO TALK

3855
02:22:44,480 --> 02:22:47,720
TO US ABOUT PROJECTS AND WE --

3856
02:22:47,720 --> 02:22:49,640
WHEN WE FIRST STARTED OUT WE HAD

3857
02:22:49,640 --> 02:22:51,920
A HARD TIME TRACKING WHO WE

3858
02:22:51,920 --> 02:22:52,920
SPOKE TO BUT MORE IMPORTANTLY

3859
02:22:52,920 --> 02:22:53,760
WHAT HAPPENED AFTER THAT

3860
02:22:53,760 --> 02:22:54,920
CONVERSATION.

3861
02:22:54,920 --> 02:22:56,920
SO NOW WE ARE UTILIZING SALES

3862
02:22:56,920 --> 02:22:59,720
FORCE TO GIVE US AN IDEA OF WHEN

3863
02:22:59,720 --> 02:23:02,120
THESE CONVERSATIONS HAPPEN, HOW

3864
02:23:02,120 --> 02:23:04,120
LONG DOES IT TAKE THE APPLICANT

3865
02:23:04,120 --> 02:23:05,200
TO I APPLY TO THE PROGRAM AND

3866
02:23:05,200 --> 02:23:08,240
ONCE THEY APPLY, HOW SUCCESSFUL

3867
02:23:08,240 --> 02:23:08,720
WERE THEY.

3868
02:23:08,720 --> 02:23:10,760
ARE THEY APPLYING FOR OTHER

3869
02:23:10,760 --> 02:23:14,200
GRANTS AND NOW THIS -- OUR SALES

3870
02:23:14,200 --> 02:23:15,760
FORCE APPLICATION IS ABLE TO

3871
02:23:15,760 --> 02:23:17,720
TALK TO THE NIH SYSTEM SO WE ARE

3872
02:23:17,720 --> 02:23:21,720
ABLE TO SEE REAL TIME GRANTS AT

3873
02:23:21,720 --> 02:23:26,480
THESE POTENTIAL APPLICANTS HAVE

3874
02:23:26,480 --> 02:23:27,280
AND TRACK WHAT CONVERSATIONS

3875
02:23:27,280 --> 02:23:28,760
HAVE LED TO.

3876
02:23:28,760 --> 02:23:30,920
IT IS A GREAT TOOL TO KEEP TRACK

3877
02:23:30,920 --> 02:23:33,520
OF CERTAIN CAMPAIGNS THAT WE ARE

3878
02:23:33,520 --> 02:23:38,120
DOING WEBINARS, WHAT'S BEEN THE

3879
02:23:38,120 --> 02:23:41,680
INTEREST AROUND PARTICIPATION

3880
02:23:41,680 --> 02:23:43,200
POST WEBINAR WITH FOLKS COMING

3881
02:23:43,200 --> 02:23:44,320
TO NCATS, APPLYING TO THE

3882
02:23:44,320 --> 02:23:51,520
PROGRAM.

3883
02:23:51,520 --> 02:23:54,360
I WILL GIVE DATA, I TALKED

3884
02:23:54,360 --> 02:23:55,400
INITIATIVES AROUND THE PROGRAM

3885
02:23:55,400 --> 02:23:56,600
SO NOW THIS TIME THE TALK TO

3886
02:23:56,600 --> 02:24:07,400
DATA SO LET'S DO THAT.

3887
02:24:07,400 --> 02:24:09,880
QUICKLY TO GIVE YOU SENSE OF

3888
02:24:09,880 --> 02:24:11,400
PROGRAM, IT IS 25 MILLION THAT

3889
02:24:11,400 --> 02:24:13,960
GOES TO FUNDING SMALL BUSINESSES

3890
02:24:13,960 --> 02:24:15,680
SBIR STTR.

3891
02:24:15,680 --> 02:24:18,440
AT ANY GIVEN YEAR E WE HAVE

3892
02:24:18,440 --> 02:24:22,960
ABOUT I WOULD SAY LIKE A 15 TO

3893
02:24:22,960 --> 02:24:27,000
80 -- 15 OR 20% OF OUR BUDGET

3894
02:24:27,000 --> 02:24:29,120
GOES TO FUNDING THOSE SBIR

3895
02:24:29,120 --> 02:24:30,120
CONTRACTS THAT I MENTIONED

3896
02:24:30,120 --> 02:24:32,600
EARLIER AND THE REST REALLY GOES

3897
02:24:32,600 --> 02:24:33,520
TOWARDS SUPPORTING THE GRANT

3898
02:24:33,520 --> 02:24:37,200
PROGRAM.

3899
02:24:37,200 --> 02:24:41,120
TO THE NEXT SLIDE.

3900
02:24:41,120 --> 02:24:43,120
IF YOU WERE TO LOOK AT OUR

3901
02:24:43,120 --> 02:24:44,120
PORTFOLIO THIS PACIFIST WALL

3902
02:24:44,120 --> 02:24:46,760
YEAR I WOULD SAY THAT THEY FALL

3903
02:24:46,760 --> 02:24:50,320
INTO FOUR BUCKETS THE MAJORITY

3904
02:24:50,320 --> 02:24:52,200
ARE AROUND TOOLS AND

3905
02:24:52,200 --> 02:24:54,120
TECHNOLOGIES FOR DRUG DISCOVERY

3906
02:24:54,120 --> 02:24:58,920
AND DEVELOPMENT, IT IS A BROAD

3907
02:24:58,920 --> 02:25:02,920
TOPIC, WE ALSO HAVE DEVICE

3908
02:25:02,920 --> 02:25:04,280
PORTION OF OUR PORTFOLIO A LOT

3909
02:25:04,280 --> 02:25:09,200
OF OUR TISSUE CHIP FALLS UNDER

3910
02:25:09,200 --> 02:25:10,120
THAT SLIVER OF DEVICE.

3911
02:25:10,120 --> 02:25:11,840
GENE THERAPY BECAUSE WE HAVE A

3912
02:25:11,840 --> 02:25:13,320
FOCUS PROGRAM ANNOUNCEMENT

3913
02:25:13,320 --> 02:25:14,880
AROUND GENE THERAPY AND THEN THE

3914
02:25:14,880 --> 02:25:23,840
REST AROUND BIOINFORMATICS.

3915
02:25:23,840 --> 02:25:26,720
SO THIS IS SHOWING OVER TIME THE

3916
02:25:26,720 --> 02:25:28,320
NUMBERS OF APPLICATIONS THAT WE

3917
02:25:28,320 --> 02:25:33,120
HAVE BEEN GETTING IN AND COUPLE

3918
02:25:33,120 --> 02:25:33,920
OF OBSERVATIONS.

3919
02:25:33,920 --> 02:25:35,840
ONE WE DON'T TALK ABOUT THIS

3920
02:25:35,840 --> 02:25:38,240
PROGRAM WE DON'T SEE -- PEOPLE

3921
02:25:38,240 --> 02:25:39,280
DON'T APPLY SO YOU HAVE TO IN

3922
02:25:39,280 --> 02:25:43,240
ORDER TO GET PEOPLE/NEW FRESH

3923
02:25:43,240 --> 02:25:44,480
GRANTEES TO THE MIX YOU NEED TO

3924
02:25:44,480 --> 02:25:46,040
BE TALKING ABOUT THE PROGRAM AND

3925
02:25:46,040 --> 02:25:47,520
DOING OUTREACH ON A PRETTY

3926
02:25:47,520 --> 02:25:50,400
CONSISTENT BASIS.

3927
02:25:50,400 --> 02:25:53,200
THE OTHER THING WE NOTICED WAS A

3928
02:25:53,200 --> 02:25:58,480
DROP IN 2020 OF APPLICATIONS AND

3929
02:25:58,480 --> 02:26:00,560
MANY APPLICANTS THOUGH HOME

3930
02:26:00,560 --> 02:26:02,720
BOUND HAD TIME, THEY HAD OTHER

3931
02:26:02,720 --> 02:26:05,720
RESPONSIBILITIES, I KNOW THAT

3932
02:26:05,720 --> 02:26:07,160
ANECDOTALLY SEVERAL APPLICANTS

3933
02:26:07,160 --> 02:26:08,440
SAID IT WAS HARD TO WRITE A

3934
02:26:08,440 --> 02:26:09,280
GRANT WHEN THEY WERE HAVING TO

3935
02:26:09,280 --> 02:26:11,920
TAKE CARE OF KIDS OR PARENTS

3936
02:26:11,920 --> 02:26:12,520
DURING COVID.

3937
02:26:12,520 --> 02:26:17,480
SO WE DID SEE A DROP IN

3938
02:26:17,480 --> 02:26:20,080
APPLICATIONS HAPPENING AND ALSO

3939
02:26:20,080 --> 02:26:21,080
SOME OF OUR COMPANIES WERE

3940
02:26:21,080 --> 02:26:23,520
IMPACTED BY THE FACT THAT THEY

3941
02:26:23,520 --> 02:26:25,320
COULDN'T HIRE DURING THE

3942
02:26:25,320 --> 02:26:26,800
PANDEMIC SO THAT DELAYED THEM

3943
02:26:26,800 --> 02:26:28,000
PERHAPS MOVING FROM THE PHASE 1

3944
02:26:28,000 --> 02:26:32,480
TO THE PHASE 2.

3945
02:26:32,480 --> 02:26:34,280
IN 2021 BESTARTED TO SEE AN

3946
02:26:34,280 --> 02:26:36,160
INCREASE BACK -- WE STARTED TO

3947
02:26:36,160 --> 02:26:38,080
SEE AN INCREASE BACK AGAIN IN

3948
02:26:38,080 --> 02:26:40,080
NUMBER OF APPLICATIONS THAT CAME

3949
02:26:40,080 --> 02:26:40,560
TO US.

3950
02:26:40,560 --> 02:26:41,080
NEXT SLIDE.

3951
02:26:41,080 --> 02:26:44,480
HERE WE ARE FOCUSING ON AWARDED

3952
02:26:44,480 --> 02:26:46,520
APPLICATIONS.

3953
02:26:46,520 --> 02:26:48,720
TYPICALLY AT ANY GIVEN TIME I

3954
02:26:48,720 --> 02:26:50,520
THINK WE RUN ANYWHERE BETWEEN 25

3955
02:26:50,520 --> 02:26:52,640
TO 35 APPLICATIONS THAT WE --

3956
02:26:52,640 --> 02:26:54,000
NEW APPLICATIONS WE FUND EVERY

3957
02:26:54,000 --> 02:26:55,200
YEAR.

3958
02:26:55,200 --> 02:26:58,760
NEXT SLIDE.

3959
02:26:58,760 --> 02:27:01,080
HOW DO -- WHAT ARE -- DOES OUR

3960
02:27:01,080 --> 02:27:03,160
PRIORITY SCORE, WHAT ARE WE

3961
02:27:03,160 --> 02:27:04,520
FUNDING THE QUESTION WE GET

3962
02:27:04,520 --> 02:27:10,040
OFTEN AND I THINK OVER TIME WE

3963
02:27:10,040 --> 02:27:14,360
HAVE SEEN IMPROVEMENT IN THE

3964
02:27:14,360 --> 02:27:16,640
AVERAGE PRIORITY SCORES NCATS

3965
02:27:16,640 --> 02:27:20,040
FUNDS IN SBIR, AGAIN PRETTY

3966
02:27:20,040 --> 02:27:20,960
PREDICTABLE WHAT OUR BUDGET IS

3967
02:27:20,960 --> 02:27:22,120
GOING TO BE SO WE KNOW WHETHER

3968
02:27:22,120 --> 02:27:23,360
KIND OF OUTREACH THAT WE HAVE TO

3969
02:27:23,360 --> 02:27:27,520
DO IN OUR APPLICANTS -- WE HAVE

3970
02:27:27,520 --> 02:27:30,640
REPEAT GRANTEES WHO COME BACK TO

3971
02:27:30,640 --> 02:27:33,400
US AND FUND VARIOUS PROJECTS.

3972
02:27:33,400 --> 02:27:36,360
SO I DO THINK THAT IT IS

3973
02:27:36,360 --> 02:27:40,400
LEVELING OFF AND THIS IS KIND OF

3974
02:27:40,400 --> 02:27:44,960
WHAT FY 20 -- FY 21 WAS VERY

3975
02:27:44,960 --> 02:27:47,680
COMPETITIVE YEAR.

3976
02:27:47,680 --> 02:27:49,320
BECAUSE WE HAVE SEEN OUR

3977
02:27:49,320 --> 02:27:50,480
APPLICANTS NOT COME IN FOR

3978
02:27:50,480 --> 02:27:52,280
ADDITIONAL FUNDING BECAUSE THEY

3979
02:27:52,280 --> 02:27:53,560
HAVEN'T BEEN ABLE TO FINISH

3980
02:27:53,560 --> 02:27:54,760
THEIR AIMS AND GRANT BECAUSE OF

3981
02:27:54,760 --> 02:27:56,760
COVID.

3982
02:27:56,760 --> 02:27:59,880
I DO EXPECT IT TO BE A DIFFERENT

3983
02:27:59,880 --> 02:28:03,760
NUMBER THIS NEXT IN THISY 2022.

3984
02:28:03,760 --> 02:28:05,320
WE WILL SEE WHAT HAPPENS SO WHAT

3985
02:28:05,320 --> 02:28:06,600
DO WE LOOK LIKE COMPARED TO THE

3986
02:28:06,600 --> 02:28:07,200
REST OF NIH?

3987
02:28:07,200 --> 02:28:11,080
NEXT SLIDE.

3988
02:28:11,080 --> 02:28:11,880
WE ARE CLOSE.

3989
02:28:11,880 --> 02:28:14,680
SOME YEARS WE ARE DOING BETTER

3990
02:28:14,680 --> 02:28:17,240
THAN WHAT NIH AVERAGE PRIORITY

3991
02:28:17,240 --> 02:28:19,680
SCORES ARE FOR SBIR AND SOME

3992
02:28:19,680 --> 02:28:23,320
YEARS WE ARE DOING A LITTLE BIT

3993
02:28:23,320 --> 02:28:24,120
WORSE.

3994
02:28:24,120 --> 02:28:26,480
CONSISTENTLY WE ARE STAYING

3995
02:28:26,480 --> 02:28:28,120
ALONG THE LINES OF WHAT NIH

3996
02:28:28,120 --> 02:28:30,520
FUNDS FOR SBIR.

3997
02:28:30,520 --> 02:28:36,040
TO THE NEXT SLIDE.

3998
02:28:36,040 --> 02:28:37,320
EYE A LITTLE BIT DIFFERENT.

3999
02:28:37,320 --> 02:28:38,360
COUPLE OF REASONS.

4000
02:28:38,360 --> 02:28:39,600
ONE IS THAT OUR BUDGET IS NOT

4001
02:28:39,600 --> 02:28:41,720
THAT HIGH FOR STTR SO OUR

4002
02:28:41,720 --> 02:28:44,520
APPLICANTS COME IN AND FIGURE

4003
02:28:44,520 --> 02:28:46,200
AND SAY I WILL TAKE A CHANCE AND

4004
02:28:46,200 --> 02:28:48,800
GOING TO APPLY FOR SBIR BECAUSE

4005
02:28:48,800 --> 02:28:49,800
I FEEL LIKE I HAVE A BETTER

4006
02:28:49,800 --> 02:28:52,840
CHANCE THERE.

4007
02:28:52,840 --> 02:28:55,160
SOME YEARS WHAT WE SEE IS DROP

4008
02:28:55,160 --> 02:28:56,600
OFF IN NUMBER OF APPLICATIONS

4009
02:28:56,600 --> 02:29:00,160
THAT COME IN UNDER SPECIFIC --

4010
02:29:00,160 --> 02:29:02,520
UNDER STTR.

4011
02:29:02,520 --> 02:29:06,560
OTHER YEARS WE SEE A FEW PHASE

4012
02:29:06,560 --> 02:29:08,320
2s TAKE UM THE BUDGET WHICH

4013
02:29:08,320 --> 02:29:10,240
LIMITS WHAT WE CAN FUND.  SO

4014
02:29:10,240 --> 02:29:12,880
FREE YEAR-TO-YEAR THERE IS

4015
02:29:12,880 --> 02:29:13,840
FLUCTUATION WITH WHAT WE FUND

4016
02:29:13,840 --> 02:29:18,160
UNDER THE PROGRAM.

4017
02:29:18,160 --> 02:29:20,200
SHOWING HOW WE ARE DOING WITH

4018
02:29:20,200 --> 02:29:24,440
REST OF NIH, I THINK IT HAS BEEN

4019
02:29:24,440 --> 02:29:25,920
A LITTLE ALL OVER PLACE.

4020
02:29:25,920 --> 02:29:27,280
DEPENDS ON WHETHER THERE'S A

4021
02:29:27,280 --> 02:29:29,080
STREAM OF APPLICATIONS COMING

4022
02:29:29,080 --> 02:29:33,000
IN, WHETHER THERE'S PHASE 2s

4023
02:29:33,000 --> 02:29:36,320
TO FUND.

4024
02:29:36,320 --> 02:29:37,760
APPLICANTS COMING IN SAYING I'M

4025
02:29:37,760 --> 02:29:40,000
GOING TO PUT TOGETHER ABIR

4026
02:29:40,000 --> 02:29:44,680
VERSUS STTR.

4027
02:29:44,680 --> 02:29:46,160
ANOTHER THING WE HAVE BEEN

4028
02:29:46,160 --> 02:29:51,360
TRACKING TO IS WOMEN OWNED AND

4029
02:29:51,360 --> 02:29:52,840
MINORITY OWNED SMALL BUSINESSES

4030
02:29:52,840 --> 02:29:55,240
COMING AND APPLYING.

4031
02:29:55,240 --> 02:29:57,480
DROVES A DROP OFF IN 2019.

4032
02:29:57,480 --> 02:30:01,520
WE ACCOUNT THAT TO CHANGE IN HOW

4033
02:30:01,520 --> 02:30:02,240
DATA IS COLLECTED.

4034
02:30:02,240 --> 02:30:04,400
THE DATA USED TO BE COLLECTED AT

4035
02:30:04,400 --> 02:30:05,520
THE NIH LEVEL WITHIN YOU PUT

4036
02:30:05,520 --> 02:30:10,280
YOUR APPLICATION IN, YOU WOULD

4037
02:30:10,280 --> 02:30:11,920
TAKE WHETHER YOU WERE MINORITY

4038
02:30:11,920 --> 02:30:14,080
OWNED OR WOMAN OWNED SMALL

4039
02:30:14,080 --> 02:30:16,200
BUSINESS VERY DEPENDENT ON SBA

4040
02:30:16,200 --> 02:30:17,120
GUIDELINES.

4041
02:30:17,120 --> 02:30:19,920
NOW THAT DATA IS CAPTURED ON THE

4042
02:30:19,920 --> 02:30:22,720
SBA SITE SIDE WHEN YOU REGISTER,

4043
02:30:22,720 --> 02:30:24,360
YOU DO YOUR SBA REGISTRATION.

4044
02:30:24,360 --> 02:30:27,320
AND WE HAVE SEEN A SHIFT IN THE

4045
02:30:27,320 --> 02:30:28,520
NUMBERS.

4046
02:30:28,520 --> 02:30:30,920
IF YOU LOOK LOOK AT HER PARTS OF

4047
02:30:30,920 --> 02:30:32,600
NIH YOU SEE SIMILAR SHIFTS AS

4048
02:30:32,600 --> 02:30:34,080
WELL TOO IN TERMS OF DATE

4049
02:30:34,080 --> 02:30:39,240
CAPTURE.

4050
02:30:39,240 --> 02:30:39,880
TO THE NEXT SLIDE.

4051
02:30:39,880 --> 02:30:42,320
I WILL END WITH SUCCESSORRIES.

4052
02:30:42,320 --> 02:30:46,040
AS PART OF THE TEN YEAR

4053
02:30:46,040 --> 02:30:49,560
ANNIVERSARY WE TALKED ABOUT WHAT

4054
02:30:49,560 --> 02:30:51,640
WE DID ON I BELIEVE DECEMBER 7

4055
02:30:51,640 --> 02:30:54,560
WE HAD THIS BIG LOT OF

4056
02:30:54,560 --> 02:30:57,240
PARTICIPATION AROUND THE TEN

4057
02:30:57,240 --> 02:30:58,240
YEAR ANNIVERSARY BUT ALSO

4058
02:30:58,240 --> 02:31:00,720
DECIDED TO DO SOMETHING WITH

4059
02:31:00,720 --> 02:31:02,920
SBIR TOO AND HIGHLIGHT THREE

4060
02:31:02,920 --> 02:31:05,840
SUCCESS STORIES WITH COUPLE OF

4061
02:31:05,840 --> 02:31:07,960
OF OUR GRANTEES.

4062
02:31:07,960 --> 02:31:09,880
LET ME GO THROUGH SOME OF THE

4063
02:31:09,880 --> 02:31:10,280
STORIES.

4064
02:31:10,280 --> 02:31:13,760
I WANT O GET A GOOD

4065
02:31:13,760 --> 02:31:15,920
REPRESENTATION OF DIFFERENT

4066
02:31:15,920 --> 02:31:18,800
PARTS OF THE ENTREPRENEURIAL

4067
02:31:18,800 --> 02:31:20,560
CYCLE TO GIVE ILLUSTRATE HOW

4068
02:31:20,560 --> 02:31:22,480
THESE COMPANIES USE THE GRANT

4069
02:31:22,480 --> 02:31:24,160
MORE IMPORTANTLY HOW THEY HAVE

4070
02:31:24,160 --> 02:31:27,480
GOT TO KEY INFLECTION POINTS

4071
02:31:27,480 --> 02:31:29,120
ALONG THE WAY -- MOVING THEIR

4072
02:31:29,120 --> 02:31:30,000
TECHNOLOGY FOR

4073
02:31:30,000 --> 02:31:31,560
COMMERCIALIZATION.

4074
02:31:31,560 --> 02:31:34,240
LET'S GO TO NEXT SLIDE.

4075
02:31:34,240 --> 02:31:38,440
WE HAD DR. LIN PARKS WU WHO

4076
02:31:38,440 --> 02:31:42,320
DEVELOPED THIS PORTABLE SYSTEM

4077
02:31:42,320 --> 02:31:44,520
CALLED THE BLAZE SYSTEM WHICH

4078
02:31:44,520 --> 02:31:48,280
COMBINES MASS SPEC WITH PROTEIN

4079
02:31:48,280 --> 02:31:52,440
IMAGING AND LEONA WAS ABLE TO DO

4080
02:31:52,440 --> 02:31:57,080
THIS WITH DEVELOPMENT WITH SBIR

4081
02:31:57,080 --> 02:31:59,440
BUT SHE SOLD HER COMPANY TO

4082
02:31:59,440 --> 02:32:00,320
(INAUDIBLE) AS A RESULT OF THAT

4083
02:32:00,320 --> 02:32:01,480
SO THE COMPANY WAS INTEREST

4084
02:32:01,480 --> 02:32:04,000
MISDEMEANOR THE PRODUCT AND HER

4085
02:32:04,000 --> 02:32:06,760
EXIT STRATEGY WAS TO SELL THE

4086
02:32:06,760 --> 02:32:08,800
ASSET WHICH IS WHAT SHE DID SHE

4087
02:32:08,800 --> 02:32:11,120
WAS SUCCESSFUL IN DOING THAT BUT

4088
02:32:11,120 --> 02:32:12,360
SBIR HELPED WITH THE EARLY

4089
02:32:12,360 --> 02:32:19,400
DEVELOPMENT OF THE TECHNOLOGY.

4090
02:32:19,400 --> 02:32:23,120
THE NEXT PERSON WAS CHRIS

4091
02:32:23,120 --> 02:32:25,880
GIBSON, CHRIS SURE YOU HAVE

4092
02:32:25,880 --> 02:32:31,280
HEARD ABOUT RE,CURSION.

4093
02:32:31,280 --> 02:32:32,200
ONE OF THE FIRST COMPANIES WE

4094
02:32:32,200 --> 02:32:33,320
FUNDED WHEN WE STARTED THE

4095
02:32:33,320 --> 02:32:33,720
CENTER.

4096
02:32:33,720 --> 02:32:35,960
IT EAT A GREAT STORY BECAUSE

4097
02:32:35,960 --> 02:32:40,560
THAT INITIAL GRANT THAT CHRIS

4098
02:32:40,560 --> 02:32:46,760
WENT FOR OVER TIME COMPANY WAS

4099
02:32:46,760 --> 02:32:48,120
ABLE TO LEVERAGE INVESTMENT,

4100
02:32:48,120 --> 02:32:50,920
CHRIS'S COMPANY WAS SUPPORTED BY

4101
02:32:50,920 --> 02:32:55,160
NIH GOING TO VARIOUS PITCH

4102
02:32:55,160 --> 02:32:59,680
PETITION THAT BIO HAD AND OTHER

4103
02:32:59,680 --> 02:33:00,720
CONFERENCES HE COULD SHOWCASE

4104
02:33:00,720 --> 02:33:03,760
WHAT HE WAS DOING AND TECHNOLOGY

4105
02:33:03,760 --> 02:33:07,920
BUT ONE OF THE KEY THINGS WITH

4106
02:33:07,920 --> 02:33:09,840
RECURSION WAS THEY MEET THE

4107
02:33:09,840 --> 02:33:12,040
PINNACLE MILESTONE LISTED AS

4108
02:33:12,040 --> 02:33:13,040
NASDAQ COMPANY THIS PAST YEAR

4109
02:33:13,040 --> 02:33:16,320
WHICH IS A WONDERFUL STORY AND

4110
02:33:16,320 --> 02:33:18,880
YES THE GRANT HELPED BUT CHRIS'S

4111
02:33:18,880 --> 02:33:21,520
VISION AND WHAT HE'S DONE IS

4112
02:33:21,520 --> 02:33:23,720
REALLY PAVED THE WAY TO SUCCESS

4113
02:33:23,720 --> 02:33:27,440
OF THE COMPANY.

4114
02:33:27,440 --> 02:33:29,440
THEN THE OTHER GRANTEE WE

4115
02:33:29,440 --> 02:33:36,520
FOCUSED ON WAS DR. CHANG KIM

4116
02:33:36,520 --> 02:33:38,920
BASED IN MILWAUKEE, WISCONSIN.

4117
02:33:38,920 --> 02:33:41,640
HE HAD THIS POINT OF CARE

4118
02:33:41,640 --> 02:33:45,600
TECHNOLOGY THAT WE WERE FUNDING

4119
02:33:45,600 --> 02:33:46,520
FOR DIARRHEAL DISEASE AND WHEN

4120
02:33:46,520 --> 02:33:48,880
COVID CAME IN HE SAID I THINK I

4121
02:33:48,880 --> 02:33:50,320
CAN PIVOT AND START ADDRESSING

4122
02:33:50,320 --> 02:33:52,480
COVID USING THE SAME PLATFORM.

4123
02:33:52,480 --> 02:33:54,520
AND THAT IS WHAT HE DID, HE GAVE

4124
02:33:54,520 --> 02:33:59,320
A SUPPLEMENT TO DO THAT.

4125
02:33:59,320 --> 02:34:02,760
AND CHANG HE IS WORKING

4126
02:34:02,760 --> 02:34:05,280
DILIGENTLY TO GET AUTHORIZATION

4127
02:34:05,280 --> 02:34:06,680
FOR THE TECHNOLOGY TO BE USED,

4128
02:34:06,680 --> 02:34:10,400
HE HAS A PORTAL VAN HE GOES

4129
02:34:10,400 --> 02:34:12,960
AROUND MILWAUKEE USING HIS POINT

4130
02:34:12,960 --> 02:34:16,400
OF CARE TECHNOLOGY TO GET COVID

4131
02:34:16,400 --> 02:34:18,120
TESTS AND HE'S BEEN A GREAT

4132
02:34:18,120 --> 02:34:20,800
SUCCESS STORY FOR US AND SHOWING

4133
02:34:20,800 --> 02:34:23,200
HOW YOU CAN PIVOT PLATFORM

4134
02:34:23,200 --> 02:34:24,160
TECHNOLOGIES AND IN THIS CASE WE

4135
02:34:24,160 --> 02:34:25,960
OFFER THE SUPPORT TO GET HIM TO

4136
02:34:25,960 --> 02:34:27,320
THAT NEXT CRITICAL STAGE.

4137
02:34:27,320 --> 02:34:32,080
GO TO NEXT SLIDE.

4138
02:34:32,080 --> 02:34:36,360
FUTURE DIRECTIONS FOR SBER STTR,

4139
02:34:36,360 --> 02:34:37,440
FOCUS ON INCREASING

4140
02:34:37,440 --> 02:34:38,480
PARTICIPATION OF WOMEN AND

4141
02:34:38,480 --> 02:34:39,720
MINORITY OWNED SMALL BUSINESS,

4142
02:34:39,720 --> 02:34:41,720
WE WANT TO CONTINUE TO IDENTIFY

4143
02:34:41,720 --> 02:34:45,240
SUCCESS STORIES IN WAYS OF

4144
02:34:45,240 --> 02:34:49,600
AMPLIFYING OUR COMPANIES

4145
02:34:49,600 --> 02:34:51,360
REACHING PIVOTAL MILESTONES THAT

4146
02:34:51,360 --> 02:34:52,200
SHOW EFFECTIVENESS OF THE

4147
02:34:52,200 --> 02:34:54,040
PROGRAM, PROVIDING EDUCATIONAL

4148
02:34:54,040 --> 02:34:55,080
PROGRAMMING TO GRANTEES HOW TO

4149
02:34:55,080 --> 02:34:56,520
APPLY TO THE PROGRAM, WHAT WE

4150
02:34:56,520 --> 02:34:58,640
ARE LOOKING FOR SPECIFICALLY

4151
02:34:58,640 --> 02:35:02,080
HERE AT NCATS AND MORE

4152
02:35:02,080 --> 02:35:02,920
IMPORTANTLY, HOW TO LEVERAGE

4153
02:35:02,920 --> 02:35:04,520
WHAT WE ARE DOING HERE AT NCATS

4154
02:35:04,520 --> 02:35:05,600
IN TERMS OF SCIENTIFIC

4155
02:35:05,600 --> 02:35:08,080
PRIORITIES AND SEEING SBIR STTR

4156
02:35:08,080 --> 02:35:10,440
AS A WAY OF ALSO GETTING THERE.

4157
02:35:10,440 --> 02:35:13,640
SO IN TERMS OF ASPR COUNCIL

4158
02:35:13,640 --> 02:35:16,080
MEMBERS I WE ARE ALWAYS LOOKING

4159
02:35:16,080 --> 02:35:18,160
FOR OPPORTUNITIES TO DO OUTREACH

4160
02:35:18,160 --> 02:35:19,160
FOR THE PROGRAM, IF YOU HAVE

4161
02:35:19,160 --> 02:35:21,400
SUGGESTION WE WELCOME THOSE.

4162
02:35:21,400 --> 02:35:23,840
AND IDEAS HOW TO LEVERAGE SBIR

4163
02:35:23,840 --> 02:35:27,480
WITH OTHER NCATS INITIATIVES AND

4164
02:35:27,480 --> 02:35:30,120
PROGRAMS, WE AGAIN HAPPY TO

4165
02:35:30,120 --> 02:35:32,400
LISTEN AND I'M GOING TO OPEN IT

4166
02:35:32,400 --> 02:35:49,000
UP FOR QUESTIONS.

4167
02:35:49,000 --> 02:35:51,840
>> I WAS GOING TO FILE IN

4168
02:35:51,840 --> 02:35:52,680
OUTREACH RECOMMENDATIONS --

4169
02:35:52,680 --> 02:35:54,280
GOING TO TIME IN OUTREACH

4170
02:35:54,280 --> 02:35:54,880
RECOMMENDATIONS.

4171
02:35:54,880 --> 02:35:55,440
I DON'T HAVE ANY QUESTIONS.

4172
02:35:55,440 --> 02:35:57,920
JUST A COUPLE OF LEADS FOR HER.

4173
02:35:57,920 --> 02:35:58,320
>> FANTASTIC.

4174
02:35:58,320 --> 02:35:59,320
THANK YOU SO MUCH KELLY,

4175
02:35:59,320 --> 02:36:02,160
APPRECIATE THAT.

4176
02:36:02,160 --> 02:36:06,120
>> HI, LILY.

4177
02:36:06,120 --> 02:36:07,560
ONE OF THE THINGS YOU MIGHT

4178
02:36:07,560 --> 02:36:11,160
THINK ABOUT IN EXTENDING THIS IS

4179
02:36:11,160 --> 02:36:13,240
REALLY IN THAT ACT AND USING

4180
02:36:13,240 --> 02:36:15,360
MENTORS IS TO ALSO PARTNER

4181
02:36:15,360 --> 02:36:18,480
TOGETHER WITH THE CTSA PROGRAMS

4182
02:36:18,480 --> 02:36:20,160
AND OTHERS WHICH COULD REALLY

4183
02:36:20,160 --> 02:36:24,160
USE LOCAL MENTORS SUCCESSFULLY

4184
02:36:24,160 --> 02:36:26,240
TRAVERSES BOTH FROM ACADEMIC AND

4185
02:36:26,240 --> 02:36:28,600
BUSINESS SIDE THAT COULD WORK

4186
02:36:28,600 --> 02:36:30,160
TOGETHER WITH EXTENDING REACH,

4187
02:36:30,160 --> 02:36:32,920
ALSO MAKE IT RELEVANT WITHIN THE

4188
02:36:32,920 --> 02:36:37,680
OWN COMMERCIALIZATION SYSTEMS

4189
02:36:37,680 --> 02:36:40,040
WITHIN OUR ECONOMIC DEVELOPMENT

4190
02:36:40,040 --> 02:36:41,480
THINGS WITHIN THE STATES AND

4191
02:36:41,480 --> 02:36:43,720
MIGHT HELP THAT SUSTAINABILITY

4192
02:36:43,720 --> 02:36:46,560
AS YOU GO PHASE 1 TO PHASE 2 AND

4193
02:36:46,560 --> 02:36:50,320
THIS LESSONS LEARNED THAT I

4194
02:36:50,320 --> 02:36:51,360
THINK MAKE TEAMS MORE

4195
02:36:51,360 --> 02:36:54,000
SUCCESSFUL.

4196
02:36:54,000 --> 02:36:55,440
>> THANKS, BECKY.

4197
02:36:55,440 --> 02:36:58,720
WE HAVE HAD VERY SUCCESSFUL

4198
02:36:58,720 --> 02:37:01,160
ENGAGEMENT WITH VARIOUS CTSAs

4199
02:37:01,160 --> 02:37:03,360
THAT HAVE PARTNERED WITH US TO

4200
02:37:03,360 --> 02:37:05,080
TALK ABOUT THE PROGRAM.

4201
02:37:05,080 --> 02:37:09,240
IN FACT LAST WEEK WE HAD A

4202
02:37:09,240 --> 02:37:12,120
WEBINAR WITH A COMPANY THAT WAS

4203
02:37:12,120 --> 02:37:17,080
STARTED FROM A K 1 SCHOLAR AT UT

4204
02:37:17,080 --> 02:37:19,040
HOUSTON AND HE LICENSED

4205
02:37:19,040 --> 02:37:21,000
TECHNOLOGY INTO THE COMPANY.

4206
02:37:21,000 --> 02:37:26,400
ALSO PARTNERED WITH AN EXPERT

4207
02:37:26,400 --> 02:37:28,000
WITHIN LOCAL CTING ISA.

4208
02:37:28,000 --> 02:37:29,680
WE TALK ABOUT HOW TO ENGAGE WITH

4209
02:37:29,680 --> 02:37:31,440
THE CTSA PROGRAM IF YOU ARE

4210
02:37:31,440 --> 02:37:33,240
SMALL BUSINESS HOW YOU GO ABOUT

4211
02:37:33,240 --> 02:37:34,040
DOING THAT.

4212
02:37:34,040 --> 02:37:36,920
THE WEBINAR WAS VERY SUCCESSFUL

4213
02:37:36,920 --> 02:37:41,520
IN TERMS OF MAKING TALKING THE

4214
02:37:41,520 --> 02:37:43,200
STORY HOW TO BRIDGE THE TWO

4215
02:37:43,200 --> 02:37:44,240
PROGRAMS, I WOULD LOVE TO SEE

4216
02:37:44,240 --> 02:37:45,560
MORE OF THAT OVER TIME AS WELL

4217
02:37:45,560 --> 02:37:48,920
TOO.

4218
02:37:48,920 --> 02:37:50,960
MAYBE WE CAN TALK SEPARATELY AND

4219
02:37:50,960 --> 02:37:52,000
GIVE ME MORE IDEAS ON WHERE TO

4220
02:37:52,000 --> 02:37:55,800
GO.

4221
02:37:55,800 --> 02:38:02,680
>> LOVE TO, WE CAN TALK OFFLINE.

4222
02:38:02,680 --> 02:38:09,120
>> ANY OTHER QUESTIONS FOR LILY?

4223
02:38:09,120 --> 02:38:13,280
>> LILY HOW PRESCRIPTIVE CAN YOU

4224
02:38:13,280 --> 02:38:14,640
MAKE THE RFAs IF YOU WILL FOR

4225
02:38:14,640 --> 02:38:15,120
THESE?

4226
02:38:15,120 --> 02:38:17,080
IS IT JUST SORT OF OPEN

4227
02:38:17,080 --> 02:38:18,400
EVERYTHING OR CAN YOU DO

4228
02:38:18,400 --> 02:38:19,360
TARGETED ANNOUNCEMENTS?

4229
02:38:19,360 --> 02:38:22,080
>> ABSOLUTELY WE CAN DO TARGETED

4230
02:38:22,080 --> 02:38:22,520
ANNOUNCEMENTS.

4231
02:38:22,520 --> 02:38:26,320
YES.

4232
02:38:26,320 --> 02:38:28,840
OUR OMNIBUS TOPICS ARE ON THE

4233
02:38:28,840 --> 02:38:30,200
BROADSIDE BECAUSE WE WANT TO

4234
02:38:30,200 --> 02:38:31,800
CAPTURE AS MUCH AS WE POSSIBLY

4235
02:38:31,800 --> 02:38:36,400
CAN WITH THAT.

4236
02:38:36,400 --> 02:38:38,720
BUT WE DO TARGET SOLICITATION,

4237
02:38:38,720 --> 02:38:40,720
ORDR IS VERY SUCCESSFUL IN

4238
02:38:40,720 --> 02:38:42,080
LEVERAGING WHAT THEY -- THEY ARE

4239
02:38:42,080 --> 02:38:45,080
DOING USING THE TARGETED

4240
02:38:45,080 --> 02:38:45,480
SOLICITATIONS.

4241
02:38:45,480 --> 02:38:50,720
THEY HAD A BASKET TRIAL RFA

4242
02:38:50,720 --> 02:38:52,800
USING A U MECHANISM ABOUT WE

4243
02:38:52,800 --> 02:38:57,040
USED A U 44 MECHANISM ON THE

4244
02:38:57,040 --> 02:38:58,360
SBIR AS COMPLIMENTARY WAY OF

4245
02:38:58,360 --> 02:39:00,720
GETTING SMALL BUSINESS ENGAGED.

4246
02:39:00,720 --> 02:39:02,520
SO IT IS VERY MUCH SOMETHING

4247
02:39:02,520 --> 02:39:04,760
THAT WE WANT TO SEE MORE OF

4248
02:39:04,760 --> 02:39:06,760
GOING FORWARD AND FIGURING HOW

4249
02:39:06,760 --> 02:39:08,120
TO LEVERAGE CURRENT PROGRAMS AND

4250
02:39:08,120 --> 02:39:11,400
INITIATIVES USING SBIR STTR.

4251
02:39:11,400 --> 02:39:14,600
>> COUPLE OF FOLLOW UPS.

4252
02:39:14,600 --> 02:39:17,600
DOES THE END RESULT NEED TO BE A

4253
02:39:17,600 --> 02:39:20,800
PRODUCT OR IT -- CAN IT BE A

4254
02:39:20,800 --> 02:39:29,200
SUSTAINABLE SET OF SERVICES?

4255
02:39:29,200 --> 02:39:30,280
>> TYPICALLY A PRODUCT.

4256
02:39:30,280 --> 02:39:32,040
IN TERMS OF SUSTAINABLE SERVICE,

4257
02:39:32,040 --> 02:39:33,720
IF THERE IS SOMETHING UNIQUE

4258
02:39:33,720 --> 02:39:35,360
ABOUT INNOVATIVE ABOUT THAT

4259
02:39:35,360 --> 02:39:37,520
SERVICE, THAT REQUIRES PERHAPS A

4260
02:39:37,520 --> 02:39:40,480
PLATFORM OF SOME SORT TO DO, WE

4261
02:39:40,480 --> 02:39:43,360
HAVE MANY COMPANIES THAT OFFER

4262
02:39:43,360 --> 02:39:44,880
DRUG DEVELOPMENT SUPPORT AND DO

4263
02:39:44,880 --> 02:39:46,720
IT AS PART OF SERVICE BUT IT IS

4264
02:39:46,720 --> 02:39:48,440
THE TECHNOLOGY THEY USE BEHIND

4265
02:39:48,440 --> 02:39:49,520
THE SCENES THAT IS THE

4266
02:39:49,520 --> 02:39:51,120
INNOVATION THAT WAS FUNDED BY

4267
02:39:51,120 --> 02:39:55,960
SBIR, THAT WOULD BE POSSIBLE.

4268
02:39:55,960 --> 02:39:57,840
>> WHERE MY HEAD IS ON YOUR

4269
02:39:57,840 --> 02:39:59,480
SECOND QUESTION THINKING BACK TO

4270
02:39:59,480 --> 02:40:01,680
JONI'S AUDACIOUS GOALS, LOOKING

4271
02:40:01,680 --> 02:40:04,680
AT WHERE THE GAPS ARE THAT MAY

4272
02:40:04,680 --> 02:40:08,640
WELL NOT BE EASY TO FILL USING

4273
02:40:08,640 --> 02:40:10,400
TRADITIONAL METHODS, SEEMS LIKE

4274
02:40:10,400 --> 02:40:12,760
TARGETED ANNOUNCEMENTS MIGHT

4275
02:40:12,760 --> 02:40:18,680
OFFER A GOOD OPPORTUNITY.

4276
02:40:18,680 --> 02:40:21,480
>> WE ARE UP TO EXPLORING HOW TO

4277
02:40:21,480 --> 02:40:22,240
MAKE THAT HAPPEN.

4278
02:40:22,240 --> 02:40:24,240
IN SOME INSTANCES HAVING THE

4279
02:40:24,240 --> 02:40:26,240
TARGETED ANNOUNCEMENTS IS GOING

4280
02:40:26,240 --> 02:40:27,480
TO GET YOU MORE WHERE YOU

4281
02:40:27,480 --> 02:40:28,960
IMMEDIATE TO GO, MAYBE THAT IS

4282
02:40:28,960 --> 02:40:30,720
EXACTLY IN TERMS OF BRIDGING

4283
02:40:30,720 --> 02:40:34,920
THOSE WITH JONI'S GOALS SHE

4284
02:40:34,920 --> 02:40:35,880
MENTIONED, SPECIFICITY AROUND

4285
02:40:35,880 --> 02:40:37,200
TARGETED SOLICITATION IS REALLY

4286
02:40:37,200 --> 02:40:40,920
THE WAY TO GO OPPOSED TO BEING

4287
02:40:40,920 --> 02:40:47,360
BROAD.

4288
02:40:47,360 --> 02:40:49,560
>> LOVE THAT IDEA.

4289
02:40:49,560 --> 02:40:59,000
ANY OTHER QUESTIONS FOR LILY?

4290
02:40:59,000 --> 02:40:59,760
OKAY.

4291
02:40:59,760 --> 02:41:01,520
HEARING NONE WE HAVE MADE UP

4292
02:41:01,520 --> 02:41:03,240
SOME TIME.

4293
02:41:03,240 --> 02:41:06,240
ANNA, QUICK PROCESS QUESTION

4294
02:41:06,240 --> 02:41:08,280
HERE, SHOULD WE TAKE A BREAK?

4295
02:41:08,280 --> 02:41:11,240
OR PROCEED WITH THE LAST BIT OF

4296
02:41:11,240 --> 02:41:14,880
THE COUNCIL CONCEPT CLEARANCES?

4297
02:41:14,880 --> 02:41:17,720
>> JONI, I THINK FOLKS WOULD

4298
02:41:17,720 --> 02:41:18,520
APPRECIATE A SHORT BREAK.

4299
02:41:18,520 --> 02:41:20,920
WE DO HAVE TIME, WE ARE 20

4300
02:41:20,920 --> 02:41:22,120
MINUTES AHEAD OF SCHEDULE.

4301
02:41:22,120 --> 02:41:24,120
SO TEN MINUTE BREAK WOULDN'T BE

4302
02:41:24,120 --> 02:41:25,280
PROBLEMATIC AT ALL.

4303
02:41:25,280 --> 02:41:28,240
>> SOUNDS GREAT.

4304
02:41:28,240 --> 02:41:29,760
EVERYBODY IN TEN MINUTE BREAK.

4305
02:41:29,760 --> 02:41:30,360
ALL RIGHT.

4306
02:41:30,360 --> 02:41:31,200
LET'S DO IT.

4307
02:41:31,200 --> 02:41:35,520
SEE YOU BACK IN ABOUT TEN A

4308
02:41:35,520 --> 02:41:36,800
LITTLE AFTER TEN OF 4.

4309
02:41:36,800 --> 02:41:38,960
SEE YOU SOON.

4310
02:41:38,960 --> 02:41:41,000
SO NEXT UP IS THE CLEARANCE OF

4311
02:41:41,000 --> 02:41:42,480
CONCEPTS AND WE HAVE A COUPLE

4312
02:41:42,480 --> 02:41:45,680
FOR TODAY AND WE HAVE A COUPLE

4313
02:41:45,680 --> 02:41:47,080
FOR TOMORROW.

4314
02:41:47,080 --> 02:41:49,000
THE FIRST ONE WITHINOR WILL BE

4315
02:41:49,000 --> 02:41:50,160
WITH OFFICE OF POLICY

4316
02:41:50,160 --> 02:41:52,840
COMMUNICATIONS AN EDUCATION

4317
02:41:52,840 --> 02:41:55,080
CONCEPT AND PENNY BURGOON WILL

4318
02:41:55,080 --> 02:41:59,480
KICK OFF AND THEN WE WILL HEAR

4319
02:41:59,480 --> 02:42:02,440
FROM JESSICA TAGLE BADGER.

4320
02:42:02,440 --> 02:42:03,440
>> THANK YOU, GOOD AFTERNOON,

4321
02:42:03,440 --> 02:42:04,040
EVERYBODY.

4322
02:42:04,040 --> 02:42:06,160
HERE TO OVERVIEW OFFICE OF

4323
02:42:06,160 --> 02:42:07,520
POLICY COMMUNICATIONS AND

4324
02:42:07,520 --> 02:42:10,000
EDUCATION.

4325
02:42:10,000 --> 02:42:13,000
I WILL ALSO WEAVE INTO A BRIEF

4326
02:42:13,000 --> 02:42:14,000
INTRODUCTION ABOUT THE CONCEPT

4327
02:42:14,000 --> 02:42:15,160
FOR THE EDUCATION BRANCH.

4328
02:42:15,160 --> 02:42:18,640
NEXT SLIDE PLEASE.

4329
02:42:18,640 --> 02:42:20,520
THE OFFICE OF POLICY

4330
02:42:20,520 --> 02:42:21,880
COMMUNICATIONS AND EDUCATION

4331
02:42:21,880 --> 02:42:26,720
OTHERWISE KNOWN AS OPIC PROVIDES

4332
02:42:26,720 --> 02:42:28,600
GUIDANCE AND SUPPORT FOR NCATS

4333
02:42:28,600 --> 02:42:30,280
ON NUMBER OF ACTIVITIES IN THE

4334
02:42:30,280 --> 02:42:32,160
PURVIEW OF SCIENCE POLICY.

4335
02:42:32,160 --> 02:42:34,880
COMMUNICATIONS AND OUTREACH.

4336
02:42:34,880 --> 02:42:37,640
THE NEWEST BRANCH IS OUR

4337
02:42:37,640 --> 02:42:39,080
EDUCATION AN TRAINING BRANCH.

4338
02:42:39,080 --> 02:42:44,240
THIS IS A GROUP THAT WAS -- WE

4339
02:42:44,240 --> 02:42:46,720
HAD THE ORGANIZATIONAL APPROVAL

4340
02:42:46,720 --> 02:42:48,640
PROBABLY AROUND 2017 BUT WE WERE

4341
02:42:48,640 --> 02:42:51,480
NOT ABLE TO STAFF THE -- THIS

4342
02:42:51,480 --> 02:42:54,480
BRANCH UNTIL 2019.

4343
02:42:54,480 --> 02:42:57,080
NEXT SLIDE PLEASE.

4344
02:42:57,080 --> 02:43:00,000
NOW, THE GOALS OF THE EDUCATION

4345
02:43:00,000 --> 02:43:02,200
BRANCH ARE TO DISSEMINATE AND

4346
02:43:02,200 --> 02:43:03,760
DEVELOP EVIDENCE BASED TOOLS AND

4347
02:43:03,760 --> 02:43:05,000
BEST PRACTICES.

4348
02:43:05,000 --> 02:43:07,080
TO IMPROVE THE UNDERSTANDING OF

4349
02:43:07,080 --> 02:43:08,960
TRANSLATIONAL SCIENCE.

4350
02:43:08,960 --> 02:43:11,200
AND IN THAT GOAL THEY ALSO HOPE

4351
02:43:11,200 --> 02:43:13,880
TO EXPAND AND DIVERSIFY

4352
02:43:13,880 --> 02:43:14,640
TRANSLATIONAL SCIENCE WORK

4353
02:43:14,640 --> 02:43:15,120
FORCE.

4354
02:43:15,120 --> 02:43:17,360
THE BRANCH AIMES TO ACHIEVE

4355
02:43:17,360 --> 02:43:18,720
THESE GOLDSBY COORDINATING AND

4356
02:43:18,720 --> 02:43:20,720
PROVIDING CENTRAL LEADERSHIP TO

4357
02:43:20,720 --> 02:43:23,440
NCATS TRANSLATIONAL EDUCATION

4358
02:43:23,440 --> 02:43:24,160
ACROSS THE CENTER.

4359
02:43:24,160 --> 02:43:26,880
SO THEY WORK WITH ALL THE CENTER

4360
02:43:26,880 --> 02:43:29,160
DIVISIONS AND OFFICES, IN

4361
02:43:29,160 --> 02:43:31,680
DEVELOPING NEW INITIATIVES LED

4362
02:43:31,680 --> 02:43:33,560
BY THIS BRANCH AND LEADING

4363
02:43:33,560 --> 02:43:35,040
CENTER WIDE AND ALSO LEAVE A

4364
02:43:35,040 --> 02:43:37,080
CENTER WIDE COMMITTEE FOCUSED ON

4365
02:43:37,080 --> 02:43:46,400
TRANSLATIONAL SCIENCE EDUCATION.

4366
02:43:46,400 --> 02:43:48,000
HERE IS AN EXAMPLE OF THE

4367
02:43:48,000 --> 02:43:49,200
ACTIVITIES THEY STOOD UP IN THE

4368
02:43:49,200 --> 02:43:50,040
SHORT TIME THEY HAVE BEEN IN

4369
02:43:50,040 --> 02:43:57,800
EXISTENCE.  THE 501 COURSE IS

4370
02:43:57,800 --> 02:43:59,800
ONLINE COURSE INITIATED BY

4371
02:43:59,800 --> 02:44:01,440
EDUCATION BRANCH AND THIS WAS TO

4372
02:44:01,440 --> 02:44:06,360
BUILD ON EXISTING EFFORTS BY N

4373
02:44:06,360 --> 02:44:07,840
CATS COURSES TO TEACH PRINCIPLES

4374
02:44:07,840 --> 02:44:09,200
OF TRANSLATIONAL SCIENCE.

4375
02:44:09,200 --> 02:44:13,720
THEY ARE WORKING WITH OUR

4376
02:44:13,720 --> 02:44:15,520
COMMUNICATION BRANCH TO IMPRINT

4377
02:44:15,520 --> 02:44:17,400
SOME OF THESE IMPORTANT

4378
02:44:17,400 --> 02:44:21,600
PRINCIPLES IN TERMS OF BADGES TO

4379
02:44:21,600 --> 02:44:23,280
HELP EXEMPLIFY SOME OF THE IDEAS

4380
02:44:23,280 --> 02:44:25,160
AROUND TRANSLATIONAL SCIENCE

4381
02:44:25,160 --> 02:44:26,680
THAT WE THINK NEED TO HAVE A

4382
02:44:26,680 --> 02:44:32,760
PARTICULAR EMPHASIS.

4383
02:44:32,760 --> 02:44:34,680
HERE ARE THINGS WE ARE WORKING

4384
02:44:34,680 --> 02:44:38,280
ON, THIS IS IN DEVELOPMENT, IT

4385
02:44:38,280 --> 02:44:39,440
IS NOT OUT THERE YET BUT THIS IS

4386
02:44:39,440 --> 02:44:40,680
AN EXAMPLE OF THINGS WE ARE

4387
02:44:40,680 --> 02:44:43,800
TALKING ABOUT IN TERMS OF HOW WE

4388
02:44:43,800 --> 02:44:45,000
LOOK AT THE SCIENCE OF

4389
02:44:45,000 --> 02:44:46,440
TRANSLATION AND WHAT THE WORK

4390
02:44:46,440 --> 02:44:48,000
FORCE, WHAT NEED TO BE EXPERT

4391
02:44:48,000 --> 02:44:53,840
GAINED EXPERTISE IN.

4392
02:44:53,840 --> 02:44:55,480
WITH THAT THIS WILL LEAD TO NEW

4393
02:44:55,480 --> 02:44:56,760
CONCEPT CLEARANCE AND I WILL

4394
02:44:56,760 --> 02:45:01,640
HAND THIS OVER TO DR. JESSICA

4395
02:45:01,640 --> 02:45:04,840
BADGER EDUCATION BRANCH CHIEF.

4396
02:45:04,840 --> 02:45:06,520
>> THANK YOU, THIS IS A PROPOSAL

4397
02:45:06,520 --> 02:45:08,440
TO DEVELOP A PORTFOLIO OF

4398
02:45:08,440 --> 02:45:10,360
EXTRAMURAL RESEARCH EDUCATION

4399
02:45:10,360 --> 02:45:11,920
AWARDS THAT RESULT IN A SUITE OF

4400
02:45:11,920 --> 02:45:15,720
ONLINE EDUCATION ACTIVITIES THAT

4401
02:45:15,720 --> 02:45:17,640
CENTER TEACHING EFFECTIVE

4402
02:45:17,640 --> 02:45:21,200
PRACTICES AND CORE PRINCIPLES OF

4403
02:45:21,200 --> 02:45:22,600
TRANSLATIONAL SCIENCE.

4404
02:45:22,600 --> 02:45:24,680
WITH KNOW THERE IS A NEED FOR

4405
02:45:24,680 --> 02:45:26,240
CURRICULAR ACTIVITIES THAT

4406
02:45:26,240 --> 02:45:27,480
DISSEMINATE EFFECTIVE PRACTICES

4407
02:45:27,480 --> 02:45:29,080
AND TRANSLATIONAL SCIENCE BASED

4408
02:45:29,080 --> 02:45:30,880
ON OUR ACTIVITIES INCLUDING

4409
02:45:30,880 --> 02:45:32,080
EXTENSIVE LIT REVIEW AND

4410
02:45:32,080 --> 02:45:33,880
EXPERIENCE WITH OUR INTERNAL

4411
02:45:33,880 --> 02:45:36,920
TRAINING PROGRAM AND MOST

4412
02:45:36,920 --> 02:45:38,040
IMPORTANTLY WE RECEIVED THIS

4413
02:45:38,040 --> 02:45:38,960
FEEDBACK FROM THE COMMUNITY.

4414
02:45:38,960 --> 02:45:42,520
AS YOU HEARD FROM DR. BERRIGAN

4415
02:45:42,520 --> 02:45:46,360
THE EDUCATION BRANCH -- BURGOON

4416
02:45:46,360 --> 02:45:47,480
THROUGH DEVELOPMENT OF TWO ON

4417
02:45:47,480 --> 02:45:48,720
LION COURSES THAT USE EXAMPLES

4418
02:45:48,720 --> 02:45:51,360
OF SUCCESSFUL NCATS LED EFFORTS

4419
02:45:51,360 --> 02:45:53,080
TO DEMONSTRATE HOW SPECIFIC

4420
02:45:53,080 --> 02:45:55,080
RESEARCH ADVANCES CAN BE

4421
02:45:55,080 --> 02:45:57,480
EXAMINED TO OFFER INSIGHT TO

4422
02:45:57,480 --> 02:45:59,160
TRANSLATIONAL PROCESS IDENTIFY

4423
02:45:59,160 --> 02:46:01,240
COMMON CHALLENGES THAT STYMIE

4424
02:46:01,240 --> 02:46:02,800
TRANSLATIONAL PROJECTS AND

4425
02:46:02,800 --> 02:46:04,480
SOLUTIONS THAT ARE APPLICABLE

4426
02:46:04,480 --> 02:46:06,120
NOT ONLY TO THIS PARTICULAR CASE

4427
02:46:06,120 --> 02:46:08,200
BUT ALSO MORE BROADLY TO

4428
02:46:08,200 --> 02:46:09,680
RESEARCH INITIATIVES ACROSS THE

4429
02:46:09,680 --> 02:46:11,880
TRANSLATIONAL SPECTRUM.

4430
02:46:11,880 --> 02:46:13,680
THROUGH EXAMINING CASES N CATS

4431
02:46:13,680 --> 02:46:16,680
STAFF ALSO IDENTIFIED THE SEVEN

4432
02:46:16,680 --> 02:46:18,880
INITIAL PRINCIPLES FOR EFFECTIVE

4433
02:46:18,880 --> 02:46:19,800
TRANSLATIONAL SCIENCE SHARED ON

4434
02:46:19,800 --> 02:46:21,040
THE PRIOR SLIDE AND HAVE BEEN

4435
02:46:21,040 --> 02:46:23,400
INCORPORATED INTO THESE COURSES.

4436
02:46:23,400 --> 02:46:25,240
WE NOW WANT TO EXPAND UPON AND

4437
02:46:25,240 --> 02:46:26,520
EXTEND THIS APPROACH THROUGH

4438
02:46:26,520 --> 02:46:27,800
STIMULATING ADDITIONAL

4439
02:46:27,800 --> 02:46:29,680
TRANSLATIONAL SCIENCE EDUCATION

4440
02:46:29,680 --> 02:46:31,120
ACTIVITIES, OR WE CAN CALL THESE

4441
02:46:31,120 --> 02:46:33,680
EDUCATION EXPERIMENTS, THAT

4442
02:46:33,680 --> 02:46:35,440
FURTHER DEVELOP AND FORMALIZE

4443
02:46:35,440 --> 02:46:36,680
TRANSLATIONAL SCIENCE FOR

4444
02:46:36,680 --> 02:46:38,800
CONCEPTS APPROACHES AND

4445
02:46:38,800 --> 02:46:40,520
STRATEGIES DERIVED FROM THE

4446
02:46:40,520 --> 02:46:41,120
EXPERIENTIAL KNOWLEDGE IN THE

4447
02:46:41,120 --> 02:46:42,360
FIELD.

4448
02:46:42,360 --> 02:46:44,480
WE ALSO WANT TO DO THIS WITH AN

4449
02:46:44,480 --> 02:46:45,920
EYE TOWARDS EXPANDING

4450
02:46:45,920 --> 02:46:50,240
TRANSLATIONAL SCIENCE WORK FORCE

4451
02:46:50,240 --> 02:46:51,280
ENHANCING WORK FORCE DIVERSITY

4452
02:46:51,280 --> 02:46:52,280
ENSURING BROAD ACCESS TO

4453
02:46:52,280 --> 02:46:53,840
ACTIVITIES AS WELL AS

4454
02:46:53,840 --> 02:46:54,880
ENCOURAGING INNOVATION AND

4455
02:46:54,880 --> 02:46:56,240
ONLINE TRANSLATIONAL SCIENCE

4456
02:46:56,240 --> 02:47:00,720
EDUCATION.

4457
02:47:00,720 --> 02:47:02,200
THESE AWARDS FUND FULL CYCLE

4458
02:47:02,200 --> 02:47:03,160
FROM DEVELOPMENT TO

4459
02:47:03,160 --> 02:47:04,840
IMPLEMENTATION TO EVALUATION OF

4460
02:47:04,840 --> 02:47:09,680
THESE EDUCATIONAL ACTIVITIES.

4461
02:47:09,680 --> 02:47:11,760
THIS PROPOSAL ALIGNS WITH TWO

4462
02:47:11,760 --> 02:47:13,760
NCATS STRATEGIC GOALS, THAT IS

4463
02:47:13,760 --> 02:47:15,000
ADVANCING TRANSLATIONAL SCIENCE

4464
02:47:15,000 --> 02:47:16,760
BY UNCOVERING TRANSLATIONAL

4465
02:47:16,760 --> 02:47:18,680
SCIENCE PRINCIPLES TO CATALYZE

4466
02:47:18,680 --> 02:47:21,760
ADVANCES IN HEALTH INTERVENTIONS

4467
02:47:21,760 --> 02:47:23,440
SO UNCOVERING PRINCIPLES AND

4468
02:47:23,440 --> 02:47:25,320
TEACHING THOSE TO CURRENT FUTURE

4469
02:47:25,320 --> 02:47:26,560
MEMBERS OF THE TRANSLATIONAL

4470
02:47:26,560 --> 02:47:27,880
SCIENCE WORK FORCE.

4471
02:47:27,880 --> 02:47:31,840
AND TO DO THAT, MEET STREAM GOAL

4472
02:47:31,840 --> 02:47:34,880
THREE DEVELOPING FOSTERING

4473
02:47:34,880 --> 02:47:36,240
INNOVATIVE TRANSLATIONAL SCIENCE

4474
02:47:36,240 --> 02:47:37,760
TRAINING AND HIGHLY SKILLED

4475
02:47:37,760 --> 02:47:39,480
CREATIVE AND DIVERSE

4476
02:47:39,480 --> 02:47:40,040
TRANSLATIONAL SCIENCE WORK

4477
02:47:40,040 --> 02:47:40,880
FORCE.

4478
02:47:40,880 --> 02:47:43,400
WE REALLY SEE THIS AUGMENTING

4479
02:47:43,400 --> 02:47:45,200
CURRENT EDUCATION TRAINING

4480
02:47:45,200 --> 02:47:46,160
PROGRAMS.

4481
02:47:46,160 --> 02:47:47,360
WE KNOW SOME CURRENT ACTIVITIES

4482
02:47:47,360 --> 02:47:49,240
FOCUS ON THE CHARACTERISTICS OF

4483
02:47:49,240 --> 02:47:52,320
THE TRANSLATIONAL SCIENCE BEING

4484
02:47:52,320 --> 02:47:55,240
SKILLED COMMUNICATOR, DISTINCT

4485
02:47:55,240 --> 02:47:57,320
PHASES OF TRANSLATION OR CONTENT

4486
02:47:57,320 --> 02:47:58,720
AREAS RELATED TO TRANSLATION.

4487
02:47:58,720 --> 02:48:00,880
BUT NOW WE WANT TO ADD TO THIS

4488
02:48:00,880 --> 02:48:03,120
HOW DO WE EXPLORE TRANSLATIONAL

4489
02:48:03,120 --> 02:48:04,680
SCIENCE BY LOOKING AT THE WHOLE

4490
02:48:04,680 --> 02:48:05,080
SYSTEM.

4491
02:48:05,080 --> 02:48:06,880
HOW DO WE IDENTIFY THESE

4492
02:48:06,880 --> 02:48:08,240
EFFECTIVE PRACTICES AND TEACH

4493
02:48:08,240 --> 02:48:10,480
THEM TO OTHERS, AND ARTICULATE

4494
02:48:10,480 --> 02:48:12,240
THE BENEFITS OF A TRANSLATIONAL

4495
02:48:12,240 --> 02:48:13,480
SCIENCE APPROACH.

4496
02:48:13,480 --> 02:48:21,520
AND USING THESE PRINCIPLES COULD

4497
02:48:21,520 --> 02:48:23,480
INVESTIGATE A SCIENCE MIND SET.

4498
02:48:23,480 --> 02:48:24,680
THIS IS ESTABLISHING

4499
02:48:24,680 --> 02:48:25,280
TRANSLATIONAL SCIENCE AS

4500
02:48:25,280 --> 02:48:28,480
DISTINCT AREA OF STUDY.

4501
02:48:28,480 --> 02:48:30,960
SO I MENTION WE HAVE DONE LIT

4502
02:48:30,960 --> 02:48:32,400
REVIEW, I WILL SHARE ABOUT THE

4503
02:48:32,400 --> 02:48:33,800
DATA HERE AS IT IS INFORMED OUR

4504
02:48:33,800 --> 02:48:35,160
THINKING ON THIS.

4505
02:48:35,160 --> 02:48:38,760
BUT WE WERE SPECIFICALLY LOOKING

4506
02:48:38,760 --> 02:48:39,480
AT TRANSLATIONAL SCIENCE

4507
02:48:39,480 --> 02:48:41,160
EDUCATION WHERE THERE WAS FORMAL

4508
02:48:41,160 --> 02:48:44,720
CURRICULUM COMPONENT, EDUCATION

4509
02:48:44,720 --> 02:48:46,840
OR COURSE, A WORKSHOP, SEMINAR

4510
02:48:46,840 --> 02:48:50,040
SERIES AND THEN WHAT WAS TAUGHT

4511
02:48:50,040 --> 02:48:51,920
OR CONVEYED WITHIN THOSE COURSES

4512
02:48:51,920 --> 02:48:56,160
WORKSHOPS, ET CETERA.

4513
02:48:56,160 --> 02:48:58,480
THIS IS SHOWING YOU CAN IMAGINE

4514
02:48:58,480 --> 02:48:59,720
LIT REVIEW FOR TRANSLATIONAL

4515
02:48:59,720 --> 02:49:02,680
SCIENCE EDUCATION YOU GET

4516
02:49:02,680 --> 02:49:04,880
ARTICLES WHEN YOU NARROW DOWN

4517
02:49:04,880 --> 02:49:06,320
SPECIFIC CURRICULUM COMPONENTS

4518
02:49:06,320 --> 02:49:09,480
IT BECOMES FEW ARTICLES IN THE

4519
02:49:09,480 --> 02:49:12,000
LITERATURE OVER THE SPAN WE LOOK

4520
02:49:12,000 --> 02:49:16,760
AT FROM ABOUT 2005 THROUGH 2021.

4521
02:49:16,760 --> 02:49:18,320
BASICALLY THE TAKE HOME MESSAGE

4522
02:49:18,320 --> 02:49:19,480
IN THESE SLIDES THERE ARE

4523
02:49:19,480 --> 02:49:20,920
CERTAIN SEGMENTS OF

4524
02:49:20,920 --> 02:49:21,720
TRANSLATIONAL SCIENCE WORK FORCE

4525
02:49:21,720 --> 02:49:24,400
WE ARE MISSING OR PEOPLE WHO WE

4526
02:49:24,400 --> 02:49:26,720
WANTS BRING INTO THE WORK FORCE.

4527
02:49:26,720 --> 02:49:27,960
AGAIN THIS WAS PRE-COVID WE KNOW

4528
02:49:27,960 --> 02:49:29,960
A LOT HAPPENED WITH ONLINE

4529
02:49:29,960 --> 02:49:33,000
EDUCATION IN THIS TIME.

4530
02:49:33,000 --> 02:49:35,760
THERE WAS -- THERE WAS FEW

4531
02:49:35,760 --> 02:49:37,200
ARTICLES MENTIONED ANYTHING

4532
02:49:37,200 --> 02:49:39,880
ABOUT ONLINE COMPONENT.

4533
02:49:39,880 --> 02:49:43,000
FROM OUR LITERATURE RESEARCH.

4534
02:49:43,000 --> 02:49:50,280
WE ALSO ORGANIZED ARTICLES BASED

4535
02:49:50,280 --> 02:49:52,320
ON FRAME WORK OF TRANSLATIONAL

4536
02:49:52,320 --> 02:49:54,240
PRINCIPLES TO SEE WHERE GAPS OR

4537
02:49:54,240 --> 02:49:55,880
ADDITIONAL EDUCATION NEEDS COULD

4538
02:49:55,880 --> 02:49:57,160
EXIST AND AGAIN THIS SHOWS YOU

4539
02:49:57,160 --> 02:49:59,400
THERE'S SOME THINGS THAT WE ARE

4540
02:49:59,400 --> 02:50:04,480
TOUCHING ON FREQUENTLY LIKE TEAM

4541
02:50:04,480 --> 02:50:06,040
SCIENCE BUT OTHER THINGS WE CAN

4542
02:50:06,040 --> 02:50:09,600
BUILD OUT MORE.

4543
02:50:09,600 --> 02:50:10,720
SO GIVE YOU SOME OF THE

4544
02:50:10,720 --> 02:50:12,000
HIGHLIGHTS FOR THIS PROPOSAL,

4545
02:50:12,000 --> 02:50:14,120
WHAT WE ARE PROPOSING IS FUNDING

4546
02:50:14,120 --> 02:50:15,800
OPPORTUNITY FOR THE EXTRAMURAL

4547
02:50:15,800 --> 02:50:18,000
COMMUNITY TO DEVELOP NEW

4548
02:50:18,000 --> 02:50:19,200
EDUCATION OPPORTUNITIES TEACHING

4549
02:50:19,200 --> 02:50:21,760
CORE TRANSLATIONAL SCIENCE

4550
02:50:21,760 --> 02:50:23,680
CONCEPT, INCLUDING SCIENTIFIC

4551
02:50:23,680 --> 02:50:24,760
OPERATIONAL PRINCIPLES KEY

4552
02:50:24,760 --> 02:50:26,640
STRATEGIES AND APPROACHES USED

4553
02:50:26,640 --> 02:50:28,880
EFFECTIVELY TO ADVANCE

4554
02:50:28,880 --> 02:50:30,520
TRANSLATION LOOKING FOR THIS TO

4555
02:50:30,520 --> 02:50:32,640
EXPAND AND DIVERSIFY

4556
02:50:32,640 --> 02:50:33,640
TRANSLATIONAL SCIENCE WORK FORCE

4557
02:50:33,640 --> 02:50:36,080
TO REACH PEOPLE NOT CURRENTLY

4558
02:50:36,080 --> 02:50:37,440
REACHING WITH OUR CURRENT

4559
02:50:37,440 --> 02:50:39,200
EDUCATION TRAINING PROGRAMS AND

4560
02:50:39,200 --> 02:50:40,960
WE REALLY WANT TO STIMULATE

4561
02:50:40,960 --> 02:50:42,800
INNOVATION AND EDUCATION CONTENT

4562
02:50:42,800 --> 02:50:43,560
DESIGN.

4563
02:50:43,560 --> 02:50:45,240
SO WHILE WE WANT THIS AVAILABLE

4564
02:50:45,240 --> 02:50:49,880
IN AN ONLINE FORMAT WE ARE NOT

4565
02:50:49,880 --> 02:50:51,880
FOCUSED IN ON THIS HAS TO BE

4566
02:50:51,880 --> 02:50:54,680
TYPICAL ON LINE COURSE, THERE'S

4567
02:50:54,680 --> 02:50:56,680
WAYS THIS CONTENT COULD BE

4568
02:50:56,680 --> 02:50:57,080
DELIVERED.

4569
02:50:57,080 --> 02:50:58,280
KEY PART OF THIS WILL BE

4570
02:50:58,280 --> 02:51:01,000
EVALUATION.

4571
02:51:01,000 --> 02:51:02,960
WE WANT THESE EDUCATION

4572
02:51:02,960 --> 02:51:04,480
ACTIVITIES EVALUATED TO USE TO

4573
02:51:04,480 --> 02:51:06,040
ESTABLISH EVIDENCE BASED FOR

4574
02:51:06,040 --> 02:51:08,160
EFFECTIVE APPROACHES IN TEACHING

4575
02:51:08,160 --> 02:51:11,280
TRANSLATIONAL SCIENCE CONCEPTS. 

4576
02:51:11,280 --> 02:51:12,760
SO AT NCATS WE SAY EVERYTHING IS

4577
02:51:12,760 --> 02:51:14,400
AN EXPERIMENT WE ARE NOT AFRAID

4578
02:51:14,400 --> 02:51:15,680
FOR THIS TO BE AN EXPERIMENT AND

4579
02:51:15,680 --> 02:51:21,520
FOR US TO LEARN WHAT WORKS.

4580
02:51:21,520 --> 02:51:23,240
THE NEXT SLIDE SPEAKS MORE TO

4581
02:51:23,240 --> 02:51:24,120
SOME OF THE THINGS WE WOULD LIKE

4582
02:51:24,120 --> 02:51:26,240
TO SEE COLLECTED AS THE

4583
02:51:26,240 --> 02:51:27,560
EVALUATION COMPONENT.

4584
02:51:27,560 --> 02:51:29,160
THAT INCLUDES DIVERSITY OF THE

4585
02:51:29,160 --> 02:51:32,240
PARTICIPANTS IN THESE EDUCATION

4586
02:51:32,240 --> 02:51:33,560
ACTIVITIES AND DIVERSITY IN ALL

4587
02:51:33,560 --> 02:51:36,680
AREAS TRAINING AND CAREER STAGE,

4588
02:51:36,680 --> 02:51:40,720
EMPLOYMENT SECTOR GENDER RACE

4589
02:51:40,720 --> 02:51:43,160
ETHNICITY INSTITUTION TYPE

4590
02:51:43,160 --> 02:51:45,480
GEOGRAPHY WE WANT TO KNOW

4591
02:51:45,480 --> 02:51:46,360
ADHERENCE OR DEGREE OF

4592
02:51:46,360 --> 02:51:47,760
PARTICIPATION IN A COURSE, THAT

4593
02:51:47,760 --> 02:51:48,520
WOULD BE IMPORTANT.

4594
02:51:48,520 --> 02:51:51,040
FOR THEM TAKING THIS TO THE NEXT

4595
02:51:51,040 --> 02:51:51,880
LEVEL AND UNDERSTANDING HOW

4596
02:51:51,880 --> 02:51:54,480
PEOPLE ARE UTILIZING THIS

4597
02:51:54,480 --> 02:51:55,600
KNOWLEDGE AND HOW DOES IT

4598
02:51:55,600 --> 02:51:56,840
INFLUENCE THEIR RESEARCH OR

4599
02:51:56,840 --> 02:52:02,920
CAREER GOALS GOING FORWARD.

4600
02:52:02,920 --> 02:52:04,800
SO WHAT DO WE EXPECT AN OUTCOME

4601
02:52:04,800 --> 02:52:09,520
FROM THIS EDUCATION PROGRAM?

4602
02:52:09,520 --> 02:52:11,240
BROADEN EXPAND FOUNDATIONAL

4603
02:52:11,240 --> 02:52:13,280
TRANSLATIONAL SCIENCE KNOWLEDGE.

4604
02:52:13,280 --> 02:52:15,600
DOING THROUGH VARIETY OF ONLINE

4605
02:52:15,600 --> 02:52:17,080
EDUCATION ACTIVITIES TO INCREASE

4606
02:52:17,080 --> 02:52:18,680
UNDERSTANDING OF TRANSLATIONAL

4607
02:52:18,680 --> 02:52:20,880
SCIENCE PRINCIPLES AND EFFECTIVE

4608
02:52:20,880 --> 02:52:21,880
APPROACHES AND TRANSLATIONAL

4609
02:52:21,880 --> 02:52:23,480
SCIENCE.

4610
02:52:23,480 --> 02:52:26,120
WE KNOW ONLINE LEARNING ONLINE

4611
02:52:26,120 --> 02:52:27,480
EDUCATION ACTIVITIES ARE HERE TO

4612
02:52:27,480 --> 02:52:29,160
STAY, PEOPLE APPRECIATE THE

4613
02:52:29,160 --> 02:52:33,960
FLEXIBILITY OF THIS, THEY

4614
02:52:33,960 --> 02:52:35,440
APPRECIATE ACCESSIBILITY, SO WE

4615
02:52:35,440 --> 02:52:37,800
WANT TO MAXIMIZE ONLINE LEARNING

4616
02:52:37,800 --> 02:52:39,480
AND EVALUATE THIS TO LEAD TO

4617
02:52:39,480 --> 02:52:41,280
EVIDENCE INFORMED TEACHING

4618
02:52:41,280 --> 02:52:41,920
APPROACHES FOR ONLINE EDUCATION

4619
02:52:41,920 --> 02:52:43,720
AND TRANSLATIONAL SCIENCE

4620
02:52:43,720 --> 02:52:45,040
REACHING DIVERSE AUDIENCE OF

4621
02:52:45,040 --> 02:52:45,720
LEARNERS.

4622
02:52:45,720 --> 02:52:48,720
WE WANT TO CATALYZE NEW

4623
02:52:48,720 --> 02:52:49,560
TRANSLATIONAL SCIENCE CURRICULA.

4624
02:52:49,560 --> 02:52:53,000
SO ULTIMATELY THESE EDUCATION

4625
02:52:53,000 --> 02:52:54,000
OPPORTUNITIES OR ACTIVITIES

4626
02:52:54,000 --> 02:52:55,840
SHOWN TO BE EFFECTIVE COULD BE

4627
02:52:55,840 --> 02:52:58,440
INFORM RATED INTO A WIDE RANGE

4628
02:52:58,440 --> 02:53:00,680
OF BIOMEDICAL RESEARCH AND

4629
02:53:00,680 --> 02:53:01,920
TRAINING, RESEARCH EDUCATION AND

4630
02:53:01,920 --> 02:53:03,400
TRAINING PROGRAMS INCLUDING

4631
02:53:03,400 --> 02:53:07,480
THOSE FUNDED BY NCATS BUT MORE

4632
02:53:07,480 --> 02:53:11,280
BROADLY, ACROSS NIH.

4633
02:53:11,280 --> 02:53:13,640
IN SUMMARY THIS PROPOSAL WILL

4634
02:53:13,640 --> 02:53:15,440
ADVANCE TRANSLATIONAL SCIENCE

4635
02:53:15,440 --> 02:53:16,560
EDUCATION FOR DEVELOPMENT

4636
02:53:16,560 --> 02:53:22,360
IMPLEMENTATION AND EVALUATION OF

4637
02:53:22,360 --> 02:53:24,360
ONLINE EDUCATION ACTIVITIES

4638
02:53:24,360 --> 02:53:25,520
UNDERSTANDING TRANSLATIONAL

4639
02:53:25,520 --> 02:53:26,200
SCIENCE PRINCIPLES AN

4640
02:53:26,200 --> 02:53:27,480
APPLICATION TO RESEARCH ACROSS

4641
02:53:27,480 --> 02:53:28,600
THE TRANSLATIONAL SCIENCE

4642
02:53:28,600 --> 02:53:29,040
SPECTRUM.

4643
02:53:29,040 --> 02:53:35,280
NOW IS THE TIME TO AGGREGATE

4644
02:53:35,280 --> 02:53:36,000
THIS EXPERIENCIAL KNOWLEDGE WE

4645
02:53:36,000 --> 02:53:37,360
AMASS AND WE HEARD ABOUT MANY OF

4646
02:53:37,360 --> 02:53:39,600
THESE ADVANCES AT OUR TENTH

4647
02:53:39,600 --> 02:53:40,600
ANNIVERSARY AND WE KNOW THERE

4648
02:53:40,600 --> 02:53:44,720
ARE MORE THAN THAT TO DRAW ON.

4649
02:53:44,720 --> 02:53:46,640
TIME TO EXPANDS TRANSLATIONAL

4650
02:53:46,640 --> 02:53:48,480
SCIENCE KNOWLEDGE BASE AND

4651
02:53:48,480 --> 02:53:49,200
CONDITION SRI TO BROAD RANGE OF

4652
02:53:49,200 --> 02:53:50,720
INDIVIDUALS TO EXPAND AND

4653
02:53:50,720 --> 02:53:54,280
DIVERSIFY THE WORK FORCE AND

4654
02:53:54,280 --> 02:53:55,840
STIMULATE INNOVATION AND

4655
02:53:55,840 --> 02:53:56,880
TRANSLATIONAL SCIENCE EDUCATION

4656
02:53:56,880 --> 02:53:58,480
AND HOW WE ARE DEVELOPING THAT

4657
02:53:58,480 --> 02:53:58,840
FORCE.

4658
02:53:58,840 --> 02:54:00,680
ON THE NEXT SLIDE I WILL

4659
02:54:00,680 --> 02:54:02,920
TRANSITION TO TAKING QUESTIONS

4660
02:54:02,920 --> 02:54:06,840
AND COMMENTS FROM THE COUNCIL,

4661
02:54:06,840 --> 02:54:07,880
COUNCIL MEMBERS WE LOOK FORWARD

4662
02:54:07,880 --> 02:54:09,880
TO HEARING FROM YOU WHAT IMPROVE

4663
02:54:09,880 --> 02:54:11,000
THE INITIATIVE AND OTHER THINGS

4664
02:54:11,000 --> 02:54:12,880
WE SHOULD BE CONSIDERING.

4665
02:54:12,880 --> 02:54:15,240
>> JESSICA, BEFORE YOU MOVE ON

4666
02:54:15,240 --> 02:54:17,920
WE HAVE COUPLE OF COUNCIL

4667
02:54:17,920 --> 02:54:19,480
MEMBERS DISCUSSANTS FOR THIS

4668
02:54:19,480 --> 02:54:20,080
CONCEPT.

4669
02:54:20,080 --> 02:54:23,360
I WILL LET BEBECKY GO FIRST AND

4670
02:54:23,360 --> 02:54:24,720
RAJESH AFTER THAT AND HEAR YOUR

4671
02:54:24,720 --> 02:54:26,520
THOUGHTS AND WE WILL OPEN FOR

4672
02:54:26,520 --> 02:54:27,760
BROADER DISCUSSION.

4673
02:54:27,760 --> 02:54:29,240
BECKY, LEAD US OFF?

4674
02:54:29,240 --> 02:54:32,080
>> THANKS, JONI.

4675
02:54:32,080 --> 02:54:34,080
I LIKE TO START THIS OFF BY

4676
02:54:34,080 --> 02:54:37,680
SAYING THAT I'M INCREDIBLY

4677
02:54:37,680 --> 02:54:40,600
ENTHUSIASTIC ABOUT SEEING REALLY

4678
02:54:40,600 --> 02:54:43,560
LEVERAGE OF BROADER EXTRAMURAL

4679
02:54:43,560 --> 02:54:45,680
COMMUNITY, THAT INCLUDES PUBLIC

4680
02:54:45,680 --> 02:54:48,680
PRIVATE PARTNERSHIPS AND OTHERS

4681
02:54:48,680 --> 02:54:52,440
THAT CAN PULL TOGETHER BOTH

4682
02:54:52,440 --> 02:54:54,280
BASIC AS WELL AS MORE ADVANCE

4683
02:54:54,280 --> 02:54:57,520
TRAINING IN THE UNDERLYING

4684
02:54:57,520 --> 02:54:58,280
PRINCIPLES OF TRANSLATIONAL

4685
02:54:58,280 --> 02:55:00,680
SCIENCE AND REALLY SHARING

4686
02:55:00,680 --> 02:55:02,560
WITHIN THAT SOME OF THE TOOLS

4687
02:55:02,560 --> 02:55:04,040
THAT WE CAN UTILIZE FOR DOING

4688
02:55:04,040 --> 02:55:06,000
THAT.

4689
02:55:06,000 --> 02:55:08,880
I DO THINK IT IS IMPORTANT

4690
02:55:08,880 --> 02:55:11,200
SHOULD BE EMPHASIZED THAT THIS

4691
02:55:11,200 --> 02:55:14,160
SHOULD REALLY SUPPORT THAT FULL

4692
02:55:14,160 --> 02:55:17,360
SPECTRUM OF TRANSLATIONAL

4693
02:55:17,360 --> 02:55:18,840
SCIENCE REALLY FROM TAKING

4694
02:55:18,840 --> 02:55:20,480
DISCOVERY TO THE BEDSIDE ALL THE

4695
02:55:20,480 --> 02:55:25,040
WAY INTO DISSEMINATION AND

4696
02:55:25,040 --> 02:55:27,280
IMPLEMENTATION SCIENCE BUT THERE

4697
02:55:27,280 --> 02:55:28,840
ARE COUPLE OF THINGS THAT I

4698
02:55:28,840 --> 02:55:33,360
THINK COULD IMPROVE THIS I HAVE

4699
02:55:33,360 --> 02:55:34,840
A COUPLE OF SUGGESTIONS TO

4700
02:55:34,840 --> 02:55:35,720
RESPOND TO.

4701
02:55:35,720 --> 02:55:37,680
THE FIRST I THINK IS THAT AS THE

4702
02:55:37,680 --> 02:55:40,200
FIELD OF TRANSLATIONAL SCIENCE

4703
02:55:40,200 --> 02:55:43,720
CONTINUES TO EXPAND AND AS WE

4704
02:55:43,720 --> 02:55:47,960
GET MORE CLARITY AROUND SOME OF

4705
02:55:47,960 --> 02:55:50,240
THE THINGS THAT WILL ADVANCE

4706
02:55:50,240 --> 02:55:52,840
GOALS THAT HAD BEEN TALKED ABOUT

4707
02:55:52,840 --> 02:55:55,160
TODAY I THINK THAT IS GOING TO

4708
02:55:55,160 --> 02:56:03,120
BE CRITICAL THAT ANY TYPE OF ON

4709
02:56:03,120 --> 02:56:05,680
LION OPPORTUNITIES ARE KEPT UP

4710
02:56:05,680 --> 02:56:11,600
TO DAY SO HAVING THAT

4711
02:56:11,600 --> 02:56:14,160
SUSTAINABILITSUSTAINABILITY PLAN
REVIEW AN
D

4712
02:56:14,160 --> 02:56:16,760
UPDATE OF MATERIALS OR SUN

4713
02:56:16,760 --> 02:56:18,680
DOWNING THEM AT SPECIFIC PERIODS

4714
02:56:18,680 --> 02:56:20,480
OF TIME ARE CRITICAL IN ORDER

4715
02:56:20,480 --> 02:56:24,080
FOR THIS TO ACTUALLY HAVE A

4716
02:56:24,080 --> 02:56:24,840
SIGNIFICANT IMPACT.

4717
02:56:24,840 --> 02:56:26,480
I THINK THE SECOND THING WHICH

4718
02:56:26,480 --> 02:56:32,760
YOU MENTIONED IN YOUR SLIDE,

4719
02:56:32,760 --> 02:56:35,680
REALLY TO INNOVATE CURRICULAR

4720
02:56:35,680 --> 02:56:36,880
YOU KNOWVATION AND I USE THIS AS

4721
02:56:36,880 --> 02:56:38,200
A OPPORTUNITY TO SEE WHICH

4722
02:56:38,200 --> 02:56:39,440
APPROACHES ARE MOST EFFECTIVE

4723
02:56:39,440 --> 02:56:43,840
FOR ADULT LEARNERS IN TERMS OF

4724
02:56:43,840 --> 02:56:46,680
ACTUALLY CHANGING BEHAVIOR AND

4725
02:56:46,680 --> 02:56:49,400
CULTURE AND BEING MORE ENGAGED

4726
02:56:49,400 --> 02:56:51,600
AND TRANSLATIONAL SCIENCE

4727
02:56:51,600 --> 02:56:52,480
APPROACHES.

4728
02:56:52,480 --> 02:56:54,880
SO ONE OF THE PROBLEMS AS ALL OF

4729
02:56:54,880 --> 02:56:59,280
US KNOW WHO CREATED ONLINE

4730
02:56:59,280 --> 02:57:00,920
LEARNING, IS THAT IT DOES NOT

4731
02:57:00,920 --> 02:57:02,400
FOLLOW THE FIELD OF DREAMS WHICH

4732
02:57:02,400 --> 02:57:04,200
YOU TALKED ABOUT EARLIER SO JUST

4733
02:57:04,200 --> 02:57:05,400
BECAUSE YOU BUILD IT DOESN'T

4734
02:57:05,400 --> 02:57:08,000
MEAN PEOPLE WILL COME.

4735
02:57:08,000 --> 02:57:10,000
IT IS IMPORTANT WE THINK ABOUT

4736
02:57:10,000 --> 02:57:11,240
REALLY COMING UP WITH MORE

4737
02:57:11,240 --> 02:57:13,280
ENGAGING APPROACHES, AND

4738
02:57:13,280 --> 02:57:16,640
INNOVATIVE APPROACHES WHETHER

4739
02:57:16,640 --> 02:57:19,640
THIS IMPLICATION CASE STUDIES,

4740
02:57:19,640 --> 02:57:23,160
EXTENDED MORE IN DEPTH READINGS

4741
02:57:23,160 --> 02:57:25,080
ASSOCIATED WITH THIS OR OTHER

4742
02:57:25,080 --> 02:57:26,400
TYPES OF ACTIVITIES THAT COULD

4743
02:57:26,400 --> 02:57:29,920
BE PURSUED THAT WILL TAKE THAT

4744
02:57:29,920 --> 02:57:31,840
LEVEL FROM BASIC TO NEXT LEVEL

4745
02:57:31,840 --> 02:57:34,480
MASTERY ALL THE WAY TO ADVANCE.

4746
02:57:34,480 --> 02:57:36,360
ONE OF THE THINGS TO THINK ABOUT

4747
02:57:36,360 --> 02:57:39,280
THIS IS YOU ALSO WANT TO SUPPORT

4748
02:57:39,280 --> 02:57:41,040
OTHER ASSOCIATED ACTIVITIES.

4749
02:57:41,040 --> 02:57:42,600
SO DISCUSSION FORMS PEOPLE WHO

4750
02:57:42,600 --> 02:57:45,960
ARE INVOLVED IN THIS, OR WAYS OF

4751
02:57:45,960 --> 02:57:48,600
STARTING TO DEVELOP A COMMUNITY

4752
02:57:48,600 --> 02:57:52,120
OF PRACTICE OR WAYS TO FURTHER

4753
02:57:52,120 --> 02:57:52,760
EXPAND THE FIELD.

4754
02:57:52,760 --> 02:57:57,280
I THINK THE OTHER THINGS THEN IS

4755
02:57:57,280 --> 02:58:01,560
TO THINK ABOUT HOW DO WE REALLY

4756
02:58:01,560 --> 02:58:03,480
DRIVE SUCCESS OF THIS.

4757
02:58:03,480 --> 02:58:07,200
I THINK IT WOULD BE WORTHWHILE

4758
02:58:07,200 --> 02:58:09,760
IN THIS IS RATHER THAN ASKING OR

4759
02:58:09,760 --> 02:58:13,000
HAVING A MEETING JUST BETWEEN

4760
02:58:13,000 --> 02:58:14,880
THOSE THAT ARE FUNDED IS TO

4761
02:58:14,880 --> 02:58:16,320
REALLY THINK ABOUT WHETHER IT

4762
02:58:16,320 --> 02:58:20,600
MIGHT BE MORE NIMBLE COST

4763
02:58:20,600 --> 02:58:26,080
EFFECTIVE AND GET YOU REALLY

4764
02:58:26,080 --> 02:58:28,520
MORE SIGNIFICANT RESULTS IF YOU

4765
02:58:28,520 --> 02:58:31,880
CONSIDER THIS AS MORE FORMALIZED

4766
02:58:31,880 --> 02:58:34,480
CONSORTIA WHERE YOU BRING

4767
02:58:34,480 --> 02:58:37,440
TOGETHER AND MAKE SOME LEVEL OF

4768
02:58:37,440 --> 02:58:39,320
CONSISTENCY OF STRUCTURE.

4769
02:58:39,320 --> 02:58:41,400
YOU CAN DO THIS THEN THROUGH

4770
02:58:41,400 --> 02:58:44,080
PORTAL, DEVELOPMENT OF

4771
02:58:44,080 --> 02:58:45,280
EDUCATIONAL ONTOLOGIES THAT

4772
02:58:45,280 --> 02:58:50,320
ALLOW PEOPLE TO FIND BOTH

4773
02:58:50,320 --> 02:58:51,480
CONTENT THAT BEST MET THEIR

4774
02:58:51,480 --> 02:58:53,920
NEEDS AT THE TIME THEY HAD THEM

4775
02:58:53,920 --> 02:58:56,360
AS WELL AS MARKETING AND

4776
02:58:56,360 --> 02:58:59,520
COMMUNICATION PLANS THAT DRIVE

4777
02:58:59,520 --> 02:59:02,800
TO THE RESOURCE AND CONSISTENT

4778
02:59:02,800 --> 02:59:04,920
AND ACTIONABLE EVALUATION PLAN

4779
02:59:04,920 --> 02:59:08,800
SO YOU ARE COMPARING ACROSS ALL

4780
02:59:08,800 --> 02:59:09,640
THE DIFFERENT PROGRAMS THE SAME

4781
02:59:09,640 --> 02:59:11,840
KIND OF EVALUATION IN TERMS OF

4782
02:59:11,840 --> 02:59:13,960
LOOKING AT LONG TERM IMPACT.

4783
02:59:13,960 --> 02:59:16,120
SO DOES THAT CHANGE LEVEL OF

4784
02:59:16,120 --> 02:59:18,880
TRAJECTORY OR ENGAGEMENT OF

4785
02:59:18,880 --> 02:59:20,960
RESEARCH TRANSLATION, ARE MOVING

4786
02:59:20,960 --> 02:59:23,280
THE FIELD MORE RAPIDLY AND ARE

4787
02:59:23,280 --> 02:59:24,280
WE BEING MORE EFFICIENT.

4788
02:59:24,280 --> 02:59:26,280
I THINK IF YOU THINK ABOUT

4789
02:59:26,280 --> 02:59:27,520
EXPANDING THIS PROGRAM BEYOND

4790
02:59:27,520 --> 02:59:29,880
JUST THE SERIES OF ON LINE

4791
02:59:29,880 --> 02:59:33,720
COURSES TO REALLY SERIES OF

4792
02:59:33,720 --> 02:59:39,880
ONLINE ENGAGING ACTIVITIES, AND

4793
02:59:39,880 --> 02:59:44,160
LEARNING BETWEEN DIFFERENT

4794
02:59:44,160 --> 02:59:45,480
FUNDED PROGRAMS YOU WILL HAVE

4795
02:59:45,480 --> 02:59:48,240
GREATER IMPACT ON THE

4796
02:59:48,240 --> 02:59:51,080
TRANSLATIONAL SCIENCE WORK FORCE

4797
02:59:51,080 --> 02:59:53,680
AND SIMILARLY CAN REALLY THEN

4798
02:59:53,680 --> 02:59:57,280
FOCUS ON APPROACHES THAT ALSO

4799
02:59:57,280 --> 03:00:00,080
ENHANCE DIVERSITY AND INCLUSION

4800
03:00:00,080 --> 03:00:07,240
MULTIPLE PERSPECTIVES AS WELL AS

4801
03:00:07,240 --> 03:00:07,640
INDIVIDUALS.

4802
03:00:07,640 --> 03:00:10,000
>> THANK YOU, THOSE ARE ALL

4803
03:00:10,000 --> 03:00:11,720
FANTASTIC COMMENTS, THINGS WE

4804
03:00:11,720 --> 03:00:15,120
CAN REALLY TAKE TO HEART AS WE

4805
03:00:15,120 --> 03:00:16,480
CRAFT MORE SPECIFIC LANGUAGE.

4806
03:00:16,480 --> 03:00:20,280
I REALLY APPRECIATE YOUR POINT

4807
03:00:20,280 --> 03:00:22,680
TO HAVE OUTCOMES WE NEED PEOPLE

4808
03:00:22,680 --> 03:00:24,840
TO BE ENGAGED HOW DO WE ENHANCE

4809
03:00:24,840 --> 03:00:29,280
THAT ENGAGEMENT.

4810
03:00:29,280 --> 03:00:31,600
>> THANK YOU, RAJESH NEXT

4811
03:00:31,600 --> 03:00:32,200
PLEASE.

4812
03:00:32,200 --> 03:00:32,840
>> SURE.

4813
03:00:32,840 --> 03:00:34,320
JESSICA I'M SORRY WE DIDN'T HAVE

4814
03:00:34,320 --> 03:00:36,320
A CHANCE TO MEET EARLIER THIS

4815
03:00:36,320 --> 03:00:37,840
WEEK YOU CAN CONNECT WITH ME A

4816
03:00:37,840 --> 03:00:39,880
COUPLE OF TIMES.

4817
03:00:39,880 --> 03:00:43,720
SO I DESIGN/I TEND TO SPEAK MY

4818
03:00:43,720 --> 03:00:45,560
MIND SO I WILL HERE.

4819
03:00:45,560 --> 03:00:47,160
I'M NOT ENTHUSIASTIC ABOUT THIS,

4820
03:00:47,160 --> 03:00:49,280
TELL YOU WHY.

4821
03:00:49,280 --> 03:00:50,880
DOES BECAUSE OF MY PAST

4822
03:00:50,880 --> 03:00:52,320
EXPERIENCE HAVING TO DO THIS, I

4823
03:00:52,320 --> 03:00:54,480
WAS HEAD OF EDUCATION OF

4824
03:00:54,480 --> 03:00:56,080
NOVARTIS FOR SEVEN YEARS

4825
03:00:56,080 --> 03:00:56,800
MULTI-NATIONAL COMPANY WE

4826
03:00:56,800 --> 03:00:58,480
BASICALLY THE ORIGINAL IDEA WAS

4827
03:00:58,480 --> 03:01:01,320
DO IT ALL ONLINE, YOU HAVE SEX

4828
03:01:01,320 --> 03:01:03,360
CENTERS PUT IT ONLINE, WILL

4829
03:01:03,360 --> 03:01:05,160
LEARN DRUG DISCOVERY AND

4830
03:01:05,160 --> 03:01:06,720
EVERYTHING WILL BE HUNKY DORY,

4831
03:01:06,720 --> 03:01:08,920
ADULTS DON'T LEARN THAT WAY.

4832
03:01:08,920 --> 03:01:10,840
THIS IS -- THIS IS NOT THE MODEL

4833
03:01:10,840 --> 03:01:14,040
BY WHICH YOU ARE GOING TO GET

4834
03:01:14,040 --> 03:01:16,480
THE BIGGEST BANG FOR THE BUCK IN

4835
03:01:16,480 --> 03:01:17,440
MY OPINION.

4836
03:01:17,440 --> 03:01:18,880
THAT IS WHY THE COURSE IS SUCH

4837
03:01:18,880 --> 03:01:20,880
AS THE ONES YOU DEVELOPED

4838
03:01:20,880 --> 03:01:23,560
WHETHER THEY ARE ONLINE IN

4839
03:01:23,560 --> 03:01:24,840
CLASSROOM SESSIONS SPEAKING WITH

4840
03:01:24,840 --> 03:01:29,000
EXPERTS AND WHAT HAVE YOU REALLY

4841
03:01:29,000 --> 03:01:30,840
CASE STUDY METHODOLOGY AND OTHER

4842
03:01:30,840 --> 03:01:35,240
THINGS THAT MAKE A DIFFERENCE IS

4843
03:01:35,240 --> 03:01:36,560
PREFERRED TO JUST PUTTING THAT

4844
03:01:36,560 --> 03:01:37,880
OUT THERE BECAUSE IT IS TOO

4845
03:01:37,880 --> 03:01:38,280
PASSIVE.

4846
03:01:38,280 --> 03:01:40,480
THE OTHER CONCERN IS ONLINE

4847
03:01:40,480 --> 03:01:42,360
COURSE IF YOU PUT THIS RFA OUT

4848
03:01:42,360 --> 03:01:44,680
THERE OR WHATEVER APPROACH YOU

4849
03:01:44,680 --> 03:01:47,600
TAKE CALL FOR APPLICATION MY

4850
03:01:47,600 --> 03:01:49,680
CONCERN IS THE COMMUNITY WILL

4851
03:01:49,680 --> 03:01:52,160
JUST DEVELOP A WHOLE BUNCH OF

4852
03:01:52,160 --> 03:01:54,040
LECTURES, THEY WILL DO A SERIES,

4853
03:01:54,040 --> 03:01:56,120
FIND A BUNCH OF PEOPLE WHO GIVE

4854
03:01:56,120 --> 03:01:59,560
SERIES OF LECTURES ONE AFTER

4855
03:01:59,560 --> 03:02:00,960
ANOTHER, PART ONCOLOGIST

4856
03:02:00,960 --> 03:02:02,080
CLINICIAN TALK ABOUT SOMETHING

4857
03:02:02,080 --> 03:02:03,520
AND THEN THAT WILL GET POSTED AS

4858
03:02:03,520 --> 03:02:05,320
ONE AND THAT WILL GET POSTED AS

4859
03:02:05,320 --> 03:02:06,040
OTHER.

4860
03:02:06,040 --> 03:02:08,040
QUALITY CONTROL WILL VARY, THERE

4861
03:02:08,040 --> 03:02:09,600
WON'T BE ANY STRUCTURE

4862
03:02:09,600 --> 03:02:11,520
NORMALIZATION OF PRINCIPLES THAT

4863
03:02:11,520 --> 03:02:12,520
WILL BE TAUGHT IN THERE.

4864
03:02:12,520 --> 03:02:14,640
IT WILL BE A BOON TOGGLE, I'M

4865
03:02:14,640 --> 03:02:16,680
JUST REALLY PRESENTING YOU THE

4866
03:02:16,680 --> 03:02:18,560
OTHER CONCERN THAT I WOULD HAVE

4867
03:02:18,560 --> 03:02:20,720
IN PUTTING THIS OUT THERE.

4868
03:02:20,720 --> 03:02:23,360
YOU SHOULD THINK CAREFULLY ABOUT

4869
03:02:23,360 --> 03:02:25,280
THIS IS WHERE YOU WANT TO INVEST

4870
03:02:25,280 --> 03:02:27,400
YOUR RESOURCES IN THE

4871
03:02:27,400 --> 03:02:29,400
EDUCATIONAL REALM,S WITH THE

4872
03:02:29,400 --> 03:02:31,760
ONLINE ARENA.

4873
03:02:31,760 --> 03:02:37,720
I I'M NOT -- I WILL THROW

4874
03:02:37,720 --> 03:02:39,280
POSITIVES OUT THERE NOT JUST TO

4875
03:02:39,280 --> 03:02:40,080
BE NEGATIVE.

4876
03:02:40,080 --> 03:02:41,520
ONE THING THAT ACTUALLY WORK

4877
03:02:41,520 --> 03:02:44,240
WHICH TOOK A LOT TO DEVELOP, OUT

4878
03:02:44,240 --> 03:02:46,600
THERE AS FREE WARE, I KNOW A

4879
03:02:46,600 --> 03:02:48,360
BRAZILIAN GROUP, THEY CALL THEIR

4880
03:02:48,360 --> 03:02:50,040
GAME SCREENER, WE DEVELOP A GAME

4881
03:02:50,040 --> 03:02:52,680
IN PHARMA, IN THE NOVARTIS

4882
03:02:52,680 --> 03:02:54,040
CALLED PHARMA GAME OR SOMETHING

4883
03:02:54,040 --> 03:02:54,440
LIKE THAT.

4884
03:02:54,440 --> 03:02:56,000
FORGET HOW THEY BRANDED IT BUT

4885
03:02:56,000 --> 03:03:03,080
YOU CAN DEVELOP A GAME WHICH IS

4886
03:03:03,080 --> 03:03:04,680
WHETHER OUR TEENAGERS DO IS PLAY

4887
03:03:04,680 --> 03:03:06,280
A GAME ALL THE TIME, PLAY A GAME

4888
03:03:06,280 --> 03:03:07,920
AND LEARN DRUG DISCOVERY THAT

4889
03:03:07,920 --> 03:03:09,280
MIGHT HAVE MORE IMPACT AND MIGHT

4890
03:03:09,280 --> 03:03:18,640
BE A COOL WAY TO MEET APPROACH

4891
03:03:18,640 --> 03:03:19,800
OF CURRENT GENERATION DRUG

4892
03:03:19,800 --> 03:03:20,320
DISCOVERY.

4893
03:03:20,320 --> 03:03:21,480
IF YOU CAN INCLUDE IT MIGHT BE

4894
03:03:21,480 --> 03:03:23,880
INTERESTING TO SEE IF

4895
03:03:23,880 --> 03:03:26,800
PROGRAMMERS OUT THERE CAN THINK

4896
03:03:26,800 --> 03:03:30,400
ABOUT THE COMPLEXITY OF THE

4897
03:03:30,400 --> 03:03:32,720
WIRING DIAGRAM IN LAST SLIDE

4898
03:03:32,720 --> 03:03:34,000
MEANT TO HAPPEN FASTER AND TAKE

4899
03:03:34,000 --> 03:03:36,640
THAT WIRING DIAGRAM AND FIGURE A

4900
03:03:36,640 --> 03:03:40,280
WAY TO DO INPUT OUTPUT CIRCUIT

4901
03:03:40,280 --> 03:03:41,400
GAIN YOU CAN THEN AS GROUP

4902
03:03:41,400 --> 03:03:44,120
DECISION MAKING MAY TRICK.

4903
03:03:44,120 --> 03:03:46,080
SO -- MATRIX.

4904
03:03:46,080 --> 03:03:47,200
SO PK IS NOT GOOD.

4905
03:03:47,200 --> 03:03:48,840
WHAT THE HELL DO YOU DO NEXT?

4906
03:03:48,840 --> 03:03:50,280
THAT'S WHAT IT COSTS ANOTHER

4907
03:03:50,280 --> 03:03:50,680
MILLION DOLLARS.

4908
03:03:50,680 --> 03:03:52,480
DO YOU HAVE THE MONEY, YOU DON'T

4909
03:03:52,480 --> 03:03:54,440
HAVE THE MONEY SO HOW DO YOU

4910
03:03:54,440 --> 03:03:55,480
KNOW HUH WHOM TO EMPERIMENT.

4911
03:03:55,480 --> 03:03:57,480
YOU COLLECT -- YOU DO A

4912
03:03:57,480 --> 03:03:59,320
DIFFERENT EXPERIMENT TAKE HELO

4913
03:03:59,320 --> 03:04:00,440
CELLS AND THAT DOESN'T WORK.

4914
03:04:00,440 --> 03:04:01,680
WHAT IS NEXT EXPERIMENT?

4915
03:04:01,680 --> 03:04:03,080
THAT MIGHT TEACH THEM MORE THAN

4916
03:04:03,080 --> 03:04:04,440
A BUNCH OF DRY LECTURES THAT

4917
03:04:04,440 --> 03:04:06,240
ESSENTIAL WILL I PUTTING TO ON A

4918
03:04:06,240 --> 03:04:07,360
WEBSITE.

4919
03:04:07,360 --> 03:04:11,200
SO THAT WOULD BE I WILL STOP

4920
03:04:11,200 --> 03:04:11,400
WILL.

4921
03:04:11,400 --> 03:04:12,560
TRILLION READING WHAT YOU SAY,

4922
03:04:12,560 --> 03:04:14,240
I'M NOT SURE WHETHER THE

4923
03:04:14,240 --> 03:04:15,680
COMMUNITY THAT IS GOING TO

4924
03:04:15,680 --> 03:04:17,200
RESPOND TO THIS I HATE TO SAY

4925
03:04:17,200 --> 03:04:20,120
WILL BE OUR GENERATION.

4926
03:04:20,120 --> 03:04:23,760
OURS IS GOING TO (INAUDIBLE)

4927
03:04:23,760 --> 03:04:25,200
SOMETHING NOT GOING TO WORK FOR

4928
03:04:25,200 --> 03:04:26,080
THE NEXT GENERATION IN ONLINE

4929
03:04:26,080 --> 03:04:30,160
SPACE.

4930
03:04:30,160 --> 03:04:31,040
>> THANK YOU.

4931
03:04:31,040 --> 03:04:31,840
ANYTHING TO RESPOND?

4932
03:04:31,840 --> 03:04:33,200
WE WILL OPEN IT UP.

4933
03:04:33,200 --> 03:04:36,880
>> I APPRECIATE THE COMMENTS AND

4934
03:04:36,880 --> 03:04:40,960
I THINK THERE ARE MANY CAVEATS

4935
03:04:40,960 --> 03:04:44,040
HERE AND THINGS TO THINK ABOUT.

4936
03:04:44,040 --> 03:04:46,560
ONE OF THE THINGS SO HERE ARE

4937
03:04:46,560 --> 03:04:48,080
SOME OF THE CHALLENGES THAT I

4938
03:04:48,080 --> 03:04:48,480
SEE.

4939
03:04:48,480 --> 03:04:50,560
ONE OF THE REASONS WE DID THE --

4940
03:04:50,560 --> 03:04:53,080
WE START WITH THE ONLINE COURSE

4941
03:04:53,080 --> 03:04:54,920
WHICH AGAIN MAY -- IS VERY

4942
03:04:54,920 --> 03:05:02,360
TRADITIONAL, I HOPE WE CAN DO

4943
03:05:02,360 --> 03:05:03,880
THIS IN A LOT OF WAYS.

4944
03:05:03,880 --> 03:05:07,000
WAS TO REACH MORE PEOPLE MORE

4945
03:05:07,000 --> 03:05:09,040
UNDERGRADS AND THINK ABOUT THOSE

4946
03:05:09,040 --> 03:05:11,600
SEGMENTS THAT AREN'T HEARING

4947
03:05:11,600 --> 03:05:15,280
TRANSLATIONAL SIEBS OR MIGHT NOT

4948
03:05:15,280 --> 03:05:16,880
BE AT A HUB IN A FORMAL TRAINING

4949
03:05:16,880 --> 03:05:18,160
PROGRAM.

4950
03:05:18,160 --> 03:05:22,680
SO REALLY THINKING HOW DO WE

4951
03:05:22,680 --> 03:05:23,800
PUSH TRANSLATIONAL SCIENCE

4952
03:05:23,800 --> 03:05:24,880
EDUCATION OUT WILL TO MORE

4953
03:05:24,880 --> 03:05:29,840
PEOPLE AND EXPAND THE WORK FORCE

4954
03:05:29,840 --> 03:05:31,560
AND DI VERY PHI WHO WE RECRUIT

4955
03:05:31,560 --> 03:05:32,280
TO THE WORK FORCE.

4956
03:05:32,280 --> 03:05:35,480
THAT IS ONE PRINCIPLE UNDERLYING

4957
03:05:35,480 --> 03:05:35,920
THIS.

4958
03:05:35,920 --> 03:05:37,840
IS GETTING TRANSLATIONAL SCIENCE

4959
03:05:37,840 --> 03:05:42,400
EDUCATION TO MORE PEOPLE.

4960
03:05:42,400 --> 03:05:43,480
I UNDERSTAND SOME OF THE

4961
03:05:43,480 --> 03:05:45,840
CONCERNS YOU MAZE RAISE, WITHIN

4962
03:05:45,840 --> 03:05:50,200
NIH WE HAVE DIFFERENT WAYS WE

4963
03:05:50,200 --> 03:05:52,160
CAN DI SIGN FUND MECHANISMS

4964
03:05:52,160 --> 03:05:54,360
WHERE THERE'S GREATER

4965
03:05:54,360 --> 03:05:56,560
INVOLVEMENT FROM M CATS STAFF

4966
03:05:56,560 --> 03:06:00,840
AND WE CAN HELP SHAPE THINGS

4967
03:06:00,840 --> 03:06:02,880
LITTLE MORE AS DR. JACKSON SAID

4968
03:06:02,880 --> 03:06:05,760
THROUGH CONSORTIUM PROCESS AND

4969
03:06:05,760 --> 03:06:09,000
SETTING CENTRALIZED EVALUATION

4970
03:06:09,000 --> 03:06:14,920
MATRIX -- MEASURES AND BEING

4971
03:06:14,920 --> 03:06:18,000
ABLE TO HAVE THAT SORT OF I

4972
03:06:18,000 --> 03:06:19,600
DON'T KNOW IF I WANT TO USE

4973
03:06:19,600 --> 03:06:20,800
OVERSIGHT BUT MORE CENTRALIZED

4974
03:06:20,800 --> 03:06:22,560
FUNCTION ACROSS ALL THESE

4975
03:06:22,560 --> 03:06:23,400
ACTIVITIES.

4976
03:06:23,400 --> 03:06:25,920
WE COULD HELP SHAPE THAT AS

4977
03:06:25,920 --> 03:06:26,800
WELL.

4978
03:06:26,800 --> 03:06:29,080
SO I UNDERSTAND WHAT YOU ARE

4979
03:06:29,080 --> 03:06:29,280
SAYING.

4980
03:06:29,280 --> 03:06:31,360
(OVERLAPPING SPEAKERS)

4981
03:06:31,360 --> 03:06:34,440
>> THIS MAY NOT FIT INTO YOUR

4982
03:06:34,440 --> 03:06:36,360
SCHEME OF THINGS.

4983
03:06:36,360 --> 03:06:38,480
SEND THIS OUT AS THINGS FOR HIGH

4984
03:06:38,480 --> 03:06:39,720
SCHOOL STUDENTS AND COLLEGE

4985
03:06:39,720 --> 03:06:44,560
STUDENTS TO BUILD RATHER THAN

4986
03:06:44,560 --> 03:06:46,160
YOUR PI IN SOME UNIVERSITY AND

4987
03:06:46,160 --> 03:06:49,920
THEN GIVE HEM THE EXPERTISE THEY

4988
03:06:49,920 --> 03:06:51,920
NEED TO LEARN BUT THEY CAN BUILD

4989
03:06:51,920 --> 03:06:53,520
WHAT NEEDS TO BE BUILT TO HELP

4990
03:06:53,520 --> 03:06:56,360
PEERS LEARN.

4991
03:06:56,360 --> 03:06:58,680
I THINK WHAT WE NEED IN THIS

4992
03:06:58,680 --> 03:07:00,560
SITUATION IS SOME THOUGHTFUL

4993
03:07:00,560 --> 03:07:02,320
EXPERTISE IN EDUCATIONAL

4994
03:07:02,320 --> 03:07:03,680
METHODOLOGY THAT WORKS FOR THE

4995
03:07:03,680 --> 03:07:04,680
GENERATION THAT WE ARE TRYING TO

4996
03:07:04,680 --> 03:07:11,400
TEACH.

4997
03:07:11,400 --> 03:07:14,520
NOT THE SAME YOU AND I LEARNED.

4998
03:07:14,520 --> 03:07:16,240
WE MAKE THIS MISTAKE ALL THE

4999
03:07:16,240 --> 03:07:18,440
TIME, IF WE TAKE IT THE WAY WE

5000
03:07:18,440 --> 03:07:20,040
LEARN IT THEY WILL LEARN IT.

5001
03:07:20,040 --> 03:07:21,320
I DON'T THINK THAT WORKS.

5002
03:07:21,320 --> 03:07:22,200
>> GOOD POINT.

5003
03:07:22,200 --> 03:07:23,840
GO I A HEAD.

5004
03:07:23,840 --> 03:07:27,120
>> IT IS CLEARLY A SIGNIFICANT

5005
03:07:27,120 --> 03:07:29,840
UNMET NEED THERE IS A FAIR

5006
03:07:29,840 --> 03:07:31,400
ENOUGH ACTIVITY IN THE SPACE

5007
03:07:31,400 --> 03:07:38,800
WHICH IF YOU CAN REACH INTO

5008
03:07:38,800 --> 03:07:40,360
CONCEPT OF ONTOLOGY, FRAMEWORK

5009
03:07:40,360 --> 03:07:42,920
WHAT HAS BEEN DEVELOPED

5010
03:07:42,920 --> 03:07:46,040
INCLUDING IN OUR FORM OF

5011
03:07:46,040 --> 03:07:47,800
TRAINING CERTIFICATE WHERE

5012
03:07:47,800 --> 03:07:49,480
TRANSLATIONAL ELEMENTS ARE

5013
03:07:49,480 --> 03:07:50,520
TAUGHT, THEIR DISEASE SPACE BUT

5014
03:07:50,520 --> 03:07:53,200
MIGHT BE GENERALLY APPLICABLE IN

5015
03:07:53,200 --> 03:07:59,120
SEVERAL CTSA SITES, TRANSLATION

5016
03:07:59,120 --> 03:08:01,200
TRAINING PROGRAMS ONLINE SO THEN

5017
03:08:01,200 --> 03:08:02,720
I THINK WOULD BE DELIVERABLE

5018
03:08:02,720 --> 03:08:06,280
WHICH WOULD HAVE IMMEDIATE

5019
03:08:06,280 --> 03:08:09,640
IMPACT EXTENDING ON RAJESH

5020
03:08:09,640 --> 03:08:13,920
CONCEPT, WE ARE DEVELOPING

5021
03:08:13,920 --> 03:08:15,360
COMPETITION FOR SPECIFIC NEEDS

5022
03:08:15,360 --> 03:08:21,080
TO SOFTWARE DEVELOPMENT FOR

5023
03:08:21,080 --> 03:08:22,120
MOLECULAR BIOLOGY DATA MINING

5024
03:08:22,120 --> 03:08:26,760
TOOLS.

5025
03:08:26,760 --> 03:08:30,440
THIS COULD BE ADOPTED AS WELL

5026
03:08:30,440 --> 03:08:32,800
DEFINE EDUCATIONAL PROBLEM AND

5027
03:08:32,800 --> 03:08:34,240
YOU LET COMPETITION COMPETE

5028
03:08:34,240 --> 03:08:36,680
LARGE COMMUNITY OF DIVERSE

5029
03:08:36,680 --> 03:08:38,480
STAKEHOLDERS AND THEN YOU HAVE A

5030
03:08:38,480 --> 03:08:40,320
BENCHMARKING PROCESS AND THAT IS

5031
03:08:40,320 --> 03:08:43,120
A KEY PIECE TO DEVELOP

5032
03:08:43,120 --> 03:08:46,280
INNOVATIVE CREATIVE EFFECTIVE

5033
03:08:46,280 --> 03:08:49,160
BENCHMARK,OBVIOUSLY THE COUNTER

5034
03:08:49,160 --> 03:08:50,080
COMPETITIONS BUT MIGHT BE A WAY

5035
03:08:50,080 --> 03:08:51,880
TO PULL IN UNEXPECTED IN A WAY

5036
03:08:51,880 --> 03:08:55,960
THAT YOU ARE NOT CONSTRAINING TO

5037
03:08:55,960 --> 03:08:59,280
ONLY ONE OR TWO BUT YOU GET WIDE

5038
03:08:59,280 --> 03:09:01,280
SPECTRUM OF SOLUTIONS, YOU CAN

5039
03:09:01,280 --> 03:09:04,480
SET UP COMPETITION THAT YOU HAVE

5040
03:09:04,480 --> 03:09:06,120
STAGGERED RESOURCE DISTRIBUTION

5041
03:09:06,120 --> 03:09:13,080
TO MAIN PERFORMANCE.

5042
03:09:13,080 --> 03:09:14,440
WHICH IS OUT AND COULD BE

5043
03:09:14,440 --> 03:09:14,840
ENGAGED.

5044
03:09:14,840 --> 03:09:17,480
VERY YOUNG COMPETITORS ENTERING

5045
03:09:17,480 --> 03:09:19,200
THESE SPACE AND SOMETIMES THEY

5046
03:09:19,200 --> 03:09:25,520
ARE NOT TRAINING LEADING EDGE.

5047
03:09:25,520 --> 03:09:31,120
>> YOU MADE COMMENTS IN CHAT.

5048
03:09:31,120 --> 03:09:36,480
SAY ANYTHING MOTHER?

5049
03:09:36,480 --> 03:09:39,440
>> I THINK WHAT YOU DESCRIBE THE

5050
03:09:39,440 --> 03:09:42,080
GOAL OF PROFESSIONALIZING

5051
03:09:42,080 --> 03:09:43,680
TRANSLATIONAL SCIENCE AS A

5052
03:09:43,680 --> 03:09:46,400
DOMAIN OF EXPERTISE IS

5053
03:09:46,400 --> 03:09:47,000
NECESSARY.

5054
03:09:47,000 --> 03:09:49,200
IF IF GOAL IS TO REACH YOUNGER

5055
03:09:49,200 --> 03:09:53,440
GENERATION I AGREE WITH RAGESH

5056
03:09:53,440 --> 03:09:55,200
DO AN EXPERIMENT ON THE SIDE AND

5057
03:09:55,200 --> 03:09:57,960
GUILTY IT BUT IF YOU ARE GOING

5058
03:09:57,960 --> 03:10:01,080
TO GAMEFY IT DON'T DO IT IN A

5059
03:10:01,080 --> 03:10:02,280
WEB 2.0, GO ALL THE WAY.

5060
03:10:02,280 --> 03:10:05,680
GO ALL IN AND DO IT IN A WEB 3.0

5061
03:10:05,680 --> 03:10:06,240
ENVIRONMENT THEN REACH THE

5062
03:10:06,240 --> 03:10:13,760
WORLD.

5063
03:10:13,760 --> 03:10:15,760
>> MAKE IT VR.

5064
03:10:15,760 --> 03:10:17,280
>> AGAIN, I DON'T WANT TO TAKE

5065
03:10:17,280 --> 03:10:19,280
UP ALL THE REST OF THE TIME, IT

5066
03:10:19,280 --> 03:10:20,680
IS LIKE I WAS JUST TEXTING

5067
03:10:20,680 --> 03:10:22,160
BECAUSE I WAS GETTING REALLY

5068
03:10:22,160 --> 03:10:23,640
INTO IT BECAUSE I'M INTO THIS

5069
03:10:23,640 --> 03:10:26,080
SORT OF THING AND WE BUILD THIS

5070
03:10:26,080 --> 03:10:26,640
STUFF.

5071
03:10:26,640 --> 03:10:30,080
SO IT JUST HIT A NERVE IF THE

5072
03:10:30,080 --> 03:10:32,640
GOAL IS THE YOUNGER GENERATION,

5073
03:10:32,640 --> 03:10:37,360
I THINK IT IS WORTH THINKING

5074
03:10:37,360 --> 03:10:39,400
CONTENT DELIVERY IN NEW WAY BUT

5075
03:10:39,400 --> 03:10:41,080
YOU HAVE BEEN SO THOUGHTFUL WHAT

5076
03:10:41,080 --> 03:10:46,120
THAT CONTENT IS.

5077
03:10:46,120 --> 03:10:48,360
IT WAS JUST WRAPPING.

5078
03:10:48,360 --> 03:10:51,720
>> I WOULD SECOND KELLY, I THINK

5079
03:10:51,720 --> 03:10:53,320
THE CONTENT IS NOT THE ISSUE.

5080
03:10:53,320 --> 03:10:55,480
IT WAS REALLY ABOUT HOW YOU WANT

5081
03:10:55,480 --> 03:10:56,760
TO GET THIS ACROSS.

5082
03:10:56,760 --> 03:10:58,440
WHO YOUR AUDIENCE IS.

5083
03:10:58,440 --> 03:11:00,240
IF YOUR AUDIENCE IS 30

5084
03:11:00,240 --> 03:11:01,560
SOMETHINGs AND BELOW WHO YOU

5085
03:11:01,560 --> 03:11:04,920
ARE WANTING TO BE THE NEXT

5086
03:11:04,920 --> 03:11:05,440
GENERATION HAVE GROWN UP

5087
03:11:05,440 --> 03:11:06,720
DIFFERENTLY THAN WE HAVE.

5088
03:11:06,720 --> 03:11:09,280
>> RIGHT.

5089
03:11:09,280 --> 03:11:11,000
YOU DID COME ACROSS AS SOUNDING

5090
03:11:11,000 --> 03:11:12,280
LIKE A LITTLE BIT LIKE YOU WERE

5091
03:11:12,280 --> 03:11:13,240
CRITICIZING THE CONTEMPT.

5092
03:11:13,240 --> 03:11:16,160
JUST MY OPINION.

5093
03:11:16,160 --> 03:11:18,960
IT IS GOOD YOU CLARIFIED THAT

5094
03:11:18,960 --> 03:11:19,560
YOU DIDN'T MEAN THAT.

5095
03:11:19,560 --> 03:11:20,320
>> GOOD.

5096
03:11:20,320 --> 03:11:21,920
THANK YOU.

5097
03:11:21,920 --> 03:11:23,760
KEITH I SEE YOUR HAND THEN WE

5098
03:11:23,760 --> 03:11:25,080
WILL LET BECK KY HAVE THE LAST

5099
03:11:25,080 --> 03:11:29,200
WORD HERE.

5100
03:11:29,200 --> 03:11:34,480
KEITH GO AHEAD.

5101
03:11:34,480 --> 03:11:37,320
>> I THINK YOU ARE MUTED.

5102
03:11:37,320 --> 03:11:38,280
>> YOU ARE ON MUTE STILL.

5103
03:11:38,280 --> 03:11:44,280
>> THANK YOU.

5104
03:11:44,280 --> 03:11:45,680
I'M INTRIGUED BY THE VALUATION

5105
03:11:45,680 --> 03:11:46,600
COMPONENT AND ESPECIALLY

5106
03:11:46,600 --> 03:11:49,480
INTERESTED IN BEING SURE WE WILL

5107
03:11:49,480 --> 03:11:54,520
LEARN HOW TO REACH DIFFERENT

5108
03:11:54,520 --> 03:11:56,480
AUDIENCES DIFFERENTLY, I DON'T

5109
03:11:56,480 --> 03:11:57,600
MEAN THE YOUTH AUDIENT.

5110
03:11:57,600 --> 03:11:59,160
THAT IS MADE ALREADY.

5111
03:11:59,160 --> 03:12:00,720
I'M THINKING IN TERMS OF

5112
03:12:00,720 --> 03:12:03,440
DIVERSITY, IT IS A CHALLENGE FOR

5113
03:12:03,440 --> 03:12:06,320
ME AS AN STROBING TORR EVEN IN A

5114
03:12:06,320 --> 03:12:07,320
LIVE ENVIRONMENT TO THINK HOW

5115
03:12:07,320 --> 03:12:09,400
DID I SAY THAT AND DID I SAY IN

5116
03:12:09,400 --> 03:12:14,400
A WAY THAT RESONATES WITH

5117
03:12:14,400 --> 03:12:15,960
DIVERSE AUDIENCE BY RACE

5118
03:12:15,960 --> 03:12:16,880
ETHNICITY AGE, ET CETERA.

5119
03:12:16,880 --> 03:12:19,760
RATHER THAN JUST GETTING BACK

5120
03:12:19,760 --> 03:12:23,680
COUNTS OF WHO AND WHAT TYPES OF

5121
03:12:23,680 --> 03:12:27,000
PEOPLE WENT THROUGH WHETHER

5122
03:12:27,000 --> 03:12:28,280
GETTING BACK GENERAL IMPRESSIONS

5123
03:12:28,280 --> 03:12:31,800
I WOULD LOVE TO SEE INNOVATION.

5124
03:12:31,800 --> 03:12:35,320
HOW DO WE LEARN HOW TO TAILOR

5125
03:12:35,320 --> 03:12:36,800
OUR PEDAGOGUE NO MATTER WHAT IT

5126
03:12:36,800 --> 03:12:38,640
IS TOWARD THE DIFFERENT

5127
03:12:38,640 --> 03:12:39,280
AUDIENCES.

5128
03:12:39,280 --> 03:12:42,520
AND FINALLY VERY USE -- THEIR

5129
03:12:42,520 --> 03:12:44,720
USE OF THAT IN THEIR

5130
03:12:44,720 --> 03:12:49,480
TRANSLATIONAL WORK AS THEY REACH

5131
03:12:49,480 --> 03:12:57,120
OUT, TO A MORE DIVERSE AUDIENCE.

5132
03:12:57,120 --> 03:12:58,040
>> WELL TAKEN.

5133
03:12:58,040 --> 03:12:59,080
THANK YOU.

5134
03:12:59,080 --> 03:12:59,520
BECKY.

5135
03:12:59,520 --> 03:13:01,160
>> IT SOUNDS LIKE THERE IS A

5136
03:13:01,160 --> 03:13:06,160
CONSENSUS AMONG ALL OF US THAT

5137
03:13:06,160 --> 03:13:07,600
TRADITIONAL LECTURE WITH

5138
03:13:07,600 --> 03:13:09,760
POWERPOINT SLIDES, PROBABLY AN

5139
03:13:09,760 --> 03:13:13,120
INEFFECTIVE STRATEGY FOR

5140
03:13:13,120 --> 03:13:13,960
CERTAINLY CAN BE BACKGROUND

5141
03:13:13,960 --> 03:13:15,080
MATERIAL BUT IT CLEARLY ISN'T

5142
03:13:15,080 --> 03:13:18,960
THE MOST EFFECTIVE WAY I THINK

5143
03:13:18,960 --> 03:13:20,760
IF YOU REALLY EXPAND THIS TO

5144
03:13:20,760 --> 03:13:26,520
THINK OF HOW CAN WE USE OTHER

5145
03:13:26,520 --> 03:13:30,240
ONLINE THAT INCLUDES LOTS OF

5146
03:13:30,240 --> 03:13:31,400
DIFFERENT APPROACH AND THINK HOW

5147
03:13:31,400 --> 03:13:35,320
THAT ACTUALLY BRINGS ACROSS

5148
03:13:35,320 --> 03:13:35,920
PROCESS GUILTYCATION SOMETHING

5149
03:13:35,920 --> 03:13:38,320
WE USE A LOT OF.

5150
03:13:38,320 --> 03:13:42,240
SOUNDS LIKE YOU DO TOO.

5151
03:13:42,240 --> 03:13:43,960
IT IS SIMPLY MORE ENGAGING BUT

5152
03:13:43,960 --> 03:13:46,320
BRINGING TOGETHER IN A WAY THAT

5153
03:13:46,320 --> 03:13:47,720
YOU HAVE MORE INTEGRATED SYSTEM

5154
03:13:47,720 --> 03:13:50,720
AND THEN THE WAY TO BE ABLE TO

5155
03:13:50,720 --> 03:13:52,080
SEARCH WHAT YOU NEED AT THE TIME

5156
03:13:52,080 --> 03:13:57,080
YOU NEED IT.

5157
03:13:57,080 --> 03:13:59,640
WOULD ADVANCE ALONG AS YOU MAKE

5158
03:13:59,640 --> 03:14:03,880
IT AN AVAILABLE SOURCE.

5159
03:14:03,880 --> 03:14:06,480
>> THANK YOU FOR THAT.

5160
03:14:06,480 --> 03:14:08,160
ANY FINAL THOUGHTS HERE TO

5161
03:14:08,160 --> 03:14:12,280
RELAY?

5162
03:14:12,280 --> 03:14:14,080
>> THIS IS HELPFUL I'M EXCITED

5163
03:14:14,080 --> 03:14:16,120
TO HEAR THE THEWS AM AROUND THE

5164
03:14:16,120 --> 03:14:19,080
CONTENT PIECE AND SOUNDS LIKE

5165
03:14:19,080 --> 03:14:26,040
THE OTHER SUGGESTIONS GO FURTHER

5166
03:14:26,040 --> 03:14:28,000
AS FAR AS FOSTERING MORE

5167
03:14:28,000 --> 03:14:33,320
CREATIVE APPROACH HERE.

5168
03:14:33,320 --> 03:14:36,240
THAT WOULD BE EXCITING FORWARD

5169
03:14:36,240 --> 03:14:37,240
THING FOR NCATS TO DO LIKE

5170
03:14:37,240 --> 03:14:40,960
ALWAYS.

5171
03:14:40,960 --> 03:14:42,080
>> THANK YOU SO MUCH.

5172
03:14:42,080 --> 03:14:43,760
WE HAVE A LOT TO THINK ABOUT.

5173
03:14:43,760 --> 03:14:48,880
WBEWILL MOVE TO THE NEXT CONCEPT

5174
03:14:48,880 --> 03:14:49,560
CLEARANCE, PRESENTATION.

5175
03:14:49,560 --> 03:14:58,440
>> WE NEED TO VOTE.

5176
03:14:58,440 --> 03:15:00,920
>> NO FURTHER DISCUSSION.

5177
03:15:00,920 --> 03:15:02,720
MOTION TO ADVANCE CONCEPT WITH

5178
03:15:02,720 --> 03:15:05,800
THEIR COMMENTS UNDER ADVISE.

5179
03:15:05,800 --> 03:15:07,440
>> SO MOVED.

5180
03:15:07,440 --> 03:15:08,040
>> SECOND?

5181
03:15:08,040 --> 03:15:09,520
>> SECOND.

5182
03:15:09,520 --> 03:15:11,960
>> ALL IN FAVOR

5183
03:15:11,960 --> 03:15:12,720
>> AYE.

5184
03:15:12,720 --> 03:15:14,840
AYE.

5185
03:15:14,840 --> 03:15:15,600
AYE.

5186
03:15:15,600 --> 03:15:21,520
>> ANY ABSTENTIONS?

5187
03:15:21,520 --> 03:15:27,840
NEXT CONCEPT PLEASE.

5188
03:15:27,840 --> 03:15:29,080
>> I WANT THE MAKE SURE YOU GOT

5189
03:15:29,080 --> 03:15:30,000
THE ONE EXTENSION THERE.

5190
03:15:30,000 --> 03:15:32,840
DID YOU GET IT, ANNA?

5191
03:15:32,840 --> 03:15:34,280
>> I ABSTAINED BUT I WAS ON

5192
03:15:34,280 --> 03:15:37,080
MUTE.

5193
03:15:37,080 --> 03:15:37,920
>> GOT IT.

5194
03:15:37,920 --> 03:15:39,720
WANT TO MAKE SURE.

5195
03:15:39,720 --> 03:15:42,600
>> WE WILL GO AHEAD AND MOVE TO

5196
03:15:42,600 --> 03:15:43,960
THE NEXT CONCEPT CLEARANCE.

5197
03:15:43,960 --> 03:15:45,440
THIS IS WITH OFFICE OF SPECIAL

5198
03:15:45,440 --> 03:15:45,920
INITIATIVES.

5199
03:15:45,920 --> 03:15:48,440
I WILL TURN IT OVER TO DAN

5200
03:15:48,440 --> 03:15:48,880
TAGLE.

5201
03:15:48,880 --> 03:15:52,840
PLEASE TAKE IT AWAY.

5202
03:15:52,840 --> 03:15:54,000
>> THANK YOU, GOOD AFTERNOON

5203
03:15:54,000 --> 03:15:55,040
EVERYONE, THANK YOU FOR HANGING

5204
03:15:55,040 --> 03:15:56,080
IN FOR THE LAST PRESENTATION OF

5205
03:15:56,080 --> 03:15:56,800
THE DAY.

5206
03:15:56,800 --> 03:15:58,880
I'M DAN TAGLE, DIRECTOR OF

5207
03:15:58,880 --> 03:16:00,120
OFFICE OF SPECIAL INITIATIVES

5208
03:16:00,120 --> 03:16:02,040
HERE TO GIVE A BACKGROUND ABOUT

5209
03:16:02,040 --> 03:16:03,840
THE OFFICE AS WELL AS SOME

5210
03:16:03,840 --> 03:16:05,880
BACKGROUND ABOUT THE INITIATIVE.

5211
03:16:05,880 --> 03:16:10,640
NEXT SLIDE PLEASE.

5212
03:16:10,640 --> 03:16:13,080
BRIEFLY AGAIN, I MENTIONED IN

5213
03:16:13,080 --> 03:16:14,000
CLOSE SESSION THE MISSION OF

5214
03:16:14,000 --> 03:16:16,880
OFFICE OF SPECIAL INITIATIVES IS

5215
03:16:16,880 --> 03:16:19,120
REALLY TO DEVELOP INNOVATIVE

5216
03:16:19,120 --> 03:16:20,680
SOLUTIONS THROUGH DISRUPTIVE

5217
03:16:20,680 --> 03:16:21,880
TECHNOLOGY AND OTHER

5218
03:16:21,880 --> 03:16:22,480
PARTNERSHIPS IN ORDER THE

5219
03:16:22,480 --> 03:16:27,120
ADDRESS THE MAJOR TRANSLATIONAL

5220
03:16:27,120 --> 03:16:28,920
PROBLEMS THAT THAT PERVADE IN

5221
03:16:28,920 --> 03:16:29,240
THE FIELD.

5222
03:16:29,240 --> 03:16:33,960
SO THIS IS A LISTING OF PROGRAMS

5223
03:16:33,960 --> 03:16:35,680
AND ACTIVITIES WITHIN OFFICE OF

5224
03:16:35,680 --> 03:16:37,080
SPECIAL INITIATIVES.

5225
03:16:37,080 --> 03:16:39,960
SO THE CONCEPT THAT IS UP FOR

5226
03:16:39,960 --> 03:16:44,280
YOUR DISCUSSION AND CONCURRENCE

5227
03:16:44,280 --> 03:16:47,400
IS THE -- SO THAT EXTREME STANDS

5228
03:16:47,400 --> 03:16:49,680
FOR EXOSOME BASED THERAPIES FOR

5229
03:16:49,680 --> 03:16:52,000
REGENERATIVE MEDICINE, THIS WILL

5230
03:16:52,000 --> 03:16:58,120
BE A NEW INITIATIVE WITHIN THE

5231
03:16:58,120 --> 03:17:00,120
OFFICE BUT I WANT TO MEMBERS OF

5232
03:17:00,120 --> 03:17:01,280
THEY JURY IT LEVERAGES PREVIOUS

5233
03:17:01,280 --> 03:17:02,160
INVESTMENTS FROM THE NIH COMMON

5234
03:17:02,160 --> 03:17:06,160
FUND.

5235
03:17:06,160 --> 03:17:07,880
EXTRA CELLULAR RNA COMMUNICATION

5236
03:17:07,880 --> 03:17:10,960
INDICATED IN ONE BULLET ABOVE

5237
03:17:10,960 --> 03:17:13,200
WHICH LOOKS AT SECRETED RNA

5238
03:17:13,200 --> 03:17:15,080
PRIMARILY FOR BIOMARKER THERAPY

5239
03:17:15,080 --> 03:17:17,560
DEVELOPMENT.

5240
03:17:17,560 --> 03:17:20,480
SO THERE IS FROM COMMON FUND IN

5241
03:17:20,480 --> 03:17:22,440
TERMS OF TOOLS AND RESOURCES

5242
03:17:22,440 --> 03:17:23,640
DEVELOPED IN ORDER TO ISOLATE

5243
03:17:23,640 --> 03:17:24,400
EXOSOMES.

5244
03:17:24,400 --> 03:17:28,200
SO NEXT SLIDE.

5245
03:17:28,200 --> 03:17:32,440
WHAT ARE EXSOME?

5246
03:17:32,440 --> 03:17:34,640
THEY HAVE BEEN RECOGNIZED AS AN

5247
03:17:34,640 --> 03:17:37,280
ARTIFACT OR PERHAPS CELL DEBRIS,

5248
03:17:37,280 --> 03:17:38,520
IT HAS ONLY BEEN RECOGNIZED

5249
03:17:38,520 --> 03:17:40,080
WITHIN THE LAST DECADE OR SO

5250
03:17:40,080 --> 03:17:45,160
THAT IT ACTUALLY CARRIES FORTH

5251
03:17:45,160 --> 03:17:46,120
AN IMPORTANT FUNCTION WITHIN THE

5252
03:17:46,120 --> 03:17:49,480
BODY.

5253
03:17:49,480 --> 03:17:52,160
THAT FUNCTION IS NOVEL MESSENGER

5254
03:17:52,160 --> 03:17:54,680
FOR INTERCELLULAR COMMUNICATION.

5255
03:17:54,680 --> 03:17:56,080
EXOSOMES ARE ESSENTIALLY

5256
03:17:56,080 --> 03:17:59,000
DIFFERENT SHADED FROM OTHER

5257
03:17:59,000 --> 03:18:01,960
MICROVESICAL MS. THE SENSE

5258
03:18:01,960 --> 03:18:03,960
MICROVESICALS FROM PLASMA

5259
03:18:03,960 --> 03:18:05,440
MEMBRANE WHEREAS ENDOSOMES ARE

5260
03:18:05,440 --> 03:18:09,280
RELEASED TO THE EXTRA CELLULAR

5261
03:18:09,280 --> 03:18:11,200
MATRIX WHEN VESICULAR BODIES

5262
03:18:11,200 --> 03:18:13,880
FUSE WITH CELL MEMBRANE SO

5263
03:18:13,880 --> 03:18:14,600
ENDOSOMAL ORIGIN.

5264
03:18:14,600 --> 03:18:16,800
THEY ARE PRETTY SMALL ORGANELLES

5265
03:18:16,800 --> 03:18:21,080
THEY ARE ABOUT 40 TO 150

5266
03:18:21,080 --> 03:18:22,080
NANOMETERS.

5267
03:18:22,080 --> 03:18:24,000
AND CARRY IMPORTANT BIOACTIVE

5268
03:18:24,000 --> 03:18:24,800
MOLECULES WHICH ARE IMPORTANT

5269
03:18:24,800 --> 03:18:27,400
FOR SIGNALING AS WELL AS FOR

5270
03:18:27,400 --> 03:18:28,880
OTHER CELLULAR FUNCTION.

5271
03:18:28,880 --> 03:18:32,080
SO THIS BIOACTIVE CARGO INCLUDES

5272
03:18:32,080 --> 03:18:34,440
LIPIDS PROTEINS, MESSENGER RNA

5273
03:18:34,440 --> 03:18:36,320
AND IMPORTANTLY ALSO REGULATORY

5274
03:18:36,320 --> 03:18:39,760
RNA SUCH AS MICRORNA AND LONG

5275
03:18:39,760 --> 03:18:40,480
NON-CODING RNAs.

5276
03:18:40,480 --> 03:18:46,080
THESE EXSOMES CONTAIN SURFACE

5277
03:18:46,080 --> 03:18:48,680
PROTEINS, ALLOWING IT TO TARGET

5278
03:18:48,680 --> 03:18:51,480
TO SPECIFIC CELL TYPES TO ALLOW

5279
03:18:51,480 --> 03:18:52,520
SPECIFIC COMMUNICATION BETWEEN

5280
03:18:52,520 --> 03:18:54,800
DIFFERENT CELLS.

5281
03:18:54,800 --> 03:18:55,920
AND DIFFERENT MILIEU.

5282
03:18:55,920 --> 03:18:58,320
I THINK WE HEARD FROM TARA

5283
03:18:58,320 --> 03:19:01,480
SCHWETZ EARLIER ABOUT ARPA H AND

5284
03:19:01,480 --> 03:19:02,680
WANT OF THE INTERESTS IN

5285
03:19:02,680 --> 03:19:05,040
MOLECULAR ZIP CODES, WE HAVE

5286
03:19:05,040 --> 03:19:09,280
EXOSOMES THAT ARE NOT POPULATED

5287
03:19:09,280 --> 03:19:11,240
WITH CELL SPECIFIC OR TISSUE

5288
03:19:11,240 --> 03:19:12,280
SPECIFIC MOLECULAR ZIP CODES

5289
03:19:12,280 --> 03:19:17,280
THAT ALLOW TO ZOOM IN WITH

5290
03:19:17,280 --> 03:19:20,000
SPECIFIC TARGETS.

5291
03:19:20,000 --> 03:19:21,880
IT HAS BEEN RECOGNIZED IMPORTANT

5292
03:19:21,880 --> 03:19:23,480
AS INTRACELLULAR SIGNALING

5293
03:19:23,480 --> 03:19:28,000
MOLECULES EXSOMES CAN BE USED TO

5294
03:19:28,000 --> 03:19:31,960
REPAIR TISSUE INHERENTLY IN ITS

5295
03:19:31,960 --> 03:19:34,280
OWN OR BECAUSE YOU CAN ACTUALLY

5296
03:19:34,280 --> 03:19:36,280
MANIPULATE NOT ONLY SURFACE

5297
03:19:36,280 --> 03:19:38,280
MARKERS BUT ALSO MANIPULATE

5298
03:19:38,280 --> 03:19:40,280
CARGO, YOU CAN LOAD UP WITH

5299
03:19:40,280 --> 03:19:41,960
VARIOUS THERAPEUTIC CARGOES SUCH

5300
03:19:41,960 --> 03:19:48,760
AS PROTEINS, GENE THERAPIES AN

5301
03:19:48,760 --> 03:19:53,280
VACCINES TO ALLOW SPECIFIC

5302
03:19:53,280 --> 03:19:55,840
TARGETING WITH MINIMIZING ANY

5303
03:19:55,840 --> 03:20:01,560
UNDUE EFFECTS IN THE TISSUE.

5304
03:20:01,560 --> 03:20:02,760
MENTION SLIDE.

5305
03:20:02,760 --> 03:20:03,160
NEXT SLIDE.

5306
03:20:03,160 --> 03:20:04,480
THIS IS A IN U CONCEPT

5307
03:20:04,480 --> 03:20:07,160
CLEARANCE, IT SAYS EXOSOME

5308
03:20:07,160 --> 03:20:10,200
THERAPEUTICS FOR REGENERATIVE

5309
03:20:10,200 --> 03:20:14,480
MEDICINE, DR. HAPPEL WILL DO THE

5310
03:20:14,480 --> 03:20:14,880
PRESENTATION.

5311
03:20:14,880 --> 03:20:17,880
SO SHE HAS A Ph.D. IN GENETICS

5312
03:20:17,880 --> 03:20:19,080
FROM THEM IT WILL UNIVERSITY

5313
03:20:19,080 --> 03:20:20,920
SCHOOL OF MEDICINE, SHE RECEIVED

5314
03:20:20,920 --> 03:20:28,200
THE RUTH KIRSTEIN POST-DOCTORAL

5315
03:20:28,200 --> 03:20:30,400
FELLOWSHIP AT HOPKINS WORKING ON

5316
03:20:30,400 --> 03:20:32,880
MICRORNA REGULATION AS WELL AS

5317
03:20:32,880 --> 03:20:36,920
DOING SECOND POST-DOC AT NCI.

5318
03:20:36,920 --> 03:20:38,840
SO CHRISTINE WILL BE TALKING A

5319
03:20:38,840 --> 03:20:40,480
LITTLE BIT MORE IN DETAIL ABOUT

5320
03:20:40,480 --> 03:20:41,680
THIS CONCEPT CLEARANCE.

5321
03:20:41,680 --> 03:20:43,760
SO I WILL TURN IT TO YOU,

5322
03:20:43,760 --> 03:20:45,480
CHRISTINE.

5323
03:20:45,480 --> 03:20:50,080
>> THANK YOU.

5324
03:20:50,080 --> 03:20:52,840
THIS IS A NEW CONCEPT THAT WE

5325
03:20:52,840 --> 03:20:58,920
ARE PROPOSING FOR NICELY NAMED

5326
03:20:58,920 --> 03:21:02,080
EXTREME.

5327
03:21:02,080 --> 03:21:06,480
NEXT SLIDE PLEASE.

5328
03:21:06,480 --> 03:21:08,600
DESPITE SUCCESS IN REGENERATIVE

5329
03:21:08,600 --> 03:21:09,880
MEDICINE MAJOR CHALLENGES ARE

5330
03:21:09,880 --> 03:21:10,880
MAIN IN THE FIELD.

5331
03:21:10,880 --> 03:21:12,960
STEM CELL TRANSPLANTATION

5332
03:21:12,960 --> 03:21:16,080
CURRENTLY MAIN METHOD FOR TISSUE

5333
03:21:16,080 --> 03:21:19,480
REGENERATION PROGRESS IS LIMITED

5334
03:21:19,480 --> 03:21:21,280
HURDLES INCLUDE RELIABLE CELL

5335
03:21:21,280 --> 03:21:23,280
SOURCE TUMOR FORMATION,

5336
03:21:23,280 --> 03:21:24,920
INAPPROPRIATE STEM CELL

5337
03:21:24,920 --> 03:21:26,920
MIGRATION, IMMUNE REJECTION OF

5338
03:21:26,920 --> 03:21:31,160
TRANSPLANTED STEM CELLS,

5339
03:21:31,160 --> 03:21:32,720
COMPLICATIONS DURING SURGERY AND

5340
03:21:32,720 --> 03:21:33,480
POST-OPERATIVE INFECTION.

5341
03:21:33,480 --> 03:21:36,000
WITH THIS CONCEPT NCATS PROPOSES

5342
03:21:36,000 --> 03:21:38,240
A NOVEL EXSOME BASED

5343
03:21:38,240 --> 03:21:40,320
THERAPEUTICS PROGRAM TO CATALYZE

5344
03:21:40,320 --> 03:21:43,560
REGENERATIVE MEDICINE CREATING A

5345
03:21:43,560 --> 03:21:46,000
THERAPEUTIC SO AS SEEN ON THE

5346
03:21:46,000 --> 03:21:47,800
SCHEMATIC ON THE RIGHT EXOSOMES

5347
03:21:47,800 --> 03:21:49,360
ARE SMALL ENDOGENOUS MEMBRANE

5348
03:21:49,360 --> 03:21:51,280
ENCLOSED CARRIERS.

5349
03:21:51,280 --> 03:21:52,840
ABOUT THE SIZE OF VIRUS

5350
03:21:52,840 --> 03:21:53,200
PARTICLE.

5351
03:21:53,200 --> 03:21:55,520
AND AS DAN SAID THEY CONTAIN

5352
03:21:55,520 --> 03:21:57,480
BIOACTIVE PROTEIN LIPIDS AND

5353
03:21:57,480 --> 03:21:59,920
NUCLEIC ACIDS, FOR INTRACELLULAR

5354
03:21:59,920 --> 03:22:04,400
COMMUNICATION.

5355
03:22:04,400 --> 03:22:06,160
EXOSOME BASED COMMUNICATION

5356
03:22:06,160 --> 03:22:08,640
OCCURS IN A BIDIRECTIONAL MANNER

5357
03:22:08,640 --> 03:22:09,960
AND TAKE PLACE DURING NORMAL

5358
03:22:09,960 --> 03:22:11,680
CELL HOMEOSTASIS AND CONSEQUENCE

5359
03:22:11,680 --> 03:22:13,560
OF PATHOLOGICAL DEVELOPMENT.

5360
03:22:13,560 --> 03:22:16,080
SO THE SCHEMATIC SHOWN HERE

5361
03:22:16,080 --> 03:22:18,320
SHOWS SIGNALING BETWEEN DISEASE

5362
03:22:18,320 --> 03:22:20,280
CELL AND STEM CELL WHERE DISEASE

5363
03:22:20,280 --> 03:22:23,080
CELL IS INDICATING DISTRESS.

5364
03:22:23,080 --> 03:22:25,720
THE STEM CELL THEN RESPONDS BY

5365
03:22:25,720 --> 03:22:26,680
RELEASING SPECIFIC REPAIR

5366
03:22:26,680 --> 03:22:30,280
EXSOMES.

5367
03:22:30,280 --> 03:22:33,160
WHAT MAKES THIS CONCEPT PARADIGM

5368
03:22:33,160 --> 03:22:36,680
SHIFT IS THAT UTILIZES

5369
03:22:36,680 --> 03:22:38,400
NON-LIVING CELLULAR PRODUCT

5370
03:22:38,400 --> 03:22:39,280
RATHER THAN STEM CELLS

5371
03:22:39,280 --> 03:22:40,840
THEMSELVES TO PROMOTE TISSUE

5372
03:22:40,840 --> 03:22:46,240
REGENERATION.

5373
03:22:46,240 --> 03:22:48,240
THERAPIES TO PROMOTE TISSUE

5374
03:22:48,240 --> 03:22:49,320
REPAIR A WOUND HEALING

5375
03:22:49,320 --> 03:22:53,480
TRANSLATED TO THE CLINIC.

5376
03:22:53,480 --> 03:22:55,080
EXTREME KNOWLEDGE RESOURCES

5377
03:22:55,080 --> 03:22:56,760
DEVELOPED BY COMMON FUND EXTRA

5378
03:22:56,760 --> 03:22:58,720
CELLULAR RNA COMMUNICATION

5379
03:22:58,720 --> 03:23:01,480
PROGRAM WHICH LOOK AT EXTRA

5380
03:23:01,480 --> 03:23:03,600
CELLULAR RNA CARRIERS SUCH AS

5381
03:23:03,600 --> 03:23:05,480
EXSOMES, AS CRITICAL MEDIATORS

5382
03:23:05,480 --> 03:23:07,880
OF INTRACELLULAR COMMUNICATION.

5383
03:23:07,880 --> 03:23:10,080
ALSO BUILD OFF RECENTLY

5384
03:23:10,080 --> 03:23:11,240
CONCLUDED COMMON FUND

5385
03:23:11,240 --> 03:23:15,640
REGENERATIVE MEDICINE PROGRAM,

5386
03:23:15,640 --> 03:23:18,280
AND LEVERAGE EXPERTISE OF NCATS

5387
03:23:18,280 --> 03:23:19,160
STEM CELL TRANSLATION

5388
03:23:19,160 --> 03:23:19,800
LABORATORY.

5389
03:23:19,800 --> 03:23:25,120
NEXT SLIDE.

5390
03:23:25,120 --> 03:23:26,800
SO THE OBJECTIVE OF THIS PROGRAM

5391
03:23:26,800 --> 03:23:29,000
IS TRANSFORM REGENERATIVE

5392
03:23:29,000 --> 03:23:30,240
MEDICINE THROUGH NOVEL EXOSOME

5393
03:23:30,240 --> 03:23:32,440
BASED THERAPEUTIC AND TISSUE

5394
03:23:32,440 --> 03:23:33,920
REPAIR WOUND HEALING.

5395
03:23:33,920 --> 03:23:35,680
AS SOON IN THE SCHEMATIC ON THE

5396
03:23:35,680 --> 03:23:39,480
RIGHT THERE ARE TWO WAYS THIS

5397
03:23:39,480 --> 03:23:41,000
CAN BE ACHIEVED.

5398
03:23:41,000 --> 03:23:44,240
THE PERSON HAS DIRECT EXOSOME

5399
03:23:44,240 --> 03:23:48,280
THERAPY WHICH UTILIZES EXOSOMES

5400
03:23:48,280 --> 03:23:50,840
ISOLATED STEM CELLS STORED AS

5401
03:23:50,840 --> 03:23:52,520
OFFICE THERAPY TO BE INFUSED IN

5402
03:23:52,520 --> 03:23:53,480
PATIENTS.

5403
03:23:53,480 --> 03:23:57,080
SO AN EXAMPLE OF DIRECT EXOSOME

5404
03:23:57,080 --> 03:23:59,200
THERAPY, WE FOUND RECENT

5405
03:23:59,200 --> 03:24:00,880
PUBLICATION WHERE THEY

5406
03:24:00,880 --> 03:24:02,720
DEMONSTRATED ENDOTHELIAL CELL

5407
03:24:02,720 --> 03:24:05,160
DERIVED EXOSOMES WERE ABLE TO

5408
03:24:05,160 --> 03:24:08,880
INDUCE CARDIAC TISSUE REPAIR,

5409
03:24:08,880 --> 03:24:11,680
FOLLOWING ISCHEMIC REPROFUSION

5410
03:24:11,680 --> 03:24:14,080
INJURY BY SUPPLEMENTING NEARBY

5411
03:24:14,080 --> 03:24:16,080
CELLS BY PROTEINS WITH CRITICAL

5412
03:24:16,080 --> 03:24:18,560
CELLULAR PROCESSES.

5413
03:24:18,560 --> 03:24:20,760
THE SECOND WAY THIS CAN BE

5414
03:24:20,760 --> 03:24:22,920
ACHIEVE IS THROUGH DESIGN

5415
03:24:22,920 --> 03:24:24,280
EVERYBODY EXOSOMES WHICH IS

5416
03:24:24,280 --> 03:24:25,080
PERSONALIZED ACCORDING TO

5417
03:24:25,080 --> 03:24:27,680
INDIVIDUAL PATIENT NEEDS.

5418
03:24:27,680 --> 03:24:31,480
THIS MEANS STEM CELL CELLS ARE

5419
03:24:31,480 --> 03:24:33,680
HARVESTED FROM PATIENT EXPANDED

5420
03:24:33,680 --> 03:24:35,360
AND MODIFIED BASED ON NEEDS

5421
03:24:35,360 --> 03:24:36,600
FOLLOWED BY GENERATION OF

5422
03:24:36,600 --> 03:24:38,160
EXOSOMES THAT ARE INFUSED BACK

5423
03:24:38,160 --> 03:24:41,520
INTO THE SAME PATIENT.

5424
03:24:41,520 --> 03:24:43,720
MODIFICATIONS INCLUDE GENETIC

5425
03:24:43,720 --> 03:24:46,080
MODIFICATION, ADDITION OF

5426
03:24:46,080 --> 03:24:48,920
THERAPEUTIC SMALL MOLECULES OR

5427
03:24:48,920 --> 03:24:50,840
CELL SURFACE RECEPTORS FOR

5428
03:24:50,840 --> 03:24:54,080
SPECIFIC EXOSOME TARGETING.

5429
03:24:54,080 --> 03:24:56,840
WE ANTICIPATE EXTREME ENCOMPASS

5430
03:24:56,840 --> 03:24:58,200
KEY AREAS OF EXOSOME

5431
03:24:58,200 --> 03:24:59,880
THERAPEUTICS.

5432
03:24:59,880 --> 03:25:01,640
DIRECT EXOSOME THERAPY, WOULD BE

5433
03:25:01,640 --> 03:25:08,400
MORMORE ACHIEVEABLE, DESIGNER

5434
03:25:08,400 --> 03:25:09,800
EXOSOMES PUSH ENVELOPE IN WHAT

5435
03:25:09,800 --> 03:25:16,320
CAN BE ACHIEVED.

5436
03:25:16,320 --> 03:25:18,320
IMPLEMENTATION OF THIS CONCEPT

5437
03:25:18,320 --> 03:25:21,880
INCLUDES FOCUS ON IND ENABLING

5438
03:25:21,880 --> 03:25:23,000
THERAPEUTICS AND ENTAIL EARLY

5439
03:25:23,000 --> 03:25:25,200
ENGAGEMENT WITH THE FDA TOWARD

5440
03:25:25,200 --> 03:25:28,560
REGULATORY APPROVAL.

5441
03:25:28,560 --> 03:25:31,440
UTILIZE A MILESTONE DRIVEN

5442
03:25:31,440 --> 03:25:34,760
APPROACH TOWARD THESE

5443
03:25:34,760 --> 03:25:36,120
THERAPEUTICS TRANSLATED TO

5444
03:25:36,120 --> 03:25:39,320
CLINIC, A CONSORTIUM OF FUNDED

5445
03:25:39,320 --> 03:25:40,880
INVESTIGATORS TO FACILITATE

5446
03:25:40,880 --> 03:25:46,040
SHARING RESOURCES AND EXPERTISE.

5447
03:25:46,040 --> 03:25:48,200
METRICS INCLUDE DEMONSTRATION OF

5448
03:25:48,200 --> 03:25:50,200
ABILITY TO REGENERATE DISEASE

5449
03:25:50,200 --> 03:25:51,680
ORGANS, FROM MANY HUMAN

5450
03:25:51,680 --> 03:25:53,440
DISORDERS AND THE VALIDATION OF

5451
03:25:53,440 --> 03:25:55,520
THESE THERAPEUTICS BENEFITS IN

5452
03:25:55,520 --> 03:25:57,360
VIVO OR EXVIVO.

5453
03:25:57,360 --> 03:25:59,800
SO THIS WOULD INCLUDE A

5454
03:25:59,800 --> 03:26:02,000
KNOWLEDGE OF SPECIFIC STEM CELL

5455
03:26:02,000 --> 03:26:03,880
DERIVED EXOSOME TO ENDEUCE

5456
03:26:03,880 --> 03:26:05,880
REPAIR AND WOUND HEALING AT

5457
03:26:05,880 --> 03:26:09,120
SPECIFIC TARGET ORGANS.

5458
03:26:09,120 --> 03:26:10,800
FINALLY WE EXPECT THAT THE

5459
03:26:10,800 --> 03:26:13,000
RESEARCH ACTIVITIES AND RESULTS

5460
03:26:13,000 --> 03:26:14,240
SPUR NUMBER OF COMMERCIAL

5461
03:26:14,240 --> 03:26:15,600
ACTIVITIES BEYOND INITIAL NCATS

5462
03:26:15,600 --> 03:26:18,480
INVESTMENTMENINVESTMENT.

5463
03:26:18,480 --> 03:26:22,280
NEXT SLIDE.

5464
03:26:22,280 --> 03:26:28,160
IN SUMMARY, EXOSOMES REPRESENT

5465
03:26:28,160 --> 03:26:29,880
THE THERAPY DUE TO NATURAL

5466
03:26:29,880 --> 03:26:31,440
FUNCTION AS MEDIATORS OF TISSUE

5467
03:26:31,440 --> 03:26:32,800
REPAIR AND WOUND HAILING.

5468
03:26:32,800 --> 03:26:34,400
NCATS PROPOSES THIS CONCEPT TO

5469
03:26:34,400 --> 03:26:36,240
TRANSFORM REGENERATIVE MEDICINE

5470
03:26:36,240 --> 03:26:37,720
APPROACHES THROUGH THESE NOVEL

5471
03:26:37,720 --> 03:26:40,680
EXOSOME BASED THERAPEUTICS,

5472
03:26:40,680 --> 03:26:41,720
CREATING A BUT THERAPEUTIC

5473
03:26:41,720 --> 03:26:43,360
PARADIGM.

5474
03:26:43,360 --> 03:26:45,200
THIS CONCEPT WOULD DEVELOP CELL

5475
03:26:45,200 --> 03:26:47,120
DERIVED HE CANSOME BASED

5476
03:26:47,120 --> 03:26:48,480
THERAPEUTICS FOR REGULATORY

5477
03:26:48,480 --> 03:26:49,920
APPROVAL AND TRANSLATION INTO

5478
03:26:49,920 --> 03:26:51,640
THE CLINIC TO THE BENEFIT OF

5479
03:26:51,640 --> 03:26:58,520
PATIENTS.  WITH THAT WE WILL

5480
03:26:58,520 --> 03:27:00,600
BRING UP OUR QUESTIONS FOR

5481
03:27:00,600 --> 03:27:01,200
COUNCIL FOR DISCUSSION.

5482
03:27:01,200 --> 03:27:01,480
THANK YOU.

5483
03:27:01,480 --> 03:27:10,120
T

5484
03:27:10,120 --> 03:27:13,400
>> WE HAVE A COUPLE OF

5485
03:27:13,400 --> 03:27:14,000
DISCUSSANTS.

5486
03:27:14,000 --> 03:27:14,960
ANNIE WOULD YOU LIKE TO GO

5487
03:27:14,960 --> 03:27:18,480
FIRST?

5488
03:27:18,480 --> 03:27:20,520
>> I DON'T KNOW THAT I CAN

5489
03:27:20,520 --> 03:27:21,240
COMMENT ON THE SCIENCE ITSELF

5490
03:27:21,240 --> 03:27:22,800
THAT WAS DESCRIBED BUT I THINK

5491
03:27:22,800 --> 03:27:25,240
ONE OF THE THINGS AS I WAS

5492
03:27:25,240 --> 03:27:28,080
READING THIS PROPOSAL OVER THE

5493
03:27:28,080 --> 03:27:32,240
WEEKEND STRUCK BY WAS FIRST I

5494
03:27:32,240 --> 03:27:38,120
APPRECIATE THE INNOVATION NATURE

5495
03:27:38,120 --> 03:27:39,160
OF PERSONALIZED MEDICINE.

5496
03:27:39,160 --> 03:27:40,960
ONE OF THE THINGS THAT WE TALKED

5497
03:27:40,960 --> 03:27:41,960
ABOUT HERE ALREADY TODAY WE

5498
03:27:41,960 --> 03:27:44,920
TALKED ABOUT PREVIOUSLY, WAS AS

5499
03:27:44,920 --> 03:27:52,440
YOU ARTICULATED THE METRICS

5500
03:27:52,440 --> 03:27:53,480
DEMONSTRATION ABILITY TO REPAIR

5501
03:27:53,480 --> 03:27:54,920
DISEASED ORGANS FROM HUMAN

5502
03:27:54,920 --> 03:27:56,600
DISORDERS AND VALIDATION OF

5503
03:27:56,600 --> 03:27:58,080
THERAPEUTIC BENEFITS.

5504
03:27:58,080 --> 03:28:02,680
AND I JUST WONDERING IF SPECIFIC

5505
03:28:02,680 --> 03:28:04,320
TO THIS PROJECT AND PROGRAM IF

5506
03:28:04,320 --> 03:28:06,400
WE SHOULDN'T BE THINKING ABOUT

5507
03:28:06,400 --> 03:28:08,720
NCATS CHARGE AS BEING BEYOND

5508
03:28:08,720 --> 03:28:11,080
JUST REGULATORY APPROVAL AT THE

5509
03:28:11,080 --> 03:28:11,480
FDA?

5510
03:28:11,480 --> 03:28:16,080
BUT THINKING ABOUT DECISIONS NOW

5511
03:28:16,080 --> 03:28:18,880
HAPPENING WITHIN CMS.

5512
03:28:18,880 --> 03:28:20,680
AND HOW IF YOU THINK ABOUT

5513
03:28:20,680 --> 03:28:23,240
CONSORTIUM YOU BRING TOGETHER

5514
03:28:23,240 --> 03:28:25,480
STAKEHOLDERS AND BUILDING ON THE

5515
03:28:25,480 --> 03:28:26,360
PARADIGM YOU ARE THINKING ABOUT

5516
03:28:26,360 --> 03:28:28,680
WHAT THE IMPLICATIONS FOR THIS

5517
03:28:28,680 --> 03:28:32,600
WILL BE WITHIN THE ENVIRONMENT,

5518
03:28:32,600 --> 03:28:34,160
HOW -- WHAT OUTCOMES YOU ARE

5519
03:28:34,160 --> 03:28:35,240
LOOKING FOR AS YOU STRUCTURE

5520
03:28:35,240 --> 03:28:40,120
THIS TO SHOW THAT BENEFITS IN

5521
03:28:40,120 --> 03:28:41,800
VIVO EXVIVO ARE BETTER THAN WHAT

5522
03:28:41,800 --> 03:28:43,840
IS AVAILABLE NOW REIMBURSED

5523
03:28:43,840 --> 03:28:44,480
SUCH.

5524
03:28:44,480 --> 03:28:46,160
SO JUST SOME THINGS FOR

5525
03:28:46,160 --> 03:28:47,680
CONSIDERATION AS YOU ARE

5526
03:28:47,680 --> 03:28:48,600
BUILDING OUT THE SCOPE OF THIS

5527
03:28:48,600 --> 03:28:50,480
AND WE ARE THINKING WHICH

5528
03:28:50,480 --> 03:28:52,080
PARTNER SO THAT WOULD BE

5529
03:28:52,080 --> 03:28:52,920
DEPENDENT WHICH DISEASE

5530
03:28:52,920 --> 03:28:54,080
COMMUNITIES WHETHER YOU ARE

5531
03:28:54,080 --> 03:28:55,240
THINKING ABOUT MEDICARE

5532
03:28:55,240 --> 03:28:57,760
STRUCTURE OR MEDICAID STRUCTURE,

5533
03:28:57,760 --> 03:28:59,800
OR MORE COMMERCIAL ENTITIES.

5534
03:28:59,800 --> 03:29:01,040
SO JUST SOMETHING TO THINK ABOUT

5535
03:29:01,040 --> 03:29:03,680
MORE BROADLY.

5536
03:29:03,680 --> 03:29:08,680
AND THEN OBVIOUSLY DATA SHARING

5537
03:29:08,680 --> 03:29:09,920
COMPONENTS WHICH WE ALSO TALK

5538
03:29:09,920 --> 03:29:11,160
ABOUT WOULD BE INCREDIBLY

5539
03:29:11,160 --> 03:29:13,160
IMPORTANT TO CONSIDER.

5540
03:29:13,160 --> 03:29:15,640
THOSE WERE MY ONLY COMMENTS ALSO

5541
03:29:15,640 --> 03:29:17,160
EXTEND MORE BROADLY TO OTHER

5542
03:29:17,160 --> 03:29:18,040
PROGRAMS WE ARE CONSIDERING AS

5543
03:29:18,040 --> 03:29:29,000
WELL.

5544
03:29:29,000 --> 03:29:30,480
WE ARE THINKING ABOUT ACCESS

5545
03:29:30,480 --> 03:29:30,920
NOW.

5546
03:29:30,920 --> 03:29:31,520
NEVER TOO EARLY.

5547
03:29:31,520 --> 03:29:32,840
WE ARE THINKING ABOUT PROGRAM

5548
03:29:32,840 --> 03:29:34,280
AND HA IS A FANTASTIC WAY TO

5549
03:29:34,280 --> 03:29:35,560
KEEP OUR EYE ON THAT BALL.

5550
03:29:35,560 --> 03:29:44,080
I APPRECIATE THAT COMMENT.

5551
03:29:44,080 --> 03:29:46,680
>> VERY INSIGHTFUL QUESTIONS AND

5552
03:29:46,680 --> 03:29:47,880
THINGS WE WILL KEEP IN MIND AS

5553
03:29:47,880 --> 03:29:48,480
WE MOVE FORWARD.

5554
03:29:48,480 --> 03:29:51,960
THEY ARE VERY IMPORTANT BIG

5555
03:29:51,960 --> 03:29:53,040
PICTURE SUGGESTIONS, THANK YOU,

5556
03:29:53,040 --> 03:29:57,080
THAT'S HELPFUL.

5557
03:29:57,080 --> 03:29:59,680
>> KRISTINA, I THINK I CAN

5558
03:29:59,680 --> 03:30:01,320
COMPLIMENT THIS I WILL BE A

5559
03:30:01,320 --> 03:30:03,360
LITTLE MORE ON THE TAKING A

5560
03:30:03,360 --> 03:30:04,400
MOLECULAR BIOLOGY ASPECT.

5561
03:30:04,400 --> 03:30:07,600
I THINK VERY HIGHLY, RNA

5562
03:30:07,600 --> 03:30:10,160
CONSORTIUM HAS DONE A TREMENDOUS

5563
03:30:10,160 --> 03:30:14,240
JOB IN DEFINING ALL THE METHOD

5564
03:30:14,240 --> 03:30:17,560
LOGICAL CONSTRAINT IN THAT

5565
03:30:17,560 --> 03:30:27,560
SPACE, AND ASSETS LEVERAGE --

5566
03:30:27,560 --> 03:30:28,960
OBVIOUSLY WE HAVE SEEN SPECIFIC

5567
03:30:28,960 --> 03:30:32,400
SUCCESSES WITH THESE TYPE OF

5568
03:30:32,400 --> 03:30:35,720
INTERVENTIONS, FROM BASIC

5569
03:30:35,720 --> 03:30:39,480
SCIENCE APPROACH, MY CONCERN

5570
03:30:39,480 --> 03:30:44,120
STRATEGIES THAT IT IS BLACK BOX

5571
03:30:44,120 --> 03:30:44,880
APPROACH.

5572
03:30:44,880 --> 03:30:48,640
YOU TRANSFER BIOLOGICAL ACTIVITY

5573
03:30:48,640 --> 03:30:50,640
WITHOUT CHARACTERIZATION OF

5574
03:30:50,640 --> 03:30:52,440
BIOLOGICAL ACTIVITY INTO VARIOUS

5575
03:30:52,440 --> 03:30:53,800
DISEASE SETTINGS.

5576
03:30:53,800 --> 03:30:59,000
AND WHY THIS APPROACH CAN BE

5577
03:30:59,000 --> 03:31:01,400
SUCCESSFUL A NEPHROLOGIST WHO

5578
03:31:01,400 --> 03:31:03,240
HAS DONEPHORESES TREATMENTS AND

5579
03:31:03,240 --> 03:31:04,720
STUDIES, IT REMAINS BLACK BOX.

5580
03:31:04,720 --> 03:31:06,400
YOU WILL HAVE RESPONDERS AND

5581
03:31:06,400 --> 03:31:07,960
NON-RESPONDERS AND IT WILL BE

5582
03:31:07,960 --> 03:31:09,560
DIFFICULT OR IMPOSSIBLE TO

5583
03:31:09,560 --> 03:31:12,920
DEFINE WHO IS RESPONDING AND FOR

5584
03:31:12,920 --> 03:31:13,760
WHAT REASON.

5585
03:31:13,760 --> 03:31:15,080
THE SCIENCE HAS MOVED FORWARD AS

5586
03:31:15,080 --> 03:31:17,440
WE DISCUSSED EARLIER WE HAVE NOW

5587
03:31:17,440 --> 03:31:19,760
AN OPPORTUNITY TO ACTUALLY KNOW

5588
03:31:19,760 --> 03:31:22,880
THE BAR CODES, YOUR VESICLES ARE

5589
03:31:22,880 --> 03:31:24,400
HEADING TOWARDS.

5590
03:31:24,400 --> 03:31:27,120
YOU CAN SELECT AND DESIGN YOUR

5591
03:31:27,120 --> 03:31:30,120
VESICALES, YOUR VESICLE SORT AND

5592
03:31:30,120 --> 03:31:32,480
TYPE GETS PREDEFINED AND

5593
03:31:32,480 --> 03:31:35,440
CONTENTS CAN BE DEFINED AS WELL.

5594
03:31:35,440 --> 03:31:37,960
WHILE THIS MIGHT BE NOT IN SCOPE

5595
03:31:37,960 --> 03:31:40,840
OF THE SPECIFIC OPPORTUNITY I AT

5596
03:31:40,840 --> 03:31:43,360
LEAST WOULD DESIGN OPPORTUNITY

5597
03:31:43,360 --> 03:31:46,440
SUCH THAT THIS MORE TARGETED

5598
03:31:46,440 --> 03:31:49,800
APPROACH CAN BE DEVELOPED OUT OF

5599
03:31:49,800 --> 03:31:50,680
CLINICAL IMPLEMENTATION STRATEGY

5600
03:31:50,680 --> 03:31:53,360
SO WILL IS A AN ARM BUILT IN

5601
03:31:53,360 --> 03:31:56,480
WHEN THE VESICALES ARE

5602
03:31:56,480 --> 03:31:58,920
TRANSFERRED AND DEFINED

5603
03:31:58,920 --> 03:32:00,800
RESPONSES WHICH THE TECHNOLOGIES

5604
03:32:00,800 --> 03:32:04,640
I THINK ARE THERE NOW BASED ON O

5605
03:32:04,640 --> 03:32:05,880
CONSORTIUM EFFORT YOU CAN

5606
03:32:05,880 --> 03:32:07,160
DAPTURE WHO IS RESPONDING AND

5607
03:32:07,160 --> 03:32:10,120
WHAT VESICAL -- CAPTURE WHO

5608
03:32:10,120 --> 03:32:12,480
RESPONDING AND WHAT VESICLE

5609
03:32:12,480 --> 03:32:13,360
RESPONDS TO MENTION STAGE

5610
03:32:13,360 --> 03:32:15,160
TOWARDS MOLECULAR DEFINED

5611
03:32:15,160 --> 03:32:19,480
INTERVENTIONS.

5612
03:32:19,480 --> 03:32:21,240
OBVIOUSLY VESICALLY TARGETING

5613
03:32:21,240 --> 03:32:22,200
TRANSCRIPTS WE HAVE SOME OF

5614
03:32:22,200 --> 03:32:23,880
THOSE INTO OUR SHOULDERS

5615
03:32:23,880 --> 03:32:25,360
RECENTLY.

5616
03:32:25,360 --> 03:32:28,120
AND THEY HAVE BEEN MAJOR BREAK

5617
03:32:28,120 --> 03:32:31,040
THROUGH AND FULL DISCLOSURE WE

5618
03:32:31,040 --> 03:32:32,720
ARE WRITING WITH SUCH ENTITIES

5619
03:32:32,720 --> 03:32:34,480
TO TARGET VESICALES TOWARDS

5620
03:32:34,480 --> 03:32:36,280
SPECIFIC CELLS AND SPECIFIC

5621
03:32:36,280 --> 03:32:36,800
DISEASES.

5622
03:32:36,800 --> 03:32:40,240
SO IN A SINGLE MOLECULE DEFINE

5623
03:32:40,240 --> 03:32:42,480
APPROACH ALREADY MOVING FORWARD

5624
03:32:42,480 --> 03:32:46,720
BUT YOU STRATEGY MIGHT BE

5625
03:32:46,720 --> 03:32:49,880
INTERMEDIATE SPACE WHERE YOU CAN

5626
03:32:49,880 --> 03:32:51,000
UNDERSTAND WHERE BIOLOGY

5627
03:32:51,000 --> 03:32:52,680
LEVERAGING PRINCIPLE TO COMMENT

5628
03:32:52,680 --> 03:32:54,240
TOWARDS MOLECULAR CHEMICALLY

5629
03:32:54,240 --> 03:32:55,280
DEFINED APPROACH.

5630
03:32:55,280 --> 03:32:57,240
SO CERTAINLY MOVE FORWARD.

5631
03:32:57,240 --> 03:32:59,120
BUT TRY TO BUILD DISCOVERY

5632
03:32:59,120 --> 03:33:02,520
COMPONENT IN TO THE

5633
03:33:02,520 --> 03:33:07,120
TRANSLATIONAL ASPECT

5634
03:33:07,120 --> 03:33:07,480
INCENTIVIZING.

5635
03:33:07,480 --> 03:33:08,880
>> THANK YOU FOR THOSE COMMENTS.

5636
03:33:08,880 --> 03:33:09,480
CHRISTINE.

5637
03:33:09,480 --> 03:33:09,920
DO YOU WANT TO --

5638
03:33:09,920 --> 03:33:10,880
>> YEAH.

5639
03:33:10,880 --> 03:33:13,360
THANK YOU FOR THOSE COMMENTS.

5640
03:33:13,360 --> 03:33:14,920
I THINK YOU ARE CERTAINLY RIGHT

5641
03:33:14,920 --> 03:33:18,120
IN THAT RIGHT NOW THESE --

5642
03:33:18,120 --> 03:33:20,080
PEOPLE ARE STARTING TO GET TO

5643
03:33:20,080 --> 03:33:22,280
THIS AREA AND RIGHT NOW IT IS A

5644
03:33:22,280 --> 03:33:24,520
LITTLE BIT LIKE BLACK BOX BUT

5645
03:33:24,520 --> 03:33:28,720
THAT IS WHY I THINK NCATS IS SO

5646
03:33:28,720 --> 03:33:31,600
WELL-POSITIONED TO DIVE IN AND

5647
03:33:31,600 --> 03:33:34,880
MAKE SIGNIFICANT IMPROVEMENTS.

5648
03:33:34,880 --> 03:33:36,480
BECAUSE WE ARE LEVERAGING A LOT

5649
03:33:36,480 --> 03:33:38,280
OF VERY NEW TECHNOLOGIES THAT

5650
03:33:38,280 --> 03:33:40,000
HAVE BEEN DEVELOPED.

5651
03:33:40,000 --> 03:33:42,680
SO THE M CATS STEM CELL

5652
03:33:42,680 --> 03:33:46,480
LABORATORY THEY ARE WELL -- VERY

5653
03:33:46,480 --> 03:33:48,960
WELL EXPERIENCED IN STEM CELL

5654
03:33:48,960 --> 03:33:49,440
ISOLATION.

5655
03:33:49,440 --> 03:33:53,240
SO WE CAN UTILIZE THEIR

5656
03:33:53,240 --> 03:33:58,880
EXPERTISE TO GENERATE WELL

5657
03:33:58,880 --> 03:34:05,720
CHARACTERIZED SOURCES OF THESE

5658
03:34:05,720 --> 03:34:07,960
STEM CELL EXOSOMES AND UTILIZE

5659
03:34:07,960 --> 03:34:08,960
KNOWLEDGE FROM EXTRA CELLULAR

5660
03:34:08,960 --> 03:34:12,440
RNA COMMUNICATION PROGRAM AN

5661
03:34:12,440 --> 03:34:13,480
EXOSOME LYSE ICE LAKES METHODS

5662
03:34:13,480 --> 03:34:15,560
THEY DEVELOPED, TO REALLY

5663
03:34:15,560 --> 03:34:17,560
CONTRIBUTE TO MAKING SOME VERY

5664
03:34:17,560 --> 03:34:24,960
WELL CHARACTERIZED EXOSOME

5665
03:34:24,960 --> 03:34:26,600
SOURCES BY PIECING ALL THESE

5666
03:34:26,600 --> 03:34:27,600
DIFFERENT TECHNOLOGIES THAT HAVE

5667
03:34:27,600 --> 03:34:31,040
BEEN DEVELOPED SO UTILIZING THE

5668
03:34:31,040 --> 03:34:32,800
PRODUCTION OF WELL CHARACTERIZED

5669
03:34:32,800 --> 03:34:36,760
STEM CELLS FROM A STEM CELLS

5670
03:34:36,760 --> 03:34:39,640
TRANSLATION LABORATORY UTILIZING

5671
03:34:39,640 --> 03:34:42,640
EXOSOME ISOLATION TECHNOLOGY

5672
03:34:42,640 --> 03:34:44,280
FROM EXC CELLULAR COMMUNICATION

5673
03:34:44,280 --> 03:34:45,320
PROGRAM AND ALSO SOME OF THE

5674
03:34:45,320 --> 03:34:47,240
RESOURCES FROM THE REGENERATIVE

5675
03:34:47,240 --> 03:34:49,240
MEDICINE SONOR CONSORTIUM SO IT

5676
03:34:49,240 --> 03:34:50,440
IS THIS WHEN YOU FIT PIECES

5677
03:34:50,440 --> 03:34:52,440
TOGETHER I THINK REALLY

5678
03:34:52,440 --> 03:34:54,680
EVERYTHING IS THERE TO HELP A

5679
03:34:54,680 --> 03:34:56,880
MAKE LESS A BLACK BOX AND MORE

5680
03:34:56,880 --> 03:34:58,680
WELL DEFINED.

5681
03:34:58,680 --> 03:35:00,400
EXACTLY WHAT THE MECHANISM

5682
03:35:00,400 --> 03:35:03,600
ACTION IS FOR THESE EXOSOMAL

5683
03:35:03,600 --> 03:35:05,840
THERAPIES SO WE UNDERSTAND

5684
03:35:05,840 --> 03:35:07,840
EXACTLY WHAT IS TAKING PLACE AND

5685
03:35:07,840 --> 03:35:10,960
WHAT IS DERIVING THE THERAPEUTIC

5686
03:35:10,960 --> 03:35:14,520
EFFECTS.

5687
03:35:14,520 --> 03:35:17,360
>> IF YOU MAKE SURE THE ACTIVITY

5688
03:35:17,360 --> 03:35:20,800
IS NOT ONLY LOOKING AT CLINICAL

5689
03:35:20,800 --> 03:35:23,400
EFFICACY BUT ALSO BUILT IN

5690
03:35:23,400 --> 03:35:27,160
SPECIFIC AIMS TOWARD TO BUY

5691
03:35:27,160 --> 03:35:30,480
GENERATING EFFICACY SIGNALS ALSO

5692
03:35:30,480 --> 03:35:33,600
ALLOWING TO UNDERSTAND WHICH

5693
03:35:33,600 --> 03:35:34,840
MOLECULAR COMPONENT EFFICACY IS

5694
03:35:34,840 --> 03:35:35,760
TARGETING TO.

5695
03:35:35,760 --> 03:35:41,440
THAT IS MY MAIN COMMENT.

5696
03:35:41,440 --> 03:35:42,280
>> GREAT COMMENT.

5697
03:35:42,280 --> 03:35:43,480
THANK YOU.

5698
03:35:43,480 --> 03:35:43,600
SO

5699
03:35:43,600 --> 03:35:44,960
>> SO WE WILL OPEN FOR

5700
03:35:44,960 --> 03:35:45,560
DISCUSSION.

5701
03:35:45,560 --> 03:35:52,600
I SEE MARSHALL AND RAGESH.

5702
03:35:52,600 --> 03:35:54,880
>> ONE OF MY COLLEAGUES IS DOING

5703
03:35:54,880 --> 03:35:55,520
WORK IN THIS.

5704
03:35:55,520 --> 03:35:57,560
WHAT IS IT ACTUALLY DOING?

5705
03:35:57,560 --> 03:36:01,680
IT GETS HAND WAVING QUICKLY.

5706
03:36:01,680 --> 03:36:05,760
WHAT ARE THE COMPONENTS HAVING

5707
03:36:05,760 --> 03:36:06,200
THERAPEUTIC EFFECT?

5708
03:36:06,200 --> 03:36:07,000
WE DON'T KNOW.

5709
03:36:07,000 --> 03:36:08,680
THERE'S SOMETHING THERE AND

5710
03:36:08,680 --> 03:36:10,680
THINGS LIKE THAT ONE THING I

5711
03:36:10,680 --> 03:36:12,080
MIGHT SUGGEST ANYWAY, IS THINK

5712
03:36:12,080 --> 03:36:16,920
ABOUT PARTNERING WITH ANOTHER

5713
03:36:16,920 --> 03:36:18,440
INSTITUTE WHETHER NSF OR

5714
03:36:18,440 --> 03:36:20,120
SOMEBODY ELSE, WHO THE DO THE

5715
03:36:20,120 --> 03:36:21,280
BASIC SCIENCE ON THIS.

5716
03:36:21,280 --> 03:36:26,800
YOU WILL HAVE WELL CHARACTERIZED

5717
03:36:26,800 --> 03:36:28,280
EXOSOMES FROM WELL CHARACTERIZED

5718
03:36:28,280 --> 03:36:29,440
STEM CELLS, THAT DOESN'T MEAN

5719
03:36:29,440 --> 03:36:35,760
YOU KNOW WHAT IS IN THEM.

5720
03:36:35,760 --> 03:36:37,480
AND WHICH HAVING BIOACTIVE

5721
03:36:37,480 --> 03:36:42,000
PROPERTIES.

5722
03:36:42,000 --> 03:36:44,320
SO WHEN WE WERE DOING PEOPLE

5723
03:36:44,320 --> 03:36:48,080
TRANSPLANTS, TAKING ONE TO THE

5724
03:36:48,080 --> 03:36:50,080
OTHER PATIENTS WERE SEEING

5725
03:36:50,080 --> 03:36:51,080
IMPROVEMENT, I DIDN'T DO THOSE

5726
03:36:51,080 --> 03:36:51,840
IN GENETICS.

5727
03:36:51,840 --> 03:36:54,160
WHEN YOU ASKED WHAT IT WAS

5728
03:36:54,160 --> 03:36:56,920
TRANSPLANTED NO ONE KNEW WHAT IT

5729
03:36:56,920 --> 03:36:57,680
WAS.

5730
03:36:57,680 --> 03:37:00,400
YOU ARE IN A MUCH BETTER

5731
03:37:00,400 --> 03:37:02,600
POSITION BUTTONLY RECOMMEND

5732
03:37:02,600 --> 03:37:04,880
PARTNERSHIP WITH TO GET A GOOD

5733
03:37:04,880 --> 03:37:07,480
ABASIC SCIENCE COMPONENT OF

5734
03:37:07,480 --> 03:37:15,440
THIS.

5735
03:37:15,440 --> 03:37:18,560
>> SO PEOPLE DON'T THINK I WOKE

5736
03:37:18,560 --> 03:37:19,800
UP ON THE WRONG SIDE OF THE BED,

5737
03:37:19,800 --> 03:37:20,560
I DO LIKE THIS PROPOSAL AND

5738
03:37:20,560 --> 03:37:26,640
WANTED TO SAY SO.

5739
03:37:26,640 --> 03:37:29,040
>> THANK YOU, RAJESH.

5740
03:37:29,040 --> 03:37:32,560
I CAN JUMP IN, I THINK THAT THE

5741
03:37:32,560 --> 03:37:33,920
ISOLATION TOOLS OF EXTRA

5742
03:37:33,920 --> 03:37:35,200
CELLULAR RNA COMMUNICATION

5743
03:37:35,200 --> 03:37:37,880
PROGRAM HAS DEVELOPED AS WELL AS

5744
03:37:37,880 --> 03:37:39,480
THE ANALYTICAL TOOLS.

5745
03:37:39,480 --> 03:37:41,000
I THINK ARE REALLY GOING TO BE

5746
03:37:41,000 --> 03:37:44,680
ABLE TO ADDRESS A LOT OF THE

5747
03:37:44,680 --> 03:37:48,200
BASIC CONCERNS ABOUT MECHANISM

5748
03:37:48,200 --> 03:37:50,080
OF ACTION BECAUSE HISTORICALLY

5749
03:37:50,080 --> 03:37:52,240
HE IS SMALL VESICALES ARE

5750
03:37:52,240 --> 03:37:53,200
DIFFICULT TO PURIFY.

5751
03:37:53,200 --> 03:37:56,720
BUT SOME OF THESE TECHNOLOGIES A

5752
03:37:56,720 --> 03:37:59,960
LOT ARE MICROFLUIDIC BASED OR --

5753
03:37:59,960 --> 03:38:01,680
THERE'S A LOT OF DIFFERENT

5754
03:38:01,680 --> 03:38:04,480
TECHNOLOGIES BUILT THROUGH THIS

5755
03:38:04,480 --> 03:38:06,080
PROGRAM.

5756
03:38:06,080 --> 03:38:09,400
THEN USING THESE TOOLS WILL HAVE

5757
03:38:09,400 --> 03:38:11,440
MUCH MORE HOMOGENOUS PRODUCTION

5758
03:38:11,440 --> 03:38:14,440
OF THESE EXOSOMES THAT ARE MORE

5759
03:38:14,440 --> 03:38:15,360
WELL CHARACTERIZED.

5760
03:38:15,360 --> 03:38:18,240
SO I THINK THAT WILL GO A LONG

5761
03:38:18,240 --> 03:38:21,680
WAY INTO REALLY ANSWERING A LOT

5762
03:38:21,680 --> 03:38:23,120
OF THOSE QUESTIONS MANY TERMS OF

5763
03:38:23,120 --> 03:38:28,080
MECHANISM OF ACTION AND WHAT IS

5764
03:38:28,080 --> 03:38:33,920
REALLY RESULTING THIS IN

5765
03:38:33,920 --> 03:38:34,400
THERAPEUTIC EFFECT.

5766
03:38:34,400 --> 03:38:36,720
>> YOU WILL HAVE A PURE SOURCE

5767
03:38:36,720 --> 03:38:38,960
DEEP DIVING EVERYTHING -- EVEN

5768
03:38:38,960 --> 03:38:40,400
IF SMALL MOLECULES, DOESN'T HAVE

5769
03:38:40,400 --> 03:38:44,680
TO BE BIOLOGIC.

5770
03:38:44,680 --> 03:38:46,240
GOD KNOWS WHAT IS IN THESE

5771
03:38:46,240 --> 03:38:46,480
THINGS.

5772
03:38:46,480 --> 03:38:48,080
>> EXACTLY.

5773
03:38:48,080 --> 03:38:49,120
ANALYTICAL TOOLS THAT GO WITH

5774
03:38:49,120 --> 03:38:50,840
THESE ISOLATION TECHNOLOGIES,

5775
03:38:50,840 --> 03:38:54,000
SHOULD REALLY ALLOW US TO

5776
03:38:54,000 --> 03:38:57,120
PINPOINT THE EXACT CARGO

5777
03:38:57,120 --> 03:38:58,000
RESPONSIBLE FOR THESE

5778
03:38:58,000 --> 03:38:58,800
ACTIVITIES.

5779
03:38:58,800 --> 03:39:03,000
SO I'M CONFIDENT THAT THE NEW

5780
03:39:03,000 --> 03:39:05,560
TECHNOLOGIES WHICH I KNOW ARE

5781
03:39:05,560 --> 03:39:07,120
LOT OF THESE TECHNOLOGIES ARE

5782
03:39:07,120 --> 03:39:10,240
JUST GETTING TO THE POINT WHERE

5783
03:39:10,240 --> 03:39:13,680
BEING PUBLISHED, BUT I THINK

5784
03:39:13,680 --> 03:39:16,360
THEY ARE GOING TO BE A VERY

5785
03:39:16,360 --> 03:39:19,560
HELPFUL IN TERMS OF MAKING THESE

5786
03:39:19,560 --> 03:39:20,880
-- EXOSOMES USEFUL IN TERMS OF

5787
03:39:20,880 --> 03:39:22,080
THERAPEUTICS.

5788
03:39:22,080 --> 03:39:24,240
>> STEVE WHAT IS CHANGING IS

5789
03:39:24,240 --> 03:39:25,960
THAT WE NOW ARE LEARNING ZIP

5790
03:39:25,960 --> 03:39:28,680
CODES WHERE THEY ARE HEADED.

5791
03:39:28,680 --> 03:39:30,520
AND WHERE WHAT IS DIFFERENT FROM

5792
03:39:30,520 --> 03:39:32,800
THREE FOUR YEARS AGO WHERE THE

5793
03:39:32,800 --> 03:39:34,920
EXOSOMAL RNA CONSORTIUM HAD TO

5794
03:39:34,920 --> 03:39:37,280
BROADEN THE -- CONCERNING THAT,

5795
03:39:37,280 --> 03:39:37,880
THAT'S THE OPPORTUNITY YOU

5796
03:39:37,880 --> 03:39:39,720
SHOULDN'T MISS.

5797
03:39:39,720 --> 03:39:42,120
SO THAT COUPLE THAT IN DIFFERENT

5798
03:39:42,120 --> 03:39:45,960
WAYS YOU CAN CAPTURE SIMILAR

5799
03:39:45,960 --> 03:39:48,400
COMPONENTS SIMULATING RNAs IF

5800
03:39:48,400 --> 03:39:49,920
YOURY ARE ASSOCIATING WITH

5801
03:39:49,920 --> 03:39:51,680
INVASIVE -- TO GET THESE IN YOU

5802
03:39:51,680 --> 03:39:53,160
CAN CAPTURE THE CELLS IN THE

5803
03:39:53,160 --> 03:39:54,840
NEIGHBORHOOD, YOU ARE EXPOSING

5804
03:39:54,840 --> 03:39:57,880
TO YOUR EXOSOMES SO CAN

5805
03:39:57,880 --> 03:39:59,200
UNDERSTAND DRUG AND OBVIOUSLY

5806
03:39:59,200 --> 03:40:01,920
THERE IS A TIME ON CHIP AND N

5807
03:40:01,920 --> 03:40:04,680
CATS BEAUTIFUL PLATFORM YOU CAN

5808
03:40:04,680 --> 03:40:08,280
HAVE EXVIVO STUDIES TO SEE IF

5809
03:40:08,280 --> 03:40:13,000
YOU BUILD THESE PROCESSES UP IN

5810
03:40:13,000 --> 03:40:15,480
HUMANS IN VIVO STUDIES YOU CAN

5811
03:40:15,480 --> 03:40:16,840
FOLLOW-UP MECHANISTICALLY AS

5812
03:40:16,840 --> 03:40:19,600
WELL SO VERY NEATLY CROSS

5813
03:40:19,600 --> 03:40:21,280
FERTILIZATION IN MANY ONGOING N

5814
03:40:21,280 --> 03:40:27,720
CATS AND COMMON FUND ACTIVITIES.

5815
03:40:27,720 --> 03:40:31,000
>> I WANT TO MAKE ONE MORE

5816
03:40:31,000 --> 03:40:32,640
SUBSTANTIVE COMMENT BECAUSE OF

5817
03:40:32,640 --> 03:40:33,640
SOMETHING SAID SINCE KEN TO

5818
03:40:33,640 --> 03:40:34,760
MINE, WHICH IS WE ARE LOOKING

5819
03:40:34,760 --> 03:40:36,640
FOR PURIFIED SOURCES TO DO

5820
03:40:36,640 --> 03:40:38,080
BIOLOGY, ONE OF THE COOL THINGS

5821
03:40:38,080 --> 03:40:39,440
I HEARD MORE RESEASON WILL I IN

5822
03:40:39,440 --> 03:40:40,880
THIS ARENA IS THINKING ABOUT

5823
03:40:40,880 --> 03:40:42,880
EXOSOMES IN THE CONTEXT OF GUT

5824
03:40:42,880 --> 03:40:45,080
BRAIN ACCESS.

5825
03:40:45,080 --> 03:40:48,160
SO THE POSSIBILITY THAT THE

5826
03:40:48,160 --> 03:40:52,200
EXOSOMES MIGHT BE DERIVED FROM

5827
03:40:52,200 --> 03:40:53,840
PARTICULAR BACTERIAL STRAIN IN

5828
03:40:53,840 --> 03:40:55,520
YOUR GUT BUT HAS MEANINGFUL

5829
03:40:55,520 --> 03:40:58,920
EFFECT IN THE NERVOUS SYSTEM

5830
03:40:58,920 --> 03:41:02,760
MIGHT BE OUTLANDISH TO BELIEVE,

5831
03:41:02,760 --> 03:41:04,920
ALLOWS YOU A TESTABLE HYPOTHESIS

5832
03:41:04,920 --> 03:41:06,920
BECAUSE IT GIVES YOU A SOURCE OF

5833
03:41:06,920 --> 03:41:09,480
EXOSOMES THAT YOU CAN ACTUALLY

5834
03:41:09,480 --> 03:41:13,800
THEN PERHAPS MAKE IN LARGE

5835
03:41:13,800 --> 03:41:15,240
CULTURES PURIFY, IDENTIFY, MIX

5836
03:41:15,240 --> 03:41:17,480
AND MATCH, DO THOSE THINGS THAT

5837
03:41:17,480 --> 03:41:19,560
MIGHT GIVE YOU MORE TRACTION

5838
03:41:19,560 --> 03:41:22,320
INTO WHAT THE UNDERLYING

5839
03:41:22,320 --> 03:41:23,320
MECHANISM MIGHT BE FOR

5840
03:41:23,320 --> 03:41:31,400
THERAPEUTICS ATTENTION.

5841
03:41:31,400 --> 03:41:33,080
>> THE MAIN AREAS FOR

5842
03:41:33,080 --> 03:41:34,880
THERAPEUTIC APPLICATIONS RIGHTS

5843
03:41:34,880 --> 03:41:38,080
NOW ARE HEART LUNG KIDNEYS

5844
03:41:38,080 --> 03:41:40,120
NEURODEGENERATIVE DISORDERS, AND

5845
03:41:40,120 --> 03:41:42,120
EVEN SUCH THING WOUND HEALING

5846
03:41:42,120 --> 03:41:44,240
AND CANCER SO THOSE ARE THE MAIN

5847
03:41:44,240 --> 03:41:46,240
CURRENT APPLICATIONS THE LOW

5848
03:41:46,240 --> 03:41:48,120
HANGING FRUIT BUT THERE IS

5849
03:41:48,120 --> 03:41:50,240
TREMENDOUS AMOUNT OF

5850
03:41:50,240 --> 03:41:57,600
OPPORTUNITIES IN THIS AREA TO

5851
03:41:57,600 --> 03:42:02,080
SEE WHAT THIS THERAPEUTICS TO

5852
03:42:02,080 --> 03:42:02,680
DO.

5853
03:42:02,680 --> 03:42:08,320
AND THE SYNERGISM WITH CHIP,

5854
03:42:08,320 --> 03:42:10,640
WITH THAT WE CAN EVALUATE THAT

5855
03:42:10,640 --> 03:42:12,320
THERAPEUTIC POTENTIAL AND BREAK

5856
03:42:12,320 --> 03:42:19,080
THINGS DOWN A LITTLE BIT MORE.

5857
03:42:19,080 --> 03:42:21,480
THERE IS SYNERGY BEAN THOSE TWO

5858
03:42:21,480 --> 03:42:23,080
PROGRAMS AS WELL THAT MAKES

5859
03:42:23,080 --> 03:42:24,240
EXCITING.

5860
03:42:24,240 --> 03:42:26,880
THE TISSUE CHIP PROGRAM DOES

5861
03:42:26,880 --> 03:42:28,960
HAVE BLOOD BRAIN BARRIER CHIP SO

5862
03:42:28,960 --> 03:42:31,600
THAT WOULD BE A WAY TO LOOK AT

5863
03:42:31,600 --> 03:42:36,520
THAT AND ASSESS THAT.

5864
03:42:36,520 --> 03:42:38,600
>> THANK YOU SO MUCH CHRISTINE.

5865
03:42:38,600 --> 03:42:40,800
I BELIEVE I WILL TURN TO ANNA

5866
03:42:40,800 --> 03:42:42,480
NOW AS WE GET CLOSE TIME HERE.

5867
03:42:42,480 --> 03:42:46,080
NEED TO TAKE A VOTE.

5868
03:42:46,080 --> 03:42:47,560
I REMEMBERED.

5869
03:42:47,560 --> 03:42:49,480
THROW IT OVER TO YOU.

5870
03:42:49,480 --> 03:42:52,480
>> THANK YOU.

5871
03:42:52,480 --> 03:42:54,440
HEARING NO FURTHER DISCUSSION, I

5872
03:42:54,440 --> 03:42:56,080
WOULD LICK TO ASK YOUR APPROVAL

5873
03:42:56,080 --> 03:42:58,560
FOR THIS CONCEPT, DO I HAVE A

5874
03:42:58,560 --> 03:42:59,240
NOMINATION?

5875
03:42:59,240 --> 03:43:00,760
>> MOVED.

5876
03:43:00,760 --> 03:43:02,760
>> SECOND.

5877
03:43:02,760 --> 03:43:04,320
>> SECOND?

5878
03:43:04,320 --> 03:43:06,040
>> SECOND.

5879
03:43:06,040 --> 03:43:07,920
>> ALL IN FAVOR?

5880
03:43:07,920 --> 03:43:08,720
>> AYE.

5881
03:43:08,720 --> 03:43:09,120
AYE.

5882
03:43:09,120 --> 03:43:09,960
AYE.

5883
03:43:09,960 --> 03:43:10,320
AYE.

5884
03:43:10,320 --> 03:43:15,280
>> ANY OPPOSED?

5885
03:43:15,280 --> 03:43:19,760
ANY ABSTENTIONS?

5886
03:43:19,760 --> 03:43:21,440
WITH THAT THE SECOND CONCEPT OF

5887
03:43:21,440 --> 03:43:22,480
THE DAY IS APPROVED.

5888
03:43:22,480 --> 03:43:22,960
THANK YOU VERY MUCH.

5889
03:43:22,960 --> 03:43:26,760
BACK TO YOU, JONI.

5890
03:43:26,760 --> 03:43:28,360
>> THANK YOU SO MUCH ANNA AND

5891
03:43:28,360 --> 03:43:29,240
REST OF THE TEAM FOR THE

5892
03:43:29,240 --> 03:43:29,880
PRESENTATIONS TODAY.

5893
03:43:29,880 --> 03:43:31,720
I THINK THIS IS THE MOMENT WE

5894
03:43:31,720 --> 03:43:34,080
JUST WRAP UP OUR FIRST DAY HERE.

5895
03:43:34,080 --> 03:43:37,000
AND I WANT TO INVITE YOU TO

5896
03:43:37,000 --> 03:43:38,080
PROVIDE ANY COMMENTS OR

5897
03:43:38,080 --> 03:43:40,920
QUESTIONS HERE BEFORE WE CLOSE

5898
03:43:40,920 --> 03:43:42,120
OUT TODAY.

5899
03:43:42,120 --> 03:43:45,040
JUST QUICKLY MAKE SURE I'M NOT

5900
03:43:45,040 --> 03:43:45,720
SEEING ANY.

5901
03:43:45,720 --> 03:43:47,880
ANY LAST MINUTE QUESTIONS PLEASE

5902
03:43:47,880 --> 03:43:52,520
RAISE YOUR HAND.

5903
03:43:52,520 --> 03:43:55,760
IN THAT CASE WE WILL RECONVENE

5904
03:43:55,760 --> 03:43:57,560
TOMORROW AFTERNOON AT 1 P.M.

5905
03:43:57,560 --> 03:43:58,840
EASTERN AND I LOOK FORWARD THE

5906
03:43:58,840 --> 03:44:00,600
SEEING YOU BACK THEN.

5907
03:44:00,600 --> 03:44:02,600
I DON'T NEED THE GAVEL OUT NOW

5908
03:44:02,600 --> 03:44:04,280
BECAUSE WE ARE STILL IN OPEN

5909
03:44:04,280 --> 03:44:06,560
SESSION UNTIL TOMORROW AFTER 5.

5910
03:44:06,560 --> 03:44:08,680
STAY TUNED WE WILL SEE YOU

5911
03:44:08,680 --> 03:44:09,600
TOMORROW, THANK YOU FOR YOUR

5912
03:44:09,600 --> 00:00:00,000
ATTENTION AN ENGAGEMENT TODAY.