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CALL THE MEETING TO ORDER.  I 

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WOULD LIKE TO WELCOME MEMBERS OF

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THE ADVISORY BOARD.  EX OFFICIO 

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MEMBER AND STAFF AND GUESTS.  

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MEMBERS OF THE PUBLIC, WHO MAY 

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WISH TO EXPRESS THEIR VIEWS 

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REGARDING ANY ITEMS DISCUSSED 

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DURING THIS MEETING MAY DO SO BY

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WRITING TO THE DOCTOR WITHIN TEN

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DAYS FOLLOWING THE MEETING.  ANY

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WRITTEN STATEMENTS OR QUESTIONS 

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SUBMITTED BY MEMBERS OF THE 

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PUBLIC WILL RECEIVE CAREFUL 

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CONSIDERATION.  AS BOARD 

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MEMBERS, I WANT TO REMIND YOU 

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THAT YOU MUST ABSENT YOURSELVES 

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DURING SPECIFIC DISCUSSIONS 

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WHENEVER YOUR PARTICIPATION, 

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DELIBERATIONS ON A PARTICULAR 

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PRODUCT, PROGRAM OR OTHER 

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SPECIFIC MATTER WOULD CONSTITUTE

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A CONFLICT OF INTEREST OR CREATE

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THE APPEARANCE OF ONE.  IT IS 

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INCUMBENT UPON OURSELVES TO 

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ADVISE THE EXECUTIVE SECRETARY 

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AND ABSTAIN FROM ANY DISCUSSIONS

27
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REGARDING THESE MATTERS: 

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CONSIDERING THE CURRENT POLICIES

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GOVERNING CONFLICT OF INTEREST 

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BASED ON FINANCIAL HOLDINGS OF 

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SPECIAL GOVERNMENT EMPLOYEES 

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WHICH WE ALL ARE AS BOARD 

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MEMBERS, WE MUST DEPEND UPON 

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OURSELVES TO VOLLEY ABSENT 

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OURSELVES DURING ANY AND ALL 

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DISCUSSIONS OF MATTERS THAT 

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COULD CONCEIVABLY IMPACT THE 

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STATUS OF THESE HOLDINGS WE 

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TRUST YOUR JUDGMENT IN THESE 

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INSTANCE DURING ANY CLOSED 

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SESSION, ANY MATERIALS OR 

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DISCUSSIONS OF CONFIDENTIAL 

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NATURE DELIBERATED ON TODAY ARE 

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PRIVILEGED INFORMATION AND ARE 

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MADE AVAILABLE TO YOU ON A NEED 

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TO KNOW BASIS SUCH DELIBERATIONS

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ARE PRIVATE AND THEIR CONTENT 

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AND NOT BE DIVULGED.  QUORUM, 

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REQUIRED FOR EACH INSTANCE IN 

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WHICH A VOTE MAY OCCUR WHETHER 

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IN OPEN OR CLOSED SESSION DURING

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THIS MEETING A MINIMUM OF TEN 

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APPOINTED MEMBERS MUST BE 

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PRESENT TO VOICE THEIR VOTES 

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SINCE WE CAN'T PREDICT THE TIME 

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OR OCCURRENCE OF ANY MOTION YOUR

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PRESENCE IN THE ROOM AND IN THE 

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HYBRID ROOM FOR ALL SEGMENTS OF 

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THE MEETING IS A MUST.  DO WE 

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HAVE QUORUM?  FUTURE MEETINGS 

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ARE LISTED ON THE AGENDA AND 

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LISTED ON CANCER.GOV WE NEED TO 

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APPROVE THE JUNE THROUGH 

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NOVEMBER HYBRID MEETING SUMMARY.

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IS THERE A MOTION TO APPROVE?  

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SECOND?  ANY FURTHER DISCUSSION?

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SO LET'S VOTE.  ARE THERE ANY 

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MAYS?  ANY ABSTENTIONS?  IT'S 

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UNANIMOUS.  ALSO PHONES OR OTHER

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DEVISES SHOULD BE TURNED OFF OR 

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SET TO VIBRATE.  WHENEVER THESE 

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INSTRUMENTS GO OFF THEY CAN 

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DISRUPT THE MEETING.  THIS APPLY

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TO STAFF MEMBERS AND OTHERS IN 

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THE ROOM.  AGAIN, TO ENSURE NO 

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INTERRUPTIONS DURING TODAY'S 

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MEETING MEMBERS PARTICULARLY 

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VIRTUALLY SHOULD PUT  MUTE 

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YOURSE

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YOURSELVES.  SO WE'LL NOW START 

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TODAY'S AGENDA WITH THE NCI 

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DIRECTOR'S REPORT.  

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DR. RATHMELL.

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>> DR. RATHMELL: GOOD
MORNING, 

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WE HAVE THE SLIDES TOO?  IT'S A 

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PLEASURE TO BE UP HERE WITH YOU 

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AND TELL YOU ABOUT WHAT'S BEEN A

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REALLY BUSY SUMMER SINCE WE WERE

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TOGETHER LAST IN JUNE.  LET ME 

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JUST MOVE AHEAD.  MAYBE, I'M 

91
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HAVING SOME CHALLENGES.  SO MANY

92
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THINGS TO PUSH SO TODAY WE'LL DO

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SOME UPDATES SINCE THE LAST JUNE

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MEETING.  I AM GOING TO TALK A 

95
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LITTLE BIT ABOUT BUDGET BUT IN 

96
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THE FORMAT OF THE PROFESSIONAL 

97
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JUDGMENT BUDGET PROPOSAL THE 

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HEAVY LIFTING WILL BE RIGHT 

99
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AFTER ME BY DR. LOW WE AND 

100
00:04:30,437 --> 00:04:32,907
WESTON RICKS.  WE WILL TALK 

101
00:04:32,907 --> 00:04:35,042
ABOUT OUR RESEARCH HIGHLIGHT AND

102
00:04:35,042 --> 00:04:38,579
I WILL SET TIME AVAILABLE FOR 

103
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QUESTIONS.  SO DIVING JUMP RIGHT

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IN.  IT HAS BEEN A REALLY BUSY 

105
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SUMMER. 

106
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TO GIVE YOU AN EXAMPLE OF SOME 

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OF THE THINGS THAT WE'VE BEEN 

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DOING, FIRST, ONE OF MY 

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INTENTIONAL ACTIVITIES HAS BEEN 

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SPENDING SOME TIME GETTING TO 

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KNOW OUR N CORP PROGRAMS.  

112
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YOU'LL HEAR MORE ABOUT THAT 

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LATER TODAY FROM PHIL CASTLE AND

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JIM D.  THE FIRST VISITS THAT I 

115
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WENT TO WERE TO KANSAS. 

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A FEDERATED SYSTEM GIVING ME 

117
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GREAT INSIGHTS INTO HOW YOU 

118
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DELIVER CARE ACROSS A REALLY 

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VAST REGION OF THE MIDWEST.  

120
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SOME REALLY INNOVATIVE WORK 

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THAT'S HAMMING THERE.  I ALSO 

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VISITED THE BRONX. 

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TO NCORP SITES THERE.  VERY 

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DIFFERENT OF COURSE.  A SMALLER 

125
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GEOGRAPHY BUT 27 DIFFERENT 

126
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LANGUAGES COMMONLY SPOKEN BY 

127
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THEIR PATIENTS.  32% IMMIGRANT 

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POPULATION.  30% POVERTY AND IN 

129
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THAT SETTING, THEY HAVE HAD 

130
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RECORD CLINICAL TRIAL 

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ENROLLMENT.  THEY WERE FIRST 

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OPENING THE CLINICAL TRIALS 

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OFFICE WHICH WE HIGHLIGHTED AT 

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ONE OF THE LAST SESSIONS AND 

135
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HAVE REALLY FOCUSED ON 

136
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STREAMLINING OPENING OF THEIR 

137
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CLINICAL TRIALS SO REALLY A LOT 

138
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WE CAN LEARN FROM THESE SITES 

139
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AND THIS IS WHERE OUR PATIENTS 

140
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RECEIVE THEIR CARE AND THIS IS A

141
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PART OF OUR TALENT POOL IS OUR 

142
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COMMUNITY ONCOLOGY BASE.  I ALSO

143
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SPENT SOME TIME GOING OUT TO 

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PROGRAMS THAT SUPPORT TRAINING. 

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SO THE M.D.-PH.D. PROGRAM DOES A

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NATIONAL MEETING AND WAS 

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PRIVILEGED TO BE ONE OF THEIR 

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KEYNOTES THAT WAS HELD IN 

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COLORADO. 

150
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THE PICTURE THERE SI THINK FROM 

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SOME STUDENTS FROM INDIANA 

152
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UNIVERSITY. 

153
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SO INCREDIBLE ENERGY AMONG OUR 

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FUTURE PHYSICIAN SCIENTISTS AND 

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IT WAS A REAL HONOR THERE TO 

156
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TALK ABOUT WHY CANCER RESEARCH 

157
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IS THE FIELD THEY SHOULD SPEND 

158
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THEIR TIME DEVELOPING.  I ALSO 

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GOT TO VISIT THE UNIVERSITY OF 

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CHICAGO.  THIS WAS THEIR 50TH 

161
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ANNIVERSARY OF THEIR CANCER 

162
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CENTER BUT THEY USED THAT 50TH 

163
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ANNIVERSARY AND SPENT THE 

164
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CELEBRATION ON A SYMPOSIUM FOR 

165
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THEIR STUDENTS, AN ANNUAL 

166
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SYMPOSIUM EVENT THAT THEY DO 

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WHICH HIGHLIGHTED EVERYTHING.  

168
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THEY ROW CENTLY REYOUED THEIR 

169
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PROGRAM. 

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YOU WILL HEAR MORE ABOUT THAT 

171
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FROM DR. SONYA SPRING FIELD.  

172
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THAT AND OTHER PROGRAMS BUT 

173
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THEY'RE ALSO PILOTING REALLY 

174
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EXCITING THINGS THAT I FOUND 

175
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USEFUL TO BE REALLY THINKING 

176
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ABOUT.  LIKE, PILOTING PROGRAMS 

177
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THAT PARTNER WITH COMMUNITY 

178
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COLLEGES IN THE AREA, THE 

179
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MALCOLM X COMMUNITY COLLEGE IS 

180
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ONE EXAMPLE WHERE THEY'RE 

181
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LOOKING AT TAKING ASSOCIATE'S 

182
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DEGREE STUDENTS AND EQUIPPING 

183
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THEM WITH THE SKILLS TO BE PART 

184
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OF THE CLINICAL TRIALS OFFICE. 

185
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REALLY MEETING A NEED ON 

186
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MULTIPLE AREAS.  AND THEN 

187
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BUILDING OUR RELATIONSHIPS 

188
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GLOBALLY.  THE WHO HAD A VISIT 

189
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HERE.  THEY HAVE A COLLABORATING

190
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CENTER FOR GLOBAL HEALTH -- 

191
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GLOBAL CANCER RESEARCH AND WE'RE

192
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HERE SPENDING A DAY WORKSHOPPING

193
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AROUND A LOT OF WORK IN THAT 

194
00:07:44,798 --> 00:07:46,800
AREA BUT I ALSO WANT TO 

195
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HIGHLIGHT A COUPLE OF SPECIFIC 

196
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FOCUS AREAS.  AUSTRALIA IS ONE 

197
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EXAMPLE.  WE HOSTED THE 

198
00:07:52,873 --> 00:07:55,175
AMBASSADOR TO AUSTRALIA, 

199
00:07:55,175 --> 00:07:56,043
CAROLINE KENNEDY AND TALKED 

200
00:07:56,043 --> 00:07:59,413
ABOUT WHAT THE EFFORTS ARE 

201
00:07:59,413 --> 00:08:02,182
AROUND HPV VACCINATION AND 

202
00:08:02,182 --> 00:08:04,385
CERVICAL CANCER.  WE MET WITH A 

203
00:08:04,385 --> 00:08:06,387
GROUP OF SENATORS FROM 

204
00:08:06,387 --> 00:08:07,454
AUSTRALIA.  I COULDN'T JOIN YOU 

205
00:08:07,454 --> 00:08:10,691
LAST NIGHT FOR THE SUBCOMMITTEES

206
00:08:10,691 --> 00:08:12,893
BECAUSE I WAS WITH THE 

207
00:08:12,893 --> 00:08:15,162
AMBASSADOR TO AUSTRALIA TALKING 

208
00:08:15,162 --> 00:08:16,330
ABOUT WHERE LARGER SCALE 

209
00:08:16,330 --> 00:08:17,831
COLLABORATIONS CAN HAPPEN ACROSS

210
00:08:17,831 --> 00:08:20,567
OUR SCIENTIFIC INTERESTS.  WE 

211
00:08:20,567 --> 00:08:22,336
ALSO HAD TIME TO SPEND WITH OUR 

212
00:08:22,336 --> 00:08:23,637
COLLEAGUES FROM JAPAN.  THIS IS 

213
00:08:23,637 --> 00:08:26,173
THE COALITION OF THE NATIONAL 

214
00:08:26,173 --> 00:08:28,876
CANCER CENTER IN JAPAN.  LATER 

215
00:08:28,876 --> 00:08:33,180
NEXT WEEK THERE'LL BE A 

216
00:08:33,180 --> 00:08:33,914
SYMPOS

217
00:08:33,914 --> 00:08:34,515
SYMPOS

218
00:08:34,515 --> 00:08:36,683
SYMPOSIUM ON THIS WHICH WE'LL BE

219
00:08:36,683 --> 00:08:38,185
SPEAKING AT AGAIN TALKING ABOUT 

220
00:08:38,185 --> 00:08:40,287
SOME OF OUR COLLABORATIONS.  I 

221
00:08:40,287 --> 00:08:43,257
DON'T HAVE A PICTURE HERE FROM 

222
00:08:43,257 --> 00:08:44,892
THE FIRST U.S. INDIA DIALOGUE 

223
00:08:44,892 --> 00:08:48,862
WHICH WAS ATTENDED IN-PERSON BY 

224
00:08:48,862 --> 00:08:50,898
THE DOCTOR.  I ATTENDED 

225
00:08:50,898 --> 00:08:52,199
VIRTUALLY.  LOOKING FOR OUR 

226
00:08:52,199 --> 00:08:53,834
COUNTRIES TO COLLABORATE WITH A 

227
00:08:53,834 --> 00:08:55,936
LOT OF EMPHASIS ON IMMUNOLOGY 

228
00:08:55,936 --> 00:08:58,472
BUT OTHER AREAS LIKE AI AND 

229
00:08:58,472 --> 00:09:00,874
TECHNOLOGY AS WELL.  I PICKED 

230
00:09:00,874 --> 00:09:03,644
THESE ONES BECAUSE U.S., 

231
00:09:03,644 --> 00:09:06,246
AUSTRALIA JAPAN AND INDIA FORM 

232
00:09:06,246 --> 00:09:06,980
WHAT'S CALLED THE QUAD AND THIS 

233
00:09:06,980 --> 00:09:08,248
IS BIGGER THAN CANCER. 

234
00:09:08,248 --> 00:09:10,284
THIS IS A GROUP OF COUNTRIES 

235
00:09:10,284 --> 00:09:11,985
THAT ARE WORKING TOGETHER WITH A

236
00:09:11,985 --> 00:09:13,587
COMMITTED INITIATIVE TO TACKLE 

237
00:09:13,587 --> 00:09:15,856
THE WORLD'S MOST COMPLICATED 

238
00:09:15,856 --> 00:09:17,724
PROBLEMS.  AND SO I WOULD ARGUE 

239
00:09:17,724 --> 00:09:21,829
THAT CANCER FITS THAT VERY WELL 

240
00:09:21,829 --> 00:09:23,230
AND SO BUILDING THOSE 

241
00:09:23,230 --> 00:09:24,198
RELATIONSHIPS IS A PART OF HOW 

242
00:09:24,198 --> 00:09:27,634
WE INVEST IN A LOT OF OUR 

243
00:09:27,634 --> 00:09:30,804
FUTURE.  WE ALSO SPENT SOME TIME

244
00:09:30,804 --> 00:09:31,405
WORKING WITH THE WHITE HOUSE 

245
00:09:31,405 --> 00:09:33,474
WHICH WAS STILL BUSY IN THE 

246
00:09:33,474 --> 00:09:35,742
CANCER ARENA THIS SUMMER.  HERE,

247
00:09:35,742 --> 00:09:37,778
I GOT THE OPPORTUNITY TO TALK TO

248
00:09:37,778 --> 00:09:40,514
THE OFFICE OF MANAGEMENT AND 

249
00:09:40,514 --> 00:09:41,315
BUDGET.  THE EXAMINERS CAME TO 

250
00:09:41,315 --> 00:09:43,350
THE NIH AND REALLY WANTED TO 

251
00:09:43,350 --> 00:09:44,585
HEAR ABOUT WHAT WE'RE DOING IN 

252
00:09:44,585 --> 00:09:45,986
CANCER.  WHAT WERE THE OUTCOMES 

253
00:09:45,986 --> 00:09:47,721
OF THE MOON SHOT?  HOW IS IT 

254
00:09:47,721 --> 00:09:50,991
THAT THE INVESTMENTS ARE SPENT 

255
00:09:50,991 --> 00:09:51,692
WISELY?  THEY WERE SO INTERESTED

256
00:09:51,692 --> 00:09:54,094
IN WHAT WE WERE DOING IN THE 

257
00:09:54,094 --> 00:09:56,463
FREDERICK NATIONAL LABS THAT WE 

258
00:09:56,463 --> 00:09:57,664
BROUGHT THEM BACK AND DID A TOUR

259
00:09:57,664 --> 00:09:59,900
OF THE LABS.  AND REALLY GOT TO 

260
00:09:59,900 --> 00:10:01,702
SHOW THEM WHAT THE CAPABILITIES 

261
00:10:01,702 --> 00:10:03,737
ARE OF THE CANCER INSTITUTE. 

262
00:10:03,737 --> 00:10:05,372
AND WHERE WE CAN MAKE A REAL 

263
00:10:05,372 --> 00:10:07,975
DIFFERENCE.  WE ALSO HAVE BEEN 

264
00:10:07,975 --> 00:10:09,676
WORKING HHS WITH THE DEPUTY 

265
00:10:09,676 --> 00:10:12,846
SECRETARY WITH MEETINGS.  THAT, 

266
00:10:12,846 --> 00:10:14,948
AGAIN, ALSO PIQUED THEIR 

267
00:10:14,948 --> 00:10:15,782
INTEREST IN WHAT IT IS THAT WE 

268
00:10:15,782 --> 00:10:17,918
HAVE CAPABILITIES OF AND BROUGHT

269
00:10:17,918 --> 00:10:20,320
HER HERE TO CAMPUS TO DO A 

270
00:10:20,320 --> 00:10:21,588
VIRTUAL VISIT FOR THE FREDERICK 

271
00:10:21,588 --> 00:10:24,191
NATIONAL LABS AND ALSO TO TALK 

272
00:10:24,191 --> 00:10:25,526
ABOUT WORLDWIDE EFFORTS THAT WE 

273
00:10:25,526 --> 00:10:27,661
CAN MAKE A BIG DIFFERENCE, 

274
00:10:27,661 --> 00:10:30,964
AGAIN, FOCUSING ON HPV.  IN 

275
00:10:30,964 --> 00:10:32,332
JUNE, I TOLD YOU THAT WE WERE 

276
00:10:32,332 --> 00:10:33,734
HAVING A RETREAT SO ONE OF THE 

277
00:10:33,734 --> 00:10:35,469
HIGHLIGHTS OF THE SUMMER WAS A 

278
00:10:35,469 --> 00:10:37,804
RETREAT THAT WE HELD THE FIRST 

279
00:10:37,804 --> 00:10:39,740
OF ITS KIND WHICH WAS OUR 

280
00:10:39,740 --> 00:10:42,075
LEADERSHIP PLUS THE BOARD 

281
00:10:42,075 --> 00:10:43,176
LEADERS SO DR. CARP TEN JOINED 

282
00:10:43,176 --> 00:10:45,746
US AND THE GOAL OF THIS RETREAT 

283
00:10:45,746 --> 00:10:48,882
WAS TO SURVEY THE LANDSCAPE OF 

284
00:10:48,882 --> 00:10:51,585
CANCER INITIATIVES TO DECIDE 

285
00:10:51,585 --> 00:10:52,986
WHERE WE CAN PUT BIG FOCUS AREAS

286
00:10:52,986 --> 00:10:55,188
THAT CAN MAKE A REAL DIFFERENCE.

287
00:10:55,188 --> 00:10:58,525
NOT A SMALL TOPIC TO TAKE ON.  

288
00:10:58,525 --> 00:11:00,894
BUT OVER THE COURSE OF THE DAY 

289
00:11:00,894 --> 00:11:03,797
WRESTLED WITH A LOT OF DIFFERENT

290
00:11:03,797 --> 00:11:04,898
REAL ISSUES.  PARTICULARLY 

291
00:11:04,898 --> 00:11:06,700
SPENDING A LOT OF TIME AROUND 

292
00:11:06,700 --> 00:11:08,602
WHATEVER WE DO, HAS TO BUILD 

293
00:11:08,602 --> 00:11:12,806
TRUST.  HAS TO DEMONSTRATE OUR 

294
00:11:12,806 --> 00:11:15,375
TRUSTWORTHINESS AND DEMONSTRATE 

295
00:11:15,375 --> 00:11:16,610
OUR COMMUNITIES AND A 

296
00:11:16,610 --> 00:11:18,011
COMMUNICATION EFFORT ALONG WITH 

297
00:11:18,011 --> 00:11:20,480
GOOD SCIENCE SO WE TALKED ABOUT 

298
00:11:20,480 --> 00:11:22,983
A LOT OF DIFFERENT INITIATIVES, 

299
00:11:22,983 --> 00:11:25,452
THE TANGIBLE OUTPUTS.  I WILL BE

300
00:11:25,452 --> 00:11:28,589
ANNOUNCING A LITTLE BIT LATER 

301
00:11:28,589 --> 00:11:33,760
HOPEFULLY IN THE FALL SO LOOK 

302
00:11:33,760 --> 00:11:35,462
FORWARD FROM MORE TO COME ON 

303
00:11:35,462 --> 00:11:36,897
THIS BUT THIS WAS A GREAT 

304
00:11:36,897 --> 00:11:38,165
OPPORTUNITY TO BUILD IDEAS AND 

305
00:11:38,165 --> 00:11:39,299
BUILD MOMENTUM AROUND IMPORTANT 

306
00:11:39,299 --> 00:11:44,271
AREAS FOR CANCER RESEARCH.  

307
00:11:44,271 --> 00:11:46,707
OKAY.  I ALSO LAST JUNE TOLD YOU

308
00:11:46,707 --> 00:11:48,742
THAT WE HAD COME TO SOME 

309
00:11:48,742 --> 00:11:50,611
DECISIONS ABOUT SOME NEW 

310
00:11:50,611 --> 00:11:51,244
LEADERSHIP POSITIONS.  BUT I 

311
00:11:51,244 --> 00:11:54,014
COULDN'T TELL YOU WHO THEY WERE.

312
00:11:54,014 --> 00:11:55,949
SO -- BUT KNEW WE CAN.  THEY 

313
00:11:55,949 --> 00:11:57,718
WERE SWORN IN LAST WEEK.  SO 

314
00:11:57,718 --> 00:12:00,721
FIRST I WILL TELL YOU THAT PETER

315
00:12:00,721 --> 00:12:01,655
GARRET, IF YOU WANT TO LET 

316
00:12:01,655 --> 00:12:07,694
EVERYONE KNOW WHO YOU ARE.  SO 

317
00:12:07,694 --> 00:12:10,664
PETER GARRET, BEFORE I TELL YOU 

318
00:12:10,664 --> 00:12:12,366
ABOUT PETER.  BOTH OF THESE 

319
00:12:12,366 --> 00:12:13,033
INDIVIDUALS WERE BROUGHT THROUGH

320
00:12:13,033 --> 00:12:16,870
IN THE POSITIONS THROUGH 

321
00:12:16,870 --> 00:12:21,808
NATIONAL SEARCHES.  BOTH WERE 

322
00:12:21,808 --> 00:12:26,213
INTERNAL HIRES.  PETER HAS BEEN 

323
00:12:26,213 --> 00:12:28,448
LEADING THE OFFICE OF PUBLIC 

324
00:12:28,448 --> 00:12:29,516
LIAISON WHICH NOW WILL BE 

325
00:12:29,516 --> 00:12:30,951
WORKING VERY CLOSELY WITH, I 

326
00:12:30,951 --> 00:12:32,619
ALWAYS FORGET THE NAMES OF ALL 

327
00:12:32,619 --> 00:12:36,323
MY OFFICES THE OFFICE OF 

328
00:12:36,323 --> 00:12:36,923
GOVERNMENT AND CONGRESSIONAL 

329
00:12:36,923 --> 00:12:39,793
RELATIONS.  MK WHO YOU WILL HEAR

330
00:12:39,793 --> 00:12:43,830
FROM LATER.  AND ALSO THE OFFICE

331
00:12:43,830 --> 00:12:51,838
OF ADVOCACY RELATIONS.  WHICH IS

332
00:12:51,838 --> 00:12:54,441
AMY WILLIAMS.  THAT GROUP WILL 

333
00:12:54,441 --> 00:12:56,009
BE WORKING CLOSELY TOGETHER.  

334
00:12:56,009 --> 00:12:56,677
THIS WILL BE TACKLING WHAT WE 

335
00:12:56,677 --> 00:12:58,679
TALKED ABOUT IN THE RETREAT.  

336
00:12:58,679 --> 00:13:00,881
HOW DO WE COMMUNICATE MOST 

337
00:13:00,881 --> 00:13:01,515
EFFECTIVELY ACROSS THIS BROAD 

338
00:13:01,515 --> 00:13:03,817
AREA AND BRING ALL OF THESE 

339
00:13:03,817 --> 00:13:05,852
RESOURCES MOVING VERY MUCH 

340
00:13:05,852 --> 00:13:09,289
FORWARD AND THEN AMBER LOWER RI.

341
00:13:09,289 --> 00:13:13,460
AMBER HAS BEEN THE ACTING DEPUTY

342
00:13:13,460 --> 00:13:15,028
DIRECTOR FOR MANAGEMENT.  AND 

343
00:13:15,028 --> 00:13:17,864
REALLY THE KEYS TO HOW THE WHOLE

344
00:13:17,864 --> 00:13:20,067
THING WORKS.  WE'RE HAPPY TO 

345
00:13:20,067 --> 00:13:21,401
TAKE ACTING AWAY AND SHE WILL 

346
00:13:21,401 --> 00:13:23,904
TAKE US ON INTO THE FUTURE.  I 

347
00:13:23,904 --> 00:13:27,841
ALSO MENTIONED IN JUNE A NEW 

348
00:13:27,841 --> 00:13:31,912
DEPUTY FOR DATA SCIENCE AND 

349
00:13:31,912 --> 00:13:34,181
STRATEGY.  DR. K. WHERE ARE YOU?

350
00:13:34,181 --> 00:13:37,417
NOT OFFICIAL YET.  BUT NOW HE'S 

351
00:13:37,417 --> 00:13:38,985
OFFICIAL.  AND HAS BEEN HIT -- 

352
00:13:38,985 --> 00:13:41,488
HAS REALLY HIT THE GROUND 

353
00:13:41,488 --> 00:13:44,257
RUNNING, HAS BEEN LEARNING A LOT

354
00:13:44,257 --> 00:13:45,459
ABOUT WHAT WE'RE DOING AND 

355
00:13:45,459 --> 00:13:47,160
HELPING US BE BETTER IN THE 

356
00:13:47,160 --> 00:13:50,097
AREAS OF DATA SCIENCE, AI, 

357
00:13:50,097 --> 00:13:51,031
YOU'RE GOING TO HEAR FROM HIM 

358
00:13:51,031 --> 00:13:52,399
AND A TEAM A LITTLE BIT LATER 

359
00:13:52,399 --> 00:13:55,402
TODAY.  SO I'M REALLY EXCITED 

360
00:13:55,402 --> 00:13:58,405
ABOUT THAT SO THAT IS AT 1:10 

361
00:13:58,405 --> 00:14:00,173
TODAY.  I ALSO WANT TO PUT OUT A

362
00:14:00,173 --> 00:14:10,350
PLUG FOR A BIG PART OF THE WHAT 

363
00:14:10,350 --> 00:14:12,152
WE HAVE AROUND OUR DATA CENTERS 

364
00:14:12,152 --> 00:14:13,687
THAT PUTS TOGETHER A BLOG.  IF 

365
00:14:13,687 --> 00:14:14,654
YOU'RE INTERESTED IN WHAT ARE WE

366
00:14:14,654 --> 00:14:16,523
DOING IN CANCER DATA SCIENCE 

367
00:14:16,523 --> 00:14:18,492
THAT BLOG IS A REALLY GOOD ONE 

368
00:14:18,492 --> 00:14:19,793
TO FOLLOW AND KEEP TRACK OF 

369
00:14:19,793 --> 00:14:25,365
WHAT'S GOING ON IN THIS AREA.  

370
00:14:25,365 --> 00:14:26,967
OKAY, BUDGET.  SO, AGAIN, MY 

371
00:14:26,967 --> 00:14:28,702
BUDGET WILL JUST BE TALKING 

372
00:14:28,702 --> 00:14:33,874
ABOUT WHAT WE PROPOSED FOR THE 

373
00:14:33,874 --> 00:14:35,876
PROFESSIONAL JUDGMENT BUDGET.  

374
00:14:35,876 --> 00:14:39,212
NITTY-GRITTY COMING AFTER.  THE 

375
00:14:39,212 --> 00:14:41,915
ANNUAL PLAN IS WHAT WE CALL THE 

376
00:14:41,915 --> 00:14:42,516
PROFESSIONAL JUDGMENT BUDGET 

377
00:14:42,516 --> 00:14:45,652
PROPOSAL.  IT'S A TOOL TO SHARE 

378
00:14:45,652 --> 00:14:46,953
WITH CONGRESS WHAT WE'RE, AND 

379
00:14:46,953 --> 00:14:48,588
WITH THE PRESIDENT, WHAT WE'RE 

380
00:14:48,588 --> 00:14:51,358
DOING TO HELP TO BUILD 

381
00:14:51,358 --> 00:14:53,393
UNDERSTANDING AND TO CONVEY HOW 

382
00:14:53,393 --> 00:14:55,762
IMPORTANT IT IS THAT INVESTMENTS

383
00:14:55,762 --> 00:14:57,497
OCCUR IN CANCER RESEARCH.  

384
00:14:57,497 --> 00:14:59,666
YOU'LL BE SEEING A SERIES OF 

385
00:14:59,666 --> 00:15:00,867
E-MAILS YOU'VE ALREADY SEEN A 

386
00:15:00,867 --> 00:15:02,836
PREVIEW OF THE E-MAILS THAT WILL

387
00:15:02,836 --> 00:15:05,438
GO OUT TO OUR CONSTITUENTS BUT 

388
00:15:05,438 --> 00:15:08,575
SOCIAL MEDIA WE REALLY WANTED TO

389
00:15:08,575 --> 00:15:10,911
PLUG THIS DOCUMENT WHICH IS A 

390
00:15:10,911 --> 00:15:12,112
COMBINATION OF TEXT AS WELL AS 

391
00:15:12,112 --> 00:15:12,913
SOME SPREADSHEETS BECAUSE IT IS 

392
00:15:12,913 --> 00:15:14,948
A BUDGET.  WE TELL PART OF IT IN

393
00:15:14,948 --> 00:15:16,950
A STORY SO WE TELL THREE STORIES

394
00:15:16,950 --> 00:15:19,719
AND THE STORIES ARE LIKE ALL 

395
00:15:19,719 --> 00:15:21,955
STORIES, REALLY MEANT TO COVER 

396
00:15:21,955 --> 00:15:23,723
MORE THAN ONE MORAL IN THOSE 

397
00:15:23,723 --> 00:15:25,625
STORIES.  WE START WITH A 

398
00:15:25,625 --> 00:15:26,893
PATIENT BECAUSE PATIENTS COME 

399
00:15:26,893 --> 00:15:28,895
FIRST WHEN WE'RE TALKING ABOUT 

400
00:15:28,895 --> 00:15:30,330
CANCER AND CANCER RESEARCH.  WE 

401
00:15:30,330 --> 00:15:32,866
TELL THE STORY ABOUT A PATIENT 

402
00:15:32,866 --> 00:15:35,969
NAMED JASON WHO HAS 

403
00:15:35,969 --> 00:15:37,804
NON-HODGKIN'S LIMB POE IF A WHO 

404
00:15:37,804 --> 00:15:41,441
CAME FOR AN INNOVATIVE CANCER 

405
00:15:41,441 --> 00:15:44,211
CENTER AND IS NOW THREE YEARS 

406
00:15:44,211 --> 00:15:45,412
OUT DISEASE-FREE. 

407
00:15:45,412 --> 00:15:48,682
THAT STORY TELLS US WHY WE'RE 

408
00:15:48,682 --> 00:15:49,549
HERE.  WHAT IT IS THAT OUR 

409
00:15:49,549 --> 00:15:52,452
MISSION IS THERE TO ACCOMPLISH. 

410
00:15:52,452 --> 00:15:56,756
THE BIOLOGY OF TUMORS CAN MAKE A

411
00:15:56,756 --> 00:15:59,359
DIFFERENCE AND WE CAN CURE 

412
00:15:59,359 --> 00:16:00,894
PATIENTS AND DO SO WITH LESS 

413
00:16:00,894 --> 00:16:02,762
TOXIC SIDE EFFECTS WE ALSO TELL 

414
00:16:02,762 --> 00:16:05,232
A STORY ABOUT EARLY STAGE 

415
00:16:05,232 --> 00:16:08,001
INVESTIGATOR.  HER NAME IS LEAH 

416
00:16:08,001 --> 00:16:11,271
AND A MOON SHOT SCHOLAR AND A 

417
00:16:11,271 --> 00:16:14,641
VERY SUCCESSFUL PROGRAM TO BRING

418
00:16:14,641 --> 00:16:20,280
DIVERSITY INTO OUR WORKFORCE, TO

419
00:16:20,280 --> 00:16:22,616
ENABLE PEOPLE TO BE 

420
00:16:22,616 --> 00:16:23,183
INVESTIGATORS AND BRINGING 

421
00:16:23,183 --> 00:16:25,118
CERVICAL CANCER RESEARCH TO 

422
00:16:25,118 --> 00:16:26,920
LOWER AREAS.  AGAIN TELLING 

423
00:16:26,920 --> 00:16:27,988
ABOUT INVESTMENT AND THE VALUE 

424
00:16:27,988 --> 00:16:31,691
THAT WE PLACE ON TALENT 

425
00:16:31,691 --> 00:16:33,026
DEVELOPMENT.  THE IMPORTANCE OF 

426
00:16:33,026 --> 00:16:35,161
OUR COMMUNITY AND HOW 

427
00:16:35,161 --> 00:16:36,196
RESEARCHERS ENGAGE WITH THE 

428
00:16:36,196 --> 00:16:40,033
COMMUNITY AND HOW WE ADDRESS 

429
00:16:40,033 --> 00:16:41,334
SERIOUS ISSUES LIKE SOCIAL 

430
00:16:41,334 --> 00:16:42,636
DETERMINANTS OF HEALTH AND THEN 

431
00:16:42,636 --> 00:16:45,305
WE TELL A STORY ABOUT OUR SBIR. 

432
00:16:45,305 --> 00:16:48,308
OUR SMALL BUSINESS INNOVATION 

433
00:16:48,308 --> 00:16:49,442
RESEARCH PROGRAM AND A SMALL 

434
00:16:49,442 --> 00:16:51,645
COMPANY THAT'S STARTING TO LOOK 

435
00:16:51,645 --> 00:16:55,081
AT A MOLECULE THAT CAN DETECT 

436
00:16:55,081 --> 00:16:57,651
CANCER CELLS IN THE OPERATIVE 

437
00:16:57,651 --> 00:17:00,854
FIELD.  THIS IS SHOWCASING WHERE

438
00:17:00,854 --> 00:17:02,956
REALLY TECHNOLOGY BLENDS WITH 

439
00:17:02,956 --> 00:17:04,891
SCIENCE, INNOVATION AND 

440
00:17:04,891 --> 00:17:07,627
MEDICINE.  IT'S PART OF OUR 

441
00:17:07,627 --> 00:17:09,462
ECONOMIC ENGINE.  THIS IS A 

442
00:17:09,462 --> 00:17:10,964
SMALL COMPANY THAT WILL CREATE A

443
00:17:10,964 --> 00:17:12,999
VALUE ADDED RESOURCE THAT WILL 

444
00:17:12,999 --> 00:17:15,235
BE A PART OF THE OVERALL 

445
00:17:15,235 --> 00:17:18,538
OPERATION AND ECONOMIC IMPACT IS

446
00:17:18,538 --> 00:17:25,345
VERY, VERY REAL.  OKAY.  WE TELL

447
00:17:25,345 --> 00:17:28,281
THE STORIES IN SPREADSHEETS TOO.

448
00:17:28,281 --> 00:17:31,184
OUR TOTAL ASK IS ROUGHLY 11.5 

449
00:17:31,184 --> 00:17:32,886
BILLION DOLLARS.  THAT'S THE 

450
00:17:32,886 --> 00:17:34,054
NUMBER I WANT YOU TO REMEMBER.  

451
00:17:34,054 --> 00:17:35,689
WHERE DO WE COME ONE A NUMBER 

452
00:17:35,689 --> 00:17:37,324
LIKE THIS?  THIS IS AN 

453
00:17:37,324 --> 00:17:39,092
INVESTMENT IN CANCER RESEARCH 

454
00:17:39,092 --> 00:17:40,093
THAT CAN CAPITALIZE ON WHAT WE 

455
00:17:40,093 --> 00:17:41,728
HAVE AS OPPORTUNITIES TODAY.  

456
00:17:41,728 --> 00:17:44,497
WHICH YOU ALL AT THIS TABLE KNOW

457
00:17:44,497 --> 00:17:46,166
ARE REALLY TREMENDOUS.  IT ALSO 

458
00:17:46,166 --> 00:17:48,201
TELLS US ABOUT THE INCREDIBLE 

459
00:17:48,201 --> 00:17:50,837
RETURN THAT THERE IS ON 

460
00:17:50,837 --> 00:17:52,772
INVESTMENT.  THIS KIND OF 

461
00:17:52,772 --> 00:17:54,307
INCREASE IN OUR CURRENT BASE 

462
00:17:54,307 --> 00:17:56,309
COULD REALLY CHANGE WHAT WE CAN 

463
00:17:56,309 --> 00:18:00,714
DO IN AREAS OF PREVENTION.  IN 

464
00:18:00,714 --> 00:18:02,749
TRAINING.  IN DISCOVERY.  I WILL

465
00:18:02,749 --> 00:18:04,150
TELL YOU THAT THIS NUMBER IS THE

466
00:18:04,150 --> 00:18:07,354
SAME NUMBER THAT WE PUT UP LAST 

467
00:18:07,354 --> 00:18:08,621
YEAR.  WE SPENT A LOT OF TIME 

468
00:18:08,621 --> 00:18:10,690
TRYING TO DECIDE WHERE WE WERE 

469
00:18:10,690 --> 00:18:12,859
GOING TO LAND AND I WILL SHOW 

470
00:18:12,859 --> 00:18:14,728
YOU WHERE OUR CURRENT 

471
00:18:14,728 --> 00:18:15,829
APPROPRIATION IS IN COMPARISON 

472
00:18:15,829 --> 00:18:17,864
TO THIS AND IT FELT LIKE GIVING 

473
00:18:17,864 --> 00:18:20,100
AN EVEN BIGGER NUMBER REALLY 

474
00:18:20,100 --> 00:18:22,335
WASN'T WISE IN THIS CURRENT ERA.

475
00:18:22,335 --> 00:18:24,170
WE'RE TRYING TO SIGNAL THAT WE 

476
00:18:24,170 --> 00:18:26,172
GET IT.  WE UNDERSTAND THAT 

477
00:18:26,172 --> 00:18:28,875
THERE'S A FINANCIAL REALITY.  WE

478
00:18:28,875 --> 00:18:30,243
UNDERSTAND THAT THERE ARE REAL 

479
00:18:30,243 --> 00:18:32,879
ECONOMIC CONSTRAINTS FACING OUR 

480
00:18:32,879 --> 00:18:36,683
COUNTRY AND THE WORLD.  AND -- 

481
00:18:36,683 --> 00:18:40,587
BUT OUR GAP JUST CAN'T KEEP 

482
00:18:40,587 --> 00:18:42,288
WIDENING.  AND SO WE REALLY WANT

483
00:18:42,288 --> 00:18:44,891
TO SHOW ALSO THAT WE NEED A REAL

484
00:18:44,891 --> 00:18:46,159
INFUSION TO DO THE WORK THAT 

485
00:18:46,159 --> 00:18:47,994
PEOPLE ARE EXPECTING FROM US TO 

486
00:18:47,994 --> 00:18:52,132
DO.  THE RISK IF WE DON'T IS 

487
00:18:52,132 --> 00:18:53,033
LOSING OUR COMPETITIVE EDGE.  

488
00:18:53,033 --> 00:18:56,236
FALLING BEHIND COMPARED TO PEERS

489
00:18:56,236 --> 00:18:58,972
AND LOSING A GENERATION OF 

490
00:18:58,972 --> 00:19:01,875
WORKFORCE AND WE JUST CAN'T 

491
00:19:01,875 --> 00:19:03,510
AFFORD TO DO THAT.  EVERYTHING'S

492
00:19:03,510 --> 00:19:06,713
NOT EXACTLY THE SAME.  WE DID 

493
00:19:06,713 --> 00:19:07,380
TINKER WITH WHERE WE WERE GOING 

494
00:19:07,380 --> 00:19:09,115
TO MAKE SOME OF OUR INVESTMENTS 

495
00:19:09,115 --> 00:19:10,984
AGAIN IN AREAS WE THINK ARE 

496
00:19:10,984 --> 00:19:12,886
REALLY POOR LIKE PREVENTION, 

497
00:19:12,886 --> 00:19:16,222
LIKE TRAINING.  BUT EVERYTHING 

498
00:19:16,222 --> 00:19:19,692
NEEDS A BOOST.  WE ALSO IN THE 

499
00:19:19,692 --> 00:19:20,794
ANNUAL PLAN GET THE OPPORTUNITY 

500
00:19:20,794 --> 00:19:22,162
TO HIGHLIGHT SOME AREAS TA WE 

501
00:19:22,162 --> 00:19:24,831
WOULD LIKE TO FOCUS ON.  SO JUST

502
00:19:24,831 --> 00:19:28,168
SOME EXAMPLES, TACKLING THE 

503
00:19:28,168 --> 00:19:32,605
EMERGENCE OF EARLY ONSET OF 

504
00:19:32,605 --> 00:19:34,174
CANCERS, AN IMPORTANT AREA WHERE

505
00:19:34,174 --> 00:19:35,742
WE CAN LEARN ABOUT COMMON AND 

506
00:19:35,742 --> 00:19:37,477
RARE CANCERS AND SO WE HIGHLIGHT

507
00:19:37,477 --> 00:19:38,878
THAT THIS IS AN AREA THAT WE 

508
00:19:38,878 --> 00:19:42,115
THINK IS DESERVING ADDITIONAL 

509
00:19:42,115 --> 00:19:43,583
FOCUS.  APPROACHING CANCER IS A 

510
00:19:43,583 --> 00:19:44,884
DISEASE THAT AFFECTS THE WHOLE 

511
00:19:44,884 --> 00:19:47,720
BODY.  A POINT TO LOOKING AT 

512
00:19:47,720 --> 00:19:48,788
SURVIVORSHIP ISSUES BUT ALSO 

513
00:19:48,788 --> 00:19:52,125
THINKING ABOUT THINGS LIKE HOW 

514
00:19:52,125 --> 00:19:53,793
THE H TAN PROGRAM, LOOKING AT 

515
00:19:53,793 --> 00:19:55,495
THE INTERSECTION BETWEEN CELLS 

516
00:19:55,495 --> 00:19:58,231
IN THE IMMUNE SYSTEM IS REALLY 

517
00:19:58,231 --> 00:20:00,033
VITAL FOR US TO MAKE THE 

518
00:20:00,033 --> 00:20:02,669
DIFFERENCES THAT WE WANT.  

519
00:20:02,669 --> 00:20:05,038
ALLEVIATING FINANCIAL TOXICITY. 

520
00:20:05,038 --> 00:20:06,773
LOOKING AT THE ROOT CAUSES AND 

521
00:20:06,773 --> 00:20:09,342
HOW TO COMBAT THEM FOR PEOPLE TO

522
00:20:09,342 --> 00:20:10,577
GET THE THERAPY THAT THEY NEED 

523
00:20:10,577 --> 00:20:12,912
AND HAVE THE HEALTH CARE THAT 

524
00:20:12,912 --> 00:20:14,647
THEY DESERVE.  AND EXPANDING ON 

525
00:20:14,647 --> 00:20:16,983
THE UTILITY OF VACCINES.  WE'VE 

526
00:20:16,983 --> 00:20:19,752
SEEN THE PROMISE OF VACCINES 

527
00:20:19,752 --> 00:20:21,454
DELIVER FOR PREVENTION BUT THEY 

528
00:20:21,454 --> 00:20:22,655
CAN DELIVER AS WELL FOR 

529
00:20:22,655 --> 00:20:24,157
TREATMENT AND THOSE ARE 

530
00:20:24,157 --> 00:20:24,824
INCREDIBLE OPPORTUNITIES SO THIS

531
00:20:24,824 --> 00:20:28,194
IS JUST THE REAL SPREADSHEET TO 

532
00:20:28,194 --> 00:20:29,863
SHOW WHERE THINGS COMPARE TO 

533
00:20:29,863 --> 00:20:30,630
PROFESSIONAL JUDGMENT BUDGETS 

534
00:20:30,630 --> 00:20:32,465
OVER THE LAST FEW YEARS AND 

535
00:20:32,465 --> 00:20:38,138
WHERE WE ARE TODAY.  SO IN '23 

536
00:20:38,138 --> 00:20:39,639
OUR PROFESSIONAL JUDGMENT BUDGET

537
00:20:39,639 --> 00:20:42,041
WAS FOR 7.4 BILLION.  WE 

538
00:20:42,041 --> 00:20:43,643
RECEIVED 7.3.  THERE WAS A GAP 

539
00:20:43,643 --> 00:20:46,312
BUT NOT ENORMOUS.  IT REALLY 

540
00:20:46,312 --> 00:20:49,582
STARTED TO RISE LAST YEAR FY24 

541
00:20:49,582 --> 00:20:50,416
WHEN THE PROFESSIONAL JUDGMENT 

542
00:20:50,416 --> 00:20:53,786
WAS 9.9 BUT WE HAD A DECREASE 

543
00:20:53,786 --> 00:20:56,589
BECAUSE OF THE ENDING OF THE 

544
00:20:56,589 --> 00:20:58,525
CARES ACT BUT THE NET CHANGE WAS

545
00:20:58,525 --> 00:21:01,227
A 96 MILLION DOLLARS DECREASE.  

546
00:21:01,227 --> 00:21:04,731
THE FY25 WAS THE 11.5 BILLION 

547
00:21:04,731 --> 00:21:07,233
AND THAT'S WHERE WE'RE HOLDING 

548
00:21:07,233 --> 00:21:10,637
FOR FY 26.  SO WHERE WE 

549
00:21:10,637 --> 00:21:11,638
INVESTING WITH THE DOLLARS THAT 

550
00:21:11,638 --> 00:21:12,372
WE HAVE?

551
00:21:12,372 --> 00:21:13,673
I WANT TO MAKE SURE THAT WHAT 

552
00:21:13,673 --> 00:21:16,242
YOU HEAR IS THAT WE ARE ALL IN 

553
00:21:16,242 --> 00:21:19,345
ON TRAINING AND ON EARLY STAGE 

554
00:21:19,345 --> 00:21:20,079
INVESTIGATOR TALENT AND 

555
00:21:20,079 --> 00:21:21,648
DEVELOPMENT.  I SHOWED YOU THIS 

556
00:21:21,648 --> 00:21:23,216
SLIDE BEFORE I THINK.  I HAVE 

557
00:21:23,216 --> 00:21:25,018
SHOWN THIS SLIDE A FEW TIMES NOW

558
00:21:25,018 --> 00:21:28,254
SHOWING WHERE WE MAKE DECISIONS 

559
00:21:28,254 --> 00:21:28,888
ABOUT PLANNING EARLY STAGE 

560
00:21:28,888 --> 00:21:31,257
INVESTIGATORS ALTHOUGH OUR PAY 

561
00:21:31,257 --> 00:21:33,493
LINE IS TEN, WE KEPT THE EARLY 

562
00:21:33,493 --> 00:21:37,397
STAGE INVESTIGATOR PAY LINE AT 

563
00:21:37,397 --> 00:21:39,132
17%.  WE'RE REALLY STILL 

564
00:21:39,132 --> 00:21:40,867
COMMITTED TO FUNDING AT LEAST AS

565
00:21:40,867 --> 00:21:42,602
MANY EARLY STAGE INVESTIGATORS 

566
00:21:42,602 --> 00:21:46,406
THIS YEAR AS WE DID LAST YEAR.  

567
00:21:46,406 --> 00:21:51,010
THAT'S MEANT REALLOCATING SOME 

568
00:21:51,010 --> 00:21:52,612
RESOURCES TO MAKE SURE WE'RE 

569
00:21:52,612 --> 00:21:54,747
FUNDING AT LEAST AS MANY AS 

570
00:21:54,747 --> 00:21:58,284
BEFORE.  REMEMBER, GRANTS GET 

571
00:21:58,284 --> 00:22:00,253
BIG SOGER SO THAT MEANS MORE 

572
00:22:00,253 --> 00:22:02,488
DOLLARS AND THE RATE IS STILL 

573
00:22:02,488 --> 00:22:03,189
PROJECTED BECAUSE THERE'S A FEW 

574
00:22:03,189 --> 00:22:06,059
MORE THAT IS 19%.  SO FOR EARLY 

575
00:22:06,059 --> 00:22:07,594
STAGE INVESTIGATORS THAT ARE OUT

576
00:22:07,594 --> 00:22:09,128
THERE, WE'RE INVESTING IN YOU 

577
00:22:09,128 --> 00:22:10,396
AND WE REALLY WANT YOU TO BE 

578
00:22:10,396 --> 00:22:12,899
PART OF OUR COMMUNITY AND SO 

579
00:22:12,899 --> 00:22:17,570
THIS IS HOW WE SHOW THAT.  SO, 

580
00:22:17,570 --> 00:22:20,873
JUST A REMINDER, THE NATIONAL 

581
00:22:20,873 --> 00:22:22,809
CANCER PLAN THIS IS OUR ROADMAP 

582
00:22:22,809 --> 00:22:24,444
AND THIS HELPS US STAY ON TRACK.

583
00:22:24,444 --> 00:22:28,314
WE'RE FOCUSING RIGHT NOW ON 

584
00:22:28,314 --> 00:22:31,384
OPTIMIZING THE WORKFORCE.  WE'RE

585
00:22:31,384 --> 00:22:32,285
FOCUSING ON EVERYTHING BUT TODAY

586
00:22:32,285 --> 00:22:37,190
FOCUSING ON OOPT M OPTIMIZING T 

587
00:22:37,190 --> 00:22:38,691
WORKFORCE.  WE'RE HEARING ABOUT 

588
00:22:38,691 --> 00:22:42,829
TRAINING BUT ALSO ABOUT NCORP 

589
00:22:42,829 --> 00:22:44,631
AND THAT'S A HUGE PART OF OUR 

590
00:22:44,631 --> 00:22:47,667
WORKFORCE AND THE FOCUS ON OUR 

591
00:22:47,667 --> 00:22:48,735
COMMUNITY ENGAGEMENT WILL BE ON 

592
00:22:48,735 --> 00:22:49,402
OPTIMIZING THE WORKFORCE SO LOOK

593
00:22:49,402 --> 00:22:50,603
OUT FOR OUR SOCIAL MEDIA POSTS, 

594
00:22:50,603 --> 00:22:52,238
PLEASE JOIN US, I KNOW THAT THIS

595
00:22:52,238 --> 00:22:54,040
IS AN IMPORTANT TOPIC FOR 

596
00:22:54,040 --> 00:22:55,174
EVERYONE IN THIS ROOM.  JUST A 

597
00:22:55,174 --> 00:22:56,876
FEW EXAMPLES OF HOW WE'RE 

598
00:22:56,876 --> 00:23:00,013
PRIORITIZING OPTIMIZING THE 

599
00:23:00,013 --> 00:23:02,582
WORKFORCE.  WE'RE THINKING ABOUT

600
00:23:02,582 --> 00:23:05,618
INTERESTING WAYS THAT WE SUPPORT

601
00:23:05,618 --> 00:23:08,354
TRAINING AND WORKFORCE R15 IS A 

602
00:23:08,354 --> 00:23:10,290
PROGRAM THAT I ENCOURAGE YOU TO 

603
00:23:10,290 --> 00:23:12,392
LOOK AT IN THE CANCER BLOG IT'S 

604
00:23:12,392 --> 00:23:16,162
A PROGRAM LIKE AN RO 1 BUT FOR 

605
00:23:16,162 --> 00:23:17,063
INSTITUTIONS THAT DON'T HAVE 

606
00:23:17,063 --> 00:23:18,598
HIGH LEVELS OF FUNDING WHICH 

607
00:23:18,598 --> 00:23:22,302
SUPPORTS INVESTIGATORS WITH A 

608
00:23:22,302 --> 00:23:24,304
PROGRAM BUILT INTO IT TO DEVELOP

609
00:23:24,304 --> 00:23:26,239
TYPICALLY UNDERGRADUATE 

610
00:23:26,239 --> 00:23:26,873
STUDENTS.  VERY SUCCESSFUL AND 

611
00:23:26,873 --> 00:23:29,742
VERY REWARDING TO LEARN ABOUT.  

612
00:23:29,742 --> 00:23:32,045
WE'RE ALSO PARTNERING WHERE WE 

613
00:23:32,045 --> 00:23:34,314
CAN.  IT'S AN ENTIRE ECOSYSTEM 

614
00:23:34,314 --> 00:23:36,816
FOR CANCER.  SO THE CATALYST 

615
00:23:36,816 --> 00:23:43,289
AWARD WAS JUST ANNOUNCED BY THE 

616
00:23:43,289 --> 00:23:43,990
AMERICAN CANCER SOCIETY.  THEY 

617
00:23:43,990 --> 00:23:45,491
ARE WORKING WITH US TO HELP THEM

618
00:23:45,491 --> 00:23:47,827
GET FUNDED.  SO WE WERE ABLE TO 

619
00:23:47,827 --> 00:23:50,096
GET UP TO CLOSE TO 19.  SO -- 

620
00:23:50,096 --> 00:23:51,564
BUT THERE'S STILL GRANTS IN THAT

621
00:23:51,564 --> 00:23:53,866
SPACE.  STILL WELL DESERVING 

622
00:23:53,866 --> 00:23:55,501
AWARDS AND SO THEY'RE HELPING 

623
00:23:55,501 --> 00:23:57,737
HOWEVER THOSE INDIVIDUALS GET 

624
00:23:57,737 --> 00:23:58,705
FUNDED IS IMPORTANT.  

625
00:23:58,705 --> 00:24:03,943
AND JUST ENCOURAGE YOU TO FOLLOW

626
00:24:03,943 --> 00:24:07,747
OLIVER BOWING HER WHO PUT OUT A 

627
00:24:07,747 --> 00:24:10,316
BLOG IN THE NCI BOTTOM LINE ON 

628
00:24:10,316 --> 00:24:12,185
THE COMMITMENT TO CANCER 

629
00:24:12,185 --> 00:24:13,519
TRAINING WE'RE NOT THE ONLY ONES

630
00:24:13,519 --> 00:24:15,888
INTERESTED IN THIS.  THE 

631
00:24:15,888 --> 00:24:17,924
PRESIDENT'S CANCER PANEL IS 

632
00:24:17,924 --> 00:24:19,692
FOCUSING IN JUST A FEW WEEKS ON 

633
00:24:19,692 --> 00:24:21,260
THEIR PROGRAM.  ACTUALLY IT'S 

634
00:24:21,260 --> 00:24:22,328
NEXT WEEK ALREADY.  IN 

635
00:24:22,328 --> 00:24:24,063
DEVELOPING A RETAINING A ROBUST 

636
00:24:24,063 --> 00:24:27,367
CANCER WORKFORCE.  IT'S A TWO 

637
00:24:27,367 --> 00:24:28,401
PART OPEN DIALOGUE AND REALLY 

638
00:24:28,401 --> 00:24:29,802
ENCOURAGE YOU TO WATCH THAT AND 

639
00:24:29,802 --> 00:24:34,107
BE A PART OF IT.  AND THEN JUST 

640
00:24:34,107 --> 00:24:36,642
TO GIVE YOU SOME HIGHLIGHTS.  

641
00:24:36,642 --> 00:24:38,544
THERE'S SO MUCH GOING ON IN THE 

642
00:24:38,544 --> 00:24:39,545
REALM OF CANCER RESEARCH.  I 

643
00:24:39,545 --> 00:24:41,314
JUST WANT TO MAKE SURE YOU KNOW 

644
00:24:41,314 --> 00:24:43,416
THAT WE'RE NOT KEEPING -- LOSING

645
00:24:43,416 --> 00:24:45,485
OUR SIGHT ON THE BALL OF HOW WE 

646
00:24:45,485 --> 00:24:49,922
MAKE REAL EXCITING ADVANCES.  IN

647
00:24:49,922 --> 00:24:53,393
IMMUNOTHERAPY.  WE SAW THE FIRST

648
00:24:53,393 --> 00:24:56,095
FDA APPROVAL FOR SARCOMA.  WE 

649
00:24:56,095 --> 00:25:01,501
SAW NEW FDA APPROVED THERAPY FOR

650
00:25:01,501 --> 00:25:02,668
ENDOMETRIAL CANCER ON TOP OF 

651
00:25:02,668 --> 00:25:04,270
THAT CANCER WITH THE WOMEN'S 

652
00:25:04,270 --> 00:25:07,140
HEALTH INITIATIVE WE TOOK A LOOK

653
00:25:07,140 --> 00:25:12,879
AT WHAT OUR PORTFOLIO WAS AND IT

654
00:25:12,879 --> 00:25:15,014
WAS POOR AND WE GOT AN 

655
00:25:15,014 --> 00:25:16,349
OVERWHELMING RESPONSE FOR 

656
00:25:16,349 --> 00:25:17,383
SUPPLEMENTS WE'RE TRYING TO 

657
00:25:17,383 --> 00:25:19,819
BOOST THAT PIELINE VERY 

658
00:25:19,819 --> 00:25:20,686
EFFECTIVELY.  

659
00:25:20,686 --> 00:25:24,590
THE RAS INITIATIVE HAS REALLY 

660
00:25:24,590 --> 00:25:26,192
BEGUN, WELL JUST BEGUN BUT IS 

661
00:25:26,192 --> 00:25:28,895
SHOWING TREMENDOUS OUTPUTS.  NOW

662
00:25:28,895 --> 00:25:30,630
WITH NEW INFORMATION ABOUT THE 

663
00:25:30,630 --> 00:25:34,367
STRUCTURE AND FUNCTION OF THE 

664
00:25:34,367 --> 00:25:38,971
KRAS 4 A VARIANT BUT ALSO THE 

665
00:25:38,971 --> 00:25:42,108
DISCOVERY OF CRAS G12C.  WE HAVE

666
00:25:42,108 --> 00:25:45,077
A NEW ANALYSIS THAT HAS GOTTEN A

667
00:25:45,077 --> 00:25:47,180
CLAIM IN THE PUBLIC PRESS THAT 

668
00:25:47,180 --> 00:25:48,881
SHOWS THAT THE COST OF CANCER 

669
00:25:48,881 --> 00:25:50,983
SCREENING ALTHOUGH THAT'S A BIG 

670
00:25:50,983 --> 00:25:51,617
NUMBER 43 BILLION DOLLARS FOR 

671
00:25:51,617 --> 00:25:52,819
THE U.S. ECONOMY. 

672
00:25:52,819 --> 00:25:54,987
THE COST OF SCREENING IS LESS 

673
00:25:54,987 --> 00:25:57,390
THAN THE COST OF TREATMENT.  AND

674
00:25:57,390 --> 00:25:59,492
WE KNOW THAT NOT HAVING CANCER 

675
00:25:59,492 --> 00:26:02,428
OR HAVING A CANCER THAT WE 

676
00:26:02,428 --> 00:26:04,363
DETECT AND MANAGE MORE EARLIER 

677
00:26:04,363 --> 00:26:07,533
IS BETTER THAN TREATING A MORE 

678
00:26:07,533 --> 00:26:10,603
ADVANCED CANCER.  SO WHAT DO I 

679
00:26:10,603 --> 00:26:16,876
NEED FROM YOU TODAY?  WELL WE 

680
00:26:16,876 --> 00:26:19,779
HAVE A NEW CENTER TO FOCUS 

681
00:26:19,779 --> 00:26:20,480
COMMUNICATION.  WHERE WOULD YOU 

682
00:26:20,480 --> 00:26:22,281
LIKE TO SEE MORE EFFORTS IN THAT

683
00:26:22,281 --> 00:26:23,349
SPACE AS I WOULD LIKE TO HEAR 

684
00:26:23,349 --> 00:26:25,685
NOW OR IN THE FUTURE.  YOUR 

685
00:26:25,685 --> 00:26:26,552
THOUGHTS OF MEETING THE NEEDS OF

686
00:26:26,552 --> 00:26:28,287
AND THIS IS THE TOPICS THAT WE 

687
00:26:28,287 --> 00:26:29,455
WILL TALK ABOUT TODAY SO THIS 

688
00:26:29,455 --> 00:26:31,290
CAN BE HERE BUT ALSO IN OUR 

689
00:26:31,290 --> 00:26:33,459
SEGMENTS LATER, WORKFORCE, AI 

690
00:26:33,459 --> 00:26:34,560
ADVANCES, COMMUNITY BASED 

691
00:26:34,560 --> 00:26:38,965
ONCOLOGY RESEARCH AND PEDIATRIC 

692
00:26:38,965 --> 00:26:43,336
ONCOLOGY.  AND THE THING WE TALK

693
00:26:43,336 --> 00:26:44,871
ABOUT MORE IS BUDGET.  WE WOULD 

694
00:26:44,871 --> 00:26:47,807
LIKE TO TRAIN MORE, CURE MORE 

695
00:26:47,807 --> 00:26:51,377
CANCERS AND SO HOW DO WE BEST 

696
00:26:51,377 --> 00:26:52,745
LEVERAGE THOSE RESOURCES, FORM 

697
00:26:52,745 --> 00:26:53,579
NEW PARTNERSHIPS AND REALLY HAVE

698
00:26:53,579 --> 00:26:55,681
THE RESOURCES TO BE ABLE TO DO 

699
00:26:55,681 --> 00:26:57,383
WHAT WE WANT TO DO AND SO 

700
00:26:57,383 --> 00:26:58,050
ALWAYS, I WILL TAKE SUGGESTIONS 

701
00:26:58,050 --> 00:27:01,888
FOR HOW WE MOVE FORWARD FASTER. 

702
00:27:01,888 --> 00:27:04,457
WITH THAT I WILL TAKE SOME 

703
00:27:04,457 --> 00:27:05,625
QUESTIONS.

704
00:27:05,625 --> 00:27:08,861
>> GREAT, THANKS, KIM. 
FLOOR'S 

705
00:27:08,861 --> 00:27:10,463
NOW OPEN FOR QUESTIONS FROM THE 

706
00:27:10,463 --> 00:27:17,670
BOARD.  SO I HAVE ONE, YOU POKE 

707
00:27:17,670 --> 00:27:18,304
ABOUT COMPETITIVE ADVANTAGE I 

708
00:27:18,304 --> 00:27:20,873
THINK THAT IS REALLY IMPORTANT. 

709
00:27:20,873 --> 00:27:21,841
THAT DEFINITELY RESONATES WITH 

710
00:27:21,841 --> 00:27:23,543
ME HAS THERE BEEN ANY TYPE OF 

711
00:27:23,543 --> 00:27:24,877
ANALYSIS TO LOOK AT COMPARISONS 

712
00:27:24,877 --> 00:27:28,047
IN TERMS OF INVESTMENT IN CANCER

713
00:27:28,047 --> 00:27:31,350
RESEARCH COMPARING AGAINST OTHER

714
00:27:31,350 --> 00:27:34,487
COUNTRIES WITH HIGH GDPS?  

715
00:27:34,487 --> 00:27:39,659
EUROPE?  UK?  CHINA?  HOW DO WE 

716
00:27:39,659 --> 00:27:39,892
COMPARE?

717
00:27:39,892 --> 00:27:42,361
>> WE'RE STILL THE BIGGEST

718
00:27:42,361 --> 00:27:44,897
FUNDER OF CANCER RESEARCH 

719
00:27:44,897 --> 00:27:46,499
WORLDWIDE BUT THAT'S ON A PER 

720
00:27:46,499 --> 00:27:49,535
CAPITA BASIS AND ON HOW IT 

721
00:27:49,535 --> 00:27:52,471
COMPARES TO PORTIONS OF THE 

722
00:27:52,471 --> 00:27:53,940
BUDGET I WOULD NEED TO DIVE 

723
00:27:53,940 --> 00:27:54,140
INTO.

724
00:27:54,140 --> 00:27:57,376
>> WOULD BE INTERESTED TO
SEE 

725
00:27:57,376 --> 00:27:57,777
THAT.

726
00:27:57,777 --> 00:27:59,178
>> IT'S BECOME MORE
COMPETITIVE 

727
00:27:59,178 --> 00:28:00,880
AND WHERE'S THE FUNDING COME 

728
00:28:00,880 --> 00:28:07,820
FROM, YEAH.

729
00:28:07,820 --> 00:28:12,058
>> I HAVE A QUESTION. 
WHEN -- 

730
00:28:12,058 --> 00:28:13,259
THANK YOU FOR THE EXCELLENT 

731
00:28:13,259 --> 00:28:14,360
REPORT.  WHEN YOU WERE VISITING 

732
00:28:14,360 --> 00:28:15,528
WITH OTHER COMMUNITY PARTNERS AS

733
00:28:15,528 --> 00:28:18,264
YOU MENTIONED IN THE FIRST 

734
00:28:18,264 --> 00:28:20,566
SLIDE.  DID YOU SEE ANYMORE 

735
00:28:20,566 --> 00:28:21,734
OPPORTUNITIES FOR COMMUNICATION?

736
00:28:21,734 --> 00:28:23,736
DID THEY FEEL LIKE THEY WERE 

737
00:28:23,736 --> 00:28:26,939
HEARING FROM THE NCI BECAUSE I 

738
00:28:26,939 --> 00:28:30,176
AM NOT SURE THAT PEOPLE FEEL 

739
00:28:30,176 --> 00:28:31,911
CONNECTED, YOU KNOW, AT THAT 

740
00:28:31,911 --> 00:28:32,111
LEVEL.

741
00:28:32,111 --> 00:28:35,581
>> THAT CAME UP A FEW
TIMES THAT

742
00:28:35,581 --> 00:28:38,250
THAT THEY ARE LOOKING FOR MORE 

743
00:28:38,250 --> 00:28:40,252
AREAS OF HOW TO CONNECT.  WE HAD

744
00:28:40,252 --> 00:28:42,188
THAT CONVERSATION SEVERAL TIMES.

745
00:28:42,188 --> 00:28:47,660
BOTH IN KANSAS AND IN NEW YORK. 

746
00:28:47,660 --> 00:28:49,295
YOU KNOW, THAT THIS IS ONE OF 

747
00:28:49,295 --> 00:28:50,663
THE HARDEST THINGS THAT I THINK 

748
00:28:50,663 --> 00:28:55,067
THAT WE DO IS HOW DO WE 

749
00:28:55,067 --> 00:28:58,337
PENETRATE INTO THE INCREDIBLE 

750
00:28:58,337 --> 00:28:59,338
AMOUNT OF INFORMATION THAT IS 

751
00:28:59,338 --> 00:29:01,974
OUT THERE AND THAT'S BY HAVING 

752
00:29:01,974 --> 00:29:03,209
GOOD TRUSTWORTHY INFORMATION SO 

753
00:29:03,209 --> 00:29:06,512
WE PRIORITIZE THAT BUT ALSO 

754
00:29:06,512 --> 00:29:07,747
FINDING WAYS TO REACH PEOPLE 

755
00:29:07,747 --> 00:29:10,516
WHERE THEY ARE.  WHERE THEY'RE 

756
00:29:10,516 --> 00:29:12,018
LOOKING FOR INFORMATION SO WE'RE

757
00:29:12,018 --> 00:29:13,853
SPENDING A LOT OF TIME TRYING TO

758
00:29:13,853 --> 00:29:17,289
LEARN ABOUT HOW WE BEST REACH 

759
00:29:17,289 --> 00:29:18,824
PEOPLE ESPECIALLY A BUSY 

760
00:29:18,824 --> 00:29:21,093
COMMUNITY ONCOLOGIST WHO IS OUT 

761
00:29:21,093 --> 00:29:23,262
IN THE WESTERN PART OF KANSAS, 

762
00:29:23,262 --> 00:29:24,764
RIGHT, HOW DO WE COMMUNICATE?  

763
00:29:24,764 --> 00:29:26,065
IT NEEDS TO BE THROUGH THE 

764
00:29:26,065 --> 00:29:28,034
CANCER CENTER.  I'M SO GLAD TO 

765
00:29:28,034 --> 00:29:30,970
HEAR ABOUT THE NETWORK THAT THEY

766
00:29:30,970 --> 00:29:34,106
HAVE SO THAT IS ONE PART OF IT 

767
00:29:34,106 --> 00:29:36,075
BUT HOW TO MAKE SURE THE 

768
00:29:36,075 --> 00:29:37,843
MESSAGES DON'T GET LOST IN THAT 

769
00:29:37,843 --> 00:29:39,011
CHAIN SO THEY GET ALL THE WAY TO

770
00:29:39,011 --> 00:29:40,546
THE PEOPLE THAT NEED THEM.

771
00:29:40,546 --> 00:29:44,250
>> I THINK AS FAR AS YOUR
ASK OF

772
00:29:44,250 --> 00:29:46,018
US THAT MIGHT BE A PRIMARY 

773
00:29:46,018 --> 00:29:46,285
PRIORITY.

774
00:29:46,285 --> 00:29:48,020
>> I WILL TAKE THAT ONE.

775
00:29:48,020 --> 00:29:50,089
>> ANN HAS A QUESTION FROM
THE 

776
00:29:50,089 --> 00:29:51,791
VIRTUAL ROOM.

777
00:29:51,791 --> 00:29:55,628
>> HI, WONDERFUL,
WONDERFUL 

778
00:29:55,628 --> 00:29:57,596
INSPIRATIONAL, A LOT OF GREAT 

779
00:29:57,596 --> 00:29:59,865
THINGS.  I WANT TO CONGRATULATE 

780
00:29:59,865 --> 00:30:00,900
PETER.  HE'S DONE SUCH A GREAT 

781
00:30:00,900 --> 00:30:02,702
JOB ALL THESE YEARS BUT I WANTED

782
00:30:02,702 --> 00:30:08,874
TO JUST MAKE A SUGGESTION, KIM, 

783
00:30:08,874 --> 00:30:11,143
THE -- IT IS INTERESTING WE HAVE

784
00:30:11,143 --> 00:30:12,545
A PROGRAM CALL THE SCIENTIST 

785
00:30:12,545 --> 00:30:14,447
SURVIVE PROGRAM.  WE STARTED 

786
00:30:14,447 --> 00:30:15,981
SOME EDUCATION PROGRAMS FOR 

787
00:30:15,981 --> 00:30:20,886
ADVOCATES ABOUT THREE YEARS AGO 

788
00:30:20,886 --> 00:30:26,192
AND WE'RE NOTICING A PROGRAM, WE

789
00:30:26,192 --> 00:30:29,595
HAD UP TO 30 COUNTRIES SIGN UP 

790
00:30:29,595 --> 00:30:32,732
TO THESE SO THE WHOLE ADVOCACY 

791
00:30:32,732 --> 00:30:35,167
MOVEMENT IS MOVING IN AN 

792
00:30:35,167 --> 00:30:36,135
INTERNATIONAL DIRECTION AND AS 

793
00:30:36,135 --> 00:30:38,838
YOU BUILD THESE ALLIANCE, IF, 

794
00:30:38,838 --> 00:30:40,573
YOU KNOW, I THINK PETER 

795
00:30:40,573 --> 00:30:41,974
ESPECIALLY AND A WHOLE GROUP 

796
00:30:41,974 --> 00:30:44,243
THERE AT NCI SHOULD FOCUS ON HOW

797
00:30:44,243 --> 00:30:47,680
DO WE ACTUALLY SEND THAT INTO A 

798
00:30:47,680 --> 00:30:49,515
REAL INFLUENCE IN THESE VARIANCE

799
00:30:49,515 --> 00:30:50,282
COUNTRIES?  I THINK IT'S A REAL 

800
00:30:50,282 --> 00:30:56,222
UNTAPPED RESOURCE.

801
00:30:56,222 --> 00:30:57,389
>> YEAH THAT'S A REALLY
GOOD 

802
00:30:57,389 --> 00:30:58,591
POINT AND I WILL BUILD ON THAT 

803
00:30:58,591 --> 00:31:00,292
AND BRING IT BACK TO MORE LOCAL 

804
00:31:00,292 --> 00:31:03,596
IS ASK HOW VALUABLE IT IS TO 

805
00:31:03,596 --> 00:31:05,331
HAVE ADVOCATES AT THE TABLE.  AT

806
00:31:05,331 --> 00:31:07,700
THE RETREAT WE HAD THIS SUMMER 

807
00:31:07,700 --> 00:31:10,202
WE HAD OUR CHAIR OF ADVOCACY 

808
00:31:10,202 --> 00:31:12,304
COMMITTEE AND ALSO ANOTHER 

809
00:31:12,304 --> 00:31:13,506
ADVOCATE BROUGHT IN BY A WORKING

810
00:31:13,506 --> 00:31:14,340
GROUP AND HAVING THEM IN THE 

811
00:31:14,340 --> 00:31:20,880
ROOM WAS REALLY, REALLY 

812
00:31:20,880 --> 00:31:24,083
POWERFUL, THEY WERE FANTASTIC IN

813
00:31:24,083 --> 00:31:25,584
THE QUESTIONS THEY ASKED AND THE

814
00:31:25,584 --> 00:31:28,387
WAYS THEY PUSHED THE GROUP TO 

815
00:31:28,387 --> 00:31:31,023
MAKE IT HARDER.  I DON'T THINK 

816
00:31:31,023 --> 00:31:32,224
IT WOULD HAVE BEEN THE SAME 

817
00:31:32,224 --> 00:31:34,126
MEETING WITHOUT THEIR VOICES 

818
00:31:34,126 --> 00:31:34,326
THERE.

819
00:31:34,326 --> 00:31:38,297
>> SO WE HAVE MISS
ANDERSON AND 

820
00:31:38,297 --> 00:31:40,499
THEN KNOW LA.  MAKE SURE YOU 

821
00:31:40,499 --> 00:31:42,201
BRING THAT MIC REAL CLOSE.

822
00:31:42,201 --> 00:31:44,336
>> THANK YOU FOR THE 

823
00:31:44,336 --> 00:31:45,471
PRESENTATION, SO MY QUESTION 

824
00:31:45,471 --> 00:31:48,507
RELATE TO THE STUDY ON THE COST 

825
00:31:48,507 --> 00:31:50,109
OF CANCER SCREENING BEING 

826
00:31:50,109 --> 00:31:50,810
CHEEPER THAN THE TOTAL COST OF 

827
00:31:50,810 --> 00:31:56,315
TREATMENT.  DO YOU -- CAN YOU 

828
00:31:56,315 --> 00:32:04,456
ELABORATE MORE ON HOW THEY 

829
00:32:04,456 --> 00:32:06,325
RELATE BACK TO PROGRAMS AND 

830
00:32:06,325 --> 00:32:07,393
DIFFERENT ADVOCACY EFFORTS.  

831
00:32:07,393 --> 00:32:08,360
THAT'S A POWERFUL ONE AND I'VE 

832
00:32:08,360 --> 00:32:16,669
HAD CONVERSATIONS WITH YOU, MY 

833
00:32:16,669 --> 00:32:17,503
HUSBAND WAS DIAGNOSED EARLY WITH

834
00:32:17,503 --> 00:32:23,442
A LUNGS CANCER CT SCREENING THAT

835
00:32:23,442 --> 00:32:25,010
HE HAD EARLIER WHICH HE WOULD 

836
00:32:25,010 --> 00:32:26,378
HAVE NOTICED EARLIER IF HE WOULD

837
00:32:26,378 --> 00:32:29,148
HAVE LISTENED TO ME.  THAT WAS 

838
00:32:29,148 --> 00:32:32,151
ONE OF THOSE KEY EARLY SCREENING

839
00:32:32,151 --> 00:32:33,419
TOOLS THAT PHYSICIANS ARE NOT 

840
00:32:33,419 --> 00:32:34,720
TALKING ABOUT ENOUGH AND I AM 

841
00:32:34,720 --> 00:32:37,823
SURE HIS TOTAL COST OF CANCER 

842
00:32:37,823 --> 00:32:38,757
TREATMENT WILL BE MUCH HIGHER 

843
00:32:38,757 --> 00:32:40,659
THAN IF HE HAD GOTTEN THE TEST 

844
00:32:40,659 --> 00:32:42,962
TWO YEARS AGO.  SO WHAT ARE 

845
00:32:42,962 --> 00:32:44,663
YOUR -- THOUGHTS ON THAT.

846
00:32:44,663 --> 00:32:46,699
>> THIS IS WHY I'M SO GLAD
IT 

847
00:32:46,699 --> 00:32:50,502
WAS PICKED UP IN USA TODAY AND 

848
00:32:50,502 --> 00:32:51,170
NEW YORK TIMES TO GET THE 

849
00:32:51,170 --> 00:32:53,239
MESSAGE OUT NUMBER ONE.  I 

850
00:32:53,239 --> 00:32:55,708
THINK, THIS IS WHERE WE LEAN ON 

851
00:32:55,708 --> 00:33:01,947
DIVISIONS LIKE DCCPS AND I'M NOT

852
00:33:01,947 --> 00:33:04,650
SURE WHERE DR. CASTLE IS TO HELP

853
00:33:04,650 --> 00:33:06,619
US KNOW WHAT IS THE NEXT STUDY 

854
00:33:06,619 --> 00:33:07,686
THAT WE NEED TO DO TO REALLY 

855
00:33:07,686 --> 00:33:10,923
BRING SOME OF THESE THINGS INTO 

856
00:33:10,923 --> 00:33:13,259
PRACTICE TO PUT THIS IN THE 

857
00:33:13,259 --> 00:33:14,660
PUBLIC CONSCIOUSNESS TO HELP, 

858
00:33:14,660 --> 00:33:16,729
YOU KNOW, KNOW WHAT QUESTIONS 

859
00:33:16,729 --> 00:33:19,398
PEOPLE ARE EVEN ASKING ABOUT 

860
00:33:19,398 --> 00:33:21,467
THIS BEYOND -- IT'S ONE THING 

861
00:33:21,467 --> 00:33:23,335
FOR US AS SCIENTIST TO KNOW 

862
00:33:23,335 --> 00:33:24,870
THERE'S THIS REALLY BIG 

863
00:33:24,870 --> 00:33:26,105
DIFFERENCE AND ECONOMICALLY 

864
00:33:26,105 --> 00:33:28,007
THAT'S A BIG DEAL BUT WHEN IT 

865
00:33:28,007 --> 00:33:29,775
COMES TO AN INDIVIDUAL AND THEIR

866
00:33:29,775 --> 00:33:30,809
POCKETBOOK AND THEY'RE TRYING TO

867
00:33:30,809 --> 00:33:33,479
DECIDE WHAT SEEMS LIKE A VERY 

868
00:33:33,479 --> 00:33:35,581
EXPENSIVE SCREENING TEST AND IF 

869
00:33:35,581 --> 00:33:36,615
THAT'S A THING THEY SHOULD DO 

870
00:33:36,615 --> 00:33:40,085
TO -- IT'S HARD FOR THEM TO KNOW

871
00:33:40,085 --> 00:33:44,056
THAT THIS IS BENEFITTING AND SO 

872
00:33:44,056 --> 00:33:45,991
HOW DO WE COMMUNICATE THAT.  SO 

873
00:33:45,991 --> 00:33:50,062
THAT'S WORK THAT WE'RE DOING.  

874
00:33:50,062 --> 00:33:53,666
AND IF EITHER OF YOU HAVE 

875
00:33:53,666 --> 00:33:54,900
COMMENTS, PLEASE.

876
00:33:54,900 --> 00:33:56,869
>> THAT'S GREAT AND
THEY'RE 

877
00:33:56,869 --> 00:33:59,538
CONSIDERATIONS AND WH YOU TALK 

878
00:33:59,538 --> 00:34:01,273
ABOUT EARLY CANCERS AND 

879
00:34:01,273 --> 00:34:01,941
SCREENING GUIDELINES THAT'LL BE 

880
00:34:01,941 --> 00:34:04,343
ANOTHER IMPORTANT ASPECT SO WE 

881
00:34:04,343 --> 00:34:07,613
HAVE KNOW LOW AND I BELIEVE 

882
00:34:07,613 --> 00:34:08,047
SUSAN.

883
00:34:08,047 --> 00:34:09,949
>> YEAH, IT'S WONDERFUL TO
SEE 

884
00:34:09,949 --> 00:34:10,716
EVERYTHING THAT'S BEEN HAPPENING

885
00:34:10,716 --> 00:34:12,384
THIS SUMMER AND WHAT'S HAPPENING

886
00:34:12,384 --> 00:34:16,889
GOING FORWARD.  YESTERDAY IN THE

887
00:34:16,889 --> 00:34:19,091
THERAPEUTIC COMMITTEE MEETING WE

888
00:34:19,091 --> 00:34:20,292
HAD A CONVERSATION ABOUT PRIVATE

889
00:34:20,292 --> 00:34:21,627
PARTNERSHIPS AND I THINK TO YOUR

890
00:34:21,627 --> 00:34:22,661
QUESTION OF NUMBER ONE BUDGET 

891
00:34:22,661 --> 00:34:25,831
AND THEN THE PARTNERSHIPS AS 

892
00:34:25,831 --> 00:34:27,800
WELL.  I REALLY THINK 

893
00:34:27,800 --> 00:34:29,435
CONSIDERING THE AMOUNT OF 

894
00:34:29,435 --> 00:34:30,703
RESEARCH LED BY PRIVATE INDUSTRY

895
00:34:30,703 --> 00:34:32,972
RIGHT NOW THAT THIS IS AN 

896
00:34:32,972 --> 00:34:34,740
OPPORTUNITY WE'RE NOT GOING TO 

897
00:34:34,740 --> 00:34:37,443
GET EVERYTHING FROM WHAT WE SAID

898
00:34:37,443 --> 00:34:39,044
IN THE NEXT YEARS OUR BUDGET 

899
00:34:39,044 --> 00:34:40,713
WILL MATCH WHAT WE NEED AND IF 

900
00:34:40,713 --> 00:34:43,682
WE CAN INFLUENCE SOME OF THOSE 

901
00:34:43,682 --> 00:34:46,018
DOLLARS AND I THINK EVEN TO THE 

902
00:34:46,018 --> 00:34:48,120
SCREENING QUESTION YOU MENTIONED

903
00:34:48,120 --> 00:34:49,989
WE HAVE MULTIPLE HUGE COMPANIES 

904
00:34:49,989 --> 00:34:51,657
THAT HAVE SPUN OUT AROUND NEW 

905
00:34:51,657 --> 00:34:52,891
TECHNOLOGIES HOW CAN WE PARTNER 

906
00:34:52,891 --> 00:34:54,026
WITH THEM AND THEN THAT WILL 

907
00:34:54,026 --> 00:34:56,428
HELP FREE UP MORE MONEY THAT WE 

908
00:34:56,428 --> 00:34:58,731
COULD THEN INVEST IN JUNIOR 

909
00:34:58,731 --> 00:34:59,264
INVESTIGATORS BECAUSE WE 

910
00:34:59,264 --> 00:35:00,366
WOULDN'T NECESSARILY HAVE TO 

911
00:35:00,366 --> 00:35:01,934
FUND EVERY PIECE OF THE OTHER 

912
00:35:01,934 --> 00:35:06,171
RESEARCH THAT THE NCI FUNDS AND 

913
00:35:06,171 --> 00:35:07,573
SO IT'S NOT A SMALL LIFT BECAUSE

914
00:35:07,573 --> 00:35:12,244
THERE ARE SO MANY CONFLICTS I 

915
00:35:12,244 --> 00:35:15,247
THINK JULIE GRANT BROUGHT UP THE

916
00:35:15,247 --> 00:35:16,882
ISSUES OF FOR-PROFIT VERSUS 

917
00:35:16,882 --> 00:35:18,250
NONPROFIT.  THESE ARE NOT SMALL 

918
00:35:18,250 --> 00:35:19,385
ISSUES AND WILL REQUIRE SMALL 

919
00:35:19,385 --> 00:35:22,021
CHANGES IN THE WAY NCI DOES 

920
00:35:22,021 --> 00:35:23,489
THINGS TO MOVE MORE QUICKLY 

921
00:35:23,489 --> 00:35:24,857
WHICH IS WHAT THE INDUSTRY 

922
00:35:24,857 --> 00:35:25,991
SIGNIFICANTLY CARES MORE ABOUT 

923
00:35:25,991 --> 00:35:27,626
AND IF WE CAN DISRUPT THE WAY 

924
00:35:27,626 --> 00:35:29,595
THINGS ARE GOING AND DO IT IN A 

925
00:35:29,595 --> 00:35:31,063
NEW AND FASTER WAY I THINK THERE

926
00:35:31,063 --> 00:35:32,898
ARE BILLIONS OF DOLLARS THERE 

927
00:35:32,898 --> 00:35:36,835
THAT WE COULD LEVERAGE.

928
00:35:36,835 --> 00:35:38,670
>> I DON'T KNOW THAT I CAN
SAY 

929
00:35:38,670 --> 00:35:40,039
IT BETTER THAN THAT.  I 

930
00:35:40,039 --> 00:35:43,008
COMPLETELY AGREE.  BUT THIS IS 

931
00:35:43,008 --> 00:35:45,344
NOT AN US AND THEM GAME.  WE ARE

932
00:35:45,344 --> 00:35:48,814
ALL HERE FOR CANCER.  AND THAT'S

933
00:35:48,814 --> 00:35:50,482
WORKING TOGETHER ACROSS WHATEVER

934
00:35:50,482 --> 00:35:53,552
LINES ARE NECESSARY.  SO WE'RE 

935
00:35:53,552 --> 00:35:58,190
ALL IN SAY SUSAN .

936
00:35:58,190 --> 00:35:59,158
>> SUSAN.

937
00:35:59,158 --> 00:36:01,927
>> I WANTED TO GO BACK TO
THE 

938
00:36:01,927 --> 00:36:03,629
QUESTION YOU ASKED ABOUT THE 

939
00:36:03,629 --> 00:36:05,664
UTILITY OF FINDINGS.  AS SOON AS

940
00:36:05,664 --> 00:36:07,533
I SAW THOSE FINDINGS I THOUGHT 

941
00:36:07,533 --> 00:36:09,468
ABOUT HOW THEY REVERBERATES IN 

942
00:36:09,468 --> 00:36:11,170
OUR COMMUNITY.  MANY TIMES 

943
00:36:11,170 --> 00:36:14,807
STUDIES LIKE THIS GET PICKED UP 

944
00:36:14,807 --> 00:36:19,878
EVEN IN LOCAL NEWS OR OUR LOCAL 

945
00:36:19,878 --> 00:36:20,612
POLICYMA

946
00:36:20,612 --> 00:36:21,246
POLICYMAKERS.  ET CETERA, IT'S 

947
00:36:21,246 --> 00:36:22,681
REALLY A WAY THAT NCI HAS 

948
00:36:22,681 --> 00:36:24,216
SUPPORTED GENERATING EVIDENCE 

949
00:36:24,216 --> 00:36:28,787
THAT THEN INFORMS WHAT WE BRING 

950
00:36:28,787 --> 00:36:30,122
AS COMPELLING EVIDENCE TO INVEST

951
00:36:30,122 --> 00:36:34,426
IN SCREENING OR TO CHANGE SORT 

952
00:36:34,426 --> 00:36:38,897
OF THE SPEND OR TO ENCOURAGE 

953
00:36:38,897 --> 00:36:39,531
INDIVIDUALS TO REALLY PRIORITIZE

954
00:36:39,531 --> 00:36:41,066
IN A WAY THAT SAYS SHOW ME THE 

955
00:36:41,066 --> 00:36:44,870
DATA, SHOW ME THE NUMBERS AND 

956
00:36:44,870 --> 00:36:47,873
THIS IS SUCH A GREAT TOOL FOR US

957
00:36:47,873 --> 00:36:48,974
AT CANCER CENTERS TO BE ABLE TO 

958
00:36:48,974 --> 00:36:50,542
DO THAT TYPE OF WORK.  I WANTED 

959
00:36:50,542 --> 00:36:52,111
TO GIVE A SHOUT-OUT FOR THAT.

960
00:36:52,111 --> 00:36:53,345
>> AND IT WAS INTERESTING
IN 

961
00:36:53,345 --> 00:36:56,782
LOOKING AT THE BREAKDOWN OF THE 

962
00:36:56,782 --> 00:36:57,883
PROGRAMMATIC FUNDING.  CANCER 

963
00:36:57,883 --> 00:37:00,986
CONTROL WAS ABOUT HALF FOR 

964
00:37:00,986 --> 00:37:03,055
TREATMENT.  AND THERAPEUTICS.  I

965
00:37:03,055 --> 00:37:04,656
THINK THERE COULD BE SOME 

966
00:37:04,656 --> 00:37:06,091
DISCUSSIONS ABOUT SORT OF 

967
00:37:06,091 --> 00:37:08,494
SHIFTING THE BALANCE OF IT.  I 

968
00:37:08,494 --> 00:37:10,362
THINK WE HAVE ED HERE.

969
00:37:10,362 --> 00:37:11,864
>> YEAH, NEW MEMBER AND I
WILL 

970
00:37:11,864 --> 00:37:13,465
SAY THIS IS ME SITTING ON MY 

971
00:37:13,465 --> 00:37:15,501
HANDS.  IT TOOK ME A LONG TIME 

972
00:37:15,501 --> 00:37:16,535
TO ASK THIS FIRST QUESTION.  

973
00:37:16,535 --> 00:37:17,703
THANK YOU FOR THAT WONDERFUL 

974
00:37:17,703 --> 00:37:18,370
PRESENTATION.  IT'S INTERESTING 

975
00:37:18,370 --> 00:37:20,472
I THINK A LOT OF PEOPLE 

976
00:37:20,472 --> 00:37:22,407
INCLUDING MYSELF REALLY LIT UP 

977
00:37:22,407 --> 00:37:24,877
AT THAT SCREENING VERSUS 

978
00:37:24,877 --> 00:37:25,911
TREATMENT SLIDE IN PART BECAUSE 

979
00:37:25,911 --> 00:37:27,546
THERE WERE DOLLARS ATTACHED TO 

980
00:37:27,546 --> 00:37:28,647
IT AS FAR AS A RETURN ON 

981
00:37:28,647 --> 00:37:30,282
INVESTMENT IN THE SCREENING 

982
00:37:30,282 --> 00:37:32,084
ACTUALLY SAVED THE COUNTRY MONEY

983
00:37:32,084 --> 00:37:33,585
AND THERE'S BEEN MANY QUESTIONS 

984
00:37:33,585 --> 00:37:36,321
I THINK THAT HAVE BEEN STICKING 

985
00:37:36,321 --> 00:37:38,257
WITH THAT BECAUSE I FEEL THAT 

986
00:37:38,257 --> 00:37:40,959
ARGUMENT REVERBERATES A LOT AND 

987
00:37:40,959 --> 00:37:43,162
I KNOW U E-MAILED YOU ABOUT THIS

988
00:37:43,162 --> 00:37:44,596
BUT I REMEMBER HAVING A 

989
00:37:44,596 --> 00:37:45,964
CONVERSATION WITH A BUSINESS 

990
00:37:45,964 --> 00:37:47,533
COLLEAGUE WITH MINE AND 

991
00:37:47,533 --> 00:37:48,100
CONVINCING THEM THAT IT WAS 

992
00:37:48,100 --> 00:37:51,069
IMPORTANT THAT THE GOVERNMENT 

993
00:37:51,069 --> 00:37:52,304
INVEST IN SCIENCE BECAUSE 

994
00:37:52,304 --> 00:37:54,006
INDUSTRY WON'T DO IT, 

995
00:37:54,006 --> 00:37:55,574
PARTICULARLY FOR RARE CANCERS 

996
00:37:55,574 --> 00:37:57,843
BUT ONCE THE INVESTMENT IS MADE 

997
00:37:57,843 --> 00:37:59,411
IT MAKES WAY FOR INDUSTRY.  I 

998
00:37:59,411 --> 00:38:01,180
WANTED TO HEAR MORE AFTER YOUR 

999
00:38:01,180 --> 00:38:02,514
THOUGHTS ON HOW WE CAN CONTINUE 

1000
00:38:02,514 --> 00:38:03,982
TO GENERATE MORE DATA THAT COMES

1001
00:38:03,982 --> 00:38:05,484
INTO THESE PRESENTATIONS, THAT 

1002
00:38:05,484 --> 00:38:08,887
TALKS TO THAT PARTICULAR ROI AND

1003
00:38:08,887 --> 00:38:12,724
IF YOU LOOK AT EARLY STAGE OF 

1004
00:38:12,724 --> 00:38:13,992
INVESTIGATORS IS THERE A 

1005
00:38:13,992 --> 00:38:16,094
DIFFERENT ROI THAT WE HAVEN'T 

1006
00:38:16,094 --> 00:38:20,799
SEEN BEFORE THAN THOSE 

1007
00:38:20,799 --> 00:38:21,433
ESTABLISHED INVESTIGATORS THAT 

1008
00:38:21,433 --> 00:38:22,434
WE CONTINUE ON THAT ARGUMENT AND

1009
00:38:22,434 --> 00:38:25,904
DOUBLE DOWN ON THAT STRATEGY.

1010
00:38:25,904 --> 00:38:27,372
>> THAT'S A GREAT COMMENT
AND I 

1011
00:38:27,372 --> 00:38:28,106
WILL TAKE THAT IN A COUPLE 

1012
00:38:28,106 --> 00:38:29,641
DIFFERENT WAYS.  WHEN WE TALK 

1013
00:38:29,641 --> 00:38:31,677
ABOUT WHAT THE RETURN ON 

1014
00:38:31,677 --> 00:38:33,212
INVESTMENT IS I THINK THE PUBLIC

1015
00:38:33,212 --> 00:38:35,981
TENDS TO THINK ABOUT HEALTHY 

1016
00:38:35,981 --> 00:38:36,582
AMERICANS BUT IT'S REALLY SO 

1017
00:38:36,582 --> 00:38:38,617
MUCH MORE THE EFFECT ON THE 

1018
00:38:38,617 --> 00:38:39,518
ECONOMY REALLY CAN BE BROKEN 

1019
00:38:39,518 --> 00:38:40,819
DOWN IN LOTS OF DIFFERENT WAYS 

1020
00:38:40,819 --> 00:38:42,955
THE WORKFORCE IS A HUGE ONE AND 

1021
00:38:42,955 --> 00:38:44,790
HAVING A TALENTED SKILLED 

1022
00:38:44,790 --> 00:38:45,891
WORKFORCE THAT'S DOING 

1023
00:38:45,891 --> 00:38:46,792
DISCOVERIES AND MAKING 

1024
00:38:46,792 --> 00:38:53,031
DISCOVERIES THAT WILL IMPACT 

1025
00:38:53,031 --> 00:38:58,270
CANCER TODAY AND HEALTH 

1026
00:38:58,270 --> 00:38:58,804
TOMORROW.  THAT'S REALLY 

1027
00:38:58,804 --> 00:38:59,972
IMPORTANT AND HOW WE STIMULATE 

1028
00:38:59,972 --> 00:39:01,607
THE ECONOMY WITH NEW COMPANIES 

1029
00:39:01,607 --> 00:39:04,109
AND A LOT OF WHAT WE TALK ABOUT 

1030
00:39:04,109 --> 00:39:05,444
IS DE-RISKING.  AND WORK THAT WE

1031
00:39:05,444 --> 00:39:12,017
CAN DO TO TAKE A GREAT IDEA AND 

1032
00:39:12,017 --> 00:39:14,186
TAKE THE RISK AWAY TO BE TAKEN 

1033
00:39:14,186 --> 00:39:15,988
ON INTO THE PRIVATE SECTOR.  

1034
00:39:15,988 --> 00:39:20,425
THAT'S A HUGE ASSET OF THE 

1035
00:39:20,425 --> 00:39:21,727
FREDERICK WITH A LOT OF PROGRAMS

1036
00:39:21,727 --> 00:39:23,462
THAT WE HAVE.  WE CAN LOOK AT 

1037
00:39:23,462 --> 00:39:25,631
WAY TO DEMONSTRATE THAT A LITTLE

1038
00:39:25,631 --> 00:39:26,965
MORE EFFECTIVELY.

1039
00:39:26,965 --> 00:39:28,967
>> SO WE HAVE DOUG AND
THEN 

1040
00:39:28,967 --> 00:39:29,167
JULIE.

1041
00:39:29,167 --> 00:39:33,405
>> I SIMPLY WANTED TO
POINT OUT 

1042
00:39:33,405 --> 00:39:36,174
THAT THE SIS NET GROUP PUBLISHED

1043
00:39:36,174 --> 00:39:38,744
WHAT I THOUGHT WAS A VERY 

1044
00:39:38,744 --> 00:39:40,846
INTERESTING PAPER AND KATRINA 

1045
00:39:40,846 --> 00:39:47,286
GOD  GODDARD IS THE HEAD OF THAT

1046
00:39:47,286 --> 00:39:47,552
DIVISION. 

1047
00:39:47,552 --> 00:39:50,222
LOOKING AT HOW MANY LIVES COULD 

1048
00:39:50,222 --> 00:39:52,858
BE SAVED BY 10% FOR SEVERAL 

1049
00:39:52,858 --> 00:39:56,895
DIFFERENT CANCER TYPES IT'S 

1050
00:39:56,895 --> 00:40:01,199
REALLY IMPRESSIVE.  IT'S 

1051
00:40:01,199 --> 00:40:03,435
SOMETHING I CAN SEND AROUND THE 

1052
00:40:03,435 --> 00:40:06,471
REFERENCE IF YOU'RE INTERESTED.

1053
00:40:06,471 --> 00:40:07,072
>> JULIE.

1054
00:40:07,072 --> 00:40:09,608
>> THANK YOU FOR AN
INSPIRING 

1055
00:40:09,608 --> 00:40:11,743
CLEAR COMMUNICATION ABOUT YOUR 

1056
00:40:11,743 --> 00:40:12,611
PRIORITIES.  I WAS STRUCK AS YOU

1057
00:40:12,611 --> 00:40:16,214
SPEAK ABOUT WORKFORCE 

1058
00:40:16,214 --> 00:40:16,882
DEVELOPMENT.  IN PARTICULAR, A 

1059
00:40:16,882 --> 00:40:20,252
LOT OF THE EMPHASIS IS ON EARLY 

1060
00:40:20,252 --> 00:40:20,819
STAGE INVESTIGATORS.  I'M 

1061
00:40:20,819 --> 00:40:23,488
CURIOUS IF THAT IS THE PRIORITY.

1062
00:40:23,488 --> 00:40:24,956
AND AS YOU THINK ABOUT OTHER 

1063
00:40:24,956 --> 00:40:26,358
GAPS THAT WE HAVE IN OUR 

1064
00:40:26,358 --> 00:40:27,359
NATIONAL CANCER WORKFORCE, 

1065
00:40:27,359 --> 00:40:30,295
SHOULD WE BE PRIORITIZING THAT 

1066
00:40:30,295 --> 00:40:32,397
BECAUSE OF OBSERVATIONS YOU'VE 

1067
00:40:32,397 --> 00:40:34,032
MADE IN THE DATA THAT REALLY ARE

1068
00:40:34,032 --> 00:40:34,766
IMPORTANT FOR US TO UNDERSTAND 

1069
00:40:34,766 --> 00:40:37,269
THAT THAT IS THE PRIORITY?  I 

1070
00:40:37,269 --> 00:40:38,537
WOULD LIKE TO UNDERSTAND MORE SO

1071
00:40:38,537 --> 00:40:40,339
WE CAN HELP YOU WITH THOSE 

1072
00:40:40,339 --> 00:40:40,806
GOALS.

1073
00:40:40,806 --> 00:40:42,207
>> THANK YOU FOR THAT
QUESTION 

1074
00:40:42,207 --> 00:40:44,142
BECAUSE THAT IS A PRIORITY AND 

1075
00:40:44,142 --> 00:40:45,644
IMPORTANT TO ME BUT NOT THE ONLY

1076
00:40:45,644 --> 00:40:47,813
PRIORITY.  WHEN I TALK ABOUT 

1077
00:40:47,813 --> 00:40:49,247
WORKFORCE I REALLY MEAN 

1078
00:40:49,247 --> 00:40:51,483
DEVELOPING EVERYBODY.  THAT'S 

1079
00:40:51,483 --> 00:40:52,884
WHY I'VE BEEN SO HAPPY TO BE 

1080
00:40:52,884 --> 00:40:55,187
WORKING WITH PROGRAMS THAT ARE 

1081
00:40:55,187 --> 00:40:55,987
DEVELOPING HIGH SCHOOL AND 

1082
00:40:55,987 --> 00:40:57,989
UNDERGRADUATE STUDENT TO GET 

1083
00:40:57,989 --> 00:40:59,558
THEM INTERESTED IN STEM CAREERS.

1084
00:40:59,558 --> 00:41:01,827
THAT'S WHY WE'VE BEEN TALKING --

1085
00:41:01,827 --> 00:41:03,829
I AM REALLY INSPIRED BY THIS 

1086
00:41:03,829 --> 00:41:04,463
COMMUNITY COLLEGE PROGRAM AND, 

1087
00:41:04,463 --> 00:41:07,833
YOU KNOW, WAYS WE BOTH START 

1088
00:41:07,833 --> 00:41:09,000
WORKFORCE AROUND CLINICAL TRIAL 

1089
00:41:09,000 --> 00:41:10,702
OPERAT

1090
00:41:10,702 --> 00:41:12,504
OPERATIONS, THAT'S A REAL JOB 

1091
00:41:12,504 --> 00:41:16,274
FOR PEOPLE.  BUT I ALSO SEE 

1092
00:41:16,274 --> 00:41:21,446
WORKFORCE DEVELOPMENT IN WHO IS 

1093
00:41:21,446 --> 00:41:22,881
REALLY DELIVERING CARE.  I 

1094
00:41:22,881 --> 00:41:24,349
MENTIONED ONCOLOGISTS AND 

1095
00:41:24,349 --> 00:41:25,817
DEVELOPING THEIR CAPABILITIES TO

1096
00:41:25,817 --> 00:41:27,552
BE PART OF OUR RESEARCH ENGINE 

1097
00:41:27,552 --> 00:41:28,887
BECAUSE THEY'RE A HUGE PART OF 

1098
00:41:28,887 --> 00:41:30,989
OUR RESEARCH ENGINE BUT IT'S NOT

1099
00:41:30,989 --> 00:41:33,291
JUST ONCOLOGISTS, IT'S 

1100
00:41:33,291 --> 00:41:34,326
NURSE-PRACTITIONERS IN THE REALM

1101
00:41:34,326 --> 00:41:36,461
OF PREVENTION THIS IS PRIMARY 

1102
00:41:36,461 --> 00:41:38,530
CARE.  I MEAN, DEVELOPING THAT 

1103
00:41:38,530 --> 00:41:40,465
ASPECT OF OUR WORKFORCE ALSO 

1104
00:41:40,465 --> 00:41:42,033
SUPER IMPORTANT.  YOU KNOW, I 

1105
00:41:42,033 --> 00:41:44,202
HIGHLIGHT THE EARLY STAGE 

1106
00:41:44,202 --> 00:41:45,170
INVESTIGATORS AND WE'LL TALK 

1107
00:41:45,170 --> 00:41:46,905
LATER ABOUT POSTDOCS AND THOSE 

1108
00:41:46,905 --> 00:41:49,474
BECAUSE THAT IS ALSO SORT OF A 

1109
00:41:49,474 --> 00:41:51,877
CORE PART OF WHAT WE ARE AND 

1110
00:41:51,877 --> 00:41:55,080
WHAT WE NEED AND WHEN I LOOK AT 

1111
00:41:55,080 --> 00:41:56,882
NEEDLES THAT WE NEED TO MOVE, 

1112
00:41:56,882 --> 00:42:01,987
ONE IS THE AGE TO FIRST RO 1.  

1113
00:42:01,987 --> 00:42:12,464
AT, YOU KNOW SH, WE GET THEM IN 

1114
00:42:12,464 --> 00:42:14,900
THE FUNDING POOL EARLIER.  

1115
00:42:14,900 --> 00:42:16,868
THAT'S ONE REASON TO FUND EARLY 

1116
00:42:16,868 --> 00:42:18,537
STAGE INVESTIGATORS.  SO TO ME 

1117
00:42:18,537 --> 00:42:22,908
IT'S ABOUT KEEPING OUR PIPELINE 

1118
00:42:22,908 --> 00:42:33,185
ROBUST.  MAY I.

1119
00:42:37,355 --> 00:42:39,024
>> IF YOU WANT TO EXTEND
WE HAVE

1120
00:42:39,024 --> 00:42:39,424
A FEW MINUTES.

1121
00:42:39,424 --> 00:42:42,794
>> I THINK WHAT YOU SAID
IS 

1122
00:42:42,794 --> 00:42:45,964
REALLY IMPORTANT.  I WAS STRUCK 

1123
00:42:45,964 --> 00:42:50,402
SUICIDE  BY THE CANCER FUNDING 

1124
00:42:50,402 --> 00:42:51,002
GAP. 

1125
00:42:51,002 --> 00:42:53,405
I THINK AS WE THINK ABOUT OUR 

1126
00:42:53,405 --> 00:42:54,606
COMMUNICATION PLAN FOR THE NCI 

1127
00:42:54,606 --> 00:42:56,908
AND HOW WE CAN BRING OTHER TO 

1128
00:42:56,908 --> 00:42:58,944
THE TABLE FOR THOSE SPECIFIC 

1129
00:42:58,944 --> 00:43:00,779
OCCUPATIONAL ROLES THAT ARE 

1130
00:43:00,779 --> 00:43:03,181
COMPLEMENTARY TO THEIR MISSION 

1131
00:43:03,181 --> 00:43:04,883
WHAT, YOU JUST DESCRIBED SEEMS 

1132
00:43:04,883 --> 00:43:06,418
REALLY COMPELLING TO ME.  WHEN I

1133
00:43:06,418 --> 00:43:07,886
THINK ABOUT THE JOBS THAT ARE 

1134
00:43:07,886 --> 00:43:09,621
TIED TO THE IMPLEMENTATION OF 

1135
00:43:09,621 --> 00:43:11,823
CANCER AND NURSES OR IN MY CASE,

1136
00:43:11,823 --> 00:43:16,061
AS I'M TIED TO THE BIOTECH 

1137
00:43:16,061 --> 00:43:18,196
INDUSTRY, THE PHARMACEUTICAL 

1138
00:43:18,196 --> 00:43:20,699
INDUSTRY IT'S CLINICAL TRIAL 

1139
00:43:20,699 --> 00:43:22,934
COORDINATORS, MANAGERS, 

1140
00:43:22,934 --> 00:43:27,172
INDIVIDUAL WHO IS -- INDIVIDUALS

1141
00:43:27,172 --> 00:43:28,473
WHO ARE TRAINED. 

1142
00:43:28,473 --> 00:43:30,108
I WOULD REALLY LOVE TO CONTINUE 

1143
00:43:30,108 --> 00:43:31,510
TO ENGAGE IN THE CONVERSATION.  

1144
00:43:31,510 --> 00:43:34,479
HOW DO WE BRING OTHER TO HELP 

1145
00:43:34,479 --> 00:43:36,014
SUPPLEMENT FUNDING WHERE WE SEE 

1146
00:43:36,014 --> 00:43:38,450
GAPS IN OUR WORKFORCE AND HOW DO

1147
00:43:38,450 --> 00:43:40,185
WE BRING THEM TOGETHER AND THANK

1148
00:43:40,185 --> 00:43:41,353
YOU FOR OUTLINING THE ADDITIONAL

1149
00:43:41,353 --> 00:43:43,488
JOBS THAT YOU THINK WE NEED TO 

1150
00:43:43,488 --> 00:43:45,657
INVEST IN.  IT'S VERY HELPFUL 

1151
00:43:45,657 --> 00:43:46,024
FOR ME.

1152
00:43:46,024 --> 00:43:49,060
>> DR. CLARK, PLEASE.

1153
00:43:49,060 --> 00:43:50,896
>> HI, I'M DR. CLARK, ALSO
NEW 

1154
00:43:50,896 --> 00:43:53,064
TO THE BOARD SO THANK YOU SO 

1155
00:43:53,064 --> 00:43:56,234
MUCH.  I'M VERY PLEASED TO SEE 

1156
00:43:56,234 --> 00:43:58,970
THE EFFORTS ON DEVELOPING AND 

1157
00:43:58,970 --> 00:44:02,173
MAINTAINING A WORKFORCE THAT'S 

1158
00:44:02,173 --> 00:44:04,509
ROBUST AND DIVERSE.  I THINK 

1159
00:44:04,509 --> 00:44:05,877
THIS HAS BEEN UNDERRECOGNIZED 

1160
00:44:05,877 --> 00:44:10,181
AND UNDERFOCUSED ON FOR A LONG 

1161
00:44:10,181 --> 00:44:12,250
TIME.  AS WE TALK ABOUT 

1162
00:44:12,250 --> 00:44:13,685
PRODUCING INNOVATIVE TREATMENTS 

1163
00:44:13,685 --> 00:44:15,520
FOR CANCER WE HAVE TO UNDERSTAND

1164
00:44:15,520 --> 00:44:16,187
THAT THESE TREATMENTS OFTEN 

1165
00:44:16,187 --> 00:44:18,657
WIDEN THE DISPARITIES FOR PEOPLE

1166
00:44:18,657 --> 00:44:20,892
WHO DON'T GET ACCESS TO THESE 

1167
00:44:20,892 --> 00:44:23,595
TREATMENTS.  AND WE'VE SEEN THAT

1168
00:44:23,595 --> 00:44:24,896
CONCORDANCE AND CARE RACIALLY 

1169
00:44:24,896 --> 00:44:27,232
FROM GENDER STANDPOINT AND 

1170
00:44:27,232 --> 00:44:28,767
ESPECIALLY FROM FIRST LANGUAGE 

1171
00:44:28,767 --> 00:44:30,702
ACTUALLY IMPACTS A PATIENT'S 

1172
00:44:30,702 --> 00:44:32,504
ABILITY TO EITHER GET THEIR 

1173
00:44:32,504 --> 00:44:35,006
CANCER TREATMENT OR TO ACTUALLY 

1174
00:44:35,006 --> 00:44:37,542
UNDERGO CANCER SCREENING SO 

1175
00:44:37,542 --> 00:44:39,311
UNTIL WE FOCUS ON MAKING SURE WE

1176
00:44:39,311 --> 00:44:41,112
HAVE A WORKFORCE THAT REPRESENTS

1177
00:44:41,112 --> 00:44:43,548
OUR PATIENTS WE'LL CONSISTENTLY 

1178
00:44:43,548 --> 00:44:45,116
BE CHASING OUR TAILS.  SO I'M 

1179
00:44:45,116 --> 00:44:47,218
REALLY EXCITED TO ACTUALLY SEE 

1180
00:44:47,218 --> 00:44:48,587
THAT THE PRESIDENTIAL CANCER 

1181
00:44:48,587 --> 00:44:50,922
PANEL WILL BE TALKING ABOUT 

1182
00:44:50,922 --> 00:44:52,424
THIS, I'LL BE PARTICIPATING BUT 

1183
00:44:52,424 --> 00:44:53,058
IT'LL BE REALLY IMPORTANT FOR 

1184
00:44:53,058 --> 00:44:55,060
EVERYBODY IN THE ROOM TO 

1185
00:44:55,060 --> 00:44:56,261
UNDERSTAND EXACTLY WHY THIS IS 

1186
00:44:56,261 --> 00:44:59,030
SO CRITICAL AND FOR THE NCI TO 

1187
00:44:59,030 --> 00:45:00,599
RECOGNIZE THAT THIS IS AS 

1188
00:45:00,599 --> 00:45:02,601
IMPORTANT AS A PILLAR AS A 

1189
00:45:02,601 --> 00:45:04,436
DEVELOPMENT OF INNOVATIVE 

1190
00:45:04,436 --> 00:45:04,703
TREATMENT.

1191
00:45:04,703 --> 00:45:08,873
>> AGREED.  IT'S
LONG-STANDING 

1192
00:45:08,873 --> 00:45:14,813
ISSUE.  I REMEMBER THE EARLY 

1193
00:45:14,813 --> 00:45:16,881
PAPER ON LYMPHOMA SHOWING THE 

1194
00:45:16,881 --> 00:45:18,483
HUGE DISPARITY BY RACE AND BY 

1195
00:45:18,483 --> 00:45:19,551
INSURANCE STATUS AND THE LAST 

1196
00:45:19,551 --> 00:45:22,387
QUESTION WILL GO TO FRED.

1197
00:45:22,387 --> 00:45:30,962
>> THANKS.

1198
00:45:30,962 --> 00:45:35,133
>> HI, IT'S VERY
COMPELLING THE 

1199
00:45:35,133 --> 00:45:37,235
NUMBER OF SCREENING VERSUS 

1200
00:45:37,235 --> 00:45:40,238
TREATMENT.  IN JUNE WE HAD AN 

1201
00:45:40,238 --> 00:45:40,872
EXCELLENT PRESENTATION FROM 

1202
00:45:40,872 --> 00:45:43,708
DR. CASTLE ON LIQUID BIOPSIES 

1203
00:45:43,708 --> 00:45:45,744
AND WHAT INDUSTRIES ARE LOBBYING

1204
00:45:45,744 --> 00:45:47,212
AND MOVING MUCH FASTER THAN THE 

1205
00:45:47,212 --> 00:45:49,848
SCIENCE AND I'M WONDERING, YOU 

1206
00:45:49,848 --> 00:45:53,685
KNOW, HOW DO WE SQUARE THAT?  

1207
00:45:53,685 --> 00:45:55,620
ESPECIALLY ON CLINICAL UTILITY 

1208
00:45:55,620 --> 00:45:57,489
OF THOSE SCREENINGS.  YOU KNOW, 

1209
00:45:57,489 --> 00:45:59,724
HOW WE BALANCE THE OPTIMISM WITH

1210
00:45:59,724 --> 00:46:03,061
THE SCIENCE.  HOW DOES NIH -- 

1211
00:46:03,061 --> 00:46:05,063
NCI CATCH UP.  ESPECIALLY WITH 

1212
00:46:05,063 --> 00:46:05,363
THE SCIENCE.

1213
00:46:05,363 --> 00:46:09,000
>> YEAH, I THINK THAT'S --
IT'S 

1214
00:46:09,000 --> 00:46:16,541
A REALLY IMPORTANT AND THERE ARE

1215
00:46:16,541 --> 00:46:17,308
TIME WHEN IS THE CLINICAL 

1216
00:46:17,308 --> 00:46:19,878
TESTING THE AHEAD OF THE 

1217
00:46:19,878 --> 00:46:20,879
SCIENCE.  THAT'S OUR JOB IS TO 

1218
00:46:20,879 --> 00:46:22,547
BE ON TOP OF THOSE THINGS AND TO

1219
00:46:22,547 --> 00:46:24,883
BE DESIGNING STUDIES LIKE WE ARE

1220
00:46:24,883 --> 00:46:25,784
TO GET THE INFORMATION THAT WE 

1221
00:46:25,784 --> 00:46:30,388
NEED TO MAKE SOUND DECISIONS.

1222
00:46:30,388 --> 00:46:32,891
>> WELL THANK YOU SO MUCH,
KIM, 

1223
00:46:32,891 --> 00:46:36,494
FOR REALLY AMAZING DIRECTOR'S 

1224
00:46:36,494 --> 00:46:37,862
REPORT.  I THANK YOU ALSO SENT 

1225
00:46:37,862 --> 00:46:39,597
US AWAY WITH SOME HOMEWORK.  A 

1226
00:46:39,597 --> 00:46:40,865
FEW QUESTIONS THAT YOU'D LIKE TO

1227
00:46:40,865 --> 00:46:43,068
GET SOME FEEDBACK FROM THE BOARD

1228
00:46:43,068 --> 00:46:44,335
ON IT WOULD BE GREAT IF WE COULD

1229
00:46:44,335 --> 00:46:45,437
SHARE THOSE.  SOME KIND OF WAY 

1230
00:46:45,437 --> 00:46:48,540
TO THE BOARD SO WE CAN ALL THINK

1231
00:46:48,540 --> 00:46:50,208
ABOUT THEM PERHAPS AND PROVIDE 

1232
00:46:50,208 --> 00:46:51,276
SOME COMMENTS AND FEEDBACK TO 

1233
00:46:51,276 --> 00:46:52,877
YOU.  THANK YOU.  OKAY, GREAT, 

1234
00:46:52,877 --> 00:46:56,881
SO NEXT IS THE BUDGET UPDATE 

1235
00:46:56,881 --> 00:47:00,285
FROM DR. DOUGLAS LOW WE AND 

1236
00:47:00,285 --> 00:47:07,058
MR. WESTON RICKS WHO IS THE NCI 

1237
00:47:07,058 --> 00:47:08,893
BUDGET OFFICER.  DOUG AND 

1238
00:47:08,893 --> 00:47:09,127
WESTON.

1239
00:47:09,127 --> 00:47:11,062
>> THANK YOU FOR INVITING
US TO 

1240
00:47:11,062 --> 00:47:12,797
COME AND VISIT.  I'M GLAD TO BE 

1241
00:47:12,797 --> 00:47:14,265
ABLE TO PRESENT WITH DOUG.  A 

1242
00:47:14,265 --> 00:47:15,567
LOT OF PEOPLE WORK TO HELP US 

1243
00:47:15,567 --> 00:47:16,868
MOVE THE BUDGET FORWARD. 

1244
00:47:16,868 --> 00:47:18,670
AND MAKE A LOT OF STRATEGIC 

1245
00:47:18,670 --> 00:47:21,139
DECISIONS ACROSS THE INSTITUTE. 

1246
00:47:21,139 --> 00:47:22,741
PARTICULARLY FOR THIS 

1247
00:47:22,741 --> 00:47:24,909
PRESENTATION WE'D LIKE TO THANK 

1248
00:47:24,909 --> 00:47:28,880
TENNILLE AND CHRISTINE WHO HAVE 

1249
00:47:28,880 --> 00:47:32,884
HELPED UPDATE SOME OF THESE 

1250
00:47:32,884 --> 00:47:42,127
SLIDES.  NOW ONE OF THE THINGS I

1251
00:47:42,127 --> 00:47:43,962
HOPE YOU WILL TAKE A WAY IS TO 

1252
00:47:43,962 --> 00:47:46,798
HAVE A PERSPECTIVE OF THE BUDGET

1253
00:47:46,798 --> 00:47:53,404
OVER TIME.  MY CHILDREN ARE 

1254
00:47:53,404 --> 00:47:55,907
REALLY INTO BAKING.  OVER THE 

1255
00:47:55,907 --> 00:47:58,443
LAST YEAR ONE OF MY SONS DECIDED

1256
00:47:58,443 --> 00:47:59,844
HE WANTED TO MAKE COOKIES AND 

1257
00:47:59,844 --> 00:48:01,679
SELL THEM AT THE HIGH SCHOOL.  

1258
00:48:01,679 --> 00:48:03,214
TWICE A WEEK HE WOULD STAY UP 

1259
00:48:03,214 --> 00:48:04,883
LATE INTO THE NIGHT BEYOND MY 

1260
00:48:04,883 --> 00:48:07,051
OWN BEDTIME AND I'D WAKE UP AND 

1261
00:48:07,051 --> 00:48:08,887
HE'D HAVE A BACKPACK FULL OF 

1262
00:48:08,887 --> 00:48:12,290
COOKIES AND WOULD GO AND SELL 

1263
00:48:12,290 --> 00:48:14,826
THEM AND WHILE I REALLY 

1264
00:48:14,826 --> 00:48:15,760
RESPECTED HIS ENTREPRENEURIAL 

1265
00:48:15,760 --> 00:48:16,895
ENDEAVOR HE AND I HAD A 

1266
00:48:16,895 --> 00:48:18,797
CONVERSATION ABOUT WHAT IT COSTS

1267
00:48:18,797 --> 00:48:23,067
TO CREATE THOSE COOKIES AND WHAT

1268
00:48:23,067 --> 00:48:24,869
MY CONTRIBUTION WAS AND SO HE 

1269
00:48:24,869 --> 00:48:26,337
EVENTUALLY GOT ENOUGH OF HIS OWN

1270
00:48:26,337 --> 00:48:28,873
MONEY THAT HE WAS TABLE REINVEST

1271
00:48:28,873 --> 00:48:31,276
INTO HIS ENDEAVOR AND BUY HIS 

1272
00:48:31,276 --> 00:48:32,877
OWN INGREDIENTS AND HE HAD HIS 

1273
00:48:32,877 --> 00:48:34,412
OWN GARBAGE LOOKING BOX OF 

1274
00:48:34,412 --> 00:48:36,548
INGREDIENTS THAT SAT ON THE 

1275
00:48:36,548 --> 00:48:38,283
COUNTER FOR QUITE SOME TIME AND 

1276
00:48:38,283 --> 00:48:40,885
I REALLY APPRECIATED IT BECAUSE 

1277
00:48:40,885 --> 00:48:43,054
I WOULD WATCH HIM, HE WOULD BUY 

1278
00:48:43,054 --> 00:48:44,889
SOME OF HIS INGREDIENTS.  EVERY 

1279
00:48:44,889 --> 00:48:46,958
NOW AND THEN WOULD NEED SOME 

1280
00:48:46,958 --> 00:48:48,893
CHOCOLATE CHIPS AND I WOULD GET 

1281
00:48:48,893 --> 00:48:50,361
A CASH OUT PURCHASE FROM MYSELF 

1282
00:48:50,361 --> 00:48:54,165
AND ONE OF THE THINGS THAT WE 

1283
00:48:54,165 --> 00:48:56,000
DIDN'T ALWAYS... I DID NOT 

1284
00:48:56,000 --> 00:48:58,703
ADDRESS WITH HIM IS IT'S NOT 

1285
00:48:58,703 --> 00:49:00,271
JUST ABOUT THE DOUGH THERE ARE A

1286
00:49:00,271 --> 00:49:02,307
LOT OF OTHER THINGS I WAS 

1287
00:49:02,307 --> 00:49:04,342
PROVIDING TO HIM THAT HE MAYBE 

1288
00:49:04,342 --> 00:49:06,144
DIDN'T APPRECIATE.  IF YOU'RE 

1289
00:49:06,144 --> 00:49:07,345
LOOKING AT THIS PIE RIGHT HERE 

1290
00:49:07,345 --> 00:49:08,780
BECAUSE WE IN BUDGET LIKE TO 

1291
00:49:08,780 --> 00:49:11,182
TALK ABOUT PIES A LOT WE'LL SHOW

1292
00:49:11,182 --> 00:49:13,718
YOU A PIE OR TWO ONE OF THE 

1293
00:49:13,718 --> 00:49:16,187
THINGS IS YOU CAN SEE THIS PIE 

1294
00:49:16,187 --> 00:49:19,791
IS IN A PIE BOWL OR A PIE PAN 

1295
00:49:19,791 --> 00:49:20,892
AND IT'S ALSO SITTING ON THE 

1296
00:49:20,892 --> 00:49:22,327
STOVE THAT HAPPENS TO BE FUELLED

1297
00:49:22,327 --> 00:49:25,196
BY GAS THAT I PAY FOR.  I ALSO 

1298
00:49:25,196 --> 00:49:28,299
BOUGHT THAT STOVE.  AND IT 

1299
00:49:28,299 --> 00:49:29,868
HAPPENS TO BE IN A HOUSE I MAKE 

1300
00:49:29,868 --> 00:49:32,337
PAYMENTS ON ROUTINELY JUST TO 

1301
00:49:32,337 --> 00:49:34,939
KEEP US IN THAT SORT OF 

1302
00:49:34,939 --> 00:49:35,974
SITUATION.  SO I WANT YOU TO 

1303
00:49:35,974 --> 00:49:37,976
KEEP THAT IN MIND AS WE GO 

1304
00:49:37,976 --> 00:49:40,245
FORWARD.  IT'S NOT JUST ABOUT 

1305
00:49:40,245 --> 00:49:41,813
THE DOUGH HERE BUT WHAT GOES 

1306
00:49:41,813 --> 00:49:44,315
INTO THE NCI PIE?  OVER THE LAST

1307
00:49:44,315 --> 00:49:46,117
SEVERAL YEARS AND I WILL BE 

1308
00:49:46,117 --> 00:49:47,685
PUTTING THIS IN PERSPECTIVE OVER

1309
00:49:47,685 --> 00:49:48,786
THE LAST TWO DECADES 

1310
00:49:48,786 --> 00:49:50,555
ESSENTIALLY.  THERE ARE A LOT OF

1311
00:49:50,555 --> 00:49:53,157
THINGS THAT THE NATIONAL CANCER 

1312
00:49:53,157 --> 00:49:56,694
INSTITUTE LEADERSHIP, OUR 

1313
00:49:56,694 --> 00:49:59,130
COMMUNITY STAKEHOLDERS, OUR 

1314
00:49:59,130 --> 00:50:01,432
RESEARCH STAKEHOLDERS THINK 

1315
00:50:01,432 --> 00:50:03,134
ABOUT WHAT THEY WANT TO PUT INTO

1316
00:50:03,134 --> 00:50:04,802
THE PIE AND THIS IS A SHORT LIST

1317
00:50:04,802 --> 00:50:06,771
OF THEM.  THERE ARE PLENTY OF 

1318
00:50:06,771 --> 00:50:07,772
OTHERS I JUST DIDN'T WANT TO 

1319
00:50:07,772 --> 00:50:09,340
BORE YOU WITH THE SLIDES SHOWING

1320
00:50:09,340 --> 00:50:10,675
YOU EVERY SINGLE THING THAT WE 

1321
00:50:10,675 --> 00:50:13,578
HAVE TO PARTICIPATE IN OR WE 

1322
00:50:13,578 --> 00:50:14,979
SUPPORT OR THAT HELPS SUPPORT 

1323
00:50:14,979 --> 00:50:17,548
THIS GOING FORWARD BUT YOU CAN 

1324
00:50:17,548 --> 00:50:24,889
SEE HERE THERE'S A SCORE -- 

1325
00:50:24,889 --> 00:50:28,159
SPORE PROGRAM.  THERE'S THE 

1326
00:50:28,159 --> 00:50:30,128
CLINICAL RESEARCH HOSPITAL IN MY

1327
00:50:30,128 --> 00:50:31,429
OPINION.  WE SPEND A LOT OF 

1328
00:50:31,429 --> 00:50:33,464
MONEY, AND ALSO THE SMALL 

1329
00:50:33,464 --> 00:50:35,066
BUSINESS LINE RIGHT HERE.  

1330
00:50:35,066 --> 00:50:38,069
BECAUSE OF THE NATURE OF US AS A

1331
00:50:38,069 --> 00:50:40,371
FEDERAL AGENCY.  WE'RE REQUIRED 

1332
00:50:40,371 --> 00:50:42,273
TO FUND SOME ASPECTS OF OUR 

1333
00:50:42,273 --> 00:50:43,875
BUDGET TOWARD SMALL BUSINESS, 

1334
00:50:43,875 --> 00:50:46,244
THESE ARE THINGS THAT SOME OF 

1335
00:50:46,244 --> 00:50:47,445
OUR INSIDER CONTROL, SOME OF 

1336
00:50:47,445 --> 00:50:49,380
THEM ARE OUTSIDE OF OUR CONTROL 

1337
00:50:49,380 --> 00:50:50,581
BUT THEY ALL CONTRIBUTE TO THE 

1338
00:50:50,581 --> 00:50:51,282
RECIPE. 

1339
00:50:51,282 --> 00:50:53,084
AND ONE OF THE OTHER THINGS 

1340
00:50:53,084 --> 00:50:54,319
SOMETIMES PEOPLE DON'T 

1341
00:50:54,319 --> 00:50:56,421
APPRECIATE ABOUT WHEN YOU ARE 

1342
00:50:56,421 --> 00:50:58,890
CREATING A RECIPE IS THAT 

1343
00:50:58,890 --> 00:51:00,892
DIFFERENT THINGS TAKE MORE TIME 

1344
00:51:00,892 --> 00:51:02,460
THAN OTHERS AND SO DEPENDING ON 

1345
00:51:02,460 --> 00:51:04,329
WHAT YOU'RE TRYING TO BAKE OUT 

1346
00:51:04,329 --> 00:51:06,664
THAT TIME IS GOING TO TAKE 

1347
00:51:06,664 --> 00:51:10,068
AWHILE.  MY WIFE HAS LATELY BEEN

1348
00:51:10,068 --> 00:51:12,303
WORKING WITH SOUR DOUGH STARTS. 

1349
00:51:12,303 --> 00:51:14,305
YOU HAVE TO GROW IT, PROOF IT, 

1350
00:51:14,305 --> 00:51:15,406
COOK IT AND THEN YOU HAVE TO 

1351
00:51:15,406 --> 00:51:17,909
ACTUALLY EAT IT WHICH DEPENDING 

1352
00:51:17,909 --> 00:51:19,043
ON YOUR PERSPECTIVE ON SOUR 

1353
00:51:19,043 --> 00:51:23,214
DOUGH MIGHT TAKE LONGER THAN SHE

1354
00:51:23,214 --> 00:51:31,856
EXPECTS.  AS YOU'RE DOING THESE 

1355
00:51:31,856 --> 00:51:34,592
THINGS THERE ARE ASPECTS OF LIFE

1356
00:51:34,592 --> 00:51:36,761
THAT NIBBLE AWAY AT YOUR DOUGH 

1357
00:51:36,761 --> 00:51:38,196
AND I WILL GIVE YOU AN EXAMPLE 

1358
00:51:38,196 --> 00:51:40,898
HERE.  THE BIOMEDICAL RESEARCH 

1359
00:51:40,898 --> 00:51:42,567
AND DEVELOPMENT PRICE INDEX, 

1360
00:51:42,567 --> 00:51:44,569
THIS -- WE'VE TALKED ABOUT 

1361
00:51:44,569 --> 00:51:46,804
BEFORE BUT THIS IS ESSENTIALLY 

1362
00:51:46,804 --> 00:51:48,673
AN INFLATIONARY PRICE INDEX 

1363
00:51:48,673 --> 00:51:50,775
ASSOCIATED WITH MEDICAL 

1364
00:51:50,775 --> 00:51:51,909
RESEARCH.  IT IS ESTABLISHED BY 

1365
00:51:51,909 --> 00:51:53,211
AND RUN BY THE NATIONAL 

1366
00:51:53,211 --> 00:51:54,879
INSTITUTES OF HEALTH.  THEY 

1367
00:51:54,879 --> 00:51:56,581
RELEASE IT EVERY YEAR AND THEY 

1368
00:51:56,581 --> 00:51:58,983
LET YOU KNOW WHAT THEY THINK THE

1369
00:51:58,983 --> 00:52:00,918
INFLATIONARY IMPACT OF THE COST 

1370
00:52:00,918 --> 00:52:05,089
ASSOCIATED WITH BIOMEDICAL 

1371
00:52:05,089 --> 00:52:06,124
RESEARCH EACH YEAR. 

1372
00:52:06,124 --> 00:52:08,192
OVER TIME THAT CAN HAVE A 

1373
00:52:08,192 --> 00:52:09,994
SIGNIFICANT IMPACT.  YOU CAN SEE

1374
00:52:09,994 --> 00:52:13,998
IN 2003, THE BUYING POWER AND 

1375
00:52:13,998 --> 00:52:16,501
THE BUDGET AND NOMINAL TERMS ARE

1376
00:52:16,501 --> 00:52:16,934
EXACTLY THE SAME.  

1377
00:52:16,934 --> 00:52:20,204
BUT AS YOU GO FORWARD, DEPENDING

1378
00:52:20,204 --> 00:52:21,672
ON HOW MUCH MONEY IS ADDED TO 

1379
00:52:21,672 --> 00:52:24,208
THE BUDGET AND THAT INFLATIONARY

1380
00:52:24,208 --> 00:52:27,478
PRICE INDEX, IT GETS OUT OF SYNC

1381
00:52:27,478 --> 00:52:29,213
AND IN 2013 YOU CAN SEE THERE'S 

1382
00:52:29,213 --> 00:52:36,888
A MAJOR, MAJOR DIFFERENCE.  AND 

1383
00:52:36,888 --> 00:52:38,823
THEN YOU MOVE FORWARD AND YOU 

1384
00:52:38,823 --> 00:52:39,924
SEE WE HAVE NOT REACHED PARITY 

1385
00:52:39,924 --> 00:52:46,564
WITH WHERE WE WERE IN 2003.  IN 

1386
00:52:46,564 --> 00:52:50,802
FACT IN 2024 WE'RE 15% LESS 

1387
00:52:50,802 --> 00:52:53,738
BUYER POWER.  THOSE NUMBERS 

1388
00:52:53,738 --> 00:52:56,541
BECOME VERY, VERY REAL YEAR OVER

1389
00:52:56,541 --> 00:52:57,642
YEAR.  OKAY?  ANOTHER ASPECT 

1390
00:52:57,642 --> 00:53:00,478
THAT CHEWS AWAY AT OUR BUDGET 

1391
00:53:00,478 --> 00:53:03,414
AND STICKS THE FINGER IN THE 

1392
00:53:03,414 --> 00:53:04,582
DOUGH A LITTLE BIT IS THE 

1393
00:53:04,582 --> 00:53:06,217
COMPETING NEEDS ACROSS THE 

1394
00:53:06,217 --> 00:53:06,851
FEDERAL GOVERNMENT.  OVER THE 

1395
00:53:06,851 --> 00:53:08,086
LAST TWO YEARS YOU PROBABLY HAD 

1396
00:53:08,086 --> 00:53:09,287
A LOT OF INFORMATION CERTAINLY 

1397
00:53:09,287 --> 00:53:11,089
READ IN THE NEWS AND I THINK MK 

1398
00:53:11,089 --> 00:53:14,192
WILL TOUCH ON THIS A LOT MORE.  

1399
00:53:14,192 --> 00:53:15,526
IS THERE ARE A LOT OF COMPETING 

1400
00:53:15,526 --> 00:53:17,261
NEEDS ACROSS THE FEDERAL 

1401
00:53:17,261 --> 00:53:20,865
GOVERNMENT.  WE ARE NOT THE 

1402
00:53:20,865 --> 00:53:21,399
UNITED STATES OF CANCER 

1403
00:53:21,399 --> 00:53:24,869
RESEARCH.  WE ARE THE UNITED 

1404
00:53:24,869 --> 00:53:27,171
STATES OF AMERICA WITH A LOT OF 

1405
00:53:27,171 --> 00:53:28,806
SECURITY NEEDS, INFRASTRUCTURE 

1406
00:53:28,806 --> 00:53:31,409
NEEDS ACROSS THE ENTIRE EXPANSE 

1407
00:53:31,409 --> 00:53:32,443
OF GLOBAL REQUIREMENTS BECAUSE 

1408
00:53:32,443 --> 00:53:34,445
OF THAT A LOT OF DECISIONS THAT 

1409
00:53:34,445 --> 00:53:37,582
GOES INTO WHAT MAKES OR IMPACTS 

1410
00:53:37,582 --> 00:53:39,584
THE LEDGER OF THE NATIONAL 

1411
00:53:39,584 --> 00:53:42,520
CANCER INSTITUTE ARE IMPACTED BY

1412
00:53:42,520 --> 00:53:44,889
THOSE DECISIONS THAT COMPLEMENTS

1413
00:53:44,889 --> 00:53:45,957
THOSE PRIORITIES. 

1414
00:53:45,957 --> 00:53:48,826
HOW IS THAT IMPACTED US MOST 

1415
00:53:48,826 --> 00:53:49,727
RECENTLY?  YOU MAY HAVE SEEN 

1416
00:53:49,727 --> 00:53:53,197
THIS BEFORE BUT YOU CAN SEE HERE

1417
00:53:53,197 --> 00:53:58,503
IN PURPLE IS OUR TOTAL.  THERE'S

1418
00:53:58,503 --> 00:54:01,105
THE MOON SHOT AND THEN THERE'S 

1419
00:54:01,105 --> 00:54:07,111
THE BASE BUDGET.  AND FROM 

1420
00:54:07,111 --> 00:54:09,714
2023-24, THE CANCER MOON SHOT 

1421
00:54:09,714 --> 00:54:11,115
ENDED, THE ORIGINAL CANCER MOON 

1422
00:54:11,115 --> 00:54:13,417
SHOT STOPPED GETTING NEW MONEY 

1423
00:54:13,417 --> 00:54:14,385
AND OUR REGULAR BUDGET WAS 

1424
00:54:14,385 --> 00:54:16,087
INCREASED A LITTLE BIT AND THIS 

1425
00:54:16,087 --> 00:54:17,355
IS ESSENTIALLY WHAT HAPPENED.  

1426
00:54:17,355 --> 00:54:20,758
IS WE GOT 120 MILLION DOLLARS 

1427
00:54:20,758 --> 00:54:21,659
ADDED TO OUR BASE BUDGET BUT WE 

1428
00:54:21,659 --> 00:54:24,896
ENDED UP WITH A 96 MILLION 

1429
00:54:24,896 --> 00:54:30,501
DOLLAR TOTAL DECREASE AND IF YOU

1430
00:54:30,501 --> 00:54:36,374
TAKE INTO ACCOUNT BIRD PIE THE  

1431
00:54:36,374 --> 00:54:39,710
IS ABOUT 3.3%. 

1432
00:54:39,710 --> 00:54:40,778
THAT'S OVER 2 MILLION DOLLARS.  

1433
00:54:40,778 --> 00:54:42,980
WE'RE LOSING WHILE WE'RE TRYING 

1434
00:54:42,980 --> 00:54:44,348
TO SAVE MONEY AND THE DOUGH IS 

1435
00:54:44,348 --> 00:54:47,218
BEING IMPACTED.  THE RECIPE, 

1436
00:54:47,218 --> 00:54:49,587
THESE THINGS, THE UNDERLYING 

1437
00:54:49,587 --> 00:54:51,322
ASPECTS OF THE NATIONAL CANCER 

1438
00:54:51,322 --> 00:54:52,089
INSTITUTE WILL BE IMPACTED BY 

1439
00:54:52,089 --> 00:54:54,292
THE DECISIONS THAT WE HAVE TO 

1440
00:54:54,292 --> 00:54:57,061
MAKE IN ORDER TO KEEP PROGRAMS 

1441
00:54:57,061 --> 00:55:01,532
MOVING FORWARD.  A LITTLE MORE, 

1442
00:55:01,532 --> 00:55:04,502
WE NEED TO KEEP IN MIND IS THE 

1443
00:55:04,502 --> 00:55:07,572
NATIONAL CANCER INSTITUTE STILL 

1444
00:55:07,572 --> 00:55:08,039
PRIORITIZES EMERGING 

1445
00:55:08,039 --> 00:55:08,839
OPPORTUNITIES EVEN WHEN THINGS 

1446
00:55:08,839 --> 00:55:12,176
ARE TIGHTENING WE STILL SEE 

1447
00:55:12,176 --> 00:55:13,978
IMPORTANT PRIORITIES THAT EMERGE

1448
00:55:13,978 --> 00:55:15,246
THAT NEED TO BE FUNDED, 

1449
00:55:15,246 --> 00:55:17,248
OPPORTUNITIES THAT NEED TO BE 

1450
00:55:17,248 --> 00:55:18,916
ACTED UPON.  SOME EXAMPLES FROM 

1451
00:55:18,916 --> 00:55:20,484
THE LAST 20 YEARS THAT HAVE GONE

1452
00:55:20,484 --> 00:55:23,788
INTO THE PIE ARE THESE.  THERE'S

1453
00:55:23,788 --> 00:55:26,724
A LOT OF THEM, SOME OF THEM 

1454
00:55:26,724 --> 00:55:27,892
CONTINUING, SOME OF THEM MAYBE 

1455
00:55:27,892 --> 00:55:30,394
HAVE COME TO FRUITION.  BUT WHEN

1456
00:55:30,394 --> 00:55:32,163
WE'RE TALKING ABOUT THINGS THAT 

1457
00:55:32,163 --> 00:55:33,531
HAVE TO BAKE OUT OVER TIME THIS 

1458
00:55:33,531 --> 00:55:35,366
IS JUST A HANDFUL THAT WERE 

1459
00:55:35,366 --> 00:55:38,436
PULLED THERE OUR OWN INTERNET SO

1460
00:55:38,436 --> 00:55:40,905
KUDOS TO PETER'S TEAM FOR THAT 

1461
00:55:40,905 --> 00:55:43,975
BUT A LOT OF THESE THINGS, I 

1462
00:55:43,975 --> 00:55:45,476
TOOK THE SAME TOUR WITH 

1463
00:55:45,476 --> 00:55:47,912
DR. RATHMELL WITH THE OMB AND 

1464
00:55:47,912 --> 00:55:51,182
THEY WERE REALLY IMPRESSED, THE 

1465
00:55:51,182 --> 00:55:53,384
OMB PERSON WAS IMPREZZED WITH 

1466
00:55:53,384 --> 00:55:55,453
SOME OF THE THINGS THAT WE WERE 

1467
00:55:55,453 --> 00:55:56,487
ABLE TO CREATE. 

1468
00:55:56,487 --> 00:55:59,357
THE NCI, THE FREDERICK, THAT THE

1469
00:55:59,357 --> 00:56:00,391
RESEARCH CAN TAKE ADVANTAGE OF 

1470
00:56:00,391 --> 00:56:02,827
AND THOSE THINGS WE CONTINUE TO 

1471
00:56:02,827 --> 00:56:04,228
BUILD UP WHILE AT THE SAME TIME 

1472
00:56:04,228 --> 00:56:05,830
WE HAVE TO SUPPORT SOME OF THE 

1473
00:56:05,830 --> 00:56:07,932
KEY COMPONENTS OF THE NATIONAL 

1474
00:56:07,932 --> 00:56:09,700
CANCER INSTITUTE.  WHAT DOES 

1475
00:56:09,700 --> 00:56:11,402
THAT MEAN FOR US?  THIS IS MY 

1476
00:56:11,402 --> 00:56:15,539
FINAL IMAGE.  OKAY?  THIS IS 

1477
00:56:15,539 --> 00:56:17,575
WHAT THE PIE LOOKS LIKE.  

1478
00:56:17,575 --> 00:56:19,644
THERE'S A LITTLE PIECE TAKEN 

1479
00:56:19,644 --> 00:56:24,015
OUT.  ABOUT 15%.  WHATEVER, FOR 

1480
00:56:24,015 --> 00:56:25,149
A PERFECTLY INNOCENT REASON IS 

1481
00:56:25,149 --> 00:56:27,918
MOVING AWAY AT THE BUDGET.  WE 

1482
00:56:27,918 --> 00:56:29,453
WILL CONTINUE TO MOVE THINGS 

1483
00:56:29,453 --> 00:56:32,323
FORWARD BUT THAT GIVES YOU THE 

1484
00:56:32,323 --> 00:56:32,957
PERSPECTIVE AND GIVES YOU THE 

1485
00:56:32,957 --> 00:56:34,125
NEXT CONVERSATION INTO THE 

1486
00:56:34,125 --> 00:56:35,926
CONTEXT OF HOW WE MOVE FORWARD 

1487
00:56:35,926 --> 00:56:46,437
AS AN INSTITUTE.  THANK YOU.

1488
00:56:50,908 --> 00:56:54,779
>> SO I'M GOING TO TALK
FOR 

1489
00:56:54,779 --> 00:56:56,280
ABOUT SEVEN OR EIGHT MINUTES AND

1490
00:56:56,280 --> 00:56:58,049
THERE SHOULD BE TIME FOR 

1491
00:56:58,049 --> 00:56:59,183
QUESTIONS AND COMMENTS 

1492
00:56:59,183 --> 00:57:00,484
AFTERWARDS FOR BOTH OF US.  I 

1493
00:57:00,484 --> 00:57:02,186
WILL TAKE ALL THE EASY QUESTIONS

1494
00:57:02,186 --> 00:57:04,422
AND WESTIN WILL TAKE THE 

1495
00:57:04,422 --> 00:57:07,325
DIFFICULT ONES.  BUT FIRST, I 

1496
00:57:07,325 --> 00:57:09,393
WANT TO -- I'M GOING TO TALK FOR

1497
00:57:09,393 --> 00:57:13,831
A FEW MINUTES MAINLY ABOUT THE 

1498
00:57:13,831 --> 00:57:16,267
RPG POOL AND WHAT IS SUPPORTED 

1499
00:57:16,267 --> 00:57:18,102
THERE.  BUT BEFORE WE GET TO 

1500
00:57:18,102 --> 00:57:21,906
THAT, I HAVE ONE SLIDE WHICH 

1501
00:57:21,906 --> 00:57:24,408
TELLS YOU ABOUT THE OTHER AREAS 

1502
00:57:24,408 --> 00:57:26,544
WHICH ARE VERY IMPORTANT.  NCI 

1503
00:57:26,544 --> 00:57:29,447
SUPPORTS A LOT OF RESEARCH 

1504
00:57:29,447 --> 00:57:35,920
OUTSIDE THE RPG POOL, SPORE 

1505
00:57:35,920 --> 00:57:37,021
GRANTS, CANCER CENTER SUPPORT 

1506
00:57:37,021 --> 00:57:38,789
GRANTS AND WE NEED TO SUPPORT 

1507
00:57:38,789 --> 00:57:41,359
THESE IN ADDITION TO THE RPGS.  

1508
00:57:41,359 --> 00:57:43,060
AND I HAVE FOUR SLIDES TO TELL 

1509
00:57:43,060 --> 00:57:46,163
YOU A LITTLE BIT ABOUT WHAT HAS 

1510
00:57:46,163 --> 00:57:50,334
HAPPENED OVER TIME WITH GRANT 

1511
00:57:50,334 --> 00:57:53,437
APPLICATIONS AS WELL AS AWARDS. 

1512
00:57:53,437 --> 00:57:56,307
THIS SLIDE SHOWS YOU THAT SINCE 

1513
00:57:56,307 --> 00:57:57,541
2013, THERE HAS BEEN -- AN 

1514
00:57:57,541 --> 00:57:59,744
INCREASE OF MORE THAN TWICE AS 

1515
00:57:59,744 --> 00:58:01,912
MANY APPLICATIONS TO NCI 

1516
00:58:01,912 --> 00:58:06,717
COMPARED TO THE REST OF THE NIH.

1517
00:58:06,717 --> 00:58:10,488
AND THIS IS REALLY BECAUSE THERE

1518
00:58:10,488 --> 00:58:12,890
ARE SO MANY OPPORTUNITIES AT NCI

1519
00:58:12,890 --> 00:58:16,293
IN TERMS OF RESEARCH IN CANCER. 

1520
00:58:16,293 --> 00:58:18,896
REALLY WHAT WESTIN WAS TALKING 

1521
00:58:18,896 --> 00:58:21,198
ABOUT OPPORTUNITIES AND SO A LOT

1522
00:58:21,198 --> 00:58:24,101
OF PEOPLE HAVE WANTED TO APPLY 

1523
00:58:24,101 --> 00:58:24,869
FOR GRANTS AND IT'S MORE THAN WE

1524
00:58:24,869 --> 00:58:33,411
CAN ACTUALLY KEEP UP WITH.  IN 

1525
00:58:33,411 --> 00:58:34,712
ADDITION PEOPLE VOTE WITH THEIR 

1526
00:58:34,712 --> 00:58:36,614
FEET.  THERE ARE WHAT WE CALL 

1527
00:58:36,614 --> 00:58:40,017
MODULAR AWARDS AND NON MODULAR 

1528
00:58:40,017 --> 00:58:41,485
AWARDS.  THE NON MODULAR AWARDS 

1529
00:58:41,485 --> 00:58:43,954
HAVE A MAXIMUM OF 250,000 

1530
00:58:43,954 --> 00:58:48,559
DOLLARS PER YEAR IN DIRECT 

1531
00:58:48,559 --> 00:58:48,793
COSTS. 

1532
00:58:48,793 --> 00:58:51,162
WHEREAS THE NON MODULAR ALMOST 

1533
00:58:51,162 --> 00:58:54,331
ALWAYS ARE GOING ABOVE THAT. 

1534
00:58:54,331 --> 00:58:56,767
AND THERE IS A TENTATIVE CEILING

1535
00:58:56,767 --> 00:58:59,737
OF 499,000 DOLLARS BUT IF YOU 

1536
00:58:59,737 --> 00:59:01,906
APPLY TO THE DIVISION IN ADVANCE

1537
00:59:01,906 --> 00:59:04,975
YOU CAN GET AN APPROVAL TO APPLY

1538
00:59:04,975 --> 00:59:10,915
FOR A GRANT THAT IS HIGHER THAN 

1539
00:59:10,915 --> 00:59:11,816
499,000.  BUT WHAT I WANT YOU TO

1540
00:59:11,816 --> 00:59:15,686
SEE FROM THIS SLIDE IS THAT IN 

1541
00:59:15,686 --> 00:59:17,621
2012, THE MAJORITY OF THE AWARDS

1542
00:59:17,621 --> 00:59:22,626
WERE MODULAR.  SO THEY WERE 

1543
00:59:22,626 --> 00:59:24,595
250,000 DOLLARS OR LESS.  FAST 

1544
00:59:24,595 --> 00:59:28,866
FORWARD TO 2023.  AND BASICALLY 

1545
00:59:28,866 --> 00:59:31,569
ONLY ONE IN SEVEN OF THE AWARDS 

1546
00:59:31,569 --> 00:59:33,270
WERE MODULAR AND SO IT MEANS 

1547
00:59:33,270 --> 00:59:36,740
THAT THE OTHERS WERE NON MODULAR

1548
00:59:36,740 --> 00:59:38,909
AND THIS -- NOT JUST WITH 

1549
00:59:38,909 --> 00:59:41,312
INFLATION BUT THIS ACCOUNTS FOR 

1550
00:59:41,312 --> 00:59:44,415
THE INCREASED COST ALMOST EVERY 

1551
00:59:44,415 --> 00:59:47,518
YEAR TOWARD THE AVERAGE GRANT 

1552
00:59:47,518 --> 00:59:55,292
THAT WE MAKE.  NEVERTHELESS, 

1553
00:59:55,292 --> 00:59:58,028
THIS LOOKS AT THE PAY LINE 

1554
00:59:58,028 --> 00:59:58,963
EXPERIENCED INVESTIGATORS THAT 

1555
00:59:58,963 --> 01:00:00,431
IS IN BLUE.  THAT'S THE BLUE 

1556
01:00:00,431 --> 01:00:01,799
LINE AND THEN THE GREEN 

1557
01:00:01,799 --> 01:00:03,467
REPRESENTS THE NUMBER OF AWARDS 

1558
01:00:03,467 --> 01:00:07,271
THAT WE'VE BEEN ABLE TO GIVE OUT

1559
01:00:07,271 --> 01:00:10,007
EACH YEAR AND WHAT I HOPE YOU 

1560
01:00:10,007 --> 01:00:12,910
CAN APPRECIATE IS THAT WE 

1561
01:00:12,910 --> 01:00:18,949
REACHED NADIR IN 2019 OF 8%.  

1562
01:00:18,949 --> 01:00:23,120
AND IT WAS -- YOU KNOW, BEYOND 

1563
01:00:23,120 --> 01:00:25,422
NONSUSTAINABLE.  AND WE HAVE 

1564
01:00:25,422 --> 01:00:28,893
ESSENTIALLY PRIORITIZED THE RPG 

1565
01:00:28,893 --> 01:00:31,128
POOL GIVING PROPORTIONALLY MORE 

1566
01:00:31,128 --> 01:00:33,697
FUNDS TO THE RPG POOL EACH YEAR 

1567
01:00:33,697 --> 01:00:35,499
WHICH IS RELATIVELY EASY TO DO 

1568
01:00:35,499 --> 01:00:38,636
WHEN THERE ARE INCREASES TO THE 

1569
01:00:38,636 --> 01:00:40,871
BUDGET.  AND WHAT I HOPE YOU CAN

1570
01:00:40,871 --> 01:00:44,441
APPRECIATE IS THAT BY 2023, WE 

1571
01:00:44,441 --> 01:00:47,545
HAD GONE FROM LITTLE UNDER 700 

1572
01:00:47,545 --> 01:00:53,384
AWARDS IN 2019 TO JUST UNDER 

1573
01:00:53,384 --> 01:00:55,252
900.  THIS YEAR, BECAUSE WE HAD 

1574
01:00:55,252 --> 01:00:58,188
TO GO DOWN TO THE 10TH 

1575
01:00:58,188 --> 01:00:59,557
PERCENTILE THE NUMBER OF AWARDS 

1576
01:00:59,557 --> 01:01:02,126
IS GOING TO DECREASE, WE WILL 

1577
01:01:02,126 --> 01:01:06,030
STILL BE OVER 800 BUT WE WON'T 

1578
01:01:06,030 --> 01:01:09,366
BE AT THE NUMBER OF 893 THAT WE 

1579
01:01:09,366 --> 01:01:13,370
HAD LAST YEAR.  THIS IS FOR ALL 

1580
01:01:13,370 --> 01:01:15,806
INVESTIGATORS.  WHAT IF WE DRILL

1581
01:01:15,806 --> 01:01:18,742
DOWN ON EARLY STAGE 

1582
01:01:18,742 --> 01:01:19,810
INVESTIGATORS?  THE TREND IN 

1583
01:01:19,810 --> 01:01:23,180
TERMS OF THE PAYLINE HAS BEEN 

1584
01:01:23,180 --> 01:01:28,886
CONSISTENTLY UPWARD FROM 2016 A 

1585
01:01:28,886 --> 01:01:30,688
12 PERCENTILE PAY LINE GOING UP 

1586
01:01:30,688 --> 01:01:33,290
PRETTY MUCH EACH YEAR SO THAT IN

1587
01:01:33,290 --> 01:01:38,495
2023, IT WAS IN THE 17TH 

1588
01:01:38,495 --> 01:01:41,298
PERCENTILE AND WE KEPT IT FOR 

1589
01:01:41,298 --> 01:01:44,868
2024 AT THE 7TH PERCENTILE FOR 

1590
01:01:44,868 --> 01:01:47,838
EARLY STAGE INVESTIGATORS.  

1591
01:01:47,838 --> 01:01:51,508
ALTHOUGH, THE THE PAY LINE FOR 

1592
01:01:51,508 --> 01:01:53,911
THE EXPERIENCED INVESTIGATORS 

1593
01:01:53,911 --> 01:01:56,413
WENT DOWN TO 10.  WHAT I HOPE 

1594
01:01:56,413 --> 01:01:58,649
YOU CAN APPRECIATE IS BACK IN 

1595
01:01:58,649 --> 01:02:00,784
2016-17 WE WERE FUNDING FEWER 

1596
01:02:00,784 --> 01:02:03,320
THAN 100 EARLY STAGE 

1597
01:02:03,320 --> 01:02:06,390
INVESTIGATORS: AND STARTING WITH

1598
01:02:06,390 --> 01:02:09,827
2018, IT HAS BEEN SUBSTANTIALLY 

1599
01:02:09,827 --> 01:02:15,933
OVER 100.  2021-22 A LITTLE OVER

1600
01:02:15,933 --> 01:02:19,470
130 THIS PAST YEAR IT WAS 120.  

1601
01:02:19,470 --> 01:02:21,438
MY UNDERSTANDING IS WE ARE ON 

1602
01:02:21,438 --> 01:02:26,810
TRACK TO BE OVER 120 FOR FY24 

1603
01:02:26,810 --> 01:02:27,878
BUT PROBABLY NOT QUITE AS HIGH 

1604
01:02:27,878 --> 01:02:33,150
AS IN THE HIGH YEARS OF '21 AND 

1605
01:02:33,150 --> 01:02:36,320
'22.  MY LAST TWO SLIDES ARE 

1606
01:02:36,320 --> 01:02:41,592
REALLY TALKING ABOUT WHO WHAT 

1607
01:02:41,592 --> 01:02:43,661
HAPPENS WHEN YOU HAVE A 

1608
01:02:43,661 --> 01:02:44,862
CONSTRAINED BUDGET.  WESTIN 

1609
01:02:44,862 --> 01:02:47,531
DIDN'T POINT OUT THAT OUR BUDGET

1610
01:02:47,531 --> 01:02:49,466
FOR FY24 WAS ACTUALLY 96 MILLION

1611
01:02:49,466 --> 01:02:51,835
DOLLARS LESS THAT IS IN ACTUAL 

1612
01:02:51,835 --> 01:02:54,204
DOLLARS NOT INFLATED DOLLARS 

1613
01:02:54,204 --> 01:02:59,309
THAN WE HAD IN FY 23 AND THIS IS

1614
01:02:59,309 --> 01:03:04,882
JUST A SMALL EXAMPLE WITH THESE 

1615
01:03:04,882 --> 01:03:08,218
DIFFERENT BULLET POINTS OF AREAS

1616
01:03:08,218 --> 01:03:10,320
WE NEED TO THINK ABOUT 

1617
01:03:10,320 --> 01:03:11,722
PRIORITIZATION.  I WAS GOING TO 

1618
01:03:11,722 --> 01:03:13,257
ADD MORE BUT DR. RATHMELL TOLD 

1619
01:03:13,257 --> 01:03:15,993
ME WE WOULD NEED TO GIVE OUT 

1620
01:03:15,993 --> 01:03:17,628
BINOCULARS IF I DID THAT SO JUST

1621
01:03:17,628 --> 01:03:19,830
TO GO THROUGH THESE QUICKLY.  

1622
01:03:19,830 --> 01:03:22,199
NEW STANDARD OF CARE VERSUS 

1623
01:03:22,199 --> 01:03:24,068
RESEARCH TO INCREASE UPTAKE OF 

1624
01:03:24,068 --> 01:03:26,804
CURRENT STANDARD OF CARE AND WE 

1625
01:03:26,804 --> 01:03:27,438
ALREADY HEARD DURING ESPECIALLY 

1626
01:03:27,438 --> 01:03:29,973
DURING THE QUESTION PERIOD ABOUT

1627
01:03:29,973 --> 01:03:31,475
THE IMPORTANCE OF INCREASING 

1628
01:03:31,475 --> 01:03:33,877
UPTAKE OF CURRENT STANDARD OF 

1629
01:03:33,877 --> 01:03:35,546
CARE.  RPG POOL, I'LL COME BACK 

1630
01:03:35,546 --> 01:03:40,718
TO THAT IN THE LAST SLIDE.  

1631
01:03:40,718 --> 01:03:41,785
CANCER TRAINING, CANCER CENTER 

1632
01:03:41,785 --> 01:03:44,388
TO THE SPORE GRANTS.  SHOULD WE 

1633
01:03:44,388 --> 01:03:47,357
CONTINUE TO GIVE INCREASES IN 

1634
01:03:47,357 --> 01:03:49,693
THE FACE OF FLAT BUDGETS?  

1635
01:03:49,693 --> 01:03:50,794
SHOULD WE CONTINUE TO INCREASE 

1636
01:03:50,794 --> 01:03:53,630
THE NUMBER OF DESIGNATED CANCER 

1637
01:03:53,630 --> 01:03:56,867
CENTERS WHICH ALSO INCREASE THE 

1638
01:03:56,867 --> 01:04:01,739
COST OF -- FOR THE CANCER CENTER

1639
01:04:01,739 --> 01:04:04,708
LINE.  SPORE GRANTS.  VERY 

1640
01:04:04,708 --> 01:04:07,044
IMPORTANT.  CANCER DISPARITIES, 

1641
01:04:07,044 --> 01:04:09,379
COMMUNITY ENGAGEMENT.  JUST A 

1642
01:04:09,379 --> 01:04:11,648
SUBSET AND THEN THE LAST SLIDE 

1643
01:04:11,648 --> 01:04:14,485
JUST TALKING ABOUT WHAT WE HAVE 

1644
01:04:14,485 --> 01:04:16,820
THOUGHT ABOUT IN TERMS OF 

1645
01:04:16,820 --> 01:04:19,389
PRIORITIZATION.  JUST FOR SOME 

1646
01:04:19,389 --> 01:04:21,725
OF THESE AREAS AND NOT EVERYONE 

1647
01:04:21,725 --> 01:04:27,030
IS GOING TO AGREE.  FOR EXAMPLE,

1648
01:04:27,030 --> 01:04:28,298
TO PRIORITIZE THE DEVELOPMENT OF

1649
01:04:28,298 --> 01:04:30,801
NEW STANDARDS OF CARE AND THE 

1650
01:04:30,801 --> 01:04:32,136
DEVELOPMENT OF NEW STANDARDS OF 

1651
01:04:32,136 --> 01:04:34,605
CARE AS WAS POINTED OUT DURING 

1652
01:04:34,605 --> 01:04:39,443
THE QUESTION PERIOD OFTEN MAY 

1653
01:04:39,443 --> 01:04:41,712
EXACERBATE GAPS AND INCREASE 

1654
01:04:41,712 --> 01:04:43,313
CANCER DISPARITIES BUT 

1655
01:04:43,313 --> 01:04:44,882
DR. RATHMELL ANNOUNCED AT THE 

1656
01:04:44,882 --> 01:04:47,151
BEGINNING OF THIS YEAR DOWN AT 

1657
01:04:47,151 --> 01:04:49,019
THE WHITE HOUSE THAT THERE IS A 

1658
01:04:49,019 --> 01:04:51,455
CERVICAL CANCER SCREENING TRIAL 

1659
01:04:51,455 --> 01:04:55,325
CALLED EITHER THE SHIP TRIAL OR 

1660
01:04:55,325 --> 01:04:58,162
THE LAST MILE UNDER THE AEGIS OF

1661
01:04:58,162 --> 01:05:00,664
DR. PHIL CASTLE AND HIS 

1662
01:05:00,664 --> 01:05:02,766
COLLEAGUES IN THE DIVISION OF 

1663
01:05:02,766 --> 01:05:03,934
CANCER PREVENTION THAT IS TRYING

1664
01:05:03,934 --> 01:05:07,938
TO MAKE IT FDA APPROVABLE FOR 

1665
01:05:07,938 --> 01:05:10,808
SELF-SAMPLING OF WOMEN THAT 

1666
01:05:10,808 --> 01:05:12,910
ACTUALLY WE HOPE WILL DECREASE 

1667
01:05:12,910 --> 01:05:17,514
THE GAP IN TERMS OF WHO IS BEING

1668
01:05:17,514 --> 01:05:20,818
UNDERSCREENED.  I THINK FOR THE 

1669
01:05:20,818 --> 01:05:22,486
RPG POOL TO PROTECT NEW 

1670
01:05:22,486 --> 01:05:23,687
INITIATED AWARDS ESPECIALLY 

1671
01:05:23,687 --> 01:05:26,089
EARLY STAGE INVESTIGATORS AND 

1672
01:05:26,089 --> 01:05:29,693
REDUCING INVESTMENT IN THE RFAS.

1673
01:05:29,693 --> 01:05:32,863
THEY'RE VERY IMPORTANT.  AND AS 

1674
01:05:32,863 --> 01:05:35,199
YOU HAVE HEARD EARLY CANCERS IS 

1675
01:05:35,199 --> 01:05:37,467
GOING TO BE SORT OF A VERY 

1676
01:05:37,467 --> 01:05:39,336
IMPORTANT AREA BUT WE ARE GOING 

1677
01:05:39,336 --> 01:05:42,573
TO BE DOING FEWER RFAS SO THAT 

1678
01:05:42,573 --> 01:05:46,443
WE CAN PROTECT INVESTIGATOR 

1679
01:05:46,443 --> 01:05:48,879
INITIATED RESEARCH.  AND ONE OF 

1680
01:05:48,879 --> 01:05:52,216
THE PROBLEMS OF COURSE IS THAT 

1681
01:05:52,216 --> 01:05:54,051
WE LOVE ALL THE TIME TO BE ABLE 

1682
01:05:54,051 --> 01:05:59,656
TO GIVE IN THE OUT YEARS 100% OF

1683
01:05:59,656 --> 01:06:03,060
GRANTS BUT IN ORDER TO TRY TO 

1684
01:06:03,060 --> 01:06:08,799
MAINTAIN THE NUMBER OF AWARDS IT

1685
01:06:08,799 --> 01:06:09,533
HAS BEEN NECESSARY TO GIVE LESS 

1686
01:06:09,533 --> 01:06:12,002
THAN 100%.  AND THEN CANCER 

1687
01:06:12,002 --> 01:06:14,638
TRAINING.  TRYING TO MAINTAIN 

1688
01:06:14,638 --> 01:06:18,942
THE NUMBER OF PEOPLE THAT WE ARE

1689
01:06:18,942 --> 01:06:22,846
TRAINING THROUGH OLIVER'S 

1690
01:06:22,846 --> 01:06:23,747
TRAINING BRANCH AND ALSO WITH 

1691
01:06:23,747 --> 01:06:26,683
WHAT USED TO BE THE CENTER 

1692
01:06:26,683 --> 01:06:29,486
FOR -- TO REDUCE CANCER HEALTH 

1693
01:06:29,486 --> 01:06:31,722
DISPARITIES AND NOW THE CANCER 

1694
01:06:31,722 --> 01:06:36,894
CENTER FOR HEALTH EQUITY THAT 

1695
01:06:36,894 --> 01:06:38,795
SONYA SPRINGFIELD RUNS.  THIS 

1696
01:06:38,795 --> 01:06:40,497
HAS KIND OF BEEN A QUICK 

1697
01:06:40,497 --> 01:06:42,332
OVERVIEW OF DIFFERENT ASPECTS OF

1698
01:06:42,332 --> 01:06:44,835
THE BUDGET AND WESTIN AND I ARE 

1699
01:06:44,835 --> 01:06:47,104
HAPPY TO TRY TO ANSWER YOUR 

1700
01:06:47,104 --> 01:06:48,839
QUESTIONS AND ALSO VERY 

1701
01:06:48,839 --> 01:06:49,473
INTERESTED IN YOUR COMMENTS.  

1702
01:06:49,473 --> 01:06:54,578
THANK YOU VERY MUCH.

1703
01:06:54,578 --> 01:06:58,482
>> THANKS.  THANK YOU SO
MUCH.  

1704
01:06:58,482 --> 01:06:59,349
GREAT PRESENTATION.  THE FLOOR 

1705
01:06:59,349 --> 01:07:09,893
IS NOW OPEN FOR QUESTIONS.  Z  

1706
01:07:11,061 --> 01:07:14,564
SO I HAVE ONE, I WAS INTERESTED 

1707
01:07:14,564 --> 01:07:17,467
IN THE HISTOGRAM THAT SHOWED THE

1708
01:07:17,467 --> 01:07:19,836
SINGLE POSITIONS.  IS THAT 

1709
01:07:19,836 --> 01:07:20,871
INCREASE ASSOCIATED WITH AN 

1710
01:07:20,871 --> 01:07:24,875
INCREASE IN TEAM SCIENCE OR MPI 

1711
01:07:24,875 --> 01:07:25,108
GRANTS?

1712
01:07:25,108 --> 01:07:29,546
>> I WOULD SAY IN GENERAL
THE 

1713
01:07:29,546 --> 01:07:31,481
MULTI-PI APPLICATIONS ARE GOING 

1714
01:07:31,481 --> 01:07:32,683
TO BE NON MODULAR IN ORDER TO BE

1715
01:07:32,683 --> 01:07:36,787
ABLE TO PAY FOR ENOUGH OF THEM. 

1716
01:07:36,787 --> 01:07:37,754
DIANE CENTER FOR RESEARCH 

1717
01:07:37,754 --> 01:07:39,056
STRATEGY IS HERE.  DO YOU WANT 

1718
01:07:39,056 --> 01:07:49,499
TO SAY MORE ABOUT THAT? .

1719
01:07:56,473 --> 01:07:58,642
>> SO THAT COULD POSSIBLY 

1720
01:07:58,642 --> 01:08:02,079
EXPLAIN THE DECREASE.

1721
01:08:02,079 --> 01:08:03,447
>> I WAS CURIOUS THE
FUNDING 

1722
01:08:03,447 --> 01:08:04,881
LINE AND OTHER TRAINING GRANTS. 

1723
01:08:04,881 --> 01:08:08,085
HOW HAS THAT BEEN OVER THE 

1724
01:08:08,085 --> 01:08:08,318
LAST....

1725
01:08:08,318 --> 01:08:11,588
>> WE ACTUALLY OVER THE
LAST FEW

1726
01:08:11,588 --> 01:08:14,358
YEARS HAVE PRIORITIZED 

1727
01:08:14,358 --> 01:08:17,627
INDIVIDUAL AWARDS OVER THE T32 

1728
01:08:17,627 --> 01:08:19,363
GRANTS ON THE OTHER HAND WE 

1729
01:08:19,363 --> 01:08:20,864
STILL HAVE GRANTS OLIVER BOG 

1730
01:08:20,864 --> 01:08:22,499
HER, HEAD OF THE CENTER FOR 

1731
01:08:22,499 --> 01:08:27,838
CANCER STRAINING IS  -- TRAINING

1732
01:08:27,838 --> 01:08:31,408
IS HERE. WE WILL AANSWER ALL OF 

1733
01:08:31,408 --> 01:08:36,880
YOUR QUESTIONS AND MORE.

1734
01:08:36,880 --> 01:08:40,684
>> YEAH, SO I DON'T KNOW
IF YOU 

1735
01:08:40,684 --> 01:08:44,354
CAN HEAR.  ONE OF THE THINGS WE 

1736
01:08:44,354 --> 01:08:49,893
HEAR IS ABOUT THE SCOPE PROGRAM.

1737
01:08:49,893 --> 01:08:51,561
CAN YOU HEAR ME NOW?  OKAY.  SO 

1738
01:08:51,561 --> 01:08:53,864
ONE OF THE THINGS WE HEAR ABOUT 

1739
01:08:53,864 --> 01:08:56,933
OVER AND OVER AGAIN IS THE SPORE

1740
01:08:56,933 --> 01:08:58,769
PROGRAM AND IS IT GOING TO 

1741
01:08:58,769 --> 01:09:00,170
CONTINUE?  IT ALWAYS FEELS LIKE 

1742
01:09:00,170 --> 01:09:03,006
IT'S A LITTLE BIT AT RISK 

1743
01:09:03,006 --> 01:09:05,709
SOMEHOW.  BECAUSE PREVIOUS NCI 

1744
01:09:05,709 --> 01:09:07,911
DIRECTORS OR NIH DIRECTORS HAVE 

1745
01:09:07,911 --> 01:09:09,479
MENTIONED THAT THIS -- IT MIGHT 

1746
01:09:09,479 --> 01:09:10,914
NOT BE A SUSTAINABLE PROGRAM.  

1747
01:09:10,914 --> 01:09:12,949
WHEN YOU LOOK AT IT IN YOUR 

1748
01:09:12,949 --> 01:09:15,052
BUDGET IS THIS SOMETHING THAT 

1749
01:09:15,052 --> 01:09:16,820
YOU THIS WILL CONTINUE TO BE A 

1750
01:09:16,820 --> 01:09:18,588
SUSTAINABLE PROGRAM?

1751
01:09:18,588 --> 01:09:21,658
>> YES.  SO I... WE'RE
VERY 

1752
01:09:21,658 --> 01:09:24,327
FORTUNATE DR. TOBY IS HERE WHO 

1753
01:09:24,327 --> 01:09:25,362
IS THE HEAD OF THE SPORE PROGRAM

1754
01:09:25,362 --> 01:09:27,798
MAY WANT TO SAY MORE BUT I THINK

1755
01:09:27,798 --> 01:09:29,733
OF THE SPORE PROGRAM A LITTLE 

1756
01:09:29,733 --> 01:09:31,635
BIT LIKE WHAT MARK TWAIN SAID 

1757
01:09:31,635 --> 01:09:35,939
ABOUT HIS DEATH.  GREATLY 

1758
01:09:35,939 --> 01:09:41,945
EXAGGERATED.  THE SPORE PROGRAM 

1759
01:09:41,945 --> 01:09:43,113
HAS BEEN CONTINUALLY DOING MORE 

1760
01:09:43,113 --> 01:09:47,117
WITH LESS JUST LIKE MANY OTHER 

1761
01:09:47,117 --> 01:09:50,687
AREAS.  AND AS DR. RATHMELL 

1762
01:09:50,687 --> 01:09:51,955
MENTIONED, WE NOW HAVE IN THE 

1763
01:09:51,955 --> 01:09:55,692
SPORE PROGRAM HEALTH DIVERSITY 

1764
01:09:55,692 --> 01:09:57,561
AS WELL AS THE INDIVIDUAL 

1765
01:09:57,561 --> 01:10:00,430
CANCER -- THE INDIVIDUAL CANCER 

1766
01:10:00,430 --> 01:10:02,766
TYPES.  THIS HAS BEEN ASSOCIATED

1767
01:10:02,766 --> 01:10:04,768
WITH A SMALL INCREASE TO THE 

1768
01:10:04,768 --> 01:10:06,770
BUDGET FOR THE SPORE PROGRAM BUT

1769
01:10:06,770 --> 01:10:08,872
LIKE EVERYTHING ELSE THAT WE DO,

1770
01:10:08,872 --> 01:10:10,907
GREATLY UNDERSTOOD FUNDED.  

1771
01:10:10,907 --> 01:10:12,309
DR. HECK, DO YOU WANT TO SAY 

1772
01:10:12,309 --> 01:10:18,849
SOMETHING?

1773
01:10:18,849 --> 01:10:29,526
>> NO.  RIGHT THERE.  SHE
HAS TO

1774
01:10:29,526 --> 01:10:32,863
UNMUTE IT.  YEAH, SHE HAS TO 

1775
01:10:32,863 --> 01:10:35,265
UNMUTE IT.

1776
01:10:35,265 --> 01:10:42,706
>> OH, GOOD.  I DON'T HAVE
THAT 

1777
01:10:42,706 --> 01:10:44,875
MUCH TO SAY EXCEPT THAT BACK IN 

1778
01:10:44,875 --> 01:10:47,677
2015 THERE WAS AN EVALUATION OF 

1779
01:10:47,677 --> 01:10:49,112
THE SPORE PROGRAM AND IT WAS 

1780
01:10:49,112 --> 01:10:54,317
REALLY A DMRGLOWING EVALUATION. 

1781
01:10:54,317 --> 01:10:56,019
THEY DID MAKE SOME SUGGESTIONS 

1782
01:10:56,019 --> 01:10:58,221
WHICH WE INCORPORATED BUT LIKE 

1783
01:10:58,221 --> 01:11:00,857
EVERY PROGRAM IN THE LAST COUPLE

1784
01:11:00,857 --> 01:11:03,627
OF YEARS, WE HAVE HAD TO TAKE 

1785
01:11:03,627 --> 01:11:06,663
CUTS AND SO WE HAVE ACTUALLY 

1786
01:11:06,663 --> 01:11:11,501
LOST SEVEN SPORES THIS PAST YEAR

1787
01:11:11,501 --> 01:11:12,936
BECAUSE OF BUDGET CUTS.  WE'RE 

1788
01:11:12,936 --> 01:11:16,640
HOPING THAT THAT IS NOT GOING TO

1789
01:11:16,640 --> 01:11:18,975
BE FOREBODING FOR THE FUTURE BUT

1790
01:11:18,975 --> 01:11:20,911
WE'RE DOING VERY, VERY WELL AND 

1791
01:11:20,911 --> 01:11:25,982
I SHOULD ADD THAT WE HAVE AN RFA

1792
01:11:25,982 --> 01:11:28,351
OUT NOW WHICH IS A COMPANION TO 

1793
01:11:28,351 --> 01:11:30,820
THE SPORE PROGRAM WHICH IS IN 

1794
01:11:30,820 --> 01:11:34,291
CANCER HEALTH DISPARITIES AND 

1795
01:11:34,291 --> 01:11:38,528
THERE HAS BEEN TREMENDOUS 

1796
01:11:38,528 --> 01:11:40,230
INTEREST IN APPLYING FOR THIS, 

1797
01:11:40,230 --> 01:11:42,032
THE APPLICATIONS ARE DUE AT THE 

1798
01:11:42,032 --> 01:11:44,868
END OF THIS MONTH.  AND WE'RE 

1799
01:11:44,868 --> 01:11:46,736
REALLY EXCITED.  WE'VE ALREADY 

1800
01:11:46,736 --> 01:11:51,374
DONE SOMETHING LIKE 25 

1801
01:11:51,374 --> 01:11:52,342
PRE-APPLICATION CONSULTATIONS 

1802
01:11:52,342 --> 01:11:53,810
WITH GROUPS THAT ARE INTERESTED 

1803
01:11:53,810 --> 01:11:55,579
IN THIS.  AND WE'RE HOPING THAT 

1804
01:11:55,579 --> 01:12:00,083
WE'RE GOING TO HAVE A VERY 

1805
01:12:00,083 --> 01:12:02,686
ROBUST, YOU KNOW, APPLICATION 

1806
01:12:02,686 --> 01:12:05,755
GROUP COMING IN.  I WOULD SAY 

1807
01:12:05,755 --> 01:12:08,959
THE SPORES ARE VERY HEALTHY.  WE

1808
01:12:08,959 --> 01:12:11,061
COULD USE MORE MONEY OF COURSE. 

1809
01:12:11,061 --> 01:12:16,199
BUT THE RESEARCH THAT IS COMING 

1810
01:12:16,199 --> 01:12:20,237
OUT IS REALLY QUITE AMAZING.  

1811
01:12:20,237 --> 01:12:23,840
WE'VE GOTTEN MANY COLLABORATIONS

1812
01:12:23,840 --> 01:12:26,076
BETWEEN SPORES IN INDUSTRY AND 

1813
01:12:26,076 --> 01:12:30,180
HAVE ALLOWED FOR DEVELOPMENT OF 

1814
01:12:30,180 --> 01:12:31,281
NEW AGENTS THAT ARE IN THE 

1815
01:12:31,281 --> 01:12:33,049
CLINIC NOW.  SO THANK YOU VERY 

1816
01:12:33,049 --> 01:12:37,721
MUCH FOR THE QUESTION.

1817
01:12:37,721 --> 01:12:40,890
>> THAT'S GREAT TO HEAR.

1818
01:12:40,890 --> 01:12:43,693
>> ONE -- IT'S A LITTLE 

1819
01:12:43,693 --> 01:12:45,495
CONTROVERSIAL AND PROVOCATIVE.  

1820
01:12:45,495 --> 01:12:49,266
WESTIN, YOU TALKED ABOUT THE 

1821
01:12:49,266 --> 01:12:51,601
OVEN AND THE MORTGAGE COSTS THAT

1822
01:12:51,601 --> 01:12:56,006
GO INTO BAKING COOKIES AND PIES.

1823
01:12:56,006 --> 01:12:58,241
FOR US AN EXTRA MILE MEAL THAT 

1824
01:12:58,241 --> 01:13:00,210
EQUATE TO INDIRECTS. 

1825
01:13:00,210 --> 01:13:02,612
HOW DOES THAT PIE BREAK DOWN IN 

1826
01:13:02,612 --> 01:13:04,114
TERMS OF THE OVERALL BUDGET AND 

1827
01:13:04,114 --> 01:13:08,885
IS THAT SOMETHING WE THINK ABOUT

1828
01:13:08,885 --> 01:13:10,654
IN DIRECT WAYS?

1829
01:13:10,654 --> 01:13:12,889
>> YOU'RE TALKING ABOUT
INDIRECT

1830
01:13:12,889 --> 01:13:14,658
RATES INSIDE OF THE COMMITTEE.

1831
01:13:14,658 --> 01:13:16,893
>> YES, IN TERMS OF THE
GRANTS.

1832
01:13:16,893 --> 01:13:19,195
>> SO THE INDIRECT RATE IS

1833
01:13:19,195 --> 01:13:20,897
OFTEN -- IS MANAGED BY AN 

1834
01:13:20,897 --> 01:13:21,665
ENTIRELY DIFFERENT ORGANIZATION 

1835
01:13:21,665 --> 01:13:23,500
OUTSIDE OF NIH'S CONTROL.

1836
01:13:23,500 --> 01:13:24,868
>> SO WE'RE ONLY FUNDING
THE 

1837
01:13:24,868 --> 01:13:25,101
DIRECTS.

1838
01:13:25,101 --> 01:13:26,403
>> NO, WE FUND IT.

1839
01:13:26,403 --> 01:13:28,405
>> THAT'S WHAT I MEAN.

1840
01:13:28,405 --> 01:13:30,173
>> WHAT HAPPENS -- IT'S A 

1841
01:13:30,173 --> 01:13:31,574
SIGNIFICANT AMOUNT.  I CAN'T 

1842
01:13:31,574 --> 01:13:35,745
TELL YOU THE EXACT PERCENTAGE.

1843
01:13:35,745 --> 01:13:37,380
>> IT WOULD BE GREAT TO
KNOW.

1844
01:13:37,380 --> 01:13:41,718
>> WITH RO 1 AWARDS, THE
AWARDS 

1845
01:13:41,718 --> 01:13:43,987
IS ABOUT 60% OF THE DIRECT IS 

1846
01:13:43,987 --> 01:13:46,323
THEN PUT ON TOP OF THAT WITH 

1847
01:13:46,323 --> 01:13:48,058
INDIRECT.  OKAY?  SO YOU CAN 

1848
01:13:48,058 --> 01:13:49,292
THINK OF TWO-THIRDS ONE-THIRD.  

1849
01:13:49,292 --> 01:13:58,268
SOMETHING ALONG THOSE LINES.

1850
01:13:58,268 --> 01:14:00,036
>> OKAY.  I THINK WE'RE
JUST 

1851
01:14:00,036 --> 01:14:01,504
ABOUT RIGHT ON TIME UNLESS 

1852
01:14:01,504 --> 01:14:03,473
THERE'S ANY.  ONE MORE QUESTION.

1853
01:14:03,473 --> 01:14:05,775
>> SO ON THE SLIDE AROUND
THINGS

1854
01:14:05,775 --> 01:14:07,711
THAT NIBBLE AWAY AND YOU TALKED 

1855
01:14:07,711 --> 01:14:08,878
ABOUT A LOT OF DIFFERENT 

1856
01:14:08,878 --> 01:14:11,348
PROGRAMS.  I KNOW THE TERM 

1857
01:14:11,348 --> 01:14:14,651
UNFUNDING MANDATE CAN HAVE A 

1858
01:14:14,651 --> 01:14:15,218
PEJORATIVE CONTEXT BECAUSE 

1859
01:14:15,218 --> 01:14:19,289
THOSE -- THOSE PROGRAMS ARE 

1860
01:14:19,289 --> 01:14:21,991
INCREDIBLY IMPORTANT HOWEVER I 

1861
01:14:21,991 --> 01:14:23,860
KNOW THAT YOU ARE LEGISLATIVELY 

1862
01:14:23,860 --> 01:14:25,762
MANDATED TO DO THINGS AT TIMES 

1863
01:14:25,762 --> 01:14:27,564
WITHOUT EXTRA FUNDS.  I OFFER 

1864
01:14:27,564 --> 01:14:29,399
THIS AS AN IDEA, WE IN A 

1865
01:14:29,399 --> 01:14:31,501
COALITION FOR FDA CALLED THE 

1866
01:14:31,501 --> 01:14:35,338
ALLIANCE FOR A STRONGER FDA, I 

1867
01:14:35,338 --> 01:14:39,776
CHAIRED IT I WAS CHAIR FOR 

1868
01:14:39,776 --> 01:14:41,578
YEARS.  WE SAW THE MANDATES.  

1869
01:14:41,578 --> 01:14:43,546
AND THAT IMPACTED STAFF WHEN 

1870
01:14:43,546 --> 01:14:44,881
THEY UNDERSTOOD, HEY, YOU'RE 

1871
01:14:44,881 --> 01:14:46,349
TELLING THEM TO DO ALL THESE 

1872
01:14:46,349 --> 01:14:48,151
THINGS BUT YOU'RE ONLY GIVING 

1873
01:14:48,151 --> 01:14:49,686
THEM THIS SO JUST AS YOU'RE 

1874
01:14:49,686 --> 01:14:51,087
THINKING ABOUT, I KNOW YOU GUYS 

1875
01:14:51,087 --> 01:14:52,522
DON'T ADVOCATE BUT AS YOU'RE 

1876
01:14:52,522 --> 01:14:54,758
TELLING YOUR STORY AND THE 

1877
01:14:54,758 --> 01:14:55,458
ADVOCATES ARE TELLING THEIR 

1878
01:14:55,458 --> 01:14:56,593
STORY THAT MIGHT BE HELPFUL.  

1879
01:14:56,593 --> 01:14:58,361
THAT NEW PROGRAMS ARE GREAT.  

1880
01:14:58,361 --> 01:15:00,830
THE NEED IS GREAT.  ESPECIALLY 

1881
01:15:00,830 --> 01:15:02,232
FOR RARE CANCERS BUT IF YOU'RE 

1882
01:15:02,232 --> 01:15:04,601
NOT GETTING EXTRA MONEY THAT 

1883
01:15:04,601 --> 01:15:06,836
COMES AT A COST.  SO --

1884
01:15:06,836 --> 01:15:08,872
>> ABSOLUTELY.

1885
01:15:08,872 --> 01:15:12,375
>> THANKS FOR THAT
COMMENT.

1886
01:15:12,375 --> 01:15:15,145
>> THANK YOU, DOUG AND
WESTIN.  

1887
01:15:15,145 --> 01:15:18,114
NEXT IS A PRESENTATION ON NCI 

1888
01:15:18,114 --> 01:15:22,519
SUPPORT OF EARLY CAREER CANCER 

1889
01:15:22,519 --> 01:15:24,287
INVESTIGATORS.  WE HAVE DOCTORS 

1890
01:15:24,287 --> 01:15:28,591
OLIVER BOWING HER.  OH, OKAY.  

1891
01:15:28,591 --> 01:15:31,194
WE -- OH, I'M SORRY, NEXT WE 

1892
01:15:31,194 --> 01:15:32,896
HAVE THE LEGISLATIVE REPORT FROM

1893
01:15:32,896 --> 01:15:35,765
MK.  SORRY ABOUT THAT MK.

1894
01:15:35,765 --> 01:15:36,599
>> THANK YOU FOR THE
OPPORTUNITY

1895
01:15:36,599 --> 01:15:39,969
TO SPEAK WITH YOU TODAY.  IN 

1896
01:15:39,969 --> 01:15:42,272
THE -- SO AFTER THAT 

1897
01:15:42,272 --> 01:15:44,707
PRESENTATION, I THINK WHAT YOU 

1898
01:15:44,707 --> 01:15:45,942
PROBABLY WANT TO KNOW FROM ME IS

1899
01:15:45,942 --> 01:15:47,744
WHAT ARE WE GOING TO GET FROM 

1900
01:15:47,744 --> 01:15:51,047
OUR APPROPRIATION FY25 AND WHEN?

1901
01:15:51,047 --> 01:15:55,051
I CAN'T GIVE YOU AERT OF  -- 

1902
01:15:55,051 --> 01:15:56,019
EITHER OF THOSE ANSWERS BUT I 

1903
01:15:56,019 --> 01:15:59,789
CAN PROVIDE CONTEXT ABOUT THE 

1904
01:15:59,789 --> 01:16:00,890
POLITICAL REPORTING YOU'RE GOING

1905
01:16:00,890 --> 01:16:03,326
TO HEAR INCESSANTLY FOR THE NEXT

1906
01:16:03,326 --> 01:16:04,461
COUPLE OF MONTHS.  THERE'S AN 

1907
01:16:04,461 --> 01:16:06,429
UPDATE IN YOUR MATERIALS AS I 

1908
01:16:06,429 --> 01:16:07,964
ALWAYS SAY.  I WILL BE BRIEF 

1909
01:16:07,964 --> 01:16:09,566
TODAY BUT IF YOU HAVE QUESTIONS 

1910
01:16:09,566 --> 01:16:11,201
OR WANT TO GET IN TOUCH WITH ME 

1911
01:16:11,201 --> 01:16:12,335
OR YOUR STAFF WE'RE ALWAYS HAPPY

1912
01:16:12,335 --> 01:16:14,070
TO HEAR FROM YOU AND ENGAGE WITH

1913
01:16:14,070 --> 01:16:15,371
OUR BOARDS AND RESEARCH 

1914
01:16:15,371 --> 01:16:19,042
INSTITUTIONS.  NEXT SLIDE, 

1915
01:16:19,042 --> 01:16:19,976
PLEASE.  SO THESE ARE THINGS I'M

1916
01:16:19,976 --> 01:16:21,344
GOING TO TALK ABOUT TODAY.  I'M 

1917
01:16:21,344 --> 01:16:25,248
GOING TO TOUCH ON FY25, THE 

1918
01:16:25,248 --> 01:16:26,683
CONGRESSIONAL CALENDAR.  

1919
01:16:26,683 --> 01:16:27,917
LEGISLATIVE ISSUES THAT CONGRESS

1920
01:16:27,917 --> 01:16:29,519
ALSO HAS TO DEAL WITH AND TOUCH 

1921
01:16:29,519 --> 01:16:32,489
ON THE IMPORTANCE OF ENGAGEMENT,

1922
01:16:32,489 --> 01:16:36,025
ADVOCACY AND HIGHLIGHT SOME OF 

1923
01:16:36,025 --> 01:16:38,194
THE DETAILS THAT DR. RATHMELL 

1924
01:16:38,194 --> 01:16:40,763
HAVE PARTICIPATED IN.  THE 

1925
01:16:40,763 --> 01:16:41,998
SPOILER ALERT IS THAT ANYONE OF 

1926
01:16:41,998 --> 01:16:43,867
THESE ARE GOING TO BE EASY NO 

1927
01:16:43,867 --> 01:16:44,834
MATTER WHAT THE ELECTION 

1928
01:16:44,834 --> 01:16:46,936
OUTCOMES THE BUDGET IS GOING TO 

1929
01:16:46,936 --> 01:16:48,505
BE QUITE DIFFICULT.  NEXT SLIDE,

1930
01:16:48,505 --> 01:16:50,773
PLEASE.  THERE'S A LOT OF 

1931
01:16:50,773 --> 01:16:52,876
REASONS FOR THAT AND I'LL DO IT.

1932
01:16:52,876 --> 01:16:54,244
NEVER MIND.  I'M SO USED TO 

1933
01:16:54,244 --> 01:16:55,545
DOING NEXT SLIDE.  PLEASE, 

1934
01:16:55,545 --> 01:16:57,647
EXCUSE ME.  I GOT VERY MUCH IN 

1935
01:16:57,647 --> 01:17:00,350
THE REMOTE PRESENTATION MODE.  

1936
01:17:00,350 --> 01:17:03,119
SO FY25 APPROPRIATIONS.  THE 

1937
01:17:03,119 --> 01:17:04,888
GOVERNMENT RUNS OUT OF FUNDING 

1938
01:17:04,888 --> 01:17:15,064
IN 26 DAYS.  FOR FY25, WHAT WE 

1939
01:17:15,064 --> 01:17:18,301
EXPECT IS THERE'S GOING TO BE A 

1940
01:17:18,301 --> 01:17:19,536
CR, A CONTINUING RESOLUTION 

1941
01:17:19,536 --> 01:17:21,604
UNTIL THE NEXT ELECTION.  WE 

1942
01:17:21,604 --> 01:17:23,139
DON'T KNOW HOW LONG IT'LL BE.  

1943
01:17:23,139 --> 01:17:24,841
JUST BECAUSE IT'S INEVITABLE 

1944
01:17:24,841 --> 01:17:26,142
DOESN'T MEAN IT'LL BE WITHOUT 

1945
01:17:26,142 --> 01:17:27,577
DRAMA.  JUST ON MONDAY, SPEAKER 

1946
01:17:27,577 --> 01:17:30,213
MIKE JOHNSON ANNOUNCED THAT HE 

1947
01:17:30,213 --> 01:17:31,781
WAS GOING TO ADVANCE SIX MONTHS 

1948
01:17:31,781 --> 01:17:33,783
CR GOING INTO MARCH THAT WOULD 

1949
01:17:33,783 --> 01:17:34,417
ALSO HAVE ATTACHED TO IT 

1950
01:17:34,417 --> 01:17:37,287
SOMETHING CALLED THE SAVE ACT 

1951
01:17:37,287 --> 01:17:39,155
WHICH IS SOMETHING ABOUT 

1952
01:17:39,155 --> 01:17:41,190
SAFEGUARDING VOTING RIGHTS.  IT 

1953
01:17:41,190 --> 01:17:44,127
WOULD PROHIBIT NONCITIZENS FROM 

1954
01:17:44,127 --> 01:17:45,595
VOTING IN FEDERAL ELECTIONS 

1955
01:17:45,595 --> 01:17:46,863
WHICH YOU MAY GUESS IS ALREADY 

1956
01:17:46,863 --> 01:17:49,432
ILLEGAL BUT THIS IS A MESSAGING 

1957
01:17:49,432 --> 01:17:52,135
BILL, IT PASSED THE HOUSE IN THE

1958
01:17:52,135 --> 01:17:54,103
SUMMER.  THERE IS A LOT OF 

1959
01:17:54,103 --> 01:17:55,672
OPPOSITION TO THIS APPROACH FOR 

1960
01:17:55,672 --> 01:17:59,042
MANY, MANY REASONS.  PUNTING 

1961
01:17:59,042 --> 01:18:00,443
APPROPRIATIONS INTO MARCH WOULD 

1962
01:18:00,443 --> 01:18:03,780
HAVE THE 119TH CONGRESS DECIDE 

1963
01:18:03,780 --> 01:18:05,448
APPROPRIATION.  OBVIOUSLY THE 

1964
01:18:05,448 --> 01:18:06,449
ELECTIONS, WE KNOW WE'RE GOING 

1965
01:18:06,449 --> 01:18:08,551
TO HAVE A NEW PRESIDENT AND NEW 

1966
01:18:08,551 --> 01:18:09,819
LEADERSHIP FOR SENATE 

1967
01:18:09,819 --> 01:18:11,487
REPUBLICANS SO WE DON'T KNOW 

1968
01:18:11,487 --> 01:18:12,889
WHETHER MAJORITIES WILL FLIP AND

1969
01:18:12,889 --> 01:18:14,357
THERE'LL BE OTHER CHANGES TO 

1970
01:18:14,357 --> 01:18:16,826
LEADERSHIP WHEN MAJORITIES DO 

1971
01:18:16,826 --> 01:18:19,629
CHANGE THE OUTGOING MAJORITY HAS

1972
01:18:19,629 --> 01:18:22,131
A REAL INTEREST IN GETTING WORK 

1973
01:18:22,131 --> 01:18:24,300
DONE DURING THE LAME DUCK THAT'S

1974
01:18:24,300 --> 01:18:25,668
WHAT THEY HAVE THE OPPORTUNITY. 

1975
01:18:25,668 --> 01:18:27,203
WILL THE LAME DUCK CONGRESS BE 

1976
01:18:27,203 --> 01:18:28,471
ABLE TO COMPLETE THE BILLS? 

1977
01:18:28,471 --> 01:18:31,774
WE'RE GOING TO COME BACK TO 

1978
01:18:31,774 --> 01:18:33,376
THAT.  I DON'T THINK WE WOULD --

1979
01:18:33,376 --> 01:18:34,477
I WOULDN'T BET THE HOUSE ON IT 

1980
01:18:34,477 --> 01:18:36,312
BUT IT'S GOING TO BE A CHALLENGE

1981
01:18:36,312 --> 01:18:37,947
AND THERE'S GOING TO BE A LOT OF

1982
01:18:37,947 --> 01:18:42,485
EFFORT TO DO THAT.  SO HERE'S 

1983
01:18:42,485 --> 01:18:44,153
WHERE THE APPROPRIATIONS 

1984
01:18:44,153 --> 01:18:45,788
COMMITTEE ENDED UP WITH THEIR 

1985
01:18:45,788 --> 01:18:48,491
MARKS ON NIH.  FOR THE HOUSE THE

1986
01:18:48,491 --> 01:18:49,892
TOP LINE THAT THEY STARTED WITH 

1987
01:18:49,892 --> 01:18:52,462
IS BELOW THE FY24 ENACTED LEVELS

1988
01:18:52,462 --> 01:18:54,097
WE'RE DEALING WITH YOU.  YOU 

1989
01:18:54,097 --> 01:18:55,298
PROBABLY REMEMBER THERE WAS A 

1990
01:18:55,298 --> 01:18:56,599
LOT OF DRAMA WITH THE HOUSE 

1991
01:18:56,599 --> 01:18:58,201
WANTING TO GO WITH NOT THE 

1992
01:18:58,201 --> 01:19:00,136
FISCAL RESPONSIBILITY ACT TOTALS

1993
01:19:00,136 --> 01:19:01,137
AND SIDE DEALS THAT WERE AGREED 

1994
01:19:01,137 --> 01:19:04,741
TO IN JUNE OF 2023. .  THEY 

1995
01:19:04,741 --> 01:19:05,942
WANTED TO PROCEED WITH A LOWER 

1996
01:19:05,942 --> 01:19:06,309
LEVEL. 

1997
01:19:06,309 --> 01:19:08,878
THAT CREATED AN ENORMOUS AMOUNT 

1998
01:19:08,878 --> 01:19:11,080
OF PROBLEMS FROM A BUDGET 

1999
01:19:11,080 --> 01:19:12,482
PERSPECTIVE.  WE ARE STILL UNDER

2000
01:19:12,482 --> 01:19:14,684
BUDGET CAPS FROM THE FISCAL 

2001
01:19:14,684 --> 01:19:17,520
RESPONSIBILITY ACT.  FY25 THE 

2002
01:19:17,520 --> 01:19:19,789
TOPLINE IS 1% ABOVE WHAT 

2003
01:19:19,789 --> 01:19:22,625
CONGRESS WAS ABLE TO SPEND IN 

2004
01:19:22,625 --> 01:19:24,894
FY24 BUT THIS IS STILL A PRETTY 

2005
01:19:24,894 --> 01:19:29,432
AUSTERE BUDGET PROPOSAL.  THE 

2006
01:19:29,432 --> 01:19:32,869
HOUSE PROPOSES FLAT FUNDING AND 

2007
01:19:32,869 --> 01:19:36,506
DON'T GET EXCITED 261 MILLION 

2008
01:19:36,506 --> 01:19:40,643
INCREASE.  IT CUTS A BILLION 

2009
01:19:40,643 --> 01:19:45,148
FROM ARPA-H AND THIS WAS VOTED 

2010
01:19:45,148 --> 01:19:47,016
OUT.  THE PROPOSED INCREASE IS 

2011
01:19:47,016 --> 01:19:48,785
SO LARGE AND VERY NICE TO SEE 

2012
01:19:48,785 --> 01:19:50,620
BUT IT -- THEY INCORPORATED WHAT

2013
01:19:50,620 --> 01:19:54,190
WE'RE GOING TO TOUCH ON LATER, 

2014
01:19:54,190 --> 01:19:55,825
THE HOUSE IS RESTRUCTURING 

2015
01:19:55,825 --> 01:19:58,261
REFORM OF NI H AND THAT 

2016
01:19:58,261 --> 01:20:02,065
CONSOLIDATED MANY INSTITUTES 

2017
01:20:02,065 --> 01:20:04,834
FROM 27 TO 15.  

2018
01:20:04,834 --> 01:20:06,402
THERE WERE BUDGETARY 

2019
01:20:06,402 --> 01:20:07,737
ADJUSTMENTS.  THERE IS A LIST OF

2020
01:20:07,737 --> 01:20:08,871
ACTIVITIES THAT HAVE PRICE TAGS 

2021
01:20:08,871 --> 01:20:11,741
ON THEM AS WELL IN THIS BILL BUT

2022
01:20:11,741 --> 01:20:12,909
IT STILL WOULD BE A SUBSTANTIAL 

2023
01:20:12,909 --> 01:20:15,978
INCREASE BUT THAT IS NOT GOING 

2024
01:20:15,978 --> 01:20:19,048
TO HAPPEN AS WRITTEN.  SO KEEP 

2025
01:20:19,048 --> 01:20:22,318
THAT IN MIND.  THAT IS BASED ON 

2026
01:20:22,318 --> 01:20:24,387
IMPORTANT MESSAGING FOR HOUSE 

2027
01:20:24,387 --> 01:20:25,421
REPUBLICANS BUT NOT THEIR PLAN 

2028
01:20:25,421 --> 01:20:28,191
TO MOVE FORWARD.  THE SENATE 

2029
01:20:28,191 --> 01:20:32,261
CAME IN WITH A TOP LINE WITHIN 

2030
01:20:32,261 --> 01:20:34,397
THE BUDGET CAPS BUT ALSO WITH 

2031
01:20:34,397 --> 01:20:37,834
THE SIDE DEALS THAT PROPOSED -- 

2032
01:20:37,834 --> 01:20:38,601
SLIGHTLY OVER 2 BILLION DOLLAR 

2033
01:20:38,601 --> 01:20:42,538
INCREASE FOR NIH AND FOR 266 

2034
01:20:42,538 --> 01:20:44,874
INCREASE FOR NCI THAT RESTORES 

2035
01:20:44,874 --> 01:20:47,343
THE MOON SHOT FUNDING GAP.  IS 

2036
01:20:47,343 --> 01:20:48,878
THAT AS THAT FUNDING STREAM 

2037
01:20:48,878 --> 01:20:50,546
ENDED WE HAD THAT DEFICIT AND 

2038
01:20:50,546 --> 01:20:52,148
ALSO GIVES US A 50 MILLION 

2039
01:20:52,148 --> 01:20:55,084
DOLLAR INCREASE.  A PROSED FLAT 

2040
01:20:55,084 --> 01:20:59,922
FUNDING FOR ARPA-H THIS WAS A 

2041
01:20:59,922 --> 01:21:03,726
BIPARTISAN BILL 25-3.  THE MORE 

2042
01:21:03,726 --> 01:21:04,894
BIPARTISAN THE BILL IS THE 

2043
01:21:04,894 --> 01:21:06,262
BETTER CHANCE OF GETTING DONE.  

2044
01:21:06,262 --> 01:21:16,806
I JUST WANT TO TAKE A MOMENT TO 

2045
01:21:19,709 --> 01:21:20,877
REMIND OURSELVES THAT THERE ARE 

2046
01:21:20,877 --> 01:21:24,514
GROWING PAINS WITH ALL OF THIS. 

2047
01:21:24,514 --> 01:21:25,081
WE HAVE STRONG BIPARTISAN 

2048
01:21:25,081 --> 01:21:26,649
SUPPORT FOR CANCER RESEARCH.  

2049
01:21:26,649 --> 01:21:28,017
THERE ARE A LOT OF REASONS FOR 

2050
01:21:28,017 --> 01:21:30,353
THIS.  WE HAVE REALLY BENEFITTED

2051
01:21:30,353 --> 01:21:31,721
FROM TREMENDOUS ENGAGEMENT FROM 

2052
01:21:31,721 --> 01:21:35,124
NOT ONLY THE NIH AND THE NCI BUT

2053
01:21:35,124 --> 01:21:36,626
ALSO THE RESEARCH COMMUNITY, 

2054
01:21:36,626 --> 01:21:40,863
PATIENT ADVOCATES, ASSOCIATIONS,

2055
01:21:40,863 --> 01:21:41,497
UNIVERSITIES, THESE ARE REALLY 

2056
01:21:41,497 --> 01:21:44,801
IMPORTANT OPPORTUNITIES THESE 

2057
01:21:44,801 --> 01:21:47,170
TWO SENIOR APPROPRIATORS ARE 

2058
01:21:47,170 --> 01:21:48,604
JUST EXAMPLES.  THEY ARE BY NO 

2059
01:21:48,604 --> 01:21:50,706
MEANS ALONE.  AND I THINK YOU 

2060
01:21:50,706 --> 01:21:53,009
ALL KNOW THIS FROM YOUR OWN 

2061
01:21:53,009 --> 01:21:56,145
CONGRESSIONAL ENGAGEMENT WORKING

2062
01:21:56,145 --> 01:21:57,413
WITH THE DELEGATIONS IN YOUR 

2063
01:21:57,413 --> 01:21:59,015
STATES TELLING THE STORIES OF 

2064
01:21:59,015 --> 01:22:00,583
RESEARCH IS INCREDIBLY IMPORTANT

2065
01:22:00,583 --> 01:22:01,684
AND THAT IS WHAT PEOPLE 

2066
01:22:01,684 --> 01:22:04,921
REMEMBER.  WHEN THEY WALK AWAY 

2067
01:22:04,921 --> 01:22:10,493
IT.  THE CONGRESSIONAL CALENDAR 

2068
01:22:10,493 --> 01:22:13,062
IS GOING TO BE QUITE DIFFICULT. 

2069
01:22:13,062 --> 01:22:19,535
CONGRESS HAS BEEN OUT FOR THE 

2070
01:22:19,535 --> 01:22:22,205
AUGUST RECESS AND WILL BE BACK 

2071
01:22:22,205 --> 01:22:24,373
NEXT WEEK.  THEY HAVE THE VOTE 

2072
01:22:24,373 --> 01:22:25,208
ON THE STOPGAP RESOLUTION.  

2073
01:22:25,208 --> 01:22:27,043
THERE'S THE FARM BILL, FLOOD 

2074
01:22:27,043 --> 01:22:28,845
INSURANCE, WE'LL SEE WHAT WILL 

2075
01:22:28,845 --> 01:22:32,882
HAPPEN THERE.  MAJORITY LEADER 

2076
01:22:32,882 --> 01:22:36,252
CHUCK SHCHUMER IN THE SENATE IS 

2077
01:22:36,252 --> 01:22:44,894
DETERMINED TO BRING UP AI.  HE 

2078
01:22:44,894 --> 01:22:47,063
WANTS TO MOVE SOMETHING ABOUT 

2079
01:22:47,063 --> 01:22:48,397
DEEPFAKES THE MOST CONTINUING 

2080
01:22:48,397 --> 01:22:50,132
THING THEY'LL DO IS THE 

2081
01:22:50,132 --> 01:22:51,367
CONTINUING RESOLUTION.  WE DON'T

2082
01:22:51,367 --> 01:22:52,869
KNOW HOW LONG IT'S GOING TO BE 

2083
01:22:52,869 --> 01:22:54,871
FOR.  NOT WITHOUT DRAMA.  THEN 

2084
01:22:54,871 --> 01:22:56,873
THEY LEAVE.  THEN OCTOBER 1ST, 

2085
01:22:56,873 --> 01:23:00,610
OUR FISCAL YEAR BEGINS I THINK 

2086
01:23:00,610 --> 01:23:05,214
MOST THE TRADITIONAL PLAY WOULD 

2087
01:23:05,214 --> 01:23:09,585
BE TO PUT A CR IN DECEMBER.  

2088
01:23:09,585 --> 01:23:12,655
START THE LAME DUCK CONGRESS 

2089
01:23:12,655 --> 01:23:15,358
SESSION WHICH BEGINS ON NOVEMBER

2090
01:23:15,358 --> 01:23:17,393
12TH AND THEN THEY HAVE TO BRING

2091
01:23:17,393 --> 01:23:20,863
IN A STOPGAP OR DECIDE ON 

2092
01:23:20,863 --> 01:23:22,031
APPROPRIATIONS.  THERE'S TWELVE 

2093
01:23:22,031 --> 01:23:23,499
DIFFERENT BILLS THAT HAVE TO BE 

2094
01:23:23,499 --> 01:23:24,834
DONE WHETHER THEY GET DONE IN 

2095
01:23:24,834 --> 01:23:28,037
THE LAME DUCK WE'LL RETURN TO 

2096
01:23:28,037 --> 01:23:30,306
THAT.  SO ANOTHER THING THAT 

2097
01:23:30,306 --> 01:23:32,074
HAPPENS, IT'S NOT GOING TO BE A 

2098
01:23:32,074 --> 01:23:33,342
GREAT HOLIDAY SEASON FOR A LOT 

2099
01:23:33,342 --> 01:23:35,444
OF CONGRESSIONAL STAFF THAT'S 

2100
01:23:35,444 --> 01:23:39,482
FOR SURE.  ON JANUARY 2ND THE 

2101
01:23:39,482 --> 01:23:43,786
DEBT LIMIT EXTENSION EXPIRES, 

2102
01:23:43,786 --> 01:23:44,887
THAT FISCAL RESPONSIBILITY ACT 

2103
01:23:44,887 --> 01:23:47,290
SET BUDGET GAPS AND SET THE DEBT

2104
01:23:47,290 --> 01:23:49,992
LIMIT UNTIL AFTER THIS ELECTION.

2105
01:23:49,992 --> 01:23:53,496
SO DEBT LIMIT SUSPENSIONS, THEY 

2106
01:23:53,496 --> 01:23:56,399
CAN EITHER BE SUSPENDED OR 

2107
01:23:56,399 --> 01:23:59,335
RAISED.  CONGRESS HAS DEFAULTED 

2108
01:23:59,335 --> 01:24:01,003
TO SUSPENSION RECENTLY THAT 

2109
01:24:01,003 --> 01:24:02,371
GIVES MORE ROOM BECAUSE THERE'S 

2110
01:24:02,371 --> 01:24:05,474
FACTORS OF WHEN YOU WILL HIT A 

2111
01:24:05,474 --> 01:24:08,544
DEBT LIMIT.  THIS IS THE FIRST 

2112
01:24:08,544 --> 01:24:10,012
THING THE LAME DUCK CONGRESS 

2113
01:24:10,012 --> 01:24:11,647
WILL GRAPPLE WITH.  THE TREASURY

2114
01:24:11,647 --> 01:24:15,451
WILL TAKE WHAT THEY CALL 

2115
01:24:15,451 --> 01:24:16,886
EXTRAORDINARY MEASURES FROM THE 

2116
01:24:16,886 --> 01:24:21,223
AS SOON AS THE DEBT LIMIT 

2117
01:24:21,223 --> 01:24:24,260
EXSPIRES THEY'RE GOING TO HAVE 

2118
01:24:24,260 --> 01:24:28,864
TO THIS BE A PRIORITY.  THEY'LL 

2119
01:24:28,864 --> 01:24:32,335
HAVE TO HAVE SOME PLANS FOR THE 

2120
01:24:32,335 --> 01:24:32,902
INAUGURATION OF THE NEXT 

2121
01:24:32,902 --> 01:24:34,537
PRESIDENT THAT IS OFTEN A 

2122
01:24:34,537 --> 01:24:37,440
TRIGGER FOR BUDGET DEALS.  

2123
01:24:37,440 --> 01:24:39,208
THERE ARE ALSO A SERIES OF 

2124
01:24:39,208 --> 01:24:40,476
PIECES OF LEGISLATION THAT HAVE 

2125
01:24:40,476 --> 01:24:42,712
TO BE DONE BY THE END OF 

2126
01:24:42,712 --> 01:24:45,481
DECEMBER.  THE NATIONAL DEFENSE 

2127
01:24:45,481 --> 01:24:46,482
AUTHORIZATION ACT.  THERE'S 

2128
01:24:46,482 --> 01:24:48,284
EMERGENCY FUNDING PROVISIONS, 

2129
01:24:48,284 --> 01:24:49,819
THERE'S A LOT OF ECONOMIC 

2130
01:24:49,819 --> 01:24:50,820
PRESSURES THAT WILL BE BROUGHT 

2131
01:24:50,820 --> 01:24:51,954
TO BEAR IN DECEMBER SO THIS IS 

2132
01:24:51,954 --> 01:24:54,724
GOING TO BE A TIME TO REALLY 

2133
01:24:54,724 --> 01:24:56,659
WATCH AND THIS IS GOING TO BE 

2134
01:24:56,659 --> 01:24:58,394
DOMINATING A LOT OF CONGRESS'S 

2135
01:24:58,394 --> 01:24:59,762
ATTENTION AT THAT TIME.  THE DAY

2136
01:24:59,762 --> 01:25:04,100
AFTER THE SUSPENSION, THE 119TH 

2137
01:25:04,100 --> 01:25:05,401
CONGRESS CONVENES, THE NEW 

2138
01:25:05,401 --> 01:25:08,871
MEMBERS WILL BE SWORN IN.  NEXT 

2139
01:25:08,871 --> 01:25:13,042
SLIDE, PLEASE.  I HAD COFFEE 

2140
01:25:13,042 --> 01:25:15,778
TAKE INTO CONSIDERATION I SWEAR.

2141
01:25:15,778 --> 01:25:16,812
2024 ELECTIONS.  ALL I'M GOING 

2142
01:25:16,812 --> 01:25:17,980
TO SAY ABOUT THIS IS WE KNOW 

2143
01:25:17,980 --> 01:25:20,916
THERE'S A LOT OF TOSSUPS IN THE 

2144
01:25:20,916 --> 01:25:23,753
AIR HERE.  THE POLITICAL REPORT 

2145
01:25:23,753 --> 01:25:26,689
IS AS GOOD A RESOURCE AS THERE 

2146
01:25:26,689 --> 01:25:27,823
IS.  I DON'T KNOW WHAT'S GOING 

2147
01:25:27,823 --> 01:25:30,993
TO HAPPEN.  NEITHER DO ANY OF US

2148
01:25:30,993 --> 01:25:33,496
BUT THEY'RE WRITING THE 

2149
01:25:33,496 --> 01:25:36,265
ELECTORAL COLLEGE AS A TOSSUP IN

2150
01:25:36,265 --> 01:25:38,667
THE HOUSE.  THEY'RE RATING 24 

2151
01:25:38,667 --> 01:25:42,071
SEATS AS A TOSSUP.  THAT GIVES 

2152
01:25:42,071 --> 01:25:43,606
DEMOCRATS AN OPPORTUNITY TO FLIP

2153
01:25:43,606 --> 01:25:45,674
THAT CHAMBER AND ARE SOMETHING 

2154
01:25:45,674 --> 01:25:47,643
THEY ARE HOPING TO DO.  THE 

2155
01:25:47,643 --> 01:25:51,047
SENATE THERE'S A MAJORITY AS 

2156
01:25:51,047 --> 01:25:54,817
WELL.  DEMS HAVE TO DEFEND A LOT

2157
01:25:54,817 --> 01:25:56,452
OF SWEETS. 

2158
01:25:56,452 --> 01:25:58,154
23 OF THE 34 THAT ARE OPEN THIS 

2159
01:25:58,154 --> 01:25:59,522
YEAR AND THE SENATE WORKS -- 

2160
01:25:59,522 --> 01:26:00,923
THERE'S THREE CLASSES IN THE 

2161
01:26:00,923 --> 01:26:02,625
SENATE AND THEY ARE STAGGERED 

2162
01:26:02,625 --> 01:26:04,193
AND WHEN THEY'RE UP FOR 

2163
01:26:04,193 --> 01:26:05,494
REELECTION WHEREAS THE HOUSE IS 

2164
01:26:05,494 --> 01:26:06,796
ALL UP AT THE SAME TIME EVERY 

2165
01:26:06,796 --> 01:26:07,763
TWO YEARS.  YOU CAN REALLY WHEN 

2166
01:26:07,763 --> 01:26:08,964
YOU THINK ABOUT THAT IT REALLY 

2167
01:26:08,964 --> 01:26:10,633
DOES HELP YOU UNDERSTAND THE 

2168
01:26:10,633 --> 01:26:11,567
HUGELY DIFFERENT CULTURE OF THE 

2169
01:26:11,567 --> 01:26:16,872
WAY THE HOUSE AND THE SENATE 

2170
01:26:16,872 --> 01:26:19,809
OPERATE.  BECAUSE WHEN YOU HAVE 

2171
01:26:19,809 --> 01:26:21,377
SIX YEARS THAT'S A DIFFERENT WAY

2172
01:26:21,377 --> 01:26:23,079
TO APPROACH A LEADERSHIP 

2173
01:26:23,079 --> 01:26:24,513
SITUATION AND A DIFFERENT 

2174
01:26:24,513 --> 01:26:25,981
THRESHOLD FOR FUNDRAISING WHAT 

2175
01:26:25,981 --> 01:26:28,084
WE'RE LOOKING AT IN THE SENATE 

2176
01:26:28,084 --> 01:26:32,121
IS DEMS DEFENDING WAY FOR SEATS 

2177
01:26:32,121 --> 01:26:34,290
THAN REPUBLICANS.  3 SEATS IS A 

2178
01:26:34,290 --> 01:26:34,557
TOSSUP. 

2179
01:26:34,557 --> 01:26:37,693
SO THERE IS A POSSIBILITY AND 

2180
01:26:37,693 --> 01:26:39,395
THEY KNOW THAT SENATOR MANCHIN'S

2181
01:26:39,395 --> 01:26:40,863
WEST VIRGINIA SEAT IS GOING TO 

2182
01:26:40,863 --> 01:26:42,798
BE REPUBLICAN VICTOR THERE.  SO 

2183
01:26:42,798 --> 01:26:48,804
THE REPUBLICANS ARE LOOKING AT 

2184
01:26:48,804 --> 01:26:51,407
THEIR FLIP OF THE SENATE.  THIS 

2185
01:26:51,407 --> 01:26:56,879
WILL FLIP IN 2026.  REPUBLICANS 

2186
01:26:56,879 --> 01:27:00,049
WILL BE DEFENDING 13 SEATS.  UP 

2187
01:27:00,049 --> 01:27:04,453
IN 2026.  SO THINGS CAN CHANGE 

2188
01:27:04,453 --> 01:27:06,122
IN TERMS OF PEOPLE RESIGNING OR 

2189
01:27:06,122 --> 01:27:08,891
LEAVING CONGRESS BUT THAT'S WHAT

2190
01:27:08,891 --> 01:27:11,093
IT LOOKS LIKE NOW.  SO BACK, I 

2191
01:27:11,093 --> 01:27:14,263
SAID WE WOULD COME BACK TO THE 

2192
01:27:14,263 --> 01:27:15,598
LAME DUCK CONGRESS AND WHETHER 

2193
01:27:15,598 --> 01:27:16,232
THEY WOULD GET THESE SPENDING 

2194
01:27:16,232 --> 01:27:20,035
BILLS DONE.  I JUST LOOKED HERE 

2195
01:27:20,035 --> 01:27:21,137
FOR THE PAST FOUR LAME DUCK 

2196
01:27:21,137 --> 01:27:23,339
CONGRESS'S TO SEE WHAT THEY'VE 

2197
01:27:23,339 --> 01:27:24,039
DONE.  STARTING WITH THE 

2198
01:27:24,039 --> 01:27:26,942
NORTHEAST RECENT FIRST.  THE 

2199
01:27:26,942 --> 01:27:28,711
REPUBLICANS FLIP THE HOUSE.  

2200
01:27:28,711 --> 01:27:30,846
THEY PUNTED ALL THE SPENDING 

2201
01:27:30,846 --> 01:27:31,947
BILLS UNTIL THE NEXT CONGRESS 

2202
01:27:31,947 --> 01:27:33,949
AND THEY WERE FINALLY ENACTED ON

2203
01:27:33,949 --> 01:27:35,918
MARCH 15TH.  NOT THE LATEST 

2204
01:27:35,918 --> 01:27:37,887
WE'VE GOTTEN OUR FUNDING BUT 

2205
01:27:37,887 --> 01:27:39,155
FAIRLY DEEP INTO THE FISCAL 

2206
01:27:39,155 --> 01:27:42,791
YEAR.  IN 2020 DEMS SPLIT SPLIT 

2207
01:27:42,791 --> 01:27:46,061
THE WHITE HOUSE AND THE SENATE. 

2208
01:27:46,061 --> 01:27:46,996
THE OMNIBUS PASSED IN DECEMBER. 

2209
01:27:46,996 --> 01:27:52,701
IN 2018 THE DEMS FLIPPED THE THE

2210
01:27:52,701 --> 01:27:54,870
HOUSE.  SOME BILLS WERE DONE ON 

2211
01:27:54,870 --> 01:27:59,208
TIME INCLUDING OURS AND THAT WAS

2212
01:27:59,208 --> 01:28:00,876
A WONDERFUL YEAR.  WE GOT OUR 

2213
01:28:00,876 --> 01:28:02,244
APPROPRIATION ON TIME.  THAT WAS

2214
01:28:02,244 --> 01:28:06,549
THE FIRST TIME SINCE 1996 THAT 

2215
01:28:06,549 --> 01:28:07,917
IT HAPPENED.  AND THEY WERE SHUT

2216
01:28:07,917 --> 01:28:13,389
DOWN FOR 39 DAYS.  SEVEN 

2217
01:28:13,389 --> 01:28:18,661
SPENDING BILLS WERE MOVED TO 

2218
01:28:18,661 --> 01:28:23,265
FEBRUARY.  THE LAME DUCK 

2219
01:28:23,265 --> 01:28:24,867
CONGRESS PASSED THE FIRST CURES 

2220
01:28:24,867 --> 01:28:26,936
BILL.  AND THEN WE DIDN'T GET 

2221
01:28:26,936 --> 01:28:28,871
APPROPRIATION UNTIL MAY 5TH.  IT

2222
01:28:28,871 --> 01:28:32,374
IS POSSIBLE TO REALLY PREDICT 

2223
01:28:32,374 --> 01:28:35,578
THE MAJORITY -- IF THERE ARE 

2224
01:28:35,578 --> 01:28:37,780
MAJORITY CHANGES THAT WILL 

2225
01:28:37,780 --> 01:28:48,324
AFFECT THE LAME DUCK CONGRESSE 

2226
01:28:51,093 --> 01:28:52,895
CONVERSATIONS AND SO MEMBERS ARE

2227
01:28:52,895 --> 01:28:54,129
GOING TO HAVE TO, AND THE 

2228
01:28:54,129 --> 01:28:59,034
LEADERSHIP IS GOING TO HAVE TO 

2229
01:28:59,034 --> 01:28:59,668
AT SOME POINT MAKE  STRATEGIC 

2230
01:28:59,668 --> 01:29:01,604
DECISION IN HOW THEY'RE GOING TO

2231
01:29:01,604 --> 01:29:07,676
PUSH AND ROLL OVER INTO THE NEXT

2232
01:29:07,676 --> 01:29:08,444
CONGRESS.  IT'S GOING IS TO BE A

2233
01:29:08,444 --> 01:29:11,981
BIG CHALLENGE FOR THEM.  SOME OF

2234
01:29:11,981 --> 01:29:14,717
THE LATEST LEGISLATIVE THINGS TO

2235
01:29:14,717 --> 01:29:16,485
WATCH ARE THE CONTINUING 

2236
01:29:16,485 --> 01:29:17,953
RESOLUTION, THE FARM BILL, FLOOD

2237
01:29:17,953 --> 01:29:20,889
INSURANCE, THERE'S ALSO A 

2238
01:29:20,889 --> 01:29:22,891
MEDICAID HEALTH EXTENDERS BILL. 

2239
01:29:22,891 --> 01:29:24,860
AND THE TEMPORARY ASSISTANCE FOR

2240
01:29:24,860 --> 01:29:26,362
NEEDING FAMILIES BILL.  ONE 

2241
01:29:26,362 --> 01:29:27,830
THING ABOUT THE EXTENDERS BILL I

2242
01:29:27,830 --> 01:29:31,567
WANTED TO MENTION, HUMANLY 

2243
01:29:31,567 --> 01:29:32,201
SUPPORTED, BIPARTISAN SUPPORT 

2244
01:29:32,201 --> 01:29:36,605
THERE THAT IS CERTAIN LY GOING O

2245
01:29:36,605 --> 01:29:39,041
MOVE AND WHEN YOU HAVE ANYTHING 

2246
01:29:39,041 --> 01:29:40,876
MOVING IT'S AN OPPORTUNITY FOR 

2247
01:29:40,876 --> 01:29:42,911
MANY OTHER BILLS AND THESE ARE 

2248
01:29:42,911 --> 01:29:43,712
TOPICS WHERE THERE'S LEGISLATION

2249
01:29:43,712 --> 01:29:45,614
THAT MAY PASS.  THINGS LIKE A 

2250
01:29:45,614 --> 01:29:48,050
VARIETY OF AI TYPES OF 

2251
01:29:48,050 --> 01:29:49,752
PROVISIONS.  TELEHEALTH 

2252
01:29:49,752 --> 01:29:51,587
EXTENSIONS.  THERE'S BEEN A LOT 

2253
01:29:51,587 --> 01:29:52,254
OF INTEREST IN CONGRESS TO WORK 

2254
01:29:52,254 --> 01:29:55,524
ON DRUG SHORTAGES, IMPROVING 

2255
01:29:55,524 --> 01:29:58,294
CLINICAL TRIALS AND THEN THERE'S

2256
01:29:58,294 --> 01:30:03,866
I THINK THIS IS UNLIKELY TO PASS

2257
01:30:03,866 --> 01:30:05,868
THE NIH SPECIFIC LEGISLATION.  

2258
01:30:05,868 --> 01:30:08,304
THE NIH REFORMATION ACT.  THIS 

2259
01:30:08,304 --> 01:30:10,172
WAS PUT OUT NOT AS A BILL BUT AS

2260
01:30:10,172 --> 01:30:12,941
A FRAMEWORK BY THE HOUSE OF 

2261
01:30:12,941 --> 01:30:18,914
ENERGY AND XHOCOMMERCE COMMITTE 

2262
01:30:18,914 --> 01:30:21,583
CATHY MCMORRIS ROGERS IS LEAVING

2263
01:30:21,583 --> 01:30:22,918
CONGRESS AFTER IS THIS SESSION. 

2264
01:30:22,918 --> 01:30:24,920
SHE'S RETIRING. 

2265
01:30:24,920 --> 01:30:27,323
AND SO THIS PLAN WOULD 

2266
01:30:27,323 --> 01:30:30,426
CONSOLIDATE 27 INSTITUTES AND 

2267
01:30:30,426 --> 01:30:32,361
CENTER TO 15.  NCI WOULD NOT BE 

2268
01:30:32,361 --> 01:30:34,530
PART OF THE CONSOLIDATION.  

2269
01:30:34,530 --> 01:30:36,799
CALLS FOR A COMMISSION TO REVIEW

2270
01:30:36,799 --> 01:30:40,336
NIH.  A LOT OF THIS IS DUE TO 

2271
01:30:40,336 --> 01:30:42,338
SOME TRANSPARENCY CONCERNS, SOME

2272
01:30:42,338 --> 01:30:43,272
COMMUNICATIONS ISSUES AND A LOT 

2273
01:30:43,272 --> 01:30:46,742
OF IT IS A POST-COVID ASSESSMENT

2274
01:30:46,742 --> 01:30:50,346
OF SOME CONGRESSIONAL 

2275
01:30:50,346 --> 01:30:50,979
DISSATISFACTION TYPICALLY IN 

2276
01:30:50,979 --> 01:30:52,915
HOUSE REPUBLICAN COMMUNITIES BUT

2277
01:30:52,915 --> 01:30:55,050
THERE ARE ALWAYS 

2278
01:30:55,050 --> 01:30:56,885
REAUTHORIZATIONS AT AGENCIES 

2279
01:30:56,885 --> 01:31:00,055
THAT ARE PERIODIC.  SOMETIMES 

2280
01:31:00,055 --> 01:31:02,257
BECAUSE IT EXPIRES.  WE JUST 

2281
01:31:02,257 --> 01:31:04,860
CONTINUE OUR WORK.  THE LAST 

2282
01:31:04,860 --> 01:31:08,864
MAJOR REAUTHORIZATION OF NIH WAS

2283
01:31:08,864 --> 01:31:14,169
IN 2006 SO THIS LEGISLATION IS 

2284
01:31:14,169 --> 01:31:16,038
THROWING OUT A LOT OF IDEAS, IN 

2285
01:31:16,038 --> 01:31:18,807
FACT, THEY DO CALL FOR 

2286
01:31:18,807 --> 01:31:23,379
TRANSPARENCY REGARDING INDIRECT 

2287
01:31:23,379 --> 01:31:24,279
COSTS.  WHICH ARE TRANSPARENT 

2288
01:31:24,279 --> 01:31:25,414
BECAUSE YOU CAN SEE WHAT ARE 

2289
01:31:25,414 --> 01:31:28,350
DIRECT COSTS AND WHAT WHERE NOT 

2290
01:31:28,350 --> 01:31:30,853
AND WE DO NOT DECIDE THOSE AND I

2291
01:31:30,853 --> 01:31:34,957
CAN TELL YOU WHEN THERE WAS AN 

2292
01:31:34,957 --> 01:31:41,296
EFFORT TO REALLY SHRINK INDIRECT

2293
01:31:41,296 --> 01:31:43,098
COST THERE WAS LANGUAGE THAT 

2294
01:31:43,098 --> 01:31:44,266
PROHIBITED CONSIDERATION OF 

2295
01:31:44,266 --> 01:31:45,768
INDIRECT COSTS BY THE AGENCY.  

2296
01:31:45,768 --> 01:31:48,871
SO THAT IS ABSOLUTELY A FIGHT 

2297
01:31:48,871 --> 01:31:51,707
THAT'S GOING TO BE A 

2298
01:31:51,707 --> 01:31:52,374
UNIVERSITIES AND CONGRESS FIGHT.

2299
01:31:52,374 --> 01:31:54,009
SO THIS IS SOMETHING THAT IS 

2300
01:31:54,009 --> 01:31:56,044
PROBABLY GOING TO GET MORE 

2301
01:31:56,044 --> 01:31:57,880
DISCUSSION.  THE -- BUT THIS IS 

2302
01:31:57,880 --> 01:31:59,715
THE REASON WHY THE HOUSE NUMBERS

2303
01:31:59,715 --> 01:32:02,451
IN THEIR PROPOSED BILL ARE NOT 

2304
01:32:02,451 --> 01:32:03,519
REPRESENTATIVE OF WHAT WE THINK 

2305
01:32:03,519 --> 01:32:06,054
MIGHT HAPPEN.  JUST A WORD ABOUT

2306
01:32:06,054 --> 01:32:07,322
CONGRESSIONAL ENGAGEMENT.  THIS 

2307
01:32:07,322 --> 01:32:10,559
IS INCREDIBLY IMPORTANT FOR MANY

2308
01:32:10,559 --> 01:32:12,895
REASONS.  DR. RATHMELL HAS MET 

2309
01:32:12,895 --> 01:32:14,797
WITH MANY MEMBERS OF CONGRESS 

2310
01:32:14,797 --> 01:32:20,202
AND WE HAVE MANY MORE FOR HER TO

2311
01:32:20,202 --> 01:32:25,040
MEET WITH.  SHE WENT TO A 

2312
01:32:25,040 --> 01:32:31,013
NATIONAL BRAIN TUMOR SOCIETY.  A

2313
01:32:31,013 --> 01:32:32,848
SENATOR WHO WAS A TREMENDOUS 

2314
01:32:32,848 --> 01:32:37,586
BEAST -- BOOSTER.  AND WHEN SHE 

2315
01:32:37,586 --> 01:32:40,355
WAS IN CHICAGO SHE HAD A CHANCE 

2316
01:32:40,355 --> 01:32:45,527
TO MEET WITH ANOTHER SENATOR.  

2317
01:32:45,527 --> 01:32:47,162
THESE ARE VERY, VERY MEANINGFUL 

2318
01:32:47,162 --> 01:32:49,765
TO THE MEMBERS NOT ONLY THE 

2319
01:32:49,765 --> 01:32:52,434
GEOGRAPHIC IMPACT OF HAVING 

2320
01:32:52,434 --> 01:32:54,503
CANCER CENTERS AND SPORE 

2321
01:32:54,503 --> 01:32:56,238
PROGRAMS.  BUT ALSO THE ECONOMIC

2322
01:32:56,238 --> 01:32:58,807
IMPACT OF NCI INVESTMENTS AND 

2323
01:32:58,807 --> 01:33:00,642
NIH FUNDING IS VERY IMPORTANT TO

2324
01:33:00,642 --> 01:33:03,111
THESE MEMBERS.  BUT ALSO, YOU 

2325
01:33:03,111 --> 01:33:04,413
KNOW, THIS IS PERSONAL.  ONE IN 

2326
01:33:04,413 --> 01:33:07,182
TWO MEN AND ONE IN THREE WOMEN 

2327
01:33:07,182 --> 01:33:08,150
GETTING CANCER IN THEIR LIFETIME

2328
01:33:08,150 --> 01:33:10,018
IS PERSONAL FOR ALL OF US IN 

2329
01:33:10,018 --> 01:33:11,086
DIFFERENT POINTS OF OUR LIVES 

2330
01:33:11,086 --> 01:33:12,721
AND SO THIS IS VERY MEANINGFUL 

2331
01:33:12,721 --> 01:33:14,122
AND SHARING THE STORIES OF YOUR 

2332
01:33:14,122 --> 01:33:15,090
OWN RESEARCH.  SHARING THE 

2333
01:33:15,090 --> 01:33:17,759
STORIES OF YOUR OWN EXPERIENCES,

2334
01:33:17,759 --> 01:33:19,061
THERE'S REALLY -- IT'S 

2335
01:33:19,061 --> 01:33:21,029
IMPOSSIBLE TO OVERESTIMATE THE 

2336
01:33:21,029 --> 01:33:22,130
IMPORTANCE OF THIS AND WE THANK 

2337
01:33:22,130 --> 01:33:24,132
YOU FOR ALL THE THINGS YOU DO IN

2338
01:33:24,132 --> 01:33:25,634
THAT REGARD AND TALKING ABOUT 

2339
01:33:25,634 --> 01:33:29,838
YOUR SCIENCE AND JOINING US IN 

2340
01:33:29,838 --> 01:33:31,340
ADVANCE THAT HIGHLIGHTS THOSE 

2341
01:33:31,340 --> 01:33:32,174
EXCITING OPPORTUNITIES.  THANK 

2342
01:33:32,174 --> 01:33:33,475
YOU FOR YOUR TIME IF THERE'S ANY

2343
01:33:33,475 --> 01:33:40,649
TIME FOR QUESTIONS, DR. CART 

2344
01:33:40,649 --> 01:33:40,816
PEN.

2345
01:33:40,816 --> 01:33:44,653
>> FANTASTIC PRESENTATION.

2346
01:33:44,653 --> 01:33:47,422
GIVEN THE GRAVITY OF THE 

2347
01:33:47,422 --> 01:33:48,924
UPCOMING MONTHS WE'RE GOING TO 

2348
01:33:48,924 --> 01:33:50,692
FOREGO QUESTIONS BUT IF ANYONE 

2349
01:33:50,692 --> 01:33:54,196
HAS A QUESTION FOR MK PLEASE 

2350
01:33:54,196 --> 01:33:58,467
SEND IT TO PAULETTE.  THANKS, 

2351
01:33:58,467 --> 01:34:09,011
AGAIN, FANTASTIC.  NEXT WE HAVE 

2352
01:34:16,285 --> 01:34:18,120
DR. RATHMELL.

2353
01:34:18,120 --> 01:34:20,923
>> WE HAVE ONE MEMBER IN 

2354
01:34:20,923 --> 01:34:22,925
ATTENDANCE TODAY RETIRING.  COME

2355
01:34:22,925 --> 01:34:24,927
ON UP HERE.  THE MEMBERSHIP OF 

2356
01:34:24,927 --> 01:34:27,396
THIS COUNCIL, THIS BOARD REALLY 

2357
01:34:27,396 --> 01:34:29,431
IMPACTS EVERYTHING THAT WE DO 

2358
01:34:29,431 --> 01:34:32,901
AND YOUR INSIGHTS ARE INCREDIBLY

2359
01:34:32,901 --> 01:34:35,804
VALUABLE.  JUST TO ACKNOWLEDGE 

2360
01:34:35,804 --> 01:34:39,641
SUSAN WHO HAS BROUGHT SO MANY 

2361
01:34:39,641 --> 01:34:41,877
INSIGHTS IN BEHAVIORAL HEALTH 

2362
01:34:41,877 --> 01:34:44,313
AND EPIDEMIOLOGY AND PUBLIC 

2363
01:34:44,313 --> 01:34:47,182
HEALTH SO FROM THE CANCER CENTER

2364
01:34:47,182 --> 01:34:48,050
WE HAVE APPRECIATED EVERYTHING 

2365
01:34:48,050 --> 01:34:50,052
YOU HAVE DONE AND SAID AND 

2366
01:34:50,052 --> 01:34:52,921
PUSHED US ON AND THANK YOU VERY 

2367
01:34:52,921 --> 01:34:54,523
MUCH.  SO IN HONOR WE HAVE A 

2368
01:34:54,523 --> 01:34:55,724
LOVELY PLAQUE FOR YOU.

2369
01:34:55,724 --> 01:35:06,001
>> (APPLAUSE).

2370
01:35:25,821 --> 01:35:27,990
>> ALL RIGHT, DR. BARKER,
WE 

2371
01:35:27,990 --> 01:35:30,158
HAVE TO THANK ANN BARKER WHO HAS

2372
01:35:30,158 --> 01:35:32,494
JOINED US FROM THE UNIVERSITY OF

2373
01:35:32,494 --> 01:35:34,429
CALIFORNIA.  I WAS TRYING TO 

2374
01:35:34,429 --> 01:35:36,898
THINK ABOUT WHAT TO SAY THAT 

2375
01:35:36,898 --> 01:35:37,833
KIND OF ENCAPSULATES ALL THE 

2376
01:35:37,833 --> 01:35:40,202
THINGS THAT SHE CONTRIBUTES TO 

2377
01:35:40,202 --> 01:35:40,869
BUT IT'S LITERALLY EVERYTHING.  

2378
01:35:40,869 --> 01:35:42,437
EVERYTHING THAT'S COMPLICATED.  

2379
01:35:42,437 --> 01:35:43,672
EVERYTHING THAT IS PARTICULARLY 

2380
01:35:43,672 --> 01:35:49,578
HARD I THINK OF AS DR. BARKER'S 

2381
01:35:49,578 --> 01:35:50,178
SPECIALTY BUT GLOBAL TEAM 

2382
01:35:50,178 --> 01:35:52,514
SCIENCE REALLY MAKING DATA 

2383
01:35:52,514 --> 01:35:55,083
ACCESSIBLE ARE REAL STRENGTHS 

2384
01:35:55,083 --> 01:35:56,785
AND, AGAIN, ALSO REAL COMMITMENT

2385
01:35:56,785 --> 01:35:58,954
TO THE NCI.  SO WE HAVE A PLAQUE

2386
01:35:58,954 --> 01:36:00,322
FOR YOU AS WELL.  IT'LL BE IN 

2387
01:36:00,322 --> 01:36:01,990
THE MAIL, THANK YOU VERY MUCH.

2388
01:36:01,990 --> 01:36:08,463
>> AUDIENCE: (APPLAUSE).

2389
01:36:08,463 --> 01:36:12,067
>> AND THEN WE HAVE TWO
OTHER 

2390
01:36:12,067 --> 01:36:16,872
RETIRING MEMBERS.  DR. N WAS ON 

2391
01:36:16,872 --> 01:36:19,374
BUT I THINK HAD TO LEAVE.  OKAY.

2392
01:36:19,374 --> 01:36:22,544
SO -- BUT AS CHIEF EXECUTIVE 

2393
01:36:22,544 --> 01:36:24,880
OFFICER AND MEDICAL DIRECTOR AT 

2394
01:36:24,880 --> 01:36:27,549
HEALTH CARE WITH FOCUS ON PAIN 

2395
01:36:27,549 --> 01:36:29,551
AND HAD REAL SUPPORT FROM THEM 

2396
01:36:29,551 --> 01:36:31,453
AND GLAD TO HAVE THAT SUPPORT.  

2397
01:36:31,453 --> 01:36:32,921
WE'LL SEND THAT AS WELL AND ALSO

2398
01:36:32,921 --> 01:36:35,957
BUT NOT ABLE TO ATTEND 

2399
01:36:35,957 --> 01:36:38,326
DR. HOWARD WHO BRINGS THE 

2400
01:36:38,326 --> 01:36:41,897
PATIENT CARE TRANSLATIONAL 

2401
01:36:41,897 --> 01:36:43,699
EXPERTISE FROM HIS ROLE AT 

2402
01:36:43,699 --> 01:36:45,267
PHARMA AND SO REALLY GRATEFUL 

2403
01:36:45,267 --> 01:36:52,107
FOR HIS SUPPORT AS WELL.  SO 

2404
01:36:52,107 --> 01:36:55,711
WITH FOUR RETIRING MEMBERS WE 

2405
01:36:55,711 --> 01:37:01,717
HAVE FOUR NEW MEMBERS.  WE HAVE 

2406
01:37:01,717 --> 01:37:02,918
ONE ONLINE.  AND WE HAVE THREE 

2407
01:37:02,918 --> 01:37:05,287
WITH US.  ALL PROVISIONAL RIGHT 

2408
01:37:05,287 --> 01:37:08,457
NOW BUT FAR ALONG THE PROCESS TO

2409
01:37:08,457 --> 01:37:10,992
ATTEND SO THERE'S KAREN.  VERY 

2410
01:37:10,992 --> 01:37:15,764
GOOD.  SO I WILL START WITH 

2411
01:37:15,764 --> 01:37:18,600
DR. EDMUNDS IS A PROFESSOR AT 

2412
01:37:18,600 --> 01:37:20,335
THE SCHOOL OF PUBLIC HEALTH.  

2413
01:37:20,335 --> 01:37:22,104
SHE HAS EXPERTISE IN CANCER 

2414
01:37:22,104 --> 01:37:25,707
EQUITY AND IMPLEMENTATION 

2415
01:37:25,707 --> 01:37:29,311
SCIENCE.  THE DOCTOR WORK'S IS 

2416
01:37:29,311 --> 01:37:34,149
FOCUSED ON CANCER PREVENTION IN 

2417
01:37:34,149 --> 01:37:35,083
DISADVANTAGED COMMUNITIES AND SO

2418
01:37:35,083 --> 01:37:36,918
WE'RE VERY GLAD TO HAVE YOU HERE

2419
01:37:36,918 --> 01:37:38,553
AND IN THE DISCUSSION.  REALLY 

2420
01:37:38,553 --> 01:37:42,657
IMPORTANT THAT YOU'RE ON OUR 

2421
01:37:42,657 --> 01:37:45,093
COMMITTEE.  TAMEKA.  I KNOW 

2422
01:37:45,093 --> 01:37:47,262
YOU'RE HERE.  THE CHIEF 

2423
01:37:47,262 --> 01:37:48,563
VISIONARY OF SURVIVOR.  SHE 

2424
01:37:48,563 --> 01:37:51,066
FOUNDED THIS ORGANIZATION IN 

2425
01:37:51,066 --> 01:37:53,034
2005 AFTER SURVIVING CERVICAL 

2426
01:37:53,034 --> 01:37:57,506
CANCER IN HER MID-20S AS A 

2427
01:37:57,506 --> 01:37:59,274
NONPROFIT SHE'S BEEN DISMANTLING

2428
01:37:59,274 --> 01:38:02,077
THE DISEASE STIGMA THROUGH THE 

2429
01:38:02,077 --> 01:38:05,514
RENOWNED SURVIVOR SCHOOL SHE'S 

2430
01:38:05,514 --> 01:38:08,917
ASKED PEOPLE TO SPEAK OUT.  THIS

2431
01:38:08,917 --> 01:38:10,685
INCLUDES THE PRESIDENTIAL 

2432
01:38:10,685 --> 01:38:14,322
RESEARCH AWARD AND FOR THE YOUNG

2433
01:38:14,322 --> 01:38:19,761
ADULT AWARD.  ALL RIGHT ALICIA 

2434
01:38:19,761 --> 01:38:21,496
CLARK.  SO DR. CLARK IS THE 

2435
01:38:21,496 --> 01:38:23,665
CHIEF OF THE DIVISION OF 

2436
01:38:23,665 --> 01:38:25,934
CERVICAL ONCOLOGY AND IN THE 

2437
01:38:25,934 --> 01:38:27,969
DEPARTMENT OF SURGERY AT THE 

2438
01:38:27,969 --> 01:38:31,740
MEDICAL COLLEGE IN WISCONSIN AND

2439
01:38:31,740 --> 01:38:37,045
IN EPIGENETIC TUMORS AND 

2440
01:38:37,045 --> 01:38:39,214
AMELIORATE CANCER DISPARITIES.  

2441
01:38:39,214 --> 01:38:42,884
HER M.D. RESIDENCY IN THE 

2442
01:38:42,884 --> 01:38:44,953
CINCINNATI COLLEGE OF MEDICINE 

2443
01:38:44,953 --> 01:38:48,523
AND SHE'S ELECTED TO THE AOA 

2444
01:38:48,523 --> 01:38:53,528
HONOR SOCIETY.  AND LAST.  THE 

2445
01:38:53,528 --> 01:38:56,898
DANIEL LOUIS ENDOWED CHAIR AND 

2446
01:38:56,898 --> 01:39:01,703
ASSOCIATE PROFESSOR AT THE EMERY

2447
01:39:01,703 --> 01:39:03,605
SCHOOL OF MEDICINE AND LEADS THE

2448
01:39:03,605 --> 01:39:08,443
BRAIN TUMORS INSTITUTE AND IS 

2449
01:39:08,443 --> 01:39:11,313
RENOWNED AS NEUROSURGICAL AND WE

2450
01:39:11,313 --> 01:39:13,648
GOT TO MEET AT THE BRAIN TUMOR 

2451
01:39:13,648 --> 01:39:15,250
FOUNDATION AND IS VERY ACTIVE IN

2452
01:39:15,250 --> 01:39:16,918
THAT COMMUNITY.  SO THANK YOU 

2453
01:39:16,918 --> 01:39:17,519
VERY MUCH.  SO THANK YOU.  SO 

2454
01:39:17,519 --> 01:39:27,963
WELCOME.  AND ON WITH THE WORK.

2455
01:39:27,963 --> 01:39:31,933
>> GREAT, THANKS, KIM.  SO
NOW, 

2456
01:39:31,933 --> 01:39:36,838
IT'S OUR PRESENTATION ON NCI 

2457
01:39:36,838 --> 01:39:39,140
SUPPORTIVE EARLY CAREER CANCER 

2458
01:39:39,140 --> 01:39:42,744
INVESTIGATORS BROUGHT TO US BY 

2459
01:39:42,744 --> 01:39:46,581
DR. BOWING HER, DR. DA HAVE A 

2460
01:39:46,581 --> 01:39:49,784
KNOW, WHO WORKS IN CANCER 

2461
01:39:49,784 --> 01:39:50,619
TRAINING.  A DEVELOP.  BRANCH 

2462
01:39:50,619 --> 01:39:52,921
WITHIN THE CENTER FOR CANCER 

2463
01:39:52,921 --> 01:39:54,556
TRAINING AND JESSICA CALENDAR 

2464
01:39:54,556 --> 01:39:58,793
ZOLA WHO IS A BRANCH DIRECTOR 

2465
01:39:58,793 --> 01:40:02,397
FOR BRANCH PROGRAMS, CENTER 

2466
01:40:02,397 --> 01:40:04,799
CANCER HEALTH EQUITIES.

2467
01:40:04,799 --> 01:40:05,567
>> THANK YOU FOR THE
OPPORTUNITY

2468
01:40:05,567 --> 01:40:09,604
TO TALK ABOUT TRAINING.  I WILL 

2469
01:40:09,604 --> 01:40:15,610
GIVE YOU THE SLIDES AND THEN 

2470
01:40:15,610 --> 01:40:17,712
HAND IT OVER TO MY COLLEAGUES.  

2471
01:40:17,712 --> 01:40:20,916
SO OF COURSE THE MISSION OF WHAT

2472
01:40:20,916 --> 01:40:24,986
WE DO BOTH IN OUR GROUPS IS 

2473
01:40:24,986 --> 01:40:26,288
DERIVED FROM THE WORKFORCE GOAL 

2474
01:40:26,288 --> 01:40:28,590
AND THE NCI GENERAL MISSION AND 

2475
01:40:28,590 --> 01:40:30,458
MY CENTER FOR CANCER TRAINING 

2476
01:40:30,458 --> 01:40:31,826
HAS THREE GROUPS.  ONE OF WHICH 

2477
01:40:31,826 --> 01:40:33,795
IS FOCUSED ON EXTRAMURAL WORK 

2478
01:40:33,795 --> 01:40:38,300
AND THEN WE HAVE TWO GROUPS 

2479
01:40:38,300 --> 01:40:39,234
FOCUSED ON INTRAMURAL WORK AND I

2480
01:40:39,234 --> 01:40:41,736
WILL MENTION ONE PIECE OF WORK 

2481
01:40:41,736 --> 01:40:43,338
THAT COMES FROM OUR PROGRAM AS 

2482
01:40:43,338 --> 01:40:46,708
WELL SO TOGETHER ACROSS THE NCI,

2483
01:40:46,708 --> 01:40:49,577
IN COLLABORATION WITH THE CENTER

2484
01:40:49,577 --> 01:40:52,747
FOR CANCER WE OFFER A VARIETY OF

2485
01:40:52,747 --> 01:40:54,082
MECHANISMS ACROSS THE EARLY 

2486
01:40:54,082 --> 01:40:55,383
STAGES OF THE CANCER-Y SIR 

2487
01:40:55,383 --> 01:40:58,687
CAREERS AS YOU CAN SEE HERE.  I 

2488
01:40:58,687 --> 01:40:59,854
DON'T HAVE TIME TO GO INTO ALL 

2489
01:40:59,854 --> 01:41:01,523
OF THEM.  I WILL TALK ABOUT THE 

2490
01:41:01,523 --> 01:41:04,259
CHANGE WE MADE RECENTLY AND A 

2491
01:41:04,259 --> 01:41:05,727
COUPLE OF THOSE MECHANISMS THAT 

2492
01:41:05,727 --> 01:41:08,897
WE HEARD FROM THE COMMUNITY TO 

2493
01:41:08,897 --> 01:41:10,865
IMPROVE OUR EFFORTS AS WE WORK 

2494
01:41:10,865 --> 01:41:14,769
WITH THE PEOPLE IN THIS ROOM AND

2495
01:41:14,769 --> 01:41:16,638
BEYOND.  ANOTHER WAY TO LOOK AT 

2496
01:41:16,638 --> 01:41:19,841
THE SNAPSHOT IS BY THE NUMBER OF

2497
01:41:19,841 --> 01:41:23,645
ACTIVE MECHANISMS AND THE DOLLAR

2498
01:41:23,645 --> 01:41:24,879
AMOUNT.  I HOPE YOU HAVE THE 

2499
01:41:24,879 --> 01:41:26,247
SLIDES IN YOUR FOLDERS.  YOU CAN

2500
01:41:26,247 --> 01:41:29,050
LOOK AT THEM AT YOUR LEISURE.  

2501
01:41:29,050 --> 01:41:29,918
THE KEY POINT I WANT TO MAKE 

2502
01:41:29,918 --> 01:41:30,719
SURE IS WE HAVE A LOT OF 

2503
01:41:30,719 --> 01:41:33,121
DIFFERENT INVESTMENTS.  SOME OF 

2504
01:41:33,121 --> 01:41:36,124
THESE ARE VERY NICHE.  OUR 

2505
01:41:36,124 --> 01:41:37,826
BIGGEST BUDGET ITEMS ARE THE KO 

2506
01:41:37,826 --> 01:41:41,196
8 AND THE T32 THOSE ARE OUR 

2507
01:41:41,196 --> 01:41:43,098
BIGGEST TRAINING MECHANISMS BY 

2508
01:41:43,098 --> 01:41:46,167
BOTH THE DOLLARS AND THE PEOPLE 

2509
01:41:46,167 --> 01:41:47,135
INVOLVED AND OF COURSE WE HAVE 

2510
01:41:47,135 --> 01:41:49,137
SOME MARQUEE TRANSITION AWARDS 

2511
01:41:49,137 --> 01:41:52,273
LIKE THE F99 AND I WILL TALK 

2512
01:41:52,273 --> 01:41:55,176
ABOUT THE 91 BRIEFLY IN A 

2513
01:41:55,176 --> 01:41:59,214
MOMENT.  I NEED TO PIVOT NOW TO 

2514
01:41:59,214 --> 01:42:03,785
THE CANCER TRAINING BRANCH SO 

2515
01:42:03,785 --> 01:42:04,919
THIS IS REALLY THE MOST 

2516
01:42:04,919 --> 01:42:06,654
IMPORTANT SLIDE IF YOU TAKE ONE 

2517
01:42:06,654 --> 01:42:08,656
THING AWAY FROM MY PRESENTATION 

2518
01:42:08,656 --> 01:42:10,358
IT IS THIS SLIDE WHICH REALLY 

2519
01:42:10,358 --> 01:42:12,627
SHOWS YOU WHAT DR. RATHMELL SIDE

2520
01:42:12,627 --> 01:42:15,497
EARLIER IN HER PRESENTATION.  

2521
01:42:15,497 --> 01:42:19,034
AND THIS CAN BE SEEN IN THE 

2522
01:42:19,034 --> 01:42:21,036
DOLLARS AND CENTS.  WE HAD A 5% 

2523
01:42:21,036 --> 01:42:23,538
INCREASE IN FUNDING.  WHICH 

2524
01:42:23,538 --> 01:42:24,506
GIVEN THE CONTEXT AND THE 

2525
01:42:24,506 --> 01:42:25,907
ENVIRONMENT IN WHICH WE'RE IN IS

2526
01:42:25,907 --> 01:42:27,976
A PHENOMENAL TESTAMENT TO 

2527
01:42:27,976 --> 01:42:29,844
DR. RATHMELL'S STRONG SUPPORT 

2528
01:42:29,844 --> 01:42:31,613
FOR EARLY CAREER INVESTIGATORS 

2529
01:42:31,613 --> 01:42:33,481
AND I AM VERY GRATEFUL FOR HER 

2530
01:42:33,481 --> 01:42:35,817
AS IS THE COMMUNITY AND THE 

2531
01:42:35,817 --> 01:42:36,918
TEAM.  THAT'S REALLY GREAT NEWS.

2532
01:42:36,918 --> 01:42:39,220
WE HAD MORE MONEY, WE -- WE WERE

2533
01:42:39,220 --> 01:42:40,922
ANTICIPATING ABOUT 210 MILLION 

2534
01:42:40,922 --> 01:42:43,024
OR SO IN THIS BUDGET WE DON'T 

2535
01:42:43,024 --> 01:42:45,560
HAVE THE FINAL '24 NUMBERS YET. 

2536
01:42:45,560 --> 01:42:51,366
WE'RE FINISHING OUT THE  YEAR.  

2537
01:42:51,366 --> 01:42:53,635
MOST OF THOSE FUNDS WENT TOWARDS

2538
01:42:53,635 --> 01:42:54,569
INFLATIONARY PRESSURES.  SO IT'S

2539
01:42:54,569 --> 01:42:56,037
NOT GOING TO BE REFLECTED IN THE

2540
01:42:56,037 --> 01:42:58,073
AMOUNT OF MONEY WE HAVE FOR NEW 

2541
01:42:58,073 --> 01:43:00,909
AWARDS.  NOW THE INFLATIONARY 

2542
01:43:00,909 --> 01:43:02,977
PRESSURES, WHAT'S INSIDE THEM IS

2543
01:43:02,977 --> 01:43:06,147
VERY IMPORTANT STUFF IS THE 

2544
01:43:06,147 --> 01:43:07,782
INCREASE IN STIPENDS AND SUPPORT

2545
01:43:07,782 --> 01:43:08,883
FOR OUR EARLY CAREER 

2546
01:43:08,883 --> 01:43:10,118
INVESTIGATORS, I'M NOT SAYING 

2547
01:43:10,118 --> 01:43:12,620
IT'S A BAD THING, IT'S JUST A 

2548
01:43:12,620 --> 01:43:13,254
REALITY AND OF COURSE WE HAVE 

2549
01:43:13,254 --> 01:43:15,323
THEREFORE INCREASED OUR FUNDING 

2550
01:43:15,323 --> 01:43:16,925
FOR SOME OF THE MECHANISM BUT IT

2551
01:43:16,925 --> 01:43:17,992
ISN'T NECESSARILY REFLECTED IN 

2552
01:43:17,992 --> 01:43:20,628
THE NUMBER OF NEW AWARDS THAT WE

2553
01:43:20,628 --> 01:43:21,930
WERE ABLE TO MEET THIS YEAR.  

2554
01:43:21,930 --> 01:43:23,665
THAT'S REALLY THE HEADLINE I'M 

2555
01:43:23,665 --> 01:43:25,633
GOING TO GIVE YOU THAT DEADLINE 

2556
01:43:25,633 --> 01:43:28,503
FOR KOA.  WE HAVE HAD A STEADY 

2557
01:43:28,503 --> 01:43:29,704
INCREASE OVER THE LAST SEVERAL 

2558
01:43:29,704 --> 01:43:31,172
YEARS IN THIS MECHANISM 

2559
01:43:31,172 --> 01:43:32,540
REFLECTING A STRONG COMMITMENT 

2560
01:43:32,540 --> 01:43:35,143
TO PHYSICIAN SCIENTISTS, WE 

2561
01:43:35,143 --> 01:43:37,011
ANTICIPATE MAKING 43 COMPETITIVE

2562
01:43:37,011 --> 01:43:40,915
AWARDS IN FISCAL 24 THAT NUMBER 

2563
01:43:40,915 --> 01:43:43,218
IS PERHAPS NOT FINAL WHICH IS ON

2564
01:43:43,218 --> 01:43:44,919
PAR WITH WHAT WE HAVE DONE IN 

2565
01:43:44,919 --> 01:43:46,521
RECENT YEARS AND REFLECTS AN 

2566
01:43:46,521 --> 01:43:48,022
INCREASE IN THE OVERALL 

2567
01:43:48,022 --> 01:43:51,059
MECHANISM.  THE T32S THE STORY 

2568
01:43:51,059 --> 01:43:52,894
IS WHAT SIMILAR.  WE'VE BEEN 

2569
01:43:52,894 --> 01:43:54,996
FLATTER BUT WE'RE ACTUALLY 

2570
01:43:54,996 --> 01:43:58,533
ANTICIPATING MAKING 32 ANY 

2571
01:43:58,533 --> 01:44:00,468
COMPETITIVE NEW AWARDS.  THEY'RE

2572
01:44:00,468 --> 01:44:03,271
NOT ALL NEW BUT A MAJORITY ARE 

2573
01:44:03,271 --> 01:44:06,307
RENEWALS WHICH COMPARES 

2574
01:44:06,307 --> 01:44:08,743
FAVORABLE.  WE DID HAVE A BUMPER

2575
01:44:08,743 --> 01:44:11,746
YEAR FOR '22 AND '23 BUT WE'RE 

2576
01:44:11,746 --> 01:44:12,881
ANTICIPATING MAKING A GOOD 

2577
01:44:12,881 --> 01:44:14,516
NUMBER OF AWARDS HERE.  WHAT 

2578
01:44:14,516 --> 01:44:16,317
DOES THAT LOOK LIKE IN TERMS OF 

2579
01:44:16,317 --> 01:44:18,219
SUCCESS RATES? THEY'RE ACTUALLY 

2580
01:44:18,219 --> 01:44:19,387
PRETTY GOOD.  WE HAD A QUESTION 

2581
01:44:19,387 --> 01:44:23,491
ABOUT WHAT IS THE SUCCESS RATE 

2582
01:44:23,491 --> 01:44:27,162
FOR 32S.  IT'S ABOUT 40%.  WHICH

2583
01:44:27,162 --> 01:44:29,697
WHEN YOU TALK ABOUT THE OTHER 

2584
01:44:29,697 --> 01:44:31,799
COLLEAGUES I'M PRETTY HAPPY 

2585
01:44:31,799 --> 01:44:33,334
ABOUT THAT.  WE'VE HAD GOOD 

2586
01:44:33,334 --> 01:44:35,703
NUMBERS ACROSS OUR MECHANISMS 

2587
01:44:35,703 --> 01:44:38,706
INCLUDING K 08 WHERE WE HAVE A 

2588
01:44:38,706 --> 01:44:40,508
25% SUCCESS RATE.  WE HAVE BEEN 

2589
01:44:40,508 --> 01:44:42,911
LOOKING A LITTLE BIT AT OUR 

2590
01:44:42,911 --> 01:44:47,348
EARLY FELLOWSHIP PORTFOLIOS.  

2591
01:44:47,348 --> 01:44:48,783
THE FUNDING RATE THERE IS NOT 

2592
01:44:48,783 --> 01:44:50,618
NEARLY SO HIGH.  I WANT TO ALSO 

2593
01:44:50,618 --> 01:44:52,020
SHOW YOU THIS SLIDE BECAUSE THE 

2594
01:44:52,020 --> 01:44:54,122
QUESTION I OFTEN GET ASKED IS 

2595
01:44:54,122 --> 01:44:56,024
WELL WHAT DO YOU DO FOR 

2596
01:44:56,024 --> 01:44:58,893
CLINICIAN INVESTIGATORS? THIS IS

2597
01:44:58,893 --> 01:45:00,929
ACTUALLY ALL THE DATA BUT WE DID

2598
01:45:00,929 --> 01:45:02,997
TAKE A SNAPSHOT AND WE DID 

2599
01:45:02,997 --> 01:45:04,699
SOMETHING SIMPLE WE COUNTED THE 

2600
01:45:04,699 --> 01:45:06,034
NUMBER OF PEOPLE SUPPORTED WHO 

2601
01:45:06,034 --> 01:45:08,036
HAVE A DEGREE RECOGNIZING THAT 

2602
01:45:08,036 --> 01:45:09,837
WE'RE MISSING SOME OF THE OTHER 

2603
01:45:09,837 --> 01:45:12,273
DEGREES AND SO ON AND AS YOU CAN

2604
01:45:12,273 --> 01:45:15,743
SEE, BY HEAD COUNT ACROSS OUR 

2605
01:45:15,743 --> 01:45:19,547
PORTFOLIO, 45% OF THE PEOPLE WHO

2606
01:45:19,547 --> 01:45:23,117
WE WERE SUPPORTING HAVE AN M.D. 

2607
01:45:23,117 --> 01:45:25,820
DEGREE.  THE AWARDING TEND TO 

2608
01:45:25,820 --> 01:45:28,223
HAVE SLIGHTLY HIGHER FUNDING 

2609
01:45:28,223 --> 01:45:31,392
VALUE.  YOU CAN SEE THE KOH AND 

2610
01:45:31,392 --> 01:45:34,696
ABOUT HALF OF THE T32 SLOTS THAT

2611
01:45:34,696 --> 01:45:37,265
WE HAVE GO TO PEOPLE WITH M.D.  

2612
01:45:37,265 --> 01:45:42,170
WE ARE FOCUSED ON SUPPORTING 

2613
01:45:42,170 --> 01:45:44,305
THIS VITAL COMMUNITY AND OTHERS 

2614
01:45:44,305 --> 01:45:46,274
I'M NOT ABLE TO TALK ABOUT TODAY

2615
01:45:46,274 --> 01:45:47,442
BUT WE CONTINUE TO TALK ABOUT 

2616
01:45:47,442 --> 01:45:48,776
THE COMMUNITY AND TRY TO LEARN 

2617
01:45:48,776 --> 01:45:51,112
HOW WE CAN DO BETTER.  LET ME 

2618
01:45:51,112 --> 01:45:52,347
TELL YOU ABOUT A THREE CHANGES 

2619
01:45:52,347 --> 01:45:54,482
THAT ARE COMING OR HAVE COME IN 

2620
01:45:54,482 --> 01:45:56,251
RECENT MONTHS THAT I THINK ARE 

2621
01:45:56,251 --> 01:45:57,819
REALLY SIGNIFICANT.  THE FIRST 

2622
01:45:57,819 --> 01:46:04,259
ONE IS A NEW KO 1.  THIS IS A 

2623
01:46:04,259 --> 01:46:06,027
SLIGHTLY DIFFERENT USE OF THE KO

2624
01:46:06,027 --> 01:46:08,062
1.  THIS ONE IS FOCUSED ON THE 

2625
01:46:08,062 --> 01:46:11,032
MISSION AREAS OF THE DIVISION OF

2626
01:46:11,032 --> 01:46:13,968
CANCER PREVENTION.  AND TOGETHER

2627
01:46:13,968 --> 01:46:16,337
WITH PHIL AND KATRINA'S TEAMS WE

2628
01:46:16,337 --> 01:46:18,239
WORKED ON THIS NEW MECHANISM.  

2629
01:46:18,239 --> 01:46:20,041
WE'RE BEGINNING TO SEE THE FIRST

2630
01:46:20,041 --> 01:46:21,509
NEW APPLICATIONS.  WE HAVEN'T 

2631
01:46:21,509 --> 01:46:23,678
HAD THAT MANY YET.  WE'RE VERY 

2632
01:46:23,678 --> 01:46:24,479
EXCITED ABOUT OFFERING THIS 

2633
01:46:24,479 --> 01:46:26,080
PARTICULAR AWARD FOR THIS 

2634
01:46:26,080 --> 01:46:28,016
CRITICAL COMMUNITY AND WE HAVE 

2635
01:46:28,016 --> 01:46:29,751
HOPED TO HAVE ENHANCED THE 

2636
01:46:29,751 --> 01:46:32,086
SUPPORT OF THE EARLY CAREER 

2637
01:46:32,086 --> 01:46:36,057
PATHWAYINGS S IN THOSE TWO 

2638
01:46:36,057 --> 01:46:37,692
MISSION AREAS. 

2639
01:46:37,692 --> 01:46:40,762
WE ALSO TOOK A DEEP DIVE ON THE 

2640
01:46:40,762 --> 01:46:49,037
R     EDDED  R 00. 

2641
01:46:49,037 --> 01:46:51,973
I WILL NOT TELL YOU THE WHOLE 

2642
01:46:51,973 --> 01:46:52,206
PAPER. 

2643
01:46:52,206 --> 01:46:54,309
LET ME TELL YOU TWO PIECES OF 

2644
01:46:54,309 --> 01:46:56,511
DATA.  THE FIRST IS THAT THESE 

2645
01:46:56,511 --> 01:46:57,912
AWARDEES DO TREMENDOUSLY WELL 

2646
01:46:57,912 --> 01:46:59,013
WHEN YOU LOOK AT THEIR 

2647
01:46:59,013 --> 01:47:00,915
DOWNSTREAM FUNDING RECORD.  AT 

2648
01:47:00,915 --> 01:47:02,216
THE TOP OF THE GRAPH WHAT YOU'RE

2649
01:47:02,216 --> 01:47:04,118
LOOKING AT IS IN THE RED BAR IS 

2650
01:47:04,118 --> 01:47:08,156
THE APPLICATIONS FOR R 01 

2651
01:47:08,156 --> 01:47:10,391
EQUIVALENTS AND IN THE GRAY BARS

2652
01:47:10,391 --> 01:47:13,995
THE AWARDS AND K99 AND 00 ALUMS 

2653
01:47:13,995 --> 01:47:18,599
ARE APPLYING AT 90% RATES AND 

2654
01:47:18,599 --> 01:47:22,337
GETTING AWARDS AT THE 65% RATE. 

2655
01:47:22,337 --> 01:47:25,173
IF YOU LOOK AT DISCUSSED BUT NOT

2656
01:47:25,173 --> 01:47:27,275
AWARDEDED.  THOSE NUMBERS 

2657
01:47:27,275 --> 01:47:28,676
DECLINE.  ONE OF THE REASONS 

2658
01:47:28,676 --> 01:47:31,546
WE'RE TAKING A GOOD LOOK AT OUR 

2659
01:47:31,546 --> 01:47:31,846
PORTFOLIO. 

2660
01:47:31,846 --> 01:47:33,214
THAT'S THE GOOD NEWS AND ALSO WE

2661
01:47:33,214 --> 01:47:35,249
KNOW FROM OUR DISCUSSION AND WE 

2662
01:47:35,249 --> 01:47:38,152
DID SOME INTERVIEWS, 95% OF 

2663
01:47:38,152 --> 01:47:39,287
THESE FOLKS TRANSITION TO 

2664
01:47:39,287 --> 01:47:40,988
INDEPENDENCE AND MANY OF THOSE 

2665
01:47:40,988 --> 01:47:44,158
WERE HELPFUL TO THEM IN THEIR 

2666
01:47:44,158 --> 01:47:46,761
QUEST FOR AN INDEPENDENT.  WHAT 

2667
01:47:46,761 --> 01:47:50,164
WE DID SOT SEE IS ACCELERATION, 

2668
01:47:50,164 --> 01:47:51,632
ONE OF THE PURPOSES OF THE 

2669
01:47:51,632 --> 01:47:55,069
ORIGINAL DESIGN WAS TO CELEBRATE

2670
01:47:55,069 --> 01:47:56,070
INDEPENDENCE.  BUT WHEN YOU LOOK

2671
01:47:56,070 --> 01:47:58,005
AT THE DESIGN AND THE EQUIVALENT

2672
01:47:58,005 --> 01:47:59,640
YOU CAN SEE THERE'S NO 

2673
01:47:59,640 --> 01:48:02,176
DIFFERENCE BETWEEN OUR K99 

2674
01:48:02,176 --> 01:48:05,847
AWARDEES AND THE THREE DIFFERENT

2675
01:48:05,847 --> 01:48:07,448
GROUPS.  I PERSONALLY THINK 

2676
01:48:07,448 --> 01:48:09,417
THAT'S BECAUSE THE WINDOW IS THE

2677
01:48:09,417 --> 01:48:11,152
MAIN DETERMINANT.  THE NUMBER IS

2678
01:48:11,152 --> 01:48:12,854
RIGHT AROUND TEN YEARS AND I 

2679
01:48:12,854 --> 01:48:14,689
THINK PEOPLE ARE TRYING TO MAKE 

2680
01:48:14,689 --> 01:48:16,090
THEIR FIRST APPLICATION AS LATE 

2681
01:48:16,090 --> 01:48:18,693
AS POSSIBLE WITHIN THE ESI 

2682
01:48:18,693 --> 01:48:20,395
WINDOW.  HAVING SEEN THAT, WE 

2683
01:48:20,395 --> 01:48:21,028
DECIDED TO MAKE A SIGNIFICANT 

2684
01:48:21,028 --> 01:48:23,598
CHANGE IN OUR K99 WHICH THE 

2685
01:48:23,598 --> 01:48:24,899
COMMUNITY'S BEEN URGING US TO DO

2686
01:48:24,899 --> 01:48:27,668
WHICH IS TO INCREASE THE 

2687
01:48:27,668 --> 01:48:28,870
APPLICATION ELIGIBILITY WINDOW 

2688
01:48:28,870 --> 01:48:30,772
FROM FOUR YEAR TO SIX YEARS THAT

2689
01:48:30,772 --> 01:48:33,307
MEANS THAT PEOPLE WHO HAVE 

2690
01:48:33,307 --> 01:48:34,275
FAMILIES DURING THEIR POSTDOC. 

2691
01:48:34,275 --> 01:48:35,710
WHO MIGHT BE WORKING ON A TYPE 

2692
01:48:35,710 --> 01:48:37,512
OF SCIENCE THAT REQUIRES A LONG 

2693
01:48:37,512 --> 01:48:39,046
LEAD TIME OFTEN MINORITIES WHO 

2694
01:48:39,046 --> 01:48:41,015
TAKE LONGER TO GET GOING THIS 

2695
01:48:41,015 --> 01:48:43,151
THEIR RESEARCH WILL HAVE A MORE 

2696
01:48:43,151 --> 01:48:43,785
OPPORTUNITY TO COMPETE BE FOR 

2697
01:48:43,785 --> 01:48:47,722
THIS AMAZING AWARD THAT HELPS 

2698
01:48:47,722 --> 01:48:48,022
PEOPLE. 

2699
01:48:48,022 --> 01:48:50,625
AND WE'RE WORKING ON A PROGRAM 

2700
01:48:50,625 --> 01:48:52,193
ANNOUNCEMENT THAT WE WILL SEE 

2701
01:48:52,193 --> 01:48:54,195
SOON THAT WILL INCREASE THE 

2702
01:48:54,195 --> 01:48:54,796
ELIGIBILITY FROM FOUR TO SIX 

2703
01:48:54,796 --> 01:48:58,533
YEARS.  AT THE SAME TIME WE'RE 

2704
01:48:58,533 --> 01:49:00,902
ALSO DOING SUNSET RK 22.  A LESS

2705
01:49:00,902 --> 01:49:03,204
GOOD VERSION OF THE K99.  IT 

2706
01:49:03,204 --> 01:49:05,706
GIVES YOU LESS MONEY, IT GIVES 

2707
01:49:05,706 --> 01:49:07,074
YOU LESS ATTRACTIVENESS IN THE 

2708
01:49:07,074 --> 01:49:08,910
MARKETPLACE IF YOU WILL AND IT 

2709
01:49:08,910 --> 01:49:10,878
HAS AN EIGHT YEAR ELIGIBILITY 

2710
01:49:10,878 --> 01:49:12,146
WINDOW.  SO SINCE WE NOW HAVE A 

2711
01:49:12,146 --> 01:49:13,881
SIX YEAR WITH THE K99 WE'RE 

2712
01:49:13,881 --> 01:49:16,851
GOING TO SUNSET THE K22 AND MOVE

2713
01:49:16,851 --> 01:49:18,986
THAT BUDGET INTO THE K99.  WE 

2714
01:49:18,986 --> 01:49:21,122
EXPECT MORE AWARDS COMING FOR 

2715
01:49:21,122 --> 01:49:23,925
THAT MECHANISM THE COMING YEARS.

2716
01:49:23,925 --> 01:49:28,896
ONE OF THE PRIORITIES THAT WAS 

2717
01:49:28,896 --> 01:49:36,537
SHARED.  I WANT TO TAKE ONE 

2718
01:49:36,537 --> 01:49:37,071
MINUTE TO TALK ABOUT THE 

2719
01:49:37,071 --> 01:49:40,007
INTRAMURAL PROGRAM.  OUR OFFICE 

2720
01:49:40,007 --> 01:49:44,712
LED BY GINSBURG HAS THE MARQUIS 

2721
01:49:44,712 --> 01:49:46,848
PROGRAMS.  AND WE HAVE THE 

2722
01:49:46,848 --> 01:49:49,584
FELLOWSHIP FOR SCIENTISTS AND 

2723
01:49:49,584 --> 01:49:51,319
EDUCATION.  WE CAN SHARE THE 

2724
01:49:51,319 --> 01:49:52,920
LINKS BUT THIS PAPER SHOWS YOU 

2725
01:49:52,920 --> 01:49:54,489
THAT THE LEADERSHIP TRAINING 

2726
01:49:54,489 --> 01:49:59,026
PROGRAM FOR OUR IN-HOUSE WOMEN 

2727
01:49:59,026 --> 01:49:59,727
POST-DOCTORAL SCIENTISTS IS 

2728
01:49:59,727 --> 01:50:01,629
EXTREMELY IMPACTFUL ON THEIR 

2729
01:50:01,629 --> 01:50:03,798
CAREERS, ON THEIR ABILITY TO GO 

2730
01:50:03,798 --> 01:50:05,833
OUT AND GET GREAT JOBS AND WE'RE

2731
01:50:05,833 --> 01:50:07,768
SUPER PROUD OF THEM.  I LIED, 

2732
01:50:07,768 --> 01:50:11,138
THERE'S ONE MORE SLIDE.  WE ALSO

2733
01:50:11,138 --> 01:50:12,340
THINK ABOUT PEOPLE OUTSIDE OF 

2734
01:50:12,340 --> 01:50:15,576
OUR IMMEDIATE CONTACTS.  OUTSIDE

2735
01:50:15,576 --> 01:50:17,445
OF THE INTRAMURAL RESEARCH 

2736
01:50:17,445 --> 01:50:18,946
PROGRAMS.  WE SUPPORT ABOUT A 

2737
01:50:18,946 --> 01:50:19,814
THOUSAND PEOPLE AND TOUCH ABOUT 

2738
01:50:19,814 --> 01:50:21,215
A THOUSAND PEOPLE THROUGH GRANTS

2739
01:50:21,215 --> 01:50:23,451
AND OTHER MECHANISMS.  THESE ARE

2740
01:50:23,451 --> 01:50:25,386
THE TWO PROGRAMS THAT WE 

2741
01:50:25,386 --> 01:50:27,188
LAUNCHED.  WE HAVE INSIDE CANCER

2742
01:50:27,188 --> 01:50:28,923
CAREERS WHERE WE TRY TO 

2743
01:50:28,923 --> 01:50:30,124
ILLUMINATE ALL THE DIFFERENT 

2744
01:50:30,124 --> 01:50:31,225
CAREERS AND ALSO AN ATTEMPT TO 

2745
01:50:31,225 --> 01:50:32,960
BRING PEOPLE EARLIER IN THEIR 

2746
01:50:32,960 --> 01:50:34,962
LIFE, PEOPLE IN HIGH SCHOOL AND 

2747
01:50:34,962 --> 01:50:37,365
UNDERGRADS INTO THIS WORLD.  AND

2748
01:50:37,365 --> 01:50:38,332
WE ARE -- WE HAVE LAUNCHED AND 

2749
01:50:38,332 --> 01:50:40,601
ARE NOW WORKING ON AN AI POWERED

2750
01:50:40,601 --> 01:50:43,738
APP THAT WILL -- THAT DOES HELP 

2751
01:50:43,738 --> 01:50:44,906
EARLY CAREER SCIENTISTS MANAGE 

2752
01:50:44,906 --> 01:50:46,340
THE LITERATURE AND MAKE SOCIAL 

2753
01:50:46,340 --> 01:50:48,442
CONNECTIONS AND I WILL NOW LIKE 

2754
01:50:48,442 --> 01:50:50,344
TO HAND OVER TO MY COLLEAGUES IN

2755
01:50:50,344 --> 01:50:54,015
THE CENTER FOR CANCER HEALTH 

2756
01:50:54,015 --> 01:51:04,492
EQUITY.  DR. DA HAVE A KNOW.

2757
01:51:06,761 --> 01:51:08,162
>> GOOD MORNING, EVERYONE,
I 

2758
01:51:08,162 --> 01:51:09,897
HAVE TO FIGURE OUT HOW TO 

2759
01:51:09,897 --> 01:51:10,531
ADVANCE THE SLIDES.  THE KEY 

2760
01:51:10,531 --> 01:51:12,934
BAR.  THANKS SO MUCH.  GOOD 

2761
01:51:12,934 --> 01:51:15,670
MORNING, EVERYONE, MY NAME IS 

2762
01:51:15,670 --> 01:51:17,805
DR. DA HAVE A KNOW AND TODAY IN 

2763
01:51:17,805 --> 01:51:20,708
THE SECOND PART OF THIS SESSION 

2764
01:51:20,708 --> 01:51:21,709
MY COLLEAGUE DR. CALENDAR ZOLA 

2765
01:51:21,709 --> 01:51:24,412
AND I WILL PROVIDE A BRIEF 

2766
01:51:24,412 --> 01:51:27,515
OVERVIEW OF THE PROGRAM AND 

2767
01:51:27,515 --> 01:51:33,721
INITIATIVES IN THE TRAINING AS 

2768
01:51:33,721 --> 01:51:41,329
SUPPORTED BY CCHES.  ONE OF 

2769
01:51:41,329 --> 01:51:47,068
IMPORTANT MISSIONS OF THE CCHES 

2770
01:51:47,068 --> 01:51:53,941
IS TO ADVANCE I CANNOT SEE THE 

2771
01:51:53,941 --> 01:51:55,076
SLIDES HERE.  ONE OF OUR 

2772
01:51:55,076 --> 01:51:56,811
MISSIONS IS TO PROMOTE DIVERSITY

2773
01:51:56,811 --> 01:51:59,046
IN THE CANCER WORKFORCEADVANCE  

2774
01:51:59,046 --> 01:51:59,680
HERE.  ONE OF OUR MISSIONS IS TO

2775
01:51:59,680 --> 01:52:00,314
PROMOTE DIVERSITY IN THE CANCER 

2776
01:52:00,314 --> 01:52:01,115
WORKFORCE.  IT'S NOT WORKING 

2777
01:52:01,115 --> 01:52:08,289
YET.  THE SLIDES, SO, ANYWAY, 

2778
01:52:08,289 --> 01:52:10,958
AND WE ACHIEVE THIS BY -- WE 

2779
01:52:10,958 --> 01:52:12,760
ACHIEVE THIS BY ATTRACTING 

2780
01:52:12,760 --> 01:52:14,462
TRAINING, NURTURING AND 

2781
01:52:14,462 --> 01:52:17,064
RETAINING TALENTED INDIVIDUALS 

2782
01:52:17,064 --> 01:52:18,499
FROM GROUPS UNDERREPRESENTED IN 

2783
01:52:18,499 --> 01:52:21,969
THE BIOMEDICAL SCIENCE.  OUR 

2784
01:52:21,969 --> 01:52:24,305
EFFORTS ARE ALIGNED WITH THE 

2785
01:52:24,305 --> 01:52:26,841
EMPOWERING ALL OF THE NATIONAL 

2786
01:52:26,841 --> 01:52:28,643
CANCER PLANS, OPTIMIZING THE 

2787
01:52:28,643 --> 01:52:32,013
WORKFORCE BY ENGAGING EVERY 

2788
01:52:32,013 --> 01:52:33,014
PERSON AND ELIMINATING 

2789
01:52:33,014 --> 01:52:43,057
INEQUALITYINGS -- INEQUALITIES. 

2790
01:52:43,057 --> 01:52:45,960
OUR FLAGSHIP PROGRAM IS THE CURE

2791
01:52:45,960 --> 01:52:48,663
PROGRAM THAT AIMS TO SUPPORT A 

2792
01:52:48,663 --> 01:52:52,266
CONTINUUM OF COMPETITIVE FUNDING

2793
01:52:52,266 --> 01:52:55,202
OPPORTUNITIES FOR INDIVIDUALS 

2794
01:52:55,202 --> 01:52:57,972
FROM MIDDLE SCHOOL THROUGH 

2795
01:52:57,972 --> 01:52:58,339
INVESTIGATORS. 

2796
01:52:58,339 --> 01:53:02,743
LAUNCHED AROUND 25 YEARS AGO, 

2797
01:53:02,743 --> 01:53:05,212
CURE HAS EVOLVED OVER THE YEARS 

2798
01:53:05,212 --> 01:53:06,814
AND INCLUDES BOTH INSTITUTIONAL 

2799
01:53:06,814 --> 01:53:08,449
AND INDIVIDUAL EFFORTS AS LISTED

2800
01:53:08,449 --> 01:53:13,921
IN THIS SLIDE.  CURE IS THE 

2801
01:53:13,921 --> 01:53:16,190
PROGRAM THAT GOES BEYOND THE 

2802
01:53:16,190 --> 01:53:17,625
FUNDING MECHANISM.  IT'S ABOUT 

2803
01:53:17,625 --> 01:53:20,428
CULTIVATING A CULTURE OF 

2804
01:53:20,428 --> 01:53:23,464
EXCELLENCE.  CREATING A PATHWAY 

2805
01:53:23,464 --> 01:53:26,534
FOR PROGRESS AND FOR A SENSE OF 

2806
01:53:26,534 --> 01:53:28,669
BELONGING AND COMMUNITY AMONG 

2807
01:53:28,669 --> 01:53:32,907
THE TRAINEES AND INVESTIGATORS. 

2808
01:53:32,907 --> 01:53:36,243
A HOLISTIC APPROACH INCLUDES 

2809
01:53:36,243 --> 01:53:37,044
ENHANCED PROFESSIONAL 

2810
01:53:37,044 --> 01:53:37,978
DEVELOPMENT OPPORTUNITIES SUCH 

2811
01:53:37,978 --> 01:53:41,649
AS MENTOR REVIEW, PROFESSIONAL 

2812
01:53:41,649 --> 01:53:46,187
WORKSHOPS, PEER MENTORING AND 

2813
01:53:46,187 --> 01:53:46,587
TRA

2814
01:53:46,587 --> 01:53:48,889
TRAINING NAVIGATIONS.  IN THE 

2815
01:53:48,889 --> 01:53:49,724
FOLLOWING SLIDESLY SHARE WITH 

2816
01:53:49,724 --> 01:53:52,193
YOU THE PURPOSE OF EACH 

2817
01:53:52,193 --> 01:53:54,328
MECHANISM WITHIN THE CURE 

2818
01:53:54,328 --> 01:53:55,963
PATHWAY AND TRENDS THAT WE HAVE 

2819
01:53:55,963 --> 01:54:04,505
SEEN IN THE LAST TEN YEARS.  THE

2820
01:54:04,505 --> 01:54:06,807
FIRST PROGRAM WITHIN THE CURE IS

2821
01:54:06,807 --> 01:54:09,810
PROGRAM TO PROMOTE DIVERSITY.  

2822
01:54:09,810 --> 01:54:13,280
THIS PROGRAMS ARE DESIGNED TO 

2823
01:54:13,280 --> 01:54:15,616
TRAIN AND DEVELOP THE CAREER 

2824
01:54:15,616 --> 01:54:16,283
DEVELOPMENT FOR INDIVIDUALS FROM

2825
01:54:16,283 --> 01:54:19,754
HIGH SCHOOL TO EARLIER STAGE 

2826
01:54:19,754 --> 01:54:21,222
INVESTIGATOR LEVELS.  THE 

2827
01:54:21,222 --> 01:54:24,892
SUPPLEMENTS OFTEN SERVE AS THE 

2828
01:54:24,892 --> 01:54:27,528
GATEWAY FOR INVESTIGATORS TO 

2829
01:54:27,528 --> 01:54:31,599
ENTER THE NCI RESEARCH 

2830
01:54:31,599 --> 01:54:32,266
COMMUNITY.  WHEN LOOKING AT THIS

2831
01:54:32,266 --> 01:54:36,570
SLIDE AND A FEW SLIDES THAT ARE 

2832
01:54:36,570 --> 01:54:38,339
COMING, NOTE THAT THE ACCESS ON 

2833
01:54:38,339 --> 01:54:41,542
THE LEFT SHOWS THE NUMBER OF 

2834
01:54:41,542 --> 01:54:45,746
INVOLVED AND THE AXIS ON THE 

2835
01:54:45,746 --> 01:54:47,882
RIGHT IS THE BUDGET.  THE BLACK 

2836
01:54:47,882 --> 01:54:48,916
LINE INDICATES THE NUMBER OF 

2837
01:54:48,916 --> 01:54:52,720
APPLICATIONS WE RECEIVED AND THE

2838
01:54:52,720 --> 01:54:54,622
RED LINE SHOWS WHAT WE HAVE 

2839
01:54:54,622 --> 01:54:55,923
MADE. 

2840
01:54:55,923 --> 01:54:59,126
AS SHOWN IN THIS SLIDE, IN THIS 

2841
01:54:59,126 --> 01:55:00,895
GRAPH, THE INTEREST HAS GROWN 

2842
01:55:00,895 --> 01:55:02,797
SIGNIFICANTLY.  THIS YEAR, WE 

2843
01:55:02,797 --> 01:55:09,069
RECEIVE 28ED 0 DIVERSE 

2844
01:55:09,069 --> 01:55:09,637
SUPPLEMENTS. 

2845
01:55:09,637 --> 01:55:13,774
THE NEXT PROGRAM WITHIN THE CURE

2846
01:55:13,774 --> 01:55:18,312
IS F31 DIVERSITY.  IS A 

2847
01:55:18,312 --> 01:55:19,413
FELLOWSHIP DEVELOPED TO SUPPORT 

2848
01:55:19,413 --> 01:55:23,117
TRAINING LEADING TO A PH.D. OR A

2849
01:55:23,117 --> 01:55:25,986
DUAL DEGREE AS AN M.D./PH.D. WE 

2850
01:55:25,986 --> 01:55:27,988
HAVE SEEN AN INCREASE IN THE 

2851
01:55:27,988 --> 01:55:34,228
NUMBER OF APPLICATIONS RECEIVED 

2852
01:55:34,228 --> 01:55:39,700
FROM 91 TO 103.  THE GREEN LINE 

2853
01:55:39,700 --> 01:55:41,702
HERE SHOWS THE APPLICATION 

2854
01:55:41,702 --> 01:55:44,738
RECEIVED THE HIGH SCORE 10-30 AS

2855
01:55:44,738 --> 01:55:46,240
YOU CAN SEE WE HAVE NOT BEEN 

2856
01:55:46,240 --> 01:55:49,844
ABLE TO SUPPORT ALL THE 

2857
01:55:49,844 --> 01:55:54,248
APPLICATIONS DUE TO THE BUDGET, 

2858
01:55:54,248 --> 01:55:57,484
THE FLAT BUDGETS.  THE CAREER 

2859
01:55:57,484 --> 01:56:00,654
DEVELOPMENT PORTFOLIO INCLUDES 

2860
01:56:00,654 --> 01:56:04,458
THREE MECHANISMS.  AGAIN, SINCE 

2861
01:56:04,458 --> 01:56:05,826
2015, IT HAS BEEN NEARLY AN 

2862
01:56:05,826 --> 01:56:10,698
INCREASE 21% IN THE NUMBER OF 

2863
01:56:10,698 --> 01:56:14,134
APPLICATION RECEIVED.  AND A 

2864
01:56:14,134 --> 01:56:17,571
RECENT PORTFOLIO ANALYZERS OF 

2865
01:56:17,571 --> 01:56:26,313
THIS PROGRAM SHOWS THAT 36% ARE 

2866
01:56:26,313 --> 01:56:28,916
WON AFTER ENDED.  MENTIONED THE 

2867
01:56:28,916 --> 01:56:31,085
HIGHEST INCREASE FOR THE K 

2868
01:56:31,085 --> 01:56:33,487
APPLICANT WAS THE K 08 WHICH IS 

2869
01:56:33,487 --> 01:56:34,889
FOR CLINICIAN SCIENTIST THAT 

2870
01:56:34,889 --> 01:56:37,491
SHOWS THE THE SIGNIFICANT GROWTH

2871
01:56:37,491 --> 01:56:40,561
IN THE PORTFOLIO. 

2872
01:56:40,561 --> 01:56:44,598
AND IT HAS BEEN WORKED SINCE 

2873
01:56:44,598 --> 01:56:46,934
2018.  THE CENTER ALSO SUPPORTS 

2874
01:56:46,934 --> 01:56:47,835
IN COLLABORATION WITH THE 

2875
01:56:47,835 --> 01:56:49,703
ADDITIONAL CANCER BIOLOGIC.  THE

2876
01:56:49,703 --> 01:56:57,778
PURPOSE OF THIS PROGRAM IS TO 

2877
01:56:57,778 --> 01:56:59,747
ASSIST AND HELP NEW 

2878
01:56:59,747 --> 01:57:00,814
INVESTIGATORS THAT MAY NEED 

2879
01:57:00,814 --> 01:57:03,384
EXTRA TIME OR SUPPORT TO DEVELOP

2880
01:57:03,384 --> 01:57:05,552
A LARGER RESEARCH PROJECT GRANT 

2881
01:57:05,552 --> 01:57:08,289
AS R 01.  

2882
01:57:08,289 --> 01:57:11,325
WE HAVE DECREASED THE NUMBER OF 

2883
01:57:11,325 --> 01:57:13,060
APPLICATIONS OVER THE YEARS AND 

2884
01:57:13,060 --> 01:57:16,163
IT IS PROBABLY DUE TO THE 

2885
01:57:16,163 --> 01:57:18,232
COMPETITIVE ENVIRONMENT AND 

2886
01:57:18,232 --> 01:57:19,900
STRINGENT PAY LINE WHICH IS 

2887
01:57:19,900 --> 01:57:22,236
AROUND 10 THIS YEAR OR LAST 

2888
01:57:22,236 --> 01:57:24,838
YEAR.  ANOTHER FLAGSHIP PROGRAM 

2889
01:57:24,838 --> 01:57:30,477
THAT WE SUPPORT IS THE R 25 

2890
01:57:30,477 --> 01:57:32,680
SCIENCE OR YES PROGRAM.  THAT 

2891
01:57:32,680 --> 01:57:35,215
WAS TALKED ABOUT IN A VISIT TO 

2892
01:57:35,215 --> 01:57:36,717
CHICAGO.  THIS PROGRAM 

2893
01:57:36,717 --> 01:57:40,554
INITIATED -- STARTED IN 2017, 

2894
01:57:40,554 --> 01:57:42,589
ENGAGES IN MIDDLE SCHOOL, HIGH 

2895
01:57:42,589 --> 01:57:43,757
SCHOOL AND UNDERGRADUATE 

2896
01:57:43,757 --> 01:57:47,695
STUDENTS AND THEIR TEACHERS.  

2897
01:57:47,695 --> 01:57:50,664
WITH RESEARCH EXPERIENCES.  OUTD

2898
01:57:50,664 --> 01:57:52,800
REACH ACTIVITIES AND CURRICULUM 

2899
01:57:52,800 --> 01:57:55,602
DEVELOPMENT.  SINCE ITS 

2900
01:57:55,602 --> 01:57:59,673
INCEPTION AROUND 2500 HAVE 

2901
01:57:59,673 --> 01:58:02,676
PARTICIPATED IN THESE ACTIVITIES

2902
01:58:02,676 --> 01:58:04,478
CURRENTLY WE HAVE 24 ACTIVE OR 

2903
01:58:04,478 --> 01:58:06,080
25 ACROSS THE COUNTRY.  CHICAGO 

2904
01:58:06,080 --> 01:58:08,349
IS ONE OF THEM.  

2905
01:58:08,349 --> 01:58:11,185
AND TWO OF THEM ARE SUPPORTED BY

2906
01:58:11,185 --> 01:58:16,757
OTHER ICS THAN NCI FOR FUNDING. 

2907
01:58:16,757 --> 01:58:20,561
THIS SLIDE PROVIDES A GLIMPSE 

2908
01:58:20,561 --> 01:58:22,763
INTO DEMOGRAPHICS AND THE CURE 

2909
01:58:22,763 --> 01:58:24,431
PORTFOLIO.  AS YOU CAN SEE ON 

2910
01:58:24,431 --> 01:58:25,799
THE PIE CHART, AROUND THE PIE 

2911
01:58:25,799 --> 01:58:30,404
CHARTS ON THE TOP, THE MAJORITY 

2912
01:58:30,404 --> 01:58:33,841
OF THIS ARE AFRICAN AMERICANS, 

2913
01:58:33,841 --> 01:58:35,709
34% AND LATINOS.  BUT SOME OF 

2914
01:58:35,709 --> 01:58:39,013
OUR PROGRAMS SUCH AS R 25 HAVE A

2915
01:58:39,013 --> 01:58:40,614
SIGNIFICANT REPRESENTATION FROM 

2916
01:58:40,614 --> 01:58:42,916
OTHER GROUPS INCLUDING AMERICAN 

2917
01:58:42,916 --> 01:58:46,420
INDIAN AND ALASKAN NATIVE.  14% 

2918
01:58:46,420 --> 01:58:53,127
FOR THE  25 YEARS AND THEN WE 

2919
01:58:53,127 --> 01:58:56,830
HAVE THE RURAL AREAS.  IN TERMS 

2920
01:58:56,830 --> 01:59:00,768
OF RESEARCH A LARGE PORTION IS 

2921
01:59:00,768 --> 01:59:02,803
BASIC CANCER, FOLLOWED BY SOCIAL

2922
01:59:02,803 --> 01:59:06,273
AND BEHAVIORAL SCIENCE AT 18%.  

2923
01:59:06,273 --> 01:59:08,809
AND TRANSLATIONAL AND CLINICAL 

2924
01:59:08,809 --> 01:59:12,913
AT 17 AND 6% RESPECTIVELY.  LESS

2925
01:59:12,913 --> 01:59:18,685
THAN 20% OF THE CURE PORTFOLIO 

2926
01:59:18,685 --> 01:59:21,321
IS FOCUSED ON CANCER HEALTH 

2927
01:59:21,321 --> 01:59:24,158
DISPARITIES AND AS TRENDS SHOWS 

2928
01:59:24,158 --> 01:59:26,360
CURE CONTINUE TO ATTRACT A 

2929
01:59:26,360 --> 01:59:28,062
DIVERSE POOL OF COMPETITIVE 

2930
01:59:28,062 --> 01:59:29,997
RESEARCHERS AND PHYSICIAN 

2931
01:59:29,997 --> 01:59:32,232
SCIENTISTS.  THIS COMPARES THE 

2932
01:59:32,232 --> 01:59:33,367
APPLICATION RECEIVED AND ALL 

2933
01:59:33,367 --> 01:59:37,004
THAT WE HAVE MADE IN 2023 AND 

2934
01:59:37,004 --> 01:59:39,173
2024.  THE LAST TWO YEARS.  AS 

2935
01:59:39,173 --> 01:59:43,210
YOU CAN SEE, ALL OF THE PROGRAMS

2936
01:59:43,210 --> 01:59:48,015
EXCEPT R 25, R 21 HAVE INCREASED

2937
01:59:48,015 --> 01:59:50,017
IN APPLICATION BUT WE HAVE NOT 

2938
01:59:50,017 --> 01:59:51,685
BEEN ABLE TO SUPPORT THE 

2939
01:59:51,685 --> 01:59:52,786
APPLICATION.  USUALLY THE BUDGET

2940
01:59:52,786 --> 01:59:55,355
SCENARIOS.  AND WITH THAT, I 

2941
01:59:55,355 --> 01:59:56,890
WILL HAND IT OVER TO THE 

2942
01:59:56,890 --> 02:00:06,166
CO-COUNSEL LOR, THANK YOU.

2943
02:00:06,166 --> 02:00:07,234
>> GOOD MORNING, I WILL
WRAP IT 

2944
02:00:07,234 --> 02:00:13,574
UP WITH TWO SLIDES.  IN 2018 THE

2945
02:00:13,574 --> 02:00:16,243
INTERMURAL WAS LAUNCHED THIS 

2946
02:00:16,243 --> 02:00:17,644
PROGRAM SUPPORTS INDIVIDUALS TO 

2947
02:00:17,644 --> 02:00:19,313
COME FROM DIFFERENT BACKGROUNDS 

2948
02:00:19,313 --> 02:00:22,049
TO COME TO THE NCI AND WORK WITH

2949
02:00:22,049 --> 02:00:23,383
INVESTIGATORS WITHIN THE NCI.  

2950
02:00:23,383 --> 02:00:25,052
NOT ONLY DO WE FOCUS ON MATCHING

2951
02:00:25,052 --> 02:00:26,887
THEM TO THE APPROPRIATE RESEARCH

2952
02:00:26,887 --> 02:00:29,423
MENTORS WITHIN THE NCI RESEARCH 

2953
02:00:29,423 --> 02:00:30,390
ENTERPRISE BUT ALSO SUPPORTING 

2954
02:00:30,390 --> 02:00:31,525
THEM IN THEIR CAREER DEVELOPMENT

2955
02:00:31,525 --> 02:00:33,227
BY MATCHING THEM WITH MENTORS 

2956
02:00:33,227 --> 02:00:34,461
OUTSIDE THEIR RESEARCH GROUPS 

2957
02:00:34,461 --> 02:00:37,397
AND PEER MENTOR TO SUPPORT THEM 

2958
02:00:37,397 --> 02:00:38,899
AS WELL.  OVER THIS -- OVER 

2959
02:00:38,899 --> 02:00:40,901
SEVEN COHORTS WE HAVE SUPPORTED 

2960
02:00:40,901 --> 02:00:43,003
106 SCHOLARS, NOTABLY TEN OF 

2961
02:00:43,003 --> 02:00:44,905
THEM ARE ONBOARDING THIS WEEK AS

2962
02:00:44,905 --> 02:00:50,911
WE SPEAK AND THIS INCLUDES 

2963
02:00:50,911 --> 02:00:52,446
POSTDOCS.  WE HAVE SUCCESSFULLY 

2964
02:00:52,446 --> 02:00:54,181
AND PROUDLY INCREASED THE NUMBER

2965
02:00:54,181 --> 02:00:57,217
OF AFRICAN AMERICAN AND HISPANIC

2966
02:00:57,217 --> 02:00:59,386
AS WELL AS NATIVE HAWAIIAN 

2967
02:00:59,386 --> 02:01:02,222
FELLOWS WITHIN THE NCI PROGRAM 

2968
02:01:02,222 --> 02:01:03,524
BASED OFF OF AN ANALYSIS 

2969
02:01:03,524 --> 02:01:04,625
SPANNING FIVE YEARS SO WE'RE 

2970
02:01:04,625 --> 02:01:05,792
VERY PROUD OF THIS PROGRAM AND 

2971
02:01:05,792 --> 02:01:12,833
THE SCHOLARS THAT WE SUPPORT.  

2972
02:01:12,833 --> 02:01:15,202
NOW THIS MIGHT SEEM LIKE A STRAY

2973
02:01:15,202 --> 02:01:18,105
BUT THE FACULTY RECRUITMENT WERE

2974
02:01:18,105 --> 02:01:23,143
THE FIRST PROGRAM WAS AN NIH 

2975
02:01:23,143 --> 02:01:24,578
PROGRAM.  IT PARALLEL TO THE 

2976
02:01:24,578 --> 02:01:26,146
CURE PROGRAM IT IS A HOLISTIC 

2977
02:01:26,146 --> 02:01:28,615
PROGRAM.  THAT THE NCI IS 

2978
02:01:28,615 --> 02:01:30,217
RESPONSIBLE FOR MANAGING, 

2979
02:01:30,217 --> 02:01:31,385
PARTICULARLY THE FACULTY COHORT 

2980
02:01:31,385 --> 02:01:33,820
PROGRAM ASPECT OF THIS.  WHICH 

2981
02:01:33,820 --> 02:01:35,489
THE THREE GOALS OF THOSE 

2982
02:01:35,489 --> 02:01:36,924
PROGRAMS ARE TO ADDRESS CULTURE 

2983
02:01:36,924 --> 02:01:38,792
WITHIN THE INSTITUTIONS THAT 

2984
02:01:38,792 --> 02:01:40,894
WERE FUNDED AND RECRUIT DIVERSE 

2985
02:01:40,894 --> 02:01:42,963
COHORTS OF FUK AND PROVIDE 

2986
02:01:42,963 --> 02:01:43,864
FACULTY WITH AN ENVIRONMENT OF 

2987
02:01:43,864 --> 02:01:45,432
SUPPORT THAT ACCELERATES THEIR 

2988
02:01:45,432 --> 02:01:47,534
CAREER WE'RE TALKING ABOUT ESIS 

2989
02:01:47,534 --> 02:01:50,304
IN WHICH THE INSTITUTIONS ARE 

2990
02:01:50,304 --> 02:01:52,739
PROVIDING THEM WITH MENTORSHIP, 

2991
02:01:52,739 --> 02:01:55,275
LOOKING AT POLICY TO CHANGE THE 

2992
02:01:55,275 --> 02:01:56,710
OVERALL CULTURE AND CATALYZE 

2993
02:01:56,710 --> 02:01:59,413
CHANGE IN THE LONG TERM FOR 

2994
02:01:59,413 --> 02:02:00,581
SUPPORTING THE FACULTY NOT ONLY 

2995
02:02:00,581 --> 02:02:02,316
THOSE RECRUITED IN THE PROGRAMS 

2996
02:02:02,316 --> 02:02:04,985
BUT GOING FORWARD.  OF THE 181 

2997
02:02:04,985 --> 02:02:06,420
FACULTY THEY'RE EXPECTED TO BE 

2998
02:02:06,420 --> 02:02:07,688
ONBOARDED THROUGH THESE PROGRAMS

2999
02:02:07,688 --> 02:02:09,990
25 OF THEM, A MINIMUM OF 25 WILL

3000
02:02:09,990 --> 02:02:12,226
BE CANCER AND TO DATE, 15 

3001
02:02:12,226 --> 02:02:13,427
FACULTY HAVE BEEN RECRUITED THAT

3002
02:02:13,427 --> 02:02:14,995
HAVE A CANCER FOCUS IN THEIR 

3003
02:02:14,995 --> 02:02:17,231
RESEARCH AND WE HOPE TO 

3004
02:02:17,231 --> 02:02:19,066
COLLABORATE WITH THEM AND WORK 

3005
02:02:19,066 --> 02:02:20,601
WITH THEM TO CONNECT THEM SO 

3006
02:02:20,601 --> 02:02:22,035
THAT WE SEE THEM IN OUR LONG 

3007
02:02:22,035 --> 02:02:24,905
POOL IN THE FUTURE.  AND SO WITH

3008
02:02:24,905 --> 02:02:26,940
THAT, I WILL SAY THANK YOU ON 

3009
02:02:26,940 --> 02:02:28,909
BEHALF OF MYSELF AND THE FELLOW 

3010
02:02:28,909 --> 02:02:37,618
SPEAKERS TODAY.  WE APPRECIATE 

3011
02:02:37,618 --> 02:02:38,452
YOUR THIE

3012
02:02:38,452 --> 02:02:39,119
TIME AND WE APPRECIATE WE GAVE 

3013
02:02:39,119 --> 02:02:42,222
YOU A LOT OF CONTENT: THANK YOU.

3014
02:02:42,222 --> 02:02:42,856
>> THIS IS GREAT.  THANK
YOU, 

3015
02:02:42,856 --> 02:02:44,891
ALL, FOR THAT WONDERFUL 

3016
02:02:44,891 --> 02:02:53,533
PRESENTATION.  WE HAVE AMPLE 

3017
02:02:53,533 --> 02:02:54,534
TIME FOR DISCUSSION.

3018
02:02:54,534 --> 02:02:56,203
>> THANK YOU SO MUCH FOR
THOSE 

3019
02:02:56,203 --> 02:02:57,537
PRESENTATIONS.  IT'S REALLY 

3020
02:02:57,537 --> 02:03:00,707
WONDERFUL TO HEAR ABOUT ALL OF 

3021
02:03:00,707 --> 02:03:05,412
THE SUPPORT THAT'S GOING ONTO 

3022
02:03:05,412 --> 02:03:09,349
BRING IN THE NEXT GENERATION OF 

3023
02:03:09,349 --> 02:03:11,251
RESEARCHERS.  I LOVE THE 

3024
02:03:11,251 --> 02:03:12,085
PROGRAMS.  SOMETIMES I WORRY 

3025
02:03:12,085 --> 02:03:14,321
WHEN YOU SEPARATE A POOL OF 

3026
02:03:14,321 --> 02:03:16,790
APPLICANTS IT ABSOLVES THE 

3027
02:03:16,790 --> 02:03:18,625
GREATER GOOD OR THE LARGER 

3028
02:03:18,625 --> 02:03:20,093
PROGRAMS FROM REALLY DISCUSSING 

3029
02:03:20,093 --> 02:03:22,496
AND TALKING ABOUT WHAT IS BEING 

3030
02:03:22,496 --> 02:03:25,966
DONE TO DIVERSIFY SO DR. BOWING 

3031
02:03:25,966 --> 02:03:26,733
HER I DON'T RECALL YOU 

3032
02:03:26,733 --> 02:03:28,302
MENTIONING AT ALL THE DIVERSITY 

3033
02:03:28,302 --> 02:03:34,408
OF THE RECIPIENTS.  AND ALSO 

3034
02:03:34,408 --> 02:03:36,910
IT'D BE GREAT TO HEAR ABOUT THE 

3035
02:03:36,910 --> 02:03:39,746
DIVERSITY OF THE APPLICANTS.  IT

3036
02:03:39,746 --> 02:03:41,348
WOULD BE GREAT TO TALK ABOUT THE

3037
02:03:41,348 --> 02:03:45,452
DIVERSITY OF INSTITUTIONS.  IF 

3038
02:03:45,452 --> 02:03:47,187
YOU CAN PLEASE SPEAK TO THAT 

3039
02:03:47,187 --> 02:03:48,388
THAT WOULD BE GREAT.

3040
02:03:48,388 --> 02:03:49,923
>> IT'S A CONCERN AND WE
DO 

3041
02:03:49,923 --> 02:03:50,991
SEPARATE THESE TWO THINGS BUT WE

3042
02:03:50,991 --> 02:03:52,592
ARE WORKING ON TRYING TO BRING 

3043
02:03:52,592 --> 02:03:54,728
MORE OF THESE IDEAS INTO MY 

3044
02:03:54,728 --> 02:03:57,731
PORTFOLIO AS COMPARED TO 

3045
02:03:57,731 --> 02:03:58,865
MARISSA'S PORTFOLIO.  THE -- SO 

3046
02:03:58,865 --> 02:04:00,767
WE DON'T HAVE A LOT OF DATA.  

3047
02:04:00,767 --> 02:04:02,469
THESE DATA ARE NOT AS EASY TO 

3048
02:04:02,469 --> 02:04:04,137
GET AS YOU MIGHT IMAGINE.  WE 

3049
02:04:04,137 --> 02:04:06,573
DID PUBLISH THE K99 DATA AND THE

3050
02:04:06,573 --> 02:04:08,675
NUMBERS ARE NOT ENCOURAGING THE 

3051
02:04:08,675 --> 02:04:10,410
REPRESENTATION OF MY NOORTS IS 

3052
02:04:10,410 --> 02:04:11,144
NOT WHERE IT SHOULD BE.  AND SO 

3053
02:04:11,144 --> 02:04:12,579
ONE OF THE DISCUSSIONS THAT'S 

3054
02:04:12,579 --> 02:04:14,281
HAPPENING AT THE MOMENT IS HOW 

3055
02:04:14,281 --> 02:04:17,451
DO WE ADDRESS IT WITHIN THE NCI,

3056
02:04:17,451 --> 02:04:18,752
RIGHT?  AND WE CAN TALK ABOUT 

3057
02:04:18,752 --> 02:04:20,387
MORE OF WHAT THOSE MIGHT LOOK 

3058
02:04:20,387 --> 02:04:21,988
LIKE.  INSTITUTIONAL DIVERSITY 

3059
02:04:21,988 --> 02:04:23,657
IS ALSO A CHALLENGE.  WHEN YOU 

3060
02:04:23,657 --> 02:04:28,895
LOOK AT THE DATA WE KNOW THAT 

3061
02:04:28,895 --> 02:04:31,965
THE BIGGEST INSTITUTION CONSUME 

3062
02:04:31,965 --> 02:04:34,434
THE MOST RESOURCES.  WE HAVE A 

3063
02:04:34,434 --> 02:04:35,402
HANDFUL OF INSTITUTIONS THAT 

3064
02:04:35,402 --> 02:04:38,705
HAVE SIX OR MORE T32S FROM THE 

3065
02:04:38,705 --> 02:04:39,973
NCI.  THAT IS A CONCERN.  I 

3066
02:04:39,973 --> 02:04:43,176
THINK THAT'S A LOT.  AND I THINK

3067
02:04:43,176 --> 02:04:44,010
THERE ARE OPPORTUNITIES FOR 

3068
02:04:44,010 --> 02:04:46,213
BROADENING THAT OUT.  WE HAVE 

3069
02:04:46,213 --> 02:04:47,781
ONE MECHANISM WHICH IS 

3070
02:04:47,781 --> 02:04:49,983
INSTRUCTIVE IN THIS COON TEXT 

3071
02:04:49,983 --> 02:04:52,452
WHICH IS OUR F99 MECHANISM 

3072
02:04:52,452 --> 02:04:53,687
THAT'S OUR GRAD STUDENT AWARD 

3073
02:04:53,687 --> 02:04:56,356
AND THAT AWARD REQUIRES AN 

3074
02:04:56,356 --> 02:04:59,626
INSTITUTIONAL NOOM NATION 

3075
02:04:59,626 --> 02:05:03,764
MEANING THAT ANY INSTITUTION CAN

3076
02:05:03,764 --> 02:05:05,265
ONLY SUBMIT ONE CANDIDATE AND 

3077
02:05:05,265 --> 02:05:07,000
WITH THAT ONE -- WITH THAT AWARD

3078
02:05:07,000 --> 02:05:10,070
WE SEE A MUCH BROADER 

3079
02:05:10,070 --> 02:05:10,771
INSTITUTION NALG PARTICIPATION 

3080
02:05:10,771 --> 02:05:12,973
THAN WE SEE FLEX WITH THE K99 

3081
02:05:12,973 --> 02:05:14,908
AWARD WHICH IS MUCH MORE 

3082
02:05:14,908 --> 02:05:18,011
TRADITIONAL OPEN COMPOSITION.  

3083
02:05:18,011 --> 02:05:22,215
SO THAT IS STRICT -- INSTRUCTIVE

3084
02:05:22,215 --> 02:05:23,517
TO US.  

3085
02:05:23,517 --> 02:05:24,484
WHETHER WE WANT TO THINK ABOUT 

3086
02:05:24,484 --> 02:05:26,753
CAPPING THE NUMBER OF GIVEN TYPE

3087
02:05:26,753 --> 02:05:29,122
OF AWARDS TO CERTAIN 

3088
02:05:29,122 --> 02:05:30,323
INSTITUTIONS AND SO ON.  

3089
02:05:30,323 --> 02:05:30,991
CERTAINLY SOMETHING THAT IS ON 

3090
02:05:30,991 --> 02:05:31,958
OUR MINDS.

3091
02:05:31,958 --> 02:05:33,160
>> YEAH.  THANK YOU SO
MUCH FOR 

3092
02:05:33,160 --> 02:05:35,262
THAT RESPONSE AND I DO THINK 

3093
02:05:35,262 --> 02:05:37,264
THERE PROBABLY ARE QUITE A FEW 

3094
02:05:37,264 --> 02:05:39,065
LESSONS THAT CAN BE LEARNED FROM

3095
02:05:39,065 --> 02:05:40,367
THE WORK THAT THE TEAM IS DOING 

3096
02:05:40,367 --> 02:05:42,235
AROUND SUPPORT.  I THINK THAT'S 

3097
02:05:42,235 --> 02:05:44,137
GREAT.  BUT I THINK ALSO THAT --

3098
02:05:44,137 --> 02:05:46,072
THAT'S AN INTERESTING IDEA TO 

3099
02:05:46,072 --> 02:05:48,909
THINK ABOUT CAPPING THE NUMBER 

3100
02:05:48,909 --> 02:05:51,812
OF AWARDS AT THESE LARGER 

3101
02:05:51,812 --> 02:05:53,046
INSTITUTIONS BECAUSE WE HAD A 

3102
02:05:53,046 --> 02:05:53,847
CONVERSATION TALKING ABOUT THE 

3103
02:05:53,847 --> 02:05:58,151
FACT THAT THE INDIRECTS ARE OUT 

3104
02:05:58,151 --> 02:06:02,823
OF OUR CONTROL, RIGHT?

3105
02:06:02,823 --> 02:06:04,024
WHICH REDUCES THE AMOUNT OF 

3106
02:06:04,024 --> 02:06:04,724
FUNDS THAT WE CAN DELIVER.  YOU 

3107
02:06:04,724 --> 02:06:06,293
LOOK AT THE NUMBER OF AWARDS 

3108
02:06:06,293 --> 02:06:08,328
THAT ARE GIVEN TO THOSE 

3109
02:06:08,328 --> 02:06:10,063
INSTITUTIONS THAT HAVE VERY HIGH

3110
02:06:10,063 --> 02:06:11,364
ENDOWMENTS.  THEY HAVE THE 

3111
02:06:11,364 --> 02:06:12,666
INFRASTRUCTURE.  THEY HAVE THE 

3112
02:06:12,666 --> 02:06:13,633
HOUSE.  THEY HAVE THE STOVE 

3113
02:06:13,633 --> 02:06:15,836
ALREADY.  IS THERE ANY WAY THAT 

3114
02:06:15,836 --> 02:06:18,605
WE POTENTIALLY CAN START TO 

3115
02:06:18,605 --> 02:06:19,840
DISSEMINATE BROADLY, MORE 

3116
02:06:19,840 --> 02:06:21,608
BROADLY SO WE CAN START TO BUILD

3117
02:06:21,608 --> 02:06:23,210
AN INFRASTRUCTURE TO OTHER 

3118
02:06:23,210 --> 02:06:24,244
INSTITUTIONS.

3119
02:06:24,244 --> 02:06:27,747
>> THE T32 IS ALSO -- HAS
ITS --

3120
02:06:27,747 --> 02:06:30,250
AN ASPECT TO IT THAT IS NOT THE 

3121
02:06:30,250 --> 02:06:31,718
INTENTION WHICH IS PEOPLE FEEL 

3122
02:06:31,718 --> 02:06:35,222
PARTICULARLY AS THEY TRY TO WORK

3123
02:06:35,222 --> 02:06:36,656
TOWARDS A CANCER CENTER IS 

3124
02:06:36,656 --> 02:06:37,624
THAT'S NOT SOMETHING THAT'S 

3125
02:06:37,624 --> 02:06:39,059
FORMALLY SAID.  THAT'S SOMETHING

3126
02:06:39,059 --> 02:06:43,230
THE COMMUNITY REFLECTS SO YOU 

3127
02:06:43,230 --> 02:06:44,698
COULD ARGUE IF YOU'VE BEEN IN A 

3128
02:06:44,698 --> 02:06:48,134
CANCER CENTER FOR X NUMBER OF 

3129
02:06:48,134 --> 02:06:49,870
DECADES MAYBE YOU DON'T NEED 

3130
02:06:49,870 --> 02:06:51,438
THOSE AS MANY ANYMORE.  I HEAR 

3131
02:06:51,438 --> 02:06:56,343
YOU ON THAT.

3132
02:06:56,343 --> 02:06:58,778
>> THANKS.  DR. HAYES.

3133
02:06:58,778 --> 02:07:01,648
>> I HAVE A QUESTION ABOUT
THE 

3134
02:07:01,648 --> 02:07:03,583
K99 AWARDS.  YOU SHOWED SOME 

3135
02:07:03,583 --> 02:07:06,653
DATA ABOUT TRANSITIONING TO R 

3136
02:07:06,653 --> 02:07:08,889
AWARDS FROM THE K99 AND SOME OF 

3137
02:07:08,889 --> 02:07:11,191
THE APPLICANTS THAT, YOU KNOW, 

3138
02:07:11,191 --> 02:07:12,926
IS A REDUCTION FROM THE NUMBER 

3139
02:07:12,926 --> 02:07:16,596
WHO RECEIVED THE K99.  DO WE 

3140
02:07:16,596 --> 02:07:19,165
HAVE ANY DATA ON WHAT HAPPENS TO

3141
02:07:19,165 --> 02:07:23,603
THEM OTHERWISE?  WHAT I MANE IS,

3142
02:07:23,603 --> 02:07:25,972
 -- MEAN IS, THOSE FOLKS ARE 

3143
02:07:25,972 --> 02:07:26,673
RECRUITABLE.  

3144
02:07:26,673 --> 02:07:29,543
THAT'S THE ONES YOU WANT IN YOUR

3145
02:07:29,543 --> 02:07:31,244
INSTITUTIONS THAT HAVE -- BEEN 

3146
02:07:31,244 --> 02:07:33,647
GIVEN THE K99.  AND NOT TO SAY 

3147
02:07:33,647 --> 02:07:35,181
ANYTHING POSITIVE OR NEGATIVE 

3148
02:07:35,181 --> 02:07:36,917
BUT SOME OF THOSE PERSONS ARE 

3149
02:07:36,917 --> 02:07:40,921
GOING INTO INDUSTRY AND ARE NOT 

3150
02:07:40,921 --> 02:07:42,589
TRANSITIONING TO R AWARDS 

3151
02:07:42,589 --> 02:07:44,724
BECAUSE THEY'VE TAKE AN JOB THAT

3152
02:07:44,724 --> 02:07:45,425
DOESN'T REQUIRE GRANT SUPPORT.  

3153
02:07:45,425 --> 02:07:48,895
IS THERE A WAY TO SEE HOW MANY 

3154
02:07:48,895 --> 02:07:50,864
OVER TIME ARE TRANSITIONING TO 

3155
02:07:50,864 --> 02:07:53,033
NON GRANT SUPPORTED POSITIONS AS

3156
02:07:53,033 --> 02:07:54,768
OPPOSED TO GRANT SUPPORTED 

3157
02:07:54,768 --> 02:07:55,101
POSITIONS?

3158
02:07:55,101 --> 02:07:56,570
>> SO IN THE INITIAL
TRANSITION 

3159
02:07:56,570 --> 02:07:59,906
IS VERY EASY TO ANSWER THAT 

3160
02:07:59,906 --> 02:08:02,042
BECAUSE WE OBSERVE IT AND THEY 

3161
02:08:02,042 --> 02:08:03,810
DO TRANSITION TO ACADEMIC 

3162
02:08:03,810 --> 02:08:04,911
POSITIONS AND THE PORTFOLIO 

3163
02:08:04,911 --> 02:08:12,719
WHICH IS MANAGED BY OUR SISTER 

3164
02:08:12,719 --> 02:08:14,654
GROUPS.  IT'S PROBABLY LESS THAN

3165
02:08:14,654 --> 02:08:16,590
5%.  WHEN WE LOOK FURTHER DOWN 

3166
02:08:16,590 --> 02:08:17,691
THE LINE WE CAN ACTUALLY OBSERVE

3167
02:08:17,691 --> 02:08:19,526
A SUSTAINED FUNDING IN OUR 

3168
02:08:19,526 --> 02:08:20,727
COHORT AND SOME OF THESE DATA 

3169
02:08:20,727 --> 02:08:22,762
ARE IN THE PAPER BUT OF COURSE 

3170
02:08:22,762 --> 02:08:24,864
THERE IS SOME ATTRITION AS IN 

3171
02:08:24,864 --> 02:08:26,433
ANY OF THE, I DON'T WANT TO USE 

3172
02:08:26,433 --> 02:08:28,868
THE PIPELINE WORD BUT IN ANY OF 

3173
02:08:28,868 --> 02:08:31,204
OUR PATHWAYS.  I THINK FOR THIS 

3174
02:08:31,204 --> 02:08:32,806
PARTICULAR PATHWAY, THAT 

3175
02:08:32,806 --> 02:08:34,407
ATTRITION LEVEL IS SIGNIFICANTLY

3176
02:08:34,407 --> 02:08:37,177
LOWER THAN, FOR EXAMPLE, OUR F32

3177
02:08:37,177 --> 02:08:38,645
PATHWAY OR OTHER PATHWAYS.

3178
02:08:38,645 --> 02:08:40,780
>> OKAY, GOOD, THAT'S MY
NEXT 

3179
02:08:40,780 --> 02:08:41,047
QUESTION.

3180
02:08:41,047 --> 02:08:43,149
>> WE REALLY SEE THIS AS
THE 

3181
02:08:43,149 --> 02:08:46,019
COHORT AS OUR PI REPLACEMENT OF 

3182
02:08:46,019 --> 02:08:47,420
COHORT PATHWAY.

3183
02:08:47,420 --> 02:08:48,288
>> THANK YOU.

3184
02:08:48,288 --> 02:08:57,697
>> GREAT.  ANN, I SEE YOUR
HAND.

3185
02:08:57,697 --> 02:09:00,166
PLEASE UNMUTE.

3186
02:09:00,166 --> 02:09:01,468
>> THANK YOU, OLIVER, I
DON'T 

3187
02:09:01,468 --> 02:09:02,402
REMEMBER I DON'T RECALL OF BEING

3188
02:09:02,402 --> 02:09:04,437
IN THE POSITION THAT WE'VE BEEN 

3189
02:09:04,437 --> 02:09:06,840
IN AT THE MOMENT AND WE'RE 

3190
02:09:06,840 --> 02:09:08,775
ENTERING AN ERA WHERE WE NEED 

3191
02:09:08,775 --> 02:09:11,311
MORE AND MORE YOUNG 

3192
02:09:11,311 --> 02:09:12,078
INVESTIGATORS BECAUSE THEY ARE 

3193
02:09:12,078 --> 02:09:13,380
MORE IN TUNE WITH THE SCIENCE 

3194
02:09:13,380 --> 02:09:14,748
THAT WE HAVE TO DO GOING FORWARD

3195
02:09:14,748 --> 02:09:17,917
AND ESPECIALLY TODAY WE TALK A 

3196
02:09:17,917 --> 02:09:19,386
LOT ABOUT THIS WHOLE ISSUE OF 

3197
02:09:19,386 --> 02:09:21,588
WHAT IS AI GOING TO BRING TO 

3198
02:09:21,588 --> 02:09:23,189
CANCER?  UNFORTUNATELY WE DON'T 

3199
02:09:23,189 --> 02:09:25,258
HAVE THAT MANY TRAINED 

3200
02:09:25,258 --> 02:09:27,827
INDIVIDUALS ACTUALLY IN A 

3201
02:09:27,827 --> 02:09:29,829
WORKFORCE IN THIS SPACE.  IN 

3202
02:09:29,829 --> 02:09:32,165
CANCER AND WE'RE GOING TO HAVE 

3203
02:09:32,165 --> 02:09:32,932
TO DO SOMETHING ABOUT IT AND I 

3204
02:09:32,932 --> 02:09:35,669
DON'T KNOW HOW WE DO IT.  I 

3205
02:09:35,669 --> 02:09:36,970
DON'T KNOW IF MAYBE LAUREN'S GOT

3206
02:09:36,970 --> 02:09:43,243
SOME IDEAS IN THIS REGARD BUT 

3207
02:09:43,243 --> 02:09:47,347
WE'RE GOING TO HAVE TO HAVE 

3208
02:09:47,347 --> 02:09:48,014
INVESTIGATORS TRULY UNDERSTAND 

3209
02:09:48,014 --> 02:09:50,250
WITH VERY SOPHISTICATED 

3210
02:09:50,250 --> 02:09:51,117
MATHEMATICS.  I DON'T KNOW, WE 

3211
02:09:51,117 --> 02:09:53,286
HAVE LOTS OF THINGS TO THINK 

3212
02:09:53,286 --> 02:09:54,521
ABOUT HERE BUT I THINK WE'RE 

3213
02:09:54,521 --> 02:09:56,690
GOING TO NEED SOME REAL EMPHASIS

3214
02:09:56,690 --> 02:09:58,525
HERE ESPECIALLY IN THE NEXT FIVE

3215
02:09:58,525 --> 02:10:00,527
YEARS AND I WAS WONDERING ARE 

3216
02:10:00,527 --> 02:10:04,264
WE -- DO WE HAVE A WAY TO PAY 

3217
02:10:04,264 --> 02:10:07,434
ATTENTION TO THAT?

3218
02:10:07,434 --> 02:10:09,302
>> I'M NOT SURE WE HAVE A
GOOD 

3219
02:10:09,302 --> 02:10:11,104
WAY TO PAY ATTENTION TO THAT IN 

3220
02:10:11,104 --> 02:10:15,041
A HOLISTIC WAY.  IT IS ON OUR 

3221
02:10:15,041 --> 02:10:16,910
MINDS.  THE PODCAST IS ONE OF 

3222
02:10:16,910 --> 02:10:18,511
THEM.  WE HAD A RECENT EPISODE 

3223
02:10:18,511 --> 02:10:20,513
WITH AI AND CANCER RESEARCH.  

3224
02:10:20,513 --> 02:10:22,082
WE'RE TRYING TO GET YOUNG PEOPLE

3225
02:10:22,082 --> 02:10:24,918
WHO HAVE MATHEMATICAL BRAINS TO 

3226
02:10:24,918 --> 02:10:31,091
THINK OF THEMSELVES AS PEOPLE 

3227
02:10:31,091 --> 02:10:34,360
WHO ARE CANCER RESEARCHERS.  WE 

3228
02:10:34,360 --> 02:10:40,667
WANT TO BRING PEOPLE WITH THOSE 

3229
02:10:40,667 --> 02:10:43,103
DISCIPLINES INTO THOSE FIELDS 

3230
02:10:43,103 --> 02:10:43,937
AND THOSE MID-CAREER BRINGING 

3231
02:10:43,937 --> 02:10:44,904
THOSE PEOPLE INTO OUR FIELDS.  

3232
02:10:44,904 --> 02:10:47,640
THERE ARE SOME IDEAS.  IT'S NOT 

3233
02:10:47,640 --> 02:10:51,010
A GREAT TIME TO LAUNCH NEW 

3234
02:10:51,010 --> 02:10:51,978
PROGRAMS BUT CERTAINLY WE HAVE 

3235
02:10:51,978 --> 02:10:53,947
THIS ON OUR RADAR AS A REALLY 

3236
02:10:53,947 --> 02:10:58,451
IMPORTANT AREA OF INVESTMENT.  I

3237
02:10:58,451 --> 02:10:59,452
AGREE, CANCER RESEARCH NEEDS TO 

3238
02:10:59,452 --> 02:11:00,820
IMPROVE THE WAY IT COMPETES WITH

3239
02:11:00,820 --> 02:11:03,990
THAT TALENT.  WE NEED TO SEE 

3240
02:11:03,990 --> 02:11:07,761
OURSELVES MORE LIKE A SILICON 

3241
02:11:07,761 --> 02:11:16,269
VALLEY COME  -- COMPETING FOR 

3242
02:11:16,269 --> 02:11:16,770
THAT TALENT.

3243
02:11:16,770 --> 02:11:19,973
>> THE GOOGLE AND THE
MICROSOFTS

3244
02:11:19,973 --> 02:11:23,676
HAVE SIMILAR NEEDS WITH THEIR 

3245
02:11:23,676 --> 02:11:25,044
HEALTH CARE AND I THINK WE HAVE 

3246
02:11:25,044 --> 02:11:28,715
SUCH A STRONG PARTNER IN THIS 

3247
02:11:28,715 --> 02:11:28,948
REGARD.

3248
02:11:28,948 --> 02:11:30,817
>> YES.  AND WHAT WE ARE 

3249
02:11:30,817 --> 02:11:31,985
DEVELOPING WITH GOOGLE.  YES, 

3250
02:11:31,985 --> 02:11:33,686
YOU CAN WORK WITH GOOGLE AND 

3251
02:11:33,686 --> 02:11:35,622
WORK WITH NCI AT THE SAME TIME. 

3252
02:11:35,622 --> 02:11:36,923
THAT IS POSSIBLE.  OR WORK IN 

3253
02:11:36,923 --> 02:11:39,159
ANY OF THE GREAT INSTITUTIONS 

3254
02:11:39,159 --> 02:11:40,894
REPRESENTED BY OUR BOARD.  WE 

3255
02:11:40,894 --> 02:11:42,395
NEED TO GET THAT MESSAGE IN.

3256
02:11:42,395 --> 02:11:44,130
>> YES.  THANK YOU.

3257
02:11:44,130 --> 02:11:45,331
>> AS OLIVER MENTIONED AND
TO 

3258
02:11:45,331 --> 02:11:47,867
THE QUESTION, I THINK SOMETHING 

3259
02:11:47,867 --> 02:11:50,303
THAT WE HAVE TO NOT FORGET IS 

3260
02:11:50,303 --> 02:11:52,939
NCI CANNOT DO EVERYTHING.  WE 

3261
02:11:52,939 --> 02:11:55,308
NEED MORE HELP AND ASSIST FROM 

3262
02:11:55,308 --> 02:11:56,910
CANCER CENTERS.  THEY HAVE TO 

3263
02:11:56,910 --> 02:11:58,411
FOCUS MORE ON THESE PROGRAMS AND

3264
02:11:58,411 --> 02:12:00,480
ALSO FOCUS ON DIVERSIFYING THE 

3265
02:12:00,480 --> 02:12:04,717
CANCER FOCUS AND WE ALSO TO 

3266
02:12:04,717 --> 02:12:06,085
PARTNER WITH THE -- MAYBE THE 

3267
02:12:06,085 --> 02:12:07,854
PRIVATE SECTOR TO FOCUS ON THESE

3268
02:12:07,854 --> 02:12:08,855
AREAS.  WE CANNOT DO EVERYTHING 

3269
02:12:08,855 --> 02:12:10,323
BY OURSELVES.

3270
02:12:10,323 --> 02:12:12,091
>> YEAH, I THINK A
DIFFERENT WAY

3271
02:12:12,091 --> 02:12:13,927
OF THINKING ABOUT IT IN TERMS OF

3272
02:12:13,927 --> 02:12:16,896
SAYING NEW PROGRAMS, MAYBE IT'S 

3273
02:12:16,896 --> 02:12:22,068
REBALANCING, RIGHT, THE 

3274
02:12:22,068 --> 02:12:22,335
PORTFOLIO.

3275
02:12:22,335 --> 02:12:24,270
>> THANK YOU FOR THESE
WONDERFUL

3276
02:12:24,270 --> 02:12:26,439
PRESENTATIONS.  THIS IS AN AREA 

3277
02:12:26,439 --> 02:12:30,276
NEAR AND DEAR TO MY HEART.  THE 

3278
02:12:30,276 --> 02:12:31,144
CURRENT LANDSCAPE IS A LITTLE 

3279
02:12:31,144 --> 02:12:32,645
BIT FRIGHTENING FOR DIVERSITY.  

3280
02:12:32,645 --> 02:12:34,247
I WILL SAY THAT THE WORK THAT 

3281
02:12:34,247 --> 02:12:36,082
YOU'RE DOING IS VERY HEARTENING 

3282
02:12:36,082 --> 02:12:38,284
IN THAT WAY, SEE THAT THE NIH IS

3283
02:12:38,284 --> 02:12:42,222
INTERESTED IN THIS AREA.  AND I 

3284
02:12:42,222 --> 02:12:45,525
USED NIH'S INTEREST IN DIVERSITY

3285
02:12:45,525 --> 02:12:49,262
AS A FLAG I FLY IN A WAY THAT 

3286
02:12:49,262 --> 02:12:52,866
YOU CAN SAY THAT DIVERSITY HAS A

3287
02:12:52,866 --> 02:12:53,733
SPECIFIC SCIENTIFIC PURPOSE AND 

3288
02:12:53,733 --> 02:12:55,735
IS IMPORTANT TO OUR NATION AND 

3289
02:12:55,735 --> 02:12:57,303
SO IT IS SOMETHING THAT WE MUST 

3290
02:12:57,303 --> 02:12:58,805
PURSUE IN ORDER TO BE 

3291
02:12:58,805 --> 02:13:01,207
SUCCESSFUL.  AND SO, AGAIN, VERY

3292
02:13:01,207 --> 02:13:02,175
HEARTENED BY THE COMMITMENT 

3293
02:13:02,175 --> 02:13:04,210
THAT'S THERE.  THAT SAID, I 

3294
02:13:04,210 --> 02:13:05,345
GUESS I HAVE TO ISSUE THIS 

3295
02:13:05,345 --> 02:13:07,080
CHALLENGE IN THE SENSE THAT I'M 

3296
02:13:07,080 --> 02:13:08,915
AT INSTITUTIONS, WE ALL SEE 

3297
02:13:08,915 --> 02:13:10,750
INSTITUTIONS NATIONALLY 

3298
02:13:10,750 --> 02:13:11,417
INCLUDING OUR INDUSTRIAL 

3299
02:13:11,417 --> 02:13:12,886
PARTNERS WHEN WE TALK ABOUT THE 

3300
02:13:12,886 --> 02:13:14,821
GOOGLES AND THE MICROSOFTS, ET 

3301
02:13:14,821 --> 02:13:18,658
CETERA, WHO ARE MOVING AWAY VERY

3302
02:13:18,658 --> 02:13:23,363
QUICKLY AND VERY DISHEARTENING 

3303
02:13:23,363 --> 02:13:24,898
THAT DIVERSITY IS VALUABLE AND 

3304
02:13:24,898 --> 02:13:26,799
HAS A BUSINESS CASE AND IS 

3305
02:13:26,799 --> 02:13:28,368
SOMETHING WE SHOULD BE PURSUING 

3306
02:13:28,368 --> 02:13:29,669
NOT ONLY FOR THAT BUSINESS CASE 

3307
02:13:29,669 --> 02:13:32,138
BUT ALSO THAT EQUITY.  SO I 

3308
02:13:32,138 --> 02:13:35,141
GUESS MOVING TO THE QUESTION, 

3309
02:13:35,141 --> 02:13:36,542
KIND OF PIGGYBACKING ON WHAT 

3310
02:13:36,542 --> 02:13:37,810
DR. WING FIELD WAS, I THINK 

3311
02:13:37,810 --> 02:13:39,779
THERE'S REALLY IMPORTANT.  

3312
02:13:39,779 --> 02:13:43,683
THAT WE DO TRACK THESE DIVERSITY

3313
02:13:43,683 --> 02:13:44,284
STATIS

3314
02:13:44,284 --> 02:13:44,851
STATISTICS.  I THINK IT'S 

3315
02:13:44,851 --> 02:13:45,785
IMPORTANT THAT WE CONTINUE TO 

3316
02:13:45,785 --> 02:13:48,988
CARVE OUT WITH THE NIH'S AGAIN, 

3317
02:13:48,988 --> 02:13:50,757
VERY SCIENTIFICALLY SUPPORTED 

3318
02:13:50,757 --> 02:13:52,292
INTEREST AND DIVERSITY, MAKE 

3319
02:13:52,292 --> 02:13:57,230
SURE OUR K99S DO HAVE DIVERSITY 

3320
02:13:57,230 --> 02:13:58,765
STATISTICS AND SHOW WHAT THE 

3321
02:13:58,765 --> 02:14:00,400
SUCCESSES OF THOSE INDIVIDUALS 

3322
02:14:00,400 --> 02:14:03,069
ARE BECAUSE AS OUR COUNTRY 

3323
02:14:03,069 --> 02:14:09,342
CONTINUES TO DIVERSIFY IF WE DO 

3324
02:14:09,342 --> 02:14:12,946
NOT BRING EVERYBODY TO BRAER  

3325
02:14:12,946 --> 02:14:15,348
BEAR WE WILL MISS SOME OF THE 

3326
02:14:15,348 --> 02:14:17,183
BRILLIANT INDIVIDUALS THAT ARE 

3327
02:14:17,183 --> 02:14:18,551
GOING TO CREATE THE 

3328
02:14:18,551 --> 02:14:19,786
BREAKTHROUGHS OF TOMORROW.  

3329
02:14:19,786 --> 02:14:20,920
AGAIN, IT'S BEEN GREAT TO SEE 

3330
02:14:20,920 --> 02:14:23,823
THE COMMITMENT TO THAT AND THE 

3331
02:14:23,823 --> 02:14:24,424
PRESENTATIONS THAT HAVE BEEN 

3332
02:14:24,424 --> 02:14:26,292
THUS FAR.  JI THINK WE REALLY 

3333
02:14:26,292 --> 02:14:27,794
NEED TO DOUBLE DOWN. 

3334
02:14:27,794 --> 02:14:29,762
ONE QUICK SUGGESTION IF I MAY ON

3335
02:14:29,762 --> 02:14:31,731
THE CURE PROGRAM AND SOME OF 

3336
02:14:31,731 --> 02:14:32,899
THESE OTHERS WHERE WE HAVE A LOT

3337
02:14:32,899 --> 02:14:34,434
OF OTHER APPLICATIONS AND 

3338
02:14:34,434 --> 02:14:35,535
OBVIOUSLY WE CAN'T TAKE 

3339
02:14:35,535 --> 02:14:36,903
EVERYBODY.  WHEN I WEAR ONE OF 

3340
02:14:36,903 --> 02:14:40,239
MY HATS I'M A NEUROSURGEON, 

3341
02:14:40,239 --> 02:14:41,741
THERE IS THIS PROGRAM THEY HAVE 

3342
02:14:41,741 --> 02:14:45,411
WITH NIDS THAT HAS BEEN 

3343
02:14:45,411 --> 02:14:47,013
SUCCESSFUL IN TRAINING 

3344
02:14:47,013 --> 02:14:48,915
NEUROSCIENTISTS.  ONE OF THE 

3345
02:14:48,915 --> 02:14:50,083
BIGGEST SUCCESSES IS MOST OF 

3346
02:14:50,083 --> 02:14:52,018
THEM CANNOT BE AWARDED THE MONEY

3347
02:14:52,018 --> 02:14:54,721
BUT EVERYBODY THAT APPLIES GETS 

3348
02:14:54,721 --> 02:14:56,756
PUT IN PART OF THIS COHORT OF 

3349
02:14:56,756 --> 02:14:58,791
INDIVIDUALS WHO CONTINUES TO GET

3350
02:14:58,791 --> 02:15:01,394
TRAINING ON GRANT APPLICATIONS, 

3351
02:15:01,394 --> 02:15:02,295
MENTORING ON SPECIFIC AIMS AND 

3352
02:15:02,295 --> 02:15:03,496
THEY'VE BEEN ABLE TO SHOE THAT 

3353
02:15:03,496 --> 02:15:06,733
NOT ONLY AWARDEES HAVE BECOME 

3354
02:15:06,733 --> 02:15:07,834
SUCCESSFUL AS NEUROSURGEON 

3355
02:15:07,834 --> 02:15:09,369
SCIENTISTS BUT ALSO THE 

3356
02:15:09,369 --> 02:15:11,938
APPLICANTS.  I AM WONDERING IF 

3357
02:15:11,938 --> 02:15:12,939
WE CAN CONTINUE, TRACK THOSE 

3358
02:15:12,939 --> 02:15:14,941
PEOPLE THAT ARE APPLYING AND 

3359
02:15:14,941 --> 02:15:16,175
MAKE THOSE PART OF A VIRTUAL 

3360
02:15:16,175 --> 02:15:18,144
COHORT THAT WE CONTINUE TO 

3361
02:15:18,144 --> 02:15:18,378
MENTOR.

3362
02:15:18,378 --> 02:15:19,412
>> SURE AND WE SEE THE
SAME 

3363
02:15:19,412 --> 02:15:24,917
THING IN OUR K99 DATA TO THE 

3364
02:15:24,917 --> 02:15:31,324
POINT WHERE IT'S A JOKE.  WE 

3365
02:15:31,324 --> 02:15:32,692
HAVE THE EARLY SCIENTIST 

3366
02:15:32,692 --> 02:15:34,494
PROGRAM.  I DON'T KNOW IF YOUR 

3367
02:15:34,494 --> 02:15:36,896
AWARE OF THIS BUT IT INCLUDES 

3368
02:15:36,896 --> 02:15:38,231
SOME NEURO SERVICE AS WELL AND 

3369
02:15:38,231 --> 02:15:40,867
IT TAKES A LOT OF IDEAS AND 

3370
02:15:40,867 --> 02:15:43,236
TRIES TO BUILD A COHORT.  I 

3371
02:15:43,236 --> 02:15:45,972
WANTED TO RETURN TO YOUR EARLIER

3372
02:15:45,972 --> 02:15:48,875
POINT.  ONE THING WE HAVE 

3373
02:15:48,875 --> 02:15:50,343
OBSERVED AND NOTED THE ANECDOTAL

3374
02:15:50,343 --> 02:15:53,279
EXPERIENCE IS GRANTS LIKE K99 

3375
02:15:53,279 --> 02:15:54,447
FOR EXAMPLE, IT'S ALMOST THAT 

3376
02:15:54,447 --> 02:15:56,482
YOU ARE IN A LAB WHERE PEOPLE 

3377
02:15:56,482 --> 02:15:59,018
APPLIED AND GOT K99S BEFORE.  

3378
02:15:59,018 --> 02:16:02,321
YOU'RE GOING TO APPLY FOR A K 99

3379
02:16:02,321 --> 02:16:05,058
IF YOUR MENTOR IS WELL-VERSED IN

3380
02:16:05,058 --> 02:16:07,126
THAT.  THAT IS HARD TO 

3381
02:16:07,126 --> 02:16:07,794
TRANSPLANT.  THE REASON WE'RE 

3382
02:16:07,794 --> 02:16:09,328
NOT GETTING A MORE DIVERSE POOL 

3383
02:16:09,328 --> 02:16:11,931
OF APPLICANTS IS THAT THAT 

3384
02:16:11,931 --> 02:16:13,166
TRADITION IF YOU WILL, DOES NOT 

3385
02:16:13,166 --> 02:16:16,235
EXIST IN THOSE INSTITUTIONS AND 

3386
02:16:16,235 --> 02:16:19,005
WE'RE WORK WITHIN THE PROGRAM TO

3387
02:16:19,005 --> 02:16:20,506
TRY TO HELP TRANSPLANT SOME OF 

3388
02:16:20,506 --> 02:16:24,210
THOSE TRADITIONS BUT, YOU KNOW, 

3389
02:16:24,210 --> 02:16:26,045
PARTNERSHIPS BETWEEN ESTABLISHED

3390
02:16:26,045 --> 02:16:28,381
INSTITUTIONS LIKE YOUR OWN, 

3391
02:16:28,381 --> 02:16:29,015
INSTITUTIONS THAT DO NOT HAVE 

3392
02:16:29,015 --> 02:16:31,117
THAT HISTORY OF APPLYING FOR 

3393
02:16:31,117 --> 02:16:32,018
THESE MECHANISMS WOULD BE 

3394
02:16:32,018 --> 02:16:34,387
FABULOUS AND I WOULD LIKE TO SEE

3395
02:16:34,387 --> 02:16:36,355
THE CANCER CENTERS HELP THEIR 

3396
02:16:36,355 --> 02:16:38,291
COMMUNITY PEERS APPLY FOR K99S. 

3397
02:16:38,291 --> 02:16:40,460
THAT'S JUST ONE EXAMPLE.

3398
02:16:40,460 --> 02:16:43,663
>> I WAS JUST GOING TO SAY
ONE 

3399
02:16:43,663 --> 02:16:45,465
PIGGYBACK THING, I WAS GOING TO 

3400
02:16:45,465 --> 02:16:51,604
SAY THIS IS A PHENOMENAL EXAMPLE

3401
02:16:51,604 --> 02:16:54,040
THAT DOESN'T COST A TON OF MONEY

3402
02:16:54,040 --> 02:16:55,408
BUT I WOULD RAISE A HAND IS ONE 

3403
02:16:55,408 --> 02:16:58,444
OF THE PEOPLE IT BENEFITTED 

3404
02:16:58,444 --> 02:16:58,678
GREATLY.

3405
02:16:58,678 --> 02:17:00,313
>> THAT'S ACTUALLY WHAT I
WAS 

3406
02:17:00,313 --> 02:17:02,348
GOING TO SAY.  WE ARE FAMILIAR 

3407
02:17:02,348 --> 02:17:03,449
WITH THE EARLY ADVANCEMENT 

3408
02:17:03,449 --> 02:17:05,751
PROGRAM, THIS IS A PROGRAM THAT 

3409
02:17:05,751 --> 02:17:09,255
IS AN NCI-WIDE ACTIVITY.  

3410
02:17:09,255 --> 02:17:12,658
MANAGED BY OUR CENTER.  AND THE 

3411
02:17:12,658 --> 02:17:16,863
GOAL IS THAT THE APPLICANT 

3412
02:17:16,863 --> 02:17:19,432
SUBMIT AND PROVIDE MENTORSHIP 

3413
02:17:19,432 --> 02:17:21,400
AND HELP THEM TO SUBMIT A 

3414
02:17:21,400 --> 02:17:22,768
COMPETITIVE APPLICATION.  MAYBE 

3415
02:17:22,768 --> 02:17:24,070
WE CAN DEVELOP A SIMILAR 

3416
02:17:24,070 --> 02:17:27,540
PROGRAMS FOR FELLOWSHIP AND 

3417
02:17:27,540 --> 02:17:31,110
DEVELOPMENT AT NCI AND ALSO THE 

3418
02:17:31,110 --> 02:17:41,554
MODEL THAT DR.  RATHMELL 

3419
02:17:42,221 --> 02:17:43,022
MENTIONED.  MAYBE WE CAN PARTNER

3420
02:17:43,022 --> 02:17:46,159
WITH THE NCR AND THOSE THAT THAT

3421
02:17:46,159 --> 02:17:48,361
HAVE COMPETITIVE SCORES THAT WE 

3422
02:17:48,361 --> 02:17:50,463
CANNOT FUND THEM, THAT THEY ARE 

3423
02:17:50,463 --> 02:17:52,732
READY TO SUPPORT THEM.  THIS CAN

3424
02:17:52,732 --> 02:18:00,473
BE A MODEL THAT WE CAN DISCUSS

3425
02:18:00,473 --> 02:18:03,142
>> I JUST WANTED TO COME
BACK TO

3426
02:18:03,142 --> 02:18:04,911
THE INSTITUTIONS THAT MIGHT BE 

3427
02:18:04,911 --> 02:18:05,645
MORE PREPARED ALREADY VERSUS 

3428
02:18:05,645 --> 02:18:07,680
THOSE THAT MAY OR MAY NOT.  I 

3429
02:18:07,680 --> 02:18:10,183
THINK, YOU KNOW, A TON OF 

3430
02:18:10,183 --> 02:18:11,384
INVESTMENT HAS BEEN MADE, YOU 

3431
02:18:11,384 --> 02:18:13,953
KNOW, THE MINORITIES AND THE 

3432
02:18:13,953 --> 02:18:14,453
INSTITUTIONS TO BUILD 

3433
02:18:14,453 --> 02:18:15,555
INFRASTRUCTURE APPROPRIATELY.  

3434
02:18:15,555 --> 02:18:17,456
WE STILL HAVE PATHWAYS TO GO, I 

3435
02:18:17,456 --> 02:18:19,592
UNDERSTAND THAT.  BUT I THINK 

3436
02:18:19,592 --> 02:18:20,059
THERE COULD BE SOME 

3437
02:18:20,059 --> 02:18:21,694
OPPORTUNITIES TO RETHINK THE 

3438
02:18:21,694 --> 02:18:23,162
PORTFOLIO AND THE TYPES OF 

3439
02:18:23,162 --> 02:18:26,365
PROGRAMS.  I THINK, YOU KNOW, 

3440
02:18:26,365 --> 02:18:27,233
LAB-BASED RESEARCH TENDS TO BE 

3441
02:18:27,233 --> 02:18:29,835
MORE EXPENSIVE THAN DIGITAL 

3442
02:18:29,835 --> 02:18:31,137
RESEARCH.  RIGHT?  SO WHY CAN'T 

3443
02:18:31,137 --> 02:18:32,905
WE THINK ABOUT FOCUSING PROGRAMS

3444
02:18:32,905 --> 02:18:34,240
SPECIFICALLY IN THOSE AREAS?  

3445
02:18:34,240 --> 02:18:37,877
AND I DO AGREE, LEVERAGING THE 

3446
02:18:37,877 --> 02:18:38,611
INFRASTRUCTURE, PARTICULARLY THE

3447
02:18:38,611 --> 02:18:39,579
ADMINISTRATIVE COMPONENTS OF 

3448
02:18:39,579 --> 02:18:41,547
RUNNING THESE TYPES OF PROGRAMS,

3449
02:18:41,547 --> 02:18:44,483
AT THE CANCER CENTERS OR AT THE 

3450
02:18:44,483 --> 02:18:45,351
LARGER INSTITUTIONS.  WHERE I 

3451
02:18:45,351 --> 02:18:48,487
THINK WE MAY HAVE TO THINK 

3452
02:18:48,487 --> 02:18:54,260
OUTSIDE THE BOX BECAUSE I THINK 

3453
02:18:54,260 --> 02:18:55,995
WE'RE ALL READY BUT WE HAVE TO 

3454
02:18:55,995 --> 02:18:57,597
CONSIDER WHERE CAN WE GET THE 

3455
02:18:57,597 --> 02:19:00,032
GREATEST RETURN ON INVESTMENT?  

3456
02:19:00,032 --> 02:19:01,567
AND ALSO ARE WE THINKING ABOUT 

3457
02:19:01,567 --> 02:19:02,835
THE FUTURE OF SCIENCE?  RIGHT?  

3458
02:19:02,835 --> 02:19:05,104
AND I AGREE WITH ANN WE ARE IN 

3459
02:19:05,104 --> 02:19:07,340
THE AGE OF DATA AND SO I WOULD 

3460
02:19:07,340 --> 02:19:11,377
REALLY LOVE TO SEE MORE PROGRAMS

3461
02:19:11,377 --> 02:19:13,412
THAT ARE REALLY BRINGING, RIGHT,

3462
02:19:13,412 --> 02:19:15,848
EVERYONE, RIGHT, UP TO SPEED.  

3463
02:19:15,848 --> 02:19:17,783
AS TO WHERE WE ARE IN TERMS OF 

3464
02:19:17,783 --> 02:19:21,520
DATA ANALYSIS, INFORMATICS AND 

3465
02:19:21,520 --> 02:19:22,989
ADVANCED DIGITAL TECHNOLOGY SO 

3466
02:19:22,989 --> 02:19:26,659
JUST A FEW COMMENTS.  YEAH.

3467
02:19:26,659 --> 02:19:28,594
>> IT STRIKES ME THAT YOU
HAVE A

3468
02:19:28,594 --> 02:19:32,898
LOT OF DATA TO SAY WHAT WERE THE

3469
02:19:32,898 --> 02:19:34,734
PARTICULARS OF SUCCESS.  AND MY 

3470
02:19:34,734 --> 02:19:37,203
ASSUMPTION IS IS THAT A LOT OF 

3471
02:19:37,203 --> 02:19:40,906
THAT IS GOING TO BE BORN AT THE 

3472
02:19:40,906 --> 02:19:44,610
HIGH SCHOOL AND COLLEGE LEVEL.  

3473
02:19:44,610 --> 02:19:48,347
BECAUSE LEARNING, LET'S SAY, AI 

3474
02:19:48,347 --> 02:19:51,617
OR NOVEL TECHNIQUES, WHEN YOU'RE

3475
02:19:51,617 --> 02:19:54,020
IN MEDICAL TRAINING OR IN YOUR 

3476
02:19:54,020 --> 02:19:55,921
POSTDOC MAY BE TOO LATE AND YOU 

3477
02:19:55,921 --> 02:19:59,659
MAY NEED FUNDAMENTALS THAT WERE 

3478
02:19:59,659 --> 02:20:00,626
TAUGHT IN COLLEGE OR MAYBE AT 

3479
02:20:00,626 --> 02:20:03,229
THE HIGH SCHOOL LEVELS.  I 

3480
02:20:03,229 --> 02:20:06,098
REALLY ENCOURAGE TO LOOK AT THAT

3481
02:20:06,098 --> 02:20:08,734
DATA AND MAYBE BOLSTER TRAINING 

3482
02:20:08,734 --> 02:20:10,069
EARLIER AND FUNDING TRAIN 

3483
02:20:10,069 --> 02:20:11,570
EARLIER IN THE FUNDING PROCESS 

3484
02:20:11,570 --> 02:20:14,540
BECAUSE I THINK IT WILL BEAR 

3485
02:20:14,540 --> 02:20:16,242
FRUIT DOWN THE LINE.

3486
02:20:16,242 --> 02:20:17,410
>> THANK YOU FOR THAT
COMMENT.  

3487
02:20:17,410 --> 02:20:21,013
I DO WANT TO SAY I THINK A TREND

3488
02:20:21,013 --> 02:20:24,083
A COMMON ELEMENT WE SEE FOR 

3489
02:20:24,083 --> 02:20:26,752
SUCCESS FOR FELLOWS IS 

3490
02:20:26,752 --> 02:20:27,687
MENTORSHIP.  THAT COMES FROM YOU

3491
02:20:27,687 --> 02:20:29,855
AND OTHERS.  A MENTORSHIP AND 

3492
02:20:29,855 --> 02:20:30,790
ENCOURAGING THAT IS SOMETHING 

3493
02:20:30,790 --> 02:20:32,124
THAT, YOU KNOW, YOU SHOULD THINK

3494
02:20:32,124 --> 02:20:34,827
ABOUT, YOU SHOULD DO IS A THEME 

3495
02:20:34,827 --> 02:20:40,499
WE SEE WITHIN THE KCURE AND ALL 

3496
02:20:40,499 --> 02:20:42,001
THE PROGRAMS.  THAT'S A STRONG 

3497
02:20:42,001 --> 02:20:43,336
COMMON ELEMENT OF SUCCESS.

3498
02:20:43,336 --> 02:20:45,604
>> AND I WILL ALSO MENTION
AGAIN

3499
02:20:45,604 --> 02:20:48,441
THE R 25, YES.  IT STARTS FROM 

3500
02:20:48,441 --> 02:20:51,610
MIDDLE SCHOOL, HIGH SCHOOL AND 

3501
02:20:51,610 --> 02:20:55,414
THE TEACHERS.  WE HAVE A COUPLE 

3502
02:20:55,414 --> 02:21:03,189
OF R 25S THAT WERE FOCUSED ON 

3503
02:21:03,189 --> 02:21:04,890
THIS AND THIS IS WHY WE COULDN'T

3504
02:21:04,890 --> 02:21:06,759
SUPPORT THEM.  SO HOPEFULLY WE 

3505
02:21:06,759 --> 02:21:10,496
CAN MORE SUPPORT FROM THE R 25 

3506
02:21:10,496 --> 02:21:12,932
PROGRAM AND SO WE CAN SUPPORT 

3507
02:21:12,932 --> 02:21:14,834
MORE AND INVEST IN EARLY 

3508
02:21:14,834 --> 02:21:15,201
INTERVENTIONS.

3509
02:21:15,201 --> 02:21:17,470
>> GREAT.  WONDERFUL SET
OF 

3510
02:21:17,470 --> 02:21:20,906
PRESENTATIONS AND GREAT 

3511
02:21:20,906 --> 02:21:21,640
DISCUSSIONS, THANK YOU, ALL.

3512
02:21:21,640 --> 02:21:24,910
>> (APPLAUSE).

3513
02:21:24,910 --> 02:21:27,546
>> SO WE'VE EATEN ABOUT
TWO 

3514
02:21:27,546 --> 02:21:29,915
MINUTES INTO OUR COFFEE BREAK.  

3515
02:21:29,915 --> 02:21:32,718
I WOULD ASK EVERYONE TO BE BACK 

3516
02:21:32,718 --> 02:21:35,020
AROUND 11:33 IN YOUR SEATS IN SO

3517
02:21:35,020 --> 02:21:38,976
WE CAN START PROMPTLY AT 11:35. 

3518
02:21:38,976 --> 02:21:42,880
GREAT 

3519
02:21:42,880 --> 02:21:44,549
WE'RE GOING TO GO AHEAD TO THE 

3520
02:21:44,549 --> 02:21:46,017
NEXT PRESENTATION WHICH IS 

3521
02:21:46,017 --> 02:21:47,652
CHILDHOOD CANCER DATA 

3522
02:21:47,652 --> 02:21:51,756
INITIATIVE.  THIS NCI'S 

3523
02:21:51,756 --> 02:22:02,300
DR. BRIDGET WIDEMAN AND ED, SARA

3524
02:22:04,569 --> 02:22:07,605
LAER RI, ATTENDING PHYSICIAN AND

3525
02:22:07,605 --> 02:22:10,608
MEDICAL DIRECTOR.  PEDIATRIC 

3526
02:22:10,608 --> 02:22:12,710
BRAIN TUMOR PROGRAM.  UNIVERSITY

3527
02:22:12,710 --> 02:22:14,045
OF WASHINGTON SCHOOL OF MEDICINE

3528
02:22:14,045 --> 02:22:17,648
IN SEATTLE AND DIANE THOMAS.  

3529
02:22:17,648 --> 02:22:21,652
OPERATIONS DIRECTOR.  

3530
02:22:21,652 --> 02:22:25,089
ANATOMIC PATHOLOGY, NATIONWIDE 

3531
02:22:25,089 --> 02:22:26,556
CHILDREN'S HOSPITAL IN COLUMBUS.

3532
02:22:26,556 --> 02:22:28,058
>> THANK YOU SO MUCH FOR
THE 

3533
02:22:28,058 --> 02:22:30,660
INVITATION TO PRESENT AN UPDATE 

3534
02:22:30,660 --> 02:22:35,632
ON NCI'S DATA INITIATIVE.  IT 

3535
02:22:35,632 --> 02:22:38,301
STARTED IN 2020, AND I DON'T SEE

3536
02:22:38,301 --> 02:22:41,638
THE SLIDES ANYMORE, DO YOU SEE 

3537
02:22:41,638 --> 02:22:43,673
THEM?  LET ME SEE.  I DON'T SEE 

3538
02:22:43,673 --> 02:22:45,909
IT ON THE SCREEN HERE ANYMORE.  

3539
02:22:45,909 --> 02:22:49,045
BUT IT STARTED IN 2020.  AND 

3540
02:22:49,045 --> 02:22:52,282
SINCE THEN A LOT OF PROGRESS HAS

3541
02:22:52,282 --> 02:22:54,884
BEEN MADE.  AND DR. RATHMELL 

3542
02:22:54,884 --> 02:22:56,653
SUGGESTED FOR TODAY SO PRESENT 

3543
02:22:56,653 --> 02:22:59,623
YOU WITH SOME OF THE PROGRESS IN

3544
02:22:59,623 --> 02:23:05,128
HOW THE CCCDI HAS IMPACTED 

3545
02:23:05,128 --> 02:23:08,198
RESEARCH THAT HAS IMPACTED 

3546
02:23:08,198 --> 02:23:09,099
PEDIATRIC PATIENTS OF CANCER. 

3547
02:23:09,099 --> 02:23:12,269
THIS IS A COMBINED PRESENTATION 

3548
02:23:12,269 --> 02:23:15,038
OF MYSELF, ON BEHALF OF 

3549
02:23:15,038 --> 02:23:20,277
DR. RAYMOND AND DR. DIANA THOMAS

3550
02:23:20,277 --> 02:23:27,017
AND SARA LEERY.  I WILL GIVE AN 

3551
02:23:27,017 --> 02:23:28,218
UPDATE AND THEN THE OTHER 

3552
02:23:28,218 --> 02:23:30,954
DOCTORS WILL TALK ABOUT THE WORK

3553
02:23:30,954 --> 02:23:32,722
ON PEDIATRIC CENTRAL NERVOUS 

3554
02:23:32,722 --> 02:23:35,158
SYSTEM TUMORS AND I WILL END THE

3555
02:23:35,158 --> 02:23:36,159
PRESENTATION WITH AN OVERVIEW 

3556
02:23:36,159 --> 02:23:40,263
AND UPDATE ON THE RARE CANCER 

3557
02:23:40,263 --> 02:23:41,665
INITIATIVE.  I THINK THE CARTOON

3558
02:23:41,665 --> 02:23:44,100
ON THE RIGHT-HAND SIDE REALLY 

3559
02:23:44,100 --> 02:23:47,437
MOST BEAUTIFULLY SHOWS WHAT THE 

3560
02:23:47,437 --> 02:23:49,506
CCDI IS ABOUT.  TO BUILD A 

3561
02:23:49,506 --> 02:23:51,474
COMMUNITY AROUND RESEARCH DATA 

3562
02:23:51,474 --> 02:23:54,010
WITH THE ASPIRATIONAL GOAL TO 

3563
02:23:54,010 --> 02:23:56,279
LEARN FROM EVERY PATIENT WITH 

3564
02:23:56,279 --> 02:23:59,649
CANCER BUT ALSO TO BENEFIT EVERY

3565
02:23:59,649 --> 02:24:00,717
PATIENT ULTIMATELY.  WE HOPE TO 

3566
02:24:00,717 --> 02:24:02,686
DO SO BY GATHERING DATA FROM 

3567
02:24:02,686 --> 02:24:06,222
EVERY CHILD, CREATING A NATIONAL

3568
02:24:06,222 --> 02:24:07,023
STRATEGY FROM DIAGNOSIS TO 

3569
02:24:07,023 --> 02:24:08,858
TREATMENT AND DEVELOP A PLATFORM

3570
02:24:08,858 --> 02:24:11,361
AND TOOLS OF CLINICAL AND 

3571
02:24:11,361 --> 02:24:12,395
RESEARCH DATA TO IMPROVE 

3572
02:24:12,395 --> 02:24:15,298
TREATMENT QUALITY OF LIFE AND 

3573
02:24:15,298 --> 02:24:15,899
SURVIVORSHIP AND VERY 

3574
02:24:15,899 --> 02:24:18,868
IMPORTANTLY BY ENGAGING THE 

3575
02:24:18,868 --> 02:24:20,270
ENTIRE CHILDHOOD CANCER CARE AND

3576
02:24:20,270 --> 02:24:26,443
RESEARCH COMMUNITY.  THE CCDI 

3577
02:24:26,443 --> 02:24:30,146
HUB IS A VERY IMPORTANT ASPECT. 

3578
02:24:30,146 --> 02:24:33,083
THIS PROVIDES A PORTAL FOR 

3579
02:24:33,083 --> 02:24:33,850
RESEARCHERS BUT ANYONE 

3580
02:24:33,850 --> 02:24:36,286
INTERESTED IN LOOKING AT THE 

3581
02:24:36,286 --> 02:24:37,520
PEDIATRIC CANCER DATA THIS 

3582
02:24:37,520 --> 02:24:39,689
INFORMATION AND YOU SEE THE 

3583
02:24:39,689 --> 02:24:41,725
STATS HERE HAS VERY, VERY MANY 

3584
02:24:41,725 --> 02:24:43,093
DIFFERENT TYPES OF DATA THAT ARE

3585
02:24:43,093 --> 02:24:44,928
AVAILABLE TO RESEARCHERS TO 

3586
02:24:44,928 --> 02:24:46,930
ANALYZE, TO PROVIDE A SOURCE FOR

3587
02:24:46,930 --> 02:24:49,399
NEW DISCOVERIES THAT MAY IMPACT 

3588
02:24:49,399 --> 02:24:52,168
LIVES DOWN THE ROAD.  THE 

3589
02:24:52,168 --> 02:24:54,170
MOLECULAR CHARACTERIZATION 

3590
02:24:54,170 --> 02:24:56,272
INITIATIVE IS AN EFFORT FOR 

3591
02:24:56,272 --> 02:24:58,208
NATIONAL STRATEGY FOR 

3592
02:24:58,208 --> 02:25:00,243
APPROPRIATE CLINICAL AND 

3593
02:25:00,243 --> 02:25:01,644
MOLECULAR CHARACTERIZATION 

3594
02:25:01,644 --> 02:25:04,214
IDEALLY FOR EVERY CHILD WITH 

3595
02:25:04,214 --> 02:25:05,782
CANCER.  THE CCDI PROVIDES STATE

3596
02:25:05,782 --> 02:25:08,284
OF THE ART MOLECULAR 

3597
02:25:08,284 --> 02:25:09,586
CHARACTERIZATION FOR UP TO THREE

3598
02:25:09,586 --> 02:25:12,288
THOUSAND, THAT'S NOT ALL OF THE 

3599
02:25:12,288 --> 02:25:15,058
CHILDHOOD CANCER PATIENTS.  AND 

3600
02:25:15,058 --> 02:25:16,893
IN ADDITION, THERE'S A CLINICAL 

3601
02:25:16,893 --> 02:25:19,329
ANNOTATED BIOBANK FOR FUTURE 

3602
02:25:19,329 --> 02:25:21,231
RESEARCH FOR THE REMAINING 

3603
02:25:21,231 --> 02:25:24,267
TISSUE.  THIS IS A COLLABORATIVE

3604
02:25:24,267 --> 02:25:29,572
EFFORT BETWEEN THE NCI, THE CCDI

3605
02:25:29,572 --> 02:25:31,474
AND THE ONCOLOGY PRODUCT.THERE'S

3606
02:25:31,474 --> 02:25:34,077
A GROUP CALLED PROJECT EVERY 

3607
02:25:34,077 --> 02:25:35,145
CHILD. 

3608
02:25:35,145 --> 02:25:37,247
AND AS YOU CAN SEE ON THE 

3609
02:25:37,247 --> 02:25:39,215
CARTOON A CHILD WITH A NEWLY 

3610
02:25:39,215 --> 02:25:41,818
DIAGNOSED CANCER CAN ENROLL ON 

3611
02:25:41,818 --> 02:25:44,454
THE MOLECULAR PROTOCOL AND 

3612
02:25:44,454 --> 02:25:46,156
UNDERGO STATE OF THE ART 

3613
02:25:46,156 --> 02:25:48,491
SEQUENCING OF THE TUMOR, ALSO 

3614
02:25:48,491 --> 02:25:50,126
GERMLINE TESTING, VERY 

3615
02:25:50,126 --> 02:25:52,996
IMPORTANTLY THE RESULTS ARE 

3616
02:25:52,996 --> 02:25:53,797
RETURNED WITHIN TWO TO THREE 

3617
02:25:53,797 --> 02:25:55,632
WEEKS OF SUBMISSION OF THE 

3618
02:25:55,632 --> 02:25:59,702
SAMPLE TO THE TREATING 

3619
02:25:59,702 --> 02:26:01,070
PHYSICIAN.  THIS IMPACTS 

3620
02:26:01,070 --> 02:26:02,906
DIAGNOSIS AND TREATMENT AS YOU 

3621
02:26:02,906 --> 02:26:03,940
WILL SEE FROM THE OTHER DOCTORS 

3622
02:26:03,940 --> 02:26:05,942
IN A MOMENT.  ALL OF THIS DATA 

3623
02:26:05,942 --> 02:26:08,111
INCLUDING PATHOLOGY DATA AND 

3624
02:26:08,111 --> 02:26:10,980
CLINICAL DATA THAT COG COLLECTS 

3625
02:26:10,980 --> 02:26:15,585
GOES INTO THE DATA SYSTEM.  THE 

3626
02:26:15,585 --> 02:26:17,887
CCDI SYSTEM AND IS AVAILABLE FOR

3627
02:26:17,887 --> 02:26:20,890
ANALYSIS THE CCDI WAS INTRODUCED

3628
02:26:20,890 --> 02:26:25,462
IN 2022 AND SINCE THEN MORE THAN

3629
02:26:25,462 --> 02:26:27,464
3,000 PEDIATRIC BRAIN TUMORS 

3630
02:26:27,464 --> 02:26:31,701
HAVE ENROLLED.  RARE TUMORS AND 

3631
02:26:31,701 --> 02:26:34,270
YOU WILL SEE THE NEXT STEPS WILL

3632
02:26:34,270 --> 02:26:36,973
BE RELAPSE TUMORS AND THERE HAS 

3633
02:26:36,973 --> 02:26:38,675
BEEN A LOT OF WORK GOING INTO 

3634
02:26:38,675 --> 02:26:42,145
RELAPSE OF REMAINING SAMPLES.  I

3635
02:26:42,145 --> 02:26:47,784
WILL NOW HAPPENED IT OVER TO 

3636
02:26:47,784 --> 02:26:52,155
DOCTORS THOMAS AND LAER RI TO 

3637
02:26:52,155 --> 02:26:55,225
DISCUSS THE TUMORS AND SARA AND 

3638
02:26:55,225 --> 02:26:59,829
DIANA LET HE KNOW AS I SHOULD 

3639
02:26:59,829 --> 02:27:06,002
ADVANCE YOUR SLIDES.

3640
02:27:06,002 --> 02:27:08,605
>> THANK YOU FOR LETTING
ME SHOW

3641
02:27:08,605 --> 02:27:11,508
YOU THE INITIATIVES.  WE HOPE TO

3642
02:27:11,508 --> 02:27:14,477
HIGHLIGHT HOW NCI HAS IMPACTED 

3643
02:27:14,477 --> 02:27:18,548
THE ABLE TO APPROPRIATELY SDIEG 

3644
02:27:18,548 --> 02:27:22,852
YOUNG PEDIATRIC PATIENTS AS WELL

3645
02:27:22,852 --> 02:27:24,921
AS GUIDE CLINICAL TRIAL DESIGN. 

3646
02:27:24,921 --> 02:27:28,258
NEXT SLIDE, PLEASE.  ONE BACK, 

3647
02:27:28,258 --> 02:27:33,930
PLEASE.  CAN YOU PLEASE REVERSE 

3648
02:27:33,930 --> 02:27:35,398
ONE SLIDE?

3649
02:27:35,398 --> 02:27:35,832
>> SURE.

3650
02:27:35,832 --> 02:27:40,270
>> THANK YOU THE COG IS
ONE OF 

3651
02:27:40,270 --> 02:27:43,206
THE CLINICAL TRIAL NETWORKS 

3652
02:27:43,206 --> 02:27:45,542
INCLUDING 200 HOSPITALS 

3653
02:27:45,542 --> 02:27:46,709
INCLUDING CANADA AND NEW ZEALAND

3654
02:27:46,709 --> 02:27:54,117
AND THIS MAINTAINS A CHILDHOOD 

3655
02:27:54,117 --> 02:27:57,387
CANCER REGISTRY.  PATIENTS 

3656
02:27:57,387 --> 02:27:58,555
CONSENT AND ENROLL FOR 

3657
02:27:58,555 --> 02:28:00,223
PARTICIPATION IN THE NCI.  NEXT 

3658
02:28:00,223 --> 02:28:02,025
SLIDE, PLEASE.  THE DATA WE ARE 

3659
02:28:02,025 --> 02:28:05,828
GOING TO PRESENT TODAY INCLUDES 

3660
02:28:05,828 --> 02:28:08,031
2,170 PARTICIPANTS WITH CNS 

3661
02:28:08,031 --> 02:28:10,667
TUMORS THAT ENROLLED ON NCI 

3662
02:28:10,667 --> 02:28:12,569
BETWEEN THE LAUNCH IN MARCH OF 

3663
02:28:12,569 --> 02:28:15,038
2022 UNTIL THE COG CLINICAL DATA

3664
02:28:15,038 --> 02:28:21,010
FREEZE THAT OCCURRED IN DECEMBER

3665
02:28:21,010 --> 02:28:22,645
2023 OF THESE SUBJECTS THAT 

3666
02:28:22,645 --> 02:28:24,113
ENROLLED ABOUT HALF OF THESE 

3667
02:28:24,113 --> 02:28:27,116
PATIENTS WERE ENROLLED ON THE 

3668
02:28:27,116 --> 02:28:29,085
RIGHT.  YOU CAN SEE THAT LARGER 

3669
02:28:29,085 --> 02:28:30,720
INSTITUTIONS AND THE OTHER HALF 

3670
02:28:30,720 --> 02:28:32,255
WERE INSTITUTIONS WITH MUCH 

3671
02:28:32,255 --> 02:28:35,658
LOWER ENROLLMENTS AND THE CNS 

3672
02:28:35,658 --> 02:28:37,594
COHORT HAS CONTINUED TO GROW AND

3673
02:28:37,594 --> 02:28:41,564
NOW INCLUDES OVER 3,000 

3674
02:28:41,564 --> 02:28:43,499
PATIENTS.  NEXT, PLEASE.  

3675
02:28:43,499 --> 02:28:46,202
APPROXIMATELY 90% OF NCI 

3676
02:28:46,202 --> 02:28:47,303
PARTICIPANTS LIVE IN THE UNITED 

3677
02:28:47,303 --> 02:28:50,773
STATES.  AND THIS MAP HIGHLIGHTS

3678
02:28:50,773 --> 02:28:51,574
THE GEOGRAPHIC DISTRIBUTION OF 

3679
02:28:51,574 --> 02:28:53,810
U.S. PARTICIPANTS.  EACH SMALL 

3680
02:28:53,810 --> 02:28:55,311
WHITE DOT HERE IS AN INDIVIDUAL 

3681
02:28:55,311 --> 02:28:56,713
PARTICIPANT AND THE LARGER 

3682
02:28:56,713 --> 02:28:59,349
COLORED DOTS REPRESENT THE COG 

3683
02:28:59,349 --> 02:29:01,184
AFFILIATED HOSPITALS THAT ENROLL

3684
02:29:01,184 --> 02:29:02,719
THE PATIENTS.  AND IT'S 

3685
02:29:02,719 --> 02:29:05,888
INTERESTING TO SEE THE PATTERNS 

3686
02:29:05,888 --> 02:29:09,459
OF PARTICIPANTS IN MORE RURAL 

3687
02:29:09,459 --> 02:29:10,159
AREAS TRAVELLING TO RECEIVE CARE

3688
02:29:10,159 --> 02:29:16,265
AND ENROLL IN NCI.  NEXT, 

3689
02:29:16,265 --> 02:29:19,636
PLEASE.  THE CNS COHORT HAS A 

3690
02:29:19,636 --> 02:29:22,772
MEDIAN AGE OF CLOSE TO 9 YEARS 

3691
02:29:22,772 --> 02:29:24,540
WITH A SLIGHTLY MALE 

3692
02:29:24,540 --> 02:29:26,609
PREDOMINANCE AND RACE AND 

3693
02:29:26,609 --> 02:29:28,578
ETHNICITY ARE SUMMED UP ON THE 

3694
02:29:28,578 --> 02:29:31,247
RIGHT FOR PARTICIPANT WHO IS 

3695
02:29:31,247 --> 02:29:35,385
ENROLLED AT U.S. COG SITES AND 

3696
02:29:35,385 --> 02:29:39,055
ARE REMARKLY SIMILAR TO CENSUS 

3697
02:29:39,055 --> 02:29:41,391
RACE AND ETHNICITY DATA.  

3698
02:29:41,391 --> 02:29:46,596
NEXT, PLEADSSE.  THIS IS A 

3699
02:29:46,596 --> 02:29:52,268
BREAKDOWN OF THE CATEGORIES WITH

3700
02:29:52,268 --> 02:29:56,072
THE THESE.  AND THE CLINICAL 

3701
02:29:56,072 --> 02:29:56,939
TRIALS HAVE BEEN AVAILABLE FOR 

3702
02:29:56,939 --> 02:29:58,641
MANY OF THESE PATIENTS HOWEVER, 

3703
02:29:58,641 --> 02:30:02,445
IN ADDITION, THERE ARE ALSO MANY

3704
02:30:02,445 --> 02:30:09,252
RARE TUMORS IN THE NCI COHORT.  

3705
02:30:09,252 --> 02:30:11,454
NEXT, PLEASE.  SO TO PRACTICE 

3706
02:30:11,454 --> 02:30:17,660
PEDIATRIC PATHOLOGY IN 2024, WE 

3707
02:30:17,660 --> 02:30:21,964
MAKE AN INTEGRATED DIAGNOSIS AND

3708
02:30:21,964 --> 02:30:24,934
THESE ARE ALL PERFORMED IN A 

3709
02:30:24,934 --> 02:30:27,170
CERTIFIED SETTING AND INCLUDE 

3710
02:30:27,170 --> 02:30:28,471
DNA METHYLATION, DNA SEQUENCING 

3711
02:30:28,471 --> 02:30:32,475
AND FUSION PANEL.  ALL OF THE 

3712
02:30:32,475 --> 02:30:34,877
PATIENTS, THE CNS PATIENTS WHO 

3713
02:30:34,877 --> 02:30:36,813
HAVE RECEIVED NCI TESTING TO 

3714
02:30:36,813 --> 02:30:38,781
DATE HAVE RECEIVED CLINICAL 

3715
02:30:38,781 --> 02:30:40,283
REPORTS WITH AT LEAST ONE 

3716
02:30:40,283 --> 02:30:41,117
CLINICALLY MEANINGFUL RESULT 

3717
02:30:41,117 --> 02:30:43,986
THAT I TRY TO SUMMARIZE INTO A 

3718
02:30:43,986 --> 02:30:46,723
SINGLE SLIDE HERE BY THE MAIN 

3719
02:30:46,723 --> 02:30:48,157
POINT IS THE BROAD 

3720
02:30:48,157 --> 02:30:49,459
CHARACTERIZATION DONE THROUGH 

3721
02:30:49,459 --> 02:30:53,629
NCI ALLOWS US TO NOT MISS RARE 

3722
02:30:53,629 --> 02:30:54,197
DIAGNOSES THAT FOR EXAMPLE 

3723
02:30:54,197 --> 02:30:55,698
REQUIRE METHYLATION PROFILING 

3724
02:30:55,698 --> 02:30:58,367
FOR DEFINITIVE CLASSIFICATION.  

3725
02:30:58,367 --> 02:31:00,269
WHILE ALSO FURTHER REFINING 

3726
02:31:00,269 --> 02:31:03,639
DIAGNOSES FOR ACCURATE RISK 

3727
02:31:03,639 --> 02:31:04,941
STRATIFICATION AND THERAPY 

3728
02:31:04,941 --> 02:31:10,613
SELECTION.  NEXT, PLEASE.  APART

3729
02:31:10,613 --> 02:31:13,349
FROM THE SEMITIC DIAGNOSTIC 

3730
02:31:13,349 --> 02:31:16,552
TESTING NCI INCLUDES GERMLINE 

3731
02:31:16,552 --> 02:31:17,553
TESTING FOR ADDITIONAL SCREENING

3732
02:31:17,553 --> 02:31:20,223
FOR PATIENTS AND THEIR FAMILIES.

3733
02:31:20,223 --> 02:31:22,658
APPROXIMATELY 12% OF PATIENTS 

3734
02:31:22,658 --> 02:31:24,260
TESTED SO FAR HAVE BEEN FOUND TO

3735
02:31:24,260 --> 02:31:29,265
HAVE GENETIC PREDISPOSITION 

3736
02:31:29,265 --> 02:31:31,400
INVOLVING 49 DIFFERENT GENES AND

3737
02:31:31,400 --> 02:31:35,972
EVEN THE MOST COMMON GENES HAVE 

3738
02:31:35,972 --> 02:31:37,340
GERMLINE MUTATIONS INDICATE 

3739
02:31:37,340 --> 02:31:40,977
THING BROAD TESTING APPROACH IS 

3740
02:31:40,977 --> 02:31:41,978
IMPORTANT TO IDENTIFY MANY OF 

3741
02:31:41,978 --> 02:31:44,280
THESE GENES AND MORE FOCUSSED 

3742
02:31:44,280 --> 02:31:46,482
TESTING THROUGH IMMEW IN THIS 

3743
02:31:46,482 --> 02:31:48,017
CASIC CHEMISTRY WOULD HAVE 

3744
02:31:48,017 --> 02:31:52,255
MISSED THESE RESULTS.  

3745
02:31:52,255 --> 02:31:58,094
NEXT, PLEASE.  THE NCI CNS DATA 

3746
02:31:58,094 --> 02:31:59,295
ALSO INCLUDES SITE FOLLOW UP ON 

3747
02:31:59,295 --> 02:32:00,196
PARTICIPANTS.  AND AS YOU CAN 

3748
02:32:00,196 --> 02:32:03,833
SEE A LARGE PROPORTION OF SITES 

3749
02:32:03,833 --> 02:32:07,970
HAVE CONFIRMED THAT NCI TESTING 

3750
02:32:07,970 --> 02:32:09,005
HAS HELPED REFINE THEIR 

3751
02:32:09,005 --> 02:32:09,672
DIAGNOSIS AND ON THE SEQUENCING 

3752
02:32:09,672 --> 02:32:14,143
RESULTS.  NCI RESULTS ARE ALSO 

3753
02:32:14,143 --> 02:32:17,446
BEING USED FOR CLINICAL TRIAL 

3754
02:32:17,446 --> 02:32:20,283
ENROLLMENT AND ABOUT 7% THESE 

3755
02:32:20,283 --> 02:32:21,684
NUMBERS INDICATE IN PART THE 

3756
02:32:21,684 --> 02:32:25,354
VERY LARGE COHORT OF CHILDREN 

3757
02:32:25,354 --> 02:32:27,590
INCLUDED IN CNI WITH RARE 

3758
02:32:27,590 --> 02:32:28,825
DIAGNOSIS FOR WHICH TRIALS ARE 

3759
02:32:28,825 --> 02:32:30,693
NOT AVAILABLE AND AS WE KNOW 

3760
02:32:30,693 --> 02:32:32,595
CURRENTLY WE ARE IN A PERIOD OF 

3761
02:32:32,595 --> 02:32:34,063
TRANSITION IN WHICH MOLECULAR 

3762
02:32:34,063 --> 02:32:36,032
INFORMATION IS BEING 

3763
02:32:36,032 --> 02:32:38,167
INCORPORATED INTO TRIAL DESIGN. 

3764
02:32:38,167 --> 02:32:40,002
AND WITH THAT, I WILL HAND IT 

3765
02:32:40,002 --> 02:32:44,207
OVER TO DR. LEARY TO DISCUSS THE

3766
02:32:44,207 --> 02:32:47,910
USE OF THESE DATA AND CURRENT 

3767
02:32:47,910 --> 02:32:49,412
AND FUTURE CLINICAL TRIAL 

3768
02:32:49,412 --> 02:32:49,645
DESIGN.

3769
02:32:49,645 --> 02:32:51,047
>> THANK YOU VERY MUCH FOR

3770
02:32:51,047 --> 02:32:52,615
HAVING ME AND SO I'M GOING TO 

3771
02:32:52,615 --> 02:32:54,050
SPEAK BOTH AS A CLINICAL 

3772
02:32:54,050 --> 02:32:58,254
TRIALIST AND I WORK ON THE CNS 

3773
02:32:58,254 --> 02:33:00,089
COMMITTEE IN ONCOLOGY TO DEVELOP

3774
02:33:00,089 --> 02:33:05,194
A COHORT OF TRIALS FOR TUMORS 

3775
02:33:05,194 --> 02:33:07,964
AND ALSO AS A PRACTICING 

3776
02:33:07,964 --> 02:33:12,134
CLINICIAN IN MY OWN BRAIN TUMOR 

3777
02:33:12,134 --> 02:33:14,637
CLINIC AT SEATTLE'S CHILDREN.  

3778
02:33:14,637 --> 02:33:17,506
MED YOU LOW BLASTOMA IS ONE OF 

3779
02:33:17,506 --> 02:33:20,176
THE LARGEST PROPORTION OF TUMORS

3780
02:33:20,176 --> 02:33:21,911
AND THE MOST COMMON MALIGNANT 

3781
02:33:21,911 --> 02:33:23,779
TUMOR IN CHILDREN AND A PERFECT 

3782
02:33:23,779 --> 02:33:25,381
EXAMPLE OF WHY WE NEED THIS 

3783
02:33:25,381 --> 02:33:26,983
TESTING FOR BOTH CLINICAL 

3784
02:33:26,983 --> 02:33:29,085
DIAGNOSES AND CLINICAL TRIAL 

3785
02:33:29,085 --> 02:33:29,318
DESIGN. 

3786
02:33:29,318 --> 02:33:32,288
WE NOW UNDERSTAND THAT THIS 

3787
02:33:32,288 --> 02:33:38,261
TUMOR IS FOR DISTINCT MOLECULAR 

3788
02:33:38,261 --> 02:33:42,131
GROUPS WHICH REQUIRE TESTING TO 

3789
02:33:42,131 --> 02:33:43,266
CHARACTERIZE AND BEYOND 

3790
02:33:43,266 --> 02:33:45,067
DIAGNOSIS THE REGULAR TESTING IS

3791
02:33:45,067 --> 02:33:48,137
NEEDED FOR RISK STRATIFICATION. 

3792
02:33:48,137 --> 02:33:50,573
MEANING SELECTING PATIENTS 

3793
02:33:50,573 --> 02:33:52,909
THAT -- WHERE WE CAN SAFELY 

3794
02:33:52,909 --> 02:33:56,279
REDUCE CYTOTOXIC THERAPY AND THE

3795
02:33:56,279 --> 02:33:59,248
LONG-TERM IMPLICATIONS OF TOXIC 

3796
02:33:59,248 --> 02:34:01,751
THERAPY AND SIDE EFFECTS AND 

3797
02:34:01,751 --> 02:34:03,953
ALSO HIGH RISK GROUPS WHERE WE 

3798
02:34:03,953 --> 02:34:06,122
NEED TO GIVE THE INTENSIVE 

3799
02:34:06,122 --> 02:34:07,456
THERAPY TO ACHIEVE CURE AND SO 

3800
02:34:07,456 --> 02:34:09,992
IF YOU CAN MOVE TO THE NEXT 

3801
02:34:09,992 --> 02:34:11,861
SLIDE I WILL SHOW THE EXAMPLE OF

3802
02:34:11,861 --> 02:34:14,630
WHAT WE DO WITH MED YOU LOW 

3803
02:34:14,630 --> 02:34:16,799
BLASTOMA FOR RISK 

3804
02:34:16,799 --> 02:34:18,701
STRATIFICATION.  WE USE CLINICAL

3805
02:34:18,701 --> 02:34:19,702
RISK FACTORS AS WELL AS 

3806
02:34:19,702 --> 02:34:24,140
MOLECULAR RISK FACTORS TO 

3807
02:34:24,140 --> 02:34:28,277
PERFECTLY CATEGORIZE TUMORS FOR 

3808
02:34:28,277 --> 02:34:33,115
BRAIN INTENSIVE THERAPY.  FOR 

3809
02:34:33,115 --> 02:34:34,617
THE GROUP, IF YOU CAN ADVANCE 

3810
02:34:34,617 --> 02:34:39,689
THE SLIDES, PLEASE, THE DNA 

3811
02:34:39,689 --> 02:34:40,289
METHYLATION TESTS IS THE TEST 

3812
02:34:40,289 --> 02:34:43,426
THAT BEST DESCRIBES THE FOUR 

3813
02:34:43,426 --> 02:34:52,268
GROUPS.  SEQUENCING IS USED AND 

3814
02:34:52,268 --> 02:34:54,170
ALL OF THIS INFORMATION IS 

3815
02:34:54,170 --> 02:34:59,342
REQUIRED TO MAKE A DIAGNOSIS.  

3816
02:34:59,342 --> 02:35:01,677
AND APPROPRIATELY RISK STRATIFY 

3817
02:35:01,677 --> 02:35:04,280
PATIENTS FOR THERAPY OF MED YOU 

3818
02:35:04,280 --> 02:35:07,383
LOW BLASTOMA WHETHER ON OR OFF 

3819
02:35:07,383 --> 02:35:08,117
TRIAL.  AND WE HAVE THE CURRENT 

3820
02:35:08,117 --> 02:35:09,819
TRIALS THAT WE HAVE IN THE 

3821
02:35:09,819 --> 02:35:11,554
CHILDREN'S ONCOLOGY GROUP.  WE 

3822
02:35:11,554 --> 02:35:14,023
HAVE THE MED YOU LOW BLASTOMA 

3823
02:35:14,023 --> 02:35:16,192
OPENED FOR LOW AND AT RISK.  AND

3824
02:35:16,192 --> 02:35:19,628
THERE ARE TWO STUDIES FOR HIGH 

3825
02:35:19,628 --> 02:35:22,331
RISK DISEASE.  AND SO THIS IS 

3826
02:35:22,331 --> 02:35:24,400
CERTAINLY THE MOST COMPLICATED 

3827
02:35:24,400 --> 02:35:26,035
RISK STRATIFICATION AND WE HAVE 

3828
02:35:26,035 --> 02:35:28,971
THEREFORE REQUIRED MOLECULAR 

3829
02:35:28,971 --> 02:35:29,772
CHARACTERIZATION PARTICIPATION 

3830
02:35:29,772 --> 02:35:32,708
BECAUSE IT REALLY IS THE ONLY 

3831
02:35:32,708 --> 02:35:37,313
TEST TO GET CONSISTENT BROAD 

3832
02:35:37,313 --> 02:35:38,948
INFORMATION THAT WE NEED FOR 

3833
02:35:38,948 --> 02:35:40,750
DESIGN.  WHAT I WILL POINT OUT 

3834
02:35:40,750 --> 02:35:43,619
IS THAT THE CHILDREN THAT WE SEE

3835
02:35:43,619 --> 02:35:45,254
IN THE FIRST MONTHS DID NOT GO 

3836
02:35:45,254 --> 02:35:47,256
ON TRIAL.  THE TRIALS WEREN'T 

3837
02:35:47,256 --> 02:35:49,925
YET OPEN WHEN WE OPENED THE NC I

3838
02:35:49,925 --> 02:35:51,861
BUT WE SEE BASED ON THOSE 

3839
02:35:51,861 --> 02:35:54,296
NUMBERS THAT EVEN IN THE FIRST 

3840
02:35:54,296 --> 02:35:55,564
YEAR MORE THAN HALF OF THE 

3841
02:35:55,564 --> 02:35:57,867
CHILDREN ARE USING THE NCI FOR 

3842
02:35:57,867 --> 02:35:59,635
THEIR CLINICAL TESTING AND THEY 

3843
02:35:59,635 --> 02:36:01,270
WILL EXPAND AS MORE TRIALS ARE 

3844
02:36:01,270 --> 02:36:03,305
AVAILABLE AND AS MORE SITES 

3845
02:36:03,305 --> 02:36:04,740
REALIZE WHAT A VALUE IT IS TO 

3846
02:36:04,740 --> 02:36:06,909
THEM.  IN OTHER TRIALS THAT WE 

3847
02:36:06,909 --> 02:36:10,212
HAVE OPEN, ARE LESS COMPLICATED 

3848
02:36:10,212 --> 02:36:13,449
BUT NO LESS RELIANT ON THE LACK 

3849
02:36:13,449 --> 02:36:14,917
OF CHARACTERIZATION AND BOTH 

3850
02:36:14,917 --> 02:36:16,452
HIGH GRADE AND LOW GRADE WE HAVE

3851
02:36:16,452 --> 02:36:18,287
TRIALS OF KINASE INHIBITOR 

3852
02:36:18,287 --> 02:36:20,056
THERAPY THAT ARE OPEN AND THESE 

3853
02:36:20,056 --> 02:36:21,957
REQUIRE BOTH POSITIVE AND 

3854
02:36:21,957 --> 02:36:23,192
NEGATIVE SELECTIONS OF THE 

3855
02:36:23,192 --> 02:36:25,061
PRESENCE OR ABSENCE OF SPECIFIC 

3856
02:36:25,061 --> 02:36:26,762
GENES WITHIN BOTH HIGH AND LOW 

3857
02:36:26,762 --> 02:36:30,299
GRADE GLEE OWE MA.  NEXT SLIDE, 

3858
02:36:30,299 --> 02:36:30,866
PLEASE.  

3859
02:36:30,866 --> 02:36:32,268
ANOTHER DISEASE THAT I WOULD 

3860
02:36:32,268 --> 02:36:40,376
LIKE TO SPEAK ABOUT UNLIKE MED 

3861
02:36:40,376 --> 02:36:42,978
YOU LOW BLASTOMA.  IN DIFFUSE, 

3862
02:36:42,978 --> 02:36:46,215
THIS IS ONE OF THE LAST 

3863
02:36:46,215 --> 02:36:48,117
REMAINING TRULY INCURABLE 

3864
02:36:48,117 --> 02:36:49,885
CANCERS.  WE KNOW IT'S DEFINED 

3865
02:36:49,885 --> 02:36:52,121
BY A MUTATION IN THE HIS TOME 

3866
02:36:52,121 --> 02:36:56,258
GENE, THAT INFORMATION CAME FROM

3867
02:36:56,258 --> 02:36:58,227
AUTOPSY STUDIES IN THE FAST BUT 

3868
02:36:58,227 --> 02:36:59,595
ADVANCING SURGICAL TECHNIQUE 

3869
02:36:59,595 --> 02:37:02,498
EVEN WITH THESE TUMORS THAT CAN 

3870
02:37:02,498 --> 02:37:06,268
OFTEN BE DIAGNOSED NOW WITH 

3871
02:37:06,268 --> 02:37:07,636
MOLECULAR CHARACTERIZATION AND 

3872
02:37:07,636 --> 02:37:11,006
BIOPSY AT DIAGNOSIS.  AND WE SEE

3873
02:37:11,006 --> 02:37:14,009
THROUGH THE NCI THAT WE 

3874
02:37:14,009 --> 02:37:15,945
ACTUALLY, THIS IS THE MOST 

3875
02:37:15,945 --> 02:37:18,047
COMMON HIGH GRADE GLIOMA THAT WE

3876
02:37:18,047 --> 02:37:22,618
SEE IN PEDIATRICS AS EXPECTED 

3877
02:37:22,618 --> 02:37:23,652
AND THE -- WE ALSO UNFORTUNATELY

3878
02:37:23,652 --> 02:37:27,556
SEE AS WE START TO GET FOLLOW UP

3879
02:37:27,556 --> 02:37:29,191
DATA NOW THAT THE SURVIVAL IS 

3880
02:37:29,191 --> 02:37:32,895
SMALL AS WE KNOW WITH OVER HALF 

3881
02:37:32,895 --> 02:37:38,033
OF THE CHILDREN IN THE FIRST 

3882
02:37:38,033 --> 02:37:48,577
YEAR OF DIAGNOSIS SUCCUMBING AND

3883
02:37:49,078 --> 02:37:51,213
THE REST IN YEAR THREE AND ALL 

3884
02:37:51,213 --> 02:37:53,816
THE TUMORS HAVE ADDITIONAL 

3885
02:37:53,816 --> 02:37:56,285
MUTATIONS AND THOSE MUTATIONS 

3886
02:37:56,285 --> 02:38:00,089
ARE TARGETABLE WITH THERAPIES 

3887
02:38:00,089 --> 02:38:01,123
THAT ALREADY EXIST FOR OTHER 

3888
02:38:01,123 --> 02:38:03,592
DISEASES.  THE CURRENT STUDIES 

3889
02:38:03,592 --> 02:38:04,693
WE HAVE OPEN ARE ACTUALLY FOR 

3890
02:38:04,693 --> 02:38:08,464
LESS THAN 5% OF THIS DIAGNOSIS. 

3891
02:38:08,464 --> 02:38:14,036
WE HAVE THE TRIAL OPEN FOR V 600

3892
02:38:14,036 --> 02:38:16,272
THERAPY AND WE DO SEE THAT THE 

3893
02:38:16,272 --> 02:38:20,276
MUTATIONS CO-OCCUR WITH THE 

3894
02:38:20,276 --> 02:38:23,145
DIFFUSE GLIOMA BUT WE ALSO SEE 

3895
02:38:23,145 --> 02:38:27,416
OTHER MULTIPLE MUTATIONS WITHIN 

3896
02:38:27,416 --> 02:38:29,185
THE PATHWAY WHICH ARE 

3897
02:38:29,185 --> 02:38:31,587
THERAPEUTIC INDICATIONS.  IF YOU

3898
02:38:31,587 --> 02:38:32,988
ADVANCE TO THE NEXT SLIDE.  THIS

3899
02:38:32,988 --> 02:38:35,524
IS NOT COMPREHENSIVE BUT MY OWN 

3900
02:38:35,524 --> 02:38:38,594
INITIAL ANALYSIS AS WE LOOK AT 

3901
02:38:38,594 --> 02:38:40,062
THE RESULTS FOR NCI BUT THERE 

3902
02:38:40,062 --> 02:38:42,398
ARE MULTIPLE OTHER MUTATIONS 

3903
02:38:42,398 --> 02:38:49,838
THAT OCCUR IN THE 5-10% RANGE 

3904
02:38:49,838 --> 02:38:51,507
WHICH ALL HAVE THERAPEUTIC 

3905
02:38:51,507 --> 02:38:52,575
IMPLICATIONS.  ONE OF THE THINGS

3906
02:38:52,575 --> 02:38:54,210
THAT WAS PARTICULARLY 

3907
02:38:54,210 --> 02:38:59,782
INTERESTING TO ME IS THAT WE SAW

3908
02:38:59,782 --> 02:39:03,052
EFFUSIONS IN 7-8 PATIENTS WHICH 

3909
02:39:03,052 --> 02:39:05,254
ARE CLEAR IMPLICATIONS TO 

3910
02:39:05,254 --> 02:39:07,856
THERAPEUTICS AND THAT'S 

3911
02:39:07,856 --> 02:39:10,526
IMPORTANT TO ME AS A CLINICIAN 

3912
02:39:10,526 --> 02:39:13,696
BECAUSE THAT'S NOT EVEN A TEST 

3913
02:39:13,696 --> 02:39:16,599
WAS ROUTINELY RECOMMENDED IN 

3914
02:39:16,599 --> 02:39:18,968
HIGH GRADE GLIOMA BUT WE DO 

3915
02:39:18,968 --> 02:39:21,237
IDENTIFY THE OUTLIERS AND THESE 

3916
02:39:21,237 --> 02:39:23,138
TEST RESULTS CERTAINLY MAY 

3917
02:39:23,138 --> 02:39:24,940
MATTER TO THESE PATIENTS AND AS 

3918
02:39:24,940 --> 02:39:28,711
DR. THOMAS MENTIONED, ACROSS 

3919
02:39:28,711 --> 02:39:31,747
PEDIATRIC TUMORS WE SEE THE 

3920
02:39:31,747 --> 02:39:32,381
APPLICATIONS FOR THE PATIENT AND

3921
02:39:32,381 --> 02:39:38,621
THEIR FAMILIES INCLUDING THE 

3922
02:39:38,621 --> 02:39:40,289
PATIENTS WHICH HAVE CHECKPOINT 

3923
02:39:40,289 --> 02:39:42,758
AND IMMUNOTHERAPY.  SO THIS IS 

3924
02:39:42,758 --> 02:39:44,260
REALLY MADE US THINK AND NEXT 

3925
02:39:44,260 --> 02:39:49,932
SLIDE, PLEASE, ABOUT 

3926
02:39:49,932 --> 02:39:52,968
IMPLICATIONS FOR HOW WE DIAGNOSE

3927
02:39:52,968 --> 02:39:54,770
AND TREAT CHILDREN AND HOW WE 

3928
02:39:54,770 --> 02:39:56,538
DESIGN CLINICAL RESEARCH TO 

3929
02:39:56,538 --> 02:39:58,607
ASSESS NOVEL THERAPEUTICS.  

3930
02:39:58,607 --> 02:40:03,312
THERE ARE STUDIES BUILDING ON 

3931
02:40:03,312 --> 02:40:04,847
THIS NOW TO LOOK AT THE 

3932
02:40:04,847 --> 02:40:06,315
PREDISPOSITION AND THEIR 

3933
02:40:06,315 --> 02:40:07,716
FAMILIES.  WE'RE LOOKING TO 

3934
02:40:07,716 --> 02:40:09,485
CONNECT TO OTHER ROBUST CLINICAL

3935
02:40:09,485 --> 02:40:11,620
DATA SOURCES.  I CERTAINLY HOPE 

3936
02:40:11,620 --> 02:40:14,757
THERE IS MORE GENOMIC DISCOVERY 

3937
02:40:14,757 --> 02:40:16,692
TO COME AND IT DOES GIVE US AN 

3938
02:40:16,692 --> 02:40:18,427
OPPORTUNITY TO THINK MORE ABOUT 

3939
02:40:18,427 --> 02:40:21,130
CLINICAL RESEARCH IN ULTRA RARE 

3940
02:40:21,130 --> 02:40:24,266
TUMOR POPULATIONS.  WITH THAT, I

3941
02:40:24,266 --> 02:40:30,472
WILL PASS IT BACK OVER TO 

3942
02:40:30,472 --> 02:40:33,642
DR. WIDEMAN TO TALK ABOUT THAT 

3943
02:40:33,642 --> 02:40:35,711
AND I WOULD LIKE TO THANK THE 

3944
02:40:35,711 --> 02:40:36,278
TREMENDOUS AMOUNT OF 

3945
02:40:36,278 --> 02:40:37,780
COLLABORATION.  SORRY, ONE MORE 

3946
02:40:37,780 --> 02:40:38,814
SLIDE AND HIGHLIGHTING A FEW OF 

3947
02:40:38,814 --> 02:40:40,849
THE PEOPLE THAT HAVE HELPED 

3948
02:40:40,849 --> 02:40:44,520
DR. THOMAS AND ME BOTH FROM THE 

3949
02:40:44,520 --> 02:40:45,888
STATISTICIAN SIDE AND TO PUT 

3950
02:40:45,888 --> 02:40:47,523
TOGETHER SOME OF THE FIGURES AND

3951
02:40:47,523 --> 02:40:52,261
THE DATA PRESENTED TODAY.  THANK

3952
02:40:52,261 --> 02:40:53,929
YOU

3953
02:40:53,929 --> 02:40:54,096
YOU.

3954
02:40:54,096 --> 02:40:55,097
>> THANK YOU SO MUCH DIANA
AND 

3955
02:40:55,097 --> 02:40:58,667
SARA AND YOU MADE IT SO CLEAR 

3956
02:40:58,667 --> 02:41:00,269
HOW COMPLICATED THE TREATMENT IS

3957
02:41:00,269 --> 02:41:04,273
AND HOW MUCH MOLECULAR CHARA

3958
02:41:04,273 --> 02:41:07,376
CHARACTERIZATION AND NEED AND IT

3959
02:41:07,376 --> 02:41:09,478
WAS SAID THAT EVERY TUMOR IS A 

3960
02:41:09,478 --> 02:41:11,180
RARE TUMOR AND IS REALLY TRUE 

3961
02:41:11,180 --> 02:41:13,549
AND DESERVES THIS TYPE OF 

3962
02:41:13,549 --> 02:41:14,650
CHARACTERIZATION.  I WOULD LIKE 

3963
02:41:14,650 --> 02:41:16,285
TO GIVE YOU A BRIEF UPDATE NOW 

3964
02:41:16,285 --> 02:41:20,289
AND OUR CCDI COORDINATED 

3965
02:41:20,289 --> 02:41:27,830
PEDIATRIC AND  ADOLESCENT CARE 

3966
02:41:27,830 --> 02:41:29,331
INITIATIVE.  THIS IS BUILDING ON

3967
02:41:29,331 --> 02:41:32,267
WHAT SARA WAS ELUDING TO FOR 

3968
02:41:32,267 --> 02:41:36,071
PATIENTS WHO HAVE ULTRA RARE 

3969
02:41:36,071 --> 02:41:37,473
TUMORS.  LESS THAN TWO MILLION A

3970
02:41:37,473 --> 02:41:39,375
YEAR AND PATIENTS WHERE THE 

3971
02:41:39,375 --> 02:41:40,242
STANDARD OF CARE DOESN'T EXIST 

3972
02:41:40,242 --> 02:41:43,679
WHERE CLINICAL TRIALS ARE NOT 

3973
02:41:43,679 --> 02:41:45,214
FEASIBLE.  AND WE KNOW MANY 

3974
02:41:45,214 --> 02:41:46,715
INDIVIDUAL EFFORTS ARE ONGOING 

3975
02:41:46,715 --> 02:41:48,951
BUT WE HAVE PROBABLY TWO OR 

3976
02:41:48,951 --> 02:41:51,220
THREE HUNDRED ALREADY KNOWN RARE

3977
02:41:51,220 --> 02:41:53,255
PEDIATRIC TUMORS AND HOW DO WE 

3978
02:41:53,255 --> 02:41:54,556
MAKE PROGRESS?  SO WE ARE 

3979
02:41:54,556 --> 02:41:57,926
DEVELOPING AS YOU NOW A CCDI 

3980
02:41:57,926 --> 02:42:00,396
COORDINATED EFFORT THAT WILL 

3981
02:42:00,396 --> 02:42:03,298
PROVIDE THE INFRASTRUCTURE TO 

3982
02:42:03,298 --> 02:42:05,701
SIMULTANEOUSLY STUDY MULTIPLE 

3983
02:42:05,701 --> 02:42:07,436
RARE TUMORS THIS WILL BE A 

3984
02:42:07,436 --> 02:42:10,973
FEASIBILITY OF A NATIONAL 

3985
02:42:10,973 --> 02:42:12,541
OBSERVATIONAL STUDY FOR CHILDREN

3986
02:42:12,541 --> 02:42:17,846
AND THOSE ADULTS WITH RARE 

3987
02:42:17,846 --> 02:42:20,983
TUMORS LONGITUDINALLY.  WHAT YOU

3988
02:42:20,983 --> 02:42:23,218
HEARD ABOUT THE CHARACTERIZATION

3989
02:42:23,218 --> 02:42:23,886
INITIATIVE.  THESE PATIENT 

3990
02:42:23,886 --> 02:42:26,488
CONSIST COME FROM INSTITUTIONS 

3991
02:42:26,488 --> 02:42:27,790
BUT ANY INSTITUTION ANYWHERE IN 

3992
02:42:27,790 --> 02:42:28,490
THE COUNTRY. 

3993
02:42:28,490 --> 02:42:32,261
SO WE HOPE TO GET TO PATIENTS 

3994
02:42:32,261 --> 02:42:33,095
WITH CANCERS THAT WOULD 

3995
02:42:33,095 --> 02:42:34,463
OTHERWISE NOT HAVE ACCESS TO 

3996
02:42:34,463 --> 02:42:41,170
THIS TESTING.  WE WILL COLLECT 

3997
02:42:41,170 --> 02:42:42,337
PROSPECTIVELY IMAGING AND 

3998
02:42:42,337 --> 02:42:44,973
PATHOLOGY.  THE MOLECULAR 

3999
02:42:44,973 --> 02:42:45,874
CHARACTERIZATION WILL GO THROUGH

4000
02:42:45,874 --> 02:42:48,110
THE INITIATIVE THAT SARA AND 

4001
02:42:48,110 --> 02:42:50,512
DIANA JUST PROTECTED TO YOU.  

4002
02:42:50,512 --> 02:42:52,281
HOWEVER THERE'LL BE ALSO 

4003
02:42:52,281 --> 02:42:54,349
RESEARCH MOLECULAR TESTING.  WE 

4004
02:42:54,349 --> 02:42:56,018
WORK A LOT ON IDENTIFYING WHAT 

4005
02:42:56,018 --> 02:42:58,420
COMMON DATA ELEMENTS DO WE WANT 

4006
02:42:58,420 --> 02:42:59,621
TO COLLECT ON EVERY PATIENT 

4007
02:42:59,621 --> 02:43:02,491
ACROSS ALL OF THE COHORTS AND WE

4008
02:43:02,491 --> 02:43:05,994
WILL ALSO INCORPORATE PATIENT 

4009
02:43:05,994 --> 02:43:07,396
REPORTED OUTCOMES.  WE HOPE THAT

4010
02:43:07,396 --> 02:43:10,766
THE STATE OF THE ART CLINICAL 

4011
02:43:10,766 --> 02:43:12,234
AND RESEARCH MOLECULAR 

4012
02:43:12,234 --> 02:43:12,534
PROFILING. 

4013
02:43:12,534 --> 02:43:14,336
WILL ALLOW US TO MAKE BETTER 

4014
02:43:14,336 --> 02:43:16,772
TREATMENT RECOMMENDATIONS AND I 

4015
02:43:16,772 --> 02:43:19,675
THINK SARA AND DIANA GAVE YOU AN

4016
02:43:19,675 --> 02:43:21,543
EXAMPLE OF HOW THIS WILL BE 

4017
02:43:21,543 --> 02:43:22,211
REPRESENTED THROUGH THE 

4018
02:43:22,211 --> 02:43:24,012
CHARACTERIZATION BUT ALSO 

4019
02:43:24,012 --> 02:43:25,514
HOPEFULLY IDENTIFY NEW TARGETS, 

4020
02:43:25,514 --> 02:43:26,982
INFORM NEW TREATMENT TRIALS, 

4021
02:43:26,982 --> 02:43:29,852
WILL ALLOW FOR MEANINGFUL 

4022
02:43:29,852 --> 02:43:32,020
COMPARISON ACROSS RARE CANCER 

4023
02:43:32,020 --> 02:43:35,224
TYPES, POTENTIALLY BE A SOURCE 

4024
02:43:35,224 --> 02:43:36,258
FOR EXTERNAL CONTROL FOR TRIALS 

4025
02:43:36,258 --> 02:43:38,794
WHEN RANDOMIZATION IS NOT 

4026
02:43:38,794 --> 02:43:41,063
FEASIBLE AND THE REGISTRY OF 

4027
02:43:41,063 --> 02:43:41,930
STRUCTURED AND REAL WORLD DATA 

4028
02:43:41,930 --> 02:43:44,766
WILL HOPEFULLY INFORM NEW TRIAL 

4029
02:43:44,766 --> 02:43:48,570
DESIGNS.  WE VERY RECENTLY HAD A

4030
02:43:48,570 --> 02:43:50,372
CCDI SUPPORTED WORKSHOP HERE AT 

4031
02:43:50,372 --> 02:43:52,174
THE SAME PLACE WHERE WE ARE 

4032
02:43:52,174 --> 02:43:54,510
TODAY.  WE HAD MULTIDISCIPLINARY

4033
02:43:54,510 --> 02:43:55,978
PARTICIPATION FROM WITHIN AND 

4034
02:43:55,978 --> 02:43:58,747
OUTSIDE OF THE COG DATA 

4035
02:43:58,747 --> 02:44:00,382
SCIENTISTS AND CLINICIANS AND 

4036
02:44:00,382 --> 02:44:03,252
HONED DOWN ON THESE DATA TYPES 

4037
02:44:03,252 --> 02:44:05,354
AND I THINK CAME TO VERY GOOD 

4038
02:44:05,354 --> 02:44:06,989
AGREEMENT OF THE DATA THAT WE 

4039
02:44:06,989 --> 02:44:09,224
REALLY WANT FROM A DAILY EVERY 

4040
02:44:09,224 --> 02:44:11,560
SINGLE PATIENT.  WE CURRENTLY 

4041
02:44:11,560 --> 02:44:13,595
FINALIZING THE COMMON DATA 

4042
02:44:13,595 --> 02:44:15,531
ELEMENTS.  ALSO THE PATIENT 

4043
02:44:15,531 --> 02:44:16,665
REPORTED OUTCOME MEASURES AND 

4044
02:44:16,665 --> 02:44:18,667
THE PROTOCOL AND HOPE TO BEGIN 

4045
02:44:18,667 --> 02:44:22,104
ENROLLMENT ON THE STUDY IN 2025.

4046
02:44:22,104 --> 02:44:26,375
THE PATIENT HAS TO BE A CHILD OR

4047
02:44:26,375 --> 02:44:27,576
ADOLESCENT AND YOUNG ADULT 

4048
02:44:27,576 --> 02:44:29,144
CURRENTLY DIAGNOSED WITH A RARE 

4049
02:44:29,144 --> 02:44:30,546
SOLID TUMOR.  I ALREADY 

4050
02:44:30,546 --> 02:44:31,813
MENTIONED THESE PATIENTS WILL 

4051
02:44:31,813 --> 02:44:37,019
HAVE ACCESS TO THE

4052
02:44:37,019 --> 02:44:38,554
AND WE HOPE ONCE WE ESTABLISH

4053
02:44:38,554 --> 02:44:40,255
FEASIBILITY THAT WE CAN EXPAND

4054
02:44:40,255 --> 02:44:42,457
THE STUDY TO RARE BLOOD CANCERS

4055
02:44:42,457 --> 02:44:43,358
IN THE FUTURE.

4056
02:44:43,358 --> 02:44:46,395
THANK YOU VERY MUCH FOR

4057
02:44:46,395 --> 02:44:47,563
LISTENING, AND BE HAPPY, THE

4058
02:44:47,563 --> 02:44:49,565
THREE OF US, TO TAKE QUESTIONS.

4059
02:44:49,565 --> 02:44:52,634
>> THANK YOU SO MUCH.

4060
02:44:52,634 --> 02:44:56,438
FANTASTIC PRESENTATION.

4061
02:44:56,438 --> 02:45:04,680
CRITICALLY IMPORTANT AREA. 

4062
02:45:04,680 --> 02:45:05,914
DR. HAYES DIXON?

4063
02:45:05,914 --> 02:45:08,850
>> THANK YOU, TEAM, FOR
THAT

4064
02:45:08,850 --> 02:45:09,952
EXCELLENT PRESENTATION.

4065
02:45:09,952 --> 02:45:11,820
AS PEDIATRIC ONCOLOGIST I WAS

4066
02:45:11,820 --> 02:45:13,121
INVOLVED IN THE FIRST MEETING

4067
02:45:13,121 --> 02:45:15,624
BEFORE I STEPPED DOWN TO BE ON

4068
02:45:15,624 --> 02:45:17,159
THIS COMMITTEE, YOU GUYS HAVE

4069
02:45:17,159 --> 02:45:18,260
DONE A PHENOMENAL JOB WITH WHAT

4070
02:45:18,260 --> 02:45:19,027
YOU HAVE.

4071
02:45:19,027 --> 02:45:21,563
I REMEMBER ALL THE ISSUES THAT

4072
02:45:21,563 --> 02:45:23,298
WE WERE TACKLING, YOU TACKLED

4073
02:45:23,298 --> 02:45:25,467
THEM VERY WELL.

4074
02:45:25,467 --> 02:45:30,539
THE TWO QUESTIONS I HAVE, NOW

4075
02:45:30,539 --> 02:45:31,940
THAT WE MOVED FORWARDOUT SIDE OF

4076
02:45:31,940 --> 02:45:37,980
THE  COG WE SHOULD BE ABLE TO

4077
02:45:37,980 --> 02:45:39,715
FURTHER THE NUMBERS OTHER THAN

4078
02:45:39,715 --> 02:45:40,916
THE ONES YOU REPORTED.

4079
02:45:40,916 --> 02:45:44,419
HOW ARE MOLECULAR

4080
02:45:44,419 --> 02:45:45,854
CHARACTERIZATIONS GOING TO BE

4081
02:45:45,854 --> 02:45:46,521
COMMUNICATED TO INVESTIGATORS TO

4082
02:45:46,521 --> 02:45:48,190
GETTER INFORM THEM ON CLINICAL

4083
02:45:48,190 --> 02:45:49,358
TRIALS OUTSIDE OF THE COG?

4084
02:45:49,358 --> 02:45:52,628
HOW IS THAT GOING TO BE

4085
02:45:52,628 --> 02:45:52,961
COMMUNICATED?

4086
02:45:52,961 --> 02:45:55,364
>> THAT'S AN EXCELLENT
QUESTION.

4087
02:45:55,364 --> 02:45:59,635
AS WE'VE BEEN DISCUSSING,

4088
02:45:59,635 --> 02:46:00,736
ENROLLMENT WILL BE -- WE'LL

4089
02:46:00,736 --> 02:46:02,170
ENSURE A PATIENT ENROLLED NEEDS

4090
02:46:02,170 --> 02:46:03,872
TO HAVE A DOCTOR, ONE KEY

4091
02:46:03,872 --> 02:46:04,573
REQUIREMENT, BECAUSE WE'LL NEED

4092
02:46:04,573 --> 02:46:08,744
TO MAKE SURE THAT WE CAN REPORT

4093
02:46:08,744 --> 02:46:09,478
THE RESULTS BACK.

4094
02:46:09,478 --> 02:46:11,880
FOR PATIENTS WHO HAVE A DOCTOR

4095
02:46:11,880 --> 02:46:13,215
WHO DOESN'T FEEL COMFORTABLE

4096
02:46:13,215 --> 02:46:15,817
DEALING WITH THE MOLECULAR

4097
02:46:15,817 --> 02:46:19,254
RESULTS, WE WILL OFFER THAT WE

4098
02:46:19,254 --> 02:46:21,623
CAN HELP THE PHYSICIAN OF THE

4099
02:46:21,623 --> 02:46:22,524
INDIVIDUAL PATIENT WITH

4100
02:46:22,524 --> 02:46:27,763
COMMUNICATION OF THE MOLECULAR

4101
02:46:27,763 --> 02:46:29,297
RESULTS, ONCOLOGY GROUP

4102
02:46:29,297 --> 02:46:31,466
PARTICIPANTS THAT WILL BE LESS

4103
02:46:31,466 --> 02:46:33,669
OF AN ISSUE BUT WE'LL MAKE SURE

4104
02:46:33,669 --> 02:46:35,303
THE SERVICE CAN BE PROVIDED TO A

4105
02:46:35,303 --> 02:46:37,272
PHYSICIAN IN A MORE RURAL AREA

4106
02:46:37,272 --> 02:46:38,040
AND CANNOT INTERPRET THE

4107
02:46:38,040 --> 02:46:46,014
FINDINGS AS WELL. 

4108
02:46:46,014 --> 02:46:47,783
>> THE OTHER QUESTION IS,
WHEN

4109
02:46:47,783 --> 02:46:51,720
WE STARTED THIS WE THOUGHT $250

4110
02:46:51,720 --> 02:46:53,689
MILLION WAS A LOT OF MONEY BUT

4111
02:46:53,689 --> 02:46:55,123
WHEN WE GOT INTO THE AMOUNT OF

4112
02:46:55,123 --> 02:46:56,425
EFFORT AND TIME TO COLLECT THIS

4113
02:46:56,425 --> 02:46:58,427
DATA, THIS IS A MASSIVE, MASSIVE

4114
02:46:58,427 --> 02:47:00,495
AMOUNT OF DATA THAT HAS TO BE

4115
02:47:00,495 --> 02:47:00,929
COLLECTED.

4116
02:47:00,929 --> 02:47:05,834
I APPRECIATE THAT.

4117
02:47:05,834 --> 02:47:07,469
DO YOU THINK THAT -- NEED THIS

4118
02:47:07,469 --> 02:47:10,305
GROUP TO HEAR IT -- THAT THE

4119
02:47:10,305 --> 02:47:11,440
REMAINING FUNDING IS SUFFICIENT

4120
02:47:11,440 --> 02:47:13,375
TO ACCOMPLISH THE GOALS YOU

4121
02:47:13,375 --> 02:47:13,775
OUTLINED?

4122
02:47:13,775 --> 02:47:14,309
>> THAT'S ANOTHER GREAT

4123
02:47:14,309 --> 02:47:14,576
QUESTION.

4124
02:47:14,576 --> 02:47:18,914
WE HAVE, YOU KNOW, VERY

4125
02:47:18,914 --> 02:47:19,548
DIFFERENT OPINIONS.

4126
02:47:19,548 --> 02:47:21,616
THIS WAS GOING TO BE CO-LED FROM

4127
02:47:21,616 --> 02:47:26,621
THE INTRAMURAL SIDE, WE WOULD

4128
02:47:26,621 --> 02:47:28,824
LOVE TO SEE MANY ENROLLMENTS AND

4129
02:47:28,824 --> 02:47:30,525
HAVE THIS PROBLEM.

4130
02:47:30,525 --> 02:47:31,660
THE CANCER STUDY WILL BE QUITE

4131
02:47:31,660 --> 02:47:36,865
RARE, IF WE WERE ABLE TO, THAT

4132
02:47:36,865 --> 02:47:39,634
MIGHT BE A GOOD PROBLEM TO HAVE.

4133
02:47:39,634 --> 02:47:41,603
OTHERS HAVE SAID YOU'LL BE

4134
02:47:41,603 --> 02:47:42,637
SURPRISED, WE'LL BE ENROLLING

4135
02:47:42,637 --> 02:47:44,039
MORE PATIENTS, AND I THINK IT'S

4136
02:47:44,039 --> 02:47:45,674
SOMETHING WE'LL HAVE TO MONITOR

4137
02:47:45,674 --> 02:47:49,311
VERY CLOSELY BECAUSE, YOU'RE

4138
02:47:49,311 --> 02:47:50,145
RIGHT, THE DATA ABSTRACTION

4139
02:47:50,145 --> 02:47:51,580
WE'RE PLANNING FROM EVERY

4140
02:47:51,580 --> 02:47:52,347
PATIENT DOES TAKE TIME.

4141
02:47:52,347 --> 02:47:56,518
IF WE WERE TO GET EVERY PATIENT

4142
02:47:56,518 --> 02:47:58,386
WITH A RARE TUMOR IT COULD

4143
02:47:58,386 --> 02:48:00,655
BECOME A PROBLEM.

4144
02:48:00,655 --> 02:48:01,022
>> THANK YOU.

4145
02:48:01,022 --> 02:48:06,161
>> YOU SAID BRAIN TUMOR, I
HAD

4146
02:48:06,161 --> 02:48:07,229
TO JUMP IN.

4147
02:48:07,229 --> 02:48:11,099
THANK YOU FOR THE WONDERFUL TALK

4148
02:48:11,099 --> 02:48:13,068
THAT YOU GAVE ON GLIOMA.

4149
02:48:13,068 --> 02:48:15,370
IN THE ADULT WORLD WE'RE NOW

4150
02:48:15,370 --> 02:48:17,773
MOVING MORE AGGRESSIVELY WITH

4151
02:48:17,773 --> 02:48:18,974
TISSUE COLLECTION, AND AFTER

4152
02:48:18,974 --> 02:48:20,942
LOOKING LIKE A CRAZY PERSON

4153
02:48:20,942 --> 02:48:23,011
TALKING IN MEETINGS ABOUT TRYING

4154
02:48:23,011 --> 02:48:25,213
TO GET MULTIPLE BIOPSIES,

4155
02:48:25,213 --> 02:48:28,150
TREATMENT BIOPSIES, BRAIN

4156
02:48:28,150 --> 02:48:29,084
TUMORS, THERE'S NOW MULTIPLE

4157
02:48:29,084 --> 02:48:31,453
PHYSICIAN STATEMENTS IN THE

4158
02:48:31,453 --> 02:48:33,855
ADULT BRAIN TUMOR WORLD SAYING

4159
02:48:33,855 --> 02:48:37,459
THE ONLY WAY TO MAKE PROGRESS IS

4160
02:48:37,459 --> 02:48:38,660
INTERROGATING TISSUE AND

4161
02:48:38,660 --> 02:48:40,095
UNDERSTANDING WHAT'S GOING ON. 

4162
02:48:40,095 --> 02:48:42,597
THE DATA ABOUT CSF NOT

4163
02:48:42,597 --> 02:48:43,165
NECESSARILY REFLECTING TUMOR

4164
02:48:43,165 --> 02:48:44,332
GENOMICS, IN MOST OF THE CASES,

4165
02:48:44,332 --> 02:48:49,805
THOUGH US DID IT  -- IT DOES INA

4166
02:48:49,805 --> 02:48:50,272
FEW.

4167
02:48:50,272 --> 02:48:51,373
THERE ARE HUGE ETHICAL

4168
02:48:51,373 --> 02:48:52,641
CHALLENGES IN CHILDREN WITH THIS

4169
02:48:52,641 --> 02:48:55,076
BUT TO WHERE WE'RE GOING TO BE

4170
02:48:55,076 --> 02:48:57,813
ABLE TO IN SELECT COHORTS, IN

4171
02:48:57,813 --> 02:49:00,415
PARTICULAR, AREAS START LOOKING

4172
02:49:00,415 --> 02:49:01,883
AT ON-TREATMENT BIOPSIES, WINDOW

4173
02:49:01,883 --> 02:49:06,588
OF OPPORTUNITY STUDIES IN THE

4174
02:49:06,588 --> 02:49:08,957
PEDIATRIC WORLD AS WELL?

4175
02:49:08,957 --> 02:49:09,424
>> AWESOME QUESTION.

4176
02:49:09,424 --> 02:49:11,693
SARAH, DO YOU WANT TO

4177
02:49:11,693 --> 02:49:12,694
POTENTIALLY RESPOND?

4178
02:49:12,694 --> 02:49:13,895
>> YEAH, ABSOLUTELY.

4179
02:49:13,895 --> 02:49:15,864
ONE, I DO WANT TO MAKE THE POINT

4180
02:49:15,864 --> 02:49:19,568
FOR THE PREVIOUS QUESTION ALSO

4181
02:49:19,568 --> 02:49:21,236
THE RESULTS ARE RETURNED TO

4182
02:49:21,236 --> 02:49:22,537
TREATING PHYSICIANS, NOT JUST

4183
02:49:22,537 --> 02:49:25,040
FOR THE TEAM BEING USED NOW,

4184
02:49:25,040 --> 02:49:29,544
THEY CAN BE USED FOR ALL OUR

4185
02:49:29,544 --> 02:49:33,481
STUDIES OR CLINICAL PURPOSES.

4186
02:49:33,481 --> 02:49:34,149
SEQUENTIAL INFORMATION, WE

4187
02:49:34,149 --> 02:49:35,784
STRUGGLE WITH THAT AS WELL.

4188
02:49:35,784 --> 02:49:37,953
ONE OF THE THINGS I THINK UP AND

4189
02:49:37,953 --> 02:49:42,023
COMING, THERE HAVE BEEN A FEW

4190
02:49:42,023 --> 02:49:42,991
PHYSICIAN -- AND PAPERS

4191
02:49:42,991 --> 02:49:45,060
PUBLISHED ON THIS, WHAT WE MIGHT

4192
02:49:45,060 --> 02:49:47,262
LEARN BY CSF IN BRAIN TUMORS.

4193
02:49:47,262 --> 02:49:49,464
SO THAT'S SOMETHING THAT'S VERY

4194
02:49:49,464 --> 02:49:51,967
IMPORTANT THAT WE'RE COLLECTING,

4195
02:49:51,967 --> 02:49:54,069
AND NEW TECHNIQUES INCLUDING

4196
02:49:54,069 --> 02:49:57,539
SOME OF THE SEQUENCING WITHIN

4197
02:49:57,539 --> 02:50:03,578
CSF WE DO ACTUALLY PICK UP

4198
02:50:03,578 --> 02:50:05,447
MUTATIONS SEQUENTIALLY AND EVEN

4199
02:50:05,447 --> 02:50:06,748
WITH BIOPSY YOU'RE PUTTING A

4200
02:50:06,748 --> 02:50:09,584
NEEDLE IN A DIFFICULT PLACE,

4201
02:50:09,584 --> 02:50:11,453
NONE OF THESE TUMORS -- ALMOST

4202
02:50:11,453 --> 02:50:13,521
NONE ARE COMPLETELY RECEPTIVE SO

4203
02:50:13,521 --> 02:50:14,522
WE'RE MISSING TUMOR BIOPSIES AND

4204
02:50:14,522 --> 02:50:18,460
HAVE FOUND IN SOME CASES WE CAN

4205
02:50:18,460 --> 02:50:19,661
DETECT MUTATIONS EVEN WITHOUT

4206
02:50:19,661 --> 02:50:24,866
CYTOLOGY POSITIVE IN THE CSF,

4207
02:50:24,866 --> 02:50:27,435
AND I HOPE MAKING AN INVESTMENT

4208
02:50:27,435 --> 02:50:28,536
IN THAT TECHNOLOGY, THINKING

4209
02:50:28,536 --> 02:50:31,573
ABOUT HOW TO DO THAT, LIKE WITH

4210
02:50:31,573 --> 02:50:33,475
NCI, WHERE IT CAN REACH ALL THE

4211
02:50:33,475 --> 02:50:34,743
POTENTIAL PATIENTS WHO MIGHT

4212
02:50:34,743 --> 02:50:36,077
NEED THAT KIND OF TESTING OR BE

4213
02:50:36,077 --> 02:50:37,512
ABLE TO USE IT.

4214
02:50:37,512 --> 02:50:39,481
>> YEAH, IT WOULD BE
FANTASTIC

4215
02:50:39,481 --> 02:50:43,618
ALSO TO BEGIN TO THINK ABOUT

4216
02:50:43,618 --> 02:50:44,653
COLLECTING LIVING -- LIVE

4217
02:50:44,653 --> 02:50:45,987
TISSUE, WHEN AND WHERE YOU CAN

4218
02:50:45,987 --> 02:50:48,723
TO BUILD SORT OF A LIVING

4219
02:50:48,723 --> 02:50:49,891
BIOREPOSITORY TO STUDY THE

4220
02:50:49,891 --> 02:50:50,592
BIOLOGY OF THESE CANCERS.

4221
02:50:50,592 --> 02:50:52,994
I THINK THAT WOULD BE A GREAT

4222
02:50:52,994 --> 02:50:54,629
OPPORTUNITY AS WELL AS EXTENDING

4223
02:50:54,629 --> 02:50:59,434
TO SOME OF THE ADVANCED

4224
02:50:59,434 --> 02:51:09,945
TECHNOLOGY SINGLE CELL SPATIAL

4225
02:51:10,779 --> 02:51:12,247
FOR THE DATA.

4226
02:51:12,247 --> 02:51:13,448
BY RACE AND ETHNICITY, YOU KNOW,

4227
02:51:13,448 --> 02:51:16,484
DO YOU SEE DIFFERENCES IN STAGE

4228
02:51:16,484 --> 02:51:17,452
OF DIAGNOSIS.

4229
02:51:17,452 --> 02:51:19,220
IF YOU STRATIFY BY RACE AND

4230
02:51:19,220 --> 02:51:21,556
ETHNICITY OR OUTCOMES.

4231
02:51:21,556 --> 02:51:24,759
ALSO, YOU HAVE WHOLE EXOME

4232
02:51:24,759 --> 02:51:27,028
EXPENSING DATA ON ALMOST 2,000,

4233
02:51:27,028 --> 02:51:32,834
THINKING ABOUT GENETIC

4234
02:51:32,834 --> 02:51:33,601
SIMILARITY OR ANCESTRY ANALYSIS,

4235
02:51:33,601 --> 02:51:36,438
ARE YOU THINKING ABOUT THAT?

4236
02:51:36,438 --> 02:51:37,138
>> GREAT COMMENT.

4237
02:51:37,138 --> 02:51:39,174
SARAH, DO YOU WANT TO RESPOND?

4238
02:51:39,174 --> 02:51:41,042
OR DIANA, THE COHORT, LARGEST

4239
02:51:41,042 --> 02:51:42,143
FROM THE NCI?

4240
02:51:42,143 --> 02:51:44,779
>> OUR COHORT THAT WE'RE
PUTTING

4241
02:51:44,779 --> 02:51:47,949
TOGETHER TO BE A RESOURCE FOR

4242
02:51:47,949 --> 02:51:51,553
OTHERS IN THE COMMUNITY.

4243
02:51:51,553 --> 02:51:52,787
YEAH, SO CANCER PREDISPOSITION

4244
02:51:52,787 --> 02:51:55,724
PROJECT IS GOING TO LOOK MORE AT

4245
02:51:55,724 --> 02:51:56,891
THE CONSTITUTIONAL GENOMICS FOR

4246
02:51:56,891 --> 02:51:57,092
SURE.

4247
02:51:57,092 --> 02:51:58,426
THAT'S NOT MY PERSONAL AREA OF

4248
02:51:58,426 --> 02:52:03,498
RESEARCH BUT IT'S A PROJECT ALSO

4249
02:52:03,498 --> 02:52:04,699
WITH THIS DATA.

4250
02:52:04,699 --> 02:52:06,334
I THINK ALMOST THE SKY'S THE

4251
02:52:06,334 --> 02:52:07,769
LIMIT IF WE CAN PUT IT TOGETHER

4252
02:52:07,769 --> 02:52:10,605
FOR ALL TYPES OF RESEARCHERS,

4253
02:52:10,605 --> 02:52:12,474
BUT SOME OF THE WORK I DO AT MY

4254
02:52:12,474 --> 02:52:14,275
OWN INSTITUTION IN TERMS OF

4255
02:52:14,275 --> 02:52:15,543
TRIAL ENROLLMENT, TRYING TO BE

4256
02:52:15,543 --> 02:52:19,481
INCLUSIVE, THIS IS AN EXAMPLE OF

4257
02:52:19,481 --> 02:52:20,982
BEING AS INCLUSIVE AS ANYTHING

4258
02:52:20,982 --> 02:52:22,851
I'VE EVER SEEN IN TERMS OF

4259
02:52:22,851 --> 02:52:24,052
DEMOGRAPHICS REPRESENTED HERE,

4260
02:52:24,052 --> 02:52:27,255
BOTH RURAL AS WELL AS RACIAL.

4261
02:52:27,255 --> 02:52:28,656
AND ETHNIC IDENTITIES.

4262
02:52:28,656 --> 02:52:32,160
AND I THINK PART OF IT IS IS THE

4263
02:52:32,160 --> 02:52:33,461
ACCESSIBILITY THE CHILDREN THAT

4264
02:52:33,461 --> 02:52:34,329
TRAVEL FOR TREATMENT DON'T NEED

4265
02:52:34,329 --> 02:52:36,431
TO TRAVEL FOR THIS KIND OF

4266
02:52:36,431 --> 02:52:37,098
TESTING NECESSARILY.

4267
02:52:37,098 --> 02:52:39,834
YOU KNOW, THE TESTING CAN BE

4268
02:52:39,834 --> 02:52:41,136
CENTRAL, BUT THE CHILD CAN STAY

4269
02:52:41,136 --> 02:52:42,771
AT THEIR INSTITUTION.

4270
02:52:42,771 --> 02:52:46,074
I THINK WE NEED MORE OF THAT.

4271
02:52:46,074 --> 02:52:48,243
I THINK I'M GOING OFF ON A

4272
02:52:48,243 --> 02:52:51,079
TANGENT BUT COULD THIS BE USED,

4273
02:52:51,079 --> 02:52:51,379
ABSOLUTELY.

4274
02:52:51,379 --> 02:52:52,414
THIS IS GROWING RAPIDLY, EVEN

4275
02:52:52,414 --> 02:52:54,549
MORE RAPIDLY THAN THE FIRST 20

4276
02:52:54,549 --> 02:52:58,186
MONTHS, WE'RE OVER 3,000 CASES

4277
02:52:58,186 --> 02:52:58,520
NOW.

4278
02:52:58,520 --> 02:53:00,588
MOST RECENT SIX MONTHS OF DATA

4279
02:53:00,588 --> 02:53:03,224
ARE BEING SUBMIT AND UPLOADED

4280
02:53:03,224 --> 02:53:04,659
NOW FOR AVAILABILITY.

4281
02:53:04,659 --> 02:53:06,961
GENOMICS GO IN EVERY MONTH, AND

4282
02:53:06,961 --> 02:53:08,596
CLINICAL DATA FROM THE REGISTRY

4283
02:53:08,596 --> 02:53:10,932
GO IN EVERY SIX MONTHS.

4284
02:53:10,932 --> 02:53:14,269
AND I THINK THIS IS UNIQUE IN MY

4285
02:53:14,269 --> 02:53:16,271
CAREER, AN OPPORTUNITY TO LOOK

4286
02:53:16,271 --> 02:53:18,006
AT THIS NUMBER OF PATIENTS WITH

4287
02:53:18,006 --> 02:53:19,874
DATA COLLECTED UNIFORMLY.

4288
02:53:19,874 --> 02:53:20,975
>> I TOTALLY AGREE.

4289
02:53:20,975 --> 02:53:22,243
KIM, IN TERMS OF THINGS WE CAN

4290
02:53:22,243 --> 02:53:23,812
DO AND IN TERMS OF

4291
02:53:23,812 --> 02:53:25,146
COMMUNICATION, YOU KNOW, ACCESS

4292
02:53:25,146 --> 02:53:28,316
TO THESE TYPES OF RESOURCES

4293
02:53:28,316 --> 02:53:31,486
ACROSS, YOU KNOW, VARIOUS

4294
02:53:31,486 --> 02:53:33,354
ACADEMIC ORGANIZATIONS.

4295
02:53:33,354 --> 02:53:33,755
JULIE?

4296
02:53:33,755 --> 02:53:38,393
>> IT'S A GREAT PIGGYBACK
TO

4297
02:53:38,393 --> 02:53:39,727
WHAT I WAS THINKING.

4298
02:53:39,727 --> 02:53:41,629
WHAT YOU'RE DOING IS AMAZING.

4299
02:53:41,629 --> 02:53:42,630
IT REALLY MATTERS TO THESE

4300
02:53:42,630 --> 02:53:43,364
FAMILIES AND PATIENTS.

4301
02:53:43,364 --> 02:53:47,035
I WANT TO SAY THANK YOU FOR YOUR

4302
02:53:47,035 --> 02:53:47,702
WORK.

4303
02:53:47,702 --> 02:53:49,237
SLIDE 14 THAT YOU PRESENTED, THE

4304
02:53:49,237 --> 02:53:51,106
HEAT MAP FOR THE UNITED STATES,

4305
02:53:51,106 --> 02:53:52,640
THE NUMBER OF SUBJECTS BY ZIP

4306
02:53:52,640 --> 02:53:56,211
CODE, WHAT REALLY STRUCK ME IS

4307
02:53:56,211 --> 02:53:57,445
THAT BOSTON, SAN FRANCISCO, AND

4308
02:53:57,445 --> 02:53:59,414
SOME MAJOR METROS ARE NOT THE

4309
02:53:59,414 --> 02:54:00,949
LARGEST SOURCES OF PATIENT

4310
02:54:00,949 --> 02:54:01,216
SAMPLES.

4311
02:54:01,216 --> 02:54:02,150
PERHAPS YOU COULD HELP ME

4312
02:54:02,150 --> 02:54:03,351
UNDERSTAND IF YOU THINK THE

4313
02:54:03,351 --> 02:54:05,620
REASON FOR THE CENTERS OF

4314
02:54:05,620 --> 02:54:06,754
EXCELLENCE, OFTEN THOSE

4315
02:54:06,754 --> 02:54:07,856
PEDIATRIC PATIENTS ARE TREATED,

4316
02:54:07,856 --> 02:54:09,691
IS BECAUSE THE STATE IS JUST

4317
02:54:09,691 --> 02:54:10,692
WHERE THEY LIVE?

4318
02:54:10,692 --> 02:54:12,460
AND THE SECOND, ARE THESE PANELS

4319
02:54:12,460 --> 02:54:16,798
ACTUALLY A SUPPLEMENT TO THE

4320
02:54:16,798 --> 02:54:18,433
INSTITUTIONS THAT DO NOT DO

4321
02:54:18,433 --> 02:54:19,868
GENOMIC TESTING ON THEIR OWN.

4322
02:54:19,868 --> 02:54:21,302
INSTITUTIONS DO THIS IN HOUSE,

4323
02:54:21,302 --> 02:54:23,905
PROBABLY NOT IN ANY DATASET.

4324
02:54:23,905 --> 02:54:25,974
HOW DO YOU HARMONIZE THAT?

4325
02:54:25,974 --> 02:54:27,675
WHY I'M INTERESTED, AS A PERSON

4326
02:54:27,675 --> 02:54:28,843
FROM INDUSTRY, WE'RE TRYING TO

4327
02:54:28,843 --> 02:54:30,812
INCREASE THE NUMBER OF TRIALS WE

4328
02:54:30,812 --> 02:54:32,280
PURSUE FOR CHILDREN WITH CANCER.

4329
02:54:32,280 --> 02:54:34,983
SOME OF IT FROM OBLIGATIONS,

4330
02:54:34,983 --> 02:54:40,288
FROM BOTH FDA AND EUROPEAN

4331
02:54:40,288 --> 02:54:44,058
REGULATORS FROM PIPS AND PDARA.

4332
02:54:44,058 --> 02:54:46,461
WE LOOK AT CGA, PROTOCOLS, WHICH

4333
02:54:46,461 --> 02:54:47,462
PATIENT POPULATIONS WE SHOULD

4334
02:54:47,462 --> 02:54:48,096
PRIORITIZE FOR THOSE

4335
02:54:48,096 --> 02:54:50,064
APPLICATIONS IN THE STUDIES.

4336
02:54:50,064 --> 02:54:51,332
I'M CURIOUS, THE FINAL QUESTION,

4337
02:54:51,332 --> 02:54:54,569
IF THIS DATA WILL BE INTEGRATED

4338
02:54:54,569 --> 02:54:55,436
INTO TCGA WHICH INDUSTRY LEANS

4339
02:54:55,436 --> 02:54:59,707
ON AS THE SOURCE OF THINKING

4340
02:54:59,707 --> 02:55:05,480
ABOUT EPIDEMIOLOGY AND

4341
02:55:05,480 --> 02:55:06,281
UNDERLYING GENOMICS TO ENROLL?

4342
02:55:06,281 --> 02:55:07,782
>> SARAH, DO YOU WANT TO
COMMENT

4343
02:55:07,782 --> 02:55:09,751
ON THE POTENTIAL SOURCE OF

4344
02:55:09,751 --> 02:55:11,853
SAMPLES AND WHO PARTICIPATES IN

4345
02:55:11,853 --> 02:55:15,557
THE MCI AND WHO DOESN'T?

4346
02:55:15,557 --> 02:55:17,492
>> YEAH, WHAT WE'RE
SEEING, DR.

4347
02:55:17,492 --> 02:55:20,595
THOMAS, WHAT THIS IS HELPING

4348
02:55:20,595 --> 02:55:21,996
LIKE YOU'VE SEEN THE SITES WITH

4349
02:55:21,996 --> 02:55:27,602
THEIR OWN TESTING, FROM A LARGE

4350
02:55:27,602 --> 02:55:29,237
SITE OURSELVES, WE'RE HIGH

4351
02:55:29,237 --> 02:55:31,206
ENROLLING, OUR PHILOSOPHY DOING

4352
02:55:31,206 --> 02:55:32,674
OUR OWN TESTING, CLINICAL

4353
02:55:32,674 --> 02:55:34,075
RESEARCH, OURS ARE LIKE THAT.

4354
02:55:34,075 --> 02:55:36,911
OTHER SITES HAVE WHAT THEY NEED

4355
02:55:36,911 --> 02:55:38,580
FOR CLINICAL DIAGNOSIS OR DOING

4356
02:55:38,580 --> 02:55:40,448
THEIR OWN IN-HOUSE RESEARCH AND

4357
02:55:40,448 --> 02:55:42,850
PRIORITIZE THAT OVER

4358
02:55:42,850 --> 02:55:43,818
PARTICIPATION IN THE MCI.

4359
02:55:43,818 --> 02:55:46,120
I THINK WE TRIED TO SET IT UP TO

4360
02:55:46,120 --> 02:55:47,222
BE REASONABLE FOR SITES LIKE

4361
02:55:47,222 --> 02:55:55,430
THAT TO DO BOTH, WHICH IS GREAT.

4362
02:55:55,430 --> 02:55:59,234
THE MORE WE DO, THE MORE

4363
02:55:59,234 --> 02:56:04,105
RELEARN. -- WE LEARN. 

4364
02:56:04,105 --> 02:56:06,274
IN TERMS OF INTEGRATING, TUMORS

4365
02:56:06,274 --> 02:56:08,476
THAT WEREN'T INCLUDED IN TCGA,

4366
02:56:08,476 --> 02:56:10,578
MY HOPE IS FOR PEDIATRICS THESE

4367
02:56:10,578 --> 02:56:11,646
PLATFORMS BECOME THE DATA SOURCE

4368
02:56:11,646 --> 02:56:13,314
WHERE EVERYBODY WOULD LIKE.

4369
02:56:13,314 --> 02:56:17,218
CRE PRESENTED THE CNS DATA, MY

4370
02:56:17,218 --> 02:56:22,056
OWN FOCUS IN DATA, THIS IS FOR

4371
02:56:22,056 --> 02:56:23,324
ALL.

4372
02:56:23,324 --> 02:56:24,559
GROWING IN TERMS OF BEING MORE

4373
02:56:24,559 --> 02:56:26,427
INCLUSIVE FOR LOTS AND LOTS OF

4374
02:56:26,427 --> 02:56:28,396
PEDIATRIC TUMORS.

4375
02:56:28,396 --> 02:56:29,230
SOME FROM INTRAMURAL --

4376
02:56:29,230 --> 02:56:31,933
>> SO WE HAVE TWO MORE

4377
02:56:31,933 --> 02:56:33,434
QUESTIONS, AND THEY ARE GOING TO

4378
02:56:33,434 --> 02:56:34,502
EAT INTO OUR LUNCH HOUR.

4379
02:56:34,502 --> 02:56:35,937
BUT THEY ARE FROM TWO

4380
02:56:35,937 --> 02:56:36,971
INDIVIDUALS RETIRING FROM THE

4381
02:56:36,971 --> 02:56:39,674
BOARD SO I WANT TO OBLIGE THEM.

4382
02:56:39,674 --> 02:56:42,844
WE'RE GOING TO START WITH SUSAN

4383
02:56:42,844 --> 02:56:44,579
AND GO TO ANN.

4384
02:56:44,579 --> 02:56:45,813
>> GREAT PRESENTATION,
MAYBE MY

4385
02:56:45,813 --> 02:56:47,115
QUESTION IS EASY.

4386
02:56:47,115 --> 02:56:49,550
I NOTICED THERE WAS A SMALL

4387
02:56:49,550 --> 02:56:52,520
SUBSET OF FOLKS THAT HAD

4388
02:56:52,520 --> 02:56:53,021
GERMLINE INHERITED

4389
02:56:53,021 --> 02:56:55,990
PREDISPOSITION, SO I WAS

4390
02:56:55,990 --> 02:56:57,959
WONDERING HOW DOES THE GENETIC

4391
02:56:57,959 --> 02:56:59,394
COUNSELING ASPECT OF THAT WORK,

4392
02:56:59,394 --> 02:57:02,797
AND WHAT ARE THE OPPORTUNITIES

4393
02:57:02,797 --> 02:57:05,867
FOR CASCADE TESTING WITH

4394
02:57:05,867 --> 02:57:08,936
FAMILIES THAT MAY NOT OTHERWISE

4395
02:57:08,936 --> 02:57:09,704
HAVE ACCESS?

4396
02:57:09,704 --> 02:57:13,975
>> I BELIEVE FOR THE
CHILDREN'S

4397
02:57:13,975 --> 02:57:14,742
ONCOLOGY GROUP PARTICIPANTS,

4398
02:57:14,742 --> 02:57:17,145
IT'S NOT THAT MUCH OF AN ISSUE

4399
02:57:17,145 --> 02:57:19,314
BUT WOULD LIKE SARAH OR DIANA TO

4400
02:57:19,314 --> 02:57:20,281
COMMENT.

4401
02:57:20,281 --> 02:57:21,949
I BELIEVE FOR YOUR PARTICIPANTS,

4402
02:57:21,949 --> 02:57:25,453
MOST OF THE SITES WOULD HAVE

4403
02:57:25,453 --> 02:57:27,422
ACCESS TO GENETIC COUNSELING; IS

4404
02:57:27,422 --> 02:57:27,755
THAT CORRECT?

4405
02:57:27,755 --> 02:57:37,365
>> YEAH, AND WE ACTUALLY
SET UP,

4406
02:57:37,365 --> 02:57:38,366
THE AVAILABILITY THE SITES WOULD

4407
02:57:38,366 --> 02:57:43,171
HAVE, MOST OF US ARE FROM LARGER

4408
02:57:43,171 --> 02:57:44,272
INSTITUTION US BUT WAS SURPRISED

4409
02:57:44,272 --> 02:57:47,542
BY THE QUESTIONS WE'RE GETTING,

4410
02:57:47,542 --> 02:57:48,643
EXTREMELY HIGH LEVEL COMPLEX

4411
02:57:48,643 --> 02:57:49,844
QUESTIONS PERHAPS NONE OF US

4412
02:57:49,844 --> 02:57:51,813
KNOW THE ANSWER TO, AND NOT WHAT

4413
02:57:51,813 --> 02:57:53,915
DO I DO WITH THESE RESULTS,

4414
02:57:53,915 --> 02:57:56,851
SITES ARE ALREADY SEEKING OUT

4415
02:57:56,851 --> 02:58:00,254
THESE KINDS OF RESOURCES AND SO

4416
02:58:00,254 --> 02:58:02,390
MY IMPRESSION IS THAT THE

4417
02:58:02,390 --> 02:58:03,758
PEDIATRIC ONCOLOGISTS, YOU KNOW,

4418
02:58:03,758 --> 02:58:05,593
PRACTICING IN RURAL SITES

4419
02:58:05,593 --> 02:58:10,865
ALREADY HAVE BUILT A NETWORK,

4420
02:58:10,865 --> 02:58:12,500
SOME THROUGH TCOG, POTENTIALLY

4421
02:58:12,500 --> 02:58:15,903
OTHER RESOURCES TO REACH OUT.

4422
02:58:15,903 --> 02:58:18,339
THEY DIDN'T HAVE RAPID

4423
02:58:18,339 --> 02:58:20,375
TURNAROUND OF TESTING UNTIL THE

4424
02:58:20,375 --> 02:58:20,541
MCI.

4425
02:58:20,541 --> 02:58:22,043
QUESTIONS ARE MORE CUTTING EDGE

4426
02:58:22,043 --> 02:58:23,378
QUESTIONS, NOT THE BASIC WHAT DO

4427
02:58:23,378 --> 02:58:24,245
I NEED.

4428
02:58:24,245 --> 02:58:26,748
REMEMBER RESULTS ARE GOING BACK

4429
02:58:26,748 --> 02:58:32,253
TO CLINICIANS, SO THEY HAVE THAT

4430
02:58:32,253 --> 02:58:32,887
DOCTOR/PATIENT RELATIONSHIP,

4431
02:58:32,887 --> 02:58:35,390
FEWER QUESTIONS ABOUT WHAT THE

4432
02:58:35,390 --> 02:58:35,823
RESULTS MEAN.

4433
02:58:35,823 --> 02:58:37,358
>> YEAH, THERE COULD BE AN

4434
02:58:37,358 --> 02:58:39,894
OPPORTUNITY TO ENGAGE WITH THE

4435
02:58:39,894 --> 02:58:41,963
PATIENT ENGAGEMENT AND CANCER

4436
02:58:41,963 --> 02:58:43,164
GENOME SEQUENCING INITIATIVE,

4437
02:58:43,164 --> 02:58:44,165
MOONSHOT INITIATIVE, BECAUSE I

4438
02:58:44,165 --> 02:58:45,900
KNOW THAT GROUP IS ALSO TACKLING

4439
02:58:45,900 --> 02:58:47,668
SOME OF THESE ASPECTS OF RETURN

4440
02:58:47,668 --> 02:58:49,637
OF RESULTS AND CASCADE TESTING.

4441
02:58:49,637 --> 02:58:51,906
ANN, YOU'RE STANDING BETWEEN US

4442
02:58:51,906 --> 02:58:53,040
AND LUNCH.

4443
02:58:53,040 --> 02:58:54,876
>> OH MY GOD, OKAY, VERY

4444
02:58:54,876 --> 02:58:55,209
QUICKLY.

4445
02:58:55,209 --> 02:58:58,946
FIRST OF ALL, CONGRATULATIONS ON

4446
02:58:58,946 --> 02:59:00,014
FINALLY DEMOCRATIZING PEDIATRIC

4447
02:59:00,014 --> 02:59:00,248
DATA.

4448
02:59:00,248 --> 02:59:02,183
IT'S TAKEN US A LONG TIME TO GET

4449
02:59:02,183 --> 02:59:02,383
HERE.

4450
02:59:02,383 --> 02:59:04,519
I THANK YOU SO MUCH FOR THAT.

4451
02:59:04,519 --> 02:59:05,953
THE SECOND THING IN TERMS OF

4452
02:59:05,953 --> 02:59:10,091
RETURN OF RESULTS FOR THAT 12%

4453
02:59:10,091 --> 02:59:11,426
WHERE YOU'RE SEEING GERMLINE

4454
02:59:11,426 --> 02:59:15,897
MUTATIONS IS THAT BEING DONE

4455
02:59:15,897 --> 02:59:17,732
REGULARLY?

4456
02:59:17,732 --> 02:59:19,400
>> YES.

4457
02:59:19,400 --> 02:59:26,174
>> RETURN OF RESULTS, YES?

4458
02:59:26,174 --> 02:59:28,910
THAT'S INTERESTING.

4459
02:59:28,910 --> 02:59:29,477
.

4460
02:59:29,477 --> 02:59:30,745
YOU'RE USING GENETIC COUNSELORS.

4461
02:59:30,745 --> 02:59:32,146
>> IT GOES TO THE TREATING

4462
02:59:32,146 --> 02:59:32,413
PHYSICIAN.

4463
02:59:32,413 --> 02:59:36,250
>> THIS IS A TUMOR WHERE
PEOPLE,

4464
02:59:36,250 --> 02:59:40,188
YOUNG ADULTS AND YOUNG PEOPLE

4465
02:59:40,188 --> 02:59:41,923
LIVE, 72% OR SO SURVIVAL RATE.

4466
02:59:41,923 --> 02:59:45,226
WE SET UP A TRIAL A FEW YEARS

4467
02:59:45,226 --> 02:59:48,729
AGO, CDM AGILE, A PLATFORM

4468
02:59:48,729 --> 02:59:49,697
ADAPTIVE TRIAL.

4469
02:59:49,697 --> 02:59:51,799
IT'S DOING VERY WELL.

4470
02:59:51,799 --> 02:59:58,840
I'M WONDERING IF THIS MIGHT NOT

4471
02:59:58,840 --> 03:00:00,441
BE AN APPROPRIATE APPROACH [

4472
03:00:00,441 --> 03:00:01,242
AUDIO DISTORTION ] PARTICULAR

4473
03:00:01,242 --> 03:00:03,344
TIME. 

4474
03:00:03,344 --> 03:00:04,612
IT MAY BE WORTH LOOKING AT.

4475
03:00:04,612 --> 03:00:05,179
>> THANK YOU.

4476
03:00:05,179 --> 03:00:09,016
I WANT TO MENTION WE'RE VERY

4477
03:00:09,016 --> 03:00:13,521
INTERESTED IN THE CCDI TO FOLLOW

4478
03:00:13,521 --> 03:00:14,722
THESE PATIENTS, WE'RE WORKING

4479
03:00:14,722 --> 03:00:15,456
TOWARDS HAVING SPECIFIC COHORTS

4480
03:00:15,456 --> 03:00:16,891
FOR THESE PATIENTS.

4481
03:00:16,891 --> 03:00:19,527
I WANT TO BRIEFLY MENTION OUR

4482
03:00:19,527 --> 03:00:22,797
WORK IN ESTABLISHING NATIONAL OR

4483
03:00:22,797 --> 03:00:24,565
INTERNATIONAL TUMOR BOARDS FOR

4484
03:00:24,565 --> 03:00:25,766
CLINICAL AND MOLECULAR TUMOR

4485
03:00:25,766 --> 03:00:29,270
BOARDS FOR PATIENTS WHO MAY NOT

4486
03:00:29,270 --> 03:00:30,805
HAVE ACCESS TO SOMEBODY WHO

4487
03:00:30,805 --> 03:00:32,440
FEELS COMFORTABLE MAKING

4488
03:00:32,440 --> 03:00:34,208
TREATMENT DECISIONS AND

4489
03:00:34,208 --> 03:00:35,309
RECOMMENDATIONS, SO THAT'S

4490
03:00:35,309 --> 03:00:36,611
ANOTHER COMPLEMENTARY PART TO

4491
03:00:36,611 --> 03:00:38,679
THE RARE TUMORS INITIATIVE THAT

4492
03:00:38,679 --> 03:00:39,447
I JUST DESCRIBED.

4493
03:00:39,447 --> 03:00:41,315
WE UNDERSTAND THERE ARE MANY

4494
03:00:41,315 --> 03:00:42,416
EFFORTS ONGOING, REACHING OUT TO

4495
03:00:42,416 --> 03:00:47,121
MANY OF THE TEAMS THAT ARE CON

4496
03:00:47,121 --> 03:00:47,989
CONDUCTING THESE TUMOR BOARDS.

4497
03:00:47,989 --> 03:00:50,858
>> THANK YOU FOR THE
FANTASTIC

4498
03:00:50,858 --> 03:00:52,159
PRESENTATION, HIGHLY IMPACTFUL.

4499
03:00:52,159 --> 03:00:56,063
WE'RE NOW GOING TO BREAK FOR

4500
03:00:56,063 --> 03:01:12,174
LUNCH.

4501
03:01:12,174 --> 03:01:15,877
WITH THE CCR ARTIFICIAL

4502
03:01:15,877 --> 03:01:18,013
INTELLIGENCE RESOURCE

4503
03:01:18,013 --> 03:01:20,182
OR AIR, SO YOU'LL GET A CHANCE

4504
03:01:20,182 --> 03:01:23,785
TO SEE HOW WE'RE COORDINATING

4505
03:01:23,785 --> 03:01:25,787
A.I. ACTIVITIES ACROSS NCI AS

4506
03:01:25,787 --> 03:01:28,290
WELL AS SPECIFIC ACTIVITIES CCR

4507
03:01:28,290 --> 03:01:31,226
IS DOING.

4508
03:01:31,226 --> 03:01:32,661
EXCUSE ME.

4509
03:01:32,661 --> 03:01:35,297
SO, YOU CAN SEE VISUALLY, THERE

4510
03:01:35,297 --> 03:01:38,033
WE ALL ARE.

4511
03:01:38,033 --> 03:01:42,070
AND YOU ALREADY HEARD FROM JOHN,

4512
03:01:42,070 --> 03:01:45,574
OUR BRIEF BIOS, I WANTED TO TALK

4513
03:01:45,574 --> 03:01:46,875
BRIEFLY ABOUT MY ROLE SINCE THIS

4514
03:01:46,875 --> 03:01:48,977
IS THE FIRST TIME SINCE I WAS

4515
03:01:48,977 --> 03:01:51,046
APPOINTED THAT I'VE HAD A CHANCE

4516
03:01:51,046 --> 03:01:53,482
TO TALK WITH THE NCAB.

4517
03:01:53,482 --> 03:01:58,186
I AM, AS KIM MENTIONED, THE

4518
03:01:58,186 --> 03:02:01,556
FIRST DEPUTY DIRECTOR FOR DATA

4519
03:02:01,556 --> 03:02:02,324
SCIENCE AND STRATEGY, STARTED AT

4520
03:02:02,324 --> 03:02:03,658
THE END OF JUNE.

4521
03:02:03,658 --> 03:02:06,595
AND PART OF MY ROLE IS REALLY TO

4522
03:02:06,595 --> 03:02:10,298
ADVISE NCI IN ALL THINGS DATA

4523
03:02:10,298 --> 03:02:11,299
SCIENCE AND UNDERSTAND

4524
03:02:11,299 --> 03:02:14,269
STEWARDSHIP, HOW WE THINK ABOUT

4525
03:02:14,269 --> 03:02:16,404
GOOD DATA SHARING PRACTICES,

4526
03:02:16,404 --> 03:02:18,540
PROVIDE SOME STRATEGIC DIRECTION

4527
03:02:18,540 --> 03:02:20,308
TO CBIIT, I FEEL PARTICULARLY

4528
03:02:20,308 --> 03:02:22,377
HONORED TO MOVE FROM BEING CBIIT

4529
03:02:22,377 --> 03:02:25,680
DIRECTOR A NUMBER OF YEARS AGO

4530
03:02:25,680 --> 03:02:27,983
TO NOW BEING AGE TO HELP PROVIDE

4531
03:02:27,983 --> 03:02:30,318
A LITTLE MORE STRATEGIC

4532
03:02:30,318 --> 03:02:31,386
DIRECTION FOR CBIIT.

4533
03:02:31,386 --> 03:02:35,323
THINK ABOUT HOW WE'RE GOING TO

4534
03:02:35,323 --> 03:02:38,927
INTEGRATE THE NIH PLANS AROUND

4535
03:02:38,927 --> 03:02:40,662
DATA SCIENCE INTO NCI.

4536
03:02:40,662 --> 03:02:41,763
SOMETHING THAT IS REALLY

4537
03:02:41,763 --> 03:02:44,599
IMPORTANT AS WE DO THAT, ALSO

4538
03:02:44,599 --> 03:02:46,134
INFORMING WHAT HHS PLANS TO DO

4539
03:02:46,134 --> 03:02:48,503
WITH DATA SCIENCE, WHAT HHS IS

4540
03:02:48,503 --> 03:02:54,242
PLANNING TO DO WITH A.I. 

4541
03:02:54,242 --> 03:02:55,644
AND THEN PROVIDE COUNSEL ACROSS

4542
03:02:55,644 --> 03:02:58,280
NCI AND NIH AROUND SPECIFIC

4543
03:02:58,280 --> 03:02:58,580
ACTIVITIES.

4544
03:02:58,580 --> 03:03:00,649
THAT'S A LITTLE BIT ABOUT WHAT

4545
03:03:00,649 --> 03:03:02,684
I'M DOING.

4546
03:03:02,684 --> 03:03:05,420
A LITTLE BIT ABOUT MYSELF, AS I

4547
03:03:05,420 --> 03:03:08,023
JUST MENTIONED, I WAS THE CBIIT

4548
03:03:08,023 --> 03:03:11,226
DIRECTOR BACK IN 2013 UNTIL

4549
03:03:11,226 --> 03:03:11,426
2017.

4550
03:03:11,426 --> 03:03:15,931
THE LAST YEAR OF THAT TIME I WAS

4551
03:03:15,931 --> 03:03:18,300
ALSO PRIVILEGED TO BE ONE OF THE

4552
03:03:18,300 --> 03:03:22,070
ACTING DIRECTORS, PART OF THE

4553
03:03:22,070 --> 03:03:25,340
CANCER MOONSHOT WAS DOUG WAS

4554
03:03:25,340 --> 03:03:27,209
ACTING NCI DIRECTOR.

4555
03:03:27,209 --> 03:03:30,278
I LEFT NCI IN 2017 TO MOVE TO

4556
03:03:30,278 --> 03:03:32,147
DUKE, WHERE I WAS THE VICE CHAIR

4557
03:03:32,147 --> 03:03:34,983
FOR THE DEPARTMENT OF

4558
03:03:34,983 --> 03:03:35,550
BIOSTATISTICS AND

4559
03:03:35,550 --> 03:03:36,618
BIOINFORMATICS, ALSO THE CHIEF

4560
03:03:36,618 --> 03:03:38,587
DATA OFFICER FOR THE DUKE CANCER

4561
03:03:38,587 --> 03:03:39,421
INSTITUTE.

4562
03:03:39,421 --> 03:03:41,456
AND THEN AS YOU HEARD CAME BACK

4563
03:03:41,456 --> 03:03:44,859
HERE TO NCI ON JUNE 30, I'M VERY

4564
03:03:44,859 --> 03:03:50,765
EXCITED TO BE BACK.

4565
03:03:50,765 --> 03:03:51,967
SO THIS PRESENTATION IS ALL

4566
03:03:51,967 --> 03:03:52,601
ABOUT A.I.

4567
03:03:52,601 --> 03:03:54,469
I THOUGHT IT WOULD BE GOOD TO

4568
03:03:54,469 --> 03:03:55,904
GIVE YOU BACKGROUND WHERE A.I.

4569
03:03:55,904 --> 03:03:57,872
COMES FROM, WHERE AT LEAST FROM

4570
03:03:57,872 --> 03:03:59,274
MY PERSPECTIVE WHERE WE'RE

4571
03:03:59,274 --> 03:03:59,608
HEADED.

4572
03:03:59,608 --> 03:04:01,710
I THINK IT'S IMPORTANT TO

4573
03:04:01,710 --> 03:04:06,982
REALIZE THAT AS LONG AS HUMAN

4574
03:04:06,982 --> 03:04:09,251
BEINGS HAVE BEEN -- HAD

4575
03:04:09,251 --> 03:04:11,386
COGNITION AND THINKING THERE'S

4576
03:04:11,386 --> 03:04:12,053
BEEN DISCUSSIONS OF WHAT DO YOU

4577
03:04:12,053 --> 03:04:13,989
MEAN TO HAVE A MACHINE THAT

4578
03:04:13,989 --> 03:04:18,660
COULD REPRODUCE THE WAY WE

4579
03:04:18,660 --> 03:04:21,096
THINK, SO BACK IN THE 1800s A

4580
03:04:21,096 --> 03:04:22,764
NUMBER OF PEOPLE THOUGHT ABOUT

4581
03:04:22,764 --> 03:04:25,934
THIS FROM A MATHEMATICAL

4582
03:04:25,934 --> 03:04:26,434
STANDPOINT.

4583
03:04:26,434 --> 03:04:28,470
A LOT OF LOGIC MODELS CAME OUT

4584
03:04:28,470 --> 03:04:30,405
IN THAT POINT IN TIME.

4585
03:04:30,405 --> 03:04:32,374
MOVING THROUGH INTO THE

4586
03:04:32,374 --> 03:04:35,677
BEGINNING OF THE '60s WHEN I

4587
03:04:35,677 --> 03:04:38,380
WOULD SAY COMPUTERS AS WE THINK

4588
03:04:38,380 --> 03:04:39,948
OF TODAY WERE STARTING.

4589
03:04:39,948 --> 03:04:41,149
THERE WERE APPROACHES TO

4590
03:04:41,149 --> 03:04:43,118
THINKING ABOUT A.I. THEN, BUT OF

4591
03:04:43,118 --> 03:04:44,119
COURSE WE DIDN'T HAVE THE

4592
03:04:44,119 --> 03:04:47,489
COMPUTE CAPABILITY TO MAKE ANY

4593
03:04:47,489 --> 03:04:49,891
OF IT REALLY FEEL AND ACT LIKE A

4594
03:04:49,891 --> 03:04:50,225
PERSON.

4595
03:04:50,225 --> 03:05:00,735
BACK IN THE '40s THERE WAS THE

4596
03:05:04,873 --> 03:05:06,241
TURING TEST, CAN YOU PREDICT IF

4597
03:05:06,241 --> 03:05:11,846
IT'S A REAL PERSON, AND 2018

4598
03:05:11,846 --> 03:05:13,815
FOLKS AT GOOGLE WITH TRANSFORMER

4599
03:05:13,815 --> 03:05:17,285
MODELS, BERT IN PARTICULAR.

4600
03:05:17,285 --> 03:05:21,256
NOW WE HAVE LARGE LANGUAGE

4601
03:05:21,256 --> 03:05:21,990
MODELS, ChatGPT, CHANGING WAIT

4602
03:05:21,990 --> 03:05:23,992
WE THINK ABOUT A.I. AND THINKING

4603
03:05:23,992 --> 03:05:27,595
ABOUT THEM BEING RELEVANT TO OUR

4604
03:05:27,595 --> 03:05:27,962
DAY-TO-DAY LIFE.

4605
03:05:27,962 --> 03:05:29,564
SO, THAT'S KIND OF THE HISTORY

4606
03:05:29,564 --> 03:05:33,001
AND MAYBE A LITTLE BIT OF WHERE

4607
03:05:33,001 --> 03:05:33,735
WE'RE HEADING.

4608
03:05:33,735 --> 03:05:36,037
BUT I THINK IT'S REALLY

4609
03:05:36,037 --> 03:05:37,906
IMPORTANT THAT WHEN WE'RE

4610
03:05:37,906 --> 03:05:39,674
THINKING ABOUT A.I., ONE IS

4611
03:05:39,674 --> 03:05:42,077
THERE'S THIS CONCEPT OF BEING

4612
03:05:42,077 --> 03:05:45,347
A.I. READY.

4613
03:05:45,347 --> 03:05:49,517
SO, ARE THE DATA -- IS IT

4614
03:05:49,517 --> 03:05:52,554
SOMETHING THAT WE CAN -- WE CAN

4615
03:05:52,554 --> 03:05:54,422
USE THESE MODELS FOR, RIGHT?

4616
03:05:54,422 --> 03:05:56,191
ARE THE DATA APPROPRIATE?

4617
03:05:56,191 --> 03:05:57,692
DO WE HAVE GOOD DATA?

4618
03:05:57,692 --> 03:06:00,562
AND CAN WE USE THAT TO FEED INTO

4619
03:06:00,562 --> 03:06:01,429
A.I. SYSTEMS?

4620
03:06:01,429 --> 03:06:04,399
I THINK WHAT'S REALLY IMPORTANT

4621
03:06:04,399 --> 03:06:06,668
THERE -- OOPS, APPARENTLY I

4622
03:06:06,668 --> 03:06:08,103
MOVED THE SLIDE FORWARD.

4623
03:06:08,103 --> 03:06:09,437
WHAT'S REALLY IMPORTANT IN

4624
03:06:09,437 --> 03:06:11,806
THINKING ABOUT A.I. READY IS THE

4625
03:06:11,806 --> 03:06:12,941
DATA QUALITY HAS TO BE THERE,

4626
03:06:12,941 --> 03:06:15,210
AND IT HAS TO BE VALUABLE FOR

4627
03:06:15,210 --> 03:06:18,713
MANY, MANY THINGS, NOT JUST A.I.

4628
03:06:18,713 --> 03:06:21,116
SO, THAT'S ONE OF THE

4629
03:06:21,116 --> 03:06:21,649
PRINCIPLES.

4630
03:06:21,649 --> 03:06:22,751
ANOTHER ONE IS THINKING ABOUT

4631
03:06:22,751 --> 03:06:25,820
HOW DO WE MAKE SURE IN FACT THE

4632
03:06:25,820 --> 03:06:27,889
SYSTEMS WE BUILD, THE KINDS OF

4633
03:06:27,889 --> 03:06:29,991
DECISIONS THAT THEY MAKE, ARE

4634
03:06:29,991 --> 03:06:30,959
TRUSTWORTHY AND ETHICAL.

4635
03:06:30,959 --> 03:06:32,594
AND THAT'S REALLY A HUMAN

4636
03:06:32,594 --> 03:06:32,827
PROBLEM.

4637
03:06:32,827 --> 03:06:34,129
IT'S NOT AN A.I. PROBLEM.

4638
03:06:34,129 --> 03:06:38,266
IT'S HOW DO WE MAKE SURE WE'RE

4639
03:06:38,266 --> 03:06:39,434
REALLY PUTTING HUMAN BEINGS IN

4640
03:06:39,434 --> 03:06:43,638
THE LOOP IN DECISION MAKING.

4641
03:06:43,638 --> 03:06:45,407
DIVERSE WORKFORCE, WE'VE ALREADY

4642
03:06:45,407 --> 03:06:47,909
HAD DISCUSSIONS ABOUT THAT THIS

4643
03:06:47,909 --> 03:06:48,410
MORNING.

4644
03:06:48,410 --> 03:06:49,778
IT'S INCREDIBLY IMPORTANT AND

4645
03:06:49,778 --> 03:06:52,180
BOTH AROUND WHO COMES UP WITH

4646
03:06:52,180 --> 03:06:54,749
THE NEXT SETS OF A.I. MODELS BUT

4647
03:06:54,749 --> 03:06:57,552
ALSO HOW DO WE PREPARE EXISTING

4648
03:06:57,552 --> 03:06:59,187
WORKFORCE SO IN FACT THEY KNOW

4649
03:06:59,187 --> 03:07:00,789
HOW TO USE THE TOOLS THAT ARE

4650
03:07:00,789 --> 03:07:05,326
COMING OUT.

4651
03:07:05,326 --> 03:07:06,861
SO, IT'S REALLY -- THE WORKFORCE

4652
03:07:06,861 --> 03:07:08,062
PART IS REALLY IMPORTANT, AND

4653
03:07:08,062 --> 03:07:10,565
THAT'S SOMETHING THAT I'D LOVE

4654
03:07:10,565 --> 03:07:12,834
TO TALK MORE WITH YOU AT THE END

4655
03:07:12,834 --> 03:07:16,037
OF THE PRESENTATIONS.

4656
03:07:16,037 --> 03:07:20,208
SO, PREPARING FOR THE NEXT TWO

4657
03:07:20,208 --> 03:07:21,743
PRESENTATIONS, ONE IS THE

4658
03:07:21,743 --> 03:07:23,144
OPPORTUNITIES AROUND A.I. ARE,

4659
03:07:23,144 --> 03:07:25,346
ONE, HOW DO WE START TO

4660
03:07:25,346 --> 03:07:27,115
INTEGRATE GENERALIST A.I. MODELS

4661
03:07:27,115 --> 03:07:30,919
INTO EVERYTHING WE DO IN CANCER

4662
03:07:30,919 --> 03:07:31,252
RESEARCH?

4663
03:07:31,252 --> 03:07:34,289
SO, PART OF THAT, IN MY MIND, IS

4664
03:07:34,289 --> 03:07:35,857
THINKING ABOUT WHAT A LOT OF THE

4665
03:07:35,857 --> 03:07:36,825
BIG TECH COMPANIES ARE DOING

4666
03:07:36,825 --> 03:07:38,526
RIGHT NOW WHERE THEY ARE

4667
03:07:38,526 --> 03:07:42,664
GENERATING AND PUTTING A LOT OF

4668
03:07:42,664 --> 03:07:44,399
RESOURCES INTO NEW GENERATIVE

4669
03:07:44,399 --> 03:07:47,135
A.I. MODELS, NEW A.I.

4670
03:07:47,135 --> 03:07:47,469
ALGORITHMS.

4671
03:07:47,469 --> 03:07:50,872
HOW DO WE HELP THEM APPLY THAT

4672
03:07:50,872 --> 03:07:52,307
IN CANCER RESEARCH?

4673
03:07:52,307 --> 03:07:53,708
ANOTHER IS HOW DO WE JUST

4674
03:07:53,708 --> 03:07:55,143
COORDINATE ALL THE THINGS GOING

4675
03:07:55,143 --> 03:07:57,212
ON RIGHT NOW AND MAKE SURE THAT

4676
03:07:57,212 --> 03:07:59,514
WE'RE REALLY THINKING ABOUT IT

4677
03:07:59,514 --> 03:08:01,516
AS AN ECOSYSTEM, THINKING ABOUT

4678
03:08:01,516 --> 03:08:04,686
ALL THE POSSIBILITIES TOGETHER.

4679
03:08:04,686 --> 03:08:07,422
AND I THINK YOU'RE GOING TO HEAR

4680
03:08:07,422 --> 03:08:09,958
EXAMPLES FROM JULIE, AND

4681
03:08:09,958 --> 03:08:11,125
EXAMPLES FROM BARIS HOW WE DO

4682
03:08:11,125 --> 03:08:11,459
THAT.

4683
03:08:11,459 --> 03:08:15,296
I'M GOING TO TURN THIS OVER TO

4684
03:08:15,296 --> 03:08:17,499
JULIE, AND LET HER TALK ABOUT

4685
03:08:17,499 --> 03:08:21,002
THE A.I. WORKING GROUP.

4686
03:08:21,002 --> 03:08:22,837
AND THIS DID SEEM TO WORK FOR

4687
03:08:22,837 --> 03:08:23,004
ME.

4688
03:08:23,004 --> 03:08:25,240
>> OKAY, GREAT.

4689
03:08:25,240 --> 03:08:26,007
THANK YOU, WARREN.

4690
03:08:26,007 --> 03:08:30,612
IT'S A PLEASURE TO BE HERE TODAY

4691
03:08:30,612 --> 03:08:32,547
REPRESENTING THE NCI ARTIFICIAL

4692
03:08:32,547 --> 03:08:34,682
INTELLIGENCE WORKING GROUP.

4693
03:08:34,682 --> 03:08:37,051
SO, WE USE THE TERM ARTIFICIAL

4694
03:08:37,051 --> 03:08:40,388
INTELLIGENCE REALLY TO DESCRIBE

4695
03:08:40,388 --> 03:08:41,756
A VERY BROAD COLLECTION OF

4696
03:08:41,756 --> 03:08:44,759
COMPUTER METHODS THAT CAN LEARN

4697
03:08:44,759 --> 03:08:47,362
PATTERNS IN DATA THAT MIMIC THE

4698
03:08:47,362 --> 03:08:48,796
HUMAN BRAIN.

4699
03:08:48,796 --> 03:08:51,299
AND THESE METHODS ARE

4700
03:08:51,299 --> 03:08:54,802
INCREASINGLY BEING APPLIED BY

4701
03:08:54,802 --> 03:08:55,270
CANCER RESEARCHERS AND

4702
03:08:55,270 --> 03:08:57,872
CLINICIANS ACROSS THE WHOLE

4703
03:08:57,872 --> 03:08:59,173
SPECTRUM OF CANCER RESEARCH,

4704
03:08:59,173 --> 03:09:02,577
INCLUDING CANCER SCREENING AND

4705
03:09:02,577 --> 03:09:04,913
DIAGNOSIS, DRUG DISCOVERY,

4706
03:09:04,913 --> 03:09:06,414
CANCER SURVEILLANCE, HEALTHCARE

4707
03:09:06,414 --> 03:09:12,987
DELIVERY, AS WELL AS TO DERIVE

4708
03:09:12,987 --> 03:09:13,855
MECHANISTIC INSIGHTS INTO

4709
03:09:13,855 --> 03:09:14,822
CANCER.

4710
03:09:14,822 --> 03:09:16,391
AT THE NIH ELEMENTS OF

4711
03:09:16,391 --> 03:09:17,692
ARTIFICIAL INTELLIGENCE ARE

4712
03:09:17,692 --> 03:09:21,296
REALLY EMBEDDED ACROSS OUR WHOLE

4713
03:09:21,296 --> 03:09:22,931
PORTFOLIO OF GRANTS AND

4714
03:09:22,931 --> 03:09:25,667
CONTRACTS, AS CANCER RESEARCHERS

4715
03:09:25,667 --> 03:09:28,970
ARE INCREASINGLY USING THESE

4716
03:09:28,970 --> 03:09:33,875
METHODS IN THEIR RESEARCH

4717
03:09:33,875 --> 03:09:34,742
ACTIVITIES.

4718
03:09:34,742 --> 03:09:36,611
THIS GRAPH SHOWS ABOUT 300

4719
03:09:36,611 --> 03:09:39,113
GRANTS THAT RECEIVE FUNDING IN

4720
03:09:39,113 --> 03:09:42,183
FY 23 THAT HAVE SIGNIFICANT

4721
03:09:42,183 --> 03:09:43,051
COMPONENTS OF ARTIFICIAL

4722
03:09:43,051 --> 03:09:44,385
INTELLIGENCE OR WE OFTEN REFER

4723
03:09:44,385 --> 03:09:47,388
TO IT AS MACHINE LEARNING.

4724
03:09:47,388 --> 03:09:49,857
AND YOU CAN SEE THAT IT'S BEING

4725
03:09:49,857 --> 03:09:52,360
APPLIED ACROSS THE SPECTRUM OF

4726
03:09:52,360 --> 03:09:53,461
CANCER RESEARCH AT NCI.

4727
03:09:53,461 --> 03:09:56,431
TO GIVE A SENSE OF THE BREADTH

4728
03:09:56,431 --> 03:10:02,103
OF NCI'S SUPPORT TODAY.

4729
03:10:02,103 --> 03:10:07,141
SO, BACK IN 2020, NCI STARTED

4730
03:10:07,141 --> 03:10:08,242
THE TRANSNCI ARTIFICIAL

4731
03:10:08,242 --> 03:10:10,011
INTELLIGENCE WORKING GROUP WITH

4732
03:10:10,011 --> 03:10:11,412
THE REALIZATION WE NEEDED A

4733
03:10:11,412 --> 03:10:13,715
GROUP WHO COULD PROVIDE A HUB

4734
03:10:13,715 --> 03:10:14,215
FOR COMMUNICATION AND

4735
03:10:14,215 --> 03:10:17,452
COORDINATION OF A.I.-RELATED

4736
03:10:17,452 --> 03:10:19,721
SCIENTIFIC PROJECTS AND PROGRAMS

4737
03:10:19,721 --> 03:10:20,054
ACROSS NCI.

4738
03:10:20,054 --> 03:10:24,759
AND WHO COULD WORK TO IDENTIFY

4739
03:10:24,759 --> 03:10:25,627
TRANSNCI CANCER RESEARCH

4740
03:10:25,627 --> 03:10:26,628
OPPORTUNITIES THAT COULD MOST

4741
03:10:26,628 --> 03:10:28,162
BENEFIT FROM THE APPROPRIATE USE

4742
03:10:28,162 --> 03:10:30,264
OF A.I.

4743
03:10:30,264 --> 03:10:34,502
AND ALSO TO SERVE AS A HUB FOR

4744
03:10:34,502 --> 03:10:35,403
CONNECTION AND COORDINATION WITH

4745
03:10:35,403 --> 03:10:37,038
A.I. ACTIVITIES OUTSIDE OF THE

4746
03:10:37,038 --> 03:10:37,705
NCI.

4747
03:10:37,705 --> 03:10:41,509
AND TODAY THIS WORKING GROUP

4748
03:10:41,509 --> 03:10:43,044
CONSISTS OF ALMOST 30 MEMBERS

4749
03:10:43,044 --> 03:10:48,516
REPRESENTING NEARLY ALL OF NCI'S

4750
03:10:48,516 --> 03:10:50,485
DIVISIONS, OFFICES AND CENTERS.

4751
03:10:50,485 --> 03:10:53,221
SOME ACTIVITIES THIS WORKING

4752
03:10:53,221 --> 03:10:54,322
GROUP CONSIDERS INCLUDE THE

4753
03:10:54,322 --> 03:10:57,625
RESEARCH ACTIVITIES EMBEDDED IN

4754
03:10:57,625 --> 03:10:58,926
OUR EXTRAMURAL GRANT PROGRAMS,

4755
03:10:58,926 --> 03:11:01,562
AS WELL AS THE RESEARCH GOING ON

4756
03:11:01,562 --> 03:11:02,997
IN OUR INTRAMURAL RESEARCH GROUP

4757
03:11:02,997 --> 03:11:06,467
THAT YOU'LL HEAR ABOUT FROM DR.

4758
03:11:06,467 --> 03:11:09,437
TURKBEY IN A FEW MINUTES.

4759
03:11:09,437 --> 03:11:11,172
ALSO, THE RESEARCH AND THE

4760
03:11:11,172 --> 03:11:13,174
RESOURCES THAT ARE BEING

4761
03:11:13,174 --> 03:11:15,343
GENERATED THROUGH OUR NOW

4762
03:11:15,343 --> 03:11:15,977
LONGSTANDING COLLABORATION WITH

4763
03:11:15,977 --> 03:11:18,312
THE DEPARTMENT OF ENERGY, AS

4764
03:11:18,312 --> 03:11:20,081
WELL AS THE DATA SCIENCE

4765
03:11:20,081 --> 03:11:22,050
INFRASTRUCTURE SUPPORTED THROUGH

4766
03:11:22,050 --> 03:11:23,785
THE CANCER RESEARCH DATA

4767
03:11:23,785 --> 03:11:24,018
COMMONS.

4768
03:11:24,018 --> 03:11:26,554
THE WORKING GROUP ALSO

4769
03:11:26,554 --> 03:11:30,224
COORDINATES OUR PARTICIPATION IN

4770
03:11:30,224 --> 03:11:31,659
BROADER NIH ARTIFICIAL

4771
03:11:31,659 --> 03:11:32,994
INTELLIGENCE ACTIVITIES,

4772
03:11:32,994 --> 03:11:35,496
PARTICULARLY THOSE COORDINATED

4773
03:11:35,496 --> 03:11:36,264
OUT OF THE NIH OFFICE OF DATA

4774
03:11:36,264 --> 03:11:39,100
SCIENCE STRATEGY, AS WELL AS

4775
03:11:39,100 --> 03:11:40,401
COMMON FUND ACTIVITIES SUCH AS

4776
03:11:40,401 --> 03:11:43,271
THE BRIDGE TO A.I. PROGRAM.

4777
03:11:43,271 --> 03:11:45,239
THE WORKING GROUP ALSO SERVES AS

4778
03:11:45,239 --> 03:11:48,843
A RESOURCE TO THE NCI'S

4779
03:11:48,843 --> 03:11:49,944
COMMUNICATIONS OFFICE,

4780
03:11:49,944 --> 03:11:52,146
GOVERNMENT RELATIONS OFFICE, AND

4781
03:11:52,146 --> 03:11:56,284
OFFICE OF ADVOCACY RELATIONS TO

4782
03:11:56,284 --> 03:11:57,618
PROVIDE SUPPORT FOR

4783
03:11:57,618 --> 03:11:58,386
COMMUNICATIONS, CONGRESSIONAL

4784
03:11:58,386 --> 03:12:00,354
BRIEFINGS, AND OTHER

4785
03:12:00,354 --> 03:12:01,656
A.I.-RELATED INQUIRIES THAT COME

4786
03:12:01,656 --> 03:12:03,191
TO THE NCI.

4787
03:12:03,191 --> 03:12:07,562
AND FINALLY, AND MORE BROADLY,

4788
03:12:07,562 --> 03:12:10,331
WE PARTICIPATE IN BROADER

4789
03:12:10,331 --> 03:12:10,932
TRANS-GOVERNMENTAL ACTIVITIES

4790
03:12:10,932 --> 03:12:12,400
INCLUDING THE A.I. COMPONENTS

4791
03:12:12,400 --> 03:12:15,903
THAT ARE EMBEDDED IN THE CANCER

4792
03:12:15,903 --> 03:12:18,206
MOONSHOT AND ARPA-H, WE

4793
03:12:18,206 --> 03:12:23,444
PARTICIPATE IN NSF PROGRAMS, AS

4794
03:12:23,444 --> 03:12:24,779
WELL AS BROADER HHS PROGRAMS.

4795
03:12:24,779 --> 03:12:29,383
SINCE THE WORKING GROUP STARTED,

4796
03:12:29,383 --> 03:12:32,320
BACK IN 2020, THE LATTER

4797
03:12:32,320 --> 03:12:34,222
PROVIDED COORDINATION FOR MANY

4798
03:12:34,222 --> 03:12:35,523
TRANS-NCI EFFORTS RELATED TO USE

4799
03:12:35,523 --> 03:12:38,259
OF A.I. IN CANCER RESEARCH, AND

4800
03:12:38,259 --> 03:12:41,429
THAT INCLUDES SEVERAL SAND

4801
03:12:41,429 --> 03:12:43,498
PIT-STYLE OR DISCUSSION FORUMS

4802
03:12:43,498 --> 03:12:46,667
WHERE WE'VE ENGAGED THE CANCER

4803
03:12:46,667 --> 03:12:47,902
COMMUNITY IN INTERACTIVE

4804
03:12:47,902 --> 03:12:50,838
SESSIONS ON KEY TOPICS AND A.I.,

4805
03:12:50,838 --> 03:12:52,440
SUCH AS DIGITAL TWINS, AND THE

4806
03:12:52,440 --> 03:12:56,244
USE OF ETHICAL A.I.

4807
03:12:56,244 --> 03:12:59,313
WE'VE ALSO HOSTED SEVERAL

4808
03:12:59,313 --> 03:13:02,917
WORKSHOPS ON EMERGING TOPICS IN

4809
03:13:02,917 --> 03:13:04,685
A.I. FOR CANCER RESEARCH,

4810
03:13:04,685 --> 03:13:08,055
INCLUDING ONE ON RADIATION

4811
03:13:08,055 --> 03:13:09,157
ONCOLOGY, HEALTHCARE DELIVERY,

4812
03:13:09,157 --> 03:13:11,659
AND MOST RECENTLY THROUGH THE

4813
03:13:11,659 --> 03:13:12,460
CANCER MOONSHOT WE HELD A

4814
03:13:12,460 --> 03:13:16,597
WORKSHOP ON USING A.I. TO TARGET

4815
03:13:16,597 --> 03:13:18,900
UNDRUGGABLE TARGETS, AND THIS

4816
03:13:18,900 --> 03:13:21,402
BROAD TOGETHER REPRESENTATIVES

4817
03:13:21,402 --> 03:13:22,837
FROM INDUSTRY, ACADEMIA, AND THE

4818
03:13:22,837 --> 03:13:25,006
GOVERNMENT, TO DISCUSS HOW WE

4819
03:13:25,006 --> 03:13:29,177
COULD COLLABORATE IN THIS SPACE.

4820
03:13:29,177 --> 03:13:29,944
WE'VE ALSO COORDINATED

4821
03:13:29,944 --> 03:13:32,580
PARTICIPATION IN A.I.-RELATED

4822
03:13:32,580 --> 03:13:35,216
FUNDING OPPORTUNITIES, INCLUDING

4823
03:13:35,216 --> 03:13:36,083
THOSE COORDINATED BY THE OFFICE

4824
03:13:36,083 --> 03:13:38,920
OF DATA SCIENCE STRATEGY, ON

4825
03:13:38,920 --> 03:13:42,423
A.I. DATA READINESS, ETHICAL

4826
03:13:42,423 --> 03:13:44,158
A.I., AND ADVANCING MULTI-MODAL

4827
03:13:44,158 --> 03:13:44,592
A.I.

4828
03:13:44,592 --> 03:13:48,229
AND EARLIER THIS YEAR THE NCI

4829
03:13:48,229 --> 03:13:50,298
HOSTED A PRIZE CHALLENGE ON

4830
03:13:50,298 --> 03:13:52,400
EVALUATING THE DATA IN THE

4831
03:13:52,400 --> 03:13:54,602
CANCER RESEARCH DATA COMMONS FOR

4832
03:13:54,602 --> 03:13:57,638
A.I. DATA READINESS.

4833
03:13:57,638 --> 03:14:00,374
AND FINALLY, RECOGNIZING THE

4834
03:14:00,374 --> 03:14:01,375
NEED FOR INCREASED TRANSPARENCY

4835
03:14:01,375 --> 03:14:03,344
AND UNDERSTANDING OF THESE

4836
03:14:03,344 --> 03:14:05,613
MODELS, WE RECENTLY ADDED NEW

4837
03:14:05,613 --> 03:14:08,416
MODEL SHARING REQUIREMENTS TO

4838
03:14:08,416 --> 03:14:09,450
OUR INFORMATICS FUNDING

4839
03:14:09,450 --> 03:14:12,386
OPPORTUNITIES.

4840
03:14:12,386 --> 03:14:15,122
TO MEET THE INCREASING INTEREST

4841
03:14:15,122 --> 03:14:16,891
IN INFORMATION ABOUT HOW

4842
03:14:16,891 --> 03:14:17,758
ARTIFICIAL INTELLIGENCE IS

4843
03:14:17,758 --> 03:14:18,860
ADVANCING CANCER RESEARCH, WE

4844
03:14:18,860 --> 03:14:23,564
RECENTLY STOOD UP TWO NEW

4845
03:14:23,564 --> 03:14:26,534
WEBSITES ON NCI'S WEB PRESENCE

4846
03:14:26,534 --> 03:14:27,401
cancer.gov TO PROVIDE

4847
03:14:27,401 --> 03:14:29,604
INFORMATION ABOUT NCI'S

4848
03:14:29,604 --> 03:14:30,271
ACTIVITIES.

4849
03:14:30,271 --> 03:14:32,006
ONE SITE IS DIRECTED AT THE

4850
03:14:32,006 --> 03:14:33,875
PUBLIC TO DESCRIBE ONGOING

4851
03:14:33,875 --> 03:14:35,243
OPPORTUNITIES AND RESEARCH AND

4852
03:14:35,243 --> 03:14:36,477
SHOWING WAYS THAT ARTIFICIAL

4853
03:14:36,477 --> 03:14:39,113
INTELLIGENCE IS BEING APPLIED IN

4854
03:14:39,113 --> 03:14:40,748
VARIOUS ASPECTS OF CANCER

4855
03:14:40,748 --> 03:14:41,315
RESEARCH.

4856
03:14:41,315 --> 03:14:43,384
A SECOND PAGE DIRECTED AT

4857
03:14:43,384 --> 03:14:46,988
RESEARCHERS WHO ARE LOOKING FOR

4858
03:14:46,988 --> 03:14:48,089
FUNDING OPPORTUNITIES, EVENTS,

4859
03:14:48,089 --> 03:14:50,791
RESOURCES TO ADVANCE THEIR USE

4860
03:14:50,791 --> 03:14:51,826
OF A.I. IN CANCER.

4861
03:14:51,826 --> 03:14:53,327
AND WITH THAT, I'M GOING TO HAND

4862
03:14:53,327 --> 03:14:56,731
IT OVER TO DR. TURKBEY TO TALK

4863
03:14:56,731 --> 03:14:58,566
ABOUT RESEARCH GOING ON IN THE

4864
03:14:58,566 --> 03:15:04,605
CENTER FOR CANCER RESEARCH.

4865
03:15:04,605 --> 03:15:06,040
>> ALL RIGHT.

4866
03:15:06,040 --> 03:15:08,209
GOOD AFTERNOON, AND THANK YOU

4867
03:15:08,209 --> 03:15:10,978
FOR THIS OPPORTUNITY TO

4868
03:15:10,978 --> 03:15:16,884
COMMUNICATE OUR  RESEARCH.

4869
03:15:16,884 --> 03:15:19,086
OUR MISSION IS TO DEVELOP

4870
03:15:19,086 --> 03:15:22,790
TRANSLATIONAL A.I. MODELS TO

4871
03:15:22,790 --> 03:15:25,092
ENHANCE IMAGING-BASED RESEARCH

4872
03:15:25,092 --> 03:15:29,797
OF RESEARCHERS WITHIN NIH AND

4873
03:15:29,797 --> 03:15:33,834
SOMETIMES OUTSIDE NIH.

4874
03:15:33,834 --> 03:15:36,070
OUR PORTFOLIO IS DIVERSE,

4875
03:15:36,070 --> 03:15:38,105
COVERING CLINICAL RESEARCH AND

4876
03:15:38,105 --> 03:15:43,344
WE'RE DOING THIS RESEARCH IS

4877
03:15:43,344 --> 03:15:44,879
ALSO DIVERSE, RADIOLOGY, DIGITAL

4878
03:15:44,879 --> 03:15:47,481
PATHOLOGY, AS YOU CAN SEE LIKE

4879
03:15:47,481 --> 03:15:50,351
SEVERAL DIFFERENT MODALITIES ARE

4880
03:15:50,351 --> 03:15:52,386
INCLUDED IN OUR RESEARCH.

4881
03:15:52,386 --> 03:15:54,288
IN THE NEXT FEW SLIDES I WOULD

4882
03:15:54,288 --> 03:15:57,258
LIKE TO SHOW HOW WE CONDUCT

4883
03:15:57,258 --> 03:16:00,394
RESEARCH WITH ONE SINGLE

4884
03:16:00,394 --> 03:16:00,628
EXAMPLE.

4885
03:16:00,628 --> 03:16:02,496
FOR A SUCCESSFUL A.I. PROJECT

4886
03:16:02,496 --> 03:16:04,398
YOU NEED TO HAVE A GOOD RESEARCH

4887
03:16:04,398 --> 03:16:05,766
QUESTION OR A PROBLEM.

4888
03:16:05,766 --> 03:16:09,937
SO IN THIS CASE OUR PROBLEM IS

4889
03:16:09,937 --> 03:16:12,406
INCONSISTENT DIAGNOSIS FOR

4890
03:16:12,406 --> 03:16:13,641
PROSTATE MRI FOR DETECTING

4891
03:16:13,641 --> 03:16:15,376
PROSTATE CANCERS.

4892
03:16:15,376 --> 03:16:16,010
WE PUBLISHED THIS RESEARCH IN

4893
03:16:16,010 --> 03:16:20,214
2018 AND AS YOU CAN SEE THERE

4894
03:16:20,214 --> 03:16:21,515
ARE SIX RADIOLOGISTS, THEY

4895
03:16:21,515 --> 03:16:22,817
OUTLINED DIFFERENT AREAS ON THE

4896
03:16:22,817 --> 03:16:27,321
SAME PATIENT IMAGES, A BIG

4897
03:16:27,321 --> 03:16:28,823
CONSISTENCY STILL GOING ON.

4898
03:16:28,823 --> 03:16:32,360
THE QUESTION FOR A.I. CAN A

4899
03:16:32,360 --> 03:16:35,396
FULLY AUTOMATED MODEL SOLVE THIS

4900
03:16:35,396 --> 03:16:35,763
PROBLEM?

4901
03:16:35,763 --> 03:16:37,698
WITH THIS MOTIVATION UTILIZE OUR

4902
03:16:37,698 --> 03:16:39,767
INTRAMURAL DATA PLUS WE GET DATA

4903
03:16:39,767 --> 03:16:41,869
FROM OUTSIDE NIH, AND WE BUILD

4904
03:16:41,869 --> 03:16:44,171
UP A CASCADED MODEL, FULLY

4905
03:16:44,171 --> 03:16:47,575
AUTOMATED MODEL WHICH HANDLES

4906
03:16:47,575 --> 03:16:50,311
THESE IMAGES ON ITS OWN.

4907
03:16:50,311 --> 03:16:54,782
WITHOUT GOING INTO DETAIL, THE

4908
03:16:54,782 --> 03:16:58,819
MODELS FINDING CANCER IS 63%,

4909
03:16:58,819 --> 03:17:00,388
AVERAGE ACADEMIC RADIOLOGIST IS

4910
03:17:00,388 --> 03:17:04,859
40%, IF THIS IS EXPECTED TO

4911
03:17:04,859 --> 03:17:08,562
INCREASE, THIS TOOL IS GIVING

4912
03:17:08,562 --> 03:17:10,197
ONE FALSE POSITIVE EVERY OTHER

4913
03:17:10,197 --> 03:17:11,866
PATIENT, WE WANT MODELS TO BE

4914
03:17:11,866 --> 03:17:13,167
TRANSLATIONAL, WE WANT THEM TO

4915
03:17:13,167 --> 03:17:14,935
BE ALIVE IN OUR CLINICAL AND

4916
03:17:14,935 --> 03:17:16,904
RESEARCH ENVIRONMENT SO WE

4917
03:17:16,904 --> 03:17:20,207
DEPLOY THIS MODEL INTO OUR

4918
03:17:20,207 --> 03:17:21,175
HOSPITAL, AND NIH CLINICAL

4919
03:17:21,175 --> 03:17:22,276
CENTERS ENVIRONMENT.

4920
03:17:22,276 --> 03:17:25,346
WHAT HAPPENS IS THE USER SELECTS

4921
03:17:25,346 --> 03:17:26,981
THESE THREE IMAGING SEQUENCES

4922
03:17:26,981 --> 03:17:29,050
AND PUSHES THIS BUTTON, AND THEN

4923
03:17:29,050 --> 03:17:32,887
THE MODEL STARTS TO WORK BEHIND

4924
03:17:32,887 --> 03:17:37,058
THE SCENES WE USE A PROCESS

4925
03:17:37,058 --> 03:17:41,762
CALLED MONI, DETECTING THE

4926
03:17:41,762 --> 03:17:43,931
SEQUENCES, FINES THE ORGAN,

4927
03:17:43,931 --> 03:17:45,900
MATCHES, OUTLINES THE CANCER

4928
03:17:45,900 --> 03:17:46,801
SUSPICIOUS AREAS.

4929
03:17:46,801 --> 03:17:48,135
WITHIN ONE MINUTE AND 20 SECONDS

4930
03:17:48,135 --> 03:17:50,538
THIS DATA IS PUSHED BACK INTO

4931
03:17:50,538 --> 03:17:52,139
THE HOSPITAL SYSTEM, AND THIS IS

4932
03:17:52,139 --> 03:17:53,040
ONE OF THE EXAMPLES.

4933
03:17:53,040 --> 03:17:55,676
THE TOP ROW IS THE NAIVE IMAGES,

4934
03:17:55,676 --> 03:17:58,712
I READ THIS PATIENT AS NEGATIVE.

4935
03:17:58,712 --> 03:18:00,448
AND A.I. MODEL FOUND LESION IN

4936
03:18:00,448 --> 03:18:01,982
THE RIGHT PERIPHERAL ZONE OF

4937
03:18:01,982 --> 03:18:04,285
THIS PATIENT AND THIS WAS A

4938
03:18:04,285 --> 03:18:09,657
GLEASON GRADE 4.

4939
03:18:09,657 --> 03:18:16,897
GLEASON 4 PLUS  CARS NO,  -- CA.

4940
03:18:16,897 --> 03:18:19,066
WE DON'T CLAIM ANY OWNERSHIP SO

4941
03:18:19,066 --> 03:18:20,935
WE OPEN SOURCE OUR MODEL,

4942
03:18:20,935 --> 03:18:22,369
CURRENTLY THIS MODEL IS

4943
03:18:22,369 --> 03:18:23,471
PROSPECTIVELY USED IN GUIDING

4944
03:18:23,471 --> 03:18:25,106
BIOPSIES FOR THE LAST THREE

4945
03:18:25,106 --> 03:18:28,442
MONTHS, AND I JUST RECEIVED

4946
03:18:28,442 --> 03:18:29,910
RESULTS, DETECTION CAPABILITIES

4947
03:18:29,910 --> 03:18:32,313
80% IN OUR OWN PATIENT

4948
03:18:32,313 --> 03:18:33,080
POPULATION.

4949
03:18:33,080 --> 03:18:36,817
WE ALSO USED IT FOR RADIOTHERAPY

4950
03:18:36,817 --> 03:18:37,818
GUIDANCE AND PSYCHOTHERAPY

4951
03:18:37,818 --> 03:18:38,085
GUIDANCE.

4952
03:18:38,085 --> 03:18:39,887
MODELS AVAILABLE TO THE WORLD,

4953
03:18:39,887 --> 03:18:41,088
THESE ARE THE PLACES CURRENTLY

4954
03:18:41,088 --> 03:18:42,523
DOWNLOAD IT AND UTILIZE THE

4955
03:18:42,523 --> 03:18:44,158
MODEL FOR THEIR RESEARCH AND

4956
03:18:44,158 --> 03:18:45,359
CLINICAL PRACTICE.

4957
03:18:45,359 --> 03:18:47,862
AND WE WORK WITH EUROPEAN UNION

4958
03:18:47,862 --> 03:18:51,165
COLLEAGUES TO HAVE THIS MODEL AS

4959
03:18:51,165 --> 03:18:53,067
A BASE FOR FEDERATED LEARNING

4960
03:18:53,067 --> 03:18:55,202
PROJECT, THE HOPE TO TAKE A

4961
03:18:55,202 --> 03:19:01,442
MODEL TO AFRICA WHICH HAS A  A

4962
03:19:01,442 --> 03:19:02,276
LOW-RESOURCE SETTING AS YOU

4963
03:19:02,276 --> 03:19:02,543
KNOW.

4964
03:19:02,543 --> 03:19:05,713
A.I. IN OUR WORLD IS VERY

4965
03:19:05,713 --> 03:19:07,681
DIVERSE.

4966
03:19:07,681 --> 03:19:10,951
OUR PROJECT IS NOT POSSIBLE,

4967
03:19:10,951 --> 03:19:12,620
THREE BASIC TEAMS, PRODUCTIVITY,

4968
03:19:12,620 --> 03:19:13,487
LIKE OBJECT DETECTION-BASED

4969
03:19:13,487 --> 03:19:16,090
PROJECTS. 

4970
03:19:16,090 --> 03:19:19,393
AS YOU CAN SEE WE BUILD SOME

4971
03:19:19,393 --> 03:19:22,563
MODELS FOR RESEARCH TO CALCULATE

4972
03:19:22,563 --> 03:19:23,898
BASELINE AND TREATMENT FOLLOW-UP

4973
03:19:23,898 --> 03:19:25,065
TUMOR BURDEN.

4974
03:19:25,065 --> 03:19:26,600
SECOND TEAM IS DIAGNOSTIC

4975
03:19:26,600 --> 03:19:28,569
ASSISTANCE, WE BUILD UP THIS

4976
03:19:28,569 --> 03:19:34,041
MODEL TO FIND SOLID CYSTIC SOLID

4977
03:19:34,041 --> 03:19:35,376
AND NORMAL KIDNEY PARENCHYMA.

4978
03:19:35,376 --> 03:19:40,848
THE FINAL IS MORE CHALLENGING

4979
03:19:40,848 --> 03:19:42,483
THING, BIOMARKER DISCOVERY, A

4980
03:19:42,483 --> 03:19:44,652
COOPERATION, SO WE BUILD THE

4981
03:19:44,652 --> 03:19:47,521
MODEL WHICH CAN FIND ASSOCIATION

4982
03:19:47,521 --> 03:19:48,255
WITHIN HISTOPATHOLOGY IMAGES,

4983
03:19:48,255 --> 03:19:50,457
IMAGES WHICH TELLS US WHICH

4984
03:19:50,457 --> 03:19:52,993
AREAS ARE ASSOCIATED WITH

4985
03:19:52,993 --> 03:19:55,930
METASTASIS AND BIOCHEMICAL

4986
03:19:55,930 --> 03:19:56,463
RECURRENCE.

4987
03:19:56,463 --> 03:19:58,132
SO, OVERALL WE ARE VERY CAREFUL

4988
03:19:58,132 --> 03:19:59,333
ABOUT DEPLOYING OUR MODELS.

4989
03:19:59,333 --> 03:20:01,068
WE WANT MODELS TO BE ALIVE.

4990
03:20:01,068 --> 03:20:04,405
WE WANT THESE MODELS TO BE USED

4991
03:20:04,405 --> 03:20:06,340
IN CLINICAL AND RESEARCH

4992
03:20:06,340 --> 03:20:06,607
PURPOSES.

4993
03:20:06,607 --> 03:20:08,642
ALSO WE TRAIN OUR OWN FELLOWS

4994
03:20:08,642 --> 03:20:10,811
AND RESEARCHERS WHO APPLY TO US

4995
03:20:10,811 --> 03:20:13,881
TO MAKE SURE THAT THEY HAVE GOOD

4996
03:20:13,881 --> 03:20:15,316
COMPUTATIONAL CAPABILITIES FOR

4997
03:20:15,316 --> 03:20:16,250
THEIR FUTURE RESEARCH.

4998
03:20:16,250 --> 03:20:17,484
THIS IS MY TEAM.

4999
03:20:17,484 --> 03:20:18,919
ON BEHALF OF MY TEAM I WOULD

5000
03:20:18,919 --> 03:20:21,121
LIKE TO THANK YOU ALL FOR

5001
03:20:21,121 --> 03:20:23,857
LETTING ME TO PRESENT SOME OF

5002
03:20:23,857 --> 03:20:25,059
OUR RESEARCH HERE, AND, AGAIN,

5003
03:20:25,059 --> 03:20:26,493
THIS WAS AN IMPORTANT

5004
03:20:26,493 --> 03:20:30,431
OPPORTUNITY FOR ME. 

5005
03:20:30,431 --> 03:20:32,533
THANK YOU SO MUCH.

5006
03:20:32,533 --> 03:20:38,839
[APPLAUSE] 

5007
03:20:38,839 --> 03:20:40,074
>> FANTASTIC.

5008
03:20:40,074 --> 03:20:42,776
>> A CASE OF WHAT WE'RE
DOING.

5009
03:20:42,776 --> 03:20:44,511
>> YEAH, I WAS FASCINATED,

5010
03:20:44,511 --> 03:20:46,814
WONDERFUL TO SEE -- WELL, GREAT

5011
03:20:46,814 --> 03:20:48,148
PRESENTATION, WONDERFUL TO SEE

5012
03:20:48,148 --> 03:20:48,916
THE PARTNERSHIPS.

5013
03:20:48,916 --> 03:20:50,651
I MAY HAVE MISSED BUT ONE I

5014
03:20:50,651 --> 03:20:53,187
DIDN'T SEE WAS NCI FREDERICK, OR

5015
03:20:53,187 --> 03:20:57,157
FREDERICK NATIONAL LABS.

5016
03:20:57,157 --> 03:20:58,025
ARE THERE ANY ACTIVITIES THERE,

5017
03:20:58,025 --> 03:21:01,462
IT SEEMS LIKE SOME OF THIS

5018
03:21:01,462 --> 03:21:03,264
ACTUALLY COULD BE MORE SERVICE

5019
03:21:03,264 --> 03:21:05,799
OPPORTUNITIES FOR INDIVIDUALS

5020
03:21:05,799 --> 03:21:07,434
OUTSIDE TO LEVERAGE AND I WONDER

5021
03:21:07,434 --> 03:21:08,535
IF THERE'S ANYTHING HAPPENING

5022
03:21:08,535 --> 03:21:11,405
THERE THAT YOU GUYS COULD TALK

5023
03:21:11,405 --> 03:21:11,772
ABOUT.

5024
03:21:11,772 --> 03:21:13,140
>> WELL, SO FIRST, ALMOST

5025
03:21:13,140 --> 03:21:17,411
EVERYTHING WE DO AT DOE, AT

5026
03:21:17,411 --> 03:21:18,479
LEAST TOUCHES FREDERICK AT SOME

5027
03:21:18,479 --> 03:21:18,679
LEVEL.

5028
03:21:18,679 --> 03:21:19,747
THEY ARE THE POINT OF

5029
03:21:19,747 --> 03:21:24,385
INTERACTION WITH A LOT OF DOE

5030
03:21:24,385 --> 03:21:25,486
FOLKS BETWEEN -- WITH NCI.

5031
03:21:25,486 --> 03:21:27,921
THANKING ABOUT THE RAS

5032
03:21:27,921 --> 03:21:28,656
INITIATIVE, THEY REALLY -- THEY

5033
03:21:28,656 --> 03:21:33,027
DO SO MUCH A.I. WORK OUT THERE

5034
03:21:33,027 --> 03:21:37,431
WITH THE RAS INITIATIVE.

5035
03:21:37,431 --> 03:21:39,400
BUT JULI, DO YOU WANT TO TALK

5036
03:21:39,400 --> 03:21:41,135
ABOUT TEAMS FOCUSED INTERNALLY

5037
03:21:41,135 --> 03:21:41,568
AT FREDERICK?

5038
03:21:41,568 --> 03:21:43,404
>> YEAH, SO MUCH GOING ON.

5039
03:21:43,404 --> 03:21:50,344
THE OTHER RESOURCE I WANTED TO

5040
03:21:50,344 --> 03:21:53,714
MENTION THAT WAS A NEW SITE I

5041
03:21:53,714 --> 03:21:54,615
THINK CALLED COMPUTATIONAL

5042
03:21:54,615 --> 03:21:55,816
RESOURCES, IT'S A PLACE WHERE

5043
03:21:55,816 --> 03:21:58,552
THEY ARE NOW SHARING THE MODELS

5044
03:21:58,552 --> 03:22:00,187
AND THE DATASETS THAT THOSE

5045
03:22:00,187 --> 03:22:01,922
MODELS WERE TRAINED ON PUBLICLY

5046
03:22:01,922 --> 03:22:03,223
THROUGH THIS RESOURCE WITH THE

5047
03:22:03,223 --> 03:22:05,426
GOAL IT CAN ULTIMATELY BE A

5048
03:22:05,426 --> 03:22:07,428
RESOURCE WHERE OTHERS CAN SHARE

5049
03:22:07,428 --> 03:22:09,830
THEIR MODELS AND MODEL TRAINING.

5050
03:22:09,830 --> 03:22:10,364
>> GREAT.

5051
03:22:10,364 --> 03:22:11,565
ONE MORE QUESTION.

5052
03:22:11,565 --> 03:22:14,835
FOR ME A.I. IS, YOU KNOW, IT'S

5053
03:22:14,835 --> 03:22:16,704
AKIN TO A CHILD, RIGHT?

5054
03:22:16,704 --> 03:22:18,572
YOU TRAIN IT, RIGHT?

5055
03:22:18,572 --> 03:22:20,941
AND IF YOU SIT A CHILD IN FRONT

5056
03:22:20,941 --> 03:22:24,044
OF A TV THAT PROJECTS ONE THING,

5057
03:22:24,044 --> 03:22:24,978
RIGHT, AND VALIDATE IT, THAT

5058
03:22:24,978 --> 03:22:26,413
CHILD IS GOING TO DO THOSE

5059
03:22:26,413 --> 03:22:26,914
THINGS LATER.

5060
03:22:26,914 --> 03:22:29,183
AND SO I THINK AS WE TALK ABOUT

5061
03:22:29,183 --> 03:22:30,918
DATA QUALITY, ANOTHER PART IS

5062
03:22:30,918 --> 03:22:31,385
REPRESENTATION.

5063
03:22:31,385 --> 03:22:33,120
I THINK IF YOU'RE BUILDING

5064
03:22:33,120 --> 03:22:34,221
MODELS AROUND PROSTATE CANCER

5065
03:22:34,221 --> 03:22:36,824
YOU WANT TO MAKE SURE THAT,

5066
03:22:36,824 --> 03:22:38,359
RIGHT, THERE'S A SIGNIFICANT

5067
03:22:38,359 --> 03:22:40,527
PROPORTION OF INDIVIDUALS ACROSS

5068
03:22:40,527 --> 03:22:41,428
VARIOUS RACIAL AND ETHNIC GROUPS

5069
03:22:41,428 --> 03:22:44,264
TO ENSURE THE MODEL WILL PERFORM

5070
03:22:44,264 --> 03:22:46,233
AS EFFECTIVELY, RIGHT, ACROSS

5071
03:22:46,233 --> 03:22:47,234
THESE POPULATIONS.

5072
03:22:47,234 --> 03:22:51,071
AND I'M NOT QUITE SURE HOW

5073
03:22:51,071 --> 03:22:52,406
YOU'RE INCORPORATING THIS INTO

5074
03:22:52,406 --> 03:22:54,241
HOW YOU'RE BUILDING AND TESTING

5075
03:22:54,241 --> 03:22:57,311
THESE MODELS AND VALIDATING THE 

5076
03:22:57,311 --> 03:23:01,014
>> SO, I'LL TAKE THAT A
LITTLE

5077
03:23:01,014 --> 03:23:03,851
BIT AND THEN I'LL LET DR. KIBBE

5078
03:23:03,851 --> 03:23:06,720
TALK ABOUT WHAT HE DOES.

5079
03:23:06,720 --> 03:23:08,889
ONE, WE NEED REPRESENTATIVE

5080
03:23:08,889 --> 03:23:10,057
SAMPLES, THAT KIND OF

5081
03:23:10,057 --> 03:23:11,525
REPRESENTATION IS EASY TO COUNT.

5082
03:23:11,525 --> 03:23:14,695
WHAT I APPRECIATE ABOUT USING

5083
03:23:14,695 --> 03:23:17,431
A.I. TO START TO DO FEATURE

5084
03:23:17,431 --> 03:23:18,932
DETECTION IN ASSOCIATION WITH

5085
03:23:18,932 --> 03:23:21,702
OUTCOMES IS THAT REMOVES A WHOLE

5086
03:23:21,702 --> 03:23:23,003
LOT OF BIAS THAT WE CURRENTLY

5087
03:23:23,003 --> 03:23:25,539
HAVE IN THE WAY WE THINK ABOUT

5088
03:23:25,539 --> 03:23:26,640
TREATING PATIENTS BECAUSE WE'RE

5089
03:23:26,640 --> 03:23:28,442
FOCUSED ON OUTCOMES.

5090
03:23:28,442 --> 03:23:31,011
WE'RE NOT FOCUSED IN THE MIDDLE.

5091
03:23:31,011 --> 03:23:34,715
SO, I THINK THAT'S A GOOD THING.

5092
03:23:34,715 --> 03:23:38,118
SO, I'D LOVE TO HEAR IF YOU ALL

5093
03:23:38,118 --> 03:23:39,319
AGREE THAT'S GOOD.

5094
03:23:39,319 --> 03:23:43,290
>> IF THERE ARE
DIFFERENCES IN

5095
03:23:43,290 --> 03:23:44,825
OUTCOMES YOU BEGIN TO WONDER IF

5096
03:23:44,825 --> 03:23:48,529
YOU CAN USE THAT AS A SURROGATE.

5097
03:23:48,529 --> 03:23:50,264
>> WELL, TRUE.

5098
03:23:50,264 --> 03:23:52,032
BUT IF YOU SEE PATIENTS THAT ARE

5099
03:23:52,032 --> 03:23:55,436
DOING WELL AND DOING POORLY IN

5100
03:23:55,436 --> 03:23:56,737
ALL GROUPS, YOU START TO SEE WHY

5101
03:23:56,737 --> 03:23:58,405
THEY ARE ALL DOING BETTER, ALL

5102
03:23:58,405 --> 03:24:01,008
DOING WORSE, THEN I THINK THAT

5103
03:24:01,008 --> 03:24:02,943
BECOMES A GREAT PROGNOSIS THAT

5104
03:24:02,943 --> 03:24:04,511
WE MOVES BIASES.

5105
03:24:04,511 --> 03:24:06,180
>> CAN I PIGGYBACK?

5106
03:24:06,180 --> 03:24:07,815
>> MAYBE THAT'S TOO
SIMPLISTIC.

5107
03:24:07,815 --> 03:24:12,753
>> WE HAVE KAREN AND
ANDREA.

5108
03:24:12,753 --> 03:24:17,324
>> I BUTTED IN.

5109
03:24:17,324 --> 03:24:18,859
I'M SORRY.

5110
03:24:18,859 --> 03:24:20,160
>> COOPERATION, IT'S EQUAL

5111
03:24:20,160 --> 03:24:21,161
ACCESS PATIENT POPULATION.

5112
03:24:21,161 --> 03:24:25,199
PATIENTS WHO ARE REFERRED TO

5113
03:24:25,199 --> 03:24:26,300
WALTER REED, AND ALSO

5114
03:24:26,300 --> 03:24:29,236
PROSPECTIVE CLINICAL TRIAL FOR

5115
03:24:29,236 --> 03:24:30,904
PROSTATE CANCER SO WE DIAGNOSE

5116
03:24:30,904 --> 03:24:35,042
PATIENTS, THEY ARE REFERRED TO

5117
03:24:35,042 --> 03:24:38,212
US, WE'RE STUDYING THOSE

5118
03:24:38,212 --> 03:24:40,080
IMMEDIATE AND MEDIUM AND

5119
03:24:40,080 --> 03:24:48,188
LONG-TERM  OUTCOMES UTILIZING

5120
03:24:48,188 --> 03:24:49,590
A.I. OUTCOMES.

5121
03:24:49,590 --> 03:24:50,357
>> COULD YOU TALK ABOUT

5122
03:24:50,357 --> 03:24:50,757
WORKFORCE?

5123
03:24:50,757 --> 03:24:53,327
WHICH IS GREAT, AND WE NEED TO

5124
03:24:53,327 --> 03:24:54,728
WELL A WORKFORCE BUT IT NEEDS TO

5125
03:24:54,728 --> 03:24:56,930
BE DIVERSE FOR MANY REASONS, BUT

5126
03:24:56,930 --> 03:24:58,999
I THINK THE MODEL, I'M GLAD YOU

5127
03:24:58,999 --> 03:25:00,434
CLARIFIED THE MODEL YOU'RE USING

5128
03:25:00,434 --> 03:25:01,969
PARTICULARLY PROSTATE CANCER BUT

5129
03:25:01,969 --> 03:25:03,270
ANY CANCER IS REPRESENTATIVE, DO

5130
03:25:03,270 --> 03:25:06,340
YOU KNOW WHAT PERCENT?

5131
03:25:06,340 --> 03:25:10,177
YOU'RE TALKING ABOUT 

5132
03:25:10,177 --> 03:25:10,844
PROGNOSTICATION.

5133
03:25:10,844 --> 03:25:11,979
WE KNOW AFRICAN AMERICAN

5134
03:25:11,979 --> 03:25:14,014
PATIENTS DO WORSE, IS IT A

5135
03:25:14,014 --> 03:25:15,382
TREATMENT EFFECT, A BIOLOGIC?

5136
03:25:15,382 --> 03:25:17,851
WE WON'T KNOW.

5137
03:25:17,851 --> 03:25:28,362
CAN YOU SHARE  PERCENTAGES OF

5138
03:25:29,830 --> 03:25:29,963
PRIMS.

5139
03:25:29,963 --> 03:25:31,632
>> 30 TO 35% IS THE
PROPORTION,

5140
03:25:31,632 --> 03:25:36,436
AND COMPARED TO THE NCI COHORT

5141
03:25:36,436 --> 03:25:39,373
WHICH IS AROUND 15%, BIASED

5142
03:25:39,373 --> 03:25:41,775
POPULATION, WE BELIEVE THAT'S

5143
03:25:41,775 --> 03:25:42,009
CORRECT.

5144
03:25:42,009 --> 03:25:42,876
>> THAT'S GREAT.

5145
03:25:42,876 --> 03:25:44,111
>> CLOSER TO REFLECTING

5146
03:25:44,111 --> 03:25:44,578
REPRESENTATION.

5147
03:25:44,578 --> 03:25:48,582
>> THAT'S GREAT BECAUSE
IT'S

5148
03:25:48,582 --> 03:25:48,949
OVERREPRESENTED.

5149
03:25:48,949 --> 03:25:50,784
ARE THERE WAYS YOU'RE THINKING

5150
03:25:50,784 --> 03:25:51,318
PROSPECTIVELY?

5151
03:25:51,318 --> 03:25:52,619
I JUST HAD A WONDERFUL TALK FROM

5152
03:25:52,619 --> 03:25:56,456
ONE OF OUR MEDICAL STUDENTS,

5153
03:25:56,456 --> 03:25:57,324
ACTUALLY AT VANDERBILT, WYATT

5154
03:25:57,324 --> 03:26:03,163
COLE TALKED ABOUT A.I. TO HELP

5155
03:26:03,163 --> 03:26:04,431
DEMOCRATIZE INFORMATION ON

5156
03:26:04,431 --> 03:26:06,300
PROSTATE CANCER TO EDUCATE

5157
03:26:06,300 --> 03:26:07,000
PATIENTS, MEN WITH PROSTATE

5158
03:26:07,000 --> 03:26:08,969
CANCER IN THE FAMILY BUT HE'S

5159
03:26:08,969 --> 03:26:12,773
MENTORED BY SOMEONE NOT IN THE

5160
03:26:12,773 --> 03:26:16,710
A.I. SPACE, A UROLOGIESIST BUT

5161
03:26:16,710 --> 03:26:17,811
MAY NOT THINGS ABOUT ISSUES

5162
03:26:17,811 --> 03:26:19,346
RELATED TO THE QUESTION.

5163
03:26:19,346 --> 03:26:22,816
THINK ABOUT TOOLS YOU'RE

5164
03:26:22,816 --> 03:26:28,655
THINKING ABOUT DEVELOPING SO AS

5165
03:26:28,655 --> 03:26:29,222
YOU ARE HELPING CREATE THE

5166
03:26:29,222 --> 03:26:32,192
LANDSCAPE THEY ARE NOT AN

5167
03:26:32,192 --> 03:26:32,960
AFTERTHOUGHT BUT PROSPECTIVELY

5168
03:26:32,960 --> 03:26:35,896
CONSIDERED THE WAY MODELS ARE

5169
03:26:35,896 --> 03:26:37,331
DEVELOPED, WHETHER MODELS ARE

5170
03:26:37,331 --> 03:26:41,635
RETRAINED, IT'S GOING TO BE

5171
03:26:41,635 --> 03:26:48,308
CRITICAL SO WE DON'T HAVE

5172
03:26:48,308 --> 03:26:49,610
GARBAGE IN, GARBAGE OUT.

5173
03:26:49,610 --> 03:26:53,180
>> ONE OF THE PARTNERSHIPS
IS

5174
03:26:53,180 --> 03:26:54,214
WITH THE NIH OFFICE OF DATA

5175
03:26:54,214 --> 03:26:55,315
SCIENCE STRATEGY COORDINATING AN

5176
03:26:55,315 --> 03:26:57,718
NIH EFFORT TO THINK ABOUT BIAS

5177
03:26:57,718 --> 03:26:58,285
INEQUITY IN A.I.

5178
03:26:58,285 --> 03:27:01,288
ONE OF THE RECENT FUNDING

5179
03:27:01,288 --> 03:27:04,324
OPPORTUNITIES FOR MULTI-MODAL

5180
03:27:04,324 --> 03:27:06,960
A.I. HAD A FORWARD GOAL OF

5181
03:27:06,960 --> 03:27:08,495
CO-DESIGN EFFORTS, AND ETHICAL

5182
03:27:08,495 --> 03:27:09,129
A.I.

5183
03:27:09,129 --> 03:27:11,331
WHAT WAS REALLY CRITICAL FOR

5184
03:27:11,331 --> 03:27:13,433
THIS PROGRAM WAS TO MAKE SURE

5185
03:27:13,433 --> 03:27:15,702
THAT THERE WAS A

5186
03:27:15,702 --> 03:27:16,803
MULTI-STAKEHOLDER GROUP AS PART

5187
03:27:16,803 --> 03:27:21,074
OF THE RESEARCH SO THAT THOSE

5188
03:27:21,074 --> 03:27:22,943
AFFECTED BY THE RESEARCH,

5189
03:27:22,943 --> 03:27:24,144
PHYSICIANS WHO ARE CONDUCTING --

5190
03:27:24,144 --> 03:27:26,980
TREATING THE PATIENTS AS WELL AS

5191
03:27:26,980 --> 03:27:28,281
RESEARCH, WE'RE ALL INVOLVED UP

5192
03:27:28,281 --> 03:27:31,485
FRONT IN THE MODEL DESIGN, SO I

5193
03:27:31,485 --> 03:27:35,756
THINK THAT'S A SENSE OF STARTING

5194
03:27:35,756 --> 03:27:38,258
TO REALIZE THE IMPORTANCE OF

5195
03:27:38,258 --> 03:27:39,559
HAVING CO-DESIGN EFFORTS UPFRONT

5196
03:27:39,559 --> 03:27:41,094
AND IMPLEMENTING THAT IN A

5197
03:27:41,094 --> 03:27:41,328
PROGRAM.

5198
03:27:41,328 --> 03:27:44,364
ALSO DID WANT TO MENTION THIS

5199
03:27:44,364 --> 03:27:46,066
ALSO IS AN ODS-LED PROGRAM, AIM

5200
03:27:46,066 --> 03:27:47,234
AHEAD PROGRAM YOU MAY HAVE HEARD

5201
03:27:47,234 --> 03:27:49,970
OF TO MAKE SURE THAT WE'RE

5202
03:27:49,970 --> 03:27:51,705
DEVELOPING A WORKFORCE NOT JUST

5203
03:27:51,705 --> 03:27:54,474
AT THE BIG CANCER CENTERS AND

5204
03:27:54,474 --> 03:27:56,977
BIG ACADEMIC CENTERS BUT AT MORE

5205
03:27:56,977 --> 03:27:58,612
BROADLY ACROSS ALL ACADEMIC

5206
03:27:58,612 --> 03:28:00,247
CENTERS SO THOSE CAPABILITIES

5207
03:28:00,247 --> 03:28:01,448
AND THAT LEARNING CAN BE MORE

5208
03:28:01,448 --> 03:28:08,455
DISTRIBUTED.

5209
03:28:08,455 --> 03:28:10,957
>> ANDREA AND FRED.

5210
03:28:10,957 --> 03:28:12,693
>> ALONG THE SAME THEME,
WHEN

5211
03:28:12,693 --> 03:28:13,727
AUTOMATIC HAND SANITIZERS CAME

5212
03:28:13,727 --> 03:28:15,796
OUT, HAD YOU TO PUT YOUR HAND

5213
03:28:15,796 --> 03:28:18,065
UNDERNEATH TO GET THE SANITIZER

5214
03:28:18,065 --> 03:28:20,267
TO COME OUT, THEY FORGOT TO

5215
03:28:20,267 --> 03:28:21,468
PROGRAM FOR BROWN SKIN.

5216
03:28:21,468 --> 03:28:23,236
WHEN I TURNED MY HAND OVER, IT

5217
03:28:23,236 --> 03:28:23,770
DIDN'T WORK.

5218
03:28:23,770 --> 03:28:25,072
THAT DOESN'T HAPPEN NOW BUT THIS

5219
03:28:25,072 --> 03:28:28,709
IS WHEN THEY FIRST STARTED TO

5220
03:28:28,709 --> 03:28:30,444
DEVELOP THEM.

5221
03:28:30,444 --> 03:28:32,412
ECHOING CONCERNS OF THE PREVIOUS

5222
03:28:32,412 --> 03:28:34,147
TWO QUESTIONS, WHEN IT COMES TO

5223
03:28:34,147 --> 03:28:35,816
SKIN CANCER, TALKING ABOUT

5224
03:28:35,816 --> 03:28:37,017
CANCER, HAVING THAT INFORMATION

5225
03:28:37,017 --> 03:28:39,653
IN THE DATABASE WHEN YOU'RE

5226
03:28:39,653 --> 03:28:41,054
DIAGNOSING SKIN CANCER AND

5227
03:28:41,054 --> 03:28:42,589
BENIGN DISEASE IS GOING TO BE

5228
03:28:42,589 --> 03:28:43,590
REALLY IMPORTANT TO HAVE

5229
03:28:43,590 --> 03:28:45,125
DIFFERENT SKIN COLORS IN THE

5230
03:28:45,125 --> 03:28:49,062
DATABASE OF A.I. OR ELSE IT

5231
03:28:49,062 --> 03:28:50,363
WON'T RECOGNIZE X SKIN COLOR,

5232
03:28:50,363 --> 03:28:52,132
WHEN YOU'RE TRYING TO GET THE

5233
03:28:52,132 --> 03:28:55,502
INFORMATION OUT FOR SOMETHING

5234
03:28:55,502 --> 03:28:57,037
LIKE  MELANOMA.

5235
03:28:57,037 --> 03:29:00,741
THAT WOULD EXTEND TO OTHER

5236
03:29:00,741 --> 03:29:01,441
DISEASES NOT NECESSARILY

5237
03:29:01,441 --> 03:29:03,443
PREDOMINANT IN AFRICAN AMERICANS

5238
03:29:03,443 --> 03:29:06,680
OR LATINOS, ET CETERA, SO

5239
03:29:06,680 --> 03:29:08,648
JUST -- WE KEEP ASKING THE SAME

5240
03:29:08,648 --> 03:29:10,250
QUESTION, BUT IT'S IMPORTANT TO

5241
03:29:10,250 --> 03:29:14,454
MAKE SURE AT THIS STAGE OF

5242
03:29:14,454 --> 03:29:18,258
THINGS WE'RE ACQUIRING DATA ON

5243
03:29:18,258 --> 03:29:20,227
ACROSS THE SPECTRUM OF

5244
03:29:20,227 --> 03:29:22,295
ETHNICITIES SO WHEN THESE

5245
03:29:22,295 --> 03:29:23,897
A.I. -- WHEN IT IS DEPLOYED IT

5246
03:29:23,897 --> 03:29:29,870
WILL BE ACCURATE.

5247
03:29:29,870 --> 03:29:30,704
>> I AGREE.

5248
03:29:30,704 --> 03:29:33,473
WHAT I APPRECIATE IS YOU MAKING

5249
03:29:33,473 --> 03:29:40,347
SURE WE DO THAT. 

5250
03:29:40,347 --> 03:29:42,749
SO, I THINK THAT'S REALLY -- I'M

5251
03:29:42,749 --> 03:29:44,751
NOT ALWAYS SURE HOW TO MAKE THAT

5252
03:29:44,751 --> 03:29:45,819
HAPPEN BUT HAVING YOU ASK THESE

5253
03:29:45,819 --> 03:29:47,888
QUESTIONS IS PART OF MAKING SURE

5254
03:29:47,888 --> 03:29:49,790
IT HAPPENS.

5255
03:29:49,790 --> 03:29:57,831
>> WE'D  LOVE TO HELP.

5256
03:29:57,831 --> 03:29:58,532
>> THERE'S A CONCEPT,
FEDERATED

5257
03:29:58,532 --> 03:30:01,368
LEARNING, THE MAIN ISSUE OR THE

5258
03:30:01,368 --> 03:30:05,205
CONCERN IS SHARING DATA, WITH

5259
03:30:05,205 --> 03:30:08,608
FEDERATED LEARNING YOU CAN MOVE

5260
03:30:08,608 --> 03:30:12,012
YOUR MODEL, YOUR DATA CAN STAY.

5261
03:30:12,012 --> 03:30:14,481
WITHOUT MOVING THE AMERICAN

5262
03:30:14,481 --> 03:30:16,249
DATA, WITH THE SLIDE I SHOWED,

5263
03:30:16,249 --> 03:30:18,351
WE WILL FURTHER TRAIN THE MODEL

5264
03:30:18,351 --> 03:30:20,453
IN EUROPE AND THEN WE HOPE TO

5265
03:30:20,453 --> 03:30:22,789
PUT MORE DIVERSITY IN IT.

5266
03:30:22,789 --> 03:30:25,492
WE'LL TAKE THE DATA TO AFRICA

5267
03:30:25,492 --> 03:30:36,002
AND FURTHER TRAIN, WE'LL HAVE

5268
03:30:41,074 --> 03:30:42,309
MOST IDEAL MODEL.

5269
03:30:42,309 --> 03:30:52,853
WE HAVE CAPABILITY OF DEVELOPING

5270
03:30:55,488 --> 03:30:59,159
DIVERSE MODELS.

5271
03:30:59,159 --> 03:31:00,160
>> QUICKLY, I WONDER,
WARREN,

5272
03:31:00,160 --> 03:31:03,964
ONE AREA WE HAVE A GREAT NEED IS

5273
03:31:03,964 --> 03:31:06,499
MORE LONGITUDINAL DATA, AND I

5274
03:31:06,499 --> 03:31:08,702
WAS WONDERING, I MEAN,

5275
03:31:08,702 --> 03:31:11,304
ESSENTIALLY TO DEVELOP THESE

5276
03:31:11,304 --> 03:31:13,273
MODELS ALONG LONGITUDINAL LINES,

5277
03:31:13,273 --> 03:31:15,275
SO IS THERE -- DO YOU HAVE PLANS

5278
03:31:15,275 --> 03:31:17,878
FOR THAT IN TERMS OF SOME OF THE

5279
03:31:17,878 --> 03:31:20,413
MECHANISMS WE MIGHT USE AT NCI

5280
03:31:20,413 --> 03:31:25,118
OR CLINICAL CENTER TO ADDRESS

5281
03:31:25,118 --> 03:31:25,652
THIS?

5282
03:31:25,652 --> 03:31:25,919
>> SURE.

5283
03:31:25,919 --> 03:31:26,953
THANK YOU FOR THE QUESTION.

5284
03:31:26,953 --> 03:31:28,388
I THINK THAT'S ONE OF THE HOPES

5285
03:31:28,388 --> 03:31:31,791
WITH WHAT WE'RE DOING WITH CCDI

5286
03:31:31,791 --> 03:31:33,627
AS WE START TO BUILD THAT

5287
03:31:33,627 --> 03:31:34,961
LONGITUDINAL VIEW OF PATIENTS

5288
03:31:34,961 --> 03:31:36,363
AND UNDERSTAND HOW TO CAPTURE

5289
03:31:36,363 --> 03:31:39,099
DATA AND ANALYZE IT.

5290
03:31:39,099 --> 03:31:41,301
WE'RE STILL -- WE'RE NOT AS FAR

5291
03:31:41,301 --> 03:31:44,037
ALONG AS I WOULD LIKE WITH CCDI

5292
03:31:44,037 --> 03:31:45,238
BUT THAT'S ONE OF THE

5293
03:31:45,238 --> 03:31:45,572
OPPORTUNITIES.

5294
03:31:45,572 --> 03:31:46,873
IF WE CAN GET IT RIGHT FOR

5295
03:31:46,873 --> 03:31:48,842
CHILDREN, WE CAN GET IT RIGHT

5296
03:31:48,842 --> 03:31:51,578
FOR YOUNG ADULTS, THEN WE CAN

5297
03:31:51,578 --> 03:31:53,246
GET IT RIGHT FOR EVERYONE.

5298
03:31:53,246 --> 03:31:54,547
SO I AGREE, UNDERSTANDING THAT

5299
03:31:54,547 --> 03:31:59,019
TRAJECTORY OF DISEASE IS JUST SO

5300
03:31:59,019 --> 03:31:59,352
IMPORTANT.

5301
03:31:59,352 --> 03:32:03,189
>> SO, JULI, WAS YOUR HAND
UP?

5302
03:32:03,189 --> 03:32:04,491
YOU AND THEN NELO.

5303
03:32:04,491 --> 03:32:06,793
>> I KNOW THAT AT LEAST IN
THE

5304
03:32:06,793 --> 03:32:09,329
MOMENT IN OTHER SECTORS THE COST

5305
03:32:09,329 --> 03:32:10,964
OF BUYING CHIPS AND

5306
03:32:10,964 --> 03:32:11,698
COMPUTATIONAL CAPABILITIES IS

5307
03:32:11,698 --> 03:32:12,599
SOMETHING THAT'S VERY TOP OF

5308
03:32:12,599 --> 03:32:12,832
MIND.

5309
03:32:12,832 --> 03:32:15,001
I KNOW AS WE LOOK AT THE

5310
03:32:15,001 --> 03:32:16,536
INFLATION ADJUSTED BUDGET THAT

5311
03:32:16,536 --> 03:32:17,537
WAS WELL PRESENTED EARLIER

5312
03:32:17,537 --> 03:32:19,606
TODAY, ONE OF THE AREAS I'M

5313
03:32:19,606 --> 03:32:22,342
WONDERING ABOUT IS HOW IS

5314
03:32:22,342 --> 03:32:24,978
INFRASTRUCTURE BEING PAID FOR

5315
03:32:24,978 --> 03:32:25,278
CURRENTLY?

5316
03:32:25,278 --> 03:32:26,346
IS THAT SOMETHING WE NEED TO

5317
03:32:26,346 --> 03:32:29,215
THINK ABOUT IN THE NCI BUDGET?

5318
03:32:29,215 --> 03:32:31,084
IS THAT AN NIH BUDGET LINE OR

5319
03:32:31,084 --> 03:32:32,419
ARE ALL THE CENTERS POOLING IN

5320
03:32:32,419 --> 03:32:35,922
TO GIVE YOU RESOURCES TO ACQUIRE

5321
03:32:35,922 --> 03:32:38,058
CAPABILITIES THAT YOU NEED?

5322
03:32:38,058 --> 03:32:40,493
CURIOUS HOW WE SHOULD BE

5323
03:32:40,493 --> 03:32:41,428
THINKING ABOUT BUDGETING AS THE

5324
03:32:41,428 --> 03:32:45,732
RESULT OF THE NEED TO BUY CHIPS,

5325
03:32:45,732 --> 03:32:48,368
COMPUTE, AND INFRASTRUCTURE.

5326
03:32:48,368 --> 03:32:49,035
>> YOU'RE ASKING AN
INSIGHTFUL

5327
03:32:49,035 --> 03:32:50,570
QUESTION BECAUSE YOU CAN SPEND

5328
03:32:50,570 --> 03:32:52,872
ANY AMOUNT OF MONEY IN BUILDING

5329
03:32:52,872 --> 03:32:53,540
A.I. INFRASTRUCTURE.

5330
03:32:53,540 --> 03:32:55,842
AGAIN, THAT'S AN OPPORTUNITY FOR

5331
03:32:55,842 --> 03:32:58,778
US TO REALLY PARTNER WITH

5332
03:32:58,778 --> 03:32:59,045
INDUSTRY.

5333
03:32:59,045 --> 03:33:03,249
WE HAVE I THINK A PRETTY BIG

5334
03:33:03,249 --> 03:33:04,351
OPPORTUNITY TO WORK WITH, YOU

5335
03:33:04,351 --> 03:33:07,454
KNOW, NAME YOUR FAVORITE TECH

5336
03:33:07,454 --> 03:33:09,089
COMPANY, TO GET THEM EMBEDDED,

5337
03:33:09,089 --> 03:33:11,358
HAVE THEM WORK ON REALLY

5338
03:33:11,358 --> 03:33:13,560
IMPORTANT PROBLEMS FOR US.

5339
03:33:13,560 --> 03:33:15,428
BUT TO YOUR QUESTION, YOU KNOW,

5340
03:33:15,428 --> 03:33:16,963
WE DON'T HAVE AS MUCH

5341
03:33:16,963 --> 03:33:20,367
INFRASTRUCTURE FOR DOING A.I.

5342
03:33:20,367 --> 03:33:22,869
LEARN ITSELF AND TRAINING AS WE

5343
03:33:22,869 --> 03:33:25,238
PROBABLY NEED BUT I THINK WE

5344
03:33:25,238 --> 03:33:28,408
HAVE ENOUGH.

5345
03:33:28,408 --> 03:33:28,675
>> YEAH.

5346
03:33:28,675 --> 03:33:32,345
SO WE HAVE VERY STRONG HPC

5347
03:33:32,345 --> 03:33:36,416
CLUSTER, BIOWULF, AT NIH, OPEN

5348
03:33:36,416 --> 03:33:38,385
TO ALMOST EVERY RESEARCHER WITH

5349
03:33:38,385 --> 03:33:39,352
SYMBOLIC COST, AND IN ADDITION

5350
03:33:39,352 --> 03:33:44,524
TO THAT THE LAB HAS THEIR OWN

5351
03:33:44,524 --> 03:33:45,825
HIGH POWERED COMPUTATIONAL

5352
03:33:45,825 --> 03:33:46,159
COMPUTERS.

5353
03:33:46,159 --> 03:33:47,360
TO DEVELOP MODELS, YES, YOU NEED

5354
03:33:47,360 --> 03:33:49,095
THAT TYPE OF INFRASTRUCTURE BUT

5355
03:33:49,095 --> 03:33:50,263
TO RUN THESE MODELS YOU WON'T

5356
03:33:50,263 --> 03:33:53,933
NEED THAT.

5357
03:33:53,933 --> 03:33:55,435
>> ONE LAST QUESTION FROM
NELO

5358
03:33:55,435 --> 03:33:57,237
BECAUSE WE NEED TO MOVE ON.

5359
03:33:57,237 --> 03:33:58,538
>> I'LL BE QUICK.

5360
03:33:58,538 --> 03:34:00,073
I'M A CLINICAL RESEARCHERS.

5361
03:34:00,073 --> 03:34:01,941
MANY YEARS AGO I HAD THE

5362
03:34:01,941 --> 03:34:04,344
OPPORTUNITY TO PARTICIPATE IN A

5363
03:34:04,344 --> 03:34:08,081
WORKSHOP THAT ASCO PUT ON, AT

5364
03:34:08,081 --> 03:34:15,422
VEIL, WE SPENT A WEEK, NETWORK,

5365
03:34:15,422 --> 03:34:17,390
LEARNED SKILLS, POPULATED FROM

5366
03:34:17,390 --> 03:34:18,491
THE IVORY TOWERS.

5367
03:34:18,491 --> 03:34:20,360
THIS YEAR THE SAME WORKSHOP IN

5368
03:34:20,360 --> 03:34:22,262
EUROPE WAS A VERY DIFFERENT

5369
03:34:22,262 --> 03:34:22,762
EXPERIENCE.

5370
03:34:22,762 --> 03:34:24,731
AND SO SATISFYING BECAUSE IT WAS

5371
03:34:24,731 --> 03:34:26,299
NOT JUST IVORY TOWERS IN EUROPE

5372
03:34:26,299 --> 03:34:32,972
BUT ALSO, YOU KNOW, POLISH

5373
03:34:32,972 --> 03:34:34,040
INVESTIGATORS AND OTHERS FROM

5374
03:34:34,040 --> 03:34:35,141
EASTERN EUROPE, GAVE THEM THE

5375
03:34:35,141 --> 03:34:36,576
OPPORTUNITY TO LEARN AND

5376
03:34:36,576 --> 03:34:37,677
NETWORK.

5377
03:34:37,677 --> 03:34:39,813
THIS AREA WOULD BE VERY RIPE FOR

5378
03:34:39,813 --> 03:34:44,017
THAT KIND OF A WORKSHOP, YOU

5379
03:34:44,017 --> 03:34:45,351
COULD HAVE SENIOR LEADERS TEACH

5380
03:34:45,351 --> 03:34:46,553
WHERE PEOPLE COULD NETWORK AND

5381
03:34:46,553 --> 03:34:48,088
GO FOR A FEW DAYS AND REALLY

5382
03:34:48,088 --> 03:34:51,925
LEARN WHAT IS A.I. AND HOW CAN

5383
03:34:51,925 --> 03:34:53,359
WE APPLY IT.

5384
03:34:53,359 --> 03:34:54,794
>> GREAT COMMENT.

5385
03:34:54,794 --> 03:34:56,329
>> I'LL JUST SAY THAT'S
PART OF

5386
03:34:56,329 --> 03:34:58,965
WHAT AIM HEAD IS DOING,

5387
03:34:58,965 --> 03:35:00,033
PARTNERING WITH AIM AHEAD, I

5388
03:35:00,033 --> 03:35:01,701
THINK WE CAN DO SOME OF THAT.

5389
03:35:01,701 --> 03:35:04,437
BUT WE NEED TO ALSO ADD MORE OF

5390
03:35:04,437 --> 03:35:07,640
A CANCER FLAVOR TO AIM AHEAD.

5391
03:35:07,640 --> 03:35:11,878
>> THANK YOU ALL SO MUCH. 

5392
03:35:11,878 --> 03:35:12,412
FANTASTIC PRESENTATION.

5393
03:35:12,412 --> 03:35:15,682
[APPLAUSE] 

5394
03:35:15,682 --> 03:35:17,117
>> FINAL PRESENTATION
TODAY IS

5395
03:35:17,117 --> 03:35:21,287
AN UPDATE ON THE NCI COMMUNITY

5396
03:35:21,287 --> 03:35:22,422
ONCOLOGY RESEARCH PROGRAM,

5397
03:35:22,422 --> 03:35:26,326
NCORP, AND NATIONAL CLINICAL

5398
03:35:26,326 --> 03:35:27,193
TRIALS NETWORK, NCTN.

5399
03:35:27,193 --> 03:35:28,495
PRESENTATION WILL BE BROUGHT TO

5400
03:35:28,495 --> 03:35:30,830
YOUS BY DR. PHIL CASTLE,

5401
03:35:30,830 --> 03:35:32,665
DIRECTOR OF DIVISION OF CANCER

5402
03:35:32,665 --> 03:35:34,601
PREVENTION AND JIM DOROSHOW,

5403
03:35:34,601 --> 03:35:35,568
DIRECTOR FOR DIVISION OF CANCER

5404
03:35:35,568 --> 03:35:40,974
TREATMENT DIAGNOSIS.

5405
03:35:40,974 --> 03:35:41,841
>> THANK YOU, JOHN.

5406
03:35:41,841 --> 03:35:44,611
ON BEHALF OF THE NCI AND

5407
03:35:44,611 --> 03:35:46,146
DIVISION OF CANCER PREVENTION,

5408
03:35:46,146 --> 03:35:48,014
I'M PLEASED TO PRESENT THE

5409
03:35:48,014 --> 03:35:50,350
UPDATE ON NCI COMMUNITY ONCOLOGY

5410
03:35:50,350 --> 03:35:50,950
RESEARCH PROGRAM.

5411
03:35:50,950 --> 03:35:53,153
THIS IS REALLY A FLAGSHIP

5412
03:35:53,153 --> 03:35:54,587
PROGRAM FOR THE INSTITUTE AND

5413
03:35:54,587 --> 03:35:56,890
YOU'LL SEE WHY HERE, WHY IT'S SO

5414
03:35:56,890 --> 03:36:02,395
CRITICAL TO THE FUNCTION OF THE

5415
03:36:02,395 --> 03:36:03,763
NCI.

5416
03:36:03,763 --> 03:36:05,198
SO, NCORP OVERVIEW, IT'S A

5417
03:36:05,198 --> 03:36:07,167
MERGING OF TWO COMMUNITY

5418
03:36:07,167 --> 03:36:09,669
PROGRAMS THAT EXISTED

5419
03:36:09,669 --> 03:36:10,670
PREVIOUSLY.

5420
03:36:10,670 --> 03:36:16,142
ONE IS C COP, STARTED IN 1983,

5421
03:36:16,142 --> 03:36:18,211
SOME OF MY STAFF WERE HERE TO

5422
03:36:18,211 --> 03:36:20,547
START THAT, AND THE NCI

5423
03:36:20,547 --> 03:36:22,182
COMMUNITY CANCERS CENTER GRANT

5424
03:36:22,182 --> 03:36:23,483
IN 2017, WE MERGED THOSE WITH

5425
03:36:23,483 --> 03:36:25,451
THE FOLLOWING GOALS.

5426
03:36:25,451 --> 03:36:28,254
ONE TO ENROLL PATIENTS IN

5427
03:36:28,254 --> 03:36:28,955
TREATMENT ADVANCED IMAGING

5428
03:36:28,955 --> 03:36:31,925
CLINICAL TRIALS THAT ARE

5429
03:36:31,925 --> 03:36:33,359
DEVELOPED THROUGH THE NCTN, BY

5430
03:36:33,359 --> 03:36:36,095
THE DIVISION OF CANCER TREATMENT

5431
03:36:36,095 --> 03:36:36,863
AND DIAGNOSIS.

5432
03:36:36,863 --> 03:36:39,599
AND THEN SUPPORT INCLUSION OF

5433
03:36:39,599 --> 03:36:42,635
HEALTH-RELATED QUALITY OF LIFE

5434
03:36:42,635 --> 03:36:44,370
CORRELATIVE STUDIES IN NCTN,

5435
03:36:44,370 --> 03:36:45,471
TREATMENT TRIALS, AND AGAIN I

5436
03:36:45,471 --> 03:36:47,807
WANT TO EMPHASIZE WHY THIS IS SO

5437
03:36:47,807 --> 03:36:50,210
IMPORTANT, IN 2022 WE HAD 18

5438
03:36:50,210 --> 03:36:51,311
MILLION CANCER SURVIVORS, WHICH

5439
03:36:51,311 --> 03:36:56,115
WAS MORE THAN 5% OF THE U.S.

5440
03:36:56,115 --> 03:36:56,549
POPULATION.

5441
03:36:56,549 --> 03:37:00,320
BY 2040 WE EXPECT THERE WILL BE

5442
03:37:00,320 --> 03:37:02,822
26 MILLION CANCER SURVIVORS, 7%

5443
03:37:02,822 --> 03:37:04,123
OF THE POPULATION.

5444
03:37:04,123 --> 03:37:05,792
1 IN 14 PEOPLE WILL BE WALKING

5445
03:37:05,792 --> 03:37:07,293
AROUND AS A CANCER SURVIVOR.

5446
03:37:07,293 --> 03:37:09,128
WE HAVE TO THINK MORE ABOUT NOT

5447
03:37:09,128 --> 03:37:10,496
JUST TAKING CARE OF THE TUMOR

5448
03:37:10,496 --> 03:37:14,300
BUT TAKING CARE OF THE WHOLE

5449
03:37:14,300 --> 03:37:14,534
PERSON.

5450
03:37:14,534 --> 03:37:16,169
ENGAGE IN LARGE AND DIVERSE

5451
03:37:16,169 --> 03:37:17,036
PATIENT POPULATIONS, RECEIVING

5452
03:37:17,036 --> 03:37:20,340
CARE IN A VARIETY OF COMMUNITY

5453
03:37:20,340 --> 03:37:22,275
ONCOLOGY SETTINGS, STUDIES ON

5454
03:37:22,275 --> 03:37:23,276
CANCER CONTROL, PREVENTION, CARE

5455
03:37:23,276 --> 03:37:23,643
DELIVERY.

5456
03:37:23,643 --> 03:37:25,578
AND TO GENERATE A BROADLY

5457
03:37:25,578 --> 03:37:27,213
APPLICABLE EVIDENCE BASE THAT

5458
03:37:27,213 --> 03:37:28,982
CONTRIBUTES TO IMPROVED PATIENT

5459
03:37:28,982 --> 03:37:32,385
OUTCOMES AND REDUCTION IN CANCER

5460
03:37:32,385 --> 03:37:32,685
DISPARITIES.

5461
03:37:32,685 --> 03:37:34,053
BEFORE I GET INTO THE MEAT OF

5462
03:37:34,053 --> 03:37:39,359
THIS I WANT TO TAKE A MOMENT

5463
03:37:39,359 --> 03:37:47,567
HERE TO HONOR THE LATE WARDA

5464
03:37:47,567 --> 03:37:49,569
MCCASKILL-STEVENS WHO MADE

5465
03:37:49,569 --> 03:37:52,705
SEMINAL CONTRIBUTIONS, WE HOPE

5466
03:37:52,705 --> 03:37:55,875
HER LEGACY WILL GROW THROUGH THE

5467
03:37:55,875 --> 03:38:02,015
COMMUNITY SUPPORTED BY THE K12

5468
03:38:02,015 --> 03:38:04,751
PROGRAM NAMED AFTER HER, AN

5469
03:38:04,751 --> 03:38:05,685
EXCITING PROGRAM MONICA BROUGHT

5470
03:38:05,685 --> 03:38:07,153
IN A YEAR AGO.

5471
03:38:07,153 --> 03:38:12,058
FIRST I WANT TO ACKNOWLEDGE

5472
03:38:12,058 --> 03:38:13,393
BRANDY HECKEN STODDARD, WHO

5473
03:38:13,393 --> 03:38:16,129
STEPPED IN TO THE NCORP AND HAS

5474
03:38:16,129 --> 03:38:21,601
DONE AN  AMAZING JOB.

5475
03:38:21,601 --> 03:38:24,237
THE NCORP IS SEVEN RESEARCH

5476
03:38:24,237 --> 03:38:27,073
BASES INCLUDING FIVE COOPERATIVE

5477
03:38:27,073 --> 03:38:29,909
GROUPS, WHO CANCER CENTER-LED

5478
03:38:29,909 --> 03:38:32,011
RESEARCH BASES. 

5479
03:38:32,011 --> 03:38:35,281
THERE'S 32 COMMUNITY SITES, 14

5480
03:38:35,281 --> 03:38:37,016
UNDERSERVED MINORITY SITES, AND

5481
03:38:37,016 --> 03:38:40,953
TOTAL, AND I'LL EXPLAIN IN THE

5482
03:38:40,953 --> 03:38:42,722
NEXT SLIDE, THERE ARE MORE THAN

5483
03:38:42,722 --> 03:38:45,992
A THOUSAND CLINICAL SITES IN

5484
03:38:45,992 --> 03:38:47,093
NCORP THROUGH AFFILIATES.

5485
03:38:47,093 --> 03:38:50,596
50% OF THESE HUBS SHOWN HERE IN

5486
03:38:50,596 --> 03:38:53,900
THE DOTS AND THE TRIANGLES HAVE

5487
03:38:53,900 --> 03:38:55,501
AFFILIATE SITES THAT ESSENTIALLY

5488
03:38:55,501 --> 03:39:00,039
CREATE A NATIONAL NETWORK.

5489
03:39:00,039 --> 03:39:01,574
HERE IT'S ILLUSTRATED, I HOPE

5490
03:39:01,574 --> 03:39:02,008
THIS WORKS.

5491
03:39:02,008 --> 03:39:02,875
YES, IT DOES.

5492
03:39:02,875 --> 03:39:05,712
YOU CAN SEE THE NUMBER OF SITES

5493
03:39:05,712 --> 03:39:07,380
PER STATE GOING FROM ONE TO

5494
03:39:07,380 --> 03:39:09,782
NINE, TO 15 ABOVE, WE HAVE A FEW

5495
03:39:09,782 --> 03:39:11,851
HOLES HERE THAT WE NEED TO THINK

5496
03:39:11,851 --> 03:39:12,418
ABOUT FILLING.

5497
03:39:12,418 --> 03:39:15,254
AND SOME OF THESE STATES ARE

5498
03:39:15,254 --> 03:39:16,155
LESS REPRESENTED THAN OTHERS.

5499
03:39:16,155 --> 03:39:18,558
BUT THIS IS HOW WE GET TO THOSE

5500
03:39:18,558 --> 03:39:19,759
THOUSAND SITES.

5501
03:39:19,759 --> 03:39:21,694
LET'S TAKE THE MONTANA ONE HERE,

5502
03:39:21,694 --> 03:39:24,864
WHICH IS THE MONTANA NCORP, WITH

5503
03:39:24,864 --> 03:39:27,066
ALL THESE AFFILIATES IN A SPOKE

5504
03:39:27,066 --> 03:39:28,935
AND HUB, NOT PERFECT BUT YOU GET

5505
03:39:28,935 --> 03:39:29,702
THE IDEA.

5506
03:39:29,702 --> 03:39:32,872
AND THEN HERE'S ANOTHER EXAMPLE.

5507
03:39:32,872 --> 03:39:35,608
THIS IS BAPTIST HEALTH NCORP

5508
03:39:35,608 --> 03:39:36,709
MINORITY AND UNDERSERVED.

5509
03:39:36,709 --> 03:39:39,879
AND YOU CAN SEE HERE AGAIN THAT

5510
03:39:39,879 --> 03:39:41,180
IT'S A NETWORK OF CLINICAL

5511
03:39:41,180 --> 03:39:41,481
SITES.

5512
03:39:41,481 --> 03:39:43,950
THAT'S HOW WE GET TO OVER A

5513
03:39:43,950 --> 03:39:46,018
THOUSAND CLINICAL SITES ACROSS

5514
03:39:46,018 --> 03:39:47,653
THE U.S.

5515
03:39:47,653 --> 03:39:48,654
THIS IS THE BREAKDOWN.

5516
03:39:48,654 --> 03:39:50,623
I'M NOT GOING TO READ THROUGH

5517
03:39:50,623 --> 03:39:50,957
ALL THIS.

5518
03:39:50,957 --> 03:39:55,762
WE HAVE A VARIETY OF PEOPLE

5519
03:39:55,762 --> 03:39:59,031
INVOLVED, ALMOST MORE THAN 4,000

5520
03:39:59,031 --> 03:40:00,466
PHYSICIAN-SCIENTISTS, ALMOST

5521
03:40:00,466 --> 03:40:05,705
5,000 RESEARCH STAFF, DIFFERENT

5522
03:40:05,705 --> 03:40:08,775
HEALTHCARE SYSTEMS, STAND-ALONE

5523
03:40:08,775 --> 03:40:12,145
INSTITUTIONS, 383 COMMUNITY

5524
03:40:12,145 --> 03:40:12,712
AFFILIATES, 98 MINORITY

5525
03:40:12,712 --> 03:40:13,846
UNDERSERVED AFFILIATES, 441

5526
03:40:13,846 --> 03:40:15,348
COMMUNITY SUBAFFILIATES AND SO

5527
03:40:15,348 --> 03:40:17,617
FORTH, ALL SORTS OF CLINICAL

5528
03:40:17,617 --> 03:40:18,050
SITES.

5529
03:40:18,050 --> 03:40:19,585
YOU'LL HAVE ALL THIS

5530
03:40:19,585 --> 03:40:19,886
INFORMATION.

5531
03:40:19,886 --> 03:40:21,587
I DON'T WANT TO DWELL ON IT BUT

5532
03:40:21,587 --> 03:40:23,322
TO GIVE A FLAVOR OF THE

5533
03:40:23,322 --> 03:40:25,391
DIVERSITY NOT JUST OF THE PEOPLE

5534
03:40:25,391 --> 03:40:27,527
WE RECRUIT BUT PEOPLE INVOLVED

5535
03:40:27,527 --> 03:40:28,995
IN NCORP WITH BOOTS ON THE

5536
03:40:28,995 --> 03:40:29,562
GROUND.

5537
03:40:29,562 --> 03:40:30,863
NOT THE CRITICAL PIECE OF THE

5538
03:40:30,863 --> 03:40:33,266
NCORP, WHICH IS WE'RE WORKING

5539
03:40:33,266 --> 03:40:34,467
WITH COMMUNITY ONCOLOGISTS, SO

5540
03:40:34,467 --> 03:40:36,669
WHATEVER WE DO WITH THEM THEN

5541
03:40:36,669 --> 03:40:38,538
CAN GO INTO ROUTINE PRACTICE,

5542
03:40:38,538 --> 03:40:40,506
WE'RE NOT JUST TESTING HOW TO DO

5543
03:40:40,506 --> 03:40:44,010
BETTER CARE BUT THEN HOPEFULLY

5544
03:40:44,010 --> 03:40:47,947
IMPLEMENTING BETTER CARE THROUGH

5545
03:40:47,947 --> 03:40:49,449
THEIR ENGAGEMENT.

5546
03:40:49,449 --> 03:40:50,883
THIS IS AN IMPORTANT

5547
03:40:50,883 --> 03:40:52,418
RELATIONSHIP, JIM WILL TALK

5548
03:40:52,418 --> 03:40:56,255
ABOUT THIS A BIT MORE.

5549
03:40:56,255 --> 03:40:59,192
WE WORK CLOSELY WITH NCTN.

5550
03:40:59,192 --> 03:41:01,194
WE USE A LOT OF THEIR

5551
03:41:01,194 --> 03:41:07,667
INFRASTRUCTURE  LIKE THE CIRB AD

5552
03:41:07,667 --> 03:41:08,634
OTHER INFRASTRUCTURE ESTABLISHED

5553
03:41:08,634 --> 03:41:11,337
BY MEGAN AND JIM.

5554
03:41:11,337 --> 03:41:13,005
WE SPLIT THIS UP, NCTN FOCUSES

5555
03:41:13,005 --> 03:41:15,508
ON LATE PHASE TREATMENT TRIALS,

5556
03:41:15,508 --> 03:41:17,043
PRIMARY ADVANCED IMAGING.

5557
03:41:17,043 --> 03:41:19,679
ON THE CANCER CONTROL QUALITY OF

5558
03:41:19,679 --> 03:41:20,680
LIFE PREVENTION SCREENING

5559
03:41:20,680 --> 03:41:21,647
TRIALS, CANCER CARE DELIVERY, WE

5560
03:41:21,647 --> 03:41:24,684
DO A LOT OF THIS WORK WITH OUR

5561
03:41:24,684 --> 03:41:26,452
GOOD COLLEAGUES IN DCCPS WHO

5562
03:41:26,452 --> 03:41:27,987
HEAD UP THE CANCER CARE

5563
03:41:27,987 --> 03:41:28,454
DELIVERY.

5564
03:41:28,454 --> 03:41:30,957
HERE IS THE OVERLAP HERE.

5565
03:41:30,957 --> 03:41:32,492
WE CONTRIBUTE ALMOST 30% AS

5566
03:41:32,492 --> 03:41:34,861
YOU'LL SEE IN THE FOLLOWING

5567
03:41:34,861 --> 03:41:37,530
SLIDE TO THE TREATMENT TRIALS AT

5568
03:41:37,530 --> 03:41:41,133
THE NCTN, OR THE NCORP, WE, THE

5569
03:41:41,133 --> 03:41:43,336
NCORP CONTRIBUTES ALMOST 30%.

5570
03:41:43,336 --> 03:41:45,404
AND HERE'S THE NUMBERS OVER THE

5571
03:41:45,404 --> 03:41:49,108
LAST FIVE YEARS.

5572
03:41:49,108 --> 03:41:51,410
THIS IS JUST TO DEMARC WHERE

5573
03:41:51,410 --> 03:41:53,980
COVID IS AND I PUT AN ASTERISK

5574
03:41:53,980 --> 03:41:55,882
HERE BECAUSE THIS IS NCORP

5575
03:41:55,882 --> 03:41:57,984
FISCAL YEARS, WHICH STARTS LATE

5576
03:41:57,984 --> 03:42:01,053
IN THE CALENDAR YEAR.

5577
03:42:01,053 --> 03:42:11,497
SO, OUR CALENDAR FOR NCORP

5578
03:42:13,232 --> 03:42:14,066
STARTS IN AUGUST, SO 2019

5579
03:42:14,066 --> 03:42:15,501
STARTED IN AUGUST.

5580
03:42:15,501 --> 03:42:18,204
I HOPE I'VE NOW CONFUSED YOU

5581
03:42:18,204 --> 03:42:19,739
COMPLETELY.

5582
03:42:19,739 --> 03:42:21,807
YOU CAN SEE NUMBERS FROM 2019 TO

5583
03:42:21,807 --> 03:42:24,410
2023, ALL SORTS OF DIFFERENT

5584
03:42:24,410 --> 03:42:26,412
CATEGORIES, CANCER PREVENTION

5585
03:42:26,412 --> 03:42:28,915
AND CONTROL FROM NON-NCORP

5586
03:42:28,915 --> 03:42:30,783
SITES, CPC CANCER PREVENTION AND

5587
03:42:30,783 --> 03:42:34,420
CONTROL FOR NCORP, TREATMENT

5588
03:42:34,420 --> 03:42:35,821
TRIALS HERE, AND MINORITY

5589
03:42:35,821 --> 03:42:37,356
CONTRIBUTIONS TO TREATMENT

5590
03:42:37,356 --> 03:42:37,590
TRIALS.

5591
03:42:37,590 --> 03:42:39,992
SO MORE THAN 3,000, ALMOST 35 --

5592
03:42:39,992 --> 03:42:42,862
MORE THAN 3500 COME FROM

5593
03:42:42,862 --> 03:42:44,597
NCORP-RELATED GROUPS

5594
03:42:44,597 --> 03:42:48,968
CONTRIBUTING TO THE TREATMENT

5595
03:42:48,968 --> 03:42:49,402
TRIALS.

5596
03:42:49,402 --> 03:42:55,641
THIS IS A BREAKDOWN OF SOME OF

5597
03:42:55,641 --> 03:42:57,043
THE ACTIVITIES WITHIN THESE

5598
03:42:57,043 --> 03:42:58,044
DIFFERENT GROUPS.

5599
03:42:58,044 --> 03:42:59,679
AND THE NUMBER HIGHLIGHTED HERE

5600
03:42:59,679 --> 03:43:02,648
IN YELLOW IS QUALITY OF LIFE

5601
03:43:02,648 --> 03:43:06,452
NUMBERS SO WE CONTRIBUTE IN SOME

5602
03:43:06,452 --> 03:43:07,587
CASES MORE THAN 3,000

5603
03:43:07,587 --> 03:43:11,724
PARTICIPANTS ON QUALITY OF LIFE

5604
03:43:11,724 --> 03:43:12,458
MEASURES.

5605
03:43:12,458 --> 03:43:15,461
YOU HAVE TMIST IN RED, OTHER

5606
03:43:15,461 --> 03:43:16,662
CANCER PREVENTION CONTROL IN

5607
03:43:16,662 --> 03:43:18,831
GRAY, QUALITY OF LIFE IN THE

5608
03:43:18,831 --> 03:43:23,869
DARKER GRAY, TREATMENT TRIALS IN

5609
03:43:23,869 --> 03:43:25,738
BLUE.

5610
03:43:25,738 --> 03:43:27,273
PERHAPS THE MOST IMPORTANT PART

5611
03:43:27,273 --> 03:43:33,179
OF THE NCORP IS OUR CONTRIBUTION

5612
03:43:33,179 --> 03:43:34,380
TO DIVERSITY AND

5613
03:43:34,380 --> 03:43:35,615
REPRESENTATIVENESS OF OUR

5614
03:43:35,615 --> 03:43:36,649
POPULATIONS.

5615
03:43:36,649 --> 03:43:38,985
YOU CAN SEE HERE THAT IN

5616
03:43:38,985 --> 03:43:41,053
TREATMENT TRIALS NCORP

5617
03:43:41,053 --> 03:43:41,721
CONTRIBUTES 25% OF MINORITIES,

5618
03:43:41,721 --> 03:43:44,223
AND OF COURSE AS YOU WOULD HOPE

5619
03:43:44,223 --> 03:43:48,494
AND EXPECT THE MINORITY BASES

5620
03:43:48,494 --> 03:43:49,929
CONTRIBUTE 43% OF MINORITIES IN

5621
03:43:49,929 --> 03:43:51,664
TERMS OF THEIR TOTAL

5622
03:43:51,664 --> 03:43:51,998
CONTRIBUTION.

5623
03:43:51,998 --> 03:43:53,432
AND LOOKING AT CANCER PREVENTION

5624
03:43:53,432 --> 03:43:54,634
AND CONTROL YOU SEE THE SAME

5625
03:43:54,634 --> 03:43:56,035
PATTERNS HERE.

5626
03:43:56,035 --> 03:43:59,772
THIS HIGH NUMBER OF 72 IS

5627
03:43:59,772 --> 03:44:01,741
RELATED TO HISPANIC POPULATIONS

5628
03:44:01,741 --> 03:44:04,076
BEING ENROLLED IN TMIST AND

5629
03:44:04,076 --> 03:44:07,647
INTERNATIONAL SITES.

5630
03:44:07,647 --> 03:44:10,383
SO, NCORP FOR THOSE THAT ARE NOT

5631
03:44:10,383 --> 03:44:11,917
DEEPLY SORT OF EMBEDDED IN

5632
03:44:11,917 --> 03:44:14,987
NCORP, MAY BE A BIT OF MYSTERY,

5633
03:44:14,987 --> 03:44:18,491
HOW DO YOU GET A STUDY GOING IN

5634
03:44:18,491 --> 03:44:18,691
NCORP?

5635
03:44:18,691 --> 03:44:20,126
I ASKED BRANDI TO PUT THIS

5636
03:44:20,126 --> 03:44:21,093
TOGETHER BECAUSE I THOUGHT IT

5637
03:44:21,093 --> 03:44:22,194
WAS IMPORTANT TO UNDERSTAND

5638
03:44:22,194 --> 03:44:23,295
THERE'S TWO PATHS.

5639
03:44:23,295 --> 03:44:27,366
ONE IS WITHIN THE NCORP, YOU

5640
03:44:27,366 --> 03:44:29,001
DEVELOP A PROPOSAL, BASES HAVE

5641
03:44:29,001 --> 03:44:30,002
BEEN FUNDING, YOU BRING

5642
03:44:30,002 --> 03:44:30,636
SOMETHING FORWARD.

5643
03:44:30,636 --> 03:44:33,939
IT'S NOT THE ONLY WAY YOU CAN

5644
03:44:33,939 --> 03:44:35,808
GET INTO NCORP.

5645
03:44:35,808 --> 03:44:37,276
SO, THE TRADITIONAL PATH THE

5646
03:44:37,276 --> 03:44:38,110
INVESTIGATORS WITHIN THE

5647
03:44:38,110 --> 03:44:39,745
RESEARCH BASE WORKING GROUPS

5648
03:44:39,745 --> 03:44:41,814
DEVELOP A CONCEPT THAT IS VETTED

5649
03:44:41,814 --> 03:44:44,250
WITH THE OTHER RESEARCHERS AND

5650
03:44:44,250 --> 03:44:44,650
COMMUNITY MEMBERS.

5651
03:44:44,650 --> 03:44:46,986
THEN YOU HAVE TO GET THE

5652
03:44:46,986 --> 03:44:48,621
RESEARCH BASES TO APPROVE.

5653
03:44:48,621 --> 03:44:50,256
AND THEN IT'S SUBMITTED TO THE

5654
03:44:50,256 --> 03:44:52,224
NCI REVIEW, REVIEWED BY THE

5655
03:44:52,224 --> 03:44:58,030
STEERING COMMITTEE, AND MOVES TO

5656
03:44:58,030 --> 03:45:00,132
PROTOCOL DEVELOPMENT. 

5657
03:45:00,132 --> 03:45:02,401
YOUR OWN WAY IS TO BRING YOUR

5658
03:45:02,401 --> 03:45:07,006
OWN R01 FUNDING TO THE NCORP,

5659
03:45:07,006 --> 03:45:09,709
SAME PATHWAY BUT USE THE NCORP

5660
03:45:09,709 --> 03:45:10,710
INFRASTRUCTURE HOPEFULLY TO

5661
03:45:10,710 --> 03:45:13,979
REDUCE OVERALL COSTS OF DOING

5662
03:45:13,979 --> 03:45:15,748
THE STUDY.

5663
03:45:15,748 --> 03:45:20,653
THIS WAS A PRIORITY FROM 2015,

5664
03:45:20,653 --> 03:45:23,289
THIS CAME OUT OF A STRATEGIC

5665
03:45:23,289 --> 03:45:25,491
PLANNING PROCESS, REALLY LOOKING

5666
03:45:25,491 --> 03:45:27,126
AT SYMPTOM MANAGEMENT, QUALITY

5667
03:45:27,126 --> 03:45:28,127
OF LIFE STRATEGIC PRIORITIES.

5668
03:45:28,127 --> 03:45:35,434
AS YOU CAN SEE THE FIRST TIER IS

5669
03:45:35,434 --> 03:45:35,901
COGNITIVE IMPAIRMENT,

5670
03:45:35,901 --> 03:45:36,869
NEUROTOXICITY, CARDIOVASCULAR

5671
03:45:36,869 --> 03:45:37,670
TOXICITY, FATIGUE IN

5672
03:45:37,670 --> 03:45:38,504
CANCER-SPECIFIC PAIN, THE SECOND

5673
03:45:38,504 --> 03:45:40,806
ORDER OF PRIORITIES IS SLEEP

5674
03:45:40,806 --> 03:45:45,077
DISORDERS, BONE AND HEALTH

5675
03:45:45,077 --> 03:45:47,680
TOXICITY, METABOLIC TOXICITY,

5676
03:45:47,680 --> 03:45:49,215
PSYCHOLOGICAL STRESS.

5677
03:45:49,215 --> 03:45:50,349
THESE ARE SOME EXAMPLES.

5678
03:45:50,349 --> 03:45:52,184
I'M NOT GOING TO DRAG YOU

5679
03:45:52,184 --> 03:45:54,587
THROUGH ALL THIS, I'LL TRY TO

5680
03:45:54,587 --> 03:45:58,324
KEEP TO TIME.

5681
03:45:58,324 --> 03:46:00,092
WE HAVE ACTIVITIES ONGOING OR

5682
03:46:00,092 --> 03:46:02,361
COMPLETED TRIALS IN COGNITIVE

5683
03:46:02,361 --> 03:46:04,330
IMPAIRMENT, LIKE A RANDOMIZED

5684
03:46:04,330 --> 03:46:06,766
PHASE 3 TRIALS OF -- I CAN NEVER

5685
03:46:06,766 --> 03:46:11,971
GET THE NAME RIGHT, MOMANTIN AND

5686
03:46:11,971 --> 03:46:14,073
WHOLE BRAIN RADIOTHERAPY WITH

5687
03:46:14,073 --> 03:46:22,815
AND WITHOUT HIPPOCAMPAL VOIDANCE

5688
03:46:22,815 --> 03:46:24,784
IN PATIENTS, NRG, C COG TRIAL

5689
03:46:24,784 --> 03:46:25,851
LOOKING AT THIS DRUG.

5690
03:46:25,851 --> 03:46:29,388
THIS IS THE UNIVERSITY OF

5691
03:46:29,388 --> 03:46:32,391
ROCHESTER LOOKING AT WAYS TO

5692
03:46:32,391 --> 03:46:39,765
TREAT CIPN, ANOTHER ONE IN THE

5693
03:46:39,765 --> 03:46:44,703
ALLIANCE CIPN, AND

5694
03:46:44,703 --> 03:46:46,872
CARDIOTOXICITY FOR CHILDHOOD

5695
03:46:46,872 --> 03:46:47,706
CANCER SURVIVORS, TOXICITY.

5696
03:46:47,706 --> 03:46:49,175
THIS IS A SMALL LIST OF THINGS

5697
03:46:49,175 --> 03:46:51,944
THAT GO ON IN THE NCORP.

5698
03:46:51,944 --> 03:46:53,679
OBVIOUSLY THE NCORP HAS BEEN

5699
03:46:53,679 --> 03:46:55,548
ACTIVE IN SCREENING TRIALS.

5700
03:46:55,548 --> 03:46:57,616
YOU'RE FAMILIAR WITH TMIST,

5701
03:46:57,616 --> 03:47:02,421
WHICH WE JUST HIT, CLOSE TO

5702
03:47:02,421 --> 03:47:04,156
HITTING OUR 108th ENROLLMENT

5703
03:47:04,156 --> 03:47:04,590
TARGET.

5704
03:47:04,590 --> 03:47:06,759
WE'RE AT 140 AS OF TWO WEEKS

5705
03:47:06,759 --> 03:47:09,962
AGO, OR A WEEK-AND-A-HALF AGO.

5706
03:47:09,962 --> 03:47:14,867
THIS IS BEING RUN BY ECOG-ACRIN,

5707
03:47:14,867 --> 03:47:22,007
AND THIS IS 2D VERSUS 3D

5708
03:47:22,007 --> 03:47:23,876
MAMMOGRAPHY FOR FOUR YEARS, AND

5709
03:47:23,876 --> 03:47:27,746
NRG LOOKING AT FIVE VERSUS

5710
03:47:27,746 --> 03:47:35,054
TEN-YEAR COLONOSCOPY FOR 1 OR 2

5711
03:47:35,054 --> 03:47:35,721
NON-GRADE ADENOMAS TO ESCALATE

5712
03:47:35,721 --> 03:47:35,955
FOLLOW.

5713
03:47:35,955 --> 03:47:38,591
THIS CAME OUT OF THE REVIEW OF

5714
03:47:38,591 --> 03:47:40,459
THE TMIST TRIAL, WE'VE

5715
03:47:40,459 --> 03:47:42,194
IMPLEMENTED ACROSS THE DIVISION

5716
03:47:42,194 --> 03:47:44,063
OF CANCER PREVENTION NOT JUST

5717
03:47:44,063 --> 03:47:48,300
WITHIN NCORP BUT ACROSS THE

5718
03:47:48,300 --> 03:47:53,372
DIVISION NEW SCREENING TRIAL

5719
03:47:53,372 --> 03:47:55,975
REQUIREMENTS, SAMPLE SIZED

5720
03:47:55,975 --> 03:47:56,742
APPROPRIATELY JUSTIFIED,

5721
03:47:56,742 --> 03:47:58,744
ELIGIBILITY CRITERIA DEFINED.

5722
03:47:58,744 --> 03:47:59,612
RECRUITMENT PLANNING OVERALL

5723
03:47:59,612 --> 03:48:02,248
MINORITY RECRUITMENT PLANS HAVE

5724
03:48:02,248 --> 03:48:04,216
TO BE DETAILED.

5725
03:48:04,216 --> 03:48:05,084
NON-ENGLISH SPEAKERS HAVE TO BE

5726
03:48:05,084 --> 03:48:05,517
INCLUDED.

5727
03:48:05,517 --> 03:48:07,720
WE HAVE TO MAKE ACCOMMODATIONS

5728
03:48:07,720 --> 03:48:08,721
FOR THAT, OBVIOUSLY.

5729
03:48:08,721 --> 03:48:10,956
AND PATIENT ADVISORY BOARDS FOR

5730
03:48:10,956 --> 03:48:12,091
ANY TRIALS OVER 10,000.

5731
03:48:12,091 --> 03:48:14,293
AND THEN WE SET UP MILESTONES

5732
03:48:14,293 --> 03:48:16,896
AND MONITORING AND WE'VE SHUT

5733
03:48:16,896 --> 03:48:21,533
DOWN ONE TRIAL OR PIVOTED FROM

5734
03:48:21,533 --> 03:48:31,477
SORT OF AN ACTIVE FOLLOW-UP TO A

5735
03:48:31,477 --> 03:48:34,346
PROSPECTIVE STUDY.

5736
03:48:34,346 --> 03:48:36,348
WE PUT STRINGENT CRITERIA, YOU

5737
03:48:36,348 --> 03:48:37,750
HAVE TO HIT THESE LOW LEVEL

5738
03:48:37,750 --> 03:48:39,018
BENCHMARKS BUT YOU HAVE TO HIT

5739
03:48:39,018 --> 03:48:41,353
THEM SO IF YOU HAVEN'T HIT 10%

5740
03:48:41,353 --> 03:48:43,122
OF YOUR ACCRUAL BY 25% OF THE

5741
03:48:43,122 --> 03:48:45,624
ACCRUAL TIME, YOU GET A YELLOW

5742
03:48:45,624 --> 03:48:45,858
FLAG.

5743
03:48:45,858 --> 03:48:47,693
YOU GET TWO YELLOW FLAGS, WE'LL

5744
03:48:47,693 --> 03:48:49,128
SHUT YOU DOWN BECAUSE YOU CAN'T

5745
03:48:49,128 --> 03:48:49,795
DO IT.

5746
03:48:49,795 --> 03:48:51,430
THAT'S THE POINT.

5747
03:48:51,430 --> 03:48:52,831
OTHERWISE THESE THINGS GO ON

5748
03:48:52,831 --> 03:48:55,267
FOREVER AND WE DON'T ACHIEVE OUR

5749
03:48:55,267 --> 03:48:56,669
GOALS, UNFAIR TO PARTICIPANTS

5750
03:48:56,669 --> 03:48:56,835
TOO.

5751
03:48:56,835 --> 03:49:01,707
SO WE HAD TO PUT IN SOME NEW

5752
03:49:01,707 --> 03:49:02,675
RULES.

5753
03:49:02,675 --> 03:49:06,645
WE ALSO -- NCORP SUPPORTS THE

5754
03:49:06,645 --> 03:49:09,081
CANCER CARE DELIVERY PORTFOLIO,

5755
03:49:09,081 --> 03:49:12,384
THERE ARE 30 PROTOCOLS, 12 OPEN,

5756
03:49:12,384 --> 03:49:13,619
9 CLOSED TO ACCRUAL, 9

5757
03:49:13,619 --> 03:49:14,954
COMPLETED, ADDRESSING A BROAD

5758
03:49:14,954 --> 03:49:20,993
RANGE OF CARE DELIVERY GAPS,

5759
03:49:20,993 --> 03:49:21,927
GUIDELINE ADHERENCE,

5760
03:49:21,927 --> 03:49:23,696
EXPENDITURES, ACCESSIBILITY,

5761
03:49:23,696 --> 03:49:25,164
DECISION MAKING, IMPLEMENTATION

5762
03:49:25,164 --> 03:49:27,900
SCIENCE, CASE MANAGEMENT, SO

5763
03:49:27,900 --> 03:49:28,467
FORTH.

5764
03:49:28,467 --> 03:49:33,472
AND THIS IS SORT OF A BREAKDOWN,

5765
03:49:33,472 --> 03:49:35,774
30 APPROVED PROTOCOLS, 18

5766
03:49:35,774 --> 03:49:39,111
RANDOMIZED, 13 PRACTICES

5767
03:49:39,111 --> 03:49:42,614
RANDOMIZATION, ACCRUALS 12,000

5768
03:49:42,614 --> 03:49:45,284
NON-PATIENTS, 2300 PRACTICES,

5769
03:49:45,284 --> 03:49:50,222
839 MINORITY PATIENT ACCRUAL,

5770
03:49:50,222 --> 03:49:50,522
23.4%.

5771
03:49:50,522 --> 03:49:52,858
JUST TO BRING THIS TO A CLOSE I

5772
03:49:52,858 --> 03:49:58,964
WANT TO EMPHASIZE THE NCORP IS A

5773
03:49:58,964 --> 03:49:59,832
COMMUNITY ACADEMIC PARTNERSHIP

5774
03:49:59,832 --> 03:50:02,134
INCREASING DIVERSITY OF ACCRUAL

5775
03:50:02,134 --> 03:50:03,335
AND GENERALIZABILITY OF RESULTS.

5776
03:50:03,335 --> 03:50:06,739
AGAIN, BECAUSE WE HAVE THE

5777
03:50:06,739 --> 03:50:07,740
COMMUNITY ONCOLOGISTS AND

5778
03:50:07,740 --> 03:50:11,777
COMMUNITY INVOLVED, IT REALLY WE

5779
03:50:11,777 --> 03:50:16,181
HOPE WILL LEAD TO  FASTER

5780
03:50:16,181 --> 03:50:17,483
ADOPTION OF EVIDENCE GENERATED

5781
03:50:17,483 --> 03:50:20,386
BY NCORP BECAUSE WE'RE TALKING

5782
03:50:20,386 --> 03:50:21,887
TO PEOPLE DELIVERING CARE,

5783
03:50:21,887 --> 03:50:23,055
GRADING THE EVIDENCE WE WANT

5784
03:50:23,055 --> 03:50:26,325
THEM TO IMPLEMENT.

5785
03:50:26,325 --> 03:50:27,459
ADOPTION OF IMPROVED CLINICAL

5786
03:50:27,459 --> 03:50:28,761
PRACTICE AND CARE, FOCUS ON

5787
03:50:28,761 --> 03:50:30,195
IMPORTANCE OF QUALITY OF LIFE,

5788
03:50:30,195 --> 03:50:31,463
INCORPORATING PATIENT EXPERIENCE

5789
03:50:31,463 --> 03:50:34,033
AND DEVELOPING INTERVENTIONS TO

5790
03:50:34,033 --> 03:50:35,768
IMPROVE THE CANCER EXPERIENCE.

5791
03:50:35,768 --> 03:50:37,236
AND I AGAIN WILL SAY THIS ON A

5792
03:50:37,236 --> 03:50:40,072
PERSONAL NOTE, SO THIS IS THE

5793
03:50:40,072 --> 03:50:42,007
8-YEAR ANNIVERSARY OF MY WIFE

5794
03:50:42,007 --> 03:50:43,776
PASSING, QUALITY OF LIFE IS A

5795
03:50:43,776 --> 03:50:44,576
REAL THING.

5796
03:50:44,576 --> 03:50:46,078
WE HAVE TO TAKE CARE OF THE

5797
03:50:46,078 --> 03:50:47,379
WHOLE PERSON, NOT JUST THE

5798
03:50:47,379 --> 03:50:49,381
CANCER, WHICH IS WHAT HAPPENED

5799
03:50:49,381 --> 03:50:52,117
TO MY WIFE A LOT OF FOCUS ON THE

5800
03:50:52,117 --> 03:50:53,752
CANCER, NOT ENOUGH FOCUS ON HER

5801
03:50:53,752 --> 03:50:56,822
QUALITY OF LIFE, AND I CAN'T --

5802
03:50:56,822 --> 03:50:59,558
I WASN'T AS A CANCER RESEARCHER

5803
03:50:59,558 --> 03:51:00,559
WASN'T FULLY SENSITIZED UNTIL I

5804
03:51:00,559 --> 03:51:06,031
HAD TO WATCH IT UP CLOSE AND

5805
03:51:06,031 --> 03:51:06,298
PERSONAL.

5806
03:51:06,298 --> 03:51:10,736
FOCUS ON -- I'M SORRY, NCORP IS

5807
03:51:10,736 --> 03:51:15,007
TRANSNCI COLLABORATION, WE WORK

5808
03:51:15,007 --> 03:51:18,077
WITH DCTD, DCCPS, OPENING A

5809
03:51:18,077 --> 03:51:18,811
PROTOCOL WITH CCHE.

5810
03:51:18,811 --> 03:51:20,345
YOU'LL BE SEEING THIS IN THREE

5811
03:51:20,345 --> 03:51:24,516
MONTHS BECAUSE WE'RE COMING BACK

5812
03:51:24,516 --> 03:51:25,818
FOR RECOMPETITION, AND DECEMBER

5813
03:51:25,818 --> 03:51:27,986
BOARD MEETING, A WAY TO PRIME

5814
03:51:27,986 --> 03:51:29,321
YOU FOR THIS IS COMING.

5815
03:51:29,321 --> 03:51:32,724
I WILL SAY ONE OF OUR

5816
03:51:32,724 --> 03:51:35,094
ASPIRATIONS FOR THE NCORP IS

5817
03:51:35,094 --> 03:51:37,429
INCUBATOR PROGRAM TO HELP NEW

5818
03:51:37,429 --> 03:51:38,530
APPLICANTS COMPETE SUCCESSFULLY

5819
03:51:38,530 --> 03:51:39,631
TO JOIN NCORP.

5820
03:51:39,631 --> 03:51:41,467
IT'S VERY CHALLENGING TO BE ON

5821
03:51:41,467 --> 03:51:44,002
THE OUTSIDE AND TO COMPETE

5822
03:51:44,002 --> 03:51:44,436
SUCCESSFULLY.

5823
03:51:44,436 --> 03:51:46,839
WE'RE HOPING NOT ONLY THAT WE

5824
03:51:46,839 --> 03:51:48,373
GET MORE DIVERSE GROUP OF

5825
03:51:48,373 --> 03:51:52,644
CLINICAL SITES INVOLVED WITH

5826
03:51:52,644 --> 03:51:53,512
NCORP, WITH DIFFERENT

5827
03:51:53,512 --> 03:51:54,713
INVESTIGATORS, AND ALSO KIND OF

5828
03:51:54,713 --> 03:51:56,482
RAISE THE LEVEL OF COMPETITION,

5829
03:51:56,482 --> 03:51:58,750
SO WE HAVE GOOD PERFORMERS, NOT

5830
03:51:58,750 --> 03:52:00,719
SO GOOD PERFORMERS IN NCORP SO

5831
03:52:00,719 --> 03:52:03,455
WE'RE HOPING THIS RAISES THE BAR

5832
03:52:03,455 --> 03:52:04,990
AND TAKES NCORP TO ANOTHER

5833
03:52:04,990 --> 03:52:05,324
LEVEL.

5834
03:52:05,324 --> 03:52:06,959
WITH THAT I'LL SAY THANK YOU

5835
03:52:06,959 --> 03:52:07,726
VERY MUCH.

5836
03:52:07,726 --> 03:52:11,563
OH, WAIT, ONE MORE SLIDE.

5837
03:52:11,563 --> 03:52:15,267
I'M STEALING SOMEBODY ELSE'S

5838
03:52:15,267 --> 03:52:16,268
LINE FROM EARLIER, QUESTIONS TO

5839
03:52:16,268 --> 03:52:18,904
THINK ABOUT AS WE GO DOWN THE

5840
03:52:18,904 --> 03:52:19,104
ROAD.

5841
03:52:19,104 --> 03:52:20,839
HOW CAN WE EXPAND TO ENGAGE MORE

5842
03:52:20,839 --> 03:52:22,274
PEOPLE IN CLINICAL TRIALS WHERE

5843
03:52:22,274 --> 03:52:24,510
THEY LIVE?

5844
03:52:24,510 --> 03:52:26,612
BETTER ENGAGE THE LEAD ACADEMIC

5845
03:52:26,612 --> 03:52:27,779
PERFORMANCE SITES IN CANCER

5846
03:52:27,779 --> 03:52:29,414
CONTROL AND PREVENTION TRIALS?

5847
03:52:29,414 --> 03:52:32,484
HOW CAN WE BETTER COLLABORATE

5848
03:52:32,484 --> 03:52:33,352
INTERNATIONALLY CONDUCT CANCER

5849
03:52:33,352 --> 03:52:34,887
PREVENTION AND CONTROL TRIALS?

5850
03:52:34,887 --> 03:52:37,623
HOW CAN WE REDUCE WORKLOAD AT

5851
03:52:37,623 --> 03:52:39,925
SITES ENHANCING RESEARCH IMPACT

5852
03:52:39,925 --> 03:52:41,260
OF OUR TRIALS?

5853
03:52:41,260 --> 03:52:45,731
HOW CAN WE CONNECT DATA AND

5854
03:52:45,731 --> 03:52:47,032
BIOSPECIMENS FROM TRIALS AND

5855
03:52:47,032 --> 03:52:49,535
QUALITY OF LIFE TO CONTRIBUTE TO

5856
03:52:49,535 --> 03:52:51,737
RESEARCH AND HELP OUTSIDE

5857
03:52:51,737 --> 03:52:54,039
INVESTIGATORS WITH GREAT IDEAS

5858
03:52:54,039 --> 03:52:56,775
ENGAGE WITH THIS NETWORK.

5859
03:52:56,775 --> 03:52:58,577
I'LL TURN IT OVER TO JIM AND

5860
03:52:58,577 --> 03:53:00,846
THEN WE'LL DO 15 MINUTES AFTER

5861
03:53:00,846 --> 03:53:05,350
THAT. 

5862
03:53:05,350 --> 03:53:05,617
>> YES.

5863
03:53:05,617 --> 03:53:08,187
>> THANK YOU.

5864
03:53:08,187 --> 03:53:10,189
[APPLAUSE] 

5865
03:53:10,189 --> 03:53:12,824
>> I BELIEVE JIM IS IN THE

5866
03:53:12,824 --> 03:53:15,661
VIRTUAL ROOM.

5867
03:53:15,661 --> 03:53:16,328
>> I'M HERE.

5868
03:53:16,328 --> 03:53:20,832
I'D LIKE TO THANK THE NCTN

5869
03:53:20,832 --> 03:53:22,367
PRESENTATION AND THANK THE NCAB

5870
03:53:22,367 --> 03:53:24,469
FOR MY ABILITY TO GIVE THIS

5871
03:53:24,469 --> 03:53:24,803
PRESENTATION.

5872
03:53:24,803 --> 03:53:29,374
BEFORE I START IT'S REALLY

5873
03:53:29,374 --> 03:53:31,877
IMPORTANT THAT I NOTE WITH GREAT

5874
03:53:31,877 --> 03:53:33,645
APPRECIATION THE HUNDREDS OF

5875
03:53:33,645 --> 03:53:36,181
THOUSANDS OF PATIENTS WHO HAVE

5876
03:53:36,181 --> 03:53:37,816
PARTICIPATED IN THE NCTN TRIALS

5877
03:53:37,816 --> 03:53:41,553
OVER MORE THAN THREE OR FOUR

5878
03:53:41,553 --> 03:53:41,954
DECADES.

5879
03:53:41,954 --> 03:53:42,754
WITHOUT THEIR PARTICIPATION

5880
03:53:42,754 --> 03:53:44,957
THERE WOULD BE NO PRESENTATION

5881
03:53:44,957 --> 03:53:46,158
TODAY, AND MAJOR ADVANCES WOULD

5882
03:53:46,158 --> 03:53:47,559
NOT HAVE OCCURRED.

5883
03:53:47,559 --> 03:53:49,661
I THINK IT'S EQUALLY IMPORTANT

5884
03:53:49,661 --> 03:53:53,932
TO SAY THAT WE WOULD NOT HAVE AN

5885
03:53:53,932 --> 03:53:56,535
NCTN WITHOUT THE TENS OF

5886
03:53:56,535 --> 03:54:02,774
THOUSANDS OF HEALTHCARE WORKERS,

5887
03:54:02,774 --> 03:54:03,976
RESEARCH NURSES, DATA MANAGERS,

5888
03:54:03,976 --> 03:54:05,210
ADVOCATES, AND PRINCIPAL

5889
03:54:05,210 --> 03:54:06,511
INVESTIGATORS AND OTHER

5890
03:54:06,511 --> 03:54:08,580
INVESTIGATORS WHO HAVE WORKED

5891
03:54:08,580 --> 03:54:10,882
TIRELESSLY TO MAKE THIS NETWORK

5892
03:54:10,882 --> 03:54:11,750
SOMETHING OF NATIONAL

5893
03:54:11,750 --> 03:54:12,050
IMPORTANCE.

5894
03:54:12,050 --> 03:54:17,122
I ALSO HAVE TO CALL OUT THE

5895
03:54:17,122 --> 03:54:18,223
OPERATIONS CENTERS, STAFF

5896
03:54:18,223 --> 03:54:19,291
CENTERS, ALL THE OTHER

5897
03:54:19,291 --> 03:54:20,726
COORDINATING CENTERS THAT ARE

5898
03:54:20,726 --> 03:54:22,361
THE GLUE FOR THIS NETWORK.

5899
03:54:22,361 --> 03:54:23,428
I'LL MENTION THEM BUT I THINK

5900
03:54:23,428 --> 03:54:25,530
THEY NEED TO BE CALLED OUT

5901
03:54:25,530 --> 03:54:26,031
SPECIFICALLY.

5902
03:54:26,031 --> 03:54:28,400
THEY DO A GREAT JOB.

5903
03:54:28,400 --> 03:54:30,302
AND THE LAST FIVE YEARS AS

5904
03:54:30,302 --> 03:54:31,870
YOU'LL SEE BECAUSE OF THE

5905
03:54:31,870 --> 03:54:33,872
PANDEMIC HAVE REALLY NOT BEEN

5906
03:54:33,872 --> 03:54:34,072
EASY.

5907
03:54:34,072 --> 03:54:42,014
COULD I HAVE MY NEXT SLIDE.

5908
03:54:42,014 --> 03:54:43,448
BEFORE WE START MUCH AS PHIL DID

5909
03:54:43,448 --> 03:54:45,484
I'D LIKE TO TALK ABOUT THE

5910
03:54:45,484 --> 03:54:47,219
TRANSFORMATION OF THE FORMER

5911
03:54:47,219 --> 03:54:51,723
COOPERATIVE GROUP PROGRAM INTO

5912
03:54:51,723 --> 03:54:53,025
THE NCTN AFTER EXTENSIVE

5913
03:54:53,025 --> 03:54:56,528
INTRAMURAL REVIEW AND INPUT IN

5914
03:54:56,528 --> 03:54:57,529
2014.

5915
03:54:57,529 --> 03:55:00,132
WITH THAT INPUT, WE CHANGED THE

5916
03:55:00,132 --> 03:55:02,567
PROGRAM INFRASTRUCTURE IN A

5917
03:55:02,567 --> 03:55:06,038
MAJOR WAY TO HELP HARMONIZE

5918
03:55:06,038 --> 03:55:07,673
VARIETY THROUGH REMOTE

5919
03:55:07,673 --> 03:55:09,441
COLLABORATIONS, TO FOCUS ON

5920
03:55:09,441 --> 03:55:11,510
QUESTIONS THAT ARE NOT WELL

5921
03:55:11,510 --> 03:55:15,247
SUPPORTED IN THE COMMERCIAL

5922
03:55:15,247 --> 03:55:16,982
ENVIRONMENT, TO PRIORITIZE

5923
03:55:16,982 --> 03:55:17,716
TRIAL, INCORPORATE INNOVATIVE

5924
03:55:17,716 --> 03:55:20,252
SCIENCE IN CLINICAL TRIAL

5925
03:55:20,252 --> 03:55:24,523
DESIGN, AND PROVIDE LARGE SCALE

5926
03:55:24,523 --> 03:55:25,857
TESTING HE MOLECULARLY TARGET

5927
03:55:25,857 --> 03:55:28,593
AND DEFINED AND INCORPORATE INTO

5928
03:55:28,593 --> 03:55:32,864
THE NCTN PORTFOLIO, WITH GREATER

5929
03:55:32,864 --> 03:55:35,033
EMPHASIS ON TREATMENT OF RARE

5930
03:55:35,033 --> 03:55:35,267
TUMORS.

5931
03:55:35,267 --> 03:55:37,002
FINALLY, VERY IMPORTANTLY, TO

5932
03:55:37,002 --> 03:55:38,537
MAINTAIN COMMITMENT TO CONDUCT

5933
03:55:38,537 --> 03:55:43,575
TRIALS IN DIVERSE AND SPECIAL

5934
03:55:43,575 --> 03:55:43,875
POPULATIONS.

5935
03:55:43,875 --> 03:55:44,676
NEXT SLIDE.

5936
03:55:44,676 --> 03:55:48,380
THERE ARE SIX MAIN COMPONENTS TO

5937
03:55:48,380 --> 03:55:50,682
THE NCTN FUNDING PROGRAM.

5938
03:55:50,682 --> 03:55:54,619
THE U.S. COOPERATIVE GROUP

5939
03:55:54,619 --> 03:55:56,922
OPERATION CENTERS, GROUP STATS

5940
03:55:56,922 --> 03:56:00,192
AND DATA MANAGEMENT CENTERS,

5941
03:56:00,192 --> 03:56:00,959
CANADIAN COLLABORATING TRIALS

5942
03:56:00,959 --> 03:56:03,628
GROUP, ALL OF THE LEAD ACADEMIC

5943
03:56:03,628 --> 03:56:05,364
PARTICIPATING SITES, ALL OF

5944
03:56:05,364 --> 03:56:07,065
THEIR AFFILIATES WHICH COME IN

5945
03:56:07,065 --> 03:56:10,602
AT GREATER THAN 2,000 SITES

5946
03:56:10,602 --> 03:56:15,207
CONDUCTING TRIALS OF THE NCTN.

5947
03:56:15,207 --> 03:56:17,509
OUR IMAGING AND CORE SERVICE

5948
03:56:17,509 --> 03:56:19,244
CENTERS AND INTEGRATED

5949
03:56:19,244 --> 03:56:20,412
TRANSLATIONAL SCIENCE AWARDS FOR

5950
03:56:20,412 --> 03:56:21,213
PILOT PROJECTS.

5951
03:56:21,213 --> 03:56:23,749
IT'S IMPORTANT TO NOTE THAT

5952
03:56:23,749 --> 03:56:25,384
UNDER A SEPARATE RFA WE ALSO

5953
03:56:25,384 --> 03:56:28,420
FUND TUMOR BANKS FOR EACH OF

5954
03:56:28,420 --> 03:56:30,922
THESE GROUPS SO CRITICAL

5955
03:56:30,922 --> 03:56:32,691
SPECIMENS, CORRELATIVE STUDIES,

5956
03:56:32,691 --> 03:56:34,893
SOME NEEDED FOR ELIGIBILITY, ARE

5957
03:56:34,893 --> 03:56:37,295
COLLECTED AND MAINTAINED AND

5958
03:56:37,295 --> 03:56:39,498
ORGANIZED FOR SEPARATE USE

5959
03:56:39,498 --> 03:56:41,833
DURING THE CONDUCT AND AFTER

5960
03:56:41,833 --> 03:56:44,703
COMPLETION OF THE TRIALS.

5961
03:56:44,703 --> 03:56:46,004
FINALLY I CANNOT EMPHASIZE

5962
03:56:46,004 --> 03:56:47,539
ENOUGH WHAT DR. CASTLE HAS JUST

5963
03:56:47,539 --> 03:56:50,509
PRESENTED TO YOU, THE CRITICAL

5964
03:56:50,509 --> 03:56:53,278
IMPORTANCE OF OUR NCORP SITES IN

5965
03:56:53,278 --> 03:56:56,214
THE MAINTENANCE OF OUR ACCRUAL

5966
03:56:56,214 --> 03:56:57,949
GOALS FOR TREATMENT TRIALS.

5967
03:56:57,949 --> 03:57:01,253
THEY ARE ESSENTIAL.

5968
03:57:01,253 --> 03:57:03,655
NEXT SLIDE.

5969
03:57:03,655 --> 03:57:06,491
SOMETHING THAT IS NOT AS WELL

5970
03:57:06,491 --> 03:57:08,026
UNDERSTOOD IN THE EXTRAMURAL

5971
03:57:08,026 --> 03:57:09,694
COMMUNITY BECAUSE IT'S NOT

5972
03:57:09,694 --> 03:57:12,964
GRANTS FUNDED ARE SERIES OF

5973
03:57:12,964 --> 03:57:15,033
CONTRACTS, DIVISION OF CANCER

5974
03:57:15,033 --> 03:57:16,134
TREATMENT AND DIAGNOSIS

5975
03:57:16,134 --> 03:57:19,971
MAINTAINS NOT ONLY FOR OURSELVES

5976
03:57:19,971 --> 03:57:21,406
BUT OTHER CLINICAL TRIALS

5977
03:57:21,406 --> 03:57:24,242
NETWORKS ACROSS THE NCI.

5978
03:57:24,242 --> 03:57:26,311
AND THESE CONTRACTS SUPPORT

5979
03:57:26,311 --> 03:57:28,713
INFORMATION SECURITY, STUDY

5980
03:57:28,713 --> 03:57:29,915
ADMINISTRATION AND LOGISTICS,

5981
03:57:29,915 --> 03:57:33,885
CLINICAL DATA CAPTURE AND

5982
03:57:33,885 --> 03:57:34,753
REPORTING.

5983
03:57:34,753 --> 03:57:36,721
IN FACT, ENROLLMENT AND CLINICAL

5984
03:57:36,721 --> 03:57:37,322
TRIAL DATA MANAGEMENT SYSTEMS

5985
03:57:37,322 --> 03:57:41,226
ARE AT THE HEART OF OUR DATA

5986
03:57:41,226 --> 03:57:41,526
MANAGEMENT.

5987
03:57:41,526 --> 03:57:43,195
PROVIDE REGULATORY MONITORING

5988
03:57:43,195 --> 03:57:45,597
AND REPORTING.

5989
03:57:45,597 --> 03:57:47,432
INCLUDING INVESTIGATOR

5990
03:57:47,432 --> 03:57:48,066
CREDENTIALING.

5991
03:57:48,066 --> 03:57:51,970
AND NCI, CIRB AND REGULATORY

5992
03:57:51,970 --> 03:57:52,771
SUPPORT INCLUDING MAINTAINING

5993
03:57:52,771 --> 03:57:54,806
UPDATED 1572 FORMS FOR ALL OF

5994
03:57:54,806 --> 03:57:56,408
THOSE INVESTIGATORS ACROSS ALL

5995
03:57:56,408 --> 03:57:57,209
THOSE SITES.

5996
03:57:57,209 --> 03:58:00,479
AS WELL AS SPONSORSHIP OF IND

5997
03:58:00,479 --> 03:58:02,481
ACTIVITIES ON SELECT NCTN

5998
03:58:02,481 --> 03:58:02,914
TRIALS.

5999
03:58:02,914 --> 03:58:06,651
WE ALSO PLAY AN IMPORTANT ROLE

6000
03:58:06,651 --> 03:58:07,619
IN TERMS OF AUDITING FUNCTION

6001
03:58:07,619 --> 03:58:10,388
FOR DATA QUALITY AND CONTROL,

6002
03:58:10,388 --> 03:58:12,791
AND FOR THE MAINTENANCE OF

6003
03:58:12,791 --> 03:58:16,928
CORRELATIVE SCIENCE STUDY DATA.

6004
03:58:16,928 --> 03:58:18,263
NEXT SLIDE.

6005
03:58:18,263 --> 03:58:21,766
I'D LIKE TO TAKE MY CHANCE NOW

6006
03:58:21,766 --> 03:58:24,102
TO PROVIDE YOU WITH SOME

6007
03:58:24,102 --> 03:58:25,403
PERSPECTIVE ON VARIETY OF

6008
03:58:25,403 --> 03:58:27,038
INVESTIGATIONAL STUDIES CARRIED

6009
03:58:27,038 --> 03:58:29,007
OUT BY THE NCTN.

6010
03:58:29,007 --> 03:58:31,643
YOU'RE ALL FAMILIAR WITH THE

6011
03:58:31,643 --> 03:58:33,912
CONCLUDED NCI MATCH, PEDIATRIC

6012
03:58:33,912 --> 03:58:35,347
MATCH STUDIES, WHICH WERE

6013
03:58:35,347 --> 03:58:36,982
ESSENTIAL AND PROVIDED AN

6014
03:58:36,982 --> 03:58:40,285
IMPORTANT INPUT INTO HOW TO

6015
03:58:40,285 --> 03:58:42,254
CONDUCT STUDIES NATIONALLY.

6016
03:58:42,254 --> 03:58:45,290
BUT WE HAVE RECENTLY OPENED AND

6017
03:58:45,290 --> 03:58:53,965
ARE CONDUCTING SUCCESSOR TRIALS

6018
03:58:53,965 --> 03:58:55,600
TO MATCH, INCLUDING

6019
03:58:55,600 --> 03:58:57,369
ComboMATCH, MYELOMATCH,

6020
03:58:57,369 --> 03:58:58,370
PATIENTS FROM DIAGNOSIS THROUGH

6021
03:58:58,370 --> 03:59:02,741
RECURRENCE FOR ALL STAGES OF

6022
03:59:02,741 --> 03:59:06,011
AML, MDS, PILOT PROGRAM CALLED

6023
03:59:06,011 --> 03:59:07,779
I-MATCH, ACCRUED WELL TO TRY TO

6024
03:59:07,779 --> 03:59:10,615
UNDERSTAND WHAT KIND OF

6025
03:59:10,615 --> 03:59:13,351
MOLECULAR PLATFORM WE NEED TO

6026
03:59:13,351 --> 03:59:14,152
ENHANCE I/O THERAPY GOING

6027
03:59:14,152 --> 03:59:14,553
FORWARD.

6028
03:59:14,553 --> 03:59:17,989
ALL OF THIS COULD NOT BE DONE

6029
03:59:17,989 --> 03:59:20,525
WITHOUT A CENTRAL MOLECULAR

6030
03:59:20,525 --> 03:59:21,793
CHARACTERIZATION LABORATORY

6031
03:59:21,793 --> 03:59:24,796
SERIES THAT GOES ON AT THE

6032
03:59:24,796 --> 03:59:26,665
FREDERICK NATIONAL LAB, ALSO AT

6033
03:59:26,665 --> 03:59:29,301
MAJOR ACADEMIC SITES ACROSS THE

6034
03:59:29,301 --> 03:59:30,302
COUNTRY.

6035
03:59:30,302 --> 03:59:33,238
BUT THAT'S NOT AT ALL THE

6036
03:59:33,238 --> 03:59:35,440
COMPLETE SPECTRUM OF WHAT GOES

6037
03:59:35,440 --> 03:59:42,113
ON IN THE NCTN. 

6038
03:59:42,113 --> 03:59:44,416
MULTI-MODALITY TRIALS NEVER

6039
03:59:44,416 --> 03:59:45,951
CONDUCTED BY INDUSTRY AND STUDY

6040
03:59:45,951 --> 03:59:47,385
OF ROLE OF WEIGHT LOSS IN

6041
03:59:47,385 --> 03:59:51,056
TREATMENT OF EARLY BREAST

6042
03:59:51,056 --> 03:59:52,290
CANCER, EVALUATION OF DOSE

6043
03:59:52,290 --> 03:59:54,693
ESCALATION THERAPY, PLUS OR

6044
03:59:54,693 --> 03:59:56,895
MINUS ADT IN INTERMEDIATE

6045
03:59:56,895 --> 04:00:02,033
PROSTATE CANCER, WE ALSO DO

6046
04:00:02,033 --> 04:00:05,103
COMBINATIONS OF CHEMOTHERAPY AND

6047
04:00:05,103 --> 04:00:07,639
IMMUNOTHERAPY, FOR COLON CANCER,

6048
04:00:07,639 --> 04:00:08,440
AND STUDIES IN SPECIAL

6049
04:00:08,440 --> 04:00:11,476
POPULATIONS, SPECIAL

6050
04:00:11,476 --> 04:00:11,776
INITIATIVES.

6051
04:00:11,776 --> 04:00:13,678
AYA TRIALS HAVE BEEN A MAJOR

6052
04:00:13,678 --> 04:00:16,414
FOCUS AT THE LAST AND CURRENT

6053
04:00:16,414 --> 04:00:17,816
FUNDING PERIODS.

6054
04:00:17,816 --> 04:00:19,484
STUDIES TO BROADEN ELIGIBILITY

6055
04:00:19,484 --> 04:00:21,052
AND OUTREACH TO DIVERSE

6056
04:00:21,052 --> 04:00:23,321
POPULATIONS, I WANT TO CALL TO

6057
04:00:23,321 --> 04:00:24,522
YOUR ATTENTION AN EFFORT

6058
04:00:24,522 --> 04:00:27,258
CONDUCTED BY A WORKING GROUP OF

6059
04:00:27,258 --> 04:00:29,227
THE CLINICAL TRIALS ADVISORY

6060
04:00:29,227 --> 04:00:30,528
COMMITTEE THAT WILL LITERALLY

6061
04:00:30,528 --> 04:00:34,032
CHANGE THE ENTIRE DATA

6062
04:00:34,032 --> 04:00:37,002
MANAGEMENT PROFILE FOR STUDIES

6063
04:00:37,002 --> 04:00:38,870
NON-IND REQUIRING, AS YOU'LL SEE

6064
04:00:38,870 --> 04:00:42,807
ABOUT 40% OF OUR TRIALS IN WHICH

6065
04:00:42,807 --> 04:00:45,644
AS OF JANUARY 1, 2025,

6066
04:00:45,644 --> 04:00:46,311
REQUIREMENTS WERE WHAT WAS

6067
04:00:46,311 --> 04:00:50,348
DEEMED TO BE BY AN EXPERT PANEL

6068
04:00:50,348 --> 04:00:51,883
COMPLETELY UNNECESSARY DATA

6069
04:00:51,883 --> 04:00:54,619
ELEMENTS, NO LONGER WILL BE

6070
04:00:54,619 --> 04:00:56,688
SUBMITTED IN THESE TRIALS, AND

6071
04:00:56,688 --> 04:01:00,191
WE'LL EVALUATE WHETHER OR NOT

6072
04:01:00,191 --> 04:01:01,426
THAT ENHANCES THE ABILITY FOR US

6073
04:01:01,426 --> 04:01:06,331
TO ACCRUE AND FOR US TO CONDUCT

6074
04:01:06,331 --> 04:01:06,798
STUDIES MORE RAPIDLY.

6075
04:01:06,798 --> 04:01:09,901
WE'RE IN THE MIDST OF EFFORTS TO

6076
04:01:09,901 --> 04:01:11,236
DECENTRALIZE OUR CLINICAL

6077
04:01:11,236 --> 04:01:11,469
TRIALS.

6078
04:01:11,469 --> 04:01:15,540
THERE ARE INCREDIBLY IMPORTANT

6079
04:01:15,540 --> 04:01:16,841
DATA SHARING ACTIVITIES, NCTN

6080
04:01:16,841 --> 04:01:20,211
AND NCORP, IN THE PROCESS WHICH

6081
04:01:20,211 --> 04:01:22,614
WE TRY TO PROVIDE ACCESS TO OUR

6082
04:01:22,614 --> 04:01:24,282
BIOSPECIMENS AND AS I WILL TOUCH

6083
04:01:24,282 --> 04:01:27,452
ON AT THE END I COULD NOT GIVE

6084
04:01:27,452 --> 04:01:37,295
THIS PRESENTATION WITHOUT SAYING

6085
04:01:37,295 --> 04:01:38,630
SOMETHING ABOUT PRAGMATIC ALUM.

6086
04:01:38,630 --> 04:01:40,165
I COULD NOT PROVIDE THIS

6087
04:01:40,165 --> 04:01:40,899
PRESENTATION WITHOUT SAYING

6088
04:01:40,899 --> 04:01:44,636
SOMETHING ABOUT THE IMPACT OF

6089
04:01:44,636 --> 04:01:45,036
COVID-19.

6090
04:01:45,036 --> 04:01:47,539
YOU SEE WHERE I TERMED IN PRIOR

6091
04:01:47,539 --> 04:01:49,674
PRESENTATIONS, THE GRAND CANYON

6092
04:01:49,674 --> 04:01:50,408
OF ACCRUAL.

6093
04:01:50,408 --> 04:01:53,611
SO BETWEEN THE FIRST AND SECOND

6094
04:01:53,611 --> 04:01:57,315
AND THIRD QUARTERS OF 2020,

6095
04:01:57,315 --> 04:02:02,020
ACCRUAL TO NCTN DROPPED

6096
04:02:02,020 --> 04:02:03,588
PRECIPITOUSLYA TESTAMENT TO

6097
04:02:03,588 --> 04:02:09,060
CHANGE IN NCTN AND NCORP ALLOWED

6098
04:02:09,060 --> 04:02:10,061
GREATER ENHANCEMENT AND ABILITY

6099
04:02:10,061 --> 04:02:13,965
FOR LOCAL SITES TO DO THEIR

6100
04:02:13,965 --> 04:02:16,167
TRIALS BY TELEMEDICINE FOR US TO

6101
04:02:16,167 --> 04:02:19,204
MAKE WITH THE FDA APPROVAL MAJOR

6102
04:02:19,204 --> 04:02:24,909
CHANGES IN STUDIES THAT ALLOWED

6103
04:02:24,909 --> 04:02:26,778
A MUCH MORE LENIENT PERSPECTIVE

6104
04:02:26,778 --> 04:02:31,249
ON LOW GRADE ADVERSE EVENT

6105
04:02:31,249 --> 04:02:31,683
REPORTING.

6106
04:02:31,683 --> 04:02:34,519
WE INITIATED REMOTE CONSENT AND

6107
04:02:34,519 --> 04:02:35,920
AUDITING TECHNIQUES, AND

6108
04:02:35,920 --> 04:02:37,689
IMPORTANTLY FOR THE FIRST TIME

6109
04:02:37,689 --> 04:02:39,224
BEGAN SHIPPING ORAL AGENTS

6110
04:02:39,224 --> 04:02:41,326
DIRECTLY TO PATIENTS FROM OUR

6111
04:02:41,326 --> 04:02:42,527
INVESTIGATIONAL SITES, THE

6112
04:02:42,527 --> 04:02:44,062
PATIENTS IN RULE SITES DID NOT

6113
04:02:44,062 --> 04:02:47,132
HAVE TO DRIVE IN SOME CASES

6114
04:02:47,132 --> 04:02:50,068
HUNDREDS OF MILES TO PICK UP

6115
04:02:50,068 --> 04:02:51,503
THEIR ORAL MEDICATIONS.

6116
04:02:51,503 --> 04:02:54,239
WHAT WE HOPE IS THAT THE ORANGE

6117
04:02:54,239 --> 04:02:58,476
BAR THAT YOU SEE WHICH IS OUR

6118
04:02:58,476 --> 04:03:01,112
ACCRUAL FOR 2024 AS OF VERY

6119
04:03:01,112 --> 04:03:03,414
RECENT DATE WILL ACTUALLY REACH

6120
04:03:03,414 --> 04:03:05,717
THE ACCRUAL RATE AND PERHAPS

6121
04:03:05,717 --> 04:03:07,986
EXCEED ACCRUAL RATE IN 2021

6122
04:03:07,986 --> 04:03:10,088
WHICH WILL GET US BACK TO

6123
04:03:10,088 --> 04:03:11,723
TRAJECTORY THAT IS MUCH MORE

6124
04:03:11,723 --> 04:03:13,158
CONSISTENT WITH OUR ACCRUAL

6125
04:03:13,158 --> 04:03:19,597
GOALS OVERALL FOR THE NETWORK.

6126
04:03:19,597 --> 04:03:21,232
NEXT SLIDE.

6127
04:03:21,232 --> 04:03:22,801
LET'S TALK ABOUT CHARACTERISTICS

6128
04:03:22,801 --> 04:03:26,070
OF THE COHORT BY A PHASE IND AND

6129
04:03:26,070 --> 04:03:28,239
CANCER TYPE.

6130
04:03:28,239 --> 04:03:31,976
NOT UNEXPECTEDLY, MAJORITY OF

6131
04:03:31,976 --> 04:03:36,214
THE ACCRUAL IN NCTN IS TO PHASE

6132
04:03:36,214 --> 04:03:40,819
3 AND PHASE 2/3 CLINICAL TRIALS 

6133
04:03:40,819 --> 04:03:43,121
AS I ALLUDED TO EARLIER, IT'S

6134
04:03:43,121 --> 04:03:46,090
IMPORTANT TO POINT OUT, PERHAPS

6135
04:03:46,090 --> 04:03:48,159
NOT SOMETHING EVERYBODY

6136
04:03:48,159 --> 04:03:49,694
UNDERSTANDS, 40% OF TRIALS ARE

6137
04:03:49,694 --> 04:03:53,198
IND EXEMPT WHICH DOES ALLOW US

6138
04:03:53,198 --> 04:03:55,800
THE ABILITY TO MAKE SIGNIFICANT

6139
04:03:55,800 --> 04:03:58,570
CHANGES IN CLINICAL TRIAL DESIGN

6140
04:03:58,570 --> 04:04:00,438
AND DATA ELEMENT REPORTING AND

6141
04:04:00,438 --> 04:04:06,744
OTHER ASPECTS OF TRIALS TO

6142
04:04:06,744 --> 04:04:07,946
SIMPLIFY, DECENTRALIZE, MAKE

6143
04:04:07,946 --> 04:04:09,614
ACCRUAL EASIER FOR 2,000 SITES

6144
04:04:09,614 --> 04:04:11,149
CRITICAL TO OUR SUCCESS.

6145
04:04:11,149 --> 04:04:14,118
ON THE RIGHT SIDE OF THE GRAPH

6146
04:04:14,118 --> 04:04:15,854
YOU SHOULD NOT BE SURPRISED WITH

6147
04:04:15,854 --> 04:04:18,523
THE FACT OVER 60% OF THE

6148
04:04:18,523 --> 04:04:20,358
PEDIATRIC ACCRUAL IS TO A.L.L.,

6149
04:04:20,358 --> 04:04:21,793
WHERE MOST OF THE PATIENTS ARE.

6150
04:04:21,793 --> 04:04:23,761
IF YOU LOOK AT THE ADULT

6151
04:04:23,761 --> 04:04:27,065
CANCERS, WHAT YOU SEE IS AGAIN

6152
04:04:27,065 --> 04:04:31,769
NOT UNEXPECTED.

6153
04:04:31,769 --> 04:04:36,140
THE MAJOR DISEASES REST

6154
04:04:36,140 --> 04:04:37,909
GASTROINTESTINAL, GASTROURINARY,

6155
04:04:37,909 --> 04:04:39,978
INTESTINAL, MAJOR SITES FOR

6156
04:04:39,978 --> 04:04:40,311
ACCRUAL.

6157
04:04:40,311 --> 04:04:42,146
NEXT SLIDE.

6158
04:04:42,146 --> 04:04:44,415
WHAT ABOUT DEMOGRAPHIC OVERVIEW?

6159
04:04:44,415 --> 04:04:50,154
WELL, WE HAVE 68% WHITE RACE,

6160
04:04:50,154 --> 04:04:54,659
25% ARE NON-WHITE, AND/OR

6161
04:04:54,659 --> 04:04:55,560
HISPANIC/LATINO IN ETHNICITY.

6162
04:04:55,560 --> 04:05:00,265
I WOULD LIKE TO POINT OUT THAT

6163
04:05:00,265 --> 04:05:04,102
AS A SIGNIFICANT CONTRAST WITH

6164
04:05:04,102 --> 04:05:06,070
OUR PHARMA COLLEAGUES OVER 36%

6165
04:05:06,070 --> 04:05:08,373
OF OUR PATIENTS ARE AGE 65 AND

6166
04:05:08,373 --> 04:05:09,240
OLDER, SOMETHING YOU WOULD NOT

6167
04:05:09,240 --> 04:05:13,611
EXPECT TO SEE IN A PHARMA TRIAL.

6168
04:05:13,611 --> 04:05:14,612
APPROXIMATELY 16% OF PATIENTS

6169
04:05:14,612 --> 04:05:19,083
ENROLLED ARE FROM RURAL AREAS.

6170
04:05:19,083 --> 04:05:19,751
NEXT SLIDE.

6171
04:05:19,751 --> 04:05:24,389
LET'S  GET TO THE NITTY-GRITTY.

6172
04:05:24,389 --> 04:05:26,357
MIDDLE GRAPH, MIDDLE PORTION OF

6173
04:05:26,357 --> 04:05:29,560
THE TABLE, YOU SEE ABILITY

6174
04:05:29,560 --> 04:05:33,564
AVERAGE NUMBERS FOR 60 MONTHS OF

6175
04:05:33,564 --> 04:05:36,968
THE FIRST FIVE-YEAR STUDY PERIOD

6176
04:05:36,968 --> 04:05:41,205
OF THE NEW NCTN FROM MARCH OF

6177
04:05:41,205 --> 04:05:43,741
2014 TO FEBRUARY OF 2019.

6178
04:05:43,741 --> 04:05:47,011
COMPARE THAT TO THE 65 MONTHS OF

6179
04:05:47,011 --> 04:05:49,547
THE ONGOING ACCRUAL FOR SECOND

6180
04:05:49,547 --> 04:05:50,682
PERIOD OF ACCRUAL.

6181
04:05:50,682 --> 04:05:53,818
I THINK IN MY OPINION AT LEAST

6182
04:05:53,818 --> 04:05:56,454
THE MAINTENANCE OF THE NUMBER OF

6183
04:05:56,454 --> 04:05:59,424
CONCEPTS THAT WERE APPROVED AND

6184
04:05:59,424 --> 04:06:00,725
TRIALS ACTIVATED GIVEN THE

6185
04:06:00,725 --> 04:06:02,827
PANDEMIC IS REALLY QUITE

6186
04:06:02,827 --> 04:06:05,863
EXTRAORDINARY AND A TESTAMENT TO

6187
04:06:05,863 --> 04:06:07,298
ALL OF OUR INVESTIGATORS.

6188
04:06:07,298 --> 04:06:08,733
LOOK AT THE ACTUAL NUMBERS.

6189
04:06:08,733 --> 04:06:13,004
I THINK A LARGE PART OF THE DROP

6190
04:06:13,004 --> 04:06:14,739
IN SCREENING PATIENTS WAS

6191
04:06:14,739 --> 04:06:16,708
BECAUSE OF THE CLOSURE OF THE

6192
04:06:16,708 --> 04:06:19,911
MATCH TRIAL AND PEDIATRIC MATCH

6193
04:06:19,911 --> 04:06:20,111
TRIAL.

6194
04:06:20,111 --> 04:06:23,614
WITH RESPECT TO ACTUAL

6195
04:06:23,614 --> 04:06:26,351
INTERVENTION ACCRUALS, ABOUT WE

6196
04:06:26,351 --> 04:06:29,287
ESTIMATE 10 TO 11% OF THAT DROP

6197
04:06:29,287 --> 04:06:30,922
WAS DIRECTLY RELATED TO THE

6198
04:06:30,922 --> 04:06:33,558
COVID-19 PANDEMIC DATA WHICH I

6199
04:06:33,558 --> 04:06:33,958
SHOWED PREVIOUSLY.

6200
04:06:33,958 --> 04:06:36,227
NEXT SLIDE.

6201
04:06:36,227 --> 04:06:40,131
I'D LIKE TO TAKE THIS CHANCE TO

6202
04:06:40,131 --> 04:06:42,533
BRIEFLY HIGHLIGHT JUST TWO OF

6203
04:06:42,533 --> 04:06:45,269
THE QUITE REMARKABLE

6204
04:06:45,269 --> 04:06:47,472
ACHIEVEMENTS OF THE NCTN.

6205
04:06:47,472 --> 04:06:51,209
AS OUTLINED IN THE NEW ENGLAND

6206
04:06:51,209 --> 04:06:54,679
JOURNAL, IN 2023, ENERGY GY 018

6207
04:06:54,679 --> 04:06:57,815
A RANDOMIZED TRIAL THAT WAS

6208
04:06:57,815 --> 04:06:58,616
PLACEBO CONTROLLED WHETHER OR

6209
04:06:58,616 --> 04:07:01,252
NOT THE ADDITION OF

6210
04:07:01,252 --> 04:07:11,095
PEMBROLIZUMAB STANDARD OF CARE

6211
04:07:11,095 --> 04:07:18,970
PACLOTAXOL, MADE A DIFFERENCE IN

6212
04:07:18,970 --> 04:07:19,670
PROGRESSION-FREE SURVIVAL.

6213
04:07:19,670 --> 04:07:21,272
REGRESSION FREE SURVIVAL, THE

6214
04:07:21,272 --> 04:07:25,443
DATA FROM THIS TRIAL WAS USED TO

6215
04:07:25,443 --> 04:07:27,211
OBTAIN FDA APPROVAL ON JUNE 17

6216
04:07:27,211 --> 04:07:30,948
OF THIS YEAR FOR THE USE OF

6217
04:07:30,948 --> 04:07:31,716
PEMBROLIZUMAB IN ENDOMETRIAL

6218
04:07:31,716 --> 04:07:33,684
CANCER, A MAJOR ACHIEVEMENT FOR

6219
04:07:33,684 --> 04:07:37,321
THE NCTN.

6220
04:07:37,321 --> 04:07:38,089
NEXT SLIDE.

6221
04:07:38,089 --> 04:07:41,225
ALSO WITH RESPECT TO THE CONDUCT

6222
04:07:41,225 --> 04:07:43,528
OF COLLABORATIVE TRIALS IN

6223
04:07:43,528 --> 04:07:46,597
SPECIAL POPULATIONS, HATS OFF TO

6224
04:07:46,597 --> 04:07:48,466
THE SOUTHWEST ONCOLOGY FOR

6225
04:07:48,466 --> 04:07:52,136
INITIATING A TRIAL THAT WAS

6226
04:07:52,136 --> 04:07:53,938
NCTN-WIDE TO EVALUATE WHETHER OR

6227
04:07:53,938 --> 04:08:01,279
NOT ADDITION OF IMMUNOTHERAPY IN

6228
04:08:01,279 --> 04:08:04,015
THIS CASE NIVULOMAB FOR

6229
04:08:04,015 --> 04:08:09,887
HODGKIN'S DISEASE INCLUDING A

6230
04:08:09,887 --> 04:08:11,556
COHORT AGE 12-17, 24% OF THE

6231
04:08:11,556 --> 04:08:13,057
PATIENT POPULATION, ALMOST A

6232
04:08:13,057 --> 04:08:14,592
THOUSAND PATIENTS.

6233
04:08:14,592 --> 04:08:17,462
WHAT COULD MAKE A DIFFERENCE IN

6234
04:08:17,462 --> 04:08:19,330
TREATMENT OF THIS CLASSICAL

6235
04:08:19,330 --> 04:08:21,933
DISEASE FOR WHICH ONLY MAJOR

6236
04:08:21,933 --> 04:08:25,002
CHANGES BECAUSE OF THE EFFECT OF

6237
04:08:25,002 --> 04:08:27,505
CHEMOTHERAPY CAN BE DISCERNED.

6238
04:08:27,505 --> 04:08:33,010
I'M DELIGHTED TO REMIND YOU THAT

6239
04:08:33,010 --> 04:08:38,883
THESE RESULTS WERE PRESENTED AT

6240
04:08:38,883 --> 04:08:43,788
2023 ASCO, THE SURVIVAL OF

6241
04:08:43,788 --> 04:08:46,557
NIVOLUMAB HAD MAJOR EFFECT, IN

6242
04:08:46,557 --> 04:08:48,526
THIS POPULATION FEW

6243
04:08:48,526 --> 04:08:52,029
IMMUNE-RELATED ADVERSE EVENTS

6244
04:08:52,029 --> 04:08:53,798
OCCURRED, PERHAPS EVEN MOST

6245
04:08:53,798 --> 04:08:56,100
IMPORTANT LESS THAN 1% OF

6246
04:08:56,100 --> 04:08:56,834
PATIENTS RECEIVED RADIATION

6247
04:08:56,834 --> 04:09:03,508
THERAPY I  WHICH CAN HAVE LONG M

6248
04:09:03,508 --> 04:09:04,942
ADVERSE EVENTS OVER TIME.

6249
04:09:04,942 --> 04:09:07,912
WE BELIEVE THIS IS THE STUDY

6250
04:09:07,912 --> 04:09:10,848
THAT REPRESENTS A KEY STEP FOR

6251
04:09:10,848 --> 04:09:13,251
HARMONIZING PEDIATRIC AND ADULT

6252
04:09:13,251 --> 04:09:15,319
THERAPY, CLASSIC HODGKIN'S

6253
04:09:15,319 --> 04:09:18,189
DISEASE, AND WE THINK ADDITION

6254
04:09:18,189 --> 04:09:21,459
OF NIVOLUMAB IS POISED TO BE A

6255
04:09:21,459 --> 04:09:24,428
NEW STANDARD FOR TREATMENT OF

6256
04:09:24,428 --> 04:09:25,196
ADVANCED STAGE CLASSICAL

6257
04:09:25,196 --> 04:09:25,663
HODGKIN'S DISEASE.

6258
04:09:25,663 --> 04:09:29,133
NEXT SLIDE.

6259
04:09:29,133 --> 04:09:32,737
I COULD NOT MAKE THIS

6260
04:09:32,737 --> 04:09:33,938
PRESENTATION WITHOUT

6261
04:09:33,938 --> 04:09:35,806
HIGHLIGHTING THE INCREDIBLE

6262
04:09:35,806 --> 04:09:39,177
BROAD EFFORT ACROSS THE NCTN

6263
04:09:39,177 --> 04:09:42,246
GROUPS AND LEADERSHIP, NCI

6264
04:09:42,246 --> 04:09:47,285
LEADERSHIP, AND FDA TO MODERNIZE

6265
04:09:47,285 --> 04:09:51,022
TRIAL BASED ON PRELIMINARY STUDY

6266
04:09:51,022 --> 04:09:53,958
BY LUNG MAP GROUP, RANDOMIZED

6267
04:09:53,958 --> 04:10:00,231
SMALL RANDOMIZED PHASE 2 TRIAL

6268
04:10:00,231 --> 04:10:02,166
THAT SUGGESTED COMBINATION WAS

6269
04:10:02,166 --> 04:10:05,570
BETTER THAN INVESTIGATOR CHOICE

6270
04:10:05,570 --> 04:10:10,274
IN SECOND LINE NON-HODGKIN'S

6271
04:10:10,274 --> 04:10:11,709
LYMPHOMA, SECOND LINE THERAPY

6272
04:10:11,709 --> 04:10:13,444
FOR ENHANCED LUNG CANCER, EXCUSE

6273
04:10:13,444 --> 04:10:13,711
ME.

6274
04:10:13,711 --> 04:10:15,980
THIS IS AN AREA THAT NEEDS

6275
04:10:15,980 --> 04:10:17,281
IMPORTANT ADVANCES IN TREATMENT

6276
04:10:17,281 --> 04:10:20,551
SINCE THERE'S SO MANY PATIENTS.

6277
04:10:20,551 --> 04:10:23,187
GOAL WAS TO DEVELOP A STUDY LESS

6278
04:10:23,187 --> 04:10:26,891
BURDENSOME FOR PATIENTS AND

6279
04:10:26,891 --> 04:10:29,193
INVESTIGATORS THAT WOULD ALLOW

6280
04:10:29,193 --> 04:10:31,262
RAPID ACCRUAL AND WAS MUCH MORE

6281
04:10:31,262 --> 04:10:33,931
REPRESENTATIVE, A REAL WORLD

6282
04:10:33,931 --> 04:10:34,999
POPULATION.

6283
04:10:34,999 --> 04:10:37,435
AND PRIMARILY AND IMPORTANTLY,

6284
04:10:37,435 --> 04:10:41,372
TO SERVE AS MODEL FOR FUTURE

6285
04:10:41,372 --> 04:10:42,039
CANCER CLINICAL TRIALS.

6286
04:10:42,039 --> 04:10:45,042
THIS HAS BEEN A MAJOR EVENT IN

6287
04:10:45,042 --> 04:10:47,979
MY DEVELOPMENT AS A CLINICAL

6288
04:10:47,979 --> 04:10:48,546
INVESTIGATOR, BECAUSE IT'S

6289
04:10:48,546 --> 04:10:50,248
REMARKABLE TO SEE ALL OF THESE

6290
04:10:50,248 --> 04:10:51,249
GROUPS CAME TOGETHER, TRIAL

6291
04:10:51,249 --> 04:10:59,991
COULD BE PUT TOGETHER IN LESS

6292
04:10:59,991 --> 04:11:02,760
THAN 200 DAYS, INITIALLY 700

6293
04:11:02,760 --> 04:11:12,837
PATIENTS, THE TRIAL WAS AMENDED

6294
04:11:12,837 --> 04:11:15,473
TO 800.

6295
04:11:15,473 --> 04:11:20,845
ENROLLMENT AS OF 8/3, 2024, WAS

6296
04:11:20,845 --> 04:11:25,549
87% OF THE SAMPLE SIZE

6297
04:11:25,549 --> 04:11:27,952
PROJECTION, LEADING TO IMPORTANT

6298
04:11:27,952 --> 04:11:31,889
OUTCOME WE'LL LEARN QUICKLY AND

6299
04:11:31,889 --> 04:11:35,426
MAY LEAD TO NDA FOR THIS LARGE

6300
04:11:35,426 --> 04:11:37,295
PATIENT POPULATION.

6301
04:11:37,295 --> 04:11:39,330
LASTLY I CANNOT CONCLUDE WITHOUT

6302
04:11:39,330 --> 04:11:41,198
POINTING OUT RESULTS OF THIS

6303
04:11:41,198 --> 04:11:46,470
LANDMARK PAPER BY JOE UNGER AND

6304
04:11:46,470 --> 04:11:48,306
COLLEAGUES, PUBLISHED LAST YEAR,

6305
04:11:48,306 --> 04:11:49,974
2023, IN THE GACO.

6306
04:11:49,974 --> 04:11:56,747
AND THIS STUDY WHICH EVALUATED

6307
04:11:56,747 --> 04:12:00,584
POSITIVE RANDOMIZED TRIALS, SOME

6308
04:12:00,584 --> 04:12:02,987
SINCE 1980, MOSTLY 1990,

6309
04:12:02,987 --> 04:12:06,057
ANALYZED OVER 100,000 PATIENTS,

6310
04:12:06,057 --> 04:12:07,892
DEMONSTRATED THAT THESE STUDIES

6311
04:12:07,892 --> 04:12:12,396
WERE HIGHLY CITED, AND WERE PART

6312
04:12:12,396 --> 04:12:16,767
OF THE CANCER CURE GUIDELINES

6313
04:12:16,767 --> 04:12:18,436
RECOMMENDED AS FAVORABLE

6314
04:12:18,436 --> 04:12:27,745
TREATMENT OVER 90% -- OVER 87%

6315
04:12:27,745 --> 04:12:29,747
OF THOSE STUDIES.

6316
04:12:29,747 --> 04:12:31,449
ESTIMATED TO HAVE AGAIN

6317
04:12:31,449 --> 04:12:33,351
GENERATED 14.2 MILLION LIFE

6318
04:12:33,351 --> 04:12:35,219
YEARS TO PATIENTS WITH CANCER

6319
04:12:35,219 --> 04:12:36,387
THROUGH 2020.

6320
04:12:36,387 --> 04:12:40,124
AT A FEDERAL INVESTMENT COST PER

6321
04:12:40,124 --> 04:12:44,095
LIFE YEAR GAINED THROUGH 2020 OF

6322
04:12:44,095 --> 04:12:44,595
$326.

6323
04:12:44,595 --> 04:12:49,967
I DON'T THINK ANYTHING BETTER

6324
04:12:49,967 --> 04:12:51,402
DEMONSTRATES RETURN ON

6325
04:12:51,402 --> 04:12:52,069
INVESTMENT THAN THESE DATA.

6326
04:12:52,069 --> 04:12:53,604
THANK YOU SO MUCH FOR THE CHANCE

6327
04:12:53,604 --> 04:12:57,508
TO MAKE THIS PRESENTATION.

6328
04:12:57,508 --> 04:13:02,913
[APPLAUSE] 

6329
04:13:02,913 --> 04:13:03,714
>> FANTASTIC!

6330
04:13:03,714 --> 04:13:08,386
THANK YOU SO MUCH, PHIL AND JIM.

6331
04:13:08,386 --> 04:13:10,254
AMAZING WORK ON THE CLINICAL

6332
04:13:10,254 --> 04:13:10,588
TRIALS SIDE.

6333
04:13:10,588 --> 04:13:13,090
WE WANT TO OPEN THE FLOOR FOR

6334
04:13:13,090 --> 04:13:19,997
QUESTIONS FROM THE BOARD.

6335
04:13:19,997 --> 04:13:20,498
KAREN?

6336
04:13:20,498 --> 04:13:21,265
>> SO AMAZING
PRESENTATIONS.

6337
04:13:21,265 --> 04:13:25,136
THANK YOU BOTH VERY MUCH.

6338
04:13:25,136 --> 04:13:28,639
AS A RADIATION ONCOLOGIST WHO

6339
04:13:28,639 --> 04:13:32,710
SPECIALIZES IN HEME, ARTIFACTS

6340
04:13:32,710 --> 04:13:36,180
RELATED TO RADIATION DATES BACK,

6341
04:13:36,180 --> 04:13:37,415
AND WE'VE REVOLUTIONIZED THE WAY

6342
04:13:37,415 --> 04:13:38,516
WE TREAT.

6343
04:13:38,516 --> 04:13:39,350
CAN ADDITIONAL EXPENSE ADDED

6344
04:13:39,350 --> 04:13:43,087
FROM GOING TO SECOND AND THIRD

6345
04:13:43,087 --> 04:13:44,288
LINE SYSTEMIC THERAPIES WHICH

6346
04:13:44,288 --> 04:13:48,692
ADD BURDEN TO PATIENTS IN COST

6347
04:13:48,692 --> 04:13:50,294
AND TOXICITY, I WANT TO POINT

6348
04:13:50,294 --> 04:13:51,095
THAT OUT.

6349
04:13:51,095 --> 04:13:53,464
I DID WANT TO --

6350
04:13:53,464 --> 04:13:54,265
>> EXCEPTION NOTED.

6351
04:13:54,265 --> 04:13:55,366
>> YES, SIR.

6352
04:13:55,366 --> 04:13:55,566
OKAY.

6353
04:13:55,566 --> 04:13:56,667
THANK YOU.

6354
04:13:56,667 --> 04:13:58,869
THANK YOU, SIR.

6355
04:13:58,869 --> 04:14:02,473
SO, I LOVE THAT WE'RE

6356
04:14:02,473 --> 04:14:03,908
HIGHLIGHTING THE ABILITY TO

6357
04:14:03,908 --> 04:14:05,543
REALLY REACH PEOPLE WHERE THEY

6358
04:14:05,543 --> 04:14:05,709
ARE.

6359
04:14:05,709 --> 04:14:06,877
THAT'S THE IMPORTANCE OF THE

6360
04:14:06,877 --> 04:14:07,711
NCORP.

6361
04:14:07,711 --> 04:14:09,713
AND ONE OF THE CHALLENGES AS YOU

6362
04:14:09,713 --> 04:14:12,450
MAY KNOW, PHIL, I ACTUALLY AM ON

6363
04:14:12,450 --> 04:14:14,218
THE EXECUTIVE STEERING COMMITTEE

6364
04:14:14,218 --> 04:14:19,323
FOR WAKE FOREST BASED, 100%

6365
04:14:19,323 --> 04:14:20,558
SYMPTOM MANAGEMENT AND CCDR,

6366
04:14:20,558 --> 04:14:22,860
IT'S WHAT WE DO, BUT PART OF THE

6367
04:14:22,860 --> 04:14:24,161
CHALLENGES COMES FROM LENGTH OF

6368
04:14:24,161 --> 04:14:26,831
TIME TO GET A STUDY THROUGH.

6369
04:14:26,831 --> 04:14:27,998
I DIDN'T -- I DON'T KNOW IF YOU

6370
04:14:27,998 --> 04:14:29,400
TALKED ABOUT THAT.

6371
04:14:29,400 --> 04:14:31,702
CAN YOU TALK ABOUT HOW LONG IT

6372
04:14:31,702 --> 04:14:34,638
TAKES FOR REVIEW PROCESS TO GET

6373
04:14:34,638 --> 04:14:38,576
A STUDY ACTIVATE AND THE OTHER

6374
04:14:38,576 --> 04:14:39,577
IS RESOURCES BECAUSE YOU

6375
04:14:39,577 --> 04:14:42,213
MENTIONED WANTING TO HAVE MORE

6376
04:14:42,213 --> 04:14:42,947
HISPANICS OR INDIVIDUALS NOT

6377
04:14:42,947 --> 04:14:44,515
ENGLISH SPEAKERS BUT THERE'S NOT

6378
04:14:44,515 --> 04:14:45,916
RESOURCES FOR TRANSLATION THAT I

6379
04:14:45,916 --> 04:14:47,585
KNOW OF, THAT'S BEEN A HUGE BEAR

6380
04:14:47,585 --> 04:14:48,886
ARE FOR OUR SITES, IF YOU CAN

6381
04:14:48,886 --> 04:14:50,521
SPEAK TO BOTH OF THOSE THINGS.

6382
04:14:50,521 --> 04:14:55,793
>> SO I CAN'T SPEAK TO THE
TIME

6383
04:14:55,793 --> 04:14:56,794
TO OPEN.

6384
04:14:56,794 --> 04:14:57,761
MAYBE JIM CAN.

6385
04:14:57,761 --> 04:15:01,499
I'LL ASK BRANDI TO SPEAK TO

6386
04:15:01,499 --> 04:15:02,032
THAT.

6387
04:15:02,032 --> 04:15:07,505
WE PAY MORE ATTENTION AND

6388
04:15:07,505 --> 04:15:09,907
INTENTION TO DIVERSE POPULATIONS

6389
04:15:09,907 --> 04:15:12,409
AND NON-ENGLISH SPEAKERS.

6390
04:15:12,409 --> 04:15:15,479
IN TMIST EVERYTHING IS ENGLISH

6391
04:15:15,479 --> 04:15:15,779
AND SPANISH.

6392
04:15:15,779 --> 04:15:17,181
>> AND FRENCH BECAUSE OF
THE

6393
04:15:17,181 --> 04:15:19,450
CANADIAN SITE.

6394
04:15:19,450 --> 04:15:20,651
>> OH, YES, OKAY.

6395
04:15:20,651 --> 04:15:30,494
SO IT'S -- I MEAN, THESE ARE

6396
04:15:30,494 --> 04:15:32,162
TOUGH THINGS.

6397
04:15:32,162 --> 04:15:32,329
JIM?

6398
04:15:32,329 --> 04:15:37,835
>> DR.  DOROSHOW, DO YOU
WANT TO

6399
04:15:37,835 --> 04:15:41,772
COMMENT ON ORWG GUIDELINES?

6400
04:15:41,772 --> 04:15:44,742
>> SOME OF YOU KNOW, NOT
ALL, IN

6401
04:15:44,742 --> 04:15:46,477
THE CONTEXT OF THE 2014 CHANGES

6402
04:15:46,477 --> 04:15:48,879
THAT WE MADE TO THE DEVELOPMENT

6403
04:15:48,879 --> 04:15:53,817
OF THE NCTN WE HAD ANOTHER CTAC

6404
04:15:53,817 --> 04:15:55,786
WORKING GROUP ON OPERATIONAL

6405
04:15:55,786 --> 04:15:59,390
EFFICIENCY WHICH CUT OUR

6406
04:15:59,390 --> 04:16:01,926
TIMELINES AND ESTABLISHED

6407
04:16:01,926 --> 04:16:08,065
GUIDELINES FOR THE TIMELINES.

6408
04:16:08,065 --> 04:16:09,133
WE IMPROVED GUIDELINES DOWN TO

6409
04:16:09,133 --> 04:16:16,707
THE -- I WOULD SAY THEY ARE

6410
04:16:16,707 --> 04:16:18,976
BETTER BUT ARE UNACCEPTABLY

6411
04:16:18,976 --> 04:16:20,411
LONG, ESPECIALLY COMPARED TO

6412
04:16:20,411 --> 04:16:20,778
INDUSTRY TRIALS.

6413
04:16:20,778 --> 04:16:24,014
THERE ARE MANY REASONS.

6414
04:16:24,014 --> 04:16:27,284
PERHAPS I'LL BE INVITED BACK TO

6415
04:16:27,284 --> 04:16:28,519
GIVE YOU AN ESTIMATE, WE

6416
04:16:28,519 --> 04:16:29,687
TRACK -- ONE OF THE THINGS WE

6417
04:16:29,687 --> 04:16:33,290
DID THAT WAS VERY GOOD THAT VERY

6418
04:16:33,290 --> 04:16:37,361
FEW PEOPLE KNOW IN RESPONSE TO

6419
04:16:37,361 --> 04:16:42,600
THE CHANGES RECOMMENDED WE HAVE

6420
04:16:42,600 --> 04:16:45,669
AN ELECTRONIC GANTT CHART WHICH

6421
04:16:45,669 --> 04:16:50,174
CHARACTERIZEs FOR EVERY TRIAL

6422
04:16:50,174 --> 04:16:52,910
IN NCTN AND ECTN VARIOUS

6423
04:16:52,910 --> 04:16:57,214
COMPONENTS OF TIME, DOESN'T

6424
04:16:57,214 --> 04:16:58,415
START IN COOPERATIVE GROUPS, IT

6425
04:16:58,415 --> 04:17:00,417
STARTS WHEN LETTERS OF INTENT

6426
04:17:00,417 --> 04:17:02,686
ARE SUBMITTED TO NCI.

6427
04:17:02,686 --> 04:17:03,988
PREVIOUS TIMEFRAMES ARE ALSO TOO

6428
04:17:03,988 --> 04:17:05,756
LONG BUT WE DON'T TRACK THOSE.

6429
04:17:05,756 --> 04:17:11,562
WHAT WE DO TRACK I CAN TELL YOU

6430
04:17:11,562 --> 04:17:13,297
IS THAT ONE OF THE MAJOR

6431
04:17:13,297 --> 04:17:17,034
COMPONENTS THAT WE FOUND THAT

6432
04:17:17,034 --> 04:17:18,669
ACTUALLY -- TWO THINGS HAVE SET

6433
04:17:18,669 --> 04:17:19,336
IT BACK.

6434
04:17:19,336 --> 04:17:22,072
ONE CONTINUES TO BE A PROBLEM.

6435
04:17:22,072 --> 04:17:25,576
TWO THINGS THAT SET US BACK WERE

6436
04:17:25,576 --> 04:17:26,977
OBVIOUSLY THE COVID ENVIRONMENT,

6437
04:17:26,977 --> 04:17:28,612
WHICH A LOT WHICH REALLY

6438
04:17:28,612 --> 04:17:30,948
MANDATED THAT WE MAKE EXCEPTIONS

6439
04:17:30,948 --> 04:17:33,250
TO THE TIMELINE, PEOPLE JUST

6440
04:17:33,250 --> 04:17:35,219
DIDN'T HAVE STAFF TO GET THESE

6441
04:17:35,219 --> 04:17:42,526
STUDIES OUT AND READY. 

6442
04:17:42,526 --> 04:17:45,663
THE SECOND PART OF THAT OVER THE

6443
04:17:45,663 --> 04:17:47,798
LAST COUPLE YEARS THE TIMELINE

6444
04:17:47,798 --> 04:17:51,301
TO GET DRUG COMMITMENTS FROM

6445
04:17:51,301 --> 04:17:54,271
PHARMA IS JUST STRETCHED OUT

6446
04:17:54,271 --> 04:17:56,907
LONGER AND LONGER BECAUSE --

6447
04:17:56,907 --> 04:18:02,913
WELL, I WOULD HAVE TO ONLY

6448
04:18:02,913 --> 04:18:08,752
SPECULATE WHY THAT'S TRUE BUT IT

6449
04:18:08,752 --> 04:18:09,887
IS TRUE.

6450
04:18:09,887 --> 04:18:11,822
>> WHAT ABOUT FOR
NON-TREATMENT

6451
04:18:11,822 --> 04:18:12,056
TRIALS?

6452
04:18:12,056 --> 04:18:14,158
WE'RE SYMPTOM MANAGEMENT, STILL

6453
04:18:14,158 --> 04:18:17,761
TAKING OVER 300 DAYS.

6454
04:18:17,761 --> 04:18:20,698
>> YEAH, SO NCORP ADAPTED
THE

6455
04:18:20,698 --> 04:18:23,233
OEWG GUIDELINES FOR NCORP TRIALS

6456
04:18:23,233 --> 04:18:25,402
IN 2018.

6457
04:18:25,402 --> 04:18:27,604
AND SIMILARLY WE'VE HAD A LOT OF

6458
04:18:27,604 --> 04:18:30,107
ISSUES BECAUSE OF COVID AND

6459
04:18:30,107 --> 04:18:30,374
EXTENSION.

6460
04:18:30,374 --> 04:18:34,478
I WILL SAY THAT RECENTLY

6461
04:18:34,478 --> 04:18:36,046
WE'VE -- WITH RECOMPETITIONS

6462
04:18:36,046 --> 04:18:37,648
COMING UP WE HAVE TAKEN A HARD

6463
04:18:37,648 --> 04:18:42,252
LOOK AT WHAT THOSE ORIGINAL

6464
04:18:42,252 --> 04:18:43,787
GUIDE LINES WERE AND SENT OUT

6465
04:18:43,787 --> 04:18:45,856
LETTERS TO FIGURE OUT WHY SOME

6466
04:18:45,856 --> 04:18:46,724
OF THESE STUDIES HAVE THAT HAVE

6467
04:18:46,724 --> 04:18:54,298
BEEN ON THE BOOKS A WHILE

6468
04:18:54,298 --> 04:18:55,766
HAVEN'T YET BEEN ACTIVATED.

6469
04:18:55,766 --> 04:18:57,901
A LOT HAS TO DO WITH

6470
04:18:57,901 --> 04:18:59,002
CONTRACTING, OR GETTING AGENTS

6471
04:18:59,002 --> 04:19:00,504
READY AND AVAILABLE, THE COMPANY

6472
04:19:00,504 --> 04:19:02,706
THAT WAS GOING TO SUPPLY ISN'T

6473
04:19:02,706 --> 04:19:04,908
GOING TO SUPPLY ANYMORE, OR THEY

6474
04:19:04,908 --> 04:19:06,310
DOUBLED THE PRICE AND NOW CAN'T

6475
04:19:06,310 --> 04:19:07,745
AFFORD THAT VERSION, THEY HAVE

6476
04:19:07,745 --> 04:19:09,813
TO GET A DIFFERENT.

6477
04:19:09,813 --> 04:19:12,783
SO EVERY CLINICAL TRIAL HAS A

6478
04:19:12,783 --> 04:19:12,983
STORY.

6479
04:19:12,983 --> 04:19:14,852
AND WE HAVE TO ADAPT TO MAKE IT

6480
04:19:14,852 --> 04:19:17,154
WORK BUT WE ARE TRYING TO TAKE A

6481
04:19:17,154 --> 04:19:18,789
HARD LOOK AND SHORTEN TIMELINES

6482
04:19:18,789 --> 04:19:19,723
WHERE POSSIBLE.

6483
04:19:19,723 --> 04:19:23,060
I WILL SAY ON THE GRANT SIDE OF

6484
04:19:23,060 --> 04:19:25,896
THINGS WHERE 25% OF NCORP TRIALS

6485
04:19:25,896 --> 04:19:27,998
ARE FUNDED, WE RECENTLY STARTED

6486
04:19:27,998 --> 04:19:30,734
HAVING KICKOFF MEETINGS WHEN WE

6487
04:19:30,734 --> 04:19:35,439
KNOW AN NCCOR GRANT IS GOING TO

6488
04:19:35,439 --> 04:19:36,940
GET FUNDED WITH ASSOCIATION WITH

6489
04:19:36,940 --> 04:19:39,543
R01, WITH THE PROGRAM OFFICER,

6490
04:19:39,543 --> 04:19:41,011
PROJECT SCIENTIST, WITH RESEARCH

6491
04:19:41,011 --> 04:19:42,546
BASE AND WITH THE STUDY P.I. TO

6492
04:19:42,546 --> 04:19:43,847
MAKE SURE EVERYBODY IS ON THE

6493
04:19:43,847 --> 04:19:44,848
SAME PAGE, EVERYBODY KNOW WHAT

6494
04:19:44,848 --> 04:19:47,484
IS THEY ARE SUPPOSED TO DO.

6495
04:19:47,484 --> 04:19:47,785
>> GREAT.

6496
04:19:47,785 --> 04:19:51,021
>> THAT DOESN'T MEAN WE
CAN'T DO

6497
04:19:51,021 --> 04:19:51,922
BETTER, KAREN.

6498
04:19:51,922 --> 04:19:53,390
I THINK MAYBE WE SHOULD -- I

6499
04:19:53,390 --> 04:19:55,893
DON'T KNOW WHETHER IT'S A

6500
04:19:55,893 --> 04:19:57,528
WORKING GROUP BUT WE NEED TO

6501
04:19:57,528 --> 04:20:00,264
TAKE A DEEP DIVE AND LOOK AT

6502
04:20:00,264 --> 04:20:07,271
WHERE WE CAN CUT THE TIME

6503
04:20:07,271 --> 04:20:08,472
BECAUSE IT'S EVERYBODY.

6504
04:20:08,472 --> 04:20:11,108
HOW TO DO BETTER WILL TAKE A

6505
04:20:11,108 --> 04:20:11,975
COLLECTIVE TO SOLVE IT.

6506
04:20:11,975 --> 04:20:13,644
THANK YOU FOR RAISING THAT

6507
04:20:13,644 --> 04:20:14,077
POINT.

6508
04:20:14,077 --> 04:20:15,579
>> WE HAVE TIME FOR TWO
MORE

6509
04:20:15,579 --> 04:20:16,547
QUESTIONS.

6510
04:20:16,547 --> 04:20:24,388
I'M GOING TO GO WITH CHRIS AND

6511
04:20:24,388 --> 04:20:25,055
AJA.

6512
04:20:25,055 --> 04:20:25,355
>> THANKS.

6513
04:20:25,355 --> 04:20:29,893
SORRY I CAN'T BE WITH YOU IN

6514
04:20:29,893 --> 04:20:33,263
PERSON, BEST WISHES FROM ANN

6515
04:20:33,263 --> 04:20:33,797
ARBOR.

6516
04:20:33,797 --> 04:20:34,565
YOUR TEAMS, GRANTEES,

6517
04:20:34,565 --> 04:20:34,932
CONGRATULATIONS.

6518
04:20:34,932 --> 04:20:36,166
IT'S SUCH IMPORTANT WORK AND

6519
04:20:36,166 --> 04:20:38,202
GREAT TO SEE THE WORK.

6520
04:20:38,202 --> 04:20:40,838
I WANT TO DOVETAIL AND ECHO PHIL

6521
04:20:40,838 --> 04:20:43,207
AND KAREN'S DISCUSSION.

6522
04:20:43,207 --> 04:20:45,876
A WORKING GROUP HERE TO

6523
04:20:45,876 --> 04:20:47,945
ACCELERATE THE OPPORTUNITY FROM

6524
04:20:47,945 --> 04:20:51,448
CONCEPT TO RECEIPT OF TRIAL IN  

6525
04:20:51,448 --> 04:20:53,951
COMMUNITY WOULD BE A GREAT WORK

6526
04:20:53,951 --> 04:20:55,586
GROUP TO THINK ABOUT.

6527
04:20:55,586 --> 04:20:57,988
A COMMENT AND QUESTION.

6528
04:20:57,988 --> 04:21:01,291
THE FIRST IS A COMMENT, I THINK

6529
04:21:01,291 --> 04:21:03,694
AS WE THINK ABOUT HISTORICALLY

6530
04:21:03,694 --> 04:21:09,066
WE HAD LABS AND NCORP, THAT MADE

6531
04:21:09,066 --> 04:21:13,871
SENSE FIVE OR TEN YEARS AGO.

6532
04:21:13,871 --> 04:21:14,805
NOW WITH CONSOLIDATIONS,

6533
04:21:14,805 --> 04:21:17,474
ACADEMIC STUDIES AND COMMUNITY

6534
04:21:17,474 --> 04:21:18,709
SITES HAVE BECOME BLURRIER,

6535
04:21:18,709 --> 04:21:21,311
RELATIONSHIPS ARE FAR MORE

6536
04:21:21,311 --> 04:21:22,846
FLEXIBLE AND I WONDER RIGHT NOW

6537
04:21:22,846 --> 04:21:23,981
WE HAVE SOME DISTINCTIONS IN

6538
04:21:23,981 --> 04:21:26,483
TERMS OF WHAT TRIALS CAN OPEN

6539
04:21:26,483 --> 04:21:28,118
WHERE, ET CETERA, THERE MIGHT BE

6540
04:21:28,118 --> 04:21:29,519
CONFUSION ABOUT THAT BUT I

6541
04:21:29,519 --> 04:21:33,690
WONDER IF THERE'S AN OPPORTUNITY

6542
04:21:33,690 --> 04:21:36,526
TO MAKE IT -- MAKE MORE TRIALS

6543
04:21:36,526 --> 04:21:37,794
AVAILABLE ABE CROSS BOTH LABS

6544
04:21:37,794 --> 04:21:38,929
AND NCORP IN THE FUTURE.

6545
04:21:38,929 --> 04:21:40,464
THAT'S A COMMENT.

6546
04:21:40,464 --> 04:21:41,999
THE SECOND POINT, PHIL, YOU

6547
04:21:41,999 --> 04:21:44,201
THINK OF WE ISSUING NCORP, WE

6548
04:21:44,201 --> 04:21:46,703
OFTEN SEE THOSE NUMBERS OF SITES

6549
04:21:46,703 --> 04:21:47,905
IN THE PRESENTATIONS BUT I

6550
04:21:47,905 --> 04:21:51,074
WONDER HOW MANY OF THOSE SITES

6551
04:21:51,074 --> 04:21:52,542
PUT PARTICIPANTS ON A STUDY.

6552
04:21:52,542 --> 04:21:55,812
SO I THINK WE WANT TO GET TO THE

6553
04:21:55,812 --> 04:21:57,547
NEXT STEP NOT JUST COUNTING

6554
04:21:57,547 --> 04:21:58,882
PHYSICAL LOCATION WHERE IS

6555
04:21:58,882 --> 04:22:00,384
PATIENTS MAY RECEIVE CARE BUT

6556
04:22:00,384 --> 04:22:03,787
ACTUALLY HOW MANY SITES GO ON TO

6557
04:22:03,787 --> 04:22:05,422
ACTUALLY OPEN STUDY, ACCRUE

6558
04:22:05,422 --> 04:22:06,890
PATIENTS TO A STUDY, APPROACH

6559
04:22:06,890 --> 04:22:08,158
PATIENTS IN STUDY.

6560
04:22:08,158 --> 04:22:11,528
I HOPE THOSE METRICS CAN BE

6561
04:22:11,528 --> 04:22:13,964
BUILT INTO THE NEXT RFP.

6562
04:22:13,964 --> 04:22:15,499
THANKS VERY MUCH.

6563
04:22:15,499 --> 04:22:16,900
>> I'LL COMMENT THAT THE
OPEN

6564
04:22:16,900 --> 04:22:18,869
BUT NOT ACCRUED IS A LITTLE MORE

6565
04:22:18,869 --> 04:22:22,806
CHALLENGING TO GET AT, AFTER MY

6566
04:22:22,806 --> 04:22:27,411
RECENT -- MY FIRST RPPR  REVIEW

6567
04:22:27,411 --> 04:22:30,814
OF THE NCORP PROGRAM.

6568
04:22:30,814 --> 04:22:32,349
IN MEG MOONEY'S PRESENTATION TO

6569
04:22:32,349 --> 04:22:34,952
THE BOARD WITH NCTN

6570
04:22:34,952 --> 04:22:36,420
RECOMPETITION SHE HAD THE NUMBER

6571
04:22:36,420 --> 04:22:38,388
OF SITES THAT CONTRIBUTED

6572
04:22:38,388 --> 04:22:42,893
PARTICIPANTS FROM NCORP TO

6573
04:22:42,893 --> 04:22:46,396
TREATMENT TRIAL ACCRUAL, 623

6574
04:22:46,396 --> 04:22:47,164
SITES.

6575
04:22:47,164 --> 04:22:48,565
>> ONE LAST QUESTION.

6576
04:22:48,565 --> 04:22:49,766
>> REAL QUICK.

6577
04:22:49,766 --> 04:22:50,867
DR. CASTLE, I WANT TO THANK YOU

6578
04:22:50,867 --> 04:22:52,636
FOR PUTTING THE QUESTIONS FOR US

6579
04:22:52,636 --> 04:22:53,603
AT THE END.

6580
04:22:53,603 --> 04:22:55,372
WHEN WE SIT IN THE BOARD ROOM

6581
04:22:55,372 --> 04:22:56,440
IT'S GREAT TO HAVE PEOPLE THAT

6582
04:22:56,440 --> 04:23:00,844
CAN'T TO HEAR BACK FROM US.

6583
04:23:00,844 --> 04:23:02,479
PART WAS HOW DO WE ENGAGE

6584
04:23:02,479 --> 04:23:02,713
PEOPLE.

6585
04:23:02,713 --> 04:23:04,815
I DIDN'T SEE IN THE PRESENTATION

6586
04:23:04,815 --> 04:23:08,185
WHO IS DOING THE NCORP STUDIES

6587
04:23:08,185 --> 04:23:09,486
FROM DEMOGRAPHIC STANDPOINT.

6588
04:23:09,486 --> 04:23:11,922
ONE WOULD ASSUME THAT NCORP

6589
04:23:11,922 --> 04:23:13,357
INVESTIGATORS MIGHT SKEW MORE

6590
04:23:13,357 --> 04:23:16,626
DIVERSE THAN, SAY, GENERAL NCI

6591
04:23:16,626 --> 04:23:17,627
OR MAYBE NCTN INVESTIGATORS BUT

6592
04:23:17,627 --> 04:23:19,262
I DIDN'T SEE THAT DATA.

6593
04:23:19,262 --> 04:23:21,565
I MAY HAVE MISSED IT.

6594
04:23:21,565 --> 04:23:23,767
I WONDERED IF THAT'S ONE OF THE

6595
04:23:23,767 --> 04:23:24,735
STATED GOALS OF NCORP, USING

6596
04:23:24,735 --> 04:23:27,604
THAT AS A WAY OF INCREASING

6597
04:23:27,604 --> 04:23:30,741
DIVERSITY OF PEOPLE BEING --

6598
04:23:30,741 --> 04:23:31,508
PARTICIPATING IN NCTN, IF THAT

6599
04:23:31,508 --> 04:23:33,143
CAN BE TRACKED AND REPORTED IT

6600
04:23:33,143 --> 04:23:34,678
COULD BE FANTASTIC AND MAY

6601
04:23:34,678 --> 04:23:35,879
FURTHER DRIVE ENGAGEMENT IN

6602
04:23:35,879 --> 04:23:36,113
TRIALS.

6603
04:23:36,113 --> 04:23:39,282
>> YOU'RE SPOT ON.

6604
04:23:39,282 --> 04:23:41,051
WE HAVE 15 MINUTES, AND I WENT

6605
04:23:41,051 --> 04:23:42,786
OVER, BUT IF YOU REALLY WANT

6606
04:23:42,786 --> 04:23:44,221
THOSE DATA WE CAN PRODUCE THOSE.

6607
04:23:44,221 --> 04:23:46,723
I AGREE WITH YOU THAT THE

6608
04:23:46,723 --> 04:23:48,358
DIVERSITY SHOULDN'T JUST BE AT

6609
04:23:48,358 --> 04:23:50,761
THE PATIENT -- THEY GO HAND IN

6610
04:23:50,761 --> 04:23:52,763
HAND, ROUND AND ROUND.

6611
04:23:52,763 --> 04:23:55,032
AND AS KIM AND OTHERS HAVE SAID

6612
04:23:55,032 --> 04:23:57,768
THROUGHOUT THE DAY, WE REALLY

6613
04:23:57,768 --> 04:24:00,504
WANT TO CREATE THIS NEW COHORT

6614
04:24:00,504 --> 04:24:01,405
OF INVESTIGATORS THAT REALLY

6615
04:24:01,405 --> 04:24:02,806
REPRESENT THE PEOPLE WE'RE

6616
04:24:02,806 --> 04:24:04,441
TRYING TO HELP.

6617
04:24:04,441 --> 04:24:06,510
AND I THINK THAT'S WHERE THE

6618
04:24:06,510 --> 04:24:08,678
RUBBER MEETS THE ROAD.

6619
04:24:08,678 --> 04:24:09,913
SO, LOOK FORWARD TO WORKING WITH

6620
04:24:09,913 --> 04:24:10,647
ON YOU THAT.

6621
04:24:10,647 --> 04:24:12,849
WE'LL GET YOU SOME OF THAT DATA

6622
04:24:12,849 --> 04:24:15,385
AND YOU'RE SPOT ON, I AGREE WITH

6623
04:24:15,385 --> 04:24:16,920
YOU.

6624
04:24:16,920 --> 04:24:18,455
>> IT'S A GREAT QUESTION,
AND

6625
04:24:18,455 --> 04:24:20,057
ULTIMATELY WE'VE GOT TO MOVE ON.

6626
04:24:20,057 --> 04:24:21,091
THERE ARE ADDITIONAL THE

6627
04:24:21,091 --> 04:24:22,859
QUESTIONS, I CAN SEE PEOPLE

6628
04:24:22,859 --> 04:24:23,693
LOOKING AT ME.

6629
04:24:23,693 --> 04:24:26,663
WE'VE GOT TO MOVE ON.

6630
04:24:26,663 --> 04:24:28,632
THIS WILL COME BACK AROUND, I'M

6631
04:24:28,632 --> 04:24:28,865
SURE.

6632
04:24:28,865 --> 04:24:31,134
>> YES, I WILL SEE YOU IN
THREE

6633
04:24:31,134 --> 04:24:31,601
MONTHS.

6634
04:24:31,601 --> 04:24:34,304
>> INCREDIBLY IMPORTANT
TOPIC.

6635
04:24:34,304 --> 04:24:36,106
THANK YOU BOTH.

6636
04:24:36,106 --> 04:24:38,241
[APPLAUSE] 

6637
04:24:38,241 --> 04:24:40,043
THE BOARD WILL NOW CONSIDER

6638
04:24:40,043 --> 04:24:44,081
ONGOING AND NEW BUSINESS.

6639
04:24:44,081 --> 04:24:46,917
THERE WERE TWO SUBCOMMITTEE

6640
04:24:46,917 --> 04:24:52,823
MEETINGS LAST EVENING, CHAIRS

6641
04:24:52,823 --> 04:24:56,026
WILL GIVE REPORTS.

6642
04:24:56,026 --> 04:24:58,095
DR. RICHARD BOXER IS FIRST.

6643
04:24:58,095 --> 04:25:00,831
>> WE HAD A MEETING LAST
NIGHT,

6644
04:25:00,831 --> 04:25:02,466
FOR AN HOUR AND 15 MINUTES.

6645
04:25:02,466 --> 04:25:06,103
WE WERE ABLE TO EXTEND IT, AS

6646
04:25:06,103 --> 04:25:07,971
CONVERSATIONS AROUND HERE ALWAYS

6647
04:25:07,971 --> 04:25:08,505
DO.

6648
04:25:08,505 --> 04:25:11,241
AND THAT'S GOOD STUFF BECAUSE

6649
04:25:11,241 --> 04:25:15,278
THE -- WE HAD A ROBUST,

6650
04:25:15,278 --> 04:25:16,947
INCREDIBLY INTERESTING

6651
04:25:16,947 --> 04:25:20,550
CONVERSATION ENGAGING EVERYONE

6652
04:25:20,550 --> 04:25:22,385
WHO WAS IN ATTENDANCE.

6653
04:25:22,385 --> 04:25:25,889
THE IDEA OF THE EXPERIMENTAL

6654
04:25:25,889 --> 04:25:29,392
THERAPEUTICS SUBCOMMITTEE WAS TO

6655
04:25:29,392 --> 04:25:31,294
CONSIDER HOW TO FOSTER

6656
04:25:31,294 --> 04:25:33,163
COLLABORATION AMONG ADVOCACY

6657
04:25:33,163 --> 04:25:34,464
GROUPS, ACADEMIA, PRIVATE

6658
04:25:34,464 --> 04:25:36,533
INDUSTRY, NCI, AND THE FDA.

6659
04:25:36,533 --> 04:25:39,936
WE WERE TRYING TO THINK OF ONE

6660
04:25:39,936 --> 04:25:41,004
DIFFERENT -- DIFFERENT WAYS TO

6661
04:25:41,004 --> 04:25:44,407
COLLABORATE AND TO BRING PEOPLE

6662
04:25:44,407 --> 04:25:46,943
TOGETHER IN ORDER TO FOSTER THE

6663
04:25:46,943 --> 04:25:49,112
KIND OF COLLABORATION AND

6664
04:25:49,112 --> 04:25:51,181
CONVERSATION THAT IS SO

6665
04:25:51,181 --> 04:25:55,452
IMPORTANT TO DO SEVERAL THINGS

6666
04:25:55,452 --> 04:25:58,522
THAT WE LISTED IN THE PREVIOUS

6667
04:25:58,522 --> 04:25:59,823
MEETINGS BUT INVOLVED AND

6668
04:25:59,823 --> 04:26:01,825
MATURED THEM IN THIS MEETING.

6669
04:26:01,825 --> 04:26:06,062
THE CONCEPT TO BRINGING TOGETHER

6670
04:26:06,062 --> 04:26:06,863
LEADERS WHO DISCOVERED,

6671
04:26:06,863 --> 04:26:08,165
DEVELOPED, FINANCED NEW

6672
04:26:08,165 --> 04:26:11,701
TREATMENTS OF CANCER WAS

6673
04:26:11,701 --> 04:26:12,969
FUNDAMENTAL CONCEPT.

6674
04:26:12,969 --> 04:26:15,839
WITH THE NCI DEEP EXPERIENCE AND

6675
04:26:15,839 --> 04:26:20,944
EXPERTISE AND RESOURCES THAT CAN

6676
04:26:20,944 --> 04:26:21,711
ACCELERATE BRINGING NEW

6677
04:26:21,711 --> 04:26:24,247
EXPERIMENTAL TREATMENTS TO

6678
04:26:24,247 --> 04:26:28,418
PATIENTS WHY HAS INDUSTRY THAT

6679
04:26:28,418 --> 04:26:31,354
FUND INDUSTRY NOT REALLY -- NOT

6680
04:26:31,354 --> 04:26:32,522
HAVING GOOD CONVERSATIONS OR

6681
04:26:32,522 --> 04:26:34,424
GETTING INVOLVED IN THE

6682
04:26:34,424 --> 04:26:36,293
INNOVATION AT THE NCI?

6683
04:26:36,293 --> 04:26:39,362
AND FUNDAMENTALLY WE WANTED TO

6684
04:26:39,362 --> 04:26:42,065
TRY TO BUILD RELATIONSHIPS

6685
04:26:42,065 --> 04:26:44,167
BETWEEN INFLUENCE VCs WHO CAN

6686
04:26:44,167 --> 04:26:47,237
BUILD AND FINANCE NEW COMPANIES

6687
04:26:47,237 --> 04:26:48,972
TO DEMYSTIFY THE NCI SO

6688
04:26:48,972 --> 04:26:49,973
INNOVATION CAPITAL AND

6689
04:26:49,973 --> 04:26:53,910
ENTREPRENEURS CAN PARTNER WITH

6690
04:26:53,910 --> 04:26:59,783
THE NCI MORE OFTEN TO CREATE

6691
04:26:59,783 --> 04:27:01,117
DISCOVERY COLLABORATIONS WITH

6692
04:27:01,117 --> 04:27:02,219
INVESTIGATORS, WITH EXAMPLES

6693
04:27:02,219 --> 04:27:07,891
GIVEN, TO IMPROVE ACCESS AND

6694
04:27:07,891 --> 04:27:09,292
DEMOCRATIZE ACCESS TO DISCOVERY

6695
04:27:09,292 --> 04:27:12,262
TOOLS, TO LICENSE PROMISING

6696
04:27:12,262 --> 04:27:14,598
EXPERIMENTAL MEDICINES INTO NEW

6697
04:27:14,598 --> 04:27:17,200
COMPANIES THAT CAN DRIVE

6698
04:27:17,200 --> 04:27:19,169
PRODUCTS FORWARD TO THE

6699
04:27:19,169 --> 04:27:20,837
INTRAMURAL AND EXTRAMURAL

6700
04:27:20,837 --> 04:27:21,371
PROGRAMS.

6701
04:27:21,371 --> 04:27:23,540
IT BROUGHT -- ONE OF THE FIRST

6702
04:27:23,540 --> 04:27:26,176
THINGS WE LEARNED TODAY, THIS

6703
04:27:26,176 --> 04:27:29,579
MORNING, FROM KIM WAS HER FIRST

6704
04:27:29,579 --> 04:27:32,649
QUESTION, WHAT SHE SAYS SHE

6705
04:27:32,649 --> 04:27:34,718
NEEDS TO KNOW WITH THE NEW

6706
04:27:34,718 --> 04:27:36,686
CENTER FOR EXTERNAL AFFAIRS AND

6707
04:27:36,686 --> 04:27:37,787
A FOCUS ON COMMUNICATION.

6708
04:27:37,787 --> 04:27:40,290
WHERE WOULD YOU LIKE TO SEE

6709
04:27:40,290 --> 04:27:40,523
MORE?

6710
04:27:40,523 --> 04:27:43,026
I THINK OUR COMMITTEE IS LOOKING

6711
04:27:43,026 --> 04:27:46,196
TO ANSWER THAT, AT LEAST

6712
04:27:46,196 --> 04:27:47,731
PARTIALLY ANSWER THAT, BY

6713
04:27:47,731 --> 04:27:50,033
INCREASING COMMUNICATION BETWEEN

6714
04:27:50,033 --> 04:27:52,969
ALL THE DIFFERENT PLAYERS

6715
04:27:52,969 --> 04:27:54,938
WHETHER ADVOCACY GROUPS OR

6716
04:27:54,938 --> 04:27:57,040
ACADEMIA AND NCI, BUT VERY

6717
04:27:57,040 --> 04:27:58,642
IMPORTANTLY TO INDUSTRY THAT IS

6718
04:27:58,642 --> 04:28:03,280
FUNDING A LOT OF THE NEW

6719
04:28:03,280 --> 04:28:04,581
EXPERIMENTS THAT BRING CARE AND

6720
04:28:04,581 --> 04:28:07,117
IMPROVED DIAGNOSTICS AS WELL AS

6721
04:28:07,117 --> 04:28:17,560
THERAPEUTICS TO THE CANCER

6722
04:28:19,629 --> 04:28:19,829
PATIENTS.

6723
04:28:19,829 --> 04:28:20,730
ROSE, OUR EXECUTIVE EXPECT,

6724
04:28:20,730 --> 04:28:22,032
POINTED OUT INTEREST IN NEW

6725
04:28:22,032 --> 04:28:24,200
THERAPIES IN THE PUBLIC DOMAIN,

6726
04:28:24,200 --> 04:28:26,303
INDUSTRY INVESTMENT CAN ENABLE

6727
04:28:26,303 --> 04:28:27,370
OPPORTUNITIES IN THE AREA.

6728
04:28:27,370 --> 04:28:30,440
NCI IS INTERESTED IN BETTER

6729
04:28:30,440 --> 04:28:31,441
UNDERSTANDING INTERESTS OF

6730
04:28:31,441 --> 04:28:32,942
INVESTORS AND ENCOURAGING THEM

6731
04:28:32,942 --> 04:28:36,680
TO PROVIDE MORE SUPPORT IN THIS

6732
04:28:36,680 --> 04:28:38,615
SPACE.

6733
04:28:38,615 --> 04:28:39,949
WE'RE FORTUNATE IN HAVING JULIE

6734
04:28:39,949 --> 04:28:42,052
GRANT AS A MEMBER OF THE GRANT

6735
04:28:42,052 --> 04:28:44,621
BECAUSE JULIE HAS AN ENORMOUS

6736
04:28:44,621 --> 04:28:46,623
AMOUNT OF CREDIBILITY WITHIN THE

6737
04:28:46,623 --> 04:28:48,391
VENTURE CAPITAL COMMUNITY BUT

6738
04:28:48,391 --> 04:28:52,529
ALSO IS EXTREMELY INTERESTED IN

6739
04:28:52,529 --> 04:28:57,033
HELPING THE NCI WITH, YOU KNOW,

6740
04:28:57,033 --> 04:29:01,404
EXTERNAL FUNDING AS WELL AS

6741
04:29:01,404 --> 04:29:03,173
EXPERIMENTS, AND SHE SAID IN THE

6742
04:29:03,173 --> 04:29:05,041
PRIVATE SECTOR WE OF THEY LOOK

6743
04:29:05,041 --> 04:29:07,877
AT THINGS IN TERMS OF ADDITIONAL

6744
04:29:07,877 --> 04:29:09,612
THREE ZEROES AFTER THE AMOUNT OF

6745
04:29:09,612 --> 04:29:12,882
MONEY THAT IS OTHERWISE GIVEN BY

6746
04:29:12,882 --> 04:29:13,983
THE NCI.

6747
04:29:13,983 --> 04:29:18,355
SHE POINTED OUT FOR EXAMPLE ONE

6748
04:29:18,355 --> 04:29:19,089
PARTICULAR COMPANY HAS RAISED

6749
04:29:19,089 --> 04:29:23,727
$500 MILLION FOR ONE PRODUCT, AT

6750
04:29:23,727 --> 04:29:25,061
LEAST ESTABLISHING AN AREA

6751
04:29:25,061 --> 04:29:27,430
WITHIN WHAT THEY FOUND TO BE

6752
04:29:27,430 --> 04:29:30,400
PARTICULARLY ADVANTAGEOUS FOR

6753
04:29:30,400 --> 04:29:34,237
THE PATIENT. 

6754
04:29:34,237 --> 04:29:36,506
SO, WHAT WE WANTED TO DO AT THE

6755
04:29:36,506 --> 04:29:38,274
LEVEL OF THE EXPERIMENTAL

6756
04:29:38,274 --> 04:29:41,478
THERAPEUTICS COMMITTEE TO FOSTER

6757
04:29:41,478 --> 04:29:44,748
AN OPPORTUNITY TO BRING TOGETHER

6758
04:29:44,748 --> 04:29:46,816
IN A SMALL WORKSHOP BUT LATER ON

6759
04:29:46,816 --> 04:29:49,052
A MUCH LARGER WORKSHOP BUT

6760
04:29:49,052 --> 04:29:51,221
INITIALLY SMALL WORKSHOP THAT

6761
04:29:51,221 --> 04:29:54,858
COULD ACT IN MANY RESPECTS AS A

6762
04:29:54,858 --> 04:29:58,228
PILOT FOR THE NCI IN GENERAL TO

6763
04:29:58,228 --> 04:30:01,197
BRING TOGETHER AND HAVE

6764
04:30:01,197 --> 04:30:04,601
COMMUNICATION BETWEEN THE

6765
04:30:04,601 --> 04:30:05,702
PRIVATE SECTOR, PARTICULARLY

6766
04:30:05,702 --> 04:30:07,137
VCs THAT FUND THE PRIVATE

6767
04:30:07,137 --> 04:30:09,105
SECTOR AND SENIOR LEVEL PEOPLE

6768
04:30:09,105 --> 04:30:11,274
IN THE NCI.

6769
04:30:11,274 --> 04:30:12,675
FOR EXAMPLE, JULIE MENTIONED

6770
04:30:12,675 --> 04:30:14,110
THAT IN THE CONVERSATION WITH

6771
04:30:14,110 --> 04:30:18,948
ONE SENIOR PERSON IN THE NCI HE

6772
04:30:18,948 --> 04:30:21,017
JUST COULDN'T UNDERSTAND WHY THE

6773
04:30:21,017 --> 04:30:22,886
SMALL COMPANIES THAT WERE

6774
04:30:22,886 --> 04:30:24,854
LOOKING INTO DIFFERENT PRODUCTS

6775
04:30:24,854 --> 04:30:27,891
THAT COULD EVENTUALLY LEAD TO

6776
04:30:27,891 --> 04:30:29,325
HOPEFULLY CARE FOR THE PATIENT

6777
04:30:29,325 --> 04:30:31,394
NEVER EVEN OPENED THEIR E-MAILS.

6778
04:30:31,394 --> 04:30:32,796
THEY NEVER EVEN KNEW WHAT WAS

6779
04:30:32,796 --> 04:30:34,264
GOING ON IN THE NCI AND DIDN'T

6780
04:30:34,264 --> 04:30:38,501
REALLY WANT TO TALK ABOUT IT

6781
04:30:38,501 --> 04:30:43,540
BECAUSE AS JULIE EXPLAINED, AND

6782
04:30:43,540 --> 04:30:44,741
OTHERS PIPED IN, THAT PEOPLE IN

6783
04:30:44,741 --> 04:30:45,842
THE PRIVATE SECTOR DON'T EVEN

6784
04:30:45,842 --> 04:30:48,578
WANT TO CALL THE GOVERNMENT.

6785
04:30:48,578 --> 04:30:52,415
THEY ARE TRAINED NOT TO TALK TO

6786
04:30:52,415 --> 04:30:53,383
THE GOVERNMENT.

6787
04:30:53,383 --> 04:30:56,453
SO THAT THE ACCESS OF

6788
04:30:56,453 --> 04:30:57,554
INFORMATION AND COMMUNICATION IS

6789
04:30:57,554 --> 04:31:02,125
IN DEEP TROUBLE.

6790
04:31:02,125 --> 04:31:04,227
AND THAT REALLY COULD AND DOES

6791
04:31:04,227 --> 04:31:09,899
INHIBIT NEW DISCOVERIES. 

6792
04:31:09,899 --> 04:31:12,168
SO, FINALLY WE THOUGHT THAT BY

6793
04:31:12,168 --> 04:31:14,070
HELPING PEOPLE OUTSIDE THE NCI

6794
04:31:14,070 --> 04:31:16,139
FIND THE FRONT DOOR, BREAKING

6795
04:31:16,139 --> 04:31:19,108
THROUGH FOR DISCOVERY AND

6796
04:31:19,108 --> 04:31:21,411
BREAKING DOWN SILOS, AND FILLING

6797
04:31:21,411 --> 04:31:26,216
THE GAPS THAT VCs HAVE, AND

6798
04:31:26,216 --> 04:31:27,650
ALIGNING THE INCENTIVES OF

6799
04:31:27,650 --> 04:31:30,153
PRIVATE SECTOR AS WELL AS

6800
04:31:30,153 --> 04:31:32,355
NATIONAL CANCER INSTITUTE, BUT

6801
04:31:32,355 --> 04:31:36,192
IN ADDITION TO NOT JUST PRIVATE

6802
04:31:36,192 --> 04:31:37,827
SECTOR BUT INVOLVING PRIVATE

6803
04:31:37,827 --> 04:31:42,432
SECTOR WITH THE FDA AND WITH

6804
04:31:42,432 --> 04:31:43,399
ACADEMIA, AND ADVOCACY GROUPS

6805
04:31:43,399 --> 04:31:45,902
COULD LEAD TO WHAT WE ALL WANT,

6806
04:31:45,902 --> 04:31:52,308
WHICH IS BETTER CARE FOR THE

6807
04:31:52,308 --> 04:31:52,675
CANCER PATIENTS.

6808
04:31:52,675 --> 04:31:53,176
>> THANKS, RICK.

6809
04:31:53,176 --> 04:31:56,212
WE CAN OPEN THE FLOOR FOR

6810
04:31:56,212 --> 04:32:03,119
QUESTIONS.

6811
04:32:03,119 --> 04:32:03,720
ADDITIONAL INSIGHTS FROM OTHER

6812
04:32:03,720 --> 04:32:06,523
MEMBERS OF THE SUBCOMMITTEE?

6813
04:32:06,523 --> 04:32:06,756
ANDREA?

6814
04:32:06,756 --> 04:32:07,857
>> YES, GREAT JOB
SUMMARIZING

6815
04:32:07,857 --> 04:32:11,661
BUT AS FAR AS ACTION ITEMS, KEN,

6816
04:32:11,661 --> 04:32:13,296
WE WANTED TO FIGURE OUT IF THERE

6817
04:32:13,296 --> 04:32:15,365
WAS A WAY TO ESTABLISH QUARTERLY

6818
04:32:15,365 --> 04:32:18,134
SEMINAR OR SOME WAY TO HIGHLIGHT

6819
04:32:18,134 --> 04:32:20,003
PRINCIPAL INVESTIGATOR AND

6820
04:32:20,003 --> 04:32:24,140
PRESENCE OF INDUSTRY AND SO THAT

6821
04:32:24,140 --> 04:32:26,876
THERE COULD BE A DIALOGUE OR NOT

6822
04:32:26,876 --> 04:32:28,711
NECESSARILY EVEN A DIALOGUE BUT

6823
04:32:28,711 --> 04:32:30,480
AN UNDERSTANDING OF WHAT IS AT

6824
04:32:30,480 --> 04:32:32,815
CUTTING EDGE NOW SCIENTIFICALLY

6825
04:32:32,815 --> 04:32:34,651
AND WHAT INDUSTRY IS INTERESTED

6826
04:32:34,651 --> 04:32:37,720
IN SUPPORTING, THAT THAT MIGHT

6827
04:32:37,720 --> 04:32:41,291
BE A WAY TO START THE

6828
04:32:41,291 --> 04:32:42,191
CONVERSATION.

6829
04:32:42,191 --> 04:32:43,059
>> I LIKE THAT.

6830
04:32:43,059 --> 04:32:46,763
I WAS STRUCK WHEN YOU SAID

6831
04:32:46,763 --> 04:32:48,197
PEOPLE IN INDUSTRY MIGHT BE, YOU

6832
04:32:48,197 --> 04:32:50,066
KNOW, NOT JUST LESS INTERESTED

6833
04:32:50,066 --> 04:32:56,205
IN TALKING TO US BUT DISSUADED

6834
04:32:56,205 --> 04:32:57,173
FROM TALKING TO GOVERNMENT.

6835
04:32:57,173 --> 04:32:58,541
WHERE THERE ARE OPPORTUNITIES TO

6836
04:32:58,541 --> 04:33:00,043
BREAK THAT WALL DOWN I THINK

6837
04:33:00,043 --> 04:33:03,012
THAT WOULD BE REALLY IMPORTANT.

6838
04:33:03,012 --> 04:33:05,848
I DON'T KNOW IF THAT'S A

6839
04:33:05,848 --> 04:33:10,219
SYMPOSIUM THING OR ANOTHER WAY

6840
04:33:10,219 --> 04:33:13,489
OF CONVENING PEOPLE TO HAVE THE

6841
04:33:13,489 --> 04:33:13,756
DIALOGUE.

6842
04:33:13,756 --> 04:33:20,063
>> COULD JULI SPEAK TO
THAT?

6843
04:33:20,063 --> 04:33:22,031
>> I'LL SAY PERHAPS IT'S

6844
04:33:22,031 --> 04:33:22,565
BUILDING RELATIONSHIPS.

6845
04:33:22,565 --> 04:33:24,801
I THINK IN THE SAME WAY THERE'S

6846
04:33:24,801 --> 04:33:28,871
A LOT OF COMPLIANCE NECESSARY TO

6847
04:33:28,871 --> 04:33:35,211
MAINTAIN  AUTONOMY

6848
04:33:35,211 --> 04:33:36,446
IMPORTANT IN TERMS OF CONFLICT

6849
04:33:36,446 --> 04:33:36,746
OF INTEREST.

6850
04:33:36,746 --> 04:33:42,218
A LOT OF US TRAINED IN

6851
04:33:42,218 --> 04:33:44,354
FOR-PROFIT CENTER STARTED IN

6852
04:33:44,354 --> 04:33:49,025
LABS OR INSTITUTIONS, A FLUED

6853
04:33:49,025 --> 04:33:51,861
SYSTEM BUILD THROUGH

6854
04:33:51,861 --> 04:33:52,428
RELATIONSHIPS.

6855
04:33:52,428 --> 04:33:53,162
MEDICINES APPROVED BY FDA, THEY

6856
04:33:53,162 --> 04:33:54,897
ARE THE SAME PEOPLE.

6857
04:33:54,897 --> 04:33:57,000
AND SO I THINK IT'S WHAT THE

6858
04:33:57,000 --> 04:33:58,201
COMMITTEE IS TALKING ABOUT HOW

6859
04:33:58,201 --> 04:34:02,038
DO WE FIND THE RIGHT NEXUS TO

6860
04:34:02,038 --> 04:34:04,207
BUILD RELATIONSHIPS THAT ARE

6861
04:34:04,207 --> 04:34:06,609
APPROPRIATE, WITHIN THE CONFINES

6862
04:34:06,609 --> 04:34:08,244
OF GUIDANCE, ALSO ALLOW THE

6863
04:34:08,244 --> 04:34:09,145
REALLY EXCEPTIONAL KNOWLEDGE

6864
04:34:09,145 --> 04:34:10,980
WITHIN THE NCI TO PERMEATE OUT

6865
04:34:10,980 --> 04:34:14,050
INTO THE PRIVATE SECTOR AND VICE

6866
04:34:14,050 --> 04:34:15,385
VERSA WHERE APPROPRIATE.

6867
04:34:15,385 --> 04:34:17,453
THAT CONVERSATION WAS PART OF

6868
04:34:17,453 --> 04:34:18,988
WHAT WE WERE TALKING ABOUT AT

6869
04:34:18,988 --> 04:34:20,990
THE COMMITTEE.

6870
04:34:20,990 --> 04:34:22,425
AND WE BELIEVE IT'S INCREDIBLY

6871
04:34:22,425 --> 04:34:26,796
IMPORTANT FOR THE NCI AND NCB TO

6872
04:34:26,796 --> 04:34:28,765
DO THIS APPROPRIATELY AND WE

6873
04:34:28,765 --> 04:34:30,867
ALSO KNOW THAT IT'S IMPORTANT TO

6874
04:34:30,867 --> 04:34:32,769
REALLY FIND THE RIGHT SUBSTANCE

6875
04:34:32,769 --> 04:34:34,370
OF THOSE CONVERSATIONS THAT ARE

6876
04:34:34,370 --> 04:34:36,205
ABOUT ADVANCING THE SCIENCE AND

6877
04:34:36,205 --> 04:34:38,074
CLINICAL CARE AND NEW MEDICINES

6878
04:34:38,074 --> 04:34:39,909
UNDER THE COMMITTEE OF EMERGING

6879
04:34:39,909 --> 04:34:41,811
THERAPEUTICS WHICH COULD BE A

6880
04:34:41,811 --> 04:34:43,346
GREAT NEXUS OF THESE INVESTORS

6881
04:34:43,346 --> 04:34:46,516
THAT FUND NEW THERAPIES THROUGH

6882
04:34:46,516 --> 04:34:47,016
START-UPS.

6883
04:34:47,016 --> 04:34:48,051
AND THE INVESTIGATORS WHO HELP

6884
04:34:48,051 --> 04:34:50,687
DRIVE TRIALS THROUGH THE TRIAL

6885
04:34:50,687 --> 04:34:54,123
NETWORKS THAT WERE SO

6886
04:34:54,123 --> 04:34:54,824
ARTICULATELY DESCRIBED.

6887
04:34:54,824 --> 04:34:56,592
A LOT OF SUBSTRATE COULD BE

6888
04:34:56,592 --> 04:34:58,227
BUILT THROUGH THOSE

6889
04:34:58,227 --> 04:34:58,895
RELATIONSHIPS AND HOPEFULLY

6890
04:34:58,895 --> 04:35:00,196
BRING BETTER MEDICINES TO

6891
04:35:00,196 --> 04:35:03,032
PATIENTS FASTER. 

6892
04:35:03,032 --> 04:35:04,267
SO, YEAH, IT'S BRINGING PEOPLE

6893
04:35:04,267 --> 04:35:05,568
TOGETHER TO BUILD RELATIONSHIPS

6894
04:35:05,568 --> 04:35:07,637
>> ONE OTHER THING THAT
WAS

6895
04:35:07,637 --> 04:35:10,740
SUGGESTED, AND THAT IS THAT

6896
04:35:10,740 --> 04:35:11,607
INVESTIGATORS DON'T HAVE A

6897
04:35:11,607 --> 04:35:14,877
FUNDAMENTAL KNOWLEDGE OF HOW TO

6898
04:35:14,877 --> 04:35:16,979
BRING THEIR PRODUCT, THEIR

6899
04:35:16,979 --> 04:35:18,281
DISCOVERY, TO MARKET.

6900
04:35:18,281 --> 04:35:20,917
AND IT'S A CULTURAL CHANGE.

6901
04:35:20,917 --> 04:35:22,985
AND SO IT WAS SUGGESTED THAT

6902
04:35:22,985 --> 04:35:26,055
WOULDN'T IT BE A GOOD IDEA TO

6903
04:35:26,055 --> 04:35:28,458
HAVE AN OPEN FORUM OR

6904
04:35:28,458 --> 04:35:30,660
ROUNDTABLE, MAYBE EVEN ONE

6905
04:35:30,660 --> 04:35:32,662
PERSON, BUT HAVING PREVIOUS NCI

6906
04:35:32,662 --> 04:35:36,999
DIRECTOR, FOR EXAMPLE DR.

6907
04:35:36,999 --> 04:35:38,167
SHARPLESS, OR MAYBE RICK, WHO

6908
04:35:38,167 --> 04:35:40,336
HAS BEEN AWAY FOR A WHILE, BUT

6909
04:35:40,336 --> 04:35:42,371
IN THE PRIVATE SECTOR, TO BE

6910
04:35:42,371 --> 04:35:45,508
ABLE TO TEACH INVESTIGATORS THE

6911
04:35:45,508 --> 04:35:46,075
INTRAMURAL, EXTRAMURAL, OR

6912
04:35:46,075 --> 04:35:48,911
OTHERS, PERHAPS, BUT IN ANY CASE

6913
04:35:48,911 --> 04:35:51,781
HOW TO DO IT, HOW TO GET FROM

6914
04:35:51,781 --> 04:35:55,451
POINT A, BRILLIANT DISCOVERY, TO

6915
04:35:55,451 --> 04:35:58,387
POINT B, INTO THE PATIENT.

6916
04:35:58,387 --> 04:36:00,156
>> MAY I ASK, I ALSO MAYBE
JUST

6917
04:36:00,156 --> 04:36:01,557
TO RAISE ONE OTHER TOPIC THAT

6918
04:36:01,557 --> 04:36:03,960
WAS RAISED IN THE SUBCOMMITTEE,

6919
04:36:03,960 --> 04:36:06,062
I DO THINK TIES TO THE LAST

6920
04:36:06,062 --> 04:36:06,963
CONVERSATION ABOUT TRIALS.

6921
04:36:06,963 --> 04:36:08,264
I THINK THERE'S A NUMBER OF

6922
04:36:08,264 --> 04:36:11,534
OTHER IDEAS THAT CAME FROM THESE

6923
04:36:11,534 --> 04:36:15,571
EXPERIMENTAL THERAPEUTICS

6924
04:36:15,571 --> 04:36:18,407
COMMITTEE THAT RELATED TO

6925
04:36:18,407 --> 04:36:23,880
CENTERS AND PHARMACEUTICAL

6926
04:36:23,880 --> 04:36:24,647
DISCOVERY, AT VANDERBILT, FOR

6927
04:36:24,647 --> 04:36:26,749
EXAMPLE, IS THAT A WAY?

6928
04:36:26,749 --> 04:36:28,718
WE TALKED ABOUT WAYS TO

6929
04:36:28,718 --> 04:36:33,523
ACCELERATE CLINICAL TRIALS, IS

6930
04:36:33,523 --> 04:36:37,493
THERE DUPLICATIVE REVIEWS?

6931
04:36:37,493 --> 04:36:39,862
CAN WE USE SMALL PHARMA, VERY

6932
04:36:39,862 --> 04:36:41,397
SMALL ORGANIZATIONS THAT CAN

6933
04:36:41,397 --> 04:36:44,934
DECIDE WHO TEN ENABLE SOME

6934
04:36:44,934 --> 04:36:46,235
EXPERIMENTATION RAPID PUSH

6935
04:36:46,235 --> 04:36:46,469
FORWARD.

6936
04:36:46,469 --> 04:36:49,071
IT WAS A VERY BROAD CONVERSATION

6937
04:36:49,071 --> 04:36:51,374
ACROSS ALL THE DIFFERENT

6938
04:36:51,374 --> 04:36:52,909
CONSTITUENTS WHICH MAKES ME

6939
04:36:52,909 --> 04:36:54,343
QUITE EXCITED WHAT COULD COME AT

6940
04:36:54,343 --> 04:36:56,746
THIS INTERSECTION OF THE

6941
04:36:56,746 --> 04:36:57,713
EXECUTION OF EXPERIMENTAL

6942
04:36:57,713 --> 04:36:58,815
THERAPEUTICS WITH ALL THESE

6943
04:36:58,815 --> 04:37:01,350
STAKEHOLDERS, IT WAS A GREAT

6944
04:37:01,350 --> 04:37:02,418
CONVERSATION, THANK YOU TO

6945
04:37:02,418 --> 04:37:09,192
EVERYONE FOR ATTENDING. 

6946
04:37:09,192 --> 04:37:11,727
A VERY ROBUST DIALOGUE.

6947
04:37:11,727 --> 04:37:15,531
>> YOU HAD A GREAT IDEA,
ABOUT

6948
04:37:15,531 --> 04:37:18,734
HOW -- FOR CLINICAL TRIALS

6949
04:37:18,734 --> 04:37:21,137
MERGING ACADEMIA AND NCI AS WELL

6950
04:37:21,137 --> 04:37:23,873
AS THE PRIVATE SECTOR BECAUSE OF

6951
04:37:23,873 --> 04:37:27,410
THE COST OR THE PAYMENT.

6952
04:37:27,410 --> 04:37:29,545
>> YEAH, SO THIS YEAR WE
HAD A

6953
04:37:29,545 --> 04:37:30,546
SUBCOMMITTEE MEETING FOR

6954
04:37:30,546 --> 04:37:31,514
CLINICAL INVESTIGATION

6955
04:37:31,514 --> 04:37:32,849
SUBCOMMITTEE AND WE GOT FEEDBACK

6956
04:37:32,849 --> 04:37:35,151
FROM DR. MOONEY WHO SET OUT

6957
04:37:35,151 --> 04:37:39,288
QUESTIONNAIRES, NONE OF THIS WAS

6958
04:37:39,288 --> 04:37:39,589
SURPRISING.

6959
04:37:39,589 --> 04:37:42,058
WE AT THE CANCER CENTERS WERE

6960
04:37:42,058 --> 04:37:43,359
NOT BEING COMPENSATED THAT WOULD

6961
04:37:43,359 --> 04:37:45,127
MATCH WHAT INDUSTRY GIVES US TO

6962
04:37:45,127 --> 04:37:46,863
ENROLL CLINICAL TRIALS AND THIS

6963
04:37:46,863 --> 04:37:48,731
CREATES HUGE HURDLES ESPECIALLY

6964
04:37:48,731 --> 04:37:50,700
IN TODAY'S FUNDING ENVIRONMENT.

6965
04:37:50,700 --> 04:37:52,802
AND JOHN, TO WHAT YOU SAID,

6966
04:37:52,802 --> 04:37:53,569
CLINICAL REVENUE IS NOT

6967
04:37:53,569 --> 04:37:56,305
SUSTAINING US THE WAY IT WAS SO

6968
04:37:56,305 --> 04:38:00,409
THE QUESTION WAS COULD WE

6969
04:38:00,409 --> 04:38:04,413
LEVERAGE THE 20+ YEAR

6970
04:38:04,413 --> 04:38:06,616
INFRASTRUCTURE OF CLINICAL

6971
04:38:06,616 --> 04:38:09,118
TRIALS THROUGH THE ECTCN WITH

6972
04:38:09,118 --> 04:38:10,353
VENTURE CAPITAL AND NEW

6973
04:38:10,353 --> 04:38:11,120
COMPANIES AND BRING THAT

6974
04:38:11,120 --> 04:38:15,258
TOGETHER BEING ABLE TO USE IT AS

6975
04:38:15,258 --> 04:38:16,626
A HIGHWAY, THIS WHOLE STRUCTURE

6976
04:38:16,626 --> 04:38:20,429
THAT EXISTS AS WITH A WAY TO

6977
04:38:20,429 --> 04:38:21,831
SUPPLEMENT THE AMOUNT OF MONEY

6978
04:38:21,831 --> 04:38:23,332
INSTITUTIONS ARE GETTING.

6979
04:38:23,332 --> 04:38:24,500
WE ALSO RECOGNIZE THE TIMELINE

6980
04:38:24,500 --> 04:38:25,801
QUESTION THAT WE JUST BROUGHT

6981
04:38:25,801 --> 04:38:28,070
UP, KAREN JUST BROUGHT UP, IS

6982
04:38:28,070 --> 04:38:30,706
GOING TO BE KEY BECAUSE 300 DAYS

6983
04:38:30,706 --> 04:38:35,511
OR 200 DAYS IS NOT ENOUGH FOR

6984
04:38:35,511 --> 04:38:36,279
INDUSTRY.

6985
04:38:36,279 --> 04:38:36,879
SO IT REQUIRES RECONFIGURATION

6986
04:38:36,879 --> 04:38:39,348
BUT COULD BE A WAY TO LEVERAGE

6987
04:38:39,348 --> 04:38:42,084
ASSETS THAT ONLY THE NCI HAS

6988
04:38:42,084 --> 04:38:43,386
GENERATED OVER DECADES WITH THIS

6989
04:38:43,386 --> 04:38:45,488
NEW WAY OF DOING RESEARCH WHICH

6990
04:38:45,488 --> 04:38:46,923
IS REALLY THE WAY FORWARD

6991
04:38:46,923 --> 04:38:48,157
CONSIDERING HOW MUCH MONEY IS IN

6992
04:38:48,157 --> 04:38:54,163
THE PRIVATE INDUSTRY.

6993
04:38:54,163 --> 04:38:55,431
>> WE DECIDED WE WERE
GOING TO

6994
04:38:55,431 --> 04:38:57,867
WORK IN BETWEEN NOW AND THE

6995
04:38:57,867 --> 04:39:00,836
DECEMBER MEETING AND BRING TO

6996
04:39:00,836 --> 04:39:04,640
THE NCAB FOR APPROVAL, WE HOPE,

6997
04:39:04,640 --> 04:39:07,810
THAT WE WILL HAVE SOME FORM OF

6998
04:39:07,810 --> 04:39:09,345
COMMUNICATION, WORKSHOP, SOME

6999
04:39:09,345 --> 04:39:12,381
KIND OF METHOD BY WHICH WE COULD

7000
04:39:12,381 --> 04:39:13,616
BRING TOGETHER THE GROUPS THAT

7001
04:39:13,616 --> 04:39:19,855
ARE SO ESSENTIAL TO ULTIMATELY

7002
04:39:19,855 --> 04:39:22,258
THE PATIENT.

7003
04:39:22,258 --> 04:39:22,925
>> IT SOUNDS LIKE A
WORKSHOP,

7004
04:39:22,925 --> 04:39:25,428
FIRST OF ALL, TO GET THE RIGHT

7005
04:39:25,428 --> 04:39:27,063
PEOPLE IN THE ROOM, A GOOD

7006
04:39:27,063 --> 04:39:29,031
SAMPLING OF THE RIGHT PEOPLE

7007
04:39:29,031 --> 04:39:30,232
TALKING TO EACH OTHER TO FIGURE

7008
04:39:30,232 --> 04:39:33,936
OUT HOW YOU DO THE KIND OF

7009
04:39:33,936 --> 04:39:34,837
MATCH-MAKING AND THINGS, YOU

7010
04:39:34,837 --> 04:39:42,044
KNOW, THAT PEOPLE ARE EXCITED

7011
04:39:42,044 --> 04:39:42,578
ABOUT.

7012
04:39:42,578 --> 04:39:44,246
>> GREAT DISCUSSION.

7013
04:39:44,246 --> 04:39:46,215
NOW THE NCAB MEMBERS HAVE TO

7014
04:39:46,215 --> 04:39:48,084
VOTE TO ACCEPT THE REPORT FROM

7015
04:39:48,084 --> 04:39:50,152
THE AD HOC SUBCOMMITTEE ON

7016
04:39:50,152 --> 04:39:51,587
EXPERIMENTAL THERAPEUTICS THAT

7017
04:39:51,587 --> 04:39:53,556
WAS JUST PROVIDED BY RICK.

7018
04:39:53,556 --> 04:39:56,292
IS THERE A MOTION?

7019
04:39:56,292 --> 04:39:58,694
A SECOND?

7020
04:39:58,694 --> 04:39:59,895
FURTHER DISCUSSION?

7021
04:39:59,895 --> 04:40:06,268
BEING NONE LET'S VOTE. 

7022
04:40:06,268 --> 04:40:10,039
ANY NAYS?

7023
04:40:10,039 --> 04:40:10,339
ABSTENTIONS?

7024
04:40:10,339 --> 04:40:11,707
IT'S UNANIMOUS.

7025
04:40:11,707 --> 04:40:12,041
OKAY.

7026
04:40:12,041 --> 04:40:14,977
WE'LL MOVE TO THE NEXT

7027
04:40:14,977 --> 04:40:17,813
SUBCOMMITTEE REPORT, BROUGHT BY

7028
04:40:17,813 --> 04:40:20,116
DR. WINKFIELD, WHO CHAIRS AD HOC

7029
04:40:20,116 --> 04:40:22,084
SUBCOMMITTEE ON POPULATION

7030
04:40:22,084 --> 04:40:22,551
SCIENCE, EPIDEMIOLOGY,

7031
04:40:22,551 --> 04:40:23,285
DISPARITIES.

7032
04:40:23,285 --> 04:40:23,486
KAREN?

7033
04:40:23,486 --> 04:40:24,153
>> THANK YOU, JOHN.

7034
04:40:24,153 --> 04:40:26,022
I WANT TO THANK THE MANY FOLKS

7035
04:40:26,022 --> 04:40:26,355
WHO ATTENDED.

7036
04:40:26,355 --> 04:40:28,891
WE HAD A LOT OF THE

7037
04:40:28,891 --> 04:40:29,759
REPRESENTATION, NCI, THAT WAS

7038
04:40:29,759 --> 04:40:31,394
WONDERFUL TO HAVE THEM IN THE

7039
04:40:31,394 --> 04:40:31,727
AUDIENCE.

7040
04:40:31,727 --> 04:40:37,767
ONE OF THE THINGS THAT I TRY TO

7041
04:40:37,767 --> 04:40:38,834
DO IS TO REMIND FOLKS OF THE

7042
04:40:38,834 --> 04:40:40,503
PURPOSE OF THE SUBCOMMITTEE

7043
04:40:40,503 --> 04:40:48,744
REALLY TO HELP  ADVISE, ALSO TO

7044
04:40:48,744 --> 04:40:49,945
EVALUATE NEW POTENTIAL

7045
04:40:49,945 --> 04:40:51,247
APPROACHES, BARRIERS THERE MIGHT

7046
04:40:51,247 --> 04:40:51,414
BE.

7047
04:40:51,414 --> 04:40:54,183
WE'RE TALKING ABOUT NEW TYPES OF

7048
04:40:54,183 --> 04:40:54,683
RESEARCH.

7049
04:40:54,683 --> 04:40:57,386
WE WERE VERY EXCITED AND HONORED

7050
04:40:57,386 --> 04:41:00,423
TO HAVE DR. CHERYL BOYCE GIVE A

7051
04:41:00,423 --> 04:41:01,657
PRESENTATION ON THE ComPASS

7052
04:41:01,657 --> 04:41:03,292
PROGRAM, MANY OF YOU MAY HAVE

7053
04:41:03,292 --> 04:41:05,461
HEARD OF IT, COMMUNITY

7054
04:41:05,461 --> 04:41:09,532
PARTNERSHIPS TO ADVANCE SCIENCE

7055
04:41:09,532 --> 04:41:10,866
FOR SOCIETY, ComPASS PROGRAM,

7056
04:41:10,866 --> 04:41:11,934
FUNDED THROUGH THE COMMON FUND

7057
04:41:11,934 --> 04:41:14,170
WHICH WE HEARD ABOUT EARLIER,

7058
04:41:14,170 --> 04:41:17,506
THE FIRST AWARDS COMING FROM THE

7059
04:41:17,506 --> 04:41:17,940
COMMON FUND.

7060
04:41:17,940 --> 04:41:21,310
YOU KNOW, THE ABILITY TO RETHINK

7061
04:41:21,310 --> 04:41:24,413
HOW WE DO RESEARCH IS AN

7062
04:41:24,413 --> 04:41:25,247
INCREDIBLE OPPORTUNITY TO

7063
04:41:25,247 --> 04:41:26,816
ADVANCE RESEARCH AROUND HEALTH

7064
04:41:26,816 --> 04:41:27,249
EQUITY.

7065
04:41:27,249 --> 04:41:29,318
I SAY THAT BECAUSE THERE'S SOME

7066
04:41:29,318 --> 04:41:33,355
ESTIMATES THAT IF WE INDEED WERE

7067
04:41:33,355 --> 04:41:34,557
TO REDUCE HEALTHCARE

7068
04:41:34,557 --> 04:41:35,224
DISPARITIES, CANCER DISPARITIES,

7069
04:41:35,224 --> 04:41:39,361
WE COULD MEET THE PRESIDENT'S

7070
04:41:39,361 --> 04:41:41,130
MOONSHOT GOAL OF REDUCTION OF

7071
04:41:41,130 --> 04:41:42,898
50% DECREASE IN CANCER DEATHS

7072
04:41:42,898 --> 04:41:45,067
WITHIN 25 YEARS, JUST BY

7073
04:41:45,067 --> 04:41:46,368
REDUCING THE DISPARITIES OR

7074
04:41:46,368 --> 04:41:48,003
ELIMINATING DISPARITIES.

7075
04:41:48,003 --> 04:41:50,005
PART OF THE CHALLENGE WE KNOW

7076
04:41:50,005 --> 04:41:51,540
THERE'S LOTS OF STRUCTURAL

7077
04:41:51,540 --> 04:41:53,175
BARRIERS.

7078
04:41:53,175 --> 04:41:54,143
IF WE HAD UNIVERSAL HEALTH CARE

7079
04:41:54,143 --> 04:41:55,244
COVERAGE MAYBE THAT WOULD BE

7080
04:41:55,244 --> 04:41:56,011
SOMETHING BUT THAT'S NOT WHAT

7081
04:41:56,011 --> 04:41:57,213
THE NCI DOES.

7082
04:41:57,213 --> 04:41:58,180
WE DO RESEARCH.

7083
04:41:58,180 --> 04:41:59,715
PART OF THE CHALLENGE IS HOW DO

7084
04:41:59,715 --> 04:42:02,685
YOU DO RESEARCH ON STRUCTURAL

7085
04:42:02,685 --> 04:42:02,952
BARRIERS?

7086
04:42:02,952 --> 04:42:05,187
AND SO HAVING DR. BOYCE COME WAS

7087
04:42:05,187 --> 04:42:09,024
INCREDIBLE BECAUSE THE ComPASS

7088
04:42:09,024 --> 04:42:10,259
PROGRAM, JUST LAUNCHED ACTUALLY

7089
04:42:10,259 --> 04:42:12,995
TWO YEARS OLD NOW, IS A REAL

7090
04:42:12,995 --> 04:42:16,265
WONDERFUL IDEA TO THINK ABOUT

7091
04:42:16,265 --> 04:42:17,933
REENVISIONING HOW RESEARCH IS

7092
04:42:17,933 --> 04:42:18,167
DONE.

7093
04:42:18,167 --> 04:42:20,136
WHAT THEY DECIDED TO DO WAS

7094
04:42:20,136 --> 04:42:21,670
LEVERAGE PARTNERSHIPS ACROSS

7095
04:42:21,670 --> 04:42:24,306
MULTIPLE SECTORS TO DEVELOP AND

7096
04:42:24,306 --> 04:42:28,244
EVALUATE COMMUNITY-LED HEALTH

7097
04:42:28,244 --> 04:42:28,878
EQUITY STRUCTURES INTERVENTIONS

7098
04:42:28,878 --> 04:42:31,947
TO REDUCE HEALTH DISPARITIES AND

7099
04:42:31,947 --> 04:42:35,251
DEVELOP MODELS FOR COMMUNITY-LED

7100
04:42:35,251 --> 04:42:36,318
AND CROSS-CUTTING STRUCTURAL

7101
04:42:36,318 --> 04:42:37,419
INTERVENTION RESEARCH ACROSS THE

7102
04:42:37,419 --> 04:42:39,488
NIH AND OTHER FEDERAL AGENCIES.

7103
04:42:39,488 --> 04:42:41,790
SO, THIS IS REALLY ALMOST AN

7104
04:42:41,790 --> 04:42:42,892
ALL-OF-GOVERNMENT APPROACH,

7105
04:42:42,892 --> 04:42:43,359
RIGHT?

7106
04:42:43,359 --> 04:42:48,130
THEY DID LEVERAGE THE EXPERTISE,

7107
04:42:48,130 --> 04:42:51,200
COMMUNITY PARTNERS DEVISED FROM

7108
04:42:51,200 --> 04:42:52,601
LOTS OF ORGANIZATIONS INCLUDING

7109
04:42:52,601 --> 04:42:55,271
USDA FOR EXAMPLE, TO SAY WHO ARE

7110
04:42:55,271 --> 04:42:57,239
THE PEOPLE WE NEED AT THE TABLE,

7111
04:42:57,239 --> 04:43:01,944
WHO DO WE NEED TO INVITE TO

7112
04:43:01,944 --> 04:43:03,512
CONSIDER THIS AWARD MECHANISM.

7113
04:43:03,512 --> 04:43:05,247
BEFORE THEY LAUNCHED THIS RFA

7114
04:43:05,247 --> 04:43:07,216
THEY SAID, WELL, LET'S GO TO THE

7115
04:43:07,216 --> 04:43:09,518
COMMUNITIES THAT HAVE BEEN MOST

7116
04:43:09,518 --> 04:43:10,619
DISENFRANCHISED AND ASK WHAT

7117
04:43:10,619 --> 04:43:12,454
THEY THINK IS NEEDED TO HELP

7118
04:43:12,454 --> 04:43:16,292
ADVANCE THE SCIENCE AND RETHINK

7119
04:43:16,292 --> 04:43:17,193
AND REENVISION HOW RESEARCH IS

7120
04:43:17,193 --> 04:43:18,727
DONE IN THIS AREA.

7121
04:43:18,727 --> 04:43:20,696
NIH CONDUCTED EIGHT LISTENING

7122
04:43:20,696 --> 04:43:23,532
SESSIONS IN 2021 TO SOLICIT

7123
04:43:23,532 --> 04:43:24,200
INPUT.

7124
04:43:24,200 --> 04:43:26,168
THEY HAD TRIBAL COMMUNITIES,

7125
04:43:26,168 --> 04:43:26,936
DIFFERENT ORGANIZATIONS,

7126
04:43:26,936 --> 04:43:27,937
ADVOCACY GROUPS WERE THERE.

7127
04:43:27,937 --> 04:43:29,538
THEY REALLY SAID WHAT ARE THE

7128
04:43:29,538 --> 04:43:31,006
THINGS THAT YOU ALL THINK WE

7129
04:43:31,006 --> 04:43:34,476
NEED TO DO DIFFERENTLY IN THIS

7130
04:43:34,476 --> 04:43:34,810
ARENA?

7131
04:43:34,810 --> 04:43:36,879
MANY OF THE DISCUSSION THEMES

7132
04:43:36,879 --> 04:43:38,847
WERE AROUND COMMUNITY OWNERSHIP.

7133
04:43:38,847 --> 04:43:42,151
WE HAD SOME CONVERSATIONS ABOUT

7134
04:43:42,151 --> 04:43:43,352
THE FACT OFTENTIMES RESEARCH IN

7135
04:43:43,352 --> 04:43:47,189
THE IVORY TOWER IS DONE FROM AN

7136
04:43:47,189 --> 04:43:48,157
IVORY TOWER MENTALITY, DONE TO

7137
04:43:48,157 --> 04:43:49,258
THE COMMUNITY INSTEAD OF HEARING

7138
04:43:49,258 --> 04:43:51,227
FROM THE COMMUNITY ABOUT WAYS

7139
04:43:51,227 --> 04:43:53,729
THAT WE CAN ENVISION RESEARCH

7140
04:43:53,729 --> 04:43:55,931
THAT WILL ACTUALLY HAVE AN

7141
04:43:55,931 --> 04:43:57,299
IMPACT ON THE COMMUNITIES WE

7142
04:43:57,299 --> 04:43:57,666
SERVE.

7143
04:43:57,666 --> 04:44:00,402
THIS IS REALLY AN IDEA FLIPPING

7144
04:44:00,402 --> 04:44:03,272
THINGS ON ITS HEAD, WHERE YOU

7145
04:44:03,272 --> 04:44:05,107
REALLY PUT THE POWER IN THE

7146
04:44:05,107 --> 04:44:06,442
HANDS OF THE COMMUNITY,

7147
04:44:06,442 --> 04:44:07,309
COMMUNITY ORGANIZATIONS, IT

7148
04:44:07,309 --> 04:44:08,510
HELPS NOT ONLY WITH BUILDING

7149
04:44:08,510 --> 04:44:10,946
TRUST BECAUSE AS WE KNOW WE HAVE

7150
04:44:10,946 --> 04:44:12,147
INSTITUTIONS, WE KNOW HOW TO

7151
04:44:12,147 --> 04:44:13,449
WRITE GRANTS AND CAN SAY

7152
04:44:13,449 --> 04:44:14,550
WHATEVER, BUT THERE'S LACK OF

7153
04:44:14,550 --> 04:44:15,584
ACCOUNTABILITY IN TERMS OF

7154
04:44:15,584 --> 04:44:16,785
HOLDING PEOPLE'S FEET TO THE

7155
04:44:16,785 --> 04:44:19,121
FIRE SAYING ARE YOU ACTUALLY

7156
04:44:19,121 --> 04:44:19,788
PARTNERING WITH THIS PARTICULAR

7157
04:44:19,788 --> 04:44:21,523
ORGANIZATION, OR IS THIS

7158
04:44:21,523 --> 04:44:23,192
HELICOPTER RESEARCH, WHERE

7159
04:44:23,192 --> 04:44:24,393
YOU'RE JUMPING IN AND JUMPING

7160
04:44:24,393 --> 04:44:27,563
OUT WHEN THE PROJECT IS DONE

7161
04:44:27,563 --> 04:44:30,666
LEADING TO LACK OF

7162
04:44:30,666 --> 04:44:31,433
SUSTAINABILITY.

7163
04:44:31,433 --> 04:44:34,336
THIS BOOTS ON THE GROUND

7164
04:44:34,336 --> 04:44:37,306
APPROACH GAINING INSIGHT FROM

7165
04:44:37,306 --> 04:44:40,342
COMMUNITY FIRST LED TO THIS

7166
04:44:40,342 --> 04:44:42,344
OPPORTUNITY TO REALLY DEVICE

7167
04:44:42,344 --> 04:44:43,212
THIS ComPASS PROGRAM,

7168
04:44:43,212 --> 04:44:45,047
INNOVATIVE APPROACH, THE MONEY

7169
04:44:45,047 --> 04:44:46,148
GOES TO THE COMMUNITY-BASED

7170
04:44:46,148 --> 04:44:48,050
ORGANIZATION, NOT TO THE

7171
04:44:48,050 --> 04:44:48,817
ACADEMIC INSTITUTION.

7172
04:44:48,817 --> 04:44:50,552
IT REALLY FLIPPED THINGS ON ITS

7173
04:44:50,552 --> 04:44:51,854
HEAD AND REALLY WHAT THEY WERE

7174
04:44:51,854 --> 04:44:58,761
ABLE TO DO IS FUND 25 DIFFERENT

7175
04:44:58,761 --> 04:44:59,962
PROGRAMS, ACTUALLY CALLING

7176
04:44:59,962 --> 04:45:02,064
CHESIs, COMMUNITY LED

7177
04:45:02,064 --> 04:45:03,699
INTERVENTION STRUCTURAL, CHESI

7178
04:45:03,699 --> 04:45:04,300
IS THE TERMINOLOGY USED, THERE

7179
04:45:04,300 --> 04:45:07,069
ARE 25 OF THESE.

7180
04:45:07,069 --> 04:45:08,704
IT REALLY IS SPECTACULAR.

7181
04:45:08,704 --> 04:45:10,773
IT WASN'T INTENDED TO DO THIS,

7182
04:45:10,773 --> 04:45:13,175
THEY WERE ABLE TO NOT ONLY BE

7183
04:45:13,175 --> 04:45:14,810
ALL OVER THE COUNTRY SO SHE

7184
04:45:14,810 --> 04:45:17,346
SHOWED A MAP OF WHERE ALL THESE

7185
04:45:17,346 --> 04:45:18,847
CHESIs ARE LOCATED, EVERYWHERE

7186
04:45:18,847 --> 04:45:20,416
IN THE COUNTRY, BUT THEY HAVE

7187
04:45:20,416 --> 04:45:23,218
FIVE TRIBAL COMMUNITIES THAT

7188
04:45:23,218 --> 04:45:24,219
WERE INCLUDED, WHICH WAS

7189
04:45:24,219 --> 04:45:26,188
SPECTACULAR, OFTENTIMES WE KNOW

7190
04:45:26,188 --> 04:45:27,723
OUR AMERICAN INDIAN AND

7191
04:45:27,723 --> 04:45:29,258
INDIGENOUS POPULATIONS GET LEFT

7192
04:45:29,258 --> 04:45:32,194
OUT OF RESEARCH OFTEN BUT FIVE

7193
04:45:32,194 --> 04:45:33,329
TRIBAL INSTITUTIONS APPLYING

7194
04:45:33,329 --> 04:45:34,496
BECAUSE THEY MAY NOT NECESSARILY

7195
04:45:34,496 --> 04:45:37,800
HAVE THE TRUCK TO DO R01-LED

7196
04:45:37,800 --> 04:45:39,101
RESEARCH, THIS WAS A WONDERFUL

7197
04:45:39,101 --> 04:45:40,836
WAY TO OPEN THE DOOR.

7198
04:45:40,836 --> 04:45:42,905
AND IN FACT EVEN THOUGH THEY

7199
04:45:42,905 --> 04:45:45,007
ONLY FUNDED 25 OF THESE, THERE

7200
04:45:45,007 --> 04:45:48,410
WAS LOTS OF INTEREST, THEY HAD

7201
04:45:48,410 --> 04:45:51,880
OVER 25 -- 2400 PEOPLE GET ONTO

7202
04:45:51,880 --> 04:45:55,050
CALLS THAT WERE INTERESTED IN

7203
04:45:55,050 --> 04:45:56,285
THIS PARTICULAR NEW MECHANISM,

7204
04:45:56,285 --> 04:45:58,454
IT SHOWS THERE'S AN OPPORTUNITY

7205
04:45:58,454 --> 04:45:59,922
TO REALLY RETHINK HOW RESEARCH

7206
04:45:59,922 --> 04:46:01,323
IS DONE.

7207
04:46:01,323 --> 04:46:03,392
AGAIN, THE RESEARCH PROJECT, THE

7208
04:46:03,392 --> 04:46:04,026
PROGRAM IS RELATIVELY NEW, ONE

7209
04:46:04,026 --> 04:46:10,165
OF THE THINGS THEY ARE GOING TO

7210
04:46:10,165 --> 04:46:11,633
IMPLEMENT ARE THESE PROGRAMS

7211
04:46:11,633 --> 04:46:13,268
HERAs, HEALTH EQUALITY

7212
04:46:13,268 --> 04:46:13,836
RESEARCH ASSEMBLIES, LARGER

7213
04:46:13,836 --> 04:46:19,842
GROUPS PULLING TOGETHER FOR EACH

7214
04:46:19,842 --> 04:46:20,642
OF THE REGIONS.

7215
04:46:20,642 --> 04:46:23,812
NCI IS GOING TO HELP LEAD, FROM

7216
04:46:23,812 --> 04:46:25,781
WHAT I UNDERSTAND.

7217
04:46:25,781 --> 04:46:26,982
AN ANNOUNCEMENT ON SEPTEMBER 10

7218
04:46:26,982 --> 04:46:29,485
WILL TALK ABOUT THAT BUT, AGAIN,

7219
04:46:29,485 --> 04:46:31,453
OPPORTUNITY TO HAVE INPUT AND

7220
04:46:31,453 --> 04:46:33,422
EXPERTISE TO HELP WITH THE

7221
04:46:33,422 --> 04:46:37,259
PROGRAMMATIC FLOW, TO HELP WITH

7222
04:46:37,259 --> 04:46:37,860
PERHAPS METHODOLOGIC RESEARCH,

7223
04:46:37,860 --> 04:46:39,094
EXPERTISE, AND SO IT'S GOING TO

7224
04:46:39,094 --> 04:46:40,195
BE FASCINATING TO SEE HOW THIS

7225
04:46:40,195 --> 04:46:41,630
IS DONE.

7226
04:46:41,630 --> 04:46:43,165
THIS IS THE 10-YEAR PROGRAM

7227
04:46:43,165 --> 04:46:44,400
THOUGH, RIGHT?

7228
04:46:44,400 --> 04:46:48,003
TWO YEARS FOR PLANNING, WHICH IS

7229
04:46:48,003 --> 04:46:48,437
GREAT. 

7230
04:46:48,437 --> 04:46:53,275
WE HEAR ABOUT UG3, UH3.

7231
04:46:53,275 --> 04:46:56,412
I LOVE MECHANISMS THAT PUT THAT

7232
04:46:56,412 --> 04:46:56,578
IN.

7233
04:46:56,578 --> 04:46:57,413
ComPASS PROGRAM IS ONE OF

7234
04:46:57,413 --> 04:46:57,646
THEM.

7235
04:46:57,646 --> 04:46:59,281
TWO YEARS OF PLANNING FOR THE

7236
04:46:59,281 --> 04:47:02,151
DEEP DIVE, THE NEEDS OF THE

7237
04:47:02,151 --> 04:47:04,653
COMMUNITY, MILESTONES, MORE

7238
04:47:04,653 --> 04:47:07,289
MILESTONES BASED, OTA MECHANISM,

7239
04:47:07,289 --> 04:47:11,560
FOLKS MIGHT REMEMBER THE CEAL

7240
04:47:11,560 --> 04:47:12,961
TEAMS, COMMUNITY ENGAGED

7241
04:47:12,961 --> 04:47:14,096
ALLIANCE AGAINST DISPARITIES

7242
04:47:14,096 --> 04:47:15,664
WHICH ALLOWS FLUIDITY.

7243
04:47:15,664 --> 04:47:17,366
AS THINGS ARISE, YOU DEAL WITH

7244
04:47:17,366 --> 04:47:18,400
COMMUNITY, THINGS MAY CHANGE,

7245
04:47:18,400 --> 04:47:20,402
YOU CAN PIVOT WITHOUT HAVING TO

7246
04:47:20,402 --> 04:47:22,204
GO THROUGH ENTIRE NEW GRANT

7247
04:47:22,204 --> 04:47:23,839
REVIEW PROCESS.

7248
04:47:23,839 --> 04:47:27,142
SO THIS IS A REALLY WONDERFUL

7249
04:47:27,142 --> 04:47:28,110
OPPORTUNITY TO RETHINK RESEARCH.

7250
04:47:28,110 --> 04:47:31,947
ONE THING WE THOUGHT ABOUT AS A

7251
04:47:31,947 --> 04:47:33,615
COMMITTEE, IS THERE A WAY TO

7252
04:47:33,615 --> 04:47:38,520
LEVERAGE THIS INFRASTRUCTURE TO

7253
04:47:38,520 --> 04:47:39,621
ASK CANCER-RELATED QUESTIONS AND

7254
04:47:39,621 --> 04:47:40,823
TO PARTNERS WITH THEM THROUGH

7255
04:47:40,823 --> 04:47:42,124
SUPPLEMENTS OR OTHER WAYS WE

7256
04:47:42,124 --> 04:47:44,526
MIGHT BE ABLE TO LEVERAGE

7257
04:47:44,526 --> 04:47:45,160
AMAZING OPPORTUNITY THAT'S GOING

7258
04:47:45,160 --> 04:47:46,829
TO BE GOING INTO LOOKING AT

7259
04:47:46,829 --> 04:47:47,463
SOCIAL DETERMINANTS OF HEALTH,

7260
04:47:47,463 --> 04:47:49,231
WHICH WE ALSO KNOW IS AN

7261
04:47:49,231 --> 04:47:51,333
NIH-WIDE INITIATIVE, HOW DO YOU

7262
04:47:51,333 --> 04:47:52,868
ACTUALLY, YOU KNOW, MEASURE

7263
04:47:52,868 --> 04:47:56,572
THOSE, RIGHT?

7264
04:47:56,572 --> 04:48:00,509
HOW DO WE DO THE DEEP DIVE AND

7265
04:48:00,509 --> 04:48:01,276
INFLUENCE POLICY?

7266
04:48:01,276 --> 04:48:02,478
THIS ComPASS PROGRAM, PLEASED

7267
04:48:02,478 --> 04:48:07,516
TO HAVE IT PRESENTED, GRATEFUL

7268
04:48:07,516 --> 04:48:09,485
FOR DR. BOYCE AND TEAMS.

7269
04:48:09,485 --> 04:48:11,553
ONE OF THE THINGS IT HELPED US

7270
04:48:11,553 --> 04:48:13,422
SAY, IS THERE ANY WAY WE CAN

7271
04:48:13,422 --> 04:48:15,090
LEVERAGE PREEXISTING OR WHAT'S

7272
04:48:15,090 --> 04:48:17,059
GOING TO BE EXISTING RESOURCE

7273
04:48:17,059 --> 04:48:17,893
POTENTIALLY TO REALLY REENVISION

7274
04:48:17,893 --> 04:48:20,128
WHAT WE'RE DOING IN THE CANCER

7275
04:48:20,128 --> 04:48:20,863
SPACE.

7276
04:48:20,863 --> 04:48:23,499
THERE WAS ONE OF THESE CHESIs

7277
04:48:23,499 --> 04:48:25,801
THAT IS CANCER SPECIFIC,

7278
04:48:25,801 --> 04:48:26,468
ARKANSAS CANCER CONSORTIUM I

7279
04:48:26,468 --> 04:48:28,403
BELIEVE IS THE NAME OF IT.

7280
04:48:28,403 --> 04:48:30,639
ONLY ONE PROJECT IS REALLY

7281
04:48:30,639 --> 04:48:31,974
FOCUSED ON CANCER SPECIFICALLY,

7282
04:48:31,974 --> 04:48:34,142
BUT THAT'S INTENTIONAL.

7283
04:48:34,142 --> 04:48:36,979
IT'S THINKING ABOUT BROAD

7284
04:48:36,979 --> 04:48:37,746
STRUCTURAL BARRIERS.

7285
04:48:37,746 --> 04:48:40,682
TRANSPORTATION IS THE NUMBER ONE

7286
04:48:40,682 --> 04:48:42,050
BARRIER TO CANCER CARE.

7287
04:48:42,050 --> 04:48:45,554
CAN WE LEVERAGE THAT?

7288
04:48:45,554 --> 04:48:47,155
THAT WAS THE BULK.

7289
04:48:47,155 --> 04:48:48,557
WE WANTED TO FOCUS ON NEXT

7290
04:48:48,557 --> 04:48:51,093
STEPS, THINGS TO BRING BACK TO

7291
04:48:51,093 --> 04:48:52,728
THE LARGER GROUP.

7292
04:48:52,728 --> 04:48:53,695
AGAIN, OUR HOMEWORK SIMILAR TO

7293
04:48:53,695 --> 04:48:54,763
THE HOMEWORK FROM THE LAST GROUP

7294
04:48:54,763 --> 04:48:56,431
OF IS REALLY OVER THE NEXT

7295
04:48:56,431 --> 04:48:58,433
COUPLE MONTHS WE'LL BE HAVING

7296
04:48:58,433 --> 04:48:59,601
SOME INTERIM MEETINGS TO REALLY

7297
04:48:59,601 --> 04:49:01,803
START TO DO A DEEP DIVE IN TERMS

7298
04:49:01,803 --> 04:49:03,338
OF THINKING OF WHAT ARE OTHER

7299
04:49:03,338 --> 04:49:05,507
ORGANIZATIONS WE NEED TO THINK

7300
04:49:05,507 --> 04:49:07,042
ABOUT PARTNERING WITH, LEARNING

7301
04:49:07,042 --> 04:49:09,912
FROM, AND HOW DO WE MAKE SURE

7302
04:49:09,912 --> 04:49:12,648
WE'RE PULLING IN THE EXPERTISE

7303
04:49:12,648 --> 04:49:14,616
THAT'S NEEDED TO HELP TO START

7304
04:49:14,616 --> 04:49:16,385
TO THINK ABOUT POPULATION HEALTH

7305
04:49:16,385 --> 04:49:17,920
IN A VERY DIFFERENT WAY.

7306
04:49:17,920 --> 04:49:19,454
SO, I'M GOING TO LEAVE IT AT

7307
04:49:19,454 --> 04:49:19,821
THAT.

7308
04:49:19,821 --> 04:49:21,723
I DIDN'T KNOW IF THE OTHER

7309
04:49:21,723 --> 04:49:22,925
COMMITTEE MEMBERS OR FOLKS OR

7310
04:49:22,925 --> 04:49:23,825
SUBCOMMITTEE MEMBERS OR FOLKS

7311
04:49:23,825 --> 04:49:27,095
THERE WANTED TO ADD ANYTHING TO

7312
04:49:27,095 --> 04:49:28,096
THAT.

7313
04:49:28,096 --> 04:49:31,600
>> ADDITIONAL INSIGHTS
FROM THE

7314
04:49:31,600 --> 04:49:31,934
SUBCOMMITTEE? 

7315
04:49:31,934 --> 04:49:37,973
QUESTIONS FROM THE BOARD? 

7316
04:49:37,973 --> 04:49:45,180
PLEASE USE YOUR MIC. 

7317
04:49:45,180 --> 04:49:45,948
>> VERY COMPREHENSIVE
SUMMARY,

7318
04:49:45,948 --> 04:49:50,552
NOTHING TO ADD TO THAT.

7319
04:49:50,552 --> 04:49:50,819
>> OKAY.

7320
04:49:50,819 --> 04:49:51,186
KIM?

7321
04:49:51,186 --> 04:49:53,055
>> I WANT TO ASK A
QUESTION

7322
04:49:53,055 --> 04:49:56,558
ABOUT THIS ComPASS PROGRAM.

7323
04:49:56,558 --> 04:49:58,493
IT DOES SOUND LIKE IT'S EARLY,

7324
04:49:58,493 --> 04:50:00,028
FROM YOUR SENSE OF HEARING THIS,

7325
04:50:00,028 --> 04:50:02,664
I WASN'T THERE, I WILL LEARN

7326
04:50:02,664 --> 04:50:06,902
MORE SOON, THAT WAS JUST RAMBLE.

7327
04:50:06,902 --> 04:50:08,036
IS THIS THE PERFECT TIME TO

7328
04:50:08,036 --> 04:50:10,339
ALIGN WITH THEM OR IS IT TOO

7329
04:50:10,339 --> 04:50:10,539
EARLY?

7330
04:50:10,539 --> 04:50:11,673
DO THEY KNOW ENOUGH ABOUT WHAT

7331
04:50:11,673 --> 04:50:13,709
THEY ARE DOING FOR US TO

7332
04:50:13,709 --> 04:50:14,276
LEVERAGE EFFECTIVELY?

7333
04:50:14,276 --> 04:50:17,012
>> I DID GET THE SENSE
THEY WERE

7334
04:50:17,012 --> 04:50:18,747
BUILDING THE PLANE AS THEY ARE

7335
04:50:18,747 --> 04:50:18,981
FLYING.

7336
04:50:18,981 --> 04:50:20,716
BUT I WAS INVOLVED WITH NIH CEAL

7337
04:50:20,716 --> 04:50:24,219
TEAMS EARLY ON, WE HAD TO MOVE

7338
04:50:24,219 --> 04:50:24,786
QUICKLY.

7339
04:50:24,786 --> 04:50:25,554
IF SOME WAYS THE CONVERSATION

7340
04:50:25,554 --> 04:50:27,623
WAS TO BE IN LINE WITH THE

7341
04:50:27,623 --> 04:50:30,025
SPIRIT OF THIS AWARD, MAYBE WE

7342
04:50:30,025 --> 04:50:33,962
GO TO THESE GROUPS, HERAs

7343
04:50:33,962 --> 04:50:35,163
FORMED, OR CONSORTIUMS,

7344
04:50:35,163 --> 04:50:37,165
INDIVIDUAL CHESIs, AS YOU'RE

7345
04:50:37,165 --> 04:50:38,233
THINKING ABOUT THE

7346
04:50:38,233 --> 04:50:40,235
INFRASTRUCTURE ISSUE, IS THERE A

7347
04:50:40,235 --> 04:50:41,403
CANCER-RELATED QUESTION YOU CAN

7348
04:50:41,403 --> 04:50:42,604
ASK, RIGHT?

7349
04:50:42,604 --> 04:50:44,673
SOMETIMES PUTTING THE SEED IN

7350
04:50:44,673 --> 04:50:46,675
PEOPLE'S MINDS EARLY IS REALLY

7351
04:50:46,675 --> 04:50:47,009
IMPORTANT.

7352
04:50:47,009 --> 04:50:49,311
SO, YES, I THINK IT IS VERY

7353
04:50:49,311 --> 04:50:49,878
EARLY.

7354
04:50:49,878 --> 04:50:51,179
THERE'S NOT THE INFRASTRUCTURE

7355
04:50:51,179 --> 04:50:52,147
THAT'S BUILT.

7356
04:50:52,147 --> 04:50:54,016
IT'S STILL COMING TO FRUITION.

7357
04:50:54,016 --> 04:50:56,418
BUT I WOULD SAY WHY NOT PUT THAT

7358
04:50:56,418 --> 04:50:58,286
QUESTION IN PEOPLE'S MINDS NOW

7359
04:50:58,286 --> 04:50:59,921
BECAUSE THEY ARE CREATING A

7360
04:50:59,921 --> 04:51:01,423
COMMON DATA MODEL SO PERHAPS WE

7361
04:51:01,423 --> 04:51:03,759
CAN PUT IN A FEW THINGS WE'D

7362
04:51:03,759 --> 04:51:05,527
LIKE TO KNOW, THESE FEW THINGS,

7363
04:51:05,527 --> 04:51:06,928
MAYBE CANCER SCREENING, ET

7364
04:51:06,928 --> 04:51:09,665
CETERA, AND POTENTIALLY USE THIS

7365
04:51:09,665 --> 04:51:10,866
AS OPPORTUNITY TO DO EDUCATION,

7366
04:51:10,866 --> 04:51:14,670
MY THOUGHT.

7367
04:51:14,670 --> 04:51:15,437
WE TALKED ABOUT THAT BECAUSE I

7368
04:51:15,437 --> 04:51:17,105
THINK ONE OF THE THINGS I LOVED

7369
04:51:17,105 --> 04:51:20,942
ABOUT WHAT THEY DID IS USING

7370
04:51:20,942 --> 04:51:23,912
USDA, FOLKS DON'T THINK ABOUT

7371
04:51:23,912 --> 04:51:24,513
FOOD INSECURITY, THINGS WE'VE

7372
04:51:24,513 --> 04:51:27,716
DONE IN THE PAST TO LEVERAGE

7373
04:51:27,716 --> 04:51:29,885
NON-TRADITIONAL PARTNERS TO

7374
04:51:29,885 --> 04:51:32,654
RETHINK CANCER, CANCER RESEARCH,

7375
04:51:32,654 --> 04:51:34,189
CANCER EDUCATION, USING

7376
04:51:34,189 --> 04:51:35,157
PROGRAMS, REALTORS TO PUT

7377
04:51:35,157 --> 04:51:37,459
INFORMATION OUT.

7378
04:51:37,459 --> 04:51:39,628
IT'S AN OPPORTUNITY EARLY ON TO

7379
04:51:39,628 --> 04:51:43,165
START TO KIND OF PUT SOME SEEDS

7380
04:51:43,165 --> 04:51:43,932
INTO THIS PROGRAMMATIC WORK, YOU

7381
04:51:43,932 --> 04:51:46,268
KNOW, WE MIGHT BE ABLE TO GET

7382
04:51:46,268 --> 04:51:49,471
GOOD DATA OUT OF LONG TERM.

7383
04:51:49,471 --> 04:51:49,971
>> FANTASTIC.

7384
04:51:49,971 --> 04:51:51,139
YES, LUIS?

7385
04:51:51,139 --> 04:51:52,874
>> I LIKE THE COMMENT THAT
WE

7386
04:51:52,874 --> 04:51:56,144
COULD CUT CANCER DEATHS BY 50%

7387
04:51:56,144 --> 04:51:57,045
MAYBE BY SCIENCE BUT

7388
04:51:57,045 --> 04:51:58,080
IMPLEMENTATION IN DISPARITIES

7389
04:51:58,080 --> 04:52:00,549
CAN DO THE SAME THING.

7390
04:52:00,549 --> 04:52:02,818
SO IT CUTS THROUGH EVERYTHING TO

7391
04:52:02,818 --> 04:52:04,352
THE PRACTICAL POINT.

7392
04:52:04,352 --> 04:52:05,921
AND DOING BOTH COULD REALLY GET

7393
04:52:05,921 --> 04:52:07,355
US TO THAT GOAL WHICH WOULD BE A

7394
04:52:07,355 --> 04:52:08,090
HUGE SUCCESS.

7395
04:52:08,090 --> 04:52:10,926
>> IT WILL BE HARD TO DO
THE

7396
04:52:10,926 --> 04:52:12,227
FORMER WITHOUT THE LATTER.

7397
04:52:12,227 --> 04:52:16,231
>> WELL, IT'S WHERE YOU
PUT YOUR

7398
04:52:16,231 --> 04:52:17,933
MONEY.

7399
04:52:17,933 --> 04:52:19,601
>> YEAH, YEAH.

7400
04:52:19,601 --> 04:52:20,168
FANTASTIC.

7401
04:52:20,168 --> 04:52:23,038
IF THERE'S NO FURTHER QUESTIONS

7402
04:52:23,038 --> 04:52:25,874
OR DISCUSSION, WE AGAIN NEED TO

7403
04:52:25,874 --> 04:52:28,143
VOTE TO ACCEPT THE REPORT THAT

7404
04:52:28,143 --> 04:52:33,882
WAS PROVIDED BY DR. WINKFIELD

7405
04:52:33,882 --> 04:52:35,317
FROM THE AD HOC SUBCOMMITTEE.

7406
04:52:35,317 --> 04:52:36,518
IS THERE A MOTION?

7407
04:52:36,518 --> 04:52:38,920
>> MOTION TO ACCEPT.

7408
04:52:38,920 --> 04:52:40,455
>> SECOND.

7409
04:52:40,455 --> 04:52:40,989
>> SECOND.

7410
04:52:40,989 --> 04:52:42,290
MOVED AND SECONDED.

7411
04:52:42,290 --> 04:52:43,091
FURTHER DISCUSSION?

7412
04:52:43,091 --> 04:52:44,826
THERE BEING NONE WE NEED TO

7413
04:52:44,826 --> 04:52:47,662
VOTE. 

7414
04:52:47,662 --> 04:52:52,501
ARE THERE ANY NAYs?

7415
04:52:52,501 --> 04:52:54,469
ANY ABSTENTIONS?

7416
04:52:54,469 --> 04:52:55,804
IT'S UNANIMOUS.

7417
04:52:55,804 --> 04:52:57,205
FANTASTIC.

7418
04:52:57,205 --> 04:52:59,307
SO, PRIOR TO ADJOURNING THE OPEN

7419
04:52:59,307 --> 04:53:01,910
SESSION, ARE THERE ANY OTHER

7420
04:53:01,910 --> 04:53:03,345
ISSUES THAT THE BOARD MEMBERS

7421
04:53:03,345 --> 04:53:06,181
WOULD LIKE TO SHARE?

7422
04:53:06,181 --> 04:53:07,149
RICHARD, RICK, YOU MENTIONED

7423
04:53:07,149 --> 04:53:08,049
SOMETHING EARLIER ABOUT

7424
04:53:08,049 --> 04:53:09,451
SOMETHING YOU WANTED TO BRING

7425
04:53:09,451 --> 04:53:09,618
UP.

7426
04:53:09,618 --> 04:53:12,187
>> I WASN'T SURE THIS WAS
THE

7427
04:53:12,187 --> 04:53:12,754
APPROPRIATE TIME.

7428
04:53:12,754 --> 04:53:14,723
I DON'T KNOW IF ANYTHING WILL BE

7429
04:53:14,723 --> 04:53:15,690
THE APPROPRIATE TIME.

7430
04:53:15,690 --> 04:53:17,559
>> THIS IS OPEN SESSION,
JUST

7431
04:53:17,559 --> 04:53:19,628
REMEMBER THAT.

7432
04:53:19,628 --> 04:53:20,061
>> OKAY.

7433
04:53:20,061 --> 04:53:23,799
WELL, THIS HAS TO DO WITH BOARD

7434
04:53:23,799 --> 04:53:24,299
MEETINGS.

7435
04:53:24,299 --> 04:53:25,433
IS THAT APPROPRIATE?

7436
04:53:25,433 --> 04:53:27,736
OKAY, GOOD.

7437
04:53:27,736 --> 04:53:28,737
ALL RIGHT.

7438
04:53:28,737 --> 04:53:31,473
SO, I'VE HAD PREVIOUS EXPERIENCE

7439
04:53:31,473 --> 04:53:33,875
IN THE NCAB, AND THINGS I

7440
04:53:33,875 --> 04:53:37,546
LEARNED IN THOSE 7 1/2 YEARS I'M

7441
04:53:37,546 --> 04:53:39,447
TRYING TO -- I'D LIKE TO BRING

7442
04:53:39,447 --> 04:53:40,582
TO THIS BOARD.

7443
04:53:40,582 --> 04:53:43,084
AND THAT IS THAT WHEN I LOOKED

7444
04:53:43,084 --> 04:53:46,588
AT THE BOARD OF SCIENTIFIC

7445
04:53:46,588 --> 04:53:48,890
ADVISORS CHARTER, THE BOARD OF

7446
04:53:48,890 --> 04:53:51,960
THE SCIENTIFIC ADVISORS

7447
04:53:51,960 --> 04:53:53,395
APPOINTED BY THE NCI DIRECTOR,

7448
04:53:53,395 --> 04:53:55,797
AND OF COURSE IS FOCUSED ON

7449
04:53:55,797 --> 04:53:57,966
RESEARCH PRIORITIES, BUT

7450
04:53:57,966 --> 04:53:59,100
SPECIFICALLY DOES NOT INCLUDE

7451
04:53:59,100 --> 04:54:02,704
DELIBERATION ON MATTERS OF

7452
04:54:02,704 --> 04:54:03,038
PUBLIC POLICY.

7453
04:54:03,038 --> 04:54:04,573
WHEREAS THE NCAB WHICH IS

7454
04:54:04,573 --> 04:54:08,276
APPOINTED OF COURSE BY THE

7455
04:54:08,276 --> 04:54:12,347
PRESIDENT, DOES IN FACT FOCUS ON

7456
04:54:12,347 --> 04:54:13,982
AND MAKES RECOMMENDATIONS

7457
04:54:13,982 --> 04:54:15,717
RESPECTING THE FUTURE DIRECTIONS

7458
04:54:15,717 --> 04:54:18,153
AND PROGRAM AND POLICY EMPHASIS

7459
04:54:18,153 --> 04:54:19,788
OF THE INSTITUTE.

7460
04:54:19,788 --> 04:54:22,090
WHAT I EXPERIENCE TODAY, THIS

7461
04:54:22,090 --> 04:54:25,694
MORNING AND THIS AFTERNOON, WERE

7462
04:54:25,694 --> 04:54:26,995
REALLY OUTSTANDING CONVERSATIONS

7463
04:54:26,995 --> 04:54:30,632
BY VERY INVOLVED AND VERY WELL

7464
04:54:30,632 --> 04:54:33,034
REALLY SMART PEOPLE WHO HAVE A

7465
04:54:33,034 --> 04:54:36,304
LOT TO OFFER THE NCI DIRECTOR.

7466
04:54:36,304 --> 04:54:39,941
AND I THINK IN MY EXPERIENCE,

7467
04:54:39,941 --> 04:54:42,444
PAST EXPERIENCE ANYWAY, THERE

7468
04:54:42,444 --> 04:54:46,147
WAS NEVER A MEETING WITH THE BSA

7469
04:54:46,147 --> 04:54:50,886
AND NCAB WERE MEETING TOGETHER

7470
04:54:50,886 --> 04:54:54,389
BECAUSE THERE REALLY WASN'T

7471
04:54:54,389 --> 04:54:56,458
NECESSARILY A CROSSOVER OF THEIR

7472
04:54:56,458 --> 04:54:56,725
CHARTERS.

7473
04:54:56,725 --> 04:54:59,895
AND SO I WOULD LIKE TO SUGGEST

7474
04:54:59,895 --> 04:55:01,830
TWO THINGS.

7475
04:55:01,830 --> 04:55:04,900
ONE, THAT THE NCAB MEETS LIKE WE

7476
04:55:04,900 --> 04:55:07,435
DID TODAY, WITHOUT THE BSA SO WE

7477
04:55:07,435 --> 04:55:09,938
CAN FOCUS ON POLICY.

7478
04:55:09,938 --> 04:55:13,141
AND, TWO, I WOULD LIKE TO

7479
04:55:13,141 --> 04:55:16,845
SUGGEST THAT WE MEET IN PERSON

7480
04:55:16,845 --> 04:55:18,513
RATHER THAN OVER ZOOM.

7481
04:55:18,513 --> 04:55:20,015
PREVIOUSLY I WAS TOLD, WELL,

7482
04:55:20,015 --> 04:55:22,984
WEATHER IS LOUSY IN THE WINTER.

7483
04:55:22,984 --> 04:55:26,054
BUT QUITE FRANKLY, I'M NOT

7484
04:55:26,054 --> 04:55:28,957
SUGGESTING WE HIT THE IWO JIMA

7485
04:55:28,957 --> 04:55:30,525
BEACHES, WE JUST HAVE TO GET A

7486
04:55:30,525 --> 04:55:31,960
SWEATER ON.

7487
04:55:31,960 --> 04:55:36,197
I THINK THE BENEFIT OF THE

7488
04:55:36,197 --> 04:55:40,235
INTERACTION IN PERSON IS SO MUCH

7489
04:55:40,235 --> 04:55:40,502
STRONGER.

7490
04:55:40,502 --> 04:55:44,072
HERE COMES PAULETTE.

7491
04:55:44,072 --> 04:55:45,840
>> HERE SHE COMES.

7492
04:55:45,840 --> 04:55:47,342
>> IT'S SO MUCH STRONGER.

7493
04:55:47,342 --> 04:55:49,644
>> HERE SHE COMES.

7494
04:55:49,644 --> 04:55:50,845
>> WOULD YOU PLEASE
DISCONNECT?

7495
04:55:50,845 --> 04:55:51,346
[LAUGHTER]

7496
04:55:51,346 --> 04:55:55,550
NO, NO, NO, NO, NO.

7497
04:55:55,550 --> 04:56:00,588
ANYWAY, I JUST THINK -- I HELPED

7498
04:56:00,588 --> 04:56:02,257
CREATE THE TELEMEDICINE 1 YEARS

7499
04:56:02,257 --> 04:56:06,294
AGO FOR TELEDOC, I'M A BIG

7500
04:56:06,294 --> 04:56:10,031
ADVOCATE -- 12 YEARS AGO, BUT

7501
04:56:10,031 --> 04:56:11,766
THERE'S NOTHING LIKE BEING IN

7502
04:56:11,766 --> 04:56:15,437
THE SAME ROOM, BEING ABLE TO

7503
04:56:15,437 --> 04:56:17,906
INTERACT AND HAVE IDEAS PASSED

7504
04:56:17,906 --> 04:56:20,208
BACK AND FORTH, AND HAVE ACTIVE

7505
04:56:20,208 --> 04:56:21,743
DISCUSSIONS, LIKE WHAT HAPPENED

7506
04:56:21,743 --> 04:56:24,245
TODAY, AS WELL AS LAST NIGHT OF

7507
04:56:24,245 --> 04:56:27,082
COURSE FOR OUR SUBCOMMITTEES.

7508
04:56:27,082 --> 04:56:30,352
THERE'S A BIG DIFFERENCE.

7509
04:56:30,352 --> 04:56:34,055
AND THE CHAIR RECOGNIZES

7510
04:56:34,055 --> 04:56:36,524
PAULETTE GRAY. 

7511
04:56:36,524 --> 04:56:41,563
>> RICK, I CAN APPRECIATE
YOUR

7512
04:56:41,563 --> 04:56:42,864
THINKING.

7513
04:56:42,864 --> 04:56:45,500
BUT WE'RE TALKING ABOUT MARCH --

7514
04:56:45,500 --> 04:56:47,035
FEBRUARY AND MARCH.

7515
04:56:47,035 --> 04:56:53,708
THE WEATHER IN THIS AREA CAN BE

7516
04:56:53,708 --> 04:56:55,877
HORRIFIC. 

7517
04:56:55,877 --> 04:56:58,713
I SPECIFICALLY REMEMBER WHEN

7518
04:56:58,713 --> 04:57:03,618
RICKLAUSNER WAS HERE, WE HAD A

7519
04:57:03,618 --> 04:57:04,786
MEETING SCHEDULED IN FEBRUARY.

7520
04:57:04,786 --> 04:57:06,621
HE CALLED ME AT 4:00 THAT

7521
04:57:06,621 --> 04:57:08,390
MORNING, CALLED ME THAT MORNING,

7522
04:57:08,390 --> 04:57:11,426
LATE THAT NIGHT, EARLY THAT

7523
04:57:11,426 --> 04:57:14,929
MORNING, AND I SAID, YES, THE

7524
04:57:14,929 --> 04:57:16,664
MEETING WILL BE HELD.

7525
04:57:16,664 --> 04:57:18,033
IT'S 4:00.

7526
04:57:18,033 --> 04:57:22,470
I'M ON MY WAY TO THE MEETING

7527
04:57:22,470 --> 04:57:23,238
SITE.

7528
04:57:23,238 --> 04:57:25,206
WE HAD ANOTHER ONE, A FEW YEARS

7529
04:57:25,206 --> 04:57:27,075
LATER, WE HAD TO LITERALLY

7530
04:57:27,075 --> 04:57:28,510
CANCEL THE MEETING.

7531
04:57:28,510 --> 04:57:30,145
WE CANCELED MORE MEETINGS IN

7532
04:57:30,145 --> 04:57:36,051
FEBRUARY THAN WE HAVE ANY OTHER

7533
04:57:36,051 --> 04:57:36,484
TIME.

7534
04:57:36,484 --> 04:57:39,554
SO, THAT GIVES YOU THREE TIMES

7535
04:57:39,554 --> 04:57:48,530
TO MEET, FACE TO FACE, AND NCAB

7536
04:57:48,530 --> 04:57:50,498
WITHOUT BSA NUMBERS, THAT'S

7537
04:57:50,498 --> 04:57:54,202
DURING THE MONTH OF JUNE,

7538
04:57:54,202 --> 04:57:58,907
SEPTEMBER, AND DECEMBER.

7539
04:57:58,907 --> 04:58:01,009
IF YOU CANNOT SURVIVE FEBRUARY

7540
04:58:01,009 --> 04:58:06,815
THEN SO BE IT. 

7541
04:58:06,815 --> 04:58:09,517
>> THERE IS MARCH.

7542
04:58:09,517 --> 04:58:10,051
[LAUGHTER]

7543
04:58:10,051 --> 04:58:11,486
>> MARCH IS A STAND-ALONE
BSA

7544
04:58:11,486 --> 04:58:11,820
MEETING.

7545
04:58:11,820 --> 04:58:15,890
SO YOU CAN'T ATTEND THAT ONE

7546
04:58:15,890 --> 04:58:18,359
UNLESS YOU COME AS A LOCAL

7547
04:58:18,359 --> 04:58:27,135
PERSON AND JUST WANT TO OBSERVE 

7548
04:58:27,135 --> 04:58:28,336
>> YOU'RE OFFERING THREE.

7549
04:58:28,336 --> 04:58:30,872
>> THREE IN PERSON ALONE.

7550
04:58:30,872 --> 04:58:33,308
NO, NO, NO.

7551
04:58:33,308 --> 04:58:34,909
NOT ALONE.

7552
04:58:34,909 --> 04:58:42,484
IF YOU WANT TO HAVE ALL OF THE

7553
04:58:42,484 --> 04:58:45,520
NCAB MEMBERS BE ALONE THAT WOULD

7554
04:58:45,520 --> 04:58:48,490
BE FEBRUARY, JUNE, SEPTEMBER,

7555
04:58:48,490 --> 04:58:49,491
AND DECEMBER.

7556
04:58:49,491 --> 04:58:53,428
CURRENTLY, THE JUNE MEETING AND

7557
04:58:53,428 --> 04:59:03,972
THE DECEMBER MEETING IS A JOINT

7558
04:59:04,973 --> 04:59:05,874
MEETING.

7559
04:59:05,874 --> 04:59:10,845
>> WE HAVE TWO ANNUAL NCAB
ONLY?

7560
04:59:10,845 --> 04:59:11,713
>> MEETINGS.

7561
04:59:11,713 --> 04:59:15,650
>> WELL, THAT'S BETTER
THAN -- I

7562
04:59:15,650 --> 04:59:19,187
STILL BELIEVE, YOU HAVEN'T

7563
04:59:19,187 --> 04:59:22,590
CONVINCED ME THAT IN-PERSON

7564
04:59:22,590 --> 04:59:24,792
ALONE MEETINGS WHETHER WE HAVE

7565
04:59:24,792 --> 04:59:28,163
DEEP POLICY CONVERSATIONS LIKE

7566
04:59:28,163 --> 04:59:31,132
THIS IS NOT AS GOOD AS BEING

7567
04:59:31,132 --> 04:59:33,601
WITH BSA, WHICH IS LIKE 25 OR 50

7568
04:59:33,601 --> 04:59:35,403
MORE MEMBERS, WHATEVER IT IS, AT

7569
04:59:35,403 --> 04:59:36,337
THE TABLE.

7570
04:59:36,337 --> 04:59:37,138
>> I'M CONFUSED.

7571
04:59:37,138 --> 04:59:42,377
WHY CAN'T YOU HAVE DEEP POLICY

7572
04:59:42,377 --> 04:59:43,711
CONVERSATIONS OR DISCUSSIONS

7573
04:59:43,711 --> 04:59:45,013
DURING JOINT MEETINGS?

7574
04:59:45,013 --> 04:59:47,715
>> WELL, IT DIDN'T SEEM TO
LEND

7575
04:59:47,715 --> 04:59:52,687
ITSELF WHEN THERE WERE SO MANY

7576
04:59:52,687 --> 04:59:54,756
INDIVIDUALS.

7577
04:59:54,756 --> 04:59:58,459
IT JUST SEEMS LIKE -- THAT MORE

7578
04:59:58,459 --> 05:00:05,366
IS DISCUSSED AND MORE PEOPLE WHO

7579
05:00:05,366 --> 05:00:07,769
ARE POLICY ORIENTED AS OPPOSED

7580
05:00:07,769 --> 05:00:09,137
TO RESEARCH ORIENTED ARE ABLE TO

7581
05:00:09,137 --> 05:00:10,705
HAVE THESE IDEAS PASS AMONG

7582
05:00:10,705 --> 05:00:10,905
THEM.

7583
05:00:10,905 --> 05:00:13,141
I DON'T WANT TO BE THE ONLY

7584
05:00:13,141 --> 05:00:15,310
PERSON TALKING.

7585
05:00:15,310 --> 05:00:15,643
NILO?

7586
05:00:15,643 --> 05:00:20,381
>> THAT'S THE NCI DIRECTOR

7587
05:00:20,381 --> 05:00:21,783
DECISION.

7588
05:00:21,783 --> 05:00:24,752
IF DR. RATHMELL, KIM,

7589
05:00:24,752 --> 05:00:25,753
ASCERTAINED SHE NO LONGER

7590
05:00:25,753 --> 05:00:28,022
PREFERRED TO HAVE JOINT

7591
05:00:28,022 --> 05:00:31,226
MEETINGS, THEN THAT'S FINE.

7592
05:00:31,226 --> 05:00:34,295
THE ONLY THING THAT SHE WILL

7593
05:00:34,295 --> 05:00:39,901
NEED TO DO IN THAT REGARD IS TO

7594
05:00:39,901 --> 05:00:46,140
GIVE SEVEN DIRECTOR REPORTS A

7595
05:00:46,140 --> 05:00:50,078
YEAR AS OPPOSED TO FIVE.

7596
05:00:50,078 --> 05:00:50,378
>> KIM?

7597
05:00:50,378 --> 05:00:51,813
>> WELL, IT'S MORE THAN
THAT.

7598
05:00:51,813 --> 05:00:54,549
IT'S A LOT OF DIRECTOR REPORTS.

7599
05:00:54,549 --> 05:00:56,317
I GUESS -- IT'S TWO THINGS THAT

7600
05:00:56,317 --> 05:00:59,787
WE'RE TALKING ABOUT HERE.

7601
05:00:59,787 --> 05:01:05,493
NUMBER ONE, I AGREE FACE TO FACE

7602
05:01:05,493 --> 05:01:05,827
IS DIFFERENT.

7603
05:01:05,827 --> 05:01:07,328
AND SO DR. GRAY AND I HAVE

7604
05:01:07,328 --> 05:01:09,197
TALKED ABOUT THIS A LOT, HOW TO

7605
05:01:09,197 --> 05:01:10,498
TRY TO MAXIMIZE THE NUMBER OF

7606
05:01:10,498 --> 05:01:12,967
TIMES THAT WE'RE TOGETHER

7607
05:01:12,967 --> 05:01:14,669
WITHOUT HAVING TO, YOU KNOW,

7608
05:01:14,669 --> 05:01:15,670
IT'S ALSO A FISCAL

7609
05:01:15,670 --> 05:01:16,738
RESPONSIBILITY THING TO SAY, YOU

7610
05:01:16,738 --> 05:01:19,040
KNOW, IF WE HAVE TO CANCEL A

7611
05:01:19,040 --> 05:01:21,009
WHOLE MEETING WE LOSE A LOT OF

7612
05:01:21,009 --> 05:01:21,342
MONEY.

7613
05:01:21,342 --> 05:01:24,279
SO THAT'S WHERE WE'RE COMING UP

7614
05:01:24,279 --> 05:01:27,048
WITH HAVING FACE-TO-FACE DURING

7615
05:01:27,048 --> 05:01:29,651
GOOD WEATHER AND VIRTUAL, ALWAYS

7616
05:01:29,651 --> 05:01:30,852
VIRTUAL OPTION, DURING THE

7617
05:01:30,852 --> 05:01:33,154
TOUGHER WEATHER MONTHS.

7618
05:01:33,154 --> 05:01:34,489
WE'VE TALKED ABOUT SHIFTING THE

7619
05:01:34,489 --> 05:01:34,756
CALENDAR.

7620
05:01:34,756 --> 05:01:36,391
AS YOU KNOW WE'RE PLANNED OUT

7621
05:01:36,391 --> 05:01:38,960
TWO YEARS IN ADVANCE SO IT'S A

7622
05:01:38,960 --> 05:01:41,162
LITTLE BIT HARD BUT NOT

7623
05:01:41,162 --> 05:01:41,829
IMPOSSIBLE.

7624
05:01:41,829 --> 05:01:44,032
IT'S A DIFFERENT QUESTION ABOUT

7625
05:01:44,032 --> 05:01:44,432
SEPARATING.

7626
05:01:44,432 --> 05:01:45,533
WE SHOULD PROBABLY TAKE THAT

7627
05:01:45,533 --> 05:01:50,905
OFFLINE AND THINK ABOUT IT.

7628
05:01:50,905 --> 05:01:52,440
THAT'S IT'S FIRST IT'S BEEN

7629
05:01:52,440 --> 05:01:53,941
DISCUSSED, I DON'T KNOW THE

7630
05:01:53,941 --> 05:01:57,145
HISTORY IF THEY WERE APART AND

7631
05:01:57,145 --> 05:01:58,446
THEN BECAME TOGETHER.

7632
05:01:58,446 --> 05:01:59,647
BUT THERE ARE POTENTIALLY PROS

7633
05:01:59,647 --> 05:02:02,083
AND CONS TO BOTH.

7634
05:02:02,083 --> 05:02:05,820
>> I'VE BEEN SNOWED IN
HERE IN

7635
05:02:05,820 --> 05:02:07,789
APRIL FOR STUDY SECTION, HERE

7636
05:02:07,789 --> 05:02:09,624
FOR FIVE DAYS, UNPLEASANT

7637
05:02:09,624 --> 05:02:10,558
BECAUSE I ONLY PACKED FOR A DAY

7638
05:02:10,558 --> 05:02:14,896
AND A HALF. 

7639
05:02:14,896 --> 05:02:16,364
YEAH, GO AHEAD, KAREN.

7640
05:02:16,364 --> 05:02:18,199
>> I JUST WANT TO SAY THIS
HAS

7641
05:02:18,199 --> 05:02:21,803
BEEN -- I'VE BEEN ON THE NCAB

7642
05:02:21,803 --> 05:02:24,539
SINCE 2021, THIS IS MY FIRST

7643
05:02:24,539 --> 05:02:27,041
MEETING IN PERSON I'VE BEEN AT

7644
05:02:27,041 --> 05:02:28,910
JUST NCAB ALONE, A HUGE

7645
05:02:28,910 --> 05:02:29,210
DIFFERENCE.

7646
05:02:29,210 --> 05:02:31,412
A LOT OF RESEARCH IS PRESENTED,

7647
05:02:31,412 --> 05:02:31,646
RIGHT?

7648
05:02:31,646 --> 05:02:35,416
BACK TO BACK, WITH THE BSA, IT

7649
05:02:35,416 --> 05:02:36,884
BECOMES DIFFICULT, BUT FOR US TO

7650
05:02:36,884 --> 05:02:38,553
HAVE CONVERSATIONS WHAT DO WE

7651
05:02:38,553 --> 05:02:39,520
FUNDAMENTALLY NEED TO DO

7652
05:02:39,520 --> 05:02:41,689
DIFFERENTLY AT THE NCI, HOW DO

7653
05:02:41,689 --> 05:02:45,626
WE CHANGE PEOPLE'S  PERCEPTIONS

7654
05:02:45,626 --> 05:02:46,961
OF THE ORGANIZATION, THIS HAS

7655
05:02:46,961 --> 05:02:47,729
BEEN A WONDERFUL OPPORTUNITY,

7656
05:02:47,729 --> 05:02:48,830
I'LL SAY THAT.

7657
05:02:48,830 --> 05:02:50,565
I HEAR WHAT YOU'RE SAYING.

7658
05:02:50,565 --> 05:02:53,468
I'M FROM NEW YORK SO I KNOW

7659
05:02:53,468 --> 05:02:53,735
WEATHER.

7660
05:02:53,735 --> 05:02:55,169
EVEN THOUGH THINGS -- IT'S HARD

7661
05:02:55,169 --> 05:02:58,005
FOR STAFF, PEOPLE WHO LIVE HERE

7662
05:02:58,005 --> 05:03:00,074
TO GET THEIR, PROBABLY EASIER

7663
05:03:00,074 --> 05:03:04,779
FOR FOLKS TRAVELING IN,

7664
05:03:04,779 --> 05:03:06,214
DEPENDING WHAT CITY, BUT I'M

7665
05:03:06,214 --> 05:03:07,315
GLAD YOU'RE LOOKING AT SHIFTING.

7666
05:03:07,315 --> 05:03:08,883
THIS HAS BEEN A WONDERFUL

7667
05:03:08,883 --> 05:03:09,717
MEETING, AFTER THREE YEARS TO BE

7668
05:03:09,717 --> 05:03:11,686
IN THE ROOM AND HAVE THIS

7669
05:03:11,686 --> 05:03:13,554
CONVERSATION HAS BEEN GREAT.

7670
05:03:13,554 --> 05:03:15,423
>> LAST COMMENT, DR.
CLARK?

7671
05:03:15,423 --> 05:03:16,724
OH, KIM.

7672
05:03:16,724 --> 05:03:17,725
PUSH YOUR BUTTON.

7673
05:03:17,725 --> 05:03:19,127
>> MORE OF A QUESTION AND

7674
05:03:19,127 --> 05:03:19,994
CLARIFICATION FOR THE NEW PEOPLE

7675
05:03:19,994 --> 05:03:22,864
IN THE ROOM WHO MAY NOT EXACTLY

7676
05:03:22,864 --> 05:03:25,466
FOLLOW WHAT'S GOING ON.

7677
05:03:25,466 --> 05:03:26,934
SO, IS THE ASSUMPTION I'M

7678
05:03:26,934 --> 05:03:28,870
LOOKING AT THE FUTURE MEETINGS,

7679
05:03:28,870 --> 05:03:31,606
SO IN DECEMBER WHEN WE SAY JOINT

7680
05:03:31,606 --> 05:03:33,307
THAT WOULD BE --

7681
05:03:33,307 --> 05:03:34,809
>> NCAB, BSA.

7682
05:03:34,809 --> 05:03:35,476
>> IN PERSON?

7683
05:03:35,476 --> 05:03:35,877
>> UH-HUH.

7684
05:03:35,877 --> 05:03:36,310
>> OKAY.

7685
05:03:36,310 --> 05:03:39,614
AND IN FEBRUARY WE'RE LOOKING AT

7686
05:03:39,614 --> 05:03:41,048
JUST NCAB VIRTUAL?

7687
05:03:41,048 --> 05:03:43,751
AND THEN JUNE AGAIN JOINT IN

7688
05:03:43,751 --> 05:03:44,352
PERSON?

7689
05:03:44,352 --> 05:03:46,821
AND THEN SEPTEMBER NCAB IN

7690
05:03:46,821 --> 05:03:47,155
PERSON?

7691
05:03:47,155 --> 05:03:47,388
OKAY.

7692
05:03:47,388 --> 05:03:48,156
THANK YOU.

7693
05:03:48,156 --> 05:03:51,859
>> THAT'S WHERE WE ARE
NOW.

7694
05:03:51,859 --> 05:03:53,861
>> A COMMENT I WAS GOING
TO MAKE

7695
05:03:53,861 --> 05:03:56,564
IN TERMS OF HAVING FACE-TO-FACE

7696
05:03:56,564 --> 05:03:58,900
INTERACTION, THERE ARE OTHER

7697
05:03:58,900 --> 05:03:59,233
OPPORTUNITIES.

7698
05:03:59,233 --> 05:04:00,535
I THINK WORKSHOPS AND THINGS

7699
05:04:00,535 --> 05:04:02,103
LIKE THAT ALSO GIVE US

7700
05:04:02,103 --> 05:04:02,937
OPPORTUNITIES THROUGHOUT THE

7701
05:04:02,937 --> 05:04:04,772
YEAR TO GET TOGETHER.

7702
05:04:04,772 --> 05:04:08,709
IT'S NOT EXACTLY WHERE WE CAN DO

7703
05:04:08,709 --> 05:04:10,578
REAL POLICY WORK BUT IT'S WHERE

7704
05:04:10,578 --> 05:04:12,213
WE CAN DEVELOP SOME

7705
05:04:12,213 --> 05:04:13,080
RELATIONSHIPS.

7706
05:04:13,080 --> 05:04:14,949
>> YEAH, TWO MORE
COMMENTS,

7707
05:04:14,949 --> 05:04:16,384
SUCCINCT BECAUSE WE WANT TO MAKE

7708
05:04:16,384 --> 05:04:21,522
SURE WE HAVE TIME FOR THE CLOSED

7709
05:04:21,522 --> 05:04:22,190
SESSION.

7710
05:04:22,190 --> 05:04:24,025
FRED AND NELO.

7711
05:04:24,025 --> 05:04:30,398
>> IN TERMS OF JOINT
MEETINGS,

7712
05:04:30,398 --> 05:04:34,435
AT THE END OF THE DAY EACH BOARD

7713
05:04:34,435 --> 05:04:37,705
VOTING ON THE IMPORTANT ISSUES

7714
05:04:37,705 --> 05:04:40,408
THAT ARE DISCUSSED, SO IT SEEMS

7715
05:04:40,408 --> 05:04:43,778
LIKE TWO MEETINGS GOING ON IN

7716
05:04:43,778 --> 05:04:46,180
ONE LOCATION, AND, YOU KNOW, IN

7717
05:04:46,180 --> 05:04:48,516
TERMS OF PARTICIPATING IN THE

7718
05:04:48,516 --> 05:04:50,618
DISCUSSIONS FOR THE OTHER BOARD,

7719
05:04:50,618 --> 05:04:52,587
THAT MIGHT BE -- I'M NOT SURE

7720
05:04:52,587 --> 05:04:54,222
HOW IMPORTANT THAT IS, YOU KNOW,

7721
05:04:54,222 --> 05:05:00,328
WHETHER WHAT I SAY CAN INFLUENCE

7722
05:05:00,328 --> 05:05:02,196
BSA MEMBERS' VOTING DECISION,

7723
05:05:02,196 --> 05:05:05,066
THINGS LIKE THAT.

7724
05:05:05,066 --> 05:05:06,400
US SITTING AROUND THE TABLE AND

7725
05:05:06,400 --> 05:05:10,104
HAVING THE DISCUSSION TO ME IS

7726
05:05:10,104 --> 05:05:14,909
MORE PRODUCTIVE THAN THE JOINT

7727
05:05:14,909 --> 05:05:15,643
MEETINGS.

7728
05:05:15,643 --> 05:05:20,615
>> LAST COMMENT, NELO? 

7729
05:05:20,615 --> 05:05:24,218
>> I WANT TO ECHO WHAT
KAREN

7730
05:05:24,218 --> 05:05:26,521
SAID, WE JOINED AT THE SAME

7731
05:05:26,521 --> 05:05:26,754
TIME.

7732
05:05:26,754 --> 05:05:34,428
JUST IN TERMS OF PLANNING.

7733
05:05:34,428 --> 05:05:35,229
>> WONDERFUL.

7734
05:05:35,229 --> 05:05:37,265
SO, I THINK THIS IS GREAT

7735
05:05:37,265 --> 05:05:38,699
DISCUSSION.

7736
05:05:38,699 --> 05:05:39,333
AND WE'LL HAVE ADDITIONAL TIME

7737
05:05:39,333 --> 05:05:40,801
TO TALK ABOUT THESE THINGS,

7738
05:05:40,801 --> 05:05:43,404
MAYBE IN THE NEXT MEETING.

7739
05:05:43,404 --> 05:05:47,675
SO, THIS CONCLUDES THE OPEN

7740
05:05:47,675 --> 05:05:47,909
SESSION.

7741
05:05:47,909 --> 05:05:49,110
THERE'S NOW 13-MINUTE BREAK.

7742
05:05:49,110 --> 05:05:50,745
ONLY BOARD MEMBERS AND

7743
05:05:50,745 --> 05:05:51,746
DESIGNATED NCI STAFF SHOULD

7744
05:05:51,746 --> 05:05:52,280
RETURN.

7745
05:05:52,280 --> 05:05:54,148
MEMBERS WHO ARE ATTENDING

7746
05:05:54,148 --> 05:05:55,082
VIRTUALLY SHOULD SIGN OFF AND

7747
05:05:55,082 --> 05:05:57,885
SIGN BACK ON TO THE OTHER LINK

7748
05:05:57,885 --> 05:06:00,621
YOU RECEIVED, AROUND 3:27 OR SO.

7749
05:06:00,621 --> 05:06:03,124
USING YOUR NEW WEBEX LINKS.

7750
05:06:03,124 --> 05:06:13,234
THANK YOU