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>> I'M WALTER KOROSHETZ.

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OUR STAFF IS HERE, A BEAUTIFUL

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DAY IN WASHINGTON, D.C.,

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SPRING-LIKE.

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I WANT TO RECOGNIZE THE WORK --

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OH.

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I WANT TO RECOGNIZE ALL THE WORK

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THE STAFF HAS DONE IN TERMS OF

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GETTING US READY FOR COUNCIL AND

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DAY TO DAY AND PROUD OF WHAT THE

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INSTITUTE HAS ACCOMPLISHED.

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I HAVE TO START BY SAYING IN THE

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PURSUIT OF OUR MISSION, THE

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ADVANCED UNDERSTANDING OF THE

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BRAIN, NERVOUS SYSTEM, TO USE

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THAT KNOWLEDGE TO REDUCE

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SUFFERING DUE TO NEUROLOGICAL

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DISORDERS, THERE ARE A LOT OF 

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PEOPLE OUT THERE WHO WE HAVEN'T

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DEVELOPED TREATMENTS THAT ARE

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NEEDED AND WANT FOLKS TO KNOW

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WE'RE WORKING HARD WITH URGENCY

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TO TRY TO IMPROVE THE TREATMENT

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OF NEUROLOGICAL DISORDERS AND

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STROKE.

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SO, WE HAVE A NUMBER OF COUNCIL

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MEMBERS WHO ARE HERE ON ZOOM,

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ALSO WE HAVE WHAT WE CALL AD HOC

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COUNCIL MEMBERS AWAITING 

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CONFIRMATION FROM THE SECRETARY.

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FIRST A DAN, THE FOUNDER AND ON

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THE BOARD OF -- CHAIR OF TARGET

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ALS, A MEDICAL RESEARCH

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FOUNDATION WHICH HE FOUNDED IN

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2010 TO DEVELOP BETTER

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TREATMENTS FOR ALS. 

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A DISTINGUISHED BACKGROUND,

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PRESIDENT AND CHIEF EXECUTIVE

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OFFICER OF BLOOMBERG  AP,

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UNFORTUNATELY DEVELOPED ALS

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HIMSELF, HAD A FAMILY HISTORY OF

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ALS AND THEN DEVELOPED SPORADIC

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FORM, HE'S A PERSON WITH LIVED

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EXPERIENCE ON OUR COUNCIL.

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HE ATTENDED A LAW SCHOOL

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UNIVERSITY OF CHICAGO 1984,

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DOCTOR OF LAW, AND I THINK WE

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MAY HAVE OVERLAPPED BY ONE YEAR,

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DAN, BUT I WAS ON THE MEDICAL 

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SIDE.

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FLORIAN IECHLER, DIRECTOR OF

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NEUROGENICS AND GENE THERAPY

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HARVARD MEDICAL SCHOOL,

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ASSOCIATE PROFESSOR.

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FOCUSES ON GENETICS OF

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PAROXYSMAL DISORDERS, LIVER

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METABOLISM, ENGAGED IN

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DEVELOPMENT OF NEW THERAPY,

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GENOMIC THERAPIES FOR

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LEUKODYSTROPHY, M.D. 1997

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UNIVERSITY OF VIENNA SCHOOL OF

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MEDICINE, TRAINED AT MASS

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GENERAL IN NEUROLOGY.

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ROBERT GERAU IS NEXT, VICE CHAIR

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FOR RESEARCH AND DIRECTOR OF 

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WASHINGTON UNIVERSITY PAIN

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CENTER.

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VERY WELL KNOWN RESPECTED

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RESEARCHER IN THE PAIN FIELD.

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HE IS ON THE HEAL INITIATIVE

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MULTI-DISCIPLINARY WORKING GROUP

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WHICH GOES OVER ALL THE ASPECTS

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OF "HEAL," PRIOR TO THEIR COMING

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TO THE COUNCIL.

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SO HE'S A LINK BETWEEN THE

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"HEAL" MULTI-DISCIPLINARY

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WORKING GROUP, LANDIS AWARD,

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Ph.D. IN NEUROSCIENCE FROM

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EMORY UNIVERSITY IN 1995.

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NEXT FRANCES JENSEN, PROFESSOR

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AND CHAIR OF NEUROLOGY AT

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UNIVERSITY OF PERSON.

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SHE TRAINED AND WORKED FOR A

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LONG TIME AT CHILDREN'S HOSPITAL

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IN BOSTON BEFORE MOVING TO U

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PENN, BUILT A TREMENDOUS PROGRAM

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THERE AT U PENN, ON THE CLINICAL

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AND RESEARCH SIDE.

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SHE'S A HIGHLY RESPECTED

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RESEARCHER IN EPILEPSY AND

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JAVITS AWARD RECIPIENT.

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M.D. FROM CORNELL 1983.

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NEXT AMY McGWIRE, PROFESSOR OF

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BIOMEDICAL ETHICS, BAYLOR

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COLLEGE OF MEDICINE, A MEMBER OF

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THE NATIONAL ADVISORY COUNCIL,

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HUMAN GENOME RESEARCH, NUMEROUS

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TEACHING AWARDS AT BAYLOR

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COLLEGE OF MEDICINE, EARNED HER

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J.D. FROM UNIVERSITY OF HOUSTON

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LAW SCHOOL IN 2000, Ph.D. FROM

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UNIVERSITY OF TEXAS IN 2004.

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NEXT IS KATE NICHOLSON,

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EXECUTIVE DIRECTORY AND FOUNDER

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OF NATIONAL PAIN ADVOCACY

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CENTER, NATIONAL NON-PROFIT

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DEDICATED TO ADVANCING HEALTH

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AND HUMAN RIGHTS OF PEOPLE IN

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PAIN, SHE'S A CIVIL RIGHTS

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ATTORNEY, NATIONALLY RECOGNIZED

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EXPERT ON AMERICANS WITH

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DISABILITIES, AND SHE RECEIVED

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HER J.D. WITH HONORS FROM 

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HARVARD LAW SCHOOL IN 1992.

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THOSE ARE THE FOLKS THAT ARE

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JOINING US.

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AS YOU CAN SEE, TREMENDOUS

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EXPERTISE COMING TO THE COUNCIL

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ON THIS ROUND, AND LOOK FORWARD

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TO THEIR INPUT TODAY AND IN THE

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FUTURE.

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THANKS TO THE SITTING COUNCIL

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MEMBERS AS WELL.

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I'LL TURN IT OVER TO DAVE OWENS,

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ACTING DIRECTOR OF EXTRAMURAL

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ACTIVITIES.

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>> I'M EXECUTIVE SECRETARY
OF

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COUNCIL, I WANT TO WELCOME OUR

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AD HOC MEMBERS AND I WANT TO SAY

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WELCOME TO THE PREVIOUS AD HOC

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MEMBERS, WHO ARE NOW APPROVED BY

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THE SECRETARY, NOW FULL VOTING

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MEMBERS OF COUNCIL.

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I WANT TO REMIND EVERYONE WE'RE

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VIDEOCASTING, LIVE, FOLKS IN THE

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WORLD CAN SEE US ALL.

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NOW IT'S A REMOTE MEETING.

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WE WANT EVERYONE TO HAVE THEIR

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COMPUTERS ON AND MUTED AND THEIR

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SPEAKERS OFF SO WE CAN SEE YOUR

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FACES.

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AND THEN THERE WAS FINALLY ONE

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HOUSEKEEPING ITEM BEFORE I GO

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ON.

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THIS TIME -- I'LL NEED TO UNMUTE

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MYSELF, I DON'T THINK I'LL DO

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THAT.

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WE'RE GOING TO BE USING THE

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ELECTRONIC COUNCIL BOOK FOR

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VOTING THIS TIME.

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THIS IS A BETTER WAY TO APPROACH

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THE WHOLE PROCESS TO VOTING IN

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ZOOM, FOR EXAMPLE, BUT IT IS

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NEW.

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SO WE MAY BE WORKING OUT SOUGHT

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KINKS IN THE PROCESS.

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THE KEY VARIABLES NOW ALL THE

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COUNCIL MEMBERS SHOULD BE LOGGED

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INTO THE ECB.

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WE'VE SENT INSTRUCTIONS ON HOW

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TO VOTE.

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AS I SAID, THIS IS NEW, SO TIM

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LIEDEN NEXT TO ME AND CHERYL

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WILL BE ASSISTING US WITH THIS

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AS WE WORK THROUGH THIS.

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FOR THOSE WHO MAY BE IN

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CONFLICT, YOU CAN SEE YOU WILL

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BE UNABLE TO VOTE ON SOMETHING,

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THAT'S TAKEN CARE OF THERE.

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NOW, WE DO BELIEVE THIS IS GOING

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TO BE A BETTER WAY FORWARD BUT

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WE'LL HAVE SOME PATIENCE AS WE

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WORK THROUGH THIS FOR THE FIRST

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TIME.

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SO ARE THERE ANY QUESTIONS ABOUT

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THAT?

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HEARING NONE, I'LL MOVE ALONG.

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FIRST THING WE NEED TO CONSIDER

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IS PREVIOUS MINUTES.

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WE DID HAVE AN OFF-SCHEDULE

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AUGUST 23 COUNCIL MEETING.

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WE HAVE THE MINUTES, IN THE ECB.

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IF YOU'VE REVIEWED THOSE ARE

184
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THERE ANY QUESTIONS ON THOSE

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MINUTES?

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187
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HEARING NONE I WOULD LIKE A

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MOTION TO APPROVE THOSE MINUTES.

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>> SO MOVED.

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>> SO MOVED.

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>> SECOND?

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>> SECOND.

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>> SECOND.

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>> OKAY.

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NOW I'M GOING TO PASS TO TIM,

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WE'LL VOTE ON THOSE IN THE BOOK.

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FIRST HISTORIC VOTE IN ECB.

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>> YOU CAN LOOK IN THE
VOTING

199
00:08:23,842 --> 00:08:29,381
TAB, THE FIRST TAB IN THE ECB. 

200
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YOU JUST CLICK ON COUNCIL

201
00:08:31,350 --> 00:08:32,684
MEETING MINUTES, AND THEN YOU'LL

202
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SEE BOTH THE AUGUST AND FALL

203
00:08:35,821 --> 00:08:37,489
COUNCIL MEETING MINUTES AND YOU

204
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CAN VOTE, YES, YOU CAN SEE AN

205
00:08:39,358 --> 00:08:41,860
OPTION TO VOTE YES TO ALL.

206
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AND THEN MAKE SURE YOU HIT VOTE

207
00:08:44,630 --> 00:08:53,138
AND SUBMIT.

208
00:08:53,138 --> 00:08:57,409
CHIME IN IF YOU HAVE ISSUES.

209
00:08:57,409 --> 00:09:04,182
>> WE'LL MADE TO GET THE
VOTE

210
00:09:04,182 --> 00:09:05,918
BEFORE MOVING FORWARD.

211
00:09:05,918 --> 00:09:07,352
>> TO CLARIFY AD HOC
MEMBERS

212
00:09:07,352 --> 00:09:08,554
SHOULD NOT VOTE?

213
00:09:08,554 --> 00:09:09,555
>> CORRECT.

214
00:09:09,555 --> 00:09:10,622
I SHOULD HAVE MENTIONED.

215
00:09:10,622 --> 00:09:16,228
AS AD HOC YOU CAN PARTICIPATE IN

216
00:09:16,228 --> 00:09:17,329
ALL DISCUSSIONS, WE ENCOURAGE

217
00:09:17,329 --> 00:09:19,298
YOU TO DO SO, YET YOU CANNOT

218
00:09:19,298 --> 00:09:19,831
VOTE.

219
00:09:19,831 --> 00:09:22,334
>> I WAS AD HOC AT THE
LAST

220
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MEETING.

221
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DOES THAT MEAN I SHOULDN'T VOTE?

222
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>> YOU CAN VOTE.

223
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>> OKAY.

224
00:09:31,610 --> 00:09:34,546
>> DON'T EVEN HAVE A TAB.

225
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>> AD HOCS CANNOT VOTE.

226
00:09:36,415 --> 00:09:37,382
IF YOU'VE BEEN OFFICIALLY A

227
00:09:37,382 --> 00:09:38,483
COUNCIL MEMBER YOU CAN VOTE.

228
00:09:38,483 --> 00:09:40,986
IF YOU SEE THE VOTING TAB, YOU

229
00:09:40,986 --> 00:09:42,321
CAN VOTE.

230
00:09:42,321 --> 00:09:45,057
AND WE HAVE QUORUM.

231
00:09:45,057 --> 00:09:46,224
>> A QUORUM AND VOTE.

232
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EXCELLENT.

233
00:09:46,758 --> 00:09:48,327
WE'LL MOVE TO THE NEXT SET FROM

234
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THE FALL 23 COUNCIL MEETING.

235
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FIRST I WILL SAY ARE THERE ANY

236
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QUESTIONS ON THOSE MINUTES?

237
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HEARING NONE, IS THERE A MOTION

238
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TO APPROVE THOSE MINUTES?

239
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>> I MOTION TO APPROVE.

240
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>> SECOND?

241
00:10:03,642 --> 00:10:04,309
>> SECOND.

242
00:10:04,309 --> 00:10:04,977
>> TAKE IT AWAY.

243
00:10:04,977 --> 00:10:07,145
>> TIM, SOMEHOW I'M NOT
ABLE TO

244
00:10:07,145 --> 00:10:10,616
ACTIVATE YES OR NO ON MY --

245
00:10:10,616 --> 00:10:13,385
>> DID YOU ALREADY VOTE
ONCE?

246
00:10:13,385 --> 00:10:17,889
YOU MIGHT HAVE ALREADY VOTED.

247
00:10:17,889 --> 00:10:20,392
THEY ARE SEPARATE TABS I TAKE

248
00:10:20,392 --> 00:10:20,826
IT.

249
00:10:20,826 --> 00:10:23,595
IT'S THE SAME TAB, LIST THE

250
00:10:23,595 --> 00:10:27,099
RIGHT UNDERNEATH EACH OTHER.

251
00:10:27,099 --> 00:10:27,766
>> QUESTION.

252
00:10:27,766 --> 00:10:28,033
>> YES.

253
00:10:28,033 --> 00:10:29,935
>> DOES IT MATTER THAT THE
TOTAL

254
00:10:29,935 --> 00:10:31,803
VOTE TAB WE'RE SEEING IS NOT

255
00:10:31,803 --> 00:10:32,904
VERY LARGE?

256
00:10:32,904 --> 00:10:37,943
IT SAYS FIVE VOTES SO FAR. 

257
00:10:37,943 --> 00:10:41,747
>> WHEN WE GET A QUORUM
VOTE,

258
00:10:41,747 --> 00:10:43,949
WE'RE FINE TO MOVE FORWARD, MY

259
00:10:43,949 --> 00:10:45,050
UNDERSTANDING AT LEAST ON

260
00:10:45,050 --> 00:10:47,119
PREVIOUS MINUTES WE HAD REACHED

261
00:10:47,119 --> 00:10:47,719
THAT THRESHOLD.

262
00:10:47,719 --> 00:10:48,420
THAT IS CORRECT.

263
00:10:48,420 --> 00:10:51,056
>> I MEAN THAT'S FINE?

264
00:10:51,056 --> 00:10:52,491
IT SAYS TOTAL YES, FIVE?

265
00:10:52,491 --> 00:10:54,626
I WANT TO MAKE SURE THERE'S NOT

266
00:10:54,626 --> 00:10:56,094
SOME GLITCH THAT WILL FOUL UP

267
00:10:56,094 --> 00:10:57,629
YOUR COUNTING WHEN YOU LOOK

268
00:10:57,629 --> 00:10:57,929
BACK.

269
00:10:57,929 --> 00:11:01,566
>> I'M SEEING NONE.

270
00:11:01,566 --> 00:11:03,335
>> I SEE EIGHT.

271
00:11:03,335 --> 00:11:05,303
>> BOB, ON OUR END IT
LOOKS

272
00:11:05,303 --> 00:11:05,537
FINE.

273
00:11:05,537 --> 00:11:07,406
SO I THINK WE'RE GOOD.

274
00:11:07,406 --> 00:11:10,642
>> THANK YOU.

275
00:11:10,642 --> 00:11:11,710
>> LET ME KNOW --

276
00:11:11,710 --> 00:11:12,411
>> WE'RE GOOD?

277
00:11:12,411 --> 00:11:13,045
>> WE'RE GOOD.

278
00:11:13,045 --> 00:11:14,179
WE TOOK CARE OF THE MINUTES.

279
00:11:14,179 --> 00:11:15,681
VERY GOOD.

280
00:11:15,681 --> 00:11:16,581
THANK YOU, EVERYONE.

281
00:11:16,581 --> 00:11:20,052
THE NEXT ITEM IS CONFIRMATION OF

282
00:11:20,052 --> 00:11:21,286
FUTURE COUNCIL MEETINGS, SHOULD

283
00:11:21,286 --> 00:11:22,821
ALSO BE IN THE ECB.

284
00:11:22,821 --> 00:11:26,425
WHAT WE'RE ASKING IS FOR FOLKS 

285
00:11:26,425 --> 00:11:28,193
TO SET THAT ASIDE AND BLOCK THEM

286
00:11:28,193 --> 00:11:28,927
OFF ON YOUR CALENDAR.

287
00:11:28,927 --> 00:11:31,129
I DON'T THINK I'LL READ THEM BUT

288
00:11:31,129 --> 00:11:33,965
WILL MENTION THE NEXT COUNCIL

289
00:11:33,965 --> 00:11:36,034
MEETING IN MAY WILL BE LIVE, OR

290
00:11:36,034 --> 00:11:36,802
FACE TO FACE.

291
00:11:36,802 --> 00:11:40,872
IT WILL NOT BE VIRTUAL.

292
00:11:40,872 --> 00:11:41,506
OKAY.

293
00:11:41,506 --> 00:11:42,641
AND THEN MOVING ALONG --

294
00:11:42,641 --> 00:11:44,242
>> SORRY, WHERE IS THAT

295
00:11:44,242 --> 00:11:44,643
INFORMATION?

296
00:11:44,643 --> 00:11:45,877
>> I DON'T SEE IT EITHER.

297
00:11:45,877 --> 00:11:47,112
>> THERE'S NO VOTE.

298
00:11:47,112 --> 00:11:48,947
WE'RE JUST ASKING YOU TO BLOCK

299
00:11:48,947 --> 00:11:50,348
YOUR CALENDARS.

300
00:11:50,348 --> 00:11:54,186
THEY SHOULD BE IN THE ECB, THOSE

301
00:11:54,186 --> 00:11:55,520
MEETING DATES.

302
00:11:55,520 --> 00:11:56,722
>> WHERE IN THE ECB?

303
00:11:56,722 --> 00:12:00,225
>> IT'S LISTED ON THE
AGENDA

304
00:12:00,225 --> 00:12:01,860
DOCUMENT.

305
00:12:01,860 --> 00:12:06,231
>> WHERE IS THE AGENDA
DOCUMENT?

306
00:12:06,231 --> 00:12:07,165
>> IT'S IN THE GENERAL

307
00:12:07,165 --> 00:12:12,571
INFORMATION TAB. 

308
00:12:12,571 --> 00:12:14,673
>> TIM OR DAVID?

309
00:12:14,673 --> 00:12:14,940
>> YES?

310
00:12:14,940 --> 00:12:16,942
>> FOR THOSE THAT ARE
SUPPOSED

311
00:12:16,942 --> 00:12:18,176
TO ROTATE OFF AFTER MAY DO YOU

312
00:12:18,176 --> 00:12:19,511
WANT US TO KEEP A HOLD ON

313
00:12:19,511 --> 00:12:21,646
SEPTEMBER BECAUSE OF THE DELAYS

314
00:12:21,646 --> 00:12:26,151
IN GETTING PEOPLE TO REPLACE US?

315
00:12:26,151 --> 00:12:26,418
>> YES.

316
00:12:26,418 --> 00:12:28,019
>> YEAH, I THINK THAT
WOULD BE A

317
00:12:28,019 --> 00:12:31,623
GOOD IDEA. 

318
00:12:31,623 --> 00:12:33,358
WE WOULD APPRECIATE THAT.

319
00:12:33,358 --> 00:12:34,092
YOU NEVER KNOW

320
00:12:34,092 --> 00:12:36,862
>> DO YOU KNOW HOW MUCH WE
LOVE

321
00:12:36,862 --> 00:12:37,395
NIH SERVICE?

322
00:12:37,395 --> 00:12:39,698
>> YES, IT'S A WONDERFUL

323
00:12:39,698 --> 00:12:40,031
EXPERIENCE.

324
00:12:40,031 --> 00:12:41,566
I'M GOING TO GIVE EVERYONE A

325
00:12:41,566 --> 00:12:51,910
MINUTE SO WE ALL GET ORIENTED.

326
00:12:51,910 --> 00:12:54,980
>> I HAVE TO ASK, WHERE IS
THE

327
00:12:54,980 --> 00:12:56,481
GENERAL INFORMATION TAB?

328
00:12:56,481 --> 00:12:57,716
I HAVE MISCELLANEOUS, ET CETERA.

329
00:12:57,716 --> 00:13:01,853
DON'T SEE INFORMATION.

330
00:13:01,853 --> 00:13:02,721
>> IT'S WINTER 2024
COUNCIL,

331
00:13:02,721 --> 00:13:04,790
RIGHT NEXT TO THE CLOSED

332
00:13:04,790 --> 00:13:05,857
SESSION.

333
00:13:05,857 --> 00:13:06,792
>> THANK YOU.

334
00:13:06,792 --> 00:13:08,426
GOT IT.

335
00:13:08,426 --> 00:13:09,294
PERFECT.

336
00:13:09,294 --> 00:13:10,128
THANKS.

337
00:13:10,128 --> 00:13:10,428
>> RIGHT.

338
00:13:10,428 --> 00:13:12,597
AND, AGAIN, IT'S FIND THAT WE

339
00:13:12,597 --> 00:13:13,598
WORK THROUGH THIS.

340
00:13:13,598 --> 00:13:13,899
OKAY.

341
00:13:13,899 --> 00:13:16,535
SO THE NEXT ITEM IS THE

342
00:13:16,535 --> 00:13:17,202
EXPEDITED REVIEW PROCESS.

343
00:13:17,202 --> 00:13:19,271
WHAT THIS IS IS EACH ROUND WE

344
00:13:19,271 --> 00:13:21,139
IDENTIFY CERTAIN GRANTS THAT WE

345
00:13:21,139 --> 00:13:24,543
CAN EXPEDITE AND GET OUT THE

346
00:13:24,543 --> 00:13:25,544
DOOR QUICKER.

347
00:13:25,544 --> 00:13:30,916
GENERALLY WHAT THESE WILL COVER

348
00:13:30,916 --> 00:13:33,084
ARE R01s WITH NO

349
00:13:33,084 --> 00:13:36,588
ADMINISTRATIVE ISSUES. 

350
00:13:36,588 --> 00:13:44,796
THIS TIME AMY, TIM, LOUISE.

351
00:13:44,796 --> 00:13:45,664
WE APPRECIATE YOUR WORK.

352
00:13:45,664 --> 00:13:51,803
AND THIS IS A TESTAMENT TO OUR

353
00:13:51,803 --> 00:13:52,571
GRANTS MANAGEMENT DIVISION,

354
00:13:52,571 --> 00:13:55,106
CHAIRED OR LED BY SHELLY WILBURN

355
00:13:55,106 --> 00:13:57,042
AND PROGRAM STAFF WHO MAKE SURE

356
00:13:57,042 --> 00:13:59,244
Is ARE DOTTED AND Ts ARE

357
00:13:59,244 --> 00:14:01,780
CROSSED TO GET THESE GRANTS OUT

358
00:14:01,780 --> 00:14:02,747
FAST.

359
00:14:02,747 --> 00:14:03,148
OKAY.

360
00:14:03,148 --> 00:14:06,151
NOW I'M GOING TO MOVE TO THE

361
00:14:06,151 --> 00:14:07,018
SECTION OF EXTRAMURAL

362
00:14:07,018 --> 00:14:07,552
ANNOUNCEMENTS.

363
00:14:07,552 --> 00:14:09,187
WE HAVE A SLIDE FOR THAT.

364
00:14:09,187 --> 00:14:13,658
THIS IS GOING TO BE OUR -- THE

365
00:14:13,658 --> 00:14:15,961
BIOS FOR OUR STAFF ARE IN THE

366
00:14:15,961 --> 00:14:17,729
ECB AND WE HAVE NOT ENOUGH TIME

367
00:14:17,729 --> 00:14:18,830
TO ESSENTIALLY GO THROUGH EACH

368
00:14:18,830 --> 00:14:21,333
ONE SO WE'RE GOING TO PUT UP A

369
00:14:21,333 --> 00:14:26,504
SLIDE AND ALL TAKE A LOOK AND 

370
00:14:26,504 --> 00:14:28,573
SEE THE STAFFING UPDATES.

371
00:14:28,573 --> 00:14:30,008
WE ENCOURAGE YOU TO READ ABOUT

372
00:14:30,008 --> 00:14:37,649
THIS IN THE BOOK. 

373
00:14:37,649 --> 00:14:39,184
>> IS THAT IT?

374
00:14:39,184 --> 00:14:39,618
JUST ONE SLIDE?

375
00:14:39,618 --> 00:14:44,356
THAT'S WHAT I THOUGHT. 

376
00:14:44,356 --> 00:14:44,689
NEXT?

377
00:14:44,689 --> 00:14:54,432
THERE WE GO. 

378
00:14:54,432 --> 00:14:55,400
SUPER, THANKS.

379
00:14:55,400 --> 00:14:55,834
OKAY.

380
00:14:55,834 --> 00:14:58,336
SO NOW WE'RE GOING TO TALK ABOUT

381
00:14:58,336 --> 00:15:00,205
THE COUNCIL OPERATING

382
00:15:00,205 --> 00:15:00,572
PROCEDURES.

383
00:15:00,572 --> 00:15:04,876
THESE ARE ESSENTIALLY THE RULES

384
00:15:04,876 --> 00:15:06,778
OF OUR INTERACTIONS, GUIDING

385
00:15:06,778 --> 00:15:07,512
INTERACTIONS WITH COUNCIL, HOW

386
00:15:07,512 --> 00:15:10,181
WE DO BUSINESS WITH YOU.

387
00:15:10,181 --> 00:15:11,816
THEY ARE IN THE ECB, FOR THE

388
00:15:11,816 --> 00:15:13,351
MOST PART WE'VE NOT MODIFIED

389
00:15:13,351 --> 00:15:14,452
EXCEPT FOR ONE THING WHICH I

390
00:15:14,452 --> 00:15:16,087
WANT TO MENTION AND DO WANT TO

391
00:15:16,087 --> 00:15:20,058
HEAR IF THERE'S ANY QUESTIONS ON

392
00:15:20,058 --> 00:15:20,258
THAT.

393
00:15:20,258 --> 00:15:21,459
SO, WE HAVE DELEGATED AUTHORITY

394
00:15:21,459 --> 00:15:24,229
TO ISSUE, FOR EXAMPLE,

395
00:15:24,229 --> 00:15:25,297
ADMINISTRATIVE SUPPLEMENTS BELOW

396
00:15:25,297 --> 00:15:27,365
$100,000 IN DIRECT COSTS WITHOUT

397
00:15:27,365 --> 00:15:29,567
COUNCIL CONCURRENCE.

398
00:15:29,567 --> 00:15:31,102
AND THAT HELPS US MOVE THINGS

399
00:15:31,102 --> 00:15:33,171
FORWARD QUICKLY.

400
00:15:33,171 --> 00:15:36,107
WE CAN DO CO-FUNDS OF LIMITED

401
00:15:36,107 --> 00:15:36,708
AMOUNT.

402
00:15:36,708 --> 00:15:39,844
WHAT WE WOULD LIKE TO ADD ARE

403
00:15:39,844 --> 00:15:41,479
R13 CONFERENCE GRANTS THAT

404
00:15:41,479 --> 00:15:44,215
SUPPORT A CONFERENCE, USUALLY A

405
00:15:44,215 --> 00:15:45,350
ONE-YEAR AWARD, OUR

406
00:15:45,350 --> 00:15:46,318
CONTRIBUTIONS ARE QUITE MODEST.

407
00:15:46,318 --> 00:15:48,586
FOR EXAMPLE, IN THE LAST YEAR I

408
00:15:48,586 --> 00:15:52,691
THINK THE AVERAGE AMOUNT WE

409
00:15:52,691 --> 00:15:54,392
AWARDED WAS $16,000 FOR A

410
00:15:54,392 --> 00:15:55,026
CONFERENCE.

411
00:15:55,026 --> 00:15:57,462
WE DO HAVE AN INTERNAL PROCESS

412
00:15:57,462 --> 00:16:00,632
WHERE IF THE AMOUNT OF THE AWARD

413
00:16:00,632 --> 00:16:03,268
IS HIGH, OR RELATIVELY HIGH,

414
00:16:03,268 --> 00:16:04,869
AND/OR IF THERE'S ISSUE WITH THE

415
00:16:04,869 --> 00:16:06,871
SUMMARY STATEMENT BECAUSE THEY

416
00:16:06,871 --> 00:16:08,740
ARE PEER REVIEWED BY OUR REVIEW

417
00:16:08,740 --> 00:16:10,175
BRANCH OR SEVERAL OTHER THINGS

418
00:16:10,175 --> 00:16:13,011
WE DO VET THESE.

419
00:16:13,011 --> 00:16:14,446
HOWEVER, WE HAVE RUN INTO ISSUES

420
00:16:14,446 --> 00:16:16,948
BECAUSE WE CAN'T MAKE AWARDS

421
00:16:16,948 --> 00:16:19,017
UNTIL WE HAVE COUNCIL APPROVAL,

422
00:16:19,017 --> 00:16:20,452
AND IF THE MEDIAN ALREADY

423
00:16:20,452 --> 00:16:22,954
OCCURRED WE CANNOT SUPPORT IT

424
00:16:22,954 --> 00:16:25,490
ANY LONGER, SO CONSIDERING THESE

425
00:16:25,490 --> 00:16:26,124
ARE PRETTY STRAIGHTFORWARD, NOT

426
00:16:26,124 --> 00:16:27,792
A LOT OF MONEY, THERE'S USUALLY

427
00:16:27,792 --> 00:16:29,527
FEW IF ANY ISSUES WITH THEM, WE

428
00:16:29,527 --> 00:16:31,997
WOULD LIKE TO ADD THESE TO OUR

429
00:16:31,997 --> 00:16:35,767
DELEGATED AUTHORITY TO UP TO

430
00:16:35,767 --> 00:16:36,001
$50,000.

431
00:16:36,001 --> 00:16:37,869
AND THEN WOULD GIVE US THE

432
00:16:37,869 --> 00:16:39,304
ABILITY WHEN THERE'S NO ISSUES

433
00:16:39,304 --> 00:16:42,807
TO GET AN AWARD OUT TO THE

434
00:16:42,807 --> 00:16:44,109
CONFERENCE QUICK SO WE WOULDN'T

435
00:16:44,109 --> 00:16:45,310
EVER MISS THIS FUNDING DEADLINE.

436
00:16:45,310 --> 00:16:47,946
WE WOULD LIKE TO ADD THAT ON OUR

437
00:16:47,946 --> 00:16:49,014
DELEGATED AUTHORITY BUT I WOULD

438
00:16:49,014 --> 00:16:50,815
LIKE TO HEAR IF THERE ARE ANY

439
00:16:50,815 --> 00:16:55,520
QUESTIONS ABOUT THAT.

440
00:16:55,520 --> 00:16:58,456
>> HOW OFTEN DO YOU HAVE
GRANT

441
00:16:58,456 --> 00:17:00,091
FUNDS REQUEST FOR THESE

442
00:17:00,091 --> 00:17:00,658
MEETINGS, $50?

443
00:17:00,658 --> 00:17:02,861
YOU MENTIONED THEY ARE TYPICALLY

444
00:17:02,861 --> 00:17:03,695
$16,000.

445
00:17:03,695 --> 00:17:04,529
IS THAT A RARE THINK?

446
00:17:04,529 --> 00:17:05,397
>> YES, EXTREMELY RARE.

447
00:17:05,397 --> 00:17:06,898
IN FACT WHEN I LOOKED, I LOOKED

448
00:17:06,898 --> 00:17:08,767
AT THE LAST YEAR NUMBERS, THE

449
00:17:08,767 --> 00:17:10,635
HIGHEST WE EVER AWARDED WAS

450
00:17:10,635 --> 00:17:12,604
$30,000, AND THAT WAS JUST FOR

451
00:17:12,604 --> 00:17:13,038
ONE.

452
00:17:13,038 --> 00:17:18,109
ALL THE OTHER ONES WERE BETWEEN

453
00:17:18,109 --> 00:17:18,843
$5,000 AND $25,000.

454
00:17:18,843 --> 00:17:21,012
>> WHY ARE YOU SETTING IT
FOR

455
00:17:21,012 --> 00:17:21,312
$50,000?

456
00:17:21,312 --> 00:17:22,680
>> IN CASE IT CAME UP THAT
WE

457
00:17:22,680 --> 00:17:23,281
WOULDN'T NECESSARILY WANT TO

458
00:17:23,281 --> 00:17:24,849
HOLD IT UP.

459
00:17:24,849 --> 00:17:26,918
NOW, ONE THING EVEN WHEN WE HAVE

460
00:17:26,918 --> 00:17:28,553
A DELEGATED AUTHORITY I WOULD

461
00:17:28,553 --> 00:17:29,888
SAY IF THERE WAS ANY ISSUE WE

462
00:17:29,888 --> 00:17:31,756
THOUGHT WE WOULD LIKE TO DISCUSS

463
00:17:31,756 --> 00:17:32,957
WITH COUNCIL, WE CAN.

464
00:17:32,957 --> 00:17:34,059
AND WE WOULD.

465
00:17:34,059 --> 00:17:36,061
SO IT'S JUST I THINK MAYBE AN

466
00:17:36,061 --> 00:17:37,996
UPPER THRESHOLD JUST TO BE ON

467
00:17:37,996 --> 00:17:38,530
THE SAFE SIDE.

468
00:17:38,530 --> 00:17:46,838
>> THANK YOU.

469
00:17:46,838 --> 00:17:48,039
THAT'S HELPFUL.

470
00:17:48,039 --> 00:17:50,241
>> ANY OTHER QUESTIONS ON
THAT?

471
00:17:50,241 --> 00:17:53,978
IF NOT IS THERE A MOTION TO MOVE

472
00:17:53,978 --> 00:17:58,683
FORWARD AND APPROVE OPERATING 

473
00:17:58,683 --> 00:17:59,117
PROCEDURES?

474
00:17:59,117 --> 00:17:59,984
>> I MOVE.

475
00:17:59,984 --> 00:18:00,285
>> SECOND?

476
00:18:00,285 --> 00:18:01,086
>> SECOND.

477
00:18:01,086 --> 00:18:06,758
>> GO TO THE VOTING TAB. 

478
00:18:06,758 --> 00:18:08,960
IF YOU RECALL, IT'S THE VOTE

479
00:18:08,960 --> 00:18:09,727
TAB.

480
00:18:09,727 --> 00:18:13,331
AND VOTE YES OR NO.

481
00:18:13,331 --> 00:18:19,337
 

482
00:18:19,337 --> 00:18:28,980
 

483
00:18:28,980 --> 00:18:31,716
>> I'M NOT -- IS THIS
OPERATING

484
00:18:31,716 --> 00:18:32,117
PROCEDURES?

485
00:18:32,117 --> 00:18:32,350
>> YES.

486
00:18:32,350 --> 00:18:34,652
>> OKAY.

487
00:18:34,652 --> 00:18:40,658
 

488
00:18:40,658 --> 00:18:42,861
 

489
00:18:42,861 --> 00:18:43,561
>> THANK YOU.

490
00:18:43,561 --> 00:18:46,798
AND WITH THAT I BELIEVE IT'S MY

491
00:18:46,798 --> 00:18:49,334
OPPORTUNITY TO PASS TO OUR

492
00:18:49,334 --> 00:18:54,038
DIRECTOR, WALTER KOROSHETZ, FOR

493
00:18:54,038 --> 00:18:55,373
HIS DIRECTOR'S REPORT.

494
00:18:55,373 --> 00:18:58,409
>> THANK YOU VERY MUCH,
DAVID.

495
00:18:58,409 --> 00:18:59,277
AND HOPEFULLY EVERYBODY IS

496
00:18:59,277 --> 00:19:03,681
GETTING USED TO THE NEW FORMAT.

497
00:19:03,681 --> 00:19:04,215
SHOULD WORK.

498
00:19:04,215 --> 00:19:07,585
COULD I HAVE THE SLIDES PLEASE?

499
00:19:07,585 --> 00:19:09,354
THIS IS THE DIRECTOR'S REPORT.

500
00:19:09,354 --> 00:19:10,221
THE DIRECTOR'S REPORT, WHAT I

501
00:19:10,221 --> 00:19:13,191
LIKE TO DO IS TRY TO GET ACROSS

502
00:19:13,191 --> 00:19:14,826
INFORMATION THAT I THINK MAY BE

503
00:19:14,826 --> 00:19:16,928
IMPORTANT TO THE COUNCIL, BUT

504
00:19:16,928 --> 00:19:21,733
ALSO TO THE GENERAL PUBLIC, WHO

505
00:19:21,733 --> 00:19:26,037
MAY BE VIEWING THIS REMOTELY.

506
00:19:26,037 --> 00:19:28,072
IN ADDITION, THESE -- I WILL GO

507
00:19:28,072 --> 00:19:31,476
THROUGH THE SLIDES BUT YOU WILL

508
00:19:31,476 --> 00:19:32,343
MAKE TAKEHOME POINTS BASICALLY,

509
00:19:32,343 --> 00:19:33,444
AND NOT GO THROUGH ALL THE

510
00:19:33,444 --> 00:19:36,047
MATERIALS ON THE SLIDE BUT THE

511
00:19:36,047 --> 00:19:37,148
SLIDES WILL BE AVAILABLE FOR

512
00:19:37,148 --> 00:19:38,249
PEOPLE TO SEE IF THEY ARE

513
00:19:38,249 --> 00:19:40,418
INTERESTED IN THE DETAIL.

514
00:19:40,418 --> 00:19:42,287
NEXT SLIDE PLEASE.

515
00:19:42,287 --> 00:19:45,356
SO, I THINK MOST IMPORTANTLY,

516
00:19:45,356 --> 00:19:48,626
FOR NIH, WE ARE REALLY GRATEFUL

517
00:19:48,626 --> 00:19:49,827
TO HAVE MONICA BERTAGNOLLI

518
00:19:49,827 --> 00:19:53,998
CONFIRMED AS THE NIH DIRECTOR.

519
00:19:53,998 --> 00:19:58,369
AND SHE MOVES FROM THE NCI TO

520
00:19:58,369 --> 00:19:59,904
THE NIH DIRECTOR POSITION, AND

521
00:19:59,904 --> 00:20:01,539
HAS REALLY TAKEN OVER.

522
00:20:01,539 --> 00:20:02,974
HAS BEEN A GREAT ADVOCATE FOR

523
00:20:02,974 --> 00:20:03,374
NIH.

524
00:20:03,374 --> 00:20:06,678
SHE HAS A NUMBER OF ITEMS THAT

525
00:20:06,678 --> 00:20:08,880
SHE WANTED US TO COMMUNICATE TO

526
00:20:08,880 --> 00:20:09,280
YOU.

527
00:20:09,280 --> 00:20:11,950
AND THAT IS THAT SOME OF HER

528
00:20:11,950 --> 00:20:15,453
GUIDING PRINCIPLES ARE SHE 

529
00:20:15,453 --> 00:20:17,655
REALLY WANTS TO IMPROVE THE

530
00:20:17,655 --> 00:20:20,291
INCLUSION OF PATIENTS AND

531
00:20:20,291 --> 00:20:22,794
SUBJECTS FROM ALL AREAS OF THE

532
00:20:22,794 --> 00:20:26,164
COUNTRY INTO OUR RESEARCH.

533
00:20:26,164 --> 00:20:29,033
AND SECONDLY, NEXT SLIDE, SHE

534
00:20:29,033 --> 00:20:31,869
WISHES TO REALLY BRING IN THE

535
00:20:31,869 --> 00:20:35,139
NEW TOOLS THAT ARE COMING, TO

536
00:20:35,139 --> 00:20:37,809
HELP ANALYZE LARGE AMOUNTS OF

537
00:20:37,809 --> 00:20:40,111
DATA FROM ARTIFICIAL

538
00:20:40,111 --> 00:20:41,846
INTELLIGENCE, AND MACHINE

539
00:20:41,846 --> 00:20:42,113
LEARNING.

540
00:20:42,113 --> 00:20:43,648
>> WALTER, WE'RE NOT
SEEING ANY

541
00:20:43,648 --> 00:20:43,982
SLIDES.

542
00:20:43,982 --> 00:20:44,682
>> ALL RIGHT.

543
00:20:44,682 --> 00:20:48,686
HOLD ON ONE SECOND, GUYS.

544
00:20:48,686 --> 00:20:53,891
 

545
00:20:53,891 --> 00:21:03,935
 

546
00:21:08,406 --> 00:21:09,540
 

547
00:21:09,540 --> 00:21:13,044
HOW ABOUT NOW? 

548
00:21:13,044 --> 00:21:14,679
DO YOU SEE SLIDES?

549
00:21:14,679 --> 00:21:14,879
OKAY.

550
00:21:14,879 --> 00:21:17,181
NEXT SLIDE HAS THE PICTURE OF

551
00:21:17,181 --> 00:21:19,951
OUR NEW DIRECTOR, VERY GOOD.

552
00:21:19,951 --> 00:21:21,452
AND THE NEXT SLIDE HAS ANOTHER

553
00:21:21,452 --> 00:21:26,090
PICTURE OF OUR NEW DIRECTOR,

554
00:21:26,090 --> 00:21:28,059
WITH THE MAJOR POINT BEING HER

555
00:21:28,059 --> 00:21:31,229
EFFORT TO BRING A NEW ANALYTICAL

556
00:21:31,229 --> 00:21:34,198
TECHNIQUES TO INCREASE THE VALUE

557
00:21:34,198 --> 00:21:38,536
OF NIH-FUNDED DATA.

558
00:21:38,536 --> 00:21:40,338
NEXT SLIDE.

559
00:21:40,338 --> 00:21:43,174
TARA SCHWETZ, WHO WAS THE ACTING

560
00:21:43,174 --> 00:21:44,842
DEPUTY DIRECTOR, HAS NOW MOVED

561
00:21:44,842 --> 00:21:47,111
TO BECOME THE DIRECTOR OF THE

562
00:21:47,111 --> 00:21:48,446
DIVISION FOR PROGRAM

563
00:21:48,446 --> 00:21:49,647
COORDINATION PLANNING AND

564
00:21:49,647 --> 00:21:50,315
STRATEGIC INITIATIVES.

565
00:21:50,315 --> 00:21:54,585
AND YOU CAN SEE HERE THE VARIETY

566
00:21:54,585 --> 00:21:56,354
OF OFFICES SHE OVERSEES.

567
00:21:56,354 --> 00:21:59,924
I THINK TO COME ON SOON IS HER

568
00:21:59,924 --> 00:22:00,725
OVERSIGHT OF THE COMMON FUND

569
00:22:00,725 --> 00:22:02,927
WHICH A NUMBER OF US ARE

570
00:22:02,927 --> 00:22:04,228
INVOLVED IN.

571
00:22:04,228 --> 00:22:05,530
NEXT SLIDE.

572
00:22:05,530 --> 00:22:07,065
ANOTHER MAJOR LEADERSHIP CHANGE

573
00:22:07,065 --> 00:22:12,303
AT NIH HAS BEEN RECRUITMENT OF

574
00:22:12,303 --> 00:22:15,707
KIM RATHMELL TO RUN THE NATIONAL

575
00:22:15,707 --> 00:22:16,507
CANCER INSTITUTE.

576
00:22:16,507 --> 00:22:20,645
SHE WAS CHAIR OF MEDICINE AT

577
00:22:20,645 --> 00:22:24,282
VANDERBILT, AN EXPERT IN KIDNEY

578
00:22:24,282 --> 00:22:26,351
CANCER, HAS A LOT OF WISDOM AND

579
00:22:26,351 --> 00:22:29,187
I THINK IS GOING TO BE A

580
00:22:29,187 --> 00:22:31,055
TREMENDOUS DIRECTOR FOR THE

581
00:22:31,055 --> 00:22:31,956
CANCER INSTITUTE AND LOOKING

582
00:22:31,956 --> 00:22:33,358
FORWARD TO TALKING TO HER AS I

583
00:22:33,358 --> 00:22:35,760
DO EVERY TIME THEY GET A NEW NCI

584
00:22:35,760 --> 00:22:39,130
DIRECTOR ABOUT HOW WE CAN MAKE A

585
00:22:39,130 --> 00:22:41,999
BIGGER DIFFERENCE TO IMPROVE THE

586
00:22:41,999 --> 00:22:44,936
LIVES OF PEOPLE WITH BRAIN

587
00:22:44,936 --> 00:22:45,737
TUMORS, PARTICULARLY

588
00:22:45,737 --> 00:22:46,070
GLIOBLASTOMA.

589
00:22:46,070 --> 00:22:47,271
I BROUGHT THAT UP.

590
00:22:47,271 --> 00:22:48,439
HOPEFULLY WE'LL GET TOGETHER

591
00:22:48,439 --> 00:22:48,673
SOON.

592
00:22:48,673 --> 00:22:49,741
NEXT SLIDE.

593
00:22:49,741 --> 00:22:54,178
THE OTHER LEADERSHIP CHANGE IS

594
00:22:54,178 --> 00:22:56,681
THE VERY RECENT RECRUITMENT SEAN

595
00:22:56,681 --> 00:22:59,951
MOONEY FROM THE UNIVERSITY OF

596
00:22:59,951 --> 00:23:00,818
WASHINGTON WHO RAN THEIR

597
00:23:00,818 --> 00:23:02,253
BIOINFORMATICAL INFORMATICS

598
00:23:02,253 --> 00:23:04,255
PROGRAM TO BECOME THE DIRECTOR

599
00:23:04,255 --> 00:23:07,425
OF THE CENTER FOR INFORMATION

600
00:23:07,425 --> 00:23:09,060
TECHNOLOGY HERE AT NIH, CIT, I

601
00:23:09,060 --> 00:23:11,496
SUSPECT HE WILL HAVE AN

602
00:23:11,496 --> 00:23:13,531
IMPORTANT ROLE IN DR.

603
00:23:13,531 --> 00:23:15,299
BERTAGNOLLI'S WORK TO BRING

604
00:23:15,299 --> 00:23:17,635
THESE NEW ANALYTIC TOOLS TO

605
00:23:17,635 --> 00:23:20,905
INCREASE THE VALUE OF NIH-FUNDED

606
00:23:20,905 --> 00:23:21,739
RESEARCH.

607
00:23:21,739 --> 00:23:22,774
NEXT SLIDE SHOWS LEADERSHIP

608
00:23:22,774 --> 00:23:23,975
CHANGES HERE WHICH YOU'VE

609
00:23:23,975 --> 00:23:26,110
ALREADY SEEN SOME OF.

610
00:23:26,110 --> 00:23:28,980
AND THAT IS THAT WITH THE

611
00:23:28,980 --> 00:23:31,516
DEPARTURE OF DR. FINKELSTEIN,

612
00:23:31,516 --> 00:23:33,251
DAVID OWENS HAS ABLY TAKEN OVER

613
00:23:33,251 --> 00:23:36,187
AS ACTING DIRECTOR OF THE

614
00:23:36,187 --> 00:23:46,531
DIVISION OF EXTRAMURAL 

615
00:23:46,531 --> 00:23:47,832
ACTIVITIES, AND DR. ANNA TAYLOR

616
00:23:47,832 --> 00:23:49,467
HAS MOVED IN, GRATEFUL FOR THEIR

617
00:23:49,467 --> 00:23:51,436
WORK MOVING US FORWARD, NOT

618
00:23:51,436 --> 00:23:52,403
LOSING A STEP.

619
00:23:52,403 --> 00:23:55,773
NEXT SLIDE IS A LITTLE BIT OF AN

620
00:23:55,773 --> 00:23:57,241
ADVERTISEMENT, AN IMPORTANT ONE

621
00:23:57,241 --> 00:24:00,711
TO MENTION THAT IS THAT THE --

622
00:24:00,711 --> 00:24:02,814
WE HAVE A CENTER FOR ALZHEIMER'S

623
00:24:02,814 --> 00:24:04,449
AND RELATED DEMENTIAS HERE ON

624
00:24:04,449 --> 00:24:06,517
THE INTRAMURAL CAMPUS, AND WE'RE

625
00:24:06,517 --> 00:24:09,053
CURRENTLY LOOKING FOR A CLINICAL

626
00:24:09,053 --> 00:24:11,689
DIRECTOR, ANDY SINGLETON RUNS

627
00:24:11,689 --> 00:24:13,658
THE CENTER, IT HAS A NEW

628
00:24:13,658 --> 00:24:14,425
BUILDING.

629
00:24:14,425 --> 00:24:15,626
IT'S VERY WELL RESOURCED, AND WE

630
00:24:15,626 --> 00:24:18,262
WOULD REALLY LIKE TO BRING IN

631
00:24:18,262 --> 00:24:22,400
SOMEONE WHO CAN DEVELOP AN

632
00:24:22,400 --> 00:24:25,169
AMBITIOUS CLINICAL PROGRAM, TO

633
00:24:25,169 --> 00:24:27,672
USE ALL THE RESOURCES OF THE

634
00:24:27,672 --> 00:24:29,740
CLINICAL CENTER, THE LARGEST

635
00:24:29,740 --> 00:24:32,376
RESEARCH HOSPITAL IN THE WORLD,

636
00:24:32,376 --> 00:24:34,245
TO ADVANCE OUR TREATMENTS FOR

637
00:24:34,245 --> 00:24:36,514
PEOPLE WITH ALZHEIMER'S AND

638
00:24:36,514 --> 00:24:37,448
RELATED DEMENTIA.

639
00:24:37,448 --> 00:24:40,451
IF PEOPLE COULD MESSAGE THAT

640
00:24:40,451 --> 00:24:43,287
AROUND, FEEL FREE TO GIVE ME A

641
00:24:43,287 --> 00:24:44,388
BUZZ, APPLICANTS.

642
00:24:44,388 --> 00:24:44,956
NEXT SLIDE.

643
00:24:44,956 --> 00:24:48,893
I WANT TO TALK AS I DO ABOUT THE

644
00:24:48,893 --> 00:24:49,894
BUDGET.

645
00:24:49,894 --> 00:24:51,095
AND THIS SLIDE BASICALLY SHOWS

646
00:24:51,095 --> 00:24:53,698
WHAT WE CALL THE BASE NINDS

647
00:24:53,698 --> 00:24:55,333
BUDGET, SO OUR BUDGET IS

648
00:24:55,333 --> 00:24:57,869
COMPOSED OF THE BASE MONEY BUT

649
00:24:57,869 --> 00:25:00,605
THEN THERE ARE ALSO MONEY THAT

650
00:25:00,605 --> 00:25:03,541
COMES FOR SPECIAL PROGRAMS, THIS

651
00:25:03,541 --> 00:25:05,576
IS THE BASE MONEY, AND CURRENTLY

652
00:25:05,576 --> 00:25:07,512
WE'RE OPERATING INTO WHAT'S

653
00:25:07,512 --> 00:25:09,347
CALLED A CONTINUING RESOLUTION.

654
00:25:09,347 --> 00:25:15,286
OTHERWISE KNOWN AS A C.R.

655
00:25:15,286 --> 00:25:18,456
AND UNFORTUNATELY THIS IS --

656
00:25:18,456 --> 00:25:19,557
MULTIPLE C.R.s THIS YEAR,

657
00:25:19,557 --> 00:25:21,192
POTENTIALLY FACING IF CONGRESS

658
00:25:21,192 --> 00:25:25,596
CANNOT DO A BUDGET A YEAR-LONG

659
00:25:25,596 --> 00:25:25,830
C.R.

660
00:25:25,830 --> 00:25:27,031
SO, THAT GENERALLY WOULD MEAN

661
00:25:27,031 --> 00:25:29,467
THAT WE HAVE A FLAT BUDGET BUT

662
00:25:29,467 --> 00:25:31,602
THAT IS NOT NECESSARILY THE CASE

663
00:25:31,602 --> 00:25:35,139
THIS YEAR, BECAUSE IN THE BUDGET

664
00:25:35,139 --> 00:25:37,542
DEAL AN AUTOMATIC 1% CUT GOES

665
00:25:37,542 --> 00:25:39,277
INTO EFFECT IN MAY SHOULD THERE

666
00:25:39,277 --> 00:25:42,880
NOT BE A BUDGETS BY JANUARY 1

667
00:25:42,880 --> 00:25:44,649
AND OF COURSE THERE WAS NOT A

668
00:25:44,649 --> 00:25:48,586
BUDGET BY JANUARY 1.

669
00:25:48,586 --> 00:25:50,922
A 1% DROP WOULD DROP AVAILABLE

670
00:25:50,922 --> 00:25:53,524
FUNDS BY $21 MILLION, AND THEN

671
00:25:53,524 --> 00:25:54,458
THERE'S ALSO THE POSSIBILITY

672
00:25:54,458 --> 00:25:57,562
THAT ALTHOUGH IT COULD BE A FLAT

673
00:25:57,562 --> 00:26:00,197
BUDGET TO THE AGENCY, THAT MONEY

674
00:26:00,197 --> 00:26:03,367
COULD BE REDISTRIBUTED AMONG THE

675
00:26:03,367 --> 00:26:05,369
DIFFERENT NON-DISCRETIONAL

676
00:26:05,369 --> 00:26:05,636
AGENCIES.

677
00:26:05,636 --> 00:26:07,438
SO, WE'RE STILL IN THE SPOT

678
00:26:07,438 --> 00:26:08,973
WHERE WE DON'T EXACTLY KNOW HOW

679
00:26:08,973 --> 00:26:13,978
MUCH FUNDING WE WILL HAVE GOING

680
00:26:13,978 --> 00:26:15,980
FORWARD, AND NEXT SLIDE, JUST TO

681
00:26:15,980 --> 00:26:17,615
TALK MORE ABOUT THIS ON THE NEXT

682
00:26:17,615 --> 00:26:23,087
SLIDE, SHOWS SOME OF THE OTHER

683
00:26:23,087 --> 00:26:26,257
SOURCES FOR FUNDING THAT NINDS

684
00:26:26,257 --> 00:26:30,795
MANAGES OR GETS THEIR

685
00:26:30,795 --> 00:26:31,128
APPROPRIATION.

686
00:26:31,128 --> 00:26:33,397
WE SEE A $280 MILLIONS FOR THE

687
00:26:33,397 --> 00:26:36,033
HEAL INITIATIVE, HELPING TO END

688
00:26:36,033 --> 00:26:36,667
ADDICTION LONG TERM.

689
00:26:36,667 --> 00:26:42,573
WE'LL TALK ABOUT THAT LATER.

690
00:26:42,573 --> 00:26:44,675
$75 MILLION FORS ALZHEIMER'S AND

691
00:26:44,675 --> 00:26:47,545
RELATED DEMENTIAS, IN CONCERT

692
00:26:47,545 --> 00:26:50,014
WITH NATIONAL INSTITUTE OF AGING

693
00:26:50,014 --> 00:26:53,117
MANAGE $300 MILLION A YEAR FOR

694
00:26:53,117 --> 00:26:55,052
ALZHEIMER'S DISEASE AND

695
00:26:55,052 --> 00:26:56,087
ALZHEIMER'S-RELATED DEMENTIA

696
00:26:56,087 --> 00:26:58,823
FUNDING, SOME FUNDS THAT CENTER

697
00:26:58,823 --> 00:27:00,858
IN THE INTRAMURAL PROGRAM.

698
00:27:00,858 --> 00:27:06,364
WE ALSO DIRECT THE UNDIAGNOSED 

699
00:27:06,364 --> 00:27:07,264
DISEASE NETWORK, AND RECEIVE $75

700
00:27:07,264 --> 00:27:10,067
MILLION UNDER THE ACT FOR ALS

701
00:27:10,067 --> 00:27:12,169
FOR PARTICULAR TYPES OF ALS

702
00:27:12,169 --> 00:27:14,572
RESEARCH. 

703
00:27:14,572 --> 00:27:17,074
SO WE'RE VERY BUSY HERE MANAGING

704
00:27:17,074 --> 00:27:20,678
WHAT WE THINK IS REALLY

705
00:27:20,678 --> 00:27:22,780
FANTASTIC PROGRAMS, AND HATS OFF

706
00:27:22,780 --> 00:27:26,384
TO OUR STAFF FOR TAKING UP ALL

707
00:27:26,384 --> 00:27:28,152
THESE EXTRA -- NOT QUITE EXTRA

708
00:27:28,152 --> 00:27:31,422
BUT ADDITIONAL WORK TO MAKE THE

709
00:27:31,422 --> 00:27:32,289
MOST OF THE TAXPAYERS'

710
00:27:32,289 --> 00:27:33,724
INVESTMENT IN NINDS.

711
00:27:33,724 --> 00:27:35,359
ON THIS SLIDE I DID WANT TO

712
00:27:35,359 --> 00:27:38,095
SHOW, WE'LL TALK ABOUT THIS IN A

713
00:27:38,095 --> 00:27:40,297
SECOND, THAT THERE IS A VERY

714
00:27:40,297 --> 00:27:41,132
SIGNIFICANT RISK THAT WE'RE

715
00:27:41,132 --> 00:27:43,434
WORRIED ABOUT WITH REGARD TO THE

716
00:27:43,434 --> 00:27:44,435
BRAIN INITIATIVE.

717
00:27:44,435 --> 00:27:46,303
THE BRAIN INITIATIVE MONEY CAME

718
00:27:46,303 --> 00:27:47,371
IN TWO BUCKETS.

719
00:27:47,371 --> 00:27:51,542
ONE CAME UNDER THE BASE, WHICH

720
00:27:51,542 --> 00:27:54,945
IS HERE ON THE ROW LABELED

721
00:27:54,945 --> 00:27:55,546
BRAIN, THE UNDER LABELED 21ST

722
00:27:55,546 --> 00:27:58,749
CENTURY CURES ACT MONEY.

723
00:27:58,749 --> 00:28:00,184
THE CURES ACT MONEY GOES UP AND

724
00:28:00,184 --> 00:28:01,819
DOWN EACH YEAR.

725
00:28:01,819 --> 00:28:04,855
THE BASE MONEY HAD BEEN GOING UP

726
00:28:04,855 --> 00:28:06,624
EACH YEAR UNTIL 2022.

727
00:28:06,624 --> 00:28:10,695
BUT IN 2023 THE CURES ACT MONEY

728
00:28:10,695 --> 00:28:12,863
WENT REALLY HIGH FROM $76

729
00:28:12,863 --> 00:28:15,399
MILLION TO $225 MILLION, AND TO

730
00:28:15,399 --> 00:28:18,135
KEEP OUR BUDGET FLAT THE BASE

731
00:28:18,135 --> 00:28:19,670
BUDGET FOR "BRAIN" TO THE

732
00:28:19,670 --> 00:28:23,074
INSTITUTES, A THAT'S US AND

733
00:28:23,074 --> 00:28:25,342
NIMH, WAS REDUCED TO $63 MILLION

734
00:28:25,342 --> 00:28:26,444
FROM $182 MILLION.

735
00:28:26,444 --> 00:28:28,979
AND THE PROBLEM GOING FORWARD IS

736
00:28:28,979 --> 00:28:30,948
THE HOUSE MARK DID NOT INCREASE

737
00:28:30,948 --> 00:28:35,119
THE BASE TO WHERE IT HAD BEEN

738
00:28:35,119 --> 00:28:38,189
PREVIOUSLY, AND THAT HAPPENS

739
00:28:38,189 --> 00:28:39,724
WHEN THE CURES MONEY DROPS

740
00:28:39,724 --> 00:28:40,591
SIGNIFICANTLY.

741
00:28:40,591 --> 00:28:41,826
SO THE BRAIN INITIATIVE, UNLESS

742
00:28:41,826 --> 00:28:46,297
THERE'S AN INCREASE TO THE BASE,

743
00:28:46,297 --> 00:28:48,699
WOULD BE CUT BY $278 MILLION IN

744
00:28:48,699 --> 00:28:50,501
24, WHICH OF COURSE WOULD BE

745
00:28:50,501 --> 00:28:52,236
CATASTROPHIC TO THEIR PROGRAMS.

746
00:28:52,236 --> 00:28:54,972
SOME OF WHICH WE'LL TALK ABOUT

747
00:28:54,972 --> 00:28:56,941
COMING UP.

748
00:28:56,941 --> 00:28:59,477
SO, NEXT SLIDE, WE'RE OPERATING

749
00:28:59,477 --> 00:29:02,313
UNDER DIFFERENT SCENARIOS OF A

750
00:29:02,313 --> 00:29:05,349
1% CUT OR POTENTIALLY 3 OR 5%

751
00:29:05,349 --> 00:29:06,350
CUT AS POSSIBILITIES.

752
00:29:06,350 --> 00:29:08,185
THIS IS OCCURRING IN THE CONTEXT

753
00:29:08,185 --> 00:29:09,520
OF INCREASING COSTS OF RESEARCH,

754
00:29:09,520 --> 00:29:12,590
AND THAT'S OF COURSE BECAUSE

755
00:29:12,590 --> 00:29:20,097
INFLATION HAS INCREASED THE 

756
00:29:20,097 --> 00:29:21,866
COST OF DOING RESEARCH,

757
00:29:21,866 --> 00:29:22,867
SALARIES, SUPPLIES, EQUIPMENT.

758
00:29:22,867 --> 00:29:25,569
THE BLACK LINE IS APPLICATIONS

759
00:29:25,569 --> 00:29:27,238
COMING IN, YEAR-TO-YEAR CHANGE

760
00:29:27,238 --> 00:29:28,873
IN COST.

761
00:29:28,873 --> 00:29:31,609
SO THE COSTS ARE GOING UP IN 24,

762
00:29:31,609 --> 00:29:34,979
THEY WENT UP BY ALMOST 13% OVER

763
00:29:34,979 --> 00:29:37,648
THE PRECEDING YEAR.

764
00:29:37,648 --> 00:29:39,150
THE AVERAGE REQUESTED COST OF

765
00:29:39,150 --> 00:29:42,453
GRANTS IS A LITTLE LESS STEEP

766
00:29:42,453 --> 00:29:45,389
BUT STILL GOING UP EACH YEAR.

767
00:29:45,389 --> 00:29:47,591
AND THE NUMBER OF COMPETING

768
00:29:47,591 --> 00:29:50,227
APPLICATIONS IS ALSO GOING UP.

769
00:29:50,227 --> 00:29:51,662
THE REASON IS THAT THERE'S BEEN

770
00:29:51,662 --> 00:29:56,100
AN INCREASE IN THE NUMBER OF

771
00:29:56,100 --> 00:29:57,568
NON-MODULAR GRANTS, BETWEEN 20

772
00:29:57,568 --> 00:30:01,172
AND 24 THERE WERE 800 ADDITIONAL

773
00:30:01,172 --> 00:30:02,106
APPLICATIONS FOR NON-MODULARS,

774
00:30:02,106 --> 00:30:03,340
MIRRORED BY DECREASE IN MODULAR

775
00:30:03,340 --> 00:30:06,076
GRANTS WHICH ARE THE LEAST

776
00:30:06,076 --> 00:30:07,745
EXPENSIVE GRANTS IN GENERAL, AND

777
00:30:07,745 --> 00:30:11,615
THERE WAS A DECREASE OF 460 OF

778
00:30:11,615 --> 00:30:15,519
THOSE BETWEEN 20 AND 24, ALSO AN

779
00:30:15,519 --> 00:30:16,587
INCREASE IN APPLICATIONS

780
00:30:16,587 --> 00:30:18,022
MULTI-P.I. GRANTS WHICH

781
00:30:18,022 --> 00:30:19,790
GENERALLY ARE MORE COSTLY.

782
00:30:19,790 --> 00:30:22,293
SO, THE TAKEHOME POINT HERE IS

783
00:30:22,293 --> 00:30:25,830
THAT IN A PERIOD, NEXT SLIDE,

784
00:30:25,830 --> 00:30:32,102
WHERE WE THINK THAT THERE WILL

785
00:30:32,102 --> 00:30:33,003
BE VYING PRIORITIES FOR

786
00:30:33,003 --> 00:30:34,772
NON-DISCRETIONAL FUNDS IN THE

787
00:30:34,772 --> 00:30:39,710
U.S. CONGRESS, WE HAVE TO REALLY

788
00:30:39,710 --> 00:30:42,646
PREPARE FOR POTENTIALLY, YOU

789
00:30:42,646 --> 00:30:44,415
KNOW, A FLAT OR HOPEFULLY NOT

790
00:30:44,415 --> 00:30:47,785
ANYTHING WORSE THAN A FLAT

791
00:30:47,785 --> 00:30:51,822
BUDGET IN 24, AND ALSO THE

792
00:30:51,822 --> 00:30:53,958
BUDGET DEAL INDICATES THAT 24

793
00:30:53,958 --> 00:30:57,294
WILL BE REFLECTED IN THE 25

794
00:30:57,294 --> 00:30:57,528
BUDGET.

795
00:30:57,528 --> 00:31:00,497
SO WE AT LEAST HAVE TO PREPARE

796
00:31:00,497 --> 00:31:03,467
FOR TWO YEARS OF THIS KIND OF

797
00:31:03,467 --> 00:31:04,201
MORE STRINGENT BUDGETING FROM

798
00:31:04,201 --> 00:31:07,805
CONGRESS, IN THE FACE OF THE

799
00:31:07,805 --> 00:31:09,240
INCREASING COSTS.

800
00:31:09,240 --> 00:31:09,807
NEXT SLIDE.

801
00:31:09,807 --> 00:31:12,076
SO, I THINK I WANTED TO JUST

802
00:31:12,076 --> 00:31:14,044
MENTION THE FACT THAT IT'S

803
00:31:14,044 --> 00:31:16,013
REALLY IMPORTANT AT THIS POINT

804
00:31:16,013 --> 00:31:17,581
IN TIME WITH ALL THESE BUYING

805
00:31:17,581 --> 00:31:18,983
PRIORITIES FOR CONGRESS THAT WE

806
00:31:18,983 --> 00:31:21,151
DO ACTUALLY MAKE A CASE FOR THE

807
00:31:21,151 --> 00:31:23,454
VALUE OF NIH RESEARCH, AND THIS

808
00:31:23,454 --> 00:31:26,824
IS JUST A PICTURE TO SHOW THAT

809
00:31:26,824 --> 00:31:28,926
THERE HAVE BEEN A NUMBER OF

810
00:31:28,926 --> 00:31:32,329
INSTANCES WHERE WE'VE BEEN

811
00:31:32,329 --> 00:31:33,397
INVITED TO CONGRESSIONAL

812
00:31:33,397 --> 00:31:33,731
BRIEFINGS.

813
00:31:33,731 --> 00:31:35,699
WE CANNOT CALL CONGRESS BUT IF

814
00:31:35,699 --> 00:31:37,368
INVITED WE ALWAYS SHOW UP.

815
00:31:37,368 --> 00:31:39,970
SO JUST WANTED TO MENTION THAT

816
00:31:39,970 --> 00:31:42,506
AND THANKS TO THE FOLKS THAT PUT

817
00:31:42,506 --> 00:31:46,110
TOGETHER THESE BRIEFINGS IN

818
00:31:46,110 --> 00:31:46,877
EPILEPSY, SPINAL MUSCULAR

819
00:31:46,877 --> 00:31:48,946
ATROPHY, BRAIN INITIATIVE AND

820
00:31:48,946 --> 00:31:51,115
HEAL INITIATIVE, BUT I ALSO WANT

821
00:31:51,115 --> 00:31:53,550
TO SAY THAT, YOU KNOW, MESSAGING

822
00:31:53,550 --> 00:31:55,419
THE VALUE OF NIH RESEARCH, THE

823
00:31:55,419 --> 00:31:57,821
GOVERNMENT CAN GO SO FAR,

824
00:31:57,821 --> 00:31:59,123
PROBABLY NOT VERY FAR, BUT

825
00:31:59,123 --> 00:32:02,960
REALLY THE PEOPLE DOING THE

826
00:32:02,960 --> 00:32:06,130
RESEARCH, THE UNIVERSITIES THAT

827
00:32:06,130 --> 00:32:06,931
ARE EMPLOYING RESEARCHERS I

828
00:32:06,931 --> 00:32:10,200
THINK SHOULD REALLY BE THINKING

829
00:32:10,200 --> 00:32:11,936
ABOUT JOINING IN THIS MESSAGING

830
00:32:11,936 --> 00:32:14,905
OF THE VALUE OF NIH RESEARCH.

831
00:32:14,905 --> 00:32:19,276
PARTICULARLY AT THIS POINT IN

832
00:32:19,276 --> 00:32:19,476
TIME.

833
00:32:19,476 --> 00:32:19,677
OKAY.

834
00:32:19,677 --> 00:32:20,477
NEXT SLIDE.

835
00:32:20,477 --> 00:32:22,579
I WANT TO REVISIT WHAT WE TALKED

836
00:32:22,579 --> 00:32:25,950
ABOUT AT THE LAST COUNCIL WITH

837
00:32:25,950 --> 00:32:29,453
REGARD TO OPTION FOR MORE

838
00:32:29,453 --> 00:32:30,187
STRINGENT BUDGET.

839
00:32:30,187 --> 00:32:30,921
DIVISION DIRECTORS GOT TOGETHER

840
00:32:30,921 --> 00:32:34,792
AND FORCED THEM TO COME UP WITH

841
00:32:34,792 --> 00:32:36,427
CUTS AND IDENTIFIED ABOUT $35

842
00:32:36,427 --> 00:32:40,497
MILLION IN CUTS OVER WHAT WAS

843
00:32:40,497 --> 00:32:43,434
PLANNED FOR 2024.

844
00:32:43,434 --> 00:32:46,737
WE ALSO ARE NOW FUNDING THE

845
00:32:46,737 --> 00:32:47,705
NON-COMPETING GRANTS, OUT-YEAR

846
00:32:47,705 --> 00:32:50,874
GRANTS, NOT BEING FULLY FUNDED,

847
00:32:50,874 --> 00:32:52,843
ONLY TO 90%, WHICH IS STANDARD

848
00:32:52,843 --> 00:32:55,179
FOR WHEN YOU'RE OPERATING UNDER

849
00:32:55,179 --> 00:32:56,146
CONTINUING RESOLUTION BECAUSE

850
00:32:56,146 --> 00:32:59,450
SHOULD YOU GET A BUDGET, SAY IN

851
00:32:59,450 --> 00:33:00,784
MARCH, LESS THAN THE CONTINUING

852
00:33:00,784 --> 00:33:03,187
RESOLUTION YOU WOULD NOT BE ABLE

853
00:33:03,187 --> 00:33:07,257
TO PAY ALL YOUR COMMITMENTS SO

854
00:33:07,257 --> 00:33:10,861
90% IS PAID NOW, 10% WITHHELD,

855
00:33:10,861 --> 00:33:13,364
HOPEFULLY WE CAN RESTORE THAT

856
00:33:13,364 --> 00:33:15,232
10% GOING FORWARD ONCE WE GET A

857
00:33:15,232 --> 00:33:15,566
BUDGET.

858
00:33:15,566 --> 00:33:17,301
BUT SHOULD WE GET A CUT IN OUR

859
00:33:17,301 --> 00:33:20,904
BUDGET WE'LL HAVE TO PASS THAT

860
00:33:20,904 --> 00:33:23,674
CUT ON TO SO THE TOTAL WILL NOT

861
00:33:23,674 --> 00:33:25,309
BE RESTORED AND THE AMOUNT

862
00:33:25,309 --> 00:33:28,345
RESTORED WILL DEPEND A LITTLE

863
00:33:28,345 --> 00:33:29,546
BIT ON -- ENTIRELY ON THE AMOUNT

864
00:33:29,546 --> 00:33:33,917
OF THE CUT TO OUR BUDGET.

865
00:33:33,917 --> 00:33:37,955
WE ARE CURRENTLY ALSO FUNDING

866
00:33:37,955 --> 00:33:39,823
THE NEW AWARDS WITH 20.5%

867
00:33:39,823 --> 00:33:42,126
ADMINISTRATIVE CUT, THIS IS A 3%

868
00:33:42,126 --> 00:33:43,227
INCREASE OVER STANDARD.

869
00:33:43,227 --> 00:33:46,497
AND FOR THE SAME REASON, AND WE

870
00:33:46,497 --> 00:33:48,365
MAY BE ABLE TO RESTORE THESE,

871
00:33:48,365 --> 00:33:51,168
DEPENDING WHAT THE BUDGET IS,

872
00:33:51,168 --> 00:33:53,070
BUT THAT STILL GIVES US THAT

873
00:33:53,070 --> 00:33:56,140
BUFFER AND WE ALSO HAD TO LOWER

874
00:33:56,140 --> 00:33:57,541
OUR PAY LINE TO 11 PERCENTILE.

875
00:33:57,541 --> 00:33:59,643
WE TALKED ABOUT A COUPLE THINGS

876
00:33:59,643 --> 00:34:02,679
GOING FORWARD THAT MIGHT HELP

877
00:34:02,679 --> 00:34:02,913
US.

878
00:34:02,913 --> 00:34:04,014
WE TALKED ABOUT LOWERING THE

879
00:34:04,014 --> 00:34:05,783
LEVEL WHICH GRANTS HAVE TO COME

880
00:34:05,783 --> 00:34:09,219
IN FOR PRE-APPROVAL TO COME IN,

881
00:34:09,219 --> 00:34:10,788
CURRENTLY AT $500,000, TURNS OUT

882
00:34:10,788 --> 00:34:14,124
WE CAN'T REALLY DO THAT ON OUR

883
00:34:14,124 --> 00:34:16,293
OWN AS AN INSTITUTE, HAS TO BE

884
00:34:16,293 --> 00:34:18,028
AN NIH POLICY CHANGE.

885
00:34:18,028 --> 00:34:20,697
WE TALKED ABOUT UPDATING THE SCR

886
00:34:20,697 --> 00:34:22,399
POLICY WHICH IS ON THE NEXT

887
00:34:22,399 --> 00:34:22,599
SLIDE.

888
00:34:22,599 --> 00:34:23,934
WE WILL DO THAT.

889
00:34:23,934 --> 00:34:26,570
WE TALKED ABOUT IMPLEMENTING A

890
00:34:26,570 --> 00:34:28,639
SPLIT PAYLINE, AND THE PROBLEM,

891
00:34:28,639 --> 00:34:30,074
DON'T GO YET.

892
00:34:30,074 --> 00:34:31,141
GO BACK.

893
00:34:31,141 --> 00:34:33,110
WE TALKED ABOUT IMPLEMENTING

894
00:34:33,110 --> 00:34:34,311
SPLIT PAYLINE, BUT THE TROUBLE

895
00:34:34,311 --> 00:34:39,016
WITH THAT HOW TO GET EQUITABLE

896
00:34:39,016 --> 00:34:42,086
DECISIONS MADE, GIVEN THE FACT

897
00:34:42,086 --> 00:34:44,855
THAT SOME TYPES OF RESEARCH IS

898
00:34:44,855 --> 00:34:46,457
INHERENTLY MORE EXPENSIVE THAN

899
00:34:46,457 --> 00:34:47,024
OTHERS.

900
00:34:47,024 --> 00:34:48,459
COUNCIL PUT UP A GREAT

901
00:34:48,459 --> 00:34:50,094
SUGGESTION WHICH IS TO INCREASE

902
00:34:50,094 --> 00:34:53,163
ADMIN CUTS TO APPLICATIONS OF

903
00:34:53,163 --> 00:34:54,231
HIGHER PERCENTILES.

904
00:34:54,231 --> 00:34:55,899
SO WE LOOKED CAREFULLY AT THAT.

905
00:34:55,899 --> 00:34:58,836
THE PROBLEM IS THAT IF WE'RE

906
00:34:58,836 --> 00:35:01,805
GOING TO ACTUALLY GENERATE THE

907
00:35:01,805 --> 00:35:05,542
FUNDS TO PAY HIGHER PERCENTILES

908
00:35:05,542 --> 00:35:06,710
BY CUTTING BETTER PERCENTILES,

909
00:35:06,710 --> 00:35:10,114
GIVEN THE FACT WE'RE ALREADY AT

910
00:35:10,114 --> 00:35:13,083
20.5% CUT, WE WOULD REALLY HAVE

911
00:35:13,083 --> 00:35:16,019
TO MAKE DRASTIC CUTS TO REALLY

912
00:35:16,019 --> 00:35:17,087
HIGH-SCORING GRANTS POTENTIALLY

913
00:35:17,087 --> 00:35:20,524
GOING DOWN TO THE SIXTH OR FIFTH

914
00:35:20,524 --> 00:35:21,825
PERCENTILE TO GENERATE THOSE

915
00:35:21,825 --> 00:35:22,793
KINDS OF FUNCTION.

916
00:35:22,793 --> 00:35:26,864
SO WE'RE HOLDING ON THAT AT THIS

917
00:35:26,864 --> 00:35:28,932
POINT IN TIME.

918
00:35:28,932 --> 00:35:29,833
NEXT SLIDE.

919
00:35:29,833 --> 00:35:31,468
IN TERMS OF THE SPECIAL COUNCIL

920
00:35:31,468 --> 00:35:36,039
REVIEW POLICY WE ARE MAKING A

921
00:35:36,039 --> 00:35:36,273
CHANGE.

922
00:35:36,273 --> 00:35:39,676
SO PEOPLE MAY RECALL THE SPECIAL

923
00:35:39,676 --> 00:35:42,379
COUNCIL REVIEW POLICY IS THAT

924
00:35:42,379 --> 00:35:48,652
NIH INSTITUTES HAVE TO LOOK AT

925
00:35:48,652 --> 00:35:50,287
GRANTS, GRANTEES, WHO HAVE OVER

926
00:35:50,287 --> 00:35:54,591
$2 MILLION IN TOTAL COSTS, IN

927
00:35:54,591 --> 00:35:56,093
THEIR NIH SUPPORT.

928
00:35:56,093 --> 00:35:59,396
AND WE HAVE THE ABILITY TO MAKE

929
00:35:59,396 --> 00:36:05,903
OUR OWN POLICY, WE'RE HOPING NOW

930
00:36:05,903 --> 00:36:08,505
TO REDUCE THAT TO $1.5 MILLION

931
00:36:08,505 --> 00:36:11,975
IN TOTAL COSTS, AND THIS IS

932
00:36:11,975 --> 00:36:13,210
EQUIVALENT TO $1 MILLION IN

933
00:36:13,210 --> 00:36:14,545
DIRECT COSTS.

934
00:36:14,545 --> 00:36:16,947
SO ANYONE COMING IN WITH GRANTS,

935
00:36:16,947 --> 00:36:18,248
AND THEY ALREADY HAVE, SAY, A

936
00:36:18,248 --> 00:36:21,318
MILLION DOLLARS IN DIRECT COSTS,

937
00:36:21,318 --> 00:36:24,621
THEY WILL BE -- THEY WILL HAVE

938
00:36:24,621 --> 00:36:29,126
TO ACHIEVE A GREATER PERCENTILE

939
00:36:29,126 --> 00:36:30,327
SCORE THAN THE OVERALL

940
00:36:30,327 --> 00:36:32,963
PERCENTILES OF PAYLINE TO GET

941
00:36:32,963 --> 00:36:33,564
FUNDED.

942
00:36:33,564 --> 00:36:36,800
SO CURRENTLY THE PAYLINE IS AT

943
00:36:36,800 --> 00:36:38,769
11 PERCENTILE SO IF SOMEONE

944
00:36:38,769 --> 00:36:41,605
MEETS THE SCR CRITERIA THEY WILL

945
00:36:41,605 --> 00:36:43,240
HAVE TO GET FIFTH PERCENTILE OR

946
00:36:43,240 --> 00:36:44,441
BETTER TO BE PAID.

947
00:36:44,441 --> 00:36:47,611
THERE ARE SOME EXCEPTIONS TO

948
00:36:47,611 --> 00:36:48,278
THOSE, PARTICULARLY IN THOSE

949
00:36:48,278 --> 00:36:50,581
AREAS THAT WHERE FUNDS ARE

950
00:36:50,581 --> 00:36:52,316
COMING TO THE INSTITUTE FOR

951
00:36:52,316 --> 00:36:54,718
PARTICULAR PURPOSES SO THOSE

952
00:36:54,718 --> 00:36:57,387
FUNDS WOULD NOT ACTUALLY HELP

953
00:36:57,387 --> 00:36:58,689
THE PAYLINE AT ALL.

954
00:36:58,689 --> 00:37:00,757
BUT THAT'S WHAT WE'RE DOING WITH

955
00:37:00,757 --> 00:37:04,361
SCR POLICY GOING TO A

956
00:37:04,361 --> 00:37:05,028
$1.5 MILLION TOTAL COST, IF YOU

957
00:37:05,028 --> 00:37:07,631
COME IN AND ALREADY HAVE THAT

958
00:37:07,631 --> 00:37:08,966
AMOUNT OF MONEY YOU'LL BE

959
00:37:08,966 --> 00:37:12,903
REQUIRED TO HIT THAT BETTER 

960
00:37:12,903 --> 00:37:13,237
PAYLINE.

961
00:37:13,237 --> 00:37:15,405
NEXT SLIDE.

962
00:37:15,405 --> 00:37:17,374
NEXT SLIDE JUST SHOWS PICTORIAL

963
00:37:17,374 --> 00:37:18,742
VIEW WHERE OUR MONEY GOES, YOU

964
00:37:18,742 --> 00:37:22,312
CAN SEE IN THE DARK BLUE THE

965
00:37:22,312 --> 00:37:28,218
MAJORITY OF OUR MONEY GOES OUT

966
00:37:28,218 --> 00:37:29,720
TO UNIVERSITIES, AND EXTRAMURAL

967
00:37:29,720 --> 00:37:30,621
GRANTS.

968
00:37:30,621 --> 00:37:33,023
LARGE MAJORITY OF THAT IS

969
00:37:33,023 --> 00:37:34,358
INVESTIGATOR INITIATED GRANTS.

970
00:37:34,358 --> 00:37:39,296
THEN YOU CAN SEE HERE IN LIGHTER

971
00:37:39,296 --> 00:37:41,898
BLUE, THE HEAL INITIATIVE MONEY,

972
00:37:41,898 --> 00:37:43,533
IN PURPLE INTRAMURAL PROGRAM,

973
00:37:43,533 --> 00:37:46,737
WHICH YOU'LL HEAR ABOUT FROM

974
00:37:46,737 --> 00:37:49,239
JEFF DIAMOND LATER TODAY.

975
00:37:49,239 --> 00:37:52,509
AND JUST TO MENTION THE IRP

976
00:37:52,509 --> 00:37:54,378
PROGRAM FUNDING IS NOT SIMPLY

977
00:37:54,378 --> 00:37:57,247
FOR THE SCIENCE BUT ALSO

978
00:37:57,247 --> 00:37:59,216
INCLUDES ABOUT 37% OF THAT MONEY

979
00:37:59,216 --> 00:38:00,517
REALLY TO SUPPORT THE

980
00:38:00,517 --> 00:38:03,320
INFRASTRUCTURE OF NIH IN

981
00:38:03,320 --> 00:38:03,553
GENERAL.

982
00:38:03,553 --> 00:38:05,188
AND THEN WE HAVE THE MONEY WE

983
00:38:05,188 --> 00:38:08,058
USE TO MANAGE IT AND PAY OUR

984
00:38:08,058 --> 00:38:08,258
STAFF.

985
00:38:08,258 --> 00:38:11,662
AND MONEY THAT GOES TO SBIR

986
00:38:11,662 --> 00:38:14,164
GRANTS, SMALL BUSINESS GRANTS,

987
00:38:14,164 --> 00:38:16,700
WHICH IS MANDATED BY CONGRESS.

988
00:38:16,700 --> 00:38:20,137
THEN YOU CAN SEE IN THE BRIGHT

989
00:38:20,137 --> 00:38:25,609
BLUE THE BRAIN INITIATIVE 

990
00:38:25,609 --> 00:38:25,842
FUNDING.

991
00:38:25,842 --> 00:38:28,412
AS MENTIONED $75 MILLION IN ALS

992
00:38:28,412 --> 00:38:29,880
FUNDING FOR EXPANDED ACCESS

993
00:38:29,880 --> 00:38:31,815
GRANTS AND RESEARCH IN THE

994
00:38:31,815 --> 00:38:32,949
PUBLIC -- FOR THE PUBLIC/PRIVATE

995
00:38:32,949 --> 00:38:35,452
PARTNERSHIP, WITH THE FDA FOR

996
00:38:35,452 --> 00:38:35,619
ALS.

997
00:38:35,619 --> 00:38:38,288
WE MANAGE, AGAIN, A LITTLE OVER

998
00:38:38,288 --> 00:38:42,125
$300 MILLION FOR THE AGING

999
00:38:42,125 --> 00:38:42,559
INSTITUTE.

1000
00:38:42,559 --> 00:38:44,294
OF THE AGENCY FUNDS FOR

1001
00:38:44,294 --> 00:38:46,363
ALZHEIMER'S DISEASE AND RELATED

1002
00:38:46,363 --> 00:38:46,630
DEMENTIAS.

1003
00:38:46,630 --> 00:38:48,031
NEXT SLIDE JUST TO MENTION

1004
00:38:48,031 --> 00:38:51,802
YOU'LL BE HEARING THIS AFTERNOON

1005
00:38:51,802 --> 00:38:53,603
FROM MIKE, AND LINDA PORTER,

1006
00:38:53,603 --> 00:38:58,775
ANNUAL REPORT OF THE HEAL

1007
00:38:58,775 --> 00:39:00,644
INITIATIVE, AND WE THANK THEM

1008
00:39:00,644 --> 00:39:01,945
FOR BEING WONDERFUL LEADERS, A

1009
00:39:01,945 --> 00:39:03,580
VERY AMBITIOUS PROGRAM.

1010
00:39:03,580 --> 00:39:06,316
NEXT SLIDE, THE PROGRAM HAS

1011
00:39:06,316 --> 00:39:12,089
UNDERGONE SOME CHANGES SINCE 

1012
00:39:12,089 --> 00:39:14,524
LAST WE MET, MAJOR CHANGES HEAL

1013
00:39:14,524 --> 00:39:20,097
GOVERNANCE MOVED OUT OF THE 

1014
00:39:20,097 --> 00:39:24,901
DIRECTOR'S OFFICE, NIH DIRECTOR 

1015
00:39:24,901 --> 00:39:28,405
NOW LED BY NATIONAL DRUG ABUSE

1016
00:39:28,405 --> 00:39:29,940
AND OUR INSTITUTE.

1017
00:39:29,940 --> 00:39:31,341
OUR INSTITUTE IS PRIMARILY

1018
00:39:31,341 --> 00:39:33,210
WORKING WITH NIDA ON

1019
00:39:33,210 --> 00:39:37,047
CROSS-CUTTING ISSUES BETWEEN

1020
00:39:37,047 --> 00:39:39,015
OPIOID OVERUSE AND PAIN

1021
00:39:39,015 --> 00:39:40,984
MANAGEMENT, HOW TO PREVENTED

1022
00:39:40,984 --> 00:39:42,185
OPIOID OVERUSE DISORDERS IN

1023
00:39:42,185 --> 00:39:43,920
FOLKS WHO HAVE CHRONIC PAIN AND

1024
00:39:43,920 --> 00:39:46,022
REQUIRE OPIOIDS AND HOW DO YOU

1025
00:39:46,022 --> 00:39:51,395
TREAT PAIN IN PEOPLE WHO HAVE

1026
00:39:51,395 --> 00:39:52,028
OPIOID USE DISORDER.

1027
00:39:52,028 --> 00:39:54,898
THE PAIN SIDE OF THINGS, WHICH

1028
00:39:54,898 --> 00:39:58,402
IS TO TRY AND DEVELOP NEW

1029
00:39:58,402 --> 00:39:59,302
NON-ADDICTIVE TREATMENTS FOR

1030
00:39:59,302 --> 00:40:02,672
PAIN, TO DEVELOP NEW MANAGEMENT

1031
00:40:02,672 --> 00:40:04,274
STRATEGIES FOR PAIN, REDUCING

1032
00:40:04,274 --> 00:40:05,776
THE RISK OF ADDICTION, LED BY A

1033
00:40:05,776 --> 00:40:06,643
BUNCH OF INSTITUTE.

1034
00:40:06,643 --> 00:40:09,813
WE'VE BEEN ABLE TO BROADEN THE

1035
00:40:09,813 --> 00:40:17,921
PROCESS AND INCLUDE 14  

1036
00:40:17,921 --> 00:40:18,555
INSTITUTES AND DIRECTORS MEETING

1037
00:40:18,555 --> 00:40:25,362
WITH REGARD TO THE PAIN SIDE OF

1038
00:40:25,362 --> 00:40:25,595
"HEAL."

1039
00:40:25,595 --> 00:40:27,230
OUR MISSION STATEMENT IS HERE,

1040
00:40:27,230 --> 00:40:28,665
REDUCE PAIN AND RISK OF OPIOID

1041
00:40:28,665 --> 00:40:30,066
USE DISORDER BY DEVELOPING SAFE

1042
00:40:30,066 --> 00:40:31,601
AND EFFECTIVE PAIN TREATMENT AND

1043
00:40:31,601 --> 00:40:33,904
PREVENTION STRATEGIES TO IMPROVE

1044
00:40:33,904 --> 00:40:39,142
QUALITY OF LIFE FOR ALL PEOPLE.

1045
00:40:39,142 --> 00:40:39,910
BESIDES THE CROSS-CUTTING

1046
00:40:39,910 --> 00:40:42,646
PROGRAMS, WE ALSO WILL BE

1047
00:40:42,646 --> 00:40:45,048
WORKING WITH NIDA AND THESE

1048
00:40:45,048 --> 00:40:46,683
INSTITUTES TO DEVELOP A "HEAL"

1049
00:40:46,683 --> 00:40:47,384
STRATEGIC PLAN, FOCUSING ON THE

1050
00:40:47,384 --> 00:40:50,654
PAIN SIDE OF THAT BUT ALSO ON

1051
00:40:50,654 --> 00:40:53,723
THE CROSS-CUTTING ISSUES.

1052
00:40:53,723 --> 00:40:55,525
AND THIS STRATEGIC PLAN HAS ALL

1053
00:40:55,525 --> 00:40:58,395
THOSE THAT WE DO HERE WILL BE A

1054
00:40:58,395 --> 00:41:00,497
WORKING GROUP FOR COUNCIL, SO

1055
00:41:00,497 --> 00:41:01,832
WONDERING IF ANYONE ON COUNCIL

1056
00:41:01,832 --> 00:41:03,433
IS INTERESTED IN WORKING ON THIS

1057
00:41:03,433 --> 00:41:04,434
SPACE TO DEVELOP STRATEGIC PLAN

1058
00:41:04,434 --> 00:41:05,969
LET US KNOW.

1059
00:41:05,969 --> 00:41:09,139
WE WILL ALSO BE REACHING OUT.

1060
00:41:09,139 --> 00:41:09,906
NEXT SLIDE.

1061
00:41:09,906 --> 00:41:12,075
I JUST WANT TO MENTION WE TALKED

1062
00:41:12,075 --> 00:41:13,510
ABOUT THE BUDGET PROBLEMS WITH

1063
00:41:13,510 --> 00:41:15,278
THE BRAIN INITIATIVE.

1064
00:41:15,278 --> 00:41:17,547
BUT THE REAL POSITIVE THINGS ARE

1065
00:41:17,547 --> 00:41:24,221
THAT THE BRAIN INITIATIVE HAS

1066
00:41:24,221 --> 00:41:25,455
EXCEEDED EXPECTATIONS AND

1067
00:41:25,455 --> 00:41:27,390
REVOLUTIONIZED OUR ABILITY TO

1068
00:41:27,390 --> 00:41:30,260
UNDERSTAND BRAIN CIRCUIT

1069
00:41:30,260 --> 00:41:31,995
INFORMATION PROCESSING.

1070
00:41:31,995 --> 00:41:36,066
THE GOAL WAS APPLY NEW TOOLS TO

1071
00:41:36,066 --> 00:41:39,135
UNDERSTAND HOW NEURAL CIRCUITS

1072
00:41:39,135 --> 00:41:40,203
UNDER LIE COMPLEX BEHAVIORS.

1073
00:41:40,203 --> 00:41:42,539
WE THOUGHT IT WAS GOING TO BE

1074
00:41:42,539 --> 00:41:45,375
GREAT BUT IT HAS EXCEEDED

1075
00:41:45,375 --> 00:41:46,243
EVERYONE'S EXPECTATIONS.

1076
00:41:46,243 --> 00:41:48,211
AND IT'S REALLY GETTING US TO

1077
00:41:48,211 --> 00:41:51,815
THE POINT WHERE WE CAN THINK

1078
00:41:51,815 --> 00:41:54,017
ABOUT DISEASES, ACTUALLY EVEN A

1079
00:41:54,017 --> 00:41:55,185
MUCH MORE SOPHISTICATED WAY

1080
00:41:55,185 --> 00:41:58,054
WHICH WE'LL COME TO IN A SECOND.

1081
00:41:58,054 --> 00:42:00,023
NEXT SLIDE AGAIN JUST EMPHASIZES

1082
00:42:00,023 --> 00:42:02,559
THE BUDGET ISSUE, AND THAT SHOWS

1083
00:42:02,559 --> 00:42:05,929
THAT THE IN LIGHT BLUE ON THE

1084
00:42:05,929 --> 00:42:07,664
NEXT SLIDE YOU'LL SEE THE CURES

1085
00:42:07,664 --> 00:42:09,866
MONEY, THE MAJORITY OF THE MONEY

1086
00:42:09,866 --> 00:42:11,768
IN FY 23, AND HOW THE BASE

1087
00:42:11,768 --> 00:42:14,037
BUDGET WHICH WAS THE DARK BLUE

1088
00:42:14,037 --> 00:42:17,974
GOT REDUCED IN 23, SO WE NEED

1089
00:42:17,974 --> 00:42:20,143
BECAUSE IN 24 THAT CURES MONEY

1090
00:42:20,143 --> 00:42:21,344
SUBSTANTIAL AMOUNT GOES AWAY, WE

1091
00:42:21,344 --> 00:42:22,979
REALLY NEED TO GET THAT BASE

1092
00:42:22,979 --> 00:42:29,452
BACK UP TO WHERE IT WAS BEFORE. 

1093
00:42:29,452 --> 00:42:29,886
NEXT SLIDE.

1094
00:42:29,886 --> 00:42:37,327
BUT  THE BRAIN ADVANCES ARE

1095
00:42:37,327 --> 00:42:38,295
SPECTACULAR, RECENTLY MULTIPLE

1096
00:42:38,295 --> 00:42:40,263
ARTICLES PUBLISHED TODAY IN

1097
00:42:40,263 --> 00:42:41,064
NATURE, SCIENCE, SCIENCE

1098
00:42:41,064 --> 00:42:44,234
ADVANCES ON A CELL CENSUS AND

1099
00:42:44,234 --> 00:42:46,736
BRAIN MAPS, AND SO JUST THE

1100
00:42:46,736 --> 00:42:47,404
BASICALLY SIMPLIFY WHAT THE

1101
00:42:47,404 --> 00:42:49,039
BRAIN INITIATIVE HAS DONE SO FAR

1102
00:42:49,039 --> 00:42:51,141
IS DEVELOP WHAT WE CALL A CELL

1103
00:42:51,141 --> 00:42:54,511
ATLAS OR CELL CENSUS OF ALL THE

1104
00:42:54,511 --> 00:42:55,478
CELLS IN THE BRAIN.

1105
00:42:55,478 --> 00:42:59,649
AND THIS IS BASED ON A NUMBER OF

1106
00:42:59,649 --> 00:43:00,417
DIFFERENT CHARACTERIZATIONS BUT

1107
00:43:00,417 --> 00:43:02,385
PRIMARILY HIGH-THROUGHPUT METHOD

1108
00:43:02,385 --> 00:43:06,189
OF LOOKING AT THE RNA AND OPEN

1109
00:43:06,189 --> 00:43:10,260
CHROMATIN IN THE DIFFERENT CELL 

1110
00:43:10,260 --> 00:43:11,461
TYPES, AND THAT ACTUALLY

1111
00:43:11,461 --> 00:43:14,764
GENERATES A LIBRARY OF DIFFERENT

1112
00:43:14,764 --> 00:43:17,934
CELL TYPES, BUT ALSO MORE THAN

1113
00:43:17,934 --> 00:43:19,669
THAT IT ALLOWS YOU GENETIC TOOLS

1114
00:43:19,669 --> 00:43:22,305
TO GO IN AND THEN STUDY THE

1115
00:43:22,305 --> 00:43:24,274
CONNECTIONS BETWEEN THOSE

1116
00:43:24,274 --> 00:43:25,141
DIFFERENT CELLS, TO IDENTIFY

1117
00:43:25,141 --> 00:43:28,078
DIFFERENT CELL TYPES AND THEN

1118
00:43:28,078 --> 00:43:30,380
LOOK AT ELECTROPHYSIOLOGICAL

1119
00:43:30,380 --> 00:43:31,214
PROPERTIES, MOST IMPORTANTLY

1120
00:43:31,214 --> 00:43:33,883
GIVES YOU GENETIC KEYS TO GET

1121
00:43:33,883 --> 00:43:35,518
PRECISE ACCESS TO PARTICULAR

1122
00:43:35,518 --> 00:43:36,319
CELL TYPES.

1123
00:43:36,319 --> 00:43:39,990
AND THAT ALLOWS YOU TO MONITOR

1124
00:43:39,990 --> 00:43:42,993
CELLS, THEIR ACTIVITY, ALL SORTS

1125
00:43:42,993 --> 00:43:46,062
OF BEHAVIORS, AND MOST

1126
00:43:46,062 --> 00:43:48,665
IMPORTANTLY FOR DISEASES

1127
00:43:48,665 --> 00:43:49,432
MODULATE BEHAVIOR OF DIFFERENT

1128
00:43:49,432 --> 00:43:49,699
CIRCUITS.

1129
00:43:49,699 --> 00:43:55,438
ALMOST ALL OF OUR DISEASES CAUSE

1130
00:43:55,438 --> 00:43:56,673
PROBLEMS BECAUSE THEY AFFECT

1131
00:43:56,673 --> 00:43:58,642
ACTUAL FUNCTION OF CIRCUITS.

1132
00:43:58,642 --> 00:44:03,146
THE NEXT SLIDE IS AN EXAMPLE

1133
00:44:03,146 --> 00:44:07,817
WHAT IS HAPPENING, AND YOU CAN

1134
00:44:07,817 --> 00:44:10,654
START THE MOVIE.

1135
00:44:10,654 --> 00:44:14,591
IS USING REALLY THE TECHNOLOGIES

1136
00:44:14,591 --> 00:44:16,793
OF ELECTRICAL STIMULATION, THE

1137
00:44:16,793 --> 00:44:18,728
BRAIN INITIATIVE TECHNOLOGIES

1138
00:44:18,728 --> 00:44:21,264
ARE GOING TO BE MORE

1139
00:44:21,264 --> 00:44:22,298
SOPHISTICATE AND PRECISE.

1140
00:44:22,298 --> 00:44:24,434
IN THIS STUDY THEY ARE

1141
00:44:24,434 --> 00:44:26,169
STIMULATING SENSORY ROOTS TO

1142
00:44:26,169 --> 00:44:27,604
CERVICAL MUSCLES THAT MOVE THE

1143
00:44:27,604 --> 00:44:28,271
ARM.

1144
00:44:28,271 --> 00:44:30,573
A PERSON WHO HAD A STROKE.

1145
00:44:30,573 --> 00:44:35,278
HERE YOU CAN SEE BEFORE TURNED

1146
00:44:35,278 --> 00:44:36,713
ON HOW MUCH DIFFICULTY THIS

1147
00:44:36,713 --> 00:44:38,882
YOUNG WOMAN IS HAVING WITH THE

1148
00:44:38,882 --> 00:44:41,384
LEFT HAND AS SHE TRIES TO STAB

1149
00:44:41,384 --> 00:44:44,120
FOOD TO BRING TO HER MOUTH TO

1150
00:44:44,120 --> 00:44:45,221
EAT.

1151
00:44:45,221 --> 00:44:47,857
AND SO JUST TO KNOW THAT OFTEN

1152
00:44:47,857 --> 00:44:48,958
TIMES WEAKNESS IS NOT

1153
00:44:48,958 --> 00:44:50,160
NECESSARILY THE BIGGEST PROBLEM,

1154
00:44:50,160 --> 00:44:53,430
BUT THE PROBLEM IS MOTOR CONTROL

1155
00:44:53,430 --> 00:44:55,165
THAT IS SO DISABLED WHEN PEOPLE

1156
00:44:55,165 --> 00:44:59,135
HAVE STROKE OR OTHER NEURAL

1157
00:44:59,135 --> 00:44:59,369
INJURY.

1158
00:44:59,369 --> 00:45:00,336
BUT YOU'LL SEE SHE'S TRYING TO

1159
00:45:00,336 --> 00:45:01,971
GET IT IN.

1160
00:45:01,971 --> 00:45:05,375
SHE HAS TO TIP HER BODY OVER.

1161
00:45:05,375 --> 00:45:07,911
YOU TURN THE STIMULATOR ON AND

1162
00:45:07,911 --> 00:45:09,746
YOU IS SEE HOW MUCH MORE FACILE

1163
00:45:09,746 --> 00:45:11,948
SHE IS WITH HER HANDS.

1164
00:45:11,948 --> 00:45:13,483
THERE ARE STUDIES THAT LOOK AT

1165
00:45:13,483 --> 00:45:14,784
HOW THIS IS ACTUALLY HAPPENING

1166
00:45:14,784 --> 00:45:19,923
USING THE BRAIN INITIATIVE

1167
00:45:19,923 --> 00:45:20,256
TOOLS.

1168
00:45:20,256 --> 00:45:21,758
THE OTHER POINT, STUDY FUNDED BY

1169
00:45:21,758 --> 00:45:24,728
THE BRAIN INITIATIVE, YOU CAN

1170
00:45:24,728 --> 00:45:26,796
SEE ALMOST AS AMAZING IF NOT

1171
00:45:26,796 --> 00:45:28,231
MORE AMAZING RESULTS IN THE SAME

1172
00:45:28,231 --> 00:45:30,734
TYPE OF STIMULATION OF THESE

1173
00:45:30,734 --> 00:45:32,502
SENSORY ROOTS, PEOPLE WITH

1174
00:45:32,502 --> 00:45:33,269
SPINAL CORD INJURY, ALLOWING

1175
00:45:33,269 --> 00:45:36,439
THEM TO WALK WHEN THEY COULDN'T

1176
00:45:36,439 --> 00:45:39,375
WALK BEFORE, AND REMARKABLY

1177
00:45:39,375 --> 00:45:40,376
PEOPLE WITH PARKINSON'S DISEASE

1178
00:45:40,376 --> 00:45:41,311
WITH SEVERE GAIT DISORDER BUT

1179
00:45:41,311 --> 00:45:42,645
WITH THE SAME KIND OF

1180
00:45:42,645 --> 00:45:50,120
STIMULATION HAVE ALMOST A

1181
00:45:50,120 --> 00:45:50,553
NORMAL-LOOKING GAIT.

1182
00:45:50,553 --> 00:45:52,055
THEY FOUND A WAY TO ENGAGE

1183
00:45:52,055 --> 00:45:55,825
NEURAL CIRCUITS AT SPINAL CORD

1184
00:45:55,825 --> 00:45:57,227
LEVEL, ALLOW THEM TO BE MORE

1185
00:45:57,227 --> 00:45:58,795
CLOSELY TIED IN TO INPUTS COMING

1186
00:45:58,795 --> 00:46:01,965
FROM ABOVE.

1187
00:46:01,965 --> 00:46:05,668
THIS IS NOT -- THIS IS VOLUNTARY

1188
00:46:05,668 --> 00:46:07,103
MOVEMENT, NOT AUTOMATIC

1189
00:46:07,103 --> 00:46:08,304
MOVEMENT.

1190
00:46:08,304 --> 00:46:13,009
THIS IS IMPROVED ABILITY TO MAKE

1191
00:46:13,009 --> 00:46:13,676
VOLUNTARY MOVEMENTS, NOT

1192
00:46:13,676 --> 00:46:15,211
SOMETHING ANYBODY COULD HAVE

1193
00:46:15,211 --> 00:46:15,612
GUESSED.

1194
00:46:15,612 --> 00:46:16,613
THAT'S THE MESSAGE FROM THE

1195
00:46:16,613 --> 00:46:17,380
BRAIN INITIATIVE, YOU KNOW THERE

1196
00:46:17,380 --> 00:46:22,652
ARE GOING TO BE JUST AMAZING

1197
00:46:22,652 --> 00:46:23,386
THERAPEUTIC AND DIAGNOSTIC

1198
00:46:23,386 --> 00:46:26,256
RESULTS THAT ARE GOING TO CHANGE

1199
00:46:26,256 --> 00:46:28,558
HOW WE PRACTICE NEUROLOGY AND

1200
00:46:28,558 --> 00:46:30,193
PROBABLY EVEN MORE SO

1201
00:46:30,193 --> 00:46:30,493
PSYCHIATRY.

1202
00:46:30,493 --> 00:46:32,162
THE BRAIN INITIATIVE, AT THE

1203
00:46:32,162 --> 00:46:36,766
"HEAL" MEETING WE JUST HAD

1204
00:46:36,766 --> 00:46:37,801
PRESENTATIONS BY FOLKS

1205
00:46:37,801 --> 00:46:39,936
STIMULATING INSIDE THE BRAIN TO

1206
00:46:39,936 --> 00:46:42,972
REDUCE CRAVING IN PEOPLE WITH

1207
00:46:42,972 --> 00:46:44,641
OVERUSE DISORDER, AND IS A

1208
00:46:44,641 --> 00:46:46,943
GENTLEMAN WHO HAD SEVERE CHRONIC

1209
00:46:46,943 --> 00:46:48,711
PAIN AND IN STUDIES FUNDED BY

1210
00:46:48,711 --> 00:46:51,314
"HEAL" AND "BRAIN" HAD A CLOSED

1211
00:46:51,314 --> 00:46:55,251
LOOP STIMULATOR PUT IN, AND HIS

1212
00:46:55,251 --> 00:46:56,553
PAIN MIRACULOUSLY JUST

1213
00:46:56,553 --> 00:46:56,953
DISAPPEARED.

1214
00:46:56,953 --> 00:47:01,024
SO REALLY AMAZING STUFF COMING

1215
00:47:01,024 --> 00:47:02,058
OUT FROM THESE INITIATIVES.

1216
00:47:02,058 --> 00:47:04,928
NEXT SLIDE, I'M GOING TO MOVE TO

1217
00:47:04,928 --> 00:47:06,629
POLICY PAPERS THAT HAVE COME OUT

1218
00:47:06,629 --> 00:47:08,498
FROM THE ADVISORY COMMITTEE TO

1219
00:47:08,498 --> 00:47:11,134
THE DIRECTOR OF NIH.

1220
00:47:11,134 --> 00:47:13,203
AND THIS IS ABOUT THE POSTDOC

1221
00:47:13,203 --> 00:47:15,705
SITUATION IN THE COUNTRY, THE

1222
00:47:15,705 --> 00:47:16,906
WORKING GROUP REPORT, AND THEY

1223
00:47:16,906 --> 00:47:19,542
HAD A NUMBER OF RECOMMENDATIONS.

1224
00:47:19,542 --> 00:47:22,378
SO PEOPLE WHO ARE NOT AWARE IN

1225
00:47:22,378 --> 00:47:23,580
THE UNITED STATES AND THIS IS A

1226
00:47:23,580 --> 00:47:27,784
LITTLE BIT OF A SIMPLIFICATION,

1227
00:47:27,784 --> 00:47:30,053
WE FUND INVESTIGATORS TO DO

1228
00:47:30,053 --> 00:47:31,454
GRANT RESEARCH ON GRANTS, THE

1229
00:47:31,454 --> 00:47:38,027
WORK IS OFTEN DONE BY WHAT'S

1230
00:47:38,027 --> 00:47:41,965
CALLED POSTBACS, PEOPLE IN

1231
00:47:41,965 --> 00:47:47,437
TRAINING PRIOR TO BECOMING A

1232
00:47:47,437 --> 00:47:48,404
PRINCIPAL INVESTIGATOR OR PhD

1233
00:47:48,404 --> 00:47:50,306
student.

1234
00:47:50,306 --> 00:47:55,144
THEY ARE IN A PECULIAR POSITION,

1235
00:47:55,144 --> 00:47:56,779
NOT STAFF MEMBERS, SO ADVANCED

1236
00:47:56,779 --> 00:47:59,048
IT'S PRETTY HARD TO CALL THEM

1237
00:47:59,048 --> 00:47:59,816
TRAINEES ANYMORE.

1238
00:47:59,816 --> 00:48:00,783
SO, THAT'S WHAT WE'RE DEALING

1239
00:48:00,783 --> 00:48:02,118
WITH HERE.

1240
00:48:02,118 --> 00:48:03,186
AND THE RECOMMENDATIONS ARE

1241
00:48:03,186 --> 00:48:06,356
INCREASE THE PAY AND BENEFITS

1242
00:48:06,356 --> 00:48:09,025
AND TREAT THEM AS STAFF MEMBERS.

1243
00:48:09,025 --> 00:48:13,096
AND TO EXPAND THE MECHANISM TO

1244
00:48:13,096 --> 00:48:15,231
SUPPORT FULL TALENT POOL OF

1245
00:48:15,231 --> 00:48:16,799
POSTBAC SCHOLARS.

1246
00:48:16,799 --> 00:48:19,402
ONE BIG PROBLEM IN THE U.S.

1247
00:48:19,402 --> 00:48:21,170
GRANTS WE HAVE TO SUPPORT

1248
00:48:21,170 --> 00:48:22,338
POSTBACS UNDER TRAINING GRANTS

1249
00:48:22,338 --> 00:48:23,306
ARE NOT AVAILABLE FOR THOSE

1250
00:48:23,306 --> 00:48:27,710
UNLESS YOU HAVE A GREEN CARD OR

1251
00:48:27,710 --> 00:48:30,647
U.S. CITIZEN AND YET WE BENEFIT

1252
00:48:30,647 --> 00:48:33,416
SO TREMENDOUSLY BY BRINGING IN

1253
00:48:33,416 --> 00:48:34,684
TRAINEES FROM FOREIGN COUNTRIES.

1254
00:48:34,684 --> 00:48:37,320
NEXT SLIDE SHOWS A COUPLE OTHER

1255
00:48:37,320 --> 00:48:39,722
RECOMMENDATIONS, AND THESE

1256
00:48:39,722 --> 00:48:41,591
INVOLVE PUTTING MORE EMPHASIS ON

1257
00:48:41,591 --> 00:48:43,493
THE ACTUAL CLIMATE AND ECOSYSTEM

1258
00:48:43,493 --> 00:48:48,698
WHICH THE POSTDOCS ARE WORKING.

1259
00:48:48,698 --> 00:48:50,333
SO TO FACILITATE TRANSITION OF

1260
00:48:50,333 --> 00:48:52,969
SCHOLARS TO THE NEXT CAREER

1261
00:48:52,969 --> 00:48:54,504
STAGE INCLUDING ROLES BEYOND

1262
00:48:54,504 --> 00:48:58,041
ACADEMIC FACULTY, PROMOTE THE 

1263
00:48:58,041 --> 00:49:01,978
TRAINING AND PROFESSIONAL

1264
00:49:01,978 --> 00:49:02,412
DEVELOPMENT.

1265
00:49:02,412 --> 00:49:04,614
POSTDOC SCHOLARS, A TO SUPPORT A

1266
00:49:04,614 --> 00:49:06,015
SAFE AND HEALTHY ENVIRONMENT TO

1267
00:49:06,015 --> 00:49:08,117
DEVELOP PROJECTS SO IMPORTANT TO

1268
00:49:08,117 --> 00:49:12,055
NIH AND THEN TO DEVELOP THE

1269
00:49:12,055 --> 00:49:15,525
EXPERTISE AND EXPERIENCE TO

1270
00:49:15,525 --> 00:49:17,527
BECOME INDEPENDENT

1271
00:49:17,527 --> 00:49:18,628
INVESTIGATORS.

1272
00:49:18,628 --> 00:49:19,729
NEXT SLIDE.

1273
00:49:19,729 --> 00:49:21,798
THE NEXT REPORT TO THE DIRECTOR

1274
00:49:21,798 --> 00:49:24,701
THAT I WANTED TO MENTION IS

1275
00:49:24,701 --> 00:49:27,370
AROUND THE USE OF NOVEL

1276
00:49:27,370 --> 00:49:28,705
ALTERNATIVE METHODS AND NEW

1277
00:49:28,705 --> 00:49:31,207
COMMON FUND PROGRAM RELATED TO

1278
00:49:31,207 --> 00:49:31,407
THIS.

1279
00:49:31,407 --> 00:49:32,508
SO, JUST RECENTLY I DON'T KNOW

1280
00:49:32,508 --> 00:49:36,112
IF PEOPLE SAW IT BUT IN SCIENCE

1281
00:49:36,112 --> 00:49:37,880
TRANSLATIONAL MEDICINE THERE WAS

1282
00:49:37,880 --> 00:49:41,684
AN NINDS-FUNDED STUDY THAT CAME

1283
00:49:41,684 --> 00:49:49,125
OUT USING 3D PRINTING TO DEVELOP

1284
00:49:49,125 --> 00:49:52,528
CORTICAL STRIATAL iPS CELLS IN

1285
00:49:52,528 --> 00:49:53,863
A GEL MATRIX.

1286
00:49:53,863 --> 00:49:55,965
AND THIS IS AN EXAMPLE OF THESE

1287
00:49:55,965 --> 00:49:57,600
KINDS OF ALTERNATIVE METHODS IN

1288
00:49:57,600 --> 00:49:59,469
WHICH YOU CAN STUDY INTERACTION

1289
00:49:59,469 --> 00:50:00,536
BETWEEN DIFFERENT CELL TYPES.

1290
00:50:00,536 --> 00:50:04,307
THEY HAVE NEURONS. 

1291
00:50:04,307 --> 00:50:05,475
THEY HAVE GLIA.

1292
00:50:05,475 --> 00:50:09,212
AND THE IDEA HERE IS THAT WE

1293
00:50:09,212 --> 00:50:12,181
COULD ACTUALLY LEARN MORE FROM

1294
00:50:12,181 --> 00:50:13,616
MANY OF THESE COMPLEMENTARY

1295
00:50:13,616 --> 00:50:14,250
METHODS, NOT ALTERNATIVE

1296
00:50:14,250 --> 00:50:16,552
METHODS, TO THE ANIMAL

1297
00:50:16,552 --> 00:50:17,754
EXPERIMENTS BUT POTENTIALLY

1298
00:50:17,754 --> 00:50:18,688
COMPLEMENTARY.

1299
00:50:18,688 --> 00:50:21,057
I WOULD SAY THERE'S A LOT OF

1300
00:50:21,057 --> 00:50:22,792
HYPE AROUND THIS, AND JUST WITH

1301
00:50:22,792 --> 00:50:25,628
REGARD TO THIS SCIENCE HAS A

1302
00:50:25,628 --> 00:50:27,864
COMMENTARY ABOUT THE ARTICLE,

1303
00:50:27,864 --> 00:50:31,234
WHICH THEY ENTITLED 3D PRINTER

1304
00:50:31,234 --> 00:50:32,168
CREATES BRAIN TISSUE THAT ACTS

1305
00:50:32,168 --> 00:50:36,939
LIKE THE REAL THING, WHICH IS

1306
00:50:36,939 --> 00:50:39,308
NOT TRUE.

1307
00:50:39,308 --> 00:50:41,110
DEPENDING HOW YOU DEFINE "ACTS"

1308
00:50:41,110 --> 00:50:44,480
BUT NOT IN THE BIG PICTURE OF

1309
00:50:44,480 --> 00:50:46,549
HOW CIRCUITS ARE WORKING.

1310
00:50:46,549 --> 00:50:48,418
WE HAVE TO BE CAREFUL TO STRESS

1311
00:50:48,418 --> 00:50:51,487
THESE ARE COMPLEMENTARY AND NOT

1312
00:50:51,487 --> 00:50:52,455
ALTERNATIVES.

1313
00:50:52,455 --> 00:50:55,191
BUT THERE IS A COMMON FUND

1314
00:50:55,191 --> 00:50:56,426
PROJECT DECIDED BY DR.

1315
00:50:56,426 --> 00:50:57,493
BERTAGNOLLI TO GO AHEAD.

1316
00:50:57,493 --> 00:51:00,830
AND THIS IS DEVELOP MORE OF

1317
00:51:00,830 --> 00:51:06,469
THESE MODELS AND THIS IS FUNDED 

1318
00:51:06,469 --> 00:51:08,104
TO ABOUT $35 MILLION TO $40

1319
00:51:08,104 --> 00:51:10,306
MILLION A YEAR, NOT LAUNCHED YET

1320
00:51:10,306 --> 00:51:14,577
IN TERMS OF ACTUAL PROGRAMS BUT

1321
00:51:14,577 --> 00:51:18,381
OUR NINDS FOLKS, SARAH, JULIA,

1322
00:51:18,381 --> 00:51:20,016
JOE AND GRACE ARE WORKING ON

1323
00:51:20,016 --> 00:51:21,184
THIS GOING FORWARD.

1324
00:51:21,184 --> 00:51:23,619
NEXT SLIDE, GREAT WORK THAT THE

1325
00:51:23,619 --> 00:51:26,956
FUNDAMENTAL NEUROSCIENCE WORKING

1326
00:51:26,956 --> 00:51:27,590
GROUP DID.

1327
00:51:27,590 --> 00:51:30,093
AND REPORT TO COUNCIL WAS

1328
00:51:30,093 --> 00:51:37,667
APPROVED AT OUR LAST COUNCIL. 

1329
00:51:37,667 --> 00:51:38,768
THE SIX MOST SALIENT

1330
00:51:38,768 --> 00:51:41,704
RECOMMENDATIONS ARE ON THIS

1331
00:51:41,704 --> 00:51:41,938
SLIDE.

1332
00:51:41,938 --> 00:51:44,440
WE'RE PURSUING HOW TO MOVE THIS

1333
00:51:44,440 --> 00:51:45,541
FORWARD.

1334
00:51:45,541 --> 00:51:47,043
RIGHT NOW WE'RE PUTTING TOES IN

1335
00:51:47,043 --> 00:51:49,512
THE WATER CONVENING A WORKSHOP,

1336
00:51:49,512 --> 00:51:53,216
IDENTIFYING COLLABORATIVE

1337
00:51:53,216 --> 00:51:53,983
INTERACTIONS, ENCOURAGING

1338
00:51:53,983 --> 00:51:55,718
COLLABORATIVE RESEARCH, THINKING

1339
00:51:55,718 --> 00:51:58,387
OF MOVING THE TEAM SCIENCE

1340
00:51:58,387 --> 00:52:00,022
RECOMMENDATION INTO OUR R01

1341
00:52:00,022 --> 00:52:01,324
PROGRAM.

1342
00:52:01,324 --> 00:52:02,625
SO I WANT TO AGAIN THANKS, AND

1343
00:52:02,625 --> 00:52:04,927
YOU HAVEN'T SEEN THE LAST OF

1344
00:52:04,927 --> 00:52:05,261
THIS.

1345
00:52:05,261 --> 00:52:06,796
WE'RE WORKING HARD, WE THINK

1346
00:52:06,796 --> 00:52:09,699
THIS IS VERY IMPORTANT.

1347
00:52:09,699 --> 00:52:11,701
NEXT SLIDE.

1348
00:52:11,701 --> 00:52:13,569
I WANTED TO MENTION THERE'S A

1349
00:52:13,569 --> 00:52:16,639
WORKING GROUP OF COUNCIL ENGAGED

1350
00:52:16,639 --> 00:52:24,947
IN DEVELOPING A ROADMAP FOR A

1351
00:52:24,947 --> 00:52:30,306
MYALGIC SYNDROME, MECF RESEARCH,

1352
00:52:30,306 --> 00:52:32,708
CALL FOR PUBLIC INPUT WHICH IS

1353
00:52:32,708 --> 00:52:35,144
DUE BY MARCH 28 SO I ASK PEOPLE

1354
00:52:35,144 --> 00:52:37,313
TO USE THAT LINK IF THEY HAVE

1355
00:52:37,313 --> 00:52:39,181
INPUT ON WHAT THEY FEEL ARE THE

1356
00:52:39,181 --> 00:52:46,455
TOP PRIORITIES IN THIS S PACE.

1357
00:52:46,455 --> 00:52:48,757
NEXT SLIDE.

1358
00:52:48,757 --> 00:52:52,828
NEXT, A HAPPY SLIDE, FORENINDS A

1359
00:52:52,828 --> 00:52:53,929
HAPPY SLIDE.

1360
00:52:53,929 --> 00:52:56,632
FOR ME TURNING 75 WOULD NOT BE

1361
00:52:56,632 --> 00:52:59,702
SO HAPPY BUT NINDS TURNED 75 IN

1362
00:52:59,702 --> 00:52:59,902
2025.

1363
00:52:59,902 --> 00:53:09,011
WE HAVE A LOT TO BE PROUD OF.

1364
00:53:09,011 --> 00:53:10,646
WE'RE LOOKING, ALISSA WILL TALK

1365
00:53:10,646 --> 00:53:12,181
TO YOU THIS AFTERNOON WHAT WE

1366
00:53:12,181 --> 00:53:13,816
CAN DO TO CELEBRATE AND USE THIS

1367
00:53:13,816 --> 00:53:16,518
OPPORTUNITY TO THINK HOW WE CAN

1368
00:53:16,518 --> 00:53:19,188
BE MORE EFFECTIVE IN THE FUTURE

1369
00:53:19,188 --> 00:53:20,823
IN ACHIEVING OUR MISSION.

1370
00:53:20,823 --> 00:53:22,591
WE LOOK FORWARD TO HER

1371
00:53:22,591 --> 00:53:24,994
PRESENTATION AND YOUR DISCUSSION

1372
00:53:24,994 --> 00:53:29,531
THIS AFTERNOON.

1373
00:53:29,531 --> 00:53:32,034
AND NEXT SLIDE.

1374
00:53:32,034 --> 00:53:34,536
NEXT SLIDE ILLUSTRATES THE

1375
00:53:34,536 --> 00:53:37,172
ACTIVITIES THAT WE INVOLVE IN

1376
00:53:37,172 --> 00:53:39,608
USING OUR CONVENING POWERS,

1377
00:53:39,608 --> 00:53:40,876
MULTIPLE DIFFERENT MEETINGS IN

1378
00:53:40,876 --> 00:53:42,845
DIFFERENT AREAS OF SCIENCE,

1379
00:53:42,845 --> 00:53:43,746
BRINGING TOGETHER INVESTIGATORS

1380
00:53:43,746 --> 00:53:46,949
AND THIS IS HOW WE LEARN AS AN

1381
00:53:46,949 --> 00:53:53,022
INSTITUTE BUT ALSO I THINK WE

1382
00:53:53,022 --> 00:53:54,323
CAN PROVIDE A GREAT SERVICE TO

1383
00:53:54,323 --> 00:53:55,991
THE COMMUNITY GETTING THEIR

1384
00:53:55,991 --> 00:53:57,059
TOPICS DISCUSSED.

1385
00:53:57,059 --> 00:53:58,927
TAKE A LOOK AT THOSE.

1386
00:53:58,927 --> 00:54:00,696
WE'LL HAVE REPORTS COMING OUT

1387
00:54:00,696 --> 00:54:04,500
FOR THE RECENT ONES THAT ARE

1388
00:54:04,500 --> 00:54:11,073
OVER AND UPCOMING ONES PLEASE 

1389
00:54:11,073 --> 00:54:12,307
JOIN IF YOU CAN.

1390
00:54:12,307 --> 00:54:13,409
NEXT, A HAPPY SLIDE.

1391
00:54:13,409 --> 00:54:15,477
EACH YEAR WE LOOK BACK AT THE

1392
00:54:15,477 --> 00:54:17,346
PRESS RELEASES AND NEWS RELEASES

1393
00:54:17,346 --> 00:54:20,516
WE'VE DONE OVER THE YEAR.

1394
00:54:20,516 --> 00:54:22,818
AND THESE ARE JUST A SMATTERING

1395
00:54:22,818 --> 00:54:24,353
OF THE GREAT THINGS THAT ARE

1396
00:54:24,353 --> 00:54:27,322
HAPPENING DUE TO NINDS FUNDING.

1397
00:54:27,322 --> 00:54:28,957
BUT I ENCOURAGE PEOPLE TO TAKE A

1398
00:54:28,957 --> 00:54:30,592
LOOK AT THAT.

1399
00:54:30,592 --> 00:54:32,327
IT STRETCHES FROM THE PAPER ON

1400
00:54:32,327 --> 00:54:33,629
HEALTH EQUITY THAT WAS PUT

1401
00:54:33,629 --> 00:54:35,964
TOGETHER BY THE WORKING GROUP

1402
00:54:35,964 --> 00:54:37,166
FOR COUNCIL HERE, AN ENTIRE

1403
00:54:37,166 --> 00:54:39,234
ISSUE OF NEURAL WAS DEDICATED TO

1404
00:54:39,234 --> 00:54:39,768
THAT.

1405
00:54:39,768 --> 00:54:42,971
NEXT TO THAT IS A GWAS STUDY

1406
00:54:42,971 --> 00:54:45,040
WHICH IS AN AMAZING STORY, THIS

1407
00:54:45,040 --> 00:54:48,544
WAS A TRAINING EXERCISE TO TRAIN

1408
00:54:48,544 --> 00:54:54,283
PEOPLE IN AFRICA TO DO GENETIC

1409
00:54:54,283 --> 00:54:56,652
RESEARCH AND TRAINING EXERCISES

1410
00:54:56,652 --> 00:54:57,419
GWAS FOR PARKINSON'S, THEY

1411
00:54:57,419 --> 00:55:00,923
HAPPENED TO HIT A BIG EFFECT

1412
00:55:00,923 --> 00:55:02,991
SIZE LINKAGE TO PARKINSON'S IN

1413
00:55:02,991 --> 00:55:03,325
AFRICA.

1414
00:55:03,325 --> 00:55:09,998
AND IT IS IN AN INTRON ADJACENT

1415
00:55:09,998 --> 00:55:11,834
TO THE GLUCOSE GENE, NOT CLEAR

1416
00:55:11,834 --> 00:55:15,037
WHAT IT DOES, BUT JUST INDICATES

1417
00:55:15,037 --> 00:55:17,206
HOW WE HAVE MISSED A GIANT

1418
00:55:17,206 --> 00:55:20,375
SIGNAL FOR YEARS BECAUSE OUR

1419
00:55:20,375 --> 00:55:22,678
GWASs ALL WERE LOOKING AT

1420
00:55:22,678 --> 00:55:25,214
EUROPEAN POPULATIONS.

1421
00:55:25,214 --> 00:55:27,616
SO A TRAINING EXERCISE, 1800

1422
00:55:27,616 --> 00:55:29,885
PEOPLE, FOUND THIS AMAZING

1423
00:55:29,885 --> 00:55:30,219
FINDING.

1424
00:55:30,219 --> 00:55:32,955
THEN THE NEXT ONE, THE LADY WITH

1425
00:55:32,955 --> 00:55:34,623
THE SPINAL CORD STIMULATOR WE

1426
00:55:34,623 --> 00:55:35,390
TALKED ABOUT.

1427
00:55:35,390 --> 00:55:39,561
AND NEXT TO THAT IS THE STUDY

1428
00:55:39,561 --> 00:55:41,830
THAT WAS DONE WITH INTRACRANIAL

1429
00:55:41,830 --> 00:55:42,731
RECORDINGS AND CLOSED LOOP

1430
00:55:42,731 --> 00:55:43,799
SYSTEM IN SOMEONE WITH SEVERE

1431
00:55:43,799 --> 00:55:47,536
CHRONIC PAIN THAT I MENTIONED.

1432
00:55:47,536 --> 00:55:49,671
THEY DEVELOPED A SIGNATURE IN

1433
00:55:49,671 --> 00:55:52,341
THE ELECTRICAL ACTIVITY OVER THE

1434
00:55:52,341 --> 00:55:54,510
CORTEX THAT CORRELATED WITH

1435
00:55:54,510 --> 00:55:56,178
SEVERE PAIN, AND THAT IN THE

1436
00:55:56,178 --> 00:55:57,479
CLOSED LOOP SYSTEM TRIGGERED THE

1437
00:55:57,479 --> 00:55:59,481
STIMULATOR AND TOOK THE PAIN

1438
00:55:59,481 --> 00:56:00,015
AWAY.

1439
00:56:00,015 --> 00:56:02,084
SO THIS PATIENT WOULD SAY HE

1440
00:56:02,084 --> 00:56:05,687
WOULD FEEL THE PAIN COMING ON,

1441
00:56:05,687 --> 00:56:07,990
AND THEN LIKE BANG, IT WOULD GO

1442
00:56:07,990 --> 00:56:08,223
AWAY.

1443
00:56:08,223 --> 00:56:12,261
THAT BANG, IT WENT AWAY, 

1444
00:56:12,261 --> 00:56:14,329
CONCURRED WITH WHEN THE

1445
00:56:14,329 --> 00:56:15,631
STIMULATOR WENT ON, QUITE AN

1446
00:56:15,631 --> 00:56:16,832
AMAZING STORY.

1447
00:56:16,832 --> 00:56:20,135
BOTTOM IS THE PAPER BY AVI NATH,

1448
00:56:20,135 --> 00:56:22,437
LONG COVID CASES WHICH HE

1449
00:56:22,437 --> 00:56:23,639
NOTICED A NUMBER OF

1450
00:56:23,639 --> 00:56:25,407
ABNORMALITIES IN SPINAL FLUID.

1451
00:56:25,407 --> 00:56:27,809
NEXT ONE AFTER THAT IS A PAPER

1452
00:56:27,809 --> 00:56:32,281
ON CAR-T CELLS USE FOR

1453
00:56:32,281 --> 00:56:36,885
MYASTHENIA GRAVIS, CAUSED BY

1454
00:56:36,885 --> 00:56:38,520
IMMUNE REACTION AGAINST

1455
00:56:38,520 --> 00:56:39,621
ACETYLCHOLINE RECEPTOR, IT'S ONE

1456
00:56:39,621 --> 00:56:45,761
OF THE FIRST REALLY AMAZING 

1457
00:56:45,761 --> 00:56:46,528
FINDINGS IN NEUROTRANSMITTER

1458
00:56:46,528 --> 00:56:48,797
RESEARCH, FROM PROBABLY THE

1459
00:56:48,797 --> 00:56:50,899
'60s, STILL TREATED WITH VERY

1460
00:56:50,899 --> 00:56:51,867
KIND OF BROAD-BASED

1461
00:56:51,867 --> 00:56:52,267
IMMUNOSUPPRESSION.

1462
00:56:52,267 --> 00:56:55,170
THIS IS REALLY A THERAPY THAT

1463
00:56:55,170 --> 00:56:58,674
JUST TARGETS THE CELLS THAT ARE

1464
00:56:58,674 --> 00:57:00,108
MAKING THIS ANTIBODY, ABOUT TIME

1465
00:57:00,108 --> 00:57:04,947
TO GET A PRECISION THERAPY FOR

1466
00:57:04,947 --> 00:57:05,714
MYASTHENIA GRAVIS.

1467
00:57:05,714 --> 00:57:14,089
NEXT IS A  PAPER BY McGAVEEN,

1468
00:57:14,089 --> 00:57:16,225
IN THE MICROGLIA OF THE BRAIN

1469
00:57:16,225 --> 00:57:18,393
HOW TO REPAIR AFTER INJURY.

1470
00:57:18,393 --> 00:57:21,663
THE NEXT ONE IN THAT ROW FROM

1471
00:57:21,663 --> 00:57:26,168
MICHAEL WARD'S LAB AT NIH

1472
00:57:26,168 --> 00:57:28,036
LOOKING AT TDP-43, A PROTEIN

1473
00:57:28,036 --> 00:57:37,346
THAT AGGREGATES IN

1474
00:57:37,346 --> 00:57:39,081
FRONTOTEMPORAL ALS AND

1475
00:57:39,081 --> 00:57:42,050
ALZHEIMER'S, AGGREGATION CAUSES

1476
00:57:42,050 --> 00:57:43,485
AN ABNORMAL EXPRESSION OF

1477
00:57:43,485 --> 00:57:46,888
CRYPTIC EXONS, SO THERE'S A

1478
00:57:46,888 --> 00:57:47,956
SPLICING ABNORMALITY, AND THEY

1479
00:57:47,956 --> 00:57:51,693
WERE ABLE TO SEE THERE WERE

1480
00:57:51,693 --> 00:57:54,196
PROTEINS THAT WERE THEN

1481
00:57:54,196 --> 00:58:03,272
EXPRESSED IN CELLS IN WHICH HAVE

1482
00:58:03,272 --> 00:58:04,506
YOU TDP-43 AGGREGATES, A

1483
00:58:04,506 --> 00:58:05,207
POTENTIAL BIOMARKER.

1484
00:58:05,207 --> 00:58:07,109
IN ADDITION THIS MAY HAVE

1485
00:58:07,109 --> 00:58:09,211
CAUSATIVE EFFECTS, THE PAPER

1486
00:58:09,211 --> 00:58:17,619
RIGHT ABOVE IT, IN DON CLEAVEN'S

1487
00:58:17,619 --> 00:58:21,356
LAB SHOWED EXPRESSION LEADING TO

1488
00:58:21,356 --> 00:58:27,162
LOSS OF FUNCTION OF STAFFMIN,

1489
00:58:27,162 --> 00:58:29,765
LEADING TO AXONAL OUTGROWTH IN

1490
00:58:29,765 --> 00:58:30,966
CULTURED NEURONS, COULD THE

1491
00:58:30,966 --> 00:58:34,269
ABNORMAL SPLICING BE A CAUSE OF

1492
00:58:34,269 --> 00:58:35,470
THE DEGENERATION IN ALS, COULD

1493
00:58:35,470 --> 00:58:37,539
BE MANY OTHER THINGS BUT THAT'S

1494
00:58:37,539 --> 00:58:38,206
ALSO ONE POSSIBILITY.

1495
00:58:38,206 --> 00:58:40,375
AND THEN THE PAPER NEXT TO IT

1496
00:58:40,375 --> 00:58:43,679
WITH THE BRAIN IS FROM THE MAYO

1497
00:58:43,679 --> 00:58:44,313
CLINIC JACKSONVILLE LABS,

1498
00:58:44,313 --> 00:58:45,747
SHOWING IN THE BRAIN OF PEOPLE

1499
00:58:45,747 --> 00:58:50,485
WITH ALZHEIMER'S WHERE YOU SEE

1500
00:58:50,485 --> 00:58:56,391
TPP 43 YOU SEE CRYPTIC EXON IN

1501
00:58:56,391 --> 00:59:00,562
THE PATTERN, THE WHOLE FIELD OF

1502
00:59:00,562 --> 00:59:01,997
TDP-43 IS EXPLODING, NOT THE

1503
00:59:01,997 --> 00:59:07,302
ONLY AREA THAT'S EXPLODING.

1504
00:59:07,302 --> 00:59:10,305
IN SUMMARY I'D LIKE TO EMPHASIZE

1505
00:59:10,305 --> 00:59:13,442
THAT WE FEEL THAT ALTHOUGH WE

1506
00:59:13,442 --> 00:59:15,344
HAVEN'T ACHIEVED WHAT WE WANT TO

1507
00:59:15,344 --> 00:59:16,745
ACHIEVE IN GETTING TREATMENT FOR

1508
00:59:16,745 --> 00:59:18,714
PEOPLE WITH REALLY SEVERE

1509
00:59:18,714 --> 00:59:20,248
NEUROLOGICAL DISEASES, WE FEEL

1510
00:59:20,248 --> 00:59:21,450
THE FIELD IS MAKING A LOT OF

1511
00:59:21,450 --> 00:59:22,084
PROBLEM.

1512
00:59:22,084 --> 00:59:27,589
WE KNOW THESE ARE HARD PROBLEMS.

1513
00:59:27,589 --> 00:59:30,192
AND WE PARTICULARLY AT THIS TIME

1514
00:59:30,192 --> 00:59:32,160
WHEN THE BUDGET BECOMES MORE

1515
00:59:32,160 --> 00:59:32,928
STRAINED IT'S MORE AND MORE

1516
00:59:32,928 --> 00:59:35,664
IMPORTANT TO BE ABLE TO MESSAGE

1517
00:59:35,664 --> 00:59:39,301
OUT AND TO REALLY ADDRESS THESE

1518
00:59:39,301 --> 00:59:43,138
ISSUES WITH URGENCY TO GAIN THE

1519
00:59:43,138 --> 00:59:45,107
TRUST OF THE TAXPAYER.

1520
00:59:45,107 --> 00:59:46,975
WE TRY AND DO THAT HERE AT NIH

1521
00:59:46,975 --> 00:59:48,477
AND I HOPE OTHERS CAN JOIN.

1522
00:59:48,477 --> 00:59:50,379
WITH THAT I'D LIKE TO CLOSE AND

1523
00:59:50,379 --> 00:59:58,553
HAPPY TO ANSWER ANY QUESTIONS. 

1524
00:59:58,553 --> 00:59:59,054
>> THANK YOU.

1525
00:59:59,054 --> 01:00:01,323
IT'S GREAT TO HEAR OF THESE

1526
01:00:01,323 --> 01:00:02,624
EXCITING DISCOVERIES.

1527
01:00:02,624 --> 01:00:04,126
LET'S GO TO SOMETHING UNHAPPY,

1528
01:00:04,126 --> 01:00:05,260
WHICH IS BUDGET.

1529
01:00:05,260 --> 01:00:14,336
YOU MENTIONED THE FACT THAT THE

1530
01:00:14,336 --> 01:00:18,974
$500,000 THRESHOLD CAN'T BE

1531
01:00:18,974 --> 01:00:20,375
REDUCED BECAUSE IT REQUIRES

1532
01:00:20,375 --> 01:00:21,810
BROAD DECISION.

1533
01:00:21,810 --> 01:00:23,445
THE NEW NIH DIRECTOR, NOW WOULD

1534
01:00:23,445 --> 01:00:25,046
BE THE TIME IF YOU'RE EVER GOING

1535
01:00:25,046 --> 01:00:28,583
TO DO THAT TO DECIDE WHETHER TO

1536
01:00:28,583 --> 01:00:30,986
APPROACH THAT AS INSTITUTE-WIDE

1537
01:00:30,986 --> 01:00:31,653
MEASURE.

1538
01:00:31,653 --> 01:00:33,889
I'M NOT SAYING I ADVOCATE BUT IT

1539
01:00:33,889 --> 01:00:39,561
COULD BE A SIMPLE WAY TO DEAL

1540
01:00:39,561 --> 01:00:40,629
WITH BUDGETARY CONSTRAINTS.

1541
01:00:40,629 --> 01:00:41,763
>> THANKS FOR THAT.

1542
01:00:41,763 --> 01:00:45,567
WE ARE HAVING DISCUSSIONS WITH

1543
01:00:45,567 --> 01:00:47,335
THE I.C. DIRECTOR'S TABLE ABOUT

1544
01:00:47,335 --> 01:00:49,604
DIFFERENT WAYS TO TRY TO DEAL

1545
01:00:49,604 --> 01:00:50,005
WITH BUDGETS.

1546
01:00:50,005 --> 01:00:51,706
WE DON'T KNOW WHAT THE CUT IS

1547
01:00:51,706 --> 01:00:54,342
GOING TO BE BUT I THINK THAT'S

1548
01:00:54,342 --> 01:00:58,947
DEFINITELY SOMETHING WE WOULD BE

1549
01:00:58,947 --> 01:01:00,248
PUTTING ON THE TABLE.

1550
01:01:00,248 --> 01:01:03,118
I WOULD SAY AT NIH THE PEOPLE

1551
01:01:03,118 --> 01:01:07,088
REMEMBER YEARS AGO THERE WAS A

1552
01:01:07,088 --> 01:01:09,891
PROPOSAL TO LIMIT THE NUMBER OF

1553
01:01:09,891 --> 01:01:11,626
GRANTS SOMEONE COULD HAVE, THEY

1554
01:01:11,626 --> 01:01:13,728
GAVE A SCORING METHOD, THINGS

1555
01:01:13,728 --> 01:01:15,697
DIDN'T FALL INTO PLACE SO THAT

1556
01:01:15,697 --> 01:01:17,799
WASN'T GOING FORWARD BUT I THINK

1557
01:01:17,799 --> 01:01:21,069
THERE'S -- I WOULD JUST SAY

1558
01:01:21,069 --> 01:01:22,838
THAT'S A TENOR I'VE BEEN HEARING

1559
01:01:22,838 --> 01:01:25,140
IN TERMS OF LIMITING NUMBER OF,

1560
01:01:25,140 --> 01:01:26,007
SAY, R01s.

1561
01:01:26,007 --> 01:01:27,342
BUT EVERYTHING DEPENDS ON WHAT

1562
01:01:27,342 --> 01:01:33,048
THE BUDGET LOOKS LIKE SO STILL 

1563
01:01:33,048 --> 01:01:36,852
IN A WAITING MODE.

1564
01:01:36,852 --> 01:01:37,185
>> SAMEER?

1565
01:01:37,185 --> 01:01:40,021
>> THAT WAS  NICE.

1566
01:01:40,021 --> 01:01:42,190
WHEN WE TALK ABOUT CONTINUING TO

1567
01:01:42,190 --> 01:01:43,992
FY 25 FEELS LIKE WE'RE HUNKERING

1568
01:01:43,992 --> 01:01:46,261
DOWN FOR A STORM THAT MIGHT LAST

1569
01:01:46,261 --> 01:01:48,530
A LOT LONGER THAN WE WERE

1570
01:01:48,530 --> 01:01:50,499
INITIALLY HOPING.

1571
01:01:50,499 --> 01:01:53,034
IF THAT'S THE CASE AND THINGS

1572
01:01:53,034 --> 01:01:55,103
REMAIN FLAT DO YOU IMAGINE

1573
01:01:55,103 --> 01:01:55,971
FURTHER CUTS?

1574
01:01:55,971 --> 01:01:58,540
RIGHT NOW HIGH ADMINISTRATIVE

1575
01:01:58,540 --> 01:02:00,709
CUT, PAYLINE DROP, SCR CUT.

1576
01:02:00,709 --> 01:02:02,344
DO YOU IMAGINE FOR, AS OUT

1577
01:02:02,344 --> 01:02:03,778
YEARS, NEED TO BE FUNDED, MORE

1578
01:02:03,778 --> 01:02:06,281
CUTS IN THE FUTURE?

1579
01:02:06,281 --> 01:02:08,250
AND MY SECOND PART, SUPPOSE

1580
01:02:08,250 --> 01:02:10,619
THINGS GET BETTER, IS THE IDEA

1581
01:02:10,619 --> 01:02:12,521
TO REVERT ALL TO HOW IT WAS A

1582
01:02:12,521 --> 01:02:13,822
COUPLE YEARS AGO?

1583
01:02:13,822 --> 01:02:18,860
I FEEL LIKE AFTER 9/11 THAT FUEL

1584
01:02:18,860 --> 01:02:20,829
CHARGE AT THAT POINT IS STILL

1585
01:02:20,829 --> 01:02:22,130
THERE ON TICKETS.

1586
01:02:22,130 --> 01:02:23,899
I WONDER HOW MANY THINGS CUT CAN

1587
01:02:23,899 --> 01:02:25,433
BE REVERSED BACK TO LEVELS FROM

1588
01:02:25,433 --> 01:02:30,572
A COUPLE YEARS AGO. 

1589
01:02:30,572 --> 01:02:31,439
 

1590
01:02:31,439 --> 01:02:33,308
>> THAT'S THE MILLION
DOLLAR

1591
01:02:33,308 --> 01:02:35,510
QUESTION, SAMEER.

1592
01:02:35,510 --> 01:02:37,812
I WOULD SAY THAT WE ARE READING

1593
01:02:37,812 --> 01:02:39,314
TEA LEAVES, I'M NOT SURE WE'RE

1594
01:02:39,314 --> 01:02:41,416
ANY BETTER THAN WHAT YOU GET

1595
01:02:41,416 --> 01:02:45,554
FROM READING THE PAPER.

1596
01:02:45,554 --> 01:02:47,589
BUT WE'RE HEARING THAT, YOU

1597
01:02:47,589 --> 01:02:52,227
KNOW, THE PRIORITIES AT THE

1598
01:02:52,227 --> 01:02:53,228
GOVERNMENT LEVEL, THERE'S SO

1599
01:02:53,228 --> 01:02:55,096
MUCH PRESSURE IN MULTIPLE

1600
01:02:55,096 --> 01:02:56,464
PRIORITIES THAT WE SHOULDN'T

1601
01:02:56,464 --> 01:03:00,802
EXPECT TO RECEIVE THE SAME KIND

1602
01:03:00,802 --> 01:03:02,003
OF INCREASES WE SAW IN THE LAST

1603
01:03:02,003 --> 01:03:02,871
SIX YEARS.

1604
01:03:02,871 --> 01:03:06,575
THAT'S WHAT WE'RE HEARING.

1605
01:03:06,575 --> 01:03:08,109
NOW, HOW -- WHAT THAT MEANS, THE

1606
01:03:08,109 --> 01:03:12,714
DID HE EVER SILL -- DEVIL IS IN

1607
01:03:12,714 --> 01:03:13,381
THE DETAILS.

1608
01:03:13,381 --> 01:03:16,284
HAVING COME HERE IN 2007 WE DID

1609
01:03:16,284 --> 01:03:18,320
GO FROM 2004 TO 2016 WITH A

1610
01:03:18,320 --> 01:03:19,621
PRETTY MUCH FLAT BUDGET.

1611
01:03:19,621 --> 01:03:22,657
SO WE DO HAVE SOME SENSE OF WHAT

1612
01:03:22,657 --> 01:03:24,626
WE WOULD HAVE TO DO.

1613
01:03:24,626 --> 01:03:27,696
CERTAINLY, YOU KNOW, WE WOULD

1614
01:03:27,696 --> 01:03:29,898
HAVE TO SCALE BACK ON THE THINGS

1615
01:03:29,898 --> 01:03:35,236
WE'RE DOING, THERE MIGHT BE SOME

1616
01:03:35,236 --> 01:03:36,838
INITIATIVES THAT WE CAN'T LAUNCH

1617
01:03:36,838 --> 01:03:39,074
BECAUSE WE DON'T HAVE THE FUNDS.

1618
01:03:39,074 --> 01:03:42,777
WE DO WANT TO MAKE A EQUIPMENT

1619
01:03:42,777 --> 01:03:44,779
TO THE NEW GENERATION THAT WE

1620
01:03:44,779 --> 01:03:48,049
DON'T HIT THEM HARD, THAT WE

1621
01:03:48,049 --> 01:03:51,353
WANT -- BECAUSE THAT WOULD PUT

1622
01:03:51,353 --> 01:03:52,988
US DOWN FOR TEN, TWENTY YEARS.

1623
01:03:52,988 --> 01:03:56,091
SO FOR INSTANCE WITH THE

1624
01:03:56,091 --> 01:03:57,726
EARLY-STAGE INVESTIGATORS, WE

1625
01:03:57,726 --> 01:03:59,160
WANT TO PAY THEM DOUBLE THE

1626
01:03:59,160 --> 01:04:00,695
REGULAR PAYLINE.

1627
01:04:00,695 --> 01:04:06,368
WE'LL PAY UP TO 22  PERCENTILE.

1628
01:04:06,368 --> 01:04:07,802
TRAINING GRANTS WE DON'T WANT TO

1629
01:04:07,802 --> 01:04:09,871
REDUCE AT ALL BECAUSE THAT'S THE

1630
01:04:09,871 --> 01:04:12,874
INVESTMENTS OF THE FUTURE THAT

1631
01:04:12,874 --> 01:04:14,709
SHOULD WE RENEG NOW WE'LL PAY A

1632
01:04:14,709 --> 01:04:15,910
PRICE DOWN THE LINE.

1633
01:04:15,910 --> 01:04:17,312
BUT THEN THERE MIGHT BE A LOT OF

1634
01:04:17,312 --> 01:04:19,814
OTHER THINGS WE JUST CAN'T DO

1635
01:04:19,814 --> 01:04:21,716
BECAUSE WE DON'T HAVE THE FUNDS.

1636
01:04:21,716 --> 01:04:26,554
AS WE HAVE TALKED ABOUT AT

1637
01:04:26,554 --> 01:04:29,057
COUNCIL, THE GENERAL SUGGESTION

1638
01:04:29,057 --> 01:04:29,891
TO US HAS BEEN THAT IN TOUGH

1639
01:04:29,891 --> 01:04:32,394
TIMES IT'S BETTER TO FUND MORE

1640
01:04:32,394 --> 01:04:35,330
GRANTS AT LESS MONEY AS A

1641
01:04:35,330 --> 01:04:35,897
POSSIBILITY GOING FORWARD.

1642
01:04:35,897 --> 01:04:39,668
SO THOSE ARE THE KIND OF JUST

1643
01:04:39,668 --> 01:04:45,106
GENERAL IDEAS FLOWING HERE. 

1644
01:04:45,106 --> 01:04:48,076
WE'RE INTERESTED IN SUGGESTIONS.

1645
01:04:48,076 --> 01:04:51,246
DO YOU HAVE ANY SUGGESTIONS?

1646
01:04:51,246 --> 01:04:52,781
>> WE TALKED ABOUT THE
BOTTOM OF

1647
01:04:52,781 --> 01:04:56,051
THE SLIDE, WHEN YOU CRUNCH THE

1648
01:04:56,051 --> 01:04:58,486
NUMBERS, A GRADUATED GRADIENT,

1649
01:04:58,486 --> 01:05:02,390
RIGHT, OF ADMINISTRATIVE CUT.

1650
01:05:02,390 --> 01:05:04,759
YOU KNOW, IN THE FALL, YOU RAN

1651
01:05:04,759 --> 01:05:06,795
THE NUMBERS, MAYBE IT WAS JUST

1652
01:05:06,795 --> 01:05:07,996
NOT WORTH IT.

1653
01:05:07,996 --> 01:05:09,731
LIKE YOU SAID, BETTER TO HAVE

1654
01:05:09,731 --> 01:05:12,267
SOME FUNDING THAN NOT AT ALL,

1655
01:05:12,267 --> 01:05:13,568
WHETHER YOU'RE NEW INVESTIGATOR

1656
01:05:13,568 --> 01:05:16,638
OR ONE THAT'S BEEN AROUND.

1657
01:05:16,638 --> 01:05:20,909
SEEMED LIKE THAT WAS A GOOD IDEA

1658
01:05:20,909 --> 01:05:23,111
BUT APPARENTLY NOT.

1659
01:05:23,111 --> 01:05:24,979
>> WELL, GOOD IDEA, JUST
IF YOU

1660
01:05:24,979 --> 01:05:27,916
DO THE MATH YOU HAVE -- IF YOU

1661
01:05:27,916 --> 01:05:31,519
WANT TO FUND PEOPLE AT 50% FROM

1662
01:05:31,519 --> 01:05:33,221
11 TO 14 AND ARE ALREADY CUTTING

1663
01:05:33,221 --> 01:05:38,126
AT 20, YOU HAVE TO CUT PEOPLE BY

1664
01:05:38,126 --> 01:05:41,496
50% DOWN TO ABOUT 6th

1665
01:05:41,496 --> 01:05:42,163
PERCENTILE SCORES.

1666
01:05:42,163 --> 01:05:46,000
SO THEN THE MAJORITY OF OUR

1667
01:05:46,000 --> 01:05:47,869
GRANTS WOULD BE ONLY HALF --

1668
01:05:47,869 --> 01:05:49,370
THEY WOULD ONLY GET HALF THE

1669
01:05:49,370 --> 01:05:52,006
MONEY THEY ASKED FOR.

1670
01:05:52,006 --> 01:06:01,649
THAT'S A BIG HIT TOO.

1671
01:06:01,649 --> 01:06:02,050
>> TIM?

1672
01:06:02,050 --> 01:06:03,084
>> WALTER, THAT WAS GREAT.

1673
01:06:03,084 --> 01:06:03,618
THANK YOU.

1674
01:06:03,618 --> 01:06:07,322
RELATED TO THE LAST TOPIC BUT I

1675
01:06:07,322 --> 01:06:09,858
THINK THE -- HOW DEEP DOWN THE

1676
01:06:09,858 --> 01:06:11,159
LIST TO MAKE ADMINISTRATIVE CUTS

1677
01:06:11,159 --> 01:06:14,362
WITH RESPECT TO PRESERVING MORE

1678
01:06:14,362 --> 01:06:17,866
BUDGET, AND ONE COMMENT I'D MAKE

1679
01:06:17,866 --> 01:06:19,400
WITHIN PERCENTILES, I THINK

1680
01:06:19,400 --> 01:06:22,804
THERE'S ASSUMPTION THERE'S AN

1681
01:06:22,804 --> 01:06:24,539
ACCURACY OF RESOLUTION THAT

1682
01:06:24,539 --> 01:06:25,874
SEPARATES DIFFERENT PERCENTILES.

1683
01:06:25,874 --> 01:06:28,176
MY EVEN EXPERIENCE AS A RECEIVER

1684
01:06:28,176 --> 01:06:30,779
AND REVIEWER, ONCE YOU'RE IN THE

1685
01:06:30,779 --> 01:06:33,848
TOP 10% IT'S CAPRICIOUS WHERE

1686
01:06:33,848 --> 01:06:34,716
YOU LAND.

1687
01:06:34,716 --> 01:06:38,887
A LITTLE DEPENDS ON WHO WAS IN

1688
01:06:38,887 --> 01:06:39,320
THE ROOM.

1689
01:06:39,320 --> 01:06:41,723
I TELL PEOPLE WHO ASK FOR

1690
01:06:41,723 --> 01:06:43,925
ADVICE, YOU HAVE TO LAND IN THE

1691
01:06:43,925 --> 01:06:46,761
TOP 10%, THEN IT'S NOISY.

1692
01:06:46,761 --> 01:06:48,496
I THINK IT'S BEEN DANGEROUS TO

1693
01:06:48,496 --> 01:06:50,165
SAY, OH, YOU WANT TO PROTECT THE

1694
01:06:50,165 --> 01:06:51,800
PEOPLE IN THE TOP 6% BECAUSE

1695
01:06:51,800 --> 01:06:54,302
THEY ARE REALLY GOOD.

1696
01:06:54,302 --> 01:06:57,238
THERE'S NO DIFFERENCE.

1697
01:06:57,238 --> 01:06:59,340
THERE MAY BE AT THE VERY END,

1698
01:06:59,340 --> 01:07:00,675
TIPPY TOP BEST GRANT OF THE

1699
01:07:00,675 --> 01:07:06,514
YEAR, THAT MAY BE ONE THING BUT

1700
01:07:06,514 --> 01:07:07,715
ACTUALLY RESOLUTION TO MAKE THAT

1701
01:07:07,715 --> 01:07:09,384
KIND OF CALL, I WOULD SAY YOU

1702
01:07:09,384 --> 01:07:11,653
JUST NEED TO MAKE A BLANKET,

1703
01:07:11,653 --> 01:07:12,287
MAYBE PROTECT EARLY

1704
01:07:12,287 --> 01:07:14,823
INVESTIGATORS SO THEY DON'T

1705
01:07:14,823 --> 01:07:18,726
SUFFER THESE CUTS BUT THAT'S A

1706
01:07:18,726 --> 01:07:19,527
DIFFERENT PHILOSOPHY.

1707
01:07:19,527 --> 01:07:21,162
>> WE DO KNOW A LITTLE
ABOUT THE

1708
01:07:21,162 --> 01:07:24,866
ACCURACY OF THE PERCENTILES.

1709
01:07:24,866 --> 01:07:27,068
JIM NOTH DID THAT STUDY.

1710
01:07:27,068 --> 01:07:29,370
YOU'RE RIGHT.

1711
01:07:29,370 --> 01:07:33,975
PLUS OR MINUS DEPENDS WHERE YOU

1712
01:07:33,975 --> 01:07:34,909
ARE.

1713
01:07:34,909 --> 01:07:37,278
IF JIM IS HERE, FOUR OR FIVE

1714
01:07:37,278 --> 01:07:38,313
PERCENTILES PLUS OR MINE US

1715
01:07:38,313 --> 01:07:41,950
>> IF YOU'RE A FIVE YOU
COULD BE

1716
01:07:41,950 --> 01:07:45,553
AT ONE OR NINE.

1717
01:07:45,553 --> 01:07:50,058
>> RIGHT.

1718
01:07:50,058 --> 01:07:52,827
>> OKAY.

1719
01:07:52,827 --> 01:07:53,127
>> BOB?

1720
01:07:53,127 --> 01:07:57,732
>> BOB, YOU'RE MUTED.

1721
01:07:57,732 --> 01:07:58,700
>> APOLOGIES.

1722
01:07:58,700 --> 01:07:59,200
AGAIN, TERRIFIC REPORT.

1723
01:07:59,200 --> 01:08:01,002
I HAVE A QUESTION WHICH IS A

1724
01:08:01,002 --> 01:08:04,072
LITTLE BIT AT RIGHT ANGLES BUT

1725
01:08:04,072 --> 01:08:05,106
IS IMPORTANT.

1726
01:08:05,106 --> 01:08:06,908
WHAT CONSIDERATIONS IF ANY THERE

1727
01:08:06,908 --> 01:08:10,278
ARE IN NINDS WITH REGARD TO THE

1728
01:08:10,278 --> 01:08:11,713
ISSUE OF INTEGRITY OF SCIENTIFIC

1729
01:08:11,713 --> 01:08:12,080
REPORTING.

1730
01:08:12,080 --> 01:08:13,915
I SAW YOU HAVE ONE INITIATIVE

1731
01:08:13,915 --> 01:08:23,091
RELATED TO  PUBLICATION BIAS.

1732
01:08:23,091 --> 01:08:33,468
THE RECENT OUTREEK  -- OUTBREAK,

1733
01:08:33,468 --> 01:08:36,471
CLAIMS OF PLAGIARISM, IS THERE

1734
01:08:36,471 --> 01:08:38,973
ROLE AS A MAJOR FUNDER TO

1735
01:08:38,973 --> 01:08:44,545
PARTICIPATE IN THAT DISCUSSION 

1736
01:08:44,545 --> 01:08:47,949
AND IN WHAT WAY?

1737
01:08:47,949 --> 01:08:48,816
WALTER, YOU'RE MUTED.

1738
01:08:48,816 --> 01:08:51,119
>> SO I HAVE TO THINK MORE
IN

1739
01:08:51,119 --> 01:08:54,722
TERMS OF GETTING AT YOUR WHOLE

1740
01:08:54,722 --> 01:08:55,223
QUESTION.

1741
01:08:55,223 --> 01:08:58,359
SO WE HAVE -- NIH HAS A SYSTEM

1742
01:08:58,359 --> 01:08:59,994
OF RESEARCH INTEGRITY WHERE

1743
01:08:59,994 --> 01:09:03,698
ALLEGATIONS COME IN.

1744
01:09:03,698 --> 01:09:04,699
THERE'S A VERY CONFIDENTIAL

1745
01:09:04,699 --> 01:09:07,535
PROCESS BY WHICH THEY ARE ALL

1746
01:09:07,535 --> 01:09:09,938
INVESTIGATED AND ACTED UPON.

1747
01:09:09,938 --> 01:09:13,007
SO THAT IS ONGOING AND VERY

1748
01:09:13,007 --> 01:09:13,942
ACTIVE, UNFORTUNATELY.

1749
01:09:13,942 --> 01:09:15,276
AND THEN THERE'S THE OTHER

1750
01:09:15,276 --> 01:09:21,549
PROCESS WHICH WE HAVE REALLY

1751
01:09:21,549 --> 01:09:25,653
PIONEERED THANKS TO SILVERBERG,

1752
01:09:25,653 --> 01:09:27,355
THE IMPORTANCE OF DOING SCIENCE

1753
01:09:27,355 --> 01:09:28,222
RIGHT.

1754
01:09:28,222 --> 01:09:30,058
IT'S NOT THE SAME.

1755
01:09:30,058 --> 01:09:32,493
CHEATING IS NOT THE SAME AS

1756
01:09:32,493 --> 01:09:32,794
SLOPPINESS.

1757
01:09:32,794 --> 01:09:35,964
BUT THEY ARE BOTH BAD.

1758
01:09:35,964 --> 01:09:38,399
AND PARTICULARLY CHEATING.

1759
01:09:38,399 --> 01:09:38,900
TERRIBLE.

1760
01:09:38,900 --> 01:09:41,569
BUT WE HAVE MADE THIS BIG

1761
01:09:41,569 --> 01:09:42,103
INVESTMENT.

1762
01:09:42,103 --> 01:09:46,808
WE HAVE NOW CENTERS THAT ARE

1763
01:09:46,808 --> 01:09:47,275
DEVELOPING EDUCATIONAL

1764
01:09:47,275 --> 01:09:48,776
MATERIALS, WORKSHOPS, WE HAVE A

1765
01:09:48,776 --> 01:09:49,877
RIGOR WORKING GROUP THAT MEETS

1766
01:09:49,877 --> 01:09:53,681
ALL THE TIME TRYING TO GET --

1767
01:09:53,681 --> 01:09:55,350
IMPROVE QUALITY OF THE SCIENCE

1768
01:09:55,350 --> 01:09:56,451
THAT WE FUND.

1769
01:09:56,451 --> 01:09:58,319
AND THAT'S WHERE WE THINK THAT

1770
01:09:58,319 --> 01:10:02,890
WE CAN MAKE THE BEST EFFORT

1771
01:10:02,890 --> 01:10:04,258
PROBABLY MORE AS TEACHERS

1772
01:10:04,258 --> 01:10:05,393
ENGAGING WITH TEACHERS IN TERMS

1773
01:10:05,393 --> 01:10:10,231
OF THAT AND NOT AS POLICEMEN.

1774
01:10:10,231 --> 01:10:12,200
BUT OPEN, IF PEOPLE HAVE

1775
01:10:12,200 --> 01:10:17,772
SUGGESTIONS, OPEN TO SUGGESTIONS

1776
01:10:17,772 --> 01:10:17,972
THERE.

1777
01:10:17,972 --> 01:10:18,473
>> I WON'T BELABOR.

1778
01:10:18,473 --> 01:10:21,576
AT LEAST IN THE RECENT HARVARD

1779
01:10:21,576 --> 01:10:22,710
CASES THERE WERE INVOLVED

1780
01:10:22,710 --> 01:10:26,647
PROMINENT P.I.s WHO HAD NOT

1781
01:10:26,647 --> 01:10:27,415
REALLY SERIOUSLY BEEN

1782
01:10:27,415 --> 01:10:30,251
ADJUDICATED BEFORE WITH RESPECT

1783
01:10:30,251 --> 01:10:30,585
TO PLAGIARISM.

1784
01:10:30,585 --> 01:10:31,786
BUT NO ONE LOOKED.

1785
01:10:31,786 --> 01:10:33,321
SO THE QUESTION, IS THERE SOME

1786
01:10:33,321 --> 01:10:36,057
PRO-ACTIVE WAY TO THINK ABOUT

1787
01:10:36,057 --> 01:10:40,762
THIS PARTICULARLY PERHAPS AMONG

1788
01:10:40,762 --> 01:10:41,963
FOLKS WHO AT LEAST WON'T SUSPECT

1789
01:10:41,963 --> 01:10:46,868
OF BEING INVOLVED WITH THAT, 

1790
01:10:46,868 --> 01:10:47,902
JUST A SIDE CONSIDERATION.

1791
01:10:47,902 --> 01:10:51,906
>> I'M GOING TO THINK
ABOUT

1792
01:10:51,906 --> 01:10:52,573
THAT, BOB.

1793
01:10:52,573 --> 01:10:54,308
THAT MIGHT BE SOMETHING TO

1794
01:10:54,308 --> 01:10:56,411
DISCUSSION WITH THE OFFICE OF

1795
01:10:56,411 --> 01:11:00,014
EXTRAMURAL RESEARCH ONE BY MIKE

1796
01:11:00,014 --> 01:11:02,950
LAUER WHERE MOST OF THOSE

1797
01:11:02,950 --> 01:11:06,020
PROCESSES WOULD OCCUR, SO A

1798
01:11:06,020 --> 01:11:07,455
PRO-ACTIVE LOOK.

1799
01:11:07,455 --> 01:11:08,790
OKAY, THANKS.

1800
01:11:08,790 --> 01:11:08,956
AMY?

1801
01:11:08,956 --> 01:11:09,557
>> YEAH, THANKS.

1802
01:11:09,557 --> 01:11:12,393
I WANTED TO GET BACK TO THE

1803
01:11:12,393 --> 01:11:13,394
BUDGET QUESTION.

1804
01:11:13,394 --> 01:11:16,831
SO I'M CURIOUS HOW YOU'RE

1805
01:11:16,831 --> 01:11:17,698
THINKING ABOUT ADMINISTRATIVE

1806
01:11:17,698 --> 01:11:18,633
CUTS VERSUS BUDGET CAPS.

1807
01:11:18,633 --> 01:11:20,501
I GUESS WHAT I'M THINKING IS I

1808
01:11:20,501 --> 01:11:23,571
FEEL LIKE WHEN YOU HAVE SORT OF

1809
01:11:23,571 --> 01:11:26,507
ADMINISTRATIVE CUTS ACROSS THE

1810
01:11:26,507 --> 01:11:28,810
BOARD IT INCENTIVIZES PEOPLE TO

1811
01:11:28,810 --> 01:11:30,344
PAD THEIR BUDGET IN ANTICIPATION

1812
01:11:30,344 --> 01:11:33,848
OF CUTS OR TO NOT PAD BUDGET, IN

1813
01:11:33,848 --> 01:11:35,817
WHICH CASE THE SCOPE OF WORK NO

1814
01:11:35,817 --> 01:11:37,151
LONGER ALIGNS WITH THE BUDGET

1815
01:11:37,151 --> 01:11:38,786
THEY ARE RECEIVING AND I THINK

1816
01:11:38,786 --> 01:11:42,723
THAT CAN NEGATIVELY IMPACT THE

1817
01:11:42,723 --> 01:11:43,091
SCIENCE.

1818
01:11:43,091 --> 01:11:44,692
SO, I'M CURIOUS IF YOU THOUGHT

1819
01:11:44,692 --> 01:11:46,461
ABOUT THE POSSIBILITY OF DOING

1820
01:11:46,461 --> 01:11:47,895
MORE BUDGET CAPS WHERE PEOPLE

1821
01:11:47,895 --> 01:11:49,831
CAN KNOW THIS IS WHAT WE CAN

1822
01:11:49,831 --> 01:11:52,366
BUDGET FOR AND LOWERING THE

1823
01:11:52,366 --> 01:11:53,468
BUDGET CAPS AND APPROPRIATELY

1824
01:11:53,468 --> 01:11:56,404
ADJUSTING THEIR SCOPE OF WORK

1825
01:11:56,404 --> 01:11:58,139
AND SCIENTIFIC AIMS, IN

1826
01:11:58,139 --> 01:12:01,976
ANTICIPATION OF THAT AS AN

1827
01:12:01,976 --> 01:12:02,743
ALTERNATIVE.

1828
01:12:02,743 --> 01:12:04,846
>> YEAH, I THINK THAT'S
REALLY

1829
01:12:04,846 --> 01:12:05,113
IMPORTANT.

1830
01:12:05,113 --> 01:12:08,249
AND WE DO THAT TO SOME EXTENT IN

1831
01:12:08,249 --> 01:12:10,918
THE SENSE THAT TO ASK FOR MORE

1832
01:12:10,918 --> 01:12:11,853
THAN $500,000 YOU HAVE TO SUBMIT

1833
01:12:11,853 --> 01:12:16,224
TO US AND WE HAVE TO APPROVE IT

1834
01:12:16,224 --> 01:12:16,657
GOING FORWARD.

1835
01:12:16,657 --> 01:12:20,928
AT THE LAST COUNCIL WE SHOWED 

1836
01:12:20,928 --> 01:12:22,563
THAT GRANTS ARE COMING IN

1837
01:12:22,563 --> 01:12:24,832
GIGANTIC SPIKE IN FRONT OF

1838
01:12:24,832 --> 01:12:25,099
$500,000.

1839
01:12:25,099 --> 01:12:26,968
IN FACT WE ARE EXPERTING

1840
01:12:26,968 --> 01:12:29,370
SOMEWHAT OF A BUDGET CAP ON THAT

1841
01:12:29,370 --> 01:12:31,005
SPACE, AND WE MIGHT HAVE TO BE

1842
01:12:31,005 --> 01:12:34,175
MORE STRINGENT IN DOING THAT.

1843
01:12:34,175 --> 01:12:38,212
AND THEN THE TRICK THEN IS BEING

1844
01:12:38,212 --> 01:12:40,815
FLEXIBLE ENOUGH SO THAT YOU

1845
01:12:40,815 --> 01:12:42,383
DON'T PREVENT CERTAIN RESEARCH

1846
01:12:42,383 --> 01:12:44,252
FROM HAPPENING BECAUSE IT'S

1847
01:12:44,252 --> 01:12:45,186
INHERENTLY MORE EXPENSIVE.

1848
01:12:45,186 --> 01:12:47,955
SO LIKE A CLINICAL TRIAL FOR

1849
01:12:47,955 --> 01:12:50,258
INSTANCE YOU CAN'T PROPOSE A

1850
01:12:50,258 --> 01:12:52,460
BUDGET CAP FOR AN R01 AND

1851
01:12:52,460 --> 01:12:54,328
CLINICAL TRIAL AND BE WORKING

1852
01:12:54,328 --> 01:12:54,962
WITH, SAY, NON-HUMAN PRIMATES,

1853
01:12:54,962 --> 01:12:57,031
THAT'S GOING TO BE MORE

1854
01:12:57,031 --> 01:12:59,433
EXPENSIVE, SOME SEQUENCING STUFF

1855
01:12:59,433 --> 01:13:00,635
IS MORE EXPENSIVE.

1856
01:13:00,635 --> 01:13:07,542
THAT'S WHY WE DO IT MORE CASE BY

1857
01:13:07,542 --> 01:13:08,743
CASE.

1858
01:13:08,743 --> 01:13:10,745
>> IF WE DID CUT BEYOND A

1859
01:13:10,745 --> 01:13:12,580
CERTAIN POINT, 25%, WE HAVE TO

1860
01:13:12,580 --> 01:13:13,881
RENEGOTIATE AIMS SO IT DOES

1861
01:13:13,881 --> 01:13:19,921
ADJUST THAT. 

1862
01:13:19,921 --> 01:13:21,923
>> MY LAST QUESTION WAS
RELATED

1863
01:13:21,923 --> 01:13:23,658
TO THIS, DAVID.

1864
01:13:23,658 --> 01:13:26,060
THAT THRESHOLD OF BEING ABLE TO

1865
01:13:26,060 --> 01:13:27,795
ALTER THE AIMS WHEN THE BUDGET

1866
01:13:27,795 --> 01:13:30,097
HAS BEEN REDUCED BY SAY 20%

1867
01:13:30,097 --> 01:13:31,766
DOESN'T FALL UNDER NIH GUIDELINE

1868
01:13:31,766 --> 01:13:34,702
YOU COULD  RENEGOTIATE THE AIM

1869
01:13:34,702 --> 01:13:37,104
BUT IT'S A BIG CUT OF WHAT YOU

1870
01:13:37,104 --> 01:13:39,740
CAN DO SO THERE MAY BE A LONG

1871
01:13:39,740 --> 01:13:41,609
SIDE MAKING MORE DRACONIAN CUTS,

1872
01:13:41,609 --> 01:13:47,181
EASTERN FIT  -- EVEN IF IT

1873
01:13:47,181 --> 01:13:48,816
DOESN'T REACH THE THRESHOLD,

1874
01:13:48,816 --> 01:13:51,018
THAT'S AN NIH-WIDE ROLE,

1875
01:13:51,018 --> 01:13:52,119
THRESHOLD FOR NEGOTIATION, BUT I

1876
01:13:52,119 --> 01:13:54,722
DON'T THINK IT ALIGNS WELL, 20%

1877
01:13:54,722 --> 01:13:56,824
CUT TO A GRANT YOU SHOULD BE

1878
01:13:56,824 --> 01:13:58,559
ABLE TO SAY, LISTEN, I WANT TO

1879
01:13:58,559 --> 01:14:01,629
SAVE THIS CHUNK OF AIM FOR --

1880
01:14:01,629 --> 01:14:03,397
I'LL APPLY TO SOME FOUNDATION TO

1881
01:14:03,397 --> 01:14:06,000
DO THAT.

1882
01:14:06,000 --> 01:14:10,137
>> JUST TO FOLLOW THAT
LINE OF

1883
01:14:10,137 --> 01:14:12,907
THOUGHT, TIM, YOU'RE SAYING THAT

1884
01:14:12,907 --> 01:14:17,712
IF YOU GET SAY A 20% CUT, THAT

1885
01:14:17,712 --> 01:14:20,014
YOU ARE THEN ABLE TO RESTRUCTURE

1886
01:14:20,014 --> 01:14:22,183
YOUR AIMS, IS THAT WHAT YOU'RE

1887
01:14:22,183 --> 01:14:23,618
SAYING?

1888
01:14:23,618 --> 01:14:24,819
>> THAT'S WHAT I'M
ADVOCATING.

1889
01:14:24,819 --> 01:14:27,121
FEELS LIKE 25% IS A PRETTY FAR

1890
01:14:27,121 --> 01:14:32,093
OFF LINE TO HAVE TO CROSS FOR

1891
01:14:32,093 --> 01:14:32,760
RENEGOTIATION.

1892
01:14:32,760 --> 01:14:33,394
>> YEAH.

1893
01:14:33,394 --> 01:14:33,694
OKAY.

1894
01:14:33,694 --> 01:14:35,663
>> IT WOULD IDEALLY BE
MORE,

1895
01:14:35,663 --> 01:14:42,136
YEAH, A CENTRALIZED APPROACH AS

1896
01:14:42,136 --> 01:14:44,105
OPPOSED TO (INDISCERNIBLE).

1897
01:14:44,105 --> 01:14:44,438
>> OKAY.

1898
01:14:44,438 --> 01:14:48,276
SO I GUESS WE'RE HOPING THAT

1899
01:14:48,276 --> 01:14:52,780
MEMBER THIS IS JUST PREPARATION,

1900
01:14:52,780 --> 01:14:53,547
NEEDLESS PREPARATION, BUT

1901
01:14:53,547 --> 01:14:57,918
HOPEFULLY WE'LL LEARN MORE IN 

1902
01:14:57,918 --> 01:14:58,085
MAY.

1903
01:14:58,085 --> 01:15:00,221
I GUESS WE'LL PROBABLY HAVE A

1904
01:15:00,221 --> 01:15:03,457
CONTINUING RESOLUTION GOING

1905
01:15:03,457 --> 01:15:03,691
FORWARD.

1906
01:15:03,691 --> 01:15:04,992
NEXT TIME WE MEET.

1907
01:15:04,992 --> 01:15:06,560
IN MARCH, YEAH, THEY COULD JUST

1908
01:15:06,560 --> 01:15:12,333
KICK THE CAN AGAIN. 

1909
01:15:12,333 --> 01:15:18,039
>> GREAT TO HEAR ALL THE 

1910
01:15:18,039 --> 01:15:18,739
PROGRESS, PARTICULARLY ALSO

1911
01:15:18,739 --> 01:15:20,675
ABOUT THE POST STRATEGIES

1912
01:15:20,675 --> 01:15:24,945
RECOMMENDATIONS, THAT COMES WITH

1913
01:15:24,945 --> 01:15:26,681
REALLY INCREASE OF POSTDOC

1914
01:15:26,681 --> 01:15:29,884
BENEFITS AND THE GRANT THAT'S

1915
01:15:29,884 --> 01:15:31,519
PROBABLY BEEN SET.

1916
01:15:31,519 --> 01:15:37,091
SO THE QUESTION RELATED TO THIS 

1917
01:15:37,091 --> 01:15:38,726
RECOMMENDATION IS IT ONLY FOR

1918
01:15:38,726 --> 01:15:41,462
(INDISCERNIBLE) AWARDS OR WHAT

1919
01:15:41,462 --> 01:15:43,898
ABOUT THE POSTDOCS BEING FUNDED

1920
01:15:43,898 --> 01:15:47,368
ON FUNDED RPG GRANTS?

1921
01:15:47,368 --> 01:15:50,771
HOW DO YOU BALANCE THE

1922
01:15:50,771 --> 01:15:52,940
DIFFERENCES OVER PRESUMABLY

1923
01:15:52,940 --> 01:15:53,574
COMING UP TO 2024 AND MANY OF

1924
01:15:53,574 --> 01:15:58,846
THE P.I.s ARE NOT ABLE TO

1925
01:15:58,846 --> 01:15:59,613
OBTAIN GRANTS.

1926
01:15:59,613 --> 01:16:03,017
>> SO THAT'S THE ROCK AND
THE

1927
01:16:03,017 --> 01:16:04,652
HARD PLACE PROBLEM THAT THE

1928
01:16:04,652 --> 01:16:08,055
COSTS ARE GOING UP AND AMOUNT OF

1929
01:16:08,055 --> 01:16:10,558
MONEY IS NOT.

1930
01:16:10,558 --> 01:16:13,094
BUT I WOULD SAY ABOUT WHAT YOU

1931
01:16:13,094 --> 01:16:14,395
MENTIONED ABOUT THE POSTDOCS,

1932
01:16:14,395 --> 01:16:17,465
THE PEOPLE MAY OR MAY NOT KNOW

1933
01:16:17,465 --> 01:16:20,501
THAT MAJORITY OF POSTDOCS FUNDED

1934
01:16:20,501 --> 01:16:23,371
BY NIH MONEY ARE OFF OF GRANTS

1935
01:16:23,371 --> 01:16:26,874
AND NOT FUNDED BY FELLOWSHIP

1936
01:16:26,874 --> 01:16:27,408
AWARDS.

1937
01:16:27,408 --> 01:16:32,646
AND THE RECOMMENDATIONS FROM THE

1938
01:16:32,646 --> 01:16:36,917
COMMITTEE IS THAT NIH MANDATE

1939
01:16:36,917 --> 01:16:38,886
THAT THOSE POSTDOCS RECEIVE THE

1940
01:16:38,886 --> 01:16:41,188
SAME BENEFITS AND SALARY AS WHAT

1941
01:16:41,188 --> 01:16:45,893
GETS ON THE FELLOWSHIP GRANTS.

1942
01:16:45,893 --> 01:16:47,962
THAT'S THE RECOMMENDATION.

1943
01:16:47,962 --> 01:16:51,799
BUT AS YOU SAID, NIH HASN'T

1944
01:16:51,799 --> 01:16:53,000
REALLY OPERATIONALIZED THOSE

1945
01:16:53,000 --> 01:16:54,535
RECOMMENDATIONS YET, MAINLY FOR

1946
01:16:54,535 --> 01:16:57,071
THE REASONS, AS YOU MENTIONED,

1947
01:16:57,071 --> 01:17:00,341
HOW TO DO THAT, PARTICULARLY IF 

1948
01:17:00,341 --> 01:17:01,308
DO YOU THAT SUDDENLY, THERE'S

1949
01:17:01,308 --> 01:17:02,610
THERE MAY BE VERY LITTLE MONEY

1950
01:17:02,610 --> 01:17:04,812
LEFT TO DO THE SCIENCE.

1951
01:17:04,812 --> 01:17:06,580
SO WE'RE KIND OF STUCK THERE.

1952
01:17:06,580 --> 01:17:07,882
SO I THINK PEOPLE STILL ARE

1953
01:17:07,882 --> 01:17:11,051
TRYING TO WORK OUT HOW THAT

1954
01:17:11,051 --> 01:17:12,586
COULD HAPPEN.

1955
01:17:12,586 --> 01:17:15,423
BUT IT DOES, YOU KNOW, THE

1956
01:17:15,423 --> 01:17:17,925
RECOMMENDATION IS THAT WE HAVE

1957
01:17:17,925 --> 01:17:20,795
SO FAR BEEN IGNORING THE PLIGHT

1958
01:17:20,795 --> 01:17:22,630
OF POSTDOCS ON R01 GRANTS AND

1959
01:17:22,630 --> 01:17:24,265
THAT SHOULD STOP.

1960
01:17:24,265 --> 01:17:25,466
AND WE REALLY SHOULD LOOK AT

1961
01:17:25,466 --> 01:17:27,468
THOSE FOLKS JUST LIKE WE LOOK AT

1962
01:17:27,468 --> 01:17:38,012
PEOPLE ON THE FELLOWSHIP GRANTS.

1963
01:17:40,881 --> 01:17:42,450
NOT WITHOUT AN INCREASE IN

1964
01:17:42,450 --> 01:17:43,651
BUDGET, RIGHT.

1965
01:17:43,651 --> 01:17:45,186
IT WOULD BE GREAT, INCREASE OF

1966
01:17:45,186 --> 01:17:47,621
BUDGET.

1967
01:17:47,621 --> 01:17:51,091
 

1968
01:17:51,091 --> 01:17:51,358
>> OKAY.

1969
01:17:51,358 --> 01:17:53,394
>> THANKS, EVERYONE.

1970
01:17:53,394 --> 01:17:54,161
IF ANYBODY HAS SUGGESTIONS,

1971
01:17:54,161 --> 01:17:55,463
ESPECIALLY ON THE FINANCIAL

1972
01:17:55,463 --> 01:17:58,532
SIDE, PLEASE LET ME KNOW.

1973
01:17:58,532 --> 01:17:58,699
 

1974
01:17:58,699 --> 01:18:00,067
>> YEAH, IT'S TRICKY.

1975
01:18:00,067 --> 01:18:02,603
SOME OF THESE ARE ZERO SUM

1976
01:18:02,603 --> 01:18:02,837
GAINS.

1977
01:18:02,837 --> 01:18:04,805
SO WE'RE A LITTLE AHEAD OF

1978
01:18:04,805 --> 01:18:07,875
SCHEDULE.

1979
01:18:07,875 --> 01:18:12,680
YAY, I DID IT!

1980
01:18:12,680 --> 01:18:14,548
YES, VERY GOOD.

1981
01:18:14,548 --> 01:18:19,987
OPTIMIZATION OF THE ECB.

1982
01:18:19,987 --> 01:18:22,490
WHY DON'T WE TAKE A BREAK AND

1983
01:18:22,490 --> 01:18:24,959
RECONVENE AT 2:45 AND WE'RE
STILL AHEAD OF SCHEDULE. 

1984
01:18:24,959 --> 01:18:26,969
>> IS THAT GOOD, 2:45,
FOLKS?
>> OKAY.

1985
01:18:43,892 --> 01:18:45,427
>> OKAY, WELCOME BACK.

1986
01:18:45,427 --> 01:18:47,929
IT'S MY GREAT PLEASURE TO

1987
01:18:47,929 --> 01:18:49,531
INTRODUCE DR. HELENE LANGEVIN,

1988
01:18:49,531 --> 01:18:51,766
DIRECTOR OF THE NATIONAL CENTER

1989
01:18:51,766 --> 01:18:53,835
FOR COMPLEMENTARY AND

1990
01:18:53,835 --> 01:18:54,836
INTEGRATIVE HEALTH.

1991
01:18:54,836 --> 01:18:57,339
SHE'S BEEN JUST A GREAT

1992
01:18:57,339 --> 01:19:04,679
COLLEAGUE AND SHE SERVES AS THE

1993
01:19:04,679 --> 01:19:06,648
CO-DIRECTOR OF THE INSTITUTE

1994
01:19:06,648 --> 01:19:08,149
DIRECTOR COMMITTEE FOR PAIN HEAL

1995
01:19:08,149 --> 01:19:09,484
INITIATIVE INITIATIVE, DIRECTOR

1996
01:19:09,484 --> 01:19:12,654
OF THE INTERAGENCY PAIN RESEARCH

1997
01:19:12,654 --> 01:19:13,755
COORDINATING COMMITTEE, CHAIRS

1998
01:19:13,755 --> 01:19:17,792
THAT, AND HAS A LOT OF 

1999
01:19:17,792 --> 01:19:20,095
EXPERIENCE ON THE PAIN SIDE.

2000
01:19:20,095 --> 01:19:22,931
SHE CAME TO NCCIH FROM BRIGHAM

2001
01:19:22,931 --> 01:19:24,466
AND WOMEN'S HOSPITAL, WAS

2002
01:19:24,466 --> 01:19:27,636
PROFESSOR OF MEDICINE, CENTER

2003
01:19:27,636 --> 01:19:28,970
FOR INTEGRATIVE MEDICINE.

2004
01:19:28,970 --> 01:19:32,240
SHE WILL DISCUSS THE MULTI-I.C.

2005
01:19:32,240 --> 01:19:34,209
PROGRAM MUSCULOSKELETAL PAIN AND

2006
01:19:34,209 --> 01:19:37,512
HER THOUGHTS ABOUT HOW WE CAN

2007
01:19:37,512 --> 01:19:41,883
WORK WITH HER TO ACCELERATE THE

2008
01:19:41,883 --> 01:19:42,551
WHOLE-PERSON HEALTH.

2009
01:19:42,551 --> 01:19:45,687
SHE RECEIVED HER M.D. FROM

2010
01:19:45,687 --> 01:19:46,922
McGILL, MONTREAL, AND DID

2011
01:19:46,922 --> 01:19:50,625
POSTDOC WORK AT THE MRC AT

2012
01:19:50,625 --> 01:19:52,160
CAMBRIDGE, WAS A RESIDENT IN

2013
01:19:52,160 --> 01:19:57,966
INTERNAL MEDICINE AND FELLOWSHIP

2014
01:19:57,966 --> 01:19:59,601
IN ENDOCRINE AT HOPKINS PRIOR TO

2015
01:19:59,601 --> 01:20:02,037
MOVING TO ACADEMIA.

2016
01:20:02,037 --> 01:20:04,639
HELENE, THANKS FOR COMING.

2017
01:20:04,639 --> 01:20:07,475
>> WELL, THANK YOU SO
MUCH,

2018
01:20:07,475 --> 01:20:08,677
WALTER FOR THE WONDERFUL

2019
01:20:08,677 --> 01:20:10,779
INVITATION TO COME AND PRESENT

2020
01:20:10,779 --> 01:20:15,383
SOME OF THE IDEAS THAT WE'VE 

2021
01:20:15,383 --> 01:20:17,218
BEEN SORT OF DISCUSSING, WITHIN

2022
01:20:17,218 --> 01:20:19,621
THE HEAL INITIATIVE, IT'S BEEN A

2023
01:20:19,621 --> 01:20:22,691
FANTASTIC FORUM TO TALK ABOUT

2024
01:20:22,691 --> 01:20:23,959
INTERDISCIPLINARY RESEARCH.

2025
01:20:23,959 --> 01:20:27,495
AS WALTER SAYS, "HEAL" CAN DO A

2026
01:20:27,495 --> 01:20:29,130
LOT OF WHAT INDIVIDUAL

2027
01:20:29,130 --> 01:20:30,365
INSTITUTES CANNOT DO ON OUR OWN,

2028
01:20:30,365 --> 01:20:33,635
ESPECIALLY IN THE PAIN FIELD.

2029
01:20:33,635 --> 01:20:37,038
THIS IS REALLY A VERY -- A

2030
01:20:37,038 --> 01:20:40,342
GODSEND FOR US AT NCCIH TO

2031
01:20:40,342 --> 01:20:41,876
COLLABORATE WITH OUR COLLEAGUES

2032
01:20:41,876 --> 01:20:44,579
ACROSS AND ESPECIALLY AT NINDS,

2033
01:20:44,579 --> 01:20:49,751
BUT ALSO NIAMS, CHILD HEALTH,

2034
01:20:49,751 --> 01:20:50,819
NIBIB, NIAAA, AND NIDA.

2035
01:20:50,819 --> 01:20:54,556
I'M GOING TO TALK ABOUT SOME NEW

2036
01:20:54,556 --> 01:20:57,158
DIRECTIONS IN PAIN RESEARCH.

2037
01:20:57,158 --> 01:21:00,362
AND ALSO SHOW YOU SOME OF THE

2038
01:21:00,362 --> 01:21:01,062
PROGRAMS THAT WITHIN "HEAL" THAT

2039
01:21:01,062 --> 01:21:11,606
HAVE BEEN SORT OF MOVING US IN 

2040
01:21:15,744 --> 01:21:18,079
THOSE DIRECTIONS.

2041
01:21:18,079 --> 01:21:23,018
 

2042
01:21:23,018 --> 01:21:25,253
CLICK, THERE WE GO.

2043
01:21:25,253 --> 01:21:29,124
SO, I'M GOING TO TALK ABOUT TWO

2044
01:21:29,124 --> 01:21:32,227
SORT OF WE COULD CALL THEM GAPS

2045
01:21:32,227 --> 01:21:36,131
OR CHALLENGES, SOMETHING THAT

2046
01:21:36,131 --> 01:21:37,766
NCCIH WOULD LIKE TO SEE MORE OF.

2047
01:21:37,766 --> 01:21:41,169
ONE IS CONNECTING THE NERVOUS

2048
01:21:41,169 --> 01:21:43,905
SYSTEM WITH OTHER PARTS OF THE

2049
01:21:43,905 --> 01:21:44,339
BODY.

2050
01:21:44,339 --> 01:21:49,244
SPECIFICALLY I'M GOING TO TALK

2051
01:21:49,244 --> 01:21:50,912
ABOUT MUSCULOSKELETAL TISSUES

2052
01:21:50,912 --> 01:21:51,980
AND MUSCULOSKELETAL SYSTEM BUT

2053
01:21:51,980 --> 01:21:58,353
IT COULD APPLY TO OTHER SYSTEMS,

2054
01:21:58,353 --> 01:21:59,020
GASTROINTESTINAL, GENITOURINARY,

2055
01:21:59,020 --> 01:22:00,655
ET CETERA, CONNECTING THE

2056
01:22:00,655 --> 01:22:01,756
NERVOUS SYSTEM WITH WHAT'S GOING

2057
01:22:01,756 --> 01:22:01,956
ON.

2058
01:22:01,956 --> 01:22:03,625
WE THINK THIS IS REALLY

2059
01:22:03,625 --> 01:22:04,693
IMPORTANT FOR PAIN.

2060
01:22:04,693 --> 01:22:10,498
AND THE SECOND PIECE IS 

2061
01:22:10,498 --> 01:22:11,499
UNDERSTANDING AND SUPPORTING

2062
01:22:11,499 --> 01:22:12,467
ENDOGENOUS PAIN RESOLUTION.

2063
01:22:12,467 --> 01:22:15,203
HOW DOES PAIN GO AWAY?

2064
01:22:15,203 --> 01:22:17,305
IF WE DIDN'T HAVE MECHANISMS

2065
01:22:17,305 --> 01:22:18,606
INSIDE US TO MAKE PAIN GO AWAY

2066
01:22:18,606 --> 01:22:22,644
WE WOULD BE IN PAIN ALL DAY LONG

2067
01:22:22,644 --> 01:22:26,247
FOR EVERY SINGLE PAPER CUT.

2068
01:22:26,247 --> 01:22:28,349
AND UNDERSTANDING HOW DOES ACUTE

2069
01:22:28,349 --> 01:22:31,920
PAIN NOT PROGRESS TO CHRONIC

2070
01:22:31,920 --> 01:22:32,587
PAIN.

2071
01:22:32,587 --> 01:22:34,989
SO, THE FIRST OF THESE GAPS,

2072
01:22:34,989 --> 01:22:36,424
CONNECTING NERVOUS SYSTEM AND

2073
01:22:36,424 --> 01:22:39,694
MUSCULOSKELETAL TISSUES AND 

2074
01:22:39,694 --> 01:22:40,061
ENVIRONMENT.

2075
01:22:40,061 --> 01:22:41,329
WHAT DO I MEAN?

2076
01:22:41,329 --> 01:22:44,065
A LOT OF RESEARCH WE DO ON PAIN,

2077
01:22:44,065 --> 01:22:44,666
UNDERSTANDING PAIN MECHANISM,

2078
01:22:44,666 --> 01:22:47,936
HAS TO DO WITH THE NERVOUS

2079
01:22:47,936 --> 01:22:50,071
SYSTEM, UNDERSTANDABLY, RIGHT?

2080
01:22:50,071 --> 01:22:53,174
SO, WE HAVE REALLY NOW BECOMING

2081
01:22:53,174 --> 01:22:54,375
VERY SOPHISTICATED IN

2082
01:22:54,375 --> 01:22:55,777
UNDERSTANDING CIRCUITS, FOR

2083
01:22:55,777 --> 01:22:58,747
EXAMPLE, IN THE BRAIN THAT

2084
01:22:58,747 --> 01:23:01,583
MEDIATE THE DEVELOPMENT OF

2085
01:23:01,583 --> 01:23:03,785
CHRONIC PAIN.

2086
01:23:03,785 --> 01:23:06,221
CENTRAL SENSITIZATION, FOR

2087
01:23:06,221 --> 01:23:06,654
EXAMPLE, PERIPHERAL

2088
01:23:06,654 --> 01:23:09,057
SENSITIZATION, ALSO A LOT OF

2089
01:23:09,057 --> 01:23:09,824
EMOTIONAL MECHANISMS TIED TO

2090
01:23:09,824 --> 01:23:16,798
PARTS OF THE BRAIN THAT REGULATE

2091
01:23:16,798 --> 01:23:18,233
OUR EMOTIONS, AMYGDALA,

2092
01:23:18,233 --> 01:23:19,801
PREFRONTAL CORTEX, THAT TIE PAIN

2093
01:23:19,801 --> 01:23:21,202
WITH SUFFERING, THE SUFFERING

2094
01:23:21,202 --> 01:23:23,104
COMPONENT OF PAIN THAT PEOPLE --

2095
01:23:23,104 --> 01:23:24,272
THAT AFFECTS PEOPLE SO MUCH.

2096
01:23:24,272 --> 01:23:27,442
THAT'S WHY I CALL THIS THE

2097
01:23:27,442 --> 01:23:28,309
NEUROPSYCHOSOCIAL ENVIRONMENT OF

2098
01:23:28,309 --> 01:23:28,543
PAIN.

2099
01:23:28,543 --> 01:23:31,679
WE'RE VERY GOOD AT THAT.

2100
01:23:31,679 --> 01:23:34,983
AND A LOT OF MEASURES WE USE

2101
01:23:34,983 --> 01:23:37,285
WHEN WE DO LARGE CLINICAL

2102
01:23:37,285 --> 01:23:39,120
STUDIES OF PAIN ARE IN THIS

2103
01:23:39,120 --> 01:23:39,587
SPACE, RIGHT?

2104
01:23:39,587 --> 01:23:41,322
THIS IS AN EXAMPLE OF THE

2105
01:23:41,322 --> 01:23:43,391
MEASURES THAT ARE ON A VERY

2106
01:23:43,391 --> 01:23:46,995
IMPORTANT STUDY OF PAIN, THE

2107
01:23:46,995 --> 01:23:47,996
ACUTE TO CHRONIC PAIN

2108
01:23:47,996 --> 01:23:49,464
TRANSITIONING IS A COMMON FUND

2109
01:23:49,464 --> 01:23:50,331
STUDY ONGOING RIGHT NOW.

2110
01:23:50,331 --> 01:23:53,401
YOU CAN SEE THE KINDS OF

2111
01:23:53,401 --> 01:23:55,370
MEASUREMENTS.

2112
01:23:55,370 --> 01:23:56,371
PATIENT-REPORTED OUTCOMES, FOR

2113
01:23:56,371 --> 01:23:57,705
EXAMPLE, MOOD, AFFECT, SLEEP,

2114
01:23:57,705 --> 01:23:59,340
COGNITIVE FUNCTION, ET CETERA.

2115
01:23:59,340 --> 01:24:01,409
NEURO IMAGING LOOKING AT THE

2116
01:24:01,409 --> 01:24:02,143
BRAIN, QUANTITATIVE SENSORY

2117
01:24:02,143 --> 01:24:05,580
TESTING, THESE ARE ALL IN IN A

2118
01:24:05,580 --> 01:24:09,384
SORT OF NEUROPSYCHOSOLE  --

2119
01:24:09,384 --> 01:24:10,051
SOCIAL SPACE.

2120
01:24:10,051 --> 01:24:13,855
AND ON THE LEFT-HAND CORNER IS

2121
01:24:13,855 --> 01:24:14,189
OMICS.

2122
01:24:14,189 --> 01:24:15,523
THESE ARE CUTTING EDGE

2123
01:24:15,523 --> 01:24:16,724
MEASUREMENTS TYPICALLY IN A

2124
01:24:16,724 --> 01:24:18,693
BLOOD SAMPLE, IN THIS CASE, AND

2125
01:24:18,693 --> 01:24:21,429
A LOT OF LARGE SCALE STUDIES OF

2126
01:24:21,429 --> 01:24:23,932
PAIN USE VERY MUCH THESE TYPES

2127
01:24:23,932 --> 01:24:26,901
OF MEASURES, OPERA STUDY WAS AN

2128
01:24:26,901 --> 01:24:28,303
IMPORTANT STUDY OF

2129
01:24:28,303 --> 01:24:29,070
TEMPOROMANDIBULAR PAIN THAT

2130
01:24:29,070 --> 01:24:31,072
STARTED IN 2007, VERY MUCH

2131
01:24:31,072 --> 01:24:33,241
FOLLOWS A SIMILAR BLUEPRINT.

2132
01:24:33,241 --> 01:24:35,743
AND SO WHAT I'M GOING TO BE

2133
01:24:35,743 --> 01:24:37,278
TALKING ABOUT IS THE IDEA THAT

2134
01:24:37,278 --> 01:24:40,782
WHEN WE DO IT THIS WAY, RIGHT,

2135
01:24:40,782 --> 01:24:42,617
WE HAVE OUR NEUROPSYCHOSOCIAL

2136
01:24:42,617 --> 01:24:44,485
ENVIRONMENT AND WE HAVE THE --

2137
01:24:44,485 --> 01:24:47,555
WHAT WE LOOKING AT THIS IN THE

2138
01:24:47,555 --> 01:24:48,756
PERIPHERY IS VERY MUCH SYSTEMIC,

2139
01:24:48,756 --> 01:24:50,291
WHEN WE LOOK AT SOMETHING THAT'S

2140
01:24:50,291 --> 01:24:55,864
IN A BLOOD SAMPLE IT'S REALLY IN

2141
01:24:55,864 --> 01:24:58,833
KIND OF A DIFFUSE I CALL IT

2142
01:24:58,833 --> 01:25:02,003
SWIMMING AROUND TYPE OF QUALITY 

2143
01:25:02,003 --> 01:25:04,639
WHERE WE DON'T REALLY KNOW WHERE

2144
01:25:04,639 --> 01:25:05,840
THESE MOLECULES ACTUALLY ARE.

2145
01:25:05,840 --> 01:25:08,343
WE CAN MEASURE THEM IN THE BLOOD

2146
01:25:08,343 --> 01:25:09,310
BUT THEY GO EVERYWHERE, RIGHT IN

2147
01:25:09,310 --> 01:25:11,746
THE WHAT I'M GOING TO ARGUE IS

2148
01:25:11,746 --> 01:25:14,682
WHAT NEEDS TO COMPLETE THIS

2149
01:25:14,682 --> 01:25:16,618
PICTURE IS TO UNDERSTAND WHERE

2150
01:25:16,618 --> 01:25:18,519
IN THE TISSUES ALL OF THESE

2151
01:25:18,519 --> 01:25:21,022
OMICS THAT WE'RE MEASURING ARE

2152
01:25:21,022 --> 01:25:23,224
ACTUALLY ACTING ON THE TISSUES

2153
01:25:23,224 --> 01:25:24,559
AND INTERACTING WITH BOTH THE

2154
01:25:24,559 --> 01:25:25,526
TISSUES AND NERVOUS SYSTEM.

2155
01:25:25,526 --> 01:25:27,695
SO I'M GOING TO USE THIS AS AN

2156
01:25:27,695 --> 01:25:28,796
EXAMPLE, A KNEE JOINT.

2157
01:25:28,796 --> 01:25:34,569
SOMEBODY WHO HAS PAIN IN THEIR

2158
01:25:34,569 --> 01:25:34,769
KNEE.

2159
01:25:34,769 --> 01:25:36,371
WE SAY 20, 30 YEARS AGO SOMEBODY

2160
01:25:36,371 --> 01:25:38,773
WOULD HAVE PAIN IN THEIR KNEE,

2161
01:25:38,773 --> 01:25:40,508
THE IDEA WAS FIX THE KNEE,

2162
01:25:40,508 --> 01:25:41,276
RIGHT?

2163
01:25:41,276 --> 01:25:44,112
THIS WAS THE ORTHOPEDIC

2164
01:25:44,112 --> 01:25:45,680
APPROACH, THAT WAS KIND OF

2165
01:25:45,680 --> 01:25:48,383
DISAPPOINTING IN A LOT OF WAYS.

2166
01:25:48,383 --> 01:25:51,452
PEOPLE AT TIMES WOULD FIND

2167
01:25:51,452 --> 01:25:52,120
PEOPLE WITH VERY BAD-LOOKING

2168
01:25:52,120 --> 01:25:53,621
X-RAYS WITH NO PAIN OR SOMEBODY

2169
01:25:53,621 --> 01:25:57,926
WHO HAD PAIN BUT DID NOT HAVE

2170
01:25:57,926 --> 01:25:58,593
DEMONSTRABLE ABNORMALITIES

2171
01:25:58,593 --> 01:25:59,727
RADIOLOGICALLY.

2172
01:25:59,727 --> 01:26:00,995
SO THERE WAS A SHIFT TOWARDS

2173
01:26:00,995 --> 01:26:01,930
REALLY PAYING MORE ATTENTION TO

2174
01:26:01,930 --> 01:26:03,731
WHAT'S GOING ON IN THE NERVOUS

2175
01:26:03,731 --> 01:26:04,065
SYSTEM.

2176
01:26:04,065 --> 01:26:06,801
THAT HAS RESULTED IN A GREAT

2177
01:26:06,801 --> 01:26:08,903
DEAL OF UNDERSTANDING IN THE

2178
01:26:08,903 --> 01:26:09,871
NEUROEFFECTIVE COMPONENTS OF

2179
01:26:09,871 --> 01:26:10,672
PAIN.

2180
01:26:10,672 --> 01:26:12,740
BUT I WOULD ARGUE THAT THERE'S A

2181
01:26:12,740 --> 01:26:14,409
LOT STILL THAT WE DON'T

2182
01:26:14,409 --> 01:26:17,211
UNDERSTAND ABOUT THE ROLE OF

2183
01:26:17,211 --> 01:26:17,912
THESE PERIPHERAL MUSCULOSKELETAL

2184
01:26:17,912 --> 01:26:21,282
TISSUES IN, FOR EXAMPLE, KNEE

2185
01:26:21,282 --> 01:26:22,450
PAIN, PERHAPS BECAUSE WE WEREN'T

2186
01:26:22,450 --> 01:26:24,085
MAYBE LOOKING IN THE RIGHT

2187
01:26:24,085 --> 01:26:25,753
PLACES AND/OR MAYBE WE DIDN'T

2188
01:26:25,753 --> 01:26:27,221
HAVE THE RIGHT TOOLS TO LOOK.

2189
01:26:27,221 --> 01:26:28,423
I THINK WHAT I'M GOING TO

2190
01:26:28,423 --> 01:26:31,426
SUGGEST IS WE NEED TO KEEP

2191
01:26:31,426 --> 01:26:31,659
LOOKING.

2192
01:26:31,659 --> 01:26:32,293
AND UNDERSTANDING BETTER WHAT

2193
01:26:32,293 --> 01:26:33,728
GOES ON IN THE PERIPHERAL

2194
01:26:33,728 --> 01:26:36,364
TISSUES CAN HELP US UNDERSTAND A

2195
01:26:36,364 --> 01:26:37,398
WHOLE PICTURE OF PAIN, INCLUDING

2196
01:26:37,398 --> 01:26:39,100
I WOULD ARGUE WHAT'S GOING ON IN

2197
01:26:39,100 --> 01:26:39,968
THE NERVOUS SYSTEM.

2198
01:26:39,968 --> 01:26:42,971
THAT WHY I THINK IT'S IMPORTANT

2199
01:26:42,971 --> 01:26:45,773
WE REALLY LOOK IN A MORE

2200
01:26:45,773 --> 01:26:46,474
HOLISTIC FASHION.

2201
01:26:46,474 --> 01:26:50,712
SO, WHAT ARE THE REASONS WHY

2202
01:26:50,712 --> 01:26:52,680
THESE TISSUES ARE IMPORTANT, WE

2203
01:26:52,680 --> 01:26:54,115
THINK ARE IMPORTANT, IS BECAUSE

2204
01:26:54,115 --> 01:26:55,416
WHEN WE THINK ABOUT SOMEBODY WHO

2205
01:26:55,416 --> 01:26:57,585
HAS PAIN IN THEIR KNEE WE

2206
01:26:57,585 --> 01:27:00,555
USUALLY THINK ABOUT PAIN COMING

2207
01:27:00,555 --> 01:27:01,322
FROM THE ARTICULATION,

2208
01:27:01,322 --> 01:27:03,157
CARTILAGE, WHAT'S INSIDE THE

2209
01:27:03,157 --> 01:27:04,692
JOINT, EITHER THE CARTILAGE IF

2210
01:27:04,692 --> 01:27:10,064
SOMEBODY HAS OSTEOARTHRITIS OR

2211
01:27:10,064 --> 01:27:10,765
SYNOVIUM WITH INFLAMMATORY

2212
01:27:10,765 --> 01:27:12,066
ARTHRITIS BUT OTHER TISSUES ARE

2213
01:27:12,066 --> 01:27:13,701
PARTS OF THIS JOINT ON THE

2214
01:27:13,701 --> 01:27:15,336
OUTSIDE OF THE JOINT.

2215
01:27:15,336 --> 01:27:18,506
WHAT WE CALL THE PERIARTICULAR

2216
01:27:18,506 --> 01:27:21,142
TISSUE, CAPSULES, JOINT CAPSULES

2217
01:27:21,142 --> 01:27:22,543
, LIGAMENTS, TENDONS, THE

2218
01:27:22,543 --> 01:27:23,311
MUSCLES, FASCIA, CONNECTIVE

2219
01:27:23,311 --> 01:27:24,979
TISSUE AROUND THOSE MUSCLES THAT

2220
01:27:24,979 --> 01:27:25,947
INSERT INTO THE CONNECTIVE

2221
01:27:25,947 --> 01:27:27,382
TISSUE OF THE CAPSULE.

2222
01:27:27,382 --> 01:27:30,018
WE HAVE KNOWN FOR SOME YEARS NOW

2223
01:27:30,018 --> 01:27:33,087
THAT THESE TISSUES ARE

2224
01:27:33,087 --> 01:27:34,288
ENERVATED, EXTENSIVELY, WITH

2225
01:27:34,288 --> 01:27:37,025
SMALL DIAMETER FIBERS THAT WE

2226
01:27:37,025 --> 01:27:39,427
KNOW ARE NOCICEPTORS.

2227
01:27:39,427 --> 01:27:44,032
SO, WE ALSO KNOW THAT PAIN IS A

2228
01:27:44,032 --> 01:27:45,133
CONVERSATION, BACK AND FORTH,

2229
01:27:45,133 --> 01:27:46,667
BETWEEN NERVOUS SYSTEM AND

2230
01:27:46,667 --> 01:27:50,571
PARAGRAPH  -- PERIPHERAL

2231
01:27:50,571 --> 01:27:52,006
TISSUES.

2232
01:27:52,006 --> 01:27:55,743
WHEN A C FIBER IS ACTIVATED IT

2233
01:27:55,743 --> 01:27:58,913
DUMPS SUBSTANCE P INTO THE

2234
01:27:58,913 --> 01:28:03,618
TISSUE WHICH CONTINUES, WHICH

2235
01:28:03,618 --> 01:28:05,153
INCREASES THE INFLAMMATORY

2236
01:28:05,153 --> 01:28:05,953
RESPONSE, NEUROGENIC

2237
01:28:05,953 --> 01:28:06,287
INFLAMMATION.

2238
01:28:06,287 --> 01:28:07,255
WHEN YOU HAVE SOMETHING LIKE

2239
01:28:07,255 --> 01:28:09,891
THAT GOING ON BY DEFINITION YOU

2240
01:28:09,891 --> 01:28:10,992
HAVE THAT GOING ON IN THE

2241
01:28:10,992 --> 01:28:14,695
TISSUE, THE OTHER THING THAT

2242
01:28:14,695 --> 01:28:16,764
HAPPENS IN TISSUES IS

2243
01:28:16,764 --> 01:28:20,501
INFLAMMATORY RESPONSES SUCH AS

2244
01:28:20,501 --> 01:28:31,045
NEUROGENIC ARE AUGMENTED BY FAT.

2245
01:28:31,512 --> 01:28:32,980
ADIPOSE TISSUE IS INFLAMMATORY

2246
01:28:32,980 --> 01:28:35,149
ESPECIALLY IN EXCESS, THAT

2247
01:28:35,149 --> 01:28:36,350
CONTRIBUTE TO THE INFLAMMATORY

2248
01:28:36,350 --> 01:28:36,617
RESPONSE.

2249
01:28:36,617 --> 01:28:38,786
WE KNOW ALL THESE TISSUES HAVE A

2250
01:28:38,786 --> 01:28:40,421
VERY IMPORTANT MECHANICAL AND

2251
01:28:40,421 --> 01:28:41,956
STRUCTURAL RELATIONSHIP TO EACH

2252
01:28:41,956 --> 01:28:44,092
OTHER, ESPECIALLY IN THE

2253
01:28:44,092 --> 01:28:46,761
MUSCULOSKELETAL SYSTEM, WHERE A

2254
01:28:46,761 --> 01:28:51,699
LOT OF THESE STRUCTURES HAVE

2255
01:28:51,699 --> 01:28:52,467
MECHANICAL RELATIONSHIP, THEIR

2256
01:28:52,467 --> 01:28:53,901
MOVEMENTS OCCUR IN A SHEER

2257
01:28:53,901 --> 01:28:56,104
PLANE, LIKE THIS, THEY MOVE ONE

2258
01:28:56,104 --> 01:28:58,172
RELATIVE TO THE OTHER, AND AS

2259
01:28:58,172 --> 01:29:01,776
REPRESENTED HERE IN THIS CARTOON

2260
01:29:01,776 --> 01:29:04,078
YOU HAVE LAYERS IN GENE THE

2261
01:29:04,078 --> 01:29:06,380
JOINT CAPSULE AND THE PURPLE

2262
01:29:06,380 --> 01:29:07,381
WOULD BE THE LIGAMENT, NEXT TO

2263
01:29:07,381 --> 01:29:07,748
IT.

2264
01:29:07,748 --> 01:29:13,721
WHERE THERE'S A LAYER OF LOOSE

2265
01:29:13,721 --> 01:29:15,022
CONNECTIVE TISSUE WHERE NERVE

2266
01:29:15,022 --> 01:29:16,891
FIBBERS ARE POSITIONED.

2267
01:29:16,891 --> 01:29:19,727
WHEN YOU MOVE THE KNEE THE

2268
01:29:19,727 --> 01:29:21,596
MOVEMENT IS BETWEEN THOSE TWO

2269
01:29:21,596 --> 01:29:23,464
LAYERS, NOT ONE LAYER

2270
01:29:23,464 --> 01:29:24,866
STRETCHING, BECAUSE EACH LAYER

2271
01:29:24,866 --> 01:29:29,137
ONLY STRETCHES ABOUT 10%  BUT

2272
01:29:29,137 --> 01:29:30,438
MOVEMENT BETWEEN LAYERS CAN BE

2273
01:29:30,438 --> 01:29:32,340
AS MUCH AS 100%.

2274
01:29:32,340 --> 01:29:34,775
THIS IS A BIG SOURCE OF

2275
01:29:34,775 --> 01:29:35,042
MOVEMENT.

2276
01:29:35,042 --> 01:29:37,145
I'LL PLAY A MOVIE THAT SHOWS

2277
01:29:37,145 --> 01:29:37,378
THAT.

2278
01:29:37,378 --> 01:29:39,680
YOU CAN HAVE -- THE WAY -- I

2279
01:29:39,680 --> 01:29:40,982
HOPE YOU CAN SEE THIS.

2280
01:29:40,982 --> 01:29:43,718
AT THE TOP WHITE LAYERS, TWO OR

2281
01:29:43,718 --> 01:29:45,820
THREE LAYERS ADJACENT OF FASCIA,

2282
01:29:45,820 --> 01:29:47,555
CONNECTIVE TISSUE, YOU CAN SEE A

2283
01:29:47,555 --> 01:29:49,757
LOT OF SHEER PLANE MOBILITY,

2284
01:29:49,757 --> 01:29:51,292
DARK LAYERS IN BETWEEN THE

2285
01:29:51,292 --> 01:29:51,659
LAYERS.

2286
01:29:51,659 --> 01:29:55,163
WHERE THE LAYERS ARE MOVING IN

2287
01:29:55,163 --> 01:29:55,496
SHEER.

2288
01:29:55,496 --> 01:29:56,464
DO YOU SEE THIS?

2289
01:29:56,464 --> 01:30:00,835
I'M GOING TO PLAY ANOTHER

2290
01:30:00,835 --> 01:30:01,836
EXAMPLE OF WHERE THERE'S NOT AS

2291
01:30:01,836 --> 01:30:04,705
MUCH MOVEMENT. 

2292
01:30:04,705 --> 01:30:07,208
AND WE KNOW THIS HAPPENS, I HOPE

2293
01:30:07,208 --> 01:30:08,709
YOU CAN APPRECIATE HERE, THESE

2294
01:30:08,709 --> 01:30:10,344
LAYERS ARE NOT AS MOBILE.

2295
01:30:10,344 --> 01:30:11,579
THEY ARE REALLY LOOKING LIKE

2296
01:30:11,579 --> 01:30:12,680
THEY ARE STUCK TOGETHER.

2297
01:30:12,680 --> 01:30:14,415
IN FACT THIS IS WHAT HAPPENS.

2298
01:30:14,415 --> 01:30:16,050
WHEN PEOPLE HAVE AN INJURY, WHAT

2299
01:30:16,050 --> 01:30:18,553
HAPPENS IS THAT YOU GET

2300
01:30:18,553 --> 01:30:19,453
ADHESIONS BETWEEN THE LAYERS,

2301
01:30:19,453 --> 01:30:22,924
THIS IS A VERY WELL KNOWN

2302
01:30:22,924 --> 01:30:24,158
PHENOMENON WITH INFLAMMATION,

2303
01:30:24,158 --> 01:30:26,394
CAUSES FIBROTIC PROCESS WITH

2304
01:30:26,394 --> 01:30:27,328
LAYERS NO LONGER INDEPENDENT

2305
01:30:27,328 --> 01:30:27,762
MOTION.

2306
01:30:27,762 --> 01:30:30,164
YOU CAN IMAGINE WHAT THAT DOES

2307
01:30:30,164 --> 01:30:31,265
TO A LITTLE NOCICEPTOR THAT'S IN

2308
01:30:31,265 --> 01:30:34,569
THE MIDDLE OF THESE LAYERS.

2309
01:30:34,569 --> 01:30:35,970
IT AFFECTS ITS FUNCTION.

2310
01:30:35,970 --> 01:30:37,471
SO, THE OTHER THING THAT'S

2311
01:30:37,471 --> 01:30:40,675
IMPORTANT TO REALIZE IS THAT

2312
01:30:40,675 --> 01:30:41,642
INFLAMMATORY RESPONSES ARE NOT

2313
01:30:41,642 --> 01:30:44,045
JUST ALL OVER THE PLACE.

2314
01:30:44,045 --> 01:30:45,246
THEY ARE SPATIALLY ORGANIZED.

2315
01:30:45,246 --> 01:30:49,617
THIS IS AN EXAMPLE SHOWING THE 

2316
01:30:49,617 --> 01:30:54,121
GREEN STAINING FOR ARGINASE, A

2317
01:30:54,121 --> 01:30:55,423
MARKER OF MACROPHAGES,

2318
01:30:55,423 --> 01:30:56,657
PRO-RESOLUTION MACROPHAGES THAT

2319
01:30:56,657 --> 01:30:58,159
HELP RESOLVE INFLAMMATION.

2320
01:30:58,159 --> 01:30:59,894
AND IN THIS EXAMPLE HERE I HOPE

2321
01:30:59,894 --> 01:31:03,097
YOU CAN SEE THIS IS ARGINASE,

2322
01:31:03,097 --> 01:31:03,965
GREEN STAINING, VERY

2323
01:31:03,965 --> 01:31:05,066
SPECIFICALLY LOCALIZED TO ONE

2324
01:31:05,066 --> 01:31:06,934
LAYER OF TISSUE WHICH HAPPENS TO

2325
01:31:06,934 --> 01:31:10,204
BE THE SHEER PLANE INTERFACE 

2326
01:31:10,204 --> 01:31:11,973
BETWEEN THE TWO LAYERS.

2327
01:31:11,973 --> 01:31:14,909
NOW, WE SOMETIMES TALK ABOUT

2328
01:31:14,909 --> 01:31:15,876
INFLAMMATORY SOUP.

2329
01:31:15,876 --> 01:31:18,112
I WILL SUGGEST THAT WE SHOULD

2330
01:31:18,112 --> 01:31:20,748
START TALKING ABOUT INFLAMMATORY

2331
01:31:20,748 --> 01:31:22,149
SANDWICHES, OKAY, INSTEAD.

2332
01:31:22,149 --> 01:31:26,087
WHERE YOU HAVE THESE LAYERS THAT

2333
01:31:26,087 --> 01:31:27,722
HAVE A SAY HOW THE INFLAMMATION

2334
01:31:27,722 --> 01:31:29,790
IS GOING TO BE ORGANIZED.

2335
01:31:29,790 --> 01:31:32,226
AND WHEN YOU HAVE DIFFERENT

2336
01:31:32,226 --> 01:31:36,264
KINDS OF SANDWICHES, IT AFFECT

2337
01:31:36,264 --> 01:31:37,398
MIGHT AFFECT THE MOVEMENT.

2338
01:31:37,398 --> 01:31:38,966
ON THE LEFT A BUNCH OF

2339
01:31:38,966 --> 01:31:40,401
MAYONNAISE, A LOT OF MOVEMENT

2340
01:31:40,401 --> 01:31:41,302
BETWEEN THE TISSUES.

2341
01:31:41,302 --> 01:31:43,571
ON THE RIGHT YOU HAVE THICK

2342
01:31:43,571 --> 01:31:45,673
PEANUT BUTTER THAT MIGHT NOT BE

2343
01:31:45,673 --> 01:31:47,742
SO GOOD AT FAVORING MOTION.

2344
01:31:47,742 --> 01:31:50,711
MORE LIKE ACTING LIKE A GLUE.

2345
01:31:50,711 --> 01:31:53,981
NOW, IF YOU HAD A NOCICEPTOR

2346
01:31:53,981 --> 01:31:56,083
THAT IS IN THIS LAYER, EITHER

2347
01:31:56,083 --> 01:31:58,586
MAYONNAISE OR GLUE, AND YOU HAVE

2348
01:31:58,586 --> 01:32:01,422
A LITTLE ION CHANNEL THAT IS ON

2349
01:32:01,422 --> 01:32:03,291
THE LEFT HERE PICTURED, THAT

2350
01:32:03,291 --> 01:32:04,692
OPENS OR CLOSES, RIGHT, IN

2351
01:32:04,692 --> 01:32:06,127
RESPONSE TO MECHANICAL FORCE AS

2352
01:32:06,127 --> 01:32:11,265
WE KNOW MANY ION CHANNELS DO.

2353
01:32:11,265 --> 01:32:14,101
AND BY WAIT WE HAVE SOME ION

2354
01:32:14,101 --> 01:32:16,203
CHANNELS WHICH WE KNOW ARE

2355
01:32:16,203 --> 01:32:17,238
SPECIFICALLY OPEN IN RESPONSE TO

2356
01:32:17,238 --> 01:32:22,176
A FORCE BUT THERE ARE OTHER

2357
01:32:22,176 --> 01:32:26,147
CHANNELS LIKE, FOR EXAMPLE,

2358
01:32:26,147 --> 01:32:27,581
VOLTAGE GATED CHANNELS, THEY

2359
01:32:27,581 --> 01:32:34,255
ALSO EVEN THOUGH FORCE IS NOT

2360
01:32:34,255 --> 01:32:36,090
THEIR PRIMARY STIMULUS FOR

2361
01:32:36,090 --> 01:32:37,858
OPENING, FORCE CAN MODERATE THE

2362
01:32:37,858 --> 01:32:39,794
OPENING OF THESE CHANNELS.

2363
01:32:39,794 --> 01:32:41,329
THE REASON THIS MATTERS HERE IS

2364
01:32:41,329 --> 01:32:43,097
BECAUSE IMAGINE NOW YOU HAVE AN

2365
01:32:43,097 --> 01:32:46,167
ION CHANNEL THAT IS SITUATED IN

2366
01:32:46,167 --> 01:32:49,737
A LAYER THAT IS MORE VERSUS LESS

2367
01:32:49,737 --> 01:32:49,937
STIFF.

2368
01:32:49,937 --> 01:32:51,839
IF YOU HAVE THE SAME WEIGHT ON

2369
01:32:51,839 --> 01:32:53,908
TWO RUBBER BANDS, ONE MORE

2370
01:32:53,908 --> 01:32:55,443
STIFF, THE STIFFER ONE WILL NOT

2371
01:32:55,443 --> 01:33:02,350
DEFORM AS MUCH.

2372
01:33:02,350 --> 01:33:05,953
WHEN WE THINK ABOUT CHANNEL

2373
01:33:05,953 --> 01:33:08,055
OPENING OR CLOSING TO A FORCE WE

2374
01:33:08,055 --> 01:33:10,491
DON'T KNOW IF IT'S THE FORCE OR

2375
01:33:10,491 --> 01:33:12,226
DEFORMATION OF MEMBRANE, THE

2376
01:33:12,226 --> 01:33:12,960
STRAIN, RIGHT?

2377
01:33:12,960 --> 01:33:14,028
THE RELATIONSHIP BETWEEN THE

2378
01:33:14,028 --> 01:33:15,463
THRUST AND STRAIN VIA THE

2379
01:33:15,463 --> 01:33:17,832
STIFFNESS AS SHOWN ON THE RIGHT.

2380
01:33:17,832 --> 01:33:21,302
SO IF YOU HAVE A CELL WHOSE

2381
01:33:21,302 --> 01:33:22,403
MEMBRANE IS STIFFER, EITHER

2382
01:33:22,403 --> 01:33:25,906
BECAUSE MEMBRANE ITSELF IS 

2383
01:33:25,906 --> 01:33:28,743
STIFFER OR THE OUTER

2384
01:33:28,743 --> 01:33:32,380
EXTRACELLULAR MATRIX IS STIFFER 

2385
01:33:32,380 --> 01:33:34,682
IN THE CASE OF FIBROTIC OR THE

2386
01:33:34,682 --> 01:33:37,184
INSIDE, COULD AFFECT WHETHER THE

2387
01:33:37,184 --> 01:33:39,387
CHANNEL IS OPEN OR NOT.

2388
01:33:39,387 --> 01:33:41,322
THE MECHANICAL ENVIRONMENT

2389
01:33:41,322 --> 01:33:42,990
SURROUNDING THE NOCICEPTOR IS

2390
01:33:42,990 --> 01:33:43,858
IMPORTANT.

2391
01:33:43,858 --> 01:33:45,426
THAT'S WHY I'M THINKING, I'M

2392
01:33:45,426 --> 01:33:47,728
SAYING WE NEED TO UNDERSTAND

2393
01:33:47,728 --> 01:33:49,029
THIS WHOLE RELATIONSHIP OF WHAT

2394
01:33:49,029 --> 01:33:52,633
I CALL THE PERIPHERAL TISSUE

2395
01:33:52,633 --> 01:33:55,469
ENVIRONMENT THAT HAS THIS

2396
01:33:55,469 --> 01:33:57,471
METABOLIC STRUCTURAL AND

2397
01:33:57,471 --> 01:33:58,439
MECHANICAL COMPONENT, ALL

2398
01:33:58,439 --> 01:33:58,906
RELATED.

2399
01:33:58,906 --> 01:34:00,674
AND THEY ALL WORK TOGETHER.

2400
01:34:00,674 --> 01:34:02,476
AND UNDERSTANDING ALL OF THAT

2401
01:34:02,476 --> 01:34:06,313
WILL HELP US UNDERSTAND PAIN

2402
01:34:06,313 --> 01:34:06,547
BETTER.

2403
01:34:06,547 --> 01:34:08,048
NOW, THE RELATIONSHIP BETWEEN

2404
01:34:08,048 --> 01:34:10,251
THIS PERIPHERAL TISSUE

2405
01:34:10,251 --> 01:34:11,085
ENVIRONMENT AND THE

2406
01:34:11,085 --> 01:34:12,553
NEUROPSYCHOSOCIAL ENVIRONMENT IS

2407
01:34:12,553 --> 01:34:13,854
OF COURSE EXTREMELY IMPORTANT,

2408
01:34:13,854 --> 01:34:14,622
RIGHT?

2409
01:34:14,622 --> 01:34:17,258
WHAT HAPPENS WHEN PEOPLE HAVE

2410
01:34:17,258 --> 01:34:18,926
PAIN IS THAT IT AFFECTS THEIR

2411
01:34:18,926 --> 01:34:20,094
BEHAVIOR, HOW THEY MOVE.

2412
01:34:20,094 --> 01:34:21,429
PEOPLE DO NOT LIKE MOVING OF

2413
01:34:21,429 --> 01:34:23,497
COURSE WHEN IT'S GOING TO HURT

2414
01:34:23,497 --> 01:34:27,468
TO MOVE SO THEY BECOME -- THEY

2415
01:34:27,468 --> 01:34:33,374
RESTRICT MOVEMENT, 

2416
01:34:33,374 --> 01:34:34,008
K INESIAPHOBIA, AGGRAVATED BY

2417
01:34:34,008 --> 01:34:34,708
STRESS, POOR SLEEP.

2418
01:34:34,708 --> 01:34:38,813
YOU CAN SEE THAT KIND OF LINK

2419
01:34:38,813 --> 01:34:39,847
BETWEEN THE PERIPHERAL TISSUES

2420
01:34:39,847 --> 01:34:41,248
WHICH THAT WHOLE MECHANICAL

2421
01:34:41,248 --> 01:34:43,117
ENVIRONMENT SURROUNDING THE

2422
01:34:43,117 --> 01:34:45,519
JOINTS, MUSCLES, FASCIA, ALL

2423
01:34:45,519 --> 01:34:47,054
THESE, CAMERA RECEPTORS AND THE

2424
01:34:47,054 --> 01:34:48,255
BEHAVIOR OF THE PERSON.

2425
01:34:48,255 --> 01:34:51,892
OF COURSE, ALL OF THIS IS BATHED

2426
01:34:51,892 --> 01:34:55,029
IN THE SYSTEMIC ENVIRONMENT.

2427
01:34:55,029 --> 01:34:59,099
SO IT'S A BIG COMPLICATED THING.

2428
01:34:59,099 --> 01:35:00,601
THE GOOD NEWS, AND WE ARE

2429
01:35:00,601 --> 01:35:02,803
MISSING A LOT OF PIECES OF THE

2430
01:35:02,803 --> 01:35:03,037
PUZZLE.

2431
01:35:03,037 --> 01:35:05,105
WE DON'T STUDY IT VERY MUCH.

2432
01:35:05,105 --> 01:35:07,875
THE GOOD NEWS THOUGH IS THE HEAL

2433
01:35:07,875 --> 01:35:10,277
INITIATIVE STARTED TO DO THAT.

2434
01:35:10,277 --> 01:35:13,047
AND TWO YEARS AGO WE FUNDED A

2435
01:35:13,047 --> 01:35:16,317
WONDERFUL PROGRAM WHICH WAS

2436
01:35:16,317 --> 01:35:18,719
UNIQUE AND NEW, IN DEVELOPING

2437
01:35:18,719 --> 01:35:21,121
QUANTITATIVE IMAGING AND OTHER

2438
01:35:21,121 --> 01:35:22,323
MARKERS OF MYOFASCIAL TISSUES

2439
01:35:22,323 --> 01:35:23,891
WHICH WE BADLY NEEDED BECAUSE UP

2440
01:35:23,891 --> 01:35:26,727
UNTIL NOW WE DIDN'T REALLY HAVE

2441
01:35:26,727 --> 01:35:28,696
ANY IMAGING OR OTHER TYPES OF

2442
01:35:28,696 --> 01:35:29,663
MEASURES OF LOOKING AT THESE

2443
01:35:29,663 --> 01:35:30,331
TISSUES AT ALL.

2444
01:35:30,331 --> 01:35:35,803
THEY WERE KIND OF IN THE DARK.

2445
01:35:35,803 --> 01:35:37,238
STANDARD MRI, FOR EXAMPLE, DON'T

2446
01:35:37,238 --> 01:35:38,205
VISUALIZE SOFT TISSUES.

2447
01:35:38,205 --> 01:35:40,374
THEY ARE TUNED TO LOOK AT HARD

2448
01:35:40,374 --> 01:35:41,175
TISSUES, CARTILAGE, BONE, ET

2449
01:35:41,175 --> 01:35:41,642
CETERA.

2450
01:35:41,642 --> 01:35:44,111
YOU DON'T HAVE VERY GOOD

2451
01:35:44,111 --> 01:35:46,981
CONTRAST, FOR EXAMPLE, BETWEEN

2452
01:35:46,981 --> 01:35:47,715
MUSCLE AND SURROUNDING

2453
01:35:47,715 --> 01:35:52,653
PERIMUSCULAR FASCIA USING

2454
01:35:52,653 --> 01:35:52,987
STANDARD MRI.

2455
01:35:52,987 --> 01:36:00,227
A LOT OF THESE ARE MECHANICAL,

2456
01:36:00,227 --> 01:36:04,298
LOOKING IT'S A TISSUE STIFFNESS,

2457
01:36:04,298 --> 01:36:09,003
MEASURES USING MR SPECTROSCOPY 

2458
01:36:09,003 --> 01:36:10,371
OR MULTI-MODAL ELECTROMYOGRAPHY

2459
01:36:10,371 --> 01:36:11,138
COMBINED WITH IMAGING, ET

2460
01:36:11,138 --> 01:36:12,406
CETERA, SO VERY EXCITING

2461
01:36:12,406 --> 01:36:16,076
PROGRAM, NOW TWO YEARS INTO IT.

2462
01:36:16,076 --> 01:36:19,013
ANOTHER IMPORTANT PROGRAM IS THE

2463
01:36:19,013 --> 01:36:20,781
RE-JOIN INITIATIVE, PART OF

2464
01:36:20,781 --> 01:36:23,717
HEAL, TO LOOK AT SENSORY

2465
01:36:23,717 --> 01:36:24,451
INNERVATION OF DIFFERENT

2466
01:36:24,451 --> 01:36:27,121
EXPONENTS OF THE JOINT I --

2467
01:36:27,121 --> 01:36:30,958
COMPONENTS OF THE JOINT, NOT

2468
01:36:30,958 --> 01:36:36,297
JUST CARTILAGE, THAT ONLY GETS

2469
01:36:36,297 --> 01:36:38,732
ENERVATED, DOES NOT HAVE A

2470
01:36:38,732 --> 01:36:40,935
VASCULAR SUPPLY BUT WHEN IT'S

2471
01:36:40,935 --> 01:36:42,670
INFLAMED IT DOES.

2472
01:36:42,670 --> 01:36:47,041
BUT ALL THESE STRUCTURES AROUND

2473
01:36:47,041 --> 01:36:48,842
THE JOINTS HAVE SENSORY

2474
01:36:48,842 --> 01:36:49,209
INNERVATION.

2475
01:36:49,209 --> 01:36:54,615
WE NEED TO UNDERSTAND HOW THIS

2476
01:36:54,615 --> 01:36:55,049
WORKS.

2477
01:36:55,049 --> 01:36:56,150
MAPPING ALL OF THESE

2478
01:36:56,150 --> 01:37:02,957
INNERVATIONS TO LOOK AT JOINT IN

2479
01:37:02,957 --> 01:37:04,325
A MORE HOLISTIC WAY.

2480
01:37:04,325 --> 01:37:06,093
THE OTHER IMPORTANT PROGRAM IS

2481
01:37:06,093 --> 01:37:08,729
THE BACPAC PROGRAM DEVELOPING

2482
01:37:08,729 --> 01:37:11,031
EXTENSIVE AND COMPREHENSIVE

2483
01:37:11,031 --> 01:37:12,333
MODELS OF BACK PAIN.

2484
01:37:12,333 --> 01:37:16,704
THE NICE THING ABOUT BACPAC,

2485
01:37:16,704 --> 01:37:18,472
ALSO TESTING INTERVENTIONS, THE

2486
01:37:18,472 --> 01:37:20,140
MODELS DEPICTED HERE ARE MEANT

2487
01:37:20,140 --> 01:37:21,442
TO BE ITERATIVE SO THEY CAN

2488
01:37:21,442 --> 01:37:22,643
INCORPORATE NEW KNOWLEDGE AS IT

2489
01:37:22,643 --> 01:37:23,744
COMES ALONG.

2490
01:37:23,744 --> 01:37:26,480
SO WHAT WE'RE PLANNING ON DOING

2491
01:37:26,480 --> 01:37:28,782
IS AS NEW KNOWLEDGE COMES AROUND

2492
01:37:28,782 --> 01:37:30,851
FROM BOTH THE MYOFASCIAL TISSUE

2493
01:37:30,851 --> 01:37:32,586
INITIATIVE AND RE-JOIN ON THE

2494
01:37:32,586 --> 01:37:35,122
JOINT, THEY WILL INFORM THESE

2495
01:37:35,122 --> 01:37:38,292
MODELS, YOU CAN SEE THE FACET

2496
01:37:38,292 --> 01:37:39,927
JOINTS, FOR EXAMPLE, IN THE BACK

2497
01:37:39,927 --> 01:37:43,564
ARE JOINTS THAT HAVE ALL THE

2498
01:37:43,564 --> 01:37:44,765
COMPONENTS OF THE KNEE, FOR

2499
01:37:44,765 --> 01:37:45,966
EXAMPLE, OR OTHER JOINTS, AND SO

2500
01:37:45,966 --> 01:37:47,701
THEY ALL NEED TO BE LOOKED AT IN

2501
01:37:47,701 --> 01:37:49,670
THAT INTEGRATIVE WAY AS WELL.

2502
01:37:49,670 --> 01:38:00,114
AS WELL AS AUTHOR AUTHOR -

2503
01:38:02,549 --> 01:38:06,420
THORACO LUMBAR.

2504
01:38:06,420 --> 01:38:07,621
BY PUTTING THESE PROJECTS

2505
01:38:07,621 --> 01:38:09,023
TOGETHER AND INFORMING EACH

2506
01:38:09,023 --> 01:38:16,463
OTHER WE CAN ARRIVE AT A MORE

2507
01:38:16,463 --> 01:38:18,766
COMPLETE PICTURE OF BACK PAIN.

2508
01:38:18,766 --> 01:38:21,835
THE SECOND GAP OR CHALLENGE THAT

2509
01:38:21,835 --> 01:38:24,138
I WANTED TO DISCUSS IS

2510
01:38:24,138 --> 01:38:25,673
UNDERSTANDING AND SUPPORTING

2511
01:38:25,673 --> 01:38:27,641
ENDOGENOUS PAIN RESOLUTION AND

2512
01:38:27,641 --> 01:38:30,377
THE IDEA IS THAT PERHAPS WHAT

2513
01:38:30,377 --> 01:38:33,547
WE'RE SUGGESTING IS THAT

2514
01:38:33,547 --> 01:38:34,214
UNDERSTANDING BETTER THE

2515
01:38:34,214 --> 01:38:36,483
PERIPHERAL AS WELL AS NERVOUS

2516
01:38:36,483 --> 01:38:37,718
SYSTEM ENVIRONMENT WILL HELP US

2517
01:38:37,718 --> 01:38:38,919
ADDRESS THIS QUESTION.

2518
01:38:38,919 --> 01:38:40,654
SO, WHY IS THAT?

2519
01:38:40,654 --> 01:38:43,724
WHEN WE THINK ABOUT RECOVERING

2520
01:38:43,724 --> 01:38:47,227
FROM ANYTHING, IF ILLNESS, THINK

2521
01:38:47,227 --> 01:38:49,296
COVID, THERE IS A PERIOD THAT

2522
01:38:49,296 --> 01:38:52,232
IT'S KIND OF A DELICATE PERIOD

2523
01:38:52,232 --> 01:38:56,403
WHICH WE USED TO CALL

2524
01:38:56,403 --> 01:38:57,438
CONVALESCENS, WE DON'T USE THAT

2525
01:38:57,438 --> 01:38:58,806
WORD ANYMORE, THE PERIOD OF TIME

2526
01:38:58,806 --> 01:39:00,240
BETWEEN THE END OF THE ILLNESS

2527
01:39:00,240 --> 01:39:02,543
AND FULL RETURN TO HEALTH.

2528
01:39:02,543 --> 01:39:06,380
AND THIS IS A VERY IMPORTANT

2529
01:39:06,380 --> 01:39:07,581
PERIOD WHERE WHEN SOMEBODY DOES

2530
01:39:07,581 --> 01:39:09,883
NOT FULLY RECOVER FROM AN

2531
01:39:09,883 --> 01:39:12,720
ILLNESS, THEN YOU CAN NOW HAVE

2532
01:39:12,720 --> 01:39:13,787
CONTINUED SYMPTOMS THAT COULD

2533
01:39:13,787 --> 01:39:14,588
CONTINUE.

2534
01:39:14,588 --> 01:39:15,889
WE CALL THIS POST-ACUTE

2535
01:39:15,889 --> 01:39:16,323
SYNDROME.

2536
01:39:16,323 --> 01:39:19,059
AND IN THE OLD DAYS IF YOU READ

2537
01:39:19,059 --> 01:39:20,594
NOVELS FROM THE 19th CENTURY,

2538
01:39:20,594 --> 01:39:23,530
PEOPLE PAID A LOT OF ATTENTION

2539
01:39:23,530 --> 01:39:24,865
TO THIS RECOVERY, CONVALESCENT

2540
01:39:24,865 --> 01:39:26,533
PERIOD, BECAUSE WE DIDN'T HAVE

2541
01:39:26,533 --> 01:39:28,602
TREATMENTS WE HAVE NOWADAYS.

2542
01:39:28,602 --> 01:39:30,871
BUT NOW PEOPLE ARE KIND OF LEFT

2543
01:39:30,871 --> 01:39:32,106
TO NAVIGATE THIS DIFFICULT TIME

2544
01:39:32,106 --> 01:39:33,073
ON THEIR OWN.

2545
01:39:33,073 --> 01:39:34,608
BUT YOU CAN SEE PEOPLE PAID A

2546
01:39:34,608 --> 01:39:37,177
LOT OF ATTENTION TO REST, TO

2547
01:39:37,177 --> 01:39:40,748
EXERCISE, TO DIET, ET CETERA.

2548
01:39:40,748 --> 01:39:42,583
SO, IF YOU THINK ABOUT PAIN,

2549
01:39:42,583 --> 01:39:44,918
WHAT IS THE IDEA HERE, HOW DOES

2550
01:39:44,918 --> 01:39:45,853
THIS RELATE TO PAIN?

2551
01:39:45,853 --> 01:39:48,722
WELL, OF COURSE WHEN YOU HAVE

2552
01:39:48,722 --> 01:39:50,591
THIS TRANSITION, SAY SOMEBODY

2553
01:39:50,591 --> 01:39:52,960
HAS SURGERY, OR ACUTE INJURY,

2554
01:39:52,960 --> 01:39:55,062
WHAT DETERMINES WHETHER A PERSON

2555
01:39:55,062 --> 01:39:58,232
WILL EITHER RESOLVE THEIR PAIN

2556
01:39:58,232 --> 01:39:59,333
AND NO LONGER EXPERIENCE PAIN

2557
01:39:59,333 --> 01:40:01,935
AFTER A CERTAIN PERIOD OF TIME

2558
01:40:01,935 --> 01:40:03,937
OR GO ON TO CHRONIC PAIN IS A

2559
01:40:03,937 --> 01:40:05,706
BIG QUESTION, RIGHT?

2560
01:40:05,706 --> 01:40:06,774
SO WHAT ABOUT -- WHAT ARE

2561
01:40:06,774 --> 01:40:08,108
POSSIBLY SOME OF THE FACTORS

2562
01:40:08,108 --> 01:40:10,077
THAT WE WERE JUST LOOKING AT IN

2563
01:40:10,077 --> 01:40:12,813
TERMS OF THE PERIPHERAL TISSUE

2564
01:40:12,813 --> 01:40:14,882
ENVIRONMENT AS WELL AS THE

2565
01:40:14,882 --> 01:40:15,582
NERVOUS SYSTEM ENVIRONMENT

2566
01:40:15,582 --> 01:40:18,819
TOGETHER, COULD CONTRIBUTE TO

2567
01:40:18,819 --> 01:40:19,920
THIS RESOLUTION OF PAIN?

2568
01:40:19,920 --> 01:40:21,989
WE HAVE VERY LITTLE RESEARCH IN

2569
01:40:21,989 --> 01:40:23,857
THIS AREA, AN AREA REALLY TO

2570
01:40:23,857 --> 01:40:25,292
MOVE INTO AND UNDERSTAND BETTER.

2571
01:40:25,292 --> 01:40:28,128
ONE OF THE MECHANISMS MIGHT BE

2572
01:40:28,128 --> 01:40:29,897
THIS KIND OF PERIPHERAL

2573
01:40:29,897 --> 01:40:32,833
REGULATION OF INFLAMMATION

2574
01:40:32,833 --> 01:40:35,102
THROUGH MECHANICAL STIMULATION.

2575
01:40:35,102 --> 01:40:40,040
WE KNOW GENTLE LOW  AMP PLI

2576
01:40:40,040 --> 01:40:41,175
'TUDE STIMULATION CAN PROMOTE

2577
01:40:41,175 --> 01:40:42,009
RESOLUTION, WE NEED TO

2578
01:40:42,009 --> 01:40:48,182
UNDERSTAND HOW CAN PEOPLE DO 

2579
01:40:48,182 --> 01:40:49,917
THAT THEMSELVES THROUGH MOVEMENT

2580
01:40:49,917 --> 01:40:51,251
AND CORRECTLY ENGAGE MOVEMENT IN

2581
01:40:51,251 --> 01:40:53,520
THE RIGHT KIND OF SHEER PLANE

2582
01:40:53,520 --> 01:40:55,522
MOTION THAT IS GOING TO NORTH

2583
01:40:55,522 --> 01:40:57,691
CAUSE FURTHER DAMAGE AND FURTHER

2584
01:40:57,691 --> 01:40:59,159
PAIN BUT EITHER RATHER PROMOTE

2585
01:40:59,159 --> 01:41:02,796
HEALING. 

2586
01:41:02,796 --> 01:41:04,998
AND WHAT ARE OTHER FACTORS USED

2587
01:41:04,998 --> 01:41:06,400
IN CONJUNCTION TO PROMOTE THE

2588
01:41:06,400 --> 01:41:08,702
RESOLUTION OF THE PAIN AND

2589
01:41:08,702 --> 01:41:10,771
HEALING FOR LONG TERM?

2590
01:41:10,771 --> 01:41:16,677
SO JUST KIND OF SOME OF THE KIND

2591
01:41:16,677 --> 01:41:18,312
OF LOW-HANGING FRUIT HERE TO

2592
01:41:18,312 --> 01:41:20,314
INVESTIGATE MIGHT BE EFFECT OF

2593
01:41:20,314 --> 01:41:21,181
STRESS MANAGEMENT DURING

2594
01:41:21,181 --> 01:41:22,716
RECOVERY PERIOD, POSSIBLY VERY

2595
01:41:22,716 --> 01:41:23,483
IMPORTANT.

2596
01:41:23,483 --> 01:41:26,386
SLEEP, AS WELL AS MECHANICAL

2597
01:41:26,386 --> 01:41:29,623
STIMULATION, EITHER FROM POINT

2598
01:41:29,623 --> 01:41:34,528
OF VIEW OF EXERCISES OR MANUALLY

2599
01:41:34,528 --> 01:41:35,529
APPLIED MECHANICAL STIMULATION.

2600
01:41:35,529 --> 01:41:38,165
AND OF COURSE THE IDEA THAT IF

2601
01:41:38,165 --> 01:41:40,234
YOU SUCCESSFULLY RESOLVE PAIN IN

2602
01:41:40,234 --> 01:41:42,202
THE ACUTE AND SUBACUTE STAGE,

2603
01:41:42,202 --> 01:41:45,472
THIS MAY PRESERVE THE HEALTH OF

2604
01:41:45,472 --> 01:41:47,875
THE JOINT IN THE LONG TERM

2605
01:41:47,875 --> 01:41:50,510
BECAUSE WHEN JOINTS DON'T HEAL

2606
01:41:50,510 --> 01:41:52,246
PROPERLY, AND TISSUES STAY

2607
01:41:52,246 --> 01:41:54,581
STUCK, AND DO NOT RESTORE THEIR

2608
01:41:54,581 --> 01:41:56,016
MOBILITY, THIS WILL COMPROMISE

2609
01:41:56,016 --> 01:41:58,385
THE FUNCTION OF THE JOINT GOING

2610
01:41:58,385 --> 01:41:59,720
FORWARD AND PREDISPOSE TO INJURY

2611
01:41:59,720 --> 01:42:01,355
OF THOSE DELICATE SORT OF

2612
01:42:01,355 --> 01:42:02,389
ARTICULAR STRUCTURES.

2613
01:42:02,389 --> 01:42:05,926
SO THE LINK BETWEEN THE

2614
01:42:05,926 --> 01:42:07,160
PERIARTICULAR AND ARTICULAR

2615
01:42:07,160 --> 01:42:08,161
STRUCTURES,

2616
01:42:08,161 --> 01:42:09,029
PATHOPHYSIOLOGYICALLY, IS VERY

2617
01:42:09,029 --> 01:42:09,296
IMPORTANT.

2618
01:42:09,296 --> 01:42:19,840
WE HAD A WORK SOTH  --  WORKSHOP

2619
01:42:23,477 --> 01:42:24,544
LAST YEAR TO ADDRESS THIS, ALSO

2620
01:42:24,544 --> 01:42:31,785
FROM THE POINT OF VIEW OF HEALTH

2621
01:42:31,785 --> 01:42:32,085
RESTORATION.

2622
01:42:32,085 --> 01:42:39,793
VIDEO AVAILABLE ON THE WEBSITE.

2623
01:42:39,793 --> 01:42:40,761
WE'RE GRATEFUL TO THE HEAL

2624
01:42:40,761 --> 01:42:44,164
INITIATIVE TO ALLOW US TO START

2625
01:42:44,164 --> 01:42:46,667
ASKING VERY BIG QUESTIONS, THAT

2626
01:42:46,667 --> 01:42:48,535
EXPAND ACROSS MORE THAN ONE

2627
01:42:48,535 --> 01:42:49,503
ORGAN OR SYSTEM AT A TIME.

2628
01:42:49,503 --> 01:42:53,340
THIS IS WHY IT'S SO IMPORTANT

2629
01:42:53,340 --> 01:42:55,642
THAT WE WORK TOGETHER TO GAIN

2630
01:42:55,642 --> 01:42:56,643
INTEGRATIVE UNDERSTANDING OF

2631
01:42:56,643 --> 01:43:00,447
PERIPHERAL TISSUES AND THEIR

2632
01:43:00,447 --> 01:43:05,819
SENSORY INNERVATION AND

2633
01:43:05,819 --> 01:43:07,487
MUSCULOSKELETAL PLANE, INCLUDING

2634
01:43:07,487 --> 01:43:08,889
BEHAVIOR, SOCIAL, ENVIRONMENTAL

2635
01:43:08,889 --> 01:43:09,589
CONTEXT.

2636
01:43:09,589 --> 01:43:11,091
SOCIETY NEEDS TO SUPPORT ALL OF

2637
01:43:11,091 --> 01:43:15,128
THIS IN TERMS OF BOTH RESEARCH

2638
01:43:15,128 --> 01:43:17,764
BUT ALSO HELPING PATIENTS TO

2639
01:43:17,764 --> 01:43:19,533
RECOVER AND WHICH BRINGS THE

2640
01:43:19,533 --> 01:43:21,702
SECOND POINT, UNDERSTANDING AND

2641
01:43:21,702 --> 01:43:27,074
SUPPORTING ENDOGENOUS PAIN REST 

2642
01:43:27,074 --> 01:43:28,175
RESOLUTION BY UNDERSTANDING

2643
01:43:28,175 --> 01:43:33,547
TISSUE REPAIR, SLEEP AND STRESS,

2644
01:43:33,547 --> 01:43:35,549
WHOLE PERSON SUPPORT, SOCIETAL

2645
01:43:35,549 --> 01:43:36,850
PRIORITIZATION OF HEALTH

2646
01:43:36,850 --> 01:43:37,351
RESTORATION.

2647
01:43:37,351 --> 01:43:41,421
SO, I'M GOING TO STOP HERE

2648
01:43:41,421 --> 01:43:42,456
UNLESS WE HAVE TIME FOR

2649
01:43:42,456 --> 01:43:44,591
QUESTIONS.

2650
01:43:44,591 --> 01:43:50,630
 

2651
01:43:50,630 --> 01:43:56,069
 

2652
01:43:56,069 --> 01:43:57,838
 

2653
01:43:57,838 --> 01:43:59,139
>> THANKS, HELENE.

2654
01:43:59,139 --> 01:44:00,240
WE'LL OPEN THE FLOOR FOR

2655
01:44:00,240 --> 01:44:01,041
QUESTIONS.

2656
01:44:01,041 --> 01:44:04,411
>> FOR THE LAST PART,
ACUTE TO

2657
01:44:04,411 --> 01:44:05,078
CHRONIC PAIN PREVENTION RESEARCH

2658
01:44:05,078 --> 01:44:07,047
EFFORTS, MY QUESTION WAS RELATED

2659
01:44:07,047 --> 01:44:09,649
TO WHETHER I SAW STUFF ON THE

2660
01:44:09,649 --> 01:44:10,283
PERIPHERAL NERVOUS SYSTEM

2661
01:44:10,283 --> 01:44:13,253
INFLUENCE BUT NOT THE CENTRAL

2662
01:44:13,253 --> 01:44:13,787
NERVOUS SYSTEM INFLUENCE.

2663
01:44:13,787 --> 01:44:17,057
SO MY QUESTION WAS ARE YOU ALSO

2664
01:44:17,057 --> 01:44:20,293
INTEGRATING RESEARCH ON THE ROLE

2665
01:44:20,293 --> 01:44:24,031
OF GENETICS AND CNS DYSFUNCTION

2666
01:44:24,031 --> 01:44:26,233
OR DYSREGULATION TO BETTER

2667
01:44:26,233 --> 01:44:30,804
UNDERSTAND WHO AND WHY CAN

2668
01:44:30,804 --> 01:44:32,039
PREVENT CHRONIC PAIN FROM

2669
01:44:32,039 --> 01:44:33,340
DEVELOPING AND WHO CANNOT.

2670
01:44:33,340 --> 01:44:38,578
>> YES, YOU RECALL I 
LINKED

2671
01:44:38,578 --> 01:44:40,347
THROUGH THE TOP IN BOTH WAYS,

2672
01:44:40,347 --> 01:44:41,281
MAYBE I WENT FAST.

2673
01:44:41,281 --> 01:44:43,383
THERE'S A LINK THROUGH THE

2674
01:44:43,383 --> 01:44:44,251
BOTTOM, PERIPHERAL NERVOUS

2675
01:44:44,251 --> 01:44:49,189
SYSTEM, ALSO THROUGH THE TOP IS

2676
01:44:49,189 --> 01:44:51,258
BECAUSE THE FULL CENTRALLY

2677
01:44:51,258 --> 01:44:53,360
MEDIATED PAIN AND SUFFERING AND

2678
01:44:53,360 --> 01:44:54,227
THAT IMPACTS THE BEHAVIOR,

2679
01:44:54,227 --> 01:44:55,095
RIGHT?

2680
01:44:55,095 --> 01:44:55,862
THAT IMPACTS THE MOVEMENT,

2681
01:44:55,862 --> 01:44:59,032
IMPACTS WHAT THE PERSON DOES.

2682
01:44:59,032 --> 01:45:00,434
AND SO THAT IS HOW IT FEEDS BACK

2683
01:45:00,434 --> 01:45:02,302
TO THE TISSUE THAT WAY.

2684
01:45:02,302 --> 01:45:07,574
IT FEEDS BACK BOTH WAYS.

2685
01:45:07,574 --> 01:45:08,542
IT'S A TWO-WAY CONVERSATION

2686
01:45:08,542 --> 01:45:10,310
BETWEEN THE BRAIN AND CENTRAL

2687
01:45:10,310 --> 01:45:14,014
NERVOUS SYSTEM AND THE

2688
01:45:14,014 --> 01:45:15,015
PERIPHERAL TISSUES.

2689
01:45:15,015 --> 01:45:17,084
KIND OF IT'S A CIRCLE.

2690
01:45:17,084 --> 01:45:21,354
IT'S KIND OF A FEED FORWARD OR

2691
01:45:21,354 --> 01:45:22,189
FEEDBACK CIRCLE.

2692
01:45:22,189 --> 01:45:28,361
DOES THAT ANSWER YOUR QUESTION?

2693
01:45:28,361 --> 01:45:30,664
>> YEAH, THE REASON I
MENTION

2694
01:45:30,664 --> 01:45:32,866
THE LAST FEW SLIDES YOU

2695
01:45:32,866 --> 01:45:35,035
PRESENTED ON ACUTE TO CHRONIC

2696
01:45:35,035 --> 01:45:37,104
AND IF YOU CAN PREVENT THAT,

2697
01:45:37,104 --> 01:45:38,505
LOOKING AT THE PERIPHERAL

2698
01:45:38,505 --> 01:45:39,406
THERAPEUTICS BUT ONE OF THE

2699
01:45:39,406 --> 01:45:40,373
MAJOR QUESTIONS THAT WE HAVE

2700
01:45:40,373 --> 01:45:42,042
ESPECIALLY IN THE WORK THAT WE

2701
01:45:42,042 --> 01:45:45,745
DO ON CHRONIC OVERLAPPING PAIN

2702
01:45:45,745 --> 01:45:50,250
CONDITIONS IS THERE ARE VERY FEW

2703
01:45:50,250 --> 01:45:52,586
LONGITUDINAL STUDIES THAT FOLLOW

2704
01:45:52,586 --> 01:45:53,854
PEOPLE AS THEY DEVELOP MULTIPLE

2705
01:45:53,854 --> 01:45:54,888
CHRONIC PAIN CONDITIONS.

2706
01:45:54,888 --> 01:45:56,823
ONE OF THE REMAINING QUESTIONS

2707
01:45:56,823 --> 01:46:00,794
THAT WE HAVE IS WHETHER THESE

2708
01:46:00,794 --> 01:46:02,095
FOLKS ARE GENETICALLY

2709
01:46:02,095 --> 01:46:03,530
PRE-DISPOSED TO JUST DEVELOPING

2710
01:46:03,530 --> 01:46:04,598
CHRONIC PAIN REGARDLESS OF

2711
01:46:04,598 --> 01:46:07,567
WHETHER THEY HAVE, YOU KNOW, THE

2712
01:46:07,567 --> 01:46:11,938
BEST PHYSICAL THERAPY, 

2713
01:46:11,938 --> 01:46:12,606
ACUPUNCTURE, AND CONVALESCENS

2714
01:46:12,606 --> 01:46:14,908
POSSIBLE OR WHETHER IT CAN BE

2715
01:46:14,908 --> 01:46:16,343
PREVENTED OR REVERSED.

2716
01:46:16,343 --> 01:46:19,179
>> I DIDN'T ANSWER THE
GENETIC.

2717
01:46:19,179 --> 01:46:23,350
GENETICS IS SO IMPORTANT FOR SO

2718
01:46:23,350 --> 01:46:24,651
MANY REASONS.

2719
01:46:24,651 --> 01:46:26,520
FACTORS MIGHT AFFECT SOMEBODY'S

2720
01:46:26,520 --> 01:46:29,256
PAIN PATHWAYS, FOR EXAMPLE, ALSO

2721
01:46:29,256 --> 01:46:31,324
MAY HAVE GENETIC CONDITIONS THAT

2722
01:46:31,324 --> 01:46:32,559
AFFECT THE MUSCULOSKELETAL

2723
01:46:32,559 --> 01:46:36,496
TISSUES THEMSELVES.

2724
01:46:36,496 --> 01:46:42,002
WE'RE ALL FAMILIAR WITH

2725
01:46:42,002 --> 01:46:46,039
EHLERS-DANLOS SYNDROME, PEOPLE

2726
01:46:46,039 --> 01:46:46,940
HAVE CONNECTIVE TISSUES,

2727
01:46:46,940 --> 01:46:47,641
HYPERMOBILE, PREDISPOSING THEM

2728
01:46:47,641 --> 01:46:50,110
TO ALL KINDS OF ISSUES WITH

2729
01:46:50,110 --> 01:46:51,411
RESPECT TO JOINT INSTABILITY AND

2730
01:46:51,411 --> 01:46:56,750
INJURIES, WHICH CAN THEN LEAD TO

2731
01:46:56,750 --> 01:46:57,417
HYPOMOBILITY.

2732
01:46:57,417 --> 01:46:58,285
THERE'S GENETIC, YOU KNOW,

2733
01:46:58,285 --> 01:47:04,324
CONSIDERATION ALL OVER THIS MAP.

2734
01:47:04,324 --> 01:47:08,361
FOR SURE, ABSOLUTELY.

2735
01:47:08,361 --> 01:47:08,662
>> SAMEER?

2736
01:47:08,662 --> 01:47:09,095
>> THANKS, WALTER.

2737
01:47:09,095 --> 01:47:10,664
THAT WAS REALLY INTERESTING.

2738
01:47:10,664 --> 01:47:15,368
I WONDER, I LOVE THE SANDWICH

2739
01:47:15,368 --> 01:47:15,635
METAPHOR.

2740
01:47:15,635 --> 01:47:19,406
I WONDER IF THERE ARE IN

2741
01:47:19,406 --> 01:47:21,041
EXISTENCE TECHNOLOGIES, WEARABLE

2742
01:47:21,041 --> 01:47:26,646
MOBILE TECHNOLOGIES THAT COULD

2743
01:47:26,646 --> 01:47:30,650
CHRONICALLY AND CONTINUOUSLY

2744
01:47:30,650 --> 01:47:31,885
MONITOR DEGREE OF MOBILITY,

2745
01:47:31,885 --> 01:47:32,953
SHEER STRESS, ET CETERA, AS

2746
01:47:32,953 --> 01:47:39,292
WE'RE ALL IN THIS WORLD OF

2747
01:47:39,292 --> 01:47:41,194
WEARABLE MONITORS, WHETHER IT'S

2748
01:47:41,194 --> 01:47:42,696
RECREATIONAL, HOW MANY STEPS YOU

2749
01:47:42,696 --> 01:47:44,331
TAKE OR HEALTH RELATED MORE AND

2750
01:47:44,331 --> 01:47:47,200
MORE AVAILABLE, THAT COULD BE

2751
01:47:47,200 --> 01:47:48,735
OBVIOUSLY USEFUL INFORMATION FOR

2752
01:47:48,735 --> 01:47:52,005
THE INDIVIDUAL, FOR THE CARE

2753
01:47:52,005 --> 01:47:52,239
TEAM.

2754
01:47:52,239 --> 01:47:57,277
YOU KNOW, SOME OF US WORK A LOT

2755
01:47:57,277 --> 01:47:58,578
WITH PACEMAKER-LIKE BRAIN

2756
01:47:58,578 --> 01:47:59,813
STIMULATION DEVICES, DEEP BRAIN

2757
01:47:59,813 --> 01:48:01,214
STIMULATION, ET CETERA, WHICH

2758
01:48:01,214 --> 01:48:02,749
NOW HAVE ABILITY TO REPORT

2759
01:48:02,749 --> 01:48:03,416
NEURAL DATA.

2760
01:48:03,416 --> 01:48:05,819
SO THERE'S A LOT OF INTEREST IN

2761
01:48:05,819 --> 01:48:14,327
PAIRING THE NEURAL RECORDINGS,

2762
01:48:14,327 --> 01:48:16,730
WITH BEHAVIOR IN GENERAL.

2763
01:48:16,730 --> 01:48:18,498
SO INFORMATION FROM A WEARABLE

2764
01:48:18,498 --> 01:48:21,534
THAT TELLS YOU ABOUT

2765
01:48:21,534 --> 01:48:22,969
INFLAMMATION IN THE JOINT OR IN

2766
01:48:22,969 --> 01:48:24,738
A LIMB COULD BE REALLY

2767
01:48:24,738 --> 01:48:28,341
INTERESTING AND USEFUL 

2768
01:48:28,341 --> 01:48:29,976
INFORMATION TO INFORM ININFORM

2769
01:48:29,976 --> 01:48:31,244
THERAPY, WHETHER TO CLINICIAN

2770
01:48:31,244 --> 01:48:32,479
TEAM OR DEVICE.

2771
01:48:32,479 --> 01:48:34,581
>> YES, IT'S COMING.

2772
01:48:34,581 --> 01:48:37,417
SO, ONE OF THE -- A LOT OF

2773
01:48:37,417 --> 01:48:38,285
TECHNIQUES I MENTIONED BEING

2774
01:48:38,285 --> 01:48:41,554
DEVELOPED IN THE CONTEXT OF

2775
01:48:41,554 --> 01:48:43,657
THESE MYOFASCIAL PAIN

2776
01:48:43,657 --> 01:48:44,524
INITIATIVES, TECHNIQUES THAT

2777
01:48:44,524 --> 01:48:47,027
REQUIRE BIG MACHINES AND RIGHT

2778
01:48:47,027 --> 01:48:48,928
NOW THEY ARE STILL AT A BETA

2779
01:48:48,928 --> 01:48:49,129
STAGE.

2780
01:48:49,129 --> 01:48:52,866
ONCE WE KNOW WHAT THE ACTUAL

2781
01:48:52,866 --> 01:48:54,834
MEASUREMENT IS, THEN

2782
01:48:54,834 --> 01:48:55,835
MINIATURIZING AND PUTTING IT IN

2783
01:48:55,835 --> 01:48:58,371
A FORM THAT BECOMES COMPATIBLE

2784
01:48:58,371 --> 01:49:01,074
WITH WEARABLE THAT TECHNOLOGY,

2785
01:49:01,074 --> 01:49:03,310
THAT KIND OF TECHNOLOGY IS

2786
01:49:03,310 --> 01:49:04,210
EXPLODING, RIGHT?

2787
01:49:04,210 --> 01:49:05,712
I HAVE FULL CONFIDENCE ONCE WE

2788
01:49:05,712 --> 01:49:07,747
CAN FIGURE OUT THE RIGHT

2789
01:49:07,747 --> 01:49:11,217
MEASURE, THEN WE CAN MAKE IT

2790
01:49:11,217 --> 01:49:12,986
WEARABLE, IN NOT TOO LONG A

2791
01:49:12,986 --> 01:49:13,553
TIME.

2792
01:49:13,553 --> 01:49:14,954
RIGHT NOW WE'RE NOT -- WE

2793
01:49:14,954 --> 01:49:17,023
UNDERSTAND FOR EXAMPLE HOW TO

2794
01:49:17,023 --> 01:49:18,224
MEASURE SHEER STRAIN, THAT MOVIE

2795
01:49:18,224 --> 01:49:19,125
THAT I TALKED ABOUT, THIS WAS

2796
01:49:19,125 --> 01:49:25,899
DONE IN MY LAB USING NOT FANCY

2797
01:49:25,899 --> 01:49:27,434
ULTRASOUND MACHINE BUT BETTER

2798
01:49:27,434 --> 01:49:29,269
MACHINES CAN DIRECTLY MEASURE

2799
01:49:29,269 --> 01:49:29,469
THAT.

2800
01:49:29,469 --> 01:49:29,836
IT'S COMING.

2801
01:49:29,836 --> 01:49:32,672
NOW, WHAT YOU ALSO MENTIONED WAS

2802
01:49:32,672 --> 01:49:37,043
I THINK VERY INTERESTING, IS

2803
01:49:37,043 --> 01:49:39,012
MEASURING SIMULTANEOUS BRAIN AND

2804
01:49:39,012 --> 01:49:40,113
PERIPHERAL TISSUE MEASUREMENT.

2805
01:49:40,113 --> 01:49:43,383
NOW THAT WILL BE REALLY -- WHEN

2806
01:49:43,383 --> 01:49:45,018
THAT CAN HAPPEN, AND IT'S NOT

2807
01:49:45,018 --> 01:49:49,422
THAT FAR AWAY, IT'S A MATTER OF

2808
01:49:49,422 --> 01:49:50,924
CO-REGISTERING TIME SIGNATURES,

2809
01:49:50,924 --> 01:49:52,792
IT'S NOT DIFFICULT.

2810
01:49:52,792 --> 01:49:56,096
YEAH, I THINK THE AREA OF

2811
01:49:56,096 --> 01:49:57,597
QUANTIFIED SELF IN TERMS OF

2812
01:49:57,597 --> 01:49:59,366
WEARABLE NEEDS TO MOVE IN THE

2813
01:49:59,366 --> 01:50:01,000
DIRECTION OF MORE AND MORE

2814
01:50:01,000 --> 01:50:01,668
LOOKING AT TISSUES.

2815
01:50:01,668 --> 01:50:03,737
ONE AREA THAT I'M PARTICULARLY

2816
01:50:03,737 --> 01:50:07,006
REALLY INTERESTED IN IS TISSUE

2817
01:50:07,006 --> 01:50:07,507
pH.

2818
01:50:07,507 --> 01:50:08,875
IT'S AMAZING HOW MUCH

2819
01:50:08,875 --> 01:50:10,076
INFORMATION THAT CAN GIVE.

2820
01:50:10,076 --> 01:50:12,045
AND BELIEVE IT OR NOT, WE DON'T

2821
01:50:12,045 --> 01:50:15,548
REALLY HAVE A GOOD WAY, WE CAN

2822
01:50:15,548 --> 01:50:19,586
MEASURE YOUR PULSE OXMETRY IN

2823
01:50:19,586 --> 01:50:20,787
FINGERS, WHY NOT THE PH OF THE

2824
01:50:20,787 --> 01:50:24,524
TISSUES, THAT WOULD BE EXTREMELY

2825
01:50:24,524 --> 01:50:29,996
INFORMATIVE. 

2826
01:50:29,996 --> 01:50:31,831
I THINK YOU'RE RIGHT, THIS IS

2827
01:50:31,831 --> 01:50:32,232
WHERE IT'S GOING.

2828
01:50:32,232 --> 01:50:34,401
>> THANK YOU.

2829
01:50:34,401 --> 01:50:40,407
>> THIS IS A BEAUTIFUL AND

2830
01:50:40,407 --> 01:50:43,143
INTERESTING PRESENTATION.

2831
01:50:43,143 --> 01:50:45,912
I'M AT HOME CONVALESCING MYSELF,

2832
01:50:45,912 --> 01:50:47,981
IT HOME QUITE WELL.

2833
01:50:47,981 --> 01:50:51,184
I JUST WANTED TO PIGGYBACK ON

2834
01:50:51,184 --> 01:50:52,252
WHAT SAMEER WAS SAYING.

2835
01:50:52,252 --> 01:50:54,354
WE'RE IN AN AGE WHERE WE CAN

2836
01:50:54,354 --> 01:50:56,189
MEASURE ALL KINDS OF THINGS.

2837
01:50:56,189 --> 01:50:57,390
WE CAN MEASURE SIMULTANEOUSLY

2838
01:50:57,390 --> 01:51:02,195
AND WHAT YOU SAID ABOUT TIME

2839
01:51:02,195 --> 01:51:05,031
STAMPS IS A RELATIVELY SMALL AND

2840
01:51:05,031 --> 01:51:06,566
VERY SOLVABLE PROBLEM.

2841
01:51:06,566 --> 01:51:08,334
YOU MENTIONED SOMETHING LIKE WE

2842
01:51:08,334 --> 01:51:11,938
DON'T KNOW EXACTLY WHAT YET TO

2843
01:51:11,938 --> 01:51:13,606
MEASURE, AND MY SUGGESTION IS WE

2844
01:51:13,606 --> 01:51:14,874
SHOULD MEASURE IT ALL.

2845
01:51:14,874 --> 01:51:17,844
WE SHOULD MEASURE ALL OF IT, AS

2846
01:51:17,844 --> 01:51:19,913
MUCH AS WE CAN, SIMULTANEOUSLY,

2847
01:51:19,913 --> 01:51:21,581
USE THE BIG DEVICES THAT RECORD

2848
01:51:21,581 --> 01:51:23,750
THINGS THAT WE MIGHT NOT EVEN

2849
01:51:23,750 --> 01:51:25,752
THINK HAVE ANYTHING TO DO WITH

2850
01:51:25,752 --> 01:51:27,987
IT BUT WE MIGHT FIND WHEN WE DO

2851
01:51:27,987 --> 01:51:34,828
THE ANALYSIS THAT IT IS QUITE

2852
01:51:34,828 --> 01:51:35,628
IMPORTANT, IMPORTANT ASPECT,

2853
01:51:35,628 --> 01:51:37,030
CO-FACTOR IN RECOVERY.

2854
01:51:37,030 --> 01:51:40,867
I WOULD JUST SUGGEST THAT WE

2855
01:51:40,867 --> 01:51:42,302
RECORD -- START RIGHT AWAY GIVEN

2856
01:51:42,302 --> 01:51:46,673
THIS DAY AND AGE WE'RE IN, ADD

2857
01:51:46,673 --> 01:51:48,875
SUPPLEMENTS TO PEOPLE'S GRANTS

2858
01:51:48,875 --> 01:51:51,177
AND HAVE THEM RECORD AS MUCH

2859
01:51:51,177 --> 01:51:55,682
DATA AS THEY CAN INCLUDING

2860
01:51:55,682 --> 01:51:56,983
HISTORY DATA, EMOTIONAL DATA,

2861
01:51:56,983 --> 01:51:59,486
HEART RATE, SLEEP FOR SURE, AND

2862
01:51:59,486 --> 01:51:59,919
EVERYTHING.

2863
01:51:59,919 --> 01:52:05,992
JUST SEE HOW THAT RELATES TO

2864
01:52:05,992 --> 01:52:06,326
RECOVERY.

2865
01:52:06,326 --> 01:52:08,561
>> I COULDN'T AGREE MORE.

2866
01:52:08,561 --> 01:52:11,331
WE HAD CONVERSATIONS ABOUT

2867
01:52:11,331 --> 01:52:12,065
BUDGETS.

2868
01:52:12,065 --> 01:52:13,600
BUT I THINK YOU'RE TOUCHING ON

2869
01:52:13,600 --> 01:52:14,801
AN IMPORTANT POINT.

2870
01:52:14,801 --> 01:52:16,369
ONE SIDE I'D LIKE TO SHOW,

2871
01:52:16,369 --> 01:52:18,438
RECOVERY DOESN'T GO IN A

2872
01:52:18,438 --> 01:52:19,005
STRAIGHT LINE.

2873
01:52:19,005 --> 01:52:20,640
TYPICALLY, PEOPLE HAVE GOOD DAYS

2874
01:52:20,640 --> 01:52:21,608
AND BAD DAYS, RIGHT?

2875
01:52:21,608 --> 01:52:25,211
IF YOU HAVE MORE GOOD DAYS THAN

2876
01:52:25,211 --> 01:52:27,614
BAD DAYS OVERALL TRAJECTORY GOES

2877
01:52:27,614 --> 01:52:28,515
TOWARDS RECOVERY.

2878
01:52:28,515 --> 01:52:30,683
IF YOU HAVE MORE BAD THAN GOOD

2879
01:52:30,683 --> 01:52:35,288
DAYS YOU STAY SICK OR WHATEVER.

2880
01:52:35,288 --> 01:52:36,456
HOW TO HELP PATIENTS BECOME

2881
01:52:36,456 --> 01:52:37,891
AWARE OF WHAT'S GOING ON IN

2882
01:52:37,891 --> 01:52:38,691
THEIR BODIES WHEN THEY ARE

2883
01:52:38,691 --> 01:52:40,460
HAVING A GOOD DAY VERSUS NOT

2884
01:52:40,460 --> 01:52:43,263
HAVING A GOOD DAY, HOW TO TURN A

2885
01:52:43,263 --> 01:52:45,698
GOOD DAY INTO -- A BAD DAY INTO

2886
01:52:45,698 --> 01:52:48,101
A GOOD DAY OR, YOU KNOW -- A LOT

2887
01:52:48,101 --> 01:52:52,906
OF THAT IS JUST -- COULD BE

2888
01:52:52,906 --> 01:52:54,574
GAINED THROUGH JOURNALING AND AS

2889
01:52:54,574 --> 01:52:56,409
WELL AS MEASURING WHAT'S GOING

2890
01:52:56,409 --> 01:52:58,611
ON IN YOUR -- THE AUTONOMIC

2891
01:52:58,611 --> 01:53:00,813
NERVOUS SYSTEM WILL BE EXTREMELY

2892
01:53:00,813 --> 01:53:01,447
IMPORTANT HERE, UNDERSTANDING

2893
01:53:01,447 --> 01:53:02,882
HOW YOUR BODY IS RECOVERING

2894
01:53:02,882 --> 01:53:05,051
BECAUSE WE ALL KNOW RECOVERING

2895
01:53:05,051 --> 01:53:07,020
FROM ANYTHING WHERE THERE'S AN

2896
01:53:07,020 --> 01:53:08,555
INJURY OR ILLNESS INVOLVES ALL

2897
01:53:08,555 --> 01:53:10,323
YOUR SYSTEMS OF OUR BODY WHEN

2898
01:53:10,323 --> 01:53:12,058
YOU'RE INACTIVE BECAUSE YOU'VE

2899
01:53:12,058 --> 01:53:15,762
BEEN SICK, YOU KNOW, MUSCLE

2900
01:53:15,762 --> 01:53:17,964
STRENGTH, STAMINA, APPETITE IS

2901
01:53:17,964 --> 01:53:18,331
OFF.

2902
01:53:18,331 --> 01:53:20,133
YOUR SLEEP IS OFF.

2903
01:53:20,133 --> 01:53:20,633
TEMPERATURE REGULATION.

2904
01:53:20,633 --> 01:53:23,570
THERE'S ALL KINDS OF SYSTEMS

2905
01:53:23,570 --> 01:53:25,305
THAT NEED TO NOW REGAIN THEIR

2906
01:53:25,305 --> 01:53:25,638
FUNCTION.

2907
01:53:25,638 --> 01:53:27,073
SO OF COURSE THAT'S NOT GOING TO

2908
01:53:27,073 --> 01:53:28,908
GO IN A STRAIGHT LINE.

2909
01:53:28,908 --> 01:53:32,345
GETTING DATA ON THAT AND HELPING

2910
01:53:32,345 --> 01:53:33,646
PEOPLE TO UNDERSTAND WHAT'S

2911
01:53:33,646 --> 01:53:35,615
GOING ON AND PROBABLY GOING TO

2912
01:53:35,615 --> 01:53:37,584
BE HIGHLY INDIVIDUAL.

2913
01:53:37,584 --> 01:53:39,652
IT'S NOT TWO PEOPLE RECOVER THE

2914
01:53:39,652 --> 01:53:40,987
SAME WAY.

2915
01:53:40,987 --> 01:53:42,855
IT DEPENDS ON THEIR PHYSIOLOGY,

2916
01:53:42,855 --> 01:53:43,189
RIGHT?

2917
01:53:43,189 --> 01:53:45,024
SO, THIS IS AN AREA WHERE I

2918
01:53:45,024 --> 01:53:46,659
THINK WE CAN MAKE SO MUCH

2919
01:53:46,659 --> 01:53:48,094
PROGRESS THAT WOULD HELP PEOPLE

2920
01:53:48,094 --> 01:53:52,899
TO NOT ONLY RECOVER BUT ALSO

2921
01:53:52,899 --> 01:53:54,701
PREVENT LONG-TERM PROBLEMS.

2922
01:53:54,701 --> 01:53:58,037
SO I AGREE.

2923
01:53:58,037 --> 01:53:58,471
>> AMEN, SISTER.

2924
01:53:58,471 --> 01:53:59,005
THANK YOU.

2925
01:53:59,005 --> 01:54:01,207
>> CAN YOU SEE THE CHAT.

2926
01:54:01,207 --> 01:54:04,043
DR. POE IS INTERESTED IN SLEEP

2927
01:54:04,043 --> 01:54:05,011
AND INTERACTION WITH PAIN.

2928
01:54:05,011 --> 01:54:05,378
>> ALL RIGHT.

2929
01:54:05,378 --> 01:54:06,913
>> I DON'T KNOW IF YOU
HAVE

2930
01:54:06,913 --> 01:54:09,515
COMMENTS THERE.

2931
01:54:09,515 --> 01:54:14,020
 

2932
01:54:14,020 --> 01:54:19,892
LET ME ASK YOU, I KNOW YOU HAVE

2933
01:54:19,892 --> 01:54:25,365
INTEREST IN PAIN RESOLUTION 

2934
01:54:25,365 --> 01:54:25,832
THROUGH DIFFERENT

2935
01:54:25,832 --> 01:54:26,466
MUSCULOSKELETAL MANIPULATIONS,

2936
01:54:26,466 --> 01:54:28,101
ANYTHING YOU COULD TALK TO US

2937
01:54:28,101 --> 01:54:31,304
ABOUT, HOW YOU THINK THAT'S

2938
01:54:31,304 --> 01:54:31,704
WORKING?

2939
01:54:31,704 --> 01:54:31,971
>> YEAH.

2940
01:54:31,971 --> 01:54:33,573
YOU KNOW, I HAD A BUNCH OF OVER

2941
01:54:33,573 --> 01:54:35,775
SLIDES I DIDN'T HAVE TIME TO

2942
01:54:35,775 --> 01:54:36,309
SHOW YOU.

2943
01:54:36,309 --> 01:54:37,310
BUT THERE'S SOME REALLY

2944
01:54:37,310 --> 01:54:38,177
INTERESTING RESEARCH GOING ON

2945
01:54:38,177 --> 01:54:39,045
RIGHT NOW.

2946
01:54:39,045 --> 01:54:42,248
WE'VE KNOWN FOR A WHILE THAT NOT

2947
01:54:42,248 --> 01:54:43,449
ALL MECHANICAL FORCES ACT THE

2948
01:54:43,449 --> 01:54:44,083
SAME WAY.

2949
01:54:44,083 --> 01:54:46,185
BACK IN THE '90s THERE WERE

2950
01:54:46,185 --> 01:54:47,720
SOME STUDIES ON CULTURED CELLS

2951
01:54:47,720 --> 01:54:51,324
THAT LOOKED AT THE EFFECTS OF

2952
01:54:51,324 --> 01:54:52,759
SMALL AMPLITUDE FORCE VERSUS

2953
01:54:52,759 --> 01:54:53,760
LARGER AMPLITUDE FORCE.

2954
01:54:53,760 --> 01:54:58,031
YOU CAN SEE THE DIFFERENCE IN

2955
01:54:58,031 --> 01:54:58,998
INFLAMMATORY CYTOKINES WHEN THE

2956
01:54:58,998 --> 01:55:02,702
FORCE IS LARGE.

2957
01:55:02,702 --> 01:55:04,037
ACTUALLY, THE ANTI-INFLAMMATORY

2958
01:55:04,037 --> 01:55:06,105
CYTOKINES WHEN THE FORCE IS

2959
01:55:06,105 --> 01:55:06,673
SMALL.

2960
01:55:06,673 --> 01:55:10,910
IT'S NOT THAT THE SMALL FORCE IS

2961
01:55:10,910 --> 01:55:12,345
INJURIOUS, IT'S BENEFICIAL.

2962
01:55:12,345 --> 01:55:14,547
THERE'S BEEN A VARIETY OF

2963
01:55:14,547 --> 01:55:15,214
RESEARCH, MORE RECENT AT HARVARD

2964
01:55:15,214 --> 01:55:18,685
MEDICAL SCHOOL IN A LAB THAT

2965
01:55:18,685 --> 01:55:20,987
DOES COMPRESSION USING PNEUMATIC

2966
01:55:20,987 --> 01:55:22,622
DEVICE, VERY WELL CONTROLLED,

2967
01:55:22,622 --> 01:55:23,856
VERY SMALL AMOUNT OF FORCE

2968
01:55:23,856 --> 01:55:25,391
EXERTED ON A MUSCLE AFTER IT'S

2969
01:55:25,391 --> 01:55:26,959
BEEN INJURED AND COMPRESS FOR

2970
01:55:26,959 --> 01:55:28,227
FIVE MINUTES TWICE A DAY, THAT'S

2971
01:55:28,227 --> 01:55:29,429
NOT A LOT.

2972
01:55:29,429 --> 01:55:30,496
THE AMOUNT OF COMPRESSION THEY

2973
01:55:30,496 --> 01:55:34,000
DO IS OF THE ORDER OF 20% STRAIN

2974
01:55:34,000 --> 01:55:35,668
WHICH IS VERY SMALL, RIGHT?

2975
01:55:35,668 --> 01:55:39,706
YOU KNOW, IT'S NOT A BIG

2976
01:55:39,706 --> 01:55:40,139
SQUEEZE.

2977
01:55:40,139 --> 01:55:42,675
BUT THEY SHOW THAT INFLAMMATION

2978
01:55:42,675 --> 01:55:44,544
IS DOWN, MUSCLE STRENGTH IS

2979
01:55:44,544 --> 01:55:45,845
RECOVERED FASTER, AND THE OTHER

2980
01:55:45,845 --> 01:55:47,914
INTERESTING THING THEY SHOW IS

2981
01:55:47,914 --> 01:55:50,416
THAT THEY DO -- INJECT SOME HIGH

2982
01:55:50,416 --> 01:55:52,652
MOLECULAR WEIGHT DEXTRAN IN THE

2983
01:55:52,652 --> 01:55:54,587
ISSUES, YOU SEE THAT THE DEXTRAN

2984
01:55:54,587 --> 01:55:57,990
IS CLEARED FASTER IN RESPONSE TO

2985
01:55:57,990 --> 01:55:59,959
THE MECHANICAL FORCE, WHICH

2986
01:55:59,959 --> 01:56:03,262
SUGGESTS THAT FORCE IS HELPING

2987
01:56:03,262 --> 01:56:05,098
TISSUE GET RID OF DEBRIS AND

2988
01:56:05,098 --> 01:56:09,035
KIND OF THE -- YOU KNOW, EFFECTS

2989
01:56:09,035 --> 01:56:12,004
OF THE INJURY.

2990
01:56:12,004 --> 01:56:15,141
AGAIN, THAT INTERACTION BETWEEN

2991
01:56:15,141 --> 01:56:16,576
METABOLIC, STRUCTURE, AND THE

2992
01:56:16,576 --> 01:56:16,909
MECHANICS.

2993
01:56:16,909 --> 01:56:18,444
I THINK ALL OF THAT NOW IS

2994
01:56:18,444 --> 01:56:20,980
REALLY COMING INTO ITS OWN.

2995
01:56:20,980 --> 01:56:25,251
THE WHOLE FIELD OF

2996
01:56:25,251 --> 01:56:27,687
MECHANOTHERAPEUTICS IS

2997
01:56:27,687 --> 01:56:27,987
DEVELOPING.

2998
01:56:27,987 --> 01:56:28,855
IT'S FAR BEHIND PHARMACO

2999
01:56:28,855 --> 01:56:29,288
THERAPEUTICS.

3000
01:56:29,288 --> 01:56:31,858
IT HAS A LONG WAY TO GO BUT I

3001
01:56:31,858 --> 01:56:40,032
THINK IT HAS A LOT OF PROMISE. 

3002
01:56:40,032 --> 01:56:40,933
>> THANKS SO MUCH.

3003
01:56:40,933 --> 01:56:42,068
WE REALLY APPRECIATE IT.

3004
01:56:42,068 --> 01:56:43,002
>> THANK YOU.

3005
01:56:43,002 --> 01:56:45,271
THANK YOU FOR THE INVITATION.

3006
01:56:45,271 --> 01:56:47,240
>> OH, A PLEASURE.

3007
01:56:47,240 --> 01:56:49,942
NOW WE'RE GOING INTO AN UPDATE

3008
01:56:49,942 --> 01:56:51,944
ON THE HEAL INITIATIVE.

3009
01:56:51,944 --> 01:56:55,214
I WANT TO MENTION BEFORE DAVE

3010
01:56:55,214 --> 01:56:57,116
DOES THAT INTRO THAT CHRIS

3011
01:56:57,116 --> 01:56:59,719
VEASLEY IS HERE, AND SHE IS --

3012
01:56:59,719 --> 01:57:03,422
SHE WAS AT THE LAST "HEAL"

3013
01:57:03,422 --> 01:57:04,190
MULTI-DISCIPLINARY WORKING GROUP

3014
01:57:04,190 --> 01:57:05,191
MEETING AND CAN BE A LINK

3015
01:57:05,191 --> 01:57:07,927
BETWEEN THAT GROUP WHICH LOOKS

3016
01:57:07,927 --> 01:57:09,796
AT "HEAL" FUNDING PROGRAMS AND

3017
01:57:09,796 --> 01:57:11,998
INITIATIVES BEFORE THEY COME TO

3018
01:57:11,998 --> 01:57:12,231
COUNCIL.

3019
01:57:12,231 --> 01:57:13,499
SO DAVE?

3020
01:57:13,499 --> 01:57:13,966
>> OKAY.

3021
01:57:13,966 --> 01:57:17,003
THANKS, WALTER.

3022
01:57:17,003 --> 01:57:17,770
>> THANKS, CHRIS.

3023
01:57:17,770 --> 01:57:18,971
>> SO ONCE A YEAR WE GET
AN

3024
01:57:18,971 --> 01:57:20,540
UPDATE FROM THE HEAL INITIATIVE

3025
01:57:20,540 --> 01:57:20,773
PROGRAM.

3026
01:57:20,773 --> 01:57:23,609
THIS YEAR WE'RE HAVING IT FROM

3027
01:57:23,609 --> 01:57:26,112
MICHAEL OSHINSKY IN OUR DIVISION

3028
01:57:26,112 --> 01:57:26,979
OF NEUROSCIENCE AND LINDA

3029
01:57:26,979 --> 01:57:28,614
PORTER, CHIEF OF PAIN POLICY.

3030
01:57:28,614 --> 01:57:31,384
MY UNDERSTANDING IS MICHAEL, YOU

3031
01:57:31,384 --> 01:57:32,785
WILL BE GOING FIRST.

3032
01:57:32,785 --> 01:57:33,886
IT'S ALL YOURS.

3033
01:57:33,886 --> 01:57:36,622
>> THANK YOU SO MUCH,
DAVE.

3034
01:57:36,622 --> 01:57:40,359
I'LL WAIT FOR THE SLIDES.

3035
01:57:40,359 --> 01:57:43,763
I'M EXCITED TO SPEAK ABOUT SOME

3036
01:57:43,763 --> 01:57:46,465
ACCOMPLISHMENTS, SOME GOAL POSTS

3037
01:57:46,465 --> 01:57:48,668
THAT WE'VE PASSED IN THE HEAL

3038
01:57:48,668 --> 01:57:49,468
INITIATIVE SINCE WE STARTED

3039
01:57:49,468 --> 01:57:51,537
ABOUT FIVE YEARS AGO.

3040
01:57:51,537 --> 01:57:56,242
WE HAVE THESE PROGRAMS THAT ARE

3041
01:57:56,242 --> 01:57:57,677
IN THE CASE, PRESENTATION I'LL

3042
01:57:57,677 --> 01:58:00,313
BE GIVING, RELATED TO

3043
01:58:00,313 --> 01:58:01,814
PRE-CLINICAL AND TRANSLATIONAL

3044
01:58:01,814 --> 01:58:03,249
RESEARCH IN PAIN, INSIDE THE

3045
01:58:03,249 --> 01:58:04,016
HEAL INITIATIVE.

3046
01:58:04,016 --> 01:58:07,420
THE LAST TIME WE GAVE YOU THE

3047
01:58:07,420 --> 01:58:09,622
UPDATE WAS DURING THE SUMMER.

3048
01:58:09,622 --> 01:58:14,527
SO THESE ARE ACCOMPLISHMENTS 

3049
01:58:14,527 --> 01:58:15,027
SINCE THAT TIME.

3050
01:58:15,027 --> 01:58:18,898
AND -- NEXT SLIDE PLEASE.

3051
01:58:18,898 --> 01:58:21,300
 

3052
01:58:21,300 --> 01:58:23,603
FIRST THING I WANT TO SPEAK TO

3053
01:58:23,603 --> 01:58:25,671
YOU ABOUT IS WHAT'S THE FOCUS OF

3054
01:58:25,671 --> 01:58:28,975
THESE PROGRAMS. 

3055
01:58:28,975 --> 01:58:31,010
WHAT'S THE FOCUS OF THE PAIN

3056
01:58:31,010 --> 01:58:33,446
PORTION OF THE HEAL INITIATIVE,

3057
01:58:33,446 --> 01:58:36,082
AND THE GUIDING LIGHT, IF YOU

3058
01:58:36,082 --> 01:58:37,617
WILL, FOR THE INITIATIVES THAT

3059
01:58:37,617 --> 01:58:41,120
WE HAVE INSIDE OF "HEAL" FOR

3060
01:58:41,120 --> 01:58:42,989
ENHANCING PAIN MANAGEMENT.

3061
01:58:42,989 --> 01:58:44,624
NOW, THE TOP TWO ARE THE ONES

3062
01:58:44,624 --> 01:58:47,260
I'LL BE FOCUSING ON IN MY

3063
01:58:47,260 --> 01:58:48,127
PRESENTATION.

3064
01:58:48,127 --> 01:58:50,196
THAT'S UNDERSTANDING THE

3065
01:58:50,196 --> 01:58:52,064
BIOLOGICAL UNDERPINNINGS OF

3066
01:58:52,064 --> 01:58:54,567
CHRONIC PAIN AND REALLY

3067
01:58:54,567 --> 01:58:55,568
IDENTIFYING MOLECULES THAT

3068
01:58:55,568 --> 01:58:58,104
TARGET AND CELL TYPES AND NERVES

3069
01:58:58,104 --> 01:59:00,273
THAT COULD BE USED POTENTIALLY

3070
01:59:00,273 --> 01:59:03,876
TO FIRST OF ALL INCREASE OUR

3071
01:59:03,876 --> 01:59:06,979
UNDERSTANDING OF PAIN AND THEN

3072
01:59:06,979 --> 01:59:08,814
ACT AS TARGETS FOR TREATMENT.

3073
01:59:08,814 --> 01:59:11,784
AND THEN OF COURSE TO ACCELERATE

3074
01:59:11,784 --> 01:59:13,653
DISCOVERY IN PRE-CLINICAL

3075
01:59:13,653 --> 01:59:14,854
DEVELOPMENT OF THOSE

3076
01:59:14,854 --> 01:59:17,723
NON-ADDICTIVE PAIN TREATMENTS.

3077
01:59:17,723 --> 01:59:20,226
TREATMENTS THAT HAVE LOW

3078
01:59:20,226 --> 01:59:23,596
LIABILITY FOR BEING REINFORCING

3079
01:59:23,596 --> 01:59:27,667
AND THEN LEAD TO OVERDOSE.

3080
01:59:27,667 --> 01:59:28,768
THAT'S A CENTRAL THEME IN THE

3081
01:59:28,768 --> 01:59:29,635
HEAL INITIATIVE.

3082
01:59:29,635 --> 01:59:34,774
AT THIS POINT "HEAL" INVESTED

3083
01:59:34,774 --> 01:59:36,208
$1.25 BILLION ON PAIN RESEARCH

3084
01:59:36,208 --> 01:59:39,512
AND CROSS-CUTTING RESEARCH.

3085
01:59:39,512 --> 01:59:40,546
THAT'S CROSS-CUTTING RESEARCH

3086
01:59:40,546 --> 01:59:42,581
INCLUDES RESEARCH ON OPIOID USE

3087
01:59:42,581 --> 01:59:43,449
DISORDER, SUBSTANCE USE

3088
01:59:43,449 --> 01:59:46,619
DISORDER, AS WELL AS PAIN.

3089
01:59:46,619 --> 01:59:50,022
LET'S SAY LOOKING AT PAIN IN

3090
01:59:50,022 --> 01:59:51,991
INDIVIDUALS THAT HAVE CHRONIC

3091
01:59:51,991 --> 02:00:00,633
OPIOID EXPOSURE, ET CETERA. 

3092
02:00:00,633 --> 02:00:01,534
NEXT SLIDE.

3093
02:00:01,534 --> 02:00:08,841
SO, THIS GOAL THAT "HEAL" HAS TO

3094
02:00:08,841 --> 02:00:09,942
DEVELOP EFFECTIVE NON-ADDICTIVE

3095
02:00:09,942 --> 02:00:11,377
PAIN TREATMENTS WE HAVE TO HAVE

3096
02:00:11,377 --> 02:00:13,879
A METHOD OR PATHWAY TO

3097
02:00:13,879 --> 02:00:15,114
SUPPORTING THE FIELD FOR

3098
02:00:15,114 --> 02:00:16,082
DEVELOPING THAT.

3099
02:00:16,082 --> 02:00:17,249
NOW, WE KNOW AT THE END OF THE

3100
02:00:17,249 --> 02:00:20,920
LINE IT'S GOING TO BE A COMPANY

3101
02:00:20,920 --> 02:00:23,222
OR SOME COMMERCIAL ENTITY.

3102
02:00:23,222 --> 02:00:26,058
BUT IN ORDER TO GET THOSE

3103
02:00:26,058 --> 02:00:30,529
COMMERCIAL ENTITIES, IN ORDER TO

3104
02:00:30,529 --> 02:00:34,367
GET PHARMA INVOLVED HERE, WE

3105
02:00:34,367 --> 02:00:36,902
HAVE TO DE-RISK PRE-CLINICAL,

3106
02:00:36,902 --> 02:00:40,940
DE-RISK PARTS THAT WOULD LEAD TO

3107
02:00:40,940 --> 02:00:42,908
THE ASSETS THAT ARE READY FOR

3108
02:00:42,908 --> 02:00:46,312
CLINICAL TRIALS THAT CAN BE

3109
02:00:46,312 --> 02:00:52,218
TESTED AND THEN ADOPT A PARTNER

3110
02:00:52,218 --> 02:00:54,286
THAT CAN PERFORM THE PIVOTAL

3111
02:00:54,286 --> 02:00:55,821
STUDIES AND BRING THOSE THINGS

3112
02:00:55,821 --> 02:00:56,455
TO MARKET.

3113
02:00:56,455 --> 02:00:58,324
SO, THAT'S WHY THE FOCUS OF OUR

3114
02:00:58,324 --> 02:01:00,726
PROGRAMS ARE ON THIS VALIDATION

3115
02:01:00,726 --> 02:01:02,928
OF THESE BIOLOGICAL TARGETS,

3116
02:01:02,928 --> 02:01:03,729
IDENTIFYING BIOMARKERS IN THE

3117
02:01:03,729 --> 02:01:06,198
HUMAN CONDITION THAT CAN BE USED

3118
02:01:06,198 --> 02:01:08,534
FOR THOSE CLINICAL TRIALS AND

3119
02:01:08,534 --> 02:01:11,570
SEEDING THE INITIAL DEVELOPMENT

3120
02:01:11,570 --> 02:01:12,972
OF THOSE NOVEL TREATMENTS EVEN

3121
02:01:12,972 --> 02:01:17,243
AT EARLY STAGES OR EVEN AT THOSE

3122
02:01:17,243 --> 02:01:20,312
OPTIMIZATION STAGES.

3123
02:01:20,312 --> 02:01:20,980
NEXT SLIDE.

3124
02:01:20,980 --> 02:01:26,218
AND THAT'S WHAT YOU CAN SEE IN

3125
02:01:26,218 --> 02:01:27,420
THIS SLIDE.

3126
02:01:27,420 --> 02:01:30,156
WE'RE GOING TO SEE THERE'S 14 --

3127
02:01:30,156 --> 02:01:33,893
SO ON THE LEFT SIDE, AT THE TOP

3128
02:01:33,893 --> 02:01:36,529
YOU SEE THE CHEVRON DIAGRAM WE

3129
02:01:36,529 --> 02:01:37,930
SHOWED SEVERAL TIMES.

3130
02:01:37,930 --> 02:01:40,666
YOU SEE STAGES OF DEVELOPMENT OF

3131
02:01:40,666 --> 02:01:42,301
THERAPEUTICS FROM DISCOVERY,

3132
02:01:42,301 --> 02:01:43,302
PRE-CLINICAL DEVELOPMENT,

3133
02:01:43,302 --> 02:01:44,603
CLINICAL TRIALS, IMPLEMENTATION

3134
02:01:44,603 --> 02:01:45,538
AND DISSEMINATION.

3135
02:01:45,538 --> 02:01:47,773
SO ON THE LEFT SIDE ARE THE

3136
02:01:47,773 --> 02:01:51,110
PROGRAMS THAT ARE IN THE

3137
02:01:51,110 --> 02:01:53,112
PRE-CLINICAL AND TRANSLATIONAL

3138
02:01:53,112 --> 02:01:55,047
PORTION OF THE HEAL INITIATIVE

3139
02:01:55,047 --> 02:01:56,615
PAIN RESEARCH PORTFOLIO, AND

3140
02:01:56,615 --> 02:01:58,984
THERE'S 14 DIFFERENT PROGRAMS

3141
02:01:58,984 --> 02:02:00,486
CURRENTLY ONGOING OTHER THAT HAD

3142
02:02:00,486 --> 02:02:03,456
RECENT RECEIPT DATES OR FUTURE

3143
02:02:03,456 --> 02:02:06,092
RECEIPT DATES, AND THE ONES IN

3144
02:02:06,092 --> 02:02:08,727
GRAY ARE THE MORE CLINICALLY

3145
02:02:08,727 --> 02:02:11,130
RELATED ONES, OR THE ONES THAT

3146
02:02:11,130 --> 02:02:14,066
WILL BE IN LINDA PORTER'S

3147
02:02:14,066 --> 02:02:16,836
PRESENTATION AFTER MINE.

3148
02:02:16,836 --> 02:02:19,238
I'M GOING TO PICK A FEW THAT HAD

3149
02:02:19,238 --> 02:02:22,074
SIGNIFICANT ACCOMPLISHMENTS THIS

3150
02:02:22,074 --> 02:02:23,275
YEAR AND THAT'S WHAT I'M GOING

3151
02:02:23,275 --> 02:02:24,410
TO PRESENT.

3152
02:02:24,410 --> 02:02:28,747
NEXT SLIDE.

3153
02:02:28,747 --> 02:02:30,182
SO, DE-RISKING OF PRE-CLINICAL

3154
02:02:30,182 --> 02:02:31,150
AND EARLY CLINICAL DEVELOPMENT

3155
02:02:31,150 --> 02:02:34,453
IS REALLY WHAT OUR GOAL IS.

3156
02:02:34,453 --> 02:02:35,855
THE REASON WE'RE FOCUSING ON

3157
02:02:35,855 --> 02:02:37,923
THAT IS BECAUSE THERE WAS

3158
02:02:37,923 --> 02:02:41,127
SEVERAL PAPERS THAT CAME OUT

3159
02:02:41,127 --> 02:02:47,800
SHOWING THAT NOT JUST A

3160
02:02:47,800 --> 02:02:50,402
FINANCIAL INVOLVEMENT WAS BEING

3161
02:02:50,402 --> 02:02:55,541
REMOVED FROM THIS AREA FROM

3162
02:02:55,541 --> 02:02:56,876
PHARMA BUT ALSO THIS INCENTIVE

3163
02:02:56,876 --> 02:02:57,843
FOR DOING THE WORK.

3164
02:02:57,843 --> 02:03:01,013
I MEAN, IS IT GOING TO BE

3165
02:03:01,013 --> 02:03:01,647
SUCCESSFUL?

3166
02:03:01,647 --> 02:03:03,549
WAS LEADING TO MANY, MANY

3167
02:03:03,549 --> 02:03:05,518
COMPANIES AND MANY RESEARCHERS

3168
02:03:05,518 --> 02:03:06,585
COMING OUT OF THIS PARTICULAR

3169
02:03:06,585 --> 02:03:07,353
AREA.

3170
02:03:07,353 --> 02:03:11,524
SO THERE WAS A PAPER PUBLISHED

3171
02:03:11,524 --> 02:03:16,662
IN 2022, BY MAURER  ET AL.

3172
02:03:16,662 --> 02:03:18,531
LOOKING AT CLINICAL DEVELOPMENT

3173
02:03:18,531 --> 02:03:21,133
PROGRAM, THEY HAD FINISHED,

3174
02:03:21,133 --> 02:03:22,334
GREAT LEADS, TOXICITY TESTING,

3175
02:03:22,334 --> 02:03:23,269
IT WAS FINE, NOW THEY WERE GOING

3176
02:03:23,269 --> 02:03:25,171
TO DO CLINICAL TRIALS.

3177
02:03:25,171 --> 02:03:27,573
JUST LOOKING AT CLINICAL TRIALS,

3178
02:03:27,573 --> 02:03:31,877
IN clinicaltrials.gov,

3179
02:03:31,877 --> 02:03:32,945
ANALGESIC DEVELOPMENT, A HUGE

3180
02:03:32,945 --> 02:03:34,146
DIFFERENCE BETWEEN SUCCESS OF

3181
02:03:34,146 --> 02:03:35,381
THOSE WITH LOW ABUSE POTENTIAL

3182
02:03:35,381 --> 02:03:37,883
AND THOSE WITH A HIGH ABUSE

3183
02:03:37,883 --> 02:03:39,618
POTENTIAL.

3184
02:03:39,618 --> 02:03:42,254
THOSE WITH HIGH ABUSE POTENTIAL,

3185
02:03:42,254 --> 02:03:44,456
IN MANY CASES OPIOIDS HERE,

3186
02:03:44,456 --> 02:03:46,292
THERE'S BASICALLY ONE IN THREE

3187
02:03:46,292 --> 02:03:49,061
OF THOSE PROGRAMS WERE

3188
02:03:49,061 --> 02:03:49,361
SUCCESSFUL.

3189
02:03:49,361 --> 02:03:51,997
THAT'S LIKE 30%.

3190
02:03:51,997 --> 02:03:53,199
ABSOLUTELY A GOOD BET, SAY IT

3191
02:03:53,199 --> 02:03:54,300
THAT WAY.

3192
02:03:54,300 --> 02:03:56,702
BUT FOR THOSE WITH LOW ABUSE

3193
02:03:56,702 --> 02:03:59,772
POTENTIAL LESS THAN 5%.

3194
02:03:59,772 --> 02:04:03,709
SO YOU HAD THIS FIVE TO SIX-FOLD

3195
02:04:03,709 --> 02:04:06,545
DIFFERENCE IN RISK, IF THEY WERE

3196
02:04:06,545 --> 02:04:07,980
LOW ABUSE POTENTIAL ANALGESICS

3197
02:04:07,980 --> 02:04:10,716
THAT WERE GOING INTO CLINICAL

3198
02:04:10,716 --> 02:04:11,016
DEVELOPMENT.

3199
02:04:11,016 --> 02:04:12,885
AND THAT'S WHY THE HEAL

3200
02:04:12,885 --> 02:04:14,987
INITIATIVE IS TRYING TO

3201
02:04:14,987 --> 02:04:15,988
FACILITATE AND DE-RISK THAT

3202
02:04:15,988 --> 02:04:18,023
EARLY DEVELOPMENT SO BECAUSE OF

3203
02:04:18,023 --> 02:04:22,194
THAT THEY PULLED OUT OF ALL THE

3204
02:04:22,194 --> 02:04:23,295
INVESTMENTS, VAST MAJORITY OF

3205
02:04:23,295 --> 02:04:26,265
INVESTMENTS THEY WERE DOING IN

3206
02:04:26,265 --> 02:04:28,100
DEVELOPING ANALGESICS WITH LOW

3207
02:04:28,100 --> 02:04:30,202
ABUSE POTENTIAL, WAY TOO RISKY.

3208
02:04:30,202 --> 02:04:32,705
AND THAT'S WHY "HEAL" IS FOCUSED

3209
02:04:32,705 --> 02:04:34,240
THERE, DE-RISK THESE PROJECTS SO

3210
02:04:34,240 --> 02:04:37,076
WE CAN GET PARTNERS LATER, IN

3211
02:04:37,076 --> 02:04:41,046
ORDER TO DEVELOP -- FINISH

3212
02:04:41,046 --> 02:04:41,547
DEVELOPING THERAPEUTICS.

3213
02:04:41,547 --> 02:04:46,385
WE HAVE MORE THAN 50 TARGETS IN 

3214
02:04:46,385 --> 02:04:48,454
THE PROGRAM, VALIDATION STAGE,

3215
02:04:48,454 --> 02:04:50,956
SEVERAL GRADUATED INTO THE LATER

3216
02:04:50,956 --> 02:04:51,957
STAGE PROGRAMS.

3217
02:04:51,957 --> 02:04:56,128
AND MANY OF THE PROGRAMS, IF NOT

3218
02:04:56,128 --> 02:04:57,896
ALL OF THESE, ENCOURAGE OR

3219
02:04:57,896 --> 02:04:59,131
REQUIRE THAT ABUSE LIABILITY

3220
02:04:59,131 --> 02:05:01,934
TESTING EARLY ON SO WE CAN

3221
02:05:01,934 --> 02:05:04,670
ELIMINATE TARGETS THAT MAY HAVE

3222
02:05:04,670 --> 02:05:08,240
THAT POTENTIAL.

3223
02:05:08,240 --> 02:05:10,376
NEXT SLIDE.

3224
02:05:10,376 --> 02:05:11,577
ALL RIGHT.

3225
02:05:11,577 --> 02:05:15,080
SO LET'S TALK ABOUT THE

3226
02:05:15,080 --> 02:05:19,118
PRECISION HUMAN PAIN NETWORK.

3227
02:05:19,118 --> 02:05:21,954
SO, THE VALIDATION OF THESE

3228
02:05:21,954 --> 02:05:24,790
TARGETS, ONE THING WE HEARD LOUD

3229
02:05:24,790 --> 02:05:28,327
AND CLEAR WAS THAT THE 

3230
02:05:28,327 --> 02:05:30,729
DE-RISKING IS GOING TO NEED

3231
02:05:30,729 --> 02:05:33,565
HUMAN VALIDATION TO SHOW THAT

3232
02:05:33,565 --> 02:05:35,100
THE TARGET EXISTS IN HUMAN

3233
02:05:35,100 --> 02:05:36,302
CONDITION AND WORKS IN SIMILAR

3234
02:05:36,302 --> 02:05:38,470
WAY TO WHAT'S BEING DONE ON

3235
02:05:38,470 --> 02:05:40,105
MECHANISTIC EXPERIMENTS INSIDE

3236
02:05:40,105 --> 02:05:41,740
THE MODEL SYSTEMS IN ORDER FOR

3237
02:05:41,740 --> 02:05:43,409
IT TO BE WORTHWHILE FOR THERE TO

3238
02:05:43,409 --> 02:05:46,011
BE INVESTMENT LATER IN IT.

3239
02:05:46,011 --> 02:05:48,547
SO WE -- YOU CAN SEE A PROGRAM

3240
02:05:48,547 --> 02:05:51,083
LEADS ON LOWER LEFT-HAND CORNER

3241
02:05:51,083 --> 02:05:52,918
OF THE SLIDE HERE.

3242
02:05:52,918 --> 02:05:53,886
THE PRECISION HUMAN PAIN

3243
02:05:53,886 --> 02:05:56,088
NETWORK, I'M NOT GOING TO READ

3244
02:05:56,088 --> 02:05:57,956
THROUGH WHAT PRECISION STANDS

3245
02:05:57,956 --> 02:05:58,123
FOR.

3246
02:05:58,123 --> 02:05:59,024
VERY INTERESTING ACRONYM OVER

3247
02:05:59,024 --> 02:05:59,958
THERE.

3248
02:05:59,958 --> 02:06:02,194
THE GOAL HERE IS TO GENERATE

3249
02:06:02,194 --> 02:06:02,528
DATASETS.

3250
02:06:02,528 --> 02:06:06,465
YES, I SAID THAT RIGHT.

3251
02:06:06,465 --> 02:06:10,202
DATASETS OF CELL TYPES,

3252
02:06:10,202 --> 02:06:11,537
MOLECULAR SIGNATURES AND

3253
02:06:11,537 --> 02:06:12,404
FUNCTIONAL TYPES, AND SHARE THAT

3254
02:06:12,404 --> 02:06:15,240
DATA IN ORDER FOR IT TO BE USED

3255
02:06:15,240 --> 02:06:17,776
FOR OTHER RESERVERS DOING THIS

3256
02:06:17,776 --> 02:06:19,845
DEVELOPMENT TO ENSURE THAT THEIR

3257
02:06:19,845 --> 02:06:24,750
TARGET IS IN THE HUMAN DRG.

3258
02:06:24,750 --> 02:06:27,720
THESE GROUPS ARE TAKING DRGs

3259
02:06:27,720 --> 02:06:29,488
FROM PATHOLOGIC SAMPLES FROM

3260
02:06:29,488 --> 02:06:31,123
INDIVIDUALS HAVING SURGERIES AND

3261
02:06:31,123 --> 02:06:40,199
HAVE DORSAL ROOT GANG  --

3262
02:06:40,199 --> 02:06:41,834
GANGLIA REMOVED, PROFILING WITH

3263
02:06:41,834 --> 02:06:42,601
OMICS TECHNIQUES, AND SHARING

3264
02:06:42,601 --> 02:06:45,204
THAT DATA, THE GOAL IS TO SHARE

3265
02:06:45,204 --> 02:06:47,639
THAT DATA.

3266
02:06:47,639 --> 02:06:50,376
WE'RE TAKING ADVANTAGE OF THE

3267
02:06:50,376 --> 02:06:51,910
SPARC PORTAL FOR THE DATA IN

3268
02:06:51,910 --> 02:06:53,078
THIS PARTICULAR GROUP.

3269
02:06:53,078 --> 02:06:55,414
THERE'S A LOT OF DATA

3270
02:06:55,414 --> 02:07:02,855
COORDINATION HAPPENING ACROSS 

3271
02:07:02,855 --> 02:07:03,856
ACROSS "HEAL."

3272
02:07:03,856 --> 02:07:06,024
NINDS WAS INVOLVED WITH SPARC,

3273
02:07:06,024 --> 02:07:07,893
THEY DEVELOPED A NICE PLATFORM,

3274
02:07:07,893 --> 02:07:08,761
NICE FRONT END.

3275
02:07:08,761 --> 02:07:11,363
SPARC PROGRAM BEING USED IN

3276
02:07:11,363 --> 02:07:12,798
SEVERAL PROGRAMS.

3277
02:07:12,798 --> 02:07:14,400
AND THAT DATA COORDINATING

3278
02:07:14,400 --> 02:07:20,005
CENTER , THAT'S THE GOAL,

3279
02:07:20,005 --> 02:07:20,806
DEVELOPING THE PLATFORM FOR

3280
02:07:20,806 --> 02:07:22,307
SHARING THAT FOR PEOPLE TO

3281
02:07:22,307 --> 02:07:23,409
BENEFIT FROM IT.

3282
02:07:23,409 --> 02:07:25,277
THERE'S EVEN A GROUP HERE THAT

3283
02:07:25,277 --> 02:07:26,912
BENEFITED ANOTHER PROGRAM THAT

3284
02:07:26,912 --> 02:07:31,183
I'M GOING TO TO SHOW WHERE HUMAN

3285
02:07:31,183 --> 02:07:32,284
VALIDATION IS MAKING A

3286
02:07:32,284 --> 02:07:33,685
DIFFERENCE IN DEVELOPMENT

3287
02:07:33,685 --> 02:07:34,119
PROGRAMS.

3288
02:07:34,119 --> 02:07:35,354
NEXT SLIDE.

3289
02:07:35,354 --> 02:07:39,057
BEFORE I JUMP TO THAT I WANT TO

3290
02:07:39,057 --> 02:07:43,462
GIVE A SHOUT OUT TO THE RE-JOIN

3291
02:07:43,462 --> 02:07:46,298
CONSORTIUM WHICH DR. LANGEVIN

3292
02:07:46,298 --> 02:07:46,965
HAD SPOKEN ABOUT.

3293
02:07:46,965 --> 02:07:48,600
I WANT TO POINT OUT IMPORTANCE

3294
02:07:48,600 --> 02:07:51,103
OF WHAT WE'RE GENERATING.

3295
02:07:51,103 --> 02:07:52,671
WE'RE GENERATING AN

3296
02:07:52,671 --> 02:07:54,973
UNDERSTANDING OF THE MULTIPLE

3297
02:07:54,973 --> 02:07:56,175
TISSUES THAT ARE INVOLVED IN

3298
02:07:56,175 --> 02:07:57,376
PAIN OR THAT ARE POTENTIALLY

3299
02:07:57,376 --> 02:07:59,111
INVOLVED IN THE PAIN.

3300
02:07:59,111 --> 02:08:00,979
LOOKING FOR THE SOURCE OF THEM,

3301
02:08:00,979 --> 02:08:10,489
NOT JUST THE NERVE, BUT THE 

3302
02:08:10,489 --> 02:08:13,659
BONE, CARTILAGE, SYNOVIAL, JOINT

3303
02:08:13,659 --> 02:08:14,626
CAPSULE AND LIGAMENTS.

3304
02:08:14,626 --> 02:08:16,395
IN THE KNEE, EVEN ONE OF THE

3305
02:08:16,395 --> 02:08:19,031
PROJECTS THAT DOES BOTH, SO WE

3306
02:08:19,031 --> 02:08:21,667
CAN COMPARE DATA ACROSS THEM AND

3307
02:08:21,667 --> 02:08:23,202
VALIDATE WHAT'S BEING DISCOVERED

3308
02:08:23,202 --> 02:08:25,504
THERE AND ASK THE QUESTION, HOW

3309
02:08:25,504 --> 02:08:29,441
COULD THAT LEAD TO

3310
02:08:29,441 --> 02:08:32,711
INTERVENTIONS, NOT JUST OF

3311
02:08:32,711 --> 02:08:37,649
MOLECULAR NATURE OF SMALL 

3312
02:08:37,649 --> 02:08:40,052
MOLECULES OR BIOLOGICS, THIS

3313
02:08:40,052 --> 02:08:41,787
DATA WILL BE SHARED THROUGH THE

3314
02:08:41,787 --> 02:08:43,889
SPARC PORTAL WE MENTIONED

3315
02:08:43,889 --> 02:08:44,122
EARLIER.

3316
02:08:44,122 --> 02:08:46,492
THIS RE-JOIN HAS A DATA

3317
02:08:46,492 --> 02:08:47,726
COORDINATING GROUP THAT WILL BE

3318
02:08:47,726 --> 02:08:49,461
RESPONSIBLE FOR THAT.

3319
02:08:49,461 --> 02:08:52,397
SHARING THE DATA, HAVING MORE

3320
02:08:52,397 --> 02:08:53,932
RESEARCH, MORE ACCOMPLISHMENTS

3321
02:08:53,932 --> 02:08:55,067
HAPPEN, AFTER WE FUND THESE

3322
02:08:55,067 --> 02:08:58,403
PROJECTS BECAUSE IT WILL SEED

3323
02:08:58,403 --> 02:09:01,406
FUTURE PROJECTS.

3324
02:09:01,406 --> 02:09:02,374
NEXT SLIDE.

3325
02:09:02,374 --> 02:09:06,144
SO NOW WE COME TO OUR "HEAL"

3326
02:09:06,144 --> 02:09:06,879
PAIN THERAPEUTICS DEVELOPMENT

3327
02:09:06,879 --> 02:09:07,212
PROGRAM.

3328
02:09:07,212 --> 02:09:10,382
REALLY ONE OF OUR FLAGSHIP

3329
02:09:10,382 --> 02:09:10,716
PROGRAMS.

3330
02:09:10,716 --> 02:09:13,418
WE HAVE AN EARLY TRANSLATIONAL

3331
02:09:13,418 --> 02:09:15,287
EFFORT PORTION OF THAT THAT'S

3332
02:09:15,287 --> 02:09:24,162
LED BY DR. JULIA BACHMAN AND THE

3333
02:09:24,162 --> 02:09:32,671
PORTION LED BY DR.  MARY ANN 

3334
02:09:32,671 --> 02:09:33,171
PELLYMOUNTER.

3335
02:09:33,171 --> 02:09:35,207
STAY TUNED TO HEAR HOW THAT

3336
02:09:35,207 --> 02:09:35,807
WENT.

3337
02:09:35,807 --> 02:09:38,610
AND THEN WE HAVE THESE ONES THAT

3338
02:09:38,610 --> 02:09:41,880
ARE IN A PROGRAM WHERE WE BUILD

3339
02:09:41,880 --> 02:09:43,282
A CONSULTING TEAM AROUND THE

3340
02:09:43,282 --> 02:09:45,584
GROUP THAT HAS AN ASSET, HELPS

3341
02:09:45,584 --> 02:09:49,121
THEM WITH OUR NINDS CONTRACTS,

3342
02:09:49,121 --> 02:09:51,757
TO ALL THE IND-ENABLING STUDIES

3343
02:09:51,757 --> 02:09:54,226
AFTER LEAD SELECTION HAS BEEN

3344
02:09:54,226 --> 02:09:57,195
MADE IN ORDER TO PREPARE FOR FDA

3345
02:09:57,195 --> 02:09:58,230
FILING AND DO THE PHASE 1

3346
02:09:58,230 --> 02:09:58,830
CLINICAL TRIAL.

3347
02:09:58,830 --> 02:10:01,700
IF YOU GO TO THE NEXT SLIDE

3348
02:10:01,700 --> 02:10:05,938
YOU'LL SEE THAT WE HAVE A VERY

3349
02:10:05,938 --> 02:10:11,410
DIVERSE PORTFOLIO OF PROJECTS

3350
02:10:11,410 --> 02:10:13,178
AND TARGETS INSIDE THIS PTDP

3351
02:10:13,178 --> 02:10:13,879
PROGRAM.

3352
02:10:13,879 --> 02:10:15,614
WE HAVE SEVERAL ASSETS YOU CAN

3353
02:10:15,614 --> 02:10:17,783
SEE AT THE BOTTOM THAT ARE

3354
02:10:17,783 --> 02:10:20,185
REPURPOSED, IF YOU WILL.

3355
02:10:20,185 --> 02:10:26,325
WE EVEN HAVE A CONTACT LENS AND

3356
02:10:26,325 --> 02:10:28,393
VALIDATING FOR EYE SURGERIES.

3357
02:10:28,393 --> 02:10:35,300
THERE'S EYE SURGERIES

3358
02:10:35,300 --> 02:10:40,539
TREMENDOUSLY PAINFUL, LET'S SAY 

3359
02:10:40,539 --> 02:10:42,274
-- THERE'S EYE SURGERIES WITH

3360
02:10:42,274 --> 02:10:43,909
PAIN AFTER SURGERY, THE ONLY WAY

3361
02:10:43,909 --> 02:10:46,111
TO TREAT THOSE THREE TO FIVE

3362
02:10:46,111 --> 02:10:49,081
DAYS IS OPIOIDS, HIGH DOSE

3363
02:10:49,081 --> 02:10:49,381
OPIOIDS.

3364
02:10:49,381 --> 02:10:52,551
AND THAT'S HOW THEY BENEFIT.

3365
02:10:52,551 --> 02:10:55,320
THANK YOU, RETINAL DETACHMENT

3366
02:10:55,320 --> 02:10:56,188
ALSO.

3367
02:10:56,188 --> 02:10:59,558
THEY HAVE ALMOST ALWAYS -- THEY

3368
02:10:59,558 --> 02:11:05,397
SCRATCH THE EYE AND THEY DO UV

3369
02:11:05,397 --> 02:11:06,698
TREATMENT TO CROSS-LINK

3370
02:11:06,698 --> 02:11:07,666
PROTEINS, AND PUT A CONTACT LENS

3371
02:11:07,666 --> 02:11:09,635
ON TOP OF THE EYE TO HOLD THE

3372
02:11:09,635 --> 02:11:11,770
SHAPE OF THE LENS THERE BUT THEY

3373
02:11:11,770 --> 02:11:14,106
JUST PUT A PATCH OVER IT.

3374
02:11:14,106 --> 02:11:17,609
THE PATIENT HAS TO TRY NOT TO

3375
02:11:17,609 --> 02:11:19,911
SCRATCH, ET CETERA.

3376
02:11:19,911 --> 02:11:24,049
THIS PARTICULAR CONTACT LENS

3377
02:11:24,049 --> 02:11:34,526
WILL BE  ALLUDING TETRIKANE,

3378
02:11:35,961 --> 02:11:36,328
REVOLUTIONARY.

3379
02:11:36,328 --> 02:11:39,164
YOU MIGHT SEE TARGETS LOOKED AT

3380
02:11:39,164 --> 02:11:40,799
BEFORE THROUGH THESE, VETTING

3381
02:11:40,799 --> 02:11:45,303
THESE PROJECTS, LET'S SAY CB1,

3382
02:11:45,303 --> 02:11:47,506
SPECIFIC ONES THAT AREN'T

3383
02:11:47,506 --> 02:11:50,575
DUPLICATING WORK DONE BEFORE BUT

3384
02:11:50,575 --> 02:11:51,677
ADD SOMETHING NEW OR

3385
02:11:51,677 --> 02:11:54,713
REVOLUTIONARY TO THE PROJECT.

3386
02:11:54,713 --> 02:11:59,551
IN THIS CASE POSITIVE

3387
02:11:59,551 --> 02:12:06,992
ALLOSTEERIC MODULATOR AND OTHERS

3388
02:12:06,992 --> 02:12:11,363
THAT ARE PERIPHERALLY

3389
02:12:11,363 --> 02:12:11,663
RESTRICTED.

3390
02:12:11,663 --> 02:12:12,864
LET'S TALK ABOUT WINS IN THE

3391
02:12:12,864 --> 02:12:13,432
PROGRAM.

3392
02:12:13,432 --> 02:12:15,934
ON THE RIGHT SIDE, MYC 1

3393
02:12:15,934 --> 02:12:20,639
INHIBITORS, THIS IS FROM A

3394
02:12:20,639 --> 02:12:22,207
COMPANY, THERE WAS A RECENT

3395
02:12:22,207 --> 02:12:26,011
PAPER FROM ONE OF THE GROUPS

3396
02:12:26,011 --> 02:12:28,613
THAT ARE LEADING A TEAM IN THE

3397
02:12:28,613 --> 02:12:29,614
PRECISION PROGRAM, THIS

3398
02:12:29,614 --> 02:12:35,420
PARTICULAR TARGET IS IN HUMAN

3399
02:12:35,420 --> 02:12:37,856
TISSUES, THIS MNK INHIBITOR IS

3400
02:12:37,856 --> 02:12:39,257
DOWNSTREAM IF YOU LOOK AT THE

3401
02:12:39,257 --> 02:12:48,366
TOP FIGURE ON THE RIGHT, IL-6,

3402
02:12:48,366 --> 02:12:50,435
LOTS OF THINGS ARE INVOLVED IN

3403
02:12:50,435 --> 02:12:57,442
THE PAIN PATHWAY.

3404
02:12:57,442 --> 02:12:59,511
AND THIS MNK-1 IS DOWNSTREAM,

3405
02:12:59,511 --> 02:13:01,046
THEY HAVE A LOT OF POTENTIAL TO

3406
02:13:01,046 --> 02:13:09,988
BE USED FOR MANY DIFFERENT PAIN 

3407
02:13:09,988 --> 02:13:10,288
DISORDERS.

3408
02:13:10,288 --> 02:13:14,459
NEUROPATHIC PAIN.

3409
02:13:14,459 --> 02:13:19,197
LEFT INTRATHECAL DELIVERY, NOSI

3410
02:13:19,197 --> 02:13:21,733
SEPTIN-1, NOT A MU OPIOID, IT'S

3411
02:13:21,733 --> 02:13:26,972
NOT REINFORCING, DOESN'T HAVE

3412
02:13:26,972 --> 02:13:29,207
THAT ADDICTION LIABILITY.

3413
02:13:29,207 --> 02:13:30,609
FOR INTRATHECAL APPLICATION TO

3414
02:13:30,609 --> 02:13:32,944
TURN OFF THE PAIN, BEFORE IT

3415
02:13:32,944 --> 02:13:36,882
GETS TO THE HIGH BRAIN CENTERS,

3416
02:13:36,882 --> 02:13:39,184
THE PATIENT CAN PERCEIVE IT, TWO

3417
02:13:39,184 --> 02:13:40,152
PROGRAMS READY FOR IND

3418
02:13:40,152 --> 02:13:41,153
SUBMISSIONS THIS MONTH.

3419
02:13:41,153 --> 02:13:47,926
THAT'S COMING THROUGH OUR 

3420
02:13:47,926 --> 02:13:48,260
PROGRAM.

3421
02:13:48,260 --> 02:13:49,494
NEXT SLIDE.

3422
02:13:49,494 --> 02:13:53,165
THAT'S BACKWARDS.

3423
02:13:53,165 --> 02:13:54,633
PLEASE GO FORWARD.

3424
02:13:54,633 --> 02:13:56,034
PSPP PROGRAM, THAT'S RIGHT.

3425
02:13:56,034 --> 02:13:58,003
NEXT THING I WANT TO HIGHLIGHT

3426
02:13:58,003 --> 02:14:01,406
IS THE PSPP PROGRAM,

3427
02:14:01,406 --> 02:14:02,040
PRE-CLINICAL SCREENING PLATFORM

3428
02:14:02,040 --> 02:14:04,576
FOR PAIN, YOU MIGHT BE FAMILIAR

3429
02:14:04,576 --> 02:14:06,111
WITH EPILEPSY SCREENING PROGRAM

3430
02:14:06,111 --> 02:14:11,383
FOR 40 YEARS, WE DEVELOPED WITH

3431
02:14:11,383 --> 02:14:18,390
THE HEAL INITIATIVE FUNDS,

3432
02:14:18,390 --> 02:14:21,459
PLATFORM SCREENING PROGRAM FOR

3433
02:14:21,459 --> 02:14:24,196
PAIN, 11 OPTIMIZED MODELS WITH 4

3434
02:14:24,196 --> 02:14:24,830
OPTIMIZED ENDPOINTS.

3435
02:14:24,830 --> 02:14:26,765
I WANT TO POINT OUT NOW THAT THE

3436
02:14:26,765 --> 02:14:35,874
LINK YOU SEE ON THE SCREEN HERE

3437
02:14:35,874 --> 02:14:38,643
HAS THE DATA FOR THE CONTROLS,

3438
02:14:38,643 --> 02:14:39,444
POSITIVE AND NEGATIVE CONTROLS,

3439
02:14:39,444 --> 02:14:45,417
THAT ARE USED IN THE PROGRAM

3440
02:14:45,417 --> 02:14:50,589
FROM CARBON MAZEAPEN, DIAZEPAM,

3441
02:14:50,589 --> 02:14:53,859
MORPHINE, NAPROXIN], ET CETERA,

3442
02:14:53,859 --> 02:14:54,626
FOR SHOWING VALIDATIONS USING

3443
02:14:54,626 --> 02:14:55,927
DRUGS SO OTHER GROUPS CAN

3444
02:14:55,927 --> 02:15:04,603
BENEFIT IF THEY ARE USING THEM

3445
02:15:04,603 --> 02:15:05,904
INTERNALLY, THE TECHNIQUES CAN

3446
02:15:05,904 --> 02:15:09,074
BE REPRODUCED, WHAT IT SHOULD 

3447
02:15:09,074 --> 02:15:11,142
LOOK LIKE IN RESPONSE TO

3448
02:15:11,142 --> 02:15:14,846
POSITIVE AND NEGATIVE CONTROL,

3449
02:15:14,846 --> 02:15:16,615
POSITIVE AND NEGATIVE CONTROLS

3450
02:15:16,615 --> 02:15:17,349
INCLUDING BLINDING AND RIGOROUS

3451
02:15:17,349 --> 02:15:19,684
METHODS YOU CAN EXPECT.

3452
02:15:19,684 --> 02:15:22,988
THIS PROGRAM HAS INTERACTED WITH

3453
02:15:22,988 --> 02:15:24,623
MORE THAN 180 ACADEMIC AND

3454
02:15:24,623 --> 02:15:25,490
COMPANIES AT THIS POINT.

3455
02:15:25,490 --> 02:15:29,861
THERE ARE CURRENTLY IN THE

3456
02:15:29,861 --> 02:15:30,729
PROCESS OF EVALUATING 31 ASSETS,

3457
02:15:30,729 --> 02:15:32,597
AND THERE'S SOME THAT HAVE

3458
02:15:32,597 --> 02:15:33,498
DISCONTINUED BECAUSE SOME ARE

3459
02:15:33,498 --> 02:15:34,699
NOT GOING TO WORK.

3460
02:15:34,699 --> 02:15:37,736
WE'RE PROVIDING THAT DATA FOR

3461
02:15:37,736 --> 02:15:41,806
THE GROUPS IN PROTECTED PRIVATE

3462
02:15:41,806 --> 02:15:45,310
WAY, THE BENEFIT SO THEY CAN USE

3463
02:15:45,310 --> 02:15:47,579
THEIR PRIVATE FUNDS FOR

3464
02:15:47,579 --> 02:15:48,780
ACCELERATING DEVELOPMENT IF THEY

3465
02:15:48,780 --> 02:15:50,882
SEE POSITIVE DATA FROM HERE.

3466
02:15:50,882 --> 02:15:54,052
THAT'S THE GOAL OF THE PROGRAM.

3467
02:15:54,052 --> 02:15:56,688
ALSO, THE PROFILING, NOT JUST

3468
02:15:56,688 --> 02:15:58,556
AROUND PAIN BUT ALSO FOR

3469
02:15:58,556 --> 02:16:03,561
OFF-TARGET AND SIDE EFFECTS

3470
02:16:03,561 --> 02:16:06,197
USING THE IRWIN TEST ET CETERA.

3471
02:16:06,197 --> 02:16:06,865
NEXT SLIDE.

3472
02:16:06,865 --> 02:16:10,268
SO THE LAST THING I WANT TO SHOW

3473
02:16:10,268 --> 02:16:12,237
IS SOME NEW PROGRAMS AND DO

3474
02:16:12,237 --> 02:16:13,638
CONCEPT CLEARANCE.

3475
02:16:13,638 --> 02:16:18,877
ONE IS AN R15 PROGRAM TO SUPPORT

3476
02:16:18,877 --> 02:16:20,645
UNDERREPRESENTED PAIN

3477
02:16:20,645 --> 02:16:23,515
RESEARCHERS AND DIVERSE TRAINEES

3478
02:16:23,515 --> 02:16:24,282
IN UNDERGRADUATE FOCUSED

3479
02:16:24,282 --> 02:16:25,917
PROFESSIONAL SCHOOLS AND HAVE

3480
02:16:25,917 --> 02:16:27,552
THEM COLLABORATE WITH OTHER

3481
02:16:27,552 --> 02:16:29,187
INSTITUTIONS THAT ARE MAYBE

3482
02:16:29,187 --> 02:16:31,957
DOING CLINICAL PAIN RESEARCH TO

3483
02:16:31,957 --> 02:16:34,893
REALLY SEED THE PIPELINE FOR

3484
02:16:34,893 --> 02:16:36,528
PAIN RESEARCHERS AT AN EARLY

3485
02:16:36,528 --> 02:16:36,895
STAGE.

3486
02:16:36,895 --> 02:16:39,931
THAT'S ONE PROGRAM LED BY NCCIH.

3487
02:16:39,931 --> 02:16:45,203
SECOND IS STUDIES TO ENABLE

3488
02:16:45,203 --> 02:16:47,038
ANALGESIC DEVELOPMENT, THIS IS A

3489
02:16:47,038 --> 02:16:49,240
REISSUE AND NOT A NEW PROGRAM

3490
02:16:49,240 --> 02:16:51,309
BUT TO ENCOURAGE THESE INITIAL

3491
02:16:51,309 --> 02:16:52,844
TRANSLATIONAL EFFORTS THAT WILL

3492
02:16:52,844 --> 02:16:54,612
SUPPORT DRUG DISCOVERY PROGRAMS

3493
02:16:54,612 --> 02:16:57,983
AND ADVANCE PROJECTS AND PREPARE

3494
02:16:57,983 --> 02:16:59,851
THEM FOR THAT PTDP WHICH I

3495
02:16:59,851 --> 02:17:02,053
SHOWED A SHRINE ON.

3496
02:17:02,053 --> 02:17:09,361
THANK YOU FOR YOUR ATTENTION.

3497
02:17:09,361 --> 02:17:10,695
>> THANK YOU, MICHAEL.

3498
02:17:10,695 --> 02:17:12,530
LET'S TAKE QUESTIONS.

3499
02:17:12,530 --> 02:17:12,831
TIM?

3500
02:17:12,831 --> 02:17:13,631
>> THANK YOU, MICHAEL.

3501
02:17:13,631 --> 02:17:16,368
I LEARN A TON LISTENING TO YOU.

3502
02:17:16,368 --> 02:17:19,104
IT'S NOT MY FIELD BUT I WAS

3503
02:17:19,104 --> 02:17:21,272
CURIOUS, WHEN YOU DESCRIBE THE

3504
02:17:21,272 --> 02:17:23,808
DE-RISKING EFFORTS WHICH

3505
02:17:23,808 --> 02:17:27,178
ESPECIALLY FOR THE LOW ABUSE

3506
02:17:27,178 --> 02:17:29,481
POTENTIAL DRUGS ABANDONED, DO

3507
02:17:29,481 --> 02:17:30,482
YOU HAVE CONCRETE EXAMPLES HOW

3508
02:17:30,482 --> 02:17:32,317
MANY TIMES IT'S TURNED OUT

3509
02:17:32,317 --> 02:17:35,553
TARGET THAT HAD BEEN VALIDATED

3510
02:17:35,553 --> 02:17:36,721
EXQUISITELY IN ANIMAL MODEL

3511
02:17:36,721 --> 02:17:38,156
TURNED OUT TO SIMPLY NOT BE IN

3512
02:17:38,156 --> 02:17:41,726
THE HUMAN TISSUE THAT MATTERED?

3513
02:17:41,726 --> 02:17:43,828
THAT'S WHAT WAS EXPECTED OUTCOME

3514
02:17:43,828 --> 02:17:48,033
FROM HAVING THIS KIND OF OMICS

3515
02:17:48,033 --> 02:17:48,233
STUFF.

3516
02:17:48,233 --> 02:17:50,068
>> YEAH, SO THERE ARE
CLEAR

3517
02:17:50,068 --> 02:17:52,470
EXAMPLES OF THINGS THAT WORKED

3518
02:17:52,470 --> 02:17:53,605
TREMENDOUSLY WELL.

3519
02:17:53,605 --> 02:17:55,740
AND ALTHOUGH THEY MIGHT BE IN

3520
02:17:55,740 --> 02:17:57,709
THE HUMAN CONDITION, THEY

3521
02:17:57,709 --> 02:17:58,743
REACTED DIFFERENTLY.

3522
02:17:58,743 --> 02:18:00,645
PHYSIOLOGY WAS DIFFERENT.

3523
02:18:00,645 --> 02:18:04,282
ONE IS SUBSTANCE P EXAMPLE,

3524
02:18:04,282 --> 02:18:04,916
ANTAGONIST WORKED TREMENDOUSLY

3525
02:18:04,916 --> 02:18:05,917
WELL IN THE ANIMAL MODELS.

3526
02:18:05,917 --> 02:18:08,686
AND THEN WHEN IT CAME TO TESTING

3527
02:18:08,686 --> 02:18:10,855
THEM IN THE HUMAN, CLINICAL

3528
02:18:10,855 --> 02:18:12,824
TRIALS, THEY JUST FELL FLAT ON

3529
02:18:12,824 --> 02:18:14,159
THEIR FACE.

3530
02:18:14,159 --> 02:18:19,297
ONE EXAMPLE OF THAT.

3531
02:18:19,297 --> 02:18:20,065
THERE ARE DIFFERENT

3532
02:18:20,065 --> 02:18:21,566
REPRESENTATIONS OF THE SODIUM

3533
02:18:21,566 --> 02:18:24,235
CHANNELS IN DIFFERENT PARTS OF

3534
02:18:24,235 --> 02:18:27,839
THE GANGLIA OR CELL TYPES.

3535
02:18:27,839 --> 02:18:30,775
THE MAIN GOAL OF THE PRECISION

3536
02:18:30,775 --> 02:18:32,077
PROGRAM IS TO ELUCIDATE

3537
02:18:32,077 --> 02:18:34,379
DIFFERENCES SO WE CAN PREVENT

3538
02:18:34,379 --> 02:18:43,121
GOING TO THE CLINICAL TRIALS AND

3539
02:18:43,121 --> 02:18:45,223
WASTING LATER DEVELOPMENT.

3540
02:18:45,223 --> 02:18:47,158
>> I HEARD WALTER SAY WE
HAVE TO

3541
02:18:47,158 --> 02:18:49,260
CURE OUR IGNORANCE FIRST BEFORE

3542
02:18:49,260 --> 02:18:50,428
WE CAN SUCCESSFULLY CURE A LOT

3543
02:18:50,428 --> 02:18:53,398
OF DISEASES BECAUSE THERE'S SO

3544
02:18:53,398 --> 02:18:55,700
MANY UNKNOWNS IN THE END, EVEN

3545
02:18:55,700 --> 02:18:57,135
WHEN YOU HAVE A TARGET ABOUT THE

3546
02:18:57,135 --> 02:18:58,770
CONTEXT HOW IT WORKS WE WANT TO

3547
02:18:58,770 --> 02:19:00,638
JUMP AHEAD HOPEFULLY TO THERAPY

3548
02:19:00,638 --> 02:19:04,709
BUT USELY  -- USUALLY THAT'S

3549
02:19:04,709 --> 02:19:08,012
WHERE THE RISK IS.

3550
02:19:08,012 --> 02:19:09,114
>> ANGIOTENSIN RECEPTORS
HAVE

3551
02:19:09,114 --> 02:19:10,949
DIFFERENT EFFECT, THEY WERE

3552
02:19:10,949 --> 02:19:13,017
WORKED UP BECAUSE OF

3553
02:19:13,017 --> 02:19:14,018
PRE-CLINICAL DATA AND DIDN'T

3554
02:19:14,018 --> 02:19:16,287
EXIST IN CELL TYPES IMPORTANT IN

3555
02:19:16,287 --> 02:19:17,155
HUMANS, ANOTHER EXAMPLE.

3556
02:19:17,155 --> 02:19:21,025
>> THANK YOU.

3557
02:19:21,025 --> 02:19:22,560
>> THANK YOU, MICHAEL.

3558
02:19:22,560 --> 02:19:24,195
I WANT TO NOTE, WE'RE ACTUALLY

3559
02:19:24,195 --> 02:19:27,065
GOING TO TAKE A VOTE ON THE

3560
02:19:27,065 --> 02:19:34,639
CONCEPT BUS WE'RE GOING TO DO 

3561
02:19:34,639 --> 02:19:39,210
THAT TO DO THAT AFTER LINDA'S

3562
02:19:39,210 --> 02:19:39,544
PRESENTATION.

3563
02:19:39,544 --> 02:19:41,479
>> AM I OKAY TO START?

3564
02:19:41,479 --> 02:19:43,681
YEAH, OKAY, GREAT.

3565
02:19:43,681 --> 02:19:45,116
SO, THANK YOU TO HELENE AND

3566
02:19:45,116 --> 02:19:48,052
MICHAEL FOR SETTING UP THE NEXT

3567
02:19:48,052 --> 02:19:53,758
PART OF THE "HEAL" UPDATE.

3568
02:19:53,758 --> 02:19:54,425
NEXT SLIDE PLEASE.

3569
02:19:54,425 --> 02:19:56,461
I WANT TO TAKE A STEP BACK AND

3570
02:19:56,461 --> 02:19:57,629
GIVE YOU BETTER UNDERSTAND OF

3571
02:19:57,629 --> 02:19:59,631
WHY WE'RE TALKING SO MUCH ABOUT

3572
02:19:59,631 --> 02:20:01,266
PAIN TODAY AND HOW IMPORTANT IT

3573
02:20:01,266 --> 02:20:05,003
IS THAT WE REALLY EXPAND OUR

3574
02:20:05,003 --> 02:20:05,770
RESEARCH PORTFOLIO HERE.

3575
02:20:05,770 --> 02:20:07,639
AND SO A LITTLE BIT OF

3576
02:20:07,639 --> 02:20:08,940
POPULATION LEVEL DATA MIGHT HELP

3577
02:20:08,940 --> 02:20:13,211
TO PUT THAT INTO PERSPECTIVE.

3578
02:20:13,211 --> 02:20:16,381
PAIN IS NOW THE MOST COMMON

3579
02:20:16,381 --> 02:20:19,684
REASON THAT PEOPLE SEEK MEDICAL

3580
02:20:19,684 --> 02:20:21,186
CARE, VARIOUS DIFFERENT

3581
02:20:21,186 --> 02:20:22,086
SETTINGS.

3582
02:20:22,086 --> 02:20:27,992
IT'S COSTING US ABOUT $600

3583
02:20:27,992 --> 02:20:32,263
BILLION A YEAR INCLUDING LOST 

3584
02:20:32,263 --> 02:20:33,598
PRODUCTIVITY AND HEALTH CARE

3585
02:20:33,598 --> 02:20:34,432
EXPENSES.

3586
02:20:34,432 --> 02:20:36,100
THE CHART ON THE RIGHT-HAND SIDE

3587
02:20:36,100 --> 02:20:38,703
GIVES AN IDEA PRESCRIPTION

3588
02:20:38,703 --> 02:20:40,238
OPIOIDS ARE STILL INVOLVED IN

3589
02:20:40,238 --> 02:20:44,742
MANY OF THE OVERDOSE DEATHS THAT

3590
02:20:44,742 --> 02:20:46,711
EITHER ARE PRESCRIPTION OPIOID

3591
02:20:46,711 --> 02:20:49,214
ONLY RELATED OVERDOSE DEATHS OR

3592
02:20:49,214 --> 02:20:51,983
PRESCRIPTION OPIOIDS WITH

3593
02:20:51,983 --> 02:20:53,151
OTHER -- SOME OTHER TYPE OF

3594
02:20:53,151 --> 02:20:55,687
DRUGS INVOLVED IN IT.

3595
02:20:55,687 --> 02:21:00,925
SO THE YELLOW LINE ON THE BOTTOM

3596
02:21:00,925 --> 02:21:02,794
ARE THOSE THAT ARE PRESCRIPTION

3597
02:21:02,794 --> 02:21:04,329
PLUS OTHERS, AND IT'S GREEN LINE

3598
02:21:04,329 --> 02:21:06,731
THROUGH THE BLUE BARS SHOWS A

3599
02:21:06,731 --> 02:21:08,800
PEAK AND DROP IN PRESCRIPTION

3600
02:21:08,800 --> 02:21:10,168
OPIOID INVOLVEMENT IN OVERDOSE

3601
02:21:10,168 --> 02:21:10,368
DEATH.

3602
02:21:10,368 --> 02:21:13,071
AND I THINK THIS WAS A LOT TO DO

3603
02:21:13,071 --> 02:21:15,873
WITH THE CHANGE IN PRESCRIBING

3604
02:21:15,873 --> 02:21:23,248
OF OPIOIDS AND MUCH TIGHTER

3605
02:21:23,248 --> 02:21:26,284
RESTRICTION WITH CONFLICTING

3606
02:21:26,284 --> 02:21:27,285
NEED TO CONTINUE PRESCRIBE FOR

3607
02:21:27,285 --> 02:21:28,920
THOSE THAT NEED IT AS PART OF

3608
02:21:28,920 --> 02:21:31,789
PAIN CARE MANAGEMENT.

3609
02:21:31,789 --> 02:21:33,191
NEXT SLIDE GIVES YOU A LITTLE

3610
02:21:33,191 --> 02:21:35,493
BIT OF SENSE OF NUMBERS OF

3611
02:21:35,493 --> 02:21:36,894
PEOPLE WHO ARE AFFECTED IN THE

3612
02:21:36,894 --> 02:21:37,462
POPULATION.

3613
02:21:37,462 --> 02:21:42,100
SO THE NATIONAL HEALTH INTERVIEW

3614
02:21:42,100 --> 02:21:44,235
SURVEY SHOW 50 MILLION ADULT WHO

3615
02:21:44,235 --> 02:21:45,436
IS REPORT CHRONIC PAIN, THAT'S

3616
02:21:45,436 --> 02:21:48,106
MEASURED PAIN OVER THE LAST

3617
02:21:48,106 --> 02:21:51,476
THREE MONTHS SINCE THE

3618
02:21:51,476 --> 02:21:51,876
INTERVIEW.

3619
02:21:51,876 --> 02:21:53,778
25 MILLION, SO HALF WITH CHRONIC

3620
02:21:53,778 --> 02:21:55,079
PAIN ARE AFFECTED BY PAIN,

3621
02:21:55,079 --> 02:21:58,249
SEVERE PAIN, ON A DAILY BASIS.

3622
02:21:58,249 --> 02:21:59,550
AND THEN WE LOOK AT HIGH IMPACT

3623
02:21:59,550 --> 02:22:01,753
CHRONIC PAIN WHICH IS DEFINED AS

3624
02:22:01,753 --> 02:22:03,521
PAIN OVER THE LAST THREE MONTHS

3625
02:22:03,521 --> 02:22:05,590
WHICH INTERFERES WITH YOUR LIFE.

3626
02:22:05,590 --> 02:22:07,258
SO YOU CAN'T GO TO SCHOOL OR

3627
02:22:07,258 --> 02:22:11,963
YOU'RE UNABLE TO GO TO WORK, 

3628
02:22:11,963 --> 02:22:12,730
SOCIAL ACTIVITIES DECLINE

3629
02:22:12,730 --> 02:22:14,132
BECAUSE OF OF THE STRONG EFFECT

3630
02:22:14,132 --> 02:22:18,403
OF CHRONIC PAIN ON YOUR LIFE.

3631
02:22:18,403 --> 02:22:20,305
CERTAIN POPULATIONS ARE MORE

3632
02:22:20,305 --> 02:22:21,372
AFFECTED THAN OTHER POPULATIONS.

3633
02:22:21,372 --> 02:22:23,341
THERE'S ONE PIECE OF DATA HERE

3634
02:22:23,341 --> 02:22:26,944
THAT THOSE WHO ARE IN RURAL

3635
02:22:26,944 --> 02:22:29,580
ENVIRONMENTS TEND TO REPORT MORE

3636
02:22:29,580 --> 02:22:30,782
PAIN, CHRONIC PAIN, AND HIGH

3637
02:22:30,782 --> 02:22:33,117
IMPACT PAIN, AND THAT'S PARTLY

3638
02:22:33,117 --> 02:22:34,852
AN ISSUE WITH ACCESS TO BETTER

3639
02:22:34,852 --> 02:22:36,521
HEALTH CARE IN SOME OF THESE

3640
02:22:36,521 --> 02:22:36,954
ENVIRONMENTS.

3641
02:22:36,954 --> 02:22:38,723
NOT ONLY IS THE PAIN CARE AN

3642
02:22:38,723 --> 02:22:40,458
ISSUE BUT THE ACCESS TO PAIN

3643
02:22:40,458 --> 02:22:41,559
CARE ALSO IS.

3644
02:22:41,559 --> 02:22:42,860
THESE ARE ALL THINGS THAT AS I

3645
02:22:42,860 --> 02:22:44,495
GO THROUGH THE TALK BRIEFLY I

3646
02:22:44,495 --> 02:22:47,365
WILL TRY TO GIVE AN IDEA HOW

3647
02:22:47,365 --> 02:22:49,000
"HEAL" IS BEGINNING TO AND

3648
02:22:49,000 --> 02:22:55,273
TRYING TO ADDRESS THESE ISSUES.

3649
02:22:55,273 --> 02:22:57,775
NEXT SLIDE PLEASE.

3650
02:22:57,775 --> 02:23:01,112
SO THIS SLIDE IS SOMEWHAT RECENT

3651
02:23:01,112 --> 02:23:03,481
STUDY SHOWING THAT ONCE YOU HAVE

3652
02:23:03,481 --> 02:23:07,018
PAIN, ONCE YOU HAVE CHRONIC

3653
02:23:07,018 --> 02:23:07,985
PAIN, HIGH IMPACT CHRONIC PAIN

3654
02:23:07,985 --> 02:23:10,922
IT DOESN'T GO AWAY AT POPULATION

3655
02:23:10,922 --> 02:23:11,689
LEVEL.

3656
02:23:11,689 --> 02:23:12,156
IT INCREASES.

3657
02:23:12,156 --> 02:23:15,760
THERE WAS A STUDY FROM NATIONAL

3658
02:23:15,760 --> 02:23:17,628
HEALTH INTERVIEW SURVEY WHICH

3659
02:23:17,628 --> 02:23:19,263
TOOK 2019 DATA, LOOKED APROS

3660
02:23:19,263 --> 02:23:23,101
PEOPLE WHO DON'T REPORT PAIN IN

3661
02:23:23,101 --> 02:23:24,635
BLACK, NEXT DARKER GRAY COLOR

3662
02:23:24,635 --> 02:23:26,371
PAIN BUT NOT CHRONIC, AND THEN

3663
02:23:26,371 --> 02:23:28,473
CHRONIC PAIN AND THE LIGHTEST

3664
02:23:28,473 --> 02:23:30,541
COLOR HIGH IMPACT CHRONIC PAIN.

3665
02:23:30,541 --> 02:23:33,144
THE INCIDENCE OF ALL THOSE GOES

3666
02:23:33,144 --> 02:23:37,849
UP, WHEN YOU GO BACK TO THE 2019

3667
02:23:37,849 --> 02:23:39,617
DATA, SUBPOPULATION, LOOK AT THE

3668
02:23:39,617 --> 02:23:41,586
2020 DATA, THE NEW INCIDENCE OF

3669
02:23:41,586 --> 02:23:44,088
CHRONIC PAIN IS VERY HIGH.

3670
02:23:44,088 --> 02:23:46,391
AND HIGH IMPACT CHRONIC PAIN AS

3671
02:23:46,391 --> 02:23:47,925
WELL, ACTUALLY GOES BEYOND THAT

3672
02:23:47,925 --> 02:23:50,328
COMPARED TO NEW INCIDENCE OF

3673
02:23:50,328 --> 02:23:52,730
DIABETES, DEPRESSION, HIGH BLOOD

3674
02:23:52,730 --> 02:23:54,399
PRESSURE, SOME OTHER REALLY

3675
02:23:54,399 --> 02:23:55,233
IMPORTANT CHRONIC CONDITIONS

3676
02:23:55,233 --> 02:23:56,134
ACROSS THE U.S.

3677
02:23:56,134 --> 02:23:59,070
WHAT YOU SEE IF YOU LOOK AT THE

3678
02:23:59,070 --> 02:24:00,872
GRAPH CAREFULLY IS THOSE THAT

3679
02:24:00,872 --> 02:24:04,142
DON'T REPORT PAIN, THE SAME 

3680
02:24:04,142 --> 02:24:06,210
PEOPLE WHO DIDN'T HAVE ANYTIME

3681
02:24:06,210 --> 02:24:08,479
2020 NOW REPORT NON-CHRONIC

3682
02:24:08,479 --> 02:24:09,914
PAIN, WITH NON-CHRONIC PAIN NOW

3683
02:24:09,914 --> 02:24:12,216
REPORTING CHRONIC PAIN.

3684
02:24:12,216 --> 02:24:13,985
THOSE WITH CHRONIC PAIN MORE NOW

3685
02:24:13,985 --> 02:24:15,620
REPORTING HIGH IMPACT CHRONIC

3686
02:24:15,620 --> 02:24:15,820
PAIN.

3687
02:24:15,820 --> 02:24:17,889
SO WE'RE NOT MAKING IT BETTER

3688
02:24:17,889 --> 02:24:20,758
AND WE'RE NOT MAKING IT GO AWAY.

3689
02:24:20,758 --> 02:24:23,594
THAT'S KIND OF THE OVERALL

3690
02:24:23,594 --> 02:24:24,262
MESSAGE FROM THIS PARTICULAR

3691
02:24:24,262 --> 02:24:24,796
SLIDE.

3692
02:24:24,796 --> 02:24:31,269
AND IF WE COULD GO TO THE NEXT

3693
02:24:31,269 --> 02:24:31,469
SLIDE.

3694
02:24:31,469 --> 02:24:32,870
WHAT I'D LIKE TO DO NOW IS GIVE

3695
02:24:32,870 --> 02:24:36,841
YOU SORT OF IN THE RED BLOCK

3696
02:24:36,841 --> 02:24:38,576
HERE REALLY HIGH LEVEL

3697
02:24:38,576 --> 02:24:40,445
HIGHLIGHTS OF WHAT "HEAL" IS

3698
02:24:40,445 --> 02:24:43,614
DOING TO ADDRESS THE PAIN CRISIS

3699
02:24:43,614 --> 02:24:47,251
IN THE U.S., AND ALL BASED ON

3700
02:24:47,251 --> 02:24:50,521
CLINICAL RESEARCH COMPONENT OF

3701
02:24:50,521 --> 02:24:50,888
"HEAL."

3702
02:24:50,888 --> 02:24:53,658
AND IF YOU LOOK WITHIN THAT RED

3703
02:24:53,658 --> 02:24:58,629
BOX YOU SEE THERE ARE BIOMARKER

3704
02:24:58,629 --> 02:25:00,798
PROGRAMS THAT ARE TO ASSESS PAIN

3705
02:25:00,798 --> 02:25:01,365
CONDITIONS, PROGRESS OF PAIN

3706
02:25:01,365 --> 02:25:03,768
CONDITIONS, ALSO TO BE USED IN

3707
02:25:03,768 --> 02:25:04,902
CLINICAL TRIALS.

3708
02:25:04,902 --> 02:25:06,938
HELENE TALKED ABOUT THE BACPAC

3709
02:25:06,938 --> 02:25:07,171
PROGRAM.

3710
02:25:07,171 --> 02:25:09,774
I'LL COME BACK TO THAT BRIEFLY.

3711
02:25:09,774 --> 02:25:12,877
AND THEN WE SET UP AND

3712
02:25:12,877 --> 02:25:14,045
ESTABLISHED TRIAL NETWORKS IN

3713
02:25:14,045 --> 02:25:16,547
"HEAL" WHERE WE CAN LOOK AT

3714
02:25:16,547 --> 02:25:18,382
DIFFERENT PHASES OF THE CLINICAL

3715
02:25:18,382 --> 02:25:21,619
TRIAL PROCESS, PHASE 2 STUDIES

3716
02:25:21,619 --> 02:25:23,754
TO LOOK AT SAFETY, EPPIC-NET

3717
02:25:23,754 --> 02:25:26,224
SYSTEM AND THEN WE DID A LARGE

3718
02:25:26,224 --> 02:25:28,626
TRIAL THROUGH A CONSORTIUM ON

3719
02:25:28,626 --> 02:25:31,329
KIDNEY DISEASE, AND THE PAIN

3720
02:25:31,329 --> 02:25:32,763
ASSOCIATED WITH DIALYSIS.

3721
02:25:32,763 --> 02:25:36,033
WE HAVE A COMPARATIVE

3722
02:25:36,033 --> 02:25:36,701
EFFECTIVENESS NETWORK.

3723
02:25:36,701 --> 02:25:38,402
PRAGMATIC TRIALS TO EMBED

3724
02:25:38,402 --> 02:25:40,872
INTERVENTIONS INTO HEALTH CARE

3725
02:25:40,872 --> 02:25:41,405
SYSTEMS.

3726
02:25:41,405 --> 02:25:44,242
BIG PROGRAM ON HEALTH EQUITIES

3727
02:25:44,242 --> 02:25:45,243
BECAUSE DIFFERENT POPULATIONS,

3728
02:25:45,243 --> 02:25:47,545
DISPARITIES, SEPARATE

3729
02:25:47,545 --> 02:25:48,412
DISPARITIES MORE LIKELY TO

3730
02:25:48,412 --> 02:25:51,282
REPORT PAIN AND CHRONIC PAIN.

3731
02:25:51,282 --> 02:25:55,219
WE'RE LOOKING AT COMORBIDITY, AT

3732
02:25:55,219 --> 02:25:56,654
INCLUDING -- MOVING ACCESS TO

3733
02:25:56,654 --> 02:26:01,025
PAIN CARE INTO RURAL

3734
02:26:01,025 --> 02:26:09,400
POPULATIONS, AND PEDIATRIC

3735
02:26:09,400 --> 02:26:09,834
PROGRAMS.

3736
02:26:09,834 --> 02:26:11,602
FUTURE REPORTS FOR RURAL PAIN

3737
02:26:11,602 --> 02:26:17,074
AND KIDS PAIN.

3738
02:26:17,074 --> 02:26:19,410
NEXT SLIDE, IF WE LOOK OVERALL

3739
02:26:19,410 --> 02:26:21,846
AT WHAT WE HAVE ADDRESSED AS FAR

3740
02:26:21,846 --> 02:26:25,082
AS PAIN CONDITIONS, IN THE

3741
02:26:25,082 --> 02:26:28,019
"HEAL" CLINICAL PAIN RESEARCH

3742
02:26:28,019 --> 02:26:30,021
NETWORK, YOU CAN SEE LIKE WHAT

3743
02:26:30,021 --> 02:26:31,556
PAIN CONDITIONS HAVE BEEN

3744
02:26:31,556 --> 02:26:34,258
ADDRESSED BY WHAT NUMBER OF

3745
02:26:34,258 --> 02:26:37,895
AWARDS THROUGH THE HEAL

3746
02:26:37,895 --> 02:26:39,096
INITIATIVE, AND THIS GRAPH IS

3747
02:26:39,096 --> 02:26:40,998
GROWING AS WE ADD MORE STUDIES

3748
02:26:40,998 --> 02:26:41,532
TO IT.

3749
02:26:41,532 --> 02:26:43,935
IT'S JUST TO GIVE AN OVERALL

3750
02:26:43,935 --> 02:26:46,938
SENSE OF IF WE INCLUDE ANYTHING

3751
02:26:46,938 --> 02:26:49,707
FROM LONGITUDINAL STUDIES DONE

3752
02:26:49,707 --> 02:26:51,375
THROUGH "HEAL," BIOMARKER

3753
02:26:51,375 --> 02:26:54,245
PROGRAMS, SOME OF THE PROGRAMS

3754
02:26:54,245 --> 02:26:55,112
THAT HELEN MENTIONED, MYOFASCIAL

3755
02:26:55,112 --> 02:26:57,281
PAIN ONE, THESE ARE PAIN

3756
02:26:57,281 --> 02:26:59,684
CONDITIONS BEING ADDRESSED

3757
02:26:59,684 --> 02:27:01,986
ACROSS THE WHOLE SPECTRUM OF

3758
02:27:01,986 --> 02:27:02,820
"HEAL" RESEARCH STUDIES.

3759
02:27:02,820 --> 02:27:05,590
WE'VE ALSO GOT MORE DATA ON WHAT

3760
02:27:05,590 --> 02:27:06,257
INTERVENTIONS ARE BEING TESTED.

3761
02:27:06,257 --> 02:27:07,959
THIS IS JUST TO GIVE AN IDEA OF

3762
02:27:07,959 --> 02:27:16,867
THE BREAD TH OF THE PROGRAM.

3763
02:27:16,867 --> 02:27:17,168
NEXT SLIDE.

3764
02:27:17,168 --> 02:27:18,402
"HEAL" RECOGNIZES THAT THERE ARE

3765
02:27:18,402 --> 02:27:21,272
CERTAIN POPULATIONS THAT ARE

3766
02:27:21,272 --> 02:27:23,774
MORE AFFECTED BY PAIN THAN

3767
02:27:23,774 --> 02:27:24,208
OTHERS.

3768
02:27:24,208 --> 02:27:27,278
AND ONE THAT IS VERY NOTICEABLE

3769
02:27:27,278 --> 02:27:30,047
IS THAT MORE WOMEN ARE AFFECTED

3770
02:27:30,047 --> 02:27:32,416
BY PAIN CONDITIONS THAT ARE

3771
02:27:32,416 --> 02:27:34,719
EITHER REALLY EXCLUSIVE TO WOMEN

3772
02:27:34,719 --> 02:27:37,455
OR MORE PREVALENT IN WOMEN.

3773
02:27:37,455 --> 02:27:38,189
AND "HEAL" RECOGNIZES THAT.

3774
02:27:38,189 --> 02:27:41,459
IF YOU LOOK AT THE GRAPH ON THE

3775
02:27:41,459 --> 02:27:43,027
RIGHT, YOU SEE TOTAL POPULATION

3776
02:27:43,027 --> 02:27:46,530
WITH CHRONIC PAIN, AND THAT WAS

3777
02:27:46,530 --> 02:27:49,700
HIGH IMPACT CHRONIC PAIN, DARK

3778
02:27:49,700 --> 02:27:52,336
BLUE IS TOTAL POPULATION, LIGHT

3779
02:27:52,336 --> 02:27:55,506
BLUE MEN, GREEN IS WOMEN.

3780
02:27:55,506 --> 02:27:58,009
YOU LOOK ON THE RIGHT-HAND SIDE

3781
02:27:58,009 --> 02:28:01,946
THE TYPES OF CONDITIONS AND THE

3782
02:28:01,946 --> 02:28:04,348
RELATIVE PREVALENCE OF THESE

3783
02:28:04,348 --> 02:28:07,652
CONDITIONS IN WOMEN AND IN MEN.

3784
02:28:07,652 --> 02:28:10,588
AND SO HEADACHE AND MIGRAINE,

3785
02:28:10,588 --> 02:28:12,657
PROGRAMS PARTICULARLY IN NINDS

3786
02:28:12,657 --> 02:28:14,058
THAT ADDRESS THIS.

3787
02:28:14,058 --> 02:28:16,394
THIS PARTICULAR CONDITION.

3788
02:28:16,394 --> 02:28:20,231
AND THEN THE OTHERS ON HERE ALL

3789
02:28:20,231 --> 02:28:22,199
"HEAL" HAS PROGRAMS OR PROJECTS

3790
02:28:22,199 --> 02:28:24,135
THAT ADDRESS EACH ONE OF THESE

3791
02:28:24,135 --> 02:28:31,842
OTHER PAIN CONDITIONS THAT ARE

3792
02:28:31,842 --> 02:28:33,611
PREDOMINANT IN WOMEN,

3793
02:28:33,611 --> 02:28:34,812
TEMPOROMANDIBULAR, IRRITABLE

3794
02:28:34,812 --> 02:28:36,914
BOWEL, THESE ARE ADDRESSED BY A

3795
02:28:36,914 --> 02:28:40,518
SET OF DIFFERENT TYPES OF

3796
02:28:40,518 --> 02:28:41,285
PROGRAMS, SOME BIOMARKER

3797
02:28:41,285 --> 02:28:44,121
PROGRAMS, SOME TRIALS OF

3798
02:28:44,121 --> 02:28:46,957
EFFECTIVENESS, SOME PRAGMATIC

3799
02:28:46,957 --> 02:28:47,191
TRIALS.

3800
02:28:47,191 --> 02:28:50,795
AND THE NEXT SLIDE TELLS US THAT

3801
02:28:50,795 --> 02:28:55,066
THIS WORK IS TIMELY IN THAT THE

3802
02:28:55,066 --> 02:28:58,869
WHITE HOUSE RECENTLY RELEASED AN

3803
02:28:58,869 --> 02:29:02,707
INITIATIVE ON WOMEN'S HEALTH,

3804
02:29:02,707 --> 02:29:03,774
AND TARGETED RESEARCH BEING

3805
02:29:03,774 --> 02:29:05,009
IMPROVED AND ENHANCED IN THE

3806
02:29:05,009 --> 02:29:06,644
AREA OF WOMEN'S HEALTH.

3807
02:29:06,644 --> 02:29:09,914
AND IF WE LOOK ACROSS THE

3808
02:29:09,914 --> 02:29:11,582
SPOTLIGHT THAT "HEAL" IS

3809
02:29:11,582 --> 02:29:14,085
CURRENTLY DOING TO ADDRESS THIS,

3810
02:29:14,085 --> 02:29:17,788
WE CAN SEE THE LIST THAT I GAVE

3811
02:29:17,788 --> 02:29:21,525
EARLIER AND HOW IT IS BEING

3812
02:29:21,525 --> 02:29:24,795
ADDRESSED, WHETHER BIOMARKER

3813
02:29:24,795 --> 02:29:26,764
PROGRAM, FOR EXAMPLE,

3814
02:29:26,764 --> 02:29:35,973
MECHANISTIC STUDIES FOR TRIJUST 

3815
02:29:35,973 --> 02:29:36,607
TRIGEMINAL NEURALGIA, SO ON

3816
02:29:36,607 --> 02:29:38,375
THROUGH THE LIST.

3817
02:29:38,375 --> 02:29:40,444
AN IMPORTANT AREA OF RESEARCH

3818
02:29:40,444 --> 02:29:42,413
NEEDS AND SOMETHING THAT "HEAL"

3819
02:29:42,413 --> 02:29:46,484
IS AND CONTINUES TO ADDRESS.

3820
02:29:46,484 --> 02:29:50,087
AND THE NEXT SLIDE LOOKS AT

3821
02:29:50,087 --> 02:29:51,889
ANOTHER ISSUE THAT "HEAL" IS

3822
02:29:51,889 --> 02:29:53,791
LOOKING AT, AND THIS IS THAT

3823
02:29:53,791 --> 02:29:59,597
CHRONIC PAIN  RARELY COMES BY

3824
02:29:59,597 --> 02:30:01,265
ITSELF IN AN INDIVIDUAL, OFTEN

3825
02:30:01,265 --> 02:30:02,700
ASSOCIATED WITH OTHER CHRONIC

3826
02:30:02,700 --> 02:30:08,372
ILLNESS, THIS GIVES A BURDEN OF

3827
02:30:08,372 --> 02:30:09,707
DISEASE, EXAMPLES WHERE CHRONIC

3828
02:30:09,707 --> 02:30:11,976
PAIN IS MORE LIKELY TO BE

3829
02:30:11,976 --> 02:30:13,444
ASSOCIATED OR HOW LIKELY IT IS

3830
02:30:13,444 --> 02:30:16,714
TO BE ASSOCIATE IT'S WITH A

3831
02:30:16,714 --> 02:30:18,249
NUMBER OF DIFFERENT POPULATION

3832
02:30:18,249 --> 02:30:19,884
LEVEL HIGH IMPACT CHRONIC

3833
02:30:19,884 --> 02:30:20,284
CONDITIONS.

3834
02:30:20,284 --> 02:30:22,520
AND THE NEXT SLIDE WILL SHOW YOU

3835
02:30:22,520 --> 02:30:24,021
THAT "HEAL" IS ADDRESSING SOME

3836
02:30:24,021 --> 02:30:26,891
OF THESE ISSUES OR HOW DO WE

3837
02:30:26,891 --> 02:30:29,293
TREAT PEOPLE WITH CHRONIC PAIN

3838
02:30:29,293 --> 02:30:30,361
WHO HAVE OTHER CHRONIC

3839
02:30:30,361 --> 02:30:33,664
CONDITIONS ASSOCIATED WITH THAT

3840
02:30:33,664 --> 02:30:34,865
PAIN.

3841
02:30:34,865 --> 02:30:36,634
SO THIS HIGHLIGHTS COMPLEXITY OF

3842
02:30:36,634 --> 02:30:39,336
NOT JUST DIFFERENCE IN PAIN

3843
02:30:39,336 --> 02:30:40,871
CONDITIONS BUT ALSO IN COMORBID

3844
02:30:40,871 --> 02:30:41,739
CONDITIONS.

3845
02:30:41,739 --> 02:30:51,282
SO WE HAVE A PROGRAM, TWO 

3846
02:30:51,282 --> 02:30:53,384
PROGRAMS, IMPOWR AND MIRQYLL TO

3847
02:30:53,384 --> 02:30:55,452
GIVE DELIVER PAIN CARE FOR

3848
02:30:55,452 --> 02:30:56,453
PEOPLE WITH SUBSTANCE USE

3849
02:30:56,453 --> 02:30:58,322
DISORDER AND/OR PEOPLE WHO HAVE

3850
02:30:58,322 --> 02:31:00,291
BEEN ON OPIOIDS FOR LONG TERM

3851
02:31:00,291 --> 02:31:04,228
AND ARE AT RISK FOR SUBSTANCE

3852
02:31:04,228 --> 02:31:05,095
USE DISORDER.

3853
02:31:05,095 --> 02:31:07,064
EXAMPLE, THESE ARE FAIRLY NEW

3854
02:31:07,064 --> 02:31:09,567
PROGRAMS, WHAT THEY HAVE ALREADY

3855
02:31:09,567 --> 02:31:11,669
DEVELOPED IS A RISK ASSESSMENT

3856
02:31:11,669 --> 02:31:14,638
TOOL FOR HOW DO WE START TO

3857
02:31:14,638 --> 02:31:18,309
DETECT THE PEOPLE MOST LIKELY,

3858
02:31:18,309 --> 02:31:24,682
IN LONG TERM OPIOIDS, GO ON TO

3859
02:31:24,682 --> 02:31:26,116
OPIOID USE DISORDER DISORDER BUT

3860
02:31:26,116 --> 02:31:27,218
NEED GOOD PAIN MANAGEMENT.

3861
02:31:27,218 --> 02:31:27,952
THOSE TWO PROGRAMS ARE

3862
02:31:27,952 --> 02:31:31,121
ADDRESSING THAT. 

3863
02:31:31,121 --> 02:31:33,757
WE HAVE AN EXTENSIVE PROGRAM ON

3864
02:31:33,757 --> 02:31:35,426
HEALTH EQUITIES.

3865
02:31:35,426 --> 02:31:40,631
THIS PROGRAM, THERE ARE 11 

3866
02:31:40,631 --> 02:31:43,734
STUDIES IN HERE, ALL CENTERED ON

3867
02:31:43,734 --> 02:31:47,872
THE CONCEPT THAT DIFFERENT

3868
02:31:47,872 --> 02:31:50,107
POPULATIONS NEED VERY TARGETED

3869
02:31:50,107 --> 02:31:53,344
PAIN MANAGEMENT STRATEGIES THAT

3870
02:31:53,344 --> 02:31:54,311
ARE CULTURALLY ACCEPTABLE AND

3871
02:31:54,311 --> 02:31:57,381
REALLY ADDRESS THE NEEDS OF

3872
02:31:57,381 --> 02:32:00,050
THOSE POPULATIONS IN CONCERT

3873
02:32:00,050 --> 02:32:03,754
WITH THE COMMUNITIES WHERE THEY

3874
02:32:03,754 --> 02:32:07,892
LIVE AND SO IT'S A REALLY HIGH

3875
02:32:07,892 --> 02:32:08,792
COMMUNITY ENGAGEMENT PROGRAM TO

3876
02:32:08,792 --> 02:32:10,394
REALLY GET THROUGH SOME OF THE

3877
02:32:10,394 --> 02:32:13,597
BARRIERS AND CHALLENGES THAT ARE

3878
02:32:13,597 --> 02:32:17,101
ASSOCIATED WITH POPULATIONS OF

3879
02:32:17,101 --> 02:32:18,002
HEALTH DISPARITIES.

3880
02:32:18,002 --> 02:32:20,371
THOSE PROGRAMS, MOST OF THESE

3881
02:32:20,371 --> 02:32:24,308
ARE ADDRESSING CHRONIC PAIN AND

3882
02:32:24,308 --> 02:32:25,542
EITHER MENTAL HEALTH CONDITIONS

3883
02:32:25,542 --> 02:32:26,710
OR OPIOID USE DISORDERS.

3884
02:32:26,710 --> 02:32:37,221
SO HERE YOU GET THAT SORT OF 

3885
02:32:38,289 --> 02:32:44,762
COMBINED ADDRESS  COMORBIDITIES.

3886
02:32:44,762 --> 02:32:48,165
AND THIS IS FOR TRIBAL NATION,

3887
02:32:48,165 --> 02:32:49,133
SUBSTANCE USE DISORDERS,

3888
02:32:49,133 --> 02:32:52,970
OVERDOSE, NORA VOLKOW TOLD US

3889
02:32:52,970 --> 02:32:54,471
DEATH IN NATIVE POPULATION IS

3890
02:32:54,471 --> 02:33:01,946
HIGHER BY TWO TIMES THAN IN THE

3891
02:33:01,946 --> 02:33:02,680
POPULATION, GENERAL POPULATION.

3892
02:33:02,680 --> 02:33:04,248
THIS WILL BE WORKING TO PROVIDE

3893
02:33:04,248 --> 02:33:06,317
RESOURCES TOKER RESEARCH IN THE

3894
02:33:06,317 --> 02:33:09,386
AREA OF PAIN, AND OVERDOSE

3895
02:33:09,386 --> 02:33:10,921
SUBSTANCE USE DISORDERS IN

3896
02:33:10,921 --> 02:33:12,790
DIFFERENT TRIBAL NATIONS AND

3897
02:33:12,790 --> 02:33:15,826
SORT OF BUILD A RESEARCH

3898
02:33:15,826 --> 02:33:17,361
INFRASTRUCTURE AND GIVE

3899
02:33:17,361 --> 02:33:18,896
RESOURCES TO RUN RESEARCH

3900
02:33:18,896 --> 02:33:20,965
PROGRAMS THAT THEY HELP TO

3901
02:33:20,965 --> 02:33:25,669
DEVELOP AND ARE REALLY TARGETED

3902
02:33:25,669 --> 02:33:26,470
TO THEIR PARTICULAR POPULATIONS

3903
02:33:26,470 --> 02:33:33,811
AND COMMUNITIES.

3904
02:33:33,811 --> 02:33:34,778
NEXT SLIDE.

3905
02:33:34,778 --> 02:33:39,049
TO GIVE YOU AN IDEA OF OUR

3906
02:33:39,049 --> 02:33:39,950
"HEAL" EFFECTIVENESS,

3907
02:33:39,950 --> 02:33:40,684
COMPARATIVE EFFECTIVENESS

3908
02:33:40,684 --> 02:33:43,420
STUDIES, WHERE WE'VE MADE

3909
02:33:43,420 --> 02:33:47,257
PROGRESS IN SOME LARGE CLINICAL

3910
02:33:47,257 --> 02:33:49,760
TRIALS, ACROSS THE SET OF PAIN

3911
02:33:49,760 --> 02:33:52,596
CONDITIONS, AND WHERE THEY ARE.

3912
02:33:52,596 --> 02:33:54,031
SO I'M NOT GOING THROUGH THEM

3913
02:33:54,031 --> 02:33:56,667
SPECIFICALLY BUT IT'S A RANGE OF

3914
02:33:56,667 --> 02:33:59,636
PAIN CONDITIONS BEING ADDRESSED

3915
02:33:59,636 --> 02:34:02,673
BY SPECIFIC INTERVENTIONS FOR

3916
02:34:02,673 --> 02:34:05,609
ACUTE PAIN, FOR PAIN THAT

3917
02:34:05,609 --> 02:34:07,811
MEDICATION AND SELF-MANAGEMENT

3918
02:34:07,811 --> 02:34:09,013
ASSISTED IN RURAL POPULATIONS,

3919
02:34:09,013 --> 02:34:11,315
FOR THOSE WITH CHRONIC PAIN AND

3920
02:34:11,315 --> 02:34:14,018
OUD IN A DIFFERENT POPULATION,

3921
02:34:14,018 --> 02:34:17,254
AND STAR COLOR TELLS YOU THAT

3922
02:34:17,254 --> 02:34:22,393
THE TRIAL IS COMPLETED AND BEING

3923
02:34:22,393 --> 02:34:24,661
PUBLISHED, AND THE SILVER STAR

3924
02:34:24,661 --> 02:34:27,231
ARE THOSE TRIALS THAT ARE

3925
02:34:27,231 --> 02:34:28,065
ACTUALLY COMPLETED RECRUITMENT

3926
02:34:28,065 --> 02:34:29,867
AND NEAR READY TO CLOSE OUT

3927
02:34:29,867 --> 02:34:31,268
THEIR TRIALS.

3928
02:34:31,268 --> 02:34:34,438
AND WE HAVE BRONZE AND BLUE STAR

3929
02:34:34,438 --> 02:34:38,475
AWARDEES WHO ARE 80% OR 50%

3930
02:34:38,475 --> 02:34:41,779
RECRUITED AND SO TO GIVE YOU AN

3931
02:34:41,779 --> 02:34:43,113
IDEA OF PROGRESS EFFECTIVENESS

3932
02:34:43,113 --> 02:34:49,119
NETWORK HAS MADE.

3933
02:34:49,119 --> 02:34:50,287
THE NEXT SLIDE.

3934
02:34:50,287 --> 02:34:51,588
THERE ARE TWO -- THIS IS THE

3935
02:34:51,588 --> 02:34:55,025
EARLY PHASE SO THIS IS THE PHASE

3936
02:34:55,025 --> 02:34:58,395
2 TRIAL NETWORK HAS RECRUITED

3937
02:34:58,395 --> 02:35:01,932
ENTIRELY FOR THEIR FIRST TRIAL

3938
02:35:01,932 --> 02:35:11,208
WHICH IS  TESTING A NOVEL CCR 2

3939
02:35:11,208 --> 02:35:12,876
AGONIST, THEY WILL GET

3940
02:35:12,876 --> 02:35:18,348
INTERESTING RESULTS FROM THERE. 

3941
02:35:18,348 --> 02:35:22,486
AND THE LARGE PROGRAM TO -- FOR

3942
02:35:22,486 --> 02:35:23,187
PAIN MANAGEMENT, SELF-MANAGEMENT

3943
02:35:23,187 --> 02:35:27,758
STRATEGIES AND WEANING OFF OF

3944
02:35:27,758 --> 02:35:29,193
OPIOIDS FOR THOSE UNDERGOING

3945
02:35:29,193 --> 02:35:31,595
HEMODIALYSIS IS COMPLETE.

3946
02:35:31,595 --> 02:35:33,464
DATA ANALYSIS ONGOING, HOPEFULLY

3947
02:35:33,464 --> 02:35:37,835
PUBLICATIONS WILL BE OUT SOON.

3948
02:35:37,835 --> 02:35:40,003
NEXT SLIDE.

3949
02:35:40,003 --> 02:35:42,639
THIS ONE GIVES YOU A COUPLE

3950
02:35:42,639 --> 02:35:44,274
THINGS HERE THAT HELENE WENT

3951
02:35:44,274 --> 02:35:46,343
INTO IN GREAT DETAIL.

3952
02:35:46,343 --> 02:35:48,645
I'LL GO QUICKLY.

3953
02:35:48,645 --> 02:35:52,816
WE WERE ASKED ABOUT WEARABLE

3954
02:35:52,816 --> 02:35:56,753
DEVICES TO MEASURE OUTPUTS OR AS

3955
02:35:56,753 --> 02:35:57,621
BIOMARKERS FOR PAIN.

3956
02:35:57,621 --> 02:35:58,822
THERE'S A NEW PROGRAM, WE EXPECT

3957
02:35:58,822 --> 02:36:01,925
TO FUND SOME OF THESE PROGRAMS

3958
02:36:01,925 --> 02:36:04,428
IN 2024, AND THESE CAN BE

3959
02:36:04,428 --> 02:36:08,132
DEVICES THAT CAN HELP DEVELOP A

3960
02:36:08,132 --> 02:36:10,667
BIOMARKER SIGNATURE OF PAIN,

3961
02:36:10,667 --> 02:36:12,169
PAIN PROGRESSION, MONITORING TO

3962
02:36:12,169 --> 02:36:14,705
RESPOND, MONITORING RESPONSES TO

3963
02:36:14,705 --> 02:36:17,674
TREATMENTS, AND ALSO FOR

3964
02:36:17,674 --> 02:36:19,042
OUTCOMES ASSESSMENT FOR PAIN.

3965
02:36:19,042 --> 02:36:23,981
AND THEN WE HAVE A LARGE PROGRAM

3966
02:36:23,981 --> 02:36:25,749
ON BIOMARKERS THAT ARE

3967
02:36:25,749 --> 02:36:26,583
PROGNOSTIC FOR DISEASE

3968
02:36:26,583 --> 02:36:28,919
PROGRESSION ACROSS A NUMBER OF

3969
02:36:28,919 --> 02:36:29,753
PAIN CONDITIONS.

3970
02:36:29,753 --> 02:36:31,889
AND ALSO SOME THAT ARE BEING

3971
02:36:31,889 --> 02:36:34,291
DEVELOPED FOR CLINICAL TRIAL

3972
02:36:34,291 --> 02:36:36,927
WORK WHERE WE CAN MONITOR HOW

3973
02:36:36,927 --> 02:36:40,397
WELL A PARTICULAR DRUG OR

3974
02:36:40,397 --> 02:36:42,733
THERAPY IS -- RESPONSE OF THAT

3975
02:36:42,733 --> 02:36:44,601
PARTICULAR DRUG OR THERAPY TO

3976
02:36:44,601 --> 02:36:47,304
HELP OUR CLINICAL TRIALS.

3977
02:36:47,304 --> 02:36:50,374
HELENE TALKED ABOUT BIOMARKER --

3978
02:36:50,374 --> 02:36:52,209
MYOFASCIAL PAIN PROGRAM, AND

3979
02:36:52,209 --> 02:36:53,010
THEN MENTIONED BACPAC.

3980
02:36:53,010 --> 02:36:55,412
BACPAC IS DOING A TRIAL, ALL

3981
02:36:55,412 --> 02:36:56,847
ABOUT BIOMARKERS.

3982
02:36:56,847 --> 02:37:01,652
AND ALL ABOUT HOW WE CAN USE

3983
02:37:01,652 --> 02:37:02,419
VERY DEEP PHENOTYPIC

3984
02:37:02,419 --> 02:37:04,688
CHARACTERISTICS OF PATIENTS IN A

3985
02:37:04,688 --> 02:37:06,690
CLINICAL TRIAL TO FIGURE OUT

3986
02:37:06,690 --> 02:37:08,659
WHICH -- IS A SMART TRIAL DESIGN

3987
02:37:08,659 --> 02:37:13,931
WHERE THEY SWITCH AROUND THE

3988
02:37:13,931 --> 02:37:14,464
INTERVENTIONS, WHICH

3989
02:37:14,464 --> 02:37:16,667
INTERVENTIONS COUPLED WITH DEEP

3990
02:37:16,667 --> 02:37:23,006
DATASET ON THE PATIENTS, WHICH

3991
02:37:23,006 --> 02:37:25,175
ARE MOST LIKELY TO WORK FOR

3992
02:37:25,175 --> 02:37:26,276
SOMEONE WITH PARTICULAR

3993
02:37:26,276 --> 02:37:27,277
PHENOTYPIC CHARACTERISTICS IN A

3994
02:37:27,277 --> 02:37:29,346
TRIAL SETTING AND THEN IN A

3995
02:37:29,346 --> 02:37:30,247
CLINICAL SETTING.

3996
02:37:30,247 --> 02:37:33,183
SO THIS IS COMPLETED.

3997
02:37:33,183 --> 02:37:34,618
DATA ANALYSIS HAS STARTED.

3998
02:37:34,618 --> 02:37:37,754
AND WE EXPECT THIS ONE TO BE

3999
02:37:37,754 --> 02:37:40,724
REALLY HELPFUL FOR BACK PAIN,

4000
02:37:40,724 --> 02:37:41,792
THE MOST PREVALENT CONDITION OF

4001
02:37:41,792 --> 02:37:50,167
PAIN IN THE U.S.

4002
02:37:50,167 --> 02:37:51,034
NEXT SLIDE.

4003
02:37:51,034 --> 02:37:52,469
WE RECOGNIZE ALL THIS RESEARCH

4004
02:37:52,469 --> 02:37:54,905
AND RESEARCH SUPPORT IS

4005
02:37:54,905 --> 02:37:57,407
AVAILABLE AND EXPANDING AS OUR

4006
02:37:57,407 --> 02:37:59,376
RESEARCH WORKFORCE IN PAIN

4007
02:37:59,376 --> 02:38:01,111
ESPECIALLY IN CLINICAL PAIN

4008
02:38:01,111 --> 02:38:03,847
RESEARCH IS BEGINNING TO

4009
02:38:03,847 --> 02:38:04,081
DWINDLE.

4010
02:38:04,081 --> 02:38:07,351
AND SO HEAL HAS PROMOTED A

4011
02:38:07,351 --> 02:38:11,855
NUMBER OF DIFFERENT PROGRAMS TO

4012
02:38:11,855 --> 02:38:14,591
INCREASE TRAINING FOR PEOPLE IN

4013
02:38:14,591 --> 02:38:15,792
DISPARATE POPULATIONS, THROUGH

4014
02:38:15,792 --> 02:38:19,396
DIVERSITY SUPPLEMENTS, WE HAVE A

4015
02:38:19,396 --> 02:38:21,498
K12 NATIONAL NETWORK MATCHING UP

4016
02:38:21,498 --> 02:38:22,933
MENTORS ACROSS THE COUNTRY LIKE

4017
02:38:22,933 --> 02:38:24,668
REALLY GOOD MENTORS WITH REALLY

4018
02:38:24,668 --> 02:38:26,536
GOOD TRACK RECORDS, WITH

4019
02:38:26,536 --> 02:38:28,805
PROMISING YOUNG SCHOLARS WHO

4020
02:38:28,805 --> 02:38:30,307
NEED BETTER TRAINING.

4021
02:38:30,307 --> 02:38:35,612
THE PURPOSE NETWORK IS A DIGITAL

4022
02:38:35,612 --> 02:38:37,247
PLATFORM WHERE INVESTIGATORS AND

4023
02:38:37,247 --> 02:38:39,516
TRAINEES AND PEOPLE WITH LIVED

4024
02:38:39,516 --> 02:38:41,618
EXPERIENCE CAN COME TOGETHER AND

4025
02:38:41,618 --> 02:38:43,587
SHARE INFORMATION, SHARE

4026
02:38:43,587 --> 02:38:45,022
CONVERSATIONS, WRITE GRANTS

4027
02:38:45,022 --> 02:38:45,856
TOGETHER, THROUGH THIS

4028
02:38:45,856 --> 02:38:47,524
NETWORKING PLATFORM.

4029
02:38:47,524 --> 02:38:49,192
IT HAS OVER 2,000 MEMBERS

4030
02:38:49,192 --> 02:38:53,897
ALREADY FROM THE PAIN COMMUNITY.

4031
02:38:53,897 --> 02:38:57,601
THE K99/R00 IS A PROGRAM TO SORT

4032
02:38:57,601 --> 02:39:00,237
OF ACCELERATE TRANSITION FROM

4033
02:39:00,237 --> 02:39:03,073
POSTDOC TO INDEPENDENT RESEARCH.

4034
02:39:03,073 --> 02:39:07,811
AND THEN WE HAVE A SMALL SET OF

4035
02:39:07,811 --> 02:39:10,314
ADMINISTRATIVE SUPPLEMENTS FOR

4036
02:39:10,314 --> 02:39:12,616
PEOPLE WHO ARE AT EARLY CAREER

4037
02:39:12,616 --> 02:39:14,584
STAGES IN PAIN RESEARCH TO

4038
02:39:14,584 --> 02:39:16,453
SUPPORT THEM OR THEIR RESEARCH.

4039
02:39:16,453 --> 02:39:22,592
THE NEW PROGRAM COMING OUT IS A

4040
02:39:22,592 --> 02:39:23,927
T90/R90, INSTITUTIONAL TRAINING

4041
02:39:23,927 --> 02:39:24,227
GRANTS.

4042
02:39:24,227 --> 02:39:25,962
THE WHOLE TRAINING PROGRAM WILL

4043
02:39:25,962 --> 02:39:27,731
BE A COHORT SO SEVERAL PEOPLE

4044
02:39:27,731 --> 02:39:29,800
COMING IN ONE YEAR TRAIN

4045
02:39:29,800 --> 02:39:35,172
TOGETHER, AND THEY WILL ACCEPT

4046
02:39:35,172 --> 02:39:36,606
FOREIGN APPLICANTS WITHIN THE

4047
02:39:36,606 --> 02:39:38,542
PROGRAM, NOT THE INSTITUTION BUT

4048
02:39:38,542 --> 02:39:40,510
TRAINEES AS WELL AS U.S.

4049
02:39:40,510 --> 02:39:42,079
CITIZENS OR GREEN CARDHOLDERS.

4050
02:39:42,079 --> 02:39:48,185
SO THAT'S UNIQUE.

4051
02:39:48,185 --> 02:39:51,788
THE NEXT SLIDE TELLS US ABOUT

4052
02:39:51,788 --> 02:39:54,091
THE HEAL DATA ECOSYSTEM AND THIS

4053
02:39:54,091 --> 02:39:57,794
IS BEING SET UP FOR REALLY TO

4054
02:39:57,794 --> 02:39:58,528
MAXIMIZE DATA HARMONIZATION AND

4055
02:39:58,528 --> 02:40:00,330
SHARING ACROSS THE HEAL

4056
02:40:00,330 --> 02:40:02,065
INITIATIVE, AND HAS REALLY

4057
02:40:02,065 --> 02:40:04,601
LONG-TERM BENEFITS FOR PEOPLE

4058
02:40:04,601 --> 02:40:06,370
BEING ACCESS -- GETTING ACCESS

4059
02:40:06,370 --> 02:40:07,537
TO THE DATA.

4060
02:40:07,537 --> 02:40:12,075
A HUGE AMOUNT OF DATA COLLECTED 

4061
02:40:12,075 --> 02:40:15,312
BY "HEAL."

4062
02:40:15,312 --> 02:40:19,449
FINALLY IN THE LAST SLIDE, THIS

4063
02:40:19,449 --> 02:40:22,386
IS MORE OF AN FYI, ALL THIS

4064
02:40:22,386 --> 02:40:24,488
INFORMATION IS IN YOUR PACKET,

4065
02:40:24,488 --> 02:40:26,790
TO GIVE YOU A SENSE OR REMINDER

4066
02:40:26,790 --> 02:40:29,726
IF YOU WILL OF THE "HEAL"

4067
02:40:29,726 --> 02:40:33,797
PROGRAMS THAT ARE BEING

4068
02:40:33,797 --> 02:40:38,068
REISSUED, IN 2025 OR 2026, AND

4069
02:40:38,068 --> 02:40:41,104
THEY INCLUDE A PROGRAM TO

4070
02:40:41,104 --> 02:40:43,740
PROMOTE CARE CENTERED IN PRIMARY

4071
02:40:43,740 --> 02:40:48,011
CARE FOR PAIN MANAGEMENT THAT

4072
02:40:48,011 --> 02:40:50,647
INCLUDES CONNECTIONS OR

4073
02:40:50,647 --> 02:40:52,516
INTEGRATION WITH SPECIALTY CARE,

4074
02:40:52,516 --> 02:40:54,017
THIS ONE WAS APPROVED YEAR

4075
02:40:54,017 --> 02:40:57,954
BEFORE LAST BY THE COUNCIL.

4076
02:40:57,954 --> 02:40:59,623
THE PRISM, PRAGMATIC STUDIES

4077
02:40:59,623 --> 02:41:04,828
THAT WE DO TO IMPLEMENT CARE IS

4078
02:41:04,828 --> 02:41:06,062
WORKING, THEY WON'T BE DOING

4079
02:41:06,062 --> 02:41:09,232
THEIR OWN TRIALS BUT SETTING UP

4080
02:41:09,232 --> 02:41:12,936
A REALLY -- USING A COORDINATING

4081
02:41:12,936 --> 02:41:15,038
CENTER TO SUPPORT ALL SORT OF

4082
02:41:15,038 --> 02:41:19,609
TRIALS THAT ARE TRYING TO

4083
02:41:19,609 --> 02:41:21,278
IMPLEMENT AND HELP GOOD BETTER

4084
02:41:21,278 --> 02:41:25,215
HEALTH CARE INTO HEALTH CARE

4085
02:41:25,215 --> 02:41:25,749
SYSTEMS.

4086
02:41:25,749 --> 02:41:26,349
THE BACPAC CONSORTIUM YOU'VE

4087
02:41:26,349 --> 02:41:27,617
HEARD ABOUT THAT.

4088
02:41:27,617 --> 02:41:30,353
IS COMING UP FOR REISSUE NEXT

4089
02:41:30,353 --> 02:41:34,825
YEAR TO REALLY LEVERAGE ALL THE

4090
02:41:34,825 --> 02:41:35,725
INFORMATION AND THE

4091
02:41:35,725 --> 02:41:36,927
INFRASTRUCTURE, DATA ALGORITHMS

4092
02:41:36,927 --> 02:41:39,663
THAT BACPAC HAS ALREADY

4093
02:41:39,663 --> 02:41:40,931
DEVELOPED.

4094
02:41:40,931 --> 02:41:43,366
WE WILL CONTINUE TO OFFER SMALL

4095
02:41:43,366 --> 02:41:46,203
ADMINISTRATIVE SUPPLEMENTS FOR

4096
02:41:46,203 --> 02:41:47,270
CAREER ENHANCEMENT AND CLINICAL

4097
02:41:47,270 --> 02:41:49,406
RESEARCH ON PAIN.

4098
02:41:49,406 --> 02:41:50,373
MENTIONED DATA ECOSYSTEM.

4099
02:41:50,373 --> 02:41:52,943
AND THERE ARE TWO NEW CONCEPTS,

4100
02:41:52,943 --> 02:41:56,279
ONE WHICH WILL BE SUPPORTED BY

4101
02:41:56,279 --> 02:42:01,418
NCCIH, AND THIS IS TO RUN 

4102
02:42:01,418 --> 02:42:03,053
CLINICAL TRIALS FOR

4103
02:42:03,053 --> 02:42:05,689
EFFECTIVENESS IN THE NIH DoD

4104
02:42:05,689 --> 02:42:06,656
V.A. PAIN MANAGEMENT LABORATORY

4105
02:42:06,656 --> 02:42:09,726
WHICH I DIDN'T MENTION HERE, THE

4106
02:42:09,726 --> 02:42:10,594
COLLABORATORY IS SOMETHING

4107
02:42:10,594 --> 02:42:11,962
THAT'S BEEN AROUND FOR A NUMBER

4108
02:42:11,962 --> 02:42:14,364
OF YEARS AND TRYING TO EMBED

4109
02:42:14,364 --> 02:42:17,634
BETTER PAIN CARE INTO THE V.A.

4110
02:42:17,634 --> 02:42:19,603
AND DoD SYSTEM IN PARTNERSHIP

4111
02:42:19,603 --> 02:42:20,604
WITH THE NIH.

4112
02:42:20,604 --> 02:42:25,208
AND THEN WE HAVE A CAREER

4113
02:42:25,208 --> 02:42:28,078
DEVELOPMENT CONCEPT FOR K23 AND

4114
02:42:28,078 --> 02:42:29,412
K08 AWARDS FOR CLINICAL

4115
02:42:29,412 --> 02:42:31,915
RESEARCHERS, IN THE PAIN REALM,

4116
02:42:31,915 --> 02:42:34,784
AND THAT'S BEEN BASED ON A

4117
02:42:34,784 --> 02:42:36,753
REALLY STRONG PORTFOLIO ANALYSIS

4118
02:42:36,753 --> 02:42:40,257
OF HOW SUCCESSFUL THESE TYPES OF

4119
02:42:40,257 --> 02:42:42,025
MENTORING PROGRAMS HAVE BEEN IN

4120
02:42:42,025 --> 02:42:43,426
THE CLINICAL PAIN RESEARCH ARENA

4121
02:42:43,426 --> 02:42:45,428
IN THE PAST.

4122
02:42:45,428 --> 02:42:47,597
AND MOVING THAT FORWARD.

4123
02:42:47,597 --> 02:42:50,767
SO, I WILL SAY THANK YOU VERY

4124
02:42:50,767 --> 02:42:52,936
MUCH AND I CAN TAKE SOME

4125
02:42:52,936 --> 02:42:53,803
QUESTIONS I THINK.

4126
02:42:53,803 --> 02:42:57,541
MICHAEL, DID YOU HAVE ONE MORE

4127
02:42:57,541 --> 02:42:59,175
CONCEPT -- OR REISSUE THAT YOU

4128
02:42:59,175 --> 02:43:00,010
WANTED TO MENTION?

4129
02:43:00,010 --> 02:43:01,912
>> I PUT THEM ON THE SLIDE

4130
02:43:01,912 --> 02:43:02,412
ALREADY.

4131
02:43:02,412 --> 02:43:03,880
>> THEY WERE UP.

4132
02:43:03,880 --> 02:43:04,247
OKAY.

4133
02:43:04,247 --> 02:43:06,283
>> YES.

4134
02:43:06,283 --> 02:43:09,920
 

4135
02:43:09,920 --> 02:43:12,088
>> THANK YOU BOTH.

4136
02:43:12,088 --> 02:43:13,623
INCREDIBLY INFORMATIVE AND VERY

4137
02:43:13,623 --> 02:43:13,890
EXCITING.

4138
02:43:13,890 --> 02:43:15,125
I HEARD WALTER SAY YOU CAN'T

4139
02:43:15,125 --> 02:43:19,629
JUST GO TO CAPITOL HILL BUT

4140
02:43:19,629 --> 02:43:20,864
CAPITOL HILL SHOULD INVITE YOU

4141
02:43:20,864 --> 02:43:22,699
EVERY SIX MONTHS TO HEAR ABOUT

4142
02:43:22,699 --> 02:43:26,202
THIS, IMPORTANT TO HEAR WHAT NIH

4143
02:43:26,202 --> 02:43:27,070
DOES.

4144
02:43:27,070 --> 02:43:29,606
THE ADRD WORLD, THE BOOST LED TO

4145
02:43:29,606 --> 02:43:32,242
A MASSIVE NUMBER OF PEOPLE WHO

4146
02:43:32,242 --> 02:43:33,743
SHIFTED INTO ALZHEIMER'S, NEW

4147
02:43:33,743 --> 02:43:34,511
INVESTIGATORS GOING INTO

4148
02:43:34,511 --> 02:43:35,345
ALZHEIMER'S, I'M SENSING YOU

4149
02:43:35,345 --> 02:43:37,814
FEEL IN THE FIVE YEARS OF "HEAL"

4150
02:43:37,814 --> 02:43:44,854
WE STILL  HAVEN'T BEEN ABLE TO 

4151
02:43:44,854 --> 02:43:47,557
INJECT INTO YOUNGER

4152
02:43:47,557 --> 02:43:49,192
INVESTIGATORS, WHY DO YOU THINK

4153
02:43:49,192 --> 02:43:52,829
THAT IS THE CASE IF IT IS.

4154
02:43:52,829 --> 02:43:53,697
>> WE SURVEYED
PROFESSIONAL

4155
02:43:53,697 --> 02:43:56,299
ORGANIZATIONS TO ASK THAT EXACT

4156
02:43:56,299 --> 02:43:56,566
QUESTION.

4157
02:43:56,566 --> 02:43:57,534
AND IT'S A COMBINATION OF

4158
02:43:57,534 --> 02:43:57,767
THINGS.

4159
02:43:57,767 --> 02:44:00,270
IT'S A LACK OF SUPPORT FOR THEIR

4160
02:44:00,270 --> 02:44:00,537
RESEARCH.

4161
02:44:00,537 --> 02:44:04,874
SO WHAT WE'RE DOING IS REALLY

4162
02:44:04,874 --> 02:44:08,378
TRYING TO ADDRESS THAT CONCERN.

4163
02:44:08,378 --> 02:44:12,515
ALSO, THE ISSUE OF THESE ARE THE

4164
02:44:12,515 --> 02:44:14,184
CLINICAL RESEARCHERS WE TRYING

4165
02:44:14,184 --> 02:44:15,151
TO ATTRACT, PRACTITIONERS,

4166
02:44:15,151 --> 02:44:17,020
USUALLY IN THEIR ACADEMIC

4167
02:44:17,020 --> 02:44:18,655
SITUATIONS THERE IS PRESSURE TO

4168
02:44:18,655 --> 02:44:21,625
STAY IN THE CLINIC AND SO IT'S

4169
02:44:21,625 --> 02:44:23,693
DIFFICULT TO FIND TIME TO

4170
02:44:23,693 --> 02:44:25,228
ACTUALLY DO RESEARCH.

4171
02:44:25,228 --> 02:44:26,830
THE OTHER CHALLENGE IS THAT PAIN

4172
02:44:26,830 --> 02:44:31,267
RESEARCH NOW NEEDS TO BE REALLY

4173
02:44:31,267 --> 02:44:32,002
MULTI-DISCIPLINARY, SO IT'S HARD

4174
02:44:32,002 --> 02:44:34,671
TO FIND A PROGRAM WHERE THEY ARE

4175
02:44:34,671 --> 02:44:35,939
EXPAND A LITTLE BIT WHERE

4176
02:44:35,939 --> 02:44:38,375
PRIMARY INTERESTS MAY BE.

4177
02:44:38,375 --> 02:44:40,276
THAT'S ONE OF THE THING T90/R90

4178
02:44:40,276 --> 02:44:42,345
PROGRAM WILL DO IS REQUIRED

4179
02:44:42,345 --> 02:44:45,315
WITHIN THAT PROGRAM THAT THE

4180
02:44:45,315 --> 02:44:47,050
TRAINEES, THE INSTITUTION CAN

4181
02:44:47,050 --> 02:44:48,585
OFFER TRAINEES SORTS OF WHAT YOU

4182
02:44:48,585 --> 02:44:50,153
THINK OF AS STANDARD PAIN

4183
02:44:50,153 --> 02:44:52,088
RESEARCH TRAINING, WHICH MIGHT

4184
02:44:52,088 --> 02:44:54,724
BE EFFECTIVENESS RESEARCH OR

4185
02:44:54,724 --> 02:44:55,158
WHATEVER.

4186
02:44:55,158 --> 02:44:57,127
BUT ALSO TO TIE THEM INTO A

4187
02:44:57,127 --> 02:44:58,128
DISCIPLINE THAT'S IMPORTANT FOR

4188
02:44:58,128 --> 02:44:58,328
PAIN.

4189
02:44:58,328 --> 02:45:03,733
IT COULD BE DATA MANAGEMENT. 

4190
02:45:03,733 --> 02:45:05,468
IT COULD BE OUD MANAGEMENT.

4191
02:45:05,468 --> 02:45:07,737
WE'RE TRYING TO SORT OF TARGET

4192
02:45:07,737 --> 02:45:10,040
PLACES WHERE THE SURVEY TOLD US

4193
02:45:10,040 --> 02:45:12,342
THAT THE CHALLENGES WERE TO

4194
02:45:12,342 --> 02:45:16,379
BRING NEW PEOPLE INTO THE

4195
02:45:16,379 --> 02:45:17,380
RESEARCH WORKFORCE.

4196
02:45:17,380 --> 02:45:20,750
>> I WOULD ADD WE'RE ALSO

4197
02:45:20,750 --> 02:45:21,951
DEVELOPING PROGRAMS THAT WILL

4198
02:45:21,951 --> 02:45:23,053
TRAIN THE RESEARCHERS IN THE

4199
02:45:23,053 --> 02:45:25,455
TYPE OF RESEARCH THAT WE NEED IN

4200
02:45:25,455 --> 02:45:25,655
PAIN.

4201
02:45:25,655 --> 02:45:27,323
IN THE PAST THERE'S REALLY BEEN

4202
02:45:27,323 --> 02:45:29,392
A DISCONNECT BETWEEN THOSE DOING

4203
02:45:29,392 --> 02:45:31,594
THE BASIC BIOLOGY AND STUDY OF

4204
02:45:31,594 --> 02:45:33,963
PAIN AND DIFFERENT PROTEINS AND

4205
02:45:33,963 --> 02:45:35,532
CELL TYPES, ET CETERA, AND THEN

4206
02:45:35,532 --> 02:45:37,033
WHEN THE COMPANIES WENT TO LOOK

4207
02:45:37,033 --> 02:45:37,934
AT THESE TARGETS TO SEE WHETHER

4208
02:45:37,934 --> 02:45:40,904
OR NOT THEY COULD USE THEM, IF

4209
02:45:40,904 --> 02:45:42,939
THEY WERE DRUGGABLE OR IF THEY

4210
02:45:42,939 --> 02:45:45,575
COULD BE USED AS STIMULATOR,

4211
02:45:45,575 --> 02:45:47,343
THERE WAS A DISCONNECT FROM THE

4212
02:45:47,343 --> 02:45:49,512
TYPE OF DATA BEING COMMUNICATED,

4213
02:45:49,512 --> 02:45:51,614
TYPE OF EXPERIMENTS BEING DONE

4214
02:45:51,614 --> 02:45:52,682
TO VALIDATE THESE TARGETS AND

4215
02:45:52,682 --> 02:45:54,084
WHAT WAS NEEDED BY THE COMPANY.

4216
02:45:54,084 --> 02:45:56,853
THE WORK HAD TO BE DONE ALL OVER

4217
02:45:56,853 --> 02:45:57,087
AGAIN.

4218
02:45:57,087 --> 02:45:59,255
SO WE'RE TRYING TO DESIGN THE

4219
02:45:59,255 --> 02:46:01,991
PROGRAMS TO FOCUS THE TYPE OF

4220
02:46:01,991 --> 02:46:04,060
RESEARCH AND THEN THOSE FUNDING

4221
02:46:04,060 --> 02:46:04,794
ANNOUNCEMENTS ARE ENCOURAGING

4222
02:46:04,794 --> 02:46:06,062
PEOPLE TO COME IN THE FIELD AND

4223
02:46:06,062 --> 02:46:09,265
DO THAT KIND OF WORK, OR

4224
02:46:09,265 --> 02:46:11,601
GRADUATE STUDENT WHO WILL BE

4225
02:46:11,601 --> 02:46:14,671
FOCUSED NOW WHEN THEY GET THEIR

4226
02:46:14,671 --> 02:46:15,939
POSTDOC AND FACULTY POSITION

4227
02:46:15,939 --> 02:46:16,873
FOCUSED ON THERAPEUTICS

4228
02:46:16,873 --> 02:46:18,508
DEVELOPMENT AND NOT JUST

4229
02:46:18,508 --> 02:46:20,243
UNDERSTANDING THE BASIC BIOLOGY

4230
02:46:20,243 --> 02:46:22,545
BUT THE BASIC BIOLOGY FOR

4231
02:46:22,545 --> 02:46:23,413
THERAPEUTICS DEVELOPMENT.

4232
02:46:23,413 --> 02:46:25,081
I'VE HEARD ROB SAY THAT BEFORE

4233
02:46:25,081 --> 02:46:26,616
IN THE PAST, YOU'VE SEEN

4234
02:46:26,616 --> 02:46:27,584
STUDENTS DOING THAT.

4235
02:46:27,584 --> 02:46:28,118
GO AHEAD.

4236
02:46:28,118 --> 02:46:33,089
I SEE YOUR HAND IS UP.

4237
02:46:33,089 --> 02:46:34,924
>> YEAH, ABSOLUTELY.

4238
02:46:34,924 --> 02:46:38,328
THE PAIN FIELD SPECIFICALLY

4239
02:46:38,328 --> 02:46:39,295
SUFFERED FROM HISTORICAL

4240
02:46:39,295 --> 02:46:39,963
UNDERFUNDING REALLY.

4241
02:46:39,963 --> 02:46:45,435
AND IT WAS NOT SEEN AS A VIABLE

4242
02:46:45,435 --> 02:46:45,702
AREA.

4243
02:46:45,702 --> 02:46:51,875
EVEN FOR JUST BIOMEDICAL Ph.D.

4244
02:46:51,875 --> 02:47:02,285
STUDENTS DIDN'T SEEM LIKE AN

4245
02:47:02,285 --> 02:47:03,787
AREA THAT WAS ROBUSTLY

4246
02:47:03,787 --> 02:47:04,154
CONSIDERED.

4247
02:47:04,154 --> 02:47:06,756
WE'VE SEEN THIS GROW A LITTLE

4248
02:47:06,756 --> 02:47:07,190
BIT.

4249
02:47:07,190 --> 02:47:08,825
IT'S GOING TO LET PEOPLE KNOW

4250
02:47:08,825 --> 02:47:11,561
IT'S NOT JUST A FLASH IN THE

4251
02:47:11,561 --> 02:47:11,728
PAN.

4252
02:47:11,728 --> 02:47:18,802
NIH IS INVESTING IN THE FUTURE

4253
02:47:18,802 --> 02:47:19,435
OF THIS.

4254
02:47:19,435 --> 02:47:25,375
I HEAR PEOPLE TALKING ABOUT

4255
02:47:25,375 --> 02:47:26,242
"HEAL" TRAINING PROGRAMMING

4256
02:47:26,242 --> 02:47:28,211
IMPACTING ENTHUSIASM, A VIABLE

4257
02:47:28,211 --> 02:47:31,681
AREA FOR SCIENTISTS, SO BRAVO.

4258
02:47:31,681 --> 02:47:32,849
>> RIGHT.

4259
02:47:32,849 --> 02:47:36,519
I ALSO SAY, AND I THINK MAYBE

4260
02:47:36,519 --> 02:47:38,488
THE PRACTITIONERS, FRANCES AND

4261
02:47:38,488 --> 02:47:39,689
PEOPLE RUNNING NEUROLOGY

4262
02:47:39,689 --> 02:47:42,392
DEPARTMENTS, KNOW WE'RE SWIMMING

4263
02:47:42,392 --> 02:47:43,726
UPSTREAM IN TERMS OF CLINICAL

4264
02:47:43,726 --> 02:47:46,696
CARE FOR PEOPLE WHO HAVE PAIN,

4265
02:47:46,696 --> 02:47:48,998
MOST OF THE REIMBURSEMENT HAS

4266
02:47:48,998 --> 02:47:52,702
MOVED INTO PROCEDURAL PAIN

4267
02:47:52,702 --> 02:47:52,936
CENTERS.

4268
02:47:52,936 --> 02:47:54,671
AND SO NEUROLOGY IS FOR INSTANCE

4269
02:47:54,671 --> 02:47:57,841
PRETTY WEAK ON THIS SIDE, ON THE

4270
02:47:57,841 --> 02:48:02,645
CLINICAL SIDE OF PAIN, AND THE

4271
02:48:02,645 --> 02:48:05,081
REIMBURSEMENT FOR TAKING CARE OF

4272
02:48:05,081 --> 02:48:07,350
A PERSON WITH CHRONIC PAIN IS

4273
02:48:07,350 --> 02:48:09,919
VERY DIFFICULT, MANY PATIENTS

4274
02:48:09,919 --> 02:48:11,020
JUST CAN'T FIND PHYSICIANS TO

4275
02:48:11,020 --> 02:48:15,491
TAKE CARE OF THEM. 

4276
02:48:15,491 --> 02:48:15,959
>> CHRIS?

4277
02:48:15,959 --> 02:48:18,995
>> YEAH, I WANT TO ADD,
I'M PART

4278
02:48:18,995 --> 02:48:22,599
OF THE K12 NETWORK AS WELL, JUST

4279
02:48:22,599 --> 02:48:24,701
WANTED TO ADD THERE THAT THERE'S

4280
02:48:24,701 --> 02:48:27,370
A LARGE EFFORT TO DO AN ATYPICAL

4281
02:48:27,370 --> 02:48:30,707
MENTORSHIP WITH PEOPLE THAT ARE

4282
02:48:30,707 --> 02:48:32,909
IN THAT PROGRAM.

4283
02:48:32,909 --> 02:48:34,344
I'M A PATIENT MENTOR, FOR

4284
02:48:34,344 --> 02:48:36,980
EXAMPLE, IT'S NOT JUST ACADEMIC

4285
02:48:36,980 --> 02:48:39,249
RESEARCH MENTORSHIP BUT CLINICAL

4286
02:48:39,249 --> 02:48:39,649
MENTORSHIP.

4287
02:48:39,649 --> 02:48:41,317
THERE'S COMMUNITY AND PATIENT

4288
02:48:41,317 --> 02:48:42,318
MENTORSHIP AND THERE'S GOALS

4289
02:48:42,318 --> 02:48:45,255
ALONG ALL OF THOSE AREAS, RIGHT?

4290
02:48:45,255 --> 02:48:47,991
SO, IT'S VERY IN DEPTH IN TERMS

4291
02:48:47,991 --> 02:48:51,261
OF WHAT THESE MENTEES HAVE TO DO

4292
02:48:51,261 --> 02:48:52,595
AND WHERE THEIR GOALS ARE AND

4293
02:48:52,595 --> 02:48:53,796
ACTIVITIES THEY ARE GOING TO

4294
02:48:53,796 --> 02:48:56,099
MEET IN EACH ONE OF THESE AREAS,

4295
02:48:56,099 --> 02:48:57,834
RIGHT, FROM SPEAKING TO TALKING

4296
02:48:57,834 --> 02:48:58,601
WITH PEOPLE WITH LIVED

4297
02:48:58,601 --> 02:49:01,437
EXPERIENCE AND HOW THAT IMPACTS

4298
02:49:01,437 --> 02:49:02,839
THEIR RESEARCH.

4299
02:49:02,839 --> 02:49:03,973
SO I'VE BEEN REALLY, REALLY

4300
02:49:03,973 --> 02:49:05,408
PLEASED WITH THAT PROGRAM AND I

4301
02:49:05,408 --> 02:49:07,043
GUESS THE ONLY THING I CAN SAY

4302
02:49:07,043 --> 02:49:09,112
MORE IN SUPPORT IS THAT WE JUST

4303
02:49:09,112 --> 02:49:11,648
NEED MORE FUNDING FOR IT.

4304
02:49:11,648 --> 02:49:13,383
RIGHT NOW WE HAVE I THINK THREE

4305
02:49:13,383 --> 02:49:15,585
MENTEES THAT ARE NOT IN THAT

4306
02:49:15,585 --> 02:49:16,252
PROGRAM.

4307
02:49:16,252 --> 02:49:17,987
WHICH IS A GREAT START.

4308
02:49:17,987 --> 02:49:22,458
YOU KNOW, BUT IN TERMS OF THE

4309
02:49:22,458 --> 02:49:23,760
RESEARCH WORKFORCE NEEDED IN

4310
02:49:23,760 --> 02:49:25,962
CLINICAL PAIN RESEARCH WE NEED

4311
02:49:25,962 --> 02:49:26,930
MORE, RIGHT?

4312
02:49:26,930 --> 02:49:29,766
SO JUST WANTED TO ADD THAT.

4313
02:49:29,766 --> 02:49:31,000
>> YEAH, THANKS, CHRIS.

4314
02:49:31,000 --> 02:49:32,101
WE'RE EXCITED ABOUT THAT

4315
02:49:32,101 --> 02:49:32,502
PROGRAM.

4316
02:49:32,502 --> 02:49:34,704
THE IDEA IS TO BRING IN EACH

4317
02:49:34,704 --> 02:49:39,342
YEAR OVER THE NEXT FIVE YEARS AN

4318
02:49:39,342 --> 02:49:41,477
ADDITIONAL COHORT OF TRAINEES.

4319
02:49:41,477 --> 02:49:44,347
WE FOUND THE FIRST THREE HAVE

4320
02:49:44,347 --> 02:49:45,515
REALLY FOUND SOME ADVANTAGES,

4321
02:49:45,515 --> 02:49:46,849
NOT JUST FROM THE WAY TRAINING

4322
02:49:46,849 --> 02:49:51,120
PROGRAM IS SET UP BUT JUST

4323
02:49:51,120 --> 02:49:52,555
CAREER OPPORTUNITIES ALREADY.

4324
02:49:52,555 --> 02:49:53,856
AND SO IT FEELS GOOD TO SEE THAT

4325
02:49:53,856 --> 02:49:59,662
THEY ARE DOING WELL AND THEY ARE

4326
02:49:59,662 --> 02:50:00,063
FLOURISHING.

4327
02:50:00,063 --> 02:50:01,531
>> FRANCES, PERHAPS THE
LAST

4328
02:50:01,531 --> 02:50:02,198
QUESTION.

4329
02:50:02,198 --> 02:50:02,598
>> YES.

4330
02:50:02,598 --> 02:50:07,003
FIRST, I WILL ECHO WHAT WALTER

4331
02:50:07,003 --> 02:50:09,505
SAID ABOUT NEUROLOGISTS NOT

4332
02:50:09,505 --> 02:50:10,940
BEING AS INVOLVED IN PAIN

4333
02:50:10,940 --> 02:50:12,842
COMPARED TO, SAY, PEOPLE IN

4334
02:50:12,842 --> 02:50:16,512
REHAB MEDICINE OR, YOU KNOW,

4335
02:50:16,512 --> 02:50:17,914
OTHER ANESTHESIA.

4336
02:50:17,914 --> 02:50:22,552
AND ONE AREA THAT NEUROLOGISTS

4337
02:50:22,552 --> 02:50:26,489
TEND TO STILL OWN IS MIGRAINE

4338
02:50:26,489 --> 02:50:26,956
PAIN.

4339
02:50:26,956 --> 02:50:28,558
AND OF COURSE IT WOULD BE

4340
02:50:28,558 --> 02:50:30,326
INTERESTING GIVEN THERE ARE LOTS

4341
02:50:30,326 --> 02:50:31,761
OF PARALLELS, THERE'S THE

4342
02:50:31,761 --> 02:50:34,030
CENTRAL PART, THERE'S ALL OF THE

4343
02:50:34,030 --> 02:50:35,898
ENVIRONMENTAL INFLUENCES,

4344
02:50:35,898 --> 02:50:38,968
THERE'S THE GANGLIA, CRANIAL

4345
02:50:38,968 --> 02:50:41,904
NERVE GANGLIA, NOT MAYBE DORSAL

4346
02:50:41,904 --> 02:50:43,573
ROOT GANGLIA, BUT I'M WONDERING

4347
02:50:43,573 --> 02:50:48,745
IF THERE'S, YOU KNOW, THAT

4348
02:50:48,745 --> 02:50:51,047
COHORT COULD -- THERE COULD BE

4349
02:50:51,047 --> 02:50:54,384
SOME CROSS-FERTILIZATION OF THAT

4350
02:50:54,384 --> 02:50:56,953
COHORT WHICH GENERALLY THERE ARE

4351
02:50:56,953 --> 02:50:59,022
MORE NEUROLOGISTS WHO UNDERSTAND

4352
02:50:59,022 --> 02:51:01,057
THE NEUROAXIS IN A DIFFERENT

4353
02:51:01,057 --> 02:51:04,627
WAY, AND MIGHT BE ABLE TO THINK

4354
02:51:04,627 --> 02:51:05,595
ABOUT SOME COMORBIDITIES,

4355
02:51:05,595 --> 02:51:09,899
WHETHER THAT GROUP COULD BE

4356
02:51:09,899 --> 02:51:11,067
CONNECTED, THEY ARE NIH FUNDED,

4357
02:51:11,067 --> 02:51:12,602
NINDS FUNDED WITH FOLKS DOING

4358
02:51:12,602 --> 02:51:16,005
PERIPHERAL PAIN IN SOME WAY BE

4359
02:51:16,005 --> 02:51:17,640
IT SYMPOSIA OR BRINGING THE TWO

4360
02:51:17,640 --> 02:51:19,409
WORLDS TOGETHER BECAUSE THEY MAY

4361
02:51:19,409 --> 02:51:23,446
NOT BE -- YOU KNOW,

4362
02:51:23,446 --> 02:51:25,181
REPRESENTATIVE DIFFERENT

4363
02:51:25,181 --> 02:51:27,817
CLINICAL DISEASE SETS BUT

4364
02:51:27,817 --> 02:51:28,651
PATHOPHYSIOLOGY MAY BE

4365
02:51:28,651 --> 02:51:31,421
SIGNIFICANTLY SHARED.

4366
02:51:31,421 --> 02:51:32,155
>> THANK YOU, FRANCES.

4367
02:51:32,155 --> 02:51:34,157
AND, YOU KNOW, I TOTALLY AGREE

4368
02:51:34,157 --> 02:51:38,895
WITH YOU THAT THE WORLD OF PAIN

4369
02:51:38,895 --> 02:51:42,065
ON A CRANIAL NERVE AND WORLD OF

4370
02:51:42,065 --> 02:51:43,366
PAIN COMING THROUGH DRGs,

4371
02:51:43,366 --> 02:51:44,367
SOMATIC PAIN, HAVE BEEN

4372
02:51:44,367 --> 02:51:46,536
SEPARATED FOR MANY YEARS.

4373
02:51:46,536 --> 02:51:47,637
THERE'S BEEN SOME

4374
02:51:47,637 --> 02:51:48,337
CROSS-FERTILIZATION, WHEREAS

4375
02:51:48,337 --> 02:51:51,674
UNDERSTANDING OF HOW THE

4376
02:51:51,674 --> 02:51:52,508
TRIPTANES WORK CAPE FROM

4377
02:51:52,508 --> 02:51:54,977
UNDERSTANDING SENSITIZATION AT

4378
02:51:54,977 --> 02:51:59,115
THE LEVEL OF DORSAL HORN, LOWER

4379
02:51:59,115 --> 02:52:00,750
LUMBAR REGION, THE MIGRAINE

4380
02:52:00,750 --> 02:52:03,286
RESEARCHERS TRANSFER THAT TO

4381
02:52:03,286 --> 02:52:06,055
UNDERSTANDING HOW TRIPTANES WORK

4382
02:52:06,055 --> 02:52:07,623
AND TRIGEMINAL GANGLION.

4383
02:52:07,623 --> 02:52:10,760
I WANT TO EMPHASIZE ALL OF THE

4384
02:52:10,760 --> 02:52:11,727
RESEARCH OR FUNDING

4385
02:52:11,727 --> 02:52:15,431
ANNOUNCEMENTS FOR RESEARCH IN

4386
02:52:15,431 --> 02:52:17,200
"HEAL" INCLUDE ABILITY FOR

4387
02:52:17,200 --> 02:52:19,802
TRIGEMINAL PAIN PROJECTS AND

4388
02:52:19,802 --> 02:52:26,476
PROJECTS FOR HEADACHE AND

4389
02:52:26,476 --> 02:52:26,876
MIGRAINE.

4390
02:52:26,876 --> 02:52:28,244
WE'RE CONSTANTLY WORKING TO HAVE

4391
02:52:28,244 --> 02:52:30,213
THEM INCREASE THAT BUT THAT'S

4392
02:52:30,213 --> 02:52:30,613
ONGOING.

4393
02:52:30,613 --> 02:52:33,583
THE THIRD THING I WANT TO SAY IS

4394
02:52:33,583 --> 02:52:36,152
AT THE BEGINNING OF MY TALK I

4395
02:52:36,152 --> 02:52:40,289
TALKED ABOUT THAT 4.7% OF

4396
02:52:40,289 --> 02:52:43,860
SUCCESSFUL PROGRAMS THAT

4397
02:52:43,860 --> 02:52:46,095
HAPPENED WITH NON-ADDICTIVE OSH

4398
02:52:46,095 --> 02:52:50,133
LOW ABUSE LIABILITY ANALGESICS. 

4399
02:52:50,133 --> 02:52:51,667
BASICALLY THEY ARE ALL PROGRAMS

4400
02:52:51,667 --> 02:52:52,869
IN MIGRAINE, ALMOST ALL.

4401
02:52:52,869 --> 02:52:55,805
ONLY ONE THAT'S NOT.

4402
02:52:55,805 --> 02:52:58,374
SO THAT 4.7% IS REALLY, YOU

4403
02:52:58,374 --> 02:52:59,876
KNOW, INFLATED BY THE WORK

4404
02:52:59,876 --> 02:53:01,744
THAT'S HAPPENED IN THE MIGRAINE

4405
02:53:01,744 --> 02:53:02,411
FIELD.

4406
02:53:02,411 --> 02:53:04,680
THE REASON FOR THAT IS BECAUSE

4407
02:53:04,680 --> 02:53:07,750
WAY BACK IN THE '70s THEY

4408
02:53:07,750 --> 02:53:08,818
DETERMINED THAT MEDICATION

4409
02:53:08,818 --> 02:53:13,956
OVERUSE HEADACHE WAS COMING FROM

4410
02:53:13,956 --> 02:53:15,625
OPIOIDS AND BUTALBITOL, DRUGS

4411
02:53:15,625 --> 02:53:19,228
WITH A HIGH ABUSE LIABILITY, USE

4412
02:53:19,228 --> 02:53:20,696
MAKE HEADACHE WORSE AND ACUTE

4413
02:53:20,696 --> 02:53:24,100
MEDICATIONS NOT WORK AS WELL AS

4414
02:53:24,100 --> 02:53:27,303
WELL AS PREVENTIVE MEDICATIONS.

4415
02:53:27,303 --> 02:53:29,605
THEY FIGURED THIS OUT EARLY AND

4416
02:53:29,605 --> 02:53:32,008
WERE GOING AFTER TARGETS THAT

4417
02:53:32,008 --> 02:53:34,610
HAD LOW ADDICTION LIABILITY.

4418
02:53:34,610 --> 02:53:37,480
WHEREAS THE SOMATIC PAIN FIELD

4419
02:53:37,480 --> 02:53:39,415
IS JUST CATCHING UP.

4420
02:53:39,415 --> 02:53:41,817
>> SINCE THAT COMES TO
MIND FROM

4421
02:53:41,817 --> 02:53:42,852
YOUR QUESTION, THE PURPOSE

4422
02:53:42,852 --> 02:53:49,525
NETWORK MIGHT BE A  PLACE TO

4423
02:53:49,525 --> 02:53:51,494
BRING CONVERSATIONS TOGETHER,

4424
02:53:51,494 --> 02:53:54,330
MEANT TO PULL MULTI-DISCIPLINARY

4425
02:53:54,330 --> 02:53:54,697
GROUPS TOGETHER.

4426
02:53:54,697 --> 02:54:05,074
PERHAPS  MICHAEL AND I CAN

4427
02:54:05,074 --> 02:54:06,742
PERHAPS GET THEM -- MAKE A

4428
02:54:06,742 --> 02:54:09,378
CONNECTION THROUGH THAT NETWORK.

4429
02:54:09,378 --> 02:54:10,479
>> ABSOLUTELY.

4430
02:54:10,479 --> 02:54:10,880
>> GREAT.

4431
02:54:10,880 --> 02:54:11,214
OKAY.

4432
02:54:11,214 --> 02:54:14,150
SO, WE DO NEED TO MOVE ON.

4433
02:54:14,150 --> 02:54:17,019
THERE WERE FIVE CONCEPTS THAT

4434
02:54:17,019 --> 02:54:18,554
WERE -- SIX, SORRY.

4435
02:54:18,554 --> 02:54:19,322
SIX CONCEPTS PRESENTED.

4436
02:54:19,322 --> 02:54:21,490
WE DO TAKE A VOTE ON THE

4437
02:54:21,490 --> 02:54:22,325
CONCEPTS MOVING FORWARD.

4438
02:54:22,325 --> 02:54:24,560
THEY WERE BOTH A MIXTURE OF NEW

4439
02:54:24,560 --> 02:54:25,127
AND REISSUES.

4440
02:54:25,127 --> 02:54:28,097
SO WHAT I'M GOING TO CALL FOR IS

4441
02:54:28,097 --> 02:54:29,632
A MOTION TO MOVE FORWARD WITH

4442
02:54:29,632 --> 02:54:33,336
THOSE CONCEPTS.

4443
02:54:33,336 --> 02:54:34,837
>> SO MOVED.

4444
02:54:34,837 --> 02:54:35,605
>> SECOND.

4445
02:54:35,605 --> 02:54:35,938
>> SECONDED.

4446
02:54:35,938 --> 02:54:36,339
>> OKAY, GREAT.

4447
02:54:36,339 --> 02:54:38,574
NOW WE'LL DO THE VOTING IN THE

4448
02:54:38,574 --> 02:54:38,841
ECB.

4449
02:54:38,841 --> 02:54:43,479
SO IF EVERYONE COULD GO TO THE 

4450
02:54:43,479 --> 02:54:44,714
ECB LIKE I MENTIONED, YOU'RE

4451
02:54:44,714 --> 02:54:46,315
GOING TO WANT TO REFRESH YOUR

4452
02:54:46,315 --> 02:54:49,185
SCREEN TO HAVE THE MOST

4453
02:54:49,185 --> 02:54:49,952
UP-TO-DATE VERSION AND YOU'RE

4454
02:54:49,952 --> 02:54:50,820
LOGGED IN.

4455
02:54:50,820 --> 02:54:52,555
GO TO THE VOTING TAB ON THE

4456
02:54:52,555 --> 02:54:54,657
FIRST TAB ON THE LEFT.

4457
02:54:54,657 --> 02:54:57,059
CLICK ON "HEAL" CONCEPT

4458
02:54:57,059 --> 02:54:59,695
CLEARANCE INITIATIVES.

4459
02:54:59,695 --> 02:55:06,569
AND THEN YOU CAN VOTE.

4460
02:55:06,569 --> 02:55:09,372
>> MAYBE WE SHOULD HAVE
THE

4461
02:55:09,372 --> 02:55:12,141
JEOPARDY CLOCK.

4462
02:55:12,141 --> 02:55:17,880
 

4463
02:55:17,880 --> 02:55:27,923
 

4464
02:55:37,433 --> 02:55:40,069
>> WE GOT IT.

4465
02:55:40,069 --> 02:55:40,436
>> THANKS.

4466
02:55:40,436 --> 02:55:40,736
OKAY.

4467
02:55:40,736 --> 02:55:42,571
THANK YOU ALL FOR THE "HEAL"

4468
02:55:42,571 --> 02:55:42,805
SESSION.

4469
02:55:42,805 --> 02:55:45,107
NOW WE'LL MOVE TO THE GENERAL

4470
02:55:45,107 --> 02:55:45,541
CONCEPT CLEARANCE.

4471
02:55:45,541 --> 02:55:48,411
AND SO WHAT WE DO IS PRESENTS

4472
02:55:48,411 --> 02:55:49,712
CONCEPTS TO COUNCIL.

4473
02:55:49,712 --> 02:55:53,316
WE GAVE YOU DETAILED INFORMATION

4474
02:55:53,316 --> 02:55:56,152
IN THE WRITEUPS, IN THE ECB.

4475
02:55:56,152 --> 02:55:59,655
WE HAVE A WEALTH OF CONCEPTS.

4476
02:55:59,655 --> 02:56:03,592
FIRST WE'LL FOCUS ON REISSUES.

4477
02:56:03,592 --> 02:56:05,895
WE HAVE A SLIDES OF THOSE.

4478
02:56:05,895 --> 02:56:06,295
OKAY.

4479
02:56:06,295 --> 02:56:09,398
SO, THE INTENTION IS NOT TO

4480
02:56:09,398 --> 02:56:10,933
MENTION IN DETAIL OR MENTION ANY

4481
02:56:10,933 --> 02:56:12,468
OF THEM EXCEPT FOR ONE WHICH

4482
02:56:12,468 --> 02:56:14,203
I'LL GET TO IN A MINUTE.

4483
02:56:14,203 --> 02:56:17,506
BUT WE'RE HAPPY TO ANSWER

4484
02:56:17,506 --> 02:56:19,809
QUESTIONS IF PEOPLE HAVE THEM.

4485
02:56:19,809 --> 02:56:25,948
I WANT TO FOCUS ON THE NEXT

4486
02:56:25,948 --> 02:56:27,249
SLIDE.

4487
02:56:27,249 --> 02:56:28,451
YES.

4488
02:56:28,451 --> 02:56:31,354
THE VERY LAST REISSUE, THE

4489
02:56:31,354 --> 02:56:33,622
PROGRAM PROJECT GRANT, SO, WE

4490
02:56:33,622 --> 02:56:36,125
HAD ALWAYS ENVISIONED THIS WOULD

4491
02:56:36,125 --> 02:56:41,630
BE SUNSETTED WHEN WE CREATED THE

4492
02:56:41,630 --> 02:56:44,834
RM 1 TEAM SCIENCE PROGRAM,

4493
02:56:44,834 --> 02:56:45,868
THERE'S MULTIPLE.

4494
02:56:45,868 --> 02:56:48,070
THE NUMBER OF APPLICATIONS AND

4495
02:56:48,070 --> 02:56:48,838
AWARDS DECLINED SIGNIFICANTLY

4496
02:56:48,838 --> 02:56:53,976
THAT ONE COULD START TO QUESTION

4497
02:56:53,976 --> 02:56:54,910
ADMINISTRATIVE BURDEN FOR

4498
02:56:54,910 --> 02:56:56,912
APPLICATIONS REVIEW MONITORING

4499
02:56:56,912 --> 02:56:58,381
THE AWARDS, ET CETERA.

4500
02:56:58,381 --> 02:57:00,983
WE BELIEVE THE TIME HAS COME TO

4501
02:57:00,983 --> 02:57:01,484
SUNSET.

4502
02:57:01,484 --> 02:57:04,387
WE CAN DO IT IN TWO WAYS, IF YOU

4503
02:57:04,387 --> 02:57:05,654
HAVE A STRONG ONE.

4504
02:57:05,654 --> 02:57:07,656
ONE, WE DON'T NEED TO REISSUE,

4505
02:57:07,656 --> 02:57:10,726
JUST EXTEND IT FOR REASONS WE

4506
02:57:10,726 --> 02:57:13,129
DON'T NEED TO GET INTO FOR TWO

4507
02:57:13,129 --> 02:57:15,197
ADDITIONAL RECEIPT DATES, MAY

4508
02:57:15,197 --> 02:57:17,066
AND SEPTEMBER DATE.

4509
02:57:17,066 --> 02:57:18,701
WE WOULD BASICALLY SUNSET THE

4510
02:57:18,701 --> 02:57:19,068
PROGRAM.

4511
02:57:19,068 --> 02:57:21,170
OR WHAT WE CAN DO IS EXTEND FOR

4512
02:57:21,170 --> 02:57:23,739
TWO DATES AND DO A FINAL YEAR

4513
02:57:23,739 --> 02:57:25,141
REISSUE FOR THE COMMUNITY SO

4514
02:57:25,141 --> 02:57:29,445
THEY WOULD KNOW. 

4515
02:57:29,445 --> 02:57:30,946
IN BOTH CASES WE'LL PUT OUT A

4516
02:57:30,946 --> 02:57:34,917
NOTICE I WOULD SAY IMMEDIATELY

4517
02:57:34,917 --> 02:57:35,818
AFTER THIS MEETING EXPRESSING

4518
02:57:35,818 --> 02:57:37,019
WHICH WAY WE'RE DOING.

4519
02:57:37,019 --> 02:57:39,188
THE QUESTION IS SHOULD WE DO TWO

4520
02:57:39,188 --> 02:57:43,225
MORE RECEIPT DATES OR FIVE MORE

4521
02:57:43,225 --> 02:57:43,559
RECEIPT DATES.

4522
02:57:43,559 --> 02:57:45,761
AND AS I'M SAYING THIS I'M

4523
02:57:45,761 --> 02:57:47,196
REALLY LOOKING IF THERE'S A

4524
02:57:47,196 --> 02:57:49,698
STRONG PREFERENCE.

4525
02:57:49,698 --> 02:57:55,504
 

4526
02:57:55,504 --> 02:57:57,907
I'M GOING TO TAKE SILENCE AS NOT

4527
02:57:57,907 --> 02:57:58,974
A STRONG PREFERENCE.

4528
02:57:58,974 --> 02:58:03,345
>> NOT STRONG BUT BASED ON

4529
02:58:03,345 --> 02:58:04,680
EVERYTHING I HEARD IT WOULD MAKE

4530
02:58:04,680 --> 02:58:06,882
SENSE TO DO TWO AS OPPOSED TO

4531
02:58:06,882 --> 02:58:07,082
FIVE.

4532
02:58:07,082 --> 02:58:08,517
>> I'M SORRY, I COULDN'T
HEAR

4533
02:58:08,517 --> 02:58:09,151
THAT.

4534
02:58:09,151 --> 02:58:11,921
>> BASED ON WHAT I'VE
HEARD

4535
02:58:11,921 --> 02:58:12,888
TODAY, BUDGETARY CONSTRAINTS,

4536
02:58:12,888 --> 02:58:15,458
WHAT YOU TOLD ABOUT FREQUENCY OF

4537
02:58:15,458 --> 02:58:16,492
THE PROGRAM PROJECTS, IT WOULD

4538
02:58:16,492 --> 02:58:18,494
SEEM TO MAKE SENSE TO GO WITH

4539
02:58:18,494 --> 02:58:22,331
ONLY TWO AS OPPOSED TO THE FIVE.

4540
02:58:22,331 --> 02:58:22,631
>> AGREED.

4541
02:58:22,631 --> 02:58:25,067
SAME REASONS, I HAVE A WEAK

4542
02:58:25,067 --> 02:58:26,168
PREFERENCE FOR TWO.

4543
02:58:26,168 --> 02:58:27,269
>> SAME HERE.

4544
02:58:27,269 --> 02:58:33,709
>> I THINK WHAT WE'LL DO
IS A

4545
02:58:33,709 --> 02:58:34,710
BLOCK CONCEPT CLEARANCE, WE'LL

4546
02:58:34,710 --> 02:58:36,045
KEEP THAT THERE.

4547
02:58:36,045 --> 02:58:37,680
BUT I'VE GOTTEN A SENSE WHICH

4548
02:58:37,680 --> 02:58:38,881
WAY WE'LL GO HERE.

4549
02:58:38,881 --> 02:58:42,117
I MOST IMPORTANT THING IS TO

4550
02:58:42,117 --> 02:58:43,919
ALERT THE COMMUNITY, AS SOON AS

4551
02:58:43,919 --> 02:58:47,723
WE CAN.

4552
02:58:47,723 --> 02:58:49,725
SO IF THERE'S NOT ANY OTHER

4553
02:58:49,725 --> 02:58:53,762
QUESTIONS ON THE P01 OR

4554
02:58:53,762 --> 02:58:54,296
PREFERENCE EXPRESSED,

4555
02:58:54,296 --> 02:58:55,731
EXPRESSING, OR ANY QUESTIONS ON

4556
02:58:55,731 --> 02:58:56,832
THE OTHER REISSUES I WOULD ASK

4557
02:58:56,832 --> 02:58:59,468
FOR A MOTION TO MOVE FORWARD

4558
02:58:59,468 --> 02:59:00,903
WITH ALL OF THOSE.

4559
02:59:00,903 --> 02:59:02,872
>> SO MOVED.

4560
02:59:02,872 --> 02:59:05,274
>> OKAY.

4561
02:59:05,274 --> 02:59:06,141
SECOND?

4562
02:59:06,141 --> 02:59:07,009
>> SECOND.

4563
02:59:07,009 --> 02:59:07,343
>> PERFECT.

4564
02:59:07,343 --> 02:59:12,414
>> WHAT YOU WANT TO DO IS 
GOING

4565
02:59:12,414 --> 02:59:14,283
TO THE VOTING TAB, REISSUE.

4566
02:59:14,283 --> 02:59:15,651
I BELIEVE YOU'LL ONLY SEE TEN AT

4567
02:59:15,651 --> 02:59:16,185
A TIME.

4568
02:59:16,185 --> 02:59:19,421
IF YOU SCROLL TO THE BOTTOM OF

4569
02:59:19,421 --> 02:59:21,724
THE PAGE, YOU CAN INCREASE HOW

4570
02:59:21,724 --> 02:59:25,027
MANY CONCEPTS YOU CAN SEE, SO

4571
02:59:25,027 --> 02:59:26,428
LIKE CLICK 25 OR 100.

4572
02:59:26,428 --> 02:59:30,132
AND THEN YOU CAN DO -- YOU CAN

4573
02:59:30,132 --> 02:59:33,569
VOTE. 

4574
02:59:33,569 --> 02:59:36,839
>> ONE CAN SELECT OUT, I
TAKE

4575
02:59:36,839 --> 02:59:37,406
IT.

4576
02:59:37,406 --> 02:59:38,941
>> CAN YOU?

4577
02:59:38,941 --> 02:59:39,208
>> YES.

4578
02:59:39,208 --> 02:59:40,242
YOU CAN SELECT ALL BUT I BELIEVE

4579
02:59:40,242 --> 02:59:42,111
YOU HAVE TO SHOW ALL THE

4580
02:59:42,111 --> 02:59:46,415
CONCEPTS BEFORE YOU HIT SELECT

4581
02:59:46,415 --> 02:59:47,116
ALL.

4582
02:59:47,116 --> 02:59:49,752
>> VOTING YES MEANS WHAT
WE JUST

4583
02:59:49,752 --> 02:59:50,853
TALKED ABOUT?

4584
02:59:50,853 --> 02:59:51,453
>> YEAH.

4585
02:59:51,453 --> 02:59:52,922
>> VOTE NO ON THAT ONE

4586
02:59:52,922 --> 02:59:53,622
PARTICULAR ONE.

4587
02:59:53,622 --> 02:59:54,990
>> YOU DON'T NEED TO VOTE
NO.

4588
02:59:54,990 --> 02:59:56,425
YOU CAN VOTE YES AND I THINK WE

4589
02:59:56,425 --> 02:59:57,760
HAVE A CLEAR IDEA OF WHAT WE'RE

4590
02:59:57,760 --> 02:59:59,061
GOING TO DO.

4591
02:59:59,061 --> 03:00:00,930
AGAIN, THIS IS JUST -- WHEN WE

4592
03:00:00,930 --> 03:00:02,464
GET CONCEPT CLEARANCE IT DOESN'T

4593
03:00:02,464 --> 03:00:03,666
MEAN WE HAVE TO DO SOMETHING.

4594
03:00:03,666 --> 03:00:05,834
NOW WE HAVE THE ABILITY TO DO

4595
03:00:05,834 --> 03:00:06,201
SOMETHING.

4596
03:00:06,201 --> 03:00:08,704
IT'S EASIER JUST TO VOTE ON THEM

4597
03:00:08,704 --> 03:00:16,912
ALL. 

4598
03:00:16,912 --> 03:00:26,956
 

4599
03:00:28,924 --> 03:00:29,258
>> OKAY.

4600
03:00:29,258 --> 03:00:30,225
THANK YOU FOR THAT.

4601
03:00:30,225 --> 03:00:32,328
NOW WE'LL MOVE TO THE NEW

4602
03:00:32,328 --> 03:00:35,831
CONCEPTS, WE HAVE A COUPLE.

4603
03:00:35,831 --> 03:00:37,800
ONLY ONE WE'RE GOING TO DISCUSS.

4604
03:00:37,800 --> 03:00:45,240
I'M GOING TO PASS TO TISH, WAIT,

4605
03:00:45,240 --> 03:00:46,175
SHE POINTED AT ME.

4606
03:00:46,175 --> 03:00:50,946
>> CHARISSE IS GOING TO GO

4607
03:00:50,946 --> 03:00:51,146
FIRST.

4608
03:00:51,146 --> 03:00:55,451
>> FROM OUR DIVISION OF
CLINICAL

4609
03:00:55,451 --> 03:00:55,718
RESEARCH.

4610
03:00:55,718 --> 03:01:00,122
>> PRESENTATION NUMBER 9.

4611
03:01:00,122 --> 03:01:00,689
>> GREAT.

4612
03:01:00,689 --> 03:01:01,757
TISH IN THE ROOM?

4613
03:01:01,757 --> 03:01:03,092
>> TAKE IT AWAY.

4614
03:01:03,092 --> 03:01:04,727
>> THANK YOU.

4615
03:01:04,727 --> 03:01:07,997
HELLO, EVERYONE. 

4616
03:01:07,997 --> 03:01:11,300
I'M THE PROGRAM DIRECTOR, GLOBAL

4617
03:01:11,300 --> 03:01:13,369
HEALTH AND HEALTH DISPARITIES,

4618
03:01:13,369 --> 03:01:17,106
JOINED BY MY COLLEAGUE TISH TO

4619
03:01:17,106 --> 03:01:22,678
PROVIDE CONCEPT FOR NINDS HEALTH

4620
03:01:22,678 --> 03:01:23,579
EQUITY TRAINING PROGRAM.

4621
03:01:23,579 --> 03:01:25,848
I'M WAITING FOR THE SLIDES ON MY

4622
03:01:25,848 --> 03:01:26,181
END.

4623
03:01:26,181 --> 03:01:27,049
I SEE THEM.

4624
03:01:27,049 --> 03:01:28,417
THANK YOU.

4625
03:01:28,417 --> 03:01:32,988
NEXT SLIDE PLEASE.

4626
03:01:32,988 --> 03:01:36,725
THIS CONCEPT IS A CRITICAL

4627
03:01:36,725 --> 03:01:38,560
COMPONENT OF IMPLEMENTATION OF

4628
03:01:38,560 --> 03:01:40,929
STRATEGIC PLAN, A TWO-YEAR

4629
03:01:40,929 --> 03:01:42,398
PROCESS INVOLVING 30 RESEARCHERS

4630
03:01:42,398 --> 03:01:45,234
AND CLINICAL EXPERTS THAT

4631
03:01:45,234 --> 03:01:47,102
CULMINATED IN TEN MANUSCRIPTS

4632
03:01:47,102 --> 03:01:48,504
OUTLINING RECOMMENDATIONS FOR

4633
03:01:48,504 --> 03:01:51,473
NINDS TO ADDRESS NEUROLOGICAL

4634
03:01:51,473 --> 03:01:53,008
HEALTH DISPARITIES.

4635
03:01:53,008 --> 03:01:54,109
TWO SPECIFICALLY FOCUSED ON

4636
03:01:54,109 --> 03:01:54,543
TRAINING NEEDS.

4637
03:01:54,543 --> 03:01:56,512
I WANT TO POINT OUT HERE OUR

4638
03:01:56,512 --> 03:01:59,448
COLLEAGUES IN THE OFFICE FOR

4639
03:01:59,448 --> 03:02:01,316
PROGRAMS TO ENHANCE DIVERSITY

4640
03:02:01,316 --> 03:02:07,790
WERE ACTIVE CONTRIBUTORS.

4641
03:02:07,790 --> 03:02:09,758
TO ASSURE SUCCESS, THE PIPELINE

4642
03:02:09,758 --> 03:02:20,202
OF NEUROLOGY IS --  FIRST

4643
03:02:23,706 --> 03:02:29,011
MANUSCRIPT ON THE LEFT IS

4644
03:02:29,011 --> 03:02:30,012
AUTHORED, CALLING FOR

4645
03:02:30,012 --> 03:02:31,447
RECRUITMENT AND TRAINING IN

4646
03:02:31,447 --> 03:02:32,948
HEALTH CURRICULA AND DEVELOPMENT

4647
03:02:32,948 --> 03:02:35,584
IN HEALTH DISPARITIES RESEARCH

4648
03:02:35,584 --> 03:02:37,553
AT EARLY, MID-CAREER, SENIOR

4649
03:02:37,553 --> 03:02:38,220
LEVELS, IMPORTANTLY DESCRIBES

4650
03:02:38,220 --> 03:02:40,723
NEED TO TRAIN KEY STAKEHOLDERS

4651
03:02:40,723 --> 03:02:43,125
IN THE COMMUNITY INTEGRAL TO THE

4652
03:02:43,125 --> 03:02:44,660
SUCCESSFUL CONDUCT AND

4653
03:02:44,660 --> 03:02:46,428
DISSEMINATION OF NEUROLOGICAL

4654
03:02:46,428 --> 03:02:47,429
DISPARITIES RESEARCH.

4655
03:02:47,429 --> 03:02:56,839
SECOND MANUSCRIPT ON  RIGHT

4656
03:02:56,839 --> 03:02:58,140
OUTLINES OUTLINES TRAIN

4657
03:02:58,140 --> 03:03:03,078
ACTIVITIES, ONE FOR SCIENTISTS

4658
03:03:03,078 --> 03:03:05,814
OF ALL BACKGROUNDS.

4659
03:03:05,814 --> 03:03:07,349
MULTIPLE RECOMMENDATIONS CAME,

4660
03:03:07,349 --> 03:03:08,884
SOME INCORPORATED INTO PROPOSED

4661
03:03:08,884 --> 03:03:10,853
HEALTH EQUALITY TRAINING PROGRAM

4662
03:03:10,853 --> 03:03:12,488
CONCEPT, I'LL TURN IT OVER TO

4663
03:03:12,488 --> 03:03:14,590
TISH TO PROVIDE MORE DETAILS ON

4664
03:03:14,590 --> 03:03:19,495
THE NEXT SLIDE.

4665
03:03:19,495 --> 03:03:21,663
>> NEXT SLIDE.

4666
03:03:21,663 --> 03:03:24,199
SO, CONCEPT WE'RE PROPOSING IS

4667
03:03:24,199 --> 03:03:25,400
INSTITUTIONAL RESEARCH TRAINING

4668
03:03:25,400 --> 03:03:26,602
PROGRAM NEUROLOGICAL HEALTH

4669
03:03:26,602 --> 03:03:28,170
DISPARITIES AND HEALTH EQUITY

4670
03:03:28,170 --> 03:03:28,437
RESEARCH.

4671
03:03:28,437 --> 03:03:30,672
YOU CAN SEE ACROSS THE TOP IN

4672
03:03:30,672 --> 03:03:32,541
LIGHT BLUE THESE ARE COMPONENTS

4673
03:03:32,541 --> 03:03:36,879
THAT WE ENVISION SO FAR WITH

4674
03:03:36,879 --> 03:03:38,213
RESPECT TO (INDISCERNIBLE) FIRST

4675
03:03:38,213 --> 03:03:39,314
ANCHORED IN RESEARCH PROJECTS

4676
03:03:39,314 --> 03:03:42,284
THAT PARTICIPANTS COULD BE

4677
03:03:42,284 --> 03:03:44,453
UNDERTAKING IN NEUROLOGICAL

4678
03:03:44,453 --> 03:03:46,088
HEALTH DISPARITIES AND PROVIDE

4679
03:03:46,088 --> 03:03:47,856
ADDITIONAL TRAINING AND

4680
03:03:47,856 --> 03:03:49,424
STRATEGIES AND APPROACHES FOR

4681
03:03:49,424 --> 03:03:50,359
BIDIRECTIONAL COMMUNICATION WITH

4682
03:03:50,359 --> 03:03:52,995
THE COMMUNITY AND PEOPLE WITH

4683
03:03:52,995 --> 03:03:53,662
LIVED EXPERIENCE, GIVEN

4684
03:03:53,662 --> 03:03:58,901
EDUCATION INTO THE ROOT CAUSES

4685
03:03:58,901 --> 03:04:01,003
OF HEALTH DILLS PARTIES,

4686
03:04:01,003 --> 03:04:02,304
TRAINING INTO METHODS FOR THIS

4687
03:04:02,304 --> 03:04:04,273
KIND OF WORK.

4688
03:04:04,273 --> 03:04:05,574
WE WOULD EXPECT PROGRAMS WOULD

4689
03:04:05,574 --> 03:04:07,876
BE LED BY A TEAM INCLUDING

4690
03:04:07,876 --> 03:04:09,511
RESEARCHERS AND CLINICIANS,

4691
03:04:09,511 --> 03:04:10,946
PEOPLE FROM THE COMMUNITY, WITH

4692
03:04:10,946 --> 03:04:17,953
LIVED EXPERIENCE, PUBLIC HEALTH

4693
03:04:17,953 --> 03:04:20,923
EXPERTS, FOR GRADUATE, MEDICAL

4694
03:04:20,923 --> 03:04:22,224
STUDENTS, POSTDOCTORAL FELLOWS,

4695
03:04:22,224 --> 03:04:27,129
CLINICIAN ENGAGED IN THIS

4696
03:04:27,129 --> 03:04:27,563
RESEARCH.

4697
03:04:27,563 --> 03:04:29,731
WE WOULD ENDEAVOR TO BE ABLE TO

4698
03:04:29,731 --> 03:04:30,966
ENSURE THAT INSTITUTIONS THAT

4699
03:04:30,966 --> 03:04:33,035
ARE BEST POSITIONED TO PROVIDE

4700
03:04:33,035 --> 03:04:36,772
THIS TYPE OF OUTSTANDING 

4701
03:04:36,772 --> 03:04:38,173
TRAINING WOULD BE COMPETITIVE.

4702
03:04:38,173 --> 03:04:39,942
WITH THE BRIEF INTRODUCTION WE

4703
03:04:39,942 --> 03:04:42,578
HAVE A COUPLE QUESTIONS FOR

4704
03:04:42,578 --> 03:04:43,045
COUNCIL.

4705
03:04:43,045 --> 03:04:44,513
FIRST, ARE THERE OTHER TRAINING

4706
03:04:44,513 --> 03:04:46,415
COMPONENTS THAT SHOULD BE

4707
03:04:46,415 --> 03:04:46,815
INCLUDED?

4708
03:04:46,815 --> 03:04:48,016
SECOND, ARE THERE OTHER

4709
03:04:48,016 --> 03:04:49,017
POPULATIONS THAT SHOULD BE

4710
03:04:49,017 --> 03:04:50,652
TARGETED FOR THIS TYPE OF

4711
03:04:50,652 --> 03:04:52,721
TRAINING?  SO WITH THAT I THANK

4712
03:04:52,721 --> 03:04:53,822
YOU FOR YOUR CONSIDERATION AND

4713
03:04:53,822 --> 03:04:58,427
WE'RE HAPPY TO HEAR YOUR

4714
03:04:58,427 --> 03:05:00,829
FEEDBACK.

4715
03:05:00,829 --> 03:05:03,332
>> THE TITLE OF THIS
MENTIONS

4716
03:05:03,332 --> 03:05:04,967
NEUROLOGICAL CARE.

4717
03:05:04,967 --> 03:05:08,070
NONE OF THE COMPONENTS AND

4718
03:05:08,070 --> 03:05:08,837
DOCUMENTS MENTION NEUROLOGICAL

4719
03:05:08,837 --> 03:05:09,171
ISSUES.

4720
03:05:09,171 --> 03:05:14,209
SO I TAKE IT WILL FOCUS ON

4721
03:05:14,209 --> 03:05:18,280
NEUROLOGICAL DISPARITIES AND 

4722
03:05:18,280 --> 03:05:19,248
NEUROLOGICAL DISEASE AND CARE?

4723
03:05:19,248 --> 03:05:25,787
HOW ABOUT YOU FOCUS ON NEUROLOGY

4724
03:05:25,787 --> 03:05:28,423
OR NEUROSCIENCE ISSUES?

4725
03:05:28,423 --> 03:05:28,757
>> CHARISSE?

4726
03:05:28,757 --> 03:05:32,027
>> YES, THIS IS AN

4727
03:05:32,027 --> 03:05:32,694
INTERESTING -- IMPORTANT

4728
03:05:32,694 --> 03:05:37,799
COMPONENT TO THINK ABOUT HOW

4729
03:05:37,799 --> 03:05:38,500
WE'RE ADDRESSING HEALTH

4730
03:05:38,500 --> 03:05:40,903
DISPARITIES FROM THE

4731
03:05:40,903 --> 03:05:41,770
NEUROLOGICAL PERSPECTIVE, SO THE

4732
03:05:41,770 --> 03:05:43,639
EXPECTATION WOULD BE THAT THERE

4733
03:05:43,639 --> 03:05:49,111
ARE GROUPS OF RESEARCHERS WHO

4734
03:05:49,111 --> 03:05:50,846
HAVE EXPERTISE THINKING HOW TO

4735
03:05:50,846 --> 03:05:52,381
ADDRESS DISPARITIES FROM THE

4736
03:05:52,381 --> 03:05:53,782
EXAMPLE OF EPILEPSY, DISPARITIES

4737
03:05:53,782 --> 03:05:56,218
IN EPILEPSY, BRINGING GROUPS

4738
03:05:56,218 --> 03:05:59,154
TOGETHER THAT BOTH HEALTH EQUITY

4739
03:05:59,154 --> 03:06:00,355
EXPERTISE AND NEUROLOGICAL TO

4740
03:06:00,355 --> 03:06:01,890
BRIDGE THAT GAP SO WE CAN

4741
03:06:01,890 --> 03:06:05,193
ADDRESS DISPARITIES THAT ARE

4742
03:06:05,193 --> 03:06:06,828
OCCURRING WITHIN THIS.

4743
03:06:06,828 --> 03:06:09,564
ABSOLUTELY THE FOCUS WILL BE

4744
03:06:09,564 --> 03:06:17,439
COMPONENT OF NEUROLOGICAL HEALTH

4745
03:06:17,439 --> 03:06:18,540
EQUITY.

4746
03:06:18,540 --> 03:06:20,075
>> CAN YOU DISPLAY THE
LAST

4747
03:06:20,075 --> 03:06:28,383
SLIDE AGAIN. 

4748
03:06:28,383 --> 03:06:32,321
 

4749
03:06:32,321 --> 03:06:33,655
IT'S USEFUL TO SCAN IN TERMS OF

4750
03:06:33,655 --> 03:06:38,460
TRYING TO ANSWER YOUR QUESTION. 

4751
03:06:38,460 --> 03:06:39,594
>> COULD WE PUT THE SLIDE
BACK

4752
03:06:39,594 --> 03:06:41,530
UP WITH THE TRAINING COMPONENTS?

4753
03:06:41,530 --> 03:06:45,701
>> HE'S TRYING TO GET IT
UP, I

4754
03:06:45,701 --> 03:06:46,168
THINK.

4755
03:06:46,168 --> 03:06:48,303
>> OKAY.

4756
03:06:48,303 --> 03:06:53,775
 

4757
03:06:53,775 --> 03:07:03,819
 

4758
03:07:26,875 --> 03:07:28,210
>> DO YOU SEE THIS IN THE

4759
03:07:28,210 --> 03:07:29,511
LABORATORY, IN CLINICS?

4760
03:07:29,511 --> 03:07:30,445
YOU MENTIONED RELATIONSHIP TO

4761
03:07:30,445 --> 03:07:31,813
THE COMMUNITY AS WELL.

4762
03:07:31,813 --> 03:07:34,883
WHERE DO YOU SEE THESE

4763
03:07:34,883 --> 03:07:39,354
COMPONENTS BEING GENERATED AND

4764
03:07:39,354 --> 03:07:39,654
FUNCTIONING?

4765
03:07:39,654 --> 03:07:42,491
>> I THINK THIS WOULD BE

4766
03:07:42,491 --> 03:07:44,426
WHEREVER THESE PROGRAMS WOULD BE

4767
03:07:44,426 --> 03:07:46,161
HOUSED, IF IN CLINICAL

4768
03:07:46,161 --> 03:07:47,262
DEPARTMENT OTHER CLINICAL GROUP

4769
03:07:47,262 --> 03:07:49,765
ARE OR COHORT OF TRAINEES OR

4770
03:07:49,765 --> 03:07:50,866
EVEN JUST AT AN ACADEMIC

4771
03:07:50,866 --> 03:07:52,968
ENVIRONMENT WHERE YOU HAVE

4772
03:07:52,968 --> 03:07:54,369
Ph.D. TRAINEES FOR EXAMPLE

4773
03:07:54,369 --> 03:07:56,571
THEY WOULD BE CARRYING ON NORMAL

4774
03:07:56,571 --> 03:07:57,572
RESEARCH PROJECTS THEY TYPICALLY

4775
03:07:57,572 --> 03:07:59,307
WOULD DO IN THAT ENVIRONMENT BUT

4776
03:07:59,307 --> 03:08:01,510
THEN WOULD BE -- PROGRAM WOULD

4777
03:08:01,510 --> 03:08:04,012
BE EXPECTED TO BUILD OUT

4778
03:08:04,012 --> 03:08:06,982
SPECIFIC TRAINING, A SUITE OF

4779
03:08:06,982 --> 03:08:09,151
TRAINING ACTIVITIES WHETHER

4780
03:08:09,151 --> 03:08:12,554
COURSE WORK, WHETHER

4781
03:08:12,554 --> 03:08:14,122
OPPORTUNITIES FOR HANDS-ON OR

4782
03:08:14,122 --> 03:08:15,824
PRACTICAL WORKSHOPS, ET CETERA,

4783
03:08:15,824 --> 03:08:19,995
TO BE ABLE TO WORK THROUGH, FOR

4784
03:08:19,995 --> 03:08:22,931
EXAMPLE, LEARNING HOW TO

4785
03:08:22,931 --> 03:08:24,132
INTERACT IN BIDIRECTIONA MANNER

4786
03:08:24,132 --> 03:08:25,667
WITH COMMUNITIES YOU WOULD BE

4787
03:08:25,667 --> 03:08:26,768
ENGAGING WITH.

4788
03:08:26,768 --> 03:08:28,103
AND WITH RESPECT TO, FOR

4789
03:08:28,103 --> 03:08:28,937
EXAMPLE, TRAINING AND RESEARCH

4790
03:08:28,937 --> 03:08:34,109
METHODS THAT COULD BE SOMETHING 

4791
03:08:34,109 --> 03:08:40,115
THAT'S DIDACTIC, BOOT CAMP

4792
03:08:40,115 --> 03:08:41,316
BASED, LEFT TO THE PROGRAMS TO

4793
03:08:41,316 --> 03:08:44,052
COME UP WITH SOMETHING THAT

4794
03:08:44,052 --> 03:08:45,053
WORKS WITH RESOURCES AND

4795
03:08:45,053 --> 03:08:45,620
INFRASTRUCTURE IN THE

4796
03:08:45,620 --> 03:08:47,122
ENVIRONMENT THEY PROPOSE TO DO

4797
03:08:47,122 --> 03:08:47,756
THE TRAINING IN.

4798
03:08:47,756 --> 03:08:58,033
>> THANK YOU. 

4799
03:08:58,467 --> 03:09:00,268
 

4800
03:09:00,268 --> 03:09:00,836
 

4801
03:09:00,836 --> 03:09:01,269
>> DID THAT HELP?

4802
03:09:01,269 --> 03:09:02,904
>> YES.

4803
03:09:02,904 --> 03:09:10,112
IN THE CONTEXT OF GWAS IN THE

4804
03:09:10,112 --> 03:09:12,314
AFRICAN POPULATION, SOME

4805
03:09:12,314 --> 03:09:13,215
CATEGORIES WE'RE FRIGHTENINGLY

4806
03:09:13,215 --> 03:09:13,515
HOMOGENOUS.

4807
03:09:13,515 --> 03:09:16,818
I DO A LOT OF ALS WORK.

4808
03:09:16,818 --> 03:09:19,254
IT'S PHENOMENALLY HOMOGENOUS

4809
03:09:19,254 --> 03:09:22,023
WITH RESPECT TO WHITE PATIENTS.

4810
03:09:22,023 --> 03:09:25,260
AND SO IT WOULD BE NICE TO THINK

4811
03:09:25,260 --> 03:09:29,664
ABOUT HOW TO GET INTO THE ARENAS

4812
03:09:29,664 --> 03:09:32,067
WHERE ONE MIGHT SEE OTHER

4813
03:09:32,067 --> 03:09:34,469
ASPECTS OF NEUROLOGICAL DISEASES

4814
03:09:34,469 --> 03:09:38,406
BASED ON DIVERSITY.

4815
03:09:38,406 --> 03:09:38,940
>> GINA?

4816
03:09:38,940 --> 03:09:39,841
>> YES.

4817
03:09:39,841 --> 03:09:40,375
HELLO.

4818
03:09:40,375 --> 03:09:42,777
I LOVE THIS CONCEPT.

4819
03:09:42,777 --> 03:09:44,179
AND HISTORY TELLS US THAT IT'S

4820
03:09:44,179 --> 03:09:46,715
GOING TO TAKE MORE THAN JUST A

4821
03:09:46,715 --> 03:09:49,584
LITTLE BIT OF WINDOW DRESSING TO

4822
03:09:49,584 --> 03:09:51,553
GET THIS DONE.

4823
03:09:51,553 --> 03:09:53,388
SO I'M APPLAUDING THE WHOLE

4824
03:09:53,388 --> 03:09:58,226
EFFORT AND THE FACT THAT YOU ARE

4825
03:09:58,226 --> 03:10:03,598
GOING TO TAILOR THE TRAINING

4826
03:10:03,598 --> 03:10:04,666
COMPONENTS TO THE SPECIFIC NEEDS

4827
03:10:04,666 --> 03:10:08,069
OF THE PLACE.

4828
03:10:08,069 --> 03:10:10,238
IT MIGHT BE THAT SOMEPLACE MIGHT

4829
03:10:10,238 --> 03:10:13,642
NEED TO BE SUPPORTED FOR YEARS

4830
03:10:13,642 --> 03:10:15,443
BECAUSE CONCEPT NEEDS TIME TO

4831
03:10:15,443 --> 03:10:17,045
CHANGE AND PEOPLE'S MINDS NEED

4832
03:10:17,045 --> 03:10:18,780
TIME TO CHANGE.

4833
03:10:18,780 --> 03:10:22,717
SO I JUST WANTED TO SUPPORT THIS

4834
03:10:22,717 --> 03:10:24,186
WHOLE EFFORT AND SAY THAT THIS

4835
03:10:24,186 --> 03:10:26,221
IS NOT SOMETHING THAT CAN BE

4836
03:10:26,221 --> 03:10:27,589
DONE OVERNIGHT UNLESS THERE ARE

4837
03:10:27,589 --> 03:10:29,424
PLACES THAT ARE PRIMED AND READY

4838
03:10:29,424 --> 03:10:30,192
FOR IT.

4839
03:10:30,192 --> 03:10:31,426
BUT OTHER PLACES ARE GOING TO

4840
03:10:31,426 --> 03:10:32,928
NEED A LOT OF WORK.

4841
03:10:32,928 --> 03:10:42,070
SO THANK YOU FOR UNDERTAKING

4842
03:10:42,070 --> 03:10:42,270
THIS.

4843
03:10:42,270 --> 03:10:43,872
>> THIS IS A DIFFERENT
KIND OF

4844
03:10:43,872 --> 03:10:46,608
TRAINING PROGRAM, MIGHT BE FOCUS

4845
03:10:46,608 --> 03:10:50,579
JUST ON POSTDOCS, MAYBE FELLOWS

4846
03:10:50,579 --> 03:10:52,581
AND POSTDOCS, CURIOUS HOW DO YOU

4847
03:10:52,581 --> 03:10:57,018
PLAN TO NAVIGATE IN TERMS OF

4848
03:10:57,018 --> 03:10:59,187
HAVING THE FLEXIBILITY AND

4849
03:10:59,187 --> 03:11:01,089
THE -- PROBABLY THE EXTENT OF

4850
03:11:01,089 --> 03:11:02,457
INVOLVEMENT AT A GIVEN PLACE FOR

4851
03:11:02,457 --> 03:11:04,359
THE TRAINING PROGRAM TO WORK

4852
03:11:04,359 --> 03:11:06,695
EFFECTIVELY, BUT THEN AGAIN I DO

4853
03:11:06,695 --> 03:11:09,397
SUPPORT THIS.

4854
03:11:09,397 --> 03:11:11,466
>> AGAIN, I THINK IT'S
GOING TO

4855
03:11:11,466 --> 03:11:13,134
DEPENDS -- WE'LL HAVE TO WRITE

4856
03:11:13,134 --> 03:11:16,304
THIS IN A WAY TO MAKE SURE THAT

4857
03:11:16,304 --> 03:11:18,607
IT'S GOING TO BE FEASIBLE FOR

4858
03:11:18,607 --> 03:11:20,575
DIFFERENT FOLKS WITH DIFFERENT

4859
03:11:20,575 --> 03:11:21,109
POPULATIONS.

4860
03:11:21,109 --> 03:11:22,544
AND DIFFERENT MIXES OF PEOPLE TO

4861
03:11:22,544 --> 03:11:23,745
BE ABLE TO PUT TOGETHER

4862
03:11:23,745 --> 03:11:25,947
SOMETHING THAT THEN IS GOING TO

4863
03:11:25,947 --> 03:11:27,148
MEET -- TICK ALL THE BOXES BUT

4864
03:11:27,148 --> 03:11:27,949
ALSO SPECIFIC FOR THEIR

4865
03:11:27,949 --> 03:11:28,383
ENVIRONMENT.

4866
03:11:28,383 --> 03:11:30,352
I THINK WE'LL HAVE TO THINK

4867
03:11:30,352 --> 03:11:33,121
CAREFULLY HOW WE WRITE UP THE

4868
03:11:33,121 --> 03:11:33,788
INITIATIVE, CERTAINLY TALKING TO

4869
03:11:33,788 --> 03:11:36,391
PEOPLE IN THE COMMUNITY TO GET

4870
03:11:36,391 --> 03:11:38,026
FEEDBACK TO SEE WHAT'S BEST

4871
03:11:38,026 --> 03:11:41,196
SUITED TO BE ABLE TO HAVE THE

4872
03:11:41,196 --> 03:11:45,233
BROADEST REACH, EVEN THOUGH THIS

4873
03:11:45,233 --> 03:11:48,303
IS ONE INITIATIVE.

4874
03:11:48,303 --> 03:11:48,603
>> LOUISE?

4875
03:11:48,603 --> 03:11:49,704
>> I ECHO THE COMMENTS.

4876
03:11:49,704 --> 03:11:51,706
ONE CONCERN IS REALLY JUST

4877
03:11:51,706 --> 03:11:53,908
OPERATIONALIZING IT.

4878
03:11:53,908 --> 03:11:55,410
LIKE MAKING SURE THE COMMUNITY

4879
03:11:55,410 --> 03:11:56,745
RESOURCES ARE SET UP BECAUSE

4880
03:11:56,745 --> 03:11:59,014
IT'S GREAT AND PEOPLE WANT

4881
03:11:59,014 --> 03:12:01,216
TRAINING AND WE WANT TO INCREASE

4882
03:12:01,216 --> 03:12:02,851
DIVERSITY AND INCLUSION BUT SOME

4883
03:12:02,851 --> 03:12:06,621
PLACES MAY NOT HAVE THIS 

4884
03:12:06,621 --> 03:12:08,023
INFRASTRUCTURE AND IT REQUIRES A

4885
03:12:08,023 --> 03:12:10,425
LOT OF COMMUNITY NETWORKING TO

4886
03:12:10,425 --> 03:12:12,060
GET THE COMMUNITIES ON BOARD

4887
03:12:12,060 --> 03:12:13,161
BECAUSE THAT'S WHO WE'RE TRYING

4888
03:12:13,161 --> 03:12:14,062
TO REACH.

4889
03:12:14,062 --> 03:12:16,698
SO KIND OF THINKING ABOUT MAYBE

4890
03:12:16,698 --> 03:12:18,433
EVEN INCLUDING COMMUNITY HEALTH

4891
03:12:18,433 --> 03:12:22,037
WORKERS, WHICH ARE GOOD BRIDGE

4892
03:12:22,037 --> 03:12:24,873
BETWEEN A PARTICULAR COMMUNITY,

4893
03:12:24,873 --> 03:12:27,475
BILINGUAL, LANGUAGE BARRIERS.

4894
03:12:27,475 --> 03:12:28,710
JUST OPERATIONALIZING SO IT

4895
03:12:28,710 --> 03:12:30,779
ACHIEVES WHAT YOU WANT IT TO

4896
03:12:30,779 --> 03:12:33,615
ACHIEVE, YOU KNOW, SO WE CAN

4897
03:12:33,615 --> 03:12:34,749
DISSEMINATE AND IMPLEMENT TO

4898
03:12:34,749 --> 03:12:37,152
OTHER PLACES IS GOING TO BE THE

4899
03:12:37,152 --> 03:12:37,786
TRICK HERE.

4900
03:12:37,786 --> 03:12:39,788
I'M SURE WITH YOUR GUIDANCE IT

4901
03:12:39,788 --> 03:12:40,955
WILL GO VERY WELL.

4902
03:12:40,955 --> 03:12:45,560
IT'S JUST TRYING TO GET TO THAT

4903
03:12:45,560 --> 03:12:46,761
ACTUAL, YOU KNOW, OBJECTIONABLE

4904
03:12:46,761 --> 03:12:49,297
OR OBJECTIVE THAT YOU WANT THIS

4905
03:12:49,297 --> 03:12:50,699
PROGRAM TO HAVE.

4906
03:12:50,699 --> 03:12:51,066
>> ABSOLUTELY.

4907
03:12:51,066 --> 03:12:53,201
YES, THANK YOU FOR THAT COMMENT.

4908
03:12:53,201 --> 03:12:56,805
YEAH, THAT'S A GOOD SEGUE TO

4909
03:12:56,805 --> 03:13:00,108
MENTION THIS IS ONE COMPONENT OF

4910
03:13:00,108 --> 03:13:01,109
OUR IMPLEMENTATION OF HEALTH

4911
03:13:01,109 --> 03:13:02,844
EQUITY STRATEGIC PLAN AND SO WE

4912
03:13:02,844 --> 03:13:05,780
DON'T EXPECT THAT ONE PROGRAM

4913
03:13:05,780 --> 03:13:06,448
ALONE WILL SERVE TO DEAL WITH

4914
03:13:06,448 --> 03:13:09,384
ALL OF THE ISSUES THAT WE WANT

4915
03:13:09,384 --> 03:13:11,252
TO TACKLE AND SO THIS DOES

4916
03:13:11,252 --> 03:13:11,519
DOVETAIL.

4917
03:13:11,519 --> 03:13:14,022
THIS IS WHY WE DEVELOPED THIS

4918
03:13:14,022 --> 03:13:16,324
COLLABORATION TO ENSURE THAT IT

4919
03:13:16,324 --> 03:13:19,060
WORKED WELL WITH THE, FOR

4920
03:13:19,060 --> 03:13:20,362
EXAMPLE, COMMUNITY ENGAGED

4921
03:13:20,362 --> 03:13:22,330
HEALTH EQUALITY RESEARCH

4922
03:13:22,330 --> 03:13:23,531
INITIATIVE WE PRESENTED LAST

4923
03:13:23,531 --> 03:13:28,036
YEAR, THAT IS IN THE WORKS AND

4924
03:13:28,036 --> 03:13:31,539
WE FULLY ANTICIPATE LESSONS

4925
03:13:31,539 --> 03:13:33,308
LEARNED AND RESEARCHERS AWARDED

4926
03:13:33,308 --> 03:13:35,043
THROUGH THE HERN WILL WORK WITH

4927
03:13:35,043 --> 03:13:37,812
THESE GROUPS AS WELL.

4928
03:13:37,812 --> 03:13:42,283
WE'RE ESSENTIALLY BUILDING THE

4929
03:13:42,283 --> 03:13:43,685
NEXT GENERATION THROUGH

4930
03:13:43,685 --> 03:13:45,253
DISPARITIES, NEUROLOGICAL HEALTH

4931
03:13:45,253 --> 03:13:46,388
DISPARITIES RESEARCHERS,

4932
03:13:46,388 --> 03:13:47,956
INVESTIGATORS, REALLY TRYING TO

4933
03:13:47,956 --> 03:13:50,058
DO THAT IN COLLABORATIVE WAY.

4934
03:13:50,058 --> 03:13:54,562
>> I DON'T WANT TO SLOW US
DOWN

4935
03:13:54,562 --> 03:13:56,398
BUT DO YOU ENVISION A POSSIBLE

4936
03:13:56,398 --> 03:14:03,405
TO HAVE A MAJOR UNIVERSITY

4937
03:14:03,405 --> 03:14:04,072
PARTNERING WITH ININSTITUTION

4938
03:14:04,072 --> 03:14:05,840
PRIMED TO BE MAJOR BUT DOESN'T

4939
03:14:05,840 --> 03:14:07,575
HAVE THE STRUCTURE, A JOINT

4940
03:14:07,575 --> 03:14:09,110
TRAINING GRANT PROGRAM OR THREE

4941
03:14:09,110 --> 03:14:11,312
UNIVERSITIES, IS THAT WHAT YOU

4942
03:14:11,312 --> 03:14:12,080
ENVISION?

4943
03:14:12,080 --> 03:14:13,615
>> I THINK THIS IS
SOMETHING WE

4944
03:14:13,615 --> 03:14:15,016
STARTED TALKING ABOUT FROM THE

4945
03:14:15,016 --> 03:14:16,885
FIRST TIME WE DISCUSSED THIS.

4946
03:14:16,885 --> 03:14:19,254
AND FIGURING OUT A WAY TO

4947
03:14:19,254 --> 03:14:20,822
POTENTIALLY BE ABLE TO DO THIS.

4948
03:14:20,822 --> 03:14:24,559
IT CAN BE TRICKY BUT THERE MAY

4949
03:14:24,559 --> 03:14:26,394
BE SOME CASES WHERE THIS MIGHT

4950
03:14:26,394 --> 03:14:27,295
WORK REALLY, REALLY WELL AND

4951
03:14:27,295 --> 03:14:30,165
WOULD BE A GREAT WAY TO BRING

4952
03:14:30,165 --> 03:14:32,534
GROUPS THAT DON'T MAYBE HAVE

4953
03:14:32,534 --> 03:14:34,269
RESOURCES IN HOUSE INTO THE

4954
03:14:34,269 --> 03:14:35,703
CONVERSATION AND TRAINING.

4955
03:14:35,703 --> 03:14:41,376
SO IT'S SOMETHING ON THE RADAR.

4956
03:14:41,376 --> 03:14:43,478
>> SAMEER?

4957
03:14:43,478 --> 03:14:43,912
>> THANKS.

4958
03:14:43,912 --> 03:14:44,779
LET ME INTERJECT.

4959
03:14:44,779 --> 03:14:51,152
LOTS OF DISCUSSIONS ABOUT THIS,

4960
03:14:51,152 --> 03:14:52,220
QUESTIONS NOT REALLY EXPLAINED.

4961
03:14:52,220 --> 03:14:56,591
THE ISSUE IS THE MECHANISM.

4962
03:14:56,591 --> 03:14:58,793
T32, THE T32 DOES NOT ALLOW

4963
03:14:58,793 --> 03:15:00,328
NON-CITIZENS, THAT'S ONE THING

4964
03:15:00,328 --> 03:15:01,729
TO CONSIDER.

4965
03:15:01,729 --> 03:15:07,335
T32s ARE GOING TO BE VERY MUCH

4966
03:15:07,335 --> 03:15:11,172
ACADEMIC ORIENTED PLACES, AND

4967
03:15:11,172 --> 03:15:12,273
QUESTIONS FOR DOING HEALTH

4968
03:15:12,273 --> 03:15:13,575
RESEARCH, IS THAT THE POOL OF

4969
03:15:13,575 --> 03:15:17,879
PEOPLE WE WANT TO CONCENTRATE

4970
03:15:17,879 --> 03:15:21,149
ON, PEOPLE THAT DON'T HAVE

4971
03:15:21,149 --> 03:15:24,118
AGREES, DON'T HAVE PhDs,

4972
03:15:24,118 --> 03:15:26,187
M.D.s, SO THE QUESTIONS THAT

4973
03:15:26,187 --> 03:15:29,691
WE WERE ASKING WERE TO DO HEALTH

4974
03:15:29,691 --> 03:15:30,692
DISPARITIES RESEARCH WHAT ARE

4975
03:15:30,692 --> 03:15:34,829
THE KIND OF PEOPLE WE NEED TO

4976
03:15:34,829 --> 03:15:37,131
GET AND IS THE USUAL T32

4977
03:15:37,131 --> 03:15:40,502
MECHANISM THE RIGHT WAY TO DO

4978
03:15:40,502 --> 03:15:41,069
IT?

4979
03:15:41,069 --> 03:15:47,976
UNFORTUNATELY THAT WASN'T MADE 

4980
03:15:47,976 --> 03:15:56,818
EXPLICIT TO THE COUNCIL.

4981
03:15:56,818 --> 03:15:58,786
>> WHAT'S REALLY NICE, A
LOT OF

4982
03:15:58,786 --> 03:16:00,088
WORK WENTZ INTO THE STRATEGIC

4983
03:16:00,088 --> 03:16:03,157
PLAN, THERE'S A LOT TO DO.

4984
03:16:03,157 --> 03:16:05,627
IT'S GREAT THAT WE'RE STARTING,

4985
03:16:05,627 --> 03:16:10,832
YOU'RE STARTING AT A GRASSROOTS

4986
03:16:10,832 --> 03:16:11,165
LEVEL.

4987
03:16:11,165 --> 03:16:15,436
THIS IS AN INVESTMENT INTO THE 

4988
03:16:15,436 --> 03:16:15,870
FUTURE.

4989
03:16:15,870 --> 03:16:17,505
YOU KNOW, THE FOLLOWING YEAR OR

4990
03:16:17,505 --> 03:16:19,374
YEAR AFTER THAT, THREE, FIVE,

4991
03:16:19,374 --> 03:16:22,110
TEN YEARS DOWN THE LINE WILL BE

4992
03:16:22,110 --> 03:16:25,046
LEADING THIS.

4993
03:16:25,046 --> 03:16:25,947
THAT MAGNIFICATION, MAGNIFYING

4994
03:16:25,947 --> 03:16:28,449
EFFECT, YOU KNOW, IS AN

4995
03:16:28,449 --> 03:16:29,684
INVESTMENT, LIKE ALL OF OUR

4996
03:16:29,684 --> 03:16:30,985
TRAINING GRANTS IT REALLY PAYS

4997
03:16:30,985 --> 03:16:31,653
OFF WELL.

4998
03:16:31,653 --> 03:16:35,557
IT'S A GREAT PLACE TO START.

4999
03:16:35,557 --> 03:16:39,494
WITH THE COMMENTS THAT WALTER

5000
03:16:39,494 --> 03:16:42,030
MADE, IT'S ATYPICAL, AND IS

5001
03:16:42,030 --> 03:16:43,998
GOING TO REQUIRE MAYBE

5002
03:16:43,998 --> 03:16:44,732
NON-TRADITIONAL MECHANISMS TO

5003
03:16:44,732 --> 03:16:47,735
GET IT TO THE PEOPLE THAT ARE

5004
03:16:47,735 --> 03:16:50,471
REALLY GOING TO BE THE SOLDIERS

5005
03:16:50,471 --> 03:16:53,041
FOR THIS, TO MAKE THIS HAPPEN.

5006
03:16:53,041 --> 03:16:54,876
SO IT WILL BE INTERESTING TO SEE

5007
03:16:54,876 --> 03:17:01,549
HOW YOU CAN FIGURE THAT OUT.

5008
03:17:01,549 --> 03:17:02,750
MECHANISM WISE.

5009
03:17:02,750 --> 03:17:03,017
>> GINA?

5010
03:17:03,017 --> 03:17:05,687
>> I THINK THERE'S A WAY
TO NOT

5011
03:17:05,687 --> 03:17:07,989
NECESSARILY REINVENT THE WHEEL

5012
03:17:07,989 --> 03:17:08,556
HERE.

5013
03:17:08,556 --> 03:17:13,695
I THINK IT'S QUITE --

5014
03:17:13,695 --> 03:17:16,197
MECHANISM-WISE ONE CAN HAVE

5015
03:17:16,197 --> 03:17:20,001
WEEKLY IDEA SALON WHERE HAVE YOU

5016
03:17:20,001 --> 03:17:24,072
TRAINEES THAT -- ALSO INVITE

5017
03:17:24,072 --> 03:17:26,274
COMMUNITY MEMBERS LIKE COMMUNITY

5018
03:17:26,274 --> 03:17:31,079
COALITIONS OF SOME SORT TO COME 

5019
03:17:31,079 --> 03:17:32,614
AND SHARE KNOWLEDGE AND IDEAS.

5020
03:17:32,614 --> 03:17:35,149
THERE MIGHT BE A WAY TO -- I

5021
03:17:35,149 --> 03:17:37,619
THINK YOU MAKE A REALLY GOOD

5022
03:17:37,619 --> 03:17:39,187
POINT, SAMEER, THERE MIGHT BE

5023
03:17:39,187 --> 03:17:44,425
THE NEED TO FIND A WAY TO GET 

5024
03:17:44,425 --> 03:17:46,728
MONEY TO COMMUNITY MEMBERS THAT

5025
03:17:46,728 --> 03:17:48,162
HASN'T BEEN TRADITIONAL DONE BUT

5026
03:17:48,162 --> 03:17:50,365
I DON'T THINK THAT'S -- IT'S

5027
03:17:50,365 --> 03:17:51,532
PROBABLY NOT THE FIRST TIME

5028
03:17:51,532 --> 03:17:52,634
THAT'S BEEN DONE SO I'M SURE

5029
03:17:52,634 --> 03:17:56,337
THERE'S A WAY AND I WONDER WHAT

5030
03:17:56,337 --> 03:18:00,975
TISH AND OTHERS HAVE THOUGHT

5031
03:18:00,975 --> 03:18:01,609
ABOUT THAT.

5032
03:18:01,609 --> 03:18:03,911
>> I THINK THAT OUR
THINKING, WE

5033
03:18:03,911 --> 03:18:06,214
STEPPED BACK FROM A SPECIFIC

5034
03:18:06,214 --> 03:18:08,082
MECHANISM AND WANTED TO THINK

5035
03:18:08,082 --> 03:18:09,384
ABOUT WHAT IS NEEDED, WHO NEEDS

5036
03:18:09,384 --> 03:18:11,452
TO BE TRAINED, AND WE CAN PLUG

5037
03:18:11,452 --> 03:18:13,655
IT INTO ONE OR MORE MECHANISMS,

5038
03:18:13,655 --> 03:18:16,057
AND THERE COULD BE COMPANION

5039
03:18:16,057 --> 03:18:19,794
MECHANISMS TO MAKE SURE THAT WE

5040
03:18:19,794 --> 03:18:21,429
ARE -- WHATEVER LIMITATIONS WE

5041
03:18:21,429 --> 03:18:23,698
HAVE WITH DIFFERENT MECHANISMS

5042
03:18:23,698 --> 03:18:25,900
WE CAN MAXIMIZE THOSE AND REALLY

5043
03:18:25,900 --> 03:18:27,335
TARGET THE GROUPS THAT NEED TO

5044
03:18:27,335 --> 03:18:28,436
BE TARGETED WITH TRAINING THEY

5045
03:18:28,436 --> 03:18:29,604
NEED TO GET.

5046
03:18:29,604 --> 03:18:32,140
IT DOESN'T HAVE TO BE T32, R25,

5047
03:18:32,140 --> 03:18:33,775
IT COULD BE BOTH, OTHER THINGS,

5048
03:18:33,775 --> 03:18:37,512
BUT I THINK THAT'S WHAT BEEF GOT

5049
03:18:37,512 --> 03:18:40,581
 -- WE'VE GOT TO THINK OUT.

5050
03:18:40,581 --> 03:18:42,850
WHAT INFORMATION AND WHAT

5051
03:18:42,850 --> 03:18:44,285
MECHANISMS WILL ALLOW THAT.

5052
03:18:44,285 --> 03:18:45,386
>> THANK YOU.

5053
03:18:45,386 --> 03:18:46,921
>> SO, YEAH, AGAIN WHEN WE
VOTE

5054
03:18:46,921 --> 03:18:48,890
ON THESE CONCEPTS WE DON'T

5055
03:18:48,890 --> 03:18:50,425
NECESSARILY HAVE TO HAVE THE

5056
03:18:50,425 --> 03:18:53,828
GORY DETAILS BUT IT'S THE BIG

5057
03:18:53,828 --> 03:18:54,328
CONCEPT.

5058
03:18:54,328 --> 03:18:55,663
SOUNDS LIKE THERE'S A GREAT DEAL

5059
03:18:55,663 --> 03:18:57,432
OF SUPPORT FORETHAT.

5060
03:18:57,432 --> 03:19:00,501
WHAT WE'LL DO NOW IS MOVE

5061
03:19:00,501 --> 03:19:01,903
FORWARD.

5062
03:19:01,903 --> 03:19:03,004
THERE WERE THREE NEW CONCEPTS.

5063
03:19:03,004 --> 03:19:05,606
AND SO WE'RE GOING TO VOTE ON

5064
03:19:05,606 --> 03:19:06,507
THOSE UNLESS THERE WERE

5065
03:19:06,507 --> 03:19:09,544
QUESTIONS ON THE OTHER TWO.

5066
03:19:09,544 --> 03:19:11,312
WELL, FIRST, WE'LL MAKE A

5067
03:19:11,312 --> 03:19:11,846
MOTION.

5068
03:19:11,846 --> 03:19:13,681
MOTION TO MOVE --

5069
03:19:13,681 --> 03:19:14,816
>> SO MOVED.

5070
03:19:14,816 --> 03:19:15,683
>> THANK YOU.

5071
03:19:15,683 --> 03:19:24,425
VOTE AWAY ON THOSE THREE.

5072
03:19:24,425 --> 03:19:29,297
IN THE MEANTIME ROD CORRIVEAU

5073
03:19:29,297 --> 03:19:30,231
WILL PRESENT AD/ADRD TO THE

5074
03:19:30,231 --> 03:19:32,200
COUNCIL AND WE'RE GOING TO MOVE

5075
03:19:32,200 --> 03:19:42,510
FORWARD ON THOSE.

5076
03:19:42,910 --> 03:19:43,010
ROD?

5077
03:19:43,010 --> 03:19:44,245
>> I'M HERE.

5078
03:19:44,245 --> 03:19:54,655
>> TAKE IT AWAY, ROD.

5079
03:20:01,496 --> 03:20:03,598
>> OKAY.

5080
03:20:03,598 --> 03:20:07,769
>> I PROMISE NOT TO TAKE
LONG

5081
03:20:07,769 --> 03:20:08,736
TODAY.

5082
03:20:08,736 --> 03:20:11,606
I WANT TO JUST MENTION THE

5083
03:20:11,606 --> 03:20:14,375
AD/ADRD PROGRAM IS A LARGE

5084
03:20:14,375 --> 03:20:15,510
PROGRAM AT THE NINDS.

5085
03:20:15,510 --> 03:20:18,079
WALTER ALREADY MENTIONED THAT

5086
03:20:18,079 --> 03:20:19,013
IT'S AROUND $300 MILLION PER

5087
03:20:19,013 --> 03:20:22,216
YEAR, THERE ARE MANY PEOPLE

5088
03:20:22,216 --> 03:20:22,884
INVOLVED.

5089
03:20:22,884 --> 03:20:23,518
AND MANY PROGRAMS INVOLVED, A

5090
03:20:23,518 --> 03:20:28,022
LOT OF PEOPLE TO THANK, A LOT OF

5091
03:20:28,022 --> 03:20:32,059
HARD WORK FROM REVIEW PROGRAM 

5092
03:20:32,059 --> 03:20:34,228
OFFICE OF THE DIRECTOR AND

5093
03:20:34,228 --> 03:20:35,463
COLLABORATION WITH ESPECIALLY

5094
03:20:35,463 --> 03:20:39,400
THE NIA AND OTHER INSTITUTES.

5095
03:20:39,400 --> 03:20:41,536
THE FIRST GOAL OF THE NATIONAL

5096
03:20:41,536 --> 03:20:43,671
PLAN TO ADDRESS ALZHEIMER'S

5097
03:20:43,671 --> 03:20:46,307
DISEASE IS TO PREVENT AND

5098
03:20:46,307 --> 03:20:49,577
EFFECTIVELY TREAT ALZHEIMER'S

5099
03:20:49,577 --> 03:20:52,079
DISEASE AND RELATED DEMENTIAS.

5100
03:20:52,079 --> 03:20:54,949
IN PURSUIT OF THAT GOAL THERE

5101
03:20:54,949 --> 03:20:57,552
ARE TRIENNIAL SUMMITS ON

5102
03:20:57,552 --> 03:21:00,421
ALZHEIMER'S DISEASE, ALZHEIMER'S

5103
03:21:00,421 --> 03:21:01,722
DISEASE RELATED DEMENTIA,

5104
03:21:01,722 --> 03:21:04,792
DEMENTIA CARE, RESULTS IN

5105
03:21:04,792 --> 03:21:06,027
PRIORITIZED RECOMMENDATIONS AND

5106
03:21:06,027 --> 03:21:07,195
ULTIMATELY MILESTONES IN THE

5107
03:21:07,195 --> 03:21:10,064
CASE OF THE ADRD SUMMIT, FACA

5108
03:21:10,064 --> 03:21:13,768
MILESTONES IN THE NATIONAL PLAN.

5109
03:21:13,768 --> 03:21:18,139
AND THOSE MILESTONES ARE

5110
03:21:18,139 --> 03:21:19,006
SCIENTIFICALLY, WE HOPE, DRIVE

5111
03:21:19,006 --> 03:21:22,844
TOWARD THE GOAL OF THE NATIONAL

5112
03:21:22,844 --> 03:21:23,377
PLAN.

5113
03:21:23,377 --> 03:21:24,812
NIA LEADS THE OVERALL NIH

5114
03:21:24,812 --> 03:21:26,247
RESPONSE TO THE NATIONAL PLAN TO

5115
03:21:26,247 --> 03:21:27,014
ADDRESS ALZHEIMER'S DISEASE

5116
03:21:27,014 --> 03:21:29,016
WHICH IS REALLY THE NATIONAL

5117
03:21:29,016 --> 03:21:31,652
PLAN TO ADDRESS ALZHEIMER'S

5118
03:21:31,652 --> 03:21:33,721
DISEASE AND RELATED DEMENTIAS.

5119
03:21:33,721 --> 03:21:36,324
THE NINDS AND NIA COLLABORATE

5120
03:21:36,324 --> 03:21:39,193
CLOSELY TOGETHER ON FUNDING

5121
03:21:39,193 --> 03:21:42,463
OPPORTUNITIES, PAYLINES,

5122
03:21:42,463 --> 03:21:42,697
SUMMITS.

5123
03:21:42,697 --> 03:21:49,470
THE NINDS LEADS LEWY BODY

5124
03:21:49,470 --> 03:21:50,838
DEMENTIA, FRONTOTEMPORAL,

5125
03:21:50,838 --> 03:21:52,206
SIGNIFICANT INCREASES IN

5126
03:21:52,206 --> 03:21:56,344
RESOURCES AVAILABLE FOR THESE

5127
03:21:56,344 --> 03:21:58,312
OVER THE YEARS.

5128
03:21:58,312 --> 03:22:02,049
AND THE LAST SUMMIT THAT THE

5129
03:22:02,049 --> 03:22:04,986
NINDS LED ON ADRD WAS 2022,

5130
03:22:04,986 --> 03:22:08,723
ANOTHER ONE IN 2025.

5131
03:22:08,723 --> 03:22:09,690
AMBER McCARTNEY IS PROJECT

5132
03:22:09,690 --> 03:22:12,793
MANAGER, THE LEAD OF THE THAT

5133
03:22:12,793 --> 03:22:14,061
SUMMIT, THE PROGRAM LEAD.

5134
03:22:14,061 --> 03:22:16,697
THERE WILL BE A SCIENTIFIC CHAIR

5135
03:22:16,697 --> 03:22:18,666
DETERMINED AT LATER TIME.

5136
03:22:18,666 --> 03:22:20,635
YOU'LL HEAR MORE AT ANOTHER

5137
03:22:20,635 --> 03:22:25,773
COUNCIL MEETING.

5138
03:22:25,773 --> 03:22:26,874
SO, THE INITIATIVE CONCEPTS THAT

5139
03:22:26,874 --> 03:22:30,311
I'M GOING TO SHOW HERE ON TWO

5140
03:22:30,311 --> 03:22:33,514
SLIDES ARE BASED ON THE

5141
03:22:33,514 --> 03:22:35,416
MILESTONES THAT COME FROM THE

5142
03:22:35,416 --> 03:22:36,183
ADRD SUMMIT.

5143
03:22:36,183 --> 03:22:41,522
AND THEY ARE THE RESULT OF A

5144
03:22:41,522 --> 03:22:44,592
PROCESS THAT STARTED LAST JULY

5145
03:22:44,592 --> 03:22:50,531
INVOLVING MANY, MANY PROGRAM

5146
03:22:50,531 --> 03:22:52,500
DIRECTORS AND INPUT, FROM THE

5147
03:22:52,500 --> 03:22:54,869
NIA, INCLUDING DIRECTORS OF BOTH

5148
03:22:54,869 --> 03:22:55,169
INSTITUTES.

5149
03:22:55,169 --> 03:23:05,346
I WON'T GO OVER THESE INDIVIDUA.

5150
03:23:05,346 --> 03:23:09,016
DOCTORS BRODY AND IT WAS HANK

5151
03:23:09,016 --> 03:23:15,957
ALSO REVIEWED THESE ALREADY LAST

5152
03:23:15,957 --> 03:23:17,892
WEEK YOU'LL NOTICE A NUMBER ARE

5153
03:23:17,892 --> 03:23:18,392
REISSUES.

5154
03:23:18,392 --> 03:23:22,596
THERE ARE SOME THAT ARE NEW.

5155
03:23:22,596 --> 03:23:24,465
WE'VE BROKEN INTO CATEGORIES FOR

5156
03:23:24,465 --> 03:23:25,766
TRAINING AND CAREER DISEASE

5157
03:23:25,766 --> 03:23:27,201
MECHANISMS.

5158
03:23:27,201 --> 03:23:32,573
YOU SEE THE NAME OF THE PROGRAM 

5159
03:23:32,573 --> 03:23:33,341
DIRECTOR, PROJECT OFFICER, LAST

5160
03:23:33,341 --> 03:23:34,108
NIGHT ON THE RIGHT-HAND SIDE.

5161
03:23:34,108 --> 03:23:37,044
THIS IS THE FIRST OF TWO SLIDES

5162
03:23:37,044 --> 03:23:38,579
WITH CONCEPTS SO I'M GOING TO

5163
03:23:38,579 --> 03:23:42,416
PAUSE FOR A MOMENT.

5164
03:23:42,416 --> 03:23:43,551
THE PROGRAM DIRECTORS, CONTACTS,

5165
03:23:43,551 --> 03:23:44,518
ARE AVAILABLE TO TAKE QUESTIONS

5166
03:23:44,518 --> 03:23:46,153
SO I WILL PAUSE AND SEE IF THERE

5167
03:23:46,153 --> 03:23:54,562
ARE ANY QUESTIONS. 

5168
03:23:54,562 --> 03:23:56,497
 

5169
03:23:56,497 --> 03:23:58,299
I HAVE DAVE NODDING AT ME.

5170
03:23:58,299 --> 03:24:00,034
HEARING NONE, I'M GOING TO GO TO

5171
03:24:00,034 --> 03:24:06,073
THE NEXT SLIDE.

5172
03:24:06,073 --> 03:24:10,411
WE HAVE OUR CONCEPTS

5173
03:24:10,411 --> 03:24:11,212
TRANSLATION.

5174
03:24:11,212 --> 03:24:12,046
RESOURCES.

5175
03:24:12,046 --> 03:24:13,447
CLINICAL TRIALS.

5176
03:24:13,447 --> 03:24:16,050
AND CLINICAL RESEARCH.

5177
03:24:16,050 --> 03:24:17,451
AGAIN, THE PROGRAM DIRECTORS ARE

5178
03:24:17,451 --> 03:24:18,853
AVAILABLE TO ANSWER QUESTIONS

5179
03:24:18,853 --> 03:24:19,987
ABOUT THESE CONCEPTS.

5180
03:24:19,987 --> 03:24:22,189
SOME ARE NEW, SOME REISSUES.

5181
03:24:22,189 --> 03:24:24,191
AND SO I WILL ONCE AGAIN PAUSE

5182
03:24:24,191 --> 03:24:26,160
JUST FOR A FEW MOMENTS, SEE IF

5183
03:24:26,160 --> 03:24:27,061
ANYBODY WOULD LIKE TO ASK

5184
03:24:27,061 --> 03:24:29,230
QUESTIONS.

5185
03:24:29,230 --> 03:24:32,833
 

5186
03:24:32,833 --> 03:24:33,000
IS.

5187
03:24:33,000 --> 03:24:35,169
AND WAIT FOR DAVE TO NOD AT ME

5188
03:24:35,169 --> 03:24:36,237
AGAIN.

5189
03:24:36,237 --> 03:24:38,773
OKAY.

5190
03:24:38,773 --> 03:24:41,509
WELL, THANK YOU VERY MUCH FOR

5191
03:24:41,509 --> 03:24:42,843
THE OPPORTUNITY TO JUST SAY A

5192
03:24:42,843 --> 03:24:43,377
FEW WORDS.

5193
03:24:43,377 --> 03:24:46,380
AND I THINK I MIGHT BE THE LAST

5194
03:24:46,380 --> 03:24:47,648
THING HOLDING YOU UP TODAY.

5195
03:24:47,648 --> 03:24:49,383
I'LL STOP THERE.

5196
03:24:49,383 --> 03:24:53,788
>> NO, WE HAVE SO MUCH
MORE.

5197
03:24:53,788 --> 03:24:55,389
SO WHAT WE'LL DO NOW IF THERE

5198
03:24:55,389 --> 03:24:58,192
ARE NO QUESTIONS ON ANY OF THE

5199
03:24:58,192 --> 03:24:59,994
CONCEPTS, WE'LL ASK FOR A MOMENT

5200
03:24:59,994 --> 03:25:03,464
TO MOVE FORWARD WITH THOSE.

5201
03:25:03,464 --> 03:25:04,799
>> I MOVE WE MOVE FORWARD
WITH

5202
03:25:04,799 --> 03:25:07,001
THOSE. 

5203
03:25:07,001 --> 03:25:10,171
>> IS THERE A SECOND?

5204
03:25:10,171 --> 03:25:10,571
>> SECOND.

5205
03:25:10,571 --> 03:25:10,938
>> PERFECT.

5206
03:25:10,938 --> 03:25:13,874
SINCE THERE ARE QUITE A FEW I'LL

5207
03:25:13,874 --> 03:25:17,945
MAKE SURE YOU DO SCROLL TO THE

5208
03:25:17,945 --> 03:25:20,347
BOTTOM AND SELECT, YOU KNOW,

5209
03:25:20,347 --> 03:25:25,252
THERE'S 21 CONCEPTS FOR ADRD,

5210
03:25:25,252 --> 03:25:26,554
SELECT 100 SHOW IT SHOWS ALL OF

5211
03:25:26,554 --> 03:25:31,725
THEM AND VOTE. 

5212
03:25:31,725 --> 03:25:36,764
>> I'M PLEASED TO SEE MORE
LEWY

5213
03:25:36,764 --> 03:25:38,499
BODY-FOCUSED PLANS, THAT'S

5214
03:25:38,499 --> 03:25:39,233
EXCELLENT.

5215
03:25:39,233 --> 03:25:43,537
MORE ON THE RD PART OF THE ADRD,

5216
03:25:43,537 --> 03:25:45,840
THAT'S REALLY HELPFUL.

5217
03:25:45,840 --> 03:25:47,374
>> SO, AS WE'RE VOTING I
BELIEVE

5218
03:25:47,374 --> 03:25:49,577
WHAT WE'LL USE THAT TIME TO TEE

5219
03:25:49,577 --> 03:25:55,583
UP THE NEXT SESSION WHICH IS A

5220
03:25:55,583 --> 03:25:57,985
PRESENTATION OR INITIAL

5221
03:25:57,985 --> 03:26:00,721
DISCUSSION OF OUR 75th

5222
03:26:00,721 --> 03:26:03,324
ANNIVERSARY CELEBRATION.

5223
03:26:03,324 --> 03:26:09,163
ALYSSA GALLAGHER IS GOING TO LET

5224
03:26:09,163 --> 03:26:10,664
YOU KNOW ABOUT THAT.

5225
03:26:10,664 --> 03:26:13,534
>> CAN EVERYBODY HEAR ME
OKAY?

5226
03:26:13,534 --> 03:26:14,502
ALL RIGHT.

5227
03:26:14,502 --> 03:26:15,169
CONCEPTS APPROVED.

5228
03:26:15,169 --> 03:26:19,573
NOW WE'RE GOING TO PARTY.

5229
03:26:19,573 --> 03:26:21,308
SO IT'S WONDERFUL TO SEE ALL OF

5230
03:26:21,308 --> 03:26:21,575
YOU.

5231
03:26:21,575 --> 03:26:23,911
I WANT TO EXTEND A WARM WELCOME

5232
03:26:23,911 --> 03:26:27,681
TO THE NEW MEMBERS ON COUNCIL.

5233
03:26:27,681 --> 03:26:30,384
I'M DIRECTOR OF OFFICE OF

5234
03:26:30,384 --> 03:26:31,685
NEUROSCIENCE COMMUNICATIONS AND

5235
03:26:31,685 --> 03:26:36,290
ENGAGEMENT HERE AT NINDS, THE

5236
03:26:36,290 --> 03:26:37,658
COMMUNICATION SHOP.

5237
03:26:37,658 --> 03:26:46,567
I'M HAPPY TO KICK OFF THE YEAR 

5238
03:26:46,567 --> 03:26:50,271
ON A CELEBRATORY NOTE.

5239
03:26:50,271 --> 03:26:53,107
I'M GOING TO PROVIDE BACKGROUND

5240
03:26:53,107 --> 03:26:55,075
ON CELEBRATIONS AND BRING YOU UP

5241
03:26:55,075 --> 03:26:57,478
TO SPEED ON PLANNING EFFORTS

5242
03:26:57,478 --> 03:26:58,145
UNDERWAY.

5243
03:26:58,145 --> 03:27:00,681
WE'LL SHARE IDEAS OF ACTIVITIES

5244
03:27:00,681 --> 03:27:02,316
AND DIFFERENT EVENTS WE WANT TO

5245
03:27:02,316 --> 03:27:03,784
HOST THROUGHOUT THE YEAR AND

5246
03:27:03,784 --> 03:27:05,953
MOST IMPORTANTLY WANT TO GET

5247
03:27:05,953 --> 03:27:07,688
YOUR FEEDBACK AND REQUEST YOUR

5248
03:27:07,688 --> 03:27:11,525
SUPPORT AND PARTICIPATION FOR 

5249
03:27:11,525 --> 03:27:12,593
OUR CONTINUED PLANNING EFFORTS.

5250
03:27:12,593 --> 03:27:16,096
AS YOU CAN SEE ON THIS SLIDE, A

5251
03:27:16,096 --> 03:27:19,099
LITTLE BIT OF BACKGROUND, IN

5252
03:27:19,099 --> 03:27:21,702
1950 THE NATIONAL INSTITUTE OF

5253
03:27:21,702 --> 03:27:24,104
NEUROLOGICAL DISEASES AND

5254
03:27:24,104 --> 03:27:26,307
BLINDNESS WAS ESTABLISHED.

5255
03:27:26,307 --> 03:27:28,042
IN 1968 THE NAME CHANGED TO THE

5256
03:27:28,042 --> 03:27:31,645
NAME WE KNOW AND LOVE TODAY.

5257
03:27:31,645 --> 03:27:33,647
AND AS WALTER NOTED WE'LL BE

5258
03:27:33,647 --> 03:27:41,188
CELEBRATED OUR 75th NEXT YEAR.

5259
03:27:41,188 --> 03:27:45,092
NEXT SLIDE PLEASE. 

5260
03:27:45,092 --> 03:27:46,727
SO WHY DO WE CELEBRATE?

5261
03:27:46,727 --> 03:27:50,130
AGAIN, WE WANT TO HOST EVENTS TO

5262
03:27:50,130 --> 03:27:52,066
SHARE OUR RESEARCH PRIORITIES,

5263
03:27:52,066 --> 03:27:53,100
CELEBRATE ACCOMPLISHMENTS, SOME

5264
03:27:53,100 --> 03:27:54,868
OF THE MANY THAT YOU'VE ALREADY

5265
03:27:54,868 --> 03:27:56,237
HEARD TODAY THROUGH THE HEAL

5266
03:27:56,237 --> 03:27:58,906
INITIATIVE, AND THROUGH THE PAIN

5267
03:27:58,906 --> 03:27:59,707
RESEARCH PORTFOLIO.

5268
03:27:59,707 --> 03:28:03,811
TO IMAGINE THE FUTURE OF

5269
03:28:03,811 --> 03:28:04,845
NEUROSCIENCE WITH STRATEGIC

5270
03:28:04,845 --> 03:28:06,480
PARTNERS, AN IMPORTANT POINT AS

5271
03:28:06,480 --> 03:28:08,382
WE WANT TO LOOK BACK AND REFLECT

5272
03:28:08,382 --> 03:28:14,855
ON THE PAST, THE THE PREVIOUS

5273
03:28:14,855 --> 03:28:16,290
YEARS SINCE THE 50th AND 75

5274
03:28:16,290 --> 03:28:18,359
YEARS IN THE ENTIRETY BUT LOOK

5275
03:28:18,359 --> 03:28:19,893
TO THE FUTURE TOWARDS THAT WITH

5276
03:28:19,893 --> 03:28:23,731
ALL OF YOU BECAUSE AS WALTER 

5277
03:28:23,731 --> 03:28:24,732
MENTIONED EARLIER A LOT OF WORK

5278
03:28:24,732 --> 03:28:26,333
STILL NEEDS TO BE DONE.

5279
03:28:26,333 --> 03:28:28,836
WE WANT TO PUT THE FOCUS AND

5280
03:28:28,836 --> 03:28:35,409
EMPHASIS ON IMAGINING THE FUTURE

5281
03:28:35,409 --> 03:28:37,511
OF NEUROSCIENCE.

5282
03:28:37,511 --> 03:28:40,047
THIS WILL BROADEN NETWORKS,

5283
03:28:40,047 --> 03:28:40,981
INCREASE COLLABORATION

5284
03:28:40,981 --> 03:28:41,882
OPPORTUNITIES AND HOPEFULLY ABLE

5285
03:28:41,882 --> 03:28:44,752
TO BEGIN RESTORING SOME OF THAT

5286
03:28:44,752 --> 03:28:47,154
PUBLIC TRUST AND TRUST IN

5287
03:28:47,154 --> 03:28:48,188
INSTITUTIONS THAT HAS BEEN

5288
03:28:48,188 --> 03:28:50,991
DETERIORATING FOR A WHILE NOW.

5289
03:28:50,991 --> 03:28:53,160
FINALLY WE WANT TO CREATE

5290
03:28:53,160 --> 03:28:55,896
DURABLE RESOURCES THAT WILL LAST

5291
03:28:55,896 --> 03:28:57,197
BEYOND OBSERVANCE, MINDFUL OF

5292
03:28:57,197 --> 03:28:58,198
THE BUDGET SITUATION SO ANYTHING

5293
03:28:58,198 --> 03:29:01,368
WE'RE GOING TO BE PUTTING STAFF

5294
03:29:01,368 --> 03:29:03,804
TIME, RESOURCES, MONEY TOWARDS

5295
03:29:03,804 --> 03:29:05,306
WE WANT IT TO GO INTO THE FUTURE

5296
03:29:05,306 --> 03:29:10,244
AND WE ALSO WANT TO BE ABLE TO

5297
03:29:10,244 --> 03:29:12,146
LEVERAGE EXISTING RESOURCES,

5298
03:29:12,146 --> 03:29:13,080
INCREDIBLY AMAZING AND CREATIVE

5299
03:29:13,080 --> 03:29:16,250
STAFF THAT CAN WORK ON SOME OF

5300
03:29:16,250 --> 03:29:17,985
THESE ACTIVITIES, EVENTS, AND

5301
03:29:17,985 --> 03:29:18,352
MATERIALS.

5302
03:29:18,352 --> 03:29:19,486
AND ALSO OUR CONTRACT SUPPORT,

5303
03:29:19,486 --> 03:29:24,458
WE WANT TO BE ABLE TO LEVERAGE

5304
03:29:24,458 --> 03:29:26,393
MECHANISMS TO PAY FOR SOME OF

5305
03:29:26,393 --> 03:29:27,094
THESE THINGS AS WELL.

5306
03:29:27,094 --> 03:29:28,062
IT WAS BROUGHT TO OUR ATTENTION

5307
03:29:28,062 --> 03:29:31,799
BY SOMEONE ON THE PLANNING

5308
03:29:31,799 --> 03:29:34,201
COMMITTEE THAT IN TRADITIONAL

5309
03:29:34,201 --> 03:29:35,402
ANNIVERSARY CELEBRATIONS, THE

5310
03:29:35,402 --> 03:29:37,271
GIFT IS A DIAMOND.

5311
03:29:37,271 --> 03:29:38,038
I WAS JOKING WITH FOLKS WE'RE

5312
03:29:38,038 --> 03:29:40,908
NOT GOING TO BE GIVING EVERYBODY

5313
03:29:40,908 --> 03:29:42,543
DIAMOND EARRINGS FOR THE

5314
03:29:42,543 --> 03:29:43,844
ANNIVERSARY BUT YOU COULD

5315
03:29:43,844 --> 03:29:50,184
IMAGINE SOME SORT OF CREATIVE

5316
03:29:50,184 --> 03:29:51,018
CRYSTAL-FACETED BRAIN GRAPHIC OR

5317
03:29:51,018 --> 03:29:54,455
LOGO ASSOCIATED WITH ALL OF OUR

5318
03:29:54,455 --> 03:29:55,556
ACTIVITIES, MATERIALS, AND

5319
03:29:55,556 --> 03:29:55,889
EVENTS.

5320
03:29:55,889 --> 03:29:59,159
HERE ARE SOME OTHER LOGOS FOR

5321
03:29:59,159 --> 03:30:01,662
OTHER INSTITUTES THAT HAVE

5322
03:30:01,662 --> 03:30:02,963
CELEBRATED RECENTLY.

5323
03:30:02,963 --> 03:30:04,965
KIND OF BLAND, I'M EXCITED TO

5324
03:30:04,965 --> 03:30:10,437
INCORPORATE SOME SPARKLE INTO

5325
03:30:10,437 --> 03:30:12,940
OURS. 

5326
03:30:12,940 --> 03:30:13,607
EVERY INSTITUTE CELEBRATING WILL

5327
03:30:13,607 --> 03:30:18,512
COME UP WITH A GRAPHIC DESIGN

5328
03:30:18,512 --> 03:30:21,315
FOR THEIR CELEBRATION.

5329
03:30:21,315 --> 03:30:24,151
SO, AS FAR AS BRANDING AND

5330
03:30:24,151 --> 03:30:26,153
DIGITAL CONTENT WE'LL BE REALLY

5331
03:30:26,153 --> 03:30:28,922
INVOLVED IN WORKING ACROSS OUR

5332
03:30:28,922 --> 03:30:31,091
OFFICE, AND ACROSS INSTITUTE, TO

5333
03:30:31,091 --> 03:30:32,292
REALLY CREATE A LARGE

5334
03:30:32,292 --> 03:30:34,161
ANNIVERSARY PRESENCE ON OUR

5335
03:30:34,161 --> 03:30:36,563
WEBSITE, THAT WILL INCLUDE

5336
03:30:36,563 --> 03:30:39,533
HIGHLIGHTS AND TIMELINES AND

5337
03:30:39,533 --> 03:30:41,702
OTHER INTERACTIVE FEATURES.

5338
03:30:41,702 --> 03:30:43,470
WE'RE ALREADY DISCUSSING

5339
03:30:43,470 --> 03:30:45,205
DEVELOPING A COMMEMORATIVE

5340
03:30:45,205 --> 03:30:46,340
VIDEO.

5341
03:30:46,340 --> 03:30:48,475
WE WERE REALLY JAZZED ABOUT

5342
03:30:48,475 --> 03:30:49,877
NIMH'S VIDEO FOR THEIR

5343
03:30:49,877 --> 03:30:51,211
ANNIVERSARY WHICH THEY ARE STILL

5344
03:30:51,211 --> 03:30:53,180
CELEBRATING NOW.

5345
03:30:53,180 --> 03:30:55,482
THEY DID A QUICK 75 YEARS IN 75

5346
03:30:55,482 --> 03:30:57,017
SECONDS, ALL OF YOU CAN

5347
03:30:57,017 --> 03:30:58,886
APPRECIATE THAT THAT'S ABOUT THE

5348
03:30:58,886 --> 03:31:01,822
ATTENTION SPAN WE'RE WORKING

5349
03:31:01,822 --> 03:31:03,791
WITH THESE DAYS.

5350
03:31:03,791 --> 03:31:04,758
SO EPIC HISTORICAL DOCUMENTARY

5351
03:31:04,758 --> 03:31:06,160
IS NOT IN THE FUTURE BUT

5352
03:31:06,160 --> 03:31:08,996
SOMETHING LIKE THIS WOULD BE 

5353
03:31:08,996 --> 03:31:18,372
PRETTY FUN TO DO. 

5354
03:31:18,372 --> 03:31:20,908
THE OFFICE OF NIH, PROFILES OF

5355
03:31:20,908 --> 03:31:22,009
RESEARCHERS OVER THE YEARS,

5356
03:31:22,009 --> 03:31:26,146
WE'VE BEEN TAPPING INTO THEM TO

5357
03:31:26,146 --> 03:31:29,883
GET OLD PHOTOS AND TELL STORIES

5358
03:31:29,883 --> 03:31:31,452
OF THE AMAZING RESEARCHERS THAT

5359
03:31:31,452 --> 03:31:33,520
HAVE COME BEFORE US.

5360
03:31:33,520 --> 03:31:35,189
AND CERTAINLY MY OFFICE AND

5361
03:31:35,189 --> 03:31:37,124
FOLKS ACROSS THE INSTITUTE WILL

5362
03:31:37,124 --> 03:31:40,427
BE INVOLVED IN DEVELOPING AND

5363
03:31:40,427 --> 03:31:43,063
DISTRIBUTING ADDITIONAL OUTREACH

5364
03:31:43,063 --> 03:31:43,931
MATERIALS INCLUDING DIGITAL

5365
03:31:43,931 --> 03:31:47,100
TOOLKITS, WE'RE HOPING TO BUILD

5366
03:31:47,100 --> 03:31:48,635
A DIGITAL STORYTELLING PLATFORM

5367
03:31:48,635 --> 03:31:50,370
WHERE WE COULD INCORPORATE, YOU

5368
03:31:50,370 --> 03:31:53,540
KNOW, ALL DIFFERENT KINDS OF

5369
03:31:53,540 --> 03:31:55,642
MULTIMEDIA, INCLUDING AUDIO

5370
03:31:55,642 --> 03:31:57,411
CLIPS, VIDEO, IMAGERY TO REALLY

5371
03:31:57,411 --> 03:31:58,912
TELL LONGER FORM STORIES ABOUT

5372
03:31:58,912 --> 03:32:00,481
THE IMPACT OF OUR RESEARCH AND

5373
03:32:00,481 --> 03:32:08,655
HOW WE GOT TO WHERE WE ARE.

5374
03:32:08,655 --> 03:32:09,957
NEXT SLIDE PLEASE.

5375
03:32:09,957 --> 03:32:11,058
AGAIN MORE MATERIALS THAT ARE

5376
03:32:11,058 --> 03:32:14,461
COMMON WHEN ANNIVERSARIES COME

5377
03:32:14,461 --> 03:32:21,335
UP, COMMEMORATIVE BOOKLET, YOU 

5378
03:32:21,335 --> 03:32:23,537
SAW THE 50th, THINKING ABOUT

5379
03:32:23,537 --> 03:32:24,972
SUBMITTING A SCIENTIFIC JOURNAL

5380
03:32:24,972 --> 03:32:26,306
ARTICLE.

5381
03:32:26,306 --> 03:32:28,442
FOR THOSE COMING ON CAMPUS NEXT

5382
03:32:28,442 --> 03:32:29,776
YEAR FOR SOME CELEBRATIONS

5383
03:32:29,776 --> 03:32:31,979
YOU'LL SEE BANNERS AROUND CAMPUS

5384
03:32:31,979 --> 03:32:34,381
ON THE LAMP POSTS.

5385
03:32:34,381 --> 03:32:38,085
WE'LL PLAN TO ADD THE 75th

5386
03:32:38,085 --> 03:32:41,355
ANNIVERSARY LOGO TO ALL OF OUR

5387
03:32:41,355 --> 03:32:42,189
OUTREACH MATERIALS,

5388
03:32:42,189 --> 03:32:43,423
PUBLICATIONS, AND EXHIBITS.

5389
03:32:43,423 --> 03:32:45,425
AND THEN WE'RE THINKING ABOUT

5390
03:32:45,425 --> 03:32:47,594
WAYS TO REALLY LEVERAGE THE

5391
03:32:47,594 --> 03:32:50,564
ACTIVITIES THAT WE DO ANNUALLY

5392
03:32:50,564 --> 03:32:52,933
BY HIGHLIGHTING, YOU KNOW, THESE

5393
03:32:52,933 --> 03:32:55,035
MILESTONES, THE BRAIN INITIATIVE

5394
03:32:55,035 --> 03:32:58,805
TURN 10 THIS YEAR, 75 NEXT YEAR,

5395
03:32:58,805 --> 03:33:02,743
MAYBE A SHOW US YOUR BRAIN

5396
03:33:02,743 --> 03:33:08,015
CONTEST, CAN HIGHLIGHT AND

5397
03:33:08,015 --> 03:33:09,750
CELEBRATE MILESTONES TOGETHER.

5398
03:33:09,750 --> 03:33:11,818
THERE'S A LOT OF WAYS WE'RE

5399
03:33:11,818 --> 03:33:13,687
THINKING ABOUT DOING THIS.

5400
03:33:13,687 --> 03:33:18,158
THIS GIVES A BREAKDOWN OF THE

5401
03:33:18,158 --> 03:33:19,159
BUCKETS OF EVENTS AND

5402
03:33:19,159 --> 03:33:20,827
ACTIVITIES, AND OPPORTUNITIES

5403
03:33:20,827 --> 03:33:22,963
THAT WE FORESEE COMING UP OVER

5404
03:33:22,963 --> 03:33:26,300
THE NEXT YEAR, YEAR AND A HALF.

5405
03:33:26,300 --> 03:33:28,035
ONE OF THE THINGS THAT WE'RE

5406
03:33:28,035 --> 03:33:29,670
PRETTY EXCITED ABOUT IS HOSTING

5407
03:33:29,670 --> 03:33:32,406
A NINDS DAY AT NIH.

5408
03:33:32,406 --> 03:33:36,143
EITHER IN AUGUST, SORT OF

5409
03:33:36,143 --> 03:33:38,946
THINKING IN AUGUST, THE DATE OF

5410
03:33:38,946 --> 03:33:39,713
OUR OFFICIAL ANNIVERSARY, DO WE

5411
03:33:39,713 --> 03:33:42,182
WANT TO PUSH IT OFF TO

5412
03:33:42,182 --> 03:33:43,550
SEPTEMBER, CLOSE TO THE COUNCIL

5413
03:33:43,550 --> 03:33:45,185
MEETING WHERE YOU WILL ALREADY

5414
03:33:45,185 --> 03:33:47,120
BE HERE SO WE'RE JUST TRYING TO

5415
03:33:47,120 --> 03:33:49,923
FIGURE OUT THE RIGHT TIMING FOR

5416
03:33:49,923 --> 03:33:50,223
THAT.

5417
03:33:50,223 --> 03:33:52,993
IT WILL DEPEND ON SPACE

5418
03:33:52,993 --> 03:33:56,263
AVAILABLE ON CAMPUS BECAUSE HOW

5419
03:33:56,263 --> 03:33:59,333
WE ENVISION THIS, HEAD OVER TO,

5420
03:33:59,333 --> 03:34:02,069
YOU KNOW, THE INTRAMURAL

5421
03:34:02,069 --> 03:34:02,936
PROGRAM, DIFFERENT LABS, PORTER

5422
03:34:02,936 --> 03:34:05,539
BUILDING, TO HAVE A SERIES OF

5423
03:34:05,539 --> 03:34:07,574
CHATS OR LAB TOURS, WE MIGHT DO

5424
03:34:07,574 --> 03:34:10,911
A PRESENTATION AT THE CLINICAL

5425
03:34:10,911 --> 03:34:11,912
CENTER THAT HIGHLIGHTS

5426
03:34:11,912 --> 03:34:13,880
BREAKTHROUGHS AND ROUND IT OUT

5427
03:34:13,880 --> 03:34:17,951
WITH A CAPSTONE EVENT OR

5428
03:34:17,951 --> 03:34:19,152
SYMPOSIUM AT NATCHER.

5429
03:34:19,152 --> 03:34:23,523
REALLY UTILIZING ALL THE SPACES

5430
03:34:23,523 --> 03:34:27,594
ON CAMPUS, AND JUST HAVING A BIG

5431
03:34:27,594 --> 03:34:27,928
DAY.

5432
03:34:27,928 --> 03:34:31,198
WE'RE ALSO THINKING ABOUT A

5433
03:34:31,198 --> 03:34:33,467
SERIES OF NINDS SCIENTIFIC

5434
03:34:33,467 --> 03:34:34,368
SYMPOSIA OR WORKSHOPS ON

5435
03:34:34,368 --> 03:34:36,169
IMAGINING THE FUTURE OF

5436
03:34:36,169 --> 03:34:37,537
NEUROSCIENCE, ALREADY GEARING UP

5437
03:34:37,537 --> 03:34:40,707
FOR THE NEXT VERSION OF OUR

5438
03:34:40,707 --> 03:34:42,442
STRATEGIC PLANNING PROCESS FOR

5439
03:34:42,442 --> 03:34:43,510
THE INSTITUTE.

5440
03:34:43,510 --> 03:34:46,713
SO POSSIBLY USING SOME OF THESE

5441
03:34:46,713 --> 03:34:48,915
SESSIONS TO HELP INFORM THOSE

5442
03:34:48,915 --> 03:34:50,384
INITIAL DISCUSSIONS AND PLANNING

5443
03:34:50,384 --> 03:34:53,186
EFFORTS, ONE OF THE VISIONS THAT

5444
03:34:53,186 --> 03:34:54,154
WE HAVE.

5445
03:34:54,154 --> 03:35:00,727
WE ATTEND A LOT OF ANNUAL

5446
03:35:00,727 --> 03:35:03,930
CONFERENCES MEETINGS, FORUMS, 

5447
03:35:03,930 --> 03:35:05,599
STAFF ARE PRESENTING ALL THE

5448
03:35:05,599 --> 03:35:07,601
TIME, EXHIBITING AT LARGE

5449
03:35:07,601 --> 03:35:09,703
CONFERENCES, HOW DO WE USE THOSE

5450
03:35:09,703 --> 03:35:11,772
EVENTS ALREADY EMBEDDED INTO OUR

5451
03:35:11,772 --> 03:35:15,175
SCHEDULES TO HAVE SOME, YOU

5452
03:35:15,175 --> 03:35:16,376
KNOW, CONVERSATIONS AND AGAIN

5453
03:35:16,376 --> 03:35:22,716
HIGHLIGHT SOME OF THE  SUCCESSES

5454
03:35:22,716 --> 03:35:25,452
OVER THE PAST 25 YEARS.

5455
03:35:25,452 --> 03:35:27,421
WE'RE INTERESTED ON GOING ON A

5456
03:35:27,421 --> 03:35:34,327
ROAD  TRIP TO HIGHLIGHT, IF

5457
03:35:34,327 --> 03:35:38,732
ANYBODY IS INTERESTED IN

5458
03:35:38,732 --> 03:35:41,234
HOSTING, WE'D BE APPRECIATIVE, A

5459
03:35:41,234 --> 03:35:42,002
PANEL, FIRESIDE CHAT, ENVISION

5460
03:35:42,002 --> 03:35:43,970
WHAT THAT MIGHT LOOK LIKE.

5461
03:35:43,970 --> 03:35:48,141
I WANTED TO DROP IN THE GENERAL

5462
03:35:48,141 --> 03:35:48,809
COMMUNICATIONS IN-BOX, OUR

5463
03:35:48,809 --> 03:35:50,610
ADDRESS FOR YOUR IDEAS ANDFULLY

5464
03:35:50,610 --> 03:35:52,345
INPUT, CERTAINLY IF WE HAVE A

5465
03:35:52,345 --> 03:35:54,815
COUPLE MINUTES, I KNOW WE'RE

5466
03:35:54,815 --> 03:35:57,751
RUNNING BEHIND NOW, WE WELCOME 

5467
03:35:57,751 --> 03:35:59,553
THOSE TODAY AS WELL.

5468
03:35:59,553 --> 03:36:01,521
AGAIN, WE HOPE YOU'LL JOIN THE

5469
03:36:01,521 --> 03:36:02,289
CELEBRATION.

5470
03:36:02,289 --> 03:36:03,724
WE KNOW YOU WILL.

5471
03:36:03,724 --> 03:36:06,359
BUT YOU CAN JOIN US FOR

5472
03:36:06,359 --> 03:36:07,327
BRAINSTORMING AND PLANNING

5473
03:36:07,327 --> 03:36:07,928
DISCUSSIONS.

5474
03:36:07,928 --> 03:36:10,297
YOU CAN JOIN US AT A SCIENTIFIC

5475
03:36:10,297 --> 03:36:12,232
SYMPOSIUM OR ROAD SHOW OR HOST A

5476
03:36:12,232 --> 03:36:13,333
ROAD SHOW.

5477
03:36:13,333 --> 03:36:18,171
AND WE WOULD REALLY HOPE YOU 

5478
03:36:18,171 --> 03:36:21,341
WOULD JOIN US FOR THE NINDS NIH

5479
03:36:21,341 --> 03:36:22,776
DAY CELEBRATION, IF IT WORKS FOR

5480
03:36:22,776 --> 03:36:23,510
YOU.

5481
03:36:23,510 --> 03:36:25,612
THIS IS HOW WE ARE STRUCTURING

5482
03:36:25,612 --> 03:36:27,347
THE WORK IN CASE ANY

5483
03:36:27,347 --> 03:36:29,449
SUBCOMMITTEES ARE INTERESTING TO

5484
03:36:29,449 --> 03:36:31,284
YOU.

5485
03:36:31,284 --> 03:36:33,587
WE'RE LOOKING FOR ALUMNI COUNCIL

5486
03:36:33,587 --> 03:36:35,222
MEMBERS, MAYBE EVEN PEOPLE WITH

5487
03:36:35,222 --> 03:36:36,556
LIVED EXPERIENCE TO JOIN, HELP

5488
03:36:36,556 --> 03:36:41,128
US PLAN SOME OF THESE EVENTS.

5489
03:36:41,128 --> 03:36:42,596
WE'VE ORGANIZED IT AROUND THE

5490
03:36:42,596 --> 03:36:44,331
BUCKETS I TALKED ABOUT,

5491
03:36:44,331 --> 03:36:45,632
COMMUNICATION AND OUTREACH

5492
03:36:45,632 --> 03:36:47,033
SUBCOMMITTEE, WE'LL HAVE

5493
03:36:47,033 --> 03:36:49,669
SUBCOMMITTEE FOCUSED ON PLANNING

5494
03:36:49,669 --> 03:36:51,104
NINDS DAY EVENTS.

5495
03:36:51,104 --> 03:36:55,342
WE'LL HAVE A STAFF ENGAGEMENT

5496
03:36:55,342 --> 03:36:57,310
CELEBRATION COMMITTEE WHICH IS

5497
03:36:57,310 --> 03:36:59,212
MORE TOWARD INTERNAL SIDE,

5498
03:36:59,212 --> 03:37:00,447
LOOKING AT HOW STAFF ARE

5499
03:37:00,447 --> 03:37:02,149
CONTRIBUTING TO THE MISSION AND

5500
03:37:02,149 --> 03:37:03,350
WHAT MAKES PEOPLE EXCITED TO GET

5501
03:37:03,350 --> 03:37:05,452
OUT OF BED AND COME TO WORK IN

5502
03:37:05,452 --> 03:37:06,319
THE MORNING.

5503
03:37:06,319 --> 03:37:10,690
AND THEN OF COURSE THE 

5504
03:37:10,690 --> 03:37:13,426
SCIENTIFIC SYMPOSIA, TRYING TO

5505
03:37:13,426 --> 03:37:15,061
IDENTIFY STRATEGY AND FORMAT,

5506
03:37:15,061 --> 03:37:16,797
WHAT CRITICAL TOPICS WE WANT TO

5507
03:37:16,797 --> 03:37:19,266
PRESENT ON. 

5508
03:37:19,266 --> 03:37:21,034
SO WITH THAT, I WILL THANK YOU

5509
03:37:21,034 --> 03:37:23,537
ALL FOR YOUR TIME AND IF THERE'S

5510
03:37:23,537 --> 03:37:25,639
ANY IDEAS OR DISCUSSION OR

5511
03:37:25,639 --> 03:37:27,040
QUESTIONS YOU HAVE NOW, I'M HERE

5512
03:37:27,040 --> 03:37:29,342
AND I KNOW WALTER IS HERE, VERY

5513
03:37:29,342 --> 03:37:31,111
INVESTED IN THIS.

5514
03:37:31,111 --> 03:37:38,485
HAPPY TO DISCUSS. 

5515
03:37:38,485 --> 03:37:40,120
>> THANK YOU.

5516
03:37:40,120 --> 03:37:42,956
TO ME, WHAT RESONATED MOST IS

5517
03:37:42,956 --> 03:37:44,591
RESTORING PUBLIC TRUST, ON ALL

5518
03:37:44,591 --> 03:37:46,426
OUR MINDS I THINK ALL THE TIME.

5519
03:37:46,426 --> 03:37:48,762
ONE THING I DON'T KNOW IF YOU

5520
03:37:48,762 --> 03:37:53,600
HAVE THOUGHT OF IT BUT ONE OF

5521
03:37:53,600 --> 03:37:54,467
THE PLACES, UNLESS THEY HAPPEN

5522
03:37:54,467 --> 03:37:55,902
TO BE SICK AND INVOLVED WITH

5523
03:37:55,902 --> 03:37:58,071
NIH, THEY ARE NOT GOING TO KNOW

5524
03:37:58,071 --> 03:37:58,371
ABOUT IT.

5525
03:37:58,371 --> 03:38:01,374
BUT ONE PLACE THEY DO SHOW UP

5526
03:38:01,374 --> 03:38:02,976
ARE MUSEUMS.

5527
03:38:02,976 --> 03:38:04,544
AND SO SCIENCE MUSEUMS, THIS

5528
03:38:04,544 --> 03:38:05,946
WOULD SEEM LIKE A FANTASTIC

5529
03:38:05,946 --> 03:38:08,582
OPPORTUNITY TO SOMEHOW CREATE A

5530
03:38:08,582 --> 03:38:11,985
TRAVELING EXHIBIT THAT WOULD GET

5531
03:38:11,985 --> 03:38:13,486
BUY-IN FROM OTHER SCIENTISTS

5532
03:38:13,486 --> 03:38:15,055
MUSEUMS IN OTHER CITIES.

5533
03:38:15,055 --> 03:38:19,092
JUST TO HIGHLIGHT WHAT

5534
03:38:19,092 --> 03:38:20,627
NEUROSCIENCE IS AND WHAT

5535
03:38:20,627 --> 03:38:24,197
ACCOMPLISHMENTS HAVE BEEN MADE,

5536
03:38:24,197 --> 03:38:26,099
THAT WOULD ARE RESONATE AND

5537
03:38:26,099 --> 03:38:32,772
ENGAGE PEOPLE JUST LOOKING AT 

5538
03:38:32,772 --> 03:38:33,974
DINOSAURS, FOR EXAMPLE,

5539
03:38:33,974 --> 03:38:34,574
LITERALLY.

5540
03:38:34,574 --> 03:38:35,041
>> GREAT IDEA.

5541
03:38:35,041 --> 03:38:38,011
OTHER I.C.s HAVE DONE JUST

5542
03:38:38,011 --> 03:38:38,311
THAT.

5543
03:38:38,311 --> 03:38:40,747
EXHIBITS AT AIRPORTS ALSO WHICH

5544
03:38:40,747 --> 03:38:42,182
IS REALLY INTERESTING.

5545
03:38:42,182 --> 03:38:44,050
SOMEWHERE, WHERE YOU CAN GET OUT

5546
03:38:44,050 --> 03:38:47,187
AND CAPTURE THE PUBLIC'S

5547
03:38:47,187 --> 03:38:47,487
IMAGINATION.

5548
03:38:47,487 --> 03:38:49,155
AND REALLY SHARE WHAT WE'RE

5549
03:38:49,155 --> 03:38:50,724
DOING IN THE MISSION BECAUSE

5550
03:38:50,724 --> 03:38:51,892
LIKE YOU SAID UNLESS YOU'RE SICK

5551
03:38:51,892 --> 03:38:54,561
OR YOU HAVE A LOVED ONE

5552
03:38:54,561 --> 03:38:57,197
STRUGGLING WITH A DISORDER OR

5553
03:38:57,197 --> 03:38:59,099
YOU'RE IN SCIENTIFIC COMMUNITY,

5554
03:38:59,099 --> 03:39:00,834
YOU PROBABLY DON'T KNOW ALL THE

5555
03:39:00,834 --> 03:39:02,002
GREAT THINGS THAT WE DO.

5556
03:39:02,002 --> 03:39:03,436
THANK YOU, TIM.

5557
03:39:03,436 --> 03:39:05,038
THAT'S A GREAT SUGGESTION.

5558
03:39:05,038 --> 03:39:07,274
>> I WAS GOING TO SAY THE
SAME

5559
03:39:07,274 --> 03:39:08,808
THING, WHICH IS THE LAST TWO

5560
03:39:08,808 --> 03:39:12,312
POINTS OF WHY WE'RE DOING THIS,

5561
03:39:12,312 --> 03:39:14,047
THAT YOU MENTIONED, ABSOLUTELY

5562
03:39:14,047 --> 03:39:15,482
RESTORING PUBLIC TRUST, I CAN'T

5563
03:39:15,482 --> 03:39:17,651
REMEMBER THE LAST ONE, BUT THAT

5564
03:39:17,651 --> 03:39:21,488
WAS SUPER IMPORTANT.

5565
03:39:21,488 --> 03:39:24,557
AND I THINK THAT TIM IS SPOT ON,

5566
03:39:24,557 --> 03:39:26,059
PUBLIC OUTREACH.

5567
03:39:26,059 --> 03:39:27,260
BESIDES MUSEUMS AND AIRPORTS, A

5568
03:39:27,260 --> 03:39:29,362
GREAT WAY TO GET PEOPLE IS

5569
03:39:29,362 --> 03:39:30,463
THROUGH THE INTERNET.

5570
03:39:30,463 --> 03:39:34,834
YOU KNOW, MAYBE SOME SORT OF, I

5571
03:39:34,834 --> 03:39:37,671
DON'T KNOW, TIKTOK CAMPAIGN.

5572
03:39:37,671 --> 03:39:39,639
INTERACTIVE, PEOPLE COULD

5573
03:39:39,639 --> 03:39:40,407
CONTRIBUTE TO THE SCIENCE THE

5574
03:39:40,407 --> 03:39:43,043
NINDS DOES AND FEEL LIKE IT'S

5575
03:39:43,043 --> 03:39:46,079
NOT JUST THEM LEARNING SOMETHING

5576
03:39:46,079 --> 03:39:47,747
BUT ALSO US GETTING A CHANCE TO

5577
03:39:47,747 --> 03:39:50,250
LEARN SOMETHING FROM THE PUBLIC

5578
03:39:50,250 --> 03:39:57,357
THAT ENGAGES, THAT WOULD BE A

5579
03:39:57,357 --> 03:39:58,792
GREAT OPPORTUNITY.

5580
03:39:58,792 --> 03:39:59,759
>> GREAT IDEA.

5581
03:39:59,759 --> 03:39:59,926
AMY?

5582
03:39:59,926 --> 03:40:01,561
>> FIRST, THANK YOU FOR
THIS.

5583
03:40:01,561 --> 03:40:04,831
THIS IS EXCITING AND FUN AND

5584
03:40:04,831 --> 03:40:06,066
ABSOLUTELY A MILESTONE TO

5585
03:40:06,066 --> 03:40:07,000
CELEBRATE.

5586
03:40:07,000 --> 03:40:10,070
APPRECIATE THE REPORT.

5587
03:40:10,070 --> 03:40:13,940
I WANTED TO ECHO WHAT EVERYONE

5588
03:40:13,940 --> 03:40:15,008
IS SAYING, ESPECIALLY FLORIAN'S

5589
03:40:15,008 --> 03:40:16,676
COMMENTS IN THE CHAT ENGAGING

5590
03:40:16,676 --> 03:40:17,444
WITH PATIENTS.

5591
03:40:17,444 --> 03:40:19,713
ESPECIALLY JUST TO BRING OUT THE

5592
03:40:19,713 --> 03:40:22,248
PERSPECTIVE OF PATIENT ADVOCACY

5593
03:40:22,248 --> 03:40:22,582
ORGANIZATIONS.

5594
03:40:22,582 --> 03:40:24,317
A LOT OF PATIENT ORGANIZATIONS

5595
03:40:24,317 --> 03:40:25,986
WANT TO ENGAGE WITH NINDS BUT

5596
03:40:25,986 --> 03:40:27,153
DON'T KNOW HOW.

5597
03:40:27,153 --> 03:40:29,356
AND THIS WOULD BE A GREAT

5598
03:40:29,356 --> 03:40:31,458
INTRODUCTORY WAY TO ENGAGE WITH

5599
03:40:31,458 --> 03:40:37,998
THEM IN A BENIGN CELEBRATORY

5600
03:40:37,998 --> 03:40:38,231
WAY.

5601
03:40:38,231 --> 03:40:39,532
IT COULD HELP FURTHER

5602
03:40:39,532 --> 03:40:40,467
RELATIONSHIPS, THERE COULD BE

5603
03:40:40,467 --> 03:40:43,937
SOME NICE WINS DOWN THE ROAD,

5604
03:40:43,937 --> 03:40:45,572
ESPECIALLY IF PATIENT ADVOCACY

5605
03:40:45,572 --> 03:40:46,473
ORGANIZATIONS PLAY A HUGE ROLE

5606
03:40:46,473 --> 03:40:48,975
IN THE FUTURE OF NEUROSCIENCE,

5607
03:40:48,975 --> 03:40:52,612
SO I WOULD REALLY ENCOURAGE YOU

5608
03:40:52,612 --> 03:40:54,080
TO REACH OUT STRATEGICALLY AND

5609
03:40:54,080 --> 03:40:55,782
I'D BE HAPPY TO HELP THINK

5610
03:40:55,782 --> 03:40:57,751
THROUGH THAT IF I CAN BE OF

5611
03:40:57,751 --> 03:40:58,318
HELP.

5612
03:40:58,318 --> 03:41:00,053
>> YEAH, THAT WOULD BE
GREAT,

5613
03:41:00,053 --> 03:41:00,220
AMY.

5614
03:41:00,220 --> 03:41:03,656
I THINK TOO THERE ARE THE

5615
03:41:03,656 --> 03:41:04,424
TYPICAL ADVOCACY ORGANIZATIONS

5616
03:41:04,424 --> 03:41:05,959
AND PATIENT GROUPS WE WORK WITH

5617
03:41:05,959 --> 03:41:08,395
REGULARLY BUT THERE ARE SO MANY

5618
03:41:08,395 --> 03:41:09,362
THAT WE HAVEN'T CONNECTED WITH

5619
03:41:09,362 --> 03:41:11,431
AND THIS IS JUST A GREAT

5620
03:41:11,431 --> 03:41:13,199
OPPORTUNITY TO BUILD THOSE

5621
03:41:13,199 --> 03:41:14,267
RELATIONSHIPS SO, YEAH, WOULD

5622
03:41:14,267 --> 03:41:15,268
LOVE TO THINK THROUGH THAT WITH

5623
03:41:15,268 --> 03:41:15,502
YOU.

5624
03:41:15,502 --> 03:41:18,671
THANK YOU.

5625
03:41:18,671 --> 03:41:20,507
>> JUST A QUICK QUESTION.

5626
03:41:20,507 --> 03:41:22,709
I THINK THESE ARE GREAT POINTS

5627
03:41:22,709 --> 03:41:24,444
THAT VALIDATE WHY IT'S SO

5628
03:41:24,444 --> 03:41:28,615
IMPORTANT TO HAVE A DOCUMENT, 

5629
03:41:28,615 --> 03:41:29,916
LEGACY OF INSTITUTION OR ANY

5630
03:41:29,916 --> 03:41:30,316
ORGANIZATION.

5631
03:41:30,316 --> 03:41:31,751
YOU PHRASED IT BEAUTIFUL.

5632
03:41:31,751 --> 03:41:34,721
ONE THING EFFECTIVE LAST TIME

5633
03:41:34,721 --> 03:41:36,189
AROUND WAS BUD ROWAN'S BOOK,

5634
03:41:36,189 --> 03:41:38,391
WHICH LOOKED BACK.

5635
03:41:38,391 --> 03:41:40,293
YOU'VE SHOWN IT.

5636
03:41:40,293 --> 03:41:42,495
IT WAS SHOWN IN THE ANNOUNCEMENT

5637
03:41:42,495 --> 03:41:45,598
OF YOUR TALK TODAY, EXCELLENT

5638
03:41:45,598 --> 03:41:49,736
SUMMARY OF FIRST 50 YEARS OF

5639
03:41:49,736 --> 03:41:50,170
NINDS.

5640
03:41:50,170 --> 03:41:53,006
SOME OF US DO NOT HAVE TWITTER

5641
03:41:53,006 --> 03:41:54,374
OTHER X MACHINES.

5642
03:41:54,374 --> 03:41:55,275
WE'RE DIGITALLY UNFRIENDLY.

5643
03:41:55,275 --> 03:41:56,843
BUT A BOOK IS SOMETHING THAT'S

5644
03:41:56,843 --> 03:42:00,180
DURABLE, A LOT OF PHOTOGRAPHS,

5645
03:42:00,180 --> 03:42:05,785
TEXT, AND IN SOME CASE HAS A

5646
03:42:05,785 --> 03:42:10,190
KIND OF PERMANENCE AS A RECORD

5647
03:42:10,190 --> 03:42:11,157
THAT'S COMMENDABLE.

5648
03:42:11,157 --> 03:42:11,925
>> THANK YOU, BOB.

5649
03:42:11,925 --> 03:42:13,893
THINKING THROUGH ALL DIFFERENT

5650
03:42:13,893 --> 03:42:15,962
TYPES OF MATERIALS, RIGHT,

5651
03:42:15,962 --> 03:42:16,863
DIGITAL PIECE, CERTAINLY THAT'S

5652
03:42:16,863 --> 03:42:18,932
THE DIRECTION WE'RE HEADING IN

5653
03:42:18,932 --> 03:42:21,000
BUT ALSO WHAT OTHER DURABLE

5654
03:42:21,000 --> 03:42:26,372
RESOURCES AND PRINT MATERIALS 

5655
03:42:26,372 --> 03:42:30,310
CAN WE ALSO DEVELOP.

5656
03:42:30,310 --> 03:42:36,316
>> ALISSA, YOU NEED TO GET
YOUR

5657
03:42:36,316 --> 03:42:37,283
PLANE TICKETS READY.

5658
03:42:37,283 --> 03:42:39,619
FOLKS CAN REACH OUT TO YOU

5659
03:42:39,619 --> 03:42:40,420
DIRECTLY.

5660
03:42:40,420 --> 03:42:40,687
>> YES.

5661
03:42:40,687 --> 03:42:41,654
>> WITH THEIR IDEAS.

5662
03:42:41,654 --> 03:42:44,090
>> I JUST WANTED TO ECHO
WE'LL

5663
03:42:44,090 --> 03:42:45,825
BE REACHING OUT TO COUNCIL

5664
03:42:45,825 --> 03:42:46,926
GENERALLY TO GIVE EVERYBODY THE

5665
03:42:46,926 --> 03:42:47,894
OPPORTUNITY TO CIRCLE BACK WITH

5666
03:42:47,894 --> 03:42:50,096
US AND GIVE US YOUR IDEAS AND

5667
03:42:50,096 --> 03:42:51,397
ENGAGE WITH YOU IN DIFFERENT

5668
03:42:51,397 --> 03:42:54,033
WAYS AS WE MOVE FORWARD IN THIS

5669
03:42:54,033 --> 03:42:54,467
PLANNING PROCESS.

5670
03:42:54,467 --> 03:42:57,971
THANK YOU FOR YOUR ENTHUSIASM.

5671
03:42:57,971 --> 03:42:58,505
>> EXCELLENT.

5672
03:42:58,505 --> 03:42:59,606
THANKS, ALL.

5673
03:42:59,606 --> 03:43:00,240
>> THANKS, AMY.

5674
03:43:00,240 --> 03:43:01,808
THANKS, EVERYONE.

5675
03:43:01,808 --> 03:43:04,644
>> WE'RE MOVING TO OUR
FINAL

5676
03:43:04,644 --> 03:43:05,278
ITEM.

5677
03:43:05,278 --> 03:43:08,047
WE HAVE THE SCIENTIFIC DIRECTOR

5678
03:43:08,047 --> 03:43:09,816
OF INTRAMURAL PROGRAM, JEFF

5679
03:43:09,816 --> 03:43:10,450
DIAMOND.

5680
03:43:10,450 --> 03:43:11,651
HE'S GOING TO TELL US, GIVE US

5681
03:43:11,651 --> 03:43:13,319
AN UPDATE ON THE INTRAMURAL

5682
03:43:13,319 --> 03:43:13,753
PROGRAM.

5683
03:43:13,753 --> 03:43:16,156
JEFF, ARE YOU WITH US?

5684
03:43:16,156 --> 03:43:19,792
THERE HE IS. 

5685
03:43:19,792 --> 03:43:22,428
>> MORE OR LESS.

5686
03:43:22,428 --> 03:43:22,929
>> HELLO, EVERYBODY.

5687
03:43:22,929 --> 03:43:25,932
I'D LIKE TO THANK DAVID AND

5688
03:43:25,932 --> 03:43:28,568
LEADERSHIP FOR THIS AWESOME TIME

5689
03:43:28,568 --> 03:43:29,135
SLOT.

5690
03:43:29,135 --> 03:43:29,402
[LAUGHTER]

5691
03:43:29,402 --> 03:43:31,171
WHEN DAVID WAS TELLING ME I'D BE

5692
03:43:31,171 --> 03:43:33,373
CUTTING INTO YOUR VALENTINE'S

5693
03:43:33,373 --> 03:43:36,876
DAY DINNER PLANS, HE ALSO SAID

5694
03:43:36,876 --> 03:43:38,378
THAT YOU'RE MORE INCLINED,

5695
03:43:38,378 --> 03:43:41,814
COUNCIL IS MORE INCLUDE TO A

5696
03:43:41,814 --> 03:43:43,249
DISCUSSION RATHER THAN

5697
03:43:43,249 --> 03:43:43,583
PRESENTATION.

5698
03:43:43,583 --> 03:43:45,451
SO IN THAT SPIRIT I'M GOING TO

5699
03:43:45,451 --> 03:43:49,622
TRY TO KEEP MY COMMENTS

5700
03:43:49,622 --> 03:43:52,959
RELATIVELY BRIEF BUT I DO WANT

5701
03:43:52,959 --> 03:43:56,129
TO TAKE SOME TIME TO TALK ABOUT

5702
03:43:56,129 --> 03:44:00,133
SOME NEW ADDITIONS TO THE

5703
03:44:00,133 --> 03:44:02,202
INTRAMURAL PROGRAM AND SOME

5704
03:44:02,202 --> 03:44:05,905
EXCITING ROLES FOR SOME PEOPLE

5705
03:44:05,905 --> 03:44:09,108
AND TRANSITIONS, A SHORT COMMENT

5706
03:44:09,108 --> 03:44:11,477
ON THE EFFORTS OF THE FELLOWS TO

5707
03:44:11,477 --> 03:44:13,446
UNIONIZE AT NIH BUT THEN I CAN'T

5708
03:44:13,446 --> 03:44:15,648
HELP BUT JUST TAKE A LITTLE BIT

5709
03:44:15,648 --> 03:44:18,384
OF TIME AT THE END TO TALK VERY

5710
03:44:18,384 --> 03:44:20,019
BRIEFLY ABOUT SOME COOL SCIENCE

5711
03:44:20,019 --> 03:44:24,824
THAT'S GOING ON IN THE

5712
03:44:24,824 --> 03:44:26,125
INTRAMURAL PROGRAM.

5713
03:44:26,125 --> 03:44:29,429
I UNDERSTAND I'M LIMITED TO 75

5714
03:44:29,429 --> 03:44:30,630
SECONDS OF ATTENTION SPAN AND SO

5715
03:44:30,630 --> 03:44:35,134
EACH OF THOSE I PROMISE WILL NOT

5716
03:44:35,134 --> 03:44:36,002
EXCEED THAT.

5717
03:44:36,002 --> 03:44:39,172
WE HAVE -- IT'S BEEN A COUPLE

5718
03:44:39,172 --> 03:44:45,845
YEARS I THINK SINCE YOU'VE HEARD

5719
03:44:45,845 --> 03:44:47,947
FROM THE INTRAMURAL PROGRAM WITH

5720
03:44:47,947 --> 03:44:51,084
THE CHANGES THAT OCCURRED IN

5721
03:44:51,084 --> 03:44:52,218
INTRAMURAL LEADERSHIP.

5722
03:44:52,218 --> 03:44:55,722
A LOT HAS HAPPENED IN THAT TIME.

5723
03:44:55,722 --> 03:45:00,093
WE'VE HAD A LOT OF NEW FACES

5724
03:45:00,093 --> 03:45:00,293
COME.

5725
03:45:00,293 --> 03:45:04,931
WE HAVE THREE ASSISTANT CLINICAL

5726
03:45:04,931 --> 03:45:06,332
INVESTIGATORS THAT ARE -- THAT

5727
03:45:06,332 --> 03:45:07,567
INTEGRATED INTO THE COMMUNITY

5728
03:45:07,567 --> 03:45:08,968
AND ARE WORKING HARD.

5729
03:45:08,968 --> 03:45:12,238
YOU CAN SEE THIS ON THE LEFT.

5730
03:45:12,238 --> 03:45:16,609
WE HAVE A NUMBER OF NEW TENURE

5731
03:45:16,609 --> 03:45:18,378
TRACK INVESTIGATORS THAT YOU CAN

5732
03:45:18,378 --> 03:45:23,549
SEE IN THE MIDDLE WORKING IN A

5733
03:45:23,549 --> 03:45:29,422
RANGE OF DIFFERENT AREAS.

5734
03:45:29,422 --> 03:45:31,524
I ANTICIPATE THIS LIST TO GET

5735
03:45:31,524 --> 03:45:34,260
SMALLER IN THE NEXT MONTH OR TWO

5736
03:45:34,260 --> 03:45:36,329
AS SONIA AND ARIEL ARE GOING TO

5737
03:45:36,329 --> 03:45:39,332
BE PRESENTED BY ME TO THE

5738
03:45:39,332 --> 03:45:40,300
CENTRAL TENURE COMMITTEE AND I

5739
03:45:40,300 --> 03:45:42,802
IMAGINE THEY WILL BE MOVING OVER

5740
03:45:42,802 --> 03:45:45,204
TO THE RIGHT SIDE HERE WHICH

5741
03:45:45,204 --> 03:45:49,142
SHOWS THE FOLKS WHO HAVE

5742
03:45:49,142 --> 03:45:49,976
SUCCESSFULLY NEGOTIATED THE

5743
03:45:49,976 --> 03:45:52,445
CENTRAL TENURE COMMITTEE AND ARE

5744
03:45:52,445 --> 03:45:53,646
NOW SENIOR INVESTIGATORS WITH

5745
03:45:53,646 --> 03:45:57,150
TENURE AND THEY ARE OVER HERE ON

5746
03:45:57,150 --> 03:45:58,685
THE RIGHT.

5747
03:45:58,685 --> 03:46:05,425
SO, WE HAVE A REALLY HEALTHY

5748
03:46:05,425 --> 03:46:08,594
COHORT OF YOUNG AND SORT OF

5749
03:46:08,594 --> 03:46:12,465
EARLY MID-CAREER PEOPLE IN THE

5750
03:46:12,465 --> 03:46:13,399
INSTITUTE.

5751
03:46:13,399 --> 03:46:18,404
THAT'S BEEN REALLY EXCITING TO

5752
03:46:18,404 --> 03:46:19,072
SEE.

5753
03:46:19,072 --> 03:46:23,343
SOME OF OUR SENIOR INVESTIGATORS

5754
03:46:23,343 --> 03:46:30,683
HAVE ALSO TAKEN ON NEW ROLES,

5755
03:46:30,683 --> 03:46:33,853
RESPONSIBILITIES, AND HONORS.

5756
03:46:33,853 --> 03:46:37,590
KAREEM IS NEW BRANCH CHIEF OF

5757
03:46:37,590 --> 03:46:39,759
SURGICAL NEUROLOGY BRANCH.

5758
03:46:39,759 --> 03:46:41,227
I'LL TALK ABOUT KAREEM'S

5759
03:46:41,227 --> 03:46:42,829
RESEARCH, HE'S ALSO DOING A

5760
03:46:42,829 --> 03:46:46,432
GREAT JOB SO FAR AS THE BRANCH

5761
03:46:46,432 --> 03:46:46,766
CHIEF.

5762
03:46:46,766 --> 03:46:49,702
THERE ARE TWO THINGS TO NOTE

5763
03:46:49,702 --> 03:46:53,439
ABOUT NEW ROLES IN THE LARGER

5764
03:46:53,439 --> 03:46:54,240
NEUROSCIENCE COMMUNITY, JUDIE

5765
03:46:54,240 --> 03:46:57,043
WALTERS IS THE CHAIR OF THE

5766
03:46:57,043 --> 03:46:59,879
NEUROSCIENCE STEERING COMMITTEE

5767
03:46:59,879 --> 03:47:01,214
OF AAAS, KATHERINE ROCHE WAS

5768
03:47:01,214 --> 03:47:03,816
RECENTLY ELECTED TO BE THE

5769
03:47:03,816 --> 03:47:11,491
SECRETARY-ELECT FOR SOCIETY FOR 

5770
03:47:11,491 --> 03:47:12,191
NEUROSCIENCE.

5771
03:47:12,191 --> 03:47:13,559
RICHARD YOULE WHO MADE OUR NEWS

5772
03:47:13,559 --> 03:47:16,295
A COUPLE YEARS AGO BY WINNING A

5773
03:47:16,295 --> 03:47:19,365
BREAKTHROUGH PRIZE, BY THE WAY

5774
03:47:19,365 --> 03:47:22,335
SORT OF GOT THE LID OFF THE

5775
03:47:22,335 --> 03:47:24,203
BREAKTHROUGH PRIZE TAP, WE NOW

5776
03:47:24,203 --> 03:47:25,204
HAVE TWO OTHER BREAKTHROUGH

5777
03:47:25,204 --> 03:47:27,039
PRIZE WINNERS IN THE SAME

5778
03:47:27,039 --> 03:47:32,512
BUILDING THAT RICHARD WORKS IN,

5779
03:47:32,512 --> 03:47:36,349
RECENTLY BEEN APPOINTED AS NIH

5780
03:47:36,349 --> 03:47:37,450
DISTINGUISHED INVESTIGATOR,

5781
03:47:37,450 --> 03:47:40,820
WHICH IS AN HONOR THAT IS

5782
03:47:40,820 --> 03:47:43,656
BESTOWED ONLY ON 2 TO 3% OF

5783
03:47:43,656 --> 03:47:45,224
SENIOR INVESTIGATORS IN THE

5784
03:47:45,224 --> 03:47:47,627
INTRAMURAL PROGRAM ACROSS NIH.

5785
03:47:47,627 --> 03:47:53,566
SO IT'S A TREMENDOUS AND WELL 

5786
03:47:53,566 --> 03:47:57,603
DESERVED HONOR FOR RICHARD.

5787
03:47:57,603 --> 03:48:00,239
HIRES ARE ACCOMPANIED BY

5788
03:48:00,239 --> 03:48:07,113
RETIREMENTS, IT'S NICE TO SEE 

5789
03:48:07,113 --> 03:48:08,681
THAT RETIREES HAVE CONSISTENTLY

5790
03:48:08,681 --> 03:48:09,248
REQUESTED EMERITUS STATUS,

5791
03:48:09,248 --> 03:48:13,352
THAT'S ONE OF THE PLEASURES THE

5792
03:48:13,352 --> 03:48:16,289
SD HAS, TO PRESENT THEIR

5793
03:48:16,289 --> 03:48:18,858
NOMINATION FOR EMERITUS TO THE

5794
03:48:18,858 --> 03:48:21,794
SCIENTIFIC DIRECTORS AND

5795
03:48:21,794 --> 03:48:24,831
CLINICAL DIRECTORS WHO HAVE

5796
03:48:24,831 --> 03:48:27,500
UNANIMOUSLY APPROVED ALL OF THE

5797
03:48:27,500 --> 03:48:28,701
APPOINTEES NINDS PUT FORWARD,

5798
03:48:28,701 --> 03:48:31,537
AND YOU CAN SEE ALL OF THEM

5799
03:48:31,537 --> 03:48:33,940
HERE, KURT FISCHBECK HAS NOT

5800
03:48:33,940 --> 03:48:38,878
BEEN PUT FORWARD  YET BUT NOT A

5801
03:48:38,878 --> 03:48:43,583
DIFFICULT SALES JOB WITH THE 

5802
03:48:43,583 --> 03:48:43,749
SDs.

5803
03:48:43,749 --> 03:48:49,622
IT'S NICE TO SEE SEVERAL EMERITI

5804
03:48:49,622 --> 03:48:50,990
ARE EXPRESSING INTEREST IN

5805
03:48:50,990 --> 03:48:55,394
BANDING TOGETHER AND HAVING A 

5806
03:48:55,394 --> 03:48:58,564
BIT OF AN EMERITI COMMUNITY ON

5807
03:48:58,564 --> 03:49:04,804
CAMPUS, AND THAT'S NICE TO SEE.

5808
03:49:04,804 --> 03:49:07,974
THERE'S BEEN A MAJOR DEVELOPMENT

5809
03:49:07,974 --> 03:49:13,012
IN OF AMONG FELLOWS AT NIH.

5810
03:49:13,012 --> 03:49:18,017
IN DECEMBER A MAJORITY OF THE

5811
03:49:18,017 --> 03:49:23,956
FELLOWS WHO VOTED ON THE UNION

5812
03:49:23,956 --> 03:49:27,126
VOTED TO BE REPRESENTED BY

5813
03:49:27,126 --> 03:49:27,393
U.A.W.

5814
03:49:27,393 --> 03:49:31,998
AND THE FEDERAL LABOR RELATIONS

5815
03:49:31,998 --> 03:49:37,770
AUTHORITY CERTIFIED U.A.W. AS

5816
03:49:37,770 --> 03:49:39,805
BARGAINING UNIT ON DECEMBER 15,

5817
03:49:39,805 --> 03:49:42,408
AND WILL REPRESENT 5,000 FELLOWS

5818
03:49:42,408 --> 03:49:43,576
AT NIH.

5819
03:49:43,576 --> 03:49:46,412
AND SO NIH WILL PARTNER WITH

5820
03:49:46,412 --> 03:49:49,815
U.A.W. TO NEGOTIATE WHAT WILL BE

5821
03:49:49,815 --> 03:49:51,584
AN HISTORIC AGREEMENT BECAUSE I

5822
03:49:51,584 --> 03:49:53,452
DON'T BELIEVE THERE'S BEEN THIS

5823
03:49:53,452 --> 03:49:58,424
KIND OF AGREEMENT WITH A GROUP

5824
03:49:58,424 --> 03:50:03,195
IN THE FEDERAL GOVERNMENT.

5825
03:50:03,195 --> 03:50:07,500
SO, THAT'S HAPPENING AND IT WILL

5826
03:50:07,500 --> 03:50:12,538
BE INTERESTING TO SEE HOW THAT

5827
03:50:12,538 --> 03:50:13,639
PLAYS OUT.

5828
03:50:13,639 --> 03:50:16,576
SO, IF ANYBODY HAS ANY QUESTIONS

5829
03:50:16,576 --> 03:50:22,415
ABOUT THIS, I WOULD BE HAPPY TO

5830
03:50:22,415 --> 03:50:25,651
FIELD QUESTIONS ABOUT THE UNION

5831
03:50:25,651 --> 03:50:27,086
WITH ADROITLY DELIVERED

5832
03:50:27,086 --> 03:50:29,055
NON-ANSWERS BECAUSE WE REALLY

5833
03:50:29,055 --> 03:50:31,891
AREN'T ALLOWED TO SAY MUCH OF

5834
03:50:31,891 --> 03:50:32,658
ANYTHING ABOUT ANY DETAILS ABOUT

5835
03:50:32,658 --> 03:50:33,426
THE UNION.

5836
03:50:33,426 --> 03:50:34,760
I DON'T REALLY KNOW ANYTHING, TO

5837
03:50:34,760 --> 03:50:37,163
BE HONEST.

5838
03:50:37,163 --> 03:50:39,999
THERE'S BEEN VERY LITTLE

5839
03:50:39,999 --> 03:50:40,633
SUBSTANTIVE INFORMATION COMING

5840
03:50:40,633 --> 03:50:46,906
DOWN THE PIKE. 

5841
03:50:46,906 --> 03:50:47,106
OKAY.

5842
03:50:47,106 --> 03:50:53,145
WHAT I'D LIKE TO DO IS JUST GIVE

5843
03:50:53,145 --> 03:50:54,981
A FEW VIGNETTES ABOUT SOME WORK

5844
03:50:54,981 --> 03:50:58,184
THAT IS BEING DONE AT DIFFERENT

5845
03:50:58,184 --> 03:51:01,354
PARTS OF THE INTRAMURAL PROGRAM

5846
03:51:01,354 --> 03:51:03,089
JUST BECAUSE QUITE FRANKLY

5847
03:51:03,089 --> 03:51:09,428
THAT'S BEEN ONE OF THE REAL

5848
03:51:09,428 --> 03:51:11,197
PLEASURES, TALKING ABOUT THEIR

5849
03:51:11,197 --> 03:51:13,699
SCIENCE AND IT'S DAUNTING TRYING

5850
03:51:13,699 --> 03:51:16,869
TO PRESENT THIS WORK IN SUCH AN

5851
03:51:16,869 --> 03:51:18,404
ABBREVIATED FASHION.

5852
03:51:18,404 --> 03:51:19,505
I'M RELIEVED NONE OF THE PEOPLE

5853
03:51:19,505 --> 03:51:21,574
WHO IS WORK I'M GOING TO TALK

5854
03:51:21,574 --> 03:51:22,908
ABOUT ARE ON THIS CALL.

5855
03:51:22,908 --> 03:51:24,744
IT'S A LITTLE BIT OF COMFORT.

5856
03:51:24,744 --> 03:51:29,115
BUT I WOULD LIKE TO JUST SHOW

5857
03:51:29,115 --> 03:51:31,851
THAT THERE'S WORK AT ALL LEVELS

5858
03:51:31,851 --> 03:51:35,988
OF STUDY OF THE NERVOUS SYSTEM,

5859
03:51:35,988 --> 03:51:38,391
AND I REALIZE AFTER I DID THIS

5860
03:51:38,391 --> 03:51:42,261
THAT EACH ONE OF THESE HAS, YOU

5861
03:51:42,261 --> 03:51:45,531
KNOW, AN AUTHENTIC CONNECTION TO

5862
03:51:45,531 --> 03:51:46,399
NEUROLOGICAL DISEASE.

5863
03:51:46,399 --> 03:51:48,334
SO, I THINK THE FIRST ONE THAT

5864
03:51:48,334 --> 03:51:53,305
I'D LIKE TO TALK ABOUT COMES

5865
03:51:53,305 --> 03:51:55,274
FROM KENTON SCHWARTZ'S LAB,

5866
03:51:55,274 --> 03:51:57,009
WORKING HERE FOR OVER 25 YEARS

5867
03:51:57,009 --> 03:51:58,678
LOOKING AT THE BIOPHYSICAL

5868
03:51:58,678 --> 03:52:01,847
MECHANISMS OF ION CHANNEL

5869
03:52:01,847 --> 03:52:03,683
FUNCTION, STRUCTURE/FUNCTION

5870
03:52:03,683 --> 03:52:05,718
RELATIONSHIPS.

5871
03:52:05,718 --> 03:52:08,387
RECENTLY HE'S BECOME INTERESTED

5872
03:52:08,387 --> 03:52:14,093
IN THE MECHANISMS OF ION CHANNEL

5873
03:52:14,093 --> 03:52:17,697
INACTIVATION, AND THIS IS THE

5874
03:52:17,697 --> 03:52:24,704
CLASSIC IMAGE OF AT LEAST N TYPE

5875
03:52:24,704 --> 03:52:28,441
INACTIVATION, THOUGHT TO BE

5876
03:52:28,441 --> 03:52:30,443
MEDIATED BY BALL AND CHAIN

5877
03:52:30,443 --> 03:52:31,610
MECHANISM, A BALL PLUGS THE

5878
03:52:31,610 --> 03:52:33,913
CHANNEL, THE CHANNEL IS OPEN BUT

5879
03:52:33,913 --> 03:52:39,618
BLOCKED AND NO LONGER 

5880
03:52:39,618 --> 03:52:40,786
CONDUCTING.

5881
03:52:40,786 --> 03:52:42,154
NOW, INTERESTINGLY ATTENTION WAS

5882
03:52:42,154 --> 03:52:45,324
PIQUED RECENTLY BY THE REPORT OF

5883
03:52:45,324 --> 03:52:55,835
MUTATIONS IN THE INNER PORE OF

5884
03:52:55,835 --> 03:52:57,036
VOLTAGE GATED POTASSIUM CHANNEL,

5885
03:52:57,036 --> 03:53:00,773
IT'S A PATIENT MUTATION THAT

5886
03:53:00,773 --> 03:53:05,144
CAUSES EPILEPTIC ENCEPHALOPATHY.

5887
03:53:05,144 --> 03:53:10,049
SO, THIS LAB LOOKED INTO THIS,

5888
03:53:10,049 --> 03:53:10,816
AND USED CRYO-ELECTRON

5889
03:53:10,816 --> 03:53:16,288
MICROSCOPY TO DETERMINE THE

5890
03:53:16,288 --> 03:53:21,660
THREE DIMENSIONAL STRUCTURE OF 

5891
03:53:21,660 --> 03:53:23,729
THIS POTASSIUM CHANNEL, KV2.1,

5892
03:53:23,729 --> 03:53:29,769
THIS IS THE WILD TYPE AND

5893
03:53:29,769 --> 03:53:30,936
MUTATED FORM.

5894
03:53:30,936 --> 03:53:32,805
THEY WERE ABLE TO SOLVE THE

5895
03:53:32,805 --> 03:53:37,276
STRUCTURE OF WHAT THEY CALL A

5896
03:53:37,276 --> 03:53:38,177
HYDROPHOBIC NEXUS NEAR THE

5897
03:53:38,177 --> 03:53:43,516
INTERNAL PART OF THE PORE THAT

5898
03:53:43,516 --> 03:53:46,585
CONTROLS KV2.1 INACTIVATION.

5899
03:53:46,585 --> 03:53:55,060
YOU CAN SEE THIS KEY MUTATION IN

5900
03:53:55,060 --> 03:53:56,128
L403 IS RIGHT HERE.

5901
03:53:56,128 --> 03:53:57,797
WHAT THEY FOUND WHEN THEY SOLVED

5902
03:53:57,797 --> 03:54:01,200
THE STRUCTURE OF THE MUTATED

5903
03:54:01,200 --> 03:54:04,370
CHANNEL IS ACTUALLY A

5904
03:54:04,370 --> 03:54:06,338
SIGNIFICANT DISTORTION OF THE

5905
03:54:06,338 --> 03:54:07,973
INTERNAL PART OF THE POTASSIUM

5906
03:54:07,973 --> 03:54:12,912
CHANNEL PORE, SHOWING THIS IS

5907
03:54:12,912 --> 03:54:14,547
ACTUALLY THE MECHANISM OF THE

5908
03:54:14,547 --> 03:54:16,182
INACTIVATION AND THEY THINK THAT

5909
03:54:16,182 --> 03:54:19,919
IT'S COMMON TO A NUMBER OF

5910
03:54:19,919 --> 03:54:20,686
DIFFERENT VOLTAGE GATED

5911
03:54:20,686 --> 03:54:23,823
CHANNELS, THIS REGION IS

5912
03:54:23,823 --> 03:54:25,157
CONSERVED, SODIUM POTASSIUM

5913
03:54:25,157 --> 03:54:27,026
CALCIUM CHANNELS, IS VERY CLOSE

5914
03:54:27,026 --> 03:54:31,931
TO THE SITE WHERE THE BALL COMES

5915
03:54:31,931 --> 03:54:34,333
IN, IN BALL AND CHAIN

5916
03:54:34,333 --> 03:54:35,000
INACTIVATION.

5917
03:54:35,000 --> 03:54:38,170
RATHER THAN PLUGGING THE 

5918
03:54:38,170 --> 03:54:39,905
CHANNEL, THAT BALL AND CHAIN

5919
03:54:39,905 --> 03:54:41,340
INACTIVATION MIGHT BE WORKING TO

5920
03:54:41,340 --> 03:54:42,975
DISTORT THE PORE.

5921
03:54:42,975 --> 03:54:48,247
SO I THOUGHT THIS WAS A COOL

5922
03:54:48,247 --> 03:54:49,348
THING AND SPENT MORE THAN 75

5923
03:54:49,348 --> 03:54:52,918
SECONDS SO I'LL SPEED UP. 

5924
03:54:52,918 --> 03:54:54,687
NEXT FROM SONIA SCHULTZ'S LAB,

5925
03:54:54,687 --> 03:54:59,391
COMING UP FOR TENURE NEXT MONTH.

5926
03:54:59,391 --> 03:55:04,864
SHE IS A GENETICIST WHO TAKES

5927
03:55:04,864 --> 03:55:07,600
ADVANTAGES OF THE AMOUNT OF

5928
03:55:07,600 --> 03:55:09,335
INFORMATION GENERATED BY

5929
03:55:09,335 --> 03:55:10,870
DIFFERENT GENOMICS CONSORTIA,

5930
03:55:10,870 --> 03:55:15,040
PROVIDING A LOT OF INFORMATION

5931
03:55:15,040 --> 03:55:16,675
ABOUT -- NOT ONLY HEALTHY

5932
03:55:16,675 --> 03:55:25,317
CONTROLS BUT LEWY BODY DEMENTIA,

5933
03:55:25,317 --> 03:55:27,186
FRONTOTEMPORAL IN ALS, THIS

5934
03:55:27,186 --> 03:55:28,821
PAPERS LOOKS AT DIFFERENT CASES.

5935
03:55:28,821 --> 03:55:33,993
I WANT TO POINT OUT AS AN

5936
03:55:33,993 --> 03:55:36,295
EXAMPLE THE ANALYSIS OF OVER

5937
03:55:36,295 --> 03:55:39,231
2,000 LEWY BODY DEMENTIA CASES

5938
03:55:39,231 --> 03:55:43,736
ALONG WITH ALMOST 4,000 

5939
03:55:43,736 --> 03:55:46,672
CONTROLS, THERE WOULD BE NOVEL

5940
03:55:46,672 --> 03:55:49,742
RISK LOCUS WHICH IS MUTATION IN

5941
03:55:49,742 --> 03:55:52,378
GENE ENCODING ION CHANNEL,

5942
03:55:52,378 --> 03:55:57,983
TWO-PORE CALCIUM CHANNEL, THAT

5943
03:55:57,983 --> 03:55:59,418
ACTUALLY OPERATES ON

5944
03:55:59,418 --> 03:56:01,020
EXTRACELLULAR ORGANELLES TO

5945
03:56:01,020 --> 03:56:03,789
REGULATE RELEASE OF CALCIUM AND

5946
03:56:03,789 --> 03:56:08,594
PLAYS A ROLE IN LONG-TERM

5947
03:56:08,594 --> 03:56:10,396
POTENTIATION AND ALSO SPATIAL

5948
03:56:10,396 --> 03:56:13,299
LEARNING AND MEMORY.

5949
03:56:13,299 --> 03:56:18,771
IT'S NEAT THIS ANALYSIS SO

5950
03:56:18,771 --> 03:56:21,273
SPECIFICALLY POINTED TO A

5951
03:56:21,273 --> 03:56:24,476
PROTEIN THAT LOGICALLY PLAYS A

5952
03:56:24,476 --> 03:56:30,683
ROLE IN CELLULAR MODEL OF

5953
03:56:30,683 --> 03:56:37,389
LEARNING AND MEMORY. 

5954
03:56:37,389 --> 03:56:38,791
DORIAN McGAFFERN UNDERWENT A

5955
03:56:38,791 --> 03:56:49,301
BOARD OF SCIENTIFIC COUNSELOR

5956
03:56:50,169 --> 03:56:52,171
REVIEW, BRAIN INSULTS,

5957
03:56:52,171 --> 03:56:53,138
CEREBROVASCULAR INJURY, ALSO

5958
03:56:53,138 --> 03:56:55,774
RESPONSE TO STROKE.

5959
03:56:55,774 --> 03:56:58,510
AND IN THIS STUDY HE LOOKED AT

5960
03:56:58,510 --> 03:57:02,815
TWO KINDS OF INSULTS.

5961
03:57:02,815 --> 03:57:07,720
HERE HE'S IMAGING MICROGLIA WITH

5962
03:57:07,720 --> 03:57:10,222
A MARKER IBA1 THAT LIGHTS UP

5963
03:57:10,222 --> 03:57:12,758
MICROGLIA IN CONTROL, AND IN

5964
03:57:12,758 --> 03:57:15,260
RESPONSE TO INJURY USING

5965
03:57:15,260 --> 03:57:17,129
DIRECTED DELIVERY OF

5966
03:57:17,129 --> 03:57:19,198
MICROBUBBLES, THIS IS THROUGH A

5967
03:57:19,198 --> 03:57:21,200
THIN -- IMAGING THROUGH A THIN

5968
03:57:21,200 --> 03:57:23,902
PART OF THE MOUSE SKULL, AND YOU

5969
03:57:23,902 --> 03:57:26,772
CAN SEE THAT IN RESPONSE TO THE

5970
03:57:26,772 --> 03:57:30,242
INJURY, THERE IS A LARGE NUMBER

5971
03:57:30,242 --> 03:57:33,679
OF NEW MICROGLIA DELIVERED AND

5972
03:57:33,679 --> 03:57:38,283
THESE ARE VEGF POSITIVE AND ARE

5973
03:57:38,283 --> 03:57:39,151
ALSO EXPRESSING INTERLEUKIN 6

5974
03:57:39,151 --> 03:57:39,551
RECEPTOR.

5975
03:57:39,551 --> 03:57:43,222
YOU CAN SEE DOWN HERE IF YOU

5976
03:57:43,222 --> 03:57:47,593
LOOK AT THE TRANSCRIPTOMIC

5977
03:57:47,593 --> 03:57:50,863
PROFILE OF CELLS, IN CONTROL,

5978
03:57:50,863 --> 03:57:53,932
AND FOLLOWING THE INJURY, YOU

5979
03:57:53,932 --> 03:57:55,467
SEE EXPANSION OF THIS POPULATION

5980
03:57:55,467 --> 03:57:57,336
OF MICROGLIA.

5981
03:57:57,336 --> 03:58:00,506
THESE ARE WHAT HE CALLS REPAIR

5982
03:58:00,506 --> 03:58:02,408
ASSOCIATED MICROGLIA.

5983
03:58:02,408 --> 03:58:05,677
YOU SEE THESE FOLLOWING STROKE.

5984
03:58:05,677 --> 03:58:10,015
SO THIS IS TISSUE FROM HUMAN

5985
03:58:10,015 --> 03:58:12,317
STROKE PATIENT, SHOWING THE

5986
03:58:12,317 --> 03:58:14,953
BORDER OF THE INFARCT AND

5987
03:58:14,953 --> 03:58:16,922
PERIINFARCT, JUST OUTSIDE THE

5988
03:58:16,922 --> 03:58:20,025
BORDER OF INFARCT YOU SEE NEW

5989
03:58:20,025 --> 03:58:25,764
VEGF A-POSITIVE MICROGLIA,

5990
03:58:25,764 --> 03:58:27,099
CLEARLY ANALOGOUS PROCESS GOING

5991
03:58:27,099 --> 03:58:27,266
ON.

5992
03:58:27,266 --> 03:58:33,605
THEY WENT ON TO SHOW THAT THESE

5993
03:58:33,605 --> 03:58:35,974
RESPONSES AND REPAIR RESPONSE

5994
03:58:35,974 --> 03:58:40,179
IT'S FROM MICROGLIA REQUIRE

5995
03:58:40,179 --> 03:58:42,481
MONOCYTES AND INTERLEUKIN 6, AND

5996
03:58:42,481 --> 03:58:44,283
SO IN A MODEL, MOUSE MODEL, BACK

5997
03:58:44,283 --> 03:58:46,952
IN MOUSE AGAIN, HERE YOU CAN SEE

5998
03:58:46,952 --> 03:58:52,124
THE CONTROL AND ALL THE WHITE

5999
03:58:52,124 --> 03:58:54,493
DOTS ARE NEURONS, FOLLOWING THE

6000
03:58:54,493 --> 03:58:57,362
INJURY HERE IN THE ABSENCE OF

6001
03:58:57,362 --> 03:58:58,764
MONOCYTES WHEN YOU'VE KNOCKED

6002
03:58:58,764 --> 03:59:01,800
DOWN MONOCYTES YOU DON'T GET

6003
03:59:01,800 --> 03:59:03,335
INTO RECOVERY HERE, YOU DON'T

6004
03:59:03,335 --> 03:59:06,438
SEE A LOT OF NEURONS FILLING

6005
03:59:06,438 --> 03:59:10,142
BACK IN HERE, BUT IN THIS CASE

6006
03:59:10,142 --> 03:59:12,444
WHEN YOU SUPPLY INTERLEUKIN 6,

6007
03:59:12,444 --> 03:59:14,179
SEPARATELY, YOU'RE ABLE TO SORT

6008
03:59:14,179 --> 03:59:19,251
OF I GUESS MIMIC THE PRESENCE OF

6009
03:59:19,251 --> 03:59:21,954
THE MONOCYTES AND CAUSE VASCULAR

6010
03:59:21,954 --> 03:59:23,155
REPAIR AND RECOVERY OF THE

6011
03:59:23,155 --> 03:59:29,061
NEURONS IN THIS REGION.

6012
03:59:29,061 --> 03:59:31,797
SO, DORIAN IS DOING A NUMBER

6013
03:59:31,797 --> 03:59:34,433
OF -- HE'S GOT A NUMBER OF

6014
03:59:34,433 --> 03:59:36,101
REALLY COOL PROJECTS THAT HE DID

6015
03:59:36,101 --> 03:59:40,005
A BEAUTIFUL JOB OF PRESENTING IN

6016
03:59:40,005 --> 03:59:46,145
HIS PREVIOUS REVIEW.

6017
03:59:46,145 --> 03:59:49,982
ARIEL LEVINE IS ANOTHER YOUNG

6018
03:59:49,982 --> 03:59:54,353
INVESTIGATOR  STUDYING CELLULAR

6019
03:59:54,353 --> 03:59:55,988
DIVERSITY IN THE SPINAL CORD,

6020
03:59:55,988 --> 03:59:58,624
HAD DONE THIS IN THE MOUSE

6021
03:59:58,624 --> 04:00:01,793
SPINAL CORD, RECENTLY TAKEN ON

6022
04:00:01,793 --> 04:00:06,698
HUMAN SPINAL CORD AND DONE

6023
04:00:06,698 --> 04:00:09,001
TRANSCRIPTOMICS OF TISSUE TAKEN

6024
04:00:09,001 --> 04:00:11,837
FROM 14 HUMAN DONORS, AND WAS

6025
04:00:11,837 --> 04:00:15,874
ABLE TO DISTINGUISH A NUMBER OF

6026
04:00:15,874 --> 04:00:19,611
SPINAL CORD TYPES AND ANALYZE

6027
04:00:19,611 --> 04:00:24,850
THE RANGE OF NEURON TIMES  --

6028
04:00:24,850 --> 04:00:30,889
TYPES T YPES IN THE FINAL CORD,

6029
04:00:30,889 --> 04:00:34,726
WAS ABLE TO START TO MAKE A

6030
04:00:34,726 --> 04:00:36,662
SPATIOTEMPORAL MAP OF THE

6031
04:00:36,662 --> 04:00:46,205
DIFFERENT CELL TYPES.

6032
04:00:46,205 --> 04:00:48,707
DORSAL TYPES, PARTS OF THE

6033
04:00:48,707 --> 04:00:52,844
DORSAL CORD ARE DISTINCT FROM

6034
04:00:52,844 --> 04:00:54,379
TRANSCRIPTOMIC STANDPOINT,

6035
04:00:54,379 --> 04:00:55,814
WHEREAS THINGS ARE MORE BLURRED

6036
04:00:55,814 --> 04:00:57,583
DOWN IN THE VENTRAL PART.

6037
04:00:57,583 --> 04:01:06,458
THIS IS SOMETHING SHE SAW IN THE

6038
04:01:06,458 --> 04:01:06,825
MOUSE.

6039
04:01:06,825 --> 04:01:09,261
AND SO IT PAVES THE WAY, SEEMS

6040
04:01:09,261 --> 04:01:11,697
LIKE THE MOUSE WORK THAT SHE'S

6041
04:01:11,697 --> 04:01:16,301
DOING IS GOING TO RELIABLY

6042
04:01:16,301 --> 04:01:20,005
INFORM, YOU KNOW, THINKING ABOUT

6043
04:01:20,005 --> 04:01:21,440
DIVERSITY IN HUMAN SPINAL CORD

6044
04:01:21,440 --> 04:01:23,809
AS WELL.

6045
04:01:23,809 --> 04:01:26,912
IT'S INTERESTING SHE LOOKS AT

6046
04:01:26,912 --> 04:01:30,082
TRANSCRIPTOMIC PROFILE OF MOTOR

6047
04:01:30,082 --> 04:01:31,883
NEURONS, SEES THEY ARE ENRICHED

6048
04:01:31,883 --> 04:01:36,088
QUITE WELL WITH  A NUMBER OF

6049
04:01:36,088 --> 04:01:39,458
GENES RELATED TO ALS.

6050
04:01:39,458 --> 04:01:43,962
AND SO I THINK THERE'S CLEARLY A

6051
04:01:43,962 --> 04:01:46,999
COOL DISEASE ANGLE ON THIS BUT

6052
04:01:46,999 --> 04:01:49,101
THIS PART IN THE MIDDLE IS

6053
04:01:49,101 --> 04:01:53,171
ENABLING ARIEL I THINK TO START

6054
04:01:53,171 --> 04:01:54,906
TO DISTINGUISH THE CIRCUITRY IN

6055
04:01:54,906 --> 04:01:59,044
THE SPINAL CORD GIVING RISE TO

6056
04:01:59,044 --> 04:02:00,245
DIFFERENT KINDS OF MOVEMENT AND

6057
04:02:00,245 --> 04:02:03,315
SHE'S REALLY -- I REALLY ADMIRE

6058
04:02:03,315 --> 04:02:04,583
THIS.

6059
04:02:04,583 --> 04:02:06,084
SHE'S ATTACKING THAT, TAKING ON

6060
04:02:06,084 --> 04:02:07,619
NEW KINDS OF TECHNOLOGY IN HER

6061
04:02:07,619 --> 04:02:09,554
LAB, SHE WILL START DOING

6062
04:02:09,554 --> 04:02:13,392
PHYSIOLOGY, THIS WILL HELP HER

6063
04:02:13,392 --> 04:02:14,826
IDENTIFY SPECIFIC CELL TYPES, TO

6064
04:02:14,826 --> 04:02:19,097
MANIPULATE AND SEE THEIR ROLE IN

6065
04:02:19,097 --> 04:02:20,399
DIFFERENT KINDS OF MOTOR

6066
04:02:20,399 --> 04:02:28,507
PROGRAMS THAT THE MOUSE

6067
04:02:28,507 --> 04:02:28,940
EXECUTES.

6068
04:02:28,940 --> 04:02:32,010
FINALLY, I'VE BEEN REALLY AMAZED

6069
04:02:32,010 --> 04:02:35,614
BY THE WORK KAREEM DOES IN HIS

6070
04:02:35,614 --> 04:02:37,249
LAB, A NEUROSURGEON WHO TAKES

6071
04:02:37,249 --> 04:02:42,821
ADVANTAGE OF THE ACCESS HE HAS

6072
04:02:42,821 --> 04:02:45,791
AS A NEUROSURGEON TO STUDY THE

6073
04:02:45,791 --> 04:02:47,993
ORGANIZATION AND FUNCTION OF THE

6074
04:02:47,993 --> 04:02:51,063
HUMAN CORTEX, BUT ANOTHER PART

6075
04:02:51,063 --> 04:02:54,232
OF THAT IS TAKING ADVANTAGE OF

6076
04:02:54,232 --> 04:02:59,371
THE RECORDINGS THEY CAN MAKE

6077
04:02:59,371 --> 04:03:03,508
WITH EEG ELECTRODES TO WORK TO

6078
04:03:03,508 --> 04:03:07,145
ISOLATE MORE ACCURATELY THE

6079
04:03:07,145 --> 04:03:08,347
LOCATION OF EPILEPTIC SEIZURE

6080
04:03:08,347 --> 04:03:08,914
FOCI.

6081
04:03:08,914 --> 04:03:17,556
HE'S DOING THIS IN COLLABORATION

6082
04:03:17,556 --> 04:03:19,725
WITH SARAH INATI, AND THE KEY

6083
04:03:19,725 --> 04:03:24,463
HERE IS THAT YOU -- IF YOU HAVE

6084
04:03:24,463 --> 04:03:27,299
A SEIZURE FOCUS, THE EEG

6085
04:03:27,299 --> 04:03:30,168
SIGNATURE OF THESE ARRIVES AT

6086
04:03:30,168 --> 04:03:31,370
DIFFERENT ELECTRODES WITH

6087
04:03:31,370 --> 04:03:31,770
DIFFERENT DELAYS.

6088
04:03:31,770 --> 04:03:33,672
AND SO YOU OUGHT TO BE ABLE,

6089
04:03:33,672 --> 04:03:41,313
IT'S NOT TRIVIAL, BUT YOU CAN

6090
04:03:41,313 --> 04:03:46,785
LOCALIZE THE LOCATION OF THE

6091
04:03:46,785 --> 04:03:49,621
FOCUS BY RELATIVE ARRIVAL OF POP

6092
04:03:49,621 --> 04:03:50,956
GATING WAVES AT DIFFERENT

6093
04:03:50,956 --> 04:03:51,590
ELECTRODES.

6094
04:03:51,590 --> 04:03:53,759
AND ONE OF THE INTERESTING

6095
04:03:53,759 --> 04:03:54,893
THINGS IS THAT THEY HAVE SHOWN

6096
04:03:54,893 --> 04:03:57,763
BY DOING THIS KIND OF ANALYSIS

6097
04:03:57,763 --> 04:04:03,101
THAT THEY CAN MORE ACCURATELY

6098
04:04:03,101 --> 04:04:04,870
LOCATE THE ORIGIN OF THE

6099
04:04:04,870 --> 04:04:07,172
ACTIVITY THAT THEY RECORD ON THE

6100
04:04:07,172 --> 04:04:11,343
ELECTRODES AND THEY HAVE ALSO

6101
04:04:11,343 --> 04:04:13,645
SHOWN THE ENTERICTAL ACTIVITY IS

6102
04:04:13,645 --> 04:04:22,521
ARISING FROM THE SAME SOURCES AS

6103
04:04:22,521 --> 04:04:23,422
SEIZURE ACTIVITY.

6104
04:04:23,422 --> 04:04:25,257
THIS WILL HELP IDENTIFY FOCUS

6105
04:04:25,257 --> 04:04:27,225
AND GUIDE SURGERY BECAUSE IT'S

6106
04:04:27,225 --> 04:04:29,194
CLEAR THAT -- I GUESS RIGHT NOW

6107
04:04:29,194 --> 04:04:32,030
THEY ARE DOING THIS ANALYSIS OF

6108
04:04:32,030 --> 04:04:33,999
THE LOCATION POST HOC, AFTER THE

6109
04:04:33,999 --> 04:04:36,201
SURGERY, BUT WHAT THEY ARE

6110
04:04:36,201 --> 04:04:41,006
FINDING IS THAT WHEN THEY MAKE A

6111
04:04:41,006 --> 04:04:45,043
RESECTION, THIS IS DRUG

6112
04:04:45,043 --> 04:04:46,711
RESISTANT EPILEPSY PATIENTS,

6113
04:04:46,711 --> 04:04:50,282
RESECTION TURNS OUT TO BE WITHIN

6114
04:04:50,282 --> 04:04:52,150
THE AREA OF WHERE THEY

6115
04:04:52,150 --> 04:04:54,352
IDENTIFIED THE SOURCE, THEY HAVE

6116
04:04:54,352 --> 04:04:56,221
A BETTER OUTCOME WITH THE

6117
04:04:56,221 --> 04:04:58,657
PATIENT THAN IF THERE'S NOT AN

6118
04:04:58,657 --> 04:05:06,298
OVERLAP BETWEEN WHERE THEY DID

6119
04:05:06,298 --> 04:05:07,165
THE RESECTION.

6120
04:05:07,165 --> 04:05:09,601
THIS IS SOMETHING KAREEM AND

6121
04:05:09,601 --> 04:05:12,304
SARA HAVE BEEN COLLABORATORS FOR

6122
04:05:12,304 --> 04:05:16,041
A LONG TIME, SARA WAS A STAFF

6123
04:05:16,041 --> 04:05:16,808
CLINICIAN IN THE INSTITUTE

6124
04:05:16,808 --> 04:05:19,978
BEFORE HIM AND I'M EXCITED TO

6125
04:05:19,978 --> 04:05:21,613
SEE HER BRANCH OUT, STILL

6126
04:05:21,613 --> 04:05:24,783
WORKING WITH KAREEM BUT ALSO

6127
04:05:24,783 --> 04:05:26,218
ESTABLISHING HER OWN RESEARCH

6128
04:05:26,218 --> 04:05:29,688
PROGRAM, JUST A CLINICAL

6129
04:05:29,688 --> 04:05:30,021
INVESTIGATOR.

6130
04:05:30,021 --> 04:05:31,356
I'LL STOP THERE.

6131
04:05:31,356 --> 04:05:35,927
AND I'M HAPPY TO -- I WANTED TO

6132
04:05:35,927 --> 04:05:37,562
LEAVE TIME FOR ANY DISCUSSIONS.

6133
04:05:37,562 --> 04:05:40,532
I KNOW IT'S LATE IN THE DAY.

6134
04:05:40,532 --> 04:05:45,270
AND YOU GUYS PROBABLY ARE WIPED

6135
04:05:45,270 --> 04:05:46,071
OUT.

6136
04:05:46,071 --> 04:05:46,671
BUT, YES?

6137
04:05:46,671 --> 04:05:47,973
>> QUICKLY, LOVED HEARING
ABOUT

6138
04:05:47,973 --> 04:05:49,841
THE SCIENCE BUT A QUESTION ABOUT

6139
04:05:49,841 --> 04:05:50,876
CLINICAL INVESTIGATORS.

6140
04:05:50,876 --> 04:05:53,612
WE HEARD FROM WALTER EARLY ON

6141
04:05:53,612 --> 04:05:55,013
ABOUT THE CLINICAL TRANSLATION

6142
04:05:55,013 --> 04:05:57,516
PROGRAM FOR ALZHEIMER'S AND

6143
04:05:57,516 --> 04:05:59,050
RELATED DEMENTIAS, I ASSUME

6144
04:05:59,050 --> 04:06:00,285
THERE WOULD BE CLINICAL

6145
04:06:00,285 --> 04:06:01,686
INVESTIGATORS PART OF THAT.

6146
04:06:01,686 --> 04:06:03,655
WOULD THEY BE WITHIN NINDS UNDER

6147
04:06:03,655 --> 04:06:11,563
YOUR PURVIEW OR NIA? 

6148
04:06:11,563 --> 04:06:13,431
>> MOST OF THE FUNDING IS
COMING

6149
04:06:13,431 --> 04:06:16,568
FROM NIA.

6150
04:06:16,568 --> 04:06:19,671
THEY HAVE BEEN REALLY WELCOMING 

6151
04:06:19,671 --> 04:06:21,706
AND WANTING US TO PARTNER, YOU

6152
04:06:21,706 --> 04:06:24,276
KNOW, AS EQUALS MAKING THE

6153
04:06:24,276 --> 04:06:24,576
DECISION.

6154
04:06:24,576 --> 04:06:27,646
WE HAVE A LOT OF MEETINGS WITH

6155
04:06:27,646 --> 04:06:30,148
THEM TO PLAN THIS.

6156
04:06:30,148 --> 04:06:32,918
SO, I THINK THE CLINICAL PART OF

6157
04:06:32,918 --> 04:06:35,620
THAT WILL SHALL WE WILL HAVE A

6158
04:06:35,620 --> 04:06:40,325
LOT OF INVOLVEMENT IN THAT.

6159
04:06:40,325 --> 04:06:40,759
>> GREAT.

6160
04:06:40,759 --> 04:06:44,462
THAT WHOLE EFFORT IS VERY

6161
04:06:44,462 --> 04:06:46,398
EXCITING, THE CLINICAL PART IS

6162
04:06:46,398 --> 04:06:46,998
COMING ALONG.

6163
04:06:46,998 --> 04:06:50,402
AND THE MODEL THAT CARD USES TO

6164
04:06:50,402 --> 04:06:54,973
TAKE ON NEW PROJECTS AND TO

6165
04:06:54,973 --> 04:06:56,841
PARTNER WITH INVESTIGATORS WHO

6166
04:06:56,841 --> 04:07:00,779
HAVE NEW IDEAS IS -- IT'S VERY

6167
04:07:00,779 --> 04:07:01,012
COOL.

6168
04:07:01,012 --> 04:07:03,014
ANDY SINGLETON IS THE DIRECTOR

6169
04:07:03,014 --> 04:07:04,749
OF CARD.

6170
04:07:04,749 --> 04:07:07,819
I REALLY LIKE THE ENERGY AND

6171
04:07:07,819 --> 04:07:09,888
IDEAS HE'S BRINGING.

6172
04:07:09,888 --> 04:07:11,022
>> I ADD THE AGING
INSTITUTE'S

6173
04:07:11,022 --> 04:07:14,626
CLINICAL PROGRAM IS IN

6174
04:07:14,626 --> 04:07:14,893
BALTIMORE.

6175
04:07:14,893 --> 04:07:18,396
SO THIS ONE, I THINK IT WILL BE

6176
04:07:18,396 --> 04:07:20,098
LIKELY SUPPORTED BY THE NINDS

6177
04:07:20,098 --> 04:07:29,641
CLINICAL PROGRAM IN BETHESDA. 

6178
04:07:29,641 --> 04:07:29,941
>> THANKS.

6179
04:07:29,941 --> 04:07:32,577
SINCE WE DID GET YOU THIS CHOICE

6180
04:07:32,577 --> 04:07:37,115
SPOT I ASSUME YOU'LL BE DROPPING

6181
04:07:37,115 --> 04:07:38,750
MY VALENTINE OFF LATER TONIGHT?

6182
04:07:38,750 --> 04:07:40,685
>> YEAH, IF YOU WANT TO
CALL IT

6183
04:07:40,685 --> 04:07:40,885
THAT.

6184
04:07:40,885 --> 04:07:42,120
[LAUGHTER]

6185
04:07:42,120 --> 04:07:43,521
>> I BELIEVE THAT BRINGS
US TO

6186
04:07:43,521 --> 04:07:47,892
THE FINAL WORD. 

6187
04:07:47,892 --> 04:07:48,126
WALTER?

6188
04:07:48,126 --> 04:07:48,893
FINAL WORD?

6189
04:07:48,893 --> 04:07:53,264
>> I GUESS THE FINAL WORD
IS

6190
04:07:53,264 --> 04:07:54,366
PRAY AND VOTE.

6191
04:07:54,366 --> 04:07:56,668
I GUESS.

6192
04:07:56,668 --> 04:07:57,636
TWO WORDS.

6193
04:07:57,636 --> 04:07:59,404
AND I THINK JEFF, JEFF DIDN'T

6194
04:07:59,404 --> 04:08:02,240
MENTION, BUT WE TALKED ABOUT THE

6195
04:08:02,240 --> 04:08:02,474
BUDGET.

6196
04:08:02,474 --> 04:08:06,845
AND THEY HAVE A LOT LESS LEEWAY

6197
04:08:06,845 --> 04:08:10,782
TO DEAL WITH THE BUDGET CUTS

6198
04:08:10,782 --> 04:08:12,283
THAN ANYBODY ELSE.

6199
04:08:12,283 --> 04:08:14,719
HOPING THE BUDGET COMES THROUGH

6200
04:08:14,719 --> 04:08:16,788
FOR ALLOWING NINDS TO MARCH

6201
04:08:16,788 --> 04:08:17,122
FORWARD.

6202
04:08:17,122 --> 04:08:19,624
I THINK AS YOU CAN TELL, JUST SO

6203
04:08:19,624 --> 04:08:24,229
MUCH GOING ON, IT'S REALLY

6204
04:08:24,229 --> 04:08:26,598
EXCITING TO SEE INTRAMURAL AND

6205
04:08:26,598 --> 04:08:28,933
EXTRAMURAL AND NO MATTER WHAT

6206
04:08:28,933 --> 04:08:30,702
HAPPENS WE'RE NOT GOING TO GIVE

6207
04:08:30,702 --> 04:08:31,036
UP.

6208
04:08:31,036 --> 04:08:33,204
WE'LL KEEP PUSHING FORWARD.

6209
04:08:33,204 --> 04:08:35,607
WE APPRECIATE YOUR INPUT AS WE

6210
04:08:35,607 --> 04:08:37,275
MOVE FORWARD FOR SURE.

6211
04:08:37,275 --> 04:08:39,344
AS YOU CAN SEE, LOTS OF THINGS

6212
04:08:39,344 --> 04:08:41,780
WE'RE THINKING ABOUT.

6213
04:08:41,780 --> 04:08:45,050
AND INPUT IS REALLY VALUED.

6214
04:08:45,050 --> 04:08:47,419
FEEL FREE TO E-MAIL, CALL UP,

6215
04:08:47,419 --> 04:08:48,086
WHATEVER.

6216
04:08:48,086 --> 04:08:50,088
HAPPY TO HEAR FROM THE COUNCIL.

6217
04:08:50,088 --> 04:08:52,590
THANKS.

6218
04:08:52,590 --> 04:08:53,892
>> GREAT.

6219
04:08:53,892 --> 04:08:54,259
THANKS.

6220
04:08:54,259 --> 04:08:56,294
WE'LL RECONVENE TOMORROW FOR

6221
04:08:56,294 --> 04:08:56,995
ACTION-PACKED AND EXCITING

6222
04:08:56,995 --> 04:08:58,163
CLOSED SESSION.

6223
04:08:58,163 --> 04:08:59,597
I THANK EVERYONE FOR THEIR TIME

6224
04:08:59,597 --> 04:09:00,031
TONIGHT.

6225
04:09:00,031 --> 04:09:02,133
I'M GOING TO GAVEL US OUT.

6226
04:09:02,133 --> 04:09:04,836
[END OF PROGRAM]

6227
04:09:04,836 --> 04:09:10,875
 

6228
04:09:10,875 --> 04:09:20,919
 

6229
04:09:51,716 --> 04:10:02,127
... THORACOLUMBAR, WITH THE

6230
04:10:52,110 --> 04:11:02,487
RESTORATION OF COMPLETES,

6231
04:11:30,949 --> 04:11:41,426
COMORBIDITY, COMORBIDITIES, WITH