1 00:00:06,091 --> 00:00:10,795 >> GOOD MORNING AND WELCOME AND 2 00:00:10,795 --> 00:00:15,867 COUNCIL MEMBER TO THE 237th 3 00:00:15,867 --> 00:00:17,068 MEETING OF THE NATIONAL 4 00:00:17,068 --> 00:00:17,569 INSTITUTE OF DENTAL AND 5 00:00:17,569 --> 00:00:18,470 CRANIOFACIAL RESEARCH RESEARCH 6 00:00:18,470 --> 00:00:18,937 COUNCIL. 7 00:00:18,937 --> 00:00:20,438 I'M THE EXECUTIVE SECRETARY, 8 00:00:20,438 --> 00:00:21,673 LYNN KING. 9 00:00:21,673 --> 00:00:23,241 THIS MEETING IS BEING HELD 10 00:00:23,241 --> 00:00:24,509 VIRTUALLY VIA ZOOM AND 11 00:00:24,509 --> 00:00:26,945 ACCOMPANYING VIDEOCAST BY THE 12 00:00:26,945 --> 00:00:27,312 PUBLIC. 13 00:00:27,312 --> 00:00:28,580 QUESTIONS OR COMMENTS FROM THE 14 00:00:28,580 --> 00:00:32,283 PUBLIC CAN BE SUBMITTED TO AN 15 00:00:32,283 --> 00:00:32,917 NIDCR E-MAIL ADDRESS THAT WE 16 00:00:32,917 --> 00:00:36,655 WILL POST AT THE END OF THE OPEN 17 00:00:36,655 --> 00:00:37,322 SESSION. 18 00:00:37,322 --> 00:00:39,891 AND COMMENTS ACCEPTED TO 19 00:00:39,891 --> 00:00:42,027 SEPTEMBER 28, 2024. 20 00:00:42,027 --> 00:00:44,362 ZOOM PARTICIPANTS SHOULD MAKE 21 00:00:44,362 --> 00:00:46,631 SURE YOUR MICROPHONES AND VIDEOS 22 00:00:46,631 --> 00:00:48,299 ARE OFF UNLESS YOU ARE SPEAKING 23 00:00:48,299 --> 00:00:50,535 AND WHEN YOU ARE SPEAKING, 24 00:00:50,535 --> 00:00:51,803 PLEASE STATE YOUR NAME SO WE CAN 25 00:00:51,803 --> 00:00:53,571 ENSURE THE ACCURACY OF OUR 26 00:00:53,571 --> 00:00:55,173 MEETING RECORDS. 27 00:00:55,173 --> 00:00:58,777 COUNCIL MEMBERS WHO NEED 28 00:00:58,777 --> 00:00:59,544 TECHNICAL ASSISTANCE CAN REACH 29 00:00:59,544 --> 00:01:01,680 OUT TO JORDANO OR PATRICK AND 30 00:01:01,680 --> 00:01:05,450 THEIR INFORMATION IS THIS THE 31 00:01:05,450 --> 00:01:11,856 CHAT FOR ANY SUPPORT. 32 00:01:11,856 --> 00:01:14,526 AND FIRST THE ORDER OF BUSINESS 33 00:01:14,526 --> 00:01:16,294 IS THE APPROVAL OF THE MEETING 34 00:01:16,294 --> 00:01:17,996 MINUTES OF THE PREVIOUS COUNCIL 35 00:01:17,996 --> 00:01:18,229 MEETING. 36 00:01:18,229 --> 00:01:20,265 THE MAY 2024 MEETING MINUTES 37 00:01:20,265 --> 00:01:23,401 WERE MADE AVAILABLE TO THE 38 00:01:23,401 --> 00:01:23,968 COUNCIL MEMBERS FOR THEIR 39 00:01:23,968 --> 00:01:25,637 VIEWING AND I'D LIKE TO KNOW IF 40 00:01:25,637 --> 00:01:27,672 THERE ARE ANY QUESTIONS OR 41 00:01:27,672 --> 00:01:29,474 COMMENTS ABOUT THE MAY 2024 42 00:01:29,474 --> 00:01:35,447 MINUTES. 43 00:01:35,447 --> 00:01:37,782 IF THERE ARE NO COMMENTS OR 44 00:01:37,782 --> 00:01:39,417 QUESTIONS WOULD A MEMBER OF 45 00:01:39,417 --> 00:01:40,819 COUNCIL LIKE TO MAKE A MOTION TO 46 00:01:40,819 --> 00:01:41,453 APPROVE THE MINUTES. 47 00:01:41,453 --> 00:01:44,155 >> SO MOVED. 48 00:01:44,155 --> 00:01:47,859 >> PAUL AND I'M SORRY, WHO ELSE? 49 00:01:47,859 --> 00:01:49,294 PLEASE STATE YOUR NAME. 50 00:01:49,294 --> 00:01:53,465 >> JOSÉ. 51 00:01:53,465 --> 00:02:03,508 >> AND JOSÉ MORONCONCEPCION. 52 00:02:03,508 --> 00:02:05,410 ALL IN FAVOR. 53 00:02:05,410 --> 00:02:06,978 >> YES. 54 00:02:06,978 --> 00:02:11,449 >> ANY OPPOSED? 55 00:02:11,449 --> 00:02:15,887 I'LL TURN IT OVER TO 56 00:02:15,887 --> 00:02:18,623 DR. WEBB-CYRIAQUE FOR HER 57 00:02:18,623 --> 00:02:23,628 WELCOME AND PRESENTATION OF THE 58 00:02:23,628 --> 00:02:24,395 DIRECTOR'S REPORT. 59 00:02:24,395 --> 00:02:29,868 >> THANK YOU, DR. KING. 60 00:02:29,868 --> 00:02:38,576 MAKE SURE YOU CAN SEE MY SCREEN. 61 00:02:38,576 --> 00:02:42,614 WELCOME EVERYONE TO THE 237th 62 00:02:42,614 --> 00:02:45,850 MEETING OF THE NATIONAL ADVISORY 63 00:02:45,850 --> 00:02:46,484 NATIONAL INSTITUTE OF DENTAL AND 64 00:02:46,484 --> 00:02:47,085 CRANIOFACIAL RESEARCH COUNCIL. 65 00:02:47,085 --> 00:02:50,221 DR. D'SOUZA IS ON LEAVE AND I'M 66 00:02:50,221 --> 00:02:51,122 SERVING AS ACTING DIRECTOR AND 67 00:02:51,122 --> 00:02:58,229 WILL PROVIDE REMARKS TODAY. 68 00:02:58,229 --> 00:03:00,832 TODAY, I'LL SHARE WITH YOU FIRST 69 00:03:00,832 --> 00:03:03,001 UPDATES FROM THE WHITE HOUSE 70 00:03:03,001 --> 00:03:05,470 FROM NIH AND NIDCR AND SECONDLY 71 00:03:05,470 --> 00:03:08,206 SHARE WITH YOU HOW WE AS A FIELD 72 00:03:08,206 --> 00:03:10,308 CAN LEVERAGE DATA AND PRIMARY 73 00:03:10,308 --> 00:03:11,442 CARE TO MOVE TOWARDS ORAL HEALTH 74 00:03:11,442 --> 00:03:13,711 FOR ALL. 75 00:03:13,711 --> 00:03:19,450 AND LATER IN THE DAY, WE'LL HEAR 76 00:03:19,450 --> 00:03:21,586 KEY EXAMPLES OF DATA CARE COMING 77 00:03:21,586 --> 00:03:22,520 TOGETHER TO INFORM DISEASE AND 78 00:03:22,520 --> 00:03:27,592 HEALTH IN THE CONTEXT OF ALL OF 79 00:03:27,592 --> 00:03:36,401 US AND ALSO THE SJOGREN'S STAMP 80 00:03:36,401 --> 00:03:37,502 PROJECT AND HEAR ABOUT 81 00:03:37,502 --> 00:03:38,369 TRANSFORMATIVE INITIATIVES. 82 00:03:38,369 --> 00:03:42,607 SO IT'S A GREAT DAY AND HAPPY TO 83 00:03:42,607 --> 00:03:45,109 SHARE THESE WITH YOU. 84 00:03:45,109 --> 00:03:46,778 FIRST STARTING WITH WHITE HOUSE 85 00:03:46,778 --> 00:03:47,078 INITIATIVES. 86 00:03:47,078 --> 00:03:47,679 ALIGNED WITH THE NATIONAL 87 00:03:47,679 --> 00:03:51,449 STRATEGY FOR WOMEN'S HEALTH, IS 88 00:03:51,449 --> 00:03:53,484 PRESIDENT BIDEN'S EXECUTIVE 89 00:03:53,484 --> 00:03:55,286 ORDER FOCUSSED ON ADVANCING 90 00:03:55,286 --> 00:03:56,688 WOMEN'S RESEARCH AND INNOVATION. 91 00:03:56,688 --> 00:04:01,459 THIS INCLUDES THE STUDY AND 92 00:04:01,459 --> 00:04:04,395 ANALYSIS OF CONDITIONS SPECIFIC 93 00:04:04,395 --> 00:04:12,337 TO WOMEN THAT DISPROPORTIONATELY 94 00:04:12,337 --> 00:04:15,874 AFFECT WOMEN AND THERE'S 95 00:04:15,874 --> 00:04:16,407 INITIATIVES IN PROGRESS 96 00:04:16,407 --> 00:04:17,976 INCLUDING MATERNAL HEALTH AND 97 00:04:17,976 --> 00:04:22,380 THE DOC DEVELOPMENT OF CHILDREN 98 00:04:22,380 --> 00:04:23,781 AND NATIONAL INSTITUTE OF DENTAL 99 00:04:23,781 --> 00:04:24,415 AND CRANIOFACIAL RESEARCH AND 100 00:04:24,415 --> 00:04:29,854 TWO TMD FOCUSSED INITIATIVES AS 101 00:04:29,854 --> 00:04:31,122 TMD IS DISPROPORTIONATELY 102 00:04:31,122 --> 00:04:31,656 OCCURRING IN WOMEN. 103 00:04:31,656 --> 00:04:34,425 FIRST THE COLLABORATIVE FOR 104 00:04:34,425 --> 00:04:36,661 IMPROVING PATIENT-CENTERED 105 00:04:36,661 --> 00:04:38,129 TRANSFORMATIONAL RESEARCH OR 106 00:04:38,129 --> 00:04:41,366 IMPACT AND ALSO FEASIBILITY 107 00:04:41,366 --> 00:04:43,468 STUDIES THAT EXPLORE BOTH 108 00:04:43,468 --> 00:04:51,876 HEALTHY AND DISEASED TMJ JOINTS 109 00:04:51,876 --> 00:04:58,416 USING SINGLE CELL MULTI OMICS 110 00:04:58,416 --> 00:04:58,850 ANALYSIS. 111 00:04:58,850 --> 00:05:00,218 REGARDING THE BUDGET AND UPDATES 112 00:05:00,218 --> 00:05:01,853 I'D LIKE TO SHARE A TIME LINE. 113 00:05:01,853 --> 00:05:06,257 THIS PAST MARCH THE FY25 BUDGET 114 00:05:06,257 --> 00:05:07,792 REQUEST THAT PROVIDES SPENDING 115 00:05:07,792 --> 00:05:11,195 AND POLICY PROPOSALS INCLUDED 116 00:05:11,195 --> 00:05:14,699 INCREASES TO BOTH NIH AT $49.8 117 00:05:14,699 --> 00:05:19,404 BILLION AN INCREASE OF $1.25 118 00:05:19,404 --> 00:05:22,974 BILLION AND TO NIDCR AT $521 119 00:05:22,974 --> 00:05:28,579 BILLION WHICH WOULD BE AN 120 00:05:28,579 --> 00:05:31,516 INCREASE OF $1.53 MILLION. 121 00:05:31,516 --> 00:05:33,484 THAT WAS PRESIDENT BIDEN'S PLAN. 122 00:05:33,484 --> 00:05:34,585 IN MAY THERE WAS A BUDGET 123 00:05:34,585 --> 00:05:37,422 HEARING BY THE SENATE 124 00:05:37,422 --> 00:05:38,756 APPROPRIATIONS WHERE SEVERAL OF 125 00:05:38,756 --> 00:05:39,958 THE LARGER I.C.s PRESENTED OR 126 00:05:39,958 --> 00:05:43,928 PARTICIPATED. 127 00:05:43,928 --> 00:05:49,434 IN JULY THE HOUSE PROPOSED A 128 00:05:49,434 --> 00:05:50,535 $48.5 BILLION FLAT BUDGET FOR 129 00:05:50,535 --> 00:05:54,172 NIH AND PROPOSED SEVERAL REFORM 130 00:05:54,172 --> 00:05:57,775 POLICIES THAT WILL SUGGEST AN 131 00:05:57,775 --> 00:06:05,149 NIH RESTRUCTURE TO FORM AN 132 00:06:05,149 --> 00:06:05,750 INSTITUTE FOCUSSED ON 133 00:06:05,750 --> 00:06:07,885 NEUROSCIENCE AND BRAIN RESEARCH. 134 00:06:07,885 --> 00:06:11,489 IN AUGUST, THE SENATE 135 00:06:11,489 --> 00:06:20,531 APPROPRIATIONS PROPOSED A $53.5 136 00:06:20,531 --> 00:06:21,933 BILLION AN INCREASE TO NIH AND 137 00:06:21,933 --> 00:06:23,901 FLAT BUDGET TO NIDCR WHERE WHERE 138 00:06:23,901 --> 00:06:24,869 HE WOULD CONTINUE AT FY24 139 00:06:24,869 --> 00:06:29,474 LEVELS. 140 00:06:29,474 --> 00:06:31,642 RIGHT NOW THERE'S A POTENTIAL 141 00:06:31,642 --> 00:06:32,477 CONTINUING RESOLUTION BEING 142 00:06:32,477 --> 00:06:34,712 WORKED ON TO FUND THE FULL 143 00:06:34,712 --> 00:06:37,015 GOVERNMENT AT FY24. 144 00:06:37,015 --> 00:06:39,350 HOT OFF THE PRESS YESTERDAY, THE 145 00:06:39,350 --> 00:06:41,285 HOUSE PASSED A RULE THAT WOULD 146 00:06:41,285 --> 00:06:49,394 ALLOW THEM TO CONSIDER HR9494 A 147 00:06:49,394 --> 00:06:50,561 HOUSE GOP SUPPORTED CONTINUING 148 00:06:50,561 --> 00:06:53,131 RESOLUTION EXTENDING GOVERNMENT 149 00:06:53,131 --> 00:06:53,731 FUNDING THROUGH NEXT MARCH OF 150 00:06:53,731 --> 00:06:58,169 2025. 151 00:06:58,169 --> 00:06:59,303 RIGHT AFTER THE BIDEN 152 00:06:59,303 --> 00:07:01,305 ADMINISTRATION RELEASED A 153 00:07:01,305 --> 00:07:06,844 STATEMENT OF ADMINISTRATIVE 154 00:07:06,844 --> 00:07:09,647 POLICY SAID IT WOULD LIKELY BE 155 00:07:09,647 --> 00:07:12,250 VETOED IF PASSED AND THERE WAS 156 00:07:12,250 --> 00:07:13,151 ADDITIONAL CRITIQUE OF THAT 157 00:07:13,151 --> 00:07:13,718 PROPOSAL. 158 00:07:13,718 --> 00:07:17,955 THE HOUSE IS PROJECTED TO VOTE 159 00:07:17,955 --> 00:07:21,959 TODAY ON HR9494 AND WE'LL SEE 160 00:07:21,959 --> 00:07:29,133 WHAT HAPPENS ON THE HOUSE FLOOR. 161 00:07:29,133 --> 00:07:30,968 THIS YEAR FINAL APPROPRIATIONS 162 00:07:30,968 --> 00:07:36,274 AGAIN JUST TO REITERATE WILL BE 163 00:07:36,274 --> 00:07:40,611 $48.9 BILLION FOR NIH AN OVER 164 00:07:40,611 --> 00:07:48,886 ALL 1% INCREASE AND $520 MILLION 165 00:07:48,886 --> 00:07:51,889 NO INCREASE TO US. 166 00:07:51,889 --> 00:07:53,558 OVER $400 MILLION OF THAT OR 167 00:07:53,558 --> 00:07:58,129 CLOSE TO 80% GOES TO EXTRAMURAL. 168 00:07:58,129 --> 00:08:01,032 ABOUT 14.5% GOES TO INTRAMURAL 169 00:08:01,032 --> 00:08:05,670 SCIENCE AND THE REMAINDER GOES 170 00:08:05,670 --> 00:08:08,372 TO RESEARCH MANAGEMENT OF 6% TO 171 00:08:08,372 --> 00:08:11,142 KEEP OUR LIGHTS ON. 172 00:08:11,142 --> 00:08:14,846 IF WE LOOK MORE CLOSELY AT THE 173 00:08:14,846 --> 00:08:16,747 TWO CHARTS THAT DEMONSTRATE OUR 174 00:08:16,747 --> 00:08:17,882 EXTRAMURAL SPENDING IN 2023 175 00:08:17,882 --> 00:08:20,985 YOU'LL SEE ABOUT 80% GOES TO 176 00:08:20,985 --> 00:08:22,153 THESE RESEARCH PROJECT GRANTS 177 00:08:22,153 --> 00:08:26,891 AND OF THAT 80% THIS OTHER PIE 178 00:08:26,891 --> 00:08:31,896 CHART ON YOUR RIGHT YOU SEE 60% 179 00:08:31,896 --> 00:08:35,500 IS COVERING GRANT OUT YEARS AND 180 00:08:35,500 --> 00:08:42,473 OF THE REMAINING 20%, 4% GOES TO 181 00:08:42,473 --> 00:08:45,176 RFAs AND THERE'S FOURFOLD HIGHER 182 00:08:45,176 --> 00:08:50,515 FUNDING THAT OCCURS AT 16% TO 183 00:08:50,515 --> 00:08:53,217 INVESTIGATOR INITIATED RPGs AND 184 00:08:53,217 --> 00:08:54,652 1% FOR SUPPLEMENTS. 185 00:08:54,652 --> 00:08:56,888 WE LOOK AT THE LARGER PIE. 186 00:08:56,888 --> 00:08:59,056 WE JUST TALKED ABOUT RESEARCH 187 00:08:59,056 --> 00:08:59,891 PROJECT GRANTS. 188 00:08:59,891 --> 00:09:02,026 WE HAVE ABOUT 6% THAT GOES TO 189 00:09:02,026 --> 00:09:03,427 CAREERS AND TRAINING AND ANOTHER 190 00:09:03,427 --> 00:09:07,899 6% THAT GOES TO CONTRACTS, 2% TO 191 00:09:07,899 --> 00:09:11,269 CENTERS AND ABOUT 3% TO SMALL 192 00:09:11,269 --> 00:09:21,712 BUSINESS AND STTR EFFORTS. 193 00:09:22,280 --> 00:09:25,983 EVEN WITH THE HIGHER 194 00:09:25,983 --> 00:09:29,487 APPROPRIATION AT 2023 OUR 195 00:09:29,487 --> 00:09:34,192 PURCHASING POWER COUCHED IN 2019 196 00:09:34,192 --> 00:09:36,027 DOLLARS IS ACTUALLY CONSIDERABLY 197 00:09:36,027 --> 00:09:36,827 LOWER. 198 00:09:36,827 --> 00:09:38,729 OUR PURCHASING POWER HAS 199 00:09:38,729 --> 00:09:39,897 DECREASED SINCE 2021 HERE AT 200 00:09:39,897 --> 00:09:46,070 NIDCR. 201 00:09:46,070 --> 00:09:47,505 WE'VE BEEN ABLE TO MAINTAIN 202 00:09:47,505 --> 00:09:49,106 SUCCESSION RATES OVER THE PAST 203 00:09:49,106 --> 00:09:50,741 FIVE YEARS THAT HAVE BEEN 204 00:09:50,741 --> 00:09:55,379 COMPARABLE OR HIGHER TO NIH. 205 00:09:55,379 --> 00:09:57,081 AND WE REMAIN THE MAJOR FUNDER 206 00:09:57,081 --> 00:09:59,650 OF DENTAL SCHOOLS AT 63% AND 207 00:09:59,650 --> 00:10:02,119 THIS ACCOUNTS FOR JUST UNDER 208 00:10:02,119 --> 00:10:03,888 HALF OF OUR EXTRAMURAL BUDGET AT 209 00:10:03,888 --> 00:10:05,690 44%. 210 00:10:05,690 --> 00:10:07,425 SO WE'RE PROUD OF THAT. 211 00:10:07,425 --> 00:10:11,329 AND WE CAN ACTUALLY SEE THAT 212 00:10:11,329 --> 00:10:15,233 FROM 2021 WE'VE HAD AN INCREASE 213 00:10:15,233 --> 00:10:18,903 IN NIDCR FUNDING TO SCHOOLS. 214 00:10:18,903 --> 00:10:22,740 SO WHAT'S HAPPENING AT NIH? 215 00:10:22,740 --> 00:10:25,042 NIH IS WORKING TO DEVELOP A 216 00:10:25,042 --> 00:10:27,912 VISION AND FRAMEWORK TO 217 00:10:27,912 --> 00:10:29,247 INCORPORATE PUBLIC VOICES ACROSS 218 00:10:29,247 --> 00:10:31,882 ALL PHASES AND TYPES OF CLINICAL 219 00:10:31,882 --> 00:10:33,551 RESEARCH AND THIS PARTNERSHIP 220 00:10:33,551 --> 00:10:36,487 WITH THE PUBLIC IS CALLED ENGAGE 221 00:10:36,487 --> 00:10:39,890 AND THE RFI GATHERED INFORMATION 222 00:10:39,890 --> 00:10:42,727 ON HOW BEST TO MAXIMIZE PUBLIC 223 00:10:42,727 --> 00:10:43,728 ENGAGEMENT THIS PAST SUMMER AND 224 00:10:43,728 --> 00:10:46,163 I WANT TO THANK YOU TO ALL OF 225 00:10:46,163 --> 00:10:51,335 YOU WHO SHARED YOUR THOUGHTS AS 226 00:10:51,335 --> 00:10:53,137 IT REALLY IS THE THOUGHTS THAT 227 00:10:53,137 --> 00:10:54,405 WILL HELP US ASSURE RESEARCH 228 00:10:54,405 --> 00:10:58,376 KEEPS THE PATIENT AT THE CENTER. 229 00:10:58,376 --> 00:11:01,846 THE CHANGE IN REVIEW IS QUICKLY 230 00:11:01,846 --> 00:11:03,748 APPROACHING AS GRANT REVIEW IS 231 00:11:03,748 --> 00:11:06,083 GOING TO MOVE FROM FIVE 232 00:11:06,083 --> 00:11:10,421 REGULATORY CRITERIA TO THREE 233 00:11:10,421 --> 00:11:13,090 REGULATORY CRITERIA AFTER 234 00:11:13,090 --> 00:11:13,858 JANUARY 25. 235 00:11:13,858 --> 00:11:16,861 THIS WILL FOCUS ON THREE AREAS. 236 00:11:16,861 --> 00:11:18,996 THE FIRST BEING THE IMPORTANCE 237 00:11:18,996 --> 00:11:20,398 OF RESEARCH SIGNIFICANCE AND 238 00:11:20,398 --> 00:11:22,199 INNOVATION THAT WILL BE SCORED. 239 00:11:22,199 --> 00:11:25,102 THE SECOND ON RIGOR AND 240 00:11:25,102 --> 00:11:27,805 FEASIBILITY, THAT'S THE 241 00:11:27,805 --> 00:11:28,673 APPROACH, THAT WILL BE SCORED 242 00:11:28,673 --> 00:11:31,342 AND THE THIRD AND FINAL ONE IS 243 00:11:31,342 --> 00:11:34,979 EXPERTISE AND RESOURCES FORMALLY 244 00:11:34,979 --> 00:11:36,514 INVESTIGATOR AND ENVIRONMENT. 245 00:11:36,514 --> 00:11:38,249 THIS WILL NOT BE INDIVIDUALLY 246 00:11:38,249 --> 00:11:39,483 SCORED BUT CONSIDERED AN OVER 247 00:11:39,483 --> 00:11:40,851 ALL IMPACT. 248 00:11:40,851 --> 00:11:42,453 SO THAT'S UPCOMING. 249 00:11:42,453 --> 00:11:44,989 NOT FOR THIS CURRENT CYCLE FOR 250 00:11:44,989 --> 00:11:47,491 OCTOBER GRANTS BUT IT WILL BEGIN 251 00:11:47,491 --> 00:11:50,194 IN JANUARY. 252 00:11:50,194 --> 00:11:51,896 THE NIH OFFICE OF SCIENCE POLICY 253 00:11:51,896 --> 00:11:55,466 HAS RECENTLY UNVEILED A REALLY 254 00:11:55,466 --> 00:11:56,634 VALUABLE RESOURCE FOCUSSED ON 255 00:11:56,634 --> 00:11:59,503 ARTIFICIAL INTELLIGENCE 256 00:11:59,503 --> 00:11:59,770 RESEARCH. 257 00:11:59,770 --> 00:12:02,173 AND SO THERE'S GUIDANCE HERE. 258 00:12:02,173 --> 00:12:05,343 AND THIS RESOURCE IS DESIGNED TO 259 00:12:05,343 --> 00:12:07,144 RESPONSIBLY GUIDE AND GOVERN 260 00:12:07,144 --> 00:12:08,746 ADVANCING SCIENCE AND EMERGING 261 00:12:08,746 --> 00:12:10,114 TECHNOLOGIES INCLUDING THE 262 00:12:10,114 --> 00:12:12,516 DEVELOPMENT AND USE OF A.I. IN 263 00:12:12,516 --> 00:12:15,886 RESEARCH AND YOU'LL SEE THE QR 264 00:12:15,886 --> 00:12:21,926 CODE IS HERE. 265 00:12:21,926 --> 00:12:25,496 AS AN FYI, THERE'S A POSITION 266 00:12:25,496 --> 00:12:27,898 OPEN AT THE NATIONAL INSTITUTE 267 00:12:27,898 --> 00:12:29,700 OF ARTHRITIS, MUSCULOSKELETAL 268 00:12:29,700 --> 00:12:31,702 AND SKIN DISEASES. 269 00:12:31,702 --> 00:12:33,704 I'M SHARING THIS BECAUSE OF THE 270 00:12:33,704 --> 00:12:37,007 MANY AREAS OF OVERLAP ACROSS OUR 271 00:12:37,007 --> 00:12:37,308 INSTITUTES. 272 00:12:37,308 --> 00:12:39,744 THE POSITION IS FOR DEPUTY 273 00:12:39,744 --> 00:12:40,711 DIRECTOR AND APPLICATIONS ARE 274 00:12:40,711 --> 00:12:43,114 DUE AT THE END OF THE MONTH. 275 00:12:43,114 --> 00:12:45,015 SO PLEASE SEE THE WEBSITE IF YOU 276 00:12:45,015 --> 00:12:48,719 HAVE AN INTEREST OR CONTACT 277 00:12:48,719 --> 00:12:50,821 BRENDA FOGGAL WITH ANY QUESTIONS 278 00:12:50,821 --> 00:12:55,226 AT THIS ADDRESS HERE.EGAL WITH 279 00:12:55,226 --> 00:12:56,193 QUESTIONS AT THIS ADDRESS HERE.S 280 00:12:56,193 --> 00:12:56,994 AT THIS ADDRESS HERE.L WITH ANY 281 00:12:56,994 --> 00:12:58,162 AT THIS ADDRESS HERE. 282 00:12:58,162 --> 00:13:02,366 IN TERMS OF STAFF UPDATES, 283 00:13:02,366 --> 00:13:04,835 MICHAEL COLLINS, DR. COLLINS 284 00:13:04,835 --> 00:13:06,871 RETIRED THIS SUMMER AT 25 YEARS 285 00:13:06,871 --> 00:13:08,439 AT NIH. 286 00:13:08,439 --> 00:13:11,008 HE'S A WONDERFUL MENTOR AND LED 287 00:13:11,008 --> 00:13:15,546 THE SKELETAL DISORDERS AND 288 00:13:15,546 --> 00:13:17,681 MINERAL HOMEOSTASIS SECTION AND 289 00:13:17,681 --> 00:13:19,850 IS A LEADER IN THE AREA OF 290 00:13:19,850 --> 00:13:23,487 TRANSLATIONAL BONE BIOLOGY. 291 00:13:23,487 --> 00:13:23,854 THANK YOU, MIKE. 292 00:13:23,854 --> 00:13:33,330 WE HAVE A SPECIAL REMEMBRANCE TO 293 00:13:33,330 --> 00:13:38,135 TERRIE COWLEY WHO RECENTLY 294 00:13:38,135 --> 00:13:40,971 PASSED THE FOUNDER OF THE TMJ 295 00:13:40,971 --> 00:13:42,907 ASSOCIATION AND STALWART 296 00:13:42,907 --> 00:13:45,376 SUPPORTER OF TMJ AND WORKED WITH 297 00:13:45,376 --> 00:13:48,145 NIDCR AND FDA TO ESTABLISH ROUND 298 00:13:48,145 --> 00:13:50,114 TABLES AND WHAT SHOW WOULD OFTEN 299 00:13:50,114 --> 00:13:51,348 SHARE WITH MANY OF US IS THAT IF 300 00:13:51,348 --> 00:13:55,186 YOU GOT A DOLLAR, SHE'S GOING TO 301 00:13:55,186 --> 00:14:00,691 ASK FOR A DOLLAR FIFTY AND ASK 302 00:14:00,691 --> 00:14:07,198 EVERY CENT GO TO TMD AND SHE WAS 303 00:14:07,198 --> 00:14:08,566 A FIERCE ADVOCATE AND FORMED THE 304 00:14:08,566 --> 00:14:13,103 CHRONIC OVERLAPPING PAIN ALI 305 00:14:13,103 --> 00:14:14,438 ALIGNING ALLIANCE BRINGING 306 00:14:14,438 --> 00:14:16,006 AWARENESS TO THE CO-OCCURRING 307 00:14:16,006 --> 00:14:19,677 CONDITIONS AND TERRIE KNOW THAT 308 00:14:19,677 --> 00:14:21,078 YOUR DEDICATION WILL NOT BE 309 00:14:21,078 --> 00:14:23,013 FORGOTTEN AND THE WORK WILL 310 00:14:23,013 --> 00:14:25,449 CONTINUE TO WORK TOWARDS RELIEF 311 00:14:25,449 --> 00:14:32,289 FOR THE MANY AFFECTED WITH TMD. 312 00:14:32,289 --> 00:14:36,694 IN TERMS OF INSTITUTE UPDATES, 313 00:14:36,694 --> 00:14:39,296 OUR LEADERSHIP HAS HAD THE 314 00:14:39,296 --> 00:14:40,731 PRIVILEGE TO TAKE PART OF THE 315 00:14:40,731 --> 00:14:41,665 SUMMER RESEARCH DAY AT THE 316 00:14:41,665 --> 00:14:44,301 UNIVERSITY OF MARYLAND AND THE 317 00:14:44,301 --> 00:14:46,437 40th ANNUAL RESEARCH DAY AT THE 318 00:14:46,437 --> 00:14:47,938 INVESTIGATION OF NORTH CAROLINA 319 00:14:47,938 --> 00:14:53,511 SCHOOL OF DENTISTRY AND AT TO 320 00:14:53,511 --> 00:15:01,519 THE A.T. STILL INSTITUTE AND AT 321 00:15:01,519 --> 00:15:02,253 THE UNIVERSITY OF THE UNIVERSITY 322 00:15:02,253 --> 00:15:04,822 PACIFIC FACULTY DEVELOPMENT DAY. 323 00:15:04,822 --> 00:15:07,291 WE ALSO PRESENTED A LUNCH AND 324 00:15:07,291 --> 00:15:11,095 LEARN FOR CONGRESSIONAL STAFF TO 325 00:15:11,095 --> 00:15:12,062 SHARE WITH THEM INFORMATION 326 00:15:12,062 --> 00:15:14,598 AROUND TMD AND ORAL FACIAL PAIN 327 00:15:14,598 --> 00:15:18,869 AND CO-SPONSORED THE DAVID 328 00:15:18,869 --> 00:15:23,741 BARMES LECTURE FOCUSSED ON 329 00:15:23,741 --> 00:15:27,878 GLOBAL HEALTH IF HE TURING 330 00:15:27,878 --> 00:15:29,280 DR. NKENGASONG. 331 00:15:29,280 --> 00:15:31,882 WE PARTICIPATED AT MULTIPLE 332 00:15:31,882 --> 00:15:35,886 NATIONAL MEETINGS INCLUDING THE 333 00:15:35,886 --> 00:15:39,023 NATIONAL DENTAL ASSOCIATION 334 00:15:39,023 --> 00:15:40,891 RESEARCH FORUM, THE HISPANIC 335 00:15:40,891 --> 00:15:42,259 DENTAL ASSOCIATION WORKSHOP AND 336 00:15:42,259 --> 00:15:47,498 THE UNITED STATES PUBLIC HEALTH 337 00:15:47,498 --> 00:15:58,008 SERVICES SCIENTIFIC SYMPOSIUM. 338 00:15:59,577 --> 00:16:04,248 WHAT HAVE WE BEEN UP TO WITH 339 00:16:04,248 --> 00:16:06,383 RFAs AND THE REQUESTS FOR 340 00:16:06,383 --> 00:16:11,889 APPLICATIONS AND CONCEPTS ARE 341 00:16:11,889 --> 00:16:19,129 DRIVEN BY OUR FIVE STRATEGIC 342 00:16:19,129 --> 00:16:20,464 PRIORITIES INTEGRATING ORAL AND 343 00:16:20,464 --> 00:16:22,266 GENERAL HEALTH AND PRECISION 344 00:16:22,266 --> 00:16:23,167 MEDICINE AND TRANSLATION AND 345 00:16:23,167 --> 00:16:26,270 IMPLEMENTATION AND PARTNERING 346 00:16:26,270 --> 00:16:31,542 AND COLLABORATING AND 347 00:16:31,542 --> 00:16:32,576 DIVERSIFYING THE RESEARCH 348 00:16:32,576 --> 00:16:34,678 PATHWAY. 349 00:16:34,678 --> 00:16:37,948 HERE IF WE LOOK BACK AT THE NINE 350 00:16:37,948 --> 00:16:39,883 RFA AWARDS MADE IN 2023 YOU'LL 351 00:16:39,883 --> 00:16:42,853 NOTICE EACH IS ALIGNED WITH 352 00:16:42,853 --> 00:16:47,091 STRATEGIC PRIORITIES THAT ARE 353 00:16:47,091 --> 00:16:52,262 LISTED ON THE RIGHT HAND COLUMN. 354 00:16:52,262 --> 00:16:57,735 SHE'S INCLUDE THE EXAMINATION OF 355 00:16:57,735 --> 00:16:58,736 INTERSECTIONALITY BETWEEN ORAL 356 00:16:58,736 --> 00:17:02,039 HEALTH AND HIV AND PRECISION 357 00:17:02,039 --> 00:17:07,511 APPROACHES TO TREAT INTRACRANIAL 358 00:17:07,511 --> 00:17:08,679 DENTAL CRANIOFACIAL DISORDERS 359 00:17:08,679 --> 00:17:11,382 AND DRIVE THE DEVELOPMENT OF DOC 360 00:17:11,382 --> 00:17:15,419 BIO MATERIALS AND UTILIZING 361 00:17:15,419 --> 00:17:18,389 TECHNOLOGIES TO PROMOTE ORAL 362 00:17:18,389 --> 00:17:21,358 HEALTH AND FINALLY LEVERAGING 363 00:17:21,358 --> 00:17:23,494 DENTISTRY TO PREVENT OPIOID 364 00:17:23,494 --> 00:17:33,637 MISUSE. 365 00:17:36,907 --> 00:17:39,309 AMONG THE SIGNATURE INITIATIVES 366 00:17:39,309 --> 00:17:45,349 IS THE PRIMED INITIATIVE OR 367 00:17:45,349 --> 00:17:47,518 PRACTICED BASED RESEARCH IN 368 00:17:47,518 --> 00:17:51,522 DENTAL SCHOOL BASED PRACTICE 369 00:17:51,522 --> 00:17:52,322 NETWORK. 370 00:17:52,322 --> 00:17:53,724 THE AHEAD PROGRAM TO ADVANCE 371 00:17:53,724 --> 00:17:56,026 HEAD AND NECK CANCER EARLIER 372 00:17:56,026 --> 00:18:01,999 DETECTION RESEARCH. 373 00:18:01,999 --> 00:18:07,905 AND IMPACT FOCUS ON TMJ AND 374 00:18:07,905 --> 00:18:10,140 PATIENT-CENTERED COLLABORATIVE 375 00:18:10,140 --> 00:18:16,080 TOWARDS TREAT BEING TMJ. 376 00:18:16,080 --> 00:18:21,485 CLEARLY WE'RE READY AND PRIMED 377 00:18:21,485 --> 00:18:23,487 TO MOVE AHEAD WITH IMPACT ACROSS 378 00:18:23,487 --> 00:18:24,955 THESE INITIATIVES. 379 00:18:24,955 --> 00:18:28,892 IF WE LOOK AT THE CURRENT RFAs, 380 00:18:28,892 --> 00:18:30,294 FY24, THEY'RE ALSO ALIGNED WITH 381 00:18:30,294 --> 00:18:33,063 OUR STRATEGIC PRIORITIES AND 382 00:18:33,063 --> 00:18:37,101 FOCUS ON EARLIER CANCER AND HPV 383 00:18:37,101 --> 00:18:38,469 CO-INFECTIONS. 384 00:18:38,469 --> 00:18:39,503 OPPORTUNITIES FOR TEAM SCIENCE 385 00:18:39,503 --> 00:18:45,843 THROUGH DISRUPTIVE INNOVATION. 386 00:18:45,843 --> 00:18:47,411 OPPORTUNITIES TO DEVELOP 387 00:18:47,411 --> 00:18:51,215 THERAPEUTICS BASED ON SALIVARY 388 00:18:51,215 --> 00:18:53,350 COMPONENTS AND THE SOAR AWARD 389 00:18:53,350 --> 00:18:55,319 FOR OUTSTANDING ACHIEVEMENT IN 390 00:18:55,319 --> 00:19:05,496 RESEARCH. 391 00:19:07,264 --> 00:19:14,638 FUTURE RFAs AND INITIATIVES ON 392 00:19:14,638 --> 00:19:16,807 THESE WILL BE THROUGH AND 393 00:19:16,807 --> 00:19:19,877 BUILDING MENTORING NETWORKS FOR 394 00:19:19,877 --> 00:19:20,410 UNDER REPRESENTED CAREER 395 00:19:20,410 --> 00:19:26,383 ADVOCATORS. 396 00:19:26,383 --> 00:19:28,952 USING IMAGING TO TREAT ORAL 397 00:19:28,952 --> 00:19:31,588 LESIONS AND TOWARDS TRANSLATION 398 00:19:31,588 --> 00:19:32,990 AND IMPLEMENTATION, FAST 399 00:19:32,990 --> 00:19:33,991 TRACKING PRODUCTS FOR CLINICAL 400 00:19:33,991 --> 00:19:34,525 ADOPTION THROUGH THE APEX 401 00:19:34,525 --> 00:19:39,897 PROGRAM. 402 00:19:39,897 --> 00:19:43,300 THERE'S A FOCUS ON ORAL HIV/AIDS 403 00:19:43,300 --> 00:19:45,135 RESEARCH AND BUILDING ORAL 404 00:19:45,135 --> 00:19:50,240 THERAPEUTICS BASED ON 405 00:19:50,240 --> 00:19:50,908 BACTERIAPHAGE AND UTILIZING OF 406 00:19:50,908 --> 00:19:52,676 COMMUNITY BASED APPROACHES AND 407 00:19:52,676 --> 00:19:53,644 DATA TO ADDRESS ORAL HEALTH 408 00:19:53,644 --> 00:20:00,984 DISPARITIES. 409 00:20:00,984 --> 00:20:02,519 EXAMINING RELATIONSHIP BETWEEN 410 00:20:02,519 --> 00:20:03,654 ORAL HEALTH AND NUTRITION AND 411 00:20:03,654 --> 00:20:06,390 GENERAL HEALTH AND BUILDING WHAT 412 00:20:06,390 --> 00:20:11,495 I'LL CALL AN ORAL ORGANSHIP ON A 413 00:20:11,495 --> 00:20:21,605 CHIP. 414 00:20:21,939 --> 00:20:25,776 IN TERMS OF NEW INITIATIVES 415 00:20:25,776 --> 00:20:27,811 INTERACTION WITH AN NIH WIDE 416 00:20:27,811 --> 00:20:29,513 INITIATIVE TO ADDRESS WHOLE 417 00:20:29,513 --> 00:20:32,316 PERSON HEALTH FROM THE MOLECULAR 418 00:20:32,316 --> 00:20:33,717 TO CELLULAR LEVEL TO ORGAN LEVEL 419 00:20:33,717 --> 00:20:35,285 AND OUT TO THE WHOLE PERSON 420 00:20:35,285 --> 00:20:44,328 BEGINNING WITH THE FIS YOEM. 421 00:20:44,328 --> 00:20:46,396 PHYSIOME AND THIS PARTICULAR 422 00:20:46,396 --> 00:20:50,467 SEEKING APPLICATIONS 20 STRAEB A 423 00:20:50,467 --> 00:20:51,902 WHOLE PERSON RESEARCH AND 424 00:20:51,902 --> 00:20:53,570 COORDINATION CENTER. 425 00:20:53,570 --> 00:20:54,972 AND SO THIS WILL BE A WONDERFUL 426 00:20:54,972 --> 00:21:05,315 WAY TO ENSURE INTEGRATION AND 427 00:21:05,315 --> 00:21:05,949 THE WHOLE PERSON. 428 00:21:05,949 --> 00:21:07,551 THERE'S A DISEASE AGNOSTIC 429 00:21:07,551 --> 00:21:10,854 INITIATIVE THAT PROMOTES 430 00:21:10,854 --> 00:21:13,257 INTEGRATED TEAMS WITH DIVERSE 431 00:21:13,257 --> 00:21:15,826 PERSPECTIVES AND EXPERTISE WHO 432 00:21:15,826 --> 00:21:23,500 TOGETHER CAN BUILD DISRUPTIVE 433 00:21:23,500 --> 00:21:24,268 INNOVATIONS IN CRANIOFACIAL 434 00:21:24,268 --> 00:21:27,971 RESEARCH AND PROBIOTIC 435 00:21:27,971 --> 00:21:28,305 INTERVENTIONS. 436 00:21:28,305 --> 00:21:30,540 THIS ENHANCING MECHANISTIC 437 00:21:30,540 --> 00:21:33,810 RESEARCH ON PRECISION PROBIOTICS 438 00:21:33,810 --> 00:21:34,945 WILL ENHANCE OUTCOMES BY 439 00:21:34,945 --> 00:21:38,015 DETERMINING THE CHARACTERISTICS 440 00:21:38,015 --> 00:21:41,451 OF INDIVIDUALS WHO RESPOND. 441 00:21:41,451 --> 00:21:43,921 SO THIS IS PRECISION MEDICINE 442 00:21:43,921 --> 00:21:45,756 FOR DENTISTRY. 443 00:21:45,756 --> 00:21:51,895 AND IN THE CONTEXT OF THE 444 00:21:51,895 --> 00:21:55,866 HELPING TO END ADDICTION 445 00:21:55,866 --> 00:21:58,969 LONG-TERM, THERE ARE SEVERAL 446 00:21:58,969 --> 00:22:00,037 INITIATIVES COMING UP INCLUDING 447 00:22:00,037 --> 00:22:02,572 THE INTERACT INITIATIVE FOCUSSED 448 00:22:02,572 --> 00:22:04,274 ON BACK PAIN. 449 00:22:04,274 --> 00:22:07,377 THERE'S A HEAL KIDS PROGRAM 450 00:22:07,377 --> 00:22:09,646 WHERE KIDS STANDS FOR KNOWLEDGE 451 00:22:09,646 --> 00:22:11,481 INNOVATION AND DISCOVERY STUDIES 452 00:22:11,481 --> 00:22:13,083 FOCUSES ON CHRONIC PAIN, THERE'S 453 00:22:13,083 --> 00:22:15,218 A MENTORED CLINICAL SCIENTIST 454 00:22:15,218 --> 00:22:21,258 AWARDS THAT ARE FOCUSSED ON PAIN 455 00:22:21,258 --> 00:22:25,262 AND TRANSLATION OF DIAGNOSTIC 456 00:22:25,262 --> 00:22:29,499 AND THERAPEUTIC DEVICES THROUGH 457 00:22:29,499 --> 00:22:32,035 BLUEPRINT MED TECH. 458 00:22:32,035 --> 00:22:34,071 UPCOMING NOTICES OF SPECIAL 459 00:22:34,071 --> 00:22:37,741 INTEREST INCLUDE TMD IMPACT, 460 00:22:37,741 --> 00:22:43,914 THERE'S A NOSI ON WOMEN'S HEALTH 461 00:22:43,914 --> 00:22:49,319 RESEARCH ONE ON PHAGE BIOLOGY 462 00:22:49,319 --> 00:22:53,256 AND UNDERSTANDING ADVERSE EVENTS 463 00:22:53,256 --> 00:22:55,592 IN THE CONTEXT OF CANCER 464 00:22:55,592 --> 00:22:55,892 THERAPY. 465 00:22:55,892 --> 00:22:59,496 WHAT'S HAPPENING WITH REGARD TO 466 00:22:59,496 --> 00:23:02,032 OUR FIELD AS WE CONSIDER GROWING 467 00:23:02,032 --> 00:23:03,533 THE FIELD. 468 00:23:03,533 --> 00:23:06,503 I'M PLEASED TO SHARE WITH YOU 469 00:23:06,503 --> 00:23:09,639 SEVERAL OPPORTUNITIES. 470 00:23:09,639 --> 00:23:11,341 THE FIRST IS NIDCR'S PUBLIC 471 00:23:11,341 --> 00:23:12,376 HEALTH RESEARCH PROGRAM. 472 00:23:12,376 --> 00:23:15,178 IT'S A THREE-YEAR PROGRAM THAT 473 00:23:15,178 --> 00:23:19,149 INCLUDES 12-MONTH FULL TIME 474 00:23:19,149 --> 00:23:20,283 RESIDENCY IN DENTAL PUBLIC 475 00:23:20,283 --> 00:23:25,288 HEALTH FOLLOWED BY A 24-MONTH 476 00:23:25,288 --> 00:23:26,857 POSTDOCTORAL RESEARCH 477 00:23:26,857 --> 00:23:27,157 FELLOWSHIP. 478 00:23:27,157 --> 00:23:29,726 HERE ARE OUR FIRST-YEAR FELLOWS 479 00:23:29,726 --> 00:23:33,163 WHO RECENTLY COMPLETED THE 480 00:23:33,163 --> 00:23:35,432 DEN 481 00:23:35,432 --> 00:23:39,069 DENTAL PUBLIC HEALTH RESIDENCY 482 00:23:39,069 --> 00:23:41,738 ON ORAL CANCER AND PRECANCER AND 483 00:23:41,738 --> 00:23:44,674 HPV RISK RELATED PERCEPTION AND 484 00:23:44,674 --> 00:23:48,378 DENTAL CARE UTILIZATION AMONG 485 00:23:48,378 --> 00:23:51,915 SEXUAL GENDER MINORITY 486 00:23:51,915 --> 00:23:57,421 POPULATIONS. 487 00:23:57,421 --> 00:23:59,389 AND THIRD YEAR AS THEY BECOME 488 00:23:59,389 --> 00:24:03,894 THOUGHT LEADERS IN COLLABORATION 489 00:24:03,894 --> 00:24:14,337 WITH OTHER NIH INSTITUTES. 490 00:24:15,172 --> 00:24:17,507 AND WE'RE SUPPORTING THE 491 00:24:17,507 --> 00:24:24,915 EXPANSION OF BRINGING ENGINEERS 492 00:24:24,915 --> 00:24:26,616 IN THE FIELD IN THE 493 00:24:26,616 --> 00:24:27,951 DISSEMINATION OF BIOMEDICAL, 494 00:24:27,951 --> 00:24:29,553 CLINICAL OR HEALTH-RELATED 495 00:24:29,553 --> 00:24:31,321 RESEARCH TO HELP BUILD SOFTWARE 496 00:24:31,321 --> 00:24:33,423 TOOLS AND ALGORITHMS THAT WILL 497 00:24:33,423 --> 00:24:35,525 HELP US MOVE THE DOT FIELD 498 00:24:35,525 --> 00:24:38,962 FORWARD. 499 00:24:38,962 --> 00:24:39,763 THERE'S ALSO THE STRONG 500 00:24:39,763 --> 00:24:40,530 OPPORTUNITY. 501 00:24:40,530 --> 00:24:42,799 THIS IS FOCUSSED ON CAPACITY 502 00:24:42,799 --> 00:24:46,369 BUILDING AND IS CALLED 503 00:24:46,369 --> 00:24:46,870 STRENGTHENING RESEARCH 504 00:24:46,870 --> 00:24:48,538 OPPORTUNITIES FOR NIH GRANTS. 505 00:24:48,538 --> 00:24:50,440 THIS SUPPORT GOES TO RESEARCH 506 00:24:50,440 --> 00:24:52,776 LIMITED INSTITUTIONS. 507 00:24:52,776 --> 00:24:57,948 AGAIN TO ENHANCE CAPACITY FOR 508 00:24:57,948 --> 00:24:59,549 INDIVIDUALS WHO ARE ALREADY 509 00:24:59,549 --> 00:25:02,953 DOING RESEARCH AND ARE TRAINING 510 00:25:02,953 --> 00:25:05,522 INDIVIDUALS FROM DIVERSE 511 00:25:05,522 --> 00:25:06,323 BACKGROUNDS. 512 00:25:06,323 --> 00:25:09,126 APPLICATIONS ARE DUE NEXT WEEK 513 00:25:09,126 --> 00:25:12,496 FOR THIS YEAR AND THEN DUE 514 00:25:12,496 --> 00:25:14,498 SEPTEMBER 18 FOR 2025 AS WELL. 515 00:25:14,498 --> 00:25:15,565 LOOK AT THE QR CODE IF THERE'S 516 00:25:15,565 --> 00:25:21,972 ANY INTEREST IN THIS. 517 00:25:21,972 --> 00:25:23,907 IN TERMS OF GLOBAL TRAINING 518 00:25:23,907 --> 00:25:24,975 RESOURCES THERE'S MUCH GOING ON. 519 00:25:24,975 --> 00:25:28,078 I DO ENCOURAGE YOU TO LOOK AT 520 00:25:28,078 --> 00:25:31,314 THE TOP QR CODE FOR AN OVERVIEW 521 00:25:31,314 --> 00:25:32,382 OF EXTRAMURAL TRAINING AND 522 00:25:32,382 --> 00:25:34,518 RESEARCH DEVELOPMENT FUNDING 523 00:25:34,518 --> 00:25:35,519 OPPORTUNITIES AND THERE'S A 524 00:25:35,519 --> 00:25:38,088 SLIDE SET THERE. 525 00:25:38,088 --> 00:25:44,161 AND ON THE BOTTOM HERE ARE 526 00:25:44,161 --> 00:25:47,197 RECORDINGS FROM EXTRAMURAL 527 00:25:47,197 --> 00:25:48,632 TRAINING AND CAREER DEVELOPMENT 528 00:25:48,632 --> 00:25:49,065 SESSIONS. 529 00:25:49,065 --> 00:25:51,468 SO PLEASE TAKE A LOOK AT THESE 530 00:25:51,468 --> 00:25:53,537 TWO RESOURCES AS THEY COULD BE 531 00:25:53,537 --> 00:25:59,509 HELPFUL. 532 00:25:59,509 --> 00:26:05,515 NIDCR CONTINUES TO PARTICIPATE 533 00:26:05,515 --> 00:26:15,225 IN THE KIRSCHTEIN RESEARCH AWARD 534 00:26:15,225 --> 00:26:23,533 FOR THOSE WHO HAVE POSTDOCTORAL 535 00:26:23,533 --> 00:26:26,069 TRAINING PROGRAMS. 536 00:26:26,069 --> 00:26:26,703 CONTACT RACIAL SCHUR IF THERE'S 537 00:26:26,703 --> 00:26:27,137 INTEREST IN THAT. 538 00:26:27,137 --> 00:26:29,105 THERE'S THE MENTOR CAREER 539 00:26:29,105 --> 00:26:30,473 DEVELOPMENT AWARD TO PROMOTE 540 00:26:30,473 --> 00:26:31,875 BROAD PARTICIPATION IN RESEARCH. 541 00:26:31,875 --> 00:26:35,512 THIS IS FOR POSTDOCTORAL EARLY 542 00:26:35,512 --> 00:26:37,047 CAREER RESEARCHERS. 543 00:26:37,047 --> 00:26:39,649 THIS WILL OPEN NEXT JANUARY. 544 00:26:39,649 --> 00:26:43,887 IF YOU HAVE AN INTEREST IN THAT 545 00:26:43,887 --> 00:26:49,960 REACH OUT TO SHOBA. 546 00:26:49,960 --> 00:26:51,361 THIS ALSO SUMMER RESEARCH 547 00:26:51,361 --> 00:26:51,895 EXPERIENCE. 548 00:26:51,895 --> 00:26:53,396 PROGRAM TO HELP BUILD TO THE 549 00:26:53,396 --> 00:26:55,732 PATHWAY WITH EDUCATIONAL 550 00:26:55,732 --> 00:26:56,566 ACTIVITIES DURING THE SUMMER 551 00:26:56,566 --> 00:26:59,369 INCLUDING HIGH SCHOOLERS, 552 00:26:59,369 --> 00:27:02,505 UNDERGRADS OR EVEN HIGH SCHOOL 553 00:27:02,505 --> 00:27:02,772 TEACHERS. 554 00:27:02,772 --> 00:27:05,108 THIS OPENS NEXT FEBRUARY IN 555 00:27:05,108 --> 00:27:05,342 2025. 556 00:27:05,342 --> 00:27:07,877 FEEL FREE TO REACH OUT TO RACHEL 557 00:27:07,877 --> 00:27:10,947 FOR THAT. 558 00:27:10,947 --> 00:27:11,881 AND THERE ARE RESOURCE 559 00:27:11,881 --> 00:27:13,383 SUPPLEMENTS THAT WILL PROMOTE 560 00:27:13,383 --> 00:27:15,885 PEOPLE COMING BACK AND 561 00:27:15,885 --> 00:27:17,153 RE-INTEGRATING IN HEALTH RELATED 562 00:27:17,153 --> 00:27:18,555 RESEARCH CAREERS. 563 00:27:18,555 --> 00:27:20,323 SO THERE'S A RESEARCH 564 00:27:20,323 --> 00:27:23,159 SUPPLEMENTS PROGRAM, A 565 00:27:23,159 --> 00:27:24,494 RE-INTEGRATION PROGRAM AND A 566 00:27:24,494 --> 00:27:28,098 RE-TRAINING AND RETOOLING 567 00:27:28,098 --> 00:27:28,732 PROGRAM. 568 00:27:28,732 --> 00:27:29,432 SO THESE ARE WONDERFUL 569 00:27:29,432 --> 00:27:31,901 OPPORTUNITIES FOR PEOPLE TO COME 570 00:27:31,901 --> 00:27:34,904 BACK AND RE-ESTABLISH THEMSELVES 571 00:27:34,904 --> 00:27:37,874 IN SCIENCE AND PLEASE FEEL FREE 572 00:27:37,874 --> 00:27:39,876 TO CONTACT DR. SHOBA FOR THIS 573 00:27:39,876 --> 00:27:43,580 OPPORTUNITY. 574 00:27:43,580 --> 00:27:44,648 FINALLY, WE HAVE THE SCIENCE 575 00:27:44,648 --> 00:27:47,350 EDUCATION AND PARTNERSHIP AWARD 576 00:27:47,350 --> 00:27:49,486 WHICH WE ARE PROUD TO BE 577 00:27:49,486 --> 00:27:51,388 INVOLVED WITH THIS. 578 00:27:51,388 --> 00:27:53,556 THIS REALLY WORKS TO HELP US 579 00:27:53,556 --> 00:27:58,128 ENHANCE OUR PATHWAY TO INCREASE 580 00:27:58,128 --> 00:28:01,564 NUMBERS OF URBAN, RURAL AND 581 00:28:01,564 --> 00:28:02,432 MINORITY STUDENTS TO CONSIDER 582 00:28:02,432 --> 00:28:05,535 RESEARCH AND MEDICAL AND DENTAL 583 00:28:05,535 --> 00:28:07,904 RESEARCH CAREERS. 584 00:28:07,904 --> 00:28:12,509 THIS IS ALSO USED TO HELP WITH 585 00:28:12,509 --> 00:28:13,276 PUBLIC HEALTH LITERACY AND 586 00:28:13,276 --> 00:28:15,445 APPLICATIONS ARE DUE IN JUNE OF 587 00:28:15,445 --> 00:28:16,146 NEXT YEAR. 588 00:28:16,146 --> 00:28:20,283 PLEASE CONSIDER SEPA IF YOU CAN. 589 00:28:20,283 --> 00:28:21,685 UPCOMING ARE SOME EVENTS THAT 590 00:28:21,685 --> 00:28:24,788 I'D LIKE TO SHARE WITH YOU. 591 00:28:24,788 --> 00:28:27,290 THE FIRST IS THE NIH DIVERSITY 592 00:28:27,290 --> 00:28:31,127 SUPPLEMENT DIVERSITY WORKSHOP. 593 00:28:31,127 --> 00:28:34,097 IS THIS IS GOING TO OCCUR IN TWO 594 00:28:34,097 --> 00:28:36,499 WEEKS, SEPTEMBER 24 TO 25. 595 00:28:36,499 --> 00:28:38,134 AND NIDCR IS PARTICIPATING AND 596 00:28:38,134 --> 00:28:39,903 IT WOULD BE WONDERFUL TO HAVE 597 00:28:39,903 --> 00:28:43,907 YOU JOIN US IF YOU CAN. 598 00:28:43,907 --> 00:28:46,843 PLEASE REGISTER FOR THE WORKSHOP 599 00:28:46,843 --> 00:28:47,143 AND JOIN US. 600 00:28:47,143 --> 00:28:52,115 THE OTHER THING THAT'S COMING UP 601 00:28:52,115 --> 00:28:55,418 IS NIDCR'S CO-SPONSORING AN 602 00:28:55,418 --> 00:28:59,122 IMPORTANT PUBLIC WORKSHOP. 603 00:28:59,122 --> 00:29:03,460 IT'S A WORKSHOP THROUGH THE 604 00:29:03,460 --> 00:29:04,327 NATIONAL ACADEMIES TO REALLY 605 00:29:04,327 --> 00:29:08,598 BUILD AN ACTION ORIENTED PLAN 606 00:29:08,598 --> 00:29:09,499 TOWARD ADVANCING ORAL HEALTH 607 00:29:09,499 --> 00:29:14,804 ACROSS THE LIFE SPAN. 608 00:29:14,804 --> 00:29:16,673 TO BUILD NATIONAL ORAL HEALTH 609 00:29:16,673 --> 00:29:16,873 GOALS. 610 00:29:16,873 --> 00:29:19,142 TO BUILD SUSTAINABLE SOLUTIONS 611 00:29:19,142 --> 00:29:21,911 TOWARDS IMPROVING ACCESS TO ORAL 612 00:29:21,911 --> 00:29:23,513 HEALTH AND SERVICES. 613 00:29:23,513 --> 00:29:24,381 TOWARDS BUILDING INTEGRATION 614 00:29:24,381 --> 00:29:27,884 MODELS AS WE HAVE IN OUR 615 00:29:27,884 --> 00:29:29,519 STRATEGIC PLAN. 616 00:29:29,519 --> 00:29:33,456 TOWARDS EMPOWERING CONSUMERS SO 617 00:29:33,456 --> 00:29:35,525 THEY CAN MAKE CHOICES RELATED TO 618 00:29:35,525 --> 00:29:45,135 THEIR ORAL HEALTH. 619 00:29:45,135 --> 00:29:48,772 AND TOWARDS PUBLIC EDUCATION 620 00:29:48,772 --> 00:29:51,875 CAMPAIGNS AND THE RESEARCH AND 621 00:29:51,875 --> 00:29:52,542 INNOVATIONS MOVING US TOWARDS 622 00:29:52,542 --> 00:29:53,977 ORAL HEALTH FOR ALL OVER THE 623 00:29:53,977 --> 00:29:54,844 NEXT FIVE TO 10 YEARS. 624 00:29:54,844 --> 00:29:57,547 THAT'S COMING THIS NOVEMBER. 625 00:29:57,547 --> 00:30:01,117 WE'RE EXCITED TO BE SPONSORING 626 00:30:01,117 --> 00:30:03,920 THAT AND I HOPE YOU ALL WILL 627 00:30:03,920 --> 00:30:09,092 TAKE PART IN THAT. 628 00:30:09,092 --> 00:30:11,494 I'M JUST GOING TO SHARE WITH YOU 629 00:30:11,494 --> 00:30:13,963 SOME SELECTED SCIENCE ADVANCES 630 00:30:13,963 --> 00:30:16,966 BECAUSE OUR SCIENCE REALLY IS 631 00:30:16,966 --> 00:30:20,069 MOVING FORWARD. 632 00:30:20,069 --> 00:30:22,739 HERE WITH REGARD TO BONE GROWTH. 633 00:30:22,739 --> 00:30:25,208 THERE'S A NEW DRAMATICALLY 634 00:30:25,208 --> 00:30:30,747 ENGINEERED MOUSE MODEL THAT HAS 635 00:30:30,747 --> 00:30:33,283 DEMONSTRATED THE ABILITY NOW 636 00:30:33,283 --> 00:30:35,652 TRACE OF CHONDROCYTES AND SEE 637 00:30:35,652 --> 00:30:43,026 NOVEL MECHANISMS THAT FACILITATE 638 00:30:43,026 --> 00:30:46,229 OUR UNDERSTANDING WHAT HAPPENS 639 00:30:46,229 --> 00:30:47,530 IN THE RESTING ZONE OF THE BONE 640 00:30:47,530 --> 00:30:49,332 GROWTH PLATE. 641 00:30:49,332 --> 00:30:50,767 WITH REGARD TO CANCER TREATMENT, 642 00:30:50,767 --> 00:30:53,236 THERE'S BEEN REAL CHALLENGES IN 643 00:30:53,236 --> 00:30:59,409 UTILIZING PD1 THERAPEUTICS BUT 644 00:30:59,409 --> 00:31:02,212 NOW THERE'S BEEN RESEARCH THAT 645 00:31:02,212 --> 00:31:05,548 STAR GETS DENDRITIC CELLS THAT 646 00:31:05,548 --> 00:31:07,183 HELPS CIRCUMVENT RESISTANCE IN 647 00:31:07,183 --> 00:31:10,720 HEAD AND NECK CANCER. 648 00:31:10,720 --> 00:31:13,523 AND WITH REGARD TO CRANIOFACIAL 649 00:31:13,523 --> 00:31:19,896 DEVELOPMENT, THERE'S WORK 650 00:31:19,896 --> 00:31:30,373 ONGOING TO EXPAND CALVARIAL 651 00:31:31,407 --> 00:31:31,674 OSTEOBLASTS. 652 00:31:31,674 --> 00:31:32,609 AND THIS RESEARCH IS HELPING 653 00:31:32,609 --> 00:31:41,351 MOVE THINGS FORWARD. 654 00:31:41,351 --> 00:31:43,152 WE'LL END THERE WITH UPDATES AND 655 00:31:43,152 --> 00:31:45,455 WILL SHARE SCIENCE EXPERIMENTS 656 00:31:45,455 --> 00:31:49,659 IN THE CONTEXT OF SECTION 2. 657 00:31:49,659 --> 00:31:52,896 AGAIN, HERE WE'RE GOING TO FOCUS 658 00:31:52,896 --> 00:31:55,732 ON HOW WE MOVE TOWARDS HEALTH 659 00:31:55,732 --> 00:31:57,667 AND ORAL HEALTH FOR ALL. 660 00:31:57,667 --> 00:32:05,308 AND SHARE HOW NIDCR IS ALIGNED 661 00:32:05,308 --> 00:32:07,911 WITH THE DATA ON PRIMARY CARE 662 00:32:07,911 --> 00:32:10,313 AND OUR NIH DIRECTOR WAS HERE 663 00:32:10,313 --> 00:32:11,881 LAST COUNCIL TO SHARE WITH HER 664 00:32:11,881 --> 00:32:13,049 WHAT THE VISION WAS. 665 00:32:13,049 --> 00:32:16,286 AND WHAT SHE SHARED WAS THERE 666 00:32:16,286 --> 00:32:18,888 WERE TWO CRITICAL PRIORITIES. 667 00:32:18,888 --> 00:32:21,324 THE FIRST IS TO EXPAND NIH'S 668 00:32:21,324 --> 00:32:24,494 CAPABILITIES FOR DATA SHARING 669 00:32:24,494 --> 00:32:27,564 AND DATA USE FOR EVERYONE BY THE 670 00:32:27,564 --> 00:32:29,532 BROADEST POSSIBLE RESEARCH 671 00:32:29,532 --> 00:32:29,832 COMMUNITY. 672 00:32:29,832 --> 00:32:33,369 AND THE SECOND IS TO EXTEND OUR 673 00:32:33,369 --> 00:32:35,104 CLINICAL RESEARCH CAPABILITIES 674 00:32:35,104 --> 00:32:37,840 TO ADDRESS GAPS IN EVIDENCE TO 675 00:32:37,840 --> 00:32:39,676 GUIDE CLINICAL CARE AND SERVE 676 00:32:39,676 --> 00:32:41,578 THE NEEDS OF EVERY COMMUNITY. 677 00:32:41,578 --> 00:32:43,713 MAKING SURE THE RESEARCH IS 678 00:32:43,713 --> 00:32:44,314 GETTING TO EVERYONE WHO NEEDS 679 00:32:44,314 --> 00:32:50,453 IT. 680 00:32:50,453 --> 00:32:53,923 AND WHAT WE KNOW IS IT WILL TAKE 681 00:32:53,923 --> 00:32:56,092 DATA PLUS WHOLE PERSON HEALTH 682 00:32:56,092 --> 00:32:59,395 APPROACH AND PRIMARY CARE 683 00:32:59,395 --> 00:33:01,297 INTEGRATION WHERE WE RECOGNIZE 684 00:33:01,297 --> 00:33:03,199 ORAL DISEASE AS A MODIFIABLE 685 00:33:03,199 --> 00:33:05,768 RISK FACTOR. 686 00:33:05,768 --> 00:33:07,103 AND THESE TWO THINGS TOGETHER 687 00:33:07,103 --> 00:33:09,539 WILL HELP GET US TO ORAL HEALTH 688 00:33:09,539 --> 00:33:11,874 AND IMPROVED HEALTH FOR ALL. 689 00:33:11,874 --> 00:33:12,875 LET'S START WITH DATA SHARING 690 00:33:12,875 --> 00:33:22,118 AND DATA USE. 691 00:33:22,118 --> 00:33:25,488 SO NIDCR IS CLOSELY ALIGNED WITH 692 00:33:25,488 --> 00:33:27,490 THE NIH DATA MANAGEMENT AND 693 00:33:27,490 --> 00:33:32,128 SHARING POLICIES TO MAKE SURE 694 00:33:32,128 --> 00:33:40,803 THAT ALL THE DATA COMING FROM 695 00:33:40,803 --> 00:33:41,504 DIFFERENT DATA IS ACCESSIBLE TO 696 00:33:41,504 --> 00:33:51,681 EVERYONE. 697 00:33:52,248 --> 00:33:53,516 THEY ESTABLISH RELATIONSHIPS 698 00:33:53,516 --> 00:33:59,522 THROUGH REPOSITORIES AND THE 699 00:33:59,522 --> 00:34:01,124 ORAL MOOISH BIOMEDICAL DATABASE 700 00:34:01,124 --> 00:34:02,025 AND SALIVARY PROTEOME. 701 00:34:02,025 --> 00:34:04,927 IN FACT WE ASSEMBLED A DATA 702 00:34:04,927 --> 00:34:07,030 SCIENCE STRATEGY WORKING GROUP 703 00:34:07,030 --> 00:34:08,164 THROUGH OUR COUNCIL WITH A 704 00:34:08,164 --> 00:34:11,534 SUBGROUP OF OUR COUNCIL WHO 705 00:34:11,534 --> 00:34:13,002 DEVELOPED AND SHARED 706 00:34:13,002 --> 00:34:15,772 RECOMMENDATIONS FOR US THAT I'LL 707 00:34:15,772 --> 00:34:23,513 GO OVER IN A MOMENT. 708 00:34:23,513 --> 00:34:29,052 BOTH ON THE INTRAMURAL AND 709 00:34:29,052 --> 00:34:32,422 EXTRAMURAL SIDE THE SUPPORT ON 710 00:34:32,422 --> 00:34:35,525 THE NIH CAMPUS, EVERY PRINCIPLE 711 00:34:35,525 --> 00:34:39,896 INVESTIGATOR HAS INTEGRATED DETE 712 00:34:39,896 --> 00:34:40,596 SHARING INTO THEIR PLANS. 713 00:34:40,596 --> 00:34:43,366 WE ARE WORKING ON OUR PUBLIC 714 00:34:43,366 --> 00:34:47,336 DATA INFRASTRUCTURE TO BETTER 715 00:34:47,336 --> 00:34:49,639 DEMOCRATIZE LARGE DATA SETS AND 716 00:34:49,639 --> 00:34:51,874 NIDCR'S CAPITALIZING ON EXISTING 717 00:34:51,874 --> 00:34:53,810 NIH RESOURCES TO STORE AND 718 00:34:53,810 --> 00:34:55,912 MANAGE DATA IN ORDER TO 719 00:34:55,912 --> 00:34:59,549 FACILITATE ACCESS AND SHARING 720 00:34:59,549 --> 00:35:01,317 FOR EVERYONE. 721 00:35:01,317 --> 00:35:02,485 ON THE EXTRAMURAL SIDE ACROSS 722 00:35:02,485 --> 00:35:05,688 THE U.S. AND AROUND THE WORLD, 723 00:35:05,688 --> 00:35:07,890 WE'RE MAKING EXISTING DIVERSE 724 00:35:07,890 --> 00:35:11,527 AND INCLUSIVE ORAL HEALTH 725 00:35:11,527 --> 00:35:12,395 DATABASES ACCESSIBLE. 726 00:35:12,395 --> 00:35:15,965 WE'RE EXPANDING AND DEVELOPING 727 00:35:15,965 --> 00:35:19,235 COMMON DATA ELEMENTS ACROSS 728 00:35:19,235 --> 00:35:20,136 RESEARCH INITIATIVES AND EFFORTS 729 00:35:20,136 --> 00:35:24,574 SO WE'LL BE ABLE TO HARMONIZE 730 00:35:24,574 --> 00:35:28,010 THE DATA AND BE ABLE TO SHARE 731 00:35:28,010 --> 00:35:28,311 AND USE IT. 732 00:35:28,311 --> 00:35:30,146 WE ARE SUPPORTING FUNDING 733 00:35:30,146 --> 00:35:31,881 OPPORTUNITIES FOR DATA SCIENCE 734 00:35:31,881 --> 00:35:34,450 AND SUPPORTING RESEARCH TRAINING 735 00:35:34,450 --> 00:35:35,785 AND CAREER DEVELOPMENT THAT'S 736 00:35:35,785 --> 00:35:37,286 DATA SCIENCE RELATED. 737 00:35:37,286 --> 00:35:38,054 SO HOW ARE WE DOING IT THROUGH 738 00:35:38,054 --> 00:35:40,590 TRAINING? 739 00:35:40,590 --> 00:35:42,592 THERE ARE SEVERAL INITIATIVES 740 00:35:42,592 --> 00:35:45,361 ONGOING INCLUDING THE NOSI 741 00:35:45,361 --> 00:35:48,331 FOCUSSED ON APPLICATIONS OF DATA 742 00:35:48,331 --> 00:35:49,398 SCIENCE IN DENTAL ORAL AND 743 00:35:49,398 --> 00:35:53,536 CRANIOFACIAL RESEARCH. 744 00:35:53,536 --> 00:35:56,472 AND THERE'S A K25 MENTORED AWARD 745 00:35:56,472 --> 00:35:58,040 FOCUSSED ON QUANTITATIVE 746 00:35:58,040 --> 00:35:59,575 RESEARCH AND INCLUDES DATA 747 00:35:59,575 --> 00:36:01,410 SCIENCE AND THERE ARE 748 00:36:01,410 --> 00:36:02,078 INSTITUTIONAL PROGRAM TRAINING 749 00:36:02,078 --> 00:36:02,678 GRANTS THAT CAN FOCUS ON DATA 750 00:36:02,678 --> 00:36:04,247 SCIENCE. 751 00:36:04,247 --> 00:36:07,884 AND IN FACT RIGHT NOW WE'RE 752 00:36:07,884 --> 00:36:11,554 SUPPORTING ABOUT 40 TRAINING 753 00:36:11,554 --> 00:36:14,991 AWARDS FOCUSSED ON ARTIFICIAL 754 00:36:14,991 --> 00:36:16,859 INTELLIGENCE AND MACHINE 755 00:36:16,859 --> 00:36:21,097 LEARNING AND BIOINFORMATICS. 756 00:36:21,097 --> 00:36:23,065 REGARDING OUR WORKING GROUP THE 757 00:36:23,065 --> 00:36:28,838 REPORT HAS BEEN COMPLETED AND WE 758 00:36:28,838 --> 00:36:29,839 ENCOURAGE YOU TO TAKE A LOOK AT 759 00:36:29,839 --> 00:36:33,643 IT ON THE WEBSITE BUT HAD FIVE 760 00:36:33,643 --> 00:36:33,976 MAJOR ELEMENT. 761 00:36:33,976 --> 00:36:43,386 CREATING A DATA INFRASTRUCTURE 762 00:36:43,386 --> 00:36:49,926 TAILORED TO DENTAL ORAL 763 00:36:49,926 --> 00:36:50,660 CRANIOFACIAL RESEARCH AND 764 00:36:50,660 --> 00:36:51,894 VISUALIZATION TOOLS FOR THE 765 00:36:51,894 --> 00:36:53,296 FIELD AND ENHANCING THE DATA 766 00:36:53,296 --> 00:36:53,963 SCIENCE WORKFORCE DEVELOPMENT 767 00:36:53,963 --> 00:36:56,899 AND MAKING SURE THE TRAINING IS 768 00:36:56,899 --> 00:37:00,136 INCLUSIVE AND PROMOTING DATA 769 00:37:00,136 --> 00:37:01,804 STEWARDSHIP AS WELL AS 770 00:37:01,804 --> 00:37:03,005 SUSTAINABLE DATA PRACTICES. 771 00:37:03,005 --> 00:37:05,541 WE'RE MOVING IN THAT DIRECTION. 772 00:37:05,541 --> 00:37:11,347 WE PARTNER WITH RESOURCES AND 773 00:37:11,347 --> 00:37:12,715 COLLABORATORS ACROSS NIH AND 774 00:37:12,715 --> 00:37:13,583 ELSE WHERE TO PROMOTE DATA 775 00:37:13,583 --> 00:37:14,584 SHARING AND USE. 776 00:37:14,584 --> 00:37:18,988 YOU CAN SEE A PLETHORA OUTLINED 777 00:37:18,988 --> 00:37:21,457 HERE ACROSS MULTIPLE CONSORTIA 778 00:37:21,457 --> 00:37:24,293 AND WE'RE BUILDING A DATA HUB. 779 00:37:24,293 --> 00:37:26,195 IT WILL LAUNCH IN THE WINTER OF 780 00:37:26,195 --> 00:37:26,596 2024. 781 00:37:26,596 --> 00:37:29,932 SO WITHIN THE NEXT FEW MONTHS. 782 00:37:29,932 --> 00:37:33,669 THIS DDS HUB, PUN INTENDED, HERE 783 00:37:33,669 --> 00:37:34,604 STANDS FOR DATA DRIVEN SCIENCE. 784 00:37:34,604 --> 00:37:37,740 THIS IS OUR RESPONSE TO THE NEED 785 00:37:37,740 --> 00:37:43,012 TO HAVE A ONE-STOP-SHOP, A 786 00:37:43,012 --> 00:37:44,513 CENTRALIZED PLACE TO CONNECT 787 00:37:44,513 --> 00:37:47,550 DENTAL AND CRANIORESEARCHERS 788 00:37:47,550 --> 00:37:50,019 THAT EXPAND THE SPECTRUM FROM 789 00:37:50,019 --> 00:37:51,687 THE MOLECULAR LEVEL OUT TO THE 790 00:37:51,687 --> 00:37:52,755 POPULATION LEVEL AND HAVE ALL 791 00:37:52,755 --> 00:37:57,293 THOSE RESOURCES IN ONE PLACE. 792 00:37:57,293 --> 00:38:00,529 HIGHLIGHTED WILL BE FAIR DATA S 793 00:38:00,529 --> 00:38:02,632 SO THERE WILL BE ACCESS TO 794 00:38:02,632 --> 00:38:05,234 SUMMARY INFORMATION ON THE 795 00:38:05,234 --> 00:38:07,236 DIVERSITY AND DEMOGRAPHIC BREAK 796 00:38:07,236 --> 00:38:08,638 DOWN OF THE DATA SETS. 797 00:38:08,638 --> 00:38:10,439 THE HUB WILL FEATURE 798 00:38:10,439 --> 00:38:12,608 COMPUTATIONAL AND ANALYTIC 799 00:38:12,608 --> 00:38:14,277 RESOURCES FOR DATA SCIENCE 800 00:38:14,277 --> 00:38:14,543 RESEARCH. 801 00:38:14,543 --> 00:38:17,546 AND THIS WILL INCLUDE WORK 802 00:38:17,546 --> 00:38:19,215 SPACES, NOTEBOOKS, CODE 803 00:38:19,215 --> 00:38:21,284 REPOSITORIES AND TRAINING 804 00:38:21,284 --> 00:38:21,517 MODULES. 805 00:38:21,517 --> 00:38:22,785 FINALLY, THERE WILL BE GUIDANCE 806 00:38:22,785 --> 00:38:27,690 ON DATA REUSE AND SHARING THAT 807 00:38:27,690 --> 00:38:28,791 INCLUDES DATA MANAGEMENT AND 808 00:38:28,791 --> 00:38:34,363 SHARING GUIDELINES AS WELL AS 809 00:38:34,363 --> 00:38:35,031 TUTORIALS. 810 00:38:35,031 --> 00:38:38,834 HERE'S A GRAPHIC THAT CAPTURES 811 00:38:38,834 --> 00:38:41,203 THE SENTIMENT OF WHAT THIS DDS 812 00:38:41,203 --> 00:38:42,305 HUB WILL DO. 813 00:38:42,305 --> 00:38:43,873 THIS WILL BE A COMMUNITY-ENGAGED 814 00:38:43,873 --> 00:38:47,543 AN DRIVEN HUB THAT WILL FOSTER 815 00:38:47,543 --> 00:38:49,245 COLLABORATIONS AND PROMOTE 816 00:38:49,245 --> 00:38:51,814 DISSEMINATION IN TERMS OF THE 817 00:38:51,814 --> 00:38:52,882 ANALYTIC RESOURCES. 818 00:38:52,882 --> 00:38:54,884 THEY ARE BEGINNER FRIENDLY. 819 00:38:54,884 --> 00:38:55,885 THERE WILL BE INFORMING ON 820 00:38:55,885 --> 00:38:59,021 GRANTS AND FUNDING THERE. 821 00:38:59,021 --> 00:39:01,624 OPPORTUNITIES TO GENERATE FAIR 822 00:39:01,624 --> 00:39:03,759 DATA USING STANDARDIZED 823 00:39:03,759 --> 00:39:06,629 TERMINOLOGIES AND COMMON DATA 824 00:39:06,629 --> 00:39:06,896 ELEMENTS. 825 00:39:06,896 --> 00:39:09,999 THERE'LL BE DATA CURATION AND 826 00:39:09,999 --> 00:39:11,867 REUSE THERE AT POPULATION AND 827 00:39:11,867 --> 00:39:13,402 INDIVIDUAL LEVEL CLINICAL AND 828 00:39:13,402 --> 00:39:15,571 BASIC SCIENCE DATA FOR RESEARCH. 829 00:39:15,571 --> 00:39:18,641 AND FINALLY, WITH REGARD TO DATA 830 00:39:18,641 --> 00:39:19,842 MANAGEMENT AND SHARING THERE'LL 831 00:39:19,842 --> 00:39:21,777 BE GUIDELINES AND TUTORIALS TO 832 00:39:21,777 --> 00:39:24,814 MAKE SURE THAT WE'RE PROMOTING 833 00:39:24,814 --> 00:39:27,416 TRANSPARENCY, REPRODUCIBILITY 834 00:39:27,416 --> 00:39:28,451 AND DATA REUSE AS WELL. 835 00:39:28,451 --> 00:39:30,886 ALL THESE THINGS WILL HELP WITH 836 00:39:30,886 --> 00:39:33,556 RIGOR IN OUR SCIENCE. 837 00:39:33,556 --> 00:39:37,560 SO WE ARE WORKING HARD TO FORGE 838 00:39:37,560 --> 00:39:40,696 CONNECTIONS ACROSS DATA SOURCES. 839 00:39:40,696 --> 00:39:42,298 WE'RE COLLABORATING WITH MANY 840 00:39:42,298 --> 00:39:44,700 PARTNERS AND OTHER FUNDERS. 841 00:39:44,700 --> 00:39:49,739 OF COURSE WE HAVE THE ORAL 842 00:39:49,739 --> 00:39:52,842 MICROBIOME PROTEOME DATABASES. 843 00:39:52,842 --> 00:39:55,878 WE HAVE FACE BASE. 844 00:39:55,878 --> 00:39:58,214 WITH REGARD TO COLLABORATION 845 00:39:58,214 --> 00:40:01,183 WITH NCI WE HAVE THE EARLY 846 00:40:01,183 --> 00:40:05,287 DETECTION RESEARCH INITIATIVE I 847 00:40:05,287 --> 00:40:07,523 SPOKE ABOUT EARLIER AS WELL AS 848 00:40:07,523 --> 00:40:09,992 THE OVER ALL NCI SUPPORTED 849 00:40:09,992 --> 00:40:12,261 EARLIER RESEARCH DETECTION 850 00:40:12,261 --> 00:40:12,495 NETWORK. 851 00:40:12,495 --> 00:40:14,730 THERE ARE NCI DATA COMMONS THAT 852 00:40:14,730 --> 00:40:16,899 INCLUDES IMAGING THAT WILL BE 853 00:40:16,899 --> 00:40:19,201 AVAILABLE ON THE HUB AND ALSO 854 00:40:19,201 --> 00:40:23,873 THE NCI BIO SPECIMEN RESOURCE. 855 00:40:23,873 --> 00:40:27,009 WE ARE WORKING TO INCLUDE THE 856 00:40:27,009 --> 00:40:30,079 AUTO IMMUNE RESEARCH COMMON DATA 857 00:40:30,079 --> 00:40:34,216 ELEMENTS THROUGH ORWH AND WITHIN 858 00:40:34,216 --> 00:40:36,485 SEVERAL MONTHS THERE WILL BE A 859 00:40:36,485 --> 00:40:38,521 THINK TANK ON COMMON DATA 860 00:40:38,521 --> 00:40:39,889 ELEMENTS FOR DENTAL ORAL AND 861 00:40:39,889 --> 00:40:41,557 CRANIOFACIAL RESEARCH. 862 00:40:41,557 --> 00:40:43,626 AND WE LOOK FORWARD TO YOUR 863 00:40:43,626 --> 00:40:44,527 JOINING US AS WE MOVE FORWARD IN 864 00:40:44,527 --> 00:40:46,629 THAT SPACE. 865 00:40:46,629 --> 00:40:48,764 WE'RE WORKING WITH ALL OF US AND 866 00:40:48,764 --> 00:40:50,933 YOU'LL HEAR MORE ABOUT THIS THIS 867 00:40:50,933 --> 00:40:52,902 AFTERNOON AND WE HAVE CURATED 868 00:40:52,902 --> 00:40:55,037 DATA FROM OUR NATIONAL DENTAL 869 00:40:55,037 --> 00:40:56,305 PRACTICE-BASED RESEARCH NETWORK. 870 00:40:56,305 --> 00:41:00,309 AND WE HAVE ALSO MULTIPLE SITES 871 00:41:00,309 --> 00:41:03,045 THAT HAVE ALREADY SENT OR AGREED 872 00:41:03,045 --> 00:41:06,182 TO SEND SUMMARY AND AGGREGATE 873 00:41:06,182 --> 00:41:10,453 LEVEL LEVEL AND THE BIG MOUTH 874 00:41:10,453 --> 00:41:12,354 REPOSITORY THE WISCONSIN 875 00:41:12,354 --> 00:41:13,055 COLLABORATIVE FOR HEALTH CARE 876 00:41:13,055 --> 00:41:16,459 EQUITY THE AMERICAN DENTAL 877 00:41:16,459 --> 00:41:19,361 ASSOCIATION, OPERATION SMILE AND 878 00:41:19,361 --> 00:41:20,629 WITHIN THE NEXT UPDATE WE'RE 879 00:41:20,629 --> 00:41:22,398 EXPECTED TO HAVE THE ASSOCIATION 880 00:41:22,398 --> 00:41:27,870 OF STATES AND TERRITORIES ORA 881 00:41:27,870 --> 00:41:30,840 STDD CURATED SURVEYS AND WE'RE 882 00:41:30,840 --> 00:41:31,440 MOVING FORWARD AND THERE ARE 883 00:41:31,440 --> 00:41:32,875 OTHERS THAT WE'RE TRYING TO 884 00:41:32,875 --> 00:41:35,144 BRING IN THAT WE'RE WORKING TO 885 00:41:35,144 --> 00:41:37,780 BRING INTO THE FOLD TO HAVE 886 00:41:37,780 --> 00:41:39,682 LARGE DATA SETS TO HELP US 887 00:41:39,682 --> 00:41:45,488 ANSWER BIG PICTURE QUESTIONS. 888 00:41:45,488 --> 00:41:47,389 THAT'S ACROSS OUR FIELD. 889 00:41:47,389 --> 00:41:50,292 WE ARE BUILDING CURATED ANALYTIC 890 00:41:50,292 --> 00:41:51,927 RESOURCES THAT WILL BE HELD AT 891 00:41:51,927 --> 00:41:54,196 THE HUB. 892 00:41:54,196 --> 00:41:57,500 THIS INCLUDES STRIDE, THE NIH 893 00:41:57,500 --> 00:42:03,105 CLOUD, THE NIGMS SANDBOX AND THE 894 00:42:03,105 --> 00:42:06,208 ALL OF US PUBLIC WORK SPACES AND 895 00:42:06,208 --> 00:42:09,778 TERRA WORK SPACES AND SCHARE 896 00:42:09,778 --> 00:42:11,480 I'LL PROVIDE MORE ABOUT IN A 897 00:42:11,480 --> 00:42:12,515 SECOND. 898 00:42:12,515 --> 00:42:15,518 ALL THESE THINGS WILL BE PRESENT 899 00:42:15,518 --> 00:42:19,889 IN THE ONE-STOP-SHOP FOR US AND 900 00:42:19,889 --> 00:42:20,856 OUR COMMUNITY. 901 00:42:20,856 --> 00:42:22,858 WE HAVE AN INITIATIVE ONGOING 902 00:42:22,858 --> 00:42:24,760 FOCUSSED ON UTILIZING COMMUNITY 903 00:42:24,760 --> 00:42:27,429 ENGAGEMENT AND DATA SCIENCE TO 904 00:42:27,429 --> 00:42:29,865 REALLY ACQUIRE THE EVIDENCE WE 905 00:42:29,865 --> 00:42:31,567 NEED TO HELP DIMINISH ORAL 906 00:42:31,567 --> 00:42:33,169 HEALTH DISPARITIES. 907 00:42:33,169 --> 00:42:39,808 AS PART OF THIS BEING LED BY A 908 00:42:39,808 --> 00:42:42,745 PROGRAM OFFICER THE 909 00:42:42,745 --> 00:42:43,779 COLLABORATION WITH THE NIMHD 910 00:42:43,779 --> 00:42:47,049 SCIENCE COLLABORATIVE FOR HEALTH 911 00:42:47,049 --> 00:42:47,816 DISPARITIES AND ARTIFICIAL 912 00:42:47,816 --> 00:42:51,153 INTELLIGENCE BIAS REDUCTION. 913 00:42:51,153 --> 00:42:56,992 SO WHAT THEY'RE WORKING TO DO IS 914 00:42:56,992 --> 00:43:02,598 INCREASE PARTICIPATION OF WOMEN 915 00:43:02,598 --> 00:43:05,534 AND OTHER UNDER REPRESENTED 916 00:43:05,534 --> 00:43:07,169 POPULATIONS IN DATA SCIENCE AND 917 00:43:07,169 --> 00:43:09,238 CLOUD COMPUTING TOOLS AND 918 00:43:09,238 --> 00:43:11,874 ADVANCING A.I. BIASSED 919 00:43:11,874 --> 00:43:12,341 MITIGATION. 920 00:43:12,341 --> 00:43:14,510 THIS CLOUD-BASED PLATFORM WILL 921 00:43:14,510 --> 00:43:16,078 BE AVAILABLE TO OUR COMMUNITY 922 00:43:16,078 --> 00:43:26,355 THROUGH OUR HUB. 923 00:43:29,592 --> 00:43:33,095 THE INITIATIVE TO BUILD 924 00:43:33,095 --> 00:43:34,263 SUSTAINABLE SOFTWARE TOOLS THAT 925 00:43:34,263 --> 00:43:37,766 IS OPEN SCIENCE AND HELP US MOVE 926 00:43:37,766 --> 00:43:47,409 FORWARD WITH DOC DATA ANALYSIS. 927 00:43:47,409 --> 00:43:49,912 HOW ARE WE USING DATA DRIVEN 928 00:43:49,912 --> 00:43:51,213 APPROACHES TO IMPROVE ORAL 929 00:43:51,213 --> 00:43:51,447 HEALTH? 930 00:43:51,447 --> 00:43:53,482 THERE'S ALREADY GREAT SCIENCE IN 931 00:43:53,482 --> 00:43:54,883 THE PIPELINE. 932 00:43:54,883 --> 00:44:01,190 HERE I'LL SHARE A FEW SCIENCE 933 00:44:01,190 --> 00:44:05,060 ADVANCES THAT DEMONSTRATE THIS. 934 00:44:05,060 --> 00:44:09,398 HERE FROM KIM ET AL. WE SEE THE 935 00:44:09,398 --> 00:44:12,534 USE OF OMICS-LEVEL DATA AND 936 00:44:12,534 --> 00:44:15,871 UTILIZATION OF THE TRANSCRIPTOME 937 00:44:15,871 --> 00:44:18,007 TO HELP US UNDERSTAND RARE 938 00:44:18,007 --> 00:44:21,910 IMMUNE CELL SUBSETS THAT OCCUR 939 00:44:21,910 --> 00:44:27,549 IN CHILDREN WITH SJOGREN'S 940 00:44:27,549 --> 00:44:30,085 DISEASE AND THERE'S ANOTHER 941 00:44:30,085 --> 00:44:35,357 INITIATIVE THAT IS SLIDE FREE 942 00:44:35,357 --> 00:44:40,329 HISTOLOGY WITH MACHINE LEARNING 943 00:44:40,329 --> 00:44:48,237 PLATFORMS AND WE HAVE SOMETHING 944 00:44:48,237 --> 00:44:50,406 AND THERE'S A GOOD EXAMPLE OF 945 00:44:50,406 --> 00:44:52,541 HOW WE'RE LEVERAGING DATA TO 946 00:44:52,541 --> 00:44:55,244 HELP US WITH CLINICAL 947 00:44:55,244 --> 00:45:02,184 DIAGNOSTICS AND THIS IS FROM JEN 948 00:45:02,184 --> 00:45:05,888 ET AL AND USING OMICS DATA TO 949 00:45:05,888 --> 00:45:07,523 HELP US UNDERSTAND CHRONIC PAIN. 950 00:45:07,523 --> 00:45:11,160 LOOKING AT TRANSCRIPTOMIC 951 00:45:11,160 --> 00:45:14,730 PROFILES IN TMD PATIENTS. 952 00:45:14,730 --> 00:45:20,803 THIS WORK IS FROM COLLOCA ET AL. 953 00:45:20,803 --> 00:45:22,571 THESE FINDINGS WILL HELP LEAD TO 954 00:45:22,571 --> 00:45:28,143 IDENTIFICATION OF BIOMARKERS FOR 955 00:45:28,143 --> 00:45:30,112 PLACEBO. 956 00:45:30,112 --> 00:45:33,015 SO THERE'S LOTS OF SPACE TO USE 957 00:45:33,015 --> 00:45:35,718 DATA TO HELP US MOVE CLINICAL 958 00:45:35,718 --> 00:45:44,026 CARE FORWARD. 959 00:45:44,026 --> 00:45:47,363 THAT WAS DATA. 960 00:45:47,363 --> 00:45:51,266 NOW WHERE ARE WE WITH PRIMARY 961 00:45:51,266 --> 00:45:53,268 CARE INTEGRATION. 962 00:45:53,268 --> 00:45:59,208 THERE WAS A 2000 SURGEON GENERAL 963 00:45:59,208 --> 00:46:00,008 REPORT AND NEED TO GET TO 964 00:46:00,008 --> 00:46:02,177 COMMUNITIES AND RESEARCH THERE. 965 00:46:02,177 --> 00:46:06,749 WE ARE REALLY WORKING TO FOSTER 966 00:46:06,749 --> 00:46:09,985 CLINICAL RESEARCH COLLABORATIONS 967 00:46:09,985 --> 00:46:11,553 THAT ADVANCE DENTAL ORAL AND 968 00:46:11,553 --> 00:46:15,190 CRANIOFACIAL CLINICAL WORK AND 969 00:46:15,190 --> 00:46:16,091 STRATEGICALLY ADDRESS HEALTH 970 00:46:16,091 --> 00:46:16,425 DISPARITIES. 971 00:46:16,425 --> 00:46:18,794 IN FACT WE HAVE TWO NETWORKS. 972 00:46:18,794 --> 00:46:21,530 ONE, THE 20-YEAR SUPPORT OF THE 973 00:46:21,530 --> 00:46:23,432 DENTAL PRACTICE-BASED RESEARCH 974 00:46:23,432 --> 00:46:27,870 NETWORK OR PBRN AND TO THE NEWLY 975 00:46:27,870 --> 00:46:31,607 LAUNCHED DENTAL SCHOOL-BASED 976 00:46:31,607 --> 00:46:31,874 PBRN. 977 00:46:31,874 --> 00:46:33,642 THESE NETWORKS CAN HELP US WITH 978 00:46:33,642 --> 00:46:34,276 ADDRESSING THE GAPS IN CLINICAL 979 00:46:34,276 --> 00:46:41,083 CARE. 980 00:46:41,083 --> 00:46:43,318 IN REAL TIME AND REAL-WORLD 981 00:46:43,318 --> 00:46:43,585 SETTINGS. 982 00:46:43,585 --> 00:46:47,423 WE HAVE RESEARCHERS MONITORING 983 00:46:47,423 --> 00:46:49,758 CLINICAL STUDIES TO ENSURE 984 00:46:49,758 --> 00:46:51,326 INCLUSION AND ESTABLISH NEW 985 00:46:51,326 --> 00:46:53,328 COLLABORATIONS WITHIN 986 00:46:53,328 --> 00:46:54,830 COMMUNITIES AND REVISIT 987 00:46:54,830 --> 00:46:59,868 OPPORTUNITIES TO TRANSLATE AND 988 00:46:59,868 --> 00:47:00,969 IMPLEMENT WITHIN AND ACROSS 989 00:47:00,969 --> 00:47:02,571 COMMUNITIES AND STAFF ARE 990 00:47:02,571 --> 00:47:04,573 WORKING HARD TO IDENTIFY NEEDS 991 00:47:04,573 --> 00:47:07,876 AND RESEARCH GAPS THAT CAN HELP 992 00:47:07,876 --> 00:47:11,547 WITH IMPROVING CLINICAL CARE AS 993 00:47:11,547 --> 00:47:16,552 WELL AS ORIENTING CLINICAL 994 00:47:16,552 --> 00:47:19,855 RESEARCHERS TO NIH AND NIDCR 995 00:47:19,855 --> 00:47:20,656 EXPECTATIONS OVER THE LIFE SPAN 996 00:47:20,656 --> 00:47:23,559 OF CLINICAL STUDIES AND 997 00:47:23,559 --> 00:47:25,093 SPECIFICALLY HAVE DONE A RECENT 998 00:47:25,093 --> 00:47:28,797 SYSTEMATIC REVIEW OF ALL OF OUR 999 00:47:28,797 --> 00:47:30,132 FUNDED CLINICAL TRIALS TO 1000 00:47:30,132 --> 00:47:31,667 BENCHMARK OUR CURRENT 1001 00:47:31,667 --> 00:47:33,202 DISTRIBUTIONS, WHERE ARE WE WITH 1002 00:47:33,202 --> 00:47:35,103 UNDER SERVED POPULATIONS WITH 1003 00:47:35,103 --> 00:47:36,238 NETWORK INVOLVEMENT AND RESEARCH 1004 00:47:36,238 --> 00:47:37,372 AREAS. 1005 00:47:37,372 --> 00:47:40,776 WE'RE BUILDING WEB-BASED 1006 00:47:40,776 --> 00:47:41,343 CLINICAL-BASED RESOURCES. 1007 00:47:41,343 --> 00:47:42,010 WE'RE HOPING THESE WILL BE 1008 00:47:42,010 --> 00:47:46,415 RELEASED ON THE NEXT YEAR. 1009 00:47:46,415 --> 00:47:47,916 TO EDUCATE THE PUBLIC AND 1010 00:47:47,916 --> 00:47:49,384 RESEARCH COMMUNITY ON THE VALUE 1011 00:47:49,384 --> 00:47:55,023 AND METHOD RELATED TO BIOMEDICAL 1012 00:47:55,023 --> 00:47:56,859 RESEARCH AND DEVELOPING 1013 00:47:56,859 --> 00:47:59,328 ENROLLMENT AND RETENTION POLICY 1014 00:47:59,328 --> 00:48:07,870 AN ACCRUAL POLICY TO MAXIMIZE 1015 00:48:07,870 --> 00:48:09,872 OUR RETURN ON INVESTMENT. 1016 00:48:09,872 --> 00:48:11,540 THERE ARE MULTIPLE STUDIES AND 1017 00:48:11,540 --> 00:48:12,307 SCIENTIFIC ADVANCES THAT HAVE 1018 00:48:12,307 --> 00:48:14,376 BEEN ADDRESSING GAPS IN CLINICAL 1019 00:48:14,376 --> 00:48:16,411 CARE IN THE COMMUNITY. 1020 00:48:16,411 --> 00:48:20,082 AND THESE INCLUDE PREDICTING 1021 00:48:20,082 --> 00:48:23,218 DENTAL CARRIES IN YOUNG CHILDREN 1022 00:48:23,218 --> 00:48:25,254 AND REDUCING HEALTH DISPARITIES. 1023 00:48:25,254 --> 00:48:29,525 LOOKING AT HOW DENTAL VISITS CAN 1024 00:48:29,525 --> 00:48:31,527 INCREASE SUPPORT FROM PEDIATRIC 1025 00:48:31,527 --> 00:48:34,129 PROVIDERS AND WE TALKED ABOUT 1026 00:48:34,129 --> 00:48:36,198 EARLIER OUR COMMUNITY-BASED 1027 00:48:36,198 --> 00:48:37,199 PARTICIPATORY RESEARCH 1028 00:48:37,199 --> 00:48:38,800 CONSORTIUM IN THE CONTEXT OF 1029 00:48:38,800 --> 00:48:47,543 ADAPT. 1030 00:48:47,543 --> 00:48:50,712 WE'RE WORKING TO ENGAGE WHOLE 1031 00:48:50,712 --> 00:48:51,880 PERSON HEALTH AND ADVOCACY GROUP 1032 00:48:51,880 --> 00:48:56,118 AND TO CURATE A PLATFORM WHERE 1033 00:48:56,118 --> 00:49:06,528 THE MANNER AND TRAINING 1034 00:49:07,930 --> 00:49:15,871 INDIVIDUALS TO PROVIDE AND DO 1035 00:49:15,871 --> 00:49:16,738 CLINICAL RESEARCH. 1036 00:49:16,738 --> 00:49:20,275 HOW ARE WE TRAINING? 1037 00:49:20,275 --> 00:49:24,680 WE HAVE 60 DUAL-DEGREE 1038 00:49:24,680 --> 00:49:29,551 PREDOCTORAL SCIENTISTS AND 1039 00:49:29,551 --> 00:49:31,887 HERE'S JUST QUICK SCIENCE 1040 00:49:31,887 --> 00:49:33,689 ADVANCES. 1041 00:49:33,689 --> 00:49:33,922 CARIES. 1042 00:49:33,922 --> 00:49:33,989 1043 00:49:36,124 --> 00:49:39,628 THERE'S RANDOMIZED TRIAL THAT 1044 00:49:39,628 --> 00:49:40,596 DEMONSTRATED PEDIATRIC 1045 00:49:40,596 --> 00:49:41,597 CLINICIANS CAN INTEGRATE ORAL 1046 00:49:41,597 --> 00:49:43,966 HEALTH SERVICES INTO THEIR WORK 1047 00:49:43,966 --> 00:49:45,534 FLOW DURING WELL CHILD VISITS 1048 00:49:45,534 --> 00:49:47,536 AND IT WORKS JUST FINE. 1049 00:49:47,536 --> 00:49:52,541 THIS WAS WORK SPEARHEADED BY 1050 00:49:52,541 --> 00:49:57,646 NELSON ET AL. 1051 00:49:57,646 --> 00:50:01,550 THERE WAS A COST-EFFECTIVENESS 1052 00:50:01,550 --> 00:50:06,221 STUDY FROM JANUSZ ET AL. TO LOOK 1053 00:50:06,221 --> 00:50:09,157 AT RISK-BASED APPROACHES AS A 1054 00:50:09,157 --> 00:50:11,526 STRATEGY THAT LOOKED PROMISING. 1055 00:50:11,526 --> 00:50:13,996 AND QUANTITATIVE STUDIES AND 1056 00:50:13,996 --> 00:50:16,398 HERE'S A FLUORIDE FOCUSSED STUDY 1057 00:50:16,398 --> 00:50:17,532 PERFECT THE GROUP THAT 1058 00:50:17,532 --> 00:50:22,037 HIGHLIGHTS THE NEED FOR IMPROVED 1059 00:50:22,037 --> 00:50:23,071 EDUCATION AND TRAINING IN 1060 00:50:23,071 --> 00:50:23,672 EVIDENCE BASED COMMUNICATION. 1061 00:50:23,672 --> 00:50:27,876 THIS WILL IMPROVE PRIMARY CARE. 1062 00:50:27,876 --> 00:50:29,411 WE ALSO HAVE EXAMPLES HOW DATA 1063 00:50:29,411 --> 00:50:33,115 AND PRIMARY CARE COME TOGETHER 1064 00:50:33,115 --> 00:50:36,852 TO IMPROVE ORAL HEALTH. 1065 00:50:36,852 --> 00:50:41,757 SPECIFICALLY HERE WE'RE 1066 00:50:41,757 --> 00:50:47,863 HIGHLIGHTING THE HEATON PROJECT 1067 00:50:47,863 --> 00:50:49,631 USING COMPUTATIONAL APPROACHES 1068 00:50:49,631 --> 00:50:52,100 TO MODEL WHAT'S HAPPENING OUT IN 1069 00:50:52,100 --> 00:50:54,736 THE COMMUNITY. 1070 00:50:54,736 --> 00:50:55,871 SPECIFICALLY LOOKING AT HOUSING 1071 00:50:55,871 --> 00:51:06,281 DEVELOPMENTS IN BOSTON. 1072 00:51:09,484 --> 00:51:11,019 TOE UNDERSTAND WHAT CAN LEAD TO 1073 00:51:11,019 --> 00:51:13,855 IMPROVED ORAL HEALTH OUTCOMES. 1074 00:51:13,855 --> 00:51:15,857 ANOTHER EXAMPLE ARE USE OF 1075 00:51:15,857 --> 00:51:17,526 DATA-DRIVEN APPROACHES TO HELP 1076 00:51:17,526 --> 00:51:19,594 IN CLINICAL CARE. 1077 00:51:19,594 --> 00:51:22,164 HERE SOFTWARE BASED 1078 00:51:22,164 --> 00:51:24,132 OBSERVATIONAL CODING WAS USED TO 1079 00:51:24,132 --> 00:51:26,968 HELP WITH EVALUATION OF 1080 00:51:26,968 --> 00:51:27,703 PEDIATRIC DENTAL PAIN, ANXIETY 1081 00:51:27,703 --> 00:51:32,074 AND FEAR. 1082 00:51:32,074 --> 00:51:34,209 SO WE ARE WORKING TO FOSTER 1083 00:51:34,209 --> 00:51:36,445 CLINICAL CARE RESEARCH, TO 1084 00:51:36,445 --> 00:51:40,382 FORWARD DATA AND TO ESTABLISH 1085 00:51:40,382 --> 00:51:40,782 NID 1086 00:51:40,782 --> 00:51:43,285 NIDCR-FUNDED NETWORK AS A KEY 1087 00:51:43,285 --> 00:51:46,154 AND CENTRAL PART OF NIH WIDE 1088 00:51:46,154 --> 00:51:47,556 COMMUNITIES ADVANCING RESEARCH 1089 00:51:47,556 --> 00:51:51,860 EQUITY OR THE CARE NETWORK 1090 00:51:51,860 --> 00:51:53,061 DR. BERTAGNOLLI SHARED WITH US 1091 00:51:53,061 --> 00:51:57,065 WHEN VISITING AT LAST COUNCIL. 1092 00:51:57,065 --> 00:51:58,967 THE BOTTOM LINE IN CLOSING IS 1093 00:51:58,967 --> 00:52:01,870 THAT WE ARE WORKING COLLECTIVELY 1094 00:52:01,870 --> 00:52:03,872 THROUGH THE RESEARCH WE DO FROM 1095 00:52:03,872 --> 00:52:06,842 THE MOLECULAR LEVEL OUT TO THE 1096 00:52:06,842 --> 00:52:07,442 POPULATION LEVEL TOWARDS ORAL 1097 00:52:07,442 --> 00:52:11,146 HEALTH FOR ALL. 1098 00:52:11,146 --> 00:52:11,947 AND THAT MEANS ORAL HEALTH FOR 1099 00:52:11,947 --> 00:52:14,483 ALL OF US. 1100 00:52:14,483 --> 00:52:18,720 SO I'M GOING IT TAKE THIS MOMENT 1101 00:52:18,720 --> 00:52:23,892 TO INTRODUCE THE ALL OF US 1102 00:52:23,892 --> 00:52:28,497 RESEARCH PROGRAM AND IT IS MY 1103 00:52:28,497 --> 00:52:30,866 DISTINCT PLEASURE TO SHARE 1104 00:52:30,866 --> 00:52:31,867 SHERRI SCHULLY WILL BE JOINING 1105 00:52:31,867 --> 00:52:34,136 US FROM THE ALL OF US PROGRAM. 1106 00:52:34,136 --> 00:52:37,272 SHE SERVES AS DEPUTY CHIEF 1107 00:52:37,272 --> 00:52:37,906 MEDICAL AND SCIENTIFIC OFFICER 1108 00:52:37,906 --> 00:52:39,040 FOR ALL OF US. 1109 00:52:39,040 --> 00:52:42,010 PRIOR TO THIS ROLE, SHE WAS A 1110 00:52:42,010 --> 00:52:44,012 TEAM LEAD AND SENIOR ADVISER IN 1111 00:52:44,012 --> 00:52:47,215 THING OFF OF DISEASE PREVENTION 1112 00:52:47,215 --> 00:52:48,950 HERE AT NIH AND HER RESEARCH 1113 00:52:48,950 --> 00:52:53,555 TRDZ INCLUDE GENOMICS, 1114 00:52:53,555 --> 00:52:56,691 PERSONALIZED MEDICINE AND 1115 00:52:56,691 --> 00:52:59,127 GENETIC AND GENOMIC INFORMATION 1116 00:52:59,127 --> 00:53:03,131 INTO CLINICAL AND PUBLIC HEALTH 1117 00:53:03,131 --> 00:53:03,832 PRACTICES. 1118 00:53:03,832 --> 00:53:05,934 HER Ph.D. WAS IN BIOLOGICAL 1119 00:53:05,934 --> 00:53:09,471 SCIENCES WITH A CONCENTRATION OF 1120 00:53:09,471 --> 00:53:10,939 POPULATION GENETICS AND 1121 00:53:10,939 --> 00:53:12,841 RESOURCED HER BACHELOR'S IN 1122 00:53:12,841 --> 00:53:14,543 ZOOLOGY WITH A MINOR IN 1123 00:53:14,543 --> 00:53:15,177 CHEMISTRY FROM LOUISIANA STATE 1124 00:53:15,177 --> 00:53:19,881 UNIVERSITY. 1125 00:53:19,881 --> 00:53:20,916 IT IS MY PLEASURE TO HAVE 1126 00:53:20,916 --> 00:53:31,359 DR. SCHULLY JOIN US TODAY. 1127 00:53:57,886 --> 00:53:58,920 >> THANK YOU AND I'M GOING TO 1128 00:53:58,920 --> 00:53:59,588 SHARE MY SLIDES. 1129 00:53:59,588 --> 00:54:01,590 I WANT YOU TO KNOW THERE ARE A 1130 00:54:01,590 --> 00:54:06,895 LOT OF SLIDES HERE BUT I REALLY 1131 00:54:06,895 --> 00:54:12,868 WANT TO EMPHASIZE FOR SOME DATA 1132 00:54:12,868 --> 00:54:14,269 ACCESS SLIDES I'LL GO FAST 1133 00:54:14,269 --> 00:54:15,871 THROUGH THOSE I WANT PEOPLE TO 1134 00:54:15,871 --> 00:54:17,706 HAVE ACCESS TO OUR DATA AND 1135 00:54:17,706 --> 00:54:21,009 DIRECT YOUR TRAINEES TO OUR DATA 1136 00:54:21,009 --> 00:54:22,944 AS WELL AS YOUR OTHER CONTACTS. 1137 00:54:22,944 --> 00:54:27,949 DEFINITELY DO WANT TO MAKE SURE 1138 00:54:27,949 --> 00:54:35,257 EVERYONE HAS THAT. 1139 00:54:35,257 --> 00:54:38,193 I'M THE DEPUTY CHIEF MEDICAL AND 1140 00:54:38,193 --> 00:54:39,761 SCIENTIFIC OFFICER FOR THE ALL 1141 00:54:39,761 --> 00:54:41,596 OF US PROGRAM AND HERE FOR 1142 00:54:41,596 --> 00:54:43,565 LEADERSHIP AS A WHOLE. 1143 00:54:43,565 --> 00:54:46,768 WE'VE BEEN TALKING A LOT ABOUT 1144 00:54:46,768 --> 00:54:47,469 POTENTIAL COLLABORATIONS. 1145 00:54:47,469 --> 00:54:48,136 I'LL GIVE A LITTLE BIT OF 1146 00:54:48,136 --> 00:54:53,308 BACKGROUND ON THE PROGRAM. 1147 00:54:53,308 --> 00:55:00,682 OUR CURRENT DATA WHAT'S 1148 00:55:00,682 --> 00:55:05,587 AVAILABLE NOW AND WHERE ARE 1149 00:55:05,587 --> 00:55:07,055 COLLABORATIONS OPPORTUNITIES 1150 00:55:07,055 --> 00:55:08,056 WITH DENTAL ORAL CRANIOFACIAL 1151 00:55:08,056 --> 00:55:08,623 RESEARCH. 1152 00:55:08,623 --> 00:55:11,359 OUR MISSION IS TO ACCELERATE 1153 00:55:11,359 --> 00:55:14,095 HEALTH RESEARCH AND MEDICAL 1154 00:55:14,095 --> 00:55:14,696 BREAKTHROUGHS ENABLIZING 1155 00:55:14,696 --> 00:55:15,864 TREATMENT AND CARE FOR YOU WILL 1156 00:55:15,864 --> 00:55:17,499 OF US. 1157 00:55:17,499 --> 00:55:18,967 WE DO THIS IN THREE WAYS. 1158 00:55:18,967 --> 00:55:21,670 THE FIRST IS NURTURING 1159 00:55:21,670 --> 00:55:24,072 PARTNERSHIPS WITH DECADES WITH 1160 00:55:24,072 --> 00:55:26,341 AT LEAST $1 MILLION WHO REFLECT 1161 00:55:26,341 --> 00:55:27,142 THE DIVERSITY OF THE UNITED 1162 00:55:27,142 --> 00:55:28,576 STATES AS A WHOLE. 1163 00:55:28,576 --> 00:55:31,279 SECOND, WE WANT TO DELIVER ONE 1164 00:55:31,279 --> 00:55:34,082 OF THE LARGEST RICHEST 1165 00:55:34,082 --> 00:55:35,350 BIOMEDICAL DATA SETS AS BROADLY 1166 00:55:35,350 --> 00:55:38,586 AVAILABLE AND SECURE SO OUR DATA 1167 00:55:38,586 --> 00:55:41,556 THAT WAS DONATED BY PARTICIPANTS 1168 00:55:41,556 --> 00:55:44,159 ISN'T IDENTIFIABLE AND CAN BE 1169 00:55:44,159 --> 00:55:46,962 PUT OUT THERE IN A BROAD WAY. 1170 00:55:46,962 --> 00:55:50,632 FINALLY JUST BECAUSE WE HAVE THE 1171 00:55:50,632 --> 00:55:51,433 AMAZING PARTNERSHIPS AND 1172 00:55:51,433 --> 00:55:53,368 BUILDING THIS AMAZING 1173 00:55:53,368 --> 00:55:54,002 INFRASTRUCTURE DOESN'T MEAN 1174 00:55:54,002 --> 00:55:55,870 PEOPLE WILL NECESSARY COME TO 1175 00:55:55,870 --> 00:55:56,504 IT. 1176 00:55:56,504 --> 00:55:58,073 WE'RE HOPING TO CATALYZE AN ECO 1177 00:55:58,073 --> 00:55:59,274 SYSTEM OF COMMUNITIES, 1178 00:55:59,274 --> 00:56:01,910 RESEARCHERS AND FUNDERS WHO MAKE 1179 00:56:01,910 --> 00:56:05,780 ALL OF US AN INDISPENSABLE PART 1180 00:56:05,780 --> 00:56:07,882 OF RESEARCH AND SEE THIS IS A 1181 00:56:07,882 --> 00:56:10,919 REALLY AMAZING RESEARCH AND CAN 1182 00:56:10,919 --> 00:56:13,655 ANSWER LOTS OF QUESTIONS FOR 1183 00:56:13,655 --> 00:56:15,857 LOTS OF CONDITIONS. 1184 00:56:15,857 --> 00:56:18,827 THERE ARE SOME HOLES WE CAN FILL 1185 00:56:18,827 --> 00:56:19,861 INCLUDING MORE DENTAL RECORDS 1186 00:56:19,861 --> 00:56:21,663 AND THINGS LIKE THAT BUT WE CAN 1187 00:56:21,663 --> 00:56:22,397 LEAVE THAT FOR THE DISCUSSION 1188 00:56:22,397 --> 00:56:24,766 PART TOWARDS THE END. 1189 00:56:24,766 --> 00:56:27,469 I DO WANT TO START BY TALKING 1190 00:56:27,469 --> 00:56:29,204 OUR CORE VALUES. 1191 00:56:29,204 --> 00:56:32,340 WE WANT TO MAKE SURE THAT WE ARE 1192 00:56:32,340 --> 00:56:34,576 STICKING TO THESE CORE VALUES. 1193 00:56:34,576 --> 00:56:36,177 HOPEFULLY YOU'LL SEE WHAT WE 1194 00:56:36,177 --> 00:56:40,382 BUILT SO FAR AND REFLECT THE 1195 00:56:40,382 --> 00:56:40,715 CORE VALUES. 1196 00:56:40,715 --> 00:56:42,617 PARTS TO ALL OF US IS OPEN TO 1197 00:56:42,617 --> 00:56:42,951 ALL. 1198 00:56:42,951 --> 00:56:43,852 WE'RE NOT TURNING PEOPLE AWAY. 1199 00:56:43,852 --> 00:56:49,057 IT'S OPEN. 1200 00:56:49,057 --> 00:56:52,093 WE WANT PROPERTIES TO REFLECT 1201 00:56:52,093 --> 00:56:54,529 THE RICH DIVERSITY OF THE UNITED 1202 00:56:54,529 --> 00:56:54,763 STATES. 1203 00:56:54,763 --> 00:56:57,198 MOST DATA TO DATE HAS NOT BEEN 1204 00:56:57,198 --> 00:56:58,066 REPRESENTATIVE OF INDIVIDUALS IN 1205 00:56:58,066 --> 00:57:02,237 THE UNITED STATES AND THE CARE 1206 00:57:02,237 --> 00:57:06,775 BASED OFF THAT EVIDENCE IS ONE 1207 00:57:06,775 --> 00:57:17,685 SIZE FITS RAALL AND OUR PARTNER 1208 00:57:17,685 --> 00:57:18,720 HAVE INVOLVED AND TRUST WILL BE 1209 00:57:18,720 --> 00:57:20,355 EARNED THROUGH 42 TRANSPARENCY 1210 00:57:20,355 --> 00:57:21,489 AND MAKING SURE WE'RE 1211 00:57:21,489 --> 00:57:22,190 INTERACTIVE WITH OUR 1212 00:57:22,190 --> 00:57:22,791 PARTICIPANTS AND BEING CLEAR 1213 00:57:22,791 --> 00:57:29,264 WITH THEM. 1214 00:57:29,264 --> 00:57:31,733 PARTICIPANTS HAVE ACCESS TO 1215 00:57:31,733 --> 00:57:33,568 THEIR INFORMATION AND DATA 1216 00:57:33,568 --> 00:57:35,270 AVAILABLE BROADLY FOR RESEARCH 1217 00:57:35,270 --> 00:57:37,672 PURPOSES WITH SECURITY AT THE 1218 00:57:37,672 --> 00:57:39,874 HIGHEST IMPORTANCE BECAUSE OUR 1219 00:57:39,874 --> 00:57:40,775 PARTICIPANTS DONATE TO THE DATA 1220 00:57:40,775 --> 00:57:45,213 AND WE NEED TO PROTECT IT AND 1221 00:57:45,213 --> 00:57:46,381 WILL BE A CATALYST FOR CHANGE IN 1222 00:57:46,381 --> 00:57:47,582 RESEARCH AND HOPE YOU STARTED TO 1223 00:57:47,582 --> 00:57:51,152 SEE WE MADE THE CHANGE HAPPEN. 1224 00:57:51,152 --> 00:57:53,421 I'LL GIVE YOU A LITTLE BIT OF A 1225 00:57:53,421 --> 00:57:54,122 BACKGROUND OF THE PROGRAM. 1226 00:57:54,122 --> 00:58:00,595 TO DATE, WE CURRENTLY HAVE OVER 1227 00:58:00,595 --> 00:58:01,863 834,000 PARTICIPANTS ENROLLED OR 1228 00:58:01,863 --> 00:58:04,265 CONSENTED TO BE PART OF THE 1229 00:58:04,265 --> 00:58:04,966 PROGRAM. 1230 00:58:04,966 --> 00:58:08,369 AND 567,000 INDIVIDUALS HAVE 1231 00:58:08,369 --> 00:58:09,771 COMPLETED WHAT WE CALL THE 1232 00:58:09,771 --> 00:58:12,974 INITIAL STEPS OF THE PROGRAM. 1233 00:58:12,974 --> 00:58:14,709 COMPLETED THE FIRST THREE 1234 00:58:14,709 --> 00:58:16,511 SURVEYS, GIVEN A BIO SAMPLE OF 1235 00:58:16,511 --> 00:58:20,915 SOME SORT AND GIVEN US PHYSICAL 1236 00:58:20,915 --> 00:58:22,016 MEASUREMENTS VERY BASIC AND I'LL 1237 00:58:22,016 --> 00:58:23,885 GO THROUGH WHAT THOSE ARE. 1238 00:58:23,885 --> 00:58:26,688 WE HAVE LINK TO ELECTRONIC 1239 00:58:26,688 --> 00:58:27,989 HEALTH RECORDS FROM OVER 453,000 1240 00:58:27,989 --> 00:58:28,289 PARTICIPANT. 1241 00:58:28,289 --> 00:58:30,191 WE'RE HOPING TO CLOSE THE GAP 1242 00:58:30,191 --> 00:58:33,661 BETWEEN THE 567,000 AND 453,000 1243 00:58:33,661 --> 00:58:38,867 BUT WITH THE FEDERATED HEALTH 1244 00:58:38,867 --> 00:58:41,803 CARE SYSTEM IT'S DIFFICULT SO 1245 00:58:41,803 --> 00:58:44,772 THE E.H.R. LAGS A LITTLE BIT 1246 00:58:44,772 --> 00:58:47,642 BEHIND AND HAVE 587,000 WITH 1247 00:58:47,642 --> 00:58:53,515 SPECIMENS AT THE MAYO CLINIC. 1248 00:58:53,515 --> 00:58:54,716 WE HAVE PARTICIPANTS IN ALL 50 1249 00:58:54,716 --> 00:58:59,087 STATES. 1250 00:58:59,087 --> 00:59:02,223 AS WELL AS MANY U.S. TERRITORY. 1251 00:59:02,223 --> 00:59:04,826 THE DARKER YELLOW COLORS 1252 00:59:04,826 --> 00:59:10,532 INDICATE WHERE WE HAVE HIGHER 1253 00:59:10,532 --> 00:59:12,367 POPULATIONS AND REGIONAL MEDICAL 1254 00:59:12,367 --> 00:59:14,435 CENTERS THAT HAVE ENROLLMENT 1255 00:59:14,435 --> 00:59:18,940 CENTERS VERSUS OUR JOIN ALL OF 1256 00:59:18,940 --> 00:59:20,475 US.org SELF-JOURNEY. 1257 00:59:20,475 --> 00:59:25,780 SO ANYONE CAN JOIN FROM ANYWHERE 1258 00:59:25,780 --> 00:59:32,487 IN THE UNITED STATES BUT AND 1259 00:59:32,487 --> 00:59:35,657 THERE'S MORE OF A HANDS ON 1260 00:59:35,657 --> 00:59:36,291 EXPERIENCE. 1261 00:59:36,291 --> 00:59:38,893 WE WANT TO REFLECT THE BROAD 1262 00:59:38,893 --> 00:59:39,527 DIVERSITY OF THE UNITED STATES. 1263 00:59:39,527 --> 00:59:41,829 FOR ALL OF US WE'RE TRYING TO 1264 00:59:41,829 --> 00:59:43,898 COLLECT DATA ON THOSE WHO HAVE 1265 00:59:43,898 --> 00:59:47,101 BEEN UNDER REPRESENTED IN BIO 1266 00:59:47,101 --> 00:59:47,669 MEDICAL RESEARCH. 1267 00:59:47,669 --> 00:59:50,371 THAT'S NOT ONLY RACIAL AND 1268 00:59:50,371 --> 00:59:52,373 ETHNIC MINORITIES BUT ALSO 1269 00:59:52,373 --> 00:59:54,542 THINKING ABOUT THOSE WHO ARE 1270 00:59:54,542 --> 00:59:56,511 SEXUAL GENDER MINORITIES. 1271 00:59:56,511 --> 00:59:58,746 THOSE LOW INCOME OR MAY HAVE A 1272 00:59:58,746 --> 01:00:00,281 DISABILITY, LOW EDUCATION 1273 01:00:00,281 --> 01:00:04,452 ATTAINMENT, RURAL VERSUS URBAN 1274 01:00:04,452 --> 01:00:04,886 POPULATIONS. 1275 01:00:04,886 --> 01:00:06,454 WE'RE STRIVING TO BE 75% OF WHAT 1276 01:00:06,454 --> 01:00:09,090 WE CALL UNDER REPRESENTED IN BIO 1277 01:00:09,090 --> 01:00:10,959 MEDICAL RESEARCH WITH 50% OF 1278 01:00:10,959 --> 01:00:13,294 THAT ACTUALLY BEING RACIAL AND 1279 01:00:13,294 --> 01:00:14,128 ETHNIC MINORITIES. 1280 01:00:14,128 --> 01:00:15,897 SO WHEN YOU THINK ABOUT SOME OF 1281 01:00:15,897 --> 01:00:16,831 THE THINGS THAT JENNIFER 1282 01:00:16,831 --> 01:00:19,867 MENTIONED IN HER OPENING TALK, 1283 01:00:19,867 --> 01:00:21,569 WE'RE REALLY BRINGING IN THOSE 1284 01:00:21,569 --> 01:00:22,770 PARTICIPANTS THAT MAY HAVE THE 1285 01:00:22,770 --> 01:00:26,174 SAME GAP FOR DENTAL AND ORAL 1286 01:00:26,174 --> 01:00:28,843 CARE AND RESEARCH AND SO I THINK 1287 01:00:28,843 --> 01:00:30,211 THIS MIGHT BE A GOOD OPPORTUNITY 1288 01:00:30,211 --> 01:00:31,946 TO REACH SOME POPULATIONS THAT 1289 01:00:31,946 --> 01:00:39,053 HAVEN'T BEEN REACHED BEFORE. 1290 01:00:39,053 --> 01:00:42,490 WHAT I'LL BE TRA TALKING ABOUT 1291 01:00:42,490 --> 01:00:44,525 SPECIFICALLY FOR ADULTS, SO 18 1292 01:00:44,525 --> 01:00:45,293 YEARS AND OLDER. 1293 01:00:45,293 --> 01:00:47,862 WE STARTED PEDIATRIC ENROLLMENT. 1294 01:00:47,862 --> 01:00:48,730 I'LL TALK A LITTLE BIT ABOUT 1295 01:00:48,730 --> 01:00:49,330 THAT AND WHERE WE ARE TOWARDS 1296 01:00:49,330 --> 01:00:54,769 THE END. 1297 01:00:54,769 --> 01:00:55,903 I'LL START WITH E.H.R. 1298 01:00:55,903 --> 01:00:59,674 THE CONSENT IS INTERACTIVE VIDEO 1299 01:00:59,674 --> 01:01:02,844 ONLINE CONSENT. 1300 01:01:02,844 --> 01:01:04,145 DURING THAT CONSENT PARTICIPANTS 1301 01:01:04,145 --> 01:01:06,648 AUTHORIZE TO SHARE THEIR 1302 01:01:06,648 --> 01:01:07,282 ELECTRONIC HEALTH RECORD DATA 1303 01:01:07,282 --> 01:01:07,815 WITH RESEARCHERS. 1304 01:01:07,815 --> 01:01:10,652 RIGHT NOW WHAT WE'RE ABLE TO 1305 01:01:10,652 --> 01:01:12,954 GRAB FROM THE E.H.R. ARE 1306 01:01:12,954 --> 01:01:15,056 DEMOGRAPHICS, VISITS, DIAGNOSES, 1307 01:01:15,056 --> 01:01:16,057 PROCEDURES, MEDICATIONS, LAB 1308 01:01:16,057 --> 01:01:18,826 VISITS AND VITAL SIGNS. 1309 01:01:18,826 --> 01:01:23,665 WE'RE LOOKING TO EXPAND ON THAT 1310 01:01:23,665 --> 01:01:25,833 ESPECIALLY AS MACHINE LEARNING 1311 01:01:25,833 --> 01:01:26,567 AND ARTIFICIAL INTELLIGENCE GETS 1312 01:01:26,567 --> 01:01:28,936 BETTER TO INCLUDE CLINICAL NOTES 1313 01:01:28,936 --> 01:01:30,938 AND REPORTS, MENTAL HEALTH 1314 01:01:30,938 --> 01:01:33,408 REPORTS, SUBSTANCE ABUSE, MORE 1315 01:01:33,408 --> 01:01:35,677 LABORATORY RESULTS IN THE 1316 01:01:35,677 --> 01:01:35,910 VALUES. 1317 01:01:35,910 --> 01:01:38,079 AS YOU GUYS KNOW THOSE ARE 1318 01:01:38,079 --> 01:01:41,149 TYPICALLY IN PDF FORM OR HAVE 1319 01:01:41,149 --> 01:01:41,816 HIGHLY IDENTIFIABLE INFORMATION 1320 01:01:41,816 --> 01:01:42,984 ON THEM. 1321 01:01:42,984 --> 01:01:45,486 SO IT'S GOING TO TAKE A LITTLE 1322 01:01:45,486 --> 01:01:49,524 BIT MORE TO LOOK ACROSS 687,000 1323 01:01:49,524 --> 01:01:50,692 INDIVIDUALS E.H.R.s AND PULL 1324 01:01:50,692 --> 01:01:53,695 THAT INFORMATION IN A WAY THAT 1325 01:01:53,695 --> 01:01:55,897 REALLY SCRUBS IT OF IDENTIFYING 1326 01:01:55,897 --> 01:01:58,333 INFORMATION AND MAKES IT 1327 01:01:58,333 --> 01:01:59,667 DE-IDENTIFIED FOR OUR BROAD 1328 01:01:59,667 --> 01:02:07,909 RESEARCH PURPOSES. 1329 01:02:07,909 --> 01:02:10,912 WE HAVE PARTICIPANT PROVIDED 1330 01:02:10,912 --> 01:02:21,422 INFORMATION AND LIFE TIME AND 1331 01:02:22,156 --> 01:02:25,560 AFTER ENROLLMENT THEY GET OTHER 1332 01:02:25,560 --> 01:02:26,327 SURVEYS INCLUDING HEALTH CARE 1333 01:02:26,327 --> 01:02:27,729 ACCESS AND UTILIZING AND 1334 01:02:27,729 --> 01:02:30,598 PERSONAL AND FAMILY HEALTH 1335 01:02:30,598 --> 01:02:34,001 HISTORY, SOCIAL DETERMINATES, 1336 01:02:34,001 --> 01:02:34,602 EMOTIO 1337 01:02:34,602 --> 01:02:38,806 EMOTIO 1338 01:02:38,806 --> 01:02:39,474 EMOTIONAL HEALTH HISTORY AND 1339 01:02:39,474 --> 01:02:43,444 WELL BEING AND AD HOC SURVEYS SO 1340 01:02:43,444 --> 01:02:45,546 WHEN THE COVID-19 PANDEMIC 1341 01:02:45,546 --> 01:02:47,348 HAPPENED WE HAD SURVEYS THAT 1342 01:02:47,348 --> 01:02:49,517 ASKED PARTICIPANTS ABOUT THEIR 1343 01:02:49,517 --> 01:02:51,252 EXPERIENCE WITH COVID-19 GOING 1344 01:02:51,252 --> 01:02:52,387 BEYOND SYMPTOMOLOGY AND WHO HAD 1345 01:02:52,387 --> 01:02:54,288 TESTED POSITIVE FOR COVID COVID 1346 01:02:54,288 --> 01:02:55,623 AND THINGS LIKE THAT BUT ASKING 1347 01:02:55,623 --> 01:02:58,860 WHAT WITH WAS THE IMPACT ON OUR 1348 01:02:58,860 --> 01:02:59,694 INDIVIDUAL PARTICIPANTS. 1349 01:02:59,694 --> 01:03:02,130 DID THEY LOSE THEIR JOB BECAUSE 1350 01:03:02,130 --> 01:03:04,065 THEY COULDN'T BE IN PERSON? 1351 01:03:04,065 --> 01:03:05,767 DID THEY LOSE INSURANCE? 1352 01:03:05,767 --> 01:03:08,469 WERE THEY SOCIALLY ISOLATED OR 1353 01:03:08,469 --> 01:03:09,337 HAVING MENTAL HEALTH ISSUES 1354 01:03:09,337 --> 01:03:10,304 ABOUT IT? 1355 01:03:10,304 --> 01:03:12,974 WE HAVE A DYNAMIC PLATFORM WHERE 1356 01:03:12,974 --> 01:03:17,178 WE CAN GET ANSWERS TO PUBLIC 1357 01:03:17,178 --> 01:03:17,912 HEALTH EMERGENCIES HAPPENING IN 1358 01:03:17,912 --> 01:03:28,423 THINGS LIKE THAT IN REAL TIME. 1359 01:03:38,733 --> 01:03:40,535 WE GOT BLOOD PRESSURE, HIP, 1360 01:03:40,535 --> 01:03:44,639 WEIGHT, BMI AND HIP AND WAIST 1361 01:03:44,639 --> 01:03:49,644 SCIRCUMFERENCE AND THEY GET A 1362 01:03:49,644 --> 01:03:51,879 NICE REPORT AND GUIDELINES FOR 1363 01:03:51,879 --> 01:03:53,414 VARIOUS COMPONENTS. 1364 01:03:53,414 --> 01:03:55,850 WE ALSO HAVE BIO SPECIMENS WE 1365 01:03:55,850 --> 01:03:58,486 ARE COLLECTING. 1366 01:03:58,486 --> 01:04:01,422 WE TYPICALLY COLLECT BLOOD AND 1367 01:04:01,422 --> 01:04:03,891 URINE FROM PARTICIPANTS AND 1368 01:04:03,891 --> 01:04:05,159 LISTED OUR STANDARD BLOOD AND 1369 01:04:05,159 --> 01:04:07,862 URINE COLLECT. 1370 01:04:07,862 --> 01:04:09,096 IF WE CANNOT COLLECT BLOOD OR IF 1371 01:04:09,096 --> 01:04:11,132 IT'S A REMOTE PARTICIPANT WE'RE 1372 01:04:11,132 --> 01:04:15,069 DOING A SALIVA COLLECTION AND 1373 01:04:15,069 --> 01:04:17,071 USING THE COLLECTION KIT FOR DNA 1374 01:04:17,071 --> 01:04:17,338 PURPOSES. 1375 01:04:17,338 --> 01:04:19,173 WE CAN'T USE IT FOR MICROBIOME 1376 01:04:19,173 --> 01:04:21,609 RIGHT NOW BUT WITH THE SAME AS 1377 01:04:21,609 --> 01:04:23,211 SURVEYS WE CAN RECONTACT OUR 1378 01:04:23,211 --> 01:04:23,678 PARTICIPANTS. 1379 01:04:23,678 --> 01:04:26,848 IF WE DECIDED TO DO A SECOND 1380 01:04:26,848 --> 01:04:28,716 COLLECTION TO LOOK AT ORAL 1381 01:04:28,716 --> 01:04:29,717 MICROBIOME IT COULD BE DONE 1382 01:04:29,717 --> 01:04:37,091 WITHIN THIS INFRASTRUCTURE. 1383 01:04:37,091 --> 01:04:39,126 WE'RE LINKING TO VARIABLE 1384 01:04:39,126 --> 01:04:39,460 TECHNOLOGIES. 1385 01:04:39,460 --> 01:04:41,496 THIS WILL INCLUDE FITBIT AND 1386 01:04:41,496 --> 01:04:42,830 APPLE HEALTH KIT AND HOPE TO 1387 01:04:42,830 --> 01:04:45,366 HAVE ADDITIONAL INTEGRATIONS 1388 01:04:45,366 --> 01:04:47,235 WITH THINGS LIKE THE GOOGLE 1389 01:04:47,235 --> 01:04:49,904 WATCH, GARMIN, ETCETERA. 1390 01:04:49,904 --> 01:04:52,673 AND OUR CURRENT DATA INCLUDES 1391 01:04:52,673 --> 01:04:55,009 HEART RATE BY ZONE, BY MINUTE, 1392 01:04:55,009 --> 01:04:59,680 DAILY ACTIVITY, ACTIVITY STEPS 1393 01:04:59,680 --> 01:05:05,186 AND SOME SLEEP DATA. 1394 01:05:05,186 --> 01:05:08,155 WE ALSO WITH THE BIO SAYS MEN 1395 01:05:08,155 --> 01:05:14,161 COLLECTION WE DO DO BOTH WHOLE 1396 01:05:14,161 --> 01:05:16,898 GENOME AND GENOTYPING ARRAYS. 1397 01:05:16,898 --> 01:05:19,500 WE WORK WITH OUR GENOME CENTER 1398 01:05:19,500 --> 01:05:23,304 TO DO THE WHOLE GENOME 1399 01:05:23,304 --> 01:05:24,739 SEQUENCING AND THEN RETURN 1400 01:05:24,739 --> 01:05:26,641 INFORMATION TO OUR PARTICIPANTS 1401 01:05:26,641 --> 01:05:29,176 AND THAT GENOMIC RETURN STARTS 1402 01:05:29,176 --> 01:05:33,648 OUT WITH WHAT WE CALL OUR 1403 01:05:33,648 --> 01:05:34,782 GENOMICS ENGAGEMENT MODULE AND 1404 01:05:34,782 --> 01:05:35,850 I'LL GIVE MER INFORMATION ON 1405 01:05:35,850 --> 01:05:38,819 THAT AND THE SECOND IS 1406 01:05:38,819 --> 01:05:39,554 HEALTH-RELATED RESEARCH REPORTS 1407 01:05:39,554 --> 01:05:42,490 THAT TALK ABOUT HERT TRY DISEASE 1408 01:05:42,490 --> 01:05:43,958 RISK AS WELL PHARMACO GENOMIC 1409 01:05:43,958 --> 01:05:47,695 VARIANTS OR MEDICINE IN YOUR 1410 01:05:47,695 --> 01:05:55,937 DNA. 1411 01:05:55,937 --> 01:05:57,438 OUR PARTICIPANTS ARE TRUE 1412 01:05:57,438 --> 01:05:59,240 PARTNERS AND WANT TO ENGAGE IN 1413 01:05:59,240 --> 01:06:01,943 WAYS THAT GIVE THEM INFORMATION 1414 01:06:01,943 --> 01:06:03,878 ABOUT THEMSELVES AND HELP THEM 1415 01:06:03,878 --> 01:06:07,014 EMPOWER THEIR HEALTH CARE JOU 1416 01:06:07,014 --> 01:06:08,416 JOURNEY AND PARTICIPANTS HAVE 1417 01:06:08,416 --> 01:06:09,617 ACCESS TO THEIR OWN INFORMATION. 1418 01:06:09,617 --> 01:06:11,319 WITH THE RETURN OF RESULTS I 1419 01:06:11,319 --> 01:06:14,221 MENTIONED THE ENGAGEMENT PIECE 1420 01:06:14,221 --> 01:06:16,657 AND IN THE HEALTH PIECE, WE GIVE 1421 01:06:16,657 --> 01:06:19,360 VERY BROAD GENOMIC ANCESTRY BAG 1422 01:06:19,360 --> 01:06:22,330 AS WELL AS FOUR TRAITS, EAR WAX 1423 01:06:22,330 --> 01:06:26,167 TYPE, BITTER TASTE, PREFERENCE, 1424 01:06:26,167 --> 01:06:28,703 CILANTRO PREFERENCE, LACTOSE 1425 01:06:28,703 --> 01:06:31,706 INTOLERANCE AND GIVE BACK A 1426 01:06:31,706 --> 01:06:32,607 HEREDITARY RISK DISEASE REPORT 1427 01:06:32,607 --> 01:06:35,876 AND MEDICINE IN YOUR DNA REPORT. 1428 01:06:35,876 --> 01:06:40,781 WE PARTNER TO DO GENETIC COU 1429 01:06:40,781 --> 01:06:42,817 COUNSELING AS WELL AS RETURNING 1430 01:06:42,817 --> 01:06:44,652 OF THE RESULTS. 1431 01:06:44,652 --> 01:06:47,788 THE ENGAGEMENT PIECE AND 1432 01:06:47,788 --> 01:06:50,925 PHARMACO GENOMICS PARTICIPANTS 1433 01:06:50,925 --> 01:06:52,526 WILL GET A REPORT ON THESE. 1434 01:06:52,526 --> 01:06:56,697 HOWEVER IF SOMEONE HAS A 1435 01:06:56,697 --> 01:07:02,370 PATHOGENIC OR VARIANT IN THE 59 1436 01:07:02,370 --> 01:07:08,976 GENES IN DISEASE RISK REPORT RER 1437 01:07:08,976 --> 01:07:09,710 DOING RESPONSIBLE RETURN AND 1438 01:07:09,710 --> 01:07:11,178 GETTING PEOPLE INFORMATION THAT 1439 01:07:11,178 --> 01:07:15,916 MAY LEAD THEM TO PANIC OR 1440 01:07:15,916 --> 01:07:19,920 ANXIETY OR ANYTHING LIKE THAT. 1441 01:07:19,920 --> 01:07:23,691 WE HAVE A CLINICAL CONFIRMATION 1442 01:07:23,691 --> 01:07:27,528 TO BRING THAT TO THEIR DOCTOR 1443 01:07:27,528 --> 01:07:28,729 AND TAKE THE NEXT STEP. 1444 01:07:28,729 --> 01:07:30,564 A LITTLE BIT OF DATA SINCE I'M 1445 01:07:30,564 --> 01:07:32,199 HERE IN THIS PIECE. 1446 01:07:32,199 --> 01:07:35,536 I'LL SAVE THE REST OF THE DATA 1447 01:07:35,536 --> 01:07:36,037 FOR LATER. 1448 01:07:36,037 --> 01:07:39,206 SO FAR OVER 220 PARTICIPANTS 1449 01:07:39,206 --> 01:07:47,114 HAVE LOOKED AT THE -- 220,000 1450 01:07:47,114 --> 01:07:50,251 PARTICIPANTS LOOKED AT THE 1451 01:07:50,251 --> 01:07:52,653 REPORT AND TRAIT REPORT AND 1452 01:07:52,653 --> 01:07:54,622 HEALTH RELATED REPORTS WE 1453 01:07:54,622 --> 01:07:57,058 RETURNED BUT HAVE SEEN ALMOST 1454 01:07:57,058 --> 01:07:58,926 150,000 INDIVIDUALS LOOK AT 1455 01:07:58,926 --> 01:08:00,828 THEIR HEREDITARY DISEASE RISK 1456 01:08:00,828 --> 01:08:03,898 REPORT AND ALSO SEEING 3% HAVE A 1457 01:08:03,898 --> 01:08:09,804 PATHOGENIC OR LIKELY PATHOGENIC 1458 01:08:09,804 --> 01:08:12,373 VARIANT ON AVERAGE WHAT THE 1459 01:08:12,373 --> 01:08:13,808 LITERATURE SHOWS IS THE 1460 01:08:13,808 --> 01:08:15,242 PREVALENCE ACROSS THE UNITED 1461 01:08:15,242 --> 01:08:17,678 STATES AND HAVE ABOUT 142,000 1462 01:08:17,678 --> 01:08:19,914 PARTICIPANTS WHO HAVE SEEN THEIR 1463 01:08:19,914 --> 01:08:21,582 MEDICINE IN YOUR DNA REPORT. 1464 01:08:21,582 --> 01:08:23,884 AS YOU CAN IMAGINE, MANY MORE 1465 01:08:23,884 --> 01:08:25,486 PEOPLE WILL GET SOME SORT OF 1466 01:08:25,486 --> 01:08:27,088 RESULT FROM THIS MEANING THEY 1467 01:08:27,088 --> 01:08:30,091 ARE WILL HAVE A VARIANT THAT 1468 01:08:30,091 --> 01:08:39,533 IMPACTS HOW THEY MAY PROFESSION 1469 01:08:39,533 --> 01:08:41,135 PROCESS MEDICATION AND THE 1470 01:08:41,135 --> 01:08:42,670 HEREDITARY DISEASE RISK REPORT 1471 01:08:42,670 --> 01:08:45,372 AND ALLOW PEOPLE TO CALL A 1472 01:08:45,372 --> 01:08:47,007 GENETIC COUNSELOR AND MAKE AN 1473 01:08:47,007 --> 01:08:47,675 APPOINTMENT AND SAYING I HAVE 1474 01:08:47,675 --> 01:08:49,376 THIS VARIANT AND TAKING THIS 1475 01:08:49,376 --> 01:08:50,611 DRUG WHAT DOES IT THIS MEAN TO 1476 01:08:50,611 --> 01:08:52,179 GET MORE INFORMATION AND HAVE A 1477 01:08:52,179 --> 01:08:53,848 REAL CONVERSATION WITH SOMEONE 1478 01:08:53,848 --> 01:08:58,586 WHO UNDERSTANDS. 1479 01:08:58,586 --> 01:09:00,955 NOW WE'LL TALK ABOUT ACCESSING 1480 01:09:00,955 --> 01:09:02,389 DATA IN RESEARCH TOOLS. 1481 01:09:02,389 --> 01:09:03,591 I'LL GO A LITTLE FAST THROUGH 1482 01:09:03,591 --> 01:09:08,796 THIS TO SAVE TIME FOR 1483 01:09:08,796 --> 01:09:09,096 DISCUSSION. 1484 01:09:09,096 --> 01:09:11,599 I DO WANT TO SHOW EVERYONE WHAT 1485 01:09:11,599 --> 01:09:13,534 WE HAVE AND ENCOURAGE TO SHARE 1486 01:09:13,534 --> 01:09:14,668 RESOURCES WITH YOUR COLLEAGUES 1487 01:09:14,668 --> 01:09:18,305 AND STUDENTS AND MORE. 1488 01:09:18,305 --> 01:09:19,907 SO AGAIN BRINGING BACK THE CORE 1489 01:09:19,907 --> 01:09:20,207 VALUES. 1490 01:09:20,207 --> 01:09:22,109 WE WANT TO MAKE SURE DATA IS 1491 01:09:22,109 --> 01:09:23,711 GOING TO BE ACCESSIBLE FOR 1492 01:09:23,711 --> 01:09:25,780 RESEARCH PURPOSES, SECURITY AND 1493 01:09:25,780 --> 01:09:27,081 PRIVACY ARE REALLY IMPORTANT TO 1494 01:09:27,081 --> 01:09:29,683 US AND SOMETHING WE HOLD TRUE TO 1495 01:09:29,683 --> 01:09:31,152 AND THE PROGRAM WILL BE A 1496 01:09:31,152 --> 01:09:32,153 CATALYST FOR POSITIVE CHANGE IN 1497 01:09:32,153 --> 01:09:35,890 RESEARCH AND I THINK JUST BY 1498 01:09:35,890 --> 01:09:37,424 CREATING THE RESEARCH WORK BENCH 1499 01:09:37,424 --> 01:09:38,058 WE ALREADY HAVE BROKE THE MODEL 1500 01:09:38,058 --> 01:09:41,629 ON THAT. 1501 01:09:41,629 --> 01:09:45,065 SO WE HAVE THREE TIERS OF DATA. 1502 01:09:45,065 --> 01:09:47,067 I'LL BRIEFLY TALK ABOUT ALL OF 1503 01:09:47,067 --> 01:09:50,070 THEM. 1504 01:09:50,070 --> 01:09:51,038 THE FIRST I'LL TALK ABOUT AND 1505 01:09:51,038 --> 01:09:53,207 WALK YOU THROUGH EXAMPLES OF IS 1506 01:09:53,207 --> 01:09:55,009 PUBLIC TIER. 1507 01:09:55,009 --> 01:09:57,444 IT'S CALLED OUR DATA BROWSER. 1508 01:09:57,444 --> 01:09:59,680 AND YOU CAN ACTUALLY LOOK AT 1509 01:09:59,680 --> 01:10:03,350 DATA SNAPSHOTS, DO AN 1510 01:10:03,350 --> 01:10:04,652 INTERACTIVE SEARCH WITH OUR DATA 1511 01:10:04,652 --> 01:10:07,988 BROWSER, LOOK AT OUR SURVEYS AND 1512 01:10:07,988 --> 01:10:09,623 EVEN DOWNLOAD SURVEYS AS WELL AS 1513 01:10:09,623 --> 01:10:10,991 THE INFORMATION OF WHAT 1514 01:10:10,991 --> 01:10:13,627 VALIDATED SURVEYS DO THEY COME 1515 01:10:13,627 --> 01:10:15,229 FROM AND HOW DO WE CHOOSE THEM 1516 01:10:15,229 --> 01:10:17,198 AND WHAT ARE THE ANSWER TYPE TO 1517 01:10:17,198 --> 01:10:19,099 VALIDATE ACROSS STUDIES AND 1518 01:10:19,099 --> 01:10:20,568 ESPECIALLY IF OTHER STUDIES ARE 1519 01:10:20,568 --> 01:10:22,536 USING THE SAME QUESTIONS AND 1520 01:10:22,536 --> 01:10:23,904 THEN OUR RESEARCH PROJECT 1521 01:10:23,904 --> 01:10:25,940 DIRECTORY SO EVERYONE CAN SEE 1522 01:10:25,940 --> 01:10:27,875 WHAT'S GOING ON IN THE WORK 1523 01:10:27,875 --> 01:10:28,976 BENCH RIGHT NOW. 1524 01:10:28,976 --> 01:10:31,879 YOU'LL SEE WE HAVE OVER 12,000 1525 01:10:31,879 --> 01:10:32,746 RESEARCHERS USING THIS DATA 1526 01:10:32,746 --> 01:10:33,013 ALREADY. 1527 01:10:33,013 --> 01:10:34,515 EACH ONE OF THOSE HAS TO CREATE 1528 01:10:34,515 --> 01:10:35,850 A DESCRIPTION OF WHAT THEIR 1529 01:10:35,850 --> 01:10:37,751 DOING IN THE WORK BENCH AND YOU 1530 01:10:37,751 --> 01:10:41,021 CAN SEARCH ACROSS TO SEE WHAT'S 1531 01:10:41,021 --> 01:10:41,755 HAPPENING IN AREAS YOU MIGHT BE 1532 01:10:41,755 --> 01:10:44,291 INTERESTED IN. 1533 01:10:44,291 --> 01:10:49,029 AND THEN SORT OF OUR MORE I 1534 01:10:49,029 --> 01:10:50,931 GUESS I WOULD SAY CLOSED AREA IS 1535 01:10:50,931 --> 01:10:52,533 REALLY ONLY AVAILABLE TO THOSE 1536 01:10:52,533 --> 01:10:55,436 WHO ARE REGISTERED RESEARCHERS. 1537 01:10:55,436 --> 01:10:58,939 AND THAT'S WHERE OUR MORE 1538 01:10:58,939 --> 01:11:00,407 IDENTIFIABLE INFORMATION IS. 1539 01:11:00,407 --> 01:11:01,408 AND SO THAT'S WHERE YOU'LL FIND 1540 01:11:01,408 --> 01:11:04,511 OUR GENOMICS, OUR HEALTH AND 1541 01:11:04,511 --> 01:11:05,846 LIFESTYLE SURVEYS AND YOU'RE 1542 01:11:05,846 --> 01:11:11,385 ABLE TO DO SOME DYNAMIC ANALYSES 1543 01:11:11,385 --> 01:11:19,460 IN EITHER R PYTHON OR STUDIO OR 1544 01:11:19,460 --> 01:11:22,830 SAS I'LL TALK ABOUT IN A SECOND. 1545 01:11:22,830 --> 01:11:27,368 IN OUR WORK BENCH WE HAVE A 1546 01:11:27,368 --> 01:11:29,436 VERSION COMING OUT SOMETIME SOON 1547 01:11:29,436 --> 01:11:30,704 IN SEPTEMBER AND THIS WILL 1548 01:11:30,704 --> 01:11:32,339 INCREASE DRAMATICALLY. 1549 01:11:32,339 --> 01:11:37,478 SO YOU CAN SEE HOW MANY SURVEYS 1550 01:11:37,478 --> 01:11:39,880 COMPLETED ALMOST 2 MILLION AND 1551 01:11:39,880 --> 01:11:44,752 16,000 FITBIT RECORDS, 245,000 1552 01:11:44,752 --> 01:11:47,054 WHOLE GENOME SEQUENCES PHYSICAL 1553 01:11:47,054 --> 01:11:49,223 MEASUREMENTS FROM MANY PEOPLE, 1554 01:11:49,223 --> 01:11:50,190 287,000 E.H.R.s. 1555 01:11:50,190 --> 01:11:54,662 IT'S REALLY AN AMAZING BIG DATA 1556 01:11:54,662 --> 01:11:55,329 PLATFORM AND IT'S GOING TO KEEP 1557 01:11:55,329 --> 01:11:59,199 GROWING OVER TIME. 1558 01:11:59,199 --> 01:11:59,967 NOT JUST BECAUSE WE'RE ADDING 1559 01:11:59,967 --> 01:12:01,669 ADDITIONAL PARTICIPANTS TO THE 1560 01:12:01,669 --> 01:12:03,137 DATA BUT ALSO BECAUSE WE'RE 1561 01:12:03,137 --> 01:12:04,338 EXPANDING THE DATA TYPES AND 1562 01:12:04,338 --> 01:12:05,706 I'LL SHOW YOU A LITTLE BIT ABOUT 1563 01:12:05,706 --> 01:12:07,841 THAT IN A SECOND. 1564 01:12:07,841 --> 01:12:11,712 BUT WITH THIS RELEASE THAT CAME 1565 01:12:11,712 --> 01:12:15,516 OUT LAST YEAR WE FOUND VARIATION 1566 01:12:15,516 --> 01:12:19,553 AND MORE THAN 1 BILLION 1567 01:12:19,553 --> 01:12:27,828 LOCATIONS, WUN -- ONE-THIRD OF 1568 01:12:27,828 --> 01:12:31,932 THE HUMAN GENOME AND WE'RE 1569 01:12:31,932 --> 01:12:35,035 ADDING TO THE SCIENCE THAT'S OUT 1570 01:12:35,035 --> 01:12:36,103 THERE AS WELL AS ALLOWING THE 1571 01:12:36,103 --> 01:12:37,771 BROAD ACCESS WHICH IS REALLY 1572 01:12:37,771 --> 01:12:38,772 BREAKING THE HOLD IN HOW DATA 1573 01:12:38,772 --> 01:12:42,343 SHARING IS HAPPENING. 1574 01:12:42,343 --> 01:12:44,912 I WILL TELL YOU THAT EVEN THOUGH 1575 01:12:44,912 --> 01:12:47,548 THE ALL OF US LAUNCH OFFICIALLY 1576 01:12:47,548 --> 01:12:50,651 HAPPENED IN 2018, MANY OF OUR 1577 01:12:50,651 --> 01:12:52,653 DATA TYPES ARE LONGITUDE FLAL. 1578 01:12:52,653 --> 01:12:54,621 YOU CAN SEE WE HAVE E.H.R. DATA 1579 01:12:54,621 --> 01:12:58,492 THAT GOES BACK TO THE '90s. 1580 01:12:58,492 --> 01:13:05,733 SOME IN THE '80s AND FIT BIT 1581 01:13:05,733 --> 01:13:08,936 DATA AND THERE'S LONGITUDINAL 1582 01:13:08,936 --> 01:13:10,871 DATA IN OUR WORK BENCH AND TALK 1583 01:13:10,871 --> 01:13:12,673 ABOUT OUR EFFORTS TO GET DATA 1584 01:13:12,673 --> 01:13:14,742 OVER TIME FROM PARTICIPANTS 1585 01:13:14,742 --> 01:13:15,009 DIRECTLY. 1586 01:13:15,009 --> 01:13:17,711 I'LL DO A QUICK WALK THROUGH OF 1587 01:13:17,711 --> 01:13:18,212 OUR DATA BROWSER. 1588 01:13:18,212 --> 01:13:20,714 THIS IS PART OF THE PUBLIC 1589 01:13:20,714 --> 01:13:20,914 PIECE. 1590 01:13:20,914 --> 01:13:23,150 ANYONE CAN LOG ON TO RESEARCH 1591 01:13:23,150 --> 01:13:24,051 ALL OF US.org. 1592 01:13:24,051 --> 01:13:25,919 NO LOG ON IS REQUIRED. 1593 01:13:25,919 --> 01:13:27,588 YOU CAN SEE THINGS ACROSS ALL OF 1594 01:13:27,588 --> 01:13:29,356 OUR DIFFERENT DATA TYPES WE'RE 1595 01:13:29,356 --> 01:13:30,057 COLLECTING. 1596 01:13:30,057 --> 01:13:32,726 YOU CAN EVEN DO A KEY WORD 1597 01:13:32,726 --> 01:13:34,828 SEARCH AND SEARCH ACROSS THE 1598 01:13:34,828 --> 01:13:35,596 DATA TYPE. 1599 01:13:35,596 --> 01:13:38,298 SO I DID ONE OR ORAL CANCER AND 1600 01:13:38,298 --> 01:13:40,801 IT DID SEE THAT WE HAD TWO 1601 01:13:40,801 --> 01:13:41,835 MATCHING E.H.R. DOMAINS THAT 1602 01:13:41,835 --> 01:13:42,369 CAME UP. 1603 01:13:42,369 --> 01:13:45,706 AND SO WHEN I CLICKED ON THE 1604 01:13:45,706 --> 01:13:49,543 E.H.R. DOMAIN TAB, I SAW THAT WE 1605 01:13:49,543 --> 01:13:52,546 HAD 840 PARTICIPANTS WHO HAD A 1606 01:13:52,546 --> 01:13:55,382 DIAGNOSIS OF MALIGNANT TUMOR OF 1607 01:13:55,382 --> 01:13:57,451 THE ORAL CAVITY. 1608 01:13:57,451 --> 01:13:58,218 I GOT INTERESTED. 1609 01:13:58,218 --> 01:14:01,422 THAT'S A FAIRLY LARGE NUMBER. 1610 01:14:01,422 --> 01:14:03,624 THERE'S ACTUALLY THESE TOOLS ON 1611 01:14:03,624 --> 01:14:06,660 THE SIDE WHERE YOU CAN GRAPH 1612 01:14:06,660 --> 01:14:08,629 THIS BY BOTH SEX ASSIGNED AT 1613 01:14:08,629 --> 01:14:09,563 BIRTH, AGE AND SOURCES. 1614 01:14:09,563 --> 01:14:11,698 SO I CLICKED ON THAT AND YOU CAN 1615 01:14:11,698 --> 01:14:14,701 SEE THE AGE DISTRIBUTION FOR 1616 01:14:14,701 --> 01:14:15,436 THOSE 840 PARTICIPANTS THAT ARE 1617 01:14:15,436 --> 01:14:23,844 THERE. 1618 01:14:23,844 --> 01:14:25,746 THIS IS AGGREGATE ROLLED UP 1619 01:14:25,746 --> 01:14:28,182 DATA BUT IT GIVES YOU AN IDEA OF 1620 01:14:28,182 --> 01:14:30,284 WHAT IS IN OUR DATA SET TO START 1621 01:14:30,284 --> 01:14:35,322 TO FORMULATE, OKAY, I WANT TO DO 1622 01:14:35,322 --> 01:14:41,728 MUCH MORE OR MRAB WRITE A GRANT 1623 01:14:41,728 --> 01:14:43,430 AND UNDERSTAND WHAT'S IN THE 1624 01:14:43,430 --> 01:14:45,165 DATABASE BETTER BEFORE I PUT THE 1625 01:14:45,165 --> 01:14:46,100 GRANT IN. 1626 01:14:46,100 --> 01:14:46,800 IT'S A POWERFUL TOOL. 1627 01:14:46,800 --> 01:14:48,302 I USE IT FOR PRESENTATIONS AND 1628 01:14:48,302 --> 01:14:49,937 THINGS LIKE THAT BUT WAYS TO 1629 01:14:49,937 --> 01:14:52,506 SHOW THAT WHAT YOU'RE LOOKING 1630 01:14:52,506 --> 01:14:53,740 FOR IS ACTUALLY HERE 1631 01:14:53,740 --> 01:14:54,341 POTENTIALLY. 1632 01:14:54,341 --> 01:15:00,781 AND LOOKING AT THAT. 1633 01:15:00,781 --> 01:15:04,318 WITHIN OUR REGISTERED AREA WE 1634 01:15:04,318 --> 01:15:06,887 HAVE A CLOUD BASED PLATFORM. 1635 01:15:06,887 --> 01:15:08,255 WE HAVE SEVERAL DIFFERENT TOOLS 1636 01:15:08,255 --> 01:15:10,924 AVAILABLE. 1637 01:15:10,924 --> 01:15:14,428 I MENTIONED THAT YOU CAN USE 1638 01:15:14,428 --> 01:15:17,698 JUPITER NOTE BOOKS BUT HAVE TO 1639 01:15:17,698 --> 01:15:19,867 CODE IN PYTHON OR R WITH THE 1640 01:15:19,867 --> 01:15:20,467 FIRST STEPS. 1641 01:15:20,467 --> 01:15:23,537 WE HAVE NOW OPENED UP R STUDIO 1642 01:15:23,537 --> 01:15:25,873 AS WELL AS SAS. 1643 01:15:25,873 --> 01:15:28,442 WE BROUGHT SAS TO A CLOUD 1644 01:15:28,442 --> 01:15:30,811 COMPUTING PLATFORM WHICH IS HUGE 1645 01:15:30,811 --> 01:15:34,281 THINKING ABOUT THE NUMBER OF 1646 01:15:34,281 --> 01:15:36,517 EPIDEMIOLOGISTS AND USE SAS AS 1647 01:15:36,517 --> 01:15:39,553 AN ANALYSIS TOOL. 1648 01:15:39,553 --> 01:15:41,822 IT OPENS UP THE TOOL FOR WHO CAN 1649 01:15:41,822 --> 01:15:43,891 USE THE WORK BENCH IN A 1650 01:15:43,891 --> 01:15:45,225 MEANINGFUL WAY. 1651 01:15:45,225 --> 01:15:46,660 THERE ARE GRAPHICAL TOOLS TO 1652 01:15:46,660 --> 01:15:47,861 HELP YOU PICK THE DATA SET YOU 1653 01:15:47,861 --> 01:15:50,264 WANT TO WORK WITH. 1654 01:15:50,264 --> 01:15:51,498 THERE ARE POINT AND CLICK TOOLS 1655 01:15:51,498 --> 01:15:53,734 TO HELP BUILD YOUR RESEARCH 1656 01:15:53,734 --> 01:15:54,134 STUDY COLLECTION. 1657 01:15:54,134 --> 01:15:59,907 IT'S OPEN TO RESEARCHERS AT 1658 01:15:59,907 --> 01:16:03,076 ACADEMIC INSTITUTIONS AND OPENED 1659 01:16:03,076 --> 01:16:05,846 UP COMMERCIAL ACCESS AS WELL AS 1660 01:16:05,846 --> 01:16:06,847 INTERNATIONAL ACCESS. 1661 01:16:06,847 --> 01:16:09,449 SO WE'RE TRYING TO MAKE THIS AS 1662 01:16:09,449 --> 01:16:13,053 BROAD AS POSSIBLE AND TRYING TO 1663 01:16:13,053 --> 01:16:13,954 LEVEL THE PLAYING FIELD BY 1664 01:16:13,954 --> 01:16:15,889 PUTTING IT IN A CLOUD-BASED 1665 01:16:15,889 --> 01:16:17,558 PLATFORM SO EVERYONE HAS THE 1666 01:16:17,558 --> 01:16:18,559 SAME COMPUTE POWER AND STARTING 1667 01:16:18,559 --> 01:16:20,661 AT THE SAME LEVEL AND YOU DON'T 1668 01:16:20,661 --> 01:16:26,700 HAVE TO BE AT A TOP-TIER 1669 01:16:26,700 --> 01:16:31,138 UNIVERSITY WITH A LARGE 1670 01:16:31,138 --> 01:16:32,172 COMPUTING CENTER. 1671 01:16:32,172 --> 01:16:38,245 WE USED A DATA PASSPORT ACCESS 1672 01:16:38,245 --> 01:16:46,253 MODEL DINE AMMIC -- DYNAMICALLY 1673 01:16:46,253 --> 01:16:48,255 CHANGING HOW WE SHARE ACCESS. 1674 01:16:48,255 --> 01:16:51,124 ONCE YOU HAVE YOUR WORK SPACE 1675 01:16:51,124 --> 01:16:52,426 CREATE AND HAVE IT ON THE 1676 01:16:52,426 --> 01:16:54,995 DIRECTORY YOU CAN START TO PULL 1677 01:16:54,995 --> 01:16:55,896 IN ADDITIONAL DATA TYPES AND 1678 01:16:55,896 --> 01:16:57,331 DON'T HAVE TO ASK OR REAPPLY 1679 01:16:57,331 --> 01:16:59,032 EACH TIME WHEN YOU WANT TO PULL 1680 01:16:59,032 --> 01:17:03,337 IN THE DATA TYPE OR LOOK AT IT 1681 01:17:03,337 --> 01:17:03,737 DIFFERENTLY. 1682 01:17:03,737 --> 01:17:06,240 WE ALL KNOW THAT TYPICAL DATA 1683 01:17:06,240 --> 01:17:07,241 SHARING IS PUTTING IN A REQUEST 1684 01:17:07,241 --> 01:17:11,678 TO I -- A STEERING COMMITTEE 1685 01:17:11,678 --> 01:17:15,015 AND PUT IN A REQUEST AND FOR 1686 01:17:15,015 --> 01:17:16,850 SOMETHING ELSE YOU NEED AN 1687 01:17:16,850 --> 01:17:18,952 AMENDMENT OR ANOTHER 1688 01:17:18,952 --> 01:17:19,620 APPLICATION. 1689 01:17:19,620 --> 01:17:22,823 THAT HAS GONE AWAY WITH THE 1690 01:17:22,823 --> 01:17:25,726 RESEARCHER WORK BENCH. 1691 01:17:25,726 --> 01:17:27,894 ONCE PEOPLE HAVE BECOME AN 1692 01:17:27,894 --> 01:17:30,664 AUTHORIZED USER WITHIN THE 1693 01:17:30,664 --> 01:17:34,534 RESEARCHER WORK BENCH THEY HAVE 1694 01:17:34,534 --> 01:17:36,903 ACCESS TO ALL THESE AMAZING 1695 01:17:36,903 --> 01:17:38,639 THINGS WHICH IS GREAT. 1696 01:17:38,639 --> 01:17:41,008 THERE'S NO IRB APPROVAL 1697 01:17:41,008 --> 01:17:41,275 NECESSARY. 1698 01:17:41,275 --> 01:17:45,045 WE ACTUALLY HAVE THIS ALL AS 1699 01:17:45,045 --> 01:17:46,480 NON-HUMAN SUBJECTS RESEARCH 1700 01:17:46,480 --> 01:17:48,548 APPROVED BY OUR CENTRAL IRB. 1701 01:17:48,548 --> 01:17:51,018 SO THERE'S A LOT OF POSITIVES TO 1702 01:17:51,018 --> 01:17:54,888 THE PLATFORM HERE. 1703 01:17:54,888 --> 01:17:59,726 I MENTIONED THE DIVERSITY IN 1704 01:17:59,726 --> 01:18:01,728 GENETICS BUT SPECIFICALLY IN 1705 01:18:01,728 --> 01:18:03,563 RACE AND ETHNICITY WITH ONE 1706 01:18:03,563 --> 01:18:04,631 RELEASE AND IT WILL GET HIGHER 1707 01:18:04,631 --> 01:18:10,103 WITH THE NEXT RELEASE CHANGING 1708 01:18:10,103 --> 01:18:13,540 WHAT THE GENETIC DATA SETS OUT 1709 01:18:13,540 --> 01:18:16,376 THERE LOOK LIKE BASED ON THE 1710 01:18:16,376 --> 01:18:17,377 DIVERSITY OF OUR PARTICIPANTS 1711 01:18:17,377 --> 01:18:18,111 AND WHAT WE'RE ADDING TO THE 1712 01:18:18,111 --> 01:18:24,384 FIELD AS A WHOLE. 1713 01:18:24,384 --> 01:18:33,994 THIS IS WIDELY OPEN NOW. 1714 01:18:33,994 --> 01:18:35,228 THE MAJORITY OF OUR PEOPLE ARE 1715 01:18:35,228 --> 01:18:40,367 IN THE U.S. BUT WE'RE TRYING TO 1716 01:18:40,367 --> 01:18:49,609 EXPAND THAT. 1717 01:18:49,609 --> 01:18:52,112 AND OVER 600 PUBLICATIONS AND 1718 01:18:52,112 --> 01:18:55,816 GROWING EXPONENTIALLY. 1719 01:18:55,816 --> 01:18:58,285 REALLY ARE GROWING BUT ALSO 1720 01:18:58,285 --> 01:18:59,786 MAKING SURE THAT WE'RE REACHING 1721 01:18:59,786 --> 01:19:01,088 OUT TO FOLKS WHO TYPICALLY HAVE 1722 01:19:01,088 --> 01:19:03,724 NOT BEEN PART OF THIS TYPE OF 1723 01:19:03,724 --> 01:19:03,990 RESEARCH. 1724 01:19:03,990 --> 01:19:09,563 SO REALLY HAVE A BIG FOCUS ON 1725 01:19:09,563 --> 01:19:14,568 HBCUs AND HISPANIC 1726 01:19:14,568 --> 01:19:15,302 ORGANIZATIONS. 1727 01:19:15,302 --> 01:19:17,771 WE HAVE TRAINING TRAMMING TO HOW 1728 01:19:17,771 --> 01:19:19,406 TO CODE WITHIN OUR RESEARCHER 1729 01:19:19,406 --> 01:19:21,274 WORK AND USING A TRAIN THE 1730 01:19:21,274 --> 01:19:22,309 TRAINER MODEL AND TRAINING 1731 01:19:22,309 --> 01:19:24,411 PEOPLE AND HAVING THEM GO OUT 1732 01:19:24,411 --> 01:19:26,480 AND TRAIN PEOPLE AT THEIR 1733 01:19:26,480 --> 01:19:27,514 INSTITUTIONS INCLUDING STUDENTS 1734 01:19:27,514 --> 01:19:31,885 AND OTHERS THAT MIGHT REALLY 1735 01:19:31,885 --> 01:19:33,420 BENEFIT FROM ANALYSES WITHIN OUR 1736 01:19:33,420 --> 01:19:33,920 RESEARCHER WORK BENCH. 1737 01:19:33,920 --> 01:19:39,893 I MENTIONED THIS IS GROWING OVER 1738 01:19:39,893 --> 01:19:40,260 TIME. 1739 01:19:40,260 --> 01:19:41,128 WE'VE SEEN HIGH PROFILE PAPERS 1740 01:19:41,128 --> 01:19:42,129 FROM OUR DATA ALREADY. 1741 01:19:42,129 --> 01:19:44,865 I'LL GIVE YOU ACCESS TO ALL 1742 01:19:44,865 --> 01:19:46,366 THESE QR CODES TOWARD THE END SO 1743 01:19:46,366 --> 01:19:49,669 DON'T WORRY ABOUT CATCHING THEM 1744 01:19:49,669 --> 01:19:51,004 NOW. 1745 01:19:51,004 --> 01:19:53,140 I MENTIONED ALREADY WHAT 1746 01:19:53,140 --> 01:19:54,875 DIFFERENT SUPPORT WE HAVE. 1747 01:19:54,875 --> 01:19:57,210 THIS WILL COME BACK ON GETTING 1748 01:19:57,210 --> 01:19:58,578 ACCESS TO THE RESEARCHER WORK 1749 01:19:58,578 --> 01:19:58,979 BENCH. 1750 01:19:58,979 --> 01:20:01,848 THIS IS BOTTOM LINE HOW YOU GO 1751 01:20:01,848 --> 01:20:03,049 ABOUT DOING THAT. 1752 01:20:03,049 --> 01:20:05,118 SO I WANT TO SPEND TIME TALKING 1753 01:20:05,118 --> 01:20:06,887 ABOUT THE BENEFITS OF LEVERAGING 1754 01:20:06,887 --> 01:20:07,654 ALL OF US. 1755 01:20:07,654 --> 01:20:09,656 AND NOT JUST FOR THE DATA PART 1756 01:20:09,656 --> 01:20:11,458 THOUGH THE DATA PART IS AMAZING 1757 01:20:11,458 --> 01:20:12,526 AND I'LL GO THROUGH SOME 1758 01:20:12,526 --> 01:20:15,395 EXAMPLES OF THINGS DONE SO FAR. 1759 01:20:15,395 --> 01:20:23,770 BUT THE FACT WE HAVE RECONT 1760 01:20:23,770 --> 01:20:26,373 RECONTACTABLE BIO BANKS. 1761 01:20:26,373 --> 01:20:29,609 I'LL START START SAYING WE DID A 1762 01:20:29,609 --> 01:20:35,782 PROGRAM WHERE WE DID FUND THREE 1763 01:20:35,782 --> 01:20:39,886 FROM NIDCR. 1764 01:20:39,886 --> 01:20:44,191 WE AWARDED 25 SUPPLEMENTS AND 1765 01:20:44,191 --> 01:20:47,627 THEY HAD A SPACE TO TALK ABOUT 1766 01:20:47,627 --> 01:20:49,029 HERE'S WHAT WORKED FOR ME AND 1767 01:20:49,029 --> 01:20:50,797 THIS BILLING ISN'T WORKING FOR 1768 01:20:50,797 --> 01:20:52,065 ME AND PEOPLE RESPOND HERE'S HOW 1769 01:20:52,065 --> 01:20:53,600 I GOT OVER THAT. 1770 01:20:53,600 --> 01:20:59,773 IT'S A COMMUNITY OF HELPING EACH 1771 01:20:59,773 --> 01:21:10,283 OTHER BUT ALSO GIVING US FEED 1772 01:21:11,117 --> 01:21:11,384 BA 1773 01:21:11,384 --> 01:21:15,789 BACK -- FEEDBACK AND TRANSFORM 1774 01:21:15,789 --> 01:21:16,490 BEING DATA. 1775 01:21:16,490 --> 01:21:21,127 THINKING 7% TO 8% OF OUR 1776 01:21:21,127 --> 01:21:21,795 PARTICIPANTS HAVE ANY DENTAL 1777 01:21:21,795 --> 01:21:22,028 RECORDS. 1778 01:21:22,028 --> 01:21:25,799 HOW DO WE GO ABOUT CHANGING 1779 01:21:25,799 --> 01:21:25,999 THAT? 1780 01:21:25,999 --> 01:21:27,200 BRINGING PROBLEMS AND SHORTFALLS 1781 01:21:27,200 --> 01:21:28,802 OF OUR CURRENT PLATFORM TO US SO 1782 01:21:28,802 --> 01:21:36,443 WE CAN WORK ON ITERATING THAT 1783 01:21:36,443 --> 01:21:37,244 OVER TIME. 1784 01:21:37,244 --> 01:21:38,345 ONE OF THESE WILL BE PUBLISHING 1785 01:21:38,345 --> 01:21:39,813 SOON SO IT WILL BE OUT IN THE 1786 01:21:39,813 --> 01:21:41,114 RESEARCH FIELD. 1787 01:21:41,114 --> 01:21:41,982 HOPEFULLY THAT WILL CATALYZE 1788 01:21:41,982 --> 01:21:45,819 PEOPLE TO GET IN THERE AND START 1789 01:21:45,819 --> 01:21:47,787 USING THE RESEARCHER WORK AS 1790 01:21:47,787 --> 01:21:57,898 WELL. 1791 01:22:14,714 --> 01:22:17,784 PEOPLE CAN LOOK AT EPIGENETICS 1792 01:22:17,784 --> 01:22:20,353 AND FITBIT IS GOING WAY UP. 1793 01:22:20,353 --> 01:22:21,688 WE HAVE ALMOST 60,000 1794 01:22:21,688 --> 01:22:26,860 INDIVIDUALS WITH FITBIT DATA IN 1795 01:22:26,860 --> 01:22:28,695 OUR NEXT RELEASE AND IT'S THE 1796 01:22:28,695 --> 01:22:31,031 FIRST TIME WE'RE RELEASING DATA 1797 01:22:31,031 --> 01:22:34,568 FROM OUR SELF-IDENTIFIED ALASKAN 1798 01:22:34,568 --> 01:22:35,769 NATIVE, AMERICAN INDIAN 1799 01:22:35,769 --> 01:22:45,979 POPULATIONS. 1800 01:22:46,313 --> 01:22:48,248 AND USING ALL OF US RESEARCH 1801 01:22:48,248 --> 01:22:49,849 PROGRAM INFRASTRUCTURE AS A 1802 01:22:49,849 --> 01:22:53,486 WHOLE SO NOT JUST THE DATA BUT 1803 01:22:53,486 --> 01:22:54,120 THE INFRASTRUCTURE AS A WHOLE 1804 01:22:54,120 --> 01:22:59,926 CAN REDUCE TIME AND RESOURCES TO 1805 01:22:59,926 --> 01:23:01,695 LAUNCH STUDIES WITHOUT THE TONS 1806 01:23:01,695 --> 01:23:04,264 AND YEARS OF PLANNING AND COSTS 1807 01:23:04,264 --> 01:23:07,300 IT TAKES TO RECRUIT DIVERSE 1808 01:23:07,300 --> 01:23:08,602 INDIVIDUALS AND GET THIS GOING. 1809 01:23:08,602 --> 01:23:10,537 THIS IS A CONTINUALLY GROWING 1810 01:23:10,537 --> 01:23:10,971 RESEARCH RESOURCE. 1811 01:23:10,971 --> 01:23:13,673 SO AS I MENTIONED WE'RE 1812 01:23:13,673 --> 01:23:14,708 RELEASING DATA RATE AND 1813 01:23:14,708 --> 01:23:16,142 INCREASING THE DATA TYPES AND 1814 01:23:16,142 --> 01:23:17,777 THE AMOUNT OF DATA THAT IS GOING 1815 01:23:17,777 --> 01:23:20,447 INTO THIS. 1816 01:23:20,447 --> 01:23:22,248 WE'RE EXPANDING A 1817 01:23:22,248 --> 01:23:22,882 MULTIDIMENSIONAL DATA. 1818 01:23:22,882 --> 01:23:24,718 YOU CAN THINK ABOUT HOW WE CAN 1819 01:23:24,718 --> 01:23:26,152 MOVE BEYOND JUST THE ONE OR TWO 1820 01:23:26,152 --> 01:23:27,687 VARIABLES AT A TIME WE'RE 1821 01:23:27,687 --> 01:23:28,888 LOOKING AT AND START TO LOOK 1822 01:23:28,888 --> 01:23:32,292 MORE AT THE WHOLE PERSON. 1823 01:23:32,292 --> 01:23:33,460 WHAT ARE THEIR SOCIAL 1824 01:23:33,460 --> 01:23:34,928 DETERMINATES OF HEALTH LOOK 1825 01:23:34,928 --> 01:23:35,228 LIKE? 1826 01:23:35,228 --> 01:23:37,297 WHAT ARE THEIR ENVIRONMENTAL 1827 01:23:37,297 --> 01:23:39,299 EXPOSURES, WHAT DO THEIR 1828 01:23:39,299 --> 01:23:40,800 BIOLOGICS SAY AND HOW'S THIS FIT 1829 01:23:40,800 --> 01:23:42,068 TOGETHER TO TELL US WHAT'S GOING 1830 01:23:42,068 --> 01:23:43,169 ON WITH THE INDIVIDUAL ABOUT 1831 01:23:43,169 --> 01:23:44,871 THEIR ORAL AND DENTAL HEALTH? 1832 01:23:44,871 --> 01:23:47,207 AND FINALLY BEING ABLE TO ACCESS 1833 01:23:47,207 --> 01:23:49,209 NOVEL TOOLS AND DATA. 1834 01:23:49,209 --> 01:23:53,613 I MENTIONED THE SUPPLEMENT 1835 01:23:53,613 --> 01:23:53,847 PROGRAM. 1836 01:23:53,847 --> 01:23:55,448 WE ASKED INDIVIDUALS TO PUBLIC 1837 01:23:55,448 --> 01:23:58,051 THEIR WORK SPACES ONCE DONE AND 1838 01:23:58,051 --> 01:23:59,653 SHARE ANY TOOLS THEY CREATED OR 1839 01:23:59,653 --> 01:24:03,089 BROUGHT IN FROM OTHER PURPOSES 1840 01:24:03,089 --> 01:24:05,291 TO USE WITHIN THE DATA TO BE 1841 01:24:05,291 --> 01:24:10,230 LEVERAGED BY THE NEXT 1842 01:24:10,230 --> 01:24:11,431 INVESTIGATORS THAT COME AND ADD 1843 01:24:11,431 --> 01:24:13,533 TO IT AND THOSE WORK SPACES 1844 01:24:13,533 --> 01:24:14,901 CARRY OVER THROUGH OUR DIFFERENT 1845 01:24:14,901 --> 01:24:18,071 VERSIONS AND SO THEY CAN UPDATE 1846 01:24:18,071 --> 01:24:22,008 DATA AS THE VERSIONS CHANGE. 1847 01:24:22,008 --> 01:24:25,845 JUST A LITTLE BIT ABOUT THE 1848 01:24:25,845 --> 01:24:26,046 DATA. 1849 01:24:26,046 --> 01:24:30,350 WE HAVE FOUR PETABYTES DATA. 1850 01:24:30,350 --> 01:24:40,727 IT'S A BIG ENTERPRISE. 1851 01:24:42,996 --> 01:24:44,497 AND ACROSS INSTITUTIONS WOULD BE 1852 01:24:44,497 --> 01:24:47,701 BILLIONS BUT WE'RE ABLE TO DO IT 1853 01:24:47,701 --> 01:24:48,201 FOR 1.14. 1854 01:24:48,201 --> 01:24:49,769 THAT'S RESULTING IN A MAJOR 1855 01:24:49,769 --> 01:24:52,839 SAVING AND ALLOWING THE BROAD 1856 01:24:52,839 --> 01:24:57,277 ACCESS FOR MANY UNIVERSITIES AND 1857 01:24:57,277 --> 01:24:58,178 HOPEFULLY SOON CITIZEN 1858 01:24:58,178 --> 01:25:00,313 SCIENTISTS TO GET IN AND ASK THE 1859 01:25:00,313 --> 01:25:02,115 QUESTIONS THAT HADN'T BEEN ASKED 1860 01:25:02,115 --> 01:25:03,817 BEFORE BECAUSE THE SAME 1861 01:25:03,817 --> 01:25:05,485 INVESTIGATORS HAVE HAD ACCESS TO 1862 01:25:05,485 --> 01:25:09,622 THIS DATA FOR SO MANY YEARS 1863 01:25:09,622 --> 01:25:11,491 WE'LL START TO SEE INNOVATIVE 1864 01:25:11,491 --> 01:25:12,225 QUESTIONS BECAUSE THE PEOPLE 1865 01:25:12,225 --> 01:25:14,627 ASKING THE QUESTIONS HAVE A 1866 01:25:14,627 --> 01:25:15,328 DIFFERENT LIVED EXPERIENCE THAN 1867 01:25:15,328 --> 01:25:16,029 THOSE WHO ASKED THE QUESTIONS IN 1868 01:25:16,029 --> 01:25:19,332 THE PAST. 1869 01:25:19,332 --> 01:25:21,735 HERE'S JUST ONE QUICK EXAMPLE 1870 01:25:21,735 --> 01:25:27,474 ABOUT THE GENETIC BASES OF 1871 01:25:27,474 --> 01:25:31,111 HYPERTHYROIDISM. 1872 01:25:31,111 --> 01:25:34,614 NHGRI'S EMERGE PROGRAM SPENT 1873 01:25:34,614 --> 01:25:38,218 ALMOST THREE YEARS WITH A 1874 01:25:38,218 --> 01:25:40,720 RESOURCE INTENSIVE LOOKING FOR A 1875 01:25:40,720 --> 01:25:43,690 GWAS FOR HYPERTHYROIDISM AND AN 1876 01:25:43,690 --> 01:25:45,592 UNDERGRAD IN JOSH DENNY'S LAB 1877 01:25:45,592 --> 01:25:48,595 CAME IN OVER THE SUMMER IN 2023 1878 01:25:48,595 --> 01:25:49,996 AND REPLICATED THIS IN THE ALL 1879 01:25:49,996 --> 01:25:51,898 OF US PLATFORM. 1880 01:25:51,898 --> 01:25:58,738 HE WAS AN UNDERGRADUATE WHO 1881 01:25:58,738 --> 01:26:00,640 DIDN'T HAVE A TON OF KNOWLEDGE 1882 01:26:00,640 --> 01:26:02,776 IN CODING AND LEARNED IN WEEKS 1883 01:26:02,776 --> 01:26:05,178 AND THE CASES AND CONTROLS 1884 01:26:05,178 --> 01:26:06,913 BETWEEN THE TWO ARE FASTLY 1885 01:26:06,913 --> 01:26:07,147 HIGHER. 1886 01:26:07,147 --> 01:26:17,624 AND WE SAW MORE OF A SIGNAL. 1887 01:26:17,624 --> 01:26:18,925 IT'S A GOOD WAY TO THINK OF 1888 01:26:18,925 --> 01:26:20,693 WHAT WE'VE DONE IN THE PAST AND 1889 01:26:20,693 --> 01:26:21,895 BUILD UPON THAT BY BRINGING IN 1890 01:26:21,895 --> 01:26:25,265 THE DATA SET. 1891 01:26:25,265 --> 01:26:26,933 I ALSO WANT TO MENTION THAT WE 1892 01:26:26,933 --> 01:26:29,869 RECENTLY FUNDED A CENTER FOR 1893 01:26:29,869 --> 01:26:31,104 LINKAGE AND ACQUISITION OF DATA. 1894 01:26:31,104 --> 01:26:34,407 THIS IS GOING TO HELP US TO LINK 1895 01:26:34,407 --> 01:26:36,209 TO AVAILABLE DATA SOURCES 1896 01:26:36,209 --> 01:26:37,811 INCLUDING MORTALITY DATA AND 1897 01:26:37,811 --> 01:26:40,346 CLAIMS DATA AND GEOCODING DATA, 1898 01:26:40,346 --> 01:26:41,347 ENVIRONMENTAL DATA AND OTHER 1899 01:26:41,347 --> 01:26:43,583 SOURCES FOR ELECTRONIC HEALTH 1900 01:26:43,583 --> 01:26:46,152 RECORDS AND HAVE BEEN TALKING 1901 01:26:46,152 --> 01:26:47,353 WITH JENNIFER AND OTHER 1902 01:26:47,353 --> 01:26:52,125 LEADERSHIP HOW WE LINK TO DENTAL 1903 01:26:52,125 --> 01:26:53,326 RECORDS AND THERE ARE A LOT OF 1904 01:26:53,326 --> 01:26:55,061 COLLABORATORS WE SHOULD BE 1905 01:26:55,061 --> 01:26:57,263 TALKING TO ABOUT HOW DO WE GET 1906 01:26:57,263 --> 01:26:58,131 ADDITIONAL HEALTH INFORMATION 1907 01:26:58,131 --> 01:27:00,733 BEYOND WHAT OUR CURRENT THINKING 1908 01:27:00,733 --> 01:27:01,467 IS. 1909 01:27:01,467 --> 01:27:02,802 I'M EXCITED TO POTENTIALLY HAVE 1910 01:27:02,802 --> 01:27:03,536 THIS LINKAGE FOR DENTAL RECORDS 1911 01:27:03,536 --> 01:27:11,911 COMING SOON. 1912 01:27:11,911 --> 01:27:14,848 AND THIS MAY BE A SURPRISE TO 1913 01:27:14,848 --> 01:27:16,149 COLLEAGUES WE'RE DOING A 1914 01:27:16,149 --> 01:27:19,085 REASSESSMENT OF THE COHORT IN Q1 1915 01:27:19,085 --> 01:27:22,689 OF 2025 AND INCLUDING ORAL AND 1916 01:27:22,689 --> 01:27:27,594 DENTAL DATA IN THAT 1917 01:27:27,594 --> 01:27:29,395 QUESTIONNAIRE. 1918 01:27:29,395 --> 01:27:30,830 WE HAVE FOUR QUESTIONS IN NHANES 1919 01:27:30,830 --> 01:27:32,432 INCLUDING THE LAST VISIT TO A 1920 01:27:32,432 --> 01:27:35,735 DENTIST AND THE MAIN REASON AND 1921 01:27:35,735 --> 01:27:37,203 WERE YOU ABLE TO GET ACCESS TO 1922 01:27:37,203 --> 01:27:38,504 DENTAL CARE AND THE REASONS WHY 1923 01:27:38,504 --> 01:27:40,640 YOU COULD NOT GET DENTAL CARE. 1924 01:27:40,640 --> 01:27:42,008 THOSE ARE IN NHANES AND WE HAVE 1925 01:27:42,008 --> 01:27:43,877 A PERSONAL AND FAMILY HEALTH 1926 01:27:43,877 --> 01:27:46,846 HISTORY MODULE AND INCLUDED ORAL 1927 01:27:46,846 --> 01:27:49,749 AND DENTAL HEALTH CONDITIONS IN 1928 01:27:49,749 --> 01:27:51,751 THAT MODULE AS WELL AND 1929 01:27:51,751 --> 01:27:52,085 REASSESSMENT. 1930 01:27:52,085 --> 01:27:53,419 IT'S A SELECT ALL THAT APPLY AND 1931 01:27:53,419 --> 01:27:55,455 FOR THE FAMILY HEALTH HISTORY, 1932 01:27:55,455 --> 01:27:57,523 IF YOU SELECT ONE OF THESE THEN 1933 01:27:57,523 --> 01:27:59,893 YOU SORT OF SAY WHO IN YOUR 1934 01:27:59,893 --> 01:28:03,496 FAMILY HAS IT AND GO A LITTLE 1935 01:28:03,496 --> 01:28:04,797 BIT FURTHER INTO THAT. 1936 01:28:04,797 --> 01:28:06,599 I'M EXCITED ABOUT THE 1937 01:28:06,599 --> 01:28:07,867 PARTICIPANT PROVIDED INFORMATION 1938 01:28:07,867 --> 01:28:09,235 BEING THERE TOO NOT ONLY DO YOU 1939 01:28:09,235 --> 01:28:11,204 GET THE E.H.R. FROM THE DENTAL 1940 01:28:11,204 --> 01:28:15,875 RECORD AND ALSO GET THE 1941 01:28:15,875 --> 01:28:19,913 PARTICIPANT'S EXPERIENCE WITH 1942 01:28:19,913 --> 01:28:30,456 THEIR UNDERSTANDING WE HAVE FIVE 1943 01:28:33,426 --> 01:28:34,827 SITE ENROLLING 0 TO 4. 1944 01:28:34,827 --> 01:28:36,763 IT WOULD BE A GREAT PLACE TO 1945 01:28:36,763 --> 01:28:43,770 ALSO GET DENTAL RECORDS FOR. 1946 01:28:43,770 --> 01:28:44,938 AND DISPARITIES IN WHO IS ABLE 1947 01:28:44,938 --> 01:28:46,172 TO GET CARE AND WHO IS NOT ABLE 1948 01:28:46,172 --> 01:28:56,382 TO GET CARE. 1949 01:28:59,752 --> 01:29:03,556 AND ANCILLARY STUDIES WITHIN THE 1950 01:29:03,556 --> 01:29:05,625 ALL OF US RESEARCH STUDIES. 1951 01:29:05,625 --> 01:29:07,894 I'VE TALKED ABOUT THE DATA 1952 01:29:07,894 --> 01:29:09,829 THAT'S GOING TO BE AVAILABLE OR 1953 01:29:09,829 --> 01:29:10,797 THAT IS AVAILABLE AND WHAT'S 1954 01:29:10,797 --> 01:29:12,598 COMING BUT WE'RE ENGAGING WITH 1955 01:29:12,598 --> 01:29:19,872 OUR INSTITUTES AND CENTERS TO DO 1956 01:29:19,872 --> 01:29:22,408 BIO SPECIMEN USE USING SPECIMENS 1957 01:29:22,408 --> 01:29:23,743 SELECTED TO DO RECONTACT FOR 1958 01:29:23,743 --> 01:29:26,579 PARTICIPANTS TO DO SURVEYS OR 1959 01:29:26,579 --> 01:29:29,916 SEND OUT NEW WEARABLES AND ASK 1960 01:29:29,916 --> 01:29:34,921 THEM TO USE IT AND HAVE A STUDY 1961 01:29:34,921 --> 01:29:35,922 CALLED NUTRITION FOR PRECISION 1962 01:29:35,922 --> 01:29:38,391 HEALTH FEATURED ON GOOD MORNING 1963 01:29:38,391 --> 01:29:41,928 AMERICA MAY 3 AND THIS STORY ON 1964 01:29:41,928 --> 01:29:45,365 GOOD MORNING AMERICA RESULTED IN 1965 01:29:45,365 --> 01:29:48,368 OVER 4 40 NEW CONCEPT FOR ALL OF 1966 01:29:48,368 --> 01:29:56,809 US THROUGH A WEEKEND. 1967 01:29:56,809 --> 01:29:59,712 AND THESE ANCILLARY STUDIES 1968 01:29:59,712 --> 01:30:03,783 ALLOW US TO DIVE DEEP IN ON 1969 01:30:03,783 --> 01:30:05,918 SUBJECTS WE ONLY TOUCHED THE 1970 01:30:05,918 --> 01:30:07,887 SURFACE OF LIKE THE ORAL HEALTH 1971 01:30:07,887 --> 01:30:15,061 QUESTIONS YOU SAW. 1972 01:30:15,061 --> 01:30:18,164 WE'RE PARTNERING TO DO ANCILLARY 1973 01:30:18,164 --> 01:30:19,899 STUDIES WHILE REWE'RE LAYING THE 1974 01:30:19,899 --> 01:30:20,867 GROUND WORK. 1975 01:30:20,867 --> 01:30:27,874 WOE WANT TO OPEN UP ACCESS FOR 1976 01:30:27,874 --> 01:30:30,743 EXTRAMURAL OR NIH INTRAMURAL 1977 01:30:30,743 --> 01:30:31,411 INVESTIGATORS TO COME IN THE 1978 01:30:31,411 --> 01:30:33,079 PROGRAM BUT WANT TO MAKE SURE WE 1979 01:30:33,079 --> 01:30:35,448 HAVE POLICIES IN PLACE, A WAY TO 1980 01:30:35,448 --> 01:30:37,984 SUBMIT FORMS AND MODALITIES AND 1981 01:30:37,984 --> 01:30:39,752 WANT TO BE TRANSPARENT ABOUT OUR 1982 01:30:39,752 --> 01:30:44,557 REVIEW CRITERIA IN ACCEPTING 1983 01:30:44,557 --> 01:30:46,592 APPLICATIONS. 1984 01:30:46,592 --> 01:30:48,261 WHILE WORKING WITH CENTERS WE'RE 1985 01:30:48,261 --> 01:30:51,397 LAYING GROUND WORK AND MAKING 1986 01:30:51,397 --> 01:30:57,970 PROGRESS THERE TO OPEN UP IN 1987 01:30:57,970 --> 01:31:03,409 2026. 1988 01:31:03,409 --> 01:31:04,911 TO INTEGRATE ORAL AND GENERAL 1989 01:31:04,911 --> 01:31:05,144 HEALTH. 1990 01:31:05,144 --> 01:31:09,282 I MENTIONED ALL OF US 1991 01:31:09,282 --> 01:31:11,617 LONGITUDINAL HEALTH RECORDS DATA 1992 01:31:11,617 --> 01:31:14,987 AND GENOMICS HEALTH DATA AND ONE 1993 01:31:14,987 --> 01:31:18,558 WAY TO LOOK AT HEALTHY COHORTS 1994 01:31:18,558 --> 01:31:21,127 ACROSS DISEASE STATES, WE KNOW 1995 01:31:21,127 --> 01:31:22,862 IT'S LACKING IN ORAL HEALTH DATA 1996 01:31:22,862 --> 01:31:24,931 BUT I HOPE THAT GETTING SOME OF 1997 01:31:24,931 --> 01:31:27,433 THESE LINKAGES IN PLACE AND AS 1998 01:31:27,433 --> 01:31:29,302 WE START TO BRING IN SURVEY 1999 01:31:29,302 --> 01:31:30,503 QUESTIONS AND OTHER THINGS WE 2000 01:31:30,503 --> 01:31:34,340 CAN BEEF UP WHAT CAN BE DONE 2001 01:31:34,340 --> 01:31:34,540 THERE. 2002 01:31:34,540 --> 01:31:35,908 WE ALREADY HEARD ABOUT PRECISION 2003 01:31:35,908 --> 01:31:37,210 DENTAL MEDICINE. 2004 01:31:37,210 --> 01:31:41,848 HOW DO WE LOOK AT EARLY DISEASE 2005 01:31:41,848 --> 01:31:42,915 DETECTION, THINGS THAT CAN 2006 01:31:42,915 --> 01:31:45,985 CONTRIBUTE TO DISPARITIES AND 2007 01:31:45,985 --> 01:31:46,252 TREATMENT. 2008 01:31:46,252 --> 01:31:47,386 TRANSLATION AND IMPLEMENTATION. 2009 01:31:47,386 --> 01:31:49,188 CONNECTING THE DENTAL RECORDS 2010 01:31:49,188 --> 01:31:50,857 WITHIN OUR ECO SYSTEM I THINK IS 2011 01:31:50,857 --> 01:31:52,692 GOING TO BE KEY TO THAT AND 2012 01:31:52,692 --> 01:31:53,659 ACCELERATING DISCOVERY AND 2013 01:31:53,659 --> 01:31:56,529 VALIDATION OF RESEARCH FINDINGS 2014 01:31:56,529 --> 01:31:57,830 THAT HAVE ALREADY HAPPENED AND 2015 01:31:57,830 --> 01:32:01,134 THAT VALIDATION CAN SERVE TO 2016 01:32:01,134 --> 01:32:02,301 PUSH THINGS TO MORE CLINICAL 2017 01:32:02,301 --> 01:32:03,636 PRACTICE AND NOT HAVE TO BE 2018 01:32:03,636 --> 01:32:04,871 RESEARCH BASED. 2019 01:32:04,871 --> 01:32:06,372 MAKING SURE WE'RE SUPPORTING OUR 2020 01:32:06,372 --> 01:32:07,874 DIVERSE RESEARCH PIPELINE. 2021 01:32:07,874 --> 01:32:11,878 I MENTIONED OUR EFFORTS AROUND 2022 01:32:11,878 --> 01:32:14,614 HBCUs AND HISPANIC INSTITUTIONS 2023 01:32:14,614 --> 01:32:16,516 IS OF INTEREST TO NIDCR AND 2024 01:32:16,516 --> 01:32:19,152 FINALLY PART, THE AND 2025 01:32:19,152 --> 01:32:20,653 COLLABORATE BEING ACROSS NIDCR 2026 01:32:20,653 --> 01:32:23,890 AND WITH ALL OF THE GRANTEES AND 2027 01:32:23,890 --> 01:32:24,690 INVESTIGATORS CAN HELP ADVANCE 2028 01:32:24,690 --> 01:32:26,492 OUR UNDERSTANDING OF THE 2029 01:32:26,492 --> 01:32:26,893 POPULATION LEVEL. 2030 01:32:26,893 --> 01:32:29,762 SO WITH THAT, I WOULD LOVE TO 2031 01:32:29,762 --> 01:32:31,030 CLOSE AND TAKE QUESTIONS OR HAVE 2032 01:32:31,030 --> 01:32:35,234 DISCUSSION AROUND THIS. 2033 01:32:35,234 --> 01:32:35,902 THANK YOU. 2034 01:32:35,902 --> 01:32:37,603 >> THANK YOU VERY MUCH, 2035 01:32:37,603 --> 01:32:38,070 DR. SCHULLY. 2036 01:32:38,070 --> 01:32:39,872 THAT WAS TERRIFIC. 2037 01:32:39,872 --> 01:32:48,581 VERY COMPREHENSIVE. 2038 01:32:48,581 --> 01:32:50,917 I'D LIKE TO OPEN QUESTIONS IN 2039 01:32:50,917 --> 01:32:53,886 RESPONSE TO DR. WEBB-CYRIAQUE'S 2040 01:32:53,886 --> 01:33:04,397 PRESENTATION OR DR. SCHULLY'S. 2041 01:33:15,942 --> 01:33:19,879 >> I'M WONDERING IF YOU COULD 2042 01:33:19,879 --> 01:33:23,883 TALK ABOUT ANY STRATEGIES TO GO 2043 01:33:23,883 --> 01:33:26,352 AFTER THE VULNERABLE POPULATIONS 2044 01:33:26,352 --> 01:33:28,921 PARTICULARLY SINCE WE KNOW SO 2045 01:33:28,921 --> 01:33:30,022 MUCH ABOUT THE SOCIAL 2046 01:33:30,022 --> 01:33:30,690 DETERMINATES OF HEALTH HAVING 2047 01:33:30,690 --> 01:33:34,560 SUCH AN IMPACT ON ALL FACETS OF 2048 01:33:34,560 --> 01:33:38,664 HEALTH AND THE POPULATIONS ARE 2049 01:33:38,664 --> 01:33:39,432 NOTORIOUSLY DIFFICULT TO 2050 01:33:39,432 --> 01:33:41,234 FOLLOW-UP WITH AND DISAPPEAR AND 2051 01:33:41,234 --> 01:33:41,901 NOT COMPLIANT WITH THEIR 2052 01:33:41,901 --> 01:33:44,237 MEDICATIONS. 2053 01:33:44,237 --> 01:33:48,040 I KNOW YOU'RE NOT THERE YET BUT 2054 01:33:48,040 --> 01:33:49,742 WHAT KIND OF STRATEGIES I'M SURE 2055 01:33:49,742 --> 01:33:50,977 YOU THOUGHT ABOUT TO CAPTURE 2056 01:33:50,977 --> 01:33:56,382 THIS POPULATION THAT'S SO 2057 01:33:56,382 --> 01:33:57,183 IMPORTANT. 2058 01:33:57,183 --> 01:34:02,054 >> I WILL SAY WE HAVE 2059 01:34:02,054 --> 01:34:03,155 ORGANIZATIONS THAT HELP US 2060 01:34:03,155 --> 01:34:04,657 THROUGH THIS AND I DON'T KNOW 2061 01:34:04,657 --> 01:34:05,691 THESE POPULATIONS ARE 2062 01:34:05,691 --> 01:34:06,993 NECESSARILY HARD TO FIND. 2063 01:34:06,993 --> 01:34:09,195 I THINK THEY JUST HAVE OTHER 2064 01:34:09,195 --> 01:34:09,495 PRIORITIES. 2065 01:34:09,495 --> 01:34:10,329 ONE OF THE THINGS WE'VE BEEN 2066 01:34:10,329 --> 01:34:12,498 DOING IS REALLY TRYING TO MEET 2067 01:34:12,498 --> 01:34:13,699 THEM WHERE THEY ARE. 2068 01:34:13,699 --> 01:34:16,102 HOW DO WE PARTNER WITH THEIR 2069 01:34:16,102 --> 01:34:17,436 CHURCHES THEY'RE NORMALLY 2070 01:34:17,436 --> 01:34:17,937 ATTENDING. 2071 01:34:17,937 --> 01:34:21,240 THE PLACES THEY GIVE RESOURCES 2072 01:34:21,240 --> 01:34:23,909 AND THERE'S SOME EXAMPLES OF 2073 01:34:23,909 --> 01:34:27,346 THINGS WE'RE DOING IN THE SOUTH 2074 01:34:27,346 --> 01:34:28,381 WHERE WE ACTUALLY ARE COMMUNITY 2075 01:34:28,381 --> 01:34:31,884 PARTNERS ARE GOING TO PLACES 2076 01:34:31,884 --> 01:34:34,220 THAT ON THURSDAY NIGHTS THERE 2077 01:34:34,220 --> 01:34:35,588 ARE FOOD BANK AND ALSO THEIR 2078 01:34:35,588 --> 01:34:39,892 CHURCH AND WHERE THEY MEET AS A 2079 01:34:39,892 --> 01:34:42,028 COMMUNITY BECAUSE THERE'S A 2080 01:34:42,028 --> 01:34:44,430 LARGE SPANISH SPEAKING 2081 01:34:44,430 --> 01:34:47,233 POPULATION AND HOW DO WE 2082 01:34:47,233 --> 01:34:47,933 INTEGRATE TO WHERE WE ARE? 2083 01:34:47,933 --> 01:34:51,437 WHEN YOU HAVE A MILLION THINGS 2084 01:34:51,437 --> 01:34:52,805 GOING ON SOMETIMES THE RESEARCH 2085 01:34:52,805 --> 01:34:53,939 ISN'T YOUR PRIORITY OR GETTING 2086 01:34:53,939 --> 01:34:55,775 THE MEDICATION MAY BE DIFFICULT 2087 01:34:55,775 --> 01:34:56,509 BECAUSE YOU LOST INSURANCE OR 2088 01:34:56,509 --> 01:34:59,412 CAN'T GET TO THE DOCTOR. 2089 01:34:59,412 --> 01:35:00,046 MEETING PEOPLE WHERE THEY ARE 2090 01:35:00,046 --> 01:35:08,421 AND AOUR COMMUNITY PARTNERS HAVE 2091 01:35:08,421 --> 01:35:09,221 HELPED US THROUGH THE CHANGE. 2092 01:35:09,221 --> 01:35:10,356 IT'S NOT THE POPULATIONS ARE 2093 01:35:10,356 --> 01:35:12,458 HARD TO REACH YOU JUST HAVE TO 2094 01:35:12,458 --> 01:35:13,959 THINK OF A DIFFERENT WAY TO 2095 01:35:13,959 --> 01:35:14,827 REACH THEM. 2096 01:35:14,827 --> 01:35:19,065 >> THANK YOU FOR SHARING YOUR 2097 01:35:19,065 --> 01:35:20,232 SLIDES TOO TO DIGEST THE 2098 01:35:20,232 --> 01:35:20,733 MATERIAL AND LOOK IT UP. 2099 01:35:20,733 --> 01:35:26,372 THANK YOU. 2100 01:35:26,372 --> 01:35:29,108 >> I JUST HAVE A QUESTION AND 2101 01:35:29,108 --> 01:35:33,646 COMMENT AND RELATED TO A QUERY. 2102 01:35:33,646 --> 01:35:34,980 FIRST, SINCE ORAL HEALTH IS 2103 01:35:34,980 --> 01:35:37,516 CENTRAL TO OVER ALL HEALTH IT'S 2104 01:35:37,516 --> 01:35:38,718 SO IMPORTANT ORAL HEALTH 2105 01:35:38,718 --> 01:35:40,753 QUESTIONS WILL BE A PART OF THE 2106 01:35:40,753 --> 01:35:41,721 CORE ALL OF US SURVEY. 2107 01:35:41,721 --> 01:35:46,025 WE APPLAUD YOU ON THAT. 2108 01:35:46,025 --> 01:35:49,729 IT'S SO CRITICAL. 2109 01:35:49,729 --> 01:35:51,664 GOOD NEWS, DR. WEINTRAUB SHARED 2110 01:35:51,664 --> 01:35:58,003 WITH US HER PUBLICATION WAS 2111 01:35:58,003 --> 01:36:00,506 ACCEPTED FOR LOOKING AT ALL OF 2112 01:36:00,506 --> 01:36:05,945 US DATA, DENTAL DATA FOR OLDER 2113 01:36:05,945 --> 01:36:09,749 ADULTS. 2114 01:36:09,749 --> 01:36:11,350 EXCELLENT NEWS THERE AND I THINK 2115 01:36:11,350 --> 01:36:13,219 THERE'S OPPORTUNITIES FOR MORE 2116 01:36:13,219 --> 01:36:14,754 COLLABORATION AS WE LOOK AT THE 2117 01:36:14,754 --> 01:36:17,056 ADAPT PROGRAM THAT I MENTIONED 2118 01:36:17,056 --> 01:36:19,992 EARLIER ON AND THAT INITIATIVE 2119 01:36:19,992 --> 01:36:26,132 IS FOCUSES ON COMMUNITY-BASED 2120 01:36:26,132 --> 01:36:27,133 PARTICIPATORY RESEARCH AND DATA 2121 01:36:27,133 --> 01:36:29,935 TOWARDS DIMINISHING ORAL HEALTH 2122 01:36:29,935 --> 01:36:30,236 DISPARITIES. 2123 01:36:30,236 --> 01:36:31,404 I THINK BEING CREATIVE ACROSS 2124 01:36:31,404 --> 01:36:36,709 HOW WE ENGAGE THE COMMUNITY AND 2125 01:36:36,709 --> 01:36:39,779 LEVERAGING THE DATA RESOURCES 2126 01:36:39,779 --> 01:36:44,283 MAY HELP US GET TO WHAT YOUR 2127 01:36:44,283 --> 01:36:47,887 SAYING, PAUL, TO WHAT YOU'RE 2128 01:36:47,887 --> 01:36:50,890 ASKING. 2129 01:36:50,890 --> 01:36:53,359 >> FROM AN NIH STANDPOINT IT MAY 2130 01:36:53,359 --> 01:36:55,327 BE TOO MANY PLACE TRYING TO 2131 01:36:55,327 --> 01:37:00,599 REACH OUT TO THE SAME PEOPLE. 2132 01:37:00,599 --> 01:37:07,706 HOW DO WE COME TOGETHER TO NOT 2133 01:37:07,706 --> 01:37:08,574 FATIGUE PEOPLE IN BEING ASKED TO 2134 01:37:08,574 --> 01:37:09,842 JOIN A STUDY. 2135 01:37:09,842 --> 01:37:13,446 THERE'S EFFORTS WE CAN DO TO 2136 01:37:13,446 --> 01:37:14,046 COORDINATE THAT INTERNALLY AS 2137 01:37:14,046 --> 01:37:24,156 WELL. 2138 01:37:29,728 --> 01:37:32,364 >> WE WOULD LOVE TO HAVE MORE 2139 01:37:32,364 --> 01:37:33,666 ENGAGEMENT FROM COMMUNITY 2140 01:37:33,666 --> 01:37:35,234 LEADERS ESPECIALLY IN PLACES 2141 01:37:35,234 --> 01:37:36,435 WHERE WE DON'T HAVE A LOT OF 2142 01:37:36,435 --> 01:37:37,102 RESEARCH HAPPENING. 2143 01:37:37,102 --> 01:37:41,941 OUR DIRECTOR OF ENGAGEMENT, 2144 01:37:41,941 --> 01:37:43,943 DR. CARRINE WATSON IS AMAZING 2145 01:37:43,943 --> 01:37:46,312 AND OUR GURU IN THIS. 2146 01:37:46,312 --> 01:37:49,782 I WOULD BE HAPPY TO FACILITATE A 2147 01:37:49,782 --> 01:37:50,850 CONVERSATION AROUND HOW MORE 2148 01:37:50,850 --> 01:37:51,650 COMMUNITY LEADERS CAN GET 2149 01:37:51,650 --> 01:37:55,421 INVOLVED IN ALL OF US AS WE 2150 01:37:55,421 --> 01:37:58,057 ARE -- THAT'S HOW WE ARE 2151 01:37:58,057 --> 01:37:59,425 REACHING THESE POPULATIONS THAT 2152 01:37:59,425 --> 01:38:03,896 HAVE HISTORICALLY NOT BEEN PART 2153 01:38:03,896 --> 01:38:05,664 OF RESEARCH TO DATE. 2154 01:38:05,664 --> 01:38:05,898 GREAT. 2155 01:38:05,898 --> 01:38:15,107 ARE THERE QUESTIONS? 2156 01:38:15,107 --> 01:38:18,511 >> YES, I'M SORRY, I COULDN'T 2157 01:38:18,511 --> 01:38:19,612 FIND THE AUDIO BUTTON. 2158 01:38:19,612 --> 01:38:22,081 I'M A PARTICIPANT IN ALL OF US. 2159 01:38:22,081 --> 01:38:23,883 I LOOK FORWARD TO SEEING 2160 01:38:23,883 --> 01:38:28,354 INFORMATION FROM Y'ALL. 2161 01:38:28,354 --> 01:38:33,559 I CAN'T REMEMBER WHEN I FIRST 2162 01:38:33,559 --> 01:38:35,861 START 2163 01:38:35,861 --> 01:38:38,197 STARTED FILLING OUT THE FORMS 2164 01:38:38,197 --> 01:38:39,865 WERE THERE INFORMING TO 2165 01:38:39,865 --> 01:38:41,834 UNDERSTAND TRAUMA INFORMED CARE? 2166 01:38:41,834 --> 01:38:47,473 FOR EXAMPLE, ADVERSE CHILDHOOD 2167 01:38:47,473 --> 01:38:47,873 EXPERIENCES? 2168 01:38:47,873 --> 01:38:51,176 >> WE HAVE BASIC QUESTIONS ON 2169 01:38:51,176 --> 01:38:53,145 OUR MENTAL HEALTH AND WELL BEING 2170 01:38:53,145 --> 01:38:53,946 SURVEY. 2171 01:38:53,946 --> 01:38:55,614 MANY SURVEYS ARE HIGH LEVEL 2172 01:38:55,614 --> 01:38:56,148 BECAUSE WE'RE SO DISEASE 2173 01:38:56,148 --> 01:39:05,724 AGNOSTIC. 2174 01:39:05,724 --> 01:39:09,328 IT WILL TAKE AN ANCILLARY STUDY 2175 01:39:09,328 --> 01:39:13,832 TO GET A DETAILED SURVEY ON WHAT 2176 01:39:13,832 --> 01:39:14,800 THAT LOOKS LIKE FOR AN 2177 01:39:14,800 --> 01:39:17,002 INDIVIDUAL AND THERE'S QUESTIONS 2178 01:39:17,002 --> 01:39:18,270 ON THE SOCIAL DETERMINATES OF 2179 01:39:18,270 --> 01:39:19,738 HEALTH SURVEY THAT MAY GET TO 2180 01:39:19,738 --> 01:39:19,939 THAT. 2181 01:39:19,939 --> 01:39:21,407 I WOULD SAY IT'S HIGH LEVEL 2182 01:39:21,407 --> 01:39:23,876 RIGHT NOW THOUGH. 2183 01:39:23,876 --> 01:39:24,977 >> THANK YOU. 2184 01:39:24,977 --> 01:39:30,416 >> MAKE -- BLAKE WARNER HAS A 2185 01:39:30,416 --> 01:39:31,050 QUESTION. 2186 01:39:31,050 --> 01:39:32,885 >> THIS IS DOWN THE ROAD I WOULD 2187 01:39:32,885 --> 01:39:35,387 GUESS BUT ARE THERE PLANS TO 2188 01:39:35,387 --> 01:39:39,325 PULL OTHER HUMAN DATA SETS FROM 2189 01:39:39,325 --> 01:39:41,827 TCGA OR GEOOR DB GAP THAT MAY 2190 01:39:41,827 --> 01:39:43,896 LINK TO THE "ALL OF US" DATA 2191 01:39:43,896 --> 01:39:46,932 SETS OR AT LEAST GIVE SOME 2192 01:39:46,932 --> 01:39:47,866 ACQUISITION THAT A MATCHED 2193 01:39:47,866 --> 01:39:51,003 SAMPLE -- AND I WOULD FORESEE 2194 01:39:51,003 --> 01:39:53,939 THAT LIKE MAYBE THE FURTHEST 2195 01:39:53,939 --> 01:39:56,008 ALONG MIGHT BE LIKE ANSWER DATA 2196 01:39:56,008 --> 01:39:58,143 SEQUENCING DATA OF TUMORS, SO 2197 01:39:58,143 --> 01:40:03,882 YOU COULD REALLY DO THIS BROAD 2198 01:40:03,882 --> 01:40:04,917 TRANSCRIPTIONAL ANALYSIS OR 2199 01:40:04,917 --> 01:40:06,986 PROTEOMIC ANALYSES. 2200 01:40:06,986 --> 01:40:08,721 IT'S ALREADY PUBLICALLY 2201 01:40:08,721 --> 01:40:10,422 AVAILABLE BUT OVERLAY IT WITH 2202 01:40:10,422 --> 01:40:11,023 GENOME. 2203 01:40:11,023 --> 01:40:12,558 >> TWO THINGS TO THAT POINT. 2204 01:40:12,558 --> 01:40:14,360 WE'RE WORKING ON WAYS FOR PEOPLE 2205 01:40:14,360 --> 01:40:16,428 TO BRING DATA TO ALL OF US IN 2206 01:40:16,428 --> 01:40:19,365 THEIR OWN WORK SPACES SO THEY 2207 01:40:19,365 --> 01:40:24,036 CAN DO ANALYSES SIDE BY SIDE. 2208 01:40:24,036 --> 01:40:25,671 THAT'S A LITTLE CLUNKY BUT WHAT 2209 01:40:25,671 --> 01:40:27,640 WE'RE IMPROVING TO MAKE SURE WE 2210 01:40:27,640 --> 01:40:30,209 CAN DO THAT. 2211 01:40:30,209 --> 01:40:34,246 AND CERTAINLY THINKING ABOUT HOW 2212 01:40:34,246 --> 01:40:35,848 DO WE KNOW NOT ONLY WHO IS IN 2213 01:40:35,848 --> 01:40:38,117 THE DATA SETS AND IN ALL OF US 2214 01:40:38,117 --> 01:40:40,486 BUT IN THE LARGE COHORT STUDIES 2215 01:40:40,486 --> 01:40:42,087 NIH IS FUNDING ACROSS THE BOARD 2216 01:40:42,087 --> 01:40:43,922 THAT MAY HAVE MUCH DEEPER 2217 01:40:43,922 --> 01:40:45,290 PHENOTYPING INFORMATION WE DON'T 2218 01:40:45,290 --> 01:40:47,359 HAVE ACCESS TO YET SO WE CAN 2219 01:40:47,359 --> 01:40:50,129 BRING THOSE THINGS TOGETHER. 2220 01:40:50,129 --> 01:40:51,397 THESE ARE THINGS WE HAVE PLANS 2221 01:40:51,397 --> 01:40:53,932 FOR AND CONCEPTS FOR BUT ARE NOT 2222 01:40:53,932 --> 01:40:55,067 CURRENTLY IN PLACE. 2223 01:40:55,067 --> 01:40:59,471 I WILL ALSO SAY WE ARE ALSO 2224 01:40:59,471 --> 01:41:04,510 DOING PILOTS AND MULTIOPICS AND 2225 01:41:04,510 --> 01:41:10,049 PILOTS IN RNA SEQ AND ADDITIONAL 2226 01:41:10,049 --> 01:41:20,559 LONG READS COMING WE'LL HAVE 2227 01:41:21,060 --> 01:41:24,596 DATA FROM EXPOSOMICS AN 2228 01:41:24,596 --> 01:41:26,065 ANCILLARY STUDY THAT JUST 2229 01:41:26,065 --> 01:41:27,900 LAUNCHED AND WE'RE GOING TO 2230 01:41:27,900 --> 01:41:30,569 START TO HAVE INDIVIDUALS THAT 2231 01:41:30,569 --> 01:41:35,708 HAVE ALL THE DIFFERENT DATA TYPE 2232 01:41:35,708 --> 01:41:37,142 BECAUSE WE'RE USING THE SAMPLE 2233 01:41:37,142 --> 01:41:39,445 TO GET A DEEP DATA SET ON THE 2234 01:41:39,445 --> 01:41:40,012 INDIVIDUALS. 2235 01:41:40,012 --> 01:41:43,882 I'LL SAY THE DATA SET IS 2236 01:41:43,882 --> 01:41:52,958 ENRICHED FOR DIVERSITY. 2237 01:41:52,958 --> 01:41:54,326 AND THERE'S TECHNOLOGIES COMING 2238 01:41:54,326 --> 01:41:59,198 OUT. 2239 01:41:59,198 --> 01:42:00,833 I LIKE THE IDEA OF WORKING WITH 2240 01:42:00,833 --> 01:42:01,700 AMP AND OTHER GROUP. 2241 01:42:01,700 --> 01:42:03,869 I PUT MY E-MAIL IN THE CHAT SO 2242 01:42:03,869 --> 01:42:06,138 IF ANYONE HAS IDEAS AND WANTS TO 2243 01:42:06,138 --> 01:42:07,606 BRAIN STORM AND TALK THROUGH 2244 01:42:07,606 --> 01:42:09,641 THEM, I CAN DO IT OR POINT YOU 2245 01:42:09,641 --> 01:42:10,843 IN THE RIGHT DIRECTION OF WHO 2246 01:42:10,843 --> 01:42:13,112 THE RIGHT PERSON TO TALK SO IS. 2247 01:42:13,112 --> 01:42:14,847 -- TALK TO IS. 2248 01:42:14,847 --> 01:42:19,384 >> WONDERFUL. 2249 01:42:19,384 --> 01:42:21,920 >> WITH THANKS SO MUCH AND 2250 01:42:21,920 --> 01:42:25,157 PLEASE DO REACH OUT TO ALL OF US 2251 01:42:25,157 --> 01:42:26,558 COLLEAGUES BECAUSE I THINK 2252 01:42:26,558 --> 01:42:27,226 THERE'S WONDERFUL OPPORTUNITIES 2253 01:42:27,226 --> 01:42:33,332 FOR ORAL HEALTH THAT WILL ONLY 2254 01:42:33,332 --> 01:42:34,933 GROW AS WE TAKE ADDITIONAL MERGE 2255 01:42:34,933 --> 01:42:36,869 AND DATA SETS WITH ORAL HEALTH 2256 01:42:36,869 --> 01:42:39,872 AND GREAT OPPORTUNITIES FOR OUR 2257 01:42:39,872 --> 01:42:43,876 WORKFORCE. 2258 01:42:43,876 --> 01:42:45,778 CRITICAL TO OUR FIELD IS 2259 01:42:45,778 --> 01:42:47,880 INTEGRATE BEING RESEARCH TO 2260 01:42:47,880 --> 01:42:48,113 CLINIC. 2261 01:42:48,113 --> 01:42:49,815 -- INTEGRATING RESEARCH TO 2262 01:42:49,815 --> 01:42:50,048 CLINIC. 2263 01:42:50,048 --> 01:42:51,583 HAVING THE WORKFORCE CAPACITY TO 2264 01:42:51,583 --> 01:42:53,952 DO THAT THROUGH THE TRAINING OF 2265 01:42:53,952 --> 01:42:59,958 CLINICIAN SCIENTISTS IS PIVOTAL. 2266 01:42:59,958 --> 01:43:02,161 AND WE MENTIONED THE COUNCIL FOR 2267 01:43:02,161 --> 01:43:03,362 DATA EARLIER AND TODAY WE'LL 2268 01:43:03,362 --> 01:43:08,667 HEAR FROM THE COUNCIL WORKING 2269 01:43:08,667 --> 01:43:11,403 GROUP ON CLINICIAN SCIENTIST 2270 01:43:11,403 --> 01:43:11,870 TRAINING AND DISCUSS 2271 01:43:11,870 --> 01:43:13,572 RECOMMENDATIONS WITH A FOCUS ON 2272 01:43:13,572 --> 01:43:16,975 THE EXECUTIVE SUMMARY OF THE 2273 01:43:16,975 --> 01:43:21,980 FINDINGS OF THE COMMITTEE THAT 2274 01:43:21,980 --> 01:43:25,617 WAS LED BY DR. GRAZE. 2275 01:43:25,617 --> 01:43:25,951 DR. GRAVES. 2276 01:43:25,951 --> 01:43:26,485 >> THANK YOU. 2277 01:43:26,485 --> 01:43:27,886 CAN YOU HEAR ME? 2278 01:43:27,886 --> 01:43:28,620 >> YES. 2279 01:43:28,620 --> 01:43:28,887 >> OKAY. 2280 01:43:28,887 --> 01:43:39,398 I'M GOING TO SHARE MY SCREEN. 2281 01:44:16,802 --> 01:44:23,842 THE CHARGE WAS TO BUILD A 2282 01:44:23,842 --> 01:44:24,710 DIVERSE WORKFORCE. 2283 01:44:24,710 --> 01:44:27,112 THE COMMITTEE WORKED ALMOST TWO 2284 01:44:27,112 --> 01:44:32,718 YEARS AND WORKED DILIGENTLY ON 2285 01:44:32,718 --> 01:44:37,589 THIS. 2286 01:44:37,589 --> 01:44:38,757 ALL MEMBERS WORKED HARD TO 2287 01:44:38,757 --> 01:44:45,597 PRODUCE THIS REPORT. 2288 01:44:45,597 --> 01:44:46,598 THE WORKFORCE RECOGNIZED THERE'S 2289 01:44:46,598 --> 01:44:47,866 LITTLE INFORMATION TO ASSESS THE 2290 01:44:47,866 --> 01:44:51,503 WORKFORCE AND TO ADDRESS THE 2291 01:44:51,503 --> 01:44:53,138 LIMITATION AN RFI WAS DEVELOPED 2292 01:44:53,138 --> 01:44:58,644 AND LEARNING SESSIONS HELD. 2293 01:44:58,644 --> 01:45:01,380 THE WORKING GROUP RECOGNIZED THE 2294 01:45:01,380 --> 01:45:02,848 IMPORTANCE OF DEI BUT FELT IT 2295 01:45:02,848 --> 01:45:05,984 WAS A COMPLEX ISSUE AND REQUIRED 2296 01:45:05,984 --> 01:45:09,488 A SEPARATE ANALYSIS. 2297 01:45:09,488 --> 01:45:11,857 THE CHALLENGES WERE BROUGHT 2298 01:45:11,857 --> 01:45:14,826 FORTH THROUGH THE RFI SUBMITTED 2299 01:45:14,826 --> 01:45:15,627 THROUGH SEVERAL LEARNING 2300 01:45:15,627 --> 01:45:17,396 SESSIONS THEY ARE INCLUDE THE 2301 01:45:17,396 --> 01:45:19,298 FACT THAT RELATIVELY LITTLES IS 2302 01:45:19,298 --> 01:45:24,436 KNOWN ABOUT FACTORS THAT PROMOTE 2303 01:45:24,436 --> 01:45:26,738 RECRUITMENT OF TRAINING AND 2304 01:45:26,738 --> 01:45:27,673 FACTORS THAT DETERMINE THE 2305 01:45:27,673 --> 01:45:28,340 LONG-TERM SUCCESSION OF TRAINING 2306 01:45:28,340 --> 01:45:34,046 IN CAREER DEVELOPMENT PROGRAMS. 2307 01:45:34,046 --> 01:45:35,914 AND DENTAL SCHOOLS LACK THE 2308 01:45:35,914 --> 01:45:41,520 STRUCTURE TO SUPPORT MANY 2309 01:45:41,520 --> 01:45:42,487 FULL-TIME RESEARCH PHYSICIANS 2310 01:45:42,487 --> 01:45:44,957 AND PROTECTIVE RESEARCH TIME TO 2311 01:45:44,957 --> 01:45:45,557 SIGNIFICANTLY CONTRIBUTE TO 2312 01:45:45,557 --> 01:45:49,628 RESEARCH ACTIVITIES. 2313 01:45:49,628 --> 01:45:55,834 ANOTHER KEY FINDING WAS THAT 2314 01:45:55,834 --> 01:45:59,871 THERE'S INADEQUATE MENTORING 2315 01:45:59,871 --> 01:46:09,147 DURING TRANSITION TO 2316 01:46:09,147 --> 01:46:19,358 INDEPENDENCE. 2317 01:46:19,358 --> 01:46:23,095 K AWARDS THAT HAVE INSUFFICIENT 2318 01:46:23,095 --> 01:46:25,764 RESEARCH FUNDS AND A GENERAL 2319 01:46:25,764 --> 01:46:27,399 INSUFFICIENT AWARENESS OF ALL 2320 01:46:27,399 --> 01:46:32,471 THE OPPORTUNITIES THAT NIDCR S 2321 01:46:32,471 --> 01:46:43,015 FOR TRAINING AND RECOMMENDATIONS 2322 01:46:45,283 --> 01:46:46,785 WERE DEVELOPED WITH THE 2323 01:46:46,785 --> 01:46:48,153 FOLLOWING GOALS IN MIND. 2324 01:46:48,153 --> 01:46:51,890 TO ENHANCE THE SUCCESS OF 2325 01:46:51,890 --> 01:46:55,961 TRAINEES AND EARLY STAGE 2326 01:46:55,961 --> 01:46:58,163 INVESTIGAT 2327 01:46:58,163 --> 01:46:59,197 INVESTIGATORS AND ENHANCE 2328 01:46:59,197 --> 01:47:01,933 TRAINING AND PROMOTE GREATER 2329 01:47:01,933 --> 01:47:05,670 OPPORTUNITIES IN RESEARCH AND 2330 01:47:05,670 --> 01:47:07,906 INCREASE OUTREACH MAKE DOC 2331 01:47:07,906 --> 01:47:11,877 RESEARCH TRAINING MORE APPEALING 2332 01:47:11,877 --> 01:47:13,512 AND REDUCE FINANCIAL 2333 01:47:13,512 --> 01:47:13,812 LIMITATIONS. 2334 01:47:13,812 --> 01:47:15,881 WITH THESE CHALLENGES IN MIND 2335 01:47:15,881 --> 01:47:18,483 THE FOLLOWING RECOMMENDATIONS 2336 01:47:18,483 --> 01:47:20,519 WERE MADE. 2337 01:47:20,519 --> 01:47:23,855 THEY WERE DEVELOPED AROUND FOUR 2338 01:47:23,855 --> 01:47:24,589 DIFFERENT APPROACHES. 2339 01:47:24,589 --> 01:47:27,292 ONE INCLUDED DEVELOPMENT OF AN 2340 01:47:27,292 --> 01:47:31,530 OFFICE TO FOSTER COLLABORATION. 2341 01:47:31,530 --> 01:47:32,431 SEVERAL ORGANIZATIONS EXPRESSED 2342 01:47:32,431 --> 01:47:37,769 AN INTEREST IN PART, THE WITH 2343 01:47:37,769 --> 01:47:40,238 NIDCR BUT INDICATE A LIMITING 2344 01:47:40,238 --> 01:47:42,874 FACTOR IN DEVELOPING 2345 01:47:42,874 --> 01:47:43,575 PARTNERSHIPS IS THE LACK OF A 2346 01:47:43,575 --> 01:47:51,516 CONTACT PERSON. 2347 01:47:51,516 --> 01:47:52,250 TO ADDRESS THIS ONE 2348 01:47:52,250 --> 01:47:53,985 RECOMMENDATION IS A CONTACT 2349 01:47:53,985 --> 01:47:59,858 PERSON TO FACILITATE ENGAGEMENT 2350 01:47:59,858 --> 01:48:03,528 IN PROFESSIONALS AND ORAL HEALTH 2351 01:48:03,528 --> 01:48:09,034 INDUSTRY AND PERTAINS TO THE 2352 01:48:09,034 --> 01:48:10,735 PRESENTATION GIVEN BEFORE ME IN 2353 01:48:10,735 --> 01:48:15,874 WHICH GREATER ENGAGEMENT WAS AN 2354 01:48:15,874 --> 01:48:17,008 ISSUE THE GROUP FACED. 2355 01:48:17,008 --> 01:48:20,645 TO PROMOTE PARTNERSHIPS TO 2356 01:48:20,645 --> 01:48:25,217 ENHANCE MENTORSHIP WITH AN 2357 01:48:25,217 --> 01:48:26,284 EMPHASIS ON CLINICIAN SCIENTIST 2358 01:48:26,284 --> 01:48:30,021 AND EARLY STAGE INVESTIGATORS IT 2359 01:48:30,021 --> 01:48:31,823 COULD HELP INCREASE NETWORK 2360 01:48:31,823 --> 01:48:34,426 OPPORTUNITIES FOR TRAINEES AND 2361 01:48:34,426 --> 01:48:41,333 DSI AND FACILITATE INTERACTIONS 2362 01:48:41,333 --> 01:48:43,001 BETWEEN LEADERS OF ORGANIZATIONS 2363 01:48:43,001 --> 01:48:47,873 TO ENHANCE PROGRAM DEVELOPMENT. 2364 01:48:47,873 --> 01:48:50,876 AND LEAD IN INNOVATIVE PROGRAMS 2365 01:48:50,876 --> 01:48:53,078 THAT PROVIDE RESEARCH AND 2366 01:48:53,078 --> 01:48:57,782 CLINICAL TEACHING AND PROMOTE 2367 01:48:57,782 --> 01:48:58,583 RESEARCH IN NIDCR OPPORTUNITIES 2368 01:48:58,583 --> 01:49:04,189 AND COULD ENHANCE OUTREACH. 2369 01:49:04,189 --> 01:49:05,724 AND ANOTHER RECOMMENDATION IS TO 2370 01:49:05,724 --> 01:49:06,992 ESTABLISH A CENTER TO ASSESS 2371 01:49:06,992 --> 01:49:08,093 TRAINING PROGRAMS AND CAREER 2372 01:49:08,093 --> 01:49:11,663 DEVELOPMENT OUTCOMES. 2373 01:49:11,663 --> 01:49:14,065 THIS COULD BE ACCOMPLISHED BY 2374 01:49:14,065 --> 01:49:17,969 DEVELOPING AN RFA OR CENTER THAT 2375 01:49:17,969 --> 01:49:20,138 DEVELOPS TRAINING GOALS, METRICS 2376 01:49:20,138 --> 01:49:27,879 AND ANALYZES OUTCOMES. 2377 01:49:27,879 --> 01:49:33,418 AND DEVELOP AND MONITOR OUTCOME 2378 01:49:33,418 --> 01:49:34,052 METRICS, COORDINATE EVALUATION 2379 01:49:34,052 --> 01:49:35,754 AND TRACK TRAINEES AND SERVE AS 2380 01:49:35,754 --> 01:49:39,357 A CENTRAL DATA REPOSITORY. 2381 01:49:39,357 --> 01:49:43,395 THE CENTER WOULD ALSO ANALYZE 2382 01:49:43,395 --> 01:49:45,230 DATA, INSIGHT AS TO PROGRAM 2383 01:49:45,230 --> 01:49:50,435 FACTORS AND TRAINEE FACTORS THAT 2384 01:49:50,435 --> 01:49:52,737 LEAD TO SUCCESS. 2385 01:49:52,737 --> 01:49:54,940 THE CENTER COULD ALSO CONSULT 2386 01:49:54,940 --> 01:49:58,343 WITH TRAINING PROGRAMS AND GUIDE 2387 01:49:58,343 --> 01:49:59,544 SELF-ASSESSMENT AND EVALUATION 2388 01:49:59,544 --> 01:50:02,147 AND PROVIDE DATA ANALYSIS TO 2389 01:50:02,147 --> 01:50:03,915 NIDCR TO ASSESS THE TYPES AND 2390 01:50:03,915 --> 01:50:05,350 LEVEL OF SUPPORT FOR TRAINING 2391 01:50:05,350 --> 01:50:13,191 AND CAREER DEVELOPMENT PROGRAMS. 2392 01:50:13,191 --> 01:50:17,128 THERE'S THE CREATION OF A 2393 01:50:17,128 --> 01:50:18,029 FUNDING OPPORTUNITIES THAT PAIR 2394 01:50:18,029 --> 01:50:22,000 AN EARLY STAGE INVESTIGATOR WITH 2395 01:50:22,000 --> 01:50:24,035 AN ESTABLISHED INVESTIGATOR AS 2396 01:50:24,035 --> 01:50:29,741 MPI OR CO-INVESTIGATOR, 2397 01:50:29,741 --> 01:50:30,308 EXPANSION OF PROGRAMS AND 2398 01:50:30,308 --> 01:50:33,645 PROVIDE INCENTIVES FOR EARLY 2399 01:50:33,645 --> 01:50:34,246 STAGE INVESTIGATOR CLINICIAN 2400 01:50:34,246 --> 01:50:40,685 SCIENTISTS. 2401 01:50:40,685 --> 01:50:43,521 AND THE SUPPORT OF LOCAL, 2402 01:50:43,521 --> 01:50:44,356 REGIONAL AND VIRTUAL RESEARCH 2403 01:50:44,356 --> 01:50:46,891 CONFERENCES THAT ARE TAILORED 2404 01:50:46,891 --> 01:50:49,861 FOR TRAINEES AND PSIs. 2405 01:50:49,861 --> 01:50:50,929 ESTABLISH RESEARCH TRAINING 2406 01:50:50,929 --> 01:50:55,900 PROGRAMS FOR CLINICIANS AT ALL 2407 01:50:55,900 --> 01:50:57,602 STAGES OF TRAINING OR CAREER 2408 01:50:57,602 --> 01:50:59,237 DEVELOPMENT AND TO DEVELOP 2409 01:50:59,237 --> 01:51:01,840 INITIATIVES TO FOSTER INNOVATIVE 2410 01:51:01,840 --> 01:51:07,112 TRAINING PROGRAMS THAT INCLUDE 2411 01:51:07,112 --> 01:51:11,249 PROHIBIT DEVELOPMENT. 2412 01:51:11,249 --> 01:51:15,086 AND ULTIMATELY ENHANCE CAREER 2413 01:51:15,086 --> 01:51:15,887 OPPORTUNITIES. 2414 01:51:15,887 --> 01:51:19,824 THESE INCLUDE INCORPORATION OF 2415 01:51:19,824 --> 01:51:23,895 INTERNSHIP TO INDUSTRY AND 2416 01:51:23,895 --> 01:51:24,529 ENCOURAGE ENTREPRENEURSHIP AND 2417 01:51:24,529 --> 01:51:26,431 SKILL ACQUISITION AS PART OF 2418 01:51:26,431 --> 01:51:31,503 TRAINING FOR CAREER DEVELOPMENT 2419 01:51:31,503 --> 01:51:35,073 PROGRAMS AND OPTIONS FOR GRANT 2420 01:51:35,073 --> 01:51:37,776 OR SUPPLEMENTAL AWARDS, TO WORK 2421 01:51:37,776 --> 01:51:39,077 WITH DENTAL SCHOOLS TO INCREASE 2422 01:51:39,077 --> 01:51:42,047 THE NUMBER OF FACULTY POSITIONS 2423 01:51:42,047 --> 01:51:43,915 THAT INCORPORATE CLINICAL 2424 01:51:43,915 --> 01:51:44,683 TEACHING WITH PROTECTIVE 2425 01:51:44,683 --> 01:51:47,719 RESEARCH TIME AND THE 2426 01:51:47,719 --> 01:51:49,821 DEVELOPMENT OF INTERDISCIPLINARY 2427 01:51:49,821 --> 01:51:51,256 OPPORTUNITIES FOR CLINICIAN 2428 01:51:51,256 --> 01:51:54,059 SCIENTIST COMBINE ORAL HEALTH 2429 01:51:54,059 --> 01:51:55,393 WITH OTHER FIELDS SUCH AS 2430 01:51:55,393 --> 01:52:03,335 COMPUTATIONAL SCIENCES. 2431 01:52:03,335 --> 01:52:04,436 RECOMMENDATIONS INCLUDE NUMBER 2432 01:52:04,436 --> 01:52:06,037 ONE ESTABLISHMENT OF AN OFFICE 2433 01:52:06,037 --> 01:52:13,278 THAT PROMOTES PARTNERSHIPS TO 2434 01:52:13,278 --> 01:52:15,547 IMPROVE OUTREACH, RESEARCH 2435 01:52:15,547 --> 01:52:17,649 OPPORTUNITIES AND PROGRAMS THAT 2436 01:52:17,649 --> 01:52:18,383 WOULD ENHANCE CLINICIAN 2437 01:52:18,383 --> 01:52:21,186 SCIENTIST CAREER DEVELOPMENT AND 2438 01:52:21,186 --> 01:52:21,453 TRAINING. 2439 01:52:21,453 --> 01:52:22,620 DEVELOPMENT OF GRANT PROGRAMS 2440 01:52:22,620 --> 01:52:24,989 THAT PROMOTE MENTORSHIP AT 2441 01:52:24,989 --> 01:52:27,659 MULTIPLE STAGES OF TRAINING AND 2442 01:52:27,659 --> 01:52:29,361 CAREER DEVELOPMENT AND PROGRAMS 2443 01:52:29,361 --> 01:52:34,165 THAT REDUCE FINANCIAL OPTICALS. 2444 01:52:34,165 --> 01:52:35,333 AND THE THIRD -- OBSTACLES. 2445 01:52:35,333 --> 01:52:40,305 THE THIRD IS TO FUND A CENTER TO 2446 01:52:40,305 --> 01:52:42,040 ASSESS TRAINING PROGRAMS, 2447 01:52:42,040 --> 01:52:43,908 TRAINEES AND CAREER OUTCOMES TO 2448 01:52:43,908 --> 01:52:46,945 ESTABLISH METRICS, COLLECT DATA 2449 01:52:46,945 --> 01:52:48,580 AND PROVIDE DATA ANALYSIS 2450 01:52:48,580 --> 01:52:50,615 REGARDING SPECIFIC ASPECTS OF 2451 01:52:50,615 --> 01:52:52,016 TRAINEES AND CAREER DEVELOPMENT 2452 01:52:52,016 --> 01:53:00,425 PROGRAMS THAT ARE SUCCESSFUL. 2453 01:53:00,425 --> 01:53:01,292 AND LOOK AT PROGRAMS THAT 2454 01:53:01,292 --> 01:53:05,463 PROVIDE INCENTIVES FOR EARLY 2455 01:53:05,463 --> 01:53:07,399 STAGE INVESTIGATORS CLINICIAN 2456 01:53:07,399 --> 01:53:08,833 SCIENTISTS AND CLINICAL TEACHING 2457 01:53:08,833 --> 01:53:13,872 AND PROTECTIVE RESEARCH TIME. 2458 01:53:13,872 --> 01:53:17,242 THAT'S A VERY BRIEF SUMMARY OF 2459 01:53:17,242 --> 01:53:19,110 THE RECOMMENDATIONS THAT WERE 2460 01:53:19,110 --> 01:53:20,912 DEVELOPED BY THE COMMITTEE AND A 2461 01:53:20,912 --> 01:53:23,148 FULL REPORT WILL BE RELEASED IN 2462 01:53:23,148 --> 01:53:24,048 THE NEAR FUTURE. 2463 01:53:24,048 --> 01:53:30,155 SO THANK YOU VERY MUCH. 2464 01:53:30,155 --> 01:53:32,757 >> THANK YOU, DR. GRAVES. 2465 01:53:32,757 --> 01:53:35,059 ONE QUICK COMMENT REGARDING 2466 01:53:35,059 --> 01:53:37,929 WORKING GROUPS OF COUNCIL, 2467 01:53:37,929 --> 01:53:43,435 WORKING GROUPS ARE ESTABLISHED 2468 01:53:43,435 --> 01:53:45,203 TO PROVIDE RECOMMENDATIONS TO 2469 01:53:45,203 --> 01:53:46,771 COUNCIL MEMBERS THEMSELVES AND 2470 01:53:46,771 --> 01:53:47,605 COUNCIL MEMBERS HAVE THE 2471 01:53:47,605 --> 01:53:56,648 RESPONSE TO ADVISE THE DIRECTOR. 2472 01:53:56,648 --> 01:53:58,116 AND THE COUNCIL MEMBERS ADVISE 2473 01:53:58,116 --> 01:53:59,717 THE DIRECTOR ON NEXT STEPS. 2474 01:53:59,717 --> 01:54:03,888 SO WHAT WE'RE LOOKING FOR IS 2475 01:54:03,888 --> 01:54:05,356 COUNCIL'S DISCUSSION OF THE 2476 01:54:05,356 --> 01:54:15,900 CONCEPT AND THIS WORKING GROUP 2477 01:54:16,501 --> 01:54:18,069 RECOMMENDATIONS AND IF THERE'S 2478 01:54:18,069 --> 01:54:26,211 ADDITIONAL CONSIDERATIONS. 2479 01:54:26,211 --> 01:54:30,482 >> THANK YOU, DANA AND THE TEAM 2480 01:54:30,482 --> 01:54:38,723 FOR THIS SPRE IMPORTANT WORK. 2481 01:54:38,723 --> 01:54:44,696 COULD YOU EXPAND ON HOW THE 2482 01:54:44,696 --> 01:54:47,699 NIDCR COULD INTERACT WITH DENTAL 2483 01:54:47,699 --> 01:54:51,402 SCHOOLS TO HELP SUPPORT THE 2484 01:54:51,402 --> 01:54:55,907 FACULTY LINES THAT INCLUDE TIME 2485 01:54:55,907 --> 01:54:56,441 PROTECTED FOR RESEARCH. 2486 01:54:56,441 --> 01:55:05,783 >> THAT'S A KEY POINT. 2487 01:55:05,783 --> 01:55:09,220 I'LL GIVE YOU ONE EXAMPLE. 2488 01:55:09,220 --> 01:55:10,154 THE K AWARDS LIMIT CLINICAL 2489 01:55:10,154 --> 01:55:19,898 TEACHING. 2490 01:55:19,898 --> 01:55:22,400 A RESEARCH SCIENTIST CAN SPEND 2491 01:55:22,400 --> 01:55:27,906 70% OF THE TIME CONSTITUTED NOW 2492 01:55:27,906 --> 01:55:31,543 AND THAT LEADS AND LEAVES 20% 2493 01:55:31,543 --> 01:55:32,343 CHANCE TO PRACTICE AND THEN 2494 01:55:32,343 --> 01:55:33,511 THERE'S NO TIME FOR CLINICAL 2495 01:55:33,511 --> 01:55:33,845 TEACHING. 2496 01:55:33,845 --> 01:55:39,884 THIS IS A PROBLEM FOR DENTAL 2497 01:55:39,884 --> 01:55:46,391 SCHOOLS ONE SOLUTION IS TO 2498 01:55:46,391 --> 01:55:47,692 REDUCE THE RESEARCH COMMITMENT 2499 01:55:47,692 --> 01:55:49,561 TO 40%. 2500 01:55:49,561 --> 01:55:57,201 IF IT WAS 40% IT COULD BE 20% 2501 01:55:57,201 --> 01:55:59,571 CLINICAL PRACTICE AND 20-40, 2502 01:55:59,571 --> 01:56:02,907 20-40 AND ONE WAY TO EXPAND THE 2503 01:56:02,907 --> 01:56:04,709 ABILITY OF CLINICIAN SCIENTIST 2504 01:56:04,709 --> 01:56:08,646 TO PARTICIPATE IN CLINICAL 2505 01:56:08,646 --> 01:56:11,549 RESEARCH OR EVEN BASIC RESEARCH. 2506 01:56:11,549 --> 01:56:13,551 CLINICAL PRACTICE AS WELL AS 2507 01:56:13,551 --> 01:56:14,218 CLINICAL TEACHING. 2508 01:56:14,218 --> 01:56:19,023 I THINK THIS TYPE OF APPROACH 2509 01:56:19,023 --> 01:56:24,128 KEEPING CLINICIAN SCIENTISTS IN 2510 01:56:24,128 --> 01:56:30,134 MIND THAT'S SOMETHING THAT COULD 2511 01:56:30,134 --> 01:56:39,911 BE CONSIDERED. 2512 01:56:39,911 --> 01:56:43,081 >> THANK YOU FOR THIS REPORT. 2513 01:56:43,081 --> 01:56:44,916 AND PULL ON THE COMMENT I WORK 2514 01:56:44,916 --> 01:56:47,051 IN A CLINICAL DEPARTMENT AT WASH 2515 01:56:47,051 --> 01:56:50,154 U AND ONE OF THE MAIN PROBLEMS 2516 01:56:50,154 --> 01:56:52,824 WE HAVE IN PHYSICIAN SCIENTISTS 2517 01:56:52,824 --> 01:56:57,895 IS IT HAS TO PAY. 2518 01:56:57,895 --> 01:57:05,670 I WONDER IF AND STILL GETTING 2519 01:57:05,670 --> 01:57:07,905 THE CLINICIAN SALARY AND BRING 2520 01:57:07,905 --> 01:57:12,443 IN REVENUE TO THE DEPARTMENT. 2521 01:57:12,443 --> 01:57:18,916 SO AND HOW WILL IT BE ABLE TO 2522 01:57:18,916 --> 01:57:20,218 SUPPORT? 2523 01:57:20,218 --> 01:57:24,122 AND PHYSICIAN SCIENTISTS TO 2524 01:57:24,122 --> 01:57:29,260 SPEND TIME AND SOMETIMES IT'S A 2525 01:57:29,260 --> 01:57:39,804 PROBLEM FOR THE DEPARTMENT AND 2526 01:57:40,338 --> 01:57:41,873 THIS APPLIES TO OTHER 2527 01:57:41,873 --> 01:57:43,141 DEPARTMENTS IT'S A BIG PROBLEM 2528 01:57:43,141 --> 01:57:49,414 TO RETAIN CLINICIANS TO STAY IN 2529 01:57:49,414 --> 01:57:51,849 ACADEMIA AND SOMETIMES GO BACK 2530 01:57:51,849 --> 01:57:55,720 TO THE WHAT I MENTIONED AND WHAT 2531 01:57:55,720 --> 01:57:59,957 WE COULD PROVIDE TOGETHER WITH 2532 01:57:59,957 --> 01:58:00,892 NIH. 2533 01:58:00,892 --> 01:58:03,594 >> YEAH, SO WITH MORE DENTAL 2534 01:58:03,594 --> 01:58:05,697 SCHOOLS AND FEWER FACULTY YOU 2535 01:58:05,697 --> 01:58:07,298 HAVE MORE COMPETITION FOR 2536 01:58:07,298 --> 01:58:09,067 FACULTY WHICH RAISES SALARY. 2537 01:58:09,067 --> 01:58:11,402 YOU HAVE MULTIPLE FACTORS THAT 2538 01:58:11,402 --> 01:58:14,105 ARE REALLY MAKING IT DIFFICULT 2539 01:58:14,105 --> 01:58:16,974 FOR DENTAL SCHOOLS TO HIRE 2540 01:58:16,974 --> 01:58:19,911 CLINICAL FACULTY TO DO RESEARCH. 2541 01:58:19,911 --> 01:58:30,088 I THINK THAT IS A MAJOR ISSUE. 2542 01:58:30,088 --> 01:58:34,559 ONE POTENTIAL AVENUE IS TO 2543 01:58:34,559 --> 01:58:36,694 DEVELOP A PROGRAM WHERE YOUR 2544 01:58:36,694 --> 01:58:39,564 RESEARCH COMPONENT WAS FUNDED BY 2545 01:58:39,564 --> 01:58:41,299 NIDCR AND FACULTY COMPONENT 2546 01:58:41,299 --> 01:58:43,601 RELATED TO TEACHING WAS FUNDED 2547 01:58:43,601 --> 01:58:46,471 BY A PROFESSIONAL SOCIETY. 2548 01:58:46,471 --> 01:58:49,440 SO THIS WOULD NOT VIOLATE 2549 01:58:49,440 --> 01:58:53,077 PRINCIPLES BUT THERE'S A VERY 2550 01:58:53,077 --> 01:58:53,878 MAJOR CONCERN FROM THE 2551 01:58:53,878 --> 01:58:55,947 PROFESSIONAL SOCIETIES THEY 2552 01:58:55,947 --> 01:58:58,549 CANNOT RETAIN CLINICIAN 2553 01:58:58,549 --> 01:59:00,718 SCIENTISTS TO TEACH. 2554 01:59:00,718 --> 01:59:01,486 THEY'RE VERY INTERESTED IN THIS 2555 01:59:01,486 --> 01:59:06,124 TYPE OF PROGRAM. 2556 01:59:06,124 --> 01:59:10,261 THERE ARE PROGRAMS WITH ASB AND 2557 01:59:10,261 --> 01:59:11,596 R THAT COMBINE FOUNDATION 2558 01:59:11,596 --> 01:59:17,568 SUPPORT COUPLED WITH NIH 2559 01:59:17,568 --> 01:59:17,802 SUPPORT. 2560 01:59:17,802 --> 01:59:21,439 YOU COULD IMAGINE AND THEY MAY 2561 01:59:21,439 --> 01:59:23,608 BE INTERESTED IN HAVING A K 2562 01:59:23,608 --> 01:59:27,445 AWARD THAT FUNDED 40% OF THE 2563 01:59:27,445 --> 01:59:31,816 RESEARCH ACTIVITY OR ANOTHER NR 2564 01:59:31,816 --> 01:59:32,016 AWARD. 2565 01:59:32,016 --> 01:59:33,451 AND THEY ARE TOOK THOSE 2566 01:59:33,451 --> 01:59:37,121 CANDIDATES AND FUNDED A SALARY 2567 01:59:37,121 --> 01:59:39,323 COMPONENT THAT WOULD HELP THE 2568 01:59:39,323 --> 01:59:39,891 DENTAL SCHOOLS ADDRESS THAT 2569 01:59:39,891 --> 01:59:47,565 ISSUE. 2570 01:59:47,565 --> 01:59:54,672 THIS COULD BE USED AS PART OF 2571 01:59:54,672 --> 01:59:55,907 RETENTION. 2572 01:59:55,907 --> 01:59:57,608 AN ACADEMIC ENVIRONMENT IS 2573 01:59:57,608 --> 02:00:00,211 SPECIAL AND THERE'S A 2574 02:00:00,211 --> 02:00:04,282 WILLINGNESS ON FACULTY IF 2575 02:00:04,282 --> 02:00:05,249 THEY'RE PURSUING SOMETHING 2576 02:00:05,249 --> 02:00:05,917 THEY'RE INTERESTED IN THEY'LL 2577 02:00:05,917 --> 02:00:08,386 STAY IN ACADEMIC AND AN ISSUE 2578 02:00:08,386 --> 02:00:09,954 BROUGHT UP BY TRAINEES AND 2579 02:00:09,954 --> 02:00:11,889 FORMER TRAINEES IS WHEN THEY 2580 02:00:11,889 --> 02:00:15,626 LOOK FOR POSITIONS, THEY'RE 80% 2581 02:00:15,626 --> 02:00:16,194 CLINICAL TEACHING AND 20% 2582 02:00:16,194 --> 02:00:19,130 PRACTICE. 2583 02:00:19,130 --> 02:00:21,232 THEY WERE TRAINED TO DO 2584 02:00:21,232 --> 02:00:21,499 RESEARCH. 2585 02:00:21,499 --> 02:00:22,934 IF THE RESEARCH OPPORTUNITY WAS 2586 02:00:22,934 --> 02:00:24,035 GIVEN TO THEM THEY MAY STAY. 2587 02:00:24,035 --> 02:00:30,174 IT MAY BE AN IMPORTANT PART OF 2588 02:00:30,174 --> 02:00:30,441 RETENTION. 2589 02:00:30,441 --> 02:00:33,911 GIVE THEM CONTINUED RESEARCH 2590 02:00:33,911 --> 02:00:34,579 EXPOSURE. 2591 02:00:34,579 --> 02:00:39,917 AND I THINK DENTAL SCHOOLS HAVE 2592 02:00:39,917 --> 02:00:41,586 A PROBLEM AND PROFESSIONAL 2593 02:00:41,586 --> 02:00:43,821 SOCIETIES HAVE A COMMON PROBLEM 2594 02:00:43,821 --> 02:00:46,324 AND CAN WORK TOGETHER TO HELP 2595 02:00:46,324 --> 02:00:48,392 ADDRESS IT IN A WAY I JUST 2596 02:00:48,392 --> 02:00:48,659 MENTIONED. 2597 02:00:48,659 --> 02:00:55,900 >> STEPHANIE. 2598 02:00:55,900 --> 02:00:58,603 >> WONDERING IF THE WORKING 2599 02:00:58,603 --> 02:01:06,077 GROUP HAD RECOMMENDATIONS BUT 2600 02:01:06,077 --> 02:01:10,681 THE DEPARTMENTS OF BIO MEDICAL 2601 02:01:10,681 --> 02:01:12,316 INFORMATICS THE PLAIN TRAINING 2602 02:01:12,316 --> 02:01:17,255 GROUND FOR INFORMATICIANS RARELY 2603 02:01:17,255 --> 02:01:18,222 INCLUDE INFORMATIC COMPONENTS. 2604 02:01:18,222 --> 02:01:23,895 >> IN THAT RECORD THERE WERE 2605 02:01:23,895 --> 02:01:26,497 SEVERAL RECOMMENDATIONS AND 2606 02:01:26,497 --> 02:01:26,964 ADDITIONAL TRAINING 2607 02:01:26,964 --> 02:01:28,633 OPPORTUNITIES FOR CLINICIANS. 2608 02:01:28,633 --> 02:01:31,636 AND YOU COULD THANK OF LIKE A 2609 02:01:31,636 --> 02:01:33,838 MINI K AWARD INSTEAD OF FIVE 2610 02:01:33,838 --> 02:01:36,874 YEARS AND MAYBE ONE YEAR WHERE A 2611 02:01:36,874 --> 02:01:38,576 CLINICIAN SCIENTIST COULD SPEND 2612 02:01:38,576 --> 02:01:43,114 A YEAR BEING IMMERSED IN A 2613 02:01:43,114 --> 02:01:45,249 MASTER'S PROGRAM IN BIO 2614 02:01:45,249 --> 02:01:47,885 INFORMATICS OR ARTIFICIAL 2615 02:01:47,885 --> 02:01:48,219 INTELLIGENCE. 2616 02:01:48,219 --> 02:01:51,489 YOU COULD EXPAND THE TYPES OF 2617 02:01:51,489 --> 02:01:54,225 TRAINING PROGRAMS THAT EXIST IS 2618 02:01:54,225 --> 02:01:58,529 ONE AVENUE TO ADDRESS THAT. 2619 02:01:58,529 --> 02:02:03,734 THE PROFESSIONAL SOCIETIES FELT 2620 02:02:03,734 --> 02:02:06,237 STRONGLY LET'S SAY 2621 02:02:06,237 --> 02:02:09,106 POST-RESIDENCY PROGRAM THAT WAS 2622 02:02:09,106 --> 02:02:11,842 FUNDED BY NIDCR WOULD BE QUITE 2623 02:02:11,842 --> 02:02:12,076 POPULAR. 2624 02:02:12,076 --> 02:02:14,879 SO THIS HAPPENS IN A LOT OF 2625 02:02:14,879 --> 02:02:16,514 SURGICAL SPECIALTIES WHERE 2626 02:02:16,514 --> 02:02:18,249 THERE'S A RESEARCH COMPONENT 2627 02:02:18,249 --> 02:02:27,158 THAT CAN BE USED POST RESIDENCY 2628 02:02:27,158 --> 02:02:32,663 THAT'S A GAP BETWEEN RESIDENCY 2629 02:02:32,663 --> 02:02:35,166 AND DEVELOP MENTORING AND 2630 02:02:35,166 --> 02:02:37,034 RELATIONSHIPS AND FIELDS LIKE 2631 02:02:37,034 --> 02:02:37,668 ARTIFICIAL INTELLIGENCE THERE'S 2632 02:02:37,668 --> 02:02:41,739 A TREMENDOUS INTEREST IN THAT. 2633 02:02:41,739 --> 02:02:43,007 AND MEDICAL SCHOOLS UP 2634 02:02:43,007 --> 02:02:43,841 PARTICULAR AND SCHOOLS OF ARTS 2635 02:02:43,841 --> 02:02:47,912 AND SCIENCES AND ENGINEERING 2636 02:02:47,912 --> 02:02:51,215 HAVE ADVANCED PROGRAMS THAT 2637 02:02:51,215 --> 02:02:52,783 CLINICIAN SCIENTISTS AND 2638 02:02:52,783 --> 02:02:55,319 DENTISTRY COULD BECOME A PART OF 2639 02:02:55,319 --> 02:02:56,420 AND IT'S A MATTER OF EXPANDING 2640 02:02:56,420 --> 02:02:58,990 THE OPPORTUNITIES. 2641 02:02:58,990 --> 02:03:01,559 THIS IS AN AREA WHERE 2642 02:03:01,559 --> 02:03:02,593 PROFESSIONALS SAID THEY'D LIKE 2643 02:03:02,593 --> 02:03:05,062 TO PARTNER WITH NIDCR IN 2644 02:03:05,062 --> 02:03:05,696 PRESENTING THE OPPORTUNITIES TO 2645 02:03:05,696 --> 02:03:16,073 CLINICIAN SCIENTISTS. 2646 02:03:20,845 --> 02:03:22,446 >> WAS THERE A DISCUSSION AROUND 2647 02:03:22,446 --> 02:03:23,881 COVERING PATIENTS THAT ARE 2648 02:03:23,881 --> 02:03:30,721 RESEARCH RELATED TO ENSURE AND 2649 02:03:30,721 --> 02:03:33,357 GETTING WHAT THEY KNEAD TO BE 2650 02:03:33,357 --> 02:03:35,526 SUCCESSFUL -- NEED TO BE 2651 02:03:35,526 --> 02:03:39,897 SUCCESSFUL BUT EVEN THAT TIME IN 2652 02:03:39,897 --> 02:03:41,665 THE CLINIC THERE'S THE 2653 02:03:41,665 --> 02:03:45,136 OPPORTUNITY TO SEE PATIENTS THAT 2654 02:03:45,136 --> 02:03:50,808 MOVE THE RESEARCH FORWARD AND 2655 02:03:50,808 --> 02:03:53,911 WANTED TO MAKE A COMMENT THE 2656 02:03:53,911 --> 02:03:55,513 FOUNDATION FOR NIH IS AN OFFICE 2657 02:03:55,513 --> 02:03:59,784 THAT DOES EXIST TO HELP BROKER 2658 02:03:59,784 --> 02:04:02,186 RELATIONSHIPS WITH INDUSTRY AND 2659 02:04:02,186 --> 02:04:03,354 WITH PROFESSIONAL SOCIETIES TO 2660 02:04:03,354 --> 02:04:11,896 ENSURE THERE'S NO CONFLICT OF 2661 02:04:11,896 --> 02:04:12,163 INTEREST. 2662 02:04:12,163 --> 02:04:15,599 AND THESE SOCIETIES AND FNIH 2663 02:04:15,599 --> 02:04:16,801 THERE'S A MECHANISM THAT 2664 02:04:16,801 --> 02:04:18,235 CURRENTLY EXISTS TO ENSURE THE 2665 02:04:18,235 --> 02:04:28,646 RELATIONSHIPS CAN OCCUR. 2666 02:04:29,113 --> 02:04:30,848 THE POINT BROUGHT UP FREQUENTLY 2667 02:04:30,848 --> 02:04:35,119 IS LET'S TAKE THE LAST EXAMPLE. 2668 02:04:35,119 --> 02:04:37,154 AND WANT TO DEVELOP A PROGRAM 2669 02:04:37,154 --> 02:04:43,461 WITH NIDCR, WHO DO THEY CONTACT? 2670 02:04:43,461 --> 02:04:47,898 I THINK AND THERE'S FRUSTRATION 2671 02:04:47,898 --> 02:04:51,001 INSOFAR AS THE PROFESSIONAL 2672 02:04:51,001 --> 02:04:52,503 AGENCIES KNOW THEY CAN'T DO IT 2673 02:04:52,503 --> 02:04:54,071 ALONE AND NEED NIDCR TO WORK 2674 02:04:54,071 --> 02:04:56,574 WITH THEM. 2675 02:04:56,574 --> 02:04:59,443 THERE'S THE ISSUE OF HOW DO YOU 2676 02:04:59,443 --> 02:04:59,977 PROVIDE OPPORTUNITIES FOR 2677 02:04:59,977 --> 02:05:07,852 CLINICIAN SCIENTISTS. 2678 02:05:07,852 --> 02:05:09,620 AND ONE WAY TO RETAIN AND 2679 02:05:09,620 --> 02:05:10,454 INTEREST THE CLINICIAN SCIENTIST 2680 02:05:10,454 --> 02:05:12,189 IS TO GIVE THEM A RESEARCH 2681 02:05:12,189 --> 02:05:19,230 OPPORTUNITY. 2682 02:05:19,230 --> 02:05:20,764 THEY DON'T KNOW THE NEXT STEP 2683 02:05:20,764 --> 02:05:22,800 AND ASKED ME TO TO DO THAT. 2684 02:05:22,800 --> 02:05:29,473 I'M NOT IN THAT POSITION. 2685 02:05:29,473 --> 02:05:32,309 AND YOU MENTIONED THAT OFFICE 2686 02:05:32,309 --> 02:05:34,211 BUT I WOULD NOT KNOW HOW TO 2687 02:05:34,211 --> 02:05:36,213 GUIDE SOMEBODY IF THE NEXT STEP 2688 02:05:36,213 --> 02:05:38,983 TO THAT OFFICE. 2689 02:05:38,983 --> 02:05:42,153 SO I THINK THAT'S WHY WE THOUGHT 2690 02:05:42,153 --> 02:05:44,488 THIS COULD BE A FULL-TIME JOB. 2691 02:05:44,488 --> 02:05:47,858 I KNOW THERE'S SOME RESTRICTIONS 2692 02:05:47,858 --> 02:05:49,193 ABOUT HAVING THE OFFICE WITHIN 2693 02:05:49,193 --> 02:05:52,129 NIDCR BUT HAVING AT LEAST A 2694 02:05:52,129 --> 02:05:55,166 PERSON WITH NIDCR WITH A CONTACT 2695 02:05:55,166 --> 02:05:58,469 WITH DIFFERENT PROGRAM OFFICERS 2696 02:05:58,469 --> 02:06:00,638 FACILITATE THESE INTERACTIONS IS 2697 02:06:00,638 --> 02:06:01,539 A CRITICAL STEP. 2698 02:06:01,539 --> 02:06:12,082 >> AND WE LOOK FORWARD TO THOSE 2699 02:06:12,650 --> 02:06:15,886 TYPES OF CLAN COLLABORATIONS 2700 02:06:15,886 --> 02:06:21,692 AND MOVING THAT FORWARD. 2701 02:06:21,692 --> 02:06:22,293 >> THANK YOU DANA AND YOUR XT 2702 02:06:22,293 --> 02:06:23,894 FOR THE THOUGHTFUL AND KRAEPTIVE 2703 02:06:23,894 --> 02:06:24,228 WORK. 2704 02:06:24,228 --> 02:06:25,196 I'M WONDERING ABOUT THE 2705 02:06:25,196 --> 02:06:25,763 FINANCIAL IMPACT. 2706 02:06:25,763 --> 02:06:31,902 IT MAY HAVE BEEN OUTSIDE OF YOUR 2707 02:06:31,902 --> 02:06:42,346 SCOPE AND THERE WOULD BE 2708 02:06:47,017 --> 02:06:47,885 STAFFING AND TRAVEL AND MAYBE 2709 02:06:47,885 --> 02:06:49,787 MORE THAN ONE PERSON. 2710 02:06:49,787 --> 02:06:51,889 WONDERING IF THAT CAME UP IN 2711 02:06:51,889 --> 02:06:54,491 YOUR DELIBERATIONS IN. 2712 02:06:54,491 --> 02:06:55,159 YOUR COMMITTEE. 2713 02:06:55,159 --> 02:06:57,061 >> I'M GLAD YOU MENTIONED THAT. 2714 02:06:57,061 --> 02:07:01,232 WE HAD AS ONE OF OUR GUIDING 2715 02:07:01,232 --> 02:07:03,334 UNDERLYING FACTORS THE CONCEPT 2716 02:07:03,334 --> 02:07:04,101 YOU CAN'T SIMPLY THROW MONEY AT 2717 02:07:04,101 --> 02:07:14,278 THE ISSUE. 2718 02:07:15,946 --> 02:07:19,883 THERE'S A COST AND NO FREE 2719 02:07:19,883 --> 02:07:23,554 LUNCH. 2720 02:07:23,554 --> 02:07:25,856 THERE'S MONEY SPENT ON RESEARCH 2721 02:07:25,856 --> 02:07:27,324 TRAINING AND THE IDEA OF 2722 02:07:27,324 --> 02:07:29,593 DEVELOPING A CENTER TO ANALYZE 2723 02:07:29,593 --> 02:07:29,793 THAT. 2724 02:07:29,793 --> 02:07:38,402 THE QUESTION IS THE MONEY WE 2725 02:07:38,402 --> 02:07:40,638 SPENT EFFICIENT AND EFFECTIVE. 2726 02:07:40,638 --> 02:07:42,239 IF THERE'S A GRANULAR ASSESSMENT 2727 02:07:42,239 --> 02:07:44,174 OF WHAT FACTORS LEAD TO SUCCESS 2728 02:07:44,174 --> 02:07:46,610 AND WHAT TYPES OF PROGRAMS LEAD 2729 02:07:46,610 --> 02:07:49,947 TO SUCCESS MAYBE IMPLEMENT A 2730 02:07:49,947 --> 02:07:51,482 GREATER VARIETY OF PROGRAMS THE 2731 02:07:51,482 --> 02:07:54,051 MONEY COULD BE USED MORE 2732 02:07:54,051 --> 02:07:55,286 EFFECTIVELY AND EFFICIENTLY. 2733 02:07:55,286 --> 02:07:59,890 I'M NOT SAYING IT CAN'T BE. 2734 02:07:59,890 --> 02:08:03,560 MAYBE THE WAY THINGS ARE NOW ARE 2735 02:08:03,560 --> 02:08:03,861 OPTIMAL. 2736 02:08:03,861 --> 02:08:11,635 I THINK HAVING A K AWARD WITH 2737 02:08:11,635 --> 02:08:14,071 40% PROTECTED RESEARCH TIME 2738 02:08:14,071 --> 02:08:17,007 WOULD REMOVE AN OBSTACLE TO 2739 02:08:17,007 --> 02:08:18,142 HIRING CLINICIAN SCIENTIST. 2740 02:08:18,142 --> 02:08:20,778 THIS IS MY PERSONAL VIEW POINT 2741 02:08:20,778 --> 02:08:23,881 NOT A COMMITTEE RECOMMENDATION. 2742 02:08:23,881 --> 02:08:26,083 DON'T GET MAD AT THE COMMITTEE 2743 02:08:26,083 --> 02:08:27,885 WORKING GROUP IF YOU DON'T LIKE 2744 02:08:27,885 --> 02:08:36,894 THAT. 2745 02:08:36,894 --> 02:08:38,595 >> ASKING ABOUT COST 2746 02:08:38,595 --> 02:08:39,863 EFFECTIVENESS OF COURSE WE DON'T 2747 02:08:39,863 --> 02:08:40,898 REALLY KNOW. 2748 02:08:40,898 --> 02:08:45,969 I THINK THOUGH IN THE 2749 02:08:45,969 --> 02:08:49,239 DISCUSSIONS WE HAD WITH LEADERS 2750 02:08:49,239 --> 02:08:51,875 OF SOCIETY AND THERE WAS SO MUCH 2751 02:08:51,875 --> 02:08:53,310 POSITIVITY TO THEM CONTRIBUTING 2752 02:08:53,310 --> 02:08:54,244 TO THESE TYPES OF EFFORTS. 2753 02:08:54,244 --> 02:08:56,714 IT WAS OVERWHELMING. 2754 02:08:56,714 --> 02:08:58,782 I THINK THERE'S A LOT TO BE 2755 02:08:58,782 --> 02:08:59,016 GAINED. 2756 02:08:59,016 --> 02:09:01,552 IT REMAINS TO BE SEEN BUT I 2757 02:09:01,552 --> 02:09:03,187 THINK THERE'S A LOT TO BE GAINED 2758 02:09:03,187 --> 02:09:05,489 IN TERMS OF RESOURCES AND 2759 02:09:05,489 --> 02:09:16,033 SUPPORTING CLINICIAN SCIENTISTS. 2760 02:09:16,734 --> 02:09:22,673 >> MICHELLE. 2761 02:09:22,673 --> 02:09:25,976 >> THANK YOU FOR PUTTING THIS 2762 02:09:25,976 --> 02:09:27,678 TOGETHER AND THE PRESSING NEED 2763 02:09:27,678 --> 02:09:29,380 FOR FUTURE GENERATIONS. 2764 02:09:29,380 --> 02:09:35,486 A QUESTION I HAVE TWO QUESTIONS. 2765 02:09:35,486 --> 02:09:40,491 GOING BACK TO WHAT WAS MENTIONED 2766 02:09:40,491 --> 02:09:45,662 EARLIER, I STILL DON'T THINK WE 2767 02:09:45,662 --> 02:09:51,902 HAVE A SOLUTION. 2768 02:09:51,902 --> 02:09:54,238 THEY ARE CARRY AN ENORMOUS 2769 02:09:54,238 --> 02:09:56,306 AMOUNT OF DEBT AND THE STIPEND 2770 02:09:56,306 --> 02:09:59,476 IS NOT COMPETITIVE. 2771 02:09:59,476 --> 02:10:00,711 ARE YOU PROPOSING NIDCR MAYBE 2772 02:10:00,711 --> 02:10:06,083 NEED TO INCREASE THE STIPEND 2773 02:10:06,083 --> 02:10:07,985 THAT WILL BE SUPPORTED OR MAKING 2774 02:10:07,985 --> 02:10:10,354 SURE THEY REMAIN COMPETITIVE IN 2775 02:10:10,354 --> 02:10:14,425 TERMS OF THEIR STIPEND? 2776 02:10:14,425 --> 02:10:19,396 WE'RE RUNNING INTO PROGRAMS WE 2777 02:10:19,396 --> 02:10:20,731 OFTEN HEAR -- WE SAID WE'LL DO 2778 02:10:20,731 --> 02:10:23,901 RESEARCH BUT AT THE END OF THE 2779 02:10:23,901 --> 02:10:27,905 DAY I'M RAISING A FAMILY. 2780 02:10:27,905 --> 02:10:32,109 A STIPEND BECOMES AN ISSUE. 2781 02:10:32,109 --> 02:10:34,845 I'M NOT SURE WHAT IS A PROPOSAL 2782 02:10:34,845 --> 02:10:37,614 AND A TWO-WAY PROCESS AND COMING 2783 02:10:37,614 --> 02:10:38,215 FROM INDUSTRY OR INSTITUTION 2784 02:10:38,215 --> 02:10:43,620 RECRUITING. 2785 02:10:43,620 --> 02:10:51,028 THAT'S ONE QUESTION FOR THE 2786 02:10:51,028 --> 02:10:51,562 COMMITTEE. 2787 02:10:51,562 --> 02:10:54,631 >> IN TERMS OF THE STIPEND, 2788 02:10:54,631 --> 02:10:56,967 THAT'S NOT THE FEEDBACK WE 2789 02:10:56,967 --> 02:10:59,203 GENERALLY GOT FROM THE TRAINEES. 2790 02:10:59,203 --> 02:11:02,306 WHAT WE GOT FROM THE TRAINEES IS 2791 02:11:02,306 --> 02:11:03,907 THAT THEY DON'T HAVE ENOUGH 2792 02:11:03,907 --> 02:11:05,776 AVAILABLE POSITIONS TO GO INTO 2793 02:11:05,776 --> 02:11:07,878 AND HAVE A RESEARCH COMPONENT. 2794 02:11:07,878 --> 02:11:14,318 SO IT WAS MORE THE STRUCTURE 2795 02:11:14,318 --> 02:11:20,424 DURING THIS TRANSITION. 2796 02:11:20,424 --> 02:11:29,900 THE COMMITTEE FOCUSSED MORE ON 2797 02:11:29,900 --> 02:11:30,267 L 2798 02:11:30,267 --> 02:11:31,668 LOAN REPAYMENT PROGRAMS AND 2799 02:11:31,668 --> 02:11:35,873 ESTABLISH FACULTY POSITIONS THAT 2800 02:11:35,873 --> 02:11:37,708 ALLOW MORE RESEARCH OPPORTUNITY. 2801 02:11:37,708 --> 02:11:41,578 WE DID NOT GET A LOT OF FEEDBACK 2802 02:11:41,578 --> 02:11:45,549 OF THE STIPENDS PER SE WERE TOO 2803 02:11:45,549 --> 02:11:45,849 LOW. 2804 02:11:45,849 --> 02:11:49,887 >> MAYBE WE SHOULD CLARIFY IN 2805 02:11:49,887 --> 02:11:51,889 TALKING ABOUT THE STIPENDS FOR 2806 02:11:51,889 --> 02:11:57,561 TRAINEES AT THE PREDOC OR 2807 02:11:57,561 --> 02:11:58,228 POSTDOC LEVEL. 2808 02:11:58,228 --> 02:11:59,897 >> THANK YOU, THAT'S A GOOD 2809 02:11:59,897 --> 02:12:01,398 POINT. 2810 02:12:01,398 --> 02:12:04,101 MENTIONED MORE AFTER THE 2811 02:12:04,101 --> 02:12:07,571 TRAINING PROGRAM. 2812 02:12:07,571 --> 02:12:15,746 THEY'RE NOW GOING TO FACULTY 2813 02:12:15,746 --> 02:12:16,680 POSITION. 2814 02:12:16,680 --> 02:12:20,317 >> SO EVEN A BIGGER ISSUE THAN 2815 02:12:20,317 --> 02:12:26,456 SALARY WAS THE LOAN 2816 02:12:26,456 --> 02:12:27,090 INDEBTEDNESS. 2817 02:12:27,090 --> 02:12:28,559 THE LOAN REPAYMENT PROGRAMS WE 2818 02:12:28,559 --> 02:12:32,296 THOUGHT PLAY BE A MORE COST 2819 02:12:32,296 --> 02:12:36,667 EFFECTIVE WAY OF APPROACHING 2820 02:12:36,667 --> 02:12:37,134 THIS. 2821 02:12:37,134 --> 02:12:40,270 THE WORKING GROUP MEMBERS WANTED 2822 02:12:40,270 --> 02:12:43,073 TO TIE THE LOAN REPAYMENT 2823 02:12:43,073 --> 02:12:46,209 PROGRAM TO YEARS IN ACADEMICS. 2824 02:12:46,209 --> 02:12:48,779 SO THERE WAS SOME CONCERN THAT 2825 02:12:48,779 --> 02:12:52,382 IF THE LOAN REPAYMENT SAY IT WAS 2826 02:12:52,382 --> 02:12:54,284 SUBSTANTIAL IN TWO YEARS ON YEAR 2827 02:12:54,284 --> 02:12:55,485 THREE THEY'LL LEAVE ACADEMICS 2828 02:12:55,485 --> 02:12:58,655 BECAUSE THE INCENTIVE IS GONE. 2829 02:12:58,655 --> 02:13:02,859 THERE WAS SOME THOUGHT OF HOW DO 2830 02:13:02,859 --> 02:13:07,898 YOU TIE IT TO A REAL COMMITMENT 2831 02:13:07,898 --> 02:13:09,900 TO ACADEMICS AND SOMETHING NIDCR 2832 02:13:09,900 --> 02:13:11,368 WOULD HAVE TO SORT OUT. 2833 02:13:11,368 --> 02:13:19,810 I WOULD SAY THE SALARIES ARE AN 2834 02:13:19,810 --> 02:13:28,819 ISSUE THAT WAS TIED TO THE LOAN 2835 02:13:28,819 --> 02:13:29,152 INDEBTEDNESS. 2836 02:13:29,152 --> 02:13:32,889 THE PROFESSIONAL SOCIETIES 2837 02:13:32,889 --> 02:13:36,927 INDICATED A WILLINGNESS FOR 2838 02:13:36,927 --> 02:13:37,661 SALARY SUPPORT IF COMBINING 2839 02:13:37,661 --> 02:13:39,896 PROGRAMS AND SOMETHING I 2840 02:13:39,896 --> 02:13:41,698 PERSONALLY WOULD BE SOMETHING 2841 02:13:41,698 --> 02:13:45,135 WORTH CONSIDERING IS TO DO A 2842 02:13:45,135 --> 02:13:47,971 40-20-40 TYPE OF SPLIT WHERE 2843 02:13:47,971 --> 02:13:54,111 NIDCR MIGHT FUND PART OF THE 2844 02:13:54,111 --> 02:13:57,447 RESEARCH COMPONENT PROFESSIONAL 2845 02:13:57,447 --> 02:13:58,915 SOCIETIES WOULD FUND A CLINICIAN 2846 02:13:58,915 --> 02:14:03,987 WHO DOES RESEARCH BUT FUND PART 2847 02:14:03,987 --> 02:14:10,527 OF THE TEACHING COMPONENT. 2848 02:14:10,527 --> 02:14:12,396 YOU CAN HAVE CLINICIAN 2849 02:14:12,396 --> 02:14:13,096 EDUCATORS. 2850 02:14:13,096 --> 02:14:18,035 I THINK RETHINKING SOME OF THE 2851 02:14:18,035 --> 02:14:21,204 PROGRAMS DEVELOPING PARTNERSHIPS 2852 02:14:21,204 --> 02:14:23,206 AND CREATIVE LOAN REPAYMENT 2853 02:14:23,206 --> 02:14:25,942 PROGRAM CAN GO A LONG WAY 2854 02:14:25,942 --> 02:14:28,745 TOWARDS INCREASING THE NUMBER OF 2855 02:14:28,745 --> 02:14:30,280 POSITIONS THAT ARE AVAILABLE FOR 2856 02:14:30,280 --> 02:14:31,882 CLINICIAN SCIENTISTS. 2857 02:14:31,882 --> 02:14:35,886 ONE OF THE THINGS I SHOULD 2858 02:14:35,886 --> 02:14:38,522 EMPHASIZE THE PEOPLE ONES WHO 2859 02:14:38,522 --> 02:14:39,523 COULD GO INTO RESEARCH LOVE 2860 02:14:39,523 --> 02:14:40,023 THEIR PROGRAMS. 2861 02:14:40,023 --> 02:14:44,728 IT WASN'T LIKE THE PROGRAMS WERE 2862 02:14:44,728 --> 02:14:44,895 BAD. 2863 02:14:44,895 --> 02:14:47,898 IT WAS THAT THE POSITIONS THEY 2864 02:14:47,898 --> 02:14:50,367 WERE OFFERED FOCUSSED ON 2865 02:14:50,367 --> 02:14:51,935 TEACHING AND HAD SMALL RESEARCH 2866 02:14:51,935 --> 02:14:53,370 OPPORTUNITY AND THOUGHT I SPENT 2867 02:14:53,370 --> 02:14:55,572 ALL THIS TIME LEARNING HOW TO DO 2868 02:14:55,572 --> 02:14:56,940 RESEARCH I WANT TO DO RESEARCH 2869 02:14:56,940 --> 02:14:58,508 BUT THE DENTAL SCHOOLS DON'T 2870 02:14:58,508 --> 02:15:02,579 GIVE ME THAT OPPORTUNITY. 2871 02:15:02,579 --> 02:15:10,353 THANK YOU, DANA. 2872 02:15:10,353 --> 02:15:12,823 >> YOU CAN OBTAIN THE DUAL 2873 02:15:12,823 --> 02:15:17,694 DEGREE AND THEN LEFT AND WENT TO 2874 02:15:17,694 --> 02:15:22,699 PRIVATE PRACTICE THEY COULD NOT 2875 02:15:22,699 --> 02:15:25,102 FIND THE RIGHT POSITION WITH 2876 02:15:25,102 --> 02:15:26,803 PROTECTED TIME TO DO RESEARCH 2877 02:15:26,803 --> 02:15:28,438 AND WERE FACED WITH THE 2878 02:15:28,438 --> 02:15:31,341 OPPORTUNITY OF HAVING A CLINICAL 2879 02:15:31,341 --> 02:15:32,008 TEACHING, ACADEMIC POSITION AND 2880 02:15:32,008 --> 02:15:35,879 WHEN THEY LOOKED AT THAT, THEY 2881 02:15:35,879 --> 02:15:38,582 CONSIDERED PRIVATE PRACTICE AS A 2882 02:15:38,582 --> 02:15:39,916 BETTER CHOICE AND BETTER 2883 02:15:39,916 --> 02:15:41,384 FINANCIAL COMPENSATION AND 2884 02:15:41,384 --> 02:15:43,887 EITHER WAY THEY WEREN'T GOING TO 2885 02:15:43,887 --> 02:15:51,061 GET TO DO WHAT THAT WANTED TO DO 2886 02:15:51,061 --> 02:15:53,897 AND PROVIDING A STRUCTURE FOR 2887 02:15:53,897 --> 02:15:55,665 PROTECTED TIME WOULD PROVIDE THE 2888 02:15:55,665 --> 02:15:56,166 POSITIONS FOR MANY MORE 2889 02:15:56,166 --> 02:16:01,938 TRAINEES. 2890 02:16:01,938 --> 02:16:07,878 >> AND TO AMPLIFY WHAT LOUIS 2891 02:16:07,878 --> 02:16:13,083 SAID IS THE IDEA OF RESEARCH IS 2892 02:16:13,083 --> 02:16:14,951 APPEALING AND THERE MAY NOT BE A 2893 02:16:14,951 --> 02:16:17,454 LARGE NUMBER THAT WANT TO DO 2894 02:16:17,454 --> 02:16:18,755 RESEARCH BUT THERE'S ENOUGH. 2895 02:16:18,755 --> 02:16:20,824 IT SEEMS FROM THE WORKING GROUP 2896 02:16:20,824 --> 02:16:22,793 PERSPECTIVE THERE'S MORE 2897 02:16:22,793 --> 02:16:23,927 INTERESTED IN DOING RESEARCH 2898 02:16:23,927 --> 02:16:25,495 THAN THERE ARE REAL RESEARCH 2899 02:16:25,495 --> 02:16:34,838 POSITIONS AVAILABLE TO THEM. 2900 02:16:34,838 --> 02:16:36,940 >> COULD YOU ADDRESS DENTAL 2901 02:16:36,940 --> 02:16:42,279 SCHOOLS' POSITIONS ON THIS. 2902 02:16:42,279 --> 02:16:43,380 >> THE POSITION UNDER LIES A LOT 2903 02:16:43,380 --> 02:16:51,288 OF THE COMMENTS I MADE WHICH IS 2904 02:16:51,288 --> 02:16:58,028 THERE'S A COMPETITION AND THERE 2905 02:16:58,028 --> 02:17:03,633 ARE FEWER FACULTY MEMBERS 2906 02:17:03,633 --> 02:17:03,900 AVAILABLE. 2907 02:17:03,900 --> 02:17:07,871 IT BECOMES EXPENSIVE AND HU DO 2908 02:17:07,871 --> 02:17:18,281 YOU PAY A DENTIST TO TEACH AND 2909 02:17:18,281 --> 02:17:20,417 SCHOOL AND SALARIES ARE TIED TO 2910 02:17:20,417 --> 02:17:21,918 TUITION. 2911 02:17:21,918 --> 02:17:25,555 WHO IS GOING TO PAY TO DO 2912 02:17:25,555 --> 02:17:36,099 RESEARCH 30% OR 40% OF THE TIME? 2913 02:17:41,705 --> 02:17:43,874 THE MARRIAGE OF A CLINICIAN THAT 2914 02:17:43,874 --> 02:17:45,175 DOES TEACHING AND RESEARCH THERE 2915 02:17:45,175 --> 02:17:50,480 AREN'T THAT MANY AF NOW'S FOR 2916 02:17:50,480 --> 02:17:53,350 DENTAL SCHOOLS AND THEY RAISE 2917 02:17:53,350 --> 02:17:55,252 THE QUESTION HOW TO ACHIEVE THIS 2918 02:17:55,252 --> 02:18:01,024 BECAUSE CURRENT MECHANISMS TO 2919 02:18:01,024 --> 02:18:02,125 ACHIEVE A CLINICIAN SCIENTIST 2920 02:18:02,125 --> 02:18:03,894 WHO SPENDS 40% OF THEIR TIME 2921 02:18:03,894 --> 02:18:06,296 TEACHING AND DOING RESEARCH IS A 2922 02:18:06,296 --> 02:18:12,302 DIFFICULT PROPOSITION. 2923 02:18:12,302 --> 02:18:14,104 THEY DON'T HAVE A WAY TO FUND 2924 02:18:14,104 --> 02:18:16,072 THE RESEARCH AND THE GRANT 2925 02:18:16,072 --> 02:18:18,308 MECHANISM IS NOT NECESSARILY 2926 02:18:18,308 --> 02:18:27,817 FRIENDLY TO THAT. 2927 02:18:27,817 --> 02:18:31,321 >> DO YOU THINK I RELAYED THAT 2928 02:18:31,321 --> 02:18:34,057 ACCURATELY OR ARE THERE OTHER 2929 02:18:34,057 --> 02:18:39,863 CONCERNS YOU PLAY HAVE? 2930 02:18:39,863 --> 02:18:42,299 >> I AGREE. 2931 02:18:42,299 --> 02:18:45,001 IT'S NOT QUITE AS SIMPLE BECAUSE 2932 02:18:45,001 --> 02:18:48,104 THERE ARE A RANGE OF TYPE OF 2933 02:18:48,104 --> 02:18:49,873 DENTAL SCHOOLS TOO. 2934 02:18:49,873 --> 02:18:53,043 A DENTAL SCHOOL LIKE YOU'RE IN 2935 02:18:53,043 --> 02:18:58,882 OR I'M IN OR JACQUES IS IN 2936 02:18:58,882 --> 02:18:59,716 VALUES THAT. 2937 02:18:59,716 --> 02:19:01,151 WE CARVE OUT THE SPACE AND TIME 2938 02:19:01,151 --> 02:19:02,986 AND FIGURE OUT A WAY TO DO IT. 2939 02:19:02,986 --> 02:19:06,122 THE MAJORITY OF THE DENTAL 2940 02:19:06,122 --> 02:19:11,261 SCHOOLS ARE NOT IN THE SAME 2941 02:19:11,261 --> 02:19:13,463 POSITION AND AND NOT EVEN AT A 2942 02:19:13,463 --> 02:19:15,065 UNIVERSITY THAT VALUES IT. 2943 02:19:15,065 --> 02:19:16,566 YOU NEED A UNIVERSITY OR SCHOOL 2944 02:19:16,566 --> 02:19:18,301 THAT VALUES IT AND A LEADER THAT 2945 02:19:18,301 --> 02:19:19,869 VALUES IT AND THEN THEY CAN MAKE 2946 02:19:19,869 --> 02:19:23,873 IT WORK BUT IT'S STILL A 2947 02:19:23,873 --> 02:19:27,877 STRUGGLE. 2948 02:19:27,877 --> 02:19:31,881 >> 2949 02:19:31,881 --> 02:19:36,152 >> YOU HAVE TROUBLE GIVING ALL 2950 02:19:36,152 --> 02:19:39,255 THE CLINICIANS WHO WANT TO DO 2951 02:19:39,255 --> 02:19:43,860 RESEARCH THAT OPPORTUNITIES. 2952 02:19:43,860 --> 02:19:46,930 I WOULD SAY THAT'S STILL A 2953 02:19:46,930 --> 02:19:52,569 STRUGGLE FOR SCHOOLS LIKE PENN. 2954 02:19:52,569 --> 02:19:54,304 YOU HAVE TENURE TRACK FACULTY 2955 02:19:54,304 --> 02:20:00,310 WHO DO RESEARCH AND CLINICAL 2956 02:20:00,310 --> 02:20:01,945 FACULTY WHO WANT TO DO MORE 2957 02:20:01,945 --> 02:20:03,880 RESEARCH BUT THE SCHOOLS CAN'T 2958 02:20:03,880 --> 02:20:05,882 AFFORD TO LET THEM DO THAT AND 2959 02:20:05,882 --> 02:20:07,650 TALKING ABOUT THAT CADRE OF 2960 02:20:07,650 --> 02:20:08,385 CLINICAL FACULTY. 2961 02:20:08,385 --> 02:20:12,422 >> I THINK WE COULD HAVE 2962 02:20:12,422 --> 02:20:13,923 CLINICAL FACULTY THAT SPENT A 2963 02:20:13,923 --> 02:20:15,892 MORE SIGNIFICANT TIME DOING 2964 02:20:15,892 --> 02:20:23,867 RESEARCH THAN WE CURRENTLY DO 2965 02:20:23,867 --> 02:20:26,970 AND HAVE TO ATTRACT AND BE 2966 02:20:26,970 --> 02:20:27,604 AWARDED SUBSTANTIAL FUNDING TO 2967 02:20:27,604 --> 02:20:33,576 DO IT AS WELL. 2968 02:20:33,576 --> 02:20:36,846 AND HAVE CLINICIANS WHO DO 40% 2969 02:20:36,846 --> 02:20:38,581 RESEARCH AND PUBLISH A PAPER 2970 02:20:38,581 --> 02:20:40,984 ONCE A YEAR OR SOMETHING WITHOUT 2971 02:20:40,984 --> 02:20:43,887 BRINGING THEIR FUNDING TO HELP 2972 02:20:43,887 --> 02:20:45,422 SUPPORT THAT. 2973 02:20:45,422 --> 02:20:46,389 THAT'S WHERE IT'S THE GRAY ZONE 2974 02:20:46,389 --> 02:20:51,161 IS TOUGH. 2975 02:20:51,161 --> 02:20:55,899 THE WORKING GROUP IS SUGGESTING 2976 02:20:55,899 --> 02:20:56,633 DIFFERENT WAYS YOU CAN APPROACH 2977 02:20:56,633 --> 02:21:01,671 THAT PROBLEM. 2978 02:21:01,671 --> 02:21:02,906 I MENTIONED ONE SPECIFIC EXAMPLE 2979 02:21:02,906 --> 02:21:13,416 WHERE THE K AWARDS LIMIT THAT. 2980 02:21:14,851 --> 02:21:16,152 THERE'S MULTIPLE WAYS THIS COULD 2981 02:21:16,152 --> 02:21:19,889 BE APPROACHED BUT I THINK THERE 2982 02:21:19,889 --> 02:21:22,592 IS A STRONG FEELING THAT 2983 02:21:22,592 --> 02:21:24,527 PARTNERSHIP AND RETHINKING SOME 2984 02:21:24,527 --> 02:21:25,762 OF THE TYPES OF TRAINING 2985 02:21:25,762 --> 02:21:27,897 PROGRAMS THAT EXIST WOULD BE 2986 02:21:27,897 --> 02:21:30,266 PRODUCTIVE. 2987 02:21:30,266 --> 02:21:32,569 >> ALL GREAT IDEAS. 2988 02:21:32,569 --> 02:21:36,873 >> ONE POINT, WE'RE STILL IN THE 2989 02:21:36,873 --> 02:21:38,675 CONUNDRUM BECAUSE THEY WANT TO 2990 02:21:38,675 --> 02:21:41,311 DO RESEARCH AND SCHOOLS ARE 2991 02:21:41,311 --> 02:21:43,746 WILLING TO PROVIDE SPACE AND 2992 02:21:43,746 --> 02:21:47,884 OPPORTUNITIES FOR THEM BUT THAT 2993 02:21:47,884 --> 02:21:51,087 COMES WITH A CATCH 22. 2994 02:21:51,087 --> 02:21:56,759 THEY NEED TO HAVE FUNDING TO DO 2995 02:21:56,759 --> 02:22:01,865 THEIR RESEARCH TO BE A CLINICIAN 2996 02:22:01,865 --> 02:22:02,298 SCIENTIST. 2997 02:22:02,298 --> 02:22:03,867 TO ME THAT'S A CONUNDRUM THAT 2998 02:22:03,867 --> 02:22:05,068 NEEDS TO BE RESOLVED. 2999 02:22:05,068 --> 02:22:15,411 I KNOW DANA IN YOUR PRESENTATION 3000 02:22:15,411 --> 02:22:22,886 YOU'RE PROPOSING MODELS AND 3001 02:22:22,886 --> 02:22:23,253 SUSTAINABILITY. 3002 02:22:23,253 --> 02:22:24,921 AND MAKE SURE THEY'RE SUCCESSFUL 3003 02:22:24,921 --> 02:22:26,823 FOR A LONG PERIOD OF TIME. 3004 02:22:26,823 --> 02:22:29,225 IT LOOKS LIKE THEY ARE NEED TO 3005 02:22:29,225 --> 02:22:30,827 HAVE SOME TYPE OF NEW GRANT 3006 02:22:30,827 --> 02:22:34,230 MECHANISM COMING FROM K'S OR 3007 02:22:34,230 --> 02:22:35,899 TRAINING PROGRAMS OR CLINICIAN 3008 02:22:35,899 --> 02:22:38,001 SCIENTISTS HAVE THE ABILITY TO 3009 02:22:38,001 --> 02:22:38,601 SECURE FUNDING AND FOR LONGER 3010 02:22:38,601 --> 02:22:42,839 PERIOD OF TIME. 3011 02:22:42,839 --> 02:22:47,744 CAN WE DISCUSS THE 3012 02:22:47,744 --> 02:22:48,378 RECOMMENDATIONS FROM THE 3013 02:22:48,378 --> 02:22:51,381 COMMITTEE ON THE CONUNDRUM. 3014 02:22:51,381 --> 02:22:55,652 >> THAT'S THE RECOMMENDATION TO 3015 02:22:55,652 --> 02:22:58,688 DEVELOP NEW GRANT MECHANISMS 3016 02:22:58,688 --> 02:23:01,658 WITH CLINICIAN SCIENTISTS IN 3017 02:23:01,658 --> 02:23:01,858 MIND. 3018 02:23:01,858 --> 02:23:03,893 THE CURRENT MECHANISM ARE VERY 3019 02:23:03,893 --> 02:23:05,828 MUCH TAILORED TO TENURE TRACK 3020 02:23:05,828 --> 02:23:06,563 FACULTY WHO ARE FULL-TIME 3021 02:23:06,563 --> 02:23:09,065 RESEARCHERS. 3022 02:23:09,065 --> 02:23:15,471 THAT IS VERY SIMPLY THE 3023 02:23:15,471 --> 02:23:15,872 RECOMMENDATION. 3024 02:23:15,872 --> 02:23:17,140 >> QUICK QUESTION DOES THE 3025 02:23:17,140 --> 02:23:21,077 COMMITTEE TALK ABOUT THE TIME 3026 02:23:21,077 --> 02:23:22,812 PERCENTAGES? 3027 02:23:22,812 --> 02:23:23,813 DOES THE COMMITTEE BELIEVE 40% 3028 02:23:23,813 --> 02:23:29,419 TIME IS ENOUGH TO BE 3029 02:23:29,419 --> 02:23:32,555 COMPETITIVE? 3030 02:23:32,555 --> 02:23:35,091 >> I THINK THERE'S NO MAGIC 3031 02:23:35,091 --> 02:23:41,564 NUMBER BUT 40% IS A NUMBER THE 3032 02:23:41,564 --> 02:23:44,167 WORKING GROUP BROUGHT UP AND 3033 02:23:44,167 --> 02:23:47,070 WITH WAS BROUGHT UP AS 40% AS A 3034 02:23:47,070 --> 02:23:47,503 REASONABLE TARGET. 3035 02:23:47,503 --> 02:23:48,771 I THROW THAT OUT BECAUSE I 3036 02:23:48,771 --> 02:23:52,408 REMEMBER FROM THE LISTENING 3037 02:23:52,408 --> 02:23:56,246 SESSION BUT THIS MIGHT BE 3038 02:23:56,246 --> 02:23:59,649 SOMETHING THAT EVOLVES AND NIDCR 3039 02:23:59,649 --> 02:24:03,886 HAS DIFFERENT TARGETS TO SEE 3040 02:24:03,886 --> 02:24:06,422 WHICH IS SUCCESSFUL. 3041 02:24:06,422 --> 02:24:11,894 THE PROBLEM IS IN MOST SCHOOLS 3042 02:24:11,894 --> 02:24:15,665 I'VE FAMILIAR WITH THE STANDARD 3043 02:24:15,665 --> 02:24:16,699 RESEARCH TIME FOR CLINICIAN 3044 02:24:16,699 --> 02:24:18,401 EDUCATORS IS 20%. 3045 02:24:18,401 --> 02:24:23,873 I THINK IT'S THOUGHT THAT IS NOT 3046 02:24:23,873 --> 02:24:24,674 SUSTAINABLE. 3047 02:24:24,674 --> 02:24:27,176 IT'S HARD TO REALLY LEAD A 3048 02:24:27,176 --> 02:24:28,878 PROGRAM IN 20% TIME. 3049 02:24:28,878 --> 02:24:31,814 TWO DAYS A WEEK I THINK THERE IS 3050 02:24:31,814 --> 02:24:35,485 A FEELING THAT THAT IS 3051 02:24:35,485 --> 02:24:35,785 SUFFICIENT. 3052 02:24:35,785 --> 02:24:37,787 I THINK THERE'S A LOT OF 3053 02:24:37,787 --> 02:24:39,255 CLINICIAN SCIENTISTS IN MEDICINE 3054 02:24:39,255 --> 02:24:41,424 THAT SPEND 40% TO 50% OF THEIR 3055 02:24:41,424 --> 02:24:49,165 TIME IN RESEARCH AND 40% TO 50% 3056 02:24:49,165 --> 02:24:50,833 IN TEACHING. 3057 02:24:50,833 --> 02:25:01,344 IT'S A GOAL WORTH ATTEMPTING. 3058 02:25:02,578 --> 02:25:09,319 >> WE'RE RUNNING SHORT ON TIME. 3059 02:25:09,319 --> 02:25:11,888 >> I WOULD SAY I DON'T KNOW WHAT 3060 02:25:11,888 --> 02:25:13,356 THE NUMBER OR PERCENT WOULD NEED 3061 02:25:13,356 --> 02:25:16,693 TO BE TO MAKE A SUCCESSFUL 3062 02:25:16,693 --> 02:25:16,926 EITHER. 3063 02:25:16,926 --> 02:25:21,998 HOWEVER, I WOULD SAY THAT IF 3064 02:25:21,998 --> 02:25:22,799 SOMEONE HAD STRONG TRAINING AND 3065 02:25:22,799 --> 02:25:28,571 WERE IN A SUPPORTIVE ENVIRONMENT 3066 02:25:28,571 --> 02:25:31,774 WITH COLLEAGUES WHO WOULD WITH 3067 02:25:31,774 --> 02:25:33,176 LIKE-MINDED PEOPLE IN SUPPORT 3068 02:25:33,176 --> 02:25:35,611 SYSTEMS AND COLLABORATIONS COULD 3069 02:25:35,611 --> 02:25:36,379 BE DONE. 3070 02:25:36,379 --> 02:25:37,914 IF AN INDIVIDUAL IS AT A 3071 02:25:37,914 --> 02:25:39,382 DEPARTMENT OR SCHOOL WHERE 3072 02:25:39,382 --> 02:25:41,484 THERE'S NO SUPPORT STRUCTURE OR 3073 02:25:41,484 --> 02:25:43,619 NO LIKE-MINDED PEOPLE AROUND 3074 02:25:43,619 --> 02:25:51,894 THEM I THINK THE 40% MAY NOT 3075 02:25:51,894 --> 02:25:54,664 FLY. 3076 02:25:54,664 --> 02:25:57,700 >> A RESEARCH CENTER CAN PROVIDE 3077 02:25:57,700 --> 02:25:58,968 SUPPORT AND WOULD LIKE 3078 02:25:58,968 --> 02:25:59,869 CLINICIANS MORE INVOLVED IN THE 3079 02:25:59,869 --> 02:26:02,238 RESEARCH AND CAN PARTICIPATE 3080 02:26:02,238 --> 02:26:06,476 THAT IN THAT AT A 20% LEVEL IS 3081 02:26:06,476 --> 02:26:09,812 NOT QUITE ENOUGH. 3082 02:26:09,812 --> 02:26:13,182 >> LAST COMMENT FROM SHAWN. 3083 02:26:13,182 --> 02:26:14,784 >> I'LL BE BRIEF. 3084 02:26:14,784 --> 02:26:16,419 ONE OF THE ISSUES WITH K AWARDS 3085 02:26:16,419 --> 02:26:19,889 IS THERE'S NO THE A WHOLE LOT OF 3086 02:26:19,889 --> 02:26:23,893 SUPPORT TO DO THE RESEARCH 3087 02:26:23,893 --> 02:26:29,665 PROJECT ITSELF. 3088 02:26:29,665 --> 02:26:31,868 INCREASING SUPPORT IN TERMS OF 3089 02:26:31,868 --> 02:26:33,336 EFFORT IN THE PROJECT OF 40% 3090 02:26:33,336 --> 02:26:37,106 THERE PERHAPS COULD BE AN 3091 02:26:37,106 --> 02:26:39,342 OPPORTUNITY TO INCREASE A LITTLE 3092 02:26:39,342 --> 02:26:41,177 BIT THE SUPPORT TO INCREASE A 3093 02:26:41,177 --> 02:26:45,014 LITTLE BIT OF THE SUPPORT TO DO 3094 02:26:45,014 --> 02:26:47,016 THE PROJECT. 3095 02:26:47,016 --> 02:26:50,019 >> THANK YOU FOR MENTIONED THAT 3096 02:26:50,019 --> 02:26:53,623 WAS ONE OF THE RECOMMENDATIONS 3097 02:26:53,623 --> 02:26:54,424 BY REDUCING THE EFFORT YOU COULD 3098 02:26:54,424 --> 02:26:58,728 MAKE THAT POSSIBLE. 3099 02:26:58,728 --> 02:27:01,764 >> SO WHAT I'M HEARING IS THAT 3100 02:27:01,764 --> 02:27:04,834 IT TAKES COMMUNICATION BETWEEN 3101 02:27:04,834 --> 02:27:07,537 DENTAL SCHOOLS, PROFESSIONAL 3102 02:27:07,537 --> 02:27:09,939 SOCIETIES AND NIDCR NOT 3103 02:27:09,939 --> 02:27:10,773 NECESSARILY NIDCR WITH 3104 02:27:10,773 --> 02:27:15,778 PROFESSIONAL SOCIETIES AND OF 3105 02:27:15,778 --> 02:27:18,414 COURSE OTHER GROUPS ARE ALWAYS 3106 02:27:18,414 --> 02:27:19,882 ABLE TO PROVIDE FUNDING 3107 02:27:19,882 --> 02:27:20,683 INDEPENDENT OF NIDCR. 3108 02:27:20,683 --> 02:27:23,886 IT'S NOT AS THOUGH THEY HAVE TO 3109 02:27:23,886 --> 02:27:24,954 BE JOINT PROGRAMS. 3110 02:27:24,954 --> 02:27:27,890 JUST WANT TO POINT THAT OUT IT'S 3111 02:27:27,890 --> 02:27:31,194 EASIER TO BE INDEPENDENT. 3112 02:27:31,194 --> 02:27:35,865 I WOULD LIKE TO KNOW IF COUNCIL 3113 02:27:35,865 --> 02:27:37,266 CONCURS WITH THE RECOMMENDATIONS 3114 02:27:37,266 --> 02:27:38,935 OR IF YOU HAVE SUGGESTION OR 3115 02:27:38,935 --> 02:27:41,170 THINGS THAT SHOULD BE CONSIDERED 3116 02:27:41,170 --> 02:27:42,438 ADDITIONALLY BEFORE THERE ARE 3117 02:27:42,438 --> 02:27:52,448 FINALIZED RECOMMENDATIONS. 3118 02:27:52,448 --> 02:27:55,818 IF THERE'S SPECIFIC FEEDBACK OR 3119 02:27:55,818 --> 02:27:59,889 CONCURRENCE OR LACK OF 3120 02:27:59,889 --> 02:28:00,356 CONCURRENCE WITH THE 3121 02:28:00,356 --> 02:28:04,760 RECOMMENDATIONS. 3122 02:28:04,760 --> 02:28:06,729 >> I THINK THE COMMITTEE DID A 3123 02:28:06,729 --> 02:28:07,864 GREAT JOB. 3124 02:28:07,864 --> 02:28:11,734 IT'S NOT AN EASY NUT TO CRACK. 3125 02:28:11,734 --> 02:28:13,436 WE'VE THOUGHT ABOUT NIDCR AND 3126 02:28:13,436 --> 02:28:14,604 I'VE BEEN THINKING ABOUT THICK 3127 02:28:14,604 --> 02:28:16,806 THIS FOR MANY DECADES. 3128 02:28:16,806 --> 02:28:16,873 6: 3129 02:28:23,379 --> 02:28:30,219 I APPLAUD THE CREATIVITY. 3130 02:28:30,219 --> 02:28:33,623 IF WE NEED TO SIT HERE AND VOTE 3131 02:28:33,623 --> 02:28:34,690 IT'S A LITTLE HARD. 3132 02:28:34,690 --> 02:28:43,566 I VOTE WE TAKE THIS DEEPER. 3133 02:28:43,566 --> 02:28:47,870 I THINK IT NEEDS MORE DISCUSSION 3134 02:28:47,870 --> 02:28:54,343 AND WITH THE NIH AND NIDCR 3135 02:28:54,343 --> 02:28:55,878 LEADERSHIP AND WITH THE 3136 02:28:55,878 --> 02:28:57,780 COMMITTEE. 3137 02:28:57,780 --> 02:28:58,681 THERE'S A LOT THERE. 3138 02:28:58,681 --> 02:29:00,383 >> THE COMMITTEE DID AN AMAZING 3139 02:29:00,383 --> 02:29:03,019 JOB BUT THERE'S SO MANY NUANCES 3140 02:29:03,019 --> 02:29:12,061 THERE I FEEL WE NEED TO DISCUSS. 3141 02:29:12,061 --> 02:29:15,364 IT'S GOING TO SIT DIFFERENTLY IN 3142 02:29:15,364 --> 02:29:16,432 SCHOOLS AND DIFFERENT 3143 02:29:16,432 --> 02:29:17,567 INSTITUTIONS WILL BE DIFFERENT. 3144 02:29:17,567 --> 02:29:18,434 YOU NEED TO GET THE SUPPORT AS 3145 02:29:18,434 --> 02:29:23,673 WELL. 3146 02:29:23,673 --> 02:29:26,275 >> ARE THERE OTHER COUNCIL 3147 02:29:26,275 --> 02:29:27,877 MEMBERS CONCUR OR -- 3148 02:29:27,877 --> 02:29:34,317 >> I SECOND THAT. 3149 02:29:34,317 --> 02:29:38,154 >> THERE'S GREAT INITIAL EFFORT 3150 02:29:38,154 --> 02:29:41,924 BUT WE NEED TO GET TO THE 3151 02:29:41,924 --> 02:29:42,158 DETAILS. 3152 02:29:42,158 --> 02:29:47,263 THE DEVIL IS IN THE DETAILS. 3153 02:29:47,263 --> 02:29:49,699 GREAT EFFORT AND INITIATIVE BUT 3154 02:29:49,699 --> 02:29:51,867 SHOULD DIG IN TO FIND AN ETHICAL 3155 02:29:51,867 --> 02:29:52,768 ACTION ITEMS. 3156 02:29:52,768 --> 02:29:57,773 >> MAYBE WE CAN COME UP WITH 3157 02:29:57,773 --> 02:30:05,915 SPECIFIC THINGS TO MOVE FORWARD. 3158 02:30:05,915 --> 02:30:10,252 LOUISA. 3159 02:30:10,252 --> 02:30:20,763 >> WITH THE FULL REPORT IT'S 3160 02:30:26,369 --> 02:30:27,203 NIDCR'S DECISION AND IT WILL 3161 02:30:27,203 --> 02:30:28,904 DEPEND ON HOW THEY WANT TO USE 3162 02:30:28,904 --> 02:30:29,639 THEIR S TOO. 3163 02:30:29,639 --> 02:30:33,009 KEEP THAT IN MIND AS YOU REVIEW 3164 02:30:33,009 --> 02:30:34,343 THE RECOMMENDATIONS THAT THEY'RE 3165 02:30:34,343 --> 02:30:36,779 NOT ENTIRELY PRESCRIPTIVE ON HOW 3166 02:30:36,779 --> 02:30:37,780 SOMETHING COULD BE ACCOMPLISHED 3167 02:30:37,780 --> 02:30:40,182 AND WEREN'T ASKED TO DO THAT. 3168 02:30:40,182 --> 02:30:41,984 >> THANK YOU, THAT'S A VERY 3169 02:30:41,984 --> 02:30:45,054 IMPORTANT POINT. 3170 02:30:45,054 --> 02:30:46,422 THESE ARE RECOMMENDATIONS TO 3171 02:30:46,422 --> 02:30:51,861 COUNCIL AND YOU AGREE WITH WHAT 3172 02:30:51,861 --> 02:30:52,294 WAS DISCUSSED. 3173 02:30:52,294 --> 02:30:59,869 I HEAR A LOT OF AGREEMENT BUT 3174 02:30:59,869 --> 02:31:10,246 NOT NECESSARILY DETAILS. 3175 02:31:10,246 --> 02:31:11,881 AND WHAT NEED TO BE EXAMINED 3176 02:31:11,881 --> 02:31:17,353 WITH SUGGESTIONS. 3177 02:31:17,353 --> 02:31:18,621 DOES THAT CLARIFY? 3178 02:31:18,621 --> 02:31:22,658 OKAY. 3179 02:31:22,658 --> 02:31:23,125 OKAY. 3180 02:31:23,125 --> 02:31:24,326 THANK YOU VERY MUCH. 3181 02:31:24,326 --> 02:31:26,128 IF ANYBODY HAS ANY COMMENTS ON 3182 02:31:26,128 --> 02:31:27,863 THIS TOPIC SPECIFICALLY, PLEASE 3183 02:31:27,863 --> 02:31:33,636 FEEL FREE TO E-MAIL ME OR 3184 02:31:33,636 --> 02:31:35,871 DR. WEBB-CYRIAQUE AND WE HAVE A 3185 02:31:35,871 --> 02:31:37,173 GENERAL MAILBOX WE CAN TAKE MORE 3186 02:31:37,173 --> 02:31:39,241 COMMENTS FROM THE PUBLIC AND 3187 02:31:39,241 --> 02:31:40,710 PEOPLE WHO HAVE PARTICIPATED IN 3188 02:31:40,710 --> 02:31:41,944 THE MEETING TODAY. 3189 02:31:41,944 --> 02:31:47,883 IT'S TIME FOR OUR BREAK AND WE 3190 02:31:47,883 --> 02:31:51,887 WILL RETURN AT -- I'M FORGETTING 3191 02:31:51,887 --> 02:31:58,461 MY TIME, 1:15 TO BEGIN OUR THE 3192 02:31:58,461 --> 02:32:00,029 MINI SYMPOSIUM ON THE PROGRAM. 3193 02:32:00,029 --> 02:32:02,380 THANK YOU VERY MUCH. 3194 02:32:03,827 --> 02:32:08,231 >> WELCOME BACK EVERYONE TO THE 3195 02:32:08,231 --> 02:32:12,402 NIDCR COUNCIL MEETING. 3196 02:32:12,402 --> 02:32:19,309 I HOPE EVERYONE HAD A ROW -- 3197 02:32:19,309 --> 02:32:21,611 REFRESHING BREAK NEXT WE WILL 3198 02:32:21,611 --> 02:32:28,618 HAVE A MINI SYMPOSIUM ON THE AMP 3199 02:32:28,618 --> 02:32:29,619 AIM PROGRAM BY 3200 02:32:29,619 --> 02:32:30,821 DR. WEBB-CYRIAQUE. 3201 02:32:30,821 --> 02:32:33,123 >> IN LINE WITH OUR EARLIER 3202 02:32:33,123 --> 02:32:35,892 DISCUSSIONS, THE SECOND HALF OF 3203 02:32:35,892 --> 02:32:42,065 OUR OPEN COUNCIL SESSION WILL 3204 02:32:42,065 --> 02:32:42,833 FOCUS ON EXEMPLAR OF 3205 02:32:42,833 --> 02:32:49,473 PUBLIC-PRIVATE PARTNERSHIPS 3206 02:32:49,473 --> 02:32:51,308 DRIVING RESEARCH AND SCIENTISTS 3207 02:32:51,308 --> 02:32:53,477 LEADING THE. 3208 02:32:53,477 --> 02:32:58,882 -- INITIATIVE. 3209 02:32:58,882 --> 02:33:03,920 THIS IS OCCURRING IN THE CON TO 3210 02:33:03,920 --> 02:33:09,526 THE SJOGREN'S FOCUSSED 3211 02:33:09,526 --> 02:33:10,760 ACCELERATING PARTNERSHIP. 3212 02:33:10,760 --> 02:33:14,831 NEXT IN THE TRAINING OF 3213 02:33:14,831 --> 02:33:18,335 MENTORSHIP THE LEADERSHIP 3214 02:33:18,335 --> 02:33:19,870 SCHOLARS PROGRAM AND WE'LL END 3215 02:33:19,870 --> 02:33:21,304 THIS AFTERNOON WITH INNOVATIVE 3216 02:33:21,304 --> 02:33:23,907 INITIATIVES SHARED BY OUR 3217 02:33:23,907 --> 02:33:26,176 PROGRAM STAFF. 3218 02:33:26,176 --> 02:33:26,743 THEY'RE ALIGNED WITH OUR 3219 02:33:26,743 --> 02:33:30,213 STRATEGIC PRIORITIES. 3220 02:33:30,213 --> 02:33:32,749 SO, AROUND THE ACCELERATING 3221 02:33:32,749 --> 02:33:35,886 MEDICINES PARTNERSHIP THAT WE 3222 02:33:35,886 --> 02:33:38,822 CALL AMP, THIS IS FACILITATED BY 3223 02:33:38,822 --> 02:33:42,325 THE FOUNDATION OF NIH I 3224 02:33:42,325 --> 02:33:43,593 MENTIONED EARLIER TODAY. 3225 02:33:43,593 --> 02:33:46,463 THIS ACCELERATING MEDICINES 3226 02:33:46,463 --> 02:33:48,131 PARTNERSHIP TOGETHER WITH THE 3227 02:33:48,131 --> 02:33:50,534 AUTO IMMUNE AND IMMUNE-MEDIATED 3228 02:33:50,534 --> 02:33:59,709 DISEASES PROGRAM OR AMP AIM IS 3229 02:33:59,709 --> 02:34:02,746 PUBLIC-PRIVATE FOR VALIDATING 3230 02:34:02,746 --> 02:34:05,081 BIOLOGIC TARGETS FOCUSSED IN THE 3231 02:34:05,081 --> 02:34:06,483 AREA OF AUTO IMMUNE. 3232 02:34:06,483 --> 02:34:10,353 THIS WAS CREATED BACK IN 2014 AS 3233 02:34:10,353 --> 02:34:11,188 A COLLABORATIVE EFFORT BETWEEN 3234 02:34:11,188 --> 02:34:18,195 THE NIH, THE U.S. FOOD AND DRUG 3235 02:34:18,195 --> 02:34:19,162 ADMINISTRATION AND MULTIPLE 3236 02:34:19,162 --> 02:34:19,863 PHARMACEUTICAL AND LIFE SCIENCE 3237 02:34:19,863 --> 02:34:21,498 COMPANIES AND NON-PROFITS AND 3238 02:34:21,498 --> 02:34:23,867 OTHER ORGANIZATIONS TO TRANSFORM 3239 02:34:23,867 --> 02:34:26,736 THE CURRENT MODEL OF HOW WE 3240 02:34:26,736 --> 02:34:28,939 DEVELOP NEW DIAGNOSTICS AND 3241 02:34:28,939 --> 02:34:30,073 TREATMENTS. 3242 02:34:30,073 --> 02:34:32,909 TO THE DEARTH OF WHAT WAS 3243 02:34:32,909 --> 02:34:35,045 PREEXISTING TO TREAT AUTO IMMUNE 3244 02:34:35,045 --> 02:34:35,879 DISEASES. 3245 02:34:35,879 --> 02:34:38,048 AMP AIM WAS THEN LAUNCHED IN 3246 02:34:38,048 --> 02:34:44,020 2021 AND BUDGETED F$2021 AND BU 3247 02:34:44,020 --> 02:34:45,755 $62.36 MILLION. 3248 02:34:45,755 --> 02:34:49,059 AMP AIM IS MARCHED THROUGH THE 3249 02:34:49,059 --> 02:34:53,863 SAME FOUNDATION FOR NIH WITH 3250 02:34:53,863 --> 02:35:02,539 SUPPORT FROM AND THE NATIONAL 3251 02:35:02,539 --> 02:35:03,306 INFECTIOUS DISEASE AND EYE 3252 02:35:03,306 --> 02:35:05,875 INSTITUTE AND THE OFFICE OF 3253 02:35:05,875 --> 02:35:08,011 RESEARCH ON WOMEN'S HEALTH. 3254 02:35:08,011 --> 02:35:11,881 TODAY WITH 13 PUBLIC AND PRIVATE 3255 02:35:11,881 --> 02:35:13,984 PARTNERS. 3256 02:35:13,984 --> 02:35:23,560 THE DISEASES INCLUDE RHEUMATOID 3257 02:35:23,560 --> 02:35:25,462 ARTHRITIS AND SJOGREN'S DISEASE 3258 02:35:25,462 --> 02:35:27,797 AND OTHER DISEASES BECAUSE WE 3259 02:35:27,797 --> 02:35:29,499 KNOW THERE ARE ORAL 3260 02:35:29,499 --> 02:35:30,867 MANIFESTATIONS. 3261 02:35:30,867 --> 02:35:35,839 SO THE AMP AIM NETWORK 3262 02:35:35,839 --> 02:35:38,742 TECHNOLOGIES ARE VAST AND RANGE 3263 02:35:38,742 --> 02:35:41,978 FROM CLINICAL TO CELL LEVEL AND 3264 02:35:41,978 --> 02:35:46,249 MOLECULAR LEVEL OMICS DATA. 3265 02:35:46,249 --> 02:35:49,452 THE FALLS INTO THREE CATEGORIES. 3266 02:35:49,452 --> 02:35:52,122 OPPORTUNITY FUND PROGRAMS, PAIN 3267 02:35:52,122 --> 02:35:54,291 SUPPLEMENTS AND LEADERSHIP 3268 02:35:54,291 --> 02:35:55,725 SCHOLARS PROGRAM. 3269 02:35:55,725 --> 02:35:57,327 THE OPPORTUNITY FUNDS EVALUATE 3270 02:35:57,327 --> 02:36:01,298 NEW TECHNOLOGIES OR POTENTIAL 3271 02:36:01,298 --> 02:36:02,732 ANALYTIC APPROACHES AND PILOT 3272 02:36:02,732 --> 02:36:03,400 THESE APPROACHES FOR USE ACROSS 3273 02:36:03,400 --> 02:36:07,370 THE NETWORK. 3274 02:36:07,370 --> 02:36:08,672 AND IT PROVIDES AN 3275 02:36:08,672 --> 02:36:11,908 INFRASTRUCTURE TO FACILITATE THE 3276 02:36:11,908 --> 02:36:14,511 WORK OF THE NETWORK. 3277 02:36:14,511 --> 02:36:15,111 ACTUALLY ONE OF THE FIVE 3278 02:36:15,111 --> 02:36:17,213 OPPORTUNITY FUNDS WAS USED TO 3279 02:36:17,213 --> 02:36:19,149 LEVERAGE TRANS-DISEASE 3280 02:36:19,149 --> 02:36:21,084 PARTNERSHIPS TO LOOK AT WOMEN 3281 02:36:21,084 --> 02:36:22,819 WHO HAD SJOGREN'S DISEASE. 3282 02:36:22,819 --> 02:36:30,260 THE MOMS AND THEIR INFANTS. 3283 02:36:30,260 --> 02:36:32,729 THERE ARE NIH PAIN SUPPLEMENTS 3284 02:36:32,729 --> 02:36:34,230 THE SECOND AREA, HELPING TO 3285 02:36:34,230 --> 02:36:35,799 DELINEATE THE PAIN PHENOTYPES IN 3286 02:36:35,799 --> 02:36:40,704 PATIENTS THAT HAPPEN TO HAVE 3287 02:36:40,704 --> 02:36:43,606 RHEUMATOID ARTHRITIS OR LUPUS OR 3288 02:36:43,606 --> 02:36:44,741 SJOGREN'S AND ASSESS THE 3289 02:36:44,741 --> 02:36:46,776 DIFFERENCES BETWEEN THE 3290 02:36:46,776 --> 02:36:48,211 BIOMARKERS AND FUNCTIONAL BRAIN 3291 02:36:48,211 --> 02:36:51,514 MRIs AMONG THE PATIENTS WHO HAVE 3292 02:36:51,514 --> 02:36:53,083 THESE DISEASES AND HAVE PAIN AND 3293 02:36:53,083 --> 02:36:54,784 THOSE THAT MAY NOT. 3294 02:36:54,784 --> 02:36:56,386 AND AMONG THE TWO PAIN 3295 02:36:56,386 --> 02:36:57,987 SUPPLEMENTS, ONE ACTUALLY IS 3296 02:36:57,987 --> 02:36:59,689 LOOKING AT PAIN PHENOTYPES IN 3297 02:36:59,689 --> 02:37:02,792 SJOGREN'S DISEASE. 3298 02:37:02,792 --> 02:37:09,666 THE THIRD AND FINAL INITIATIVE 3299 02:37:09,666 --> 02:37:11,901 THAT GOES WITH TEAM SCIENCE 3300 02:37:11,901 --> 02:37:14,037 LEADERSHIP IS THE SCHOLARS 3301 02:37:14,037 --> 02:37:14,738 PROGRAM. 3302 02:37:14,738 --> 02:37:17,140 THIS LEADERSHIP SCHOLARS PROGRAM 3303 02:37:17,140 --> 02:37:20,744 IS ALSO A COLLABORATIVE OVER THE 3304 02:37:20,744 --> 02:37:24,047 BETWEEN AMP AIM, THE OFFICE OF 3305 02:37:24,047 --> 02:37:26,649 RESEARCH ON WOMEN'S HEALTH AND 3306 02:37:26,649 --> 02:37:27,917 THE NIH OFFICE ON DATA SCIENCE 3307 02:37:27,917 --> 02:37:31,888 STRATEGY OR ODSS WITH GOALS TO I 3308 02:37:31,888 --> 02:37:35,925 AM WHY -- IMPROVE WOMEN'S 3309 02:37:35,925 --> 02:37:37,560 HEALTH BY SUPPORTING SCHOLARS 3310 02:37:37,560 --> 02:37:41,831 DOING THIS WORK TO PROVIDE 3311 02:37:41,831 --> 02:37:44,567 STRUCTURED EXPOSURE TO TEAM 3312 02:37:44,567 --> 02:37:45,635 SCIENCE FOCUSSED ON AUTO UME 3313 02:37:45,635 --> 02:37:47,504 DISEASES AND ENHANCE THE 3314 02:37:47,504 --> 02:37:48,405 SCHOLAR'S LEADERSHIP AND 3315 02:37:48,405 --> 02:37:51,608 MENTORSHIP EXPERIENCES AND TO 3316 02:37:51,608 --> 02:37:54,377 ENCOURAGE AND DEVELOP NEW 3317 02:37:54,377 --> 02:37:55,111 LEADERS TO EXPLORE UNIQUE 3318 02:37:55,111 --> 02:37:57,147 SCIENTIFIC QUESTIONS AND 3319 02:37:57,147 --> 02:38:00,583 APPROACH AND CAN UTILIZE AND 3320 02:38:00,583 --> 02:38:02,719 REALLY LEVERAGE THE AMP AIM 3321 02:38:02,719 --> 02:38:03,353 INFRASTRUCTURE. 3322 02:38:03,353 --> 02:38:06,823 WE'LL HEAR FROM ONE OF THE SIX 3323 02:38:06,823 --> 02:38:07,490 CURRENT LEADERSHIP PROGRAM 3324 02:38:07,490 --> 02:38:11,895 AWARDEES TODAY. 3325 02:38:11,895 --> 02:38:15,265 AS WE LOOK AT THE GEOGRAPHIC 3326 02:38:15,265 --> 02:38:16,833 LOCATION OF THE AMP AIM SITES 3327 02:38:16,833 --> 02:38:19,502 AND PARTNERS YOU CAN SEE THEY'RE 3328 02:38:19,502 --> 02:38:23,840 ACROSS THE UNITED STATES AND IN 3329 02:38:23,840 --> 02:38:26,609 YELLOW CIRCLES THE STAMP SITES 3330 02:38:26,609 --> 02:38:30,146 WHERE WE HAVE GREAT GEOGRAPHIC 3331 02:38:30,146 --> 02:38:30,480 DISTRIBUTION. 3332 02:38:30,480 --> 02:38:33,349 IN FACT, BEYOND THE THREE SITES, 3333 02:38:33,349 --> 02:38:43,393 ONE BEING AT UCSF, THE SECOND 3334 02:38:43,393 --> 02:38:45,762 BEING IN OKLAHOMA, JOHNS HOPKINS 3335 02:38:45,762 --> 02:38:50,300 UNIVERSITY, THE FOURTH IS NIDCR 3336 02:38:50,300 --> 02:38:52,368 INTRAMURAL PROGRAMS AND A 3337 02:38:52,368 --> 02:38:54,237 CRITICAL ADDITIONAL PARTNER THE 3338 02:38:54,237 --> 02:38:54,971 SJOGREN'S FOUNDATION SERVING AS 3339 02:38:54,971 --> 02:38:55,905 AN ACTIVE PARTNER IN THIS 3340 02:38:55,905 --> 02:38:59,375 PROGRAM. 3341 02:38:59,375 --> 02:38:59,943 SO BRINGING IN OUR AFFECTED 3342 02:38:59,943 --> 02:39:05,482 COMMUNITY. 3343 02:39:05,482 --> 02:39:06,583 HEARING THEIR VOICE AND PUTTING 3344 02:39:06,583 --> 02:39:08,918 THE PATIENT AT THE CENTER. 3345 02:39:08,918 --> 02:39:11,187 SO THE SJOGREN'S TEAM FOR 3346 02:39:11,187 --> 02:39:13,089 ACCELERATING MEDICINES 3347 02:39:13,089 --> 02:39:14,891 PARTNERSHIP IS WHERE WE'LL GO 3348 02:39:14,891 --> 02:39:15,792 NEXT TODAY. 3349 02:39:15,792 --> 02:39:20,730 STARTING WITH AN OVERVIEW OF 3350 02:39:20,730 --> 02:39:23,900 STAMP, WHICH IS THE ACRONYM AND 3351 02:39:23,900 --> 02:39:26,769 ITS CLINICAL PIPELINE. 3352 02:39:26,769 --> 02:39:37,280 WE'LL HEAR FROM DR. SHIBOSSKI 3353 02:39:38,014 --> 02:39:42,185 AND HEAR FROM DR. BLAKE WARNER 3354 02:39:42,185 --> 02:39:46,189 FROM THE DIVISION OF INTRAMURAL 3355 02:39:46,189 --> 02:39:47,891 RESEARCH ON THE SINGLE CELL 3356 02:39:47,891 --> 02:39:51,060 SPATIAL TECHNOLOGIES ON SALIVARY 3357 02:39:51,060 --> 02:39:51,895 GLAND AND REPRESENTING THE 3358 02:39:51,895 --> 02:39:53,796 LEADERSHIP SCHOLARS PROGRAM IS 3359 02:39:53,796 --> 02:39:58,268 DR. SARA McCOY OF THE UNIVERSITY 3360 02:39:58,268 --> 02:40:00,570 OF WISCONSIN MADISON AND TALK 3361 02:40:00,570 --> 02:40:02,739 ABOUT LEVERAGING AMP AIM TO LOOK 3362 02:40:02,739 --> 02:40:13,249 AND LEARN ABOUT SALIVARY ME 3363 02:40:26,796 --> 02:40:35,438 MESOCHYMAL CELLS. 3364 02:40:35,438 --> 02:40:37,840 >> ABOUT AFTERNOON AND THANK YOU 3365 02:40:37,840 --> 02:40:47,116 SO MUCH FOR INVITING OUR TEAM TO 3366 02:40:47,116 --> 02:40:50,153 PROVIDE AN UPDATE ON THE 3367 02:40:50,153 --> 02:40:51,354 PARTNERSHIP WITH THE SJOGREN'S 3368 02:40:51,354 --> 02:40:54,223 TEAM AND KICK OFF THE SESSION BY 3369 02:40:54,223 --> 02:40:54,991 PRESENTING AN OVERVIEW AS WELL 3370 02:40:54,991 --> 02:40:59,829 AS THE CLINICAL PIPELINE SO 3371 02:40:59,829 --> 02:41:01,464 HERE'S OUR STEERING COMMITTEE 3372 02:41:01,464 --> 02:41:06,169 THAT CONSISTS OF FOUR SLEERDSHIP 3373 02:41:06,169 --> 02:41:16,713 TEAM MEMBERS, I AM AT UCSF AND 3374 02:41:22,285 --> 02:41:24,554 WE HAVE UNIVERSITY OF BERKELEY 3375 02:41:24,554 --> 02:41:26,122 AND SARA McCOY JOINED IN 3376 02:41:26,122 --> 02:41:30,493 SEPTEMBER OF LAST YEAR AND WE'RE 3377 02:41:30,493 --> 02:41:33,563 VERY HAPPY THAT HER LEADERSHIP 3378 02:41:33,563 --> 02:41:35,632 SCHOLARS PROGRAM FOCUSES ON 3379 02:41:35,632 --> 02:41:36,799 SJOGREN'S. 3380 02:41:36,799 --> 02:41:38,768 HIGHLIGHTING THE 3381 02:41:38,768 --> 02:41:42,605 MULTI-DISCIPLINARY ASPECT OF 3382 02:41:42,605 --> 02:41:45,808 STAMP AND WITH RHEUMATOLOGY, 3383 02:41:45,808 --> 02:41:50,446 REPRESENTED IN EACH OF OUR FIVE 3384 02:41:50,446 --> 02:41:55,885 CLINICAL SITES AND IN ADDITION 3385 02:41:55,885 --> 02:41:59,889 TO EXPERTISE WE HAVE GENOMICS 3386 02:41:59,889 --> 02:42:01,557 AND COMPUTATIONAL BIOLOGY 3387 02:42:01,557 --> 02:42:02,792 REFLECTED IN THE PRESENTATION 3388 02:42:02,792 --> 02:42:04,394 AFTER MINE. 3389 02:42:04,394 --> 02:42:07,196 JENNIFER MENTIONED THE PATIENT'S 3390 02:42:07,196 --> 02:42:09,666 VOICE WHO WERE DELIGHTED TO HAVE 3391 02:42:09,666 --> 02:42:13,136 AS PART OF THE GROUP AND THEN AN 3392 02:42:13,136 --> 02:42:15,371 INTERESTING FACT IS AMONG 35 3393 02:42:15,371 --> 02:42:16,039 INVESTIGATORS AND COLLABORATORS 3394 02:42:16,039 --> 02:42:20,710 WITHIN STAMP, 63% ARE WOMEN 3395 02:42:20,710 --> 02:42:23,680 WORTH NOTING. 3396 02:42:23,680 --> 02:42:25,014 AFTER COMPLETING BOTH PLANNING 3397 02:42:25,014 --> 02:42:27,483 AND PILOT PHASES WE'RE IN THE 3398 02:42:27,483 --> 02:42:30,586 MIX OF A SCALE UP PHASE THAT AT 3399 02:42:30,586 --> 02:42:33,990 UNDERSTANDING THE PHENOTYPIC AND 3400 02:42:33,990 --> 02:42:38,161 MOLECU 3401 02:42:38,161 --> 02:42:38,795 MOLECU 3402 02:42:38,795 --> 02:42:41,164 MOLECU 3403 02:42:41,164 --> 02:42:44,967 MOLECULAR HETEROGENEITY IN THE 3404 02:42:44,967 --> 02:42:47,904 DISEASE AND ALL TO IDENTIFY 3405 02:42:47,904 --> 02:42:51,708 THERAPEUTIC TARGETS TO IMPROVE 3406 02:42:51,708 --> 02:42:52,809 ADVANCED DISEASE. 3407 02:42:52,809 --> 02:43:00,717 SO THE FIVE-YEAR SCIENTIFIC 3408 02:43:00,717 --> 02:43:06,189 AGENDA DEVELOPED IS FOCUSSED ON 3409 02:43:06,189 --> 02:43:07,190 THREE THEMES. 3410 02:43:07,190 --> 02:43:08,391 FIRST PREDICTION OF SJOGREN'S 3411 02:43:08,391 --> 02:43:09,225 DISEASE DEVELOPMENT AND 3412 02:43:09,225 --> 02:43:11,394 PROGRESSION. 3413 02:43:11,394 --> 02:43:15,898 WE HAVE THE OPPORTUNITY TO 3414 02:43:15,898 --> 02:43:17,567 RECALL PARTICIPANTS IN THE PRIOR 3415 02:43:17,567 --> 02:43:20,169 F COHORTS AND SOME OF THESE WERE 3416 02:43:20,169 --> 02:43:21,504 ENROLLED 20 YEARS AGO. 3417 02:43:21,504 --> 02:43:24,140 THAT'S A REALLY GOOD WAY TO 3418 02:43:24,140 --> 02:43:27,643 EXPLORE MOLECULAR CHANGES OVER 3419 02:43:27,643 --> 02:43:33,549 TIME WITHIN SALIVARY GLANDS AND 3420 02:43:33,549 --> 02:43:34,751 LOOK AT PHENOTYPIC FEATURES 3421 02:43:34,751 --> 02:43:36,719 ASSOCIATED WITH PROGRESSION. 3422 02:43:36,719 --> 02:43:42,358 THE SECOND THEME PERTAINS TO THE 3423 02:43:42,358 --> 02:43:48,264 ELUCIDATION OF SJOGREN'S DISEASE 3424 02:43:48,264 --> 02:43:51,267 HETEROGENEITY AND LOOK AT 3425 02:43:51,267 --> 02:43:51,934 COVARIANTS OF SJOGREN'S DISEASE 3426 02:43:51,934 --> 02:43:56,806 AND DISEASE ACTIVITY AND DAMAGE. 3427 02:43:56,806 --> 02:44:01,010 FINALLY, THE THIRD AIM FOCUSES 3428 02:44:01,010 --> 02:44:07,917 ON THE GRANULAR TROPISM AND 3429 02:44:07,917 --> 02:44:13,055 POSITIVE SJOGREN'S DISEASE AND 3430 02:44:13,055 --> 02:44:18,895 PARTICIPANTS AND ANTIGENS AND 3431 02:44:18,895 --> 02:44:22,231 HORMONES ARE AMONG THE POTENTIAL 3432 02:44:22,231 --> 02:44:25,668 DETERMINATES OF TROPISM WE'LL BE 3433 02:44:25,668 --> 02:44:26,335 EXPLORING. 3434 02:44:26,335 --> 02:44:27,637 WITH RESPECT TO INCLUSION 3435 02:44:27,637 --> 02:44:29,672 DESIGN, STAMP IS A 3436 02:44:29,672 --> 02:44:31,874 CROSS-SECTIONAL STUDY WITH A 3437 02:44:31,874 --> 02:44:33,943 SINGLE STUDY VISIT BUT DOES HAVE 3438 02:44:33,943 --> 02:44:39,182 A LONGITUDINAL COMPONENT BECAUSE 3439 02:44:39,182 --> 02:44:46,756 OF THE RECALL AND SOME WERE 3440 02:44:46,756 --> 02:44:50,793 RECRUITED IN THE SICC PROJECT 3441 02:44:50,793 --> 02:44:54,497 AND WE'LL RECALL 185 IN THE 3442 02:44:54,497 --> 02:44:57,433 STAMP FOLLOW-UP COHORT. 3443 02:44:57,433 --> 02:45:01,470 IN THE STAMP MAIN COHORT WE ARE 3444 02:45:01,470 --> 02:45:06,642 ENROLLING 300 PARTICIPANTS WITH 3445 02:45:06,642 --> 02:45:07,910 SIGNS AND SYMPTOMS OF SJOGREN'S 3446 02:45:07,910 --> 02:45:12,515 DISEASE WITH THE SAME INCLUSION 3447 02:45:12,515 --> 02:45:14,617 CRITERIA AND ESTIMATE 40% OF 3448 02:45:14,617 --> 02:45:18,387 THESE WILL MEET THE 2016 ACR 3449 02:45:18,387 --> 02:45:19,889 CRITERIA ONCE WORKED UP. 3450 02:45:19,889 --> 02:45:24,694 WE HAVE A SMALL GROUP OF 3451 02:45:24,694 --> 02:45:29,699 SJOGREN'S DISEASE SLE OVERLAP 3452 02:45:29,699 --> 02:45:34,203 COHORT THAT JENNIFER ALLUDED TO 3453 02:45:34,203 --> 02:45:38,808 AND 63 HEALTHY CONTROLS 3454 02:45:38,808 --> 02:45:41,477 RECRUITED AT NIDCR SO THE 3455 02:45:41,477 --> 02:45:42,845 SPECIAL HEALTHY CONTROL 3456 02:45:42,845 --> 02:45:43,479 RECRUITMENT PROJECT AND THROUGH 3457 02:45:43,479 --> 02:45:53,089 THE SITES. 3458 02:45:53,089 --> 02:45:55,258 AND WE HAVE DOMAINS EVALUATED 3459 02:45:55,258 --> 02:46:00,863 WHEN WE WORK SOMEBODY UP FOR 3460 02:46:00,863 --> 02:46:07,737 SJOGREN'S THE ORAL, SALIVARY AND 3461 02:46:07,737 --> 02:46:10,139 OCULAR AND WE INCLUDED SALIVARY 3462 02:46:10,139 --> 02:46:15,077 GLAND ULTRASOUND IMPORTANT TO 3463 02:46:15,077 --> 02:46:17,813 EXPLORE SALIVARY GLANDS IN THE 3464 02:46:17,813 --> 02:46:19,882 SQUEEZE AND INCLUDED DISEASE 3465 02:46:19,882 --> 02:46:24,954 ACTIVITY AND THE PATIENT 3466 02:46:24,954 --> 02:46:27,123 REPORTED AND CLINICALLY ASSESSED 3467 02:46:27,123 --> 02:46:28,190 S DYE. 3468 02:46:28,190 --> 02:46:31,861 JENNIFER REFERRED TO THE PAIN 3469 02:46:31,861 --> 02:46:32,161 SUPPLEMENTS. 3470 02:46:32,161 --> 02:46:34,597 WE HAVE EXTENSIVE PAIN 3471 02:46:34,597 --> 02:46:35,231 QUESTIONNAIRES THROUGH THE 3472 02:46:35,231 --> 02:46:37,500 SUPPLEMENT AND ACROSS ALL 3473 02:46:37,500 --> 02:46:40,770 DISEASES AND EXTENDED THE 3474 02:46:40,770 --> 02:46:42,972 NEUROLOGIC EXAM COMPARED TO WHAT 3475 02:46:42,972 --> 02:46:47,877 WE USED TO DO WITH SICCA AND 3476 02:46:47,877 --> 02:46:48,110 RMF. 3477 02:46:48,110 --> 02:46:55,885 IN RED ARE ALL THE SPECIMENS 3478 02:46:55,885 --> 02:46:57,420 COLLECTED, PROCESSED LOCALLY AND 3479 02:46:57,420 --> 02:47:00,256 SUBMITTED TO THE TISSUE 3480 02:47:00,256 --> 02:47:08,798 REPOSITORY CENTER OMRN. 3481 02:47:08,798 --> 02:47:10,132 ANOTHER TRANS DISEASE WHERE 3482 02:47:10,132 --> 02:47:12,535 MICROBIOME IS STUDIED IN STOOL 3483 02:47:12,535 --> 02:47:13,202 SPECIMENS BEING DONE ACROSS ALL 3484 02:47:13,202 --> 02:47:15,738 FOUR DISEASES. 3485 02:47:15,738 --> 02:47:19,408 SO WE'VE COMPLETED FOUR PILOTS. 3486 02:47:19,408 --> 02:47:25,848 WITH PILOT 1A AIMED AT ASSESSING 3487 02:47:25,848 --> 02:47:31,854 THE CLINICAL OPERATION, SAMPLE 3488 02:47:31,854 --> 02:47:34,590 PROCUREMENT AND FINALIZED AND 3489 02:47:34,590 --> 02:47:37,093 TESTED SOPs, CLINICAL RESEARCH 3490 02:47:37,093 --> 02:47:39,395 FORMS AND MANUALS ACROSS THE 3491 02:47:39,395 --> 02:47:39,695 FIVE SITES. 3492 02:47:39,695 --> 02:47:43,599 WE'VE DONE COLLABORATION OF THE 3493 02:47:43,599 --> 02:47:47,236 SALIVARY GRAND ULTRASOUND AND 3494 02:47:47,236 --> 02:47:49,739 HOW THE SCORE IS USED FOR THE 3495 02:47:49,739 --> 02:47:51,874 ULTRASOUNDS. 3496 02:47:51,874 --> 02:47:57,113 OUR PATHOLOGISTS WHO ARE LEADING 3497 02:47:57,113 --> 02:48:00,883 EVERY SINGLE HME ON THE PLATFORM 3498 02:48:00,883 --> 02:48:01,083 HALO. 3499 02:48:01,083 --> 02:48:02,785 SO MAKE AND RICHARD HAVE BEEN 3500 02:48:02,785 --> 02:48:08,457 CALIBRATED AND USING SICCA DATA 3501 02:48:08,457 --> 02:48:11,427 AND WE'VE ALSO DEVELOPED A DATA 3502 02:48:11,427 --> 02:48:15,898 SAFETY MONITORING PLAN THAT'S 3503 02:48:15,898 --> 02:48:18,100 BEEN APPROVED BY NIAMS AND NIDCR 3504 02:48:18,100 --> 02:48:19,869 AND SAFETY OFFICERS REVIEWED AND 3505 02:48:19,869 --> 02:48:20,469 APPROVED TWO OF OUR QUARTERLY 3506 02:48:20,469 --> 02:48:24,974 REPORTS. 3507 02:48:24,974 --> 02:48:27,877 THERE ARE THREE TISSUE-FOCUSSED 3508 02:48:27,877 --> 02:48:29,945 PILOTS THAT HAVE COMPARED 3509 02:48:29,945 --> 02:48:34,750 PROTOCOLS FOR CRYO PRESERVATION 3510 02:48:34,750 --> 02:48:37,086 AND DE-ASSOCIATION AND 3511 02:48:37,086 --> 02:48:38,687 PROCESSING AS WELL AS FIXATION 3512 02:48:38,687 --> 02:48:39,955 OF THE GLANDS AND SELECTION OF 3513 02:48:39,955 --> 02:48:49,265 SPATIAL PLATFORMS. 3514 02:48:49,265 --> 02:48:51,200 PART OF THIS IS FEASIBILITY OF 3515 02:48:51,200 --> 02:48:55,404 NEW TECHNOLOGY TO ASSESS THE 3516 02:48:55,404 --> 02:48:57,339 RESTORABLE PRESERVED GLANDULAR 3517 02:48:57,339 --> 02:49:05,347 TISSUE FROM SICCA AND OMRF AND 3518 02:49:05,347 --> 02:49:07,883 HEAR WHAT WAS CONDUCTED IN THE 3519 02:49:07,883 --> 02:49:09,685 LABS. 3520 02:49:09,685 --> 02:49:15,891 TO DATE WE HAVE ENROLLED 184 3521 02:49:15,891 --> 02:49:18,627 PARTICIPANTS ACROSS ALL OF OUR 3522 02:49:18,627 --> 02:49:20,463 CLINICAL SITES. 3523 02:49:20,463 --> 02:49:24,934 YOU CAN SEE THE LARGEST NUMBER 3524 02:49:24,934 --> 02:49:27,169 IS IN THE MAIN COHORT. 3525 02:49:27,169 --> 02:49:31,307 WE HAVE ALMOST 20 HEALTHY 3526 02:49:31,307 --> 02:49:33,075 CONTROLS AND FOLLOW-UP AND AMONG 3527 02:49:33,075 --> 02:49:35,811 THE PARTICIPANTS IN WHOM WE'VE 3528 02:49:35,811 --> 02:49:37,012 BEEN ABLE TO ESTABLISH THE 3529 02:49:37,012 --> 02:49:38,481 CLASSIFICATION CRITERIA AND HAVE 3530 02:49:38,481 --> 02:49:40,349 RESULTS AVAILABLE THIS IS A 3531 02:49:40,349 --> 02:49:43,018 DISTRIBUTION WHETHER OR NOT THEY 3532 02:49:43,018 --> 02:49:43,819 MEET CRITERIA OR WHETHER THEY'RE 3533 02:49:43,819 --> 02:49:47,423 A HEALTHY CONTROL. 3534 02:49:47,423 --> 02:49:50,126 IT'S INTERESTING TO LOOK AT HOW 3535 02:49:50,126 --> 02:49:53,996 WE'RE DOING COMPARED TO 3536 02:49:53,996 --> 02:49:54,330 EXPECTATIONS. 3537 02:49:54,330 --> 02:49:55,464 SO THE BLUE BARS REPRESENT A 3538 02:49:55,464 --> 02:49:57,967 PLANNED ENROLLMENT AND THE 3539 02:49:57,967 --> 02:50:01,837 MAGENTA BAR REPRESENTS ACTUAL 3540 02:50:01,837 --> 02:50:02,371 ENROLLMENT. 3541 02:50:02,371 --> 02:50:03,205 WE'RE A LITTLE BIT BEHIND 3542 02:50:03,205 --> 02:50:06,909 BECAUSE WE STARTED SIX MONTHS 3543 02:50:06,909 --> 02:50:10,746 AFTER THE EXPECTED STARTED DATE. 3544 02:50:10,746 --> 02:50:13,082 YOU CAN IMAGINE WE HAVE 3545 02:50:13,082 --> 02:50:17,486 EXTENSIVE SOPs NOT ONLY IN THE 3546 02:50:17,486 --> 02:50:19,688 SJOGREN'S BUT ACROSS OTHER 3547 02:50:19,688 --> 02:50:21,824 DISEASES AND THEY HAD TO BE 3548 02:50:21,824 --> 02:50:23,692 REVIEWED AND APPROVED CENTRALLY. 3549 02:50:23,692 --> 02:50:24,827 THAT TOOK A LITTLE BIT LONGER 3550 02:50:24,827 --> 02:50:25,628 THAN EXPECTED. 3551 02:50:25,628 --> 02:50:28,497 ALSO WHEN WE WERE PILOTING THE 3552 02:50:28,497 --> 02:50:29,732 CLINICAL ASSESSMENTS WE COULD 3553 02:50:29,732 --> 02:50:31,700 ONLY SEE ONE PARTICIPANT PER 3554 02:50:31,700 --> 02:50:34,170 SESSION WHEREAS NOW WE SEE EVERY 3555 02:50:34,170 --> 02:50:36,338 SINGLE CLINICAL SITE IS 3556 02:50:36,338 --> 02:50:38,107 TYPICALLY ENROLLING THREE 3557 02:50:38,107 --> 02:50:38,741 PARTICIPANTS PER SESSION. 3558 02:50:38,741 --> 02:50:39,675 AND WHAT'S INTERESTING IS WHEN 3559 02:50:39,675 --> 02:50:43,379 WE LOOK AT THE ENROLLMENT IN THE 3560 02:50:43,379 --> 02:50:46,615 DIFFERENT SUBCOHORTS YOU CAN SEE 3561 02:50:46,615 --> 02:50:49,385 WITH THE SOLID BAR IS THE ACTUAL 3562 02:50:49,385 --> 02:50:52,288 ENROLLMENT AND PATTERN BAR 3563 02:50:52,288 --> 02:50:54,156 REPRESENTING THE EXPECTED 3564 02:50:54,156 --> 02:50:59,995 ENROLLMENT, YOU CAN SEE AT UCSF, 3565 02:50:59,995 --> 02:51:06,468 U.C. BERKELEY AND JOHNS HOPKINS 3566 02:51:06,468 --> 02:51:08,370 AND WE'RE AHEAD OF ACTUAL 3567 02:51:08,370 --> 02:51:09,238 ENROLLMENT VERSUS PLANNED. 3568 02:51:09,238 --> 02:51:12,608 IT'S IN THE FOLLOW-UP COHORT 3569 02:51:12,608 --> 02:51:13,175 WE'RE BEHIND. 3570 02:51:13,175 --> 02:51:14,843 THIS IS A UNIQUE GROUP AND DID 3571 02:51:14,843 --> 02:51:17,913 NOT WANT TO START ENROLLMENT OF 3572 02:51:17,913 --> 02:51:20,883 THE GROUP TOO EARLY AS WE'RE 3573 02:51:20,883 --> 02:51:25,621 PILOTING THE CLINICAL PROTOCOL 3574 02:51:25,621 --> 02:51:26,855 SOMETIMES TISSUE GETS EXHAUSTED. 3575 02:51:26,855 --> 02:51:31,660 WE'RE KEEPING THIS FOR NOW AND 3576 02:51:31,660 --> 02:51:34,563 GEARED UP AND ARE ACTIVELY 3577 02:51:34,563 --> 02:51:35,264 FOLLOWING UP PARTICIPANTS AT 3578 02:51:35,264 --> 02:51:36,332 THIS POINT. 3579 02:51:36,332 --> 02:51:39,969 A FEW WORDS ABOUT THE NETWORK 3580 02:51:39,969 --> 02:51:41,804 EARLY DISEASE PROJECT THAT 3581 02:51:41,804 --> 02:51:43,372 SJOGREN'S IS PART OF THAT 3582 02:51:43,372 --> 02:51:45,274 INVESTIGATE THE SHARED MOLECULAR 3583 02:51:45,274 --> 02:51:47,376 PATHWAYS AND INTERACTIONS ACROSS 3584 02:51:47,376 --> 02:51:50,212 ALL FOUR DISEASES. 3585 02:51:50,212 --> 02:51:54,350 SO DISEASE-SPECIFIC TISSUES WILL 3586 02:51:54,350 --> 02:51:55,985 BE DEEPLY PHENOTYPE USING SINGLE 3587 02:51:55,985 --> 02:51:57,853 CELL ANALYSES, ETCETERA. 3588 02:51:57,853 --> 02:52:00,623 EACH OF THE DISEASE TEAM WILL 3589 02:52:00,623 --> 02:52:02,358 PROVIDE DISEASE-SPECIFIC TISSUE 3590 02:52:02,358 --> 02:52:03,892 IN AT LEAST 12 PARTICIPANTS. 3591 02:52:03,892 --> 02:52:09,465 WE'VE HAD TO COME UP WITH A 3592 02:52:09,465 --> 02:52:10,532 DEFINITION FOR EARLY SJOGREN'S 3593 02:52:10,532 --> 02:52:12,901 DISEASE AS YOU KNOW THERE IS NO 3594 02:52:12,901 --> 02:52:14,503 ESTABLISH DEFINITION FOR EARLY 3595 02:52:14,503 --> 02:52:14,870 DISEASE. 3596 02:52:14,870 --> 02:52:16,839 WE PROPOSED TO DERIVE A 3597 02:52:16,839 --> 02:52:18,440 DEFINITION FROM INCLUSION 3598 02:52:18,440 --> 02:52:20,843 CRITERIA OFTEN USED BY INDUSTRY 3599 02:52:20,843 --> 02:52:22,978 PARTNERS FOR RECRUITMENT INTO 3600 02:52:22,978 --> 02:52:23,279 TRIALS. 3601 02:52:23,279 --> 02:52:27,650 THIS IS BASICALLY THE CRITERIA 3602 02:52:27,650 --> 02:52:28,217 WE ARE USING FOR THIS EARLY 3603 02:52:28,217 --> 02:52:35,324 DISEASE PROJECT. 3604 02:52:35,324 --> 02:52:38,894 NOW, REMEMBERING SJOGREN'S IS A 3605 02:52:38,894 --> 02:52:41,130 HETEROGENOUS DISEASE IT'S NOT 3606 02:52:41,130 --> 02:52:43,766 ONLY IMPORTANT TO HAVE POSITIVE 3607 02:52:43,766 --> 02:52:46,435 SJOGREN'S PARTICIPANTS AND 3608 02:52:46,435 --> 02:52:49,605 MAKING YOU ARE SURE THEY HAVE 3609 02:52:49,605 --> 02:52:51,540 SALIVARY GLANDS IF THEY HAVE A 3610 02:52:51,540 --> 02:52:53,509 FOCUS OR ONE OR MORE THEY'RE 3611 02:52:53,509 --> 02:52:55,444 MORE LIKELY TO FROM FIBROTIC 3612 02:52:55,444 --> 02:52:59,081 CHANGES IN THEIR GLANDS. 3613 02:52:59,081 --> 02:53:00,582 THE OTHER GROUP IS THE RO 3614 02:53:00,582 --> 02:53:02,885 NEGATIVE BECAUSE IT MAY REFLECT 3615 02:53:02,885 --> 02:53:04,086 LESS SEVERE AND POSSIBLY EARLIER 3616 02:53:04,086 --> 02:53:07,923 DISEASE AND AMONG THE CONTROLS, 3617 02:53:07,923 --> 02:53:09,458 WE WILL BE RECRUITING 3618 02:53:09,458 --> 02:53:11,560 SYMPTOMATIC AND HEALTHY 3619 02:53:11,560 --> 02:53:11,927 CONTROLS. 3620 02:53:11,927 --> 02:53:14,863 THE MAJORITY WILL BE IN OUR RO 3621 02:53:14,863 --> 02:53:21,170 POSITIVE SJOGREN'S PARTICIPANTS. 3622 02:53:21,170 --> 02:53:22,805 WE HAVE AVAILABLE PARTICIPANTS 3623 02:53:22,805 --> 02:53:24,573 FOR EVERY ONE OF THESE 3624 02:53:24,573 --> 02:53:31,013 CATEGORIES AND THE POSITIVE SUB 3625 02:53:31,013 --> 02:53:32,614 GROUP HAS TWO TIME POINTS AS 3626 02:53:32,614 --> 02:53:38,854 PART OF SICCA AND ONE WITH ONE 3627 02:53:38,854 --> 02:53:43,759 EXISTING VISIT ALL HAVE 3628 02:53:43,759 --> 02:53:47,196 AVAILABLE PLASMA AND SARIN AND 3629 02:53:47,196 --> 02:53:50,866 WILL BE AN OPPORTUNITY TO DO AN 3630 02:53:50,866 --> 02:53:54,536 ASSESSMENT AMONG THE PROJECT. 3631 02:53:54,536 --> 02:53:57,573 AND GIVING A SNAPSHOT OF THE 3632 02:53:57,573 --> 02:53:58,741 OPPORTUNITY FUND JENNIFER 3633 02:53:58,741 --> 02:54:00,075 REFERRED TO THE COLLABORATION 3634 02:54:00,075 --> 02:54:03,812 BETWEEN STAMP, THE SLE GROUP AT 3635 02:54:03,812 --> 02:54:06,014 NCU, SYMPTOMS BIOLOGY CORE AND 3636 02:54:06,014 --> 02:54:08,884 THE TRC AND IT'S TO EVALUATE 3637 02:54:08,884 --> 02:54:11,920 MOTHERS OF CHILDREN WITH 3638 02:54:11,920 --> 02:54:13,522 NEONATAL LUPUS TO PROVIDE 3639 02:54:13,522 --> 02:54:15,858 INSIGHT INTO THE PROTECTIVE AND 3640 02:54:15,858 --> 02:54:17,159 PERMISSIVE FACTORS OF SJOGREN'S 3641 02:54:17,159 --> 02:54:17,726 DISEASE. 3642 02:54:17,726 --> 02:54:20,863 THE MAIN QUESTION BEING WHAT ARE 3643 02:54:20,863 --> 02:54:25,100 THE CHARACTERISTIC OF SALIVARY 3644 02:54:25,100 --> 02:54:32,875 GLAND TISSUES IN ASYMPTOMATIC 3645 02:54:32,875 --> 02:54:34,209 INDIVIDUALS AND HAVE THE 3646 02:54:34,209 --> 02:54:43,185 REGISTRY OF THE NEONATAL LUPUS 3647 02:54:43,185 --> 02:54:47,423 AND HAVE AN IRB AND ARE ABOUT TO 3648 02:54:47,423 --> 02:54:50,859 FINISH THE COLLABORATION FOR THE 3649 02:54:50,859 --> 02:54:51,927 SALIVARY GLAND ULTRASOUND AND 3650 02:54:51,927 --> 02:54:54,563 START IN OCTOBER. 3651 02:54:54,563 --> 02:54:55,798 I'LL STOP SHARING MY SLIDE SO 3652 02:54:55,798 --> 02:54:56,899 BLAKE WARNER CAN COME ON. 3653 02:54:56,899 --> 02:54:59,301 THE ACKNOWLEDGEMENT SLIDE WILL 3654 02:54:59,301 --> 02:55:01,270 COME AT THE END WITH CHRIS' 3655 02:55:01,270 --> 02:55:02,871 TALK. 3656 02:55:02,871 --> 02:55:12,981 THANK YOU VERY MUCH. 3657 02:55:12,981 --> 02:55:15,350 >> THIS, CAROLINE FOR THE 3658 02:55:15,350 --> 02:55:16,652 INTRODUCTION AND THANK YOU FOR 3659 02:55:16,652 --> 02:55:19,221 COUNCIL FOR THE OPPORTUNITY TO 3660 02:55:19,221 --> 02:55:20,856 TALK TODAY. 3661 02:55:20,856 --> 02:55:25,527 I'M BLAKE WARNER A STADTMAN 3662 02:55:25,527 --> 02:55:27,162 TRACK INVESTIGATOR. 3663 02:55:27,162 --> 02:55:35,904 I'LL TALK ABOUT SPATIAL 3664 02:55:35,904 --> 02:55:38,874 RECONSTRUCTION OF SJOGREN'S 3665 02:55:38,874 --> 02:55:49,017 DISEASE. 3666 02:55:50,419 --> 02:56:00,596 IT IS SHARING? 3667 02:56:30,459 --> 02:56:32,728 TO SELECT THE MOST SPATIAL 3668 02:56:32,728 --> 02:56:34,429 PERFORMING PLATFORM WE CONDUCTED 3669 02:56:34,429 --> 02:56:38,534 PILOTS WITH THE READILY 3670 02:56:38,534 --> 02:56:48,210 AVAILABLE INSTRUMENTS THE XENIUM 3671 02:56:48,210 --> 02:56:55,350 GENOMICS AND COSMX PLATFORM. 3672 02:56:55,350 --> 02:56:56,218 THOUGH BOTH INSTRUMENTS 3673 02:56:56,218 --> 02:56:57,986 PERFORMED EQUALLY WELL AT THE 3674 02:56:57,986 --> 02:57:01,924 PER CELL LEVEL WITH SOME BETTER 3675 02:57:01,924 --> 02:57:10,966 CONSISTENCY WINNING OUT TO THE 3676 02:57:10,966 --> 02:57:15,704 XENIUM PLATFORM IT ALLOWS MORE 3677 02:57:15,704 --> 02:57:22,644 CELLS TO BE CAPTURED AND THE 3678 02:57:22,644 --> 02:57:26,081 COSMX WAS DIFFERENT IT WAS 3679 02:57:26,081 --> 02:57:27,916 IMPORTANT TO SELECT OTHER SINGLE 3680 02:57:27,916 --> 02:57:32,187 CELL PLATFORMS THAT MARRIED WELL 3681 02:57:32,187 --> 02:57:33,722 WITH THE XENIUM SPATIAL 3682 02:57:33,722 --> 02:57:35,157 PLATFORM. 3683 02:57:35,157 --> 02:57:37,225 THE TECHNOLOGY WE PLANNED TO USE 3684 02:57:37,225 --> 02:57:39,928 ACROSS STAMP USES FORMAL AND 3685 02:57:39,928 --> 02:57:44,900 FIXED EMBEDDED TISSUES AND A 3686 02:57:44,900 --> 02:57:46,468 SIMILAR STRATEGY TO USING PROBES 3687 02:57:46,468 --> 02:57:48,470 TO QUANTIFY GENE EXPRESSION IN 3688 02:57:48,470 --> 02:57:49,438 INDIVIDUAL CELLS. 3689 02:57:49,438 --> 02:57:53,809 THIS WILL BE FURTHER DETAILED BY 3690 02:57:53,809 --> 02:57:59,448 DR. CHRISTOPHER LESSARD AFTER MY 3691 02:57:59,448 --> 02:57:59,781 PRESENTATION. 3692 02:57:59,781 --> 02:58:02,851 AND IT USES TARGETS AND 3693 02:58:02,851 --> 02:58:04,620 AMPLIFICATION TO AMPLIFY THE 3694 02:58:04,620 --> 02:58:08,290 PRESENCE OF THAT TRANSCRIPT AND 3695 02:58:08,290 --> 02:58:10,158 FLUORESCENCE DETECTION AS 3696 02:58:10,158 --> 02:58:11,760 QUANTIFIED BY THE XENIUM 3697 02:58:11,760 --> 02:58:15,897 ANALYZER TO LOCALIZE INDIVIDUAL 3698 02:58:15,897 --> 02:58:19,067 TRANSCRIPTS AND CELLS ACROSS THE 3699 02:58:19,067 --> 02:58:20,936 TISSUES AND FOBs SELECTED ON 3700 02:58:20,936 --> 02:58:27,909 YOUR SLIDE. 3701 02:58:27,909 --> 02:58:31,213 HOWEVER THE FACT WE WERE ABLE TO 3702 02:58:31,213 --> 02:58:35,350 COLLECT THE DATA IS IS ONE 3703 02:58:35,350 --> 02:58:35,550 THING. 3704 02:58:35,550 --> 02:58:37,719 THE NEXT PART WAS COULD WE USING 3705 02:58:37,719 --> 02:58:39,655 THE AVAILABLE INFORMATION ABOUT 3706 02:58:39,655 --> 02:58:41,990 THE COMPOSITION OF THE GLANDS TO 3707 02:58:41,990 --> 02:58:44,760 ADEQUATELY PREDICT WHAT CELL 3708 02:58:44,760 --> 02:58:45,861 TYPES WERE PRESENT IN THE 3709 02:58:45,861 --> 02:58:47,062 SPATIAL CONTEXT. 3710 02:58:47,062 --> 02:58:49,431 SO WE USED OUR EXISTING 3711 02:58:49,431 --> 02:58:53,168 UNPUBLISHED AND PUBLISHED 3712 02:58:53,168 --> 02:58:54,670 THREE-PRIME SINGLE CELL 3713 02:58:54,670 --> 02:58:56,705 SEQUENCING DATA FROM THE MINOR 3714 02:58:56,705 --> 02:58:58,473 SALARY GLANDS AND TRANSFERRED 3715 02:58:58,473 --> 02:59:00,509 ANCHORS BETWEEN THE SINGLE CELL 3716 02:59:00,509 --> 02:59:02,110 AND THE SPATIAL TRANSCRIPTOMICS 3717 02:59:02,110 --> 02:59:05,847 WHICH MEANS WE TOOK THE CELL 3718 02:59:05,847 --> 02:59:07,616 I.D.s WE FOUND IN SINGLE CELL 3719 02:59:07,616 --> 02:59:10,986 SPACE AND APPLIED IT TO THE 3720 02:59:10,986 --> 02:59:12,354 SPATIAL FACE ACROSS THREE 3721 02:59:12,354 --> 02:59:17,592 DIFFERENT CUSTOM PANELS USING A 3722 02:59:17,592 --> 02:59:20,929 280 PLEX BREAST CANCER PANEL AND 3723 02:59:20,929 --> 02:59:22,798 PANEL CONDUCTED IN COLLABORATION 3724 02:59:22,798 --> 02:59:25,567 WITH AMP AIM AND THROUGH A 3725 02:59:25,567 --> 02:59:27,202 COLLABORATION BETWEEN AMP AIM 3726 02:59:27,202 --> 02:59:28,904 AND 10X GENOMICS WE WERE ONE OF 3727 02:59:28,904 --> 02:59:37,612 THE FIRST USERS TO USE THE 5K OR 3728 02:59:37,612 --> 02:59:38,146 PRIME GENOMICS PANEL. 3729 02:59:38,146 --> 02:59:44,920 WE ALSO UNDERSTOOD WE NEEDED TO 3730 02:59:44,920 --> 02:59:47,255 OPTIMIZE NOT ONLY WHICH PLATFORM 3731 02:59:47,255 --> 02:59:51,793 TO USE BUT THE BEST FORMAT FOR 3732 02:59:51,793 --> 02:59:52,761 ANALYZING THE GLANDS IN THE 3733 02:59:52,761 --> 02:59:53,862 STAMP PROGRAM. 3734 02:59:53,862 --> 02:59:57,099 SO ONE OF THE WAYS TO MAXIMIZE 3735 02:59:57,099 --> 03:00:00,001 THESE FRAMES AND DECREASE COST 3736 03:00:00,001 --> 03:00:02,437 AND DECREASE VARIABILITY ACROSS 3737 03:00:02,437 --> 03:00:07,809 THE MULTIPLE RUNGS WE PLANNED TO 3738 03:00:07,809 --> 03:00:08,677 CONSTRUCT MINOR SALIVARY GLAND 3739 03:00:08,677 --> 03:00:09,644 TISSUE MICRO ARRAY. 3740 03:00:09,644 --> 03:00:11,913 THIS IS WHAT WE CONSTRUCTED WITH 3741 03:00:11,913 --> 03:00:14,750 THE NCI THAT REPRESENTS 44 CORES 3742 03:00:14,750 --> 03:00:20,889 FROM 22 PATIENTS ON ONE SLIDE. 3743 03:00:20,889 --> 03:00:25,260 YOU CAN SEE EVEN AT THIS LEVEL 3744 03:00:25,260 --> 03:00:27,229 WHEN YOU DO THE LABEL TRANSFER 3745 03:00:27,229 --> 03:00:28,864 YOU CAN IDENTIFY THE CELL TYPES 3746 03:00:28,864 --> 03:00:31,900 YOU EXPECT TO FIND IN THE GLANDS 3747 03:00:31,900 --> 03:00:34,302 AND CAN ENUMERATE OR 3748 03:00:34,302 --> 03:00:35,904 CHARACTERIZE DIFFERENT AREAS OF 3749 03:00:35,904 --> 03:00:38,974 THE GLAND INCLUDING AS YOU'D 3750 03:00:38,974 --> 03:00:47,048 EXPECT TO SEE THE TERTIARY 3751 03:00:47,048 --> 03:00:50,952 LYMPHOID STRUCTURE NOT FOUND IN 3752 03:00:50,952 --> 03:00:54,089 THIS EXAMPLE OF A NON-SJOGREN'S 3753 03:00:54,089 --> 03:00:56,958 DISEASE PATIENT AND TO FURTHER 3754 03:00:56,958 --> 03:00:57,926 SHOWCASE THE XENIUM PANEL WE 3755 03:00:57,926 --> 03:00:59,895 PLANNED TO USE FOR THE DOWN 3756 03:00:59,895 --> 03:01:02,764 STREAM ANALYSES WE'RE GOING TO 3757 03:01:02,764 --> 03:01:04,933 DO IN STAMP AND THE MULTIPLE 3758 03:01:04,933 --> 03:01:07,102 DISEASE TEAMS, HERE WE USED THE 3759 03:01:07,102 --> 03:01:10,005 SAME APPROACH TO TRANSFER LABELS 3760 03:01:10,005 --> 03:01:13,542 TO THAT 5K. 3761 03:01:13,542 --> 03:01:20,749 THE AND WHETHER WE'RE USING A 3762 03:01:20,749 --> 03:01:21,716 480K AS LONG AS THERE'S MARKERS 3763 03:01:21,716 --> 03:01:23,919 IN THE DATA SET. 3764 03:01:23,919 --> 03:01:30,325 WE THEN TOOK THE MARKERS TOOK 3765 03:01:30,325 --> 03:01:31,726 THE PHENOTYPES PUTTING THEM IN 3766 03:01:31,726 --> 03:01:33,361 THE EXPLORER AND THIS IS 3767 03:01:33,361 --> 03:01:37,032 SOMETHING WHERE CLINICIANS OR 3768 03:01:37,032 --> 03:01:40,502 SCIENTISTS CAN DO THE JOB THAT 3769 03:01:40,502 --> 03:01:41,803 PATHOLOGISTS USED TO DO AT 3770 03:01:41,803 --> 03:01:44,139 HIGHER RESOLUTION AND SHOW 3771 03:01:44,139 --> 03:01:44,940 RELATIONSHIPS BETWEEN SPECIFIC 3772 03:01:44,940 --> 03:01:47,676 CELLS YOU MIGHT BE INTERESTED 3773 03:01:47,676 --> 03:01:52,414 AND HEAR THEM HIGHLIGHTING CD4 B 3774 03:01:52,414 --> 03:01:58,053 CELL INTERACT IN THE CELL AND 3775 03:01:58,053 --> 03:01:59,454 HIGHLIGHTS THE HETEROGENEITY 3776 03:01:59,454 --> 03:02:01,456 WITHIN THE EPITHELIAL 3777 03:02:01,456 --> 03:02:03,358 COMPARTMENT WHICH IS REMARKABLE 3778 03:02:03,358 --> 03:02:05,227 ONCE WE IDENTIFIED THE CELL TYPE 3779 03:02:05,227 --> 03:02:07,662 AND LOOK AT RELATIONSHIPS 3780 03:02:07,662 --> 03:02:11,900 BETWEEN CELL TYPE AND TISSUES 3781 03:02:11,900 --> 03:02:15,003 COLLECTED USING THE XENIUM TASK 3782 03:02:15,003 --> 03:02:19,908 FORCE AND LOOKING AT THE 3783 03:02:19,908 --> 03:02:26,147 MULTIPLEX IMAGING DATA A MACHINE 3784 03:02:26,147 --> 03:02:27,916 LEARNING DAIT FOR CELL TYPES AND 3785 03:02:27,916 --> 03:02:30,986 REGIONS OF THE TISSUES ENRICHED 3786 03:02:30,986 --> 03:02:33,388 FOR IMMUNE CELL TYPES AND YOU 3787 03:02:33,388 --> 03:02:37,425 CAN SEE THERE'S ENRICHMENT FOR T 3788 03:02:37,425 --> 03:02:40,595 AND B CELLS AND REGIONS JUST 3789 03:02:40,595 --> 03:02:43,098 ENRICHED FOR T CELLS. 3790 03:02:43,098 --> 03:02:45,500 YOU CAN USE OTHER THIRD-PARTY 3791 03:02:45,500 --> 03:02:47,269 APPLICATIONS APPLIED IN THE 3792 03:02:47,269 --> 03:02:49,938 SPATIAL CONTEXT TO THESE TO 3793 03:02:49,938 --> 03:02:50,739 UNDERSTAND THE COMPOSITION OF 3794 03:02:50,739 --> 03:02:53,808 THE NEIGHBORHOODS AND 3795 03:02:53,808 --> 03:02:58,246 NEIGHBORHOODS THAT ARE PUNIT 3796 03:02:58,246 --> 03:03:01,149 PUNITIVELY DRUGGABLE POTENTIALLY 3797 03:03:01,149 --> 03:03:03,251 AND CAN USE THIRD-PARTY 3798 03:03:03,251 --> 03:03:07,255 APPLICATIONS TO PREDICT DRUG 3799 03:03:07,255 --> 03:03:08,590 TARGETS AND CELLS THAT MAY BE 3800 03:03:08,590 --> 03:03:10,425 RESPONSIVE TO THE DRUGS. 3801 03:03:10,425 --> 03:03:12,727 I'M SHOWING THE SAME INFILTRATE 3802 03:03:12,727 --> 03:03:13,728 WITH THE TACIT PREDICTION OF 3803 03:03:13,728 --> 03:03:17,465 CELL TYPES. 3804 03:03:17,465 --> 03:03:23,905 AND THIS DRUG TO CELL PIPELINE 3805 03:03:23,905 --> 03:03:34,416 THAT DERIVED A SEMI SELECTED 3806 03:03:39,487 --> 03:03:42,958 JAK1 AND 3 AND WAS PREDICTED TO 3807 03:03:42,958 --> 03:03:45,894 BE USEFUL IN SJOGREN'S DISEASE 3808 03:03:45,894 --> 03:03:47,262 AND UNDER INVESTIGATION BY THE 3809 03:03:47,262 --> 03:03:49,864 TEAM AND NOT ONLY THAT CAN YOU 3810 03:03:49,864 --> 03:03:51,900 THEN TAKE THIS DATA AND LOOK AT 3811 03:03:51,900 --> 03:03:53,168 INDIVIDUAL CELL TYPES LIKELY TO 3812 03:03:53,168 --> 03:03:55,904 RESPOND AND WHY THIS IS 3813 03:03:55,904 --> 03:04:01,242 IMPORTANT IS IT WOULD ENABLE 3814 03:04:01,242 --> 03:04:02,677 TEMPORAL ANALYSIS OF THESE 3815 03:04:02,677 --> 03:04:04,679 IMMUNE IN FILL TRIAL THEED 3816 03:04:04,679 --> 03:04:11,553 BIASES TAKEN OVER TIME SUCH AS 3817 03:04:11,553 --> 03:04:16,758 FOLLOW-UP DATA AND THE OTHER 3818 03:04:16,758 --> 03:04:19,694 BENEFIT OF THE 5K XENIUM PANEL 3819 03:04:19,694 --> 03:04:22,130 IS IT'S NON DESTRUCTIVE AND 3820 03:04:22,130 --> 03:04:23,798 ALLOWS FOR WORK FLOW. 3821 03:04:23,798 --> 03:04:25,800 THIS WAS PIONEERED BY CALEB 3822 03:04:25,800 --> 03:04:30,171 MARLIN TO PERFORM SPATIAL 3823 03:04:30,171 --> 03:04:37,012 TRANSCRIPT OMICS AND STAIN THIS 3824 03:04:37,012 --> 03:04:43,251 AND CAPTURE WHAT IS USED FOR 3825 03:04:43,251 --> 03:04:47,055 DOWN STREAM A.I. BASED TISSUE 3826 03:04:47,055 --> 03:04:51,893 ALGORITHMS AND IMAGING CYTOMETRY 3827 03:04:51,893 --> 03:04:55,797 AND USE ANTIBODIES WITH MEDALS 3828 03:04:55,797 --> 03:04:59,901 AND THE METALS CAN BE CLEAVED 3829 03:04:59,901 --> 03:05:04,372 AND WAQUANTIFIED HERE ON THE SA 3830 03:05:04,372 --> 03:05:07,909 CELLS YOU CAN COMBINE GROUND 3831 03:05:07,909 --> 03:05:08,376 TRUTH WITH DISCOVERY. 3832 03:05:08,376 --> 03:05:10,645 AND HERE I'M SHOWING THE 3833 03:05:10,645 --> 03:05:10,879 EXAMPLE. 3834 03:05:10,879 --> 03:05:19,654 HERE WE HAVE SINGLE CELL 3835 03:05:19,654 --> 03:05:21,056 TRANSFER AND SEE THE HISTOLOGY 3836 03:05:21,056 --> 03:05:24,759 AND OVERLAID ON THE DATA SET AND 3837 03:05:24,759 --> 03:05:26,327 REGISTERED TO THAT DATA SET YOU 3838 03:05:26,327 --> 03:05:34,602 CAN PERFORM THE PROTEOMICS. 3839 03:05:34,602 --> 03:05:36,271 TRANSCRIPTOMIC I'D FINDS 3840 03:05:36,271 --> 03:05:37,739 CELLULAR NEIGHBORHOODS, 3841 03:05:37,739 --> 03:05:40,675 SIGNALLING AND DRUGGABLE NICHES 3842 03:05:40,675 --> 03:05:42,710 AND TISSUES USED TO PREDICT OR 3843 03:05:42,710 --> 03:05:47,182 MONITOR THERAPEUTIC RESPONSES IN 3844 03:05:47,182 --> 03:05:50,185 SITU AND MULTI-MODAL WORK FLOWS 3845 03:05:50,185 --> 03:05:51,653 ARE WITHIN REACH AND GROUND 3846 03:05:51,653 --> 03:05:52,654 TRUTH NEEDS DISCOVERY. 3847 03:05:52,654 --> 03:05:57,125 THE INVESTIGATIVE DIRECTION IS 3848 03:05:57,125 --> 03:06:00,829 ENABLED BY MATCHED SINGLE CELL 3849 03:06:00,829 --> 03:06:01,396 OMICS TECHNOLOGY DISCUSSED 3850 03:06:01,396 --> 03:06:11,539 FURTHER. 3851 03:06:11,973 --> 03:06:22,083 THANK YOU. 3852 03:06:23,618 --> 03:06:29,257 >> MY NAME IS CHRIS LESSARD A 3853 03:06:29,257 --> 03:06:31,359 PROFESSOR AT THE RESEARCH 3854 03:06:31,359 --> 03:06:32,760 FOUNDATION AND TELL YOU ABOUT 3855 03:06:32,760 --> 03:06:40,735 OUR STUDY ON SINGLE CELL 3856 03:06:40,735 --> 03:06:41,269 TECHNOLOGIES. 3857 03:06:41,269 --> 03:06:42,370 TO START OFF I WANT TO GIVE OVER 3858 03:06:42,370 --> 03:06:44,906 THE STATE OF WHERE WE'RE AT 3859 03:06:44,906 --> 03:06:50,311 SINCE THE NETWORK KICKED OFF. 3860 03:06:50,311 --> 03:06:56,718 BOTH GROUPS HERE ARE 3861 03:06:56,718 --> 03:06:57,352 DISAGGREGATED TISSUE FROM 3862 03:06:57,352 --> 03:07:02,357 SALIVARY GLANDS BUT WE'VE DONE 3863 03:07:02,357 --> 03:07:06,861 THIS AFTER THEY WERE TAKEN AND 3864 03:07:06,861 --> 03:07:09,364 WE NEEDED TO PILOT THAT OUT TO 3865 03:07:09,364 --> 03:07:11,933 MAKE SURE WE WEREN'T GOING TO 3866 03:07:11,933 --> 03:07:14,569 SEE ANYTHING DIFFERENT FROM 3867 03:07:14,569 --> 03:07:17,772 BEFORE IN THE FREEZING AND DYING 3868 03:07:17,772 --> 03:07:22,777 OF THE TISSUE AND IMPACT THE 3869 03:07:22,777 --> 03:07:24,946 DOWN STREAM AND UNDERSTAND HOW 3870 03:07:24,946 --> 03:07:31,085 WE SPENT TIME DEVELOPING A 3871 03:07:31,085 --> 03:07:34,522 PROTOCOL AS WELL AS MERGING THE 3872 03:07:34,522 --> 03:07:35,523 PROCESS. 3873 03:07:35,523 --> 03:07:39,928 THERE WAS A NEW CHEMISTRY 3874 03:07:39,928 --> 03:07:41,362 INTRIGUING TO US WITH SINGLE 3875 03:07:41,362 --> 03:07:41,696 CELL FLEX. 3876 03:07:41,696 --> 03:07:49,137 THIS ALLOWED US TO USE FIXED 3877 03:07:49,137 --> 03:07:52,907 SAMPLES AND DISEASE DESCRIBED 3878 03:07:52,907 --> 03:07:53,508 EARLIER. 3879 03:07:53,508 --> 03:08:00,481 WE GOT EARLY ACCESS TO A 3880 03:08:00,481 --> 03:08:02,050 PRE-RELEASED PROTOCOL. 3881 03:08:02,050 --> 03:08:04,452 IT CALLED FOR A 225 MICRON 3882 03:08:04,452 --> 03:08:05,753 SESSION TO BE USED. 3883 03:08:05,753 --> 03:08:07,889 THAT'S WAY TOO MUCH TISSUE FOR 3884 03:08:07,889 --> 03:08:10,325 THE USE IN AMP AIM FOR TISSUES 3885 03:08:10,325 --> 03:08:13,528 LIKE THE KIDNEY SAMPLES BEING 3886 03:08:13,528 --> 03:08:18,600 TAKEN IN NEEDLE BIOPSIES. 3887 03:08:18,600 --> 03:08:21,002 WE SPENT TO THE FIRST HALF OF 3888 03:08:21,002 --> 03:08:26,441 2023 MODIFYING THE PROTOCOL AND 3889 03:08:26,441 --> 03:08:28,843 ABLE TO USE 125 MICROON SESSION 3890 03:08:28,843 --> 03:08:30,345 AND CAPTURING THOUSANDS OF CELLS 3891 03:08:30,345 --> 03:08:31,012 PER SUBJECT. 3892 03:08:31,012 --> 03:08:35,016 THE WORK FLOW IS DESCRIBED HERE 3893 03:08:35,016 --> 03:08:36,351 WE DISAGGREGATE TISSUE ON THE 3894 03:08:36,351 --> 03:08:39,053 SYSTEM AND THEN THE SAMPLES ARE 3895 03:08:39,053 --> 03:08:43,558 THEN PROBED AND HYBRIDIZED IN AN 3896 03:08:43,558 --> 03:08:50,999 OVERNIGHT STEP AND UNIQUELY 3897 03:08:50,999 --> 03:08:56,137 LABELLED. 3898 03:08:56,137 --> 03:08:58,172 THE SEQUENCING CAPTURES MOLES 3899 03:08:58,172 --> 03:08:58,806 PRESENT IN THE CELL. 3900 03:08:58,806 --> 03:09:02,010 ONE OF THE BIGGEST BENEFITS 3901 03:09:02,010 --> 03:09:03,611 THAT'S HARD TO APPRECIATE NOT 3902 03:09:03,611 --> 03:09:06,914 ONLY CAN WE DO SINGLE CELL WORK 3903 03:09:06,914 --> 03:09:10,218 BUT CAN DO THE COMPLEX OF THE 3904 03:09:10,218 --> 03:09:12,854 EMBEDDED TISSUE AND DO OTHER 3905 03:09:12,854 --> 03:09:14,555 DOWN STREAM PLATFORMS. 3906 03:09:14,555 --> 03:09:18,293 THERE'S PROS AND CONS TO 3907 03:09:18,293 --> 03:09:18,960 DIFFERENT PLATFORMS AVAILABLE TO 3908 03:09:18,960 --> 03:09:21,262 DO SINGLE CELL TECHNOLOGIES. 3909 03:09:21,262 --> 03:09:24,532 SOME ARE FIXED TISSUE BEING USED 3910 03:09:24,532 --> 03:09:26,567 IN THE OTHER ASSAYS. 3911 03:09:26,567 --> 03:09:28,436 THESE ARE HOMOGENIZED ACROSS 3912 03:09:28,436 --> 03:09:30,638 SITES AND SURVIVORSHIP BIAS IS 3913 03:09:30,638 --> 03:09:32,907 AN EXTREME PROBLEM WITH THE 3914 03:09:32,907 --> 03:09:35,043 ASSAYS WE'LL TOUCH ON WHEN I 3915 03:09:35,043 --> 03:09:35,510 SHOW YOU DATA. 3916 03:09:35,510 --> 03:09:40,815 BY AND LARGE THE BIGGEST BENEFIT 3917 03:09:40,815 --> 03:09:43,418 IS YOU CAN USE THE XENIUM 3918 03:09:43,418 --> 03:09:44,986 PLATFORM AND THE SAME PROBES 3919 03:09:44,986 --> 03:09:46,020 BETWEEN TECHNOLOGY. 3920 03:09:46,020 --> 03:09:47,822 THERE'S ONLY 18,000 PROBES. 3921 03:09:47,822 --> 03:09:51,559 IT DOES NOT COVER THE ENTIRE 3922 03:09:51,559 --> 03:09:51,893 GENOME. 3923 03:09:51,893 --> 03:09:57,031 IT DOES NOT ALLOW FOR THE 3924 03:09:57,031 --> 03:09:59,901 REPERTOIRE OR SEQ ANALYSIS 3925 03:09:59,901 --> 03:10:00,468 TALKED ABOUT IN THE SPATIAL 3926 03:10:00,468 --> 03:10:02,203 CONTEXT. 3927 03:10:02,203 --> 03:10:04,405 SO BEFORE WE STARTED RECRUITING, 3928 03:10:04,405 --> 03:10:06,908 BLAKE WAS GENEROUS ENOUGH AT HIS 3929 03:10:06,908 --> 03:10:09,644 GROUP AND THE INTRAMURAL PROGRAM 3930 03:10:09,644 --> 03:10:11,479 TO COLLECT SAMPLES FROM HEALTHY 3931 03:10:11,479 --> 03:10:14,982 SUBJECTS TO CAPTURE ALL THE CRYO 3932 03:10:14,982 --> 03:10:18,519 PRESERVATION AND TISSUE WE NEED 3933 03:10:18,519 --> 03:10:19,754 TO PILOT THIS AS WELL AS 3934 03:10:19,754 --> 03:10:23,324 CAPTURING DATA TO DO THAT DIRECT 3935 03:10:23,324 --> 03:10:23,624 COMPARISON. 3936 03:10:23,624 --> 03:10:24,325 WE'LL TALK ABOUT THE DATA 3937 03:10:24,325 --> 03:10:27,895 BECAUSE IT WAS THE SAME AS THE 3938 03:10:27,895 --> 03:10:32,367 CRYO PRESERVED DATA I'LL TALK 3939 03:10:32,367 --> 03:10:33,968 ABOUT IN A MINUTE. 3940 03:10:33,968 --> 03:10:36,604 THIS SUMMARIZES THE INITIAL 3941 03:10:36,604 --> 03:10:38,606 PILOT AND WHERE THEY'RE 3942 03:10:38,606 --> 03:10:40,575 SEQUENCING BASED APPROACHES FROM 3943 03:10:40,575 --> 03:10:42,744 DIFFERENT ENDS OF THE RNA 3944 03:10:42,744 --> 03:10:43,611 MOLECULE. 3945 03:10:43,611 --> 03:10:44,779 BECAUSE THE APPROACH IS PROBE 3946 03:10:44,779 --> 03:10:47,181 BASED I THINK THE NETWORK WAS 3947 03:10:47,181 --> 03:10:48,116 CONCERNED ABOUT THE LOSS OF 3948 03:10:48,116 --> 03:10:53,454 GENES PER CELL AND SAW GOOD 3949 03:10:53,454 --> 03:10:55,590 AGREEMENT IF YOU LOOK APT THE 3950 03:10:55,590 --> 03:10:57,191 FEATURES OR GENES PER CELL I'M 3951 03:10:57,191 --> 03:10:59,427 SHOWING ON THE LEFT SIDE OF THE 3952 03:10:59,427 --> 03:11:00,995 SLIDE THEY'RE FAIRLY SIMILAR. 3953 03:11:00,995 --> 03:11:05,299 AND THIS IS AA WELL KNOWN 3954 03:11:05,299 --> 03:11:07,402 DIFFERENCE BETWEEN THE THREE 3955 03:11:07,402 --> 03:11:10,638 PRIME AND FIVE PRIME MORE GENES 3956 03:11:10,638 --> 03:11:13,141 PER CELL THOUGH NOT IDENTICAL 3957 03:11:13,141 --> 03:11:15,009 IT'S SIMILAR AND THE NET WORK 3958 03:11:15,009 --> 03:11:16,778 WAS EXCITED ABOUT THE RESULTS 3959 03:11:16,778 --> 03:11:18,246 AND THE TECHNOLOGY MOVING 3960 03:11:18,246 --> 03:11:18,479 FORWARD. 3961 03:11:18,479 --> 03:11:20,848 I THINK ONE OF THE MOST 3962 03:11:20,848 --> 03:11:23,918 INTERESTING FINDINGS WAS THE 3963 03:11:23,918 --> 03:11:26,988 FACT THAT WE DID SEE EXTREME 3964 03:11:26,988 --> 03:11:27,889 SURVIVORSHIP BIAS. 3965 03:11:27,889 --> 03:11:32,960 WE HAVE THREE COLORS AND GREEN 3966 03:11:32,960 --> 03:11:35,730 IS FIVE PRIME AND RED IS THREE 3967 03:11:35,730 --> 03:11:35,930 PRIME. 3968 03:11:35,930 --> 03:11:39,667 WHEN YOU LOOK AT PERCENT OF 3969 03:11:39,667 --> 03:11:43,571 CELLS ACROSS THE BOARD MOST 3970 03:11:43,571 --> 03:11:47,909 REGIONS OF THE GLAND THE CELLS 3971 03:11:47,909 --> 03:11:49,610 BEING COUNTED IN THE SINGLE CELL 3972 03:11:49,610 --> 03:11:51,913 APPROACH AND THERE'S OTHER 3973 03:11:51,913 --> 03:11:54,482 SUBSETS MAKE IDENTIFIED IN THE 3974 03:11:54,482 --> 03:11:59,987 WORK THEY ARE DIDN'T LOOK LIKE 3975 03:11:59,987 --> 03:12:02,056 THEY ARE CAPTURED AS WELL AND 3976 03:12:02,056 --> 03:12:03,891 THERE MIGHT BE TRANSLATABILITY 3977 03:12:03,891 --> 03:12:04,525 DIFFERENCE BETWEEN THE PROBES 3978 03:12:04,525 --> 03:12:08,062 AND TECHNOLOGIES WE NEED TO 3979 03:12:08,062 --> 03:12:08,663 EXPLORE FURTHER. 3980 03:12:08,663 --> 03:12:11,299 IT WASN'T ONLY THE EPITHELIAL 3981 03:12:11,299 --> 03:12:14,268 CELLS WE SEE MORE MACROPHAGES 3982 03:12:14,268 --> 03:12:18,706 AND PLASMA CELLS AND MORE 3983 03:12:18,706 --> 03:12:20,675 DENDRITIC CELLS AND B CELLS. 3984 03:12:20,675 --> 03:12:23,177 IT WAS NICE TO SEE WE'LL GET 3985 03:12:23,177 --> 03:12:25,179 BETTER REPRESENTATION OF THE 3986 03:12:25,179 --> 03:12:30,084 DIVERSE CELL TYPES WE COULD 3987 03:12:30,084 --> 03:12:34,622 EXPECT TO SEE IN THE 3988 03:12:34,622 --> 03:12:35,189 PATHOGENESIS OF SJOGREN'S 3989 03:12:35,189 --> 03:12:38,693 DISEASE AND WE FOCUSSED ON 3990 03:12:38,693 --> 03:12:39,627 POSITIVE SJOGREN'S AND WERE ABLE 3991 03:12:39,627 --> 03:12:44,999 TO TRANSFER LABELS FROM MAKE'S 3992 03:12:44,999 --> 03:12:46,701 ORIGINAL 90,000 K DATA SET AND 3993 03:12:46,701 --> 03:12:48,503 WERE ABLE TO FIND ALMOST ALL THE 3994 03:12:48,503 --> 03:12:49,136 CELL POPULATIONS ACROSS THE DATA 3995 03:12:49,136 --> 03:12:54,742 SET. 3996 03:12:54,742 --> 03:12:57,178 IMMUNE CELLS WERE HIGHLY 3997 03:12:57,178 --> 03:12:59,747 REPRESENTED IN THE SJOGREN'S 3998 03:12:59,747 --> 03:13:01,382 PATIENTS AND WE USED A LONG 3999 03:13:01,382 --> 03:13:05,019 KNOWN ALGORITHM THAT USES A.I. 4000 03:13:05,019 --> 03:13:07,221 DEVELOPED IN THE U.K. WHERE IT A 4001 03:13:07,221 --> 03:13:10,424 DEEP DATA SET TO BE ABLE TO 4002 03:13:10,424 --> 03:13:11,058 INTERROGATE THE DATA SET TO FIND 4003 03:13:11,058 --> 03:13:14,996 THE CELL TYPES. 4004 03:13:14,996 --> 03:13:17,031 AND AS YOU'D EXPECT WE'D WANT TO 4005 03:13:17,031 --> 03:13:25,406 TO SEE THE DOMINATION OF IMMUNE 4006 03:13:25,406 --> 03:13:32,313 CELLS IN THE SALIVARY GLANDS AND 4007 03:13:32,313 --> 03:13:34,115 HERE'S SHOWING SOME IMMUNE CELL 4008 03:13:34,115 --> 03:13:34,415 SUBSETS. 4009 03:13:34,415 --> 03:13:37,051 ONE OF THE BIGGEST INCREASES IN 4010 03:13:37,051 --> 03:13:39,186 NUMBER WE WERE ABLE TO IDENTIFY 4011 03:13:39,186 --> 03:13:41,255 WITH THE PLASMA CELLS AND SEE A 4012 03:13:41,255 --> 03:13:42,790 LARGE NUMBER OF THEM WE'RE ABLE 4013 03:13:42,790 --> 03:13:44,759 TO PULL OUT AND ALL THESE MAJOR 4014 03:13:44,759 --> 03:13:46,928 CELL TYPE POPULATIONS WE WERE 4015 03:13:46,928 --> 03:13:48,529 ABLE TO IDENTIFY INCLUDING SOME 4016 03:13:48,529 --> 03:13:53,935 THAT I THINK THAT ARE MORE 4017 03:13:53,935 --> 03:13:57,004 REFINED AND OTHERS THAT MAY BE 4018 03:13:57,004 --> 03:13:58,773 IMPORTANT THAT IMPACT 4019 03:13:58,773 --> 03:13:59,106 PHYSIOLOGY. 4020 03:13:59,106 --> 03:14:01,742 EXCITED ABOUT OUR ABILITY TO 4021 03:14:01,742 --> 03:14:05,980 CAPTURE IMMUNE CELLS SUBSETS IN 4022 03:14:05,980 --> 03:14:09,517 THE DATA WITHOUT HAVING ANTIBODY 4023 03:14:09,517 --> 03:14:10,651 TAGS FOR ANALYSIS. 4024 03:14:10,651 --> 03:14:12,920 IN WORKING WITH BLAKE WE DECIDED 4025 03:14:12,920 --> 03:14:16,991 TO DIVE DEEPER IN THE SINGLE 4026 03:14:16,991 --> 03:14:21,329 CELL NON-IMMUNE COMPARTMENTS AND 4027 03:14:21,329 --> 03:14:23,764 ANNOTATE THIS DATA TO GIVE 4028 03:14:23,764 --> 03:14:25,499 BETTER IDEA OF WHAT SUBSETS 4029 03:14:25,499 --> 03:14:27,401 WE'RE SEEING AND I WANT TO SAY 4030 03:14:27,401 --> 03:14:31,806 ONE OF THE BIGGEST ADVANTAGES OF 4031 03:14:31,806 --> 03:14:35,576 THE SINGLE CELL FLP IS HOW CLEAN 4032 03:14:35,576 --> 03:14:37,979 IT IS AND WE'VE SEEN 4033 03:14:37,979 --> 03:14:43,884 CONTAMINATION ACROSS CELL TYPES 4034 03:14:43,884 --> 03:14:48,756 AND DISTRACTION MAKING IT 4035 03:14:48,756 --> 03:14:50,257 DIFFICULT SHOWN IN THE DARK 4036 03:14:50,257 --> 03:14:50,992 CLOUD. 4037 03:14:50,992 --> 03:14:53,260 AND LIKE YOU'D EXPECT TO SEE 4038 03:14:53,260 --> 03:14:55,296 INCREASED INFLAMMATORY CELLS WE 4039 03:14:55,296 --> 03:15:00,568 EXPECT TO SEE MORE GLANDULAR 4040 03:15:00,568 --> 03:15:04,639 CELLS IN THE CONTROLS AND SEE 4041 03:15:04,639 --> 03:15:05,139 MORE. 4042 03:15:05,139 --> 03:15:08,476 WE TRIED TO DO A DIFFERENT 4043 03:15:08,476 --> 03:15:10,511 ANALYSIS AND WERE VERY 4044 03:15:10,511 --> 03:15:10,845 UNDERPOWERED. 4045 03:15:10,845 --> 03:15:11,479 NOTHING PATCHED THE THRESHOLD 4046 03:15:11,479 --> 03:15:15,016 BUT IT'S IMPORTANT TO LOOK AT 4047 03:15:15,016 --> 03:15:15,916 BECAUSE THERE ARE THINGS IN 4048 03:15:15,916 --> 03:15:17,551 SJOGREN'S DISEASE PATIENTS WE 4049 03:15:17,551 --> 03:15:18,919 EXPECT TO SEE. 4050 03:15:18,919 --> 03:15:20,955 I'M GOING TO HIGHLIGHT A FEW. 4051 03:15:20,955 --> 03:15:24,892 IT'S BUSY TO SEE BUT WE DO SEE 4052 03:15:24,892 --> 03:15:26,794 THE TYPE 1 INTERFERON SIGNALLING 4053 03:15:26,794 --> 03:15:30,464 SHOWING UP AS THE PATHWAY IN THE 4054 03:15:30,464 --> 03:15:32,700 IMMUNE CELL SUBSET AND GLANDULAR 4055 03:15:32,700 --> 03:15:33,834 CELLS AND DOWN REGULATION OF THE 4056 03:15:33,834 --> 03:15:39,874 ENZYME A WE KNOW FROM OTHER 4057 03:15:39,874 --> 03:15:41,609 PREVIOUS AMP WORK. 4058 03:15:41,609 --> 03:15:43,911 AND INCREASED K CELLS. 4059 03:15:43,911 --> 03:15:54,455 WE SEE A MIXED BACK IN AUTOPHAGY 4060 03:15:56,057 --> 03:15:58,492 AND SEE ALTERNATIVE ACTION 4061 03:15:58,492 --> 03:16:02,363 APPROACHES WITH THE MACRO 4062 03:16:02,363 --> 03:16:05,733 FATHERS AS WELL AS NEUTROPHIL 4063 03:16:05,733 --> 03:16:07,368 DEGRADATION SHOWING IMPORTANCE 4064 03:16:07,368 --> 03:16:07,902 IN B CELLS. 4065 03:16:07,902 --> 03:16:11,072 WE'RE EXCITED ABOUT THE INITIAL 4066 03:16:11,072 --> 03:16:13,274 RESULTS AND PLEASED MOVING 4067 03:16:13,274 --> 03:16:14,809 FORWARD IN THE EARLY DISEASE 4068 03:16:14,809 --> 03:16:20,347 PROJECT CAROLINE DESCRIBED AS 4069 03:16:20,347 --> 03:16:25,219 THE SINGLE CELL FFP WITH THE 4070 03:16:25,219 --> 03:16:31,625 SITES TO GET THE B CELL, C CELL 4071 03:16:31,625 --> 03:16:34,562 REPERTOIRE AND THE CELL TYPES IN 4072 03:16:34,562 --> 03:16:36,864 THE TISSUE AS WELL AS THE WORK 4073 03:16:36,864 --> 03:16:38,966 FLOW FOR THE PLATFORMS AND OTHER 4074 03:16:38,966 --> 03:16:41,202 TECHNOLOGIES THAT WE'LL BE USED 4075 03:16:41,202 --> 03:16:43,604 IN COMBINATION FOR THIS AND THE 4076 03:16:43,604 --> 03:16:45,139 NETWORK SELECTED TO DO THE WORK. 4077 03:16:45,139 --> 03:16:48,175 REALLY EXCITED ABOUT THAT. 4078 03:16:48,175 --> 03:16:49,977 I WANT TO THANK EVERYBODY IN MY 4079 03:16:49,977 --> 03:16:53,814 LAB AND COLLABORATORS THAT 4080 03:16:53,814 --> 03:16:55,316 PARTICIPATED AND THOSE FOR ALL 4081 03:16:55,316 --> 03:16:57,351 THEIR HARD WORK IN THIS AND THE 4082 03:16:57,351 --> 03:16:58,619 NETWORK BECAUSE WITHOUT THEM 4083 03:16:58,619 --> 03:17:00,054 THIS WOULDN'T BE GOING ANYWHERE 4084 03:17:00,054 --> 03:17:05,926 AND THE NET WORK PRIMARY 4085 03:17:05,926 --> 03:17:16,303 INVESTIGATORS FROM EACH SITE AND 4086 03:17:16,303 --> 03:17:25,346 THE FNI H WHO PRIMM MED -- WHO 4087 03:17:25,346 --> 03:17:28,015 BRIDGES TOGETHER THE STAFF AND 4088 03:17:28,015 --> 03:17:30,751 WITH THAT NEXT SARA McCOY WILL 4089 03:17:30,751 --> 03:17:31,886 TALK ABOUT HER LEADERSHIP 4090 03:17:31,886 --> 03:17:41,796 SCHOLARS PROGRAM. 4091 03:17:41,796 --> 03:17:43,464 >> HI, EVERYBODY. 4092 03:17:43,464 --> 03:17:46,000 EVERYBODY CAN SEE MY SCREEN 4093 03:17:46,000 --> 03:17:46,367 OKAY? 4094 03:17:46,367 --> 03:17:47,034 >> LOOKS GOOD. 4095 03:17:47,034 --> 03:17:48,769 >> IT'S AN HONOR TO BE HERE TO 4096 03:17:48,769 --> 03:17:54,542 SPEAK WITH YOU ABOUT THE AMP AIM 4097 03:17:54,542 --> 03:17:57,244 LEADERSHIP SCHOLARS PROGRAM PART 4098 03:17:57,244 --> 03:17:58,579 OF AMP AIM. 4099 03:17:58,579 --> 03:18:00,214 I'M SARA McCOY AT THE UNIVERSITY 4100 03:18:00,214 --> 03:18:08,989 OF WISCONSIN I RUN OUR SJOGREN'S 4101 03:18:08,989 --> 03:18:11,158 DISEASE CLINIC AND RUN A WET LAB 4102 03:18:11,158 --> 03:18:12,526 AND EXCITING TO TELL YOU ABOUT 4103 03:18:12,526 --> 03:18:13,127 THE PROGRAM. 4104 03:18:13,127 --> 03:18:16,330 WHAT WE'LL DO IS WE'LL TALK 4105 03:18:16,330 --> 03:18:21,702 ABOUT THE GAPS THE LSP WAS 4106 03:18:21,702 --> 03:18:23,571 DESIGN TO DISCUSS AND DISCUSS 4107 03:18:23,571 --> 03:18:26,273 THE LSP AND WHAT EXACTLY IT IS 4108 03:18:26,273 --> 03:18:27,908 AND THEN I'LL DIVE INTO AN 4109 03:18:27,908 --> 03:18:30,444 EXAMPLE WHICH IS OUR WORK IN AMP 4110 03:18:30,444 --> 03:18:35,015 AIM LSP DEPLOYMENT. 4111 03:18:35,015 --> 03:18:37,918 WHY DO WE HAVE THE AMP AIM LSP? 4112 03:18:37,918 --> 03:18:41,922 WELL, 80% OF FOLKS WITH AUTO 4113 03:18:41,922 --> 03:18:43,724 IMMUNE DISEASE ARE FEMALE. 4114 03:18:43,724 --> 03:18:45,292 AND SJOGREN'S DISEASE WHICH IS 4115 03:18:45,292 --> 03:18:47,328 MY PASSION AND AREA OF INTEREST 4116 03:18:47,328 --> 03:18:51,899 TO TRY TO UNDERSTAND HAS A 9-1 4117 03:18:51,899 --> 03:18:54,301 FEMALE TO MALE RATIO AND IN SOME 4118 03:18:54,301 --> 03:18:58,772 PUBLICATIONS AS HIGH AS 20-1. 4119 03:18:58,772 --> 03:19:02,243 REGARDLESS THE MOST 4120 03:19:02,243 --> 03:19:03,410 FEMALE-DOMINANT SYSTEMIC AUTO 4121 03:19:03,410 --> 03:19:04,378 IMMUNE DISEASE. 4122 03:19:04,378 --> 03:19:05,379 IF WE WANT TO UNDERSTAND THE 4123 03:19:05,379 --> 03:19:06,714 HEALTH DISPARITY AND WAYS TO 4124 03:19:06,714 --> 03:19:08,515 MITIGATE IT, WE NEED TO DEVELOP 4125 03:19:08,515 --> 03:19:10,684 A PROGRAM THAT PROMOTES 4126 03:19:10,684 --> 03:19:11,886 UNDERSTANDING THESE DIFFERENCES 4127 03:19:11,886 --> 03:19:13,520 AND THAT'S WHERE THE AMP AIM LSP 4128 03:19:13,520 --> 03:19:14,989 STEPS IN. 4129 03:19:14,989 --> 03:19:19,894 THE GOAL IS TO IMPROVE WOMEN'S 4130 03:19:19,894 --> 03:19:21,695 HEALTH WITH SCHOLARS WHO 4131 03:19:21,695 --> 03:19:23,297 SPECIALIZE IN WOMEN'S HEALTH 4132 03:19:23,297 --> 03:19:33,807 RELATED AUTO IMMUNE DISEASES. 4133 03:19:43,017 --> 03:19:46,787 IT'S TO ENHANCE SCHOLAR 4134 03:19:46,787 --> 03:19:49,189 LEADERSHIP RAND MENTORSHIP AND 4135 03:19:49,189 --> 03:19:53,761 ENCOURAGE SCIENCE AND LEVERAGE 4136 03:19:53,761 --> 03:19:57,998 THE AMP AIM RESOURCES AND 4137 03:19:57,998 --> 03:19:59,700 SYNERGIZE TO PROMOTE 4138 03:19:59,700 --> 03:20:00,935 LONGITUDINAL SCIENCE INITIATIVES 4139 03:20:00,935 --> 03:20:02,870 THAT HAVE LEGS THAT CAN LAST AND 4140 03:20:02,870 --> 03:20:05,539 LEAD TO IMPORTANT PATHOGENIC 4141 03:20:05,539 --> 03:20:06,173 INSIGHTS AND HOPEFULLY CURES FOR 4142 03:20:06,173 --> 03:20:10,577 DISEASE. 4143 03:20:10,577 --> 03:20:13,814 KNOW I'LL DIVE INTO MY AREA OF 4144 03:20:13,814 --> 03:20:15,883 INTEREST WITHIN THE FIELD. 4145 03:20:15,883 --> 03:20:18,018 I THINK STROMAL CELLS ARE REALLY 4146 03:20:18,018 --> 03:20:22,056 INTERESTING AND THIS PROJECT 4147 03:20:22,056 --> 03:20:27,628 FOCUSES ON SALIVARY GLAND 4148 03:20:27,628 --> 03:20:28,529 FIBROBLASTS A CELL TYPE. 4149 03:20:28,529 --> 03:20:33,334 THAT SAID WE DON'T KNOW THE 4150 03:20:33,334 --> 03:20:34,335 EFFECTS OF THE CHRONIC SALIVARY 4151 03:20:34,335 --> 03:20:39,006 GLAND INFLAMMATION AND THE 4152 03:20:39,006 --> 03:20:43,911 FIBROBLAST CHROMATIN AND 4153 03:20:43,911 --> 03:20:45,879 TRANSCRIPTOME AND WE STARTED THE 4154 03:20:45,879 --> 03:20:46,981 PROJECT AND FOCUS ON WHAT WE 4155 03:20:46,981 --> 03:20:47,448 DISCOVERED ABOUT THE 4156 03:20:47,448 --> 03:20:52,019 TRANSCRIPTOME SO FAR. 4157 03:20:52,019 --> 03:20:53,854 THE VERY FIRST THING I DID WHEN 4158 03:20:53,854 --> 03:20:56,824 WE US AWARDED WITH THIS AMP AIM 4159 03:20:56,824 --> 03:20:59,460 LSP IS TO SEEK OUT A REALLY 4160 03:20:59,460 --> 03:20:59,793 STRONG TEAM. 4161 03:20:59,793 --> 03:21:01,528 ONE OF THESE FACES IS GOING TO 4162 03:21:01,528 --> 03:21:04,465 BE FAMILIAR TO YOU, DR. BLAKE 4163 03:21:04,465 --> 03:21:07,201 WARNER WHO IS OUR NIDCR MENTOR 4164 03:21:07,201 --> 03:21:07,901 AND HE'S AN AMP AIM STAMP 4165 03:21:07,901 --> 03:21:13,507 MEMBER. 4166 03:21:13,507 --> 03:21:24,051 HE WORKS WITH MYSELF AND HE ALSO 4167 03:21:28,322 --> 03:21:32,559 HELPS RUN THE SYSTEMS BIOLOGY 4168 03:21:32,559 --> 03:21:38,732 CORE AND WE HAVE ALEX TSOI AIO 4169 03:21:38,732 --> 03:21:40,200 INFORMATICIAN AND HELP RUN THE 4170 03:21:40,200 --> 03:21:40,401 CORE. 4171 03:21:40,401 --> 03:21:42,770 I THOUGHT I BUILT A STRONG TEAM. 4172 03:21:42,770 --> 03:21:45,005 I'LL TALK LATER WHERE THE TEAM 4173 03:21:45,005 --> 03:21:47,908 CAN TAKE US POTENTIALLY IN THE 4174 03:21:47,908 --> 03:21:51,879 FUTURE. 4175 03:21:51,879 --> 03:21:53,247 OUR NEXT STEP WAS TO SAY LET'S 4176 03:21:53,247 --> 03:21:57,751 START ANSWERING THE QUESTIONS 4177 03:21:57,751 --> 03:21:58,018 PROPOSED. 4178 03:21:58,018 --> 03:21:59,920 I WAS FORTUNATE TO WORK WITH 4179 03:21:59,920 --> 03:22:04,324 DR. BLAKE WARNER AND SHARED THE 4180 03:22:04,324 --> 03:22:08,195 LARGEST SINGLE CELL SEQ DATA SET 4181 03:22:08,195 --> 03:22:11,899 OF SALIVARY GLANDS AND I'M FO 4182 03:22:11,899 --> 03:22:20,274 FOCUSSING ON THESE SAMPLE 15SSA 4183 03:22:20,274 --> 03:22:20,941 POSITIVE SJOGREN'S DISEASES AND 4184 03:22:20,941 --> 03:22:23,911 WE TALKED ABOUT THE DINKSS AND 4185 03:22:23,911 --> 03:22:30,617 PHENOTYPES -- DIFFERENCES AND 4186 03:22:30,617 --> 03:22:32,553 PHENOTYPES AND I WANT TO START 4187 03:22:32,553 --> 03:22:37,424 WITH A BROAD OVERVIEW OF WHAT WE 4188 03:22:37,424 --> 03:22:38,492 FOUND SO FAR. 4189 03:22:38,492 --> 03:22:41,361 HERE'S A MAP SHOWING THE GENES 4190 03:22:41,361 --> 03:22:43,664 BETWEEN THE SSA POSITIVE 4191 03:22:43,664 --> 03:22:45,466 SJOGREN'S DISEASE AND CONTROLS. 4192 03:22:45,466 --> 03:22:47,501 IF WE FOCUS IN ON THE FIBER ROW 4193 03:22:47,501 --> 03:22:48,469 BLAST POPULATIONS WHAT I THINK 4194 03:22:48,469 --> 03:22:51,905 IS INTERESTING IS THE AMOUNT OF 4195 03:22:51,905 --> 03:22:52,539 DIFFERENTIALLY EXPRESSED GENES 4196 03:22:52,539 --> 03:22:56,977 IS AKIN TO THAT OF MYELOID CELL 4197 03:22:56,977 --> 03:22:59,880 WITH A KNOWN ROLE IN SJOGREN'S 4198 03:22:59,880 --> 03:23:01,281 DISEASE PATHOGENESIS. 4199 03:23:01,281 --> 03:23:04,852 WHEN WE FOCUS ON THE MOST 4200 03:23:04,852 --> 03:23:14,228 DIFFERENTLY EXPRESSED GENES FIBE 4201 03:23:14,228 --> 03:23:19,900 -- FIBROBLASTS AS A CELL TYPE 4202 03:23:19,900 --> 03:23:23,904 OF INTEREST. 4203 03:23:23,904 --> 03:23:25,272 THE OTHER REASON WE FOUND THEM 4204 03:23:25,272 --> 03:23:27,007 COMPELLING IS THEY'RE EXPANDING. 4205 03:23:27,007 --> 03:23:29,176 HERE ON THE RIGHT SIDE YOU CAN 4206 03:23:29,176 --> 03:23:35,849 SEE FIBROBLASTS IN BROWN THE SSA 4207 03:23:35,849 --> 03:23:39,453 POSIT 4208 03:23:39,453 --> 03:23:39,987 POSIT 4209 03:23:39,987 --> 03:23:41,922 POSITIVE SJOGREN'S DISEASE 4210 03:23:41,922 --> 03:23:45,325 PATIENTS AND NON-SJOGREN'S. 4211 03:23:45,325 --> 03:23:49,296 WE DON'T SEE AS MUCH IN THE 4212 03:23:49,296 --> 03:23:54,234 EPITHELIAL POPULATION AND 4213 03:23:54,234 --> 03:23:57,037 THERE'S CONTRACTION OF 4214 03:23:57,037 --> 03:23:57,771 EPITHELIAL CELLS IN SJOGREN'S 4215 03:23:57,771 --> 03:23:58,272 DISEASE. 4216 03:23:58,272 --> 03:24:01,308 SO GETTING MORE INTO THE FUN 4217 03:24:01,308 --> 03:24:01,508 STUFF. 4218 03:24:01,508 --> 03:24:04,211 WHAT IS DIFFERENT ABOUT THESE 4219 03:24:04,211 --> 03:24:06,180 FIBROBLASTS IN SJOGREN'S DISEASE 4220 03:24:06,180 --> 03:24:06,980 COMPARED TO NONE? 4221 03:24:06,980 --> 03:24:09,950 LET'S LEARN A LITTLE BIT ABOUT 4222 03:24:09,950 --> 03:24:10,617 IT. 4223 03:24:10,617 --> 03:24:13,554 THE RIBOSOMAL TRANSCRIPTS ARE UP 4224 03:24:13,554 --> 03:24:15,155 REGULATED IN SJOGREN'S COMPARED 4225 03:24:15,155 --> 03:24:18,692 TO CONTROLS AND TGF BETA 4226 03:24:18,692 --> 03:24:22,129 TRANSCRIPTS ARE DOWN REGULATED 4227 03:24:22,129 --> 03:24:23,864 COMPARED TO SJOGREN'S CONTROLS. 4228 03:24:23,864 --> 03:24:29,736 WE ALSO SEE A NICE TREND OF 4229 03:24:29,736 --> 03:24:30,938 INTERFERON TRANSCRIPTS 4230 03:24:30,938 --> 03:24:31,905 DR. WARNER MENTIONED AND WE 4231 03:24:31,905 --> 03:24:35,375 THINK THEY HAVE A ROLE. 4232 03:24:35,375 --> 03:24:38,812 AND I'M ALSO INTERESTED IN JAK 4233 03:24:38,812 --> 03:24:45,319 INHIBITORS AND THE FIBROBLASTS 4234 03:24:45,319 --> 03:24:47,988 ARE DOWN REGULATED TRANSCRIPTS 4235 03:24:47,988 --> 03:24:51,024 RELATED TO RP SIGNALLING. 4236 03:24:51,024 --> 03:24:55,295 AND FINALLY IN SYSTEMIC 4237 03:24:55,295 --> 03:24:57,965 DISEASES, HERE WE SEE IN OUR 4238 03:24:57,965 --> 03:24:59,900 SJOGREN'S FIBROBLASTS WE HAVE 4239 03:24:59,900 --> 03:25:04,504 INCREASED TRANSCRIPTS RELATED TO 4240 03:25:04,504 --> 03:25:09,543 THE COMPLIMENT SYSTEM. 4241 03:25:09,543 --> 03:25:11,111 WHAT'S NICE ABOUT SINGLE CELL 4242 03:25:11,111 --> 03:25:14,915 RNA SEQ DATA SET IS DISENTANGLE 4243 03:25:14,915 --> 03:25:19,253 THE FIBROBLAST SUB SETS. 4244 03:25:19,253 --> 03:25:23,890 WORKING WITH A STATISTICIAN AT 4245 03:25:23,890 --> 03:25:25,759 MICHIGAN WE STARTED 4246 03:25:25,759 --> 03:25:27,394 UNDERSTANDING WHAT THE SUB TYPE 4247 03:25:27,394 --> 03:25:30,530 ARE AND I WANT TO FOCUS ON THE 4248 03:25:30,530 --> 03:25:31,765 SUBSET OF FIBROBLASTS. 4249 03:25:31,765 --> 03:25:33,467 I THINK IT'S A NICE STORY TO 4250 03:25:33,467 --> 03:25:34,601 TELL BUT WE HAVE SO MANY TO TELL 4251 03:25:34,601 --> 03:25:39,706 FROM THE DATA SET. 4252 03:25:39,706 --> 03:25:43,076 WHAT IS DIFFERENT ABOUT THE 4253 03:25:43,076 --> 03:25:43,877 FIBROBLASTS? 4254 03:25:43,877 --> 03:25:45,746 SOMETHING SIMILAR HAS BEEN 4255 03:25:45,746 --> 03:25:46,847 DESCRIBED IN THE LITERATURE 4256 03:25:46,847 --> 03:25:47,147 RECENTLY. 4257 03:25:47,147 --> 03:25:49,616 THEY'VE BEEN LABELLED SOMETHING 4258 03:25:49,616 --> 03:25:53,553 CALLED IMMUNOFIBROBLASTS AT THE 4259 03:25:53,553 --> 03:25:58,492 MOST IMMUNE ACTIVE AND WHEN WE 4260 03:25:58,492 --> 03:26:02,696 FOCUS ON THE VOLCANO PLOT WE SEE 4261 03:26:02,696 --> 03:26:04,431 STRONGER INTERFERON RELATED 4262 03:26:04,431 --> 03:26:05,766 TRANSCRIPTS COMPARED TO THE 4263 03:26:05,766 --> 03:26:06,767 OTHER SUBSETS. 4264 03:26:06,767 --> 03:26:08,702 AND THERE ARE OTHER WAYS TO LOOK 4265 03:26:08,702 --> 03:26:11,038 RAT THAT TOO. 4266 03:26:11,038 --> 03:26:14,074 HERE ARE THE UPSTREAM 4267 03:26:14,074 --> 03:26:14,808 TRANSCRIPTIONAL REGULATORS AND 4268 03:26:14,808 --> 03:26:18,345 WE HAVE DIFFERENT CELL TYPE OF 4269 03:26:18,345 --> 03:26:20,781 INTEREST AND HERE WE CAN SEE 4270 03:26:20,781 --> 03:26:24,484 AGAIN THE FMO SUBTYPE ENRICHED 4271 03:26:24,484 --> 03:26:26,520 IN TRANSCRIPTION FACTORS RELATED 4272 03:26:26,520 --> 03:26:31,425 TO INTERFERONS INCLUDING IRF1 4273 03:26:31,425 --> 03:26:36,730 AND 7 AND 3 AND THE LIST GOES ON 4274 03:26:36,730 --> 03:26:38,398 BUT I DIDN'T WANT TO GO THROUGH 4275 03:26:38,398 --> 03:26:39,700 TOO MANY OF THAT. 4276 03:26:39,700 --> 03:26:45,038 AND THE OTHER THING WE CAN DO IS 4277 03:26:45,038 --> 03:26:47,307 LOOK AT THE TRANSCRIPTION FACTOR 4278 03:26:47,307 --> 03:26:52,846 NOT ONLY BY DISEASE STATE BUT BY 4279 03:26:52,846 --> 03:26:55,882 CELL TYPE. 4280 03:26:55,882 --> 03:27:01,755 HERE PITCHNK IS OUR CONTROL ANDU 4281 03:27:01,755 --> 03:27:06,460 CAN ONLY SEE THE GREEN BECAUSE 4282 03:27:06,460 --> 03:27:08,195 THIS TRANSCRIPTION FACTOR STAT 1 4283 03:27:08,195 --> 03:27:11,898 WIN THE INTERFERON SIGNATURE 4284 03:27:11,898 --> 03:27:17,304 WHAT YOU SEE CLEARLY IS FMO2 IS 4285 03:27:17,304 --> 03:27:19,072 THE ONLY SUBTYPE WITH 4286 03:27:19,072 --> 03:27:21,575 TRANSCRIPTION FACTOR EXPRESSION 4287 03:27:21,575 --> 03:27:24,244 AND NOT ONLY THAT BUT DISEASE 4288 03:27:24,244 --> 03:27:25,912 SPECIFIC IN OUR SJOGREN'S 4289 03:27:25,912 --> 03:27:26,346 PATIENTS. 4290 03:27:26,346 --> 03:27:28,382 I THINK THE PLOT NICELY 4291 03:27:28,382 --> 03:27:31,351 DEMONSTRATES WHEN WE'RE LOOKING 4292 03:27:31,351 --> 03:27:34,955 AT OUR FIBROBLAST SUBSETS WE SEE 4293 03:27:34,955 --> 03:27:37,023 NOT ONLY DISEASE STATE SPECIFIC 4294 03:27:37,023 --> 03:27:38,358 DIFFERENCES WHICH WE'D EXPECT 4295 03:27:38,358 --> 03:27:40,160 BUT CAN SEE CELL TYPE SPECIFIC 4296 03:27:40,160 --> 03:27:50,170 DIFFERENCES. 4297 03:27:50,170 --> 03:27:52,038 TO THE OTHER WAY IS TO LOOK AT 4298 03:27:52,038 --> 03:27:53,640 THE CELL-CELL COMMUNICATION AND 4299 03:27:53,640 --> 03:28:03,884 WHAT FIBROBLASTS AND FOCUS ON 4300 03:28:03,884 --> 03:28:06,987 THE UNIQUE INTERACTIONS WE SEE. 4301 03:28:06,987 --> 03:28:09,523 IN THIS IT'S FLIPPED, HIGHER 4302 03:28:09,523 --> 03:28:13,360 INTERACTION IS BLUE AND LOWER 4303 03:28:13,360 --> 03:28:14,127 INTERACTION IS RED. 4304 03:28:14,127 --> 03:28:19,900 AND THESE ARE INTERACTIONS 4305 03:28:19,900 --> 03:28:22,803 UNIQUE TO SJOGREN'S FIBROBLASTS 4306 03:28:22,803 --> 03:28:25,772 AND IF YOU LOOK AT THE TOP ROW 4307 03:28:25,772 --> 03:28:29,976 THOSE ARE THE FMO 2 FIBROBLASTS 4308 03:28:29,976 --> 03:28:34,848 AND THE OTHERS IN THE COLUMN 4309 03:28:34,848 --> 03:28:38,985 FIVE DOWN THERE'S SIMILARITIES 4310 03:28:38,985 --> 03:28:40,353 BETWEEN THE FIBROBLASTS SUB SETS 4311 03:28:40,353 --> 03:28:46,226 AND THE FMO2 FIBROBLASTS HAVE 4312 03:28:46,226 --> 03:28:47,394 HIGHER COMMUNICATION WITH THE 4313 03:28:47,394 --> 03:28:51,064 NEGATIVE CELLS WHICH ARE 4314 03:28:51,064 --> 03:28:57,070 PERIPHERALLY GENERATED CELLS 4315 03:28:57,070 --> 03:29:00,540 WITH A DIFFERENT PHENOTYPE AND 4316 03:29:00,540 --> 03:29:03,143 EFFICACY IN IMMUNOREGULATION. 4317 03:29:03,143 --> 03:29:06,012 I SAID OKAY, THE GOAL IS TO 4318 03:29:06,012 --> 03:29:08,215 BUILD A STRONG FOUNDATIONAL DATA 4319 03:29:08,215 --> 03:29:11,885 DEFINING THE PATHOGENESIS OF THE 4320 03:29:11,885 --> 03:29:13,787 FEMALE PREDOMINANT DISEASES. 4321 03:29:13,787 --> 03:29:14,921 AND TO FOSTER FUTURE WOMEN 4322 03:29:14,921 --> 03:29:18,458 HEALTH RESEARCH TO TRY TO REDUCE 4323 03:29:18,458 --> 03:29:19,392 THAT GAP PRESENT. 4324 03:29:19,392 --> 03:29:23,897 AND ANOTHER GOAL IS TO SUPPORT 4325 03:29:23,897 --> 03:29:24,998 BUILDING STRONG TEAMS AND 4326 03:29:24,998 --> 03:29:27,234 PROMOTE SUSTAINABILITY OF FUTURE 4327 03:29:27,234 --> 03:29:34,574 PROJECTS. 4328 03:29:34,574 --> 03:29:36,409 WITH THE FIBROBLASTS WORK WE'VE 4329 03:29:36,409 --> 03:29:39,045 DONE IS TO CORRELATING THEM TO 4330 03:29:39,045 --> 03:29:45,051 CLINICAL SYSTEMS AND PHENOTYPES 4331 03:29:45,051 --> 03:29:47,888 AND TRANSLATE TO OTHER DISEASES 4332 03:29:47,888 --> 03:29:52,492 AND TISSUES AND LUPUS AND 4333 03:29:52,492 --> 03:29:53,360 RHEUMATOID ARTHRITIS AND LINK IT 4334 03:29:53,360 --> 03:29:59,733 TO GWAS TO OUR UPCOMING E 4335 03:29:59,733 --> 03:30:02,302 EPIGENOMIC DATA TO IDENTIFY RISK 4336 03:30:02,302 --> 03:30:03,904 VARIANTS AND WITH THE LARGE DATA 4337 03:30:03,904 --> 03:30:08,642 SETS WHAT ABOUT OTHER STROMAL 4338 03:30:08,642 --> 03:30:09,042 CELLS? 4339 03:30:09,042 --> 03:30:12,712 THOSE CELLS ARE INTERESTING AND 4340 03:30:12,712 --> 03:30:14,281 I'D LOVE AN OPPORTUNITY TO 4341 03:30:14,281 --> 03:30:14,514 EXPLORE. 4342 03:30:14,514 --> 03:30:17,884 THESE ARE THE ACKNOWLEDGE MANIES 4343 03:30:17,884 --> 03:30:18,919 FOR THE AMP AIM LSP AND THANK 4344 03:30:18,919 --> 03:30:19,619 YOU TO EVERYONE FOR YOUR TIME 4345 03:30:19,619 --> 03:30:29,863 AND ATTENTION. 4346 03:30:33,900 --> 03:30:35,602 >> WONDERFUL. 4347 03:30:35,602 --> 03:30:38,071 THIS MINI SYMPOSIUM PROVIDED A 4348 03:30:38,071 --> 03:30:39,039 WONDERFUL EXAMPLE OF TEAM 4349 03:30:39,039 --> 03:30:39,906 SCIENCE BRIDGING TOGETHER 4350 03:30:39,906 --> 03:30:42,809 CLINICAL OUTCOMES, DATA, 4351 03:30:42,809 --> 03:30:44,911 EXPLORING DATA RE-USE AND THE 4352 03:30:44,911 --> 03:30:47,314 IMPORTANCE OF GETTING THE NEXT 4353 03:30:47,314 --> 03:30:47,881 GENERATION INVOLVED. 4354 03:30:47,881 --> 03:30:50,150 WE HAVE PERHAPS TIME FOR ONE 4355 03:30:50,150 --> 03:30:51,685 QUESTION AND THEN WE'LL MOVE TO 4356 03:30:51,685 --> 03:30:52,419 THE INITIATIVES. 4357 03:30:52,419 --> 03:30:55,889 THANKS TO ALL OF YOU FROM STAMP. 4358 03:30:55,889 --> 03:31:04,598 QUESTIONS FOR THE GROUP? 4359 03:31:04,598 --> 03:31:04,931 >> THANK YOU. 4360 03:31:04,931 --> 03:31:07,434 THAT WAS FASCINATING. 4361 03:31:07,434 --> 03:31:12,205 I HAVE A QUESTION FOR SARA. 4362 03:31:12,205 --> 03:31:17,377 THIL IS PAUL KREBSBACH FROM U 4363 03:31:17,377 --> 03:31:17,577 UCLA. 4364 03:31:17,577 --> 03:31:21,047 YOU SAID YOU LAD STORIES TO TELL 4365 03:31:21,047 --> 03:31:23,550 AND WITH THE TRANSCRIPTIONAL 4366 03:31:23,550 --> 03:31:27,053 RECTORS WHICH STORIES WILL YOU 4367 03:31:27,053 --> 03:31:30,790 HUNT DOWN FIRST AND DECIDE? 4368 03:31:30,790 --> 03:31:31,491 THERE'S SO MANY. 4369 03:31:31,491 --> 03:31:33,059 MAYBE YOUR LAB CAN HANDLE ALL OF 4370 03:31:33,059 --> 03:31:36,796 THEM BUT RIGHT NOW PROBABLY NOT. 4371 03:31:36,796 --> 03:31:41,201 >> JENNIFER KING IS AT UCLA AND 4372 03:31:41,201 --> 03:31:43,103 HAS A GREAT SJOGREN'S CLINIC AND 4373 03:31:43,103 --> 03:31:45,639 WE MEET REGULARLY. 4374 03:31:45,639 --> 03:31:46,172 I'M INTO TELLING SMALLER 4375 03:31:46,172 --> 03:31:56,316 STORIES. 4376 03:32:03,356 --> 03:32:09,195 WARE GOING TO FOCUS ON THE 4377 03:32:09,195 --> 03:32:14,134 FIBROBLASTS AND WE'VE GOT 4378 03:32:14,134 --> 03:32:17,437 NEGATIVE SUBJECTS AND WE 4379 03:32:17,437 --> 03:32:18,705 IDENTIFIED NEW TRANSCRIPTION 4380 03:32:18,705 --> 03:32:20,240 FACTORS AND HAVE AN IN VITRO 4381 03:32:20,240 --> 03:32:20,607 MODEL SYSTEM. 4382 03:32:20,607 --> 03:32:23,576 WE'RE WORKING ON A TWO-DAY 4383 03:32:23,576 --> 03:32:27,914 CULTURE BUT HAVE A 3-D CULTURE 4384 03:32:27,914 --> 03:32:31,051 SYSTEM AND KNOCKOUT 4385 03:32:31,051 --> 03:32:33,053 TRANSCRIPTION FACTORS AND SEE 4386 03:32:33,053 --> 03:32:35,889 HOW IT AFFECTS FIBROBLASTS' 4387 03:32:35,889 --> 03:32:39,059 BEHAVIOR IN THAT SETTING. 4388 03:32:39,059 --> 03:32:43,129 >> THANK YOU. 4389 03:32:43,129 --> 03:32:43,530 >> YES, THANK YOU. 4390 03:32:43,530 --> 03:32:44,164 I'LL LOOK FORWARD TO WATCHING 4391 03:32:44,164 --> 03:32:47,834 THIS GROW. 4392 03:32:47,834 --> 03:32:48,368 ALL RIGHT. 4393 03:32:48,368 --> 03:32:50,370 SO MOVING ON TO THE NEXT SESSION 4394 03:32:50,370 --> 03:32:55,108 WE'LL MOVE ON TO OUR CONCEPT 4395 03:32:55,108 --> 03:32:55,408 CLEARANCES. 4396 03:32:55,408 --> 03:32:56,609 WE ARE REQUIRED TO DOCUMENT THE 4397 03:32:56,609 --> 03:32:58,111 CLEARANCE OF CONCEPTS BY 4398 03:32:58,111 --> 03:32:59,345 PRESENTING THE PURPOSE, SCOPE 4399 03:32:59,345 --> 03:33:03,850 AND OBJECTIVES IN A PUBLIC FORUM 4400 03:33:03,850 --> 03:33:04,617 SUCH AS COUNCIL. 4401 03:33:04,617 --> 03:33:05,452 AND GETTING COUNCIL MEMBERS AND 4402 03:33:05,452 --> 03:33:07,921 THE PUBLIC AN OPPORTUNITY TO 4403 03:33:07,921 --> 03:33:11,591 COMMENT ON THE PROPOSED 4404 03:33:11,591 --> 03:33:11,891 CONCEPTS. 4405 03:33:11,891 --> 03:33:16,429 FOLLOWING THE PRESENTATION BY 4406 03:33:16,429 --> 03:33:18,198 NIDCR COUNCIL MEMBERS WILL LEAD 4407 03:33:18,198 --> 03:33:19,065 THE DISCUSSION FOLLOWED BY VOTE 4408 03:33:19,065 --> 03:33:22,535 FOR APPROVAL AS THE BASIS OF 4409 03:33:22,535 --> 03:33:23,870 DEVELOPING A FUTURE FUNDING 4410 03:33:23,870 --> 03:33:27,874 OPPORTUNITY SUCH AS REQUEST FOR 4411 03:33:27,874 --> 03:33:31,878 APPLICATIONS OR OTHER NOSIS OR 4412 03:33:31,878 --> 03:33:35,815 PARs NIH ISSUES. 4413 03:33:35,815 --> 03:33:37,083 WE'LL BEGIN WITH DR. DENA 4414 03:33:37,083 --> 03:33:39,052 FISCHER TO PRESENT THE FIRST 4415 03:33:39,052 --> 03:33:43,423 CONCEPT. 4416 03:33:43,423 --> 03:33:45,058 >> THANK YOU. 4417 03:33:45,058 --> 03:33:46,993 GOOD AFTERNOON, EVERYONE. 4418 03:33:46,993 --> 03:33:47,894 CAN YOU HEAR ME OKAY? 4419 03:33:47,894 --> 03:33:48,128 >> YES. 4420 03:33:48,128 --> 03:33:51,731 >> WONDERFUL. 4421 03:33:51,731 --> 03:33:53,633 THANK YOU FOR YOUR CONTINUED 4422 03:33:53,633 --> 03:33:55,869 ATTENTION DURING TODAY'S COUNCIL 4423 03:33:55,869 --> 03:33:56,202 MEETING. 4424 03:33:56,202 --> 03:33:59,172 I'M HERE SEEKING COUNCIL'S 4425 03:33:59,172 --> 03:34:01,307 CONCURRENCE FOR THIS CONCEPT 4426 03:34:01,307 --> 03:34:03,042 TITLED DENTAL PRIMARY CARE 4427 03:34:03,042 --> 03:34:04,410 PRACTICE-BASED RESEARCH NETWORK 4428 03:34:04,410 --> 03:34:07,480 TO SUPPORT RESEARCH IN CLINICAL 4429 03:34:07,480 --> 03:34:07,747 PRACTICES. 4430 03:34:07,747 --> 03:34:12,619 I'LL TAKE THE NEXT SLIDE. 4431 03:34:12,619 --> 03:34:18,758 SO THIS GOAL IS TO TRANSFORM AND 4432 03:34:18,758 --> 03:34:21,060 ADVANCE NIDCR SUPPORT OF 4433 03:34:21,060 --> 03:34:21,728 PRACTICE-BASED RESEARCH BY 4434 03:34:21,728 --> 03:34:25,198 ENDORSING A DENTAL PRIMARY CARE 4435 03:34:25,198 --> 03:34:27,433 BASED RESEARCH NETWORK OR PBRN 4436 03:34:27,433 --> 03:34:30,136 BUILDING ON THE KNOWLEDGE GAINED 4437 03:34:30,136 --> 03:34:31,905 AND LESSONS LEARNED FROM THE 4438 03:34:31,905 --> 03:34:35,308 PREVIOUS AND CURRENTLY FUNDED 4439 03:34:35,308 --> 03:34:37,710 NIDCR SUPPORTED PDRNs. 4440 03:34:37,710 --> 03:34:40,413 THE GOAL WILL BE ACCOMPLISHED BY 4441 03:34:40,413 --> 03:34:43,416 PROMOTING AN EFFICIENT AND AGILE 4442 03:34:43,416 --> 03:34:47,053 NETWORK FOCUSSED ON INTEGRATING 4443 03:34:47,053 --> 03:34:47,787 ORAL HEALTH CARE INTO WHOLE 4444 03:34:47,787 --> 03:34:51,891 PATIENT CARE OR OVERALL HEALTH 4445 03:34:51,891 --> 03:34:55,228 OR INFORMATION ON IMPORTANT ORAL 4446 03:34:55,228 --> 03:34:57,130 HEALTH PRACTICE IN PRACTICE 4447 03:34:57,130 --> 03:35:01,100 SETTINGS AND LOCATIONS. 4448 03:35:01,100 --> 03:35:04,671 SO THIS IS A GREAT TIME FOR ME 4449 03:35:04,671 --> 03:35:06,573 TO OFFER BACKGROUND ABOUT NIDCR 4450 03:35:06,573 --> 03:35:08,308 SUPPORT OF THE DENTAL 4451 03:35:08,308 --> 03:35:10,543 PRACTICE-BASED RESEARCH NETWORKS 4452 03:35:10,543 --> 03:35:11,878 AND YOU HEARD ABOUT THIS 4453 03:35:11,878 --> 03:35:15,048 THROUGHOUT THE DAY PARTICULARLY 4454 03:35:15,048 --> 03:35:19,886 FROM DR. WEBB-CYRIAQUE. 4455 03:35:19,886 --> 03:35:22,388 THE FIRST CYCLE OF FUNDING WAS 4456 03:35:22,388 --> 03:35:24,390 2005 TO 2012 WHEN NIDCR 4457 03:35:24,390 --> 03:35:31,164 SUPPORTED THREE REGIONAL DENTAL 4458 03:35:31,164 --> 03:35:35,869 PBRNs IN THREE DISTINCT AREAS IN 4459 03:35:35,869 --> 03:35:37,770 THE UNITED STATES. 4460 03:35:37,770 --> 03:35:42,809 THEY CONDUCTED RESEARCH STUDIES 4461 03:35:42,809 --> 03:35:44,677 AND ALSO THESE THREE SEPARATE 4462 03:35:44,677 --> 03:35:46,279 PBRNs ON STUDIES ACROSS THE 4463 03:35:46,279 --> 03:35:49,916 THREE REGIONAL NETWORKS. 4464 03:35:49,916 --> 03:35:53,386 THEN THE SECOND CYCLE TOOK PLACE 4465 03:35:53,386 --> 03:35:55,922 FROM 2012 TO 2019 AND DURING 4466 03:35:55,922 --> 03:36:01,160 THIS CYCLE OF FUNDING NIDCR 4467 03:36:01,160 --> 03:36:03,496 SUPPORTED ONE NATIONAL DENTAL 4468 03:36:03,496 --> 03:36:09,802 PBRN AND IT WAS CONFIGURED WITH 4469 03:36:09,802 --> 03:36:14,140 SIX REGIONAL HUBS OR INSTITUTIVE 4470 03:36:14,140 --> 03:36:15,875 SITES BY ONE AWARD. 4471 03:36:15,875 --> 03:36:18,978 IT ALSO SUPPORTED THE PBRN 4472 03:36:18,978 --> 03:36:19,979 RESEARCH STUDIES WITHIN THE 4473 03:36:19,979 --> 03:36:20,947 LARGER NETWORK. 4474 03:36:20,947 --> 03:36:27,053 OVER THE COURSE OF THE FUNDING 4475 03:36:27,053 --> 03:36:29,923 PERIOD THEY EXPANDED 4476 03:36:29,923 --> 03:36:30,757 PRACTITIONERS TO INVOLVE 4477 03:36:30,757 --> 03:36:31,891 PRACTITIONERS ACROSS THE UNITED 4478 03:36:31,891 --> 03:36:42,035 STATES. 4479 03:36:46,105 --> 03:36:51,311 IT BEGAN IN 2019 AND CONTINUE 4480 03:36:51,311 --> 03:36:52,211 THROUGH MAY 2026. 4481 03:36:52,211 --> 03:36:53,780 NIDCR IS SUPPORTING THE NETWORK 4482 03:36:53,780 --> 03:36:55,815 INFRASTRUCTURE THROUGH TWO 4483 03:36:55,815 --> 03:36:56,049 AWARDS. 4484 03:36:56,049 --> 03:37:00,486 ONE IS THE ADMINISTRATIVE AND 4485 03:37:00,486 --> 03:37:02,255 RESOURCE CENTER WHICH HAS SIX 4486 03:37:02,255 --> 03:37:05,224 REGIONAL NODE OR ADMINISTRATE IR 4487 03:37:05,224 --> 03:37:07,427 SITES AND ONE SPECIALTY 4488 03:37:07,427 --> 03:37:09,162 DENTISTRY NODE. 4489 03:37:09,162 --> 03:37:11,130 AND THAT CENTER IS PRIMARILY 4490 03:37:11,130 --> 03:37:15,034 RESPONSIBLE FOR RECRUITING AND 4491 03:37:15,034 --> 03:37:15,768 RETAINING PRACTITIONERS ACROSS 4492 03:37:15,768 --> 03:37:17,403 THE UNITED STATES ALL STATES IN 4493 03:37:17,403 --> 03:37:19,105 THE UNITED STATES AND THESE 4494 03:37:19,105 --> 03:37:23,776 PRACTITIONERS ARE PARTICIPATING 4495 03:37:23,776 --> 03:37:25,378 IN RESEARCH STUDIES BY 4496 03:37:25,378 --> 03:37:26,045 COLLECTING RESEARCH DATA ON 4497 03:37:26,045 --> 03:37:29,749 THEIR CONSENTING PATIENTS. 4498 03:37:29,749 --> 03:37:32,118 SO THEN THERE'S A NETWORK 4499 03:37:32,118 --> 03:37:33,820 COORDINATING CENTER WHICH 4500 03:37:33,820 --> 03:37:34,988 MAINTAINS A PRACTITIONER MEMBER 4501 03:37:34,988 --> 03:37:45,064 DATABASE. 4502 03:37:45,064 --> 03:37:46,733 AND STATISTICAL SUPPORT FOR 4503 03:37:46,733 --> 03:37:47,834 STUDIES CONDUCTED WITHIN THE 4504 03:37:48,735 --> 03:37:49,769 PBRN. 4505 03:37:49,769 --> 03:37:51,137 IN THE CURRENT STRUCTURE THE 4506 03:37:51,137 --> 03:37:56,376 RESEARCH STUDIES ARE FUNDED 4507 03:37:56,376 --> 03:38:01,214 THROUGH GRANT MECHANISMS. 4508 03:38:01,214 --> 03:38:03,883 THERE ARE OVER 8400 PRACTITIONER 4509 03:38:03,883 --> 03:38:07,887 MEMBERS OF AND A MEMBER PLAY NOT 4510 03:38:07,887 --> 03:38:10,189 NECESSARILY BE A PARTICIPATING 4511 03:38:10,189 --> 03:38:11,891 IN RESEARCH STUDIES. 4512 03:38:11,891 --> 03:38:18,464 8400 MEMBERS AND CLOSE TO 5700 4513 03:38:18,464 --> 03:38:22,301 OF THOSE HAVE PARTICIPATED IN 4514 03:38:22,301 --> 03:38:22,702 RESEARCH STUDIES. 4515 03:38:22,702 --> 03:38:25,705 COMBINED THEY HAVE ENROLLED OVER 4516 03:38:25,705 --> 03:38:30,243 75,000 PATIENTS AND CONTRIBUTED 4517 03:38:30,243 --> 03:38:31,878 DATA FROM OVER 790,000 PATIENT 4518 03:38:31,878 --> 03:38:39,685 HEALTH RECORDS. 4519 03:38:39,685 --> 03:38:43,890 FOR EACH OF THE THREE CYCLES FOR 4520 03:38:43,890 --> 03:38:45,591 STUDIES CONDUCTED IN THE 4521 03:38:45,591 --> 03:38:50,663 NATIONAL DENTAL PBRN HAVE BEEN 4522 03:38:50,663 --> 03:38:51,931 THOSE GENERATED FROM 4523 03:38:51,931 --> 03:38:53,833 PRACTITIONERS AND RESEARCHERS 4524 03:38:53,833 --> 03:38:58,905 PROPOSING TO CONDUCT RESEARCH 4525 03:38:58,905 --> 03:39:08,247 WITHIN THE INFRASTRUCTURE 4526 03:39:08,247 --> 03:39:09,649 OVERALL WE CAN SAY THE PRACTICE 4527 03:39:09,649 --> 03:39:12,785 BASED NETWORK IS A UNIQUE VENUE 4528 03:39:12,785 --> 03:39:14,720 IN WHICH TO CONDUCT RESEARCH IN 4529 03:39:14,720 --> 03:39:24,063 WHICH DENTAL PRACTITIONERS AND 4530 03:39:24,063 --> 03:39:26,966 PARTICIPANTS ARE ABLE TO ENROLL 4531 03:39:26,966 --> 03:39:27,233 PATIENTS. 4532 03:39:27,233 --> 03:39:31,771 EACH PRACTITIONER MAY ENROLL A 4533 03:39:31,771 --> 03:39:32,905 RELATIVELY SMALL NUMBER OF 4534 03:39:32,905 --> 03:39:35,341 PATIENT PARTICIPANTS BUT TAKEN 4535 03:39:35,341 --> 03:39:36,542 WITH A LARGE NUMBER 4536 03:39:36,542 --> 03:39:38,344 PARTICIPATING THE STUDY CAN 4537 03:39:38,344 --> 03:39:38,811 ENROLL LARGE NUMBERS 4538 03:39:38,811 --> 03:39:45,051 EFFICIENTLY. 4539 03:39:45,051 --> 03:39:48,821 TO ADDRESS PERCEIVED GAPS IN THE 4540 03:39:48,821 --> 03:39:53,159 PBRNs THE FUTURE DENTAL PRIMARY 4541 03:39:53,159 --> 03:39:54,994 CARE WILL EMPHASIZE TOPICS THAT 4542 03:39:54,994 --> 03:39:56,963 PROMOTE THE INTEGRATION OF ORAL 4543 03:39:56,963 --> 03:39:59,866 HEALTH CARE INTO MEDICAL CARE OR 4544 03:39:59,866 --> 03:40:06,439 WHOLE PERSON HEALTH. 4545 03:40:06,439 --> 03:40:09,041 THE FUTURE NETWORK WILL FORMAL 4546 03:40:09,041 --> 03:40:13,913 I'D CLINICAL SKILL TRAINING AND 4547 03:40:13,913 --> 03:40:14,814 MENTORING AND PROVIDE 4548 03:40:14,814 --> 03:40:15,781 OPPORTUNITIES FOR ENHANCE 789 4549 03:40:15,781 --> 03:40:19,252 FOR THOSE CONDUCTING AND/OR 4550 03:40:19,252 --> 03:40:20,620 PARTICIPATING IN RESEARCH 4551 03:40:20,620 --> 03:40:20,853 STUDIES. 4552 03:40:20,853 --> 03:40:23,689 AND THE FUTURE NETWORK WILL ALSO 4553 03:40:23,689 --> 03:40:25,158 EMPHASIZE RECRUITING 4554 03:40:25,158 --> 03:40:26,526 PRACTITIONERS WHO PRACTICE IN 4555 03:40:26,526 --> 03:40:28,561 RURAL AREAS AND/OR PRIMARILY 4556 03:40:28,561 --> 03:40:30,429 CARE FOR UNDER SERVED 4557 03:40:30,429 --> 03:40:39,906 POPULATIONS. 4558 03:40:39,906 --> 03:40:43,876 TO GIVE AN EXAMPLE OF TOPICS OF 4559 03:40:43,876 --> 03:40:45,378 INTEREST RESEARCH FOCUS ON 4560 03:40:45,378 --> 03:40:49,448 EVIDENCE TO SUPPORT SCREENING OF 4561 03:40:49,448 --> 03:40:51,284 MEDICAL CONDITIONS AND RISK 4562 03:40:51,284 --> 03:40:52,785 BEHAVIORS BY ORAL HEALTH 4563 03:40:52,785 --> 03:40:53,753 PROFESSIONALS AND APPROPRIATE 4564 03:40:53,753 --> 03:40:55,221 FOLLOW-UP FOR CARE. 4565 03:40:55,221 --> 03:40:56,022 SOME EXAMPLES MAY INCLUDE 4566 03:40:56,022 --> 03:40:58,257 COMPARING THE EFFECTIVENESS OF 4567 03:40:58,257 --> 03:40:59,892 DIFFERENT SCREENING APPROACHES 4568 03:40:59,892 --> 03:41:07,767 IN DENTAL CARE SETTINGS, 4569 03:41:07,767 --> 03:41:08,401 EVALUATED EFFORTS AMONG HEALTH 4570 03:41:08,401 --> 03:41:11,404 CARE PROFESSIONALS AND ENHANCE 4571 03:41:11,404 --> 03:41:14,473 SCREENING AND REFERRAL USING 4572 03:41:14,473 --> 03:41:16,609 VARIOUS FORM OF TECHNOLOGY AND 4573 03:41:16,609 --> 03:41:22,348 NEW INSTRUMENT ALGORITHMS OR 4574 03:41:22,348 --> 03:41:23,849 TECHNOLOGIES AND RESEARCH FOR 4575 03:41:23,849 --> 03:41:27,086 RATES OF APPROVAL FOLLOWING 4576 03:41:27,086 --> 03:41:27,353 SCREENING. 4577 03:41:27,353 --> 03:41:29,989 OTHER TOPICS ARE ORAL DISEASE 4578 03:41:29,989 --> 03:41:31,724 PREVENTION OR TREATMENT OUTCOME 4579 03:41:31,724 --> 03:41:35,895 THROUGH LONGITUDINAL STUDIES AND 4580 03:41:35,895 --> 03:41:36,362 INTEREST OF SPECIALTY 4581 03:41:36,362 --> 03:41:46,606 ORGANIZATIONS. 4582 03:41:57,149 --> 03:42:00,653 NEXT WE'LL MOVE ON TO HAVING OUR 4583 03:42:00,653 --> 03:42:02,221 FIRST COUNCIL REVIEWER PROVIDE 4584 03:42:02,221 --> 03:42:03,489 FEEDBACK AND THAT WOULD BE 4585 03:42:03,489 --> 03:42:13,699 DR. PIETRO. 4586 03:42:15,735 --> 03:42:19,238 >> THANK YOU, DR. FISCHER. 4587 03:42:19,238 --> 03:42:22,475 I'M SUPPORTIVE OF THE CONCEPT 4588 03:42:22,475 --> 03:42:23,209 AND MANY REASONS. 4589 03:42:23,209 --> 03:42:26,846 AS DR. FISCHER MENTIONED, NIDCR 4590 03:42:26,846 --> 03:42:30,816 HAS BEEN SUPPORTING THE PBRNs 4591 03:42:30,816 --> 03:42:34,954 SINCE 2005 AND HAVE BEEN VERY 4592 03:42:34,954 --> 03:42:36,856 SUCCESSFUL AND SOME INCLUDE LIKE 4593 03:42:36,856 --> 03:42:39,859 6,000 PRACTITIONERS ENROLLED 4594 03:42:39,859 --> 03:42:41,894 OVER 75,000 PATIENTS AND LOOKED 4595 03:42:41,894 --> 03:42:47,900 AT ALMOST 7 800,000 PATIENT 4596 03:42:47,900 --> 03:42:51,971 HEALTH RECORDS AND PRODUCED 225 4597 03:42:51,971 --> 03:42:54,206 PUBLICATIONS AND THERE'S 18 4598 03:42:54,206 --> 03:42:57,076 ADDITIONAL STUDIES ONGOING AND 4599 03:42:57,076 --> 03:42:59,512 EXPECTED TO BE COMPLETED IN THE 4600 03:42:59,512 --> 03:43:00,946 THIRD PHASE AND TRIALS AND 4601 03:43:00,946 --> 03:43:06,152 STUDIES AND STUDIES INVOLVING 4602 03:43:06,152 --> 03:43:07,920 COVID-19. 4603 03:43:07,920 --> 03:43:10,389 AND THOSE METRICS OF 4604 03:43:10,389 --> 03:43:11,891 PRODUCTIVITY AND THERE'S THE 4605 03:43:11,891 --> 03:43:15,661 IMPORTANCE OF PBRNs AND ENGAGE 4606 03:43:15,661 --> 03:43:16,729 RESEARCHERS AND THAT'S CRUCIAL 4607 03:43:16,729 --> 03:43:18,297 TO PROGRESS AND THEY ARE 4608 03:43:18,297 --> 03:43:21,067 FACILITATE THE TRANSLATION OF 4609 03:43:21,067 --> 03:43:24,103 RESEARCH FINDINGS INTO CLINICAL 4610 03:43:24,103 --> 03:43:24,603 PRACTICE. 4611 03:43:24,603 --> 03:43:35,081 WE KNOW DENTAL PBRNs CAN BE 4612 03:43:35,081 --> 03:43:36,582 PRODUCTIVE RESEARCH ENDEAVORS. 4613 03:43:36,582 --> 03:43:38,551 WE TO THE THEY CONTRIBUTE 4614 03:43:38,551 --> 03:43:40,686 SIGNIFICANTLY TO THE LANDSCAPE 4615 03:43:40,686 --> 03:43:41,554 OF PRIMARY CARE. 4616 03:43:41,554 --> 03:43:43,923 SO THAT ALONE WOULD BE ENOUGH TO 4617 03:43:43,923 --> 03:43:46,025 CONTINUE IT BUT THIS PARTICULAR 4618 03:43:46,025 --> 03:43:49,495 CONCEPT NOW HAS CHANGES THAT 4619 03:43:49,495 --> 03:43:52,531 MAKE IT EVEN MORE DESIRABLE AND 4620 03:43:52,531 --> 03:43:52,765 BETTER. 4621 03:43:52,765 --> 03:43:55,034 THE ADMINISTRATIVE STRUCTURE IS 4622 03:43:55,034 --> 03:43:57,436 GOING TO BE GENERALLY THE SAME 4623 03:43:57,436 --> 03:43:58,671 BECAUSE IT'S EFFECTIVE BUT THERE 4624 03:43:58,671 --> 03:44:00,272 ARE THREE SIGNIFICANT CHANGES 4625 03:44:00,272 --> 03:44:01,574 THAT HAVE BEEN INCORPORATED. 4626 03:44:01,574 --> 03:44:05,311 THE FIRST IS THE ADDITION OF THE 4627 03:44:05,311 --> 03:44:06,045 FORMAL CLINICAL RESEARCH SKILL 4628 03:44:06,045 --> 03:44:08,414 TRAINING AND THE MENTORING FOR 4629 03:44:08,414 --> 03:44:10,416 MEMBERS OF THE PBRN. 4630 03:44:10,416 --> 03:44:11,117 THAT'S VERY IMPORTANT AND IT 4631 03:44:11,117 --> 03:44:19,024 WILL BE VERY HELPFUL TO PROGRESS 4632 03:44:19,024 --> 03:44:22,361 OF THE PBRNs AND TOPICS OF 4633 03:44:22,361 --> 03:44:23,162 INTEGRATING ORAL HEALTH CARE TO 4634 03:44:23,162 --> 03:44:23,896 MEDICAL CARE. 4635 03:44:23,896 --> 03:44:27,099 IN MY OPINION THAT'S AN 4636 03:44:27,099 --> 03:44:28,300 OUTSTANDING DECISION AND ALIGNS 4637 03:44:28,300 --> 03:44:31,904 WITH WHAT WE HEARD ABOUT THE 4638 03:44:31,904 --> 03:44:33,105 RESEARCH PRIORITIES AND THE 4639 03:44:33,105 --> 03:44:35,908 FINAL CHANGE IS EXTREMELY 4640 03:44:35,908 --> 03:44:39,645 IMPORTANT ALSO THAT'S THE 4641 03:44:39,645 --> 03:44:41,781 EMPHASIS ON INCLUDING MORE 4642 03:44:41,781 --> 03:44:43,682 PRACTITIONERS AND THE UNDER 4643 03:44:43,682 --> 03:44:47,086 SERVED AND IN MY CURRENT PBRN MY 4644 03:44:47,086 --> 03:44:47,920 UNDERSTANDING IS THAT'S QUITE 4645 03:44:47,920 --> 03:44:49,388 SMALL AND THOSE THAT PLAY A ROLE 4646 03:44:49,388 --> 03:44:51,724 OR SERVING THE UNDER SERVED IS 4647 03:44:51,724 --> 03:44:54,894 ONLY ABOUT 5% AND GET THE LEVEL 4648 03:44:54,894 --> 03:44:56,228 TO 50%. 4649 03:44:56,228 --> 03:45:01,600 I THINK THIS IS AN OUTSTANDING 4650 03:45:01,600 --> 03:45:01,867 GOAL. 4651 03:45:01,867 --> 03:45:06,071 IT WILL ACCELERATE THE 4652 03:45:06,071 --> 03:45:08,607 SIGNIFICANCE OF THE RESEARCH 4653 03:45:08,607 --> 03:45:11,043 FINDINGS TO THOSE RURAL AND 4654 03:45:11,043 --> 03:45:12,978 UNDER SERVED POPULATIONS AND 4655 03:45:12,978 --> 03:45:16,682 THIS IDEA OF INCORPORATING MORE 4656 03:45:16,682 --> 03:45:19,585 ACTIVITY AMONG THE UNDER SERVED 4657 03:45:19,585 --> 03:45:23,889 AND RURAL POPULATIONS ALIGNS 4658 03:45:23,889 --> 03:45:30,062 WITH NIDCR PRIORITIES AND 4659 03:45:30,062 --> 03:45:31,297 CRITICAL NIH PRIORITIES. 4660 03:45:31,297 --> 03:45:35,901 SO OVER ALL I THINK THE PROPOSED 4661 03:45:35,901 --> 03:45:38,037 CONCEPT WILL IMPROVE ON 4662 03:45:38,037 --> 03:45:39,038 SOMETHING ALREADY SUCCESSFUL 4663 03:45:39,038 --> 03:45:40,606 WITH IMPROVED DISTRIBUTION OF 4664 03:45:40,606 --> 03:45:43,075 THE PRACTITIONERS TO THE RURAL 4665 03:45:43,075 --> 03:45:44,877 AND UNDER SERVED COMMUNITIES AND 4666 03:45:44,877 --> 03:45:46,846 THE FOCUS ON SCREENING MEDICAL 4667 03:45:46,846 --> 03:45:49,081 CONDITIONS OR ALIGNING WITH 4668 03:45:49,081 --> 03:45:54,220 MEDICAL CARE I THINK THE PBRNs 4669 03:45:54,220 --> 03:45:56,155 WILL BECOME MORE CRUCIAL TO 4670 03:45:56,155 --> 03:45:59,391 IMPROVING ORAL HEALTH AND FOSTER 4671 03:45:59,391 --> 03:46:01,160 THE INTERSECTION BETWEEN ORAL 4672 03:46:01,160 --> 03:46:02,094 AND SYSTEMIC HEALTH. 4673 03:46:02,094 --> 03:46:03,128 FOR ALL THOSE REASONS I'M VERY 4674 03:46:03,128 --> 03:46:09,034 SUPPORTIVE OF THIS. 4675 03:46:09,034 --> 03:46:11,303 >> THANK YOU. 4676 03:46:11,303 --> 03:46:15,140 WONDERFUL COMMENT AND THANKS 4677 03:46:15,140 --> 03:46:18,244 VERY MUCH FOR YOUR INPUT. 4678 03:46:18,244 --> 03:46:20,980 NOW WE CAN MOVE TO DR. DICKINSON 4679 03:46:20,980 --> 03:46:22,314 AND HEAR ABOUT ANY FEEDBACK 4680 03:46:22,314 --> 03:46:28,988 PERTAINING TO THIS CONCEPT. 4681 03:46:28,988 --> 03:46:31,757 I AGREE WITH EVERYTHING BRUTH 4682 03:46:31,757 --> 03:46:32,691 UP AS FAR AS WHY WE NEED TO 4683 03:46:32,691 --> 03:46:34,660 CONTINUE THE PROGRAM. 4684 03:46:34,660 --> 03:46:37,897 I KIND OF TOOK A NON-TRADITIONAL 4685 03:46:37,897 --> 03:46:39,665 LOOK AT THIS AND SO I WANTED TO 4686 03:46:39,665 --> 03:46:45,671 COMMENT ON A COUPLE THINGS. 4687 03:46:45,671 --> 03:46:46,872 THOSE IN THE CLINICAL PRACTICE 4688 03:46:46,872 --> 03:46:49,275 CONTINUE TO BE CHALLENGED BY THE 4689 03:46:49,275 --> 03:46:51,176 MULTIPLE CHOICES WE OFTEN HAVE 4690 03:46:51,176 --> 03:46:52,912 FACING US AS WE TEMPT TO PROVIDE 4691 03:46:52,912 --> 03:46:53,779 THE BEST POSSIBLE CARE TO OUR 4692 03:46:53,779 --> 03:46:57,516 PATIENTS. 4693 03:46:57,516 --> 03:47:00,219 FOR EXAMPLE SEVERAL YEARS AGO A 4694 03:47:00,219 --> 03:47:02,588 PATIENT WAS SENT TO DENTISTS TO 4695 03:47:02,588 --> 03:47:04,390 GET DIAGNOSIS AND TREATMENT PLAN 4696 03:47:04,390 --> 03:47:04,990 WITHOUT REGARDS TO COST AND 4697 03:47:04,990 --> 03:47:08,761 OTHER FACTORS. 4698 03:47:08,761 --> 03:47:12,197 SURPRISINGLY OR NOT THERE WAS A 4699 03:47:12,197 --> 03:47:17,469 WIDE VARIETY OF SUGGESTED 4700 03:47:17,469 --> 03:47:19,271 TREATMENT PLANS. 4701 03:47:19,271 --> 03:47:20,940 CERTAINLY THERE'S DIFFERENCES 4702 03:47:20,940 --> 03:47:23,509 WITH COST AND FACTORS ARE 4703 03:47:23,509 --> 03:47:23,909 INTRODUCED. 4704 03:47:23,909 --> 03:47:24,710 SO OFTEN DIFFERENT TREATMENT 4705 03:47:24,710 --> 03:47:26,312 PLANS ARE OFFERED TO THE 4706 03:47:26,312 --> 03:47:27,112 PATIENTS BASED ON THEIR 4707 03:47:27,112 --> 03:47:33,118 CIRCUMSTANCES. 4708 03:47:33,118 --> 03:47:34,853 HOWEVER OFTEN THE DECISION TO 4709 03:47:34,853 --> 03:47:39,124 TREAT A TOOTH OR NOT COMES IN 4710 03:47:39,124 --> 03:47:40,859 OFTEN AND IT'S IMPORTANT TO GAIN 4711 03:47:40,859 --> 03:47:42,294 EVIDENCE-BASED CARE ABOUT THE 4712 03:47:42,294 --> 03:47:44,496 FACTORS THAT CREATE THE DECISION 4713 03:47:44,496 --> 03:47:46,465 POINTS THAT ARE CRITICAL TO 4714 03:47:46,465 --> 03:47:50,436 MAKING SOUND DECISIONS ABOUT THE 4715 03:47:50,436 --> 03:47:51,070 CARE OF EACH INDIVIDUAL PATIENT. 4716 03:47:51,070 --> 03:47:52,738 IF THE GOAL IS TO TRANSLATE 4717 03:47:52,738 --> 03:47:55,341 RESEARCH FINDINGS INTO HELPING 4718 03:47:55,341 --> 03:47:57,109 THE PRACTITIONER MAKE THE 4719 03:47:57,109 --> 03:47:59,912 DECISIONS, THIS CONCEPT NEEDS TO 4720 03:47:59,912 --> 03:48:03,916 BE CONTINUED WITH THE BROADER 4721 03:48:03,916 --> 03:48:05,651 BASE NETWORK IT SUGGESTS. 4722 03:48:05,651 --> 03:48:08,187 THE BROADER-BASED APPROACH IS 4723 03:48:08,187 --> 03:48:11,457 ONE OF THE KEYS TO GAINING DATA 4724 03:48:11,457 --> 03:48:13,425 AND PROVIDING IMPORTANT CHANGES 4725 03:48:13,425 --> 03:48:15,961 IN CLINICAL TREATMENT CHOICES IN 4726 03:48:15,961 --> 03:48:18,998 A MORE SYSTEMIC MANNER, 4727 03:48:18,998 --> 03:48:20,366 BROADENING THE BASE OF INVOLVED 4728 03:48:20,366 --> 03:48:22,768 PRACTITIONERS AND RECRUITING 4729 03:48:22,768 --> 03:48:24,737 PRACTITIONERS IN RURAL AND UNDER 4730 03:48:24,737 --> 03:48:25,838 SERVED AREAS ARE OF BENEFIT TO 4731 03:48:25,838 --> 03:48:27,539 THE GOALS OF THE CONCEPT. 4732 03:48:27,539 --> 03:48:30,242 THE CHALLENGE OF FINDING 4733 03:48:30,242 --> 03:48:31,910 PRACTICES WHERE 50% OF THE 4734 03:48:31,910 --> 03:48:33,178 PATIENTS WHO RECEIVE BENEFITS 4735 03:48:33,178 --> 03:48:33,779 THROUGH MEDICAID MAY BE OF 4736 03:48:33,779 --> 03:48:40,452 CHALLENGE. 4737 03:48:40,452 --> 03:48:47,092 MOST PRACTICES ARE PEDIATRIC OR 4738 03:48:47,092 --> 03:48:48,360 POSSIBLY DENTAL SCHOOLS. 4739 03:48:48,360 --> 03:48:51,130 HOW WILL YOU DISSEMINATE AND SEE 4740 03:48:51,130 --> 03:48:54,299 IT'S IMPLEMENTED IN A DIFFERENT 4741 03:48:54,299 --> 03:48:58,470 METHOD USED CURRENTLY IN THE 4742 03:48:58,470 --> 03:48:59,838 PBRN NETWORK. 4743 03:48:59,838 --> 03:49:01,507 INCLUDING A WHOLE HEALTH 4744 03:49:01,507 --> 03:49:05,844 COMPONENT WOULD BE OF GREAT 4745 03:49:05,844 --> 03:49:07,179 BENEFIT TO THIS POPULATION. 4746 03:49:07,179 --> 03:49:11,617 MOST DENTAL PRACTITIONERS TAKE 4747 03:49:11,617 --> 03:49:13,719 BLOOD PRESSURE AND PULSE AND 4748 03:49:13,719 --> 03:49:14,586 TEMPERATURE. 4749 03:49:14,586 --> 03:49:17,623 THERE'S MORE THEY CAN DO 4750 03:49:17,623 --> 03:49:20,159 INCLUDING THE PULSE OXIMETER AND 4751 03:49:20,159 --> 03:49:26,265 BLOOD SUGAR OR A1C READING. 4752 03:49:26,265 --> 03:49:29,435 WE'RE CAPABLE IS OF DOING THIS 4753 03:49:29,435 --> 03:49:34,573 ON A REGULAR PARTICULARLY THOSE 4754 03:49:34,573 --> 03:49:36,308 WHO EXPERIENCE HEALTH YKT 4755 03:49:36,308 --> 03:49:38,711 INEQUITIES AND DON'T HAVE A PCP. 4756 03:49:38,711 --> 03:49:39,912 IT'S A BROAD BASED APPROACH WITH 4757 03:49:39,912 --> 03:49:45,150 SIGNIFICANT CHANGES TO THE PBRNs 4758 03:49:45,150 --> 03:49:46,251 WHICH EXIST. 4759 03:49:46,251 --> 03:49:47,252 I'M CONCERNED ABOUT THE WIDE 4760 03:49:47,252 --> 03:49:50,255 REACH ON MANY SUBJECTS ALL OF 4761 03:49:50,255 --> 03:49:51,590 WHICH HAVE COMPLEXITIES. 4762 03:49:51,590 --> 03:49:53,459 PERHAPS I'M FOCUSSING ON KEY 4763 03:49:53,459 --> 03:49:55,227 ISSUES THAT COULD BE BROADENED 4764 03:49:55,227 --> 03:49:57,396 IN THE FUTURE AND MIGHT BE OF 4765 03:49:57,396 --> 03:49:57,663 INTEREST. 4766 03:49:57,663 --> 03:49:59,264 I THINK ONE OF THE THINGS WE'RE 4767 03:49:59,264 --> 03:50:03,202 SEEING IN THE PROFESSION IS THE 4768 03:50:03,202 --> 03:50:06,305 USE OF A.I. 4769 03:50:06,305 --> 03:50:07,773 CURRENTLY THERE ARE FIVE 4770 03:50:07,773 --> 03:50:09,508 APPROVED A.I. SYSTEMS WHICH I 4771 03:50:09,508 --> 03:50:11,610 THINK WILL HAVE A GREAT IMPACT 4772 03:50:11,610 --> 03:50:15,247 ON THE PROFESSION OF DENTISTRY. 4773 03:50:15,247 --> 03:50:18,684 I SEE MORE EVIDENCE IN 4774 03:50:18,684 --> 03:50:19,418 EVIDENCE-BASED CARE GOING 4775 03:50:19,418 --> 03:50:19,818 FORWARD. 4776 03:50:19,818 --> 03:50:23,922 I THINK IT'S A GREAT CONCEPT AND 4777 03:50:23,922 --> 03:50:29,495 I CERTAINLY SUPPORT WHAT LOUISA 4778 03:50:29,495 --> 03:50:31,230 SAID AND ENCOURAGE YOU TO VOTE 4779 03:50:31,230 --> 03:50:32,731 POSITIVE FOR IT. 4780 03:50:32,731 --> 03:50:35,634 >> ARE THERE ANY OTHER COMMENTS 4781 03:50:35,634 --> 03:50:39,138 FROM COUNCIL MEMBERS BEFORE WE 4782 03:50:39,138 --> 03:50:46,879 MOVE TO VOTING? 4783 03:50:46,879 --> 03:50:49,848 >> THIS IS PAUL FROM UCLA. 4784 03:50:49,848 --> 03:50:54,686 MY INTENT IS NOT TO BE A STRONG 4785 03:50:54,686 --> 03:50:57,156 CONTRARIAN BUT RATHER TO SAY 4786 03:50:57,156 --> 03:50:58,457 AFTER ALMOST 20 YEARS AND A LOT 4787 03:50:58,457 --> 03:51:04,596 OF DOLLARS I'M WONDERING IF WHAT 4788 03:51:04,596 --> 03:51:05,798 KIND OF REAL ASSESSMENT NIDCR 4789 03:51:05,798 --> 03:51:10,736 HAS TAKEN TO LOOK AT THE SUCCESS 4790 03:51:10,736 --> 03:51:11,837 OF HOW THIS HAS GONE. 4791 03:51:11,837 --> 03:51:13,939 IT'S A LONG TIME. 4792 03:51:13,939 --> 03:51:16,542 THERE'S PLENTY OF TIME TO MAKE 4793 03:51:16,542 --> 03:51:19,411 THE RIGHT ASSESSMENTS. 4794 03:51:19,411 --> 03:51:20,345 YOU CAN COUNT HOW MANY PAPERS 4795 03:51:20,345 --> 03:51:23,215 PER DOLLAR OR YEAR. 4796 03:51:23,215 --> 03:51:24,483 HOW HAS IT -- WHAT'S THE IMPACT 4797 03:51:24,483 --> 03:51:34,726 OF IT SO FAR. 4798 03:51:35,694 --> 03:51:36,295 AND TRANSFORMATIONAL THINGS HOW 4799 03:51:36,295 --> 03:51:39,631 WE TREAT PATIENTS. 4800 03:51:39,631 --> 03:51:46,905 AND WHETHER THEY'RE IN A REAL OR 4801 03:51:46,905 --> 03:51:47,906 URBAN SETTING. 4802 03:51:47,906 --> 03:51:51,009 >> I'LL TRY TO RESPOND TO YOUR 4803 03:51:51,009 --> 03:51:51,276 QUESTION. 4804 03:51:51,276 --> 03:51:57,115 SO I WOULD OFFER THAT WITH EACH 4805 03:51:57,115 --> 03:51:59,751 CYCLE OF FUNDING NIDCR HAS 4806 03:51:59,751 --> 03:52:03,121 PERFORMED AN INDEPENDENT REVIEW 4807 03:52:03,121 --> 03:52:13,665 OR ASSESSMENT OR EVALUATION OF 4808 03:52:15,200 --> 03:52:25,677 THE CYCLE AND THERE MAY NOT BE A 4809 03:52:31,350 --> 03:52:35,921 LOT OF DETAIL BUT THE WAY I'D 4810 03:52:35,921 --> 03:52:40,392 VIEW THIS IS IN GENERAL AND IT'S 4811 03:52:40,392 --> 03:52:42,094 PROMOTED A MORE CONSERVATIVE 4812 03:52:42,094 --> 03:52:43,395 APPROACH TO ORAL HEALTH CARE AND 4813 03:52:43,395 --> 03:52:44,463 ON PARTICULAR TOPICS THAT HAVE 4814 03:52:44,463 --> 03:52:50,068 BEEN STUDIED IN THE NETWORK. 4815 03:52:50,068 --> 03:52:52,738 SO AS DR. DICKINSON HAS 4816 03:52:52,738 --> 03:52:54,473 MENTIONED THERE'S THE QUESTION 4817 03:52:54,473 --> 03:52:55,607 DO YOU TREAT OR NOT TREAT A 4818 03:52:55,607 --> 03:52:58,176 TOOTH OR TREAT OR NOT TREAT A 4819 03:52:58,176 --> 03:52:58,443 CONDITION. 4820 03:52:58,443 --> 03:53:03,115 HOW DO YOU BEST MANAGE IT? 4821 03:53:03,115 --> 03:53:06,685 TAKEN TOGETHER THE RESEARCH HAS 4822 03:53:06,685 --> 03:53:14,426 SHOWN ADVANTAGE TO CONSERVATIVE 4823 03:53:14,426 --> 03:53:19,131 CARE TO LESS INVASIVE TREATMENT 4824 03:53:19,131 --> 03:53:21,500 AND MARCHING IN A LESS INVASIVE 4825 03:53:21,500 --> 03:53:22,134 APPROACH. 4826 03:53:22,134 --> 03:53:23,568 I WOULD OFFER THAT WITHOUT 4827 03:53:23,568 --> 03:53:25,504 GETTING INTO A LOT OF SPECIFICS 4828 03:53:25,504 --> 03:53:30,175 ABOUT EACH PARTICULAR TOPIC. 4829 03:53:30,175 --> 03:53:39,117 I THINK THAT'S PRETTY PROFOUND 4830 03:53:39,117 --> 03:53:47,526 PERSONALLY. 4831 03:53:47,526 --> 03:53:49,528 >> I DON'T KNOW HOW MANY 4832 03:53:49,528 --> 03:53:50,095 DENTISTS ARE IN THE UNITED 4833 03:53:50,095 --> 03:53:52,097 STATES OR WORLD BUT HOW DO WE 4834 03:53:52,097 --> 03:53:55,634 THEN TAKE THE STATEMENT AND YOUR 4835 03:53:55,634 --> 03:53:57,469 FINDINGS THAT YOU JUST DISCUSSED 4836 03:53:57,469 --> 03:53:58,003 ABOUT MORE CONSERVATIVE 4837 03:53:58,003 --> 03:53:59,204 TREATMENT AND GET THAT TO ALL 4838 03:53:59,204 --> 03:54:01,306 THE DENTISTS AROUND THE COUNTRY? 4839 03:54:01,306 --> 03:54:05,911 THAT'S WHERE YOU'LL MAYBE THE 4840 03:54:05,911 --> 03:54:06,144 IMPACT. 4841 03:54:06,144 --> 03:54:07,913 >> I AGREE. 4842 03:54:07,913 --> 03:54:11,683 IT MAY BE A LARGER ISSUE BUT 4843 03:54:11,683 --> 03:54:14,019 CERTAINLY WE KNOW THIS BEGETS 4844 03:54:14,019 --> 03:54:16,488 PUBLICATIONS AN MANY HAVE BEEN 4845 03:54:16,488 --> 03:54:18,757 IN THOSE JOURNALS OF INTEREST TO 4846 03:54:18,757 --> 03:54:21,126 THE ORAL HEALTH COMMUNITIES SUCH 4847 03:54:21,126 --> 03:54:23,061 AS THE JOURNAL OF THE AMERICAN 4848 03:54:23,061 --> 03:54:28,166 DENTAL ASSOCIATION IN SOME CASES 4849 03:54:28,166 --> 03:54:33,872 PERHAPS WORK THAT HAS 4850 03:54:33,872 --> 03:54:36,708 CONTRIBUTED TO GUIDELINES WHICH 4851 03:54:36,708 --> 03:54:41,413 OF COURSE THE WORK OF GUIDELINE 4852 03:54:41,413 --> 03:54:46,418 DEVELOPMENT IS COMPLEX AND THAT 4853 03:54:46,418 --> 03:54:48,086 MIGHT SPEAK TO A LITTLE BIT MORE 4854 03:54:48,086 --> 03:54:49,855 DIRECTLY TO OFFERING CLINICAL 4855 03:54:49,855 --> 03:54:51,490 CARE BASED ON CERTAIN 4856 03:54:51,490 --> 03:54:51,923 GUIDELINES. 4857 03:54:51,923 --> 03:54:55,894 I THINK IN OTHER CASES IT MIGHT 4858 03:54:55,894 --> 03:54:59,798 BE BEST PRACTICES BASED UPON 4859 03:54:59,798 --> 03:55:04,036 THAT WHICH HAS BEEN IN THE ORAL 4860 03:55:04,036 --> 03:55:06,505 HEALTH LITERATURE. 4861 03:55:06,505 --> 03:55:10,142 AS DR. DICKINSON MENTIONED THERE 4862 03:55:10,142 --> 03:55:13,011 MAY BE OTHER WAYS TO DISSEMINATE 4863 03:55:13,011 --> 03:55:17,582 INFORMATION FROM THE PBRN TO THE 4864 03:55:17,582 --> 03:55:19,251 PRACTICING COMMUNITY. 4865 03:55:19,251 --> 03:55:19,918 CERTAINLY THAT'S SOMETHING THAT 4866 03:55:19,918 --> 03:55:21,086 CAN BE EXPLORED IN THE NEXT 4867 03:55:21,086 --> 03:55:31,196 CYCLE. 4868 03:55:32,531 --> 03:55:35,534 IT'S GOES BEYOND THE LITERATURE 4869 03:55:35,534 --> 03:55:39,137 PUB LUSHED THROUGH THE -- 4870 03:55:39,137 --> 03:55:42,374 PUBLISHED IN THE PBRN AND 4871 03:55:42,374 --> 03:55:46,344 THROUGH ORAL HEALTH IN GENERAL. 4872 03:55:46,344 --> 03:55:49,614 >> I WANTED TO RESPOND HOW DO WE 4873 03:55:49,614 --> 03:55:50,549 DISSEMINATE INFORMATION. 4874 03:55:50,549 --> 03:55:52,651 I THINK WE HEARD EARLIER TODAY 4875 03:55:52,651 --> 03:55:57,122 ABOUT TRYING TO ENGAGE OUR 4876 03:55:57,122 --> 03:56:00,425 DENTAL STUDENTS AND 4877 03:56:00,425 --> 03:56:02,727 UNDERSTANDING HOW PBRN'S WORK 4878 03:56:02,727 --> 03:56:05,330 AND BACK TO YOU PAUL AS THE DEAN 4879 03:56:05,330 --> 03:56:06,698 AND THE STUDENTS BECOME ENGAGED 4880 03:56:06,698 --> 03:56:10,135 AND KNOW ABOUT THIS ACTIVITY THE 4881 03:56:10,135 --> 03:56:11,269 MORE THAT PAY ATTENTION TO WHAT 4882 03:56:11,269 --> 03:56:13,205 COMES FROM THE ACTIVITY. 4883 03:56:13,205 --> 03:56:15,107 WE CAN DO THAT AT OUR DENTAL 4884 03:56:15,107 --> 03:56:19,578 SCHOOLS AND MAKE SURE THE 4885 03:56:19,578 --> 03:56:22,848 STUDENTS ARE AWARE AND WE'RE ALL 4886 03:56:22,848 --> 03:56:24,249 TEACHING EVIDENCE-BASED 4887 03:56:24,249 --> 03:56:25,383 DENTISTRY IT'S JUST ANOTHER 4888 03:56:25,383 --> 03:56:27,686 ASPECT OF THAT TO PARTICIPATE IF 4889 03:56:27,686 --> 03:56:31,923 THEY CAN AND AT THE LEAST TO BE 4890 03:56:31,923 --> 03:56:32,924 AWARE OF THE SYSTEMS GOING ON 4891 03:56:32,924 --> 03:56:39,631 AND THE OUTCOMES. 4892 03:56:39,631 --> 03:56:40,298 >> VERY GOOD THANK YOU. 4893 03:56:40,298 --> 03:56:42,367 GREAT POINT. 4894 03:56:42,367 --> 03:56:44,369 WE HEARD ABOUT NIDCR'S OTHER 4895 03:56:44,369 --> 03:56:45,370 INITIATIVE WHERE PRACTICE-BASED 4896 03:56:45,370 --> 03:56:48,540 RESEARCH IS BEING CONDUCTED IN 4897 03:56:48,540 --> 03:56:50,342 DENTAL SCHOOL. 4898 03:56:50,342 --> 03:56:51,143 HOPEFULLY THERE'LL BE 4899 03:56:51,143 --> 03:56:52,310 DOVETAILING BETWEEN THE EFFORTS. 4900 03:56:52,310 --> 03:56:55,914 >> ARE WE READY TO VOTE ON THE 4901 03:56:55,914 --> 03:57:03,889 CONCEPT? 4902 03:57:03,889 --> 03:57:04,456 >> SO MOVED. 4903 03:57:04,456 --> 03:57:05,490 >> WOULD ANYONE LIKE TO SECOND? 4904 03:57:05,490 --> 03:57:11,596 >> I SECOND. 4905 03:57:11,596 --> 03:57:16,935 >> ALL IN FAVOR. 4906 03:57:16,935 --> 03:57:17,402 >> YES. 4907 03:57:17,402 --> 03:57:23,909 >> ANY OPPOSED? 4908 03:57:23,909 --> 03:57:27,112 ALL RIGHT. 4909 03:57:27,112 --> 03:57:29,247 THANK YOU VERY MUCH. 4910 03:57:29,247 --> 03:57:32,417 WE'LL MOVE ON TO THE NEXT 4911 03:57:32,417 --> 03:57:41,159 CONCEPT BY DR. ORLANDO LOPEZ. 4912 03:57:41,159 --> 03:57:43,128 >> GREETINGS AND GOOD AFTERNOON. 4913 03:57:43,128 --> 03:57:44,296 EVERYBODY HEAR ME OKAY? 4914 03:57:44,296 --> 03:57:54,839 >> CAN YOU TURN YOUR MONITOR ON? 4915 03:57:55,674 --> 03:57:58,410 >> THANK YOU FOR ALLOWING ME TO 4916 03:57:58,410 --> 03:58:03,215 SEEK COUNCIL'S CLEARANCE FOR THE 4917 03:58:03,215 --> 03:58:07,953 CONCEPT TO REVOLUTION I'D 4918 03:58:07,953 --> 03:58:09,988 DENTAL, ORAL AND CRANIOFACIAL 4919 03:58:09,988 --> 03:58:12,524 MEDICINE AND THIS IS FOR DIGITAL 4920 03:58:12,524 --> 03:58:14,326 TWINS AND ADVANCING INNOVATION 4921 03:58:14,326 --> 03:58:16,628 IN OPTIMIZING CLINICAL OUTCOME 4922 03:58:16,628 --> 03:58:18,496 IN DENTAL, ORAL AND CRANIOFACIAL 4923 03:58:18,496 --> 03:58:25,837 MEDICINE AND I SERVE AS THE 4924 03:58:25,837 --> 03:58:27,906 COORDINATOR FOR THE SMALL 4925 03:58:27,906 --> 03:58:33,144 BUSINESS PROGRAM DEVELOPED WITH 4926 03:58:33,144 --> 03:58:36,715 COLLEAGUES DR. WAN AND DR. OKI 4927 03:58:36,715 --> 03:58:39,584 WHO DIRECTS THE DATA SCIENCE 4928 03:58:39,584 --> 03:58:40,218 BIOLOGY AND BIO INFORMATICS 4929 03:58:40,218 --> 03:58:50,362 PROGRAM. 4930 03:58:55,900 --> 03:58:57,402 AND BY LEVERAGING DIGITAL TWINS 4931 03:58:57,402 --> 03:59:01,239 TECHNOLOGIES WE AIM TO 4932 03:59:01,239 --> 03:59:03,341 ACCELERATE CUTTING EDGE RESEARCH 4933 03:59:03,341 --> 03:59:07,912 TO PATIENT CARE AM KAPPLICATIOND 4934 03:59:07,912 --> 03:59:09,814 THEY'RE EXPECTED TO SERVE AS 4935 03:59:09,814 --> 03:59:11,983 POWERFUL TOOLS FOR PREDICTIVE 4936 03:59:11,983 --> 03:59:13,885 TESTING AND INNOVATION PUSHING 4937 03:59:13,885 --> 03:59:15,620 THE BOUNDARIES OF WHAT'S NOW 4938 03:59:15,620 --> 03:59:18,490 POSSIBLE IN DENTAL, ORAL AND 4939 03:59:18,490 --> 03:59:19,891 CRANIOFACIAL MEDICINE. 4940 03:59:19,891 --> 03:59:23,895 SECOND, WE LOOK TO TRANSFORMING 4941 03:59:23,895 --> 03:59:25,997 TREATMENTS. 4942 03:59:25,997 --> 03:59:31,803 IN DOING SO WE INTEND TO HAVE 4943 03:59:31,803 --> 03:59:35,907 DIGITAL TWIN TECHNOLOGIES TO 4944 03:59:35,907 --> 03:59:37,575 REPLICATE SCENARIOS TO INTEGRATE 4945 03:59:37,575 --> 03:59:39,177 WITH REAL TIME DATA AND 4946 03:59:39,177 --> 03:59:41,680 PREDICTIVE ANALYTICS AND IN 4947 03:59:41,680 --> 03:59:45,083 DOING THIS WE'LL HAVE A 4948 03:59:45,083 --> 03:59:46,584 CAPABILITY TO REVOLUTIONIZE 4949 03:59:46,584 --> 03:59:48,687 PLANNING MAKING IT MORE PRECISE 4950 03:59:48,687 --> 03:59:51,156 THAN EVER BEFORE. 4951 03:59:51,156 --> 03:59:53,692 THIRD, OPTIMIZING PATIENT 4952 03:59:53,692 --> 03:59:57,429 OUTCOMES BY TRADITIONAL METHODS 4953 03:59:57,429 --> 03:59:59,497 THROUGH INFORMATION WE SEEK TO 4954 03:59:59,497 --> 04:00:02,200 ENHANCE DIAGNOSTIC ACCURACY, 4955 04:00:02,200 --> 04:00:07,205 OPTIMIZE CARE DELIVERY AND 4956 04:00:07,205 --> 04:00:07,906 ENABLE CONTINUOUS PATIENT 4957 04:00:07,906 --> 04:00:09,941 SPECIFIC ADJUSTMENTS LEADING TO 4958 04:00:09,941 --> 04:00:10,842 IMPROVED EFFICIENCY AND 4959 04:00:10,842 --> 04:00:11,376 EFFECTIVENESS IN PATIENT 4960 04:00:11,376 --> 04:00:17,115 OUTCOMES. 4961 04:00:17,115 --> 04:00:19,984 IN TERMS OF BACKGROUND, IT IS 4962 04:00:19,984 --> 04:00:24,956 BROADLY ACCEPTED PRACTICES IN 4963 04:00:24,956 --> 04:00:27,492 ORAL, DENTAL AND CRANIOFACIAL 4964 04:00:27,492 --> 04:00:29,994 MEDICINE RELY ON GENERALIZED 4965 04:00:29,994 --> 04:00:32,464 APPROACHES AND CASES WHICH CAN 4966 04:00:32,464 --> 04:00:34,566 LEAD TO SUBOPTIMAL OUTCOMES AND 4967 04:00:34,566 --> 04:00:35,800 PATIENT EXPERIENCES. 4968 04:00:35,800 --> 04:00:39,070 THIS IS WHERE DIGITAL TWINS 4969 04:00:39,070 --> 04:00:49,614 OFFER A PARADIGM SHIFT AND BASED 4970 04:00:53,818 --> 04:00:56,788 NATIONAL ACADEMIES WITH A 4971 04:00:56,788 --> 04:01:04,596 DIGITAL TWIN CAN BE KEY DEFINED 4972 04:01:04,596 --> 04:01:05,964 AND UPDATED WITH DATA TO PREDICT 4973 04:01:05,964 --> 04:01:08,500 OUTCOME. 4974 04:01:08,500 --> 04:01:10,969 THIS TECHNOLOGY ALLOWS US TO 4975 04:01:10,969 --> 04:01:13,271 MODEL A PATIENT'S SPECIFIC 4976 04:01:13,271 --> 04:01:14,906 STRUCTURES AND CONDITIONS 4977 04:01:14,906 --> 04:01:15,940 PROVIDING LEVEL OF PRECISION 4978 04:01:15,940 --> 04:01:19,711 TRADITIONAL METHODS CANNOT 4979 04:01:19,711 --> 04:01:19,911 MATCH. 4980 04:01:19,911 --> 04:01:23,915 BY CAPTURING DIGITAL MODELS OF A 4981 04:01:23,915 --> 04:01:28,052 PATIENT'S ORAL ANATOMY AND 4982 04:01:28,052 --> 04:01:30,455 INTEGRATING THEM WITH REAL TIME 4983 04:01:30,455 --> 04:01:32,957 DATA WE CAN OPTIMIZE PLANNING 4984 04:01:32,957 --> 04:01:33,958 BEFORE IMPLEMENTATION. 4985 04:01:33,958 --> 04:01:35,493 THIS INTERACTION BETWEEN THE 4986 04:01:35,493 --> 04:01:40,899 VIRTUAL AND PHYSICAL MODELS 4987 04:01:40,899 --> 04:01:43,101 ENABLES ENHANCED TREATMENT OF 4988 04:01:43,101 --> 04:01:46,905 THE PATIENT'S TREATMENT AND 4989 04:01:46,905 --> 04:01:48,840 EFFECTIVENESS AND IMPROVE 4990 04:01:48,840 --> 04:01:50,041 PATIENT SATISFACTION IN THE 4991 04:01:50,041 --> 04:02:00,385 SHORT AND LONG TERM. 4992 04:02:03,788 --> 04:02:05,990 AND THE VIRTUAL MODELS REPLICATE 4993 04:02:05,990 --> 04:02:08,359 AN INDIVIDUAL'S HEALTH STATUS BY 4994 04:02:08,359 --> 04:02:10,295 INTEGRATING A WIDE RANGE OF DATA 4995 04:02:10,295 --> 04:02:15,200 SOURCES RANGING FROM MEDICAL 4996 04:02:15,200 --> 04:02:17,635 RECORDS, IMAGING DATA TO GENETIC 4997 04:02:17,635 --> 04:02:19,871 INFORMATION ON ENVIRONMENTAL 4998 04:02:19,871 --> 04:02:22,807 FACTORS AND THE MODELS NOT ONLY 4999 04:02:22,807 --> 04:02:23,908 ENABLE PERSONALIZED TREATMENT 5000 04:02:23,908 --> 04:02:27,912 PLAN BUT PREDICTIVE ANALYTICS 5001 04:02:27,912 --> 04:02:31,649 FOR THE DISEASE PROGRESSION AND 5002 04:02:31,649 --> 04:02:32,217 OPTIMIZATION OF HEALTH CARE 5003 04:02:32,217 --> 04:02:42,393 DELIVERY. 5004 04:02:43,428 --> 04:02:46,064 THERE'S A DYNAMIC INTERACTION 5005 04:02:46,064 --> 04:02:48,066 BETWEEN THE PHYSICAL AND VIRTUAL 5006 04:02:48,066 --> 04:02:50,201 MODEL. 5007 04:02:50,201 --> 04:02:52,437 IN THE CONTEXT OF CRANIOFACIAL 5008 04:02:52,437 --> 04:02:55,306 MEDICINE, THE EXAMPLE TA COMES 5009 04:02:55,306 --> 04:02:59,911 TO MIND IS DENTAL IMPLANT 5010 04:02:59,911 --> 04:03:03,181 OPTIMIZATION AND DIGITAL TWINS 5011 04:03:03,181 --> 04:03:07,685 CAN LOOK HOW TO IMPACT OUTCOMES 5012 04:03:07,685 --> 04:03:09,053 AND ALLOWING FOR FINE TUNING 5013 04:03:09,053 --> 04:03:11,890 BEFORE A PHYSICAL PROCEDURE IS 5014 04:03:11,890 --> 04:03:22,100 UNDERTAKEN. 5015 04:03:23,034 --> 04:03:31,910 A 5016 04:03:31,910 --> 04:03:34,612 AND AND THERE WERE DIFFICULTIES 5017 04:03:34,612 --> 04:03:38,182 IN DIAGNOSIS AND TREATMENT, 5018 04:03:38,182 --> 04:03:39,183 PLANNING FOR COMPLEX CONDITIONS 5019 04:03:39,183 --> 04:03:43,621 LIKE DISORDERS AND ORAL CANCERS 5020 04:03:43,621 --> 04:03:47,258 AND ISSUES RELATED TO DATA 5021 04:03:47,258 --> 04:03:49,761 PRIVACY, INFRASTRUCTURE AND 5022 04:03:49,761 --> 04:03:51,195 INTEROPERABILITY AND IT PRESENTS 5023 04:03:51,195 --> 04:03:53,431 OPPORTUNITIES AND BY ADDRESSING 5024 04:03:53,431 --> 04:03:55,867 THE GAP WE CAN UNDERSTAND OUR 5025 04:03:55,867 --> 04:03:58,670 COMPLEX PROCESSES, OPTIMIZE 5026 04:03:58,670 --> 04:04:00,605 TREATMENT PLANS AND ENHANCE 5027 04:04:00,605 --> 04:04:02,073 INTERVENTION ACROSS SPATIAL, 5028 04:04:02,073 --> 04:04:11,849 TEMPORAL AND BIOLOGIC SCALE. 5029 04:04:11,849 --> 04:04:14,218 AND CATALYZING INNOVATION AND 5030 04:04:14,218 --> 04:04:19,924 THE CYCLES OF DENTAL, ORAL AND 5031 04:04:19,924 --> 04:04:30,368 CRANIOFACIAL INNOVATIONS. 5032 04:04:32,804 --> 04:04:37,742 AND OPPORTUNITIES IN THE FIELD 5033 04:04:37,742 --> 04:04:37,976 ITSELF. 5034 04:04:37,976 --> 04:04:40,578 SO FIRST DENTAL, ORAL AND 5035 04:04:40,578 --> 04:04:41,045 CRANIOFACIAL TOOLS. 5036 04:04:41,045 --> 04:04:47,885 WE CAN USE DIGITAL TWINS TO 5037 04:04:47,885 --> 04:04:51,055 ACCELERATE APPROACHED AND 5038 04:04:51,055 --> 04:04:56,427 OPTIMIZING THE NEW INNOVATIONS. 5039 04:04:56,427 --> 04:04:59,897 THERE'S BROAD OPPORTUNITIES FOR 5040 04:04:59,897 --> 04:05:03,201 OPPORTUNITIES IN DIGITAL TWINS 5041 04:05:03,201 --> 04:05:05,303 INCLUDING OPTIMIZING 5042 04:05:05,303 --> 04:05:07,905 INTERVENTIONS AND TREATMENTS FOR 5043 04:05:07,905 --> 04:05:12,543 TEMPORAL MANDIBULAR DISORDERS 5044 04:05:12,543 --> 04:05:14,445 AND ORAL CANCERS AND DIGITAL 5045 04:05:14,445 --> 04:05:16,914 TWINS ALSO OFFER POTENTIAL TO 5046 04:05:16,914 --> 04:05:19,884 ENHANCE EARLY DETECTION 5047 04:05:19,884 --> 04:05:21,452 CAPABILITIES PARTICULARLY 5048 04:05:21,452 --> 04:05:24,956 ADDRESSING CONDITIONS SUCH AS 5049 04:05:24,956 --> 04:05:25,590 TEMPORAL MANDIBULAR DISORDERS 5050 04:05:25,590 --> 04:05:27,892 AND ORAL CANCERS. 5051 04:05:27,892 --> 04:05:33,197 THIRD, OPPORTUNITIES IN CLINICAL 5052 04:05:33,197 --> 04:05:37,602 WORK FLOW INTEGRATION INTO 5053 04:05:37,602 --> 04:05:39,904 ROUTINE DENTAL CARE AND TRAINING 5054 04:05:39,904 --> 04:05:42,206 IS CRUCIAL BUT OFFERING USER 5055 04:05:42,206 --> 04:05:44,208 FRIENDLY INTERFACES AN TRAINING 5056 04:05:44,208 --> 04:05:47,345 WE CAN ENSURE THE TECHNOLOGIES 5057 04:05:47,345 --> 04:05:50,081 ARE INTEGRATED INTO DAILY 5058 04:05:50,081 --> 04:05:51,182 PRACTICE. 5059 04:05:51,182 --> 04:05:53,284 FOURTH, LONG-TERM IMPACT 5060 04:05:53,284 --> 04:05:57,021 EVALUATION WILL BE ABLE TO HAVE 5061 04:05:57,021 --> 04:05:57,655 AN OPPORTUNITY TO ASSESS HOW 5062 04:05:57,655 --> 04:05:59,590 DIGITAL TWINS BASED APPROACHES 5063 04:05:59,590 --> 04:06:02,894 MAY IMPROVE TREATMENT POSITION, 5064 04:06:02,894 --> 04:06:03,561 EFFICIENCY, PATIENT SATISFACTION 5065 04:06:03,561 --> 04:06:09,200 AND CLINICAL OUTCOMES AND 5066 04:06:09,200 --> 04:06:11,903 COMMUNITY-BASED APPLICATIONS 5067 04:06:11,903 --> 04:06:22,380 WILL ALLOW US TO CUSTOMIZE 5068 04:06:23,347 --> 04:06:23,548 OUTCOMES. 5069 04:06:23,548 --> 04:06:27,185 INTEGRATION OF THE DIGITAL TWIN 5070 04:06:27,185 --> 04:06:29,620 TECHNOLOGIES TO DENTAL, ORAL, 5071 04:06:29,620 --> 04:06:31,656 CRANIOFACIAL MEDICINE IS NOT 5072 04:06:31,656 --> 04:06:34,859 ONLY A TECHNICAL ADVANCEMENT BUT 5073 04:06:34,859 --> 04:06:38,463 OFFERING A PARADIGM SHIFT AND 5074 04:06:38,463 --> 04:06:41,332 MOVE TO FUTURE CARE THAT'S MORE 5075 04:06:41,332 --> 04:06:42,967 PRECISE, PERSONALIZED AND 5076 04:06:42,967 --> 04:06:43,901 EFFECTIVE THAN EVER BEFORE. 5077 04:06:43,901 --> 04:06:48,106 I INVITE YOU TO JOIN ME IN 5078 04:06:48,106 --> 04:06:49,907 SUPPORTING THE INITIATIVE AND 5079 04:06:49,907 --> 04:06:52,777 TRANSFORM PATIENT CARE AND 5080 04:06:52,777 --> 04:06:54,445 OUTCOMES IN MEDICINE. 5081 04:06:54,445 --> 04:06:59,484 THANK YOU VERY MUCH FOR YOUR 5082 04:06:59,484 --> 04:07:07,892 CONSIDERATION. 5083 04:07:07,892 --> 04:07:14,031 THANK YOU. 5084 04:07:14,031 --> 04:07:19,003 >> THANK YOU, DR. LOPEZ FOR 5085 04:07:19,003 --> 04:07:22,540 SHARING THIS CUTTING EDGE 5086 04:07:22,540 --> 04:07:23,875 CONCEPT ON DIGITAL TWINS AND I 5087 04:07:23,875 --> 04:07:26,778 AM TRULY EXCITED TO SEE THIS 5088 04:07:26,778 --> 04:07:36,320 WORK BEING ADVANCED IN NIDCR. 5089 04:07:36,320 --> 04:07:39,190 OUT WAS ESTABLISHED IN 5090 04:07:39,190 --> 04:07:40,825 ENGINEERING A DIGITAL TWINS ON 5091 04:07:40,825 --> 04:07:42,593 MY CAR COULD BE BASED ON THE 5092 04:07:42,593 --> 04:07:45,196 ENGINE, THE MATERIALS, THE 5093 04:07:45,196 --> 04:07:47,398 FORCES APPLIED ON THOSE 5094 04:07:47,398 --> 04:07:48,866 COMPONENTS, COMBINED WITH REAL 5095 04:07:48,866 --> 04:07:51,903 TIME DATA PULLED IN FROM ALL THE 5096 04:07:51,903 --> 04:07:53,070 SENSORS IN YOUR VEHICLE. 5097 04:07:53,070 --> 04:07:55,907 AND YOU COULD USE IT TO SEE HOW 5098 04:07:55,907 --> 04:07:59,443 THAT ENGINE WOULD PERFORM IN 5099 04:07:59,443 --> 04:08:00,344 DIFFERENT CONDITIONS LIKE COLD 5100 04:08:00,344 --> 04:08:01,779 WEATHER WE DON'T GET IN 5101 04:08:01,779 --> 04:08:03,080 TENNESSEE OR USE IT TO PREDICT 5102 04:08:03,080 --> 04:08:04,816 WA PARTS OF THE ENGINE MIGHT 5103 04:08:04,816 --> 04:08:10,988 WEAR OUT FASTER. 5104 04:08:10,988 --> 04:08:12,390 IT SEEMS WE SHOULD BE ABLE TO 5105 04:08:12,390 --> 04:08:14,992 APPLY THE CONCEPTS IN ORAL 5106 04:08:14,992 --> 04:08:16,060 HEALTH CARE AND RESEARCH. 5107 04:08:16,060 --> 04:08:17,995 AS YOU'VE DESCRIBED IT'S PRETTY 5108 04:08:17,995 --> 04:08:19,597 NOVEL AND UNTESTED IN MEDICINE 5109 04:08:19,597 --> 04:08:21,199 SO FAR WHICH PRESENTS A FEW MORE 5110 04:08:21,199 --> 04:08:27,205 CHALLENGES. 5111 04:08:27,205 --> 04:08:29,207 THE DEFINITION AND OUR 5112 04:08:29,207 --> 04:08:30,174 UNDERSTANDING OF DIGITAL TWINS 5113 04:08:30,174 --> 04:08:31,776 IN HEALTH IS STILL INFLUX. 5114 04:08:31,776 --> 04:08:33,511 I THINK THE METHOD OF 5115 04:08:33,511 --> 04:08:35,112 IMPLEMENTING AND EVALUATING ARE 5116 04:08:35,112 --> 04:08:36,013 NOT CLEARLY ESTABLISHED. 5117 04:08:36,013 --> 04:08:42,386 SO I WOULD HAPPY TO SEE THE 5118 04:08:42,386 --> 04:08:45,523 EMPHASIS ON THE IMPORTANCE OF 5119 04:08:45,523 --> 04:08:50,761 WHY UP DATING BUT MAY BE HARDER 5120 04:08:50,761 --> 04:08:53,364 ATTAIN THE SCALES OF 5121 04:08:53,364 --> 04:08:58,436 AVAILABILITY AND IMPACT AND 5122 04:08:58,436 --> 04:08:59,170 COMMUNITY-BASED APPLICATIONS. 5123 04:08:59,170 --> 04:09:04,642 THE MAIN THING I'VE THOUGHT 5124 04:09:04,642 --> 04:09:09,046 ABOUT PATIENT DATA PRIVACY AND 5125 04:09:09,046 --> 04:09:10,915 CYBER SECURITY AND HAVE TO BE 5126 04:09:10,915 --> 04:09:12,650 CRITICAL COMPONENTS BECAUSE DATA 5127 04:09:12,650 --> 04:09:15,219 ABOUT MY CAR ENGINE IS NOT THE 5128 04:09:15,219 --> 04:09:23,294 SAME AS DATA ON MY HEALTH AND 5129 04:09:23,294 --> 04:09:26,731 THERE'S ALSO UNEXPLORED ONLY 5130 04:09:26,731 --> 04:09:28,866 CAL, LEGAL AND SOCIAL 5131 04:09:28,866 --> 04:09:29,433 IMPLICATIONS WE DON'T QUITE 5132 04:09:29,433 --> 04:09:32,904 UNDERSTAND YET. 5133 04:09:32,904 --> 04:09:34,605 BUT BASED ON YOUR PRESENTATION I 5134 04:09:34,605 --> 04:09:36,240 CAN TELL THESE THOUGHTS ARE ALSO 5135 04:09:36,240 --> 04:09:37,575 ON YOUR RADAR. 5136 04:09:37,575 --> 04:09:40,544 I DO WANT TO RECOGNIZE THAT THIS 5137 04:09:40,544 --> 04:09:43,080 CONCEPT APPEARS TO BUILD 5138 04:09:43,080 --> 04:09:45,016 DIRECTLY ON OPPORTUNITIES 5139 04:09:45,016 --> 04:09:46,751 OUTLINED BY THE DATA SCIENCE 5140 04:09:46,751 --> 04:09:47,919 STRATEGY WORKING GROUP THAT 5141 04:09:47,919 --> 04:09:49,487 WE'VE HEARD ABOUT IN PRIOR 5142 04:09:49,487 --> 04:09:51,222 COUNCIL. 5143 04:09:51,222 --> 04:09:54,325 THEY CHALLENGED US TO FIND NEW 5144 04:09:54,325 --> 04:09:55,927 METHODOLOGICAL APPROACHES AND 5145 04:09:55,927 --> 04:09:56,928 THOUGH THEY DIDN'T MENTION 5146 04:09:56,928 --> 04:09:59,630 DIGITAL TWINS SPECIFICALLY, THEY 5147 04:09:59,630 --> 04:10:02,199 DID AND I QUOTE SAY SIMULATION 5148 04:10:02,199 --> 04:10:04,068 METHODS CAN FACILITATE THE 5149 04:10:04,068 --> 04:10:06,237 ASSESSMENT OF NOVEL AND COMPLEX 5150 04:10:06,237 --> 04:10:07,071 INTERVENTIONS TO TACKLE ORAL 5151 04:10:07,071 --> 04:10:11,075 HEALTH INEQUALITIES INCLUDING 5152 04:10:11,075 --> 04:10:11,709 SCALABILITY, EFFECTIVENESS AND 5153 04:10:11,709 --> 04:10:12,843 LONG-TERM SUSTAINABILITY. 5154 04:10:12,843 --> 04:10:14,545 I THINK THAT IS WHAT THIS 5155 04:10:14,545 --> 04:10:19,884 CONCEPT IS TRULY AIMING FOR. 5156 04:10:19,884 --> 04:10:23,254 BECAUSE THESE APPROACHES ARE NEW 5157 04:10:23,254 --> 04:10:26,757 THE CONCEPT IS INHERENTLY MORE 5158 04:10:26,757 --> 04:10:28,526 RISKY BUT WILL CATALYZE 5159 04:10:28,526 --> 04:10:29,560 INNOVATION AND HAS THE POTENTIAL 5160 04:10:29,560 --> 04:10:31,128 TO HAVE A LASTING IMPACT IN OUR 5161 04:10:31,128 --> 04:10:31,729 RESEARCH FIELD. 5162 04:10:31,729 --> 04:10:34,165 I FULLY SUPPORT THE CONCEPT. 5163 04:10:34,165 --> 04:10:34,632 >> THANK YOU SO MUCH. 5164 04:10:34,632 --> 04:10:45,109 I APPRECIATE YOUR COMMENTS. 5165 04:10:46,944 --> 04:10:48,312 >> IT'S A BALANCE OF EXCITEMENT 5166 04:10:48,312 --> 04:10:50,414 AND LIMITATIONS. 5167 04:10:50,414 --> 04:10:55,519 THIS IS CUTTING EDGE. 5168 04:10:55,519 --> 04:10:58,689 VERY NEW EVEN IN THE MEDICAL 5169 04:10:58,689 --> 04:11:02,093 FIELD WITH ONCOLOGY AND 5170 04:11:02,093 --> 04:11:03,194 CARDIOLOGY IS WHERE DIGITAL 5171 04:11:03,194 --> 04:11:08,332 TWINS ARE A LITTLE BIT MORE 5172 04:11:08,332 --> 04:11:08,599 ADVANCED. 5173 04:11:08,599 --> 04:11:12,670 I DO SHARE SOME CHALLENGES AND 5174 04:11:12,670 --> 04:11:14,405 CONCERNS STEPH BROUGHT UP. 5175 04:11:14,405 --> 04:11:21,812 THE MAJOR ONE YOU KNOW IS THE 5176 04:11:21,812 --> 04:11:22,446 BIOLOG 5177 04:11:22,446 --> 04:11:25,216 BIOLOGICAL HETEROGENEITY OF 5178 04:11:25,216 --> 04:11:27,251 PATIENTS IS A CHALLENGE FOR 5179 04:11:27,251 --> 04:11:29,420 DIGITAL TWINS TECHNOLOGY AND 5180 04:11:29,420 --> 04:11:31,856 INTEGRATION. 5181 04:11:31,856 --> 04:11:33,491 YOU'RE TALKING ABOUT MULTISCALE 5182 04:11:33,491 --> 04:11:37,028 AND YOU HAVE MANY LAYERS OF DATA 5183 04:11:37,028 --> 04:11:40,498 AND WILL PROBABLY NEED HIGHER 5184 04:11:40,498 --> 04:11:42,433 RESOLUTION MODELS TO BE 5185 04:11:42,433 --> 04:11:42,733 INTEGRATED. 5186 04:11:42,733 --> 04:11:48,239 I THINK IN TERMS OF CONCEPT I 5187 04:11:48,239 --> 04:11:50,941 THINK I'M SUPPORTIVE. 5188 04:11:50,941 --> 04:11:55,212 THE KEY POINT IS HOW WE FRAME 5189 04:11:55,212 --> 04:11:56,781 THIS TO BE VERY SPECIFIC. 5190 04:11:56,781 --> 04:11:59,250 MAYBE STARTING WITH 5191 04:11:59,250 --> 04:12:02,420 METHODOLOGISTS IS ONE WAY TO 5192 04:12:02,420 --> 04:12:03,254 START SINCE IT'S A NEW 5193 04:12:03,254 --> 04:12:09,760 TECHNOLOGY. 5194 04:12:09,760 --> 04:12:12,630 ONE SUGGESTION IS ORAL CANCER 5195 04:12:12,630 --> 04:12:14,098 TMD IS GREAT BUT WHY NOT 5196 04:12:14,098 --> 04:12:16,534 INFECTIOUS DISEASES. 5197 04:12:16,534 --> 04:12:19,904 THE MICROBIOME DATA IS EASY TO 5198 04:12:19,904 --> 04:12:24,241 COLLECT AND ABUNDANT AND CAN BE 5199 04:12:24,241 --> 04:12:25,342 STRATIFIED TO THE PATIENT'S 5200 04:12:25,342 --> 04:12:27,411 HEALTH COULD BE ANOTHER 5201 04:12:27,411 --> 04:12:29,246 POTENTIAL APPLICATION FOR 5202 04:12:29,246 --> 04:12:30,981 DIGITAL TWINS TO INCLUDE 5203 04:12:30,981 --> 04:12:31,482 INFECTIOUS DISEASES AND 5204 04:12:31,482 --> 04:12:38,956 MICROBIOME DATA. 5205 04:12:38,956 --> 04:12:41,926 UME NOT SURE IF ORTHODONTIC 5206 04:12:41,926 --> 04:12:45,830 PLACEMENT OR IMPLANT PLACEMENT 5207 04:12:45,830 --> 04:12:53,037 ARE WELL ESTABLISHED. 5208 04:12:53,037 --> 04:12:55,539 WE'RE DOING DENTISTRY IN THAT 5209 04:12:55,539 --> 04:12:55,806 AREA. 5210 04:12:55,806 --> 04:12:57,508 MAYBE ORAL CANCER TMD FOR SURE 5211 04:12:57,508 --> 04:13:00,277 BUT INFECTIOUS DISEASES COULD BE 5212 04:13:00,277 --> 04:13:02,847 ANOTHER AREA THAT COULD BE 5213 04:13:02,847 --> 04:13:03,881 INTEGRATED. 5214 04:13:03,881 --> 04:13:07,485 OVER ALL I FULLY SUPPORT THIS 5215 04:13:07,485 --> 04:13:09,120 CONCEPT. 5216 04:13:09,120 --> 04:13:10,488 MAYBE JUST FRAMING WHERE THE 5217 04:13:10,488 --> 04:13:12,756 FOCUS ARE FOR THE CONCEPT. 5218 04:13:12,756 --> 04:13:13,390 THAT WOULD BE MY ONLY 5219 04:13:13,390 --> 04:13:13,691 SUGGESTION. 5220 04:13:13,691 --> 04:13:19,363 THANK YOU. 5221 04:13:19,363 --> 04:13:22,399 >> EXCELLENT THANK YOU VERY 5222 04:13:22,399 --> 04:13:22,600 MUCH. 5223 04:13:22,600 --> 04:13:25,836 VERY INSIGHTFUL AND SUGGESTIONS. 5224 04:13:25,836 --> 04:13:27,304 THIS WILL PROVIDE ADDITIONAL 5225 04:13:27,304 --> 04:13:30,608 CONTEXT TO SOME OF THE CONCERNS 5226 04:13:30,608 --> 04:13:33,010 AND LIMITATIONS STEMMING FROM 5227 04:13:33,010 --> 04:13:33,644 THE NATIONAL ACADEMIES REPORT 5228 04:13:33,644 --> 04:13:36,614 THAT CAME OUT EARLIER THERE'S 5229 04:13:36,614 --> 04:13:38,249 BEEN A SIGNIFICANT AND ONE 5230 04:13:38,249 --> 04:13:41,218 RECOMMENDATION WAS FOR 5231 04:13:41,218 --> 04:13:42,052 COALESCENCE OF THE DIFFERENT 5232 04:13:42,052 --> 04:13:47,491 FEDERAL AGENCIES TO COME 5233 04:13:47,491 --> 04:13:48,125 TOGETHER SEE THE INFRASTRUCTURE 5234 04:13:48,125 --> 04:13:54,498 BEING DEVELOPED. 5235 04:13:54,498 --> 04:13:57,034 PART OF DIGITAL TWINS FAST TRACT 5236 04:13:57,034 --> 04:13:59,470 ACTION COMMITTEE BUT ENCOMPASSES 5237 04:13:59,470 --> 04:14:01,338 ALL DIFFERENT KINDS OF FEDERAL 5238 04:14:01,338 --> 04:14:04,909 AGENCIES THAT WILL BE LOOKING AT 5239 04:14:04,909 --> 04:14:06,911 THE DIGITAL TWINS FOR MANY 5240 04:14:06,911 --> 04:14:10,548 DIFFERENT DOMAINS. 5241 04:14:10,548 --> 04:14:12,016 THAT'S COMING IN THE FUTURE 5242 04:14:12,016 --> 04:14:14,084 WHERE WE'RE TALKING ABOUT HOW TO 5243 04:14:14,084 --> 04:14:19,056 BEST ADDRESS THE CRITICAL 5244 04:14:19,056 --> 04:14:19,890 INFRASTRUCTURE NEEDS REGARDING 5245 04:14:19,890 --> 04:14:21,292 DATA AND PRIVACY SECURITY. 5246 04:14:21,292 --> 04:14:23,961 THERE'S SOME FRAME WORKS WE'LL 5247 04:14:23,961 --> 04:14:24,929 BE ABLE TO LEVERAGE IN THE 5248 04:14:24,929 --> 04:14:27,064 DISCUSSION AND DEVELOPMENT OF 5249 04:14:27,064 --> 04:14:27,932 THE TOOLS. 5250 04:14:27,932 --> 04:14:34,138 WELL TAKEN IN TERMS OF A LOT OF 5251 04:14:34,138 --> 04:14:40,544 THE CONCERNS AND LOOKING FORWARD 5252 04:14:40,544 --> 04:14:42,313 TO EXCITING IMPLEMENTATION OF 5253 04:14:42,313 --> 04:14:43,013 THESE IN THE FUTURE. 5254 04:14:43,013 --> 04:14:45,316 >> WE HAVE TIME FOR MAYBE ONE 5255 04:14:45,316 --> 04:14:48,519 MORE COMMENT. 5256 04:14:48,519 --> 04:14:58,596 IF NOT WE CAN GO TO THE VOTING. 5257 04:14:58,596 --> 04:15:03,000 WOULD A MEMBER OF COUNCIL LIKE 5258 04:15:03,000 --> 04:15:05,302 TO MOTION TO APPROVE THE 5259 04:15:05,302 --> 04:15:05,536 CONCEPT. 5260 04:15:05,536 --> 04:15:07,905 >> I MORE TO APPROVE THE 5261 04:15:07,905 --> 04:15:09,940 CONCEPT, STEPHANIE DUDDA. 5262 04:15:09,940 --> 04:15:11,976 >> WOULD SOMEONE LIKE TO SECOND. 5263 04:15:11,976 --> 04:15:14,111 >> I SECOND. 5264 04:15:14,111 --> 04:15:20,417 MICHELLE KOO. 5265 04:15:20,417 --> 04:15:30,694 >> ALL IN FAVOR. 5266 04:15:33,597 --> 04:15:35,899 THANK YOU. 5267 04:15:35,899 --> 04:15:37,368 ANY OPPOSED? 5268 04:15:37,368 --> 04:15:39,303 THANK YOU, ORLANDO. 5269 04:15:39,303 --> 04:15:42,406 WE'LL MOVE TO THE THIRD CONCEPT 5270 04:15:42,406 --> 04:15:52,883 PRESENTED BY DR. BACCAGLINI. 5271 04:15:59,223 --> 04:16:01,458 DR. DANA FISCHER AND I WOULD 5272 04:16:01,458 --> 04:16:03,894 LIKE TO SEEK COUNCIL CLEARANCE 5273 04:16:03,894 --> 04:16:05,763 FOR INTEGRATION OF MEDICALLY 5274 04:16:05,763 --> 04:16:07,531 NECESSARY PREVENTION TREATMENT 5275 04:16:07,531 --> 04:16:09,433 AND MONITORING OF ONCOLOGIC 5276 04:16:09,433 --> 04:16:11,001 RELATED DENTAL, ORAL AND 5277 04:16:11,001 --> 04:16:17,074 CRANIOFACIAL COMPLICATIONS. 5278 04:16:17,074 --> 04:16:19,910 THE GOAL IS TO PROMOTE RESEARCH 5279 04:16:19,910 --> 04:16:23,380 TO REDUCE DENTAL, ORAL AND 5280 04:16:23,380 --> 04:16:25,349 CRANIOFACIAL COMPLICATIONS 5281 04:16:25,349 --> 04:16:26,684 DURING AND AFTER CANCER 5282 04:16:26,684 --> 04:16:29,720 TREATMENT OF ANY SITE. 5283 04:16:29,720 --> 04:16:32,790 THE INITIATIVE HAS THE MEDICAL 5284 04:16:32,790 --> 04:16:35,626 CARE AN ORAL CARE. 5285 04:16:35,626 --> 04:16:37,494 TRANSLATIONAL RESEARCH WITH 5286 04:16:37,494 --> 04:16:39,296 CLINICAL APPLICATIONS AND 5287 04:16:39,296 --> 04:16:41,432 RESEARCH THAT MAY EXTEND TO THE 5288 04:16:41,432 --> 04:16:42,032 COMMUNITY LEVEL TO RESPOND TO 5289 04:16:42,032 --> 04:16:52,276 THE INITIATIVE. 5290 04:16:52,276 --> 04:16:55,879 AND CHANGES IN MEDICARE POLICY 5291 04:16:55,879 --> 04:17:00,484 TO REDUCE COVERAGE GAP LINKED TO 5292 04:17:00,484 --> 04:17:07,458 THE MEDICAL ONCOLOGY SERVICES. 5293 04:17:07,458 --> 04:17:10,327 TO PROVIDE SOME BACKGROUND, 5294 04:17:10,327 --> 04:17:12,363 ABOUT 40% OR TWO OF FIVE 5295 04:17:12,363 --> 04:17:15,299 AMERICANS WILL BE DIAGNOSED WITH 5296 04:17:15,299 --> 04:17:18,602 CANCER ADENOCYTES IN THEIR LIFE 5297 04:17:18,602 --> 04:17:20,838 TIME AND MOST WILL LIVE FIVE 5298 04:17:20,838 --> 04:17:22,673 YEARS OR LONGER. 5299 04:17:22,673 --> 04:17:27,111 OVER THE DECADE THE NUMBER IS 5300 04:17:27,111 --> 04:17:29,380 EXPECTED TO INCREASE TO NEARLY 5301 04:17:29,380 --> 04:17:31,348 23 MILLION AMERICANS. 5302 04:17:31,348 --> 04:17:33,550 COMPLICATIONS FROM TREATMENTS 5303 04:17:33,550 --> 04:17:36,553 MAY INCLUDE SPREAD OF 5304 04:17:36,553 --> 04:17:39,323 INFECTIONS, CRANIOFACIAL GROWTH 5305 04:17:39,323 --> 04:17:45,863 AND DENTAL GROWTH AND 5306 04:17:45,863 --> 04:17:49,400 OSTEONECROSIS AND PAIN AND 5307 04:17:49,400 --> 04:17:53,504 POORER NUTRITION AND DYSPHAGIA 5308 04:17:53,504 --> 04:18:03,881 AND FIBROSIS AND MUCOSITEIS. 5309 04:18:03,881 --> 04:18:06,283 THEY CAN INTERFERE WITH CARE 5310 04:18:06,283 --> 04:18:08,185 LEADING TO REDUCED CANCER 5311 04:18:08,185 --> 04:18:11,889 TREATMENT AND INCREASED RISK 5312 04:18:11,889 --> 04:18:15,292 SUCH AS RISK OF COMPLICATIONS. 5313 04:18:15,292 --> 04:18:17,795 DEF 5314 04:18:20,697 --> 04:18:21,999 AND IT MAY REQUIRE ADDITIONAL 5315 04:18:21,999 --> 04:18:29,807 INTERVENTIONS. 5316 04:18:29,807 --> 04:18:32,543 AND THE RESULT IS INCREASED 5317 04:18:32,543 --> 04:18:33,544 HEALTH CARE COST AND PATIENT 5318 04:18:33,544 --> 04:18:42,319 BURDEN. 5319 04:18:42,319 --> 04:18:50,027 AND LEAD TO HEALTH INEQUITIES. 5320 04:18:50,027 --> 04:18:52,930 THUS THERE'S A NEED TO REDUCE 5321 04:18:52,930 --> 04:18:57,968 COMPLICATIONS FROM MANAGEMENT 5322 04:18:57,968 --> 04:19:07,044 AND INTEGRATE NECESSARY CARE AND 5323 04:19:07,044 --> 04:19:09,179 DENTAL SERVICES ARE LINKED TO 5324 04:19:09,179 --> 04:19:10,881 THE CLINICAL SUCCESS OF MEDICAL 5325 04:19:10,881 --> 04:19:12,516 ONCOLOGY OF SERVICES AND THERE'S 5326 04:19:12,516 --> 04:19:14,518 A CRITICAL NEED OF COORDINATED 5327 04:19:14,518 --> 04:19:17,521 MEDICAL AND DENTAL CARE FOR 5328 04:19:17,521 --> 04:19:18,055 ONCOLOGY PATIENTS. 5329 04:19:18,055 --> 04:19:20,491 THE INITIATIVE PROMOTES RESEARCH 5330 04:19:20,491 --> 04:19:26,763 TO BUILD NEW EVIDENCE ALONGSIDE 5331 04:19:26,763 --> 04:19:30,834 IMPLEMENTATION OF NEW CMS 5332 04:19:30,834 --> 04:19:32,002 POLICIES AND GAPS AND THE 5333 04:19:32,002 --> 04:19:35,906 INITIATIVE RESPONDS TO THE 2024 5334 04:19:35,906 --> 04:19:37,140 HHS APPROPRIATION BILL WHICH 5335 04:19:37,140 --> 04:19:38,342 STATES DENTAL CARE IS INTEGRAL 5336 04:19:38,342 --> 04:19:41,512 TO THE MEDICAL MANAGEMENT OF 5337 04:19:41,512 --> 04:19:42,980 NUMEROUS DISEASES AND MEDICAL 5338 04:19:42,980 --> 04:19:45,516 CONDITIONS AND THE LACK OF 5339 04:19:45,516 --> 04:19:47,484 MEDICALLY NECESSARY ORAL HEALTH 5340 04:19:47,484 --> 04:19:48,585 CARE HEIGHTENED THE RISK OF 5341 04:19:48,585 --> 04:19:50,854 MEDICAL COMPLICATIONS. 5342 04:19:50,854 --> 04:19:52,823 THE COMMITTEE URGES NIH TO FUND 5343 04:19:52,823 --> 04:19:54,658 ADDITIONAL RESEARCH IN THE AREA 5344 04:19:54,658 --> 04:19:56,093 AND CONDUCT TRIALS TO DETERMINE 5345 04:19:56,093 --> 04:19:57,794 WHICH ORAL CARE INTERVENTIONS 5346 04:19:57,794 --> 04:20:03,433 ARE MOST EFFECTIVE FOR IMPROVING 5347 04:20:03,433 --> 04:20:06,169 MANAGEMENT AND REDUCING 5348 04:20:06,169 --> 04:20:07,271 MALIGNANT CANCERS IN EMERGENCY 5349 04:20:07,271 --> 04:20:10,507 ROOM DEPARTMENT ADMISSION RATES. 5350 04:20:10,507 --> 04:20:14,144 THIS IS ALSO ADDRESSING ONE OF 5351 04:20:14,144 --> 04:20:16,680 THE NIDCR PRIORITIES AS 5352 04:20:16,680 --> 04:20:23,887 DR. WEBB-CYRIAQUE MENTIONED THIS 5353 04:20:23,887 --> 04:20:25,556 MORNING. 5354 04:20:25,556 --> 04:20:26,957 EXAMPLES OF RESEARCH STATUS IN 5355 04:20:26,957 --> 04:20:27,891 RESPONSE TO THE INITIATIVE 5356 04:20:27,891 --> 04:20:29,393 INCLUDE COORDINATED MEDICAL AND 5357 04:20:29,393 --> 04:20:31,895 DENTAL APPROACHES TO PREVENT, 5358 04:20:31,895 --> 04:20:38,969 REDUCE COMPLICATIONS OF HIGH 5359 04:20:38,969 --> 04:20:41,738 RISK PATIENTS AND PROPOSE 5360 04:20:41,738 --> 04:20:45,342 STUDIES OF POORLY UNDERSTOOD 5361 04:20:45,342 --> 04:20:50,180 COMPLICATIONS SUCH AS THOSE AS 5362 04:20:50,180 --> 04:20:51,615 NOVEL TREATMENTS AND METHODS TO 5363 04:20:51,615 --> 04:20:54,618 IMPROVE CLINICAL WORK FLOWS OR 5364 04:20:54,618 --> 04:20:56,320 REDUCE BARRIERS TO REDUCE 5365 04:20:56,320 --> 04:20:59,323 PREVENTIVE MEASURES AND REDUCE 5366 04:20:59,323 --> 04:20:59,656 COMPLICATIONS. 5367 04:20:59,656 --> 04:21:00,958 ANALYSIS OF ELECTRONIC HEALTH 5368 04:21:00,958 --> 04:21:03,126 RECORD OR INTEGRATED DENTAL CARE 5369 04:21:03,126 --> 04:21:05,262 AND DATA AND MECHANISTIC STUDIES 5370 04:21:05,262 --> 04:21:07,497 COULD BE INCLUDED TO SUPPORT AND 5371 04:21:07,497 --> 04:21:08,098 ENRICH THE PROPOSED CLINICAL 5372 04:21:08,098 --> 04:21:17,407 STUDY. 5373 04:21:17,407 --> 04:21:23,647 AND TO COUNCIL MEMBERS DR. NOR 5374 04:21:23,647 --> 04:21:33,090 AND MORON-KON SEPSIAN AGREED TO 5375 04:21:33,090 --> 04:21:34,324 REVIEW THIS. 5376 04:21:34,324 --> 04:21:37,094 >> THE CONCEPT THAT WAS BROUGHT 5377 04:21:37,094 --> 04:21:39,363 FORWARD BY YOURSELF AND 5378 04:21:39,363 --> 04:21:43,900 DR. FISCHER IS TIMELY AND HIGHLY 5379 04:21:43,900 --> 04:21:53,677 IMPACTFUL. 5380 04:21:53,677 --> 04:21:58,715 AND RADIATION IN THE HEAD AND 5381 04:21:58,715 --> 04:22:03,353 NECK AREAS CAN LEAD TO CARIES 5382 04:22:03,353 --> 04:22:03,954 AND PERIODONTAL DISEASE AND 5383 04:22:03,954 --> 04:22:07,157 THERE'S MANY THERAPIES THAT CAN 5384 04:22:07,157 --> 04:22:09,359 CAUSE THIS IN THE PATIENTS. 5385 04:22:09,359 --> 04:22:12,529 RADIATION CAN INCREASE THE 5386 04:22:12,529 --> 04:22:15,832 CHANCE OF OSTEONECROSIS WHICH 5387 04:22:15,832 --> 04:22:18,435 CAN BE DEBILITATING UP TO FIVE 5388 04:22:18,435 --> 04:22:19,903 YEARS AFTER RADIATION. 5389 04:22:19,903 --> 04:22:22,339 WITH IMPROVEMENTS IN CANCER 5390 04:22:22,339 --> 04:22:23,874 TREATMENT THERE'S AN INCREASE IN 5391 04:22:23,874 --> 04:22:27,344 LIFE EXPECTANCY AND THEREFORE 5392 04:22:27,344 --> 04:22:33,183 THE MANAGEMENT OF DENTAL, ORAL 5393 04:22:33,183 --> 04:22:36,687 AND CRANIOFACIAL COMPLICATIONS 5394 04:22:36,687 --> 04:22:46,563 IS IMPACT AND POTENTIAL TO 5395 04:22:46,563 --> 04:22:47,898 PREVENT COMPLICATIONS AND MAY 5396 04:22:47,898 --> 04:22:49,800 LEAD TO NEW EVERYDAY THAT 5397 04:22:49,800 --> 04:22:51,902 DEMONSTRATE THE CRITICAL 5398 04:22:51,902 --> 04:22:54,204 IMPORTANCE OF INSURANCE FOR 5399 04:22:54,204 --> 04:22:56,139 DENTAL PROCEDURES TO THE OUTCOME 5400 04:22:56,139 --> 04:22:58,942 AND QUALITY OF LIFE OF PATIENTS 5401 04:22:58,942 --> 04:22:59,876 WITH CANCER. 5402 04:22:59,876 --> 04:23:03,146 I THINK YOU DID A WONDERFUL JOB 5403 04:23:03,146 --> 04:23:04,681 PUTTING THE CONCEPT TOGETHER AS 5404 04:23:04,681 --> 04:23:07,884 I SAID IS EXTREMELY SIGNIFICANT 5405 04:23:07,884 --> 04:23:17,994 TO ME. 5406 04:23:22,065 --> 04:23:23,900 I HAVE A COUPLE RECOMMENDATION 5407 04:23:23,900 --> 04:23:27,637 TO FOSTER DEVELOPMENT AND 5408 04:23:27,637 --> 04:23:30,240 EVALUATION OF THE EFFECTIVENESS 5409 04:23:30,240 --> 04:23:31,541 OF EDUCATIONAL PROGRAMS FOR 5410 04:23:31,541 --> 04:23:33,009 POST-CANCER TREATMENT PATIENTS 5411 04:23:33,009 --> 04:23:34,745 OF THE IMPORTANCE OF GOOD ORAL 5412 04:23:34,745 --> 04:23:37,214 HEALTH. 5413 04:23:37,214 --> 04:23:38,515 THIS IS ESPECIALLY SIGNIFICANT 5414 04:23:38,515 --> 04:23:43,487 BECAUSE PATIENTS HAVE MANY OTHER 5415 04:23:43,487 --> 04:23:54,030 WORE RID -- WORRIES AND ARE ORAL 5416 04:23:54,264 --> 04:23:58,468 HYGIENE MY IMPACT OVER ALL 5417 04:23:58,468 --> 04:23:59,736 QUALITY OF LIFE AND NUTRITION 5418 04:23:59,736 --> 04:24:01,772 FOR PATIENTS AND IT'S IMPORTANT 5419 04:24:01,772 --> 04:24:03,840 TO REMEMBER MANY PATIENTS COULD 5420 04:24:03,840 --> 04:24:05,408 BE MORE SUSCEPTIBLE TO 5421 04:24:05,408 --> 04:24:08,145 INFECTIONS DUE TO ANTI-CANCER 5422 04:24:08,145 --> 04:24:11,014 THERAPIES TO THE IMMUNE SYSTEM. 5423 04:24:11,014 --> 04:24:15,886 ANOTHER REASON WHERE PROGRAMS TO 5424 04:24:15,886 --> 04:24:18,455 STIMULATE AND INFORM ABOUT ORAL 5425 04:24:18,455 --> 04:24:21,358 HEALTH BECOME IMPORTANT. 5426 04:24:21,358 --> 04:24:23,093 MY OTHER SUGGESTION IS MINOR IS 5427 04:24:23,093 --> 04:24:26,596 TO AN EXISTING AREA OF INTEREST 5428 04:24:26,596 --> 04:24:31,902 AND THE FIFTH LISTED IN YOUR 5429 04:24:31,902 --> 04:24:35,872 LIST THE FIRST IN THE SECOND 5430 04:24:35,872 --> 04:24:39,543 SLIDE TO ADD RADIATION THERAPY 5431 04:24:39,543 --> 04:24:42,245 AND CONTROLLED RESEARCH STUDIES 5432 04:24:42,245 --> 04:24:45,115 TO TEST EFFECTIVENESS OF 5433 04:24:45,115 --> 04:24:47,818 DIFFERENT DENTAL CARE PROTOCOLS 5434 04:24:47,818 --> 04:24:49,586 PRIOR TO OR DURING CHEMOTHERAPY 5435 04:24:49,586 --> 04:24:52,656 OR RADIATION THERAPY TO IMPROVE 5436 04:24:52,656 --> 04:24:55,292 CLINICAL GUIDELINES. 5437 04:24:55,292 --> 04:25:01,031 I SAY THAT BECAUSE DEPENDING ON 5438 04:25:01,031 --> 04:25:05,168 THE TYPE OF TREATMENT OR CHEMO 5439 04:25:05,168 --> 04:25:09,639 OR A COMBINATION BUT BOTH HAVE 5440 04:25:09,639 --> 04:25:11,074 SIGNIFICANT IMPACTS ON ORAL 5441 04:25:11,074 --> 04:25:11,875 HEALTH. 5442 04:25:11,875 --> 04:25:12,976 THE POTENTIAL IMPACT AND 5443 04:25:12,976 --> 04:25:14,311 SIGNIFICANCE OF RESEARCH 5444 04:25:14,311 --> 04:25:16,947 STIMULATED BY THE CONCEPT ARE 5445 04:25:16,947 --> 04:25:19,382 TRULY EXCEPTIONAL. 5446 04:25:19,382 --> 04:25:21,918 THE CONCEPT IS TIMELY AS IT 5447 04:25:21,918 --> 04:25:23,453 ADDRESSES THE INCREASED NEED FOR 5448 04:25:23,453 --> 04:25:25,422 ORAL AND DENTAL CARE OF PATIENTS 5449 04:25:25,422 --> 04:25:32,229 WHO EN ABOUT -- WHO BENEFITTED 5450 04:25:32,229 --> 04:25:35,198 POST THERAPY AND I SUPPORT THE 5451 04:25:35,198 --> 04:25:35,899 CONCEPT WITHOUT ANY HESITATION. 5452 04:25:35,899 --> 04:25:46,076 THANK YOU. 5453 04:25:46,810 --> 04:25:50,680 >> I AGREE IT'S A TIMELY CONCEPT 5454 04:25:50,680 --> 04:25:52,415 AND HASN'T BEEN INVESTIGATED OR 5455 04:25:52,415 --> 04:25:54,184 EXPLORED IN THE PAST. 5456 04:25:54,184 --> 04:25:56,853 IT'S IMPORTANT AND I APPRECIATE 5457 04:25:56,853 --> 04:25:58,255 YOUR EFFORTS ON PUTTING 5458 04:25:58,255 --> 04:25:58,521 TOGETHER. 5459 04:25:58,521 --> 04:26:02,392 I HAVE A FEW COMMENTS AND 5460 04:26:02,392 --> 04:26:03,093 SUGGESTIONS. 5461 04:26:03,093 --> 04:26:06,963 THE FIRST ONE IS AS A BASIC 5462 04:26:06,963 --> 04:26:12,068 SCIENTIST I APPRECIATE WHEN WE 5463 04:26:12,068 --> 04:26:14,070 DEFINE A CONCEPT AND TALKING 5464 04:26:14,070 --> 04:26:15,205 ABOUT TRANSLATIONAL AND 5465 04:26:15,205 --> 04:26:15,472 CLINICAL. 5466 04:26:15,472 --> 04:26:17,641 I THINK IT WOULD BE GOOD TO 5467 04:26:17,641 --> 04:26:21,978 EMPHASIZE THIS IS GOING TO BE 5468 04:26:21,978 --> 04:26:23,380 SUPPORTING BASIC RESEARCH THAT 5469 04:26:23,380 --> 04:26:26,182 CAN PROVIDE NEW MECHANISTIC 5470 04:26:26,182 --> 04:26:27,350 INSIGHTS HOW TO IMPROVE DENTAL 5471 04:26:27,350 --> 04:26:32,989 TREATMENT. 5472 04:26:32,989 --> 04:26:39,863 AND WHEN WE SAY TRANSLATIONAL IT 5473 04:26:39,863 --> 04:26:41,932 CAN BE CLINICAL OR BASIC BUT 5474 04:26:41,932 --> 04:26:43,900 BASIC SHOULD BE INCORPORATED 5475 04:26:43,900 --> 04:26:45,335 HERE. 5476 04:26:45,335 --> 04:26:51,374 THE OTHER THING I THINK THAT'S 5477 04:26:51,374 --> 04:26:56,746 IMPORTANT WHERE YOU DESCRIBE 5478 04:26:56,746 --> 04:26:58,581 INTERESTS IS COMORBIDITY. 5479 04:26:58,581 --> 04:27:01,251 AND ONE OF THE IMPORTANT 5480 04:27:01,251 --> 04:27:03,286 COMORBIDITIES IS PAIN 5481 04:27:03,286 --> 04:27:03,586 MANAGEMENT. 5482 04:27:03,586 --> 04:27:07,424 MANY TIMES THE CANCER SURVIVORS 5483 04:27:07,424 --> 04:27:09,259 HAVE BEEN EXPOSED TO TREATMENT 5484 04:27:09,259 --> 04:27:12,896 AND SOME HAVE BEEN TAKEN OPIOIDS 5485 04:27:12,896 --> 04:27:14,631 AND BECAUSE OF CHRONIC OPIOID 5486 04:27:14,631 --> 04:27:19,903 TREATMENT CAN LEAD TO ANALGESIA 5487 04:27:19,903 --> 04:27:27,277 AND TOLERANCE AND INCORPORATED 5488 04:27:27,277 --> 04:27:30,380 AS A GOAL HOW YOU MANAGE PAIN 5489 04:27:30,380 --> 04:27:33,583 DURING COMPLICATIONS AFTER DOC 5490 04:27:33,583 --> 04:27:35,885 DEPENDING ON HOW THE HISTORY OF 5491 04:27:35,885 --> 04:27:39,889 THE PATIENT AND AGAIN THAT COULD 5492 04:27:39,889 --> 04:27:43,893 BE A PILOT WIN CLINICAL AND 5493 04:27:43,893 --> 04:27:46,062 BASIC RESEARCH. 5494 04:27:46,062 --> 04:27:47,897 THE OTHER COMORBIDITY THAT 5495 04:27:47,897 --> 04:27:50,467 SHOULD BE INCLUDED IS SOMETIMES 5496 04:27:50,467 --> 04:27:54,971 BECAUSE OF THE TREATMENT THESE 5497 04:27:54,971 --> 04:28:05,515 PATIENTS ARE TREATED SHOULD BE 5498 04:28:12,389 --> 04:28:13,890 STUDIED AND WHAT I'LL MENTION 5499 04:28:13,890 --> 04:28:17,127 ABOUT CONTROL AND STUDIES TO 5500 04:28:17,127 --> 04:28:21,664 TEST THE DIFFERENT PROTOCOLS 5501 04:28:21,664 --> 04:28:22,899 DURING OR PRIOR OR AFTER CHEMO 5502 04:28:22,899 --> 04:28:26,269 OR RADIO THERAPY. 5503 04:28:26,269 --> 04:28:29,639 IT SHOULD BE DONE WITH BASIC 5504 04:28:29,639 --> 04:28:35,879 STUDIES YOU CAN DO THIS WITH 5505 04:28:35,879 --> 04:28:40,650 DIFFERENT MODELS AND WOULD BE 5506 04:28:40,650 --> 04:28:42,485 GOOD TO UNDERSTAND THE BEST TIME 5507 04:28:42,485 --> 04:28:49,192 TO PROVIDE THAT TREATMENT. 5508 04:28:49,192 --> 04:28:50,693 ONE FINAL COMMENT I HAVE THAT IS 5509 04:28:50,693 --> 04:28:54,697 BIG PICTURE, I UNDERSTAND IT'S 5510 04:28:54,697 --> 04:28:57,567 SUPPORTED BY ONLY NIDCR. 5511 04:28:57,567 --> 04:29:00,336 IS THERE ANY REASON WHY NCI 5512 04:29:00,336 --> 04:29:05,975 CAN'T BE INVOLVED IN THIS? 5513 04:29:05,975 --> 04:29:08,078 YOU CAN HAVE RFAs BY TWO 5514 04:29:08,078 --> 04:29:09,946 INSTITUTES OR MORE AND MAY BE 5515 04:29:09,946 --> 04:29:14,117 ABLE TO BRING PEOPLE NOT IN THE 5516 04:29:14,117 --> 04:29:17,887 DENTAL FIELD AND WORKING IN 5517 04:29:17,887 --> 04:29:23,193 BIOLOGY AND COULD PROVIDE A 5518 04:29:23,193 --> 04:29:23,860 DIFFERENT POINT OF VIEW AND 5519 04:29:23,860 --> 04:29:25,028 EXPAND RESEARCH BUT IT'S MY LAST 5520 04:29:25,028 --> 04:29:27,363 POINT. 5521 04:29:27,363 --> 04:29:28,164 THANK YOU VERY MUCH. 5522 04:29:28,164 --> 04:29:34,237 >> THANK YOU, MORON-CONCEPCION 5523 04:29:34,237 --> 04:29:45,081 WE'RE PENDING THE APOSCONTACT W 5524 04:29:46,583 --> 04:29:47,016 NCI. 5525 04:29:47,016 --> 04:29:50,053 >> IT'S GREAT WHEN WE CAN BRING 5526 04:29:50,053 --> 04:29:52,021 IN A DIFFERENT PERSPECTIVE AND 5527 04:29:52,021 --> 04:29:54,824 THAT'S THE WAY TO FIND NEW 5528 04:29:54,824 --> 04:29:56,259 APPROACHES OF THERAPEUTIC 5529 04:29:56,259 --> 04:29:56,493 TARGETS. 5530 04:29:56,493 --> 04:29:57,360 THAT SOUNDS GOOD. 5531 04:29:57,360 --> 04:30:02,332 >> THANK YOU. 5532 04:30:02,332 --> 04:30:12,842 >> IS THERE ANY OTHER COMMENT? 5533 04:30:13,042 --> 04:30:16,513 IF NOT WOULD A MEMBER OF COUNCIL 5534 04:30:16,513 --> 04:30:18,214 LIKE TO MAKE I MOTION. 5535 04:30:18,214 --> 04:30:19,883 >> WOULD ANYONE LIKE TO SECOND. 5536 04:30:19,883 --> 04:30:21,851 >> SECOND, PAUL. 5537 04:30:21,851 --> 04:30:23,887 >> THANK YOU. 5538 04:30:23,887 --> 04:30:31,327 ALL IN FAVOR? 5539 04:30:31,327 --> 04:30:31,594 THANK YOU. 5540 04:30:31,594 --> 04:30:38,801 ANY OPPOSED? 5541 04:30:38,801 --> 04:30:39,702 THE NEXT CONCEPT ARE WE READY TO 5542 04:30:39,702 --> 04:30:47,010 MOVE ON? 5543 04:30:47,010 --> 04:30:55,084 WILL BE PRESENTED BY DR. IDA. 5544 04:30:55,084 --> 04:30:56,719 >> GOOD AFTERNOON. 5545 04:30:56,719 --> 04:31:02,625 UME THE DIRECTOR OF ORAL HEALTH 5546 04:31:02,625 --> 04:31:04,527 DISPARITIES AND INEQUITIES 5547 04:31:04,527 --> 04:31:06,229 PROGRAM IN THE DIVISION OF 5548 04:31:06,229 --> 04:31:07,030 EXTRAMURAL RESEARCH. 5549 04:31:07,030 --> 04:31:10,033 THE CONCEPT PROPOSAL I'M 5550 04:31:10,033 --> 04:31:11,234 PRESENTING FOR COUNCIL 5551 04:31:11,234 --> 04:31:13,836 CONCURRENCE IS COMMUNITY ENGAGED 5552 04:31:13,836 --> 04:31:15,872 RESEARCH TO ADVANCE ORAL HEALTH 5553 04:31:15,872 --> 04:31:18,374 INTERVENTION MODELS FOR 5554 04:31:18,374 --> 04:31:19,876 RACIAL/ETHNIC MINORITY HIV/AIDS 5555 04:31:19,876 --> 04:31:30,086 POPULATIONS. 5556 04:31:32,055 --> 04:31:35,658 THE GOAL IS TO SUPPORT 5557 04:31:35,658 --> 04:31:36,492 EFFECTIVENESS AND EQUITY OF 5558 04:31:36,492 --> 04:31:38,494 HIV/AIDS AND ORAL HEALTH 5559 04:31:38,494 --> 04:31:39,495 INTERVENTION MODEL FOR RACIAL 5560 04:31:39,495 --> 04:31:41,764 AND ETHNIC MINORITIES LIVING 5561 04:31:41,764 --> 04:31:44,133 WITH HIV/AIDS OR AT RISK FOR 5562 04:31:44,133 --> 04:31:44,701 ACQUIRING HIV IN THE UNITED 5563 04:31:44,701 --> 04:31:51,874 STATES. 5564 04:31:51,874 --> 04:31:54,377 AND WHILE NEW INFECTIONS HAVE 5565 04:31:54,377 --> 04:31:58,348 DECREASED IN RECENT YEARS, 5566 04:31:58,348 --> 04:32:01,084 NON-HISPANIC BLACK AND LATINO 5567 04:32:01,084 --> 04:32:02,285 PEOPLE ARE DISPROPORTIONATELY 5568 04:32:02,285 --> 04:32:06,122 AFFECTED BY HIV AS SHOWN IN THE 5569 04:32:06,122 --> 04:32:07,890 FIGURE SHOWING THE DISTRIBUTION 5570 04:32:07,890 --> 04:32:11,027 IN U.S. POPULATION BY RACE AND 5571 04:32:11,027 --> 04:32:13,129 ETHNICITY ON THE RIGHT AND HIV 5572 04:32:13,129 --> 04:32:14,864 INCIDENTS BY RACE AND ETHNICITY 5573 04:32:14,864 --> 04:32:19,869 ON THE LEFT. 5574 04:32:19,869 --> 04:32:25,008 SO NON-HISPANIC BLACK PEOPLE 5575 04:32:25,008 --> 04:32:27,810 ACCOUNTS FOR NEW HIV INFECTIONS 5576 04:32:27,810 --> 04:32:29,579 AND AMONG BLACK WOMEN WAS TEN 5577 04:32:29,579 --> 04:32:31,881 TIMES THAT OF NON-HISPANIC WHITE 5578 04:32:31,881 --> 04:32:33,850 WOMEN AND FOUR TIMES THAT OF 5579 04:32:33,850 --> 04:32:42,458 LATINO WOMEN IN 2021. 5580 04:32:42,458 --> 04:32:45,361 AMERICAN INDIAN AND ALASKAN 5581 04:32:45,361 --> 04:32:47,230 NATIVE PEOPLE REPRESENT A LOW 5582 04:32:47,230 --> 04:32:49,766 NUMBER BUT THE RATE OF NEW 5583 04:32:49,766 --> 04:32:51,367 DIAGNOSIS IS TWICE HIGHER OF 5584 04:32:51,367 --> 04:33:01,811 NON-HISPANIC WHITE PEOPLE. 5585 04:33:04,380 --> 04:33:07,250 CDC DATA USING THE CONTINUUM OF 5586 04:33:07,250 --> 04:33:10,787 HIV CARE FRAMEWORK INDICATE 87% 5587 04:33:10,787 --> 04:33:12,989 OF 1.2 MILLION PEOPLE ESTIMATED 5588 04:33:12,989 --> 04:33:15,491 TO LIVE WITH HIV IN THE UNITED 5589 04:33:15,491 --> 04:33:19,028 STATES IN 2022 WERE LIVING WITH 5590 04:33:19,028 --> 04:33:19,862 DIAGNOSED HIV. 5591 04:33:19,862 --> 04:33:21,531 THEY KNOW THE DIAGNOSIS. 5592 04:33:21,531 --> 04:33:26,536 AND 66% OF THEM WITH DIAGNOSED 5593 04:33:26,536 --> 04:33:33,343 HIV HAD AT LEAST ONE CD4 VIRAL 5594 04:33:33,343 --> 04:33:36,179 LOAD CARE AND 47% WERE RETAINED 5595 04:33:36,179 --> 04:33:39,349 IN CARE BY HAVING TWO OR MORE 5596 04:33:39,349 --> 04:33:43,319 VIRAL LOAD TEST RESULTS OF AT 5597 04:33:43,319 --> 04:33:53,396 LEAST THREE MONTHS APART AND 57% 5598 04:33:53,396 --> 04:33:56,065 HAD A VIRAL SUPPRESSION AND BY 5599 04:33:56,065 --> 04:33:57,667 LOOKING AT THE HIV CARE 5600 04:33:57,667 --> 04:34:00,403 CONTINUUM CARE DATA BY RACE AND 5601 04:34:00,403 --> 04:34:01,838 ETHNICITY THE HIV CARE RECEIVED 5602 04:34:01,838 --> 04:34:06,175 AND VIRAL SUPPRESSION WERE THE 5603 04:34:06,175 --> 04:34:09,946 LOWEST AMONG AMERICAN INDIAN AND 5604 04:34:09,946 --> 04:34:11,881 ALASKAN NATIVE PEOPLE AND THE 5605 04:34:11,881 --> 04:34:13,416 PREVALENCE OF RETENTION IN HIV 5606 04:34:13,416 --> 04:34:19,856 CARE WAS THE LOWEST AMONG NATIVE 5607 04:34:19,856 --> 04:34:22,558 HAWAIIANS AND MEN WHO HAVE SEX 5608 04:34:22,558 --> 04:34:26,863 WITH MEN WITH DIAGNOSED HIV 5609 04:34:26,863 --> 04:34:28,664 FEWER HISPANIC LATINO MEN AND 5610 04:34:28,664 --> 04:34:30,533 NATIVE HAWAIIAN OR OTHER PACIFIC 5611 04:34:30,533 --> 04:34:34,404 ISLANDER MEN RECEIVED HIV 5612 04:34:34,404 --> 04:34:42,445 MEDICAL CARE THAN OVER ALL MSM 5613 04:34:42,445 --> 04:34:45,848 POPULATION AND BLACK MEN HAVE 5614 04:34:45,848 --> 04:34:46,649 THE LOWEST IN THE MOST RECENT 5615 04:34:46,649 --> 04:34:51,888 LABORATORY TESTS. 5616 04:34:51,888 --> 04:34:56,459 SO THESE NATIONAL DATA INDICATE 5617 04:34:56,459 --> 04:34:58,661 THAT HIV DIAGNOSIS AND ACCESS 5618 04:34:58,661 --> 04:35:01,464 AND OUTCOME OF HIV CARE MAY BE 5619 04:35:01,464 --> 04:35:04,600 AFFECTED BY THE COMPLEX 5620 04:35:04,600 --> 04:35:06,602 INTERACTION BETWEEN INDIVIDUAL 5621 04:35:06,602 --> 04:35:09,372 RACE, ETHNICITY, OTHER SOCIAL 5622 04:35:09,372 --> 04:35:11,774 IDENTITIES AND SYSTEMS OF 5623 04:35:11,774 --> 04:35:12,308 INEQUALITY. 5624 04:35:12,308 --> 04:35:13,709 THERE'S SUBSTANTIAL DISPARITIES 5625 04:35:13,709 --> 04:35:15,878 IN DENTAL CARE ACCESS AND 5626 04:35:15,878 --> 04:35:17,013 OUTCOME BY RACE AND ETHNICITY AS 5627 04:35:17,013 --> 04:35:20,883 WELL AS WE ALL KNOW. 5628 04:35:20,883 --> 04:35:23,219 IT BEEN REPORTED UNMET DENTAL 5629 04:35:23,219 --> 04:35:27,390 CARE NEEDS ARE MORE THAN TWICE 5630 04:35:27,390 --> 04:35:28,458 PREVALENT AMONG PEOPLE LIVING 5631 04:35:28,458 --> 04:35:29,425 WITH HIV/AIDS. 5632 04:35:29,425 --> 04:35:32,395 AND THIS COULD BE BECAUSE OF THE 5633 04:35:32,395 --> 04:35:34,730 HEIGHTENED NEEDS AND RISK FOR 5634 04:35:34,730 --> 04:35:35,865 ORAL HEALTH PROBLEMS AMONG 5635 04:35:35,865 --> 04:35:38,201 PEOPLE LIVING WITH HIV OR AT 5636 04:35:38,201 --> 04:35:42,972 RISK OF ACQUIRING HIV. 5637 04:35:42,972 --> 04:35:43,906 COMPOUNDED BY HIV/AIDS RELATED 5638 04:35:43,906 --> 04:35:47,376 AND UNRELATED BARE YEARS TO 5639 04:35:47,376 --> 04:35:48,311 DENTAL CARE INCLUDING SOCIAL 5640 04:35:48,311 --> 04:35:51,647 DETERMINATES OF HEALTH, STIGMA, 5641 04:35:51,647 --> 04:35:52,048 BIAS, RACISM AND 5642 04:35:52,048 --> 04:36:02,325 DISCRIMINATIONS. 5643 04:36:10,266 --> 04:36:11,367 THIS RESPONDS TO THE INEQUITIES 5644 04:36:11,367 --> 04:36:13,769 IN THE BUDGET AND ALIGNS WITH 5645 04:36:13,769 --> 04:36:17,206 ORAL HEALTH DISPARITIES 5646 04:36:17,206 --> 04:36:19,909 INEQUITIES RESEARCH PROGRAM 5647 04:36:19,909 --> 04:36:21,210 FUTURE INITIATIVE ADAPTED AS 5648 04:36:21,210 --> 04:36:23,813 MENTIONED EARLIER TODAY. 5649 04:36:23,813 --> 04:36:25,581 THE POPULATION COMMUNITY OF 5650 04:36:25,581 --> 04:36:27,250 INTEREST FOR THIS INITIATIVE IS 5651 04:36:27,250 --> 04:36:28,784 RACIAL AND ETHNIC MINORITIES 5652 04:36:28,784 --> 04:36:31,921 LIVING WITH OR AT RISK OF HIV 5653 04:36:31,921 --> 04:36:34,590 AND THE POTENTIAL APPLICANTS 5654 04:36:34,590 --> 04:36:38,060 SHOULD PROPOSE STRATEGIES FOR 5655 04:36:38,060 --> 04:36:39,095 EQUITABLE PARTNERSHIPS AND 5656 04:36:39,095 --> 04:36:41,230 EXISTING COMMUNITY ENGAGEMENT TO 5657 04:36:41,230 --> 04:36:44,967 DETERMINE THE CAPACITY OF 5658 04:36:44,967 --> 04:36:46,802 MEANINGFUL CO-LEARNING WITH THE 5659 04:36:46,802 --> 04:36:49,071 TARGET COMMUNITY ON THE OPTIMAL 5660 04:36:49,071 --> 04:36:50,473 MODEL OF ORAL HEALTH AND HIV 5661 04:36:50,473 --> 04:36:51,173 CARE DELIVERY. 5662 04:36:51,173 --> 04:36:51,908 IN ADDITION TO SCIENTIFIC 5663 04:36:51,908 --> 04:37:02,084 PROPOSAL. 5664 04:37:03,019 --> 04:37:04,921 SO THE EXAMPLES OF AREAS OF THE 5665 04:37:04,921 --> 04:37:07,390 INITIATIVE INCLUDE BUT NOT 5666 04:37:07,390 --> 04:37:09,559 LIMITED TO STUDIES TO UNDERSTAND 5667 04:37:09,559 --> 04:37:12,595 MULTI-LEVEL BARRIERS AND 5668 04:37:12,595 --> 04:37:13,362 FACILITATORS FOR HIV/AIDS AND 5669 04:37:13,362 --> 04:37:15,932 ORAL HEALTH INTERVENTIONS BY 5670 04:37:15,932 --> 04:37:19,936 PAYING ATTENTION TO 5671 04:37:19,936 --> 04:37:21,237 INTERSECTIONALITY OR TEST 5672 04:37:21,237 --> 04:37:23,205 ACCEPTABILITY AND EFFECTIVENESS 5673 04:37:23,205 --> 04:37:24,540 OF NON-TRADITIONAL POINT OF 5674 04:37:24,540 --> 04:37:27,910 ENTRY FOR INTERVENTIONS RELATED 5675 04:37:27,910 --> 04:37:29,912 TO HIV/AIDS IN ORAL HEALTH 5676 04:37:29,912 --> 04:37:31,914 SCREENING AND COORDINATION OF 5677 04:37:31,914 --> 04:37:34,784 KNOWLEDGE AND SERVICES. 5678 04:37:34,784 --> 04:37:37,119 OR ADDRESS STRUCTURAL RACISM AND 5679 04:37:37,119 --> 04:37:38,788 SOCIAL DETERMINATES OF HEALTH 5680 04:37:38,788 --> 04:37:39,755 EFFECTS HIV/AIDS AND ORAL HEALTH 5681 04:37:39,755 --> 04:37:44,961 CARE ACCESS AND OUTCOMES AND 5682 04:37:44,961 --> 04:37:47,930 ASSESS COMMUNICATION AND 5683 04:37:47,930 --> 04:37:50,900 ENGAGEMENT STRATEGIES FOR 5684 04:37:50,900 --> 04:37:52,568 EQUITABLE UPTAKE OF 5685 04:37:52,568 --> 04:37:53,903 EVIDENCE-BASED INTERVENTION AND 5686 04:37:53,903 --> 04:38:00,042 SUSTAINABLE PRE VENTION FOR ORAL 5687 04:38:00,042 --> 04:38:05,348 AND DENTAL DISEASES OR ASSESS 5688 04:38:05,348 --> 04:38:07,917 THE SUPPORT INTEGRATION IN THE 5689 04:38:07,917 --> 04:38:15,825 PROGRAM SITES. 5690 04:38:15,825 --> 04:38:19,895 THANK YOU AND TWO REVIEWERS FOR 5691 04:38:19,895 --> 04:38:23,232 THE INITIATIVES ARE 5692 04:38:23,232 --> 04:38:29,105 DR. KREBSBACH AND DR. DICKINSON. 5693 04:38:29,105 --> 04:38:29,772 THANK YOU. 5694 04:38:29,772 --> 04:38:32,008 I LOOK FORWARD TO YOUR COMMENTS. 5695 04:38:32,008 --> 04:38:33,175 >> THANK YOU FOR PUTTING THAT 5696 04:38:33,175 --> 04:38:33,442 TOGETHER. 5697 04:38:33,442 --> 04:38:36,746 I THOUGHT IT WAS A VERY 5698 04:38:36,746 --> 04:38:37,947 DIFFICULT SOCIAL PROBLEM TO 5699 04:38:37,947 --> 04:38:41,150 ADDRESS AND I THINK YOU DID A 5700 04:38:41,150 --> 04:38:47,556 REALLY GREAT JOB AND THINK IT'S 5701 04:38:47,556 --> 04:38:51,427 EXTRAORDINARILY IMPORTANT. 5702 04:38:51,427 --> 04:38:53,529 THERE ARE SIGNIFICANT DATA 5703 04:38:53,529 --> 04:38:54,530 DISPARITIES WITH HIV/AIDS AND 5704 04:38:54,530 --> 04:38:56,899 ORAL HEALTH AMONG THESE RACIAL 5705 04:38:56,899 --> 04:38:57,867 AND ETHNIC MINORITIES. 5706 04:38:57,867 --> 04:39:00,670 I THINK IT'S REALLY IMPORTANT TO 5707 04:39:00,670 --> 04:39:06,542 WORK ON THE UNDER SERVED 5708 04:39:06,542 --> 04:39:06,842 POPULATIONS. 5709 04:39:06,842 --> 04:39:08,411 I THOUGHT IT WAS A COMPREHENSIVE 5710 04:39:08,411 --> 04:39:09,545 APPROACH WITH THE 5711 04:39:09,545 --> 04:39:10,246 COMMUNITY-ENGAGED RESEARCH. 5712 04:39:10,246 --> 04:39:13,916 IT'S IMPORTANT THAT WE PARTNER 5713 04:39:13,916 --> 04:39:17,019 WITH THE AFFECTED COMMUNITIES 5714 04:39:17,019 --> 04:39:17,987 TOO. 5715 04:39:17,987 --> 04:39:19,822 THEY DO HAVE CERTAIN STRUCTURAL 5716 04:39:19,822 --> 04:39:22,525 BARRIERS LIKE STIGMA AND RACISM 5717 04:39:22,525 --> 04:39:26,228 AND OTHER HEALTH INEQUITIES THAT 5718 04:39:26,228 --> 04:39:28,431 MAKES IT EVEN MORE COMPLEX FOR 5719 04:39:28,431 --> 04:39:28,764 THEM. 5720 04:39:28,764 --> 04:39:32,735 I LIKE THE ORAL SYSTEMIC 5721 04:39:32,735 --> 04:39:33,035 CONNECTION. 5722 04:39:33,035 --> 04:39:35,938 I THINK IN DENTISTRY WE'RE 5723 04:39:35,938 --> 04:39:38,374 TAKING A STRONG LOOK AT THAT AND 5724 04:39:38,374 --> 04:39:43,245 THIS CONTINUES THAT AND THIS 5725 04:39:43,245 --> 04:39:44,280 CONCEPT MOVING FORWARD WE 5726 04:39:44,280 --> 04:39:47,917 PROVIDE THAT HOLISTIC APPROACH 5727 04:39:47,917 --> 04:39:50,019 TO MANAGING THE CHRONIC DISEASES 5728 04:39:50,019 --> 04:39:57,860 WHEN YOU HAVE OTHER COMORBI 5729 04:39:57,860 --> 04:40:00,830 COMORBIDITIES AND IMPORTANT TO 5730 04:40:00,830 --> 04:40:01,664 THE SOCIAL DETERMINATES OF 5731 04:40:01,664 --> 04:40:01,931 HEALTH. 5732 04:40:01,931 --> 04:40:04,800 YOU PROBABLY DON'T WANT TO BE 5733 04:40:04,800 --> 04:40:06,068 REDUNDANT BUT I THOUGHT IT 5734 04:40:06,068 --> 04:40:07,903 SHOULD HAVE BEEN UP ON THE FIRST 5735 04:40:07,903 --> 04:40:11,340 PAGE THERE WHEN YOU TALKED ABOUT 5736 04:40:11,340 --> 04:40:14,610 RACISM AND ETHNICITY TOO. 5737 04:40:14,610 --> 04:40:15,778 THE SOCIAL DETERMINATES OF 5738 04:40:15,778 --> 04:40:16,946 HEALTH MAY BE MORE IMPORTANT 5739 04:40:16,946 --> 04:40:27,423 THAN JUST THE ETHNICITY OR 5740 04:40:31,961 --> 04:40:35,397 PROFILE AND YOU DID ADDRESS THAT 5741 04:40:35,397 --> 04:40:38,167 LATER ON IN THE SECOND PAGE OF 5742 04:40:38,167 --> 04:40:39,935 THE CONCEPT CLEARANCE. 5743 04:40:39,935 --> 04:40:44,540 I LIKE THE PARTNERSHIP WITH THE 5744 04:40:44,540 --> 04:40:45,741 LARGER COMMUNITY-BASED 5745 04:40:45,741 --> 04:40:50,780 ORGANIZATIONS LIKE THE RYAN 5746 04:40:50,780 --> 04:40:55,084 WHITE PROGRAM AND URBAN SETTINGS 5747 04:40:55,084 --> 04:40:56,752 HAVE HOSPITALS THAT TAKE THESE 5748 04:40:56,752 --> 04:40:58,921 PATIENTS AND THOSE WOULD BE GOOD 5749 04:40:58,921 --> 04:40:59,488 PARTNERS AS WELL. 5750 04:40:59,488 --> 04:41:02,458 I LIKE IT WAS LOOKING AT 5751 04:41:02,458 --> 04:41:04,260 DIVERSITY OF THE POPULATION AND 5752 04:41:04,260 --> 04:41:05,327 THE AGE CONSIDERATION. 5753 04:41:05,327 --> 04:41:09,732 I THOUGHT THOSE WERE ALL STRONG 5754 04:41:09,732 --> 04:41:12,201 AND POTENTIAL WEAKNESS SIDE I 5755 04:41:12,201 --> 04:41:15,638 THINK IT WAS VERY COMPREHENSIVE 5756 04:41:15,638 --> 04:41:18,908 AND THAT CERTAINLY IS A STRENGTH 5757 04:41:18,908 --> 04:41:19,909 BUT ALSO HAS POTENTIAL TO BE A 5758 04:41:19,909 --> 04:41:21,977 WEAKNESS AS WELL. 5759 04:41:21,977 --> 04:41:27,449 I THINK THAT PROBABLY FOR THE 5760 04:41:27,449 --> 04:41:34,924 NEXT PHASE TO CONSIDER HOW 5761 04:41:34,924 --> 04:41:35,891 COMPREHENSIVE YOU WANT IT WITH 5762 04:41:35,891 --> 04:41:38,594 THE APPLICATIONS TO HAVE THE 5763 04:41:38,594 --> 04:41:40,529 RIGHT STUDY SECTION MAKE UP TOO 5764 04:41:40,529 --> 04:41:43,899 TO REVIEW THOSE. 5765 04:41:43,899 --> 04:41:51,207 AS FAR AS SUSTAINABILITY, I 5766 04:41:51,207 --> 04:41:54,143 THINK EYE CRITICISM OF THE PBRN 5767 04:41:54,143 --> 04:41:55,778 ONES IS THE COMMUNITY-ENGAGED 5768 04:41:55,778 --> 04:42:02,318 RESEARCH IS TIME CONSUMING AND 5769 04:42:02,318 --> 04:42:05,688 RESOURCE INTENSIVE ONE NEEDS TO 5770 04:42:05,688 --> 04:42:07,756 KEEP AN EYE ON THAT. 5771 04:42:07,756 --> 04:42:08,390 THE POPULATIONS ARE SOMETIMES 5772 04:42:08,390 --> 04:42:11,927 DIFFICULT TO RECRUIT TO THESE 5773 04:42:11,927 --> 04:42:13,963 STUDY. 5774 04:42:13,963 --> 04:42:15,931 I THINK THAT'S GOING TO BE EYE 5775 04:42:15,931 --> 04:42:17,733 CHALLENGE GOING FORWARD AND WITH 5776 04:42:17,733 --> 04:42:25,875 THEP P BRNs WE NEED WELL 5777 04:42:25,875 --> 04:42:26,775 ESTABLISHED OUTCOME MEASURES SO 5778 04:42:26,775 --> 04:42:27,643 WHILE WE ARE DOING THIS 5779 04:42:27,643 --> 04:42:33,349 IMPORTANT RESEARCH WE HAVE THE 5780 04:42:33,349 --> 04:42:37,853 RIGHT OUTCOME MEASURES TO MAKE 5781 04:42:37,853 --> 04:42:39,154 DOES DECISIONS BUT THOUGHT IT 5782 04:42:39,154 --> 04:42:41,423 WAS A GOOD CONCEPT CLEARANCE AND 5783 04:42:41,423 --> 04:42:47,730 EXTRAORDINARY IMPORTANT TOPIC TO 5784 04:42:47,730 --> 04:42:52,534 CONTINUE TO LEARN MORE AND 5785 04:42:52,534 --> 04:42:53,202 CORRECT THESE INEQUITIES IN OUR 5786 04:42:53,202 --> 04:42:54,203 POPULATIONS. 5787 04:42:54,203 --> 04:43:00,576 >> THANK YOU VERY MUCH. 5788 04:43:00,576 --> 04:43:03,512 >> I GUESS IT'S ME NEXT. 5789 04:43:03,512 --> 04:43:05,514 IT'S HARD TO BELIEVE THIS 5790 04:43:05,514 --> 04:43:07,549 DECEMBER WELL REACH THE 40 YEAR 5791 04:43:07,549 --> 04:43:11,153 POINT OF AT WHICH TIME RYAN 5792 04:43:11,153 --> 04:43:14,657 WHITE OVERCAME THE DIAGNOSIS 5793 04:43:14,657 --> 04:43:15,624 WITH HIV. 5794 04:43:15,624 --> 04:43:19,228 AS A RESULT OF THAT THE CLOCK 5795 04:43:19,228 --> 04:43:24,233 WENT TO ZERO AND WE'D HAVE A 5796 04:43:24,233 --> 04:43:26,802 GENERATION. 5797 04:43:26,802 --> 04:43:28,504 AND BEGINNING IN 1990 WE MADE 5798 04:43:28,504 --> 04:43:31,040 STRIDES IN ADDRESSING NOT ONLY 5799 04:43:31,040 --> 04:43:31,840 THE INCIDENTS OF THE DISEASE BUT 5800 04:43:31,840 --> 04:43:35,911 THE TRAGIC FACT THAT WE SEE MANY 5801 04:43:35,911 --> 04:43:39,048 DISPARITIES ACROSS THE SPECTRUM 5802 04:43:39,048 --> 04:43:42,718 OF RACE, LOCATION, BELIEFS, 5803 04:43:42,718 --> 04:43:47,389 HEALTH DISPARITIES AND YET TODAY 5804 04:43:47,389 --> 04:43:53,629 THERE REMAINS THE GREATER 5805 04:43:53,629 --> 04:43:57,466 CHALLENGE OF BRINGING EQUALITY 5806 04:43:57,466 --> 04:43:59,902 TO POPULATIONS. 5807 04:43:59,902 --> 04:44:01,403 I BELIEVE WE'RE GETTING CLOSER 5808 04:44:01,403 --> 04:44:06,642 BUT WE STILL A MOUNTAIN OF 5809 04:44:06,642 --> 04:44:06,942 CHALLENGES. 5810 04:44:06,942 --> 04:44:09,311 YEAR AFTER YEAR WE CONTINUE TO 5811 04:44:09,311 --> 04:44:14,817 OBSERVE DISPARITIES IN VIRAL 5812 04:44:14,817 --> 04:44:17,453 SUPPRESSION AND POPULATIONS 5813 04:44:17,453 --> 04:44:22,524 FACING VIRAL SUPPRESSION. 5814 04:44:22,524 --> 04:44:27,896 THE CONCEPT WOULD ADDRESS THESE 5815 04:44:27,896 --> 04:44:30,299 DISPARITIES OF THE MOST 5816 04:44:30,299 --> 04:44:32,534 VULNERABLE WITH A TARGET 5817 04:44:32,534 --> 04:44:38,674 POPULATION IN RELEVANT 5818 04:44:38,674 --> 04:44:38,974 COMMUNITIES. 5819 04:44:38,974 --> 04:44:43,912 THESE ARE ALSO SCIENTIFIC 5820 04:44:43,912 --> 04:44:44,680 PROPOSALS. 5821 04:44:44,680 --> 04:44:52,621 IT ALSO DELIBERATELY ADDRESSES 5822 04:44:52,621 --> 04:44:54,156 THE INEQUALITY OF APPROPRIATE 5823 04:44:54,156 --> 04:44:55,157 CARE. 5824 04:44:55,157 --> 04:44:59,528 A KEY POINT IN MY OPINION TO BE 5825 04:44:59,528 --> 04:45:03,465 YOUR COMMENT OF PAYING ATTENTION 5826 04:45:03,465 --> 04:45:04,566 TO INTERSECTIONALITY. 5827 04:45:04,566 --> 04:45:07,603 THE MORE INEQUALITIES WE SEE THE 5828 04:45:07,603 --> 04:45:09,905 MORE BURDEN ON THE SCIENCE 5829 04:45:09,905 --> 04:45:11,073 COMMUNITY TO SEEK AND UNDERSTAND 5830 04:45:11,073 --> 04:45:19,381 THE MANY FACETS OF HOW A HIGHER 5831 04:45:19,381 --> 04:45:20,349 BURDEN AFFECT THE MENTAL WELL 5832 04:45:20,349 --> 04:45:21,483 BEING OF THESE POPULATIONS AND 5833 04:45:21,483 --> 04:45:26,255 IT'S NOT JUST A SIMPLE LINEAR 5834 04:45:26,255 --> 04:45:27,056 FACTOR RATHER ONE PLUS ONE 5835 04:45:27,056 --> 04:45:35,898 EQUALS THREE OR FOUR OR FIVE. 5836 04:45:35,898 --> 04:45:40,269 THE FAIRNESS AND EQUALITY. 5837 04:45:40,269 --> 04:45:45,741 STUDIES SEEM LIKE AT EVERY 5838 04:45:45,741 --> 04:45:51,480 CONCEPT OR ACTION WE CONTINUE TO 5839 04:45:51,480 --> 04:45:58,253 SEE THE SAME THINGS AND HOPE WE 5840 04:45:58,253 --> 04:46:02,224 CAN GIVE MORE ENERGY AS A DIRECT 5841 04:46:02,224 --> 04:46:03,959 RESULT OF CONTINUING TO SEE 5842 04:46:03,959 --> 04:46:09,431 HEALTH INEQUITIES WE SEE TODAY 5843 04:46:09,431 --> 04:46:13,001 HOW CAN WE ADDRESS THEM AND MAKE 5844 04:46:13,001 --> 04:46:15,737 SURE YOU USE ALL THE RESOURCES 5845 04:46:15,737 --> 04:46:16,738 OF THE RYAN WHITE ORGANIZATION 5846 04:46:16,738 --> 04:46:19,641 HAS AND THERE'S BEEN WORK IN ALL 5847 04:46:19,641 --> 04:46:22,377 THESE MANY MANY YEARS WITH THEIR 5848 04:46:22,377 --> 04:46:26,682 GOAL TRYING TO CREATE THE 5849 04:46:26,682 --> 04:46:37,192 GENERATION THAT'S FREE IN HIV. 5850 04:46:37,626 --> 04:46:39,495 OVER ALL THE CONCEPT IS GREAT 5851 04:46:39,495 --> 04:46:40,863 AND PAUL IDENTIFIED POSITIVE 5852 04:46:40,863 --> 04:46:43,832 THINGS ABOUT THE CONCEPT SO I 5853 04:46:43,832 --> 04:46:45,267 CERTAINLY ENCOURAGE YOU TO LOOK 5854 04:46:45,267 --> 04:46:45,868 FAVORABLY UPON THIS CONCEPT. 5855 04:46:45,868 --> 04:46:52,774 THANK YOU. 5856 04:46:52,774 --> 04:46:55,010 >> THANK YOU FOR YOUR REVIEW AND 5857 04:46:55,010 --> 04:46:55,444 IMPORTANT COMMENTS. 5858 04:46:55,444 --> 04:46:57,479 I TOOK NOTES AND WILL 5859 04:46:57,479 --> 04:47:03,285 INCORPORATE YOUR SUGGESTIONS. 5860 04:47:03,285 --> 04:47:07,589 >> ARE THERE ANY OTHER COMMENTS? 5861 04:47:07,589 --> 04:47:10,092 IF NOT WOULD A MEMBER LIKE TO 5862 04:47:10,092 --> 04:47:11,593 MOTION THE CONCEPT. 5863 04:47:11,593 --> 04:47:13,795 >> SO MOVED BY PAUL. 5864 04:47:13,795 --> 04:47:15,397 >> WOULD SOMEONE LIKE TO SECOND. 5865 04:47:15,397 --> 04:47:15,898 >> I'LL SECOND. 5866 04:47:15,898 --> 04:47:19,902 >> ALL IN FAVOR? 5867 04:47:19,902 --> 04:47:27,409 ANY OPPOSED? 5868 04:47:27,409 --> 04:47:27,676 THANK YOU. 5869 04:47:27,676 --> 04:47:31,480 WE'LL MOVE ON TO THE FINAL 5870 04:47:31,480 --> 04:47:36,251 CONCEPT BY TAMARA McNEALY. 5871 04:47:36,251 --> 04:47:37,519 >> GOOD AFTERNOON, EVERYONE. 5872 04:47:37,519 --> 04:47:41,190 I'M HERE TO SEEK COUNCIL'S 5873 04:47:41,190 --> 04:47:43,559 CONCURRENCE ON AN INITIATIVE 5874 04:47:43,559 --> 04:47:46,562 THAT ENTITLED MODULATING THE 5875 04:47:46,562 --> 04:47:48,964 MICROBIOME TOWARDS HEALTH. 5876 04:47:48,964 --> 04:47:50,699 HEALTHY ORAL MICROBIOME EXISTS 5877 04:47:50,699 --> 04:47:52,868 IN A STATE OF BALANCE. 5878 04:47:52,868 --> 04:47:54,870 THIS IMAGE REPRESENTS ALL THE 5879 04:47:54,870 --> 04:47:57,172 VARIOUS ASPECTS THAT ARE IN PLAY 5880 04:47:57,172 --> 04:47:59,074 WHEN WE TALK ABOUT THAT BALANCE. 5881 04:47:59,074 --> 04:48:02,778 IT'S NOT ONLY THE ORGANISMS 5882 04:48:02,778 --> 04:48:04,179 PRESENT BUT ALSO THOSE ORGANISMS 5883 04:48:04,179 --> 04:48:07,849 WITHIN A SPACE IN 5884 04:48:07,849 --> 04:48:08,217 GEOGRAPHY. 5885 04:48:08,217 --> 04:48:09,785 ONE A VARIABLE SHIFTS THE WHOLE 5886 04:48:09,785 --> 04:48:14,056 SYSTEM CAN BE AFFECTED. 5887 04:48:14,056 --> 04:48:19,328 WE KNOW ONCE PANEL GENIC ORG 5888 04:48:19,328 --> 04:48:22,564 MIXES SHIFT TOWARDS DYSBIOSIS 5889 04:48:22,564 --> 04:48:24,967 AND DISEASE IF IT CAN SHIFT TO 5890 04:48:24,967 --> 04:48:30,539 DISEASE WE CAN ASK HOW DO WE 5891 04:48:30,539 --> 04:48:32,608 SHIFT THE DISEASE MICROBIOME 5892 04:48:32,608 --> 04:48:33,442 BACK TOWARDS HEALTH. 5893 04:48:33,442 --> 04:48:36,678 IT'S TO FOCUS EFFORTS ON 5894 04:48:36,678 --> 04:48:37,546 UNDERSTANDING THE MICROBIOME AS 5895 04:48:37,546 --> 04:48:39,147 A COMMUNITY AND FOCUS ON 5896 04:48:39,147 --> 04:48:40,182 DEVELOPMENT OF MICROBIOME 5897 04:48:40,182 --> 04:48:42,918 DIRECTED THERAPIES FOR ORAL 5898 04:48:42,918 --> 04:48:43,619 DISEASE. 5899 04:48:43,619 --> 04:48:45,420 WE EXPECT THE OUTCOME AND 5900 04:48:45,420 --> 04:48:46,989 SUCCESSFUL PROJECTS WILL THEN 5901 04:48:46,989 --> 04:48:50,559 LEAD TO NOVEL OPTIONS THAT 5902 04:48:50,559 --> 04:48:52,027 MODULATE THE MICROBIOME 5903 04:48:52,027 --> 04:48:54,496 PROMOTING A RETURN TO OR 5904 04:48:54,496 --> 04:48:56,298 MAINTENANCE OF HEALTH WHILE 5905 04:48:56,298 --> 04:49:00,002 REDUCING THE RELIANCE ON 5906 04:49:00,002 --> 04:49:02,704 ANTIMICROBIALS AND ACHIEVING 5907 04:49:02,704 --> 04:49:04,339 IMPACT ONLY THE ORAL CAVITY 5908 04:49:04,339 --> 04:49:04,573 HEALTH. 5909 04:49:04,573 --> 04:49:14,049 THESE PLAY HAMAY HAVE POSITIVE 5910 04:49:14,049 --> 04:49:24,459 EFFECTS ON ORAL DISEASE. 5911 04:49:28,830 --> 04:49:30,165 RESEARCH IN THE ORAL MICROBIOME 5912 04:49:30,165 --> 04:49:32,467 FIELD HAS RESULTED IN THE WEALTH 5913 04:49:32,467 --> 04:49:38,040 OF DATA OF INDIVIDUAL ORGANISMS, 5914 04:49:38,040 --> 04:49:38,707 NEE 5915 04:49:38,707 --> 04:49:41,176 NICHES AND WE HAVE DATA IN 5916 04:49:41,176 --> 04:49:42,811 METABOLOMICS AND DATA ON THE 5917 04:49:42,811 --> 04:49:44,546 ORGANISMS PRESENT IN HEALTH AND 5918 04:49:44,546 --> 04:49:45,580 DISEASE SCENARIOS. 5919 04:49:45,580 --> 04:49:47,883 WE HAVE DATA FROM A VARIETY OF 5920 04:49:47,883 --> 04:49:51,486 IMAGING TECHNIQUES DEMONSTRATING 5921 04:49:51,486 --> 04:49:52,988 THE IMPORTANCE OF BIOGEOGRAPHY 5922 04:49:52,988 --> 04:49:55,090 AND SPATIAL STRUCTURE IN THE 5923 04:49:55,090 --> 04:49:55,490 MICROBIOME. 5924 04:49:55,490 --> 04:49:56,692 THOUGH OUR KNOWLEDGE OF 5925 04:49:56,692 --> 04:49:58,427 INTERPLAY HAS VASTLY IMPROVED 5926 04:49:58,427 --> 04:50:00,729 WITH ALL OF THIS INFORMATION, 5927 04:50:00,729 --> 04:50:02,264 THE TRANSLATION TO THERAPEUTICS 5928 04:50:02,264 --> 04:50:05,500 HAS SO FAR BEEN RATHER LIMITED. 5929 04:50:05,500 --> 04:50:09,471 WE HAVE A NEED TO HARNESS THE 5930 04:50:09,471 --> 04:50:11,840 DATA TO DEVELOP MORE ROBUST 5931 04:50:11,840 --> 04:50:12,974 PIPELINES FOR ORAL THERAPY. 5932 04:50:12,974 --> 04:50:15,277 YOU MIGHT ASK HOW DO WE KNOW 5933 04:50:15,277 --> 04:50:18,947 MODULATION OF THE MICROBIOME 5934 04:50:18,947 --> 04:50:19,548 WILL HELP? 5935 04:50:19,548 --> 04:50:21,350 WE CAN TAKE TWO EXAMPLES BECAUSE 5936 04:50:21,350 --> 04:50:23,885 WE KNOW AFTER AN INTENSIVE 5937 04:50:23,885 --> 04:50:25,654 PERIODONTAL TREATMENT IF YOU 5938 04:50:25,654 --> 04:50:27,856 MAIN TRAIN ORAL HYGIENE, HAVE 5939 04:50:27,856 --> 04:50:29,558 MORE FREQUENT DENTAL VISITS YOU 5940 04:50:29,558 --> 04:50:31,727 CAN PREVENT REOCCURRENCE. 5941 04:50:31,727 --> 04:50:33,395 YOU CAN MAINTAIN THAT HEALTHY 5942 04:50:33,395 --> 04:50:33,662 COMMUNITY. 5943 04:50:33,662 --> 04:50:35,897 WE ALSO KNOW THIS IS THE CASE 5944 04:50:35,897 --> 04:50:38,767 AFTER CARIES TREATMENT. 5945 04:50:38,767 --> 04:50:41,536 THIS SUGGESTS IT IS POSSIBLE TO 5946 04:50:41,536 --> 04:50:48,143 SHIFT THE MICROBIOME BACK TO 5947 04:50:48,143 --> 04:50:49,344 HOMEOSTASIS BUT WHAT IF WE CAN 5948 04:50:49,344 --> 04:50:51,146 DO IT IN A WAY THAT LEADS TO A 5949 04:50:51,146 --> 04:50:53,849 MORE STABLE, LONGER LASTING 5950 04:50:53,849 --> 04:50:55,917 MAINTENANCE WITHOUT ANTIBIOTICS 5951 04:50:55,917 --> 04:50:58,854 BECAUSE WE'RE PROVIDING SUPPORT 5952 04:50:58,854 --> 04:51:01,656 TO THE HEALTHY MICROBIOME? 5953 04:51:01,656 --> 04:51:03,358 MICROBIOME DIRECTED THERAPIES 5954 04:51:03,358 --> 04:51:04,726 HAVE BEEN AROUND FOR A WHILE AND 5955 04:51:04,726 --> 04:51:06,428 GAINED ATTENTION THROUGH WORK IN 5956 04:51:06,428 --> 04:51:08,530 THE GUT MICROBIOME FIELD. 5957 04:51:08,530 --> 04:51:09,731 PARTICULARLY WITH THE SUCCESSION 5958 04:51:09,731 --> 04:51:13,034 OF USING THE FECAL MICROBIOME 5959 04:51:13,034 --> 04:51:15,570 TRANSPLANT TO RESTORE A HEALTHY 5960 04:51:15,570 --> 04:51:23,545 GUT MICROBIOTA WITH C DIVI SILL 5961 04:51:23,545 --> 04:51:26,381 AND LED TO CURE RATE. 5962 04:51:26,381 --> 04:51:29,384 SINCE THEN A NUMBER OF THERAP 5963 04:51:29,384 --> 04:51:32,487 HAVE BEEN INVESTIGATED AND NOW 5964 04:51:32,487 --> 04:51:35,924 WE CAN CONSIDER THERE ARE 5965 04:51:35,924 --> 04:51:37,459 GENERALLY FOUR CATEGORIES. 5966 04:51:37,459 --> 04:51:41,530 DIET AND PROBIOTICS THAT TARGET 5967 04:51:41,530 --> 04:51:43,899 EXPANSION OF ORGANISM, 5968 04:51:43,899 --> 04:51:46,168 RECONSTITUTION WITH BACTERIAL 5969 04:51:46,168 --> 04:51:49,538 CONSORTIA, THE USE OF ENGINEERED 5970 04:51:49,538 --> 04:51:50,071 MICROBIOTA AND BIO ACTIVE 5971 04:51:50,071 --> 04:52:00,248 COMPOUNDS. 5972 04:52:08,523 --> 04:52:11,893 DEF WE LOOK AT HOW THE 5973 04:52:11,893 --> 04:52:13,195 MICROBIOTA SUPPORT, TOLERATE OR 5974 04:52:13,195 --> 04:52:14,930 REJECT EACH EITHER WITHIN THE 5975 04:52:14,930 --> 04:52:16,531 COMMUNITY ENVIRONMENT AND HOW TO 5976 04:52:16,531 --> 04:52:19,000 SELECT THOSE BEST FIT FOR 5977 04:52:19,000 --> 04:52:21,970 THERAPEUTIC USE. 5978 04:52:21,970 --> 04:52:22,671 MICROBIOTA DIRECTED 5979 04:52:22,671 --> 04:52:25,607 COMPLEMENTARY DIETS AND HOW THAT 5980 04:52:25,607 --> 04:52:27,909 RELATES TO DYSBIOSIS OF A 5981 04:52:27,909 --> 04:52:31,880 COMMUNITY AND TARGETING OF 5982 04:52:31,880 --> 04:52:32,914 PATHOGENIC SPECIES AND 5983 04:52:32,914 --> 04:52:34,883 COMPUTATIONAL APPROACHES TO 5984 04:52:34,883 --> 04:52:36,718 PREDICT, ANALYZE AND MONITOR HOW 5985 04:52:36,718 --> 04:52:37,552 COMMUNITIES TRANSITION BETWEEN 5986 04:52:37,552 --> 04:52:39,921 HEALTH AND DYSBIOSIS. 5987 04:52:39,921 --> 04:52:42,190 SMALL MOLECULE THERAPEUTICS AND 5988 04:52:42,190 --> 04:52:44,960 MEDIATORS AND INTEGRATION OF THE 5989 04:52:44,960 --> 04:52:47,162 OMICS-BASED APPROACHES 5990 04:52:47,162 --> 04:52:50,665 PARTICULARLY THE METABOLOMICS TO 5991 04:52:50,665 --> 04:52:52,634 HELP EXAMINE HOW ORAL 5992 04:52:52,634 --> 04:52:54,102 COMMUNITIES CHANGE FUNCTIONALLY 5993 04:52:54,102 --> 04:52:57,472 AND TAXONOMICLY OVER TIME TO 5994 04:52:57,472 --> 04:52:58,073 TARGET DEVELOPMENT FOR 5995 04:52:58,073 --> 04:53:04,513 MODULATION THERAPY. 5996 04:53:04,513 --> 04:53:07,782 SO SOME SPECIFIC COMBRARZ OF 5997 04:53:07,782 --> 04:53:08,450 INTEREST INCLUDE TARGETED PANEL 5998 04:53:08,450 --> 04:53:13,622 GEN ELIMINATION THERAPIES, 5999 04:53:13,622 --> 04:53:14,856 COMMENSAL DRIVEN MODULATION 6000 04:53:14,856 --> 04:53:16,091 STRATEGIES AND MECHANISMS 6001 04:53:16,091 --> 04:53:17,325 DRIVING THE COMMUNITY FROM 6002 04:53:17,325 --> 04:53:20,495 DYSBIOSIS TO HEALTH AND TARGETED 6003 04:53:20,495 --> 04:53:22,931 THERAPIES AFFECTING HOMEOSTASIS. 6004 04:53:22,931 --> 04:53:25,233 WE HOPE TO ENCOURAGE THE FIELD 6005 04:53:25,233 --> 04:53:27,302 TO BUILD UPON THE CURRENT WEALTH 6006 04:53:27,302 --> 04:53:30,872 OF DATA FROM THE ORAL AS WELL AS 6007 04:53:30,872 --> 04:53:34,276 FROM OTHER MICROBIOME FIELD AND 6008 04:53:34,276 --> 04:53:35,677 DEVELOP THERAPEUTIC OPTIONS 6009 04:53:35,677 --> 04:53:37,412 BASED ON UNDERSTANDING OF THE 6010 04:53:37,412 --> 04:53:38,013 MICROBIOME RELATIONSHIP AND 6011 04:53:38,013 --> 04:53:38,680 COMMUNITY FUNCTIONS. 6012 04:53:38,680 --> 04:53:43,184 THE OTHER ASPECT IS THAT WE 6013 04:53:43,184 --> 04:53:45,487 UNDERSTAND THE DEGREE OF 6014 04:53:45,487 --> 04:53:46,288 INTERINDIVIDUAL VARIABILITY OF 6015 04:53:46,288 --> 04:53:47,789 THE ORAL MICROBIOME DOES SUGGEST 6016 04:53:47,789 --> 04:53:50,358 A PERSONALIZED TARGETED AND 6017 04:53:50,358 --> 04:53:52,627 DEFINED APPROACH TO THERAPY MAY 6018 04:53:52,627 --> 04:53:55,897 OFFER GREATER CHANCES OF 6019 04:53:55,897 --> 04:54:00,135 THERAPEUTIC SUCCESS. 6020 04:54:00,135 --> 04:54:02,370 OUR TWO COUNCIL REVIEWERS THAT 6021 04:54:02,370 --> 04:54:05,273 AGREED TO ASSESS THIS INITIATIVE 6022 04:54:05,273 --> 04:54:07,909 OR CONCEPT ARE DR. NOR AND 6023 04:54:07,909 --> 04:54:08,143 DR. KOO. 6024 04:54:08,143 --> 04:54:09,711 THANK YOU. 6025 04:54:09,711 --> 04:54:10,612 >> I THINK DR. KOO IS GOING TO 6026 04:54:10,612 --> 04:54:20,789 GO FIRST. 6027 04:54:24,125 --> 04:54:25,927 >> THANK YOU. 6028 04:54:25,927 --> 04:54:28,296 VERY NICELY PUT TOGETHER. 6029 04:54:28,296 --> 04:54:31,066 OFF THE BAT I'M VERY 6030 04:54:31,066 --> 04:54:34,302 ENTHUSIASTIC ABOUT THE CONCEPT. 6031 04:54:34,302 --> 04:54:37,839 I THINK YOU PUT IT VERY WELL 6032 04:54:37,839 --> 04:54:40,575 TOGETHER THE REASONS AND I THINK 6033 04:54:40,575 --> 04:54:44,646 IT'S A NATURAL EVOLUTION OF THE 6034 04:54:44,646 --> 04:54:45,780 INITIATIVES IN THE MICROBIOME 6035 04:54:45,780 --> 04:54:50,518 AND RECENT NOSI ON THE 6036 04:54:50,518 --> 04:54:51,019 FUNCTIONAL MICROBIOME. 6037 04:54:51,019 --> 04:54:53,221 A NATURAL EVOLUTION TO TRY TO 6038 04:54:53,221 --> 04:54:55,890 FIND THERAPEUTIC APPROACHES TO 6039 04:54:55,890 --> 04:55:01,529 MODULATE. 6040 04:55:01,529 --> 04:55:10,872 I THINK SOME ENTHUSIASM WITH THE 6041 04:55:10,872 --> 04:55:17,946 HIGH IMPACT AND THERE'S ORAL AND 6042 04:55:17,946 --> 04:55:23,918 SYSTEMIC HEALTH COMPONENTS 6043 04:55:23,918 --> 04:55:25,253 ALLOWING COLLABORATION IN 6044 04:55:25,253 --> 04:55:26,221 CHECKING THE RIGHT BOXES. 6045 04:55:26,221 --> 04:55:33,461 I LIKE THE IDEA OF THE 6046 04:55:33,461 --> 04:55:35,697 CONSORTIA-BASED THERAPY. 6047 04:55:35,697 --> 04:55:38,833 I CHOSE TO BRING UP IF HE 6048 04:55:38,833 --> 04:55:41,436 CHALLENGES OF MODULATING THE 6049 04:55:41,436 --> 04:55:43,905 MICROBIOME ESPECIALLY ORAL 6050 04:55:43,905 --> 04:55:44,806 MICROBIOME AND CAN SUMMARIZE 6051 04:55:44,806 --> 04:55:46,107 MAYBE THREE REASONS WHY IT'S A 6052 04:55:46,107 --> 04:55:53,048 CHALLENGING APPROACH. 6053 04:55:53,048 --> 04:55:55,917 ONE IS IT'S HIGHLY DYNAMIC IN 6054 04:55:55,917 --> 04:55:59,387 NATURE. 6055 04:55:59,387 --> 04:56:01,089 THE MICROBIOTA IS THE MOST 6056 04:56:01,089 --> 04:56:11,533 DYNAMIC IN THE HUMAN BODY. 6057 04:56:12,734 --> 04:56:16,271 TWO THERE'S MEDICAL VARIATES AND 6058 04:56:16,271 --> 04:56:21,843 HOW THEY NEED TO BE ADJUSTED. 6059 04:56:21,843 --> 04:56:26,114 AND THE THIRD AND IT'S HARD TO 6060 04:56:26,114 --> 04:56:27,449 CHANGE THE MICROBIOTA ONCE 6061 04:56:27,449 --> 04:56:28,083 ESTABLISHED ESPECIALLY 6062 04:56:28,083 --> 04:56:31,820 NATURALLY. 6063 04:56:31,820 --> 04:56:34,622 SO THOSE ARE THE THREE REASONS I 6064 04:56:34,622 --> 04:56:35,890 THINK THERE'S CHALLENGES IN 6065 04:56:35,890 --> 04:56:39,694 TERMS OF MODULATE BEING THE 6066 04:56:39,694 --> 04:56:44,766 MICROBIOTA BUT TO ME IT BRINGS 6067 04:56:44,766 --> 04:56:47,168 OPPORTUNITIES AND INNOVATIVE 6068 04:56:47,168 --> 04:56:52,006 APPROACH TO MAKE CHANGES IN 6069 04:56:52,006 --> 04:56:55,176 MODULATING THE MICROBIOME. 6070 04:56:55,176 --> 04:56:58,046 IN TERMS OF SUGGESTIONS, THE KEY 6071 04:56:58,046 --> 04:57:01,282 POINTS YOU PUT TOGETHER THE 6072 04:57:01,282 --> 04:57:03,852 FOCUS AREAS ARE ALL GREAT AND I 6073 04:57:03,852 --> 04:57:05,720 THINK THOSE HAVE NO COMMENTS. 6074 04:57:05,720 --> 04:57:07,355 THOSE ARE EXCITING AND VERY 6075 04:57:07,355 --> 04:57:11,893 IMPORTANT BUT MAYBE IF I CAN 6076 04:57:11,893 --> 04:57:15,463 SUMMARIZE THREE AREAS THAT COULD 6077 04:57:15,463 --> 04:57:21,469 BE IMPROVED. 6078 04:57:21,469 --> 04:57:23,471 ONE, OMICS IS GREAT. 6079 04:57:23,471 --> 04:57:26,374 MULTI-OMICS AND I THINK OMICS 6080 04:57:26,374 --> 04:57:29,978 WITHOUT SPATIAL AND TEMPORAL 6081 04:57:29,978 --> 04:57:32,714 INFORMATION WILL BE LIMITED. 6082 04:57:32,714 --> 04:57:33,815 BY INTEGRATING THE SPATIAL 6083 04:57:33,815 --> 04:57:37,051 ASPECTS ARE CRITICAL AND WHAT WE 6084 04:57:37,051 --> 04:57:41,055 ARE LEARNING FROM THE FUNCTIONAL 6085 04:57:41,055 --> 04:57:42,791 MICROBIOME STUDY. 6086 04:57:42,791 --> 04:57:43,691 AND WHAT'S IMPORTANT FOR THE 6087 04:57:43,691 --> 04:57:49,097 CONCEPT IS TO CONSIDER THE HOST 6088 04:57:49,097 --> 04:57:49,330 FACTORS. 6089 04:57:49,330 --> 04:57:51,900 THE GENETICS AND DIET SHOULD BE 6090 04:57:51,900 --> 04:57:55,904 INCLUDED IN TERMS OF MODULATING 6091 04:57:55,904 --> 04:57:58,907 THE MICROBIAL. 6092 04:57:58,907 --> 04:58:02,477 THERE'S HOST MICROBE 6093 04:58:02,477 --> 04:58:03,912 INTERACTIONS WHEN YOU GO TO 6094 04:58:03,912 --> 04:58:05,113 COMPUTATIONAL APPROACHES. 6095 04:58:05,113 --> 04:58:07,916 THE HOST FACTORS NEED TO BE 6096 04:58:07,916 --> 04:58:10,652 THERE. 6097 04:58:10,652 --> 04:58:15,290 I LIKE YOU'RE LOOKING FOR NEW 6098 04:58:15,290 --> 04:58:22,230 MOLECULES AND EVEN NEW M 6099 04:58:22,230 --> 04:58:27,502 METABOLITES TO MODULATE IS COOL. 6100 04:58:27,502 --> 04:58:31,906 IN ADDITION TO PROVIDE THE DOSE 6101 04:58:31,906 --> 04:58:35,777 BIOLOGICS OR EVEN MOLECULES I 6102 04:58:35,777 --> 04:58:37,712 THINK THE KEY CHALLENGE IS HOW 6103 04:58:37,712 --> 04:58:41,316 DELIVER THEM AND HOW TO RETAIN 6104 04:58:41,316 --> 04:58:46,621 THOSE MOLECULES OR BIOLOGICS OR 6105 04:58:46,621 --> 04:58:48,890 MICROBIOME WITHIN THE COMMUNITY. 6106 04:58:48,890 --> 04:58:52,026 THE ORAL CAVITY IS DYNAMIC, YOU 6107 04:58:52,026 --> 04:58:57,532 DRINK ALL THE TIME AND EAT AND 6108 04:58:57,532 --> 04:58:58,466 SWALLOWING. 6109 04:58:58,466 --> 04:59:03,538 SO RETAINING THOSE BIOLOGICS IS 6110 04:59:03,538 --> 04:59:07,876 VERY IMPORTANT. 6111 04:59:07,876 --> 04:59:09,978 OVER ALL VERY SUPPORTIVE AND 6112 04:59:09,978 --> 04:59:12,146 ENTHUSIASTIC AND IT NEEDS TO BE 6113 04:59:12,146 --> 04:59:18,853 DONE BUT AS A SUGGESTION MAY BE 6114 04:59:18,853 --> 04:59:20,421 INTEGRATE THE SPATIAL TEMPORAL 6115 04:59:20,421 --> 04:59:25,660 INFORMATION AND SPATIAL IMAGING 6116 04:59:25,660 --> 04:59:29,097 AND THE HOST FACTORS AND 6117 04:59:29,097 --> 04:59:32,400 EMPHASIZE NOT ONLY THERAPEUTIC 6118 04:59:32,400 --> 04:59:34,802 DEVELOPMENT BUT ALSO DELIVERY 6119 04:59:34,802 --> 04:59:39,908 AND RETENTION OF THOSE AGENTS. 6120 04:59:39,908 --> 04:59:42,410 FINALLY ONE POINT THAT'S 6121 04:59:42,410 --> 04:59:47,916 IMPORTANT I KNOW YOU EMPHASIZED 6122 04:59:47,916 --> 04:59:50,184 THE MECHANISMS OF DYSBIOSIS AND 6123 04:59:50,184 --> 04:59:51,352 IT'S IMPORTANT TO DEVELOP 6124 04:59:51,352 --> 04:59:52,553 METHODS TO ASSESS THE MECHANISMS 6125 04:59:52,553 --> 04:59:55,490 IN THE ONLY THE MODELS BUT THE 6126 04:59:55,490 --> 04:59:58,293 ASSESS THE MECHANISMS. 6127 04:59:58,293 --> 05:00:01,229 THOSE ARE ALL SUGGESTIONS. 6128 05:00:01,229 --> 05:00:03,364 OVER ALL HIGHLY ENTHUSIASTIC AND 6129 05:00:03,364 --> 05:00:08,069 SUPPORTIVE OF THIS CONCEPT. 6130 05:00:08,069 --> 05:00:09,337 >> THANK YOU. 6131 05:00:09,337 --> 05:00:11,039 THOSE ARE ALL GREAT SUGGESTIONS. 6132 05:00:11,039 --> 05:00:12,106 I APPRECIATE YOU TAKING THE TIME 6133 05:00:12,106 --> 05:00:15,543 TO PROVIDE THOSE. 6134 05:00:15,543 --> 05:00:17,812 THANKS. 6135 05:00:17,812 --> 05:00:22,684 IS 6136 05:00:22,684 --> 05:00:33,227 >> I AGREE MICHEL AND SUMMARIZED 6137 05:00:33,594 --> 05:00:36,831 THE CONCEPT AND I THINK YOU DID 6138 05:00:36,831 --> 05:00:41,903 A TERRIFIC JOB PUTTING THE 6139 05:00:41,903 --> 05:00:45,139 CONCEPT TOGETHER. 6140 05:00:45,139 --> 05:00:48,576 AND ONE IMPORTANT DIRECTION I 6141 05:00:48,576 --> 05:00:51,546 THINK FOR THE NIDCR. 6142 05:00:51,546 --> 05:00:55,850 I HAVE SEEN OVER THE LAST 20, 30 6143 05:00:55,850 --> 05:00:58,619 YEARS LOTS OF DESCRIPTIVE 6144 05:00:58,619 --> 05:01:03,257 STUDIES AND CORRELATIONAL 6145 05:01:03,257 --> 05:01:05,259 STUDIES BETWEEN MICROBIOME AND 6146 05:01:05,259 --> 05:01:06,160 CERTAIN DISEASES. 6147 05:01:06,160 --> 05:01:10,031 IT'S REALLY TIME NOW TO MOVE THE 6148 05:01:10,031 --> 05:01:13,634 FIELD FORWARD BEYOND THE 6149 05:01:13,634 --> 05:01:15,269 DESCRIPTIVE AND CORRELATIONAL 6150 05:01:15,269 --> 05:01:19,907 STUDIES AND THINKING HOW TO 6151 05:01:19,907 --> 05:01:24,679 APPLY THE 23407KNOWLEDGE TO 6152 05:01:24,679 --> 05:01:24,946 THERAPIES. 6153 05:01:24,946 --> 05:01:26,014 AS I LOOK AT THE FIELD I CAN 6154 05:01:26,014 --> 05:01:32,453 COMPARE IT TO THE ONCOLOGY 6155 05:01:32,453 --> 05:01:32,653 FIELD. 6156 05:01:32,653 --> 05:01:36,591 WE USED TO USE NON-SPECIFIC 6157 05:01:36,591 --> 05:01:39,360 CHEMO THERAPIES AND MOVED TO 6158 05:01:39,360 --> 05:01:40,194 TARGETED THERAPIES FOR TREATMENT 6159 05:01:40,194 --> 05:01:50,638 AND PREVENTION OF CANCER. 6160 05:01:51,139 --> 05:01:55,109 IN THE ORAL CAVITY WE'RE USING 6161 05:01:55,109 --> 05:01:57,545 THERAPY AND OTHER THERAPIES IT'S 6162 05:01:57,545 --> 05:02:00,681 TIME TO MOVE IT FORWARD TOWARD 6163 05:02:00,681 --> 05:02:03,584 MORE PRECISION DENTISTRY AND 6164 05:02:03,584 --> 05:02:06,187 PRECISE TARGETED TREATMENTS. 6165 05:02:06,187 --> 05:02:15,530 I THINK THIS CONCEPT REALLY 6166 05:02:15,530 --> 05:02:17,298 FOSTERS THE FIELD INTO THE RIGHT 6167 05:02:17,298 --> 05:02:17,598 DIRECTION. 6168 05:02:17,598 --> 05:02:19,967 ONE COMMENT ALONG THESE LINES IS 6169 05:02:19,967 --> 05:02:23,604 WHEN WE THINK ABOUT MICROBIOME 6170 05:02:23,604 --> 05:02:31,846 AND ORAL CAVITY WE THINK OF 6171 05:02:31,846 --> 05:02:34,215 CARIES AND ORAL DON TAL DISEASE 6172 05:02:34,215 --> 05:02:39,921 AND THE LINK BETWEEN MICROBIOME 6173 05:02:39,921 --> 05:02:43,224 AND PHARYNGEAL CANCER IS 6174 05:02:43,224 --> 05:02:44,425 BECOMING MORE ESTABLISHED. 6175 05:02:44,425 --> 05:02:46,394 MICHEL DID A WONDERFUL JOB 6176 05:02:46,394 --> 05:02:49,464 GIVING YOU GOOD SUGGESTIONS. 6177 05:02:49,464 --> 05:02:52,967 I THINK THIS A TERRIFIC CONCEPT 6178 05:02:52,967 --> 05:02:58,973 AND HIGHLY IMPACTFUL AND TIMELY 6179 05:02:58,973 --> 05:03:01,442 RAND CONSEQUENTIAL AND I WANT TO 6180 05:03:01,442 --> 05:03:03,311 CONGRATULATE YOU ON PUTTING THIS 6181 05:03:03,311 --> 05:03:03,578 TOGETHER. 6182 05:03:03,578 --> 05:03:03,911 >> THANK YOU. 6183 05:03:03,911 --> 05:03:06,013 WE TALKED ABOUT THE INCLUSION OF 6184 05:03:06,013 --> 05:03:09,584 THE ORAL CANCER AS WELL. 6185 05:03:09,584 --> 05:03:16,491 >> ANY OTHER COMMENTS? 6186 05:03:16,491 --> 05:03:16,757 QUESTIONS? 6187 05:03:16,757 --> 05:03:18,292 IF NOT WOULD A MEMBER LIKE TO 6188 05:03:18,292 --> 05:03:21,095 MAKE A MOTION TO APPROVE THE 6189 05:03:21,095 --> 05:03:21,529 CONCEPT. 6190 05:03:21,529 --> 05:03:23,898 >> I MAKE THE MOTION. 6191 05:03:23,898 --> 05:03:29,537 >> I CAN SECOND IT. 6192 05:03:29,537 --> 05:03:32,640 >> ALL IN FAVOR? 6193 05:03:32,640 --> 05:03:35,176 ANY OPPOSED? 6194 05:03:35,176 --> 05:03:35,810 OKAY. 6195 05:03:35,810 --> 05:03:39,547 SO THAT CONCLUDES THE OPEN 6196 05:03:39,547 --> 05:03:40,248 SESSION. 6197 05:03:40,248 --> 05:03:42,250 SO THANK YOU VERY MUCH EVERYONE. 6198 05:03:42,250 --> 05:03:45,553 I JUST WOULD LIKE TO MAKE 6199 05:03:45,553 --> 05:03:47,321 COMMENTS BEFORE I INVITE CLOSING 6200 05:03:47,321 --> 05:03:54,962 COMMENTS FROM JENNIFER WE DO 6201 05:03:54,962 --> 05:03:58,466 HAVE AN UPCOMING MEETING IN 6202 05:03:58,466 --> 05:04:08,543 JANUARY 22, 2025. 6203 05:04:08,543 --> 05:04:10,044 WE'RE RUNNING A LITTLE LATE ON 6204 05:04:10,044 --> 05:04:13,214 TIME SO MAYBE WE CAN BEGIN THE 6205 05:04:13,214 --> 05:04:14,248 CLOSED SESSION AT 4:00 P.M. IF 6206 05:04:14,248 --> 05:04:14,916 THAT'S OKAY. 6207 05:04:14,916 --> 05:04:16,751 WE LOOK FORWARD TO YOUR 6208 05:04:16,751 --> 05:04:17,018 COMMENTS. 6209 05:04:17,018 --> 05:04:19,587 WE HAVE A SLIDE THAT SHOWS THE 6210 05:04:19,587 --> 05:04:21,556 E-MAIL ADDRESS WHERE YOU CAN 6211 05:04:21,556 --> 05:04:25,593 PROVIDE COMMENTS AFTER THE 6212 05:04:25,593 --> 05:04:29,430 MEETING AND THERE'S A NEW LINK 6213 05:04:29,430 --> 05:04:32,633 FOR THE CLOSED SESSION. 6214 05:04:32,633 --> 05:04:33,901 CHECK YOUR CALENDAR AND USE THE 6215 05:04:33,901 --> 05:04:35,870 ZOOM LINK FOR THE CLOSED 6216 05:04:35,870 --> 05:04:36,170 SESSION. 6217 05:04:36,170 --> 05:04:40,041 WITH THAT I'LL TURN IT OVER TO 6218 05:04:40,041 --> 05:04:42,109 JENNIFER OR HER FINAL COMMENTS. 6219 05:04:42,109 --> 05:04:42,777 >> THANK YOU, LYNN. 6220 05:04:42,777 --> 05:04:44,545 THANK YOU ALL FOR JOINING US 6221 05:04:44,545 --> 05:04:45,546 TODAY. 6222 05:04:45,546 --> 05:04:49,517 A SPECIAL THANKS TO ALL OF US 6223 05:04:49,517 --> 05:04:55,890 AND STAMP COLLEAGUES AND 6224 05:04:55,890 --> 05:04:57,291 CLINICAL SCIENTIST TRAINING AND 6225 05:04:57,291 --> 05:05:00,394 PROGRAM STAFF ON THE INNOVATIVE 6226 05:05:00,394 --> 05:05:03,397 INITIATIVES TOWARDS REACHING OUR 6227 05:05:03,397 --> 05:05:06,534 GOAL OF ORAL HEALTH AND OVERALL 6228 05:05:06,534 --> 05:05:07,568 WELL BEING FOR ALL THERE'S A LOT 6229 05:05:07,568 --> 05:05:07,835 TO DO. 6230 05:05:07,835 --> 05:05:09,370 WE NEED TO DO IT TOGETHER FROM 6231 05:05:09,370 --> 05:05:12,707 THE FOUNDATIONAL SCIENCE LEVEL 6232 05:05:12,707 --> 05:05:14,175 OUT TO THE POPULATION. 6233 05:05:14,175 --> 05:05:15,910 IN COLLABORATION WITH OTHER 6234 05:05:15,910 --> 05:05:18,112 INSTITUTES AND FEDERAL AGENCIES. 6235 05:05:18,112 --> 05:05:20,348 SO LET'S TOGETHER MAKE A 6236 05:05:20,348 --> 05:05:21,015 DIFFERENCE AND HAVE A WONDERFUL 6237 05:05:21,015 --> 05:05:21,549 REST OF THE DAY. 6238 05:05:21,549 --> 05:05:21,616 6239 05:05:25,886 --> 05:05:26,387 I'LL SEE YOU COUNCIL IN THE 6240 05:05:26,387 --> 05:05:26,754 CLOSED SESSION. 6241 05:05:26,754 --> 05:05:27,488 6242 05:05:33,594 --> 05:05:35,129 >> THE OPEN SESSION IS NOW 6243 05:05:35,129 --> 05:05:35,396 ADJOURNED. 6244 05:05:35,396 --> 05:05:35,463