1 00:00:05,480 --> 00:00:08,320 >>WELCOME, EVERYONE. 2 00:00:08,320 --> 00:00:11,840 I WOULD LIKE TO WELCOME YOU TO 3 00:00:11,840 --> 00:00:15,160 THE 162nd MEETING OF THE 4 00:00:15,160 --> 00:00:18,880 NATIONAL ADVISORY COUNCIL ON 5 00:00:18,880 --> 00:00:22,000 ALCOHOL AND ALCOHOLISM. 6 00:00:22,000 --> 00:00:24,480 TO THE FIRST THING WE'LL DO IS 7 00:00:24,480 --> 00:00:26,680 HAVE EACH OF YOU INTRODUCE 8 00:00:26,680 --> 00:00:27,040 YOURSELVES. 9 00:00:27,040 --> 00:00:37,240 WE'LL GO IN ALPHABETICAL ORDER 10 00:00:37,240 --> 00:00:38,880 ANNOUNCE YOUR NAME AND 11 00:00:38,880 --> 00:00:41,000 INSTITUTION AND ONE LINE ABOUT 12 00:00:41,000 --> 00:00:45,920 YOUR EXPERTISE. 13 00:00:45,920 --> 00:00:48,120 YOU DON'T HAVE TO BE SHY. 14 00:00:48,120 --> 00:00:49,320 DR. NANCY BARNETT. 15 00:00:49,320 --> 00:00:51,560 >>WE CAN GET BACK TO HER -- 16 00:00:51,560 --> 00:00:53,400 >>I'M HERE. 17 00:00:53,400 --> 00:00:54,880 >>OKAY. 18 00:00:54,880 --> 00:00:56,640 >>I KNEW I'D BE FIRST. 19 00:00:56,640 --> 00:01:00,000 HI, NANCY BARNETT. 20 00:01:00,000 --> 00:01:01,800 I'M AT BROWN UNIVERSITY AT THE 21 00:01:01,800 --> 00:01:03,040 DEPARTMENT OF BEHAVIORAL AND 22 00:01:03,040 --> 00:01:05,000 SOCIAL SCIENCES IN THE SCHOOL OF 23 00:01:05,000 --> 00:01:07,360 PUBLIC HEALTH AND MY PRIMARY 24 00:01:07,360 --> 00:01:09,880 AREAS OF RESEARCH ARE EMERGING 25 00:01:09,880 --> 00:01:12,360 ADULTS AND COLLEGE STUDENTS AND 26 00:01:12,360 --> 00:01:14,680 THEIR PROBLEMS THEY HAVE AND THE 27 00:01:14,680 --> 00:01:16,480 INTERVENTIONS THAT SEEM TO WORK 28 00:01:16,480 --> 00:01:18,880 INCLUDING I LIKE TO USE REMOTE 29 00:01:18,880 --> 00:01:23,520 MONITORING INCLUDING SENSORS AND 30 00:01:23,520 --> 00:01:25,480 I STUDY SOCIAL NETWORKS AND 31 00:01:25,480 --> 00:01:27,960 BYSTANDER INTERVENTION TO ARE 32 00:01:27,960 --> 00:01:31,240 REDUCE THE HARMS ASSOCIATED WITH 33 00:01:31,240 --> 00:01:31,720 ALCOHOL USE. 34 00:01:31,720 --> 00:01:33,000 >>AND 35 00:01:33,000 --> 00:01:34,720 >>NANCY IS GOING TO TALK ABOUT 36 00:01:34,720 --> 00:01:37,160 SOME OF HER WORK THIS AFTERNOON. 37 00:01:37,160 --> 00:01:38,200 DR. JILL BECKER. 38 00:01:38,200 --> 00:01:39,600 >>I'M JILL BECKER FROM THE 39 00:01:39,600 --> 00:01:40,720 UNIVERSITY OF MICHIGAN. 40 00:01:40,720 --> 00:01:42,840 I'M IN THE DEPARTMENT OF 41 00:01:42,840 --> 00:01:45,000 PSYCHOLOGY AND THE MICHIGAN 42 00:01:45,000 --> 00:01:46,280 NEUROSCIENCE INSTITUTE. 43 00:01:46,280 --> 00:01:48,880 I STUDY SEX DIFFERENCES IN 44 00:01:48,880 --> 00:01:53,000 ADDICTION AND MOTIVATION USING 45 00:01:53,000 --> 00:01:55,720 ANIMAL MODELS. 46 00:01:55,720 --> 00:01:57,320 >>DR. ANDREW CAMERON. 47 00:01:57,320 --> 00:01:59,160 >>I'M AT JOHNS HOPKINS IN 48 00:01:59,160 --> 00:02:00,520 BALTIMORE A MEMBER OF THE 49 00:02:00,520 --> 00:02:02,760 DEPARTMENT OF SURGERY AND LIVER 50 00:02:02,760 --> 00:02:03,360 TRANSPLANT SURGEON THERE AND 51 00:02:03,360 --> 00:02:06,840 WE'RE INTERESTED IN LOOKING AT 52 00:02:06,840 --> 00:02:09,280 THE USE OF LIVER TRANSPLANT AS A 53 00:02:09,280 --> 00:02:11,000 THERAPEUTIC INTERVENTION FOR 54 00:02:11,000 --> 00:02:14,240 SEVERE ALCOHOL HEPATITIS. 55 00:02:14,240 --> 00:02:16,840 >>THANKS. 56 00:02:16,840 --> 00:02:19,560 >>I'M CHRIS CARPENTER AN 57 00:02:19,560 --> 00:02:20,120 ECONOMIST AT VANDERBILT 58 00:02:20,120 --> 00:02:23,080 UNIVERSITY AND STUDY PUBLIC 59 00:02:23,080 --> 00:02:24,880 POLICY AND WE'RE FOLKS. 60 00:02:24,880 --> 00:02:30,880 -- QUEER FOLKS. 61 00:02:30,880 --> 00:02:35,720 >>DR. CHAMBERS. 62 00:02:35,720 --> 00:02:38,560 >>SHE'S NOT ONLINE. 63 00:02:38,560 --> 00:02:41,120 >>WE'LL CATCH HER LATER. 64 00:02:41,120 --> 00:02:44,720 DR. CLARK. 65 00:02:44,720 --> 00:02:47,760 >>ALSO I'LL REACH OUT AND SEE 66 00:02:47,760 --> 00:02:51,400 IF WE CAN GET HIM. 67 00:02:51,400 --> 00:02:52,680 >>OKAY. 68 00:02:52,680 --> 00:02:55,400 DR. NANCY GONZALEZ. 69 00:02:55,400 --> 00:02:57,880 >>NANCY IS ALSO NOT ONLINE. 70 00:02:57,880 --> 00:03:00,120 I'LL REACH OUT TO HER. 71 00:03:00,120 --> 00:03:08,400 >>DR. CONSTANCE HORGAN. 72 00:03:08,400 --> 00:03:09,720 >>HI THERE. 73 00:03:09,720 --> 00:03:12,240 CONNIE HORGAN THE DIRECTOR OF 74 00:03:12,240 --> 00:03:12,960 THE INSTITUTE FOR BEHAVIORAL 75 00:03:12,960 --> 00:03:15,840 INSTITUTE AT THE HELLER SCHOOL 76 00:03:15,840 --> 00:03:16,680 AT BRANDEIS UNIVERSITY. 77 00:03:16,680 --> 00:03:18,840 I'M A HEALTH SERVICES RESEARCHER 78 00:03:18,840 --> 00:03:21,120 AND MY RESEARCH FOCUSES ON 79 00:03:21,120 --> 00:03:23,760 ALCOHOL SERVICES AND HOW TO 80 00:03:23,760 --> 00:03:24,840 BETTER INCORPORATE THE DELIVERY 81 00:03:24,840 --> 00:03:32,160 OF THOSE SERVICES. 82 00:03:32,160 --> 00:03:41,480 >>DR. RHONDA JONES-WEBB. 83 00:03:41,480 --> 00:03:52,000 >>I'LL REACH OUT TO HER ALSO. 84 00:03:53,000 --> 00:03:54,560 >>MS. BETH KANE-DAVIDSON. 85 00:03:54,560 --> 00:03:56,520 >>HOO HAPPY NEW YEAR. 86 00:03:56,520 --> 00:04:00,840 I'M THE DIRECTOR OF SUBURBAN 87 00:04:00,840 --> 00:04:02,680 HOSPITALS JOHNS HOPKINS 88 00:04:02,680 --> 00:04:05,000 TREATMENT CENTER AND DIRECT 89 00:04:05,000 --> 00:04:11,200 CAREER GIVER IN DEVELOPMENT OF 90 00:04:11,200 --> 00:04:12,360 PROGRAMS. 91 00:04:12,360 --> 00:04:14,400 >>DR. DAVID KERICKAN. 92 00:04:14,400 --> 00:04:18,080 >>PROFESSOR AND VICE CHAIR FOR 93 00:04:18,080 --> 00:04:20,960 RESEARCH AND NEUROLOGY AT THE 94 00:04:20,960 --> 00:04:22,600 INDIANA UNIVERSITY SCHOOL OF 95 00:04:22,600 --> 00:04:24,840 MEDICINE AND DIRECTOR OF THE 96 00:04:24,840 --> 00:04:27,280 ALCOHOL RESEARCH CENTER, 97 00:04:27,280 --> 00:04:28,360 CLINICAL NEUROPSYCHOLOGIST BY 98 00:04:28,360 --> 00:04:30,840 TRAINING AND MY RESEARCH USES 99 00:04:30,840 --> 00:04:33,960 FUNCTIONAL BRAIN IMAGING TO 100 00:04:33,960 --> 00:04:39,240 EXAMINE RISK IN YOUNG ADULTS. 101 00:04:39,240 --> 00:04:39,520 >>THANKS. 102 00:04:39,520 --> 00:04:49,800 DR. CHARLES LANG. 103 00:04:56,600 --> 00:05:00,120 >>I'M A PROFESSOR OF PSYCHIATRY 104 00:05:00,120 --> 00:05:02,840 AND PSYCHOLOGY AT THE UNIVERSITY 105 00:05:02,840 --> 00:05:04,040 OF WASHINGTON. 106 00:05:04,040 --> 00:05:06,800 MOST MY WORK IS ETIOLOGY AND 107 00:05:06,800 --> 00:05:09,000 PREVENTION FOR ALCOHOL USE 108 00:05:09,000 --> 00:05:10,680 DISORDERS AND RELATED COMORBID 109 00:05:10,680 --> 00:05:11,520 MENTAL HEALTH CONDITIONS 110 00:05:11,520 --> 00:05:12,080 PRIMARILY IN YOUNG ADULT 111 00:05:12,080 --> 00:05:13,920 POPULATIONS. 112 00:05:13,920 --> 00:05:15,720 >>THANKS, MARY. 113 00:05:15,720 --> 00:05:19,800 DR. MICHAEL LEWIS. 114 00:05:19,800 --> 00:05:23,960 >>I'M PROFESSOR OF PSYCHOLOGY 115 00:05:23,960 --> 00:05:28,240 IN THE DEPARTMENT PSYCHOLOGY AT 116 00:05:28,240 --> 00:05:29,640 THE GRADUATE CENTER. 117 00:05:29,640 --> 00:05:33,280 I'M A BEHAVIORAL NEURAL 118 00:05:33,280 --> 00:05:36,160 SCIENTIST AND INTERESTED IN 119 00:05:36,160 --> 00:05:37,000 REINFORCEMENT AND MECHANISMS 120 00:05:37,000 --> 00:05:39,840 INVOLVED WITH CONTROLLING 121 00:05:39,840 --> 00:05:40,600 INTAKE. 122 00:05:40,600 --> 00:05:41,960 I'M PARTICULARLY INTERESTED IN 123 00:05:41,960 --> 00:05:43,040 THE INTERACTION OF FOOD INTAKE 124 00:05:43,040 --> 00:05:50,840 AND NUTRITION AND ALCOHOL. 125 00:05:50,840 --> 00:05:56,160 >>THANKS. 126 00:05:56,160 --> 00:06:00,280 DR. LAURA NAGY. 127 00:06:00,280 --> 00:06:02,640 >>I'M INTERESTED IN 128 00:06:02,640 --> 00:06:03,400 [INDISCERNIBLE] CONTRIBUTIONS TO 129 00:06:03,400 --> 00:06:04,840 ALCOHOL ASSOCIATED LIVER 130 00:06:04,840 --> 00:06:05,080 DISEASE. 131 00:06:05,080 --> 00:06:08,680 >>THANKS, LAW ARE. 132 00:06:08,680 --> 00:06:10,720 -- THANKS, LAURA. 133 00:06:10,720 --> 00:06:11,800 >>DR. LAURA O'DELL. 134 00:06:11,800 --> 00:06:13,280 >>I'M THE SECOND LAURA. 135 00:06:13,280 --> 00:06:13,920 NICE TO SEE EVERYONE. 136 00:06:13,920 --> 00:06:15,600 I'M A PROFESSOR AT THE 137 00:06:15,600 --> 00:06:18,760 UNIVERSITY OF TEXAS AT EL PASO 138 00:06:18,760 --> 00:06:21,920 AND ASSOCIATE V.P. OF RESEARCH. 139 00:06:21,920 --> 00:06:24,680 MY RESEARCH FOCUSES ON RODENT 140 00:06:24,680 --> 00:06:26,440 MODELS TO STUDY NICOTINE USE IN 141 00:06:26,440 --> 00:06:27,640 VULNERABLE POPULATIONS. 142 00:06:27,640 --> 00:06:29,600 >>THANKS, LAURA. 143 00:06:29,600 --> 00:06:33,880 AND DR. SCOTT RUSSO. 144 00:06:33,880 --> 00:06:35,800 >>GEORGE, THANK YOU. 145 00:06:35,800 --> 00:06:37,720 I'M A PROFESSOR OF NEUROSCIENCE 146 00:06:37,720 --> 00:06:39,160 AT MOUNT SINAI AND DIRECTOR OF 147 00:06:39,160 --> 00:06:41,080 THE BRAIN AND BODY RESEARCH 148 00:06:41,080 --> 00:06:41,520 CENTER. 149 00:06:41,520 --> 00:06:44,000 THE MAJOR FOCUS OF MY WORK IS TO 150 00:06:44,000 --> 00:06:48,040 EXAMINE THE IMPACTS OF STRESSORS 151 00:06:48,040 --> 00:06:49,680 PARTICULARLY TRAUMATIC STRESS ON 152 00:06:49,680 --> 00:06:52,320 IMMUNE BRAIN INTERACTIONS AT 153 00:06:52,320 --> 00:06:54,000 PHYSICAL BORDERS WITHIN THE BODY 154 00:06:54,000 --> 00:07:04,520 AND IT'S RELATION TO DISEASE. 155 00:07:10,040 --> 00:07:11,680 >>DR. KATIE WITKIEWITZ. 156 00:07:11,680 --> 00:07:14,160 >>MY WORK IS FOCUSSED ON 157 00:07:14,160 --> 00:07:14,840 BEHAVIORAL TREATMENT FOR ALCOHOL 158 00:07:14,840 --> 00:07:17,000 USE DISORDER AND RECOVERY AND 159 00:07:17,000 --> 00:07:20,120 PRECISION MEDICINE APPROACHES 160 00:07:20,120 --> 00:07:22,240 AND UNDERSTANDING BETTER WHICH 161 00:07:22,240 --> 00:07:24,560 MEDICATION OR TREATMENTS WORK 162 00:07:24,560 --> 00:07:25,520 FOR INDIVIDUALS WITH ALCOHOL USE 163 00:07:25,520 --> 00:07:29,000 DISORDER. 164 00:07:29,000 --> 00:07:30,480 GREAT TO BE HERE. 165 00:07:30,480 --> 00:07:33,400 >>AND DR. CHARLES ARE YOU ON? 166 00:07:33,400 --> 00:07:34,640 >>HE'S NOT ON BUT DR. LANG HAS 167 00:07:34,640 --> 00:07:44,800 JOINED. 168 00:07:51,640 --> 00:07:52,560 HE HAS MUTED. 169 00:07:52,560 --> 00:08:03,040 >>CHARLES, CAN YOU UNMUTE. 170 00:08:51,680 --> 00:08:52,720 >>WE'LL CONTINUE. 171 00:08:52,720 --> 00:08:53,840 I'D LIKE YOU TO SHARE THOUGHTS 172 00:08:53,840 --> 00:08:57,000 AND EXPERIENCES AS TENURE AS 173 00:08:57,000 --> 00:09:00,080 COUNCIL MEMBERS AND MAYBE GIVE 174 00:09:00,080 --> 00:09:05,080 US THOUGHTS WHERE NIAAA SHOULD 175 00:09:05,080 --> 00:09:15,320 BE GOING -- 176 00:09:27,960 --> 00:09:30,520 >>WE NEED TO KEEP GOING FOR THE 177 00:09:30,520 --> 00:09:30,760 AGENDA. 178 00:09:30,760 --> 00:09:38,560 >>I'M THE DIRECTOR OF THE 179 00:09:38,560 --> 00:09:39,160 NATIONAL ADVISORY COUNCIL ON 180 00:09:39,160 --> 00:09:40,720 ALCOHOL AND ALCOHOLISM AND I'D 181 00:09:40,720 --> 00:09:42,000 LIKE TRISH AND VICKY AND BRIDGET 182 00:09:42,000 --> 00:09:46,120 TO INTRODUCE THEMSELVES AND I'LL 183 00:09:46,120 --> 00:09:48,400 TAKE IT FROM THERE TO ALERT THE 184 00:09:48,400 --> 00:09:52,120 OTHERS AND TRISH, VICKY AND 185 00:09:52,120 --> 00:09:52,600 BRIDGET. 186 00:09:52,600 --> 00:09:53,800 >>I'M THE DEPUTY DIRECTOR AT 187 00:09:53,800 --> 00:10:00,560 NIAAA. 188 00:10:00,560 --> 00:10:06,880 >>I'M VICKY BUCKLEY DEPUTY 189 00:10:06,880 --> 00:10:12,880 ETHICS COUNSELOR FOR NIAAA. 190 00:10:12,880 --> 00:10:16,560 >>HI, I'M BRIDGET WILLIAMS 191 00:10:16,560 --> 00:10:18,760 SIMMONS IN THE OFFICE SCIENCE 192 00:10:18,760 --> 00:10:20,160 POLICY AT NIAAA AND THE 193 00:10:20,160 --> 00:10:23,360 ASSOCIATE DIRECTOR FOR BASIC 194 00:10:23,360 --> 00:10:23,600 RESEARCH. 195 00:10:23,600 --> 00:10:24,160 THANK YOU. 196 00:10:24,160 --> 00:10:28,800 >>AND THEN DAVID GOLDMAN AND 197 00:10:28,800 --> 00:10:29,160 DAVID LOVINGER. 198 00:10:29,160 --> 00:10:30,880 >>I'M DAVID GOLDMAN THE 199 00:10:30,880 --> 00:10:33,640 CLINICAL DIRECTOR AND 200 00:10:33,640 --> 00:10:33,920 GENETICIST. 201 00:10:33,920 --> 00:10:41,680 I HAVE THE OF ORGANIZING THIS 202 00:10:41,680 --> 00:10:44,520 2022 BFC WITH AREAS TO WIC. 203 00:10:44,520 --> 00:10:47,520 >>I'M THE ACTING SCIENTIFIC 204 00:10:47,520 --> 00:10:53,000 DIRECTOR OF THE DIVISION OF 205 00:10:53,000 --> 00:10:54,920 INTRAMURAL AND BIOLOGICAL AND 206 00:10:54,920 --> 00:10:59,840 CLINICAL RESEARCH. 207 00:10:59,840 --> 00:11:00,480 HELLO. 208 00:11:00,480 --> 00:11:07,440 >>YOU'LL HEAR A LOT ABOUT 209 00:11:07,440 --> 00:11:07,800 DAVID. 210 00:11:07,800 --> 00:11:10,480 >>PHILIPPE WOULD YOU LIKE TO 211 00:11:10,480 --> 00:11:12,880 INTRODUCE YOURSELF AND YOUR 212 00:11:12,880 --> 00:11:15,680 POSITION. 213 00:11:15,680 --> 00:11:16,680 >>I'M THE ACTING DIRECTOR OF 214 00:11:16,680 --> 00:11:22,080 EXTRAMURAL ACTIVITIES AT NIAAA. 215 00:11:22,080 --> 00:11:27,840 >>I'M THE ACTING EXECUTIVE 216 00:11:27,840 --> 00:11:30,320 SECRETARY FOR NC NATION COUNCIL 217 00:11:30,320 --> 00:11:33,000 OF ALCOHOLISM AND ABUSE AND 218 00:11:33,000 --> 00:11:43,520 CHIEF OF THE PLANT AT THE NIAAA. 219 00:11:45,400 --> 00:11:48,080 >>HELLO, I'M CATHY YOUNG. 220 00:11:48,080 --> 00:11:49,480 I'M THE DIRECTOR OF THE DIVISION 221 00:11:49,480 --> 00:11:52,720 OF METABOLISM AND HEALTH EFFECTS 222 00:11:52,720 --> 00:11:56,840 AT NIAAA THE DIVISION THAT 223 00:11:56,840 --> 00:12:01,040 OVERSEES ALCOHOL ORGAN DAMAGE. 224 00:12:01,040 --> 00:12:06,160 >>I'M AND THE -- I'M THE 225 00:12:06,160 --> 00:12:07,800 DIRECTOR OF NEUROSCIENCE AND 226 00:12:07,800 --> 00:12:08,080 BEHAVIOR. 227 00:12:08,080 --> 00:12:09,240 WE DO A LOT OF STUFF ALSO IN 228 00:12:09,240 --> 00:12:12,480 TERMS OF GENETICS, GENOMICS AND 229 00:12:12,480 --> 00:12:12,880 THE LIKE. 230 00:12:12,880 --> 00:12:17,960 WELCOME TO EVERYONE. 231 00:12:17,960 --> 00:12:18,840 >>HELLO. 232 00:12:18,840 --> 00:12:21,000 I'M RAY LITTON, DIRECTOR OF THE 233 00:12:21,000 --> 00:12:24,880 DIVISION OF TREATMENT AND 234 00:12:24,880 --> 00:12:32,960 RECOVERY. 235 00:12:32,960 --> 00:12:35,680 >>I'M THE DIRECTOR EPIDEMIOLOGY 236 00:12:35,680 --> 00:12:36,880 AND RESEARCH AT NIAAA. 237 00:12:36,880 --> 00:12:47,040 >>PONG 238 00:12:47,440 --> 00:12:47,440 >> 239 00:12:47,880 --> 00:12:49,680 >>NOBODY HAS SIGNED ON AND WE 240 00:12:49,680 --> 00:12:51,640 CAN PROBABLY INTRODUCE THEM 241 00:12:51,640 --> 00:12:53,880 DURING THE LATER SPOT OF THE DAY 242 00:12:53,880 --> 00:12:57,000 WHEN WE HAVE RETIRING MEMBERS 243 00:12:57,000 --> 00:13:01,320 TALK. 244 00:13:01,320 --> 00:13:02,720 >>SO WHAT ARE WHERE HE MOVING 245 00:13:02,720 --> 00:13:03,760 TO NEXT THEN? 246 00:13:03,760 --> 00:13:06,560 >>NOW WE'RE GOING START WITH 247 00:13:06,560 --> 00:13:06,840 YOUR REPORT. 248 00:13:06,840 --> 00:13:08,960 >>OKAY. 249 00:13:08,960 --> 00:13:10,680 WE'LL DO THE RETIREMENT -- SO 250 00:13:10,680 --> 00:13:11,920 HAVE YOU PLENTY OF TIME TO THINK 251 00:13:11,920 --> 00:13:13,440 ABOUT WHAT I ASKED EARLIER THE 252 00:13:13,440 --> 00:13:16,120 THREE OF YOU THAT ARE RETIRING 253 00:13:16,120 --> 00:13:18,200 AND WE'LL CATCH YOU AFTER MY 254 00:13:18,200 --> 00:13:19,680 DIRECTOR'S REPORT. 255 00:13:19,680 --> 00:13:26,200 WE'LL MOVE TO THE DIRECTOR'S 256 00:13:26,200 --> 00:13:26,440 REPORT. 257 00:13:26,440 --> 00:13:27,520 EVERYTHING WITH SOUND AND 258 00:13:27,520 --> 00:13:28,280 HEARING AND SLIDES? 259 00:13:28,280 --> 00:13:31,000 >>YES, SLIDES ARE FINE. 260 00:13:31,000 --> 00:13:32,480 SOUND IS GREAT. 261 00:13:32,480 --> 00:13:35,440 >>SO THIS IS MY REPORT ON 262 00:13:35,440 --> 00:13:37,640 INSTITUTE ACTIVITIES FOR THE 263 00:13:37,640 --> 00:13:41,000 162nd MEETING OF THE NATIONAL 264 00:13:41,000 --> 00:13:41,640 ADVISORY COUNCIL ON ALCOHOL AND 265 00:13:41,640 --> 00:13:42,880 ALCOHO 266 00:13:42,880 --> 00:13:45,560 ALCOHOLISM. 267 00:13:45,560 --> 00:13:47,680 SO EVERYBODY WANTS TO KNOW ABOUT 268 00:13:47,680 --> 00:13:48,880 THE BUDGET. 269 00:13:48,880 --> 00:13:50,880 ON DECEMBER 29, 2022 THE 270 00:13:50,880 --> 00:13:53,000 PRESIDENT SIGNED THE 271 00:13:53,000 --> 00:13:54,880 CONSOLIDATED APPROPRIATIONS ACT 272 00:13:54,880 --> 00:13:56,080 OF 2023. 273 00:13:56,080 --> 00:14:02,080 NIH RECEIVED A TOTAL OF $47.7 274 00:14:02,080 --> 00:14:02,280 BILLION. 275 00:14:02,280 --> 00:14:06,920 $2.5 BILLION OR 5.5% INCREASE 276 00:14:06,920 --> 00:14:11,000 ABOVE FISCAL YEAR 2022 ENACTED 277 00:14:11,000 --> 00:14:11,840 LIVELY. 278 00:14:11,840 --> 00:14:16,360 NIAAA RECEIVED $95.3 MILLION. 279 00:14:16,360 --> 00:14:17,960 THIS REPRESENTS AN APPROXIMATELY 280 00:14:17,960 --> 00:14:20,760 $22 MILLION OR 3.8% INCREASE 281 00:14:20,760 --> 00:14:22,920 OVER FISCAL YEAR 2022. 282 00:14:22,920 --> 00:14:27,040 WE ESTIMATE WE'RE GOING TO BE 283 00:14:27,040 --> 00:14:28,720 SUPPORTING ABOUT 728 RESEARCH 284 00:14:28,720 --> 00:14:30,880 PROJECT GRANTS THIS FISCAL YEAR. 285 00:14:30,880 --> 00:14:33,280 THE APPROPRIATION OF THE FISCAL 286 00:14:33,280 --> 00:14:37,080 YEAR 2024 PRESIDENT'S BUDGET IS 287 00:14:37,080 --> 00:14:38,280 UNDERWAY. 288 00:14:38,280 --> 00:14:44,120 THAT'S BASICALLY ALL WE HAVE TO 289 00:14:44,120 --> 00:14:46,640 REPORT ON THE BUDGET. 290 00:14:46,640 --> 00:14:48,200 AS YOU KNOW THERE'S THE 291 00:14:48,200 --> 00:14:49,400 PRESIDENT'S BUDGET, HOUSE'S 292 00:14:49,400 --> 00:14:51,560 BUDGET AND SENATE'S BUDGET AND 293 00:14:51,560 --> 00:14:52,520 THEY'LL ULTIMATELY COME TOGETHER 294 00:14:52,520 --> 00:15:03,040 TO BE OUR FINAL BUDGET FOR 2024. 295 00:15:22,000 --> 00:15:26,200 AND HAD SPECIAL EMPHASIS PANELS 296 00:15:26,200 --> 00:15:29,400 AND ALL GRANT MANAGEMENT 297 00:15:29,400 --> 00:15:29,680 ACTIVITIES. 298 00:15:29,680 --> 00:15:32,080 ABE ACTED AS THE EXECUTIVE 299 00:15:32,080 --> 00:15:34,400 SECRETARY OF NIAAA AND 300 00:15:34,400 --> 00:15:35,840 RESPONSIBLE FOR OVERSEEING 301 00:15:35,840 --> 00:15:38,000 COMMITTEE MANAGEMENT ACTIVITIES 302 00:15:38,000 --> 00:15:41,000 INCLUDING FEDERAL ADVISORY 303 00:15:41,000 --> 00:15:42,040 COMMITTEES. 304 00:15:42,040 --> 00:15:43,200 IN HIS RETIREMENT ABE SAID HE 305 00:15:43,200 --> 00:15:45,680 LOOKED FORWARD TO EXPANDING HIS 306 00:15:45,680 --> 00:15:46,720 TRAVELS AND FINDING OTHER 307 00:15:46,720 --> 00:15:48,920 EXCITING WAYS TO FILL HIS DAYS. 308 00:15:48,920 --> 00:15:52,960 HE'LL BE VERY MISSED VERY MUCH 309 00:15:52,960 --> 00:15:53,720 SO. 310 00:15:53,720 --> 00:15:57,240 AS YOU KNOW, PHILIPPE HAS STEP 311 00:15:57,240 --> 00:16:00,000 YOU TO BE ACTING OEA DIRECTOR 312 00:16:00,000 --> 00:16:08,880 AND WE'LL BEGIN A SEARCH FOR A 313 00:16:08,880 --> 00:16:09,440 PERMANENT APPOINTEE TO THE 314 00:16:09,440 --> 00:16:17,000 POSITION IN THE NEAR FUTURE. 315 00:16:17,000 --> 00:16:24,440 THERE'S A RUMOR THAT HE MAY 316 00:16:24,440 --> 00:16:27,600 APPEAR AT A MEETING FROM TIME TO 317 00:16:27,600 --> 00:16:27,800 TIME. 318 00:16:27,800 --> 00:16:30,000 IF YOU MISS HIM LIKE I DO 319 00:16:30,000 --> 00:16:32,120 ESPECIALLY IF THE MEETING IS 320 00:16:32,120 --> 00:16:33,960 HELD IN LOUISIANA. 321 00:16:33,960 --> 00:16:35,840 THAT MAY BE A DRAWING POINT FOR 322 00:16:35,840 --> 00:16:37,600 ABE AND HE'S DONE A GREAT JOB 323 00:16:37,600 --> 00:16:41,200 FOR NIAAA AND HONOR AND 324 00:16:41,200 --> 00:16:43,520 APPRECIATE HIM. 325 00:16:43,520 --> 00:16:46,000 AS I SAID WE'RE IN THE EARLY 326 00:16:46,000 --> 00:16:47,840 STAGES OF THE RECRUITMENT 327 00:16:47,840 --> 00:16:48,960 PROCESS AND ANTICIPATE 328 00:16:48,960 --> 00:16:50,400 COMPLETING THE PROCESS IN THE 329 00:16:50,400 --> 00:16:51,760 NEXT FEW MONTHS FOR DIRECTOR OF 330 00:16:51,760 --> 00:16:53,200 THE OFFICE OF EXTRAMURAL 331 00:16:53,200 --> 00:16:54,120 ACTIVITIES. 332 00:16:54,120 --> 00:16:56,320 AS I ALREADY EXPLAINED TO YOU 333 00:16:56,320 --> 00:16:59,960 ALL IN THE CLOSED SESSION, WE 334 00:16:59,960 --> 00:17:02,440 ARE IN THE PROCESS OF RECRUITING 335 00:17:02,440 --> 00:17:09,000 A SCIENTIFIC DIRECTOR FOR OUR 336 00:17:09,000 --> 00:17:10,160 INTRAMURAL RESEARCH PROGRAM AND 337 00:17:10,160 --> 00:17:12,520 EACH CANDIDATE HAS GIVEN A TALK 338 00:17:12,520 --> 00:17:16,760 ABOUT THEIR RESEARCH AS WELL AS 339 00:17:16,760 --> 00:17:19,160 THE VISION FOR THE INTRAMURAL 340 00:17:19,160 --> 00:17:20,440 PROGRAM WE SOLICITED FEEDBACK 341 00:17:20,440 --> 00:17:22,880 FROM ALL OF STAFF AND AFTER A 342 00:17:22,880 --> 00:17:24,480 FINAL INTERVIEW STAGE WE HOPE TO 343 00:17:24,480 --> 00:17:26,080 MAKE A SELECTION IN THE NEXT FEW 344 00:17:26,080 --> 00:17:26,440 WEEKS. 345 00:17:26,440 --> 00:17:32,960 AND THEN WE WERE ALSO RECRUITING 346 00:17:32,960 --> 00:17:35,240 A SCIENTIFIC DIVERSITY OFFICER 347 00:17:35,240 --> 00:17:36,760 AND RECRUITING FOR THIS POSITION 348 00:17:36,760 --> 00:17:38,400 AND ANTICIPATE THE OFFICIAL 349 00:17:38,400 --> 00:17:39,800 ANNOUNCEMENT WILL OPEN IN THE 350 00:17:39,800 --> 00:17:40,280 NEXT FEW WEEKS. 351 00:17:40,280 --> 00:17:42,920 WE WELCOME YOUR HELP IN ALL OF 352 00:17:42,920 --> 00:17:44,840 THESE RECRUITMENTS. 353 00:17:44,840 --> 00:17:48,920 IF YOU FEEL LIKE THERE'S A 354 00:17:48,920 --> 00:17:51,000 CANDIDATE THAT WOULD MATCH THE 355 00:17:51,000 --> 00:17:56,560 JOB ANNOUNCEMENT, PLEASE SEND 356 00:17:56,560 --> 00:17:58,680 THE INFORMATION TO THEM. 357 00:17:58,680 --> 00:18:01,040 YOU ARE, AGAIN AS COUNCIL 358 00:18:01,040 --> 00:18:02,640 MEMBERS ARE AMBASSADORS TO THE 359 00:18:02,640 --> 00:18:05,080 REAL WORLD, HELP US OUT WITH 360 00:18:05,080 --> 00:18:11,040 THIS IF YOU CAN. 361 00:18:11,040 --> 00:18:12,560 THERE'S A NUMBER OF FUNDING 362 00:18:12,560 --> 00:18:13,480 OPPORTUNITIES YOU CAN LOOK IN 363 00:18:13,480 --> 00:18:15,520 THE DIRECTOR'S REPORT FOR A 364 00:18:15,520 --> 00:18:16,520 COMPLETE LISTING. 365 00:18:16,520 --> 00:18:17,880 I'LL HIGHLIGHT A FEW RESEARCH 366 00:18:17,880 --> 00:18:20,200 OPPORTUNITIES FOR NEW AND 367 00:18:20,200 --> 00:18:24,880 AT-RISK INVESTIGATORS TO PROMOTE 368 00:18:24,880 --> 00:18:26,960 WORKFORCE DIVERSITY, WE'RE 369 00:18:26,960 --> 00:18:28,880 PARTICIPATING A FUNDING 370 00:18:28,880 --> 00:18:29,640 OPPORTUNITY ANNOUNCEMENT TO 371 00:18:29,640 --> 00:18:31,200 SUPPORT RO1 GRANT APPLICATIONS 372 00:18:31,200 --> 00:18:33,680 FROM NEW INVESTIGATORS AND 373 00:18:33,680 --> 00:18:36,920 AT-RISK INVESTIGATORS FROM 374 00:18:36,920 --> 00:18:39,280 DIVERSE BACKGROUNDS INCLUDE 375 00:18:39,280 --> 00:18:43,680 THOSE IN THE HEALTH-RELATED 376 00:18:43,680 --> 00:18:43,960 SCIENCES. 377 00:18:43,960 --> 00:18:49,200 HERE'S THE CONTACT. 378 00:18:49,200 --> 00:18:51,680 I WANTED TO MENTION NIH DATA 379 00:18:51,680 --> 00:18:53,040 MANAGEMENT AND SHARING POLICY IS 380 00:18:53,040 --> 00:18:54,280 IN EFFECT. 381 00:18:54,280 --> 00:18:59,880 ALL OF YOU WHO HAVE GRANTS FROM 382 00:18:59,880 --> 00:19:02,960 NIAAA ABOUT THIS AND THE FINAL 383 00:19:02,960 --> 00:19:05,000 NIH POLICY AND SHARING WENT INTO 384 00:19:05,000 --> 00:19:06,360 EFFECT. 385 00:19:06,360 --> 00:19:10,280 THE POLICY PROMOTES TRANSPARENCY 386 00:19:10,280 --> 00:19:11,640 AND ACCOUNTABILITY BY SETTING A 387 00:19:11,640 --> 00:19:12,640 MINIMUM SET OF EXPECTATIONS FOR 388 00:19:12,640 --> 00:19:21,000 DATA MANAGEMENT AND SHARING. 389 00:19:21,000 --> 00:19:22,640 THE DATA SHOULD BE SHARED NO 390 00:19:22,640 --> 00:19:28,480 LATER THAN THE TIME OF AN 391 00:19:28,480 --> 00:19:33,080 ASSOCIATED PUBLICATION OR END OF 392 00:19:33,080 --> 00:19:43,360 THE AWARD PERIOD. 393 00:20:18,360 --> 00:20:24,720 IT'S A GREAT IDEA TO AFFECT AND 394 00:20:24,720 --> 00:20:30,560 SPAWNING INTO OUR CONSORTIA A 395 00:20:30,560 --> 00:20:36,800 GREAT DEAL OF INTEREST AND DATA 396 00:20:36,800 --> 00:20:42,320 MINING AND HARMONIZING AND 397 00:20:42,320 --> 00:20:42,880 UTILIZE AND CAPITALIZE ON 398 00:20:42,880 --> 00:20:53,200 COORDINATED EFFORTS. 399 00:21:26,000 --> 00:21:27,000 AND THE DIRECTOR OF THE NATIONAL 400 00:21:27,000 --> 00:21:30,360 INSTITUTE ON DRUG ABUSE, 401 00:21:30,360 --> 00:21:32,480 DR. NORA VOLKOW AND THE DIRECTOR 402 00:21:32,480 --> 00:21:34,040 OF THE NATIONAL INSTITUTE ON 403 00:21:34,040 --> 00:21:35,080 MENTAL HEALTH DR. JOSH GORDON. 404 00:21:35,080 --> 00:21:36,920 IN ADDITION TO HIGHLIGHTS THE 405 00:21:36,920 --> 00:21:39,240 IMPORTANCE OF REDUCING STIGMA 406 00:21:39,240 --> 00:21:41,680 AND OTHER HEALTH BARRIERS, A 407 00:21:41,680 --> 00:21:42,440 CONFERENCE FEATURED PANEL 408 00:21:42,440 --> 00:21:44,840 SESSIONS COVERING A WIDE RANGE 409 00:21:44,840 --> 00:21:47,520 OF TOPICS INCLUDING OVERVIEW OF 410 00:21:47,520 --> 00:21:48,680 HARMFUL ALCOHOL AND OTHER 411 00:21:48,680 --> 00:21:50,680 SUBSTANCE USE IN WOMEN AND 412 00:21:50,680 --> 00:21:52,560 ADOLESCENT GIRLS, MODEL PROGRAMS 413 00:21:52,560 --> 00:21:53,720 FOR MOTHERS WITH ALCOHOL USE 414 00:21:53,720 --> 00:21:55,320 DISORDER AND OTHER SUBSTANCE USE 415 00:21:55,320 --> 00:22:00,440 DISORDER AND CHILDREN WITH 416 00:22:00,440 --> 00:22:06,480 PRENATE SUBSTANCE DISORDER. 417 00:22:06,480 --> 00:22:12,080 WE ALSO HAD A FORUM ON COVID-19 418 00:22:12,080 --> 00:22:12,400 RESEARCH. 419 00:22:12,400 --> 00:22:15,360 LAST MONTH WE HAD A FORUM WITH 420 00:22:15,360 --> 00:22:16,880 NIAAA SUPPORTED GRANTEES 421 00:22:16,880 --> 00:22:17,440 CONDUCTING COVID-RELATED 422 00:22:17,440 --> 00:22:27,600 RESEARCH. 423 00:22:56,640 --> 00:23:01,200 AND IMPACTS OF COVID-19 STRESS 424 00:23:01,200 --> 00:23:03,920 ON ALCOHOL CONSUMPTION AND NEURO 425 00:23:03,920 --> 00:23:05,600 VULNERABLES AND AFFECTS OF 426 00:23:05,600 --> 00:23:07,320 COVID-19 AND ALCOHOL RELATED 427 00:23:07,320 --> 00:23:08,840 OUTCOMES AND HIV/AIDS AND OTHER 428 00:23:08,840 --> 00:23:11,680 FACTORS AND HEALTH SERVICES. 429 00:23:11,680 --> 00:23:14,840 ONE OF THE -- THERE WERE MANY 430 00:23:14,840 --> 00:23:16,760 THINGS THAT CAME OUT OF THIS, 431 00:23:16,760 --> 00:23:21,840 SOME NEW AND SOME POTENTIALLY 432 00:23:21,840 --> 00:23:22,280 INTERESTING. 433 00:23:22,280 --> 00:23:24,480 AND MANY WORKS IN PROGRESS. 434 00:23:24,480 --> 00:23:27,920 WE LOOK FORWARD TO AN UPDATE IN 435 00:23:27,920 --> 00:23:30,080 A YEAR OR TWO ON FURTHER 436 00:23:30,080 --> 00:23:40,520 PROGRESS IN THIS DOMAIN. 437 00:23:49,400 --> 00:23:51,000 YOU'LL REMEMBER WE PUBLISHED A 438 00:23:51,000 --> 00:23:54,080 PAPER SHOWING THERE WAS A 25% 439 00:23:54,080 --> 00:24:00,400 INCREASE IN ALCOHOL-RELATED 440 00:24:00,400 --> 00:24:02,600 DEATHS IN THE FIRST YEAR OF THE 441 00:24:02,600 --> 00:24:05,000 PANDEMIC. 442 00:24:05,000 --> 00:24:06,920 THAT HAS BEEN SUSTAINED IN THE 443 00:24:06,920 --> 00:24:08,960 SECOND YEAR AND INCREASED A BIT 444 00:24:08,960 --> 00:24:19,120 FURTHER. 445 00:24:24,920 --> 00:24:28,400 AND THE FACTOR JUMPED FROM 2019 446 00:24:28,400 --> 00:24:32,440 AND ANOTHER PERCENT IN 2021. 447 00:24:32,440 --> 00:24:33,400 WE'LL BE FOLLOWING THIS AS 448 00:24:33,400 --> 00:24:39,080 ALWAYS IT POINTS TO THE FACT 449 00:24:39,080 --> 00:24:49,600 THAT WE BELIEVE AND WE CAN SHINE 450 00:24:53,200 --> 00:24:55,520 A LIGHT ON SUBSET OF DRINKING 451 00:24:55,520 --> 00:25:00,760 WHICH IS DRINK TO COPE WITH 452 00:25:00,760 --> 00:25:11,200 STRESS AND TRAUMA TO SOCIETY 453 00:25:11,200 --> 00:25:12,520 THERE'LL BE A TAIL ASSOCIATED 454 00:25:12,520 --> 00:25:13,920 WITH THE PANDEMIC THAT MAY GO ON 455 00:25:13,920 --> 00:25:15,040 FOR SOME TIME. 456 00:25:15,040 --> 00:25:18,520 ONE OF OUR EFFORTS AT NIAAA IS 457 00:25:18,520 --> 00:25:20,640 TO BE PREPARED FOR HELPING 458 00:25:20,640 --> 00:25:22,760 PEOPLE AS BEST WE CAN IN THE 459 00:25:22,760 --> 00:25:28,800 POST-PANDEMIC PERIOD. 460 00:25:28,800 --> 00:25:31,480 THIS HAS BEEN FUN, I HAVE TO 461 00:25:31,480 --> 00:25:31,640 SAY. 462 00:25:31,640 --> 00:25:34,200 THERE'S PROBABLY A COUPLE PEOPLE 463 00:25:34,200 --> 00:25:35,720 AT NIAAA THAT CAN'T IMAGINE THIS 464 00:25:35,720 --> 00:25:38,640 WAS FUN BUT WE PARTICIPATED IN 465 00:25:38,640 --> 00:25:41,080 MORE THAN 60 -- NOT KIDDING, 466 00:25:41,080 --> 00:25:44,080 MEETING, INTERVIEWS IN JANUARY 467 00:25:44,080 --> 00:25:47,520 AND SATELLITE MEDIA TOUR WHICH 468 00:25:47,520 --> 00:25:50,720 DISCUSSED BEHAVIORS DURING THE 469 00:25:50,720 --> 00:25:52,720 HOLIDAYS THAT MAY SHOW SIGNS OF 470 00:25:52,720 --> 00:25:54,720 PROBLEMS WITH ALCOHOL AND DRY 471 00:25:54,720 --> 00:25:55,560 JANUARY. 472 00:25:55,560 --> 00:25:57,480 THE SATELLITE MEDIA TOUR WHICH I 473 00:25:57,480 --> 00:25:58,920 DID INCLUDED 17 OUTLETS AND A 474 00:25:58,920 --> 00:26:09,400 REACH OF 1.8 MILLION PEOPLE. 475 00:26:16,120 --> 00:26:18,880 IT FAILED TO REFLECT A CULTURE 476 00:26:18,880 --> 00:26:19,120 CHANGE. 477 00:26:19,120 --> 00:26:25,400 A GREAT DEAL MORE INTEREST IN 478 00:26:25,400 --> 00:26:27,960 HEALTHY LIFE STYLES AND PERHAPS 479 00:26:27,960 --> 00:26:29,320 THE ROLE OF ALCOHOL IN NOT SO 480 00:26:29,320 --> 00:26:35,360 HEALTHY LIFESTYLE. 481 00:26:35,360 --> 00:26:36,400 THIS IS SOMETHING WE'RE 482 00:26:36,400 --> 00:26:39,480 UTILIZING IN SOME WAYS TO GET 483 00:26:39,480 --> 00:26:42,640 THE WORD OUT ABOUT SOME OF THE 484 00:26:42,640 --> 00:26:45,000 PROBLEMS ASSOCIATED WITH 485 00:26:45,000 --> 00:26:50,680 UNHEALTHY DRINKING. 486 00:26:50,680 --> 00:26:54,440 MOST OF YOU ARE AWARE OF THE 487 00:26:54,440 --> 00:26:55,240 PROFESSIONAL CORPS RESEARCH ON 488 00:26:55,240 --> 00:26:57,400 ALCOHOL AND WE HAD A COUNCIL ON 489 00:26:57,400 --> 00:26:58,120 THIS. 490 00:26:58,120 --> 00:27:08,640 WE CONTINUE TO PROMOTE THE HPCR. 491 00:27:20,400 --> 00:27:22,680 THERE'S RECOMMENDED EDUCATIONAL 492 00:27:22,680 --> 00:27:22,960 ACTIVITY. 493 00:27:22,960 --> 00:27:28,960 AND DESIGNATED BY THE AMERICAN 494 00:27:28,960 --> 00:27:35,520 BOARD OF ADDICTION MEDICINE WE 495 00:27:35,520 --> 00:27:37,000 HOSTED A WEBINAR IN DECEMBER 496 00:27:37,000 --> 00:27:39,960 2022 THAT INCLUDED A DISCUSSION 497 00:27:39,960 --> 00:27:45,760 ABOUT HOW THE HPCR AND SUPPORT 498 00:27:45,760 --> 00:27:48,720 PEOPLE IN RECOVERY AND OTHER 499 00:27:48,720 --> 00:27:49,720 COLLABORATORS HAVE REALLY DONE A 500 00:27:49,720 --> 00:27:57,280 GREAT JOB IN THIS WEBINAR. 501 00:27:57,280 --> 00:27:58,680 I'LL URGE YOU AS I URGED YOU 502 00:27:58,680 --> 00:28:00,680 BEFORE TO PASS THE WORD. 503 00:28:00,680 --> 00:28:03,160 I DON'T CARE WHETHER YOU DO 504 00:28:03,160 --> 00:28:09,320 APPLIED OR CLINICAL RESEARCH OR 505 00:28:09,320 --> 00:28:09,960 BASIC RESEARCH THERE'S 506 00:28:09,960 --> 00:28:11,280 INFORMATION FOR EVERYONE AND 507 00:28:11,280 --> 00:28:14,800 GREAT FOR TEACHING IN ACADEMIC 508 00:28:14,800 --> 00:28:15,160 ENVIRONMENTS. 509 00:28:15,160 --> 00:28:16,720 THERE'S A LOT OF RESOURCES AND 510 00:28:16,720 --> 00:28:19,480 REFERSES YOU CAN USE FOR 511 00:28:19,480 --> 00:28:20,360 TEACHING AND GENERATING SLIDES 512 00:28:20,360 --> 00:28:22,960 FOR ANY TALKS YOU WANT TO GIVE. 513 00:28:22,960 --> 00:28:27,480 WE AIM FOR PRIMARY CARE DOCTORS 514 00:28:27,480 --> 00:28:30,920 BUT I FEEL THE HPCR CAN BE 515 00:28:30,920 --> 00:28:33,960 USEFUL FOR ALL THE PUBLIC THAT 516 00:28:33,960 --> 00:28:37,120 ARE INTERESTED AN HAVE QUESTIONS 517 00:28:37,120 --> 00:28:47,360 ABOUT ALCOHOL. 518 00:28:49,200 --> 00:28:51,320 I WANT TO TALK ABOUT RESEARCH 519 00:28:51,320 --> 00:28:52,680 HIGHLIGHTS AND THE FIRST IS 520 00:28:52,680 --> 00:28:53,360 NARCISSISTIC SO WE'LL GO TO THE 521 00:28:53,360 --> 00:29:03,560 NEXT SLIDE. 522 00:29:08,800 --> 00:29:10,440 THE STAFF SCIENTIST IN THE 523 00:29:10,440 --> 00:29:12,280 LONGEST NAMED LABORATORY IN THE 524 00:29:12,280 --> 00:29:13,600 HISTORY OF THE INTRAMURAL 525 00:29:13,600 --> 00:29:16,960 PROGRAM THE CLINICAL, PSYCHO 526 00:29:16,960 --> 00:29:20,720 NEURAL NEUROCLINOLOGY SECTION 527 00:29:20,720 --> 00:29:25,240 AND IT'S A JOINT SECTION BETWEEN 528 00:29:25,240 --> 00:29:26,280 NIDA AND NIAAA. 529 00:29:26,280 --> 00:29:28,360 MY LABORATORY AT NIDA ALSO 530 00:29:28,360 --> 00:29:32,240 PARTICIPATED IN THIS STUDY FOR 531 00:29:32,240 --> 00:29:33,000 FULL DISCLOSURE. 532 00:29:33,000 --> 00:29:37,480 WE NOTICED IN THE PAST COUPLE OF 533 00:29:37,480 --> 00:29:42,920 YEARS THAT CERTAINLY THERE'S A 534 00:29:42,920 --> 00:29:45,200 ROLE IN ALCOHOL USE DISORDER. 535 00:29:45,200 --> 00:29:55,760 OUR FOCUS HAS BEEN ON CORTICOID 536 00:29:57,040 --> 00:30:07,440 RECEPTOR AND RECEPTOR AND 537 00:30:13,800 --> 00:30:15,920 THERE'S A RESPONSE IN BLOOD 538 00:30:15,920 --> 00:30:17,800 PRESSURE AND THE ALCOHOL USE 539 00:30:17,800 --> 00:30:19,720 DISORDER DATA CAME FROM MONKEYS 540 00:30:19,720 --> 00:30:23,680 AND RODENTS SHOWING THERE WAS AN 541 00:30:23,680 --> 00:30:29,000 INTERESTING DECREASE -- INCREASE 542 00:30:29,000 --> 00:30:36,240 IN ALDOSTERONE THAT CORRELATED 543 00:30:36,240 --> 00:30:40,480 WITH CRAVING AND ANXIETY AND A 544 00:30:40,480 --> 00:30:45,600 STAFF SCIENTIST NOTED THAT THERE 545 00:30:45,600 --> 00:30:56,160 IS AN FDA MINERAL CORTICOID AND 546 00:30:59,760 --> 00:31:05,000 WE EMBARKED ON PRECLINICAL 547 00:31:05,000 --> 00:31:14,680 STUDIES. 548 00:31:14,680 --> 00:31:23,920 AND A RECEPTOR CORTICOID COULD 549 00:31:23,920 --> 00:31:25,920 HELP IN ALCOHOL USE DISORDER AND 550 00:31:25,920 --> 00:31:32,360 IN RODENT INDEPENDENT AND 551 00:31:32,360 --> 00:31:33,720 NON-DEPENDENT ANIMALS IT 552 00:31:33,720 --> 00:31:41,000 ADDRESSED ALCOHOL AND ALCOHOL 553 00:31:41,000 --> 00:31:47,560 INTAKE. 554 00:31:47,560 --> 00:31:53,000 WE SAW THIS IN ANOTHER MOUSE 555 00:31:53,000 --> 00:31:57,040 MODEL DRINKING IN THE DARK AND 556 00:31:57,040 --> 00:32:00,960 SEEMS TO BE SELECTIVE FOR 557 00:32:00,960 --> 00:32:07,480 ALCOHOL. 558 00:32:07,480 --> 00:32:09,480 THIS IS MORE FASCINATING BECAUSE 559 00:32:09,480 --> 00:32:10,680 I'M A BASIC RESEARCHER AND THIS 560 00:32:10,680 --> 00:32:16,200 IS A CLINICAL STUDY. 561 00:32:16,200 --> 00:32:26,680 AND WE DID WE'RE CALLING A 562 00:32:27,320 --> 00:32:30,840 PHARMACOEPIDEMIOLOGY STUDY AND 563 00:32:30,840 --> 00:32:35,560 THEY IDENTIFIED A POSITIVE 564 00:32:35,560 --> 00:32:36,960 INTERACTION WITH THIS AND 565 00:32:36,960 --> 00:32:41,000 U.S. U.S. DEPARTMENT OF VETERANS 566 00:32:41,000 --> 00:32:45,000 AFFAIRS ELECTRONIC HEALTH RECORD 567 00:32:45,000 --> 00:32:48,920 DATA THEY FOUND PEOPLE EXPOSED 568 00:32:48,920 --> 00:32:53,560 AND 34,000 UNMATCHED CONTROL AND 569 00:32:53,560 --> 00:32:54,960 NOTICE THE CHANGE IN SCORES AT 570 00:32:54,960 --> 00:32:56,720 BASELINE AND FOLLOW-UP AND THERE 571 00:32:56,720 --> 00:32:59,720 WAS A GREATER DECREASE IN 572 00:32:59,720 --> 00:33:04,000 INDIVIDUALS IN AUDIT C SCORES 573 00:33:04,000 --> 00:33:14,400 AND THOSE EXPOSED TO 574 00:33:22,120 --> 00:33:24,920 SPIRONOLACTONE AND THE DOSE 575 00:33:24,920 --> 00:33:27,360 WHICH STARTED AT 50 MILLIGRAMS 576 00:33:27,360 --> 00:33:36,560 PER DAY BUT THE LARGER DOSE 577 00:33:36,560 --> 00:33:47,080 PRODUCED A LOT BIGGER EFFECT. 578 00:34:05,040 --> 00:34:07,600 THIS IS NOT A CLASSIC CLINICAL 579 00:34:07,600 --> 00:34:12,200 TRIAL BUT CAN LEAD AND GENERATE 580 00:34:12,200 --> 00:34:14,360 HYPOTHESES FOR ULTIMATE CLINICAL 581 00:34:14,360 --> 00:34:14,640 TRIALS. 582 00:34:14,640 --> 00:34:17,000 I THINK YOU'LL SEE MORE ACTIVITY 583 00:34:17,000 --> 00:34:18,160 IN THE AREA CERTAINLY. 584 00:34:18,160 --> 00:34:24,040 I MIGHT ADD THE REASON I SPENT 585 00:34:24,040 --> 00:34:29,800 TWO SLIDES ON THIS AND I BELIEVE 586 00:34:29,800 --> 00:34:32,400 THIS PHARMACOEPIDEMIOLOGY 587 00:34:32,400 --> 00:34:35,080 APPROACH CAN BE A GOLD MINE FOR 588 00:34:35,080 --> 00:34:39,280 GENERATING HYPOTHESES AND 589 00:34:39,280 --> 00:34:39,840 SECONDARY ANALYSIS. 590 00:34:39,840 --> 00:34:42,360 ANOTHER PAPER THAT CAUGHT MY 591 00:34:42,360 --> 00:34:52,880 ATTENTION IS FROM DR. MARTINO. 592 00:34:56,760 --> 00:34:57,520 SOME RECOGNIZE THIS FROM THE 593 00:34:57,520 --> 00:34:59,080 LABORATORY AT SAN DIEGO AND 594 00:34:59,080 --> 00:35:05,000 WANTED TO ASK THE ROLE OF 595 00:35:05,000 --> 00:35:11,520 ACETATE IN GUT MICROBIOTA 596 00:35:11,520 --> 00:35:13,440 ASSOCIATED WITH GUT ALCOHOL 597 00:35:13,440 --> 00:35:15,640 CONSUMPTION AND THERE'S 598 00:35:15,640 --> 00:35:16,960 OVERGROWTH THAT OCCURS WITH 599 00:35:16,960 --> 00:35:27,400 UNHEALTHY USE OF ALCOHOL. 600 00:35:30,440 --> 00:35:32,640 ALSO ASSOCIATED WITH LIVER 601 00:35:32,640 --> 00:35:36,680 DISEASE AND TRYING TO IDENTIFY 602 00:35:36,680 --> 00:35:38,360 THE THIS IN LIVER DISEASE AND 603 00:35:38,360 --> 00:35:39,040 POSSIBLY IN ALCOHOL USE DISORDER 604 00:35:39,040 --> 00:35:41,240 AND THE MECHANISM IS NOT WELL 605 00:35:41,240 --> 00:35:44,960 KNOWN. 606 00:35:44,960 --> 00:35:50,960 AND SO SOME OF THE DATA THAT 607 00:35:50,960 --> 00:35:57,160 SUPPORT THIS IN ANIMALS FECAL 608 00:35:57,160 --> 00:36:00,680 SAMPLES WITH ALCOHOLISM WERE 609 00:36:00,680 --> 00:36:03,400 GIVEN TO MICE AND HEALTHY 610 00:36:03,400 --> 00:36:05,680 SUBJECTS ACTUALLY INCREASED THE 611 00:36:05,680 --> 00:36:08,760 SURVIVAL IN ALCOHOL ASSOCIATED 612 00:36:08,760 --> 00:36:09,240 HEPATITIS IN PEOPLE. 613 00:36:09,240 --> 00:36:11,320 THAT'S THE BACKGROUND IN THIS. 614 00:36:11,320 --> 00:36:21,880 WHAT THIS GROUP WANTED TO DO WAS 615 00:36:28,360 --> 00:36:34,800 FIGURE OUT THE ROLE OF ACETATE 616 00:36:34,800 --> 00:36:38,240 AND ALCOHOL HAS IT BROKEN DOWN 617 00:36:38,240 --> 00:36:49,160 TO ACETATE BIY ACETATE -- BY AL 618 00:36:51,880 --> 00:36:54,640 DEHYDROGENATE AND IT'S GOING IN 619 00:36:54,640 --> 00:36:55,720 THE INTESTINE WHERE IT PROVIDE 620 00:36:55,720 --> 00:36:58,120 AS A SOURCE OF ENERGY FOR 621 00:36:58,120 --> 00:36:58,520 BACTERIAL GROWTH. 622 00:36:58,520 --> 00:37:03,280 THEY PUT THE MICE ON A DIET THAT 623 00:37:03,280 --> 00:37:04,880 PRODUCES BASICALLY ALCOHOL 624 00:37:04,880 --> 00:37:07,960 DEPENDENCE AND THEY FOUND THAT 625 00:37:07,960 --> 00:37:09,760 ANAEROBIC GUT BACTERIA DID NOT 626 00:37:09,760 --> 00:37:11,360 BREAK DOWN THE ETHANOL TO 627 00:37:11,360 --> 00:37:14,440 ACETATE BUT RATHER USED THE 628 00:37:14,440 --> 00:37:18,640 ACETATE FROM GLUCONEO-GENESIS 629 00:37:18,640 --> 00:37:20,960 AND BASICALLY FOUND WHAT WAS 630 00:37:20,960 --> 00:37:24,920 HAPPENING WAS THERE WAS ACETATE 631 00:37:24,920 --> 00:37:26,640 DISSIMULATION FOLLOWING THE 632 00:37:26,640 --> 00:37:28,960 ETHANOL FEEDING AND THIS WAS NOT 633 00:37:28,960 --> 00:37:31,000 CAUSED BY METABOLISM. 634 00:37:31,000 --> 00:37:32,960 THE ACETATE IS BROKEN DOWN IN 635 00:37:32,960 --> 00:37:36,960 THE LIVER AND MOVES TO THE GUT 636 00:37:36,960 --> 00:37:42,960 AND STIMULATES THIS BACTERIAL 637 00:37:42,960 --> 00:37:53,440 SWITCH FROM BACTERIA THAT YOU 638 00:37:57,800 --> 00:38:00,360 GET AN INCREASE AND THERE'S A 639 00:38:00,360 --> 00:38:06,160 SHIFT IN THIS AND WHAT THEY ALSO 640 00:38:06,160 --> 00:38:09,600 DID WAS THEY CONFIRMED THIS WAS 641 00:38:09,600 --> 00:38:11,280 CAUSING THE SHIFT OF BACTERIAL 642 00:38:11,280 --> 00:38:12,000 GROWTH IN THE GUT. 643 00:38:12,000 --> 00:38:18,960 THEY TOOK HEALTHY ANIMALS AND 644 00:38:18,960 --> 00:38:21,560 INTERGASTRICLY INCREASED ACETATE 645 00:38:21,560 --> 00:38:24,440 LEVELS AND REPLICATED THE 646 00:38:24,440 --> 00:38:27,040 ALTERATIONS IN THE GUT 647 00:38:27,040 --> 00:38:30,960 MICROBIOTA FOUND WITH THE DIET. 648 00:38:30,960 --> 00:38:41,440 BASICALLY THE CONCLUSION IS 649 00:38:49,840 --> 00:38:51,240 THERE'S FURTHER WORK IN 650 00:38:51,240 --> 00:38:52,800 UNDERSTANDING HOW THE SHIFT IN 651 00:38:52,800 --> 00:38:55,640 THE GUT MICROBIOTA SHIFTS LIVER 652 00:38:55,640 --> 00:38:56,040 FUNCTION. 653 00:38:56,040 --> 00:39:00,440 IT'S CLEAR THE SOURCE OF ACETATE 654 00:39:00,440 --> 00:39:06,800 IS ACTUALLY BY THE DYSSIMULATION 655 00:39:06,800 --> 00:39:14,880 AND NOT METABOLIZING ALCOHOL. 656 00:39:14,880 --> 00:39:20,200 IT'S A COOL STUDY TO FIGURE OUT 657 00:39:20,200 --> 00:39:25,480 THE ROLE OF MECHANISM IN THE GUT 658 00:39:25,480 --> 00:39:27,120 MICROBIOTA IN LIVER DISEASE AND 659 00:39:27,120 --> 00:39:32,840 POSSIBLY IN ALCOHOL USE DISORDER 660 00:39:32,840 --> 00:39:33,080 ITSELF. 661 00:39:33,080 --> 00:39:38,360 MANY KNOW WE HAVE A BIG ACTIVITY 662 00:39:38,360 --> 00:39:41,320 IN METABOLISM AND HEALTH TO 663 00:39:41,320 --> 00:39:42,960 INTERACT WITH THE LIVER SOCIETY 664 00:39:42,960 --> 00:39:49,200 IN FINDING WAYS TO TREAT 665 00:39:49,200 --> 00:39:52,960 ALCOHOL-ASSOCIATED LIVER DISEASE 666 00:39:52,960 --> 00:39:55,840 AND ALCOHOL USE DISORDER. 667 00:39:55,840 --> 00:39:57,000 WE HOPE THE INTERACTION WILL 668 00:39:57,000 --> 00:40:01,040 CONTINUE AT THE CLINICAL AND 669 00:40:01,040 --> 00:40:07,040 BASIC RESEARCH LEVEL. 670 00:40:07,040 --> 00:40:15,120 >>THIS IS A STUDY FROM THE MAYO 671 00:40:15,120 --> 00:40:15,320 CLINIC. 672 00:40:15,320 --> 00:40:17,520 MANY KNOW RICHARD FOR HIS 673 00:40:17,520 --> 00:40:17,960 PIONEERING WORK. 674 00:40:17,960 --> 00:40:18,960 THERE'S A BACK STORY TO THIS ONE 675 00:40:18,960 --> 00:40:27,360 AS WELL. 676 00:40:27,360 --> 00:40:31,560 AND THIS IS A GENOME WIDE 677 00:40:31,560 --> 00:40:36,960 ASSOCIATION FOR SHOWING CHANGES 678 00:40:36,960 --> 00:40:41,560 IN CIRCULATING FIBROBLAST FACTOR 679 00:40:41,560 --> 00:40:42,360 21 IN PATIENTS WITH ALCOHOL USE 680 00:40:42,360 --> 00:40:48,880 DISORDER. 681 00:40:48,880 --> 00:40:54,960 AND CIRCULATING PLASMA LEVELS OF 682 00:40:54,960 --> 00:40:56,120 FGF21 ASSOCIATED WITH ALCOHOL 683 00:40:56,120 --> 00:40:56,840 AND CHRONIC CONSUMPTION IN THE 684 00:40:56,840 --> 00:40:58,920 PAST AND THAT'S THIS BACKGROUND, 685 00:40:58,920 --> 00:41:00,960 INJECTION OF FD21 REDUCED 686 00:41:00,960 --> 00:41:05,000 ALCOHOL INTAKE IN MICE. 687 00:41:05,000 --> 00:41:07,840 THERE'S ACTUALLY A STORY EARLIER 688 00:41:07,840 --> 00:41:10,160 TO THIS I REMEMBER WHEN THE 689 00:41:10,160 --> 00:41:13,520 PAPER CAME OUT IT WAS A GROUP IN 690 00:41:13,520 --> 00:41:16,840 THE U.K. AND HE BASICALLY SHOWED 691 00:41:16,840 --> 00:41:23,360 THERE WAS IN A GWAS STUDY THE 692 00:41:23,360 --> 00:41:24,640 RECEPTOR SHOWED THERE WAS A SNIP 693 00:41:24,640 --> 00:41:30,560 ASSOCIATED WITH THE RECEPTOR 694 00:41:30,560 --> 00:41:41,040 THAT WAS CORRELATED WITH AND 695 00:41:49,040 --> 00:41:51,040 THEY HYPOTHESIZED FGF21 WAS A 696 00:41:51,040 --> 00:41:57,320 FEEDBACK FROM EXCESSIVE 697 00:41:57,320 --> 00:41:57,840 DRINKING. 698 00:41:57,840 --> 00:42:00,200 THE STUDY WE'RE LOOKING AT NOW 699 00:42:00,200 --> 00:42:02,560 HAS ADDITIONAL GWAS NOT WORKING 700 00:42:02,560 --> 00:42:04,920 ON THE RECEPTOR FOR FGF21 BUT 701 00:42:04,920 --> 00:42:15,480 WORKING ON FGF21 ITSELF. 702 00:42:15,480 --> 00:42:16,760 AND EVALUATE THE FUNCTIONAL ROLE 703 00:42:16,760 --> 00:42:20,600 IN ALCOHOL USE DISORDER. 704 00:42:20,600 --> 00:42:25,320 ONE VARIANT LOCATED ON THE SNH16 705 00:42:25,320 --> 00:42:29,320 GENE WAS ASSOCIATED WITH PLASMA 706 00:42:29,320 --> 00:42:36,760 FGF21 LEVELS AND WITH AUD RISK. 707 00:42:36,760 --> 00:42:42,960 KNOCK DOWN OF THIS SNHG16-FG2 708 00:42:42,960 --> 00:42:51,840 CELLS INCREASED THE CATACOMBING 709 00:42:51,840 --> 00:42:55,280 MECHANISM AND BRAIN ORGANOIDS 710 00:42:55,280 --> 00:43:00,960 WAS BLOCKED BY CLASSIC FDA 711 00:43:00,960 --> 00:43:04,960 APPROVED MEDICATIONS FOR ALCOHOL 712 00:43:04,960 --> 00:43:05,320 USE DISORDER. 713 00:43:05,320 --> 00:43:08,160 THIS SUGGEST THE AXIS COULD BE A 714 00:43:08,160 --> 00:43:08,960 POTENTIAL PHARMACEUTICAL 715 00:43:08,960 --> 00:43:11,560 TREATMENT FOR THE TREATMENT OF 716 00:43:11,560 --> 00:43:12,800 ALCOHOL USE DISORDER. 717 00:43:12,800 --> 00:43:15,800 IN THE LEFT SIDE IN THE PATIENTS 718 00:43:15,800 --> 00:43:16,760 WITH WITH ALCOHOL USE DISORDER 719 00:43:16,760 --> 00:43:17,880 THE LEVELS WERE POSITIVELY 720 00:43:17,880 --> 00:43:20,000 CORRELATED WITH THE NUMBER OF 721 00:43:20,000 --> 00:43:21,800 HEAVY DRINKING DAYS AND THE 722 00:43:21,800 --> 00:43:31,000 BLOOD LEVELS OF GAMMA GUTEMOL 723 00:43:31,000 --> 00:43:33,080 TRANSFERASE. 724 00:43:33,080 --> 00:43:36,960 YOU SEE DRUG TREATMENT INCLUDING 725 00:43:36,960 --> 00:43:39,520 NATREXONE WAS ASSOCIATED WITH 726 00:43:39,520 --> 00:43:44,960 THE CHANGES IN THE ORGANOIDS. 727 00:43:44,960 --> 00:43:48,200 AND FINALLY ON THE RIGHT-HAND 728 00:43:48,200 --> 00:43:50,880 SIDE YOU GET THE FEEDBACK SCHEMA 729 00:43:50,880 --> 00:43:52,920 OUTLINED NOT ONLY THIS STUDY BUT 730 00:43:52,920 --> 00:43:55,160 PREVIOUS STUDIES THAT WERE THE 731 00:43:55,160 --> 00:43:55,560 BACKGROUND. 732 00:43:55,560 --> 00:43:59,240 THE DATA SUGGESTS GENETIC 733 00:43:59,240 --> 00:44:05,000 VARIANT OF SNHG16 CAN REGULATE 734 00:44:05,000 --> 00:44:07,760 FGF21 CONCENTRATIONS DECREASE 735 00:44:07,760 --> 00:44:10,600 EXPRESSION IN ENZYME ACTIVITY, 736 00:44:10,600 --> 00:44:13,800 ALCOHOL WHEN YOU ARE DRINKING IT 737 00:44:13,800 --> 00:44:16,960 STIMULATES FG21 LEVELS BUT THE 738 00:44:16,960 --> 00:44:25,000 RESEARCHERS WHO WORKED IN THIS 739 00:44:25,000 --> 00:44:33,000 AREA SUGGEST THE LEVELS FEEDBACK 740 00:44:33,000 --> 00:44:38,280 IS SHUT OFF ALCOHOL USE. 741 00:44:38,280 --> 00:44:39,760 DYSREGULATION OF THE SHUT OFF 742 00:44:39,760 --> 00:44:42,040 CAN LEAD TO AND CONTRIBUTE TO 743 00:44:42,040 --> 00:44:43,000 ALCOHOL USE DISORDER AND THE 744 00:44:43,000 --> 00:44:45,080 HYPOTHESIS WOULD BE IF YOU CAN 745 00:44:45,080 --> 00:44:46,920 STOP THIS SEQUENCE OF EVENTS YOU 746 00:44:46,920 --> 00:44:48,400 MIGHT BE ABLE TO PROVIDE ANOTHER 747 00:44:48,400 --> 00:44:49,960 TREATMENT FOR ALCOHOL USE 748 00:44:49,960 --> 00:44:52,760 DISORDER. 749 00:44:52,760 --> 00:44:54,440 IT'S REALLY INTRIGUING AND I 750 00:44:54,440 --> 00:44:56,480 THINK THERE'LL BE MORE WORK 751 00:44:56,480 --> 00:45:02,880 TRYING TO APPROVE EXACTLY HOW 752 00:45:02,880 --> 00:45:05,000 THIS FDF WHICH IS A LARGE 753 00:45:05,000 --> 00:45:05,560 MOLECULE IS AFFECTING THESE 754 00:45:05,560 --> 00:45:15,720 CHANGES. 755 00:45:17,840 --> 00:45:20,960 >>THE LAST TWO ARE IN THE 756 00:45:20,960 --> 00:45:29,000 DOMAIN OF TREATMENT AND AFFECTS 757 00:45:29,000 --> 00:45:29,560 OF TREATMENT CAUSED BY THE 758 00:45:29,560 --> 00:45:39,720 PANDEMIC. 759 00:45:43,080 --> 00:45:47,440 AND THIS PARTICULAR STUDY AND A 760 00:45:47,440 --> 00:45:50,120 GROUP LED BY STACY STERLING AT 761 00:45:50,120 --> 00:45:53,520 THE CENTER FOR ADDICTION AND 762 00:45:53,520 --> 00:45:56,040 MENTAL HEALTH IN KAISER 763 00:45:56,040 --> 00:45:56,920 PERMANENTE IN OAKLAND, 764 00:45:56,920 --> 00:45:58,760 CALIFORNIA, THEY INVESTIGATED 765 00:45:58,760 --> 00:46:00,560 THE IMPACT OF COVID-19 PANDEMIC 766 00:46:00,560 --> 00:46:01,680 ON ALCOHOL TREATMENT UTILIZATION 767 00:46:01,680 --> 00:46:04,800 AND POTENTIAL DISPARITIES. 768 00:46:04,800 --> 00:46:06,560 THE INVESTIGATORS ANALYZED 769 00:46:06,560 --> 00:46:08,720 ELECTRONIC HEALTH RECORDS AND 770 00:46:08,720 --> 00:46:11,840 CLAIMS FROM KAISER PERMANENTE 771 00:46:11,840 --> 00:46:15,040 NORTHERN CALIFORNIA FOR ADULTS 772 00:46:15,040 --> 00:46:16,960 WITH ALCOHOL ABUSE PROBLEMS 773 00:46:16,960 --> 00:46:18,400 PRE-COVID-19 AND DEFINED ALCOHOL 774 00:46:18,400 --> 00:46:20,960 USE PROBLEMS AS EXCEEDING THE 775 00:46:20,960 --> 00:46:23,840 DIETARY GUIDELINES OR IN ONE DAY 776 00:46:23,840 --> 00:46:24,960 EXCEEDING REACHING BINGE LEVELS 777 00:46:24,960 --> 00:46:28,960 OF DRINKING AND THEN THEY USE 778 00:46:28,960 --> 00:46:37,000 THE ALLOTMENT FOR ALCOHOL USE 779 00:46:37,000 --> 00:46:47,520 DISORDER AND THERE'S FOUR-FOLDS 780 00:46:54,960 --> 00:46:56,160 OF GREATER ODDS OF TREATMENT OF 781 00:46:56,160 --> 00:46:57,960 ONSET AND WHAT WAS ENCOURAGING 782 00:46:57,960 --> 00:47:00,120 IN MY VIEW AND THEIR VIEW WAS 783 00:47:00,120 --> 00:47:02,000 THIS WAS GREATER AMONG YOUNG 784 00:47:02,000 --> 00:47:02,240 ADULTS. 785 00:47:02,240 --> 00:47:03,720 IF LOOK AT THE TABLE YOU CAN SEE 786 00:47:03,720 --> 00:47:14,240 THERE'S A JUMP FROM 5.9% TO 20%. 787 00:47:38,360 --> 00:47:42,920 THAT WAS DURING PANDEMIC ONSET 788 00:47:42,920 --> 00:47:44,000 AND THERE WERE NO DIFFERENCES 789 00:47:44,000 --> 00:47:46,280 BETWEEN AGE, GROUP, RACE AND 790 00:47:46,280 --> 00:47:47,800 ETHNICITY IN THE TREATMENT 791 00:47:47,800 --> 00:47:48,440 ENGAGEMENT. 792 00:47:48,440 --> 00:47:53,000 SO EVERYONE SEEMED TO BE TAKING 793 00:47:53,000 --> 00:48:03,320 ADVANTAGE OF THIS. 794 00:49:05,240 --> 00:49:06,960 AND THEY LOOKED AT COLLEGE 795 00:49:06,960 --> 00:49:09,760 STUDENTS VIRTUAL AND IN-PERSON 796 00:49:09,760 --> 00:49:12,720 DRINKING CONTEXT DURING THE 797 00:49:12,720 --> 00:49:14,600 COVID-19 PANDEMIC. 798 00:49:14,600 --> 00:49:15,720 ALTHOUGH COLLEGE DRINKING 799 00:49:15,720 --> 00:49:18,960 DECREASED AT THE ONSET THIS 800 00:49:18,960 --> 00:49:20,280 IDENTIFIED MORE NUANCES 801 00:49:20,280 --> 00:49:22,200 INFORMATION AND THE RISK 802 00:49:22,200 --> 00:49:24,800 INFERRED BY EACH CONTEXT. 803 00:49:24,800 --> 00:49:25,320 SECONDARY ANALYSES WERE 804 00:49:25,320 --> 00:49:27,400 PERFORMED ON SCREENING DATA FROM 805 00:49:27,400 --> 00:49:29,960 A LARGE CLINICAL TRIAL ASSESSING 806 00:49:29,960 --> 00:49:31,400 COLLEGE STUDENT DRINKING 807 00:49:31,400 --> 00:49:34,040 INTERVENTIONS, PARTICIPATION, 808 00:49:34,040 --> 00:49:35,160 PARTICIPANTS ACROSS SIX COHORTS 809 00:49:35,160 --> 00:49:36,960 REPORTED ON THE FREQUENCY OF 810 00:49:36,960 --> 00:49:37,360 DRINKING. 811 00:49:37,360 --> 00:49:38,880 WHAT YOU CAN SEE HERE IN THE 812 00:49:38,880 --> 00:49:41,600 GRAPH AND WE PUT ARROWS TO MAKE 813 00:49:41,600 --> 00:49:43,680 THE LINES A LITTLE CLEARER. 814 00:49:43,680 --> 00:49:45,120 THE PROPORTION AND FREQUENCY OF 815 00:49:45,120 --> 00:49:48,960 DRINKING OUTSIDE THE HOME 816 00:49:48,960 --> 00:49:53,760 INCREASED AND WAS MOST 817 00:49:53,760 --> 00:50:04,000 CONSISTEN 818 00:50:07,360 --> 00:50:11,320 CONSISTENTLY DRINKING AT HOME IS 819 00:50:11,320 --> 00:50:13,880 NOT WITHOUT RISK AND IN FACT 820 00:50:13,880 --> 00:50:16,880 DRINKING AT HOME ALONE WAS 821 00:50:16,880 --> 00:50:22,680 ASSOCIATED WITH INCREASED ABUSE 822 00:50:22,680 --> 00:50:25,560 AND DEPENDENCE AND PERSONAL 823 00:50:25,560 --> 00:50:26,880 SOCIAL HANGOVER AND SOCIAL MEDIA 824 00:50:26,880 --> 00:50:28,960 CONSEQUENCES. 825 00:50:28,960 --> 00:50:32,600 EVEN DRINKING AT HOME WITH 826 00:50:32,600 --> 00:50:42,800 OTHERS VIRTUAL LY AND SOCIAL 827 00:50:42,800 --> 00:50:43,280 CONSEQUENCES. 828 00:50:43,280 --> 00:50:51,320 I THINK IT'S FASCINATING BECAUSE 829 00:50:51,320 --> 00:50:52,400 SOCIAL INTERACTION IS WHERE 830 00:50:52,400 --> 00:50:53,400 PEOPLE DRINK A LOT. 831 00:50:53,400 --> 00:50:55,000 THAT WAS ABROGATED INITIALLY IN 832 00:50:55,000 --> 00:50:57,480 THE FIRST FEW MONTHS OF THE 833 00:50:57,480 --> 00:51:02,520 PANDEMIC BUT CAME BACK. 834 00:51:02,520 --> 00:51:08,640 THE PANDEMIC MOVED FORWARD AND 835 00:51:08,640 --> 00:51:12,680 WE DO ALSO KNOW DRINKING ALONE 836 00:51:12,680 --> 00:51:13,680 HAS BEEN HISTORICALLY ASSOCIATED 837 00:51:13,680 --> 00:51:17,800 WITH INCREASED PATHOLOGY. 838 00:51:17,800 --> 00:51:19,280 THAT'S SOMETHING MORE OR LESS 839 00:51:19,280 --> 00:51:21,280 CONFIRMED BY THESE OBSERVATIONS 840 00:51:21,280 --> 00:51:21,520 AS WELL. 841 00:51:21,520 --> 00:51:26,560 SO FUTURE PREVENTION AND 842 00:51:26,560 --> 00:51:28,960 INTERVENTION EFFORTS AND IT MAY 843 00:51:28,960 --> 00:51:30,360 BENEFIT FROM CONSIDERING 844 00:51:30,360 --> 00:51:31,160 APPROACHES SPECIFIC TO DIFFERENT 845 00:51:31,160 --> 00:51:34,000 DRINKING CONTEXT. 846 00:51:34,000 --> 00:51:36,680 I WOULD ARGUE SHOULD INCLUDE 847 00:51:36,680 --> 00:51:38,520 APPROACHES SPECIFIC TO DIFFERENT 848 00:51:38,520 --> 00:51:39,560 DRINKING CONTEXT AND MAYBE 849 00:51:39,560 --> 00:51:40,880 DIFFERENT TREATMENTS AND 850 00:51:40,880 --> 00:51:43,560 DIFFERENT INTERVENTIONS WILL BE 851 00:51:43,560 --> 00:51:54,000 REQUIRED IN THESE DOMAINS. 852 00:51:56,720 --> 00:51:57,640 THE DIVISION DIRECTORS RECOMMEND 853 00:51:57,640 --> 00:52:00,960 SOME OF THE PAPERS I HIGHLIGHT 854 00:52:00,960 --> 00:52:11,200 EVERY TIME. 855 00:52:17,040 --> 00:52:24,160 AND SO THANKS EVERYBODY. 856 00:52:24,160 --> 00:52:29,000 I'M HAPPY TO TAKE QUESTIONS IF 857 00:52:29,000 --> 00:52:32,600 ANYBODY HAS QUESTIONS. 858 00:52:32,600 --> 00:52:34,720 MARY, DID I GIVE YOU JUSTICE TO 859 00:52:34,720 --> 00:52:36,960 YOUR STUDY? 860 00:52:36,960 --> 00:52:47,280 >>YES, THANK YOU. 861 00:52:59,480 --> 00:53:02,000 >>AND I FIND THE LOCKDOWN 862 00:53:02,000 --> 00:53:12,320 FINDING EXCITING. 863 00:53:46,040 --> 00:53:48,360 >>AND I THINK THERE'S A LOT OF 864 00:53:48,360 --> 00:53:49,960 BASIC RESEARCH BECAUSE IT MAY BE 865 00:53:49,960 --> 00:53:54,360 THAT THE TWO RECEPTORS ACTUALLY 866 00:53:54,360 --> 00:53:55,840 INTERACT WITH EACH OTHER AND IN 867 00:53:55,840 --> 00:53:59,200 WAYS WE DID NOT REALIZE BEFORE. 868 00:53:59,200 --> 00:54:03,960 AND SO THAT'S INTRIGUING. 869 00:54:03,960 --> 00:54:07,000 I BELIEVE LORENZO ARE YOU OUT 870 00:54:07,000 --> 00:54:10,920 THERE OR DAVID GOLDMAN? 871 00:54:10,920 --> 00:54:11,600 EITHER OF YOU? 872 00:54:11,600 --> 00:54:12,960 I BELIEVE THEY'RE PLANNING A 873 00:54:12,960 --> 00:54:14,440 CLINICAL TRIAL AND HAS A 874 00:54:14,440 --> 00:54:15,640 PROTOCOL IN FOR THAT, IS THAT 875 00:54:15,640 --> 00:54:16,680 CORRECT, DAVID? 876 00:54:16,680 --> 00:54:18,840 >>YES, IT IS. 877 00:54:18,840 --> 00:54:20,960 THE CLINICAL TRIAL HAS GONE 878 00:54:20,960 --> 00:54:25,400 THROUGH THE SCIENTIFIC REVIEW 879 00:54:25,400 --> 00:54:27,600 COMMITTEE, THE JOINT NIAAA-NIDA 880 00:54:27,600 --> 00:54:31,080 EFFORTS AND SHOULD BE BEFORE THE 881 00:54:31,080 --> 00:54:33,000 IRB RIGHT NOW AND HOPEFULLY 882 00:54:33,000 --> 00:54:33,200 SOON. 883 00:54:33,200 --> 00:54:41,520 THANK YOU, GEORGE. 884 00:54:41,520 --> 00:54:44,040 >>LORENZO AS YOU ALL KNOW HAS A 885 00:54:44,040 --> 00:54:47,120 JOINT APPOINTMENT WITH NIDA AND 886 00:54:47,120 --> 00:54:49,560 NIAAA AND VERY ACTIVE WITH HUMAN 887 00:54:49,560 --> 00:54:50,240 LABORATORY STUDIES. 888 00:54:50,240 --> 00:54:52,960 WE ALSO HAVE THE CAPABILITY OF 889 00:54:52,960 --> 00:54:54,960 RUNNING CLINICAL TRIALS. 890 00:54:54,960 --> 00:54:57,000 WE ALSO HAVE IN OUR DIVISION OF 891 00:54:57,000 --> 00:54:58,240 TREATMENT AND RECOVERY RESEARCH 892 00:54:58,240 --> 00:55:00,600 I THINK MOST OF YOU KNOW WE HAVE 893 00:55:00,600 --> 00:55:01,600 CONTRACT MECHANISM FOR THREE 894 00:55:01,600 --> 00:55:02,920 THINGS AND IF YOU DON'T KNOW 895 00:55:02,920 --> 00:55:05,440 ABOUT THIS, YOU SHOULD KNOW 896 00:55:05,440 --> 00:55:05,920 ABOUT IT. 897 00:55:05,920 --> 00:55:10,640 IT'S KIND OF FIRST COME, FIRST 898 00:55:10,640 --> 00:55:12,040 SERVE AND PRIORITY IS SET UP IF 899 00:55:12,040 --> 00:55:14,000 WE HAD MULTIPLE PEOPLE COMING 900 00:55:14,000 --> 00:55:14,880 FOR REQUESTS. 901 00:55:14,880 --> 00:55:16,320 YOU CAN DO AN ALCOHOL 902 00:55:16,320 --> 00:55:18,400 INTERACTION STUDY IN HUMANS. 903 00:55:18,400 --> 00:55:19,760 I'M TALKING ABOUT HUMAN STUDIES 904 00:55:19,760 --> 00:55:20,200 HERE. 905 00:55:20,200 --> 00:55:26,560 THESE ARE UNDER CONTRACT AND RUN 906 00:55:26,560 --> 00:55:27,760 OUT OF A DIVISION. 907 00:55:27,760 --> 00:55:33,440 YOU CAN REQUEST TO DO A HUMAN 908 00:55:33,440 --> 00:55:34,880 DRUG AND ALCOHOL INTERACTION 909 00:55:34,880 --> 00:55:37,000 STUDY WHICH IS CRITICAL FOR FDA 910 00:55:37,000 --> 00:55:41,000 APPROVAL. 911 00:55:41,000 --> 00:55:44,400 AND GETTING AN IND. 912 00:55:44,400 --> 00:55:46,480 AND I'M SORRY, NOT GETTING AN 913 00:55:46,480 --> 00:55:47,600 IND BECAUSE YOU HAVE TO HAVE 914 00:55:47,600 --> 00:55:50,080 THAT TO DO THAT. 915 00:55:50,080 --> 00:55:54,120 BUT FOR GOING ON TO PHASE II 916 00:55:54,120 --> 00:55:55,480 CLINICAL TRIAL AND WE DO HUMAN 917 00:55:55,480 --> 00:55:56,680 LABORATORY STUDIES. 918 00:55:56,680 --> 00:56:01,040 I THINK WE CAN AVERAGE ONE OR 919 00:56:01,040 --> 00:56:11,240 TWO A YEAR. 920 00:56:18,800 --> 00:56:24,720 WE'VE HAD TWO SUCCESSFUL 921 00:56:24,720 --> 00:56:25,640 CLINICAL TR 922 00:56:25,640 --> 00:56:28,320 CLINICAL TRIALS BIG PHARMA 923 00:56:28,320 --> 00:56:30,400 DENIED TO PICK THEM UP. 924 00:56:30,400 --> 00:56:34,160 ONE WAS A VASE YO PRESSANT 925 00:56:34,160 --> 00:56:36,120 ANTAGONIST THAT SHOWED A 926 00:56:36,120 --> 00:56:39,600 POSITIVE RESULT AND ONE WAS 927 00:56:39,600 --> 00:56:44,320 CHANTIX FOR THE TREATMENT ON 928 00:56:44,320 --> 00:56:48,960 THE MARKET AS A SMOKING 929 00:56:48,960 --> 00:56:50,480 CESSATION MARKET AND IT SEEMS TO 930 00:56:50,480 --> 00:56:52,960 SHOW IT HELPS WITH ALCOHOL AND A 931 00:56:52,960 --> 00:56:56,720 BETA ANTAGONIST AND MODULATING 932 00:56:56,720 --> 00:56:58,640 THE DOPAMINE SYSTEM AS A PARTIAL 933 00:56:58,640 --> 00:56:58,920 AGONIST. 934 00:56:58,920 --> 00:57:02,200 MORE THAN YOU WANTED TO KNOW, 935 00:57:02,200 --> 00:57:02,560 KATIE, I'M SURE. 936 00:57:02,560 --> 00:57:08,840 >>THANK YOU. 937 00:57:08,840 --> 00:57:10,840 ANY OTHER THOUGHTS OR QUESTIONS? 938 00:57:10,840 --> 00:57:13,920 >>IS THERE A LIST OF THE 939 00:57:13,920 --> 00:57:17,080 ARTICLES WE CAN READILY GET AND 940 00:57:17,080 --> 00:57:27,400 PASS ON TO OTHERS? 941 00:57:46,120 --> 00:57:49,240 WITH DIDN'T GET THE DIRECTOR'S 942 00:57:49,240 --> 00:57:59,400 REPORT. 943 00:58:10,560 --> 00:58:16,440 >>THERE ARE TWO REFERENCES AND 944 00:58:16,440 --> 00:58:21,080 THERE'S SOBERG AND SOBERG WAS 945 00:58:21,080 --> 00:58:31,200 2021. 946 00:58:32,680 --> 00:58:40,960 YOU CAN TYPE IN FGF AND SOBERG 947 00:58:40,960 --> 00:58:42,360 AND GUNTER SHULMAN. 948 00:58:42,360 --> 00:58:43,000 >>THANKS. 949 00:58:43,000 --> 00:58:53,280 THAT WAS GREAT. 950 00:59:06,320 --> 00:59:08,160 >>LAURA O'DELL HAS A QUESTION. 951 00:59:08,160 --> 00:59:11,800 >>DO YOU HAVE A QUESTION? 952 00:59:11,800 --> 00:59:17,600 I WAS INTERESTED AND FASCINATING 953 00:59:17,600 --> 00:59:28,160 BY THE RESULTS AND -- THE SPI 954 00:59:33,040 --> 00:59:43,440 SPIRONOLACTONE AND IT SEEMS 955 00:59:46,840 --> 00:59:49,120 THERE'S OTHER USE FOR THE DRUG. 956 00:59:49,120 --> 00:59:50,240 >>IT'S USED WIDELY. 957 00:59:50,240 --> 00:59:52,560 WHEN I PRESENTED THIS TO MY LAB 958 00:59:52,560 --> 00:59:57,480 A FEW WERE ON SPIRONOLACTONE. 959 00:59:57,480 --> 00:59:59,000 YOU MAY WANT TO SPEAK TO THIS 960 00:59:59,000 --> 01:00:05,280 BUT WHAT WE'RE TRYING TO DO BUT 961 01:00:05,280 --> 01:00:10,960 IT TOOK 15 YEARS FOR NALTREXONE 962 01:00:10,960 --> 01:00:12,240 TO BECOME AN FDA MEDICATION FROM 963 01:00:12,240 --> 01:00:15,440 THE DATE THE FIRST ANIMAL STUDY 964 01:00:15,440 --> 01:00:18,000 WAS DONE AND THE FIRST STUDY WAS 965 01:00:18,000 --> 01:00:19,320 DONE IN MONKEYS. 966 01:00:19,320 --> 01:00:21,360 I'M OLD ENOUGH TO REMEMBER ALL 967 01:00:21,360 --> 01:00:24,000 THIS STUFF SO YOU'RE STUCK WITH 968 01:00:24,000 --> 01:00:24,160 ME. 969 01:00:24,160 --> 01:00:25,640 AND THEN THE SECOND PIECE IS 970 01:00:25,640 --> 01:00:28,640 THAT IT TOOK 17 YEARS FOR 971 01:00:28,640 --> 01:00:30,600 ANOTHER TO GO FROM THE FIRST ROW 972 01:00:30,600 --> 01:00:33,080 DON'T STUDY STO BEING APPROVED 973 01:00:33,080 --> 01:00:38,440 AS A MEDICATION FOR ALCOHOL USE 974 01:00:38,440 --> 01:00:38,720 DISORDER. 975 01:00:38,720 --> 01:00:41,000 AND THAT WAS DONE BY STUDYING 976 01:00:41,000 --> 01:00:44,680 MOSTLY FOOD INTAKE IN FRANCE. 977 01:00:44,680 --> 01:00:47,640 MY POINT IS IN LIEU OF WAITING 978 01:00:47,640 --> 01:00:52,960 17 YEARS FOR A NOVEL MEDICATION 979 01:00:52,960 --> 01:00:57,760 TO GET INTO THE CLINIC WE'RE 980 01:00:57,760 --> 01:01:01,960 TRYING TO UTILIZE EXISTING 981 01:01:01,960 --> 01:01:07,000 MEDICATION S THAT MAY BE 982 01:01:07,000 --> 01:01:08,000 HELPFUL. 983 01:01:08,000 --> 01:01:11,040 >>I THINK YOU'RE RIGHTLY RIGHT. 984 01:01:11,040 --> 01:01:13,960 IT COULD BE AN ADVANTAGE AND 985 01:01:13,960 --> 01:01:15,760 DISADVANTAGE BECAUSE THE FDA 986 01:01:15,760 --> 01:01:17,480 APPROVAL FOR THE IND COMES 987 01:01:17,480 --> 01:01:18,840 EASILY. 988 01:01:18,840 --> 01:01:27,880 WE HAVE ALL THE SAFETY DATA. 989 01:01:27,880 --> 01:01:38,360 AND THEY HAD TO REVISE THE 990 01:01:38,640 --> 01:01:40,360 PROTOCOL FOR THE SAFETY STUDIO 991 01:01:40,360 --> 01:01:43,040 AND SOMETIMES AS WITH 992 01:01:43,040 --> 01:01:44,280 NALTREXONE, THE GROWTH COMPANY 993 01:01:44,280 --> 01:01:47,920 IS NOT NECESSARILY SO MOTIVATED 994 01:01:47,920 --> 01:01:51,240 REALLY TO PROMOTE THE DRUG. 995 01:01:51,240 --> 01:01:56,760 LET'S HOPE WITH THIS BEING A NEW 996 01:01:56,760 --> 01:02:02,160 INDICATION FOR SPIRONOLACTONE 997 01:02:02,160 --> 01:02:04,960 AND HOPE THE TRIAL IS POSITIVE. 998 01:02:04,960 --> 01:02:05,600 THANK YOU, GEORGE. 999 01:02:05,600 --> 01:02:07,320 >>THERE'S ALSO LICENSING ISSUES 1000 01:02:07,320 --> 01:02:09,880 AND WHETHER THE COMPANY WILL 1001 01:02:09,880 --> 01:02:17,960 MAKE MONEY IF IT'S GER ERIC AND 1002 01:02:17,960 --> 01:02:18,240 G 1003 01:02:18,240 --> 01:02:28,800 GABOPENTON IS NOW AN ADJUNCT FOR 1004 01:02:30,080 --> 01:02:40,560 ALCOHOL USE DISORDER AND WE NEED 1005 01:02:45,560 --> 01:02:55,040 TO SEE IF WE CAN TEST THE 1006 01:02:55,040 --> 01:03:00,960 HYPOTHESIS. 1007 01:03:00,960 --> 01:03:03,720 ANY OTHER THOUGHTS OR QUESTIONS? 1008 01:03:03,720 --> 01:03:03,960 ALL RIGHT. 1009 01:03:03,960 --> 01:03:06,920 I'LL LOOK IN THE CHAT TO SEE IF 1010 01:03:06,920 --> 01:03:07,920 ANYTHING CAME UP IN THE CHAT I 1011 01:03:07,920 --> 01:03:09,240 NEED TO ANSWER BUT I THINK 1012 01:03:09,240 --> 01:03:12,960 PEOPLE HAVE BEEN ANSWERING FOR 1013 01:03:12,960 --> 01:03:23,160 EVERYONE. 1014 01:03:31,880 --> 01:03:33,840 >>WE HAVE A BREAK SCHEDULED TO 1015 01:03:33,840 --> 01:03:36,960 THE NEXT STOP AT 2:45. 1016 01:03:36,960 --> 01:03:39,760 WE'LL BE TALKING ABOUT "ALL OF 1017 01:03:39,760 --> 01:03:40,440 US" RESEARCH. 1018 01:03:40,440 --> 01:03:42,680 IF WE CAN TAKE A BREAK AND COME 1019 01:03:42,680 --> 01:03:42,960 BACK -- 1020 01:03:42,960 --> 01:03:47,880 >>WHEN ARE WE DOING THE 1021 01:03:47,880 --> 01:03:49,800 FAREWELL TO OUR COUNCIL MEMBERS? 1022 01:03:49,800 --> 01:03:55,200 >>SO AT 2:45 WE HAVE THE TALK 1023 01:03:55,200 --> 01:03:58,480 AFTER THAT WE HAVE NANCY'S TALK 1024 01:03:58,480 --> 01:04:03,680 AND A CONCEPT CLEARANCE AND THEN 1025 01:04:03,680 --> 01:04:06,680 OPEN COUNCIL DISCUSSION AND 1026 01:04:06,680 --> 01:04:10,280 AFTER THAT THE LAST ITEM WILL BE 1027 01:04:10,280 --> 01:04:12,320 THE END BIDDING FAREWELL TO 1028 01:04:12,320 --> 01:04:13,040 RETIRING MEMBERS. 1029 01:04:13,040 --> 01:04:14,360 >>OKAY. 1030 01:04:14,360 --> 01:04:15,720 I JUST WANT TO MAKE SURE I'M ON 1031 01:04:15,720 --> 01:04:16,960 THE SAME PAGE. 1032 01:04:16,960 --> 01:04:18,040 ALL RIGHT. 1033 01:04:18,040 --> 01:04:20,280 SO I GUESS WE CAN ALL TAKE 1034 01:04:20,280 --> 01:04:20,960 ANOTHER BREAK WHICH IS FINE BY 1035 01:04:20,960 --> 01:04:23,440 ME. 1036 01:04:23,440 --> 01:04:28,160 MAYBE YOU CAN FIND OUT WHERE OUR 1037 01:04:28,160 --> 01:04:28,880 ERRANT COUNCIL MEMBERS WENT. 1038 01:04:28,880 --> 01:04:33,920 >>I THINK A COUPLE OF US JOINED 1039 01:04:33,920 --> 01:04:34,120 BACK. 1040 01:04:34,120 --> 01:04:35,560 DR. LANG AND DR. CHAMBERS IS 1041 01:04:35,560 --> 01:04:36,480 HERE. 1042 01:04:36,480 --> 01:04:37,280 >>ALL RIGHT. 1043 01:04:37,280 --> 01:04:38,360 WE HAVE TIME. 1044 01:04:38,360 --> 01:04:44,280 CHARLES, DO YOU ANTOF -- DO YOU 1045 01:04:44,280 --> 01:04:48,160 WANT TO INTRODUCE YOURSELF AND 1046 01:04:48,160 --> 01:04:48,520 THEN CHRISTINA? 1047 01:04:48,520 --> 01:04:54,320 >>HI, SORRY I MISSED THE 1048 01:04:54,320 --> 01:04:56,840 INTRODUCTION. 1049 01:04:56,840 --> 01:05:03,440 I'M CHUCK LANG AND INTERESTED IN 1050 01:05:03,440 --> 01:05:04,240 SKELETAL MUSCLE MYOPATHY. 1051 01:05:04,240 --> 01:05:14,520 >>AND CHRISTINA. 1052 01:05:20,680 --> 01:05:21,760 >>THE OTHER TWO HAVEN'T JOINED 1053 01:05:21,760 --> 01:05:24,960 YET. 1054 01:05:24,960 --> 01:05:31,560 >>OKAY. 1055 01:05:31,560 --> 01:05:33,000 WE HAVE TIME. 1056 01:05:33,000 --> 01:05:35,200 >>IF WE RECONVENE AT 2:40 WE 1057 01:05:35,200 --> 01:05:37,040 CAN START ON TIME. 1058 01:05:37,040 --> 01:06:15,480 >>LET'S ALL COME BACK AT 2:40 1059 01:06:15,480 --> 01:06:18,760 DR. GINSBURG SUPPORTS A WIDE 1060 01:06:18,760 --> 01:06:21,520 RANGE OF IMPACTFUL DISCOVERIES. 1061 01:06:21,520 --> 01:06:25,640 PRIOR TO JOINING ALL OF US HE 1062 01:06:25,640 --> 01:06:27,960 WAS FROM GENOMICS AND PRECISION 1063 01:06:27,960 --> 01:06:30,280 MEDICINE AT THE DUKE UNIVERSITY 1064 01:06:30,280 --> 01:06:32,920 SCHOOL OF MEDICINE WHERE HE 1065 01:06:32,920 --> 01:06:34,600 PIONEERED THE DEVELOPMENT OF 1066 01:06:34,600 --> 01:06:36,640 NOVEL DIAGNOSTICS IN GENOMICS 1067 01:06:36,640 --> 01:06:39,680 AND WAS PROFESSOR OF MEDICINE 1068 01:06:39,680 --> 01:06:40,680 AND BIOSTATISTICS AND 1069 01:06:40,680 --> 01:06:45,160 BIOINFORMATICS AND BIO 1070 01:06:45,160 --> 01:06:49,000 ENGINEERING AND PROFESSOR AT THE 1071 01:06:49,000 --> 01:06:52,840 SCHOOL OF NURSING WHERE HE 1072 01:06:52,840 --> 01:06:55,520 REMAINS AN ADJUNCT PROFESSOR AND 1073 01:06:55,520 --> 01:07:00,960 WAS A MEMBER OF THE HARVARD 1074 01:07:00,960 --> 01:07:03,000 MEDICAL SCHOOL FACTORY. 1075 01:07:03,000 --> 01:07:05,000 THROUGHOUT HIS CAREER HE'S 1076 01:07:05,000 --> 01:07:07,160 DEMONSTRATED A STRONG COMMITMENT 1077 01:07:07,160 --> 01:07:09,000 TO INNOVATION WITH WORK SPANNING 1078 01:07:09,000 --> 01:07:11,960 ONCOLOGY AND INFECTIOUS 1079 01:07:11,960 --> 01:07:12,600 DISEASES, CARDIOVASCULAR DISEASE 1080 01:07:12,600 --> 01:07:15,680 AND METABOLIC DISORDERS. 1081 01:07:15,680 --> 01:07:18,280 HE'S HELD LEADERSHIP ROLES IN 1082 01:07:18,280 --> 01:07:20,960 THE U.S. AND INTERNATIONALLY 1083 01:07:20,960 --> 01:07:21,960 SERVING AS CO-CHAIR OF THE 1084 01:07:21,960 --> 01:07:23,680 ROUNDTABLE ON GENOMIC AND 1085 01:07:23,680 --> 01:07:27,320 PRECISION HEALTH, A FOUNDING 1086 01:07:27,320 --> 01:07:30,640 CO-CHAIR OF THE 100K COHORTS 1087 01:07:30,640 --> 01:07:31,680 CONSORTIUM AND FOUNDER AND 1088 01:07:31,680 --> 01:07:34,960 PRESIDENT OF THE GLOBAL GENOMIC 1089 01:07:34,960 --> 01:07:39,600 MEDICINE COLLABORATIVE KNOWN AS 1090 01:07:39,600 --> 01:07:44,720 THE GTMC AIMED AT INTERNATIONAL 1091 01:07:44,720 --> 01:07:46,520 PARTNERSHIPS TO ADVANCE THE 1092 01:07:46,520 --> 01:07:48,800 IMPLEMENTATION OF PRECISION 1093 01:07:48,800 --> 01:07:49,040 MEDICINE. 1094 01:07:49,040 --> 01:07:52,280 AT NIH HE HAS SERVED ON THE 1095 01:07:52,280 --> 01:07:55,560 BOARD OF EXTERNAL EXPORTS AS AN 1096 01:07:55,560 --> 01:07:59,480 ADVISORY COUNCIL MEMBER TO THE 1097 01:07:59,480 --> 01:08:01,440 NATIONAL HUMAN GENOME RESEARCH 1098 01:08:01,440 --> 01:08:03,320 INSTITUTE AND THE NATIONAL 1099 01:08:03,320 --> 01:08:04,960 CENTERS FOR ADVANCING 1100 01:08:04,960 --> 01:08:06,360 TRANSLATIONAL SCIENCES AND 1101 01:08:06,360 --> 01:08:07,120 RECENTLY ON THE ADVISORY COUNCIL 1102 01:08:07,120 --> 01:08:09,000 TO THE DIRECTOR. 1103 01:08:09,000 --> 01:08:15,080 HE RECEIVED HIS M.D. AND Ph.D. 1104 01:08:15,080 --> 01:08:18,640 DEGREES IN BIO PHYSIC FROM 1105 01:08:18,640 --> 01:08:20,720 BOSTON UNIVERSITY AND COMPLETED 1106 01:08:20,720 --> 01:08:22,960 AN INTERNAL MEDICINE RESIDENCY 1107 01:08:22,960 --> 01:08:24,680 AT BETH ISRAEL HOSPITAL IN 1108 01:08:24,680 --> 01:08:27,680 BOSTON AND RECEIVED 1109 01:08:27,680 --> 01:08:28,280 POST-DOCTORAL TRAINING IN 1110 01:08:28,280 --> 01:08:30,440 CLINICAL CARDIOVASCULAR MEDICINE 1111 01:08:30,440 --> 01:08:32,520 AT BETH ISRAEL HOSPITAL AND 1112 01:08:32,520 --> 01:08:34,720 MOLECULAR BIOLOGY AT CHILDREN'S 1113 01:08:34,720 --> 01:08:38,120 HOSPITAL AS A FOUNDATION FELLOW 1114 01:08:38,120 --> 01:08:39,360 OF THE AMERICAN HEART 1115 01:08:39,360 --> 01:08:39,800 ASSOCIATION. 1116 01:08:39,800 --> 01:08:41,800 HE'S HAD A DISTINGUISHED CAREER. 1117 01:08:41,800 --> 01:08:46,760 HE'LL TELL US ABOUT POSSIBLE 1118 01:08:46,760 --> 01:08:47,960 PARTNERSHIP OPPORTUNITIES FOR 1119 01:08:47,960 --> 01:08:54,600 NIAAA WITH THE "ALL OF US" 1120 01:08:54,600 --> 01:09:03,600 RESEARCH PROGRAM I'VE BECOME A 1121 01:09:03,600 --> 01:09:04,280 FAN OF THE "ALL OF US" RESEARCH 1122 01:09:04,280 --> 01:09:14,760 PROGRAM AND IT'S ALL YOURS. 1123 01:09:16,000 --> 01:09:17,200 THANK YOU FOR THE KIND 1124 01:09:17,200 --> 01:09:19,680 INTRODUCTION. 1125 01:09:19,680 --> 01:09:23,680 I'LL TALK ABOUT THE RESEARCH 1126 01:09:23,680 --> 01:09:27,680 PROGRAM INDUCING IT TO YOU AND I 1127 01:09:27,680 --> 01:09:31,320 WANT TO TELL YOU ABOUT OUR 1128 01:09:31,320 --> 01:09:32,480 SCIENTIFIC DIRECTION AND 1129 01:09:32,480 --> 01:09:33,960 SPECIFICALLY WHERE THERE'S 1130 01:09:33,960 --> 01:09:36,560 EXISTING ACTIVITIES TAKING PLACE 1131 01:09:36,560 --> 01:09:40,320 IN OUR PROGRAM WITH THE EXTERNAL 1132 01:09:40,320 --> 01:09:43,280 RESEARCH COMMUNITY PRIMARILY 1133 01:09:43,280 --> 01:09:44,440 RELEVANT TO NIAAA AND THEN 1134 01:09:44,440 --> 01:09:47,480 FINISH UP WITH THE NOTION OF 1135 01:09:47,480 --> 01:09:48,160 PARTNERSHIP OPPORTUNITIES AND 1136 01:09:48,160 --> 01:09:51,680 SOME OF THE LANES OF WORK WE 1137 01:09:51,680 --> 01:09:52,320 MIGHT CONSIDER WORKING TOGETHER. 1138 01:09:52,320 --> 01:09:53,720 SO AGAIN, THANK YOU FOR ALLOWING 1139 01:09:53,720 --> 01:09:57,080 ME TO BE HERE TODAY. 1140 01:09:57,080 --> 01:09:59,640 LET ME START OFF WITH A SYNOPSIS 1141 01:09:59,640 --> 01:10:02,240 OF THE PROGRAM AND IT WAS 1142 01:10:02,240 --> 01:10:03,720 LAUNCHED REALLY IN 2015 AT THE 1143 01:10:03,720 --> 01:10:07,480 STATE OF THE UNION ADDRESS FOR 1144 01:10:07,480 --> 01:10:09,920 PRESIDENT OBAMA AND THE 1145 01:10:09,920 --> 01:10:11,680 PRECISION MEDICINE INITIATIVE 1146 01:10:11,680 --> 01:10:13,520 AND THE VISION AND MISSION 1147 01:10:13,520 --> 01:10:15,200 EMANATE FROM THE TIME WHEN THE 1148 01:10:15,200 --> 01:10:16,560 NOTION WAS CAN WE CREATE A 1149 01:10:16,560 --> 01:10:18,720 PLATFORM THAT WILL ACCELERATE 1150 01:10:18,720 --> 01:10:20,080 RESEARCH, ENABLE MEDICAL 1151 01:10:20,080 --> 01:10:23,680 BREAKTHROUGHS AND ENHANCE 1152 01:10:23,680 --> 01:10:25,200 PRECISION MEDICINE BY BRINGING 1153 01:10:25,200 --> 01:10:26,640 FORWARD THE TOOLS AND 1154 01:10:26,640 --> 01:10:27,600 DIAGNOSTICS FOR INDIVIDUALIZED 1155 01:10:27,600 --> 01:10:28,240 PREVENTION AND TREATMENT AND 1156 01:10:28,240 --> 01:10:31,680 CARE FOR ALL OF US AND ALL OF US 1157 01:10:31,680 --> 01:10:33,320 IS PURPOSEFUL IN THIS PARTICULAR 1158 01:10:33,320 --> 01:10:34,800 BUSINESS STATEMENT BECAUSE IT 1159 01:10:34,800 --> 01:10:37,280 REALLY IS MEANT TO REFLECT THE 1160 01:10:37,280 --> 01:10:39,720 FULL DIVERSITY OF PEOPLE IN THE 1161 01:10:39,720 --> 01:10:40,440 UNITED STATES. 1162 01:10:40,440 --> 01:10:43,240 AND WE'RE DOING THIS THROUGH A 1163 01:10:43,240 --> 01:10:45,920 VERY DIRECTIONAL PARTNERSHIP 1164 01:10:45,920 --> 01:10:48,160 ACTIVITY WITH OUR PARTICIPANTS 1165 01:10:48,160 --> 01:10:49,720 ACROSS THE UNITED STATES. 1166 01:10:49,720 --> 01:10:51,960 OUR GOAL IS TO DELIVER A 1167 01:10:51,960 --> 01:10:54,320 PLATFORM THAT ENABLES RESEARCH 1168 01:10:54,320 --> 01:10:56,800 THAT CONTAINS ONE OF THE RICHEST 1169 01:10:56,800 --> 01:10:57,960 BIO MEDICAL DATA SETS I'LL TELL 1170 01:10:57,960 --> 01:11:01,400 YOU ABOUT IN THE FUTURE AND THAT 1171 01:11:01,400 --> 01:11:03,680 SHOULD SERVE AS A MAGNET FOR 1172 01:11:03,680 --> 01:11:09,840 MULTIPLE STAKEHOLDERS AT NIH AND 1173 01:11:09,840 --> 01:11:11,440 THE INTRAMURAL RESEARCH 1174 01:11:11,440 --> 01:11:16,880 COMMUNITY AND EVENTUALLY 1175 01:11:16,880 --> 01:11:17,240 INTERNATIONALLY. 1176 01:11:17,240 --> 01:11:21,960 OUR GOAL IS TO ENROLL AT LEAST 1 1177 01:11:21,960 --> 01:11:24,840 MILLION PEOPLE AND RIGHT ABOUT 1178 01:11:24,840 --> 01:11:27,720 300,000 HAVE DATA AND WE'RE IN 1179 01:11:27,720 --> 01:11:30,880 TENSIONAL ABOUT DIFFERS -- 1180 01:11:30,880 --> 01:11:31,560 INTENTIONAL DIVERSITY. 1181 01:11:31,560 --> 01:11:36,320 OUR CURRENT PARTICIPANTS ARE 1182 01:11:36,320 --> 01:11:39,560 ALMOST 50% IDENTIFIED AS 1183 01:11:39,560 --> 01:11:41,400 NON-WHITE WITH RACE AND 1184 01:11:41,400 --> 01:11:43,000 ETHNICITY AND 80% ARE FROM 1185 01:11:43,000 --> 01:11:44,840 COMMUNITIES THAT HAVE NEVER 1186 01:11:44,840 --> 01:11:51,040 PARTICIPATED IN THE PAST IN ANY 1187 01:11:51,040 --> 01:11:51,680 BIOMEDICAL RESEARCH PROGRAMS. 1188 01:11:51,680 --> 01:11:53,800 YOU CAN SEE OUR RECRUITMENT 1189 01:11:53,800 --> 01:11:55,120 SITES IN THE SOUTHWEST HAVE HAD 1190 01:11:55,120 --> 01:11:56,440 THE GREATEST SUCCESS IN 1191 01:11:56,440 --> 01:11:58,560 ENROLLING PARTICIPANTS BUT WE'RE 1192 01:11:58,560 --> 01:12:03,240 ENROLLING PEOPLE FROM EVERY 1193 01:12:03,240 --> 01:12:13,800 STATE IN THE UNION DOES YOU SEE 1194 01:12:18,880 --> 01:12:20,080 A LARGE SPAINISH SPEAKING 1195 01:12:20,080 --> 01:12:21,280 POPULATION. 1196 01:12:21,280 --> 01:12:22,720 WE HAVEN'T DONE AS WELL IN THE 1197 01:12:22,720 --> 01:12:23,480 ASIAN POPULATIONS BUT WE'RE 1198 01:12:23,480 --> 01:12:26,400 TRYING TO AUGMENT OUR ACTIVITIES 1199 01:12:26,400 --> 01:12:27,440 IN THAT REGARD. 1200 01:12:27,440 --> 01:12:29,520 AND 80% UNDER REPRESENTED IN 1201 01:12:29,520 --> 01:12:32,280 BIOMEDICAL RESEARCH, THOSE ARE 1202 01:12:32,280 --> 01:12:33,720 FEATURES LIKE INDIVIDUALS WITH 1203 01:12:33,720 --> 01:12:34,640 COGNITIVE IMPAIRMENT OR 1204 01:12:34,640 --> 01:12:37,960 DISABILITIES OR FROM RURAL 1205 01:12:37,960 --> 01:12:39,360 COMMUNITIES OR EVEN PEDIATRIC 1206 01:12:39,360 --> 01:12:42,080 AGE GROUPS WHICH WE'RE ABOUT TO 1207 01:12:42,080 --> 01:12:45,800 INITIATE ENROLLMENT OF LATER 1208 01:12:45,800 --> 01:12:46,720 THIS YEAR. 1209 01:12:46,720 --> 01:12:49,520 GEORGE MENTIONED DATA AS PART OF 1210 01:12:49,520 --> 01:12:51,640 MY ROLE IN THE PROGRAM. 1211 01:12:51,640 --> 01:12:55,160 WE HAD FIVE MAIN DATA STREAMS 1212 01:12:55,160 --> 01:12:57,320 RIGHT NOW AND THE LARGEST DATA 1213 01:12:57,320 --> 01:13:00,400 SETS IS ON OUR SURVEYS. 1214 01:13:00,400 --> 01:13:01,320 WE'VE RELEASED ABOUT SIX 1215 01:13:01,320 --> 01:13:02,240 DIFFERENT SURVEYS. 1216 01:13:02,240 --> 01:13:05,680 I'LL SHOW YOU DETAIL ON ONES 1217 01:13:05,680 --> 01:13:06,960 PARTICULARLY RELEVANT TO NIAAA 1218 01:13:06,960 --> 01:13:09,760 IN A FEW MOMENTS. 1219 01:13:09,760 --> 01:13:12,880 PHYSICAL MEASURES, BY WHICH I 1220 01:13:12,880 --> 01:13:15,680 MEAN BLOOD PRESSURE, HEIGHT, 1221 01:13:15,680 --> 01:13:16,800 WAIST CIRCUMFERENCE AND THINGS 1222 01:13:16,800 --> 01:13:18,360 WE MAY CAPTURE FROM A 1223 01:13:18,360 --> 01:13:22,120 PARTICIPANT AT THE TIME OF 1224 01:13:22,120 --> 01:13:22,760 ENR 1225 01:13:22,760 --> 01:13:24,560 ENROLLMENT AT A FACE TO FACE 1226 01:13:24,560 --> 01:13:26,200 VISIT. 1227 01:13:26,200 --> 01:13:31,520 WE HAVE ROUGHLY 260,000 DATA 1228 01:13:31,520 --> 01:13:41,240 SETS IN OUR DATABASE AND IN 1229 01:13:41,240 --> 01:13:45,720 MARCH WE HAD 165,000 1230 01:13:45,720 --> 01:13:46,760 MEASUREMENTS WERE RELEASED IN 1231 01:13:46,760 --> 01:13:47,840 MARCH AND COMING SOON WILL BE 1232 01:13:47,840 --> 01:13:49,640 THE NEXT RELEASE PROBABLY IN 1233 01:13:49,640 --> 01:13:51,200 LATE MARCH OR APRIL OF THIS YEAR 1234 01:13:51,200 --> 01:13:53,840 WHERE WE'LL BRING THE TOTAL UP 1235 01:13:53,840 --> 01:13:57,040 TO ABOUT 250,000 WHOLE GENOME 1236 01:13:57,040 --> 01:14:00,680 SEQUENCES AND 320,000 MAKING IT 1237 01:14:00,680 --> 01:14:03,680 THE LARGEST GENOMIC PUBLICLY 1238 01:14:03,680 --> 01:14:04,320 ACCESSIBLE GENOMIC DATA SET ON 1239 01:14:04,320 --> 01:14:07,480 THE PLANET. 1240 01:14:07,480 --> 01:14:11,120 AND WEARABLE DEVICES ARE ANOTHER 1241 01:14:11,120 --> 01:14:13,240 PART OF OUR DATA STREAM. 1242 01:14:13,240 --> 01:14:15,680 YOU CAN SEE WE HAVE ROUGHLY 1243 01:14:15,680 --> 01:14:17,600 13,000 OF OUR PARTICIPANTS HAVE 1244 01:14:17,600 --> 01:14:19,560 PROVIDED PHYSICAL ACTIVITY AND 1245 01:14:19,560 --> 01:14:21,560 HEART RATE DATA THROUGH FITBITS 1246 01:14:21,560 --> 01:14:23,200 AND OTHER WATCH DATA WE'RE 1247 01:14:23,200 --> 01:14:23,680 COLLECTING. 1248 01:14:23,680 --> 01:14:25,040 BIO SAMPLES. 1249 01:14:25,040 --> 01:14:26,120 WE HAVE EVERY PARTICIPANT WE 1250 01:14:26,120 --> 01:14:29,880 ASKED TO DONATE A SAMPLE, WE 1251 01:14:29,880 --> 01:14:33,080 HAVE ROUGHLY 420,000 BIO SAMPLES 1252 01:14:33,080 --> 01:14:39,680 AND SAMPLES FROM 4420,000 1253 01:14:39,680 --> 01:14:44,560 PARTICIPANTS IN OUR BIO BANK AND 1254 01:14:44,560 --> 01:14:50,000 MAN 1255 01:14:50,000 --> 01:15:00,480 MANY ELOQUAT VARIANTS WERE 1256 01:15:05,480 --> 01:15:09,560 DETECT HAD HAD NEVER BEEN SEEN 1257 01:15:09,560 --> 01:15:11,640 IN PUBLICLY AVAILABLE GENOMIC 1258 01:15:11,640 --> 01:15:12,920 DATA SETS. 1259 01:15:12,920 --> 01:15:13,560 ILLUSTRATING THERE'S A LOT OF 1260 01:15:13,560 --> 01:15:15,480 INFORMATION WE NEED TO GET FROM 1261 01:15:15,480 --> 01:15:20,960 THE UNDER REPRESENTS COMMUNITIES 1262 01:15:20,960 --> 01:15:25,200 IN GENERAL AND THIS IS ONLY 1263 01:15:25,200 --> 01:15:27,000 GOING TO GROW IN POWER TO 1264 01:15:27,000 --> 01:15:28,440 UNDERSTAND GENETICS FROM THOSE 1265 01:15:28,440 --> 01:15:28,760 POPULATIONS. 1266 01:15:28,760 --> 01:15:31,680 ON THE RIGHT SIDE OF THE SLIDE 1267 01:15:31,680 --> 01:15:37,640 IS SYNOPSIS OF THE UNIQUE 1268 01:15:37,640 --> 01:15:48,160 INTERSECTIONS OF DATA AND THIS 1269 01:15:56,360 --> 01:16:02,360 IS A GENOTYPIC DATA SET. 1270 01:16:02,360 --> 01:16:05,600 THIS SPEAKS TO THE DIVERSITY TO 1271 01:16:05,600 --> 01:16:13,680 THE NUMBERS WE HAVE CURRENT LY 1272 01:16:13,680 --> 01:16:17,720 AND WE HAVE DATA RESEARCH 1273 01:16:17,720 --> 01:16:21,760 AGREEMENTS IN WHICH OVER OVER 1274 01:16:21,760 --> 01:16:25,000 440 INSTITUTIONS AND HAD AN 1275 01:16:25,000 --> 01:16:26,400 EMPHASIS ON NON-FOR-PROFIT 1276 01:16:26,400 --> 01:16:28,920 INSTITUTIONS AND ACADEMIC AND 1277 01:16:28,920 --> 01:16:30,160 HEALTH CARE ORGANIZATIONS WITH 1278 01:16:30,160 --> 01:16:32,080 THE SPECIFIC OUTREACH TO 1279 01:16:32,080 --> 01:16:34,000 HISTORICALLY BLACK COLLEGES AND 1280 01:16:34,000 --> 01:16:35,680 UNIVERSITIES AND 1281 01:16:35,680 --> 01:16:42,440 HISPANIC-SERVING INSTITUTIONS. 1282 01:16:42,440 --> 01:16:44,280 WE HAVE OVER 3,000 PROJECTS 1283 01:16:44,280 --> 01:16:47,000 UNDERWAY AND THIS IS UP TO 120 1284 01:16:47,000 --> 01:16:50,280 PUBLICATIONS AS OF THIS WEEK 1285 01:16:50,280 --> 01:16:52,600 COMING FROM THE "ALL OF US" DATA 1286 01:16:52,600 --> 01:16:53,560 SET. 1287 01:16:53,560 --> 01:16:56,720 I MENTIONED DIVERSITY. 1288 01:16:56,720 --> 01:16:58,760 WE ARE EMPHASIZING THE DIVERSITY 1289 01:16:58,760 --> 01:16:59,680 OF OUR RESEARCH WORKFORCE USING 1290 01:16:59,680 --> 01:17:03,520 OUR DATA AND PROUD TO SAY ABOUT 1291 01:17:03,520 --> 01:17:05,520 50% OF OUR RESEARCHERS ARE 1292 01:17:05,520 --> 01:17:08,400 SELF-IDENTIFIED AS NON-WHITE. 1293 01:17:08,400 --> 01:17:10,320 THE RESEARCHER WORK BENCH. 1294 01:17:10,320 --> 01:17:12,400 THIS IS A SCREEN SHOT ON THE 1295 01:17:12,400 --> 01:17:16,680 LEFT OF WHAT YOU'D SEE GOING TO 1296 01:17:16,680 --> 01:17:22,760 THE URL ALL OF US DOT-ORG AND 1297 01:17:22,760 --> 01:17:24,520 YOU'LL SEE TILES PUBLICLY 1298 01:17:24,520 --> 01:17:24,760 AVAILABLE. 1299 01:17:24,760 --> 01:17:27,040 MAYBE HARD TO SEE BUT THEY'RE 1300 01:17:27,040 --> 01:17:29,080 E.H.R. DATA AND PHYSICAL MEASURE 1301 01:17:29,080 --> 01:17:31,320 DATA AND A VARIETY OF SURVEY 1302 01:17:31,320 --> 01:17:33,600 DATA WITH A NUMBER OF ELEMENTS 1303 01:17:33,600 --> 01:17:34,360 IN THEM LISTED IN THE NUMBERS 1304 01:17:34,360 --> 01:17:35,680 YOU CAN SEE HERE. 1305 01:17:35,680 --> 01:17:38,640 THIS IS SOMETHING THAT YOU CAN 1306 01:17:38,640 --> 01:17:39,280 USE TODAY. 1307 01:17:39,280 --> 01:17:43,400 IT'S PUBLICLY AVAILABLE AND I'LL 1308 01:17:43,400 --> 01:17:44,880 SHOW YOU LITTLE MORE ABOUT 1309 01:17:44,880 --> 01:17:46,640 PUBLICLY AVAILABLE DATA IN A 1310 01:17:46,640 --> 01:17:46,880 SECOND. 1311 01:17:46,880 --> 01:17:49,560 ONE OF THE THINGS WE'RE PROUD OF 1312 01:17:49,560 --> 01:17:50,880 IN THE WORK BENCH IS THE 1313 01:17:50,880 --> 01:17:53,680 FACILITY WITH WHICH INDIVIDUALS 1314 01:17:53,680 --> 01:17:55,200 CAN CARRY OUT COMPLEX STUDIES. 1315 01:17:55,200 --> 01:17:57,400 I WANTED TO SHOW A QUICK EXAMPLE 1316 01:17:57,400 --> 01:18:01,840 OF A STUDY DONE SOME TIME THIS 1317 01:18:01,840 --> 01:18:05,840 PAST MONTH BY A POSTDOC AT 1318 01:18:05,840 --> 01:18:06,160 NHGRI. 1319 01:18:06,160 --> 01:18:08,560 HE WENT TO THE WORK BENCH AIMING 1320 01:18:08,560 --> 01:18:12,480 TO DO A STUDY FOR DIABETES 1321 01:18:12,480 --> 01:18:14,360 MYELITIS DONE IN MANY TIMES IN 1322 01:18:14,360 --> 01:18:15,440 MANY REGIONS OF THE GLOBE OVER 1323 01:18:15,440 --> 01:18:22,080 AND OVER BUT THE POINT IF THIS 1324 01:18:22,080 --> 01:18:24,920 WERE A GRANT PROPOSAL IT WOULD 1325 01:18:24,920 --> 01:18:27,000 HAVE BEEN ONE TO TWO YEARS TO 1326 01:18:27,000 --> 01:18:28,840 PRODUCE A GWAS RESULT AND HE 1327 01:18:28,840 --> 01:18:31,560 WENT TO OUR WORK SPACE AND 1328 01:18:31,560 --> 01:18:33,600 CREATED A COHORT FOR TYPE II 1329 01:18:33,600 --> 01:18:34,440 DIABETES THROUGH FEATURES I 1330 01:18:34,440 --> 01:18:37,960 WON'T GO INTO THE DETAILS BUT 1331 01:18:37,960 --> 01:18:38,600 ILLUSTRATED IN THE FLOW CHART 1332 01:18:38,600 --> 01:18:43,320 BELOW AND WAS ABLE TO REFINE THE 1333 01:18:43,320 --> 01:18:45,600 COHORT WITH OTHER CLINICAL 1334 01:18:45,600 --> 01:18:47,200 FEATURES AND IMPORT THE SCRIPTS 1335 01:18:47,200 --> 01:18:51,680 TO RUN A GWAS AND WAS ABLE TO 1336 01:18:51,680 --> 01:18:53,880 REPLICATE THE GENETIC VARIATION 1337 01:18:53,880 --> 01:18:57,360 THAT'S BEEN SHOWN MANY TIMES AS 1338 01:18:57,360 --> 01:18:58,800 ASSOCIATED WITH TYPE II DIABETES 1339 01:18:58,800 --> 01:19:01,880 USING A COHORT OF 20,000 1340 01:19:01,880 --> 01:19:03,680 PARTICIPANTS AND COMPUTE TIME OF 1341 01:19:03,680 --> 01:19:08,160 20 MINUTES AND A COST OF $37. 1342 01:19:08,160 --> 01:19:10,000 THAT'S PRETTY REMARKABLE I WOULD 1343 01:19:10,000 --> 01:19:10,160 SAY. 1344 01:19:10,160 --> 01:19:12,960 I SHOULD MENTION ALL OF OUR WORK 1345 01:19:12,960 --> 01:19:15,520 BENCH USERS START OFF WITH A 1346 01:19:15,520 --> 01:19:17,320 $300 CLOUD CREDIT. 1347 01:19:17,320 --> 01:19:20,120 AN OPPORTUNITY TO DO FIVE TO TEN 1348 01:19:20,120 --> 01:19:21,000 GWAS STUDIES. 1349 01:19:21,000 --> 01:19:24,840 I THINK THIS IS AN AMAZING -- 1350 01:19:24,840 --> 01:19:27,680 THIS PARTICULAR PERSON WAS A 1351 01:19:27,680 --> 01:19:29,680 GENETICISTS BUT HAD NEVER DONE A 1352 01:19:29,680 --> 01:19:34,040 GWAS BEFORE SO IT'S ALSO QUITE 1353 01:19:34,040 --> 01:19:34,320 IMPRESSIVE. 1354 01:19:34,320 --> 01:19:37,400 I WANT TO SHIFT GEARS OR MOVE TO 1355 01:19:37,400 --> 01:19:39,680 A SECTION WHERE I'LL BRIEFLY 1356 01:19:39,680 --> 01:19:42,320 DESCRIBE THE ALL OF US 1357 01:19:42,320 --> 01:19:43,680 SCIENTIFIC FRAMEWORK AND AREAS 1358 01:19:43,680 --> 01:19:44,960 OF RESEARCH ALREADY ONGOING 1359 01:19:44,960 --> 01:19:46,760 RELEVANT TO ALCOHOLISM AND 1360 01:19:46,760 --> 01:19:47,360 ALCOHOL ABUSE. 1361 01:19:47,360 --> 01:19:49,760 THE FIRST SLIDE IS GOING TO BE A 1362 01:19:49,760 --> 01:19:52,440 SNAPSHOT OF WHAT WE CALL THE 1363 01:19:52,440 --> 01:19:53,640 SCIENTIFIC ROAD MAP OF THE ALL 1364 01:19:53,640 --> 01:19:54,880 OF US RESEARCH PROGRAM. 1365 01:19:54,880 --> 01:19:56,600 ITS WAS MY CHARGE IN JOINING ALL 1366 01:19:56,600 --> 01:19:58,000 OF US A YEAR AGO TO DEVELOP 1367 01:19:58,000 --> 01:19:58,520 THIS. 1368 01:19:58,520 --> 01:20:01,840 I'M NOT GOING TO GO INTO THE A 1369 01:20:01,840 --> 01:20:02,920 LOT OF DETAIL BUT WANT TO GIVE A 1370 01:20:02,920 --> 01:20:06,280 FLAVOR OF THE WAY WE THINK OF 1371 01:20:06,280 --> 01:20:08,560 THE RESEARCH STRATEGY TO 1372 01:20:08,560 --> 01:20:11,640 EVENTUALLY LEAD TO FUNDING 1373 01:20:11,640 --> 01:20:16,640 OPPORTUNITIES IN THE NIH AND 1374 01:20:16,640 --> 01:20:17,440 INTRAMURAL AND EXTRAMURAL 1375 01:20:17,440 --> 01:20:19,480 OPPORTUNITIES AND LOOK AT WAYS 1376 01:20:19,480 --> 01:20:21,000 TO ASSESS RISK, DIAGNOSIS AND 1377 01:20:21,000 --> 01:20:24,640 EVENTUALLY TREATMENT PAIR DIMES. 1378 01:20:24,640 --> 01:20:25,840 -- PARADIGMS. 1379 01:20:25,840 --> 01:20:29,440 IT STARTS OFF AND THIS IS THE 1380 01:20:29,440 --> 01:20:30,160 FOUNDATIONAL START THE WORK 1381 01:20:30,160 --> 01:20:31,680 BENCH WHERE RESEARCHERS COME TO 1382 01:20:31,680 --> 01:20:32,920 DO THEIR SCIENCE AND THE DATA 1383 01:20:32,920 --> 01:20:33,600 SETS THAT EXIST THERE. 1384 01:20:33,600 --> 01:20:35,920 I MENTIONED ALREADY WE HAVE FIVE 1385 01:20:35,920 --> 01:20:39,280 MAIN DATA STREAMS, ELECTRONIC 1386 01:20:39,280 --> 01:20:41,760 HEALTH REPORTS AND PARTICIPANT 1387 01:20:41,760 --> 01:20:42,680 PROVIDED INFORMATION AND BIO 1388 01:20:42,680 --> 01:20:43,880 METRIC DATA AND GENOMES. 1389 01:20:43,880 --> 01:20:46,720 WE'RE IN THE PROCESS OF DOING A 1390 01:20:46,720 --> 01:20:51,000 LARGE SCALE EXPANSION OF OUR 1391 01:20:51,000 --> 01:20:52,200 PHENOTYPIC REPERTOIRE USING BIO 1392 01:20:52,200 --> 01:20:55,480 SAMPLES TO VARIOUS CLINICAL OR 1393 01:20:55,480 --> 01:20:56,200 IMMUNOLOGIC ASSAYS. 1394 01:20:56,200 --> 01:21:01,280 A VARIETY OF METABOLOMICS, 1395 01:21:01,280 --> 01:21:05,840 PROTEOMICS AND DIGITAL HEALTH. 1396 01:21:05,840 --> 01:21:08,040 ONE STRATEGY FOCUS AREA WE ARE 1397 01:21:08,040 --> 01:21:10,440 LAUNCHING IS AN EMPHASIS TO 1398 01:21:10,440 --> 01:21:12,280 CREATE THE NOVEL TOOLS OUR 1399 01:21:12,280 --> 01:21:13,560 RESEARCHERS WILL NEED TO HAVE 1400 01:21:13,560 --> 01:21:16,000 AVAILABLE TO THEM TO UTILIZE 1401 01:21:16,000 --> 01:21:20,120 THESE HIGH-DIMENSIONAL DATA SETS 1402 01:21:20,120 --> 01:21:22,200 THAT HAVE AN IMPORTANT TEMPORAL 1403 01:21:22,200 --> 01:21:24,680 ASPECT TO THEM. 1404 01:21:24,680 --> 01:21:27,560 ON TOP OF THIS FOUNDATION, WE'RE 1405 01:21:27,560 --> 01:21:29,000 CALLING THE DRIVERS AND 1406 01:21:29,000 --> 01:21:30,200 EXPOSURES THAT LEAD TO HEALTH 1407 01:21:30,200 --> 01:21:33,120 AND DISEASE TRANSITIONS. 1408 01:21:33,120 --> 01:21:34,240 A LOT OF THIS CAME FROM THE 1409 01:21:34,240 --> 01:21:35,400 REPORT TO THE ADVISORY COMMITTEE 1410 01:21:35,400 --> 01:21:38,400 OF THE DIRECTOR ON PRECISION 1411 01:21:38,400 --> 01:21:40,040 MEDICINE INITIATIVE WHEN FRANCIS 1412 01:21:40,040 --> 01:21:42,040 COLLINS HAD THAT ROLE. 1413 01:21:42,040 --> 01:21:45,680 SO LIFESTYLE, WHICH INCLUDES 1414 01:21:45,680 --> 01:21:46,320 SUBSTANCES RELEVANT TO THIS 1415 01:21:46,320 --> 01:21:49,200 INSTITUTE BUT ALSO THE IMPACT OF 1416 01:21:49,200 --> 01:21:49,680 ENVIRONMENT AND SOCIAL 1417 01:21:49,680 --> 01:21:51,000 DETERMINATES OF HEALTH. 1418 01:21:51,000 --> 01:21:55,640 THE IMPACT OF HEALTH INEQUITIES 1419 01:21:55,640 --> 01:21:57,040 AS WELL AS OR GAPS IN HEALTH 1420 01:21:57,040 --> 01:22:00,680 EQUITY AND GENETICS AND BIOLOGY 1421 01:22:00,680 --> 01:22:03,520 WE VIEW THEM AS FUNDAMENTAL 1422 01:22:03,520 --> 01:22:05,600 DRIVERS OF HEALTH AND HOW THEY 1423 01:22:05,600 --> 01:22:06,600 INTERACT LEAD TO OTHER FOCUS 1424 01:22:06,600 --> 01:22:10,040 AREAS OF THE PROGRAM WHICH ARE 1425 01:22:10,040 --> 01:22:11,320 PROMINENT AND RARE HEALTH 1426 01:22:11,320 --> 01:22:13,600 CONDITIONS AND MEANT TO ADDRESS 1427 01:22:13,600 --> 01:22:16,600 THE CDC'S TOP TEN CAUSES OF 1428 01:22:16,600 --> 01:22:19,680 MORBIDITY AND MORTALITY WITH AN 1429 01:22:19,680 --> 01:22:22,080 EMPHASIS ON UNDER REPRESENTED 1430 01:22:22,080 --> 01:22:24,520 GROUPS AS WELL. 1431 01:22:24,520 --> 01:22:26,760 HOW THESE EXPOSURES AND DRIVERS 1432 01:22:26,760 --> 01:22:29,520 INFLUENCE MATERNAL AND CHILD 1433 01:22:29,520 --> 01:22:30,800 HEALTH OR RESULT IN HEALTHY 1434 01:22:30,800 --> 01:22:32,400 AGING ACROSS THE LIFE SPAN AND 1435 01:22:32,400 --> 01:22:35,680 THE UPPER RIGHT HAND FOCUS AREA 1436 01:22:35,680 --> 01:22:37,040 REFLECTS OUR COMMITMENT TO 1437 01:22:37,040 --> 01:22:39,680 RESULTS BACK TO PARTICIPANTS AND 1438 01:22:39,680 --> 01:22:40,680 UNDERSTAND THE DOWN STREAM 1439 01:22:40,680 --> 01:22:43,680 IMPACT ON INDIVIDUAL AND 1440 01:22:43,680 --> 01:22:44,320 POPULATION HEALTH. 1441 01:22:44,320 --> 01:22:48,040 AND FINALLY TO FULLY REALIZE 1442 01:22:48,040 --> 01:22:50,520 THIS VISION TO WORK CLOSELY WITH 1443 01:22:50,520 --> 01:22:53,040 OTHER INSTITUTES AND CENTERS AT 1444 01:22:53,040 --> 01:22:54,840 THE NIH AND COMPANIES, PAIRS AND 1445 01:22:54,840 --> 01:22:57,240 POLICY MAKERS TO EFFECTIVELY 1446 01:22:57,240 --> 01:22:59,680 TRANSLATE THE WORK BENCH 1447 01:22:59,680 --> 01:23:03,120 FINDINGS TO TANGIBLE BENEFITS 1448 01:23:03,120 --> 01:23:04,840 FOR SOCIETY AND POPULATION 1449 01:23:04,840 --> 01:23:05,080 HEALTH. 1450 01:23:05,080 --> 01:23:06,760 I KNOW I WENT THROUGH A LOT AND 1451 01:23:06,760 --> 01:23:08,840 THERE'S A VERY EXTENSIVE PLAN 1452 01:23:08,840 --> 01:23:10,000 BEHIND HIT THIS BUT WANTED TO 1453 01:23:10,000 --> 01:23:13,400 GIVE A SENSE OF HOW THE PROGRAM 1454 01:23:13,400 --> 01:23:23,640 HAS SHAPED UP. 1455 01:23:29,200 --> 01:23:31,520 IF YOU GO TO THE URL SHOWED 1456 01:23:31,520 --> 01:23:36,720 EARLIER AND DO A SEARCH FROM THE 1457 01:23:36,720 --> 01:23:47,400 DATA ALREADY COLLECT ED E.H.R. 1458 01:23:54,520 --> 01:23:57,680 INFORMATION AND THERE'S EVERY 1459 01:23:57,680 --> 01:23:59,280 LAP IN THE DIAGNOSES OR TERMS 1460 01:23:59,280 --> 01:24:01,920 BUT WANT TO GIVE A FLAVOR OF 1461 01:24:01,920 --> 01:24:04,800 WHAT'S IN THE DATA SET. 1462 01:24:04,800 --> 01:24:09,240 THERE'S ONE OF OUR LIFESTYLE 1463 01:24:09,240 --> 01:24:11,640 SURVEYS WE AND PEOPLE ANSWERED 1464 01:24:11,640 --> 01:24:14,160 THE SURVEY AND YOU CAN SEE THE 1465 01:24:14,160 --> 01:24:19,600 FIRST QUESTIONS ARE AROUND 1466 01:24:19,600 --> 01:24:24,560 TOBACCO USE, ELECTRONIC MODES OF 1467 01:24:24,560 --> 01:24:27,680 TOBACCO USE AND IN YOUR LIFE 1468 01:24:27,680 --> 01:24:31,600 HAVE YOU HAD AT LEAST ONE DRINK 1469 01:24:31,600 --> 01:24:33,560 OF ALCOHOL NOT COUNTING SMALL 1470 01:24:33,560 --> 01:24:36,400 TAPES OR SIPS. 1471 01:24:36,400 --> 01:24:37,880 315 PEOPLE RESPONDED YET YES TO 1472 01:24:37,880 --> 01:24:38,680 THE QUESTION. 1473 01:24:38,680 --> 01:24:41,760 YOU CAN SEE THE VARIOUS DRINKING 1474 01:24:41,760 --> 01:24:42,720 FREQUENCIES ILLUSTRATED HERE 1475 01:24:42,720 --> 01:24:45,560 MONTHLY OR LESS, RANGING TO FOUR 1476 01:24:45,560 --> 01:24:49,200 OR MORE PER WEEK AND IF YOU 1477 01:24:49,200 --> 01:24:51,760 DRILL DOWN ON A TYPICAL WEEK, 1478 01:24:51,760 --> 01:24:53,960 YOU CAN SEE HOW IT BREAKS DOWN 1479 01:24:53,960 --> 01:24:58,080 TENS OF THOUSAND OF PEOPLE 1480 01:24:58,080 --> 01:25:00,720 HAVING MULTIPLE DRINKS AND SOME 1481 01:25:00,720 --> 01:25:03,080 PER DAY AND 1,000 HAVING SEVEN 1482 01:25:03,080 --> 01:25:05,200 TO NINE OR TEN OR MORE DRINKS 1483 01:25:05,200 --> 01:25:05,960 PER DAY. 1484 01:25:05,960 --> 01:25:07,400 SO THIS IS THE KIND OF DATA 1485 01:25:07,400 --> 01:25:12,560 WE'VE BEEN COLLECTING. 1486 01:25:12,560 --> 01:25:23,080 I CAN'T SAY I'M SURE THERE'S 1487 01:25:23,560 --> 01:25:27,680 OPPORTUNITIES TO ENHANCE WAYS 1488 01:25:27,680 --> 01:25:30,040 WE'RE COLLECTING DATA FROM 1489 01:25:30,040 --> 01:25:36,480 PARTL 1490 01:25:36,480 --> 01:25:36,760 PARTLIES. 1491 01:25:36,760 --> 01:25:37,720 ANYBODY CAN SEARCH WHAT PROJECTS 1492 01:25:37,720 --> 01:25:40,080 ARE HAPPENING AT THE RESEARCHER 1493 01:25:40,080 --> 01:25:43,480 WORK BENCH USING THIS URL. 1494 01:25:43,480 --> 01:25:46,080 AND WHEN WE USE THE TERM ALCOHOL 1495 01:25:46,080 --> 01:25:48,160 USE TO DO OUR SEARCH, WE COME UP 1496 01:25:48,160 --> 01:25:50,000 WITH 22 ACTIVE PROJECTS ALREADY 1497 01:25:50,000 --> 01:25:51,840 ON THE RESEARCH TO WORK BENCH. 1498 01:25:51,840 --> 01:25:54,280 I'M ILLUSTRATING SO YOU SEE THE 1499 01:25:54,280 --> 01:25:56,320 FLAVOR OF WHAT THE INFORMATION 1500 01:25:56,320 --> 01:25:57,520 LOOKS LIKE. 1501 01:25:57,520 --> 01:25:58,920 THERE'S A PROJECT ON MACHINE 1502 01:25:58,920 --> 01:26:03,080 LEARNING TO IDENTIFY INDIVIDUALS 1503 01:26:03,080 --> 01:26:07,560 WITH AUD AND E.H.R. ANALYSIS FOR 1504 01:26:07,560 --> 01:26:11,360 NON-ALCOHOLIC FATTY LIVER 1505 01:26:11,360 --> 01:26:13,720 DISEASE AND THERE'S GENETIC 1506 01:26:13,720 --> 01:26:20,720 STUDIES LOOKING AT GENETIC UN 1507 01:26:20,720 --> 01:26:21,520 UNDERPINNINGS OF ALCOHOL USE 1508 01:26:21,520 --> 01:26:21,880 DISORDER. 1509 01:26:21,880 --> 01:26:23,440 THESE ARE FEATURES YOU CAN 1510 01:26:23,440 --> 01:26:24,800 SEARCH READILY ON YOUR OWN. 1511 01:26:24,800 --> 01:26:27,120 I JUST WANED TO HIGHLIGHT WHAT 1512 01:26:27,120 --> 01:26:27,840 THINGS LOOK LIKE AS OF A FEW 1513 01:26:27,840 --> 01:26:30,920 DAYS AGO. 1514 01:26:30,920 --> 01:26:32,040 IN THE LAST FEW MINUTES BEFORE 1515 01:26:32,040 --> 01:26:33,280 WE OPEN IT UP FOR DISCUSSION I 1516 01:26:33,280 --> 01:26:35,000 WANT TO TALK ABOUT PARTNERSHIP 1517 01:26:35,000 --> 01:26:35,320 OPPORTUNITIES. 1518 01:26:35,320 --> 01:26:38,040 FIRST I WANT TO HIGHLIGHT THE 1519 01:26:38,040 --> 01:26:39,640 FACT CURRENTLY IN COLLABORATION 1520 01:26:39,640 --> 01:26:42,880 WITH MULTIPLE INSTITUTES AND 1521 01:26:42,880 --> 01:26:48,200 CENTERS ACROSS THE NIH ALL OF US 1522 01:26:48,200 --> 01:26:52,000 HAS AN RO3RFA OUT AND AN R21. 1523 01:26:52,000 --> 01:26:53,960 THE RO3 IS MEANT TO SUPPORT 1524 01:26:53,960 --> 01:26:56,520 ANALYTIC WORK AT THE RESEARCHER 1525 01:26:56,520 --> 01:27:05,720 WORK BENCH AND THE R21 IS ON 1526 01:27:05,720 --> 01:27:10,120 METHODOLOGIC PROPOSALS AND ALL 1527 01:27:10,120 --> 01:27:12,800 OF US IS CALLING FOR 1528 01:27:12,800 --> 01:27:13,720 ADMINISTRATIVE SUPPLEMENTS TO 1529 01:27:13,720 --> 01:27:14,640 PROMOTE WORKFORCE DIVERSITY 1530 01:27:14,640 --> 01:27:16,840 USING OUR DATA SET AND PROBABLY 1531 01:27:16,840 --> 01:27:19,040 LESS RELEVANT TO THIS GROUP A 1532 01:27:19,040 --> 01:27:22,080 CALL FOR A NEW PARTICIPANT AND 1533 01:27:22,080 --> 01:27:23,480 PARTNER SERVICES CENTER A 1534 01:27:23,480 --> 01:27:26,160 PLATFORM OUR PARTICIPANTS 1535 01:27:26,160 --> 01:27:27,240 INTERACT WITH USING APPS ON 1536 01:27:27,240 --> 01:27:29,400 THEIR PHONE OR WEBSITE AND WE'RE 1537 01:27:29,400 --> 01:27:34,680 ALSO ABOUT TO RELEASE A NEW CALL 1538 01:27:34,680 --> 01:27:37,440 FOR CENTER FOR LINKAGES OF 1539 01:27:37,440 --> 01:27:39,400 ACQUISITION OF DATA. 1540 01:27:39,400 --> 01:27:44,680 MAINLY DATA LINKAGES ON 1541 01:27:44,680 --> 01:27:52,160 ENVIRONMENTAL DATA AND OTHER 1542 01:27:52,160 --> 01:27:52,560 UBIQUITOUS DATA. 1543 01:27:52,560 --> 01:27:55,280 LAST YEAR WE AWARDED 1544 01:27:55,280 --> 01:27:56,280 ADMINISTRATIVE SUPPLEMENTS USING 1545 01:27:56,280 --> 01:27:57,240 OUR DATA. 1546 01:27:57,240 --> 01:28:02,320 WE HAD 33 APPLICANTS, 25 WERE 1547 01:28:02,320 --> 01:28:04,680 AWARDED AND YOU CAN SEE SOME 1548 01:28:04,680 --> 01:28:06,440 SELECTED FOR FUNDING AND SOME 1549 01:28:06,440 --> 01:28:08,960 SELECTED IN SUPPORT WITH OUR 1550 01:28:08,960 --> 01:28:10,280 FUNDS AND OTHER RICs OR OTHER 1551 01:28:10,280 --> 01:28:15,440 OFFICES. 1552 01:28:15,440 --> 01:28:17,480 CALLING YOUR ATTENTION TO ONE OF 1553 01:28:17,480 --> 01:28:23,080 THE NOSIS CO-SPONSORED WITH 1554 01:28:23,080 --> 01:28:24,960 NIAAA AROUND VALIDATION STUDY OF 1555 01:28:24,960 --> 01:28:28,600 GENETIC VARIANTS AND PD10 1556 01:28:28,600 --> 01:28:29,920 DETERMINED AT THE U.K. BIO BANK 1557 01:28:29,920 --> 01:28:33,560 DATA SET AND LOOKING AT HOW 1558 01:28:33,560 --> 01:28:34,840 THESE VALIDATE OR DON'T VALIDATE 1559 01:28:34,840 --> 01:28:37,360 IN THE DIVERSITY OF THE 1560 01:28:37,360 --> 01:28:40,280 POPULATION ON THE ALL OF US 1561 01:28:40,280 --> 01:28:49,520 RESEARCH DATA PLATFORM. 1562 01:28:49,520 --> 01:28:52,880 THE GOAL IS TO ENROLL 100 1563 01:28:52,880 --> 01:28:54,240 PARTICIPANTS AND EXPAND THE DATA 1564 01:28:54,240 --> 01:28:56,600 AVAILABLE AND LAUNCH ANCILLARY 1565 01:28:56,600 --> 01:28:58,560 STUDIES AND HAVE 10,000 1566 01:28:58,560 --> 01:29:00,680 RESEARCHERS AT OUR RESEARCHER 1567 01:29:00,680 --> 01:29:02,240 WORK BENCH AND THEN IMPORTANTLY 1568 01:29:02,240 --> 01:29:05,800 TO RETURN VALUE TO OUR 1569 01:29:05,800 --> 01:29:06,120 PARTICIPANTS. 1570 01:29:06,120 --> 01:29:08,480 THE AREA WHERE PARTNERSHIPS 1571 01:29:08,480 --> 01:29:12,040 RESIDE ARE ANCILLARY STUDIES. 1572 01:29:12,040 --> 01:29:14,400 THIS WILL EXPAND OUR DATA SET BY 1573 01:29:14,400 --> 01:29:15,680 ADDING NEW DATA TYPES EITHER 1574 01:29:15,680 --> 01:29:17,360 HAVE BIO SPECIMENS OR 1575 01:29:17,360 --> 01:29:18,000 INFORMATION DIRECTLY GATHERED 1576 01:29:18,000 --> 01:29:19,400 FROM PARTICIPANTS IN THE FORM OF 1577 01:29:19,400 --> 01:29:22,600 SURVEYS OR EVEN IN RECRUITING 1578 01:29:22,600 --> 01:29:24,640 PARTICIPANTS OR ASKING THEM TO 1579 01:29:24,640 --> 01:29:27,160 COME BACK FOR MORE DETAILED 1580 01:29:27,160 --> 01:29:29,520 ANALYSIS OR FIT INTO THE STUDIES 1581 01:29:29,520 --> 01:29:33,000 OR OTHER TYPES OF TRIALS WE 1582 01:29:33,000 --> 01:29:34,560 MIGHT WANT TO HAVE THEM 1583 01:29:34,560 --> 01:29:35,080 PARTICIPATE IN. 1584 01:29:35,080 --> 01:29:37,400 THERE'S A FAIRLY DIVERSE SET OF 1585 01:29:37,400 --> 01:29:40,120 OPPORTUNITIES FOR ANCILLARY 1586 01:29:40,120 --> 01:29:43,360 STUDIES TO AUGMENT THE GROWING 1587 01:29:43,360 --> 01:29:44,280 DATA PLATFORM. 1588 01:29:44,280 --> 01:29:45,880 THIS IS ANOTHER VIEW OF 1589 01:29:45,880 --> 01:29:46,360 ANCILLARY STUDIES. 1590 01:29:46,360 --> 01:29:50,400 THE TRIANGLE OR PYRAMID SHOWS 1591 01:29:50,400 --> 01:29:52,120 FIRST AT THE BOTTOM THE DATA 1592 01:29:52,120 --> 01:29:54,800 WE'RE COLLECTING AT PART OF THE 1593 01:29:54,800 --> 01:29:56,960 CORE PROTOCOL FOR ALL OF US. 1594 01:29:56,960 --> 01:30:03,040 WE'VE HAD THREEAN ANANCE -- TH 1595 01:30:03,040 --> 01:30:05,800 ANCILLARY STUDIES ONE LOOKING AT 1596 01:30:05,800 --> 01:30:07,040 SARS COV2 ANTIBODIES ACROSS OUR 1597 01:30:07,040 --> 01:30:07,320 POPULATION. 1598 01:30:07,320 --> 01:30:10,000 THIS IS A BIO SPECIMEN STUDY 1599 01:30:10,000 --> 01:30:12,520 THAT JUST GENERATES NEW DATA. 1600 01:30:12,520 --> 01:30:18,440 WE LAUNCHED IN DECEMBER WITH ONE 1601 01:30:18,440 --> 01:30:20,600 OF THE OTHER NIH INSTITUTES A 1602 01:30:20,600 --> 01:30:23,680 PROJECT CALLED EXPLORING THE 1603 01:30:23,680 --> 01:30:30,560 MIND BRINGING INDIVIDUALS FOR 1604 01:30:30,560 --> 01:30:32,320 COGNITIVE TESTING USING 1605 01:30:32,320 --> 01:30:34,160 WEARABLES AND SURVEYS AND IN A 1606 01:30:34,160 --> 01:30:35,600 MONTH OR SO WE'LL ENROLL OUR 1607 01:30:35,600 --> 01:30:37,520 FIRST PARTICIPANTS IN A LARGE 1608 01:30:37,520 --> 01:30:39,680 STUDY CALLED NUTRITION FOR 1609 01:30:39,680 --> 01:30:41,920 PRECISION HEALTH WHERE 10,000 1610 01:30:41,920 --> 01:30:44,480 INDIVIDUALS WILL BE RECONTACTED 1611 01:30:44,480 --> 01:30:47,120 AND GIVEN DETAILED DIETARY 1612 01:30:47,120 --> 01:30:49,080 INFORMATION AND HAVE A FEEDING 1613 01:30:49,080 --> 01:30:51,240 STUDY AND A NUMBER OF OTHER 1614 01:30:51,240 --> 01:30:52,400 CHALLENGES TO GIVE OPPORTUNITY 1615 01:30:52,400 --> 01:30:54,880 TO DO INDIVIDUALIZED DIETARY 1616 01:30:54,880 --> 01:30:55,160 ASSESSMENT. 1617 01:30:55,160 --> 01:30:57,280 THE POINT ALSO ON THE RIGHT-HAND 1618 01:30:57,280 --> 01:31:00,080 SIDE IS WE HAVE A RANGE OF 1619 01:31:00,080 --> 01:31:05,760 COMPLEXITY OF THESE STUDIES, BIO 1620 01:31:05,760 --> 01:31:07,680 SPECIMEN OR THE LOWER COMPLEXITY 1621 01:31:07,680 --> 01:31:10,600 STUDIES BUT THE TOP WE'RE OPEN 1622 01:31:10,600 --> 01:31:12,640 TO DOING RANDOMIZED CONTROL 1623 01:31:12,640 --> 01:31:13,400 CLINICAL TRIALS USING THE 1624 01:31:13,400 --> 01:31:15,240 PLATFORM AND OUR PARTICIPANTS AS 1625 01:31:15,240 --> 01:31:16,240 A BASIS FOR ENROLLMENT AND 1626 01:31:16,240 --> 01:31:20,120 RECRUITMENT. 1627 01:31:20,120 --> 01:31:21,840 WE EXPECT OUR ANCILLARY STUDIES 1628 01:31:21,840 --> 01:31:23,520 TO BE SOME WE WANT TO GO AFTER 1629 01:31:23,520 --> 01:31:25,160 BECAUSE THEY ALIGN WITH OUR 1630 01:31:25,160 --> 01:31:27,040 SCIENTIFIC ROAD MAP BUT WE'RE 1631 01:31:27,040 --> 01:31:29,920 ALSO EXPECTING A NUMBER OF ICOs 1632 01:31:29,920 --> 01:31:34,320 AND INSTITUTE AND CENTERS WITH 1633 01:31:34,320 --> 01:31:36,840 REQUEST TO PARTNERSHIP AND THE 1634 01:31:36,840 --> 01:31:38,560 FOCUS AROUND NIH IS HOW THE 1635 01:31:38,560 --> 01:31:40,120 FIRST TWO AREAS FOR ANCILLARY 1636 01:31:40,120 --> 01:31:42,440 STUDIES BUT WANT TO MAKE SURE 1637 01:31:42,440 --> 01:31:43,080 THEY'RE FEASIBLE. 1638 01:31:43,080 --> 01:31:45,040 WE'LL PROBABLY PILOT MOST IN 1639 01:31:45,040 --> 01:31:47,680 SMALL SCALE AND THEN SCALE UP. 1640 01:31:47,680 --> 01:31:50,160 WE ALSO INSIST THEY CONTINUE TO 1641 01:31:50,160 --> 01:31:51,680 ACCRUE VALUE TO OUR PARTICIPANTS 1642 01:31:51,680 --> 01:31:54,720 AND ALSO AS I MENTIONED ALREADY 1643 01:31:54,720 --> 01:31:56,680 ENHANCE OUR OVER ALL DATA 1644 01:31:56,680 --> 01:31:59,560 RESOURCE. 1645 01:31:59,560 --> 01:32:01,600 SO ON THE LAST SLIDE I GUESS IS 1646 01:32:01,600 --> 01:32:03,200 THE MONEY SLIDE FOR THIS 1647 01:32:03,200 --> 01:32:06,000 PARTICULAR DISCUSSION IS HOW CAN 1648 01:32:06,000 --> 01:32:08,400 WE WORK MORE CLOSELY -- HOW CAN 1649 01:32:08,400 --> 01:32:10,600 ALL OF US AT NIAAA WORK MORE 1650 01:32:10,600 --> 01:32:10,800 CLOSELY. 1651 01:32:10,800 --> 01:32:15,400 AS I MENTIONED, WE ALREADY HAVE 1652 01:32:15,400 --> 01:32:16,160 SUBSTANCE USE AND ALCOHOL 1653 01:32:16,160 --> 01:32:18,280 SPECIFIC QUESTIONS IN OUR 1654 01:32:18,280 --> 01:32:18,720 SURVEYS. 1655 01:32:18,720 --> 01:32:20,920 THIS IS ON OUR SCIENTIFIC ROAD 1656 01:32:20,920 --> 01:32:23,480 MAP AND BELIEVE THE AREAS OF 1657 01:32:23,480 --> 01:32:24,920 SUBSTANCE USE AND ALCOHOLISM 1658 01:32:24,920 --> 01:32:27,120 WILL ACTUALLY HAVE AN IMPACT 1659 01:32:27,120 --> 01:32:28,480 ACROSS MANY FOCUS AREAS I'VE 1660 01:32:28,480 --> 01:32:30,000 SHOWED IN THE BRIEF ILLUSTRATION 1661 01:32:30,000 --> 01:32:31,800 OF OUR SCIENTIFIC AGENDA. 1662 01:32:31,800 --> 01:32:35,680 WE THINK THE DIVERSITY OF OUR 1663 01:32:35,680 --> 01:32:38,520 PARTICIPANTS IS A UNIQUE 1664 01:32:38,520 --> 01:32:39,680 OPPORTUNITY MOST LONGITUDINAL 1665 01:32:39,680 --> 01:32:41,800 POPULATIONS STUDIES CANNOT 1666 01:32:41,800 --> 01:32:43,600 AFFORD WITH THE TYPES OF DATA 1667 01:32:43,600 --> 01:32:48,840 WE'RE COLLECTING AND I WANT TO 1668 01:32:48,840 --> 01:32:51,400 EMPHASIZE I INFERRED THE SOCIAL 1669 01:32:51,400 --> 01:32:55,680 DETERMINATES OF HEALTH AND 1670 01:32:55,680 --> 01:32:57,520 ENVIRONMENTAL DATA MIGHT BE VERY 1671 01:32:57,520 --> 01:32:59,640 SYNERGISTIC WITH THE OTHER 1672 01:32:59,640 --> 01:33:01,480 FEATURES AND IMPORTANCE OF 1673 01:33:01,480 --> 01:33:03,480 SUBSTANCE USE OR ABUSE. 1674 01:33:03,480 --> 01:33:06,800 I MENTIONED THE FACT WE HAVE 1675 01:33:06,800 --> 01:33:08,480 MULTI-DIMENSIONAL DATA. 1676 01:33:08,480 --> 01:33:09,920 HOPEFULLY THERE ARE ALREADY 1677 01:33:09,920 --> 01:33:12,200 EXISTING RESEARCH PROGRAMS AND 1678 01:33:12,200 --> 01:33:14,720 STRATEGIES AT NIAAA WE CAN 1679 01:33:14,720 --> 01:33:17,880 FACILITATE THE RAPID DEPLOYMENT 1680 01:33:17,880 --> 01:33:19,640 WITH OUR DATA AND TEST 1681 01:33:19,640 --> 01:33:22,240 HYPOTHESES IN WAYS THAT ARE 1682 01:33:22,240 --> 01:33:24,640 MAYBE NOT ABLE TO TODAY. 1683 01:33:24,640 --> 01:33:27,160 AT THE BOTTOM I KNOW YOU ASKED 1684 01:33:27,160 --> 01:33:31,680 THE QUESTION AND I ATTENDED 1685 01:33:31,680 --> 01:33:40,640 ABOUT THE PHARMACO EPIDEMIOLOGIC 1686 01:33:40,640 --> 01:33:41,800 ACTIVITIES AND YOUR TEAM WAS 1687 01:33:41,800 --> 01:33:45,080 INTERESTED IN MODULATING 1688 01:33:45,080 --> 01:33:46,160 BEHAVIORS AND WE HAVE E.H.R. 1689 01:33:46,160 --> 01:33:49,160 DATA AND WHEN I LOOKED WE HAD 1690 01:33:49,160 --> 01:33:52,880 ABOUT 10,000 USERS OF 1691 01:33:52,880 --> 01:33:56,560 SPIRONOLACTONE AND I SHOWED YOU 1692 01:33:56,560 --> 01:33:58,360 INDIVIDUALS WHO ARE USING 1693 01:33:58,360 --> 01:33:58,640 ALCOHOL. 1694 01:33:58,640 --> 01:34:07,400 WE ALSO HAVE THE TEMPORALITY OF 1695 01:34:07,400 --> 01:34:10,080 THE DATA AND WHEN THEY STARTED 1696 01:34:10,080 --> 01:34:11,680 USING THE MEDICATION. 1697 01:34:11,680 --> 01:34:13,680 THE BASIS IS THERE FOR EXPANSION 1698 01:34:13,680 --> 01:34:15,840 OF THE WORK YOU'VE BEEN DOING IN 1699 01:34:15,840 --> 01:34:18,760 THE AREA OF PHARMACO 1700 01:34:18,760 --> 01:34:21,600 EPIDEMIOLOGY OR LOOKING AT POINT 1701 01:34:21,600 --> 01:34:27,680 OF CARELY OTHER AGENTS AS 1702 01:34:27,680 --> 01:34:30,760 YOYOUR 1703 01:34:30,760 --> 01:34:32,560 TEAM SEES FIT AND I'LL SAY THANK 1704 01:34:32,560 --> 01:34:33,160 YOU AND OPEN THE FLOOR FOR 1705 01:34:33,160 --> 01:34:43,520 QUESTION OR COMMENTS. 1706 01:34:58,800 --> 01:35:02,360 >>WE WERE LOOKING INTO GETTING 1707 01:35:02,360 --> 01:35:03,800 THE AUDIT C PART OF THE TOOLBOX 1708 01:35:03,800 --> 01:35:06,600 FOR THE RECORD. 1709 01:35:06,600 --> 01:35:12,680 AND WIDELY USED AT NIH THAT'S 1710 01:35:12,680 --> 01:35:14,480 WHERE YOU SEE THE BREAKDOWN OF 1711 01:35:14,480 --> 01:35:25,000 SOME THINGS GEOFF ARE ARE MAKE 1712 01:35:26,600 --> 01:35:26,960 GEO 1713 01:35:26,960 --> 01:35:31,120 GEOFFREY IS MAKING. 1714 01:35:31,120 --> 01:35:33,600 YOU MIGHT EVEN CONSIDER 1715 01:35:33,600 --> 01:35:36,240 TELLING -- OR SUGGESTING TO THE 1716 01:35:36,240 --> 01:35:38,680 POWERS -- I DON'T TELL THEM 1717 01:35:38,680 --> 01:35:39,480 ANYTHING, THAT PERHAPS YOU CAN 1718 01:35:39,480 --> 01:35:41,280 RECORD THE SAME TALK FOR THEM. 1719 01:35:41,280 --> 01:35:43,680 ANYWAY, COUNCIL MEMBERS, ANY 1720 01:35:43,680 --> 01:35:46,120 QUESTIONS OR THOUGHTS OR 1721 01:35:46,120 --> 01:35:48,640 COMMENTS? 1722 01:35:48,640 --> 01:35:50,320 I THINK YOU CAN SEE THE 1723 01:35:50,320 --> 01:35:51,680 OPPORTUNITIES HERE ARE 1724 01:35:51,680 --> 01:35:57,680 PRONOUNCED IN MY VIEW. 1725 01:35:57,680 --> 01:36:00,160 THIS IS NOT A COHORT THAT'S 1726 01:36:00,160 --> 01:36:01,160 SCREENED FOR ANYTHING IN 1727 01:36:01,160 --> 01:36:01,440 PARTICULAR. 1728 01:36:01,440 --> 01:36:11,960 THESE ARE FREE-RANGING HUMANS. 1729 01:36:13,680 --> 01:36:15,480 I PERSONALLY THINK THERE'S VALUE 1730 01:36:15,480 --> 01:36:16,160 TO THAT. 1731 01:36:16,160 --> 01:36:19,920 >>THIS IS AN IMPRESSIVE PROJECT 1732 01:36:19,920 --> 01:36:22,120 AND YOU CAN SEE THE GOAL THAT 1733 01:36:22,120 --> 01:36:24,360 CAN COME FROM IT. 1734 01:36:24,360 --> 01:36:25,680 I QUICKLY COVERED A COUPLE 1735 01:36:25,680 --> 01:36:27,680 THINGS AND WONDER IF YOU CAN 1736 01:36:27,680 --> 01:36:30,400 ELABORATE ON WHAT IMAGING AND 1737 01:36:30,400 --> 01:36:34,400 COGNITIVE DATA THE SAMPLE HAS. 1738 01:36:34,400 --> 01:36:36,920 >>I SAID ON IMAGING WE'RE JUST 1739 01:36:36,920 --> 01:36:38,920 GOING AFTER IMAGING. 1740 01:36:38,920 --> 01:36:43,640 E.H.R.s ARE KNNOTORIOUS FOR NOT 1741 01:36:43,640 --> 01:36:44,880 HAVING PRIMARY IMAGING DATA. 1742 01:36:44,880 --> 01:36:48,320 WE'RE TALKING TO SEVERAL OTHER 1743 01:36:48,320 --> 01:36:50,480 NIH INSTITUTES THAT HAVE 1744 01:36:50,480 --> 01:36:55,520 INTEREST IN THINGS LIKE RETINAL 1745 01:36:55,520 --> 01:36:58,560 SCANS AND OTHER TYPES OF MRI 1746 01:36:58,560 --> 01:37:09,040 DATA WE HOPE TO BE ABLE TO 1747 01:37:14,680 --> 01:37:17,680 IMPORT THOSE AND LOOKING AT 1748 01:37:17,680 --> 01:37:19,880 NATURAL LANGUAGE TO CAPTURE THE 1749 01:37:19,880 --> 01:37:25,080 REPORT AND WE'RE LOOKING AT THE 1750 01:37:25,080 --> 01:37:26,640 DATA AND THE OTHER QUESTION? 1751 01:37:26,640 --> 01:37:31,680 >>COGNITIVE TESTING. 1752 01:37:31,680 --> 01:37:39,480 >>THE EXPLORING THE MIND 1753 01:37:39,480 --> 01:37:41,200 PROGRAM I MENTIONED HAS FIVE 1754 01:37:41,200 --> 01:37:42,400 COGNITIVE TESTS THE NAMES OF 1755 01:37:42,400 --> 01:37:44,400 WHICH I'M BLANKING ON BUT CAN 1756 01:37:44,400 --> 01:37:45,240 CERTAINLY SHARE THEM WITH YOU 1757 01:37:45,240 --> 01:37:48,080 AND ALSO IF YOU GO TO THE "ALL 1758 01:37:48,080 --> 01:37:50,200 OF US" WEBSITE I THINK IT WILL 1759 01:37:50,200 --> 01:37:53,040 HAVE THE EXPLORING THE MIND 1760 01:37:53,040 --> 01:37:58,600 PROTOCOL OR AT LEAST SUMMARY OF 1761 01:37:58,600 --> 01:38:01,840 THE PROTOCOL AVAILABLE. 1762 01:38:01,840 --> 01:38:07,680 THE FIRSTANCE ANCE -- FIRST 1763 01:38:07,680 --> 01:38:08,760 ANCILLARY STUDY WILL HAVE AN 1764 01:38:08,760 --> 01:38:11,160 ANALYSIS AND ASSUMING IT'S 1765 01:38:11,160 --> 01:38:13,400 POSITIVE WE HOPE TO SCALE ALL 1766 01:38:13,400 --> 01:38:15,280 FIVE OF THOSE COGNITIVE TESTS TO 1767 01:38:15,280 --> 01:38:18,440 THE ENTIRE COHORT. 1768 01:38:18,440 --> 01:38:21,240 THOSE PARTICIPANTS THAT WOULD 1769 01:38:21,240 --> 01:38:22,640 LIKE TO PARTICIPANT IN THAT. 1770 01:38:22,640 --> 01:38:25,960 WE CAN DO MORE. 1771 01:38:25,960 --> 01:38:27,680 THAT WAS JUST REALLY BROUGHT TO 1772 01:38:27,680 --> 01:38:33,680 US BY NIMH AND WE'RE OPEN TO 1773 01:38:33,680 --> 01:38:34,920 EXPANDING THAT REPERTOIRE OF 1774 01:38:34,920 --> 01:38:39,440 TESTING AS YOU MIGHT SEE FIT. 1775 01:38:39,440 --> 01:38:43,400 >>THANK YOU. 1776 01:38:43,400 --> 01:38:44,160 >>KATIE. 1777 01:38:44,160 --> 01:38:45,120 >>THANK YOU SO MUCH. 1778 01:38:45,120 --> 01:38:46,480 THIS WAS REALLY GREAT. 1779 01:38:46,480 --> 01:38:49,880 I'M SO EXCITED TO SEE THE RFAs 1780 01:38:49,880 --> 01:38:52,000 FOR ANALYSIS OF THIS BECAUSE 1781 01:38:52,000 --> 01:38:52,840 IT'S REALLY A WONDERFUL 1782 01:38:52,840 --> 01:38:53,120 RESOURCE. 1783 01:38:53,120 --> 01:38:56,560 I ALSO WANTED TO SHARE THAT I 1784 01:38:56,560 --> 01:38:59,080 SAW THE ALL OF US VAN ON MY 1785 01:38:59,080 --> 01:38:59,320 CAMPUS. 1786 01:38:59,320 --> 01:39:03,680 SO WE'RE RECRUITING FROM THE 1787 01:39:03,680 --> 01:39:05,080 UNIVERSITY WHICH IS GREAT. 1788 01:39:05,080 --> 01:39:07,520 WE HAVE A WONDERFUL AND DIVERSE 1789 01:39:07,520 --> 01:39:08,560 STUDENT BODY AND FACULTY AND 1790 01:39:08,560 --> 01:39:09,080 STAFF. 1791 01:39:09,080 --> 01:39:10,200 I WAS EXCITED TO SEE THE ALL OF 1792 01:39:10,200 --> 01:39:17,040 US VAN. 1793 01:39:17,040 --> 01:39:21,400 I WANTED TO SHARE THIS AROUND 1794 01:39:21,400 --> 01:39:24,360 LANGUAGE AND NIAAA IS MOVING 1795 01:39:24,360 --> 01:39:25,800 TOWARDS ALCOHOL USE DISORDER AND 1796 01:39:25,800 --> 01:39:27,640 OTHER TERMS THAT ARE 1797 01:39:27,640 --> 01:39:28,840 STIGMATIZING AND IF THEY SHOW UP 1798 01:39:28,840 --> 01:39:30,280 IN YOUR DASHBOARD AND I DON'T 1799 01:39:30,280 --> 01:39:40,800 KNOW HOW TO GET THEM CHANGED. 1800 01:39:45,560 --> 01:39:46,360 JUST WANTED TO SHARE THAT TO GET 1801 01:39:46,360 --> 01:39:49,160 ON BOARD WITH THE LANGUAGE 1802 01:39:49,160 --> 01:39:49,760 EXCHANGES AS WELL. 1803 01:39:49,760 --> 01:39:51,680 >>THANK YOU, AND I'LL SHARE 1804 01:39:51,680 --> 01:39:52,600 THIS WITH MY COLLEAGUES. 1805 01:39:52,600 --> 01:40:01,640 THE DATA I SHOWED YOU WAS 1806 01:40:01,640 --> 01:40:04,160 EXTRACTED FROM ICD10 CODING. 1807 01:40:04,160 --> 01:40:05,240 I DON'T KNOW HOW MUCH YOU HAVE 1808 01:40:05,240 --> 01:40:10,600 AN INFLUENCE ON THAT PART OF OUR 1809 01:40:10,600 --> 01:40:11,680 MEDICAL COMPLEX THAT WAS NOT OUR 1810 01:40:11,680 --> 01:40:13,680 CHOICE BUT WHAT IS IN THE DATA 1811 01:40:13,680 --> 01:40:14,400 SET. 1812 01:40:14,400 --> 01:40:15,240 IT'S A LONGER DISCUSSION WE 1813 01:40:15,240 --> 01:40:16,960 DON'T HAVE TIME FOR BUT I DON'T 1814 01:40:16,960 --> 01:40:27,680 KNOW HOW YOU CHANGE THAT PART. 1815 01:40:27,680 --> 01:40:34,160 >>AND ICD11 IS RELATED TO 1816 01:40:34,160 --> 01:40:38,120 ALCOHOL DEPENDENCE AND THANK YOU 1817 01:40:38,120 --> 01:40:39,680 FOR THAT AND THANK YOU. 1818 01:40:39,680 --> 01:40:49,920 IT WAS GREAT. 1819 01:41:01,200 --> 01:41:06,640 >>THERE ARE MORE WOMEN THAN MEN 1820 01:41:06,640 --> 01:41:17,040 CURRENTLY IN OUR COHORT. 1821 01:42:02,440 --> 01:42:05,920 WE'RE NOT GOING TO BE 1822 01:42:05,920 --> 01:42:06,520 NECESSARILY REPRESENTATIVE OF 1823 01:42:06,520 --> 01:42:07,600 THE U.S. AND I CAN'T FIND THE 1824 01:42:07,600 --> 01:42:08,720 DATA RIGHT NOW. 1825 01:42:08,720 --> 01:42:10,800 >>IT'S NOT WHAT IT'S 1826 01:42:10,800 --> 01:42:12,640 REPRESENTATIVE BUT ARE THE DATA 1827 01:42:12,640 --> 01:42:15,640 IDENTIFIED BY SEX AND PERHAPS 1828 01:42:15,640 --> 01:42:15,880 GENDER? 1829 01:42:15,880 --> 01:42:20,680 DO THE PEOPLE INDICATE WHETHER 1830 01:42:20,680 --> 01:42:21,760 THEY ARE WHICH GENDER THEY 1831 01:42:21,760 --> 01:42:22,880 PREFER TO BE RECOGNIZED BY? 1832 01:42:22,880 --> 01:42:25,800 >>SO THERE'S A COUPLE OF PIECES 1833 01:42:25,800 --> 01:42:27,520 OF THAT. 1834 01:42:27,520 --> 01:42:31,680 IF YOU GO TO -- WHEN YOU GO TO 1835 01:42:31,680 --> 01:42:34,160 THE RESEARCH OR BROWSER, WHEN -- 1836 01:42:34,160 --> 01:42:35,680 LET ME SEE IF I CAN SHARE MY 1837 01:42:35,680 --> 01:42:45,920 SCREEN AGAIN. 1838 01:43:09,280 --> 01:43:19,760 THERE'S CODES USED AND THERE'S 1839 01:43:24,600 --> 01:43:27,480 SEX AND GENDER NOT ON THE 1840 01:43:27,480 --> 01:43:29,680 PUBLICLY FACING TIERS BUT 1841 01:43:29,680 --> 01:43:34,280 ANYBODY CAN GET TO HIGHER ISSUES 1842 01:43:34,280 --> 01:43:35,680 AROUND PRIVACY AND 1843 01:43:35,680 --> 01:43:36,600 CONFIDENTIALITY WHEN IT COMES TO 1844 01:43:36,600 --> 01:43:39,680 THE DATA SET BUT YOU NEED TO 1845 01:43:39,680 --> 01:43:42,920 PASS MODULES LIKE A CITY MODULES 1846 01:43:42,920 --> 01:43:45,560 TO GET TO GREATER ACCESS. 1847 01:43:45,560 --> 01:43:50,880 I JUST WANTED TO SHOW YOU CAN 1848 01:43:50,880 --> 01:43:52,440 SEE RIGHT NOW THE SEX BREAK DOWN 1849 01:43:52,440 --> 01:43:55,240 ON THE FEE IN OUR DATA SET. 1850 01:43:55,240 --> 01:43:59,600 >>PERFECT, THANK YOU. 1851 01:43:59,600 --> 01:44:01,640 >>SO IN THE INTEREST OF TIME WE 1852 01:44:01,640 --> 01:44:06,320 PROBABLY SHOULD MOVE ON. 1853 01:44:06,320 --> 01:44:15,680 >>NOT SURE YOU SAW THE HAND UP. 1854 01:44:15,680 --> 01:44:19,440 >>MY VIDEO SAYS IT'S TURNED OFF 1855 01:44:19,440 --> 01:44:22,000 BY HOST BUT I'M HERE. 1856 01:44:22,000 --> 01:44:26,040 THANK YOU, DR. GINSBURG FOR A 1857 01:44:26,040 --> 01:44:26,600 PHENOMENAL PRESENTATION. 1858 01:44:26,600 --> 01:44:30,040 I'D LIKE TO GO BACK TO A VERY 1859 01:44:30,040 --> 01:44:31,640 EARLY SLIDE WITH YOUR TRIANGLE 1860 01:44:31,640 --> 01:44:33,080 AND ONE OF THE LAST GROUPS YOU 1861 01:44:33,080 --> 01:44:35,680 ADDED IN TOWARDS THE TOP WERE 1862 01:44:35,680 --> 01:44:39,160 THE IMPACT OF HEALTH SYSTEMS AND 1863 01:44:39,160 --> 01:44:39,400 PAYERS. 1864 01:44:39,400 --> 01:44:42,120 AND I'M WONDERING IF YOU CAN 1865 01:44:42,120 --> 01:44:43,320 EXPAND ON THAT A LITTLE BIT MORE 1866 01:44:43,320 --> 01:44:46,160 AND WHAT THAT MEANS IN TERMS OF 1867 01:44:46,160 --> 01:44:47,560 FITTING INTO THE ROAD MAP. 1868 01:44:47,560 --> 01:44:51,240 I ALSO WOULD LIKE TO KNOW IF 1869 01:44:51,240 --> 01:44:53,800 THERE ARE ANY PLANS TO HAVE 1870 01:44:53,800 --> 01:44:56,600 OUTSIDE DATABASES THAT CAN WITH 1871 01:44:56,600 --> 01:44:58,160 INFORMATION THAT DOES AFFECT 1872 01:44:58,160 --> 01:45:00,840 ACCESS TO CARE AND THINGS LIKE 1873 01:45:00,840 --> 01:45:03,760 THAT RELATED TO FINANCING AND 1874 01:45:03,760 --> 01:45:06,160 ORGANIZATIONAL ISSUES. 1875 01:45:06,160 --> 01:45:11,480 >>SO I THINK YOU'RE REFERRING 1876 01:45:11,480 --> 01:45:15,680 TO THE SLIDE OF THE ROAD MAP 1877 01:45:15,680 --> 01:45:15,880 SLIDE. 1878 01:45:15,880 --> 01:45:22,000 >>YES. 1879 01:45:22,000 --> 01:45:23,000 WE ARE PUTTING TOGETHER A 1880 01:45:23,000 --> 01:45:23,760 TRANSLATIONAL WORK STREAM AND 1881 01:45:23,760 --> 01:45:25,760 WORKING GROUP THAT WILL HELP US 1882 01:45:25,760 --> 01:45:28,160 DO THE OUTREACH TO THE KINDS OF 1883 01:45:28,160 --> 01:45:29,800 ORGANIZATIONS THAT ARE GOING TO 1884 01:45:29,800 --> 01:45:32,320 BE NECESSARY TO PARTNER WITH TO 1885 01:45:32,320 --> 01:45:33,320 TRANSLATE OUR RESEARCH BROADLY 1886 01:45:33,320 --> 01:45:33,920 SPEAKING. 1887 01:45:33,920 --> 01:45:35,880 ALL OF US IS A RESEARCH PROGRAM. 1888 01:45:35,880 --> 01:45:37,400 WE ARE NOT A HEALTH SYSTEM. 1889 01:45:37,400 --> 01:45:39,640 WE'RE NOT A HEALTH CARE 1890 01:45:39,640 --> 01:45:39,880 PROVIDER. 1891 01:45:39,880 --> 01:45:41,320 IF WE'RE GOING TO SEE ANY OF THE 1892 01:45:41,320 --> 01:45:45,240 FINDINGS THAT COME OUT FROM OUR 1893 01:45:45,240 --> 01:45:46,200 PERSPECTIVE, WE'RE SEE 1894 01:45:46,200 --> 01:45:48,160 INDIVIDUAL AND POPULATION HEALTH 1895 01:45:48,160 --> 01:45:49,560 IMPACT WE HAVE TO DEVELOP A 1896 01:45:49,560 --> 01:45:51,680 SERIES OF PARTNERSHIPS TO ENABLE 1897 01:45:51,680 --> 01:45:53,960 THAT TO HAPPEN OR FACILITATE 1898 01:45:53,960 --> 01:45:59,680 THEM AND THE NIH HAS MECHANISMS 1899 01:45:59,680 --> 01:46:03,640 LIKE SBIRs BUT WE'LL HAVE TO BE 1900 01:46:03,640 --> 01:46:05,440 MORE STRATEGIC AND I WOULD SAY 1901 01:46:05,440 --> 01:46:11,040 AGGRESSIVE TO MAKE THAT HAPPEN 1902 01:46:11,040 --> 01:46:13,680 BECAUSE OUR GOAL ARE TO 1903 01:46:13,680 --> 01:46:15,680 FACILITATE AND ENABLE THE 1904 01:46:15,680 --> 01:46:21,200 TRANSLATION OF OUR FINDINGS. 1905 01:46:21,200 --> 01:46:24,120 AM I ADDRESSING YOUR QUESTION? 1906 01:46:24,120 --> 01:46:25,320 >>YOU ARE BUT I'M ALSO 1907 01:46:25,320 --> 01:46:27,680 REFERRING TO THE KINDS OF DATA 1908 01:46:27,680 --> 01:46:29,360 THAT MAY BE IN ELECTRONIC HEALTH 1909 01:46:29,360 --> 01:46:31,520 RECORDS THAT ARE MORE ALONG THE 1910 01:46:31,520 --> 01:46:33,520 LINES OF SERVICES RESEARCH AND 1911 01:46:33,520 --> 01:46:35,480 HOW IT'S STRUCTURED. 1912 01:46:35,480 --> 01:46:38,000 YES, I DID HAVE A QUESTION THE 1913 01:46:38,000 --> 01:46:39,600 TRANSLATION PART BUT THE OTHER 1914 01:46:39,600 --> 01:46:44,840 TYPES OF VARIABLES LIKE THAT. 1915 01:46:44,840 --> 01:46:47,280 >>I DIDN'T GO THROUGH THE 1916 01:46:47,280 --> 01:46:49,240 SURVEYS WE ADMINISTERED THAT I 1917 01:46:49,240 --> 01:46:51,040 THINK MIGHT BE RELEVANT TO YOUR 1918 01:46:51,040 --> 01:46:51,280 QUESTION. 1919 01:46:51,280 --> 01:46:55,520 I DID MENTION WE HAVE AN 1920 01:46:55,520 --> 01:46:56,200 EXTENSIVE SOCIAL DETERMINATES OF 1921 01:46:56,200 --> 01:46:58,160 HEALTH DATA THAT WAS RELEASED 1922 01:46:58,160 --> 01:46:58,880 LAST YEAR. 1923 01:46:58,880 --> 01:47:03,640 WE ALSO HAVE HEALTH CARE ACCESS 1924 01:47:03,640 --> 01:47:06,000 AND WE HAVE A LARGE AMOUNT OF 1925 01:47:06,000 --> 01:47:07,680 DATA ON ACCESSIBILITY TO HEALTH 1926 01:47:07,680 --> 01:47:11,280 CARE. 1927 01:47:11,280 --> 01:47:13,840 IF I'M UNDERSTANDING YOUR 1928 01:47:13,840 --> 01:47:15,520 QUESTION, OUR DATA IN THE ONLY 1929 01:47:15,520 --> 01:47:16,440 IS AN OPPORTUNITY FOR RESEARCH 1930 01:47:16,440 --> 01:47:21,560 BUT LAYS THE GROUND WORK FOR US 1931 01:47:21,560 --> 01:47:23,320 TO UNDERSTAND WHERE AND IF WE'RE 1932 01:47:23,320 --> 01:47:24,960 GOING TO TRANSLATE TO DIFFERENT 1933 01:47:24,960 --> 01:47:25,840 HEALTH CARE ENVIRONMENTS WHAT 1934 01:47:25,840 --> 01:47:27,680 MIGHT BE SOME OF THE CHALLENGES 1935 01:47:27,680 --> 01:47:28,560 WE NEED TO ADDRESS UP FRONT IN 1936 01:47:28,560 --> 01:47:35,600 ORDER TO MAKE THAT HAPPEN. 1937 01:47:35,600 --> 01:47:36,120 TWO THINGS. 1938 01:47:36,120 --> 01:47:38,240 ONE I'D LOVE TO HEAR MAYBE 1939 01:47:38,240 --> 01:47:39,680 OFFLINE OR OTHER WAYS YOU THINK 1940 01:47:39,680 --> 01:47:42,800 WE SHOULD BE THINKING ABOUT THIS 1941 01:47:42,800 --> 01:47:44,520 OR I'M HAPPY TO COME BACK AND 1942 01:47:44,520 --> 01:47:47,680 GIVE THE GROUP MORE INFORMATION 1943 01:47:47,680 --> 01:47:49,040 WHEN WE HAVE MORE TRANSLATIONAL 1944 01:47:49,040 --> 01:47:49,840 STRATEGIES IN PLACE. 1945 01:47:49,840 --> 01:47:51,640 >>GREAT. 1946 01:47:51,640 --> 01:48:01,840 THANK YOU. 1947 01:48:13,400 --> 01:48:13,800 >>THANK YOU SO MUCH. 1948 01:48:13,800 --> 01:48:15,640 I THINK WE PROBABLY NEED TO MOVE 1949 01:48:15,640 --> 01:48:18,000 ON BUT I WANT TO EMPHASIZE AGAIN 1950 01:48:18,000 --> 01:48:21,480 IF YOU HAVE FURTHER QUESTIONS 1951 01:48:21,480 --> 01:48:24,760 AND YOU WANT -- I'M SURE YOU CAN 1952 01:48:24,760 --> 01:48:26,680 CONTACT GEOFFREY DIRECTLY BUT IF 1953 01:48:26,680 --> 01:48:28,960 YOU WANT TO FEED THEM THROUGH 1954 01:48:28,960 --> 01:48:31,120 OUR INTERACTION YOU CAN GO 1955 01:48:31,120 --> 01:48:34,640 THROUGH ME OR THROUGH LAURA. 1956 01:48:34,640 --> 01:48:36,920 DAVID, DID YOU HAVE ONE QUICK 1957 01:48:36,920 --> 01:48:37,640 COMMENT. 1958 01:48:37,640 --> 01:48:39,680 >>EXACTLY THAT. 1959 01:48:39,680 --> 01:48:42,760 I WENT TO DR. GINSBURG'S WEBSITE 1960 01:48:42,760 --> 01:48:45,160 TO GET HIS E-MAIL AND IT'S NOT 1961 01:48:45,160 --> 01:48:45,360 THERE. 1962 01:48:45,360 --> 01:48:47,040 IF YOU'RE COMFORTABLE SHARING 1963 01:48:47,040 --> 01:48:48,840 YOUR E-MAIL I'D LOVE TO ASK YOU 1964 01:48:48,840 --> 01:48:49,360 A COMPLICATED QUESTION. 1965 01:48:49,360 --> 01:48:51,400 >>IT'S IN THE CHAT. 1966 01:48:51,400 --> 01:48:55,200 >>THANK YOU. 1967 01:48:55,200 --> 01:48:55,520 >>A PLEASURE. 1968 01:48:55,520 --> 01:48:56,000 >>THANK YOU SO MUCH. 1969 01:48:56,000 --> 01:49:06,240 IT WAS GREAT. 1970 01:49:13,360 --> 01:49:15,680 >>LET ME KNOW ABOUT OTHER 1971 01:49:15,680 --> 01:49:16,240 MEETINGS OUTSIDE THE NIH. 1972 01:49:16,240 --> 01:49:26,440 >>WILL DO. 1973 01:49:32,680 --> 01:49:32,880 OKAY. 1974 01:49:32,880 --> 01:49:34,200 NEXT ON OUR AGENDA ONE OF OUR 1975 01:49:34,200 --> 01:49:44,720 COUNCIL MEMBERS WILL PRESENT. 1976 01:49:55,000 --> 01:49:57,800 I'D LIKE TO INTRODUCE DR. NANCY 1977 01:49:57,800 --> 01:49:59,200 BARNETT A PROFESSOR OF 1978 01:49:59,200 --> 01:50:00,200 BEHAVIORAL AND SOCIAL SCIENCES 1979 01:50:00,200 --> 01:50:01,520 AND PROFESSOR OF PSYCHIATRY AND 1980 01:50:01,520 --> 01:50:03,320 HUMAN BEHAVIOR AT BROWN 1981 01:50:03,320 --> 01:50:04,040 UNIVERSITY. 1982 01:50:04,040 --> 01:50:06,560 SHE'S ALSO ASSOCIATE DEAN FOR 1983 01:50:06,560 --> 01:50:07,800 FACULTY AFFAIRS AT THE SCHOOL OF 1984 01:50:07,800 --> 01:50:10,160 PUBLIC HEALTH RESPONSIBLE FOR 1985 01:50:10,160 --> 01:50:13,200 OVERSEEING FACULTY SEARCHES, 1986 01:50:13,200 --> 01:50:14,640 HIRES AND APPOINTMENTS AND 1987 01:50:14,640 --> 01:50:15,680 SUPPORT CAREER DEVELOPMENT OF 1988 01:50:15,680 --> 01:50:17,640 THE FACULTY IN THE DEPARTMENT OF 1989 01:50:17,640 --> 01:50:19,520 SCHOOL PUBLIC HEALTH. 1990 01:50:19,520 --> 01:50:22,160 HER RESEARCH IS CONDUCTED AT THE 1991 01:50:22,160 --> 01:50:24,480 CENTER FOR ALCOHOL AND ADDICTION 1992 01:50:24,480 --> 01:50:24,760 STUDIES. 1993 01:50:24,760 --> 01:50:26,320 SHE COMPLETED HER GRADUATE 1994 01:50:26,320 --> 01:50:29,160 TRAINING AT THE UNIVERSITY OF 1995 01:50:29,160 --> 01:50:30,240 WASHINGTON AND POST-DOCTORAL 1996 01:50:30,240 --> 01:50:31,280 TRAINING AT BROWN UNIVERSITY. 1997 01:50:31,280 --> 01:50:34,920 HER PRIMARY AREAS OF INTEREST 1998 01:50:34,920 --> 01:50:38,400 ARE DEVELOPING AND TESTING BRIEF 1999 01:50:38,400 --> 01:50:39,480 INVENTIONS FOR YOUNG ADOLESCENTS 2000 01:50:39,480 --> 01:50:40,680 AND YOUNG ADULTS. 2001 01:50:40,680 --> 01:50:42,960 THE INFLUENCE OF ASSOCIATE 2002 01:50:42,960 --> 01:50:46,720 NETWORKS ON ALCOHOL USE AND 2003 01:50:46,720 --> 01:50:48,040 WEARABLE TECHNOLOGY FOR 2004 01:50:48,040 --> 01:50:49,120 ASSESSMENT AND TREATMENT OF 2005 01:50:49,120 --> 01:50:51,160 ALCOHOL USE AND RELATED 2006 01:50:51,160 --> 01:50:51,440 PROBLEMS. 2007 01:50:51,440 --> 01:50:54,400 HER RESEARCH HAS BEEN FUNDED BY 2008 01:50:54,400 --> 01:50:55,440 NIAAA FOR SOME TIME. 2009 01:50:55,440 --> 01:50:57,160 HER RECENT PUBLICATIONS HAVE 2010 01:50:57,160 --> 01:50:59,000 FOCUSSED ON PEER-INFLUENCES 2011 01:50:59,000 --> 01:51:01,120 WITHIN SOCIAL NETWORKS, BEHAVIOR 2012 01:51:01,120 --> 01:51:03,680 CHANGE FOLLOWING ALCOHOL-RELATED 2013 01:51:03,680 --> 01:51:06,440 EXPERIENCES, THE EFFICACY OF 2014 01:51:06,440 --> 01:51:07,120 CONTINGENCY MANAGEMENT FOR 2015 01:51:07,120 --> 01:51:10,040 REDUCING ALCOHOL USE AND THE 2016 01:51:10,040 --> 01:51:11,600 UTILITY OF ALCOHOL BIO SENSORS 2017 01:51:11,600 --> 01:51:13,280 FOR RESEARCH AND CLINICAL 2018 01:51:13,280 --> 01:51:13,560 APPLICATION. 2019 01:51:13,560 --> 01:51:22,520 DR. B BARNETT SERVED ON 2020 01:51:22,520 --> 01:51:25,840 COMMITTEES OR THE CENTER FOR 2021 01:51:25,840 --> 01:51:27,240 REVIEW AND NIAAA AND ON THE 2022 01:51:27,240 --> 01:51:30,880 RESEARCH SOCIETY ON ALCOHOLISM. 2023 01:51:30,880 --> 01:51:34,160 NANCY IS A PERSON I TURN TO WHEN 2024 01:51:34,160 --> 01:51:35,640 I HAVE QUESTIONS IN THESE 2025 01:51:35,640 --> 01:51:35,920 DOMAINS. 2026 01:51:35,920 --> 01:51:40,680 SHE'S DONE PRE PRODIGIOUS 2027 01:51:40,680 --> 01:51:42,240 AMOUNTS OF WORK AND WILL TALK 2028 01:51:42,240 --> 01:51:45,680 ABOUT BIO SENSORS AND STATE OF 2029 01:51:45,680 --> 01:51:47,400 THE SCIENCE AND OPPORTUNITIES 2030 01:51:47,400 --> 01:51:48,440 AND FUTURE DIRECTION. 2031 01:51:48,440 --> 01:51:49,400 IT'S ALL YOURS. 2032 01:51:49,400 --> 01:51:50,840 >>CAN YOU HEAR ME OKAY? 2033 01:51:50,840 --> 01:51:51,520 >>YOU'RE GOOD. 2034 01:51:51,520 --> 01:51:58,160 >>I WANT TO START BY THANKING 2035 01:51:58,160 --> 01:52:02,400 DIRECTOR KOOB FOR INVITING ME. 2036 01:52:02,400 --> 01:52:07,680 I'LL TALK ABOUT ALCOHOL BIO 2037 01:52:07,680 --> 01:52:11,640 SENSORS THAT TRACK ALCOHOL USE 2038 01:52:11,640 --> 01:52:18,520 A 2039 01:52:18,520 --> 01:52:19,600 AND INTERESTING IN LOOKING AT 2040 01:52:19,600 --> 01:52:21,240 THE STATE OF THE SCIENCE AND 2041 01:52:21,240 --> 01:52:22,480 TALKING FIRST ABOUT THE GOALS 2042 01:52:22,480 --> 01:52:24,960 FOR PASSIVE SENSING. 2043 01:52:24,960 --> 01:52:27,560 WHAT WE DO -- WHAT DO WE AS 2044 01:52:27,560 --> 01:52:28,800 RESEARCHERS AND CLINICIANS WANT 2045 01:52:28,800 --> 01:52:30,720 THESE DEVICES TO DO FOR US. 2046 01:52:30,720 --> 01:52:34,160 AND THE PEOPLE WE WORK WITH AND 2047 01:52:34,160 --> 01:52:35,600 RELATEDLY, WHAT FEATURES OF 2048 01:52:35,600 --> 01:52:40,480 THESE DEVICES THAT ARE CURRENTLY 2049 01:52:40,480 --> 01:52:42,280 AVAILABLE FOR USE WHAT ARE THEIR 2050 01:52:42,280 --> 01:52:43,040 LIMITATIONS AND WHAT WE'LL DID 2051 01:52:43,040 --> 01:52:46,040 AND I'LL TALK HOW RESEARCHERS 2052 01:52:46,040 --> 01:52:47,680 ARE ATTEMPTING TO ADDRESS THE 2053 01:52:47,680 --> 01:52:49,640 LIMITATIONS AND THE DEVICES I'M 2054 01:52:49,640 --> 01:52:51,040 AWARE OF COMING DOWN THE 2055 01:52:51,040 --> 01:52:55,680 PIPELINE THAT WE CAN BE LOOKING 2056 01:52:55,680 --> 01:52:58,160 FORWARD TO WORKING WITH. 2057 01:52:58,160 --> 01:52:59,760 SO SHE'S THE GOALS I'VE LAID OUT 2058 01:52:59,760 --> 01:53:03,240 FOR TODAY AND THEY'RE CONSISTENT 2059 01:53:03,240 --> 01:53:08,960 WITH WHAT NIAAA HAS STATED THAT 2060 01:53:08,960 --> 01:53:10,520 NIAAA WOULD EXPECT BIO SENSORS 2061 01:53:10,520 --> 01:53:13,160 WOULD DO IN THEIR CALLS FOR MORE 2062 01:53:13,160 --> 01:53:15,920 WORK IN THIS AREA. 2063 01:53:15,920 --> 01:53:19,720 IT HAS TO BE EXACTABLE TO THE 2064 01:53:19,720 --> 01:53:22,160 WEARER OR YOU GET POOR 2065 01:53:22,160 --> 01:53:22,440 COMPLIANCE. 2066 01:53:22,440 --> 01:53:25,520 THE FORM FACTOR HAS TO BE 2067 01:53:25,520 --> 01:53:27,000 MINIMALLY INVASIVE AND 2068 01:53:27,000 --> 01:53:29,680 ACCEPTABLE AND AFFORDABLE AND 2069 01:53:29,680 --> 01:53:29,880 VALID. 2070 01:53:29,880 --> 01:53:31,640 AND COMPARED TO A GOLD STANDARD 2071 01:53:31,640 --> 01:53:33,280 AND WE'RE INTERESTED TO KNOW 2072 01:53:33,280 --> 01:53:34,160 WHETHER IT CAN DETECT HEAVY 2073 01:53:34,160 --> 01:53:39,680 DRINKING. 2074 01:53:39,680 --> 01:53:44,680 WE NEED TO KNOW WHAT THE BAC IS 2075 01:53:44,680 --> 01:53:46,880 OR PEAK REACH AND TOTAL ALCOHOL 2076 01:53:46,880 --> 01:53:49,520 AKIN TO A NUMBER OF DRINKS 2077 01:53:49,520 --> 01:53:49,800 CONSUMED. 2078 01:53:49,800 --> 01:53:50,800 AND GETTING INFORMATION AND THIS 2079 01:53:50,800 --> 01:53:53,120 IS SOMETHING I'M KIND OF EXCITED 2080 01:53:53,120 --> 01:53:54,960 ABOUT SEEING DEVELOPED, GETTING 2081 01:53:54,960 --> 01:53:56,280 INFORMATION ABOUT THE ALCOHOL 2082 01:53:56,280 --> 01:53:58,160 EPISODE ITSELF. 2083 01:53:58,160 --> 01:54:00,880 THIS IS A STRENGTH OF SENSORS OR 2084 01:54:00,880 --> 01:54:04,160 OTHER MONITORS THAT GET 2085 01:54:04,160 --> 01:54:06,120 CONTINUOUS DATA, THIS TIME 2086 01:54:06,120 --> 01:54:07,880 SERIOUS GIVES US RICH 2087 01:54:07,880 --> 01:54:10,120 INFORMATION AND THE EPISODE 2088 01:54:10,120 --> 01:54:11,800 CHARACTERISTICS SHOULD TELL US 2089 01:54:11,800 --> 01:54:14,840 SOMETHING ABOUT RISK ABOVE PEAK 2090 01:54:14,840 --> 01:54:18,760 LEVEL OF ALCOHOL CONCENTRATION 2091 01:54:18,760 --> 01:54:20,400 RELIABILITY IS KEY AND THEY HAVE 2092 01:54:20,400 --> 01:54:23,240 TO COMPARE WELL, BE STABLE WITH 2093 01:54:23,240 --> 01:54:24,760 FEW FAILURES LEADING TO LOST 2094 01:54:24,760 --> 01:54:26,920 DATA AND FINALLY AND THIS IS A 2095 01:54:26,920 --> 01:54:28,680 KEY POINT AND THE MOST EXCITING 2096 01:54:28,680 --> 01:54:30,120 PART, WE HAVE TO BE ABLE TO 2097 01:54:30,120 --> 01:54:33,360 QUICKLY GET ACCESS TO THE DATA 2098 01:54:33,360 --> 01:54:36,160 FOR WIRELESS TRANSMISSION TO 2099 01:54:36,160 --> 01:54:38,760 SERVERS AND BEING ABLE TO ACCESS 2100 01:54:38,760 --> 01:54:40,960 THE DATA AND ESPECIALLY 2101 01:54:40,960 --> 01:54:42,400 IMPORTANT FOR WIDESPREAD 2102 01:54:42,400 --> 01:54:43,640 ADOPTION WE NEED TOOLS TO HELP 2103 01:54:43,640 --> 01:54:44,240 PEOPLE INTERPRET AND USE THE 2104 01:54:44,240 --> 01:54:47,400 DATA. 2105 01:54:47,400 --> 01:54:51,160 SO THIS IS A TABLE FROM A RECENT 2106 01:54:51,160 --> 01:54:52,680 PAPER THAT REVIEWS AVAILABLE 2107 01:54:52,680 --> 01:54:54,760 DEVICES AND IT HELPS SHOW WHY 2108 01:54:54,760 --> 01:54:55,800 I'M GOING TO PRIMARILY TALK 2109 01:54:55,800 --> 01:54:59,160 ABOUT TWO DEVICES TODAY, THE 2110 01:54:59,160 --> 01:55:00,360 SCRAM AND THE SKIN. 2111 01:55:00,360 --> 01:55:02,480 RIGHT OFF BOTH DEVICES MEASURE 2112 01:55:02,480 --> 01:55:04,200 THE SMALL AMOUNT OF ALCOHOL 2113 01:55:04,200 --> 01:55:06,680 SECRETED THROUGH THE SKIN. 2114 01:55:06,680 --> 01:55:09,600 IT THEN PROVIDES TRANS DERMAL 2115 01:55:09,600 --> 01:55:11,240 ALCOHOL CONCENTRATION. 2116 01:55:11,240 --> 01:55:14,080 THEY'RE BOTH COMMERCIALLY 2117 01:55:14,080 --> 01:55:17,320 AVAILABLE WHEREAS TWO OTHER 2118 01:55:17,320 --> 01:55:19,080 TRANS JOURNAL SENSES ARE NOT 2119 01:55:19,080 --> 01:55:23,840 CURRENTLY AVAILABLE AND THERE 2120 01:55:23,840 --> 01:55:34,320 ARE A FEW AND THERE'S SOME 2121 01:55:35,680 --> 01:55:36,360 COMMERCI 2122 01:55:36,360 --> 01:55:37,720 TESTED BUT NOT COMMERCIALLY 2123 01:55:37,720 --> 01:55:40,360 AVAILABLE YET AND I'M GOING TO 2124 01:55:40,360 --> 01:55:43,040 TALK ABOUT WHAT SOMEONE CAN PICK 2125 01:55:43,040 --> 01:55:44,480 UP IN THEIR LAB AND USE FOR 2126 01:55:44,480 --> 01:55:45,120 RESEARCH AND UNDERSTAND THERE'S 2127 01:55:45,120 --> 01:55:47,800 MORE COMING DOWN THE ROAD. 2128 01:55:47,800 --> 01:55:50,520 FOR THOSE WHO HAVEN'T SEEN THE 2129 01:55:50,520 --> 01:55:56,240 DEVICES THIS IS WHAT THEY LOOK 2130 01:55:56,240 --> 01:55:59,680 LIKE, THE SCRAM IS CONTINUOUS 2131 01:55:59,680 --> 01:56:01,040 MONITORING AND THE SCRAM IS ONE 2132 01:56:01,040 --> 01:56:02,080 ON THE ANKLE. 2133 01:56:02,080 --> 01:56:06,440 IT CAN'T BE REMOVED WITHOUT 2134 01:56:06,440 --> 01:56:09,160 CUTTING THE STRAP OR REMOVING 2135 01:56:09,160 --> 01:56:11,480 THE PLASTIC STRIP. 2136 01:56:11,480 --> 01:56:13,280 THESE ARE FOR PEOPLE COURT 2137 01:56:13,280 --> 01:56:14,960 ORDERED TO WEAR THEM AND A FORM 2138 01:56:14,960 --> 01:56:15,680 OF PROBATION. 2139 01:56:15,680 --> 01:56:16,720 THEY'RE LOCKED ON. 2140 01:56:16,720 --> 01:56:18,480 THEY'RE ALSO USED FOR RESEARCH 2141 01:56:18,480 --> 01:56:19,040 PURPOSES. 2142 01:56:19,040 --> 01:56:22,160 WE'VE HAD GOOD SUCCESS BUT THEY 2143 01:56:22,160 --> 01:56:22,920 ARE LIMITED. 2144 01:56:22,920 --> 01:56:25,520 LIMITED BY ITS APPEARANCE. 2145 01:56:25,520 --> 01:56:32,960 THE SKYN IS REMOVABLE. 2146 01:56:32,960 --> 01:56:37,200 THE SCRAM CAN'T BE SUBMERGED BUT 2147 01:56:37,200 --> 01:56:39,680 YOU CAN SHOWER WITH IT BUT THEY 2148 01:56:39,680 --> 01:56:41,080 SYNC USING DIFFERENT METHODS AND 2149 01:56:41,080 --> 01:56:47,680 THE DATA IS TRANSMITTED AND THE 2150 01:56:47,680 --> 01:56:49,920 SKNY REQUIRES THE PARTICIPANT TO 2151 01:56:49,920 --> 01:56:55,640 OPEN THE APP ON THEIR PHONE AND 2152 01:56:55,640 --> 01:56:57,320 NEITHER ARE GREAT BECAUSE EVERY 2153 01:56:57,320 --> 01:56:59,840 30 MINUTES OF INFORMATION IS NOT 2154 01:56:59,840 --> 01:57:01,680 GRANULAR ENOUGH AND 20 SECONDS 2155 01:57:01,680 --> 01:57:02,840 IS KIND OF TOO OFTEN. 2156 01:57:02,840 --> 01:57:04,960 I'LL SHOW YOU WHAT I MEAN BY 2157 01:57:04,960 --> 01:57:05,160 THAT. 2158 01:57:05,160 --> 01:57:07,680 FOR THOSE WHO HAVE GRADE 2159 01:57:07,680 --> 01:57:09,240 SCHOOLERS WE GIVE THEM A CHECK 2160 01:57:09,240 --> 01:57:11,480 MINUS OR CHECK PLUS FOR 2161 01:57:11,480 --> 01:57:11,800 ACCEPTABILITY. 2162 01:57:11,800 --> 01:57:15,640 THAT'S PRIMARILY FOR THE FORM 2163 01:57:15,640 --> 01:57:21,840 FACTOR. 2164 01:57:21,840 --> 01:57:24,000 HERE'S OUR NEXT SET OF GOALS OF 2165 01:57:24,000 --> 01:57:24,320 VALIDITY. 2166 01:57:24,320 --> 01:57:26,000 I WANTED TO SHOW BY SHOWING WHAT 2167 01:57:26,000 --> 01:57:29,920 THE RAW DATA LOOKS LIKE FROM THE 2168 01:57:29,920 --> 01:57:30,280 DEVICES. 2169 01:57:30,280 --> 01:57:33,600 THEY BOTH GIVE YOU TAC LEVEL. 2170 01:57:33,600 --> 01:57:35,520 THE SCRAM HAS A METRIC WE'RE 2171 01:57:35,520 --> 01:57:39,680 FAMILIAR WITH THE BAC METRIC. 2172 01:57:39,680 --> 01:57:50,160 THE SKYN HAS TIME STAMPS TO 2173 01:57:53,680 --> 01:57:55,080 ALLOW TO MEASURE THE TIME AND WE 2174 01:57:55,080 --> 01:57:57,200 HAVE OTHER INFORMATION WE'RE NOT 2175 01:57:57,200 --> 01:57:58,960 QUITE TO THE POINT WHERE WE'RE 2176 01:57:58,960 --> 01:58:00,880 EFFECTIVELY USING THE OTHER 2177 01:58:00,880 --> 01:58:03,120 SENSORS BUT THERE'S POTENTIAL 2178 01:58:03,120 --> 01:58:03,320 THERE. 2179 01:58:03,320 --> 01:58:05,360 HERE'S WHAT THE SCRAM DATA LOOK 2180 01:58:05,360 --> 01:58:05,720 LIKE. 2181 01:58:05,720 --> 01:58:07,680 NOT ALL CURVES LOOK LIKE THIS 2182 01:58:07,680 --> 01:58:09,160 BUT YOU GET FAIRLY CLEAN DATA 2183 01:58:09,160 --> 01:58:11,120 AND THE TEMPERATURE'S IN RED AND 2184 01:58:11,120 --> 01:58:13,000 THE ORANGE BARS TELL YOU WHEN 2185 01:58:13,000 --> 01:58:15,240 THE PERSON WAS CONSIDERED BY THE 2186 01:58:15,240 --> 01:58:15,880 SCRAM COMPANY TO MEET THEIR 2187 01:58:15,880 --> 01:58:20,080 CRITERIA FOR DRINKING. 2188 01:58:20,080 --> 01:58:21,760 THESE CRITERIA AND I'LL TALK 2189 01:58:21,760 --> 01:58:23,560 ABOUT THESE, THEY'RE A SET OF 2190 01:58:23,560 --> 01:58:24,520 CRITERIA AND THEY GENERALLY HAVE 2191 01:58:24,520 --> 01:58:28,800 TO DO WITH THE MINIMUM LEVEL THE 2192 01:58:28,800 --> 01:58:30,880 TAC HAS HIT BEFORE YOU CONSIDER 2193 01:58:30,880 --> 01:58:34,080 A POSSIBLE EPISODE AND THE SLOPE 2194 01:58:34,080 --> 01:58:37,520 AND THE PEAK AND THE AREA UNDER 2195 01:58:37,520 --> 01:58:39,680 THE CURVE YOU CAN MEASURE THE 2196 01:58:39,680 --> 01:58:41,440 ENTIRE AREA UNDER THE CURVE AND 2197 01:58:41,440 --> 01:58:43,560 LENGTH OF THE EPISODE. 2198 01:58:43,560 --> 01:58:44,920 THERE'S LOTS OF METRICS WE CAN 2199 01:58:44,920 --> 01:58:45,840 PULL FROM THE INFORMATION. 2200 01:58:45,840 --> 01:58:48,320 SOME OF MY WORK HAS SHOWN THE 2201 01:58:48,320 --> 01:58:49,640 CRITERIA FROM THE SCRAM COMPANY 2202 01:58:49,640 --> 01:58:51,200 TO BE TOO STRINGENT FOR OUR 2203 01:58:51,200 --> 01:58:52,160 PURPOSES FOR RESEARCH PURPOSES 2204 01:58:52,160 --> 01:58:53,400 OR CLINICAL PURPOSES. 2205 01:58:53,400 --> 01:58:55,040 THAT'S UNDERSTANDABLE BECAUSE 2206 01:58:55,040 --> 01:58:57,520 THE COMPANY'S BREAD AND BUTTER 2207 01:58:57,520 --> 01:58:59,480 IS PEOPLE WHO ARE MANDATED TO 2208 01:58:59,480 --> 01:59:01,920 WEAR THIS DEVICE AND IF THEY'RE 2209 01:59:01,920 --> 01:59:04,480 CAUGHT DRINKING THEY GO TO JAIL. 2210 01:59:04,480 --> 01:59:07,520 SO FALSE POSITIVES HAVE TO NOT 2211 01:59:07,520 --> 01:59:08,760 HAPPEN. 2212 01:59:08,760 --> 01:59:11,680 FOR US THERE'S MORE COMFORT AND 2213 01:59:11,680 --> 01:59:15,680 MORE TOLERANCE FOR THE LOWER -- 2214 01:59:15,680 --> 01:59:18,800 I CAN ACCEPT SOME FALSE 2215 01:59:18,800 --> 01:59:20,040 POSITIVES TO GET BETTER 2216 01:59:20,040 --> 01:59:22,160 SPECIFICITY AND WE ADJUST THE 2217 01:59:22,160 --> 01:59:27,680 CRITERIA AND THEY FAIR WELL AND 2218 01:59:27,680 --> 01:59:29,640 HAVE BEEN BY MYSELF AND THE SKYN 2219 01:59:29,640 --> 01:59:30,880 DATA NOT SO PRETTY. 2220 01:59:30,880 --> 01:59:33,760 THE VISUAL REFLECTS WHAT WE 2221 01:59:33,760 --> 01:59:35,080 COMMONLY SEE INCLUDING THE SHARP 2222 01:59:35,080 --> 01:59:35,640 PEAKS. 2223 01:59:35,640 --> 01:59:37,520 IT'S UP TO 500. 2224 01:59:37,520 --> 01:59:40,120 YOU SEE A LOT OF JITTER AND 2225 01:59:40,120 --> 01:59:41,120 VALUES BELOW ZERO. 2226 01:59:41,120 --> 01:59:43,280 SO WE HAVE TO DEVELOP WAYS TO 2227 01:59:43,280 --> 01:59:47,080 DEAL WITH THESE ISSUES INCLUDING 2228 01:59:47,080 --> 01:59:48,560 SMOOTHING, RECODING DATA POINTS. 2229 01:59:48,560 --> 01:59:51,120 I'M NOT SO SURE RECODING VALUES 2230 01:59:51,120 --> 01:59:54,320 BELOW ZERO IS THE RIGHT WAY TO 2231 01:59:54,320 --> 01:59:54,480 GO. 2232 01:59:54,480 --> 01:59:56,000 RECODING LOW VALUES TO ZERO IS 2233 01:59:56,000 --> 01:59:58,160 THE WAY TO GO BUT TIME WILL 2234 01:59:58,160 --> 01:59:58,400 TELL. 2235 01:59:58,400 --> 01:59:59,920 THIS IS A GOOD INDICATION OF WHY 2236 01:59:59,920 --> 02:00:03,040 YOU CAN'T JUST PULL THE DATA, 2237 02:00:03,040 --> 02:00:05,480 MAKE DECISIONS ABOUT IT AND USE 2238 02:00:05,480 --> 02:00:07,280 IT IMMEDIATELY TO TELL YOU 2239 02:00:07,280 --> 02:00:08,360 WHETHER THERE'S ALCOHOL CONSUMED 2240 02:00:08,360 --> 02:00:09,320 OR NOT. 2241 02:00:09,320 --> 02:00:11,680 WHEN WE TALK ABOUT VAL TI WE 2242 02:00:11,680 --> 02:00:13,240 HAVE INCREASING EVIDENCE THE 2243 02:00:13,240 --> 02:00:16,160 ABILITY OF SENSORS TO DETECT 2244 02:00:16,160 --> 02:00:20,480 ALCOHOL USE IS QUITE GOOD AND WE 2245 02:00:20,480 --> 02:00:22,160 CHARACTERIZED EVERY SELF-REPORT 2246 02:00:22,160 --> 02:00:25,040 DRINKING EPISODE ADJUSTING THE 2247 02:00:25,040 --> 02:00:26,800 CRITERIA I REFERRED TO AND IT 2248 02:00:26,800 --> 02:00:30,680 INCLUDED RISE, PEAK AND FALL AND 2249 02:00:30,680 --> 02:00:32,000 WE GRAPH THESE A LOT WITH DRINKS 2250 02:00:32,000 --> 02:00:35,640 ALONG THE X AXIS AND THE PERCENT 2251 02:00:35,640 --> 02:00:38,040 OF SELF-REPORTED DRINKING 2252 02:00:38,040 --> 02:00:40,280 EPISODES DETECTED BY TC ON THE Y 2253 02:00:40,280 --> 02:00:40,880 AXIS. 2254 02:00:40,880 --> 02:00:42,200 YOU'LL NOTICE AN INFLECTION 2255 02:00:42,200 --> 02:00:43,680 POINT HERE. 2256 02:00:43,680 --> 02:00:46,920 AT TWO TO THREE DRINKS DETECTION 2257 02:00:46,920 --> 02:00:49,560 AIS QUITE GOOD AND THE TO FOUR 2258 02:00:49,560 --> 02:00:51,680 IS GOOD FOR WOMEN AND BEYOND 2259 02:00:51,680 --> 02:00:53,960 FIVE IT'S VERY GOOD FOR MEN AND 2260 02:00:53,960 --> 02:00:54,160 WOMEN. 2261 02:00:54,160 --> 02:00:56,480 HERE'S THE AREA WE'RE KIND OF 2262 02:00:56,480 --> 02:00:58,200 CONCERNED ABOUT. 2263 02:00:58,200 --> 02:01:06,680 WE CAN'T CONFIDENTLY SAY WE CAN 2264 02:01:06,680 --> 02:01:08,280 DETECT THIS BETWEEN THE DISTANCE 2265 02:01:08,280 --> 02:01:10,800 FROM 0 AND .02 IS SMALL IN 2266 02:01:10,800 --> 02:01:11,440 ENVIRONMENTAL EXPOSURE. 2267 02:01:11,440 --> 02:01:13,240 IT'S MUCH HARDER TO DO THAN YOU 2268 02:01:13,240 --> 02:01:13,760 MIGHT THINK. 2269 02:01:13,760 --> 02:01:16,320 THERE HAS BEEN SOME EFFORT TO DO 2270 02:01:16,320 --> 02:01:19,680 BETTER THAN THIS USING 2271 02:01:19,680 --> 02:01:21,280 ADJUSTMENTS AND RULES. 2272 02:01:21,280 --> 02:01:22,960 I THINK IT'S GOING TO CONTINUE 2273 02:01:22,960 --> 02:01:25,000 TO BE CHALLENGING SIMILAR TO A 2274 02:01:25,000 --> 02:01:27,680 BREATHALYZER TO DETECT ONE DRINK 2275 02:01:27,680 --> 02:01:28,480 MAYBE TWO. 2276 02:01:28,480 --> 02:01:29,760 WITH FIELD DATA WHEN YOU DON'T 2277 02:01:29,760 --> 02:01:31,680 KNOW WHERE TO LOOK FOR THE DATA 2278 02:01:31,680 --> 02:01:35,640 IT'S HARD TO IDENTIFY ONE DRINK. 2279 02:01:35,640 --> 02:01:38,640 THERE'S A LABORATORY-BASED STUDY 2280 02:01:38,640 --> 02:01:45,480 THAT THIS INCLUDES BRAC IN THE 2281 02:01:45,480 --> 02:01:47,680 BLACK AND SCRAM AND SKYN AND HAD 2282 02:01:47,680 --> 02:01:51,680 ALL PARADIGMS. 2283 02:01:51,680 --> 02:01:54,560 THESE ARE FIVE INDIVIDUAL DATA. 2284 02:01:54,560 --> 02:01:58,160 IF YOU LOOK AT THE BRAC IN BLACK 2285 02:01:58,160 --> 02:02:00,320 QUITE STABLE. 2286 02:02:00,320 --> 02:02:10,840 IT LOOKS GOOD AND THERE'S A LOT 2287 02:02:16,440 --> 02:02:20,680 OF VARIABILITY IN THE SCRAM WHEN 2288 02:02:20,680 --> 02:02:25,040 IT SHOULD LOOK LIKE BRAC AND 2289 02:02:25,040 --> 02:02:28,400 WITH SKYN FROM PERSON FIVE TO 25 2290 02:02:28,400 --> 02:02:29,480 THE RED LINES START GETTING 2291 02:02:29,480 --> 02:02:31,200 WONKY NEAR THE END. 2292 02:02:31,200 --> 02:02:32,320 BECAUSE THERE'S VARIABILITY 2293 02:02:32,320 --> 02:02:35,240 BETWEEN PEOPLE, THERE'S GOING TO 2294 02:02:35,240 --> 02:02:36,480 BE VARIABILITY WHEN YOU COMPARE 2295 02:02:36,480 --> 02:02:37,200 DEVICES WITHIN PERSON AND THAT'S 2296 02:02:37,200 --> 02:02:39,680 THE SORT OF THING WE HAVE TO 2297 02:02:39,680 --> 02:02:43,640 GRAPPLE WITH. 2298 02:02:43,640 --> 02:02:46,080 NOW, BOTH OF THESE DEVICES YOU 2299 02:02:46,080 --> 02:02:48,400 CAN SEE HERE, BOTH OF THESE 2300 02:02:48,400 --> 02:02:52,760 DEVICES SHOW A DELAY RELATIVE TO 2301 02:02:52,760 --> 02:02:52,920 TAC. 2302 02:02:52,920 --> 02:02:59,080 THIS IS THE CHARACTERISTIC OF 2303 02:02:59,080 --> 02:03:01,520 TRANS DERMAL USE AND IT CAN BE 2304 02:03:01,520 --> 02:03:03,440 30 MINUTES OR THREE OR FOUR 2305 02:03:03,440 --> 02:03:03,640 HOURS. 2306 02:03:03,640 --> 02:03:07,080 SO THAT'S A FEATURE YOU CAN'T 2307 02:03:07,080 --> 02:03:09,320 JUST APPLY TRANSFORMATION TO OR 2308 02:03:09,320 --> 02:03:14,600 USE A CONSTANT OR ALGORITHM. 2309 02:03:14,600 --> 02:03:18,400 IT'S VARIED SO IT'S NOT EASY TO 2310 02:03:18,400 --> 02:03:19,080 ADJUST TO SAY CONFIDENTLY WHEN 2311 02:03:19,080 --> 02:03:21,160 THE DRINKING BEGAN. 2312 02:03:21,160 --> 02:03:23,640 THIS IS GOOD VISUAL HOW 2313 02:03:23,640 --> 02:03:25,160 CHALLENGING IT IS TO TRANSLATE 2314 02:03:25,160 --> 02:03:26,560 THE TAC AND THE BRAC. 2315 02:03:26,560 --> 02:03:28,160 THE HOLY GRAIL. 2316 02:03:28,160 --> 02:03:30,760 WHAT WE'LL TRY TO KEEP GOING. 2317 02:03:30,760 --> 02:03:31,680 -- KEEP DOING. 2318 02:03:31,680 --> 02:03:34,160 THERE'S BEEN A NUMBER OF LAB 2319 02:03:34,160 --> 02:03:36,320 STUDIES THAT SHOW THE 2320 02:03:36,320 --> 02:03:38,400 CORRELATION BETWEEN PEAK TAC AND 2321 02:03:38,400 --> 02:03:40,800 BRAC AND THE CORRELATION OF 2322 02:03:40,800 --> 02:03:44,920 TOTAL AREA OF THE CURVE AND 2323 02:03:44,920 --> 02:03:46,800 TENDS TO BE GOOD TO VERY GOOD 2324 02:03:46,800 --> 02:03:49,640 AND IN FIELD STUDIES THE AREA 2325 02:03:49,640 --> 02:03:51,200 UNDER THE CURVE CORRELATES WITH 2326 02:03:51,200 --> 02:03:52,760 SELF-REPORTED DRINK. 2327 02:03:52,760 --> 02:03:54,760 YOU GET THE SENSE OF THE 2328 02:03:54,760 --> 02:03:56,800 QUANTITATIVE VALUE THAT IS 2329 02:03:56,800 --> 02:03:57,640 ASSOCIATED WITH HOW MUCH 2330 02:03:57,640 --> 02:04:00,280 SOMEBODY HAS CONSUMED FROM THE 2331 02:04:00,280 --> 02:04:00,880 CURVES. 2332 02:04:00,880 --> 02:04:02,400 NOW, THIS IS A RECENTLY 2333 02:04:02,400 --> 02:04:02,760 PUBLISHED PAPER. 2334 02:04:02,760 --> 02:04:06,760 I'M EXCITED ABOUT THIS BECAUSE 2335 02:04:06,760 --> 02:04:09,880 IT SHOWED THAT WE CAN USE THESE 2336 02:04:09,880 --> 02:04:11,000 CHARACTERISTICS OF THE TIME 2337 02:04:11,000 --> 02:04:12,920 SERIES TO GIVE US INFORMATION 2338 02:04:12,920 --> 02:04:15,880 ABOUT THE RISK A PERSON SHOWED. 2339 02:04:15,880 --> 02:04:17,560 BEYOND ALCOHOL USE INTOXICATION 2340 02:04:17,560 --> 02:04:19,800 AND VOLUME, THE CHARACTERISTICS 2341 02:04:19,800 --> 02:04:23,000 OF THE CURVE AND PRIMARILY I'M 2342 02:04:23,000 --> 02:04:24,480 LOOKING HERE THE FASTER TAC RISE 2343 02:04:24,480 --> 02:04:27,160 AND FALL ARE ASSOCIATED WITH DAY 2344 02:04:27,160 --> 02:04:28,840 LEVEL. 2345 02:04:28,840 --> 02:04:31,480 THESE ARE SINGLE EPISODE DAY 2346 02:04:31,480 --> 02:04:32,840 LEVEL CONSEQUENCES TOTAL NUMBER 2347 02:04:32,840 --> 02:04:34,160 AND INDIVIDUAL SPECIFIC 2348 02:04:34,160 --> 02:04:35,280 CONSEQUENCES LIKE BLACKOUT. 2349 02:04:35,280 --> 02:04:37,080 THIS IS THE VALUE RIGHT. 2350 02:04:37,080 --> 02:04:39,600 THERE'S A LEVEL OF UTILITY WE 2351 02:04:39,600 --> 02:04:42,080 GET WE DON'T GET FROM OCCASIONAL 2352 02:04:42,080 --> 02:04:46,680 BREATH OR SELF-REPORT 2353 02:04:46,680 --> 02:04:47,520 OBSERVATIONS. 2354 02:04:47,520 --> 02:04:49,560 AND WE NEED MORE WORK IN THE 2355 02:04:49,560 --> 02:04:54,400 DATA TO HELP PREDICT WHAT THE 2356 02:04:54,400 --> 02:04:57,680 MORE PROBLEMATIC PATTERNS ARE 2357 02:04:57,680 --> 02:04:58,400 FROM THE SENSOR. 2358 02:04:58,400 --> 02:05:03,640 WE HAVE GOOD ABILITY TO PREDICT 2359 02:05:03,640 --> 02:05:06,160 HEAVY DRINKING AND THERE'S SO 2360 02:05:06,160 --> 02:05:07,680 MUCH VARIABILITY WE CAN'T VERIFY 2361 02:05:07,680 --> 02:05:10,160 THE TIME CONSUMED AND PEAK 2362 02:05:10,160 --> 02:05:11,400 THOUGH SPOILER ALERT THERE'S 2363 02:05:11,400 --> 02:05:16,160 GREAT WORK IN THIS AREA. 2364 02:05:16,160 --> 02:05:17,960 FOR TOTAL EXPOSURE WE'RE USING C 2365 02:05:17,960 --> 02:05:19,280 TO CORRELATE WITH NUMBER OF 2366 02:05:19,280 --> 02:05:19,520 DRINKS. 2367 02:05:19,520 --> 02:05:21,320 THERE'S NO CONVERSION YOU CAN'T 2368 02:05:21,320 --> 02:05:24,960 SAY IT TRANSLATES TO THIS NUMBER 2369 02:05:24,960 --> 02:05:27,160 OF DRINKS BUT THERE'S A 2370 02:05:27,160 --> 02:05:28,640 QUANTITATE VALUE TO COMPARE IN A 2371 02:05:28,640 --> 02:05:31,520 PERSON, CHANGE OVER TIME AND 2372 02:05:31,520 --> 02:05:32,120 BETWEEN PEOPLE ROUGHLY OR IN 2373 02:05:32,120 --> 02:05:37,880 COMPARISON. 2374 02:05:37,880 --> 02:05:41,800 THEN I TALKED ABOUT THE ALCOHOL 2375 02:05:41,800 --> 02:05:42,360 EPISODES. 2376 02:05:42,360 --> 02:05:43,680 I SHOW RELIABILITY ISSUES. 2377 02:05:43,680 --> 02:05:45,000 REMEMBER THE SLIDE FOR FIVE 2378 02:05:45,000 --> 02:05:47,680 CASES IT'S DIFFICULT TO KNOW 2379 02:05:47,680 --> 02:05:50,600 WHETHER THE VARIABILITY YOU SEE 2380 02:05:50,600 --> 02:05:51,920 IS BETWEEN DEVICES. 2381 02:05:51,920 --> 02:05:53,800 YOU PUT A DIFFERENT DEVICE ON 2382 02:05:53,800 --> 02:05:55,680 PERSON A TO PERSON B OR WHETHER 2383 02:05:55,680 --> 02:05:56,360 IT'S INDIVIDUALS. 2384 02:05:56,360 --> 02:06:00,800 I THINK IT'S LIKELY BOTH. 2385 02:06:00,800 --> 02:06:01,920 WE SEE GOOD IMPROVEMENT IN THE 2386 02:06:01,920 --> 02:06:04,920 STABILITY OF DEVICES OVER TIME. 2387 02:06:04,920 --> 02:06:09,240 LESS FAILURE WITH RECENT VERGES. 2388 02:06:09,240 --> 02:06:13,000 WHAT YOU SEE WITH TAC AS IT GETS 2389 02:06:13,000 --> 02:06:13,840 BETTER STABILITY AND RELIABILITY 2390 02:06:13,840 --> 02:06:15,280 GETS BETTER. 2391 02:06:15,280 --> 02:06:17,480 WE SAW IT WITH THE SCRAM AND I 2392 02:06:17,480 --> 02:06:19,840 EXPECT WE'LL SEE IT WITH OTHER 2393 02:06:19,840 --> 02:06:20,080 DEVICES. 2394 02:06:20,080 --> 02:06:21,920 WE EXPECT THAT TO CONTINUE TO 2395 02:06:21,920 --> 02:06:22,920 IMPROVE AND THERE'S EVIDENCE IT 2396 02:06:22,920 --> 02:06:24,240 HAS WITH THE FEW YEARS WE'VE HAD 2397 02:06:24,240 --> 02:06:31,000 THE SKIN FOR RESEARCH PURPOSES. 2398 02:06:31,000 --> 02:06:34,520 ASK NOW GOALS FOR DATA 2399 02:06:34,520 --> 02:06:36,000 INTERPRETATION AND WE HAVE TO BE 2400 02:06:36,000 --> 02:06:37,240 ABLE TO HAVE ACCESS THE DATA 2401 02:06:37,240 --> 02:06:39,080 QUICKLY AND PROCESS THE DATA 2402 02:06:39,080 --> 02:06:39,400 QUICKLY. 2403 02:06:39,400 --> 02:06:41,560 THAT'S NO SMALL FEAT AND WE NEED 2404 02:06:41,560 --> 02:06:43,640 MEANINGFUL OUTPUT WE CAN 2405 02:06:43,640 --> 02:06:45,640 INTERPRET. 2406 02:06:45,640 --> 02:06:50,320 THERE ARE ELEMENTS THAT MAKE THE 2407 02:06:50,320 --> 02:06:55,680 WORK CHALLENGING AND 2408 02:06:55,680 --> 02:06:57,320 ENVIRONMENTAL ARE THINGS LIKE 2409 02:06:57,320 --> 02:07:03,680 HAND SANITIZER, OTHER PRODUCTS 2410 02:07:03,680 --> 02:07:06,800 WITH ALCOHOL IN THEM AND SPILLED 2411 02:07:06,800 --> 02:07:07,600 DRINKS. 2412 02:07:07,600 --> 02:07:10,720 THIS IS ON YOUR ARM AND SO WITH 2413 02:07:10,720 --> 02:07:13,160 THE SCRAM WE STILL SEE 2414 02:07:13,160 --> 02:07:13,520 INTERFERENCE. 2415 02:07:13,520 --> 02:07:15,480 THE TOP FIGURE SHOWS THIS OVER 2416 02:07:15,480 --> 02:07:16,000 MULTIPLE DAYS. 2417 02:07:16,000 --> 02:07:19,200 THE VERTICAL LINE IS DAY BREAK, 2418 02:07:19,200 --> 02:07:20,040 THE BLUE LINES THE TAC. 2419 02:07:20,040 --> 02:07:23,120 YOU CAN SEE THEY GET UP QUITE 2420 02:07:23,120 --> 02:07:28,600 HIGH, 500 AND 600. 2421 02:07:28,600 --> 02:07:32,560 THIS FIGURE SHOWS SPIKES DURING 2422 02:07:32,560 --> 02:07:34,760 CONSUMPTION EPISODE. 2423 02:07:34,760 --> 02:07:39,200 KNOWING THIS WAS AN ISSUE AND 2424 02:07:39,200 --> 02:07:43,400 WOULD BE WE GATHERED DATA TO 2425 02:07:43,400 --> 02:07:45,240 CHARACTERIZE THE CURVES AND YOU 2426 02:07:45,240 --> 02:07:47,000 SEE WHAT HAS TO DO WITH THE 2427 02:07:47,000 --> 02:07:47,600 ALCOHOL DISSIPATING THROUGH THE 2428 02:07:47,600 --> 02:07:53,040 AIR. 2429 02:07:53,040 --> 02:07:55,320 WE ASKED PARTICIPANTS TO TELL US 2430 02:07:55,320 --> 02:07:57,040 WHETHER THEY USED HAND SANITIZER 2431 02:07:57,040 --> 02:08:00,080 AND THIS IS THEM THROUGH COVID. 2432 02:08:00,080 --> 02:08:01,520 AND ALSO WHILE THEY DRANK. 2433 02:08:01,520 --> 02:08:03,640 AND SO WE SELECTED THOSE 2434 02:08:03,640 --> 02:08:06,160 EPISODES OF KNOWN INTERFERENCE 2435 02:08:06,160 --> 02:08:07,680 THAT DIDN'T OCCUR WITHIN 2436 02:08:07,680 --> 02:08:09,880 CONSUMPTION EPISODES AND 2437 02:08:09,880 --> 02:08:13,920 COMPARED THE CHARACTERISTIC OF 2438 02:08:13,920 --> 02:08:17,680 THE OBSERVED CHARACTERISTICS AND 2439 02:08:17,680 --> 02:08:19,800 THEY WERE OBSERVED AND KNEW WHEN 2440 02:08:19,800 --> 02:08:29,600 THEY DRANK. 2441 02:08:29,600 --> 02:08:31,680 WE WERE ABLE TO DEVELOP A SET OF 2442 02:08:31,680 --> 02:08:34,200 CRITERIA THAT EXCLUDED A 2443 02:08:34,200 --> 02:08:37,440 PERCENTAGE OF THE INTERFERENCE 2444 02:08:37,440 --> 02:08:39,360 AND CATEGORIZE THEM AS 2445 02:08:39,360 --> 02:08:44,040 NOT-CONSUMED ALCOHOL. 2446 02:08:44,040 --> 02:08:49,680 THAT WIS FIRST SHOT AND WE 2447 02:08:49,680 --> 02:08:51,600 SHOULD BE ABLE TO MAP THAT AND 2448 02:08:51,600 --> 02:08:53,440 COME UP WITH THE BEST 2449 02:08:53,440 --> 02:08:55,040 CHARACTERISTIC FOR EXCLUDING 2450 02:08:55,040 --> 02:08:57,520 THOSE SO WE GET BETTER 2451 02:08:57,520 --> 02:08:58,200 IDENTIFICATION OF ALCOHOL 2452 02:08:58,200 --> 02:09:08,400 CONSUMPTION. 2453 02:09:35,480 --> 02:09:38,680 LET'S START WITH THE OBVIOUS 2454 02:09:38,680 --> 02:09:38,880 ISSUE. 2455 02:09:38,880 --> 02:09:40,280 THIS SHOWS MISSING DATA ROUGHLY 2456 02:09:40,280 --> 02:09:42,000 18 HOURS. 2457 02:09:42,000 --> 02:09:42,520 THESE ARE DAY BREAKS. 2458 02:09:42,520 --> 02:09:44,120 THIS IS MIDNIGHT. 2459 02:09:44,120 --> 02:09:45,960 WE HAVE CROSSOVER DURING 2460 02:09:45,960 --> 02:09:49,800 OVERNIGHT THAT HAPPENS WHEN THE 2461 02:09:49,800 --> 02:09:51,680 BRACELET'S TURNED OFF OR LOST 2462 02:09:51,680 --> 02:09:52,680 THE CHARGE OR THE DATA 2463 02:09:52,680 --> 02:09:54,000 COLLECTION MALFUNCTIONS. 2464 02:09:54,000 --> 02:09:56,000 I'M CONCERNED THIS BECAUSE 2465 02:09:56,000 --> 02:09:57,920 HERE'S AN ALCOHOL EPISODE THE 2466 02:09:57,920 --> 02:09:59,040 DAY BEFORE. 2467 02:09:59,040 --> 02:10:01,640 THAT'S IN EVIDENT ALCOHOL 2468 02:10:01,640 --> 02:10:02,960 EPISODE SAME TIME OF DAY AND WE 2469 02:10:02,960 --> 02:10:04,200 HAVE NO DATA. 2470 02:10:04,200 --> 02:10:05,840 THAT COULD BE A MISSED ALCOHOL 2471 02:10:05,840 --> 02:10:06,040 EPISODE. 2472 02:10:06,040 --> 02:10:07,160 IT'S MISSING DATA. 2473 02:10:07,160 --> 02:10:09,720 NOTHING YOU CAN DO. 2474 02:10:09,720 --> 02:10:12,240 THIS IS REALLY A PARTICIPANT 2475 02:10:12,240 --> 02:10:14,880 COMPLIANCE ISSUE. 2476 02:10:14,880 --> 02:10:16,560 ASSUMING IT'S NOT BRACELET 2477 02:10:16,560 --> 02:10:17,560 MALFUNCTION. 2478 02:10:17,560 --> 02:10:21,440 TEACHING PARTICIPANTS HOW TO 2479 02:10:21,440 --> 02:10:22,360 CHARGE AND SYNC AND WHAT THEY 2480 02:10:22,360 --> 02:10:24,720 NEED TO DO. 2481 02:10:24,720 --> 02:10:26,560 SO GOOD PRACTICES WITH TRAINING 2482 02:10:26,560 --> 02:10:28,960 PARTICIPANTS AND FOR RESEARCH 2483 02:10:28,960 --> 02:10:31,840 PURPOSES OR FOR ANY PURPOSES, 2484 02:10:31,840 --> 02:10:32,800 RIGHT. 2485 02:10:32,800 --> 02:10:35,080 THE SECOND TYPE OF MISSING DATA 2486 02:10:35,080 --> 02:10:36,240 OR PROBLEMATIC DATA IS MORE 2487 02:10:36,240 --> 02:10:37,320 DIFFICULT. 2488 02:10:37,320 --> 02:10:43,760 THIS IS HIDDEN INVALID DATA. 2489 02:10:43,760 --> 02:10:45,360 YOU HAVE TO IDENTIFY TIMES WHEN 2490 02:10:45,360 --> 02:10:47,800 THE PERSON ISN'T WEARING THE 2491 02:10:47,800 --> 02:10:49,400 BRACELET BUT IT'S NOT TURNED ON 2492 02:10:49,400 --> 02:10:51,040 AND IT'S NOT ON A PERSON SO YOU 2493 02:10:51,040 --> 02:10:51,880 CAN'T TRUST THE TAC. 2494 02:10:51,880 --> 02:10:55,680 THIS IS PART OF THE EPISODE OR 2495 02:10:55,680 --> 02:10:57,720 THIS PERSON'S DATA WHERE 2496 02:10:57,720 --> 02:10:59,280 TEMPERATURE'S VERY LOW. 2497 02:10:59,280 --> 02:11:05,400 IN THIS CASE AT 15 CELSIUS 2498 02:11:05,400 --> 02:11:09,480 THAT'S ROUGHLY 60 FAHRENHEIT. 2499 02:11:09,480 --> 02:11:11,080 WE HAVE LOW TEMP. 2500 02:11:11,080 --> 02:11:15,160 WE CAN PROBABLY IGNORE TAC AND 2501 02:11:15,160 --> 02:11:16,680 IT'S VERY FLAT SO I THINK IT'S 2502 02:11:16,680 --> 02:11:19,800 NOT A PERSON. 2503 02:11:19,800 --> 02:11:20,240 IT'S SITTING STILL. 2504 02:11:20,240 --> 02:11:21,560 THAT'S EIGHT HOURS. 2505 02:11:21,560 --> 02:11:24,120 WE NEED TO CREATE CRITERIA THAT 2506 02:11:24,120 --> 02:11:27,120 ESTABLISHES THIS AS INVALID. 2507 02:11:27,120 --> 02:11:29,240 WE'RE NOT CONFIDENT YET USING 2508 02:11:29,240 --> 02:11:35,640 ANY CRITERION FOR TEMPERATURE. 2509 02:11:35,640 --> 02:11:46,080 THE BAC TRACK COMPANY IS 2510 02:11:47,160 --> 02:11:49,000 CONTACTED AND YOU HAVE DIFFERENT 2511 02:11:49,000 --> 02:11:51,280 TEMPERATURE AND THEY VARY BY 2512 02:11:51,280 --> 02:11:54,280 TIME OF DAY AND SEASON AND 2513 02:11:54,280 --> 02:11:54,560 GEOGRAPHY. 2514 02:11:54,560 --> 02:11:55,240 TEMPERATURE'S GOING TO BE 2515 02:11:55,240 --> 02:11:56,120 TRICKY. 2516 02:11:56,120 --> 02:11:57,440 ULTIMATELY WE SHOULD GET TO A 2517 02:11:57,440 --> 02:11:59,320 POINT WHERE WE HAVE CRITERIA FOR 2518 02:11:59,320 --> 02:12:01,200 DETERMINING THIS IS -- AND THIS 2519 02:12:01,200 --> 02:12:01,600 IS IMPORTANT. 2520 02:12:01,600 --> 02:12:03,600 PEOPLE SAY SO WHAT, THERE'S NO 2521 02:12:03,600 --> 02:12:07,520 DRINKING THERE, RIGHT? 2522 02:12:07,520 --> 02:12:09,320 BUT IT'S ALSO NOT EVIDENCE OF 2523 02:12:09,320 --> 02:12:09,800 NOT DRINKING. 2524 02:12:09,800 --> 02:12:12,680 IF YOU HAVE A PROTOCOL WITH 2525 02:12:12,680 --> 02:12:14,880 OTHER REPORTS AND TRYING TO 2526 02:12:14,880 --> 02:12:15,920 STUDY ALCOHOL CRAVING AND AFFECT 2527 02:12:15,920 --> 02:12:17,320 AND OTHER THINGS YOU'RE TRYING 2528 02:12:17,320 --> 02:12:18,640 TO LEAD WITH AND WANT TO BE ABLE 2529 02:12:18,640 --> 02:12:20,280 TO SAY HERE'S DRINKING AND NOT 2530 02:12:20,280 --> 02:12:22,200 DRINKING, YOU CAN'T BE SURE 2531 02:12:22,200 --> 02:12:27,080 THAT'S NOT DRINKING. 2532 02:12:27,080 --> 02:12:29,080 THAT'S WHAT YOU HAVE TO WORK 2533 02:12:29,080 --> 02:12:29,320 THROUGH. 2534 02:12:29,320 --> 02:12:32,080 WE HAVE DECENT ACCEPTABILITY AND 2535 02:12:32,080 --> 02:12:34,800 GOOD RELIABILITY AND VALIDITY 2536 02:12:34,800 --> 02:12:36,360 BUT WE HAVE ISSUES. 2537 02:12:36,360 --> 02:12:40,600 WE HAVE SOME BIG BUTs AND WE 2538 02:12:40,600 --> 02:12:46,200 HAVE TO DO SOMETHING ABOUT OUR 2539 02:12:46,200 --> 02:12:47,760 BIG BUTs. 2540 02:12:47,760 --> 02:12:49,400 DID YOU LAUGH? 2541 02:12:49,400 --> 02:12:51,640 DID I CRACK YOU UP. 2542 02:12:51,640 --> 02:12:53,040 WE DON'T HAVE ESTABLISHED 2543 02:12:53,040 --> 02:12:55,680 CRITERIA FOR DETECTING ALCOHOL 2544 02:12:55,680 --> 02:12:58,440 USE WITH THE SKYN USING FIELD 2545 02:12:58,440 --> 02:13:00,760 DATA SO WE NEED TO EVALUATE 2546 02:13:00,760 --> 02:13:02,800 DIFFERENT CRITERIA AND USING 2547 02:13:02,800 --> 02:13:04,280 EMPIRICAL METHODS FOR EXCLUDING 2548 02:13:04,280 --> 02:13:09,360 BAD DATA IN THESE TIME SERIES 2549 02:13:09,360 --> 02:13:13,200 AND THE HOLEY GRAIL IS 2550 02:13:13,200 --> 02:13:15,440 TRANSLATING TAC TO BRAC. 2551 02:13:15,440 --> 02:13:16,800 ONE TOOL WE DEVELOPED YEARS AGO 2552 02:13:16,800 --> 02:13:21,400 WITH A TEAM AND PROGRAMMER WAS A 2553 02:13:21,400 --> 02:13:25,960 MACRO THAT WORKS IN EXCEL USING 2554 02:13:25,960 --> 02:13:28,040 VISUAL BASIC AND ALLOWS A USER 2555 02:13:28,040 --> 02:13:29,480 WITH SCRAM TO RUN THE DATA 2556 02:13:29,480 --> 02:13:31,080 THROUGH AND IDENTIFY THE CURVES 2557 02:13:31,080 --> 02:13:32,080 AND CALCULATE SOME 2558 02:13:32,080 --> 02:13:33,480 CHARACTERISTICS FROM THE CURVES. 2559 02:13:33,480 --> 02:13:35,440 WHAT WE NEEDED TO DO IN 2.0 WAS 2560 02:13:35,440 --> 02:13:37,480 TO MAKE IT WORK WITH THE SKYN. 2561 02:13:37,480 --> 02:13:40,520 THE SKYN'S MORE COMPLICATED. 2562 02:13:40,520 --> 02:13:46,160 WE ADDED FEATURES THAT ALLOW US 2563 02:13:46,160 --> 02:13:48,000 TO NOT JUST PRODUCE AREAS 2564 02:13:48,000 --> 02:13:50,680 CRITERIA BUT FIGURE OUTS THE 2565 02:13:50,680 --> 02:13:51,800 CRITERIA WE HAVE TO USE. 2566 02:13:51,800 --> 02:13:55,040 ALSO INCORPORATE EVENT-LEVEL 2567 02:13:55,040 --> 02:13:58,120 DATA IS GREAT WHEN YOU HAVE 2568 02:13:58,120 --> 02:13:59,320 MOMENTARY ASSESSMENT DATA OR 2569 02:13:59,320 --> 02:14:01,960 OTHER OBSERVATIONS YOU WANT TO 2570 02:14:01,960 --> 02:14:02,880 INTERWEAVE THEM BASED ON TIME 2571 02:14:02,880 --> 02:14:04,400 STAMP AND THAT COULD BE 2572 02:14:04,400 --> 02:14:06,120 DIFFICULT FOR EARLIER CAREER 2573 02:14:06,120 --> 02:14:08,480 FOLKS AND YOU WANT TO GET THINGS 2574 02:14:08,480 --> 02:14:11,320 DONE QUICKLY. 2575 02:14:11,320 --> 02:14:12,000 INCORPORATING THOSE EVENT-LEVEL 2576 02:14:12,000 --> 02:14:14,200 DATA ALLOWS US TO MORE QUICKLY 2577 02:14:14,200 --> 02:14:16,200 MAKE CONCLUSIONS ABOUT IT BUT 2578 02:14:16,200 --> 02:14:18,440 EVEN BEFORE THAT IS GOING TO 2579 02:14:18,440 --> 02:14:19,640 ALLOW US TO COMPARE DIFFERENT 2580 02:14:19,640 --> 02:14:25,200 CRITERIA SETS AND COME UP WITH A 2581 02:14:25,200 --> 02:14:26,400 SET THAT WORKS BEST FOR THIS 2582 02:14:26,400 --> 02:14:28,880 TOOL AND THE TOOLS THAT FOLLOW. 2583 02:14:28,880 --> 02:14:31,040 QUICKLY, THIS IS THE CURRENT 2584 02:14:31,040 --> 02:14:31,440 INTERFACE. 2585 02:14:31,440 --> 02:14:36,200 YOU CAN UPLOAD RAW DATA FILES IN 2586 02:14:36,200 --> 02:14:39,640 INDIVIDUALLY OR IN BATCHES, YOU 2587 02:14:39,640 --> 02:14:41,520 CAN ADD EVENT INFORMATION AND 2588 02:14:41,520 --> 02:14:42,640 ADJUST THE EPISODE DETECTION 2589 02:14:42,640 --> 02:14:43,040 CRITERIA. 2590 02:14:43,040 --> 02:14:46,920 THIS IS A TOOL TO HELP US TWEAK 2591 02:14:46,920 --> 02:14:49,760 AND TOGGLE AND TUNE SO THEN GET 2592 02:14:49,760 --> 02:14:51,360 DATA SETS WE CAN COMPARE ANDFIDE 2593 02:14:51,360 --> 02:14:53,160 WHICH ARE THE BEST. 2594 02:14:53,160 --> 02:14:55,200 WE HAVE FILTERS HERE TO FILTER 2595 02:14:55,200 --> 02:14:58,080 OUT THE HIGH PEAKS BECAUSE WE 2596 02:14:58,080 --> 02:15:01,040 THINK THERE'S INTERFERENCE. 2597 02:15:01,040 --> 02:15:03,640 YOU CAN SMITH OR GET NEGATIVE 2598 02:15:03,640 --> 02:15:06,800 VALUES OR ARE ALERTS VERSUS 2599 02:15:06,800 --> 02:15:07,080 FILTERS. 2600 02:15:07,080 --> 02:15:08,720 IT'S EXCITING TO BE ABLE TO HAVE 2601 02:15:08,720 --> 02:15:10,760 THIS TOOL TO SHARE WITH PEOPLE 2602 02:15:10,760 --> 02:15:13,400 WHO ARE USING THE SKYN 2603 02:15:13,400 --> 02:15:14,640 ESPECIALLY BECAUSE TOOLS LIKE 2604 02:15:14,640 --> 02:15:15,480 THIS WILL LOWER THE BAR A LITTLE 2605 02:15:15,480 --> 02:15:17,000 BIT FOR THOSE WHO WANT TO ENTER 2606 02:15:17,000 --> 02:15:17,280 THE SPACE. 2607 02:15:17,280 --> 02:15:21,560 IT'S CHALLENGING. 2608 02:15:21,560 --> 02:15:22,960 YOU LOOK AT THE DATA AND GO WHAT 2609 02:15:22,960 --> 02:15:24,960 DO I DO? 2610 02:15:24,960 --> 02:15:27,400 THE OUTPUT GIVES INTERACTIVE 2611 02:15:27,400 --> 02:15:30,800 GRAPHING AND ENUMERATES THE 2612 02:15:30,800 --> 02:15:33,000 EPISODES OF ALCOHOL AND PUTS 2613 02:15:33,000 --> 02:15:35,640 FLAGS ON THINGS YOU ASK IT TO 2614 02:15:35,640 --> 02:15:37,680 AND VISUALIZE BY EPISODE AND 2615 02:15:37,680 --> 02:15:39,720 DOWNLOAD DATA IN DIFFERENT 2616 02:15:39,720 --> 02:15:42,720 FORMATS AND WIDE OR LONG FOR 2617 02:15:42,720 --> 02:15:44,680 DIFFERENT SOFTWARE PACKAGES. 2618 02:15:44,680 --> 02:15:46,200 IT'S EVERYTHING WE THINK A USER 2619 02:15:46,200 --> 02:15:47,440 WOULD WANT BOTH TO WORK WITH 2620 02:15:47,440 --> 02:15:54,000 THEIR DATA AND FIGURE IT OUT AND 2621 02:15:54,000 --> 02:15:56,160 UNDERSTAND IT, VISUALIZE IT AND 2622 02:15:56,160 --> 02:15:58,200 WANT IT TO BE A FEEDBACK 2623 02:15:58,200 --> 02:16:00,120 MECHANISM AND CREATE A PLATFORM 2624 02:16:00,120 --> 02:16:02,400 FOR PEOPLE USING IT FOR 2625 02:16:02,400 --> 02:16:03,680 SELF-CHANGE OR TREATMENT OR FOR 2626 02:16:03,680 --> 02:16:06,600 PEOPLE TO BE ABLE TO SEE AS 2627 02:16:06,600 --> 02:16:08,800 CLOSE TO REAL TIME AS POSSIBLE 2628 02:16:08,800 --> 02:16:11,640 WHAT THE CONSUMPTION LOOKS LIKE. 2629 02:16:11,640 --> 02:16:14,320 SO ON TO HOW FOLKS ARE 2630 02:16:14,320 --> 02:16:15,680 ADDRESSING THE TAC TO BRAC 2631 02:16:15,680 --> 02:16:16,640 TRANSLATION. 2632 02:16:16,640 --> 02:16:20,200 THIS IS A PAPER FROM 2022 AND 2633 02:16:20,200 --> 02:16:23,120 MOST THE PAPERS ARE REALLY 2634 02:16:23,120 --> 02:16:23,320 RECENT. 2635 02:16:23,320 --> 02:16:24,720 THE PAST FEW YEARS HAS BEEN A 2636 02:16:24,720 --> 02:16:25,760 HOUSE OF FIRE. 2637 02:16:25,760 --> 02:16:26,920 THERE'S GREAT STUFF OUT THERE 2638 02:16:26,920 --> 02:16:30,960 INCLUDING FIVE REVIEWS DONE IN 2639 02:16:30,960 --> 02:16:32,400 2022 ALONE AND TWO IN 2021. 2640 02:16:32,400 --> 02:16:34,600 LOTS OF GREAT STUFF. 2641 02:16:34,600 --> 02:16:36,520 THIS IS A PAPER FROM 2022 2642 02:16:36,520 --> 02:16:38,440 SHOWING MACHINE LEARNING CAN BE 2643 02:16:38,440 --> 02:16:41,320 USED TO CONVERT TAC TO BRAC. 2644 02:16:41,320 --> 02:16:43,720 I HIGHLIGHTED SOME IMPORTANT 2645 02:16:43,720 --> 02:16:45,840 WORK IN THE ABSTRACT. 2646 02:16:45,840 --> 02:16:51,480 BIGGEST STUDY WE'VE HAD OF TRANS 2647 02:16:51,480 --> 02:16:54,040 DERMAL IN THE LAB WITH ALCOHOL 2648 02:16:54,040 --> 02:16:55,040 CONCENTRATION ADMINISTRATION AND 2649 02:16:55,040 --> 02:16:57,640 THE SKYN DEVICE IS DOING BETTER 2650 02:16:57,640 --> 02:17:00,560 AS WE MOVE THROUGH PROTOTYPES 2651 02:17:00,560 --> 02:17:02,760 WE'LL GET BETTER RELIABILITY AND 2652 02:17:02,760 --> 02:17:05,760 THE ESTIMATES FROM BRAC TO TAC 2653 02:17:05,760 --> 02:17:10,200 WERE CLOSE .01 TO .02 OF TRUE 2654 02:17:10,200 --> 02:17:13,120 BRAC READINGS IN THE LAB AND 2655 02:17:13,120 --> 02:17:14,800 FIELD RESPECTIVELY. 2656 02:17:14,800 --> 02:17:16,560 THIS IS GREAT NEWS. 2657 02:17:16,560 --> 02:17:17,440 MACHINE LEARNING WILL BE A GOOD 2658 02:17:17,440 --> 02:17:18,120 TOOL FOR THIS CONVERSION WE HAVE 2659 02:17:18,120 --> 02:17:26,720 TO DO. 2660 02:17:26,720 --> 02:17:30,000 NEXT WE USED PHYSICS AND 2661 02:17:30,000 --> 02:17:32,120 PHYSIOLOGICAL BASED MODELS TO 2662 02:17:32,120 --> 02:17:35,440 CALIBRATE FROM TAC TO AND FIRST 2663 02:17:35,440 --> 02:17:37,600 DOSE AN INDIVIDUAL LOOKING AT 2664 02:17:37,600 --> 02:17:38,600 THE RELATIONSHIP BETWEEN TAC AND 2665 02:17:38,600 --> 02:17:41,400 BRAC AND WHEN YOU SEE JUST TAC 2666 02:17:41,400 --> 02:17:45,280 YOU CAN PREDICT BRAC BUT IT 2667 02:17:45,280 --> 02:17:46,480 REQUIRED A CALIBRATION SYSTEM 2668 02:17:46,480 --> 02:17:52,320 AND NOW THEY'RE REPORTING ON A 2669 02:17:52,320 --> 02:17:52,840 MAGI 2670 02:17:52,840 --> 02:17:56,400 MATHEMATICAL APPROACH AND MAKE 2671 02:17:56,400 --> 02:17:59,200 IT MORE APPLICABLE AND HOPEFULLY 2672 02:17:59,200 --> 02:18:00,160 EASIER TO APPLY. 2673 02:18:00,160 --> 02:18:02,560 LIKE I SAID, CREATE TOOLS THAT 2674 02:18:02,560 --> 02:18:03,440 STANDARDIZE THE PROCESS. 2675 02:18:03,440 --> 02:18:05,080 WHAT WE NEED IS WE NEED TO BE 2676 02:18:05,080 --> 02:18:05,920 BEYOND ALL THIS. 2677 02:18:05,920 --> 02:18:07,760 WE NEED TO BE IN THE PLACE WHERE 2678 02:18:07,760 --> 02:18:09,520 WE HAVE THE DATA AND THE WHAT 2679 02:18:09,520 --> 02:18:11,240 THE DATA'S SAYING AND ALL AGREE 2680 02:18:11,240 --> 02:18:13,680 WE KNOW WHAT THE DATA'S SAYING 2681 02:18:13,680 --> 02:18:16,400 AND CAN TRANSLATE IT AND USE IT 2682 02:18:16,400 --> 02:18:19,640 IN DIFFERENT POPULATIONS WE'RE 2683 02:18:19,640 --> 02:18:21,000 INTERESTED IN. 2684 02:18:21,000 --> 02:18:23,400 SO THERE'S GREAT THINGS IN THE 2685 02:18:23,400 --> 02:18:23,640 PIPELINE. 2686 02:18:23,640 --> 02:18:25,920 ANOTHER TRANS DERMAL SENSOR 2687 02:18:25,920 --> 02:18:28,640 BEING TESTED AND LOOKING FORWARD 2688 02:18:28,640 --> 02:18:31,080 TO HAVING A CHANCE TO WORK WITH 2689 02:18:31,080 --> 02:18:31,360 THAT. 2690 02:18:31,360 --> 02:18:33,440 NOT YET WIDE LIE AVAILABLE AND 2691 02:18:33,440 --> 02:18:35,160 THERE'S TWO OTHERS. 2692 02:18:35,160 --> 02:18:36,600 THERE'S PATCHES. 2693 02:18:36,600 --> 02:18:39,360 YOU CAN LOOK IN THE LITERATURE 2694 02:18:39,360 --> 02:18:44,960 AND PATCHES AND TATTOOS AND A 2695 02:18:44,960 --> 02:18:47,160 SALIVA RING AND SMART GLASSES 2696 02:18:47,160 --> 02:18:48,880 AND MOST ARE IN THE DEVELOPMENT 2697 02:18:48,880 --> 02:18:49,240 PHASE. 2698 02:18:49,240 --> 02:18:51,640 WE HAVE A LOT TO LOOK FORWARD 2699 02:18:51,640 --> 02:18:52,120 TO. 2700 02:18:52,120 --> 02:18:54,160 SOME WORK WAS PRESENTED AT RSA. 2701 02:18:54,160 --> 02:19:01,040 THIS IS A MICRONEEDLE PATCH THAT 2702 02:19:01,040 --> 02:19:03,680 MEASURES ALCOHOL IN THE 2703 02:19:03,680 --> 02:19:05,200 INTERSTITIAL FLUID AND THERE'S 2704 02:19:05,200 --> 02:19:07,160 AN APP THAT CAN COLLECT THE DATA 2705 02:19:07,160 --> 02:19:09,120 AND THAT WAS PROOF OF CONCEPT AN 2706 02:19:09,120 --> 02:19:10,000 SOME FIELD WORK. 2707 02:19:10,000 --> 02:19:13,520 I'M LOOKING FORWARD TO THIS AND 2708 02:19:13,520 --> 02:19:14,840 TO HAVE ANOTHER OPPORTUNITY THAT 2709 02:19:14,840 --> 02:19:20,840 ISN'T EXACTLY THAT BUT CLOSE AND 2710 02:19:20,840 --> 02:19:22,520 UBE BE ABLE TO SEE HOW IT WORKS 2711 02:19:22,520 --> 02:19:23,640 AND THE ACCEPTABILITY. 2712 02:19:23,640 --> 02:19:24,800 THIS IS EXCITING. 2713 02:19:24,800 --> 02:19:27,640 AND THE NEXT THING, THIS IS A 2714 02:19:27,640 --> 02:19:31,160 LITTLE BIT FROM LEFT FIELD BUT 2715 02:19:31,160 --> 02:19:32,680 THERE'S WORK FROM THIS GROUP AND 2716 02:19:32,680 --> 02:19:38,440 THERE'S GREAT VIDEOS ONLINE. 2717 02:19:38,440 --> 02:19:39,640 THEY'RE DEVELOPING A PASSIVE 2718 02:19:39,640 --> 02:19:41,320 BREATH SYSTEM AND TOUCH SYSTEM. 2719 02:19:41,320 --> 02:19:47,680 THE TOUCH SYSTEM IS USING 2720 02:19:47,680 --> 02:19:49,760 OPTICAL SPECTOSCOPY AND WHEN YOU 2721 02:19:49,760 --> 02:19:52,520 PUSH THE BUTTON ON YOUR CAR TO 2722 02:19:52,520 --> 02:19:53,200 START IT WILL READ THE ALCOHOL 2723 02:19:53,200 --> 02:20:03,000 ON YOUR FINGER THROUGH THE 2724 02:20:03,000 --> 02:20:04,760 BUTTON AND IT WON'T LET THE CAR 2725 02:20:04,760 --> 02:20:06,640 START IF YOU HAVE ALCOHOL ON 2726 02:20:06,640 --> 02:20:08,480 BOARD BUT MORE SOPHISTICATED 2727 02:20:08,480 --> 02:20:11,680 BECAUSE ULTIMATELY -- AND WE CAN 2728 02:20:11,680 --> 02:20:12,760 ONLY DREAM IT WILL BE BUILT INTO 2729 02:20:12,760 --> 02:20:15,680 ALL OF OUR CARS LIKE A SEAT 2730 02:20:15,680 --> 02:20:16,200 BELT. 2731 02:20:16,200 --> 02:20:18,200 THE CAR WON'T WORK IF YOU HAVE 2732 02:20:18,200 --> 02:20:22,960 ALCOHOL ON BOARD. 2733 02:20:22,960 --> 02:20:25,160 THEY'RE TESTING THIS AND VIDEO 2734 02:20:25,160 --> 02:20:27,760 HOW THEY USED TO BE GOOD 2735 02:20:27,760 --> 02:20:31,200 MACHINES AND MINIATURIZED AND 2736 02:20:31,200 --> 02:20:33,200 THEY'RE MAKING PROGRESS AND 2737 02:20:33,200 --> 02:20:35,640 IMPLEMENTED THIS IN OM FLEETS OF 2738 02:20:35,640 --> 02:20:46,080 TRANSPORTATION VEHICLES. 2739 02:20:47,040 --> 02:20:49,480 THE TIME WAS TOO SHORT TO TALK 2740 02:20:49,480 --> 02:20:53,120 ABOUT ALL AND THIS HAS BEEN 2741 02:20:53,120 --> 02:20:54,160 SUCCESSFUL IN THE CRIMINAL 2742 02:20:54,160 --> 02:20:56,520 JUSTICE SYSTEM AND THE POTENTIAL 2743 02:20:56,520 --> 02:20:58,200 FOR REDUCING DRIVING FATALITIES 2744 02:20:58,200 --> 02:21:00,080 IS VERY HIGH BUT THERE'S OTHER 2745 02:21:00,080 --> 02:21:00,280 AREAS. 2746 02:21:00,280 --> 02:21:03,000 WE TESTED IT USING CONTINGENCY 2747 02:21:03,000 --> 02:21:08,760 MANAGEMENT AND MYSELF AND THE 2748 02:21:08,760 --> 02:21:19,280 DOHERTY GROUP AND THERE'S WE 2749 02:21:25,600 --> 02:21:28,640 TRACKED USED AND FOR PEOPLE WHO 2750 02:21:28,640 --> 02:21:29,960 HAVE AN ALCOHOL USE PATTERN 2751 02:21:29,960 --> 02:21:31,680 THAT'S NOT GOOD FOR THEM 2752 02:21:31,680 --> 02:21:33,320 GENERALLY AND A TALKED TO 2753 02:21:33,320 --> 02:21:35,680 COUNSELORS AND TREATMENT 2754 02:21:35,680 --> 02:21:39,200 PROVIDERS THEY SAID THEY THINK 2755 02:21:39,200 --> 02:21:49,720 THEY WOULD WELCOME THE TRACKING. 2756 02:21:55,240 --> 02:21:58,240 AND PEOPLE MAY BE STRUGGLING 2757 02:21:58,240 --> 02:22:00,520 WITH ACCOUNTABILITY, 2758 02:22:00,520 --> 02:22:03,440 INFORMATION, HELP IN RELAPSE 2759 02:22:03,440 --> 02:22:03,760 PREVENTION. 2760 02:22:03,760 --> 02:22:06,680 WE'RE NOT READY FOR JUST IN TIME 2761 02:22:06,680 --> 02:22:07,960 INTERVENTIONS BUT WE'RE HOPING 2762 02:22:07,960 --> 02:22:10,160 SOME WAY THERE WILL BE A WAY TO 2763 02:22:10,160 --> 02:22:11,680 ANTICIPATE SOMEONE'S AT RISK 2764 02:22:11,680 --> 02:22:14,120 BECAUSE OF WHERE THEY ARE OR 2765 02:22:14,120 --> 02:22:15,640 WHAT'S HAPPENING IN THEIR WORLD 2766 02:22:15,640 --> 02:22:17,600 OR PHONE AND COULD THEN WARN AND 2767 02:22:17,600 --> 02:22:18,920 DO IN THE MOMENT INTERVENTIONS. 2768 02:22:18,920 --> 02:22:20,640 THEN OF COURSE THERE'S MEDICAL 2769 02:22:20,640 --> 02:22:22,800 OR OTHER CLINICAL SETTINGS WHERE 2770 02:22:22,800 --> 02:22:25,000 ALCOHOL INTERFERES WITH A 2771 02:22:25,000 --> 02:22:25,880 CONDITION OR TREATMENT. 2772 02:22:25,880 --> 02:22:27,640 ALCOHOL INTERFERES WITH 2773 02:22:27,640 --> 02:22:28,560 MEDICATION ADHERENCE AND 2774 02:22:28,560 --> 02:22:28,800 HEALING. 2775 02:22:28,800 --> 02:22:35,000 THE LIST GOES ON AND ON AND THE 2776 02:22:35,000 --> 02:22:42,640 POTENTIAL EVEN FOR SHORT TIME OF 2777 02:22:42,640 --> 02:22:43,840 MONITORING LIKE PRE OR POST ARE 2778 02:22:43,840 --> 02:22:48,680 VERY GOOD. 2779 02:22:48,680 --> 02:22:52,480 SO I'M OUT OF TIME BUT I WANT TO 2780 02:22:52,480 --> 02:22:56,680 THANK NIAAA FOR INVITING ME AND 2781 02:22:56,680 --> 02:22:58,520 MY SCHOOL BROWN, AND MY CENTER 2782 02:22:58,520 --> 02:23:00,480 FOR ALCOHOL AND ADDICTION 2783 02:23:00,480 --> 02:23:01,280 STUDIES. 2784 02:23:01,280 --> 02:23:02,560 I HAVE INCREDIBLE SCIENTIST 2785 02:23:02,560 --> 02:23:04,160 COLLABORATORS WHO CONTRIBUTED TO 2786 02:23:04,160 --> 02:23:05,320 MY WORK AND SHARED THEIR DATA 2787 02:23:05,320 --> 02:23:07,520 AND INCLUDED ME IN THEIR WORK. 2788 02:23:07,520 --> 02:23:09,320 I WOULD POINT OUT THAT OVER HALF 2789 02:23:09,320 --> 02:23:11,720 THE PEOPLE ON THIS LIST ARE 2790 02:23:11,720 --> 02:23:14,720 EARLY CAREER SCIENTISTS WHO HAVE 2791 02:23:14,720 --> 02:23:16,000 BEEN SUPPORTED THROUGH NIAAA 2792 02:23:16,000 --> 02:23:17,600 THROUGH TRAINING OR CAREER 2793 02:23:17,600 --> 02:23:18,840 AWARDS. 2794 02:23:18,840 --> 02:23:22,560 SO THAT'S FANTASTIC. 2795 02:23:22,560 --> 02:23:26,160 THERE'S AN EARLY ADOPTER THING I 2796 02:23:26,160 --> 02:23:28,120 LOVE TO SEE. 2797 02:23:28,120 --> 02:23:30,600 I'M PLEASED I GET TO WORK WITH 2798 02:23:30,600 --> 02:23:31,640 SMART PEOPLE AND THANK YOU ALL 2799 02:23:31,640 --> 02:23:32,080 FOR LISTENING. 2800 02:23:32,080 --> 02:23:42,160 I'M HAPPY TO TAKE QUESTIONS. 2801 02:23:42,160 --> 02:23:43,200 >>THAT WAS WONDERFUL AND 2802 02:23:43,200 --> 02:23:43,920 FANTASTIC UPDATE ESPECIALLY FOR 2803 02:23:43,920 --> 02:23:54,000 ME. 2804 02:23:57,520 --> 02:24:06,440 AND WE WANTED TO MONITOR ALCOHOL 2805 02:24:06,440 --> 02:24:16,960 AND TOM GENTRY WHO ACTUAL LY 2806 02:24:16,960 --> 02:24:20,160 SHOWED US THE SHOE BOX THEY SHOW 2807 02:24:20,160 --> 02:24:21,840 IN PARTS OF THE GOVERNMENT AND 2808 02:24:21,840 --> 02:24:25,560 YOU PUT YOUR FINGER ON IT AND 2809 02:24:25,560 --> 02:24:31,360 GET YOUR INFRARED SENSOR THAT 2810 02:24:31,360 --> 02:24:32,840 MEASURED BLOOD ALCOHOL. 2811 02:24:32,840 --> 02:24:34,720 I'M NOT AWARE THE CAR SYSTEMS 2812 02:24:34,720 --> 02:24:40,040 WERE PART OF OUR DREAM WHICH 2813 02:24:40,040 --> 02:24:46,240 WOULD BE AN INFRARED SENSOR 2814 02:24:46,240 --> 02:24:47,280 WOULD BE SUBJECT TO LESS 2815 02:24:47,280 --> 02:24:48,040 VARIABLE THAN BLOOD ONES. 2816 02:24:48,040 --> 02:24:58,240 >>I'M WAITING FOR MY APPLE 2817 02:24:58,240 --> 02:24:59,600 WATCH BAND AND THEY'RE DOING -- 2818 02:24:59,600 --> 02:25:00,800 THEY WANTING TESTERS. 2819 02:25:00,800 --> 02:25:05,400 THEY WANT PEOPLE TO HELP TEST. 2820 02:25:05,400 --> 02:25:06,520 I ORDERED ONE. 2821 02:25:06,520 --> 02:25:08,280 I'M GOING TO GIVE IT A SHOT. 2822 02:25:08,280 --> 02:25:09,480 >>GOOD FOR YOU. 2823 02:25:09,480 --> 02:25:15,280 I WANT TO RECOUNT SINCE I LIKE 2824 02:25:15,280 --> 02:25:17,840 TO TELL STORIES THAT WE INVITED 2825 02:25:17,840 --> 02:25:20,160 SCRAM PEOPLE TO MEET WITH US AND 2826 02:25:20,160 --> 02:25:22,240 THEY TOLD US THERE WAS 2827 02:25:22,240 --> 02:25:24,280 ABSOLUTELY NO WAY ON EARTH YOU 2828 02:25:24,280 --> 02:25:25,920 COULD EVER MINIATURIZE THE 2829 02:25:25,920 --> 02:25:26,120 SCRAN. 2830 02:25:26,120 --> 02:25:28,520 >>I TOLD THE CEO AT THE TIME -- 2831 02:25:28,520 --> 02:25:30,560 I WAS THERE, IT WAS AN NIAAA 2832 02:25:30,560 --> 02:25:32,960 MEETING AND I SAID YOU'LL NEVER 2833 02:25:32,960 --> 02:25:34,400 GET RESEARCHERS TO TAKE IT ON 2834 02:25:34,400 --> 02:25:36,880 UNLESS YOU MINIATURIZE IT AND 2835 02:25:36,880 --> 02:25:38,400 THAT'S WHAT THEY WERE SAYING, 2836 02:25:38,400 --> 02:25:39,720 CAN'T YOU MAKE IT BE LIKE A FIT 2837 02:25:39,720 --> 02:25:42,320 BIT OR PUT IT ON MY ARM SORT OF 2838 02:25:42,320 --> 02:25:42,760 THING. 2839 02:25:42,760 --> 02:25:47,080 THAT WAS EVEN BEFORE THE DAYS OF 2840 02:25:47,080 --> 02:25:50,960 FULL-ON iPHONE SMARTPHONES. 2841 02:25:50,960 --> 02:25:54,240 I TOLD THEM THE SAME AND THE CEO 2842 02:25:54,240 --> 02:25:55,920 SAID THAT WOULD COST A MILLION 2843 02:25:55,920 --> 02:25:56,160 DOLLARS. 2844 02:25:56,160 --> 02:25:57,880 >>I HAVE ONE QUESTION AND WANT 2845 02:25:57,880 --> 02:25:59,760 TO SEE IF THERE'S COUNCIL MEMBER 2846 02:25:59,760 --> 02:26:01,400 QUESTIONS AND IT'S OKAY IF WE'RE 2847 02:26:01,400 --> 02:26:02,240 A LITTLE BIT LATE. 2848 02:26:02,240 --> 02:26:05,800 WE'LL BE FINE AND CATCH UP. 2849 02:26:05,800 --> 02:26:10,880 SO MY QUESTION IS HAS ANYONE 2850 02:26:10,880 --> 02:26:13,520 STARTED LOOKING AT A HEAD ON 2851 02:26:13,520 --> 02:26:18,680 HEAD COMPARISON BETWEEN TIME 2852 02:26:18,680 --> 02:26:23,320 LINE FALLBACK AND SAY THE BAK 2853 02:26:23,320 --> 02:26:24,160 TRACK DEVICE? 2854 02:26:24,160 --> 02:26:25,520 >>IT'S COMMON FOR PEOPLE 2855 02:26:25,520 --> 02:26:29,880 STUDYING USING THE SENSOR IN THE 2856 02:26:29,880 --> 02:26:30,080 FIELD. 2857 02:26:30,080 --> 02:26:34,760 YOU HAVE TO USE THE DAILY DIARY 2858 02:26:34,760 --> 02:26:38,280 AND I DID THAT IN MY STUDY AND 2859 02:26:38,280 --> 02:26:43,640 DAILY DIARIES -- I THINK THEY 2860 02:26:43,640 --> 02:26:45,640 ARE FINE MORNING YOU ASK 2861 02:26:45,640 --> 02:26:46,360 SOMEBODY WHEN DID YOU DRINK 2862 02:26:46,360 --> 02:26:48,040 YESTERDAY AND START AND FINISH 2863 02:26:48,040 --> 02:26:50,360 AND YOU CAN ASK IN THE MOMENT 2864 02:26:50,360 --> 02:26:51,680 AND PEOPLE WILL REPORT ON 2865 02:26:51,680 --> 02:26:53,640 ALCOHOL USE IN THE MOMENT BUT 2866 02:26:53,640 --> 02:26:56,400 GET NOT GOOD NEAR THE END AS 2867 02:26:56,400 --> 02:26:57,920 THEY HAD MORE TO DRINK AND 2868 02:26:57,920 --> 02:26:59,000 MISSED A COUPLE DRINKS AND MAY 2869 02:26:59,000 --> 02:27:01,000 NOT BE ABLE TO TELL YOU WHEN 2870 02:27:01,000 --> 02:27:03,080 THEY TOOK THE LAST DRINK. 2871 02:27:03,080 --> 02:27:04,360 YOU CAN ASK WHEN YOU DID YOU 2872 02:27:04,360 --> 02:27:07,120 HAVE THE FIRST SIP OF THE FIRST 2873 02:27:07,120 --> 02:27:08,880 DRINK AND LAST SIP OF THE LAST 2874 02:27:08,880 --> 02:27:09,800 DRINK AND YOU CAN COMPARE WHAT 2875 02:27:09,800 --> 02:27:17,120 THEY SAID TO WHAT YOU SEE. 2876 02:27:17,120 --> 02:27:19,160 TIME LINE I FALLBACK I DON'T 2877 02:27:19,160 --> 02:27:27,160 LIKE BECAUSE WEONCE YOU GET BEHD 2878 02:27:27,160 --> 02:27:29,080 AFTER A WEEK PEOPLE AREN'T VERY 2879 02:27:29,080 --> 02:27:31,160 GOOD AT SAYING WHETHER THEY 2880 02:27:31,160 --> 02:27:35,000 DRANK ON TUESDAY OR WEDNESDAY. 2881 02:27:35,000 --> 02:27:37,400 >>I CAN'T REMEMBER WHAT I ATE A 2882 02:27:37,400 --> 02:27:40,360 WEEK AGO. 2883 02:27:40,360 --> 02:27:43,480 >>YOU END UP WITH A REPORT THAT 2884 02:27:43,480 --> 02:27:45,920 SAYS TUESDAY AND A REPORT ON 2885 02:27:45,920 --> 02:27:46,200 WEDNESDAY. 2886 02:27:46,200 --> 02:27:47,320 DO YOU COMBINE THEM? 2887 02:27:47,320 --> 02:27:49,240 DO YOU BELIEVE ONE AND NOT THE 2888 02:27:49,240 --> 02:27:49,440 OTHER? 2889 02:27:49,440 --> 02:27:51,640 IT'S HARD TO KNOW WHAT IS TRUE. 2890 02:27:51,640 --> 02:27:54,240 I LIKE THE DAILY DIARIES. 2891 02:27:54,240 --> 02:27:56,240 PEOPLE ALSO SEND FOLKS OUT WITH 2892 02:27:56,240 --> 02:28:00,080 THE CHEAP BREATHALYZERS TO GET 2893 02:28:00,080 --> 02:28:02,640 BREATH IN THE FIELD AND YOU HAVE 2894 02:28:02,640 --> 02:28:03,520 THE SKIN. 2895 02:28:03,520 --> 02:28:06,200 YOU GET A LITTLE BIT MORE 2896 02:28:06,200 --> 02:28:07,520 ECOLOGICAL VALIDITY WITH THE 2897 02:28:07,520 --> 02:28:09,360 SKIN VERSUS THE LAB BECAUSE YOU 2898 02:28:09,360 --> 02:28:11,280 CAN'T DOSE PEOPLE UP TO HIGH 2899 02:28:11,280 --> 02:28:12,040 LEVELS AND AREN'T GETTING THE 2900 02:28:12,040 --> 02:28:13,360 PAVING OF THEIR DRINKING. 2901 02:28:13,360 --> 02:28:15,080 YOU'RE GETTING THE CONTINUOUS 2902 02:28:15,080 --> 02:28:17,760 WITH THE SKIN AND OCCASIONAL 2903 02:28:17,760 --> 02:28:25,120 VALUE FROM THE BRAC. 2904 02:28:25,120 --> 02:28:27,640 THERE'S GOOD MORE IN THE MOMENT 2905 02:28:27,640 --> 02:28:31,680 AND PREFER THAT TO TIME LINE 2906 02:28:31,680 --> 02:28:32,040 FALLBACK. 2907 02:28:32,040 --> 02:28:33,040 >>GOOD POINT. 2908 02:28:33,040 --> 02:28:34,040 ANYONE FROM COUNCIL HAVE 2909 02:28:34,040 --> 02:28:34,640 QUESTIONS OR COMMENTS? 2910 02:28:34,640 --> 02:28:45,160 I CAN'T SEE ALL THE HANDS SO -- 2911 02:29:23,600 --> 02:29:27,640 WE NEED TO LOOK AT THE PATTERNS 2912 02:29:27,640 --> 02:29:29,000 OF DRINKING. 2913 02:29:29,000 --> 02:29:31,760 AND IT'S OBVIOUS HOW IT CAN 2914 02:29:31,760 --> 02:29:42,120 ADVANCE OUR RESEARCH. 2915 02:29:44,280 --> 02:29:45,720 >>FIVE YEARS FROM NOW WE'LL 2916 02:29:45,720 --> 02:29:48,040 HAVE ANOTHER BATCH OF OPTIONS 2917 02:29:48,040 --> 02:29:50,800 AND AS THINGS GET MINIATURIZED 2918 02:29:50,800 --> 02:29:52,160 WE'LL BE BETTER AT INTERPRETING 2919 02:29:52,160 --> 02:29:54,520 THE DATA WE DO HAVE. 2920 02:29:54,520 --> 02:29:57,120 I'M AN OPTIMIST AND GET EXCITED 2921 02:29:57,120 --> 02:29:58,360 AND GEEKY ABOUT IT BUT I FEEL 2922 02:29:58,360 --> 02:29:59,960 THE SAME AS YOU DO. 2923 02:29:59,960 --> 02:30:01,280 THE OPPORTUNITIES ARE ENDLESS 2924 02:30:01,280 --> 02:30:03,640 WHEN WE COME TO THE APPLICATIONS 2925 02:30:03,640 --> 02:30:14,120 OF THIS SORT OF TECHNOLOGY. 2926 02:30:14,760 --> 02:30:16,760 >>YOU'RE GETTING A LOT OF 2927 02:30:16,760 --> 02:30:17,320 COMMENTS IN THE CHAT. 2928 02:30:17,320 --> 02:30:22,640 WE HAVE TO RETURN TO REALITY, 2929 02:30:22,640 --> 02:30:23,760 EVERYBODY. 2930 02:30:23,760 --> 02:30:27,680 AND WE HAVE MORE DIRE 2931 02:30:27,680 --> 02:30:29,040 PATHOLOGIES ASSOCIATED WITH 2932 02:30:29,040 --> 02:30:29,640 ALCOHOL MISUSE. 2933 02:30:29,640 --> 02:30:34,280 PETER WILL GIVE A CONCEPT 2934 02:30:34,280 --> 02:30:34,560 CLEARANCE. 2935 02:30:34,560 --> 02:30:34,920 IT'S ALL YOURS. 2936 02:30:34,920 --> 02:30:41,080 >>THANK YOU. 2937 02:30:41,080 --> 02:30:45,920 >>MY NAME IS PETER GAO FROM 2938 02:30:45,920 --> 02:30:48,200 METABOLISM AND HEALTHY FAT AT 2939 02:30:48,200 --> 02:30:49,120 NIAAA. 2940 02:30:49,120 --> 02:30:52,400 THIS PRESENTATION IS TO SEEK THE 2941 02:30:52,400 --> 02:30:55,680 COUNCIL'S SUPPORT WITH THE 2942 02:30:55,680 --> 02:30:56,480 PROGRAM. 2943 02:30:56,480 --> 02:31:00,240 TO SET THE STAGE I'LL BEGIN WITH 2944 02:31:00,240 --> 02:31:03,640 BACKGROUND INFORMATION ON 2945 02:31:03,640 --> 02:31:05,080 ALCOHOL ASSOCIATED HEPATITIS AND 2946 02:31:05,080 --> 02:31:10,280 THIS PRESENTATION I MAY ALSO USE 2947 02:31:10,280 --> 02:31:14,720 ALCOHOL HEPATITIS OR AH FOR 2948 02:31:14,720 --> 02:31:18,240 WHICH WILL ASSOCIATED HEPATITIS. 2949 02:31:18,240 --> 02:31:18,880 AS YOU KNOW CHRONIC ALCOHOL USE 2950 02:31:18,880 --> 02:31:22,120 IS ASSOCIATED WITH A RANGE OF 2951 02:31:22,120 --> 02:31:24,080 LIVER DAMAGE FROM FATTY LIVER 2952 02:31:24,080 --> 02:31:28,280 DISEASE TO LIVER FIBROSIS AND 2953 02:31:28,280 --> 02:31:32,400 EVENTUALLY CIRRHOSIS. 2954 02:31:32,400 --> 02:31:37,800 A PERCENTAGE MAY DEVELOP 2955 02:31:37,800 --> 02:31:38,040 CARCINOMA. 2956 02:31:38,040 --> 02:31:41,200 IT'S IMPORTANT TO KNOW THERE'S 2957 02:31:41,200 --> 02:31:43,640 ALCOHOL ASSOCIATED LIVER 2958 02:31:43,640 --> 02:31:46,280 DISEASE. 2959 02:31:46,280 --> 02:31:48,360 IT'S DEFINED AS A CLINICAL 2960 02:31:48,360 --> 02:31:54,520 SYNDROME INCLUDING ACUTE AND 2961 02:31:54,520 --> 02:31:59,240 SEVERE LIVER INJURY. 2962 02:31:59,240 --> 02:32:02,080 SEVERE ALCOHOL HEPATITIS IS ONE 2963 02:32:02,080 --> 02:32:03,560 OF THE MOST SEVERE MANIFEST 2964 02:32:03,560 --> 02:32:07,400 MANIFESTATIONS WITH A 90-DAY 2965 02:32:07,400 --> 02:32:09,720 MORTALITY RATE AROUND 30%. 2966 02:32:09,720 --> 02:32:11,640 CURRENTLY THERE'S NO FDA 2967 02:32:11,640 --> 02:32:14,120 APPROVED DRUG FOR ALCOHOL 2968 02:32:14,120 --> 02:32:14,720 HEPATITIS. 2969 02:32:14,720 --> 02:32:16,280 OPTIONS ONLY INCLUDE SUPPORTIVE 2970 02:32:16,280 --> 02:32:18,840 CARE AND STEROIDS. 2971 02:32:18,840 --> 02:32:21,480 AND UNFORTUNATELY STEROIDS HAVE 2972 02:32:21,480 --> 02:32:23,680 NOT BEEN SHOWN TO IMPROVE 2973 02:32:23,680 --> 02:32:25,360 LONG-TERM SURVIVAL. 2974 02:32:25,360 --> 02:32:27,360 THE ONLY TREATMENT FOR ALCOHOL 2975 02:32:27,360 --> 02:32:29,880 HEPATITIS IS LIVER 2976 02:32:29,880 --> 02:32:30,280 TRANSPLANTATION. 2977 02:32:30,280 --> 02:32:32,840 BUT LIVER TRANSPLANTATION 2978 02:32:32,840 --> 02:32:34,120 REMAINS A SIGNIFICANT CHALLENGE 2979 02:32:34,120 --> 02:32:35,680 DUE TO THE SHORTAGE OF ORGAN 2980 02:32:35,680 --> 02:32:38,160 DONORS. 2981 02:32:38,160 --> 02:32:40,280 THE NUMBER OF ALCOHOL HEPATITIS 2982 02:32:40,280 --> 02:32:43,760 RELATED HOSPITALIZATIONS HAS 2983 02:32:43,760 --> 02:32:45,320 SIGNIFICANTLY INCREASED IN 2984 02:32:45,320 --> 02:32:45,680 RECENT YEARS. 2985 02:32:45,680 --> 02:32:47,600 AND THERE'S MANY REASONS FOR 2986 02:32:47,600 --> 02:32:49,240 THIS INCLUDING THE OVER ALL 2987 02:32:49,240 --> 02:32:51,640 INCREASE IN ALCOHOL CONSUMPTION 2988 02:32:51,640 --> 02:32:56,360 IN RECENT YEARS AND STRESSORS 2989 02:32:56,360 --> 02:32:57,960 SUCH AS COVID-19 EPIDEMIC. 2990 02:32:57,960 --> 02:33:00,440 THEREFORE THERE'S DIRE NEED TO 2991 02:33:00,440 --> 02:33:03,800 DEVELOP SAFE AND EFFECTIVE 2992 02:33:03,800 --> 02:33:04,440 THERAPIES FOR ALCOHOL HEPATITIS 2993 02:33:04,440 --> 02:33:10,280 PATIENTS. 2994 02:33:10,280 --> 02:33:14,400 OTHER THAN THAT WHAT IS HAPPEN 2995 02:33:14,400 --> 02:33:17,760 SINCE 2012 AND THROUGH 2018 THE 2996 02:33:17,760 --> 02:33:19,640 GROWTH INCLUDED A STUDY IN 2997 02:33:19,640 --> 02:33:22,960 DISEASE MECHANISMS AND THERAPIES 2998 02:33:22,960 --> 02:33:27,800 FOR ALCOHOL HEPATITIS. 2999 02:33:27,800 --> 02:33:32,360 AND NIAAA HAS A CLINICAL PROJECT 3000 02:33:32,360 --> 02:33:36,880 TO STUDY ALCOHOL HEPATITIS. 3001 02:33:36,880 --> 02:33:39,480 THE FOCUS HAS SHIFTED TO 3002 02:33:39,480 --> 02:33:42,360 CLINICAL RESEARCH. 3003 02:33:42,360 --> 02:33:43,680 THERE ARE SITES FOR CONDUCTING 3004 02:33:43,680 --> 02:33:54,000 CLINICAL RESEARCH. 3005 02:33:55,480 --> 02:34:03,680 I WOULD LIKE TO TALK ABOUT THE 3006 02:34:03,680 --> 02:34:07,680 ANTAGONIST DRUG APPROVED BY FDA 3007 02:34:07,680 --> 02:34:10,160 FOR TREATING DISEASES AND 3008 02:34:10,160 --> 02:34:12,760 THERE'S AS A PHASE II TRIAL WITH 3009 02:34:12,760 --> 02:34:14,520 PATIENTS WITH SEVERE ALCOHOL 3010 02:34:14,520 --> 02:34:16,040 HEPATITIS. 3011 02:34:16,040 --> 02:34:24,000 PATIENTS WERE RANDOMIZED 1:1. 3012 02:34:24,000 --> 02:34:27,640 AND THE PRIMARY END POINT WAS 90 3013 02:34:27,640 --> 02:34:31,640 DAY SURVIVAL. 3014 02:34:31,640 --> 02:34:35,680 DESPITE THE CHALLENGES DURING 3015 02:34:35,680 --> 02:34:43,680 THE COVID-19 PANDEMIC, THERE WAS 3016 02:34:43,680 --> 02:34:46,840 A STUDY BUT THE TRIAL WAS 3017 02:34:46,840 --> 02:34:49,000 STOPPED AFTER AN INTERIM 3018 02:34:49,000 --> 02:34:50,280 ANALYSIS LAST YEAR. 3019 02:34:50,280 --> 02:34:51,680 THIS INTERIM ANALYSIS SHOWS 3020 02:34:51,680 --> 02:34:56,400 HIGHER OVER ALL SURVIVAL IN THE 3021 02:34:56,400 --> 02:34:58,320 CONTROL ARM AND HIGH INCIDENTS 3022 02:34:58,320 --> 02:35:02,240 IN THE EXPERIMENT ARM. 3023 02:35:02,240 --> 02:35:05,120 NOW I'D LIKE TO LOOK AT THE 3024 02:35:05,120 --> 02:35:09,760 ACHIEVEMENT OF THE TRIAL. 3025 02:35:09,760 --> 02:35:12,840 FIRST, IT DEMONSTRATE THE 3026 02:35:12,840 --> 02:35:16,200 CLINICAL TRILS IN SEVERE 3027 02:35:16,200 --> 02:35:20,480 HEPATITIS AND SUCCESSFUL 3028 02:35:20,480 --> 02:35:21,000 ENROLLMENT. 3029 02:35:21,000 --> 02:35:21,760 SECOND, PUBLISHED DIAGNOSTIC 3030 02:35:21,760 --> 02:35:23,680 CRITERIA AND COMMON DATA 3031 02:35:23,680 --> 02:35:27,040 ELEMENTS TO HARMONIZE CLINICAL 3032 02:35:27,040 --> 02:35:30,080 TRIAL OF WHICH WILL HEPATITIS IN 3033 02:35:30,080 --> 02:35:30,280 2016. 3034 02:35:30,280 --> 02:35:36,320 SINCE THEN THE NUMBER OF ACTIVE 3035 02:35:36,320 --> 02:35:40,280 CLINICAL TRIALS FOR ALCOHOL 3036 02:35:40,280 --> 02:35:41,160 HEPATITIS INCREASED. 3037 02:35:41,160 --> 02:35:43,680 THERE'S ALSO SOME LESSONS OR 3038 02:35:43,680 --> 02:35:47,320 EXPERIMENTS WE CAN LEARN FROM 3039 02:35:47,320 --> 02:35:47,520 THIS. 3040 02:35:47,520 --> 02:35:51,280 THERE'S A HIGHER THAN 90-DAY 3041 02:35:51,280 --> 02:35:58,280 SURVIVAL RATE IN THE PREDNISONE 3042 02:35:58,280 --> 02:36:01,400 CONTROL RATE AND COVID-19 3043 02:36:01,400 --> 02:36:03,360 PANDEMIC MAY HAVE IMPACT ON 3044 02:36:03,360 --> 02:36:07,880 PATIENT ENROLLMENT AND THE 3045 02:36:07,880 --> 02:36:09,200 DIRECTION. 3046 02:36:09,200 --> 02:36:10,280 I'D LIKE TO TALK ABOUT THE 3047 02:36:10,280 --> 02:36:14,120 FUTURE DIRECTION. 3048 02:36:14,120 --> 02:36:15,440 WHEN THINKING ABOUT ALCOHOL 3049 02:36:15,440 --> 02:36:17,120 HEPATITIS IT'S IMPORTANT TO 3050 02:36:17,120 --> 02:36:18,920 APPROACH THIS AS TWO DISEASES. 3051 02:36:18,920 --> 02:36:19,880 ALCOHOL USE DISORDER AND ALCOHOL 3052 02:36:19,880 --> 02:36:23,320 LIVER DISEASE. 3053 02:36:23,320 --> 02:36:28,280 ALCOHOL USE DISORDER OR AUD IS 3054 02:36:28,280 --> 02:36:29,760 CHARACTERIZED BY COMPULSION TO 3055 02:36:29,760 --> 02:36:30,840 CONSUME ALCOHOL. 3056 02:36:30,840 --> 02:36:35,640 THE CONTINUED USE OF ALCOHOL IS 3057 02:36:35,640 --> 02:36:40,040 OFTEN VIEWED AS AUD. 3058 02:36:40,040 --> 02:36:42,240 TREATMENT CAN REDUCE HOSPITAL 3059 02:36:42,240 --> 02:36:46,240 ADMISSION AND ALCOHOL RELAPSE IN 3060 02:36:46,240 --> 02:36:47,680 ALCOHOL HEPATITIS PATIENTS. 3061 02:36:47,680 --> 02:36:51,600 AND IN THE STUDY, IT'S FOUND 3062 02:36:51,600 --> 02:36:55,720 LESS THAN 8% OF AH PATIENTS 3063 02:36:55,720 --> 02:37:00,360 RECEIVED MEDICATION TO PREVENT 3064 02:37:00,360 --> 02:37:01,760 RELAPSE OF USE. 3065 02:37:01,760 --> 02:37:04,280 WHILE EMERGING EVIDENCE IS 3066 02:37:04,280 --> 02:37:06,960 SUGGESTING TREATMENT FOR AUD 3067 02:37:06,960 --> 02:37:08,400 ASSOCIATED WITH ALCOHOL LIVER 3068 02:37:08,400 --> 02:37:12,120 DISEASE STUDIES ARE NEEDED TO 3069 02:37:12,120 --> 02:37:22,640 ADDRESS THE AUD TREATMENT ON AH 3070 02:37:22,640 --> 02:37:22,880 OUTCOMES. 3071 02:37:22,880 --> 02:37:26,680 WE NEED TO BUILD COLLABORATIONS 3072 02:37:26,680 --> 02:37:27,680 BETWEEN PHARMACOLOGISTS AND 3073 02:37:27,680 --> 02:37:34,480 ADDICTION MEDICINE SPECIALISTS. 3074 02:37:34,480 --> 02:37:36,520 STUDIES ARE NEEDED TO LOOK AT 3075 02:37:36,520 --> 02:37:38,080 TOXICITY FOR MEDICATION FOR AUD 3076 02:37:38,080 --> 02:37:41,160 WITH AH PATIENTS. 3077 02:37:41,160 --> 02:37:46,640 IN THE NEXT FIVE YEARS, WE'LL 3078 02:37:46,640 --> 02:37:48,480 HAVE CLINICAL TRIALS ON THE 3079 02:37:48,480 --> 02:37:51,640 INTERVENTIONS AND TREATMENTS FOR 3080 02:37:51,640 --> 02:37:53,800 AUD AND AH. 3081 02:37:53,800 --> 02:37:56,000 IT WILL ALSO USE A MORE 3082 02:37:56,000 --> 02:38:00,800 ADAPTIVE -- IT WILL USE MORE 3083 02:38:00,800 --> 02:38:03,680 ADAPTIVE TRIAL DESIGN AND 3084 02:38:03,680 --> 02:38:09,760 DECENTRALIZE THE TRIAL MEASURES. 3085 02:38:09,760 --> 02:38:11,520 WE KNOW AS THE CREATED HIGH 3086 02:38:11,520 --> 02:38:14,760 QUALITY DATA AND THAT'S WHAT WE 3087 02:38:14,760 --> 02:38:18,800 WANT TO MAKE THE DATA MORE 3088 02:38:18,800 --> 02:38:19,640 ACCESSIBLE TO RESEARCHERS 3089 02:38:19,640 --> 02:38:27,640 INCLUDING TO RESEARCHERS FROM 3090 02:38:27,640 --> 02:38:38,160 OUTSIDE ALCHEPNET AND PLAN TO 3091 02:38:44,040 --> 02:38:50,240 HAVE A CENTER TO MONITOR THE 3092 02:38:50,240 --> 02:38:50,880 CLINICAL TRIAL PROGRESS AND 3093 02:38:50,880 --> 02:38:53,720 PROVIDE PATIENT SUPPORT. 3094 02:38:53,720 --> 02:38:58,280 THIS CONCLUDES OUR PRESENTATION 3095 02:38:58,280 --> 02:38:59,680 ON ALCHEPNET AND NOW WELCOME 3096 02:38:59,680 --> 02:39:00,320 QUESTIONS AND COMMENTS FROM THE 3097 02:39:00,320 --> 02:39:01,320 COUNCIL. 3098 02:39:01,320 --> 02:39:02,680 >>THANK YOU, PETER. 3099 02:39:02,680 --> 02:39:04,600 THAT WAS AN EXCELLENT 3100 02:39:04,600 --> 02:39:05,400 EXPLANATION OF WHERE YOU'VE BEEN 3101 02:39:05,400 --> 02:39:14,840 AND WHERE YOU WANT TO BE. 3102 02:39:14,840 --> 02:39:16,280 WE ALREADY HAVE QUESTIONS 3103 02:39:16,280 --> 02:39:17,800 RAISED. 3104 02:39:17,800 --> 02:39:18,160 LAURA NAGY. 3105 02:39:18,160 --> 02:39:20,560 >>I'M PLEASED YOU'RE ALL 3106 02:39:20,560 --> 02:39:22,440 WORKING TO EXTENT THE ALCHEPNET. 3107 02:39:22,440 --> 02:39:24,720 THE WORK DONE IN THE LAST TWO 3108 02:39:24,720 --> 02:39:26,000 ROUNDS HAS BEEN OUTSTANDING. 3109 02:39:26,000 --> 02:39:27,640 I HAVE A FEW QUESTIONS ABOUT 3110 02:39:27,640 --> 02:39:28,400 MOVING FORWARD. 3111 02:39:28,400 --> 02:39:33,320 PETER, I THINK YOU MENTIONED 3112 02:39:33,320 --> 02:39:34,960 THAT THERE'S DATA -- THE 3113 02:39:34,960 --> 02:39:38,680 QUESTION GOES TO WHETHER IT'S 3114 02:39:38,680 --> 02:39:40,640 JUST MEDICATION TREATMENT OR 3115 02:39:40,640 --> 02:39:42,200 WHETHER COGNITIVE BEHAVIORAL 3116 02:39:42,200 --> 02:39:47,400 THERAPIES WOULD BE ALSO PART OF 3117 02:39:47,400 --> 02:39:50,680 THE ONGOING TRIALS BECAUSE YOU 3118 02:39:50,680 --> 02:39:52,160 MENTIONED MORE MEDICATIONS THAN 3119 02:39:52,160 --> 02:39:52,920 BEHAVIORAL THERAPIES. 3120 02:39:52,920 --> 02:39:56,160 >>THANK YOU FOR YOUR QUESTION. 3121 02:39:56,160 --> 02:39:59,200 FOR FUTURE DIRECTION I THINK THE 3122 02:39:59,200 --> 02:40:02,520 INTERVENTION ARE TREATMENT FOR 3123 02:40:02,520 --> 02:40:03,640 AUD WILL INCLUDE BOTH 3124 02:40:03,640 --> 02:40:06,400 PHARMACEUTICAL AND 3125 02:40:06,400 --> 02:40:09,440 NON-PHARMACEUTICAL APPROACHES 3126 02:40:09,440 --> 02:40:10,080 INCLUDING THERAPIES. 3127 02:40:10,080 --> 02:40:12,680 >>AND MY SECOND QUESTION HAS TO 3128 02:40:12,680 --> 02:40:15,680 DO WITHIN THE PAST THE NIAAA 3129 02:40:15,680 --> 02:40:17,000 FUNDED TRANSLATIONAL STUDIES IN 3130 02:40:17,000 --> 02:40:17,760 PARALLEL WITH THE CLINICAL 3131 02:40:17,760 --> 02:40:20,640 TRIALS AND I THINK THAT IS REEL 3132 02:40:20,640 --> 02:40:22,320 HAS MOVED THE FIELD FORWARD IN 3133 02:40:22,320 --> 02:40:24,760 TERMS OF BIO MARKERS AND 3134 02:40:24,760 --> 02:40:25,360 MECHANISMS. 3135 02:40:25,360 --> 02:40:28,200 I'M WONDERING IF TRANSLATIONAL 3136 02:40:28,200 --> 02:40:31,200 STUDIES ARE PART OF THIS CONCEPT 3137 02:40:31,200 --> 02:40:34,360 CLEARANCE. 3138 02:40:34,360 --> 02:40:39,520 >>FIRST OF ALL, NOTHING HAS 3139 02:40:39,520 --> 02:40:42,960 BEEN DECIDED YET FOR THE NEXT 3140 02:40:42,960 --> 02:40:45,000 FIVE YEARS BUT AS MENTIONED IN 3141 02:40:45,000 --> 02:40:47,040 THE PREPARATION THE RESEARCH 3142 02:40:47,040 --> 02:40:51,680 DIRECTION HAS SHIFTED TOWARDS 3143 02:40:51,680 --> 02:40:54,520 CLINICAL RESEARCH. 3144 02:40:54,520 --> 02:40:59,960 THE PREVIOUS UL 1s MAY SUNSET IN 3145 02:40:59,960 --> 02:41:09,600 THE FUTURE THE RESEARCHERS HAVE 3146 02:41:09,600 --> 02:41:12,880 ALTERNATIVE FUNDING MECHANISM TO 3147 02:41:12,880 --> 02:41:14,600 COLLABORATE TO USE THE DATA AND 3148 02:41:14,600 --> 02:41:16,320 USE THE BIO SAMPLES. 3149 02:41:16,320 --> 02:41:21,760 >>THANK YOU. 3150 02:41:21,760 --> 02:41:23,680 >>I'LL MENTION, LAURA THAT I 3151 02:41:23,680 --> 02:41:26,360 THINK THIS IS ALSO AN 3152 02:41:26,360 --> 02:41:28,480 OPPORTUNITY AND IT WILL BE 3153 02:41:28,480 --> 02:41:31,280 DISCUSSED IN THE FUTURE BUT FOR 3154 02:41:31,280 --> 02:41:32,200 BAC TRANSLATION. 3155 02:41:32,200 --> 02:41:33,960 SHOULD EVIDENCE COME FROM THE 3156 02:41:33,960 --> 02:41:35,160 CLINICAL STUDY IT COULD BE MOVED 3157 02:41:35,160 --> 02:41:37,120 BACK TO THE ANIMAL MODELS TO 3158 02:41:37,120 --> 02:41:39,320 VALIDATE SOME OF THE ANIMAL 3159 02:41:39,320 --> 02:41:39,600 MODELS. 3160 02:41:39,600 --> 02:41:40,320 IT'S SOMETHING IN THE BACK OF MY 3161 02:41:40,320 --> 02:41:42,960 MIND AT LEAST. 3162 02:41:42,960 --> 02:41:46,280 SO THE NEXT PERSON UP I THINK IS 3163 02:41:46,280 --> 02:41:53,960 CONNIE. 3164 02:41:53,960 --> 02:41:54,800 >>YOUR MUTED. 3165 02:41:54,800 --> 02:41:56,200 >>THANK YOU VERY MUCH. 3166 02:41:56,200 --> 02:41:57,560 WHAT A GREAT PRESENTATION AND 3167 02:41:57,560 --> 02:42:02,120 OVERVIEW OF THINGS. 3168 02:42:02,120 --> 02:42:04,840 THIS IS MY LAST COUNCIL MEETING 3169 02:42:04,840 --> 02:42:07,640 I'LL BE AT SO MY WORDS ARE WHAT 3170 02:42:07,640 --> 02:42:10,280 A PERFECT OPPORTUNITY THIS WHOLE 3171 02:42:10,280 --> 02:42:11,600 AREA PROVIDES FOR HEALTH 3172 02:42:11,600 --> 02:42:12,600 SERVICES RESEARCH AND FROM THE 3173 02:42:12,600 --> 02:42:14,520 PERSPECTIVE OF HOW CAN THE 3174 02:42:14,520 --> 02:42:18,040 SYSTEM BE DESIGN TO ACCOMMODATE 3175 02:42:18,040 --> 02:42:19,640 WHAT OTHER INSURANCE PLANS ARE 3176 02:42:19,640 --> 02:42:21,040 TWO SEPARATE BENEFITS. 3177 02:42:21,040 --> 02:42:23,080 MEDICAL AND BEHAVIORAL HEALTH 3178 02:42:23,080 --> 02:42:23,320 BENEFIT. 3179 02:42:23,320 --> 02:42:29,200 I JUST WANT TO MAKE A COMMENT 3180 02:42:29,200 --> 02:42:31,320 THAT THERE ARE SYNERGIES WITH 3181 02:42:31,320 --> 02:42:33,560 THIS KIND OF RESEARCH AND ALSO 3182 02:42:33,560 --> 02:42:36,400 THE SERVICES ANGLE OF HOW WE CAN 3183 02:42:36,400 --> 02:42:39,080 GET THIS INTO THE REAL WORLD OF 3184 02:42:39,080 --> 02:42:40,760 THE DELIVERY SYSTEM. 3185 02:42:40,760 --> 02:42:43,680 THOSE ARE A FINAL COMMENT AS 3186 02:42:43,680 --> 02:42:47,680 IT'S AN OPPORTUNITY. 3187 02:42:47,680 --> 02:42:58,240 >>AS THEY SAY IN FRIEND, BIEN 3188 02:43:01,080 --> 02:43:02,720 ETENDU. 3189 02:43:02,720 --> 02:43:04,320 WELL UNDERSTOOD. 3190 02:43:04,320 --> 02:43:08,800 >>WE NEED AN OFFICIAL ACTION 3191 02:43:08,800 --> 02:43:10,480 AND I WOULD APPRECIATE IF ONE OF 3192 02:43:10,480 --> 02:43:11,400 THE COUNCIL MEMBERS MAKES A 3193 02:43:11,400 --> 02:43:16,320 MOTION TO APPROVE THE CONCEPT 3194 02:43:16,320 --> 02:43:18,280 AND CONCUR OR NOT IN THE CHAT 3195 02:43:18,280 --> 02:43:19,720 THAT WILL BE HELPFUL TO CAPTURE 3196 02:43:19,720 --> 02:43:22,320 THE SENTIMENTS. 3197 02:43:22,320 --> 02:43:28,400 >>SO MOVED. 3198 02:43:31,840 --> 02:43:37,520 >>KATIE MOVED IT FOR YOU. 3199 02:43:37,520 --> 02:43:38,120 >>THANK YOU. 3200 02:43:38,120 --> 02:43:42,000 THE NEXT ITEM ON THE AGENDA IS 3201 02:43:42,000 --> 02:43:43,640 THE CONSIDERATION OF THE 3202 02:43:43,640 --> 02:43:48,000 PREVIOUS COUNCIL MEETINGS, 161st 3203 02:43:48,000 --> 02:43:49,200 COUNCIL MEETING HELD IN 3204 02:43:49,200 --> 02:43:49,480 SEPTEMBER. 3205 02:43:49,480 --> 02:43:51,880 THE MINUTES WERE POSTED IN THE 3206 02:43:51,880 --> 02:43:52,840 ELECTRONIC COUNCIL BOOK. 3207 02:43:52,840 --> 02:43:55,520 DO ANY OF THE COUNCIL MEMBERS 3208 02:43:55,520 --> 02:43:56,560 HAVE ANY COMMENTS, CORRECTIONS 3209 02:43:56,560 --> 02:44:00,080 OR REVISIONS? 3210 02:44:00,080 --> 02:44:01,680 IF NOT I'LL APPRECIATE A MOTION 3211 02:44:01,680 --> 02:44:12,120 TO ACCEPT IT AS APPROVED. 3212 02:44:35,920 --> 02:44:38,640 >>SO MOVED. 3213 02:44:38,640 --> 02:44:40,080 NOW IT'S TIME FOR COUNCIL 3214 02:44:40,080 --> 02:44:40,480 DISCUSSION. 3215 02:44:40,480 --> 02:44:42,280 >>THANK YOU FOR PARTICIPATING 3216 02:44:42,280 --> 02:44:42,840 TODAY. 3217 02:44:42,840 --> 02:44:46,160 YOU HEARD SOME REALLY EXCELLENT 3218 02:44:46,160 --> 02:44:46,520 PRESENTATIONS. 3219 02:44:46,520 --> 02:44:47,720 IT'S REWARDING TO ME BECAUSE I 3220 02:44:47,720 --> 02:44:52,960 REMEMBER WHERE WE WERE AND SEE 3221 02:44:52,960 --> 02:44:56,400 WHERE WE ARE AND IT'S NICE TO 3222 02:44:56,400 --> 02:44:57,760 SEE THE PROGRESS AND QUESTIONS 3223 02:44:57,760 --> 02:45:03,040 FROM YOU ALL FROM DATA 3224 02:45:03,040 --> 02:45:07,640 MANAGEMENT TO ANYTHING YOU CAN 3225 02:45:07,640 --> 02:45:09,200 ASK ABOUT THE BUDGET AND I CAN 3226 02:45:09,200 --> 02:45:14,160 TELL YOU WHAT I DON'T KNOW. 3227 02:45:14,160 --> 02:45:16,360 IS THERE ANYTHING FROM ANYBODY 3228 02:45:16,360 --> 02:45:18,760 OR ANYTHING WE'RE NEGLECTING OR 3229 02:45:18,760 --> 02:45:20,200 AREAS THAT CAN USE MORE 3230 02:45:20,200 --> 02:45:20,480 EMPHASIS? 3231 02:45:20,480 --> 02:45:22,480 ANY COMMENTS ABOUT HARM 3232 02:45:22,480 --> 02:45:23,320 REDUCTION? 3233 02:45:23,320 --> 02:45:26,360 I HAD A MEETING WITH BOB DUPONT 3234 02:45:26,360 --> 02:45:29,960 WHERE HE WAS TRYING TO TELL ME 3235 02:45:29,960 --> 02:45:32,560 WE WERE NEGLECT IN NOT PURSUING 3236 02:45:32,560 --> 02:45:35,680 HARM REDUCTION AND REMINDED HIM 3237 02:45:35,680 --> 02:45:37,080 IT WAS ADDRESSED 40 YEARS AGO 3238 02:45:37,080 --> 02:45:41,000 AND PULLED THE PAPERS UP TO SHOW 3239 02:45:41,000 --> 02:45:41,160 HIM. 3240 02:45:41,160 --> 02:45:43,680 BUT I ALWAYS LIKE DISCUSSIONS 3241 02:45:43,680 --> 02:45:44,640 WITH BOB. 3242 02:45:44,640 --> 02:45:46,080 HE STIMULATES ME TO THINK ABOUT 3243 02:45:46,080 --> 02:45:46,960 THINGS. 3244 02:45:46,960 --> 02:45:47,160 KATIE. 3245 02:45:47,160 --> 02:45:52,680 >>THAT WAS ONE THING I WAS 3246 02:45:52,680 --> 02:45:56,840 GOING TO RAISE I ALWAYS THOUGHT 3247 02:45:56,840 --> 02:45:58,680 NIAAA WAS A PLACE FOR HARM 3248 02:45:58,680 --> 02:46:01,200 REDUCTION AND NIDA NOT AS A 3249 02:46:01,200 --> 02:46:03,640 PLACE FOR HARM REDUCTION AND 3250 02:46:03,640 --> 02:46:05,720 THAT'S SHIFTED RECENTLY WHERE I 3251 02:46:05,720 --> 02:46:11,680 THINK NIDA IS MOVING IN THAT 3252 02:46:11,680 --> 02:46:15,960 DIRECTION OR MORE RECOGNITION OF 3253 02:46:15,960 --> 02:46:17,920 NEED FOR HARM REDUCTION AND 3254 02:46:17,920 --> 02:46:18,600 COMMUNITY-ENGAGED WORK AND 3255 02:46:18,600 --> 02:46:22,320 TRYING TO MAKE SURE OUR WORK IS 3256 02:46:22,320 --> 02:46:24,920 CENTERED IN PEOPLE'S EXPERIENCE 3257 02:46:24,920 --> 02:46:28,360 WITH SUBSTANCES. 3258 02:46:28,360 --> 02:46:30,160 I'M CURIOUS IF NIAAA HAS COME 3259 02:46:30,160 --> 02:46:33,240 TOGETHER WITH NIDA ON ANY OF 3260 02:46:33,240 --> 02:46:36,840 THOSE IDEAS OR INTERESTED IN 3261 02:46:36,840 --> 02:46:38,880 PURSUING BEING MORE EXPLICIT 3262 02:46:38,880 --> 02:46:46,320 ABOUT THE NED FOR HARM REDUCTION 3263 02:46:46,320 --> 02:46:46,600 RESEARCH. 3264 02:46:46,600 --> 02:46:55,720 >>IS RAY ON? 3265 02:46:55,720 --> 02:46:56,720 >>YES. 3266 02:46:56,720 --> 02:46:58,800 >>DO YOU WANT TO ADDRESS WHAT 3267 02:46:58,800 --> 02:47:00,200 WE'RE DOING IN TREATMENT AND 3268 02:47:00,200 --> 02:47:00,520 RECOVERY. 3269 02:47:00,520 --> 02:47:01,760 I CAN START TRYING TO GO THROUGH 3270 02:47:01,760 --> 02:47:05,320 THE LIST OF THINGS WE'RE DOING 3271 02:47:05,320 --> 02:47:06,160 IN HARM REDUCTION BUT ONE YOU 3272 02:47:06,160 --> 02:47:07,960 MIGHT MENTION IS YOUR 3273 02:47:07,960 --> 02:47:10,320 INTERACTIONS WITH THE FDA ON 3274 02:47:10,320 --> 02:47:16,560 OUTCOMES. 3275 02:47:16,560 --> 02:47:17,560 I THINK SOCIAL DETERMINATES IS 3276 02:47:17,560 --> 02:47:19,840 ONE AND THE MODELS OF CONTINUUM 3277 02:47:19,840 --> 02:47:26,080 OF CARE. 3278 02:47:26,080 --> 02:47:30,400 >>GENERALLY WHAT WE ARE 3279 02:47:30,400 --> 02:47:34,240 RECOMMENDING AND AGAIN IT'S A 3280 02:47:34,240 --> 02:47:36,560 CORE RESOURCE IS WE WOULD LIKE 3281 02:47:36,560 --> 02:47:39,240 TO SEE IT FOLLOW THE ONE OR TWO 3282 02:47:39,240 --> 02:47:46,120 DRINKS A DAY BUT IN MANY CASES 3283 02:47:46,120 --> 02:47:49,080 PEOPLE CAN'T DO THAT SO WE FOUND 3284 02:47:49,080 --> 02:47:52,960 IF WE CAN JUST GET THEM REDUCE 3285 02:47:52,960 --> 02:47:54,560 THEIR DRINKING IT THE IMPROVE 3286 02:47:54,560 --> 02:47:56,280 HOW THEY FEEL AND FUNCTION AND 3287 02:47:56,280 --> 02:47:57,760 SOMETHING WE'RE TRYING TO GET 3288 02:47:57,760 --> 02:48:02,120 THROUGH THE FDA FOR MEDICATION 3289 02:48:02,120 --> 02:48:03,720 DEVELOPMENT TRIALS AS A PRIMARY 3290 02:48:03,720 --> 02:48:13,320 END POINT FOR THE FDA. 3291 02:48:13,320 --> 02:48:15,360 ACTUAL KATIE'S BEEN INVOLVED IN 3292 02:48:15,360 --> 02:48:16,400 ANALYSIS AND WE'VE DONE SEVERAL 3293 02:48:16,400 --> 02:48:20,760 DATA SETS WITH THAT AND HAVE 3294 02:48:20,760 --> 02:48:25,080 COMBINED AND TWO TRIALS ON 3295 02:48:25,080 --> 02:48:30,000 GABAPENTIN AND THERE'S STUDIES 3296 02:48:30,000 --> 02:48:31,440 THAT SHOW IF YOU DO REDUCE YOUR 3297 02:48:31,440 --> 02:48:34,400 DRINKING YOU CAN IMPROVE THE WAY 3298 02:48:34,400 --> 02:48:44,760 YOU FEEL AND FUNCTION. 3299 02:48:46,800 --> 02:48:47,560 SOMETIMES YOU CAN'T ALWAYS GET 3300 02:48:47,560 --> 02:48:50,440 PEOPLE TO STOP THEIR DRINKING 3301 02:48:50,440 --> 02:48:53,440 BUT JUST CUTTING BACK WOULD 3302 02:48:53,440 --> 02:48:54,200 IMPROVE THE SITUATION. 3303 02:48:54,200 --> 02:48:54,520 >>THANK YOU. 3304 02:48:54,520 --> 02:49:00,800 I APPRECIATE IT. 3305 02:49:00,800 --> 02:49:06,720 >>NOT TO BE SNARKY KATIE BUT 3306 02:49:06,720 --> 02:49:09,880 DOING 60 INTERVIEWS ON DRY 3307 02:49:09,880 --> 02:49:11,000 JANUARY FROM MY PERSPECTIVE IS 3308 02:49:11,000 --> 02:49:11,520 HARM REDUCTION. 3309 02:49:11,520 --> 02:49:13,600 I WOULD LIKE TO SAY WE'RE WAY 3310 02:49:13,600 --> 02:49:15,680 AHEAD OF NIDA IF YOU WANT TO 3311 02:49:15,680 --> 02:49:18,840 KNOW. 3312 02:49:18,840 --> 02:49:20,960 >>I APPRECIATE THAT. 3313 02:49:20,960 --> 02:49:23,640 YOU DON'T HAVE TO RAISE THAT AT 3314 02:49:23,640 --> 02:49:24,040 THE NEXT MEETING. 3315 02:49:24,040 --> 02:49:31,640 THANK YOU. 3316 02:49:31,640 --> 02:49:33,440 >>I APPRECIATE YOU DOING THE 3317 02:49:33,440 --> 02:49:35,440 INTERVIEWS AND HOW NIAAA WAS 3318 02:49:35,440 --> 02:49:38,840 REPRESENTED IN THE MEDIA SO 3319 02:49:38,840 --> 02:49:40,040 STRONGLY AND SOCIETY'S STARTING 3320 02:49:40,040 --> 02:49:42,880 TO OPEN UP TO POSSIBILITIES OF 3321 02:49:42,880 --> 02:49:44,480 DRINKING REDUCTION AND MORE 3322 02:49:44,480 --> 02:49:47,680 HEALTH SERVICES AND EVEN TAKING 3323 02:49:47,680 --> 02:49:49,400 TIME OFF. 3324 02:49:49,400 --> 02:49:51,400 >>ON A SERIOUS NOTE I WANT YOU 3325 02:49:51,400 --> 02:49:54,240 TO KNOW THE WAY -- WHEN THEY 3326 02:49:54,240 --> 02:49:59,600 ASKED ME, I INTERPRET THE 3327 02:49:59,600 --> 02:50:02,000 USEFULNESS OF DRY JANUARY IN A 3328 02:50:02,000 --> 02:50:03,480 HARM REDUCTION VEIN. 3329 02:50:03,480 --> 02:50:05,240 FANCY, YOU HAD A QUESTION. 3330 02:50:05,240 --> 02:50:06,040 >>THANK YOU. 3331 02:50:06,040 --> 02:50:08,560 THIS IS KIND OF SCIENTIST ON THE 3332 02:50:08,560 --> 02:50:09,840 STREET QUESTIONS. 3333 02:50:09,840 --> 02:50:12,640 SORT OF BRINGING THE QUESTIONS 3334 02:50:12,640 --> 02:50:14,240 HERE THAT I'VE BEEN HEARING FROM 3335 02:50:14,240 --> 02:50:15,680 FOLKS AND I'M HOPING YOU CAN 3336 02:50:15,680 --> 02:50:25,960 COMMENT ON TWO. 3337 02:50:26,600 --> 02:50:27,960 ONE IS THE INFORMATION/CONCERN 3338 02:50:27,960 --> 02:50:30,320 I'M HEARING FROM PEOPLE TRYING 3339 02:50:30,320 --> 02:50:32,800 TO GET SECOND NO-COST EXTENSIONS 3340 02:50:32,800 --> 02:50:34,120 THEY'VE BEEN DIALED BACK OR 3341 02:50:34,120 --> 02:50:39,360 GOTTEN TURNED DOWN FOR THEM. 3342 02:50:39,360 --> 02:50:41,840 THE OTHER IS THE CHALLENGES 3343 02:50:41,840 --> 02:50:43,680 PEOPLE ARE HAVING WITH THE DATA 3344 02:50:43,680 --> 02:50:51,920 SHARING REQUIREMENT. 3345 02:50:51,920 --> 02:50:53,240 I SPEND A LOT OF TIME WITH 3346 02:50:53,240 --> 02:50:55,680 ASSIST AND THE PROFESSORS. 3347 02:50:55,680 --> 02:50:57,840 IT'S BEEN QUITE DIFFICULT TO 3348 02:50:57,840 --> 02:50:58,960 WORK WITH THE AVAILABLE TOOLS 3349 02:50:58,960 --> 02:51:02,600 AND UNDERSTAND THE LIMITATIONS, 3350 02:51:02,600 --> 02:51:02,880 ETCETERA. 3351 02:51:02,880 --> 02:51:05,000 I DON'T KNOW IF YOU HAVE 3352 02:51:05,000 --> 02:51:06,640 ADDITIONAL INSIGHT ABOUT EITHER 3353 02:51:06,640 --> 02:51:13,600 OF THOSE ISSUES THAT I COULD 3354 02:51:13,600 --> 02:51:21,760 BRING BACK TO FOLKS I KNOW. 3355 02:51:21,760 --> 02:51:24,040 >>PHILIPPE, DO YOU WANT TO 3356 02:51:24,040 --> 02:51:29,080 ADDRESS THE NO-COST ISSUE AND 3357 02:51:29,080 --> 02:51:31,600 PHILIPPE HAS STOOD IN FOR ABE 3358 02:51:31,600 --> 02:51:33,360 AND IF HE CAN'T ANSWER WE'LL GET 3359 02:51:33,360 --> 02:51:36,120 BACK TO YOU ON THAT. 3360 02:51:36,120 --> 02:51:36,400 PHILIPPE? 3361 02:51:36,400 --> 02:51:38,200 >>I'LL FOLLOW YOUR 3362 02:51:38,200 --> 02:51:38,960 RECOMMENDATION I'LL PROBABLY 3363 02:51:38,960 --> 02:51:40,200 NEED TO GET MORE INFORMATION 3364 02:51:40,200 --> 02:51:42,560 ABOUT THE NO-COST EXTENSION TO 3365 02:51:42,560 --> 02:51:45,000 GIVE AN EDUCATED ANSWER. 3366 02:51:45,000 --> 02:51:47,400 IF YOU HAVE ANY SPECIFIC 3367 02:51:47,400 --> 02:51:51,280 QUESTION ABOUT IT, I'LL GET BACK 3368 02:51:51,280 --> 02:51:51,880 TO YOU AND GIVE AN APPROPRIATE 3369 02:51:51,880 --> 02:51:56,920 ANSWER. 3370 02:51:56,920 --> 02:52:03,560 >>AND TO ADD DETAIL, RUMORS ARE 3371 02:52:03,560 --> 02:52:07,640 THAT SECOND NO-COST EXTENSIONS 3372 02:52:07,640 --> 02:52:14,560 ARE VERY RESTRICTIVE BACK TO 3373 02:52:14,560 --> 02:52:17,080 SHORT PERIOD OF TIME AND SAYING 3374 02:52:17,080 --> 02:52:17,840 YOU'RE WORK WAS DELAYS BECAUSE 3375 02:52:17,840 --> 02:52:20,440 OF COVID IS NOT A GOOD REASON. 3376 02:52:20,440 --> 02:52:21,560 I'VE HEARD THAT. 3377 02:52:21,560 --> 02:52:22,760 I COULDN'T KNOW IF THAT'S 3378 02:52:22,760 --> 02:52:23,680 ACCURATE OR NOT. 3379 02:52:23,680 --> 02:52:27,000 THAT'S WHAT I HEARD AND I THINK 3380 02:52:27,000 --> 02:52:28,680 THAT'S PROBLEMATIC. 3381 02:52:28,680 --> 02:52:30,240 WE ALL KNOW COVID STILL 3382 02:52:30,240 --> 02:52:31,680 HAPPENING AND HAS A LONG TAIL 3383 02:52:31,680 --> 02:52:32,880 AND EVERYTHING'S DELAYED TWO 3384 02:52:32,880 --> 02:52:36,240 YEARS AGO IS NOW TRYING TO 3385 02:52:36,240 --> 02:52:39,920 HAPPEN NOW AND I THINK THERE'S A 3386 02:52:39,920 --> 02:52:43,120 RULE ABOUT COVID IS AN EXCUSE 3387 02:52:43,120 --> 02:52:44,800 FOR NOT HAVING RUN YOUR TRIAL OR 3388 02:52:44,800 --> 02:52:45,880 COLLECTED ALL THE DATA. 3389 02:52:45,880 --> 02:52:48,720 THAT'S GOING TO BE CHALLENGING 3390 02:52:48,720 --> 02:52:49,880 FOR PEOPLE. 3391 02:52:49,880 --> 02:52:55,040 >>AND CAN I ADD THE DERIVATIVE 3392 02:52:55,040 --> 02:52:56,360 DOWN STREAM EFFECT BECAUSE IF 3393 02:52:56,360 --> 02:52:57,640 YOU TALK TO ANY LARGE 3394 02:52:57,640 --> 02:52:59,400 INSTITUTION IN HEALTH CARE OR 3395 02:52:59,400 --> 02:53:00,640 RESEARCH, PEOPLE AREN'T APPLYING 3396 02:53:00,640 --> 02:53:04,080 FOR JOBS STILL. 3397 02:53:04,080 --> 02:53:09,760 THERE'S AN ENORMOUS MANPOWER 3398 02:53:09,760 --> 02:53:10,040 SHORTAGE. 3399 02:53:10,040 --> 02:53:13,800 >>IT'S HUGE AND HAS TRICKLE 3400 02:53:13,800 --> 02:53:15,600 DOWN EFFECT AND YOU CAN'T HIRE 3401 02:53:15,600 --> 02:53:18,120 PEOPLE TO HELP YOU COLLECT YOUR 3402 02:53:18,120 --> 02:53:18,400 DATA. 3403 02:53:18,400 --> 02:53:21,480 IT CAUSES REAL DELAYS THAT ARE 3404 02:53:21,480 --> 02:53:23,960 NOT DUE TO THE INVESTIGATOR 3405 02:53:23,960 --> 02:53:28,240 FAILING TO MEET THE AIMS OF THE 3406 02:53:28,240 --> 02:53:28,440 PROJECT. 3407 02:53:28,440 --> 02:53:31,040 >>WE HEAR YOU. 3408 02:53:31,040 --> 02:53:32,400 LET US LOOK INTO. 3409 02:53:32,400 --> 02:53:34,280 IT WAS NOT AWARE OF IT SO THAT'S 3410 02:53:34,280 --> 02:53:35,840 WHY WE HAVE A COUNCIL. 3411 02:53:35,840 --> 02:53:41,440 WE'LL SEE WHAT WE CAN COME UP 3412 02:53:41,440 --> 02:53:44,560 WITH AND IF WE GET AN ANSWER, 3413 02:53:44,560 --> 02:53:47,440 FELIPE WILL SEND AN E-MAIL AND 3414 02:53:47,440 --> 02:53:50,840 WE'LL LET RSA KNOW IF IT'S 3415 02:53:50,840 --> 02:53:52,080 SOMETHING WE CAN SHARE THAT WAY. 3416 02:53:52,080 --> 02:53:54,200 AND THEY'VE BEEN VERY GOOD, 3417 02:53:54,200 --> 02:53:58,840 LATELY, RSA, IN DISSEMINATING 3418 02:53:58,840 --> 02:54:03,600 INFORMATION FOR EVERYBODY. 3419 02:54:03,600 --> 02:54:07,240 ON DATA MANAGEMENT, TRISH, I 3420 02:54:07,240 --> 02:54:08,640 DON'T KNOW WHO COULD ANSWER THE 3421 02:54:08,640 --> 02:54:09,320 QUESTION ON THAT. 3422 02:54:09,320 --> 02:54:10,640 RIGHT NOW AS I UNDERSTAND IT, 3423 02:54:10,640 --> 02:54:16,360 YOU NEED TO HAVE A PLAN. 3424 02:54:16,360 --> 02:54:20,920 >>I JUST MET WITH BOTH OF OUR 3425 02:54:20,920 --> 02:54:22,040 INTEGRATIVE NEUROSCIENCE 3426 02:54:22,040 --> 02:54:23,560 INITIATIVE ON ALCOHOLISM 3427 02:54:23,560 --> 02:54:24,800 CONSORTIA IN THE LAST TWO WEEKS 3428 02:54:24,800 --> 02:54:27,600 AND THEY'RE WORKING ON CURATING 3429 02:54:27,600 --> 02:54:29,520 AND LEARNING HOW TO CURATE DATA 3430 02:54:29,520 --> 02:54:32,440 THEY USE IN COMMON HARMONIZING 3431 02:54:32,440 --> 02:54:34,200 DATA, SETTING UP REPOSITORIES. 3432 02:54:34,200 --> 02:54:42,720 IT'S KIND OF A WORK IN PROGRESS. 3433 02:54:42,720 --> 02:54:45,520 >>WE'RE CERTAINLY ON THE 3434 02:54:45,520 --> 02:54:46,720 LEARNING CURVE BUT SOME FOLKS 3435 02:54:46,720 --> 02:54:48,520 WILL TAKE THE BRUNT OF IT. 3436 02:54:48,520 --> 02:54:52,320 >>IF IT'S CLINICAL DATA, 3437 02:54:52,320 --> 02:54:53,760 CONTACT DAN FOGG. 3438 02:54:53,760 --> 02:54:56,600 NOT ONLY CAN HE BE HELPFUL BUT 3439 02:54:56,600 --> 02:54:59,200 PEOPLE CAN GET SUPPLEMENTS IF 3440 02:54:59,200 --> 02:55:01,480 THEY NEED ADDITIONAL HELP EARLY 3441 02:55:01,480 --> 02:55:04,720 ON IN GETTING THAT DATA FLOAT 3442 02:55:04,720 --> 02:55:06,160 UPLOADED IN THE SYSTEM AND THE 3443 02:55:06,160 --> 02:55:07,120 DATA ARCHIVE. 3444 02:55:07,120 --> 02:55:09,000 AS GEORGE MENTIONED FOR OTHER 3445 02:55:09,000 --> 02:55:10,960 STUDIES RIGHT NOW IT'S HAVING 3446 02:55:10,960 --> 02:55:13,360 THE PLAN AND GETTING PEOPLE TO 3447 02:55:13,360 --> 02:55:14,520 PUT A PLAN IN PLACE SO WE CAN 3448 02:55:14,520 --> 02:55:15,280 MOVE IN THAT DIRECTION. 3449 02:55:15,280 --> 02:55:19,800 >>THANK YOU. 3450 02:55:19,800 --> 02:55:22,400 >>STAY TUNED ON THE LATTER ONE 3451 02:55:22,400 --> 02:55:30,560 AS TRISH SAID. 3452 02:55:30,560 --> 02:55:32,600 I HAVE A LAB AND PUT TOGETHER A 3453 02:55:32,600 --> 02:55:33,600 PLAN FOR THE INTRAMURAL 3454 02:55:33,600 --> 02:55:33,840 RESEARCH. 3455 02:55:33,840 --> 02:55:37,920 I'M WORKING BOTH ENDS. 3456 02:55:37,920 --> 02:55:40,440 >>AS DID I FOR A FEBRUARY 3457 02:55:40,440 --> 02:55:43,680 SUBMISSION AND TALKING TO PEOPLE 3458 02:55:43,680 --> 02:55:44,720 WITH BEHAVIORAL DATA THAT'S KIND 3459 02:55:44,720 --> 02:55:48,480 OF COMPLEX OR MAYBE NOT 3460 02:55:48,480 --> 02:55:53,960 APPROPRIATE FOR SHARING. 3461 02:55:53,960 --> 02:55:55,120 I'M WORRIED ABOUT 3462 02:55:55,120 --> 02:55:56,480 RE-IDENTIFICATION AND A WENT TO 3463 02:55:56,480 --> 02:55:58,440 A WHOLE WEEKEND ON PRIVACY AND 3464 02:55:58,440 --> 02:56:00,040 RE-IDENTIFICATION OF DATA. 3465 02:56:00,040 --> 02:56:02,120 IT'S REALLY GRIM HOW QUICKLY 3466 02:56:02,120 --> 02:56:04,040 DATA CAN BE RE-IDENTIFIED AND 3467 02:56:04,040 --> 02:56:07,640 I'M NOT AN EXPERT ON THIS, I 3468 02:56:07,640 --> 02:56:17,960 JUST WENT, OH, NO. 3469 02:56:20,480 --> 02:56:30,960 >>WHY DON'T YOU CONTACT DAN. 3470 02:56:34,360 --> 02:56:38,080 >>I'D LIKE TO MAKE AN ELABORATE 3471 02:56:38,080 --> 02:56:39,240 COMMENT ABOUT THIS. 3472 02:56:39,240 --> 02:56:41,800 I SPOKE WITH THEM ABOUT 45 3473 02:56:41,800 --> 02:56:45,240 MINUTES AND APPRECIATED IT. 3474 02:56:45,240 --> 02:56:47,640 GREAT GUY AND VERY PATIENT AND 3475 02:56:47,640 --> 02:56:49,920 LISTENED TO A LOT OF GRIPINGS 3476 02:56:49,920 --> 02:56:51,680 FROM ME AS WE ARE TRYING TO 3477 02:56:51,680 --> 02:56:53,720 SQUASH OUR DATA INTO THIS. 3478 02:56:53,720 --> 02:56:55,960 I WAS GOING SIT ON MY HANDS AND 3479 02:56:55,960 --> 02:56:57,840 NOT COMMENT NOW BECAUSE I DON'T 3480 02:56:57,840 --> 02:57:01,840 LIKE DISCUSSIONS ON ZOOM. 3481 02:57:01,840 --> 02:57:05,840 WHAT I WOULD APPRECIATE PERHAPS 3482 02:57:05,840 --> 02:57:07,720 IF THERE'S ROOM FOR IT AN 3483 02:57:07,720 --> 02:57:11,120 IN-PERSON COUNCIL TO HAVE A MORE 3484 02:57:11,120 --> 02:57:13,040 IN-DEPTH CONVERSATION ABOUT THIS 3485 02:57:13,040 --> 02:57:18,280 BECAUSE WHILE I THINK IT'S A 3486 02:57:18,280 --> 02:57:19,440 GREAT IDEA ABSTRACT. 3487 02:57:19,440 --> 02:57:23,080 THERE'S ENORMOUS AMOUNT OF 3488 02:57:23,080 --> 02:57:27,400 COMPLICATIONS AND ALREADY ERRORS 3489 02:57:27,400 --> 02:57:28,680 IN THE DATABASE AND I DON'T 3490 02:57:28,680 --> 02:57:30,880 THINK THE DATA WILL PROVE TO BE 3491 02:57:30,880 --> 02:57:32,880 AS USEFUL AS MANY MANY PEOPLE 3492 02:57:32,880 --> 02:57:34,320 IMAGINE THEM TO BE BECAUSE OF 3493 02:57:34,320 --> 02:57:39,640 THE DIFFERENT WAYS THEY'RE 3494 02:57:39,640 --> 02:57:44,360 ENTERED IT'S REALLY COMPLEX AND 3495 02:57:44,360 --> 02:57:47,400 NOT EASY TO COMPLY WITH. 3496 02:57:47,400 --> 02:57:50,160 I'LL ASK IF WE CAN HAVE A GOOD 3497 02:57:50,160 --> 02:57:51,120 IN-PERSON CONVERSATION PERHAPS 3498 02:57:51,120 --> 02:57:52,440 IN MAY IF IT SUITS THE AGENDA OF 3499 02:57:52,440 --> 02:58:02,520 NIAAA. 3500 02:58:04,320 --> 02:58:06,440 >>I DON'T SEE WHY NOT. 3501 02:58:06,440 --> 02:58:08,360 WE HAVE TWO DAYS IN MAY AND WILL 3502 02:58:08,360 --> 02:58:10,560 HAVE OUR OWN COUNCIL LIKE WE'RE 3503 02:58:10,560 --> 02:58:21,040 DOING AND THE CRAN MEETING. 3504 02:58:22,400 --> 02:58:23,600 DULY NO 3505 02:58:27,240 --> 02:58:28,400 CALL 3506 02:58:43,680 --> 02:58:43,960 DU 3507 02:58:43,960 --> 02:58:44,680 DU 3508 02:58:44,680 --> 02:58:45,320 DUALLY NOTED. 3509 02:58:45,320 --> 02:58:46,960 WE CAN HAVE A WORKSHOP AND ALL 3510 02:58:46,960 --> 02:58:47,720 KINDS OF THINGS. 3511 02:58:47,720 --> 02:58:50,400 I THINK IT'S GOING TO BE A 3512 02:58:50,400 --> 02:58:50,640 CHALLENGE. 3513 02:58:50,640 --> 02:58:53,080 KNOW THAT EVERYBODY'S IN THE 3514 02:58:53,080 --> 02:58:55,160 SAME BOAT AND THERE'S A GOOD BIT 3515 02:58:55,160 --> 02:59:05,680 OF ANGST OUT THERE ABOUT IT I 3516 02:59:11,080 --> 02:59:14,000 DON'T THINK ANYBODY'S IN ANY 3517 02:59:14,000 --> 02:59:15,840 WORSE SHAPE IN THIS REGARD. 3518 02:59:15,840 --> 02:59:19,040 IN MY OWN LAB I'M TRYING TO 3519 02:59:19,040 --> 02:59:23,000 BASICALLY NOT WORRY IS WHAT I'M 3520 02:59:23,000 --> 02:59:24,400 TRYING TO SAVE TO YOU. 3521 02:59:24,400 --> 02:59:27,640 I THINK THERE'LL BE BENEFITS AND 3522 02:59:27,640 --> 02:59:30,240 DOWN SIDES WHEN THERE'S A BIG 3523 02:59:30,240 --> 02:59:30,440 SHIFT. 3524 02:59:30,440 --> 02:59:35,800 SPEAKING OF, THERE'LL BE SOME 3525 02:59:35,800 --> 02:59:39,680 SHIF 3526 02:59:39,680 --> 02:59:42,200 SHIFTS COMING DOWN WITH HOW WE 3527 02:59:42,200 --> 02:59:47,400 REVIEW GRANTS AND SIGNIFICANCE 3528 02:59:47,400 --> 02:59:51,680 AS A CRITERIA AND I'VE BEEN FOR 3529 02:59:51,680 --> 03:00:02,200 THAT FOR YEARS AND NONI BARNES 3530 03:00:03,720 --> 03:00:07,320 BEEN WORKING ON THAT AND MAYBE 3531 03:00:07,320 --> 03:00:08,240 THAT'S SOMETHING FOR A FUTURE 3532 03:00:08,240 --> 03:00:09,960 COUNCIL TO HAVE HER TALK OR HER 3533 03:00:09,960 --> 03:00:13,520 DEPUTY TO GET OUT TUNED UP AS TO 3534 03:00:13,520 --> 03:00:15,560 NOW THE NEW CRITERIA WILL WORK 3535 03:00:15,560 --> 03:00:26,160 AND WHAT THE ARE EMPHASIS ARE 3536 03:00:27,080 --> 03:00:37,240 GOING TO BE. 3537 03:00:59,960 --> 03:01:02,920 >>I THINK GETTING FEEDBACK 3538 03:01:02,920 --> 03:01:04,640 MEANS WE HAVE TO LOOK AT WHAT IT 3539 03:01:04,640 --> 03:01:07,760 REQUIRES AND MAYBE A DIVERSITY 3540 03:01:07,760 --> 03:01:10,600 WORK GROUP OR MAYBE IN-PERSONAL 3541 03:01:10,600 --> 03:01:11,640 MEETINGS BUT THOUGHT I'D ASK 3542 03:01:11,640 --> 03:01:13,160 ABOUT THE STATUS OF THAT AND 3543 03:01:13,160 --> 03:01:13,840 HIGHLIGHT THAT AS AN EXAMPLE OF 3544 03:01:13,840 --> 03:01:18,680 THE CHALLENGES. 3545 03:01:18,680 --> 03:01:22,320 >>IT'S A VERY GOOD QUESTION AND 3546 03:01:22,320 --> 03:01:23,680 WE SHOULD BRING THAT GROUP BACK 3547 03:01:23,680 --> 03:01:24,320 EVEN THE PEOPLE WHO GRADUATED 3548 03:01:24,320 --> 03:01:34,560 FROM COUNCIL. 3549 03:01:35,760 --> 03:01:37,400 TWO THINGS HAPPENED. 3550 03:01:37,400 --> 03:01:38,840 COVID AND UNIT. 3551 03:01:38,840 --> 03:01:42,120 ONE WAS BAD AND ONE WAS GOOD. 3552 03:01:42,120 --> 03:01:44,000 WE'VE DONE QUITE A LOT ABOUT 3553 03:01:44,000 --> 03:01:54,080 UNITE. 3554 03:02:01,200 --> 03:02:03,680 WE WANTED TO GET UNITE AND REAP 3555 03:02:03,680 --> 03:02:05,080 AND MAYBE YOU CAN EXPLAIN WHAT 3556 03:02:05,080 --> 03:02:07,680 REAP IS STRAIGHTENED OUT AT 3557 03:02:07,680 --> 03:02:11,200 NIAAA BEFORE WE RETURN TO OUR 3558 03:02:11,200 --> 03:02:11,640 PAROCHIAL INTERESTS. 3559 03:02:11,640 --> 03:02:14,200 I THINK YOU RAISE A GOOD POINT. 3560 03:02:14,200 --> 03:02:15,840 WE HAVE PAROCHIAL INTERESTS, LAW 3561 03:02:15,840 --> 03:02:17,520 RARKS THAT COULD BE ADDRESSED 3562 03:02:17,520 --> 03:02:18,720 AND WHERE WE COULD MOVE THINGS 3563 03:02:18,720 --> 03:02:19,640 FORWARD NOW THAT WE KNOW WHAT WE 3564 03:02:19,640 --> 03:02:27,440 KNOW. 3565 03:02:27,440 --> 03:02:29,320 BRIDGETTE. 3566 03:02:29,320 --> 03:02:30,920 >>I THINK NOW THAT THINGS ARE 3567 03:02:30,920 --> 03:02:33,280 GETTING MORE SETTLED WE'RE ABLE 3568 03:02:33,280 --> 03:02:35,120 TO FOCUS ON SOME OF THE THINGS 3569 03:02:35,120 --> 03:02:36,440 WE WERE DOING BEFORE. 3570 03:02:36,440 --> 03:02:38,600 IT'S IMPORTANT TO HAVE A 3571 03:02:38,600 --> 03:02:40,880 COORDINATED EFFORT AND NOT 3572 03:02:40,880 --> 03:02:43,080 DUPLICATE THINGS. 3573 03:02:43,080 --> 03:02:46,320 AS GEORGE MENTIONED THE RACIAL 3574 03:02:46,320 --> 03:02:47,720 ETHNIC AND EQUITY PLAN WHICH IS 3575 03:02:47,720 --> 03:02:53,440 A RECOMMENDATION FROM THE UNITE 3576 03:02:53,440 --> 03:02:57,280 COMMITTEE AND EACH NIH INSTITUTE 3577 03:02:57,280 --> 03:02:58,680 HAS ONE TO IMPROVE DIVERSITY, 3578 03:02:58,680 --> 03:03:00,840 EQUITY AND INCLUSION AT THE 3579 03:03:00,840 --> 03:03:01,160 CENTERS. 3580 03:03:01,160 --> 03:03:02,200 THAT'S SOMETHING WE'VE BEEN WORK 3581 03:03:02,200 --> 03:03:06,160 ON A LOT INTERNALLY. 3582 03:03:06,160 --> 03:03:07,840 THERE'S DIFFERENT STRATEGIES AND 3583 03:03:07,840 --> 03:03:09,440 METRICS INVOLVED AND OVER ALL 3584 03:03:09,440 --> 03:03:10,360 THERE'S BEEN SO MANY THINGS 3585 03:03:10,360 --> 03:03:12,080 GOING AND WE'RE TO THE POINT 3586 03:03:12,080 --> 03:03:15,880 WHERE WE CAN BE MORE STRATEGIC 3587 03:03:15,880 --> 03:03:16,520 IN WHAT WE'RE DOING. 3588 03:03:16,520 --> 03:03:17,800 THANKS FOR BRINGING THAT UP. 3589 03:03:17,800 --> 03:03:22,880 >>AND WE'VE BEEN SIGNING ON TO 3590 03:03:22,880 --> 03:03:25,560 EVERYTHING JOHN LORSCH AND THE 3591 03:03:25,560 --> 03:03:26,240 BRAIN INITIATIVE IS BRAVE ENOUGH 3592 03:03:26,240 --> 03:03:27,280 TO PUT OUT THERE. 3593 03:03:27,280 --> 03:03:30,840 >>CAN I REMIND PEOPLE TOO WE'LL 3594 03:03:30,840 --> 03:03:34,920 BE HIRING A CHIEF DIVERSITY 3595 03:03:34,920 --> 03:03:35,160 OFFICER. 3596 03:03:35,160 --> 03:03:36,880 PLEASE SPREAD THE WORD BROADLY 3597 03:03:36,880 --> 03:03:38,400 TO ANYONE YOU KNOW OR YOURSELVES 3598 03:03:38,400 --> 03:03:40,600 WHO MAY BE EXCELLENT IN THAT 3599 03:03:40,600 --> 03:03:40,880 POSITION. 3600 03:03:40,880 --> 03:03:43,240 THAT PERSON WHILE THEY WON'T BE 3601 03:03:43,240 --> 03:03:44,520 TASKED WITH DOING EVERYTHING WE 3602 03:03:44,520 --> 03:03:49,600 DO AROUND DIFFEVERSITY, EQUITY, 3603 03:03:49,600 --> 03:03:50,560 INCLUSION AND ACCESSIBILITY, 3604 03:03:50,560 --> 03:03:51,600 WILL BE HELPING US COORDINATE 3605 03:03:51,600 --> 03:03:54,680 THOSE EFFORTS AND THAT INCLUDES 3606 03:03:54,680 --> 03:03:55,760 BRINGING BACK OUR EXTERNAL 3607 03:03:55,760 --> 03:03:58,320 EXPERTS TO CONTINUE TO ADVISE 3608 03:03:58,320 --> 03:03:58,640 US. 3609 03:03:58,640 --> 03:04:00,080 WE GET TREMENDOUS ADVISE ABOUT 3610 03:04:00,080 --> 03:04:01,640 THE IMPORTANCE OF MENTORING FROM 3611 03:04:01,640 --> 03:04:03,000 THE FIRST MEETING. 3612 03:04:03,000 --> 03:04:04,880 WE KNOW WE LEARN A LOT. 3613 03:04:04,880 --> 03:04:07,640 IT'S JUST NA AS BRIDGET SAID 3614 03:04:07,640 --> 03:04:09,400 WE'VE BEEN BUSY WITH THE UNITE 3615 03:04:09,400 --> 03:04:11,000 ACTIVITIES AN WANT TO HIRE THE 3616 03:04:11,000 --> 03:04:14,120 COORDINATOR AND LET THAT PERSON 3617 03:04:14,120 --> 03:04:18,720 BE INVOLVED IN THE PHASES OF 3618 03:04:18,720 --> 03:04:18,920 THIS. 3619 03:04:18,920 --> 03:04:22,800 >>TO PIGGY BACK ON WHAT TRISH 3620 03:04:22,800 --> 03:04:27,640 IS SAYING, THE IDEA OF WHAT 3621 03:04:27,640 --> 03:04:29,440 MENTORSHIP IS CONTINUED TO 3622 03:04:29,440 --> 03:04:29,680 EVOLVE. 3623 03:04:29,680 --> 03:04:38,680 WE WELCOME THAT INPUT. 3624 03:04:38,680 --> 03:04:40,800 WHEN WE RECONVENE SOME WILL WANT 3625 03:04:40,800 --> 03:04:43,680 TO BE PART OF THE GROUP AND 3626 03:04:43,680 --> 03:04:46,360 WE'LL WELCOME YOUR 3627 03:04:46,360 --> 03:04:47,840 CONTRIBUTIONS. 3628 03:04:47,840 --> 03:04:51,800 WE'LL ACT ON THAT ONE AS SOON AS 3629 03:04:51,800 --> 03:04:56,880 WE CAN LAURA. 3630 03:04:56,880 --> 03:05:04,240 VICKY SAYS -- VICKY BUCKLEY PUT 3631 03:05:04,240 --> 03:05:09,560 IN HE CHAT THE DIVERSITY, 3632 03:05:09,560 --> 03:05:10,040 EQUITY, INCLUSION AND 3633 03:05:10,040 --> 03:05:10,640 ACCESSIBILITY LINK AND OTHER 3634 03:05:10,640 --> 03:05:19,280 QUESTIONS OR COMMENTS? 3635 03:05:19,280 --> 03:05:22,200 YOU GUYS ARE COMING UP WITH GOOD 3636 03:05:22,200 --> 03:05:25,160 ONES SO KEEP IT UP. 3637 03:05:25,160 --> 03:05:26,720 HAPPY TO ENTERTAIN ANY THOUGHTS. 3638 03:05:26,720 --> 03:05:28,360 WE'RE NOT OFF OUR TIME LINE FOR 3639 03:05:28,360 --> 03:05:31,400 THE END DEPENDING ON WHO HAS TO 3640 03:05:31,400 --> 03:05:33,360 GO AND WHERE THEY HAVE TO GO. 3641 03:05:33,360 --> 03:05:35,040 ANY OTHER ISSUES WE'VE 3642 03:05:35,040 --> 03:05:45,240 NEGLECTED? 3643 03:05:45,840 --> 03:05:46,520 >>ALL RIGHT. 3644 03:05:46,520 --> 03:05:48,800 NOW WE'LL INTRODUCE THE RETIRING 3645 03:05:48,800 --> 03:05:51,160 MEMBERS AND LET THEM SPEAK IF 3646 03:05:51,160 --> 03:05:52,520 THEY WANT TO SAY ANYTHING. 3647 03:05:52,520 --> 03:05:55,680 >>I HAVE A SPEECH FOR YOU AND 3648 03:05:55,680 --> 03:05:58,360 THEN I'D LIKE TO HEAR FROM JILL 3649 03:05:58,360 --> 03:06:02,240 AND CONNIE AND SCOTT. 3650 03:06:02,240 --> 03:06:03,760 I'D LIKE ANY THOUGHTS YOU HAVE. 3651 03:06:03,760 --> 03:06:07,640 AND THANK YOU FOR SERVING AS 3652 03:06:07,640 --> 03:06:10,360 MEMBERS OF THE NATIONAL ADVISORY 3653 03:06:10,360 --> 03:06:13,720 COUNCIL ON ALCOHOL AND 3654 03:06:13,720 --> 03:06:14,040 ALCOHOLISM. 3655 03:06:14,040 --> 03:06:15,640 THE SUCCESS OF THE INSTITUTE HAS 3656 03:06:15,640 --> 03:06:18,080 BEEN IN LARGE PART DUE TO THE 3657 03:06:18,080 --> 03:06:19,600 WILLINGNESS OF PEOPLE LIKE YOU 3658 03:06:19,600 --> 03:06:22,320 TO PARTICIPATE IN ADVISORY 3659 03:06:22,320 --> 03:06:22,840 COMMITTEES. 3660 03:06:22,840 --> 03:06:24,440 WE APPRECIATE HOW MANY HOURS YOU 3661 03:06:24,440 --> 03:06:25,400 SPENT IN PREPARATION FOR 3662 03:06:25,400 --> 03:06:33,160 MEETINGS AND OTHER ACTIVITIES. 3663 03:06:33,160 --> 03:06:35,640 SACRIFICING YOUR OWN INTERESTS 3664 03:06:35,640 --> 03:06:40,280 TO FACILITATE OPERATION. 3665 03:06:40,280 --> 03:06:43,480 I ENCOURAGE YOU TO GIVE THOUGHTS 3666 03:06:43,480 --> 03:06:45,520 AND GIVE TOMATOES OR HIGH 3667 03:06:45,520 --> 03:06:45,760 PRAISE. 3668 03:06:45,760 --> 03:06:47,240 WE LOVE HIGH PRAISE. 3669 03:06:47,240 --> 03:06:51,280 YOU CAN POINT TO US DIRECTIONS 3670 03:06:51,280 --> 03:06:53,680 MAYBE WE NEGLECTED. 3671 03:06:53,680 --> 03:06:55,680 JILL, YOU'VE BEEN WONDERFUL AND 3672 03:06:55,680 --> 03:07:00,320 EVEN DID DID IT TODAY, I WAS 3673 03:07:00,320 --> 03:07:01,000 PLEASED. 3674 03:07:01,000 --> 03:07:02,480 YOU MADE SURE WE'RE CONTINUING 3675 03:07:02,480 --> 03:07:06,200 WITH THE ANIMAL AND HUMAN AND 3676 03:07:06,200 --> 03:07:09,160 EVERYTHING IN BETWEEN WORK 3677 03:07:09,160 --> 03:07:11,680 WITHBOTH GENDERS AND SEXES. 3678 03:07:11,680 --> 03:07:13,600 I MAY ADD I'VE BEEN HARPING ON 3679 03:07:13,600 --> 03:07:16,360 THIS FOR THE REPORT WITH OUR 3680 03:07:16,360 --> 03:07:17,880 CONSORTIA BECAUSE I SEE THE 3681 03:07:17,880 --> 03:07:19,440 TENDENCY IN THE FIELD THEY GET A 3682 03:07:19,440 --> 03:07:20,400 DIFFERENCE BETWEEN MALES AND 3683 03:07:20,400 --> 03:07:22,320 FEMALES -- I DON'T KNOW IF YOU 3684 03:07:22,320 --> 03:07:25,880 PICKED UP ON THIS. 3685 03:07:25,880 --> 03:07:32,280 THEY GO BACK TO THEIR DEFAULT 3686 03:07:32,280 --> 03:07:35,040 RESEARCH AND I'LL WORK ON THE 3687 03:07:35,040 --> 03:07:36,680 MECHANISM IN THE MALES AND 3688 03:07:36,680 --> 03:07:40,760 MAKING IT CLEAR WHAT WE WANT 3689 03:07:40,760 --> 03:07:43,480 THEM TO DO IS WORK ON THE 3690 03:07:43,480 --> 03:07:44,680 MECHANISM OF THE MALES. 3691 03:07:44,680 --> 03:07:45,000 JILL. 3692 03:07:45,000 --> 03:07:45,320 >>THANK YOU. 3693 03:07:45,320 --> 03:07:48,000 IT'S BEEN AN HONOR AND PRIVILEGE 3694 03:07:48,000 --> 03:07:51,640 TO SERVE ON THIS COUNCIL. 3695 03:07:51,640 --> 03:07:55,040 I'VE APPRECIATED BEING PART OF 3696 03:07:55,040 --> 03:07:56,760 THE NIAAA ADVISORY COUNCIL THE 3697 03:07:56,760 --> 03:08:04,280 LAST FOUR AND APPRECIATE THE 3698 03:08:04,280 --> 03:08:05,920 THOUGHT YOU GIVE TO THE PROJECTS 3699 03:08:05,920 --> 03:08:15,160 BEING FUNDED BY THE NCAAA. 3700 03:08:15,160 --> 03:08:16,760 AND MAKING SURE THE INSTITUTE IS 3701 03:08:16,760 --> 03:08:19,400 PAYING ATTENTION TO THE GRANTS 3702 03:08:19,400 --> 03:08:24,520 BEING CONDUCTED CONSIDERING BOTH 3703 03:08:24,520 --> 03:08:26,720 SELVES HAS BEEN SOMETHING YOU 3704 03:08:26,720 --> 03:08:28,840 TASKED ME WITH WHEN YOU ASKED ME 3705 03:08:28,840 --> 03:08:34,600 TO BE PART OF THE COUNCIL AND I 3706 03:08:34,600 --> 03:08:36,840 TOOK THAT ON. 3707 03:08:36,840 --> 03:08:38,120 I APPRECIATED YOUR ROLE AS 3708 03:08:38,120 --> 03:08:39,040 INSTITUTE DIRECTOR AND SOMETHING 3709 03:08:39,040 --> 03:08:40,480 YOU HAVE AS A PRIORITY. 3710 03:08:40,480 --> 03:08:44,120 I THINK YOU CAN SEE IT IN THE 3711 03:08:44,120 --> 03:08:46,960 GRANTS AND SOME OF THE CONCEPT 3712 03:08:46,960 --> 03:08:48,680 CLEARANCES THAT WE'VE APPROVED 3713 03:08:48,680 --> 03:08:50,360 OVER THE YEARS. 3714 03:08:50,360 --> 03:08:51,640 THERE HAS BEEN AN INCREASED 3715 03:08:51,640 --> 03:08:54,800 AWARENESS OF SEX AND GENDER 3716 03:08:54,800 --> 03:08:58,240 DIFFERENCES BOTH IN THE INTEREST 3717 03:08:58,240 --> 03:08:59,640 OF THE COUNCIL AND IN THE GRANTS 3718 03:08:59,640 --> 03:09:09,800 FUNDED. 3719 03:09:15,080 --> 03:09:17,400 THIS IS IN NO SMALL PART DUE TO 3720 03:09:17,400 --> 03:09:20,360 YOUR ROLE AND I CAN'T GO THROUGH 3721 03:09:20,360 --> 03:09:21,480 ALL THE GRANTS THAT ARE GOING TO 3722 03:09:21,480 --> 03:09:22,240 BE FUNDED. 3723 03:09:22,240 --> 03:09:27,400 I SERIOUSLY READ ALL OF THEM AND 3724 03:09:27,400 --> 03:09:29,840 LOOK FOR INDICATIONS THAT SEX 3725 03:09:29,840 --> 03:09:30,640 DIFFERENCE HAS NOT BEEN 3726 03:09:30,640 --> 03:09:32,040 CONSIDERED APPROPRIATELY BY THE 3727 03:09:32,040 --> 03:09:34,320 EVALUATION OF THE STUDY 3728 03:09:34,320 --> 03:09:41,160 SECTIONS. 3729 03:09:41,160 --> 03:09:44,560 I HOPE SOMEONE ELSE WILL TAKE 3730 03:09:44,560 --> 03:09:46,280 THAT ROLE, MAYBE LAURA O'DELL. 3731 03:09:46,280 --> 03:09:48,640 I PASS THE TORCH TO YOU BECAUSE 3732 03:09:48,640 --> 03:09:49,360 I THINK IT'S INCREDIBLY 3733 03:09:49,360 --> 03:09:52,160 IMPORTANT NOW THAT WE HAVE BEEN 3734 03:09:52,160 --> 03:09:54,760 PAYING ATTENTION TO SEX AND 3735 03:09:54,760 --> 03:09:59,920 GENDER DIFFERENCES IT CONTINUES. 3736 03:09:59,920 --> 03:10:10,440 S -- ONCE YOU DISABROGATE THE 3737 03:10:11,440 --> 03:10:12,760 DATA THERE'S DIFFERENCES AND AS 3738 03:10:12,760 --> 03:10:18,120 YOU START DIGGING INTO HOW THE 3739 03:10:18,120 --> 03:10:19,400 DIFFERENT DRUGS OR BRAIN OR 3740 03:10:19,400 --> 03:10:20,920 LIVER ARE WORKING IT'S IMPORTANT 3741 03:10:20,920 --> 03:10:27,640 BOTH SEXES ARE ADEQUATELY 3742 03:10:27,640 --> 03:10:34,360 STUDIED SO BOTH CAN BE HELPED. 3743 03:10:34,360 --> 03:10:38,520 AND AS A NOTE TO MAKE SURE SEX 3744 03:10:38,520 --> 03:10:40,080 IS PART OF THE REPOSITORY SO 3745 03:10:40,080 --> 03:10:42,760 PEOPLE CAN LOOK AT IT EVEN IF 3746 03:10:42,760 --> 03:10:43,640 THE PRIMARY INVESTIGATORS 3747 03:10:43,640 --> 03:10:45,440 HAVEN'T DONE SO. 3748 03:10:45,440 --> 03:10:48,200 THANK YOU. 3749 03:10:48,200 --> 03:10:51,680 I'VE ENJOYED IT AND I GUESS I'LL 3750 03:10:51,680 --> 03:10:54,000 MISS COUNCIL MEETINGS. 3751 03:10:54,000 --> 03:10:55,560 I MISSING IN PERSON. 3752 03:10:55,560 --> 03:10:59,120 I WAS HOPING THIS WOULD BE AN IN 3753 03:10:59,120 --> 03:11:00,760 PERSON MEETING. 3754 03:11:00,760 --> 03:11:03,120 >>GIVEN THE WEATHER WE PROBABLY 3755 03:11:03,120 --> 03:11:04,880 COULD HAVE GOTTEN AWAY WITH IN 3756 03:11:04,880 --> 03:11:09,520 PERSON MEETING AND THIS IS THE 3757 03:11:09,520 --> 03:11:12,200 MILDEST WEATHER SINCE I STARTED 3758 03:11:12,200 --> 03:11:12,640 NIAAA. 3759 03:11:12,640 --> 03:11:15,120 ONE YEAR WE HAD SNOWMAGEDDON. 3760 03:11:15,120 --> 03:11:17,960 WE'LL MISS YOU, JILL AND WILL 3761 03:11:17,960 --> 03:11:20,200 TRY TO PASS THAT TORCH TO LAURA 3762 03:11:20,200 --> 03:11:22,320 AND SEE IF SHE CAN PASS IT TO 3763 03:11:22,320 --> 03:11:31,840 SOMEONE ELSE WHEN SHE LEAVES. 3764 03:11:31,840 --> 03:11:33,960 I THINK YOU STIMULATED STAFF TO 3765 03:11:33,960 --> 03:11:35,640 KEEP AN EYE ON THIS SO 3766 03:11:35,640 --> 03:11:36,320 ACCOMPLISH ACCOMPLISHED. 3767 03:11:36,320 --> 03:11:36,760 CONNIE. 3768 03:11:36,760 --> 03:11:38,720 >>IT'S BEEN A TRUE HONOR FOR ME 3769 03:11:38,720 --> 03:11:39,000 AS WELL. 3770 03:11:39,000 --> 03:11:42,600 AN HONOR AND PRIVILEGE. 3771 03:11:42,600 --> 03:11:43,880 IT'S BEEN A WONDERFUL 3772 03:11:43,880 --> 03:11:45,080 PROFESSIONAL EXPERIENCE FOR ME 3773 03:11:45,080 --> 03:11:53,400 THAT I HAD NOT ANTICIPATED QUITE 3774 03:11:53,400 --> 03:11:59,520 AS MUCH. 3775 03:11:59,520 --> 03:12:02,720 I GUESS WE'RE ALL SILOED AND 3776 03:12:02,720 --> 03:12:07,960 SAYING WE NEED TO HAVE MORE OF A 3777 03:12:07,960 --> 03:12:09,880 PERMEABLE ROLE SO PEOPLE WITH 3778 03:12:09,880 --> 03:12:11,600 DIFFERENT DISCIPLINES ARE 3779 03:12:11,600 --> 03:12:12,520 TALKING TO EACH OTHER AND 3780 03:12:12,520 --> 03:12:14,120 LEARNING FROM EACH OTHER AND 3781 03:12:14,120 --> 03:12:16,520 SEEING WHERE SYNERGIES CAN 3782 03:12:16,520 --> 03:12:18,920 HAPPEN AND OVER THE FOUR YEARS 3783 03:12:18,920 --> 03:12:25,040 THAT'S HAPP PED -- HAPPENED AND 3784 03:12:25,040 --> 03:12:28,840 KNOW LIVER DOCTORS NOW MORE THAN 3785 03:12:28,840 --> 03:12:32,120 BEFORE AND I'M GRATEFUL FOR THAT 3786 03:12:32,120 --> 03:12:32,520 EXPERIENCE. 3787 03:12:32,520 --> 03:12:38,560 AND BEYOND EXPANDING MY 3788 03:12:38,560 --> 03:12:40,920 KNOWLEDGE OF ALCOHOL BEYOND WHAT 3789 03:12:40,920 --> 03:12:43,520 THE ECONOMISTS TYPE PERSON 3790 03:12:43,520 --> 03:12:49,920 DOESN'T KNOW AND I HAD A LOT TO 3791 03:12:49,920 --> 03:12:53,640 LEARN, I DO APPRECIATE THE 3792 03:12:53,640 --> 03:12:54,400 OPPORTUNITY TO HAVE FOUND AREAS 3793 03:12:54,400 --> 03:12:57,280 OF SYNERGY AND TALK MORE ABOUT 3794 03:12:57,280 --> 03:12:58,560 ISSUES RELATED TO ACCESS, COST 3795 03:12:58,560 --> 03:13:02,680 AND QUALITY OF SERVICES AND HOW 3796 03:13:02,680 --> 03:13:04,720 THAT IMPACTS ACTUALLY GETTING 3797 03:13:04,720 --> 03:13:09,040 SERVICES PAID FOR, MANAGE D 3798 03:13:09,040 --> 03:13:10,120 ORGANIZED INTO THE SYSTEM. 3799 03:13:10,120 --> 03:13:13,080 IT'S AT THE END OF TAKING THE 3800 03:13:13,080 --> 03:13:15,640 WONDERFUL BASIC SCIENCE OF 3801 03:13:15,640 --> 03:13:17,400 DISCOVERIES MADE AND THE 3802 03:13:17,400 --> 03:13:19,400 CLINICAL STUDIES AND MAKING SURE 3803 03:13:19,400 --> 03:13:21,080 IT GETS IMPLEMENTED AND MOVED IN 3804 03:13:21,080 --> 03:13:25,960 THE REAL WORLD TO MAKE A 3805 03:13:25,960 --> 03:13:27,440 DIFFERENCE. 3806 03:13:27,440 --> 03:13:28,640 I WANT TO SAY THANK YOU TO 3807 03:13:28,640 --> 03:13:30,840 GEORGE FOR LEADING THE CHARGE IN 3808 03:13:30,840 --> 03:13:33,360 THIS THE WHOLE TIME I'VE BEEN 3809 03:13:33,360 --> 03:13:37,920 HERE AND ALSO OTHER PEOPLE WHO 3810 03:13:37,920 --> 03:13:39,520 HAVE BEEN INVOLVED AND STAFF 3811 03:13:39,520 --> 03:13:42,680 WITH HEALTH SERVICES RESEARCH, 3812 03:13:42,680 --> 03:13:44,920 TRISH POWELL, YOU CERTAINLY HAVE 3813 03:13:44,920 --> 03:13:49,120 BEEN A SUPPORTER AND DR. RAY 3814 03:13:49,120 --> 03:13:52,360 LINTON AND NOW LAURA. 3815 03:13:52,360 --> 03:13:54,800 AND I'D LIKE TO RECOGNIZE 3816 03:13:54,800 --> 03:13:58,680 RETIRED PEOPLE, ABE, HOW CAN 3817 03:13:58,680 --> 03:14:02,440 SOMEBODY NOT ASK ABE ABOUT 3818 03:14:02,440 --> 03:14:03,640 HEALTH SERVICES RESEARCH AND 3819 03:14:03,640 --> 03:14:04,800 SOMEONE WHO HAS BEEN LONG 3820 03:14:04,800 --> 03:14:07,680 RETIRED BUT HERE WHEN I FIRST 3821 03:14:07,680 --> 03:14:10,440 STARTED WAS BOB HUBENER. 3822 03:14:10,440 --> 03:14:13,160 THERE'S A LEGACY OF PEOPLE THAT 3823 03:14:13,160 --> 03:14:15,440 HAVE MADE A DIFFERENCE. 3824 03:14:15,440 --> 03:14:19,360 I WANT TO THANK ALL FOR ALL 3825 03:14:19,360 --> 03:14:20,440 YOU'RE DOING AND HOPING IT WILL 3826 03:14:20,440 --> 03:14:20,880 CONTINUE. 3827 03:14:20,880 --> 03:14:23,600 I CAN SAY TODAY'S MEETING WAS -- 3828 03:14:23,600 --> 03:14:24,800 ALL THE MEETING ARE FABULOUS. 3829 03:14:24,800 --> 03:14:28,360 I LOVE COMING TO COUNCIL. 3830 03:14:28,360 --> 03:14:33,200 IT'S BEEN ONE OF THE HIGH POINTS 3831 03:14:33,200 --> 03:14:33,840 KNOWING THREE TIMES A YEAR 3832 03:14:33,840 --> 03:14:35,840 YOU'LL BE COMING HERE AND IT'S 3833 03:14:35,840 --> 03:14:37,240 AN EXAMPLE OF STELLAR 3834 03:14:37,240 --> 03:14:39,480 CONVERSATIONS THAT HAVE TAKEN 3835 03:14:39,480 --> 03:14:40,640 PLACE AND HAVE BEEN INFORMED. 3836 03:14:40,640 --> 03:14:42,160 IT'S BEEN A WONDERFUL 3837 03:14:42,160 --> 03:14:43,040 EXPERIENCE. 3838 03:14:43,040 --> 03:14:44,520 THANK YOU ALL AND THANK YOU, 3839 03:14:44,520 --> 03:14:46,480 GEORGE, FOR LEADING THE CHARGE 3840 03:14:46,480 --> 03:14:48,560 AND MAKING IT A HEALTHY 3841 03:14:48,560 --> 03:14:49,920 ENVIRONMENT FOR THAT TO HAPPEN. 3842 03:14:49,920 --> 03:14:55,360 >>THANK YOU, CONNIE. 3843 03:14:55,360 --> 03:14:58,280 WE'LL MISS YOU TOO. 3844 03:14:58,280 --> 03:15:01,560 I REALLY THINK -- I CALL IT 3845 03:15:01,560 --> 03:15:03,640 TRYING TO SCALE UP SOME THINGS 3846 03:15:03,640 --> 03:15:07,760 WE'VE BEEN DOING TO HELP PEOPLE. 3847 03:15:07,760 --> 03:15:09,480 I'VE EVEN RAISED THE IRISH WITH 3848 03:15:09,480 --> 03:15:11,640 THE HEAL INITIATIVE. 3849 03:15:11,640 --> 03:15:14,160 I KNOW MOST OF YOU PROBABLY 3850 03:15:14,160 --> 03:15:15,720 DON'T KNOW BUT I'VE BEEN SOMEHOW 3851 03:15:15,720 --> 03:15:21,440 ELECTED TO BE ON THE BOARD OF 3852 03:15:21,440 --> 03:15:22,240 THE HEAL INITIATIVE. 3853 03:15:22,240 --> 03:15:32,680 THAT'S HEALTHY END TO THE 3854 03:15:38,120 --> 03:15:38,680 ADDICTION CRISIS. 3855 03:15:38,680 --> 03:15:41,360 IF YOU KNOW ALL THE ACRONYMS 3856 03:15:41,360 --> 03:15:44,120 IT'S TIME TO RETIRE SO IT'S NOT 3857 03:15:44,120 --> 03:15:46,320 TIME FOR ME TO RETIRE THERE. 3858 03:15:46,320 --> 03:15:52,360 I THINK WE HAVE A CHALLENGE 3859 03:15:52,360 --> 03:16:00,960 THERE. 3860 03:16:00,960 --> 03:16:03,640 THE KEY WILL BE WORKING WITH 3861 03:16:03,640 --> 03:16:05,800 OTHER FEDERAL AGENCIES TO AFFECT 3862 03:16:05,800 --> 03:16:07,640 CHANGES AN THAT'S WHERE THE 3863 03:16:07,640 --> 03:16:10,360 MONEY IS WITH SAMHSA AND HRSA. 3864 03:16:10,360 --> 03:16:12,440 WE MAY BE TAPPING YOUR BRAIN 3865 03:16:12,440 --> 03:16:15,640 AGAIN, CONNIE ON SOME OF THESE 3866 03:16:15,640 --> 03:16:16,360 ISSUES. 3867 03:16:16,360 --> 03:16:17,280 THANKS AGAIN. 3868 03:16:17,280 --> 03:16:17,880 >>WOULD LOVE TO. 3869 03:16:17,880 --> 03:16:19,680 THANK YOU. 3870 03:16:19,680 --> 03:16:23,680 >>SCOTT. 3871 03:16:23,680 --> 03:16:26,040 WHAT WORDS OF WISDOM DO YOU HAVE 3872 03:16:26,040 --> 03:16:27,000 FOR US? 3873 03:16:27,000 --> 03:16:28,840 >>BEYOND WHAT CONSTANCE AND 3874 03:16:28,840 --> 03:16:30,880 JILL ALREADY MENTIONED, MY GOSH, 3875 03:16:30,880 --> 03:16:32,560 THAT WAS PERFECT. 3876 03:16:32,560 --> 03:16:35,400 AS THEY MENTIONED, I JUST WANT 3877 03:16:35,400 --> 03:16:38,760 TO ECHO MY GRATITUDE FOR BEING 3878 03:16:38,760 --> 03:16:40,360 CHOSEN TO BE PART OF THIS. 3879 03:16:40,360 --> 03:16:40,800 IT'S BEEN AN APLACING 3880 03:16:40,800 --> 03:16:42,600 EXPERIENCE. 3881 03:16:42,600 --> 03:16:44,320 -- AN AMAZING EXPERIENCE. 3882 03:16:44,320 --> 03:16:46,240 MEETING PEOPLE AND MAKING NEW 3883 03:16:46,240 --> 03:16:49,440 FRIENDS AND SEEING OLD FRIENDS, 3884 03:16:49,440 --> 03:16:57,360 I LIKE JILL, JOYAND ENJOYED THE 3885 03:16:57,360 --> 03:16:59,320 PERSON COUNCILS, IT WAS AN 3886 03:16:59,320 --> 03:17:01,040 AMAZING EXPERIENCE EARLY ON TO 3887 03:17:01,040 --> 03:17:01,640 REALLY NETWORK. 3888 03:17:01,640 --> 03:17:03,680 I STILL KEEP IN TOUCH WITH SOME 3889 03:17:03,680 --> 03:17:07,640 OF THOSE LIVER DOCS, CONNIE. 3890 03:17:07,640 --> 03:17:08,320 IT'S GREAT TO MAKE FRIENDS WITH 3891 03:17:08,320 --> 03:17:15,000 THEM. 3892 03:17:15,000 --> 03:17:18,520 I THINK ONE OF THE THINGS I 3893 03:17:18,520 --> 03:17:20,160 DIDN'T REALIZE BEFORE COMING ON 3894 03:17:20,160 --> 03:17:21,640 TO NIAAA COUNCIL IS THE BREADTH 3895 03:17:21,640 --> 03:17:22,360 OF YOUR PORTFOLIO. 3896 03:17:22,360 --> 03:17:25,800 MORE THAN OTHER CNS INSTITUTES 3897 03:17:25,800 --> 03:17:31,560 AND I'LL LEAVE IT THAT THE. 3898 03:17:31,560 --> 03:17:33,720 NIAAA'S STRENGTH IS IN 3899 03:17:33,720 --> 03:17:35,760 CONSIDERING ADDICTION AS A WHOLE 3900 03:17:35,760 --> 03:17:36,880 BODY DISEASE PARTLY BECAUSE OF 3901 03:17:36,880 --> 03:17:42,160 THE DISEASE ITSELF AND THE 3902 03:17:42,160 --> 03:17:43,920 OPENNESS TO THINK ABOUT 3903 03:17:43,920 --> 03:17:45,920 ALTERNATIVE STRATEGIES WAS 3904 03:17:45,920 --> 03:17:49,440 CERTAINLY APPARENT TO ME AS A 3905 03:17:49,440 --> 03:17:54,440 MEMBER OF THE COUNCIL HERE. 3906 03:17:54,440 --> 03:17:56,120 THE LASTING EFFECT NIAAA HAS HAD 3907 03:17:56,120 --> 03:17:59,400 ON ME IS I MOVED OVER TO THE 3908 03:17:59,400 --> 03:18:02,480 FIELD OF ALCOHOL ADDICTION 3909 03:18:02,480 --> 03:18:09,880 ACTIVELY AND I'LL BE ATTEND IN 3910 03:18:09,880 --> 03:18:11,760 SOME OF THE UPCOMING MEETINGS 3911 03:18:11,760 --> 03:18:13,520 NEXT SUMMER AND IT WILL BE GREAT 3912 03:18:13,520 --> 03:18:15,040 TO CONNECT AND SEE SOME OF YOU 3913 03:18:15,040 --> 03:18:15,560 ONCE AGAIN. 3914 03:18:15,560 --> 03:18:16,480 I'VE LEARNED SO MUCH FROM 3915 03:18:16,480 --> 03:18:17,800 EVERYBODY AND IT'S BEEN AN HONOR 3916 03:18:17,800 --> 03:18:19,600 AND PLEASURE TO EVERYBODY. 3917 03:18:19,600 --> 03:18:21,600 I'LL MISSING ON THE CALL EVERY 3918 03:18:21,600 --> 03:18:22,440 THREE MONTHS OR SO OR FOUR 3919 03:18:22,440 --> 03:18:27,040 MONTHS OR SO. 3920 03:18:27,040 --> 03:18:28,480 WITH THE POTENTIAL AGENDA I 3921 03:18:28,480 --> 03:18:31,200 HEARD FOR THE NEXT MAY MEETING 3922 03:18:31,200 --> 03:18:33,520 MAYBE I'LL ASK GEORGE IF I CAN 3923 03:18:33,520 --> 03:18:35,920 COME BACK AND COP A SQUAT DO 3924 03:18:35,920 --> 03:18:37,720 HEAR SOME OF THE DISCUSSIONS. 3925 03:18:37,720 --> 03:18:41,240 IN THE INTEREST OF TIME, IT'S 3926 03:18:41,240 --> 03:18:42,560 4:48, I'LL STOP BELABORING THIS 3927 03:18:42,560 --> 03:18:44,240 BUT AGAIN I'LL MISS YOU ALL. 3928 03:18:44,240 --> 03:18:45,960 IT'S BEEN A HOOT. 3929 03:18:45,960 --> 03:18:46,920 HOPEFULLY WE'LL CONNECT AGAIN IN 3930 03:18:46,920 --> 03:18:47,760 THE FUTURE AND THANKS AGAIN FOR 3931 03:18:47,760 --> 03:18:57,160 THE OPPORTUNITY. 3932 03:18:57,160 --> 03:18:58,640 >>WE'LL TAP ON YOU BECAUSE YOU 3933 03:18:58,640 --> 03:19:01,880 HAVE A UNIQUE CAPACITY TO TAP 3934 03:19:01,880 --> 03:19:03,400 ACROSS DISCIPLINES AND IT'S 3935 03:19:03,400 --> 03:19:05,200 SOMETHING WE VALUED IN YOUR 3936 03:19:05,200 --> 03:19:06,240 DISCUSSIONS WITH US OVER THE 3937 03:19:06,240 --> 03:19:06,840 YEARS. 3938 03:19:06,840 --> 03:19:09,040 ALL OF YOU REALLY HAVE UNIQUE 3939 03:19:09,040 --> 03:19:09,640 CONTRIBUTIONS AND HELPED US A 3940 03:19:09,640 --> 03:19:13,280 LOT. 3941 03:19:13,280 --> 03:19:15,800 I JUST WANT YOU TO REALIZE IT 3942 03:19:15,800 --> 03:19:17,440 WASN'T A ONE-WAY STREET BY ANY 3943 03:19:17,440 --> 03:19:19,640 MEANS. 3944 03:19:19,640 --> 03:19:25,200 WE HIRED YOU AS I SAID FOR A 3945 03:19:25,200 --> 03:19:26,560 REASON AND YOU LOOKED UP TO THE 3946 03:19:26,560 --> 03:19:28,000 REASONS AND GRATEFUL YOU WERE 3947 03:19:28,000 --> 03:19:29,200 WILLING TO DO THIS AND STUCK 3948 03:19:29,200 --> 03:19:32,520 WITH US AND SO FORTH. 3949 03:19:32,520 --> 03:19:35,440 ANY WAY, CONTINUE TO BE 3950 03:19:35,440 --> 03:19:36,640 AMBASSADORS EVERYBODY FOR NIAAA. 3951 03:19:36,640 --> 03:19:42,480 WE ARE THE LITTLE ENGINE THAT 3952 03:19:42,480 --> 03:19:48,640 COULD AND ALCOHOL UNHEALTHY 3953 03:19:48,640 --> 03:19:50,000 ALCOHOL USE I NOW ADOPTED THAT 3954 03:19:50,000 --> 03:19:53,600 WORD THIS WEEK, IS PERMEATING 3955 03:19:53,600 --> 03:19:54,360 OUR SOCIETY. 3956 03:19:54,360 --> 03:19:58,160 I DON'T KNOW WHETHER I CAN 3957 03:19:58,160 --> 03:20:00,160 RECAPITULATE IT BUT JOHN KELLY 3958 03:20:00,160 --> 03:20:02,520 WROTE AND WE FINALLY FOUND OUT 3959 03:20:02,520 --> 03:20:05,640 JOHN AND I COULD FIND WHERE HE 3960 03:20:05,640 --> 03:20:08,640 WROTE IT AND HE WROTE IT AND 3961 03:20:08,640 --> 03:20:11,280 COULDN'T FIND IT AND HOW ALCOHOL 3962 03:20:11,280 --> 03:20:14,680 IS BECOMING THE -- THE PATHOLOGY 3963 03:20:14,680 --> 03:20:25,200 WITH ALCOHOL IS BECOMING ENURED 3964 03:20:27,720 --> 03:20:31,040 IN OUR SOCIETY AND THE PATHOLOGY 3965 03:20:31,040 --> 03:20:32,640 DOCS WONDERED WHERE I KNEW THAT 3966 03:20:32,640 --> 03:20:39,640 WORD AND I SAID MY MOTHER WAS A 3967 03:20:39,640 --> 03:20:41,640 LINGUISTICS TEACHER. 3968 03:20:41,640 --> 03:20:45,960 I THINK WE HAVE A SPECIAL ROLE 3969 03:20:45,960 --> 03:20:47,600 IN SOCIETY AND HAVE THE LARGEST 3970 03:20:47,600 --> 03:20:51,680 FUNDER OF ALCOHOL RESEARCH IN 3971 03:20:51,680 --> 03:20:58,320 THE WORLD. 3972 03:20:58,320 --> 03:21:01,560 I THINK A LARGE PART OF THE 3973 03:21:01,560 --> 03:21:03,160 POPULATION HAS NEVER HEARD OF 3974 03:21:03,160 --> 03:21:05,760 NIH LET ALONE NIAAA. 3975 03:21:05,760 --> 03:21:07,000 CONTINUE TO BE AMBASSADORS. 3976 03:21:07,000 --> 03:21:09,120 IN YOUR WORLDS OF ACADEMIA A LOT 3977 03:21:09,120 --> 03:21:12,280 OF PEOPLE DON'T KNOW WE EXIST 3978 03:21:12,280 --> 03:21:15,240 AND THERE'S GOOD INFORMATION ON 3979 03:21:15,240 --> 03:21:17,640 OUR WEBSITE THANKS TO BRIDGET 3980 03:21:17,640 --> 03:21:20,000 AND HER TEAM AND IT IT'S BEEN 3981 03:21:20,000 --> 03:21:22,160 UPDATED AND IS TOP NOTCH FROM MY 3982 03:21:22,160 --> 03:21:22,480 PERSPECTIVE. 3983 03:21:22,480 --> 03:21:24,840 I URGE YOU ALL TO LOOK AT OUR 3984 03:21:24,840 --> 03:21:27,200 WEBSITE AND IF YOU FIND ERRORS 3985 03:21:27,200 --> 03:21:28,920 OR IN THE HPCR IF YOU FIND 3986 03:21:28,920 --> 03:21:31,160 ERRORS DOWN THE LINE, SOME 3987 03:21:31,160 --> 03:21:34,040 THINGS MAY GO OUT OF DATE, 3988 03:21:34,040 --> 03:21:34,560 PLEASE LET US KNOW. 3989 03:21:34,560 --> 03:21:38,600 THEY'RE ALL LIVING DOCUMENTS. 3990 03:21:38,600 --> 03:21:42,200 THEY CAN BE EDITED AND FIXED. 3991 03:21:42,200 --> 03:21:43,320 SO DOES ANYBODY ELSE HAVE 3992 03:21:43,320 --> 03:21:50,880 COMMENTS OR THOUGHTS OR 3993 03:21:50,880 --> 03:21:51,160 QUESTIONS? 3994 03:21:51,160 --> 03:21:51,320 RV? 3995 03:21:51,320 --> 03:21:53,040 >>I NEED TO MAKE AN 3996 03:21:53,040 --> 03:21:54,680 ANNOUNCEMENT OF THE NEXT MEETING 3997 03:21:54,680 --> 03:21:55,040 DATES. 3998 03:21:55,040 --> 03:21:56,280 IT WILL BE MAY 9. 3999 03:21:56,280 --> 03:21:58,720 THAT WILL BE FOLLOWED BY THE 4000 03:21:58,720 --> 03:22:01,240 MEETING ON MAY 10. 4001 03:22:01,240 --> 03:22:03,720 AND AS GEORGE MENTIONED WE'RE 4002 03:22:03,720 --> 03:22:06,280 PLANNING TO DO IT AS A HYBRID 4003 03:22:06,280 --> 03:22:07,280 MEETING AND HOPEFULLY MANY WILL 4004 03:22:07,280 --> 03:22:08,240 HAVE A CHANCE TO COME AND VISIT 4005 03:22:08,240 --> 03:22:11,320 US IN PERSON. 4006 03:22:11,320 --> 03:22:17,200 >>I INTEND TO BE THERE IN 4007 03:22:17,200 --> 03:22:20,600 PERSON AND I HOPE YOU ALL CAN 4008 03:22:20,600 --> 03:22:23,960 COME AND IT'S A BEAUTIFUL TIME 4009 03:22:23,960 --> 03:22:26,160 IN WASHINGTON. 4010 03:22:26,160 --> 03:22:29,160 USUALLY THE WEATHER IS GOOD SO 4011 03:22:29,160 --> 03:22:31,920 COME ON DOWN OR COME ON OUT OR 4012 03:22:31,920 --> 03:22:33,480 COME ON UP WHEREVER YOU ARE. 4013 03:22:33,480 --> 03:22:34,400 ALL RIGHT. 4014 03:22:34,400 --> 03:22:37,400 I'M GOING TO SIGN OFF. 4015 03:22:37,400 --> 03:22:39,440 TRISH, DO YOU WANT TO SAY FINAL 4016 03:22:39,440 --> 03:22:39,640 WORDS? 4017 03:22:39,640 --> 03:22:40,720 >>I WANT TO THANK EVERYBODY. 4018 03:22:40,720 --> 03:22:42,280 THE PRESENTATIONS WERE FANTASTIC 4019 03:22:42,280 --> 03:22:45,000 AND THE DISCUSSIONS WERE GREAT. 4020 03:22:45,000 --> 03:22:46,960 WE ALWAYS APPRECIATE THE INSIGHT 4021 03:22:46,960 --> 03:22:48,680 EVEN THOSE LEAVING US, PLEASE 4022 03:22:48,680 --> 03:22:50,120 CONTINUE TO GIVE US INSIGHT. 4023 03:22:50,120 --> 03:22:51,960 JUST BECAUSE YOU'RE NOT ON 4024 03:22:51,960 --> 03:22:55,800 COUNCIL, YOU CAN HELP US IN A 4025 03:22:55,800 --> 03:22:57,600 LOT OF DIFFERENT WAYS. 4026 03:22:57,600 --> 03:22:59,120 ONCE ON COUNCILS WE ALWAYS HAVE 4027 03:22:59,120 --> 03:22:59,840 YOUR E-MAILS. 4028 03:22:59,840 --> 03:23:02,360 >>AND VICKY AS EXECUTIVE 4029 03:23:02,360 --> 03:23:05,320 OFFICER, ANYTHING YOU WANT TO 4030 03:23:05,320 --> 03:23:08,440 SAY ABOUT THE STATE OF THE 4031 03:23:08,440 --> 03:23:09,200 INSTITUTE AND THE HIRING WE'RE 4032 03:23:09,200 --> 03:23:11,160 DOING OR TRYING? 4033 03:23:11,160 --> 03:23:12,840 >>NO, I THINK YOU COVERED 4034 03:23:12,840 --> 03:23:13,520 EVERYTHING, GEORGE. 4035 03:23:13,520 --> 03:23:15,680 IT WAS GREAT TO SEE EVERYONE 4036 03:23:15,680 --> 03:23:22,520 TODAY AND I AGREE WITH TREASISH 4037 03:23:22,520 --> 03:23:23,000 GREAT PRESENTATIONS AND 4038 03:23:23,000 --> 03:23:23,320 DISCUSSIONS. 4039 03:23:23,320 --> 03:23:23,920 >>WE'RE ALSO LOOKING FOR A 4040 03:23:23,920 --> 03:23:26,800 PROGRAM OFFICER. 4041 03:23:26,800 --> 03:23:27,800 YOU'RE NOT THE ONLY PEOPLE 4042 03:23:27,800 --> 03:23:28,840 LOOKING FOR PEOPLE TO DO THE 4043 03:23:28,840 --> 03:23:29,040 WORK. 4044 03:23:29,040 --> 03:23:32,360 WE ARE TOO. 4045 03:23:32,360 --> 03:23:34,160 AND THEN BRIDGET, DO YOU HAVE 4046 03:23:34,160 --> 03:23:36,040 ANYTHING YOU WANT TO SAY, 4047 03:23:36,040 --> 03:23:36,880 SCIENCE POLICY, PRESS OFFICE? 4048 03:23:36,880 --> 03:23:39,200 ANYTHING YOU WANT TO CONVEY TO 4049 03:23:39,200 --> 03:23:41,000 EVERYBODY BEFORE WE SIGN OFF? 4050 03:23:41,000 --> 03:23:42,800 >>NO, WE THANK YOU ALL. 4051 03:23:42,800 --> 03:23:45,000 GOOD TO SEE YOU AND AS GEORGE 4052 03:23:45,000 --> 03:23:45,960 MENTIONED IF YOU FIND ANYTHING 4053 03:23:45,960 --> 03:23:48,920 ON OUR WEBSITE, FEEL FREE TO LET 4054 03:23:48,920 --> 03:23:50,080 US KNOW. 4055 03:23:50,080 --> 03:23:53,320 WE'RE OPEN TO ALL YOUR INPUT. 4056 03:23:53,320 --> 03:23:53,840 THANKS. 4057 03:23:53,840 --> 03:23:55,680 >>AS THEY USED TO SAY IN THE 4058 03:23:55,680 --> 03:24:02,280 BRITISH NEWS IT'S TIME TO SAY 4059 03:24:02,280 --> 00:00:00,000 GOOD NIGHT SO GOOD NIGHT.