1 00:00:11,280 --> 00:00:13,560 ... THE EX OFFICIO MEMBERS, 2 00:00:13,560 --> 00:00:15,600 PRESIDENT CANCER MEMBER STAFF 3 00:00:15,600 --> 00:00:18,560 AND GUESTS, THERE ARE REQUIRED 4 00:00:18,560 --> 00:00:18,920 ANNOUNCEMENTS. 5 00:00:18,920 --> 00:00:23,480 MEMBERS OF THE PUBLIC MAY WISH 6 00:00:23,480 --> 00:00:25,760 TO EXPRESS THEIR VIEWS REGARDING 7 00:00:25,760 --> 00:00:27,720 ANY ITEMS DISCUSSED DURING THIS 8 00:00:27,720 --> 00:00:31,240 MEETING MAY WRITE TO DR. 9 00:00:31,240 --> 00:00:31,920 PAULETTE GRAY, EXECUTIVE 10 00:00:31,920 --> 00:00:33,680 SECRETARY OF THE BOARD, WITHIN 11 00:00:33,680 --> 00:00:37,160 TEN DAYS AFTER THE MEETING. 12 00:00:37,160 --> 00:00:38,240 ANY WRITTEN STATEMENTS OR 13 00:00:38,240 --> 00:00:39,120 QUESTIONS SUBMITTED BY MEMBERS 14 00:00:39,120 --> 00:00:41,960 OF THE PUBLIC WILL RECEIVE 15 00:00:41,960 --> 00:00:43,680 CAREFUL CONSIDERATION. 16 00:00:43,680 --> 00:00:50,000 AS BOARD MEMBERS, I 17 00:00:50,000 --> 00:00:52,200 WANT TO REMIND YOU YOU MUST 18 00:00:52,200 --> 00:00:54,080 ABSENT YOURSELVES ON A 19 00:00:54,080 --> 00:00:57,000 PARTICULAR PRODUCT, PROGRAM, OR 20 00:00:57,000 --> 00:00:59,000 OTHER SPECIFIC MATTER WHERE IT 21 00:00:59,000 --> 00:01:00,320 WOULD CONSTITUTE CONFLICT OF 22 00:01:00,320 --> 00:01:01,920 INTEREST OR CREATE THE 23 00:01:01,920 --> 00:01:04,360 APPEARANCE OF ONE. 24 00:01:04,360 --> 00:01:07,200 IT'S INCUMBENT ON YOU TO ABSTAIN 25 00:01:07,200 --> 00:01:07,960 FROM PARTICIPATION AND 26 00:01:07,960 --> 00:01:09,760 DISCUSSION OR ACTION REGARDING 27 00:01:09,760 --> 00:01:10,280 THAT MATTER. 28 00:01:10,280 --> 00:01:14,040 IN LIGHT OF THE CURRENT POLICIES 29 00:01:14,040 --> 00:01:16,240 CONFLICT OF INTEREST BASED ON 30 00:01:16,240 --> 00:01:17,480 FINANCIAL HOLDINGS FOR SPECIAL 31 00:01:17,480 --> 00:01:18,120 GOVERNMENT EMPLOYEES WHICH 32 00:01:18,120 --> 00:01:20,000 INCLUDES ALL MEMBERS OF THE 33 00:01:20,000 --> 00:01:25,840 BOARD WE MUST DEPEND ON YOU TO 34 00:01:25,840 --> 00:01:27,640 VOLUNTARILY ABSTENT YOURSELVES 35 00:01:27,640 --> 00:01:28,240 DURING DISCUSSIONS OF MATTERS 36 00:01:28,240 --> 00:01:30,840 THAT COULD IMPACT THE STATUS OF 37 00:01:30,840 --> 00:01:32,320 THESE HOLDINGS. 38 00:01:32,320 --> 00:01:33,320 WE THURSDAY YOUR JUDGMENT SO 39 00:01:33,320 --> 00:01:37,600 PLEASE MAKE SURE TO ABSTAIN WHEN 40 00:01:37,600 --> 00:01:39,120 APPROPRIATE. 41 00:01:39,120 --> 00:01:41,040 DURING ANY CLOSED SESSIONS, ANY 42 00:01:41,040 --> 00:01:43,800 MATERIALS OR DISCUSSIONS OF A 43 00:01:43,800 --> 00:01:45,360 CONFIDENTIAL NATURE DELIBERATED 44 00:01:45,360 --> 00:01:48,520 ON TODAY ARE PRIVILEGED 45 00:01:48,520 --> 00:01:49,920 INFORMATION AND MAY ALSO BE 46 00:01:49,920 --> 00:01:52,880 AVAILABLE TO YOU ON A 47 00:01:52,880 --> 00:01:53,880 NEED-TO-KNOW BASIS, SUCH 48 00:01:53,880 --> 00:01:55,360 DELIBERATIONS ARE PRIVATE AND 49 00:01:55,360 --> 00:01:59,000 THEIR CONTENTS SHOULD NOT BE 50 00:01:59,000 --> 00:01:59,520 DIVULGED. 51 00:01:59,520 --> 00:02:02,560 SO, WE HAVE THE FUTURE MEETING 52 00:02:02,560 --> 00:02:04,240 DATES, PROVIDED TO YOU AND ARE 53 00:02:04,240 --> 00:02:08,720 ALSO LISTED ON THE AGENDA SO 54 00:02:08,720 --> 00:02:13,080 THAT YOU CAN SEE WHEN OUR NEXT 55 00:02:13,080 --> 00:02:14,640 MEETINGS ARE, JOINT MEETINGS, 56 00:02:14,640 --> 00:02:15,400 NCAB MEETINGS. 57 00:02:15,400 --> 00:02:18,680 SO NEXT UP IS APPROVAL OF THE 58 00:02:18,680 --> 00:02:22,320 SUMMARY FOR THE DECEMBER 7-9, 59 00:02:22,320 --> 00:02:25,640 2021, JOINT BSA/NCAB VIRTUAL 60 00:02:25,640 --> 00:02:25,880 MEETING. 61 00:02:25,880 --> 00:02:28,200 I'D LIKE TO ASK DO WE HAVE A 62 00:02:28,200 --> 00:02:34,440 MOTION TO APPROVE THE SUMMARY? 63 00:02:34,440 --> 00:02:39,240 A SECOND? 64 00:02:39,240 --> 00:02:39,920 >> SECOND. 65 00:02:39,920 --> 00:02:40,280 >> DISCUSSION? 66 00:02:40,280 --> 00:02:42,600 SO, PLEASE VOTE YAY, NAY, OR 67 00:02:42,600 --> 00:02:43,280 ABSTAIN. 68 00:02:43,280 --> 00:02:46,560 DO WE HAVE ANY NAYS? 69 00:02:46,560 --> 00:02:51,120 70 00:02:51,120 --> 00:02:54,760 THANK YOU. 71 00:02:54,760 --> 00:02:56,240 SO BY LAW, A QUORUM IS REQUIRED 72 00:02:56,240 --> 00:02:58,480 FOR A VOTE TO OCCUR, WHETHER IN 73 00:02:58,480 --> 00:03:00,400 OPEN OR CLOSED SESSION. 74 00:03:00,400 --> 00:03:02,200 DURING THIS MEETING MINIMUM OF 75 00:03:02,200 --> 00:03:04,240 NINE APPOINTED MEMBERS OF THE 76 00:03:04,240 --> 00:03:07,280 NCAB MUST BE PRESENT TO VOICE 77 00:03:07,280 --> 00:03:07,720 THEIR VOTES. 78 00:03:07,720 --> 00:03:10,320 SINCE WE CAN'T PREDICT THE TIME 79 00:03:10,320 --> 00:03:11,880 OR OCCURRENCE OF ANY MOTION, 80 00:03:11,880 --> 00:03:13,600 YOUR PRESENCE IN THE VIRTUAL 81 00:03:13,600 --> 00:03:16,560 ROOM FOR ALL SEGMENTS OF THE 82 00:03:16,560 --> 00:03:18,520 MEETING IS NECESSARY, AND IT'S A 83 00:03:18,520 --> 00:03:18,720 MUST. 84 00:03:18,720 --> 00:03:22,440 PAULETTE, DO WE HAVE A QUORUM? 85 00:03:22,440 --> 00:03:23,680 >> YES, WE DO. 86 00:03:23,680 --> 00:03:26,080 >> TO ENSURE NO INTERRUPTIONS 87 00:03:26,080 --> 00:03:26,800 DURING THE MEETINGS, PLEASE 88 00:03:26,800 --> 00:03:30,000 ENSURE THAT YOU ARE MUTED AND 89 00:03:30,000 --> 00:03:32,200 REMAIN SO UNTIL RECOGNIZED BY 90 00:03:32,200 --> 00:03:36,920 EITHER ME, PAULETTE, NED OR THE 91 00:03:36,920 --> 00:03:37,120 SPEAKER. 92 00:03:37,120 --> 00:03:38,760 AND WE ALWAYS HAVE THE CELL 93 00:03:38,760 --> 00:03:41,040 PHONE ISSUES BUT MAKE SURE 94 00:03:41,040 --> 00:03:41,360 YOU'RE MUTED. 95 00:03:41,360 --> 00:03:43,760 NEXT ITEM OF BUSINESS ON OUR 96 00:03:43,760 --> 00:03:46,160 AGENDA WILL BE THE NCI 97 00:03:46,160 --> 00:03:48,880 DIRECTOR'S REPORT PROVIDED BY 98 00:03:48,880 --> 00:03:50,560 DR. NED SHARPLESS, DIRECTOR OF 99 00:03:50,560 --> 00:03:52,320 THE NCI. 100 00:03:52,320 --> 00:03:52,480 NED? 101 00:03:52,480 --> 00:03:53,360 >> THANKS, JOHN. 102 00:03:53,360 --> 00:03:54,280 GOOD AFTERNOON, EVERYONE. 103 00:03:54,280 --> 00:03:57,000 GOOD TO SEE YOU AGAIN VIRTUALLY. 104 00:03:57,000 --> 00:03:59,200 I WANT TO APOLOGIZE TO THE 105 00:03:59,200 --> 00:04:00,320 GLOBAL HEALTH SUBCOMMITTEE FOR 106 00:04:00,320 --> 00:04:01,760 ZOOM BOMBING THEIR MEETING. 107 00:04:01,760 --> 00:04:04,680 I HAD COMPUTER DRAMA BUT I 108 00:04:04,680 --> 00:04:05,760 BELIEVE IT'S FIXED. 109 00:04:05,760 --> 00:04:08,640 I ASSUME YOU CAN HEAR ME. 110 00:04:08,640 --> 00:04:08,920 >> YES. 111 00:04:08,920 --> 00:04:09,200 >> GREAT. 112 00:04:09,200 --> 00:04:13,400 SO I THOUGHT I WOULD TALK ABOUT 113 00:04:13,400 --> 00:04:16,080 THE PAST, NCA 50 BRIEFLY ON 114 00:04:16,080 --> 00:04:16,520 THAT. 115 00:04:16,520 --> 00:04:19,680 A LITTLE BIT ABOUT FY 22, STILL 116 00:04:19,680 --> 00:04:21,520 VERY MUCH CURRENT TOPIC OF 117 00:04:21,520 --> 00:04:26,560 BUSINESS, AND M.K. HOLOHAN WILL 118 00:04:26,560 --> 00:04:28,520 TALK ABOUT THAT AND PRESIDENT'S 119 00:04:28,520 --> 00:04:33,000 ANNOUNCEMENT AROUND THE NEW 120 00:04:33,000 --> 00:04:35,320 CANCER MOONSHOT, SUPER CHARGED 121 00:04:35,320 --> 00:04:37,040 MOONSHOT AS THE PRESIDENT CALLS 122 00:04:37,040 --> 00:04:38,080 IT AND LEAVE TIME FOR 123 00:04:38,080 --> 00:04:38,480 DISCUSSION. 124 00:04:38,480 --> 00:04:39,480 NEXT SLIDE PLEASE. 125 00:04:39,480 --> 00:04:41,200 WHEN WE LAST MET AS A WHOLE 126 00:04:41,200 --> 00:04:42,520 GROUP IN EARLY DECEMBER WE WERE 127 00:04:42,520 --> 00:04:46,040 STILL A FEW WEEKS OUT FROM THE 128 00:04:46,040 --> 00:04:47,440 ACTUAL SIGNING OF THE NATIONAL 129 00:04:47,440 --> 00:04:50,240 CANCER ACT ON DECEMBER 23, A 130 00:04:50,240 --> 00:04:56,920 REALLY GREAT I THINK SORT OF 131 00:04:56,920 --> 00:04:58,960 TSUNAMI OF INTEREST ACROSS THE 132 00:04:58,960 --> 00:05:00,520 CANCER RESEARCH COMMUNITY WITH 133 00:05:00,520 --> 00:05:02,280 GREAT BUY IN FROM EVERYONE 134 00:05:02,280 --> 00:05:04,320 INTERESTED IN CANCER RESEARCH TO 135 00:05:04,320 --> 00:05:07,280 TALK ABOUT THIS AREA, INCLUDING 136 00:05:07,280 --> 00:05:10,280 GREAT PICKUP IN THE MEDIA. 137 00:05:10,280 --> 00:05:13,200 WE WERE DELIGHTED WHEN THE FIRST 138 00:05:13,200 --> 00:05:15,520 LADY PROVIDED A WONDERFUL VIDEO 139 00:05:15,520 --> 00:05:18,360 IN HONOR OF THE 50th 140 00:05:18,360 --> 00:05:19,040 ANNIVERSARY, ENUNCIATED PROGRESS 141 00:05:19,040 --> 00:05:20,120 THAT REMAINS AND SOME CHALLENGES 142 00:05:20,120 --> 00:05:22,680 THAT REMAIN BUT ALSO TALKING 143 00:05:22,680 --> 00:05:23,040 ABOUT PROGRESS. 144 00:05:23,040 --> 00:05:24,320 I'D LIKE TO PLAY IT BRIEFLY -- 145 00:05:24,320 --> 00:05:25,880 PLAY IT IF THE A V TEAM COULD 146 00:05:25,880 --> 00:05:28,880 QUEUE THIS UP 147 00:05:28,880 --> 00:05:29,520 >> RESEARCHERS, POLICYMAKERS, 148 00:05:29,520 --> 00:05:32,560 PATIENTS, SURVIVORS. 149 00:05:32,560 --> 00:05:36,440 50 YEARS AGO A DEDICATED 150 00:05:36,440 --> 00:05:40,040 COALITION OF ADVOCATES CAME 151 00:05:40,040 --> 00:05:41,160 TOGETHER TO WITNESS PRESIDENT 152 00:05:41,160 --> 00:05:42,520 NIXON SIGN THE NATIONAL CANCER 153 00:05:42,520 --> 00:05:44,280 ACT OF 1971. 154 00:05:44,280 --> 00:05:46,560 ON THAT DECEMBER DAY, THE UNITED 155 00:05:46,560 --> 00:05:48,480 STATES WROTE THE FIRST CHAPTER 156 00:05:48,480 --> 00:05:52,040 IN OUR UNIFIED FIGHT AGAINST 157 00:05:52,040 --> 00:05:52,400 CANCER. 158 00:05:52,400 --> 00:05:55,560 SINCE THEN, WE'VE INVESTED IN 159 00:05:55,560 --> 00:05:57,880 PEOPLE AND SCIENCE, ADVANCING 160 00:05:57,880 --> 00:05:59,480 CANCER SCREENING, PREVENTION, 161 00:05:59,480 --> 00:06:01,640 DIAGNOSIS, AND TREATMENT. 162 00:06:01,640 --> 00:06:04,040 WE'VE HELPED MILLIONS OF 163 00:06:04,040 --> 00:06:06,560 PATIENTS LIVE LONGER, FULLER 164 00:06:06,560 --> 00:06:06,880 LIVES. 165 00:06:06,880 --> 00:06:09,680 BUT DESPITE OUR TREMENDOUS 166 00:06:09,680 --> 00:06:10,480 PROGRESS, THE HEARTBREAKING 167 00:06:10,480 --> 00:06:12,320 REALITY IS THAT CANCER IS STILL 168 00:06:12,320 --> 00:06:15,280 A LEADING CAUSE OF DEATH IN OUR 169 00:06:15,280 --> 00:06:15,720 COUNTRY. 170 00:06:15,720 --> 00:06:18,160 WE STILL DON'T HAVE ENOUGH 171 00:06:18,160 --> 00:06:19,880 METHODS TO PREVENT IT. 172 00:06:19,880 --> 00:06:21,880 SOME TREATMENTS COME WITH 173 00:06:21,880 --> 00:06:23,200 SERIOUS SIDE EFFECTS. 174 00:06:23,200 --> 00:06:28,080 AND INEQUITIES LEAD TO FAR TOO 175 00:06:28,080 --> 00:06:31,400 MANY LIVES LOST. 176 00:06:31,400 --> 00:06:32,080 IN 1971, THEN-PRESIDENT NIXON 177 00:06:32,080 --> 00:06:34,480 CALLED FOR A TOTAL NATIONAL 178 00:06:34,480 --> 00:06:37,480 COMMITMENT TO FINDING A CURE. 179 00:06:37,480 --> 00:06:40,080 NOW, WE'RE READY TO DO MORE. 180 00:06:40,080 --> 00:06:43,320 TO END CANCER AS WE KNOW IT. 181 00:06:43,320 --> 00:06:46,280 IT'S AN AMBITIOUS GOAL, BUT FROM 182 00:06:46,280 --> 00:06:47,480 BRILLIANT RESEARCHERS TO 183 00:06:47,480 --> 00:06:50,080 PASSIONATE PROVIDERS TO INFORMED 184 00:06:50,080 --> 00:06:52,040 AND ENGAGED PATIENTS, I'VE SEEN 185 00:06:52,040 --> 00:06:55,760 THE HEART AND GRIT OF OUR 186 00:06:55,760 --> 00:06:56,080 COMMUNITIES. 187 00:06:56,080 --> 00:06:59,480 THERE IS NOTHING OUT OF OUR 188 00:06:59,480 --> 00:06:59,680 REACH. 189 00:06:59,680 --> 00:07:02,800 CANCER IS PART OF THE BIDEN 190 00:07:02,800 --> 00:07:03,120 FAMILY STORY. 191 00:07:03,120 --> 00:07:07,720 IT'S PART OF SO MANY AMERICAN 192 00:07:07,720 --> 00:07:07,960 STORIES. 193 00:07:07,960 --> 00:07:11,080 CANCER TOUCHES US ALL. 194 00:07:11,080 --> 00:07:13,200 BUT TOGETHER WE CAN CHANGE THAT 195 00:07:13,200 --> 00:07:13,400 STORY. 196 00:07:13,400 --> 00:07:15,960 WE CAN END THE TRAGEDY OF CANCER 197 00:07:15,960 --> 00:07:18,240 AS WE KNOW IT. 198 00:07:18,240 --> 00:07:25,280 AND NOTHING WILL STOP US. 199 00:07:25,280 --> 00:07:27,520 >>AS I SAID, WE FOUND THAT 200 00:07:27,520 --> 00:07:30,800 TREMENDOUSLY COMPELLING AND ARE 201 00:07:30,800 --> 00:07:31,520 GRATEFUL FOR THE WHITE HOUSE'S 202 00:07:31,520 --> 00:07:32,280 SUPPORT, PARTICULARLY THE FIRST 203 00:07:32,280 --> 00:07:34,960 LADY'S. A REAL FRIEND OF CANCER 204 00:07:34,960 --> 00:07:37,920 RESEARCH. 205 00:07:37,920 --> 00:07:40,360 SO LET ME BRIEFLY SAY A COUPLE 206 00:07:40,360 --> 00:07:41,640 WORDS ABOUT 22, STILL A TOP 207 00:07:41,640 --> 00:07:43,600 ORDER OF BUSINESS AS I SAID M.K. 208 00:07:43,600 --> 00:07:44,920 WILL HAVE MORE TO SAY. 209 00:07:44,920 --> 00:07:46,600 AS A REMINDER I TRY AND SHOW 210 00:07:46,600 --> 00:07:49,800 THIS SLIDE WHEN I SPEAK TO THE 211 00:07:49,800 --> 00:07:50,000 NCAB. 212 00:07:50,000 --> 00:07:51,320 YOU SEE OUR ALLOCATION FOR THE 213 00:07:51,320 --> 00:07:55,160 LAST COUPLE YEARS AS WELL AS THE 214 00:07:55,160 --> 00:07:57,840 PRESIDENT'S BUDGET MARK AND 215 00:07:57,840 --> 00:08:01,880 HOUSE MARK FOR 2022 TO THE FAR 216 00:08:01,880 --> 00:08:03,880 RIGHT, ORANGE BARS REPRESENTING 217 00:08:03,880 --> 00:08:06,840 THE 21st CURES WHICH FUNDED 218 00:08:06,840 --> 00:08:07,480 ORIGINAL CANCER MOONSHOT AND $50 219 00:08:07,480 --> 00:08:11,880 MILLION IN 20 FOR THE CCDI, END 220 00:08:11,880 --> 00:08:16,040 OF ITS SECOND YEAR, WHITE BOX TO 221 00:08:16,040 --> 00:08:17,000 INDICATE ONE-TIME MULTI-YEAR 222 00:08:17,000 --> 00:08:19,120 FUNDING FOR CORONAVIRUS RESEARCH 223 00:08:19,120 --> 00:08:20,600 THAT THE NCI CONTINUES TO DO. 224 00:08:20,600 --> 00:08:24,240 WE'RE STILL IN A CONTINUED 225 00:08:24,240 --> 00:08:25,200 RESOLUTION. 226 00:08:25,200 --> 00:08:27,080 WE'VE HAD SOME MEMBERS OF THE 227 00:08:27,080 --> 00:08:27,920 CONGRESS TALK ABOUT THE 228 00:08:27,920 --> 00:08:30,160 POSSIBILITY EVEN OF A FULL YEAR 229 00:08:30,160 --> 00:08:31,160 CONTINUING RESOLUTION WHICH 230 00:08:31,160 --> 00:08:34,000 WOULD BE VERY PROBLEMATIC FOR 231 00:08:34,000 --> 00:08:34,840 THE NCI. 232 00:08:34,840 --> 00:08:36,000 WE'VE SEEN PROGRESS AND 233 00:08:36,000 --> 00:08:37,560 OPTIMISTIC STUFF IN THE LAST FEW 234 00:08:37,560 --> 00:08:40,960 WEEKS THAT M.K. WILL TALK ABOUT. 235 00:08:40,960 --> 00:08:43,160 BUT THIS, YOU KNOW, LACK OF 236 00:08:43,160 --> 00:08:46,000 HAVING A 22 BUDGET AS YOU CAN 237 00:08:46,000 --> 00:08:47,640 IMAGINE PROVIDES SOME BUDGETARY 238 00:08:47,640 --> 00:08:49,520 CHALLENGES AND PLANNING 239 00:08:49,520 --> 00:08:50,600 CHALLENGES FORT NATIONAL CANCER 240 00:08:50,600 --> 00:08:52,640 INSTITUTE, MOST IMPORTANT IS 241 00:08:52,640 --> 00:08:54,000 SHOWN ON THE NEXT SLIDE. 242 00:08:54,000 --> 00:08:55,960 WHICH IS WE STILL OPERATE UNDER 243 00:08:55,960 --> 00:09:03,960 THESE VERY LOW INTERIM PAYLINES 244 00:09:03,960 --> 00:09:08,400 FOR 2022, 19th AND 14th, 245 00:09:08,400 --> 00:09:10,760 FUNDING NON-COMPETING AT 90% 246 00:09:10,760 --> 00:09:13,320 DURING THIS PERIOD OF 247 00:09:13,320 --> 00:09:13,600 UNCERTAINTY. 248 00:09:13,600 --> 00:09:14,760 WE HOPE AND BELIEVE THAT ONCE 249 00:09:14,760 --> 00:09:16,840 BUDGET IS PASSED WE WILL BE ABLE 250 00:09:16,840 --> 00:09:18,280 TO IMPROVE THESE INTERIM 251 00:09:18,280 --> 00:09:19,160 PAYLINES AND PARTICULARLY 252 00:09:19,160 --> 00:09:22,200 IMPROVE THE FUNDING FOR 253 00:09:22,200 --> 00:09:22,680 NON-COMPETING GRANTS. 254 00:09:22,680 --> 00:09:23,960 BUT WE'RE NOT OUT OF THE WOODS 255 00:09:23,960 --> 00:09:24,280 YET. 256 00:09:24,280 --> 00:09:26,680 I HAD THE OPPORTUNITY TO TALK TO 257 00:09:26,680 --> 00:09:28,440 ONE OF THE APPROPRIATORS, TOM 258 00:09:28,440 --> 00:09:30,200 COLE, ABOUT THIS. 259 00:09:30,200 --> 00:09:31,400 AND AT THE CANCER MOONSHOT 260 00:09:31,400 --> 00:09:31,760 EVENT. 261 00:09:31,760 --> 00:09:33,800 HE TOLD ME THAT HE THOUGHT THEY 262 00:09:33,800 --> 00:09:34,960 WOULD GET A BUDGET. 263 00:09:34,960 --> 00:09:36,600 THEY ARE MAKING PROGRESS, BUT 264 00:09:36,600 --> 00:09:38,800 THE FULL YEAR C.R. IS STILL 265 00:09:38,800 --> 00:09:42,280 SOMETHING WE HAVE TO WORRY B 266 00:09:42,280 --> 00:09:43,600 STAY TUNED. 267 00:09:43,600 --> 00:09:45,800 M.K. WILL HAVE MORE TO SAY. 268 00:09:45,800 --> 00:09:59,760 I WANT TO POINT TO THIS IN 269 00:09:59,760 --> 00:10:01,960 SCIENTIFIC AMERICA BY SENATOR 270 00:10:01,960 --> 00:10:03,160 COONS AND MORAN, TALKING ABOUT 271 00:10:03,160 --> 00:10:05,000 THE SUPPORT THEY THINK CONGRESS 272 00:10:05,000 --> 00:10:06,640 SHOULD PROVIDE TO REALLY HELP US 273 00:10:06,640 --> 00:10:09,520 BEAT CANCER AS THEY CALL IT. 274 00:10:09,520 --> 00:10:12,440 IT'S GREAT TO HEAR THIS KIND OF 275 00:10:12,440 --> 00:10:13,640 BIPARTISAN INTEREST IN 276 00:10:13,640 --> 00:10:14,600 SUPPORTING CANCER RESEARCH, THEY 277 00:10:14,600 --> 00:10:18,200 AT THE SAME TIME QUEER -- WE'RE 278 00:10:18,200 --> 00:10:19,360 BEGINNING TO DISCUSS WHAT COMES 279 00:10:19,360 --> 00:10:22,640 NEXT IN THE CANCER MOONSHOT. 280 00:10:22,640 --> 00:10:26,120 YOU CAN SEE THE WHITE HOUSE IS 281 00:10:26,120 --> 00:10:28,000 INTERESTED IN ENDING CANCER, 282 00:10:28,000 --> 00:10:30,240 MAKING PROGRESS, CONGRESS HAS 283 00:10:30,240 --> 00:10:31,160 SHOWN WILLINGNESS OVER SEVERAL 284 00:10:31,160 --> 00:10:35,520 YEARS AND INTEREST IN PROVIDING 285 00:10:35,520 --> 00:10:36,360 FOR CANCER RESEARCH PERSISTING 286 00:10:36,360 --> 00:10:38,160 THROUGH TODAY AND WE HAVE A 287 00:10:38,160 --> 00:10:39,360 COMMUNITY OF RESEARCHERS AND 288 00:10:39,360 --> 00:10:40,320 SCIENTISTS AND PATIENT ADVOCATES 289 00:10:40,320 --> 00:10:41,760 THAT WANT TO DO THAT TOO. 290 00:10:41,760 --> 00:10:45,200 THE STARS ARE FAVORABLY ALIGNED 291 00:10:45,200 --> 00:10:52,480 FOR PROGRESS AGAINST CANCER. 292 00:10:52,480 --> 00:10:53,480 NEXT SLIDE. 293 00:10:53,480 --> 00:10:55,480 WE HAD THIS EVENT WEDNESDAY 294 00:10:55,480 --> 00:10:57,360 WHERE PRESIDENT BIDEN ANNOUNCE 295 00:10:57,360 --> 00:11:01,280 PLANS TO SUPER CHARGE THE CANCER 296 00:11:01,280 --> 00:11:03,640 MOONSHOT, A BIG MOMENT FOR 297 00:11:03,640 --> 00:11:05,880 NATIONAL CANCER INSTITUTE AND IN 298 00:11:05,880 --> 00:11:07,440 GENERAL, PRESIDENT SAID FIGHTING 299 00:11:07,440 --> 00:11:10,040 CANCER IS A TOP PRIORITY, 300 00:11:10,040 --> 00:11:11,480 EXPRESSED EXUBERANCE FOR THE 301 00:11:11,480 --> 00:11:13,360 PROGRESS OF THE CANCER MOONSHOT. 302 00:11:13,360 --> 00:11:16,040 IT'S IMPORTANT TO NOTE THE 303 00:11:16,040 --> 00:11:17,600 SUCCESS OF THE MOONSHOT LAUNCHED 304 00:11:17,600 --> 00:11:21,880 IN 2016 LED BY DR. DINAH SINGER, 305 00:11:21,880 --> 00:11:23,520 A CONTRIBUTING FACTOR TO 306 00:11:23,520 --> 00:11:25,760 PROGRESS OVER FIVE YEARS, THIS 307 00:11:25,760 --> 00:11:27,800 IS WHAT THE PRESIDENT POINTED TO 308 00:11:27,800 --> 00:11:29,200 AS ENABLING THIS BROADER AND 309 00:11:29,200 --> 00:11:31,000 MORE AMBITIOUS SET OF GOALS. 310 00:11:31,000 --> 00:11:33,680 THE EVENT LAST WEDNESDAY WAS THE 311 00:11:33,680 --> 00:11:35,080 KICKOFF, STEP ONE, HE LAID 312 00:11:35,080 --> 00:11:37,480 IMPORTANT GOALS AND TALKED ABOUT 313 00:11:37,480 --> 00:11:38,240 HIS PRIORITIES. 314 00:11:38,240 --> 00:11:40,360 I'VE SEEN FIRST HAND THE PASSION 315 00:11:40,360 --> 00:11:44,800 AND COMPASSION OF TH BIDEN, THIS 316 00:11:44,800 --> 00:11:46,800 IS A POWERFUL EXAMPLE OF THEIR 317 00:11:46,800 --> 00:11:47,200 COMMITMENT. 318 00:11:47,200 --> 00:11:48,560 THIS TRANSCENDS ALL OF 319 00:11:48,560 --> 00:11:50,600 GOVERNMENT, BIGGER THAN ANY ONE 320 00:11:50,600 --> 00:11:53,000 AGENCY OR OFFICE. 321 00:11:53,000 --> 00:11:55,520 I HAVE COMPLETE CONFIDENCE 322 00:11:55,520 --> 00:11:58,360 PRESIDENT BIDEN WILL ENSURE THIS 323 00:11:58,360 --> 00:11:59,440 STAYS ON TRACK, CHANGING THE 324 00:11:59,440 --> 00:12:00,840 EXPERIENCE OF PATIENTS WITH 325 00:12:00,840 --> 00:12:01,080 CANCER. 326 00:12:01,080 --> 00:12:04,360 HE DESCRIBES HIS AS A 327 00:12:04,360 --> 00:12:05,280 WHOLE-OF-GOVERNMENT APPROACH. 328 00:12:05,280 --> 00:12:07,000 YOU CAN SEE IN THE PHOTOGRAPH TO 329 00:12:07,000 --> 00:12:09,200 THE LEFT SEVERAL CABINET 330 00:12:09,200 --> 00:12:09,520 SECRETARIES. 331 00:12:09,520 --> 00:12:10,720 HE'S CONVENING A CANCER CABINET, 332 00:12:10,720 --> 00:12:12,880 THE NCI IS HONORED TO BE PART 333 00:12:12,880 --> 00:12:14,720 OF, TO BRING TOGETHER 334 00:12:14,720 --> 00:12:15,640 DEPARTMENTS AND AGENCIES TO HELP 335 00:12:15,640 --> 00:12:16,800 ESTABLISH AND MAKE PROGRESS ON 336 00:12:16,800 --> 00:12:19,080 THE GOALS OF ENDING CANCER AS WE 337 00:12:19,080 --> 00:12:24,040 KNOW IT, INCLUDING 19 AGENCIES 338 00:12:24,040 --> 00:12:34,840 SUCH AS HHS, DoD, CMS, CDC, 339 00:12:34,840 --> 00:12:36,400 EPA, VA AND OTHERS. 340 00:12:36,400 --> 00:12:42,880 IT'S CLEAR NCI WILL BE PRIMARILY 341 00:12:42,880 --> 00:12:46,040 RESPONSE BUT THIS IS BIGGER THAN 342 00:12:46,040 --> 00:12:47,480 RESEARCH FOR THE NATIONAL CANCER 343 00:12:47,480 --> 00:12:47,800 INSTITUTE. 344 00:12:47,800 --> 00:12:49,360 IT'S NOT JUST DEVELOPING NO 345 00:12:49,360 --> 00:12:51,400 TREATMENTS AND PREVENTION, IT'S 346 00:12:51,400 --> 00:12:53,040 ENSURING ACCESS AND IMPROVING 347 00:12:53,040 --> 00:12:54,320 HEALTH CARE DELIVERED WITHIN 348 00:12:54,320 --> 00:12:55,600 COMMUNITIES AND PROMOTING HEALTH 349 00:12:55,600 --> 00:12:55,840 EQUITY. 350 00:12:55,840 --> 00:12:57,680 WE'LL SEE A LOT OF NEW IDEAS 351 00:12:57,680 --> 00:12:58,920 COME OUT OF THE CANCER CABINET 352 00:12:58,920 --> 00:13:00,440 AND I'M EXCITED FOR THIS 353 00:13:00,440 --> 00:13:02,200 ANNOUNCEMENT AS WELL. 354 00:13:02,200 --> 00:13:03,200 NEXT SLIDE. 355 00:13:03,200 --> 00:13:05,200 I WANT TO REMIND EVERYONE WE'RE 356 00:13:05,200 --> 00:13:09,200 STILL VERY EXCITED ABOUT 357 00:13:09,200 --> 00:13:10,760 MOONSHOT, 1.0, THAT'S VERY MUCH 358 00:13:10,760 --> 00:13:12,800 A WORK IN PROGRESS, WHERE THE 359 00:13:12,800 --> 00:13:17,800 NCI IS PROUD OF THIS RESEARCH, 360 00:13:17,800 --> 00:13:19,800 CREATING 70 CONSORTIA, MORE THAN 361 00:13:19,800 --> 00:13:24,640 70, FUNDING MORE THAN 240 NEW 362 00:13:24,640 --> 00:13:26,400 RESEARCH PROJECTS, WORKING ON A 363 00:13:26,400 --> 00:13:28,200 VARIETY OF AREAS IN THE 364 00:13:28,200 --> 00:13:28,800 TRANSLATIONAL SPACE. 365 00:13:28,800 --> 00:13:33,560 YOU CAN SEE THE FUNDING FOR THAT 366 00:13:33,560 --> 00:13:34,800 INITIATIVE SUNSETS IN 2023, A 367 00:13:34,800 --> 00:13:37,400 GREAT TIME TO TALK ABOUT SUPER 368 00:13:37,400 --> 00:13:40,920 CHARGING THE MOONSHOT. 369 00:13:40,920 --> 00:13:42,280 NEXT SLIDE. 370 00:13:42,280 --> 00:13:44,320 AND SO WE HAVE THOUGHT A LOT 371 00:13:44,320 --> 00:13:45,000 WORKING WITH COLLEAGUES IN THE 372 00:13:45,000 --> 00:13:46,560 WHITE HOUSE ABOUT WHAT IT WOULD 373 00:13:46,560 --> 00:13:48,760 MEAN TO END CANCER AS WE KNOW 374 00:13:48,760 --> 00:13:49,400 IT. 375 00:13:49,400 --> 00:13:52,120 AND IF YOU WATCH THE EVENT, OR 376 00:13:52,120 --> 00:13:54,400 READ ABOUT IT AFTERWARD, YOU SAW 377 00:13:54,400 --> 00:13:57,240 HOW NEW GOALS ARE BEING 378 00:13:57,240 --> 00:13:58,360 PRESENTED, FURTHER REFINEMENT OF 379 00:13:58,360 --> 00:13:59,400 REALLY UNDERSTANDING HOW WE KNOW 380 00:13:59,400 --> 00:14:01,600 CANCER TODAY AND HOW WE CAN WORK 381 00:14:01,600 --> 00:14:02,800 TO TRANSFORM THAT REALITY. 382 00:14:02,800 --> 00:14:04,400 SO A FEW OF THESE DESCRIPTIONS 383 00:14:04,400 --> 00:14:06,240 ARE SHOWN, TO GIVE YOU A SENSE 384 00:14:06,240 --> 00:14:10,320 OF SOME AREAS BEING ENVISIONED, 385 00:14:10,320 --> 00:14:12,040 NOT EVERY PROMISING AVENUE IS 386 00:14:12,040 --> 00:14:13,120 CALLED OUT, BUT TAKEN TOGETHER 387 00:14:13,120 --> 00:14:14,440 THIS BEGINS TO PRESENT A PICTURE 388 00:14:14,440 --> 00:14:18,040 OF THE SCALE AND SCOPE OF THE 389 00:14:18,040 --> 00:14:18,720 VISION AND DIRECTIONS UNDERSTOOD 390 00:14:18,720 --> 00:14:20,400 TO BE IMPORTANT AND PROMISING. 391 00:14:20,400 --> 00:14:21,760 I MIGHT ARGUE THIS IS DIFFERENT 392 00:14:21,760 --> 00:14:23,960 FROM THE WAY WE OFTEN FRAME 393 00:14:23,960 --> 00:14:25,200 OPPORTUNITIES WITHIN THE 394 00:14:25,200 --> 00:14:26,360 SCIENTIFIC COMMUNITY SO I THINK 395 00:14:26,360 --> 00:14:29,000 WE'RE PRONE TO TALK ABOUT LIKE 396 00:14:29,000 --> 00:14:31,680 TARGETING RAS OR UNDERSTANDING 397 00:14:31,680 --> 00:14:32,360 TUMOR MICROENVIRONMENT OR 398 00:14:32,360 --> 00:14:33,560 ELUCIDATING THE INTERPLAY OF 399 00:14:33,560 --> 00:14:34,160 MULTIPLE TRANSCRIPTION FACTORS 400 00:14:34,160 --> 00:14:36,520 IN A CELL. 401 00:14:36,520 --> 00:14:37,400 THOSE ARE WORTHY GOALS, 402 00:14:37,400 --> 00:14:40,400 IMPORTANT WAY OF DOING SCIENCE, 403 00:14:40,400 --> 00:14:41,360 BUT WHAT WE'RE REALLY DOING HERE 404 00:14:41,360 --> 00:14:44,360 IS WHAT THE NEXT PHASE OF THE 405 00:14:44,360 --> 00:14:45,760 MOONSHOT IS DOING INTENTIONALLY, 406 00:14:45,760 --> 00:14:47,160 LOOKING AT WHAT CANCER IS TODAY 407 00:14:47,160 --> 00:14:49,200 AND HOW PATIENTS EXPERIENCE IT, 408 00:14:49,200 --> 00:14:51,720 AND HOW WE CAN CHANGE WHAT IS A 409 00:14:51,720 --> 00:14:52,800 TRAGIC DIAGNOSIS FOR MANY 410 00:14:52,800 --> 00:14:53,880 PATIENTS THAT AFFECTS THEIR 411 00:14:53,880 --> 00:14:58,240 LIVES DAY IN AND DAY OUT. 412 00:14:58,240 --> 00:15:02,000 AND SO THESE BEGIN TO REFLECT 413 00:15:02,000 --> 00:15:03,200 THINKING OF NCI AND WHITE HOUSE, 414 00:15:03,200 --> 00:15:06,440 MORE WORK TO COME IN THESE 415 00:15:06,440 --> 00:15:06,880 AREAS. 416 00:15:06,880 --> 00:15:08,520 SO ONE IMPORTANT WAY TO SORT OF 417 00:15:08,520 --> 00:15:10,160 TALK ABOUT CHANGING THE 418 00:15:10,160 --> 00:15:11,920 EXPERIENCE OF CANCER IS 419 00:15:11,920 --> 00:15:14,200 EXAMINING THIS THROUGH THE PRISM 420 00:15:14,200 --> 00:15:14,880 OF CANCER MORTALITY IN THE 421 00:15:14,880 --> 00:15:15,840 UNITED STATES. 422 00:15:15,840 --> 00:15:18,480 I TALKED ABOUT THIS A LOT BEFORE 423 00:15:18,480 --> 00:15:22,400 BUT I THINK IT CONTINUES TO BE A 424 00:15:22,400 --> 00:15:23,600 REALLY GOOD METRIC TO THINK 425 00:15:23,600 --> 00:15:25,800 ABOUT PROGRESS IN CANCER BECAUSE 426 00:15:25,800 --> 00:15:28,160 IT'S NOT BIASED BY LEAD TIME 427 00:15:28,160 --> 00:15:30,080 BIAS OR SCREENING BIAS. 428 00:15:30,080 --> 00:15:32,760 YOU KNOW, IT'S AN AREA, IT'S A 429 00:15:32,760 --> 00:15:34,200 METRIC WE COLLECT ANNUALLY, AND 430 00:15:34,200 --> 00:15:35,160 LOOK AT VERY CAREFULLY ALONG 431 00:15:35,160 --> 00:15:37,480 WITH THE CDC AND OTHER AGENCIES, 432 00:15:37,480 --> 00:15:40,000 AND SO I THINK IT IS A GREAT WAY 433 00:15:40,000 --> 00:15:41,720 TO TALK ABOUT WHAT CANCER 434 00:15:41,720 --> 00:15:44,320 PROGRESS MIGHT LOOK LIKE. 435 00:15:44,320 --> 00:15:48,320 SO YOU CAN SEE HERE DATA FROM 436 00:15:48,320 --> 00:15:52,400 2005 TO 2019, A VERY STRIKING 437 00:15:52,400 --> 00:15:53,800 DECLINE IN AGE-ADJUSTED CANCER 438 00:15:53,800 --> 00:15:54,560 MORTALITY ACROSS THE UNITED 439 00:15:54,560 --> 00:15:54,880 STATES. 440 00:15:54,880 --> 00:15:57,600 BUT YOU CAN ALSO NOTE THERE'S A 441 00:15:57,600 --> 00:15:59,680 LOT OF HETEROGENEITY EVEN 442 00:15:59,680 --> 00:16:00,680 PERSISTING TODAY, SOME STATES 443 00:16:00,680 --> 00:16:02,560 THAT HAVE HIGH RATES OF CANCER 444 00:16:02,560 --> 00:16:04,040 MORTALITY RELATIVE TO OTHER 445 00:16:04,040 --> 00:16:06,680 STATES THAT HAVE QUITE LOW 446 00:16:06,680 --> 00:16:07,520 RATES. 447 00:16:07,520 --> 00:16:08,560 WHILE THERE'S PROGRESS MADE 448 00:16:08,560 --> 00:16:10,000 ACROSS THE COUNTRY, THAT 449 00:16:10,000 --> 00:16:12,040 PROGRESS IS NOT EVEN. 450 00:16:12,040 --> 00:16:16,640 AND THIS BEGINS TO MAKE YOU 451 00:16:16,640 --> 00:16:18,120 HELP -- HELPS ONE UNDERSTAND THE 452 00:16:18,120 --> 00:16:20,280 COMPLEXITY OF THE METRIC LIKE 453 00:16:20,280 --> 00:16:22,000 CANCER MORTALITY AND CHALLENGES 454 00:16:22,000 --> 00:16:26,080 OF MAKING PROGRESS. 455 00:16:26,080 --> 00:16:29,080 I WANT TO THANK NDCCPS FOR 456 00:16:29,080 --> 00:16:32,400 HELPING ME ORGANIZE THESE DATA. 457 00:16:32,400 --> 00:16:35,160 THE PRESIDENT AND COLLEAGUES IN 458 00:16:35,160 --> 00:16:37,160 OSTP HAVE DECIDED CANCER 459 00:16:37,160 --> 00:16:38,320 MORTALITY GOAL IS THE RIGHT WAY 460 00:16:38,320 --> 00:16:38,720 TO THINK ABOUT IT. 461 00:16:38,720 --> 00:16:40,600 THIS IS ONE OF THE MAJOR 462 00:16:40,600 --> 00:16:41,400 ANNOUNCEMENTS LAST WEEK. 463 00:16:41,400 --> 00:16:43,160 THE PRESIDENT SET A GOAL TO 464 00:16:43,160 --> 00:16:45,120 REDUCE DEATH RATE FROM CANCER BY 465 00:16:45,120 --> 00:16:48,000 AT LEAST 50% OVER THE NEXT 25 466 00:16:48,000 --> 00:16:48,280 YEARS. 467 00:16:48,280 --> 00:16:49,760 SO REDUCTION OF AGE ADJUSTED 468 00:16:49,760 --> 00:16:54,200 MORTALITY FROM THE MOST RECENT 469 00:16:54,200 --> 00:16:56,000 RATE OF 146 PER 100,000 TO 73 470 00:16:56,000 --> 00:17:01,600 PER 100,000, PUTTING CANCER 471 00:17:01,600 --> 00:17:05,840 LOWER AS CAUSE OF MORTALITY 472 00:17:05,840 --> 00:17:06,400 NATIONALLY, REPRESENTING A 473 00:17:06,400 --> 00:17:08,000 CHANGE IN THE EXPERIENCE OF 474 00:17:08,000 --> 00:17:09,880 CANCER NATIONALLY AND WOULD BE A 475 00:17:09,880 --> 00:17:11,640 CRUCIAL STEP I WOULD THINK 476 00:17:11,640 --> 00:17:13,040 TOWARDS ENDING CANCER AS WE KNOW 477 00:17:13,040 --> 00:17:13,280 IT. 478 00:17:13,280 --> 00:17:15,440 I BELIEVE THIS IS A BOLD GOAL 479 00:17:15,440 --> 00:17:18,280 BUT I ALSO COMMEND THE PRESIDENT 480 00:17:18,280 --> 00:17:20,960 FOR ENUNCIATING AN ACHIEVABLE 481 00:17:20,960 --> 00:17:28,720 GOAL, NOT A PIE IN THE SKY 482 00:17:28,720 --> 00:17:32,200 WE-CAN'T-DO-THING, IT HAS 483 00:17:32,200 --> 00:17:34,960 DECLINED SUBSTANTIALLY SINCE 484 00:17:34,960 --> 00:17:36,240 1990s, WE CAN CONTINUE AND 485 00:17:36,240 --> 00:17:37,600 ACCELERATE TO MEET THE GOAL OF 486 00:17:37,600 --> 00:17:41,720 THE WHITE HOUSE. 487 00:17:41,720 --> 00:17:44,800 NEXT SLIDE AS I SAID, LOOKING 488 00:17:44,800 --> 00:17:46,000 BACK AT MORTALITY AGAIN, 489 00:17:46,000 --> 00:17:47,640 PROMOTING HEALTH EQUITY IS A BIG 490 00:17:47,640 --> 00:17:48,840 PART OF ENDING CANCER AS WE KNOW 491 00:17:48,840 --> 00:17:49,760 IT. 492 00:17:49,760 --> 00:17:51,640 I DON'T THINK THE PRESIDENT 493 00:17:51,640 --> 00:17:52,840 MEANT ENDING CANCER AS WE KNOW 494 00:17:52,840 --> 00:17:54,200 IT FOR SOME PEOPLE. 495 00:17:54,200 --> 00:17:55,800 HE WAS CLEAR HE WANTS ALL 496 00:17:55,800 --> 00:17:58,200 AMERICANS TO BENEFIT FROM THIS 497 00:17:58,200 --> 00:18:00,960 PROGRESS, AND SO ONE HAS TO TAKE 498 00:18:00,960 --> 00:18:02,480 AN HONEST LOOK ABOUT THE TOPIC 499 00:18:02,480 --> 00:18:05,160 OF HEALTH INEQUITIES IN OUR 500 00:18:05,160 --> 00:18:07,800 COUNTRY, AS INFLUENCED BY THINGS 501 00:18:07,800 --> 00:18:09,120 LIKE RURALITY, POVERTY, IN THIS 502 00:18:09,120 --> 00:18:11,200 CASE RACE AND ETHNICITY. 503 00:18:11,200 --> 00:18:12,600 I SHARE MORTALITY DATA, THEY 504 00:18:12,600 --> 00:18:17,680 WERE COMPLICATED WHEN YOU ADD IN 505 00:18:17,680 --> 00:18:19,400 GEOGRAPHY FOR ALL-COMERS, BUT BY 506 00:18:19,400 --> 00:18:23,040 RACE AND ETHNICITY THE STORY IS 507 00:18:23,040 --> 00:18:25,320 FURTHER COMPLICATED. 508 00:18:25,320 --> 00:18:28,000 NON-HISPANIC BLACK PATIENTS HAVE 509 00:18:28,000 --> 00:18:34,080 WORSE OUTCOMES, EVEN THOUGH 510 00:18:34,080 --> 00:18:35,600 THERE'S IMPROVEMENT. 511 00:18:35,600 --> 00:18:36,720 GEOGRAPHIC DISPARITY FOR 512 00:18:36,720 --> 00:18:44,000 AGGREGATE DATA AND DIFFERENT 513 00:18:44,000 --> 00:18:44,280 POPULATIONS. 514 00:18:44,280 --> 00:18:45,480 NON-HISPANIC AMERICAN 515 00:18:45,480 --> 00:18:47,640 INDIAN/ALASKA NATIVE, NOT 516 00:18:47,640 --> 00:18:50,400 HOMOGENUS, STARK DIFFERENCES 517 00:18:50,400 --> 00:18:59,800 DEPENDING ON GEOGRAPHY, AAIN 518 00:18:59,800 --> 00:19:04,040 LOOK GOOD, AND OTHER PLACES THEY 519 00:19:04,040 --> 00:19:05,920 ARE NOT. 520 00:19:05,920 --> 00:19:09,960 THINGS LIKE TOBACCO USE, ON 521 00:19:09,960 --> 00:19:11,800 FEBRUARY 5 NAVAJO NATION ENACTED 522 00:19:11,800 --> 00:19:14,520 FIRST BAN ON TRIBAL LAND, 523 00:19:14,520 --> 00:19:16,280 IMPORTANT IN TERMS OF CANCER 524 00:19:16,280 --> 00:19:17,600 THERE. 525 00:19:17,600 --> 00:19:19,120 TO ACHIEVE MORTALITY GOALS WE 526 00:19:19,120 --> 00:19:20,640 HAVE TO TACKLE INEQUITIES, HAVE 527 00:19:20,640 --> 00:19:22,880 TO MAKE PROGRESS FOR THOSE 528 00:19:22,880 --> 00:19:24,400 AMERICANS THAT HAVE THE WORST 529 00:19:24,400 --> 00:19:29,160 OUTCOMES BECAUSE OF LACK OF 530 00:19:29,160 --> 00:19:30,840 ACCESS OR STRUCTURAL RACISM OR 531 00:19:30,840 --> 00:19:34,160 POVERTY OR WEALTH OR EDUCATION 532 00:19:34,160 --> 00:19:36,800 OR THINGS THAT PROVIDE -- THAT 533 00:19:36,800 --> 00:19:39,520 CREATE THESE CANCER HEALTH 534 00:19:39,520 --> 00:19:40,280 DISPARITIES. 535 00:19:40,280 --> 00:19:40,720 NEXT SLIDE. 536 00:19:40,720 --> 00:19:41,920 ONE OF THE THINGS THE WHITE 537 00:19:41,920 --> 00:19:43,200 HOUSE HAS BEEN TALKING A LOT 538 00:19:43,200 --> 00:19:45,560 ABOUT AS A FOCUS OF THE NEXT 539 00:19:45,560 --> 00:19:47,200 CANCER MOONSHOT IS PREVENTION, 540 00:19:47,200 --> 00:19:48,800 SCREENING, EARLY DETECTION. 541 00:19:48,800 --> 00:19:51,200 THESE ARE IMPORTANT TOOLS FOR 542 00:19:51,200 --> 00:19:53,520 CONTROLLING CANCER AT THE 543 00:19:53,520 --> 00:19:55,160 POPULATION HEALTH LEVEL. 544 00:19:55,160 --> 00:19:56,880 AND TACKLING SOME OF THESE 545 00:19:56,880 --> 00:20:00,000 INEQUITIES I MENTIONED REQUIRES 546 00:20:00,000 --> 00:20:01,800 CLOSING GAPS IN SCREENING 547 00:20:01,800 --> 00:20:03,000 BEHAVIORS FOR EXAMPLE. 548 00:20:03,000 --> 00:20:06,400 THE PANEL TOOK THIS TOPIC ON AND 549 00:20:06,400 --> 00:20:08,200 HAS RELEASED THEIR REPORT 550 00:20:08,200 --> 00:20:09,960 SHINING A SPOTLIGHT IS A 551 00:20:09,960 --> 00:20:12,240 SCREENING, IDENTIFYING KEY GAPS, 552 00:20:12,240 --> 00:20:12,880 BARRIERS, PROVIDING 553 00:20:12,880 --> 00:20:13,520 RECOMMENDATIONS TO INCREASE 554 00:20:13,520 --> 00:20:15,720 EQUITABLE ACCESS. 555 00:20:15,720 --> 00:20:16,680 YOU SEE EDITH MITCHELL, JOHN 556 00:20:16,680 --> 00:20:18,760 WILLIAMS AND MYSELF AT THE 557 00:20:18,760 --> 00:20:21,200 MOONSHOT EVENT, TWO OF THE THREE 558 00:20:21,200 --> 00:20:23,680 MEMBERS OF THE PANEL. 559 00:20:23,680 --> 00:20:25,960 EARLY DETECTION TO REDUCE NEED 560 00:20:25,960 --> 00:20:26,640 FOR AGGRESSIVE THERAPIES THAT 561 00:20:26,640 --> 00:20:29,400 LOWER QUALITY OF LIFE AND 562 00:20:29,400 --> 00:20:30,400 INCREASE FINANCIAL BURDEN. 563 00:20:30,400 --> 00:20:32,760 AND THEIR REPORT CITES BARRIERS, 564 00:20:32,760 --> 00:20:35,520 IDENTIFIES LACK OF KNOWLEDGE OF 565 00:20:35,520 --> 00:20:37,600 GUIDELINES, LACK OF PROVIDER 566 00:20:37,600 --> 00:20:39,560 RECOMMENDATIONS, FEARS OR 567 00:20:39,560 --> 00:20:41,200 CONCERNS ABOUT MEDICAL 568 00:20:41,200 --> 00:20:42,720 PROCEDURES, DIFFICULTY 569 00:20:42,720 --> 00:20:43,400 NAVIGATING HEALTH SYSTEM, 570 00:20:43,400 --> 00:20:44,680 LOGISTICAL CHALLENGES INCLUDING 571 00:20:44,680 --> 00:20:46,520 LACK OF TRANSPORTATION AND 572 00:20:46,520 --> 00:20:47,520 PARKING, LACK OF ACCESS TO 573 00:20:47,520 --> 00:20:48,800 MEDICAL SERVICES. 574 00:20:48,800 --> 00:20:50,000 THE REPORT MAKES RECOMMENDATIONS 575 00:20:50,000 --> 00:20:51,360 ON HOW TO HELP ALL AMERICANS 576 00:20:51,360 --> 00:20:52,440 BETTER UNDERSTAND WHEN AND HOW 577 00:20:52,440 --> 00:20:54,280 THEY SHOULD BE SCREENED AND HOW 578 00:20:54,280 --> 00:20:56,000 TO IMPROVE ACCESS TO CANCER 579 00:20:56,000 --> 00:20:58,080 SCREENING THROUGH COMMUNITY 580 00:20:58,080 --> 00:21:00,600 ORIENTED OUTREACH AND EXPANSION 581 00:21:00,600 --> 00:21:02,280 OF SELF-SAMPLING TO SCREENING 582 00:21:02,280 --> 00:21:05,320 FOR CERVICAL AND COLON CANCER. 583 00:21:05,320 --> 00:21:06,200 IT RECOMMENDS HEALTH CARE 584 00:21:06,200 --> 00:21:07,480 SYSTEMS SET UP SYSTEMS THAT 585 00:21:07,480 --> 00:21:11,200 ALLOW ALL MECHANICS -- MEMBERS 586 00:21:11,200 --> 00:21:14,280 TO SUPPORT CANCER SCREENING AND 587 00:21:14,280 --> 00:21:16,040 MAKE IT A PRIORITY, PARTICULARLY 588 00:21:16,040 --> 00:21:19,560 GIVEN THE LAST TWO YEARS OF 589 00:21:19,560 --> 00:21:21,800 PANDEMIC THAT WE'VE HAD WITH 590 00:21:21,800 --> 00:21:22,840 ERRATIC EFFECT ON CANCER 591 00:21:22,840 --> 00:21:25,480 SCREENING. 592 00:21:25,480 --> 00:21:25,880 NEXT SLIGHT. 593 00:21:25,880 --> 00:21:27,200 NEXT SLIDE. 594 00:21:27,200 --> 00:21:30,160 HERE IS THE PLUMMET IN TERMS OF 595 00:21:30,160 --> 00:21:31,360 SCREENING RATES THAT OCCURRED 596 00:21:31,360 --> 00:21:35,000 EARLY IN THE PANDEMIC AND REALLY 597 00:21:35,000 --> 00:21:35,520 HAVE NOT RECOVERED. 598 00:21:35,520 --> 00:21:37,040 AND YOU SEE THE PRESIDENT'S CALL 599 00:21:37,040 --> 00:21:39,680 TO ACTION IN THIS AREA, NOTING 600 00:21:39,680 --> 00:21:42,160 OVER THE PANDEMIC PERIOD WE 601 00:21:42,160 --> 00:21:43,480 MISSED MORE THAN 9 MILLION 602 00:21:43,480 --> 00:21:45,040 SCREENINGS FOR CANCER, HAVE TO 603 00:21:45,040 --> 00:21:48,880 GET THOSE BACK ON TRACK FOR 604 00:21:48,880 --> 00:21:52,000 BREAST CANCER, COLON CANCER, 605 00:21:52,000 --> 00:21:56,720 CERVICAL, LUNG CANCER. 606 00:21:56,720 --> 00:21:57,520 IN SOME ASPECTED UNDERUTILIZED 607 00:21:57,520 --> 00:21:58,480 PRIOR TO THE PANDEMIC. 608 00:21:58,480 --> 00:22:00,640 WE NEED TO RECOVER AND INCREASE 609 00:22:00,640 --> 00:22:02,360 WHAT WE WERE DOING FOR LUNG 610 00:22:02,360 --> 00:22:03,320 CANCER SCREENING FOR INSTANCE. 611 00:22:03,320 --> 00:22:04,600 THE PRESIDENT CALLED FOR 612 00:22:04,600 --> 00:22:07,720 ENSURING EVERYONE IN THE U.S. 613 00:22:07,720 --> 00:22:08,960 EQUITABLY BENEFITS FROM 614 00:22:08,960 --> 00:22:10,240 SCREENING AT HOME, MOBILE 615 00:22:10,240 --> 00:22:11,680 SCREENING IN COMMUNITIES WITHOUT 616 00:22:11,680 --> 00:22:13,120 ACCESS TO CLINIC, COMMUNITY 617 00:22:13,120 --> 00:22:14,840 HEALTH NETWORKS, OTHER IMPORTANT 618 00:22:14,840 --> 00:22:16,520 WAYS TO REDUCE BARRIERS TO 619 00:22:16,520 --> 00:22:17,200 SCREENING. 620 00:22:17,200 --> 00:22:18,680 NCI WILL WORK WITH DESIGNATED 621 00:22:18,680 --> 00:22:20,400 CANCER CENTERS AND OTHER 622 00:22:20,400 --> 00:22:22,600 NETWORKS TO MAKE CLEAR THAT 623 00:22:22,600 --> 00:22:24,880 CANCER SCREENING IS A NATIONAL 624 00:22:24,880 --> 00:22:25,560 PRIORITY TO AFFECT CANCER 625 00:22:25,560 --> 00:22:28,080 MORTALITY AT THE POPULATION 626 00:22:28,080 --> 00:22:28,280 LEVEL. 627 00:22:28,280 --> 00:22:31,680 NCI WILL COLLECT DATA TO 628 00:22:31,680 --> 00:22:33,200 UNDERSTAND THE NEED AND 629 00:22:33,200 --> 00:22:34,320 DISSEMINATE DATA IN PARTNERSHIP 630 00:22:34,320 --> 00:22:36,880 WITH OTHER PARTS OF GOVERNMENT 631 00:22:36,880 --> 00:22:39,120 LIKE CMS, HRSA, CDC. 632 00:22:39,120 --> 00:22:40,440 NEXT SLIDE. 633 00:22:40,440 --> 00:22:41,240 ONE AREA OF INTEREST ACROSS THE 634 00:22:41,240 --> 00:22:42,200 FEDERAL GOVERNMENT CONTINUES TO 635 00:22:42,200 --> 00:22:46,000 BE THE TOPIC OF MULTI-CANCER 636 00:22:46,000 --> 00:22:46,400 DETECTION TESTS. 637 00:22:46,400 --> 00:22:48,320 THESE ARE THESE TESTS THAT HAVE 638 00:22:48,320 --> 00:22:52,000 THE POTENTIAL TO DETECT MANY 639 00:22:52,000 --> 00:22:54,000 CANCERS SIMULTANEOUSLY IN A 640 00:22:54,000 --> 00:22:55,400 BLOOD-BASED ASSAY IN AN 641 00:22:55,400 --> 00:22:57,200 OTHERWISE HEALTHY INDIVIDUAL. 642 00:22:57,200 --> 00:22:59,080 AND IF THE TESTS WORK, TO THE 643 00:22:59,080 --> 00:23:01,280 EXTENT WE WOULD HOPE, WE HAVE 644 00:23:01,280 --> 00:23:02,680 POTENTIAL TO REDUCE CANCER 645 00:23:02,680 --> 00:23:02,960 MORTALITY. 646 00:23:02,960 --> 00:23:04,040 THE WHITE HOUSE ANNOUNCED 647 00:23:04,040 --> 00:23:06,280 FEDERAL AGENCIES LED BY NCI WILL 648 00:23:06,280 --> 00:23:09,360 DEVELOP A FOCUS PROGRAM TO STUDY 649 00:23:09,360 --> 00:23:10,800 AND EVALUATE MULTI-CANCER 650 00:23:10,800 --> 00:23:12,840 DETECTION TESTS. 651 00:23:12,840 --> 00:23:13,920 BUT THESE TESTS REQUIRE RIGOROUS 652 00:23:13,920 --> 00:23:15,480 TESTING AND I DON'T THINK WE CAN 653 00:23:15,480 --> 00:23:18,120 ASSUME THAT THESE THINGS WILL 654 00:23:18,120 --> 00:23:20,480 NECESSARILY WORK. 655 00:23:20,480 --> 00:23:23,040 SCREENING AND EARLY DETECTION 656 00:23:23,040 --> 00:23:24,720 HAS POTENTIAL FOR OVERDIAGNOSIS, 657 00:23:24,720 --> 00:23:25,440 OVERTREATMENT, CAN THEREFORE 658 00:23:25,440 --> 00:23:26,040 CAUSE HARM. 659 00:23:26,040 --> 00:23:28,200 ONE STEP THE NCI HAS MADE IS 660 00:23:28,200 --> 00:23:31,880 DROP THE E. 661 00:23:31,880 --> 00:23:36,440 IT'S USUALLY MCED, DOUG LOWY 662 00:23:36,440 --> 00:23:40,600 POINTED OUT EARLY CANCER IS NOT 663 00:23:40,600 --> 00:23:45,120 PROVEN YET AND CONVINCED US TO 664 00:23:45,120 --> 00:23:46,160 CALL IT MULTI-CANCER DETECTION 665 00:23:46,160 --> 00:23:46,360 TESTS. 666 00:23:46,360 --> 00:23:48,600 TO HELP US THINK ABOUT THIS 667 00:23:48,600 --> 00:23:50,240 PORTFOLIO, WE TALKED ABOUT THIS 668 00:23:50,240 --> 00:23:53,000 BEFORE, IT CONTINUES AN AREA OF 669 00:23:53,000 --> 00:23:57,360 MAJOR INTEREST. 670 00:23:57,360 --> 00:23:58,200 NEXT SLIDE. 671 00:23:58,200 --> 00:24:00,120 WE CONTINUE -- I'LL SHOW WORK 672 00:24:00,120 --> 00:24:01,600 FROM THE INTRAMURAL PROGRAM THAT 673 00:24:01,600 --> 00:24:04,080 WE THINK COULD BE IMPORTANT IN 674 00:24:04,080 --> 00:24:05,400 TERMS OF THE PRESIDENT'S GOALS 675 00:24:05,400 --> 00:24:07,520 OF ENDING CANCER AS WE KNOW IT. 676 00:24:07,520 --> 00:24:10,000 WITH REGARD TO PREVENTION 677 00:24:10,000 --> 00:24:13,320 THERE'S AN INTERESTING STUDY 678 00:24:13,320 --> 00:24:15,280 CO-AUTHORED BY DCCPS, DCEG, CDC, 679 00:24:15,280 --> 00:24:18,000 IT TALKS ABOUT POTENTIAL PUBLIC 680 00:24:18,000 --> 00:24:20,000 HEALTH BENEFITS OF CHANGING 681 00:24:20,000 --> 00:24:28,920 DAILY PHYSICAL ACTIVITY, US 682 00:24:28,920 --> 00:24:35,800 ACCELEROMETER INFO, DATA FROM 683 00:24:35,800 --> 00:24:38,720 NHANES OF 4800 ADULTS 40-85, 684 00:24:38,720 --> 00:24:39,320 INCREASED ACTIVITY ASSOCIATED 685 00:24:39,320 --> 00:24:41,400 WITH DECREASE IN NUMBER OF 686 00:24:41,400 --> 00:24:43,360 DEATHS PER YEAR. 687 00:24:43,360 --> 00:24:46,560 ONE WEEK OF MONITORING MAY NOT 688 00:24:46,560 --> 00:24:49,040 REFLECT CHANGES OVER TIME, CAN'T 689 00:24:49,040 --> 00:24:50,240 ESTABLISH CAUSALITY. 690 00:24:50,240 --> 00:24:50,920 MORE RESEARCH IS NEEDED, WE 691 00:24:50,920 --> 00:24:56,120 THINK THIS IS AN IMPORTANT AND 692 00:24:56,120 --> 00:24:56,880 POTENTIALLY ACTIONABLE RESULT. 693 00:24:56,880 --> 00:24:58,640 WE BELIEVE ACTIVITY IN PART 694 00:24:58,640 --> 00:24:59,600 AFFECTS OBESITY, WHICH IS A 695 00:24:59,600 --> 00:25:00,960 GROWING PROBLEM IN THE UNITED 696 00:25:00,960 --> 00:25:03,240 STATES, AND IT'S BECOME ONE OF 697 00:25:03,240 --> 00:25:04,000 THE LEADING MODIFIABLE BEHAVIORS 698 00:25:04,000 --> 00:25:06,400 IN TERMS OF CANCER RISK, 699 00:25:06,400 --> 00:25:08,280 THEREFORE ACTIVITY MAY PLAY A 700 00:25:08,280 --> 00:25:14,400 ROLE IN REDUCING THE MORTALITY, 701 00:25:14,400 --> 00:25:16,000 POPULATION LEVEL MORTALITY 702 00:25:16,000 --> 00:25:17,640 ASSOCIATED WITH CANCER. 703 00:25:17,640 --> 00:25:18,840 SMALL AMOUNTS OF ADDITIONAL 704 00:25:18,840 --> 00:25:20,720 ACTIVITY CAN REALLY MAKE A 705 00:25:20,720 --> 00:25:21,000 DIFFERENCE. 706 00:25:21,000 --> 00:25:21,680 NEXT SLIDE. 707 00:25:21,680 --> 00:25:23,880 TO END CANCER WE'LL NEED TO 708 00:25:23,880 --> 00:25:24,880 DEVELOP NEW THERAPEUTICS. 709 00:25:24,880 --> 00:25:27,360 SO THERE'S A LOT GOING ON IN ANY 710 00:25:27,360 --> 00:25:28,280 AREA IN CANCER RESEARCH AND I 711 00:25:28,280 --> 00:25:30,440 THINK THIS IS ONE OF THE 712 00:25:30,440 --> 00:25:32,400 IMPORTANT REASONS WE ALSO HAVE 713 00:25:32,400 --> 00:25:36,440 SUCH A PASSION, STRONG SUPPORT 714 00:25:36,440 --> 00:25:38,400 OF THE NCI FOR INVESTIGATOR 715 00:25:38,400 --> 00:25:40,400 INITIATED BASIC CANCER BIOLOGY, 716 00:25:40,400 --> 00:25:42,800 THE SUBSTRATE FOR NEW 717 00:25:42,800 --> 00:25:43,120 DISCOVERIES. 718 00:25:43,120 --> 00:25:45,640 AS YOU SEE EVERY WEEK, THERE'S 719 00:25:45,640 --> 00:25:47,960 NEW EXCITING IDEAS IN TERMS OF 720 00:25:47,960 --> 00:25:52,080 CANCER THERAPY. 721 00:25:52,080 --> 00:25:59,160 STEVE ROSENBERG ARE TWO PAPERS 722 00:25:59,160 --> 00:26:01,360 OUT, TUMOR INFILTRATES, THIS WAS 723 00:26:01,360 --> 00:26:02,560 PATIENTS WITH REFRACTORY BREAST 724 00:26:02,560 --> 00:26:04,080 CANCER THAT FAILED MULTIPLE 725 00:26:04,080 --> 00:26:05,280 PRIOR TREATMENTS, STILL A VERY 726 00:26:05,280 --> 00:26:08,680 IMPORTANT CAUSE OF CANCER DEATH, 727 00:26:08,680 --> 00:26:12,000 STEVE USES THESE PERSONALIZED 728 00:26:12,000 --> 00:26:13,240 TUMOR INFILTRATING LYMPHOCYTES 729 00:26:13,240 --> 00:26:15,440 TO TREAT THESE PATIENTS WITH 730 00:26:15,440 --> 00:26:19,520 METASTATIC BREAST CANCER. 731 00:26:19,520 --> 00:26:23,000 THE RESULTS, TRIAL IN THE 732 00:26:23,000 --> 00:26:23,720 CLINICAL CENTER, RESEARCHERS 733 00:26:23,720 --> 00:26:25,720 ADVOCATE WHOLE GENOME SEQUENCING 734 00:26:25,720 --> 00:26:28,040 TO IDENTIFY MUTATIONS FOR 42 735 00:26:28,040 --> 00:26:29,000 WOMEN. 736 00:26:29,000 --> 00:26:31,800 THEY ISOLATED TILLs FROM TUMOR 737 00:26:31,800 --> 00:26:36,080 SAMPLES, TEST THE REACTIVITY 738 00:26:36,080 --> 00:26:36,680 AGAINST NEOANTIGENS AND SHOWED 739 00:26:36,680 --> 00:26:38,840 MORE THAN 2/3 OF THE WOMEN, 28 740 00:26:38,840 --> 00:26:41,040 OUT OF 41 WITH METASTATIC BREAST 741 00:26:41,040 --> 00:26:43,800 CABER IS HAD TILs THAT 742 00:26:43,800 --> 00:26:44,800 RECOGNIZED ONE NEOANTIGEN AND 743 00:26:44,800 --> 00:26:46,040 GENERATED EVIDENCE OF IMMUNE 744 00:26:46,040 --> 00:26:46,320 REACTION. 745 00:26:46,320 --> 00:26:48,400 SO FOR SIX WOMEN THEY WERE ABLE 746 00:26:48,400 --> 00:26:49,800 TO REINFUSE TILs THEY HAD 747 00:26:49,800 --> 00:26:51,120 GROWN IN THE LAB, AND RETURN 748 00:26:51,120 --> 00:26:53,200 THEM TO THE PATIENT WITH 749 00:26:53,200 --> 00:26:56,760 TREATMENT FOR THE CHECKPOINT 750 00:26:56,760 --> 00:26:59,480 INHIBITOR TO PREVENT TIL 751 00:26:59,480 --> 00:27:00,440 EXHAUSTIONS, TUMOR SHRANK IN 752 00:27:00,440 --> 00:27:02,760 THREE OUT OF SIX, A PROMISING 753 00:27:02,760 --> 00:27:06,160 SET OF STUDIES IN A HIGHLY 754 00:27:06,160 --> 00:27:07,680 TREATED POPULATION. 755 00:27:07,680 --> 00:27:09,760 AND SHOWS POWER OF FINDING 756 00:27:09,760 --> 00:27:13,920 ANTI-CANCER IMMUNE CELLS, EVEN 757 00:27:13,920 --> 00:27:15,120 IN PEOPLE WHO WOULDN'T HAVE 758 00:27:15,120 --> 00:27:19,480 THOUGHT WOULD BE GOOD CANDIDATES 759 00:27:19,480 --> 00:27:21,480 FOR IMMUNO-ONCOLOGY. 760 00:27:21,480 --> 00:27:23,720 SECOND POWER IN "SCIENCE," 761 00:27:23,720 --> 00:27:25,040 EXPRESSION PROFILES OF 762 00:27:25,040 --> 00:27:30,200 TUMOR-SPECIFIC TILs, SO THEY 763 00:27:30,200 --> 00:27:32,600 FOUND TCR CLONOTYPES, SINGLE 764 00:27:32,600 --> 00:27:38,840 CELL TRANSCRIPTOME 765 00:27:38,840 --> 00:27:39,360 TRANSCRIPTOMIC ANALYSIS, 766 00:27:39,360 --> 00:27:41,680 IDENTIFYING THOSE CAPABLE OF 767 00:27:41,680 --> 00:27:42,800 INDUCING ANTI-TUMOR RESPONSE AND 768 00:27:42,800 --> 00:27:45,000 MAKES THEIR PRODUCTION AND 769 00:27:45,000 --> 00:27:47,360 SELECTION MUCH SIMPLER, AN 770 00:27:47,360 --> 00:27:48,720 IMPORTANT STEP TO BRING TILs 771 00:27:48,720 --> 00:27:49,800 TO MORE GENERAL USAGE. 772 00:27:49,800 --> 00:27:52,960 RIGHT NOW THIS IS HIGHLY 773 00:27:52,960 --> 00:27:55,160 COMPLICATED SCIENCE DONE IN THE 774 00:27:55,160 --> 00:27:56,720 INTRAMURAL PROGRAM AT NCI BUT IF 775 00:27:56,720 --> 00:27:58,960 THIS IS GOING TO BECOME SCALABLE 776 00:27:58,960 --> 00:28:00,600 THESE ARE IMPORTANT RESEARCH 777 00:28:00,600 --> 00:28:03,000 QUESTIONS TO ADDRESS. 778 00:28:03,000 --> 00:28:04,280 NEXT SLIDE. 779 00:28:04,280 --> 00:28:05,920 EFFORTS TO END CANCER MUST ALSO 780 00:28:05,920 --> 00:28:07,880 ACCOUNT FOR DIFFERENCES IN 781 00:28:07,880 --> 00:28:09,400 SPECIFIC POPULATIONS, FROM 782 00:28:09,400 --> 00:28:12,000 HEALTH DISPARITIES PERSPECTIVE 783 00:28:12,000 --> 00:28:13,360 AND POPULATION PERSPECTIVE. 784 00:28:13,360 --> 00:28:16,880 THE NCI IS COMMITTED TO 785 00:28:16,880 --> 00:28:17,560 UNRAVELING CHILDHOOD CANCER, 786 00:28:17,560 --> 00:28:18,960 CHILDREN ARE NOT JUST LITTLE 787 00:28:18,960 --> 00:28:21,600 ADULTS, EFFORTS IN THE CHILDHOOD 788 00:28:21,600 --> 00:28:23,560 CANCER DATA INITIATIVE 789 00:28:23,560 --> 00:28:24,000 DEMONSTRATED UNIQUE 790 00:28:24,000 --> 00:28:25,080 OPPORTUNITIES AND SIGNIFICANT 791 00:28:25,080 --> 00:28:26,480 CHALLENGES THAT REMAIN BEFORE 792 00:28:26,480 --> 00:28:26,800 US. 793 00:28:26,800 --> 00:28:29,360 AND I FELT LIKE I NEEDED MORE 794 00:28:29,360 --> 00:28:30,320 HELP THINKING THROUGH THESE 795 00:28:30,320 --> 00:28:33,040 PEDIATRIC CANCER ISSUES. 796 00:28:33,040 --> 00:28:41,520 TO END I'M PLEASED TO ANNOUNCE 797 00:28:41,520 --> 00:28:43,920 DR. WILDMANN WILL ASSUME A 798 00:28:43,920 --> 00:28:45,880 LEADERSHIP ROLE AND GIVE ADVICE 799 00:28:45,880 --> 00:28:50,280 TO NCI DIRECTOR. 800 00:28:50,280 --> 00:28:51,920 SHE'S A PRACTICING PEDIATRIC 801 00:28:51,920 --> 00:28:54,080 ONCOLOGIST, FAMILIAR WITH NCI'S 802 00:28:54,080 --> 00:28:55,600 ENTIRE CHILDHOOD CANCER RESEARCH 803 00:28:55,600 --> 00:28:57,240 PORTFOLIO AND WILL BRING 804 00:28:57,240 --> 00:28:58,880 VALUABLE CLINICAL AND SCIENTIFIC 805 00:28:58,880 --> 00:29:00,320 PERSPECTIVES ON RESEARCH GAPS 806 00:29:00,320 --> 00:29:01,880 AND GAPS IN TREATMENT. 807 00:29:01,880 --> 00:29:03,080 SHE WILL CONTINUE HER POSITION 808 00:29:03,080 --> 00:29:08,440 AS HEAD OF THE PHARMACOLOGY AND 809 00:29:08,440 --> 00:29:09,120 EXPERIMENTAL THERAPEUTICS 810 00:29:09,120 --> 00:29:10,160 SECTION, CHIEF OF PEDIATRIC 811 00:29:10,160 --> 00:29:13,680 ONCOLOGY BRANCH, IN ADDITION 812 00:29:13,680 --> 00:29:18,280 GIVING ADVICE, PIONEERING 813 00:29:18,280 --> 00:29:19,640 RESEARCH ON NEUROFIBROMATOSIS, 814 00:29:19,640 --> 00:29:21,280 RESULTING IN MEDICAL THERAPY FOR 815 00:29:21,280 --> 00:29:23,920 CHILDREN LAST YEAR, VERY 816 00:29:23,920 --> 00:29:26,640 EXCITING DEVELOPMENT ON A 817 00:29:26,640 --> 00:29:28,400 CONGENITAL CANCER SYNDROME 818 00:29:28,400 --> 00:29:28,960 DISCOVERED DECADES AGO BY 819 00:29:28,960 --> 00:29:29,600 FRANCIS COLLINS. 820 00:29:29,600 --> 00:29:36,200 HER WORK IN THIS AREA LED TO HER 821 00:29:36,200 --> 00:29:38,360 NOMINATION FOR A SAMI, SERVICE 822 00:29:38,360 --> 00:29:40,000 TO AMERICA AWARD, COMES AT A 823 00:29:40,000 --> 00:29:41,080 GREAT TIME, A TIME OF GREAT 824 00:29:41,080 --> 00:29:43,160 PROGRESS AND OPPORTUNITY IN 825 00:29:43,160 --> 00:29:44,640 CHILDHOOD CANCER RESEARCH, SO 826 00:29:44,640 --> 00:29:46,800 WE'RE EXCITED ABOUT HAVING HER 827 00:29:46,800 --> 00:29:49,720 WISDOM TO HELP NOW. 828 00:29:49,720 --> 00:29:50,160 NEXT SLIDE. 829 00:29:50,160 --> 00:29:52,240 I WANT TO BE SURE TO EMPHASIZE 830 00:29:52,240 --> 00:29:54,200 ESPECIALLY IN LIGHT OF EVENTS 831 00:29:54,200 --> 00:29:58,080 THIS WEEK ONE THING THE NCI IS 832 00:29:58,080 --> 00:30:00,040 ABOUT, WE'RE UNEQUIVOCALLY 833 00:30:00,040 --> 00:30:02,160 COMMITTED TO ENSURING CIVILITY, 834 00:30:02,160 --> 00:30:03,280 KINDNESS, IN OUR WORKPLACE, CORE 835 00:30:03,280 --> 00:30:05,000 VALUES AT THE NCI AND NIH. 836 00:30:05,000 --> 00:30:06,280 WE BELIEVE THIS IS HOW PEOPLE DO 837 00:30:06,280 --> 00:30:06,960 THEIR BEST WORK. 838 00:30:06,960 --> 00:30:09,600 THE NCI IS NOT A PLACE WHERE WE 839 00:30:09,600 --> 00:30:10,680 TOLERATE BULLYING OR HARASSMENT 840 00:30:10,680 --> 00:30:12,160 OF ANY KIND. 841 00:30:12,160 --> 00:30:15,720 NIH POLICY IS CLEAR. 842 00:30:15,720 --> 00:30:20,040 AND IS SHOWN IN A STATEMENT FROM 843 00:30:20,040 --> 00:30:22,000 LARRY TABAK, IT WILL NOT BE 844 00:30:22,000 --> 00:30:23,600 TOLERATED, TIMELY ACTION WILL BE 845 00:30:23,600 --> 00:30:24,240 TAKEN AGAINST ANY INDIVIDUAL 846 00:30:24,240 --> 00:30:26,480 FOUND TO BE IN VIOLATION OF THIS 847 00:30:26,480 --> 00:30:26,920 POLICY. 848 00:30:26,920 --> 00:30:29,760 AT NCI WE HAVE A WORKPLACE 849 00:30:29,760 --> 00:30:30,920 CIVILITY AND ANTI-HARASSMENT 850 00:30:30,920 --> 00:30:32,920 PROGRAM COORDINATED BY A 851 00:30:32,920 --> 00:30:34,120 WORKPLACE CIVILITY COMMITTEE 852 00:30:34,120 --> 00:30:35,560 MADE OF SENIOR REPRESENTATIVES 853 00:30:35,560 --> 00:30:40,480 ACROSS THE NCI DIVISION AND 854 00:30:40,480 --> 00:30:41,160 CENTERS, COMMUNICATED CLEAR 855 00:30:41,160 --> 00:30:44,320 POLICIES AND PROVIDED TOOL KITS 856 00:30:44,320 --> 00:30:46,280 AND TRAINING, INCORPORATED 857 00:30:46,280 --> 00:30:48,080 ANTI-HARASSMENT INTO ONBOARDING 858 00:30:48,080 --> 00:30:49,800 AND EMPLOYEE PERFORMANCE 859 00:30:49,800 --> 00:30:50,080 EVALUATIONS. 860 00:30:50,080 --> 00:30:51,200 WE HAVE CHANNELS ACCESSIBLE FOR 861 00:30:51,200 --> 00:30:51,800 ANYONE WHO EXPERIENCES 862 00:30:51,800 --> 00:30:54,320 HARASSMENT TO REPORT IT SAFELY 863 00:30:54,320 --> 00:30:56,280 AND DISCREETLY WITHOUT FEAR OF 864 00:30:56,280 --> 00:30:57,040 RETALIATION. 865 00:30:57,040 --> 00:30:58,040 WE TAKE TIMELY AND APPROPRIATE 866 00:30:58,040 --> 00:31:00,800 ACTION TO RESPOND TO ALL REPORTS 867 00:31:00,800 --> 00:31:03,280 AND WE TAKE THIS COMMITMENT 868 00:31:03,280 --> 00:31:04,880 SERIOUSLY, BELIEVING DOING SO IS 869 00:31:04,880 --> 00:31:07,440 ESSENTIALLY TO FULFILLING OUR 870 00:31:07,440 --> 00:31:09,320 GOAL TO ENABLE ALL STAFF TO 871 00:31:09,320 --> 00:31:12,160 BRING THEIR BEST SELFS TO REACH 872 00:31:12,160 --> 00:31:14,080 THEIR POTENTIAL AND CONTRIBUTE 873 00:31:14,080 --> 00:31:16,640 TO OUR MEMBER TO REDUCE CANCER'S 874 00:31:16,640 --> 00:31:16,880 BURDEN. 875 00:31:16,880 --> 00:31:17,200 NEXT SLIDE. 876 00:31:17,200 --> 00:31:19,400 I'D LIKE TO CLOSE WITH MORE 877 00:31:19,400 --> 00:31:21,360 REFLECTION ON RECENT EVENTS AS I 878 00:31:21,360 --> 00:31:22,840 HAVE SAID, I'VE BEEN SO 879 00:31:22,840 --> 00:31:26,480 IMPRESSED BY THE FIRST LADY'S 880 00:31:26,480 --> 00:31:28,000 GRASP OF CANCER RESEARCH, GRACE 881 00:31:28,000 --> 00:31:31,800 AND SINCERITY. 882 00:31:31,800 --> 00:31:32,800 LAST WEEK WE ECHOED THAT WE'RE 883 00:31:32,800 --> 00:31:35,640 IN A GOLDEN AGE OF CANCER 884 00:31:35,640 --> 00:31:36,560 RESEARCH, SPEAKING VOLUMES. 885 00:31:36,560 --> 00:31:38,200 SHE AND THE PRESIDENT ARE FIRED 886 00:31:38,200 --> 00:31:40,920 UP ABOUT THE NEED TO MAKE 887 00:31:40,920 --> 00:31:41,800 PROGRESS IN KIDS CANCER, THEY 888 00:31:41,800 --> 00:31:45,000 BELIEVE THE TIME IS NOW TO MAKE 889 00:31:45,000 --> 00:31:46,800 THAT PROGRESS AND SUCCEED. 890 00:31:46,800 --> 00:31:49,760 IT'S HARD NOT TO BE INSPIRED BY 891 00:31:49,760 --> 00:31:49,960 THAT. 892 00:31:49,960 --> 00:31:53,600 I FOUND THIS SO INVIGORATING AND 893 00:31:53,600 --> 00:31:55,840 IT WAS SO GOOD TO GALVANIZE ALL 894 00:31:55,840 --> 00:31:57,160 OF US INTERESTED IN PROGRESS FOR 895 00:31:57,160 --> 00:31:57,800 OUR PATIENTS. 896 00:31:57,800 --> 00:31:59,680 NEXT SLIDE. 897 00:31:59,680 --> 00:32:00,200 ALSO AT THAT EVENT VICE 898 00:32:00,200 --> 00:32:01,760 PRESIDENT HARRIS SPOKE ABOUT HER 899 00:32:01,760 --> 00:32:04,200 MOTHER'S WORK AS A CANCER 900 00:32:04,200 --> 00:32:07,880 RESEARCHER, HER MOTHER'S DEATH 901 00:32:07,880 --> 00:32:09,200 DUE TO COLON CANCER AND YOU 902 00:32:09,200 --> 00:32:11,040 COULD HEAR HER RESPECT AND LOVE 903 00:32:11,040 --> 00:32:13,600 FOR HER MOTHER AND PASSION AND 904 00:32:13,600 --> 00:32:15,200 COMMITMENT TO MAKING PROGRESS 905 00:32:15,200 --> 00:32:16,520 AGAINST CANCER, SHE SAID THIS 906 00:32:16,520 --> 00:32:20,560 FOCUS ON THE CANCER MOONSHOT 907 00:32:20,560 --> 00:32:22,000 DEMONSTRATES WHO WE ARE, I 908 00:32:22,000 --> 00:32:23,200 QUOTE, IN AMERICA WE NOT ONLY 909 00:32:23,200 --> 00:32:24,040 DREAM, WE DO. 910 00:32:24,040 --> 00:32:26,000 WE NOT ONLY SEE WHAT CAN BE, WE 911 00:32:26,000 --> 00:32:28,440 SEE WHERE WE WANT TO GO IN A WAY 912 00:32:28,440 --> 00:32:30,520 WE CAN REACH FOR THE MOON AND 913 00:32:30,520 --> 00:32:31,920 PLANT OUR FLAG ON IT. 914 00:32:31,920 --> 00:32:34,240 A GREAT REMINDER OF THE POINT OF 915 00:32:34,240 --> 00:32:35,800 THE MOONSHOT, WHY THE PRESIDENT 916 00:32:35,800 --> 00:32:37,840 AND WHITE HOUSE LIKE THIS 917 00:32:37,840 --> 00:32:39,720 METAPHOR, TALKS ABOUT 918 00:32:39,720 --> 00:32:41,000 GALVANIZING ALL ACROSS FEDERAL 919 00:32:41,000 --> 00:32:42,000 GOVERNMENT FOR THIS SHARED 920 00:32:42,000 --> 00:32:44,240 MISSION TO END CANCER AS WE KNOW 921 00:32:44,240 --> 00:32:44,400 IT. 922 00:32:44,400 --> 00:32:47,240 WITH THAT I WILL CLOSE AND I 923 00:32:47,240 --> 00:32:48,880 HOPE I'VE LEFT TIME FOR 924 00:32:48,880 --> 00:32:49,960 QUESTIONS. 925 00:32:49,960 --> 00:32:51,200 THANK YOU. 926 00:32:51,200 --> 00:32:51,480 >> GREAT. 927 00:32:51,480 --> 00:32:52,720 THANKS, NED. 928 00:32:52,720 --> 00:32:54,840 TOUR DE FORCE. 929 00:32:54,840 --> 00:32:56,880 WE HAVE 10 OR 11 MINUTES FOR 930 00:32:56,880 --> 00:32:57,240 SOME QUESTIONS. 931 00:32:57,240 --> 00:32:59,120 IF YOU HAVE A QUESTION, PLEASE 932 00:32:59,120 --> 00:33:01,840 USE THE REACTION TOOL AND RAISE 933 00:33:01,840 --> 00:33:03,600 YOUR HAND. 934 00:33:03,600 --> 00:33:05,880 YOU'LL BE PRIORITIZED AND I CAN 935 00:33:05,880 --> 00:33:06,760 SEE IT. 936 00:33:06,760 --> 00:33:10,320 I'LL TAKE PRIVILEGE AND ASK A 937 00:33:10,320 --> 00:33:11,880 QUESTION, NED. 938 00:33:11,880 --> 00:33:14,560 MOONSHOT IS DEFINITELY A HUGE 939 00:33:14,560 --> 00:33:15,400 ENDEAVOR, HUGE INITIATIVE, 940 00:33:15,400 --> 00:33:16,960 REQUIRES A LOT OF SUPPORT. 941 00:33:16,960 --> 00:33:19,200 THE SUPPORT FROM THE PRESIDENT 942 00:33:19,200 --> 00:33:20,720 AND THE FIRST LADY AND VICE 943 00:33:20,720 --> 00:33:22,960 PRESIDENT WAS PALPABLE IN THAT 944 00:33:22,960 --> 00:33:23,160 ROOM. 945 00:33:23,160 --> 00:33:26,280 AND, YOU KNOW, BUT I WOULD LIKE 946 00:33:26,280 --> 00:33:28,000 TO ASK YOU A QUESTION. 947 00:33:28,000 --> 00:33:31,600 IT'S RELATED TO THE MOONSHOT. 948 00:33:31,600 --> 00:33:35,840 THE RECENT NEWS ABOUT ERIC, DR. 949 00:33:35,840 --> 00:33:37,400 LANDER, HOW HIS RESIGNATION 950 00:33:37,400 --> 00:33:39,160 COULD IMPACT THE MOONSHOT GIVEN 951 00:33:39,160 --> 00:33:41,400 HIS ROLE AS SCIENCE ADVISER AND 952 00:33:41,400 --> 00:33:42,400 HIS REAL COMMITMENT, RIGHT? 953 00:33:42,400 --> 00:33:45,920 AND SUPPORT FOR THE MOONSHOT. 954 00:33:45,920 --> 00:33:46,680 ANY THOUGHTS? 955 00:33:46,680 --> 00:33:51,440 >> YEAH, THANKS FOR THE 956 00:33:51,440 --> 00:33:51,720 QUESTION. 957 00:33:51,720 --> 00:33:53,000 I THINK, YOU KNOW, THE WHITE 958 00:33:53,000 --> 00:33:55,280 HOUSE HAS BEEN VERY CLEAR THAT 959 00:33:55,280 --> 00:33:56,680 THIS INITIATIVE IS BIGGER THAN 960 00:33:56,680 --> 00:33:57,680 ANY ONE PERSON. 961 00:33:57,680 --> 00:34:00,040 AND THERE ARE A TREMENDOUS 962 00:34:00,040 --> 00:34:01,760 NUMBER OF TALENTED AND TERRIFIC 963 00:34:01,760 --> 00:34:02,680 SCIENTISTS ACROSS GOVERNMENT, 964 00:34:02,680 --> 00:34:03,680 OUTSIDE OF GOVERNMENT, THAT ARE 965 00:34:03,680 --> 00:34:06,560 AVAILABLE TO HELP WITH THIS. 966 00:34:06,560 --> 00:34:10,320 SO I THINK WE'LL BE FINE. 967 00:34:10,320 --> 00:34:14,280 THIS-- WE'RE JUST AT THE 968 00:34:14,280 --> 00:34:16,040 STARTING PHASE, AND I THINK 969 00:34:16,040 --> 00:34:17,400 THERE ARE NO SHORTAGE OF GREAT 970 00:34:17,400 --> 00:34:19,760 IDEAS IN THE WHITE HOUSE ON HOW 971 00:34:19,760 --> 00:34:26,760 TO DEVELOP THE NEW MOONSHOT. 972 00:34:26,760 --> 00:34:28,960 SO, IT IS OF COURSE -- WE'RE 973 00:34:28,960 --> 00:34:30,280 SADDENED TO HEAR ABOUT THE 974 00:34:30,280 --> 00:34:34,040 BEHAVIOR THAT LED TO DR. 975 00:34:34,040 --> 00:34:43,200 LANDER'S RESIGNATION, NOT HOW 976 00:34:43,200 --> 00:34:44,200 WE EXPECT TO DO BUSINESS IN THE 977 00:34:44,200 --> 00:34:46,800 FEDERAL GOVERNMENT OR NCI. 978 00:34:46,800 --> 00:34:49,160 WE'LL RECOVER WITHOUT MUCH OF A 979 00:34:49,160 --> 00:34:50,440 HICCUP AND BE FINE. 980 00:34:50,440 --> 00:34:54,520 >> I SEE THREE HANDS. 981 00:34:54,520 --> 00:34:55,800 ELECTRA, ANDREA, AMY. 982 00:34:55,800 --> 00:34:57,600 >> THANK YOU, JOHN. 983 00:34:57,600 --> 00:34:58,560 THANK YOU, DR. SHARPLESS, FOR 984 00:34:58,560 --> 00:35:02,400 THE TALK. 985 00:35:02,400 --> 00:35:03,040 IT'S REFRESHING. 986 00:35:03,040 --> 00:35:05,000 I'M ECSTATICS ABOUT THE SECOND 987 00:35:05,000 --> 00:35:12,880 MOONSHOT AND THE FOCUS FROM THE 988 00:35:12,880 --> 00:35:14,200 WHITE HOUSE, ALL YOU'RE DOING. 989 00:35:14,200 --> 00:35:18,720 I WOULD LIKE TO ASK THAT THERE 990 00:35:18,720 --> 00:35:21,400 BE INCLUSION OF ANOTHER PILLAR 991 00:35:21,400 --> 00:35:24,240 IN YOUR PLAN. 992 00:35:24,240 --> 00:35:26,400 AND YOU HAVE THE PATIENTS. 993 00:35:26,400 --> 00:35:28,160 YOU ADDED NAVIGATORS. 994 00:35:28,160 --> 00:35:32,960 REALLY THE COMMUNITY NEEDS TO BE 995 00:35:32,960 --> 00:35:34,960 ANOTHER PILLAR, BECAUSE, YOU 996 00:35:34,960 --> 00:35:39,000 KNOW, WE CAN PREVENT SIX CANCERS 997 00:35:39,000 --> 00:35:41,200 WITH HPV VACCINE, UPTAKE AT BEST 998 00:35:41,200 --> 00:35:41,520 50%. 999 00:35:41,520 --> 00:35:43,200 WE CAN PREVENT COLON CANCER WITH 1000 00:35:43,200 --> 00:35:43,480 SCREENING. 1001 00:35:43,480 --> 00:35:44,360 OUR RATES ARE NOT WHERE THEY 1002 00:35:44,360 --> 00:35:46,240 NEED TO BE. 1003 00:35:46,240 --> 00:35:48,560 AND WE CAN ELIMINATE CERVICAL 1004 00:35:48,560 --> 00:35:50,440 CANCER, AS WE KNOW IT NOW. 1005 00:35:50,440 --> 00:35:51,640 AND WE'RE NOT. 1006 00:35:51,640 --> 00:35:52,720 AND WHY? 1007 00:35:52,720 --> 00:35:55,200 BECAUSE THAT ONE PILLAR IS 1008 00:35:55,200 --> 00:35:55,640 MISSING. 1009 00:35:55,640 --> 00:35:57,400 WE HAVEN'T TOLD PEOPLE HOW. 1010 00:35:57,400 --> 00:35:59,560 I LOVE -- I REALLY APPRECIATE 1011 00:35:59,560 --> 00:36:03,200 THE PRESIDENT SAYING GO GET 1012 00:36:03,200 --> 00:36:04,960 SCREENED AND, DOCTORS, SCREEN 1013 00:36:04,960 --> 00:36:05,520 YOUR PATIENTS. 1014 00:36:05,520 --> 00:36:06,680 IT'S NOT ENOUGH TO TELL PEOPLE 1015 00:36:06,680 --> 00:36:07,400 TO DO IT. 1016 00:36:07,400 --> 00:36:09,000 WE HAVE TO TELL THEM WHY AND 1017 00:36:09,000 --> 00:36:11,720 HAVE TO TELL THEM HOW. 1018 00:36:11,720 --> 00:36:12,840 AND PEOPLE LIKE ME, THAT'S WHAT 1019 00:36:12,840 --> 00:36:14,040 I DO IN MY RESEARCH. 1020 00:36:14,040 --> 00:36:16,080 I'VE DONE THAT FOR ALMOST 30 1021 00:36:16,080 --> 00:36:17,080 YEARS NOW. 1022 00:36:17,080 --> 00:36:19,360 AND IT'S NOT AN EASY THING. 1023 00:36:19,360 --> 00:36:20,840 IT'S NOT EASY. 1024 00:36:20,840 --> 00:36:22,920 AND WITHOUT CONSIDERATION OF 1025 00:36:22,920 --> 00:36:23,920 THAT, UNFORTUNATELY WE'RE NOT 1026 00:36:23,920 --> 00:36:26,200 GOING TO REACH THOSE TARGETS. 1027 00:36:26,200 --> 00:36:28,000 AND WE CAN REACH THOSE TARGETS 1028 00:36:28,000 --> 00:36:30,800 BECAUSE OF ALL THE FABULOUS 1029 00:36:30,800 --> 00:36:31,680 RESEARCH THAT'S ONGOING. 1030 00:36:31,680 --> 00:36:34,400 WE HAVE TO HAVE THAT CRITICAL 1031 00:36:34,400 --> 00:36:34,880 PIECE. 1032 00:36:34,880 --> 00:36:37,200 SO, I'M JUST ASKING IF YOU COULD 1033 00:36:37,200 --> 00:36:39,760 ADD A PILLAR TO YOUR PLAN AND 1034 00:36:39,760 --> 00:36:41,960 SOMEHOW BRING THAT TO THE 1035 00:36:41,960 --> 00:36:43,040 ATTENTION OF THE WHITE HOUSE 1036 00:36:43,040 --> 00:36:45,000 COMMITTEE, THAT THAT HAS TO BE 1037 00:36:45,000 --> 00:36:45,320 PART OF IT. 1038 00:36:45,320 --> 00:36:45,960 THANK YOU. 1039 00:36:45,960 --> 00:36:48,400 THANK YOU VERY MUCH. 1040 00:36:48,400 --> 00:36:50,320 >> SURE. 1041 00:36:50,320 --> 00:36:53,960 THANK YOU, ELECTRA. 1042 00:36:53,960 --> 00:36:55,400 WE SHARE YOUR ENTHUSIASM, I 1043 00:36:55,400 --> 00:36:57,280 THINK IT'S SPOT ON. 1044 00:36:57,280 --> 00:37:00,600 AND ASPIRATIONS IN THAT AREA. 1045 00:37:00,600 --> 00:37:02,120 AS YOU KNOW, NCI LOVES HPV 1046 00:37:02,120 --> 00:37:05,200 RESEARCH, HOW TO MAKE THAT A 1047 00:37:05,200 --> 00:37:05,800 REALITY. 1048 00:37:05,800 --> 00:37:07,400 THE PILLARS I SHOWED, I WANT TO 1049 00:37:07,400 --> 00:37:09,000 BE CLEAR, THAT'S NOT A FINAL 1050 00:37:09,000 --> 00:37:09,360 VERSION, RIGHT? 1051 00:37:09,360 --> 00:37:12,640 THIS IS A WORK IN PROGRESS. 1052 00:37:12,640 --> 00:37:15,280 THE WHITE HOUSE IS, AS I SAID, 1053 00:37:15,280 --> 00:37:17,280 STILL TALKING TO A LOT OF PEOPLE 1054 00:37:17,280 --> 00:37:19,000 BEYOND JUST THE NCI ON REALLY 1055 00:37:19,000 --> 00:37:20,000 WHAT THE PRIORITIES AND FOCUS 1056 00:37:20,000 --> 00:37:21,720 SHOULD BE. 1057 00:37:21,720 --> 00:37:23,200 I THINK SOME OF THIS PLATFORM 1058 00:37:23,200 --> 00:37:24,960 DEVELOPMENT IS GOING TO BE WORK 1059 00:37:24,960 --> 00:37:27,600 OF THE CANCER CABINET THAT I 1060 00:37:27,600 --> 00:37:28,040 ALLUDED TO. 1061 00:37:28,040 --> 00:37:29,760 I WILL VERY MUCH BRING THAT 1062 00:37:29,760 --> 00:37:31,400 CONCERN, VOICE OF THE COMMUNITY, 1063 00:37:31,400 --> 00:37:32,360 TO THESE DISCUSSIONS SO THANK 1064 00:37:32,360 --> 00:37:35,560 YOU FOR POINTING THAT OUT. 1065 00:37:35,560 --> 00:37:36,160 >> FANTASTIC. 1066 00:37:36,160 --> 00:37:37,720 THANKS, NED. 1067 00:37:37,720 --> 00:37:38,040 ANDREA? 1068 00:37:38,040 --> 00:37:39,240 >> YES, I WANTED TO SAY 1069 00:37:39,240 --> 00:37:40,440 SOMETHING SIMILAR ABOUT THE FACT 1070 00:37:40,440 --> 00:37:43,040 I WAS HAPPY TO SEE ACCESS 1071 00:37:43,040 --> 00:37:44,600 INCLUDED IN ONE OF THOSE 1072 00:37:44,600 --> 00:37:46,040 PILLARS, TO ADDRESS THE 1073 00:37:46,040 --> 00:37:47,160 DISPARITIES THAT WE HAVE IN 1074 00:37:47,160 --> 00:37:48,280 HEALTH CARE. 1075 00:37:48,280 --> 00:37:49,840 I COULDN'T HELP BUT THINK WHEN 1076 00:37:49,840 --> 00:37:56,920 YOU SHOWED THE RFI FOR THE BLOOD 1077 00:37:56,920 --> 00:38:00,080 BORNE DETECTION MCV WE NEED 1078 00:38:00,080 --> 00:38:01,440 SOMETHING SIMILAR FOR PROVIDERS 1079 00:38:01,440 --> 00:38:03,720 WITH IDEAS ABOUT HOW TO RESOLVE 1080 00:38:03,720 --> 00:38:05,120 THAT DISCONNECTION THAT ELECTRA 1081 00:38:05,120 --> 00:38:06,800 WAS TALKING ABOUT WITH THE 1082 00:38:06,800 --> 00:38:07,200 COMMUNITY. 1083 00:38:07,200 --> 00:38:09,920 IT'S JUST AS IMPORTANT TO HAVE 1084 00:38:09,920 --> 00:38:12,640 RFIS AND RFAs ON HOW DO WE 1085 00:38:12,640 --> 00:38:14,080 IMPROVE ACCESS TO ALL THESE 1086 00:38:14,080 --> 00:38:15,600 FABULOUS TREATMENTS THAT WE'RE 1087 00:38:15,600 --> 00:38:17,400 ABOUT TO DEVELOP AND WE FABULOUS 1088 00:38:17,400 --> 00:38:19,560 DISCOVERIES BUT IF WE CAN'T GET 1089 00:38:19,560 --> 00:38:20,280 TO EVERY SINGLE AMERICAN THEN 1090 00:38:20,280 --> 00:38:22,800 IT'S NOT GOING TO GET US TO OUR 1091 00:38:22,800 --> 00:38:24,440 GOAL OF REDUCING CANCER DEATHS. 1092 00:38:24,440 --> 00:38:27,960 SO I WOULD LIKE TO SEE US DO 1093 00:38:27,960 --> 00:38:32,320 MORE RFIS AND RFAs ON ACCESS 1094 00:38:32,320 --> 00:38:33,920 AND IMPROVE -- DECREASING 1095 00:38:33,920 --> 00:38:37,000 DISPARITIES BY INVOLVING THE 1096 00:38:37,000 --> 00:38:39,120 COMMUNITY MORE. 1097 00:38:39,120 --> 00:38:41,120 >> I THINK THE -- I'M CALLING 1098 00:38:41,120 --> 00:38:42,720 THIS IMPLEMENTATION SCIENCE 1099 00:38:42,720 --> 00:38:43,000 RESEARCH. 1100 00:38:43,000 --> 00:38:44,680 IF YOU HAVE SOMETHING DIFFERENT 1101 00:38:44,680 --> 00:38:45,880 IN MIND, CLARIFY. 1102 00:38:45,880 --> 00:38:47,640 I BELIEVE THIS IS AN IMPORTANT 1103 00:38:47,640 --> 00:38:49,080 TOPIC FOR CANCER RESEARCH AND I 1104 00:38:49,080 --> 00:38:51,240 AGREE WITH YOU. 1105 00:38:51,240 --> 00:38:54,120 IT DOESN'T DO VERY MANY MANY 1106 00:38:54,120 --> 00:38:57,800 GOOD IF WE HAVE GREAT THERAPIES 1107 00:38:57,800 --> 00:38:59,240 INTERESTED IN TERTIARY CARE 1108 00:38:59,240 --> 00:39:00,160 CENTERS AND NEVER DISSEMINATED 1109 00:39:00,160 --> 00:39:01,600 INTO THE COMMUNITIES TO CHANGE 1110 00:39:01,600 --> 00:39:01,880 OUTCOMES. 1111 00:39:01,880 --> 00:39:05,280 THE NCI IS A STRONG AND LIVELY 1112 00:39:05,280 --> 00:39:06,680 RESEARCH PORTFOLIO IN 1113 00:39:06,680 --> 00:39:10,960 IMPLEMENTATION SCIENCE, A FAIR 1114 00:39:10,960 --> 00:39:13,880 QUESTION TO ASK ARE THERE TOPICS 1115 00:39:13,880 --> 00:39:15,480 AND AREAS WE SHOULD FURTHER 1116 00:39:15,480 --> 00:39:18,280 ADDRESS AND WORK ON. 1117 00:39:18,280 --> 00:39:19,400 WE'VE HAD PRESENTATIONS AROUND 1118 00:39:19,400 --> 00:39:20,400 IMPLEMENTATION SCIENCE IN THE 1119 00:39:20,400 --> 00:39:25,080 PAST, CAN DO MORE IN THE FUTURE. 1120 00:39:25,080 --> 00:39:26,480 AND CERTAINLY HAVE PLANNED, HAVE 1121 00:39:26,480 --> 00:39:28,040 PLANNED AND CONTINUE TO PLAN 1122 00:39:28,040 --> 00:39:32,480 FUNDING OPPORTUNITIES IN THIS 1123 00:39:32,480 --> 00:39:32,720 AREA. 1124 00:39:32,720 --> 00:39:34,800 BUT I THINK AGAINST THAT 1125 00:39:34,800 --> 00:39:38,600 BACKDROP, NOW THERE'S A NEW 1126 00:39:38,600 --> 00:39:38,880 MOONSHOT. 1127 00:39:38,880 --> 00:39:46,120 AND SORT OF THE SAME POINT 1128 00:39:46,120 --> 00:39:47,200 ELECTRA WAS MAKING, NOT ONLY 1129 00:39:47,200 --> 00:39:48,960 GOING TO THE COMMUNITY BUT 1130 00:39:48,960 --> 00:39:49,920 RECEIVING FROM THE COMMUNITY, A 1131 00:39:49,920 --> 00:39:53,080 CRITICAL PART OF ANY SUCCESSFUL 1132 00:39:53,080 --> 00:39:57,880 ENDEAVOR. 1133 00:39:57,880 --> 00:39:59,280 >> THANKS, NED. 1134 00:39:59,280 --> 00:39:59,680 AMY? 1135 00:39:59,680 --> 00:40:00,240 >> LOVELY PRESENTATION. 1136 00:40:00,240 --> 00:40:03,320 HOW CAN WE GET OUR CANCER CENTER 1137 00:40:03,320 --> 00:40:05,040 DIRECTORS, THE VARIOUS PROGRAMS 1138 00:40:05,040 --> 00:40:09,000 IN THE NCI PORTFOLIO, TO REALLY 1139 00:40:09,000 --> 00:40:10,280 HELP ASSIST IN ADVOCATING FOR 1140 00:40:10,280 --> 00:40:11,720 LEGISLATION EXPANSION INTO THESE 1141 00:40:11,720 --> 00:40:12,000 ENDEAVORS? 1142 00:40:12,000 --> 00:40:14,160 DO YOU HAVE SOME SORT OF 1143 00:40:14,160 --> 00:40:15,680 SPECIFIC RECOMMENDATIONS THAT WE 1144 00:40:15,680 --> 00:40:18,400 COULD EXTEND OUT TO THESE FOLKS 1145 00:40:18,400 --> 00:40:22,960 TO HELP US HELP THE NCI? 1146 00:40:22,960 --> 00:40:24,280 >> AS A FEDERAL OFFICIAL, I WILL 1147 00:40:24,280 --> 00:40:27,600 NOT BE GIVING THE NCI DIRECTORS 1148 00:40:27,600 --> 00:40:29,440 HOW TO PASS LEGISLATION. 1149 00:40:29,440 --> 00:40:30,600 >> HOW ABOUT UNOFFICIAL ADVICE? 1150 00:40:30,600 --> 00:40:32,360 >> NO, NO, I CAN'T DO THAT. 1151 00:40:32,360 --> 00:40:37,800 YOU KNOW, I WILL TELL YOU, 1152 00:40:37,800 --> 00:40:39,000 CANCER CENTER DIRECTORS TALK TO 1153 00:40:39,000 --> 00:40:41,560 ME A LOT ABOUT AREAS WHERE THEY 1154 00:40:41,560 --> 00:40:43,280 THINK CHANGES TO POLICY OR LAW 1155 00:40:43,280 --> 00:40:44,800 CAN BE HELPFUL FOR CANCER 1156 00:40:44,800 --> 00:40:47,400 PATIENTS AND REALLY INTERESTING 1157 00:40:47,400 --> 00:40:48,640 ISSUES, LIKE, YOU KNOW, CARE 1158 00:40:48,640 --> 00:40:51,120 ACROSS STATE LINES WAS A BIG ONE 1159 00:40:51,120 --> 00:40:52,600 DURING THE PANDEMIC, FOR 1160 00:40:52,600 --> 00:40:55,600 EXAMPLE, OR COVERAGE FOR 1161 00:40:55,600 --> 00:40:56,200 SCREENINGS, TERRIFICALLY 1162 00:40:56,200 --> 00:40:58,840 IMPORTANT TOPICS AND I WILL ALSO 1163 00:40:58,840 --> 00:41:01,280 SAY I HAVE 100% CERTAINTY THAT 1164 00:41:01,280 --> 00:41:02,920 CONGRESS LISTENS TO THE CANCER 1165 00:41:02,920 --> 00:41:03,440 CENTER DIRECTORS. 1166 00:41:03,440 --> 00:41:07,800 THEY ARE A VERY POWERFUL VOICE. 1167 00:41:07,800 --> 00:41:10,000 PARTICULARLY IF THE CANCER 1168 00:41:10,000 --> 00:41:13,800 CENTER IS IN THE CONGRESSMAN'S 1169 00:41:13,800 --> 00:41:15,200 SPECIFIC DISTRICT, SUCCESSFUL TO 1170 00:41:15,200 --> 00:41:17,040 CONVEY WISHES TO CONGRESS BUT AS 1171 00:41:17,040 --> 00:41:18,360 NCI DIRECTOR I PROBABLY OUGHT TO 1172 00:41:18,360 --> 00:41:20,400 STAY OUT OF GIVING THEM ADVICE 1173 00:41:20,400 --> 00:41:21,760 ON WHAT, EVEN THOUGH I SHARE 1174 00:41:21,760 --> 00:41:24,800 MANY OF YOUR GOALS AND HOPES IN 1175 00:41:24,800 --> 00:41:25,240 THAT AREA. 1176 00:41:25,240 --> 00:41:28,640 >> WE HAVE JUST A COUPLE MORE 1177 00:41:28,640 --> 00:41:28,880 MINUTES. 1178 00:41:28,880 --> 00:41:31,480 IT WOULD BE GREAT IF YOU COULD 1179 00:41:31,480 --> 00:41:32,440 GIVE YOUR PERSPECTIVE SITTING IN 1180 00:41:32,440 --> 00:41:33,760 THE ROOM. 1181 00:41:33,760 --> 00:41:35,600 DID ANYTHING RESONATE IN TERMS 1182 00:41:35,600 --> 00:41:38,520 OF DISCIPLINES OR SPECIFIC AREAS 1183 00:41:38,520 --> 00:41:40,600 OF RESEARCH THAT YOU COULD SORT 1184 00:41:40,600 --> 00:41:43,360 OF -- THAT MIGHT HAVE BEEN 1185 00:41:43,360 --> 00:41:45,600 HIGHLIGHTED DURING THE 1186 00:41:45,600 --> 00:41:46,800 PRESIDENT'S COMMENTS? 1187 00:41:46,800 --> 00:41:49,280 >> YEAH, SURE. 1188 00:41:49,280 --> 00:41:52,200 I THOUGHT THE PARTS THAT I FOUND 1189 00:41:52,200 --> 00:41:53,600 PARTICULARLY COMPELLING -- 1190 00:41:53,600 --> 00:41:55,520 FIRST, THE SPEAKERS WERE -- FOUR 1191 00:41:55,520 --> 00:41:57,160 SPEAKERS WERE TERRIFIC. 1192 00:41:57,160 --> 00:41:59,200 IT WAS A GREAT PROGRAM. 1193 00:41:59,200 --> 00:42:00,920 AS I SAID, IT WAS -- I TOLD 1194 00:42:00,920 --> 00:42:02,880 SEVERAL OF YOU IT REMINDED ME OF 1195 00:42:02,880 --> 00:42:04,080 A WEDDING, ALL THESE PEOPLE YOU 1196 00:42:04,080 --> 00:42:06,480 HADN'T SEEN IN A WHILE, ALL 1197 00:42:06,480 --> 00:42:08,360 TOGETHER IN REAL LIFE, EVERYBODY 1198 00:42:08,360 --> 00:42:11,960 IN A GOOD MOOD, A GREAT PAGEANT. 1199 00:42:11,960 --> 00:42:17,680 A LOVELY EVENT WITH TERRIFIC SPEAKERS. 1200 00:42:17,680 --> 00:42:19,080 I THOUGHT THE PRESIDENT -- THE 1201 00:42:19,080 --> 00:42:20,040 PRESIDENT SINGLED OUT THREE 1202 00:42:20,040 --> 00:42:20,720 THINGS IN THE FIRST 1203 00:42:20,720 --> 00:42:21,400 ANNOUNCEMENT. 1204 00:42:21,400 --> 00:42:23,200 THIS IS NOT THE LAST 1205 00:42:23,200 --> 00:42:24,320 ANNOUNCEMENT. 1206 00:42:24,320 --> 00:42:25,960 THINGS THE PRESIDENT DIDN'T SAY, 1207 00:42:25,960 --> 00:42:27,480 DON'T READ ANYTHING INTO IT YET, 1208 00:42:27,480 --> 00:42:30,560 BUT THE THINGS SORT OF NEW HERE, 1209 00:42:30,560 --> 00:42:33,280 PARTICULAR FOCUS, WERE THE 1210 00:42:33,280 --> 00:42:35,760 ANNOUNCEMENT FOR THIS GOAL OF 1211 00:42:35,760 --> 00:42:36,800 DECLINING CANCER MORTALITY, 50% 1212 00:42:36,800 --> 00:42:39,200 REDUCTION IS A BIG DEAL. 1213 00:42:39,200 --> 00:42:41,280 THE FOCUS AROUND PREVENTION, 1214 00:42:41,280 --> 00:42:42,960 SCREENING, EARLY DETECTION, EVEN 1215 00:42:42,960 --> 00:42:45,000 THE MENTION OF MULTI-CANCER 1216 00:42:45,000 --> 00:42:46,000 EARLY DETECTION TESTS IS MUSIC 1217 00:42:46,000 --> 00:42:47,840 TO THE NIH'S EARS BECAUSE THOSE 1218 00:42:47,840 --> 00:42:50,000 TRIALS ARE SUPER IMPORTANT, 1219 00:42:50,000 --> 00:42:51,280 RESEARCH IS INCREDIBLY INTRICATE 1220 00:42:51,280 --> 00:42:52,200 AND DIFFICULT AND EXPENSIVE. 1221 00:42:52,200 --> 00:42:55,400 THAT'S THE KIND OF AREA WHERE 1222 00:42:55,400 --> 00:42:57,400 SUPPORT WOULD BE APPRECIATED. 1223 00:42:57,400 --> 00:42:59,600 AND LASTLY WAS THE SORT OF 1224 00:42:59,600 --> 00:43:02,200 COMMITMENT TO MAKING UP MISSED 1225 00:43:02,200 --> 00:43:02,880 SCREENING, VERY MUCH TOP OF MIND 1226 00:43:02,880 --> 00:43:05,520 INTEREST IN THE WHITE HOUSE, 1227 00:43:05,520 --> 00:43:07,040 RECOVERING FROM THE PANDEMIC, 1228 00:43:07,040 --> 00:43:10,640 AND SO SORT OF RIGHTING THE SHIP 1229 00:43:10,640 --> 00:43:12,400 OF CANCER CARE, NOT JUST 1230 00:43:12,400 --> 00:43:14,080 SCREENING, LOTS OF ASPECTS, BUT 1231 00:43:14,080 --> 00:43:18,200 RUSHING TO NORMALCY IN TERMS OF 1232 00:43:18,200 --> 00:43:19,040 ELECTIVE SURGERIES, MISSED 1233 00:43:19,040 --> 00:43:20,200 DIAGNOSES IS A TOP PRIORITY. 1234 00:43:20,200 --> 00:43:21,920 THE FIRST LADY HAS BEEN SPEAKING 1235 00:43:21,920 --> 00:43:23,200 ABOUT THIS, THE PRESIDENT SHARES 1236 00:43:23,200 --> 00:43:23,760 THAT GOAL. 1237 00:43:23,760 --> 00:43:25,760 I THINK THOSE ARE THE SORT OF 1238 00:43:25,760 --> 00:43:32,080 FIRST COUPLE THINGS ALONG WITH 1239 00:43:32,080 --> 00:43:33,600 THE ANNOUNCEMENT OF THE CANCER 1240 00:43:33,600 --> 00:43:33,880 CABINET. 1241 00:43:33,880 --> 00:43:34,960 KAREN AND JOHN WERE THERE. 1242 00:43:34,960 --> 00:43:36,440 MAYBE A FEW OTHERS AS WELL. 1243 00:43:36,440 --> 00:43:38,760 IF OTHERS HAD THOUGHTS I DIDN'T 1244 00:43:38,760 --> 00:43:40,200 CAPTURE, KAREN AND JOHN, WHAT 1245 00:43:40,200 --> 00:43:42,320 WERE YOUR THOUGHTS? 1246 00:43:42,320 --> 00:43:44,600 >> NO, YOU CAPTURED IT. 1247 00:43:44,600 --> 00:43:45,880 GREAT JOB. 1248 00:43:45,880 --> 00:43:49,920 THE EARLY DETECTION PART WAS 1249 00:43:49,920 --> 00:43:53,120 JUST SO -- WAS FRONT AND CENTER. 1250 00:43:53,120 --> 00:43:55,480 SO SCREENING, EARLY DETECTION 1251 00:43:55,480 --> 00:43:56,160 WAS FANTASTIC. 1252 00:43:56,160 --> 00:43:58,040 THANKS, NED. 1253 00:43:58,040 --> 00:43:59,760 WE'RE RIGHT ON TIME. 1254 00:43:59,760 --> 00:44:01,480 RIGHT AT THE 45-MINUTE MARK. 1255 00:44:01,480 --> 00:44:03,600 SO WHY DON'T WE MOVE AHEAD. 1256 00:44:03,600 --> 00:44:05,640 IF YOU HAVE ANY ADDITIONAL 1257 00:44:05,640 --> 00:44:06,840 COMMENTS OR QUESTIONS FOR DR. 1258 00:44:06,840 --> 00:44:08,480 SHARPLESS, PLEASE PUT THEM IN 1259 00:44:08,480 --> 00:44:11,120 THE CHAT. 1260 00:44:11,120 --> 00:44:12,760 NEXT UP, WE'LL HAVE LEGISLATIVE 1261 00:44:12,760 --> 00:44:15,840 REPORT FROM M.K. HOLOHAN. 1262 00:44:15,840 --> 00:44:16,040 M.K.? 1263 00:44:16,040 --> 00:44:18,280 >> THANK YOU FOR THE OPPORTUNITY 1264 00:44:18,280 --> 00:44:20,080 TO SPEAK WITH YOU TODAY. 1265 00:44:20,080 --> 00:44:21,600 IN THE TIME WE HAVE TODAY I'M 1266 00:44:21,600 --> 00:44:26,920 GOING TO DO A BRIEF OVERVIEW. 1267 00:44:26,920 --> 00:44:28,320 THERE'S MORE DETAILS IN THE 1268 00:44:28,320 --> 00:44:28,920 LEGISLATIVE UPDATE MATERIALS, 1269 00:44:28,920 --> 00:44:33,000 AND IF YOU OR YOUR STAFF WOULD 1270 00:44:33,000 --> 00:44:34,600 LIKE MORE INFORMATION OR HAVE 1271 00:44:34,600 --> 00:44:35,760 QUESTIONS ABOUT THINGS YOU HEARD 1272 00:44:35,760 --> 00:44:36,640 ABOUT LEGISLATION GET IN TOUCH 1273 00:44:36,640 --> 00:44:37,280 WITH US. 1274 00:44:37,280 --> 00:44:39,600 MY TEAM AND I WOULD BE HAPPY TO 1275 00:44:39,600 --> 00:44:41,520 TALK WITH YOU AND YOUR STAFF. 1276 00:44:41,520 --> 00:44:43,560 NEXT SLIDE PLEASE. 1277 00:44:43,560 --> 00:44:45,000 SO I'M GOING TO DO A BRIEF 1278 00:44:45,000 --> 00:44:48,040 OVERVIEW IN THE TIME TODAY, 1279 00:44:48,040 --> 00:44:50,480 TALKING ABOUT FY 22 1280 00:44:50,480 --> 00:44:51,120 APPROPRIATIONS, GOOD NEWS 1281 00:44:51,120 --> 00:44:52,440 FINALLY, I'LL BE TELLING YOU 1282 00:44:52,440 --> 00:44:54,600 ABOUT WHAT WE KNOW SO FAR. 1283 00:44:54,600 --> 00:44:57,000 WE'RE NOT QUITE OUT OF THE WOODS 1284 00:44:57,000 --> 00:45:00,840 YET BUT REALLY BIG NEWS LAST 1285 00:45:00,840 --> 00:45:01,080 NIGHT. 1286 00:45:01,080 --> 00:45:03,600 LEGISLATION AND ISSUES TO WATCH, 1287 00:45:03,600 --> 00:45:05,080 TWO THINGS, I'LL TALK ABOUT 1288 00:45:05,080 --> 00:45:09,120 THREE NOW, CURES AND PREVENT 1289 00:45:09,120 --> 00:45:09,760 PANDEMIC, GOING INTO LATER, AT 1290 00:45:09,760 --> 00:45:11,440 THE END TALKING ABOUT 1291 00:45:11,440 --> 00:45:15,520 RETIREMENTS AND OUTLOOK FOR THE 1292 00:45:15,520 --> 00:45:15,800 MIDTERMS. 1293 00:45:15,800 --> 00:45:17,400 GIVING YOU BACKGROUND ON 1294 00:45:17,400 --> 00:45:20,400 TELEHEALTH, THIS IS OF 1295 00:45:20,400 --> 00:45:21,520 TREMENDOUS INTEREST TO A LOT OF 1296 00:45:21,520 --> 00:45:23,000 PEOPLE, IT'S BECOME A REAL ISSUE 1297 00:45:23,000 --> 00:45:25,240 IN THE HEALTH SPACE, IN 1298 00:45:25,240 --> 00:45:25,520 CONGRESS. 1299 00:45:25,520 --> 00:45:27,800 THERE'S OVER 50 BILLS INTRODUCED 1300 00:45:27,800 --> 00:45:29,320 IN THIS CONGRESS THAT TOUCH ON 1301 00:45:29,320 --> 00:45:29,600 TELEHEALTH. 1302 00:45:29,600 --> 00:45:31,840 THIS IS A PRIORITY FOR THE 1303 00:45:31,840 --> 00:45:35,840 ADMINISTRATION, HHS IS VERY 1304 00:45:35,840 --> 00:45:36,440 ENGAGED. 1305 00:45:36,440 --> 00:45:40,480 WE DETAIL ON THE UPDATE A FEW OF 1306 00:45:40,480 --> 00:45:41,400 THE SPECIFIC TELEHEALTH 1307 00:45:41,400 --> 00:45:43,200 PROVISIONS GRAPPLING WITH HOW TO 1308 00:45:43,200 --> 00:45:45,520 RETAIN FLEXIBILITIES THAT PEOPLE 1309 00:45:45,520 --> 00:45:47,400 LIKE, PATIENTS LIKE, PROVIDERS 1310 00:45:47,400 --> 00:45:48,920 LIKE, GRAPPLING WITH PAYMENT 1311 00:45:48,920 --> 00:45:50,120 ISSUES AND CONCERNS ABOUT FRAUD. 1312 00:45:50,120 --> 00:45:52,000 AND HOW IS THIS GOING TO FIT 1313 00:45:52,000 --> 00:45:52,840 INTO THE EXISTING SYSTEM. 1314 00:45:52,840 --> 00:45:57,400 THIS IS AN ISSUE WE'LL BE 1315 00:45:57,400 --> 00:45:58,320 TRACKING CLOSELY AND IT'S 1316 00:45:58,320 --> 00:45:59,840 PROBABLY -- IT WILL BE LATER 1317 00:45:59,840 --> 00:46:01,440 INTO THE YEAR, PROBABLY IN THE 1318 00:46:01,440 --> 00:46:02,320 FALL WHEN WE SEE LEGISLATION 1319 00:46:02,320 --> 00:46:05,520 MOVE BUT THIS IS A VERY ACTIVE 1320 00:46:05,520 --> 00:46:06,080 AREA. 1321 00:46:06,080 --> 00:46:08,400 ANOTHER AREA THAT CONGRESS HAS 1322 00:46:08,400 --> 00:46:11,440 BEGUN TO PAY SOME ATTENTION TO, 1323 00:46:11,440 --> 00:46:13,720 SOMEWHAT IT'S KIND OF 1324 00:46:13,720 --> 00:46:21,720 DOVETAILING WITH DR. ROBERT 1325 00:46:21,720 --> 00:46:22,800 CALIFF'S CONFIRMATION PROCESS, 1326 00:46:22,800 --> 00:46:24,360 NOMINATED TO FDA COMMISSIONER A 1327 00:46:24,360 --> 00:46:25,440 SECOND TIME. 1328 00:46:25,440 --> 00:46:27,200 CONGRESS HAS BEGUN TO PAY 1329 00:46:27,200 --> 00:46:30,360 ATTENTION TO ACCELERATED 1330 00:46:30,360 --> 00:46:34,880 APPROVAL PROGRAM, CONCERNS ABOUT 1331 00:46:34,880 --> 00:46:37,720 PHARMACEUTICAL COMPANIES 1332 00:46:37,720 --> 00:46:38,800 PROVIDING DATA AFTER ACCELERATED 1333 00:46:38,800 --> 00:46:39,200 APPROVAL. 1334 00:46:39,200 --> 00:46:43,840 SOME WAS SORT OF BEGUN WITH 1335 00:46:43,840 --> 00:46:49,400 CONGRESSIONAL CONCERNS ABOUT THE 1336 00:46:49,400 --> 00:46:57,240 ALZHEIMER'S DRUG, APPROVAL, 1337 00:46:57,240 --> 00:46:58,960 SENATOR WYDEN ASKED HIM TO 1338 00:46:58,960 --> 00:47:01,360 COMMIT TO TAKING ACTION IN 30 1339 00:47:01,360 --> 00:47:02,560 DAYS IF CONFIRMED THAT 1340 00:47:02,560 --> 00:47:03,760 PHARMACEUTICAL COMPANIES PROVIDE 1341 00:47:03,760 --> 00:47:04,960 DATA ACCORDING TO THE PROGRAM. 1342 00:47:04,960 --> 00:47:07,000 CONGRESS IS STARTING TO PAY 1343 00:47:07,000 --> 00:47:08,200 ATTENTION IN THE BIGGER CONTEXT, 1344 00:47:08,200 --> 00:47:13,160 WE'LL HEAR MORE ABOUT THAT SOON. 1345 00:47:13,160 --> 00:47:14,680 THE COMPETES ACT, SO THIS IS -- 1346 00:47:14,680 --> 00:47:16,840 THERE'S A HOUSE AND SENATE 1347 00:47:16,840 --> 00:47:17,320 VERSION. 1348 00:47:17,320 --> 00:47:19,600 THIS BILL, THESE BILLS, HAVE HAD 1349 00:47:19,600 --> 00:47:20,120 SO MANY NAMES. 1350 00:47:20,120 --> 00:47:21,480 I THINK IT'S NOW GOING TO BE 1351 00:47:21,480 --> 00:47:22,640 CALLED THE MAKE IT IN AMERICA 1352 00:47:22,640 --> 00:47:24,720 ACT BUT WE'LL SEE IF THAT 1353 00:47:24,720 --> 00:47:24,960 STICKS. 1354 00:47:24,960 --> 00:47:27,480 THE SENATE HAD THE ENDLESS 1355 00:47:27,480 --> 00:47:30,440 FRONTIER ACT, IT THEN BECAME THE 1356 00:47:30,440 --> 00:47:31,960 UNITED STATES INNOVATION AND 1357 00:47:31,960 --> 00:47:33,480 COMPETITION ACT. 1358 00:47:33,480 --> 00:47:34,800 THE HOUSE JUST PASSED THE 1359 00:47:34,800 --> 00:47:35,880 COMPETES ACT. 1360 00:47:35,880 --> 00:47:38,760 THESE ARE -- THESE BILLS ARE 1361 00:47:38,760 --> 00:47:40,600 SIMILAR IN I HEARD IT DESCRIBED 1362 00:47:40,600 --> 00:47:41,760 YESTERDAY AS TENT POLES ARE THE 1363 00:47:41,760 --> 00:47:44,080 SAME BUT THERE'S A LOT OF 1364 00:47:44,080 --> 00:47:45,600 DIFFERENCES IN HOW MUCH FUNDING 1365 00:47:45,600 --> 00:47:47,720 NSF WOULD GET, WHERE FUNDING 1366 00:47:47,720 --> 00:47:50,800 WOULD GO SPECIFICALLY WITHIN 1367 00:47:50,800 --> 00:47:54,600 NSF, ABOUT R&D, SEMI CONDUCTOR, 1368 00:47:54,600 --> 00:47:55,760 SUPPOSED TO HELP WITH SUPPLY 1369 00:47:55,760 --> 00:48:00,480 CHAIN, A BIG PRIORITY FOR 1370 00:48:00,480 --> 00:48:02,560 SENATOR SCHUMER. 1371 00:48:02,560 --> 00:48:03,560 UNFORTUNATELY, IT'S 50-50 1372 00:48:03,560 --> 00:48:05,800 SENATE, TOUGH TO PASS ANYTHING 1373 00:48:05,800 --> 00:48:07,000 WITHOUT BIPARTISAN SUPPORT. 1374 00:48:07,000 --> 00:48:08,600 THAT WAS THE CASE BEFORE THE 1375 00:48:08,600 --> 00:48:10,920 NEWS AT THE BEGINNING OF THIS 1376 00:48:10,920 --> 00:48:11,120 MONTH. 1377 00:48:11,120 --> 00:48:15,440 THERE WAS SOME REALLY SAD NEWS 1378 00:48:15,440 --> 00:48:17,200 ABOUT SENATOR LUHAN OF NEW 1379 00:48:17,200 --> 00:48:21,160 MEXICO, 49-YEAR-OLD SENATOR HAD 1380 00:48:21,160 --> 00:48:22,880 A STROKE, SURGERY, RECUPERATING, 1381 00:48:22,880 --> 00:48:25,760 IN ADDITION TO CONCERN FOR THEIR 1382 00:48:25,760 --> 00:48:26,600 COLLEAGUE SENATE LEADERSHIP IS 1383 00:48:26,600 --> 00:48:28,520 NOW FACED WITH A REAL PROBLEM 1384 00:48:28,520 --> 00:48:29,800 THEY NEED THAT VOTE. 1385 00:48:29,800 --> 00:48:33,600 SO THIS IS GOING TO BE A SLOW 1386 00:48:33,600 --> 00:48:35,920 PROCESS OF GETTING THIS 1387 00:48:35,920 --> 00:48:36,800 COMPETITIVE LEGISLATION THROUGH. 1388 00:48:36,800 --> 00:48:38,360 SENATE PASSED THEIR BILL IN 1389 00:48:38,360 --> 00:48:38,560 JUNE. 1390 00:48:38,560 --> 00:48:39,400 HOUSE JUST PASSED THEIR BILL 1391 00:48:39,400 --> 00:48:40,280 LAST WEEK. 1392 00:48:40,280 --> 00:48:42,000 WE'LL BE WATCHING THAT CLOSELY. 1393 00:48:42,000 --> 00:48:48,000 I'M GOING TO TOUCH ON CURES 2.0, 1394 00:48:48,000 --> 00:48:50,160 ARPA-H, AND THEN PREVENT 1395 00:48:50,160 --> 00:48:50,880 PANDEMICS LEGISLATION THE SENATE 1396 00:48:50,880 --> 00:48:52,080 HEALTH COMMITTEE HAS BEEN 1397 00:48:52,080 --> 00:48:55,160 WORKING ON. 1398 00:48:55,160 --> 00:48:58,120 NEXT SLIDE PLEASE. 1399 00:48:58,120 --> 00:48:59,240 SO FY 22 APPROPRIATIONS, THESE 1400 00:48:59,240 --> 00:48:59,960 ARE THE NUMBERS. 1401 00:48:59,960 --> 00:49:01,920 THIS IS WHAT THINGS LOOK LIKE 1402 00:49:01,920 --> 00:49:02,240 RIGHT NOW. 1403 00:49:02,240 --> 00:49:06,240 THE C.R. THAT THE HOUSE PASSED 1404 00:49:06,240 --> 00:49:07,720 EARLIER THIS WEEK, TUESDAY 1405 00:49:07,720 --> 00:49:09,480 NIGHT, WILL TAKE US THROUGH 1406 00:49:09,480 --> 00:49:10,280 MARCH 11. 1407 00:49:10,280 --> 00:49:13,320 CURRENTLY WE'RE UNDER C.R. THAT 1408 00:49:13,320 --> 00:49:15,040 EXPIRES ON FEBRUARY 18. 1409 00:49:15,040 --> 00:49:16,040 SENATOR SCHUMER SAID EARLIER 1410 00:49:16,040 --> 00:49:17,400 TODAY THE SENATE WILL VOTE ON 1411 00:49:17,400 --> 00:49:20,720 THE C.R. NEXT WEEK. 1412 00:49:20,720 --> 00:49:22,840 HOPEFULLY THAT WILL BE SMOOTH 1413 00:49:22,840 --> 00:49:24,200 SAILING. 1414 00:49:24,200 --> 00:49:26,360 THERE WAS A BIT OF A -- SOME 1415 00:49:26,360 --> 00:49:29,200 REPORTING THIS MORNING ABOUT 1416 00:49:29,200 --> 00:49:31,040 SOME CONCERNS SENATOR BLACKBURN 1417 00:49:31,040 --> 00:49:34,200 FROM TENNESSEE RAISED ABOUT 1418 00:49:34,200 --> 00:49:36,760 SAMHSA PROGRAM, HARM REDUCTION 1419 00:49:36,760 --> 00:49:37,080 PROGRAM. 1420 00:49:37,080 --> 00:49:37,960 SENATOR SCHUMER SOUNDED 1421 00:49:37,960 --> 00:49:39,480 CONFIDENT ABOUT THE VOTE NEXT 1422 00:49:39,480 --> 00:49:40,160 WEEK. 1423 00:49:40,160 --> 00:49:42,200 AGAIN, IT'S A 50-50 SENATE SO HE 1424 00:49:42,200 --> 00:49:44,840 NEEDS BIPARTISAN SUPPORT TO GET 1425 00:49:44,840 --> 00:49:45,280 ANYTHING PASSED. 1426 00:49:45,280 --> 00:49:47,080 THESE ARE THE NUMBERS PROPOSED 1427 00:49:47,080 --> 00:49:48,200 IN THE PRESIDENT'S BUDGET. 1428 00:49:48,200 --> 00:49:51,160 IN THE HOUSE BILL THAT WAS 1429 00:49:51,160 --> 00:49:52,480 PASSED IN JULY, SENATE DID NOT 1430 00:49:52,480 --> 00:49:55,160 ACTUALLY PASS A BILL OUT OF 1431 00:49:55,160 --> 00:49:55,400 COMMITTEE. 1432 00:49:55,400 --> 00:49:56,040 MAJORITY RELEASED THEIR DRAFT 1433 00:49:56,040 --> 00:49:56,240 BILL. 1434 00:49:56,240 --> 00:49:58,040 THEY DIDN'T HAVE THE VOTES TO 1435 00:49:58,040 --> 00:49:59,000 GET THE BILLS THROUGH 1436 00:49:59,000 --> 00:49:59,440 SUBCOMMITTEE. 1437 00:49:59,440 --> 00:50:02,400 BUT THESE ARE THE NUMBERS WE'RE 1438 00:50:02,400 --> 00:50:05,920 LOOKING AT FOR NIH, FOR ARPA-H, 1439 00:50:05,920 --> 00:50:07,080 AND FOR NCI. 1440 00:50:07,080 --> 00:50:08,840 SO WE WILL BE WATCHING THIS 1441 00:50:08,840 --> 00:50:09,440 CLOSELY. 1442 00:50:09,440 --> 00:50:11,880 AND HOPEFULLY WE WILL HAVE A 1443 00:50:11,880 --> 00:50:13,360 C.R. THROUGH MARCH 11 BY SOME 1444 00:50:13,360 --> 00:50:17,320 TIME NEXT WEEK SO WE CANNOT GO 1445 00:50:17,320 --> 00:50:18,920 THROUGH THE PREPARATION FOR A 1446 00:50:18,920 --> 00:50:20,560 SHUTDOWN THAT'S SO OFTEN THE 1447 00:50:20,560 --> 00:50:22,520 CASE THAT HAPPENS WITH THESE 1448 00:50:22,520 --> 00:50:25,120 LONG -- WITH THE CRs THAT GO 1449 00:50:25,120 --> 00:50:29,280 RIGHT TO THE ELEVENTH HOUR. 1450 00:50:29,280 --> 00:50:30,280 NEXT SLIDE PLEASE. 1451 00:50:30,280 --> 00:50:33,560 WHEN I SAID WE'RE ALMOST OUT OF 1452 00:50:33,560 --> 00:50:36,040 THE WOODS I THINK A LOT OF THE 1453 00:50:36,040 --> 00:50:38,400 MOMENTUM IN GETTING TO THE NEWS 1454 00:50:38,400 --> 00:50:41,360 WE HEARD LAST NIGHT, THAT THE 1455 00:50:41,360 --> 00:50:43,440 SENATE AND HOUSE AGREED ON 1456 00:50:43,440 --> 00:50:47,600 PARITY, THEY CAME UP WITH AN 1457 00:50:47,600 --> 00:50:48,200 ACCEPTABLE SOLUTION, REPUBLICANS 1458 00:50:48,200 --> 00:50:51,680 WANTED THERE TO BE PARITY WITH 1459 00:50:51,680 --> 00:50:53,360 DEFENSE AND NON-DEFENSE 1460 00:50:53,360 --> 00:50:54,040 SPENDING. 1461 00:50:54,040 --> 00:50:56,400 THE PRESIDENT'S BUDGET DID NOT 1462 00:50:56,400 --> 00:50:58,120 PROPOSE A LARGE INCREASE, IT WAS 1463 00:50:58,120 --> 00:50:59,360 2% INCREASE FOR DEFENSE, THE 1464 00:50:59,360 --> 00:51:01,200 HOUSE WENT A LITTLE HIGHER, 1465 00:51:01,200 --> 00:51:03,520 SENATE WENT HIGHER THAN THAT. 1466 00:51:03,520 --> 00:51:04,600 IT'S AN ISSUE. 1467 00:51:04,600 --> 00:51:07,880 AND THAT WAS A DEAL-BREAKING 1468 00:51:07,880 --> 00:51:09,200 ISSUE WITH POLICY WRITERS THAT 1469 00:51:09,200 --> 00:51:12,160 DEMOCRATS PUT INTO THE HOUSE 1470 00:51:12,160 --> 00:51:12,480 BILL. 1471 00:51:12,480 --> 00:51:14,920 IT REALLY -- THERE WASN'T A LOT 1472 00:51:14,920 --> 00:51:17,840 OF PROGRESS FOR MONTHS. 1473 00:51:17,840 --> 00:51:21,000 THAT WAS REALLY BECAUSE CONGRESS 1474 00:51:21,000 --> 00:51:23,040 WAS VERY OCCUPIED WORKING ON THE 1475 00:51:23,040 --> 00:51:24,000 INFRASTRUCTURE BILL THAT WAS 1476 00:51:24,000 --> 00:51:27,000 PASSED AND SIGNED INTO LAW. 1477 00:51:27,000 --> 00:51:29,200 AND THE BUILD BACK BETTER SOCIAL 1478 00:51:29,200 --> 00:51:29,960 INFRASTRUCTURE LEGISLATION THAT 1479 00:51:29,960 --> 00:51:31,880 AS I THINK EVERYONE KNOWS HAS 1480 00:51:31,880 --> 00:51:34,480 BEEN SORT OF PUT ON HOLD FOR A 1481 00:51:34,480 --> 00:51:34,800 BIT. 1482 00:51:34,800 --> 00:51:37,680 THEY MAY NEED TO HAVE ANOTHER GO 1483 00:51:37,680 --> 00:51:41,600 AT THAT AND REWORK IT INTO A 1484 00:51:41,600 --> 00:51:42,160 PACKAGE THAT IS -- THEY ARE 1485 00:51:42,160 --> 00:51:44,200 GOING TO BE ABLE TO GET THE 1486 00:51:44,200 --> 00:51:45,560 VOTES TO PASS. 1487 00:51:45,560 --> 00:51:48,040 BUT APPROPRIATIONS, THE WHOLE 1488 00:51:48,040 --> 00:51:49,240 SPENDING PROCESS WAS SORT OF 1489 00:51:49,240 --> 00:51:51,760 COLLATERAL DAMAGE TO JUST THERE 1490 00:51:51,760 --> 00:51:52,920 WAS NOT THE ATTENTION AND ENERGY 1491 00:51:52,920 --> 00:51:55,960 ABLE TO BE PUT FORWARD TOWARDS 1492 00:51:55,960 --> 00:51:58,200 APPROPRIATIONS THEN BECAUSE 1493 00:51:58,200 --> 00:52:01,960 THESE WERE SUCH LARGE ISSUES, A 1494 00:52:01,960 --> 00:52:03,920 BIG PRIORITY FOR CONGRESS. 1495 00:52:03,920 --> 00:52:05,320 TWO RETIRING SENATE, CHAIR OF 1496 00:52:05,320 --> 00:52:08,600 THE SENATE FULL APPROPRIATIONS 1497 00:52:08,600 --> 00:52:11,000 COMMITTEE AND RANKING MEMBER, 1498 00:52:11,000 --> 00:52:12,560 PATRICK LEAHY FROM VERMONT, 1499 00:52:12,560 --> 00:52:14,280 RICHARD SHELBY FROM ALABAMA, 1500 00:52:14,280 --> 00:52:17,680 WORKED TOGETHER FOR 36 YEARS. 1501 00:52:17,680 --> 00:52:19,120 AND KNOW HOW TO MAKE A DEAL. 1502 00:52:19,120 --> 00:52:20,240 THEY HAVE PUT A LOT OF ENERGY 1503 00:52:20,240 --> 00:52:21,440 INTO THIS. 1504 00:52:21,440 --> 00:52:22,840 I THINK THAT WE'VE BEEN 1505 00:52:22,840 --> 00:52:24,040 OPTIMISTIC THAT THEY WOULD WANT 1506 00:52:24,040 --> 00:52:27,880 TO GET THIS DONE IN THEIR FINAL 1507 00:52:27,880 --> 00:52:29,360 CONGRESS, AND THERE ARE EARMARKS 1508 00:52:29,360 --> 00:52:30,800 IN THESE SPENDING BILLS FOR THE 1509 00:52:30,800 --> 00:52:32,480 FIRST TIME IN OVER TEN YEARS. 1510 00:52:32,480 --> 00:52:34,880 SO THERE'S A LOT OF INCENTIVE TO 1511 00:52:34,880 --> 00:52:36,480 WANT TO GET THESE BILLS DONE SO 1512 00:52:36,480 --> 00:52:38,840 I THINK WE CAN BE CAUTIOUSLY 1513 00:52:38,840 --> 00:52:43,280 OPTIMISTIC AT THIS POINT. 1514 00:52:43,280 --> 00:52:45,800 NEXT SLIDE PLEASE. 1515 00:52:45,800 --> 00:52:50,600 SO CURES 2.0, DIANA DEGETTE OF 1516 00:52:50,600 --> 00:52:53,000 COLORADO AND FRED UPTON OF 1517 00:52:53,000 --> 00:52:54,600 MICHIGAN INTRODUCED H.R. 6,000 1518 00:52:54,600 --> 00:52:56,480 IN NOVEMBER OF 2021. 1519 00:52:56,480 --> 00:53:00,080 IT COVERS WIDE RANGE OF ISSUES 1520 00:53:00,080 --> 00:53:02,720 INCLUDING TELEHEALTH, IT WOULD 1521 00:53:02,720 --> 00:53:04,880 ESTABLISH ARPA-H WITHIN THE NIH. 1522 00:53:04,880 --> 00:53:09,920 THERE'S OTHER LEGISLATION 1523 00:53:09,920 --> 00:53:11,000 INTRODUCED BY CONGRESSWOMAN ANNA 1524 00:53:11,000 --> 00:53:14,000 ESHU, IN THE HOUSE, HER BILL 1525 00:53:14,000 --> 00:53:16,240 WOULD ESTABLISH ARPA-H WITHIN 1526 00:53:16,240 --> 00:53:16,680 HHS. 1527 00:53:16,680 --> 00:53:19,000 AND SO THERE'S PROBABLY PEOPLE 1528 00:53:19,000 --> 00:53:22,400 ARE -- IT'S FAIRLY COMMON 1529 00:53:22,400 --> 00:53:24,440 KNOWLEDGE THERE'S A SPLIT OF 1530 00:53:24,440 --> 00:53:25,440 OPINION WHERE ARPA-H SHOULD BE 1531 00:53:25,440 --> 00:53:27,960 WITHIN NIH OR OUTSIDE OF NIH. 1532 00:53:27,960 --> 00:53:30,240 IT IS PROPOSED IN THE 1533 00:53:30,240 --> 00:53:31,240 PRESIDENT'S BUDGET AS WITHIN 1534 00:53:31,240 --> 00:53:32,200 NIH. 1535 00:53:32,200 --> 00:53:34,520 WE'LL SEE WHAT HAPPENS. 1536 00:53:34,520 --> 00:53:36,720 NEXT SLIDE PLEASE. 1537 00:53:36,720 --> 00:53:39,760 THERE WAS A HEARING IN THE 1538 00:53:39,760 --> 00:53:42,200 ENERGY AND COMMERCE COMMITTEE 1539 00:53:42,200 --> 00:53:43,960 THIS WEEK, ON TUESDAY, BOTH 1540 00:53:43,960 --> 00:53:45,800 DIANA DEGETTE AND FRED UPTON ARE 1541 00:53:45,800 --> 00:53:46,920 ON THAT COMMITTEE. 1542 00:53:46,920 --> 00:53:52,200 THEY CAME AND SPOKE ABOUT 1543 00:53:52,200 --> 00:53:54,400 WORKING WITH CONGRESSWOMAN ESHU 1544 00:53:54,400 --> 00:53:55,960 ABOUT HER LEGISLATION, THERE 1545 00:53:55,960 --> 00:53:59,600 SEEM TO BE POSITIVE STATEMENTS 1546 00:53:59,600 --> 00:54:02,280 FROM ALL THREE MEMBERS WILL 1547 00:54:02,280 --> 00:54:02,960 COMPLEMENTARY LEGISLATION, THEY 1548 00:54:02,960 --> 00:54:05,240 MAY HAVE COME UP WITH 1549 00:54:05,240 --> 00:54:06,120 COMPROMISES. 1550 00:54:06,120 --> 00:54:08,760 WE DON'T KNOW WHAT THE SENATE 1551 00:54:08,760 --> 00:54:14,560 WILL DO WHEN THEY TAKE UP 1552 00:54:14,560 --> 00:54:15,240 LEGISLATION. 1553 00:54:15,240 --> 00:54:16,280 THE HEARING WAS INTERESTING. 1554 00:54:16,280 --> 00:54:23,240 NOT ALL THE WITNESSES SPOKE 1555 00:54:23,240 --> 00:54:24,880 ABOUT -- VOICED AN OPINION WHERE 1556 00:54:24,880 --> 00:54:33,000 ARPA-H SHOULD BE FOR MAXIMUM 1557 00:54:33,000 --> 00:54:36,240 EFFECTIVENESS, THOSE THAT DID 1558 00:54:36,240 --> 00:54:37,360 RULED OF FAVORED INDEPENDENT, 1559 00:54:37,360 --> 00:54:39,080 THE SECRETARY CAN DECIDE HOW THE 1560 00:54:39,080 --> 00:54:39,920 AGENCY WOULD OPERATE. 1561 00:54:39,920 --> 00:54:41,200 WE'LL BE WATCHING AND SEEING 1562 00:54:41,200 --> 00:54:43,640 WHAT HAPPENS WITH THIS 1563 00:54:43,640 --> 00:54:45,440 LEGISLATION IN THE HOUSE. 1564 00:54:45,440 --> 00:54:49,960 BECAUSE THERE IS THIS YEAR MUST 1565 00:54:49,960 --> 00:54:50,720 PASS LEGISLATION, FDA USER FEE 1566 00:54:50,720 --> 00:54:54,800 LEGISLATION HAS TO BE 1567 00:54:54,800 --> 00:54:55,160 REAUTHORIZED. 1568 00:54:55,160 --> 00:54:56,000 PEOPLE SAY PDUFA, THAT'S WHAT 1569 00:54:56,000 --> 00:54:57,880 THEY MEAN, I'M NOT GOING TO READ 1570 00:54:57,880 --> 00:55:03,160 THROUGH THE TITLE OF THE BILL 1571 00:55:03,160 --> 00:55:03,800 NOW. 1572 00:55:03,800 --> 00:55:05,440 IT BECOMES A TARGET OF THINGS 1573 00:55:05,440 --> 00:55:07,280 YOU CAN ATTACH OTHER PIECES OF 1574 00:55:07,280 --> 00:55:08,280 LEGISLATION TO, SO WHEN YOU KNOW 1575 00:55:08,280 --> 00:55:10,280 SOMETHING IS GOING TO BE MOVING, 1576 00:55:10,280 --> 00:55:11,480 ESPECIALLY A LARGE PIECE OF 1577 00:55:11,480 --> 00:55:12,760 LEGISLATION LIKE THAT, THERE'S 1578 00:55:12,760 --> 00:55:14,080 AN OPPORTUNITY FOR OTHER THINGS 1579 00:55:14,080 --> 00:55:15,440 TO MOVE AT THAT TIME TOO. 1580 00:55:15,440 --> 00:55:19,160 AND AS WE START TO GET CLOSER TO 1581 00:55:19,160 --> 00:55:20,280 THE MIDTERM ELECTIONS AND 1582 00:55:20,280 --> 00:55:21,600 DEADLINE TO GET THAT LEGISLATION 1583 00:55:21,600 --> 00:55:31,400 DONE, I THINK THAT'S WHEN WE'LL 1584 00:55:31,400 --> 00:55:35,680 START TO SEE THE CURES 2.0 AND 1585 00:55:35,680 --> 00:55:37,280 OTHER LEGISLATION. 1586 00:55:37,280 --> 00:55:38,080 THE SENATE HEALTH COMMITTEE, 1587 00:55:38,080 --> 00:55:39,960 HEALTH EDUCATION LABOR AND 1588 00:55:39,960 --> 00:55:41,400 PENSIONS COMMUNITY, CHAIRED BY 1589 00:55:41,400 --> 00:55:42,680 SENATOR PATTY MURRAY OF 1590 00:55:42,680 --> 00:55:44,680 WASHINGTON STATE AND RANKING 1591 00:55:44,680 --> 00:55:46,760 MEMBER IS RICHARD BURR OF NORTH 1592 00:55:46,760 --> 00:55:48,280 CAROLINA, THEY HAVE SPENT A LOT 1593 00:55:48,280 --> 00:55:53,080 OF 250EU78 DEVELOPING THIS -- 1594 00:55:53,080 --> 00:55:54,240 TIME DEVELOPING PREVENT 1595 00:55:54,240 --> 00:55:55,640 PANDEMICS ACT, BOTH COMMITTED TO 1596 00:55:55,640 --> 00:55:59,040 TRYING TO FIGURE OUT WHAT WENT 1597 00:55:59,040 --> 00:56:00,680 WRONG, IN TERMS OF BEING 1598 00:56:00,680 --> 00:56:02,000 PREPARED FOR A PANDEMIC LIKE 1599 00:56:02,000 --> 00:56:04,720 COVID AND WHAT WE CAN DO BETTER 1600 00:56:04,720 --> 00:56:06,240 IN THE NEXT -- TO BE BETTER 1601 00:56:06,240 --> 00:56:08,360 PREPARED FOR A FUTURE SITUATION 1602 00:56:08,360 --> 00:56:08,800 LIKE THIS. 1603 00:56:08,800 --> 00:56:10,560 THERE'S A LOT OF CDC PROVISIONS 1604 00:56:10,560 --> 00:56:13,320 IN THE BILL. 1605 00:56:13,320 --> 00:56:14,560 ONE DETAIL IT WOULD REQUIRE CDC 1606 00:56:14,560 --> 00:56:17,400 DIRECTOR TO GO THROUGH SENATE 1607 00:56:17,400 --> 00:56:18,520 CONFIRMATION AS FDA COMMISSIONER 1608 00:56:18,520 --> 00:56:19,520 HAS TO. 1609 00:56:19,520 --> 00:56:22,920 AS THE SECRETARY OF HHS DOES. 1610 00:56:22,920 --> 00:56:24,400 THERE'S ALSO TEXT ABOUT 1611 00:56:24,400 --> 00:56:27,520 COLLABORATIONS WITH NIH AND CDC 1612 00:56:27,520 --> 00:56:28,720 AND STRATEGIC PLANNING FOR CDC, 1613 00:56:28,720 --> 00:56:30,560 BUT WE'LL SEE HOW THAT BILL 1614 00:56:30,560 --> 00:56:32,360 DEVELOPS OVER TIME AND WHAT SORT 1615 00:56:32,360 --> 00:56:33,960 OF INPUT THEY GET. 1616 00:56:33,960 --> 00:56:35,000 THEY ARE ACCEPTING COMMENTS NOW. 1617 00:56:35,000 --> 00:56:36,400 AND THAT'S WHAT THEY ARE LOOKING 1618 00:56:36,400 --> 00:56:36,680 FOR. 1619 00:56:36,680 --> 00:56:38,120 WE'LL START TO SEE THAT MOVE 1620 00:56:38,120 --> 00:56:42,160 TOWARDS LATER IN THE YEAR. 1621 00:56:42,160 --> 00:56:43,280 NEXT SLIDE PLEASE. 1622 00:56:43,280 --> 00:56:46,040 SO THERE ARE A LOT OF 1623 00:56:46,040 --> 00:56:46,360 RETIREMENTS. 1624 00:56:46,360 --> 00:56:49,160 THE HOUSE PRESS GALLERY HAS THIS 1625 00:56:49,160 --> 00:56:51,880 WEBSITE THEY KEEP UPDATED, 1626 00:56:51,880 --> 00:56:55,280 CASUALTY LIST, I MENTIONED 1627 00:56:55,280 --> 00:56:58,280 SENATOR LEAHY AND SENATOR SHELBY 1628 00:56:58,280 --> 00:57:00,480 RETIREMENTS, WE'RE ALSO SEEING 1629 00:57:00,480 --> 00:57:01,800 SENATOR BURR AND SENATOR ROY 1630 00:57:01,800 --> 00:57:04,760 BLUNT, WHO HAS BEEN THE TOP 1631 00:57:04,760 --> 00:57:07,600 REPUBLICAN ON THE APPROPRIATIONS 1632 00:57:07,600 --> 00:57:08,600 SUBCOMMITTEE, LABOR HHS 1633 00:57:08,600 --> 00:57:10,440 APPROPRIATIONS SUBCOMMITTEE FOR 1634 00:57:10,440 --> 00:57:10,720 NIH. 1635 00:57:10,720 --> 00:57:12,200 AND SO THERE'S A LOT OF 1636 00:57:12,200 --> 00:57:13,800 EXPERTISE THAT'S GOING TO BE 1637 00:57:13,800 --> 00:57:15,240 LEAVING THE SENATE IN THESE 1638 00:57:15,240 --> 00:57:15,600 COMMITTEES. 1639 00:57:15,600 --> 00:57:20,400 FOR THE SENATE THERE'S ONLY ONE 1640 00:57:20,400 --> 00:57:22,160 DEMOCRAT, SENATOR LEAHY, 1641 00:57:22,160 --> 00:57:22,640 ANNOUNCED RETIREMENT. 1642 00:57:22,640 --> 00:57:25,200 FOR THE G.O.P. IT'S FIVE 1643 00:57:25,200 --> 00:57:25,960 REPUBLICANS ANNOUNCED 1644 00:57:25,960 --> 00:57:26,320 RETIREMENTS. 1645 00:57:26,320 --> 00:57:30,200 IN THE HOUSE FAR TOO MANY NAMES 1646 00:57:30,200 --> 00:57:32,520 AND PICTURES TO SHOW HERE. 1647 00:57:32,520 --> 00:57:35,400 I SELECTED A FEW MEMBERS FROM 1648 00:57:35,400 --> 00:57:38,320 EACH PARTY WHO HAVE BEEN 1649 00:57:38,320 --> 00:57:39,760 PARTICULARLY ENGAGED WITH NCI 1650 00:57:39,760 --> 00:57:45,000 AND NIH OR HAVE LEADERSHIP 1651 00:57:45,000 --> 00:57:49,480 POSITIONS, JACKIE SPEIR HAS BEEN 1652 00:57:49,480 --> 00:57:52,120 AN ADVOCATE, AS G K BUTTERFIELD, 1653 00:57:52,120 --> 00:57:55,640 REPRESENTATIVE DAVID PRICE FROM 1654 00:57:55,640 --> 00:58:00,840 NORTH CAROLINA, AND 1655 00:58:00,840 --> 00:58:01,320 REPRESENTATIVE LUCILLE 1656 00:58:01,320 --> 00:58:01,840 ROYBAL-ALLARD, KEVIN BRADY 1657 00:58:01,840 --> 00:58:04,400 CHAIRMAN OF WAYS AND MEANS, A 1658 00:58:04,400 --> 00:58:06,800 COMPETITION TO GET THAT JOB 1659 00:58:06,800 --> 00:58:09,560 AFTER HE RETIRES, AND EVERYONE 1660 00:58:09,560 --> 00:58:11,760 KNOW WHO IS ADAM KINZINGER IS, 1661 00:58:11,760 --> 00:58:13,680 HE'S BEEN IN THE NEWS THE LAST 1662 00:58:13,680 --> 00:58:15,240 YEAR OR TWO, STEPPING DOWN FROM 1663 00:58:15,240 --> 00:58:16,200 HIS POSITION. 1664 00:58:16,200 --> 00:58:18,320 SO WE'RE GOING TO SEE A LOT OF 1665 00:58:18,320 --> 00:58:20,400 NEW NAMES AND NEW FACES, AND 1666 00:58:20,400 --> 00:58:22,160 PEOPLE IN LEADERSHIP POSITIONS. 1667 00:58:22,160 --> 00:58:24,560 IT'S NOT JUST THESE MEMBERS 1668 00:58:24,560 --> 00:58:25,400 REPRESENT IMPORTANT INTERESTS 1669 00:58:25,400 --> 00:58:27,600 AND HAVE DONE A LOT OF GREAT 1670 00:58:27,600 --> 00:58:28,160 WORK. 1671 00:58:28,160 --> 00:58:29,560 THEY HAVE ALSO GOT LEADERSHIP 1672 00:58:29,560 --> 00:58:31,840 POSITIONS, WE'LL SEE IN THE NEXT 1673 00:58:31,840 --> 00:58:35,680 CONGRESS RACES TO TAKE THOSE 1674 00:58:35,680 --> 00:58:35,920 GAVELS. 1675 00:58:35,920 --> 00:58:36,600 NEXT SLIDE PLEASE. 1676 00:58:36,600 --> 00:58:38,400 SO THERE'S A LOT OF TIME BETWEEN 1677 00:58:38,400 --> 00:58:39,840 NOW AND THE MIDTERMS, AND WE'LL 1678 00:58:39,840 --> 00:58:41,480 HAVE MORE MEETINGS TO TALK 1679 00:58:41,480 --> 00:58:43,560 ABOUT, WHAT THINGS LOOK LIKE. 1680 00:58:43,560 --> 00:58:47,520 I WANT TO REMIND EVERYONE WHAT 1681 00:58:47,520 --> 00:58:48,480 HISTORY TELLS US. 1682 00:58:48,480 --> 00:58:51,560 THIS IS BY NO MEANS A GUARANTEE, 1683 00:58:51,560 --> 00:58:52,760 BUT THE PRESIDENT'S PARTY WITH 1684 00:58:52,760 --> 00:58:54,960 TWO EXCEPTIONS IN THE PAST 50 1685 00:58:54,960 --> 00:58:57,200 YEARS LOSES SEATS IN THE 1686 00:58:57,200 --> 00:58:57,480 MIDTERMS. 1687 00:58:57,480 --> 00:59:01,560 AND THIS IS WHAT SOME OF THE 1688 00:59:01,560 --> 00:59:02,280 NATIONAL JOURNAL ASSESSMENT OF 1689 00:59:02,280 --> 00:59:06,360 WHAT NUMBERS HAVE LOOKED LIKE IN 1690 00:59:06,360 --> 00:59:09,520 THE HOUSE AND SENATE SINCE 1946. 1691 00:59:09,520 --> 00:59:10,760 NEXT SLIDE PLEASE. 1692 00:59:10,760 --> 00:59:12,480 AND THEN HERE'S ANOTHER SLIDE 1693 00:59:12,480 --> 00:59:14,800 WHERE THEY TOOK A DIFFERENT 1694 00:59:14,800 --> 00:59:15,960 LOOK, LOOKING AT EACH 1695 00:59:15,960 --> 00:59:17,200 PRESIDENCY, WHAT HAPPENS IN THE 1696 00:59:17,200 --> 00:59:20,440 MIDTERMS DURING EACH OF THESE 1697 00:59:20,440 --> 00:59:20,800 PRESIDENCIES. 1698 00:59:20,800 --> 00:59:22,080 I THOUGHT IT WOULD BE 1699 00:59:22,080 --> 00:59:23,840 INTERESTING TO LOOK AT SOME 1700 00:59:23,840 --> 00:59:24,080 DATA. 1701 00:59:24,080 --> 00:59:25,400 THAT'S ALL I HAVE FOR TODAY. 1702 00:59:25,400 --> 00:59:26,800 IF YOU HAVE ANY QUESTIONS I'M 1703 00:59:26,800 --> 00:59:31,840 HAPPY TO TAKE THEM NOW, IF DR. 1704 00:59:31,840 --> 00:59:33,560 CARPTEN SAYS WE CAN DO THAT OR 1705 00:59:33,560 --> 00:59:35,600 GET IN TOUCH WITH ME AND WE CAN 1706 00:59:35,600 --> 00:59:36,800 TALK AT YOUR CONVENIENCE. 1707 00:59:36,800 --> 00:59:38,200 >> THANKS, M.K. 1708 00:59:38,200 --> 00:59:44,360 WE DO HAVE FIVE MINUTES FOR 1709 00:59:44,360 --> 00:59:44,600 QUESTIONS. 1710 00:59:44,600 --> 00:59:47,400 ANY QUESTIONS? 1711 00:59:47,400 --> 00:59:49,920 SO FROM MY PERSPECTIVE, IT WAS 1712 00:59:49,920 --> 00:59:53,600 INTERESTING TO SEE FROM, YOU 1713 00:59:53,600 --> 00:59:57,520 KNOW, THE PROPOSED BUDGETS TO 1714 00:59:57,520 --> 00:59:59,120 SORT OF -- WHAT CURRENTLY COULD 1715 00:59:59,120 --> 01:00:01,320 BE PLANNED, DECREASE IN OVERALL 1716 01:00:01,320 --> 01:00:04,480 NIH, BUT LOOKS LIKE NCI WOULD DO 1717 01:00:04,480 --> 01:00:05,360 PRETTY WELL. 1718 01:00:05,360 --> 01:00:08,080 HOW WOULD THE DECREASE IN THE 1719 01:00:08,080 --> 01:00:09,720 OVERALL NIH BUDGET IMPACT NCI? 1720 01:00:09,720 --> 01:00:11,240 WOULD IT IMPACT NCI AT ALL? 1721 01:00:11,240 --> 01:00:13,880 I DON'T KNOW IF NED WANTS TO 1722 01:00:13,880 --> 01:00:15,520 CHIME IN. 1723 01:00:15,520 --> 01:00:18,760 >> THERE WASN'T -- SO SOME OF 1724 01:00:18,760 --> 01:00:20,000 THE INCREASES PROPOSED WERE NOT 1725 01:00:20,000 --> 01:00:20,760 LARGE. 1726 01:00:20,760 --> 01:00:22,840 THERE WHY NO BUDGET -- THE 1727 01:00:22,840 --> 01:00:23,920 PRESIDENT'S BUDGET, SENATE AND 1728 01:00:23,920 --> 01:00:26,200 HOUSE ALL WOULD INCREASE THE NIH 1729 01:00:26,200 --> 01:00:26,800 BUDGET. 1730 01:00:26,800 --> 01:00:30,960 BUT THERE WERE VERY DIFFERENT 1731 01:00:30,960 --> 01:00:32,600 NUMBERS FOR WHAT ARPA-H WOULD BE 1732 01:00:32,600 --> 01:00:34,440 FUNDED AT AND DIFFERENT NUMBERS 1733 01:00:34,440 --> 01:00:35,200 FOR NCI. 1734 01:00:35,200 --> 01:00:39,000 FOR US, THE HOUSE NUMBER WAS 1735 01:00:39,000 --> 01:00:42,200 INCREASE OF $434 MILLION. 1736 01:00:42,200 --> 01:00:46,360 SENATE NUMBER I WANT TO SAY 212. 1737 01:00:46,360 --> 01:00:47,200 YEAH, 212. 1738 01:00:47,200 --> 01:00:48,520 SO, YEAH, THAT'S A BIG 1739 01:00:48,520 --> 01:00:48,960 DIFFERENCE. 1740 01:00:48,960 --> 01:00:51,040 I DON'T KNOW IF NED WANTS TO 1741 01:00:51,040 --> 01:00:52,280 COMMENT ON THAT, BUT OBVIOUSLY 1742 01:00:52,280 --> 01:00:54,000 THAT'S EXACTLY WHAT WE WERE 1743 01:00:54,000 --> 01:00:55,560 REALLY WORRIED ABOUT WITH THE 1744 01:00:55,560 --> 01:00:57,680 FULL YEAR C.R., AND WE'RE 1745 01:00:57,680 --> 01:00:58,600 ALREADY OVER FOUR MONTHS INTO 1746 01:00:58,600 --> 01:01:00,960 THE C.R. 1747 01:01:00,960 --> 01:01:03,400 YOU KNOW, IT'S LIKE A CUT IN AN 1748 01:01:03,400 --> 01:01:04,000 APPROPRIATION. 1749 01:01:04,000 --> 01:01:06,200 I DON'T KNOW, NED, IF YOU WANTED 1750 01:01:06,200 --> 01:01:07,080 TO COMMENT ON THAT. 1751 01:01:07,080 --> 01:01:08,520 >> THERE'S SORT OF THREE 1752 01:01:08,520 --> 01:01:09,000 VERSIONS. 1753 01:01:09,000 --> 01:01:13,200 THERE'S THE FULL YEAR C.R., A 1754 01:01:13,200 --> 01:01:13,640 DISASTER. 1755 01:01:13,640 --> 01:01:18,440 THERE'S THE $200 MILLION 1756 01:01:18,440 --> 01:01:20,720 INCREASE, AND $400 MILLION FOR 1757 01:01:20,720 --> 01:01:21,080 THE HOUSE. 1758 01:01:21,080 --> 01:01:22,960 $200 MILLION IS A BIG 1759 01:01:22,960 --> 01:01:23,240 DIFFERENCE. 1760 01:01:23,240 --> 01:01:24,600 BY THE WAY, CONGRESS COULD DO 1761 01:01:24,600 --> 01:01:26,320 SOMETHING DIFFERENT FROM ALL 1762 01:01:26,320 --> 01:01:27,120 THREE OF THOSE. 1763 01:01:27,120 --> 01:01:28,720 NONE OF THOSE THINGS ARE 1764 01:01:28,720 --> 01:01:29,680 BINDING. 1765 01:01:29,680 --> 01:01:30,920 SO WE WILL HAVE TO WAIT AND SEE 1766 01:01:30,920 --> 01:01:32,400 WHAT HAPPENS. 1767 01:01:32,400 --> 01:01:33,560 AS M.K. SAID, IT'S GREAT NEWS 1768 01:01:33,560 --> 01:01:35,200 THAT THEY ARE FINALLY AT LEAST 1769 01:01:35,200 --> 01:01:36,720 AGREES ON TOP LINE NUMBERS, THE 1770 01:01:36,720 --> 01:01:38,600 FIRST THING THAT HAS TO HAPPEN. 1771 01:01:38,600 --> 01:01:39,120 >> YEAH, CHRIS? 1772 01:01:39,120 --> 01:01:40,680 I SEE YOUR HAND UP. 1773 01:01:40,680 --> 01:01:42,800 >> THANKS, JOHN. 1774 01:01:42,800 --> 01:01:44,240 M.K., THANKS FOR ALL YOUR TEAM 1775 01:01:44,240 --> 01:01:46,480 DOES IN THIS CHALLENGING TIME. 1776 01:01:46,480 --> 01:01:49,840 ARPA-H, MY UNDERSTANDING IS 1777 01:01:49,840 --> 01:01:51,520 THERE'S NOT SENATE -- OR OPEN 1778 01:01:51,520 --> 01:01:53,560 DISCUSSION YET, IS THAT CORRECT? 1779 01:01:53,560 --> 01:01:54,840 I HAVEN'T SEEN ANYTHING IN THE 1780 01:01:54,840 --> 01:01:56,040 SENATE IN TERMS OF PEOPLE 1781 01:01:56,040 --> 01:01:58,120 WEIGHING IN ON HHS VERSUS NIH 1782 01:01:58,120 --> 01:02:01,600 LOCATION AND THINGS LIKE THAT. 1783 01:02:01,600 --> 01:02:01,920 >> RIGHT. 1784 01:02:01,920 --> 01:02:04,680 YEAH, THERE'S -- WE HAVEN'T SEEN 1785 01:02:04,680 --> 01:02:05,800 LEGISLATION INTRODUCED. 1786 01:02:05,800 --> 01:02:06,760 WE MAY NOT. 1787 01:02:06,760 --> 01:02:13,560 IT MAY BE PART OF A CURES 1788 01:02:13,560 --> 01:02:14,240 NEGOTIATION. 1789 01:02:14,240 --> 01:02:16,560 WE'VE SEEN SOME -- POLITICAL 1790 01:02:16,560 --> 01:02:17,360 REPORTERS WILL ASK MEMBERS AS 1791 01:02:17,360 --> 01:02:18,680 SOON AS THE PRESIDENT'S BUDGET 1792 01:02:18,680 --> 01:02:22,080 COMES OUT, AND THEY SORT OF MAKE 1793 01:02:22,080 --> 01:02:22,520 THE PITCH. 1794 01:02:22,520 --> 01:02:23,800 AND, YOU KNOW, ARPA-H I'M SURE 1795 01:02:23,800 --> 01:02:25,800 THERE WILL BE QUESTIONS ABOUT 1796 01:02:25,800 --> 01:02:29,520 IT, AT A VARIETY OF 1797 01:02:29,520 --> 01:02:30,160 APPROPRIATIONS HEARINGSING FORS 1798 01:02:30,160 --> 01:02:32,440 FY23, WHICH I THINK WE EXPECT TO 1799 01:02:32,440 --> 01:02:34,000 BE HAPPENING LATE MARCH INTO 1800 01:02:34,000 --> 01:02:34,560 APRIL. 1801 01:02:34,560 --> 01:02:36,520 STATE OF THE UNION IS -- IT WILL 1802 01:02:36,520 --> 01:02:38,240 BE AFTER THAT THE PRESIDENT'S 1803 01:02:38,240 --> 01:02:40,080 BUDGET IS RELEASED SO SOMETIME 1804 01:02:40,080 --> 01:02:41,160 IN MARCH. 1805 01:02:41,160 --> 01:02:42,320 SO, YEAH, WE'LL SEE. 1806 01:02:42,320 --> 01:02:46,000 I THINK THE SENATE IS SORT OF -- 1807 01:02:46,000 --> 01:02:48,320 HAS NOT ENTERED INTO THE 1808 01:02:48,320 --> 01:02:49,600 SPECIFIC DISCUSSIONS ABOUT WHEN 1809 01:02:49,600 --> 01:02:52,560 AND WHERE THERE'S BEEN SOME 1810 01:02:52,560 --> 01:02:54,600 BRIEFINGS THAT ARE, YOU KNOW, 1811 01:02:54,600 --> 01:02:59,880 HIGH LEVEL BRIEFINGS WE'VE HEARD 1812 01:02:59,880 --> 01:03:00,080 ABOUT. 1813 01:03:00,080 --> 01:03:02,280 I THINK THERE WILL BE INTEREST 1814 01:03:02,280 --> 01:03:03,160 IN SUPPORTING SOMETHING THE 1815 01:03:03,160 --> 01:03:04,600 PRESIDENT IS PROPOSING THAT'S AN 1816 01:03:04,600 --> 01:03:06,760 IMPORTANT PART OF HIS FY23 1817 01:03:06,760 --> 01:03:08,360 BUDGET AND SO WE'LL SEE WHERE IT 1818 01:03:08,360 --> 01:03:08,560 GOES. 1819 01:03:08,560 --> 01:03:09,800 I IMAGINE THERE WAS HOPE WE 1820 01:03:09,800 --> 01:03:11,560 WOULD BE FURTHER ALONG BY THIS 1821 01:03:11,560 --> 01:03:13,520 POINT IN TIME. 1822 01:03:13,520 --> 01:03:15,400 BUT THAT IS ALSO PROBABLY A 1823 01:03:15,400 --> 01:03:16,960 FACTOR OF JUST APPROPRIATIONS 1824 01:03:16,960 --> 01:03:20,320 BEING SO DELAYED THIS YEAR. 1825 01:03:20,320 --> 01:03:21,240 >> THANK YOU. 1826 01:03:21,240 --> 01:03:25,000 >> WELL, THANKS, M.K. 1827 01:03:25,000 --> 01:03:25,320 IT'S GREAT. 1828 01:03:25,320 --> 01:03:27,640 I'M SURE ALL OF US WILL KEEP 1829 01:03:27,640 --> 01:03:30,840 EYES AND EARS OPEN AND HOPEFULLY 1830 01:03:30,840 --> 01:03:33,120 SEE MOVING TOWARDS AN ACTUAL 1831 01:03:33,120 --> 01:03:36,200 BUDGET IN THE NOT TOO DISTANT 1832 01:03:36,200 --> 01:03:36,800 FUTURE. 1833 01:03:36,800 --> 01:03:38,280 WE'RE A MINUTE AHEAD, WHICH IS 1834 01:03:38,280 --> 01:03:38,600 GOOD. 1835 01:03:38,600 --> 01:03:42,640 NEXT UP IS THE ANNUAL DELEGATION 1836 01:03:42,640 --> 01:03:51,800 ALSO OF AUTHORITY BY DR. GRAY. 1837 01:03:51,800 --> 01:03:52,040 PAULETTE? 1838 01:03:52,040 --> 01:03:53,000 >> THANKS, JOHN. 1839 01:03:53,000 --> 01:03:55,160 I'LL MAKE THIS AS UNBORING, 1840 01:03:55,160 --> 01:03:57,880 NON-BORING AS POSSIBLE. 1841 01:03:57,880 --> 01:03:58,360 OKAY? 1842 01:03:58,360 --> 01:04:01,360 BUT DELEGATIONS OF AUTHORITY 1843 01:04:01,360 --> 01:04:04,160 ALLOWS THE NCI TO FUNCTION IN 1844 01:04:04,160 --> 01:04:06,200 CERTAIN WAYS WITHOUT COMING TO 1845 01:04:06,200 --> 01:04:08,200 THE BOARD FOR EACH ISSUE. 1846 01:04:08,200 --> 01:04:10,720 SPECIFICALLY, THERE ARE TWO 1847 01:04:10,720 --> 01:04:13,800 DELEGATIONS, AND THESE 1848 01:04:13,800 --> 01:04:20,000 DELEGATIONS ARE TO NCI DIRECTOR. 1849 01:04:20,000 --> 01:04:22,440 AND THE FIRST DELEGATION ALLOWS 1850 01:04:22,440 --> 01:04:25,480 THE NCI DIRECTOR TO OBTAIN 1851 01:04:25,480 --> 01:04:27,440 PERMISSION IN ACCORDANCE WITH 1852 01:04:27,440 --> 01:04:32,960 SECTION 413B OF THE PUBLIC 1853 01:04:32,960 --> 01:04:35,640 HEALTH SERVICE ACT AND SECTION 1854 01:04:35,640 --> 01:04:37,960 3109 UNITED STATES TITLE CODE TO 1855 01:04:37,960 --> 01:04:42,640 OBTAIN THE SERVICES OF NOT MORE 1856 01:04:42,640 --> 01:04:44,080 THAN 151 SPECIAL EXPERTS OR 1857 01:04:44,080 --> 01:04:48,800 CONSULT I ANTS WHO HAVE 1858 01:04:48,800 --> 01:04:49,920 QUALIFICATIONS TO ASSIST IN 1859 01:04:49,920 --> 01:04:54,040 ACCOMPLISHING THE MISSION OF THE 1860 01:04:54,040 --> 01:04:54,640 INSTITUTE. 1861 01:04:54,640 --> 01:04:58,440 DON'T ASK ME WHERE THE NUMBER 1862 01:04:58,440 --> 01:05:00,320 151 CAME FROM. 1863 01:05:00,320 --> 01:05:01,000 I'VE LOOKED. 1864 01:05:01,000 --> 01:05:03,120 I'VE NOT BEEN ABLE TO ASCERTAIN 1865 01:05:03,120 --> 01:05:07,000 HOW THEY CAME UP WITH THE NUMBER 1866 01:05:07,000 --> 01:05:07,840 151. 1867 01:05:07,840 --> 01:05:11,480 NOR ARE WE COUNTING. 1868 01:05:11,480 --> 01:05:15,000 SO DELEGATION B PROVIDES THE NCI 1869 01:05:15,000 --> 01:05:16,760 DIRECTOR THE PERMISSION TO 1870 01:05:16,760 --> 01:05:23,000 EXERCISE AUTHORITY AS STATED IN 1871 01:05:23,000 --> 01:05:24,560 SECTION 413B OF THE PUBLIC 1872 01:05:24,560 --> 01:05:25,840 SERVICE HEALTH ACT TO APPOINT 1873 01:05:25,840 --> 01:05:28,240 ONE OR MORE ADVISORY COMMITTEES, 1874 01:05:28,240 --> 01:05:30,600 COMPOSED OF SUCH PRIVATE 1875 01:05:30,600 --> 01:05:31,760 CITIZENS AND OFFICIALS OF 1876 01:05:31,760 --> 01:05:34,400 FEDERAL, STATE, AND LOCAL 1877 01:05:34,400 --> 01:05:38,520 GOVERNMENTS TO ADVISE HIM WITH 1878 01:05:38,520 --> 01:05:40,120 RESPECT TO THE DIRECTOR'S 1879 01:05:40,120 --> 01:05:40,600 FUNCTIONS. 1880 01:05:40,600 --> 01:05:44,200 I'M GOING TO SHIFT TO STATEMENTS 1881 01:05:44,200 --> 01:05:49,800 OF UNDERSTANDING THAT THE BOARD 1882 01:05:49,800 --> 01:05:51,440 WILL HAVE WITH THE NATIONAL 1883 01:05:51,440 --> 01:05:55,920 CANCER INSTITUTE STAFF. 1884 01:05:55,920 --> 01:05:57,800 SPECIFICALLY, AND THIS IS IN 1885 01:05:57,800 --> 01:06:05,000 ACCORDANCE WITH NIH'S MANUAL 1886 01:06:05,000 --> 01:06:06,640 ISSUANCE 4513, RECOMMENDATION OF 1887 01:06:06,640 --> 01:06:12,200 INITIAL REVIEW GROUPS WILL BE 1888 01:06:12,200 --> 01:06:14,280 REQUIRED WITH EXCEPTION OF 1889 01:06:14,280 --> 01:06:19,480 TRAINING GRANTS, FELLOWSHIPS, 1890 01:06:19,480 --> 01:06:20,400 OTHER NON-RESEARCH GRANT 1891 01:06:20,400 --> 01:06:22,120 APPLICATIONS AND NOT PROPOSALS 1892 01:06:22,120 --> 01:06:26,360 TO CONDUCT OR SUPPORT RESEARCH. 1893 01:06:26,360 --> 01:06:28,480 THESE GRANTS, FELLOWSHIPS, ET 1894 01:06:28,480 --> 01:06:34,120 CETERA, ARE NOT SUBJECT TO NCAB 1895 01:06:34,120 --> 01:06:36,360 REVIEW AND APPROVAL WITHOUT 1896 01:06:36,360 --> 01:06:38,040 OTHER CONCERNS. 1897 01:06:38,040 --> 01:06:39,240 IF THERE ARE CONCERNS, THOSE 1898 01:06:39,240 --> 01:06:41,520 GRANTS WILL NOT BE AWARDED 1899 01:06:41,520 --> 01:06:43,600 UNLESS THEY ARE ACTUALLY BROUGHT 1900 01:06:43,600 --> 01:06:53,360 TO THE ATTENTION OF THE NCAB. 1901 01:06:53,360 --> 01:06:54,720 SPECIFICALLY RUTH KIRSCHSTEIN 1902 01:06:54,720 --> 01:06:57,280 SERVICE AWARDS, THOSE MUST COME 1903 01:06:57,280 --> 01:07:01,400 TO THE NCAB FOR YOUR 1904 01:07:01,400 --> 01:07:01,720 CONSIDERATION. 1905 01:07:01,720 --> 01:07:03,440 APPLICATIONS OVER THE 20th 1906 01:07:03,440 --> 01:07:05,000 PERCENTILE WILL NOT HAVE SUMMARY 1907 01:07:05,000 --> 01:07:08,600 STATEMENTS PRESENTED TO THE NCAB 1908 01:07:08,600 --> 01:07:09,200 UNLESS THE INSTITUTE IS 1909 01:07:09,200 --> 01:07:16,280 CONSIDERING THE AWARD OF SUCH AN 1910 01:07:16,280 --> 01:07:16,800 APPLICATION. 1911 01:07:16,800 --> 01:07:20,440 SPECIAL CONSIDERATION BY AN 1912 01:07:20,440 --> 01:07:23,800 APPOINTED NUMBER OF THE BOARD 1913 01:07:23,800 --> 01:07:28,080 WILL BE TAKEN INTO CONSIDERATION 1914 01:07:28,080 --> 01:07:28,840 AND FOR APPLICATIONS ASSIGNED 1915 01:07:28,840 --> 01:07:31,600 RAW SCORES THAT ARE NOT 1916 01:07:31,600 --> 01:07:34,400 PERCENTILE, THE CUTOFF WILL BE 1917 01:07:34,400 --> 01:07:39,480 AN IMPACT SCORE OF FIFTY, EXCEPT 1918 01:07:39,480 --> 01:07:45,160 FOR R 41, 42s, 43s, AND R 44 1919 01:07:45,160 --> 01:07:45,720 AWARDS. 1920 01:07:45,720 --> 01:07:50,320 ALL SCORED APPLICATIONS WILL BE 1921 01:07:50,320 --> 01:07:53,760 INCLUDED AND I'M SWITCHING NOW 1922 01:07:53,760 --> 01:07:56,480 TO EXPEDITED CONCURRENCE. 1923 01:07:56,480 --> 01:07:59,440 FOR R01 AN R21 APPLICATIONS, 1924 01:07:59,440 --> 01:08:03,480 EXCLUDING THOSE FROM FOREIGN 1925 01:08:03,480 --> 01:08:04,200 ORGANIZATIONS, WITH PERCENTILE 1926 01:08:04,200 --> 01:08:07,200 SCORES THAT FALL IN THE NCI PAY 1927 01:08:07,200 --> 01:08:09,400 LINES FOR THAT MECHANISM, THAT 1928 01:08:09,400 --> 01:08:15,040 HAVE NO CONCERNS NOTED THAT 1929 01:08:15,040 --> 01:08:18,800 WOULD REPRESENT, FOR EXAMPLE 1930 01:08:18,800 --> 01:08:21,240 HUMAN SUBJECTS, ANIMAL WELFARE, 1931 01:08:21,240 --> 01:08:24,200 HAZARDS, INCLUSION OF WOMEN, 1932 01:08:24,200 --> 01:08:27,240 CHILDREN, APPROPRIATE MINORITY 1933 01:08:27,240 --> 01:08:27,960 DISTRIBUTION. 1934 01:08:27,960 --> 01:08:30,320 THE REVIEWERS WILL CONSIST OF 1935 01:08:30,320 --> 01:08:34,120 THE CHAIR OF THE SUBCOMMITTEE ON 1936 01:08:34,120 --> 01:08:36,000 SPECIAL ACTIONS WHICH IS 1937 01:08:36,000 --> 01:08:39,280 FRANCIS, AND TWO ADDITIONAL NCAB 1938 01:08:39,280 --> 01:08:42,800 MEMBERS WILL BE APPOINTED TO 1939 01:08:42,800 --> 01:08:45,800 THAT SUBCOMMITTEE TO EXPEDITE 1940 01:08:45,800 --> 01:08:47,720 THESE GRANTS. 1941 01:08:47,720 --> 01:08:51,400 IN OTHER WORDS, IF THOSE R01 1942 01:08:51,400 --> 01:08:53,480 GRANTS THAT FALL WITHIN A 1943 01:08:53,480 --> 01:08:55,120 CERTAIN PERCENTILE BASED ON NCI 1944 01:08:55,120 --> 01:08:59,400 PAY LINE, THOSE WILL NOT COME TO 1945 01:08:59,400 --> 01:09:01,600 THIS BOARD, THEY WILL 1946 01:09:01,600 --> 01:09:03,240 AUTOMATICALLY BE INCLUDED IN THE 1947 01:09:03,240 --> 01:09:05,000 EN BLOC. 1948 01:09:05,000 --> 01:09:05,400 OKAY? 1949 01:09:05,400 --> 01:09:06,960 IN CASES OF EMERGING NEED AS 1950 01:09:06,960 --> 01:09:12,840 DETERMINED BY THE DIRECTOR OF 1951 01:09:12,840 --> 01:09:16,000 NCI, EXPEDITED CONCURRENCE MAY 1952 01:09:16,000 --> 01:09:20,160 BE UTILIZED FOR SINGLE CASE 1953 01:09:20,160 --> 01:09:22,040 DEVIATIONS. 1954 01:09:22,040 --> 01:09:23,760 THOSE SINGLE CASE DEVIATIONS 1955 01:09:23,760 --> 01:09:27,840 WILL BE REPORTED TO THE BOARD IF 1956 01:09:27,840 --> 01:09:29,480 THAT OCCURS. 1957 01:09:29,480 --> 01:09:30,240 ELECTRONIC CONCURRENCE MINIMUM 1958 01:09:30,240 --> 01:09:33,760 OF TWO NUMBERS WITH NO VOTES FOR 1959 01:09:33,760 --> 01:09:35,800 NON-CONCURRENCE MUST OCCUR 1960 01:09:35,800 --> 01:09:38,240 WITHIN SEVEN DAYS OF 1961 01:09:38,240 --> 01:09:42,000 NOTIFICATION OF POSTING IS 1962 01:09:42,000 --> 01:09:50,240 REQUIRED FOR APPROVAL AND THOSE 1963 01:09:50,240 --> 01:09:52,400 POSTINGS GIVEN TO THIS 1964 01:09:52,400 --> 01:09:54,360 SUBCOMMITTEE VIA ELECTRONIC 1965 01:09:54,360 --> 01:09:56,680 COUNCIL BOOK, NOT SOMETHING 1966 01:09:56,680 --> 01:09:58,400 THAT'S DONE VIA E-MAIL. 1967 01:09:58,400 --> 01:09:59,600 A SINGLE VOTE FOR 1968 01:09:59,600 --> 01:10:00,440 NON-CONCURRENCE IN ALLOTTED TIME 1969 01:10:00,440 --> 01:10:03,760 PERIOD WILL RESULT IN THAT 1970 01:10:03,760 --> 01:10:04,400 APPLICATION GOING FOR REGULAR 1971 01:10:04,400 --> 01:10:08,560 CONSIDERATION TO THE BOARD UNDER 1972 01:10:08,560 --> 01:10:14,160 ITS STANDARD PROCEDURE BUT 1973 01:10:14,160 --> 01:10:15,680 NON-EXPEDITED APPLICATION. 1974 01:10:15,680 --> 01:10:18,600 LACKING VOTES WILL BE PRESENTED 1975 01:10:18,600 --> 01:10:20,880 TO THE FULL NCAB AT REGULAR 1976 01:10:20,880 --> 01:10:21,240 MEETING. 1977 01:10:21,240 --> 01:10:27,880 NOW MOVING TO ADMINISTRATIVE 1978 01:10:27,880 --> 01:10:29,120 ADJUSTMENTS, MOST IMPORTANT TO 1979 01:10:29,120 --> 01:10:29,400 NCI. 1980 01:10:29,400 --> 01:10:37,200 THAT IS IN TERMS OF ENSURING 1981 01:10:37,200 --> 01:10:37,480 EFFICIENCY. 1982 01:10:37,480 --> 01:10:39,600 NCAB DELEGATES TO THE DIRECTOR 1983 01:10:39,600 --> 01:10:41,440 OF THE NATIONAL CANCER INSTITUTE 1984 01:10:41,440 --> 01:10:43,520 PERMISSION TO ALLOW STAFF TO 1985 01:10:43,520 --> 01:10:44,920 NEGOTIATE APPROPRIATE 1986 01:10:44,920 --> 01:10:46,600 ADJUSTMENTS IN DOLLARS, OTHER 1987 01:10:46,600 --> 01:10:48,680 TERMS, AND CONDITIONS OF GRANT 1988 01:10:48,680 --> 01:10:52,440 AND CORPORATE AGREEMENT AWARDS 1989 01:10:52,440 --> 01:10:55,000 RECOMMENDED BY THE BOARD. 1990 01:10:55,000 --> 01:10:59,880 IN DOING SO, THIS MAINTAINS THE 1991 01:10:59,880 --> 01:11:01,080 EFFECTIVE AND SMOOTH OPERATION 1992 01:11:01,080 --> 01:11:04,800 OF GRANTS BY THE INSTITUTES. 1993 01:11:04,800 --> 01:11:08,840 STAFF WILL ALSO BE ABLE TO 1994 01:11:08,840 --> 01:11:11,200 NEGOTIATE APPROPRIATE ADJUSTMENT 1995 01:11:11,200 --> 01:11:11,920 WHEN APPLICABLE. 1996 01:11:11,920 --> 01:11:17,040 STAFF WILL ALSO MAKE ADJUSTMENTS 1997 01:11:17,040 --> 01:11:18,160 TO RECONCILE INCONSISTENCIES 1998 01:11:18,160 --> 01:11:22,080 BETWEEN RECOMMENDED BUDGET AND 1999 01:11:22,080 --> 01:11:28,040 RECOMMENDED AIMS AND ACTIVITIES. 2000 01:11:28,040 --> 01:11:33,600 REQUEST FOR INCREASE IN DIRECT 2001 01:11:33,600 --> 01:11:36,000 COSTS, SIGNIFICANT CHANGE IN 2002 01:11:36,000 --> 01:11:36,640 SCIENTIFIC CONTENT AFTER FORMAL 2003 01:11:36,640 --> 01:11:38,280 PEER REVIEW WILL BE REFERRED TO 2004 01:11:38,280 --> 01:11:46,440 THE BOARD FOR ADVICE AND 2005 01:11:46,440 --> 01:11:46,800 RECOMMENDATION. 2006 01:11:46,800 --> 01:11:50,240 ACTIONS SUCH AS CHANGE OF 2007 01:11:50,240 --> 01:11:52,120 INSTITUTION, CHANGE OF PRINCIPAL 2008 01:11:52,120 --> 01:11:53,840 INVESTIGATOR, PHASE OUT OF 2009 01:11:53,840 --> 01:11:55,400 INTERIM OR ADDITIONAL SUPPORT TO 2010 01:11:55,400 --> 01:11:58,120 MEET INCREASED COST OF 2011 01:11:58,120 --> 01:12:00,600 MAINTAINING LEVEL OF RESEARCH 2012 01:12:00,600 --> 01:12:02,000 PREVIOUSLY RECOMMENDED OR TO 2013 01:12:02,000 --> 01:12:03,800 ACCOMMODATE ACTIVITIES JUDGED BY 2014 01:12:03,800 --> 01:12:09,320 STAFF TO BE WITHIN THE SCOPE OF 2015 01:12:09,320 --> 01:12:10,080 THE PREVIOUSLY PEER REVIEWED 2016 01:12:10,080 --> 01:12:13,240 RESEARCH NEED NOT BE REPORTED TO 2017 01:12:13,240 --> 01:12:15,400 THE BOARD. 2018 01:12:15,400 --> 01:12:17,600 THE DIRECTOR IN ADDITION STAFF 2019 01:12:17,600 --> 01:12:21,440 MAY RESTORE REQUEST FOR TIME AND 2020 01:12:21,440 --> 01:12:23,120 SUPPORT WHICH WERE DELETED BY 2021 01:12:23,120 --> 01:12:25,960 THE INITIAL REVIEW GROUP WHEN 2022 01:12:25,960 --> 01:12:28,560 THE PRINCIPAL INVESTIGATOR HAS 2023 01:12:28,560 --> 01:12:31,520 PROVIDED JUSTIFICATION IN AN 2024 01:12:31,520 --> 01:12:33,480 APPEAL LETTER, THE RESTORATION 2025 01:12:33,480 --> 01:12:35,120 IS IN THE BEST INTEREST OF THE 2026 01:12:35,120 --> 01:12:40,600 NCI AND THE PROJECT IS OF HIGH 2027 01:12:40,600 --> 01:12:43,800 NCI PROGRAMMATIC RELEVANCE. 2028 01:12:43,800 --> 01:12:46,960 ADDITIONALLY, DIRECTOR OF NCI 2029 01:12:46,960 --> 01:12:50,240 AFTER CONSULTATION WITH NCAB 2030 01:12:50,240 --> 01:12:52,760 CHAIR MAY MAKE EXCEPTIONS TO 2031 01:12:52,760 --> 01:12:54,040 THESE GUIDELINES. 2032 01:12:54,040 --> 01:12:56,680 FINALLY, THERE IS THE SPECIAL 2033 01:12:56,680 --> 01:12:59,480 COUNCIL REVIEW OF PRINCIPAL 2034 01:12:59,480 --> 01:13:00,800 INVESTIGATORS WITH GREATER THAN 2035 01:13:00,800 --> 01:13:07,440 ONE MILLION DIRECT COST IN RPG 2036 01:13:07,440 --> 01:13:07,680 AWARDS. 2037 01:13:07,680 --> 01:13:10,080 AND NIH INSTITUTED THIS POLICY 2038 01:13:10,080 --> 01:13:13,520 IN AN EFFORT TO CONTINUE 2039 01:13:13,520 --> 01:13:16,680 RESPONSIBLE STEWARDSHIP OF 2040 01:13:16,680 --> 01:13:18,400 PUBLIC FUNDS AND SUPPORT 2041 01:13:18,400 --> 01:13:20,800 MERITORIOUS AND INNOVATEIVE 2042 01:13:20,800 --> 01:13:21,800 RESEARCH. 2043 01:13:21,800 --> 01:13:26,760 NOW, I SHOULD SAY THAT THIS ONE 2044 01:13:26,760 --> 01:13:33,800 MILLION DIRECT COST WILL NO 2045 01:13:33,800 --> 01:13:38,040 LONGER EXIST FOLLOWING THIS 2046 01:13:38,040 --> 01:13:38,280 MEETING. 2047 01:13:38,280 --> 01:13:41,920 BEGINNING IMMEDIATELY FOLLOWING 2048 01:13:41,920 --> 01:13:44,880 THIS MEETING, THE DOLLAR LEVEL 2049 01:13:44,880 --> 01:13:49,360 WILL BE TWO MILLION TOTAL COST, 2050 01:13:49,360 --> 01:13:54,440 THAT THE BOARD WILL CONSIDER IN 2051 01:13:54,440 --> 01:14:00,200 REVIEWING SPECIAL COUNCIL REVIEW 2052 01:14:00,200 --> 01:14:00,560 APPLICATIONS. 2053 01:14:00,560 --> 01:14:03,800 THIS IS A THRESHOLD ONLY TODAY 2054 01:14:03,800 --> 01:14:07,040 AND IT WILL BE A THRESHOLD GOING 2055 01:14:07,040 --> 01:14:07,920 FORWARD. 2056 01:14:07,920 --> 01:14:09,560 INVESTIGATORS WHO HAVE MORE 2057 01:14:09,560 --> 01:14:11,960 RESEARCH SUPPORT MAY STILL 2058 01:14:11,960 --> 01:14:14,680 RECEIVE ADDITIONAL AWARDS AS 2059 01:14:14,680 --> 01:14:15,200 WARRANTED. 2060 01:14:15,200 --> 01:14:16,560 THE REVISED CONSIDERATION AS 2061 01:14:16,560 --> 01:14:19,040 I'VE INDICATED WILL OCCUR WHEN 2062 01:14:19,040 --> 01:14:22,440 THE GRANTS ARE CONSIDERED AT THE 2063 01:14:22,440 --> 01:14:25,840 JUNE NCAB MEETING DURING CLOSED 2064 01:14:25,840 --> 01:14:26,120 SESSIONS. 2065 01:14:26,120 --> 01:14:29,800 BUT TODAY IT'S STILL ONE MILLION 2066 01:14:29,800 --> 01:14:31,600 DIRECT COST. 2067 01:14:31,600 --> 01:14:33,920 OKAY? 2068 01:14:33,920 --> 01:14:45,600 OKAY. 2069 01:14:45,600 --> 01:14:46,480 ARE THERE QUESTIONS? 2070 01:14:46,480 --> 01:14:48,840 IF NOT, JOHN WILL CALL FOR A 2071 01:14:48,840 --> 01:14:49,080 VOTE. 2072 01:14:49,080 --> 01:14:53,000 >> WE NEED TO CALL A VOTE TO 2073 01:14:53,000 --> 01:14:54,280 CONFIRM DELEGATIONS OF 2074 01:14:54,280 --> 01:14:54,560 AUTHORITY. 2075 01:14:54,560 --> 01:15:02,160 DO WE HAVE A MOTION? 2076 01:15:02,160 --> 01:15:06,360 >> SO MOVED. 2077 01:15:06,360 --> 01:15:11,040 >> SECOND? 2078 01:15:11,040 --> 01:15:13,800 >> SECOND. 2079 01:15:13,800 --> 01:15:14,160 >> DISCUSSION? 2080 01:15:14,160 --> 01:15:16,000 PLEASE VOTE YAY OR NAY. 2081 01:15:16,000 --> 01:15:16,520 NO ABSTENTIONS. 2082 01:15:16,520 --> 01:15:19,680 >> I SAW TWO HANDS GO UP. 2083 01:15:19,680 --> 01:15:24,200 >> SO LET ME SEE ALL NAYS. 2084 01:15:24,200 --> 01:15:24,720 YAYS. 2085 01:15:24,720 --> 01:15:25,600 YAYS. 2086 01:15:25,600 --> 01:15:26,160 YAYS. 2087 01:15:26,160 --> 01:15:28,680 ANY NAYS? 2088 01:15:28,680 --> 01:15:32,840 ANY NAYS? 2089 01:15:32,840 --> 01:15:37,800 ANYONE NEED TO ABSTAIN? 2090 01:15:37,800 --> 01:15:40,120 YAYS HAVE IT. 2091 01:15:40,120 --> 01:15:49,400 >> THANKS, JOHN. 2092 01:15:49,400 --> 01:15:51,720 >> THANK YOU, PAULETTE. 2093 01:15:51,720 --> 01:15:57,200 NEXT IS THE TRIENNIAL GENDER AND 2094 01:15:57,200 --> 01:15:58,160 MINORITY IN CLINICAL TRIALS 2095 01:15:58,160 --> 01:16:00,080 INCLUSION REPORT PROVIDED BY DR. 2096 01:16:00,080 --> 01:16:00,960 MARGARET MOONEY, ASSOCIATE 2097 01:16:00,960 --> 01:16:08,280 DIRECTOR OF THE CANCER TREATMENT 2098 01:16:08,280 --> 01:16:10,680 EVALUATION PROGRAM, CTEP. 2099 01:16:10,680 --> 01:16:11,160 MEG? 2100 01:16:11,160 --> 01:16:14,080 >> THANK YOU VERY MUCH. 2101 01:16:14,080 --> 01:16:23,760 I'M HAPPY TO PRESENT THE 2102 01:16:23,760 --> 01:16:26,880 TRIENNIAL RECORD FOR FISCAL 2103 01:16:26,880 --> 01:16:31,480 YEARS 2019-2020. 2104 01:16:31,480 --> 01:16:36,840 NEXT SLIDE PLEASE. 2105 01:16:36,840 --> 01:16:39,880 NIH IS MANDATED TO INCLUDE WOMEN 2106 01:16:39,880 --> 01:16:41,800 AND MINORITY GROUPS IN NIH 2107 01:16:41,800 --> 01:16:44,280 FUNDED RESEARCH, THE GOAL OF THE 2108 01:16:44,280 --> 01:16:47,360 LAW INSTITUTED IN THE 1970s IS 2109 01:16:47,360 --> 01:16:49,400 TO ENSURE RESEARCH FINDINGS CAN 2110 01:16:49,400 --> 01:16:51,280 BE MADE GENERALIZABLE TO THE 2111 01:16:51,280 --> 01:16:53,800 ENTIRE PATIENT POPULATION. 2112 01:16:53,800 --> 01:16:55,720 THE NIH REVITALIZATION ACT, 2113 01:16:55,720 --> 01:16:57,920 AMENDED BY THE 21ST CENTURY 2114 01:16:57,920 --> 01:16:59,960 CURES, ALSO REQUIRES ADVISORY 2115 01:16:59,960 --> 01:17:05,160 BOARD OF EACH NIH INSTITUTE TO 2116 01:17:05,160 --> 01:17:06,360 PREPARE TRIENNIAL REPORT 2117 01:17:06,360 --> 01:17:10,960 DESCRIBING THE MANNER THE NIH 2118 01:17:10,960 --> 01:17:12,680 COMPLIED FOR INCLUSION 2119 01:17:12,680 --> 01:17:13,120 REPORTING. 2120 01:17:13,120 --> 01:17:17,600 THE PRESENTATION TODAY WILL 2121 01:17:17,600 --> 01:17:20,800 EXPAND ON THE DATA SUBMITTED TO 2122 01:17:20,800 --> 01:17:23,560 THE NCAB. 2123 01:17:23,560 --> 01:17:25,880 NEXT SLIDE PLEASE. 2124 01:17:25,880 --> 01:17:29,200 THE SOURCE OF DATA INCLUDED 2125 01:17:29,200 --> 01:17:33,360 INCLUSION DATA IS QUITE BROAD. 2126 01:17:33,360 --> 01:17:34,840 IT INCLUDES CLINICAL RESEARCH 2127 01:17:34,840 --> 01:17:36,960 PATIENT ORIENTED, THIS MEANS AN 2128 01:17:36,960 --> 01:17:38,160 INVESTIGATOR DIRECTLY INTERACTS 2129 01:17:38,160 --> 01:17:41,080 WITH HUMAN SUBJECTS FOR THE 2130 01:17:41,080 --> 01:17:41,440 RESEARCH. 2131 01:17:41,440 --> 01:17:42,960 THIS INCLUDES LARGE EPIDEMIOLOGY 2132 01:17:42,960 --> 01:17:44,560 AND BEHAVIORAL STUDIES AS WELL 2133 01:17:44,560 --> 01:17:47,480 AS OUTCOMES RESEARCH AND HEALTH 2134 01:17:47,480 --> 01:17:48,320 SERVICES RESEARCH. 2135 01:17:48,320 --> 01:17:49,200 GRANTEES MUST REPORT INFORMATION 2136 01:17:49,200 --> 01:17:55,200 BE A WAIL -- ANNUALLY, AND ANY 2137 01:17:55,200 --> 01:17:56,960 CLINICAL RESEARCH SUPPORTED BY 2138 01:17:56,960 --> 01:17:58,840 GRANTS OR INTRAMURAL NCI PROGRAM 2139 01:17:58,840 --> 01:18:02,800 IS ALSO REPORTED ANNUALLY. 2140 01:18:02,800 --> 01:18:04,200 NEXT SLIDE. 2141 01:18:04,200 --> 01:18:07,800 WE'VE LISTED HERE ALL THE NCI 2142 01:18:07,800 --> 01:18:09,520 DIVISIONS, OFFICES, CENTERS, 2143 01:18:09,520 --> 01:18:11,400 WHICH REPORT ON CLINICAL 2144 01:18:11,400 --> 01:18:14,760 RESEARCH ON INCLUSION REPORTING 2145 01:18:14,760 --> 01:18:16,080 FOR THE NCI. 2146 01:18:16,080 --> 01:18:16,960 RESEARCH DIFFERS BY DIFFERENT 2147 01:18:16,960 --> 01:18:19,800 PROGRAMS BUT WE'RE ALL REQUIRED 2148 01:18:19,800 --> 01:18:23,840 TO REPORT. 2149 01:18:23,840 --> 01:18:24,520 NEXT SLIDE. 2150 01:18:24,520 --> 01:18:26,600 THERE ARE SEVERAL STRATEGIES FOR 2151 01:18:26,600 --> 01:18:27,960 ENSURING COMPLIANCE, FIRST 2152 01:18:27,960 --> 01:18:29,760 STARTS WITH PEER REVIEW, 2153 01:18:29,760 --> 01:18:32,120 REVIEWERS EVALUATE APPLICATIONS 2154 01:18:32,120 --> 01:18:33,800 FOR THE APPROPRIATENESS OF 2155 01:18:33,800 --> 01:18:34,800 CONCLUSION PLANS AND ANALYSES, 2156 01:18:34,800 --> 01:18:36,480 THAT'S FOLLOWED BY PROGRAM 2157 01:18:36,480 --> 01:18:38,200 MONITORING AND GRANTS MANAGEMENT 2158 01:18:38,200 --> 01:18:40,120 OVERSIGHT, ONCE AN AWARD IS 2159 01:18:40,120 --> 01:18:40,480 MADE. 2160 01:18:40,480 --> 01:18:42,880 ON THE INTRAMURAL SIDE, 2161 01:18:42,880 --> 01:18:44,080 INTRAMURAL INVESTIGATORS PROVIDE 2162 01:18:44,080 --> 01:18:45,600 INCLUSION PLANS DURING THEIR 2163 01:18:45,600 --> 01:18:47,200 SCIENTIFIC REVIEW. 2164 01:18:47,200 --> 01:18:49,000 AND ENROLLMENT PROGRESS, AS PART 2165 01:18:49,000 --> 01:18:50,960 OF ANNUAL SCIENTIFIC AND IRB 2166 01:18:50,960 --> 01:18:51,600 REVIEW. 2167 01:18:51,600 --> 01:18:53,400 LAST BUT NOT LEAST, TRAINING IS 2168 01:18:53,400 --> 01:18:56,560 PROVIDED ON A REGULAR BASIS FOR 2169 01:18:56,560 --> 01:19:00,600 ALL PROGRAM AND REVIEW STAFF. 2170 01:19:00,600 --> 01:19:01,480 NEXT SLIDE PLEASE. 2171 01:19:01,480 --> 01:19:03,560 SO BEFORE WE PRESENT SOME OF THE 2172 01:19:03,560 --> 01:19:04,920 DATA FROM THE TRIENNIAL REPORT, 2173 01:19:04,920 --> 01:19:07,040 WE DID WANT TO POINT OUT THERE 2174 01:19:07,040 --> 01:19:08,360 ARE SOME KEY LIMITATIONS TO THE 2175 01:19:08,360 --> 01:19:10,520 DATA THAT YOU WILL SEE. 2176 01:19:10,520 --> 01:19:14,400 FIRST OF ALL, YOU'LL SEE REPORTS 2177 01:19:14,400 --> 01:19:15,080 NUMBERING INCLUSION DATA 2178 01:19:15,080 --> 01:19:15,320 RECORDS. 2179 01:19:15,320 --> 01:19:18,200 WE DID WANT TO POINT OUT THESE 2180 01:19:18,200 --> 01:19:19,080 DO NOT REPRESENT A TOTAL COUNT 2181 01:19:19,080 --> 01:19:21,800 OF THE NUMBER OF STUDIES OR 2182 01:19:21,800 --> 01:19:23,000 TRIALS DONE BECAUSE MULTIPLE 2183 01:19:23,000 --> 01:19:24,840 RECORDS MAY BE SUBMITTED FOR 2184 01:19:24,840 --> 01:19:25,200 SINGLE TRIAL. 2185 01:19:25,200 --> 01:19:27,800 IT DOES GIVE YOU THE VOLUME OF 2186 01:19:27,800 --> 01:19:30,480 REPORTING DONE ACROSS THE 2187 01:19:30,480 --> 01:19:32,000 PROGRAM BY GRANTEES, 2188 01:19:32,000 --> 01:19:33,000 CONTRACTORS, INTRAMURAL PROGRAM, 2189 01:19:33,000 --> 01:19:34,960 BUT DOES NOT REPRESENT EXACT 2190 01:19:34,960 --> 01:19:36,040 NUMBER OF STUDIES. 2191 01:19:36,040 --> 01:19:37,240 SECONDLY IT'S IMPORTANT TO 2192 01:19:37,240 --> 01:19:40,040 REMEMBER THAT THE INCLUSION DATA 2193 01:19:40,040 --> 01:19:42,000 DO NOT REPRESENT THE ENROLLMENT 2194 01:19:42,000 --> 01:19:44,720 OR RECORDS FOR A PARTICULAR 2195 01:19:44,720 --> 01:19:45,800 YEAR. 2196 01:19:45,800 --> 01:19:48,120 INSTEAD, THE ENROLLMENT DATA IS 2197 01:19:48,120 --> 01:19:50,040 REALLY CUMULATIVE, FOR A 2198 01:19:50,040 --> 01:19:51,200 PARTICULAR CLINICAL RESEARCH 2199 01:19:51,200 --> 01:19:52,400 STUDY DURING THE PROJECT PERIOD 2200 01:19:52,400 --> 01:19:56,920 AS LONG AS IT WAS ACTIVE IN THAT 2201 01:19:56,920 --> 01:19:58,000 FISCAL YEAR. 2202 01:19:58,000 --> 01:19:59,320 THIRDLY, GRANTS THAT ARE 2203 01:19:59,320 --> 01:20:01,000 COMPETED IN A FISCAL YEAR ARE 2204 01:20:01,000 --> 01:20:03,280 NOT INCLUDED IN THE DATA FOR 2205 01:20:03,280 --> 01:20:04,360 THAT YEAR. 2206 01:20:04,360 --> 01:20:06,400 SO THIS IS OF PARTICULAR 2207 01:20:06,400 --> 01:20:07,120 IMPORTANCE THIS TRIENNIAL REPORT 2208 01:20:07,120 --> 01:20:10,160 BECAUSE TWO OF OUR LARGEST 2209 01:20:10,160 --> 01:20:11,400 NATIONAL CLINICAL TRIALS 2210 01:20:11,400 --> 01:20:13,160 NETWORKS IN THE EXTRAMURAL 2211 01:20:13,160 --> 01:20:21,440 COMMUNITY, NATIONAL CLINICAL 2212 01:20:21,440 --> 01:20:25,600 TRIALS NETWORK AND NCCOR WILL 2213 01:20:25,600 --> 01:20:29,600 RECOMPETE IN 2019, ENROLLMENT IN 2214 01:20:29,600 --> 01:20:30,200 FISCAL YEAR 2019 ON CLINICAL 2215 01:20:30,200 --> 01:20:32,280 TRIALS THAT SPECIAL REPORT AS 2216 01:20:32,280 --> 01:20:34,800 WELL AS CLINICAL RESEARCH IS 2217 01:20:34,800 --> 01:20:36,800 LOWER BECAUSE THOSE TWO LARGE 2218 01:20:36,800 --> 01:20:38,840 NETWORKS WERE RECOMPETED IN 2219 01:20:38,840 --> 01:20:41,600 FISCAL YEAR 2019 AND SO THEIR 2220 01:20:41,600 --> 01:20:43,440 ENROLLMENT DATA IS NOT INCLUDED. 2221 01:20:43,440 --> 01:20:46,080 THERE WAS A ONE-TIME DATA ERROR 2222 01:20:46,080 --> 01:20:48,680 IN FISCAL YEAR 2021. 2223 01:20:48,680 --> 01:20:50,920 THAT INCLUDED OVERREPORTING ON A 2224 01:20:50,920 --> 01:20:52,600 SINGLE VERY LARGE TRIAL. 2225 01:20:52,600 --> 01:20:54,280 THAT UNFORTUNATELY WAS FROZEN AT 2226 01:20:54,280 --> 01:20:57,440 THE NIH LEVEL AND LED TO 2227 01:20:57,440 --> 01:20:58,960 SIGNIFICANTLY HIGHER FY 2021 2228 01:20:58,960 --> 01:20:59,880 ENROLLMENT. 2229 01:20:59,880 --> 01:21:02,200 WE HAVE HOWEVER NOTED THAT IN 2230 01:21:02,200 --> 01:21:03,120 THE REPORT, TRIENNIAL REPORT 2231 01:21:03,120 --> 01:21:05,960 SUBMITTED TO THE BOARD. 2232 01:21:05,960 --> 01:21:08,680 WE ALSO USED CORRECTIVE DATA 2233 01:21:08,680 --> 01:21:11,800 THROUGHOUT THIS PRESENTATION. 2234 01:21:11,800 --> 01:21:14,160 NEXT SLIDE PLEASE. 2235 01:21:14,160 --> 01:21:15,880 SO SUMMARY OF INCLUSION RECORDS 2236 01:21:15,880 --> 01:21:17,760 AND ENROLLMENT FOR CLINICAL 2237 01:21:17,760 --> 01:21:20,480 RESEARCH STUDIES IS PRESENTED 2238 01:21:20,480 --> 01:21:20,680 HERE. 2239 01:21:20,680 --> 01:21:22,600 THE TOTAL ENROLLMENT RANGE FROM 2240 01:21:22,600 --> 01:21:32,560 OVER 3.2 MILLION TO 3. 2241 01:21:32,560 --> 01:21:34,800 7 MILLION, 84 TO 87% WHO 2242 01:21:34,800 --> 01:21:37,880 ENROLLED WERE FROM THE UNITED 2243 01:21:37,880 --> 01:21:38,120 STATES. 2244 01:21:38,120 --> 01:21:39,080 NEXT SLIDE PLEASE. 2245 01:21:39,080 --> 01:21:41,680 WHEN WE LOOK AT THE BREAKDOWN, 2246 01:21:41,680 --> 01:21:43,400 CLINICAL RESEARCH STUDIES BY SEX 2247 01:21:43,400 --> 01:21:46,920 AND GENDER, YOU'LL SEE THERE'S A 2248 01:21:46,920 --> 01:21:48,440 PREDOMINANT PERSONAL OF FEMALE 2249 01:21:48,440 --> 01:21:49,160 PARTICIPANTS ON THESE STUDIES, 2250 01:21:49,160 --> 01:21:50,920 IN EACH OF THE FISCAL YEARS. 2251 01:21:50,920 --> 01:21:53,600 THAT DOES REPRESENT THE LARGE 2252 01:21:53,600 --> 01:21:56,720 NUMBER OF STUDIES THAT DO IN 2253 01:21:56,720 --> 01:21:58,040 FEMALE MALIGNANCIES, 2254 01:21:58,040 --> 01:21:59,960 PARTICULARLY BREAST CANCER. 2255 01:21:59,960 --> 01:22:01,560 NEXT SLIDE PLEASE. 2256 01:22:01,560 --> 01:22:04,440 WHEN WE EXCLUDE ALL STUDIES IN 2257 01:22:04,440 --> 01:22:06,760 CLINICAL RESEARCH STUDIES THAT 2258 01:22:06,760 --> 01:22:08,400 ARE EXCLUSIVE JUST TO MEN OR 2259 01:22:08,400 --> 01:22:09,680 JUST TO WOMEN, YOU'LL SEE 2260 01:22:09,680 --> 01:22:12,200 THERE'S A MUCH MORE EVEN 2261 01:22:12,200 --> 01:22:13,000 BREAKDOWN BETWEEN THE PERCENTAGE 2262 01:22:13,000 --> 01:22:15,840 OF MEN AND WOMEN WHO ARE 2263 01:22:15,840 --> 01:22:17,800 PARTICIPANTS IN THE CLINICAL 2264 01:22:17,800 --> 01:22:20,560 RESEARCH STUDIES BY THE NCI AS 2265 01:22:20,560 --> 01:22:23,480 NOTED ON THIS SLIDE. 2266 01:22:23,480 --> 01:22:24,720 NEXT SLIDE PLEASE. 2267 01:22:24,720 --> 01:22:26,440 WHEN WE LOOK AT MINORITY 2268 01:22:26,440 --> 01:22:28,200 PARTICIPANTS BY RACE AND 2269 01:22:28,200 --> 01:22:32,680 ETHNICITY, WE LIKE TO POINT OUT 2270 01:22:32,680 --> 01:22:35,280 THAT THE NIH INCLUSION DATA 2271 01:22:35,280 --> 01:22:36,520 MINORITY PARTICIPANTS ARE 2272 01:22:36,520 --> 01:22:38,800 DEFINED AS PARTICIPANTS THAT 2273 01:22:38,800 --> 01:22:43,840 HAVE A NON-WHITE RACE, AND OR 2274 01:22:43,840 --> 01:22:44,960 ARE PARTICIPATES WHO ARE 2275 01:22:44,960 --> 01:22:46,280 HISPANIC OR LATINO. 2276 01:22:46,280 --> 01:22:47,760 YOU CAN SEE OVER THREE FISCAL 2277 01:22:47,760 --> 01:22:49,840 YEAR THERE WAS A STABLE 2278 01:22:49,840 --> 01:22:51,800 PERCENTAGE OF MINORITY 2279 01:22:51,800 --> 01:22:56,600 PARTICIPATION USING THAT 2280 01:22:56,600 --> 01:22:58,120 DEFINITION OF ABOUT 22%. 2281 01:22:58,120 --> 01:23:00,920 WHEN WE BREAK DOWN ETHNICITY, 2282 01:23:00,920 --> 01:23:02,960 FOR ALL CLINICAL RESEARCH 2283 01:23:02,960 --> 01:23:05,400 STUDIES, YOU'LL SEE THE 2284 01:23:05,400 --> 01:23:07,840 PERCENTAGE OF HISPANIC AND 2285 01:23:07,840 --> 01:23:10,480 LATINO PATIENTS HAS REMAINED 2286 01:23:10,480 --> 01:23:12,120 FAIRLY STABLE FROM ABOUT 9% OVER 2287 01:23:12,120 --> 01:23:13,880 THE COURSE OF EACH OF THE THREE 2288 01:23:13,880 --> 01:23:14,640 FISCAL YEARS. 2289 01:23:14,640 --> 01:23:19,440 THERE'S A LARGE NUMBER OF 2290 01:23:19,440 --> 01:23:20,320 UNREPORTED IS ETHNICITY, 2291 01:23:20,320 --> 01:23:24,680 SOMETIMES THAT REPRESENTS LARGE 2292 01:23:24,680 --> 01:23:25,560 OBSERVATIONAL STUDIES WHERE 2293 01:23:25,560 --> 01:23:34,680 THERE WERE HIGH NUMBERS OF 2294 01:23:34,680 --> 01:23:35,600 UNKNOWN OR NON-REPORTED 2295 01:23:35,600 --> 01:23:36,080 PARTICIPANTS. 2296 01:23:36,080 --> 01:23:38,360 BY RACE, YOU CAN SEE PERCENTAGE 2297 01:23:38,360 --> 01:23:40,080 BREAK DOWN FOR EACH OF THE 2298 01:23:40,080 --> 01:23:46,880 FISCAL YEARS, AS YOU CAN SEE THE 2299 01:23:46,880 --> 01:23:48,960 WHITE PARTICIPATION RANGED IN 2300 01:23:48,960 --> 01:23:53,040 60% RANGE, FAIRLY STABLE RATES 2301 01:23:53,040 --> 01:23:53,640 OF DIFFERENT MINORITY 2302 01:23:53,640 --> 01:23:55,880 REPRESENTATION ACROSS EACH OF 2303 01:23:55,880 --> 01:24:00,720 THE THREE FISCAL YEARS. 2304 01:24:00,720 --> 01:24:01,600 NEXT SLIDE PLEASE. 2305 01:24:01,600 --> 01:24:04,120 WE DO NOT HAVE TO REPORT BY THE 2306 01:24:04,120 --> 01:24:06,360 TRIENNIAL REPORT TO NIH, 2307 01:24:06,360 --> 01:24:08,280 BREAKDOWN BETWEEN EXTRAMURAL AND 2308 01:24:08,280 --> 01:24:12,200 INTRAMURAL STUDIES AT THE NCI. 2309 01:24:12,200 --> 01:24:15,600 WE DID PROVIDE THIS TO SHARE THE 2310 01:24:15,600 --> 01:24:17,960 BREAKDOWN WITH YOU. 2311 01:24:17,960 --> 01:24:18,880 IT SHOWS ROBUST ENROLLMENT OF 2312 01:24:18,880 --> 01:24:20,440 MILLIONS OF PATIENTS IN THE 2313 01:24:20,440 --> 01:24:22,280 EXTRAMURAL PROGRAMS AS WELL AS 2314 01:24:22,280 --> 01:24:23,600 INTRAMURAL PROGRAMS. 2315 01:24:23,600 --> 01:24:24,720 THERE ARE SOME SLIGHT 2316 01:24:24,720 --> 01:24:27,360 DIFFERENCES IN TERMS OF THE 2317 01:24:27,360 --> 01:24:28,320 NUMBER OR BREAKDOWN, EXCUSE ME, 2318 01:24:28,320 --> 01:24:31,720 IN GENDER FOR PATIENTS AS WELL 2319 01:24:31,720 --> 01:24:34,200 AS ETHNICITY AND RACE DEPENDING 2320 01:24:34,200 --> 01:24:38,320 ON THE TYPES OF CLINICAL TRIALS 2321 01:24:38,320 --> 01:24:41,560 DONE IN THE EXTRAMURAL AS 2322 01:24:41,560 --> 01:24:44,720 OPPOSED TO INTRAMURALLY AT NCI. 2323 01:24:44,720 --> 01:24:45,720 NEXT SLIDE PLEASE. 2324 01:24:45,720 --> 01:24:48,120 THERE ARE SPECIAL CONSIDERATIONS 2325 01:24:48,120 --> 01:24:51,840 GIVEN FOR NIH-DEFINED PHASE 3 2326 01:24:51,840 --> 01:24:56,920 TRIALS, WE PROVIDED DEFINITION 2327 01:24:56,920 --> 01:24:59,120 FOR TRIALS THAT NIH IS IN THE 2328 01:24:59,120 --> 01:25:01,520 MIDDLE OF THE SLIDE, DIFFICULT 2329 01:25:01,520 --> 01:25:03,800 TO READ, BUT WE DO CLEARLY 2330 01:25:03,800 --> 01:25:05,640 DEFINE ALL PHASE 3 CLINICAL 2331 01:25:05,640 --> 01:25:07,400 TRIALS DONE AT NCI BECAUSE WE'RE 2332 01:25:07,400 --> 01:25:09,200 REQUIRED TO HAVE DESIGNS THAT 2333 01:25:09,200 --> 01:25:13,760 PERMIT A VALID ANALYSIS ON THE 2334 01:25:13,760 --> 01:25:15,760 BASIS OF SEX, RACE, ETHNICITY. 2335 01:25:15,760 --> 01:25:19,480 AS SUCH WE PERFORM ADDITIONAL 2336 01:25:19,480 --> 01:25:20,400 REQUIREMENTS FOR NIH-DEFINED 2337 01:25:20,400 --> 01:25:22,400 PHASE 3 TRIALS, SO THAT WE 2338 01:25:22,400 --> 01:25:25,280 REPORT THOSE SEPARATELY AS PART 2339 01:25:25,280 --> 01:25:26,600 OF THE TRIENNIAL INCLUSION 2340 01:25:26,600 --> 01:25:26,840 REPORT. 2341 01:25:26,840 --> 01:25:28,640 AND I'LL BE DOING THAT ON THE 2342 01:25:28,640 --> 01:25:31,960 NEXT FEW SLIDES. 2343 01:25:31,960 --> 01:25:33,240 NEXT SLIDE. 2344 01:25:33,240 --> 01:25:35,360 HERE'S JUST A SUMMARY OF 2345 01:25:35,360 --> 01:25:37,320 INCLUSION RECORDS OF ENROLLMENT 2346 01:25:37,320 --> 01:25:38,040 NUMBERS FOR ALL PHASE 3 CLINICAL 2347 01:25:38,040 --> 01:25:40,160 TRIALS DONE AT THE NCI. 2348 01:25:40,160 --> 01:25:44,320 AS I POINTED OUT EARLIER, FISCAL 2349 01:25:44,320 --> 01:25:47,400 YEAR 2019, TWO LARGEST NATIONAL 2350 01:25:47,400 --> 01:25:49,200 PROGRAM ALSO, NCCOR AND NCTN 2351 01:25:49,200 --> 01:25:50,560 WHICH DO PHASE 3 CLINICAL 2352 01:25:50,560 --> 01:25:52,760 TRIALS, THEIR ENROLLMENT NUMBERS 2353 01:25:52,760 --> 01:25:55,320 WERE NOT INCLUDED BECAUSE THEY 2354 01:25:55,320 --> 01:25:56,600 ARE UNDERWENT RECOMPETITION THAT 2355 01:25:56,600 --> 01:25:59,200 YEAR BUT YOU CAN SEE IN 2020 AND 2356 01:25:59,200 --> 01:26:02,320 2021 A MORE THAN DOUBLING OF 2357 01:26:02,320 --> 01:26:04,960 TOTAL ENROLLMENT REFLECTING THE 2358 01:26:04,960 --> 01:26:05,600 CONTRIBUTION OF PARTICIPANTS IN 2359 01:26:05,600 --> 01:26:06,800 PHASE 3 CLINICAL TRIALS FROM 2360 01:26:06,800 --> 01:26:09,960 THOSE TWO NETWORKS. 2361 01:26:09,960 --> 01:26:12,800 IF YOU LOOK OVERALL IN ALL THREE 2362 01:26:12,800 --> 01:26:14,600 FISCAL YEARS PERCENT OF U.S. 2363 01:26:14,600 --> 01:26:19,080 ONLY RANGES FROM 74% TO 78%. 2364 01:26:19,080 --> 01:26:19,840 NEXT SLIDE PLEASE. 2365 01:26:19,840 --> 01:26:23,880 IF WE LOOK AT THE BREAKDOWN FOR 2366 01:26:23,880 --> 01:26:27,560 PHASE 3 TRIALS BY SEX AND GENDER 2367 01:26:27,560 --> 01:26:28,200 THERE'S PREDOMINANT PERCENTAGE 2368 01:26:28,200 --> 01:26:29,160 WHO ARE FEMALE. 2369 01:26:29,160 --> 01:26:33,200 YOU CAN SEE THAT WAS 60% IN FY 2370 01:26:33,200 --> 01:26:34,080 2019. 2371 01:26:34,080 --> 01:26:36,160 HOWEVER, FY 2020 AND FY 2021 2372 01:26:36,160 --> 01:26:38,000 THERE'S A SIGNIFICANT INCREASE 2373 01:26:38,000 --> 01:26:39,760 IN THE NUMBER OF PARTICIPANTS 2374 01:26:39,760 --> 01:26:41,160 WHO WERE FEMALE. 2375 01:26:41,160 --> 01:26:43,840 THIS HIGHER PROPORTION OF FEMALE 2376 01:26:43,840 --> 01:26:45,000 PARTICIPANTS REPORTED IN THOSE 2377 01:26:45,000 --> 01:26:48,400 TWO YEARS WAS LARGELY DRIVEN BY 2378 01:26:48,400 --> 01:26:50,880 SIGNIFICANT ENROLLMENT TO LARGE 2379 01:26:50,880 --> 01:26:53,600 NCCOR PREVENTION OR SCREENING 2380 01:26:53,600 --> 01:26:55,760 TRIAL, EXCUSE ME, IN EVALUATING 2381 01:26:55,760 --> 01:26:57,200 TWO DIFFERENT TYPES OF 2382 01:26:57,200 --> 01:26:58,720 MAMMOGRAPHY IN WOMEN WHO WERE 2383 01:26:58,720 --> 01:27:01,960 BEING SCREENED FOR BREAST 2384 01:27:01,960 --> 01:27:02,360 CANCER. 2385 01:27:02,360 --> 01:27:04,160 NEXT SLIDE. 2386 01:27:04,160 --> 01:27:06,480 IF WE WERE TO REMOVE ALL STUDIES 2387 01:27:06,480 --> 01:27:09,360 OR PHASE 3 TRIALS, EXCUSE ME, IN 2388 01:27:09,360 --> 01:27:10,320 WHICH THEY WERE DEVOTED, YOU HAD 2389 01:27:10,320 --> 01:27:12,600 TO BE JUST MALE OR JUST FEMALE, 2390 01:27:12,600 --> 01:27:13,720 TO BE ENROLLED. 2391 01:27:13,720 --> 01:27:19,480 YOU CAN SEE THAT THE PERCENTAGE 2392 01:27:19,480 --> 01:27:22,120 AND BREAKDOWN IS MORE EVENLY 2393 01:27:22,120 --> 01:27:22,360 DIVIDED. 2394 01:27:22,360 --> 01:27:24,320 EVEN THE INCREASE THAT YOU SEE 2395 01:27:24,320 --> 01:27:26,360 HERE IN FISCAL YEAR 2020 AND 2396 01:27:26,360 --> 01:27:28,800 2021 WHERE THERE'S A LARGER 2397 01:27:28,800 --> 01:27:30,880 PERCENTAGE OF FEMALE PATIENTS, 2398 01:27:30,880 --> 01:27:35,240 PARTICIPANTS, EXCUSE ME, 2399 01:27:35,240 --> 01:27:36,880 REPRESENTS THAT LARGE BREAST 2400 01:27:36,880 --> 01:27:41,240 CANCERS ENROLL MALES, THERE ARE 2401 01:27:41,240 --> 01:27:42,160 VERY FEW MALE PARTICIPANTS ON 2402 01:27:42,160 --> 01:27:44,200 THOSE TRIALS. 2403 01:27:44,200 --> 01:27:46,280 IF YOU EXCLUDED THOSE, THE 2404 01:27:46,280 --> 01:27:48,040 BREAKDOWN IS VERY EVEN BETWEEN 2405 01:27:48,040 --> 01:27:51,960 MEN AND WOMEN FOR OUR PHASE 3 2406 01:27:51,960 --> 01:27:54,320 CLINICAL TRIALS. 2407 01:27:54,320 --> 01:27:55,840 NEXT SLIDE PLEASE. 2408 01:27:55,840 --> 01:27:58,080 THIS SHOWS INCLUSION DATA FOR 2409 01:27:58,080 --> 01:28:00,440 ALL PHASE 3 CLINICAL TRIALS FOR 2410 01:28:00,440 --> 01:28:01,320 PROPORTION OF MINORITY 2411 01:28:01,320 --> 01:28:03,600 PARTICIPANTS BY RACE AND 2412 01:28:03,600 --> 01:28:05,120 ETHNICITY. 2413 01:28:05,120 --> 01:28:07,560 AGAIN, THAT'S ANYONE WHO 2414 01:28:07,560 --> 01:28:10,680 PARTICIPATES WITH A NON-WHITE OR 2415 01:28:10,680 --> 01:28:14,000 HISPANIC OR LATINO, AND THIS IS 2416 01:28:14,000 --> 01:28:17,320 FAIRLY STABLE OVER ALL OF THE 2417 01:28:17,320 --> 01:28:21,800 FISCAL YEARS AROUND THE MID-40% 2418 01:28:21,800 --> 01:28:22,160 RANGE. 2419 01:28:22,160 --> 01:28:23,440 NEXT SLIDE PLEASE. 2420 01:28:23,440 --> 01:28:25,840 HERE WE HAVE BREAKDOWN BY 2421 01:28:25,840 --> 01:28:26,120 ETHNICITY. 2422 01:28:26,120 --> 01:28:29,320 YOU CAN SEE THAT THE PERCENTAGE 2423 01:28:29,320 --> 01:28:32,600 OF HISPANIC AND LATINO PATIENTS, 2424 01:28:32,600 --> 01:28:35,280 PARTICIPANTS, HAS INCREASED FROM 2425 01:28:35,280 --> 01:28:38,080 FISCAL YEAR 2019 UP TO FISCAL 2426 01:28:38,080 --> 01:28:39,040 2021. 2427 01:28:39,040 --> 01:28:40,800 WE DID NOTE THAT PARTICULARLY 2428 01:28:40,800 --> 01:28:43,680 THE LARGE INCREASES IN HISPANIC 2429 01:28:43,680 --> 01:28:48,920 OR BUMP IN HISPANIC LATINO 2430 01:28:48,920 --> 01:28:52,200 PERCENTAGE IN 2020 AND 2021 ALSO 2431 01:28:52,200 --> 01:28:54,840 RELATES TO A VERY HEAVY AND 2432 01:28:54,840 --> 01:28:56,800 STRONG PARTICIPATION BY HISPANIC 2433 01:28:56,800 --> 01:29:01,480 AND LATINO PATIENTS BOTH U.S. 2434 01:29:01,480 --> 01:29:06,280 AND EX- EX-U.S. FOR THE TMIST 2435 01:29:06,280 --> 01:29:09,440 TRIAL THAT THE NCCOR WAS 2436 01:29:09,440 --> 01:29:15,920 RUNNING, EVALUATING TWO TYPES OF 2437 01:29:15,920 --> 01:29:17,880 MAMMOGRAPHY FOR WOMEN SCREENED 2438 01:29:17,880 --> 01:29:18,920 FOR BREAST CANCER. 2439 01:29:18,920 --> 01:29:20,320 THIS IS BY RACE. 2440 01:29:20,320 --> 01:29:22,280 THERE ARE SOME PARTICULAR ISSUES 2441 01:29:22,280 --> 01:29:24,360 IN THIS TRIENNIAL REPORT DUE TO 2442 01:29:24,360 --> 01:29:30,240 THE DATA IN THE PARTICULAR 2443 01:29:30,240 --> 01:29:32,320 STUDIES, IN FY 2019 EXCLUDES TWO 2444 01:29:32,320 --> 01:29:34,280 LARGE NATIONAL CLINICAL TRIALS 2445 01:29:34,280 --> 01:29:36,240 NETWORKS SUPPORTED IN THE 2446 01:29:36,240 --> 01:29:38,200 EXTRAMURAL COMMUNITY, THERE WAS 2447 01:29:38,200 --> 01:29:39,640 A LARGE PERCENTAGE OF BLACK AND 2448 01:29:39,640 --> 01:29:42,000 AFRICAN AMERICAN AS WELL AS 2449 01:29:42,000 --> 01:29:43,240 ASIAN PATIENTS, DUE TO 2450 01:29:43,240 --> 01:29:45,960 PARTICULAR TRIALS THAT WERE 2451 01:29:45,960 --> 01:29:47,560 FOCUSED ON THOSE PARTICULAR -- 2452 01:29:47,560 --> 01:29:50,280 THAT THOSE PARTICULAR TYPES OF 2453 01:29:50,280 --> 01:29:50,600 PARTICIPANTS. 2454 01:29:50,600 --> 01:29:53,800 WHEN WE WENT IN TO FISCAL YEAR 2455 01:29:53,800 --> 01:29:56,440 2020 AND 2021, ADDED THAT, THE 2456 01:29:56,440 --> 01:29:58,320 LARGE NATIONAL CLINICAL TRIALS 2457 01:29:58,320 --> 01:30:00,400 NETWORK ALSO, THE NCTN AND 2458 01:30:00,400 --> 01:30:05,200 NCCOR, YOU CAN SEE THERE WAS A 2459 01:30:05,200 --> 01:30:07,720 DROP IN BOTH ASIAN 2460 01:30:07,720 --> 01:30:09,640 PARTICIPATION, OVER INTO FISCAL 2461 01:30:09,640 --> 01:30:10,360 YEAR 2021. 2462 01:30:10,360 --> 01:30:13,840 AS WELL AS A DROP IN THE NUMBER 2463 01:30:13,840 --> 01:30:15,760 OR PERCENTAGE OVERALL OF BLACK 2464 01:30:15,760 --> 01:30:17,600 AND AFRICAN AMERICAN PATIENTS. 2465 01:30:17,600 --> 01:30:21,840 THERE WAS ALSO A ONE-TIME ERROR 2466 01:30:21,840 --> 01:30:24,200 IN TERMS OF CATEGORY OF MORE 2467 01:30:24,200 --> 01:30:26,880 THAN ONE RACE, AS OUR TRIALS 2468 01:30:26,880 --> 01:30:27,600 HAVE BECOME MORE COMPLEX ACROSS 2469 01:30:27,600 --> 01:30:30,680 THE BOARD BOTH EARLY PHASE AND 2470 01:30:30,680 --> 01:30:32,640 LATE PHASE CLINICAL TRIALS THERE 2471 01:30:32,640 --> 01:30:34,520 WAS COMPLEXITIES IN TERMS OF THE 2472 01:30:34,520 --> 01:30:36,280 NUMBER OF DIFFERENT STEPS A 2473 01:30:36,280 --> 01:30:39,400 PATIENT COULD GO ON TO IN 2474 01:30:39,400 --> 01:30:40,680 PARTICULAR CLINICAL TRIALS 2475 01:30:40,680 --> 01:30:41,760 PARTICULARLY LARGE CANCER 2476 01:30:41,760 --> 01:30:42,600 TREATMENT TRIALS THAT 2477 01:30:42,600 --> 01:30:44,680 UNFORTUNATELY LED TO AN ERROR IN 2478 01:30:44,680 --> 01:30:46,360 REPORTING OF MORE THAN ONE RACE. 2479 01:30:46,360 --> 01:30:48,320 THAT ERROR HAS BEEN CORRECTED. 2480 01:30:48,320 --> 01:30:52,000 YOU COULD NOT CORRECT FOR THE 2481 01:30:52,000 --> 01:30:53,400 PRESENTATION BUT GOING FORWARD 2482 01:30:53,400 --> 01:30:55,200 IN THE TRIENNIAL REPORTS THAT 2483 01:30:55,200 --> 01:30:56,000 WILL BE CORRECTED. 2484 01:30:56,000 --> 01:30:59,960 AS BEST AS WE CAN DETERMINE, 2485 01:30:59,960 --> 01:31:00,800 THAT ERROR SIMPLY MEANT PROBABLY 2486 01:31:00,800 --> 01:31:02,600 PERCENTAGE OF MORE THAN ONE RACE 2487 01:31:02,600 --> 01:31:05,960 IN FISCAL YEAR 2020 AND 2021 2488 01:31:05,960 --> 01:31:09,680 PROBABLY RESEMBLES MORE WHAT WAS 2489 01:31:09,680 --> 01:31:11,880 IN FISCAL YEAR 2019 AND EARLY 2490 01:31:11,880 --> 01:31:13,840 TRIENNIAL REPORTS, AND WOULD BE 2491 01:31:13,840 --> 01:31:16,120 EVENLY DISTRIBUTED ACROSS THE 2492 01:31:16,120 --> 01:31:18,880 OTHER PERCENTAGES IF IT HAD BEEN 2493 01:31:18,880 --> 01:31:21,320 APPROPRIATELY REPORTED. 2494 01:31:21,320 --> 01:31:22,400 NEXT SLIDE PLEASE. 2495 01:31:22,400 --> 01:31:24,240 SO THAT IS THE END OF OUR 2496 01:31:24,240 --> 01:31:24,600 PRESENTATION. 2497 01:31:24,600 --> 01:31:26,200 WE REALLY WOULD LIKE TO THANK 2498 01:31:26,200 --> 01:31:30,600 ALL THE NCI STAFF AND ALL THE 2499 01:31:30,600 --> 01:31:32,440 SUPPORTING INVESTIGATORS WHO 2500 01:31:32,440 --> 01:31:35,600 WORKED TO TRY TO INCLUDE AND 2501 01:31:35,600 --> 01:31:37,560 RECRUIT AS DIVERSE A PATIENT AND 2502 01:31:37,560 --> 01:31:39,800 PARTICIPANT POPULATION AS THEY 2503 01:31:39,800 --> 01:31:41,080 CAN TO ALL THE CLINICAL RESEARCH 2504 01:31:41,080 --> 01:31:46,800 DONE AT NCI AND WORKED TO 2505 01:31:46,800 --> 01:31:47,880 ENSURE ACCURACY OF DATA. 2506 01:31:47,880 --> 01:31:49,280 WE WOULD BE HAPPY TO ANSWER 2507 01:31:49,280 --> 01:31:49,960 QUESTIONS. 2508 01:31:49,960 --> 01:31:52,320 THANK YOU SO MUCH. 2509 01:31:52,320 --> 01:31:53,320 >> THANKS, MEG. 2510 01:31:53,320 --> 01:31:57,600 WE ONLY ENVIRONMENTAL A COUPLE 2511 01:31:57,600 --> 01:31:57,840 MINUTES. 2512 01:31:57,840 --> 01:32:00,840 PROBABLY ONLY HAVE TIME FOR ONE 2513 01:32:00,840 --> 01:32:02,440 OR TWO QUESTIONS. 2514 01:32:02,440 --> 01:32:05,560 I'LL YIELD TO ELECTRA AND I SEE 2515 01:32:05,560 --> 01:32:06,640 HOWARD'S HAND UP. 2516 01:32:06,640 --> 01:32:08,160 ELECTRA FIRST. 2517 01:32:08,160 --> 01:32:13,840 >> I JUST WANT TO MAKE TWO 2518 01:32:13,840 --> 01:32:14,960 SUGGESTIONS, AND OFFLINE I'M 2519 01:32:14,960 --> 01:32:16,240 HAPPY TO CHAT WITH YOU ABOUT 2520 01:32:16,240 --> 01:32:20,600 THIS, I EXPLORED THIS IN GREAT 2521 01:32:20,600 --> 01:32:21,520 DETAIL. 2522 01:32:21,520 --> 01:32:24,480 FIRST IS UNKNOWNS, THAT'S TOO 2523 01:32:24,480 --> 01:32:24,680 HIGH. 2524 01:32:24,680 --> 01:32:24,960 TOO HIGH. 2525 01:32:24,960 --> 01:32:26,960 I'D LIKE TO TALK TO YOU ABOUT 2526 01:32:26,960 --> 01:32:28,800 WHAT WE'RE SEEING THAT CAUSES 2527 01:32:28,800 --> 01:32:30,920 THAT THAT SO WE CAN TALK OFFLINE 2528 01:32:30,920 --> 01:32:31,680 ABOUT THAT. 2529 01:32:31,680 --> 01:32:33,880 THE SECOND THING, IT WOULD BE 2530 01:32:33,880 --> 01:32:35,960 VERY HELPFUL TO CONSIDER WHEN 2531 01:32:35,960 --> 01:32:38,280 YOU'RE DOING THESE PRESENTATIONS 2532 01:32:38,280 --> 01:32:41,400 TO HELP US ASSESS HOW THAT IS 2533 01:32:41,400 --> 01:32:41,880 REPRESENTATIVE OF THE 2534 01:32:41,880 --> 01:32:42,920 DEMOGRAPHICS IN THE UNITED 2535 01:32:42,920 --> 01:32:43,160 STATES. 2536 01:32:43,160 --> 01:32:44,600 YOU MIGHT WANT TO CONSIDER WHAT 2537 01:32:44,600 --> 01:32:46,640 WE IN THE CANCER CENTER WORLD 2538 01:32:46,640 --> 01:32:50,520 HAVE TO DO. 2539 01:32:50,520 --> 01:32:51,000 >> OKAY. 2540 01:32:51,000 --> 01:32:51,680 >> CLINICAL TRIAL DEMOGRAPHICS, 2541 01:32:51,680 --> 01:32:54,360 AT LEAST SHOW US THE PROPORTION 2542 01:32:54,360 --> 01:32:58,240 OF PEOPLE IN THE U.S. BY EACH OF 2543 01:32:58,240 --> 01:32:59,640 THOSE GENDER AND RACIAL GROUPS 2544 01:32:59,640 --> 01:33:02,200 TO GIVE US SOME SORT OF 2545 01:33:02,200 --> 01:33:02,600 MEASURING STICK. 2546 01:33:02,600 --> 01:33:04,280 AGAIN, I'M HAPPY TO CHAT WITH 2547 01:33:04,280 --> 01:33:05,560 YOU OFFLINE ABOUT THAT. 2548 01:33:05,560 --> 01:33:08,040 THANK YOU, THANK YOU VERY MUCH. 2549 01:33:08,040 --> 01:33:11,440 AND CONGRATULATIONS TO EVERYBODY 2550 01:33:11,440 --> 01:33:12,760 FOR SUPERB ACCRUAL, DIVERSE 2551 01:33:12,760 --> 01:33:14,080 ACCRUAL. 2552 01:33:14,080 --> 01:33:15,760 THANK YOU. 2553 01:33:15,760 --> 01:33:17,120 >> THANKS, ELECTRA. 2554 01:33:17,120 --> 01:33:17,360 HOWARD? 2555 01:33:17,360 --> 01:33:19,240 >> SURE. 2556 01:33:19,240 --> 01:33:22,280 MY QUESTIONS ARE LIKE ELECTRA'S 2557 01:33:22,280 --> 01:33:22,720 ACTUALLY. 2558 01:33:22,720 --> 01:33:23,760 FIRST POINT OF CLARIFICATION, 2559 01:33:23,760 --> 01:33:25,240 WHEN YOU'RE TALKING ABOUT THIS 2560 01:33:25,240 --> 01:33:27,880 GREAT DATA YOU'RE SHOWING US FOR 2561 01:33:27,880 --> 01:33:35,080 INCLUSION, DOES IT ACTUALLY ALSO 2562 01:33:35,080 --> 01:33:35,600 SHOW THE COMPLETERS, WHERE 2563 01:33:35,600 --> 01:33:40,640 ANNUAL SILLS CAN -- ANALYSIS CAN 2564 01:33:40,640 --> 01:33:43,000 BE DONE ABOUT CHOSEN PRIMARY 2565 01:33:43,000 --> 01:33:44,200 ENDPOINT AGAINST THE DEMOGRAPHIC 2566 01:33:44,200 --> 01:33:45,800 OR JUST WHO GETS INITIALLY 2567 01:33:45,800 --> 01:33:48,600 ENROLLED ON DAY ONE OF THE START 2568 01:33:48,600 --> 01:33:51,760 OF THE TRIAL IS WHAT YOU'RE 2569 01:33:51,760 --> 01:33:52,600 SHOWING US? 2570 01:33:52,600 --> 01:33:55,200 >> THIS IS PRIMARILY -- YES, 2571 01:33:55,200 --> 01:33:57,040 YOU'RE RIGHT, ENROLLMENT. 2572 01:33:57,040 --> 01:33:58,600 SOMETIMES ENROLLMENT IS ASSESSED 2573 01:33:58,600 --> 01:34:02,320 BY THE INDIVIDUAL PROGRAMS AND 2574 01:34:02,320 --> 01:34:04,160 INDIVIDUAL TRIAL, AFTER 2575 01:34:04,160 --> 01:34:06,680 WITHDRAWALS FOR OTHER REASONS 2576 01:34:06,680 --> 01:34:09,200 BUT I'M NOT -- ARE YOU ASKING 2577 01:34:09,200 --> 01:34:11,240 WHETHER IT'S ENROLLMENT AFTER 2578 01:34:11,240 --> 01:34:13,400 PATIENTS MAY HAVE WITHDRAWN 2579 01:34:13,400 --> 01:34:16,400 CONSENT OR SOME OTHER REASON 2580 01:34:16,400 --> 01:34:18,400 THEY DIDN'T GET OR CONTRIBUTE TO 2581 01:34:18,400 --> 01:34:19,200 THE PRIMARY ENDPOINT? 2582 01:34:19,200 --> 01:34:22,120 THERE CAN BE MANY REASONS. 2583 01:34:22,120 --> 01:34:24,920 THEY COME OFF, TOXICITY, I'M NOT 2584 01:34:24,920 --> 01:34:26,280 SURE I'M UNDERSTANDING YOUR 2585 01:34:26,280 --> 01:34:26,600 QUESTIONS. 2586 01:34:26,600 --> 01:34:28,160 >> WELL, DO YOU THINK IT WOULD 2587 01:34:28,160 --> 01:34:30,200 BE A COMPLEMENT TO THE KIND OF 2588 01:34:30,200 --> 01:34:33,000 DATA YOU'RE COLLECTING TO ALSO 2589 01:34:33,000 --> 01:34:34,960 SHOW COMPLETERS, AND HOW MANY OF 2590 01:34:34,960 --> 01:34:36,200 THE COMPLETERS THAT COMPLETE THE 2591 01:34:36,200 --> 01:34:39,320 END OF THE TRIAL AS DEFINED BY 2592 01:34:39,320 --> 01:34:41,960 THE PROTOCOL, AND HOW MANY OF 2593 01:34:41,960 --> 01:34:44,280 THOSE ARE IN DIFFERENT MINORITY 2594 01:34:44,280 --> 01:34:44,520 GROUPS. 2595 01:34:44,520 --> 01:34:46,920 I THINK IT WOULD BE. 2596 01:34:46,920 --> 01:34:48,960 >> OKAY. 2597 01:34:48,960 --> 01:34:50,400 >> BUT MY QUESTION REALLY IS DO 2598 01:34:50,400 --> 01:34:53,760 YOU THINK OR DO OTHERS IN THE 2599 01:34:53,760 --> 01:34:58,960 GROUP HERE HAVE ANY THOUGHTS 2600 01:34:58,960 --> 01:35:01,520 ABOUT UNDERSTANDING QUALITY BY 2601 01:35:01,520 --> 01:35:03,680 DESIGN OPTIONS TO MITIGATE, TO 2602 01:35:03,680 --> 01:35:05,200 BASICALLY UNDERSTAND WHAT THE 2603 01:35:05,200 --> 01:35:07,600 ROOT CAUSES ARE OF THIS -- WHEN 2604 01:35:07,600 --> 01:35:11,440 WE SEE OVER 10% MISSING DATA, IN 2605 01:35:11,440 --> 01:35:13,200 TRIALS AND INDUSTRY, THAT IS A 2606 01:35:13,200 --> 01:35:13,880 BIG FLAG. 2607 01:35:13,880 --> 01:35:15,440 AND WE TRY AND UNDERSTAND THAT 2608 01:35:15,440 --> 01:35:16,720 EARLY IN THE TRIALS. 2609 01:35:16,720 --> 01:35:20,160 WE'RE SEEING 10% IN THE FIRST 2610 01:35:20,160 --> 01:35:21,080 20% ENROLLED, WE JUMP IN AND 2611 01:35:21,080 --> 01:35:22,720 START TO DO SOMETHING FOR THE 2612 01:35:22,720 --> 01:35:24,840 REST OF THE 80% SO WE'RE NOT 2613 01:35:24,840 --> 01:35:26,200 GETTING THAT MISSING DATA. 2614 01:35:26,200 --> 01:35:27,400 HERE WE'RE SEEING IT KIND OF AT 2615 01:35:27,400 --> 01:35:30,280 THE END OF THE TRIAL BUT I 2616 01:35:30,280 --> 01:35:31,760 UNDERSTAND NCI TRIALS ARE 2617 01:35:31,760 --> 01:35:32,920 DIFFERENT THAN INDUSTRY TRIALS 2618 01:35:32,920 --> 01:35:34,520 BECAUSE OF, YOU KNOW, THE 2619 01:35:34,520 --> 01:35:36,200 MONITORING FREQUENCY AND ALL 2620 01:35:36,200 --> 01:35:39,320 THAT AND ABILITY TO REACT TO 2621 01:35:39,320 --> 01:35:40,640 DATA. 2622 01:35:40,640 --> 01:35:42,160 BUT I'M JUST CONCERNED ABOUT 2623 01:35:42,160 --> 01:35:45,680 WHAT'S GOING ON NOW IN TODAY'S 2624 01:35:45,680 --> 01:35:46,640 TRIALS WITH THE DECENTRALIZATION 2625 01:35:46,640 --> 01:35:50,800 BECAUSE OF THE COVID AND THE 2626 01:35:50,800 --> 01:35:52,880 CHALLENGES OF DROPOUTS. 2627 01:35:52,880 --> 01:35:54,720 YOU KNOW, ARE THINGS GOING TO 2628 01:35:54,720 --> 01:35:55,800 GET BETTER OR WORSE? 2629 01:35:55,800 --> 01:35:58,640 IS IT REALLY TIME TO START 2630 01:35:58,640 --> 01:36:02,800 THINKING ABOUT WAYS THAT WE CAN 2631 01:36:02,800 --> 01:36:04,320 BETTER INSTITUTE WHAT WE CALL 2632 01:36:04,320 --> 01:36:05,680 QUALITY BY DESIGN FOR THESE 2633 01:36:05,680 --> 01:36:07,480 KINDS OF ISSUES? 2634 01:36:07,480 --> 01:36:09,600 >> WELL, AS ELECTRA SAID WE 2635 01:36:09,600 --> 01:36:11,200 WOULD BE VERY INTERESTED IN 2636 01:36:11,200 --> 01:36:14,280 UNDERSTANDING WAYS YOU'VE TRIED 2637 01:36:14,280 --> 01:36:15,640 TO ASSESS AND TRIED TO FIGURE 2638 01:36:15,640 --> 01:36:17,840 OUT WHY THERE ARE SO MANY 2639 01:36:17,840 --> 01:36:19,440 UNKNOWNS, WHAT LEADS TO THAT, 2640 01:36:19,440 --> 01:36:20,960 HOW TO CORRECT THAT AS MUCH AS 2641 01:36:20,960 --> 01:36:21,720 POSSIBLE. 2642 01:36:21,720 --> 01:36:28,560 WE SEE IN LARGER STUDIES, PHASE 2643 01:36:28,560 --> 01:36:30,480 3 CLINICAL TRIALS HAVE A 2644 01:36:30,480 --> 01:36:31,360 DIFFERENT PERCENTAGE BUT STILL 2645 01:36:31,360 --> 01:36:39,240 BETWEEN 3 1/2 TO 4 1/2%, WE 2646 01:36:39,240 --> 01:36:43,480 WOULD LIKE TO KNOW ACROSS 2647 01:36:43,480 --> 01:36:44,920 CLINICAL RESEARCH AND TRY TO 2648 01:36:44,920 --> 01:36:46,120 CORRECT THAT, VERY HELPFUL TO 2649 01:36:46,120 --> 01:36:48,640 UNDERSTAND AND GET YOUR INPUT. 2650 01:36:48,640 --> 01:36:49,240 >> THANKS. 2651 01:36:49,240 --> 01:36:51,080 THERE ARE A COUPLE OF OTHER -- 2652 01:36:51,080 --> 01:36:52,800 WE'RE A COUPLE MINUTES OVER. 2653 01:36:52,800 --> 01:36:57,360 BOY, THIS IS AN IMPORTANT 2654 01:36:57,360 --> 01:36:57,640 DISCUSSION. 2655 01:36:57,640 --> 01:36:59,200 WE'RE GOING TO EAT INTO OUR 2656 01:36:59,200 --> 01:37:00,360 BREAK PROBABLY. 2657 01:37:00,360 --> 01:37:06,640 FOR ME, IT'S ALWAYS GOOD TO SEE 2658 01:37:06,640 --> 01:37:07,840 THERAPEUTIC VERSUS 2659 01:37:07,840 --> 01:37:08,200 NON-THERAPEUTIC. 2660 01:37:08,200 --> 01:37:10,320 THAT'S WHERE WE START TO SEE 2661 01:37:10,320 --> 01:37:11,480 HUGE DIFFERENCES AND SOME 2662 01:37:11,480 --> 01:37:13,880 DISPARITIES, WHERE THEY JUMP 2663 01:37:13,880 --> 01:37:14,040 OUT. 2664 01:37:14,040 --> 01:37:17,800 AND WITHOUT SEEING IT, YOU KNOW, 2665 01:37:17,800 --> 01:37:19,960 YOU CAN GET A FALSE IMPRESSION 2666 01:37:19,960 --> 01:37:26,120 OF SORTS THAT THERE ARE NO 2667 01:37:26,120 --> 01:37:26,760 DISPARITIES AND MINORITY 2668 01:37:26,760 --> 01:37:27,280 PARTICIPATION IN TRIALS. 2669 01:37:27,280 --> 01:37:29,280 I DON'T KNOW IF IT'S POSSIBLE -- 2670 01:37:29,280 --> 01:37:31,480 I KNOW THERE'S ONLY SO MUCH TIME 2671 01:37:31,480 --> 01:37:32,720 BUT AT SOME POINT IT WOULD BE 2672 01:37:32,720 --> 01:37:38,680 GREAT TO SEE THERAPEUTIC VERSUS 2673 01:37:38,680 --> 01:37:40,600 NON-THERAPEUTIC PARTICULARLY 2674 01:37:40,600 --> 01:37:42,400 CONSIDERING RACE, GENDER, AGE. 2675 01:37:42,400 --> 01:37:46,880 ASHANI HAS A QUESTION ABOUT AGE. 2676 01:37:46,880 --> 01:37:47,880 >> I SEE THERE'S AN ANSWER IN 2677 01:37:47,880 --> 01:37:49,880 THE CHAT THAT I HAVEN'T HAD A 2678 01:37:49,880 --> 01:37:52,880 CHANCE TO READ YET. 2679 01:37:52,880 --> 01:37:53,160 >> OKAY. 2680 01:37:53,160 --> 01:37:55,800 >> WHICH WAS ASKING ABOUT JAMA 2681 01:37:55,800 --> 01:37:57,960 ONCOLOGY PUBLISHED A STUDY 2682 01:37:57,960 --> 01:37:59,840 SHOWING MOST NCI CLINICAL 2683 01:37:59,840 --> 01:38:02,280 TRIALS, AVERAGE PATIENT AGE IS 2684 01:38:02,280 --> 01:38:04,960 ALMOST A DECADE YOUNGER THAN THE 2685 01:38:04,960 --> 01:38:05,640 PATIENT POPULATION. 2686 01:38:05,640 --> 01:38:07,360 AND THAT'S AN ISSUE BECAUSE WE 2687 01:38:07,360 --> 01:38:08,960 KNOW THAT YOUNGER PATIENTS AND 2688 01:38:08,960 --> 01:38:10,160 OLDER PATIENTS RESPOND VERY 2689 01:38:10,160 --> 01:38:11,560 DIFFERENTLY EVEN TO THINGS LIKE 2690 01:38:11,560 --> 01:38:13,600 TARGETED THERAPY. 2691 01:38:13,600 --> 01:38:16,160 SO I'LL READ THE ANSWER IN THE 2692 01:38:16,160 --> 01:38:16,480 CHAT. 2693 01:38:16,480 --> 01:38:16,920 >> GREAT. 2694 01:38:16,920 --> 01:38:18,960 >> YEAH, ONE THING I DIDN'T HAVE 2695 01:38:18,960 --> 01:38:21,200 TIME TO EXPLAIN, THERE WAS 2696 01:38:21,200 --> 01:38:23,600 INCLUSION ACROSS THE LIFESPAN. 2697 01:38:23,600 --> 01:38:24,880 SO FUTURE REPORTS, WE WILL BE 2698 01:38:24,880 --> 01:38:26,120 REPORTING ON AGE AND BE ABLE TO 2699 01:38:26,120 --> 01:38:29,920 GIVE YOU MORE OF THAT BREAKDOWN. 2700 01:38:29,920 --> 01:38:31,160 I KNOW WITHIN INDIVIDUAL 2701 01:38:31,160 --> 01:38:33,080 PROGRAMS ACROSS THE NCI WE LOOK 2702 01:38:33,080 --> 01:38:34,800 AT EACH FIGURE YOU WERE TALKING 2703 01:38:34,800 --> 01:38:38,320 ABOUT TO SEE, AGAIN, HOW 2704 01:38:38,320 --> 01:38:42,600 REPRESENTATIVE WE ARE OF THE 2705 01:38:42,600 --> 01:38:43,320 PATIENT POPULATION. 2706 01:38:43,320 --> 01:38:46,720 >> SO THIS IS -- THANKS, MEG. 2707 01:38:46,720 --> 01:38:47,640 THIS IS A REPORT. 2708 01:38:47,640 --> 01:38:50,960 AS A BOARD WE HAVE TO CALL A 2709 01:38:50,960 --> 01:38:53,880 VOTE TO APPROVE THE REPORT THAT 2710 01:38:53,880 --> 01:38:54,320 WAS PRESENTED. 2711 01:38:54,320 --> 01:38:56,680 SO DO WE HAVE A MOTION -- 2712 01:38:56,680 --> 01:38:58,640 >> NOT TO APPROVE THE REPORT, TO 2713 01:38:58,640 --> 01:38:59,600 ACCEPT THE REPORT. 2714 01:38:59,600 --> 01:39:00,800 >> TO ACCEPT THE REPORT. 2715 01:39:00,800 --> 01:39:02,040 TO ACCEPT THE REPORT. 2716 01:39:02,040 --> 01:39:05,240 DO WE HAVE A MOTION TO ACCEPT 2717 01:39:05,240 --> 01:39:07,000 THIS REPORT THAT WAS JUST 2718 01:39:07,000 --> 01:39:08,840 PRESENTED. 2719 01:39:08,840 --> 01:39:09,440 >> SO MOVED. 2720 01:39:09,440 --> 01:39:09,800 >> SECOND? 2721 01:39:09,800 --> 01:39:11,720 MOVE TO SECOND. 2722 01:39:11,720 --> 01:39:14,600 WE SHOULD VOTE. 2723 01:39:14,600 --> 01:39:14,880 DISCUSSION? 2724 01:39:14,880 --> 01:39:15,400 WE SHOULD VOTE. 2725 01:39:15,400 --> 01:39:19,280 CAN I SEE THE HANDS FOR YAY. 2726 01:39:19,280 --> 01:39:23,240 2727 01:39:23,240 --> 01:39:23,440 OKAY. 2728 01:39:23,440 --> 01:39:27,200 ANY HANDS FOR NAY? 2729 01:39:27,200 --> 01:39:27,800 2730 01:39:27,800 --> 01:39:30,000 2731 01:39:30,000 --> 01:39:30,720 ANY ABSTENTIONS? 2732 01:39:30,720 --> 01:39:32,800 OKAY. 2733 01:39:32,800 --> 01:39:33,200 THE YAYS HAVE IT. 2734 01:39:33,200 --> 01:39:35,960 >> THANK YOU VERY MUCH. 2735 01:39:35,960 --> 01:39:38,280 >> THANK YOU, MEG. 2736 01:39:38,280 --> 01:39:39,800 NEXT WE HAVE FINAL PRESENTATION 2737 01:39:39,800 --> 01:39:44,240 FOR THIS PART OF THE MEETING, 2738 01:39:44,240 --> 01:39:44,840 THE NATURAL PRODUCTS PROGRAM 2739 01:39:44,840 --> 01:39:48,640 GIVEN BY DR. BARRY O'KEEFE, 2740 01:39:48,640 --> 01:39:50,400 DIRECTOR FOR MOLECULAR TARGETS 2741 01:39:50,400 --> 01:39:50,760 PROGRAM. 2742 01:39:50,760 --> 01:39:55,600 THE CENTER FOR CANCER RESEARCH. 2743 01:39:55,600 --> 01:39:56,200 NATURAL PRODUCTS BRANCH, 2744 01:39:56,200 --> 01:39:57,040 DEVELOPMENTAL THERAPEUTICS 2745 01:39:57,040 --> 01:39:58,440 PROGRAM DIVISION OF CANCER 2746 01:39:58,440 --> 01:40:01,720 TREATMENT AND DIAGNOSIS. 2747 01:40:01,720 --> 01:40:01,920 BARRY? 2748 01:40:01,920 --> 01:40:05,120 >> THANK YOU VERY MUCH FOR THIS 2749 01:40:05,120 --> 01:40:07,040 OPPORTUNITY TO GET ADVICE OF THE 2750 01:40:07,040 --> 01:40:11,280 BOARD AND INPUT ON THIS PROGRAM, 2751 01:40:11,280 --> 01:40:13,200 THE NCI HAS INITIATED. 2752 01:40:13,200 --> 01:40:16,800 AS MANY OF YOU ARE FAMILIAR, 2753 01:40:16,800 --> 01:40:20,240 NATURAL PRODUCTS MADE 2754 01:40:20,240 --> 01:40:21,840 SIGNIFICANT CONTRIBUTION, I'M 2755 01:40:21,840 --> 01:40:22,520 SHOWING DIVERSE CHEMICAL 2756 01:40:22,520 --> 01:40:24,200 STRUCTURES THAT RESULT FROM 2757 01:40:24,200 --> 01:40:26,080 NATURAL PRODUCTS STUDIES 2758 01:40:26,080 --> 01:40:27,040 APPROVED AS ANTI-CANCER AGENTS 2759 01:40:27,040 --> 01:40:29,720 OVER THE LAST 10 TO 15 YEARS, 2760 01:40:29,720 --> 01:40:34,960 LOOKING AT THE TOTALITY OF 2761 01:40:34,960 --> 01:40:36,120 NATURAL PRODUCTS, SMALL MOLECULE 2762 01:40:36,120 --> 01:40:38,400 SCAFFOLD USE IN THE 2763 01:40:38,400 --> 01:40:39,480 PHARMACOPEIA, APPROVED DRUGS FOR 2764 01:40:39,480 --> 01:40:41,400 ALL USES NATURAL PRODUCTS MAKE 2765 01:40:41,400 --> 01:40:46,040 UP 25 TO 30% ON AVERAGE OVER THE 2766 01:40:46,040 --> 01:40:46,240 YEARS. 2767 01:40:46,240 --> 01:40:47,880 WHICH IS SIGNIFICANT IMPACT. 2768 01:40:47,880 --> 01:40:52,040 HOWEVER, WHEN WE TAKE A LOOK AT 2769 01:40:52,040 --> 01:40:52,880 CURRENT LEVEL OF HIGH-THROUGHPUT 2770 01:40:52,880 --> 01:40:54,280 SCREENING, ONE OF THE MAIN 2771 01:40:54,280 --> 01:40:56,560 AVENUES BY WHICH SMALL MOLECULES 2772 01:40:56,560 --> 01:40:57,600 ARE DISCOVERED AND BECOME 2773 01:40:57,600 --> 01:41:00,840 POTENTIAL LEAD AVENUES FOR 2774 01:41:00,840 --> 01:41:03,480 DRUGS, WE SEE THAT 2775 01:41:03,480 --> 01:41:04,680 HIGH-THROUGHPUT SCREENING 2776 01:41:04,680 --> 01:41:05,920 INCREASED SIGNIFICANTLY THIS 2777 01:41:05,920 --> 01:41:07,960 CENTURY, HAVE NOT SEEN SIMILAR 2778 01:41:07,960 --> 01:41:10,240 INCREASE IN AMOUNT OF NATURAL 2779 01:41:10,240 --> 01:41:14,200 PRODUCTS INCLUDED IN ASSAYS, IN 2780 01:41:14,200 --> 01:41:16,840 BLUE ONLY A SMALL PERCENTAGE, 1% 2781 01:41:16,840 --> 01:41:18,440 INCLUDE NATURAL PRODUCT SAMPLES. 2782 01:41:18,440 --> 01:41:19,520 WHY IS THIS? 2783 01:41:19,520 --> 01:41:22,080 THERE'S SEVERAL REASONS. 2784 01:41:22,080 --> 01:41:25,360 THIS IMAGE SHOWS CLASSIC 2785 01:41:25,360 --> 01:41:28,040 EXAMPLE, THIS IS PLATE OF 96 2786 01:41:28,040 --> 01:41:32,960 CRUDE NATURAL PRODUCT EXTRACTS, 2787 01:41:32,960 --> 01:41:35,400 DIFFICULT TO SCREEN, CONTAIN 2788 01:41:35,400 --> 01:41:36,800 NUMEROUS POUNDS FOUND AT 2789 01:41:36,800 --> 01:41:38,520 DIFFERENT CONCENTRATIONS. 2790 01:41:38,520 --> 01:41:40,200 ALSO THE PURIFICATION AND 2791 01:41:40,200 --> 01:41:43,800 STRUCTURAL ELUCIDATION OF THE 2792 01:41:43,800 --> 01:41:44,960 ACTIVE COMPONENTS WITHIN 2793 01:41:44,960 --> 01:41:49,120 EXTRACTS WAS TIME CONSUMING AND 2794 01:41:49,120 --> 01:41:50,440 DIDN'T MESH WELL WITH 2795 01:41:50,440 --> 01:41:50,960 HIGH-THROUGHPUT SCREENING 2796 01:41:50,960 --> 01:41:53,480 SCHEDULES RESULTING IN A SLOW 2797 01:41:53,480 --> 01:41:54,800 PROCESS INCREASING COSTS IN THE 2798 01:41:54,800 --> 01:41:56,560 CHEMISTRY SIDE OF THINGS AS WELL 2799 01:41:56,560 --> 01:41:57,960 AS SCREENING SIDE OF THINGS 2800 01:41:57,960 --> 01:42:00,160 WHERE ASSAYS HAD TO BE KEPT UP 2801 01:42:00,160 --> 01:42:01,360 FOR LONG PERIODS OF TIME. 2802 01:42:01,360 --> 01:42:03,960 AND SO THERE WAS A NEED TO 2803 01:42:03,960 --> 01:42:05,960 ADDRESS THESE CHALLENGES IN 2804 01:42:05,960 --> 01:42:07,720 ORDER TO EFFICIENTLY ACCESS THE 2805 01:42:07,720 --> 01:42:10,160 CHEMICAL DIVERSITY AND NATURAL 2806 01:42:10,160 --> 01:42:10,400 PRODUCTS. 2807 01:42:10,400 --> 01:42:12,880 AND WHY WOULD THE NCI BE 2808 01:42:12,880 --> 01:42:13,200 INTERESTED? 2809 01:42:13,200 --> 01:42:16,440 THE NCI HAS ONE OF THE LARGEST 2810 01:42:16,440 --> 01:42:17,560 LIBRARIES OF CRUDE NATURAL 2811 01:42:17,560 --> 01:42:22,440 PRODUCT EXTRACTS IN THE WORLD. 2812 01:42:22,440 --> 01:42:26,160 A MAP DEPICTS WHERE COLLECTED, 2813 01:42:26,160 --> 01:42:30,240 230,000 IN THE LIBRARY, ORIGINS 2814 01:42:30,240 --> 01:42:32,040 FROM PLANTS, MARINE ORGANISMS, 2815 01:42:32,040 --> 01:42:32,960 MICROBIAL SOURCE ORGANISMS AS 2816 01:42:32,960 --> 01:42:33,240 WELL. 2817 01:42:33,240 --> 01:42:40,200 WE HAD A LARGE LIBRARY OF CRUDE 2818 01:42:40,200 --> 01:42:41,120 EXTRACTS BUT FEWER PEOPLE 2819 01:42:41,120 --> 01:42:44,440 INTERESTED IN SCREENING THEM. 2820 01:42:44,440 --> 01:42:57,280 THE NCI INSTIGATED A 2821 01:42:57,280 --> 01:43:00,360 COLLABORATION. 2822 01:43:00,360 --> 01:43:01,120 AND THE NPNPD FACILITATES 2823 01:43:01,120 --> 01:43:03,080 INTRAMURAL AND EXTRAMURAL 2824 01:43:03,080 --> 01:43:04,400 RESEARCH AND ADDRESSING 2825 01:43:04,400 --> 01:43:05,400 CHALLENGES IN DRUG DISCOVERY 2826 01:43:05,400 --> 01:43:07,800 FUNDED BY THE CANCER MOONSHOT 2827 01:43:07,800 --> 01:43:08,960 PROGRAM, A MULTI-FACETED PROGRAM 2828 01:43:08,960 --> 01:43:12,800 AS SHOWN IN THIS DIAGRAM IN THE 2829 01:43:12,800 --> 01:43:13,040 CENTER. 2830 01:43:13,040 --> 01:43:15,440 IT HAS SEVERAL SPECIFIC AIMS 2831 01:43:15,440 --> 01:43:17,840 WHICH I'M SHARING HERE. 2832 01:43:17,840 --> 01:43:23,920 PRIMARILY INITIALLY TO CREATE A 2833 01:43:23,920 --> 01:43:29,640 PRE-FRACTIONATED OR SEMI 2834 01:43:29,640 --> 01:43:31,960 PURIFIED HIGH-THROUGHPUT, TO 2835 01:43:31,960 --> 01:43:37,960 EXPAND AVAILABLE FROM CULTURABLE 2836 01:43:37,960 --> 01:43:38,520 ORGANISMS. 2837 01:43:38,520 --> 01:43:41,640 WE WERE GOING TO PROVIDE THIS 2838 01:43:41,640 --> 01:43:43,880 PRE-FRACTIONATED LIBRARY TO 2839 01:43:43,880 --> 01:43:44,760 SCREENING CENTERS WORLDWIDE FOR 2840 01:43:44,760 --> 01:43:44,960 FREE. 2841 01:43:44,960 --> 01:43:47,160 WE ALSO WERE GOING TO ENCOURAGE 2842 01:43:47,160 --> 01:43:48,160 THE HIGH-THROUGHPUT SCREENING 2843 01:43:48,160 --> 01:43:49,800 SUPPORT FOR RESEARCHERS TO 2844 01:43:49,800 --> 01:43:53,040 ENABLE THIS, PARTLY BY PROVIDING 2845 01:43:53,040 --> 01:43:58,160 FASTER ANALYTICAL RESOURCES, 2846 01:43:58,160 --> 01:44:00,720 ISOLATION, STRUCTURAL 2847 01:44:00,720 --> 01:44:01,640 ELUCIDATION, TO EXPEDITE PIPE 2848 01:44:01,640 --> 01:44:04,680 LINES AND PULL THIS AGO IN A 2849 01:44:04,680 --> 01:44:05,920 BIOINFORMATICS AND DATABASES TO 2850 01:44:05,920 --> 01:44:06,800 INCREASE EFFICIENCY OF THE 2851 01:44:06,800 --> 01:44:10,280 PROGRAM BUT ALSO TO BROADEN 2852 01:44:10,280 --> 01:44:13,640 INPUT AND IMPACT. 2853 01:44:13,640 --> 01:44:16,200 SO, THE FIRST THING WAS 2854 01:44:16,200 --> 01:44:16,960 PRE-FRACTIONATION PLANS. 2855 01:44:16,960 --> 01:44:18,680 THIS IS IN THIS CASE, WE WERE 2856 01:44:18,680 --> 01:44:20,880 SET OUT TO MAKE A LIBRARY OF A 2857 01:44:20,880 --> 01:44:23,160 MILLION SEMI PURE AND NATURAL 2858 01:44:23,160 --> 01:44:24,400 PRODUCT FRACTIONS, SUPPLY THIS 2859 01:44:24,400 --> 01:44:27,600 TO RESEARCHES FOR FREE IN PLATED 2860 01:44:27,600 --> 01:44:28,400 AND 384 WELL PLATES 2861 01:44:28,400 --> 01:44:30,920 AND OPEN THE USE OF THIS LIBRARY 2862 01:44:30,920 --> 01:44:32,960 FOR ALL SCREENING LABS AGAINST 2863 01:44:32,960 --> 01:44:34,440 ALL DISEASE STATES, WITH THE 2864 01:44:34,440 --> 01:44:35,320 ASSUMPTION THAT WE WOULD FIND 2865 01:44:35,320 --> 01:44:41,200 OUT MORE ABOUT BASIC BIOLOGY AS 2866 01:44:41,200 --> 01:44:43,040 WELL AS CHEMISTRY THEREIN, AND 2867 01:44:43,040 --> 01:44:45,240 THAT IT MIGHT NOT SEEM IMPORTANT 2868 01:44:45,240 --> 01:44:48,400 RIGHT NOW TO CANCER AS CANCER 2869 01:44:48,400 --> 01:44:49,080 BIOLOGY DEVELOPS OVER THE YEARS, 2870 01:44:49,080 --> 01:44:51,800 20 YEARS FROM NOW THAT COULD BE 2871 01:44:51,800 --> 01:44:54,240 AN IMPORTANT TARGET FOR CANCER. 2872 01:44:54,240 --> 01:44:56,360 AND THEN WE WANTED TO MAKE SURE 2873 01:44:56,360 --> 01:44:58,040 THIS LIBRARY WOULDN'T IMPROVE 2874 01:44:58,040 --> 01:45:00,400 ONLY THE EFFICIENCY OF SCREENING 2875 01:45:00,400 --> 01:45:01,800 BUT ALSO OF DOWNSTREAM CHEMISTRY 2876 01:45:01,800 --> 01:45:02,240 EFFORTS. 2877 01:45:02,240 --> 01:45:03,480 SO THERE'S A LOT OF METHOD 2878 01:45:03,480 --> 01:45:04,920 DEVELOPMENT WHICH I WON'T GO 2879 01:45:04,920 --> 01:45:06,960 INTO IN DETAIL HERE BUT JUST TO 2880 01:45:06,960 --> 01:45:09,560 GIVE YOU A FEW BULLET POINTS, 2881 01:45:09,560 --> 01:45:11,800 THE PURIFICATION OF THESE 2882 01:45:11,800 --> 01:45:13,960 EXTRACTS IS BASED ON CHEMICAL 2883 01:45:13,960 --> 01:45:16,920 POLARITY, FOR YIELD OF MASS, 2884 01:45:16,920 --> 01:45:17,920 COMPOUND SEPARATION, BIOLOGICAL 2885 01:45:17,920 --> 01:45:22,760 ACTIVITY RETENTION AND A SYSTEM 2886 01:45:22,760 --> 01:45:23,680 THAT COULD PRODUCE 150,000 A 2887 01:45:23,680 --> 01:45:25,600 YEAR, TEN TIMES WHAT ANYBODY HAD 2888 01:45:25,600 --> 01:45:26,640 TRIED TO DO BEFORE. 2889 01:45:26,640 --> 01:45:28,600 AND WE ALSO NEEDED TO DO THAT 2890 01:45:28,600 --> 01:45:29,960 WITH SUFFICIENT MASS TO SUPPORT 2891 01:45:29,960 --> 01:45:31,600 A SCREENING PROGRAM FOR AT LEAST 2892 01:45:31,600 --> 01:45:32,240 A DECADE. 2893 01:45:32,240 --> 01:45:35,280 AND THEN WE ALSO NEEDED TO HAVE 2894 01:45:35,280 --> 01:45:37,400 THIS IN AN AUTOMATED SYSTEM SO 2895 01:45:37,400 --> 01:45:42,080 IT WAS EASILY AND FACILELY 2896 01:45:42,080 --> 01:45:46,120 ACCESSED AS RESEARCH MOVED 2897 01:45:46,120 --> 01:45:47,080 FORWARD OVER ENSUING YEARS. 2898 01:45:47,080 --> 01:45:48,960 THIS WAS TAKING THE WAY NATURAL 2899 01:45:48,960 --> 01:45:50,440 PRODUCTS HAD BEEN DONE FOR THE 2900 01:45:50,440 --> 01:45:55,880 LAST 50 TO 100 YEARS, WHICH WAS 2901 01:45:55,880 --> 01:45:57,920 SLOW, INDIVIDUAL COLUMNS, 2902 01:45:57,920 --> 01:46:00,080 RESEARCHESSERS, TURNING IT INTO 2903 01:46:00,080 --> 01:46:01,520 SOMETHING AUTOMATED AND AMENABLE 2904 01:46:01,520 --> 01:46:05,240 TO MODERN DRUG DISCOVERY 2905 01:46:05,240 --> 01:46:05,520 PARADIGMS. 2906 01:46:05,520 --> 01:46:08,920 SO TO MAKE A LONG STORY SHORT WE 2907 01:46:08,920 --> 01:46:10,000 OPTIMIZED EVERYTHING AND 2908 01:46:10,000 --> 01:46:12,000 AUTOMATED EVERYTHING TO A LARGE 2909 01:46:12,000 --> 01:46:12,600 EXTENT. 2910 01:46:12,600 --> 01:46:15,480 HERE I'M SHOWING A VARIETY OF 2911 01:46:15,480 --> 01:46:16,240 INSTRUMENTATION WE HAD TO MODIFY 2912 01:46:16,240 --> 01:46:18,000 TO BE ABLE TO USE FOR THE 2913 01:46:18,000 --> 01:46:18,240 SYSTEM. 2914 01:46:18,240 --> 01:46:20,920 SO THE FOLKS IN THE LAB ACTUALLY 2915 01:46:20,920 --> 01:46:23,200 MODIFIED A VARIETY OF ROBOTIC 2916 01:46:23,200 --> 01:46:25,080 SYSTEMS TO HANDLE THESE NEW 2917 01:46:25,080 --> 01:46:26,640 TASKS, I'D LIKE TO SAY HERE 2918 01:46:26,640 --> 01:46:28,520 SHOWING THAT THIS WAS HIGHLY 2919 01:46:28,520 --> 01:46:29,800 REPRODUCIBLE WHICH WAS VERY 2920 01:46:29,800 --> 01:46:31,040 IMPORTANT THAT WE COULD DO THIS 2921 01:46:31,040 --> 01:46:32,120 ONE MONTH AND DO THE SAME THING 2922 01:46:32,120 --> 01:46:34,520 A MONTH LATER AND GET THE SAME 2923 01:46:34,520 --> 01:46:34,880 RESULTS. 2924 01:46:34,880 --> 01:46:37,600 SO WHAT I'M SHOWING IN GRAPH A 2925 01:46:37,600 --> 01:46:40,960 IS DEPICTION OF THE MASS YIELD 2926 01:46:40,960 --> 01:46:44,040 OF 88 CRUDE EXTRACTS, EACH 2927 01:46:44,040 --> 01:46:45,680 PRE-FRACTIONATED, A MONTH LATER 2928 01:46:45,680 --> 01:46:46,400 PRE-FRACTIONATED AGAIN. 2929 01:46:46,400 --> 01:46:48,880 YOU CAN SEE WE GET A 2930 01:46:48,880 --> 01:46:50,960 REPRODUCIBLE MASS YIELD IN THE 2931 01:46:50,960 --> 01:46:52,680 INDIVIDUAL FRACTIONS. 2932 01:46:52,680 --> 01:46:54,400 SIMILARLY WE TESTED FRACTIONS 2933 01:46:54,400 --> 01:46:56,240 FOR BIOLOGICAL ACTIVITY IN THE 2934 01:46:56,240 --> 01:47:00,120 NCI 60 ASSAY AND AGAIN THEY HAD 2935 01:47:00,120 --> 01:47:00,960 HIGHLY REPRODUCIBLE ACTIVITY 2936 01:47:00,960 --> 01:47:01,360 PROFILES. 2937 01:47:01,360 --> 01:47:04,200 FOLLOW THAT UP, WE ALSO WANTED 2938 01:47:04,200 --> 01:47:04,960 TO DO PRINCIPAL COMPONENT 2939 01:47:04,960 --> 01:47:06,400 ANALYSIS TO GET AN IDEA HOW MANY 2940 01:47:06,400 --> 01:47:08,240 PURE COMPOUND WERE IN THESE 2941 01:47:08,240 --> 01:47:08,760 FRACTIONS. 2942 01:47:08,760 --> 01:47:13,040 WHAT WOULD PEOPLE BE LOOKING AT. 2943 01:47:13,040 --> 01:47:16,160 WE GENERALLY USE TOTAL MASS 2944 01:47:16,160 --> 01:47:17,960 SPECTROMETRY AS OUR MEASURE, 2945 01:47:17,960 --> 01:47:19,760 IT'S PROBABLY THE MOST ACCURATE, 2946 01:47:19,760 --> 01:47:20,720 THE LARGEST. 2947 01:47:20,720 --> 01:47:22,440 WE SEPARATE THINGS INTO SEVEN 2948 01:47:22,440 --> 01:47:23,640 FRACTIONS FOR EACH CRUDE EXTRACT 2949 01:47:23,640 --> 01:47:27,600 AND THERE'S AN AVERAGE OF 20 TO 2950 01:47:27,600 --> 01:47:30,360 25 COMPOUNDS PER FRACTION IN 2951 01:47:30,360 --> 01:47:31,840 GENERAL. 2952 01:47:31,840 --> 01:47:33,600 SO THEN AT THIS POINT WHERE ARE 2953 01:47:33,600 --> 01:47:34,000 WE? 2954 01:47:34,000 --> 01:47:39,560 WE HAVE NOW PRODUCED OVER 525, 2955 01:47:39,560 --> 01:47:42,360 000 NATURAL PRODUCT FRACTIONS, 2956 01:47:42,360 --> 01:47:44,400 325,000 RELEASED TO RESEARCH 2957 01:47:44,400 --> 01:47:45,320 COMMUNITY, ANTICIPATE 175,000 2958 01:47:45,320 --> 01:47:47,720 RELEASED WITHIN THE NEXT SIX 2959 01:47:47,720 --> 01:47:48,600 WEEKS. 2960 01:47:48,600 --> 01:47:50,240 AND WE HAVE CREATED AND PLATED 2961 01:47:50,240 --> 01:47:51,400 OVER 20 MILLION WELLS OF THESE 2962 01:47:51,400 --> 01:47:53,800 TO BE READY TO SHIP TO SCREENING 2963 01:47:53,800 --> 01:47:55,800 CENTERS AND HAVE ACTUALLY 2964 01:47:55,800 --> 01:47:57,280 SHIPPED OVER 5 MILLION SAMPLES 2965 01:47:57,280 --> 01:47:58,400 AT THIS POINT. 2966 01:47:58,400 --> 01:48:00,000 WHICH WAS GREATER THAN THE 2967 01:48:00,000 --> 01:48:02,760 PREVIOUS 40 YEARS OF NATURAL 2968 01:48:02,760 --> 01:48:03,960 PRODUCT BRANCH SHIPMENTS 2969 01:48:03,960 --> 01:48:10,200 COMBINED, ABOUT AN AVERAGE OF 2970 01:48:10,200 --> 01:48:12,520 150 FRACTIONS GOING OUT PER 2971 01:48:12,520 --> 01:48:14,240 MONTH. 2972 01:48:14,240 --> 01:48:17,840 WE HAVE PUBLICATIONS ON METHOD, 2973 01:48:17,840 --> 01:48:20,600 LIBRARY, AND HOW TO USE IN 2974 01:48:20,600 --> 01:48:22,800 CELL-BASED AND CELL-FREE 2975 01:48:22,800 --> 01:48:23,320 SCREENS. 2976 01:48:23,320 --> 01:48:26,160 IMPORTANTLY, THE ADAPTATION OF 2977 01:48:26,160 --> 01:48:29,240 THIS METHOD AND TECHNOLOGY MADE 2978 01:48:29,240 --> 01:48:30,280 AVAILABLE, IMPORTANT TO GET 2979 01:48:30,280 --> 01:48:32,200 OTHERS TO USE SYSTEMS. 2980 01:48:32,200 --> 01:48:33,960 THE AUTOMATED ROBOTIC SYSTEM IN 2981 01:48:33,960 --> 01:48:35,800 THE UPPER RIGHT-HAND CORNER 2982 01:48:35,800 --> 01:48:37,200 HERE, FOR EXAMPLE, WE WORKED 2983 01:48:37,200 --> 01:48:40,280 WITH A GROUP IN SOUTH AFRICA 2984 01:48:40,280 --> 01:48:42,240 THAT HAD 30 TO 40,000 NATIVE 2985 01:48:42,240 --> 01:48:43,360 PLANTS FROM SOUTH AFRICA THAT 2986 01:48:43,360 --> 01:48:45,400 THEY HAVE NOW PUT THROUGH THE 2987 01:48:45,400 --> 01:48:45,720 SAME SYSTEMS. 2988 01:48:45,720 --> 01:48:46,960 WE'VE BEEN WORKING WITH THEM. 2989 01:48:46,960 --> 01:48:50,440 THEY RECENTLY HAD A GRANT HIGHLY 2990 01:48:50,440 --> 01:48:53,960 RATED FOR USE FOR DISEASES OF 2991 01:48:53,960 --> 01:48:55,040 IMPORTANCE TO AFRICA, IN 2992 01:48:55,040 --> 01:48:59,200 COLLABORATION WITH PEOPLE IN 2993 01:48:59,200 --> 01:49:00,160 SOUTH AFRICA, CAMEROON, 2994 01:49:00,160 --> 01:49:00,480 TANZANIA. 2995 01:49:00,480 --> 01:49:02,720 WE ALSO WANT TO EXPAND CHEMICAL 2996 01:49:02,720 --> 01:49:03,640 DIVERSITY FROM CULTURAL 2997 01:49:03,640 --> 01:49:04,080 ORGANISMS. 2998 01:49:04,080 --> 01:49:05,760 WE'VE DONE THIS THROUGH A 2999 01:49:05,760 --> 01:49:07,480 CITIZEN SCIENCE PROGRAM 3000 01:49:07,480 --> 01:49:09,800 COLLABORATION WITH UNIVERSITY OF 3001 01:49:09,800 --> 01:49:10,680 OKLAHOMA WHICH BROUGHT 24,000 3002 01:49:10,680 --> 01:49:11,840 FUNGAL SAMPLES TO THE NCI. 3003 01:49:11,840 --> 01:49:13,600 I'M SHOWING A MAP OF WHERE THESE 3004 01:49:13,600 --> 01:49:15,360 ARE FROM IN THE UNITED STATES. 3005 01:49:15,360 --> 01:49:17,440 WE ALSO HAVE A NEW FERMENTATION 3006 01:49:17,440 --> 01:49:20,960 FACILITY AT THE NCI IN FREDERICK 3007 01:49:20,960 --> 01:49:22,440 TO RAPIDLY PRODUCES THEM, GROW 3008 01:49:22,440 --> 01:49:23,960 AND EXTRACT THEM. 3009 01:49:23,960 --> 01:49:25,320 I'M SHOWING BREAKDOWN OF THE 3010 01:49:25,320 --> 01:49:28,080 TAXONOMY OF THESE ORGANISM ALSO, 3011 01:49:28,080 --> 01:49:30,120 IMPORTANTLY WE HAVE SEQUENCED 3012 01:49:30,120 --> 01:49:32,600 ALL THESE, PHOTOGRAPHED THEM, 3013 01:49:32,600 --> 01:49:34,040 CRYOVIALED THEM, TO PROVIDE 3014 01:49:34,040 --> 01:49:35,920 EXTRACTS TO RESEARCHERS BUT 3015 01:49:35,920 --> 01:49:36,800 ORGANISMS THEMSELVES AND ENSURED 3016 01:49:36,800 --> 01:49:41,560 THERE IS A GREAT AMOUNT OF 3017 01:49:41,560 --> 01:49:43,680 TAXONOMIC DIVERSITY BY REQUIRES 3018 01:49:43,680 --> 01:49:45,200 ITS SEQUENCING AND ENSURING EACH 3019 01:49:45,200 --> 01:49:46,520 ORGANISM THAT WAS ACCEPTED INTO 3020 01:49:46,520 --> 01:49:50,440 THE COLLECTION HAS TO BE 99.5% 3021 01:49:50,440 --> 01:49:53,200 DIFFERENT BY ITS SEQUENCE IN A 3022 01:49:53,200 --> 01:49:55,320 ZIP CODE IN THE UNITED STATES. 3023 01:49:55,320 --> 01:49:57,200 TO SHOW EVIDENCE FROM A PILOT 3024 01:49:57,200 --> 01:50:00,800 PROGRAM WE'VE DONE THIS SHOWS 3025 01:50:00,800 --> 01:50:02,840 CHEMICAL DIVERSITY, ALL 3026 01:50:02,840 --> 01:50:04,200 COMPONENTS THE SHOW CYTOTOXIC 3027 01:50:04,200 --> 01:50:07,000 ACTIVITY IN THE NCI 60 ASSAY, 3028 01:50:07,000 --> 01:50:10,360 THIS WAS INITIAL STUDY, PROBABLY 3029 01:50:10,360 --> 01:50:11,720 WILL PUBLISH, INFORMATION ABOUT 3030 01:50:11,720 --> 01:50:12,760 THIS LIBRARY, THIS CALENDAR 3031 01:50:12,760 --> 01:50:12,960 YEAR. 3032 01:50:12,960 --> 01:50:14,840 WE THEN WANTED TO MAKE SURE THIS 3033 01:50:14,840 --> 01:50:17,320 GOT OUT TO PEOPLE SO WE HAVE 3034 01:50:17,320 --> 01:50:21,360 PROVIDED THIS LIBRARY AT THIS 3035 01:50:21,360 --> 01:50:22,640 POINT EXECUTED MORE THAN 40 MTA 3036 01:50:22,640 --> 01:50:24,680 AGREEMENTS WITH A VARIETY OF 3037 01:50:24,680 --> 01:50:25,480 UNIVERSITIES AND RESEARCH 3038 01:50:25,480 --> 01:50:26,960 INSTITUTIONS AROUND THE COUNTRY 3039 01:50:26,960 --> 01:50:28,760 AND AROUND THE WORLD. 3040 01:50:28,760 --> 01:50:31,920 SO THAT'S ABOUT ONE MTA EVERY 3041 01:50:31,920 --> 01:50:35,000 MONTH SO FAR, SINCE THEN 3042 01:50:35,000 --> 01:50:36,120 RELEASED THE FIRST LIBRARY, HAD 3043 01:50:36,120 --> 01:50:38,680 PARTICIPATION FROM INDUSTRY AND 3044 01:50:38,680 --> 01:50:39,040 U.S. GOVERNMENT. 3045 01:50:39,040 --> 01:50:42,000 AS FAR AS U.S. GOVERNMENT 3046 01:50:42,000 --> 01:50:43,800 AGENCIES, I AM DETAILING A FEW 3047 01:50:43,800 --> 01:50:45,720 OF THESE INTERACTIONS HERE. 3048 01:50:45,720 --> 01:50:47,720 FOR EXAMPLE, WITH NIAID, WE HAVE 3049 01:50:47,720 --> 01:50:48,920 A JOINT INTERAGENCY AGREEMENT 3050 01:50:48,920 --> 01:50:50,760 NOW, AND HAVE WORKED WITH THEM 3051 01:50:50,760 --> 01:50:53,640 TO SCREEN THIS LIBRARY AGAINST 3052 01:50:53,640 --> 01:50:55,240 ESKAPE PATHOGENS FOR ANTIBIOTIC 3053 01:50:55,240 --> 01:50:55,520 DISCOVERY. 3054 01:50:55,520 --> 01:50:57,240 WE WORK WITH WALTER REED AND 3055 01:50:57,240 --> 01:51:01,240 DEPARTMENT OF DEFENSE TO LOOK AT 3056 01:51:01,240 --> 01:51:07,360 SCREENING THESE AGAINST MALARIA 3057 01:51:07,360 --> 01:51:09,440 AND LEISHMANIASIS. 3058 01:51:09,440 --> 01:51:15,200 NCCIH AND NCATS COMBINED WITH 3059 01:51:15,200 --> 01:51:16,800 THE "HEAL" PROGRAM TO SCREEN 3060 01:51:16,800 --> 01:51:18,000 THESE FRACTIONS AGAINST TARGETS 3061 01:51:18,000 --> 01:51:20,080 THAT ARE ASSOCIATED WITH THE 3062 01:51:20,080 --> 01:51:20,440 HEAL INITIATIVE. 3063 01:51:20,440 --> 01:51:22,680 AND SO WE'VE PROVIDED THE 3064 01:51:22,680 --> 01:51:23,960 LIBRARY TO NCATS, AND THEY 3065 01:51:23,960 --> 01:51:26,080 SCREEN WITH TARGETS THAT ARE 3066 01:51:26,080 --> 01:51:27,520 DERIVED FROM EXTRAMURAL 3067 01:51:27,520 --> 01:51:28,720 RESEARCHERS, AND THE NCI 3068 01:51:28,720 --> 01:51:31,720 PARTICIPATE BY ISOLATING AND 3069 01:51:31,720 --> 01:51:35,160 DIFFERENTING THE ACTIVE 3070 01:51:35,160 --> 01:51:35,680 COMPONENTS. 3071 01:51:35,680 --> 01:51:38,200 FINALLY, NOAA HAS WORKED WITH US 3072 01:51:38,200 --> 01:51:40,320 FOR COLLECTION OF MARINE 3073 01:51:40,320 --> 01:51:40,840 ORGANISMS FOR BIOMEDICAL 3074 01:51:40,840 --> 01:51:47,320 RESEARCH THAT COULD BE ADDED TO 3075 01:51:47,320 --> 01:51:48,520 THIS PROGRAM. 3076 01:51:48,520 --> 01:51:50,400 THE GOAL IS TO GET EVERYTHING 3077 01:51:50,400 --> 01:51:52,480 YOU ABOUT THE MAJORITY OF 3078 01:51:52,480 --> 01:51:54,200 RESEARCHERS DON'T HAVE THE 3079 01:51:54,200 --> 01:51:54,960 CHEMISTRY EXPERTISE PERHAPS IN 3080 01:51:54,960 --> 01:51:56,600 HOUSE TO HELP WITH THAT. 3081 01:51:56,600 --> 01:52:00,560 SO WE BUILT SYSTEMS THAT GET 3082 01:52:00,560 --> 01:52:02,160 HIGH-THROUGHPUT FAST TO HELP 3083 01:52:02,160 --> 01:52:05,360 RESEARCHERS WITH THAT SO CREATED 3084 01:52:05,360 --> 01:52:06,320 AUTOMATED SECOND STAGE 3085 01:52:06,320 --> 01:52:08,200 PURIFICATION SYSTEM TO HELP UP 3086 01:52:08,200 --> 01:52:10,280 TO 500 SAMPLES OF A HIT LIST 3087 01:52:10,280 --> 01:52:11,600 FROM SOMEBODY OF FRACTIONS 3088 01:52:11,600 --> 01:52:13,560 ACTIVE IN THEIR SCREENS, WE 3089 01:52:13,560 --> 01:52:16,400 COULD TAKE THOSE AND PURIFY THEM 3090 01:52:16,400 --> 01:52:19,920 INTO 22 SUBFRACTIONS FOR EACH 3091 01:52:19,920 --> 01:52:22,520 FRACTION, DRIP THOSE INTO 3092 01:52:22,520 --> 01:52:23,160 HIGH-THROUGHPUT SCREENING 3093 01:52:23,160 --> 01:52:24,840 PLATES, DRY AND SHIP OVER 10,000 3094 01:52:24,840 --> 01:52:27,480 FRACTIONS TO THOSE SCREENING 3095 01:52:27,480 --> 01:52:29,680 LABS WITHIN TWO WEEKS. 3096 01:52:29,680 --> 01:52:36,400 THIS GENERATES VALUABLE CHEMICAL 3097 01:52:36,400 --> 01:52:38,280 INFORMATION, NMR, MASS SPEC, 3098 01:52:38,280 --> 01:52:39,680 REDUCES COST BECAUSE NOW LABS 3099 01:52:39,680 --> 01:52:41,320 DON'T HAVE TO KEEP ASSAYS UP FOR 3100 01:52:41,320 --> 01:52:43,760 QUITE SUCH A LONG STRETCH OF 3101 01:52:43,760 --> 01:52:45,840 TIME, AND ALSO REDUCES COST OF 3102 01:52:45,840 --> 01:52:48,680 CHEMISTRY. 3103 01:52:48,680 --> 01:52:49,840 IMPORTANTLY CONSERVES EXTRACTS. 3104 01:52:49,840 --> 01:52:52,480 WE CAN GET SAME DATA FROM ONE 3105 01:52:52,480 --> 01:52:53,440 MILLIGRAM OF A FRACTION THAT 3106 01:52:53,440 --> 01:52:56,720 USED TO TAKE A GRAM OF EXTRACT. 3107 01:52:56,720 --> 01:53:00,560 AND SO THIS LIBRARY OF 200,000 3108 01:53:00,560 --> 01:53:02,080 EXTRACTS WILL BE PRESERVED FOR A 3109 01:53:02,080 --> 01:53:03,920 MUCH LONGER PERIOD OF TIME. 3110 01:53:03,920 --> 01:53:06,560 BRIEF DETAILS OF WHERE WE ARE SO 3111 01:53:06,560 --> 01:53:08,200 FAR, WE'VE DONE THIS WITH 3112 01:53:08,200 --> 01:53:09,840 SEVERAL PROJECTS, SEVERAL 3113 01:53:09,840 --> 01:53:13,440 GROUPS, BAYLOR, UNIVERSITY OF 3114 01:53:13,440 --> 01:53:16,600 TEXAS, WALTER REED, 65,000 3115 01:53:16,600 --> 01:53:18,200 PURIFIED SUBTRACTIONS, 70% OF 3116 01:53:18,200 --> 01:53:19,880 THE TIME FROM THESE SUBFRACTIONS 3117 01:53:19,880 --> 01:53:20,960 WE CAN DETERMINE THE COMPOUND 3118 01:53:20,960 --> 01:53:24,400 CLASS OF THE ACTIVE COMPONENT 3119 01:53:24,400 --> 01:53:29,240 WITH NO FURTHER PURIFICATION. 3120 01:53:29,240 --> 01:53:32,840 THIS REQUIRES SIGNIFICANTLY LESS 3121 01:53:32,840 --> 01:53:34,360 CHEMIST TIME, ONE TO TWO MONTHS. 3122 01:53:34,360 --> 01:53:35,760 80% OF THE TIME WE SEE ACTIVITY 3123 01:53:35,760 --> 01:53:38,480 IN ONE OF THESE FRACTIONS, WE DO 3124 01:53:38,480 --> 01:53:48,480 NOT SEE ACTIVITY FROM THE CRUDE 3125 01:53:48,480 --> 01:53:51,280 EXTRACT, UNCOVERING CHEMICAL 3126 01:53:51,280 --> 01:53:51,560 DIVERSITY. 3127 01:53:51,560 --> 01:53:54,040 THESE METHODS AND PROCEDURES AND 3128 01:53:54,040 --> 01:53:55,720 AUTOMATION WE USE WERE PUBLISHED 3129 01:53:55,720 --> 01:53:56,280 IN 2020. 3130 01:53:56,280 --> 01:53:58,400 AND ONE THING WE WANTED TO DO TO 3131 01:53:58,400 --> 01:53:59,800 CHECK WHAT CAME OUT OF THIS 3132 01:53:59,800 --> 01:54:01,680 PROCESS WAS TO LOOK ARE THESE 3133 01:54:01,680 --> 01:54:03,400 DRUG-LIKE MOLECULES AT THE END, 3134 01:54:03,400 --> 01:54:05,200 THINGS THAT COULD ACTUALLY BE 3135 01:54:05,200 --> 01:54:05,440 DEVELOPED? 3136 01:54:05,440 --> 01:54:06,440 AND SO WE COMPARED THE COMPOUNDS 3137 01:54:06,440 --> 01:54:11,120 THAT CAME OUT OF OUR PILOT 3138 01:54:11,120 --> 01:54:12,560 SCREEN BY PRINCIPAL COMPONENT 3139 01:54:12,560 --> 01:54:13,800 ANALYSIS, THREE COMPONENTS MAKE 3140 01:54:13,800 --> 01:54:20,400 UP THE MAJORITY OF DIFFERENTIAL 3141 01:54:20,400 --> 01:54:22,200 BETWEEN COMPOUNDS, MOLECULAR 3142 01:54:22,200 --> 01:54:27,000 WEIGHT, LIPO VOW LISTTY AND 3143 01:54:27,000 --> 01:54:29,000 COMPOUNDS. 3144 01:54:29,000 --> 01:54:31,720 LARGELY THEY OVERLAP BETWEEN 3145 01:54:31,720 --> 01:54:32,680 1981 AND 2010 INDICATING WE SEEM 3146 01:54:32,680 --> 01:54:34,880 TO BE IN AN AREA OF CHEMICAL 3147 01:54:34,880 --> 01:54:37,200 DIVERSITY THAT HAS PROVEN 3148 01:54:37,200 --> 01:54:42,800 SUCCESSFUL IN THE PAST TO 3149 01:54:42,800 --> 01:54:43,040 DEVELOP. 3150 01:54:43,040 --> 01:54:45,040 THERE'S A LOT OF DATA INVOLVED. 3151 01:54:45,040 --> 01:54:46,880 WE DEVELOPED A WEB ACCESSIBLE 3152 01:54:46,880 --> 01:54:48,160 AND SECURE SYSTEM TO TRACK 3153 01:54:48,160 --> 01:54:49,800 EVERYTHING FROM THE PRODUCTION 3154 01:54:49,800 --> 01:54:51,760 OF FRACTIONS TO PLATED SAMPLES 3155 01:54:51,760 --> 01:54:54,480 TO EACH INDIVIDUAL PROJECT WITH 3156 01:54:54,480 --> 01:54:56,080 EACH INDIVIDUAL MTA HOLDER. 3157 01:54:56,080 --> 01:55:01,080 AS WELL AS EVERY SOURCE ORGANISM 3158 01:55:01,080 --> 01:55:07,200 TO GPS COORDINATES, CHEMISTRY 3159 01:55:07,200 --> 01:55:07,640 AND BIOLOGY. 3160 01:55:07,640 --> 01:55:10,600 I'M GOING INTO DETAIL ON THREE 3161 01:55:10,600 --> 01:55:11,360 DIFFERENT OUTCOMES HERE TO 3162 01:55:11,360 --> 01:55:12,800 DETAIL NOW THAT WE HAVE THIS CAN 3163 01:55:12,800 --> 01:55:14,240 WE DO SOME THINGS MAYBE WE 3164 01:55:14,240 --> 01:55:22,240 COULDN'T DO BEFORE WITH NATURAL 3165 01:55:22,240 --> 01:55:22,520 PRODUCTS. 3166 01:55:22,520 --> 01:55:25,080 FIRST BIOPHYSICAL ASSAY, BETTER 3167 01:55:25,080 --> 01:55:27,040 BEHAVED THAN CRUDE EXTRACTS. 3168 01:55:27,040 --> 01:55:33,200 IN THIS CASE DIFFERENTIAL 3169 01:55:33,200 --> 01:55:34,360 SCANNING FLUOROMETRY. 3170 01:55:34,360 --> 01:55:37,360 WE ARE TAKING THIS OVER A 3171 01:55:37,360 --> 01:55:38,800 TEMPERATURE GRADIENT TO SEE IT'S 3172 01:55:38,800 --> 01:55:40,360 MELTING, ADD COMPOUNDS TO SEE IF 3173 01:55:40,360 --> 01:55:42,120 THEY CAN ALTER THAT MELTING 3174 01:55:42,120 --> 01:55:47,040 TEMPERATURE OF THAT microRNA 3175 01:55:47,040 --> 01:55:49,760 AND FRACTIONS, DETECTING 3176 01:55:49,760 --> 01:55:50,280 STABILIZATION AND 3177 01:55:50,280 --> 01:55:51,720 DESTABILIZATION, NEVER USED WITH 3178 01:55:51,720 --> 01:55:52,800 NATURAL PRODUCT EXTRACTS. 3179 01:55:52,800 --> 01:55:54,800 THIS IS NOW REDUCED TO PRACTICE 3180 01:55:54,800 --> 01:55:58,360 IN THE NCI AND WE CAN DO THIS 3181 01:55:58,360 --> 01:56:04,600 ASSAY IN SEVEN MICRO LITERS PER 3182 01:56:04,600 --> 01:56:04,920 WELL. 3183 01:56:04,920 --> 01:56:06,680 INITIAL RESULT, THIS COMPOUND 3184 01:56:06,680 --> 01:56:11,400 WAS ABLE TO MODIFY THE MELTING 3185 01:56:11,400 --> 01:56:12,960 TEMPERATURE PREMIER 21 BY 3.4 3186 01:56:12,960 --> 01:56:14,200 DEGREES CENTIGRADE, FROM THIS 3187 01:56:14,200 --> 01:56:16,120 MICRO YOU SEE HERE. 3188 01:56:16,120 --> 01:56:18,320 WHEN WE FURTHER STUDIED, WE SAW 3189 01:56:18,320 --> 01:56:19,200 THAT IT ACTUALLY INDUCED A 3190 01:56:19,200 --> 01:56:20,520 SECOND FORM THAT YOU SEE IN 3191 01:56:20,520 --> 01:56:23,200 PURPLE HERE IN THE MELTING 3192 01:56:23,200 --> 01:56:30,360 CURVE, HIGHER TEMPERATURE 3193 01:56:30,360 --> 01:56:32,200 MELTING FORM OF PRE-MIR-21, 3194 01:56:32,200 --> 01:56:36,120 SEEING A CUPPER COILED FORM OF 3195 01:56:36,120 --> 01:56:37,400 PRE-MIR-21 -- SUPERCOILED FORM 3196 01:56:37,400 --> 01:56:40,960 OF PRE-MIR-21, LESS SUITABLE FOR 3197 01:56:40,960 --> 01:56:50,920 RISK, ENDED UP RESULTING IN LESS 3198 01:56:50,920 --> 01:56:54,040 MIR-21 IN COLON CANCER CELLS. 3199 01:56:54,040 --> 01:57:00,600 WE SAW AN INCREASE, RELATIVE TO 3200 01:57:00,600 --> 01:57:08,200 MIR- 2 1 LEVELS. 3201 01:57:08,200 --> 01:57:10,720 THIS SHOWS NATURAL PRODUCTS CAN 3202 01:57:10,720 --> 01:57:12,720 APPROACH TAR GETS PEOPLE DIDN'T 3203 01:57:12,720 --> 01:57:14,240 THINK WERE APPROACHABLE FOR 3204 01:57:14,240 --> 01:57:15,800 NATURAL PRODUCTS WITH ASSAYS 3205 01:57:15,800 --> 01:57:17,200 THEY DIDN'T CONSIDER WOULD BE 3206 01:57:17,200 --> 01:57:18,800 AMENABLE TO NATURAL PRODUCTS 3207 01:57:18,800 --> 01:57:19,040 SCREENING. 3208 01:57:19,040 --> 01:57:21,920 HERE I'D LIKE TO MENTION WE CAN 3209 01:57:21,920 --> 01:57:22,800 FIND POTENTIAL BIOTHERAPEUTICS 3210 01:57:22,800 --> 01:57:24,200 FROM NATURAL PRODUCTS. 3211 01:57:24,200 --> 01:57:30,800 HERE THIS WAS AN ENZYMATIC ASSAY 3212 01:57:30,800 --> 01:57:36,080 LOOKING AT INHIBITION IMPORTANT 3213 01:57:36,080 --> 01:57:41,600 FOR RESISTANCE TO TOP1 3214 01:57:41,600 --> 01:57:45,320 INHIBITORS, AN ALLOSTERIC 3215 01:57:45,320 --> 01:57:46,520 INHIBITOR BOUND TO REGULATORY 3216 01:57:46,520 --> 01:57:49,440 DOMAIN OF THE PROTEIN, HAD A 3217 01:57:49,440 --> 01:57:52,400 UNIQUE STRUCTURE AND DEFINED A 3218 01:57:52,400 --> 01:57:56,000 WHOLE NEW CLASS OF PEPTIDES WITH 3219 01:57:56,000 --> 01:58:00,040 UNIQUE TYROSYL LOCK STRUCTURED 3220 01:58:00,040 --> 01:58:01,360 LOCKED IN THREE DIMENSIONAL 3221 01:58:01,360 --> 01:58:03,640 SPACE STABILIZING THE UNIT, NOW 3222 01:58:03,640 --> 01:58:05,040 PATENTED AND ALREADY IN ACTIVE 3223 01:58:05,040 --> 01:58:08,320 LICENSING BY THE NCI FOR 3224 01:58:08,320 --> 01:58:09,080 CLINICAL -- FOR THERAPEUTIC 3225 01:58:09,080 --> 01:58:10,320 DEVELOPMENT I SHOULD SAY. 3226 01:58:10,320 --> 01:58:13,000 FINALLY WE CAN USE THE DATA THAT 3227 01:58:13,000 --> 01:58:14,240 WE'RE DERIVING, IF WE LOOK AT 3228 01:58:14,240 --> 01:58:17,400 THE DATA FROM ALL THE NCI 60 3229 01:58:17,400 --> 01:58:19,720 DATA WITH EXTRACTS WE STARTED 3230 01:58:19,720 --> 01:58:20,440 DEVELOPING SELF-ORGANIZING MAP 3231 01:58:20,440 --> 01:58:21,680 TECHNOLOGIES TO LOOK AT THIS, 3232 01:58:21,680 --> 01:58:24,760 THIS ALLOWED US TO EVALUATE 3233 01:58:24,760 --> 01:58:27,480 ABOUT 1400 COMPOUNDS, PUBLISHED 3234 01:58:27,480 --> 01:58:31,200 ON THAT, IN MOLECULAR ONCOLOGY 3235 01:58:31,200 --> 01:58:32,640 AND APPENDED WITH DATA ON 3236 01:58:32,640 --> 01:58:34,280 SPECIFIC GENETIC SIGNATURE FOR 3237 01:58:34,280 --> 01:58:36,000 THE CELL LINES, MUTATIONS, 3238 01:58:36,000 --> 01:58:36,800 EXPRESSION LEVELS. 3239 01:58:36,800 --> 01:58:41,160 THIS ALLOWED US TO MOVE TO 3240 01:58:41,160 --> 01:58:44,160 140,000 RECORDS OF NATURAL 3241 01:58:44,160 --> 01:58:48,040 PRODUCT SAMPLES, DEFINE NEW 3242 01:58:48,040 --> 01:58:48,400 COMPOUNDS. 3243 01:58:48,400 --> 01:58:50,880 THIS FROM SOUTH AFRICA PRODUCED 3244 01:58:50,880 --> 01:58:56,600 A NEW CARBON SKELETON THAT 3245 01:58:56,600 --> 01:58:59,600 SELECTIVELY TARGETED 3246 01:58:59,600 --> 01:59:02,320 OVEREXPRESSING CELLS AND KILLED 3247 01:59:02,320 --> 01:59:02,520 THEM. 3248 01:59:02,520 --> 01:59:04,160 WITH THAT I'D LIKE TO THANK YOU, 3249 01:59:04,160 --> 01:59:07,080 I HOPE I'VE SHOWN SOME NEW 3250 01:59:07,080 --> 01:59:08,280 TECHNOLOGIES, METHODS, CHEMICAL 3251 01:59:08,280 --> 01:59:10,280 DIVERSITIES AND SOME 3252 01:59:10,280 --> 01:59:14,800 PARTNERSHIPS THAT THIS PROGRAM 3253 01:59:14,800 --> 01:59:18,000 HAS ENGENDERED AND BIOACTIVE 3254 01:59:18,000 --> 01:59:18,240 COMPOUNDS. 3255 01:59:18,240 --> 01:59:20,680 IN DISCUSSING WAYS TO BUILD, ONE 3256 01:59:20,680 --> 01:59:21,920 WAY I HEARD DR. SHARPLESS 3257 01:59:21,920 --> 01:59:24,440 DISCUSS THIS AT A PREVIOUS 3258 01:59:24,440 --> 01:59:25,200 MEETING, WITH THE SUBCOMMITTEE, 3259 01:59:25,200 --> 01:59:27,840 AND ONE OF THE THINGS WE HAVE 3260 01:59:27,840 --> 01:59:31,120 USED SUCCESSFULLY WITH NCATS AND 3261 01:59:31,120 --> 01:59:33,960 NCCIH, IGNITE PROGRAM TYPE OF 3262 01:59:33,960 --> 01:59:35,920 GRANTING, INNOVATION GRANTS TO 3263 01:59:35,920 --> 01:59:37,760 NURTURE TRANSLATIONAL EFFORTS 3264 01:59:37,760 --> 01:59:40,280 AND TWO-STEP FUNDING MECHANISM 3265 01:59:40,280 --> 01:59:41,560 THAT ENCOURAGES HTS ASSAY 3266 01:59:41,560 --> 01:59:42,360 DEVELOPMENT AND SCREENING AND 3267 01:59:42,360 --> 01:59:45,560 SHOULD THERE WISH TO BE BUILD 3268 01:59:45,560 --> 01:59:47,160 UPON THIS WITH MORE EXTRAMURAL 3269 01:59:47,160 --> 01:59:47,720 RESEARCHERS GETTING INVOLVED 3270 01:59:47,720 --> 01:59:50,160 WITH SCREENING THIS IS ONE 3271 01:59:50,160 --> 01:59:50,920 POTENTIAL AVENUE. 3272 01:59:50,920 --> 01:59:52,120 WITH THAT I'D LIKE TO THANK YOU 3273 01:59:52,120 --> 01:59:53,320 AGAIN FOR THE OPPORTUNITY TO 3274 01:59:53,320 --> 01:59:56,120 HEAR YOUR THOUGHTS AND ADVICE ON 3275 01:59:56,120 --> 01:59:56,320 THIS. 3276 01:59:56,320 --> 01:59:58,240 AND THANK ALL THE PEOPLE 3277 01:59:58,240 --> 02:00:00,160 INVOLVED WITH THE RESERVE. 3278 02:00:00,160 --> 02:00:02,400 >> THANKS, BARRY. 3279 02:00:02,400 --> 02:00:06,360 THAT WAS A FANTASTIC 3280 02:00:06,360 --> 02:00:06,680 PRESENTATION. 3281 02:00:06,680 --> 02:00:08,200 WE DO HAVE A FEW MINUTES, FOUR 3282 02:00:08,200 --> 02:00:09,600 MINUTES FOR QUESTIONS. 3283 02:00:09,600 --> 02:00:15,520 I SEE CHRIS' HAND UP. 3284 02:00:15,520 --> 02:00:16,560 >> DR. O'KEEFE, THANK YOU. 3285 02:00:16,560 --> 02:00:18,200 JOHN, THANK YOU FOR YOUR 3286 02:00:18,200 --> 02:00:18,520 PRESENTATION. 3287 02:00:18,520 --> 02:00:19,400 EXCITING WORK. 3288 02:00:19,400 --> 02:00:20,800 THANK YOU AND YOUR COLLEAGUES. 3289 02:00:20,800 --> 02:00:22,800 I QUESTION THAT HAD COME TO US 3290 02:00:22,800 --> 02:00:24,000 EARLIER A LITTLE BIT, 3291 02:00:24,000 --> 02:00:26,520 UNDERSTANDING WAS THIS MIGHT BE 3292 02:00:26,520 --> 02:00:28,440 SORT OF AN UNDERTAPPED RESOURCE 3293 02:00:28,440 --> 02:00:30,200 FOR THE COMMUNITY, AND WANTED TO 3294 02:00:30,200 --> 02:00:33,520 THINK ABOUT THAT WITH YOU. 3295 02:00:33,520 --> 02:00:35,560 SO THE QUESTION AND SUGGESTION 3296 02:00:35,560 --> 02:00:36,800 ARE HAVE YOU TAKEN THIS SLIDE 3297 02:00:36,800 --> 02:00:38,840 DECK ON THE ROAD? 3298 02:00:38,840 --> 02:00:40,280 IT'S EXTREMELY IMPRESSIVE. 3299 02:00:40,280 --> 02:00:41,720 I WOULD IMAGINE A BRIEF 3300 02:00:41,720 --> 02:00:43,160 PRESENTATION TO THE CANCER 3301 02:00:43,160 --> 02:00:46,560 CENTER DIRECTORS AND/OR THEIR 3302 02:00:46,560 --> 02:00:47,200 DEVELOPMENTAL THERAPEUTICS 3303 02:00:47,200 --> 02:00:49,720 PROGRAMS ACROSS CENTERS, I WANT 3304 02:00:49,720 --> 02:00:53,200 TO SHARE WITH MY D T PROGRAM. 3305 02:00:53,200 --> 02:00:55,000 THAT MIGHT HELP FACILITATE MORE 3306 02:00:55,000 --> 02:00:57,640 THE TWO-WAY INTERACTION AND EVEN 3307 02:00:57,640 --> 02:00:58,520 INCREASE THE ALREADY IMPRESSIVE 3308 02:00:58,520 --> 02:01:00,800 BODY OF WORK YOU AND YOUR TEAM 3309 02:01:00,800 --> 02:01:01,880 HAVE DONE. 3310 02:01:01,880 --> 02:01:03,440 SO THOUGHTS ON DISSEMINATION AND 3311 02:01:03,440 --> 02:01:06,000 OUTREACH TO THE NCI CENTERS, OR 3312 02:01:06,000 --> 02:01:06,960 OTHER INSTITUTES THAT MIGHT BE 3313 02:01:06,960 --> 02:01:08,240 HELPFUL TO YOU IN THIS WORK? 3314 02:01:08,240 --> 02:01:08,920 THANK YOU. 3315 02:01:08,920 --> 02:01:17,600 >> I MEAN, I WOULD BE HAPPY TO. 3316 02:01:17,600 --> 02:01:21,000 NED HAS INVITED ME TO SPEAK. 3317 02:01:21,000 --> 02:01:23,280 WITH COVID WE HAVEN'T HAD AS 3318 02:01:23,280 --> 02:01:23,840 MANY OPPORTUNITIES TO 3319 02:01:23,840 --> 02:01:26,200 DISSEMINATE OVER THE LAST COUPLE 3320 02:01:26,200 --> 02:01:26,400 YEARS. 3321 02:01:26,400 --> 02:01:27,400 BUT PEOPLE HAD BEEN SEEMING TO 3322 02:01:27,400 --> 02:01:28,560 FIND US. 3323 02:01:28,560 --> 02:01:32,600 MAYBE WE DIDN'T PUT AS MUCH 3324 02:01:32,600 --> 02:01:34,640 IMPETUS AS WE CAN. 3325 02:01:34,640 --> 02:01:36,440 VERY GOOD ADVICE AND WE'LL BE 3326 02:01:36,440 --> 02:01:38,200 HAPPY TO DO SO. 3327 02:01:38,200 --> 02:01:45,920 >> EXPANDING ON THAT, TRYING TO 3328 02:01:45,920 --> 02:01:47,560 TURN THIS SOMETHING MORE LAY THE 3329 02:01:47,560 --> 02:01:49,200 COMMUNITY WOULD LIKE TO HEAR AS 3330 02:01:49,200 --> 02:01:51,040 WELL, HOW NATURAL PRODUCTS ARE 3331 02:01:51,040 --> 02:01:53,200 BEING USED AND DEVELOPED FOR 3332 02:01:53,200 --> 02:01:54,440 BATTLING CANCER. 3333 02:01:54,440 --> 02:01:58,920 I SEE YOUR HAND, WE HAVE AMY AND 3334 02:01:58,920 --> 02:02:01,360 WE'LL GO TO YOU, FRANCIS. 3335 02:02:01,360 --> 02:02:03,960 >> SEGUEING ON WHAT CHRISTOPHER 3336 02:02:03,960 --> 02:02:07,640 COMMENTED ON, YOU'RE USING 3337 02:02:07,640 --> 02:02:09,000 NCI-60 AS A HIGH-THROUGHPUT 3338 02:02:09,000 --> 02:02:09,960 SCREEN IDENTIFYING COMPOUNDS 3339 02:02:09,960 --> 02:02:13,440 WITH DIRECT CANCER EFFECT BUT 3340 02:02:13,440 --> 02:02:14,120 THE OTHER AREA, INTERESTED TO 3341 02:02:14,120 --> 02:02:17,600 SEE IF YOU MADE COLLABORATIVE 3342 02:02:17,600 --> 02:02:22,240 EFFORTS IN THIS PARTICULAR 3343 02:02:22,240 --> 02:02:23,320 STRATEGY, HIGH-THROUGHPUT FOR 3344 02:02:23,320 --> 02:02:25,720 I-O, THERE'S IMMUNE CHECKPOINT 3345 02:02:25,720 --> 02:02:26,800 INHIBITORS, ET CETERA, A LOT OF 3346 02:02:26,800 --> 02:02:28,720 TIMES THESE THINGS DON'T 3347 02:02:28,720 --> 02:02:29,600 NECESSARILY REVERSE EXHAUSTION, 3348 02:02:29,600 --> 02:02:30,400 ET CETERA. 3349 02:02:30,400 --> 02:02:32,280 SO YOU COULD CERTAINLY ENVISION 3350 02:02:32,280 --> 02:02:33,720 UTILIZING THIS PANEL AND 3351 02:02:33,720 --> 02:02:34,960 IDENTIFYING SOME OF YOUR HIGH 3352 02:02:34,960 --> 02:02:38,120 CONTENDERS FOR THOSE THAT COULD 3353 02:02:38,120 --> 02:02:39,800 POTENTIALLY REVERSE IMMUNE 3354 02:02:39,800 --> 02:02:44,200 EXHAUSTION OR INCREASE DIRECT 3355 02:02:44,200 --> 02:02:45,880 TUMOR CYTOTOXIC ACTIVITY, ALSO 3356 02:02:45,880 --> 02:02:46,760 THROUGH HIGH-THROUGHPUT. 3357 02:02:46,760 --> 02:02:47,680 HAS ANYBODY THOUGHT ABOUT DOING 3358 02:02:47,680 --> 02:02:50,200 THOSE YET WITH YOU GUYS IN THESE 3359 02:02:50,200 --> 02:02:50,840 NATURAL PRODUCTS? 3360 02:02:50,840 --> 02:02:52,800 IT WOULD BE QUITE INTERESTING. 3361 02:02:52,800 --> 02:02:58,360 >> I MEAN, WE'RE VERY 3362 02:02:58,360 --> 02:03:00,440 INTERESTED, WE HAVE SOME 3363 02:03:00,440 --> 02:03:02,840 COLLABORATION, I THINK IT'S VERY 3364 02:03:02,840 --> 02:03:03,800 IMPORTANT. 3365 02:03:03,800 --> 02:03:05,880 MY CURRENT UNDERSTANDING OF THE 3366 02:03:05,880 --> 02:03:08,320 MOLECULAR TARGETS ASSOCIATED 3367 02:03:08,320 --> 02:03:10,160 WITH IMMUNOLOGIC ONCOLOGY 3368 02:03:10,160 --> 02:03:16,080 TARGETS, 70% ARE CYTO STOLIC, 3369 02:03:16,080 --> 02:03:17,840 THIS COULD MAKE A BIG 3370 02:03:17,840 --> 02:03:18,160 DIFFERENCE. 3371 02:03:18,160 --> 02:03:19,800 PART IS GETTING ASSAYS INTO A 3372 02:03:19,800 --> 02:03:20,760 HIGH-THROUGHPUT MODE. 3373 02:03:20,760 --> 02:03:23,600 SOME ASSAYS PEOPLE APPROACHED US 3374 02:03:23,600 --> 02:03:28,040 WITH ARE NOT REALLY AMENABLE TO 3375 02:03:28,040 --> 02:03:33,000 384 MUCH LESS 1596 SCREENING, 3376 02:03:33,000 --> 02:03:34,840 WE WOULD BE HAPPY TO WORK WITH 3377 02:03:34,840 --> 02:03:37,040 PEOPLE WHO COULD DO THAT, AN 3378 02:03:37,040 --> 02:03:41,560 UNTAPPED AREA THAT COULD BE 3379 02:03:41,560 --> 02:03:44,360 FULLY EXPLOITED. 3380 02:03:44,360 --> 02:03:47,600 >> I HAVE AN APC AND T C WITH 3381 02:03:47,600 --> 02:03:49,320 EFFECTOR RESPONSE, A CELL WITH 3382 02:03:49,320 --> 02:04:00,240 THAT TECHNOLOGY, TO GO THROUGH 3383 02:04:00,240 --> 02:04:01,960 ON A SINGLE CELL. 3384 02:04:01,960 --> 02:04:03,680 >> TO REDUCE COMPLEXITY OF THE 3385 02:04:03,680 --> 02:04:04,360 LIBRARY, ANOTHER OPPORTUNITY 3386 02:04:04,360 --> 02:04:05,000 WITH THE I-O. 3387 02:04:05,000 --> 02:04:07,000 I WANT TO MAKE SURE FRANCIS HAS 3388 02:04:07,000 --> 02:04:08,840 AN OPPORTUNITY TO ASK HIS 3389 02:04:08,840 --> 02:04:09,600 QUESTION. 3390 02:04:09,600 --> 02:04:14,200 >> THANK YOU VERY MUCH, JOHN. 3391 02:04:14,200 --> 02:04:15,720 WE TOUCHED ON ONE OF THE POINTS 3392 02:04:15,720 --> 02:04:21,200 I WAS GOING TO BRING UP, IMMUNE 3393 02:04:21,200 --> 02:04:21,840 MODULATORS, IMMUNE SYSTEM, 3394 02:04:21,840 --> 02:04:22,840 CHECKPOINT INHIBITORS. 3395 02:04:22,840 --> 02:04:25,720 I WOULD BE EXTREMELY SURPRISED 3396 02:04:25,720 --> 02:04:27,480 IF YOU DIDN'T FIND SOME 3397 02:04:27,480 --> 02:04:28,320 IMPORTANT PLANT PRODUCTS THAT 3398 02:04:28,320 --> 02:04:29,520 WOULD DO THAT. 3399 02:04:29,520 --> 02:04:33,760 BUT IT'S ANOTHER AREA THAT I 3400 02:04:33,760 --> 02:04:35,200 THINK PRESENTS WONDERFUL 3401 02:04:35,200 --> 02:04:37,680 OPPORTUNITY. 3402 02:04:37,680 --> 02:04:40,800 THE CASE OF PREVENTION. 3403 02:04:40,800 --> 02:04:42,440 AGAIN, HISTORY OF NATURAL 3404 02:04:42,440 --> 02:04:45,400 PRODUCTS HAVE BEEN TO LOOK FOR 3405 02:04:45,400 --> 02:04:49,200 KILLING OF TUMOR CELLS, BUT WITH 3406 02:04:49,200 --> 02:04:51,760 ADVANCES THAT HAVE BEEN MADE, 3407 02:04:51,760 --> 02:04:54,000 ADVANCING IN EARLY CANCER 3408 02:04:54,000 --> 02:04:56,520 DETECTION, TARGETS AND SO ON, I 3409 02:04:56,520 --> 02:04:58,800 THINK IN ADDITION TO IMMUNE 3410 02:04:58,800 --> 02:05:00,800 MODULATORS ANOTHER AREA THAT I 3411 02:05:00,800 --> 02:05:05,600 THINK WOULD BE VERY, VERY 3412 02:05:05,600 --> 02:05:08,640 REWARDING WOULD BE LOOKING FOR 3413 02:05:08,640 --> 02:05:10,280 PLANT AGENTS THAT CAN AFFECT 3414 02:05:10,280 --> 02:05:14,800 EARLY STAGES OF CANCER, IT MIGHT 3415 02:05:14,800 --> 02:05:16,320 BE ANTIOXIDANTS, THINGS LIKE 3416 02:05:16,320 --> 02:05:17,000 THAT. 3417 02:05:17,000 --> 02:05:19,480 SO THAT WOULD ALSO REQUIRE JUST 3418 02:05:19,480 --> 02:05:22,560 LIKE WITH THE IMMUNE MODULATORS 3419 02:05:22,560 --> 02:05:26,000 DEVELOPING NEW SYSTEMS. 3420 02:05:26,000 --> 02:05:27,680 SO THIS WOULD REQUIRE 3421 02:05:27,680 --> 02:05:28,480 CROSS-DISCIPLINARY 3422 02:05:28,480 --> 02:05:31,320 CROSS-EXPERTISE TYPE OF 3423 02:05:31,320 --> 02:05:32,000 INITIATIVE. 3424 02:05:32,000 --> 02:05:35,160 BUT I THINK THAT'S AN AREA IN 3425 02:05:35,160 --> 02:05:36,320 ADDITION TO CHEMOTHERAPEUTICS OR 3426 02:05:36,320 --> 02:05:39,400 CYTO TOXICS ALSO TO LOOK AT 3427 02:05:39,400 --> 02:05:42,400 EARLY CANCER PREVENTION TYPE 3428 02:05:42,400 --> 02:05:42,600 AGENTS. 3429 02:05:42,600 --> 02:05:43,960 >> TOWARDS THAT END, A COUPLE 3430 02:05:43,960 --> 02:05:45,520 THINGS WE'VE DONE, I WAS AT THE 3431 02:05:45,520 --> 02:05:47,200 DIRECTOR OF THE DIVISION OF 3432 02:05:47,200 --> 02:05:49,040 CANCER PREVENTION ASKED ME TO 3433 02:05:49,040 --> 02:05:51,400 PRESENT TO HIS GROUP ABOUT THIS 3434 02:05:51,400 --> 02:05:51,800 INITIATIVE. 3435 02:05:51,800 --> 02:05:52,560 AND I DID. 3436 02:05:52,560 --> 02:05:55,520 AND THEY ARE INTERESTED IN 3437 02:05:55,520 --> 02:05:57,240 ACTUALLY FUNDING POTENTIAL 3438 02:05:57,240 --> 02:05:57,840 PEOPLE THROUGH THEIR 3439 02:05:57,840 --> 02:05:58,760 ORGANIZATION TO DEVELOP ASSAYS 3440 02:05:58,760 --> 02:06:01,360 THAT COULD BE USED WITH THIS 3441 02:06:01,360 --> 02:06:01,840 LIBRARY. 3442 02:06:01,840 --> 02:06:03,320 IN ADDITION IN THINKING MORE 3443 02:06:03,320 --> 02:06:04,960 ABOUT CANCER PREVENTION BECAUSE 3444 02:06:04,960 --> 02:06:05,960 THIS IS SOMETHING THAT DR. 3445 02:06:05,960 --> 02:06:08,560 SHARPLESS HAS STRESSED AS WELL 3446 02:06:08,560 --> 02:06:11,800 AS DR. MASTELLI IN THE CCR WHAT 3447 02:06:11,800 --> 02:06:16,480 WE'RE DOING THIS YEAR IS 3448 02:06:16,480 --> 02:06:17,880 CONCENTRATING ON PRE-FRACTIONATE 3449 02:06:17,880 --> 02:06:19,800 AQUEOUS EXTRACTS, SINCE THEY ARE 3450 02:06:19,800 --> 02:06:21,800 NORMALLY WHAT ARE USED FOR 3451 02:06:21,800 --> 02:06:23,160 TRADITIONAL HEALING AND SO WE 3452 02:06:23,160 --> 02:06:26,360 ARE GOING TO MAKE A LIBRARY OF 3453 02:06:26,360 --> 02:06:29,400 THINGS THAT ARE ON THE MEDICINAL 3454 02:06:29,400 --> 02:06:30,600 PLANTS AND GENERALLY REGARDED AS 3455 02:06:30,600 --> 02:06:32,200 SAFE LIST, THINGS LIKE THAT, 3456 02:06:32,200 --> 02:06:32,400 FOODS. 3457 02:06:32,400 --> 02:06:38,200 SO WE CAN HAVE THAT AS A 3458 02:06:38,200 --> 02:06:39,560 PRE-FRACTIONATED LIBRARY MORE 3459 02:06:39,560 --> 02:06:43,400 GERMANE TO CHEMOPREVENTION END 3460 02:06:43,400 --> 02:06:44,360 POINTS. 3461 02:06:44,360 --> 02:06:44,800 >> THANKS, BARRY. 3462 02:06:44,800 --> 02:06:46,280 BLOOD-BRAIN BARRIER IS ANOTHER 3463 02:06:46,280 --> 02:06:46,480 AREA. 3464 02:06:46,480 --> 02:06:47,680 IT'S TIME TO MOVE ON. 3465 02:06:47,680 --> 02:06:48,840 THANK YOU AGAIN. 3466 02:06:48,840 --> 02:06:50,640 TO MOVE TO OUR BREAK SO WE CAN 3467 02:06:50,640 --> 02:06:55,360 MOVE INTO OUR ADMINISTRATIVE 3468 02:06:55,360 --> 02:06:55,600 SESSION. 3469 02:06:55,600 --> 02:06:56,400 SO PAULETTE? 3470 02:06:56,400 --> 02:07:01,360 DO WE JUST BREAK? 3471 02:07:01,360 --> 02:07:02,680 WE WILL RECONVENE. 3472 02:07:02,680 --> 02:07:06,200 >> WE WILL RECONVENE AT 3473 02:07:06,200 --> 02:07:10,280 APPROXIMATELY -- LET'S SAY 3:30. 3474 02:07:10,280 --> 02:07:13,160 >> SO THE BOARD WILL NOW 3475 02:07:13,160 --> 02:07:15,760 CONSIDER ONGOING AND NEW 3476 02:07:15,760 --> 02:07:16,280 BUSINESS. 3477 02:07:16,280 --> 02:07:18,960 AMONG WHICH IS A PRESENTATION OF 3478 02:07:18,960 --> 02:07:20,560 ONE OF THE SUBCOMMITTEES. 3479 02:07:20,560 --> 02:07:23,280 THERE WAS A MEETING HELD TODAY, 3480 02:07:23,280 --> 02:07:24,880 THE CHAIR WILL PROVIDE THE 3481 02:07:24,880 --> 02:07:26,440 REPORT. 3482 02:07:26,440 --> 02:07:29,480 AND THAT WILL BE DR. FRANCIS 3483 02:07:29,480 --> 02:07:34,200 ALI-OSMAN, CHAIR OF THED AD HOC 3484 02:07:34,200 --> 02:07:36,560 SUBCOMMITTEE ON GLOBAL CANCER 3485 02:07:36,560 --> 02:07:38,760 RESEARCH. 3486 02:07:38,760 --> 02:07:39,240 FRANCIS? 3487 02:07:39,240 --> 02:07:42,600 >> THANK YOU, JOHN. 3488 02:07:42,600 --> 02:07:45,360 WE MET, THE SUBCOMMITTEE ON 3489 02:07:45,360 --> 02:07:46,440 GLOBAL CANCER RESEARCH MET A FEW 3490 02:07:46,440 --> 02:07:47,320 HOURS AGO. 3491 02:07:47,320 --> 02:07:49,640 I HAVEN'T HAD TOO MUCH TIME IN 3492 02:07:49,640 --> 02:07:53,160 BETWEEN THAT, IN THE MEETING, TO 3493 02:07:53,160 --> 02:07:54,520 GIVE A COMPREHENSIVE REPORT. 3494 02:07:54,520 --> 02:07:57,160 THIS WOULD BE A DRAFT REPORT. 3495 02:07:57,160 --> 02:08:00,640 WE'LL BE WORKING ON THE FINAL 3496 02:08:00,640 --> 02:08:06,160 REPORT WHICH WOULD BE 3497 02:08:06,160 --> 02:08:06,480 DISTRIBUTED. 3498 02:08:06,480 --> 02:08:07,520 SO, PUTTING TOGETHER MIGHT BE 3499 02:08:07,520 --> 02:08:11,640 GOING BACK AND FORTH A LITTLE 3500 02:08:11,640 --> 02:08:11,880 BIT. 3501 02:08:11,880 --> 02:08:14,480 IT WAS A VERY GOOD MEETING, ONE 3502 02:08:14,480 --> 02:08:15,800 HOUR LONG. 3503 02:08:15,800 --> 02:08:19,960 AND IT BEGAN WITH WELCOMING THE 3504 02:08:19,960 --> 02:08:22,960 NEW MEMBERS FOR THE COMMITTEE, 3505 02:08:22,960 --> 02:08:26,320 REMINDING THE SUBCOMMITTEE OF 3506 02:08:26,320 --> 02:08:27,600 THE CHARGE. 3507 02:08:27,600 --> 02:08:30,320 THE DIRECTOR OF THE CENTER, 3508 02:08:30,320 --> 02:08:34,560 PRESENTED A BRIEF UPDATE ON THE 3509 02:08:34,560 --> 02:08:35,440 CENTER. 3510 02:08:35,440 --> 02:08:38,360 STRATEGIC GOAL OF PLAN OF THE 3511 02:08:38,360 --> 02:08:42,240 CGH, REALLY IN THE CONTEXT OF 3512 02:08:42,240 --> 02:08:45,760 THE WORLD CANCER DAY WHICH HAD A 3513 02:08:45,760 --> 02:08:47,440 TEAM TO CLOSE THE CARE GAP IN 3514 02:08:47,440 --> 02:08:53,200 THE WORLD WITH RESPECT TO 3515 02:08:53,200 --> 02:08:55,320 CANCER. 3516 02:08:55,320 --> 02:08:58,040 WITH PRESIDENT BIDEN LAUNCHING 3517 02:08:58,040 --> 02:08:59,560 THE CANCER MOONSHOT AND 3518 02:08:59,560 --> 02:09:04,960 COMMITMENT TO GLOBAL HEALTH, THE 3519 02:09:04,960 --> 02:09:12,640 FOCUS IS ON LMIC, WITH RESEARCH, 3520 02:09:12,640 --> 02:09:14,600 RESEARCH PARTNERSHIP, THE GOAL 3521 02:09:14,600 --> 02:09:17,960 TO SUPPORT RESEARCH THAT 3522 02:09:17,960 --> 02:09:21,280 ADDRESSES GLOBAL CANCER CONTROL. 3523 02:09:21,280 --> 02:09:22,800 IN TRAINING, SUPPORT TRAINING 3524 02:09:22,800 --> 02:09:26,240 THAT ENABLE ALSO EQUITABLE AND 3525 02:09:26,240 --> 02:09:27,640 IMPACTFUL GLOBAL CANCER 3526 02:09:27,640 --> 02:09:28,120 COLLABORATIONS. 3527 02:09:28,120 --> 02:09:31,080 AND ALSO WITH BUILDING OF 3528 02:09:31,080 --> 02:09:32,840 CAPACITY IN THESE COUNTRIES. 3529 02:09:32,840 --> 02:09:34,600 IT'S CRITICAL, ONE OF THE 3530 02:09:34,600 --> 02:09:36,120 PILLARS, PROMOTING INTEGRATION 3531 02:09:36,120 --> 02:09:37,160 OF CURRENT SCIENTIFIC KNOWLEDGE 3532 02:09:37,160 --> 02:09:39,960 INTO GLOBAL CANCER RESEARCH 3533 02:09:39,960 --> 02:09:43,120 POLICIES AND CREATE PARTNERSHIPS 3534 02:09:43,120 --> 02:09:45,440 AND PROMOTING ENGAGEMENT WITH 3535 02:09:45,440 --> 02:09:51,920 KEY GLOBAL PARTNERS. 3536 02:09:51,920 --> 02:09:54,640 IT WAS PRESENTED TO US SOME OF 3537 02:09:54,640 --> 02:09:57,320 THE UPCOMING EVENTS AND PROGRAMS 3538 02:09:57,320 --> 02:10:01,080 AT THE CGH, A NUMBER OF THESE 3539 02:10:01,080 --> 02:10:03,160 INCLUDE U01, U 51 GLOBAL 3540 02:10:03,160 --> 02:10:05,960 IMPLEMENTATION SCIENCE PROGRAM, 3541 02:10:05,960 --> 02:10:09,680 AT LAST MEETING WE HAD -- I 3542 02:10:09,680 --> 02:10:12,080 THINK I PRESENTED INITIATIVES, 3543 02:10:12,080 --> 02:10:13,320 HIRING OF DR. KRAVITZ, AN EXPERT 3544 02:10:13,320 --> 02:10:15,840 IN THAT. 3545 02:10:15,840 --> 02:10:24,200 THAT WAS AN EXPANSION OF THE D 3546 02:10:24,200 --> 02:10:26,960 43 CANCER TRAINING PROGRAM, AND 3547 02:10:26,960 --> 02:10:29,600 SURVEY OF DESIGNATED CANCER 3548 02:10:29,600 --> 02:10:32,320 CENTERS, NCI DESIGNATED CANCER 3549 02:10:32,320 --> 02:10:32,920 CENTERS, IMPORTANT DISCUSSION 3550 02:10:32,920 --> 02:10:35,040 BECAUSE A LOT OF GLOBAL CANCER 3551 02:10:35,040 --> 02:10:36,920 RESEARCH WERE GOING ON AT 3552 02:10:36,920 --> 02:10:39,680 VARIOUS CANCER CENTERS, THIS HAS 3553 02:10:39,680 --> 02:10:40,600 NEVER BEEN COORDINATED AND 3554 02:10:40,600 --> 02:10:41,520 LEVERAGE THE BY THE NCI, SO THIS 3555 02:10:41,520 --> 02:10:43,160 IS ONE OF THE MAJOR AREAS THAT 3556 02:10:43,160 --> 02:10:45,960 WE'LL HEAR MORE ABOUT IT IN 3557 02:10:45,960 --> 02:10:49,760 FUTURE REPORTS ON THE CGH. 3558 02:10:49,760 --> 02:10:58,480 THEN REPORTED ABOUT THAT ANNUAL 3559 02:10:58,480 --> 02:11:02,960 SYMPOSIUM ON THE 10th, 3560 02:11:02,960 --> 02:11:03,760 ORGANIZED 3561 02:11:03,760 --> 02:11:06,320 THE SUBCOMMITTEE ENCOURAGED THAT 3562 02:11:06,320 --> 02:11:08,360 COLLABORATION ACROSS WITH OTHER 3563 02:11:08,360 --> 02:11:12,760 STAKEHOLDERS IN THE CANCER 3564 02:11:12,760 --> 02:11:13,960 RESEARCH ENTERPRISE. 3565 02:11:13,960 --> 02:11:16,320 CONTINUING IN 202 WITH GLOBAL 3566 02:11:16,320 --> 02:11:19,440 CANCER RESEARCH AND CONTROL 3567 02:11:19,440 --> 02:11:21,200 SEMINAL SERIES. 3568 02:11:21,200 --> 02:11:24,640 SO, THE MAIN FOCUS OF THE ONE 3569 02:11:24,640 --> 02:11:30,800 HOUR WE HAD WAS ON ONE OF THE 3570 02:11:30,800 --> 02:11:35,040 MAJOR PROGRAMS OF THE NCI AND 3571 02:11:35,040 --> 02:11:38,480 THAT'S BEEN CHANNELED THROUGH 3572 02:11:38,480 --> 02:11:41,960 THE CGH. 3573 02:11:41,960 --> 02:11:46,960 AND THAT IS THE AFFORDABLE 3574 02:11:46,960 --> 02:11:48,640 TECHNOLOGIES PROGRAM. 3575 02:11:48,640 --> 02:11:49,440 ACT. 3576 02:11:49,440 --> 02:11:51,440 THIS IS A TRANSDIVISIONAL 3577 02:11:51,440 --> 02:11:53,640 PROGRAM MANAGED BY MULTIPLE 3578 02:11:53,640 --> 02:11:55,120 DIVISIONS, CENTER FOR GLOBAL 3579 02:11:55,120 --> 02:11:57,000 HEALTH, DIVISION OF CANCER 3580 02:11:57,000 --> 02:11:58,480 CONTROL AND POPULATION SCIENCES, 3581 02:11:58,480 --> 02:11:59,400 DIVISION OF CANCER PREVENTION, 3582 02:11:59,400 --> 02:12:04,560 DIVISION OF CANCER TREATMENT AND 3583 02:12:04,560 --> 02:12:11,600 DIAGNOSIS, AND THIS IS A TRULY 3584 02:12:11,600 --> 02:12:14,120 EXCITING PROGRAM. 3585 02:12:14,120 --> 02:12:17,080 DR. PEARLMAN WHO OVERSEES THAT 3586 02:12:17,080 --> 02:12:19,360 PROGRAM, PROVIDED OVERVIEW OF 3587 02:12:19,360 --> 02:12:24,560 THE ACT PROGRAM. 3588 02:12:24,560 --> 02:12:26,160 AND GAVE US SENSE OF WHAT THEY 3589 02:12:26,160 --> 02:12:28,800 HAVE BEEN ABLE TO ACCOMPLISH TO 3590 02:12:28,800 --> 02:12:29,440 DATE. 3591 02:12:29,440 --> 02:12:32,160 TO DATE THEY HAVE SUPPORTED 3592 02:12:32,160 --> 02:12:34,480 THREE FUNDING OPPORTUNITIES 3593 02:12:34,480 --> 02:12:36,280 THROUGH ANNOUNCEMENT FOAs, 3594 02:12:36,280 --> 02:12:40,040 COMPRISED OF SEVEN AWARDS, HALF 3595 02:12:40,040 --> 02:12:40,720 OF THESE FUNDED PROJECTS 3596 02:12:40,720 --> 02:12:42,320 INVOLVED IN VITRO ASSAYS, A BIT 3597 02:12:42,320 --> 02:12:47,680 OF DISCUSSION WHAT IN VITRO 3598 02:12:47,680 --> 02:12:50,760 ASSAYS WERE BUT ACTUALLY FOR US 3599 02:12:50,760 --> 02:12:53,280 DIAGNOSTIC IN NATURE, COLORECTAL 3600 02:12:53,280 --> 02:12:56,480 CANCER, CERVICAL, HPV AND SO ON. 3601 02:12:56,480 --> 02:12:59,840 AND THEN THEY HAD SEVERAL 3602 02:12:59,840 --> 02:13:03,440 PROJECTS, CANCER TREATMENT, AND 3603 02:13:03,440 --> 02:13:06,920 ON PORTABLE IMAGING. 3604 02:13:06,920 --> 02:13:08,680 AND THE IN-COUNTRY EXPERIENCES 3605 02:13:08,680 --> 02:13:11,360 THEY HAVE HAD LED TO NEW 3606 02:13:11,360 --> 02:13:16,040 DEVICES, BETTER SUITED TO LOCAL 3607 02:13:16,040 --> 02:13:16,600 ENVIRONMENT. 3608 02:13:16,600 --> 02:13:17,960 AND SOME OF THE A.C.T. 3609 02:13:17,960 --> 02:13:20,280 TECHNOLOGIES HAVE BEEN EXPANDED 3610 02:13:20,280 --> 02:13:22,880 TO OTHER TARGETS. 3611 02:13:22,880 --> 02:13:26,120 AND THERE WAS DISCUSSION ABOUT 3612 02:13:26,120 --> 02:13:28,560 HOW EFFECTIVE THE PROGRAM HAS 3613 02:13:28,560 --> 02:13:33,000 BEEN IN TRANSLATING SOME 3614 02:13:33,000 --> 02:13:35,440 TECHNOLOGIES DEVELOPED IN THE 3615 02:13:35,440 --> 02:13:39,560 A.C.T., AND IN THIS THEY WORK IN 3616 02:13:39,560 --> 02:13:40,920 PART WITH SBIR PROGRAM, WHICH OF 3617 02:13:40,920 --> 02:13:41,680 COURSE IS LIMITED. 3618 02:13:41,680 --> 02:13:44,960 THEY ALSO HAVE THE CAPACITY, 3619 02:13:44,960 --> 02:13:46,720 WORK DIRECTLY WITH THE INDUSTRY 3620 02:13:46,720 --> 02:13:50,120 PARTNERS THAT ARE INVOLVED IN 3621 02:13:50,120 --> 02:13:53,280 SOME OF THESE GRANTS THAT HAVE 3622 02:13:53,280 --> 02:13:54,480 BEEN AWARDED. 3623 02:13:54,480 --> 02:13:58,760 THEN WE HAD THE UNIQUE PLEASURE 3624 02:13:58,760 --> 02:14:05,600 TO HEAR FROM A NUMBER OF 3625 02:14:05,600 --> 02:14:08,760 INDIVIDUALS, ONE WAS THE TITLE 3626 02:14:08,760 --> 02:14:13,840 IS PROBABLY -- DR. AGRI SAMIR 3627 02:14:13,840 --> 02:14:19,280 FROM -- I THINK INFECTIOUS 3628 02:14:19,280 --> 02:14:22,840 DISEASE EXPERT. 3629 02:14:22,840 --> 02:14:35,400 AND HE ALSO TREATS KARPOSI 3630 02:14:35,400 --> 02:14:44,880 SARCOMA, THE PROBLEM IS IN 3631 02:14:44,880 --> 02:14:45,920 ADVANCED COUNTRIES THROUGH 3632 02:14:45,920 --> 02:14:47,240 BIOPSIES BUT IN LIMITED 3633 02:14:47,240 --> 02:14:52,760 RESOURCES, DIAGNOSIS IS MADE BY 3634 02:14:52,760 --> 02:14:55,160 CLINICAL OBSERVATION. 3635 02:14:55,160 --> 02:14:58,920 WORKING IN COLLABORATION WITH IN 3636 02:14:58,920 --> 02:15:05,560 THE UNITED STATES THEY DEVELOPED 3637 02:15:05,560 --> 02:15:07,160 TECHNIQUE, AN INSTRUMENT, TO 3638 02:15:07,160 --> 02:15:13,960 TAKE PUNCH BIOPSIES, AND THIS IS 3639 02:15:13,960 --> 02:15:17,080 A PCR-BASED INSTRUMENT THAT 3640 02:15:17,080 --> 02:15:19,080 WOULD EXTRACT NUCLEIC ACID, DNA 3641 02:15:19,080 --> 02:15:20,760 FROM THE PUNCH BIOPSY, ACTUALLY 3642 02:15:20,760 --> 02:15:26,000 GIVE A READOUT OF THE AMOUNT OF 3643 02:15:26,000 --> 02:15:30,160 VIRUS THAT IS IN THE SAMPLE. 3644 02:15:30,160 --> 02:15:33,840 AND VERY -- I THINK ANALYSIS ARE 3645 02:15:33,840 --> 02:15:43,280 THEN BEING DONE HERE IN THE 3646 02:15:43,280 --> 02:15:44,360 UNITED STATES. 3647 02:15:44,360 --> 02:15:46,360 I APOLOGIZE TO PULL THIS ALL 3648 02:15:46,360 --> 02:15:49,160 TOGETHER VERY QUICKLY. 3649 02:15:49,160 --> 02:15:50,920 3650 02:15:50,920 --> 02:15:52,600 BUT ANYWAY, THEY HAVE NOW -- 3651 02:15:52,600 --> 02:15:55,920 THEY ARE READY TO GO TO THE NEXT 3652 02:15:55,920 --> 02:16:05,440 STAGE, AND TEST THIS OUT ON THE 3653 02:16:05,440 --> 02:16:10,920 LARGER SCALE. 3654 02:16:10,920 --> 02:16:12,680 AND THE -- THERE WE GO. 3655 02:16:12,680 --> 02:16:19,560 THEY HAVE IN THREE COUNTRIES 3656 02:16:19,560 --> 02:16:21,760 WORKING WITH KENYA AND UGANDA 3657 02:16:21,760 --> 02:16:23,160 AND I THINK ZIMBABWE, THE 3658 02:16:23,160 --> 02:16:25,760 COLLABORATION THEY HAVE IS WITH 3659 02:16:25,760 --> 02:16:27,400 CORNELL UNIVERSITY. 3660 02:16:27,400 --> 02:16:30,400 AND DR. ERICKSON, WHO WAS ALSO 3661 02:16:30,400 --> 02:16:32,360 PRESENT AT THE PRESENTATION. 3662 02:16:32,360 --> 02:16:34,200 AND ADDRESSED SOME OF THE 3663 02:16:34,200 --> 02:16:38,480 QUESTIONS WE HAD. 3664 02:16:38,480 --> 02:16:43,440 THE NEXT ONE WAS RADIATION 3665 02:16:43,440 --> 02:16:45,160 THERAPY PLANNING IN LOW- AND 3666 02:16:45,160 --> 02:16:46,400 MIDDLE-INCOME COUNTRIES. 3667 02:16:46,400 --> 02:16:48,400 RADIATION THERAPY, MAIN STAY OF 3668 02:16:48,400 --> 02:16:50,480 CANCER THERAPY AT LEAST TODAY 3669 02:16:50,480 --> 02:16:52,880 REQUIRES SO MUCH EXPERTISE AND 3670 02:16:52,880 --> 02:16:55,760 HARD WORK TO CARRY OUT. 3671 02:16:55,760 --> 02:17:00,440 AND VERY FEW COUNTRIES IN AFRICA 3672 02:17:00,440 --> 02:17:01,960 OTHER THAN SOME SOUTH AFRICA A 3673 02:17:01,960 --> 02:17:03,960 FEW COUNTRIES IN NORTH AFRICA 3674 02:17:03,960 --> 02:17:08,480 ARE EQUIPPED TO DO IT. 3675 02:17:08,480 --> 02:17:10,760 THEY HAVE DEVELOPED THIS -- WHAT 3676 02:17:10,760 --> 02:17:13,280 THEY CALL THE RADIATION PLANNING 3677 02:17:13,280 --> 02:17:14,800 ASSISTANT TO FACILITATE AND TAKE 3678 02:17:14,800 --> 02:17:18,640 AWAY MOST OF THE TASKS THAT CAN 3679 02:17:18,640 --> 02:17:22,960 BE DONE WITHOUT HAVING HUMAN 3680 02:17:22,960 --> 02:17:23,800 EXPERTISE INVOLVED. 3681 02:17:23,800 --> 02:17:27,760 THEY BROUGHT THIS TO THE STAGE 3682 02:17:27,760 --> 02:17:29,160 THEY ARE READY TO TEST IN THE 3683 02:17:29,160 --> 02:17:31,880 FIELD IN SOUTH AFRICA AS WELL AS 3684 02:17:31,880 --> 02:17:33,560 OTHER AFRICAN COUNTRIES. 3685 02:17:33,560 --> 02:17:34,880 AND ARE WAITING FOR FDA APPROVAL 3686 02:17:34,880 --> 02:17:37,560 IN THE U.S. TO BE ABLE TO TAKE 3687 02:17:37,560 --> 02:17:45,120 TO THE NEXT STAGE. 3688 02:17:45,120 --> 02:17:48,960 SO, THIS A.C.T. PROGRAM HAS BEEN 3689 02:17:48,960 --> 02:17:50,400 SUCCESSFUL AND PRODUCTIVE, AND 3690 02:17:50,400 --> 02:17:51,880 THEY HAVE A DIRECTED -- I WOULD 3691 02:17:51,880 --> 02:17:53,560 RECOMMEND TO OTHER MEMBERS OF 3692 02:17:53,560 --> 02:17:57,000 THE BOARD TO GO TO THE CGH 3693 02:17:57,000 --> 02:17:58,200 WEBSITE WHERE THEY HAVE THE LIST 3694 02:17:58,200 --> 02:17:59,400 OF OTHER PROJECTS THEY HAVE 3695 02:17:59,400 --> 02:18:04,160 FUNDED AND WHERE THEY ARE TODAY. 3696 02:18:04,160 --> 02:18:06,800 IT WAS ONE PROJECT THAT WAS 3697 02:18:06,800 --> 02:18:11,960 EXCITING, WHICH WAS TO USE GEL 3698 02:18:11,960 --> 02:18:19,760 FOAM IMPREGNATED WITH ETHANOL TO 3699 02:18:19,760 --> 02:18:22,040 TREAT DYSPLASIA, CERVICAL 3700 02:18:22,040 --> 02:18:22,320 DYSPLASIA. 3701 02:18:22,320 --> 02:18:24,640 INSTEADING OF CUTTING IT OUT AND 3702 02:18:24,640 --> 02:18:25,960 THINGS THAT REQUIRE MORE 3703 02:18:25,960 --> 02:18:27,520 EXPERTISE AND INSTRUMENTATION. 3704 02:18:27,520 --> 02:18:30,400 THEY JUST INJECT THIS GEL FOAM, 3705 02:18:30,400 --> 02:18:49,160 THIS ALCOHOL IMPREGNATION, TO 3706 02:18:49,160 --> 02:18:49,960 KILL. 3707 02:18:49,960 --> 02:18:51,960 MAY BE POSSIBLE TO DISSEMINATE 3708 02:18:51,960 --> 02:18:53,760 IN OTHER RURAL AREAS OF THE 3709 02:18:53,760 --> 02:18:56,360 UNITED STATES WHERE CARE IS 3710 02:18:56,360 --> 02:18:57,160 SOMEWHAT LIMITED. 3711 02:18:57,160 --> 02:19:00,320 IN ONE HOUR, THIS IS ABOUT WHAT 3712 02:19:00,320 --> 02:19:04,000 WE'RE ABLE TO ACCOMPLISH. 3713 02:19:04,000 --> 02:19:07,960 BUT I THINK WE AGREE AT THE NEXT 3714 02:19:07,960 --> 02:19:10,000 MEETING WE'LL HAVE THE MORE 3715 02:19:10,000 --> 02:19:17,040 DETAILED UPDATE OF THE OTHER 3716 02:19:17,040 --> 02:19:18,560 PROGRAMS IN THE CGH. 3717 02:19:18,560 --> 02:19:22,560 WITH THAT I WILL STOP AND TAKE 3718 02:19:22,560 --> 02:19:25,840 ANY QUESTIONS. 3719 02:19:25,840 --> 02:19:26,480 >> THANK YOU. 3720 02:19:26,480 --> 02:19:27,920 PAULETTE, DO WE HAVE TIME FOR 3721 02:19:27,920 --> 02:19:28,160 QUESTIONS? 3722 02:19:28,160 --> 02:19:30,760 WE MAY HAVE TIME FOR ONE 3723 02:19:30,760 --> 02:19:33,720 QUESTION IF THERE'S ANYTHING. 3724 02:19:33,720 --> 02:19:34,840 >> OTHER MEMBERS OF THE 3725 02:19:34,840 --> 02:19:36,480 SUBCOMMITTEE CAN, YOU KNOW, CHIP 3726 02:19:36,480 --> 02:19:39,360 IN AND ADD IF I LEFT A FEW 3727 02:19:39,360 --> 02:19:39,840 THINGS OUT. 3728 02:19:39,840 --> 02:19:46,760 >> I HAVE A QUICK QUESTION. 3729 02:19:46,760 --> 02:19:48,160 FRANCIS, HOW READY FOR USE IN 3730 02:19:48,160 --> 02:19:51,880 THE UNITED STATES IS THE 3731 02:19:51,880 --> 02:19:54,160 MICROBIOPSY THAT PRINTS OUT THE 3732 02:19:54,160 --> 02:19:55,560 DNA, IS THAT SOMETHING THAT 3733 02:19:55,560 --> 02:19:59,040 THERE'S A REMOTE PERSON READING 3734 02:19:59,040 --> 02:20:01,280 THAT, THAT CAN BE SORT OF 3735 02:20:01,280 --> 02:20:01,840 QUICKLY APPLIED? 3736 02:20:01,840 --> 02:20:03,480 OR IS THAT SOMETHING ON THE 3737 02:20:03,480 --> 02:20:05,280 LONG-TERM HORIZON, YOU KNOW, A 3738 02:20:05,280 --> 02:20:08,680 COUPLE YEARS FROM NOW TO -- 3739 02:20:08,680 --> 02:20:09,000 >> WELL, OKAY. 3740 02:20:09,000 --> 02:20:12,040 THEY HAVE THE EQUIPMENT RIGHT 3741 02:20:12,040 --> 02:20:12,600 NOW. 3742 02:20:12,600 --> 02:20:14,000 THIS SO-CALLED TINY EQUIPMENT. 3743 02:20:14,000 --> 02:20:16,000 THAT CAN ACTUALLY GIVE YOU A 3744 02:20:16,000 --> 02:20:16,240 READOUT. 3745 02:20:16,240 --> 02:20:19,520 IT CAN GIVE A LOAD OF VIRUS 3746 02:20:19,520 --> 02:20:21,560 THAT'S IN THE SAMPLE, AND I 3747 02:20:21,560 --> 02:20:26,840 THINK NOW IT NEEDS TO BE BETA 3748 02:20:26,840 --> 02:20:29,240 TESTED, AND NOT SURE -- 3749 02:20:29,240 --> 02:20:30,120 SOMETHING LIKE THAT PROBABLY 3750 02:20:30,120 --> 02:20:31,640 WOULD HAVE TO GO THROUGH FDA 3751 02:20:31,640 --> 02:20:34,560 APPROVAL BEFORE IT WILL GET TO 3752 02:20:34,560 --> 02:20:35,360 THE STATES FOR DISSEMINATION, 3753 02:20:35,360 --> 02:20:40,000 CERTAINLY IN THE U.S. 3754 02:20:40,000 --> 02:20:41,680 NOW, IN THE SOUTH AFRICA, 3755 02:20:41,680 --> 02:20:44,680 TREATMENT ASSISTANT, THEY HAVE 3756 02:20:44,680 --> 02:20:49,920 GOTTEN I THINK SOUTH AFRICAN FDA 3757 02:20:49,920 --> 02:20:50,880 APPROVAL, IT CAN START BEING 3758 02:20:50,880 --> 02:20:51,880 TESTED IN THE FIELD OUT THERE. 3759 02:20:51,880 --> 02:20:53,840 BUT IN THE U.S. WOULD HAVE TO 3760 02:20:53,840 --> 02:20:55,000 WAIT TO GET APPROVAL. 3761 02:20:55,000 --> 02:20:56,680 BUT I THINK IT WOULD BE 3762 02:20:56,680 --> 02:20:57,160 EXCITING. 3763 02:20:57,160 --> 02:20:59,840 I GUESS THIS IS WHERE YOU DRIVE, 3764 02:20:59,840 --> 02:21:01,320 THAT IT COULD BE USEFUL LIVING 3765 02:21:01,320 --> 02:21:03,120 IN THE U.S. IF IT GETS TO THAT 3766 02:21:03,120 --> 02:21:04,280 STAGE BUT I DON'T THINK THEY ARE 3767 02:21:04,280 --> 02:21:05,680 THERE YET. 3768 02:21:05,680 --> 02:21:07,760 THEY NEED TO BETA TEST AND 3769 02:21:07,760 --> 02:21:09,800 POSSIBLY REFINE A FEW FEATURES 3770 02:21:09,800 --> 02:21:11,320 OF IT. 3771 02:21:11,320 --> 02:21:12,280 >> YEAH, THAT'S GREAT 3772 02:21:12,280 --> 02:21:13,320 VALIDATION. 3773 02:21:13,320 --> 02:21:15,200 IT WILL BE IMPORTANT. 3774 02:21:15,200 --> 02:21:17,400 SO THE NCAB NEEDS TO VOTE TO 3775 02:21:17,400 --> 02:21:21,240 ACCEPT THE REPORT THAT WAS 3776 02:21:21,240 --> 02:21:22,760 PRESENTED BY DR. ALI-OSMAN. 3777 02:21:22,760 --> 02:21:24,960 DO WE HAVE A MOTION TO ACCEPT 3778 02:21:24,960 --> 02:21:25,760 THE REPORT? 3779 02:21:25,760 --> 02:21:31,440 >> MOTION TO ACCEPT IT. 3780 02:21:31,440 --> 02:21:31,760 >> SECOND? 3781 02:21:31,760 --> 02:21:32,360 DISCUSSION? 3782 02:21:32,360 --> 02:21:32,560 GREAT. 3783 02:21:32,560 --> 02:21:34,960 CAN I FIRST SEE HANDS FOR THOSE 3784 02:21:34,960 --> 02:21:40,000 WHO VOTE YAY TO ACCEPT? 3785 02:21:40,000 --> 02:21:44,200 ANYONE VOTE NAY? 3786 02:21:44,200 --> 02:21:46,720 ANYONE ABSTAINING? 3787 02:21:46,720 --> 02:21:50,960 >> DID I SEE ONE NAY? 3788 02:21:50,960 --> 02:21:52,960 3789 02:21:52,960 --> 02:21:53,520 >> NO. 3790 02:21:53,520 --> 02:21:55,640 NO, NO. 3791 02:21:55,640 --> 02:21:55,840 OKAY. 3792 02:21:55,840 --> 02:21:56,120 >> OKAY. 3793 02:21:56,120 --> 02:21:57,200 >> THANKS, PAULETTE. 3794 02:21:57,200 --> 02:22:03,760 SO, THE YAYS HAVE IT. 3795 02:22:03,760 --> 02:22:03,920 3796 02:22:03,920 --> 02:22:04,440 YES, PAULETTE? 3797 02:22:04,440 --> 02:22:10,160 >> WHILE WE START THE NEXT 3798 02:22:10,160 --> 02:22:13,360 MEETING, ASK FOR YAYS, NOT THE 3799 02:22:13,360 --> 02:22:13,960 NAYS. 3800 02:22:13,960 --> 02:22:14,240 >> GOT IT. 3801 02:22:14,240 --> 02:22:17,920 THANK YOU. 3802 02:22:17,920 --> 02:22:19,600 >> MY CONNECTION WENT OUT. 3803 02:22:19,600 --> 02:22:20,520 I'M SORRY. 3804 02:22:20,520 --> 02:22:22,960 I'M NOT SURE WHY. 3805 02:22:22,960 --> 02:22:24,640 >> PRIOR TO ADJOURNING THE OPEN 3806 02:22:24,640 --> 02:22:26,560 SESSION, ARE THERE ANY OTHER 3807 02:22:26,560 --> 02:22:27,960 ISSUES THAT NEED TO BE 3808 02:22:27,960 --> 02:22:30,360 ADDRESSED? 3809 02:22:30,360 --> 02:22:32,200 3810 02:22:32,200 --> 02:22:35,680 IF NOT, WE COULD ALSO TAKE SOME 3811 02:22:35,680 --> 02:22:37,360 SUGGESTIONS FOR FUTURE AGENDA 3812 02:22:37,360 --> 02:22:41,640 ITEMS, IF SO PLEASE SEND THOSE 3813 02:22:41,640 --> 02:22:42,800 TO ME AND PAULETTE. 3814 02:22:42,800 --> 02:22:43,520 AND SO THIS CLOSES THE OPEN 3815 02:22:43,520 --> 02:22:44,760 SESSION FOR THE FEBRUARY NCAB 3816 02:22:44,760 --> 00:00:00,000 MEETING.