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I'D LIKE TO WELCOME THE MEMBERS

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OF THE NATIONAL CANCER ADVISORY

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BOARD, OFFICIAL MEMBERS,

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PRESIDENT'S CANCER PANEL

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MEMBERS, STAFF, AND GUESTS.

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MEMBERS OF THE PUBLIC WHO MAY 

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WISH TO EXPRESS THEIR VIEWS

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REGARDING ANY ITEMS DISCUSSED

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00:00:24,040 --> 00:00:26,520
DURING THIS MEETING MAY DO SO BY

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00:00:26,520 --> 00:00:30,640
WRITING DR. PAULETTE GRAY, THE 

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EXECUTIVE SECRETARY OF THE BOARD

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WITHIN TEN DAYS OF THE MEETING.

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ANY WRITTEN STATEMENTS OR

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QUESTIONS SUBMITTED BY MEMBERS

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OF THE PUBLIC WILL RECEIVE

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CAREFUL CONSIDERATION.

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BOARD MEMBERS, I WANT TO REMIND

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00:00:43,000 --> 00:00:47,040
YOU THAT YOU MUST ABSENT

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00:00:47,040 --> 00:00:48,240
YOURSELVES VIRTUALLY WHEN YOUR

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PARTICIPATION IN DELIBERATIONS

21
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ON A PARTICULAR PRODUCT,

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00:00:51,480 --> 00:00:53,240
PROGRAM, OR OTHER SPECIFIC

23
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MATTER WOULD CONSTITUTE CONFLICT

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OF INTEREST OR CREATE APPEARANCE

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00:00:56,160 --> 00:00:57,280
OF ONE.

26
00:00:57,280 --> 00:00:59,400
IT IS INCUMBENT UPON YOU TO

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ADVISE THE EXECUTIVE SECRETARY,

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00:01:01,320 --> 00:01:05,640
DR. GRAY, AND ABSTAIN FROM ANY

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PARTICIPATION, DISCUSSION, OR

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ACTIONS REGARDING THOSE MATTERS.

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IN LIGHT OF THE CURRENT POLICIES

32
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GOVERN CONFLICT OF INTEREST

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BASED ON FINANCIAL HOLDINGS OF 

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SPECIAL GOVERNMENT EMPLOYEES

35
00:01:17,400 --> 00:01:19,520
INCLUDING ALL MEMBERS OF THE

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BOARD WE MUST DEPEND ON YOU TO

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VOLUNTARY ABSENT YOURSELF ON

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MATTERS THAT COULD IMPACT THE

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00:01:26,240 --> 00:01:27,640
STATUS OF THOSE HOLDINGS.

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WE TRUST YOUR JUDGMENT IN THESE

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INSTANCES.

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DURING ANY CLOSED SESSION, ANY

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MATERIALS OR DISCUSSIONS OF

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CONFIDENTIAL NATURE, DELIBERATED

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ON TODAY, ARE PRIVILEGED

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INFORMATION.

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AND ARE MADE AVAILABLE TO YOU ON

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A NEED-TO-KNOW BASIS, SUCH

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DELIBERATIONS ARE PRIVATE AND

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CONTENT SHOULD NOT BE DIVULGED.

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SO, THE FUTURE MEETINGS, DATES

52
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OF FUTURE MEETINGS WERE PROVIDED

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TO ALL OF YOU AND ARE LISTED ON

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THE AGENDA.

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ALSO, WE NEED TO APPROVE THE

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JUNE 14-15, 2022 JOINT BSA NCAB 

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VIRTUAL MEETING SUMMARY.

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I'D LIKE TO CALL FOR A MOTION TO

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APPROVE THE MEETING SUMMARY.

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PLEASE UNMUTE IF YOU WOULD LIKE

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TO MAKE A MOTION.

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>> I MOVE.

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>> SECOND?

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>> SECOND.

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>> SECOND.

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>> PROPERLY MOVED AND
SECONDED.

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TO APPROVE THE MEETING MINUTES,

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LET'S VOTE.

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ARE THERE ANY NAYS?

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ANY ABSTENTION?

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PAULETTE, WE HAVE UNANIMOUS VOTE

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TO APPROVE.

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>> AGREED.

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>> BY LAW, A QUORUM OF
BOARD

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MEMBERS IS REQUIRED FOR EACH

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INSTANCE IN WHICH A VOTE MAY

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OCCUR, WHETHER IN OPEN OR CLOSED

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SESSION, DURING THIS MEETING A

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MINIMUM OF TEN APPOINTED MEMBERS

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MUST BE PRESENT TO VOICE THEIR

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VOTES.

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SINCE WE CAN'T PREDICT THE TIME

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OR OCCURRENCE OF ANY MOTION,

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YOUR PRESENCE IN THE VIRTUAL

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ROOM FOR ALL SEGMENTS OF THE

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00:03:06,640 --> 00:03:07,760
MEETINGS IS A MUST.

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PAULETTE, DO WE HAVE A QUORUM?

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>> YES.

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>> GREAT.

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SO, ALSO, FOR EVERYONE 

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PARTICIPATING IN THE MEETING,

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00:03:21,640 --> 00:03:24,040
PLEASE, IN ORDER TO MAKE SURE WE

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DON'T HAVE ANY INTERRUPTIONS

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00:03:25,160 --> 00:03:28,080
PLEASE MAKE SURE THAT YOU'RE

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00:03:28,080 --> 00:03:28,560
MUTED.

96
00:03:28,560 --> 00:03:31,600
AND REMAIN SO UNTIL RECOGNIZED

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BY EITHER MYSELF, PAULETTE,

98
00:03:33,120 --> 00:03:37,040
DOUG, OR WHOEVER THE SPEAKER IS.

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00:03:37,040 --> 00:03:39,240
SO, WE CAN NOW OPEN TODAY'S

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00:03:39,240 --> 00:03:41,880
MEETINGS BASED ON OUR CURRENT

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AGENDA, A REPORT FROM THE ACTING

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00:03:45,560 --> 00:03:50,800
NCI DIRECTOR, DR. DOUG LOWY.

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00:03:50,800 --> 00:03:51,280
DOUG?

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00:03:51,280 --> 00:03:52,280
>> JOHN, THANK YOU VERY
MUCH.

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00:03:52,280 --> 00:03:54,200
I WOULD LIKE TO WELCOME EVERYONE

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00:03:54,200 --> 00:03:56,720
FROM THE NATIONAL CANCER

107
00:03:56,720 --> 00:03:57,440
ADVISORY BOARD.

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00:03:57,440 --> 00:04:00,640
WE REALIZE THIS IS THE END OF

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AUGUST, IT IS BEFORE LABOR DAY,

110
00:04:04,360 --> 00:04:07,320
AND GREATLY APPRECIATE YOUR

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00:04:07,320 --> 00:04:09,040
ACTIVE PARTICIPATION TODAY.

112
00:04:09,040 --> 00:04:11,160
IN ADDITION, FOR THOSE PEOPLE

113
00:04:11,160 --> 00:04:13,400
WHO ARE NOT MEMBERS OF THE NCAB,

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00:04:13,400 --> 00:04:18,280
THANK YOU VERY MUCH FOR YOUR

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00:04:18,280 --> 00:04:19,880
INTEREST IN LISTENING ON THIS

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00:04:19,880 --> 00:04:20,480
IMPORTANT MEETING.

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IF I COULD HAVE THE FIRST SLIDE 

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PLEASE.

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I ENTITLED THIS PRESENTATION

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ENDING CANCER AS WE KNOW IT FOR

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ALL, WHICH REALLY TAKES AS ITS

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TITLE WHAT PRESIDENT BIDEN HAS

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SAID ON MORE THAN ONE OCCASION.

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AND I'M GOING TO -- IF I COULD

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HAVE THE SECOND SLIDE.

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I'M GOING TO TALK ABOUT A NUMBER

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OF DIFFERENT ISSUES, BUT 

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ULTIMATELY THEY REALLY ARE ABOUT

129
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TRYING TO IMPROVE THE OUTLOOK

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FOR PEOPLE WITH CANCER, AND TO

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THE EXTENT POSSIBLE FOR CANCER

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NOT TO HAPPEN AT ALL.

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I'M GOING TO GO OVER SOME NCI

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NEWS.

135
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THEN TALK ABOUT SCIENTIFIC

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UPDATES, CANCER MOONSHOT, AND

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FREDERICK NATIONAL LAB PROGRAMS.

138
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THESE WILL BE HIGH-LEVEL VIEWS

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FOR EACH OF THESE AREAS, AND I

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PLAN TO LEAVE ENOUGH TIME FOR

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NCAB MEMBERS TO FEEL COMFORTABLE

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IF THEY WANT TO ASK QUESTIONS

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AND/OR MAKE COMMENTS.

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LET'S GET TO SOME NCI NEWS,

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WHICH MANY OF YOU ARE AWARE THAT

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MONICA BERTINOLLI THIS MONTH WAS

147
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NAMED BY THE WHITE HOUSE TO

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BECOME THE NEW NCI DIRECTOR.

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SHE'S AN OUTSTANDING

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PHYSICIAN-SCIENTIST, SURGICAL

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ONCOLOGIST, FROM HARVARD, WE DO

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NOT KNOW EXACTLY WHEN SHE WILL

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BE APPOINTED.

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THE VETTING PROCESS TAKES A

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CERTAIN AMOUNT OF TIME BUT WE'RE

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LOOKING FORWARD TO HER ASSUMING

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THE LEADERSHIP ROLE OF THE NCI,

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AND AS MANY OF YOU ARE ALREADY

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AWARE SHE WILL BE THE FIRST

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WOMAN AS THE NCI DIRECTOR.

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NEXT SLIDE PLEASE.

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I WANTED TO HIGHLIGHT THAT WE

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ARE GOING TO -- WE PLAN TO

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PUBLISH IN A COUPLE OF WEEKS THE

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ANNUAL PLAN AND THE BUDGET

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PROPOSAL FOR FY 24, REFERRED TO 

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AS THE BYPASS BUDGET.

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WE ARE ALWAYS A YEAR AHEAD WITH

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PUBLISHING THE BUDGET.

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LAST YEAR WAS THE FY23 BUDGET,

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AND AS YOU WILL HEAR IN MORE

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DETAIL FROM M.K. HOLOHAN, FY 23

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IS A MERE FIVE WEEKS AWAY FROM

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TODAY, WHEN IT WILL START.

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FY 24 THEREFORE WON'T BE

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STARTING FOR 13 MONTHS.

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IN ADDITION TO THE BUDGET

178
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PROPOSAL, WE'RE GOING TO, AS

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WE'VE DONE IN THE PAST,

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HIGHLIGHT SEVERAL SCIENTIFIC

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OPPORTUNITIES.

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THIS IS NOT INTENDED TO BE

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COMPREHENSIVE.

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INSTEAD, IT IS SIMPLY TRYING TO

185
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TALK ABOUT AREAS WHERE WE SEE

186
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IMPORTANT NEEDS AS WELL AS

187
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OPPORTUNITIES.

188
00:08:03,280 --> 00:08:06,600
THEN THE FOUR AREAS THAT WILL BE

189
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HIGHLIGHTED THIS YEAR ARE

190
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MULTI-CANCER DETECTION TESTS,

191
00:08:11,760 --> 00:08:13,360
UNDRUGGABLE TARGETS, WHICH I

192
00:08:13,360 --> 00:08:16,440
THINK REALLY ARE BECOMING

193
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PROGRESSIVELY FEWER AND FEWER,

194
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CELL THERAPY, AND PERSISTENT

195
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POVERTY BECAUSE OF ITS EXTREME

196
00:08:26,840 --> 00:08:29,160
ASSOCIATION WITH CANCER

197
00:08:29,160 --> 00:08:30,240
DISPARITIES.

198
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NEXT SLIDE PLEASE.

199
00:08:31,600 --> 00:08:33,080
THIS IS THE ONE BUDGET SLIDE

200
00:08:33,080 --> 00:08:34,840
THAT I HAVE.

201
00:08:34,840 --> 00:08:36,840
M.K. HOLOHAN WILL GO INTO THINGS

202
00:08:36,840 --> 00:08:38,800
IN MORE DETAIL.

203
00:08:38,800 --> 00:08:41,640
I ACTUALLY SHOWED THIS SLIDE

204
00:08:41,640 --> 00:08:45,480
BACK IN JUNE, AND IT WAS TO TRY

205
00:08:45,480 --> 00:08:49,160
TO ESSENTIALLY SAY THAT WE THINK

206
00:08:49,160 --> 00:08:51,600
THAT THE BUDGET FOR F.Y. 23,

207
00:08:51,600 --> 00:08:55,000
ALTHOUGH IT HAS NOT YET BEEN

208
00:08:55,000 --> 00:08:57,960
ENACTED, IF IT FOLLOWS OTHER

209
00:08:57,960 --> 00:09:01,680
YEARS IT WILL BE SUBSTANTIALLY

210
00:09:01,680 --> 00:09:03,600
HIGHER THAN THE PRESIDENT'S

211
00:09:03,600 --> 00:09:07,400
BUDGET THAT WAS ANNOUNCED FOR

212
00:09:07,400 --> 00:09:09,840
FY23, AND, AGAIN, YOU'LL HEAR

213
00:09:09,840 --> 00:09:16,840
FROM M.K. HOLOHAN THAT THE HOUSE

214
00:09:16,840 --> 00:09:21,320
IS $466 MILLION HIGHER AND THE 

215
00:09:21,320 --> 00:09:22,520
PARTIAL SENATE MARK IS $290

216
00:09:22,520 --> 00:09:23,160
MILLION HIGHER.

217
00:09:23,160 --> 00:09:26,760
WE DO NOT KNOW WHERE IT WILL

218
00:09:26,760 --> 00:09:28,760
EVENTUALLY LAND OR WHEN THERE

219
00:09:28,760 --> 00:09:32,680
WILL BE A FULL YEAR BUDGET.

220
00:09:32,680 --> 00:09:33,440
NEXT SLIDE.

221
00:09:33,440 --> 00:09:40,600
SO, GETTING TO SOME OF THE

222
00:09:40,600 --> 00:09:43,560
SCIENCE, THIS PAPER THAT WAS

223
00:09:43,560 --> 00:09:45,560
PUBLISHED FROM THE INTRAMURAL

224
00:09:45,560 --> 00:09:48,440
PROGRAM, DIVISION OF CANCER

225
00:09:48,440 --> 00:09:52,840
EPIDEMIOLOGY AND GENETICS, LOOKS

226
00:09:52,840 --> 00:09:55,040
AT ALL CAUSE MORTALITY AND THE

227
00:09:55,040 --> 00:09:56,960
ASSOCIATION WITH PHYSICAL

228
00:09:56,960 --> 00:09:58,080
ACTIVITY.

229
00:09:58,080 --> 00:10:01,960
AND THERE ARE REALLY TWO

230
00:10:01,960 --> 00:10:03,600
IMPORTANT PARTS TO THIS AREA

231
00:10:03,600 --> 00:10:06,360
THAT I WANTED TO HIGHLIGHT.

232
00:10:06,360 --> 00:10:11,800
THE FIRST IS THAT IT IS AMONG

233
00:10:11,800 --> 00:10:14,320
OLDER ADULTS 59 TO 82, AVERAGE

234
00:10:14,320 --> 00:10:16,480
AGE WAS 70.

235
00:10:16,480 --> 00:10:22,040
THEY WERE FOLLOWED FOR MORE THAN

236
00:10:22,040 --> 00:10:23,000
TEN YEARS.

237
00:10:23,000 --> 00:10:25,320
THE SECOND POINT, THEY LOOKED AT

238
00:10:25,320 --> 00:10:26,800
DIFFERENT KINDS OF PHYSICAL

239
00:10:26,800 --> 00:10:30,000
ACTIVITY, AND NOT SHOWN IN THIS

240
00:10:30,000 --> 00:10:32,200
SLIDE BUT THE PAPER, THE

241
00:10:32,200 --> 00:10:35,680
CITATION FOR THE PAPER IS SHOWN

242
00:10:35,680 --> 00:10:39,400
ON THE BOTTOM, WATTS, ET AL.,

243
00:10:39,400 --> 00:10:43,760
REALLY SHOWED THAT THE MORTALITY

244
00:10:43,760 --> 00:10:44,760
RATES WERE RELATIVELY

245
00:10:44,760 --> 00:10:48,000
INDEPENDENT OF TYPE OF PHYSICAL

246
00:10:48,000 --> 00:10:51,600
ACTIVITY BUT INSTEAD REALLY

247
00:10:51,600 --> 00:10:56,880
DEPENDED ON THE AMOUNT OF

248
00:10:56,880 --> 00:10:58,800
PHYSICAL ACTIVITY, AS SHOWN IN

249
00:10:58,800 --> 00:11:00,080
THE GRAPH.

250
00:11:00,080 --> 00:11:03,920
WHAT THEY USE AS THE METRIC IS

251
00:11:03,920 --> 00:11:06,520
WHAT'S CALLED NET OR METABOLIC

252
00:11:06,520 --> 00:11:09,160
EQUIVALENT OF TASK.

253
00:11:09,160 --> 00:11:12,640
IT'S A MORE PRECISE MEASURE THAN

254
00:11:12,640 --> 00:11:15,240
JUST NUMBER OF MINUTES, BUT TO

255
00:11:15,240 --> 00:11:18,320
TRANSLATE THAT, IF YOU'RE

256
00:11:18,320 --> 00:11:21,680
WALKING AT 20 MINUTES PER MILE

257
00:11:21,680 --> 00:11:26,440
OR 3 MILES PER HOUR THAT'S 3

258
00:11:26,440 --> 00:11:26,880
METs.

259
00:11:26,880 --> 00:11:29,880
IF YOU DO FIVE HOURS OF WALKING,

260
00:11:29,880 --> 00:11:34,160
OF 3 MILES AN HOUR PER WEEK,

261
00:11:34,160 --> 00:11:37,680
THAT MEETS THE GOAL OF 15 MET.

262
00:11:37,680 --> 00:11:42,480
AND 7 1/2 IS HALF OF THAT.

263
00:11:42,480 --> 00:11:44,840
THERE'S A SUBSTANTIAL DECREASE

264
00:11:44,840 --> 00:11:48,760
IN MORTALITY RATE WHETHER IT'S

265
00:11:48,760 --> 00:11:55,520
CANCER MORTALITY, ALL-CAUSE 

266
00:11:55,520 --> 00:11:56,480
MORTALITY, OR CARDIOVASCULAR

267
00:11:56,480 --> 00:11:58,440
MORTALITY, BUT WHAT'S REALLY

268
00:11:58,440 --> 00:11:59,040
IMPORTANT THE COMPARATOR,

269
00:11:59,040 --> 00:12:03,400
BASICALLY THE PEOPLE THAT DIDN'T

270
00:12:03,400 --> 00:12:03,920
EXERCISE.

271
00:12:03,920 --> 00:12:05,920
SO, IT'S EXERCISING RATHER THAN

272
00:12:05,920 --> 00:12:08,320
THE TYPE OF EXERCISE THAT'S MOST

273
00:12:08,320 --> 00:12:09,920
IMPORTANT, AND IF PEOPLE DO MORE

274
00:12:09,920 --> 00:12:13,280
THAN ONE TYPE OF EXERCISE THAT'S

275
00:12:13,280 --> 00:12:13,760
GREAT.

276
00:12:13,760 --> 00:12:16,560
BUT FINDING SOMETHING THAT YOU

277
00:12:16,560 --> 00:12:23,600
FEEL COMFORTABLE DOING IS A WAY

278
00:12:23,600 --> 00:12:24,240
OF LIVING LONGER.

279
00:12:24,240 --> 00:12:24,560
NEXT SLIDE.

280
00:12:24,560 --> 00:12:29,200
THIS IS IN THE AREA OF CANCER

281
00:12:29,200 --> 00:12:36,320
TREATMENT WHERE THIS IS AN

282
00:12:36,320 --> 00:12:38,680
EXTENSION OF KEYNOTE 355 TRIAL

283
00:12:38,680 --> 00:12:43,600
PUBLISHED LAST MONTH, THIS IS AN

284
00:12:43,600 --> 00:12:47,480
INTERNATIONAL TRIAL WHICH 

285
00:12:47,480 --> 00:12:50,480
BASICALLY SHOWS A SURVIVAL

286
00:12:50,480 --> 00:12:54,240
BENEFIT AFTER APPROXIMATELY 3

287
00:12:54,240 --> 00:12:57,280
1/2 YEARS OF THE TRIAL FOR WOMEN

288
00:12:57,280 --> 00:12:58,800
WITH ADVANCED TRIPLE NEGATIVE

289
00:12:58,800 --> 00:13:04,280
BREAST CANCER WHO HAVE HIGHER

290
00:13:04,280 --> 00:13:09,000
LEVELS OF PD-1 USING A

291
00:13:09,000 --> 00:13:11,080
COMBINATION OF STANDARD

292
00:13:11,080 --> 00:13:13,360
CHEMOTHERAPY, PLUS

293
00:13:13,360 --> 00:13:17,520
PEMBROLIZUMAB.

294
00:13:17,520 --> 00:13:19,120
I THINK IT'S IMPORTANT THERE ARE

295
00:13:19,120 --> 00:13:21,480
SO MANY WOMEN WHO HAVE

296
00:13:21,480 --> 00:13:23,040
TRIPLE-NEGATIVE BREAST CANCER

297
00:13:23,040 --> 00:13:26,280
AND WE DON'T HAVE AS MUCH TO

298
00:13:26,280 --> 00:13:29,160
OFFER THEM AS WE HAVE FOR OTHER

299
00:13:29,160 --> 00:13:33,440
KINDS OF BREAST CANCER.

300
00:13:33,440 --> 00:13:36,800
NEXT SLIDE PLEASE.

301
00:13:36,800 --> 00:13:39,800
THIS SLIDE REALLY HIGHLIGHTS A

302
00:13:39,800 --> 00:13:41,640
TOBACCO CONTROL MONOGRAPH, WHICH

303
00:13:41,640 --> 00:13:44,680
IS FOCUSED ON THE AREA OF

304
00:13:44,680 --> 00:13:47,960
SMOKING CESSATION IN CANCER

305
00:13:47,960 --> 00:13:48,520
PATIENTS.

306
00:13:48,520 --> 00:13:52,280
AND THE EVIDENCE BECOMES

307
00:13:52,280 --> 00:13:54,320
PROGRESSIVELY STRONGER THAT IF

308
00:13:54,320 --> 00:13:57,800
PATIENTS ARE CURRENT SMOKERS AND

309
00:13:57,800 --> 00:14:01,200
THEY DEVELOP CANCER, THEIR

310
00:14:01,200 --> 00:14:04,200
OUTCOME, AS A GROUP, WILL BE

311
00:14:04,200 --> 00:14:07,520
BETTER IF THEY STOP SMOKING.

312
00:14:07,520 --> 00:14:10,120
AND THIS IS SOMETHING THAT

313
00:14:10,120 --> 00:14:16,880
CLEARLY AT THE CANCER CENTERS WE

314
00:14:16,880 --> 00:14:19,840
ARE STRIVING TO HAVE AS REALLY

315
00:14:19,840 --> 00:14:25,560
STANDARD OF CARE AT ALL OF THE

316
00:14:25,560 --> 00:14:26,200
NCI-DESIGNATED CANCER CENTERS.

317
00:14:26,200 --> 00:14:29,360
BUT WE WANT TO MAKE SURE THAT

318
00:14:29,360 --> 00:14:31,280
THIS PRACTICE GETS WIDELY

319
00:14:31,280 --> 00:14:33,360
DISSEMINATED FOR THE MANY

320
00:14:33,360 --> 00:14:36,280
PATIENTS WHO ARE TREATED OUTSIDE

321
00:14:36,280 --> 00:14:38,880
OF THE MAJOR CANCER CENTERS, AND

322
00:14:38,880 --> 00:14:42,240
I THINK THAT THE QUOTE HERE ON

323
00:14:42,240 --> 00:14:43,600
THE BOTTOM RECTANGLE, IT'S NEVER

324
00:14:43,600 --> 00:14:46,800
TOO LATE TO QUIT SMOKING, AND

325
00:14:46,800 --> 00:14:49,680
THERE ARE CLEAR BENEFITS FOR

326
00:14:49,680 --> 00:14:51,200
QUITTING SMOKING REGARDLESS OF

327
00:14:51,200 --> 00:14:53,800
CANCER TYPE.

328
00:14:53,800 --> 00:14:57,600
NEXT SLIDE.

329
00:14:57,600 --> 00:14:59,360
AND THIS SLIDE IS REALLY

330
00:14:59,360 --> 00:15:01,560
CONTINUING GOOD NEWS WHERE WE

331
00:15:01,560 --> 00:15:03,320
OFTEN LOOK AT WHAT'S HAPPENING

332
00:15:03,320 --> 00:15:05,880
WITH MORTALITY RATES WITH

333
00:15:05,880 --> 00:15:06,960
MORTALITY RATES GOING DOWN, BUT

334
00:15:06,960 --> 00:15:08,800
PART OF THE REASON THAT

335
00:15:08,800 --> 00:15:11,000
MORTALITY RATES ARE GOING DOWN

336
00:15:11,000 --> 00:15:14,000
IS THAT SURVIVAL RATES ARE GOING

337
00:15:14,000 --> 00:15:16,880
UP AND THE NUMBER OF SURVIVORS

338
00:15:16,880 --> 00:15:19,440
IN THE UNITED STATES REALLY

339
00:15:19,440 --> 00:15:22,160
CONTINUES TO INCREASE.

340
00:15:22,160 --> 00:15:24,880
WE NOW ARE SUBSTANTIALLY OVER 5%

341
00:15:24,880 --> 00:15:32,000
OF THE TOTAL POPULATION OF THE

342
00:15:32,000 --> 00:15:32,720
UNITED STATES ARE CANCER

343
00:15:32,720 --> 00:15:33,040
SURVIVORS.

344
00:15:33,040 --> 00:15:38,960
MORE THAN 2/3 OF THEM ARE OVER

345
00:15:38,960 --> 00:15:39,600
65.

346
00:15:39,600 --> 00:15:43,080
THIS IS SOMETHING REALLY TO BE

347
00:15:43,080 --> 00:15:44,680
CELEBRATED BUT WE WANT MORTALITY

348
00:15:44,680 --> 00:15:47,000
RATES TO GO DOWN FASTER AND FOR

349
00:15:47,000 --> 00:15:49,200
THERE TO BE EVEN MORE SURVIVORS.

350
00:15:49,200 --> 00:15:50,360
THANK YOU.

351
00:15:50,360 --> 00:15:55,400
NEXT SLIDE. 

352
00:15:55,400 --> 00:16:01,960
I NOW COME TO THE AREA OF THE

353
00:16:01,960 --> 00:16:02,600
CANCER MOONSHOT.

354
00:16:02,600 --> 00:16:07,040
AND I TALKED ABOUT IT A BIT IN

355
00:16:07,040 --> 00:16:07,240
JUNE.

356
00:16:07,240 --> 00:16:11,320
I NOW WANT TO UPDATE YOU WITH A

357
00:16:11,320 --> 00:16:13,320
SO-CALLED CANCER CABINET

358
00:16:13,320 --> 00:16:15,320
MEETING, THE FIRST LADY, DR.

359
00:16:15,320 --> 00:16:16,200
JILL BIDEN, PRESIDED AT THE

360
00:16:16,200 --> 00:16:18,400
WHITE HOUSE.

361
00:16:18,400 --> 00:16:24,280
THERE WERE MANY PEOPLE FROM

362
00:16:24,280 --> 00:16:25,320
DIFFERENT AGENCIES, MANY MEMBERS

363
00:16:25,320 --> 00:16:28,320
OF THE CABINET WHO PARTICIPATED.

364
00:16:28,320 --> 00:16:32,160
AND WHAT YOU CAN SEE ON THE

365
00:16:32,160 --> 00:16:36,160
RIGHT IS THAT THERE WERE A

366
00:16:36,160 --> 00:16:38,560
NUMBER OF PRIORITY ACTIONS AT

367
00:16:38,560 --> 00:16:41,040
THE CANCER CABINET, AND CLEARLY

368
00:16:41,040 --> 00:16:44,480
WE CAN EMBRACE ALL OF THEM.

369
00:16:44,480 --> 00:16:47,040
BUT I DO WANT TO HIGHLIGHT

370
00:16:47,040 --> 00:16:49,400
NUMBER 4, WHICH IS BRINGING

371
00:16:49,400 --> 00:16:51,520
CUTTING-EDGE RESEARCH THROUGH

372
00:16:51,520 --> 00:16:55,640
THE PIPELINE TO PATIENTS AND

373
00:16:55,640 --> 00:16:57,840
COMMUNITIES, BECAUSE AS I SAID

374
00:16:57,840 --> 00:17:01,800
AT THAT MEETING, EVEN IF WE CUT

375
00:17:01,800 --> 00:17:04,440
MORTALITY RATES BY 50% OR MORE,

376
00:17:04,440 --> 00:17:07,680
IF WE AREN'T GOING TO CHANGE THE

377
00:17:07,680 --> 00:17:11,560
OUTLOOK FOR PEOPLE WHO HAVE

378
00:17:11,560 --> 00:17:12,320
CANCERS WHERE CURRENTLY THERE'S

379
00:17:12,320 --> 00:17:14,920
NOT THAT MUCH THAT WE CAN DO TO

380
00:17:14,920 --> 00:17:17,480
HELP THEM, WE WILL NOT BE ENDING

381
00:17:17,480 --> 00:17:21,280
CANCER AS WE KNOW IT.

382
00:17:21,280 --> 00:17:23,800
ON THE LEFT SIDE YOU CAN SEE THE

383
00:17:23,800 --> 00:17:27,520
FACT SHEET WHERE IT SAYS

384
00:17:27,520 --> 00:17:30,280
PRESIDENT BIDEN APPOINTS CANCER

385
00:17:30,280 --> 00:17:30,960
PANEL MEMBERS.

386
00:17:30,960 --> 00:17:37,440
AND THAT'S SHOWN ON THE NEXT 

387
00:17:37,440 --> 00:17:38,360
SLIDE.

388
00:17:38,360 --> 00:17:39,480
THIS ONCE AGAIN, ELIZABETH

389
00:17:39,480 --> 00:17:43,720
JAFFE, CAROL BROWN AND MITCHELL

390
00:17:43,720 --> 00:17:51,320
BERGER HAVE BEEN NAMED VERY 

391
00:17:51,320 --> 00:17:52,440
ANALOGOUS TO MONICA BERTAGNOLLI

392
00:17:52,440 --> 00:17:54,360
BUT NOT YET APPOINTED.

393
00:17:54,360 --> 00:17:55,600
I WANT TO ACKNOWLEDGE, I'M SURE

394
00:17:55,600 --> 00:18:01,160
THEY WILL DO A GREAT JOB BUT I

395
00:18:01,160 --> 00:18:03,440
WANT TO ACKNOWLEDGE THE

396
00:18:03,440 --> 00:18:04,560
INCREDIBLE JOB - NEXT SLIDE

397
00:18:04,560 --> 00:18:06,680
PLEASE - THAT THE CURRENT

398
00:18:06,680 --> 00:18:08,080
MEMBERS OF THE PRESIDENT'S

399
00:18:08,080 --> 00:18:11,720
CANCER PANEL HAVE DONE, JOHN

400
00:18:11,720 --> 00:18:13,280
WILLIAMS, EDITH MITCHELL, AND

401
00:18:13,280 --> 00:18:15,000
ROBERT INGRAHAM.

402
00:18:15,000 --> 00:18:18,040
AS YOU MAY REMEMBER FROM THE

403
00:18:18,040 --> 00:18:23,040
PRESENTATION THAT JOHN WILLIAMS 

404
00:18:23,040 --> 00:18:33,440
MADE BACK IN JUNE, THEIR

405
00:18:34,760 --> 00:18:36,360
MONOGRAPH WAS BRIDGING THE

406
00:18:36,360 --> 00:18:38,040
CANCER SCREENING GAP, EXACTLY

407
00:18:38,040 --> 00:18:39,440
NUMBER ONE PRIORITY ANNOUNCED AT

408
00:18:39,440 --> 00:18:42,280
THE CANCER CABINET.

409
00:18:42,280 --> 00:18:45,800
NEXT SLIDE.

410
00:18:45,800 --> 00:18:48,080
 

411
00:18:48,080 --> 00:18:52,360
THE MOONSHOT, THE NEXT PHASE,

412
00:18:52,360 --> 00:18:58,920
YOU'VE ALREADY HEARD PREVIEWS OF

413
00:18:58,920 --> 00:19:00,720
THIS WHEREAS WE DO WITH ALL OF

414
00:19:00,720 --> 00:19:04,760
OUR RFAs, THE BOARD OF

415
00:19:04,760 --> 00:19:06,000
SCIENTIFIC ADVISORS REVIEW THEM

416
00:19:06,000 --> 00:19:08,360
BUT YOU WERE PRESENT AT THE

417
00:19:08,360 --> 00:19:10,600
JOINT BOARD MEETING WHERE WE

418
00:19:10,600 --> 00:19:14,200
DISCUSSED THE MOONSHOT SCHOLARS

419
00:19:14,200 --> 00:19:16,600
PROGRAM, AND PREVIOUSLY

420
00:19:16,600 --> 00:19:18,120
TELEHEALTH AND MULTI-CANCER

421
00:19:18,120 --> 00:19:18,480
DETECTION.

422
00:19:18,480 --> 00:19:21,320
AND THOSE THREE PROGRAMS ARE

423
00:19:21,320 --> 00:19:23,280
GETTING OFF THE GROUND WHERE WE

424
00:19:23,280 --> 00:19:25,240
ANTICIPATE THE FIRST SET OF

425
00:19:25,240 --> 00:19:29,120
MOONSHOT SCHOLARS WILL BE NEXT

426
00:19:29,120 --> 00:19:30,160
YEAR.

427
00:19:30,160 --> 00:19:34,000
TELEHEALTH MADE THE FIRST AWARDS

428
00:19:34,000 --> 00:19:36,880
ACTUALLY A FEW WEEKS AGO.

429
00:19:36,880 --> 00:19:40,880
AND MULTI-CANCER DETECTION, AS

430
00:19:40,880 --> 00:19:43,520
YOU HEARD IN JUNE, IT WAS

431
00:19:43,520 --> 00:19:45,080
ROUNDLY ENDORSED AND GOING

432
00:19:45,080 --> 00:19:47,560
FORWARD TO TRY TO DEVELOP THAT

433
00:19:47,560 --> 00:19:52,600
IMPORTANT AREA.

434
00:19:52,600 --> 00:19:53,840
NEXT SLIDE.

435
00:19:53,840 --> 00:19:57,920
SO, THE NEXT THREE SLIDES REALLY

436
00:19:57,920 --> 00:20:03,080
ARE TALKING ABOUT TRYING TO

437
00:20:03,080 --> 00:20:04,320
OVERCOME HEALTH DISPARITIES, AND

438
00:20:04,320 --> 00:20:08,320
ONE OF THE AREAS THAT NCI HAS

439
00:20:08,320 --> 00:20:11,560
HAD A LONG-TERM COMMITMENT IS

440
00:20:11,560 --> 00:20:17,720
WITH CLINICAL TRIAL ENROLLMENT 

441
00:20:17,720 --> 00:20:23,080
FOR NCI CLINICAL TRIALS.

442
00:20:23,080 --> 00:20:25,080
DR. MCCASKILL-STEVENS AND HER

443
00:20:25,080 --> 00:20:27,360
COLLEAGUES HAVE DONE AN AMAZING

444
00:20:27,360 --> 00:20:30,120
JOB AS YOU SEE SUMMARIZED ON THE

445
00:20:30,120 --> 00:20:30,480
RIGHT.

446
00:20:30,480 --> 00:20:32,680
WHEN WE STARTED THIS EFFORT NOW

447
00:20:32,680 --> 00:20:35,560
20 YEARS AGO, ABOUT 14% OF THE

448
00:20:35,560 --> 00:20:37,080
ENROLLMENT WAS MINORITIES.

449
00:20:37,080 --> 00:20:42,280
BUT IN THE MOST RECENT FULL

450
00:20:42,280 --> 00:20:44,200
THREE-YEAR PERIOD BEFORE THE

451
00:20:44,200 --> 00:20:47,480
PANDEMIC BEGAN, IT HAD INCREASED

452
00:20:47,480 --> 00:20:48,520
TO 25%.

453
00:20:48,520 --> 00:20:52,880
AND MOST OF THE INCREASE IS IN

454
00:20:52,880 --> 00:20:55,480
AFRICAN AMERICAN AND HISPANIC

455
00:20:55,480 --> 00:20:57,160
POPULATIONS.

456
00:20:57,160 --> 00:20:58,440
ACTUALLY, ESPECIALLY HISPANIC

457
00:20:58,440 --> 00:20:59,840
POPULATIONS.

458
00:20:59,840 --> 00:21:02,720
AND THE DATA DURING THE PANDEMIC

459
00:21:02,720 --> 00:21:06,200
HAVE NOT GONE DOWN IN TERMS OF

460
00:21:06,200 --> 00:21:08,280
MINORITY ENROLLMENT, BUT WE

461
00:21:08,280 --> 00:21:11,000
DON'T HAVE REALLY OFFICIAL DATA

462
00:21:11,000 --> 00:21:15,160
YET FOR 20 AND 21.

463
00:21:15,160 --> 00:21:15,600
NEXT SLIDE.

464
00:21:15,600 --> 00:21:19,360
SO, ONE OF THE THINGS THAT I

465
00:21:19,360 --> 00:21:23,400
TALKED ABOUT IN JUNE WAS THAT A

466
00:21:23,400 --> 00:21:25,040
VERY IMPORTANT PART OF WHAT WE

467
00:21:25,040 --> 00:21:27,000
SEE AS THE NEW PHASE OF THE

468
00:21:27,000 --> 00:21:31,000
CANCER MOONSHOT IS TO INCREASE

469
00:21:31,000 --> 00:21:32,800
ENROLLMENT OF UNDERREPRESENTED

470
00:21:32,800 --> 00:21:35,880
GROUPS, TO NCI CLINICAL TRIALS.

471
00:21:35,880 --> 00:21:41,480
AND PART OF THE GOAL IS TO MIMIC

472
00:21:41,480 --> 00:21:43,080
THE AT-RISK POPULATION FOR THIS

473
00:21:43,080 --> 00:21:43,960
SPECIFIC CANCER STUDY.

474
00:21:43,960 --> 00:21:47,600
SO WE KNOW THAT THE RESULTS WILL

475
00:21:47,600 --> 00:21:50,640
BE MORE REPRESENTATIVE.

476
00:21:50,640 --> 00:21:54,680
SO, THIS IS TO HAVE MORE

477
00:21:54,680 --> 00:21:56,440
UNDERREPRESENTED MINORITIES IN

478
00:21:56,440 --> 00:21:59,280
TRIALS, BUT ALSO PATIENTS WITH

479
00:21:59,280 --> 00:22:00,000
COMORBIDITIES, PATIENTS FROM

480
00:22:00,000 --> 00:22:00,800
RURAL AREAS.

481
00:22:00,800 --> 00:22:04,520
IN ORDER TO DO THIS, WE ARE

482
00:22:04,520 --> 00:22:05,720
GOING TO NEED GREATER INVESTMENT

483
00:22:05,720 --> 00:22:09,320
BECAUSE IT'S GOING TO BE

484
00:22:09,320 --> 00:22:12,120
CRITICAL TO HAVE COMMUNITY

485
00:22:12,120 --> 00:22:12,520
ENGAGEMENT.

486
00:22:12,520 --> 00:22:16,160
AND WE NEED TO MODIFY THINGS IF

487
00:22:16,160 --> 00:22:18,280
WE'RE GOING TO INCREASE

488
00:22:18,280 --> 00:22:20,800
ENROLLMENT, NOT JUST AT THE

489
00:22:20,800 --> 00:22:22,920
LEVEL OF THE PATIENT BUT ALSO AT

490
00:22:22,920 --> 00:22:25,040
THE LEVEL OF THE HEALTH CARE

491
00:22:25,040 --> 00:22:25,960
PROVIDER.

492
00:22:25,960 --> 00:22:30,160
SO THAT THERE IS MORE DIVERSITY

493
00:22:30,160 --> 00:22:31,280
AMONG HEALTH CARE PROVIDERS.

494
00:22:31,280 --> 00:22:35,040
AND WE ARE IN THE PROCESS OF

495
00:22:35,040 --> 00:22:37,880
TAKING STEPS TO TRY TO ENSURE

496
00:22:37,880 --> 00:22:41,080
THAT THIS IS GOING TO BECOME

497
00:22:41,080 --> 00:22:44,400
MORE OF A REALITY.

498
00:22:44,400 --> 00:22:46,720
NEXT SLIDE.

499
00:22:46,720 --> 00:22:48,960
THIS IS JUST AN ANNOUNCEMENT OR,

500
00:22:48,960 --> 00:22:52,560
IF YOU WILL, LETTING EVERYONE

501
00:22:52,560 --> 00:22:54,160
KNOW THAT IN NOVEMBER THERE'S

502
00:22:54,160 --> 00:22:58,360
GOING TO BE AN NCI SUMMIT ON

503
00:22:58,360 --> 00:23:00,440
INCREASING DIVERSITY, EQUITY,

504
00:23:00,440 --> 00:23:01,440
INCLUSION IN EARLY-PHASE

505
00:23:01,440 --> 00:23:01,960
CLINICAL TRIALS.

506
00:23:01,960 --> 00:23:05,640
ABILITY THE GOAL WILL BE TO

507
00:23:05,640 --> 00:23:07,040
IDENTIFY AND DISCUSS

508
00:23:07,040 --> 00:23:09,040
IMPLEMENTATION, BEST PRACTICES

509
00:23:09,040 --> 00:23:12,000
FOR INCREASING INCLUSION AND

510
00:23:12,000 --> 00:23:14,760
EQUITY IN OUR CANCER CLINICAL

511
00:23:14,760 --> 00:23:15,120
TRIALS.

512
00:23:15,120 --> 00:23:18,320
AND THE NCI EQUITY INCLUSION

513
00:23:18,320 --> 00:23:21,960
PROGRAM WILL BE HOSTING THIS AND

514
00:23:21,960 --> 00:23:23,680
REGISTRATION INFORMATION WILL BE

515
00:23:23,680 --> 00:23:27,560
AVAILABLE IN THE NEAR FUTURE.

516
00:23:27,560 --> 00:23:28,920
NEXT SLIDE.

517
00:23:28,920 --> 00:23:32,640
I'M NOW GOING TO TURN TO THE

518
00:23:32,640 --> 00:23:35,400
LAST THREE SLIDES, WHICH IS

519
00:23:35,400 --> 00:23:36,880
TALKING ABOUT FREDERICK.

520
00:23:36,880 --> 00:23:41,360
WE'RE GOING TO HAVE A LARGER

521
00:23:41,360 --> 00:23:41,920
DISCUSSION OF THE FREDERICK

522
00:23:41,920 --> 00:23:44,360
NATIONAL LABORATORY WHEN WE HAVE

523
00:23:44,360 --> 00:23:46,360
THE JOINT BOARD MEETING IN

524
00:23:46,360 --> 00:23:46,960
DECEMBER.

525
00:23:46,960 --> 00:23:50,440
BUT I WANTED TO TELL YOU ABOUT

526
00:23:50,440 --> 00:23:53,120
THREE THINGS.

527
00:23:53,120 --> 00:23:55,200
THE FIRST IS THAT MONKEYPOX HAS

528
00:23:55,200 --> 00:24:03,560
OF COURSE BEEN IN THE NEWS VERY 

529
00:24:03,560 --> 00:24:05,160
HIGH PROFILE.

530
00:24:05,160 --> 00:24:07,280
AND THERE ACTUALLY IS TREATMENT

531
00:24:07,280 --> 00:24:11,840
AVAILABLE BUT HASN'T BEEN

532
00:24:11,840 --> 00:24:12,840
SUBJECTED TO RIGOROUS EFFICACY

533
00:24:12,840 --> 00:24:16,880
TRIAL IN PEOPLE.

534
00:24:16,880 --> 00:24:18,680
SO THE FREDERICK NATIONAL

535
00:24:18,680 --> 00:24:29,240
LABORATORY AND  AUSPICE OF NIAID

536
00:24:29,560 --> 00:24:32,000
HAS BEEN WORKING WITH THE

537
00:24:32,000 --> 00:24:37,080
REPUBLIC OF THE CONGO CAN THE

538
00:24:37,080 --> 00:24:40,440
OUTBREAK OF STRAIN 1, CAUSING

539
00:24:40,440 --> 00:24:42,360
MORE THAN THE STRAIN 3 IN THE

540
00:24:42,360 --> 00:24:43,680
UNITED STATES, THE EFFICACY

541
00:24:43,680 --> 00:24:48,640
TRIAL HOPEFULLY WILL LEAD TO

542
00:24:48,640 --> 00:24:53,080
DEMONSTRATION OF EFFICACY AND

543
00:24:53,080 --> 00:24:56,160
ANTICIPATION IF STRAIN 1 WILL IS

544
00:24:56,160 --> 00:24:57,920
DEMONSTRATED EFFICACY WILL ALSO

545
00:24:57,920 --> 00:25:06,280
WILL BE FOR STRAIN 3.

546
00:25:06,280 --> 00:25:06,920
NEXT SLIDE.

547
00:25:06,920 --> 00:25:13,080
IN ADDITION, THE IMPORTANCE OF

548
00:25:13,080 --> 00:25:14,840
TRAINING AND DIVERSITY AND

549
00:25:14,840 --> 00:25:18,640
EQUITY DOESN'T JUST STAY IN

550
00:25:18,640 --> 00:25:22,400
BETHESDA BUT ALSO EXTENDS TO THE

551
00:25:22,400 --> 00:25:23,480
FREDERICK NATIONAL LABORATORY.

552
00:25:23,480 --> 00:25:26,920
AND THERE ARE A NUMBER OF

553
00:25:26,920 --> 00:25:30,040
ACADEMIC PARTNERSHIPS THAT HAVE

554
00:25:30,040 --> 00:25:37,760
BEEN DEVELOPED IN RECENT YEARS

555
00:25:37,760 --> 00:25:39,120
WITH ETHAN DEMOTROSKI LEADING

556
00:25:39,120 --> 00:25:40,280
THE EFFORT WITH SEMINARS,

557
00:25:40,280 --> 00:25:41,520
GRADUATE STUDENTS FROM

558
00:25:41,520 --> 00:25:43,800
UNDERREPRESENTED GROUPS, AND

559
00:25:43,800 --> 00:25:46,200
MORE PARTNERSHIPS UNDERWAY.

560
00:25:46,200 --> 00:25:52,000
MY LAST SLIDE, WHICH IS THE NEXT

561
00:25:52,000 --> 00:25:55,680
SLIDE, TALKS ABOUT A SURPRISING

562
00:25:55,680 --> 00:26:00,840
VISIT THAT WE HAD A FEW WEEKS

563
00:26:00,840 --> 00:26:04,920
AGO TO FREDERICK, WHERE WE HAD

564
00:26:04,920 --> 00:26:08,040
SECRETARY BECERRA AND THE TWO

565
00:26:08,040 --> 00:26:10,760
SENATORS FROM MARYLAND, BEN

566
00:26:10,760 --> 00:26:13,320
CARDON AND CHRIS VALHOLEN AND

567
00:26:13,320 --> 00:26:17,400
ONE OF THE CONGRESSMEN FROM

568
00:26:17,400 --> 00:26:20,200
MARYLAND, DAVID TRONE, COME TO

569
00:26:20,200 --> 00:26:27,920
THE FREDERICK NATIONAL

570
00:26:27,920 --> 00:26:29,160
LABORATORY TO SEE IT, THEY HAVE

571
00:26:29,160 --> 00:26:31,520
ALL BEEN WITH THE EXCEPTION OF

572
00:26:31,520 --> 00:26:37,080
SECRETARY BECERRA, AND WE TALKED

573
00:26:37,080 --> 00:26:37,720
ABOUT THE CAPABILITIES

574
00:26:37,720 --> 00:26:40,040
ESPECIALLY IN AREAS OF CANCER

575
00:26:40,040 --> 00:26:43,040
RESEARCH FOR THE FREDERICK

576
00:26:43,040 --> 00:26:49,560
NATIONAL LABORATORY, AND MELINDA

577
00:26:49,560 --> 00:26:55,800
HOLLINGSHEAD FROM NCI RUNS THE

578
00:26:55,800 --> 00:26:58,320
MOUSE MODELS REPOSITORY,

579
00:26:58,320 --> 00:26:59,440
PATIENT-DERIVED MODELS

580
00:26:59,440 --> 00:27:00,440
REPOSITORY, GAVE THEM

581
00:27:00,440 --> 00:27:03,080
DEMONSTRATION OF PATIENT DERIVED

582
00:27:03,080 --> 00:27:05,520
XENOGRAFTS DEVELOPED FROM

583
00:27:05,520 --> 00:27:10,600
PATIENT TUMORS AND EVERYONE WAS

584
00:27:10,600 --> 00:27:12,520
VERY ENGAGED AND DR.

585
00:27:12,520 --> 00:27:14,920
HOLLINGSHEAD DID A TERRIFIC JOB

586
00:27:14,920 --> 00:27:22,360
IN EXPLAINING HOW WE DEVELOP

587
00:27:22,360 --> 00:27:22,560
THESE.

588
00:27:22,560 --> 00:27:24,360
WE NOW HAVE 600 MODELS WITH THE

589
00:27:24,360 --> 00:27:26,200
GOAL OF GETTING TO 1,000, MADE

590
00:27:26,200 --> 00:27:31,040
READILY AVAILABLE TO THE CANCER

591
00:27:31,040 --> 00:27:32,000
RESEARCH COMMUNITY FOR PEOPLE

592
00:27:32,000 --> 00:27:37,080
WHO WANT TO DO VARIOUS KINDS OF

593
00:27:37,080 --> 00:27:38,920
TRANSLATIONAL RESEARCH

594
00:27:38,920 --> 00:27:46,920
ESPECIALLY FOR DEVELOPING NEW

595
00:27:46,920 --> 00:27:47,440
INTERVENTIONS.

596
00:27:47,440 --> 00:27:48,400
THAT WAS AN UNEXPECTED

597
00:27:48,400 --> 00:27:51,760
OPPORTUNITY TO TALK ABOUT THE

598
00:27:51,760 --> 00:27:52,720
FREDERICK NATIONAL LABORATORY,

599
00:27:52,720 --> 00:27:57,400
NATIONAL CANCER INSTITUTE, DR.

600
00:27:57,400 --> 00:28:00,720
TABAK CAME UP FROM BETHESDA.

601
00:28:00,720 --> 00:28:04,600
IT REALLY WAS AN IMPORTANT

602
00:28:04,600 --> 00:28:07,320
OPPORTUNITY TO TELL THEM ABOUT

603
00:28:07,320 --> 00:28:09,480
THE OPPORTUNITIES THAT WE SEE

604
00:28:09,480 --> 00:28:12,640
FOR CANCER RESEARCH.

605
00:28:12,640 --> 00:28:14,840
SO, I'LL STOP NOW AND THANK YOU

606
00:28:14,840 --> 00:28:16,360
FOR YOUR ATTENTION.

607
00:28:16,360 --> 00:28:18,560
AND LOOK FORWARD TO YOUR

608
00:28:18,560 --> 00:28:23,240
QUESTIONS AND YOUR COMMENTS.

609
00:28:23,240 --> 00:28:23,960
 

610
00:28:23,960 --> 00:28:24,880
>> THANK YOU, DOUG.

611
00:28:24,880 --> 00:28:27,840
WE NOW OPEN THE FLOOR FOR

612
00:28:27,840 --> 00:28:28,120
QUESTIONS.

613
00:28:28,120 --> 00:28:31,680
WE HAVE TIME FOR QUITE A FEW

614
00:28:31,680 --> 00:28:31,960
QUESTIONS.

615
00:28:31,960 --> 00:28:34,200
I WOULD, YOU KNOW, FROM A

616
00:28:34,200 --> 00:28:35,520
STANDPOINT OF JUST CHAIR'S

617
00:28:35,520 --> 00:28:37,600
PREROGATIVE WANT TO THANK YOU

618
00:28:37,600 --> 00:28:38,840
FOR DISCUSSING THE PDX NET AND

619
00:28:38,840 --> 00:28:40,720
ALL THE WORK IN DEVELOPING THE

620
00:28:40,720 --> 00:28:41,000
MODELS.

621
00:28:41,000 --> 00:28:43,680
I THINK, YOU KNOW, ONE REALLY

622
00:28:43,680 --> 00:28:46,040
IMPORTANT POINT IS SOME OF THE

623
00:28:46,040 --> 00:28:50,880
PROGRAMS THAT ARE IN PLAY TO

624
00:28:50,880 --> 00:28:54,320
INCREASE DIVERSITY.

625
00:28:54,320 --> 00:29:01,320
THE EXPANSION OF PBX NET TO 

626
00:29:01,320 --> 00:29:02,080
DERIVE 60% FROM MINORITY

627
00:29:02,080 --> 00:29:05,800
PATIENTS TO UNDERSTAND THE

628
00:29:05,800 --> 00:29:08,440
BROADER CONTEXT OF CANCER WITH A

629
00:29:08,440 --> 00:29:09,440
MORE DIVERSE SET OF MODELS.

630
00:29:09,440 --> 00:29:11,000
>> THANK YOU FOR POINTING
THAT

631
00:29:11,000 --> 00:29:15,360
OUT, JOHN, CLEARLY AN IMPORTANT

632
00:29:15,360 --> 00:29:16,000
AND NEEDED INITIATIVE.

633
00:29:16,000 --> 00:29:18,360
>> SO I KNOW WE'RE GOING
TO HAVE

634
00:29:18,360 --> 00:29:22,720
AN EXPANDED DISCUSSION ON NCI

635
00:29:22,720 --> 00:29:25,040
FREDERICK AT THE JOINT BSA

636
00:29:25,040 --> 00:29:27,080
MEETING YOU MENTIONED.

637
00:29:27,080 --> 00:29:28,720
BUT IF YOU COULD, IS IT POSSIBLE

638
00:29:28,720 --> 00:29:32,760
TO AT LEAST PROVIDE SOME CONTEXT

639
00:29:32,760 --> 00:29:34,640
AROUND HOW THAT OPERATION WORKS

640
00:29:34,640 --> 00:29:37,840
IN TERMS OF ITS FUNDING, ITS

641
00:29:37,840 --> 00:29:40,040
RELATIONSHIP WITH NCI, AND I

642
00:29:40,040 --> 00:29:42,480
KNOW THE RECOMPETING AND THINGS

643
00:29:42,480 --> 00:29:45,600
OF THAT NATURE.

644
00:29:45,600 --> 00:29:49,560
>> SO, THE FREDERICK
NATIONAL

645
00:29:49,560 --> 00:29:53,880
LABORATORY IS REALLY, IF YOU

646
00:29:53,880 --> 00:29:56,960
WILL, A GOVERNMENT RESOURCE.

647
00:29:56,960 --> 00:30:03,520
IT IS A CONTRACT LABORATORY.

648
00:30:03,520 --> 00:30:05,520
AND ABOUT I WOULD SAY -- THE

649
00:30:05,520 --> 00:30:09,160
AMOUNT OF MONEY THAT IS SPENT UP

650
00:30:09,160 --> 00:30:12,880
THERE VARIES WITH THE YEARS, BUT

651
00:30:12,880 --> 00:30:16,240
ABOUT TWO-THIRDS OF THE FUNDING

652
00:30:16,240 --> 00:30:20,240
COMES FROM NCI, AND ONE-THIRD

653
00:30:20,240 --> 00:30:23,080
FROM NIAID, WITH A NUMBER OF

654
00:30:23,080 --> 00:30:29,240
DIFFERENT AGENCIES AND OTHER 

655
00:30:29,240 --> 00:30:35,640
PARTS OF NIH BENEFITING FROM IT.

656
00:30:35,640 --> 00:30:39,800
IN TERMS OF THE ACTIVITIES, ONE

657
00:30:39,800 --> 00:30:44,000
OF THE AREAS THAT WE ESSENTIALLY

658
00:30:44,000 --> 00:30:45,560
TRANSITIONED TO WAS LOOKING AT

659
00:30:45,560 --> 00:30:51,480
COVID IN A NUMBER OF DIFFERENT 

660
00:30:51,480 --> 00:30:55,080
WAYS DURING THE PANDEMIC, NCI

661
00:30:55,080 --> 00:31:00,120
TOOK A LEAD ROLE IN SEROLOGY.

662
00:31:00,120 --> 00:31:03,440
AND WE ACTUALLY ENDED UP

663
00:31:03,440 --> 00:31:06,680
ESSENTIALLY BEING A TEST CENTER

664
00:31:06,680 --> 00:31:12,080
FOR THE FDA, AND THEY USED OUR

665
00:31:12,080 --> 00:31:14,360
RESULTS AS AN IMPORTANT

666
00:31:14,360 --> 00:31:18,800
PARAMETER IN DECIDING WHETHER

667
00:31:18,800 --> 00:31:20,000
EMERGENCY USE AUTHORIZATIONS

668
00:31:20,000 --> 00:31:21,120
WERE GIVEN TO DIFFERENT

669
00:31:21,120 --> 00:31:23,640
COMPANIES THAT WERE MAKING

670
00:31:23,640 --> 00:31:24,680
VARIOUS DEVICES.

671
00:31:24,680 --> 00:31:30,600
MOST OF WHAT WE DO IS CANCER

672
00:31:30,600 --> 00:31:32,320
RESEARCH.

673
00:31:32,320 --> 00:31:37,920
YOU HAVE HEARD ABOUT THE RAS

674
00:31:37,920 --> 00:31:41,680
INITIATIVE, AND DINAH SINGER AND

675
00:31:41,680 --> 00:31:45,760
OTHERS ARE INVOLVED IN LOOKING

676
00:31:45,760 --> 00:31:47,560
AT BASICALLY HEARING FROM THE

677
00:31:47,560 --> 00:31:49,080
COMMUNITY, FIRST WITH AN RFI,

678
00:31:49,080 --> 00:31:52,800
AND THEN GOING OUT ACTUALLY IN

679
00:31:52,800 --> 00:31:56,840
THE COMMUNITY AND ASKING PEOPLE

680
00:31:56,840 --> 00:31:59,400
WHAT ARE SOME SIGNATURE

681
00:31:59,400 --> 00:32:09,840
INITIATIVES THAT MIGHT BE 

682
00:32:15,040 --> 00:32:16,880
PURSUED AT FREDERICK.

683
00:32:16,880 --> 00:32:20,920
FREDERICK AS A RESOURCE FOR

684
00:32:20,920 --> 00:32:23,080
MODELS, PATIENT DERIVED

685
00:32:23,080 --> 00:32:28,040
REPOSITORY, SPHEROID AND OTHER 

686
00:32:28,040 --> 00:32:31,200
MODELS, THE RAS INITIATIVE HAS

687
00:32:31,200 --> 00:32:36,280
PATHWAY REAGENTS OF VARIOUS

688
00:32:36,280 --> 00:32:37,920
TYPES. 

689
00:32:37,920 --> 00:32:39,120
THE FREDERICK NATIONAL

690
00:32:39,120 --> 00:32:44,160
LABORATORY, WHEN WE STOOD UP THE

691
00:32:44,160 --> 00:32:47,560
MATCH TRIAL, IT WAS IMPORTANT TO

692
00:32:47,560 --> 00:32:51,480
HAVE MULTIPLE CENTERS FOR

693
00:32:51,480 --> 00:32:58,280
SEQUENCING FOR DETERMINING IF 

694
00:32:58,280 --> 00:32:59,680
PATIENTS WOULD BE ELIGIBLE TO

695
00:32:59,680 --> 00:33:01,320
JOIN THE MATCH TRIAL.

696
00:33:01,320 --> 00:33:03,400
THAT WAS CENTERED AT FREDERICK.

697
00:33:03,400 --> 00:33:06,000
AND THE OTHER CENTERS, THERE WAS

698
00:33:06,000 --> 00:33:07,840
A LOT OF UPFRONT WORK THAT WENT

699
00:33:07,840 --> 00:33:13,360
TO MAKE SURE THAT THERE WAS AT 

700
00:33:13,360 --> 00:33:15,680
LEAST 95% AGREEMENT BETWEEN THE

701
00:33:15,680 --> 00:33:17,720
DIFFERENT GROUPS.

702
00:33:17,720 --> 00:33:20,320
THE NEXT PROGRAM FOR EXAMPLE,

703
00:33:20,320 --> 00:33:24,160
YOU KNOW, WHICH WE HAVE

704
00:33:24,160 --> 00:33:30,360
PRESENTED IN THE RECENT PAST,

705
00:33:30,360 --> 00:33:32,440
WHICH REALLY IS INVESTIGATOR --

706
00:33:32,440 --> 00:33:36,600
IF YOU WILL, IT'S

707
00:33:36,600 --> 00:33:37,040
INVESTIGATOR-INITIATED

708
00:33:37,040 --> 00:33:38,240
TRANSLATION WHERE GROUPS THEN

709
00:33:38,240 --> 00:33:43,960
APPLY TO TRY TO DEVELOP THEIR

710
00:33:43,960 --> 00:33:45,120
TRANSLATIONAL IDEAS.

711
00:33:45,120 --> 00:33:49,080
I THINK I'VE GONE ON ENOUGH.

712
00:33:49,080 --> 00:33:50,320
>> THIS IS GREAT.

713
00:33:50,320 --> 00:33:52,720
ARE THERE ANY OTHER QUESTIONS?

714
00:33:52,720 --> 00:33:56,920
PLEASE USE THE RAISE YOUR HAND

715
00:33:56,920 --> 00:33:57,440
TOOL.

716
00:33:57,440 --> 00:33:58,520
>> YEAH, QUICKLY, DOUG, I
KNOW A

717
00:33:58,520 --> 00:34:00,200
LOT OF PEOPLE ARE ASKING

718
00:34:00,200 --> 00:34:03,000
THEMSELF THE FOLLOWING QUESTION.

719
00:34:03,000 --> 00:34:08,360
YOU KNOW, HOW THE PAYLINES LOOK

720
00:34:08,360 --> 00:34:09,600
FOR 2023, WE KNOW 2022 IS PRETTY

721
00:34:09,600 --> 00:34:10,440
MUCH IN THE BAG.

722
00:34:10,440 --> 00:34:11,840
>> YEAH, AS SOON AS YOU
TELL ME

723
00:34:11,840 --> 00:34:15,800
WHAT OUR BUDGET IS FOR FY23, I

724
00:34:15,800 --> 00:34:17,080
WILL GIVE YOU AN ANSWER.

725
00:34:17,080 --> 00:34:18,160
>> I WAS JUST GIVING YOU A

726
00:34:18,160 --> 00:34:19,440
CHANCE TO ANSWER THAT QUESTION

727
00:34:19,440 --> 00:34:21,400
SO EVERYONE KNOWS WE DON'T HAVE

728
00:34:21,400 --> 00:34:25,040
A BUDGET FOR 2023.

729
00:34:25,040 --> 00:34:31,160
IF I COULD FOLLOW UP --

730
00:34:31,160 --> 00:34:32,360
>> INSTEAD, LET ME --

731
00:34:32,360 --> 00:34:33,680
>> THAT'S OKAY, JUST
GIVING YOU

732
00:34:33,680 --> 00:34:36,120
A CHANCE TO SAY THAT.

733
00:34:36,120 --> 00:34:39,960
>> THIS IS A VERY, VERY
HIGH

734
00:34:39,960 --> 00:34:40,600
PRIORITY.

735
00:34:40,600 --> 00:34:46,760
AS I HAVE TALKED WITH YOU

736
00:34:46,760 --> 00:34:49,600
PREVIOUSLY, WE ARE PROGRESSIVELY

737
00:34:49,600 --> 00:34:52,520
INCREASING THE INVESTMENT IN THE

738
00:34:52,520 --> 00:34:54,840
RPG POOL, COMPARED TO ITS

739
00:34:54,840 --> 00:34:57,280
PERCENTAGE OF THE OVERALL NCI

740
00:34:57,280 --> 00:34:59,320
BUDGET, WHICH HAS LED TO AN

741
00:34:59,320 --> 00:35:01,520
OVERALL INCREASE IN THE

742
00:35:01,520 --> 00:35:04,040
PERCENTAGE OF THE NCI BUDGET

743
00:35:04,040 --> 00:35:06,880
THAT IS IN THE RPG POOL.

744
00:35:06,880 --> 00:35:10,800
AND WE LOOK FORWARD TO DOING

745
00:35:10,800 --> 00:35:11,040
THAT.

746
00:35:11,040 --> 00:35:12,160
>> YEAH A FOLLOW-UP, I WAS

747
00:35:12,160 --> 00:35:13,240
ASKING BECAUSE I REALLY WANTED

748
00:35:13,240 --> 00:35:15,280
TO ASK THIS QUESTION.

749
00:35:15,280 --> 00:35:18,160
DO YOU SEE ANY REAL LEVELING OFF

750
00:35:18,160 --> 00:35:20,560
OR EVEN ANY DECREASE IN THE

751
00:35:20,560 --> 00:35:26,800
NUMBER OF GRANT APPLICATIONS,

752
00:35:26,800 --> 00:35:27,720
ESPECIALLY R01s?

753
00:35:27,720 --> 00:35:28,960
>> THE SHORT ANSWER, THE
BIG

754
00:35:28,960 --> 00:35:31,320
INCREASE THAT WE SAW A NUMBER OF

755
00:35:31,320 --> 00:35:35,320
YEARS AGO SEEMS TO HAVE

756
00:35:35,320 --> 00:35:35,880
PLATEAUED, YES.

757
00:35:35,880 --> 00:35:37,360
>> THAT'S ONE OF THE
REASONS

758
00:35:37,360 --> 00:35:38,600
OBVIOUSLY FOR OUR SUCCESS RATE,

759
00:35:38,600 --> 00:35:41,880
AND I THINK THAT'S NOT ALWAYS

760
00:35:41,880 --> 00:35:43,520
UNDERSTOOD.

761
00:35:43,520 --> 00:35:44,040
THANK YOU.

762
00:35:44,040 --> 00:35:46,000
>> YEAH, AND, YOU KNOW, I
THINK

763
00:35:46,000 --> 00:35:48,080
THAT IF YOU LOOK AT THE METRIC

764
00:35:48,080 --> 00:35:50,000
OF HOW MANY AWARDS ARE WE

765
00:35:50,000 --> 00:35:54,640
GIVING, YOU KNOW, WE'RE GIVING

766
00:35:54,640 --> 00:35:57,120
MORE AWARDS EVERY YEAR.

767
00:35:57,120 --> 00:35:58,880
BUT THE -- YOU KNOW, WE HAVEN'T

768
00:35:58,880 --> 00:36:04,560
BEEN ABLE TO KEEP PACE WITH THE

769
00:36:04,560 --> 00:36:05,480
NUMBER OF APPLICATIONS, EVEN

770
00:36:05,480 --> 00:36:09,080
WITH THEM BEING FLAT.

771
00:36:09,080 --> 00:36:12,000
BUT, YOU KNOW, NED REALLY

772
00:36:12,000 --> 00:36:15,280
DEVELOPED THE IDEA OF 15 BY 25.

773
00:36:15,280 --> 00:36:21,200
WE NEEDED TO TAKE A PAUSE DURING

774
00:36:21,200 --> 00:36:24,480
FY 22 BUT I'LL -- YOU KNOW, TELL

775
00:36:24,480 --> 00:36:27,080
YOU THAT WE WENT FROM WE WENT

776
00:36:27,080 --> 00:36:29,480
FROM 8 TO 11, YOU KNOW, IN A

777
00:36:29,480 --> 00:36:31,480
VERY SHORT TIME PERIOD.

778
00:36:31,480 --> 00:36:34,320
AND I'M HOPEFUL THAT WE WILL BE

779
00:36:34,320 --> 00:36:38,600
ABLE TO RESUME GOING UP TOWARDS

780
00:36:38,600 --> 00:36:40,520
15 BY 25.

781
00:36:40,520 --> 00:36:46,080
BUT AS YOU UNDERSTAND, IT REALLY

782
00:36:46,080 --> 00:36:48,400
IS DEPENDENT ON CONGRESS.

783
00:36:48,400 --> 00:36:52,480
>> SO, DOUG, JUST TO
AGUESS

784
00:36:52,480 --> 00:36:55,400
DOVETAIL OFF THE CONVERSATION, I

785
00:36:55,400 --> 00:36:56,640
THINK ONE OF THE ISSUES THAT'S

786
00:36:56,640 --> 00:36:58,360
NEAR AND DEAR TO THE HEARTS OF

787
00:36:58,360 --> 00:37:00,840
MANY OF OUR MEMBERS AND THE

788
00:37:00,840 --> 00:37:03,560
COMMUNITY AS A WHOLE ARE ESIs.

789
00:37:03,560 --> 00:37:06,520
AND SO, CAN YOU SPEAK TO, YOU

790
00:37:06,520 --> 00:37:08,680
KNOW, WHERE WE ARE WITH THAT?

791
00:37:08,680 --> 00:37:13,280
>> JOHN, WE CONTINUE TO
GIVE

792
00:37:13,280 --> 00:37:14,840
ESIs A 5 PERCENTILE BOOST,

793
00:37:14,840 --> 00:37:15,760
OKAY?

794
00:37:15,760 --> 00:37:18,800
WHENEVER WE TALK ABOUT THE

795
00:37:18,800 --> 00:37:23,080
PAYLINE, IF IT'S 11 FOR

796
00:37:23,080 --> 00:37:25,200
EXPERIENCED INVESTIGATORS, IT'S

797
00:37:25,200 --> 00:37:26,320
16 FOR ESIs.

798
00:37:26,320 --> 00:37:29,400
WE HAVE GIVEN MANY MORE AWARDS,

799
00:37:29,400 --> 00:37:30,920
I DON'T WANT TO MAKE A MISTAKE

800
00:37:30,920 --> 00:37:33,760
AND GIVE YOU THE QUANTITATION,

801
00:37:33,760 --> 00:37:36,120
BUT WE'VE GIVEN MANY MORE AWARDS

802
00:37:36,120 --> 00:37:37,560
TO ESI, LET'S SAY LAST YEAR,

803
00:37:37,560 --> 00:37:43,640
THAN WE DID THREE OR FOUR YEARS

804
00:37:43,640 --> 00:37:43,800
AGO.

805
00:37:43,800 --> 00:37:45,360
ELECTRA, YOU HAVE A QUESTION?

806
00:37:45,360 --> 00:37:46,240
>> HI, DOUG.

807
00:37:46,240 --> 00:37:47,640
THANK YOU SO MUCH FOR YOUR

808
00:37:47,640 --> 00:37:50,360
REPORT, ALL THAT YOU DO AND WILL

809
00:37:50,360 --> 00:37:53,000
CONTINUE TO DO, I KNOW YOU WILL.

810
00:37:53,000 --> 00:37:56,600
I JUST WANTED TO MAKE A POINT

811
00:37:56,600 --> 00:38:00,880
AND ESPECIALLY FOR THE RECORD, I

812
00:38:00,880 --> 00:38:04,240
APPRECIATE THE MOONSHOT

813
00:38:04,240 --> 00:38:07,880
CONSIDERATION OF ENROLLING

814
00:38:07,880 --> 00:38:08,640
UNDERREPRESENTED POPULATIONS,

815
00:38:08,640 --> 00:38:09,520
THROUGH TRIALS, THAT WOULD

816
00:38:09,520 --> 00:38:13,680
REPRESENT THE POPULATION WITH

817
00:38:13,680 --> 00:38:14,480
THAT DISEASE.

818
00:38:14,480 --> 00:38:17,000
I THINK THAT'S FABULOUS.

819
00:38:17,000 --> 00:38:18,720
IT'S A HUMONGOUS START, A GREAT

820
00:38:18,720 --> 00:38:20,480
CHANGE FROM WHERE WE ARE.

821
00:38:20,480 --> 00:38:25,480
BUT I WOULD REALLY LIKE TO

822
00:38:25,480 --> 00:38:27,360
REMIND PEOPLE THAT IF WE WANT TO

823
00:38:27,360 --> 00:38:30,560
SAY THAT A  TREATMENT, FOR

824
00:38:30,560 --> 00:38:36,080
EXAMPLE, WILL WORK IN LET'S SAY 

825
00:38:36,080 --> 00:38:37,000
A SPECIFIC MINORITY POPULATION,

826
00:38:37,000 --> 00:38:39,240
WHERE THE QUESTION IS RELEVANT

827
00:38:39,240 --> 00:38:40,800
AND IMPORTANT FOR THAT MINORITY

828
00:38:40,800 --> 00:38:45,160
POPULATION WE'RE GOING TO HAVE

829
00:38:45,160 --> 00:38:46,920
TO RECRUIT PATIENTS TO THE

830
00:38:46,920 --> 00:38:49,080
NUMBER THAT WE WILL HAVE

831
00:38:49,080 --> 00:38:50,520
SUFFICIENT STATISTICAL POWER TO

832
00:38:50,520 --> 00:38:55,520
ANSWER THAT QUESTION FOR THAT 

833
00:38:55,520 --> 00:38:55,880
RESEARCH GROUP.

834
00:38:55,880 --> 00:38:58,800
SO, WE IN THE ALLIANCE FOR

835
00:38:58,800 --> 00:38:59,960
CLINICAL TRIALS HAVE BEEN

836
00:38:59,960 --> 00:39:02,400
LOOKING AT THIS.

837
00:39:02,400 --> 00:39:05,600
AND WE ACTUALLY HAVE SEVERAL

838
00:39:05,600 --> 00:39:08,920
TRIALS THROUGH THE NCTN 

839
00:39:08,920 --> 00:39:12,040
MECHANISM THAT ARE TAILORED TO

840
00:39:12,040 --> 00:39:12,680
CERTAIN UNDERREPRESENTED

841
00:39:12,680 --> 00:39:14,840
POPULATION GROUPS, AND ONE IS

842
00:39:14,840 --> 00:39:15,960
OUR GET SET STUDY, FOR EXAMPLE,

843
00:39:15,960 --> 00:39:20,840
WE SET A GOAL TO ENROLL 30%

844
00:39:20,840 --> 00:39:25,800
MINORITY WOMEN, AND WE HAVE

845
00:39:25,800 --> 00:39:27,200
CLOSED CELLS TO YOUNG WHITE

846
00:39:27,200 --> 00:39:28,120
WOMEN BECAUSE WE HAVE FILLED

847
00:39:28,120 --> 00:39:29,880
THOSE CELLS UP.

848
00:39:29,880 --> 00:39:34,040
AND WE'RE NOW ONLY RECRUITING

849
00:39:34,040 --> 00:39:36,480
BLACK WOMEN, YOUNG WOMEN, TO

850
00:39:36,480 --> 00:39:36,880
THAT.

851
00:39:36,880 --> 00:39:43,160
AND ONE MORE POINT I WANT TO

852
00:39:43,160 --> 00:39:50,280
MAKE SO PEOPLE KNOW WE CAN DO

853
00:39:50,280 --> 00:39:50,920
THIS, MONICA BERTAGNOLLI WAS THE

854
00:39:50,920 --> 00:39:54,480
GROUP CHAIR AND GAVE US A

855
00:39:54,480 --> 00:39:54,960
CHALLENGE 30% MINORITY

856
00:39:54,960 --> 00:39:55,640
REPRESENTATION ON THE CLINICAL

857
00:39:55,640 --> 00:39:56,080
TRIALS.

858
00:39:56,080 --> 00:40:00,240
AS OF LAST MONTH IN ALLIANCE, WE

859
00:40:00,240 --> 00:40:04,800
WERE ALMOST 24% FOR TREATMENT

860
00:40:04,800 --> 00:40:06,480
TRIALS, AND ALMOST 44% FOR

861
00:40:06,480 --> 00:40:08,880
CANCER CONTROL TRIALS.

862
00:40:08,880 --> 00:40:11,480
SO, WE DID IT BY THE TOP SAYS

863
00:40:11,480 --> 00:40:13,400
YOU'RE GOING TO DO IT.

864
00:40:13,400 --> 00:40:17,200
SECOND OF ALL, YOU KNOW, WE 

865
00:40:17,200 --> 00:40:19,040
OPENED PROTOCOLS THAT

866
00:40:19,040 --> 00:40:19,560
SPECIFICALLY ADDRESS OUR

867
00:40:19,560 --> 00:40:20,640
MINORITY POPULATIONS AND THE

868
00:40:20,640 --> 00:40:23,440
ISSUES THAT WERE RELEVANT TO

869
00:40:23,440 --> 00:40:26,720
THEM, AND WHERE APPROPRIATE WE

870
00:40:26,720 --> 00:40:28,680
MADE SURE IN PROTOCOLS THAT WE

871
00:40:28,680 --> 00:40:30,520
SET OUR ACCRUAL TARGETS NOT JUST

872
00:40:30,520 --> 00:40:33,640
TO BE REPRESENTATIVE OF THE

873
00:40:33,640 --> 00:40:35,400
POPULATION WITH THE DISEASE BUT

874
00:40:35,400 --> 00:40:40,880
FHIR SO WE COULD SAY IN THAT

875
00:40:40,880 --> 00:40:42,120
POPULATION IF THE TREATMENT, IF

876
00:40:42,120 --> 00:40:43,160
THE INTERVENTION ALSO WORKED.

877
00:40:43,160 --> 00:40:47,520
AND I WOULD REALLY LIKE FOR THE

878
00:40:47,520 --> 00:40:49,720
SCIENTIFIC COMMUNITY TO REALLY

879
00:40:49,720 --> 00:40:52,040
VIEW THIS DIFFERENTLY AND REALLY

880
00:40:52,040 --> 00:40:54,640
ASPIRE TO THESE GOALS BECAUSE

881
00:40:54,640 --> 00:40:57,600
PERSONALLY I DON'T THINK WHERE

882
00:40:57,600 --> 00:40:59,600
APPROPRIATE IT'S ADEQUATE ENOUGH

883
00:40:59,600 --> 00:41:00,680
JUST TO RECRUIT TO THE

884
00:41:00,680 --> 00:41:02,640
DISTRIBUTION OF THE DISEASE IN

885
00:41:02,640 --> 00:41:03,680
THE POPULATION.

886
00:41:03,680 --> 00:41:05,640
THANKS, DOUG, FOR LETTING ME SAY

887
00:41:05,640 --> 00:41:08,000
THAT.

888
00:41:08,000 --> 00:41:09,080
>> THANK YOU, ELECTRA.

889
00:41:09,080 --> 00:41:12,480
ANNA, YOUR HAND IS UP. 

890
00:41:12,480 --> 00:41:14,320
IS THAT FROM PREVIOUS OR --

891
00:41:14,320 --> 00:41:16,160
>> I'M SORRY, I'LL TAKE
THAT

892
00:41:16,160 --> 00:41:19,080
DOWN, YES.

893
00:41:19,080 --> 00:41:22,240
>> ANYWAY, WE'RE GETTING
CLOSE 

894
00:41:22,240 --> 00:41:25,520
TO THE 2:00 -- JOHN, FOR YOU,

895
00:41:25,520 --> 00:41:26,120
11:00.

896
00:41:26,120 --> 00:41:27,360
>> WE HAVE A COUPLE
MINUTES IF

897
00:41:27,360 --> 00:41:31,160
THERE ARE ANY OTHER BURNING

898
00:41:31,160 --> 00:41:31,560
QUESTIONS.

899
00:41:31,560 --> 00:41:33,560
>> YES.

900
00:41:33,560 --> 00:41:37,760
 

901
00:41:37,760 --> 00:41:41,360
>> YOU NEED TO UNMUTE,
HOWARD.

902
00:41:41,360 --> 00:41:45,320
>> DOUG, COULD YOU GIVE US
A

903
00:41:45,320 --> 00:41:46,920
COMMENT ON YOUR PREDICTED

904
00:41:46,920 --> 00:41:49,360
DIRECTIONS AND HOW WE'RE SEEING

905
00:41:49,360 --> 00:41:54,960
FRUIT COMING FROM THE OTHER --

906
00:41:54,960 --> 00:41:57,040
FROM THE SIMX AND

907
00:41:57,040 --> 00:41:58,320
IMMUNO-ONCOLOGY BIOMARKERS NOW

908
00:41:58,320 --> 00:41:59,640
GETTING PUBLISHED AND VALIDATION

909
00:41:59,640 --> 00:42:01,760
WORK GOING ON, DO YOU SEE HOW

910
00:42:01,760 --> 00:42:03,800
THAT MIGHT BE COMING BACK TO

911
00:42:03,800 --> 00:42:06,680
FURTHER ADVANCE THE GOALS THAT

912
00:42:06,680 --> 00:42:07,760
ELECTRA ARTICULATED, NOT ONLY

913
00:42:07,760 --> 00:42:16,360
JUST ACCRUAL BUT LET'S SAY GOOD

914
00:42:16,360 --> 00:42:17,560
RESPONSES, NOT WASTING TIME OF

915
00:42:17,560 --> 00:42:19,280
THE PATIENTS WHO DO ENROLL IN

916
00:42:19,280 --> 00:42:20,200
THOSE STUDIES.

917
00:42:20,200 --> 00:42:23,040
>> THEY HAVE REALLY BEEN

918
00:42:23,040 --> 00:42:24,400
VALIDATING ASSAYS AND SHOWING

919
00:42:24,400 --> 00:42:27,920
THAT THEY ARE RIGOROUS.

920
00:42:27,920 --> 00:42:30,440
JIM DOROSHOW IS HERE, AND JIM

921
00:42:30,440 --> 00:42:34,200
MIGHT WANT TO COMMENT FURTHER.

922
00:42:34,200 --> 00:42:34,760
JIM?

923
00:42:34,760 --> 00:42:36,160
>> THANKS, DOUG.

924
00:42:36,160 --> 00:42:37,200
THANKS FOR THE QUESTION.

925
00:42:37,200 --> 00:42:41,680
SO, I THINK THE THING THAT IS

926
00:42:41,680 --> 00:42:45,400
PROBABLY MOST IMPORTANT IN THE

927
00:42:45,400 --> 00:42:49,120
INTERMEDIATE TERM IS THAT

928
00:42:49,120 --> 00:42:51,440
BECAUSE SIMAC ASSAY, IT'S A

929
00:42:51,440 --> 00:42:53,520
GREAT PROGRAM, BUT IT'S BASED ON

930
00:42:53,520 --> 00:42:55,400
OBTAINING SAMPLES FROM PATIENTS

931
00:42:55,400 --> 00:42:57,120
ALREADY ACCRUED TO TRIALS.

932
00:42:57,120 --> 00:43:03,440
WE ARE VERY FAR ALONG, AND IN A

933
00:43:03,440 --> 00:43:04,840
SUBSEQUENT MEET WILL GO SHARE

934
00:43:04,840 --> 00:43:06,760
THE NEW ACTIVITIES WE'RE

935
00:43:06,760 --> 00:43:09,040
UNDERTAKING BUT ONE IS I-MATCH,

936
00:43:09,040 --> 00:43:11,880
FOR THE FIRST TIME PATIENTS WILL

937
00:43:11,880 --> 00:43:15,800
GET A STANDARDIZED SET OF

938
00:43:15,800 --> 00:43:16,880
IMMUNOLOGICAL MARKERS BEFORE

939
00:43:16,880 --> 00:43:18,240
THEY GO ON TRIAL, HIGHLY

940
00:43:18,240 --> 00:43:26,880
VALIDATED,  DONE IN CORE 

941
00:43:26,880 --> 00:43:27,880
LABORATORIES, TO DEVELOPING

942
00:43:27,880 --> 00:43:28,160
BIOMARKERS.

943
00:43:28,160 --> 00:43:29,360
IT'S DIVERSITY RESULT TO PREDICT

944
00:43:29,360 --> 00:43:30,800
WHO WILL RESPOND AND WHO WILL

945
00:43:30,800 --> 00:43:31,320
NOT.

946
00:43:31,320 --> 00:43:32,560
THE ASSAYS ARE NOT STANDARDIZED

947
00:43:32,560 --> 00:43:33,800
SO WE HOPE TO BE ABLE TO SET UP

948
00:43:33,800 --> 00:43:35,600
A WAY IN WHICH WE CAN ACCRUE A

949
00:43:35,600 --> 00:43:37,160
SUBSTANTIAL NUMBER OF PATIENTS

950
00:43:37,160 --> 00:43:39,320
AND THEN GET FEEDBACK TO

951
00:43:39,320 --> 00:43:40,080
UNDERSTAND BETTER AND BETTER

952
00:43:40,080 --> 00:43:42,280
WAYS TO USE THAT INFORMATION TO

953
00:43:42,280 --> 00:43:43,480
CHOOSE PATIENTS FOR IMMUNE

954
00:43:43,480 --> 00:43:46,080
MODULATED TRIALS.

955
00:43:46,080 --> 00:43:49,920
 

956
00:43:49,920 --> 00:43:51,360
>> THANKS, JIM.

957
00:43:51,360 --> 00:43:53,640
WE'RE AT TOP OF HOUR.

958
00:43:53,640 --> 00:43:56,320
DOUG, THANKS FOR THE DIRECTOR'S

959
00:43:56,320 --> 00:43:56,640
REPORT.

960
00:43:56,640 --> 00:43:59,280
NEXT AGENDA ITEM IS REPORT FROM

961
00:43:59,280 --> 00:44:01,400
M.K. HOLOHAN WHICH WILL BE THE

962
00:44:01,400 --> 00:44:03,600
LEGISLATIVE REPORT.

963
00:44:03,600 --> 00:44:04,400
M.K.?

964
00:44:04,400 --> 00:44:05,280
>> THANK YOU, DR. CARPTEN.

965
00:44:05,280 --> 00:44:06,680
THANK YOU FOR THE OPPORTUNITY TO

966
00:44:06,680 --> 00:44:08,160
SPEAK WITH YOU ALL TODAY.

967
00:44:08,160 --> 00:44:09,640
I WANT TO REMIND THE BOARD

968
00:44:09,640 --> 00:44:11,680
MEMBERS AS I ALWAYS DO THERE'S A

969
00:44:11,680 --> 00:44:13,600
DETAILED LEGISLATIVE UPDATE IN

970
00:44:13,600 --> 00:44:14,160
YOUR MEETING MATERIALS.

971
00:44:14,160 --> 00:44:15,640
THE TIME I HAVE TODAY I'M GOING

972
00:44:15,640 --> 00:44:20,040
TO COVER SOME MAJOR TOPICS

973
00:44:20,040 --> 00:44:21,280
BRIEFLY BUT THERE'S MORE DETAIL

974
00:44:21,280 --> 00:44:22,000
IN THE UPDATE.

975
00:44:22,000 --> 00:44:26,720
MY TEAM ARE GLAD TO TALK WITH

976
00:44:26,720 --> 00:44:28,480
YOU OR STAFF SO REACH OUT WITH

977
00:44:28,480 --> 00:44:28,720
QUESTIONS.

978
00:44:28,720 --> 00:44:29,320
NEXT SLIDE PLEASE.

979
00:44:29,320 --> 00:44:31,080
AS I THINK YOU'RE ALL AWARE THE

980
00:44:31,080 --> 00:44:33,960
FISCAL YEAR ENDS IN LESS THAN A

981
00:44:33,960 --> 00:44:34,160
MONTH.

982
00:44:34,160 --> 00:44:37,200
WE'RE PREPARING FOR A CONTINUING

983
00:44:37,200 --> 00:44:38,080
RESOLUTION, A C.R.

984
00:44:38,080 --> 00:44:41,520
I WANT TO TELL YOU WE DO NOT

985
00:44:41,520 --> 00:44:42,880
ANTICIPATE A GOVERNMENT

986
00:44:42,880 --> 00:44:43,680
SHUTDOWN.

987
00:44:43,680 --> 00:44:45,240
IT IS ALWAYS UNPOPULAR,

988
00:44:45,240 --> 00:44:46,920
POLITICALLY RISKY, EVEN MORE SO

989
00:44:46,920 --> 00:44:47,920
DURING AN ELECTION YEAR.

990
00:44:47,920 --> 00:44:49,640
THAT DOESN'T MEAN THAT IT'S NOT

991
00:44:49,640 --> 00:44:52,800
GOING TO BE LAST MINUTE BEFORE A

992
00:44:52,800 --> 00:44:54,320
C.R. IS IN PLACE, THAT'S

993
00:44:54,320 --> 00:44:55,760
BUSINESS AS USUAL FOR CONGRESS.

994
00:44:55,760 --> 00:44:57,480
I WANTED TO SHOW YOU THIS

995
00:44:57,480 --> 00:44:59,520
GRAPHIC, I'VE SHOWN IT BEFORE.

996
00:44:59,520 --> 00:45:00,520
IF YOU'LL INDULGE ME IT

997
00:45:00,520 --> 00:45:02,160
REPRESENTS THE BIG PICTURE OF

998
00:45:02,160 --> 00:45:03,800
HOW NCI RECEIVES ITS FUNDING AS

999
00:45:03,800 --> 00:45:05,760
PART OF THE FEDERAL BUDGET

1000
00:45:05,760 --> 00:45:06,400
PROCESS.

1001
00:45:06,400 --> 00:45:07,880
SO, AFTER THE PRESIDENT'S BUDGET

1002
00:45:07,880 --> 00:45:09,760
IS RELEASED, PROPOSAL FOR THE

1003
00:45:09,760 --> 00:45:11,800
FOLLOWING FISCAL YEAR, PRESIDENT

1004
00:45:11,800 --> 00:45:14,640
BIDEN RELEASED HIS FY23 PROPOSAL

1005
00:45:14,640 --> 00:45:16,400
IN LATE MARCH.

1006
00:45:16,400 --> 00:45:18,200
THEN CONGRESS HOLDS HEARINGS IN

1007
00:45:18,200 --> 00:45:20,640
STEP 2, BEGIN WORK ON PREPARING

1008
00:45:20,640 --> 00:45:22,640
SPENDING BILLS, AGENCY HEADS AND

1009
00:45:22,640 --> 00:45:23,720
DEPARTMENT HEADS TESTIFY.

1010
00:45:23,720 --> 00:45:25,640
THE NIH BUDGET HEARINGS WERE IN

1011
00:45:25,640 --> 00:45:28,320
MAY OF THIS YEAR.

1012
00:45:28,320 --> 00:45:31,920
THE RED X REPRESENTS WHERE WE

1013
00:45:31,920 --> 00:45:32,480
CURRENTLY ARE.

1014
00:45:32,480 --> 00:45:33,920
I SHOWED THIS IN JUNE.

1015
00:45:33,920 --> 00:45:36,200
WE WERE IN THE SAME SPOT THEN.

1016
00:45:36,200 --> 00:45:39,360
IDEALLY STEP 3 WHERE THE

1017
00:45:39,360 --> 00:45:40,280
APPROPRIATIONS COMMITTEES

1018
00:45:40,280 --> 00:45:42,120
CONFERENCE AND HAVE BIPARTISAN

1019
00:45:42,120 --> 00:45:43,000
NEGOTIATIONS, THEY FINALIZE

1020
00:45:43,000 --> 00:45:44,520
SPENDING BILLS, AND THEY ARE

1021
00:45:44,520 --> 00:45:46,520
ABLE TO BE READY TO BE ENACTED,

1022
00:45:46,520 --> 00:45:48,680
THAT HAPPENS IN THE SUMMER

1023
00:45:48,680 --> 00:45:49,640
IDEALLY AND WE CAN GET

1024
00:45:49,640 --> 00:45:50,880
APPROPRIATION BEFORE THE START

1025
00:45:50,880 --> 00:45:52,560
OF THE FISCAL YEAR.

1026
00:45:52,560 --> 00:45:54,040
IN REALITY, THIS ALMOST NEVER

1027
00:45:54,040 --> 00:45:54,840
HAPPENS.

1028
00:45:54,840 --> 00:45:58,720
IT'S HAPPENED IN THE PAST 26 

1029
00:45:58,720 --> 00:46:00,480
YEARS, IT'S HAPPENED TWICE, FOR

1030
00:46:00,480 --> 00:46:01,280
NIH.

1031
00:46:01,280 --> 00:46:03,440
IN 1996 AND IN 2018.

1032
00:46:03,440 --> 00:46:06,080
IN 2018, IT HAPPENED BECAUSE OUR

1033
00:46:06,080 --> 00:46:08,760
FY 19 BILL WAS PAIRED WITH THE

1034
00:46:08,760 --> 00:46:10,680
DEFENSE BILL SO THAT REALLY

1035
00:46:10,680 --> 00:46:12,760
RECRUITED ALL THE MEMBERS WHO

1036
00:46:12,760 --> 00:46:15,920
WANTED TO VOTE FOR DEFENSE BUT

1037
00:46:15,920 --> 00:46:17,640
NOT LABOR H HAD NO CHOICE, THAT

1038
00:46:17,640 --> 00:46:19,600
SPARED US FROM BEING PART OF THE

1039
00:46:19,600 --> 00:46:21,400
LONGEST GOVERNMENT SHUTDOWN IN

1040
00:46:21,400 --> 00:46:21,800
HISTORY.

1041
00:46:21,800 --> 00:46:22,680
MANY PARTS OF THE FEDERAL

1042
00:46:22,680 --> 00:46:24,040
GOVERNMENT WERE SHUT DOWN FOR AN

1043
00:46:24,040 --> 00:46:25,600
EXTENDED PERIOD OF TIME AND WE

1044
00:46:25,600 --> 00:46:27,520
WERE VERY GRATEFUL TO HAVE

1045
00:46:27,520 --> 00:46:28,080
AVOIDED THAT.

1046
00:46:28,080 --> 00:46:32,080
SO WHAT YOU NEED TO UNDERSTAND

1047
00:46:32,080 --> 00:46:33,880
THERE'S VIRTUALLY NO CHANCE OF

1048
00:46:33,880 --> 00:46:35,160
APPROPRIATIONS BEING COMPLETED

1049
00:46:35,160 --> 00:46:37,080
BEFORE THE MIDTERM ELECTIONS IN

1050
00:46:37,080 --> 00:46:38,240
NOVEMBER.

1051
00:46:38,240 --> 00:46:38,840
PROBABLY WELL INTO DECEMBER,

1052
00:46:38,840 --> 00:46:42,920
HOPEFULLY NOT TOO MUCH LONGER

1053
00:46:42,920 --> 00:46:43,760
THAN THAT.

1054
00:46:43,760 --> 00:46:45,960
IT IS NOT LIKELY BUT NOT

1055
00:46:45,960 --> 00:46:46,960
IMPOSSIBLE APPROPRIATIONS COULD

1056
00:46:46,960 --> 00:46:48,160
BE PUNTED INTO THE NEXT

1057
00:46:48,160 --> 00:46:48,800
CONGRESS.

1058
00:46:48,800 --> 00:46:50,440
I THINK THIS IS UNLIKELY FOR A

1059
00:46:50,440 --> 00:46:52,000
FEW REASONS.

1060
00:46:52,000 --> 00:46:53,080
ONE IS THERE'S STRONG MOTIVATION

1061
00:46:53,080 --> 00:46:55,040
TO GET THIS DONE IN THIS

1062
00:46:55,040 --> 00:46:57,440
CONGRESS FOR THE RETIRING

1063
00:46:57,440 --> 00:46:59,600
MEMBERS, SEVERAL SENIOR

1064
00:46:59,600 --> 00:47:01,080
APPROPRIATORS RETIRING IN THE

1065
00:47:01,080 --> 00:47:04,360
SENATE, SENATOR ROY BLUNT

1066
00:47:04,360 --> 00:47:05,760
RANKING MEMBER, RICHARD SHELBY

1067
00:47:05,760 --> 00:47:07,160
FROM ALABAMA THE RANKING MEMBER

1068
00:47:07,160 --> 00:47:09,480
OF THE FULL COMMITTEE, AND

1069
00:47:09,480 --> 00:47:10,440
SENATOR PATRICK LEAHY, CHAIR OF

1070
00:47:10,440 --> 00:47:11,000
THE FULL COMMITTEE.

1071
00:47:11,000 --> 00:47:13,200
THEY WOULD LIKE TO GET THEIR

1072
00:47:13,200 --> 00:47:14,120
EARMARKS INTO THESE BILLS, GET

1073
00:47:14,120 --> 00:47:15,320
THEM DONE AND PUT THEIR MARK ON

1074
00:47:15,320 --> 00:47:17,640
THIS AS THEY HAVE BEEN DOING

1075
00:47:17,640 --> 00:47:18,800
THIS WORK FOR DECADES.

1076
00:47:18,800 --> 00:47:20,560
ON THIS NEXT SLIDE THESE ARE

1077
00:47:20,560 --> 00:47:22,800
SOME PHOTOS FROM OUR

1078
00:47:22,800 --> 00:47:24,160
APPROPRIATIONS HEARINGS IN MAY.

1079
00:47:24,160 --> 00:47:28,880
ON THE LEFT DR. LOWY TESTIFIED

1080
00:47:28,880 --> 00:47:31,960
REPRESENTING NCI AT THE MAY

1081
00:47:31,960 --> 00:47:34,360
HEARING IN THE HOUSE.

1082
00:47:34,360 --> 00:47:35,640
CHAIRMAN DELAURO WANTED TO MAKE

1083
00:47:35,640 --> 00:47:38,080
A POINT, THEY CONTINUED THE FY

1084
00:47:38,080 --> 00:47:39,160
22 OMNIBUS A FEW WEEKS BEFORE

1085
00:47:39,160 --> 00:47:40,080
THIS HEARING AND SHE WANTED TO

1086
00:47:40,080 --> 00:47:42,000
MAKE THE POINT THEY WERE ABLE TO

1087
00:47:42,000 --> 00:47:45,520
COME TOGETHER AND INCREASE THE

1088
00:47:45,520 --> 00:47:46,920
NCI BUDGET BY $353 MILLION,

1089
00:47:46,920 --> 00:47:48,320
WE'RE VERY FORTUNATE THESE

1090
00:47:48,320 --> 00:47:51,160
MEMBERS HAVE TAKEN A PERSONAL

1091
00:47:51,160 --> 00:47:52,320
INTEREST IN CANCER RESEARCH.

1092
00:47:52,320 --> 00:47:55,080
THEY HAVE COME TOGETHER EVEN IN

1093
00:47:55,080 --> 00:47:57,440
VERY PARTISAN TIMES TO SUPPORT

1094
00:47:57,440 --> 00:47:59,600
INCREASES FOR NIH AND NCI, A

1095
00:47:59,600 --> 00:48:00,800
GREAT BENEFIT TO US.

1096
00:48:00,800 --> 00:48:03,360
THE PICTURES ON THE RIGHT SHOW

1097
00:48:03,360 --> 00:48:05,240
ACTING NIH DIRECTOR DR. LARRY

1098
00:48:05,240 --> 00:48:06,360
TABAK AND NIAID DIRECTOR DR.

1099
00:48:06,360 --> 00:48:08,120
TONY FAUCI AT THE SENATE

1100
00:48:08,120 --> 00:48:09,040
HEARING.

1101
00:48:09,040 --> 00:48:10,600
THE COUNTERPARTS IN THE SENATE

1102
00:48:10,600 --> 00:48:12,240
CHAIRWOMAN PATTY MURRAY OF

1103
00:48:12,240 --> 00:48:18,400
WASHINGTON STATE AND SENATOR ROY

1104
00:48:18,400 --> 00:48:22,200
BLUNT RANKING MEMBER OF MISSOURI

1105
00:48:22,200 --> 00:48:26,960
AR COLLEGIAL AND HAD A SHARED

1106
00:48:26,960 --> 00:48:27,200
PLIGHTER.

1107
00:48:27,200 --> 00:48:30,440
I LIKE THIS PICTURE.

1108
00:48:30,440 --> 00:48:33,080
OVER THE TIME THEY HAVE GOTTEN

1109
00:48:33,080 --> 00:48:35,880
TO KNOW HIM PERSONALLY, KNEW DR.

1110
00:48:35,880 --> 00:48:39,280
SHARPLESS, WE'RE LOOKING FORWARD

1111
00:48:39,280 --> 00:48:40,440
TO INTRODUCING DR. BERTAGNOLLI.

1112
00:48:40,440 --> 00:48:42,720
IT'S GREAT TO HAVE DIRECT

1113
00:48:42,720 --> 00:48:43,200
COMMUNICATION.

1114
00:48:43,200 --> 00:48:44,800
WE'RE ABLE TO UNDERSTAND THEIR

1115
00:48:44,800 --> 00:48:46,440
CONCERNS AND BE RESPONSIVE TO

1116
00:48:46,440 --> 00:48:49,120
QUESTIONS THEY HAVE.

1117
00:48:49,120 --> 00:48:50,080
NEXT SLIDE PLEASE.

1118
00:48:50,080 --> 00:48:52,720
SO WHAT I WANT TO SHOW HERE,

1119
00:48:52,720 --> 00:48:53,960
BEFORE I START TALKING ABOUT THE

1120
00:48:53,960 --> 00:48:55,720
NUMBERS I WANT TO BE CLEAR ABOUT

1121
00:48:55,720 --> 00:48:57,360
WHAT THESE MEAN AND WHAT THEY

1122
00:48:57,360 --> 00:48:58,040
DON'T MEAN.

1123
00:48:58,040 --> 00:49:00,000
THESE NUMBERS THAT I'M GOING TO

1124
00:49:00,000 --> 00:49:05,080
SHOW YOU DO NOT REFLECT

1125
00:49:05,080 --> 00:49:06,160
BIPARTISAN NEGOTIATED SPENDING

1126
00:49:06,160 --> 00:49:06,400
PROPOSALS.

1127
00:49:06,400 --> 00:49:08,760
AND THAT'S NOT TO SAY THIS IS

1128
00:49:08,760 --> 00:49:09,720
NOT AN IMPORTANT START, AN

1129
00:49:09,720 --> 00:49:12,280
IMPORTANT PART OF THE PROGRESS,

1130
00:49:12,280 --> 00:49:14,440
BUT SERIOUS NEGOTIATIONS ABOUT

1131
00:49:14,440 --> 00:49:16,640
FY23 WON'T REALLY START UNTIL

1132
00:49:16,640 --> 00:49:17,640
AFTER THE MIDTERMS AND

1133
00:49:17,640 --> 00:49:19,880
LEADERSHIP ON BOTH SIDES OF THE

1134
00:49:19,880 --> 00:49:21,480
AISLE KNOW WHAT HANDS THEY ARE

1135
00:49:21,480 --> 00:49:22,000
PLAYING.

1136
00:49:22,000 --> 00:49:24,440
THE PARTIES HAVE ALSO NOT

1137
00:49:24,440 --> 00:49:26,680
ADDRESSED THE BIGGEST THRESHOLD

1138
00:49:26,680 --> 00:49:28,800
ISSUE THIS YEAR AND LAST YEAR,

1139
00:49:28,800 --> 00:49:29,920
FUNDING FOR DEFENSE VERSUS

1140
00:49:29,920 --> 00:49:30,240
NON-DEFENSE.

1141
00:49:30,240 --> 00:49:32,640
THIS IS A TOP LINE

1142
00:49:32,640 --> 00:49:33,080
DETERMINATION.

1143
00:49:33,080 --> 00:49:34,800
IT WAS A BIG OBSTACLE TO THE

1144
00:49:34,800 --> 00:49:37,040
PRESSES LAST YEAR.

1145
00:49:37,040 --> 00:49:38,000
WASN'T RESOLVED UNTIL FEBRUARY.

1146
00:49:38,000 --> 00:49:39,600
HOPEFULLY IT WON'T TAKE THAT

1147
00:49:39,600 --> 00:49:40,400
LONG THIS YEAR.

1148
00:49:40,400 --> 00:49:43,240
BUT I WILL SAY LAST YEAR WHEN IT

1149
00:49:43,240 --> 00:49:45,600
WAS RESOLVED THE OMNIBUS WAS

1150
00:49:45,600 --> 00:49:47,280
COMPLETED AND ENACTED WITHIN SIX

1151
00:49:47,280 --> 00:49:47,640
WEEKS.

1152
00:49:47,640 --> 00:49:51,560
SO ONCE THAT DOMINO FELL, THINGS

1153
00:49:51,560 --> 00:49:52,120
PROGRESSED QUICKLY.

1154
00:49:52,120 --> 00:49:54,480
ALSO LIKE LAST YEAR, THERE ARE

1155
00:49:54,480 --> 00:50:01,560
EVERGREEN POLICY DISPUTES ABOUT 

1156
00:50:01,560 --> 00:50:02,160
IMMIGRATION, BORDER SECURITY,

1157
00:50:02,160 --> 00:50:03,080
IMMIGRATION, PLAYING OUT WHEN

1158
00:50:03,080 --> 00:50:04,520
THE SIDES BEGIN TO NEGOTIATE.

1159
00:50:04,520 --> 00:50:06,920
SO LOOKING AT THESE NUMBERS, THE

1160
00:50:06,920 --> 00:50:07,840
HOUSE HAD THE VOTES TO MOVE

1161
00:50:07,840 --> 00:50:09,320
THEIR BILLS OUT OF COMMITTEE.

1162
00:50:09,320 --> 00:50:10,280
THEY HAVE SLIGHTLY LARGER

1163
00:50:10,280 --> 00:50:12,360
MARGINS THAN THE SENATE.

1164
00:50:12,360 --> 00:50:13,240
SO THE APPROPRIATIONS COMMITTEES

1165
00:50:13,240 --> 00:50:15,480
WERE ABLE TO PASS THESE BILLS

1166
00:50:15,480 --> 00:50:18,160
OUT OF COMMITTEE, WHAT THEY

1167
00:50:18,160 --> 00:50:19,440
PROPOSED WAS A $466 MILLION

1168
00:50:19,440 --> 00:50:20,840
INCREASE FOR THE NCI.

1169
00:50:20,840 --> 00:50:24,320
WE WERE VERY GRATEFUL TO SEE

1170
00:50:24,320 --> 00:50:24,520
THAT.

1171
00:50:24,520 --> 00:50:26,920
THE SENATE, 50-50 SENATE DID NOT

1172
00:50:26,920 --> 00:50:30,520
HAVE THOSE VOTES SO CHAIRMAN

1173
00:50:30,520 --> 00:50:31,840
LEAHY, SAME SITUATION, POSTED

1174
00:50:31,840 --> 00:50:33,040
DRAFT BILLS, REFLECTING THE

1175
00:50:33,040 --> 00:50:34,800
MAJORITY VIEWPOINT IN THE

1176
00:50:34,800 --> 00:50:35,040
SENATE.

1177
00:50:35,040 --> 00:50:36,920
AND IT'S THE MAJORITY

1178
00:50:36,920 --> 00:50:38,320
PREROGATIVE TO DO THIS.

1179
00:50:38,320 --> 00:50:40,080
WHAT WE SAW WHEN THE SENATE BILL

1180
00:50:40,080 --> 00:50:43,160
WAS POSTED IN LATE JULY WAS

1181
00:50:43,160 --> 00:50:44,720
PROPOSED $290 MILLION INCREASE

1182
00:50:44,720 --> 00:50:46,040
FOR THE NCI.

1183
00:50:46,040 --> 00:50:48,000
SO, THESE NUMBERS ARE REALLY

1184
00:50:48,000 --> 00:50:49,200
IMPORTANT INDICATORS ABOUT WHERE

1185
00:50:49,200 --> 00:50:51,440
THE CONVERSATION IS GOING TO

1186
00:50:51,440 --> 00:50:54,200
START WHEN THEY BEGIN

1187
00:50:54,200 --> 00:50:54,640
NEGOTIATIONS.

1188
00:50:54,640 --> 00:50:55,920
NEXT SLIDE PLEASE.

1189
00:50:55,920 --> 00:50:59,320
SO I KNOW THERE'S A LOT OF

1190
00:50:59,320 --> 00:51:00,320
INTEREST IN ARPA-H, STILL EARLY

1191
00:51:00,320 --> 00:51:01,880
STAGES, THERE MAY BE MORE

1192
00:51:01,880 --> 00:51:02,960
QUESTIONS THAN ANSWERS.

1193
00:51:02,960 --> 00:51:04,800
BUT I THOUGHT IT WOULD BE

1194
00:51:04,800 --> 00:51:06,560
HELPFUL TO POINT THE BOARD TO

1195
00:51:06,560 --> 00:51:07,760
THE MOST RECENT PRESENTATION,

1196
00:51:07,760 --> 00:51:10,200
THIS IS THE MOST COMPREHENSIVE

1197
00:51:10,200 --> 00:51:13,560
INFORMATION THAT WE HAVE.

1198
00:51:13,560 --> 00:51:14,160
DR. TARA SCHWETZ PRESENTED AT

1199
00:51:14,160 --> 00:51:16,200
THE ADVISORY COMMITTEE TO THE

1200
00:51:16,200 --> 00:51:18,360
DIRECTOR IN JUNE.

1201
00:51:18,360 --> 00:51:19,480
AND INTERESTING PRESENTATION,

1202
00:51:19,480 --> 00:51:21,160
AND THE DISCUSSION WAS

1203
00:51:21,160 --> 00:51:22,240
ILLUMINATING I THINK.

1204
00:51:22,240 --> 00:51:24,440
I THOUGHT WE WOULD FOCUS ON WHAT

1205
00:51:24,440 --> 00:51:26,280
WE DO KNOW.

1206
00:51:26,280 --> 00:51:28,440
ARPA-H RECEIVED $1 BILLION

1207
00:51:28,440 --> 00:51:33,000
APPROPRIATION IN FY 22 OMNIBUS,

1208
00:51:33,000 --> 00:51:35,280
INCLUDED WAS AUTHORIZATION FOR

1209
00:51:35,280 --> 00:51:38,280
THE HHS SECRETARY TO TRANSFER

1210
00:51:38,280 --> 00:51:40,920
ARPA-H ANYWHERE WITHIN HHS, AND

1211
00:51:40,920 --> 00:51:41,520
SPECIFICALLY NOTED INCLUDING

1212
00:51:41,520 --> 00:51:41,800
NIH.

1213
00:51:41,800 --> 00:51:43,480
AND THAT IS WHAT HE DID.

1214
00:51:43,480 --> 00:51:46,520
HE DID THAT IN APRIL.

1215
00:51:46,520 --> 00:51:50,040
SO, I THINK PEOPLE ARE PROBABLY

1216
00:51:50,040 --> 00:51:54,360
PRETTY WELL AWARE THAT THERE IS

1217
00:51:54,360 --> 00:51:56,480
AUTHORIZING LEGISLATION THAT

1218
00:51:56,480 --> 00:51:58,200
REALLY REFLECTS SORT OF A

1219
00:51:58,200 --> 00:51:59,600
DISAGREEMENT WITHIN THE

1220
00:51:59,600 --> 00:52:01,200
SCIENTIFIC COMMUNITY, A LARGER

1221
00:52:01,200 --> 00:52:03,560
DEBATE WHERE SHOULD ARPA-H BE

1222
00:52:03,560 --> 00:52:04,600
AND INTERACT WITHIN NIH, IS IT

1223
00:52:04,600 --> 00:52:05,120
IMPORTANT IT'S OUTSIDE THE

1224
00:52:05,120 --> 00:52:09,840
STRUCK YOU  -- STRUCTURE OF NIH

1225
00:52:09,840 --> 00:52:11,800
AGENCY OR CAN IT WORK

1226
00:52:11,800 --> 00:52:13,440
INDEPENDENTLY AND MAINTAIN THIS

1227
00:52:13,440 --> 00:52:14,400
WAY OF OPERATION.

1228
00:52:14,400 --> 00:52:15,960
I DON'T KNOW THE ANSWERS, I'M

1229
00:52:15,960 --> 00:52:18,160
NOT SURE IF THERE'S GOING TO BE

1230
00:52:18,160 --> 00:52:18,800
AUTHORIZING LEGISLATION.

1231
00:52:18,800 --> 00:52:21,680
THERE'S THREE BILLS.

1232
00:52:21,680 --> 00:52:23,640
ONE HAS PASSED THE HOUSE, ONE

1233
00:52:23,640 --> 00:52:25,080
INTRODUCED IN THE HOUSE, ONE

1234
00:52:25,080 --> 00:52:27,000
INTRODUCED IN THE SENATE.

1235
00:52:27,000 --> 00:52:28,160
THESE ARE PENDING.

1236
00:52:28,160 --> 00:52:28,960
THEY HAVE DIFFERENT APPROACHES.

1237
00:52:28,960 --> 00:52:33,240
THE ONE IN THE HOUSE THAT PASSED

1238
00:52:33,240 --> 00:52:35,440
THAT IS SPONSORED BY ANNA ESCHEW

1239
00:52:35,440 --> 00:52:36,880
OF CALIFORNIA WOULD PUT ARPA-H

1240
00:52:36,880 --> 00:52:40,800
IN HHS BUT NOT WITHIN NIH.

1241
00:52:40,800 --> 00:52:42,120
SENATE BILL INTRODUCED BY

1242
00:52:42,120 --> 00:52:50,040
SENATOR PATTY MURRAY AND RICHARD

1243
00:52:50,040 --> 00:52:52,320
BURR OF NORTH CAROLINA PREVENT

1244
00:52:52,320 --> 00:52:55,040
IT IN BEING LOCATE IN THE D.C.

1245
00:52:55,040 --> 00:52:57,360
AREA, IN THE NIH, PROHIBITED

1246
00:52:57,360 --> 00:52:58,560
FROM HIGHING ANYONE EMPLOYED BY

1247
00:52:58,560 --> 00:53:01,440
NIH IN THE PRIOR THREE YEARS.

1248
00:53:01,440 --> 00:53:03,280
WE DON'T KNOW WHAT'S GOING TO

1249
00:53:03,280 --> 00:53:04,600
HAPPEN OR WHO THE DIRECTOR WILL

1250
00:53:04,600 --> 00:53:04,800
BE.

1251
00:53:04,800 --> 00:53:05,880
THERE'S A LOT OF INTEREST IN

1252
00:53:05,880 --> 00:53:08,440
FIGURING OUT WHO WILL BE

1253
00:53:08,440 --> 00:53:09,400
APPOINTED TO LEAD THIS

1254
00:53:09,400 --> 00:53:09,720
ORGANIZATION.

1255
00:53:09,720 --> 00:53:11,280
IN MAY THERE WAS APPOINTMENT OF

1256
00:53:11,280 --> 00:53:13,920
DR. ADAM RUSSELL AS ACTING

1257
00:53:13,920 --> 00:53:14,880
DEPUTY DIRECTOR.

1258
00:53:14,880 --> 00:53:17,000
ONE OTHER THING I WANTED TO KNOW

1259
00:53:17,000 --> 00:53:18,760
ABOUT THE $1 BILLION

1260
00:53:18,760 --> 00:53:20,360
APPROPRIATION THAT ARPA-H

1261
00:53:20,360 --> 00:53:23,240
RECEIVED IN FY 22 THAT WAS GIVEN

1262
00:53:23,240 --> 00:53:24,880
TO THEM WITH THREE-YEAR BUDGET

1263
00:53:24,880 --> 00:53:27,080
AUTHORITY SO THEY CAN SPENT THAT

1264
00:53:27,080 --> 00:53:30,160
MONEY IN FY 22, 23, AND 24.

1265
00:53:30,160 --> 00:53:30,760
REALLY HELPFUL FLEXIBILITY FOR

1266
00:53:30,760 --> 00:53:35,240
THEM AS THEY ARE JUST GETTING

1267
00:53:35,240 --> 00:53:37,360
STARTED.

1268
00:53:37,360 --> 00:53:38,520
NEXT SLIDE PLEASE.

1269
00:53:38,520 --> 00:53:39,800
CAPITOL HILL IS A GHOST TOWN IN

1270
00:53:39,800 --> 00:53:45,720
AUGUST BUT NOT THIS YEAR.

1271
00:53:45,720 --> 00:53:49,280
ADMINISTRATION AND CONGRESSIONAL

1272
00:53:49,280 --> 00:53:51,160
DEMOCRATS HAD A GOOD AUGUST,

1273
00:53:51,160 --> 00:53:52,920
ADVANCING ALONG PARTY LINE

1274
00:53:52,920 --> 00:53:54,400
VOTES, THE FIRST CHIPS IN

1275
00:53:54,400 --> 00:53:56,160
SCIENCE ACT, YOU'VE HEARD OF

1276
00:53:56,160 --> 00:53:57,440
THIS WITH MANY NAMES.

1277
00:53:57,440 --> 00:54:00,640
IT STARTED TWO YEARS AGO BEING

1278
00:54:00,640 --> 00:54:02,920
CALLED THE ENDLESS FRONTIERS

1279
00:54:02,920 --> 00:54:03,320
ACT.

1280
00:54:03,320 --> 00:54:05,880
CHIPS IN SCIENCE ACT WILL INVEST

1281
00:54:05,880 --> 00:54:08,520
$52 BILLION IN U.S. PRODUCTION

1282
00:54:08,520 --> 00:54:11,760
OF SEMICONDUCTOR CHIPS AND

1283
00:54:11,760 --> 00:54:13,880
AUTHORIZED NOT APPROPRIATES A

1284
00:54:13,880 --> 00:54:16,520
FIVE-YEAR $81 BILLION INCREASE

1285
00:54:16,520 --> 00:54:17,280
IN FUNDING FOR THE NATIONAL

1286
00:54:17,280 --> 00:54:19,280
SCIENCE FOUNDATION.

1287
00:54:19,280 --> 00:54:21,680
INFLATION REDUCTION ACT ENACTED

1288
00:54:21,680 --> 00:54:24,600
AUGUST 16 IS REALLY ADVANCES IN

1289
00:54:24,600 --> 00:54:26,360
KEY DOMESTIC PRIORITIES FOR THE

1290
00:54:26,360 --> 00:54:27,480
ADMINISTRATION, HEALTH CARE,

1291
00:54:27,480 --> 00:54:28,800
ALLOWS MEDICARE TO NEGOTIATE

1292
00:54:28,800 --> 00:54:31,280
PRICES FOR SOME PRESCRIPTION

1293
00:54:31,280 --> 00:54:32,800
DRUGS, INVESTS IN CLIMATE CHANGE

1294
00:54:32,800 --> 00:54:34,680
AND CLEAN ENERGY, A REALLY

1295
00:54:34,680 --> 00:54:37,800
IMPORTANT PROVISION TO WORK TRUE

1296
00:54:37,800 --> 00:54:41,600
AND GET SENATOR MANCHIN'S

1297
00:54:41,600 --> 00:54:43,520
SUPPORT TO GET THROUGH THE

1298
00:54:43,520 --> 00:54:45,120
SENATE AND TAX OVERALL

1299
00:54:45,120 --> 00:54:45,880
PROVISION, TAXES FOR

1300
00:54:45,880 --> 00:54:46,640
CORPORATIONS, A BIG VICTORY.

1301
00:54:46,640 --> 00:54:50,160
THEY HAVE A LOT MORE WORK TO DO

1302
00:54:50,160 --> 00:54:51,280
THOUGH.

1303
00:54:51,280 --> 00:54:52,680
THERE ARE SOME MUST-PASS PIECES

1304
00:54:52,680 --> 00:54:53,560
OF LEGISLATION THAT HAVE TO BE

1305
00:54:53,560 --> 00:54:58,200
DEALT WITH IN THE NEXT MONTH.

1306
00:54:58,200 --> 00:54:59,520
THE USER FEES AUTHORIZATION FOR

1307
00:54:59,520 --> 00:55:02,160
FDA IS EXPIRING BY THE END OF

1308
00:55:02,160 --> 00:55:03,320
THE MONTH.

1309
00:55:03,320 --> 00:55:05,720
ALSO THE AUTHORIZATION FOR THE

1310
00:55:05,720 --> 00:55:07,360
SMALL BUSINESS INNOVATION

1311
00:55:07,360 --> 00:55:08,840
RESEARCH PROGRAM, AND NATIONAL

1312
00:55:08,840 --> 00:55:10,000
DEFENSE ANNUAL AUTHORIZATION.

1313
00:55:10,000 --> 00:55:11,400
SO WE EXPECT TO SEE ACTION ON

1314
00:55:11,400 --> 00:55:14,400
ALL OF THOSE BILLS IN THE NEXT

1315
00:55:14,400 --> 00:55:15,400
MONTH.

1316
00:55:15,400 --> 00:55:17,240
OTHER LEGISLATION WE'RE WATCHING

1317
00:55:17,240 --> 00:55:18,760
INCLUDES THERE WAS PANDEMIC

1318
00:55:18,760 --> 00:55:21,440
PREPAREDNESS LEGISLATION IN THE

1319
00:55:21,440 --> 00:55:22,800
SENATE, OBVIOUSLY ARPA-H

1320
00:55:22,800 --> 00:55:24,520
AUTHORIZATION, THERE WAS ALSO

1321
00:55:24,520 --> 00:55:25,200
COVID SUPPLEMENTAL BILL

1322
00:55:25,200 --> 00:55:26,960
INTRODUCED IN THE SENATE IN

1323
00:55:26,960 --> 00:55:27,200
JULY.

1324
00:55:27,200 --> 00:55:28,240
WE DON'T KNOW WHAT'S HAPPENING

1325
00:55:28,240 --> 00:55:30,800
WITH THAT OR WHAT MIGHT HAPPEN.

1326
00:55:30,800 --> 00:55:32,880
WE'VE SEEN REAL INTEREST IN THIS

1327
00:55:32,880 --> 00:55:34,280
CONGRESS, I'M SURE YOU'RE AWARE,

1328
00:55:34,280 --> 00:55:35,600
IN TELEHEALTH.

1329
00:55:35,600 --> 00:55:37,560
THERE'S BEEN OVER 50 BILLS

1330
00:55:37,560 --> 00:55:38,200
INTRODUCED, WE'RE WATCHING

1331
00:55:38,200 --> 00:55:40,080
SEVERAL OF THE BILLS, THE ONE

1332
00:55:40,080 --> 00:55:41,640
WITH THE MOST SPONSORS IS THE

1333
00:55:41,640 --> 00:55:42,160
CONNECT ACT.

1334
00:55:42,160 --> 00:55:45,200
THERE'S A LOT OF INTEREST IN

1335
00:55:45,200 --> 00:55:47,400
CONTINUING AND EXPANDING

1336
00:55:47,400 --> 00:55:48,520
TELEHEALTH FLEXIBILITY, SOME

1337
00:55:48,520 --> 00:55:49,480
THINGS THAT BECAME REALLY WELL

1338
00:55:49,480 --> 00:55:51,040
UNDERSTOOD DURING THE FIRST TWO

1339
00:55:51,040 --> 00:55:52,680
YEARS OF THE PANDEMIC.

1340
00:55:52,680 --> 00:55:54,560
ALSO CONGRESS HAS BEGUN TO PAY A

1341
00:55:54,560 --> 00:55:57,600
LOT OF ATTENTION TO CLINICAL

1342
00:55:57,600 --> 00:55:58,880
TRIALS, TO ACCESS AND INCLUSION,

1343
00:55:58,880 --> 00:55:59,880
NOT JUST FOR CANCER CLINICAL

1344
00:55:59,880 --> 00:56:01,760
TRIALS, FOR ALL CLINICAL TRIALS.

1345
00:56:01,760 --> 00:56:02,680
SO WE'RE TRACKING SOME

1346
00:56:02,680 --> 00:56:04,720
LEGISLATION IN THOSE AREAS AND

1347
00:56:04,720 --> 00:56:08,280
THAT DETAIL IS IN THE UPDATE

1348
00:56:08,280 --> 00:56:08,520
DOCUMENT.

1349
00:56:08,520 --> 00:56:09,080
NEXT SLIDE PLEASE.

1350
00:56:09,080 --> 00:56:11,800
SO THIS IS THE CONGRESSIONAL

1351
00:56:11,800 --> 00:56:12,760
CALENDAR.

1352
00:56:12,760 --> 00:56:15,360
ALWAYS SUBJECT TO CHANGE.

1353
00:56:15,360 --> 00:56:16,960
THEY RETURN, SOME RETURN, ON THE

1354
00:56:16,960 --> 00:56:20,600
6th OF NEXT WEEK WITH THREE

1355
00:56:20,600 --> 00:56:22,240
WEEKS TO PASS A CONTINUING

1356
00:56:22,240 --> 00:56:23,760
RESOLUTION TO AVOID GOVERNMENT

1357
00:56:23,760 --> 00:56:25,200
SHUTDOWN AND ADDRESS MUST-PASS

1358
00:56:25,200 --> 00:56:28,240
LEGISLATION THAT I REFERENCED

1359
00:56:28,240 --> 00:56:28,840
EARLIER.

1360
00:56:28,840 --> 00:56:30,280
THERE'S REALLY ONLY 11 DAYS

1361
00:56:30,280 --> 00:56:32,640
BETWEEN THEM COMING BACK AND THE

1362
00:56:32,640 --> 00:56:34,160
NOVEMBER MIDTERMS THAT BOTH

1363
00:56:34,160 --> 00:56:35,480
CHAMBERS ARE IN SESSION.

1364
00:56:35,480 --> 00:56:36,720
THE SENATE MAY BE BACK IN

1365
00:56:36,720 --> 00:56:37,960
OCTOBER FOR THESE TWO WEEKS THAT

1366
00:56:37,960 --> 00:56:40,080
ARE SLATED ON THE CALENDAR.

1367
00:56:40,080 --> 00:56:41,880
REALLY ALL MEMBERS OF THE HOUSE

1368
00:56:41,880 --> 00:56:43,960
WHO ARE UP FOR REELECTION AND A

1369
00:56:43,960 --> 00:56:45,680
THIRD OF THE SENATE, THAT'S UP

1370
00:56:45,680 --> 00:56:46,960
FOR REELECTION, WOULD LIKE TO BE

1371
00:56:46,960 --> 00:56:48,880
CAMPAIGNING IN THEIR DISTRICTS

1372
00:56:48,880 --> 00:56:49,720
AND STATES.

1373
00:56:49,720 --> 00:56:52,520
BUT THERE ARE 90 PENDING

1374
00:56:52,520 --> 00:56:53,200
NOMINATIONS FOR THE

1375
00:56:53,200 --> 00:56:54,800
ADMINISTRATION, NOT ALL ON THE

1376
00:56:54,800 --> 00:56:56,400
ARE GOING TO MOVE BUT THEY MAY

1377
00:56:56,400 --> 00:56:58,120
COME BACK TO WORK ON NOMINATIONS

1378
00:56:58,120 --> 00:57:00,080
IF IT'S SOMETHING THEY CAN'T GET

1379
00:57:00,080 --> 00:57:00,840
TO IN SEPTEMBER.

1380
00:57:00,840 --> 00:57:02,040
BECAUSE THERE MAY BE SOME THAT

1381
00:57:02,040 --> 00:57:04,560
THEY WANT TO GET DONE BEFORE

1382
00:57:04,560 --> 00:57:04,960
MIDTERMS.

1383
00:57:04,960 --> 00:57:08,440
AND WE'LL SEE WHAT HAPPENS WITH

1384
00:57:08,440 --> 00:57:08,680
THAT.

1385
00:57:08,680 --> 00:57:09,680
NEXT SLIDE PLEASE.

1386
00:57:09,680 --> 00:57:12,200
SO HISTORY TELLS US THAT THE

1387
00:57:12,200 --> 00:57:14,360
PRESIDENT'S PARTY LOSES SEATS IN

1388
00:57:14,360 --> 00:57:15,320
THE MIDTERMS.

1389
00:57:15,320 --> 00:57:16,720
THIS COVERAGE IS ON EVERY NEWS

1390
00:57:16,720 --> 00:57:18,160
REPORT ABOUT WHAT'S GOING TO

1391
00:57:18,160 --> 00:57:19,200
HAPPEN IN THE ELECTIONS.

1392
00:57:19,200 --> 00:57:20,680
I THOUGHT IT WAS INTERESTING TO

1393
00:57:20,680 --> 00:57:22,600
LOOK AT THESE DATA THAT SHOW

1394
00:57:22,600 --> 00:57:26,560
THERE'S ONLY BEEN TWO EXCEPTIONS

1395
00:57:26,560 --> 00:57:29,640
SINCE 1946 TO THAT HISTORICAL

1396
00:57:29,640 --> 00:57:31,000
LESSON.

1397
00:57:31,000 --> 00:57:32,640
FIRST WAS PRESIDENT CLINTON'S

1398
00:57:32,640 --> 00:57:35,120
SECOND TERM DEMOCRATS PICKED UP

1399
00:57:35,120 --> 00:57:36,400
FIVE SEATS AND PRESIDENT GEORGE

1400
00:57:36,400 --> 00:57:37,560
BUSH'S FIRST TERM WHERE

1401
00:57:37,560 --> 00:57:38,920
REPUBLICANS PICKED UP EIGHT

1402
00:57:38,920 --> 00:57:39,120
SEATS.

1403
00:57:39,120 --> 00:57:40,320
THAT WAS RIGHT AFTER 9/11, AND

1404
00:57:40,320 --> 00:57:41,800
SO THAT'S MAYBE LESS OF AN

1405
00:57:41,800 --> 00:57:43,960
OUTLIER THAN IT WOULD APPEAR

1406
00:57:43,960 --> 00:57:44,640
HERE.

1407
00:57:44,640 --> 00:57:47,480
NOT ONLY DO ELECTIONS MATTER BUT

1408
00:57:47,480 --> 00:57:47,960
ALSO MAJORITIES MATTER.

1409
00:57:47,960 --> 00:57:49,960
IT'S MUCH EASIER TO MOVE YOUR

1410
00:57:49,960 --> 00:57:52,400
PARTY'S AGENDA IF YOU HAVE A

1411
00:57:52,400 --> 00:57:53,400
HEALTHY MAJORITY AS OPPOSED TO

1412
00:57:53,400 --> 00:57:55,560
ONE OF THE SLIMMEST MAJORITIES

1413
00:57:55,560 --> 00:57:57,080
IN HISTORY THAT SPEAKER PELOSI

1414
00:57:57,080 --> 00:57:58,200
HAS BEEN DEALING WITH IN THE

1415
00:57:58,200 --> 00:57:59,760
HOUSE OVER THE PAST TWO YEARS,

1416
00:57:59,760 --> 00:58:01,400
FOR EXAMPLE, WHEN YOU CAN ONLY

1417
00:58:01,400 --> 00:58:02,880
LOSE A HANDFUL OF VOTES IT'S A

1418
00:58:02,880 --> 00:58:04,760
BIG CHALLENGE TO KEEP YOUR

1419
00:58:04,760 --> 00:58:06,840
CAUCUS TOGETHER AND BE ABLE TO

1420
00:58:06,840 --> 00:58:07,840
MOVE LEGISLATION.

1421
00:58:07,840 --> 00:58:11,080
SO WE'RE ALL INTERESTED I THINK

1422
00:58:11,080 --> 00:58:11,840
POLITICAL JUNKIES ARE INTERESTED

1423
00:58:11,840 --> 00:58:12,960
TO SEE WHAT HAPPENS.

1424
00:58:12,960 --> 00:58:14,400
IT APPEARS AS THOUGH THE

1425
00:58:14,400 --> 00:58:15,360
REPUBLICANS ARE STILL FAVORED

1426
00:58:15,360 --> 00:58:16,560
THROUGH MOST OF THE POLLING,

1427
00:58:16,560 --> 00:58:18,680
I'VE BEEN READING, TO RETAKE THE

1428
00:58:18,680 --> 00:58:21,320
HOUSE BUT PERHAPS WITH FAR

1429
00:58:21,320 --> 00:58:23,000
SMALLER MAJORITIES THAN EXPECTED

1430
00:58:23,000 --> 00:58:24,120
SO THE MAGNITUDE OF THE SHIFT IS

1431
00:58:24,120 --> 00:58:26,560
GOING TO BE IMPORTANT AS WELL AS

1432
00:58:26,560 --> 00:58:29,240
THE SHIFT ITSELF.

1433
00:58:29,240 --> 00:58:29,800
NEXT SLIDE PLEASE.

1434
00:58:29,800 --> 00:58:33,120
I WANTED TO SHOW YOU MY LAST

1435
00:58:33,120 --> 00:58:34,400
SLIDE, TURNOUT WILL BE REALLY

1436
00:58:34,400 --> 00:58:40,480
IMPORTANT IN THESE MIDTERMS,

1437
00:58:40,480 --> 00:58:43,440
MUCH HIGHER IN 2018, A LOT OF

1438
00:58:43,440 --> 00:58:45,880
PEOPLE -- MANY MORE SHOW UP FOR

1439
00:58:45,880 --> 00:58:46,920
PRESIDENTIAL ELECTIONS THAN

1440
00:58:46,920 --> 00:58:47,960
MIDTERMS SO IT'S INTERESTING TO

1441
00:58:47,960 --> 00:58:50,880
LOOK AT THIS AND SEE, WE SAW

1442
00:58:50,880 --> 00:58:52,320
THIS REALLY BIG INCREASE FROM

1443
00:58:52,320 --> 00:58:59,440
2014 TO 2018 AND WE'LL SEE HOW

1444
00:58:59,440 --> 00:59:03,360
GALVANIZING SUPREME COURT EVENTS

1445
00:59:03,360 --> 00:59:04,640
HAVE BEEN, I'M HAPPY TO TAKE

1446
00:59:04,640 --> 00:59:07,320
QUESTIONS NOW OR OFFLINE.

1447
00:59:07,320 --> 00:59:09,440
REACH OUT, I WOULD LOVE TO HEAR

1448
00:59:09,440 --> 00:59:10,800
FROM YOU.

1449
00:59:10,800 --> 00:59:11,120
THANKS.

1450
00:59:11,120 --> 00:59:12,880
>> THANKS, M.K.

1451
00:59:12,880 --> 00:59:20,120
THE FLOOR IS NOW OPEN FOR

1452
00:59:20,120 --> 00:59:21,000
QUESTIONS.

1453
00:59:21,000 --> 00:59:22,480
I'LL TAKE THE CHAIR'S

1454
00:59:22,480 --> 00:59:23,560
PREROGATIVE WHILE WE WAIT FOR

1455
00:59:23,560 --> 00:59:24,320
OTHER QUESTIONS.

1456
00:59:24,320 --> 00:59:28,840
AS WE THINK ABOUT THE MOONSHOT,

1457
00:59:28,840 --> 00:59:34,040
WILL IT SORT OF BUDGETARILY

1458
00:59:34,040 --> 00:59:34,560
OPERATE UNDER PREVIOUS

1459
00:59:34,560 --> 00:59:35,560
LEGISLATION OR REQUIRE NO

1460
00:59:35,560 --> 00:59:38,680
LEGISLATION TO FUND IT?

1461
00:59:38,680 --> 00:59:40,920
>> IT WOULD REQUIRE -- IT

1462
00:59:40,920 --> 00:59:44,240
WOULDN'T HAVE TO BE NEW

1463
00:59:44,240 --> 00:59:44,840
AUTHORIZATIONING LEGISLATION,

1464
00:59:44,840 --> 00:59:47,120
COULD BE APPROPRIATIONS BILL BUT

1465
00:59:47,120 --> 00:59:50,160
1.0 MOONSHOT WAS AUTHORIZED BY

1466
00:59:50,160 --> 00:59:51,960
THE 21ST CENTURY CURES.

1467
00:59:51,960 --> 00:59:52,280
>> RIGHT.

1468
00:59:52,280 --> 00:59:54,280
>> AND THEN APPROPRIATED.

1469
00:59:54,280 --> 00:59:54,560
>> RIGHT.

1470
00:59:54,560 --> 00:59:57,040
>> YEAH, IF IT WAS GOING
TO BE

1471
00:59:57,040 --> 00:59:59,120
DONE IN THAT WAY, THROUGH --

1472
00:59:59,120 --> 01:00:02,000
THOSE WERE -- THEY CREATED

1473
01:00:02,000 --> 01:00:04,840
SET-ASIDES AND CREATED MANDATORY

1474
01:00:04,840 --> 01:00:05,560
FUNDING FOR THOSE PROGRAMS,

1475
01:00:05,560 --> 01:00:07,240
APPROPRIATORS CAN FUND NEW

1476
01:00:07,240 --> 01:00:09,440
PROJECTS AND INITIATIVES AND DO

1477
01:00:09,440 --> 01:00:10,000
FREQUENTLY.

1478
01:00:10,000 --> 01:00:11,840
BUT THAT WAS A DIFFERENT AND

1479
01:00:11,840 --> 01:00:13,600
SORT OF UNIQUE MODEL.

1480
01:00:13,600 --> 01:00:16,400
IT REALLY -- WE'LL SEE WHAT'S

1481
01:00:16,400 --> 01:00:18,000
PROPOSED FOR FY 24 BUT AS CAME

1482
01:00:18,000 --> 01:00:21,320
UP IN THE BUDGET SUBCOMMITTEE

1483
01:00:21,320 --> 01:00:22,840
HEARING, EARLIER IN DR. LOWY'S

1484
01:00:22,840 --> 01:00:24,440
PRESENTATION, I'M SORRY, THAT'S

1485
01:00:24,440 --> 01:00:26,640
A NEXT BUDGET YEAR LET'S SEE HOW

1486
01:00:26,640 --> 01:00:27,840
THEY HANDLING IT.

1487
01:00:27,840 --> 01:00:29,920
I CAN TELL YOU THERE'S AN

1488
01:00:29,920 --> 01:00:32,840
AWARENESS AMONG MEMBERS OF

1489
01:00:32,840 --> 01:00:33,920
APPROPRIATIONS STAFF AND

1490
01:00:33,920 --> 01:00:35,640
COMMITTEE MEMBERS THAT THIS END

1491
01:00:35,640 --> 01:00:37,200
OF THAT FUNDING IS COMING, AND

1492
01:00:37,200 --> 01:00:38,800
THAT THERE'S GOING TO HAVE TO BE

1493
01:00:38,800 --> 01:00:41,640
SOME CHOICES MADE AND WE WANT TO

1494
01:00:41,640 --> 01:00:45,640
CONTINUE THIS IMPORTANT WORK.

1495
01:00:45,640 --> 01:00:48,000
>> THANKS. 

1496
01:00:48,000 --> 01:00:50,400
I SEE CHRIS' HAND.

1497
01:00:50,400 --> 01:00:51,640
>> M.K., THANKS, AS
ALWAYS.

1498
01:00:51,640 --> 01:00:53,680
APPRECIATE YOUR TIME AND

1499
01:00:53,680 --> 01:00:54,440
THOUGHTFUL REPORT.

1500
01:00:54,440 --> 01:00:55,400
THIS IS PROBABLY MORE JUST TO

1501
01:00:55,400 --> 01:00:57,920
THE OF A STATEMENT AS OPPOSED TO

1502
01:00:57,920 --> 01:01:00,360
A QUESTION BUT MAYBE YOU HAD

1503
01:01:00,360 --> 01:01:00,680
CONVERSATION.

1504
01:01:00,680 --> 01:01:03,480
SEVERAL OF US ARE DEEPLY

1505
01:01:03,480 --> 01:01:05,800
CONCERNED THAT THE ADDITIONAL

1506
01:01:05,800 --> 01:01:07,200
COVID RELIEF PACKAGES HAVE

1507
01:01:07,200 --> 01:01:07,600
STALLED.

1508
01:01:07,600 --> 01:01:08,920
I THINK IT'S JUST IMPORTANT TO

1509
01:01:08,920 --> 01:01:12,840
BE ON THE RECORD TO SAY THAT,

1510
01:01:12,840 --> 01:01:14,760
YOU KNOW, SHOULD UNFORTUNATELY

1511
01:01:14,760 --> 01:01:17,160
THE COUNTRY HAVE MORE SURGES, WE

1512
01:01:17,160 --> 01:01:19,800
HAVE TO UNDERSTAND THAT A SURGE

1513
01:01:19,800 --> 01:01:22,760
OF COVID WILL HINDER OUR ABILITY

1514
01:01:22,760 --> 01:01:25,320
IN THE CANCER COMMUNITY TO

1515
01:01:25,320 --> 01:01:26,800
ENROLL PATIENTS TO TRIALS, TO

1516
01:01:26,800 --> 01:01:27,760
CONTINUE THE DISCOVERY WORK

1517
01:01:27,760 --> 01:01:28,640
THAT'S SO ESSENTIAL.

1518
01:01:28,640 --> 01:01:30,920
I HAVEN'T REALLY SEEN THAT

1519
01:01:30,920 --> 01:01:32,400
CONVERSATION AT THE NATIONAL

1520
01:01:32,400 --> 01:01:32,600
LEVEL.

1521
01:01:32,600 --> 01:01:35,680
I DON'T KNOW IF CONGRESS IS

1522
01:01:35,680 --> 01:01:38,280
AWARE OF THOSE CONNECTIONS, THAT

1523
01:01:38,280 --> 01:01:40,160
COVID MAKES CANCER CARE AND

1524
01:01:40,160 --> 01:01:42,680
CLINICAL TRIALS EXCEEDINGLY

1525
01:01:42,680 --> 01:01:43,560
DIFFICULT.

1526
01:01:43,560 --> 01:01:45,400
AND WE HAVE DOCUMENTED EXCESS

1527
01:01:45,400 --> 01:01:46,640
MORTALITY DURING THE COVID

1528
01:01:46,640 --> 01:01:47,960
PERIOD FOR PATIENTS WITH CANCER,

1529
01:01:47,960 --> 01:01:49,560
WHETHER THEY HAD COVID OR NOT

1530
01:01:49,560 --> 01:01:51,400
SIMPLY BECAUSE THEY CAN'T GET

1531
01:01:51,400 --> 01:01:51,600
CARE.

1532
01:01:51,600 --> 01:01:53,600
I GUESS THAT'S MY STATEMENT.

1533
01:01:53,600 --> 01:01:57,200
THE QUESTION FOR YOU IS, HAS

1534
01:01:57,200 --> 01:01:59,680
THAT CONNECTION BETWEEN COVID

1535
01:01:59,680 --> 01:02:02,640
RELIEF FUNDS AND ITS IMPACT ON

1536
01:02:02,640 --> 01:02:04,440
EITHER CANCER CARE DELIVERY OR

1537
01:02:04,440 --> 01:02:05,120
CLINICAL TRIAL ENTERPRISE, HAS

1538
01:02:05,120 --> 01:02:06,720
THAT BEEN A CONVERSATION THAT

1539
01:02:06,720 --> 01:02:07,760
YOU'VE HEARD ABOUT?

1540
01:02:07,760 --> 01:02:09,280
>> YOU KNOW, IT'S A REALLY

1541
01:02:09,280 --> 01:02:10,040
INTERESTING QUESTION.

1542
01:02:10,040 --> 01:02:12,160
I'M NOT SURE IT'S HAPPENED IN

1543
01:02:12,160 --> 01:02:15,440
QUITE THAT WAY.

1544
01:02:15,440 --> 01:02:18,080
WE HAVE RECEIVED SINCE THE

1545
01:02:18,080 --> 01:02:22,200
BEGINNING WHEN NCI RECEIVED A

1546
01:02:22,200 --> 01:02:25,560
$306 MILLION PIECE OF THE COVID

1547
01:02:25,560 --> 01:02:28,000
FUNDING AS PART OF AN NIH

1548
01:02:28,000 --> 01:02:29,440
PACKAGE, THERE'S BEEN INTEREST

1549
01:02:29,440 --> 01:02:31,200
IN HOW COVID AFFECTED THE QUICK

1550
01:02:31,200 --> 01:02:32,040
ADJUSTMENTS MADE TO CLINICAL

1551
01:02:32,040 --> 01:02:33,840
TRIALS, SO WE WERE ABLE TO

1552
01:02:33,840 --> 01:02:35,160
CONTINUE SOME REALLY IMPORTANT

1553
01:02:35,160 --> 01:02:39,000
PROGRAMS AND ACCESS FOR

1554
01:02:39,000 --> 01:02:39,400
PATIENTS.

1555
01:02:39,400 --> 01:02:40,800
NCI'S WORKED WITH SEROLOGY AND

1556
01:02:40,800 --> 01:02:41,600
EXCESS MORTALITY.

1557
01:02:41,600 --> 01:02:42,880
BUT I DON'T THINK IT'S BEEN

1558
01:02:42,880 --> 01:02:44,840
LOOKED AT IN SORT OF THAT

1559
01:02:44,840 --> 01:02:46,760
HOLISTIC WAY BECAUSE THAT MUST

1560
01:02:46,760 --> 01:02:49,720
ALSO BE TRUE FOR OTHER DISEASE

1561
01:02:49,720 --> 01:02:50,280
AREAS AS WELL.

1562
01:02:50,280 --> 01:02:52,840
AND, YOU KNOW, I THINK THAT'S

1563
01:02:52,840 --> 01:02:55,160
ACTUALLY A REALLY IMPORTANT

1564
01:02:55,160 --> 01:02:55,840
POINT.

1565
01:02:55,840 --> 01:02:57,240
AND I DON'T KNOW, I THINK WE'LL

1566
01:02:57,240 --> 01:02:59,120
SEE THE RUBBER WILL MEET THE

1567
01:02:59,120 --> 01:03:00,200
ROAD AFTER MIDTERMS IN TERMS OF

1568
01:03:00,200 --> 01:03:02,400
WHO IS WILLING TO GO TO BAT AND

1569
01:03:02,400 --> 01:03:04,760
SAY, LOOK, YOU MAY BE TIRED OF

1570
01:03:04,760 --> 01:03:06,200
TALKING ABOUT IT BUT COVID IS

1571
01:03:06,200 --> 01:03:07,120
NOT TIRED OF BEING HERE.

1572
01:03:07,120 --> 01:03:12,840
WE NEED TO ADDRESS IT AND BE

1573
01:03:12,840 --> 01:03:13,080
PREPARED.

1574
01:03:13,080 --> 01:03:20,120
AND PERHAPS SOME CONCERN ABOUT

1575
01:03:20,120 --> 01:03:22,480
MONKEYPOX WILL STIR THE FUNDING

1576
01:03:22,480 --> 01:03:23,920
BUT HELPFUL TO COME FROM PATIENT

1577
01:03:23,920 --> 01:03:29,160
GROUPS AND RESEARCHERS AS WELL.

1578
01:03:29,160 --> 01:03:31,360
>> GREAT COMMENT, CHRIS.

1579
01:03:31,360 --> 01:03:34,200
THANKS FOR THAT PERSPECTIVE,

1580
01:03:34,200 --> 01:03:34,360
M.K.

1581
01:03:34,360 --> 01:03:37,120
I THINK IT'S TIME TO MOVE ON TO

1582
01:03:37,120 --> 01:03:39,680
THE NEXT AGENDA ITEM WHICH WILL

1583
01:03:39,680 --> 01:03:41,960
BE A SCIENTIFIC PRESENTATION

1584
01:03:41,960 --> 01:03:49,280
FROM THE INTRAMURAL PROGRAM ON 

1585
01:03:49,280 --> 01:03:53,040
HPV EPIDEMIOLOGY AND PREDICTING

1586
01:03:53,040 --> 01:03:54,680
COST EFFECTIVE CERVICAL

1587
01:03:54,680 --> 01:03:56,080
SCREENING FROM DR. SHIFFMAN,

1588
01:03:56,080 --> 01:03:57,640
DIVISION OF CANCER EPIDEMIOLOGY

1589
01:03:57,640 --> 01:04:06,360
AND CANCER GENETICS. 

1590
01:04:06,360 --> 01:04:06,920
MARK?

1591
01:04:06,920 --> 01:04:08,320
>> HELLO.

1592
01:04:08,320 --> 01:04:14,840
>> PLEASE PUT UP MARK'S
SLIDES.

1593
01:04:14,840 --> 01:04:18,680
>> I'VE BEEN ASKED TO TALK
ABOUT

1594
01:04:18,680 --> 01:04:21,680
HOW EPIDEMIOLOGY IS PREDICTING

1595
01:04:21,680 --> 01:04:23,280
COST EFFECTIVE CERVICAL

1596
01:04:23,280 --> 01:04:26,120
SCREENING SOLUTIONS, JOINED BY

1597
01:04:26,120 --> 01:04:30,800
NICOLE CAMPOS FROM HARVARD TO

1598
01:04:30,800 --> 01:04:33,760
WORK ON THIS QUESTION.

1599
01:04:33,760 --> 01:04:36,200
WE HAVE NO CONFLICTS INTEREST.

1600
01:04:36,200 --> 01:04:38,400
TO AVOID CONFLICTS OF INTEREST

1601
01:04:38,400 --> 01:04:47,040
OVER MY CAREER WE PAY FOR 

1602
01:04:47,040 --> 01:04:47,640
COMMERCIAL PRODUCTS, PUBLISH

1603
01:04:47,640 --> 01:04:48,320
INDEPENDENTLY.

1604
01:04:48,320 --> 01:04:49,840
THIS IS A PERSONAL PERSPECTIVE

1605
01:04:49,840 --> 01:04:52,320
I'D LIKE TO POINT OUT.

1606
01:04:52,320 --> 01:04:57,960
WE WANT TO SHOW HOW 

1607
01:04:57,960 --> 01:04:58,720
EPIDEMIOLOGIC UNDERSTANDING OF

1608
01:04:58,720 --> 01:05:02,720
HPV AND  CARCINOGENESIS CAN

1609
01:05:02,720 --> 01:05:03,520
GUIDE STRATEGIES.

1610
01:05:03,520 --> 01:05:05,280
OF ALL THE MAJOR CANCERS WE KNOW

1611
01:05:05,280 --> 01:05:07,640
MORE I THINK ABOUT CERVICAL

1612
01:05:07,640 --> 01:05:09,960
CANCER AND HPV THAN ANY OF THE

1613
01:05:09,960 --> 01:05:10,760
OTHERS.

1614
01:05:10,760 --> 01:05:13,200
WE HAVE A UNIQUE OPPORTUNITY TO

1615
01:05:13,200 --> 01:05:15,640
KNOW THE CAUSAL AGENT AND HOW TO

1616
01:05:15,640 --> 01:05:17,320
STOP IT.

1617
01:05:17,320 --> 01:05:20,040
AND THEN TO FIGURE OUT HOW TO

1618
01:05:20,040 --> 01:05:21,240
GET IT DONE.

1619
01:05:21,240 --> 01:05:23,320
MY FOCUS HAS BEEN ON

1620
01:05:23,320 --> 01:05:24,640
LOW-RESOURCE SETTINGS SINCE THE

1621
01:05:24,640 --> 01:05:26,840
START OF MY CAREER WHEN I LIVED

1622
01:05:26,840 --> 01:05:29,760
IN AFRICA AND WENT TO MED SCHOOL

1623
01:05:29,760 --> 01:05:34,160
AND THEN CAME TO NCI TO WORK ON

1624
01:05:34,160 --> 01:05:36,440
WHAT EVENTUALLY WAS A WHOLE

1625
01:05:36,440 --> 01:05:38,080
CAREER IN CERVICAL CANCER.

1626
01:05:38,080 --> 01:05:38,920
THIS SHORT PRESENTATION SHOWS

1627
01:05:38,920 --> 01:05:40,440
KEY PRINCIPLES OF WHAT WE'VE

1628
01:05:40,440 --> 01:05:41,600
LEARNED AND GIVES EXAMPLE OF

1629
01:05:41,600 --> 01:05:44,160
WHAT WE'VE COME UP WITH.

1630
01:05:44,160 --> 01:05:47,000
WITH THE MOONSHOT BEING THE MAIN

1631
01:05:47,000 --> 01:05:49,800
FUNDING, I'D LIKE TO POINT OUT,

1632
01:05:49,800 --> 01:05:51,840
SOME GREAT GRATITUDE AND OFFICE

1633
01:05:51,840 --> 01:05:55,840
OF AIDS RESEARCH AND INTRAMURAL

1634
01:05:55,840 --> 01:05:56,880
RESEARCH.

1635
01:05:56,880 --> 01:05:57,640
THE DISPARITIES IN CERVICAL

1636
01:05:57,640 --> 01:06:00,040
CANCER HAVE BEEN GREAT AND JUST

1637
01:06:00,040 --> 01:06:00,360
GETTING WORSE.

1638
01:06:00,360 --> 01:06:02,760
WE'RE DOING SO WELL BECAUSE OF

1639
01:06:02,760 --> 01:06:05,680
OUR NEW KNOWLEDGE OF HPV.

1640
01:06:05,680 --> 01:06:06,720
IN CERTAIN PLACES.

1641
01:06:06,720 --> 01:06:09,120
BUT FAILING TO REACH OTHER

1642
01:06:09,120 --> 01:06:13,920
PLACES SO THAT IT'S EXACERBATING

1643
01:06:13,920 --> 01:06:15,480
THE RELATIVE DISPARITY AND

1644
01:06:15,480 --> 01:06:17,760
BECOMING A DISEASE OF HEALTH

1645
01:06:17,760 --> 01:06:20,240
DISPARITY, BOTH NATIONALLY AND

1646
01:06:20,240 --> 01:06:20,600
INTERNATIONALLY.

1647
01:06:20,600 --> 01:06:22,640
PRACTICE LAGS BEHIND SCIENCE BY

1648
01:06:22,640 --> 01:06:24,800
DECADES IN CERTAIN PLACES.

1649
01:06:24,800 --> 01:06:26,880
IN CONTEXT OF W.H.O. CALL FOR

1650
01:06:26,880 --> 01:06:28,640
ACTION FOR ELIMINATION, WE HAVE

1651
01:06:28,640 --> 01:06:32,200
TO REALIZE THAT THERE'S A VERY

1652
01:06:32,200 --> 01:06:33,880
UNEVEN PATH TO ELIMINATION

1653
01:06:33,880 --> 01:06:35,280
DEPENDING WHERE YOU'RE AT.

1654
01:06:35,280 --> 01:06:37,480
THIS IS A REALLY NEW AND

1655
01:06:37,480 --> 01:06:38,440
FASCINATING GRAPH.

1656
01:06:38,440 --> 01:06:40,480
IT'S WORTH SPENDING A MINUTE ON.

1657
01:06:40,480 --> 01:06:42,520
IT'S IN MILLIONS OF PEOPLE.

1658
01:06:42,520 --> 01:06:45,000
IT'S SHOWING WHERE PEOPLE HAVE

1659
01:06:45,000 --> 01:06:47,760
NEVER BEEN SCREENED.

1660
01:06:47,760 --> 01:06:50,080
NOW, IF YOU IGNORE VACCINE AGES

1661
01:06:50,080 --> 01:06:52,000
AND JUST SAY SOMEBODY OVER 20

1662
01:06:52,000 --> 01:06:54,800
AND WHETHER THEY ARE IN A LOW

1663
01:06:54,800 --> 01:06:56,200
INCOME, LOWER MIDDLE, UPPER

1664
01:06:56,200 --> 01:07:00,120
MIDDLE, OR HIGH INCOME SETTING,

1665
01:07:00,120 --> 01:07:02,120
THE SCREENING KEY AGES WE'LL

1666
01:07:02,120 --> 01:07:03,920
TALK ABOUT IS BETWEEN 30 AND 49

1667
01:07:03,920 --> 01:07:05,080
OR 30 AND 45.

1668
01:07:05,080 --> 01:07:07,160
THOSE ARE THE BEST SCREENING

1669
01:07:07,160 --> 01:07:07,480
YEARS.

1670
01:07:07,480 --> 01:07:10,480
WHERE YOU CAN CATCH PRE-CANCER

1671
01:07:10,480 --> 01:07:11,720
AND PREVENT CANCER.

1672
01:07:11,720 --> 01:07:13,320
AND BECAUSE OF THAT, YOU WONDER

1673
01:07:13,320 --> 01:07:15,200
WHERE ARE THE MILLIONS OF PEOPLE

1674
01:07:15,200 --> 01:07:17,280
WHO ARE TOO OLD TO BE

1675
01:07:17,280 --> 01:07:20,200
VACCINATED, AND ARE GOING TO BE

1676
01:07:20,200 --> 01:07:22,560
AT RISK BECAUSE OF LACK OF ANY

1677
01:07:22,560 --> 01:07:24,120
SCREENING EVER, AND WHERE ARE

1678
01:07:24,120 --> 01:07:26,080
THE DEATHS GOING TO COME FROM?

1679
01:07:26,080 --> 01:07:29,000
YOU SEE IN TERMS OF SHEER

1680
01:07:29,000 --> 01:07:30,480
MILLIONS AND MILLIONS, MAINLY

1681
01:07:30,480 --> 01:07:33,560
THEY ARE IN LOWER, MIDDLE, SOME

1682
01:07:33,560 --> 01:07:34,760
OF THE UPPER MIDDLE, MEANING

1683
01:07:34,760 --> 01:07:36,960
THERE ARE SOME RESOURCES TO BE

1684
01:07:36,960 --> 01:07:37,200
HAD.

1685
01:07:37,200 --> 01:07:40,320
THE QUESTION IS, WILL THEY BE

1686
01:07:40,320 --> 01:07:42,400
ALLOCATED TO WHAT'S INCREASINGLY

1687
01:07:42,400 --> 01:07:46,000
EFFECTIVE VACCINE AND SCREENING

1688
01:07:46,000 --> 01:07:46,280
PROGRAMS.

1689
01:07:46,280 --> 01:07:48,160
MOST PEOPLE I THINK DON'T HAVE A

1690
01:07:48,160 --> 01:07:50,160
CLUE AS TO HOW COST

1691
01:07:50,160 --> 01:07:51,480
EFFECTIVENESS ANALYSES ARE

1692
01:07:51,480 --> 01:07:53,560
REALLY PERFORMED.

1693
01:07:53,560 --> 01:07:55,480
I DIDN'T.

1694
01:07:55,480 --> 01:07:57,680
AND I KNOW IT WAS COST VERSUS

1695
01:07:57,680 --> 01:08:00,520
BENEFIT BUT IT TURNS OUT THAT

1696
01:08:00,520 --> 01:08:02,120
THE FIRST THING AND ESSENTIAL

1697
01:08:02,120 --> 01:08:04,600
THING YOU DO IS TO DEVELOP A

1698
01:08:04,600 --> 01:08:05,560
NATURAL HISTORY MODEL.

1699
01:08:05,560 --> 01:08:07,160
YOU HAVE TO DETERMINE WHAT THE

1700
01:08:07,160 --> 01:08:09,520
HEALTH STATES ARE THAT LEAD TO

1701
01:08:09,520 --> 01:08:12,440
THAT CANCER OR OTHER DISEASE.

1702
01:08:12,440 --> 01:08:17,280
, DEFINE THE TRANSITIONS, DEVINE

1703
01:08:17,280 --> 01:08:20,520
VARIABLES AND MODIFY, ESTIMATE

1704
01:08:20,520 --> 01:08:21,320
TRANSITION RISK, CALIBRATE

1705
01:08:21,320 --> 01:08:21,800
ANYTHING YOU DON'T KNOW.

1706
01:08:21,800 --> 01:08:23,520
IF YOU DON'T KNOW A TRANSITION,

1707
01:08:23,520 --> 01:08:25,960
YOU NEED TO ESTIMATE IT.

1708
01:08:25,960 --> 01:08:27,560
YOU VALIDATE THE MODEL AGAINST

1709
01:08:27,560 --> 01:08:30,240
KNOWN DATA AND THEN YOU TAKE

1710
01:08:30,240 --> 01:08:31,440
WHATEVER YOUR PREVENTION

1711
01:08:31,440 --> 01:08:34,000
STRATEGY IS, ESTIMATE ITS

1712
01:08:34,000 --> 01:08:44,520
EFFICACY, APPLY TO A COHORT, 

1713
01:08:46,480 --> 01:08:48,080
THERE'S MANY WAYS TO CALIBRATION

1714
01:08:48,080 --> 01:08:50,360
AND OFTEN UNCERTAIN KNOWLEDGE OF

1715
01:08:50,360 --> 01:08:52,480
A NATURAL HISTORY.

1716
01:08:52,480 --> 01:08:58,040
A LOT OF TIMES, PEOPLE CONSIDER

1717
01:08:58,040 --> 01:09:00,240
HEALTH DECISION ANALYSES TO BE

1718
01:09:00,240 --> 01:09:02,960
NOT AS IMPORTANT RESEARCH

1719
01:09:02,960 --> 01:09:04,160
FINDINGS AS DIRECT OBSERVATION.

1720
01:09:04,160 --> 01:09:06,680
WHAT WE'VE DONE IS WIDENING THE

1721
01:09:06,680 --> 01:09:13,160
SCOPE OVER THE YEARS IN THE NCI.

1722
01:09:13,160 --> 01:09:14,360
WE HAVE DONE INCREASINGLY

1723
01:09:14,360 --> 01:09:17,360
APPLICABLE THINGS ABOUT COST

1724
01:09:17,360 --> 01:09:18,240
EFFECTIVENESS.

1725
01:09:18,240 --> 01:09:19,880
FIRST WE STARTED WITH ETIOLOGY

1726
01:09:19,880 --> 01:09:22,560
AND PATHOGENESIS, WHEN WE DIDN'T

1727
01:09:22,560 --> 01:09:24,440
KNOW.

1728
01:09:24,440 --> 01:09:27,280
I STARTED IN 1975, IN THE FIELD,

1729
01:09:27,280 --> 01:09:30,120
AND I'VE BEEN WORKING 40 YEARS

1730
01:09:30,120 --> 01:09:32,240
FOR THE IRP, AND WE STARTED WITH

1731
01:09:32,240 --> 01:09:37,360
ODDS RATIOS LOOKING FOR THE

1732
01:09:37,360 --> 01:09:39,520
CAUSE AND SPENT THAT TIME

1733
01:09:39,520 --> 01:09:42,040
LOOKING FOR THE HPV TYPES THAT

1734
01:09:42,040 --> 01:09:44,440
WERE INVOLVED, THEN WE HAD

1735
01:09:44,440 --> 01:09:45,440
PREVENTION METHODS PERIOD, AND

1736
01:09:45,440 --> 01:09:47,800
NOW WE'RE VERY MUCH IN THE HEART

1737
01:09:47,800 --> 01:09:51,080
OF CLINICAL EPIDEMIOLOGY WHERE

1738
01:09:51,080 --> 01:09:52,760
WE'RE ESTIMATING RISK,

1739
01:09:52,760 --> 01:09:53,280
ARTIFICIAL INTELLIGENCE

1740
01:09:53,280 --> 01:09:54,320
GUIDELINES, PREVENTIVE

1741
01:09:54,320 --> 01:09:55,440
STRATEGIES, AND COST

1742
01:09:55,440 --> 01:09:55,960
EFFECTIVENESS.

1743
01:09:55,960 --> 01:09:58,360
BUT ALL OF THESE CONTINUE ON.

1744
01:09:58,360 --> 01:10:00,520
IT'S JUST WE'VE ADDED THE SCOPE

1745
01:10:00,520 --> 01:10:02,080
AS WE'VE GONE.

1746
01:10:02,080 --> 01:10:04,600
I WANTED TO SAY ONLY THAT THIS

1747
01:10:04,600 --> 01:10:06,480
IS ONE OF THE BEST UNDERSTOOD

1748
01:10:06,480 --> 01:10:08,200
NATURAL HISTORIES OF ANY MAJOR

1749
01:10:08,200 --> 01:10:08,960
CANCER.

1750
01:10:08,960 --> 01:10:10,480
AND IT LOOKS LIKE A CARTOON BUT

1751
01:10:10,480 --> 01:10:11,560
IT'S NOT.

1752
01:10:11,560 --> 01:10:15,200
IT'S ACTUALLY STOOD UP QUITE

1753
01:10:15,200 --> 01:10:15,760
WELL.

1754
01:10:15,760 --> 01:10:21,920
THE USUAL PATTERN IS HEALTHY

1755
01:10:21,920 --> 01:10:24,520
TISSUE, MINOR, SEVERE, DEATH.

1756
01:10:24,520 --> 01:10:26,280
FOR CERVIX 13 TYPES, THEY APPEAR

1757
01:10:26,280 --> 01:10:27,880
AND IF THEY DON'T GO AWAY WHICH

1758
01:10:27,880 --> 01:10:29,880
THEY USUALLY DO IT'S VERY

1759
01:10:29,880 --> 01:10:32,440
DYNAMIC AND COMMON, THERE'S A

1760
01:10:32,440 --> 01:10:34,400
PROGRESSION TO PRE-CANCER,

1761
01:10:34,400 --> 01:10:36,280
USUALLY SQUAMOUS, WHICH OVER

1762
01:10:36,280 --> 01:10:38,640
TIME CAN HAVE A GENETIC

1763
01:10:38,640 --> 01:10:39,920
MUTATION, INVADE AND CAUSE

1764
01:10:39,920 --> 01:10:40,200
DEATH.

1765
01:10:40,200 --> 01:10:42,320
THESE TERMS WHICH DON'T SEEM

1766
01:10:42,320 --> 01:10:44,560
LIKE SCIENTIFIC TERMS GIVEN WHAT

1767
01:10:44,560 --> 01:10:48,440
WE KNOW IS CIN OR OTHER TERMS

1768
01:10:48,440 --> 01:10:50,040
ARE BETTER TERMS BECAUSE THEY

1769
01:10:50,040 --> 01:10:52,720
ARE EXACT AND BASED ON MOLECULAR

1770
01:10:52,720 --> 01:10:56,400
AND OTHER EXACT MEASUREMENTS.

1771
01:10:56,400 --> 01:11:00,440
WE KNOW HPVs EXACTLY, WHERE IN

1772
01:11:00,440 --> 01:11:02,280
THE GENETICS AND PHYLOGENY

1773
01:11:02,280 --> 01:11:05,480
ONCOGENIC ARE, WE KNOW BY TYPE,

1774
01:11:05,480 --> 01:11:07,000
CAN MEASURE RELIABLY AND

1775
01:11:07,000 --> 01:11:09,720
ACCURATELY, AND PAY ATTENTION

1776
01:11:09,720 --> 01:11:13,360
ONLY TO THOSE THAT CAUSE

1777
01:11:13,360 --> 01:11:14,760
CERVICAL CANCER, WE KNOW THEIR

1778
01:11:14,760 --> 01:11:16,400
ORDER OF IMPORTANCE WHEN WE

1779
01:11:16,400 --> 01:11:18,160
STUDY TENS OF THOUSANDS OF

1780
01:11:18,160 --> 01:11:19,480
CERVICAL CANCERS.

1781
01:11:19,480 --> 01:11:23,760
SO WE KNOW TYPE 16 IS THE WORST.

1782
01:11:23,760 --> 01:11:27,200
1845 LESS.

1783
01:11:27,200 --> 01:11:30,120
NEXT THE 16 RELATED, AND OTHERS

1784
01:11:30,120 --> 01:11:32,200
CONSIDERED CARCINOGENIC BUT VERY

1785
01:11:32,200 --> 01:11:32,520
RARELY.

1786
01:11:32,520 --> 01:11:33,920
CANCER SERIES AND COHORTS SAY

1787
01:11:33,920 --> 01:11:35,200
THE SAME THING.

1788
01:11:35,200 --> 01:11:37,040
THERE'S NO COUNTER DATA.

1789
01:11:37,040 --> 01:11:38,480
WE KNOW EXACTLY WHICH TYPES AND

1790
01:11:38,480 --> 01:11:42,360
WHICH ONES ARE THE MOST

1791
01:11:42,360 --> 01:11:42,760
IMPORTANT.

1792
01:11:42,760 --> 01:11:44,320
ACCURACY IS REALLY IMPORTANT IN

1793
01:11:44,320 --> 01:11:46,760
CAUSAL CHANGE AND SO THAT LED

1794
01:11:46,760 --> 01:11:48,440
NATURALLY TO PREVENTIVE METHODS.

1795
01:11:48,440 --> 01:11:50,840
THOSE ARE MAINLY COHORT STUDIES

1796
01:11:50,840 --> 01:11:53,440
AND TRIALS WE DID IN THE '90s

1797
01:11:53,440 --> 01:11:57,320
AND 2000s, STILL ONGOING.

1798
01:11:57,320 --> 01:11:58,720
THE EPIDEMIOLOGISTS PIVOTED, AND

1799
01:11:58,720 --> 01:12:02,080
WE WERE WORKING WITH

1800
01:12:02,080 --> 01:12:03,080
IMMUNOLOGISTS, VIROLOGISTS, DNA

1801
01:12:03,080 --> 01:12:04,400
DIAGNOSTIC FOLKS, AND THROUGH

1802
01:12:04,400 --> 01:12:07,080
THOSE WE GOT VERY GOOD IDEAS OF

1803
01:12:07,080 --> 01:12:09,520
WHAT THE RELATIVE RISKS WERE AND

1804
01:12:09,520 --> 01:12:10,320
REDUCTIONS IN VACCINE EFFICACY

1805
01:12:10,320 --> 01:12:13,760
SO WE KNOW WHAT THE

1806
01:12:13,760 --> 01:12:15,120
INTERVENTIONS CAN DO, SCREENING,

1807
01:12:15,120 --> 01:12:18,720
AND VACCINE.

1808
01:12:18,720 --> 01:12:22,840
NOW WE'RE ON TO VACCINATION

1809
01:12:22,840 --> 01:12:26,680
BREAKING THAT FIRST EXPOSURE AND

1810
01:12:26,680 --> 01:12:32,680
WE HAVE ALSO SCREENING WHICH IS

1811
01:12:32,680 --> 01:12:33,280
FINDING PRE-CANCER BEFORE

1812
01:12:33,280 --> 01:12:35,440
CANCER, THE GOAL IS TO FIND

1813
01:12:35,440 --> 01:12:36,880
PRE-CANCER AND WE HELPED

1814
01:12:36,880 --> 01:12:40,080
VALIDATE MANY METHODS.

1815
01:12:40,080 --> 01:12:43,080
RIGHT NOW, WE'RE GOING TO

1816
01:12:43,080 --> 01:12:44,840
STRATEGIES BECAUSE BY 2005 WE

1817
01:12:44,840 --> 01:12:46,640
KNEW ALL THIS STUFF ABOVE.

1818
01:12:46,640 --> 01:12:49,120
AND IT'S STILL ALL THESE YEARS

1819
01:12:49,120 --> 01:12:50,120
LATER, WE'RE LOOKING TO HOW TO

1820
01:12:50,120 --> 01:12:52,400
GET IT TO THE PEOPLE WHO NEED IT

1821
01:12:52,400 --> 01:12:52,960
MOST.

1822
01:12:52,960 --> 01:12:55,880
THERE'S BEEN A STAGNATION OF THE

1823
01:12:55,880 --> 01:12:59,280
DECLINE IN THE UNITED STATES.

1824
01:12:59,280 --> 01:13:01,400
THERE'S A CONTINUED INCREASE IN

1825
01:13:01,400 --> 01:13:03,320
NUMBERS OF DEATHS, PLACES AROUND

1826
01:13:03,320 --> 01:13:05,840
THE WORLD, AGE THAT ARE HIGH

1827
01:13:05,840 --> 01:13:06,040
RISK.

1828
01:13:06,040 --> 01:13:07,400
WE'RE NOW TALKING VERY MUCH

1829
01:13:07,400 --> 01:13:10,080
ABOUT WHAT ARE THE WAYS TO MAKE

1830
01:13:10,080 --> 01:13:12,120
THESE INTERVENTIONS THAT ARE SO

1831
01:13:12,120 --> 01:13:15,200
ACCURATE SIMPLE ENOUGH AND COST

1832
01:13:15,200 --> 01:13:16,600
EFFECTIVE THAT THEY CAN COMPETE

1833
01:13:16,600 --> 01:13:18,480
FOR ATTENTION IN A WORLD THAT

1834
01:13:18,480 --> 01:13:20,320
HAS SO MANY DIFFERENT

1835
01:13:20,320 --> 01:13:20,840
PRIORITIES.

1836
01:13:20,840 --> 01:13:23,240
THE EMPHASIS IS ALWAYS ON

1837
01:13:23,240 --> 01:13:23,680
ABSOLUTE RISK.

1838
01:13:23,680 --> 01:13:25,640
SO, IF YOU THINK ABOUT THE

1839
01:13:25,640 --> 01:13:27,360
BEGINNING, WE JUST DIDN'T KNOW

1840
01:13:27,360 --> 01:13:28,600
PEOPLE GOT CERVICAL CANCER,

1841
01:13:28,600 --> 01:13:29,440
DIDN'T KNOW WHY.

1842
01:13:29,440 --> 01:13:31,880
AND WE'VE BEEN ABLE LIKE PLAYING

1843
01:13:31,880 --> 01:13:35,040
THE GAME OF TWENTY QUESTIONS TO

1844
01:13:35,040 --> 01:13:36,240
DERIVE QUESTIONS THAT ARE VERY

1845
01:13:36,240 --> 01:13:38,800
EXACT TO GET TO WHO IS AT RISK.

1846
01:13:38,800 --> 01:13:41,440
WE CAN DO IT QUITE WELL.

1847
01:13:41,440 --> 01:13:42,840
TAKE A SCREENING POPULATION.

1848
01:13:42,840 --> 01:13:44,920
AND THEN YOU JUST ASK PEOPLE,

1849
01:13:44,920 --> 01:13:46,320
ARE YOU HPV POSITIVE TODAY OR

1850
01:13:46,320 --> 01:13:46,680
NOT?

1851
01:13:46,680 --> 01:13:50,360
THAT'S ONE OF THE GOOD TESTS.

1852
01:13:50,360 --> 01:13:52,280
IF YOU'RE NEGATIVE, REASSURED.

1853
01:13:52,280 --> 01:13:52,920
INCREDIBLY PREDICTIVE.

1854
01:13:52,920 --> 01:13:56,400
IF YOU HAVE TWO NEGATIVES, VERY,

1855
01:13:56,400 --> 01:13:57,320
VERY REASSURING.

1856
01:13:57,320 --> 01:13:58,560
HPV POSITIVE YOU'RE ALERTED BUT

1857
01:13:58,560 --> 01:14:00,880
STILL DON'T KNOW WHO HAS

1858
01:14:00,880 --> 01:14:02,040
PRE-CANCER BECAUSE INFECTION IS

1859
01:14:02,040 --> 01:14:03,760
MUCH MORE COMMON AND OFTEN GOES

1860
01:14:03,760 --> 01:14:04,400
AWAY.

1861
01:14:04,400 --> 01:14:06,560
THEN IF YOU HAVE THAT, YOU NEED

1862
01:14:06,560 --> 01:14:08,080
A TRIAGE TEST, WHICH IF PERFECT

1863
01:14:08,080 --> 01:14:11,680
WOULD FIND ONLY THE PRE-CANCERS,

1864
01:14:11,680 --> 01:14:13,640
AMONG HPV POSITIVES, TURNS OUT

1865
01:14:13,640 --> 01:14:16,000
USUALLY YOU CAN HAVE THE NUMBER

1866
01:14:16,000 --> 01:14:17,760
AND GET CLOSER TO KNOWING

1867
01:14:17,760 --> 01:14:19,360
EXACTLY THAT THE PEOPLE YOU NEED

1868
01:14:19,360 --> 01:14:20,520
TO BE TREATING ARE WITHIN THAT

1869
01:14:20,520 --> 01:14:23,680
GROUP AND YOU DON'T WANT TO MISS

1870
01:14:23,680 --> 01:14:26,560
THEM BECAUSE THEY MOTIVATE THE

1871
01:14:26,560 --> 01:14:28,680
ENTIRE EXERCISE.

1872
01:14:28,680 --> 01:14:30,520
ACCURACY EQUALS EFFICACY.

1873
01:14:30,520 --> 01:14:31,760
OLDER TECHNOLOGIES NEED

1874
01:14:31,760 --> 01:14:33,360
REPETITION TO OVERCOME ERROR.

1875
01:14:33,360 --> 01:14:34,640
BUT HIGHLY ACCURATE TEST

1876
01:14:34,640 --> 01:14:36,640
PERFORMED LESS OFTEN IS

1877
01:14:36,640 --> 01:14:36,960
PREFERABLE.

1878
01:14:36,960 --> 01:14:42,000
WE DON'T WANT TO DO ACCURATE

1879
01:14:42,000 --> 01:14:43,800
TESTS TOO OFTEN, THE PRINCIPLE

1880
01:14:43,800 --> 01:14:46,040
IS TRUE IN HIGHER RESOURCE

1881
01:14:46,040 --> 01:14:47,600
SETTINGS, IN LOWER FOR

1882
01:14:47,600 --> 01:14:48,560
AFFORDABILITY AND

1883
01:14:48,560 --> 01:14:48,920
SUSTAINABILITY.

1884
01:14:48,920 --> 01:14:50,760
YOU ONLY NEED A COUPLE REALLY

1885
01:14:50,760 --> 01:14:52,600
GOOD SCREENINGS IN A LIFETIME TO

1886
01:14:52,600 --> 01:14:55,320
GREATLY REDUCE RISK.

1887
01:14:55,320 --> 01:14:59,600
AND THE OLD TERMS SO WHAT I DID

1888
01:14:59,600 --> 01:15:01,480
IN MED SCHOOL ARE ANTIQUATED,

1889
01:15:01,480 --> 01:15:03,120
STILL USED ALL THE TIME, USEFUL

1890
01:15:03,120 --> 01:15:06,600
AS A WAY OF COMMUNICATING BUT

1891
01:15:06,600 --> 01:15:08,240
PROXIES FOR THE REAL MOLECULAR

1892
01:15:08,240 --> 01:15:12,000
PROCESSES WE UNDERSTAND AT THE

1893
01:15:12,000 --> 01:15:13,960
HEART OF THE CARCINOGENESIS.

1894
01:15:13,960 --> 01:15:15,400
SIMILARLY ANYBODY WHO THINKS

1895
01:15:15,400 --> 01:15:18,600
THAT YOU CAN LOOK AT A  CERVIX

1896
01:15:18,600 --> 01:15:20,000
AND TELL WHAT IT IS, IT'S HARD

1897
01:15:20,000 --> 01:15:22,240
TO KNOW THE DIFFERENCE BETWEEN

1898
01:15:22,240 --> 01:15:25,280
INFECTION, WHICH IS HERE, AND

1899
01:15:25,280 --> 01:15:25,800
PRE-CANCER.

1900
01:15:25,800 --> 01:15:27,800
SO, WHAT WE'VE DONE IN THE

1901
01:15:27,800 --> 01:15:31,480
MOONSHOT IS TO TRY TO ACCELERATE

1902
01:15:31,480 --> 01:15:37,360
THE TAKING UP OF HPV-BASED

1903
01:15:37,360 --> 01:15:40,640
THERAPIES, AND BASICALLY

1904
01:15:40,640 --> 01:15:42,720
THERAPIES PREVENTIVE THERAPIES,

1905
01:15:42,720 --> 01:15:44,600
LIKE PAVE, HUMAN PAPILLOMAVIRUS

1906
01:15:44,600 --> 01:15:46,440
AND AUTOMATED VISUAL EVALUATION.

1907
01:15:46,440 --> 01:15:48,600
I'M GOING TO USE THIS AS JUST AN

1908
01:15:48,600 --> 01:15:48,800
EXAMPLE.

1909
01:15:48,800 --> 01:15:52,160
THIS IS WHO WE ARE, RIGHT NOW,

1910
01:15:52,160 --> 01:15:54,200
THERE'S LOTS OF US.

1911
01:15:54,200 --> 01:15:57,440
THIS IS MOONSHOT-SUPPORTED

1912
01:15:57,440 --> 01:15:58,680
INITIATIVE, PEOPLE VOLUNTEERED

1913
01:15:58,680 --> 01:16:00,440
AND THEY GOES AWAY.

1914
01:16:00,440 --> 01:16:02,280
BASICALLY WE'RE DOING IT IN THE

1915
01:16:02,280 --> 01:16:05,320
UNITED STATES AND WE HAVE A

1916
01:16:05,320 --> 01:16:09,640
MISSISSIPPI GROUP THAT MEGAN

1917
01:16:09,640 --> 01:16:11,680
CLARK IS RUNNING AND ALL THESE

1918
01:16:11,680 --> 01:16:12,920
DIFFERENT COUNTRIES.

1919
01:16:12,920 --> 01:16:15,520
AFTER A PANDEMIC DELAY WE'RE UP

1920
01:16:15,520 --> 01:16:18,560
TO GETTING READY TO START THE

1921
01:16:18,560 --> 01:16:21,200
SCREENING, A VALIDATION OF THIS

1922
01:16:21,200 --> 01:16:22,200
COST EFFECTIVE DESIGNED

1923
01:16:22,200 --> 01:16:22,440
STRATEGY.

1924
01:16:22,440 --> 01:16:23,400
SO WHAT WE WANT TO DO IS THE

1925
01:16:23,400 --> 01:16:24,920
RIGHT THING FOR THE GREATEST

1926
01:16:24,920 --> 01:16:25,560
NUMBER OF WOMEN.

1927
01:16:25,560 --> 01:16:26,880
AND HOW DO WE DO THAT?

1928
01:16:26,880 --> 01:16:29,040
WE DO IT THROUGH ACCURACY,

1929
01:16:29,040 --> 01:16:30,840
PUTTING THEM ON THEIR RIGHT

1930
01:16:30,840 --> 01:16:32,520
PLACE IN THE CAUSAL DIAGRAM.

1931
01:16:32,520 --> 01:16:34,880
IN OTHER WORDS, AS YOU GET

1932
01:16:34,880 --> 01:16:35,880
INCREASING RISK TOWARDS CERVICAL

1933
01:16:35,880 --> 01:16:38,040
CANCER, YOU DO MORE FOR PEOPLE.

1934
01:16:38,040 --> 01:16:40,120
AND IT'S EQUAL MANAGEMENT OF

1935
01:16:40,120 --> 01:16:40,640
EQUAL RISK.

1936
01:16:40,640 --> 01:16:42,880
THE FIRST THING YOU DO IS GO

1937
01:16:42,880 --> 01:16:44,000
WHERE THERE'S A DISEASE.

1938
01:16:44,000 --> 01:16:45,760
IF YOU'RE A PLACE LIKE BRAZIL,

1939
01:16:45,760 --> 01:16:46,960
YOU KNOW WHERE THERE'S BEEN

1940
01:16:46,960 --> 01:16:49,320
CANCER IN THE LAST FIVE YEARS.

1941
01:16:49,320 --> 01:16:51,560
GO TO THOSE PLACES.

1942
01:16:51,560 --> 01:16:52,840
DON'T GO TO PEOPLE SCREENED A

1943
01:16:52,840 --> 01:16:53,000
LOT.

1944
01:16:53,000 --> 01:16:54,600
GO WHERE THEY HAVEN'T BEEN.

1945
01:16:54,600 --> 01:16:56,440
IF YOU CAN DO THAT, YOU CAN THEN

1946
01:16:56,440 --> 01:17:00,640
FIND WHO IS AT RISK.

1947
01:17:00,640 --> 01:17:02,840
THROUGH A SELF-SWAB TECHNIQUE

1948
01:17:02,840 --> 01:17:05,800
YOU CAN SELF-SAMPLE SOMEBODY,

1949
01:17:05,800 --> 01:17:07,360
THEY SELF-SAMPLE THEMSELVES, THE

1950
01:17:07,360 --> 01:17:08,760
IMPORTANT POINT, THEY

1951
01:17:08,760 --> 01:17:09,800
SELF-SAMPLE.

1952
01:17:09,800 --> 01:17:12,840
WOMEN HELPING WOMEN.

1953
01:17:12,840 --> 01:17:14,720
AND BASICALLY THAT SELF-SAMPLE

1954
01:17:14,720 --> 01:17:16,280
IS ANALOGOUS, ALMOST THE SAME

1955
01:17:16,280 --> 01:17:18,120
SENSITIVITY OF A CLINICIAN

1956
01:17:18,120 --> 01:17:18,360
SAMPLE.

1957
01:17:18,360 --> 01:17:21,040
IT'S THEN PUT INTO A HIGH-RISK

1958
01:17:21,040 --> 01:17:24,120
HPV TEST WHICH WE WORKED HARD TO

1959
01:17:24,120 --> 01:17:27,920
GET TO THE $5 RANGE AND IT

1960
01:17:27,920 --> 01:17:29,680
REASSURES  EVERYONE NEGATIVE AND

1961
01:17:29,680 --> 01:17:33,760
THEY GO  HOME.

1962
01:17:33,760 --> 01:17:35,360
IF POSITIVE, THEY NEED TRIAGE.

1963
01:17:35,360 --> 01:17:38,160
YOU PUT THEM IN TYPE GROUPS TO

1964
01:17:38,160 --> 01:17:39,320
DICTATE RISK, ADD TO THEIR

1965
01:17:39,320 --> 01:17:39,720
APPEARANCE.

1966
01:17:39,720 --> 01:17:41,000
APPEARANCES ARE VERY HARD FOR

1967
01:17:41,000 --> 01:17:43,080
HUMANS TO TELL APART.

1968
01:17:43,080 --> 01:17:45,160
FORTUNATELY, THEY CAN WITH SOME

1969
01:17:45,160 --> 01:17:50,560
RELIABILITY AT THE EXTREMES BE 

1970
01:17:50,560 --> 01:17:52,560
PUT INTO VERY SUSPICIOUS, INTO

1971
01:17:52,560 --> 01:17:54,800
BAD OR GOOD OR DON'T KNOW, BY

1972
01:17:54,800 --> 01:17:56,720
MACHINE LEARNING, DEEP LEARNING.

1973
01:17:56,720 --> 01:17:58,040
THAT'S CALLED AUTOMATED VISUAL

1974
01:17:58,040 --> 01:18:00,640
EVALUATION WHICH WE'VE BEEN

1975
01:18:00,640 --> 01:18:05,720
WORKING ON FOR SEVERAL YEARS 

1976
01:18:05,720 --> 01:18:05,880
NOW.

1977
01:18:05,880 --> 01:18:10,920
THE COMBINATION OF COMMENT 

1978
01:18:10,920 --> 01:18:11,600
ELEMENT -- COMPLEMENTARY

1979
01:18:11,600 --> 01:18:15,560
BIOMARKERS DO THE BEST JOB,

1980
01:18:15,560 --> 01:18:16,400
AGAINST HISTOPATHOLOGY AND

1981
01:18:16,400 --> 01:18:18,480
VIROLOGY CAN KNOW WHO NEEDS TO

1982
01:18:18,480 --> 01:18:20,600
BE TREATED USING NEW TOOLS,

1983
01:18:20,600 --> 01:18:22,880
THERMAL ABLATION, 20 TO 40

1984
01:18:22,880 --> 01:18:26,520
SECONDS, OR IF NEEDED EXCISIONAL

1985
01:18:26,520 --> 01:18:27,280
TREATMENT OR REFERRAL.

1986
01:18:27,280 --> 01:18:28,600
I'M NOT SAYING THIS IS THE WAY

1987
01:18:28,600 --> 01:18:29,400
TO GO.

1988
01:18:29,400 --> 01:18:31,040
THIS IS PRE-PANDEMIC.

1989
01:18:31,040 --> 01:18:32,760
YOU CAN SCREEN HUNDREDS OF

1990
01:18:32,760 --> 01:18:34,720
PEOPLE IN A CLINIC ROOM PER DAY.

1991
01:18:34,720 --> 01:18:37,200
AND IT'S JUST BECAUSE IT'S

1992
01:18:37,200 --> 01:18:37,520
SELF-SAMPLED.

1993
01:18:37,520 --> 01:18:39,760
AND THERE'S MANY DIFFERENT

1994
01:18:39,760 --> 01:18:40,680
APPLICATIONS OF IT.

1995
01:18:40,680 --> 01:18:43,760
NOW, I WANT TO SAY A WORD ABOUT

1996
01:18:43,760 --> 01:18:44,840
ARTIFICIAL INTELLIGENCE AS THE

1997
01:18:44,840 --> 01:18:46,480
NEXT PART BEFORE I END.

1998
01:18:46,480 --> 01:18:48,840
THIS IS A TREMENDOUS IMAGE

1999
01:18:48,840 --> 01:18:49,600
RECOGNITION APPROACH FOR

2000
01:18:49,600 --> 01:18:50,800
CLINICIANS BECAUSE YOU GOT TO

2001
01:18:50,800 --> 01:18:55,680
LOOK AT THE CERVIX TO TREAT, WHY

2002
01:18:55,680 --> 01:18:59,000
NOT TAKE A PICTURE AND HAVE IT

2003
01:18:59,000 --> 01:18:59,280
ANALYZED.

2004
01:18:59,280 --> 01:19:00,960
DON'T BE TAKEN IF IN IT LOOKS

2005
01:19:00,960 --> 01:19:05,040
GOOD TO TO BE TRUE.

2006
01:19:05,040 --> 01:19:09,480
BE SKEPTICAL OF CLAIMS,

2007
01:19:09,480 --> 01:19:10,960
PERFORMANCE DECLINES FROM THE

2008
01:19:10,960 --> 01:19:12,560
TRAINING SETTING AND WE'VE

2009
01:19:12,560 --> 01:19:14,760
GOTTEN BACK TO GOOD A.I. IMAGE

2010
01:19:14,760 --> 01:19:15,640
RECOGNITION FOR PRE-CANCER.

2011
01:19:15,640 --> 01:19:18,360
DEEP LEARNING IS NOT MAGIC, JUST

2012
01:19:18,360 --> 01:19:20,520
WHAT YOU LABEL THINGS.

2013
01:19:20,520 --> 01:19:23,680
HOW WE'RE DOING IT, WE COMBINE

2014
01:19:23,680 --> 01:19:25,640
USING DEVICES EITHER DEDICATED

2015
01:19:25,640 --> 01:19:28,440
OR NOT, WE HAVE MANY DIFFERENT

2016
01:19:28,440 --> 01:19:28,920
ALGORITHMS.

2017
01:19:28,920 --> 01:19:34,080
AND WE PUT TOGETHER THE RISK 

2018
01:19:34,080 --> 01:19:35,160
ESTIMATES FROM THE HPV

2019
01:19:35,160 --> 01:19:37,120
16 IS THE WORST, THAT VARIABLE

2020
01:19:37,120 --> 01:19:38,600
IS CROSSED AGAINST APPEARANCE

2021
01:19:38,600 --> 01:19:41,920
VARIABLE, YOU GET A RISK

2022
01:19:41,920 --> 01:19:43,880
STRATIFICATION SCORE WHICH CAN

2023
01:19:43,880 --> 01:19:48,600
BE USED BY THE LOCAL NLH OR

2024
01:19:48,600 --> 01:19:52,280
WHATEVER TO DECIDES WHO THEY

2025
01:19:52,280 --> 01:19:53,840
WILL TREAT, WITH ABLATION,

2026
01:19:53,840 --> 01:19:55,640
REFERRED, SUSPECT CANCER.

2027
01:19:55,640 --> 01:19:57,000
SOUNDS COMPLICATED BUT IT REALLY

2028
01:19:57,000 --> 01:20:00,840
IS AN APP THAT TAKES THE BEST OF

2029
01:20:00,840 --> 01:20:03,360
OUR KNOWLEDGE AND PRESENTS EASY

2030
01:20:03,360 --> 01:20:03,800
CHOICES.

2031
01:20:03,800 --> 01:20:05,120
AND IT JUST BASICALLY WORKS LIKE

2032
01:20:05,120 --> 01:20:07,840
THIS KIND OF A CURVE, WHERE YOU

2033
01:20:07,840 --> 01:20:10,000
TAKE THE WORST AND DEFINITELY

2034
01:20:10,000 --> 01:20:12,440
TREAT THEM AND FIND FOR YOUR OWN

2035
01:20:12,440 --> 01:20:13,560
SETTING HOW YOU'RE GOING TO

2036
01:20:13,560 --> 01:20:16,520
TREAT AND YOU PUT THAT INTO THE

2037
01:20:16,520 --> 01:20:16,720
APP.

2038
01:20:16,720 --> 01:20:18,880
AND THAT'S A LOCAL USE.

2039
01:20:18,880 --> 01:20:21,320
SO, WHEN WE TALK ABOUT HOW DOES

2040
01:20:21,320 --> 01:20:23,320
THIS ALL AFFECT HEALTH DECISION

2041
01:20:23,320 --> 01:20:26,080
ANALYSIS, BASED ON ALL OF OUR

2042
01:20:26,080 --> 01:20:26,680
IMPROVED TRANSITION

2043
01:20:26,680 --> 01:20:29,160
PROBABILITIES, WE ARE NO LONGER

2044
01:20:29,160 --> 01:20:30,280
CALIBRATING MUCH.

2045
01:20:30,280 --> 01:20:33,120
WE'VE OBSERVED THINGS FOR 20

2046
01:20:33,120 --> 01:20:33,320
YEARS.

2047
01:20:33,320 --> 01:20:36,320
SO 20-YEAR COHORTS OVER THE LIFE

2048
01:20:36,320 --> 01:20:37,600
COURSE GIVES US VERY GOOD

2049
01:20:37,600 --> 01:20:38,520
TRANSITION RISKS.

2050
01:20:38,520 --> 01:20:42,560
WHICH MEANS IT'S HIGHLY RELIABLE

2051
01:20:42,560 --> 01:20:44,080
AND CAN DO COUNTER-FACTUALS OF

2052
01:20:44,080 --> 01:20:45,800
PREDICTING WHAT WOULD BE OF THIS

2053
01:20:45,800 --> 01:20:48,880
OR THAT WITH A FAIR DEGREE OF

2054
01:20:48,880 --> 01:20:51,160
CONFIDENCE THAT IT'S TRUE.

2055
01:20:51,160 --> 01:20:53,160
AND SO, AS OPPOSED TO GUESS

2056
01:20:53,160 --> 01:20:55,720
WORK, IT BECOMES A VERY USEFUL

2057
01:20:55,720 --> 01:20:58,640
ALMOST ACCOUNTING TOOL AS WE

2058
01:20:58,640 --> 01:20:59,960
PLAN HEALTH DECISIONS.

2059
01:20:59,960 --> 01:21:02,480
BY DIRECT MEASUREMENT OF THESE

2060
01:21:02,480 --> 01:21:04,840
WE NEED LESS CALIBRATION, AND

2061
01:21:04,840 --> 01:21:05,520
GET INCREASED TRUST AND

2062
01:21:05,520 --> 01:21:08,720
INCREASED VALUE FOR HEALTH

2063
01:21:08,720 --> 01:21:08,960
DECISIONS.

2064
01:21:08,960 --> 01:21:11,360
IT TURNS OUT THAT VALUE OF

2065
01:21:11,360 --> 01:21:12,480
HEALTH DECISION MODELING DEPENDS

2066
01:21:12,480 --> 01:21:13,560
HOW MUCH YOU ALREADY KNOW AND

2067
01:21:13,560 --> 01:21:15,120
THEN IT'S JUST A MATTER OF THE

2068
01:21:15,120 --> 01:21:18,840
MATH WHICH IS A VERY GOOD MATH

2069
01:21:18,840 --> 01:21:21,120
TECHNIQUE OF INTEGRATING RISKS

2070
01:21:21,120 --> 01:21:23,200
OVER TIME FOR THINGS WE CAN'T DO

2071
01:21:23,200 --> 01:21:27,840
TRIALS ON.

2072
01:21:27,840 --> 01:21:28,960
IN CONCLUSION, WE'VE HAD A

2073
01:21:28,960 --> 01:21:31,040
WONDERFUL RUN OF LUCK AND WE'VE

2074
01:21:31,040 --> 01:21:31,680
ALSO HAVE DOUG.

2075
01:21:31,680 --> 01:21:33,480
I WANT TO HAVE THIS OCCASION TO

2076
01:21:33,480 --> 01:21:34,080
THANK HIM.

2077
01:21:34,080 --> 01:21:37,400
THIS IS THE THIRD TIME I'VE

2078
01:21:37,400 --> 01:21:39,640
PRESENTED, EACH OF THOSE PHASES

2079
01:21:39,640 --> 01:21:40,920
I PRESENTED ONCE.

2080
01:21:40,920 --> 01:21:43,160
WE'RE NOW AT THIS POINT 40 YEARS

2081
01:21:43,160 --> 01:21:44,840
IN, THE REASON I HAVE 40 YEARS

2082
01:21:44,840 --> 01:21:46,920
IS BECAUSE WE HAVE SOMEBODY WITH

2083
01:21:46,920 --> 01:21:48,320
CONTINUITY WHO HAS SEEN A VISION

2084
01:21:48,320 --> 01:21:50,680
OVER THAT TIME.

2085
01:21:50,680 --> 01:21:53,240
HE'S HAD ALL THE PRAISE HE

2086
01:21:53,240 --> 01:21:55,400
NEEDS, DOESN'T NEED MINE BUT I'M

2087
01:21:55,400 --> 01:21:58,040
NO NONSENSE, HE DESERVES MY

2088
01:21:58,040 --> 01:21:59,040
THANKS AS WELL.

2089
01:21:59,040 --> 01:22:04,240
WE'VE DONE ENOUGH WITH  CERVIX

2090
01:22:04,240 --> 01:22:06,120
THAT IT'S A MODEL.

2091
01:22:06,120 --> 01:22:07,200
KAISER PERMANENTE NORTHERN

2092
01:22:07,200 --> 01:22:11,680
CALIFORNIA, OR LIVING IN

2093
01:22:11,680 --> 01:22:13,240
AUSTRALIA WE'VE MADE CERVICAL

2094
01:22:13,240 --> 01:22:15,320
CANCER A RARE DISEASE, THAT

2095
01:22:15,320 --> 01:22:16,720
COULD BE EVERYWHERE, IT'S

2096
01:22:16,720 --> 01:22:19,560
ACHIEVABLE, A MATTER OF

2097
01:22:19,560 --> 01:22:20,560
IMPLEMENTATION OF WILL.

2098
01:22:20,560 --> 01:22:22,960
BECAUSE IT'S SUCH A RISK MAINLY

2099
01:22:22,960 --> 01:22:26,320
TO PEOPLE AT RISK, IT'S AN ISSUE

2100
01:22:26,320 --> 01:22:26,600
OF JUSTICE.

2101
01:22:26,600 --> 01:22:28,760
IT'S ALWAYS BEEN THAT NOW, NOW

2102
01:22:28,760 --> 01:22:29,640
INCREASINGLY THAT WAY.

2103
01:22:29,640 --> 01:22:31,360
I THANK HIM AND THANK YOU FOR

2104
01:22:31,360 --> 01:22:33,840
YOUR ATTENTION AND IF YOU HAVE

2105
01:22:33,840 --> 01:22:38,760
ANY TECHNICAL QUESTIONS, NICOLE

2106
01:22:38,760 --> 01:22:41,480
IS HERE FOR THE COST

2107
01:22:41,480 --> 01:22:44,760
EFFECTIVENESS STUFF.

2108
01:22:44,760 --> 01:22:52,120
THANKS. 

2109
01:22:52,120 --> 01:22:53,000
>> THANK YOU, MARK.

2110
01:22:53,000 --> 01:22:55,840
THE FLOOR IS OPEN FOR QUESTIONS

2111
01:22:55,840 --> 01:22:56,720
OF MARK.

2112
01:22:56,720 --> 01:23:01,240
I'M ALWAYS INTERESTED IN SEEING

2113
01:23:01,240 --> 01:23:04,560
THE MATH, HAVING GROWN UP IN THE

2114
01:23:04,560 --> 01:23:07,880
MISSISSIPPI DELTA WONDERING WHY 

2115
01:23:07,880 --> 01:23:13,680
IT PERSISTS AS SUCH A  REGION

2116
01:23:13,680 --> 01:23:15,520
WITH HIGH RATES, AND CAN THIS

2117
01:23:15,520 --> 01:23:22,600
MODEL OR A MODEL LIKE THIS MOVE

2118
01:23:22,600 --> 01:23:23,560
THE NEEDLE WHERE THERE'S ISSUES

2119
01:23:23,560 --> 01:23:27,240
RELATIVE TO EDUCATION, WHAT IS

2120
01:23:27,240 --> 01:23:28,480
HPV, CERVICAL CANCER, HOW WILL

2121
01:23:28,480 --> 01:23:30,720
IT IMPACT ME AND MY FAMILY

2122
01:23:30,720 --> 01:23:32,800
MEMBERS.

2123
01:23:32,800 --> 01:23:35,760
I THINK THERE'S A HUGE GAP,

2124
01:23:35,760 --> 01:23:37,040
TRYING TO IMPLEMENT THESE

2125
01:23:37,040 --> 01:23:38,000
APPROACHES MAY BE MORE DIFFICULT

2126
01:23:38,000 --> 01:23:44,040
IN THOSE TYPES OF SETTINGS.

2127
01:23:44,040 --> 01:23:44,640
>> COMPLETELY TRUE.

2128
01:23:44,640 --> 01:23:46,600
WHEN WE GO AROUND THE WORLD IN

2129
01:23:46,600 --> 01:23:48,200
AFRICA OR WHATEVER AND SAY TRUST

2130
01:23:48,200 --> 01:23:52,680
ME, WE'RE GOING TO BE USING HPV

2131
01:23:52,680 --> 01:23:53,560
SCIENCE AND ARTIFICIAL

2132
01:23:53,560 --> 01:23:55,200
INTELLIGENCE TO PREDICT WHETHER

2133
01:23:55,200 --> 01:23:58,520
YOU'RE AT RISK AND NEED SURGICAL

2134
01:23:58,520 --> 01:23:59,720
PROCEDURE OR NOT.

2135
01:23:59,720 --> 01:24:03,000
YOU FEEL FINE BUT YOU NEED

2136
01:24:03,000 --> 01:24:03,360
SOMETHING.

2137
01:24:03,360 --> 01:24:04,760
WE'VE BEEN IN NIGERIA AND HAD

2138
01:24:04,760 --> 01:24:08,640
THE WHOLE TOWN SAY NO THANKS.

2139
01:24:08,640 --> 01:24:13,040
WE HAVE A REALLY ACTIVE HEALTH

2140
01:24:13,040 --> 01:24:13,360
COMMUNICATION.

2141
01:24:13,360 --> 01:24:13,960
PAUL HAHN AND OTHERS.

2142
01:24:13,960 --> 01:24:15,480
WE'VE GOT TO BE ABLE TO

2143
01:24:15,480 --> 01:24:17,520
COMMUNICATE THE GIST OF WHAT

2144
01:24:17,520 --> 01:24:19,240
WE'RE DOING FOR FAIRNESS AND WE

2145
01:24:19,240 --> 01:24:20,720
HAVE TO UNDERSTAND HOW MUCH

2146
01:24:20,720 --> 01:24:22,280
PEOPLE WANT TO KNOW.

2147
01:24:22,280 --> 01:24:25,680
SINCE THIS IS BASICALLY TAKING

2148
01:24:25,680 --> 01:24:29,200
VERY COMPLEX SCIENCE, BOILING IT

2149
01:24:29,200 --> 01:24:31,080
DOWN, MAKING IT SIMPLE IN

2150
01:24:31,080 --> 01:24:31,320
OUTCOME.

2151
01:24:31,320 --> 01:24:33,280
BUT IF PEOPLE WANT TO KNOW WHAT

2152
01:24:33,280 --> 01:24:36,960
IT IS, QUITE A TASK.

2153
01:24:36,960 --> 01:24:40,400
SO NUMERACY FOR RISK ESTIMATION

2154
01:24:40,400 --> 01:24:41,440
IS NOBODY'S FAVORITE.

2155
01:24:41,440 --> 01:24:43,480
EVERYONE WOULD RATHER NAME

2156
01:24:43,480 --> 01:24:48,120
SOMETHING THAN SAY I HAVE X PER

2157
01:24:48,120 --> 01:24:50,640
CORRECT  -- X% THIS OR THAT.

2158
01:24:50,640 --> 01:24:52,920
WE HAVE A LOT TO DO EVEN WITH A

2159
01:24:52,920 --> 01:24:54,800
VERY EFFECTIVE ANSWER, AND I

2160
01:24:54,800 --> 01:25:03,000
KNOW THAT'S THE WHOLE THING FOR

2161
01:25:03,000 --> 01:25:03,400
IMPLEMENTATION.

2162
01:25:03,400 --> 01:25:05,800
PATTY GRAVITT IS DOING WORK ON

2163
01:25:05,800 --> 01:25:07,720
THIS PARTICULARLY, HOW MUCH

2164
01:25:07,720 --> 01:25:10,360
SHARED DECISION MAKING IS TO BE

2165
01:25:10,360 --> 01:25:12,320
EXPECTED AND DESIRED, AND HOW

2166
01:25:12,320 --> 01:25:14,160
FLEXIBLE CAN WE MAKE THIS SO

2167
01:25:14,160 --> 01:25:22,720
THAT PEOPLE CAN TRUST IN THEIR 

2168
01:25:22,720 --> 01:25:22,960
CONTEXT.

2169
01:25:22,960 --> 01:25:30,000
>> FRANCIS, I SEE YOUR
HAND.

2170
01:25:30,000 --> 01:25:30,640
>> THAT'S WONDERFUL.

2171
01:25:30,640 --> 01:25:32,000
THE CASE IN AFRICA, AND

2172
01:25:32,000 --> 01:25:34,600
MARGARET, YOU CAN HELP ME OUT

2173
01:25:34,600 --> 01:25:38,720
HERE, IS THAT IT HAPPENED WITH 

2174
01:25:38,720 --> 01:25:42,600
MAMMOGRAPHY, ALL THESE TESTS

2175
01:25:42,600 --> 01:25:46,800
THAT IDENTIFY HIGH RISK AND

2176
01:25:46,800 --> 01:25:50,800
POTENTIALLY HIGH RISK IS THE

2177
01:25:50,800 --> 01:25:51,120
CONTINUUM.

2178
01:25:51,120 --> 01:25:53,560
s YOU COULD THE TEST, IT'S

2179
01:25:53,560 --> 01:25:53,840
POSITIVE.

2180
01:25:53,840 --> 01:25:55,800
IT ENDS THERE.

2181
01:25:55,800 --> 01:25:57,200
UNTIL EFFORTS ARE MADE INTO

2182
01:25:57,200 --> 01:26:03,960
INTERVENTION, THERE'S GOING TO

2183
01:26:03,960 --> 01:26:06,320
BE AN -- (INDISCERNIBLE) TO

2184
01:26:06,320 --> 01:26:07,400
SETTLE IN THESE COUNTRIES,

2185
01:26:07,400 --> 01:26:08,800
POSSIBLY EVEN THE MISSISSIPPI

2186
01:26:08,800 --> 01:26:11,320
DELTA THAT JOHN WAS TALKING

2187
01:26:11,320 --> 01:26:12,640
ABOUT, EITHER WORKING WITH THE

2188
01:26:12,640 --> 01:26:16,160
GOVERNMENTS OR WHATEVER TO MAKE

2189
01:26:16,160 --> 01:26:18,120
SURE THAT PEOPLE ARE FOUND TO BE

2190
01:26:18,120 --> 01:26:19,360
HIGH RISK OR POSITIVE THAT THERE

2191
01:26:19,360 --> 01:26:21,400
IS AN OPTION FOR THEM.

2192
01:26:21,400 --> 01:26:22,840
IF THAT'S NOT THERE, I THINK

2193
01:26:22,840 --> 01:26:24,400
THERE'S GOING TO BE

2194
01:26:24,400 --> 01:26:25,240
CONTINUING -- THE QUESTION IS

2195
01:26:25,240 --> 01:26:27,040
HOW DOES THAT HELP MY LIFE.

2196
01:26:27,040 --> 01:26:29,800
HOW DOES IT CHANGE ANYTHING FOR

2197
01:26:29,800 --> 01:26:30,160
ME?

2198
01:26:30,160 --> 01:26:33,680
>> NOTICE THE DEVICE THAT
IS THE

2199
01:26:33,680 --> 01:26:36,280
ABLATION DEVICE IS THE DEVICE

2200
01:26:36,280 --> 01:26:37,840
THAT TAKES THE HPV TYPE,

2201
01:26:37,840 --> 01:26:39,440
INTEGRATES THE INFORMATION OF

2202
01:26:39,440 --> 01:26:41,760
WHAT IT SEES, HAS A CAMERA, AND

2203
01:26:41,760 --> 01:26:44,960
SAYS WILL THIS DEVICE WORK FOR

2204
01:26:44,960 --> 01:26:46,560
THIS, FOR YOU, OR DO YOU NEED

2205
01:26:46,560 --> 01:26:52,720
REFERRAL. 

2206
01:26:52,720 --> 01:27:03,080
WE TIE THEM TOGETHER.

2207
01:27:16,400 --> 01:27:22,160
>> MAMMOGRAPHY DIDN'T PICK
UP, 

2208
01:27:22,160 --> 01:27:23,960
TO HAVE DONE POTENTIALLY.

2209
01:27:23,960 --> 01:27:25,080
>> MARGARET?

2210
01:27:25,080 --> 01:27:29,720
>> THANK YOU.

2211
01:27:29,720 --> 01:27:32,920
>> EXCELLENT PRESENTATION,
MARK.

2212
01:27:32,920 --> 01:27:34,800
ALL REFERRING CANCERS, LIKEWISE

2213
01:27:34,800 --> 01:27:37,440
CERTAIN ARE ASSOCIATED WITH HPV,

2214
01:27:37,440 --> 01:27:45,080
WONDERING SOMEONE HAS CONSIDERED

2215
01:27:45,080 --> 01:27:47,040
A SIMILAR APPROACH, THERE WERE

2216
01:27:47,040 --> 01:27:47,680
PRE-CANCER LESIONS.

2217
01:27:47,680 --> 01:27:49,000
SUCH AN APPROACH COULD BE TAKEN

2218
01:27:49,000 --> 01:27:57,360
WITH THIS DISEASE AS WELL, ALSO 

2219
01:27:57,360 --> 01:27:58,440
A VERY EXCITING OPPORTUNITY.

2220
01:27:58,440 --> 01:27:59,920
>> THAT'S A SPECIAL AREA
OF

2221
01:27:59,920 --> 01:28:00,560
INTEREST.

2222
01:28:00,560 --> 01:28:06,560
I WOULD POINT OUT THERE IS NO

2223
01:28:06,560 --> 01:28:08,840
PRE-CANCEROUS STATE WELL

2224
01:28:08,840 --> 01:28:11,000
IDENTIFIED, WE HAVE A VERY LONG

2225
01:28:11,000 --> 01:28:13,000
SOJOURN TIME WHERE WE CAN CATCH

2226
01:28:13,000 --> 01:28:15,720
AND DESTROY A PRE-CANCER OF THE

2227
01:28:15,720 --> 01:28:16,280
CERVIX.

2228
01:28:16,280 --> 01:28:19,400
AND WE'RE WORKING ALSO ON THE

2229
01:28:19,400 --> 01:28:20,120
ADENOS, GLANDULARES, LEARNING

2230
01:28:20,120 --> 01:28:22,120
MORE ABOUT RIGHT NOW.

2231
01:28:22,120 --> 01:28:24,520
WE DON'T HAVE WHAT WE'RE

2232
01:28:24,520 --> 01:28:28,120
TARGETING, OFTEN THE FIRST SIGN

2233
01:28:28,120 --> 01:28:36,480
OF  OROPHARYNGEAL, EXTENSION OF

2234
01:28:36,480 --> 01:28:39,080
THE NECK, OFTEN NOTHING SEEN SO

2235
01:28:39,080 --> 01:28:47,400
FINDING THAT SURROGATE ENDPOINT 

2236
01:28:47,400 --> 01:28:49,760
PRECURSOR WOULD BE A STEP UP FOR

2237
01:28:49,760 --> 01:28:52,480
THAT SCREENING EFFORT.

2238
01:28:52,480 --> 01:28:54,200
 

2239
01:28:54,200 --> 01:28:57,640
>> THANKS, MARK.

2240
01:28:57,640 --> 01:28:59,000
ONE LAST QUESTION, AS WE

2241
01:28:59,000 --> 01:29:03,480
CONTINUE TO SEE DEVELOPMENT OF

2242
01:29:03,480 --> 01:29:05,800
NEW NON-INVASIVE APPROACHES FOR

2243
01:29:05,800 --> 01:29:06,800
CANCER DETECTION, PRE-CANCEROUS

2244
01:29:06,800 --> 01:29:09,520
AS WELL FOR VARIOUS FORMS OF

2245
01:29:09,520 --> 01:29:11,560
CANCER, WHERE ARE WE WITH

2246
01:29:11,560 --> 01:29:12,800
CERVICAL CANCER?

2247
01:29:12,800 --> 01:29:16,080
DO WE SEE NOVEL APPROACHES

2248
01:29:16,080 --> 01:29:18,920
COMING ONLINE THAT MIGHT BE EVEN

2249
01:29:18,920 --> 01:29:28,520
MORE NON-INVASIVE TO DETECT

2250
01:29:28,520 --> 01:29:29,600
THESE CANCERS?

2251
01:29:29,600 --> 01:29:31,040
AS WE THINK ABOUT MICROBIOME AND

2252
01:29:31,040 --> 01:29:32,520
OTHER APPROACHES TO COME UP WITH

2253
01:29:32,520 --> 01:29:37,720
NEW AND BETTER WAYS TO DETECT

2254
01:29:37,720 --> 01:29:38,720
THESE PRE-CANCERS.

2255
01:29:38,720 --> 01:29:40,600
>> FIRST OF ALL, THE
REASSURANCE

2256
01:29:40,600 --> 01:29:44,720
GIVEN TO 90% OF PEOPLE BY A

2257
01:29:44,720 --> 01:29:45,400
SELF-SWAB, A BACKGROUND, YOU

2258
01:29:45,400 --> 01:29:47,560
KNOW, I MEAN IT'S A SPECIAL

2259
01:29:47,560 --> 01:29:50,640
PLASTIC BUT IT'S A BEAUTIFUL

2260
01:29:50,640 --> 01:29:55,280
LITTLE SWAB THAT'S BEING MADE,

2261
01:29:55,280 --> 01:29:56,440
CUSTOM MADE, IT'S -- THE

2262
01:29:56,440 --> 01:30:04,520
POSITIVES COME UP IN TEN

2263
01:30:04,520 --> 01:30:04,720
MINUTES.

2264
01:30:04,720 --> 01:30:08,640
WEAKEST SIGNALS TO 50 MINUTES.

2265
01:30:08,640 --> 01:30:12,160
A 10-MINUTE TEST FOR $5, 10 TO

2266
01:30:12,160 --> 01:30:14,720
50 MINUTES, DONE BY A WOMAN AND

2267
01:30:14,720 --> 01:30:15,560
HANDED IN.

2268
01:30:15,560 --> 01:30:16,880
THAT REASSURANCE TWICE IN A

2269
01:30:16,880 --> 01:30:18,640
LIFETIME IS A BIG ADVANCE.

2270
01:30:18,640 --> 01:30:21,240
THEN THE FACT THAT WE NOW HAVE A

2271
01:30:21,240 --> 01:30:26,480
VARIETY OF REALLY GOOD TRIAGE

2272
01:30:26,480 --> 01:30:28,120
TOOLS, METHYLATION, DUAL STAIN,

2273
01:30:28,120 --> 01:30:30,320
HPV TYPING, A HOST.

2274
01:30:30,320 --> 01:30:31,960
IT'S JUST A MATTER OF GETTING

2275
01:30:31,960 --> 01:30:33,720
THEM -- IF YOU GIVE ME ENOUGH

2276
01:30:33,720 --> 01:30:35,920
MONEY I CAN TELL IF SOMEONE HAS

2277
01:30:35,920 --> 01:30:36,240
PRE-CANCER.

2278
01:30:36,240 --> 01:30:38,680
IT'S A MATTER OF SCALING AND

2279
01:30:38,680 --> 01:30:40,560
ENGINEERING AND GETTING IT TO

2280
01:30:40,560 --> 01:30:41,960
PEOPLE WHICH TURNS OUT TO BE

2281
01:30:41,960 --> 01:30:44,200
MAJOR CHALLENGES TO GET THINGS

2282
01:30:44,200 --> 01:30:44,600
AFFORDABLE.

2283
01:30:44,600 --> 01:30:46,760
AND ACCEPTED.

2284
01:30:46,760 --> 01:30:50,800
 

2285
01:30:50,800 --> 01:30:51,600
>> YES, KAREN?

2286
01:30:51,600 --> 01:30:53,200
>> THANKS YOU SO MUCH.

2287
01:30:53,200 --> 01:30:58,040
THIS WAS SUCH A GREAT TALK.

2288
01:30:58,040 --> 01:31:00,200
THIS IS ONE WE REALLY CAN CURE,

2289
01:31:00,200 --> 01:31:02,120
PREVENT AND IT'S ONE OF THOSE

2290
01:31:02,120 --> 01:31:03,800
THAT REMINDS ME OF COLORECTAL

2291
01:31:03,800 --> 01:31:05,800
CANCER SCREENING BUT TO JOHN'S

2292
01:31:05,800 --> 01:31:06,600
POINT WHEN I LOOK AT FOR

2293
01:31:06,600 --> 01:31:08,080
INSTANCE A LOT OF EFFORTS THAT

2294
01:31:08,080 --> 01:31:10,200
HAVE BEEN MADE AROUND HEALTH

2295
01:31:10,200 --> 01:31:13,680
EDUCATION THINKING SPECIFICALLY

2296
01:31:13,680 --> 01:31:15,840
OF THE PROGRAMS THE NCI HAS

2297
01:31:15,840 --> 01:31:17,960
FUNDED MANY ARE NOT IN THAT

2298
01:31:17,960 --> 01:31:19,600
BLACK BELT IN THE MISSISSIPPI,

2299
01:31:19,600 --> 01:31:21,040
ALABAMA, THEY ARE ALL IN THE

2300
01:31:21,040 --> 01:31:21,960
NORTHEAST REGION.

2301
01:31:21,960 --> 01:31:24,280
MAYBE PERHAPS THERE'S AN

2302
01:31:24,280 --> 01:31:24,960
OPPORTUNITY TO THINK ABOUT

2303
01:31:24,960 --> 01:31:27,800
CREATING SOME OF THOSE

2304
01:31:27,800 --> 01:31:28,320
EDUCATIONAL OPPORTUNITIES.

2305
01:31:28,320 --> 01:31:29,640
THIS IS NOT ROCKET SCIENCE.

2306
01:31:29,640 --> 01:31:31,320
IN FACT A LOT OF THE

2307
01:31:31,320 --> 01:31:32,480
TECHNOLOGIES THAT YOU'RE TALKING

2308
01:31:32,480 --> 01:31:34,800
ABOUT, NOT WITH THE A.I. BUT

2309
01:31:34,800 --> 01:31:37,680
WITH THE POINT OF SERVICE CARE,

2310
01:31:37,680 --> 01:31:38,720
IT'S REVERSE INNOVATION.

2311
01:31:38,720 --> 01:31:40,120
THEY HAVE BEEN DOING IT IN

2312
01:31:40,120 --> 01:31:41,920
BOTSWANA FOR YEARS, A PROVIDER

2313
01:31:41,920 --> 01:31:43,120
IS LOOKING, NOT EVEN A PHYSICIAN

2314
01:31:43,120 --> 01:31:45,720
PROVIDER, SOMEONE WHO IS A

2315
01:31:45,720 --> 01:31:48,040
LAYPERSON TRAINED TO LOOK AT IT,

2316
01:31:48,040 --> 01:31:51,120
THERE'S A PHYSICIAN SOMEWHERE

2317
01:31:51,120 --> 01:31:53,520
ELSE LOOKING THAT SAYS OKAY THIS

2318
01:31:53,520 --> 01:31:57,160
PERSON NEEDS SOME VINEGAR WHICH

2319
01:31:57,160 --> 01:31:58,600
IS ESSENTIALLY TREATMENT, RIGHT?

2320
01:31:58,600 --> 01:32:01,480
TO YOUR POINT, LOW COST

2321
01:32:01,480 --> 01:32:02,240
INTERVENTIONS THAT REALLY WORK,

2322
01:32:02,240 --> 01:32:03,800
THE BIGGEST THING THAT WE CAN

2323
01:32:03,800 --> 01:32:06,040
THINK ABOUT IS HOW TO DO THE

2324
01:32:06,040 --> 01:32:07,520
EDUCATION, HOW DO WE LEVERAGE

2325
01:32:07,520 --> 01:32:11,040
THE RESOURCES THAT ARE ALREADY

2326
01:32:11,040 --> 01:32:11,600
OUT THERE PARTICULARLY THE

2327
01:32:11,600 --> 01:32:14,120
NON-CHI PROGRAM BECAUSE THAT WAS

2328
01:32:14,120 --> 01:32:17,320
ONE OF THE BIG PUSHES.

2329
01:32:17,320 --> 01:32:19,200
NCI SAID HPV, GET THE WORD OUT

2330
01:32:19,200 --> 01:32:20,120
ABOUT PREVENTION AND SCREENING.

2331
01:32:20,120 --> 01:32:24,720
I THINK THIS IS A WONDERFUL,

2332
01:32:24,720 --> 01:32:26,640
WONDERFUL EXAMPLE OF INNOVATIONS

2333
01:32:26,640 --> 01:32:27,680
THAT UNFORTUNATELY MAY BYPASS

2334
01:32:27,680 --> 01:32:30,080
THOSE COMMUNITIES THAT HAVE BEEN

2335
01:32:30,080 --> 01:32:30,960
TRADITIONALLY UNDERSERVED AND WE

2336
01:32:30,960 --> 01:32:33,120
NEED TO PUT OUR MINDS TOGETHER

2337
01:32:33,120 --> 01:32:34,000
TO LEVERAGE OUR CURRENT

2338
01:32:34,000 --> 01:32:34,960
RESOURCES TO ADDRESS SOME OF

2339
01:32:34,960 --> 01:32:35,520
THOSE ISSUES.

2340
01:32:35,520 --> 01:32:40,080
THANK YOU FOR A GREAT TALK.

2341
01:32:40,080 --> 01:32:43,440
>> TO TARGET THEM
SPECIFICALLY, 

2342
01:32:43,440 --> 01:32:45,200
GO TO THE HIGHEST BECAUSE THESE

2343
01:32:45,200 --> 01:32:45,520
WORK ANYWHERE.

2344
01:32:45,520 --> 01:32:47,320
AS SOON AS YOU KNOW A PLACE IS

2345
01:32:47,320 --> 01:32:49,160
HIGH RISK TREAT IT LIKE THE

2346
01:32:49,160 --> 01:32:50,640
EPIDEMIC THAT IT IS.

2347
01:32:50,640 --> 01:32:51,320
GO THERE.

2348
01:32:51,320 --> 01:32:53,840
AND BREAK IT DOWN FROM THERE

2349
01:32:53,840 --> 01:32:55,360
BECAUSE REDUCING SOMETHING 10%

2350
01:32:55,360 --> 01:32:58,640
FROM A HIGH RATE SAVES A LOT

2351
01:32:58,640 --> 01:32:59,320
MORE LIVES THAN REDUCING

2352
01:32:59,320 --> 01:33:03,160
SOMETHING 10% FROM A LOW RATE.

2353
01:33:03,160 --> 01:33:06,760
>> I COULDN'T AGREE MORE,
KAREN.

2354
01:33:06,760 --> 01:33:08,440
I THINK THERE'S A GRASSROOTS

2355
01:33:08,440 --> 01:33:10,560
EFFORT THAT WILL BE NEEDED TO

2356
01:33:10,560 --> 01:33:11,000
ADDRESS THIS.

2357
01:33:11,000 --> 01:33:13,440
AND SOME OF THESE PLACES LIKE

2358
01:33:13,440 --> 01:33:17,080
THE MISSISSIPPI DELTA.

2359
01:33:17,080 --> 01:33:17,600
SUSAN?

2360
01:33:17,600 --> 01:33:19,440
>> JUST BECAUSE I SO
AGREE, THIS

2361
01:33:19,440 --> 01:33:24,520
IS AN IMPORTANT POINT, IN

2362
01:33:24,520 --> 01:33:28,560
THINKING ABOUT PARTNERS WHEN YOU

2363
01:33:28,560 --> 01:33:38,880
WERE WORKING IN THESE

2364
01:33:38,880 --> 01:33:40,040
LOW-RESOURCE SETTINGS

2365
01:33:40,040 --> 01:33:41,680
COMMUNITY SETTINGS, THE FOLKS

2366
01:33:41,680 --> 01:33:43,040
SERVING THOSE COMMUNITIES, NICE

2367
01:33:43,040 --> 01:33:46,120
TO SEE LIKE I'VE SEEN IN

2368
01:33:46,120 --> 01:33:47,840
LEGISLATION WITH A PUSH TO HAVE

2369
01:33:47,840 --> 01:33:51,080
THOSE CENTERS ACTUALLY BE ABLE

2370
01:33:51,080 --> 01:33:52,280
TO RECEIVE THOSE TYPES OF FUNDS

2371
01:33:52,280 --> 01:33:55,520
TO DO SOME OF THE HEALTH

2372
01:33:55,520 --> 01:33:56,240
EDUCATION AND OUTREACH BECAUSE

2373
01:33:56,240 --> 01:33:59,440
THEY ARE THE TRUSTED PARTNERS IN

2374
01:33:59,440 --> 01:34:01,880
THE COMMUNITY ALREADY THERE.

2375
01:34:01,880 --> 01:34:05,120
SO, I WOULD LOVE TO SEE THIS

2376
01:34:05,120 --> 01:34:10,640
ADVANCE IN THE U.S. AND IN

2377
01:34:10,640 --> 01:34:12,400
UNDERSERVED AREAS.

2378
01:34:12,400 --> 01:34:13,080
>> THAT'S TRUE.

2379
01:34:13,080 --> 01:34:14,880
>> I AGREE TOTALLY.

2380
01:34:14,880 --> 01:34:15,680
ELECTRA?

2381
01:34:15,680 --> 01:34:16,360
>> THANKS, MARK.

2382
01:34:16,360 --> 01:34:16,840
HI, MARK.

2383
01:34:16,840 --> 01:34:17,600
GOOD TO SEE YOU.

2384
01:34:17,600 --> 01:34:20,360
THANKS FOR ALL YOU DO.

2385
01:34:20,360 --> 01:34:21,880
SO, SOMEBODY WHO HAS WORKED FOR

2386
01:34:21,880 --> 01:34:24,600
OVER 30 YEARS IN THIS AREA OF

2387
01:34:24,600 --> 01:34:26,440
CERVICAL CANCER, I CAN TELL YOU

2388
01:34:26,440 --> 01:34:33,120
IT'S GOING TO TAKE MORE THAN

2389
01:34:33,120 --> 01:34:34,600
JUST EDUCATION.

2390
01:34:34,600 --> 01:34:35,520
EVEN ACCESS.

2391
01:34:35,520 --> 01:34:37,160
W.H.O., SEVERAL YEARS AGO SAID

2392
01:34:37,160 --> 01:34:46,000
THERE'S THREE PILLARS  THAT LED 

2393
01:34:46,000 --> 01:34:51,960
LEAD TO ELIMINATION, SCREENING

2394
01:34:51,960 --> 01:34:52,840
AND TIMELY FOLLOW-UP.

2395
01:34:52,840 --> 01:34:55,080
IN THE UNITED STATES WE'RE

2396
01:34:55,080 --> 01:34:56,880
FALLING SHORT, BIG TIME, OF THE

2397
01:34:56,880 --> 01:34:57,760
LAST ONE.

2398
01:34:57,760 --> 01:35:01,320
WHEN I GOT MY DISSERTATION

2399
01:35:01,320 --> 01:35:06,120
FINISHED IN 1989, THE RATE OF

2400
01:35:06,120 --> 01:35:08,240
FOLLOW-UP OF ABNORMAL PAPS WAS

2401
01:35:08,240 --> 01:35:08,400
60%.

2402
01:35:08,400 --> 01:35:09,800
WENT TO A MEETING A COUPLE

2403
01:35:09,800 --> 01:35:12,560
MONTHS AGO, THE RATE IS STILL

2404
01:35:12,560 --> 01:35:17,400
60% FOR WOMEN WITH ABNORMALS. 

2405
01:35:17,400 --> 01:35:19,920
THAT'S JUST UNACCEPTABLE.

2406
01:35:19,920 --> 01:35:22,720
AND UNTIL WE UNDERSTAND THAT

2407
01:35:22,720 --> 01:35:25,120
THESE WOMEN ALL COUNT, THAT WE

2408
01:35:25,120 --> 01:35:28,000
HEALTH CARE PROVIDERS ARE

2409
01:35:28,000 --> 01:35:29,080
RESPONSIBLE FOR FOLLOW-UP,

2410
01:35:29,080 --> 01:35:30,760
TIMELY AND PROPER FOLLOW-UP OF

2411
01:35:30,760 --> 01:35:36,600
THE WOMEN, THAT WE NEED TO FOCUS

2412
01:35:36,600 --> 01:35:39,560
ON THIS.

2413
01:35:39,560 --> 01:35:43,440
WE'RE NOT 

2414
01:35:43,440 --> 01:35:45,120
WE'RE NOT GOING TO GET ANYWHERE,

2415
01:35:45,120 --> 01:35:46,800
DOESN'T HELP TO SCREEN WITHOUT

2416
01:35:46,800 --> 01:35:47,080
FOLLOW-UP.

2417
01:35:47,080 --> 01:35:48,720
UNFORTUNATELY WOMEN WHO DON'T

2418
01:35:48,720 --> 01:35:53,920
SPEAK ENGLISH ARE EXPERIENCING A

2419
01:35:53,920 --> 01:35:56,560
HUGE DISPARITY BECAUSE A LOT OF

2420
01:35:56,560 --> 01:35:58,760
INFORMATION IS IN ENGLISH, NO

2421
01:35:58,760 --> 01:36:03,480
HELP TO GET THE APPROPRIATE

2422
01:36:03,480 --> 01:36:04,120
FOLLOW-UP SERVICES.

2423
01:36:04,120 --> 01:36:05,880
I THINK WE CAN ELIMINATE

2424
01:36:05,880 --> 01:36:08,120
CERVICAL CANCER BUT THERE HAS TO

2425
01:36:08,120 --> 01:36:12,440
BE A WILL AND EVERYBODY HAS TO

2426
01:36:12,440 --> 01:36:13,960
THINK ABOUT IT, AND WANT TO DO

2427
01:36:13,960 --> 01:36:17,720
IT, AND NOT THINK OF CERVICAL

2428
01:36:17,720 --> 01:36:19,480
CANCER AS SOMETHING THAT ONLY

2429
01:36:19,480 --> 01:36:24,800
CERTAIN WOMEN GET. 

2430
01:36:24,800 --> 01:36:26,280
AND I HAVE HEARD THAT AND WE'VE

2431
01:36:26,280 --> 01:36:31,040
GOT TO CHANGE WAIT WE THINK

2432
01:36:31,040 --> 01:36:34,600
ABOUT IT.  ALSO HELP TO INCREASE

2433
01:36:34,600 --> 01:36:36,720
HPV VACCINATION RATES WHICH

2434
01:36:36,720 --> 01:36:38,960
SUFFERED DON'T COVID AND

2435
01:36:38,960 --> 01:36:39,400
CONTINUE TO SUFFER.

2436
01:36:39,400 --> 01:36:40,920
WE WANT TO MAKE A DIFFERENCE IN

2437
01:36:40,920 --> 01:36:42,560
CANCER, START WITH THE ONE WE

2438
01:36:42,560 --> 01:36:44,320
CAN, PERHAPS A FEW OTHER CANCERS

2439
01:36:44,320 --> 01:36:47,680
ALONG THE WAY.

2440
01:36:47,680 --> 01:36:50,960
BUT THANK YOU, MARK AND DOUG,

2441
01:36:50,960 --> 01:36:53,360
FOR YOUR WORK ON THIS.

2442
01:36:53,360 --> 01:36:55,120
IT'S REALLY SPECTACULAR AND

2443
01:36:55,120 --> 01:36:57,320
WE'VE JUST GOT TO NOW IMPLEMENT

2444
01:36:57,320 --> 01:36:59,840
IT BUT IMPLEMENT IT ON THE

2445
01:36:59,840 --> 01:37:03,760
MULTI-LEVEL FOCUS AND NOT JUST

2446
01:37:03,760 --> 01:37:07,280
THINK ABOUT ACCESS AND EDUCATION

2447
01:37:07,280 --> 01:37:08,680
BECAUSE THERE'S CULTURE, THERE'S

2448
01:37:08,680 --> 01:37:10,480
FEAR, THERE'S A WHOLE LOT OF

2449
01:37:10,480 --> 01:37:12,080
THINGS THAT WE NEED TO FOCUS ON

2450
01:37:12,080 --> 01:37:13,320
AND WE'RE DOING IT.

2451
01:37:13,320 --> 01:37:16,320
WE'VE BEEN DOING IT NOW IN

2452
01:37:16,320 --> 01:37:20,520
APPALACHIA FOR MANY YEARS, IT'S

2453
01:37:20,520 --> 01:37:22,680
NICE THEY DON'T HAVE THE HIGHEST

2454
01:37:22,680 --> 01:37:23,920
RATES ANY LONGER, STILL IN THE

2455
01:37:23,920 --> 01:37:26,360
MID, BUT WE HAVE A LONG WAY TO

2456
01:37:26,360 --> 01:37:27,960
GO TO ELIMINATE THIS CANCER.

2457
01:37:27,960 --> 01:37:29,560
ACHIEVABLE BUT WE HAVE TO WORK

2458
01:37:29,560 --> 01:37:33,800
TOGETHER.

2459
01:37:33,800 --> 01:37:34,400
>> YEAH, EXCELLENT
PERSPECTIVE

2460
01:37:34,400 --> 01:37:35,600
FROM SOMEONE WHO HAS BEEN DOING

2461
01:37:35,600 --> 01:37:37,240
THIS A LONG TIME.

2462
01:37:37,240 --> 01:37:37,440
THANKS.

2463
01:37:37,440 --> 01:37:39,280
I STILL THINK EDUCATION AS WE

2464
01:37:39,280 --> 01:37:42,280
TALK ABOUT FEAR AND TRUST, YOU

2465
01:37:42,280 --> 01:37:43,640
KNOW, CULTURE, RIGHT?

2466
01:37:43,640 --> 01:37:45,360
YOU KNOW, PEOPLE HAVE NO IDEA

2467
01:37:45,360 --> 01:37:47,800
WHAT HPV IS IN THE FIRST PLACE,

2468
01:37:47,800 --> 01:37:51,120
YOU KNOW, WE HAD PEOPLE WHO

2469
01:37:51,120 --> 01:37:53,280
DON'T -- VACCINATION CHALLENGES

2470
01:37:53,280 --> 01:37:56,040
WITH COVID, AND EVERYONE, IT WAS

2471
01:37:56,040 --> 01:37:56,640
EVERYWHERE, RIGHT?

2472
01:37:56,640 --> 01:37:59,760
AND FOR A VIRUS THAT CAUSES

2473
01:37:59,760 --> 01:38:01,000
CANCER, SO FEW PEOPLE IN THE

2474
01:38:01,000 --> 01:38:02,720
MISSISSIPPI DELTA HAVE ANY CLUE

2475
01:38:02,720 --> 01:38:06,400
WHAT IT IS IN THE FIRST PLACE.

2476
01:38:06,400 --> 01:38:07,640
THERE'S PERSISTENT EXPOSURE TO

2477
01:38:07,640 --> 01:38:08,520
THE VIRUS.

2478
01:38:08,520 --> 01:38:10,360
SO GREAT POINTS.

2479
01:38:10,360 --> 01:38:12,800
AND THEN YOUR COMMENT, ELECTRA,

2480
01:38:12,800 --> 01:38:15,720
ABOUT FOLLOW-UP IS SIMILAR TO

2481
01:38:15,720 --> 01:38:16,920
COLORECTAL CANCER AND SCREENING

2482
01:38:16,920 --> 01:38:18,040
AND LUNG CANCER SCREENING, ALL

2483
01:38:18,040 --> 01:38:18,680
THESE THINGS.

2484
01:38:18,680 --> 01:38:20,480
IF YOU CAN FIND IT, GREAT.

2485
01:38:20,480 --> 01:38:22,000
BUT WHAT HAPPENS IF YOU CAN'T DO

2486
01:38:22,000 --> 01:38:23,080
ANYTHING ABOUT IT LATER?

2487
01:38:23,080 --> 01:38:24,680
SO THESE ARE ALL GREAT POINTS.

2488
01:38:24,680 --> 01:38:26,640
BUT THANK YOU AGAIN, MARK.

2489
01:38:26,640 --> 01:38:29,360
THAT WAS SUCH A FABULOUS

2490
01:38:29,360 --> 01:38:29,760
PRESENTATION.

2491
01:38:29,760 --> 01:38:31,760
AND THE BOARD THANKS YOU FOR

2492
01:38:31,760 --> 01:38:34,800
YOUR TIME AND YOUR EFFORTS.

2493
01:38:34,800 --> 01:38:38,600
I THINK WE'RE RIGHT ON TIME,

2494
01:38:38,600 --> 01:38:39,040
PAULETTE.

2495
01:38:39,040 --> 01:38:42,600
I THINK WE'RE SUPPOSED TO GO

2496
01:38:42,600 --> 01:38:46,920
INTO BREAK NOW.

2497
01:38:46,920 --> 01:38:47,880
>> YES.

2498
01:38:47,880 --> 01:38:50,120
>> SO, THERE'S A 30-MINUTE
BREAK

2499
01:38:50,120 --> 01:38:51,480
FOR THIS OPEN SESSION.

2500
01:38:51,480 --> 01:38:52,920
HOWEVER, THOSE AT THE VIRTUAL

2501
01:38:52,920 --> 01:38:55,360
TABLE CAN TAKE A FIVE-MINUTE

2502
01:38:55,360 --> 01:38:58,640
BREAK, DON'T DISCONNECT, JUST 

2503
01:38:58,640 --> 01:39:00,560
TURN OFF YOUR CAMERAS AND MUTE.

2504
01:39:00,560 --> 01:39:03,480
IF YOU'RE NOT MUTED I.T.

2505
01:39:03,480 --> 01:39:04,600
PROFESSIONALS WILL MUTE

2506
01:39:04,600 --> 01:39:05,000
EVERYONE.

2507
01:39:05,000 --> 01:39:08,240
EVERYONE ELSE SHOULD COME BACK

2508
01:39:08,240 --> 01:39:10,240
AT 3:25.

2509
01:39:10,240 --> 01:39:12,000
FOR THOSE AT THE VIRTUAL TABLE

2510
01:39:12,000 --> 01:39:12,720
JUST TAKE A FIVE-MINUTE BREAK.

2511
01:39:12,720 --> 01:39:19,600
>>I THINK WE'RE BACK IN

2512
01:39:19,600 --> 01:39:19,800
SESSION.

2513
01:39:19,800 --> 01:39:24,040
AND WE'RE NOW IN THE SESSION FOR

2514
01:39:24,040 --> 01:39:26,240
ONGOING AND NEW BUSINESS, AMONG

2515
01:39:26,240 --> 01:39:29,840
WHICH THERE WERE TWO NCAB

2516
01:39:29,840 --> 01:39:30,480
SUBCOMMITTEE MEETINGS HELD

2517
01:39:30,480 --> 01:39:31,360
EARLIER TODAY, AND CHAIRS WILL

2518
01:39:31,360 --> 01:39:31,920
GIVE THEIR REPORTS.

2519
01:39:31,920 --> 01:39:42,240
WE'LL HAVE THE FIRST REPORT FROM

2520
01:39:42,240 --> 01:39:50,720
AMY HEIMBERGER ON EXPERIMENTAL

2521
01:39:50,720 --> 01:39:51,440
THERAPEUTICS?

2522
01:39:51,440 --> 01:39:53,480
>> THERAPEUTICS BEGAN BY
GIVING

2523
01:39:53,480 --> 01:39:55,200
AN UPDATE WITH REGARDS TO

2524
01:39:55,200 --> 01:39:56,320
PREVIOUS MANDATE UNDER DR.

2525
01:39:56,320 --> 01:39:56,600
SHARPLESS.

2526
01:39:56,600 --> 01:39:58,840
THERE WAS SOME CONCERNS WITH

2527
01:39:58,840 --> 01:40:00,120
REGARDS TO DEVELOPMENT 6

2528
01:40:00,120 --> 01:40:01,040
CELLULAR THERAPEUTICS AND HOW

2529
01:40:01,040 --> 01:40:04,960
THE NCI COULD DO THAT BETTER.

2530
01:40:04,960 --> 01:40:06,920
ROSE ARGININE PRESENTED AN

2531
01:40:06,920 --> 01:40:09,120
UPDATE ON CELLULAR THERAPEUTICS

2532
01:40:09,120 --> 01:40:10,760
FOR SOLID CANCERS, THIS INCLUDED

2533
01:40:10,760 --> 01:40:12,320
A NUMBER OF CONFERENCES AS WELL

2534
01:40:12,320 --> 01:40:15,760
AS A WHITE PAPER THAT WAS

2535
01:40:15,760 --> 01:40:18,240
PUBLISHED THAT IDENTIFIED AREAS

2536
01:40:18,240 --> 01:40:20,720
ON UNMET NEED FOR ADVANCING

2537
01:40:20,720 --> 01:40:26,160
CELLULAR THERAPIES FOR SOLID 

2538
01:40:26,160 --> 01:40:26,400
CANCERS.

2539
01:40:26,400 --> 01:40:28,080
THIS ULTIMATELY RESULTED IN

2540
01:40:28,080 --> 01:40:30,480
THREE COMPANION FUNDING

2541
01:40:30,480 --> 01:40:31,680
OPPORTUNITY ANNOUNCEMENTS THAT

2542
01:40:31,680 --> 01:40:37,680
CAME FOR THE CANCER ADOPTIVE

2543
01:40:37,680 --> 01:40:38,840
CELL THERAPY NETWORK, POSTED,

2544
01:40:38,840 --> 01:40:42,480
ONE WILL INCLUDE A COOPERATIVE

2545
01:40:42,480 --> 01:40:44,880
AGREEMENT UG3 AND UH3 THAT WILL

2546
01:40:44,880 --> 01:40:45,920
INCLUDE ADULT AND PEDIATRIC

2547
01:40:45,920 --> 01:40:47,720
CANCERS AND IT'S GOING TO BE

2548
01:40:47,720 --> 01:40:50,760
MANAGED AS A SINGLE U24

2549
01:40:50,760 --> 01:40:52,120
COORDINATING SITE SUPPORTED BY

2550
01:40:52,120 --> 01:40:55,280
THE CELL CORE AT THE FREDERICK

2551
01:40:55,280 --> 01:40:56,680
NATIONAL LABORATORY FOR CANCER

2552
01:40:56,680 --> 01:40:56,960
RESEARCH.

2553
01:40:56,960 --> 01:41:01,920
AND THERE'S A WEBINAR FOR THAT

2554
01:41:01,920 --> 01:41:04,040
ON SEPTEMBER 7.

2555
01:41:04,040 --> 01:41:05,440
THE NEW DISCUSSION POINTS THAT

2556
01:41:05,440 --> 01:41:08,400
WERE BROUGHT UP ON OUR

2557
01:41:08,400 --> 01:41:11,880
SUBCOMMITTEE MEETING THIS

2558
01:41:11,880 --> 01:41:15,360
MORNING WERE A CONSIDERATION FOR

2559
01:41:15,360 --> 01:41:16,480
INCREASING OUR TRANSLATIONAL

2560
01:41:16,480 --> 01:41:18,120
RESEARCH TRAINING.

2561
01:41:18,120 --> 01:41:20,640
AND WE BEGAN BY INTRODUCING THE

2562
01:41:20,640 --> 01:41:21,040
NEED.

2563
01:41:21,040 --> 01:41:23,760
THIS WAS THROUGH THE FACT THAT

2564
01:41:23,760 --> 01:41:27,760
THERE'S A PROGRAM IN THE CANCER

2565
01:41:27,760 --> 01:41:28,520
CENTER THROUGH THE NCI

2566
01:41:28,520 --> 01:41:29,440
DEVELOPMENTAL THERAPEUTICS

2567
01:41:29,440 --> 01:41:32,480
PROGRAM WHERE YOU CAN GET

2568
01:41:32,480 --> 01:41:34,040
CONFIDENTIAL GUIDANCE.

2569
01:41:34,040 --> 01:41:34,920
IT'S BEEN OPERATIONAL FOR 3.5

2570
01:41:34,920 --> 01:41:35,360
YEARS.

2571
01:41:35,360 --> 01:41:39,520
SO FAR THERE'S BEEN A TOTAL OF

2572
01:41:39,520 --> 01:41:46,920
264 REQUESTS, 149  149

2573
01:41:46,920 --> 01:41:52,120
CONSULTATIONS ACROSS EVERY STATE

2574
01:41:52,120 --> 01:41:53,920
FROM PRE-CLINICAL TOXICOLOGY,

2575
01:41:53,920 --> 01:41:54,480
EFFICACY, PROOF-OF-CONCEPT

2576
01:41:54,480 --> 01:41:55,120
STUDIES, ET CETERA.

2577
01:41:55,120 --> 01:41:56,680
THERE'S CLEARLY A NEED BY PEOPLE

2578
01:41:56,680 --> 01:41:59,120
WORKING IN THE TRANSLATIONAL

2579
01:41:59,120 --> 01:41:59,640
CONTINUUM.

2580
01:41:59,640 --> 01:42:00,760
BUT I ALSO PROVIDED SOME

2581
01:42:00,760 --> 01:42:04,080
ANTIDOTES WITH THE FACT THAT

2582
01:42:04,080 --> 01:42:05,880
EVEN AT A MAJOR CANCER CENTER

2583
01:42:05,880 --> 01:42:08,200
THAT THERE'S MANY ISSUES THAT

2584
01:42:08,200 --> 01:42:10,240
ARISE IN THE TRANSLATIONAL

2585
01:42:10,240 --> 01:42:11,880
THERAPEUTIC PIPELINE.

2586
01:42:11,880 --> 01:42:15,200
AND THESE INCLUDE THINGS LIKE

2587
01:42:15,200 --> 01:42:17,080
INVESTIGATORS, EVEN SEASONED

2588
01:42:17,080 --> 01:42:17,720
INVESTIGATORS NOT UNDERSTANDING

2589
01:42:17,720 --> 01:42:21,680
THAT REQUIREMENT FOR FILING

2590
01:42:21,680 --> 01:42:24,120
PROVISIONAL PATENT PRIOR TO

2591
01:42:24,120 --> 01:42:26,040
PUBLIC DISCLOSURE, UNDERSTANDING

2592
01:42:26,040 --> 01:42:26,680
COMPETITIVE LANDSCAPE, CLINICAL

2593
01:42:26,680 --> 01:42:28,040
INDICATIONS, ET CETERA.

2594
01:42:28,040 --> 01:42:30,480
SO THIS MEETING THIS MORNING WAS

2595
01:42:30,480 --> 01:42:34,800
TO EXPLORE IDEAS AROUND

2596
01:42:34,800 --> 01:42:36,400
POTENTIALLY DEVELOPING EARLIER

2597
01:42:36,400 --> 01:42:42,040
STAGE THERAPEUTICS OR 

2598
01:42:42,040 --> 01:42:42,640
TRANSLATIONAL THERAPEUTICS,

2599
01:42:42,640 --> 01:42:43,240
EDUCATIONAL CURRICULUM.

2600
01:42:43,240 --> 01:42:44,880
BECAUSE THAT WAS THE

2601
01:42:44,880 --> 01:42:46,520
CONSIDERATION, WE HAD DR.

2602
01:42:46,520 --> 01:42:49,280
BUBBLER, DIRECTOR FOR THE CENTER

2603
01:42:49,280 --> 01:42:53,120
OF CANCER TRAINING, PROVIDED US

2604
01:42:53,120 --> 01:42:57,120
WITH INFORMATION WITH REGARDS TO

2605
01:42:57,120 --> 01:42:57,720
INTRAMURAL INTERAGENCY ONCOLOGY

2606
01:42:57,720 --> 01:42:58,920
TASK FORCE FELLOWSHIP.

2607
01:42:58,920 --> 01:43:00,680
THIS IS AN INTERESTING PROGRAM,

2608
01:43:00,680 --> 01:43:06,600
THE  IT'S A COMBINATION,

2609
01:43:06,600 --> 01:43:08,600
TWO-YEAR IN-HOUSE FELLOWSHIP TO

2610
01:43:08,600 --> 01:43:11,640
TRAIN SCIENTISTS IN RESEARCH AND

2611
01:43:11,640 --> 01:43:12,600
RESEARCH-RELATED REGULATORY

2612
01:43:12,600 --> 01:43:13,200
PROCESSES.

2613
01:43:13,200 --> 01:43:15,200
NOW, I'M GOING TO EMPHASIZE THIS

2614
01:43:15,200 --> 01:43:18,240
IS ON THE SORT OF RAPID

2615
01:43:18,240 --> 01:43:19,200
TRANSLATION INTO CLINICAL TRIALS

2616
01:43:19,200 --> 01:43:23,080
SORT OF PART OF THE CONTINUUM.

2617
01:43:23,080 --> 01:43:25,160
SINCE THE INITIATION, HE'S HAD A

2618
01:43:25,160 --> 01:43:26,880
TOTAL OF 70 GRADUATES TO DATE,

2619
01:43:26,880 --> 01:43:30,480
MANY OF THESE HAVE ACTUALLY

2620
01:43:30,480 --> 01:43:32,320
HAD -- WENT ON TO SERVE IN THE

2621
01:43:32,320 --> 01:43:40,280
FDA OR IN THE BIOMEDICAL

2622
01:43:40,280 --> 01:43:42,480
INDUSTRY. 

2623
01:43:42,480 --> 01:43:45,320
THERE'S A TOTAL OF 1572 ACTIVE

2624
01:43:45,320 --> 01:43:49,360
CANCER TRAINING AWARDS, IN

2625
01:43:49,360 --> 01:43:52,560
K12s, R25s, K08s, ET

2626
01:43:52,560 --> 01:43:53,640
CETERA.

2627
01:43:53,640 --> 01:43:55,520
AND OF THOSE, 166 SUPPORT

2628
01:43:55,520 --> 01:43:58,680
CLINICAL TRIALS. 

2629
01:43:58,680 --> 01:44:01,320
I WOULD LIKE TO NOTE THESE ARE

2630
01:44:01,320 --> 01:44:03,560
TRAINING GRANTS IN CANCER, THEY

2631
01:44:03,560 --> 01:44:05,360
DON'T NECESSARILY INFLUENCE OR

2632
01:44:05,360 --> 01:44:07,320
EDUCATE ON THAT TRANSLATIONAL

2633
01:44:07,320 --> 01:44:08,520
CONTINUUM, AT THE VERY EARLY

2634
01:44:08,520 --> 01:44:08,720
STAGE.

2635
01:44:08,720 --> 01:44:10,560
IN OTHER WORDS, HOW YOU VET

2636
01:44:10,560 --> 01:44:11,720
SOMETHING, HOW YOU PICK LEAD

2637
01:44:11,720 --> 01:44:13,280
TEST ARTICLES, ET CETERA.

2638
01:44:13,280 --> 01:44:15,160
SO, WE'VE GOT A VERY NICE SORT

2639
01:44:15,160 --> 01:44:19,200
OF PROGRAM AT THE NCI ON THE

2640
01:44:19,200 --> 01:44:20,480
RAPID TRANSLATION INTO CLINICAL

2641
01:44:20,480 --> 01:44:22,800
TRIALS STAGE OF THINGS.

2642
01:44:22,800 --> 01:44:25,040
HE ALSO BROUGHT UP THE METHODS

2643
01:44:25,040 --> 01:44:27,120
AND CLINICAL CANCER RESEARCH

2644
01:44:27,120 --> 01:44:27,400
WORKSHOP.

2645
01:44:27,400 --> 01:44:30,080
I WAS ONE OF THE FIRST OR

2646
01:44:30,080 --> 01:44:31,080
PROBABLY SECOND YEAR PARTICIPANT

2647
01:44:31,080 --> 01:44:32,600
WHEN IT WAS INITIATED A WHILE

2648
01:44:32,600 --> 01:44:32,880
AGO.

2649
01:44:32,880 --> 01:44:35,600
AND THIS IS REALLY WHERE AN

2650
01:44:35,600 --> 01:44:37,200
INVESTIGATOR BRINGS TO THIS

2651
01:44:37,200 --> 01:44:39,960
PARTICULAR WORKSHOP, IT'S A

2652
01:44:39,960 --> 01:44:41,320
WEEK-LONG COURSE, CLINICAL TRIAL

2653
01:44:41,320 --> 01:44:42,960
CONCEPT, AND THEN THEY HAVE

2654
01:44:42,960 --> 01:44:44,080
EXPERTS THAT COME IN AND HELP

2655
01:44:44,080 --> 01:44:45,960
WORK THROUGH THE CLINICAL TRIAL.

2656
01:44:45,960 --> 01:44:48,000
AGAIN, IT'S RIGHT AS YOU'RE

2657
01:44:48,000 --> 01:44:50,880
TRANSITIONING INTO CLINICAL

2658
01:44:50,880 --> 01:44:51,200
TRIAL.

2659
01:44:51,200 --> 01:44:53,200
SO, THE SUBCOMMITTEE, WE

2660
01:44:53,200 --> 01:44:55,200
DISCUSSED THE SPECIFIC

2661
01:44:55,200 --> 01:44:56,200
CHALLENGES ASSOCIATED WITH

2662
01:44:56,200 --> 01:44:57,840
TRANSLATIONAL RESEARCH.

2663
01:44:57,840 --> 01:44:59,480
AND THIS INVOLVED EDUCATION

2664
01:44:59,480 --> 01:45:01,720
AROUND THIS SORT OF ENDEAVOR.

2665
01:45:01,720 --> 01:45:03,880
FIRST OF ALL, THERE WAS A

2666
01:45:03,880 --> 01:45:05,040
DISCUSSION WITH REGARDS TO

2667
01:45:05,040 --> 01:45:07,080
INCREASING THE DIVERSITY OF THE

2668
01:45:07,080 --> 01:45:07,960
RESEARCH WORKFORCE WHICH

2669
01:45:07,960 --> 01:45:11,120
EVERYONE ON THIS BOARD AGREES IS

2670
01:45:11,120 --> 01:45:15,640
A KEY ISSUE.

2671
01:45:15,640 --> 01:45:16,320
THE MULTI-FACETED CHALLENGES

2672
01:45:16,320 --> 01:45:17,320
TRANSLATIONAL RESEARCH

2673
01:45:17,320 --> 01:45:18,120
INSTITUTIONAL SUPPORT FOR

2674
01:45:18,120 --> 01:45:21,040
INTELLECTUAL PROPERTY NEEDS FOR

2675
01:45:21,040 --> 01:45:22,240
THE INVESTIGATORS RESEARCHERS

2676
01:45:22,240 --> 01:45:23,960
NOT REALLY UNDERSTANDING THE

2677
01:45:23,960 --> 01:45:25,000
PROCESS, IN OTHER WORDS, YOU

2678
01:45:25,000 --> 01:45:27,920
KNOW, THE ACTUAL SORT OF PROCESS

2679
01:45:27,920 --> 01:45:29,160
YOU GO THROUGH WHEN PHARMA LOOKS

2680
01:45:29,160 --> 01:45:31,240
AL THESE KINDS OF THINGS.

2681
01:45:31,240 --> 01:45:32,200
AND THEN ADDITIONALLY THERE'S A

2682
01:45:32,200 --> 01:45:34,680
LOT OF LACK OF INSTITUTIONAL

2683
01:45:34,680 --> 01:45:36,440
INFRASTRUCTURE TO SUPPORT GOOD

2684
01:45:36,440 --> 01:45:37,600
LABORATORY PRACTICES, GOOD

2685
01:45:37,600 --> 01:45:38,480
MANUFACTURING PRACTICES, ET

2686
01:45:38,480 --> 01:45:38,920
CETERA.

2687
01:45:38,920 --> 01:45:40,840
AND THEN IT ALSO COMES DOWN TO

2688
01:45:40,840 --> 01:45:43,600
LACK OF EXPERTISE IN MULTIPLE

2689
01:45:43,600 --> 01:45:44,880
DOMAINS, THOSE INCLUDE BUSINESS

2690
01:45:44,880 --> 01:45:47,440
UNDERSTANDING, SORT OF WHETHER

2691
01:45:47,440 --> 01:45:50,320
YOU'RE GOING TO REAP YOUR RETURN

2692
01:45:50,320 --> 01:45:51,600
ON INVESTMENT WHEN DEVELOPING

2693
01:45:51,600 --> 01:45:53,320
SOMETHING, LEGAL ASPECTS OF

2694
01:45:53,320 --> 01:45:54,920
INTELLECTUAL PROPERTY, ET

2695
01:45:54,920 --> 01:45:55,920
CETERA.

2696
01:45:55,920 --> 01:45:56,680
AND BUSINESS ASPECTS.

2697
01:45:56,680 --> 01:45:58,000
SO, CERTAINLY THOSE KINDS OF

2698
01:45:58,000 --> 01:45:59,800
THINGS PLAY A ROLE IN PHARMA

2699
01:45:59,800 --> 01:46:02,400
WHEN THEY DEVELOP A DRUG, AND

2700
01:46:02,400 --> 01:46:04,640
THOSE ACADEMIC CENTERS ARE NOT

2701
01:46:04,640 --> 01:46:07,040
AWARE OF THESE KEY COMPONENTS AS

2702
01:46:07,040 --> 01:46:08,040
THEY ARE DEVELOPING THERAPEUTICS

2703
01:46:08,040 --> 01:46:12,320
AND I THINK WE HAVE A VARIETY OF

2704
01:46:12,320 --> 01:46:14,160
LOST INITIATIVES BECAUSE OF THE

2705
01:46:14,160 --> 01:46:15,360
LACK OF UNDERSTANDING.

2706
01:46:15,360 --> 01:46:18,440
SO, WE HAD A NUMBER OF KEY STEPS

2707
01:46:18,440 --> 01:46:19,240
THAT WERE ACTUALLY IDENTIFIED,

2708
01:46:19,240 --> 01:46:22,120
IF THIS IS SOMETHING THAT THE

2709
01:46:22,120 --> 01:46:24,800
GROUP WISHES TO OR IF THERE'S

2710
01:46:24,800 --> 01:46:26,880
SIGNIFICANT INTEREST IN

2711
01:46:26,880 --> 01:46:28,640
DEVELOPING THIS FURTHER.

2712
01:46:28,640 --> 01:46:30,200
THERE COULD BE DEVELOPMENT OF

2713
01:46:30,200 --> 01:46:31,800
NCI CURRICULUM THAT REALLY SORT

2714
01:46:31,800 --> 01:46:34,520
OF IS MORE FOCUSED ON THE EARLY

2715
01:46:34,520 --> 01:46:37,600
PARTS OF THE EDUCATIONAL

2716
01:46:37,600 --> 01:46:40,080
TRANSLATIONAL CONTINUUM.

2717
01:46:40,080 --> 01:46:42,160
WE COULD CERTAINLY ASSAY OR

2718
01:46:42,160 --> 01:46:43,040
ASSESS FROM CANCER CENTERS

2719
01:46:43,040 --> 01:46:44,920
DIRECTORS THE NEEDS OF THE

2720
01:46:44,920 --> 01:46:45,720
VARIOUS CANCER CENTERS, SPECIFIC

2721
01:46:45,720 --> 01:46:47,240
LIVE SORT OF THE AREAS THAT THEY

2722
01:46:47,240 --> 01:46:49,520
FEEL THEY ARE REALLY LACKING.

2723
01:46:49,520 --> 01:46:56,160
ONE OF THE ADVANTAGES OF HAVING

2724
01:46:56,160 --> 01:46:57,280
IT CENTRALIZED, REDUCES

2725
01:46:57,280 --> 01:46:58,240
DUPLICATION OF INFRASTRUCTURE,

2726
01:46:58,240 --> 01:46:59,680
COULD HARMONIZE, COULD BRING IN

2727
01:46:59,680 --> 01:47:01,400
THE LEADING EXPERTS IN THESE

2728
01:47:01,400 --> 01:47:02,800
DOMAINS TO REALLY SORT OF FOSTER

2729
01:47:02,800 --> 01:47:04,400
AND MAKE SURE THAT THE TRAINING

2730
01:47:04,400 --> 01:47:06,600
IS DONE BY THE BEST POSSIBLE

2731
01:47:06,600 --> 01:47:07,720
PERSON.

2732
01:47:07,720 --> 01:47:10,440
THIS COULD BE ARCHIVED, SO THAT

2733
01:47:10,440 --> 01:47:13,640
THESE TALKS OR THESE

2734
01:47:13,640 --> 01:47:15,200
INSTRUCTIONAL ACTIVITIES ARE

2735
01:47:15,200 --> 01:47:18,720
AVAILABLE TO THE TRAINEES.

2736
01:47:18,720 --> 01:47:21,680
WE COULD ALSO CONSIDER THIS

2737
01:47:21,680 --> 01:47:23,120
BEING SUPPORTED BY ARPA-H.

2738
01:47:23,120 --> 01:47:26,080
THIS WAS ACTUALLY A COMMENT MADE

2739
01:47:26,080 --> 01:47:28,600
IN DR. BARKER'S SUBSEQUENT

2740
01:47:28,600 --> 01:47:30,920
SESSION, BUT TRANSLATIONAL

2741
01:47:30,920 --> 01:47:32,320
RESEARCH IS NOT NATIONALLY

2742
01:47:32,320 --> 01:47:36,400
CONFINED TO CANCER, THERE'S

2743
01:47:36,400 --> 01:47:37,360
ALZHEIMER'S, NEUROSCIENCES, MANY

2744
01:47:37,360 --> 01:47:38,680
TYPES OF DISEASE PROCESSES THAT

2745
01:47:38,680 --> 01:47:40,880
WOULD BENEFIT FROM UNDERSTANDING

2746
01:47:40,880 --> 01:47:43,640
HOW TO REALLY OPTIMIZE THE

2747
01:47:43,640 --> 01:47:44,640
SUCCESS OF TRANSLATIONAL

2748
01:47:44,640 --> 01:47:44,880
RESEARCH.

2749
01:47:44,880 --> 01:47:47,640
AND SO I THINK THOSE WERE THE

2750
01:47:47,640 --> 01:47:49,320
KEY SORT OF DISCUSSION POINTS,

2751
01:47:49,320 --> 01:47:50,400
CERTAINLY IF ANYBODY ELSE WOULD

2752
01:47:50,400 --> 01:47:53,280
LIKE TO ADD THINGS THAT I'VE

2753
01:47:53,280 --> 01:47:57,560
MISSED I'M HAPPY TO HAVE YOU

2754
01:47:57,560 --> 01:48:02,320
VOLUNTEER.

2755
01:48:02,320 --> 01:48:03,480
>> GREAT, AMY.

2756
01:48:03,480 --> 01:48:10,120
LOOKS LIKE HOWARD HAS HIS HAND

2757
01:48:10,120 --> 01:48:10,640
UP.

2758
01:48:10,640 --> 01:48:12,480
>> SO, I JUST WANTED TO
SHARE

2759
01:48:12,480 --> 01:48:16,080
ANOTHER POINT THAT I'M NOT SURE

2760
01:48:16,080 --> 01:48:17,840
WAS EMPHASIZED.

2761
01:48:17,840 --> 01:48:20,400
AND THAT IS THE -- THERE HAVE

2762
01:48:20,400 --> 01:48:23,240
BEEN OTHER INITIATIVES TRYING

2763
01:48:23,240 --> 01:48:25,680
TO -- MY UNDERSTANDING, TO

2764
01:48:25,680 --> 01:48:29,480
ADVANCE THE SAME GOALS OF

2765
01:48:29,480 --> 01:48:31,560
HELPING TO OPTIMIZE

2766
01:48:31,560 --> 01:48:32,320
TRANSLATIONAL RESEARCH FROM

2767
01:48:32,320 --> 01:48:36,600
ACADEMIA INTO LET'S SAY BROADER

2768
01:48:36,600 --> 01:48:37,880
ACCESS OR COMMERCIALIZATION,

2769
01:48:37,880 --> 01:48:41,200
IMPACT ON PATIENT CARE.

2770
01:48:41,200 --> 01:48:42,880
AND THE LACK OF UNDERSTANDING

2771
01:48:42,880 --> 01:48:46,280
WAS ACTUALLY A SURVEY TOPIC IN

2772
01:48:46,280 --> 01:48:52,120
EUROPE AMONG THE EUROPEAN 

2773
01:48:52,120 --> 01:48:53,720
INVESTIGATORS WHO ACTUALLY

2774
01:48:53,720 --> 01:48:55,360
ANSWERED, NUMBER ONE, BEING THE

2775
01:48:55,360 --> 01:48:57,880
UPDATED -- THE NEED FOR TRAINING

2776
01:48:57,880 --> 01:48:59,680
AND UPDATED REGULATORY SCIENCES.

2777
01:48:59,680 --> 01:49:02,800
AND RESPONDING TO THAT, THE

2778
01:49:02,800 --> 01:49:04,560
REGULATORS STARTED SOMETHING

2779
01:49:04,560 --> 01:49:05,720
CALLED THE STARS INITIATIVE

2780
01:49:05,720 --> 01:49:10,240
WHICH IS NOW BEING IMPLEMENTED

2781
01:49:10,240 --> 01:49:11,000
GOING FORWARD.

2782
01:49:11,000 --> 01:49:13,960
AND I DON'T KNOW IF IT'S IN

2783
01:49:13,960 --> 01:49:17,600
RESPONSE BUT THE FDA, THE

2784
01:49:17,600 --> 01:49:19,240
ONCOLOGY CENTER OF EXCELLENCE

2785
01:49:19,240 --> 01:49:19,920
LAUNCHED PROJECT CATALYST,

2786
01:49:19,920 --> 01:49:20,400
SOMETHING SIMILAR.

2787
01:49:20,400 --> 01:49:21,880
I WANT TO BRING THOSE UP TO THE

2788
01:49:21,880 --> 01:49:27,240
GROUP BECAUSE I THINK THESE ARE

2789
01:49:27,240 --> 01:49:30,040
ALSO VERY IMPORTANT APPROACHES

2790
01:49:30,040 --> 01:49:32,080
THAT SHOULD BE, LET'S SAY,

2791
01:49:32,080 --> 01:49:33,880
FOLLOWED OR MAYBE LEARNED FROM

2792
01:49:33,880 --> 01:49:34,520
OR ENGAGED WITH.

2793
01:49:34,520 --> 01:49:36,920
I THINK NCI PEOPLE ARE ALREADY

2794
01:49:36,920 --> 01:49:37,920
ENGAGED IN PROJECT CATALYST

2795
01:49:37,920 --> 01:49:40,200
BECAUSE OF THEIR CLOSENESS WITH

2796
01:49:40,200 --> 01:49:44,280
THE FDA STAFF.

2797
01:49:44,280 --> 01:49:46,160
>> GREAT POINT, HOWARD, IN
TERMS

2798
01:49:46,160 --> 01:49:47,560
OF NOT REINVENTING THE WHEEL,

2799
01:49:47,560 --> 01:49:50,720
ARE THERE MODELS THAT WE COULD

2800
01:49:50,720 --> 01:49:55,680
LOOK AT THAT COULD BE TWEAKED.

2801
01:49:55,680 --> 01:49:56,320
AND INTERSECTIONS BETWEEN

2802
01:49:56,320 --> 01:49:57,120
PROGRAMS.

2803
01:49:57,120 --> 01:49:57,440
>> SURE.

2804
01:49:57,440 --> 01:50:00,560
I MEAN, I THINK ESPECIALLY FOR

2805
01:50:00,560 --> 01:50:01,520
UNDERSERVED RARE INDICATIONS,

2806
01:50:01,520 --> 01:50:03,480
PEDIATRICS, ET CETERA, WE HAVE

2807
01:50:03,480 --> 01:50:04,640
TO COLLABORATE.

2808
01:50:04,640 --> 01:50:05,040
>> ABSOLUTELY.

2809
01:50:05,040 --> 01:50:06,400
>> WITH THE EUROPEANS AND
OTHERS

2810
01:50:06,400 --> 01:50:07,880
THAT CAN DO QUALITY TRIALS AND

2811
01:50:07,880 --> 01:50:10,600
WANT TO COLLABORATE WITH US.

2812
01:50:10,600 --> 01:50:15,680
AND ON THE TOPICS LIKE

2813
01:50:15,680 --> 01:50:19,920
BIOMARKERS, THERE'S BEEN

2814
01:50:19,920 --> 01:50:20,760
DIVERGENCE, PROVIDING

2815
01:50:20,760 --> 01:50:23,320
OPPORTUNITY FOR HARMONIZATION, A

2816
01:50:23,320 --> 01:50:27,600
WIN-WIN, FOR THE SUPER RARE

2817
01:50:27,600 --> 01:50:28,160
INDICATIONS, HELPING BOTH

2818
01:50:28,160 --> 01:50:30,600
POPULATIONS ACROSS -- YOU KNOW,

2819
01:50:30,600 --> 01:50:32,120
ACROSS THE GLOBE.

2820
01:50:32,120 --> 01:50:33,040
>> GREAT.

2821
01:50:33,040 --> 01:50:34,000
THANKS, HOWARD.

2822
01:50:34,000 --> 01:50:36,400
ANY OTHER QUESTIONS OR COMMENTS

2823
01:50:36,400 --> 01:50:38,200
RELATED TO THE EXPERIMENTAL

2824
01:50:38,200 --> 01:50:40,320
THERAPEUTICS SUBCOMMITTEE?

2825
01:50:40,320 --> 01:50:43,040
>> I THINK IT WAS ONE
POINT I

2826
01:50:43,040 --> 01:50:44,960
NEGLECTED TO ADD IN, MY

2827
01:50:44,960 --> 01:50:45,880
APOLOGIES.

2828
01:50:45,880 --> 01:50:48,720
ONE OF THE THINGS THAT DR.

2829
01:50:48,720 --> 01:50:50,520
VOGLER BROUGHT UP, WAS THAT THE

2830
01:50:50,520 --> 01:50:52,960
CLINICAL TRIALS WAS PARTICULARLY

2831
01:50:52,960 --> 01:50:53,960
EFFECTIVE WHEN THE STUDENTS

2832
01:50:53,960 --> 01:50:56,080
BROUGHT IN SORT OF A REAL LIFE

2833
01:50:56,080 --> 01:50:56,400
EXAMPLE.

2834
01:50:56,400 --> 01:50:57,800
SO THE PROGRAM COULD, YOU KNOW,

2835
01:50:57,800 --> 01:51:01,640
IF WE'RE TALKING ABOUT EARLIER

2836
01:51:01,640 --> 01:51:02,840
IN THAT CONTINUUM PIPELINE, WE

2837
01:51:02,840 --> 01:51:04,560
COULD HAVE INVESTIGATORS

2838
01:51:04,560 --> 01:51:06,040
INVOLVED THAT LET'S SAY THE

2839
01:51:06,040 --> 01:51:07,880
TARGET THEY WANT TO DEVELOP AND

2840
01:51:07,880 --> 01:51:09,520
IN OTHER WORDS THEY HAVE, YOU

2841
01:51:09,520 --> 01:51:11,280
KNOW, A REAL EXAMPLE THEY WANT

2842
01:51:11,280 --> 01:51:12,520
TO IMPLEMENT THROUGH THE

2843
01:51:12,520 --> 01:51:14,080
PROGRAM, HE THOUGHT THAT WOULD

2844
01:51:14,080 --> 01:51:15,520
BE MUCH MORE EFFECTIVE STRATEGY

2845
01:51:15,520 --> 01:51:17,840
AS OPPOSED TO JUST A GENERAL

2846
01:51:17,840 --> 01:51:20,360
CURRICULUM JUST STRAIGHT, YOU

2847
01:51:20,360 --> 01:51:22,560
KNOW, FORWARD, WITH NO OTHER

2848
01:51:22,560 --> 01:51:26,160
WORKING EXAMPLE. 

2849
01:51:26,160 --> 01:51:32,720
>> YEAH, KIND OF --
THERE'S

2850
01:51:32,720 --> 01:51:34,240
DIDACTIC AND PRACTICAL.

2851
01:51:34,240 --> 01:51:35,000
THAT'S GREAT.

2852
01:51:35,000 --> 01:51:37,200
CAN YOU LOWER YOUR HAND IF YOU

2853
01:51:37,200 --> 01:51:39,800
DON'T HAVE ANOTHER QUESTION SO

2854
01:51:39,800 --> 01:51:42,360
WE CAN -- OKAY.

2855
01:51:42,360 --> 01:51:44,320
IF THERE ARE NO OTHER QUESTIONS

2856
01:51:44,320 --> 01:51:47,360
OR COMMENTS PERTAINING TO

2857
01:51:47,360 --> 01:51:48,880
EXPERIMENTAL THERAPEUTICS, THAT

2858
01:51:48,880 --> 01:51:50,120
SUBCOMMITTEE, THE SECOND

2859
01:51:50,120 --> 01:51:50,960
SUBCOMMITTEE REPORT WILL BE

2860
01:51:50,960 --> 01:51:55,520
GIVEN BY DR. ANN BARKER WHO 

2861
01:51:55,520 --> 01:51:56,680
CHAIRS SUBCOMMITTEE ON PLANNING

2862
01:51:56,680 --> 01:51:57,360
AND BUDGET.

2863
01:51:57,360 --> 01:51:57,560
ANN?

2864
01:51:57,560 --> 01:52:00,840
>> ALL RIGHT, THANK YOU. 

2865
01:52:00,840 --> 01:52:02,000
THANKS TO THE COMMITTEE TODAY.

2866
01:52:02,000 --> 01:52:04,920
WE HAD A GREAT DISCUSSION.

2867
01:52:04,920 --> 01:52:07,400
AND TO OUR EXECUTIVE SECRETARY,

2868
01:52:07,400 --> 01:52:09,280
PATRICK MCGAREY, WHO ALWAYS DOES

2869
01:52:09,280 --> 01:52:11,160
A GREAT JOB FOR BRINGING US A

2870
01:52:11,160 --> 01:52:13,640
LOT OF DETAILS ABOUT PLANNING

2871
01:52:13,640 --> 01:52:17,120
AND BUDGET, WHICH IS COMPLEX.

2872
01:52:17,120 --> 01:52:21,560
SO, WE STARTED OUR MEETING WITH

2873
01:52:21,560 --> 01:52:25,480
SOMETHING IS CLOSE TO MY HEART,

2874
01:52:25,480 --> 01:52:28,320
WE'RE AT A POINT IN CANCER

2875
01:52:28,320 --> 01:52:28,920
RESEARCH SEEING ENORMOUS

2876
01:52:28,920 --> 01:52:31,640
INTEREST ACROSS LOTS OF FIELDS

2877
01:52:31,640 --> 01:52:33,680
OF RESEARCH THAT ACTUALLY

2878
01:52:33,680 --> 01:52:34,960
MAINLINE CANCER RESEARCH WITH

2879
01:52:34,960 --> 01:52:35,960
THINGS THAT REPRESENTATIVE

2880
01:52:35,960 --> 01:52:38,400
CONVERGENCE WITH CANCER WHICH WE

2881
01:52:38,400 --> 01:52:41,040
NEED, AND I THINK MAYBE DUE TO

2882
01:52:41,040 --> 01:52:43,760
THE FIRST MOONSHOT WE HAVE AN

2883
01:52:43,760 --> 01:52:44,840
INFLUX OF APPLICATIONS, STARTING

2884
01:52:44,840 --> 01:52:48,760
ALL THE WAY BACK IN 2013, AND

2885
01:52:48,760 --> 01:52:52,160
50% INCREASE WHICH IS UNHEARD

2886
01:52:52,160 --> 01:52:53,240
OF.

2887
01:52:53,240 --> 01:52:53,880
AND THERE'S NOT ANOTHER MEMBER

2888
01:52:53,880 --> 01:52:55,360
OF THE NIH THAT HAS EVEN

2889
01:52:55,360 --> 01:53:00,320
ANYTHING CLOSE TO THAT KIND OF

2890
01:53:00,320 --> 01:53:00,880
SUBMISSION.

2891
01:53:00,880 --> 01:53:02,560
WE TALKED ABOUT THAT IN TERMS OF

2892
01:53:02,560 --> 01:53:03,960
ITS IMPACT ON EVERYTHING,

2893
01:53:03,960 --> 01:53:05,400
ESSENTIALLY, YOU KNOW, HOW DO WE

2894
01:53:05,400 --> 01:53:06,920
KEEP THE PAYLINES WHERE WE WANT

2895
01:53:06,920 --> 01:53:11,200
THEM TO BE, WHAT ARE OUR SUCCESS

2896
01:53:11,200 --> 01:53:11,520
RATES.

2897
01:53:11,520 --> 01:53:12,800
THE THING CONCERNING HERE IS

2898
01:53:12,800 --> 01:53:14,600
THAT THIS IS AN INFLECTION POINT

2899
01:53:14,600 --> 01:53:16,680
I THINK WHERE SO MUCH IN CANCER

2900
01:53:16,680 --> 01:53:18,840
RIGHT NOW IS SO EXCITING, SO

2901
01:53:18,840 --> 01:53:20,840
MANY PEOPLE, ESPECIALLY YOUNG

2902
01:53:20,840 --> 01:53:23,040
PEOPLE, AND WE DON'T WANT TO

2903
01:53:23,040 --> 01:53:23,680
DISCOURAGE THEM.

2904
01:53:23,680 --> 01:53:24,760
NIH DOES EVERYTHING THEY

2905
01:53:24,760 --> 01:53:27,120
POSSIBLY CAN TO MAKE SURE THAT

2906
01:53:27,120 --> 01:53:29,200
THOSE COMPETITIVE GRANTS ARE

2907
01:53:29,200 --> 01:53:29,440
FUNDED.

2908
01:53:29,440 --> 01:53:34,320
SO, WE MOVED ON FROM THERE TO

2909
01:53:34,320 --> 01:53:38,720
TALK ABOUT 2022, WITH PATRICK'S

2910
01:53:38,720 --> 01:53:39,200
GUIDANCE.

2911
01:53:39,200 --> 01:53:44,160
ESSENTIALLY, IT'S PRETTY MUCH IN

2912
01:53:44,160 --> 01:53:45,600
THE BOOKS WITH ANOTHER MONTH TO

2913
01:53:45,600 --> 01:53:47,520
GO BUT LOOKS AS THOUGH OUR

2914
01:53:47,520 --> 01:53:54,240
APPROPRIATION IS GOING TO BE

2915
01:53:54,240 --> 01:53:56,760
6.9 MILLION, $6.7 MILLION IN THE

2916
01:53:56,760 --> 01:53:59,680
BASE, THINGS THAT ADD INTO THAT

2917
01:53:59,680 --> 01:54:01,040
NUMBER OF 6.9 THAT MAY BE

2918
01:54:01,040 --> 01:54:02,760
FUNDABLE, AND THEY MAY NOT BE

2919
01:54:02,760 --> 01:54:04,440
WITH US FOREVER AND ONE OF THOSE

2920
01:54:04,440 --> 01:54:07,720
ACTUALLY IS THE CANCER MOONSHOT

2921
01:54:07,720 --> 01:54:09,320
MONEY WHICH ACTUALLY THE LAST

2922
01:54:09,320 --> 01:54:11,680
YEAR IS NEXT YEAR, SO WE ALL

2923
01:54:11,680 --> 01:54:12,680
HAVE TO THINK ABOUT THAT.

2924
01:54:12,680 --> 01:54:15,480
LOTS OF PEOPLE ARE THINKING

2925
01:54:15,480 --> 01:54:16,160
ABOUT IT.

2926
01:54:16,160 --> 01:54:18,480
SO FINAL YEAR OF THE MOONSHOT

2927
01:54:18,480 --> 01:54:20,880
AND WE'RE YET TO SEE HOW

2928
01:54:20,880 --> 01:54:21,960
APPROPRIATIONS FOR THE MOONSHOT

2929
01:54:21,960 --> 01:54:25,600
IS GOING TO PLAY OUT IN MOONSHOT

2930
01:54:25,600 --> 01:54:26,240
2.0.

2931
01:54:26,240 --> 01:54:28,880
IT'S IN PROCESS.

2932
01:54:28,880 --> 01:54:30,680
SO, THE METRICS WILL BE DONE.

2933
01:54:30,680 --> 01:54:34,160
I SUSPECT CLOSE TO THE END OF

2934
01:54:34,160 --> 01:54:35,640
THE YEAR FOR 2022, BUT IT LOOKS

2935
01:54:35,640 --> 01:54:38,880
AS THOUGH WE WERE ABLE TO

2936
01:54:38,880 --> 01:54:41,280
SUSTAIN OUR PLAN FOR FUNDING AT

2937
01:54:41,280 --> 01:54:43,280
THE PAY LINES WE HAD THE

2938
01:54:43,280 --> 01:54:43,880
PREVIOUS YEARS.

2939
01:54:43,880 --> 01:54:46,560
AND I THINK THAT'S GREAT NEWS.

2940
01:54:46,560 --> 01:54:48,360
WE ACTUALLY HOPE THAT WE CAN

2941
01:54:48,360 --> 01:54:52,800
KEEP THAT UP AND WE GET TO 15%

2942
01:54:52,800 --> 01:54:55,040
BY 2025.

2943
01:54:55,040 --> 01:54:56,080
THAT'S OUR GOAL.

2944
01:54:56,080 --> 01:54:57,520
THAT'S GOING TO BE HARD.

2945
01:54:57,520 --> 01:55:03,000
I THINK EVERYBODY NEEDS TO 

2946
01:55:03,000 --> 01:55:04,320
UNDERSTAND EVERYTHING AFFECTS

2947
01:55:04,320 --> 01:55:04,520
THIS.

2948
01:55:04,520 --> 01:55:05,160
CERTAINLY INFLATION THAT WE

2949
01:55:05,160 --> 01:55:08,760
DIDN'T TALK ABOUT TODAY IS A BIG

2950
01:55:08,760 --> 01:55:10,320
DEAL.

2951
01:55:10,320 --> 01:55:13,800
RAISING PAYLINES AS PATRICK

2952
01:55:13,800 --> 01:55:16,000
POINTED OUT IS A HEAVY LIFT.

2953
01:55:16,000 --> 01:55:20,840
JUST FROM LAST YEAR TO THIS

2954
01:55:20,840 --> 01:55:22,560
YEAR, THAT'S A $39 MILLION PACK

2955
01:55:22,560 --> 01:55:24,520
TO CAPTURE THAT ON HIS BACK,

2956
01:55:24,520 --> 01:55:26,840
GOING UP THE MOUNTAIN.

2957
01:55:26,840 --> 01:55:27,640
THAT'S ADDITIONAL $39 MILLION

2958
01:55:27,640 --> 01:55:29,840
THAT WE HAVE TO CARRY.

2959
01:55:29,840 --> 01:55:32,400
AND SO EVERY YEAR THAT WE WANT

2960
01:55:32,400 --> 01:55:34,400
THE PAYLINE TO GO UP WE HAVE TO

2961
01:55:34,400 --> 01:55:36,240
LOOK AT HOW MUCH ARE WE

2962
01:55:36,240 --> 01:55:39,080
COMMITTING IN THE OUT YEARS, SO

2963
01:55:39,080 --> 01:55:40,360
THAT'S ANOTHER THING, YOU THINK

2964
01:55:40,360 --> 01:55:43,720
OUR GRANTS ARE FOUR AND FIVE

2965
01:55:43,720 --> 01:55:45,520
YEARS AND INCREASINGLY SEVEN, AS

2966
01:55:45,520 --> 01:55:47,560
PEOPLE CONVERT TO R 37s.

2967
01:55:47,560 --> 01:55:50,160
SO, A LOT TO THINK ABOUT HERE IN

2968
01:55:50,160 --> 01:55:52,600
TERMS OF OUR NEW DIRECTOR OF THE

2969
01:55:52,600 --> 01:56:03,080
NCI COMING IN, AND HOW WE'RE

2970
01:56:09,600 --> 01:56:16,360
GOING TO OPTIMIZE PAYLINES.

2971
01:56:16,360 --> 01:56:19,520
2023 IS STILL UP IN THE AIR,

2972
01:56:19,520 --> 01:56:21,600
HOPEFULLY THE SENATE AND HOUSE

2973
01:56:21,600 --> 01:56:22,320
COMING TOGETHER AFTER THE

2974
01:56:22,320 --> 01:56:23,600
ELECTION, NOT BEFORE THE

2975
01:56:23,600 --> 01:56:24,160
ELECTION.

2976
01:56:24,160 --> 01:56:26,680
EVERYBODY IS GOING HOME SHORTLY

2977
01:56:26,680 --> 01:56:30,120
TO CAMPAIGN.

2978
01:56:30,120 --> 01:56:32,240
BUT CURRENTLY, IT'S LOOKING

2979
01:56:32,240 --> 01:56:32,440
GOOD.

2980
01:56:32,440 --> 01:56:34,040
I MEAN, I THINK IT WAS PROPOSED

2981
01:56:34,040 --> 01:56:35,560
IN THE SENATE, AN WHAT'S

2982
01:56:35,560 --> 01:56:37,560
PROPOSED IN THE HOUSE, ARE NOT

2983
01:56:37,560 --> 01:56:40,920
THE SAME THING BUT THEY ARE

2984
01:56:40,920 --> 01:56:41,120
CLOSE.

2985
01:56:41,120 --> 01:56:45,320
AND SO THEY ARE ALSO LOOKING AT

2986
01:56:45,320 --> 01:56:45,560
ARPA-H.

2987
01:56:45,560 --> 01:56:48,680
AND I COME BACK TO ARPA-H IN

2988
01:56:48,680 --> 01:56:52,400
JUST A MINUTE, BUT OUR BUDGET

2989
01:56:52,400 --> 01:56:55,240
ACTUALLY CURRENTLY IN THE SENATE

2990
01:56:55,240 --> 01:57:00,160
IS I THINK 4.2% IN THE HOUSE AND

2991
01:57:00,160 --> 01:57:01,360
6.7% IN THE HOUSE, 4.2% IN THE

2992
01:57:01,360 --> 01:57:02,640
SENATE, AND IT WILL BE SOME

2993
01:57:02,640 --> 01:57:04,360
WHETHER IN THE MIDDLE.

2994
01:57:04,360 --> 01:57:06,400
WE COULD GUESS, BUT THAT'S

2995
01:57:06,400 --> 01:57:07,320
ACTUALLY PRETTY GOOD.

2996
01:57:07,320 --> 01:57:10,200
I THINK THE ISSUE WITH US IS,

2997
01:57:10,200 --> 01:57:12,720
YOU KNOW, LOSING MOONSHOT MONEY

2998
01:57:12,720 --> 01:57:14,640
AND AFTER NEXT YEAR.

2999
01:57:14,640 --> 01:57:17,520
ARPA-H CONTINUES TO BE A REALLY

3000
01:57:17,520 --> 01:57:20,120
INTERESTING FOOTBALL THAT KEEPS

3001
01:57:20,120 --> 01:57:21,080
GETTING TOSSED AROUND.

3002
01:57:21,080 --> 01:57:23,960
AND IT HASN'T GOT AN WHOLE LOT

3003
01:57:23,960 --> 01:57:24,720
BETTER.

3004
01:57:24,720 --> 01:57:27,280
SO, THERE ARE TWO PROPOSALS FOR

3005
01:57:27,280 --> 01:57:33,160
FUNDING THIS IN TERMS OF 2.75

3006
01:57:33,160 --> 01:57:37,000
AND A MILLION TO ADD, IN TWO

3007
01:57:37,000 --> 01:57:38,880
DIFFERENT TIMES.

3008
01:57:38,880 --> 01:57:42,560
THE HOUSE AND SENATE STILL HAVE

3009
01:57:42,560 --> 01:57:43,840
HAVEN'T AGREED ON WHAT THE LEVEL

3010
01:57:43,840 --> 01:57:45,240
OF FUNDING FOR ARPA-H SHOULD BE.

3011
01:57:45,240 --> 01:57:47,000
AND I AM NOT SURE HOW THEY ARE

3012
01:57:47,000 --> 01:57:48,240
GOING TO COME TO THAT.

3013
01:57:48,240 --> 01:57:49,000
THAT'S AN INTERESTING QUESTION

3014
01:57:49,000 --> 01:57:51,080
IN TERMS OF AUTHORIZING THAT AND

3015
01:57:51,080 --> 01:57:52,040
GETTING IT PAID.

3016
01:57:52,040 --> 01:57:56,080
BUT WE ALSO DON'T HAVE A

3017
01:57:56,080 --> 01:57:56,320
DIRECTOR.

3018
01:57:56,320 --> 01:57:57,840
AND WE ALSO DON'T HAVE AN

3019
01:57:57,840 --> 01:57:59,000
AGREEMENT ON WHERE ARPA-H IS

3020
01:57:59,000 --> 01:57:59,800
GOING TO BE.

3021
01:57:59,800 --> 01:58:01,880
WE THOUGHT WE HAD AN AGREEMENT

3022
01:58:01,880 --> 01:58:02,920
BECAUSE WE THOUGHT IT WAS GOING

3023
01:58:02,920 --> 01:58:07,960
TO BE AT NIH FOR A WHILE BUT IT

3024
01:58:07,960 --> 01:58:09,320
LOOKS LIKE CONGRESSMEN ESHOO

3025
01:58:09,320 --> 01:58:10,960
FROM CALIFORNIA AND HER

3026
01:58:10,960 --> 01:58:13,120
COLLEAGUES SAY NO, SO THAT'S AN

3027
01:58:13,120 --> 01:58:14,280
ONGOING CONVERSATION.

3028
01:58:14,280 --> 01:58:15,800
I THINK THIS IS IMPORTANT

3029
01:58:15,800 --> 01:58:16,680
LEGISLATION FOR NCI.

3030
01:58:16,680 --> 01:58:19,960
I THINK A LOT OF THE THINGS WE

3031
01:58:19,960 --> 01:58:21,440
TALKED ABOUT IN EXPERIMENTAL

3032
01:58:21,440 --> 01:58:22,040
THERAPEUTICS FOR EXAMPLE COULD

3033
01:58:22,040 --> 01:58:25,520
BE PAID OUT OF THAT KIND OF

3034
01:58:25,520 --> 01:58:26,080
FUNDING.

3035
01:58:26,080 --> 01:58:33,080
WE TALKED ABOUT THE MOONSHOT,

3036
01:58:33,080 --> 01:58:35,920
IT'S THE REALLY ENERGIZED

3037
01:58:35,920 --> 01:58:39,360
CATALYZED MOONSHOT 2.0, NCI HAS

3038
01:58:39,360 --> 01:58:43,520
SUBMITTED VERY GOOD IDEAS FOR

3039
01:58:43,520 --> 01:58:46,400
THAT AND ESPECIALLY MULTIPLE

3040
01:58:46,400 --> 01:58:48,200
CANCER TESTING, REALLY UPGRADING

3041
01:58:48,200 --> 01:58:51,200
AND RELAUNCHING SORT OF NEXT GEN

3042
01:58:51,200 --> 01:58:52,040
CLINICAL TRIALS.

3043
01:58:52,040 --> 01:58:54,000
BUT DOUG IN OUR DISCUSSION MADE

3044
01:58:54,000 --> 01:58:59,520
THE POINT THAT REALLY IF YOU

3045
01:58:59,520 --> 01:59:01,680
LISTEN TO PRESIDENT BIDEN

3046
01:59:01,680 --> 01:59:03,280
ESTABLISHING CANCER CABINET,

3047
01:59:03,280 --> 01:59:04,400
SETTING UP THE MOONSHOT, HE'S

3048
01:59:04,400 --> 01:59:06,360
REALLY INTERESTED IN DOING MORE

3049
01:59:06,360 --> 01:59:07,800
ABOUT CARE DELIVERY.

3050
01:59:07,800 --> 01:59:11,360
AND CHANGING THE LIVES OF

3051
01:59:11,360 --> 01:59:11,600
PATIENTS.

3052
01:59:11,600 --> 01:59:13,560
MOONSHOT 1.0 WAS ESSENTIALLY

3053
01:59:13,560 --> 01:59:15,320
ABOUT LET'S ACCELERATE RESEARCH.

3054
01:59:15,320 --> 01:59:16,560
THIS IS ABOUT GETTING WHAT WE

3055
01:59:16,560 --> 01:59:20,040
KNOW TO PATIENTS AND DOING IT

3056
01:59:20,040 --> 01:59:21,360
FASTER, BETTER, AND I THINK NCI

3057
01:59:21,360 --> 01:59:27,920
HAS SOME VERY GOOD IDEAS IN THAT

3058
01:59:27,920 --> 01:59:28,440
REGARD.

3059
01:59:28,440 --> 01:59:32,520
WE DID AS A GROUP COMMENDED DOUG

3060
01:59:32,520 --> 01:59:35,400
ON HIS PUBLIC SERVICE, BEYOND

3061
01:59:35,400 --> 01:59:37,680
THE VEIL IN TERMS OF HOW MUCH

3062
01:59:37,680 --> 01:59:39,040
HE'S DONE ESPECIALLY IN THESE

3063
01:59:39,040 --> 01:59:41,640
DIFFICULT  BUDGET TIMES.

3064
01:59:41,640 --> 01:59:43,200
I DON'T THINK THAT'S GOING TO

3065
01:59:43,200 --> 01:59:45,360
CHANGE GOING FORWARD FOR OUR NEW

3066
01:59:45,360 --> 01:59:46,200
DIRECTOR.

3067
01:59:46,200 --> 01:59:47,520
YOU KNOW, I HONESTLY THINK --

3068
01:59:47,520 --> 01:59:51,440
ONE OTHER CONVERSATION WE HAD,

3069
01:59:51,440 --> 01:59:53,200
BECAUSE I SEE DR. SHRIVER ON THE

3070
01:59:53,200 --> 01:59:55,200
PANEL TODAY, WE PACT ABOUT THE

3071
01:59:55,200 --> 01:59:57,760
PACT ACT AS AN EXAMPLE OF WHERE

3072
01:59:57,760 --> 02:00:00,520
NCI CAN PARTNER WITH ANOTHER

3073
02:00:00,520 --> 02:00:00,840
AGENCY.

3074
02:00:00,840 --> 02:00:02,800
FOR EXAMPLE, PACT ACT AS MANY OF

3075
02:00:02,800 --> 02:00:06,840
YOU HEARD REALLY GOT A LOT OF

3076
02:00:06,840 --> 02:00:09,520
PRESS TO LOOK AT CARCINOGENESIS

3077
02:00:09,520 --> 02:00:14,720
AND OTHER EFFECTS IN SERVICE

3078
02:00:14,720 --> 02:00:16,640
PEOPLE WHO SERVED IN VARIOUS

3079
02:00:16,640 --> 02:00:17,760
FIELDS OF COMBAT.

3080
02:00:17,760 --> 02:00:19,560
IT'S AN INTERESTING APPROACH TO

3081
02:00:19,560 --> 02:00:20,560
MAKING LIVES BETTER FOR PEOPLE

3082
02:00:20,560 --> 02:00:22,760
ESPECIALLY IN THE MILITARY WITH

3083
02:00:22,760 --> 02:00:23,000
CANCER.

3084
02:00:23,000 --> 02:00:24,480
THIS IS THE PLACE WHERE IT'S

3085
02:00:24,480 --> 02:00:26,320
GOING TO BE ABOUT

3086
02:00:26,320 --> 02:00:27,400
CARCINOGENESIS, SO VERY COMPLEX

3087
02:00:27,400 --> 02:00:29,480
MIXTURES, SO IT'S A GOOD PLACE,

3088
02:00:29,480 --> 02:00:31,040
I KNOW NCI IS THINKING HOW THEY

3089
02:00:31,040 --> 02:00:32,640
MIGHT PARTNER ON THAT.

3090
02:00:32,640 --> 02:00:35,040
AND THERE ARE OTHER PIECES OF

3091
02:00:35,040 --> 02:00:37,400
LEGISLATION THAT ARE SIMILAR IN

3092
02:00:37,400 --> 02:00:39,120
TERMS OF OFFERING NCI

3093
02:00:39,120 --> 02:00:40,320
PARTNERSHIPS THAT I'M SURE WE'LL

3094
02:00:40,320 --> 02:00:44,560
FOLLOW UP ON.

3095
02:00:44,560 --> 02:00:47,960
SO, WE TALKED ABOUT A LOT IN

3096
02:00:47,960 --> 02:00:49,960
THIS PLANNING AND BUDGET MEETING

3097
02:00:49,960 --> 02:00:53,240
BUT ONE THING I'VE BEEN TALKING

3098
02:00:53,240 --> 02:00:54,800
ABOUT QUITE A LOT, MAYBE TOO

3099
02:00:54,800 --> 02:00:57,080
MUCH, BUT I THINK MULTI-CANCER

3100
02:00:57,080 --> 02:00:59,480
TESTING IS SOMETHING THAT WE

3101
02:00:59,480 --> 02:01:02,200
CAN'T IGNORE AS I SAID EARLIER.

3102
02:01:02,200 --> 02:01:04,240
IT'S A PARADIGM SHIFT, IF YOU

3103
02:01:04,240 --> 02:01:05,840
CAN DETECT CANCER VERY, VERY

3104
02:01:05,840 --> 02:01:07,120
EARLY THAT SOUNDS GREAT, BUT

3105
02:01:07,120 --> 02:01:09,240
THERE'S A LOT OF THINGS THAT

3106
02:01:09,240 --> 02:01:10,520
FLOW FROM THAT.

3107
02:01:10,520 --> 02:01:13,560
AND I THINK I SUGGESTED AT THE

3108
02:01:13,560 --> 02:01:15,680
LAST NCAB MEETING THIS MAY BE AN

3109
02:01:15,680 --> 02:01:20,520
AREA WHERE THE NCAB SHOULD

3110
02:01:20,520 --> 02:01:22,280
REALLY LOOK AT WE'RE DOING

3111
02:01:22,280 --> 02:01:24,880
CLINICAL TRIALS, THE ONLY GROUP

3112
02:01:24,880 --> 02:01:26,000
DOING CLINICAL TRIALS WITH

3113
02:01:26,000 --> 02:01:27,360
SURVIVAL ENDPOINTS IN THE

3114
02:01:27,360 --> 02:01:28,120
MULTI-CANCER DETECTION SPACE.

3115
02:01:28,120 --> 02:01:29,560
THAT'S GOING TO BE CRITICALLY

3116
02:01:29,560 --> 02:01:33,400
IMPORTANT BUT THERE ARE LOTS OF 

3117
02:01:33,400 --> 02:01:35,720
OTHER PIECES OF THIS THAT WILL

3118
02:01:35,720 --> 02:01:37,760
INVOLVE THE NCI SO ANYTHING THE

3119
02:01:37,760 --> 02:01:39,640
NCAB CAN DO TO OFFER ADVICE

3120
02:01:39,640 --> 02:01:41,640
WOULD BE WORTH THINKING ABOUT,

3121
02:01:41,640 --> 02:01:47,880
MAYBE A STUDY FROM THE NCAB. 

3122
02:01:47,880 --> 02:01:49,920
WE HAD SOME QUESTIONS, PATRICK

3123
02:01:49,920 --> 02:01:52,040
ACTUALLY SHARED LINKS, IF YOU'RE

3124
02:01:52,040 --> 02:01:52,640
INTERESTED WE'VE HAD QUESTIONS

3125
02:01:52,640 --> 02:01:54,360
ON, YOU KNOW, HOW DO I FIND OUT

3126
02:01:54,360 --> 02:01:56,200
HOW MUCH FUNDING IS GOING INTO

3127
02:01:56,200 --> 02:01:57,520
MY CANCER.

3128
02:01:57,520 --> 02:02:00,680
THIS IS AN ADVOCATE QUESTION,

3129
02:02:00,680 --> 02:02:00,960
ACTUALLY.

3130
02:02:00,960 --> 02:02:02,360
AND THERE ARE -- I DON'T HAVE

3131
02:02:02,360 --> 02:02:03,680
THEM EASILY TO SHOW YOU HERE BUT

3132
02:02:03,680 --> 02:02:05,080
THERE ARE PLACES YOU CAN GO ON

3133
02:02:05,080 --> 02:02:08,280
THE WEBSITE AND LOOK THAT UP.

3134
02:02:08,280 --> 02:02:10,360
AND SO ANYWAY, WE ADJOURNED.

3135
02:02:10,360 --> 02:02:13,600
IT WAS A VERY ACTIVE

3136
02:02:13,600 --> 02:02:17,880
CONVERSATION WITH GREAT HOPES

3137
02:02:17,880 --> 02:02:20,400
FOR 2023 AND SPECULATION ABOUT

3138
02:02:20,400 --> 02:02:20,800
2024.

3139
02:02:20,800 --> 02:02:22,480
THERE'S AN ELECTION COMING UP,

3140
02:02:22,480 --> 02:02:25,600
AND NOBODY KNOWS WHERE IT MAY

3141
02:02:25,600 --> 02:02:29,280
ALL END UP, BUT I THINK NCI IS

3142
02:02:29,280 --> 02:02:30,560
WELL POSITIONED CERTAINLY WITH

3143
02:02:30,560 --> 02:02:31,360
THE CONGRESS.

3144
02:02:31,360 --> 02:02:34,000
THEY THINK A LOT OF OUR

3145
02:02:34,000 --> 02:02:35,720
INSTITUTE AND CERTAINLY THE NIH

3146
02:02:35,720 --> 02:02:39,920
AND WE HAVE A LOT OF FRIENDS.

3147
02:02:39,920 --> 02:02:40,320
SO I'M OPTIMISTIC.

3148
02:02:40,320 --> 02:02:41,200
THANK YOU, MR. CHAIRMAN.

3149
02:02:41,200 --> 02:02:44,080
THAT'S MY REPORT.

3150
02:02:44,080 --> 02:02:50,320
>> THANK YOU, DR. BARKER.

3151
02:02:50,320 --> 02:02:54,240
ANY QUESTIONS OR COMMENTS?

3152
02:02:54,240 --> 02:02:58,800
 

3153
02:02:58,800 --> 02:03:01,840
RELATIVE TO BUDGET AND PLANNING?

3154
02:03:01,840 --> 02:03:03,960
FOR ME IT'S THE PLANNING PART,

3155
02:03:03,960 --> 02:03:05,640
HOW FAR OUT YOU CAN BEGIN TO

3156
02:03:05,640 --> 02:03:08,440
PLAN OR THINK ABOUT THINGS,

3157
02:03:08,440 --> 02:03:09,920
AGAIN CONSIDERING MOON SHOOT,

3158
02:03:09,920 --> 02:03:11,520
YOU KNOW, HOW DOES THAT FUNDING

3159
02:03:11,520 --> 02:03:12,560
OCCURRED?

3160
02:03:12,560 --> 02:03:14,640
WE KNOW HOW IT OCCURRED

3161
02:03:14,640 --> 02:03:15,760
PREVIOUSLY THROUGH 21ST CENTURY

3162
02:03:15,760 --> 02:03:18,600
CURES ACT, AND WILL IT BE A

3163
02:03:18,600 --> 02:03:19,720
SIMILAR MODEL GOING FORWARD?

3164
02:03:19,720 --> 02:03:21,840
WILL IT BE SOMETHING DIFFERENT

3165
02:03:21,840 --> 02:03:28,480
IN ?

3166
02:03:28,480 --> 02:03:30,360
THERE'S THE BASE, WE DON'T LIKE

3167
02:03:30,360 --> 02:03:31,760
TO TOUCH THAT BECAUSE WE KNOW

3168
02:03:31,760 --> 02:03:33,120
WHAT COMES OUT OF THAT.

3169
02:03:33,120 --> 02:03:34,920
SO HOW IS THAT FRAMED?

3170
02:03:34,920 --> 02:03:35,320
IT'S PLANNING.

3171
02:03:35,320 --> 02:03:37,080
WE'RE A YEAR OR TWO AWAY, NOT

3172
02:03:37,080 --> 02:03:38,080
THAT FAR OUT.

3173
02:03:38,080 --> 02:03:39,280
IT'S ALREADY BEEN KICKED OFF

3174
02:03:39,280 --> 02:03:42,360
WITH A FEW PROGRAMS.

3175
02:03:42,360 --> 02:03:45,720
WE STILL DON'T KNOW HOW IT'S 

3176
02:03:45,720 --> 02:03:48,400
GOING TO BE FORMATTED.

3177
02:03:48,400 --> 02:03:50,560
>> WELL, I THINK THAT'S A
GOOD

3178
02:03:50,560 --> 02:03:50,800
POINT.

3179
02:03:50,800 --> 02:03:54,240
THERE ARE LOTS OF SUBMISSIONS.

3180
02:03:54,240 --> 02:03:56,280
PEOPLE ARE -- THERE WAS -- THEY

3181
02:03:56,280 --> 02:03:58,480
HAVE WHITE HOUSE STAFF THAT WILL

3182
02:03:58,480 --> 02:03:58,920
BEGIN TO PRIORITIZE.

3183
02:03:58,920 --> 02:04:01,160
I DON'T THINK IT WILL LOOK MUCH

3184
02:04:01,160 --> 02:04:02,960
LIKE THE LAST MOONSHOT.

3185
02:04:02,960 --> 02:04:05,960
I THINK IT IS MUCH, MUCH MORE

3186
02:04:05,960 --> 02:04:08,840
PATIENT FOCUSED AND DELIVERY OF

3187
02:04:08,840 --> 02:04:10,400
CARE FOCUSED, AND IMPROVING SOME

3188
02:04:10,400 --> 02:04:12,480
THINGS THAT WE'VE DISCUSSED

3189
02:04:12,480 --> 02:04:14,560
ACTUALLY AROUND ESPECIALLY

3190
02:04:14,560 --> 02:04:15,440
MINORITY AND UNDERSERVED

3191
02:04:15,440 --> 02:04:17,840
POPULATIONS, WHERE WE HAVE BIG

3192
02:04:17,840 --> 02:04:18,200
ISSUES.

3193
02:04:18,200 --> 02:04:21,000
SO, I THINK WE'RE GOING TO HAVE

3194
02:04:21,000 --> 02:04:22,560
TO WAIT AND SEE.

3195
02:04:22,560 --> 02:04:23,720
EVEN THE AMOUNT OF FUNDING THAT

3196
02:04:23,720 --> 02:04:25,280
WILL BE AVAILABLE, I DON'T THINK

3197
02:04:25,280 --> 02:04:26,360
WE YET KNOW.

3198
02:04:26,360 --> 02:04:26,680
>> RIGHT.

3199
02:04:26,680 --> 02:04:28,080
>> AND A LOT OF THIS IS
GOING TO

3200
02:04:28,080 --> 02:04:31,280
DEPEND ON OBVIOUSLY ON THE

3201
02:04:31,280 --> 02:04:33,920
ELECTION BUT I AM GLAD TO SEE IT

3202
02:04:33,920 --> 02:04:35,360
CONTINUING AND I THINK WE SHOULD

3203
02:04:35,360 --> 02:04:38,920
ALL BE HAPPY ABOUT THAT PART.

3204
02:04:38,920 --> 02:04:41,400
 

3205
02:04:41,400 --> 02:04:44,960
THANKS TO THE COMMITTEE.

3206
02:04:44,960 --> 02:04:47,560
I GUESS THE BYPASS BUDGET

3207
02:04:47,560 --> 02:04:49,800
PLANNING GETS UNDERWAY SOON AT

3208
02:04:49,800 --> 02:04:52,160
NCI, SO WE'LL BRING THAT BACK TO

3209
02:04:52,160 --> 02:04:58,800
THE COMMITTEE ONCE IT'S DONE. 

3210
02:04:58,800 --> 02:05:02,920
>> WE DO HAVE TIME FOR

3211
02:05:02,920 --> 02:05:04,040
ADDITIONAL QUESTION, AND I'LL

3212
02:05:04,040 --> 02:05:04,400
ASK A QUESTION.

3213
02:05:04,400 --> 02:05:06,760
I DON'T KNOW IF ANYONE CAN

3214
02:05:06,760 --> 02:05:09,360
ANSWER IT.

3215
02:05:09,360 --> 02:05:10,200
IT GOES BACK TO FREDERICK

3216
02:05:10,200 --> 02:05:12,080
NATIONAL LAB.

3217
02:05:12,080 --> 02:05:15,400
YOU KNOW, THINKING ABOUT THE OUT

3218
02:05:15,400 --> 02:05:18,280
YEARS, WHEN WILL THE CONTRACT BE

3219
02:05:18,280 --> 02:05:21,560
RECOMPETED AND HOW DOES THAT

3220
02:05:21,560 --> 02:05:23,360
SORT OF ROLL INTO FUTURE NCI

3221
02:05:23,360 --> 02:05:25,800
BUDGETS?

3222
02:05:25,800 --> 02:05:28,000
 

3223
02:05:28,000 --> 02:05:29,120
DOUG?

3224
02:05:29,120 --> 02:05:29,440
>> WELL --

3225
02:05:29,440 --> 02:05:32,960
>> THAT'S A DOUG QUESTION.

3226
02:05:32,960 --> 02:05:36,760
>> JOHN, THE RECOMPETE IS

3227
02:05:36,760 --> 02:05:40,800
SUPPOSED TO BE, YOU KNOW, MORE

3228
02:05:40,800 --> 02:05:42,160
OR LESS SEAMLESS.

3229
02:05:42,160 --> 02:05:49,000
IN OTHER WORDS, IT'S AN OPEN

3230
02:05:49,000 --> 02:05:50,280
COMPETITION.

3231
02:05:50,280 --> 02:05:51,760
THE CURRENT CONTRACTOR CAN APPLY

3232
02:05:51,760 --> 02:05:53,760
IF THEY WANT TO.

3233
02:05:53,760 --> 02:05:57,000
THEY CAN APPLY IN CONJUNCTION

3234
02:05:57,000 --> 02:06:00,840
WITH OTHER GROUPS IF THEY WANT

3235
02:06:00,840 --> 02:06:02,000
TO.

3236
02:06:02,000 --> 02:06:04,520
YOU KNOW, AND THERE WOULD BE

3237
02:06:04,520 --> 02:06:08,480
PRESUMABLY ONE OF TWO OUTCOMES.

3238
02:06:08,480 --> 02:06:12,520
THE CURRENT CONTRACTOR WOULD GET

3239
02:06:12,520 --> 02:06:14,400
THE NEW CONTRACT OR A DIFFERENT

3240
02:06:14,400 --> 02:06:15,680
GROUP WOULD GET THE NEW

3241
02:06:15,680 --> 02:06:18,920
CONTRACT.

3242
02:06:18,920 --> 02:06:23,080
AND THERE WOULD BE, IF YOU WILL,

3243
02:06:23,080 --> 02:06:24,920
A TRANSITION PERIOD.

3244
02:06:24,920 --> 02:06:29,480
BUT THE TRANSITION IS NOT A

3245
02:06:29,480 --> 02:06:31,400
WHOLESALE TURNOVER OF PERSONNEL.

3246
02:06:31,400 --> 02:06:35,280
THERE ARE WHAT ARE REFERRED TO

3247
02:06:35,280 --> 02:06:36,640
AS KEY PERSONNEL.

3248
02:06:36,640 --> 02:06:40,200
AND IT'S A LIMITED NUMBER.

3249
02:06:40,200 --> 02:06:45,120
IT'S FEWER THAN 10 THAT WOULD

3250
02:06:45,120 --> 02:06:45,480
TURN OVER.

3251
02:06:45,480 --> 02:06:47,560
BUT WHAT I'M TRYING TO SAY IS

3252
02:06:47,560 --> 02:06:51,640
THAT IT'S NOT AS THOUGH THE WORK

3253
02:06:51,640 --> 02:06:54,320
THAT WAS GOING ON WOULD STOP.

3254
02:06:54,320 --> 02:06:54,640
>> RIGHT.

3255
02:06:54,640 --> 02:06:57,200
I GUESS THE QUESTION IS THE

3256
02:06:57,200 --> 02:06:58,960
SCALE, RIGHT?

3257
02:06:58,960 --> 02:07:01,520
WILL THE FUNDING LEVELS, THE

3258
02:07:01,520 --> 02:07:03,520
SALE, BE THE SAME?

3259
02:07:03,520 --> 02:07:04,960
THESE ARE THE QUESTIONS I'M

3260
02:07:04,960 --> 02:07:05,400
GETTING AT.

3261
02:07:05,400 --> 02:07:06,680
>> I SEE.

3262
02:07:06,680 --> 02:07:11,640
I MEAN, WHAT HAPPENS IS THAT

3263
02:07:11,640 --> 02:07:13,400
BECAUSE THESE AWARDS ARE MADE

3264
02:07:13,400 --> 02:07:17,320
FOR A LONG TIME PERIOD, WE  TEND

3265
02:07:17,320 --> 02:07:22,200
-- YOU KNOW, WE TEND TO HAVE A

3266
02:07:22,200 --> 02:07:24,920
MAXIMUM -- YOU KNOW, RELATIVELY

3267
02:07:24,920 --> 02:07:28,680
HIGH MAXIMUM DOLLAR AMOUNT.

3268
02:07:28,680 --> 02:07:30,440
AND THE -- IT DOESN'T MEAN THAT

3269
02:07:30,440 --> 02:07:32,360
WE GET TO THAT AMOUNT.

3270
02:07:32,360 --> 02:07:34,920
IT'S JUST THAT IT'S FAR EASIER

3271
02:07:34,920 --> 02:07:39,360
TO SAY IT CAN GO UP TO A CERTAIN

3272
02:07:39,360 --> 02:07:40,800
AMOUNT THAN IT IS TO SAY, YOU

3273
02:07:40,800 --> 02:07:43,040
KNOW, LET'S SAY IT COULD BE $200

3274
02:07:43,040 --> 02:07:45,040
MILLION, BUT TURNS OUT YOU WANT

3275
02:07:45,040 --> 02:07:46,560
THREE, THAT'S MUCH HARDER THAN

3276
02:07:46,560 --> 02:07:49,120
TO SAY IT COULD BE FOUR, BUT WE

3277
02:07:49,120 --> 02:07:50,840
ONLY NEED THREE.

3278
02:07:50,840 --> 02:07:52,320
>> GOT IT.

3279
02:07:52,320 --> 02:07:53,200
THANKS, DOUG.

3280
02:07:53,200 --> 02:07:58,360
AGAIN, TO ME IT FALLS WITHIN THE

3281
02:07:58,360 --> 02:08:00,640
CONTEXT OF BUDGET AND PLANNING.

3282
02:08:00,640 --> 02:08:02,920
THANK YOU, DOUG.

3283
02:08:02,920 --> 02:08:05,480
WE NEED TO VOTE, PAULETTE, IS

3284
02:08:05,480 --> 02:08:06,200
THAT CORRECT?

3285
02:08:06,200 --> 02:08:09,160
>> YES, YOU NEED TO VOTE
ON EACH

3286
02:08:09,160 --> 02:08:11,720
REPORT INDIVIDUALLY.

3287
02:08:11,720 --> 02:08:14,640
>> OKAY.

3288
02:08:14,640 --> 02:08:14,880
GREAT. 

3289
02:08:14,880 --> 02:08:20,840
SO, WE NEED TO -- IS THERE A

3290
02:08:20,840 --> 02:08:23,200
MOTION TO APPROVE --

3291
02:08:23,200 --> 02:08:27,240
>> NOT TO APPROVE, TO
ACCEPT.

3292
02:08:27,240 --> 02:08:29,960
>> TO ACCEPT THE REPORT,

3293
02:08:29,960 --> 02:08:33,720
EXPERIMENTALITY SUBCOMMITTEE

3294
02:08:33,720 --> 02:08:34,200
REPORT.

3295
02:08:34,200 --> 02:08:34,720
>> ACCEPT.

3296
02:08:34,720 --> 02:08:36,760
>> IS THERE A SECOND?

3297
02:08:36,760 --> 02:08:37,240
>> SECOND.

3298
02:08:37,240 --> 02:08:38,880
>> IT'S BEEN PROPERLY
MOVED AND

3299
02:08:38,880 --> 02:08:39,160
SECONDED.

3300
02:08:39,160 --> 02:08:40,920
WE CAN NOW VOTE.

3301
02:08:40,920 --> 02:08:45,720
ARE THERE ANY NAYS?

3302
02:08:45,720 --> 02:08:47,920
THERE'S A HAND UP.

3303
02:08:47,920 --> 02:08:51,400
OH, THANKS, AMY.

3304
02:08:51,400 --> 02:08:52,080
OKAY, GREAT.

3305
02:08:52,080 --> 02:08:53,640
ANYONE NEED TO --

3306
02:08:53,640 --> 02:08:55,200
>> I THOUGHT YOU WERE
GOING

3307
02:08:55,200 --> 02:08:55,680
AFFIRMATIVE.

3308
02:08:55,680 --> 02:08:58,240
>> ANYONE NEED TO ABSTAIN?

3309
02:08:58,240 --> 02:08:58,440
OKAY.

3310
02:08:58,440 --> 02:09:01,520
SO, LOOKS LIKE WE HAVE A

3311
02:09:01,520 --> 02:09:04,520
UNANIMOUS VOTE TO ACCEPT THE

3312
02:09:04,520 --> 02:09:05,040
EXPERIMENTAL THERAPEUTICS

3313
02:09:05,040 --> 02:09:05,840
SUBCOMMITTEE REPORT.

3314
02:09:05,840 --> 02:09:06,520
>> OKAY.

3315
02:09:06,520 --> 02:09:08,680
AND THEN YOU NEED TO DO THE

3316
02:09:08,680 --> 02:09:09,840
PLANNING AND BUDGET.

3317
02:09:09,840 --> 02:09:14,560
>> SO, IS THERE A MOTION
TO

3318
02:09:14,560 --> 02:09:16,600
ACCEPT THE PLANNING AND BUDGET

3319
02:09:16,600 --> 02:09:19,000
SUBCOMMITTEE REPORT?

3320
02:09:19,000 --> 02:09:21,320
 

3321
02:09:21,320 --> 02:09:22,400
IS THERE A MOTION?

3322
02:09:22,400 --> 02:09:23,720
>> YES, THERE'S A MOTION.

3323
02:09:23,720 --> 02:09:26,520
>> IS THERE A SECOND?

3324
02:09:26,520 --> 02:09:28,400
IT'S BEEN PROPERLY MOVED AND

3325
02:09:28,400 --> 02:09:29,200
SECONDED.

3326
02:09:29,200 --> 02:09:31,920
NOW WE CAN VOTE.

3327
02:09:31,920 --> 02:09:33,480
VOTE TO ACCEPT THE REPORT.

3328
02:09:33,480 --> 02:09:37,520
ARE THERE ANY NAYS?

3329
02:09:37,520 --> 02:09:40,960
ANY ABSTENTIONS?

3330
02:09:40,960 --> 02:09:44,840
SO LOOKS UNANIMOUS.

3331
02:09:44,840 --> 02:09:48,920
>> SO, NOW, JOHN, WE'LL
MOVE

3332
02:09:48,920 --> 02:09:52,960
INTO FUTURE AGENDA ITEMS AND

3333
02:09:52,960 --> 02:09:53,880
OTHER AGENDA ITEMS.

3334
02:09:53,880 --> 02:09:56,120
WHEN HE MOVES INTO THIS

3335
02:09:56,120 --> 02:09:58,200
TERRITORY, THIS IS A GOOD TIME

3336
02:09:58,200 --> 02:10:01,960
FOR BOARD MEMBERS TO COME UP

3337
02:10:01,960 --> 02:10:04,080
WITH SUGGESTIONS, ET CETERA.

3338
02:10:04,080 --> 02:10:08,960
SO KAREN HAS HER HAND UP.

3339
02:10:08,960 --> 02:10:10,600
>> I SEE CHRIS AND KAREN.

3340
02:10:10,600 --> 02:10:12,560
LET'S START WITH CHRIS BECAUSE I

3341
02:10:12,560 --> 02:10:15,760
THINK HE HAD HIS HAND UP BEFORE.

3342
02:10:15,760 --> 02:10:16,280
>> OKAY.

3343
02:10:16,280 --> 02:10:16,920
>> THANKS SO MUCH.

3344
02:10:16,920 --> 02:10:20,360
THIS IS A FOLLOW-UP TO OUR

3345
02:10:20,360 --> 02:10:22,200
DISCUSSION WITH DR. BARKER'S

3346
02:10:22,200 --> 02:10:22,560
SUBCOMMITTEE.

3347
02:10:22,560 --> 02:10:24,000
OF THE BIG UNKNOWN OF ARPA-H, IF

3348
02:10:24,000 --> 02:10:25,960
YOU LOOK AT THE MINUTES FROM OUR

3349
02:10:25,960 --> 02:10:27,440
JUNE MEETING YOU'LL SEE I ASKED

3350
02:10:27,440 --> 02:10:29,240
THAT WE HAVE A REPRESENTATIVE

3351
02:10:29,240 --> 02:10:32,200
FROM ARPA-H PRESENT TO THIS

3352
02:10:32,200 --> 02:10:32,440
COMMITTEE.

3353
02:10:32,440 --> 02:10:34,400
IN OUR PLANNING FUNCTION, SO WE

3354
02:10:34,400 --> 02:10:35,520
CAN ADVISE THE NCI PROPERLY ON

3355
02:10:35,520 --> 02:10:37,200
FUTURE STRATEGY.

3356
02:10:37,200 --> 02:10:39,440
I'LL MAKE THAT REQUEST AGAIN.

3357
02:10:39,440 --> 02:10:42,600
NOW THAT DR. RUSSELL IS

3358
02:10:42,600 --> 02:10:44,160
APPOINTED, THAT DR. RUSSELL MEET

3359
02:10:44,160 --> 02:10:47,200
WITH US AT OUR NEXT SCHEDULED

3360
02:10:47,200 --> 02:10:47,440
MEETING.

3361
02:10:47,440 --> 02:10:50,280
>> THAT'S GREAT TIMING.

3362
02:10:50,280 --> 02:10:51,160
>> THANK YOU.

3363
02:10:51,160 --> 02:10:52,160
>> PERHAPS A PERMANENT
DIRECTOR

3364
02:10:52,160 --> 02:10:54,840
IN PLACE AS WELL, GREAT TIMING.

3365
02:10:54,840 --> 02:10:56,160
OKAY, KAREN?

3366
02:10:56,160 --> 02:10:57,160
>> YES, JOHN, THANKS.

3367
02:10:57,160 --> 02:11:00,080
I WOULD LIKE TO MAKE A REQUEST

3368
02:11:00,080 --> 02:11:01,200
THAT WHEN THE CANCER CENTER

3369
02:11:01,200 --> 02:11:02,720
SUBCOMMITTEE PRESENTS THAT THEY

3370
02:11:02,720 --> 02:11:04,960
PROVIDE SOME DATA TO US AROUND

3371
02:11:04,960 --> 02:11:06,440
WHICH OF THE COMPREHENSIVE

3372
02:11:06,440 --> 02:11:08,000
CANCER CENTERS DO NOT ACCEPT

3373
02:11:08,000 --> 02:11:10,240
MEDICAID SO THAT MAYBE WE CAN

3374
02:11:10,240 --> 02:11:12,440
PROVIDE SOME STRATEGIES AROUND

3375
02:11:12,440 --> 02:11:15,600
WAYS TO RETHINK HOW WE ARE

3376
02:11:15,600 --> 02:11:17,720
THINKING ABOUT ACCESSING AND

3377
02:11:17,720 --> 02:11:21,120
SUPPORT AROUND RESEARCH AND

3378
02:11:21,120 --> 02:11:22,120
CLINICAL TRIAL ENGAGEMENT.

3379
02:11:22,120 --> 02:11:22,440
>> RETHINK.

3380
02:11:22,440 --> 02:11:23,920
OKAY, GREAT.

3381
02:11:23,920 --> 02:11:25,920
I'LL TAKE THE CHAIR'S

3382
02:11:25,920 --> 02:11:28,720
PREROGATIVE BEFORE MOVING TO

3383
02:11:28,720 --> 02:11:29,680
HOWARD, WHICH IS IT WOULD BE

3384
02:11:29,680 --> 02:11:32,120
GREAT TO SEE THE TRAJECTORY OF

3385
02:11:32,120 --> 02:11:36,680
THE NUMBER OF ESI SUBMISSIONS

3386
02:11:36,680 --> 02:11:39,880
AND ESI-FUNDED GRANTS OVER SOME

3387
02:11:39,880 --> 02:11:40,120
PERIOD.

3388
02:11:40,120 --> 02:11:41,640
PARTICULARLY AT LEAST ONE OR TWO

3389
02:11:41,640 --> 02:11:43,480
OF THE COVID YEARS.

3390
02:11:43,480 --> 02:11:46,480
JUST TO LOOK AT THE TRAJECTORY,

3391
02:11:46,480 --> 02:11:47,080
RIGHT?

3392
02:11:47,080 --> 02:11:49,600
OF ESI GRANT SUBMISSIONS AND

3393
02:11:49,600 --> 02:11:50,880
THOSE THAT ARE FUNDED, OVER

3394
02:11:50,880 --> 02:11:52,240
MAYBE FIVE OR TEN YEARS.

3395
02:11:52,240 --> 02:11:53,600
THAT WOULD BE I THINK REALLY

3396
02:11:53,600 --> 02:11:56,320
GREAT TO SEE.

3397
02:11:56,320 --> 02:11:58,640
 

3398
02:11:58,640 --> 02:12:02,360
 

3399
02:12:02,360 --> 02:12:02,840
HOWARD?

3400
02:12:02,840 --> 02:12:06,200
>> YEAH, THANK YOU.

3401
02:12:06,200 --> 02:12:07,080
 

3402
02:12:07,080 --> 02:12:07,200
 

3403
02:12:07,200 --> 02:12:13,240
I'D LIKE TO PROPOSE A TIMELY

3404
02:12:13,240 --> 02:12:15,400
PRESENTATION ABOUT THE CURRENT

3405
02:12:15,400 --> 02:12:20,080
STATUS AND PLANS OF

3406
02:12:20,080 --> 02:12:21,040
IMMUNO-ONCOLOGY BIOMARKERS.

3407
02:12:21,040 --> 02:12:26,640
I'M AWARE THAT SOME SENIOR STAFF

3408
02:12:26,640 --> 02:12:30,160
WORKING ON THIS AT NCI HAVE

3409
02:12:30,160 --> 02:12:32,960
ALREADY STARTED TO LEARN FROM

3410
02:12:32,960 --> 02:12:35,840
PAST MISTAKES AND PITFALLS WITH

3411
02:12:35,840 --> 02:12:38,760
BIOMARKERS, AND COULD PROBABLY

3412
02:12:38,760 --> 02:12:41,400
HELP US AVOID THE SAME GOING

3413
02:12:41,400 --> 02:12:42,960
FORWARD, IF WE, YOU KNOW, WE

3414
02:12:42,960 --> 02:12:46,280
DON'T WANT TO, YOU KNOW, LET

3415
02:12:46,280 --> 02:12:47,320
HISTORY REPEAT ITSELF.

3416
02:12:47,320 --> 02:12:49,480
WE'D RATHER LEARN FROM HISTORY I

3417
02:12:49,480 --> 02:12:49,720
THINK.

3418
02:12:49,720 --> 02:12:50,440
AND MOVE FORWARD.

3419
02:12:50,440 --> 02:12:54,320
AND I THINK IT WOULD BE TIMELY

3420
02:12:54,320 --> 02:12:57,120
AGAIN BECAUSE OF THIS TRAINING

3421
02:12:57,120 --> 02:12:59,040
WORK THAT'S GOING ON, AND WE ALL

3422
02:12:59,040 --> 02:13:02,280
I THINK AGREE, I HOPE WE AGREE,

3423
02:13:02,280 --> 02:13:07,600
THAT THE MAJOR INVESTMENTS BY

3424
02:13:07,600 --> 02:13:10,880
THE SIMACs AND MOONSHOT

3425
02:13:10,880 --> 02:13:12,640
PROGRAM, IMMUNO-ONCOLOGY

3426
02:13:12,640 --> 02:13:13,600
BIOMARKERS APPLICABLE TO

3427
02:13:13,600 --> 02:13:15,040
ENRICHMENT FOR CELL THERAPIES,

3428
02:13:15,040 --> 02:13:16,000
GENE THERAPIES, ET CETERA, ARE

3429
02:13:16,000 --> 02:13:16,400
THEY IMPORTANT.

3430
02:13:16,400 --> 02:13:19,760
WE WANT TO GET IT RIGHT.

3431
02:13:19,760 --> 02:13:24,360
AND ALSO MAYBE HELP INFLUENCE

3432
02:13:24,360 --> 02:13:25,920
GRANT APPLICATIONS GOING FORWARD

3433
02:13:25,920 --> 02:13:28,280
AND OUR EVALUATION OF GRANT

3434
02:13:28,280 --> 02:13:28,640
APPLICATIONS.

3435
02:13:28,640 --> 02:13:29,400
>> ABSOLUTELY.

3436
02:13:29,400 --> 02:13:33,400
IT'S A GREAT POINT.

3437
02:13:33,400 --> 02:13:34,680
SO, IMMUNOTHERAPEUTIC BIOMARKERS

3438
02:13:34,680 --> 02:13:37,760
AND WHAT'S HAPPENING INTERNALLY

3439
02:13:37,760 --> 02:13:40,280
AT THE NCI, AND SO IT'S GREAT.

3440
02:13:40,280 --> 02:13:42,760
THANKS, HOWARD.

3441
02:13:42,760 --> 02:13:43,120
FANTASTIC.

3442
02:13:43,120 --> 02:13:45,440
SO WE'RE RIGHT AT THE TOP OF THE

3443
02:13:45,440 --> 02:13:45,960
HOUR.

3444
02:13:45,960 --> 02:13:49,840
AND SO THIS WOULD CONCLUDE THE

3445
02:13:49,840 --> 02:13:51,360
OPEN SESSION OF THE NCAB

3446
02:13:51,360 --> 02:13:51,920
MEETING.

3447
02:13:51,920 --> 02:13:54,240
THERE WILL BE A 10-MINUTE BREAK,

3448
02:13:54,240 --> 02:13:56,360
ONLY BOARD MEMBERS AND

3449
02:13:56,360 --> 02:13:57,880
DESIGNATED NCI STAFF SHOULD

3450
02:13:57,880 --> 02:13:58,280
RETURN.

3451
02:13:58,280 --> 02:14:02,280
ALL SHOULD SIGN OFF THIS LINK

3452
02:14:02,280 --> 02:14:03,200
AND UTILIZE THE NEW WEB LINK FOR

3453
02:14:03,200 --> 02:14:04,240
THE CLOSED SESSION, WITHIN TEN

3454
02:14:04,240 --> 02:14:05,560
MINUTES.

3455
02:14:05,560 --> 02:14:06,080
THANK YOU ALL FOR ATTENDING

3456
02:14:06,080 --> 00:00:00,000
TODAY'S MEETING.