1
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>>THE WHOLE PREMISE OF THE 

2
00:00:08,160 --> 00:00:10,720
MEETING IS HOW CAN WE EDUCATE

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PEOPLE TO DO TRANSLATIONAL

4
00:00:12,920 --> 00:00:13,800
RESEARCH BETTER, ACTUALLY

5
00:00:13,800 --> 00:00:15,960
EXPERIENCE FIRST HAND A VARIETY

6
00:00:15,960 --> 00:00:17,360
OF SCENARIOS, FOR INVESTIGATORS,

7
00:00:17,360 --> 00:00:20,640
EVERYTHING FROM THE FACT THAT

8
00:00:20,640 --> 00:00:21,800
THEY LOSE POTENTIAL FOR

9
00:00:21,800 --> 00:00:22,520
COMMERCIALIZATION BECAUSE THEY

10
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DON'T UNDERSTAND THE PROCESS OF

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EPITHELIAL LECTUAL PROPERTY AND

12
00:00:27,000 --> 00:00:30,560
HOW THAT NEEDS TO PROCEED TO

13
00:00:30,560 --> 00:00:31,440
JUNIOR INVESTIGATORS WORKING ON

14
00:00:31,440 --> 00:00:33,240
SOMETHING FOR A LONG PERIOD OF

15
00:00:33,240 --> 00:00:34,880
TIME THAT HAS REALLY NO CLINICAL

16
00:00:34,880 --> 00:00:35,160
RELEVANCE.

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SO I THOUGHT WE WOULD START OFF

18
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WITH SUMMARIZING, ROSE CAN

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BEGIN, WITH THE PREVIOUS SORT OF

20
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UPDATES FROM THIS PARTICULAR

21
00:00:46,520 --> 00:00:46,920
WORKING GROUP.

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00:00:46,920 --> 00:00:48,840
ROSE, I WILL TURN IT OVER TO YOU

23
00:00:48,840 --> 00:00:51,760
SO THAT YOU CAN COMMENT ON THE

24
00:00:51,760 --> 00:00:52,720
CELLULAR THERAPIES FOR SOLID

25
00:00:52,720 --> 00:00:57,320
TUMORS AS FAR AS THE UPCOMING

26
00:00:57,320 --> 00:01:00,400
RFAs THAT RESULTED FROM THIS

27
00:01:00,400 --> 00:01:01,560
INITIATIVE PREVIOUSLY.

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00:01:01,560 --> 00:01:03,720
ROSE, DID YOU WANT TO TAKE OVER?

29
00:01:03,720 --> 00:01:05,240
>> I WILL BE HAPPY TO DO
THAT,

30
00:01:05,240 --> 00:01:07,040
AND I ALSO WANT TO--I DON'T KNOW

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IF WE HAVE NEW MEMBERS TO THE

32
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SUBCOMMITTEE AND I JUST WANT TO

33
00:01:12,280 --> 00:01:17,320
SAY I'M ROSE AURIgE MMA,

34
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WELCOME TO ANY NEW MEMBERS, I

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WASN'T SURE IF THEY WANTED TO

36
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INTRODUCE THEMSELVES OR NOT.

37
00:01:23,760 --> 00:01:26,920
I THINK WE HAD 2 NEW MEMBERS.

38
00:01:26,920 --> 00:01:30,960
ARE THERE ANY NEW 1S PRESENT?

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NO?

40
00:01:31,240 --> 00:01:33,400
OKAY, THEN WE CAN GO RIGHT ON.

41
00:01:33,400 --> 00:01:35,040
THE RETURN OF MEMBERS.

42
00:01:35,040 --> 00:01:37,240
>> --I THINK I'M NEW TO
THE

43
00:01:37,240 --> 00:01:37,560
SUBCOMMITTEE.

44
00:01:37,560 --> 00:01:37,920
>> I'M SORRY,.

45
00:01:37,920 --> 00:01:40,600
>> TOOK ME A MACHINEUTE TO

46
00:01:40,600 --> 00:01:41,600
UNMUTE, THANK YOU.

47
00:01:41,600 --> 00:01:43,200
>> I'M SORRY COULD YOU

48
00:01:43,200 --> 00:01:45,880
REINTRODUCE YOURSELF?

49
00:01:45,880 --> 00:01:48,400
>> SURE, I'M MILO ASSAD, 1
OF

50
00:01:48,400 --> 00:01:51,120
THE NCAB MEMBERS AND I'M FROM

51
00:01:51,120 --> 00:01:52,640
JOHNS HOPKINS.

52
00:01:52,640 --> 00:01:52,960
>> TERRIFIC.

53
00:01:52,960 --> 00:01:53,840
THANK YOU.

54
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ANYBODY ELSE? 

55
00:01:57,960 --> 00:01:59,080
IS THAT IT?

56
00:01:59,080 --> 00:01:59,680
OKAY, GREAT.

57
00:01:59,680 --> 00:02:00,600
WELL THE RETURNING MEMBERS ARE

58
00:02:00,600 --> 00:02:02,720
FAMILIAR WITH THIS TOPIC BECAUSE

59
00:02:02,720 --> 00:02:04,800
THE SUBCOMMITTEE CHOSE IT 2

60
00:02:04,800 --> 00:02:09,880
YEARS AGO AT OUR INAUGURAL OR

61
00:02:09,880 --> 00:02:11,640
REINAUGURAL I GUESS CONVENING OF

62
00:02:11,640 --> 00:02:15,400
THE SUBCOMMITTEE, SO IN THAT

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00:02:15,400 --> 00:02:18,160
TIME, WE HELD SOME--A WORKSHOP

64
00:02:18,160 --> 00:02:20,120
IN DECEMBER OF 2020.

65
00:02:20,120 --> 00:02:22,960
WE PUBLISHED A WHITE PAPER ON

66
00:02:22,960 --> 00:02:26,200
THE SUMMARY OF WHAT WE FOUND

67
00:02:26,200 --> 00:02:27,800
FROM OUR STAKEHOLDERS TO BE

68
00:02:27,800 --> 00:02:33,600
CHALLENGES FOR THE CELL THERAPY

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00:02:33,600 --> 00:02:36,240
COMMUNITY. 

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00:02:36,240 --> 00:02:36,840
HELLO?

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00:02:36,840 --> 00:02:37,120
HELLO?

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00:02:37,120 --> 00:02:41,680
I 

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00:02:41,680 --> 00:02:43,320
>> ROSE, I THINK IT'S

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BACKGROUND.

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00:02:43,880 --> 00:02:45,040
>> OH, OKAY, GREAT.

76
00:02:45,040 --> 00:02:46,680
NEXT SLIDE, PLEASE.

77
00:02:46,680 --> 00:02:48,880
AND THEN NCI EMBARKED ON A

78
00:02:48,880 --> 00:02:52,280
NUMBER OF WAYS TO HELP THE CELL

79
00:02:52,280 --> 00:02:53,440
THERAPY COMMUNITY ESPECIALLY TO

80
00:02:53,440 --> 00:02:55,200
ADVANCE NEW TREATMENTS FOR SOLID

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00:02:55,200 --> 00:02:55,680
TUMORS.

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00:02:55,680 --> 00:02:57,800
SO THESE WERE THE OUTCOMES OF

83
00:02:57,800 --> 00:03:00,960
THOSE MEETINGS, THE AREAS OF

84
00:03:00,960 --> 00:03:02,600
UNMET NEED WERE TO HAVE MORE

85
00:03:02,600 --> 00:03:04,240
SUPPORT FOR PRECLINICAL AND

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00:03:04,240 --> 00:03:05,560
TRANSLATIONAL RESEARCH, TO BE

87
00:03:05,560 --> 00:03:07,600
ABLE TO CONDUCT SMALL PROOF OF

88
00:03:07,600 --> 00:03:10,400
CONSEPTD STUDIES, BECAUSE ANIMAL

89
00:03:10,400 --> 00:03:12,600
STUDIES ARE NOT REALLY FEASIBLE

90
00:03:12,600 --> 00:03:15,440
FOR CELL THERAPIES, TO ENHANCE

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00:03:15,440 --> 00:03:16,760
CELL MANUFACTURING TECHNOLOGIES,

92
00:03:16,760 --> 00:03:21,040
RIGHT NOW, THEY ARE VERY

93
00:03:21,040 --> 00:03:23,680
CUMBERSOME AND THERE'S HIGHER

94
00:03:23,680 --> 00:03:26,000
THAN ACCEPTABLE FAILURE RATE FOR

95
00:03:26,000 --> 00:03:27,480
MAKING INDIVIDUALIZED CELL

96
00:03:27,480 --> 00:03:28,280
THERAPIES.

97
00:03:28,280 --> 00:03:30,160
WE NEED MORE BIOMARKERS SO THAT

98
00:03:30,160 --> 00:03:31,640
WE CAN UNDERSTAND HOW THE

99
00:03:31,640 --> 00:03:32,920
THERAPIES ARE WORKING AND WHAT

100
00:03:32,920 --> 00:03:34,720
PATIENTS THEY WOULD BENEFIT AND

101
00:03:34,720 --> 00:03:36,160
WE NEED BETTER IMAGING

102
00:03:36,160 --> 00:03:37,880
TECHNIQUES IN ORDER TO TRACK THE

103
00:03:37,880 --> 00:03:39,360
CELL THERAPIES AS WELL AS

104
00:03:39,360 --> 00:03:41,520
UNDERSTAND WHETHER THEY'RE

105
00:03:41,520 --> 00:03:41,800
WORKING.

106
00:03:41,800 --> 00:03:46,120
SO, I JUST WANT TO GET ON TO

107
00:03:46,120 --> 00:03:48,760
WHAT NCI HAS ADDED MOST RECENTLY

108
00:03:48,760 --> 00:03:50,880
BECAUSE I HAD ALREADY PRECEPTED

109
00:03:50,880 --> 00:03:52,680
TO YOU INFORMATION ABOUT HOW WE

110
00:03:52,680 --> 00:03:54,320
HAD EXPANDED OUR MANUFACTURING

111
00:03:54,320 --> 00:03:58,080
SERVICES UP AT OUR FREDERICK

112
00:03:58,080 --> 00:03:59,520
FACILITY, THE BIOPHARMACEUTICAL

113
00:03:59,520 --> 00:04:00,720
DEVELOPMENT PROGRAMS FACILITY

114
00:04:00,720 --> 00:04:02,080
WHERE THEY'RE MANUFACTURING CELL

115
00:04:02,080 --> 00:04:04,840
THERAPIES RIGHT NOW TO SUPPORT 2

116
00:04:04,840 --> 00:04:05,400
DIFFERENT CLINICAL STUDIES.

117
00:04:05,400 --> 00:04:08,120
AND THEN MOST RECENTLY, JUST IN

118
00:04:08,120 --> 00:04:12,160
THE LAST WEEK, WE HAVE

119
00:04:12,160 --> 00:04:15,200
PUBLISHED, 3 RFAs, TO CREATE A

120
00:04:15,200 --> 00:04:16,120
CANCER ADOPTIVE CELL THERAPY

121
00:04:16,120 --> 00:04:19,880
NETWORK OR WHAT WE'RE CALLING

122
00:04:19,880 --> 00:04:20,360
CAN-ACT.

123
00:04:20,360 --> 00:04:21,760
SO THERE IS THIS MECHANISM, IF

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00:04:21,760 --> 00:04:26,440
YOU GO TO THE NEXT SLIDE, I

125
00:04:26,440 --> 00:04:29,840
BELIEVE, THE WAY IT WORKS IS

126
00:04:29,840 --> 00:04:33,440
THESE ARE UG3, UH3 AWARDS, THE

127
00:04:33,440 --> 00:04:36,520
UG3 PHASE WILL BE THE

128
00:04:36,520 --> 00:04:38,960
PRECLINICAL AND I&  D
ENABLING

129
00:04:38,960 --> 00:04:41,040
WORK TO SUPPORT NEW CELL THERAPY

130
00:04:41,040 --> 00:04:43,240
DEVELOPMENT AND THEN THE UH3

131
00:04:43,240 --> 00:04:44,640
AWARDS WILL BE FOR OR PHASE OF

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00:04:44,640 --> 00:04:48,720
THE AWARD WILL BE TO FUND THE

133
00:04:48,720 --> 00:04:49,520
CLINICAL TRIALS.

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00:04:49,520 --> 00:04:52,600
WE INTEND THESE TO BE VERY

135
00:04:52,600 --> 00:04:54,760
COLLABORATIVE, WE WANT DIFFERENT

136
00:04:54,760 --> 00:04:56,520
CENTERS TO POOL THEIR RESOURCES

137
00:04:56,520 --> 00:04:59,120
AND COLLABORATE SO THAT WE CAN

138
00:04:59,120 --> 00:05:00,640
SUPPORT ALL OF THESE DIFFERENT

139
00:05:00,640 --> 00:05:03,480
AREAS OF NEED, THE IMAGING, THE

140
00:05:03,480 --> 00:05:05,480
BIOMARKERS, THE DEVELOPMENT OF

141
00:05:05,480 --> 00:05:07,520
NEW MANUFACTURING TECHNOLOGIES,

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00:05:07,520 --> 00:05:09,120
WHATEVER, HOPEFULLY WHEN WE

143
00:05:09,120 --> 00:05:10,360
START GETTING APPLICATIONS, WE

144
00:05:10,360 --> 00:05:12,720
WILL BE GETTING SUCH

145
00:05:12,720 --> 00:05:13,200
COLLABORATIVE EFFORTS.

146
00:05:13,200 --> 00:05:17,280
SO THERE WILL BE A TOTAL OF 7

147
00:05:17,280 --> 00:05:19,760
AWARDS RIGHT THERE IS DEPICTED

148
00:05:19,760 --> 00:05:22,000
FROM 2 ADULT AND 2 PEDIATRIC BUT

149
00:05:22,000 --> 00:05:24,160
WE DO INTEND TO HAVE THEM

150
00:05:24,160 --> 00:05:25,040
HOPEFULLY EVENLY DISTRIBUTED

151
00:05:25,040 --> 00:05:26,600
BETWEEN ADULT AND PEDIATRIC

152
00:05:26,600 --> 00:05:27,760
EFFORTS.

153
00:05:27,760 --> 00:05:32,840
AND THEN, THESE ARE GOING TO BE

154
00:05:32,840 --> 00:05:35,160
SUPPORTED BY AND IN IMMUNE CELL

155
00:05:35,160 --> 00:05:38,240
NETWORK CORE, THIS IS THE

156
00:05:38,240 --> 00:05:39,440
FREDERICK RESOURCES I MENTIONED.

157
00:05:39,440 --> 00:05:41,200
THE FREDERICK NATIONAL LAB

158
00:05:41,200 --> 00:05:46,440
RESOURCES UP IN AT THE PLANT IN

159
00:05:46,440 --> 00:05:46,920
FREDERICK.

160
00:05:46,920 --> 00:05:49,160
SO THERE IS AN INFORMATIONAL WEB

161
00:05:49,160 --> 00:05:50,280
EXPECTATIONS NEXT WEEK,

162
00:05:50,280 --> 00:05:51,360
SEPTEMBER 7th AT 4:00 P.M.,

163
00:05:51,360 --> 00:05:52,920
THE LINK IS THERE AND I CAN SEND

164
00:05:52,920 --> 00:05:54,200
IT TO YOU SEPARATELY IF YOU

165
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LIKE.

166
00:05:54,480 --> 00:05:58,280
WE ARE IN THE PROCESS OF SENDING

167
00:05:58,280 --> 00:05:59,000
E-MAIL NOTIFICATIONS OUT TO

168
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ANYONE THAT WE CAN, ALL OF THE

169
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ATTENDEES FOR OUR CELL THERAPY

170
00:06:02,600 --> 00:06:04,840
WORKSHOPS TO ALL OF OUR GRANTEES

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00:06:04,840 --> 00:06:08,040
AND OUR PORTFOLIO, TO THE CANCER

172
00:06:08,040 --> 00:06:11,320
CENTER DIRECTORS, TO THE SPORE

173
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PROGRAMS, BASICALLY ANYONE WHO

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MAY BE INTERESTED IN

175
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PARTICIPATING IN THIS EFFORT, WE

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ARE SENDING INFORMATION OUT.

177
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SO WE'RE LOOKING FORWARD TO

178
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MAKING THESE AWARDS, IN LATE

179
00:06:21,320 --> 00:06:26,560
SPRING, I GUESS BY THE JUNE NCAB

180
00:06:26,560 --> 00:06:29,080
MEETING AND GETTING THIS NETWORK

181
00:06:29,080 --> 00:06:29,400
LAUNCHED.

182
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SO THAT'S ALL I HAVE TO SAY

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ABOUT THAT AND THEN, I THINK THE

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00:06:35,880 --> 00:06:39,720
NEXT SLIDE, BELONGS TO--NEXT

185
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SLIDE.

186
00:06:40,040 --> 00:06:41,760
>> THERE WE GO, YOU ARE
UP.

187
00:06:41,760 --> 00:06:44,160
>> OKAY, SO NEXT SLIDE.

188
00:06:44,160 --> 00:06:46,280
OKAY, SO, THE TRADITIONAL MODEL

189
00:06:46,280 --> 00:06:47,680
FOR TRANSLATIONAL RESEARCH HAS

190
00:06:47,680 --> 00:06:50,760
USUALLY BEEN A HANDOFF BETWEEN

191
00:06:50,760 --> 00:06:52,840
ACADEMIC OR GOVERNMENT AND OVER

192
00:06:52,840 --> 00:06:54,320
TO INDUSTRY AND INCREASINGLY

193
00:06:54,320 --> 00:06:56,640
WHAT WE'RE SEEING IS MORE

194
00:06:56,640 --> 00:06:58,960
PARTNERSHIP MODEL ESPECIALLY THE

195
00:06:58,960 --> 00:07:01,160
LAST 10-20 YEARS, WHERE YOU CAN

196
00:07:01,160 --> 00:07:03,000
HAVE THIS INTERFACE VERY EARLY

197
00:07:03,000 --> 00:07:05,520
WITH INDUSTRY AND A PRECLINICAL

198
00:07:05,520 --> 00:07:06,240
MODELING, ET CETERA.

199
00:07:06,240 --> 00:07:07,920
SO I THINK EVERYONE ON THIS CALL

200
00:07:07,920 --> 00:07:10,760
IS PRETTY FAMILIAR WITH THE

201
00:07:10,760 --> 00:07:13,560
RESEARCH STAGING FROM

202
00:07:13,560 --> 00:07:15,080
PRECLINICAL RND THROUGH RND

203
00:07:15,080 --> 00:07:16,000
CLINICAL DATA TRIAL AND

204
00:07:16,000 --> 00:07:18,080
OBVIOUSLY THERE'S A LOT OF SORT

205
00:07:18,080 --> 00:07:19,880
OF INFORMATION AND DATA THAT

206
00:07:19,880 --> 00:07:22,760
NEEDS TO OCCUR AT EACH STEP

207
00:07:22,760 --> 00:07:23,840
ALONG THIS ACTIVITY PIPELINE, SO

208
00:07:23,840 --> 00:07:24,960
YOU KNOW YOU HAVE TARGET

209
00:07:24,960 --> 00:07:27,520
DISCOVERY WHERE YOU HAVE TO HAVE

210
00:07:27,520 --> 00:07:29,000
EXPERTISE IN SCREENING,

211
00:07:29,000 --> 00:07:29,520
STRECTURE, FREQUENCY OF

212
00:07:29,520 --> 00:07:31,480
EXPRESSION OF YOUR TARGET,

213
00:07:31,480 --> 00:07:32,560
MECHANISTIC UNDERSTANDING OF

214
00:07:32,560 --> 00:07:33,720
WHAT YOUR ACTUALLY GOING AFTER,

215
00:07:33,720 --> 00:07:35,600
THEN YOU HAVE DRUGS, SO YOU HAVE

216
00:07:35,600 --> 00:07:37,000
TEST ARTICLES THAT YOU WILL HAVE

217
00:07:37,000 --> 00:07:39,960
TO RUN THROUGH, SCREENING, LEAD

218
00:07:39,960 --> 00:07:41,200
AUTHORIZATION, YOU HAVE TO WORK

219
00:07:41,200 --> 00:07:44,360
ON DELIVERY ROUTE OF

220
00:07:44,360 --> 00:07:45,120
ADMINISTRATION, ET CETERA.

221
00:07:45,120 --> 00:07:46,680
FOR TARGETS THAT ARE LESS

222
00:07:46,680 --> 00:07:49,000
FREQUENT, YOU HAVE TO CONSIDER A

223
00:07:49,000 --> 00:07:50,160
COMPANION BIOMARKER.

224
00:07:50,160 --> 00:07:51,320
YOU ADDITIONALLY HAVE TO

225
00:07:51,320 --> 00:07:51,960
UNDERSTAND THE INDICATION THAT

226
00:07:51,960 --> 00:07:55,720
YOU WANT TO MOVE INTO ESPECIALLY

227
00:07:55,720 --> 00:07:57,000
IF THAT TARGET IS EXPRESSED IN A

228
00:07:57,000 --> 00:07:58,920
VARIETY OF DIFFERENT TYPES OF

229
00:07:58,920 --> 00:07:59,280
MALIGNANCIES.

230
00:07:59,280 --> 00:08:01,000
ONCE YOU DO HAVE A DRUG, YOU

231
00:08:01,000 --> 00:08:04,800
HAVE TO UNDERSTAND THE

232
00:08:04,800 --> 00:08:05,560
PHARMACOLOGY, METABOLISM, PK,

233
00:08:05,560 --> 00:08:07,520
TOXICOLOGY AND ALL OF THIS THEN

234
00:08:07,520 --> 00:08:11,000
NEEDS TO SEGUE INTO AN IND FOR

235
00:08:11,000 --> 00:08:12,000
EVENTUAL IMPLEMENTATION IN A

236
00:08:12,000 --> 00:08:13,920
PHASE 1 CLINICAL TRIAL INCLUDING

237
00:08:13,920 --> 00:08:17,840
THINGS LIKE SAFETY, DOSE, AND

238
00:08:17,840 --> 00:08:18,200
SIGNAL RESPONSE.

239
00:08:18,200 --> 00:08:20,480
AND CLINICAL TRIAL, YOU KNOW

240
00:08:20,480 --> 00:08:21,880
DESIGNS ARE INCREASINGLY BECOMES

241
00:08:21,880 --> 00:08:24,360
A BIT MORE COMPLEX, INCLUDING

242
00:08:24,360 --> 00:08:26,440
THINGS LIKE ADAPTIVE BASIAN

243
00:08:26,440 --> 00:08:28,680
CLINICAL TRIAL DESIGN, THE

244
00:08:28,680 --> 00:08:29,600
SEAMLESS 1-3 TRANSITIONS AND

245
00:08:29,600 --> 00:08:32,320
THEN ALSO WIND O OF OPPORTUNITY

246
00:08:32,320 --> 00:08:34,080
STUDIES THAT ARE BEING FORWARDED

247
00:08:34,080 --> 00:08:35,520
BETWEEN PHASE 1 AND 2 CLINICAL

248
00:08:35,520 --> 00:08:37,040
TRIALS TO LOOK TO SEE IF THERE'S

249
00:08:37,040 --> 00:08:39,000
ENGAGEMENT TO THE TARGET PRIOR

250
00:08:39,000 --> 00:08:40,680
TO MAKING DEFINITIVE STEPS

251
00:08:40,680 --> 00:08:42,040
TOWARDS LATER STAGE CLINICAL

252
00:08:42,040 --> 00:08:42,560
TRIALS.

253
00:08:42,560 --> 00:08:45,120
SO THIS OBVIOUSLY INCLUDES A

254
00:08:45,120 --> 00:08:45,880
LEVEL OF RIGOR.

255
00:08:45,880 --> 00:08:48,800
IT ALSO REQUIRES A VERY DIVERSE

256
00:08:48,800 --> 00:08:50,120
AREAS OF EXPERTISE IN ORDER TO

257
00:08:50,120 --> 00:08:52,640
MOVE ALONG THIS PIPELINE.

258
00:08:52,640 --> 00:08:54,160
AND I THINK WE'RE ALL VERY MUCH

259
00:08:54,160 --> 00:08:56,000
AWARE OF THE VALLEY OF DEATH

260
00:08:56,000 --> 00:08:57,800
WHERE QUITE A FEW OF THESE

261
00:08:57,800 --> 00:08:58,840
COMPOUNDS NEVER REALLY SEE THE

262
00:08:58,840 --> 00:09:02,080
LIGHT OF DAY OR THEY MAY BE

263
00:09:02,080 --> 00:09:03,880
BEGIN EARLY PHASE 1 OR 2

264
00:09:03,880 --> 00:09:05,600
CLINICAL TRIAL ONLY TO FAIL AT

265
00:09:05,600 --> 00:09:12,040
LATER STAGE CLINICAL STUDIES. 

266
00:09:12,040 --> 00:09:12,800
SO, NEXT SLIDE.

267
00:09:12,800 --> 00:09:14,000
SO, THIS COMES FROM THE FACT

268
00:09:14,000 --> 00:09:16,280
THAT IN ADDITION TO HAVING THE

269
00:09:16,280 --> 00:09:18,360
ABILITY TO DO GOOD QUALITY

270
00:09:18,360 --> 00:09:19,520
SCIENCE, THERE'S OTHER KEY

271
00:09:19,520 --> 00:09:20,800
ELEMENTS THAT A LOT OF

272
00:09:20,800 --> 00:09:23,360
INVESTIGATORS ARE NOT

273
00:09:23,360 --> 00:09:24,440
NECESSARILY FAMILIAR WITH.

274
00:09:24,440 --> 00:09:26,200
I THINK EVERYONE IS VERY MUCH

275
00:09:26,200 --> 00:09:28,480
AWARE OF THE FACT THAT THERE HAS

276
00:09:28,480 --> 00:09:30,400
BEEN ISSUES WITH REPRODUCIBILITY

277
00:09:30,400 --> 00:09:31,680
ESPECIALLY IN BASIC SCIENCE LABS

278
00:09:31,680 --> 00:09:33,240
WHEN PHARMA GETS THEIR HANDS ON

279
00:09:33,240 --> 00:09:34,280
IT, IT'S A CHALLENGE TO

280
00:09:34,280 --> 00:09:35,840
NECESSARILY BE ABLE TO REPRODUCE

281
00:09:35,840 --> 00:09:37,760
THAT DATA FOR A WIDE VARIETY OF

282
00:09:37,760 --> 00:09:38,000
REASONS.

283
00:09:38,000 --> 00:09:39,480
A LOT OF TIMES AN INVESTIGATOR

284
00:09:39,480 --> 00:09:41,240
MAY BE VERY INTERESTED IN A

285
00:09:41,240 --> 00:09:43,280
MECHANISM, BUT NOT NECESSARILY

286
00:09:43,280 --> 00:09:45,520
CONSIDERED THINGS LIKE THE

287
00:09:45,520 --> 00:09:47,240
CLINICAL RELEVANCE AND

288
00:09:47,240 --> 00:09:48,720
INDICATION, MANY TIMES

289
00:09:48,720 --> 00:09:50,440
COMPETITIVE LANDSCAPE IS NOT

290
00:09:50,440 --> 00:09:53,000
CONSIDERED SO THERE'S A LOT OF

291
00:09:53,000 --> 00:09:54,720
EFFORT EXERTED ONLY AGAIN NOT TO

292
00:09:54,720 --> 00:09:56,320
SEE LATER STAGE CLINICAL TRIAL

293
00:09:56,320 --> 00:09:56,840
DEVELOPMENT, ET CETERA.

294
00:09:56,840 --> 00:09:58,240
A LOT OF TIMES INVESTIGATORS

295
00:09:58,240 --> 00:10:00,400
DON'T THINK ABOUT THINGS LIKE

296
00:10:00,400 --> 00:10:01,400
RETURN OPEN OF INVESTMENT FOR

297
00:10:01,400 --> 00:10:03,480
EXAMPLE, IF YOU ARE DOING A

298
00:10:03,480 --> 00:10:05,600
REALLY INTENSIVE G&  P
PRODUCT

299
00:10:05,600 --> 00:10:07,240
CELLULAR THERAPEUTIC, WHERE IT

300
00:10:07,240 --> 00:10:10,080
REQUIRES A HIGH AMOUNT OF

301
00:10:10,080 --> 00:10:11,160
DOLLARS, A PHARMA COMPANY MAY

302
00:10:11,160 --> 00:10:12,320
NOT NECESSARILY BE INTERESTED IN

303
00:10:12,320 --> 00:10:13,560
MOVING THAT ALONG BECAUSE

304
00:10:13,560 --> 00:10:14,520
THEY'RE NOT ESSENTIALLY GOING TO

305
00:10:14,520 --> 00:10:17,960
GET A RETURN ON INVESTMENT FOR

306
00:10:17,960 --> 00:10:19,000
ACTUALLY IMPLEMENTING THAT IN

307
00:10:19,000 --> 00:10:22,000
LET'S SAY A RARE CANCER SITE,

308
00:10:22,000 --> 00:10:23,520
YOU KNOW INTELLECTUAL PROPERTY

309
00:10:23,520 --> 00:10:24,920
CONSIDERATIONS, YOU HAVE A WHOLE

310
00:10:24,920 --> 00:10:26,120
SLEW OF REGULATORY ISSUES, MANY

311
00:10:26,120 --> 00:10:27,320
PEOPLE ARE NOT NECESSARILY

312
00:10:27,320 --> 00:10:29,400
TRAINED IN THIS, OTHER THAN A

313
00:10:29,400 --> 00:10:30,360
CURSEARY CLINICAL TRIAL OF

314
00:10:30,360 --> 00:10:32,360
COURSE IN THEIR CANCER CENTER,

315
00:10:32,360 --> 00:10:33,640
THERE'S PRIVACY ISSUES AND

316
00:10:33,640 --> 00:10:35,200
OBVIOUSLY THERE'S ALSO FUNDING

317
00:10:35,200 --> 00:10:35,560
ALIGNMENT.

318
00:10:35,560 --> 00:10:37,280
IN OTHER WORDS HOW DO YOU

319
00:10:37,280 --> 00:10:38,480
IDENTIFY WHICH FUNDING SOURCES

320
00:10:38,480 --> 00:10:40,480
YOU MIGHT WANT TO CONSIDER ALONG

321
00:10:40,480 --> 00:10:41,360
THIS CONTINUUM.

322
00:10:41,360 --> 00:10:43,240
THIS IS OBVIOUSLY VERY

323
00:10:43,240 --> 00:10:45,360
CHALLENGING FOR TRANSLATIONAL

324
00:10:45,360 --> 00:10:46,080
RESEARCHERS AND OUR BASIC

325
00:10:46,080 --> 00:10:47,040
SCIENTISTS AND 1 OF THE THINGS

326
00:10:47,040 --> 00:10:48,760
WE'VE BEEN TRYING TO DO IS

327
00:10:48,760 --> 00:10:50,240
TRYING TO HELP GUIDE SOME OF

328
00:10:50,240 --> 00:10:51,760
THESE FOLKS THAT WANT TO DO

329
00:10:51,760 --> 00:10:54,800
THESE KINDS OF TRANSLATIONAL

330
00:10:54,800 --> 00:10:55,080
RESEARCH.

331
00:10:55,080 --> 00:10:58,960
WE'RE SORT OF A METRIC, SO 1

332
00:10:58,960 --> 00:11:00,920
THING WE DEVELOPED AT CANCER, IS

333
00:11:00,920 --> 00:11:02,280
THE PANEL I'M SHOWING ON THE

334
00:11:02,280 --> 00:11:03,080
RIGHT WHERE IT ALLOWS

335
00:11:03,080 --> 00:11:04,240
INVESTIGATORS TO START THINKING

336
00:11:04,240 --> 00:11:06,360
A LITTLE BIT ABOUT HOW AS YOU'RE

337
00:11:06,360 --> 00:11:07,520
DEVELOPING SOMETHING, A DRUG, OR

338
00:11:07,520 --> 00:11:11,720
GOING AFTER A TARGET, HOW THAT

339
00:11:11,720 --> 00:11:13,440
WOULD ACTUALLY PAN OUT IF IT

340
00:11:13,440 --> 00:11:14,560
ACTUALLY PASSED TO PHARMA MPLET

341
00:11:14,560 --> 00:11:16,120
BUT I WILL TELL YOU AS THE

342
00:11:16,120 --> 00:11:18,120
PERSON THAT'S IN CHARGE OF OUR

343
00:11:18,120 --> 00:11:18,800
TRANSLATIONAL BRIDGE PROGRAM

344
00:11:18,800 --> 00:11:21,280
HERE AT THE CANCER CENTER, THIS

345
00:11:21,280 --> 00:11:22,440
WAS REALLY--IT'S BEEN A STEEP

346
00:11:22,440 --> 00:11:23,520
LEARNING CURVE FOR MANY OF THE

347
00:11:23,520 --> 00:11:24,680
INVESTIGATORS AND IT'S BEEN A

348
00:11:24,680 --> 00:11:26,360
LITTLE PAINFUL FOR THEM ACTUALLY

349
00:11:26,360 --> 00:11:28,680
TO UNDERSTAND SOME OF THESE

350
00:11:28,680 --> 00:11:30,240
BASIC CONCEPTS.

351
00:11:30,240 --> 00:11:32,560
SO, AS A TRANSITION, AS I MOVE

352
00:11:32,560 --> 00:11:35,040
FROM 1 CANCER CENTER TO ANOTHER

353
00:11:35,040 --> 00:11:37,480
I NOTICE THE SAME ISSUES WERE

354
00:11:37,480 --> 00:11:40,120
SORT OF EMERGING BETWEEN THESE

355
00:11:40,120 --> 00:11:41,640
VARIOUS CENTERS IN, IN LITTLER

356
00:11:41,640 --> 00:11:43,400
WORDS THIS IS NOT JUST EXCLUSIVE

357
00:11:43,400 --> 00:11:44,720
TO 1 PARTICULAR CENTER, I THINK

358
00:11:44,720 --> 00:11:46,280
IT'S VERY UNIVERSAL AND THE

359
00:11:46,280 --> 00:11:48,400
QUESTION IS, THERE'S A LOT OF

360
00:11:48,400 --> 00:11:50,600
REDUNDANCY, OF SOME OF THE

361
00:11:50,600 --> 00:11:51,920
TEACHING AND SOMETIMES THERE'S

362
00:11:51,920 --> 00:11:53,920
TREMENDOUS GAPS IN THE TEACHING

363
00:11:53,920 --> 00:11:56,360
AT ANY GIVEN CANCER CENTER.

364
00:11:56,360 --> 00:11:56,760
SO NEXT SLIDE.

365
00:11:56,760 --> 00:12:00,920
SO WHAT I WANTED TO DO IS FOR

366
00:12:00,920 --> 00:12:02,320
THIS MEETING TODAY, GO BACK,

367
00:12:02,320 --> 00:12:04,600
THERE SHOULD BE A SLIDE IN

368
00:12:04,600 --> 00:12:05,160
BETWEEN.

369
00:12:05,160 --> 00:12:06,840
OKAY, I'M SORRY, GO FORWARD,

370
00:12:06,840 --> 00:12:09,800
JUST A FEW MORE SLIDES.

371
00:12:09,800 --> 00:12:15,800
SO WHAT WE WANT TO DO, GO

372
00:12:15,800 --> 00:12:16,880
FORWARD 1 MORE, 1 OF THE THINGS

373
00:12:16,880 --> 00:12:18,520
WE WANT TO DO AND I WILL TURN IT

374
00:12:18,520 --> 00:12:19,840
BACK OVER TO ROSE IN JUST A

375
00:12:19,840 --> 00:12:23,080
SECOND, IS WE WANT TO HAVE A

376
00:12:23,080 --> 00:12:27,600
DISCUSSION TODAY WITH REGARDS TO

377
00:12:27,600 --> 00:12:29,000
WHETHER THE NCI CAN SERVE AS A

378
00:12:29,000 --> 00:12:31,000
KEY HUB FOR BASIC TRANSLATION

379
00:12:31,000 --> 00:12:32,960
AND RESEARCH UTILIZING AND

380
00:12:32,960 --> 00:12:33,800
EXPLOITING ELECTRONIC FORMAT SO

381
00:12:33,800 --> 00:12:35,080
WE WANT TO TALK ABOUT WHETHER

382
00:12:35,080 --> 00:12:36,800
THERE'S POETIC TEBTIAL FOR

383
00:12:36,800 --> 00:12:38,800
ARCHIVING A LIBRARY OF TOPICS

384
00:12:38,800 --> 00:12:40,240
FOR RAPID ACCESS, WHETHER WE

385
00:12:40,240 --> 00:12:42,000
NEED TO HARMONIZE THIS KIND OF

386
00:12:42,000 --> 00:12:43,760
TRAINING, WHETHER WE COULD

387
00:12:43,760 --> 00:12:45,600
REDUCE REDUNDANCY IN DEVELOPING

388
00:12:45,600 --> 00:12:49,360
THE CURRICULUM NATIONWIDE, AND

389
00:12:49,360 --> 00:12:51,080
WHETHER WE COULD ACTUALLY FOLD

390
00:12:51,080 --> 00:12:52,280
IN INSTRUCTIONS THAT ARE KEY

391
00:12:52,280 --> 00:12:54,480
LEADERS IN THE WIELD.

392
00:12:54,480 --> 00:12:57,920
I ALSO THINK CANCER CENTERS HAVE

393
00:12:57,920 --> 00:12:59,600
A APPROXIMATE SPECIFIC EXPERTISE

394
00:12:59,600 --> 00:13:01,000
AND A CENTER WHERE A CANCER

395
00:13:01,000 --> 00:13:02,200
CENTER IS GOOD AT NANO

396
00:13:02,200 --> 00:13:04,360
TECHNOLOGY AND HAD IS A DOMAIN I

397
00:13:04,360 --> 00:13:05,280
WOULD NOMINATE OUR CANCER CENTER

398
00:13:05,280 --> 00:13:08,600
FOR AS FAR AS PROVIDING

399
00:13:08,600 --> 00:13:09,360
INSTRUCTION IN DEVELOPING

400
00:13:09,360 --> 00:13:09,920
INTELLECTUAL PROPERTY

401
00:13:09,920 --> 00:13:12,520
SPECIFICALLY IN THIS PARTICULAR

402
00:13:12,520 --> 00:13:12,760
AREA.

403
00:13:12,760 --> 00:13:15,800
I'M WONDERING IF WE CAN USE THE

404
00:13:15,800 --> 00:13:17,240
CURRENT KRIM LUMOFFERRED BY THE

405
00:13:17,240 --> 00:13:20,720
NCI AS A STARTING POINT FOR THIS

406
00:13:20,720 --> 00:13:21,560
INITIATIVE AND THIS IS PART OF

407
00:13:21,560 --> 00:13:24,120
THE REASON WHY WE ASKED

408
00:13:24,120 --> 00:13:25,520
DR. [INDISCERNIBLE] TO PROVIDE

409
00:13:25,520 --> 00:13:27,800
HIS PRESENTATION AND ROSE TO

410
00:13:27,800 --> 00:13:29,240
JUST TO SORT OF EMPHASIZE THE

411
00:13:29,240 --> 00:13:31,640
NEED FOR THIS, GO BACK 2 OR 3

412
00:13:31,640 --> 00:13:33,440
SLIDES, PLEASE?

413
00:13:33,440 --> 00:13:35,120
THERE'S TREMENDOUS DEMAND

414
00:13:35,120 --> 00:13:36,160
THROUGH THE DEVELOPMENTAL

415
00:13:36,160 --> 00:13:37,360
CONSULTATION SERVICE AND I WILL

416
00:13:37,360 --> 00:13:39,440
LET ROSE KIND OF COMMENT ON THIS

417
00:13:39,440 --> 00:13:40,720
REAR FOR THESE PARTICULAR PIECES

418
00:13:40,720 --> 00:13:42,400
OF KNOWLEDGE, SO THIS IS NOT

419
00:13:42,400 --> 00:13:43,680
JUST AT THE CANCER CENTER LEVEL,

420
00:13:43,680 --> 00:13:45,160
THIS IS AT THE NATIONAL LEVEL.

421
00:13:45,160 --> 00:13:46,560
SO ROSE, DID YOU WANT TO COMMENT

422
00:13:46,560 --> 00:13:48,560
A LITTLE BIT ABOUT THIS

423
00:13:48,560 --> 00:13:50,040
CONSULTATION SERVICE?

424
00:13:50,040 --> 00:13:51,640
>> SURE, JUST VERY
BRIEFLY.

425
00:13:51,640 --> 00:13:54,240
YOU KNOW HAVING OVERSEEN GRANTS

426
00:13:54,240 --> 00:13:57,160
PORTFOLIOS FOR ALMOST 20 YEARS,

427
00:13:57,160 --> 00:14:02,080
AND WE DO HAVE IN OUR PORTFOLIO

428
00:14:02,080 --> 00:14:05,520
OVER 800 ACTIVE AWARDS THAT ARE

429
00:14:05,520 --> 00:14:06,520
ALL INVOLVING, DISCOVERING

430
00:14:06,520 --> 00:14:07,720
DEVELOPMENT OF NEW THERAPIES.

431
00:14:07,720 --> 00:14:10,160
WE SPEND A LOT OF TIME EDUCATING

432
00:14:10,160 --> 00:14:12,000
OUR INVESTIGATORS ABOUT THE

433
00:14:12,000 --> 00:14:13,520
CRITICAL PATH TO DEVELOP--TO

434
00:14:13,520 --> 00:14:14,480
DISCOVER AND DEVELOP MOLECULES

435
00:14:14,480 --> 00:14:18,280
AND IT JUST IS A CONSTANT

436
00:14:18,280 --> 00:14:19,640
TURNING OVER IN YOU KNOW NEW

437
00:14:19,640 --> 00:14:21,200
INVESTIGATORS WHO NEED TO LEARN

438
00:14:21,200 --> 00:14:22,800
THIS INFORMATION.

439
00:14:22,800 --> 00:14:25,240
SO, WE LAUNCHED SEVERAL YEARS

440
00:14:25,240 --> 00:14:26,640
AGO, THIS PAGE, ACTUALLY IT WAS

441
00:14:26,640 --> 00:14:30,480
ALREADY AVAILABLE BUT WE JUST

442
00:14:30,480 --> 00:14:32,720
BEGAN REALLY ADVERTISING IT AT

443
00:14:32,720 --> 00:14:34,880
AACR AND ASCO AND OTHER VENUES

444
00:14:34,880 --> 00:14:35,680
AND ENCOURAGING ANY OF OUR

445
00:14:35,680 --> 00:14:37,920
INVESTIGATOR WHO IS ARE ENGAGED

446
00:14:37,920 --> 00:14:39,400
IN DISCOVERING DEVELOPMENTAL NEW

447
00:14:39,400 --> 00:14:42,040
THERAPIES TO REQUEST A

448
00:14:42,040 --> 00:14:42,760
CONSULTATION ON DEVELOPMENT AND

449
00:14:42,760 --> 00:14:46,840
IF YOU WILL GO TO THE NEXT, TO

450
00:14:46,840 --> 00:14:47,240
THE NEXT PAGE.

451
00:14:47,240 --> 00:14:50,800
SO THIS IS AVAILABLE FOR ALL

452
00:14:50,800 --> 00:14:53,440
COMERS, IT'S NOT-IT'S NOT JUST

453
00:14:53,440 --> 00:14:54,520
FOR ACADEMEITIONS, IT'S NOT JUST

454
00:14:54,520 --> 00:14:56,440
FOR THOSE WHO HAVE FUNDING, WE

455
00:14:56,440 --> 00:14:58,040
WILL TALK TO PRETTY MUCH ANYBODY

456
00:14:58,040 --> 00:15:01,720
AND IT'S A CONFIDENTIAL

457
00:15:01,720 --> 00:15:02,200
CONSULTATION.

458
00:15:02,200 --> 00:15:03,240
YOU KNOW, THEY CAN SHARE

459
00:15:03,240 --> 00:15:05,360
STRUCTURES WITH US, AND OTHER

460
00:15:05,360 --> 00:15:07,240
INFORMATION AND IT IS HELD

461
00:15:07,240 --> 00:15:10,120
CONFIDENTIAL AS ALL OF OUR GRANT

462
00:15:10,120 --> 00:15:10,400
INFORMATION.

463
00:15:10,400 --> 00:15:14,080
AND WE WILL JUST SEE A BREAK

464
00:15:14,080 --> 00:15:17,560
DOWN OF WHAT OUR USERS HAVE

465
00:15:17,560 --> 00:15:18,880
LOOKED LIKE, SO IT'S LARGELY

466
00:15:18,880 --> 00:15:21,680
ACADEMIC BUT WE DO GET QUITE A

467
00:15:21,680 --> 00:15:22,600
FEW CONSULTATIONS FROM INDUSTRY

468
00:15:22,600 --> 00:15:26,160
AND WE HAVE WORKED WITH THE

469
00:15:26,160 --> 00:15:27,800
SBIRPROGRAM BEFORE TO HAVE JOINT

470
00:15:27,800 --> 00:15:30,400
CONSULTATIONS, AND WE ALSO HAVE

471
00:15:30,400 --> 00:15:31,440
HAD CONSULTATIONS ALL AROUND THE

472
00:15:31,440 --> 00:15:33,920
COUNTRY AS WELL AS AROUND THE

473
00:15:33,920 --> 00:15:34,120
WORLD.

474
00:15:34,120 --> 00:15:35,520
IT'S A CHALLENGE SETTING UP

475
00:15:35,520 --> 00:15:37,480
THOSE CONFERENCE CALLS BUT WE

476
00:15:37,480 --> 00:15:38,240
DO, INTERNATIONALLY, AND THEN

477
00:15:38,240 --> 00:15:40,120
YOU CAN SEE THE TOPICS THAT ARE

478
00:15:40,120 --> 00:15:43,120
REQUESTED, A LOT OF IT IS JUST

479
00:15:43,120 --> 00:15:45,480
THEY PRECLINICAL, CRITICAL PATH

480
00:15:45,480 --> 00:15:46,960
ACTIVITIES THAT FOLKS ARE JUST

481
00:15:46,960 --> 00:15:48,280
NOT AWARE OF WHETHER IT'S

482
00:15:48,280 --> 00:15:50,480
COMMUNICATION WITH THE FDA, YOU

483
00:15:50,480 --> 00:15:52,000
KNOW, WHAT TYPES OF

484
00:15:52,000 --> 00:15:56,200
COMMUNICATIONS AND WHEN THEY

485
00:15:56,200 --> 00:15:57,720
SHOULD BE COMMUNICATING.

486
00:15:57,720 --> 00:15:59,200
WHAT THEIR PRECLINICAL AND

487
00:15:59,200 --> 00:16:00,000
PHARMACOLOGY AND TOXICOLOGY

488
00:16:00,000 --> 00:16:01,920
OUGHT TO LOOK LIKE FOR THE GIVEN

489
00:16:01,920 --> 00:16:03,640
KIND OF THERAPY THEY'RE

490
00:16:03,640 --> 00:16:05,160
DEVELOPING, WHAT SORTS OF TUMOR

491
00:16:05,160 --> 00:16:06,600
MODELS OR PROOF OF CONCEPT THEY

492
00:16:06,600 --> 00:16:09,040
MIGHT NEED AND THEN YOU KNOW,

493
00:16:09,040 --> 00:16:10,760
THINGS LIKE MANUFACTURING AND

494
00:16:10,760 --> 00:16:11,680
SYNTHESIS.

495
00:16:11,680 --> 00:16:13,680
SO, WE ALSO ARE ENGAGED IN THIS

496
00:16:13,680 --> 00:16:15,080
WITH OUR NANO TECHNOLOGY

497
00:16:15,080 --> 00:16:16,160
PARTNERS AND OUR DIVISION AS

498
00:16:16,160 --> 00:16:18,640
WELL AS WITH THE IMAGING FOLKS

499
00:16:18,640 --> 00:16:20,840
IN OUR DIVISION, SO WE DO GET

500
00:16:20,840 --> 00:16:23,280
REQUESTS TO TALK ABOUT IMAGING

501
00:16:23,280 --> 00:16:26,120
AGENTS THAT ARE UNDER

502
00:16:26,120 --> 00:16:27,360
DEVELOPMENT OR NANO TECHNOLOGY

503
00:16:27,360 --> 00:16:28,160
AGENTS.

504
00:16:28,160 --> 00:16:32,120
SO  THERE'S A REALLY GREAT NEED.

505
00:16:32,120 --> 00:16:33,800
THEY ARE A LITTLE SHY IN TALKING

506
00:16:33,800 --> 00:16:36,120
WITH US, BUT I THINK A LOT OF IT

507
00:16:36,120 --> 00:16:37,240
HAS TO DO WITH THE FACT THAT

508
00:16:37,240 --> 00:16:38,480
THEY DON'T KNOW WHAT THEY DON'T

509
00:16:38,480 --> 00:16:38,680
KNOW.

510
00:16:38,680 --> 00:16:40,920
SO A LOT OF TIMES THIS IS VERY

511
00:16:40,920 --> 00:16:42,040
ENLIGHTENING FOR INVESTIGATORS,

512
00:16:42,040 --> 00:16:44,080
THEY JUST DON'T--THEY MAY BE

513
00:16:44,080 --> 00:16:45,720
EXPERTS IN CHEMISTRY BUT NOT IN

514
00:16:45,720 --> 00:16:47,000
BIOLOGY, YOU KNOW THEY JUST

515
00:16:47,000 --> 00:16:48,440
DON'T HAVE THE FULL COMPLEMENT

516
00:16:48,440 --> 00:16:52,120
OF KNOWLEDGE IN ORDER TO GET

517
00:16:52,120 --> 00:16:56,800
SOMETHING THROUGH INTO IND. 

518
00:16:56,800 --> 00:17:02,360
>> SO WITH THAT, DR.
BOGLER'S

519
00:17:02,360 --> 00:17:03,240
SLIDES, PLEASE?

520
00:17:03,240 --> 00:17:04,000
>> YEAH, THANK YOU VERY
MUCH.

521
00:17:04,000 --> 00:17:05,400
I THOUGHT IT MIGHT BE HELPFUL TO

522
00:17:05,400 --> 00:17:10,480
SHARE WITH THE COMMITTEE SOME OF

523
00:17:10,480 --> 00:17:11,920
THE ACTIVITIES ALREADY EXTEND AT

524
00:17:11,920 --> 00:17:12,960
THE CENTER FOR CANCER TRAINING

525
00:17:12,960 --> 00:17:14,720
IN THIS SPACE, SO I PREPARED A

526
00:17:14,720 --> 00:17:16,720
VERY SHORT DECK THAT I'M KIND OF

527
00:17:16,720 --> 00:17:17,840
PERHAPS SETS THE LANDSCAPE OF

528
00:17:17,840 --> 00:17:19,600
THE KINDS OF THINGS THAT ARE

529
00:17:19,600 --> 00:17:23,000
ALREADY GOING ON AND THE KINDS

530
00:17:23,000 --> 00:17:24,320
OF EXISTING MECHANISMS THAT

531
00:17:24,320 --> 00:17:25,480
WOULD SUPPORT AN EFFORT LIKE

532
00:17:25,480 --> 00:17:25,880
THIS.

533
00:17:25,880 --> 00:17:28,040
SO ON THE NEXT SLIDE IS AN

534
00:17:28,040 --> 00:17:29,200
INTRAMURAL PROGRAM THAT I THINK

535
00:17:29,200 --> 00:17:31,680
MAY BE THE COMMITTEE IS NOT

536
00:17:31,680 --> 00:17:31,960
AWARE OF.

537
00:17:31,960 --> 00:17:33,240
THIS IS ACTUALLY A PARTNERSHIP

538
00:17:33,240 --> 00:17:35,800
WITH THE FDA THAT WE'VE BEEN

539
00:17:35,800 --> 00:17:38,960
DOING SINCE 2005 WITH THE GOAL

540
00:17:38,960 --> 00:17:41,480
OF BRINGING DISCOVERIES, TO THE

541
00:17:41,480 --> 00:17:43,320
CLINIC MORE QUICKLY AND IT'S A 2

542
00:17:43,320 --> 00:17:44,960
YEAR FELLOWSHIP THAT'S OFFERED

543
00:17:44,960 --> 00:17:46,600
TO PEOPLE BOTH FROM OUR

544
00:17:46,600 --> 00:17:47,240
INTRAMURAL PROGRAM, BUT YOU

545
00:17:47,240 --> 00:17:50,280
DON'T HAVE TO COME FROM THE

546
00:17:50,280 --> 00:17:50,840
NCI'S INTRAMURAL PROGRAM.

547
00:17:50,840 --> 00:17:52,880
THE IDEA IS TO STRAIN SCIENTISTS

548
00:17:52,880 --> 00:17:55,480
IN RESEARCH AND RESEARCH RELATED

549
00:17:55,480 --> 00:17:56,320
REGULATORY AREAS, POLICIES,

550
00:17:56,320 --> 00:17:57,280
REGULATIONS SO THAT THEY REALLY

551
00:17:57,280 --> 00:17:59,680
UNDERSTAND WHAT IT TAKES TO GET

552
00:17:59,680 --> 00:18:02,400
THROUGH AN FDA APPROVAL PROCESS.

553
00:18:02,400 --> 00:18:05,240
AND AS YOU CAN SEE, WE'VE HAD 70

554
00:18:05,240 --> 00:18:07,120
GRADUATES TO DATE FROM THIS

555
00:18:07,120 --> 00:18:07,480
PROGRAM.

556
00:18:07,480 --> 00:18:08,960
MANY OF THEM WORK AT FDA BUT

557
00:18:08,960 --> 00:18:10,760
SOME GO TO INDUSTRY, A HANDFUL

558
00:18:10,760 --> 00:18:13,360
GO TO GOVERNMENT AND ACADEMIA OR

559
00:18:13,360 --> 00:18:14,440
CLINICAL ROLES.

560
00:18:14,440 --> 00:18:19,200
SO, THIS IS CLEARLY A 2 YEAR

561
00:18:19,200 --> 00:18:19,720
IMMERSIVE FELLOWSHIP.

562
00:18:19,720 --> 00:18:21,680
IT'S NOT A SHORT COURSE, IT'S

563
00:18:21,680 --> 00:18:23,680
NOT SOMETHING DELIVERED

564
00:18:23,680 --> 00:18:24,200
ELECTRONICALLY, IT'S QUITE

565
00:18:24,200 --> 00:18:25,200
INTENSE BUT I WANTED TO MENTION

566
00:18:25,200 --> 00:18:27,280
IT BECAUSE I THINK IT'S AN

567
00:18:27,280 --> 00:18:28,880
IMPORTANT CONTRIBUTOR TO THIS

568
00:18:28,880 --> 00:18:29,320
ISSUE.

569
00:18:29,320 --> 00:18:32,600
THE NEXT SLIDE, THEN, SHIFTS TO

570
00:18:32,600 --> 00:18:34,320
EXTRAMURAL AND JUST REMINDS THE

571
00:18:34,320 --> 00:18:38,120
COMMITTEE OF THE OFFERINGS FROM

572
00:18:38,120 --> 00:18:39,360
IN CREATIVE DEVELOPMENT

573
00:18:39,360 --> 00:18:40,040
TRAINING, FELLOWSHIPS AND

574
00:18:40,040 --> 00:18:41,800
EDUCATION FROM THE NCI, NOT JUST

575
00:18:41,800 --> 00:18:43,000
FROM THE CENTER FOR CANCER

576
00:18:43,000 --> 00:18:45,880
TRAINING BUT ALSO FROM THE

577
00:18:45,880 --> 00:18:49,720
CENTER TO REDUCE CANCER HEALTH

578
00:18:49,720 --> 00:18:50,600
DISPARITIES.

579
00:18:50,600 --> 00:18:52,440
I PARTICULARLY POINT OUT THE K08

580
00:18:52,440 --> 00:18:53,840
WHICH IS FOR CLINICIAN

581
00:18:53,840 --> 00:18:56,520
SCIENTISTS AND THE K22 FOR

582
00:18:56,520 --> 00:18:57,480
EMERGING NPTD RESEARCHERS AND

583
00:18:57,480 --> 00:18:59,440
THEN THE 3 AWARDS BELOW THE

584
00:18:59,440 --> 00:19:01,760
GRAPHIC WHICH ARE INSTITUTIONAL

585
00:19:01,760 --> 00:19:05,120
AWARDS, THE T32, K12 AND R25 ALL

586
00:19:05,120 --> 00:19:06,520
OF WHICH HAVE EXAMPLES OF

587
00:19:06,520 --> 00:19:07,920
ENGAGEMENT IN THIS AREA.

588
00:19:07,920 --> 00:19:11,720
THE NEXT SLIDE, THEN, ADDS A

589
00:19:11,720 --> 00:19:13,120
LITTLE DETAIL, THIS IS TO THE

590
00:19:13,120 --> 00:19:14,400
SNAPSHOT OF OUR OFFERINGS, JUST

591
00:19:14,400 --> 00:19:17,320
TO GIVE YOU AN IDEA OF WHERE THE

592
00:19:17,320 --> 00:19:20,840
NUMBERS OF GRANTS FROM US IN

593
00:19:20,840 --> 00:19:22,200
CHCRD AND THE DOLLARS INVESTED

594
00:19:22,200 --> 00:19:25,040
ARE, SO YOU CAN SEE THE

595
00:19:25,040 --> 00:19:28,720
MECHANISM I MENTIONED, THE K08,

596
00:19:28,720 --> 00:19:31,200
THE K12, R25 AND T32, THESE ARE

597
00:19:31,200 --> 00:19:33,400
MAJOR COMPONENT ANDS WE INVEST

598
00:19:33,400 --> 00:19:33,920
HEAVRY IN THIS.

599
00:19:33,920 --> 00:19:36,480
WE ALSO DID A BRIEF SURVEY OF

600
00:19:36,480 --> 00:19:38,120
ACTING GRANTS AND LOOKED AT

601
00:19:38,120 --> 00:19:39,320
PATENTS ASSOCIATED WITH THEM AS

602
00:19:39,320 --> 00:19:40,680
1 MEASURE OF ACTIVITY THAT LEADS

603
00:19:40,680 --> 00:19:42,520
TO THE CLINIC DOESN'T MEAN IT'S

604
00:19:42,520 --> 00:19:43,600
THE THERAPEUTICMENT OF COURSE,

605
00:19:43,600 --> 00:19:45,360
THESE ARE VERY MUCH QUICK LOOKS,

606
00:19:45,360 --> 00:19:48,360
IF THE COMMITTEE DESIRES A MORE

607
00:19:48,360 --> 00:19:49,480
INDEPTH ANALYSIS OF COURSE, WE

608
00:19:49,480 --> 00:19:51,280
WOULD BE HAPPY TO DO THAT AND

609
00:19:51,280 --> 00:19:52,200
PARTICIPATE IN THAT BUT I WANTED

610
00:19:52,200 --> 00:19:53,600
TO GIVE YOU SOMETHING, SO THERE

611
00:19:53,600 --> 00:19:57,440
ARE A HANDFUL OF PATENTS

612
00:19:57,440 --> 00:19:59,360
ASSOCIATED WITH OUR K12

613
00:19:59,360 --> 00:20:00,520
PROGRAMS, R25S AND T32s.

614
00:20:00,520 --> 00:20:03,680
AND THE NEXT SLIDE SHOWS YOU THE

615
00:20:03,680 --> 00:20:05,320
CURRENT K08 PORTFOLIO, SO THESE

616
00:20:05,320 --> 00:20:07,160
ARE THE AWARDS THAT WERE MADE IN

617
00:20:07,160 --> 00:20:11,200
RESPONSE TO THE LAST 3 ROUNDS OF

618
00:20:11,200 --> 00:20:12,280
PROGRAM ANNOUNCEMENTS AND IN

619
00:20:12,280 --> 00:20:14,320
THESE 3 PROGRAM ANNOUNCEMENTS

620
00:20:14,320 --> 00:20:16,680
WE'VE HAD 3 ANNOUNCEMENTS IN

621
00:20:16,680 --> 00:20:19,200
PARALLEL, 1 FOR CLINICAL TRIALS,

622
00:20:19,200 --> 00:20:20,320
1 FOR CLINICAL TRIALS

623
00:20:20,320 --> 00:20:21,920
NONAPOPTOTIC THE ALLOWED, AND

624
00:20:21,920 --> 00:20:23,440
FOR FOR BASIC STUDIES WITH

625
00:20:23,440 --> 00:20:25,600
HUMANS FOR WHICH WE HAVE NO

626
00:20:25,600 --> 00:20:26,000
AWARD.

627
00:20:26,000 --> 00:20:28,520
SO WHAT I'M SHOWING YOU HERE IS

628
00:20:28,520 --> 00:20:30,520
THAT THERE ARE K08S FOCUSED ON

629
00:20:30,520 --> 00:20:33,440
CLINICAL TRIALS IN THE

630
00:20:33,440 --> 00:20:34,840
3--REWARDING A RESPONSE TO THE 3

631
00:20:34,840 --> 00:20:36,760
LAST PROGRAM ANNOUNCE WANTS, THE

632
00:20:36,760 --> 00:20:38,920
P A 20 AND THERE ARE 18 WITH

633
00:20:38,920 --> 00:20:40,000
CLINICAL TRIALS, AND 40 WITHOUT

634
00:20:40,000 --> 00:20:42,480
THEM SO CLEARLY SOME OF OUR K08

635
00:20:42,480 --> 00:20:44,480
FOLKS ARE WORKING ON AREAS

636
00:20:44,480 --> 00:20:47,160
RELATED DIRECTLY TO TRANSLATING

637
00:20:47,160 --> 00:20:47,680
TO THE CLINIC.

638
00:20:47,680 --> 00:20:50,960
THE NEXT SLIDE IS AGAIN A QUICK

639
00:20:50,960 --> 00:20:52,640
LOOK WE'RE JUST DOING KEY WORD

640
00:20:52,640 --> 00:20:55,560
HITS HERE IN OUR EXISTING

641
00:20:55,560 --> 00:20:57,200
PORTFOLIOS, THE T32s AND THE

642
00:20:57,200 --> 00:21:00,320
R25s IN THIS CASE, WORDS LIKE

643
00:21:00,320 --> 00:21:01,520
REGULATORY, FDA AND INTO THE

644
00:21:01,520 --> 00:21:05,440
CLIRNIC AND THERE'S A HANDFUL OF

645
00:21:05,440 --> 00:21:08,040
GRANTS THAT SHOW UP, THIS IS ALL

646
00:21:08,040 --> 00:21:09,600
DATA FROM REPORTER, IT'S PUBLIC

647
00:21:09,600 --> 00:21:10,920
INFORMATION, CAN YOU MAKE A

648
00:21:10,920 --> 00:21:11,720
JUDGMENT FOR YOURSELF WHETHER

649
00:21:11,720 --> 00:21:13,400
YOU THINK THESE ARE RELEVANT TO

650
00:21:13,400 --> 00:21:16,840
THE ISSUE THAT THE COMMITTEE IS

651
00:21:16,840 --> 00:21:17,120
CONSIDERING.

652
00:21:17,120 --> 00:21:19,280
I WILL THEN ON THE LAST SLIDE

653
00:21:19,280 --> 00:21:22,960
JUST POINT OUT 1 R25 THAT I

654
00:21:22,960 --> 00:21:24,040
THINK IS PARTICULARLY RELEVANT

655
00:21:24,040 --> 00:21:27,440
IF WE CAN GO TO THE NEXT SLIDE,

656
00:21:27,440 --> 00:21:28,880
PLEASE WHICH IS THE 1 THAT

657
00:21:28,880 --> 00:21:32,280
SUPPORTS THE SO CALLED VAIL

658
00:21:32,280 --> 00:21:34,280
WORKSHOP TOGETHER WITH AACR AND

659
00:21:34,280 --> 00:21:36,920
ASCO, THIS IS A WORK LONG

660
00:21:36,920 --> 00:21:39,600
WORKSHOP DESIGNED TO TRAIN EARLY

661
00:21:39,600 --> 00:21:40,640
INVESTIGATORS IN THE BEST

662
00:21:40,640 --> 00:21:43,240
PRACTICE OF EARLY TRIAL DESIGN.

663
00:21:43,240 --> 00:21:44,720
THEY RECENTLY PUBLISHED THEIR

664
00:21:44,720 --> 00:21:46,480
FINDINGS, I REPORT IT UP THERE,

665
00:21:46,480 --> 00:21:52,120
BUT THEY REPORTED THAT

666
00:21:52,120 --> 00:21:57,040
BACKGROUND OF STUDENTS ATTENDED

667
00:21:57,040 --> 00:21:58,120
THAL WORKSHOP, IT'S VERY

668
00:21:58,120 --> 00:21:59,520
COMPETITIVE AND AT THE END OF

669
00:21:59,520 --> 00:22:01,120
THE WORKSHOP ACCORDING TO THE

670
00:22:01,120 --> 00:22:03,720
PUBLICATION, THE FACULTY RATED

671
00:22:03,720 --> 00:22:06,600
92-100% OF THE STUDENTS BRING A

672
00:22:06,600 --> 00:22:08,800
PROTOCOL AND SOME MUCH WORKSHOP

673
00:22:08,800 --> 00:22:10,960
IS SMALL GROUP, WORK, AND

674
00:22:10,960 --> 00:22:12,480
PROTOCOL DEVELOPMENT GROUPS, THE

675
00:22:12,480 --> 00:22:15,240
FACULTY RATED THE VAST MAJORITY

676
00:22:15,240 --> 00:22:18,480
OF THESE PROTOCOLS AS READY FOR

677
00:22:18,480 --> 00:22:20,080
IRB SUBMISSION WHICH THE THEY

678
00:22:20,080 --> 00:22:21,840
RETURN HOME TO THEIR HOME

679
00:22:21,840 --> 00:22:22,280
INSTITUTIONS.

680
00:22:22,280 --> 00:22:25,280
SO THIS IS NOT ENCOMPASS THE

681
00:22:25,280 --> 00:22:27,320
ENTIRE CONTINUUM THAT

682
00:22:27,320 --> 00:22:28,680
DR. HEINBERGER ILLUSTRATED, THAT

683
00:22:28,680 --> 00:22:31,120
WOULD BE VERY DIFFICULT IN A 1

684
00:22:31,120 --> 00:22:33,280
WEEK WORKSHOP BUT IT'S CERTAINLY

685
00:22:33,280 --> 00:22:36,680
TRANSFORMS AN IDEA OF

686
00:22:36,680 --> 00:22:38,200
POTENTIALLY TO A PRACTICAL, YOU

687
00:22:38,200 --> 00:22:39,760
KNOW DOCUMENT THAT CAN BE

688
00:22:39,760 --> 00:22:42,440
IMPLEMENTED AT TRIAL THAT CAN BE

689
00:22:42,440 --> 00:22:43,240
HOPEFULLY LAUNCHED.

690
00:22:43,240 --> 00:22:44,800
THIS YEAR'S WORKSHOP HAD A KEY

691
00:22:44,800 --> 00:22:47,400
NOTE BY DR. KALEN AND IT WAS

692
00:22:47,400 --> 00:22:48,440
VERY INSPIRATIONAL AND

693
00:22:48,440 --> 00:22:50,640
INSTRUCTIVE SORT OF ON HOW

694
00:22:50,640 --> 00:22:51,440
MODERN CLINICAL TRIAL DESIGN CAN

695
00:22:51,440 --> 00:22:53,240
BE DONE AND THE PEOPLE IN THE

696
00:22:53,240 --> 00:22:56,280
WORKSHOP, THE FACULTY OR

697
00:22:56,280 --> 00:22:57,120
EXPERTS, BIOSTATISTICIANS,

698
00:22:57,120 --> 00:22:57,760
CLINICAL TRIALIST AND SO ON, SO

699
00:22:57,760 --> 00:23:01,640
THIS IS I THINK A MODEL THAT 1

700
00:23:01,640 --> 00:23:03,840
COULD SERIOUSLY CONSIDER IN, YOU

701
00:23:03,840 --> 00:23:04,800
KNOW, IN THE--WHICH THE

702
00:23:04,800 --> 00:23:07,640
COMMUNITY COULD USE, TO SUPPORT

703
00:23:07,640 --> 00:23:09,040
EFFORTS IN THIS SPECTRUM.

704
00:23:09,040 --> 00:23:10,920
AND I THINK THAT'S MY LAST

705
00:23:10,920 --> 00:23:11,120
SLIDE.

706
00:23:11,120 --> 00:23:12,960
I DO HAVE A COUPLE OF BACK UP

707
00:23:12,960 --> 00:23:13,920
SLIDES IN CASE PEOPLE WANT TO

708
00:23:13,920 --> 00:23:15,200
LEARN MORE ABOUT THE MECHANISMS

709
00:23:15,200 --> 00:23:16,560
BUT THAT'S WHAT I WANTED TO

710
00:23:16,560 --> 00:23:21,640
SHARE WITH THE COMMITTEE TODAY. 

711
00:23:21,640 --> 00:23:21,880
THANKS.

712
00:23:21,880 --> 00:23:23,880
>> OLIVER, I THINK YOU
HAVE AN

713
00:23:23,880 --> 00:23:26,080
INTERNAL CURRICULUM YOU TEACH

714
00:23:26,080 --> 00:23:27,440
FOR THE INTRAMURAL

715
00:23:27,440 --> 00:23:27,920
INVESTIGATORS, CORRECT?

716
00:23:27,920 --> 00:23:31,480
>> WE DO, WE HAVE A COURSE

717
00:23:31,480 --> 00:23:33,240
CALLED TRACO, I HAVE TO SAY IT'S

718
00:23:33,240 --> 00:23:36,040
A BIT OF A SURVEY COURSE, NOT

719
00:23:36,040 --> 00:23:37,800
NEARLY AS INDEPTH AS WHAT WOULD

720
00:23:37,800 --> 00:23:45,800
BE REQUIRED, THIS IS AN LECTURE

721
00:23:45,800 --> 00:23:47,400
COURSE THAT GIVES YOU AN IDEA OF

722
00:23:47,400 --> 00:23:49,080
THE LANDSCAPE OF WHAT IT MEANS

723
00:23:49,080 --> 00:23:50,160
TO IDENTIFY TARGETS AND DEVELOP

724
00:23:50,160 --> 00:23:52,280
THINGS BUT I DON'T THINK IT

725
00:23:52,280 --> 00:23:53,840
COMES--MOVES ALONG ENOUGH TO THE

726
00:23:53,840 --> 00:23:56,720
POINT WHERE SOMEONE WOULD BE AS

727
00:23:56,720 --> 00:23:57,800
CAPABLE AS I THINK YOU WOULD

728
00:23:57,800 --> 00:24:00,280
LIKE THEM TO BE FROM YOUR

729
00:24:00,280 --> 00:24:01,560
INTRODUCTION, BUT CERTAINLY A

730
00:24:01,560 --> 00:24:05,920
FOUNDATION 1 COULD BUILD ON.

731
00:24:05,920 --> 00:24:06,760
>> SO CERTAINLY, WE CAN
OPEN IT

732
00:24:06,760 --> 00:24:09,480
UP TO THE FLOOR FOR ADDITIONAL

733
00:24:09,480 --> 00:24:12,880
DISCUSSION OR THOUGHTS ON THE

734
00:24:12,880 --> 00:24:16,360
NEED OR THE PRIORITIZATION FOR

735
00:24:16,360 --> 00:24:16,800
SOMETHING LIKE THIS?

736
00:24:16,800 --> 00:24:18,360
I KNOW ANN HAS HAD A LONG

737
00:24:18,360 --> 00:24:20,560
HISTORY OF DOING THESE KINDS OF

738
00:24:20,560 --> 00:24:22,320
THINGS AND FRANCIS AS WELL,

739
00:24:22,320 --> 00:24:24,240
THROUGH THE SPORES, ET CETERA.

740
00:24:24,240 --> 00:24:27,280
>> YEAH, SO 1 THING THAT
WE DID

741
00:24:27,280 --> 00:24:28,600
AND IT DIDN'T COME UP TODAY BUT

742
00:24:28,600 --> 00:24:30,520
I THOUGHT AT THE TIME WHEN WE

743
00:24:30,520 --> 00:24:32,200
SET UP THE NANO TECHNOLOGY

744
00:24:32,200 --> 00:24:34,280
ALLIANCE FOR CANCER AT THE NCI,

745
00:24:34,280 --> 00:24:36,240
WE ALSO SET UP SOMETHING CALLED

746
00:24:36,240 --> 00:24:37,880
THE NANO TECHNOLOGY

747
00:24:37,880 --> 00:24:38,480
CHARACTERIZATION LABORATORY.

748
00:24:38,480 --> 00:24:40,400
AND ROSE, I ASSUME WE STILL HAVE

749
00:24:40,400 --> 00:24:43,440
THAT ONGOING, IT'S REALLY QUITE

750
00:24:43,440 --> 00:24:45,120
A RESOURCE AND IT ALLOWED US TO

751
00:24:45,120 --> 00:24:47,760
DID SOME THINGS EARLY ON TO KIND

752
00:24:47,760 --> 00:24:49,440
OF ENABLE THAT ENTIRE FIELD.

753
00:24:49,440 --> 00:24:51,400
AND FDA ACTUALLY PARTNERED WITH

754
00:24:51,400 --> 00:24:55,000
US ON THAT, ACTUALLY THROUGH THE

755
00:24:55,000 --> 00:24:57,560
IOTF, AND SO, THERE MAY BE AN

756
00:24:57,560 --> 00:25:00,200
OPPORTUNITY HERE TO DO--I'VE

757
00:25:00,200 --> 00:25:00,880
ALWAYS THOUGHT THERE'S AN

758
00:25:00,880 --> 00:25:02,160
OPPORTUNITY HERE TO DO SOMETHING

759
00:25:02,160 --> 00:25:03,880
LIKE THIS FOR CELL THERAPIES

760
00:25:03,880 --> 00:25:04,800
ESPECIALLY BECAUSE THERE ARE

761
00:25:04,800 --> 00:25:07,240
LOTS OF ISSUES IN TERMS OF

762
00:25:07,240 --> 00:25:08,920
STANDARDS, IT'S THERE THAT HAVE

763
00:25:08,920 --> 00:25:10,360
TO BE RESOLVED, ESPECIALLY IN

764
00:25:10,360 --> 00:25:12,880
TERMS OF SCALING, SO, YOU KNOW

765
00:25:12,880 --> 00:25:15,480
IT MIGHT BE WORTH CONSIDERING

766
00:25:15,480 --> 00:25:18,640
THAT APPROACH BECAUSE WE DO HAVE

767
00:25:18,640 --> 00:25:19,760
A GREAT MODEL, AT FREDERICK AND

768
00:25:19,760 --> 00:25:21,560
YOU KNOW IT'S BEEN IN PLACE FOR

769
00:25:21,560 --> 00:25:22,400
A LONG TIME.

770
00:25:22,400 --> 00:25:23,840
SO THAT'S 1 THING, THE OTHER

771
00:25:23,840 --> 00:25:25,800
THING THOUGH IS WE DO HAVE, AND

772
00:25:25,800 --> 00:25:27,240
ROSE, I THINK YOU ALOUDED TO

773
00:25:27,240 --> 00:25:32,200
THIS, WE DO HAVE A FEW, A FEW

774
00:25:32,200 --> 00:25:35,200
CANCER CENTERS, SAY I FEW

775
00:25:35,200 --> 00:25:36,400
PARTNERS AT NCI THAT ACTUALLY

776
00:25:36,400 --> 00:25:39,680
HAVE QUITE A BIT OF SCALE

777
00:25:39,680 --> 00:25:40,040
CAPABILITY.

778
00:25:40,040 --> 00:25:41,920
AND I'M NOT SURE THAT WE'VE EVER

779
00:25:41,920 --> 00:25:43,920
REALLY TAKEN ADVANTAGE OF THAT

780
00:25:43,920 --> 00:25:45,760
FROM AN NCI PERSPECTIVE, I THINK

781
00:25:45,760 --> 00:25:47,720
WE ENABLED OTHER PEOPLE TO TAKE

782
00:25:47,720 --> 00:25:49,600
AIDE VANTAGE OF IT AND SO, 1

783
00:25:49,600 --> 00:25:50,280
LAST TECHNOLOGY TRANSFER I WILL

784
00:25:50,280 --> 00:25:54,080
SAY, IF I LOOK AT THE CHECK

785
00:25:54,080 --> 00:25:54,880
POINT INHIBITORS, FRANKLY, I'M

786
00:25:54,880 --> 00:25:58,160
NOT SURE THAT WE WOULD HAVE

787
00:25:58,160 --> 00:25:59,320
ANSWERED THE INHIBITORS WITHOUT

788
00:25:59,320 --> 00:26:01,040
THE NCI BECAUSE WE, THROUGH THE

789
00:26:01,040 --> 00:26:03,880
RAID PROGRAM WE DID PRODUCE

790
00:26:03,880 --> 00:26:07,800
THOSE MOLECULES FOR PEOPLE WHO

791
00:26:07,800 --> 00:26:10,160
ACTUALLY WON THE NOBEL PRIZE, SO

792
00:26:10,160 --> 00:26:12,240
I THINK NCI'S PLAYED A BIG ROLE

793
00:26:12,240 --> 00:26:14,320
AND CAN PLAY AN EVEN BIGGER ROLE

794
00:26:14,320 --> 00:26:16,920
IN THE FUTURE, I THINK ROSE

795
00:26:16,920 --> 00:26:18,000
IS--AND HOWARD'S DONE A GOOD JOB

796
00:26:18,000 --> 00:26:19,680
OF KIND OF LAYING THIS ALL OUT

797
00:26:19,680 --> 00:26:21,960
BUT THERE'S A LOT OF OPPORTUNITY

798
00:26:21,960 --> 00:26:23,160
HERE, SO--THANK YOU AMY FOR

799
00:26:23,160 --> 00:26:24,160
BRINGING THIS FORWARD, I THINK

800
00:26:24,160 --> 00:26:26,720
IT'S A REAL NEED.

801
00:26:26,720 --> 00:26:29,120
>> AND 1 OF THE THINGS,
YOU JUST

802
00:26:29,120 --> 00:26:31,000
SAID, ACTUALLY KIND OF MAKES THE

803
00:26:31,000 --> 00:26:32,720
POINT EVEN FURTHER, WHICH IS THE

804
00:26:32,720 --> 00:26:35,000
FACT THAT MANY INVESTIGATORS

805
00:26:35,000 --> 00:26:39,600
AREN'T EVEN AWARE OF THE NCI,

806
00:26:39,600 --> 00:26:41,840
VARIOUS INITIATIVES, RESOURCES,

807
00:26:41,840 --> 00:26:43,600
RAID, YOU KNOW NEX, ALL THESE

808
00:26:43,600 --> 00:26:45,280
THINGS, YOU TALK TO ALMOST ANY

809
00:26:45,280 --> 00:26:46,680
INVESTIGATOR, VERY FEW OF THEM

810
00:26:46,680 --> 00:26:49,000
ARE REALLY FAMILIAR, SO, IF

811
00:26:49,000 --> 00:26:51,480
THESE--THERE WAS LET'S SAY 1-2

812
00:26:51,480 --> 00:26:53,320
YEAR LONG CURRICULUM, BASED AT

813
00:26:53,320 --> 00:26:55,520
THE NCI THROUGH LET'S SAY WEB

814
00:26:55,520 --> 00:26:58,000
BASES OR WHATEVER, PARTIALLY,

815
00:26:58,000 --> 00:27:00,960
YOU WOULD MAKE ADD ON TO THE

816
00:27:00,960 --> 00:27:02,560
ASCO COURSE THAT OLIVER ALLUDED

817
00:27:02,560 --> 00:27:04,680
TO AT THE VERY END THEN THAT

818
00:27:04,680 --> 00:27:05,960
COULD BE PART OF THE CURRICULUM

819
00:27:05,960 --> 00:27:07,440
WHICH IS ACTUALLY TO EDUCATE

820
00:27:07,440 --> 00:27:09,080
THESE INVESTIGATORS WITH REGARDS

821
00:27:09,080 --> 00:27:14,800
TO NCI, FDA RESOURCES, ET

822
00:27:14,800 --> 00:27:15,160
CETERA.

823
00:27:15,160 --> 00:27:18,320
>> IN IS FRANCIS, I HAVE 2

824
00:27:18,320 --> 00:27:18,800
COMMENTS.

825
00:27:18,800 --> 00:27:22,200
THE FIRST IS ACTUALLY

826
00:27:22,200 --> 00:27:23,480
VERIFICATION, THE CORE, THE 2

827
00:27:23,480 --> 00:27:25,000
YEAR COURSE THAT OLIVER

828
00:27:25,000 --> 00:27:28,280
PRESENTED, I THINK THAT'S

829
00:27:28,280 --> 00:27:28,560
FANTASTIC.

830
00:27:28,560 --> 00:27:33,200
I'M WONDERING IS THAT FOR EARLY

831
00:27:33,200 --> 00:27:34,240
INVESTIGATORS OR EVEN MORE

832
00:27:34,240 --> 00:27:35,320
ESTABLISHED INVESTIGATOR WHO IS

833
00:27:35,320 --> 00:27:37,240
NEED EXPERTISE IN THAT AND THEY

834
00:27:37,240 --> 00:27:39,560
COULD ALMOST BE LIKE A TRAIN THE

835
00:27:39,560 --> 00:27:41,960
TRAINER, THEY COULD GO BACK TO

836
00:27:41,960 --> 00:27:44,200
THIS AND TRAIN THE OTHER

837
00:27:44,200 --> 00:27:44,520
INSTITUTIONS.

838
00:27:44,520 --> 00:27:45,600
SO YOU CAN ANSWER THAT BUT I

839
00:27:45,600 --> 00:27:46,840
WANT TO MENTION AND TOUCH ON

840
00:27:46,840 --> 00:27:50,400
SOMETHING THAT AMY, I THINK YOU

841
00:27:50,400 --> 00:27:53,200
ALLUDED TO, NAMELY, CELL

842
00:27:53,200 --> 00:27:53,760
THERAPIES.

843
00:27:53,760 --> 00:27:55,400
CELL THERAPIES ARE CHALLENGING,

844
00:27:55,400 --> 00:27:57,320
SMALL MOLECULES CAN DO A LOT OF

845
00:27:57,320 --> 00:27:58,720
WONDER RECALL PRECLINICAL

846
00:27:58,720 --> 00:27:59,960
STUDIES, ANIMAL STUDIES AND SO

847
00:27:59,960 --> 00:28:02,640
ON BUT WHEN YOU GET TO CELL

848
00:28:02,640 --> 00:28:05,000
THERAPIES AND OF THEM WITH

849
00:28:05,000 --> 00:28:08,840
IMMUNOTHERAPY, YOU REALLY CAN'T

850
00:28:08,840 --> 00:28:12,200
DO MUCH WORK PRECLINICALLY YOU

851
00:28:12,200 --> 00:28:14,920
KNOW IN ANIMALS, AND THAT'S AS

852
00:28:14,920 --> 00:28:17,600
YOU ALL KNOW FROM YOUR OWN WORK,

853
00:28:17,600 --> 00:28:20,680
IT'S BEEN A CHALLENGE.

854
00:28:20,680 --> 00:28:23,040
I WONDER WHAT-HOW THAT CAN BE

855
00:28:23,040 --> 00:28:23,480
FACILITATED?

856
00:28:23,480 --> 00:28:26,200
I MEAN MOST OF THE BOTTLENECKS

857
00:28:26,200 --> 00:28:27,040
ARE REGULATORY, FDA, YOU KNOW

858
00:28:27,040 --> 00:28:29,360
WANT TO GO FOR THE IND AND THE

859
00:28:29,360 --> 00:28:32,360
KIND OF THINGS YOU NEED TO

860
00:28:32,360 --> 00:28:35,160
PRESENT, IT'S QUITE CHALLENGING

861
00:28:35,160 --> 00:28:36,840
AND AND I THINK TO ADVANCE THE

862
00:28:36,840 --> 00:28:39,480
FIELD, PROGRESS IN THAT AREA,

863
00:28:39,480 --> 00:28:41,160
YOU KNOW, YOU KNOW MAKES IT

864
00:28:41,160 --> 00:28:42,480
EASIER OR FINDING SOME OTHER

865
00:28:42,480 --> 00:28:46,000
PARADIGMS TO,A LOW THESE TO MOVE

866
00:28:46,000 --> 00:28:49,040
FORWARD MUCH MORE QUICKLY.

867
00:28:49,040 --> 00:28:51,440
I WONDER WHAT AMY, HAVE YOU A

868
00:28:51,440 --> 00:28:53,320
LOT OF EXPERIENCE IN THAT, WHAT

869
00:28:53,320 --> 00:28:54,640
YOUR THOUGHTS ARE?

870
00:28:54,640 --> 00:28:55,920
>> WELL, FRANCIS, YOU KNOW
YOUR

871
00:28:55,920 --> 00:28:57,040
COMMENT RIGHT NOW ALMOST MAKES

872
00:28:57,040 --> 00:28:59,280
ME THINK MORE OF AN RFA TO

873
00:28:59,280 --> 00:29:01,480
DEVELOP THE PRECLINICAL MODELS.

874
00:29:01,480 --> 00:29:04,840
AND I WANTED TO REALLY FOCUS IN

875
00:29:04,840 --> 00:29:05,280
ON TRAINING.

876
00:29:05,280 --> 00:29:07,600
I'M NOT SAYING THAT THAT'S NOT

877
00:29:07,600 --> 00:29:10,480
AN ISSUE, HOW ARE YOU THINKING

878
00:29:10,480 --> 00:29:11,560
ABOUT THAT, FRANCIS, IN THE

879
00:29:11,560 --> 00:29:14,360
CONTEXT OF A TRAINING SORT OF

880
00:29:14,360 --> 00:29:16,800
INITIATIVE BASED AT THE LEVEL OF

881
00:29:16,800 --> 00:29:20,000
THE NCI?

882
00:29:20,000 --> 00:29:20,400
>> MM-HMM.

883
00:29:20,400 --> 00:29:25,840
THAT COULD BE 1 WAY TO, APPROACH

884
00:29:25,840 --> 00:29:27,000
IT, BUT OLIVER, COULD YOU TOUCH

885
00:29:27,000 --> 00:29:29,920
ON WHETHER THE FELLOWSHIP IS FOR

886
00:29:29,920 --> 00:29:31,880
YOUNG INVESTIGATORS OR YOU KNOW

887
00:29:31,880 --> 00:29:33,280
ANYBODY WHO'S ACTIVE AND NEEDS

888
00:29:33,280 --> 00:29:36,720
THAT KIND OF TRAINING.

889
00:29:36,720 --> 00:29:38,120
>> IT'S PRIMARILY A
FELLOWSHIP

890
00:29:38,120 --> 00:29:40,520
OFFERED TO PEOPLE AT THE POST

891
00:29:40,520 --> 00:29:42,320
DOCTORAL STAGE, TO SENIOR POST

892
00:29:42,320 --> 00:29:44,120
DOCS, THE FORM OF IT IS THAT YOU

893
00:29:44,120 --> 00:29:46,200
WORK AT FDA FOR 2 YEARS,

894
00:29:46,200 --> 00:29:49,040
EMBEDDED THERE AND LEARN THEIR

895
00:29:49,040 --> 00:29:50,800
FIRST HAND WHAT THE STEPS ARE.

896
00:29:50,800 --> 00:29:52,240
DOESN'T MEAN YOU HAVE TO STAY AT

897
00:29:52,240 --> 00:29:53,760
FDA BUT MANY PEOPLE DO.

898
00:29:53,760 --> 00:29:55,160
SO YOU COULD CONCEIVABLILY TAKE

899
00:29:55,160 --> 00:29:56,120
IT AS A JUNIOR INVESTIGATOR BUT

900
00:29:56,120 --> 00:29:59,560
IT WOULD BE HARD TO FIT IT IN

901
00:29:59,560 --> 00:30:01,440
ALONGSIDE, ACTUALLY LAUNCHING

902
00:30:01,440 --> 00:30:01,960
YOUR INDEPENDENT CAREER.

903
00:30:01,960 --> 00:30:03,840
>> YEAH THAT WOULD BE
DIFFICULT

904
00:30:03,840 --> 00:30:04,480
FOR ESTABLISHED INVESTIGATORS.

905
00:30:04,480 --> 00:30:05,160
MAYBE THEY COULD BENEFIT FROM

906
00:30:05,160 --> 00:30:07,400
SOME OF THE COURSES THAT YOU

907
00:30:07,400 --> 00:30:10,720
KNOW SPECIALIZED COURSES AND

908
00:30:10,720 --> 00:30:11,240
THINGS LIKE THAT.

909
00:30:11,240 --> 00:30:12,920
WE HAVE A LOT OF ESTABLISHED

910
00:30:12,920 --> 00:30:13,800
INVESTIGATORS NEED THE

911
00:30:13,800 --> 00:30:16,960
EXPERTISE, THEY LACK IT AND IT

912
00:30:16,960 --> 00:30:18,600
HAMPERED THEIR PROGRESS IN

913
00:30:18,600 --> 00:30:20,720
DEVELOPING NEW AGENTS.

914
00:30:20,720 --> 00:30:21,560
>> OLIVER, JUST A POINT OF

915
00:30:21,560 --> 00:30:24,320
CLARSKS AND THEN I WILL

916
00:30:24,320 --> 00:30:25,600
RECOGNIZE $FINGER, HOWEVER DOES

917
00:30:25,600 --> 00:30:27,200
IT INCLUDE CURRICULUM IN THE

918
00:30:27,200 --> 00:30:28,960
MORE EARLY LIKE DRUG DEVELOPMENT

919
00:30:28,960 --> 00:30:30,920
TEST ARTICLE OR IS IT MOSTLY

920
00:30:30,920 --> 00:30:33,080
BALANCED TOWARD THE LATER STAGE

921
00:30:33,080 --> 00:30:35,200
ALREADY HAVE A TARGET, ALREADY

922
00:30:35,200 --> 00:30:36,680
HAVE TEST ARTICLES, ALREADY HAVE

923
00:30:36,680 --> 00:30:38,520
A LEAD AND YOU'RE KIND OF

924
00:30:38,520 --> 00:30:39,640
IMPLEMENTING DOWN THE IND AT

925
00:30:39,640 --> 00:30:42,120
THAT STAGE OF TWEPMENT.

926
00:30:42,120 --> 00:30:43,720
>> SO IT'S PURPOSE IS NOT
TO

927
00:30:43,720 --> 00:30:44,960
TRAIN YOU TO DEVELOP YOUR OWN

928
00:30:44,960 --> 00:30:46,400
DRUGS INTO THE CLINIC, THE

929
00:30:46,400 --> 00:30:49,200
PURPOSE IS REALLY FOR YOU TO BE

930
00:30:49,200 --> 00:30:51,760
EMBEDDED WITH AN FDA TEAM AND

931
00:30:51,760 --> 00:30:53,600
LEARN THE EXPERIENCE THAT, IT'S

932
00:30:53,600 --> 00:30:54,480
LIKE BECOMING A PROGRAM OFFICER

933
00:30:54,480 --> 00:30:58,400
FOR A COUPLE OF YEARS, YOU WOULD

934
00:30:58,400 --> 00:30:59,080
LEARN THE--THAT DISCIPLINE.

935
00:30:59,080 --> 00:31:00,880
IF YOU CHOOSE TO STAY AT FDA,

936
00:31:00,880 --> 00:31:02,800
YOU CONTINUE IN THAT ROLE, BUT

937
00:31:02,800 --> 00:31:04,080
IF YOU DEPART, YOU CAN BRING

938
00:31:04,080 --> 00:31:06,200
THAT EXPERTISE WITH YOU TO

939
00:31:06,200 --> 00:31:08,480
RESEARCH PROGRAMS IN INDUSTRY OR

940
00:31:08,480 --> 00:31:09,160
IN ACADEMIA.

941
00:31:09,160 --> 00:31:15,640
>> I WANT TO RECOGNIZE

942
00:31:15,640 --> 00:31:15,920
DR. FINKER.

943
00:31:15,920 --> 00:31:16,280
>> THANK YOU.

944
00:31:16,280 --> 00:31:17,480
CAN YOU HEAR ME ALL RIGHT?

945
00:31:17,480 --> 00:31:23,160
>> YEAH, WE CAN HEAR YOU
DOCTOR.

946
00:31:23,160 --> 00:31:25,960
>> ALL RIGHT, DR.
HEIMBERGER

947
00:31:25,960 --> 00:31:31,400
MENTIONED STEPS FOR SUCCESS OF

948
00:31:31,400 --> 00:31:33,200
THE TRAINING AND THE

949
00:31:33,200 --> 00:31:35,440
[INDISCERNIBLE], I SENT, I'M

950
00:31:35,440 --> 00:31:35,720
KIND OF--

951
00:31:35,720 --> 00:31:37,160
>> HOWARD, YOU HAVE A
REALLY BAD

952
00:31:37,160 --> 00:31:40,400
ECHO, WE CAN BE THE HEAR YOU

953
00:31:40,400 --> 00:31:40,720
DR. FING ERT,.

954
00:31:40,720 --> 00:31:42,640
>> I THINK YOU HAVE A
PHONE OR

955
00:31:42,640 --> 00:31:43,200
SOMETHING,.

956
00:31:43,200 --> 00:31:44,440
>> IT LOOKS LIKE YOU'RE
LOGGED

957
00:31:44,440 --> 00:31:45,160
IN TWICE.

958
00:31:45,160 --> 00:31:52,520
NYEAH, LET ME DO THIS. 

959
00:31:52,520 --> 00:31:54,360
IS THAT BETTER?

960
00:31:54,360 --> 00:31:54,720
IS THAT BETTER?

961
00:31:54,720 --> 00:31:56,120
>> YEAH, IT DOES SEEM TO
BE

962
00:31:56,120 --> 00:31:59,360
BETTER, YES, I'M SORRY CAN YOU

963
00:31:59,360 --> 00:32:00,520
REPEAT YOUR COMMENT?

964
00:32:00,520 --> 00:32:03,400
>> YES, SO COMING AT THIS
MORE

965
00:32:03,400 --> 00:32:09,680
FROM A PERSPECTIVE OF THE

966
00:32:09,680 --> 00:32:13,960
INDUSTRY VERSUS [INDISCERNIBLE]

967
00:32:13,960 --> 00:32:18,160
LIKE THIS FOR COUPLE DECADES

968
00:32:18,160 --> 00:32:18,760
NOW.

969
00:32:18,760 --> 00:32:26,560
>> HOWARD YOU'RE STILL
MUTTLED,

970
00:32:26,560 --> 00:32:31,160
YOU HAVE A PHONE OR A--

971
00:32:31,160 --> 00:32:32,760
>> I MUTED THE PHONE.

972
00:32:32,760 --> 00:32:35,800
>> WE STILL HAVE AN ECHO. 

973
00:32:35,800 --> 00:32:38,520
>> IS THAT BETTER?

974
00:32:38,520 --> 00:32:38,800
>> HELLO.

975
00:32:38,800 --> 00:32:40,240
>> NOW WE HAVE YOU ON THE
SCREEN

976
00:32:40,240 --> 00:32:41,600
TWICE.

977
00:32:41,600 --> 00:32:43,280
>> IS THAT BETTER?

978
00:32:43,280 --> 00:32:44,840
>> DR. FING ERT, WHILE
YOU'RE

979
00:32:44,840 --> 00:32:46,120
WORKING THROUGH THE TECHNICAL

980
00:32:46,120 --> 00:32:51,640
ISSUE CAN I MOVE ON TO

981
00:32:51,640 --> 00:32:52,680
DR. CARPPTEN.

982
00:32:52,680 --> 00:32:53,360
>> YEAH, THANK YOU.

983
00:32:53,360 --> 00:32:53,680
>> SURE.

984
00:32:53,680 --> 00:32:55,560
>> HOPEFULLY YOU CAN HEAR
ME

985
00:32:55,560 --> 00:32:56,720
OKAY?

986
00:32:56,720 --> 00:33:00,200
>> YEAH, I WAS INTRIGUED
BY THE

987
00:33:00,200 --> 00:33:01,720
FELLOWSHIP TRAINING CONCEPT AND

988
00:33:01,720 --> 00:33:03,360
IDEA PARTICULARLY AS WE--AGAIN

989
00:33:03,360 --> 00:33:06,880
AND I'LL BE THE FIRST TO SAY IT,

990
00:33:06,880 --> 00:33:07,400
TRAINING UNDERREPRESENTED

991
00:33:07,400 --> 00:33:08,840
MINORITIES IN THIS AREA.

992
00:33:08,840 --> 00:33:10,560
I KNOW THERE'S AN AMAZING

993
00:33:10,560 --> 00:33:13,280
FELLOWSHIP PROGRAM THAT'S BEEN

994
00:33:13,280 --> 00:33:16,520
CREATED TO TRAIN CLINICAL

995
00:33:16,520 --> 00:33:18,040
FELLOWS, RIGHT IN ONCOLOGY

996
00:33:18,040 --> 00:33:21,360
THROUGH, YOU KNOW INDUSTRY, AND

997
00:33:21,360 --> 00:33:24,560
NONPROFIT, I DON'T WANT TO NAME

998
00:33:24,560 --> 00:33:27,640
NAMES BUT THINGS LIKE IT WOULD

999
00:33:27,640 --> 00:33:28,680
BE AN AMAZING OPPORTUNITY.

1000
00:33:28,680 --> 00:33:29,840
WE THINK ABOUT SOME OF THE

1001
00:33:29,840 --> 00:33:32,600
MEDICAL SCHOOLS OF THE

1002
00:33:32,600 --> 00:33:33,760
HISTORICALLY BLACK COLLEGES LIKE

1003
00:33:33,760 --> 00:33:35,400
MOORE HOUSE SCHOOL OF MEDICINE,

1004
00:33:35,400 --> 00:33:38,480
HOWARD UNIVERSITY WHERE THE POST

1005
00:33:38,480 --> 00:33:39,560
DOCTORAL FELLOWS THAT COULD

1006
00:33:39,560 --> 00:33:40,960
REALLY BENEFIT FROM THAT TYPE OF

1007
00:33:40,960 --> 00:33:44,320
PROGRAM AT THE FDA, LEARNING

1008
00:33:44,320 --> 00:33:45,240
ABOUT PRECLINICAL WORK AND YOU

1009
00:33:45,240 --> 00:33:47,720
KNOW HOW THAT FITS INTO THE

1010
00:33:47,720 --> 00:33:49,080
ENTIRE DRUG DEVELOPMENT, THE

1011
00:33:49,080 --> 00:33:50,600
CRITICAL PATH FOR DRUG

1012
00:33:50,600 --> 00:33:54,080
DEVELOPMENT, SO JUST CONSIDERING

1013
00:33:54,080 --> 00:33:56,000
THAT IDEA ASLET NCI CONTINUES TO

1014
00:33:56,000 --> 00:33:58,080
WORK ON DEVELOPING PROGRAMS AND

1015
00:33:58,080 --> 00:33:59,080
PLATFORMS FOR ENHANCING

1016
00:33:59,080 --> 00:33:59,880
DIVERSITY AND BIOMEDICAL

1017
00:33:59,880 --> 00:34:02,720
RESEARCH, I THINK THIS IS THE

1018
00:34:02,720 --> 00:34:04,280
PERFECT TYPE OF CONCEPT, TO

1019
00:34:04,280 --> 00:34:08,440
ADVANCE IN THIS AREA, SO JUST

1020
00:34:08,440 --> 00:34:10,600
SOMETHING TO CONSIDER.

1021
00:34:10,600 --> 00:34:12,680
>> DR. CARPTEN, I WANT TO
SEGUE

1022
00:34:12,680 --> 00:34:14,120
ON WHAT YOU'RE SAYING AS WELL,

1023
00:34:14,120 --> 00:34:16,160
THE THINKING FROM MY PERSPECTIVE

1024
00:34:16,160 --> 00:34:20,560
IS TO HAVE SORT OF A MANY BODY

1025
00:34:20,560 --> 00:34:22,320
OF CURRICULUM AT THE NCI LEVEL

1026
00:34:22,320 --> 00:34:26,840
AND THEN WE ACTUALLY SPOKE ABOUT

1027
00:34:26,840 --> 00:34:28,920
THE VARIOUS CANCER CENTERS, ET

1028
00:34:28,920 --> 00:34:30,840
CETERA, WHAT DO YOU DO REALLY

1029
00:34:30,840 --> 00:34:31,040
WELL?

1030
00:34:31,040 --> 00:34:33,320
WHAT'S UNIQUE AND SPECIAL ABOUT

1031
00:34:33,320 --> 00:34:34,080
YOUR CANCER CENTER?

1032
00:34:34,080 --> 00:34:35,920
AND THEN THAT THERE THEIR

1033
00:34:35,920 --> 00:34:38,240
OPPORTUNITY TO TO SHINE IN THAT

1034
00:34:38,240 --> 00:34:40,560
DOMAIN, SO HOW DO YOU ADDRESS

1035
00:34:40,560 --> 00:34:42,240
DIVERSITY, CLINICAL TRIAL

1036
00:34:42,240 --> 00:34:42,520
ENROLLMENT?

1037
00:34:42,520 --> 00:34:44,640
MAYBE THAT NEEDS TO BE AT 1

1038
00:34:44,640 --> 00:34:45,440
PARTICULAR CENTER TO REALLY

1039
00:34:45,440 --> 00:34:46,760
EXCEL THAT SO THAT THEY ARE SORT

1040
00:34:46,760 --> 00:34:48,760
OF LIKE A MASTER CLASS OF HOW DO

1041
00:34:48,760 --> 00:34:51,160
YOU DO THIS AND THEN THAT FORMS

1042
00:34:51,160 --> 00:34:52,800
PART OF THAT CURRICULUM.

1043
00:34:52,800 --> 00:34:55,080
>> BECAUSE TO BE HONEST
THE

1044
00:34:55,080 --> 00:34:58,040
CANCER CENTERS STRUGGLE.

1045
00:34:58,040 --> 00:34:58,360
>> YEAH,.

1046
00:34:58,360 --> 00:34:59,680
>> SIGNIFICANTLY RIGHT
FROM IN

1047
00:34:59,680 --> 00:35:01,720
AREA AND COULD BE AN OPPORTUNITY

1048
00:35:01,720 --> 00:35:03,240
TO EXPAND.

1049
00:35:03,240 --> 00:35:09,360
>> AND ANN, YOUR HAND IS
UP?

1050
00:35:09,360 --> 00:35:10,920
>> A COUPLE THINGS, GOING
BACK

1051
00:35:10,920 --> 00:35:14,040
TO OLIVER'S DESCRIPTION OF THIS

1052
00:35:14,040 --> 00:35:15,640
FDA FELLOWSHIP IS REALLY AN

1053
00:35:15,640 --> 00:35:16,960
INTERESTING WAWZ BECAUSE WHEN WE

1054
00:35:16,960 --> 00:35:19,240
SET THAT UP THROUGH THE IOTF AND

1055
00:35:19,240 --> 00:35:21,160
I THINK OLIVER, IT WAS 2005 OR

1056
00:35:21,160 --> 00:35:22,760
SO, I THE THING WE WANTED TO

1057
00:35:22,760 --> 00:35:24,560
HAVE HAPPEN, FIRST OF ALL THESE

1058
00:35:24,560 --> 00:35:26,080
ARE MDs AND AT LEAST AT THIS

1059
00:35:26,080 --> 00:35:29,200
TIME THEY ALSO SPENT TIME IN THE

1060
00:35:29,200 --> 00:35:32,000
CLINICAL CENTER, BUT THE NCI IS

1061
00:35:32,000 --> 00:35:33,640
ALSO A REGULATED ENTITY AS FAR

1062
00:35:33,640 --> 00:35:36,200
AS FDA GOES, SO WE HAD TO BE

1063
00:35:36,200 --> 00:35:37,400
VERY KIRFUL HOW WE SET THAT UP

1064
00:35:37,400 --> 00:35:39,760
AND SO THERE ARE LOTS OF RULES

1065
00:35:39,760 --> 00:35:41,840
AND REGULATIONS BUT OLIVER MADE

1066
00:35:41,840 --> 00:35:43,600
THE POINT, THEY'RE IMMERSED IN

1067
00:35:43,600 --> 00:35:45,520
FDA, IT'S REALLY A GREAT

1068
00:35:45,520 --> 00:35:47,160
OPPORTUNITY AND THESE PEOPLE ARE

1069
00:35:47,160 --> 00:35:49,520
SNAPPED UP AS YOU CAN IMAGINE.

1070
00:35:49,520 --> 00:35:53,680
BUT I ALSO WANT TO COME BACK TO

1071
00:35:53,680 --> 00:35:55,960
THE IDEA OF MAYBE, YOU KNOW

1072
00:35:55,960 --> 00:35:57,520
CATCHING THE VAIL COURSE AND

1073
00:35:57,520 --> 00:35:59,040
USING IT TO YOUR POINT, YOU

1074
00:35:59,040 --> 00:36:00,800
KNOW, THAT'S A REALLY GOOD

1075
00:36:00,800 --> 00:36:01,800
OPPORTUNITY, IT'S A WHOLE WEEK,

1076
00:36:01,800 --> 00:36:03,760
WE TRAIN A LOT OF PEOPLE THROUGH

1077
00:36:03,760 --> 00:36:05,880
THAT COURSE AND I THINK IT COULD

1078
00:36:05,880 --> 00:36:08,080
BE, YOU KNOW NCI REALLY SORT OF

1079
00:36:08,080 --> 00:36:09,920
STEPS IN AND TAKES THE LEAD

1080
00:36:09,920 --> 00:36:11,120
THERE, SO IT MIGHT BE A GREAT

1081
00:36:11,120 --> 00:36:16,160
PLACE FOR US TO DO THAT AND BUT,

1082
00:36:16,160 --> 00:36:19,800
YOU KNOW WHAT ABOUT JUST USING

1083
00:36:19,800 --> 00:36:21,120
THE CANCER CENTER DIRECTORS GET

1084
00:36:21,120 --> 00:36:22,880
TOGETHER ALL THE TIME, I MEAN

1085
00:36:22,880 --> 00:36:24,760
NOT ALL THE TIME, DOUG BRINGS

1086
00:36:24,760 --> 00:36:26,280
THEM TOGETHER A COUPLE TIMES A

1087
00:36:26,280 --> 00:36:27,560
YEAR AND I KNOW AND HE MAY WANT

1088
00:36:27,560 --> 00:36:28,880
TO COMMENT O THAT BUT THIS IS

1089
00:36:28,880 --> 00:36:31,520
SOMETHING THAT MAYBE THE WHOLE

1090
00:36:31,520 --> 00:36:33,040
GROUP SHOULD TAKE ON, NOT JUST,

1091
00:36:33,040 --> 00:36:34,920
YOU KNOW, I THINK THAT WOULD BE

1092
00:36:34,920 --> 00:36:36,560
VERY EFFECTIVE IF THEY WOULD

1093
00:36:36,560 --> 00:36:39,800
AGREE TO DO THAT KIND OF SHARING

1094
00:36:39,800 --> 00:36:42,680
AS YOU JUST HAD 1.

1095
00:36:42,680 --> 00:36:45,240
>> DR. FING ERT, I SEE
YOUR HAND

1096
00:36:45,240 --> 00:36:45,520
IS RAISED.

1097
00:36:45,520 --> 00:36:47,800
>> YEAH, CAN YOU HEAR ME
NOW

1098
00:36:47,800 --> 00:36:48,520
WITHOUT A PROBLEM?

1099
00:36:48,520 --> 00:36:53,920
>> NO, WE STILL SEE 2 OF
YOU

1100
00:36:53,920 --> 00:36:54,160
HOWARD.

1101
00:36:54,160 --> 00:36:59,520
>> I DON'T KNOW WHAT TO
DO.

1102
00:36:59,520 --> 00:37:01,480
>> I THINK OUR MODERATOR'S
COULD

1103
00:37:01,480 --> 00:37:09,200
MUTE 1 OF HISES LINES PERHAPS.

1104
00:37:09,200 --> 00:37:11,760
NOW HE WENT AWAY.

1105
00:37:11,760 --> 00:37:13,840
>> YEAH, WE LOST HIM
ALTOGETHER

1106
00:37:13,840 --> 00:37:14,200
NOW.

1107
00:37:14,200 --> 00:37:24,720
>> MAYBE THAT'S HIS
DIGITAL

1108
00:37:32,160 --> 00:37:32,320
TWIN.

1109
00:37:32,320 --> 00:37:33,680
SNRKSZ DID YOU WANT TO SAY

1110
00:37:33,680 --> 00:37:34,040
SOMETHING.

1111
00:37:34,040 --> 00:37:35,000
>> I REALLY APPLAUD WHAT
YOU ARE

1112
00:37:35,000 --> 00:37:36,760
TRYING TO DO BUT I THINK IT'S

1113
00:37:36,760 --> 00:37:38,960
VERY IMPORTANT TO TRY TO

1114
00:37:38,960 --> 00:37:40,360
DISTINGUISH DIFFERENT PEOPLE'S

1115
00:37:40,360 --> 00:37:43,480
NEEDS, THE NEEDS FOR--I'M SURE,

1116
00:37:43,480 --> 00:37:46,120
ROSE WILL--CAN SAY THIS MUCH

1117
00:37:46,120 --> 00:37:49,240
MORE ARTICULATELY THAN ME, BUT

1118
00:37:49,240 --> 00:37:50,880
THE NEEDS FOR SETTING UP

1119
00:37:50,880 --> 00:37:52,600
CLINICAL TRIALS ARE VERY

1120
00:37:52,600 --> 00:37:54,040
DIFFERENT FROM SOMEBODY WORKING

1121
00:37:54,040 --> 00:37:59,920
IN THE LABORATORY TRYING TO DO

1122
00:37:59,920 --> 00:38:01,000
TRANSLATIONAL RESEARCH AND

1123
00:38:01,000 --> 00:38:04,640
FIGURING OUT HOW TO NEGOTIATE

1124
00:38:04,640 --> 00:38:06,080
THAT BECAUSE, YOU KNOW AS YOU

1125
00:38:06,080 --> 00:38:11,320
WERE SAYING AT THE OUTSET,

1126
00:38:11,320 --> 00:38:12,920
THATIA A MULTIFACETED PROBLEM

1127
00:38:12,920 --> 00:38:16,440
AND WRIERS DIFFERENT KINDS OF

1128
00:38:16,440 --> 00:38:16,760
INFORMATION.

1129
00:38:16,760 --> 00:38:21,000
THE REALLY IMPORTANT ASPECT IS

1130
00:38:21,000 --> 00:38:24,400
THAT HAVING RESOURCES SO YOU CAN

1131
00:38:24,400 --> 00:38:25,280
GET THAT INFORMATION BUT IF

1132
00:38:25,280 --> 00:38:26,440
YOU'RE TRYING TO DO IT IN THE

1133
00:38:26,440 --> 00:38:27,720
LAB AND YOU HAVEN'T DONE IT

1134
00:38:27,720 --> 00:38:30,240
BEFORE, I JUST THINK IT'S REALLY

1135
00:38:30,240 --> 00:38:32,960
IMPORTANT TO TALK WITH SOMEBODY

1136
00:38:32,960 --> 00:38:37,480
WHO KNOWS WHAT IS GOING ON

1137
00:38:37,480 --> 00:38:38,880
BECAUSE YOU'LL HAVE YOUR OWN SET

1138
00:38:38,880 --> 00:38:41,960
OF QUESTIONS THAT WILL PROBABLY

1139
00:38:41,960 --> 00:38:51,640
BE UNIQUE TO YOU AND SPECIFIC TO

1140
00:38:51,640 --> 00:38:52,040
YOU.

1141
00:38:52,040 --> 00:38:52,640
>> KAREN?

1142
00:38:52,640 --> 00:38:54,200
>> THANKS SO MUCH, DOUG,
THAT'S

1143
00:38:54,200 --> 00:38:57,120
SIM TO WHAT I WAS THINKING, SOME

1144
00:38:57,120 --> 00:39:00,120
INSTITUTIONS ACTUALLY DO NOT

1145
00:39:00,120 --> 00:39:04,800
SUPPORT SOME OF THE I. P. THAT

1146
00:39:04,800 --> 00:39:06,040
IS REALLY PART OF THIS WORK AND

1147
00:39:06,040 --> 00:39:07,320
I WOULD LIKE THE IDEA OF MAYBE

1148
00:39:07,320 --> 00:39:08,960
THINKING ABOUT THE CANCER CENTER

1149
00:39:08,960 --> 00:39:10,960
DIRECTORS AND EVEN EDUCATING

1150
00:39:10,960 --> 00:39:12,680
THEM, PERHAPS ABOUT THE

1151
00:39:12,680 --> 00:39:14,960
IMPORTANCE OF HELPING TO DRIVE

1152
00:39:14,960 --> 00:39:16,800
SOME OF THE INNOVATION BY GOING

1153
00:39:16,800 --> 00:39:18,760
BACK TO THE INSTITUTIONS, HAVING

1154
00:39:18,760 --> 00:39:20,200
CONVERSATIONS ABOUT THE

1155
00:39:20,200 --> 00:39:21,600
IMPORTANCE OF SUPPORTING

1156
00:39:21,600 --> 00:39:23,320
INVESTIGATORS, WHO DO WANT TO

1157
00:39:23,320 --> 00:39:24,280
TAKE THIS TRACK BECAUSE FRANKLY

1158
00:39:24,280 --> 00:39:26,480
THERE ARE SOME INSTITUTIONS THAT

1159
00:39:26,480 --> 00:39:28,040
DISSUADE THAT AND I THINK THAT'S

1160
00:39:28,040 --> 00:39:30,000
GOING TO BE AN IMPORTANT THING

1161
00:39:30,000 --> 00:39:31,280
TO OVERCOME, BECAUSE AGAIN, TO

1162
00:39:31,280 --> 00:39:33,000
YOUR POINT, WE DON'T WANT

1163
00:39:33,000 --> 00:39:33,600
INVESTIGATORS REALLY EXCITED

1164
00:39:33,600 --> 00:39:35,280
ABOUT THIS AND THEN THERE

1165
00:39:35,280 --> 00:39:36,360
INSTITUTION SAYS, OH NO, WE WILL

1166
00:39:36,360 --> 00:39:38,520
NOT HELP YOU AND,A CYST YOU WITH

1167
00:39:38,520 --> 00:39:40,480
THIS IP OR THEY TAKE ALL THE IP

1168
00:39:40,480 --> 00:39:41,800
FROM THE INVESTIGATOR AS WELL.

1169
00:39:41,800 --> 00:39:43,120
THAT'S THE OTHER COMPONENT.

1170
00:39:43,120 --> 00:39:45,040
SO THERE DOES NEED TO BE SOME

1171
00:39:45,040 --> 00:39:51,840
EDUCATION AT THE INSTITUTIONAL

1172
00:39:51,840 --> 00:39:56,000
LEVEL AS WELL.

1173
00:39:56,000 --> 00:39:56,880
>> INTERESTING, OKAY.

1174
00:39:56,880 --> 00:39:58,680
>> SO PERHAPS WE'RE NOT
LOOKING

1175
00:39:58,680 --> 00:40:01,040
AT 1 PERI SAY, COMING BA BEING

1176
00:40:01,040 --> 00:40:03,000
TO DOUG'S POINT, MAYBE WE'RE NOT

1177
00:40:03,000 --> 00:40:04,080
LOOKING AT 1 PER SE SPECIFIC

1178
00:40:04,080 --> 00:40:05,280
COURSE BUT MAYBE A SERIES OF

1179
00:40:05,280 --> 00:40:07,160
COURSES THAT NEED TO BE SORT OF

1180
00:40:07,160 --> 00:40:08,320
SET UP, DEPENDING ON AND THEN

1181
00:40:08,320 --> 00:40:11,800
YOU CAN PICK WHAT YOU NEED IN

1182
00:40:11,800 --> 00:40:13,680
YOUR GIVEN SCENARIO, TAKING AS A

1183
00:40:13,680 --> 00:40:15,520
MODEL WHAT MAYBE WHAT OLIVER AS

1184
00:40:15,520 --> 00:40:17,280
DONE AT THE INTERFACE OF THE

1185
00:40:17,280 --> 00:40:19,720
IND, AND THE FDA, MAYBE EARLIER

1186
00:40:19,720 --> 00:40:21,240
IN THE PRECLINICAL PIPELINE,

1187
00:40:21,240 --> 00:40:22,720
THEN ALLOWING THEM THE SERVICES

1188
00:40:22,720 --> 00:40:23,680
THAT ROSE HAS ALREADY TALKED

1189
00:40:23,680 --> 00:40:27,360
ABOUT AS FAR AS THE MORE SORT OF

1190
00:40:27,360 --> 00:40:27,800
FOCUS QUESTION.

1191
00:40:27,800 --> 00:40:30,160
I'M A LITTLE CONCERNED ABOUT NOT

1192
00:40:30,160 --> 00:40:31,520
PROVIDING SOME KIND OF

1193
00:40:31,520 --> 00:40:33,040
CURRICULUM THOUGH BECAUSE AS

1194
00:40:33,040 --> 00:40:35,520
ROSE HAS ALREADY ALLUDED TO, A

1195
00:40:35,520 --> 00:40:36,920
LOT OF TIMES THEY DON'T REALIZE

1196
00:40:36,920 --> 00:40:39,000
WHAT THAT I HAVE DON'T KNOW.

1197
00:40:39,000 --> 00:40:42,120
AND SO, THEY MAY COME TO A VERY

1198
00:40:42,120 --> 00:40:42,960
SPECIFIC POINTED QUESTION AND

1199
00:40:42,960 --> 00:40:45,520
SAY, OKAY, HOW DO I DO X AND

1200
00:40:45,520 --> 00:40:46,720
THEY ADDRESS THAT QUESTION BUT

1201
00:40:46,720 --> 00:40:48,120
THEN THEY DIDN'T REALIZE, OKAY,

1202
00:40:48,120 --> 00:40:50,560
ALL THESE OTHER THINGS NEEDED TO

1203
00:40:50,560 --> 00:40:51,960
ACTUALLY BE CONSIDERED, SO I'M

1204
00:40:51,960 --> 00:40:54,440
WONDERING IF WE CAN USE OLIVERS

1205
00:40:54,440 --> 00:40:56,320
MODEL FOR THE FDA MAYBE FOR A

1206
00:40:56,320 --> 00:40:58,520
VERY SIMILAR SORT OF COURSE WORK

1207
00:40:58,520 --> 00:41:02,200
EARLIER AND THEN, YOU HAVE SORT

1208
00:41:02,200 --> 00:41:03,600
OF THIS DEPENDS ON WHAT YOU NEED

1209
00:41:03,600 --> 00:41:06,120
DEPENDING ON YOUR PROJECTS, ET

1210
00:41:06,120 --> 00:41:07,320
CETERA WHERE IN THAT CONTINUUM,

1211
00:41:07,320 --> 00:41:10,480
YOU WANT TO DO YOUR COURSE WORK

1212
00:41:10,480 --> 00:41:10,720
AT.

1213
00:41:10,720 --> 00:41:13,040
OLIVER, YOU HAD YOUR HAND UP?

1214
00:41:13,040 --> 00:41:14,680
>> YES, I MEAN, I--1 THING
I

1215
00:41:14,680 --> 00:41:15,560
WOULD LIKE TO MENTION OR

1216
00:41:15,560 --> 00:41:21,560
EMPHASIZE IS THAT THE R25 CANCER

1217
00:41:21,560 --> 00:41:22,320
RESEARCH EDUCATION MECHANISM,

1218
00:41:22,320 --> 00:41:24,360
PARTICULARLY THE COURSES FOR

1219
00:41:24,360 --> 00:41:26,320
SKILLS DEVELOPMENT OF WHICH THE

1220
00:41:26,320 --> 00:41:27,800
VAIL WORKSHOP IS AN EXAMPLE,

1221
00:41:27,800 --> 00:41:30,160
MIGHT BE A GOOD MODEL.

1222
00:41:30,160 --> 00:41:31,880
WE HAVE HAD IN THE LAST FEW

1223
00:41:31,880 --> 00:41:35,200
YEARS SOMETHING WE CALLED THE

1224
00:41:35,200 --> 00:41:38,000
NASDAQ CONSORTIUM IN SDC WHICH

1225
00:41:38,000 --> 00:41:39,320
IS AN UNFORTUNATE COINAGE, BUT

1226
00:41:39,320 --> 00:41:42,600
DOESN'T HAVE TO DO ANYTHING WITH

1227
00:41:42,600 --> 00:41:44,360
STOCK MARKETS NEXT I WAS GOING

1228
00:41:44,360 --> 00:41:45,280
TO ASK THAT.

1229
00:41:45,280 --> 00:41:47,320
>> IT WAS A COORDINATED
SET OF

1230
00:41:47,320 --> 00:41:49,160
R25 GRANTS.

1231
00:41:49,160 --> 00:41:50,280
IT WAS AN INTERESTING EXPERIMENT

1232
00:41:50,280 --> 00:41:51,360
IN TRYING TO COORDINATE THAT,

1233
00:41:51,360 --> 00:41:54,920
FROM WHAT YOU'RE SAYING,

1234
00:41:54,920 --> 00:41:56,040
DR. HEIMBERGER, 1 COULD ENVISION

1235
00:41:56,040 --> 00:41:58,200
A SERIES OF COURSES PERHAPS FROM

1236
00:41:58,200 --> 00:41:59,040
SEPARATE INSTITUTIONS THAT ARE

1237
00:41:59,040 --> 00:42:00,960
COORDINATED IN A WAY THAT THEY

1238
00:42:00,960 --> 00:42:03,760
COVER THE CONTINUUM AND WHERE

1239
00:42:03,760 --> 00:42:04,800
THE LEARNERS MIGHT BE PASSED

1240
00:42:04,800 --> 00:42:07,440
FROM 1 COURSE TO ANOTHER FOR 1

1241
00:42:07,440 --> 00:42:08,480
TO A BETTER EXPRESSION.

1242
00:42:08,480 --> 00:42:09,000
JUST A THOUGHT.

1243
00:42:09,000 --> 00:42:10,520
WE DON'T HAVE A READY MADE

1244
00:42:10,520 --> 00:42:11,760
MECHANISM FOR THAT BUT CERTAINLY

1245
00:42:11,760 --> 00:42:15,880
WE WOULD BE WILLING TO EXPLORE

1246
00:42:15,880 --> 00:42:17,600
THAT, THANK YOU.

1247
00:42:17,600 --> 00:42:19,840
>> DR. LOWY, YOUR HAND IS
UP?

1248
00:42:19,840 --> 00:42:20,120
>> THANKS.

1249
00:42:20,120 --> 00:42:21,600
I WANTED TO COMMENT ON SOMETHING

1250
00:42:21,600 --> 00:42:23,320
THAT KAREN WAS SAYING WHICH IS

1251
00:42:23,320 --> 00:42:27,560
THAT WHEN IT COMES TO THE ISSUE

1252
00:42:27,560 --> 00:42:28,480
OF INTELLECTUAL PROPERTY, MOST

1253
00:42:28,480 --> 00:42:32,840
OF US ARE NOT COMPETENT TO KNOW

1254
00:42:32,840 --> 00:42:33,880
THAT OUR WONDERFUL DISCOVERY

1255
00:42:33,880 --> 00:42:37,840
WHICH IS OF COURSE UNIQUE HAS,

1256
00:42:37,840 --> 00:42:42,480
YOU KNOW THE POTENTIAL FOR

1257
00:42:42,480 --> 00:42:44,440
CLINICAL EXPLOITATION AND

1258
00:42:44,440 --> 00:42:47,040
DEVELOPMENT AND YOU REALLY NEED

1259
00:42:47,040 --> 00:42:50,600
TO HAVE SOME KIND OF GROUP OF

1260
00:42:50,600 --> 00:42:54,720
EXPERTS TO ADVISE YOU ABOUT THAT

1261
00:42:54,720 --> 00:42:55,400
REGARDLESS OF--ALMOST REGARDLESS

1262
00:42:55,400 --> 00:42:56,720
OF WHO YOU ARE.

1263
00:42:56,720 --> 00:42:59,360
IN THE INTRAMURAL PROGRAM AT

1264
00:42:59,360 --> 00:43:02,280
NCI, WE HAVE THE TECH TRANSFER

1265
00:43:02,280 --> 00:43:04,320
BRANCH AND THE STANDING

1266
00:43:04,320 --> 00:43:06,600
COMMITTEE THAT MEETS REGULARLY

1267
00:43:06,600 --> 00:43:09,040
TO GO OVER EMPLOYEE INVENTION

1268
00:43:09,040 --> 00:43:11,240
REPORTS AND THEN TO MAKE

1269
00:43:11,240 --> 00:43:12,600
DECISIONS ABOUT WHETHER THEY

1270
00:43:12,600 --> 00:43:13,800
SHOULD GO FORWARD OR NOT.

1271
00:43:13,800 --> 00:43:16,200
I JUST THINK THERE'S NO

1272
00:43:16,200 --> 00:43:20,320
SUBSTITUTE FOR HAVING SOME KIND

1273
00:43:20,320 --> 00:43:21,440
OF FORMAL PROCESS.

1274
00:43:21,440 --> 00:43:23,440
IT FORCES THE INVEBTORS TO

1275
00:43:23,440 --> 00:43:26,320
BASICALLY DESCRIBE WHAT HAVE

1276
00:43:26,320 --> 00:43:27,920
THEY DONE OR WHAT IS THEIR

1277
00:43:27,920 --> 00:43:29,800
VISION FOR WHAT THE POTENTIAL IS

1278
00:43:29,800 --> 00:43:33,040
AND THEN FOR A GROUP OF PEOPLE

1279
00:43:33,040 --> 00:43:35,120
WHO ARE NOT DIRECTLY INVOLVED IN

1280
00:43:35,120 --> 00:43:36,240
IT TO SAY, HERE'S LAWEDDER DALE

1281
00:43:36,240 --> 00:43:40,160
WE THINK THE POTENTIAL IS AND

1282
00:43:40,160 --> 00:43:43,160
IT'S UNIQUENESS.

1283
00:43:43,160 --> 00:43:46,800
--ITS UNIQUENESS.

1284
00:43:46,800 --> 00:43:47,200
>> DR. BARKER?

1285
00:43:47,200 --> 00:43:47,880
>> YEAH, JUST 1 MORE
COMMENT AND

1286
00:43:47,880 --> 00:43:49,400
I THINK DOUG MADE THIS COMMENT,

1287
00:43:49,400 --> 00:43:51,840
YOU KNOW SO A BUNCH OF THIS IS

1288
00:43:51,840 --> 00:43:53,240
AVAILABLE THROUGH NCI AND I

1289
00:43:53,240 --> 00:43:58,080
THINK PART OF OUR ISSUE IS, I

1290
00:43:58,080 --> 00:44:00,080
THINK ROSE'S COMMENT ON WHAT IS

1291
00:44:00,080 --> 00:44:01,200
AN ALMOST BESPOKE PROGRAM.

1292
00:44:01,200 --> 00:44:02,720
YOU CAN CALL IN AND GET

1293
00:44:02,720 --> 00:44:07,040
CONSULTATION ON WHERE YOU ARE IN

1294
00:44:07,040 --> 00:44:07,880
YOUR PROCESS, WHAT ADVICE YOU

1295
00:44:07,880 --> 00:44:09,280
KNOW THAT CAN BE GIIVE WHETHER

1296
00:44:09,280 --> 00:44:11,560
YOU'RE FAR INTO THE IND PROCESS

1297
00:44:11,560 --> 00:44:13,560
OR EARLY ON IN SCALE UP OR YOU

1298
00:44:13,560 --> 00:44:16,400
KNOW WHAT DO I NEED TO DO IN

1299
00:44:16,400 --> 00:44:17,320
PRECLINICAL TOXICOLOGY, ET

1300
00:44:17,320 --> 00:44:19,440
CETERA, THE WHOLE GAMUT, SO THAT

1301
00:44:19,440 --> 00:44:20,800
I--I DON'T THINK THAT A LOT OF

1302
00:44:20,800 --> 00:44:22,600
PEOPLE KNOW ABOUT THAT PROGRAM,

1303
00:44:22,600 --> 00:44:24,480
I THINK IT'S REALLY A FABULOUS

1304
00:44:24,480 --> 00:44:25,760
PROGRAM, THE OTHER THING IS LIKE

1305
00:44:25,760 --> 00:44:27,080
THE RAID PROGRAM, THERE'S SO

1306
00:44:27,080 --> 00:44:29,320
MUCH AT THE NCI THAT PEOPLE CAN

1307
00:44:29,320 --> 00:44:32,480
ACCESS ALREADY, AND SO, 1 OF THE

1308
00:44:32,480 --> 00:44:34,680
THINGS THAT WOULD BE GREAT IS IF

1309
00:44:34,680 --> 00:44:35,840
PEOPLE JUST KNEW MORE ABOUT

1310
00:44:35,840 --> 00:44:37,280
THOSE THINGS AND IT'S ALWAYS A

1311
00:44:37,280 --> 00:44:38,320
PROBLEM, BUT YOU KNOW I THINK

1312
00:44:38,320 --> 00:44:39,800
IT'S SOMETHING WE SHOULD THINK,

1313
00:44:39,800 --> 00:44:41,560
HOW COULD WE HELP IN THAT

1314
00:44:41,560 --> 00:44:41,960
REGARD.

1315
00:44:41,960 --> 00:44:44,760
AGAIN, IT MAY COME BACK TO THE

1316
00:44:44,760 --> 00:44:55,240
CANCER CENTERS UNDERSTANDING

1317
00:44:58,040 --> 00:44:58,360
WHAT'S AVAILABLE.

1318
00:44:58,360 --> 00:44:59,440
>> IF I CHRONIC LIVER
DISEASE

1319
00:44:59,440 --> 00:45:01,680
RECOMMEND 1 THING TO TEACH ALL

1320
00:45:01,680 --> 00:45:02,880
OF OUR INVESTIGATORS WHO COME TO

1321
00:45:02,880 --> 00:45:05,680
US FOR HELP, IT'S JUST A BASIC

1322
00:45:05,680 --> 00:45:08,680
UNDERSTANDING OF REGULATORY

1323
00:45:08,680 --> 00:45:11,680
SCIENCE BECAUSE REALLY ALL OF

1324
00:45:11,680 --> 00:45:14,560
THE DECISIONS FOR TOX, FOR

1325
00:45:14,560 --> 00:45:16,640
MANUFACTURING, FOR GMP, IT'S ALL

1326
00:45:16,640 --> 00:45:18,200
GOOD JUST QUALITY ASSURANCE AND

1327
00:45:18,200 --> 00:45:20,160
REGULATORY SCIENCE AND SO, I

1328
00:45:20,160 --> 00:45:26,800
FEEL LIKE THAT WOULD BE THE

1329
00:45:26,800 --> 00:45:27,520
LOWEST COMMON DENOMINATOR AMONG

1330
00:45:27,520 --> 00:45:29,120
WHAT ALL THESE INVESTIGATORS

1331
00:45:29,120 --> 00:45:32,440
NEED TO UNDERSTAND.

1332
00:45:32,440 --> 00:45:33,760
>> AND ROSE, HOW LONG DO
YOU

1333
00:45:33,760 --> 00:45:35,240
THINK A CURRICULUM LIKE THAT

1334
00:45:35,240 --> 00:45:36,000
SHOULD LAST?

1335
00:45:36,000 --> 00:45:37,840
AND I'M ASSUMING YOU THINK THAT

1336
00:45:37,840 --> 00:45:39,800
IT COULD PROBABLY BE DONE VIA

1337
00:45:39,800 --> 00:45:42,880
WEB BASED AS OPPOSED TO HAVING

1338
00:45:42,880 --> 00:45:43,680
PHYSICALLY SHOW UP.

1339
00:45:43,680 --> 00:45:45,240
>> I THINK SO.

1340
00:45:45,240 --> 00:45:48,880
LAST YEAR, MY PROGRAM HOSTED A

1341
00:45:48,880 --> 00:45:53,560
10 PART SERIES CALLED HOW TO

1342
00:45:53,560 --> 00:45:55,480
BRING A NOVEL THERAPEUTIC FROM

1343
00:45:55,480 --> 00:45:57,960
BENCH TO BEDSIDE AND WE DID IT,

1344
00:45:57,960 --> 00:46:00,440
WE PRESENTED IT OVER 10 FRIDAYS

1345
00:46:00,440 --> 00:46:02,120
ALONG THE CRITICAL PATH STARTING

1346
00:46:02,120 --> 00:46:04,320
FROM DISCOVERY THROUGH CLINICAL,

1347
00:46:04,320 --> 00:46:05,800
YOU KNOW CLINICAL TESTING, AND

1348
00:46:05,800 --> 00:46:07,920
IT WAS WELL RECEIVED AND IT'S

1349
00:46:07,920 --> 00:46:08,880
ARCHIVED SO FOLKS CAN LOOK AT

1350
00:46:08,880 --> 00:46:09,960
IT, BUT YOU KNOW THE PROBLEM

1351
00:46:09,960 --> 00:46:12,280
THERE IS THAT IT'S NOT

1352
00:46:12,280 --> 00:46:13,360
INTERACTIVE SO YOU CAN'T ASK

1353
00:46:13,360 --> 00:46:14,760
QUESTIONS OTHER THAN WHAT THE

1354
00:46:14,760 --> 00:46:16,240
AUDIENCE HAD ASKED AND IT'S--YOU

1355
00:46:16,240 --> 00:46:19,640
KNOW IT'S NOT VERY INDEPTH, SO,

1356
00:46:19,640 --> 00:46:21,720
IT'S A STARTING POINT.

1357
00:46:21,720 --> 00:46:24,760
SIMILARLY THE BDP, THE

1358
00:46:24,760 --> 00:46:25,560
BIOPHARMACEUTICAL DEVELOPMENT

1359
00:46:25,560 --> 00:46:28,440
PROGRAM HAS AN ONLOAN GMP

1360
00:46:28,440 --> 00:46:29,160
PYOPROCESSING COURSE YOU CAN

1361
00:46:29,160 --> 00:46:30,720
TAKE AND IN FACT WHEN THEY HIRE

1362
00:46:30,720 --> 00:46:32,320
NEW STAFF, THEY HAVE TO TAKE IT

1363
00:46:32,320 --> 00:46:33,880
AND PASS IT AND I THINK THEY

1364
00:46:33,880 --> 00:46:35,840
HAVE TO RETAKE IT EVERY FEW

1365
00:46:35,840 --> 00:46:40,520
YEARS TO MAINTAIN THEIR TRAINING

1366
00:46:40,520 --> 00:46:40,880
QUALIFICATIONS.

1367
00:46:40,880 --> 00:46:43,160
SO, YOU KNOW THERE IS ONLINE

1368
00:46:43,160 --> 00:46:47,480
INFORMATION THERE FOR FOLKS WHO

1369
00:46:47,480 --> 00:46:49,240
WANT TO GET IT BUT AGAIN, IT'S

1370
00:46:49,240 --> 00:46:51,880
NOT INDIVIDUALIZED AND IT'S

1371
00:46:51,880 --> 00:46:54,080
NOT--I WOULD SAY IN THE SMALL

1372
00:46:54,080 --> 00:46:58,400
MOLECULE REALM, WE HAVE LESS

1373
00:46:58,400 --> 00:47:00,200
ONLINE INSTRUCTIONAL MATERIAL

1374
00:47:00,200 --> 00:47:04,400
THAT WE MIGHT CONSIDER PUTTING

1375
00:47:04,400 --> 00:47:06,200
OUT THERE, BUT YEAH, IT'S A

1376
00:47:06,200 --> 00:47:06,920
GREAT BEGINNING OF A

1377
00:47:06,920 --> 00:47:09,840
DISCIPLINARY CUSHION AND I

1378
00:47:09,840 --> 00:47:11,520
APPRECIATE THAT THE PRECLINICAL

1379
00:47:11,520 --> 00:47:13,360
AND IND ENABLING IS VERY

1380
00:47:13,360 --> 00:47:16,880
DIFFERENT FROM THE CLINICAL

1381
00:47:16,880 --> 00:47:18,000
APPLICATIONS AND THE TRAINING

1382
00:47:18,000 --> 00:47:25,920
NEEDS THAT NEED TO GO INTO THAT.

1383
00:47:25,920 --> 00:47:27,560
>> DR., YOUR HAND IS UP?

1384
00:47:27,560 --> 00:47:28,960
>> YES ACCIDENT I WOULD
SAY 1 OF

1385
00:47:28,960 --> 00:47:30,160
THE KNOW STRENGTHS OF MODELS

1386
00:47:30,160 --> 00:47:32,720
LIKE THE VAIL WORKSHOP IS THAT

1387
00:47:32,720 --> 00:47:34,160
IT EMBODIES SOME OF THE

1388
00:47:34,160 --> 00:47:34,880
CHARACTERISTICS OF ADULT

1389
00:47:34,880 --> 00:47:37,600
LEARNING WHICH IS THAT THE

1390
00:47:37,600 --> 00:47:40,520
ADULTS LIKE TO LEARN AROUND

1391
00:47:40,520 --> 00:47:41,720
CONCRETE PROBLEMS THAT THEY'RE

1392
00:47:41,720 --> 00:47:44,680
FACING, SO AT THE VAIL WORKSHOP,

1393
00:47:44,680 --> 00:47:46,880
YOU BRING YOUR NASCENT PROTOCOL

1394
00:47:46,880 --> 00:47:48,440
ON TO THE WORK HOP AND YOU GET

1395
00:47:48,440 --> 00:47:50,160
HELP ON IT, SOMETHING YOU'RE

1396
00:47:50,160 --> 00:47:51,320
VERY INTERESTED IN.

1397
00:47:51,320 --> 00:47:52,200
ONLINE LEARNING HAS BEEN SHOWN

1398
00:47:52,200 --> 00:47:53,720
TO BE SOMEWHAT EFFECTIVE BUT

1399
00:47:53,720 --> 00:47:55,360
DOESN'T EMBODY THE HIGHLY

1400
00:47:55,360 --> 00:47:56,080
INTERACTIVE, I'VE GOT A PROBLEM

1401
00:47:56,080 --> 00:47:57,720
I WANT TO SOLVE AND I WILL LEARN

1402
00:47:57,720 --> 00:47:59,640
HERE HOW TO DO THAT KIND OF

1403
00:47:59,640 --> 00:48:00,920
ASPECT, THAT COULD BE DELIVERED

1404
00:48:00,920 --> 00:48:03,400
OVER DISTANCES AS WELL, I'M NOT

1405
00:48:03,400 --> 00:48:05,400
SAYING IT HAS TO BE IN PERSON

1406
00:48:05,400 --> 00:48:06,960
BUT I WOULD ENCOURAGE US TO

1407
00:48:06,960 --> 00:48:07,880
THINK ABOUT APPROACHES THAT

1408
00:48:07,880 --> 00:48:09,320
ALLOW US TO BRING THEIR RESEARCH

1409
00:48:09,320 --> 00:48:10,920
PROJECT TO SUCH A DISCUSSION TO

1410
00:48:10,920 --> 00:48:13,520
SEE PERHAPS WHETHER IT HAS IP

1411
00:48:13,520 --> 00:48:19,080
LEGS, YOU KNOW CONNECTING TO

1412
00:48:19,080 --> 00:48:21,040
DR. LOWY'S CONCEPT THAT MAYBE

1413
00:48:21,040 --> 00:48:22,680
THE PROJECT ISN'T THE BEST JUDGE

1414
00:48:22,680 --> 00:48:24,640
OF IT BUT MAYBE THEY COULD BE

1415
00:48:24,640 --> 00:48:25,280
CONNECT WIDE JUDGES.

1416
00:48:25,280 --> 00:48:27,080
SO I JUST WANTED TO MAKE THAT

1417
00:48:27,080 --> 00:48:27,480
COMMENT.

1418
00:48:27,480 --> 00:48:28,240
THANKS.

1419
00:48:28,240 --> 00:48:29,880
>> SO JUST TO CLARIFY
OLIVER,

1420
00:48:29,880 --> 00:48:31,160
WHAT YOU'RE SUGGESTING IS ALMOST

1421
00:48:31,160 --> 00:48:33,840
LIKE A PRECLINICAL WORKSHOP,

1422
00:48:33,840 --> 00:48:37,320
BRING THEIR COMPOUND, OR TARGET?

1423
00:48:37,320 --> 00:48:38,280
[LAUGHTER]

1424
00:48:38,280 --> 00:48:39,160
>> LITERALLY, YES
ACCIDENT, BUT

1425
00:48:39,160 --> 00:48:43,360
BRING THE IDEA.

1426
00:48:43,360 --> 00:48:44,560
>> YEAH.

1427
00:48:44,560 --> 00:48:44,800
>> ROSE?

1428
00:48:44,800 --> 00:48:45,800
>> SIMILARLY TO GET REAL
WORLD

1429
00:48:45,800 --> 00:48:47,200
EXPERIENCE AND WE HAVE JUST

1430
00:48:47,200 --> 00:48:51,240
RECENTLY ANNOUNCE THAD WE'RE

1431
00:48:51,240 --> 00:48:52,720
RECRUITING SOME FELLOWSHIP

1432
00:48:52,720 --> 00:48:55,840
PHYSICIANS IN OUR

1433
00:48:55,840 --> 00:48:57,080
BIOPHARMACEUTICAL PLANTS, SO

1434
00:48:57,080 --> 00:48:58,480
WE'RE TRYING TO HIRE FELLOWS WHO

1435
00:48:58,480 --> 00:49:02,320
CAN COME IN FOR 2 YEARS AND

1436
00:49:02,320 --> 00:49:03,280
TRAIN IN BIOPROCESSING

1437
00:49:03,280 --> 00:49:04,680
UNDERSTANDING WHAT GOES INTO

1438
00:49:04,680 --> 00:49:05,640
REGULATORY AFFAIRS AND QUALITY

1439
00:49:05,640 --> 00:49:07,280
ASSURANCE AND EVEN THE PROCESS

1440
00:49:07,280 --> 00:49:09,240
ITSELF AND ACTUALLY THE FDA JUST

1441
00:49:09,240 --> 00:49:11,000
CONTACTED US LAST WEEK TO ASK IF

1442
00:49:11,000 --> 00:49:13,640
THEY COULD SEND NEW STAFF TO OUR

1443
00:49:13,640 --> 00:49:15,640
FACILITY TO SEE THE CELL THERAPY

1444
00:49:15,640 --> 00:49:17,880
SUITES TO SEE HOW THOSE ARE RUN

1445
00:49:17,880 --> 00:49:20,800
AND WHAT KINDS OF EQUIPMENT, BUT

1446
00:49:20,800 --> 00:49:25,960
I THINK THIS--WITH THE BIGGER--I

1447
00:49:25,960 --> 00:49:27,360
THINK THE--A BETTER WAY OR

1448
00:49:27,360 --> 00:49:28,440
SOMETHING BETTER TO MOVE TOWARD

1449
00:49:28,440 --> 00:49:29,720
IS THE TRAIN THE TRAINER IDEA.

1450
00:49:29,720 --> 00:49:32,520
SO I WOULD RATHER SEE

1451
00:49:32,520 --> 00:49:35,480
INSTITUTIONS TAKING ON THIS KIND

1452
00:49:35,480 --> 00:49:36,880
OF TRAINING INSTEAD OF HAVING

1453
00:49:36,880 --> 00:49:41,280
TO, YOU KNOW RELY ON--NOT THE

1454
00:49:41,280 --> 00:49:42,120
REMOTE, VIRTUAL TRAINING ISN'T

1455
00:49:42,120 --> 00:49:45,960
VALUABLE, BUT I THINK IT WOULD

1456
00:49:45,960 --> 00:49:48,160
BE GREAT IF THERE COULD BE SOME

1457
00:49:48,160 --> 00:49:49,640
KIND OF CO OPERATIVE EFFORT TO

1458
00:49:49,640 --> 00:49:53,760
TRAIN STAFF IN NEEZ ASPECTS OF

1459
00:49:53,760 --> 00:49:57,880
TRANSLATIONAL RESEARCH SO THAT

1460
00:49:57,880 --> 00:49:58,520
IT BECOMES SELF-PERPETUATING

1461
00:49:58,520 --> 00:50:00,040
ONSIGHT SO THAT IT'S--YOU KNOW

1462
00:50:00,040 --> 00:50:01,440
THEY BECOME MORE INDEPENDENT

1463
00:50:01,440 --> 00:50:03,960
THAT IN THAT REGARD AND THEY CAN

1464
00:50:03,960 --> 00:50:07,080
CONTINUE TO TRAIN AS NEW

1465
00:50:07,080 --> 00:50:13,120
INVESTIGATORS COME ONBOARD.

1466
00:50:13,120 --> 00:50:15,320
>> I THINK MY ONLY CONCERN
IS

1467
00:50:15,320 --> 00:50:18,760
THAT EVEN AT LIKE 1 OF THE MAJOR

1468
00:50:18,760 --> 00:50:19,440
LEADING CANCER CENTERS, THEY

1469
00:50:19,440 --> 00:50:21,800
ONLY IN THE LAST 5-60 YEARS

1470
00:50:21,800 --> 00:50:24,360
REALLY DEVELOPED A CURRICULUM

1471
00:50:24,360 --> 00:50:25,600
AROUND THIS.

1472
00:50:25,600 --> 00:50:27,120
AND IT'S THE NUMBER 1 SO I'M NOT

1473
00:50:27,120 --> 00:50:29,240
GOING TO NAME THE NAME SO THAT

1474
00:50:29,240 --> 00:50:30,640
OUGHT TO TELL YOU WHEN YOU

1475
00:50:30,640 --> 00:50:32,280
MOVE,A WAY FROM SORT OF THE

1476
00:50:32,280 --> 00:50:34,440
LEADERS, I THINK THERE'S HIEWNL

1477
00:50:34,440 --> 00:50:37,720
GIGANTIC GAPS AND EVEN AT THAT

1478
00:50:37,720 --> 00:50:39,360
MAJOR INSTITUTION, I SAW NOT

1479
00:50:39,360 --> 00:50:41,240
ONCE, NOT TWICE BUT MANY TIMES

1480
00:50:41,240 --> 00:50:42,560
WHERE YOU TELL FOLKS, OKAY,

1481
00:50:42,560 --> 00:50:44,080
BEFORE YOU GO IN THE PUBLIC

1482
00:50:44,080 --> 00:50:46,280
DOMAIN AND YOU START TALKING

1483
00:50:46,280 --> 00:50:48,360
ABOUT THIS COMPOUND OR THIS

1484
00:50:48,360 --> 00:50:51,000
STRATEGY, MAKE SURE YOU'VE GOT

1485
00:50:51,000 --> 00:50:52,520
PROVISIONAL PATENT IN HAND AND

1486
00:50:52,520 --> 00:50:54,760
IT WAS THE SAME--IT'S

1487
00:50:54,760 --> 00:50:55,560
IEE, AUDIENCERONIC, I HAVE 1

1488
00:50:55,560 --> 00:50:57,400
INVESTIGATOR WHO ACTUALLY DID IT

1489
00:50:57,400 --> 00:51:01,360
NOT ONCE BUT TWICE WHERE HE LOST

1490
00:51:01,360 --> 00:51:02,480
COMMERCIAL ABILITY BECAUSE HE

1491
00:51:02,480 --> 00:51:05,640
DIDN'T KEEP TRACK OF HIS STUDENT

1492
00:51:05,640 --> 00:51:07,000
PRESENTING AT THE AACR, AND ONCE

1493
00:51:07,000 --> 00:51:09,360
IT'S OUT IN THE PUBLIC DOMAIN,

1494
00:51:09,360 --> 00:51:13,080
IT'S GONE, SO HE--I THINK

1495
00:51:13,080 --> 00:51:14,360
THERE'S AN--AT LEAST MY

1496
00:51:14,360 --> 00:51:15,440
IMPRESSION ACROSS CANCER CENTERS

1497
00:51:15,440 --> 00:51:16,480
AND THEIR ABILITY TO DO THAT,

1498
00:51:16,480 --> 00:51:18,480
THAT WAS PART OF THE REASON WHY

1499
00:51:18,480 --> 00:51:22,880
I THOUGHT, OKAY, THIS WOULD BE A

1500
00:51:22,880 --> 00:51:24,040
POTENTIAL OPPORTUNITY FOR THE

1501
00:51:24,040 --> 00:51:26,000
NCI TO HOUSE THE SORT OF BASIC

1502
00:51:26,000 --> 00:51:26,880
KNOWLEDGE BASE GIVEN THE

1503
00:51:26,880 --> 00:51:28,280
RESOURCES AND SORT OF THE FDA

1504
00:51:28,280 --> 00:51:29,840
AND ALL OF THESE OTHER SORT OF

1505
00:51:29,840 --> 00:51:32,040
RESOURCES THAT ARE ALREADY IN

1506
00:51:32,040 --> 00:51:33,760
PLACE AND WITH THE CANCER

1507
00:51:33,760 --> 00:51:35,520
CENTERS THEN COULD USE THIS AS

1508
00:51:35,520 --> 00:51:37,360
THE FOUNDATION THEN, AS OPPOSE

1509
00:51:37,360 --> 00:51:40,360
TO EACH CANCER CENTER TRYING TO

1510
00:51:40,360 --> 00:51:44,080
DO THIS CURRICULUM, YOU KNOW IN

1511
00:51:44,080 --> 00:51:46,280
AND OF ITSELF BECAUSE I THINK

1512
00:51:46,280 --> 00:51:47,720
THE TRAINING WON'T BE UNIFORM OR

1513
00:51:47,720 --> 00:51:49,240
PER SE GREAT AT ALL.

1514
00:51:49,240 --> 00:51:55,600
SO I GUESS THAT'S JUST MY

1515
00:51:55,600 --> 00:51:56,520
THOUGHT BACK.

1516
00:51:56,520 --> 00:51:58,480
DR. BARKER?

1517
00:51:58,480 --> 00:52:00,720
>> YEAH, SO, YOU KNOW,
THAT

1518
00:52:00,720 --> 00:52:01,840
TOUCHED ON SOMETHING BEFORE THAT

1519
00:52:01,840 --> 00:52:03,200
I THINK IS REALLY IMPORTANT AND

1520
00:52:03,200 --> 00:52:05,320
THAT IS HISTORICALLY THE NIH

1521
00:52:05,320 --> 00:52:06,960
OVER AWRL AND NCI SPECIFICALLY

1522
00:52:06,960 --> 00:52:08,440
HAS FILED A LOT OF PATENTS.

1523
00:52:08,440 --> 00:52:10,600
I THINK WE STARTED REALLY

1524
00:52:10,600 --> 00:52:14,400
REVIEWING THOSE VERY EARLY, I

1525
00:52:14,400 --> 00:52:17,360
THINK AROUND 2003/4 AND SET UP A

1526
00:52:17,360 --> 00:52:18,560
PROCESS, I THINK MOST

1527
00:52:18,560 --> 00:52:19,640
UNIVERSITIES DO THAT BECAUSE YOU

1528
00:52:19,640 --> 00:52:21,160
CAN PATENT A LOT OF THINGS BUT

1529
00:52:21,160 --> 00:52:22,120
YOU DON'T NECESSARILY HAVE A

1530
00:52:22,120 --> 00:52:23,000
MARKET FOR THEM, SO YOU CAN

1531
00:52:23,000 --> 00:52:24,720
SPEND A LOT OF MONEY DEFENDING

1532
00:52:24,720 --> 00:52:28,120
YOUR PATENTS IF YOU FILE THEM.

1533
00:52:28,120 --> 00:52:29,640
ESPECIALLY IF YOU FILE THEM PC T

1534
00:52:29,640 --> 00:52:31,080
BUT I DID WANT TO BRING UP 1

1535
00:52:31,080 --> 00:52:33,160
ISSUE THAT I THINK IS CRITICALLY

1536
00:52:33,160 --> 00:52:34,480
IMPORTANT IN ALL THIS DISCUSSION

1537
00:52:34,480 --> 00:52:37,120
IS THAT MOST UNIVERSITIES DON'T

1538
00:52:37,120 --> 00:52:39,440
HAVE THE RESOURCES FOR EXAMPLE,

1539
00:52:39,440 --> 00:52:43,640
TO MAKE THEIR LABORATORIES GLP

1540
00:52:43,640 --> 00:52:44,200
COMPLIANT.

1541
00:52:44,200 --> 00:52:44,880
THEY JUST DON'T.

1542
00:52:44,880 --> 00:52:46,400
THEY CAN'T CONTROL THE FLOW, THE

1543
00:52:46,400 --> 00:52:48,640
SOPs ARE NOT WHAT THEY SHOULD

1544
00:52:48,640 --> 00:52:51,520
BE, TO PASS, YOU KNOW AN FDA

1545
00:52:51,520 --> 00:52:53,160
INSPECTION AND CERTAINLY IF YOU

1546
00:52:53,160 --> 00:52:55,680
TALK ABOUT GMP, THAT'S

1547
00:52:55,680 --> 00:52:57,640
EXTRAORDINARILY RARE BECAUSE,

1548
00:52:57,640 --> 00:52:58,920
YOU KNOW THE BAR IS VERY, VERY

1549
00:52:58,920 --> 00:53:01,560
HIGH AND SO I WANT TO BRING UP 1

1550
00:53:01,560 --> 00:53:07,360
THING IS THAT WE HAVE SENT AT

1551
00:53:07,360 --> 00:53:08,160
ASU, OCCASIONALLY, WE SEND

1552
00:53:08,160 --> 00:53:11,320
PEOPLE, A LOT OF GOOD POST DOC

1553
00:53:11,320 --> 00:53:12,600
PROGRAMS, ACTUALLY AT MERK AND

1554
00:53:12,600 --> 00:53:14,440
PFIZER AND OTHER PLACES WHERE A

1555
00:53:14,440 --> 00:53:17,200
POST DOC CAN GO THERE AND SPEND

1556
00:53:17,200 --> 00:53:19,080
2 YEARS LEARNING EVERYTHING

1557
00:53:19,080 --> 00:53:20,240
WE'RE TALKING ABOUT.

1558
00:53:20,240 --> 00:53:21,800
I'M JUST WONDER, WE'VE NEVER, I

1559
00:53:21,800 --> 00:53:23,080
DON'T KNOW, ROSE, IF WE EVER

1560
00:53:23,080 --> 00:53:25,280
THOUGHT ABOUT SETTING THAT UP

1561
00:53:25,280 --> 00:53:27,080
MORE OFFICIALLY WITH, YOU KNOW

1562
00:53:27,080 --> 00:53:29,640
NCI PLAYING SOMETHING OF A ROLE

1563
00:53:29,640 --> 00:53:31,520
YOU KNOW AS A SCREENER TO GET

1564
00:53:31,520 --> 00:53:32,720
MORE OF OUR CANCER FOLKS INTO

1565
00:53:32,720 --> 00:53:34,520
THOSE PROGRAMS THAT ARE LOOKING

1566
00:53:34,520 --> 00:53:37,920
FOR POST DOCS IN THE INDUSTRY.

1567
00:53:37,920 --> 00:53:39,200
SO THEY'RE VERY ACTIVE PROGRAMS

1568
00:53:39,200 --> 00:53:40,400
AND THEY'RE REALLY GOOD

1569
00:53:40,400 --> 00:53:42,040
ESPECIALLY, I KNOW SOMETHING

1570
00:53:42,040 --> 00:53:43,560
ABOUT THE MERK PROGRAM, AND THE

1571
00:53:43,560 --> 00:53:45,600
PFIZER PROGRAM, THEY'RE BOTH

1572
00:53:45,600 --> 00:53:46,720
REALLY GOOD.

1573
00:53:46,720 --> 00:53:47,800
SO, AND OBVIOUSLY, THEY WOULD

1574
00:53:47,800 --> 00:53:49,400
LIKE TO RECRUIT THOSE PEOPLE

1575
00:53:49,400 --> 00:53:50,600
INTO THE INDUSTRY IMMEDIATELY

1576
00:53:50,600 --> 00:53:54,920
AFTER THEY GET DONE.

1577
00:53:54,920 --> 00:53:55,360
>> EXACTLY.

1578
00:53:55,360 --> 00:53:55,680
>> EXACTLY.

1579
00:53:55,680 --> 00:53:57,560
>> BUT NO, A LOT OF THEM
COME

1580
00:53:57,560 --> 00:54:07,320
BACK TO ACADEMIA.

1581
00:54:07,320 --> 00:54:08,640
I THINK IT'S SOMETHING TO GIVE

1582
00:54:08,640 --> 00:54:10,640
BACK TO THE INDUSTRY AT LEAST. 

1583
00:54:10,640 --> 00:54:17,560
>> SOMETHING TO EXPLORE.

1584
00:54:17,560 --> 00:54:23,120
>> WELL, OKAY, SO IF
THERE'S NO

1585
00:54:23,120 --> 00:54:24,800
FURTHER COMMENT, DR. FING ERT,

1586
00:54:24,800 --> 00:54:26,760
DID YOU GET YOUR TECH IN IICAL

1587
00:54:26,760 --> 00:54:27,240
ISSUE?

1588
00:54:27,240 --> 00:54:29,040
>> I HOPE SO, IS THAT
BETTER

1589
00:54:29,040 --> 00:54:29,200
NOW.

1590
00:54:29,200 --> 00:54:30,800
>> YEAH, ACTUALLY IT IS.

1591
00:54:30,800 --> 00:54:31,160
>> FANTASTIC.

1592
00:54:31,160 --> 00:54:32,480
SO I DID SEND IN A CHAT WITH

1593
00:54:32,480 --> 00:54:36,560
WHAT I WAS TRYING TO SAY,.

1594
00:54:36,560 --> 00:54:37,200
>> OH, OKAY.

1595
00:54:37,200 --> 00:54:39,600
>> I WAS BASICALLY THE
MAJOR

1596
00:54:39,600 --> 00:54:41,600
POINT HERE IS THE, YOU KNOW WHAT

1597
00:54:41,600 --> 00:54:44,120
GETS MEASURED IS WHAT GETS DONE

1598
00:54:44,120 --> 00:54:45,440
AND I'M WONDERING IF WE SHOULD

1599
00:54:45,440 --> 00:54:48,640
KIND OF TALK ABOUT THE PROPOSED

1600
00:54:48,640 --> 00:54:51,640
MEASUREMENTS THAT DR. BOGLER AND

1601
00:54:51,640 --> 00:54:55,000
ROSE PRESENTED ABOUT YOU KNOW

1602
00:54:55,000 --> 00:55:00,440
PERFORMANCE BASED ON LIKE IRB

1603
00:55:00,440 --> 00:55:01,360
SUBMISSIONS AND ALL THAT.

1604
00:55:01,360 --> 00:55:04,760
AND ARE THERE OTHER MEASURES

1605
00:55:04,760 --> 00:55:05,720
THAT WE SHOULD CONSIDER THAT

1606
00:55:05,720 --> 00:55:10,880
MIGHT BE HELPFUL TO US GOING

1607
00:55:10,880 --> 00:55:11,280
FORWARD?

1608
00:55:11,280 --> 00:55:14,520
EXAMPLES, YOU KNOW INCLUDE, YOU

1609
00:55:14,520 --> 00:55:17,440
KNOW THE GENERATION OF

1610
00:55:17,440 --> 00:55:19,240
SUBSTANTIAL EVIDENCE, THE

1611
00:55:19,240 --> 00:55:21,880
COMPLETION OF THE TRIAL, YOU

1612
00:55:21,880 --> 00:55:23,840
KNOW BASED ON EXPECTED

1613
00:55:23,840 --> 00:55:27,600
ENROLLMENT, YOU KNOW, THINGS

1614
00:55:27,600 --> 00:55:29,680
LIKE--THINGS LIKE THAT.

1615
00:55:29,680 --> 00:55:31,440
IT'S BEEN UNFORTUNATE BUT THERE

1616
00:55:31,440 --> 00:55:34,640
HAVE BEEN NUMEROUS NCI TRIALS

1617
00:55:34,640 --> 00:55:36,920
THAT FAILED TO--NCI SPONSORED

1618
00:55:36,920 --> 00:55:40,040
TRIALS THAT SUCCEEDED TO

1619
00:55:40,040 --> 00:55:42,680
GENERATE NICE PHASE 1/2 BUT

1620
00:55:42,680 --> 00:55:43,720
MAYBE INCOMPLETE ENROLLMENT

1621
00:55:43,720 --> 00:55:49,080
ACCORDING TO THE PLAN, TO THE

1622
00:55:49,080 --> 00:55:49,960
PROTOCOL PLAN.

1623
00:55:49,960 --> 00:55:53,960
BUT, STILL GOT TO GET PUBLISHED

1624
00:55:53,960 --> 00:55:57,600
IN MAJOR JOURNALS, SO THAT IS AN

1625
00:55:57,600 --> 00:55:59,000
ACCOMPLISHMENT, JOURNAL

1626
00:55:59,000 --> 00:56:00,120
PUBLICATION, SURE, GREAT, BUT IN

1627
00:56:00,120 --> 00:56:04,120
INDUSTRY, YOU KNOW  WHERE I COME

1628
00:56:04,120 --> 00:56:05,600
FROM, WE HAVE YOU THAT WITH

1629
00:56:05,600 --> 00:56:07,040
CONCERN NOW BECAUSE THERE ARE SO

1630
00:56:07,040 --> 00:56:08,360
MANY INDUSTRY TRIALS THAT ARE

1631
00:56:08,360 --> 00:56:11,840
UNDERPOWERED AND IF ANYTHING

1632
00:56:11,840 --> 00:56:13,360
MISLEADING, AND YET, PEOPLE GET

1633
00:56:13,360 --> 00:56:14,960
GRANTS FROM THEM, SURE.

1634
00:56:14,960 --> 00:56:18,600
ARE THEY REALLY ADDING BEING

1635
00:56:18,600 --> 00:56:20,920
ABLE TO NOT ONLY JUST FILE AN

1636
00:56:20,920 --> 00:56:24,160
IND BUT ALSO THEN SUCCEED IN

1637
00:56:24,160 --> 00:56:25,800
BRINGING SOMETHING THAT'S

1638
00:56:25,800 --> 00:56:28,560
ACCESSIBLE AND COMMERCIALLY

1639
00:56:28,560 --> 00:56:31,160
PARTNERS PROPERLY TO REALLY HAVE

1640
00:56:31,160 --> 00:56:34,240
IMPACT ON PATIENT CARE.

1641
00:56:34,240 --> 00:56:34,560
>> YEAH.

1642
00:56:34,560 --> 00:56:39,840
YOUR POINT'S WELL TAKEN DR. FING

1643
00:56:39,840 --> 00:56:43,320
ERT, I THINK THE METRICS ARE

1644
00:56:43,320 --> 00:56:45,400
WHERE THEY A--BITS LIEN AND IF

1645
00:56:45,400 --> 00:56:46,680
SOMEONE'S IN THE PIPELINE, I'M

1646
00:56:46,680 --> 00:56:48,120
SURE YOU WOULD AGREE, DO YOU

1647
00:56:48,120 --> 00:56:49,360
HAVE THE MECHANISM WORKED OUT,

1648
00:56:49,360 --> 00:56:53,120
YOU KNOW WHAT IS THE OFF TARGET

1649
00:56:53,120 --> 00:56:54,320
EFFECT OF WHATEVER YOU'RE

1650
00:56:54,320 --> 00:56:55,360
WORKING ON, THE METRICS FOR

1651
00:56:55,360 --> 00:56:56,840
SOMETHING LIKE THAT WOULD BE

1652
00:56:56,840 --> 00:56:58,760
MUCH DIFFERENT AS OPPOSED TO

1653
00:56:58,760 --> 00:57:00,360
MUCH LATER STAGE CLINICAL TRIALS

1654
00:57:00,360 --> 00:57:02,240
BUT YOUR POINTS ARE VERY WELL

1655
00:57:02,240 --> 00:57:03,400
TAKEN, THANK YOU.

1656
00:57:03,400 --> 00:57:04,040
>> YEAH, THE OTHER POINT I

1657
00:57:04,040 --> 00:57:07,360
BROUGHT UP IS THAT THE IDEA OF

1658
00:57:07,360 --> 00:57:08,320
EXPERTISE AND BRINGING IN

1659
00:57:08,320 --> 00:57:09,880
EXPERTISE IS SOMETHING I WORKED

1660
00:57:09,880 --> 00:57:12,640
WITH IN ACADEMIA, I WAS AT

1661
00:57:12,640 --> 00:57:13,320
HARVARD FACULTY AND INDUSTRY AND

1662
00:57:13,320 --> 00:57:15,240
I THINK WE HAVE TO APPRECIATION

1663
00:57:15,240 --> 00:57:19,240
THAT THAT'S NOT A STATIC THING

1664
00:57:19,240 --> 00:57:20,760
THAT JUST HAPPENS, YOU BRING IN

1665
00:57:20,760 --> 00:57:23,760
1 EXPERT, YOU KNOW IT REQUIRES

1666
00:57:23,760 --> 00:57:28,120
THIS SYSTEMATIC THINKING ABOUT

1667
00:57:28,120 --> 00:57:29,920
HOW TO GET--LET THE EXPERT HAVE

1668
00:57:29,920 --> 00:57:31,440
DEEP LEARNING AS THEY GO ON AND

1669
00:57:31,440 --> 00:57:32,800
THEN THE AUDIENCE AND THE

1670
00:57:32,800 --> 00:57:35,040
PROGRAM STAFF HAVING DEEP

1671
00:57:35,040 --> 00:57:38,000
LEARNING INCLUDING LEARNING FROM

1672
00:57:38,000 --> 00:57:38,520
FAILURES.

1673
00:57:38,520 --> 00:57:40,280
YOU KNOW WE'RE QUITE GOOD AT

1674
00:57:40,280 --> 00:57:44,000
HEARING FROM PROGRAM STAFF ABOUT

1675
00:57:44,000 --> 00:57:46,080
SUCCESSES, THE SBIR PHASE 2

1676
00:57:46,080 --> 00:57:48,160
SUCCESSES, WE DON'T REALLY HEAR

1677
00:57:48,160 --> 00:57:49,640
ABOUT THE FAILURES, YOU KNOW AND

1678
00:57:49,640 --> 00:57:53,480
WHAT HAVE WE LEARNED FROM THE

1679
00:57:53,480 --> 00:57:54,000
FAILURES GOING FORWARD.

1680
00:57:54,000 --> 00:57:57,520
MAYBE THAT HAS TO BE A PRIVATE

1681
00:57:57,520 --> 00:57:58,720
DISCUSSION BECAUSE IT'S

1682
00:57:58,720 --> 00:58:00,000
PROBLEMATIC SENSITIVE BECAUSE

1683
00:58:00,000 --> 00:58:01,120
THAT'S REALLY WHERE YOU LEARN

1684
00:58:01,120 --> 00:58:04,400
AND WHEN I GREW UP IN ACADEMIA,

1685
00:58:04,400 --> 00:58:06,440
WE HAD CPCs, CLINICAL

1686
00:58:06,440 --> 00:58:08,160
PATHOLOGIC CONFERENCES WHERE THE

1687
00:58:08,160 --> 00:58:09,080
PATHOLOGIST CAME IN AND WENT

1688
00:58:09,080 --> 00:58:11,920
OVER WHAT THE TRUTH WAS FROM

1689
00:58:11,920 --> 00:58:13,120
SOME OF YOU ARE NODDING BECAUSE

1690
00:58:13,120 --> 00:58:14,560
YOU KNOW WHAT I'M TALKING ABOUT,

1691
00:58:14,560 --> 00:58:16,400
THOSE WERE HUGE LEARNING

1692
00:58:16,400 --> 00:58:17,520
EXPERIENCES AND VERY POPULAR AND

1693
00:58:17,520 --> 00:58:19,240
THEY'RE PART OF NEW ENGLAND

1694
00:58:19,240 --> 00:58:21,640
JOURNAL NOW INTEGRATED INTO IT,

1695
00:58:21,640 --> 00:58:23,240
AND THAT'S WHAT I'M THINKING

1696
00:58:23,240 --> 00:58:24,640
ABOUT, YOU KNOW LEARNING FROM

1697
00:58:24,640 --> 00:58:26,880
THE FAILURES AND PIT FALLS,

1698
00:58:26,880 --> 00:58:28,520
THATIA A CULTURE CHANGE.

1699
00:58:28,520 --> 00:58:31,160
>> YEAH, THAT COULD
OBVIOUSLY BE

1700
00:58:31,160 --> 00:58:32,120
INCLUDE AS PART OF THE

1701
00:58:32,120 --> 00:58:32,960
CURRICULUM, AS WELL AS PEOPLE

1702
00:58:32,960 --> 00:58:34,080
FROM THE BUSINESS SIDE, AS WELL

1703
00:58:34,080 --> 00:58:35,840
AS LAWYERS WHEN YOU START

1704
00:58:35,840 --> 00:58:36,680
TALKING ABOUT INTELLECTUAL

1705
00:58:36,680 --> 00:58:38,800
PROPERTY, THAT KIND OF THING AS

1706
00:58:38,800 --> 00:58:39,560
WELL.

1707
00:58:39,560 --> 00:58:40,240
DULY NOTED.

1708
00:58:40,240 --> 00:58:40,560
>> RIGHT.

1709
00:58:40,560 --> 00:58:41,240
>> OKAY, PAULET, I
BUILDING

1710
00:58:41,240 --> 00:58:42,880
WE'RE RIGHT AT THE TOP OF THE

1711
00:58:42,880 --> 00:58:44,080
HOUR, I BELIEVE THE SECOND

1712
00:58:44,080 --> 00:58:45,800
COMMITTEE NEEDS TO GET UNDERWAY,

1713
00:58:45,800 --> 00:58:47,720
I THANK EVERYONE FOR THEIR VERY

1714
00:58:47,720 --> 00:58:49,480
KIND ATTENTION AND I WILL TURN

1715
00:58:49,480 --> 00:58:59,880
THIS BACK OVER TO PAULET.

1716
00:58:59,880 --> 00:59:00,960
>> THANKS, AMY, FOR THE

1717
00:59:00,960 --> 00:59:01,560
SUBCOMMITTEDEE MEETING AND I

1718
00:59:01,560 --> 00:59:03,960
WILL TURN IT BACK OVER TO JOYCE

1719
00:59:03,960 --> 00:59:05,680
AS SHE IS HELPING WITH THE

1720
00:59:05,680 --> 00:59:10,360
SUBCOMMITTEE MEETINGS FOR ME. 

1721
00:59:10,360 --> 00:59:19,400
>> THANK YOU ALL.

1722
00:59:19,400 --> 00:59:21,640
>>WE HAVE TO RUN THE NCI
WITH

1723
00:59:21,640 --> 00:59:25,240
THE RESOURCES WE GOT FROM WITHIN

1724
00:59:25,240 --> 00:59:26,200
GOVERNMENT AND WE HAVE SPLG TO

1725
00:59:26,200 --> 00:59:27,960
DO WITH THAT HOPEFULLY.

1726
00:59:27,960 --> 00:59:31,480
FIRST OF ALL WELCOME PATRICK

1727
00:59:31,480 --> 00:59:32,000
Mc GARY OUR EXECUTIVE

1728
00:59:32,000 --> 00:59:35,240
SECRETARY WHO WILL DO MOST OF

1729
00:59:35,240 --> 00:59:36,640
THE TALKING TODAY.

1730
00:59:36,640 --> 00:59:38,240
IT'S--JUST A LINGS BIT OF

1731
00:59:38,240 --> 00:59:40,080
BACKGROUND, YOU KNOW IT'S--I'VE

1732
00:59:40,080 --> 00:59:41,760
BEEN AROUND FOR A LONG TIME AND

1733
00:59:41,760 --> 00:59:44,240
IT'S A REALLY INTERESTING TIME I

1734
00:59:44,240 --> 00:59:45,400
THINK IN NCI'S HISTORY.

1735
00:59:45,400 --> 00:59:48,600
I MEAN 1 WE JUST HAD THE 50th

1736
00:59:48,600 --> 00:59:50,560
ANNIVERSARY LAST YEAR, BUT I

1737
00:59:50,560 --> 00:59:51,840
CAN'T RECALL A TIME EVEN WITH

1738
00:59:51,840 --> 00:59:54,880
THE DOUBLING OF THE NIH BUDGET,

1739
00:59:54,880 --> 00:59:56,360
YOU KNOW, WHICH WAS A LONG TIME

1740
00:59:56,360 --> 00:59:58,560
AGO NOW, BUT WHEN WE'VE HAD THIS

1741
00:59:58,560 --> 01:00:05,400
MANY APPLICATIONS COMING IN TO

1742
01:00:05,400 --> 01:00:07,040
NCI VERSUS THE OTHER INSTITUTES,

1743
01:00:07,040 --> 01:00:08,680
AND THE EXTENT TO WHICH IT'S

1744
01:00:08,680 --> 01:00:09,920
REALLY AFFECTING THE PAY LINES

1745
01:00:09,920 --> 01:00:11,280
AND CONTINUES TO AFFECT THE PAY

1746
01:00:11,280 --> 01:00:11,800
LINES.

1747
01:00:11,800 --> 01:00:13,600
SO YOU KNOW IT REALLY SPEAKS TO,

1748
01:00:13,600 --> 01:00:15,080
THOUGH, I THINK THE AMOUNT OF

1749
01:00:15,080 --> 01:00:16,400
PROGRESS THAT WE'RE MAKING IN

1750
01:00:16,400 --> 01:00:17,280
CONSCIENCER RESEARCH, AND SO I

1751
01:00:17,280 --> 01:00:19,400
THINK WE HAVE TO DO EVERYTHING

1752
01:00:19,400 --> 01:00:21,320
POSSIBLE TO HELP TO PROTECT THIS

1753
01:00:21,320 --> 01:00:25,320
BUDGET, CERTAINLY AT THIS TIME,

1754
01:00:25,320 --> 01:00:26,160
BECAUSE THERE'S--I KNOW WE SAY

1755
01:00:26,160 --> 01:00:29,520
THIS ALL THE TIME BUT I--I THINK

1756
01:00:29,520 --> 01:00:31,400
THIS WHOLE CONCEPT OF PRECISION

1757
01:00:31,400 --> 01:00:33,320
MEDICINE IS REALLY TAKING OFF

1758
01:00:33,320 --> 01:00:35,240
AND MUCH OF WHAT WE HAVE

1759
01:00:35,240 --> 01:00:37,200
SUPPORTED AT NCI THROUGH THE

1760
01:00:37,200 --> 01:00:39,920
YEARS HAS ENABLED US TO GET HERE

1761
01:00:39,920 --> 01:00:41,720
AND WHY HAVE A LOT OF ENERGIZED

1762
01:00:41,720 --> 01:00:43,200
PEOPLE OUT THERE WHO REALLY WANT

1763
01:00:43,200 --> 01:00:46,440
TO APPLY FOR GRANTS, RO-1 GRANTS

1764
01:00:46,440 --> 01:00:49,320
THROUGH OUR RFAs, OTHER WAYS,

1765
01:00:49,320 --> 01:00:51,960
SO, THERE'S A LOT GOING ON RIGHT

1766
01:00:51,960 --> 01:00:54,200
NOW, RELATIVE TO I THINK--I

1767
01:00:54,200 --> 01:00:55,560
THINK THE SENATE AND THE HOUSE

1768
01:00:55,560 --> 01:00:58,720
BOTH WANT TO PUT MORE RESOURCES

1769
01:00:58,720 --> 01:01:00,360
IN NCI, SO YOU WILL SEE THAT IN

1770
01:01:00,360 --> 01:01:04,120
THE BUDGETS AND YOU WILL SEE

1771
01:01:04,120 --> 01:01:06,640
THIS YING AND YANG WHICH PATRICK

1772
01:01:06,640 --> 01:01:08,120
WILL TALK ABOUT BETWEEN THE

1773
01:01:08,120 --> 01:01:09,200
WHITE HOUSE AND THE SENATE AND

1774
01:01:09,200 --> 01:01:11,080
HE WILL TELL YOU A LITTLE BIT

1775
01:01:11,080 --> 01:01:14,480
ABOUT THE ORIGINAL BUDGET WE HAD

1776
01:01:14,480 --> 01:01:15,680
YOU KNOW FOR 2023 IS NOT QUITE

1777
01:01:15,680 --> 01:01:17,920
WHAT IT SEEMED TO BE INITIALLY.

1778
01:01:17,920 --> 01:01:20,840
IT LOOKED LIKE A SIGNIFICANT

1779
01:01:20,840 --> 01:01:22,480
DECREASE IN THE NCI'S BUDGET BUT

1780
01:01:22,480 --> 01:01:23,480
THAT'S NOT THE CASE.

1781
01:01:23,480 --> 01:01:27,680
BUT WE ARE FACING IN 2023 THE

1782
01:01:27,680 --> 01:01:30,960
LAST YEAR OF OUR FUNDING FOR THE

1783
01:01:30,960 --> 01:01:31,240
MOON SHOT.

1784
01:01:31,240 --> 01:01:32,320
THAT'S A BIG DEAL.

1785
01:01:32,320 --> 01:01:35,600
THAT'S A LOT OF MONEY.

1786
01:01:35,600 --> 01:01:36,720
AND WE'RE HOPEFUL THAT CONGRESS

1787
01:01:36,720 --> 01:01:38,440
IS GOING TO LOOK AT THAT AND

1788
01:01:38,440 --> 01:01:40,560
SAY, YOU KNOW WE JUST CAN'T HAVE

1789
01:01:40,560 --> 01:01:42,280
THAT HAPPEN, NOT AT A TIME WHEN

1790
01:01:42,280 --> 01:01:43,520
WE'RE GETTING THIS KIND OF

1791
01:01:43,520 --> 01:01:45,560
RESPONSE FROM THE EXTRAMURAL

1792
01:01:45,560 --> 01:01:50,760
COMMUNITY IN TERMS OF IDEAS.

1793
01:01:50,760 --> 01:01:52,880
SO, THE 2023 BUDGET PROCESS IS

1794
01:01:52,880 --> 01:01:55,160
UNDER WAY, STARTED WITH THE

1795
01:01:55,160 --> 01:01:57,080
HOUSE IN JUNE, AND JUST THIS

1796
01:01:57,080 --> 01:01:58,920
WEEK, THINGS ARE GOING ON

1797
01:01:58,920 --> 01:02:02,520
ACTUALLY ON THE SENATE SIDE, SO,

1798
01:02:02,520 --> 01:02:04,600
IT'S LOOKING GOOD, I THINK FOR

1799
01:02:04,600 --> 01:02:07,800
NIH AND I THINK BETTER FOR NCI,

1800
01:02:07,800 --> 01:02:09,080
BUT I DON'T THINK PERSONALLY

1801
01:02:09,080 --> 01:02:12,880
IT'S WHAT IT NEEDS TO BE.

1802
01:02:12,880 --> 01:02:17,400
SO PATRICK WILL TALK MORE ABOUT

1803
01:02:17,400 --> 01:02:19,520
THE SPECIFICS HERE, BUT I'M--I'M

1804
01:02:19,520 --> 01:02:21,360
FRANKLY A LITTLE CONCERNED

1805
01:02:21,360 --> 01:02:28,160
BECAUSE AS I LOOK FORWARD THE

1806
01:02:28,160 --> 01:02:29,520
PRESIDENT'S MOON SHOT 2.0, TO

1807
01:02:29,520 --> 01:02:31,680
THIS POINT WE HAVEN'T SEEN A LOT

1808
01:02:31,680 --> 01:02:33,600
OF NEW MONEY REALLY VENTURE

1809
01:02:33,600 --> 01:02:35,360
TOWARD THE NCI.

1810
01:02:35,360 --> 01:02:38,040
SO, RELATIVE TO THE LAST

1811
01:02:38,040 --> 01:02:40,400
SUBCOMMITTEE MEETING WHICH

1812
01:02:40,400 --> 01:02:43,480
DR. HEIMBERGER REALLY JUST

1813
01:02:43,480 --> 01:02:44,840
FINISHED, I'M WONDERING ABOUT

1814
01:02:44,840 --> 01:02:47,600
THE ROLE OF ARP A-H NOW AND

1815
01:02:47,600 --> 01:02:48,600
STARTING TO THINK ABOUT SOME OF

1816
01:02:48,600 --> 01:02:51,680
THE THINGS WE JUST TALKED ABOUT

1817
01:02:51,680 --> 01:02:54,040
IN THAT SUBCOMMITTEE FOR

1818
01:02:54,040 --> 01:02:55,640
EXPERIMENTAL THERAPEUTICS IF ARP

1819
01:02:55,640 --> 01:02:58,120
A H MIGHT BE 1 OF THOSE VEHICLES

1820
01:02:58,120 --> 01:02:59,840
THAT WE COULD ACTUALLY SEE

1821
01:02:59,840 --> 01:03:01,040
ACCEPT INTO THIS SPACE AND DO

1822
01:03:01,040 --> 01:03:03,680
MORE IN TERMS OF FUNDING SOME OF

1823
01:03:03,680 --> 01:03:04,720
THE PRECLENICAL ESPECIALLY

1824
01:03:04,720 --> 01:03:06,040
MAYBE, AND EVEN EARLY

1825
01:03:06,040 --> 01:03:08,840
TRANSLATIONAL WORK FOR PEOPLE

1826
01:03:08,840 --> 01:03:10,400
WHO WANT TO TAKE THEIR GOOD

1827
01:03:10,400 --> 01:03:12,560
IDEAS WHICH ARE PROTECTED

1828
01:03:12,560 --> 01:03:13,000
FORWARD.

1829
01:03:13,000 --> 01:03:15,360
SO ARP A H, IS ALSO KIND OF BACK

1830
01:03:15,360 --> 01:03:16,640
AND FORTH BETWEEN THE SENATE AND

1831
01:03:16,640 --> 01:03:20,520
THE HOUSE AND THE WHITE HOUSE.

1832
01:03:20,520 --> 01:03:21,960
SO THERE IS AN ONGOING

1833
01:03:21,960 --> 01:03:22,760
CONVERSATION ABOUT WHETHER OR

1834
01:03:22,760 --> 01:03:24,160
NOT IT SHOULD BE WITHIN NIH

1835
01:03:24,160 --> 01:03:27,160
WHICH IS WHAT THE PRESIDENT

1836
01:03:27,160 --> 01:03:29,240
WOULD LIKE AND/OR IT SHOULD BE

1837
01:03:29,240 --> 01:03:31,680
OUTSIDE THE NIH COMPLETELY.

1838
01:03:31,680 --> 01:03:34,080
IF IT'S IN THE NIH, THE WHYS

1839
01:03:34,080 --> 01:03:36,400
HOUSE SAID IT COULD CERTAINLY BE

1840
01:03:36,400 --> 01:03:37,320
OUTSIDE OF WASHINGTON BUT I

1841
01:03:37,320 --> 01:03:39,080
THINK THE PRESIDENT WANTS TO

1842
01:03:39,080 --> 01:03:43,000
MAKE SURE THAT THAT WHICH IS

1843
01:03:43,000 --> 01:03:44,680
AVAILABLE IN TERMS OF RESOURCES

1844
01:03:44,680 --> 01:03:46,960
TO THE NIH ARE AVAILABLE TO ARP

1845
01:03:46,960 --> 01:03:47,200
A H.

1846
01:03:47,200 --> 01:03:51,720
AND THE OTHER SIDE OF THAT

1847
01:03:51,720 --> 01:03:52,560
CONSTANT ISSUE ACTUALLY, HER

1848
01:03:52,560 --> 01:03:56,520
COLLEAGUES WOULD LIKE TO SEE IT

1849
01:03:56,520 --> 01:03:57,720
OUT OF NIH, THAT THEY'RE

1850
01:03:57,720 --> 01:04:01,040
THINKING IS IT WOULD BE A MORE

1851
01:04:01,040 --> 01:04:04,120
CREATIVE, A FASTER AND MORE

1852
01:04:04,120 --> 01:04:04,560
NIMBLE AGENCY.

1853
01:04:04,560 --> 01:04:06,520
ALL OF THAT IS STILL UNDER

1854
01:04:06,520 --> 01:04:07,520
DISCUSSION AND PATRICK WILL ALSO

1855
01:04:07,520 --> 01:04:08,840
TALK A LITTLE BIT ABOUT THAT BUT

1856
01:04:08,840 --> 01:04:10,480
YOU KNOW THEREYA A LOT OF MONEY

1857
01:04:10,480 --> 01:04:13,880
HERE THAT'S GOING TO BE GOING

1858
01:04:13,880 --> 01:04:17,880
INTO A WHOLE NEW SORT OF I THINK

1859
01:04:17,880 --> 01:04:19,080
CONSTRUCT FOR HOW WE CAN SUPPORT

1860
01:04:19,080 --> 01:04:20,160
RESEARCH AND I THINK CANCER

1861
01:04:20,160 --> 01:04:23,280
SHOULD FIGURE OUT WAYS TO TAKE

1862
01:04:23,280 --> 01:04:27,320
ADVANTAGE OF THAT.

1863
01:04:27,320 --> 01:04:29,840
SO--SO, I ACTUALLY, I'VE GOTTEN

1864
01:04:29,840 --> 01:04:30,920
SOME QUESTIONS IN THE LAST FEW

1865
01:04:30,920 --> 01:04:32,360
WEEKS FROM A COUPLE OF YOU THAT

1866
01:04:32,360 --> 01:04:37,360
WE CAN TAKE UP AT THE END OF OUR

1867
01:04:37,360 --> 01:04:38,640
COMMITTEE MEETING TODAY AND WE

1868
01:04:38,640 --> 01:04:40,880
CAN MAYBE ASK PATRICK'S ADVICE

1869
01:04:40,880 --> 01:04:42,920
ON HOW WE MIGHT ANSWER THESE.

1870
01:04:42,920 --> 01:04:44,440
SO PATRICK WHY DON'T I INTRODUCE

1871
01:04:44,440 --> 01:04:45,600
YOU AND TAKE US THROUGH WHAT YOU

1872
01:04:45,600 --> 01:04:49,200
KNOW AND WHAT YOU DON'T KNOW

1873
01:04:49,200 --> 01:04:52,120
ABOUT 2022, WE KNOW SOMETHING

1874
01:04:52,120 --> 01:04:53,480
ABOUT 2023, I GUESS WE WILL

1875
01:04:53,480 --> 01:04:55,120
SPECULATE A BIT BUT WE KNOW A

1876
01:04:55,120 --> 01:05:00,800
FEW THINGS, SO PATRICK, TAKE IT

1877
01:05:00,800 --> 01:05:01,000
AWAY.

1878
01:05:01,000 --> 01:05:04,200
>> THOWCH ANN, IT'S GOOD
TO BE

1879
01:05:04,200 --> 01:05:05,880
WITH YOU AGAIN, DR. BARKER AND

1880
01:05:05,880 --> 01:05:07,840
THE OTHER MEMBERS OF THE

1881
01:05:07,840 --> 01:05:08,200
SUBCOMMITTEE.

1882
01:05:08,200 --> 01:05:11,480
CAN WE BRING UP THE SLIDES?

1883
01:05:11,480 --> 01:05:11,680
YEAH.

1884
01:05:11,680 --> 01:05:12,160
APPRECIATE IT.

1885
01:05:12,160 --> 01:05:15,360
YEAH, SO WE CAN MOVE ON TO THE

1886
01:05:15,360 --> 01:05:16,960
NEXT SLIDE, PLEASE.

1887
01:05:16,960 --> 01:05:19,000
SO THIS IS THE AGENDA SLIDE FOR

1888
01:05:19,000 --> 01:05:20,520
TODAY'S MEETING, I WILL RUN

1889
01:05:20,520 --> 01:05:21,920
THROUGH 3 FISCAL YEARS,

1890
01:05:21,920 --> 01:05:25,120
BEGINNING WITH OUR CURRENT YEAR

1891
01:05:25,120 --> 01:05:26,760
FY2022, I DON'T THINK IT WILL

1892
01:05:26,760 --> 01:05:29,840
SURPRISE YOU THAT CLARITY ABOUT

1893
01:05:29,840 --> 01:05:32,840
THE 3 FISCAL YEARS IS MORE AND

1894
01:05:32,840 --> 01:05:34,800
MORE CERTAIN AT THE CURRENT YEAR

1895
01:05:34,800 --> 01:05:36,360
WHICH IS RAPIDLY COMING TO A

1896
01:05:36,360 --> 01:05:39,760
CLOSE AS OF THE END OF SEPTEMBER

1897
01:05:39,760 --> 01:05:44,120
JUST A MONTH AWAY, CONGRESS

1898
01:05:44,120 --> 01:05:46,160
CONTINUES TO DELIBERATE ON FY20

1899
01:05:46,160 --> 01:05:48,920
TWA AS I WILL DISCUSS WHILE AT

1900
01:05:48,920 --> 01:05:50,560
THE SAME TIME THE ADMINISTRATION

1901
01:05:50,560 --> 01:05:55,520
BEGUNS TO FORMULATE THE FY2024

1902
01:05:55,520 --> 01:05:55,760
BUDGET.

1903
01:05:55,760 --> 01:05:58,280
THE ADMINISTRATION WON'T DELIVER

1904
01:05:58,280 --> 01:06:01,760
THAT BUDGET FOR FY2024 TO

1905
01:06:01,760 --> 01:06:04,440
CONGRESS UNTIL 7-8 MONTHS FROM

1906
01:06:04,440 --> 01:06:04,760
NOW.

1907
01:06:04,760 --> 01:06:07,360
SO WE HAVE 1 THAT'S COMING TO A

1908
01:06:07,360 --> 01:06:10,120
CLOSE, 1 THAT WE'RE WATCHING

1909
01:06:10,120 --> 01:06:11,840
EVENTS UNFOLD IN CONGRESS AND 1

1910
01:06:11,840 --> 01:06:13,400
WHERE WE'RE WATCHING EVENTS

1911
01:06:13,400 --> 01:06:15,080
UNFOLD WITHIN THE ADMINISTRATION

1912
01:06:15,080 --> 01:06:21,400
WHICH WILL EVENTUALLY TAKE SHAPE

1913
01:06:21,400 --> 01:06:22,360
FURTHER IN CONGRESS.

1914
01:06:22,360 --> 01:06:26,800
AND THAT'S WHEN WE'LL KNOW THE

1915
01:06:26,800 --> 01:06:29,400
SCOPE OF NCI PROGRAMS IN

1916
01:06:29,400 --> 01:06:31,480
PRESIDENT BIDEN'S SUPER CHARGED

1917
01:06:31,480 --> 01:06:33,840
MOON SHOT THAT HE ANNOUNCED THIS

1918
01:06:33,840 --> 01:06:34,880
PAST FEBRUARY.

1919
01:06:34,880 --> 01:06:41,560
SO, NEXT SLIDE, PLEASE.

1920
01:06:41,560 --> 01:06:44,400
SO WHAT YOU SEE ON THE SLIDE IS

1921
01:06:44,400 --> 01:06:47,000
THE CLASSIC WAY NCI HAS

1922
01:06:47,000 --> 01:06:47,680
PRESENTED OUR APPROPRIATED

1923
01:06:47,680 --> 01:06:50,560
BUDGET ACROSS THE YEARS IN

1924
01:06:50,560 --> 01:06:52,720
MARCH, IT'S A COMPARISON, SO CAN

1925
01:06:52,720 --> 01:06:55,800
YOU WATCH THE GROWTH AND CHANGES

1926
01:06:55,800 --> 01:06:58,680
AND IN MARCH, THE PRESIDENT

1927
01:06:58,680 --> 01:07:00,360
SIGNED THE OMNIBUS

1928
01:07:00,360 --> 01:07:00,920
APPROPRIATIONS.

1929
01:07:00,920 --> 01:07:04,640
AS YOU CAN SEE ON THE FAR RIGHT

1930
01:07:04,640 --> 01:07:07,160
NCI TOTAL APPROPRIATION IS JUST

1931
01:07:07,160 --> 01:07:10,800
SHY OF 7 BILLION AND THAT

1932
01:07:10,800 --> 01:07:12,200
INCLUDES 3 COMPONENTS,

1933
01:07:12,200 --> 01:07:14,600
APPROXIMATELY 6.7 IS OUR BASE,

1934
01:07:14,600 --> 01:07:19,480
THE LARGE BLUE SECTION OF THE

1935
01:07:19,480 --> 01:07:22,720
GRAPH, COLUMN, AND ADDED TO THAT

1936
01:07:22,720 --> 01:07:24,040
BASE IS $50 MILLION, ACTUALLY

1937
01:07:24,040 --> 01:07:25,680
IT'S INCLUDED WITHIN THE BASE

1938
01:07:25,680 --> 01:07:28,680
TECHNICALLY BUT FORGET ABOUT THE

1939
01:07:28,680 --> 01:07:31,040
TECHNICALITYS, $50 MILLION FOR

1940
01:07:31,040 --> 01:07:32,640
THE CHILDHOOD CANCER INITIATIVE,

1941
01:07:32,640 --> 01:07:36,440
SHOWN IN GREEN AND THEN FURTHER

1942
01:07:36,440 --> 01:07:39,600
ADDED IS MOON SHOT, NCI'S BASED

1943
01:07:39,600 --> 01:07:45,320
APPROPRIATION GETS AN ADDITIONAL

1944
01:07:45,320 --> 01:07:46,960
194 MILLION IN FY2022 FOR THE

1945
01:07:46,960 --> 01:07:50,760
CANCER MOONSHOT AND THAT ALL

1946
01:07:50,760 --> 01:07:51,600
APPEARS IN ORANGE.

1947
01:07:51,600 --> 01:07:57,080
THAT TOTAL, ON THE FAR RIGHT

1948
01:07:57,080 --> 01:08:00,600
COLUMN IS 353 MILLION INCREASE

1949
01:08:00,600 --> 01:08:06,320
OVER FY2021 WHICH IS AN

1950
01:08:06,320 --> 01:08:07,320
ADDITIONAL 5.4%.

1951
01:08:07,320 --> 01:08:09,880
AS DR. BARKER HAS ALREADY TOLD

1952
01:08:09,880 --> 01:08:13,560
US, FY2022 IS THE SIXTH OF 7

1953
01:08:13,560 --> 01:08:15,160
YEARS OF CANCER MOONSHOT.

1954
01:08:15,160 --> 01:08:20,160
THEY LAUNCHED IT BACK IN 2017

1955
01:08:20,160 --> 01:08:24,160
AND LET'S MOVE ON TO THE NEXT

1956
01:08:24,160 --> 01:08:24,960
SLIDE, PLEASE.

1957
01:08:24,960 --> 01:08:26,280
SO I'M REPRISING THIS, THIS IS

1958
01:08:26,280 --> 01:08:29,040
SOMETHING I SHOWED IN JUNE AND

1959
01:08:29,040 --> 01:08:32,360
I'M DISPLAYING THE GRAPHIC THAT

1960
01:08:32,360 --> 01:08:34,120
AWLINGS APPEARED IN THE--ALSO

1961
01:08:34,120 --> 01:08:36,200
APPEARED IN THE APRIL 1st

1962
01:08:36,200 --> 01:08:37,920
BOTTOM LINE POST AND THE TABLE

1963
01:08:37,920 --> 01:08:40,080
JUST DISPLAYS THE PROMINENT NCI

1964
01:08:40,080 --> 01:08:42,920
GRANT FUNDING POLICIES FOR THE

1965
01:08:42,920 --> 01:08:46,880
CURRENT FISCAL YEAR FY2022.

1966
01:08:46,880 --> 01:08:48,960
AT THE VERY BOTTOM, YOU CAN SEE

1967
01:08:48,960 --> 01:08:52,840
A LINK THERE FOR THE FULL

1968
01:08:52,840 --> 01:08:53,800
FUNDING POLICIES FOR

1969
01:08:53,800 --> 01:08:56,000
SUBMECHANISMS OTHER THAN WHAT

1970
01:08:56,000 --> 01:08:57,160
WE'RE TALKING ABOUT HERE.

1971
01:08:57,160 --> 01:09:01,600
SO THE 3 GRANT POLICIES

1972
01:09:01,600 --> 01:09:03,680
R--EXCUSE ME R01S, THEY'RE

1973
01:09:03,680 --> 01:09:05,640
FUNDED AT THE 11th PERCENTILE,

1974
01:09:05,640 --> 01:09:08,480
ESIs ARE AT THE 16th

1975
01:09:08,480 --> 01:09:11,640
PERCENTILE, AND RO-1S ARE AT THE

1976
01:09:11,640 --> 01:09:13,080
11 AND THOSE ARE THE SAME

1977
01:09:13,080 --> 01:09:22,440
POLICIES WE HAD IN THE PRIOR

1978
01:09:22,440 --> 01:09:24,040
YEAR FY2020-2021, WE HAD TO MAKE

1979
01:09:24,040 --> 01:09:26,440
SURE WE COULD PAY ALL THESE NEW

1980
01:09:26,440 --> 01:09:26,720
GRANTS.

1981
01:09:26,720 --> 01:09:29,920
WE MAKE THIS COMMITMENT TO A PAY

1982
01:09:29,920 --> 01:09:31,320
LINE, YOU KNOW AS EARLY AS

1983
01:09:31,320 --> 01:09:32,080
POSSIBLE IN THE FISCAL YEAR BUT

1984
01:09:32,080 --> 01:09:34,000
WE NEED TO BE SURE WE CAN AFFORD

1985
01:09:34,000 --> 01:09:38,240
ALL THAT, WE NEEDED TO TAKE A 2%

1986
01:09:38,240 --> 01:09:42,480
REDUCTION, THAT IS TO PAY

1987
01:09:42,480 --> 01:09:43,200
NONCOMPETING GRANTS AT 98%,

1988
01:09:43,200 --> 01:09:44,840
HOWEVER, THERE ARE A FEW

1989
01:09:44,840 --> 01:09:45,800
TARGETED EXCEPTIONS AND THOSE

1990
01:09:45,800 --> 01:09:49,200
APPEAR IN THE RIGHT SIDE OF THE

1991
01:09:49,200 --> 01:09:50,280
TABLE.

1992
01:09:50,280 --> 01:09:52,080
SO THAT'S THE OUTLINE OF WHAT WE

1993
01:09:52,080 --> 01:09:54,280
DID THIS YEAR.

1994
01:09:54,280 --> 01:09:59,240
WE WILL NOT HAVE FISCAL YEAR IN

1995
01:09:59,240 --> 01:10:00,920
SEPTEMBER 30th AND AT THE END

1996
01:10:00,920 --> 01:10:02,800
OF THE CALENDAR YEAR OR SOMETIME

1997
01:10:02,800 --> 01:10:04,520
IN JANUARY, PERHAPS, WE WILL

1998
01:10:04,520 --> 01:10:06,920
HAVE THE SUMMATION, WE WILL KNOW

1999
01:10:06,920 --> 01:10:09,160
HOW MANY WE'VE FUNDED IN TOTAL,

2000
01:10:09,160 --> 01:10:11,560
AND ALL THE VARIOUS GRANT

2001
01:10:11,560 --> 01:10:12,400
SUBCATEGORIES AND WE ALWAYS

2002
01:10:12,400 --> 01:10:15,720
REPORT THAT OUT AS WELL. 

2003
01:10:15,720 --> 01:10:21,720
NNEXT SLIDE, PLEASE.

2004
01:10:21,720 --> 01:10:23,280
SO I'M JUST REMINDING YOU BACK

2005
01:10:23,280 --> 01:10:24,920
TO THE AGENDA, WE'RE MOVING ON

2006
01:10:24,920 --> 01:10:28,080
TO 2023 NOW AND WHAT THE OUTLOOK

2007
01:10:28,080 --> 01:10:29,400
LOOKS LIKE THERE.

2008
01:10:29,400 --> 01:10:31,000
SO NEXT SLIDE, AGAIN.

2009
01:10:31,000 --> 01:10:32,280
AND BEFORE I GET TOO DEEP INTO

2010
01:10:32,280 --> 01:10:35,000
IT, I JUST WANT TO COME BACK TO

2011
01:10:35,000 --> 01:10:39,560
1 THING, YOU SAW A MULTISLIDE

2012
01:10:39,560 --> 01:10:41,440
PRESENTATION HERE AND I MEAN THE

2013
01:10:41,440 --> 01:10:43,440
BIG QUESTION FOR 2023 IS WHAT IS

2014
01:10:43,440 --> 01:10:45,040
OUR APPROPRIATION, WHAT WILL OUR

2015
01:10:45,040 --> 01:10:47,080
APPROPRIATION ALLOW US TO AFFORD

2016
01:10:47,080 --> 01:10:50,040
IN TERMS OF NEW GRANTS AND THIS

2017
01:10:50,040 --> 01:10:54,600
SHOWS YEAR BY YEAR, IF WE MAKE

2018
01:10:54,600 --> 01:10:56,640
COMMITMENTS TO INCREASE THE PAY

2019
01:10:56,640 --> 01:10:59,160
LINE, GOING FROM THE TENTH

2020
01:10:59,160 --> 01:11:01,120
PERCENTILE IN THE FAR LEFT IN

2021
01:11:01,120 --> 01:11:04,920
RED AND MOVING TO THE 11th IN

2022
01:11:04,920 --> 01:11:07,720
21 AND 22, WE TAKE ON ADDITIONAL

2023
01:11:07,720 --> 01:11:09,640
BURDENS AND THAT'S AT THE BOTTOM

2024
01:11:09,640 --> 01:11:12,440
OF IT, IN THE DEEP RED, GREEN,

2025
01:11:12,440 --> 01:11:12,720
AND BLUE.

2026
01:11:12,720 --> 01:11:13,960
I THOUGHT ABOUT THIS A LITTLE

2027
01:11:13,960 --> 01:11:17,040
BIT AND I JUST CAME UP WITH THIS

2028
01:11:17,040 --> 01:11:18,760
ANALOGY, AND IT'S BEEN LIKE IF

2029
01:11:18,760 --> 01:11:29,240
YOU ARE CLIMBING A MOUNTAIN

2030
01:11:43,760 --> 01:11:45,040
AND--BUT IN BEARING THIS MIND

2031
01:11:45,040 --> 01:11:47,880
YOU, THAT PLAY OUT ACROSS FUTURE

2032
01:11:47,880 --> 01:11:49,600
FISCAL YEARS TYPICALLY 5 YEARS

2033
01:11:49,600 --> 01:11:51,240
FOR AN RO-1 AND YOU MOVE TO NEXT

2034
01:11:51,240 --> 01:11:53,240
BASE CAMP AND YOU HAVE THE PRIOR

2035
01:11:53,240 --> 01:11:57,480
YEAR'S BURDEN, YOU'RE PAYING AS

2036
01:11:57,480 --> 01:11:58,680
NONCOMPETING AND YOU'RE TAKING

2037
01:11:58,680 --> 01:12:00,120
ON ADDITIONAL BURDEN FOR THE

2038
01:12:00,120 --> 01:12:02,200
COMPETING YEAR AND MOVING TO YET

2039
01:12:02,200 --> 01:12:03,840
AGAIN THE NEXT BASE CAMP, YOU

2040
01:12:03,840 --> 01:12:05,720
HAVE THE PRIOR 2 YEARS, BURDEN

2041
01:12:05,720 --> 01:12:07,120
THAT YOU'RE CARRYING UP THAT

2042
01:12:07,120 --> 01:12:09,000
MOUNTAIN AND YOU WANT TO TAKE ON

2043
01:12:09,000 --> 01:12:12,560
ANOTHER BURDEN, SO IT DOES GROW,

2044
01:12:12,560 --> 01:12:15,000
IT'S A BURDEN WE WELCOME IF WE

2045
01:12:15,000 --> 01:12:16,920
CAN MANAGE IT AND THAT IS ALL

2046
01:12:16,920 --> 01:12:23,160
BEING MANAGED BY THE DOLLARS WE

2047
01:12:23,160 --> 01:12:23,440
RECEIVED.

2048
01:12:23,440 --> 01:12:25,640
SO LET ME DO THAT BY MOVING ON

2049
01:12:25,640 --> 01:12:27,000
TO THE NEXT SLIDE, PLEASE.

2050
01:12:27,000 --> 01:12:28,880
I JUST WANT TO SAY THERE ARE

2051
01:12:28,880 --> 01:12:29,800
OTHER FACTORS, WE TOUCHED ON

2052
01:12:29,800 --> 01:12:34,520
THIS, I WILL BE VERY BRIEF, YOU

2053
01:12:34,520 --> 01:12:36,280
KNOW ALL OUR DOLLARS DON'T COVER

2054
01:12:36,280 --> 01:12:40,160
THE GROWING VOLUME WITH MORE

2055
01:12:40,160 --> 01:12:42,440
AWARDS AND THEY LOSE VALUE

2056
01:12:42,440 --> 01:12:43,960
REERATED TO INFLATION AND THAT

2057
01:12:43,960 --> 01:12:46,360
WE HAVE SOME AWARDS THAT CAN

2058
01:12:46,360 --> 01:12:47,920
MOVE FROM 5-7 YEARS SO THAT LOAD

2059
01:12:47,920 --> 01:12:50,480
OF 5 YEARS IS 7 YEARS THAT

2060
01:12:50,480 --> 01:12:51,600
YOU'RE CARRYING, SO JUST WANT TO

2061
01:12:51,600 --> 01:12:54,880
TOUCH ON THAT AS WELL AND THEN

2062
01:12:54,880 --> 01:12:55,840
WE'LL MOVE ONCE AGAIN MOVING TO

2063
01:12:55,840 --> 01:13:00,280
THE NEXT SLIDE TO LOOK AT 2023

2064
01:13:00,280 --> 01:13:01,240
WITH THAT BACKGROUND AND YOU CAN

2065
01:13:01,240 --> 01:13:03,760
SEE THAT I HAVE ADDED IN THE FAR

2066
01:13:03,760 --> 01:13:06,280
RIGHT 2 ADDITIONAL COLUMNS, THEY

2067
01:13:06,280 --> 01:13:08,920
REFLECT THE HOUSE PROPOSED AND

2068
01:13:08,920 --> 01:13:10,880
THE SENATE PROPOSED, NEITHER OF

2069
01:13:10,880 --> 01:13:14,240
THESE BILLS HAVE BEEN CONSIDERED

2070
01:13:14,240 --> 01:13:16,800
IN THE FULL HOUSE AND THE

2071
01:13:16,800 --> 01:13:17,160
SENATE.

2072
01:13:17,160 --> 01:13:18,880
THEY'RE ALL RECOMMENDATIONS IN

2073
01:13:18,880 --> 01:13:23,440
SOME FORM OF ANOTHER BY THE

2074
01:13:23,440 --> 01:13:26,080
SUBCOMMITTEES OF JURISDICTION,

2075
01:13:26,080 --> 01:13:27,080
LABOR, HHS APPROPRIATIONS

2076
01:13:27,080 --> 01:13:27,440
SUBCOMMITTEE.

2077
01:13:27,440 --> 01:13:28,760
BUT YOU CAN SEE HERE, THE

2078
01:13:28,760 --> 01:13:31,920
INCREASED PROPOSED IN THE HOUSE

2079
01:13:31,920 --> 01:13:33,880
AND PROPOSED THROUGH THE SENATE,

2080
01:13:33,880 --> 01:13:38,400
AND WE ARE WATCHING THAT ALL

2081
01:13:38,400 --> 01:13:41,520
PLAY OUT IN CONGRESS NOW AND

2082
01:13:41,520 --> 01:13:43,120
I'LL DISAPPOINT YOU PROBABLY BY

2083
01:13:43,120 --> 01:13:47,480
SAYING THIS MAY PLAY OUT WELL

2084
01:13:47,480 --> 01:13:49,360
INTO THE FALL AND INTO THE

2085
01:13:49,360 --> 01:13:52,960
WINTER AND POSSIBLY EVEN INTO

2086
01:13:52,960 --> 01:13:55,400
THE SPRING OF LATE CONGRESS HAS

2087
01:13:55,400 --> 01:13:58,320
FACED ITS CHALLENGES GETTING

2088
01:13:58,320 --> 01:14:01,280
APPROPRIATIONS OUT EARLY IN THE

2089
01:14:01,280 --> 01:14:04,320
FISCAL YEAR AND IT IS WELL

2090
01:14:04,320 --> 01:14:06,880
COMMON THAT IT'S FEBRUARY,

2091
01:14:06,880 --> 01:14:10,760
MARCH, OR APRIL WHEN THINGS GET

2092
01:14:10,760 --> 01:14:11,040
RESOLVED.

2093
01:14:11,040 --> 01:14:13,240
IT TENDS TO BE MORE COMPLICATED

2094
01:14:13,240 --> 01:14:15,520
IN AN ELECTION YEAR WHICH WE ARE

2095
01:14:15,520 --> 01:14:20,760
IN AND SO, THAT'S, YOU KNOW THE

2096
01:14:20,760 --> 01:14:23,280
STRUGGLE AND UNCERTAINTY WE FACE

2097
01:14:23,280 --> 01:14:26,480
BUT THAT'S WHAT'S PENDING IN

2098
01:14:26,480 --> 01:14:28,320
CONGRESS AND IT ENTIRELY

2099
01:14:28,320 --> 01:14:31,200
REFLECTS WHAT DR. BARKER SAID,

2100
01:14:31,200 --> 01:14:32,840
IT IS A KEEN COMMITMENT TO THE

2101
01:14:32,840 --> 01:14:37,040
WORK WE DO AT NCI, AND TO THE

2102
01:14:37,040 --> 01:14:40,360
NEEDS OF CANCER DISCOVERY AND

2103
01:14:40,360 --> 01:14:41,080
CANCER PATIENTS, WE'VE SEEN

2104
01:14:41,080 --> 01:14:42,480
THAT, IF YOU JUST LOOK ACROSS

2105
01:14:42,480 --> 01:14:46,040
THE YEARS, YOU KNOW, OTHER THAN

2106
01:14:46,040 --> 01:14:48,800
MANY YEARS THAT THERE'S BEEN

2107
01:14:48,800 --> 01:14:50,280
BELT TIGHTENING, IN GOVERNMENT

2108
01:14:50,280 --> 01:14:53,880
IN GENERAL ACROSS THE 9 FISCAL

2109
01:14:53,880 --> 01:14:55,520
YEARS WE'RE LOOKING AT HERE, BUT

2110
01:14:55,520 --> 01:14:59,200
WE HAVE SEEN INCREASES,

2111
01:14:59,200 --> 01:15:03,000
MEANINGFUL INCREASES ACROSS THE

2112
01:15:03,000 --> 01:15:05,040
YEAR ENTIRELY REFLECTS WHAT

2113
01:15:05,040 --> 01:15:05,680
DR. BARKER MENTIONED PREVIOUSLY.

2114
01:15:05,680 --> 01:15:07,960
SO LET ME THEN MOVE ON TO THE

2115
01:15:07,960 --> 01:15:11,960
NEXT SLIDE WHICH WILL COMPARE,

2116
01:15:11,960 --> 01:15:13,440
THE FISCAL YEARS TO RECEIVE WHAT

2117
01:15:13,440 --> 01:15:22,440
THE GROWTH WAS FOR 2022 FROM

2118
01:15:22,440 --> 01:15:24,840
2024, IT WAS 5%, I'M GIVING YOU

2119
01:15:24,840 --> 01:15:30,160
THE NIH TOTAL AS WELL AND AT

2120
01:15:30,160 --> 01:15:32,040
7.6% INCREASE GROWING INTO 2022,

2121
01:15:32,040 --> 01:15:36,400
AT THE BOTTOM FOR NCI, THEY

2122
01:15:36,400 --> 01:15:37,800
CHALLENGED US, CONGRESS

2123
01:15:37,800 --> 01:15:39,600
CHALLENGED US TO INCREASE,

2124
01:15:39,600 --> 01:15:41,520
COMPETING AND CONTINUING GRANTS,

2125
01:15:41,520 --> 01:15:43,200
NONCOMPETING GRANTS AS WELL, YOU

2126
01:15:43,200 --> 01:15:46,200
KNOW IT'S CONTINUING GRANTS BY

2127
01:15:46,200 --> 01:15:47,560
150 MILLION, AND THAT'S A TARGET

2128
01:15:47,560 --> 01:15:49,920
WE'RE DETERMINED TO MEET IN 2022

2129
01:15:49,920 --> 01:15:52,480
AND WATCH IT CAREFULLY AND

2130
01:15:52,480 --> 01:15:54,520
EVERYTHING SEEMS TO BE ON PATH

2131
01:15:54,520 --> 01:16:02,720
TO DO JUST THAT FOR NCI FOR

2132
01:16:02,720 --> 01:16:03,680
FISCAL YEAR 2022.

2133
01:16:03,680 --> 01:16:05,440
FOR 2023, WE SEE 2 APPROACHES

2134
01:16:05,440 --> 01:16:07,000
HERE FOR THE HOUSE AND THE

2135
01:16:07,000 --> 01:16:09,000
SENATE AND FOR NCI AND NIH, THE

2136
01:16:09,000 --> 01:16:11,760
HOUSE A BIT MORE GENEROUS, 6.7%,

2137
01:16:11,760 --> 01:16:15,600
THAT CERTAINLY IS GENEROUS BUT

2138
01:16:15,600 --> 01:16:18,760
THE SENATE IS SIMILARLY

2139
01:16:18,760 --> 01:16:20,800
GENEROUS, 4.2% AND WE'RE

2140
01:16:20,800 --> 01:16:22,480
WATCHING THOSE 2, IF THEY WERE

2141
01:16:22,480 --> 01:16:24,360
TO SIMPLY SPLIT THE DIFFERENCE

2142
01:16:24,360 --> 01:16:27,280
IT WOULD BE ABOUT A

2143
01:16:27,280 --> 01:16:27,840
375 MILLION-DOLLAR INCREASE.

2144
01:16:27,840 --> 01:16:35,000
WE HAVE TO SEE IF THAT'S WHAT

2145
01:16:35,000 --> 01:16:41,320
THEY DO AND IF THEY WERE

2146
01:16:41,320 --> 01:16:42,560
FAVORABLE OR UNFAVORABLY FOR

2147
01:16:42,560 --> 01:16:47,360
BUDGETS FOR THE NIH OR NCI IN

2148
01:16:47,360 --> 01:16:47,760
PARTICULAR.

2149
01:16:47,760 --> 01:16:51,360
AND SO, THERE YOU SEE HOUSE AND

2150
01:16:51,360 --> 01:16:52,840
SENATE NUMBERS FOR 2023 AND

2151
01:16:52,840 --> 01:16:57,080
WE'RE WATCHING ALL OF THAT AND

2152
01:16:57,080 --> 01:17:02,520
TRYING TO GET THE BEST OUTCOME

2153
01:17:02,520 --> 01:17:05,880
FOR NCI, LET ME MOVE TO THE NEXT

2154
01:17:05,880 --> 01:17:07,400
SLIDE, PLEASE.

2155
01:17:07,400 --> 01:17:09,960
ARP A H UP, I'M HERE AND I'M

2156
01:17:09,960 --> 01:17:10,640
DISPLAY THAGOREAN INFORMATION AS

2157
01:17:10,640 --> 01:17:13,560
WELL AND I'M DOING IT IN 2 WAYS,

2158
01:17:13,560 --> 01:17:17,200
WHAT THE DOLLAR AMOUNT WAS AND

2159
01:17:17,200 --> 01:17:22,480
WHO MANAGES THE PROGRAM AND SO

2160
01:17:22,480 --> 01:17:24,640
IN 2022, IN THE END IT WAS

2161
01:17:24,640 --> 01:17:26,600
SOMETHINGED BY NIH BUT

2162
01:17:26,600 --> 01:17:27,200
ORIGINALLY THE AUTHORITY WAS

2163
01:17:27,200 --> 01:17:29,160
GIVEN TO THE SECRETARY WITH

2164
01:17:29,160 --> 01:17:30,800
AUTHORITY TO DELEGATE TO NIHR

2165
01:17:30,800 --> 01:17:35,400
WHICH THE SECOND DID EXERCISE

2166
01:17:35,400 --> 01:17:37,120
AND THE OMOUNT WAS A MILLION

2167
01:17:37,120 --> 01:17:40,440
DOLLAR FOR ARP,A H, 2023, WE SEE

2168
01:17:40,440 --> 01:17:45,560
HOUSE AND SENATE ARE PROPOSING

2169
01:17:45,560 --> 01:17:46,200
DIFFERENT TOTALS, CONSIDERABLY

2170
01:17:46,200 --> 01:17:48,200
LESS THAN WHAT THE

2171
01:17:48,200 --> 01:17:49,360
ADMINISTRATION WANTED AT 5

2172
01:17:49,360 --> 01:17:53,480
BILLION AND WE ONCE AGAIN SEE, A

2173
01:17:53,480 --> 01:17:55,840
BACK AND FORTH CONSIDERATION

2174
01:17:55,840 --> 01:17:58,520
ABOUT WHERE ITS HOME SHOULD BE,

2175
01:17:58,520 --> 01:18:04,920
THE HOUSE, DELEGATES IT TO HHS

2176
01:18:04,920 --> 01:18:06,840
AND THE AND THE SENATE HAS IT

2177
01:18:06,840 --> 01:18:08,920
STAYING AT NIH, SO, IT'S ANOTHER

2178
01:18:08,920 --> 01:18:15,200
WATCH AND WAIT AND SEE.

2179
01:18:15,200 --> 01:18:18,400
AS TO WHERE THIS WILL GO, WHY WE

2180
01:18:18,400 --> 01:18:20,480
TALK ABOUT ARP A H BECAUSE WHEN

2181
01:18:20,480 --> 01:18:22,000
IT WAS FRAMED BY THE PRESIDENT

2182
01:18:22,000 --> 01:18:23,880
AND CONTINUES TO BE DISCUSSED

2183
01:18:23,880 --> 01:18:30,400
BUSINESS CANCER, THE NEEDS AND

2184
01:18:30,400 --> 01:18:34,320
THEY'RE CHARGED WITH ADVANCING,

2185
01:18:34,320 --> 01:18:38,240
AND THAT'S WHY IT WILL RELATE TO

2186
01:18:38,240 --> 01:18:41,040
THE WORK OF THE NATIONAL CANCER

2187
01:18:41,040 --> 01:18:42,640
INSTITUTE, WE'RE HAVING

2188
01:18:42,640 --> 01:18:43,960
DISCUSSIONS, WORKING TO FRAME UP

2189
01:18:43,960 --> 01:18:46,160
IDEAS THAT WILL BE SUITABLE FOR

2190
01:18:46,160 --> 01:18:50,560
AN RARP A H TYPE PROJECT RELATED

2191
01:18:50,560 --> 01:18:54,120
TO CANCER; AND THAT'S ALL FOR

2192
01:18:54,120 --> 01:18:56,640
THIS SLIDE, I LET ME MOVE ON

2193
01:18:56,640 --> 01:18:58,920
ONCE AGAIN AND I WILL MOVE TO

2194
01:18:58,920 --> 01:19:00,120
2024 NEXT, ASK BUT LET ME JUST

2195
01:19:00,120 --> 01:19:02,640
STOP AND SEE IF THERE'S ANYTHING

2196
01:19:02,640 --> 01:19:03,480
AT THIS JUNKT THAT YOU ARE

2197
01:19:03,480 --> 01:19:04,680
ANYONE WANTS TO JUMP IN WITH AND

2198
01:19:04,680 --> 01:19:08,480
I WILL MOVE ON TO 2024.

2199
01:19:08,480 --> 01:19:11,000
>> SO PATRICK CAN YOU SAY
A BIT

2200
01:19:11,000 --> 01:19:13,040
MORE AND MK MAY TALK ABOUT THIS

2201
01:19:13,040 --> 01:19:13,880
IN HER LEGISLATIVE UPDATE BUT

2202
01:19:13,880 --> 01:19:18,320
CAN YOU SAY A BIT MORE ABOUT THE

2203
01:19:18,320 --> 01:19:21,160
THINKING AND MAYBE THIS IS A

2204
01:19:21,160 --> 01:19:23,680
2024 DISCUSSION, BUT,

2205
01:19:23,680 --> 01:19:24,960
CONSIDERING THE MOON SHOT FUNDS

2206
01:19:24,960 --> 01:19:28,400
THAT WE WILL EXPEND IN 2023, AND

2207
01:19:28,400 --> 01:19:32,040
WE'RE LOOKING AT A SIGNIFICANT

2208
01:19:32,040 --> 01:19:34,280
DEFICIT THEN UNLESS SOMETHING

2209
01:19:34,280 --> 01:19:36,360
HAPPENS, IS THERE A DISCUSSION

2210
01:19:36,360 --> 01:19:39,120
OF THAT AS PART OF EITHER THE

2211
01:19:39,120 --> 01:19:41,480
SENATE OR THE HOUSE'S

2212
01:19:41,480 --> 01:19:42,160
DELIBERATIONS AT THIS POINT OR

2213
01:19:42,160 --> 01:19:45,320
HAS IT COME UP?

2214
01:19:45,320 --> 01:19:55,000
>> WELL, YOU MAKE 2 GOOD
POINTS,

2215
01:19:55,000 --> 01:19:56,120
TECHNICALLY NO, BECAUSE THEY'RE

2216
01:19:56,120 --> 01:19:57,040
DISCUSSING THE FINAL YEAR SO

2217
01:19:57,040 --> 01:19:58,800
THEY WOULD NEED TO ACTOT 2024

2218
01:19:58,800 --> 01:20:00,360
BUDGET AND OF COURSE THE

2219
01:20:00,360 --> 01:20:03,680
ADMINISTRATION WILL FRAME AND

2220
01:20:03,680 --> 01:20:07,120
PROPOSE A 2022 BUDGET, SO

2221
01:20:07,120 --> 01:20:10,320
WE--BOTH BILLS HAVE THE FULL

2222
01:20:10,320 --> 01:20:12,520
AMOUNT, 216 MILLION WHICH IS THE

2223
01:20:12,520 --> 01:20:13,960
FINAL INSTALLMENT OF 70 YEARS OF

2224
01:20:13,960 --> 01:20:16,880
MOON SHOT, THE FIRST MOON SHOT,

2225
01:20:16,880 --> 01:20:22,080
AND WE FULLY EXPECT THAT BECAUSE

2226
01:20:22,080 --> 01:20:23,720
THEY EVERY YEAR WITHOUT FAIL

2227
01:20:23,720 --> 01:20:25,760
ACROSS THE PRIOR 6 YEARS WE'VE

2228
01:20:25,760 --> 01:20:27,120
GOTTEN THE FULL DESIGNATED

2229
01:20:27,120 --> 01:20:28,920
AMOUNT AND WE DON'T SEE ANY

2230
01:20:28,920 --> 01:20:33,320
REASON WHY THEY WON'T DO THE

2231
01:20:33,320 --> 01:20:34,640
SAME BUT IT'S A STEP AHEAD TO

2232
01:20:34,640 --> 01:20:37,400
CONSIDER WHAT THEY WILL DO FOR

2233
01:20:37,400 --> 01:20:38,720
2024 AND MAYBE WE CAN DISCUSS

2234
01:20:38,720 --> 01:20:42,600
THAT MORE AT THE NEXT SLIDES BUT

2235
01:20:42,600 --> 01:20:49,920
WE KNOW THAT THERE IS HIGH

2236
01:20:49,920 --> 01:20:51,200
CONSCIOUSNESS ABOUT THAT, WE'VE

2237
01:20:51,200 --> 01:20:52,840
CALLED THAT A PARTIAL CLIP

2238
01:20:52,840 --> 01:20:55,360
BECAUSE THERE ACTUALLY WAS A

2239
01:20:55,360 --> 01:21:01,160
REDUCTION IN MIDPOINT GOING FROM

2240
01:21:01,160 --> 01:21:05,480
400 MILLION IN FY2019 DOWN THE

2241
01:21:05,480 --> 01:21:09,600
NCI MOON SHOT DOLLARS DOWN TO

2242
01:21:09,600 --> 01:21:15,400
195, THERE ABOUTS IN FY2020, SO

2243
01:21:15,400 --> 01:21:16,840
SO WE DID FAKE THAT AND CONGRESS

2244
01:21:16,840 --> 01:21:20,320
DID STEP IN AND RESOURCE THE NCI

2245
01:21:20,320 --> 01:21:23,440
BUDGET SUCH THAT WE REALLY HAVE

2246
01:21:23,440 --> 01:21:26,320
THAT LOSS, THE MONITOR SHOT IS A

2247
01:21:26,320 --> 01:21:28,360
DESIGNATED AMOUNT SO THEY DIDN'T

2248
01:21:28,360 --> 01:21:29,440
INCREASE IT IN MOON SHOT BUT

2249
01:21:29,440 --> 01:21:30,920
THEY GAVE US THE REDUCTION

2250
01:21:30,920 --> 01:21:32,320
AMOUNT IF YOU WILL IN OUR

2251
01:21:32,320 --> 01:21:35,000
REGULAR BUDGET SO WE WERE MADE

2252
01:21:35,000 --> 01:21:42,360
WHOLE, IT'S A SUMMATION OF WHAT

2253
01:21:42,360 --> 01:21:47,000
I JUST SAID, SO WHY KNOW THERE'S

2254
01:21:47,000 --> 01:21:48,480
A LOT OF CONSCIOUS ABOUT IT AND

2255
01:21:48,480 --> 01:21:50,800
WE KNOW THEY WON'T MISTAKE IT

2256
01:21:50,800 --> 01:21:52,120
AND FORGET ABOUT BUT WE HAVE TO

2257
01:21:52,120 --> 01:21:55,000
WATCH THAT ROLL OUT IN THE

2258
01:21:55,000 --> 01:21:56,880
COMING ADMINISTRATION'S BUDGET

2259
01:21:56,880 --> 01:21:58,360
IN 2024 FISCAL YEAR.

2260
01:21:58,360 --> 01:21:59,520
>> INDEED, ANY RECOLLECT

2261
01:21:59,520 --> 01:22:03,600
QUESTIONS FOR PATRICK UP TO THIS

2262
01:22:03,600 --> 01:22:03,920
POINT?

2263
01:22:03,920 --> 01:22:06,160
>> DONE YOUR USUAL GOOD
JOB

2264
01:22:06,160 --> 01:22:06,720
PATTIC.

2265
01:22:06,720 --> 01:22:07,560
LET'S GO ON.

2266
01:22:07,560 --> 01:22:09,400
LET'S GO ON TO THE NEXT SLIDE,

2267
01:22:09,400 --> 01:22:11,360
BRIEFLY, JUST FRAMING UP, I'M

2268
01:22:11,360 --> 01:22:12,640
MOVING ON TO 24 WHICH I ALREADY

2269
01:22:12,640 --> 01:22:20,040
TOLD YOU SO WE CAN GO 1 MORE

2270
01:22:20,040 --> 01:22:20,400
SLIDE, PLEASE.

2271
01:22:20,400 --> 01:22:23,080
AND AND HERE WE ARE, THAT'S THE

2272
01:22:23,080 --> 01:22:25,280
SECOND OF FEBRUARY, IN 2022 IN

2273
01:22:25,280 --> 01:22:28,600
THE EAST ROOM OF THE WHITE HOUSE

2274
01:22:28,600 --> 01:22:34,240
AND THE PRESIDENT ANNOUNCING HIS

2275
01:22:34,240 --> 01:22:36,120
CANCER MOONSHOT, AND YOU KNOW I

2276
01:22:36,120 --> 01:22:42,440
WILL DIGRESS FOR A MOMENT IF YOU

2277
01:22:42,440 --> 01:22:45,040
WILL AND JUST TALK ABOUT THIS

2278
01:22:45,040 --> 01:22:54,880
WEEK, WE MAY BE SEEING THE FIRST

2279
01:22:54,880 --> 01:22:56,360
RETURN TO, YOU KNOW SPACE

2280
01:22:56,360 --> 01:22:58,720
DISCOVERY HEADING TO THE MOON

2281
01:22:58,720 --> 01:23:00,920
WITH ARTEMIS, ANDY WOO KNOW THAT

2282
01:23:00,920 --> 01:23:07,640
APOLLO WAS MODEST RELATIVE TO

2283
01:23:07,640 --> 01:23:11,160
ARTEMIS, AND WE SEE HERE

2284
01:23:11,160 --> 01:23:12,320
SIMILARLY THE SUPERCHARGE MOON

2285
01:23:12,320 --> 01:23:13,680
SHOT THAT THE PRESIDENT

2286
01:23:13,680 --> 01:23:19,640
ARTICULATED IS FAR BOLDER AS

2287
01:23:19,640 --> 01:23:21,040
ARTEMIS'S, AND AN ANALOGY I'M

2288
01:23:21,040 --> 01:23:23,200
USING AND I THINK IT FITS IN

2289
01:23:23,200 --> 01:23:25,600
SOME WAYS AND IT'S, YOU KNOW THE

2290
01:23:25,600 --> 01:23:31,240
GOALS HERE ON THE SLIDE THAT THE

2291
01:23:31,240 --> 01:23:32,520
PRESIDENT ARTICULATED REDUCING

2292
01:23:32,520 --> 01:23:34,480
AGE JUSTED DEATH RATE FROM

2293
01:23:34,480 --> 01:23:38,600
CANCER BY AT LEAST 50% AND THEN

2294
01:23:38,600 --> 01:23:39,960
TRANSFORMING THE MEANING OF

2295
01:23:39,960 --> 01:23:41,960
CANCER WHICH INCLUDES IMPROVING

2296
01:23:41,960 --> 01:23:45,120
THE EXPERIENCE OF PEOPLE LIVING

2297
01:23:45,120 --> 01:23:46,160
WITH CANCER, SURVIVING CANCER

2298
01:23:46,160 --> 01:23:51,040
AND THEN ADDRESSING CANCER

2299
01:23:51,040 --> 01:23:52,440
HEALTH DISPARITIES BY MEETING

2300
01:23:52,440 --> 01:23:54,320
THE NEEDS OF UNDERSERVED, THESE

2301
01:23:54,320 --> 01:23:56,280
ARE ALL BIG CHALLENGES THAT THE

2302
01:23:56,280 --> 01:24:04,040
SUPERCHARGE MOON SHOT IS TAKING

2303
01:24:04,040 --> 01:24:06,200
ON AND WE REALLY WATCH AND WAIT

2304
01:24:06,200 --> 01:24:10,560
TO SEE HOW IN THE 2024 BUDGET

2305
01:24:10,560 --> 01:24:12,680
WILL BE RESOURCED, NOT NCI ALONE

2306
01:24:12,680 --> 01:24:17,480
BUT OF COURSE, WITH A FLAG SHIP

2307
01:24:17,480 --> 01:24:18,360
ON BIOMALRESEARCH AND CANCER

2308
01:24:18,360 --> 01:24:22,440
SCIENCE, SO WE WILL WATCH AND

2309
01:24:22,440 --> 01:24:23,760
SEE HOW THAT THAT COMES FORWARD

2310
01:24:23,760 --> 01:24:27,480
IN THE BUDGET THAT'S HOW BEING

2311
01:24:27,480 --> 01:24:28,640
FRAMED, NEXT SLIDE, PLEASE,

2312
01:24:28,640 --> 01:24:32,040
HOWEVER I WANT TO SAY THAT YOU

2313
01:24:32,040 --> 01:24:34,800
KNOW WE'RE NOT BY NO MEANS IDLE,

2314
01:24:34,800 --> 01:24:42,280
WE ARE DEEPLY ENGAGED AND YOU

2315
01:24:42,280 --> 01:24:44,400
KNOW WE HAVE INITIATIVES WE'RE

2316
01:24:44,400 --> 01:24:52,120
START NOTHING 2023, 2 OF THESE

2317
01:24:52,120 --> 01:24:54,920
WERE RFAs THAT CAME BEFORE THE

2318
01:24:54,920 --> 01:24:55,960
JOINT MEETING IN JUNE AND THE

2319
01:24:55,960 --> 01:24:59,880
FIRST WAS MOON SHOT SCHOLARS,

2320
01:24:59,880 --> 01:25:02,840
THE SECOND WAS INITIATIVE, RFA

2321
01:25:02,840 --> 01:25:03,800
INITIATIVE IN MULTICANCKER

2322
01:25:03,800 --> 01:25:09,240
DETECTION TESTS AND BOTH OF

2323
01:25:09,240 --> 01:25:10,760
THESE WERE CLEARLY BROUGHT FORTH

2324
01:25:10,760 --> 01:25:12,160
AND FIT PERFECTLY WELL WITHIN

2325
01:25:12,160 --> 01:25:20,680
THE GOALS AND PRIORITIES OF THE

2326
01:25:20,680 --> 01:25:22,880
ADMINISTRATION FOR THE SUPER

2327
01:25:22,880 --> 01:25:24,920
CHARGE MOON SHOT, MANAGING AT

2328
01:25:24,920 --> 01:25:27,480
THE MEETING THE PRESIDENT

2329
01:25:27,480 --> 01:25:29,360
ANNOUNCED THE FORMATION OF A

2330
01:25:29,360 --> 01:25:31,560
CANCER CABINET WHICH NCI HAS A

2331
01:25:31,560 --> 01:25:34,400
SEAT ON AND SOON THEREAFTER, A

2332
01:25:34,400 --> 01:25:35,800
MONTH OR AFTER AT THE FIRST

2333
01:25:35,800 --> 01:25:38,000
MEETING OF THE CANCER CABINET,

2334
01:25:38,000 --> 01:25:39,600
THE CANCER CABINET AMONG THEIR

2335
01:25:39,600 --> 01:25:42,120
ANNOUNCEMENTS, NOT JUST THE ONLY

2336
01:25:42,120 --> 01:25:43,440
1 WAS THEIR CANCER MOONSHOT

2337
01:25:43,440 --> 01:25:45,160
SCHOLARS PROGRAM SO WE HAD THAT

2338
01:25:45,160 --> 01:25:49,480
BEING FRAMED UP AND WE BROUGHT

2339
01:25:49,480 --> 01:25:52,240
THAT TO THE JOINT BOARD MEETING

2340
01:25:52,240 --> 01:25:54,960
AND THE BSA ASCENTED AND SO

2341
01:25:54,960 --> 01:25:59,720
THAT'S 1 AND YET ANOTHER IS THE

2342
01:25:59,720 --> 01:26:01,200
EARLY DETECTION.

2343
01:26:01,200 --> 01:26:04,040
EVALUATION, EARLY DETECTION

2344
01:26:04,040 --> 01:26:06,200
TESTS, SO, I JUST WANT TO JUST

2345
01:26:06,200 --> 01:26:12,920
PAINT THE PICTURE THAT WE'RE--I

2346
01:26:12,920 --> 01:26:13,800
GUESS, PERHAPS, ARTEMIS'S IS NOT

2347
01:26:13,800 --> 01:26:15,440
GOING TO THE MOON BUT IT'S

2348
01:26:15,440 --> 01:26:16,680
MAKING READY, AND HERE WE ARE

2349
01:26:16,680 --> 01:26:18,120
MAKING READY AND WE'RE

2350
01:26:18,120 --> 01:26:21,080
OPERATIONALIZING THESE AND OTHER

2351
01:26:21,080 --> 01:26:23,360
THINGS SO THAT WE'RE WELL

2352
01:26:23,360 --> 01:26:25,880
POSITIONED NOT JUST IN THESE 2

2353
01:26:25,880 --> 01:26:27,520
AREAS, THESE ARE 2 GOOD

2354
01:26:27,520 --> 01:26:30,720
EXAMPLES, BECAUSE OF OF ACTIVITY

2355
01:26:30,720 --> 01:26:34,320
THAT YOU'VE SEEN IN PRIOR MONTHS

2356
01:26:34,320 --> 01:26:35,600
BUT THESE ARE THE KINDS OF

2357
01:26:35,600 --> 01:26:37,800
THINGS THAT WE'RE ENGAGED IN SO

2358
01:26:37,800 --> 01:26:40,760
THAT WE CAN MAKE THE SUPERCHARGE

2359
01:26:40,760 --> 01:26:42,320
MOON SHOT, THE SUCCESS THAT WE

2360
01:26:42,320 --> 01:26:45,400
HOPE IT TO BE AND TO ACHIEVE

2361
01:26:45,400 --> 01:26:54,040
THOSE BOLD GOALS THAT THE

2362
01:26:54,040 --> 01:26:54,880
ADMINISTRATION ARTICULATED.

2363
01:26:54,880 --> 01:26:56,760
AND THAT'S WHAT I CAN SAY MORE

2364
01:26:56,760 --> 01:26:59,080
OR LESS ON 2024, IT'S NOT ALL

2365
01:26:59,080 --> 01:27:00,640
ABOUT MOON SHOT, WE HAVE THE

2366
01:27:00,640 --> 01:27:01,440
BASE BUDGET WE'RE DEFENDING AND

2367
01:27:01,440 --> 01:27:03,120
1 OF THE THINGS WE'VE BEEN

2368
01:27:03,120 --> 01:27:05,200
SAYING IS THAT, YOU KNOW THE

2369
01:27:05,200 --> 01:27:06,600
ADMINISTRATION AND WE HAD LIKE

2370
01:27:06,600 --> 01:27:08,560
MANY WANT TO MOVE BOLDLY

2371
01:27:08,560 --> 01:27:10,040
FORWARD, BUT WE CAN'T LOSE

2372
01:27:10,040 --> 01:27:12,680
GROUND ON OUR BASE BUDGET

2373
01:27:12,680 --> 01:27:15,560
ANALOGY IS SOMEWHAT, YOU

2374
01:27:15,560 --> 01:27:17,920
KNOW--WILL BE 2 STEPS FORWARD

2375
01:27:17,920 --> 01:27:19,920
WITH SUPER CHARGED MOON SHOT AND

2376
01:27:19,920 --> 01:27:23,680
1 STEP BACKWARDS IF WE CAN'T

2377
01:27:23,680 --> 01:27:24,520
MAINTAIN THE BASIC RESEARCH AND

2378
01:27:24,520 --> 01:27:27,240
OTHER AREAS OF RESEARCH IN OUR

2379
01:27:27,240 --> 01:27:30,680
BASE BUDGET THAT WE NEED TO

2380
01:27:30,680 --> 01:27:32,840
SUSTAIN BECAUSE THOSE WILL MAKE

2381
01:27:32,840 --> 01:27:35,360
THE CONTRIBUTIONS JUST AS THE

2382
01:27:35,360 --> 01:27:37,280
SUPER CHARGED MOON SHOT WILL

2383
01:27:37,280 --> 01:27:42,120
WILL MAKE THE CONTRIBUTIONS TO

2384
01:27:42,120 --> 01:27:43,400
ACHIEVE THOSE GOALS.

2385
01:27:43,400 --> 01:27:46,520
IT'S NOT ALL DRIVEN EXCLUSIVELY

2386
01:27:46,520 --> 01:27:48,400
BY SUPER CHARGED MOON SHOT,

2387
01:27:48,400 --> 01:27:50,800
THERE ARE ONGOING INVESTMENTS

2388
01:27:50,800 --> 01:27:52,880
THAT CONTINUE TO DELIVER RESULTS

2389
01:27:52,880 --> 01:27:55,720
THAT YOU AND SO MANY ARE

2390
01:27:55,720 --> 01:27:57,080
FAMILIAR WITH.

2391
01:27:57,080 --> 01:27:59,480
THAT'S MY LAST SLIDE.

2392
01:27:59,480 --> 01:28:06,120
YOU COULD MOVE TO QUESTIONS FROM

2393
01:28:06,120 --> 01:28:06,520
THE SUBCOMMITTEE.

2394
01:28:06,520 --> 01:28:08,040
>> WELL IF YOU HAVE
QUESTIONS

2395
01:28:08,040 --> 01:28:09,440
JUST PUT YOUR HAND UP.

2396
01:28:09,440 --> 01:28:10,960
OTHERWISE I WILL ASK QUESTIONS.

2397
01:28:10,960 --> 01:28:13,840
JOHN ARE YOU WANTING TO ASK A

2398
01:28:13,840 --> 01:28:17,960
QUESTION? 

2399
01:28:17,960 --> 01:28:18,560
THERE YOU GO.

2400
01:28:18,560 --> 01:28:21,840
>> NO QUESTION FROM JOHN.

2401
01:28:21,840 --> 01:28:25,200
>> YEAH, THANKS, ANN. 

2402
01:28:25,200 --> 01:28:26,520
BUDGET AND PLANNING I CAN'T HELP

2403
01:28:26,520 --> 01:28:29,160
BUT WONDER A BIT MORE ABOUT THE

2404
01:28:29,160 --> 01:28:31,120
MOON SHOT AND THE PLANNING FOR

2405
01:28:31,120 --> 01:28:33,600
IT AND I KNOW WE ORIGINALLY

2406
01:28:33,600 --> 01:28:35,080
THERE WAS A BLUE RIBBON PANEL

2407
01:28:35,080 --> 01:28:39,480
AND YOU KNOW A LOT OF THE

2408
01:28:39,480 --> 01:28:40,280
RECOMMENDATIONS WERE DEVELOPED

2409
01:28:40,280 --> 01:28:41,120
AROUND THAT COLLECTION OF

2410
01:28:41,120 --> 01:28:42,520
INDIVIDUALS AND JUST TRYING TO

2411
01:28:42,520 --> 01:28:44,320
FIGURE OUT HAS THERE BEEN ANY

2412
01:28:44,320 --> 01:28:45,640
THOUGHT OR DISCUSSION INTO WHAT

2413
01:28:45,640 --> 01:28:46,800
THE PROCESS WILL BE?

2414
01:28:46,800 --> 01:28:49,200
WILL IT BE THE SAME PROCESS?

2415
01:28:49,200 --> 01:28:51,800
OR WILL IT BE I'M ASSUMING WITH

2416
01:28:51,800 --> 01:28:52,960
THE CANCER CABINET, I WOULD

2417
01:28:52,960 --> 01:28:56,440
ASSUME IT'S NOT GOING TO BE THE

2418
01:28:56,440 --> 01:28:56,640
SAME.

2419
01:28:56,640 --> 01:28:58,080
IT WOULD BE AT LEAST DIFFERENT

2420
01:28:58,080 --> 01:28:59,360
BUT HAVE YOU HEARD OF ANYTHING,

2421
01:28:59,360 --> 01:29:01,560
HAVE YOU HEARD OF DOUG OR DANA

2422
01:29:01,560 --> 01:29:03,120
OR ANYONE HAS ANY IDEA HOW THE

2423
01:29:03,120 --> 01:29:04,440
PRIORITIES WILL BE SET, HOW

2424
01:29:04,440 --> 01:29:06,840
MECHANISMS WILL BE DEVELOPED?

2425
01:29:06,840 --> 01:29:11,480
IT MIGHT BE TOO PREMATURE, I'M

2426
01:29:11,480 --> 01:29:12,560
JUST WONDERING THOUGH?

2427
01:29:12,560 --> 01:29:17,840
>> JOHN, WHY DON'T I STEP
IN.

2428
01:29:17,840 --> 01:29:18,400
GREAT QUESTION.

2429
01:29:18,400 --> 01:29:21,720
CERTAINLY THERE IS GOING TO BE

2430
01:29:21,720 --> 01:29:25,000
MORE INVOLVEMENT IF YOU WILL OF

2431
01:29:25,000 --> 01:29:26,800
GOVERNMENT BEYOND WHAT IT WAS

2432
01:29:26,800 --> 01:29:30,800
FOR THE MOON SHOT, PROBABLY WITH

2433
01:29:30,800 --> 01:29:38,000
FUNDING AS WELL AS IN TERMS OF

2434
01:29:38,000 --> 01:29:38,840
OTHER OPPORTUNITIES BUT AS I

2435
01:29:38,840 --> 01:29:41,720
WILL POINT OUT IN MY REMARKS

2436
01:29:41,720 --> 01:29:45,120
DURING THE REGULAR PART OF THE

2437
01:29:45,120 --> 01:29:48,800
MEETING, THE NCI AND THE FDA ARE

2438
01:29:48,800 --> 01:29:52,440
REALLY THE ONLY GROUPS OR

2439
01:29:52,440 --> 01:29:56,280
AGENCIES THAT ARE INVOLVED IN

2440
01:29:56,280 --> 01:29:58,280
CHANGING STANDARD OF CARE AND I

2441
01:29:58,280 --> 01:30:01,000
THINK THAT THIS ACTUALLY IS A

2442
01:30:01,000 --> 01:30:03,400
CRITICALLY IMPORTANT WAY OF US

2443
01:30:03,400 --> 01:30:06,080
NOT JUST TO POSITION OURSELVES,

2444
01:30:06,080 --> 01:30:12,680
BUT TO TRY TO HELP PATIENTS WITH

2445
01:30:12,680 --> 01:30:15,680
CANCER BECAUSE, YOU KNOW THE

2446
01:30:15,680 --> 01:30:16,480
PRESIDENT ARTICULATES TRYING TO

2447
01:30:16,480 --> 01:30:22,400
END CANCER AS WE KNOW IT AND AS

2448
01:30:22,400 --> 01:30:24,360
PATRICK POINTS OUT DECREASING

2449
01:30:24,360 --> 01:30:27,320
MORTALITY RATES BY 50% OR MORE,

2450
01:30:27,320 --> 01:30:29,680
BUT IF WE DON'T--IF WE CAN'T

2451
01:30:29,680 --> 01:30:31,120
HELP PEOPLE WITH PANCREATIC

2452
01:30:31,120 --> 01:30:33,840
CANCER AND OTHER CANCER TYPES,

2453
01:30:33,840 --> 01:30:36,800
WHICH WE DON'T HAVE A GOOD

2454
01:30:36,800 --> 01:30:39,000
OUTLOOK, WE REALLY NOT GOING TO

2455
01:30:39,000 --> 01:30:43,040
BE ENDING CANCER AS WE KNOW IT.

2456
01:30:43,040 --> 01:30:44,240
>> YOU KNOW DOUG, YOU ARE
SO

2457
01:30:44,240 --> 01:30:44,680
RIGHT ON.

2458
01:30:44,680 --> 01:30:48,240
I MEAN, I THINK THAT'S EXACTLY

2459
01:30:48,240 --> 01:30:49,640
THE RIGHT ANSWER BECAUSE IF YOU

2460
01:30:49,640 --> 01:30:51,240
LOOK AT WHAT THIS PRESIDENT SAID

2461
01:30:51,240 --> 01:30:52,680
TIME AND TIME AGAIN, IT'S THAT.

2462
01:30:52,680 --> 01:30:54,760
HOW DO WE GET THE BEST STANDARD

2463
01:30:54,760 --> 01:30:58,000
OF CARE FOR EVERY PATIENT?

2464
01:30:58,000 --> 01:31:00,440
>> DINA MAY WANT TO
COMMENT IN

2465
01:31:00,440 --> 01:31:00,720
ADDITION.

2466
01:31:00,720 --> 01:31:03,560
>> YEAH, BUT BEFORE THAT,
I JUST

2467
01:31:03,560 --> 01:31:05,080
WANT TO SAY I THINK YOU KNOW

2468
01:31:05,080 --> 01:31:07,080
PERHAPS IT'S TIME TO REENVISION

2469
01:31:07,080 --> 01:31:09,240
THE WHOLE CONCEPT OF STANDARD OF

2470
01:31:09,240 --> 01:31:09,600
CARE.

2471
01:31:09,600 --> 01:31:11,840
I THINK STANDARD OF CARE

2472
01:31:11,840 --> 01:31:12,920
CURRENTLY SITS WITHIN THE HELT

2473
01:31:12,920 --> 01:31:14,120
CARE SYSTEM, SO THAT'S WHEN THE

2474
01:31:14,120 --> 01:31:15,480
PATIENT IS IN THE SYSTEM BUT SO

2475
01:31:15,480 --> 01:31:17,240
MANY PEOPLE DON'T GET IN THE

2476
01:31:17,240 --> 01:31:17,480
SYSTEM.

2477
01:31:17,480 --> 01:31:22,000
THEY DON'T GET IN THE SYSTEM

2478
01:31:22,000 --> 01:31:22,680
EARLY ENOUGH, RIGHT?

2479
01:31:22,680 --> 01:31:23,800
THEY'RE COMING IN WITH LATE

2480
01:31:23,800 --> 01:31:25,680
STAGE DISEASE AND I THINK NA'S

2481
01:31:25,680 --> 01:31:28,120
AN IMPORTANT ASPECTS TO REDUCE

2482
01:31:28,120 --> 01:31:29,720
MORTALITY RATES, AND I KNOW IT

2483
01:31:29,720 --> 01:31:31,960
MIGHT BE PREMATURE TO HAVE THESE

2484
01:31:31,960 --> 01:31:33,600
DISCUSSIONS BUT I JUST THINK,

2485
01:31:33,600 --> 01:31:35,720
YOU KNOW MAYBE WE NEED TO MOVE A

2486
01:31:35,720 --> 01:31:37,920
LITTLE BIT OUTSIDE OF THE BOX AS

2487
01:31:37,920 --> 01:31:41,160
WE THINK ABOUT THE NEXT STEPS.

2488
01:31:41,160 --> 01:31:44,680
>> JOHN, YOU ARE PREACHING
TO

2489
01:31:44,680 --> 01:31:47,200
THE CHOIR.

2490
01:31:47,200 --> 01:31:51,560
WE ARE LOOKING AT HOW WE CAN

2491
01:31:51,560 --> 01:31:52,920
HELP WITH IMPLEMENTATION

2492
01:31:52,920 --> 01:31:54,880
RESEARCH BECAUSE MY PERSPECTIVE

2493
01:31:54,880 --> 01:32:00,120
IS THAT THE BIDEN ADMINISTRATION

2494
01:32:00,120 --> 01:32:01,160
GOALS ARE ASPIRATIONAL AND OUR

2495
01:32:01,160 --> 01:32:05,240
JOB IS TO TRY TO MAKE THEM

2496
01:32:05,240 --> 01:32:06,800
FEASIBLE AND TO ESSENTIALLY

2497
01:32:06,800 --> 01:32:10,600
EXPRESS HOW WE MIGHT BE ABLE TO

2498
01:32:10,600 --> 01:32:11,360
DO THAT.

2499
01:32:11,360 --> 01:32:13,320
>> AND I THINK ALSO JOHN,
YOU

2500
01:32:13,320 --> 01:32:15,720
KNOW THE PROCESSES BY WHICH WE

2501
01:32:15,720 --> 01:32:18,640
CHANGE STANDARD OF CARE ARE

2502
01:32:18,640 --> 01:32:20,000
PRETTY ARCANE TO BE HONEST SO IT

2503
01:32:20,000 --> 01:32:23,240
WOULD BE GOOD TO SEE THOSE PRO

2504
01:32:23,240 --> 01:32:24,480
SESESS REVISITED IN THIS NEW ERA

2505
01:32:24,480 --> 01:32:26,360
AND I THINK THERE ARE A LOT OF

2506
01:32:26,360 --> 01:32:27,840
THINGS THAT YOU MADE A REALLY

2507
01:32:27,840 --> 01:32:29,160
GOOD POINT THEY THINK ISN'T

2508
01:32:29,160 --> 01:32:30,320
REALLY COMING THROUGH IN TERMS

2509
01:32:30,320 --> 01:32:33,440
OF THE RHETORIC THAT WE SEE IN

2510
01:32:33,440 --> 01:32:35,880
WHAT'S GOING ON WITH THE MOON

2511
01:32:35,880 --> 01:32:36,080
SHOT.

2512
01:32:36,080 --> 01:32:38,320
DINA DID HAVE YOU A COMMENT?

2513
01:32:38,320 --> 01:32:39,960
>> NO, I JUST WANTED TO
FOLLOW

2514
01:32:39,960 --> 01:32:41,600
UP ON JOHN'S QUESTION ABOUT THE

2515
01:32:41,600 --> 01:32:45,720
PROCESS AND MAKE THE DISTINCTION

2516
01:32:45,720 --> 01:32:47,280
BETWEEN THE FIRST MOON SHOT AND

2517
01:32:47,280 --> 01:32:49,160
THE SUPER CHARGED MOON SHOT.

2518
01:32:49,160 --> 01:32:51,360
THE MOON SHOT 1.0, IF YOU WILL

2519
01:32:51,360 --> 01:32:55,240
WAS REALLY VERY FOCUSED ON

2520
01:32:55,240 --> 01:32:55,880
ACCELERATING CANCER RESEARCH, IN

2521
01:32:55,880 --> 01:32:57,840
THOSE AREAS THAT COULD BE

2522
01:32:57,840 --> 01:33:01,480
ACCELERATED AND SO THE BLUE

2523
01:33:01,480 --> 01:33:04,040
RIBBON PANEL WAS ASSEMBLED TO

2524
01:33:04,040 --> 01:33:06,280
HELP DEFINE WHAT THOSE AREAS

2525
01:33:06,280 --> 01:33:08,880
WERE AND THEN WE'VE BEEN ACTING

2526
01:33:08,880 --> 01:33:12,360
ON THAT EVER SINCE.

2527
01:33:12,360 --> 01:33:13,520
IMPLEMENTATION SCIENCE WAS A

2528
01:33:13,520 --> 01:33:15,160
LARGE PIECE OF THAT BUT IT

2529
01:33:15,160 --> 01:33:17,560
WASN'T THE ONLY PIECE AND I

2530
01:33:17,560 --> 01:33:19,480
THINK WITH THE SUPERCHARGED MOON

2531
01:33:19,480 --> 01:33:21,360
SHOT WE'RE SEEING A SHIFT MUCH

2532
01:33:21,360 --> 01:33:24,400
MORE TO THE IMPLEMENTATION

2533
01:33:24,400 --> 01:33:25,480
SCIENCE, THE ISSUES OF

2534
01:33:25,480 --> 01:33:26,880
HEALTHCARE DELIVERY SO THAT I

2535
01:33:26,880 --> 01:33:30,560
THINK MUCH OF IT WILL BE BEYOND

2536
01:33:30,560 --> 01:33:32,040
NCI AND FDA RESEARCH, ALTHOUGH

2537
01:33:32,040 --> 01:33:34,200
WE WILL BE AN INTEGRAL PART OF

2538
01:33:34,200 --> 01:33:35,920
IT AND OBVIOUSLY HAVING TO LEAD,

2539
01:33:35,920 --> 01:33:41,960
SO THE RESEARCH COMPONENT.

2540
01:33:41,960 --> 01:33:43,680
>> SO, JOHN, I THINK IT'S

2541
01:33:43,680 --> 01:33:45,680
INTERESTING, EVERYONE, I KNOW

2542
01:33:45,680 --> 01:33:46,720
THE ADVOCACY COMMUNITIES ARE

2543
01:33:46,720 --> 01:33:47,800
PAYING GREAT ATTENTION TO THIS

2544
01:33:47,800 --> 01:33:48,160
NOW.

2545
01:33:48,160 --> 01:33:49,920
THE OTHER THING THEY'RE PAYING

2546
01:33:49,920 --> 01:33:51,680
ATTENTION TO IS THIS ISSUE OF A

2547
01:33:51,680 --> 01:33:53,360
NUMBER OF GRANTS THAT NCI'S

2548
01:33:53,360 --> 01:33:57,800
RECEIVING AND CONTINUES TO

2549
01:33:57,800 --> 01:33:59,280
RECEIVE VERSUS, AND I'M NOT

2550
01:33:59,280 --> 01:34:02,880
SAYING THIS WITH ANY TERRITORIAL

2551
01:34:02,880 --> 01:34:04,080
INTENT BUT YOU KNOW IT'S

2552
01:34:04,080 --> 01:34:05,280
PROBABLY 10 TIMES IN MANY CASES

2553
01:34:05,280 --> 01:34:06,840
WHAT SOME OF THESE OTHER GROWNS

2554
01:34:06,840 --> 01:34:08,600
ACTUALLY RECEIVE AND WE HAVE TO

2555
01:34:08,600 --> 01:34:09,560
ACKNOWLEDGE THAT AT SOME POINT.

2556
01:34:09,560 --> 01:34:11,280
WE HAVE A COMMUNITY, AN

2557
01:34:11,280 --> 01:34:13,040
ENTERPRISE THAT WE BUILT THAT IS

2558
01:34:13,040 --> 01:34:14,440
QUITE WILLING AND READY TO

2559
01:34:14,440 --> 01:34:17,800
REALLY GO TO WORK TO CHANGE

2560
01:34:17,800 --> 01:34:18,600
THESE PARADIGMS, BUT YOU KNOW

2561
01:34:18,600 --> 01:34:20,520
THEY HAVE TO HAVE RESIEWRSS AND

2562
01:34:20,520 --> 01:34:21,600
SO THIS IS CERTAINLY ONLY 1

2563
01:34:21,600 --> 01:34:23,120
SOURCE OF THEM, BUT IT'S A BIG

2564
01:34:23,120 --> 01:34:24,120
WOB.

2565
01:34:24,120 --> 01:34:25,000
AND SO I'M--I'M A LITTLE

2566
01:34:25,000 --> 01:34:28,160
CONCERNED RIGHT NOW THAT WE, YOU

2567
01:34:28,160 --> 01:34:30,400
KNOW THAT--WE HAVE GOTTEN THE

2568
01:34:30,400 --> 01:34:31,480
ATTENTION THOUGH OF FOLKS OUT

2569
01:34:31,480 --> 01:34:33,880
THERE WHO ARE ADVOCATING ON OUR

2570
01:34:33,880 --> 01:34:37,600
BEHALF AND YOU SEE THAT NOW, IN

2571
01:34:37,600 --> 01:34:39,040
THIS--IN THESE BUDGET TOURS THAT

2572
01:34:39,040 --> 01:34:40,080
PATRICK PRESENTED AND A LOT OF

2573
01:34:40,080 --> 01:34:42,080
IT HAS TO DO WITH MAKING CLEAR

2574
01:34:42,080 --> 01:34:44,920
THAT THESE PAY LINES ARE

2575
01:34:44,920 --> 01:34:46,640
SUFFERING BECAUSE PEOPLE HAVE

2576
01:34:46,640 --> 01:34:48,400
TALENT AND INTEREST IN APPLYING

2577
01:34:48,400 --> 01:34:50,600
TO NCI FOR SUPPORT, AND SO, YOU

2578
01:34:50,600 --> 01:34:53,320
KNOW IF WE PASS--IF WE PASS,

2579
01:34:53,320 --> 01:34:54,680
THEN,S YOU KNOW A LOT OF YOUNG

2580
01:34:54,680 --> 01:34:56,680
PEOPLE ARE GOING TO GO TO

2581
01:34:56,680 --> 01:34:57,600
ANOTHER--YOU KNOW THEY'RE GOING

2582
01:34:57,600 --> 01:34:59,400
TO OPEN A BAKERY OR SOMETHING.

2583
01:34:59,400 --> 01:35:01,800
SO NOT QUITE SURE WHAT THEY'LL

2584
01:35:01,800 --> 01:35:03,800
DO BUT THEY'RE LOOKING FOR WORK

2585
01:35:03,800 --> 01:35:05,160
OBVIOUSLY AND IT'S REALLY SAD.

2586
01:35:05,160 --> 01:35:08,120
I JUST REALLY WANT US TO DO MORE

2587
01:35:08,120 --> 01:35:11,280
ABOUT THIS.

2588
01:35:11,280 --> 01:35:13,000
SO, OTHER QUESTIONS?

2589
01:35:13,000 --> 01:35:13,440
YES, KAREN?

2590
01:35:13,440 --> 01:35:16,240
>> YES, I JUST WANTED TO
GO BACK

2591
01:35:16,240 --> 01:35:18,360
TO THIS ISSUE ABOUT CANCER

2592
01:35:18,360 --> 01:35:20,000
DISPARITIES AND 1 OF THE THINGS

2593
01:35:20,000 --> 01:35:23,520
THAT WAS MENTIONED IS, YOU KNOW

2594
01:35:23,520 --> 01:35:24,240
THAT ACCESS ISSUES.

2595
01:35:24,240 --> 01:35:25,760
WE CAN FUND ALL THE

2596
01:35:25,760 --> 01:35:26,480
IMPLEMENTATION SCIENCE THAT WE

2597
01:35:26,480 --> 01:35:28,520
WANT TO BUT IF PEOPLE DON'T HAVE

2598
01:35:28,520 --> 01:35:30,120
THE INSURANCE, THE RIGHT

2599
01:35:30,120 --> 01:35:31,160
INSURANCE TO ACCESS THE

2600
01:35:31,160 --> 01:35:32,160
HEALTHCARE, THAT'S A PROBLEM,

2601
01:35:32,160 --> 01:35:32,400
RIGHT?

2602
01:35:32,400 --> 01:35:34,360
AND I UNDERSTAND THAT THAT'S NOT

2603
01:35:34,360 --> 01:35:36,120
WHAT THE NCI DOES AND I THINK WE

2604
01:35:36,120 --> 01:35:37,960
HAVE TO BE VERY CLEAR MINDED TO

2605
01:35:37,960 --> 01:35:40,160
TELL PEOPLE, THE NCI FUNDS

2606
01:35:40,160 --> 01:35:41,440
RESEARCH, RIGHT?

2607
01:35:41,440 --> 01:35:42,040
INCLUDING IMPLEMENTATION

2608
01:35:42,040 --> 01:35:43,920
RESEARCH, BUT ALSO PROVIDES

2609
01:35:43,920 --> 01:35:44,760
DOLLARS TO COMPREHENSIVE CANCER

2610
01:35:44,760 --> 01:35:46,880
CENTERS AND THERE ARE SO MANY

2611
01:35:46,880 --> 01:35:47,680
COMPREHENSIVE CANCER CENTERS

2612
01:35:47,680 --> 01:35:49,080
THAT DO NOT ACCEPT MEDICAID AND

2613
01:35:49,080 --> 01:35:51,520
THAT'S SOMETHING THAT WE NEED TO

2614
01:35:51,520 --> 01:35:52,480
THINK COLLECTIVELY ABOUT, ABOUT

2615
01:35:52,480 --> 01:35:54,360
HOW DO WE DO THAT?

2616
01:35:54,360 --> 01:35:55,320
WHAT'S THE POLICY LEVERAGE WE

2617
01:35:55,320 --> 01:35:57,040
CAN PULL THAT CAN REALLY HELP TO

2618
01:35:57,040 --> 01:35:58,560
MAKE SURE THAT IF WE ARE GOING

2619
01:35:58,560 --> 01:36:00,440
TO FUND RESEARCH TO

2620
01:36:00,440 --> 01:36:02,040
INSTITUTIONS, THAT THOSE SAME

2621
01:36:02,040 --> 01:36:04,240
INSTITUTIONS OPEN THEIR DOORS TO

2622
01:36:04,240 --> 01:36:05,160
EVERYONE OTHERWISE THOSE

2623
01:36:05,160 --> 01:36:10,280
DISPARITIES WILL CONTINUE TO

2624
01:36:10,280 --> 01:36:11,000
WIDEN.

2625
01:36:11,000 --> 01:36:11,800
>> THAT'S AN EXCELLENT
POINT AND

2626
01:36:11,800 --> 01:36:14,720
1 THING YOU WILL NOTE WHEN THE

2627
01:36:14,720 --> 01:36:15,360
BUDGET'S--ACTUALLY PATRICK MAY

2628
01:36:15,360 --> 01:36:17,400
KNOW ABOUT THIS BUT I KNOW

2629
01:36:17,400 --> 01:36:19,040
THERE'S A SIGNIFICANT INCREASE

2630
01:36:19,040 --> 01:36:20,840
IN THE 2023 BUDGET, I BELIEVE

2631
01:36:20,840 --> 01:36:23,760
FOR CDC THIS YEAR, AND CDC IN

2632
01:36:23,760 --> 01:36:25,080
PARTNERSHIP OFTEN WITH NCI IN

2633
01:36:25,080 --> 01:36:27,040
THE PAST HAS TRIED TO ADDRESS

2634
01:36:27,040 --> 01:36:29,080
JUST THIS ISSUE.

2635
01:36:29,080 --> 01:36:31,560
YOU RECALL THE ISSUE ON

2636
01:36:31,560 --> 01:36:33,320
SCREENING AND IT WERE BREAST

2637
01:36:33,320 --> 01:36:35,280
CANCER YEARS AGO, YOU KNOW WE

2638
01:36:35,280 --> 01:36:36,560
GOT EVERYBODY'S ATTENTION TO

2639
01:36:36,560 --> 01:36:39,200
SCREENING BUT NO 1 WANTED TO PAY

2640
01:36:39,200 --> 01:36:40,520
FOR IT.

2641
01:36:40,520 --> 01:36:41,680
SO ADVOCATES WENT BACK TO

2642
01:36:41,680 --> 01:36:42,880
CONGRESS AND ESSENTIALLY GOT

2643
01:36:42,880 --> 01:36:46,200
THAT BILL PASSED BUT, I THINK

2644
01:36:46,200 --> 01:36:47,440
YOU'RE ABSOLUTELY RIGHT.

2645
01:36:47,440 --> 01:36:49,200
IT'S VERY--WE KNOW IT'S A HARD

2646
01:36:49,200 --> 01:36:49,560
PROBLEM, RIGHT?

2647
01:36:49,560 --> 01:36:50,920
BUT YOU KNOW THERE ARE SOLUTIONS

2648
01:36:50,920 --> 01:36:53,520
TO THIS PROBLEM, WE SHOULD GET

2649
01:36:53,520 --> 01:36:54,000
ON WITH IT.

2650
01:36:54,000 --> 01:36:55,880
SO THANK YOU FOR THAT.

2651
01:36:55,880 --> 01:36:59,680
ANY OTHER COMMENTS ON THE

2652
01:36:59,680 --> 01:36:59,920
BUDGET?

2653
01:36:59,920 --> 01:37:04,720
SO I'M ALWAYS LOOKING FOR OTHER

2654
01:37:04,720 --> 01:37:08,120
OPPORTUNITIES AS WELL BECAUSE

2655
01:37:08,120 --> 01:37:09,080
NCI SUBJECT THE ONLY SOURCE OF

2656
01:37:09,080 --> 01:37:10,760
FUNDING AND EVERY TIME WE MAKE

2657
01:37:10,760 --> 01:37:12,120
AN INVESTMENT, IT RIEWCIALLY

2658
01:37:12,120 --> 01:37:14,160
ALLOWS THAT INVESTMENT TO

2659
01:37:14,160 --> 01:37:16,600
MULTIPLY BUT I WAS CURIOUS

2660
01:37:16,600 --> 01:37:20,200
PATRICK AND IF MK MIGHT SAY

2661
01:37:20,200 --> 01:37:22,640
SOMETHING ABOUT THIS PACT ACT,

2662
01:37:22,640 --> 01:37:23,840
PACT ACT, PASSED JUST 2 WEEKS

2663
01:37:23,840 --> 01:37:24,120
AGO.

2664
01:37:24,120 --> 01:37:28,320
AND THIS IS AN ACT, IF YOU

2665
01:37:28,320 --> 01:37:29,280
WEREN'T PAYING ATTENTION, IT'S

2666
01:37:29,280 --> 01:37:30,880
IT'S A REALLY INTERESTING

2667
01:37:30,880 --> 01:37:34,880
APPROACH, I THINK FOR VETERANS

2668
01:37:34,880 --> 01:37:37,520
WHO WERE ACTUALLY, I THINK

2669
01:37:37,520 --> 01:37:40,520
EXPOSED TO ANYTHING, ANYWHERE

2670
01:37:40,520 --> 01:37:43,160
ESPECIALLY IN IRAQ, IRAN, ET

2671
01:37:43,160 --> 01:37:44,160
CETERA ALL THOSE TERRIBLE AREAS

2672
01:37:44,160 --> 01:37:45,640
OF THE WORLD THAT HAVE, YOU KNOW

2673
01:37:45,640 --> 01:37:47,360
WHERE THEY'VE BEEN EXPOSED TO

2674
01:37:47,360 --> 01:37:49,840
BURN PITS AND LOTS AND LOTS OF

2675
01:37:49,840 --> 01:37:53,160
OTHER TERRIBLE TOXIC MATERIALS.

2676
01:37:53,160 --> 01:37:58,920
THAT ACT IS ACTUALLY GOING TO

2677
01:37:58,920 --> 01:37:59,720
GUARANTEE VETERANS ESSENTIALLY

2678
01:37:59,720 --> 01:38:03,880
CARE BUT IT ALSO IS PROVIDING, I

2679
01:38:03,880 --> 01:38:05,480
THINK FUNDING FOR RESEARCH AND I

2680
01:38:05,480 --> 01:38:08,280
MEAN IT KIND OF OPENS UP A WHOLE

2681
01:38:08,280 --> 01:38:11,160
NEW OR REVISITS AN AREA OF

2682
01:38:11,160 --> 01:38:12,800
CANCER RESEARCH THAT'S BEEN KIND

2683
01:38:12,800 --> 01:38:13,640
OF LANGUISHING FOR YEARS AND

2684
01:38:13,640 --> 01:38:16,120
THAT IS, YOU KNOW COMPLEX

2685
01:38:16,120 --> 01:38:18,240
CARCINOGENS THAT PEOPLE ARE

2686
01:38:18,240 --> 01:38:20,560
EXPOSED TO, ESPECIALLY FROM

2687
01:38:20,560 --> 01:38:21,800
THESE PARTICULAR MILITARY

2688
01:38:21,800 --> 01:38:24,680
ACTIVITIES AND SO, I DON'T KNOW

2689
01:38:24,680 --> 01:38:25,640
PATRICK IF WE KNOW ANYTHING

2690
01:38:25,640 --> 01:38:28,960
ABOUT THAT ACT IN TERMS OF HOW

2691
01:38:28,960 --> 01:38:32,880
IT MIGHT IMPACT US?

2692
01:38:32,880 --> 01:38:35,640
I KNOW THERE WAS A MEETING, I

2693
01:38:35,640 --> 01:38:38,600
KNOW THAT DR. SCHRIEBER CONVENED

2694
01:38:38,600 --> 01:38:40,520
A FEW WEEKS AGO AND NCI WAS

2695
01:38:40,520 --> 01:38:41,720
REPRESENTED THERE SO I DON'T

2696
01:38:41,720 --> 01:38:45,120
KNOW IF WE KNOW ANYTHING MORE

2697
01:38:45,120 --> 01:38:46,920
ABOUT IT OR NOT.

2698
01:38:46,920 --> 01:38:48,520
>> AND SO, I THINK I
UNDERSTAND

2699
01:38:48,520 --> 01:38:50,000
WHAT YOU'RE SAYING, IT DOESN'T

2700
01:38:50,000 --> 01:38:54,920
HAVE A DIRECT IMPACT ON US,

2701
01:38:54,920 --> 01:38:58,600
HOWEVER, IT DOES IMPACT AN

2702
01:38:58,600 --> 01:39:04,600
IMPORTANT FIELD OF CANCER RISK

2703
01:39:04,600 --> 01:39:05,080
AND POTENTIALLY CANCER

2704
01:39:05,080 --> 01:39:06,920
PREVENTION AND MANY OTHER

2705
01:39:06,920 --> 01:39:07,160
THINGS.

2706
01:39:07,160 --> 01:39:08,920
SO AND OF COURSE, THIS IS AN

2707
01:39:08,920 --> 01:39:11,560
AUTHORIZATION ACT AND WE NEED TO

2708
01:39:11,560 --> 01:39:12,880
LOOK TO THE DEFENSE

2709
01:39:12,880 --> 01:39:14,560
APPROPRIATIONS BILL FOR

2710
01:39:14,560 --> 01:39:17,880
RESOURCES, BUT I DO KNOW THAT

2711
01:39:17,880 --> 01:39:21,200
EVEN PRIOR TO THIS BILL, IN

2712
01:39:21,200 --> 01:39:23,360
GETTING ENACTED, THERE WAS A

2713
01:39:23,360 --> 01:39:29,120
STEADY INCREASE IN FUNDING FOR

2714
01:39:29,120 --> 01:39:32,280
THIS FIELD WITHIN BOTH THE VA

2715
01:39:32,280 --> 01:39:34,800
AND THE DEPARTMENT OF DEFENSE.

2716
01:39:34,800 --> 01:39:38,320
THE DEFENSE OF DEFENSE HAS A

2717
01:39:38,320 --> 01:39:40,160
CANCER RESEARCH PROGRAM AND THIS

2718
01:39:40,160 --> 01:39:42,840
WAS ADDED AND ADDITIONAL

2719
01:39:42,840 --> 01:39:47,480
SPECIFIC DOLLARS WERE PUT INTO

2720
01:39:47,480 --> 01:39:51,240
THEIR RESOURCE POOL FOR CANCER

2721
01:39:51,240 --> 01:39:56,200
RESEARCH STARTING IT MAY HAVE

2722
01:39:56,200 --> 01:39:57,360
PREIDATED FISCAL YEAR 2021 BUT I

2723
01:39:57,360 --> 01:40:02,720
WATCHED IT GROW AND GROW AGAIN

2724
01:40:02,720 --> 01:40:05,240
IN 2022 SO AT NCI IS LOOKING TO

2725
01:40:05,240 --> 01:40:09,840
PARTNER WITH THE VA AND THE

2726
01:40:09,840 --> 01:40:11,840
D.O.D., I'M NOT SURE HOW THAT'S

2727
01:40:11,840 --> 01:40:14,240
GOING TO EVOLVE, DR. PHIL CASTLE

2728
01:40:14,240 --> 01:40:16,520
IS 1 OF THE 1S ENGAGED IT TRYING

2729
01:40:16,520 --> 01:40:22,040
TO BE SUPPORTIVE, BE

2730
01:40:22,040 --> 01:40:22,720
COLLABORATIVE, AND LEVERAGE

2731
01:40:22,720 --> 01:40:24,880
MUTUALLY THE RESOURCES AND

2732
01:40:24,880 --> 01:40:27,960
CAPABILITIES OF ALL 3 AGENCIES.

2733
01:40:27,960 --> 01:40:29,960
IT'S AN AREA TO WATCH AND AN

2734
01:40:29,960 --> 01:40:31,680
AREA OF OPPORTUNITY IS

2735
01:40:31,680 --> 01:40:32,600
FUNDAMENTALLY WHAT YOU'RE

2736
01:40:32,600 --> 01:40:32,840
SAYING.

2737
01:40:32,840 --> 01:40:34,680
>> I THINK IT'S AN
OPPORTUNITY

2738
01:40:34,680 --> 01:40:36,040
BUT IT'S ALSO REALLY INTERESTING

2739
01:40:36,040 --> 01:40:37,240
OPPORTUNITY IN TERMS OF WHERE WE

2740
01:40:37,240 --> 01:40:39,000
ARE.

2741
01:40:39,000 --> 01:40:40,280
I MEAN MOLECULAR CAR SIN O

2742
01:40:40,280 --> 01:40:42,600
GENESIS WILL BE, YOU KNOW REALLY

2743
01:40:42,600 --> 01:40:43,480
REQUIRED HERE IN APPLYING SO

2744
01:40:43,480 --> 01:40:45,000
MANY OF THE THINGS THAT WE KNOW

2745
01:40:45,000 --> 01:40:46,920
HOW TO DO NOW THAT WE WOULDN'T

2746
01:40:46,920 --> 01:40:48,680
HAVE KNOWN HOW TO DO 10 YEARS

2747
01:40:48,680 --> 01:40:54,880
AGO AND I'M PRETTY SURE THAT

2748
01:40:54,880 --> 01:40:56,720
DR. SCHREIBER WOULD LIKE TO

2749
01:40:56,720 --> 01:40:58,120
ATTRACT PLANE OF OUR EXTRAMURAL

2750
01:40:58,120 --> 01:40:58,760
INVESTIGATORS TO WORK ON

2751
01:40:58,760 --> 01:40:59,520
PROGRAMS LOAMACYIC THIS BECAUSE

2752
01:40:59,520 --> 01:41:01,360
THIS WILL BE VERY SOPHISTICATED

2753
01:41:01,360 --> 01:41:03,920
SCIENCE BECAUSE THESE ARE VERY,

2754
01:41:03,920 --> 01:41:04,960
VERY COMPLEX MIXTURES THAT THESE

2755
01:41:04,960 --> 01:41:06,360
FOLKS HAVE BEEN EXPOSED TO.

2756
01:41:06,360 --> 01:41:09,320
SO WE NEED TO LACK AT THAT AND I

2757
01:41:09,320 --> 01:41:13,240
THINK, I THINK DR. SCHRIEBER IS

2758
01:41:13,240 --> 01:41:15,160
ON THE NCAB AS OUR VA

2759
01:41:15,160 --> 01:41:16,240
REPRESENTATIVE SO AT IN POINT IT

2760
01:41:16,240 --> 01:41:17,440
MIGHT BE GOOD TO BRIEF US ON

2761
01:41:17,440 --> 01:41:22,080
THIS IN TERMS OF WHAT HIS PLANS

2762
01:41:22,080 --> 01:41:22,640
ARE.

2763
01:41:22,640 --> 01:41:23,920
I HAD A--SO LET ME JUST MAKE

2764
01:41:23,920 --> 01:41:26,880
SURE THAT WE HAVE OTHER

2765
01:41:26,880 --> 01:41:32,200
QUESTIONS FROM THE SUBCOMMITTEE.

2766
01:41:32,200 --> 01:41:33,960
SO I HAVE A COUPLE QUESTIONS

2767
01:41:33,960 --> 01:41:35,280
THAT CAME IN FROM ME PATRICK AND

2768
01:41:35,280 --> 01:41:36,520
I DON'T WANT TO PUT YOU ON THE

2769
01:41:36,520 --> 01:41:37,960
SPOT SO YOU CAN PASS BECAUSE I

2770
01:41:37,960 --> 01:41:43,600
DEPARTMENT KNOW THAT I WOULD

2771
01:41:43,600 --> 01:41:44,040
HAVE THESE.

2772
01:41:44,040 --> 01:41:49,440
SO SOMEBODY ASKED ME AFTER OUR

2773
01:41:49,440 --> 01:41:53,080
LAST MEETING HOW DO WE NCI

2774
01:41:53,080 --> 01:41:54,120
CLASSIFY RESEARCH WHEN PEOPLE

2775
01:41:54,120 --> 01:41:56,080
ARE LOOKING TO FIND OUT HOW MUCH

2776
01:41:56,080 --> 01:41:58,200
IS SPENT ON EACH AREA AND ON

2777
01:41:58,200 --> 01:42:00,080
EACH, YOU KNOW PROSTATE CANCER,

2778
01:42:00,080 --> 01:42:01,640
BREAST CANCER, WHAT HAVE YOU

2779
01:42:01,640 --> 01:42:04,120
INDIVIDUALLY, HOW DO WE MAKE

2780
01:42:04,120 --> 01:42:04,680
THAT DETERMINATION?

2781
01:42:04,680 --> 01:42:10,840
IT'S A COMPLICATED ANSWER, I

2782
01:42:10,840 --> 01:42:11,160
KNOW, PATRICK.

2783
01:42:11,160 --> 01:42:13,240
>>  WELL, THERE ARE A
COUPLE OF

2784
01:42:13,240 --> 01:42:14,800
RESOURCES FOR IDENTIFYING THE

2785
01:42:14,800 --> 01:42:19,400
DOLLARS WE HAVE IN AREAS OF

2786
01:42:19,400 --> 01:42:19,680
RESEARCH.

2787
01:42:19,680 --> 01:42:25,000
NCI MANAGED 1 AND NIH MANAGES

2788
01:42:25,000 --> 01:42:26,600
ANOTHER AND NIH MANAGES IT

2789
01:42:26,600 --> 01:42:28,280
GLOBALLY BUT OF COURSE IT PICKS

2790
01:42:28,280 --> 01:42:32,200
UP ON CANCER GLOBALLY FOR ALL

2791
01:42:32,200 --> 01:42:34,040
NIH AND YOU KNOW I CAN FOLLOW UP

2792
01:42:34,040 --> 01:42:39,320
AND GET THE WEB LINKS TO THOSE

2793
01:42:39,320 --> 01:42:41,960
RESOURCES BUT THERE ARE

2794
01:42:41,960 --> 01:42:42,840
ESTABLISHED CAN COMPLEX

2795
01:42:42,840 --> 01:42:47,360
ALGORITHMS THAT WE WILL LOOK AT,

2796
01:42:47,360 --> 01:42:49,920
ABSTRACTS OF RESEARCH PROPOSALS

2797
01:42:49,920 --> 01:42:57,120
THAT WE FUND AND DETERMINE THE

2798
01:42:57,120 --> 01:42:59,000
WAITING IF YOU WILL, THE AREAS

2799
01:42:59,000 --> 01:43:04,400
OF RESEARCH THAT A PARTICULAR

2800
01:43:04,400 --> 01:43:05,240
AWARDED APPLICATION SEEKS TO

2801
01:43:05,240 --> 01:43:11,120
FUND AND THERE'S A FULL ENTIRE

2802
01:43:11,120 --> 01:43:12,520
PROCESS THAT MY OFFICE DOESN'T

2803
01:43:12,520 --> 01:43:14,120
TOUCH BUT WE DO GET FAMILIAR

2804
01:43:14,120 --> 01:43:15,720
WITH AND WE GET QUESTIONS FROM

2805
01:43:15,720 --> 01:43:17,880
TIME TO TIME AND WE REFER THEM

2806
01:43:17,880 --> 01:43:19,160
TO THOSE STANDING RESOURCES OF

2807
01:43:19,160 --> 01:43:20,240
INFORMATION, THIS HAS BEEN GOING

2808
01:43:20,240 --> 01:43:24,160
ON FOR MORE THAN A DECADE, AND

2809
01:43:24,160 --> 01:43:25,720
IT'S EVER GREEN, WE GET MORE

2810
01:43:25,720 --> 01:43:30,880
ROBUST, WHICH WE TRY TO IMPROVE

2811
01:43:30,880 --> 01:43:31,920
OUR PAIBILITY TO BE MORE

2812
01:43:31,920 --> 01:43:35,280
SPECIFIC AND FROM TIME TO TIME

2813
01:43:35,280 --> 01:43:38,640
WE ADD NEW CATEGORIES AS NEW

2814
01:43:38,640 --> 01:43:43,360
CATEGORIES EMERGE SUCH AS LIKE

2815
01:43:43,360 --> 01:43:45,560
CATEGORY WE JUST CITED WITH THE

2816
01:43:45,560 --> 01:43:46,360
PACT BILL.

2817
01:43:46,360 --> 01:43:48,120
SO THAT MIGHT NOT EVEN BEEN

2818
01:43:48,120 --> 01:43:50,440
FORMED ABOUT 5 OR 7 YEARS AGO

2819
01:43:50,440 --> 01:43:52,560
EXCEPT BY A FEW ADVANCED

2820
01:43:52,560 --> 01:43:54,880
THINKERS, THAT'S HOW IT WORKS.

2821
01:43:54,880 --> 01:43:55,840
CAN'T BE MUCH MORE SPECIFIC THAN

2822
01:43:55,840 --> 01:43:57,600
THAT BUT I CAN CERTAINLY FOLLOW

2823
01:43:57,600 --> 01:44:00,160
UP AND GET THOSE LINKS PASSED ON

2824
01:44:00,160 --> 01:44:01,800
TO THE MEMBERS OF THE

2825
01:44:01,800 --> 01:44:04,240
SUBCOMMITTEE AND MAYBE WE COULD

2826
01:44:04,240 --> 01:44:06,040
I GUESS IF IT'S ACCEPTABLE, WE

2827
01:44:06,040 --> 01:44:11,680
COULD PUT THOSE IN THE MINUTES.

2828
01:44:11,680 --> 01:44:14,320
>> THAT WOULD BE HELPFUL,
I

2829
01:44:14,320 --> 01:44:15,320
GUESS MORE PEOPLE--WHEN THE

2830
01:44:15,320 --> 01:44:16,600
SYSTEM WAS DEVELOPED, I KNOW

2831
01:44:16,600 --> 01:44:17,920
IT'S A PRETTY COMPLEX SYSTEM BUT

2832
01:44:17,920 --> 01:44:19,320
IF YOU'RE LOOKING UP TO SEE HOW

2833
01:44:19,320 --> 01:44:20,720
MUCH YOUR PARTICULAR AREA OF

2834
01:44:20,720 --> 01:44:25,800
INTEREST IS BEING FUNDED, THERE

2835
01:44:25,800 --> 01:44:31,880
IS A MECHANISM THERE. 

2836
01:44:31,880 --> 01:44:33,200
SO 1 OTHER QUESTION AND THIS MAY

2837
01:44:33,200 --> 01:44:34,600
BE SOMETHING FOR A LATER

2838
01:44:34,600 --> 01:44:35,920
SUBCOMMITTEE BUT YOU KNOW, HOW

2839
01:44:35,920 --> 01:44:38,360
DO WE AT NCI DETERMINE THE

2840
01:44:38,360 --> 01:44:42,480
PERCENTAGE OF OUR BUDGET THAT

2841
01:44:42,480 --> 01:44:44,360
GOES INTO RFAs VERSUS

2842
01:44:44,360 --> 01:44:44,760
EVERYTHING ELSE?

2843
01:44:44,760 --> 01:44:46,680
SO I DON'T KNOW IF WE ARE

2844
01:44:46,680 --> 01:44:49,720
PREPARED TO ANSWER THAT, IF

2845
01:44:49,720 --> 01:44:51,360
THEY'RE--BECAUSE IT'S NOT

2846
01:44:51,360 --> 01:44:52,640
NECESSARILY PROCESSED BECAUSE

2847
01:44:52,640 --> 01:44:56,040
IT'S NOT NECESSARILY DEPENDENT

2848
01:44:56,040 --> 01:44:56,760
OPPORTUNITY DEPENDENT IS THERE

2849
01:44:56,760 --> 01:44:58,080
ANY WAY YOU WANT TO TRY TO

2850
01:44:58,080 --> 01:44:59,480
ANSWER IT NOW OR TRY TO THINK

2851
01:44:59,480 --> 01:45:00,640
ABOUT IT.

2852
01:45:00,640 --> 01:45:02,840
>> I STARTED OFF AND MAYBE

2853
01:45:02,840 --> 01:45:03,800
OTHERS IN LEADERSHIP WANT TO

2854
01:45:03,800 --> 01:45:05,000
JUMP IN BUT WE'RE VERY

2855
01:45:05,000 --> 01:45:07,840
CONSCIOUS, WE HAVE A VERY

2856
01:45:07,840 --> 01:45:09,960
CONCERTED EFFORT TO INSURE THAT

2857
01:45:09,960 --> 01:45:13,920
THERE'S A PROPER BALANCE BETWEEN

2858
01:45:13,920 --> 01:45:19,000
RFA AND INVESTIGATOR INITIATED

2859
01:45:19,000 --> 01:45:24,320
FUNDED RESEARCH AND WE MEET AND

2860
01:45:24,320 --> 01:45:25,280
WE SET THRESHOLDS.

2861
01:45:25,280 --> 01:45:27,120
WE PREFER NOT TO EXCEED A

2862
01:45:27,120 --> 01:45:31,200
CERTAIN AMOUNT OF OUR COMPETING

2863
01:45:31,200 --> 01:45:35,200
GRANTS POOL IN RFAs, WE--IT

2864
01:45:35,200 --> 01:45:36,840
DOES EXPAND AND CONTRACT AT LIKE

2865
01:45:36,840 --> 01:45:39,400
THE 1% LEVEL ACROSS THE YEARS,

2866
01:45:39,400 --> 01:45:43,080
SOMETIMES WITH 1% BELOW,

2867
01:45:43,080 --> 01:45:45,320
SOMETIMES, I APOLOGIZE, 1% ABOVE

2868
01:45:45,320 --> 01:45:48,880
OUR TARGETED THRESHOLD BASED

2869
01:45:48,880 --> 01:45:50,680
KNOW SOME URGENCY OR ANOTHER,

2870
01:45:50,680 --> 01:45:52,000
AND SO, THERE'S A FULL PROCESS

2871
01:45:52,000 --> 01:45:56,080
THERE THAT WE GO THROUGH EACH

2872
01:45:56,080 --> 01:45:59,720
YEAR TO, I GUESS IT'S A GOLDY

2873
01:45:59,720 --> 01:46:02,240
LOCKS AND THE 3 BEARS, NOT TOO

2874
01:46:02,240 --> 01:46:03,680
MUCH, NOT TOO LITTLE, JUST

2875
01:46:03,680 --> 01:46:07,720
RIGHT, IS WHAT WE STRIVE FOR.

2876
01:46:07,720 --> 01:46:09,320
>> THAT'S RIGHT.

2877
01:46:09,320 --> 01:46:11,400
SO DO YOU WANT TO COMENLT ON

2878
01:46:11,400 --> 01:46:11,600
THAT?

2879
01:46:11,600 --> 01:46:12,960
, YEAH, WHY DON'T I JUST SAY

2880
01:46:12,960 --> 01:46:16,320
THAT WE WANT TO MAKE SURE THAT

2881
01:46:16,320 --> 01:46:22,760
ON THE 1 HAND THERE ARE RFAs

2882
01:46:22,760 --> 01:46:23,880
WHEN IT IS CRITICALLY IMPORTANT

2883
01:46:23,880 --> 01:46:25,640
TO HAVE THEM AND I ALSO WANT TO

2884
01:46:25,640 --> 01:46:27,080
TELL PEOPLE BECAUSE WE'RE

2885
01:46:27,080 --> 01:46:29,120
TALKING ABOUT BUDGETED, THERE

2886
01:46:29,120 --> 01:46:33,400
ARE MANY RFAs THAT ARE OUTSIDE

2887
01:46:33,400 --> 01:46:36,560
THE RPG POOL BUT RFAs THAT ARE

2888
01:46:36,560 --> 01:46:41,720
WITHIN THE RPG POOL, WE AIM FOR

2889
01:46:41,720 --> 01:46:48,960
THEM TO BE ON THE ORDER OF

2890
01:46:48,960 --> 01:46:53,360
10-15% FORT RPG POOL FOR EACH

2891
01:46:53,360 --> 01:46:53,600
YEAR.

2892
01:46:53,600 --> 01:46:58,680
WE WORRY THAT IF WE GO ABOVE

2893
01:46:58,680 --> 01:47:02,080
THAT PERCENTAGE, THAT TRUE

2894
01:47:02,080 --> 01:47:04,520
INVESTIGATOR INITIATED RESEARCH

2895
01:47:04,520 --> 01:47:07,120
WILL BE FURTHER CURTAILED

2896
01:47:07,120 --> 01:47:08,640
BECAUSE ON THE 1 HAND, WE ARE

2897
01:47:08,640 --> 01:47:10,240
SIPPINGINALLING WE THINK THIS IS

2898
01:47:10,240 --> 01:47:12,960
IMPORTANT BUT ON THE RECOLLECT

2899
01:47:12,960 --> 01:47:14,920
HAND, THE PRINCIPLE PURPOSE OF

2900
01:47:14,920 --> 01:47:24,240
THE RPG POOL IS FOR INVESTIGATOR

2901
01:47:24,240 --> 01:47:25,160
INITIATED RESEARCH.

2902
01:47:25,160 --> 01:47:27,520
>> DINAH, YOU HAVE
ANYTHING TO

2903
01:47:27,520 --> 01:47:28,080
ADD?

2904
01:47:28,080 --> 01:47:28,800
>> ONLY A LITTLE.

2905
01:47:28,800 --> 01:47:32,640
I THINK WE USE RFAs VERY

2906
01:47:32,640 --> 01:47:35,880
THOUGHTFULLY AND THEY'RE MOSTLY

2907
01:47:35,880 --> 01:47:37,600
FOCUSED ON AREAS THAT ARE

2908
01:47:37,600 --> 01:47:39,320
EMERGING WITHIN OUR PORTFOLIO,

2909
01:47:39,320 --> 01:47:44,240
THAT WE REALLY THINK NEED TO BE

2910
01:47:44,240 --> 01:47:46,880
FACILITATED BY HAVING SET ASIDE

2911
01:47:46,880 --> 01:47:48,160
FUNDS BUT WE'RE VERY CAUTIOUS IN

2912
01:47:48,160 --> 01:47:50,240
USING THEM AS PATRICK SAID.

2913
01:47:50,240 --> 01:47:53,800
WE REVIEW THEM CRITICALLY AT

2914
01:47:53,800 --> 01:47:57,560
MULTIPLE LEVELS AND TRY TO KEEP

2915
01:47:57,560 --> 01:48:00,440
AS MUCH IN THE BUDGET FOR

2916
01:48:00,440 --> 01:48:03,400
INVESTIGATOR INITIATED RESEARCH

2917
01:48:03,400 --> 01:48:04,240
AS WE CAN.

2918
01:48:04,240 --> 01:48:07,600
>> I THINK EVERYONE KNOWS
THE

2919
01:48:07,600 --> 01:48:09,720
RFAs ARE REVIEWED WITH SOME

2920
01:48:09,720 --> 01:48:11,880
TENACITY BY THE BSA AND THEY

2921
01:48:11,880 --> 01:48:14,920
ALWAYS HAVE THINGS TO SAY ABOUT

2922
01:48:14,920 --> 01:48:16,720
THOSE, SO IT'S--MONEY IS ALWAYS

2923
01:48:16,720 --> 01:48:20,480
SPENT VERY WISELY IN THAT

2924
01:48:20,480 --> 01:48:20,960
REGARD.

2925
01:48:20,960 --> 01:48:22,680
SO 1 OTHER CAVEAT, NOW WE TALKED

2926
01:48:22,680 --> 01:48:27,120
ABOUT THIS LAST TIME BUT--EXCUSE

2927
01:48:27,120 --> 01:48:28,360
ME--BUT DOUG I WAS WONDERING

2928
01:48:28,360 --> 01:48:29,520
SINCE I HAVE YOU IF YOU COULD

2929
01:48:29,520 --> 01:48:33,520
SAY A BIT MORE ABOUT THIS.

2930
01:48:33,520 --> 01:48:34,240
THIS MULTIDETECTION OF CANCER

2931
01:48:34,240 --> 01:48:37,320
AND YOU KNOW WE HEARD FROM PHIL

2932
01:48:37,320 --> 01:48:39,480
KASES EDUCATIONALY ON THIS AND

2933
01:48:39,480 --> 01:48:42,800
WE'RE HEARING EVERYWHERE NOW

2934
01:48:42,800 --> 01:48:44,200
THAT STARTED OBVIOUSLY WITH

2935
01:48:44,200 --> 01:48:46,600
METHYLATION BUT NOW IT'S MOVED

2936
01:48:46,600 --> 01:48:49,400
INTO ALL ASPECTS OF RNA AND EVEN

2937
01:48:49,400 --> 01:48:51,720
ALL THE WAY BACK TO DNA AND

2938
01:48:51,720 --> 01:48:55,200
THEY'RE NOW, YOU KNOW A MILLION

2939
01:48:55,200 --> 01:48:59,000
COMPANIES THAT ARE FORMING THIS

2940
01:48:59,000 --> 01:49:00,440
REGARD, SO DO YOU THINK WE'RE

2941
01:49:00,440 --> 01:49:02,760
PREPARED FOR THIS, I GUESS IN

2942
01:49:02,760 --> 01:49:04,200
TERMS OF OUR INFRASTRUCTURE AND

2943
01:49:04,200 --> 01:49:05,920
GETTING BACK TO STANDARD OF

2944
01:49:05,920 --> 01:49:08,800
CARE, TO JOHNS COMMENT, HOW DO

2945
01:49:08,800 --> 01:49:11,440
YOU SEE THIS GOING?

2946
01:49:11,440 --> 01:49:11,960
I MEAN--

2947
01:49:11,960 --> 01:49:14,840
>> ANN ARE YOU REFERRING
TO THE

2948
01:49:14,840 --> 01:49:15,720
RESEARCH PART?

2949
01:49:15,720 --> 01:49:19,320
OR IT BECOMES STANDARD OF CARE

2950
01:49:19,320 --> 01:49:21,720
AND IS IT GOING TO BE THE WILD

2951
01:49:21,720 --> 01:49:22,040
WEST?

2952
01:49:22,040 --> 01:49:24,040
>> I DON'T KNOW AND I'M
JUST

2953
01:49:24,040 --> 01:49:24,960
WONDERING, I MENTIONED LAST TIME

2954
01:49:24,960 --> 01:49:27,200
THAT MAKE WE NEED A COMMITTEE OF

2955
01:49:27,200 --> 01:49:29,840
THE NCAB TO LOOK INTO THIS.

2956
01:49:29,840 --> 01:49:39,520
BUT I JUST WONDER WHAT YOU'RE

2957
01:49:39,520 --> 01:49:39,800
THINKING?

2958
01:49:39,800 --> 01:49:42,120
>> WELL, WE FEEL THAT
HAVING A

2959
01:49:42,120 --> 01:49:45,600
MORTALITY END POINT IS VERY

2960
01:49:45,600 --> 01:49:46,880
IMPORTANT.

2961
01:49:46,880 --> 01:49:48,800
THERE IS CONCERN THAT I MEAN WE

2962
01:49:48,800 --> 01:49:51,720
KNOW WE'RE GOING TO DETECT

2963
01:49:51,720 --> 01:49:53,040
ASYMPTOMATIC CANCERS, OKAY?

2964
01:49:53,040 --> 01:49:57,960
THE QUESTION IS, WILL WE EXTEND

2965
01:49:57,960 --> 01:50:00,400
LIFE? 

2966
01:50:00,400 --> 01:50:03,120
AND I THINK THAT NCI IS REALLY

2967
01:50:03,120 --> 01:50:05,840
GOING TO BE REQUIRED TO DO THAT.

2968
01:50:05,840 --> 01:50:11,160
WE ARE GOING TO DO THAT AS WELL

2969
01:50:11,160 --> 01:50:14,680
AS WE CAN, BUT, I THINK THAT WE

2970
01:50:14,680 --> 01:50:19,040
SEE THAT IT REQUIRES A LOT OF

2971
01:50:19,040 --> 01:50:23,840
INFRASTRUCTURE BECAUSE THE

2972
01:50:23,840 --> 01:50:24,840
TRIALS ARE LARGE.

2973
01:50:24,840 --> 01:50:26,120
BECAUSE, YOU KNOW, GOOD NEWS IS

2974
01:50:26,120 --> 01:50:33,400
MOST PEOPLE DON'T HAVE CANCER.

2975
01:50:33,400 --> 01:50:34,760
SO YOU HAVE TO SCREEN A LOT OF

2976
01:50:34,760 --> 01:50:36,520
PEOPLE IN ORDER TO DETECT A

2977
01:50:36,520 --> 01:50:38,000
REASONABLE NUMBER OF CANCERS SO

2978
01:50:38,000 --> 01:50:44,120
YOU THEN CAN SAY, WELL, HOW ARE

2979
01:50:44,120 --> 01:50:44,480
WE DOING?

2980
01:50:44,480 --> 01:50:46,280
IN ADDITION AS YOU POINT OUT

2981
01:50:46,280 --> 01:50:56,840
THERE ARE MULTIPLE PLATFORMS SO

2982
01:51:05,680 --> 01:51:07,040
IT REALLY BECOMES A BIG PROBLEM.

2983
01:51:07,040 --> 01:51:08,920
JOHN YOU ARE NODDING YOUR HEAD,

2984
01:51:08,920 --> 01:51:10,120
SO IT'S A BIG PROBLEM.

2985
01:51:10,120 --> 01:51:13,200
>> IT'S A BIG PROBLEM.

2986
01:51:13,200 --> 01:51:15,440
>> IT'S A BIG PROBLEM BUT
DO WE

2987
01:51:15,440 --> 01:51:16,680
ASSESSMENT TO STANDARDIZE OR DO

2988
01:51:16,680 --> 01:51:17,880
WE FALL INTO A SITUATION WHERE

2989
01:51:17,880 --> 01:51:20,800
THERE ARE GOING TO BE HOME BREW

2990
01:51:20,800 --> 01:51:21,720
LABORATORY DEVELOPED TESTS

2991
01:51:21,720 --> 01:51:24,280
VERSUS THOSE THAT MIGHT BE MORE

2992
01:51:24,280 --> 01:51:26,880
STANDARDIZED TESTS THROUGH A

2993
01:51:26,880 --> 01:51:27,680
SPECIFIC VENDORS AND IT'S GOING

2994
01:51:27,680 --> 01:51:37,680
TO BE A REALLY, REALLY

2995
01:51:37,680 --> 01:51:38,760
COMPLICATED SITUATION.

2996
01:51:38,760 --> 01:51:39,840
>> I THINK RARELY HAVE WE
SEEN

2997
01:51:39,840 --> 01:51:41,000
SOMETHING THAT COULD BE A

2998
01:51:41,000 --> 01:51:42,080
PARADIGM SHIFT AND WE HAVE TO

2999
01:51:42,080 --> 01:51:43,800
FIGURE THIS OUT AND I THINK WHAT

3000
01:51:43,800 --> 01:51:46,400
YOU'RE GOING TO DO HERE, DOUG IS

3001
01:51:46,400 --> 01:51:51,680
VULNERABLE IN TERMS OF WHAT HAS

3002
01:51:51,680 --> 01:51:53,400
TO BE DONE BUT I'M HOPING THAT

3003
01:51:53,400 --> 01:51:55,440
NCI GETS A LOT OF VISIBILITY FOR

3004
01:51:55,440 --> 01:51:56,840
DOING THE TRIALS BECAUSE I THINK

3005
01:51:56,840 --> 01:51:58,560
YOU'RE RIGHT, THE END POINT HERE

3006
01:51:58,560 --> 01:52:00,000
HAS TO BE, ARE WE GOING TO SAVE

3007
01:52:00,000 --> 01:52:03,160
ANY LIVES THIS WAY?

3008
01:52:03,160 --> 01:52:05,400
AND IT'LL BE EASY TO FIND STAGE

3009
01:52:05,400 --> 01:52:06,680
4 CANCER, I MEAN THAT WON'T BE

3010
01:52:06,680 --> 01:52:09,600
ANY KIND OF A STRETCH BUT THOSE

3011
01:52:09,600 --> 01:52:11,760
PEOPLE THAT ARE, YOU KNOW, VERY

3012
01:52:11,760 --> 01:52:13,600
EARLY STAGE AND YOU'RE DETECTING

3013
01:52:13,600 --> 01:52:14,720
A SIGNAL, NOT NECESSARILY

3014
01:52:14,720 --> 01:52:17,960
DETECTING ANYTHING THAT WOULD BE

3015
01:52:17,960 --> 01:52:20,720
CANCER AND SOME OF IT MAY BE

3016
01:52:20,720 --> 01:52:24,200
ABSOLUTELY A  SIGNAL FOR NOTHIN.

3017
01:52:24,200 --> 01:52:27,000
SO IT'S A COMPLEX ISSUE BUT THEY

3018
01:52:27,000 --> 01:52:28,400
HAVE JUST FINISHED ENROLLING IN

3019
01:52:28,400 --> 01:52:31,200
THE UK TRIAL A FEW WEEKS AGO SO

3020
01:52:31,200 --> 01:52:32,320
THAT'S 150,000 PEOPLE I THINK,

3021
01:52:32,320 --> 01:52:35,080
SO, YOU KNOW THEY WILL HAVE--WE

3022
01:52:35,080 --> 01:52:37,120
WILL HAVE A FIRST DATA POINT AND

3023
01:52:37,120 --> 01:52:39,520
WE WILL SEE, YOU KNOW WHAT THAT

3024
01:52:39,520 --> 01:52:41,360
SAYS, BUT I--PEOPLE ARE SELLING

3025
01:52:41,360 --> 01:52:43,560
THIS STUFF ALREADY TO JOHNS

3026
01:52:43,560 --> 01:52:45,040
POINT, THEY'RE SELLING IT AND

3027
01:52:45,040 --> 01:52:48,040
THEY WILL CONTINUE TO SELL IT

3028
01:52:48,040 --> 01:52:50,000
UNDER CLEA BUT I THINK IT'S--I

3029
01:52:50,000 --> 01:52:51,440
THINK IT'S SOMETHING WE REALLY,

3030
01:52:51,440 --> 01:52:52,600
REALLY NEED TO PAY ATTENTION TO

3031
01:52:52,600 --> 01:52:54,200
SO I THANK YOU FOR ALL THAT

3032
01:52:54,200 --> 01:52:58,040
YOU'RE DOING ON THIS.

3033
01:52:58,040 --> 01:52:59,680
>> AND ANN AS IMPORTANT AS
THE

3034
01:52:59,680 --> 01:53:01,840
UK TRIAL IS, IT'S END POINT IS

3035
01:53:01,840 --> 01:53:04,320
NOT A MORTALITY END POINT.

3036
01:53:04,320 --> 01:53:05,120
>> NOT MORTALITY.

3037
01:53:05,120 --> 01:53:05,640
>> SOUND STAGING.

3038
01:53:05,640 --> 01:53:07,400
>> YEAH, AND DOWN STAGING
IS

3039
01:53:07,400 --> 01:53:08,760
IMPORTANT, DON'T GET ME WRONG,

3040
01:53:08,760 --> 01:53:09,360
THAT'S IMPORTANT.

3041
01:53:09,360 --> 01:53:11,880
THAT WILL SAVE LIVES, I THINK.

3042
01:53:11,880 --> 01:53:15,520
BUT DOUG, WHILE I HAVE YOU AND

3043
01:53:15,520 --> 01:53:18,160
WE'RE ANSWERING SOME OF OUR

3044
01:53:18,160 --> 01:53:19,240
QUESTIONS, I KNOW WE HAVE

3045
01:53:19,240 --> 01:53:20,920
ANNOUNCED THAT WE HAVE A--WE

3046
01:53:20,920 --> 01:53:22,360
HAVE A CANDIDATE DIRECTOR FOR

3047
01:53:22,360 --> 01:53:29,040
NCI, CAN YOU SAY SOMETHING ABOUT

3048
01:53:29,040 --> 01:53:29,480
THE PROCESS.

3049
01:53:29,480 --> 01:53:30,640
>> SURE AND I'M GOING TO
SAY

3050
01:53:30,640 --> 01:53:32,280
SOMETHING IN MY REMARKS.

3051
01:53:32,280 --> 01:53:36,040
SO CAN YOU SOMETHING TO US, TOO.

3052
01:53:36,040 --> 01:53:42,560
>> THE WHITE HOUSE NAMED
MONICA

3053
01:53:42,560 --> 01:53:43,080
BERTENOLLI, OUTSTANDING

3054
01:53:43,080 --> 01:53:46,360
PHYSICIAN SCIENTIST IN BOSTON.

3055
01:53:46,360 --> 01:53:49,760
AND WE'RE LOOKING FORWARD TO HER

3056
01:53:49,760 --> 01:53:52,240
COMING AS SOON AS SHE CAN BE

3057
01:53:52,240 --> 01:53:55,520
VETTED AND APPOINTED.

3058
01:53:55,520 --> 01:53:57,520
>> WELL, WE ALL KNOW
MONICA AND

3059
01:53:57,520 --> 01:54:00,000
YOU'RE RIGHT, SHE WILL BE--SHE'S

3060
01:54:00,000 --> 01:54:00,520
A FINE CHOICE.

3061
01:54:00,520 --> 01:54:02,760
BUT I WANTED TO JUST ON BEHALF

3062
01:54:02,760 --> 01:54:04,760
OF MYSELF AND THE COMMITTEE, AND

3063
01:54:04,760 --> 01:54:07,800
I'M PRETTY SURE THE WHOLE NCAB,

3064
01:54:07,800 --> 01:54:11,040
YOU ARE SUCH A DEDICATED,

3065
01:54:11,040 --> 01:54:12,480
WONDERFUL PUBLIC SERVICE ANT, IF

3066
01:54:12,480 --> 01:54:14,680
I PUT UP A BOX THAT SAID PUBLIC

3067
01:54:14,680 --> 01:54:15,920
SERVANT, IT WOULD HAVE YOUR

3068
01:54:15,920 --> 01:54:18,320
PICTURE ON IT SO ANYWAY, WE LOVE

3069
01:54:18,320 --> 01:54:19,520
YOU AND WE REALLY THINK YOU'VE

3070
01:54:19,520 --> 01:54:21,200
DONE A INGREDIENT JOB FOR US.

3071
01:54:21,200 --> 01:54:22,640
SO THANK YOU.

3072
01:54:22,640 --> 01:54:29,280
>> YOU KNOW, THE NCI IS
FAR TOO

3073
01:54:29,280 --> 01:54:32,000
IMPORTANT NOT TO MAKE CRITICAL

3074
01:54:32,000 --> 01:54:36,200
DECISIONS AS WE GO, AS WE GO

3075
01:54:36,200 --> 01:54:36,680
ALONG.

3076
01:54:36,680 --> 01:54:47,240
AND AS I SAID LAST TIME IN JUNE,

3077
01:54:56,360 --> 01:54:57,920
THAT I MADE THE JOKE THAT WE

3078
01:54:57,920 --> 01:55:01,520
NEED TO CHANGE THE NAME IN NCI

3079
01:55:01,520 --> 01:55:01,760
TO NCB,.

3080
01:55:01,760 --> 01:55:03,400
>> THAT'S FUNNY, BUT ON
BEHALF

3081
01:55:03,400 --> 01:55:04,600
OF THE SUBCOMMITTEE YOU ANSWER

3082
01:55:04,600 --> 01:55:06,400
OUR QUESTIONS AND HAVE BEEN VERY

3083
01:55:06,400 --> 01:55:07,960
KIND TO ALWAYS KEEP US INFORMED

3084
01:55:07,960 --> 01:55:08,920
SO WE REALLY DO APPRECIATE IT

3085
01:55:08,920 --> 01:55:11,040
AND WE WILL LOOK FORWARD TO IT.

3086
01:55:11,040 --> 01:55:13,040
>> THANKS FOR ALL OF YOUR

3087
01:55:13,040 --> 01:55:14,680
INTEREST AND COMMITMENT, YOU

3088
01:55:14,680 --> 01:55:21,280
KNOW, YOU AND EVERYBODY ELSE ON

3089
01:55:21,280 --> 01:55:23,960
THE BOARD AND YOU KNOW I'VE BEEN

3090
01:55:23,960 --> 01:55:26,800
TALKING OFFLINE WITH JOHN ABOUT

3091
01:55:26,800 --> 01:55:31,440
YOU KNOW HOW YOU MIGHT BE ABLE

3092
01:55:31,440 --> 01:55:34,360
TO HAVE EVEN MORE AN IMPACT, YOU

3093
01:55:34,360 --> 01:55:36,520
KNOW NOT LOBBYING CONGRESS BUT

3094
01:55:36,520 --> 01:55:41,960
INSTEAD, YOU KNOW, HELPING US TO

3095
01:55:41,960 --> 01:55:43,720
DO AN EENCH BETTER JOB.

3096
01:55:43,720 --> 01:55:45,360
>> YEAH AND I TALKED TO
JOHN

3097
01:55:45,360 --> 01:55:47,120
ABOUT THIS, AS PAULET KNOWS THIS

3098
01:55:47,120 --> 01:55:49,000
IS A COMMITTEE THAT COULD BE A

3099
01:55:49,000 --> 01:55:50,520
LOT MORE FUNCTIONAL, A LOT MORE

3100
01:55:50,520 --> 01:55:53,320
TO HELP THE NCI, WE CANNOT LOBBY

3101
01:55:53,320 --> 01:55:54,720
CONGRESS, IF YOU RAISE YOUR

3102
01:55:54,720 --> 01:55:56,560
CONFLICT OF INTEREST STATEMENTS,

3103
01:55:56,560 --> 01:55:58,200
YOU KNOW THAT'S NOT GOOD, YOU

3104
01:55:58,200 --> 01:56:00,320
CAN DO THINGS PERSONALLY, NCI

3105
01:56:00,320 --> 01:56:01,840
DOESN'T CONTROL THAT, BUT MANY

3106
01:56:01,840 --> 01:56:04,280
OF US DO, BUT, I THINK JOHN,

3107
01:56:04,280 --> 01:56:06,800
THAT'S SOMETHING HA IS REALLY A

3108
01:56:06,800 --> 01:56:07,520
DISCUSSION WE SHOULD HAVE

3109
01:56:07,520 --> 01:56:09,960
BECAUSE THERE ARE THINGS THAT WE

3110
01:56:09,960 --> 01:56:12,120
COULD DO TO HELP NOT JUST

3111
01:56:12,120 --> 01:56:13,000
THROUGH THIS SUBCOMMITTEE BUT

3112
01:56:13,000 --> 01:56:16,440
THE WHOLE OF THE NCAB.

3113
01:56:16,440 --> 01:56:19,160
>> YEAH, I SORT OF THINK
OF THE

3114
01:56:19,160 --> 01:56:19,800
WORD REIMAGINE AND.

3115
01:56:19,800 --> 01:56:23,000
>> I HATE THAT WORD BUT
OKAY.

3116
01:56:23,000 --> 01:56:28,800
>> BUT IT--AS WE THINK
ABOUT THE

3117
01:56:28,800 --> 01:56:29,120
NCI-

3118
01:56:29,120 --> 01:56:29,520
>> JOHN.

3119
01:56:29,520 --> 01:56:31,600
>> WE'RE IN AN OPEN
SESSION,

3120
01:56:31,600 --> 01:56:32,800
JUST WANT TO REMIND YOU SO CAN

3121
01:56:32,800 --> 01:56:35,480
YOU CHOOSE YOUR WORDS CAREFULLY.

3122
01:56:35,480 --> 01:56:35,920
>> OKAY.

3123
01:56:35,920 --> 01:56:37,240
>> YES, YES AND DON'T
REIMAGINE

3124
01:56:37,240 --> 01:56:41,440
IT, THAT WORD IS SO OVERUSED

3125
01:56:41,440 --> 01:56:41,720
RIGHT NOW.

3126
01:56:41,720 --> 01:56:42,560
>> WELL I REMEMBER THE
SAME

3127
01:56:42,560 --> 01:56:45,680
THING WHEN WE USED TO USE THE

3128
01:56:45,680 --> 01:56:47,240
WORD TRANSLATION.

3129
01:56:47,240 --> 01:56:49,440
>> THAT'S TRUE.

3130
01:56:49,440 --> 01:56:49,920
>> TRANSFORMATIONAL.

3131
01:56:49,920 --> 01:56:50,600
>> YEAH, TRANSFORMATION,
THAT'S

3132
01:56:50,600 --> 01:56:51,440
THE OTHER WORD.

3133
01:56:51,440 --> 01:56:53,480
OKAY, I'M PART OF AN INSTITUTE

3134
01:56:53,480 --> 01:56:56,040
THAT HAS THAT IN ITS TITLE.

3135
01:56:56,040 --> 01:56:58,080
>> BUT I WANT TO ECHO
ANN'S

3136
01:56:58,080 --> 01:57:01,280
COMMENTS ABOUT THE NCI AND THE

3137
01:57:01,280 --> 01:57:02,960
LEADERSHIP AND YOU KNOW IT'S AN

3138
01:57:02,960 --> 01:57:04,800
INTUITION, IT'S NOT A PERSON.

3139
01:57:04,800 --> 01:57:08,680
BUT YOU KNOW, DOUG, DINA AND THE

3140
01:57:08,680 --> 01:57:10,640
ENTIRE NCI IT'S BEEN FANTASTIC

3141
01:57:10,640 --> 01:57:12,720
AND WE REALLY LOOK FORWARD TO

3142
01:57:12,720 --> 01:57:15,520
SEEING EVEN MORE IMPACT GOING

3143
01:57:15,520 --> 01:57:15,760
FORWARD.

3144
01:57:15,760 --> 01:57:16,960
>> HERE HERE.

3145
01:57:16,960 --> 01:57:18,240
>> WELL, LISTEN, WE ARE
JUST

3146
01:57:18,240 --> 01:57:20,000
ABOUT A MINUTE AHEAD SO I WILL

3147
01:57:20,000 --> 01:57:22,320
GIVE THAT BACK TO YOU ALL AND WE

3148
01:57:22,320 --> 01:57:23,840
WILL SEE YOU ON THE OTHER SIDE

3149
01:57:23,840 --> 00:00:00,000
IN ABOUT 5 MINUTES