1 00:00:19,168 --> 00:00:22,371 >> WELCOME TO THE 153RD MEETING 2 00:00:22,371 --> 00:00:23,773 OF THE NATIONAL ADVISORY COUNCIL 3 00:00:23,773 --> 00:00:24,307 ON AGING. 4 00:00:24,307 --> 00:00:25,508 SO WE'RE GOING TO START OFF JUST 5 00:00:25,508 --> 00:00:29,779 WITH A ROLL CALL OF OUR 6 00:00:29,779 --> 00:00:30,213 COUNCILMEMBERS. 7 00:00:30,213 --> 00:00:32,315 IF YOU COULD PLEASE GIVE YOUR 8 00:00:32,315 --> 00:00:35,585 NAME, YOUR INSTITUTION AND YOUR 9 00:00:35,585 --> 00:00:43,726 TITLE AS I CALL YOUR NAME OUT. 10 00:00:43,726 --> 00:00:47,563 OUT. 11 00:00:47,563 --> 00:00:52,368 >> DR. SANJAY ASTHANA, PROFESSOR 12 00:00:52,368 --> 00:00:54,737 AND ASSOCIATE DEAN, UNIVERSITY 13 00:00:54,737 --> 00:00:55,805 OF WISCONSIN SCHOOL OF MEDICINE. 14 00:00:55,805 --> 00:00:58,941 >> I'M ANNE CASE, PROFESSOR OF 15 00:00:58,941 --> 00:01:00,910 ECONOMICS AND PUBLIC AFFAIRS 16 00:01:00,910 --> 00:01:01,777 EMERITUS AT PRINCETON 17 00:01:01,777 --> 00:01:05,615 UNIVERSITY. 18 00:01:05,615 --> 00:01:10,186 >> DR. SI CILIBERTO, I THINK SHS 19 00:01:10,186 --> 00:01:15,891 NOT ON THIS MORNING YET. 20 00:01:15,891 --> 00:01:16,259 DR. GREENSPAN. 21 00:01:16,259 --> 00:01:18,594 >> HI, I'M DR. SUSAN GREENSPAN, 22 00:01:18,594 --> 00:01:19,996 PROFESSOR OF MEDICINE AT 23 00:01:19,996 --> 00:01:21,697 UNIVERSITY OF PITTSBURGH. 24 00:01:21,697 --> 00:01:23,499 >> DR. HUANG? 25 00:01:23,499 --> 00:01:30,439 >> YES, YADONG HUANG, GLADSTONE 26 00:01:30,439 --> 00:01:33,576 INSTITUTE AND PROFESSOR AT UCSF. 27 00:01:33,576 --> 00:01:35,011 >> DR. HULING-HUMMEL? 28 00:01:35,011 --> 00:01:38,614 >> HELLO, DR. REVEREND CYNTHIA 29 00:01:38,614 --> 00:01:39,282 HULING-HUMMEL FROM NEW YORK. 30 00:01:39,282 --> 00:01:41,350 I AM A MEMBER OF THE ALZHEIMER'S 31 00:01:41,350 --> 00:01:45,288 CLINICAL TRIALS CON OR S CONSORI 32 00:01:45,288 --> 00:01:47,490 HAVE BEEN PARTICIPATING IN THE 33 00:01:47,490 --> 00:01:48,391 STUDY FOR 15 YEARS. 34 00:01:48,391 --> 00:01:50,526 >> DR. INOUYE. 35 00:01:50,526 --> 00:01:51,961 >> HI, EVERYONE. 36 00:01:51,961 --> 00:01:53,596 I'M SHARON INOUYE, PROFESSOR OF 37 00:01:53,596 --> 00:01:55,264 MEDICINE AT HARVARD MEDICAL 38 00:01:55,264 --> 00:01:56,565 SCHOOL, DIRECTOR OF THE AGING 39 00:01:56,565 --> 00:01:58,100 BRAIN CENTER AT HEBREW SENIOR 40 00:01:58,100 --> 00:02:00,636 LIFE AND EDITOR-IN-CHIEF OF JAMA 41 00:02:00,636 --> 00:02:01,537 INTERNAL MEDICINE. 42 00:02:01,537 --> 00:02:04,006 THANK YOU. 43 00:02:04,006 --> 00:02:06,909 >> DR. KHAN. 44 00:02:06,909 --> 00:02:11,180 >> I'M DR. SOHAIL KHAN, I'M THE 45 00:02:11,180 --> 00:02:13,316 DIRECTOR OF HEALTH RESEARCH AT 46 00:02:13,316 --> 00:02:17,019 CHEROKEE NATION AND CHAIR OF THE 47 00:02:17,019 --> 00:02:18,120 CHEROKEE NATION. 48 00:02:18,120 --> 00:02:20,056 >> DR. LONGO? 49 00:02:20,056 --> 00:02:22,158 >> HELLO, I'M FRANK LONGO. 50 00:02:22,158 --> 00:02:24,460 I'M A PROFESSOR OF NEUROLOGY AND 51 00:02:24,460 --> 00:02:25,728 NEUROLOGICAL SCIENCES AT 52 00:02:25,728 --> 00:02:29,065 STANFORD UNIVERSITY. 53 00:02:29,065 --> 00:02:29,465 >> DR. LUNDEBJERG. 54 00:02:29,465 --> 00:02:31,133 >> HI, I'M NANCY LUNDEBJERG. 55 00:02:31,133 --> 00:02:33,035 I'M THE CHIEF EXECUTIVE OFFICER 56 00:02:33,035 --> 00:02:34,537 OF THE AMERICAN GERIATRICS 57 00:02:34,537 --> 00:02:35,304 SOCIETY. 58 00:02:35,304 --> 00:02:38,974 >> DR. REUBEN. 59 00:02:38,974 --> 00:02:41,410 >> I'M DAVE REUBEN, A 60 00:02:41,410 --> 00:02:43,045 GERIATRICIAN AND CHIEF OF 61 00:02:43,045 --> 00:02:44,347 GERIATRICS AT UCLA. 62 00:02:44,347 --> 00:02:47,683 >> AND DR. SCHNEIDER. 63 00:02:47,683 --> 00:02:49,452 >> HELLO, I'M DR. SCHNEIDER. 64 00:02:49,452 --> 00:02:52,688 I'M A PROFESSOR OF NEUROLOGY AND 65 00:02:52,688 --> 00:02:53,989 NEUROPATHOLOGY AT RUSH, WHERE I 66 00:02:53,989 --> 00:02:55,424 ALSO DIRECT THE ALZHEIMER'S 67 00:02:55,424 --> 00:02:56,859 DISEASE RESEARCH CENTER. 68 00:02:56,859 --> 00:02:59,462 >> AND DR. VAN ELDIK. 69 00:02:59,462 --> 00:03:01,764 >> HI, I'M LINDA VAN ELDIK. 70 00:03:01,764 --> 00:03:03,499 I'M AT UNIVERSITY OF KENTUCKY, 71 00:03:03,499 --> 00:03:07,536 WHERE I AM THE DIRECTOR OF THE 72 00:03:07,536 --> 00:03:09,739 CENTER ON AGING AND THE 73 00:03:09,739 --> 00:03:10,373 ALZHEIMER'S RESEARCH CENTER. 74 00:03:10,373 --> 00:03:14,610 >> AND OUR EX-OFFICIO MEMBERS, 75 00:03:14,610 --> 00:03:25,421 FR --MR. H WESTIN, NOT ON YET, D 76 00:03:25,788 --> 00:03:26,122 DR. HOLAVANAHALLI. 77 00:03:26,122 --> 00:03:27,456 >> GOOD MORNING, EVERYBODY. 78 00:03:27,456 --> 00:03:32,261 APOLOGIES FOR NOT BEING THERE IN 79 00:03:32,261 --> 00:03:34,563 PERSON, CARE DUTIES FOR TWO 80 00:03:34,563 --> 00:03:35,431 PERSONS IN THE FAMILY. 81 00:03:35,431 --> 00:03:37,199 I AM A REHABILITATION SPECIALIST 82 00:03:37,199 --> 00:03:41,070 AND A PROJECT OFFICER AT THE 83 00:03:41,070 --> 00:03:42,772 NATIONAL INSTITUTE ON DISABILITY 84 00:03:42,772 --> 00:03:43,239 INDEPENDENT LIVING AND 85 00:03:43,239 --> 00:03:44,206 REHABILITATION RESEARCH. 86 00:03:44,206 --> 00:03:45,941 WITHIN THE ADMINISTRATION FOR 87 00:03:45,941 --> 00:03:46,342 COMMUNITY LIVING. 88 00:03:46,342 --> 00:03:48,377 THANK YOU. 89 00:03:48,377 --> 00:03:49,678 >> THANK YOU. 90 00:03:49,678 --> 00:03:55,251 AND OUR AD HOC MEMBERS, 91 00:03:55,251 --> 00:03:56,018 DR. EPEL? 92 00:03:56,018 --> 00:03:58,521 SHE WILL BE JOINING US LATER. 93 00:03:58,521 --> 00:04:01,056 AND DR. HUMMER? 94 00:04:01,056 --> 00:04:02,358 >> HI, EVERYBODY. 95 00:04:02,358 --> 00:04:06,495 I'M BOB HUMMER, PROFESSOR OF 96 00:04:06,495 --> 00:04:08,764 SOCIOLOGY AT THE UNIVERSITY OF 97 00:04:08,764 --> 00:04:10,299 NORTH CAROLINA, CHAPEL HILL. 98 00:04:10,299 --> 00:04:11,967 >> AND I SEE DR. CRUZ HAS JOINED 99 00:04:11,967 --> 00:04:12,635 US. 100 00:04:12,635 --> 00:04:13,602 DR. CRUZ, WOULD YOU LIKE TO 101 00:04:13,602 --> 00:04:16,472 INTRODUCE YOURSELF? 102 00:04:16,472 --> 00:04:21,043 >> HI, GOOD MORNING. 103 00:04:21,043 --> 00:04:24,146 ANITA CRUZ, NATIONAL COUNCIL ON 104 00:04:24,146 --> 00:04:28,150 AGING GREAT TO BE HERE. 105 00:04:28,150 --> 00:04:29,251 >> THANK YOU, THANK YOU ALL. 106 00:04:29,251 --> 00:04:31,987 NOW I'LL TURN THE MEETING OVER 107 00:04:31,987 --> 00:04:34,089 TO OUR DIRECTOR, DR. RICHARD 108 00:04:34,089 --> 00:04:34,723 HODES. 109 00:04:34,723 --> 00:04:34,957 RICHARD? 110 00:04:34,957 --> 00:04:35,958 >> THANK YOU. 111 00:04:35,958 --> 00:04:37,560 ADD MY GOOD MORNING AND WELCOME, 112 00:04:37,560 --> 00:04:42,765 AND I'LL BE PROVIDING SOME 113 00:04:42,765 --> 00:04:43,799 COMMENTS, INFORMATION, AND THEN 114 00:04:43,799 --> 00:04:45,334 CERTAINLY AN OPPORTUNITY TO 115 00:04:45,334 --> 00:04:47,203 DISCUSS ANY OTHER TOPICS WITH 116 00:04:47,203 --> 00:04:48,771 YOU AT THE END OF THAT 117 00:04:48,771 --> 00:04:50,172 PRESENTATION. 118 00:04:50,172 --> 00:04:53,375 SO LET ME BEGIN I ON THE NEXT 119 00:04:53,375 --> 00:04:55,511 SLIDE, PLEASE, WITH AN IN 120 00:04:55,511 --> 00:05:03,285 MEMORIAM, SO WE HONOR HERE 121 00:05:03,285 --> 00:05:03,619 DR. HAEFLIK. 122 00:05:03,619 --> 00:05:04,787 WITH THE PASSING OF PREVIOUS 123 00:05:04,787 --> 00:05:06,555 MEMBERS OF COUNCIL, WE PAY 124 00:05:06,555 --> 00:05:07,656 SPECIAL ATTENTION AND HOMAGE. 125 00:05:07,656 --> 00:05:10,326 IN THIS CASE, LEONARD HAYFLICK 126 00:05:10,326 --> 00:05:11,694 WHO WAS A FOUNDING MEMBER FROM 127 00:05:11,694 --> 00:05:12,361 THE VERY BEGINNING. 128 00:05:12,361 --> 00:05:14,196 MANY OF YOU KNOW OF DR. HAY 129 00:05:14,196 --> 00:05:16,665 FLICK, I THINK AROUND 1961, HE 130 00:05:16,665 --> 00:05:18,133 WAS RESPONSIBLE FOR THE SEMINAL 131 00:05:18,133 --> 00:05:21,971 OBSERVATION THAT NORMAL 132 00:05:21,971 --> 00:05:23,606 NON-MALIGNANT CELLS WHY NOT 133 00:05:23,606 --> 00:05:26,242 IMMORTAL, THEY HAD A FINITE 134 00:05:26,242 --> 00:05:28,310 LIFESPAN, BEGINNING OUR 135 00:05:28,310 --> 00:05:29,211 UNDERSTANDING OF SENESCENCE AND 136 00:05:29,211 --> 00:05:30,279 REGULATION OF THE LIFESPAN. 137 00:05:30,279 --> 00:05:32,915 HE WAS PRESIDENT OF GSA, 138 00:05:32,915 --> 00:05:34,350 CHAIRMAN OF SCIENTIFIC REVIEW 139 00:05:34,350 --> 00:05:36,418 BOARD OF AFAR, EDITOR AND CHIEF 140 00:05:36,418 --> 00:05:37,820 OF EXPERIMENTAL GERONTOLOGY AND 141 00:05:37,820 --> 00:05:41,991 HAD POSITIONS AT STANFORD, 142 00:05:41,991 --> 00:05:44,393 OAKLAND, AND UCSF, SO TRULY 143 00:05:44,393 --> 00:05:48,230 ENORMOUS FIGURE IN OUR FIELD. 144 00:05:48,230 --> 00:05:49,665 WE CAN TAKE A MOMENT TO HONOR 145 00:05:49,665 --> 00:05:51,634 HIM, IF ANYONE HAS HAD CONTACT 146 00:05:51,634 --> 00:05:53,702 WITH LEONARD AND WANTS TO TALK 147 00:05:53,702 --> 00:05:57,740 TO HIM, PLEASE DO NOW, BUT A 148 00:05:57,740 --> 00:05:58,841 TRULY GREAT FIGURE IN THE FIELD 149 00:05:58,841 --> 00:05:59,508 AND IMPORTANT CONTRIBUTION TO 150 00:05:59,508 --> 00:06:08,017 OUR COMMUNITIES. 151 00:06:08,017 --> 00:06:09,752 WE'LL TURN NEXT TO INFORMATION 152 00:06:09,752 --> 00:06:12,421 ABOUT BUDGET AND APPROPRIATIONS. 153 00:06:12,421 --> 00:06:14,690 AS YOU PROBABLY ARE WELL AWARE, 154 00:06:14,690 --> 00:06:15,891 FY 2025 WILL BE UPON US IN A 155 00:06:15,891 --> 00:06:16,559 COUPLE OF WEEKS. 156 00:06:16,559 --> 00:06:18,460 THERE IS NOT AN APPROPRIATION 157 00:06:18,460 --> 00:06:19,662 THAT HAS BEEN PASSED. 158 00:06:19,662 --> 00:06:21,697 THIS HAS BEEN THE MORE TYPICAL 159 00:06:21,697 --> 00:06:22,698 SITUATION OVER THE PAST YEARS 160 00:06:22,698 --> 00:06:23,999 AND DECADES. 161 00:06:23,999 --> 00:06:26,402 IN THIS CASE, THE HOUSE 162 00:06:26,402 --> 00:06:30,005 APPROPRIATIONS BILL PASSED IN 163 00:06:30,005 --> 00:06:34,643 JULY, WOULD HAVE PROVIDED 164 00:06:34,643 --> 00:06:35,911 $48.5 BILLION FOR NIH, 165 00:06:35,911 --> 00:06:38,213 ESSENTIALLY FAT RELATIVE TO THIS 166 00:06:38,213 --> 00:06:39,648 YEAR. 167 00:06:39,648 --> 00:06:40,182 INTERESTINGLY, THERE WAS 168 00:06:40,182 --> 00:06:42,484 ALLOCATION OF $4.5 BILLION FOR 169 00:06:42,484 --> 00:06:43,752 THE NATIONAL INSTITUTE ON 170 00:06:43,752 --> 00:06:44,119 DEMENTIA. 171 00:06:44,119 --> 00:06:48,257 YOU MAY ALSO HAVE NOTED THERE 172 00:06:48,257 --> 00:06:49,925 WAS LANGUAGE NOT FROM 173 00:06:49,925 --> 00:06:52,761 APPROPRIATION BUT FROM ENC THAT 174 00:06:52,761 --> 00:06:54,630 PROPOSE ADD REORGANIZATION OF 175 00:06:54,630 --> 00:06:55,698 THE INSTITUTES AT NIH. 176 00:06:55,698 --> 00:06:58,033 WE HAVE OF COURSE NO IDEA IF OR 177 00:06:58,033 --> 00:06:59,902 WHEN THIS WILL TRANSLATE, BUT IT 178 00:06:59,902 --> 00:07:01,170 IS REFLECTED IN THE FACT THAT 179 00:07:01,170 --> 00:07:04,239 THE BUDGET FROM THE HOUSE 180 00:07:04,239 --> 00:07:04,773 APPROPRIATIONS HAVE AN 181 00:07:04,773 --> 00:07:06,742 ALLOCATION FOR THE NATIONAL 182 00:07:06,742 --> 00:07:07,743 INSTITUTE ON DEMENTIA, WHICH 183 00:07:07,743 --> 00:07:10,245 WOULD BE A SLIGHT INCREASE ABOVE 184 00:07:10,245 --> 00:07:11,780 THE NIA APPROPRIATION THIS YEAR. 185 00:07:11,780 --> 00:07:12,915 THEN FROM THE SENATE, IN AUGUST, 186 00:07:12,915 --> 00:07:14,950 THERE WAS A BILL THAT DID 187 00:07:14,950 --> 00:07:17,286 INCREASE BY ABOUT $2 BILLION THE 188 00:07:17,286 --> 00:07:21,624 OVERALL NIH BUDGET, FOR NIA, 189 00:07:21,624 --> 00:07:22,524 $4.6 BILLION WHICH WAS AN 190 00:07:22,524 --> 00:07:24,927 INCREASE OF $137.5 MILLION. 191 00:07:24,927 --> 00:07:26,962 THAT TARGETED FOR ALZHEIMER'S 192 00:07:26,962 --> 00:07:34,203 DISEASE AND NOTABLY WITH ANOTHER 193 00:07:34,203 --> 00:07:35,738 $137 MILLION FOR PALSY FOR 194 00:07:35,738 --> 00:07:37,773 NINDS, PROVIDING $12.5 MILLION 195 00:07:37,773 --> 00:07:38,907 IN ADDITION TO NIA FOR 196 00:07:38,907 --> 00:07:39,475 PALLIATIVE CARE. 197 00:07:39,475 --> 00:07:42,311 WE AS YOU KNOW AFTER A FAILED 198 00:07:42,311 --> 00:07:44,380 VOTE YESTERDAY, I BELIEVE MOST 199 00:07:44,380 --> 00:07:47,583 RECENTLY IN THE HOUSE, WE'RE 200 00:07:47,583 --> 00:07:49,618 WATCHING DAY BY DAY, WITH OF 201 00:07:49,618 --> 00:07:50,786 COURSE A STRONG LIKELIHOOD THAT 202 00:07:50,786 --> 00:07:52,488 WE'LL BE HAVING A CONTINUING 203 00:07:52,488 --> 00:07:54,456 RESOLUTION, WE HOPE WITHOUT ANY 204 00:07:54,456 --> 00:07:58,293 LAPSE IN FUNDING. 205 00:07:58,293 --> 00:08:01,130 IN TERMS OF THE NOW FINAL 206 00:08:01,130 --> 00:08:05,601 PAYLINES FOR RESEARCH, THIS 207 00:08:05,601 --> 00:08:08,771 CURRENT NEAR ENDING FISCAL YEAR 208 00:08:08,771 --> 00:08:09,772 2024, ONE IMPORTANT THING TO 209 00:08:09,772 --> 00:08:11,740 NOTE AS WE STEP BACK AND LOOK AT 210 00:08:11,740 --> 00:08:14,910 IT GLOBALLY IS THERE ARE NOW A 211 00:08:14,910 --> 00:08:15,678 VERY SMALL DIFFERENCE BETWEEN 212 00:08:15,678 --> 00:08:21,583 THE PAY LINES FOR TARGETED ADRD 213 00:08:21,583 --> 00:08:23,886 RESEARCH, FOR THE GENERAL 214 00:08:23,886 --> 00:08:24,753 PAYLINE MOST FREQUENT 215 00:08:24,753 --> 00:08:26,722 APPLICATIONS THAT IS LESS THAN 216 00:08:26,722 --> 00:08:28,590 $500,000 IN DIRECT COSTS, THE 217 00:08:28,590 --> 00:08:31,960 PAYLINE WAS THE 16TH PERCENTILE. 218 00:08:31,960 --> 00:08:36,799 AS UNUSUAL, WITH IMPROVED 219 00:08:36,799 --> 00:08:38,000 PAYLINES FOR NEW INVESTIGATORS 220 00:08:38,000 --> 00:08:42,037 OR NEW TO NIH SUPPORT, OR 221 00:08:42,037 --> 00:08:42,805 ESIs, INVESTIGATORS NEW IN 222 00:08:42,805 --> 00:08:44,773 TERMS OF THEIR EDUCATION AND 223 00:08:44,773 --> 00:08:45,240 TRAINING. 224 00:08:45,240 --> 00:08:48,477 IN PRIOR YEARS, WE HAD A 225 00:08:48,477 --> 00:08:51,113 5 PERCENTILE DIFFERENCE BETWEEN 226 00:08:51,113 --> 00:08:53,082 THE GENERAL PAYLINE AND THAT FOR 227 00:08:53,082 --> 00:08:53,849 ESI. 228 00:08:53,849 --> 00:08:55,484 AS YOU'LL NOTE THIS YEAR IT'S 229 00:08:55,484 --> 00:08:56,752 HIGHER STILL AS WE CONTINUE TO, 230 00:08:56,752 --> 00:08:58,654 IN FACT, INTENSIFY OUR SUPPORT 231 00:08:58,654 --> 00:09:01,957 OF EARLY STAGE INVESTIGATORS. 232 00:09:01,957 --> 00:09:03,158 ALTHOUGH NOT SHOWN AS A PAYLINE 233 00:09:03,158 --> 00:09:04,460 BECAUSE THERE'S NOT A FORMAL 234 00:09:04,460 --> 00:09:08,597 PAYLINE, WE ALSO GAVE PARTICULAR 235 00:09:08,597 --> 00:09:09,932 ATTENTION TO AT RISK 236 00:09:09,932 --> 00:09:11,800 INVESTIGATORS AS DEFINED BY 237 00:09:11,800 --> 00:09:14,636 THOSE THAT DID NOT RECEIVE THE 238 00:09:14,636 --> 00:09:15,304 CURRENT AWARD UNDER 239 00:09:15,304 --> 00:09:16,038 CONSIDERATION WOULD HAVE NO 240 00:09:16,038 --> 00:09:17,339 SUPPORT FOR THE LABORATORIES AND 241 00:09:17,339 --> 00:09:19,975 THEREFORE AT GREATER RISK. 242 00:09:19,975 --> 00:09:21,076 THE GENERAL PAYLINE AGAIN AS 243 00:09:21,076 --> 00:09:22,277 BEFORE, WE'VE HAD A HIGHER BAR 244 00:09:22,277 --> 00:09:24,913 FOR THE MORE EXPENSIVE 245 00:09:24,913 --> 00:09:26,648 APPLICATIONS. 246 00:09:26,648 --> 00:09:30,385 FOR AD/ADRD, LOWER EXPENSE 247 00:09:30,385 --> 00:09:31,920 DIRECT COST APPLICATIONS AGAIN, 248 00:09:31,920 --> 00:09:32,554 17TH PERCENTILE. 249 00:09:32,554 --> 00:09:34,423 SO NOT SO DIFFERENT FROM THE 250 00:09:34,423 --> 00:09:35,758 16TH PERCENTILE IN GENERAL 251 00:09:35,758 --> 00:09:35,991 PAYLINE. 252 00:09:35,991 --> 00:09:37,392 AND YOU CAN SATISFY 253 00:09:37,392 --> 00:09:38,794 CORRESPONDINGLY THE PREFERENTIAL 254 00:09:38,794 --> 00:09:42,164 PAYLINES FOR NEW AND EARLY STAGE 255 00:09:42,164 --> 00:09:42,498 INVESTIGATORS. 256 00:09:42,498 --> 00:09:43,832 AND NOW AS WE'VE INSTITUTED 257 00:09:43,832 --> 00:09:46,769 RECENTLY A HIGHER BAR FOR 258 00:09:46,769 --> 00:09:47,970 AD/ADRD AS WELL THE MORE 259 00:09:47,970 --> 00:09:49,505 EXPENSIVE APPLICATIONS IN THIS 260 00:09:49,505 --> 00:09:51,140 CASE THAT THRESHOLD BEING 261 00:09:51,140 --> 00:09:54,543 $5 MILLION. 262 00:09:54,543 --> 00:09:56,411 FOR NIA REVIEW OF APPLICATIONS 263 00:09:56,411 --> 00:09:58,580 WHICH DON'T RECEIVE A PERCENTILE 264 00:09:58,580 --> 00:09:59,681 BUT IMPACT PRIORITY SCORE, YOU 265 00:09:59,681 --> 00:10:02,084 CAN SEE HERE THE NUMBERS ARE 266 00:10:02,084 --> 00:10:07,890 SIMILAR FOR GENERAL AND ADRD, 267 00:10:07,890 --> 00:10:09,324 FOR CAREER DEVELOPMENT AND 268 00:10:09,324 --> 00:10:10,726 FELLOWSHIP AWARDS, SOME 269 00:10:10,726 --> 00:10:14,129 DIFFERENCE BETWEEN GENERAL AND 270 00:10:14,129 --> 00:10:15,898 AD/ADRD, 25 AND 30 FOR CAREER 271 00:10:15,898 --> 00:10:17,733 DEVELOPMENT AWARDS, 30 AND 35 272 00:10:17,733 --> 00:10:19,802 FOR FELLOWSHIP AWARDS, AGAIN 273 00:10:19,802 --> 00:10:21,570 REFLECTING A PRIORITY FOR 274 00:10:21,570 --> 00:10:22,905 MEETING OUR TRAINING AND CAREER 275 00:10:22,905 --> 00:10:26,809 DEVELOPMENT. 276 00:10:26,809 --> 00:10:29,978 SO THE PROFESSIONAL JUDGMENT 277 00:10:29,978 --> 00:10:34,583 BUDGET FOR ALZHEIMER'S DISEASE 278 00:10:34,583 --> 00:10:36,552 RESEARCH AS LEGISLATED FOR EACH 279 00:10:36,552 --> 00:10:38,187 YEAR THERE'S FISCAL 25, NEXT 280 00:10:38,187 --> 00:10:39,221 YEAR COMING UP, WE'RE REQUIRED 281 00:10:39,221 --> 00:10:41,023 TO SUBMIT A PROFESSIONAL 282 00:10:41,023 --> 00:10:43,325 JUDGMENT BUDGET TO CONGRESS. 283 00:10:43,325 --> 00:10:44,760 THERE IS UNDER CONSIDERATION AN 284 00:10:44,760 --> 00:10:46,929 EXTENSION OF THIS LEGISLATION 285 00:10:46,929 --> 00:10:54,036 THROUGH 2035. 286 00:10:54,036 --> 00:10:55,204 THE PROCESS YOU CAN SEE HERE IS 287 00:10:55,204 --> 00:10:58,006 ONE IN WHICH WE HOLD A SERIES OF 288 00:10:58,006 --> 00:11:01,143 MEETINGS, ACADEMIC INPUTS, ALL 289 00:11:01,143 --> 00:11:05,214 OF OUR VARIOUS CONSTITUENT 290 00:11:05,214 --> 00:11:06,682 AUDIENCES. 291 00:11:06,682 --> 00:11:08,050 EXCUSE ME, DRY MOUTH, I'VE 292 00:11:08,050 --> 00:11:09,051 TALKED TOO MUCH ALREADY THIS 293 00:11:09,051 --> 00:11:09,284 MORNING. 294 00:11:09,284 --> 00:11:11,553 THEN WE DEVELOPED MILESTONES 295 00:11:11,553 --> 00:11:15,724 BASED ON ALL THESE INPUTS FOR 296 00:11:15,724 --> 00:11:16,692 PRIORITIES, GAPS AND 297 00:11:16,692 --> 00:11:17,025 OPPORTUNITIES. 298 00:11:17,025 --> 00:11:20,629 THESE ARE THEN TRANSLATED INTO 299 00:11:20,629 --> 00:11:21,597 MILESTONES, THAT IS, WHAT NEEDS 300 00:11:21,597 --> 00:11:22,831 TO BE ACCOMPLISHED TO MEET THE 301 00:11:22,831 --> 00:11:24,566 GOALS OF PROFESSIONAL JUDGMENT 302 00:11:24,566 --> 00:11:26,001 BUDGET, AND THEN AN ESTIMATE OF 303 00:11:26,001 --> 00:11:28,604 THE COSTS, DOLLARS NEEDED, ABOVE 304 00:11:28,604 --> 00:11:30,372 CURRENT FUNDING LEVELS IN ORDER 305 00:11:30,372 --> 00:11:32,341 TO ACHIEVE THOSE PRIORITIES, AND 306 00:11:32,341 --> 00:11:34,409 THAT GENERATES THE FINAL 307 00:11:34,409 --> 00:11:40,749 PROFESSIONAL JUDGMENT BUDGET. 308 00:11:40,749 --> 00:11:42,517 JUST COMPLETED NOW, IN 2024, IS 309 00:11:42,517 --> 00:11:44,453 THE ESTIMATE FOR 2026, AND THIS 310 00:11:44,453 --> 00:11:46,455 IS TYPICAL OF THE LEAD TIME FOR 311 00:11:46,455 --> 00:11:49,958 THESE BUDGETS. 312 00:11:49,958 --> 00:11:51,627 SO THE FRAMEWORK FOR DEFINING 313 00:11:51,627 --> 00:11:56,531 THESE MILESTONES AND CATEGORIES 314 00:11:56,531 --> 00:12:00,369 ARE THE EIGHT CADRO CATEGORIES, 315 00:12:00,369 --> 00:12:02,004 AN ONTOLOGY ESTABLISHED BY NIA 316 00:12:02,004 --> 00:12:03,005 IN COLLABORATION WITH THE 317 00:12:03,005 --> 00:12:05,073 ALZHEIMER'S ASSOCIATION TO 318 00:12:05,073 --> 00:12:07,709 CATEGORIZE RESEARCH RELATED TO 319 00:12:07,709 --> 00:12:08,677 ALZHEIMER'S RELATED DEMENTIAS, 320 00:12:08,677 --> 00:12:10,779 IS ALSO IN THE FRAMEWORK FOR THE 321 00:12:10,779 --> 00:12:12,281 INTERNATIONAL ALZHEIMER'S 322 00:12:12,281 --> 00:12:13,382 DISEASE RESEARCH PORTFOLIO, 323 00:12:13,382 --> 00:12:15,250 WHICH ALLOWS US TO TRACK 324 00:12:15,250 --> 00:12:16,318 IMPLEMENTATION ACROSS RESEARCH 325 00:12:16,318 --> 00:12:19,955 AREAS NATIONALLY AND GLOBALLY. 326 00:12:19,955 --> 00:12:22,524 AND IN THESE CATEGORIES, YOU CAN 327 00:12:22,524 --> 00:12:25,427 SEE HERE IN THE FY 26 328 00:12:25,427 --> 00:12:26,295 PROFESSIONAL JUDGMENT BUDGET, 329 00:12:26,295 --> 00:12:28,130 THE AMOUNTS ALLOCATED TO EACH OF 330 00:12:28,130 --> 00:12:29,998 THESE WHEN ADDED, THEY 331 00:12:29,998 --> 00:12:34,369 CORRESPOND TO A TOTAL OF ABOUT 332 00:12:34,369 --> 00:12:35,804 $445 MILLION ABOVE CURRENT 333 00:12:35,804 --> 00:12:37,439 RESOURCES. 334 00:12:37,439 --> 00:12:40,509 HOWEVER, WE HAVE NOW, MANY YEARS 335 00:12:40,509 --> 00:12:44,446 INTO OUR EXTENDED ALZHEIMER'S 336 00:12:44,446 --> 00:12:46,748 AND ADRD RESEARCH PROGRAM, EACH 337 00:12:46,748 --> 00:12:49,418 YEAR FUNDS BECOMING AVAILABLE 338 00:12:49,418 --> 00:12:50,285 FROM COMPLETION OF PROJECTS FROM 339 00:12:50,285 --> 00:12:50,686 PRIOR YEARS. 340 00:12:50,686 --> 00:12:54,189 THIS YEAR THAT AMOUNTED TO SOME 341 00:12:54,189 --> 00:12:54,823 $332 MILLION THAT WILL BECOME 342 00:12:54,823 --> 00:12:56,158 AVAILABLE FOR NEW RESEARCH, 343 00:12:56,158 --> 00:12:57,559 THEREFORE WE SUBTRACT THAT FROM 344 00:12:57,559 --> 00:13:00,262 THE TOTAL REQUEST OF 345 00:13:00,262 --> 00:13:01,196 $445 MILLION WITH A NET REQUEST 346 00:13:01,196 --> 00:13:03,532 FOR ADDITIONAL FUNDS OF 347 00:13:03,532 --> 00:13:07,402 $113 MILLION. 348 00:13:07,402 --> 00:13:12,207 THIS SHOWS THE IMPACT OF THAT ON 349 00:13:12,207 --> 00:13:16,712 THE TOTAL AD/ADRD RESEARCH AT 350 00:13:16,712 --> 00:13:22,084 NIH WHICH AT PRESENT IS 351 00:13:22,084 --> 00:13:23,085 $3.87 BILLION WITH THE INCREASE 352 00:13:23,085 --> 00:13:26,321 BEING ASKED WOULD COME TO 353 00:13:26,321 --> 00:13:30,058 3.98 OR VERY NEARLY $4 BILLION. 354 00:13:30,058 --> 00:13:32,127 THIS SHOWS YOU THE SAME IN A PIE 355 00:13:32,127 --> 00:13:33,428 DIAGRAM BREAKING IT OUT INTO 356 00:13:33,428 --> 00:13:35,230 PERCENTAGES IN THE VARIOUS 357 00:13:35,230 --> 00:13:42,304 CATEGORIES. 358 00:13:42,304 --> 00:13:43,605 IN ADDITION TO THE PROFESSIONAL 359 00:13:43,605 --> 00:13:44,940 JUDGMENT IN DOLLARS, THERE IS A 360 00:13:44,940 --> 00:13:46,575 NARRATIVE PROVIDED WITH EXAMPLES 361 00:13:46,575 --> 00:13:48,877 OF POTENTIAL FUTURE RESEARCH 362 00:13:48,877 --> 00:13:50,512 OPPORTUNITIES IN EACH OF THE SIX 363 00:13:50,512 --> 00:13:52,781 RESEARCH AREAS THAT ARE NOTED 364 00:13:52,781 --> 00:13:54,016 HERE AS WELL AS CROSS-CUTTING 365 00:13:54,016 --> 00:13:55,217 AREAS OF COMMUNITY ENGAGED 366 00:13:55,217 --> 00:13:57,519 RESEARCH. 367 00:13:57,519 --> 00:14:00,922 AND RECOMMEND VERY MUCH READING 368 00:14:00,922 --> 00:14:02,224 OF THIS OF THE NARRATIVE, AS 369 00:14:02,224 --> 00:14:03,191 WELL AS, OF COURSE, THE 370 00:14:03,191 --> 00:14:06,928 ATTENTION PAID TO THE DOLLARS. 371 00:14:06,928 --> 00:14:08,764 NEXT, IN ADDITION TO THE BYPASS 372 00:14:08,764 --> 00:14:10,632 BUDGET, THERE IS AN ALZHEIMER'S 373 00:14:10,632 --> 00:14:12,267 AND RELATED DEMENTIAS PROGRESS 374 00:14:12,267 --> 00:14:14,136 REPORT WHICH SUMMARIZES 375 00:14:14,136 --> 00:14:15,070 SIGNIFICANT ACHIEVEMENTS OVER 376 00:14:15,070 --> 00:14:18,073 THE PAST YEAR. 377 00:14:18,073 --> 00:14:20,575 HERE TOO, THEY'RE BROKEN DOWN 378 00:14:20,575 --> 00:14:22,878 INTO MANY EXAMPLES THAT ARE 379 00:14:22,878 --> 00:14:24,746 ILLUSTRATED HERE. 380 00:14:24,746 --> 00:14:28,350 WON'T READ NEM ALL THEM ALL BUY 381 00:14:28,350 --> 00:14:30,419 RANGE FROM UNDERSTANDING RISK 382 00:14:30,419 --> 00:14:32,954 AND PROTECTIVE FACTORS, 383 00:14:32,954 --> 00:14:35,357 ENHANCING DIVERSITY AND 384 00:14:35,357 --> 00:14:37,092 INCLUSION OF CLINICAL TRIALS. 385 00:14:37,092 --> 00:14:38,593 AND AGAIN WOULD REALLY RECOMMEND 386 00:14:38,593 --> 00:14:39,394 READING THROUGH THE PROGRESS 387 00:14:39,394 --> 00:14:40,395 REPORT WHICH IS A REAL TRIBUTE 388 00:14:40,395 --> 00:14:41,696 TO THE WORK THAT ALL OF YOU IN 389 00:14:41,696 --> 00:14:42,798 THE FIELD HAVE ACHIEVED OVER THE 390 00:14:42,798 --> 00:14:44,332 PAST YEARS AND NOTING OUR 391 00:14:44,332 --> 00:14:45,300 PROGRESS IN ADDITION TO OUR 392 00:14:45,300 --> 00:14:46,601 NEEDS AND PROJECTED PRIORITIES 393 00:14:46,601 --> 00:14:47,836 FOR YEARS TO COME. 394 00:14:47,836 --> 00:14:51,440 SOME UPDATES. 395 00:14:51,440 --> 00:14:53,708 AMONG ACTIVE NIA FUNDED 396 00:14:53,708 --> 00:14:55,744 ALZHEIMER'S RELATED DEMENTIAS 397 00:14:55,744 --> 00:14:58,280 CLINICAL TRIALS, THE TOTAL NOW 398 00:14:58,280 --> 00:15:01,917 IS SOME 461, THEY'RE BROKEN DOWN 399 00:15:01,917 --> 00:15:02,918 INTO THE CATEGORIES YOU SEE HERE 400 00:15:02,918 --> 00:15:04,686 AND IF WE SEE THE NEXT SLIDES, 401 00:15:04,686 --> 00:15:05,987 WE'LL BREAK THEM DOWN FURTHER 402 00:15:05,987 --> 00:15:06,188 STILL. 403 00:15:06,188 --> 00:15:09,091 SO FOR THE ACTIVE CLINICAL 404 00:15:09,091 --> 00:15:12,094 TRIALS, PHARMACOLOGIC AND 405 00:15:12,094 --> 00:15:13,195 NON-PHARMACOLOGIC, 67 406 00:15:13,195 --> 00:15:14,830 PHARMACOLOGIC TRIALS BROKEN DOWN 407 00:15:14,830 --> 00:15:16,798 INTO 54, WHICH ARE THE EARLIER 408 00:15:16,798 --> 00:15:18,433 PHASE, PHASE 1 AND PHASE 409 00:15:18,433 --> 00:15:23,371 2 TRIALS, AND THEN 13, PHASE 2, 410 00:15:23,371 --> 00:15:24,339 3, 3 AND 4 TRIALS. 411 00:15:24,339 --> 00:15:26,908 NOTED HERE ARE THE CATEGORIES OR 412 00:15:26,908 --> 00:15:28,410 TARGETS FOR THESE STUDIES, AND 413 00:15:28,410 --> 00:15:29,644 FOR THOSE WHO HAVE BEEN TRACKING 414 00:15:29,644 --> 00:15:32,781 OVER THE PAST YEARS, YOU CAN SEE 415 00:15:32,781 --> 00:15:35,083 THE VERY NOTABLE TREND TOWARDS 416 00:15:35,083 --> 00:15:35,851 DIVERSIFICATION OF TARGETS, 417 00:15:35,851 --> 00:15:37,352 WHICH IS A DIRECT PRODUCT OF THE 418 00:15:37,352 --> 00:15:39,454 BASIC RESEARCH AND TRANSLATIONAL 419 00:15:39,454 --> 00:15:40,555 RESEARCH THAT HAS LED TO AN 420 00:15:40,555 --> 00:15:41,756 APPRECIATION OF THE PATHWAYS 421 00:15:41,756 --> 00:15:43,158 INVOLVED IN ALZHEIMER'S RELATED 422 00:15:43,158 --> 00:15:44,025 DEMENTIAS AND TRANSLATION OF 423 00:15:44,025 --> 00:15:46,027 THAT INTO CLINICAL TRIALS AMONG 424 00:15:46,027 --> 00:15:51,800 THOSE MORE DIVERSE TARGETS. 425 00:15:51,800 --> 00:15:54,803 NOTABLY FOR THE PHASE 1, 426 00:15:54,803 --> 00:15:56,605 2 TRIALS, OF THE 54, ONLY SIX 427 00:15:56,605 --> 00:15:58,607 ARE DIRECTED AT AMYLOID, WHICH 428 00:15:58,607 --> 00:16:01,643 UNTIL RECENT YEARS HAD BEEN A 429 00:16:01,643 --> 00:16:02,844 VERY PREDOMINANT TARGET. 430 00:16:02,844 --> 00:16:03,712 REMAINS AN IMPORTANT ONE BUT IS 431 00:16:03,712 --> 00:16:05,046 NOW JOINED BY THESE OTHER 432 00:16:05,046 --> 00:16:06,248 PATHWAYS YOU CAN SEE, JUST AS 433 00:16:06,248 --> 00:16:08,550 EXAMPLES IN TERMS OF 434 00:16:08,550 --> 00:16:12,254 INFLAMMATION, RECEPTIVE 435 00:16:12,254 --> 00:16:13,889 TARGETING, VASCULATURE, ET 436 00:16:13,889 --> 00:16:17,726 CETERA, AND SIMILARLY FOR THE 13 437 00:16:17,726 --> 00:16:19,361 MORE ADVANCED PHASE 2, 3, 438 00:16:19,361 --> 00:16:21,096 4 TRIALS, OF THE 13, ONLY FOUR 439 00:16:21,096 --> 00:16:22,764 ARE DIRECTED AT AMYLOID. 440 00:16:22,764 --> 00:16:24,065 AGAIN STILL IMPORTANT, AN AREA 441 00:16:24,065 --> 00:16:26,301 WE'VE HAD DRAMATIC PRECEDENCE 442 00:16:26,301 --> 00:16:30,739 SETTING, BUT ALSO NOW WITH 443 00:16:30,739 --> 00:16:33,041 TRANSLATION OF EARLY AND EARLY 444 00:16:33,041 --> 00:16:34,242 STAGE CLINICAL TRIALS INTO THESE 445 00:16:34,242 --> 00:16:36,211 MORE LATE STAGE TRIALS OVER THE 446 00:16:36,211 --> 00:16:42,217 NEXT YEARS IN ANTICIPATION. 447 00:16:42,217 --> 00:16:44,085 TURNING TO THE 448 00:16:44,085 --> 00:16:45,720 NON-PHARMACOLOGICAL TRIALS, SOME 449 00:16:45,720 --> 00:16:49,324 152 OF THEM, AGAIN MULTIPLE -- 450 00:16:49,324 --> 00:16:50,659 COGNITIVE TRAINING AND ON 451 00:16:50,659 --> 00:16:51,526 THROUGH COMBINATIONS AND WE 452 00:16:51,526 --> 00:16:56,464 ANTICIPATE SEEING MORE AND MORE 453 00:16:56,464 --> 00:16:58,733 COMBINATIONS OF PHARM AND PHARM, 454 00:16:58,733 --> 00:17:01,169 PHARM AND NON-PHARM AS WE 455 00:17:01,169 --> 00:17:03,004 ADDRESS IN A MORE DETAILED WAY 456 00:17:03,004 --> 00:17:05,740 THE COMPLEXITY AND HETEROGENEITY 457 00:17:05,740 --> 00:17:06,975 OF WHAT HAPPENS AT RISK DURING 458 00:17:06,975 --> 00:17:08,343 THE PROGRESSION OF ALZHEIMER'S 459 00:17:08,343 --> 00:17:09,477 DISEASE AND ADDRESS THOSE WITH 460 00:17:09,477 --> 00:17:17,686 INTERVENTIONS. 461 00:17:17,686 --> 00:17:18,653 SIMILARLY IN THE AREA OF 462 00:17:18,653 --> 00:17:21,690 DEMENTIA CARE AND CAREGIVING, 463 00:17:21,690 --> 00:17:25,860 DIVERSITY OF TARGETS NOW WITH A 464 00:17:25,860 --> 00:17:27,062 SMALLER NUMBER OF THOSE 465 00:17:27,062 --> 00:17:28,263 ADVANCING INTO REALLY 466 00:17:28,263 --> 00:17:29,130 DEMONSTRATION PROJECTS WHERE 467 00:17:29,130 --> 00:17:31,433 THEY'RE BEING IMPLEMENTED MORE 468 00:17:31,433 --> 00:17:32,467 WIDELY, NEED FOR CONTINUED 469 00:17:32,467 --> 00:17:33,535 EVALUATION OF THEIR SUCCESSES 470 00:17:33,535 --> 00:17:35,503 AND COMMITMENT JUST AS THERE IS 471 00:17:35,503 --> 00:17:38,106 FOR LOOKING AT MEANS OF 472 00:17:38,106 --> 00:17:39,007 PREVENTING AND TREATING 473 00:17:39,007 --> 00:17:39,641 ALZHEIMER'S DISEASE FOR TENDING 474 00:17:39,641 --> 00:17:42,310 TO THE CARE AND CAREGIVING NEEDS 475 00:17:42,310 --> 00:17:43,578 AT PRESENT. 476 00:17:43,578 --> 00:17:45,880 AND IN YEARS TO COME. 477 00:17:45,880 --> 00:17:47,215 IN ADDITION, THERE ARE 478 00:17:47,215 --> 00:17:50,585 CATEGORIES HERE OF DIAGNOSTIC 479 00:17:50,585 --> 00:17:53,121 AND BIOMARKERS, TREATMENT OF THE 480 00:17:53,121 --> 00:17:54,522 NEUROPSYCHIATRIC SYMPTOMS THAT 481 00:17:54,522 --> 00:17:55,090 ACCOMPANY DEMENTIAS. 482 00:17:55,090 --> 00:17:56,258 THE TOTAL NUMBER OF TRIALS 483 00:17:56,258 --> 00:17:58,593 OVERALL AS YOU CAN SEE SOME 484 00:17:58,593 --> 00:18:06,134 461 AND AGAIN, THAT'S JUST NIA, 485 00:18:06,134 --> 00:18:09,304 A D/ADRD TRIALS. 486 00:18:09,304 --> 00:18:10,605 GLOBALLY IT'S OF COURSE FAR 487 00:18:10,605 --> 00:18:11,339 GREATER. 488 00:18:11,339 --> 00:18:14,509 AMONG THE CONGRESSIONAL LANGUAGE 489 00:18:14,509 --> 00:18:17,946 IN THE FY 22 APPROPRIATIONS WAS 490 00:18:17,946 --> 00:18:21,883 THE DIRECTION TO NIA, WORKING 491 00:18:21,883 --> 00:18:23,518 WITH NINDS TO ENTER INTO AN 492 00:18:23,518 --> 00:18:25,053 AGREEMENT WITH THE NATIONAL 493 00:18:25,053 --> 00:18:27,355 ACADEMIES TO WITHIN 60 DAYS OF 494 00:18:27,355 --> 00:18:30,759 ENACTMENT TO IDENTIFY A PROCESS 495 00:18:30,759 --> 00:18:32,694 FOR EXAMINING PRIORITIES FOR 496 00:18:32,694 --> 00:18:34,996 RESEARCH AIMED AT PREVENTING AND 497 00:18:34,996 --> 00:18:36,197 TREATING AD/ADRD. 498 00:18:36,197 --> 00:18:37,732 YOU CAN SEE THE TIMETABLE HERE 499 00:18:37,732 --> 00:18:40,935 IN FY 23, A TASK ORDER WAS 500 00:18:40,935 --> 00:18:43,972 ESTABLISHED WITH THE NATIONAL 501 00:18:43,972 --> 00:18:44,572 ACADEMY, COMMITTEE WAS 502 00:18:44,572 --> 00:18:45,940 ESTABLISHED IN SEPTEMBER OF LAST 503 00:18:45,940 --> 00:18:47,275 YEAR, THEN IN THE PAST YEAR A 504 00:18:47,275 --> 00:18:49,444 SERIES OF PUBLIC MEETINGS AND 505 00:18:49,444 --> 00:18:50,545 CLOSED SESSIONS WITH AN 506 00:18:50,545 --> 00:18:52,080 EXPECTATION OF THE FINAL REPORT 507 00:18:52,080 --> 00:18:54,916 ANTICIPATED IN THE EARLY MONTHS 508 00:18:54,916 --> 00:18:55,350 OF 2025. 509 00:18:55,350 --> 00:18:56,885 AND OF COURSE THERE WILL BE 510 00:18:56,885 --> 00:18:58,920 ANOTHER IMPORTANT BIT OF INPUT 511 00:18:58,920 --> 00:19:02,590 GUIDING OUR IDENTIFICATION M OFF 512 00:19:02,590 --> 00:19:08,396 PRIORITIES FOR FUTURE RESEARCH. 513 00:19:08,396 --> 00:19:10,265 PUTTING IN SOME RECENT EVENTS 514 00:19:10,265 --> 00:19:12,801 JUST A COUPLE DAYS AGO, IT WAS A 515 00:19:12,801 --> 00:19:14,302 GREAT OPPORTUNITY TO BE ABLE TO 516 00:19:14,302 --> 00:19:17,672 PARTICIPATE WITH ATUL GAWANDE IN 517 00:19:17,672 --> 00:19:19,441 AN EVENT SPONSORED THROUGH THE 518 00:19:19,441 --> 00:19:20,642 FOGARTY INTERNATIONAL CENTER 519 00:19:20,642 --> 00:19:24,779 LOOKING AT USAID, NIA 520 00:19:24,779 --> 00:19:26,648 PERSPECTIVES ON AGING, 521 00:19:26,648 --> 00:19:28,083 LONGEVITY, AND REALLY THE THEME 522 00:19:28,083 --> 00:19:30,251 OF WHICH OVERALL WAS TO 523 00:19:30,251 --> 00:19:31,353 UNDERSTAND WHAT THE IMPORTANCE 524 00:19:31,353 --> 00:19:35,290 WAS OF DOING GLOBAL 525 00:19:35,290 --> 00:19:37,058 INTERNATIONAL RESEARCH ON THESE 526 00:19:37,058 --> 00:19:38,793 THEMES. 527 00:19:38,793 --> 00:19:41,863 WE ARE IN THE PROCESS OF GENERAL 528 00:19:41,863 --> 00:19:45,667 GENERATING A NEXT NIA STRATEGIC 529 00:19:45,667 --> 00:19:46,568 DIRECTIONS DOCUMENT, IT'S COME 530 00:19:46,568 --> 00:19:48,536 UP IN SOME OF OUR CONVERSATIONS 531 00:19:48,536 --> 00:19:49,304 WITH COUNCIL YESTERDAY AS WELL. 532 00:19:49,304 --> 00:19:51,106 YOU CAN SEE THE SCHEDULE HERE, 533 00:19:51,106 --> 00:19:54,976 THERE WAS AN RFI RELEASED WHICH 534 00:19:54,976 --> 00:19:56,611 CLOSED ON SEPTEMBER 13TH BUT AS 535 00:19:56,611 --> 00:19:58,046 NOTED THERE WILL BE OPPORTUNITY 536 00:19:58,046 --> 00:19:59,581 FOR FURTHER INPUT BY 537 00:19:59,581 --> 00:20:00,782 SPECIFICALLY COUNCIL AND 538 00:20:00,782 --> 00:20:02,984 COUNCILMEMBERS AS WELL. 539 00:20:02,984 --> 00:20:05,754 THIS COMPLEMENTS MA MANY OF OUR 540 00:20:05,754 --> 00:20:07,222 MORE TARGETED SPECIFIC PLANNING 541 00:20:07,222 --> 00:20:10,091 APPROACHES AND PROVIDES OUR MOST 542 00:20:10,091 --> 00:20:11,159 GENERAL DIRECTION FOR 543 00:20:11,159 --> 00:20:12,160 ESTABLISHING RESEARCH PRIORITIES 544 00:20:12,160 --> 00:20:19,434 OVER THE SUBSEQUENT FIVE YEARS. 545 00:20:19,434 --> 00:20:20,869 COMMITMENT TO COMMUNICATING AND 546 00:20:20,869 --> 00:20:23,471 DISSEMINATING RESULTS OF NIA 547 00:20:23,471 --> 00:20:26,007 SUPPORTED RESEARCH ARE 548 00:20:26,007 --> 00:20:27,976 ILLUSTRATED HERE SINCE MAY, OUR 549 00:20:27,976 --> 00:20:31,579 LAST COUNCIL MEETINGS. 550 00:20:31,579 --> 00:20:33,314 THE RESEARCH HIGHLIGHTS HAVE 551 00:20:33,314 --> 00:20:36,050 BEEN PUBLISHED, 14 BLOGS, NEWS 552 00:20:36,050 --> 00:20:37,719 ANNOUNCEMENTS, SINCE MAY, 553 00:20:37,719 --> 00:20:40,422 MYSELF, AMY KELLEY AND OTHER 554 00:20:40,422 --> 00:20:42,524 SENIOR STAFF PARTICIPATED IN 14 555 00:20:42,524 --> 00:20:43,825 MEETINGS WITH INTEREST IN 556 00:20:43,825 --> 00:20:45,460 ADVOCACY GROUPS AND SOME FIVE 557 00:20:45,460 --> 00:20:46,561 CONGRESSIONAL BRIEFINGS AND 558 00:20:46,561 --> 00:20:47,529 HEARINGS. 559 00:20:47,529 --> 00:20:47,862 ANNOUNCEMENTS. 560 00:20:47,862 --> 00:20:51,499 ONCE AGAIN, WANT TO FEATURE FOR 561 00:20:51,499 --> 00:20:54,669 YOU THIS USE OF MECHANISMS FOR 562 00:20:54,669 --> 00:20:57,272 START YUM CHALLENGE TO PROMOTE 563 00:20:57,272 --> 00:21:00,575 HEALTHY AGING. 564 00:21:00,575 --> 00:21:02,644 THE FIRST IN 2022, THE SECOND IN 565 00:21:02,644 --> 00:21:03,611 2023, ILLUSTRATED HERE WHAT SOME 566 00:21:03,611 --> 00:21:07,015 OF THE WINNERS WERE IN 2023. 567 00:21:07,015 --> 00:21:08,550 YOU'LL RECALL FROM PREVIOUS 568 00:21:08,550 --> 00:21:12,153 DESCRIPTIONS, THIS PROVIDES SORT 569 00:21:12,153 --> 00:21:14,255 OF A SHARK TANK FOR PROPOSALS 570 00:21:14,255 --> 00:21:16,191 BUT THEY'RE NOT JUST JUDGED. 571 00:21:16,191 --> 00:21:18,493 THE PARTICIPANTS WHO SUBMIT THEM 572 00:21:18,493 --> 00:21:20,094 HAVE THE ADVANTAGE OF WORKING 573 00:21:20,094 --> 00:21:20,995 WITH ENTREPRENEURIAL EXPERTS TO 574 00:21:20,995 --> 00:21:22,330 HONE SKILLS IN TRANSLATING FROM 575 00:21:22,330 --> 00:21:23,765 RESEARCH INTO WHAT IT TAKES TO 576 00:21:23,765 --> 00:21:26,267 HAVE PRODUCTS OF THAT RESEARCH 577 00:21:26,267 --> 00:21:28,136 BECOME MARKETABLE AND HELP TO 578 00:21:28,136 --> 00:21:32,073 ADVANCE HEALTHY AGING. 579 00:21:32,073 --> 00:21:33,475 HERE YOU CAN SEE ILLUSTRATED THE 580 00:21:33,475 --> 00:21:36,211 SUCSIX WINNERS. 581 00:21:36,211 --> 00:21:37,946 JUST TO NOTE THE RANGE OF 582 00:21:37,946 --> 00:21:40,014 PROJECTS THAT WERE SUPPORTED, 583 00:21:40,014 --> 00:21:42,684 THE FIRST M MECHANICALLY POWERED 584 00:21:42,684 --> 00:21:44,219 ASSISTED WALKING DEVICES FOR 585 00:21:44,219 --> 00:21:45,954 ACCESSIBLE MOBILITY 586 00:21:45,954 --> 00:21:47,489 REHABILITATION, THROUGH 587 00:21:47,489 --> 00:21:50,458 IMPLANTABLE MEDICAL DEVICES TO 588 00:21:50,458 --> 00:21:52,393 TREAT CARDIOVASCULAR CONDITIONS, 589 00:21:52,393 --> 00:21:53,995 AND ON THROUGH A VARIETY OF 590 00:21:53,995 --> 00:21:55,597 DISCIPLINES AND AREAS. 591 00:21:55,597 --> 00:21:57,765 THE 2025 STARTUP WAS LAUNCHED IN 592 00:21:57,765 --> 00:21:58,867 SEPTEMBER AND SUBMISSIONS ARE 593 00:21:58,867 --> 00:22:01,069 DUE IN DECEMBER. 594 00:22:01,069 --> 00:22:03,238 AND THIS, AGAIN, IS A MECHANISM 595 00:22:03,238 --> 00:22:05,540 THAT'S VERY EFFECTIVE IN 596 00:22:05,540 --> 00:22:06,341 RECRUITING INTO RESEARCH 597 00:22:06,341 --> 00:22:07,942 INDIVIDUALS AND PROJECTS AND 598 00:22:07,942 --> 00:22:09,577 DIRECTIONS WHICH ARE NOT TYPICAL 599 00:22:09,577 --> 00:22:12,213 OF AND, THEREFORE, EXTEND BEYOND 600 00:22:12,213 --> 00:22:13,848 OUR USUAL RESEARCH SUPPORT 601 00:22:13,848 --> 00:22:17,986 MECHANISMS. 602 00:22:17,986 --> 00:22:21,389 THERE WILL BE, NEXT WEEK, FALLS 603 00:22:21,389 --> 00:22:23,691 PREVENTION IN OLDER ADULTS, 604 00:22:23,691 --> 00:22:24,893 EXPERT Q & A FOR THOSE OF YOU 605 00:22:24,893 --> 00:22:29,264 WHO CAN MAKE IT. 606 00:22:29,264 --> 00:22:33,735 AGAIN, NEXT WEEK THE 2024 NIH 607 00:22:33,735 --> 00:22:34,736 ALZHEIMER'S RESEARCH SUMMIT HELD 608 00:22:34,736 --> 00:22:37,038 HERE ON CAMPUS, BUT HYBRID AS 609 00:22:37,038 --> 00:22:37,572 WELL. 610 00:22:37,572 --> 00:22:40,742 REGISTRATION IS NOW OPEN, THOSE 611 00:22:40,742 --> 00:22:42,710 WHO WANT TO SIGN ON FOR REMOTE 612 00:22:42,710 --> 00:22:43,578 VIEWING, WE'D ENCOURAGE YOU TO 613 00:22:43,578 --> 00:22:44,145 DO SO. 614 00:22:44,145 --> 00:22:46,114 THESE ARE IMPORTANT SUPPLEMENTS 615 00:22:46,114 --> 00:22:49,717 THAT OCCUR, THERE'S THIS, THE 616 00:22:49,717 --> 00:22:50,585 ALZHEIMER'S RESEARCH SUMMIT, 617 00:22:50,585 --> 00:23:00,562 THERE'S AN ALZHEIMER'S RELATED 618 00:23:00,562 --> 00:23:03,498 SUMMIT, THIS ONE ON CARE AND 619 00:23:03,498 --> 00:23:03,831 CAREGIVING. 620 00:23:03,831 --> 00:23:05,466 WE AT THIS COUNCIL CONTINUE TO 621 00:23:05,466 --> 00:23:08,303 MARK OUR 50TH ANNIVERSARY SINCE 622 00:23:08,303 --> 00:23:09,404 1974 AND INVITE YOU AS YOU HAVE 623 00:23:09,404 --> 00:23:11,072 BEEN DOING SO WONDERFULLY AT THE 624 00:23:11,072 --> 00:23:12,040 LEVEL OF INDIVIDUALS, 625 00:23:12,040 --> 00:23:12,707 INSTITUTIONS AND ORGANIZATIONS 626 00:23:12,707 --> 00:23:15,443 TO HELP US CELEBRATE. 627 00:23:15,443 --> 00:23:15,977 WHAT WE ALL 628 00:23:15,977 --> 00:23:17,378 HAVE ACCOMPLISHED OVER THE PAST 629 00:23:17,378 --> 00:23:22,750 50 YEARS. 630 00:23:22,750 --> 00:23:24,819 AT THE NIH LEVEL, AND IF THERE 631 00:23:24,819 --> 00:23:27,221 ARE QUESTIONS TO THIS, I'LL 632 00:23:27,221 --> 00:23:29,757 HAPPILY TURN TO MY TRUSTED 633 00:23:29,757 --> 00:23:32,694 ESTEEMED COLLEAGUE KEN, AN 634 00:23:32,694 --> 00:23:33,928 OVERVIEW OF GRANT APPLICATION 635 00:23:33,928 --> 00:23:34,996 AND REVIEW CHANGES THAT WILL AND 636 00:23:34,996 --> 00:23:38,933 DO HAVE AN IMPACT, BUT 637 00:23:38,933 --> 00:23:41,135 SIMPLIFIED REVIEW FRAMEWORK 638 00:23:41,135 --> 00:23:42,337 AIMED TO FOCUS ON WHAT IS AND 639 00:23:42,337 --> 00:23:43,438 SHOULD BE MOST IMPORTANT, WHAT 640 00:23:43,438 --> 00:23:44,706 SHOULD BE EMPHASIZED IN REVIEW 641 00:23:44,706 --> 00:23:46,274 OF APPLICATIONS. 642 00:23:46,274 --> 00:23:47,909 THIS WILL APPLY FOR DUE TAITS 643 00:23:47,909 --> 00:23:49,110 AFTER MAY OF 2025. 644 00:23:49,110 --> 00:23:53,147 AND FINALLY, AS WE CELEBRATE 645 00:23:53,147 --> 00:23:55,683 STAFF UPDATE, AS YOU KNOW THE 646 00:23:55,683 --> 00:23:59,520 INSTITUTE HAS GROWN ENORMOUSLY, 647 00:23:59,520 --> 00:24:02,523 BRINGING MORE TALENTED PEOPLE 648 00:24:02,523 --> 00:24:04,092 AND STAFF TO WORK WITH US SO 649 00:24:04,092 --> 00:24:05,193 WE'LL TAKE THIS OCCASION TO HAVE 650 00:24:05,193 --> 00:24:06,394 EACH OF THE DIVISIONS TALK TO 651 00:24:06,394 --> 00:24:07,261 YOU ABOUT THE PEOPLE WHO HAVE 652 00:24:07,261 --> 00:24:08,029 JOINED US SINCE. 653 00:24:08,029 --> 00:24:09,864 AND WE'RE BEGINNING WITH -- 654 00:24:09,864 --> 00:24:12,100 >> DIVISION OF BEHAVIORAL AND 655 00:24:12,100 --> 00:24:13,401 SOCIAL RESEARCH. 656 00:24:13,401 --> 00:24:14,602 I'M LIZ NIELSEN, DIRECTOR OF THE 657 00:24:14,602 --> 00:24:15,136 DIVISION. 658 00:24:15,136 --> 00:24:17,772 SO I'M PLEASED TO WELCOME 659 00:24:17,772 --> 00:24:19,240 LONG-TIME GRANDY BEN CHAPMAN, 660 00:24:19,240 --> 00:24:22,143 WHO JOINED BSR EARLIER THIS 661 00:24:22,143 --> 00:24:24,212 MONTH AS THE CHIEF OF OUR 662 00:24:24,212 --> 00:24:25,313 INDIVIDUAL BEHAVIORAL PROCESSES 663 00:24:25,313 --> 00:24:29,984 BRANCH, WHERE HE'S SUCCEEDED DRY 664 00:24:29,984 --> 00:24:31,486 DIRECTOR OF OBSSR. 665 00:24:31,486 --> 00:24:32,954 BEN JOINS US FROM THE UNIVERSITY 666 00:24:32,954 --> 00:24:33,788 OF ROCHESTER MEDICAL CENTER 667 00:24:33,788 --> 00:24:35,623 WHERE HE WAS A FULL PROFESSOR AT 668 00:24:35,623 --> 00:24:39,694 P.I. OF R01s, R2 #s AND R61, 669 00:24:39,694 --> 00:24:42,530 ALL STARTING WITH AN NIIK AWARD 670 00:24:42,530 --> 00:24:43,264 BACK IN 2008. 671 00:24:43,264 --> 00:24:47,435 HE HAS A PH.D. IN PSYCHOLOGY AND 672 00:24:47,435 --> 00:24:49,003 M.P.H. AND MS IN BIOSTATISTICS 673 00:24:49,003 --> 00:24:49,971 FROM ROCHESTER. 674 00:24:49,971 --> 00:24:51,406 THE THEMES IN HIS WORK HAVE BEEN 675 00:24:51,406 --> 00:24:53,474 THE INTERFACE OF PERSONALITY AND 676 00:24:53,474 --> 00:24:55,009 SOCIAL CLASS AS THEY PERTAIN TO 677 00:24:55,009 --> 00:24:56,544 LATER LIFE MORTALITY AND 678 00:24:56,544 --> 00:24:58,713 COGNITIVE OUTCOMES, MINDFULNESS 679 00:24:58,713 --> 00:25:00,348 AND SOCIAL ISOLATION AMONG OLDER 680 00:25:00,348 --> 00:25:01,783 ADULTS AND MOST RECENTLY THE 681 00:25:01,783 --> 00:25:03,551 LINKS BETWEEN BILINGUALISM 682 00:25:03,551 --> 00:25:04,519 PERCEIVED DISCRIMINATION AND 683 00:25:04,519 --> 00:25:06,287 LATER LIFE COGNITIVE OUTCOMES. 684 00:25:06,287 --> 00:25:08,556 BEN WAS ALSO A MEMBER OF THE 685 00:25:08,556 --> 00:25:09,757 SOCIAL PERSONALITY AND 686 00:25:09,757 --> 00:25:13,161 INTERPERSONAL PROCESSES OR SPIP 687 00:25:13,161 --> 00:25:15,129 STUDY SECTION IN CSR AND SERVED 688 00:25:15,129 --> 00:25:17,532 ON NUMEROUS NIA SPECIAL EMPHASIS 689 00:25:17,532 --> 00:25:18,366 PANELS. 690 00:25:18,366 --> 00:25:20,368 HE WAS ASSOCIATE EDITOR OF 691 00:25:20,368 --> 00:25:22,670 PSYCHOSOMATIC MEDICINE AND LONG 692 00:25:22,670 --> 00:25:23,771 TIME EDITORIAL BOARD MEMBER OF 693 00:25:23,771 --> 00:25:25,073 PSYCHOLOGY AND AGING AND WE'RE 694 00:25:25,073 --> 00:25:27,275 REALLY THRILLED TO HAVE BEN JOIN 695 00:25:27,275 --> 00:25:28,376 US IN BSR. 696 00:25:28,376 --> 00:25:30,445 BEN IS HERE, CAN GIVE A WAVE FOR 697 00:25:30,445 --> 00:25:34,816 THOSE IN THE ROOM. 698 00:25:34,816 --> 00:25:38,853 WE'RE ALSO HAPPY TO WELCOME 699 00:25:38,853 --> 00:25:41,389 ASHLY SNEED TO FILL URGENT NEEDS 700 00:25:41,389 --> 00:25:42,957 FOR MORE CENTRAL ADMINISTRATIVE 701 00:25:42,957 --> 00:25:43,357 SUPPORT. 702 00:25:43,357 --> 00:25:45,760 SHE'S WORKING ON TRAVEL AND 703 00:25:45,760 --> 00:25:48,696 CONFERENCE REGISTRATIONS FOR 704 00:25:48,696 --> 00:25:50,998 STAFF AND IS ATTENDING DOMESTIC 705 00:25:50,998 --> 00:25:51,666 TRAVEL TRAINING. 706 00:25:51,666 --> 00:25:53,835 SHE'LL BE HANDLING ANNUM BER OF 707 00:25:53,835 --> 00:25:54,736 OTHER PURCHASING REQUIREMENTS AS 708 00:25:54,736 --> 00:25:55,269 WELL. 709 00:25:55,269 --> 00:25:56,604 SHE'S COMING WITH ADMINISTRATIVE 710 00:25:56,604 --> 00:25:58,306 OPERATIONS AND CUSTOMER SERVICE 711 00:25:58,306 --> 00:25:59,874 EXPERIENCE FROM MEDSTAR 712 00:25:59,874 --> 00:26:00,675 GEORGETOWN UNIVERSITY HOSPITAL 713 00:26:00,675 --> 00:26:01,843 AND CHILDREN'S NATIONAL 714 00:26:01,843 --> 00:26:02,343 HOSPITAL, BOTH IN 715 00:26:02,343 --> 00:26:04,579 WASHINGTON, D.C. 716 00:26:04,579 --> 00:26:06,848 IN JULY, WE WELCOMED TWO NEW 717 00:26:06,848 --> 00:26:09,350 STAFF MEMBERS IN BSR'S OFFICE OF 718 00:26:09,350 --> 00:26:11,786 DATA RESOURCES AND ANALYTICS OR 719 00:26:11,786 --> 00:26:12,653 ODRA. 720 00:26:12,653 --> 00:26:15,957 JOSEPH CHIARENZELLI JOINED AS A 721 00:26:15,957 --> 00:26:17,258 SOCIAL SCIENCE ANALYST TO 722 00:26:17,258 --> 00:26:18,392 COORDINATE STRATEGIC PLANNING 723 00:26:18,392 --> 00:26:20,428 AND OPERATIONS AND TO OVERSEE 724 00:26:20,428 --> 00:26:20,862 PROJECT MANAGEMENT. 725 00:26:20,862 --> 00:26:22,930 HE COMES TO US FROM THE DHHS 726 00:26:22,930 --> 00:26:25,099 OFFICE OF INSPECTOR GENERAL OR 727 00:26:25,099 --> 00:26:27,034 OIG, WHERE HE PROVIDED STRATEGIC 728 00:26:27,034 --> 00:26:29,170 PLANNING AND POLICY SUPPORT TO 729 00:26:29,170 --> 00:26:30,805 OIG LEADERSHIP, MANAGED A BROAD 730 00:26:30,805 --> 00:26:33,007 PORTFOLIO OF PROGRAM EVALUATIONS 731 00:26:33,007 --> 00:26:35,409 ACROSS HHS FOCUSED ON SCIENTIFIC 732 00:26:35,409 --> 00:26:37,278 INTEGRITY, MEDICARE, AND 733 00:26:37,278 --> 00:26:39,147 TECHNOLOGY, AND DESIGNED AND 734 00:26:39,147 --> 00:26:40,248 IMPLEMENTED POLICIES, PROCEDURES 735 00:26:40,248 --> 00:26:41,115 AND DATA SYSTEMS. 736 00:26:41,115 --> 00:26:43,684 HE HAS AN M.P.H. DEGREE FROM THE 737 00:26:43,684 --> 00:26:44,819 UNIVERSITY OF ALBANY BEFORE 738 00:26:44,819 --> 00:26:45,887 JOINING THE FEDERAL GOVERNMENT 739 00:26:45,887 --> 00:26:47,021 AS A PRESIDENTIAL MANAGEMENT 740 00:26:47,021 --> 00:26:48,856 FELLOW. 741 00:26:48,856 --> 00:26:53,261 AND DR. ESMERALDA RAMIREZ-PENA 742 00:26:53,261 --> 00:26:54,562 IS WORKING ON INITIATIVES 743 00:26:54,562 --> 00:26:56,297 RELATED TO REAL WORLD DATA AND 744 00:26:56,297 --> 00:26:57,231 ADVANCED ANALYTICS. 745 00:26:57,231 --> 00:26:59,167 SHE JOINS US FROM THE NATIONAL 746 00:26:59,167 --> 00:26:59,801 CANCER INSTITUTE, WHERE SHE 747 00:26:59,801 --> 00:27:02,436 WORKED WITH THE SEER PROGRAM TO 748 00:27:02,436 --> 00:27:03,971 DEVELOP METHODS FOR THE QUALITY 749 00:27:03,971 --> 00:27:05,506 ASSESSMENT OF THE REGISTRY'S 750 00:27:05,506 --> 00:27:07,008 FIRST COLLECTION OF CANCER 751 00:27:07,008 --> 00:27:08,242 RECURRENCE DATA FROM ELECTRONIC 752 00:27:08,242 --> 00:27:10,211 HEALTH RECORDS, AND ITS LINKAGE 753 00:27:10,211 --> 00:27:11,712 TO PHARMACY CLAIMS. 754 00:27:11,712 --> 00:27:13,915 SHE HOLDS A PH.D. IN BIOMEDICAL 755 00:27:13,915 --> 00:27:15,349 SCIENCES FROM THE UNIVERSITY OF 756 00:27:15,349 --> 00:27:17,218 TEXAS MD ANDERSON CANCER CENTER, 757 00:27:17,218 --> 00:27:23,658 PGH >> TRUAND AN M.P.H. 758 00:27:23,658 --> 00:27:26,494 IN JUNE JONATHAN GOOCH JOINED 759 00:27:26,494 --> 00:27:27,929 THE CLINICAL TRIALS OFFICE AS A 760 00:27:27,929 --> 00:27:28,796 CLINICAL TRIALS COORDINATOR, 761 00:27:28,796 --> 00:27:30,198 WHERE HE IS PROVIDING DATA AND 762 00:27:30,198 --> 00:27:34,035 SAFETY MONITORING BOARD OR DSMB 763 00:27:34,035 --> 00:27:35,369 SUPPORT, CUSTOMER SUPPORT AND 764 00:27:35,369 --> 00:27:37,104 CLINICAL TRY TRIAL SUPPORT 765 00:27:37,104 --> 00:27:38,206 ACROSS THE PORTFOLIO AREAS. 766 00:27:38,206 --> 00:27:39,407 JONATHAN JOINS US AFTER WORKING 767 00:27:39,407 --> 00:27:41,042 AS A SENIOR CLINICAL TRIAL 768 00:27:41,042 --> 00:27:43,444 PROJECT MANAGER FOR A CONTRACT 769 00:27:43,444 --> 00:27:44,745 RESEARCH ORGANIZATION, WHERE HE 770 00:27:44,745 --> 00:27:45,980 MANAGED CONTRACT THAT PROVIDES 771 00:27:45,980 --> 00:27:48,349 CLINICAL STUDIES MANAGEMENT AND 772 00:27:48,349 --> 00:27:50,551 SUPPORT ACROSS NIA'S EXTRAMURAL 773 00:27:50,551 --> 00:27:51,853 DIVISIONS. 774 00:27:51,853 --> 00:27:53,988 AND FINALLY, WE HAVE TWO NEW 775 00:27:53,988 --> 00:27:55,590 PROGRAM OFFICIALS IN OUR 776 00:27:55,590 --> 00:27:57,325 POPULATION AND SOCIAL PROCESSES 777 00:27:57,325 --> 00:27:58,659 BRANCH OUR PSP. 778 00:27:58,659 --> 00:28:02,597 FIRST DR. LEWE DUAN JOINS US IN 779 00:28:02,597 --> 00:28:03,564 JULY FROM THE CENTER FOR 780 00:28:03,564 --> 00:28:05,166 MEDICARE AND MEDICAID SERVICES 781 00:28:05,166 --> 00:28:06,634 WHERE SHE OVERSAW COMPREHENSIVE 782 00:28:06,634 --> 00:28:08,936 REVIEWS OF POLICY IMPACTS ON 783 00:28:08,936 --> 00:28:09,904 HEALTH SYSTEMS AND OUTCOMES. 784 00:28:09,904 --> 00:28:12,006 AS A PROGRAM OFFICER IN BSR, 785 00:28:12,006 --> 00:28:13,307 SHE'S ADVANCING OUR HEALTH 786 00:28:13,307 --> 00:28:14,842 SYSTEMS RESEARCH PORTFOLIO 787 00:28:14,842 --> 00:28:17,345 FOCUSING ON DEMENTIA CARE 788 00:28:17,345 --> 00:28:18,346 TRIALS, BEHAVIORAL ECONOMICS AND 789 00:28:18,346 --> 00:28:21,282 HEALTHCARE AND PALLIATIVE CARE. 790 00:28:21,282 --> 00:28:24,218 SHE HOLDS A PH.D. IN ECONOMICS 791 00:28:24,218 --> 00:28:25,453 FROM THE UNIVERSITY OF SOUTHERN 792 00:28:25,453 --> 00:28:26,420 CALIFORNIA AND A MASTER'S IN 793 00:28:26,420 --> 00:28:28,189 BIOLOGY WITH A FOCUS ON 794 00:28:28,189 --> 00:28:30,191 MOLECULAR GENETICS FROM UNC 795 00:28:30,191 --> 00:28:30,591 CHAPEL HILL. 796 00:28:30,591 --> 00:28:32,126 PRIOR TO JOINING THE FEDERAL 797 00:28:32,126 --> 00:28:35,296 GOVERNMENT, SHE CONDUCTED 798 00:28:35,296 --> 00:28:37,164 RESEARCH AT KAISER MERM NEN TAI 799 00:28:37,164 --> 00:28:40,868 AND WAS A PRINCIPAL 800 00:28:40,868 --> 00:28:41,302 STATISTICIAN. 801 00:28:41,302 --> 00:28:45,907 LAST BUT NOT LEAST DR. YUNA 802 00:28:45,907 --> 00:28:47,208 BAE-SHAAW JOINED IN MID AUGUST 803 00:28:47,208 --> 00:28:48,843 AND IS ALSO ADVANCING OUR HEALTH 804 00:28:48,843 --> 00:28:49,477 SYSTEMS PORTFOLIO. 805 00:28:49,477 --> 00:28:51,312 SHE IS FOCUSING ON RESEARCH ON 806 00:28:51,312 --> 00:28:53,114 MEDICARE ADVANTAGE AND PART D, 807 00:28:53,114 --> 00:28:55,716 DRUG DISCOVERY AND ACCESS AND 808 00:28:55,716 --> 00:28:56,250 LONG-TERM CARE FINANCING. 809 00:28:56,250 --> 00:28:58,920 PRIOR TO JOINING NIA, SHE WAS A 810 00:28:58,920 --> 00:28:59,787 RESEARCH ASSISTANT PROFESSOR AT 811 00:28:59,787 --> 00:29:02,189 THE UNIVERSITY OF SOUTHERN 812 00:29:02,189 --> 00:29:03,958 CALIFORNIA MANN SCHOOL OF 813 00:29:03,958 --> 00:29:05,126 PHARMACY, WHERE HER RESEARCH 814 00:29:05,126 --> 00:29:06,661 FOCUSED ON INTERVENTIONS AND 815 00:29:06,661 --> 00:29:08,596 POLICIES AIMED AT IMPROVING 816 00:29:08,596 --> 00:29:09,964 DEMENTIA CARE IN NURSING HOMES 817 00:29:09,964 --> 00:29:14,568 AND ON IMPACT EVALUATIONS OF 818 00:29:14,568 --> 00:29:15,436 VALUE-BASED MULTIDISCIPLINARY 819 00:29:15,436 --> 00:29:16,837 CARE DELIVERY MODELS FOR 820 00:29:16,837 --> 00:29:19,140 MANAGING POORLY CONTROLLED 821 00:29:19,140 --> 00:29:22,743 CHRONIC CONDITIONS. 822 00:29:22,743 --> 00:29:24,178 SO PLEASE JOIN ME IN WELCOMING 823 00:29:24,178 --> 00:29:25,913 ALL THESE TERRIFIC NEW STAFF TO 824 00:29:25,913 --> 00:29:26,080 BSR. 825 00:29:26,080 --> 00:29:31,752 THANK YOU. 826 00:29:31,752 --> 00:29:33,821 >> HI. 827 00:29:33,821 --> 00:29:35,122 OUR DIVISION WOULD LIKE TO 828 00:29:35,122 --> 00:29:38,092 WELCOME MONICA SERRA, WHO JOINS 829 00:29:38,092 --> 00:29:41,896 US IN ONE OF THE PEPPER CENTERS 830 00:29:41,896 --> 00:29:43,531 IN OUR GERIATRICS BRANCH. 831 00:29:43,531 --> 00:29:50,338 SHE'LL BE WORKING ON OUR MUST 832 00:29:50,338 --> 00:29:51,105 MUSCULOSKELETAL PORTFOLIOS, AND 833 00:29:51,105 --> 00:29:53,374 ALSO ON RESILIENCE. 834 00:29:53,374 --> 00:29:56,877 AND CHRISTIAN HATCHER IS A 835 00:29:56,877 --> 00:29:58,946 HEALTH SPECIALIST JOINING OUR 836 00:29:58,946 --> 00:30:00,381 ADMINISTRATIVE UNIT, AND HE'S 837 00:30:00,381 --> 00:30:03,017 GOT A STRONG BACKGROUND BOTH IN 838 00:30:03,017 --> 00:30:04,552 SCIENCE AND ADMINISTRATION AND 839 00:30:04,552 --> 00:30:06,287 WILL BE WORKING ON COORDINATING 840 00:30:06,287 --> 00:30:06,921 ADMINISTRATIVE ACTIVITIES WITH 841 00:30:06,921 --> 00:30:09,623 THE VARIOUS SCIENTIFIC INQUIRIES 842 00:30:09,623 --> 00:30:11,092 AND ACTIVITIES OF THE DIVISION 843 00:30:11,092 --> 00:30:13,527 AND THE INTERFACE WITH THE REST 844 00:30:13,527 --> 00:30:14,929 OF NIA AND NIH. 845 00:30:14,929 --> 00:30:16,564 SO PLEASE JOIN US IN WELCOMING 846 00:30:16,564 --> 00:30:16,998 THEM. 847 00:30:16,998 --> 00:30:18,866 I THINK MONICA MAY BE HERE? 848 00:30:18,866 --> 00:30:22,603 I THINK CHRISTIAN IS AWAY. 849 00:30:22,603 --> 00:30:23,671 SHE MAY BE ELSEWHERE TOO. 850 00:30:23,671 --> 00:30:28,275 THANK YOU. 851 00:30:28,275 --> 00:30:29,944 >> GOOD MORNING. 852 00:30:29,944 --> 00:30:32,346 I'M DELIGHTED TO ANNOUNCE AND 853 00:30:32,346 --> 00:30:34,048 WELCOME SOME NEW MEMBERS TO THE 854 00:30:34,048 --> 00:30:36,617 DIVISION OF NEUROSCIENCE. 855 00:30:36,617 --> 00:30:39,553 FIRST MIKE GREENE, HE'S JOINING 856 00:30:39,553 --> 00:30:42,790 US AS AN NIH PATHWAYS FELLOW IN 857 00:30:42,790 --> 00:30:44,158 THE DIVISION OF NEUROSCIENCE. 858 00:30:44,158 --> 00:30:46,427 WHERE HE'S GOING TO BE -- OR 859 00:30:46,427 --> 00:30:50,398 HE'S WORKING WITH RICHARD QUACK 860 00:30:50,398 --> 00:30:52,900 AND EMERALD AND THE TEAM ON THE 861 00:30:52,900 --> 00:30:55,403 NIA CLIMATE ON INTEGRATED DATA 862 00:30:55,403 --> 00:31:00,007 ON CLIMATE CHANGE TO THE 863 00:31:00,007 --> 00:31:03,177 EXPOSOME STUDIES THAT THE 864 00:31:03,177 --> 00:31:05,246 DIVISIONS, BOTH BS R AND D N AND 865 00:31:05,246 --> 00:31:07,348 OTHERS ARE CONDUCTING. 866 00:31:07,348 --> 00:31:09,250 HE'S CURRENTLY A JUNIOR AT 867 00:31:09,250 --> 00:31:11,385 BOSTON UNIVERSITY, WHERE HE 868 00:31:11,385 --> 00:31:12,353 STUDIES COMPUTER SCIENCE AND 869 00:31:12,353 --> 00:31:14,889 INTERNATIONAL RELATIONS, AND HE 870 00:31:14,889 --> 00:31:16,690 ALSO HAS EXPERIENCE AT OTHER NI 871 00:31:16,690 --> 00:31:23,097 IHINS TE 872 00:31:23,097 --> 00:31:24,932 INSTITUTES LIKE NIAID WHERE HE 873 00:31:24,932 --> 00:31:26,467 WAS WORKING ON SOLUTIONS FOR 874 00:31:26,467 --> 00:31:28,436 PRECISE SOFTWARE FUNCTIONING. 875 00:31:28,436 --> 00:31:33,274 AND HE HAS WIDE EXPERIENCE IN 876 00:31:33,274 --> 00:31:35,709 COMPUTER AND DATA MANAGEMENT, SO 877 00:31:35,709 --> 00:31:37,545 HE'S A GREAT ADDITION TO THE 878 00:31:37,545 --> 00:31:37,845 TEAM. 879 00:31:37,845 --> 00:31:41,449 NEXT WE HAVE JANE HETTINGER, AND 880 00:31:41,449 --> 00:31:44,085 SHE'S JOINING THE DIVISION AS A 881 00:31:44,085 --> 00:31:46,287 PROGRAM DIRECTOR AND BRANCH OF 882 00:31:46,287 --> 00:31:48,222 CLINICAL INTERVENTIONS AND 883 00:31:48,222 --> 00:31:50,858 DIAGNOSTICS, WHERE SHE'S 884 00:31:50,858 --> 00:31:54,261 MANAGING THE PORTFOLIOS ON 885 00:31:54,261 --> 00:31:56,564 ADDrd NON-PHARMACOLOGICAL 886 00:31:56,564 --> 00:32:00,267 CLINICAL TRIALS TOGETHER WITH 887 00:32:00,267 --> 00:32:01,602 CHRISTINA AND LAURIE AND SHE'S 888 00:32:01,602 --> 00:32:05,039 ALSO SUPPORTING A NUMBER OF 889 00:32:05,039 --> 00:32:10,711 OTHER INTERVENTIONS RELATED TO 890 00:32:10,711 --> 00:32:12,146 LIFESTYLE AND DELAYING DEMENTIA. 891 00:32:12,146 --> 00:32:16,183 SHE'S ALSO INVOLVED IN COGNITIVE 892 00:32:16,183 --> 00:32:21,088 TRAINING, SLEEP TRIAL MANAGEMENT 893 00:32:21,088 --> 00:32:27,661 AND OTHER PREVENTION AND 894 00:32:27,661 --> 00:32:28,529 TREATING DEMENTIA. 895 00:32:28,529 --> 00:32:30,064 JANE ALSO HAS EXPERIENCE AT NIH, 896 00:32:30,064 --> 00:32:33,901 SHE WAS PREVIOUSLY AT NCI IN 897 00:32:33,901 --> 00:32:36,103 THE -- AS PROGRAM DIRECTOR IN 898 00:32:36,103 --> 00:32:37,505 THE CENTERS FOR COORDINATING 899 00:32:37,505 --> 00:32:38,939 CLINICAL TRIALS, AND SHE WAS 900 00:32:38,939 --> 00:32:41,575 ALSO AT NINDS, WHERE SHE WAS 901 00:32:41,575 --> 00:32:44,078 PART OF THE NEUROBIOBANK AND THE 902 00:32:44,078 --> 00:32:46,480 ALS STRATEGIC PLAN. 903 00:32:46,480 --> 00:32:48,782 SHE RECEIVED HER PH.D. IN 904 00:32:48,782 --> 00:32:51,285 NEUROSCIENCES FROM WASHINGTON 905 00:32:51,285 --> 00:32:52,720 UNIVERSITY, AND ALSO COMPLETED 906 00:32:52,720 --> 00:32:59,760 THE POSTDOCTORAL TRAINING IN THE 907 00:32:59,760 --> 00:33:00,728 MAXIMILIAN'S UNIVERSITY IN 908 00:33:00,728 --> 00:33:02,596 MUNICH, AND SHE DID RESEARCH AT 909 00:33:02,596 --> 00:33:05,633 THAT TIME IN MICROGLIA AND 910 00:33:05,633 --> 00:33:09,570 ALZHEIMER'S DISEASE. 911 00:33:09,570 --> 00:33:12,540 EVA LAW SON-LIPCHIN, SHE 912 00:33:12,540 --> 00:33:14,708 ACTUALLY WAS SEVERAL YEARS AGO 913 00:33:14,708 --> 00:33:17,244 MEMBER OF DN, ABOUT SEVEN, EIGHT 914 00:33:17,244 --> 00:33:21,282 YEARS AGO, AND THEN SHE WENT TO 915 00:33:21,282 --> 00:33:23,017 WORK FOR THE DIVISION OF 916 00:33:23,017 --> 00:33:25,119 EXTRAMURAL AFFAIRS, WHERE SHE 917 00:33:25,119 --> 00:33:28,289 WAS THERE FOR A FEW YEARS AND 918 00:33:28,289 --> 00:33:29,356 THEN WITH DELOITTE AND MORE 919 00:33:29,356 --> 00:33:36,397 RECENTLY, SHE WAS WORKING WITH 920 00:33:36,397 --> 00:33:37,531 HEVOLUTION, A NON-PROFIT 921 00:33:37,531 --> 00:33:38,599 ORGANIZATION FUNDING AGING 922 00:33:38,599 --> 00:33:41,068 RESEARCH, AND SHE JUST REJOINED 923 00:33:41,068 --> 00:33:42,937 NIA RECENTLY IN THE OFFICE OF 924 00:33:42,937 --> 00:33:45,873 STRATEGIC DEVELOPMENT AND 925 00:33:45,873 --> 00:33:47,308 PARTNERSHIPS IN THE DIVISION OF 926 00:33:47,308 --> 00:33:48,175 NEUROSCIENCE AS A PROGRAM 927 00:33:48,175 --> 00:33:51,345 ANALYST, WHERE SHE'S OVERSEEING 928 00:33:51,345 --> 00:33:54,081 AND MANAGING THE INTERNATIONAL 929 00:33:54,081 --> 00:33:55,950 ALZHEIMER'S AND RELATED 930 00:33:55,950 --> 00:33:58,886 DEMENTIAS RESEARCH PORTFOLIO OR 931 00:33:58,886 --> 00:33:59,486 IADRP. 932 00:33:59,486 --> 00:34:02,389 SHE HAS EXTENSIVE EXPERIENCE IN 933 00:34:02,389 --> 00:34:06,126 GRANTS MANAGEMENT, PROJECT 934 00:34:06,126 --> 00:34:07,962 MANAGEMENT AND OTHER 935 00:34:07,962 --> 00:34:09,296 ADMINISTRATIVE ISSUES, SO WE'RE 936 00:34:09,296 --> 00:34:10,598 DELIGHTED FOR HER ALSO. 937 00:34:10,598 --> 00:34:12,700 SO JOIN ME ON WELCOMING THEM TO 938 00:34:12,700 --> 00:34:13,100 THE INSTITUTE. 939 00:34:13,100 --> 00:34:20,808 THANK YOU. 940 00:34:20,808 --> 00:34:24,178 >> NEXT UP IT'S MY PLEASURE TO 941 00:34:24,178 --> 00:34:24,945 ANNOUNCE THREE NEW STAFF MEMBERS 942 00:34:24,945 --> 00:34:26,680 TO THE DIVISION OF EXTRAMURAL 943 00:34:26,680 --> 00:34:28,115 ACTIVITIES. 944 00:34:28,115 --> 00:34:32,386 FIRST UP IS MAYRA ALVAREZ LOPEZ, 945 00:34:32,386 --> 00:34:35,155 AND SHE IS A PROGRAM ANALYST IN 946 00:34:35,155 --> 00:34:36,657 THE OFFICE OF STRATEGIC 947 00:34:36,657 --> 00:34:39,026 EXTRAMURAL PROGRAMS, WHERE SHE 948 00:34:39,026 --> 00:34:40,894 SUPPORTS A WIDE RANGE OF PROGRAM 949 00:34:40,894 --> 00:34:46,367 ACTIVITIES AND INITIATIVES FOR 950 00:34:46,367 --> 00:34:47,468 OCEP'S SMALL BUSINESS INNOVATION 951 00:34:47,468 --> 00:34:48,902 RESEARCH AND SMALL BUSINESS 952 00:34:48,902 --> 00:34:49,670 TECHNOLOGY TRANSFER PROGRAMS. 953 00:34:49,670 --> 00:34:54,475 PRIOR TO JOINING NIA, MAYRA 954 00:34:54,475 --> 00:34:56,777 SERVED AS A PROGRAM ANALYST AT 955 00:34:56,777 --> 00:34:57,845 THE NATIONAL CENTER FOR 956 00:34:57,845 --> 00:34:59,747 ADVANCING TRANSLATIONAL 957 00:34:59,747 --> 00:35:01,715 SCIENCES, NCATS, IN THE OFFICE 958 00:35:01,715 --> 00:35:04,184 OF STRATEGIC ALLIANCE. 959 00:35:04,184 --> 00:35:05,953 SHE CONDUCTED OUTREACH 960 00:35:05,953 --> 00:35:07,254 COMMUNICATION ACTIVITIES AND 961 00:35:07,254 --> 00:35:09,123 MANAGEMENT OF GRANT 962 00:35:09,123 --> 00:35:09,890 APPLICATIONS, CONTRACTS AND 963 00:35:09,890 --> 00:35:13,294 TECHNICAL ASSISTANCE GRANTS 964 00:35:13,294 --> 00:35:15,896 AWARDED TO SMALL BUSINESSES, AND 965 00:35:15,896 --> 00:35:17,998 FINALLY, SHE RECEIVED HER 966 00:35:17,998 --> 00:35:19,199 BACHELOR'S DEGREE IN GOVERNMENT 967 00:35:19,199 --> 00:35:21,268 AND INTERNATIONAL POLITICS WITH 968 00:35:21,268 --> 00:35:23,237 A CONCENTRATION ON INTERNATIONAL 969 00:35:23,237 --> 00:35:24,772 POLICY AND HER MASTER'S DEGREE 970 00:35:24,772 --> 00:35:26,607 IN ORGANIZATIONAL DEVELOPMENT 971 00:35:26,607 --> 00:35:28,776 AND KNOWLEDGE MANAGEMENT AT 972 00:35:28,776 --> 00:35:32,313 GEORGE MASON UNIVERSITY IN 973 00:35:32,313 --> 00:35:34,615 ARLINGTON. 974 00:35:34,615 --> 00:35:38,485 NEXT IS KELLI OSTER. 975 00:35:38,485 --> 00:35:42,823 KELLI JOINED NIA AS A GRANTS 976 00:35:42,823 --> 00:35:44,992 MANAGEMENT SPECIALIST IN 1990 977 00:35:44,992 --> 00:35:47,428 AND HAS SERVED IN GRANTS 978 00:35:47,428 --> 00:35:48,962 MANAGEMENT AT THE NATIONAL 979 00:35:48,962 --> 00:35:50,831 CANCER INSTITUTE AND THE NURSING 980 00:35:50,831 --> 00:35:52,900 INSTITUTE, BOTH AS TEAM LEADER 981 00:35:52,900 --> 00:35:55,102 AND SPECIALIST. 982 00:35:55,102 --> 00:36:00,507 SHE JOINED -- SHE HAS HER B.S. 983 00:36:00,507 --> 00:36:02,109 DEGREE IN LONG TERM HEALTHCARE 984 00:36:02,109 --> 00:36:03,077 ADMINISTRATION AND BUSINESS 985 00:36:03,077 --> 00:36:09,116 ADMINISTRATION FROM SOUTHERN 986 00:36:09,116 --> 00:36:09,550 AVENTUS UNIVERSITY. 987 00:36:09,550 --> 00:36:13,487 NEXT IS DR. CATRINA ROBINSON. 988 00:36:13,487 --> 00:36:14,588 DR. ROBINSON IS A SCIENTIFIC 989 00:36:14,588 --> 00:36:15,989 REVIEW OFFICER IN THE SCIENTIFIC 990 00:36:15,989 --> 00:36:16,423 REVIEW BRANCH. 991 00:36:16,423 --> 00:36:20,461 SHE EARNED A PH.D. IN 992 00:36:20,461 --> 00:36:22,429 PHARMACOLOGY FROM AUBURN 993 00:36:22,429 --> 00:36:23,664 UNIVERSITY AND COMPLETED A 994 00:36:23,664 --> 00:36:24,832 POSTDOC FELLOWSHIP AT THE 995 00:36:24,832 --> 00:36:26,266 UNIVERSITY OF MICHIGAN. 996 00:36:26,266 --> 00:36:27,801 RECENTLY SHE WAS AN ASSOCIATE 997 00:36:27,801 --> 00:36:29,636 PROFESSOR IN THE DEPARTMENT OF 998 00:36:29,636 --> 00:36:31,105 NEUROLOGY AT THE MEDICAL 999 00:36:31,105 --> 00:36:33,273 UNIVERSITY OF SOUTH CAROLINA AND 1000 00:36:33,273 --> 00:36:35,576 RESEARCH HEALTH SCIENTIST AT THE 1001 00:36:35,576 --> 00:36:38,746 RALPH JOHNSON VA MEDICAL CENTER. 1002 00:36:38,746 --> 00:36:43,984 CATRI IN TNA'S RESEARCH FOCUSEDN 1003 00:36:43,984 --> 00:36:45,419 UNDERSTANDING THE IMPACT OF 1004 00:36:45,419 --> 00:36:48,355 METABOLIC RISK FACTORS SUCH AS 1005 00:36:48,355 --> 00:36:49,790 DIABETES, OBESITY, INSULIN 1006 00:36:49,790 --> 00:36:50,858 RESISTANCE AND HIGH CHOLESTEROL 1007 00:36:50,858 --> 00:36:53,060 ON COGNITIVE AGING AND DEMENTIA. 1008 00:36:53,060 --> 00:36:54,495 SO PLEASE WELCOME OUR THREE NEW 1009 00:36:54,495 --> 00:36:55,262 MEMBERS TO DEA. 1010 00:36:55,262 --> 00:36:57,664 THANK YOU. 1011 00:36:57,664 --> 00:37:01,068 >> GOOD MORNING, I'M PATRICK 1012 00:37:01,068 --> 00:37:01,935 SHIRDON, EXECUTIVE OFFICER FOR 1013 00:37:01,935 --> 00:37:02,369 NIA. 1014 00:37:02,369 --> 00:37:04,571 WE HAVE SOME NEW MEMBERS TO OUR 1015 00:37:04,571 --> 00:37:06,306 TEAM WE'RE EXCITED TO HAVE. 1016 00:37:06,306 --> 00:37:09,143 MARIE RAPOPORT COMES TO US FROM 1017 00:37:09,143 --> 00:37:10,778 THE UNIVERSITY OF NORTH CAROLINA 1018 00:37:10,778 --> 00:37:11,678 AT CHARLOTTE AND SHE'S GOING TO 1019 00:37:11,678 --> 00:37:13,547 BE WORKING ON ALL THE THINGS TO 1020 00:37:13,547 --> 00:37:15,516 HELP US DEAL WITH OUR DAILY 1021 00:37:15,516 --> 00:37:17,017 OPERATIONAL PROCESSES AND 1022 00:37:17,017 --> 00:37:18,118 FINANCES, SO EXCITED TO HAVE 1023 00:37:18,118 --> 00:37:21,188 HER. 1024 00:37:21,188 --> 00:37:22,823 WE'RE ALSO EXCITED TO HAVE INTO 1025 00:37:22,823 --> 00:37:26,560 OUR IT OR TECHNOLOGY BRANCH 1026 00:37:26,560 --> 00:37:29,163 JANET CHOI, WITH US CURRENTLY AS 1027 00:37:29,163 --> 00:37:30,697 A MEMBER OF THE UNIVERSITY OF 1028 00:37:30,697 --> 00:37:32,065 MARYLAND MAJORING IN COMPUTER 1029 00:37:32,065 --> 00:37:34,535 SCIENCE AND SHE'LL BE A PART OF 1030 00:37:34,535 --> 00:37:36,403 OUR EMERGING TECHNOLOGY GROUP. 1031 00:37:36,403 --> 00:37:39,907 ELY YONCE, COMPUTER SCIENCE 1032 00:37:39,907 --> 00:37:41,542 MAJOR, AGAIN IN OUR EMERGING 1033 00:37:41,542 --> 00:37:43,377 TECHNOLOGY GROUP FOCUSING ON 1034 00:37:43,377 --> 00:37:45,045 SOME OF THE OPPORTUNITIES TO 1035 00:37:45,045 --> 00:37:46,246 CREATE EFFICIENCIES WITH 1036 00:37:46,246 --> 00:37:47,448 ARTIFICIAL INTELLIGENCE ON THE 1037 00:37:47,448 --> 00:37:52,686 OPERATIONS SIDE. 1038 00:37:52,686 --> 00:37:54,321 SO IN OUR WORKFORCE AND 1039 00:37:54,321 --> 00:37:55,122 ADMINISTRATIVE MANAGEMENT 1040 00:37:55,122 --> 00:37:57,291 BRANCH, WE HAVE A FEW NEW FOLKS 1041 00:37:57,291 --> 00:37:59,159 THAT WE COULDN'T BE MORE PLEASED 1042 00:37:59,159 --> 00:38:00,360 TO HAVE. 1043 00:38:00,360 --> 00:38:06,900 JOSE GALLEGOS COMES FROM THE 1044 00:38:06,900 --> 00:38:12,039 BARBARNES CENTER FOR ENLISTED 1045 00:38:12,039 --> 00:38:14,908 EDUCATION AT MAXWELL AIR FORCE 1046 00:38:14,908 --> 00:38:16,210 BASE GOING TO BE WORKING WITH US 1047 00:38:16,210 --> 00:38:17,110 TO INTEGRATE TECHNOLOGY AND THE 1048 00:38:17,110 --> 00:38:18,612 WAYS IN WHICH WE ONBOARD AND 1049 00:38:18,612 --> 00:38:20,280 DEAL WITH HUMAN CAPITAL. 1050 00:38:20,280 --> 00:38:24,418 JOY DE LOS SANTOS, IN TERMS OF 1051 00:38:24,418 --> 00:38:25,419 COORDINATION FOR OUR FURLOUGHS 1052 00:38:25,419 --> 00:38:28,789 AND PERSONNEL PLANNING DISASTER 1053 00:38:28,789 --> 00:38:29,556 RECOVERY TYPE ACTIVITIES. 1054 00:38:29,556 --> 00:38:30,557 VERY EXCITED TO HAVE THEM JOIN 1055 00:38:30,557 --> 00:38:33,594 THE TEAM. 1056 00:38:33,594 --> 00:38:37,531 WE ALSO HAVE JACK ALPERT, 1057 00:38:37,531 --> 00:38:41,502 MANAGEMENT ANALYST COMES FROM 1058 00:38:41,502 --> 00:38:46,406 THES OFFICE OF HUMAN RESOURCE 1059 00:38:46,406 --> 00:38:47,741 SYSTEMS OF ANALYTICS AND 1060 00:38:47,741 --> 00:38:48,275 INFORMATION DIVISION. 1061 00:38:48,275 --> 00:38:50,777 AS WE CONTINUE TO GROW AS THE 1062 00:38:50,777 --> 00:38:52,112 ORGANIZATION WE HAVE CONTINUED 1063 00:38:52,112 --> 00:38:53,847 IN EXPANDED NEEDS TO MANAGE AND 1064 00:38:53,847 --> 00:38:56,049 TRACK AND DEAL WITH THE 1065 00:38:56,049 --> 00:38:59,019 INCREASED VOLUME. 1066 00:38:59,019 --> 00:39:00,988 WE'RE EXCITED TO HAVE JACK JOIN 1067 00:39:00,988 --> 00:39:02,956 US. 1068 00:39:02,956 --> 00:39:05,459 TRACY HOLT, NEUROSCIENCE 1069 00:39:05,459 --> 00:39:06,226 COMMUNICATIONS, SHE'S GOING TO 1070 00:39:06,226 --> 00:39:07,461 BE AN ADMINISTRATIVE OFFICER FOR 1071 00:39:07,461 --> 00:39:10,264 THE THE OFFICE OF THE DIRECTOR. 1072 00:39:10,264 --> 00:39:14,434 WE HAVE CHRISTEENNA IRAHETA ALSO 1073 00:39:14,434 --> 00:39:15,836 WORKING WITHIN THE NATIONAL 1074 00:39:15,836 --> 00:39:16,737 LIBRARY OF MEDICINE WORKING ON 1075 00:39:16,737 --> 00:39:17,704 OUR WORKPLACE FLEXIBILITY 1076 00:39:17,704 --> 00:39:19,573 PROGRAM. 1077 00:39:19,573 --> 00:39:20,674 TRANSLATABLE TO OUR FOLKS 1078 00:39:20,674 --> 00:39:22,309 WORKING REMOTELY FOR US. 1079 00:39:22,309 --> 00:39:25,145 AS WELL AS WORKING WITH OUR HR 1080 00:39:25,145 --> 00:39:27,447 LIAISON ASSISTING OUR HIRING 1081 00:39:27,447 --> 00:39:28,649 MANAGERS WITH RECRUITMENT AND 1082 00:39:28,649 --> 00:39:31,618 ALSO STAFFING AND ONBOARDING, 1083 00:39:31,618 --> 00:39:34,121 SPENDING A LOT OF TIME AS YOU 1084 00:39:34,121 --> 00:39:35,789 ALL ARE HEARING THIS MORNING 1085 00:39:35,789 --> 00:39:37,190 GROWING THE ORGANIZATION TO 1086 00:39:37,190 --> 00:39:38,959 SUPPORT THE REALIZATION THAT 1087 00:39:38,959 --> 00:39:40,594 WE'RE THE THIRD LARGEST 1088 00:39:40,594 --> 00:39:41,962 INSTITUTE. 1089 00:39:41,962 --> 00:39:45,399 LASTLY I'D LIKE TO WELCOME LEETA 1090 00:39:45,399 --> 00:39:46,600 HARLEM, HR COORDINATOR. 1091 00:39:46,600 --> 00:39:47,467 ONE OF THE THINGS THAT WE'RE 1092 00:39:47,467 --> 00:39:48,702 STRIVING AND WE'RE EXCITED TO 1093 00:39:48,702 --> 00:39:50,771 HAVE HER EXPERTISE ON BOARD WITH 1094 00:39:50,771 --> 00:39:52,406 IS NOT ONLY DO WE WANT TO FIND 1095 00:39:52,406 --> 00:39:55,142 GREAT TALENT, WE WANT TO MAKE 1096 00:39:55,142 --> 00:39:57,010 SURE WHEN WE GET THEM HERE, SET 1097 00:39:57,010 --> 00:39:58,545 THEM UP FOR SUCCESS AND WE HAVE 1098 00:39:58,545 --> 00:40:00,647 A ROBUST ONBOARDING PROGRAM FOR 1099 00:40:00,647 --> 00:40:01,815 OUR EMPLOYEES AS WELL AS OUR 1100 00:40:01,815 --> 00:40:02,382 SUPERVISORS. 1101 00:40:02,382 --> 00:40:04,117 I'D LIKE TO WELCOME THEM ALL TO 1102 00:40:04,117 --> 00:40:04,918 THE NIA FAMILY. 1103 00:40:04,918 --> 00:40:08,455 THANK YOU. 1104 00:40:08,455 --> 00:40:10,390 >> HI, GOOD MORNING. 1105 00:40:10,390 --> 00:40:12,593 I'M CINDY MCCONNELL, NIA 1106 00:40:12,593 --> 00:40:13,894 COMMUNICATIONS DIRECTOR, AND I'D 1107 00:40:13,894 --> 00:40:14,995 LIKE TO WELCOME TWO NEW MEMBERS 1108 00:40:14,995 --> 00:40:18,198 OF OUR TEAM. 1109 00:40:18,198 --> 00:40:20,167 CATIE-MEGAN MORAN IS TECHNICAL 1110 00:40:20,167 --> 00:40:20,901 INFORMATION SPECIALIST IN OUR 1111 00:40:20,901 --> 00:40:23,303 WEB AND DESIGN SERVICES BRANCH. 1112 00:40:23,303 --> 00:40:26,173 SHE'S LEADING QUALITY ASSURANCE 1113 00:40:26,173 --> 00:40:27,474 AND DIGITAL ACCESSIBILITY, 1114 00:40:27,474 --> 00:40:30,544 FONDLY KNOWN AS SECTION 508, 1115 00:40:30,544 --> 00:40:32,279 COMPLIANCE FOR OCPL-MANAGED 1116 00:40:32,279 --> 00:40:32,846 WEBSITES. 1117 00:40:32,846 --> 00:40:33,847 AND WE HAVE QUITE A FEW. 1118 00:40:33,847 --> 00:40:35,716 SHE JOINS US FROM THE FEDERAL 1119 00:40:35,716 --> 00:40:38,151 MARITIME COMMISSION. 1120 00:40:38,151 --> 00:40:40,887 IN OUR MEDIA RELATIONS BRANCH, I 1121 00:40:40,887 --> 00:40:43,724 WELCOME REBECCA SEEL AS THE 1122 00:40:43,724 --> 00:40:44,591 PUBLIC AFFAIRS SPECIALIST. 1123 00:40:44,591 --> 00:40:47,561 SHE IS MANAGING PRESS INQUIRIES 1124 00:40:47,561 --> 00:40:49,630 AND PRESS OUTREACH FOR THE 1125 00:40:49,630 --> 00:40:51,064 ENTIRE INSTITUTE, AND SHE JOINS 1126 00:40:51,064 --> 00:40:52,799 US FROM THE OFFICE OF THE 1127 00:40:52,799 --> 00:40:54,334 ASSISTANT SECRETARY FOR PUBLIC 1128 00:40:54,334 --> 00:40:58,071 AFFAIRS AT HHS. 1129 00:40:58,071 --> 00:41:01,241 WELCOME, CATIE-MEGAN AND 1130 00:41:01,241 --> 00:41:01,475 REBECCA. 1131 00:41:01,475 --> 00:41:05,078 THANK YOU. 1132 00:41:05,078 --> 00:41:06,947 >> AND HI, I WOULD LIKE TO 1133 00:41:06,947 --> 00:41:12,753 INTRODUCE DR. DIANE HANNEMANN 1134 00:41:12,753 --> 00:41:16,023 WHO JOINED OLPIA IN MAY. 1135 00:41:16,023 --> 00:41:17,324 SHE BRINGS MORE THAN 15 YEARS OF 1136 00:41:17,324 --> 00:41:19,426 EXPERIENCE WORKING IN SCIENCE, 1137 00:41:19,426 --> 00:41:20,527 POLICY RESEARCH, PROGRAM 1138 00:41:20,527 --> 00:41:22,162 MANAGEMENT AND COMMUNICATION. 1139 00:41:22,162 --> 00:41:25,332 SHE WAS A SCIENCE WRITER EDITOR 1140 00:41:25,332 --> 00:41:27,100 ON OUR COMMUNICATIONS CONTRACT 1141 00:41:27,100 --> 00:41:32,673 WITH NIA OCPL WITH A FOCUS ON 1142 00:41:32,673 --> 00:41:33,774 ALZHEIMER'S AND RELATED DISEASE 1143 00:41:33,774 --> 00:41:34,875 CONTENT. 1144 00:41:34,875 --> 00:41:36,176 HER FIRST CHAPTER AT NIH BEGAN 1145 00:41:36,176 --> 00:41:38,645 AS ANALYST IN THE NIH OFFICE OF 1146 00:41:38,645 --> 00:41:39,479 SCIENCE POLICY WHERE SHE 1147 00:41:39,479 --> 00:41:40,914 PROVIDED COORDINATION POFL SEE 1148 00:41:40,914 --> 00:41:42,315 ISSUES RELATING TO EMERGING 1149 00:41:42,315 --> 00:41:44,184 TECHNOLOGIES AND ALSO 1150 00:41:44,184 --> 00:41:46,920 COORDINATED NIH ACTIVITIES WITH 1151 00:41:46,920 --> 00:41:47,454 THE WHITE HOUSE OFFICE OF 1152 00:41:47,454 --> 00:41:49,790 SCIENCE AND TECHNOLOGY POLICY. 1153 00:41:49,790 --> 00:41:51,525 DIANE, WHO IS HERE TODAY, IF YOU 1154 00:41:51,525 --> 00:41:55,028 WANT TO STAND UP, HAS HER PH.D. 1155 00:41:55,028 --> 00:41:57,764 IN MOLECULAR BIOPHYSICS AND 1156 00:41:57,764 --> 00:41:58,432 BIOCHEMISTRY FROM YALE 1157 00:41:58,432 --> 00:41:59,766 UNIVERSITY AND SHE'S BEEN THE 1158 00:41:59,766 --> 00:42:01,835 RECIPIENT OF NUMEROUS AWARDS 1159 00:42:01,835 --> 00:42:05,772 INCLUDING THE AAS SCIENCE AND 1160 00:42:05,772 --> 00:42:16,483 TECHNOLOGY POLICY IF FELLOWSHI. 1161 00:42:16,683 --> 00:42:21,321 IN HER NEW ROLE SHE WILL 1162 00:42:21,321 --> 00:42:22,322 FACILITATE ENGAGEMENT WITH 1163 00:42:22,322 --> 00:42:26,059 EXTERNAL PARTNERS INCLUDING 1164 00:42:26,059 --> 00:42:27,694 ADVOCACY -- PLEASE JOIN ME IN 1165 00:42:27,694 --> 00:42:28,095 WELCOMING HER. 1166 00:42:28,095 --> 00:42:29,329 >> GOOD MORNING. 1167 00:42:29,329 --> 00:42:33,100 I'M PLEASED TO PRESENT TO YOU 1168 00:42:33,100 --> 00:42:36,570 THE NEW ACQUISITION OF THE 1169 00:42:36,570 --> 00:42:37,537 INTRAMURAL PROGRAM. 1170 00:42:37,537 --> 00:42:41,308 THE INTRAMURAL PROGRAM EXPANDED 1171 00:42:41,308 --> 00:42:43,009 IN THE LAST FEW YEARS, MOSTLY 1172 00:42:43,009 --> 00:42:48,915 BECAUSE OF THE CREATION OF CARD. 1173 00:42:48,915 --> 00:42:52,119 WE HAVE ACQUIRED OTHER PEOPLE 1174 00:42:52,119 --> 00:42:55,956 THAT CAN HANDLE THE INCREASING 1175 00:42:55,956 --> 00:42:58,458 AMOUNT OF WORKLOAD THAT IS 1176 00:42:58,458 --> 00:43:02,729 COMING FROM THIS EXPANSION. 1177 00:43:02,729 --> 00:43:06,233 SO GREGORY NOLAND, 1178 00:43:06,233 --> 00:43:07,234 ADMINISTRATIVE OFFICER, MOSTLY 1179 00:43:07,234 --> 00:43:11,071 GOING TO WORK ON COMPUTER -- AND 1180 00:43:11,071 --> 00:43:16,343 HE WILL PROVIDE EXPERTISE, HE 1181 00:43:16,343 --> 00:43:17,511 HAS ALREADY LOTS OF EXPERIENCE 1182 00:43:17,511 --> 00:43:21,348 COMING FROM THE CLINICAL CENTER. 1183 00:43:21,348 --> 00:43:27,487 TRACY ANDERSON ALSO JOINS OUR 1184 00:43:27,487 --> 00:43:29,689 ADMINISTRATIVE OFFICE 1185 00:43:29,689 --> 00:43:30,891 SPECIALIZING IN RECRUITMENT, 1186 00:43:30,891 --> 00:43:32,859 RESPONSIBLE FOR REVIEWING AND 1187 00:43:32,859 --> 00:43:34,961 WRITING ACQUISITION DOCUMENTS, 1188 00:43:34,961 --> 00:43:36,930 CONDUCTING MARKET RESEARCH, 1189 00:43:36,930 --> 00:43:38,665 ISSUING SOLICITATIONS AND 1190 00:43:38,665 --> 00:43:41,535 AWARDING CONTRACTORS. 1191 00:43:41,535 --> 00:43:50,310 HE JOINS US FROM MAGNA. 1192 00:43:50,310 --> 00:43:54,447 PRINCESS KING ALSO JOINS AS AN 1193 00:43:54,447 --> 00:43:55,215 ADMINISTRATIVE OFFICER ALSO IN 1194 00:43:55,215 --> 00:43:55,982 THE PROCUREMENT OFFICE. 1195 00:43:55,982 --> 00:43:57,851 SHE WILL PROVIDE MANAGEMENT OF A 1196 00:43:57,851 --> 00:44:00,353 NUMBER OF ADMINISTRATIVE 1197 00:44:00,353 --> 00:44:01,922 SERVICES, MOSTLY THE IN AREA OF 1198 00:44:01,922 --> 00:44:03,557 BUDGET, WHERE SHE IS 1199 00:44:03,557 --> 00:44:06,092 PARTICULARLY EXPERIENCED IN 1200 00:44:06,092 --> 00:44:07,294 FINANCIAL MANAGEMENT, 1201 00:44:07,294 --> 00:44:12,299 PURCHASING, PROCUREMENT, 1202 00:44:12,299 --> 00:44:12,999 CONTRACT ADMINISTRATION AND 1203 00:44:12,999 --> 00:44:13,533 MANAGEMENT. 1204 00:44:13,533 --> 00:44:17,037 SHE JOINS US FROM SJI 1205 00:44:17,037 --> 00:44:18,772 INDUSTRIES. 1206 00:44:18,772 --> 00:44:21,474 KAYLEE BEKLIK, ADMINISTRATIVE 1207 00:44:21,474 --> 00:44:23,810 OFFICER ALSO, SHE WILL BE IN 1208 00:44:23,810 --> 00:44:28,548 THE -- DIRECTLY IN THE NIA/IRP 1209 00:44:28,548 --> 00:44:29,616 STRAYTIVE OFFICE, SUPPORTING 1210 00:44:29,616 --> 00:44:31,952 LABORATORIES WITH ADMINISTRATIVE 1211 00:44:31,952 --> 00:44:33,787 TASKS MOSTLY TO HELP THIS WITH 1212 00:44:33,787 --> 00:44:35,889 TRAVEL, PERSONNEL, AND ALSO THE 1213 00:44:35,889 --> 00:44:36,857 SUMMER INTERNSHIP PROGRAM, WHICH 1214 00:44:36,857 --> 00:44:41,361 YOU KNOW IS VERY, YOU KNOW, 1215 00:44:41,361 --> 00:44:46,299 POPULAR AND VERY LARGE AND SHE 1216 00:44:46,299 --> 00:44:54,608 JOINED US FROM AESTHETIC -- 1217 00:44:54,608 --> 00:44:59,746 KIMBERLEY BILLINGSLEY, STAFF 1218 00:44:59,746 --> 00:45:03,583 SCIENTIST, SHE HAS EXCEPTIONAL 1219 00:45:03,583 --> 00:45:04,918 SKILL IN THE HANDLING AND 1220 00:45:04,918 --> 00:45:07,187 IMPLEMENTATION OF NEW 1221 00:45:07,187 --> 00:45:08,555 TECHNOLOGIES, SO WE REALLY 1222 00:45:08,555 --> 00:45:13,126 WELCOME HER AS ONE OF THE POINT 1223 00:45:13,126 --> 00:45:18,031 SCIENTISTS THAT WILL DEVELOP -- 1224 00:45:18,031 --> 00:45:19,499 SHE WILL BE RESPONSIBLE FOR 1225 00:45:19,499 --> 00:45:21,167 DEVELOPMENT OF THIRD GENERATION 1226 00:45:21,167 --> 00:45:24,971 SEQUENCING, ALSO USING DNA AND 1227 00:45:24,971 --> 00:45:26,406 RNA FROM HUMAN BLOOD, CELL AND 1228 00:45:26,406 --> 00:45:26,973 TISSUE. 1229 00:45:26,973 --> 00:45:28,308 SHE JOINS FROM THE LABORATORY OF 1230 00:45:28,308 --> 00:45:29,276 MENTAL HEALTH AND BEHAVIOR AT 1231 00:45:29,276 --> 00:45:32,679 THE UNIVERSITY OF LIVERPOOL. 1232 00:45:32,679 --> 00:45:34,648 SANDRA FOGEL, PROGRAM 1233 00:45:34,648 --> 00:45:36,883 SPECIALIST, ALSO WILL BE IN THE 1234 00:45:36,883 --> 00:45:39,686 OFFICE OF THE DIRECTOR, CARD, 1235 00:45:39,686 --> 00:45:42,789 ASSISTS WITH ONBOARDING FELLOWS, 1236 00:45:42,789 --> 00:45:44,057 SUMMER STUDENTS AND VOLUNTEERS, 1237 00:45:44,057 --> 00:45:47,727 AND JOINS US FROM THE NAVAL 1238 00:45:47,727 --> 00:45:50,697 SURFACE WARFARE CENTER. 1239 00:45:50,697 --> 00:45:54,200 JERRY ANTONE IS A BIOLOGIST, 1240 00:45:54,200 --> 00:45:59,906 ESPECIALLY IN BASIC AND 1241 00:45:59,906 --> 00:46:02,409 TRANSLATIONAL SCIENCE. 1242 00:46:02,409 --> 00:46:03,610 HE WILL SUPPORT THE RESEARCH 1243 00:46:03,610 --> 00:46:05,578 ACTIVITIES OF CARD AND 1244 00:46:05,578 --> 00:46:07,013 ESPECIALLY BENCH SCIENCE IN 1245 00:46:07,013 --> 00:46:08,882 SUPPORT OF BIOMEDICAL RESEARCH, 1246 00:46:08,882 --> 00:46:10,951 AND JOINS US FROM RESEARCH 1247 00:46:10,951 --> 00:46:12,152 ASSOCIATE POSITION AT THE 1248 00:46:12,152 --> 00:46:13,520 TRANSLATIONAL GENOMICS RESEARCH 1249 00:46:13,520 --> 00:46:17,324 INSTITUTE. 1250 00:46:17,324 --> 00:46:20,827 KIELEE TOEPFER, SHE IS GOING TO 1251 00:46:20,827 --> 00:46:22,696 WORK ON THE NON-HUMAN PRIMATE 1252 00:46:22,696 --> 00:46:24,531 CORE FACILITY. 1253 00:46:24,531 --> 00:46:25,532 SHE PROVIDES SCIENTIFIC 1254 00:46:25,532 --> 00:46:28,268 KNOWLEDGE, TECHNICAL EXPERTISE 1255 00:46:28,268 --> 00:46:31,304 AND INSTRUMENTATION OVERSIGHT, 1256 00:46:31,304 --> 00:46:34,307 AS SHE WILL BE MAINTAINING 1257 00:46:34,307 --> 00:46:37,811 PRIMARY OVERSIGHT OF THE HEALTH 1258 00:46:37,811 --> 00:46:44,718 OF OUR NON-HUMAN PRIMATES, 1259 00:46:44,718 --> 00:46:49,656 FEEDING ISSUES FOR ALL PROJECTS 1260 00:46:49,656 --> 00:46:51,358 OF OUR COMMUNITY AND JOINS US 1261 00:46:51,358 --> 00:46:53,026 FROM THE CHARLES RIVER 1262 00:46:53,026 --> 00:46:55,562 LABORATORIES. 1263 00:46:55,562 --> 00:46:59,499 SO TIANYI HUANG IS A NEW 1264 00:46:59,499 --> 00:47:00,233 TENURE-TRACK INVESTIGATOR. 1265 00:47:00,233 --> 00:47:02,802 HE IS GOING TO BE WORKING ON 1266 00:47:02,802 --> 00:47:06,306 SLEEP HEALTH AND AGING-RELATED 1267 00:47:06,306 --> 00:47:07,674 PHENOTYPES, AND HE'S GOING TO 1268 00:47:07,674 --> 00:47:10,176 OVERSEE THE SLEEP HEALTH AND 1269 00:47:10,176 --> 00:47:11,711 AGING-RELATED PHENOTYPES UNIT, 1270 00:47:11,711 --> 00:47:13,480 CALLED SHARP. 1271 00:47:13,480 --> 00:47:15,882 AND HE JOINS US FROM HARVARD 1272 00:47:15,882 --> 00:47:17,617 MEDICAL SCHOOL, HE JOINED VERY 1273 00:47:17,617 --> 00:47:20,286 RECENTLY. 1274 00:47:20,286 --> 00:47:26,826 INDIRA TURNEY, EARL STADTMAN 1275 00:47:26,826 --> 00:47:27,694 TENURE-TRACK INVESTIGATOR, SHE 1276 00:47:27,694 --> 00:47:29,462 IS GOING TO HELP WITH THE BRAIN 1277 00:47:29,462 --> 00:47:30,330 HEALTH EQUITY UNIT. 1278 00:47:30,330 --> 00:47:32,532 SHE IS ALREADY AN NIH 1279 00:47:32,532 --> 00:47:34,267 DISTINGUISHED SCHOLAR AND JOINS 1280 00:47:34,267 --> 00:47:35,502 US FROM COLUMBIA UNIVERSITY. 1281 00:47:35,502 --> 00:47:42,842 SHE WILL BE WORKING ON HEALTH 1282 00:47:42,842 --> 00:47:44,577 DISPARITY IN COGNITIVE DECLINE 1283 00:47:44,577 --> 00:47:48,748 IN DEMENTIA, AND HER WORK WILL 1284 00:47:48,748 --> 00:47:52,285 BE BASED ON NEUROIMAGING. 1285 00:47:52,285 --> 00:47:57,424 NADER SHEHADEH IS WORKING FOR US 1286 00:47:57,424 --> 00:48:00,593 SAYSAS A BIOLOGIST. 1287 00:48:00,593 --> 00:48:02,028 HE WILL BE SUPPORTING THE 1288 00:48:02,028 --> 00:48:05,865 CLINICAL CORE LAB AND IN 1289 00:48:05,865 --> 00:48:11,037 PERFORMING SOME OF THE ANALYSIS 1290 00:48:11,037 --> 00:48:12,405 FROM SAMPLES COLLECTED IN THE 1291 00:48:12,405 --> 00:48:13,640 STUDIES. 1292 00:48:13,640 --> 00:48:16,042 ALSO STARTING TO DEVELOP SOME 1293 00:48:16,042 --> 00:48:23,049 NEW TESTS THAT -- IN HUMAN. 1294 00:48:23,049 --> 00:48:28,188 SHE'S A MEMBER OF THE -- TEAM 1295 00:48:28,188 --> 00:48:31,825 AND PREVIOUSLY AT NCI. 1296 00:48:31,825 --> 00:48:34,994 TINA GUPTA IS OUR NEW VERY 1297 00:48:34,994 --> 00:48:35,862 BRIGHT STAFF CLINICIAN. 1298 00:48:35,862 --> 00:48:37,997 SHE IS PART OF THE CLINICAL 1299 00:48:37,997 --> 00:48:38,598 RESEARCH CORE. 1300 00:48:38,598 --> 00:48:42,001 SHE PROVIDES CLINICAL OVERSIGHT 1301 00:48:42,001 --> 00:48:45,405 FOR THE BALTIMORE LONGITUDAL 1302 00:48:45,405 --> 00:48:48,074 STUDY, SHE JOINS US FROM SIBLEY 1303 00:48:48,074 --> 00:48:50,777 MEMORIAL HOSPITAL. 1304 00:48:50,777 --> 00:48:52,212 SHE'S ALREADY AT THE CORE VERY 1305 00:48:52,212 --> 00:48:53,179 MUCH INVOLVED IN EVERYTHING THAT 1306 00:48:53,179 --> 00:48:58,218 IS HAPPENING INCLUDING LEARNING 1307 00:48:58,218 --> 00:48:59,552 TO DO MUSCLE AND SKIN BIOPSY. 1308 00:48:59,552 --> 00:49:06,926 THE NEXT SLIDE IS ALLISON 1309 00:49:06,926 --> 00:49:09,195 HERMAN, SHE'S BEEN AT NIA 1310 00:49:09,195 --> 00:49:12,198 BEFORE, SHE'S NOW HIRED AS A 1311 00:49:12,198 --> 00:49:14,033 TENURE-TRACK INVESTIGATOR FROM 1312 00:49:14,033 --> 00:49:15,802 THE STADTMAN PROGRAM. 1313 00:49:15,802 --> 00:49:18,571 SHE'S LEADING THE VASCULAR AGING 1314 00:49:18,571 --> 00:49:20,740 BIOLOGY UNIT IN THE LABORATORY 1315 00:49:20,740 --> 00:49:24,677 OF VASCULAR SCIENCE, AND JOINING 1316 00:49:24,677 --> 00:49:27,213 WITHIN NIA, WHERE SHE WAS AN 1317 00:49:27,213 --> 00:49:31,618 INDEPENDENT RESEARCH SCHOLAR. 1318 00:49:31,618 --> 00:49:36,823 CYNTHIA CHISOLM WAS ALSO WITH US 1319 00:49:36,823 --> 00:49:37,423 AS A CONTRACTOR. 1320 00:49:37,423 --> 00:49:40,193 SHE IS STAFF SCIENTIST IN THE 1321 00:49:40,193 --> 00:49:41,794 SECTION OF COMPARATIVE MEDICINE. 1322 00:49:41,794 --> 00:49:43,930 SHE IS SUPPORTING A WIDE VARIETY 1323 00:49:43,930 --> 00:49:46,332 OF SCIENTIFIC STUDIES ON AGING 1324 00:49:46,332 --> 00:49:48,635 AND ALSO IS RESPONSIBLE FOR MANY 1325 00:49:48,635 --> 00:49:50,803 OF THE TRAINING AND QUALITY 1326 00:49:50,803 --> 00:49:52,906 CONTROL THAT OCCUR IN OUR ANIMAL 1327 00:49:52,906 --> 00:49:55,642 FACILITY, AND SHE WAS ALREADY IN 1328 00:49:55,642 --> 00:49:59,646 CMS BEFORE. 1329 00:49:59,646 --> 00:50:03,016 RACHAEL DOWS, PROGRAM 1330 00:50:03,016 --> 00:50:05,218 SPECIALIST, INTRAMURAL WORKFORCE 1331 00:50:05,218 --> 00:50:07,153 MANAGEMENT SECTION, SHE SUPPORTS 1332 00:50:07,153 --> 00:50:08,621 THE SCIENTIFIC DIRECTOR AND 1333 00:50:08,621 --> 00:50:11,124 HELPS WITH LARGE OPERATION THAT 1334 00:50:11,124 --> 00:50:12,458 OCCURS IN THE OFFICE. 1335 00:50:12,458 --> 00:50:14,427 SHE JOINS US FROM A CONTRACT 1336 00:50:14,427 --> 00:50:15,395 POSITION ALSO WITHIN THE OFFICE 1337 00:50:15,395 --> 00:50:19,265 OF THE SCIENTIFIC DIRECTOR. 1338 00:50:19,265 --> 00:50:24,637 ANNA HOLLAND IS A VERY, VERY 1339 00:50:24,637 --> 00:50:28,074 RECENT ACQUISITION, SHE WAS 1340 00:50:28,074 --> 00:50:29,242 STAFF ASSISTANT IN THE 1341 00:50:29,242 --> 00:50:30,677 INTRAMURAL WORKFORCE MANAGEMENT 1342 00:50:30,677 --> 00:50:32,212 SECTION IN THE OFFICE OF 1343 00:50:32,212 --> 00:50:32,912 SCIENTIFIC DIRECTOR. 1344 00:50:32,912 --> 00:50:37,650 SHE WILL SUPPORT DIRECTOR BY 1345 00:50:37,650 --> 00:50:39,085 MANAGE CALENDAR, ARRANGING 1346 00:50:39,085 --> 00:50:41,054 TRAVEL, MANAGING THE OSD BUDGET 1347 00:50:41,054 --> 00:50:42,956 AND OTHER SPECIAL PROJECTS. 1348 00:50:42,956 --> 00:50:45,658 SHE JOINS US FROM EXECUTIVE 1349 00:50:45,658 --> 00:50:47,760 ASSISTANT POSITION TO THE 1350 00:50:47,760 --> 00:50:50,830 HONORABLE COMMISSIONER ANNA 1351 00:50:50,830 --> 00:50:52,932 GOMEZ. 1352 00:50:52,932 --> 00:50:55,235 TOWANDA COBIA, PROGRAM 1353 00:50:55,235 --> 00:50:56,102 SPECIALIST, SHE WILL BE IN 1354 00:50:56,102 --> 00:50:57,770 CHARGE OF RECRUITMENT AND 1355 00:50:57,770 --> 00:50:58,871 STRATEGIC PLANNING IN THE OFFICE 1356 00:50:58,871 --> 00:50:59,505 OF THE SCIENTIFIC DIRECTOR. 1357 00:50:59,505 --> 00:51:04,244 SHE WILL SUPPORT TITLE 42 1358 00:51:04,244 --> 00:51:06,012 RECRUITMENT AND WILL BE HIGHLY 1359 00:51:06,012 --> 00:51:08,281 INVOLVED IN THE OFFICE OF 1360 00:51:08,281 --> 00:51:09,549 SCIENTIFIC DIRECTOR-HOSTED 1361 00:51:09,549 --> 00:51:12,719 EVENTS AND OTHER IRP-WIDE 1362 00:51:12,719 --> 00:51:13,052 INITIATIVES. 1363 00:51:13,052 --> 00:51:14,454 SHE JOINS US FROM PROGRAM 1364 00:51:14,454 --> 00:51:15,855 ANALYST POSITION AT THE CENTERS 1365 00:51:15,855 --> 00:51:16,889 FOR MEDICARE AND MEDICAID 1366 00:51:16,889 --> 00:51:20,293 SERVICES. 1367 00:51:20,293 --> 00:51:22,595 I THINK THIS IS THE LAST ONE, 1368 00:51:22,595 --> 00:51:25,431 ANANGELA JACKSON ALSO A VERY 1369 00:51:25,431 --> 00:51:26,232 RECENT ACQUISITION. 1370 00:51:26,232 --> 00:51:27,967 SHE'S A PROGRAM SPECIALIST, 1371 00:51:27,967 --> 00:51:29,168 RECRUITMENT AND STRATEGIC 1372 00:51:29,168 --> 00:51:30,136 PLANNING SECTION IN THE OFFICE 1373 00:51:30,136 --> 00:51:31,838 OF THE SCIENTIFIC DIRECTOR. 1374 00:51:31,838 --> 00:51:35,208 SHE SUPPORTS TITLE 1375 00:51:35,208 --> 00:51:36,976 42 RECRUITMENT EFFORTS, AND 1376 00:51:36,976 --> 00:51:39,479 SHE'S ALSO HIGHLY INVOLVED IN 1377 00:51:39,479 --> 00:51:42,915 ALL THE EVENTS IRP-WIDE 1378 00:51:42,915 --> 00:51:44,117 ORGANIZED BY THE OFFICE OF THE 1379 00:51:44,117 --> 00:51:45,218 SCIENTIFIC DIRECTOR, AND JOINS 1380 00:51:45,218 --> 00:51:48,521 US FROM THE BATTALION MISSION 1381 00:51:48,521 --> 00:51:49,389 SUPPORT SPECIALIST POSITION 1382 00:51:49,389 --> 00:51:50,723 WITHIN THE U.S. MILITARY 1383 00:51:50,723 --> 00:51:52,225 ENTRANCE PROCESSING COMMAND. 1384 00:51:52,225 --> 00:52:02,568 THANK YOU VERY MUCH. 1385 00:52:02,869 --> 00:52:04,203 >> THANK YOU FOR ALL THOSE 1386 00:52:04,203 --> 00:52:06,372 INTRODUCTIONS AS WE ENRICH THE 1387 00:52:06,372 --> 00:52:07,974 RESOURCES HERE, THE PEOPLE AT 1388 00:52:07,974 --> 00:52:11,911 NIA WHO MAKE OUR WORK HAPPEN. 1389 00:52:11,911 --> 00:52:12,779 FINALLY, WE WANT TO PRESENT ALL 1390 00:52:12,779 --> 00:52:14,714 THESE LINKS TO YOU, IN CASE YOU 1391 00:52:14,714 --> 00:52:15,982 HAVEN'T HEARD ENOUGH FROM US OR 1392 00:52:15,982 --> 00:52:18,051 OF US, WAYS TO STAY INFORMED AND 1393 00:52:18,051 --> 00:52:19,052 CONNECTED BETWEEN OUR MEETINGS. 1394 00:52:19,052 --> 00:52:19,952 WE HOPE YOU TAKE ADVANTAGE OF 1395 00:52:19,952 --> 00:52:22,789 THIS. 1396 00:52:22,789 --> 00:52:24,090 AND I THINK WE'RE NOW OPEN TO 1397 00:52:24,090 --> 00:52:25,091 QUESTIONS OR DISCUSSIONS ABOUT 1398 00:52:25,091 --> 00:52:25,992 ANYTHING YOU'VE HEARD SO FAR 1399 00:52:25,992 --> 00:52:34,200 THIS MORNING. 1400 00:52:34,200 --> 00:52:44,143 >> QUESTIONS FOR DR. HODES? 1401 00:52:44,143 --> 00:52:44,377 SANJAY? 1402 00:52:44,377 --> 00:52:46,245 >> THANK YOU, DR. HODES, FOR ALL 1403 00:52:46,245 --> 00:52:48,014 THAT INFORMATION. 1404 00:52:48,014 --> 00:52:49,649 IS IT POSSIBLE YOU COULD SHARE 1405 00:52:49,649 --> 00:52:51,184 WITH US SOMETHING ABOUT THE 1406 00:52:51,184 --> 00:52:53,553 NATIONAL INSTITUTE FOR DEMENTIA 1407 00:52:53,553 --> 00:52:55,455 AND HOW DOES IT RELATE TO NIA? 1408 00:52:55,455 --> 00:53:01,728 I JUST AM NOT INFORMED ABOUT IT. 1409 00:53:01,728 --> 00:53:07,967 >> AS NOTED IN PASSING, THIS WAS 1410 00:53:07,967 --> 00:53:11,037 LEGISLATION NOT IN 1411 00:53:11,037 --> 00:53:12,472 APPROPRIATIONS BULL SO CALLED 1412 00:53:12,472 --> 00:53:13,806 AUTHORIZING LEGISLATION THAT 1413 00:53:13,806 --> 00:53:16,976 PROPOSED A REORGANIZATION OF NIH 1414 00:53:16,976 --> 00:53:19,679 OVERALL TAKING ITS 27 INSTITUTES 1415 00:53:19,679 --> 00:53:20,780 AND CENTERS DOWN TO ABOUT 15. 1416 00:53:20,780 --> 00:53:21,914 SO THERE'S ENORMOUS CHANGE AS 1417 00:53:21,914 --> 00:53:24,684 YOU CAN IMAGINE, VERY FEW OF THE 1418 00:53:24,684 --> 00:53:26,452 CURRENT INSTITUTES RETAIN THEIR 1419 00:53:26,452 --> 00:53:30,590 SINK LAIRSINGULARITY OF PURPOSE. 1420 00:53:30,590 --> 00:53:35,561 SO NIA APPEARS -- DEMENTIA DOES 1421 00:53:35,561 --> 00:53:35,995 APPEAR. 1422 00:53:35,995 --> 00:53:39,799 CHILD HEALTH DISAPPEARS -- MANY 1423 00:53:39,799 --> 00:53:40,933 DISAPPEAR AND OR EMERGED. 1424 00:53:40,933 --> 00:53:43,469 AT THIS STAGE, THERE'S REALLY NO 1425 00:53:43,469 --> 00:53:46,072 FORWARD LEGISLATIVE PROCESS OR 1426 00:53:46,072 --> 00:53:46,506 PROGRESS. 1427 00:53:46,506 --> 00:53:48,374 IT'S NOT A MATTER OF 1428 00:53:48,374 --> 00:53:49,609 APPROPRIATIONS YET, SO IT'S A 1429 00:53:49,609 --> 00:53:51,043 FUNNY STATE IN WHICH WE WAIT TO 1430 00:53:51,043 --> 00:53:58,484 SEE WHAT EVENTS UNFOLD. 1431 00:53:58,484 --> 00:54:00,353 RECEIVED A FAIR BIT OF A I 1432 00:54:00,353 --> 00:54:00,686 TENSION. 1433 00:54:00,686 --> 00:54:04,190 AND IF YOU WANT TO -- 1434 00:54:04,190 --> 00:54:07,160 >> SO ACTUALLY, SANJAY, I JUST 1435 00:54:07,160 --> 00:54:09,595 SENT YOU THE LINKS TO THE AGS 1436 00:54:09,595 --> 00:54:10,663 COMMENT LETTER ON THIS AND ALSO 1437 00:54:10,663 --> 00:54:16,169 WE HAD AN EDITORIAL BY MARK 1438 00:54:16,169 --> 00:54:22,975 SUPIANO IN THE JOURNAL OF JAIRNT 1439 00:54:22,975 --> 00:54:23,976 GERENTOLOGICAL NURSING WHICH I'M 1440 00:54:23,976 --> 00:54:25,178 PLEASED TO SHARE WITH ALL 1441 00:54:25,178 --> 00:54:26,946 ACCOUNTS BOTH WITH ALL 1442 00:54:26,946 --> 00:54:27,880 COUNCILMEMBERS. 1443 00:54:27,880 --> 00:54:28,915 THE AUTHORIZING LANGUAGE IS 1444 00:54:28,915 --> 00:54:30,650 BURIED IN THE HOUSE 1445 00:54:30,650 --> 00:54:31,384 APPROPRIATIONS BILL AS I 1446 00:54:31,384 --> 00:54:32,685 UNDERSTAND IT WHICH SEEMS TO BE 1447 00:54:32,685 --> 00:54:33,553 DEAD IN THE WATER IN THIS 1448 00:54:33,553 --> 00:54:34,220 CONGRESS. 1449 00:54:34,220 --> 00:54:39,258 THEY'RE CURRENTLY NEGOTIATING A 1450 00:54:39,258 --> 00:54:40,927 CONTINUING RESOLUTION IN BOTH 1451 00:54:40,927 --> 00:54:45,298 CHAMBERS WITH SOME DISAGREEMENT 1452 00:54:45,298 --> 00:54:46,365 ABOUT HOW LONG THAT RESOLUTION 1453 00:54:46,365 --> 00:54:48,501 WOULD TAKE US, BUT TRYING TO 1454 00:54:48,501 --> 00:54:52,004 AVOID THE SEPTEMBER 30TH CLIFF 1455 00:54:52,004 --> 00:54:54,640 OF GOVERNMENT SHUTDOWN. 1456 00:54:54,640 --> 00:54:56,909 WHICH IS NOT GREAT FOR EITHER 1457 00:54:56,909 --> 00:54:59,512 PARTY TO HAVE ON THE CUSP OF A 1458 00:54:59,512 --> 00:55:00,480 NATIONAL ELECTION, I WOULD SAY, 1459 00:55:00,480 --> 00:55:04,016 SO I THINK THERE'S -- THEY WILL 1460 00:55:04,016 --> 00:55:05,451 ARRIVE AT A CONTINUING 1461 00:55:05,451 --> 00:55:05,885 RESOLUTION. 1462 00:55:05,885 --> 00:55:09,255 SO THE QUESTION REALLY IS, WILL 1463 00:55:09,255 --> 00:55:11,023 THIS RE-APPEAR IN THE NEXT 1464 00:55:11,023 --> 00:55:17,497 CONGRESS, AND I THINK THAT THERE 1465 00:55:17,497 --> 00:55:19,265 WAS A VERY STRONG OUTPOURING OF 1466 00:55:19,265 --> 00:55:21,601 LETTERS, BECAUSE AS RICHARD 1467 00:55:21,601 --> 00:55:23,035 NOTED, IT WASN'T JUST THE NIA 1468 00:55:23,035 --> 00:55:25,972 THAT WAS GOING TO BE IMPACTED. 1469 00:55:25,972 --> 00:55:27,573 NHLBI WAS GOING TO DISAPPEAR AND 1470 00:55:27,573 --> 00:55:30,610 BE MELDED WITH NIDDK. 1471 00:55:30,610 --> 00:55:33,846 SO PRETTY MUCH EVERYONE, AT 1472 00:55:33,846 --> 00:55:34,947 LEAST ON THE ORGANIZATIONAL 1473 00:55:34,947 --> 00:55:36,249 SIDE, SORT OF PERKED UP AND 1474 00:55:36,249 --> 00:55:37,216 SUBMITTED LETTERS. 1475 00:55:37,216 --> 00:55:40,119 SO IT REMAINS TO BE SEEN. 1476 00:55:40,119 --> 00:55:41,554 FOR THOSE SORT OF WITH INTEREST 1477 00:55:41,554 --> 00:55:42,755 IN WHAT'S GOING ON IN THE SENATE 1478 00:55:42,755 --> 00:55:46,058 ON THIS, DR. CASSIDY HAS A WHITE 1479 00:55:46,058 --> 00:55:49,662 PAPER PROPOSAL THAT IS FOCUSED 1480 00:55:49,662 --> 00:55:55,034 ON RESTRUCTURING NIH WRIT LARGE, 1481 00:55:55,034 --> 00:55:58,037 IT HASN'T PEERED IN AUTHORIZED 1482 00:55:58,037 --> 00:55:59,906 LEGISLATION AT ALL. 1483 00:55:59,906 --> 00:56:04,076 FINALLY, THE HOUSE PROPOSAL IS 1484 00:56:04,076 --> 00:56:05,678 INTERESTING, AND AGS COMMENTED 1485 00:56:05,678 --> 00:56:07,380 ON THE FIRST RECOMMENDATION, 1486 00:56:07,380 --> 00:56:09,582 WHICH IS ANY REORGANIZATION OF 1487 00:56:09,582 --> 00:56:15,388 NIH SHOULD BE PRECEDED BY AN 1488 00:56:15,388 --> 00:56:17,056 EXTERNAL COMMISSION REPORT BY AN 1489 00:56:17,056 --> 00:56:18,824 ORGANIZATION LIKE THE NATIONAL 1490 00:56:18,824 --> 00:56:19,692 ACADEMY OF SCIENCE, ENGINEERING 1491 00:56:19,692 --> 00:56:23,729 AND MEDICINE, AND THEN THAT 1492 00:56:23,729 --> 00:56:26,532 WOULD BE FOLLOWED BY A TRUE 1493 00:56:26,532 --> 00:56:27,833 BIPARTISAN LOOK AT WHAT THAT 1494 00:56:27,833 --> 00:56:30,036 REPORT SAYS. 1495 00:56:30,036 --> 00:56:32,305 AND CERTAINLY CALLED FOR THE 1496 00:56:32,305 --> 00:56:36,309 HOUSE PROPOSAL DID NOT REFLECT 1497 00:56:36,309 --> 00:56:38,277 INPUT FROM THE SCIENTIFIC 1498 00:56:38,277 --> 00:56:40,479 COMMUNITY, NOR DID IT REFLECT 1499 00:56:40,479 --> 00:56:42,582 INPUT FROM THE INSTITUTES 1500 00:56:42,582 --> 00:56:48,521 THEMSELVES. 1501 00:56:48,521 --> 00:56:51,123 SO I THINK IT'S NOT GOING 1502 00:56:51,123 --> 00:56:53,859 ANYPLACE IN THIS CONGRESS BUT 1503 00:56:53,859 --> 00:56:55,294 GUESS I SHOULD ALWAYS END WITH 1504 00:56:55,294 --> 00:56:56,963 THE NEVER SAY NEVER CAVEAT OF 1505 00:56:56,963 --> 00:56:58,497 PEOPLE WHO SPEND FAR MORE TIME 1506 00:56:58,497 --> 00:56:59,565 ON THE HILL THAN I DO. 1507 00:56:59,565 --> 00:57:00,600 >> THANK YOU, APPRECIATE THE 1508 00:57:00,600 --> 00:57:01,000 COMMENTS. 1509 00:57:01,000 --> 00:57:02,401 AS A GENERALITY, WE DO NOT 1510 00:57:02,401 --> 00:57:04,804 COMMENT ON PENDING LEGISLATION, 1511 00:57:04,804 --> 00:57:09,408 SO THANK YOU FOR YOUR INPUT. 1512 00:57:09,408 --> 00:57:15,014 >> JUST RELATED TO THAT, STLR 1513 00:57:15,014 --> 00:57:16,983 ANY -- DO WE KNOW MUCH ABOUT THE 1514 00:57:16,983 --> 00:57:19,952 DRIVING -- ANY CONCERNS, FORCES 1515 00:57:19,952 --> 00:57:21,387 OR PERSPECTIVES THAT WOULD PUSH 1516 00:57:21,387 --> 00:57:24,323 THE IDEAS FOR REORGANIZING OR 1517 00:57:24,323 --> 00:57:27,827 MAKING THESE CHANGES, OR IS THAT 1518 00:57:27,827 --> 00:57:30,630 TOO MUCH COMMENTING ON PENDING 1519 00:57:30,630 --> 00:57:30,863 THINGS? 1520 00:57:30,863 --> 00:57:32,832 >> I THINK I'M THE RESIDENT 1521 00:57:32,832 --> 00:57:33,699 COMMENTATOR ON THAT. 1522 00:57:33,699 --> 00:57:35,935 >> I MEAN, ARE THERE THINGS -- 1523 00:57:35,935 --> 00:57:38,638 ARE THERE CONCERNS ABOUT 1524 00:57:38,638 --> 00:57:39,572 INSTITUTES OR WHAT DRIVES THIS? 1525 00:57:39,572 --> 00:57:44,810 >> YEAH, SO THE SECOND HALF OF 1526 00:57:44,810 --> 00:57:46,979 THE PROPOSAL, THE RESTRUCTURING 1527 00:57:46,979 --> 00:57:48,180 PROPOSAL IN THE HOUSE IS FOCUSED 1528 00:57:48,180 --> 00:57:50,483 ON REDUCING THE GOVERNMENT 1529 00:57:50,483 --> 00:57:53,686 SUPPORT FOR INDIRECT COSTS. 1530 00:57:53,686 --> 00:57:56,989 SO WE THINK THAT MIGHT BE THE 1531 00:57:56,989 --> 00:58:00,259 DRIVING PIECE OF THIS, SO THE 1532 00:58:00,259 --> 00:58:02,495 REORGANIZATION IS ONE PIECE, BUT 1533 00:58:02,495 --> 00:58:04,664 THE ACTUAL REAL DRIVER IS THAT 1534 00:58:04,664 --> 00:58:07,967 WE SHOULD SHIFT MORE OF THE 1535 00:58:07,967 --> 00:58:09,969 INDIRECT COSTS OF DOING RESEARCH 1536 00:58:09,969 --> 00:58:11,203 OFF ON THE INSTITUTIONS THAT DO 1537 00:58:11,203 --> 00:58:11,737 THAT RESEARCH. 1538 00:58:11,737 --> 00:58:15,875 AND AGAIN, THAT WOULD NEED, LIKE 1539 00:58:15,875 --> 00:58:17,410 THE RESTRUCTURING, IT SHOULD 1540 00:58:17,410 --> 00:58:19,979 HAVE A ROBUST DISCUSSION WITH 1541 00:58:19,979 --> 00:58:24,250 PEOPLE WHO ARE EXPERTS EXTERNAL 1542 00:58:24,250 --> 00:58:29,822 TO NIH AS A PART OF THAT NASEM 1543 00:58:29,822 --> 00:58:30,056 REPORT. 1544 00:58:30,056 --> 00:58:32,391 >> THAT'S HELPFUL. 1545 00:58:32,391 --> 00:58:33,592 >> ANY OTHER COMMENTS OR 1546 00:58:33,592 --> 00:58:34,927 QUESTIONS? 1547 00:58:34,927 --> 00:58:36,762 >> I JUST HAVE A QUESTION. 1548 00:58:36,762 --> 00:58:39,899 THIS IS YANIRA. 1549 00:58:39,899 --> 00:58:41,734 NANCY, WHO IS LEADING THAT 1550 00:58:41,734 --> 00:58:43,069 LEGISLATION IN CONGRESS? 1551 00:58:43,069 --> 00:58:44,904 DO YOU KNOW? 1552 00:58:44,904 --> 00:58:47,473 >> OH, YANIRA, I DO KNOW BUT I 1553 00:58:47,473 --> 00:58:50,643 DON'T HAVE THE NAME IN MY HEAD. 1554 00:58:50,643 --> 00:58:54,747 SHE IS ACTUALLY NOT RUNNING FOR 1555 00:58:54,747 --> 00:58:55,047 RE-ELECTION. 1556 00:58:55,047 --> 00:58:58,484 I CAN SEND THAT TO YOU. 1557 00:58:58,484 --> 00:59:00,653 BUT IT IS -- THE COMMITTEE THAT 1558 00:59:00,653 --> 00:59:01,887 IS LEADING IS THE ENERGY AND 1559 00:59:01,887 --> 00:59:02,421 COMMERCE COMMITTEE. 1560 00:59:02,421 --> 00:59:04,190 >> OKAY. 1561 00:59:04,190 --> 00:59:05,725 IF YOU CAN SEND SOMETHING, THAT 1562 00:59:05,725 --> 00:59:06,726 WOULD BE GREAT. 1563 00:59:06,726 --> 00:59:10,463 THANKS, NANCY. 1564 00:59:10,463 --> 00:59:12,331 >> JUST TWO BRIEF COMMENTS BASED 1565 00:59:12,331 --> 00:59:17,703 ON THE PRESENTATIONS. 1566 00:59:17,703 --> 00:59:19,004 I LIKE SEEING THE ONGOING IN 1567 00:59:19,004 --> 00:59:21,240 TERMS OF THERAPEUTIC TARGETS AND 1568 00:59:21,240 --> 00:59:23,042 MECHANISMS THE ONGOING DIVERSITY 1569 00:59:23,042 --> 00:59:24,076 OF TARGETS, SO THANK YOU FOR 1570 00:59:24,076 --> 00:59:24,744 YOUR UPDATE ON THAT. 1571 00:59:24,744 --> 00:59:26,412 I THINK IT'S REALLY HEALTHY FOR 1572 00:59:26,412 --> 00:59:27,847 THE FIELD. 1573 00:59:27,847 --> 00:59:30,983 AND AMYLOID AND TAU CONTINUES, 1574 00:59:30,983 --> 00:59:33,252 BUT HAVING THE DIVERSE BIOLOGY, 1575 00:59:33,252 --> 00:59:34,987 THINK IT'S GREAT TO SEE THAT. I 1576 00:59:34,987 --> 00:59:36,555 THINK NIA HAS DONE AN AWESOME 1577 00:59:36,555 --> 00:59:37,556 JOB IN THAT PIPELINE. 1578 00:59:37,556 --> 00:59:39,925 THEN SECONDLY, JUST SEEING ALL 1579 00:59:39,925 --> 00:59:43,462 THE NEW PEOPLE JOIN, IT'S JUST A 1580 00:59:43,462 --> 00:59:45,598 REMINDER THAT THIS IS A VERY 1581 00:59:45,598 --> 00:59:46,365 MULTIDISCIPLINARY EFFORT, AND 1582 00:59:46,365 --> 00:59:48,200 PEOPLE ARE COMING FROM VARIOUS 1583 00:59:48,200 --> 00:59:49,468 BACKGROUNDS AND DISCIPLINES, SO 1584 00:59:49,468 --> 00:59:50,669 I THINK THAT'S REALLY HEALTHY 1585 00:59:50,669 --> 00:59:52,972 FOR THE INSTITUTE AS WELL. 1586 00:59:52,972 --> 00:59:58,110 SO APPRECIATE THOSE UPDATES. 1587 00:59:58,110 --> 00:59:59,478 >> TO THAT, FRANK, I'LL JUST 1588 00:59:59,478 --> 01:00:00,546 COMMENT IN RECOGNITION AND 1589 01:00:00,546 --> 01:00:02,214 APPRECIATION OF OUR STAFF. 1590 01:00:02,214 --> 01:00:06,652 AS THE INSTITUTE, ITS BUDGET, 1591 01:00:06,652 --> 01:00:07,653 APPROPRIATIONS HAVE INCREASED, 1592 01:00:07,653 --> 01:00:09,288 THERE'S BEEN A LAG, WE'RE JUST 1593 01:00:09,288 --> 01:00:10,856 CATCHING UP NOW IN TERMS OF 1594 01:00:10,856 --> 01:00:15,561 STAFF, WHICH IS TO SAY THAT THE 1595 01:00:15,561 --> 01:00:18,497 WORKLOAD OF OUR STAFF HAS BEEN 1596 01:00:18,497 --> 01:00:19,932 ENORMOUS, ABOVE AND BEYOND 1597 01:00:19,932 --> 01:00:20,766 REASONABLE EXPECTATIONS AND IN 1598 01:00:20,766 --> 01:00:22,501 ADDITION TO BRINGING A DIVERSITY 1599 01:00:22,501 --> 01:00:24,937 OF TALENT, WE'RE ALSO GETTING 1600 01:00:24,937 --> 01:00:26,839 SOME MUCH NEEDED HELP AND 1601 01:00:26,839 --> 01:00:27,706 REINFORCEMENT TO A STAFF THAT'S 1602 01:00:27,706 --> 01:00:30,009 BEEN DOING YEOMAN'S WORK PLUS 1603 01:00:30,009 --> 01:00:31,210 OVER THESE PAST YEARS. 1604 01:00:31,210 --> 01:00:32,545 >> THAT'S GREAT AND AS ONE OF 1605 01:00:32,545 --> 01:00:33,879 THE GUILTY PEOPLE CREATING SOME 1606 01:00:33,879 --> 01:00:35,047 OF THAT WORK, REALLY APPRECIATE 1607 01:00:35,047 --> 01:00:35,748 THEY'RE GETTING HELP. 1608 01:00:35,748 --> 01:00:41,520 THANK YOU. 1609 01:00:41,520 --> 01:00:46,859 >> VERY GOOD, THANK YOU. 1610 01:00:46,859 --> 01:00:47,092 SANJAY? 1611 01:00:47,092 --> 01:00:49,161 >> I JUST WANT TO ECHO WHAT 1612 01:00:49,161 --> 01:00:50,863 FRANK JUST SAID AND ALSO THE 1613 01:00:50,863 --> 01:00:51,630 APPLICATION IN THE REAL WORLD, 1614 01:00:51,630 --> 01:00:53,566 WHEN IT COMES TO THERAPEUTICS, 1615 01:00:53,566 --> 01:00:55,968 HOW THE FINDINGS CAN REPLY TO 1616 01:00:55,968 --> 01:00:58,003 PATIENTS WITH MULTIPLE 1617 01:00:58,003 --> 01:00:58,971 COMORBIDITIES AND ALL THAT, AND 1618 01:00:58,971 --> 01:01:01,106 I THINK THAT AREA OF RESEARCH IS 1619 01:01:01,106 --> 01:01:01,974 ALSO PIVOTAL THAT YOU'RE 1620 01:01:01,974 --> 01:01:08,247 SUPPORTING. 1621 01:01:08,247 --> 01:01:09,682 >> OKAY. 1622 01:01:09,682 --> 01:01:12,384 WE'LL MOVE ON THEN. 1623 01:01:12,384 --> 01:01:14,386 COUNCILMEMBERS IN OUR ELECTRONIC 1624 01:01:14,386 --> 01:01:15,821 COUNCIL BOOK IS THE MINUTES FROM 1625 01:01:15,821 --> 01:01:19,959 OUR LAST MEETING. 1626 01:01:19,959 --> 01:01:21,894 FIRST OFF, I'D LIKE TO ASK IF 1627 01:01:21,894 --> 01:01:25,731 ANYONE HAS ANY CORRECTIONS OR 1628 01:01:25,731 --> 01:01:29,435 COMMENTS ON THOSE MINUTES? 1629 01:01:29,435 --> 01:01:31,403 NOT HEARING ANY, IF I COULD GET 1630 01:01:31,403 --> 01:01:33,239 CONCURRENCE FOR THOSE MINUTES 1631 01:01:33,239 --> 01:01:36,742 FROM THE LAST MEETING? 1632 01:01:36,742 --> 01:01:38,611 SECOND? 1633 01:01:38,611 --> 01:01:40,646 ALL IN FAVOR? 1634 01:01:40,646 --> 01:01:43,616 ANY OPPOSED? 1635 01:01:43,616 --> 01:01:44,884 SO WE HAVE CONCURRENCE FOR THE 1636 01:01:44,884 --> 01:01:46,318 MINUTES FROM THE LAST COUNCIL 1637 01:01:46,318 --> 01:01:47,186 MEETING. 1638 01:01:47,186 --> 01:01:52,524 THANK YOU VERY MUCH. 1639 01:01:52,524 --> 01:01:54,894 JUST AS ANNOUNCEMENTS FOR OUR 1640 01:01:54,894 --> 01:01:56,161 FUTURE MEETING DATES, THEY'RE UP 1641 01:01:56,161 --> 01:01:59,265 ON THE SCREEN NOW. 1642 01:01:59,265 --> 01:02:02,601 WE HAVE BOTH 2025 AND 2026. 1643 01:02:02,601 --> 01:02:03,035 2026 1644 01:02:03,035 --> 01:02:03,602 MEETING DATES. 1645 01:02:03,602 --> 01:02:06,772 WE CAN SEND THOSE TO YOU ALL TOO 1646 01:02:06,772 --> 01:02:08,274 TO PLEASE MARK YOUR CALENDAR, 1647 01:02:08,274 --> 01:02:09,675 BLOCK YOUR CALENDARS FOR THOSE 1648 01:02:09,675 --> 01:02:15,047 FUTURE DATES. 1649 01:02:15,047 --> 01:02:18,417 BECAUSE WE WANT TO ENSURE THAT 1650 01:02:18,417 --> 01:02:20,185 EVERYONE WILL BE ABLE TO COME TO 1651 01:02:20,185 --> 01:02:21,020 THOSE MEETINGS. 1652 01:02:21,020 --> 01:02:25,391 AGAIN, WE ALWAYS HAVE OUR MAY 1653 01:02:25,391 --> 01:02:26,692 AND OUR SEPTEMBER COUNCIL 1654 01:02:26,692 --> 01:02:28,027 MEETINGS IN PERSON AND OUR 1655 01:02:28,027 --> 01:02:34,833 JANUARY ONES WILL BE VIRTUAL. 1656 01:02:34,833 --> 01:02:38,771 WITH THAT, WE HAVE A REALLY 1657 01:02:38,771 --> 01:02:40,039 BITTERSWEET KIND OF PRESENTATION 1658 01:02:40,039 --> 01:02:42,007 NEXT OF OUR RETIRING MEMBERS FOR 1659 01:02:42,007 --> 01:02:43,208 2024, AND I'LL TURN IT BACK OVER 1660 01:02:43,208 --> 01:02:45,044 TO RICHARD FOR THOSE. 1661 01:02:45,044 --> 01:02:47,780 >> YES, BITTERSWEET INDEED. 1662 01:02:47,780 --> 01:02:49,381 TIME FLIES AS REFLECTED IN THOSE 1663 01:02:49,381 --> 01:02:53,752 OF YOU WHO ARE NOW COMPLETING 1664 01:02:53,752 --> 01:02:55,154 THE TERM ON COUNCIL AND MOVING 1665 01:02:55,154 --> 01:02:56,255 ON. 1666 01:02:56,255 --> 01:02:57,790 SO THIS IS AN OPPORTUNITY TO 1667 01:02:57,790 --> 01:03:00,726 THANK YOU, EXPRESS OUR 1668 01:03:00,726 --> 01:03:03,095 APPRECIATION AND TO ASK EACH OF 1669 01:03:03,095 --> 01:03:04,196 YOU IF YOU'D LIKE TO EXPRESS 1670 01:03:04,196 --> 01:03:05,397 SOME WORDS OF WISDOM AS YOU'VE 1671 01:03:05,397 --> 01:03:06,966 BEEN DOING FOR THE PAST FOUR 1672 01:03:06,966 --> 01:03:11,670 YEARS. 1673 01:03:11,670 --> 01:03:13,339 SO YADONG, LET ME BEGIN WITH 1674 01:03:13,339 --> 01:03:13,539 YOU. 1675 01:03:13,539 --> 01:03:15,407 THANK YOU FOR THE ENORMOUS 1676 01:03:15,407 --> 01:03:17,242 RESOURCE YOU'VE BEEN TO ALL OF 1677 01:03:17,242 --> 01:03:19,645 US IN NEUROSCIENCE, 1678 01:03:19,645 --> 01:03:20,813 NEUROBIOLOGY, BASIC SCIENCE AND 1679 01:03:20,813 --> 01:03:22,114 TRANSLATION ON COUNCIL AND IN 1680 01:03:22,114 --> 01:03:22,748 ANCILLARY ACTIVITIES. 1681 01:03:22,748 --> 01:03:23,949 YOUR WISDOM, YOUR ROLE IN 1682 01:03:23,949 --> 01:03:25,684 PARTICULAR IN SPECIAL ACTIONS AS 1683 01:03:25,684 --> 01:03:27,086 WELL AS GENERAL CONVERSATION HAS 1684 01:03:27,086 --> 01:03:28,287 BEEN A GREAT ASSET. 1685 01:03:28,287 --> 01:03:29,688 WE'LL SURE MISS THIS AND HOPE 1686 01:03:29,688 --> 01:03:31,991 THAT WE CAN HAVE THE NEXT 1687 01:03:31,991 --> 01:03:35,694 GENERATION OF EXPERTISE AND 1688 01:03:35,694 --> 01:03:37,196 COMMITMENT REFLECT THE SAME 1689 01:03:37,196 --> 01:03:38,297 QUALITY YOU'VE GIVEN TO US, SO 1690 01:03:38,297 --> 01:03:39,598 PLEASE ASK YOU TO EXPRESS A FEW 1691 01:03:39,598 --> 01:03:42,434 WORDS IF YOU'D LIKE. 1692 01:03:42,434 --> 01:03:46,138 >> THANK YOU VERY MUCH FOR THE 1693 01:03:46,138 --> 01:03:47,339 NICE WORDS. 1694 01:03:47,339 --> 01:03:48,774 I JUST REALLY WANT TO SAY A FEW 1695 01:03:48,774 --> 01:03:49,641 WORDS HERE. 1696 01:03:49,641 --> 01:03:51,577 IT HAS BEEN A PLEASURE TO 1697 01:03:51,577 --> 01:03:55,080 WORKING ON THIS COUNCIL, WORKING 1698 01:03:55,080 --> 01:03:57,149 WITH EVERYONE HERE, ENJOYABLE. 1699 01:03:57,149 --> 01:04:00,119 I SHOULD SAY BEFORE I JOINED 1700 01:04:00,119 --> 01:04:03,756 THIS COUNCIL, I KNOW I'VE BEEN 1701 01:04:03,756 --> 01:04:07,693 VERY APPRECIATIVE FOR THE 1702 01:04:07,693 --> 01:04:10,429 SUPPORT FOR MANY NIA GRANTS BUT 1703 01:04:10,429 --> 01:04:12,765 AFTER JOINING I DEFINITELY 1704 01:04:12,765 --> 01:04:13,966 LEARNED A LOT. 1705 01:04:13,966 --> 01:04:14,800 WORKING ON THE CONCEPT 1706 01:04:14,800 --> 01:04:16,268 CLEARANCE, I REALLY RECOGNIZE 1707 01:04:16,268 --> 01:04:18,070 HOW MUCH EFFORT NIA STAFF REALLY 1708 01:04:18,070 --> 01:04:21,140 PUT ON AND USUALLY START FROM 1709 01:04:21,140 --> 01:04:24,076 WORKSHOP, ORGANIZE THOSE 1710 01:04:24,076 --> 01:04:25,277 MEETING -- CONCEPT AND DISCUSS 1711 01:04:25,277 --> 01:04:27,446 INTERNALLY AND THEN PUT ON THE 1712 01:04:27,446 --> 01:04:27,913 COUNCIL. 1713 01:04:27,913 --> 01:04:29,515 SO THIS IS REALLY LEARNING 1714 01:04:29,515 --> 01:04:34,486 ACTUALLY TO ME, KNOWING THIS, I 1715 01:04:34,486 --> 01:04:36,221 REALLY APPRECIATE FOR THIS 1716 01:04:36,221 --> 01:04:40,392 LEADERSHIP OF NIA AND ALSO THE 1717 01:04:40,392 --> 01:04:42,795 STAFF, PROGRAM OFFICERS PUT ALL 1718 01:04:42,795 --> 01:04:47,466 THIS EFFORT AND MAKE THOSE -- 1719 01:04:47,466 --> 01:04:51,603 AND ALSO VERY FULL LOOKING 1720 01:04:51,603 --> 01:04:52,504 CONCEPT TO GO THROUGH THIS 1721 01:04:52,504 --> 01:04:55,174 COUNCIL. 1722 01:04:55,174 --> 01:04:56,575 SECOND I ALSO REALLY ENJOY 1723 01:04:56,575 --> 01:04:59,545 WORKING WITH ALL THESE 1724 01:04:59,545 --> 01:05:00,512 COUNCILMEMBERS AND KNOWING EACH 1725 01:05:00,512 --> 01:05:01,547 ONE, A LOT OF DISCUSSION AND 1726 01:05:01,547 --> 01:05:04,750 NICE MEMORY, ESPECIALLY IN SOME 1727 01:05:04,750 --> 01:05:06,151 DINNERS, LIKE YESTERDAY'S 1728 01:05:06,151 --> 01:05:07,653 DINNER, I LEARNED QUITE A LOT 1729 01:05:07,653 --> 01:05:14,860 FROM EACH OTHER MEMBERS, AND 1730 01:05:14,860 --> 01:05:16,295 NEVER FORGOT SOME OF THOSE 1731 01:05:16,295 --> 01:05:17,429 STORIES, SO REALLY ENJOY WORKING 1732 01:05:17,429 --> 01:05:18,397 WITH EVERYONE, AND AGAIN THANK 1733 01:05:18,397 --> 01:05:23,235 YOU SO MUCH FOR THE SUPPORT OF 1734 01:05:23,235 --> 01:05:24,503 THE COUNCILMEMBERS. 1735 01:05:24,503 --> 01:05:25,637 I'LL JUST SAY, IN THE FUTURE 1736 01:05:25,637 --> 01:05:26,805 ANYTHING I CAN BE HELPFUL JU 1737 01:05:26,805 --> 01:05:37,216 CALL ME AND I'LL DO IT. 1738 01:05:45,157 --> 01:05:46,625 >> CYNTHIA HULING-HUMMEL. 1739 01:05:46,625 --> 01:05:47,826 THIS IS LIKE SAYING GOODBYE TO 1740 01:05:47,826 --> 01:05:48,160 FAMILY. 1741 01:05:48,160 --> 01:05:54,233 IT REFLECTS HOW TIME FLIES. 1742 01:05:54,233 --> 01:05:57,469 >.I HAD THE PRIVILEGE OF WORKING 1743 01:05:57,469 --> 01:06:04,576 WITH CYNTHIA ON THE NATIONAL 1744 01:06:04,576 --> 01:06:05,844 ALZHEIMER'S COUNCIL. 1745 01:06:05,844 --> 01:06:07,913 YOUR WISDOM AND HUMANITY YOU 1746 01:06:07,913 --> 01:06:08,881 BROUGHT TO ALL OF THIS, 1747 01:06:08,881 --> 01:06:10,115 COMMITMENT AND DEDICATION HAVE 1748 01:06:10,115 --> 01:06:11,517 BEEN INSPIRATIONAL TO ALL OF US, 1749 01:06:11,517 --> 01:06:12,818 AND WE'D LOVE TO HEAR FROM YOU 1750 01:06:12,818 --> 01:06:13,252 ONCE AGAIN. 1751 01:06:13,252 --> 01:06:14,987 >> ALL RIGHT, THANK YOU. 1752 01:06:14,987 --> 01:06:17,956 WELL, I ATTENDED MY FIRST NACA 1753 01:06:17,956 --> 01:06:19,691 MEETING ON TUESDAY, 1754 01:06:19,691 --> 01:06:20,125 JANUARY 12TH, 2021. 1755 01:06:20,125 --> 01:06:21,093 I LOOKED IT UP. 1756 01:06:21,093 --> 01:06:23,262 I ZOOMED IN ON MY CELL PHONE 1757 01:06:23,262 --> 01:06:25,831 FROM THE BACK SEAT OF AN UBER AS 1758 01:06:25,831 --> 01:06:29,268 I TRAVELED FROM MY HOME IN 1759 01:06:29,268 --> 01:06:31,436 ELMIRA TO STRONG HOSPITAL IN 1760 01:06:31,436 --> 01:06:32,204 ROCHESTER, NEW YORK. 1761 01:06:32,204 --> 01:06:34,606 I STAYED ON THE CALL AS I WAS 1762 01:06:34,606 --> 01:06:35,908 TRANSPORTED TO A WHEELCHAIR, AND 1763 01:06:35,908 --> 01:06:37,943 THEN MOVED TO A GURNEY. 1764 01:06:37,943 --> 01:06:40,145 I ANSWERED ROLL CALL AS I 1765 01:06:40,145 --> 01:06:41,346 LISTENED TO THE PROCEEDINGS AND 1766 01:06:41,346 --> 01:06:43,849 I WAITED TO BE TAKEN IN TO HAVE 1767 01:06:43,849 --> 01:06:46,351 A BLOOD PATCH TO STOP THE 1768 01:06:46,351 --> 01:06:47,452 TERRIBLE HEADACHES THAT WERE 1769 01:06:47,452 --> 01:06:51,690 CAUSED BY MY LEAKING 1770 01:06:51,690 --> 01:06:52,124 CEREBROSPINAL FLUID. 1771 01:06:52,124 --> 01:06:53,992 MY BAD. 1772 01:06:53,992 --> 01:06:56,161 I HADN'T HEEDED MY DOCTOR'S 1773 01:06:56,161 --> 01:06:57,996 ADVICE AFTER A SPINAL TAP FOR 1774 01:06:57,996 --> 01:07:00,832 THE ADNI STUDY TO TAKE IT EASY, 1775 01:07:00,832 --> 01:07:02,367 AND I PAID THE PRICE AND I 1776 01:07:02,367 --> 01:07:04,203 STAYED ON THAT NACA ZOOM CALL 1777 01:07:04,203 --> 01:07:05,537 FOR AS LONG AS I COULD UNTIL I 1778 01:07:05,537 --> 01:07:07,639 WAS WHEELED INTO THE PROCEDURE 1779 01:07:07,639 --> 01:07:08,040 ROOM. 1780 01:07:08,040 --> 01:07:10,776 I HAVE TO CONFESS, I HAVE NO 1781 01:07:10,776 --> 01:07:12,744 IDEA WHAT WAS DISCUSSED THAT 1782 01:07:12,744 --> 01:07:13,946 DAY. 1783 01:07:13,946 --> 01:07:16,114 SO MUCH OF IT WAS ALPHABET SOUP 1784 01:07:16,114 --> 01:07:18,817 AND SO FAR OVER MY HEAD, I CAN 1785 01:07:18,817 --> 01:07:19,718 HONESTLY SAY, THOUGH, THAT IT 1786 01:07:19,718 --> 01:07:22,421 WAS A MEMORABLE START TO A 1787 01:07:22,421 --> 01:07:24,056 MEMORABLE FOUR YEARS ON NACA. 1788 01:07:24,056 --> 01:07:26,024 AND IT HAS BEEN AN HONOR TO 1789 01:07:26,024 --> 01:07:27,359 SERVE WITH ALL OF YOU. 1790 01:07:27,359 --> 01:07:29,294 I HAVE SO APPRECIATED YOUR 1791 01:07:29,294 --> 01:07:31,697 WISDOM AND INSIGHTS AS WE HAVE 1792 01:07:31,697 --> 01:07:34,099 CONSIDERED VARIOUS FUNDING 1793 01:07:34,099 --> 01:07:34,866 OPPORTUNITIES. 1794 01:07:34,866 --> 01:07:36,935 PERHAPS EVEN MORE IMPORTANTLY, 1795 01:07:36,935 --> 01:07:39,238 THOUGH, I HAVE APPRECIATED 1796 01:07:39,238 --> 01:07:40,772 HEARING YOUR INSIGHTS, YOUR 1797 01:07:40,772 --> 01:07:42,841 PERSONAL STORIES, WHEN YOU SPOKE 1798 01:07:42,841 --> 01:07:47,312 TO ME OVER BREAKS AND OVER LUNCH 1799 01:07:47,312 --> 01:07:48,847 ABOUT A PARENT, A COLLEAGUE, A 1800 01:07:48,847 --> 01:07:51,149 NEIGHBOR, LIVING WITH 1801 01:07:51,149 --> 01:07:53,318 ALZHEIMER'S DISEASE, AND HOW 1802 01:07:53,318 --> 01:07:54,353 THOSE HEART-WRENCHING 1803 01:07:54,353 --> 01:07:55,053 EXPERIENCES HAVE SHAPED YOUR 1804 01:07:55,053 --> 01:07:58,457 LIFE AND YOUR INTEREST AND YOUR 1805 01:07:58,457 --> 01:08:00,092 PASSION IN DEMENTIA RESEARCH. 1806 01:08:00,092 --> 01:08:02,294 AND YOU'VE BROUGHT THAT TO THIS 1807 01:08:02,294 --> 01:08:04,029 VERY TABLE, LENDING YOUR VOICE 1808 01:08:04,029 --> 01:08:07,599 TO THIS IMPORTANT WORK, AND I 1809 01:08:07,599 --> 01:08:08,767 WANT TO THANK EACH AND EVERY ONE 1810 01:08:08,767 --> 01:08:10,135 OF YOU FOR SHARING YOUR 1811 01:08:10,135 --> 01:08:12,404 EXPERTISE AND YOUR IDEAS. 1812 01:08:12,404 --> 01:08:14,072 SO I AM A PREACHER AND I CAN'T 1813 01:08:14,072 --> 01:08:15,774 RESIST SHARING A FEW OF MY 1814 01:08:15,774 --> 01:08:17,509 REFLECTIONS AND HOPES WITH YOU 1815 01:08:17,509 --> 01:08:19,278 ALL, BUT I PROMISE TO KEEP MY 1816 01:08:19,278 --> 01:08:24,750 SERMON SHORT. 1817 01:08:24,750 --> 01:08:28,120 WHEN DR. HODES REACHED OUT TO ME 1818 01:08:28,120 --> 01:08:30,088 ABOUT SERVING ON NACA, I WAS 1819 01:08:30,088 --> 01:08:31,290 HONORED TO BE CONSIDERED FOR 1820 01:08:31,290 --> 01:08:32,124 THIS IMPORTANT ROLE AS THE FIRST 1821 01:08:32,124 --> 01:08:34,559 PERSON WITH A DIAGNOSIS TO SERVE 1822 01:08:34,559 --> 01:08:35,994 ON NACA AND TO HAVE BROUGHT MY 1823 01:08:35,994 --> 01:08:36,762 LIVED EXPERIENCE TO THIS TABLE. 1824 01:08:36,762 --> 01:08:37,929 AND I WOULD URGE YOU, MY 1825 01:08:37,929 --> 01:08:40,565 FRIENDS, TO MAKE SURE THAT YOUR 1826 01:08:40,565 --> 01:08:42,401 INSTITUTION HAS A RESEARCH 1827 01:08:42,401 --> 01:08:44,169 ADVISORY BOARD, WHERE WE, PEOPLE 1828 01:08:44,169 --> 01:08:45,570 LIVING WITH ALZHEIMER'S AND 1829 01:08:45,570 --> 01:08:47,439 OTHER DEMENTIAS, AS WELL AS OUR 1830 01:08:47,439 --> 01:08:50,142 CARE PARTNERS, SHARE OUR WISDOM 1831 01:08:50,142 --> 01:08:52,444 AND OUR EXPERTISE, BECAUSE WE 1832 01:08:52,444 --> 01:08:55,080 ARE THE EXPERTS, AND WE'RE IN 1833 01:08:55,080 --> 01:08:57,582 THIS TOGETHER. 1834 01:08:57,582 --> 01:08:59,084 I NEVER ENVISIONED PARTICIPATING 1835 01:08:59,084 --> 01:08:59,751 IN ALZHEIMER'S RESEARCH. 1836 01:08:59,751 --> 01:09:03,121 IT WASN'T ON MY RADAR. 1837 01:09:03,121 --> 01:09:05,190 I WAS BUSY PASTORING AN ACTIVE 1838 01:09:05,190 --> 01:09:07,492 CHURCH IN LIONS, NEW YORK. 1839 01:09:07,492 --> 01:09:09,461 I WAS SINGING IN A ROCK AND ROLL 1840 01:09:09,461 --> 01:09:11,196 COUNTRY BAND AND WORKING ON MY 1841 01:09:11,196 --> 01:09:11,863 DOCTORATE IN MINISTRY. 1842 01:09:11,863 --> 01:09:12,831 THAT'S WHEN I STARTED 1843 01:09:12,831 --> 01:09:14,466 EXPERIENCING SYMPTOMS OF MEMORY 1844 01:09:14,466 --> 01:09:15,567 LOSS. 1845 01:09:15,567 --> 01:09:16,968 MY MOTHER CLAIRE DIED WITH 1846 01:09:16,968 --> 01:09:18,170 ALZHEIMER'S AND SO DID HER 1847 01:09:18,170 --> 01:09:19,705 BROTHER AUSTIN. 1848 01:09:19,705 --> 01:09:21,840 MY MATERNAL GRANDMOTHER, MIMI, 1849 01:09:21,840 --> 01:09:25,677 DIED WITH SOME SORT OF DEMENTIA. 1850 01:09:25,677 --> 01:09:29,381 AND I JOINED ADNI IN 2010. 1851 01:09:29,381 --> 01:09:30,315 PARTICIPATING IN RESEARCH HAS 1852 01:09:30,315 --> 01:09:31,583 BEEN LIFE CHANGING FOR ME AND IT 1853 01:09:31,583 --> 01:09:36,154 GAVE ME PURPOSE AFTER I WAS 1854 01:09:36,154 --> 01:09:44,129 DIAGNOSED WITH A -- I CARRIED TO 1855 01:09:44,129 --> 01:09:47,399 COPIES SO MY DIAGNOSIS WASN'T A 1856 01:09:47,399 --> 01:09:48,834 SURPRISE BUT IT WAS A SADNESS. 1857 01:09:48,834 --> 01:09:52,771 BUT BY PARTICIPATING IN RESEARCH 1858 01:09:52,771 --> 01:09:54,906 I HONOR THE MEMORIES OF MY 1859 01:09:54,906 --> 01:09:55,707 FAMILY. 1860 01:09:55,707 --> 01:09:57,109 AND I FURTHERED SCIENCE. 1861 01:09:57,109 --> 01:09:59,077 BUT I HAD ANOTHER MOTIVE FOR 1862 01:09:59,077 --> 01:10:00,479 JOINING AN ALZHEIMER'S RESEARCH 1863 01:10:00,479 --> 01:10:01,880 STUDY AND THAT WAS AND CONTINUES 1864 01:10:01,880 --> 01:10:04,216 TO BE TO LEARN MORE ABOUT MY OWN 1865 01:10:04,216 --> 01:10:05,817 BRAIN HEALTH AS I PLAN FOR 1866 01:10:05,817 --> 01:10:06,585 WHAT'S AHEAD. 1867 01:10:06,585 --> 01:10:07,786 IT'S BEEN FRUSTRATING TO NOT 1868 01:10:07,786 --> 01:10:09,354 HAVE ACCESS TO MY PERSONAL DATA, 1869 01:10:09,354 --> 01:10:11,089 MY PERSONAL RESULTS, AND I ADMIT 1870 01:10:11,089 --> 01:10:12,557 I'VE BEEN A SQUEAKY WHEEL ON 1871 01:10:12,557 --> 01:10:13,158 THIS SUBJECT. 1872 01:10:13,158 --> 01:10:14,793 AND LAST YEAR A GROUP OF US, 1873 01:10:14,793 --> 01:10:19,631 COLLEAGUES FROM ACTC AND AGREED, 1874 01:10:19,631 --> 01:10:22,434 WE PUBLISHED A RESEARCH 1875 01:10:22,434 --> 01:10:23,135 PARTICIPANTS BILL OF RIGHTS IN 1876 01:10:23,135 --> 01:10:23,869 THE JOURNAL OF ALZHEIMER'S 1877 01:10:23,869 --> 01:10:24,936 DISEASE AND AS A RESULT OF OUR 1878 01:10:24,936 --> 01:10:26,471 NUDGING, THIS YEAR, FOR THE VERY 1879 01:10:26,471 --> 01:10:29,207 FIRST TIME, RESULTS OF BETA 1880 01:10:29,207 --> 01:10:30,308 AMYLOID PET SCANS WILL BE SHARED 1881 01:10:30,308 --> 01:10:33,044 WITH THOSE OF US WHO WERE IN 1882 01:10:33,044 --> 01:10:34,279 ADNI, AND IT BEEN A LONG TIME 1883 01:10:34,279 --> 01:10:35,013 COMING. 1884 01:10:35,013 --> 01:10:38,483 SO I ASK YOU, MY COLLEAGUES, TO 1885 01:10:38,483 --> 01:10:40,285 THE EXTENT THAT YOU'RE ABLE TO 1886 01:10:40,285 --> 01:10:43,455 SHAPE YOUR RESEARCH PROPOSALS AT 1887 01:10:43,455 --> 01:10:47,592 YOUR INSTITUTION TO ADOPT THE 1888 01:10:47,592 --> 01:10:48,193 RESEARCH PARTICIPANTS' BILL OF 1889 01:10:48,193 --> 01:10:49,027 RIGHTS AT YOUR INSTITUTION, AND 1890 01:10:49,027 --> 01:10:51,196 TO BUILD IN THE RETURN OF 1891 01:10:51,196 --> 01:10:52,531 PERSONAL RESEARCH RESULTS TO 1892 01:10:52,531 --> 01:10:54,433 RESEARCH PARTICIPANTS. 1893 01:10:54,433 --> 01:10:55,934 PLAN THAT IN YOUR FUNDING AND IN 1894 01:10:55,934 --> 01:10:57,135 YOUR STUDY. 1895 01:10:57,135 --> 01:10:58,336 JUST DO IT. 1896 01:10:58,336 --> 01:11:03,041 PERIOD. 1897 01:11:03,041 --> 01:11:05,710 I REALIZE SOME RESEARCH 1898 01:11:05,710 --> 01:11:06,411 PARTICIPANTS MAY NOT WANT TO 1899 01:11:06,411 --> 01:11:07,779 KNOW, BUT MANY OF US DO. 1900 01:11:07,779 --> 01:11:08,880 TO THE EXTENT THAT YOU'RE ABLE 1901 01:11:08,880 --> 01:11:10,415 TO INFLUENCE YOUR INSTITUTION, 1902 01:11:10,415 --> 01:11:11,516 EXPAND YOUR RESEARCH TO INCLUDE 1903 01:11:11,516 --> 01:11:12,918 RATHER THAN RULE OUT PERSONS 1904 01:11:12,918 --> 01:11:15,220 WITH COMORBIDITIES, BECAUSE THE 1905 01:11:15,220 --> 01:11:17,923 REALITY IS MOST OF US DO HAVE 1906 01:11:17,923 --> 01:11:19,124 COMORBIDITIES, AND WE NEED THAT 1907 01:11:19,124 --> 01:11:21,860 DATA TO SEE IF TREATMENTS AND 1908 01:11:21,860 --> 01:11:23,829 INTERVENTIONS WORK IN VARIOUS 1909 01:11:23,829 --> 01:11:24,262 POPULATIONS. 1910 01:11:24,262 --> 01:11:25,697 WE'VE HEARD THE REASONS WHY IT'S 1911 01:11:25,697 --> 01:11:27,866 SO DIFFICULT TO INCLUDE PEOPLE 1912 01:11:27,866 --> 01:11:31,570 WITH COMORBIDITIES, AS THERE ARE 1913 01:11:31,570 --> 01:11:32,437 SO MANY VARIABLES. 1914 01:11:32,437 --> 01:11:34,072 AND I'VE HEARD STORIES OF PEOPLE 1915 01:11:34,072 --> 01:11:35,273 WHO EXCLUDED FROM ALZHEIMER'S 1916 01:11:35,273 --> 01:11:36,908 RESEARCH STUDY BECAUSE OF A 1917 01:11:36,908 --> 01:11:39,744 COMMON MEDICAL CONDITION SUCH AS 1918 01:11:39,744 --> 01:11:41,079 DIABETES OR HIGH BLOOD PRESSURE. 1919 01:11:41,079 --> 01:11:42,581 BUT HERE'S THE THING. 1920 01:11:42,581 --> 01:11:44,649 IF WE'RE NOT INCLUDED IN YOUR 1921 01:11:44,649 --> 01:11:49,020 STUDIES, WE WON'T KNOW IF A 1922 01:11:49,020 --> 01:11:50,222 PROPOSED TREATMENT OR 1923 01:11:50,222 --> 01:11:51,289 INTERVENTION WILL WORK IN THAT 1924 01:11:51,289 --> 01:11:52,057 POPULATION SO WE NEED TO 1925 01:11:52,057 --> 01:11:53,892 CONTINUE TO EXPAND RESEARCH AND 1926 01:11:53,892 --> 01:11:55,660 ENSURE THAT RESEARCHERS AND 1927 01:11:55,660 --> 01:11:56,595 RESEARCH PARTICIPANTS REFLECT 1928 01:11:56,595 --> 01:11:58,396 THE FULL AND THE WONDERFUL 1929 01:11:58,396 --> 01:12:01,967 DIVERSITY OF OUR NATION. 1930 01:12:01,967 --> 01:12:03,568 DON'T EXPECT PEOPLE TO TRAVEL TO 1931 01:12:03,568 --> 01:12:04,236 YOUR INSTITUTION ACCORDING TO 1932 01:12:04,236 --> 01:12:05,337 YOUR SCHEDULES, ONE THAT WORKS 1933 01:12:05,337 --> 01:12:08,940 FOR YOU AND YOUR RESEARCH TEAM. 1934 01:12:08,940 --> 01:12:10,208 BRING YOUR RESEARCH TO THE 1935 01:12:10,208 --> 01:12:11,209 PEOPLE AND MAKE IT EASY FOR 1936 01:12:11,209 --> 01:12:12,210 PEOPLE TO PARTICIPATE. 1937 01:12:12,210 --> 01:12:16,314 LOOK FOR WAYS TO INCENTIVIZE 1938 01:12:16,314 --> 01:12:17,182 YOUR RESEARCH. 1939 01:12:17,182 --> 01:12:18,483 DON'T THINK OF US AS PEOPLE TO 1940 01:12:18,483 --> 01:12:22,320 BE STUDIED BUT AS PARTNERS IN 1941 01:12:22,320 --> 01:12:22,754 RESEARCH. 1942 01:12:22,754 --> 01:12:24,155 IF WE HAVE A POSITIVE EXPERIENCE 1943 01:12:24,155 --> 01:12:26,024 IN YOUR STUDY, WE MAY BE ABLE TO 1944 01:12:26,024 --> 01:12:29,027 BE OPEN TO BEING RESEARCH 1945 01:12:29,027 --> 01:12:30,128 AMBASSADORS, RECRUITING OTHERS 1946 01:12:30,128 --> 01:12:31,029 FROM OUR COMMUNITIES, BUT IF WE 1947 01:12:31,029 --> 01:12:33,765 DON'T HAVE A GOOD EXPERIENCE IN 1948 01:12:33,765 --> 01:12:35,233 YOUR RESEARCH, YOU MAY HAVE A 1949 01:12:35,233 --> 01:12:37,202 HARDER TIME MEETING YOUR DEI 1950 01:12:37,202 --> 01:12:38,336 GOAL. 1951 01:12:38,336 --> 01:12:40,272 I'M ALWAYS RECEIVING 1952 01:12:40,272 --> 01:12:41,006 INVITATIONS. 1953 01:12:41,006 --> 01:12:42,874 ESPECIALLY ON SOCIAL MEDIA 1954 01:12:42,874 --> 01:12:44,276 RECENTLY, FOR PEOPLE LIVING WITH 1955 01:12:44,276 --> 01:12:45,911 DEMENTIA AND CARE PARTNERS TO 1956 01:12:45,911 --> 01:12:49,080 PARTICIPATE IN RESEARCH, AND 1957 01:12:49,080 --> 01:12:50,782 I'VE CALLED TO GET MORE RESEARCH 1958 01:12:50,782 --> 01:12:52,117 ON SOME OF THEM AND I'VE BEEN 1959 01:12:52,117 --> 01:12:53,318 REJECTED BECAUSE I DON'T HAVE A 1960 01:12:53,318 --> 01:12:55,086 CARE PARTNER WHO LIVES WITH ME. 1961 01:12:55,086 --> 01:12:56,221 IT'S ESTIMATED THAT IN THE 1962 01:12:56,221 --> 01:12:57,122 UNITED STATES, ONE-THIRD OF THE 1963 01:12:57,122 --> 01:12:59,391 PEOPLE WITH DEMENTIA LIVE ALONE. 1964 01:12:59,391 --> 01:13:02,260 STATED ANOTHER WAY, AT LEAST 1965 01:13:02,260 --> 01:13:03,528 1 IN 7 INDIVIDUALS LIVING WITH 1966 01:13:03,528 --> 01:13:07,799 DEMENTIA LIVES ALONE, A TOTAL OF 1967 01:13:07,799 --> 01:13:09,568 800,000 PEOPLE, AND I'M ONE OF 1968 01:13:09,568 --> 01:13:09,968 THEM. 1969 01:13:09,968 --> 01:13:11,937 I DON'T WANT ANYONE'S PITY, I'M 1970 01:13:11,937 --> 01:13:13,238 QUITE CONTENT IN MY LIVING 1971 01:13:13,238 --> 01:13:14,005 ARRANGEMENTS, BUT HERE'S THE 1972 01:13:14,005 --> 01:13:15,407 THING, I'VE BEEN TURNED AWAY TBR 1973 01:13:15,407 --> 01:13:17,242 SERVICES AND PROGRAMS ALSO FOR 1974 01:13:17,242 --> 01:13:18,610 PEOPLE LIVING WITH DEMENTIA 1975 01:13:18,610 --> 01:13:19,945 BECAUSE I DON'T HAVE A CARE 1976 01:13:19,945 --> 01:13:23,114 PARTNER TO ACCOMPANY ME. 1977 01:13:23,114 --> 01:13:25,417 I'VE ALSO BEEN TOLD I CAN'T 1978 01:13:25,417 --> 01:13:26,351 PARTICIPATE IN SOME PROJECTS 1979 01:13:26,351 --> 01:13:27,452 BECAUSE I HAVE NO INFORMANT. 1980 01:13:27,452 --> 01:13:31,289 OH, I HATE THAT WORD. 1981 01:13:31,289 --> 01:13:31,523 LIVE-IN. 1982 01:13:31,523 --> 01:13:33,992 SO I INVITE YOU, MY COLLEAGUES, 1983 01:13:33,992 --> 01:13:35,327 IN RESEARCH TO CONSIDER NOVEL 1984 01:13:35,327 --> 01:13:36,728 APPROACHES TO FUNDING, AND TO 1985 01:13:36,728 --> 01:13:38,897 SUPPORT THOSE OF US WHO ARE 1986 01:13:38,897 --> 01:13:39,998 MANAGING THIS DISEASE. 1987 01:13:39,998 --> 01:13:43,268 AND LIVING ALONE. 1988 01:13:43,268 --> 01:13:45,537 I MAY BE ENDING MY TERM ON NACA, 1989 01:13:45,537 --> 01:13:47,505 BUT I AM NOT DONE ADVOCATING FOR 1990 01:13:47,505 --> 01:13:49,040 THOSE AFFECTED BY ALZHEIMER'S 1991 01:13:49,040 --> 01:13:49,808 AND RELATED DEMENTIAS. 1992 01:13:49,808 --> 01:13:51,309 IN FACT, I'LL BE BACK HERE NEXT 1993 01:13:51,309 --> 01:13:53,478 WEEK FOR THE RESEARCH SUMMIT ON 1994 01:13:53,478 --> 01:13:56,681 A PANEL ADDRESSING PARTICIPANTS 1995 01:13:56,681 --> 01:13:57,949 AS DIRECT PARTNERS IN RESEARCH 1996 01:13:57,949 --> 01:14:00,986 AND I INVITE YOU TO ZOOM IN, 1997 01:14:00,986 --> 01:14:02,220 THOSE WHO MIGHT BE ABLE TO JOIN 1998 01:14:02,220 --> 01:14:03,421 US IN PERSON. 1999 01:14:03,421 --> 01:14:05,657 AS I CLOSE, I WANT TO GIVE A 2000 01:14:05,657 --> 01:14:07,759 SPECIAL SHOUT OUT TO YOU, 2001 01:14:07,759 --> 01:14:08,827 DR. HODES, FOR BELIEVING IN ME. 2002 01:14:08,827 --> 01:14:11,429 THANK YOU. 2003 01:14:11,429 --> 01:14:15,967 TO KEN, SUCH, JASMINE WHEREVER 2004 01:14:15,967 --> 01:14:18,003 SHE IS, AND ALL OF YOU, THANK 2005 01:14:18,003 --> 01:14:19,270 YOU ALL FOR DRAWING US TOGETHER. 2006 01:14:19,270 --> 01:14:21,473 IT HAS BEEN AN AMAZING 2007 01:14:21,473 --> 01:14:22,240 EXPERIENCE. 2008 01:14:22,240 --> 01:14:25,076 AND I KNOW YOU WILL GIVE A WARM 2009 01:14:25,076 --> 01:14:27,112 WELCOME TO MY SUCCESSOR, A 2010 01:14:27,112 --> 01:14:30,515 PERSON LIKE MYSELF, WITH A LIVED 2011 01:14:30,515 --> 01:14:31,182 EXPERIENCE OF ALZHEIMER'S 2012 01:14:31,182 --> 01:14:31,616 DISEASE. 2013 01:14:31,616 --> 01:14:41,793 THANK YOU. 2014 01:14:43,495 --> 01:14:45,897 >> WELL, THANK YOU FOR INSPIRING 2015 01:14:45,897 --> 01:14:49,401 US ALL AND REMINDING US ALL WHY 2016 01:14:49,401 --> 01:14:50,702 WE'RE DOING WHAT WE'RE DOING AND 2017 01:14:50,702 --> 01:15:01,179 HOW WE CAN DO IT BETTER YET. 2018 01:15:29,574 --> 01:15:31,476 NEXT WE'LL TURN TO DAVID REUBEN, 2019 01:15:31,476 --> 01:15:33,111 WHO ALSO HAS SHARED HIS WISDOM 2020 01:15:33,111 --> 01:15:36,915 AND EXPERTISE, AND A PARTICULAR 2021 01:15:36,915 --> 01:15:38,450 INSISTENCE THAT WE PAY ATTENTION 2022 01:15:38,450 --> 01:15:43,021 TO THE REAL WORLD ISSUES THAT WE 2023 01:15:43,021 --> 01:15:44,989 ADDRESS, AND AN IMPORTANT AND 2024 01:15:44,989 --> 01:15:46,524 REFRESHING REFUSAL TO BE BOUND 2025 01:15:46,524 --> 01:15:47,692 BY APPARENT RULES AND 2026 01:15:47,692 --> 01:15:48,460 REGULATIONS WHEN THERE JUST 2027 01:15:48,460 --> 01:15:49,794 MIGHT BE A WAY TO DO THINGS 2028 01:15:49,794 --> 01:15:51,963 BETTER AND MORE EFFECTIVELY. 2029 01:15:51,963 --> 01:15:53,898 WE'LL MISS BOTH THE SUBJECT 2030 01:15:53,898 --> 01:15:58,269 MATTER EXPERTISE AND THE 2031 01:15:58,269 --> 01:16:06,344 ASSERTIVE IF NEED BE 2032 01:16:06,344 --> 01:16:07,212 ICONOCLASTIC APPROACH FOR DOING 2033 01:16:07,212 --> 01:16:08,847 WHAT NEEDS TO BE DONE AND THANK 2034 01:16:08,847 --> 01:16:11,116 YOU FOR SERVING US IN ALL THESE 2035 01:16:11,116 --> 01:16:11,349 ASPECTS. 2036 01:16:11,349 --> 01:16:13,518 >> LET ME JUST SAY, FIRST OF 2037 01:16:13,518 --> 01:16:14,719 ALL, IT'S VERY DIFFICULT TO 2038 01:16:14,719 --> 01:16:15,353 FOLLOW CYNTHIA. 2039 01:16:15,353 --> 01:16:16,755 YOU NEVER WANT TO BE IN THAT 2040 01:16:16,755 --> 01:16:17,188 POSITION. 2041 01:16:17,188 --> 01:16:18,623 IT TRULY HAS BEEN AN HONOR TO 2042 01:16:18,623 --> 01:16:22,260 WORK ON NACA, AND MOSTLY BECAUSE 2043 01:16:22,260 --> 01:16:24,963 TO SEE THE INNER WORKINGS OF 2044 01:16:24,963 --> 01:16:25,563 NIA. 2045 01:16:25,563 --> 01:16:26,498 AND I'VE DEVELOPED SUCH RESPECT 2046 01:16:26,498 --> 01:16:30,301 FOR THE PROCESSES, AS WELL AS 2047 01:16:30,301 --> 01:16:31,136 THE PEOPLE. 2048 01:16:31,136 --> 01:16:32,670 THIS IS A REALLY GOOD CULTURE 2049 01:16:32,670 --> 01:16:34,572 HERE. 2050 01:16:34,572 --> 01:16:36,474 AND THANK YOU, RICHARD, FOR 2051 01:16:36,474 --> 01:16:40,512 LEADING THAT CULTURE. 2052 01:16:40,512 --> 01:16:45,083 I THINK BACK WH TO WHEN I STARTD 2053 01:16:45,083 --> 01:16:47,619 ON NACA, OUR COHORT STARTED ON 2054 01:16:47,619 --> 01:16:54,058 NACA, THERE WAS THIS BIG PAN DID 2055 01:16:54,058 --> 01:16:55,693 PANDEMIC. 2056 01:16:55,693 --> 01:16:57,562 WE WERE ALL VIRTUAL, ALL SHUT 2057 01:16:57,562 --> 01:16:59,631 IN, AND AS BAD AS THINGS ARE, IN 2058 01:16:59,631 --> 01:17:01,466 MANY RESPECTS, THEY'RE SO MUCH 2059 01:17:01,466 --> 01:17:02,433 BETTER THAN THEY WERE THEN, SO 2060 01:17:02,433 --> 01:17:06,037 WE SHOULD BE GRATEFUL. 2061 01:17:06,037 --> 01:17:11,376 I HAVE TO THANK A FEW PEOPLE, 2062 01:17:11,376 --> 01:17:15,213 SPECIFICALLY SINOGE AND JASMINE 2063 01:17:15,213 --> 01:17:16,748 WHO HAVE BAILED ME OUT TOO MANY 2064 01:17:16,748 --> 01:17:18,082 TIMES TO COUNT, INCLUDING 2065 01:17:18,082 --> 01:17:18,516 YESTERDAY. 2066 01:17:18,516 --> 01:17:20,118 SO THANK YOU, GUYS, AND IT'S 2067 01:17:20,118 --> 01:17:22,687 BEEN AN HONOR, IT'S A PLEASURE, 2068 01:17:22,687 --> 01:17:24,455 AND YOU GUYS ARE DOING THE RIGHT 2069 01:17:24,455 --> 01:17:25,023 THING. 2070 01:17:25,023 --> 01:17:25,824 ANYBODY WHO SAYS ANYTHING BAD 2071 01:17:25,824 --> 01:17:27,058 ABOUT THE GOVERNMENT, THEY 2072 01:17:27,058 --> 01:17:33,598 SHOULD COME TO NIA. 2073 01:17:33,598 --> 01:17:43,775 THANK YOU. 2074 01:17:50,381 --> 01:17:51,883 >> AND JULIE, AGAIN, WITH 2075 01:17:51,883 --> 01:17:53,384 PROFOUND THANKS FOR ALL YOU'VE 2076 01:17:53,384 --> 01:17:54,252 BROUGHT TO OUR COUNCIL, THE 2077 01:17:54,252 --> 01:17:55,687 EXPERIENCE YOU'VE HAD IN 2078 01:17:55,687 --> 01:17:56,454 ALZHEIMER'S RESEARCH BUT NOT 2079 01:17:56,454 --> 01:17:59,157 LIMITED TO THATTER A OF 2080 01:17:59,157 --> 01:18:01,559 RESEARCH, FROM BASIC SCIENTIST 2081 01:18:01,559 --> 01:18:03,294 TRANSLATION INTO CLINICAL 2082 01:18:03,294 --> 01:18:05,163 ASPECTS AND THEIR IMPORTANCE, 2083 01:18:05,163 --> 01:18:06,564 AGAIN BOTH THE EXPERTISE, THE 2084 01:18:06,564 --> 01:18:07,465 COMMITMENT, PARTICIPATION AND 2085 01:18:07,465 --> 01:18:10,735 THE WISDOM OF THE GROUP HAVE 2086 01:18:10,735 --> 01:18:12,570 BEEN EXEMPLARY THESE PAST YEARS, 2087 01:18:12,570 --> 01:18:13,771 AND WE'LL MISS AND LOOK FORWARD 2088 01:18:13,771 --> 01:18:15,206 TO THE CHALLENGING TASK OF 2089 01:18:15,206 --> 01:18:17,075 FINDING SUCCESSORS WHO ARE 2090 01:18:17,075 --> 01:18:20,578 WORTHY OF THAT ROLE. 2091 01:18:20,578 --> 01:18:21,312 AND I TURN TO YOU. 2092 01:18:21,312 --> 01:18:22,513 >> THANK YOU SO MUCH. 2093 01:18:22,513 --> 01:18:26,251 AND LIKE MY PREDECESSORS, I 2094 01:18:26,251 --> 01:18:27,719 DON'T HAVE ANYTHING PREPARED AND 2095 01:18:27,719 --> 01:18:29,954 ONE OF THE REASONS IS THAT IT 2096 01:18:29,954 --> 01:18:31,489 CAME SO QUICKLY THAT I DIDN'T 2097 01:18:31,489 --> 01:18:38,162 KNOW I WAS GONE. 2098 01:18:38,162 --> 01:18:38,796 >> YOU'RE NOT. 2099 01:18:38,796 --> 01:18:42,500 >> BUT WE WERE STANDING WAITING 2100 01:18:42,500 --> 01:18:43,835 FOR THE VAN AND DAVID SAID, DO 2101 01:18:43,835 --> 01:18:46,104 YOU KNOW THAT WE'RE DONE, 2102 01:18:46,104 --> 01:18:46,871 THEY'RE ANNOUNCING WE'RE DONE? 2103 01:18:46,871 --> 01:18:48,273 I SAID, NO, REALLY? 2104 01:18:48,273 --> 01:18:49,774 AND APPARENTLY, PATRICIA DIDN'T 2105 01:18:49,774 --> 01:18:50,909 KNOW I WAS DONE EITHER BECAUSE 2106 01:18:50,909 --> 01:18:52,343 SHE THOUGHT I HAD ANOTHER YEAR. 2107 01:18:52,343 --> 01:18:53,645 BUT I THINK A LOT OF THIS HAS TO 2108 01:18:53,645 --> 01:18:55,580 DO WITH WHAT DAVID SAID AS WE 2109 01:18:55,580 --> 01:18:56,848 STARTED DURING THE PANDEMIC, AND 2110 01:18:56,848 --> 01:19:00,385 IT WAS A VERY DIFFICULT TIME FOR 2111 01:19:00,385 --> 01:19:01,853 ALL OF US AND DIFFICULT TO GET 2112 01:19:01,853 --> 01:19:04,322 TO KNOW EVERYBODY HERE. 2113 01:19:04,322 --> 01:19:06,291 SO I REALLY FEEL LIKE I'VE BEEN 2114 01:19:06,291 --> 01:19:08,026 ON FOR TWO YEARS, WHERE I'VE 2115 01:19:08,026 --> 01:19:09,661 GOTTEN TO KNOW EVERYBODY HERE SO 2116 01:19:09,661 --> 01:19:11,396 MUCH BETTER, AND I VALUE IT SO 2117 01:19:11,396 --> 01:19:11,863 MUCH. 2118 01:19:11,863 --> 01:19:16,301 AND I WANT TO ECHO WHAT OTHERS 2119 01:19:16,301 --> 01:19:21,572 HAD SAID, THAT I'VE LERCH LEARNO 2120 01:19:21,572 --> 01:19:23,207 MUCH ABOUT THE NIA AND HOW MUCH 2121 01:19:23,207 --> 01:19:24,509 EFFORT GOES TOWARDS DECIDING THE 2122 01:19:24,509 --> 01:19:25,810 RESEARCH THAT IS NEEDED FOR THE 2123 01:19:25,810 --> 01:19:27,245 FUTURE AND THE PRESENT AND HOW 2124 01:19:27,245 --> 01:19:30,848 BEST TO GO ABOUT IT, AND I HAVE 2125 01:19:30,848 --> 01:19:32,483 TO SAY COMING FROM AN MD WORLD 2126 01:19:32,483 --> 01:19:34,752 TOO, I HAD NO IDEA OF WHAT WAS 2127 01:19:34,752 --> 01:19:38,256 REALLY BEHIND RESEARCH, AND 2128 01:19:38,256 --> 01:19:41,659 WHO'S DIRECTING RESEARCH, AND TO 2129 01:19:41,659 --> 01:19:42,727 LEARN ABOUT ALL THIS IS REALLY 2130 01:19:42,727 --> 01:19:46,464 SPECIAL, REALLY SPECIAL, AND I 2131 01:19:46,464 --> 01:19:47,865 FEEL -- I WISH FOR ALL PEOPLE 2132 01:19:47,865 --> 01:19:49,267 WITHIN RESEARCH IN MEDICINE AND 2133 01:19:49,267 --> 01:19:52,670 SCIENCE, THAT THEY WOULD KNOW AS 2134 01:19:52,670 --> 01:19:55,173 MUCH AS THEY KNOW, AS AS I DO N, 2135 01:19:55,173 --> 01:19:56,574 ABOUT THE INNER WORKINGS. 2136 01:19:56,574 --> 01:19:58,209 ONE OF THE THINGS THAT I FEEL 2137 01:19:58,209 --> 01:19:59,010 PASSIONATE ABOUT AFTER LEARNING 2138 01:19:59,010 --> 01:20:05,984 ALL OF THIS IS THAT WE DO SHOW 2139 01:20:05,984 --> 01:20:08,720 PEOPLE WHAT IS THE NIH, OUR 2140 01:20:08,720 --> 01:20:10,688 STUDENTS, OUR UNDERGRADUATES, 2141 01:20:10,688 --> 01:20:11,789 OUR GRADUATE STUDENTS, OF HOW 2142 01:20:11,789 --> 01:20:15,927 MUCH THEY CAN BE A PART OF THIS 2143 01:20:15,927 --> 01:20:17,795 WONDERFUL COMMUNITY ON IMPARTING 2144 01:20:17,795 --> 01:20:21,833 BETTER HEALTH TO THE WORLD IN 2145 01:20:21,833 --> 01:20:22,166 SCIENCE. 2146 01:20:22,166 --> 01:20:23,468 SO I'M EXCITED ABOUT CONTINUING 2147 01:20:23,468 --> 01:20:26,304 THAT OPPORTUNITY FOR PEOPLE. 2148 01:20:26,304 --> 01:20:27,839 AND THANK YOU SO, SO MUCH FOR 2149 01:20:27,839 --> 01:20:29,474 INVITING ME AND GIVING ME THIS 2150 01:20:29,474 --> 01:20:30,008 HO MORE. 2151 01:20:30,008 --> 01:20:33,745 THISHONOR. 2152 01:20:33,745 --> 01:20:38,883 IT'S TRULY BEEN A PLEASURE, I'VE 2153 01:20:38,883 --> 01:20:40,184 ENJOYED EVERYBODY WHO'S BEHIND 2154 01:20:40,184 --> 01:20:41,953 THIS, RICHARD, PATRICIA FOR 2155 01:20:41,953 --> 01:20:43,388 BEING SUCH A GREAT SPORT WHEN I 2156 01:20:43,388 --> 01:20:45,656 WAS TERRIFIED ON BEING ON THE 2157 01:20:45,656 --> 01:20:47,392 TASK FORCE ON AGING. 2158 01:20:47,392 --> 01:20:57,668 THANK YOU AGAIN. 2159 01:21:01,472 --> 01:21:04,042 >> LET ME BRIEFLY RESPOND TO 2160 01:21:04,042 --> 01:21:06,210 JULIE AND INDEED ALL OF YOU. 2161 01:21:06,210 --> 01:21:08,646 ONE OF THE IMPORTANT ASPECTS OF 2162 01:21:08,646 --> 01:21:10,815 WORKING WITH ALL OF YOU, HAVING 2163 01:21:10,815 --> 01:21:11,916 THE PRIVILEGE TO WORK WITH ALL 2164 01:21:11,916 --> 01:21:14,619 OF YOU, IS HOW YOU FUNCTION AS A 2165 01:21:14,619 --> 01:21:15,753 GROUP IN CONCERT AND COMMUNITY 2166 01:21:15,753 --> 01:21:17,455 ALONG WITH US. 2167 01:21:17,455 --> 01:21:18,890 EVIDENT WHEN WE WERE UNABLE TO 2168 01:21:18,890 --> 01:21:20,758 MEET IN PERSON, AND A LOT OF 2169 01:21:20,758 --> 01:21:22,160 FOLKS GOT KIND OF COMFORTABLE 2170 01:21:22,160 --> 01:21:23,795 NOT HAVING TO MAKE A TRIP ACROSS 2171 01:21:23,795 --> 01:21:25,763 COUNTRY OR ACROSS DOWN. 2172 01:21:25,763 --> 01:21:27,498 IT'S MUCH EASIER NOT TO DO THAT, 2173 01:21:27,498 --> 01:21:29,033 BUT THE EXCITEMENT AND 2174 01:21:29,033 --> 01:21:30,134 ENTHUSIASM WITH WHICH YOU ALL 2175 01:21:30,134 --> 01:21:31,069 RESPONDED WHEN WE ASKED WHAT YOU 2176 01:21:31,069 --> 01:21:32,937 THOUGHT ABOUT COMING BACK IN 2177 01:21:32,937 --> 01:21:34,505 PERSON WAS REFLECTIVE, I THINK, 2178 01:21:34,505 --> 01:21:35,339 OF THE COMMITMENT IN THE 2179 01:21:35,339 --> 01:21:37,675 COMMUNITY THAT WE HAVE. 2180 01:21:37,675 --> 01:21:39,510 THOSE WHO AREN'T HERE TODAY 2181 01:21:39,510 --> 01:21:40,478 AREN'T BECAUSE OF VERY 2182 01:21:40,478 --> 01:21:41,679 COMPELLING REASONS OF VARIOUS 2183 01:21:41,679 --> 01:21:43,414 SORT, BUT IT'S BEEN AN ENORMOUS 2184 01:21:43,414 --> 01:21:44,515 REFLECTION ON THE QUALITY OF THE 2185 01:21:44,515 --> 01:21:47,018 GROUP AS THEY FUNCTION, AND TO 2186 01:21:47,018 --> 01:21:48,419 JULIE'S COMMENT AGAIN ABOUT 2187 01:21:48,419 --> 01:21:51,923 HAVING LEARNED ABOUT WHAT NIA IS 2188 01:21:51,923 --> 01:21:54,325 AND NIH IS AND HOW IT FUNCTIONS, 2189 01:21:54,325 --> 01:21:58,663 ALL OF YOU AMONG THE MANY ROLES 2190 01:21:58,663 --> 01:22:02,633 I'LL BE CALLING UPON YOU IN THE 2191 01:22:02,633 --> 01:22:03,835 FUTURE, BUT ALSO THE ROLE OF 2192 01:22:03,835 --> 01:22:05,236 BEING AMBASSADORS TO SHARE THIS 2193 01:22:05,236 --> 01:22:05,903 INFORMATION, AND MAYBE THE MOST 2194 01:22:05,903 --> 01:22:07,205 IMPORTANT ASPECT OF THAT IS TO 2195 01:22:07,205 --> 01:22:08,973 SHARE THE SINCERE INVITATION 2196 01:22:08,973 --> 01:22:11,609 THAT WE GIVE TO ALL OF THE 2197 01:22:11,609 --> 01:22:16,280 RESEARCH COMMUNITY OR ADVOCATES 2198 01:22:16,280 --> 01:22:17,815 TO WORK WITH US, THERE SHOULD BE 2199 01:22:17,815 --> 01:22:20,118 NO INTIM NATION, NO BARRIER, NO 2200 01:22:20,118 --> 01:22:21,219 CONCERN ABOUT WHAT IT MEANS TO 2201 01:22:21,219 --> 01:22:22,954 CALL US, IT'S NOT AN IMPOSITION, 2202 01:22:22,954 --> 01:22:24,388 IT'S WHAT WE'RE ABOUT AND IT'S 2203 01:22:24,388 --> 01:22:25,590 WHAT WE LIVE AND WORK FOR. 2204 01:22:25,590 --> 01:22:27,792 SO WHEN IN DOUBT, CONTACT 2205 01:22:27,792 --> 01:22:28,159 SOMEONE. 2206 01:22:28,159 --> 01:22:30,628 IF YOU DON'T KNOW WHO, CONTACT 2207 01:22:30,628 --> 01:22:33,698 ME, QUITE LITERALLY, AMY OR KEN, 2208 01:22:33,698 --> 01:22:35,533 ANYONE WHOSE NAME YOU REMEMBER, 2209 01:22:35,533 --> 01:22:37,835 USUALLY PRETTY EASY, FIRST NAME, 2210 01:22:37,835 --> 01:22:42,406 DOT, LAST NAME, DOT NIH DOT 2211 01:22:42,406 --> 01:22:42,840 GOFF. 2212 01:22:42,840 --> 01:22:44,108 THE MOST IMPORTANT ONE LINER WE 2213 01:22:44,108 --> 01:22:45,243 GIVE TO PEOPLE IS THAT PLEASE 2214 01:22:45,243 --> 01:22:46,043 REMEMBER THAT WE'RE WORKING WITH 2215 01:22:46,043 --> 01:22:48,646 YOU AND FOR YOU, AND DO NOT 2216 01:22:48,646 --> 01:22:51,382 HESITATE BUT RATHER BE EB 2217 01:22:51,382 --> 01:22:52,450 ENCOURAGED TO KEEP IN TOUCH WITH 2218 01:22:52,450 --> 01:22:52,917 US. 2219 01:22:52,917 --> 01:22:54,752 SO THANK YOU AS A GROUP AND A 2220 01:22:54,752 --> 01:22:55,953 COHORT, YOU'LL BE TOUGH TO BEAT, 2221 01:22:55,953 --> 01:22:57,488 BUT WE'LL DO OUR VERY BEST TO 2222 01:22:57,488 --> 01:22:59,023 MATCH WHAT YOU'VE COMMITTED AND 2223 01:22:59,023 --> 01:22:59,457 CONTRIBUTED TO US. 2224 01:22:59,457 --> 01:23:05,296 THANK YOU. 2225 01:23:05,296 --> 01:23:07,031 >> RICHARD, IF I MAKE TAKE A 2226 01:23:07,031 --> 01:23:09,100 POINT OF PRIVILEGE AND JUST TAKE 2227 01:23:09,100 --> 01:23:10,268 A SECOND TO ACKNOWLEDGE JULIE. 2228 01:23:10,268 --> 01:23:11,802 TO YOUR POINT ABOUT BEING 2229 01:23:11,802 --> 01:23:13,471 SLIGHTLY INTIMIDATED, I JUST 2230 01:23:13,471 --> 01:23:15,640 WANT TO PUBLICLY ACKNOWLEDGE, 2231 01:23:15,640 --> 01:23:18,209 THE TASK FORCE REALLY IS IN 2232 01:23:18,209 --> 01:23:19,710 SERVICE TO THE FULL COUNCIL, AND 2233 01:23:19,710 --> 01:23:21,112 I AM ENORMOUSLY GRATEFUL FOR THE 2234 01:23:21,112 --> 01:23:22,547 WISDOM AND EXPERTISE YOU BROUGHT 2235 01:23:22,547 --> 01:23:23,247 FORWARD. 2236 01:23:23,247 --> 01:23:26,584 YOU CAME IN, ARMS WIDE OPEN, AND 2237 01:23:26,584 --> 01:23:27,685 EMBRACED THE PROCESS AND JUST A 2238 01:23:27,685 --> 01:23:29,287 WORD TO THE WISE, ONE OF THE 2239 01:23:29,287 --> 01:23:31,055 THINGS THAT I LEARNED FROM YOU 2240 01:23:31,055 --> 01:23:32,423 IN OBSERVING YOUR LEADERSHIP 2241 01:23:32,423 --> 01:23:34,425 STYLE, YOU WERE VERY TRANSPARENT 2242 01:23:34,425 --> 01:23:36,627 IN ACKNOWLEDGING THIS IS NEW FOR 2243 01:23:36,627 --> 01:23:37,728 ME, AND HERE ARE THE THINGS THAT 2244 01:23:37,728 --> 01:23:39,463 I WOULD LEARN FROM MY TEAM AND 2245 01:23:39,463 --> 01:23:41,132 MY STAFF AT RUSH, AN THESE ARE 2246 01:23:41,132 --> 01:23:42,633 THE THINGS THAT WE CAN 2247 01:23:42,633 --> 01:23:43,935 INCORPORATE GOING FORWARD AS 2248 01:23:43,935 --> 01:23:45,469 WE'RE LOOKING AT HOW WE BUILD A 2249 01:23:45,469 --> 01:23:46,337 COMPELLING AGENDA AND 2250 01:23:46,337 --> 01:23:47,905 CONVERSATION. 2251 01:23:47,905 --> 01:23:48,539 FOR THE NEXT MEETING. 2252 01:23:48,539 --> 01:23:49,941 SO I APPRECIATE THAT 2253 01:23:49,941 --> 01:23:52,009 PERSPECTIVE, AND I JUST 2254 01:23:52,009 --> 01:23:53,211 ENCOURAGE EVERYONE, IF YOU SEE 2255 01:23:53,211 --> 01:23:56,714 ME COMING YOUR WAY, NOT TO RUN 2256 01:23:56,714 --> 01:24:00,318 IN FEAR, AND CHAT TO JULIE AND 2257 01:24:00,318 --> 01:24:03,387 SEE WHAT STRATEGY SHE USED TO 2258 01:24:03,387 --> 01:24:06,557 CONSIDER TAKING ON A YES TO 2259 01:24:06,557 --> 01:24:08,659 CHAIR THE TASK FORCE, BUT I 2260 01:24:08,659 --> 01:24:09,860 REALLY DO APPRECIATE YOUR 2261 01:24:09,860 --> 01:24:14,432 EXPERTISE AND THANK YOU. 2262 01:24:14,432 --> 01:24:17,401 >> THANK YOU SO MUCH. 2263 01:24:17,401 --> 01:24:18,703 I'M ACTUALLY SADDENED THAT I'M 2264 01:24:18,703 --> 01:24:20,037 GOING TO LEAVE BEFORE I GET AN 2265 01:24:20,037 --> 01:24:21,439 OPPORTUNITY TO HAVE ANOTHER 2266 01:24:21,439 --> 01:24:22,873 YEAR, BECAUSE I'VE BEEN LEARNING 2267 01:24:22,873 --> 01:24:26,244 SO MUCH, AND IT'S REALLY BEEN A 2268 01:24:26,244 --> 01:24:27,345 GREAT EXPERIENCE FOR ME AND I'M 2269 01:24:27,345 --> 01:24:29,814 GOING TO BRING THAT BACK TO MY 2270 01:24:29,814 --> 01:24:31,115 ALZHEIMER'S DISEASE RESEARCH 2271 01:24:31,115 --> 01:24:32,383 CENTER AND HOPEFULLY CONTINUE 2272 01:24:32,383 --> 01:24:34,151 THOSE CONVERSATIONS. 2273 01:24:34,151 --> 01:24:36,554 THANK YOU. 2274 01:24:36,554 --> 01:24:39,957 >> I'D ASK YOU ALL TO REMEMBER 2275 01:24:39,957 --> 01:24:41,692 THAT YOU'LL KNOW AND RECALL THE 2276 01:24:41,692 --> 01:24:43,427 PROCESS IS SOMETIMES ARDUOUS AND 2277 01:24:43,427 --> 01:24:44,395 COMPLEX IN BEING BROUGHT ON 2278 01:24:44,395 --> 01:24:45,162 BOARD TO COUNCIL. 2279 01:24:45,162 --> 01:24:46,464 THE SAME THING WILL HAPPEN TO 2280 01:24:46,464 --> 01:24:47,898 THE NEXT GROUP, WHICH MEANS THAT 2281 01:24:47,898 --> 01:24:50,401 THIS MAY NOT BE THE LAST TIME WE 2282 01:24:50,401 --> 01:24:51,168 SEE YOU. 2283 01:24:51,168 --> 01:24:54,772 SO PLEASE BE AS OPEN AS YOU HAVE 2284 01:24:54,772 --> 01:24:57,408 CLAIMED TO BE NOW TO CONTINUING 2285 01:24:57,408 --> 01:24:59,477 TO SERVE, IF WE CALL UPON YOU. 2286 01:24:59,477 --> 01:25:02,213 WE MAY WELL SEE YOU IN JANUARY, 2287 01:25:02,213 --> 01:25:03,614 REMEMBER JANUARY WILL BE REMOTE, 2288 01:25:03,614 --> 01:25:04,715 BUT ONE WAY OR ANOTHER, WE'LL 2289 01:25:04,715 --> 01:25:06,584 FIND WAYS TO CONTINUE THE 2290 01:25:06,584 --> 01:25:09,120 SERVICE. 2291 01:25:09,120 --> 01:25:11,622 >> AND THANK YOU ALL, TOO. 2292 01:25:11,622 --> 01:25:12,923 IT IS ALWAYS A PLEASURE WORKING 2293 01:25:12,923 --> 01:25:15,993 WITH EACH AND EVERY ONE OF YOU. 2294 01:25:15,993 --> 01:25:17,295 AND I GREATLY APPRECIATE ALL THE 2295 01:25:17,295 --> 01:25:22,199 TIME AND EFFORT YOU'VE HAD PUT 2296 01:25:22,199 --> 01:25:23,100 INTO THE COUNCIL, BECAUSE 2297 01:25:23,100 --> 01:25:25,836 BELIEVE ME, YOUR EXPERTISE, 2298 01:25:25,836 --> 01:25:28,472 KNOWLEDGE, INSIGHT, HAS BEEN 2299 01:25:28,472 --> 01:25:31,175 INCORPORATED IN EVERYTHING WE DO 2300 01:25:31,175 --> 01:25:33,044 AS AN INSTITUTE, SO YOUR LEGACY 2301 01:25:33,044 --> 01:25:34,779 MOVES ON AND AS RICHARD SAID, 2302 01:25:34,779 --> 01:25:36,314 YOU ARE OUR AMBASSADORS AND 2303 01:25:36,314 --> 01:25:38,282 ALWAYS WILL CONTINUE TO BE, SO 2304 01:25:38,282 --> 01:25:39,917 WE GREATLY APPRECIATE THAT. 2305 01:25:39,917 --> 01:25:44,422 SO THANK YOU. 2306 01:25:44,422 --> 01:25:48,359 SO WE WILL MOVE FORWARD NOW TO, 2307 01:25:48,359 --> 01:25:49,560 JULIE, I GUESS I'M GOING TO TURN 2308 01:25:49,560 --> 01:26:00,237 IT OVER TO YOU, YOU AND YA NEIRA 2309 01:26:00,805 --> 01:26:04,942 TO GIVE US THE REPORT ON THE 2310 01:26:04,942 --> 01:26:07,678 TASK FORCE ON MINORITY AGING. 2311 01:26:07,678 --> 01:26:10,014 >> I THINK YANIRA IS GOING TO 2312 01:26:10,014 --> 01:26:11,382 GET STARTED. 2313 01:26:11,382 --> 01:26:13,451 >> THANK YOU, DR. SCHNEIDER. 2314 01:26:13,451 --> 01:26:16,087 SO WE HAD A WONDERFUL LINEUP OF 2315 01:26:16,087 --> 01:26:16,654 SPEAKERS YESTERDAY MORNING. 2316 01:26:16,654 --> 01:26:20,257 WE STARTED WITH DR. GOODMAN'S 2317 01:26:20,257 --> 01:26:21,992 PRESENTATION WHICH CENTERED ON 2318 01:26:21,992 --> 01:26:23,194 DATA, DIVERSITY AND AGING. 2319 01:26:23,194 --> 01:26:25,062 HE HIGHLIGHTED THAT SYSTEMATIC 2320 01:26:25,062 --> 01:26:26,063 RACISM PERSISTS. 2321 01:26:26,063 --> 01:26:27,031 THE DATA SHOWS THAT WE HAVE A 2322 01:26:27,031 --> 01:26:30,534 PROBLEM WITH DISPARITIES, AND 2323 01:26:30,534 --> 01:26:32,503 THE DATA ITSELF HAS BEEN 2324 01:26:32,503 --> 01:26:33,137 CORRUPTED. 2325 01:26:33,137 --> 01:26:34,372 HE FURTHER INDICATED THAT OUR 2326 01:26:34,372 --> 01:26:39,844 LEGACY FOLLOWS US, RACISM ISN'T 2327 01:26:39,844 --> 01:26:41,145 IMPRINTED IN OUR DATASETS, BUT 2328 01:26:41,145 --> 01:26:42,880 WE NEED BIG DATASET TO GUIDE 2329 01:26:42,880 --> 01:26:43,881 PRACTICE, TO GUIDE RESEARCH AND 2330 01:26:43,881 --> 01:26:45,316 TO GUIDE POLICY. 2331 01:26:45,316 --> 01:26:47,718 FLAWCIAL AND TO TRAIN ARTIFICIAL 2332 01:26:47,718 --> 01:26:50,654 INTELLIGENCE SYSTEMS. 2333 01:26:50,654 --> 01:26:51,756 WE MUST, THEREFORE, WORK TO 2334 01:26:51,756 --> 01:26:53,357 ENSURE MORE ACCURATE AND 2335 01:26:53,357 --> 01:26:57,328 UNBIASED DATASETS. 2336 01:26:57,328 --> 01:26:59,397 WE MUST ALSO UNDERSTAND THE 2337 01:26:59,397 --> 01:27:03,834 UTILITY AND LIMITATIONS OFF UR R 2338 01:27:03,834 --> 01:27:04,268 COMPUTATIONAL TOOLS. 2339 01:27:04,268 --> 01:27:05,736 WE TALKED ABOUT RACISM IS WRONG 2340 01:27:05,736 --> 01:27:07,471 UNDER ANY MORAL ANALYSIS, AND WE 2341 01:27:07,471 --> 01:27:08,873 HAVE THE RESPONSIBILITY TO FIX 2342 01:27:08,873 --> 01:27:14,211 IT. 2343 01:27:14,211 --> 01:27:17,047 HE ALSO TALKED ABOUT -- HE 2344 01:27:17,047 --> 01:27:20,551 CALLED OUT RACISM AND AGEISM AND 2345 01:27:20,551 --> 01:27:22,520 PURSUING DIVERSITY, EQUITY AND 2346 01:27:22,520 --> 01:27:27,224 INCLUSION AS CIVIC DUTIES. 2347 01:27:27,224 --> 01:27:30,060 DATA AND ARTIFICIAL 2348 01:27:30,060 --> 01:27:32,563 INTELLIGENCE, DEI IS NOT WOKE. 2349 01:27:32,563 --> 01:27:37,868 IT IS AN UNDERTAKING, IT IS AN 2350 01:27:37,868 --> 01:27:40,137 UNDERTAKING TO MEET A BOLD FACE 2351 01:27:40,137 --> 01:27:41,005 MORAL OBLIGATION. 2352 01:27:41,005 --> 01:27:42,973 IN FIXING THIS PROBLEM, WE NEED 2353 01:27:42,973 --> 01:27:45,709 TO BE INTERDISCIPLINARY, WE ARE 2354 01:27:45,709 --> 01:27:47,344 BEST ABLE TO SUCCEED WHEN WE 2355 01:27:47,344 --> 01:27:49,079 KNOW WHAT OUR OTHER COLLEAGUES 2356 01:27:49,079 --> 01:27:50,514 ARE DOING. 2357 01:27:50,514 --> 01:27:54,452 WE ALSO NEED A MULTIPRONG 2358 01:27:54,452 --> 01:27:55,553 APPROACH. 2359 01:27:55,553 --> 01:27:57,087 HE CONCLUDED BY REITERATING THAT 2360 01:27:57,087 --> 01:27:58,923 THE DATA THAT WE HAVE IS BIASED, 2361 01:27:58,923 --> 01:28:01,158 AND THAT AS A CIVILIZED SOCIETY, 2362 01:28:01,158 --> 01:28:08,232 WE CANNOT TAKE THIS ANYMORE. 2363 01:28:08,232 --> 01:28:09,333 DR. SCHNEIDER, DO YOU WANT -- 2364 01:28:09,333 --> 01:28:11,402 WOULD YOU LIKE ME TO CONTINUE 2365 01:28:11,402 --> 01:28:13,370 WITH THE NEXT OR WOULD YOU LIKE 2366 01:28:13,370 --> 01:28:13,571 TO -- 2367 01:28:13,571 --> 01:28:15,239 >> I CAN MOVE TO OUR NEXT 2368 01:28:15,239 --> 01:28:15,673 SPEAKER. 2369 01:28:15,673 --> 01:28:24,982 OUR NEXT SPEAKER WAS LACHTMAN 2370 01:28:24,982 --> 01:28:25,850 TAMIL. 2371 01:28:25,850 --> 01:28:26,617 HE HAD COVID WHEN HE WAS 2372 01:28:26,617 --> 01:28:27,818 PRESENTING SO HE DID NOT FEEL 2373 01:28:27,818 --> 01:28:29,854 WELL DURING HIS SPEECH, BUT HE 2374 01:28:29,854 --> 01:28:31,989 IS A TENURED FULL PROFESSOR, I 2375 01:28:31,989 --> 01:28:33,824 SHOULD SAY, HE SPOKE ABOUT 2376 01:28:33,824 --> 01:28:36,026 BRIDGING THE GAP ADDRESSING 2377 01:28:36,026 --> 01:28:38,996 RACIAL BIAS IN ARTIFICIAL 2378 01:28:38,996 --> 01:28:39,730 INTELLIGENCE AND MACHINE 2379 01:28:39,730 --> 01:28:41,031 LEARNING FOR AGING POPULATIONS. 2380 01:28:41,031 --> 01:28:43,334 HE'S A TENURED FULL PROFESSOR OF 2381 01:28:43,334 --> 01:28:44,668 ELECTRICAL AND COMPUTER 2382 01:28:44,668 --> 01:28:45,436 ENGINEERING AT THE UNIVERSITY OF 2383 01:28:45,436 --> 01:28:45,769 TEXAS. 2384 01:28:45,769 --> 01:28:47,371 HE DIRECTS THE QUALITY OF LIFE 2385 01:28:47,371 --> 01:28:48,639 TECHNOLOGY LABORATORY, HAS A 2386 01:28:48,639 --> 01:28:50,574 PH.D. IN ELECTRICAL ENGINEERING, 2387 01:28:50,574 --> 01:28:53,010 MS IN MATH, AND HE HAS A 2388 01:28:53,010 --> 01:28:55,279 MASTER'S IN TECHNOLOGY IN 2389 01:28:55,279 --> 01:28:57,348 MICROWAVE AND OPTICAL 2390 01:28:57,348 --> 01:28:59,483 COMMUNICATIONS. 2391 01:28:59,483 --> 01:29:01,151 HIS RESEARCH EXPLORES ARTIFICIAL 2392 01:29:01,151 --> 01:29:02,620 INTELLIGENCE AND MACHINE 2393 01:29:02,620 --> 01:29:04,889 LEARNING, INCREASINGLY 2394 01:29:04,889 --> 01:29:07,958 INFLUENCING HEALTHCARE AND AGING 2395 01:29:07,958 --> 01:29:09,393 RESEARCH, AND DISCUSSED HOW IT'S 2396 01:29:09,393 --> 01:29:11,362 CRUCIAL TO ADDRESS THE RACIAL 2397 01:29:11,362 --> 01:29:13,764 BIASES THAT ARE EMBEDDED WITHIN 2398 01:29:13,764 --> 01:29:15,299 THESE TECHNOLOGIES. 2399 01:29:15,299 --> 01:29:16,934 HIS TALK REALLY EXPLORED THE 2400 01:29:16,934 --> 01:29:18,669 INTERSECTION OF A.I., RACIAL 2401 01:29:18,669 --> 01:29:20,738 BIAS, AGING, HIGHLIGHTED THE 2402 01:29:20,738 --> 01:29:22,072 PROFOUND IMPACT THESE BIASES CAN 2403 01:29:22,072 --> 01:29:23,941 HAVE ON OLDER ADULTS FROM 2404 01:29:23,941 --> 01:29:25,142 DIVERSE RACIAL BACKGROUNDS. 2405 01:29:25,142 --> 01:29:26,677 UNFORTUNATELY, WE DIDN'T GET TO 2406 01:29:26,677 --> 01:29:28,045 SEE HIS REAL WORLD EXAMPLES, 2407 01:29:28,045 --> 01:29:32,149 WHICH WOULD HAVE BEEN LOVELY TO 2408 01:29:32,149 --> 01:29:33,250 SEE, IN CASE STUDIES WHERE HE 2409 01:29:33,250 --> 01:29:35,553 WAS GOING TO SHOW US BOTH THE 2410 01:29:35,553 --> 01:29:37,621 POSITIVE AND NEGATIVES THAT CAN 2411 01:29:37,621 --> 01:29:39,924 OCCUR FROM A.I. IN THIS SPACE. 2412 01:29:39,924 --> 01:29:41,992 BUT HIS TALK REALLY TAUGHT US 2413 01:29:41,992 --> 01:29:44,628 THE IMPORTANCE OF DIVERSE DATA 2414 01:29:44,628 --> 01:29:45,229 REPRESENTATION, ACKNOWLEDGING 2415 01:29:45,229 --> 01:29:47,131 THAT OUR CURRENT DATASETS ARE 2416 01:29:47,131 --> 01:29:47,364 BIASED. 2417 01:29:47,364 --> 01:29:51,068 WE HAVE TO ACKNOWLEDGE THAT. 2418 01:29:51,068 --> 01:29:52,303 HE'S DISCUSSED STRATEGIES FOR 2419 01:29:52,303 --> 01:29:53,470 ACHIEVING FAIRNESS, THE ROLE OF 2420 01:29:53,470 --> 01:29:55,139 POLICY AND REGULATION ON 2421 01:29:55,139 --> 01:29:57,741 MITIGATING RACIAL BIAS, AND 2422 01:29:57,741 --> 01:30:00,477 EXPLORING INNOVATIVE A.I. 2423 01:30:00,477 --> 01:30:02,346 SOLUTIONS, ENCOURAGING 2424 01:30:02,346 --> 01:30:04,114 COLLABORATIVE EFFORTS AMONG 2425 01:30:04,114 --> 01:30:05,316 TECHNOLOGISTS AND PROFESSIONALS. 2426 01:30:05,316 --> 01:30:07,151 HE DISCUSSED A LOT ABOUT A.I. 2427 01:30:07,151 --> 01:30:11,221 EVOLUTION AND HOW IT'S AN 2428 01:30:11,221 --> 01:30:12,423 EXISTENTIAL THREAT SOCIALLY, 2429 01:30:12,423 --> 01:30:14,725 ECONOMICALLY BY JOBS, LOSING 2430 01:30:14,725 --> 01:30:16,794 JOBS, GETTING THAT TAKEN AWAY. 2431 01:30:16,794 --> 01:30:18,862 AND THEN THE DATA BIAS AGAIN IN 2432 01:30:18,862 --> 01:30:19,863 THE SYSTEMS THAT WE ALREADY 2433 01:30:19,863 --> 01:30:21,098 HAVE. 2434 01:30:21,098 --> 01:30:23,167 HE DISCUSSED A LOT ABOUT MACHINE 2435 01:30:23,167 --> 01:30:24,702 LEARNING, MACHINE REASONING, 2436 01:30:24,702 --> 01:30:27,538 FAST AND SLOW LEARNING, AND HE 2437 01:30:27,538 --> 01:30:29,673 DISCUSSED A PYRAMID OF A.I. ALL 2438 01:30:29,673 --> 01:30:35,746 THE WAY FROM NIRO TO GENERAL TO 2439 01:30:35,746 --> 01:30:36,513 POSSIBLY MAYBE SENTIENT. 2440 01:30:36,513 --> 01:30:38,282 IT WAS A TRULY FASCINATING TALK. 2441 01:30:38,282 --> 01:30:42,453 WE DIDN'T GET TO KNOW HOW A.I. 2442 01:30:42,453 --> 01:30:46,156 HAS PERPETUATED OR MITIGATED THE 2443 01:30:46,156 --> 01:30:47,257 RACIAL DISPARITY IN THE CASE 2444 01:30:47,257 --> 01:30:47,591 STUDIES. 2445 01:30:47,591 --> 01:30:48,892 I LOOK FORWARD TO READING ABOUT 2446 01:30:48,892 --> 01:30:50,094 WHAT SORT OF THINGS HE'S DONE, 2447 01:30:50,094 --> 01:30:51,495 BECAUSE IT'S TRULY A FASCINATING 2448 01:30:51,495 --> 01:30:52,730 AREA. 2449 01:30:52,730 --> 01:30:57,234 THANK YOU. 2450 01:30:57,234 --> 01:31:00,938 >> OUR NEXT PRESENTER WAS 2451 01:31:00,938 --> 01:31:04,475 DR. CRYSTAL SOCI. 2452 01:31:04,475 --> 01:31:09,079 SHE IS A PROFESSOR AT ARIZONA -- 2453 01:31:09,079 --> 01:31:10,180 ASSISTANT PROFESSOR AT ARIZONA 2454 01:31:10,180 --> 01:31:13,017 STATE UNIVERSITY. 2455 01:31:13,017 --> 01:31:16,620 SHE TALKED TO US ABOUT THE TITLE 2456 01:31:16,620 --> 01:31:18,455 OF HER PRESENTATION WAS 2457 01:31:18,455 --> 01:31:20,758 INDIGENOUS GENOMIC DATA 2458 01:31:20,758 --> 01:31:22,192 SOVEREIGNTY THROUGH TRIBAL DATA 2459 01:31:22,192 --> 01:31:24,061 REPOSITORY FOR HEALTH EQUITY. 2460 01:31:24,061 --> 01:31:26,463 AND DR. SOCI TALKED ABOUT THE 2461 01:31:26,463 --> 01:31:29,299 IMPORTANCE OF AVOIDING 2462 01:31:29,299 --> 01:31:31,535 ENGAGEMENT WATCHING, WHICH IS 2463 01:31:31,535 --> 01:31:33,937 DEFINED AS WHEN RESEARCHERS 2464 01:31:33,937 --> 01:31:41,045 RECOGNIZE THE ETHICAL AND 2465 01:31:41,045 --> 01:31:41,912 EPISTEMOLOGICAL IMPERATIVE TO 2466 01:31:41,912 --> 01:31:45,449 ENGAGE WITH STA STAKEHOLDERS, BT 2467 01:31:45,449 --> 01:31:47,418 PURSUE SUCH ENGAGEMENT ONLY TO 2468 01:31:47,418 --> 01:31:48,819 SATISFY REPUTATIONAL AIMS TO 2469 01:31:48,819 --> 01:31:51,121 MAINTAIN THE STATUS QUO. 2470 01:31:51,121 --> 01:31:52,890 DR. SOCI ALSO INDICATED THAT 2471 01:31:52,890 --> 01:31:54,425 COMMUNITY ENGAGEMENT CAN BE 2472 01:31:54,425 --> 01:31:56,493 CHALLENGING, DUE TO LACK OF 2473 01:31:56,493 --> 01:31:58,595 RESEARCHER TRAINING IN 2474 01:31:58,595 --> 01:32:00,030 ENGAGEMENT METHODS, AND 2475 01:32:00,030 --> 01:32:02,533 QUALITATIVE TRAINING, THAT 2476 01:32:02,533 --> 01:32:05,803 THERE'S A LACK OF LOCAL RESEARCH 2477 01:32:05,803 --> 01:32:08,739 INFRASTRUCTURE, THAT THERE'S -- 2478 01:32:08,739 --> 01:32:10,541 IT IS DIFFICULT TO IDENTIFY 2479 01:32:10,541 --> 01:32:12,843 LOCAL KEY EXPERTS, AND THERE'S 2480 01:32:12,843 --> 01:32:15,245 LACK OF CONSENSUS WHEN THERE ARE 2481 01:32:15,245 --> 01:32:17,548 MANY COMMUNITIES INVOLVED. 2482 01:32:17,548 --> 01:32:21,251 AND THAT THERE'S ALSO 2483 01:32:21,251 --> 01:32:22,486 CONFLICTING INSTITUTIONAL VERSUS 2484 01:32:22,486 --> 01:32:25,422 COMMUNITY POLICIES. 2485 01:32:25,422 --> 01:32:28,292 SHE ALSO INDICATED THAT 2486 01:32:28,292 --> 01:32:30,594 SITUATING ENGAGEMENT WITHIN 2487 01:32:30,594 --> 01:32:33,530 CURRENT PRACTICES CAN BE 2488 01:32:33,530 --> 01:32:35,299 CHALLENGING, BECAUSE GRANT 2489 01:32:35,299 --> 01:32:37,267 FUNDING DOESN'T ADEQUATELY FUND 2490 01:32:37,267 --> 01:32:38,435 ENGAGEMENT. 2491 01:32:38,435 --> 01:32:42,072 AND THAT RESEARCHERS ARE NOT 2492 01:32:42,072 --> 01:32:43,073 CROSS-TRAINED IN COMMUNITY 2493 01:32:43,073 --> 01:32:43,841 ENGAGEMENT. 2494 01:32:43,841 --> 01:32:47,010 SHE ALSO HIGHLIGHTED THAT WE DO 2495 01:32:47,010 --> 01:32:48,645 NOT TALK ABOUT COMMUNITY 2496 01:32:48,645 --> 01:32:53,016 ENGAGEMENT THROUGHOUT THE 2497 01:32:53,016 --> 01:32:53,851 LIFECYCLE OF THE RESEARCH 2498 01:32:53,851 --> 01:32:54,885 PROCESS. 2499 01:32:54,885 --> 01:32:58,822 IT IS MUCH EASIER TO DEFAULT TO 2500 01:32:58,822 --> 01:33:01,024 MINIMUM STANDARDS THAN ACTUAL 2501 01:33:01,024 --> 01:33:02,926 ENGAGEMENT. 2502 01:33:02,926 --> 01:33:04,428 BUT IS THIS TRULY ETHICAL, SHE 2503 01:33:04,428 --> 01:33:06,930 ASKED? 2504 01:33:06,930 --> 01:33:08,832 DR. SOCI ALSO REMINDED US THAT A 2505 01:33:08,832 --> 01:33:10,801 KEY ELEMENT IN RESEARCH IS 2506 01:33:10,801 --> 01:33:12,603 MAKING SURE THAT OUR CHILDREN'S 2507 01:33:12,603 --> 01:33:14,638 CHILDREN WILL BE ABLE TO BENEFIT 2508 01:33:14,638 --> 01:33:16,607 FROM THE RESEARCH THAT IS 2509 01:33:16,607 --> 01:33:17,174 CONDUCTED. 2510 01:33:17,174 --> 01:33:18,809 SHE ALSO TALKED ABOUT THE LACK 2511 01:33:18,809 --> 01:33:22,312 OF INDIGENOUS ENGAGEMENT IN 2512 01:33:22,312 --> 01:33:22,746 GENOMICS. 2513 01:33:22,746 --> 01:33:24,948 SHE HIGHLIGHTED THAT RECENT AND 2514 01:33:24,948 --> 01:33:27,351 PAST UNETHICAL RESEARCH 2515 01:33:27,351 --> 01:33:29,987 INVOLVING DATA COLLECTION FROM 2516 01:33:29,987 --> 01:33:31,522 INDIGENOUS COMMUNITIES HAS 2517 01:33:31,522 --> 01:33:35,359 STRAINED TRUST RELATIONS, 2518 01:33:35,359 --> 01:33:36,660 RESULTING IN TRIBAL NATION 2519 01:33:36,660 --> 01:33:41,799 POLICIES THAT RESTRICT GENOMICS 2520 01:33:41,799 --> 01:33:43,033 RESEARCH IN OPEN DATA SHARING. 2521 01:33:43,033 --> 01:33:44,234 SHE ALSO TALKED ABOUT 2522 01:33:44,234 --> 01:33:46,436 RE-THINKING INFORMED CONSENT 2523 01:33:46,436 --> 01:33:48,639 LANGUAGE, INDICATING THAT 2524 01:33:48,639 --> 01:33:49,706 ETHICALLY, THE STANDARD FOR 2525 01:33:49,706 --> 01:33:54,311 INDIVIDUAL INFORMED CONSENT IS 2526 01:33:54,311 --> 01:33:55,612 INADEQUATE FOR INDIGENOUS 2527 01:33:55,612 --> 01:33:56,613 COMMUNITIES, ESPECIALLY FOR 2528 01:33:56,613 --> 01:34:03,520 GENOMICS. 2529 01:34:03,520 --> 01:34:03,854 DR. SCHNEIDER? 2530 01:34:03,854 --> 01:34:04,922 >> THANK YOU. 2531 01:34:04,922 --> 01:34:06,857 OKAY, SO OUR LAST SPEAKER, WE 2532 01:34:06,857 --> 01:34:08,892 TOOK A LITTLE BIT OF A CHANGE 2533 01:34:08,892 --> 01:34:16,433 AND WE ASKED JASON FLATT TO GIVE 2534 01:34:16,433 --> 01:34:17,100 A TALK. 2535 01:34:17,100 --> 01:34:19,636 HE SPOKES ON METHODS FOR 2536 01:34:19,636 --> 01:34:21,371 RECRUITMENT AND ENGAGEMENT OF 2537 01:34:21,371 --> 01:34:22,706 SEXUAL AND GENDER MINORITY OLDER 2538 01:34:22,706 --> 01:34:24,541 ADULTS IN AGING RESEARCH. 2539 01:34:24,541 --> 01:34:25,809 DR. FLATT IS AN ASSOCIATE 2540 01:34:25,809 --> 01:34:27,311 PROFESSOR AT THE UNIVERSITY OF 2541 01:34:27,311 --> 01:34:28,178 NEVADA LAS VEGAS. 2542 01:34:28,178 --> 01:34:30,380 HE'S TRAINED IN GERONTOLOGY AND 2543 01:34:30,380 --> 01:34:31,148 EPIDEMIOLOGY. 2544 01:34:31,148 --> 01:34:35,185 HE BEGAN HIS RESEARCH -- 2545 01:34:35,185 --> 01:34:36,720 CONDUCTING RESEARCH WITH THE 2546 01:34:36,720 --> 01:34:38,055 DIVERSE, SEXUAL AND GENDER 2547 01:34:38,055 --> 01:34:40,791 MINORITIES, WHICH I LEARNED IS 2548 01:34:40,791 --> 01:34:41,992 LESBIAN, GAY, BISEXUAL, 2549 01:34:41,992 --> 01:34:44,294 TRANSGENDER, QUEER, INTERSEX, 2550 01:34:44,294 --> 01:34:46,163 ASEXUAL AND ANOTHER IDENTITY 2551 01:34:46,163 --> 01:34:47,497 PERSONS LIVING WITH ALZHEIMER'S 2552 01:34:47,497 --> 01:34:49,700 DISEASE AND RELATED DEMENTIAS 2553 01:34:49,700 --> 01:34:50,901 AND THEIR CAREGIVERS. 2554 01:34:50,901 --> 01:34:52,302 JUST AN ASIDE, HE SAID AT THE 2555 01:34:52,302 --> 01:34:53,403 VERY BEGINNING THAT THAT'S 2556 01:34:53,403 --> 01:34:54,705 NOT -- THAT'S A SCIENTIFIC TERM, 2557 01:34:54,705 --> 01:34:56,039 NOT THE TERM THAT THEY USE IN 2558 01:34:56,039 --> 01:34:57,374 THE COMMUNITY, AND WE SHOULD 2559 01:34:57,374 --> 01:34:58,876 KNOW THE REAL TERMS THAT THEY 2560 01:34:58,876 --> 01:35:00,410 USE IN THE COMMUNITY WHEN WE DO 2561 01:35:00,410 --> 01:35:02,946 GO OUT IN THE COMMUNITY. 2562 01:35:02,946 --> 01:35:05,883 HIS RESEARCH INVOLVES SGM OLDER 2563 01:35:05,883 --> 01:35:08,652 ADULTS AND CAREGIVERS TO HELP 2564 01:35:08,652 --> 01:35:11,054 UNDERSTAND ADRD RISK AND 2565 01:35:11,054 --> 01:35:11,822 DISPARITIES, LONG-TERM CARE AND 2566 01:35:11,822 --> 01:35:13,123 RELATED HEALTH NEEDS, WORKFORCE 2567 01:35:13,123 --> 01:35:14,258 CHALLENGES AND POTENTIAL 2568 01:35:14,258 --> 01:35:15,926 SOLUTIONS. 2569 01:35:15,926 --> 01:35:18,228 HE IS CURRENTLY WORKING ON RISE, 2570 01:35:18,228 --> 01:35:22,699 WHICH IS RESEARCH INCLUSION 2571 01:35:22,699 --> 01:35:23,934 SUPPORT EQUITY REGISTRY. 2572 01:35:23,934 --> 01:35:25,669 IT'S THE FIRST REGISTRY TO 2573 01:35:25,669 --> 01:35:27,638 RECRUIT, ENGAGE AND RETAIN 2574 01:35:27,638 --> 01:35:29,373 SEXUAL GENDER MINORITY OLDER 2575 01:35:29,373 --> 01:35:32,910 ADULTS WITH ADRD AND THE 2576 01:35:32,910 --> 01:35:34,544 CAREGIVERS OF SEXUAL GENDER 2577 01:35:34,544 --> 01:35:36,280 MINORITY ADRD. 2578 01:35:36,280 --> 01:35:37,981 SO REALLY IMPORTANT FIRST 2579 01:35:37,981 --> 01:35:40,450 ATTEMPT AT GETTING A REGISTRY IN 2580 01:35:40,450 --> 01:35:43,654 PLACE TO START HELPING AND 2581 01:35:43,654 --> 01:35:47,491 LEARNING ABOUT THIS COMMUNITY. 2582 01:35:47,491 --> 01:35:49,059 HE ALSO SPOKE ABOUT RAINBOWS OF 2583 01:35:49,059 --> 01:35:50,894 CARE, WHICH IS ANOTHER PROJECT 2584 01:35:50,894 --> 01:35:54,731 THAT HE IS INVOLVED WITH, WHICH 2585 01:35:54,731 --> 01:35:55,599 MEASURES AND CHARACTERIZES THE 2586 01:35:55,599 --> 01:35:58,268 ROLE AND EXPERIENCES OF SEXUAL 2587 01:35:58,268 --> 01:36:00,003 GENDER MINORITIES LIVING WITH 2588 01:36:00,003 --> 01:36:02,873 ADRD, AND EXTENDS 2589 01:36:02,873 --> 01:36:03,840 CONCEPTUALIZATION OF SEXUAL 2590 01:36:03,840 --> 01:36:06,810 GENERGENDER MINORITIES IN CAREGG 2591 01:36:06,810 --> 01:36:09,313 RELATIONSHIPS AND ROLES. 2592 01:36:09,313 --> 01:36:13,183 HE DESCRIBED NEW DATA ON RISK 2593 01:36:13,183 --> 01:36:16,019 FACTORS. 2594 01:36:16,019 --> 01:36:18,655 HIS MAJOR -- LET'S SEE IF I 2595 01:36:18,655 --> 01:36:19,957 WROTE THIS HERE. 2596 01:36:19,957 --> 01:36:21,725 HIS MAJOR CONTRIBUTION TO 2597 01:36:21,725 --> 01:36:23,193 SCIENCE INVOLVES SOCIAL AND 2598 01:36:23,193 --> 01:36:24,761 BEHAVIORAL HEALTH RESEARCH AMONG 2599 01:36:24,761 --> 01:36:28,966 SEXUAL GENDER MY IN OT MINORITIN 2600 01:36:28,966 --> 01:36:30,734 ADRD, HE'S ALSO INVOLVED IN 2601 01:36:30,734 --> 01:36:33,904 CAREGIVING, HE'S ALSO INVOLVED 2602 01:36:33,904 --> 01:36:35,305 IN RECRUITMENT AS WELL AS HEALTH 2603 01:36:35,305 --> 01:36:35,973 SERVICES. 2604 01:36:35,973 --> 01:36:37,407 HE DESCRIBED A LOT OF NEW DATA 2605 01:36:37,407 --> 01:36:39,176 OVER ALL THESE DIFFERENT AREAS 2606 01:36:39,176 --> 01:36:40,610 ON RISK AND CAREGIVING. 2607 01:36:40,610 --> 01:36:42,446 HE SPOKE ABOUT HAVING HIGHER 2608 01:36:42,446 --> 01:36:45,949 SUBJECTIVE COGNITIVE COMPLAINTS 2609 01:36:45,949 --> 01:36:47,951 IN PEOPLE WITH SGM, AND 2610 01:36:47,951 --> 01:36:49,019 DIFFERENCES IN MEN VERSUS WOMEN. 2611 01:36:49,019 --> 01:36:52,756 SO HE IS FINDING DIFFERENCES IN 2612 01:36:52,756 --> 01:36:53,290 RISK FACTORS. 2613 01:36:53,290 --> 01:36:56,259 HE ALSO SPOKE ABOUT CAREGIVING, 2614 01:36:56,259 --> 01:36:58,028 WHICH IS REALLY IMPORTANT IN 2615 01:36:58,028 --> 01:37:01,198 THAT COMMUNITY WHERE THERE MAY 2616 01:37:01,198 --> 01:37:05,469 NOT BE KIN AND SPOKE OF THE 2617 01:37:05,469 --> 01:37:07,971 GROUPS OF PEOPLE AND FRIENDS 2618 01:37:07,971 --> 01:37:10,273 THAT PEOPLE MAY USE WHO HAVE 2619 01:37:10,273 --> 01:37:14,311 ADRD IN THAT COMMUNITY TO HAVE 2620 01:37:14,311 --> 01:37:16,246 DIFFERENT NEEDS FULFILLED, AND 2621 01:37:16,246 --> 01:37:17,514 THAT WE NEED TO START THINKING 2622 01:37:17,514 --> 01:37:18,648 ABOUT CAREGIVING IN A DIFFERENT 2623 01:37:18,648 --> 01:37:20,183 WAY, PERHAPS, OR AN EXTENDED WAY 2624 01:37:20,183 --> 01:37:21,284 WITHIN THAT COMMUNITY. 2625 01:37:21,284 --> 01:37:25,188 THERE WAS A LOT OF QUESTIONS FOR 2626 01:37:25,188 --> 01:37:26,857 DR. FLATT, AND I THINK WE ALL 2627 01:37:26,857 --> 01:37:28,392 LEARNED A LOT ABOUT HOW MUCH 2628 01:37:28,392 --> 01:37:31,128 RESEARCH IS NEEDED STILL IN THAT 2629 01:37:31,128 --> 01:37:34,865 COMMUNITY. 2630 01:37:34,865 --> 01:37:35,766 >> ALL RIGHT, GREAT. 2631 01:37:35,766 --> 01:37:38,268 THANK YOU VERY MUCH, DRS. CRUZ 2632 01:37:38,268 --> 01:37:39,269 AND SCHNEIDER FOR THE SYNOPSIS 2633 01:37:39,269 --> 01:37:41,505 OF OUR TASK FORCE. 2634 01:37:41,505 --> 01:37:42,806 PATRICIA, ANYTHING MORE TO ADD? 2635 01:37:42,806 --> 01:37:43,673 OKAY. 2636 01:37:43,673 --> 01:37:45,442 THANK YOU VERY MUCH. 2637 01:37:45,442 --> 01:37:47,944 ANY FINAL COMMENTS OR QUESTIONS 2638 01:37:47,944 --> 01:37:49,713 REGARDING THE PRESENTATIONS 2639 01:37:49,713 --> 01:37:56,053 DURING THE TASK FORCE? 2640 01:37:56,053 --> 01:37:56,620 ALL RIGHT. 2641 01:37:56,620 --> 01:37:57,587 THEN WE'LL MOVE ON. 2642 01:37:57,587 --> 01:38:00,891 I'LL TURN THIS NOW OVER TO THE 2643 01:38:00,891 --> 01:38:02,225 CHAIR OF OUR WORKING GROUP ON 2644 01:38:02,225 --> 01:38:04,194 PROGRAM, DR. SUSAN GREENSPAN. 2645 01:38:04,194 --> 01:38:05,629 SUSAN. 2646 01:38:05,629 --> 01:38:08,498 >> THANK YOU, KEN. 2647 01:38:08,498 --> 01:38:11,701 YESTERDAY WE DISCUSSED 21 2648 01:38:11,701 --> 01:38:11,968 CONCEPTS. 2649 01:38:11,968 --> 01:38:14,071 WE HAD SOME LIVELY AND 2650 01:38:14,071 --> 01:38:15,038 INTERESTING DISCUSSION. 2651 01:38:15,038 --> 01:38:18,508 AND WE'LL PRESENT THOSE CONCEPTS 2652 01:38:18,508 --> 01:38:20,544 NOW. 2653 01:38:20,544 --> 01:38:24,147 THE FIRST CONCEPT WILL BE RNA 2654 01:38:24,147 --> 01:38:25,582 METABOLISM IN AGING AND AGING 2655 01:38:25,582 --> 01:38:26,817 RELATED DISEASES, AND WE WILL 2656 01:38:26,817 --> 01:38:28,985 JUST HAVE THE PRIMARY REVIEWER 2657 01:38:28,985 --> 01:38:33,490 GIVE A BRIEF SYNOPSIS OF THE 2658 01:38:33,490 --> 01:38:35,125 CONCEPT AND THE DISCUSSION. 2659 01:38:35,125 --> 01:38:38,962 THE PRIMARY REVIEWER WAS 2660 01:38:38,962 --> 01:38:40,630 DR. HUANG, THE SECOND WAS 2661 01:38:40,630 --> 01:38:41,898 DR. BAKER, BUT JUST DR. HUANG, 2662 01:38:41,898 --> 01:38:42,899 IF YOU COULD PRESENT YOUR 2663 01:38:42,899 --> 01:38:44,601 SUMMARY. 2664 01:38:44,601 --> 01:38:45,735 >> YES. 2665 01:38:45,735 --> 01:38:48,672 THIS IS A COLLABORATIVE CONCEPT 2666 01:38:48,672 --> 01:38:56,646 PROPOSAL OF RNA METABOLISM, THE 2667 01:38:56,646 --> 01:38:58,181 CONCEPT FOCUSING ON GENERAL 2668 01:38:58,181 --> 01:38:59,950 AGING AND AGING-RELATED DISEASE. 2669 01:38:59,950 --> 01:39:02,119 THIS CONCEPT IS ALSO 2670 01:39:02,119 --> 01:39:04,121 COMPLEMENTARY AND SYNERGISTIC 2671 01:39:04,121 --> 01:39:07,858 WITH THE PREVIOUSLY ANNOUNCED 2672 01:39:07,858 --> 01:39:09,159 TWO RFAs. 2673 01:39:09,159 --> 01:39:15,432 IT CLEARLY ADDRESSES THE NIA'S 2674 01:39:15,432 --> 01:39:16,733 STRATEGIC GOAL OF IMPROVING OUR 2675 01:39:16,733 --> 01:39:18,068 UNDERSTANDING OF HEALTHY AGING 2676 01:39:18,068 --> 01:39:19,603 AND DISEASE AND DISABILITY AMONG 2677 01:39:19,603 --> 01:39:21,238 OLDER ADULTS. 2678 01:39:21,238 --> 01:39:24,207 THE PRIMARY GOAL OF THIS CONCEPT 2679 01:39:24,207 --> 01:39:26,109 IS TO SOLICIT STUDIES THAT WOULD 2680 01:39:26,109 --> 01:39:29,146 IDENTIFY AND CHARACTERIZE THE 2681 01:39:29,146 --> 01:39:30,914 CHANGE OF RNA EDITING, 2682 01:39:30,914 --> 01:39:33,316 ALTERNATIVE SPLICING AND RNA 2683 01:39:33,316 --> 01:39:34,117 MODIFICATION THAT ARE ASSOCIATED 2684 01:39:34,117 --> 01:39:37,053 WITH THE AGING PROCESS AND CAUSE 2685 01:39:37,053 --> 01:39:41,658 THE DISEASE, EITHER CELLULARLY 2686 01:39:41,658 --> 01:39:43,426 AND MECHANISTICALLY THERE. 2687 01:39:43,426 --> 01:39:45,729 ALL THESE THREE RNA-RELATED AREA 2688 01:39:45,729 --> 01:39:48,031 HAD TO BE HINDERED BY THE 2689 01:39:48,031 --> 01:39:49,499 OBSTACLES ASSOCIATED WITH THE 2690 01:39:49,499 --> 01:39:53,870 COSTS AND TECHNOLOGY -- IN THE 2691 01:39:53,870 --> 01:39:55,739 PAST LIMITING -- A LOT OF 2692 01:39:55,739 --> 01:39:57,674 LIMITING FACTORS THERE. 2693 01:39:57,674 --> 01:40:00,243 HOWEVER RECENT TECHNIQUE 2694 01:40:00,243 --> 01:40:01,678 DEVELOPMENT HAVE REVOLUTIONIZED 2695 01:40:01,678 --> 01:40:03,847 THE FIELD AND PRESENTS A NEW 2696 01:40:03,847 --> 01:40:05,182 LANDSCAPE, THUS IT IS THE RIGHT 2697 01:40:05,182 --> 01:40:09,019 TIME NOW TO STIMULATE THE STUDY 2698 01:40:09,019 --> 01:40:14,291 OF RNA METABOLISM IN THE 2699 01:40:14,291 --> 01:40:16,359 UNDERLYING CELLULAR AND TISSUE 2700 01:40:16,359 --> 01:40:18,695 FUNCTION CONTRIBUTED TO AGING OR 2701 01:40:18,695 --> 01:40:19,563 AGING RELATED DISEASE. 2702 01:40:19,563 --> 01:40:21,965 THIS NOF CONCEPT PROPOSAL IS RFA 2703 01:40:21,965 --> 01:40:24,301 USING R01 GRANT MECHANISMS, AND 2704 01:40:24,301 --> 01:40:26,803 DURING THE DISCUSSION, THE 2705 01:40:26,803 --> 01:40:28,305 COUNCIL ALL AGREED THAT THIS IS 2706 01:40:28,305 --> 01:40:32,776 A WELL DESIGNED TIMELY AND 2707 01:40:32,776 --> 01:40:37,047 IMPORTANT CONCEPT PROPOSAL AND 2708 01:40:37,047 --> 01:40:37,347 SUPPORT IT. 2709 01:40:37,347 --> 01:40:37,714 THANK YOU. 2710 01:40:37,714 --> 01:40:39,115 >> THANK YOU. 2711 01:40:39,115 --> 01:40:42,986 THE NEXT CONCEPT, BATS AND 2712 01:40:42,986 --> 01:40:47,591 HEALTHY AGING, DR. HUANG WAS THE 2713 01:40:47,591 --> 01:40:51,428 PRIMARY REVIEWER, DR. BAKER THE 2714 01:40:51,428 --> 01:40:52,529 SECONDARY REVIEWER, AND 2715 01:40:52,529 --> 01:40:56,800 DR. HUANG, AGAIN IF YOU CAN 2716 01:40:56,800 --> 01:40:58,134 PRESENT THE PROPOSAL AND YOUR 2717 01:40:58,134 --> 01:40:58,401 COMMENTS. 2718 01:40:58,401 --> 01:41:01,104 >> THIS IS ALSO A COLLABORATION 2719 01:41:01,104 --> 01:41:03,607 CONCEPT PROS AL SPONSORED BY ALL 2720 01:41:03,607 --> 01:41:04,841 FOUR DIVISIONS AT NIA. 2721 01:41:04,841 --> 01:41:07,444 AS YOU ALL KNOW AGING IS A 2722 01:41:07,444 --> 01:41:09,546 PRIMARY RISK FACTOR FOR SEVERAL 2723 01:41:09,546 --> 01:41:11,748 MAJOR HUMAN DISEASE CONDITIONS. 2724 01:41:11,748 --> 01:41:13,450 THE INCREASED AVERAGE LIFESPAN 2725 01:41:13,450 --> 01:41:14,684 OVER THE LAST DECADE IS ONE OF 2726 01:41:14,684 --> 01:41:16,486 THE MOST REMARKABLE HUMAN 2727 01:41:16,486 --> 01:41:18,455 ACCOMPLISHMENT, ALTHOUGH THIS 2728 01:41:18,455 --> 01:41:22,926 SUCCESS HAS ALSO LED TO -- 2729 01:41:22,926 --> 01:41:25,228 NAMELY THE INCREASED NUMBER OF 2730 01:41:25,228 --> 01:41:26,129 CHRONICALLY ILL PATIENTS 2731 01:41:26,129 --> 01:41:27,664 SUFFERING FROM AGE-RELATED 2732 01:41:27,664 --> 01:41:30,634 DISEASE AND THE RESULTING TOLL 2733 01:41:30,634 --> 01:41:32,602 ON INDIVIDUALS AND SOCIETY. 2734 01:41:32,602 --> 01:41:34,938 SO IT TURNS OUT BATS ARE 2735 01:41:34,938 --> 01:41:37,140 EMERGING AS AN IMPORTANT ANIMAL 2736 01:41:37,140 --> 01:41:39,175 MODEL FOR AGING STUDIES. 2737 01:41:39,175 --> 01:41:41,945 IN CONTRAST TO SOME COMMON 2738 01:41:41,945 --> 01:41:43,947 LABORATORY ANIMAL MODELS SUCH AS 2739 01:41:43,947 --> 01:41:48,418 MICE AND RATS BEST MEET -- 2740 01:41:48,418 --> 01:41:50,854 CRITERIA FOR AGING STUDIES. 2741 01:41:50,854 --> 01:41:52,489 THEY LIVE LONG IN THE WILD AND 2742 01:41:52,489 --> 01:41:55,125 ALSO IN CAPTIVITY FOR 20, 30 OR 2743 01:41:55,125 --> 01:41:58,895 EVEN MORE THAN 40 YEARS. 2744 01:41:58,895 --> 01:42:00,530 ACTUALLY OF THE 19 SPECIES THAT 2745 01:42:00,530 --> 01:42:02,732 LIVE LONGER THAN HUMANS, 18 ARE 2746 01:42:02,732 --> 01:42:03,066 BATS. 2747 01:42:03,066 --> 01:42:06,469 SO WITH ALL THIS CURRENT YEARS 2748 01:42:06,469 --> 01:42:08,672 INCREASING SHORTAGE OF AGING 2749 01:42:08,672 --> 01:42:10,073 NON-HUMAN PRIMATES WITH 2750 01:42:10,073 --> 01:42:11,608 RESEARCH, THERE IS A NEED FOR 2751 01:42:11,608 --> 01:42:13,410 OTHER MODELS, IMPORTANTLY, 2752 01:42:13,410 --> 01:42:16,046 UNLIKE NON-HUMAN PRIMATES, 2753 01:42:16,046 --> 01:42:20,850 MAINTAINING CAPTIVE BAT COLONIES 2754 01:42:20,850 --> 01:42:22,519 ARE RELATIVELY EASIER AND MUCH 2755 01:42:22,519 --> 01:42:22,886 MORE AFFORDABLE. 2756 01:42:22,886 --> 01:42:25,288 SO BASED ON ALL THIS, NIA 2757 01:42:25,288 --> 01:42:27,157 ORGANIZED A WORKSHOP EARLIER 2758 01:42:27,157 --> 01:42:29,225 THIS YEAR AND BRINGING IN THE 2759 01:42:29,225 --> 01:42:30,860 EXPERTISE TO TALK ABOUT THIS AND 2760 01:42:30,860 --> 01:42:33,530 THE CONSENSUS WAS THAT WE SHOULD 2761 01:42:33,530 --> 01:42:35,565 LEVERAGE ON THIS ADVANTAGE OF 2762 01:42:35,565 --> 01:42:39,235 THE BATS RESEARCH OFFER NEW 2763 01:42:39,235 --> 01:42:42,839 COMPLEMENTARY SYSTEM FOR AGING 2764 01:42:42,839 --> 01:42:43,707 RESEARCH. 2765 01:42:43,707 --> 01:42:52,716 THIS NOF ALSO USES RFA AND USING 2766 01:42:52,716 --> 01:42:57,320 BIOPHYSIC -- MECHANISM GIVES THE 2767 01:42:57,320 --> 01:42:59,055 OPPORTUNITY FOR -- TO START SOME 2768 01:42:59,055 --> 01:43:01,391 IDEA AND THEN MORE AHEAD IF IT 2769 01:43:01,391 --> 01:43:03,493 WAS SUCCESS TO THE R33 STAGE. 2770 01:43:03,493 --> 01:43:05,362 AND DURING THIS DISCUSSION, THE 2771 01:43:05,362 --> 01:43:07,364 COUNCIL AGREED THAT THIS IS ALSO 2772 01:43:07,364 --> 01:43:09,666 A WELL DESIGNED TIMELY AND 2773 01:43:09,666 --> 01:43:14,671 IMPORTANT CONCEPT PROPOSAL. 2774 01:43:14,671 --> 01:43:16,373 A VERY NOVEL SYSTEM FOR AGING 2775 01:43:16,373 --> 01:43:18,775 RESEARCH AND ALSO 2776 01:43:18,775 --> 01:43:19,342 ENTHUSIASTICALLY SUPPORTED. 2777 01:43:19,342 --> 01:43:19,743 THANK YOU. 2778 01:43:19,743 --> 01:43:20,944 >> THANK YOU, DR. HUANG. 2779 01:43:20,944 --> 01:43:23,079 ONCE AGAIN, YOU'RE UP AGAIN. 2780 01:43:23,079 --> 01:43:26,683 OUR THIRD CONCEPT, AGING M 2781 01:43:26,683 --> 01:43:28,685 MAMMALIAN TISSUES IN VITRO. 2782 01:43:28,685 --> 01:43:30,220 DR. HUANG IS THE PRIMARY 2783 01:43:30,220 --> 01:43:32,956 REVIEWER, DR. BAKER WAS THE 2784 01:43:32,956 --> 01:43:34,190 SECONDARY REVIEWER. 2785 01:43:34,190 --> 01:43:34,591 DR. HUANG, PLEASE. 2786 01:43:34,591 --> 01:43:36,493 >> THIS IS ANOTHER COLLABORATIVE 2787 01:43:36,493 --> 01:43:37,794 CONCEPT PROPOSAL, AGAIN 2788 01:43:37,794 --> 01:43:40,463 SPONSORED BY THREE OF THESE FOUR 2789 01:43:40,463 --> 01:43:44,167 NIA DIVISIONS. 2790 01:43:44,167 --> 01:43:45,368 SO THE INSIGHTS IN RECENT YEARS 2791 01:43:45,368 --> 01:43:47,137 FROM ANIMAL RESEARCH HIGHLIGHT 2792 01:43:47,137 --> 01:43:52,409 THE NEED FOR HUMAN CENTERED 2793 01:43:52,409 --> 01:43:53,209 MODELS. 2794 01:43:53,209 --> 01:43:57,680 TOWARD THIS DIRECTION, ADVANCES 2795 01:43:57,680 --> 01:44:01,885 SINCE IN YEAR 2007, THE 2796 01:44:01,885 --> 01:44:03,386 ESTABLISHMENT OF THE SOMATIC 2797 01:44:03,386 --> 01:44:11,294 CELERY PROCELL STEM CELL TECHNOE 2798 01:44:11,294 --> 01:44:14,831 THE BROAD AVAILABILITY OF THE 2799 01:44:14,831 --> 01:44:16,166 COMPLEX DI DIMENSIONAL CULTURE 2800 01:44:16,166 --> 01:44:20,069 SYSTEM THAT MORE CLOSELY 2801 01:44:20,069 --> 01:44:21,404 RECONSTRUCTS THE -- ORGAN MORE 2802 01:44:21,404 --> 01:44:24,507 CLOSE TO HUMAN, AND FURTHERMORE 2803 01:44:24,507 --> 01:44:27,076 THE INTERDUS IN THE YEAR 2022 OF 2804 01:44:27,076 --> 01:44:29,879 THE U.S. FDA MODERNIZATION ACT 2805 01:44:29,879 --> 01:44:31,147 2.0 ALLOWS FOR ALTERNATIVE TO 2806 01:44:31,147 --> 01:44:32,515 ANIMAL TESTING FOR PURPOSE OF 2807 01:44:32,515 --> 01:44:34,517 DRUG TESTING USE IN THIS KIND OF 2808 01:44:34,517 --> 01:44:35,285 SYSTEM. 2809 01:44:35,285 --> 01:44:38,388 HOWEVER, THE MAIN CHALLENGE IS 2810 01:44:38,388 --> 01:44:43,426 HOW TO FAITHFULLY AND 2811 01:44:43,426 --> 01:44:44,394 REPRODUCIBLY ENCAPSULATE THE 2812 01:44:44,394 --> 01:44:48,598 AGING PROCESS OR PHENOTYPES IN 2813 01:44:48,598 --> 01:44:49,799 BETWEEN -- JUST A FEW MONTHS 2814 01:44:49,799 --> 01:44:52,101 AGO, THIS YEAR, A HYBRID 2815 01:44:52,101 --> 01:44:54,671 WORKSHOP ON THE 3D IN VITRO 2816 01:44:54,671 --> 01:44:56,005 TISSUE SYSTEM FOR RESEARCH ON 2817 01:44:56,005 --> 01:44:59,042 AGING BRINGS IN EXPERTISE AND 2818 01:44:59,042 --> 01:45:01,744 ALLOWED DISCUSSION, AGAIN, THE 2819 01:45:01,744 --> 01:45:02,812 CONSENSUS SHOULD LEVERAGE ON 2820 01:45:02,812 --> 01:45:06,115 THIS HUMAN CELL CULTURE SYSTEM, 2821 01:45:06,115 --> 01:45:07,784 AND FOR THE SUPPORT THIS AGING 2822 01:45:07,784 --> 01:45:09,786 RESEARCH AND ALSO FOR THE FUTURE 2823 01:45:09,786 --> 01:45:13,490 DRUG SCREENING OR TASK, THIS 2824 01:45:13,490 --> 01:45:17,227 PROPOSED NOF IS ALSO RFA WITH 2825 01:45:17,227 --> 01:45:19,095 R21 FUNDING MECHANISM SUPPORTING 2826 01:45:19,095 --> 01:45:22,932 EXPLORATORY PROJECTS, AND ALSO 2827 01:45:22,932 --> 01:45:24,234 DURING THE DISCUSSION, THE 2828 01:45:24,234 --> 01:45:26,336 COUNCIL RECOGNIZED THAT THIS IS 2829 01:45:26,336 --> 01:45:30,440 A TIMELY IMPORTANT EXPLORATORY 2830 01:45:30,440 --> 01:45:36,613 PROGRAM, AND AL ALSO 2831 01:45:36,613 --> 01:45:37,347 ENTHUSIASTICALLY SUPPORTED. 2832 01:45:37,347 --> 01:45:37,814 >> THANK YOU. 2833 01:45:37,814 --> 01:45:39,682 THE NEXT CONCEPT, THE NATIONAL 2834 01:45:39,682 --> 01:45:41,384 LONGITUDAL STUDY OF ADOLESCENT 2835 01:45:41,384 --> 01:45:43,786 TO ADULT HEALTH, ADD HEALTH, 2836 01:45:43,786 --> 01:45:45,321 WAVE VII. 2837 01:45:45,321 --> 01:45:49,859 DR. CASE WAS THE PRIMARY 2838 01:45:49,859 --> 01:45:53,096 REVIEWER, DR. ASTHANA WAS THE 2839 01:45:53,096 --> 01:45:57,166 SECOND REVIEWER AND DR. HUMMER. 2840 01:45:57,166 --> 01:45:59,168 >> THERE WAS ENTHUSIASM FOR THIS 2841 01:45:59,168 --> 01:46:02,805 RFA NOFO FOR A U01 RENEWAL TO 2842 01:46:02,805 --> 01:46:05,341 FUND WAVE VII OF ADD HEALTH. 2843 01:46:05,341 --> 01:46:07,243 WHICH WAS THE ONLY NATIONALLY 2844 01:46:07,243 --> 01:46:09,646 REP ACCEPTIVE LONGITUDAL STUDY 2845 01:46:09,646 --> 01:46:11,180 WITH SOCIAL, MENISCAL AND 2846 01:46:11,180 --> 01:46:12,949 PHYSICAL HEALTH RELATED DATA 2847 01:46:12,949 --> 01:46:18,421 FROM ADOLESCENTS TO MID LIFE. 2848 01:46:18,421 --> 01:46:21,057 AD AND ADRD ARE INCREASINGLY 2849 01:46:21,057 --> 01:46:22,191 RECOGNIZED AS UNFOLDING ACROSS 2850 01:46:22,191 --> 01:46:23,860 THE LIFECOURSE, BUT MOST STUDIES 2851 01:46:23,860 --> 01:46:26,896 BEGIN SEVERAL DECADE INTO LIFE, 2852 01:46:26,896 --> 01:46:29,265 WHICH MISSES THE OPPORTUNITY TO 2853 01:46:29,265 --> 01:46:30,700 CAPTURE POTENTIALLY MODIFIABLE 2854 01:46:30,700 --> 01:46:32,101 SOCIAL, PSYCHOLOGICAL AND 2855 01:46:32,101 --> 01:46:34,871 BIOLOGICAL PROCESSES. 2856 01:46:34,871 --> 01:46:36,873 SO WAVE VII WOULD FUND DATA 2857 01:46:36,873 --> 01:46:37,941 COLLECTION, PROCESSING AND 2858 01:46:37,941 --> 01:46:39,409 DISSEMINATION. 2859 01:46:39,409 --> 01:46:41,411 IT'S A COLLABORATION ACROSS 2860 01:46:41,411 --> 01:46:42,812 SEVERAL INSTITUTES AND WOULD 2861 01:46:42,812 --> 01:46:44,781 HAVE MID LIFE HEALTH MARKERS AND 2862 01:46:44,781 --> 01:46:47,850 OUTCOMES TO THOSE COLLECTED IN 2863 01:46:47,850 --> 01:46:49,852 WAVES 1 TO VI AND CONTAINS A 2864 01:46:49,852 --> 01:46:53,356 SPECIAL FOCUS ON AD AND ADRD. 2865 01:46:53,356 --> 01:46:57,226 THERE WOULD BE DATA COLLECTION 2866 01:46:57,226 --> 01:46:59,762 ON PHYSICAL COGNITIVE SENSORY 2867 01:46:59,762 --> 01:47:01,064 FUNCTION, AND HOME HEALTH EXAMS 2868 01:47:01,064 --> 01:47:04,667 WITH BEING A SPLIT COLLECTION, 2869 01:47:04,667 --> 01:47:06,469 ASSAYS OF BLOOD COLLECTED IN 2870 01:47:06,469 --> 01:47:08,671 WAVES V, VI AND VII AND UPDATING 2871 01:47:08,671 --> 01:47:10,573 ON STUDY MORTALITY AND 2872 01:47:10,573 --> 01:47:11,574 DISSEMINATION OF PUBLIC AND 2873 01:47:11,574 --> 01:47:15,845 RESTRICTED ACCESS DATA. 2874 01:47:15,845 --> 01:47:18,848 THE WORK WAS ALOONED WITH NIA'S 2875 01:47:18,848 --> 01:47:20,917 STRATEGIC DIRECTIONS. 2876 01:47:20,917 --> 01:47:23,553 AD AND ADRD IMPLEMENTATION 2877 01:47:23,553 --> 01:47:28,224 MILESTONES IN THE 2019BSR REVIEW 2878 01:47:28,224 --> 01:47:29,158 RECOMMENDATIONS. 2879 01:47:29,158 --> 01:47:32,695 WE AGREED THAT A COOPERATIVE U0E 2880 01:47:32,695 --> 01:47:35,531 COMPLEXITY OF THE DATA 2881 01:47:35,531 --> 01:47:37,333 UNDERTAKEN. 2882 01:47:37,333 --> 01:47:42,372 DISCUSSION FOCUSED ON BOTH THE 2883 01:47:42,372 --> 01:47:46,843 SUCCESS THAT ADD HEALTH HAS HAD 2884 01:47:46,843 --> 01:47:51,280 IN ENGENDERING RESEARCH ON A 2885 01:47:51,280 --> 01:47:58,588 MULTITUDE OF IMPORTANT TOPICS, 2886 01:47:58,588 --> 01:48:05,094 ANDITY ABIAND ITS ABILITY TO IME 2887 01:48:05,094 --> 01:48:05,862 POLICY RECOMMENDATIONS. 2888 01:48:05,862 --> 01:48:07,163 SO I'LL LEAVE IT THERE. 2889 01:48:07,163 --> 01:48:08,264 >> THANK YOU, DR. CASE. 2890 01:48:08,264 --> 01:48:10,833 THE NEXT CONCEPT, ADVANCE AGING 2891 01:48:10,833 --> 01:48:12,235 RESEARCH THROUGH CENTERS FOR 2892 01:48:12,235 --> 01:48:16,005 MEDICARE AND MEDICAID SERVICES, 2893 01:48:16,005 --> 01:48:17,206 CMS, DATA LINKAGE. 2894 01:48:17,206 --> 01:48:19,275 DR. CASE WAS AGAIN THE PRIMARY 2895 01:48:19,275 --> 01:48:21,310 REVIEWER, DR. KHAN THE SECONDARY 2896 01:48:21,310 --> 01:48:22,512 REVIEWER, AND DR. CASE, AGAIN, 2897 01:48:22,512 --> 01:48:24,580 IF YOU COULD BRIEFLY PRESENT THE 2898 01:48:24,580 --> 01:48:25,815 CONCEPT AND THE DISCUSSION. 2899 01:48:25,815 --> 01:48:26,649 >> SURE. 2900 01:48:26,649 --> 01:48:28,985 THERE WAS ENTHUSIASM FOR THIS 2901 01:48:28,985 --> 01:48:31,087 NOTICE OF SPECIAL INTEREST THAT 2902 01:48:31,087 --> 01:48:32,622 WOULD ENCOURAGE THE USE OF 2903 01:48:32,622 --> 01:48:38,661 LINKAGE PROGRAM DATA AND 2904 01:48:38,661 --> 01:48:39,562 NIA-FUNDED STUDIES. 2905 01:48:39,562 --> 01:48:42,198 THE LINKAGE PROGRAM PROVIDES A 2906 01:48:42,198 --> 01:48:43,599 LINKAGE SERVICE TECHNICAL 2907 01:48:43,599 --> 01:48:45,201 ASSISTANCE AND THE CLOUD-BASED 2908 01:48:45,201 --> 01:48:47,270 PLATFORM FOR NIA-FUNDED 2909 01:48:47,270 --> 01:48:49,238 INVESTIGATOR USE. 2910 01:48:49,238 --> 01:48:50,540 IT'S ACCESSIBLE REMOTELY AND 2911 01:48:50,540 --> 01:48:52,341 MEETS FEDERAL DATA SECURITY 2912 01:48:52,341 --> 01:48:54,310 REQUIREMENTS. 2913 01:48:54,310 --> 01:48:56,612 LINKAGE PROGRAM USE WOULD BE 2914 01:48:56,612 --> 01:48:57,914 SUPPORTED THROUGH ADMINISTRATIVE 2915 01:48:57,914 --> 01:49:00,483 SUPPLEMENTS TO LINK NIA-FUNDED 2916 01:49:00,483 --> 01:49:04,053 STUDY DATA TO CMS CLAIMS DATA. 2917 01:49:04,053 --> 01:49:08,491 THE CONCEPT ANTICIPATES FUNDING 2918 01:49:08,491 --> 01:49:11,561 15 NIA-FUNDED RESEARCHERS OVER A 2919 01:49:11,561 --> 01:49:12,428 THREE-YEAR PERIOD. 2920 01:49:12,428 --> 01:49:20,837 IT KDZ W KDZ W ACCORDS WITH MILN 2921 01:49:20,837 --> 01:49:21,838 DATA ACCESSIBILITY AND DATA 2922 01:49:21,838 --> 01:49:23,673 SHARING AND REPRODUCIBILITY AND 2923 01:49:23,673 --> 01:49:25,341 THE 2019 BSR REVIEW 2924 01:49:25,341 --> 01:49:26,709 RECOMMENDATION TO REDUCE 2925 01:49:26,709 --> 01:49:28,444 BARRIERS TO ACCESSING DATA FOR 2926 01:49:28,444 --> 01:49:29,645 RESEARCH. 2927 01:49:29,645 --> 01:49:30,713 SUPPLEMENT AWARDEES WILL BE 2928 01:49:30,713 --> 01:49:32,648 REQUIRED TO SHARE THEIR CMS LINK 2929 01:49:32,648 --> 01:49:33,950 DATA WITH OTHER RESEARCHERS 2930 01:49:33,950 --> 01:49:40,456 THROUGH THE LINKAGE ENCLAVE, AND 2931 01:49:40,456 --> 01:49:41,758 IT'S ANTICIPATED THIS WILL 2932 01:49:41,758 --> 01:49:42,859 REDUCE ADMINISTRATIVE FINANCIAL 2933 01:49:42,859 --> 01:49:44,727 AND IT SECURITY BARRIERS THAT 2934 01:49:44,727 --> 01:49:46,629 MAY INHIBIT STUDIES FROM DATA 2935 01:49:46,629 --> 01:49:48,364 SHARING AND SPEED RESEARCH 2936 01:49:48,364 --> 01:49:49,799 PROGRESS AND ENHANCE THE VALUE 2937 01:49:49,799 --> 01:49:52,368 OF NIA-SUPPORTED RESOURCES. 2938 01:49:52,368 --> 01:49:55,104 IN ADDITION TO THE ENTHUSIASM 2939 01:49:55,104 --> 01:50:00,276 FOR THIS NOSI, IT TRIGGERED 2940 01:50:00,276 --> 01:50:01,043 DISCUSSION IN THE COUNCIL 2941 01:50:01,043 --> 01:50:03,780 OUTSIDE THE PURVIEW OF THIS NOSI 2942 01:50:03,780 --> 01:50:06,916 OF ENCOURAGING NIA TO CONTINUE 2943 01:50:06,916 --> 01:50:09,852 TO ENCOURAGE CMS TO RELEASE DATA 2944 01:50:09,852 --> 01:50:11,287 FOR RESEARCH IN A MORE TIMELY 2945 01:50:11,287 --> 01:50:18,361 FASHION. 2946 01:50:18,361 --> 01:50:18,995 THAT'S ALL I HAVE. 2947 01:50:18,995 --> 01:50:20,062 >> THANK YOU, DR. CASE. 2948 01:50:20,062 --> 01:50:22,365 THE NEXT CONCEPT IS ARTIFICIAL 2949 01:50:22,365 --> 01:50:23,332 INTELLIGENCE AND TECHNOLOGY 2950 01:50:23,332 --> 01:50:24,500 COLLABORATORY. 2951 01:50:24,500 --> 01:50:26,235 NANCY LUNDEBJERG IS THE PRIMARY 2952 01:50:26,235 --> 01:50:28,871 REVIEWER, DR. CRUZ THE SECONDARY 2953 01:50:28,871 --> 01:50:30,006 REVIEWER, AND NANCY, IF YOU 2954 01:50:30,006 --> 01:50:31,207 COULD PRESENT THE CONCEPT AND 2955 01:50:31,207 --> 01:50:32,642 DISCUSSION. 2956 01:50:32,642 --> 01:50:35,912 >> THERE WAS HIGH ENTHUSIASM FOR 2957 01:50:35,912 --> 01:50:38,147 THIS CONCEPT, WHICH IS A RENEWAL 2958 01:50:38,147 --> 01:50:41,651 OF AN EXISTING PROGRAM, THE 2959 01:50:41,651 --> 01:50:43,753 NIA'S ARTIFICIAL INTELLIGENCE 2960 01:50:43,753 --> 01:50:46,155 AND TECHNOLOGY COLLABORATIVE. 2961 01:50:46,155 --> 01:50:48,024 THE CONCEPT AND RENEWAL ARE IN 2962 01:50:48,024 --> 01:50:49,358 LINE WITH NIA PRIORITIES IN THIS 2963 01:50:49,358 --> 01:50:49,826 AREA. 2964 01:50:49,826 --> 01:50:52,128 THERE WAS A GREAT DEAL OF INPUT 2965 01:50:52,128 --> 01:50:54,130 SOUGHT ACROSS THE DIVISIONS AND 2966 01:50:54,130 --> 01:50:56,065 FROM THE WORKING GROUP ON 2967 01:50:56,065 --> 01:50:57,400 ARTIFICIAL INTELLIGENCE THAT 2968 01:50:57,400 --> 01:51:02,438 WENT INTO THE DEVELOPMENT OF 2969 01:51:02,438 --> 01:51:03,873 THIS CONCEPT, INCLUDING EACH OF 2970 01:51:03,873 --> 01:51:06,976 THE DIVISIONS IDENTIFYING A 2971 01:51:06,976 --> 01:51:09,078 PRIORITY AREA FOR RESEARCH BY 2972 01:51:09,078 --> 01:51:11,447 THIS PARTICULAR COLLABORATIVE. 2973 01:51:11,447 --> 01:51:17,086 THE PROPOSAL IS STRUCTURED IN 2974 01:51:17,086 --> 01:51:18,821 PRETTY MUCH THE SAME WAY AS THE 2975 01:51:18,821 --> 01:51:20,923 EXISTING PROGRAM, SO IT'S A P30 2976 01:51:20,923 --> 01:51:22,825 COMBINED WITH A U24 COORDINATING 2977 01:51:22,825 --> 01:51:24,460 CENTER. 2978 01:51:24,460 --> 01:51:28,130 THE PROPOSAL WAS TO INCREASE 2979 01:51:28,130 --> 01:51:30,166 POTENTIALLY FUND UP TO FOUR 2980 01:51:30,166 --> 01:51:30,633 P30s. 2981 01:51:30,633 --> 01:51:34,237 THERE ARE THREE RIGHT NOW. 2982 01:51:34,237 --> 01:51:35,238 THERE'S ATTENTION WITHIN THIS 2983 01:51:35,238 --> 01:51:36,739 CONCEPT TO PEOPLE LIVING WITH 2984 01:51:36,739 --> 01:51:39,208 ALZHEIMER'S DISEASE AND RELATED 2985 01:51:39,208 --> 01:51:42,511 DEMENTIAS, AND DISCUSSION ON 2986 01:51:42,511 --> 01:51:43,813 COUNCIL WAS ESSENTIALLY THAT WE 2987 01:51:43,813 --> 01:51:45,014 SHOULD MOVE FORWARD WITH THIS 2988 01:51:45,014 --> 01:51:50,219 WITH HIGH ENTHUSIASM. 2989 01:51:50,219 --> 01:51:50,853 >> THANK YOU. 2990 01:51:50,853 --> 01:51:52,288 THE NEXT CONCEPT IS DEMENTIA 2991 01:51:52,288 --> 01:51:55,024 CARE AND CAREGIVER SUPPORT, 2992 01:51:55,024 --> 01:51:57,360 INTERVENTION RESEARCH STAGE ONE 2993 01:51:57,360 --> 01:51:58,227 ONLY. 2994 01:51:58,227 --> 01:52:02,598 DR. REUBEN WAS PRIMARY REVIEWER, 2995 01:52:02,598 --> 01:52:03,966 DR. INOUYE THE SECONDARY 2996 01:52:03,966 --> 01:52:06,602 REVIEWER, AND DR. REUBEN, IF YOU 2997 01:52:06,602 --> 01:52:08,004 COULD PRESENT THE CONCEPT AND 2998 01:52:08,004 --> 01:52:08,537 THE DISCUSSION. 2999 01:52:08,537 --> 01:52:10,072 >> YOU'RE GOING TO GET A SET OF 3000 01:52:10,072 --> 01:52:11,540 BOOK ENDS HERE BECAUSE THEY'RE 3001 01:52:11,540 --> 01:52:12,875 BOTH RELATED TO THE SAME TOPIC. 3002 01:52:12,875 --> 01:52:14,644 ONE IS ON STAGE I, WHICH IS 3003 01:52:14,644 --> 01:52:19,382 EARLY RESEARCH IN THE 3004 01:52:19,382 --> 01:52:20,316 DISSEMINATION SEQUENCE, AND 3005 01:52:20,316 --> 01:52:22,685 STAGE I RESEARCH ENCOMPASSES ALL 3006 01:52:22,685 --> 01:52:24,687 ACTIVITIES RELATED TO THE 3007 01:52:24,687 --> 01:52:26,222 CREATION AND PRELIMINARY TESTING 3008 01:52:26,222 --> 01:52:30,359 OF NEW BEHAVIORAL INTERVENTIONS. 3009 01:52:30,359 --> 01:52:32,828 A NOFO OF THIS TYPE IS VERY 3010 01:52:32,828 --> 01:52:34,463 EXCITING FROM MY PERSPECTIVE, 3011 01:52:34,463 --> 01:52:36,198 THERE'S A LOT OF ENTHUSIASM 3012 01:52:36,198 --> 01:52:40,336 ABOUT IT, BECAUSE IT STIMULATES 3013 01:52:40,336 --> 01:52:41,070 INNOVATION BUT REQUIRES A 3014 01:52:41,070 --> 01:52:43,339 CERTAIN AMOUNT OF SPECIFIED 3015 01:52:43,339 --> 01:52:44,040 RIGOR. 3016 01:52:44,040 --> 01:52:49,946 NOT ALL OF THESE INTERVENTIONS, 3017 01:52:49,946 --> 01:52:51,080 FUNDED GRANTS WILL ACTUALLY MAKE 3018 01:52:51,080 --> 01:52:52,715 TO LATER STAGES, BUT THIS IS 3019 01:52:52,715 --> 01:52:55,651 REALLY THE INCUBATOR FOR 3020 01:52:55,651 --> 01:52:56,585 PROMISING INTERVENTIONS THAT 3021 01:52:56,585 --> 01:53:00,423 WILL SUBSEQUENTLY GET LARGER AND 3022 01:53:00,423 --> 01:53:02,925 MORE DEFINITIVE STUDIES. 3023 01:53:02,925 --> 01:53:04,827 SO THERE WAS A LOT OF ENTHUSIASM 3024 01:53:04,827 --> 01:53:05,728 FOR THIS. 3025 01:53:05,728 --> 01:53:08,130 IT WOULD GO THROUGH AN R34 3026 01:53:08,130 --> 01:53:12,835 MECHANISM WHICH IS UP TO 3027 01:53:12,835 --> 01:53:14,036 $450,000 OVER THREE YEARS, AND 3028 01:53:14,036 --> 01:53:15,404 THAT WOULD BE ENOUGH TO REALLY 3029 01:53:15,404 --> 01:53:18,641 GET SOME PRELIMINARY DATA TO 3030 01:53:18,641 --> 01:53:20,876 MOVE ON TO MORE ADVANCED TRIALS 3031 01:53:20,876 --> 01:53:24,313 AND EFFICACY AND EFFECTIVENESS. 3032 01:53:24,313 --> 01:53:25,848 SO THERE WAS A LOT OF ENTHUSIASM 3033 01:53:25,848 --> 01:53:28,818 ABOUT THIS. 3034 01:53:28,818 --> 01:53:30,353 >> THANK YOU, AND TO CONTINUE 3035 01:53:30,353 --> 01:53:34,857 WITH THIS DEMENTIA CARE AND 3036 01:53:34,857 --> 01:53:36,292 CAREGIVER SUPPORT INTERVENTION 3037 01:53:36,292 --> 01:53:43,799 RESEARCH STAGE II THROUGH V, DR. 3038 01:53:43,799 --> 01:53:45,968 >> SO THESE ARE THE SECOND END 3039 01:53:45,968 --> 01:53:47,870 OF THE DESK SET. 3040 01:53:47,870 --> 01:53:49,438 IT'S ABOUT THE EFFECTIVENESS AND 3041 01:53:49,438 --> 01:53:52,174 EFFICACY OF RESEARCH AND 3042 01:53:52,174 --> 01:53:53,809 DISSEMINATION IN STAGES II 3043 01:53:53,809 --> 01:53:55,611 THROUGH V, AND CURRENTLY WE HAVE 3044 01:53:55,611 --> 01:53:58,781 VERY FEW OF THESE WELL DESIGNED 3045 01:53:58,781 --> 01:54:01,217 ADEQUATELY POWERED TRIALS AND 3046 01:54:01,217 --> 01:54:04,754 BEHALF YO YORL INTERVENTIONS FOR 3047 01:54:04,754 --> 01:54:06,088 DEMENTIA AND CAREGIVER SUPPORT. 3048 01:54:06,088 --> 01:54:10,059 THIS IS ACTUALLY A REISSUE OF 3049 01:54:10,059 --> 01:54:16,866 THE OLD PAR21307 AND 21308 AND 3050 01:54:16,866 --> 01:54:21,837 OFFERS A R61 INVERTING TO 3051 01:54:21,837 --> 01:54:23,139 R33 MECHANISM, WHICH 3052 01:54:23,139 --> 01:54:24,673 DEMONSTRATES BOTH FEASIBILITY 3053 01:54:24,673 --> 01:54:28,244 AND THEN CONDUCTS A CLINICAL 3054 01:54:28,244 --> 01:54:29,211 TRIAL. 3055 01:54:29,211 --> 01:54:30,679 SO THIS IS A VERY NICE MECHANISM 3056 01:54:30,679 --> 01:54:32,281 TO GO FROM THE EARLY STAGES TO 3057 01:54:32,281 --> 01:54:36,052 THEN LATER STAGES. 3058 01:54:36,052 --> 01:54:37,386 SO THIS WAS ALSO RECEIVED VERY 3059 01:54:37,386 --> 01:54:42,525 WELL BY COUNCIL YESTERDAY, AND 3060 01:54:42,525 --> 01:54:45,094 WE'D LIKE TO MOVE FORWARD. 3061 01:54:45,094 --> 01:54:45,728 >> THANK YOU. 3062 01:54:45,728 --> 01:54:47,063 THE NEXT CONCEPT IS SOCIAL, 3063 01:54:47,063 --> 01:54:48,697 BEHAVIORAL AND ECONOMIC COVID 3064 01:54:48,697 --> 01:54:49,565 COORDINATING CENTER. 3065 01:54:49,565 --> 01:54:53,335 DR. REUBEN IS THE PRIMARY 3066 01:54:53,335 --> 01:54:54,870 REVIEWER, DR. ASTHANA IS THE 3067 01:54:54,870 --> 01:54:55,704 SECONDARY REVIEWER. 3068 01:54:55,704 --> 01:54:59,308 >> THIS IS WHAT THEY CALL A HAT 3069 01:54:59,308 --> 01:54:59,508 TRICK. 3070 01:54:59,508 --> 01:55:02,711 THREE IN A ROW IN HOCKEY. 3071 01:55:02,711 --> 01:55:06,882 SO THIS IS SOCIAL BEHAVIOR AND 3072 01:55:06,882 --> 01:55:09,018 ECONOMIC COVID COORDINATING 3073 01:55:09,018 --> 01:55:09,452 CENTER. 3074 01:55:09,452 --> 01:55:12,822 ONCE AGAIN, THIS IS A RENEWAL OF 3075 01:55:12,822 --> 01:55:15,991 A PREVIOUS NOFO. 3076 01:55:15,991 --> 01:55:18,928 THE JUSTIFICATION THAT THE STAFF 3077 01:55:18,928 --> 01:55:19,962 PROVIDED WAS VERY INTERESTING. 3078 01:55:19,962 --> 01:55:22,731 IT CITED THE CONVERGING OF LIFE 3079 01:55:22,731 --> 01:55:27,303 EXPECTANCY BETWEEN 2001 AND 3080 01:55:27,303 --> 01:55:28,938 2019, WHITE AND BLACK AMERICANS, 3081 01:55:28,938 --> 01:55:33,843 BUT DURING COVID, THERE WAS A 3082 01:55:33,843 --> 01:55:35,544 REVERSAL OF THIS TREND, WORSENED 3083 01:55:35,544 --> 01:55:37,746 LIFE SPEKD SPECT SEE FROM 3084 01:55:37,746 --> 01:55:38,948 MINORITY GROUPS FOR THE ONSET OF 3085 01:55:38,948 --> 01:55:39,482 COVID. 3086 01:55:39,482 --> 01:55:40,616 THIS COORDINATING CENTER HAS 3087 01:55:40,616 --> 01:55:43,052 BEEN IN OPERATION WITHIN THREE 3088 01:55:43,052 --> 01:55:46,655 YEARS HAS ALREADY CREATED A 3089 01:55:46,655 --> 01:55:48,724 COVID MEASURE ARCHIVE. 3090 01:55:48,724 --> 01:55:50,126 COMMON ELEMENTS FOR DATA 3091 01:55:50,126 --> 01:55:53,829 MITIGATION POLICIES, AWARDED 3092 01:55:53,829 --> 01:55:54,830 PILOTS AND DISSEMINATED 3093 01:55:54,830 --> 01:55:55,364 FINDINGS. 3094 01:55:55,364 --> 01:55:56,499 CONTINUATION OF THE COORDINATING 3095 01:55:56,499 --> 01:55:59,468 CENTER WILL FOSTER CONTINUED 3096 01:55:59,468 --> 01:56:02,972 COORDINATION ACROSS PROJECTS AND 3097 01:56:02,972 --> 01:56:04,673 WILL EXAMINE LONGER TERM ISSUES 3098 01:56:04,673 --> 01:56:07,943 OF THE PANDEMIC ASSOCIATED 3099 01:56:07,943 --> 01:56:08,277 POLICIES. 3100 01:56:08,277 --> 01:56:09,912 LTION PROVIDE AVENUE FOR RAPID 3101 01:56:09,912 --> 01:56:12,948 RESPONSE TO URGENT WORKSHOPS, 3102 01:56:12,948 --> 01:56:15,151 PILOT RESEARCH AND NIH POLICY 3103 01:56:15,151 --> 01:56:20,823 DATA NEEDS. 3104 01:56:20,823 --> 01:56:22,625 IT'S WELL-FUNDED BY MULTIPLE 3105 01:56:22,625 --> 01:56:25,594 INSTITUTES AND CENTERS SO THE 3106 01:56:25,594 --> 01:56:26,362 NI. 3107 01:56:26,362 --> 01:56:27,463 A'S CONTRIBUTION WILL BE MODEST. 3108 01:56:27,463 --> 01:56:33,035 IT'S A DEAL. 3109 01:56:33,035 --> 01:56:33,569 >> THANK YOU. 3110 01:56:33,569 --> 01:56:35,604 THE NEXT CONCEPT IS 3111 01:56:35,604 --> 01:56:36,172 INTERDISCIPLINARY RESEARCH 3112 01:56:36,172 --> 01:56:40,643 NETWORK ON HOUSING AND HEALTH. 3113 01:56:40,643 --> 01:56:45,514 DR. CRUZ IS PRIMARY REVIEWER, IF 3114 01:56:45,514 --> 01:56:47,049 YOU COULD PLEASE PRESENT THE 3115 01:56:47,049 --> 01:56:47,883 CONCEPT AND DISCUSSION. 3116 01:56:47,883 --> 01:56:50,419 >> SURE, THANK YOU. 3117 01:56:50,419 --> 01:56:51,887 THE PURPOSE OF THIS CONCEPT IS 3118 01:56:51,887 --> 01:56:55,391 TO SUPPORT THE INTERDISCIPLINARY 3119 01:56:55,391 --> 01:56:57,259 RESEARCH NETWORK ON HOUSING AND 3120 01:56:57,259 --> 01:56:58,594 HEALTH. 3121 01:56:58,594 --> 01:57:00,729 THE NETWORK MADE UP OF FEDERAL 3122 01:57:00,729 --> 01:57:02,398 PARTNERS PLANS TO CONVENE 3123 01:57:02,398 --> 01:57:04,133 DIFFERENT COMMUNITIES OF 3124 01:57:04,133 --> 01:57:06,502 RESEARCHERS WITH RELEVANT 3125 01:57:06,502 --> 01:57:08,137 EXPERTISE THROUGH A SERIES OF 3126 01:57:08,137 --> 01:57:10,773 ONGOING MEETINGS AND TRAINING, 3127 01:57:10,773 --> 01:57:14,443 ENCOURAGE THEM TO FORM TEAMS AND 3128 01:57:14,443 --> 01:57:16,745 FUND INNOVATIVE NULL PILOT 3129 01:57:16,745 --> 01:57:18,614 PROJECTS WHICH THROUGH ONGOING 3130 01:57:18,614 --> 01:57:20,449 TRAINING, SUPPORT AND NETWORKING 3131 01:57:20,449 --> 01:57:22,418 CAN FORM THE BASIS FOR LARGER 3132 01:57:22,418 --> 01:57:25,487 FUTURE PROJECTS. 3133 01:57:25,487 --> 01:57:27,122 ONE OF THE COCHALLENGES FACING 3134 01:57:27,122 --> 01:57:28,524 HOUSING RESEARCHERS PUBLIC 3135 01:57:28,524 --> 01:57:31,594 HEALTH RESEARCHERS AND AWING 3136 01:57:31,594 --> 01:57:32,895 RESEARCHERS IS THAT OFTEN THEY 3137 01:57:32,895 --> 01:57:35,097 DON'T WORK WITH ONE ANOTHER. 3138 01:57:35,097 --> 01:57:37,866 THEY DON'T HAVE A COORDINATED 3139 01:57:37,866 --> 01:57:40,536 INFRASTRUCTURE DESPITE MULTIPLE 3140 01:57:40,536 --> 01:57:41,704 ORGANIZATIONS EXAMINING THE 3141 01:57:41,704 --> 01:57:43,839 IMPLICATIONS OF HOUSING. 3142 01:57:43,839 --> 01:57:46,575 THE PROPOSE THE NETWORK WOULD 3143 01:57:46,575 --> 01:57:49,979 PROVIDE THIS INFRASTRUCTURE. 3144 01:57:49,979 --> 01:57:50,746 THE NATIONAL INSTITUTE ON AGING 3145 01:57:50,746 --> 01:57:56,151 HAS REQUESTED $100,000 PER YEAR 3146 01:57:56,151 --> 01:57:57,486 FOR FIVE YEARS, THE ICO AND 3147 01:57:57,486 --> 01:58:02,324 SCIENTIFIC DIRECTION. 3148 01:58:02,324 --> 01:58:08,697 >> THANK YOU, DR. CRUZ. 3149 01:58:08,697 --> 01:58:11,100 THE NEXT CONCEPT IS 3150 01:58:11,100 --> 01:58:11,967 CLINICIAN-SCIENTIST 3151 01:58:11,967 --> 01:58:13,936 TRANSDISCIPLINARY AGING RESEARCH 3152 01:58:13,936 --> 01:58:20,909 OR CLINSTAR COORDINATING CENTER. 3153 01:58:20,909 --> 01:58:21,877 DR. ASTHANA, IF YOU COULD PLEASE 3154 01:58:21,877 --> 01:58:22,878 PRESENT. 3155 01:58:22,878 --> 01:58:24,380 >> THANK YOU. 3156 01:58:24,380 --> 01:58:27,950 THIS CONCEPT RECEIVED 3157 01:58:27,950 --> 01:58:28,684 ENTHUSIASTIC SUPPORT FROM THE 3158 01:58:28,684 --> 01:58:28,951 COUNCIL. 3159 01:58:28,951 --> 01:58:30,252 THE CONCEPT REQUESTS RENEWAL OF 3160 01:58:30,252 --> 01:58:34,590 A HIGHLY SUCCESSFUL NIA FUNDED 3161 01:58:34,590 --> 01:58:37,760 TRAINING PROGRAM CALLED CLINSTAR 3162 01:58:37,760 --> 01:58:40,929 WHICH HAS OVER THE YEARS TRAINED 3163 01:58:40,929 --> 01:58:45,801 A NUMBER OF CLINICIANS BECOME 3164 01:58:45,801 --> 01:58:50,172 LEADER IN AGING RESEARCH. 3165 01:58:50,172 --> 01:58:51,607 IT HAS EXPANDED SIGNIFICANTLY 3166 01:58:51,607 --> 01:58:52,941 ACROSS THE COUNTRY INCLUDING AT 3167 01:58:52,941 --> 01:58:54,276 INSTITUTIONS THAT MAY NOT BE 3168 01:58:54,276 --> 01:58:57,880 WELL RESOURCED IN GERONTOLOGY 3169 01:58:57,880 --> 01:58:58,981 RESEARCH. 3170 01:58:58,981 --> 01:59:00,149 FURTHERMORE THE FIELD OF AGING 3171 01:59:00,149 --> 01:59:01,350 RESEARCH IS REQUIRING 3172 01:59:01,350 --> 01:59:05,387 MULTIDISCIPLINARY APPROACH 3173 01:59:05,387 --> 01:59:06,488 COORDINATION AND COLLABORATION 3174 01:59:06,488 --> 01:59:08,324 AMONG MULTIPLE DISCIPLINES AND 3175 01:59:08,324 --> 01:59:10,059 INTEGRATION OF EXPERTISE TO 3176 01:59:10,059 --> 01:59:14,430 UNDERSTAND THE COMPLEXITY OF 3177 01:59:14,430 --> 01:59:16,732 AGING ASSOCIATED DISEASES. 3178 01:59:16,732 --> 01:59:18,534 SO THE RENEWAL OF THIS PROPOSAL 3179 01:59:18,534 --> 01:59:19,535 WILL PROVIDE OUTSTANDING 3180 01:59:19,535 --> 01:59:21,937 RESOURCES SO EARLY STAGE 3181 01:59:21,937 --> 01:59:23,605 CLINICIANS TO EXPLAIN THE 3182 01:59:23,605 --> 01:59:25,174 INTEREST IN AGING RESEARCH. 3183 01:59:25,174 --> 01:59:26,909 SO THE CLINSTAR ORIGINALLY WAS 3184 01:59:26,909 --> 01:59:31,847 FUNDED IN 2019 THROUGH A U24 3185 01:59:31,847 --> 01:59:33,449 MECHANISM AND AT THAT TIME IT 3186 01:59:33,449 --> 01:59:34,383 INVOLVED THE AMERICAN FEDERATION 3187 01:59:34,383 --> 01:59:38,053 FOR AGING RESEARCH, THE YALE AND 3188 01:59:38,053 --> 01:59:42,057 HOPKINS UNIVERSITY AND UCLA. 3189 01:59:42,057 --> 01:59:46,128 THE PRESENT APPLICATION ONCE 3190 01:59:46,128 --> 01:59:47,763 RENEWED WILL REALLY CONTINUE THE 3191 01:59:47,763 --> 01:59:48,964 NIA EFFORTS TO TRAIN THE NEXT 3192 01:59:48,964 --> 01:59:52,534 GENERATION OF 3193 01:59:52,534 --> 01:59:53,635 CLINICIAN-SCIENTISTS IN AGING 3194 01:59:53,635 --> 01:59:57,339 RESEARCH WHICH WE ALL BELIEVE IS 3195 01:59:57,339 --> 01:59:59,441 PIVOTAL. 3196 01:59:59,441 --> 02:00:02,878 IT WAS APPROVED AND RECEIVED 3197 02:00:02,878 --> 02:00:06,115 SIGNIFICANT MAJOR ENTHUSIASM 3198 02:00:06,115 --> 02:00:06,749 FROM THE COUNCIL. 3199 02:00:06,749 --> 02:00:08,350 >> THANKS, SANJAY. 3200 02:00:08,350 --> 02:00:11,253 THE NEXT CONCEPT IS CARING FOR 3201 02:00:11,253 --> 02:00:12,588 COMPLEX OLDER ADULTS THROUGH 3202 02:00:12,588 --> 02:00:13,455 ELECTRONIC HEALTH RECORD 3203 02:00:13,455 --> 02:00:16,258 DASHBOARD CALLED COATED. 3204 02:00:16,258 --> 02:00:16,825 NANCY, IF YOU COULD PLEASE 3205 02:00:16,825 --> 02:00:18,660 PRESENT THE CONCEPT AND 3206 02:00:18,660 --> 02:00:18,961 DISCUSSION. 3207 02:00:18,961 --> 02:00:21,163 >> SURE. 3208 02:00:21,163 --> 02:00:22,598 COATED WAS A NEW CONCEPT 3209 02:00:22,598 --> 02:00:24,500 PROPOSAL FOR A U24 COOPERATIVE 3210 02:00:24,500 --> 02:00:26,268 AGREEMENT THAT WILL SUPPORT 3211 02:00:26,268 --> 02:00:28,537 COLLABORATIONS WITH ELECTRONIC 3212 02:00:28,537 --> 02:00:31,340 HEALTH RECORD VENDORS VIA U24 3213 02:00:31,340 --> 02:00:32,007 MECHANISM. 3214 02:00:32,007 --> 02:00:36,178 THE APPROACH WAS -- PARTNERSHIPS 3215 02:00:36,178 --> 02:00:40,282 WITH EHR VENDORS AND HEALTHCARE 3216 02:00:40,282 --> 02:00:42,818 SYSTEMS TO DEPLOY DATA ANALYTICS 3217 02:00:42,818 --> 02:00:43,886 AND DASHBOARDS ACROSS THE 3218 02:00:43,886 --> 02:00:45,721 COUNTRY TO IMPROVE OLDER ADULTS 3219 02:00:45,721 --> 02:00:46,488 HEALTHCARE. 3220 02:00:46,488 --> 02:00:47,589 WOW, THAT'S A MOUTHFUL. 3221 02:00:47,589 --> 02:00:49,324 THIS INITIATIVE WOULD ADDRESS 3222 02:00:49,324 --> 02:00:51,160 THE NEEDS OF INDIVIDUALS AT RISK 3223 02:00:51,160 --> 02:00:55,197 BY CONDUCTING RESEARCH AND 3224 02:00:55,197 --> 02:00:55,964 BUILDING INFRASTRUCTURE WITH A 3225 02:00:55,964 --> 02:00:57,065 FOCUS ON PRIMARY CARE. 3226 02:00:57,065 --> 02:00:58,767 THE CONCEPT ADDRESSES AN 3227 02:00:58,767 --> 02:00:59,635 IMPORTANT AREA IN PATIENT CARE 3228 02:00:59,635 --> 02:01:01,603 AND PROPOSES TO DO SO IN 3229 02:01:01,603 --> 02:01:04,940 PARTNERSHIP WITH THE PRIVATE 3230 02:01:04,940 --> 02:01:05,207 SECTOR. 3231 02:01:05,207 --> 02:01:09,578 I WOULD SAY THAT COUNCIL 3232 02:01:09,578 --> 02:01:13,248 DISCUSSION WAS SPLIT INTO TWO 3233 02:01:13,248 --> 02:01:14,049 SORT OF KEY POINTS TO THE 3234 02:01:14,049 --> 02:01:16,285 PROGRAM STAFF. 3235 02:01:16,285 --> 02:01:19,087 ONE WAS AROUND THE EXPERIENCE -- 3236 02:01:19,087 --> 02:01:20,122 MAINLY THE LIVED EXPERIENCE OF 3237 02:01:20,122 --> 02:01:22,825 WORKING WITH EHR VENDORS THAT 3238 02:01:22,825 --> 02:01:30,098 MANY OF US HAVE OBSERVED SO THAT 3239 02:01:30,098 --> 02:01:31,400 THE CONCEPT -- I THINK FEEDBACK 3240 02:01:31,400 --> 02:01:32,501 FROM COUNCIL WAS THAT THE 3241 02:01:32,501 --> 02:01:33,502 CONCEPT SHOULD ADDRESS THAT IN 3242 02:01:33,502 --> 02:01:34,102 SOME WAY. 3243 02:01:34,102 --> 02:01:37,272 AND THEN THE SECOND WAS A POINT 3244 02:01:37,272 --> 02:01:39,141 THAT BOTH DR. GREENSPAN AND I 3245 02:01:39,141 --> 02:01:41,510 MADE IN OUR COMMENTS, WHICH WAS 3246 02:01:41,510 --> 02:01:45,013 THE IMPORTANCE IN ANY EFFORT 3247 02:01:45,013 --> 02:01:46,114 LIKE THIS OF INCLUDING PEOPLE 3248 02:01:46,114 --> 02:01:52,321 WITH LIVED EXPERIENCE AND THEIR 3249 02:01:52,321 --> 02:01:53,956 CAREGIVERS IN STAKEHOLDER 3250 02:01:53,956 --> 02:01:55,424 ADVISORY GROUPS AND AS PART OF 3251 02:01:55,424 --> 02:01:57,793 DESIGN TEAMS. 3252 02:01:57,793 --> 02:01:59,194 >> THANK YOU, NANCY. 3253 02:01:59,194 --> 02:02:02,030 THE NEXT CONCEPT IS THE NATIONAL 3254 02:02:02,030 --> 02:02:05,000 ALZHEIMER'S COORDINATING CENTER, 3255 02:02:05,000 --> 02:02:05,767 NACC. 3256 02:02:05,767 --> 02:02:09,137 THE PRIMARY REVIEWER IS 3257 02:02:09,137 --> 02:02:10,672 DR. HULING-HUMMEL, AND SECONDARY 3258 02:02:10,672 --> 02:02:13,709 REVIEWER IS DR. CILIBERTO. 3259 02:02:13,709 --> 02:02:15,010 SO DR. HUM EL, IF YOU COULD 3260 02:02:15,010 --> 02:02:15,878 PLEASE PRESENT THE CONCEPT. 3261 02:02:15,878 --> 02:02:17,412 >> YES, I WAS ASKED TO BE THE 3262 02:02:17,412 --> 02:02:21,617 PRIMARY REVIEWER FOR A NOTICE OF 3263 02:02:21,617 --> 02:02:22,351 FUNDING OPPORTUNITY FOR 2024. 3264 02:02:22,351 --> 02:02:23,752 THE PROJECT THAT I REVIEWED 3265 02:02:23,752 --> 02:02:25,087 REQUESTS A SETASIDE AMOUNT AND 3266 02:02:25,087 --> 02:02:27,289 IT'S TITLED THE NATIONAL 3267 02:02:27,289 --> 02:02:28,757 ALZHEIMER'S COORDINATING CENTER 3268 02:02:28,757 --> 02:02:31,493 OR NACC FOR SHORT. 3269 02:02:31,493 --> 02:02:32,794 THE CENTER LOCATED IN SEATTLE, 3270 02:02:32,794 --> 02:02:35,230 WASHINGTON WAS ESTABLISHED IN 3271 02:02:35,230 --> 02:02:38,267 1999 TO FACILITATE COLLABORATIVE 3272 02:02:38,267 --> 02:02:43,238 RESEARCH AND IT'S THE LARGEST 3273 02:02:43,238 --> 02:02:44,239 AD/ADRD RESOURCE CENTER OF ITS 3274 02:02:44,239 --> 02:02:45,207 KIND IN THE UNITED STATES. 3275 02:02:45,207 --> 02:02:47,943 THIS RENEWAL PROJECT FALLS UNDER 3276 02:02:47,943 --> 02:02:50,112 THE AUSPICES OF THE DIVISION OF 3277 02:02:50,112 --> 02:02:50,879 NEUROSCIENCE. 3278 02:02:50,879 --> 02:02:51,980 DR. ELLIOTT IS THE PRIMARY POINT 3279 02:02:51,980 --> 02:02:53,048 OF CONTACT. 3280 02:02:53,048 --> 02:02:54,550 I CONCUR THAT THE FUNDING OF 3281 02:02:54,550 --> 02:02:58,287 THIS PROJECT IS ESSENTIAL IN 3282 02:02:58,287 --> 02:03:00,088 ORDER TO UP GREAT THE NACC AND 3283 02:03:00,088 --> 02:03:03,725 ITS SATELLITE CENTERS FOR 3284 02:03:03,725 --> 02:03:04,493 AD/ADRC RESEARCH. 3285 02:03:04,493 --> 02:03:06,762 THE NACC IS ON A MISSION TO 3286 02:03:06,762 --> 02:03:08,263 MODERNIZE AND HARMONIZE NOT JUST 3287 02:03:08,263 --> 02:03:09,932 THE OVERALL INFRASTRUCTURE BUT 3288 02:03:09,932 --> 02:03:12,000 ALSO THE TECHNOLOGY NEEDED IN 3289 02:03:12,000 --> 02:03:14,636 ORDER TO PRESERVE THE LONGITUDAL 3290 02:03:14,636 --> 02:03:17,506 DATA IN SEATTLE AS WELL AS THE 3291 02:03:17,506 --> 02:03:19,942 33 ALZHEIMER'S CENTERS AND FOUR 3292 02:03:19,942 --> 02:03:22,144 EXPLORATORY CENTERS ACROSS THE 3293 02:03:22,144 --> 02:03:22,878 UNITED STATES. 3294 02:03:22,878 --> 02:03:25,180 THE NACC HOUSES DATA COLLECTED 3295 02:03:25,180 --> 02:03:29,084 ON OVER 50,000 INDIVIDUALS, 3296 02:03:29,084 --> 02:03:30,752 INCLUDING 18,000 ACTIVE 3297 02:03:30,752 --> 02:03:34,423 PARTICIPANTS. 3298 02:03:34,423 --> 02:03:36,625 ADDITIONALLY 188,000 CLINICAL 3299 02:03:36,625 --> 02:03:39,628 ASSESSMENTS, IT HAS DATA ON 3300 02:03:39,628 --> 02:03:41,430 7,900 NEUROPATHY EXAMS. 3301 02:03:41,430 --> 02:03:43,265 DATA FROM THE NACC HAS BEEN 3302 02:03:43,265 --> 02:03:47,736 CITED IN 1,300 PUBLISHED 3303 02:03:47,736 --> 02:03:48,170 STUDIES. 3304 02:03:48,170 --> 02:03:50,038 I WAS HAPPY TO READ THAT THE 3305 02:03:50,038 --> 02:03:51,340 UPGRADE PROMISES TO EXPAND DATA 3306 02:03:51,340 --> 02:03:53,075 ON PARTICIPANT DIVERSITY, AND 3307 02:03:53,075 --> 02:03:54,710 THIS IS CRITICAL TO OUR 3308 02:03:54,710 --> 02:03:57,012 UNDERSTANDING OF AD/ADRC. 3309 02:03:57,012 --> 02:03:58,313 INCLUDING EARLY DIAGNOSIS AND 3310 02:03:58,313 --> 02:03:59,915 POTENTIAL TREATMENTS. 3311 02:03:59,915 --> 02:04:01,550 ANOTHER KEY COMPONENT OF THE 3312 02:04:01,550 --> 02:04:03,652 PLANS WILL BE TO UPGRADE 3313 02:04:03,652 --> 02:04:04,519 INFORMATICS CAPABILITIES THAT 3314 02:04:04,519 --> 02:04:06,989 WILL PROMOTE EFFICIENT SHARING 3315 02:04:06,989 --> 02:04:08,190 OF DATA IN ACCORDANCE WITH FAIR 3316 02:04:08,190 --> 02:04:09,224 PRINCIPLES. 3317 02:04:09,224 --> 02:04:10,826 THIS UPGRADE WILL BENEFIT 3318 02:04:10,826 --> 02:04:13,095 RESEARCHERS ALL OVER THE WORLD 3319 02:04:13,095 --> 02:04:15,163 BECAUSE NACC DATA IS FREELY 3320 02:04:15,163 --> 02:04:17,165 AVAILABLE TO ALL RESEARCHERS, 3321 02:04:17,165 --> 02:04:19,501 WHICH IN TURN WILL ACCELERATE 3322 02:04:19,501 --> 02:04:20,702 SCIENTIFIC DISCOVERIES. 3323 02:04:20,702 --> 02:04:22,337 THE UPGRADE ALSO AIMS TO 3324 02:04:22,337 --> 02:04:24,072 INTEGRATE BOTH EXISTING AND 3325 02:04:24,072 --> 02:04:26,575 EMERGING DATA STREAMS. 3326 02:04:26,575 --> 02:04:29,011 BECAUSE OF THE COMPLEXITIES AND 3327 02:04:29,011 --> 02:04:30,045 UPGRADES TO INFRASTRUCTURES, 3328 02:04:30,045 --> 02:04:33,682 DATA COLLECTION AND SHARING, AND 3329 02:04:33,682 --> 02:04:38,687 MAKING ALL ADRC CENTERS 3330 02:04:38,687 --> 02:04:40,789 SEARCHABLE, THE PROJECT PLANS TO 3331 02:04:40,789 --> 02:04:43,725 NOT JUST MAINTAIN BUT TO EXPAND 3332 02:04:43,725 --> 02:04:44,292 PEER REVIEWER INVESTIGATOR 3333 02:04:44,292 --> 02:04:44,893 AWARDS. 3334 02:04:44,893 --> 02:04:45,894 THIS EXCITING PROJECT WILL 3335 02:04:45,894 --> 02:04:46,962 REQUIRE EXTRA SUPPORT AND 3336 02:04:46,962 --> 02:04:48,463 INVOLVEMENT FROM NIH STAFF, AND 3337 02:04:48,463 --> 02:04:49,731 THE RESULT WILL FURTHER ADVANCE 3338 02:04:49,731 --> 02:04:52,934 OUR STUDY, OUR UNDERSTANDING OF 3339 02:04:52,934 --> 02:04:55,671 AD/ADRC, WHICH IN TURN SUPPORTS 3340 02:04:55,671 --> 02:04:57,205 RESEARCH THAT LEADS TO NEW 3341 02:04:57,205 --> 02:04:59,041 INTERVENTIONS AND TREATMENTS. 3342 02:04:59,041 --> 02:05:01,143 THERE WAS A GREAT DEAL OF 3343 02:05:01,143 --> 02:05:02,110 ENTHUSIASM FOR THIS PROJECT. 3344 02:05:02,110 --> 02:05:04,413 THANK YOU. 3345 02:05:04,413 --> 02:05:05,947 >> THANK YOU, CYNTHIA. 3346 02:05:05,947 --> 02:05:08,750 OUR NEXT PROPOSAL, THE NATIONAL 3347 02:05:08,750 --> 02:05:09,951 CENTRALIZED REPOSITORY FOR 3348 02:05:09,951 --> 02:05:14,322 ALZHEIMER'S DISEASE AND RELATED 3349 02:05:14,322 --> 02:05:16,391 DEMENTIAS, NCRAD. 3350 02:05:16,391 --> 02:05:17,826 DR. HUANG IS THE PRIMARY 3351 02:05:17,826 --> 02:05:20,128 REVIEWER, DR. BAKER THE 3352 02:05:20,128 --> 02:05:22,197 SECONDARY REVIEWER. 3353 02:05:22,197 --> 02:05:24,366 SO YADONG, IF YOU COULD PLEASE 3354 02:05:24,366 --> 02:05:26,201 PRESENT YOUR COMMENTS AND THE 3355 02:05:26,201 --> 02:05:26,501 DISCUSSION. 3356 02:05:26,501 --> 02:05:30,138 >> THIS CONCEPT PROPOSAL IS 3357 02:05:30,138 --> 02:05:31,640 SPONSORED BY DIVISION OF 3358 02:05:31,640 --> 02:05:32,641 NEUROSCIENCE, AIMING TO SUPPORT 3359 02:05:32,641 --> 02:05:38,413 THE RENEWAL OF THIS NCRAT AD WHH 3360 02:05:38,413 --> 02:05:39,848 STANDS FOR THE NATIONAL 3361 02:05:39,848 --> 02:05:40,882 CENTRALIZED REPOSITORY FOR 3362 02:05:40,882 --> 02:05:43,218 ALZHEIMER'S DISEASE AND RELATED 3363 02:05:43,218 --> 02:05:43,719 DEMENTIA. 3364 02:05:43,719 --> 02:05:47,889 THIS NCRAD IS A CENTRALIZED 3365 02:05:47,889 --> 02:05:50,959 INFRASTRUCTURE FOR NIA FUNDED AD 3366 02:05:50,959 --> 02:05:53,895 AND ADRD RESEARCH BY PROVIDING A 3367 02:05:53,895 --> 02:05:56,398 REPOSITORY THAT CURRENTLY 3368 02:05:56,398 --> 02:05:59,201 SUPPORTS 74 STUDIES INCLUDING 3369 02:05:59,201 --> 02:06:05,440 THESE ADRDs WITH 2 MILLION -- 3370 02:06:05,440 --> 02:06:06,775 ABOUT 126,000 INDIVIDUALS 3371 02:06:06,775 --> 02:06:07,609 INCLUDING 15 DIFFERENT TYPE OF 3372 02:06:07,609 --> 02:06:09,144 SAMPLES. 3373 02:06:09,144 --> 02:06:10,345 THE RENEWAL WILL SUPPORT THE 3374 02:06:10,345 --> 02:06:14,182 CONTINUATION OF THIS CENTRAL 3375 02:06:14,182 --> 02:06:20,522 BIOSPECIMEN REFOS TRI FOR NIH RA 3376 02:06:20,522 --> 02:06:22,824 FUNDED DEMENTIA STUDIES AND IT 3377 02:06:22,824 --> 02:06:23,391 WILL FACILITATE THE SAMPLE 3378 02:06:23,391 --> 02:06:24,893 SHARING TO ALL QUALIFIED 3379 02:06:24,893 --> 02:06:26,094 INVESTIGATORS AS WELL AS A 3380 02:06:26,094 --> 02:06:28,463 BIOMARKER ASSESSMENT LABORATORY 3381 02:06:28,463 --> 02:06:29,898 WHICH AT THE MOMENT IS A 3382 02:06:29,898 --> 02:06:30,866 BIOMARKER RESEARCH WITH HIGH 3383 02:06:30,866 --> 02:06:32,200 QUALITY CONTROL AND 3384 02:06:32,200 --> 02:06:33,168 HARMONIZATION WITH OTHER 3385 02:06:33,168 --> 02:06:35,170 LABORATORIES. 3386 02:06:35,170 --> 02:06:39,274 THE CONCEPT ALSO PROPOSED THIS 3387 02:06:39,274 --> 02:06:40,909 NCRAD AS A BRIDGE LINKING CLINIC 3388 02:06:40,909 --> 02:06:45,814 STUDIES AND BASIC SCIENTIST TO 3389 02:06:45,814 --> 02:06:49,751 ADVANCE THIS AD AND ADRC 3390 02:06:49,751 --> 02:06:52,154 RESEARCH, AND USE AN RFA WITH A 3391 02:06:52,154 --> 02:06:53,355 U24 FUNDING MECHANISM SUPPORTING 3392 02:06:53,355 --> 02:06:54,456 HIGH PRIORITY RESEARCH AREAS. 3393 02:06:54,456 --> 02:06:56,324 DURING THE DISCUSSION, THE 3394 02:06:56,324 --> 02:07:00,796 COUNCIL RECOGNIZED THAT THIS 3395 02:07:00,796 --> 02:07:01,997 NCRAD IS NECESSARY TO THE 3396 02:07:01,997 --> 02:07:05,267 CONTINUED SUPPORT OF MULTIPLE 3397 02:07:05,267 --> 02:07:06,568 LARGE NIA INFRASTRUCTURE 3398 02:07:06,568 --> 02:07:09,838 PROJECTS, INCLUDING THIS 3399 02:07:09,838 --> 02:07:10,605 NATIONAL ALZHEIMER'S 3400 02:07:10,605 --> 02:07:15,844 COORDINATING CENTER, ADSP AND 3401 02:07:15,844 --> 02:07:17,145 CENTER FOR ALZHEIMER'S AND 3402 02:07:17,145 --> 02:07:22,851 RELATED DEMENTIAS, THEREFORE IT 3403 02:07:22,851 --> 02:07:24,553 WAS ENTHUSIASTICALLY YOU 3404 02:07:24,553 --> 02:07:24,820 SUPPORTED. 3405 02:07:24,820 --> 02:07:25,153 >> THANK YOU. 3406 02:07:25,153 --> 02:07:27,289 THE NEXT CONCEPT, 3407 02:07:27,289 --> 02:07:27,956 INTERDISCIPLINARY RESEARCH TO 3408 02:07:27,956 --> 02:07:29,457 UNDERSTAND THE COMPLEX BIOLOGY 3409 02:07:29,457 --> 02:07:31,193 OF RESILIENCE TO ALZHEIMER'S AND 3410 02:07:31,193 --> 02:07:32,727 RELATED DEMENTIA DISEASE RISK. 3411 02:07:32,727 --> 02:07:34,062 THE PRIMARY REVIEWER IS 3412 02:07:34,062 --> 02:07:34,596 DR. INOUYE. 3413 02:07:34,596 --> 02:07:35,964 THE SECONDARY REVIEWER IS 3414 02:07:35,964 --> 02:07:36,832 DR. HUANG. 3415 02:07:36,832 --> 02:07:47,209 AND DR. INEYE, IF INEYE, IF IND 3416 02:07:47,209 --> 02:07:48,510 PLEASE PRESENT THE CONCEPT AND 3417 02:07:48,510 --> 02:07:48,844 DISCUSSION. 3418 02:07:48,844 --> 02:07:49,177 >> SURE. 3419 02:07:49,177 --> 02:07:51,479 SO THIS IS A RENEWAL PROPOSAL 3420 02:07:51,479 --> 02:07:53,081 FOR RENEWING TWO PRIOR RFAs 3421 02:07:53,081 --> 02:07:54,549 WHICH HAVE BEEN VERY SUCCESSFUL 3422 02:07:54,549 --> 02:07:56,685 IIN ADVANCING UNDERSTANDING OF 3423 02:07:56,685 --> 02:07:59,321 MOLECULAR DETERMINANTS OF 3424 02:07:59,321 --> 02:08:00,622 RESILIENCE IN AD, AND THEY HAVE 3425 02:08:00,622 --> 02:08:03,058 ALREADY LED TO THE EXCITING 3426 02:08:03,058 --> 02:08:04,326 DISCOVERY OF NOVEL CANDIDATE 3427 02:08:04,326 --> 02:08:04,659 TARGETS. 3428 02:08:04,659 --> 02:08:06,294 AND THE PROPOSED RENEWAL CONCEPT 3429 02:08:06,294 --> 02:08:09,130 IS GOING TO BUILD ON THIS PRIOR 3430 02:08:09,130 --> 02:08:11,867 WORK AND HOPES TO ADVANCE THE 3431 02:08:11,867 --> 02:08:14,936 DEVELOPMENT OF FURTHER 3432 02:08:14,936 --> 02:08:17,305 RESILIENCE BASED PRECISION PAIR 3433 02:08:17,305 --> 02:08:22,677 THANK YOU TICSTHERAPEUTICS, AGAS 3434 02:08:22,677 --> 02:08:27,515 ON GENOMIC MECHANISTIC METHODS, 3435 02:08:27,515 --> 02:08:28,783 AND I THINK SOME OF THE 3436 02:08:28,783 --> 02:08:30,318 EXCITEMENT AND EXPANSION OF THIS 3437 02:08:30,318 --> 02:08:35,323 RFA ARE TO INTEGRATE 3438 02:08:35,323 --> 02:08:38,193 EPIDEMIOLOGIC GENOMIC AND 3439 02:08:38,193 --> 02:08:39,594 MECHANISTIC RESEARCH WITH NOVEL 3440 02:08:39,594 --> 02:08:40,795 DATA-DRIVEN APPROACHES 3441 02:08:40,795 --> 02:08:42,664 INCORPORATING AI, MACHINE 3442 02:08:42,664 --> 02:08:46,902 LEARNING MECHANISMS. 3443 02:08:46,902 --> 02:08:48,236 SO WE ALL FELT THAT THIS WAS 3444 02:08:48,236 --> 02:08:51,072 VERY EXCITING AND RELEVANT TO 3445 02:08:51,072 --> 02:08:52,908 LOOK AT DETERMINANTS OF 3446 02:08:52,908 --> 02:08:56,077 RESILIENCE, WHICH IS AN 3447 02:08:56,077 --> 02:08:59,581 IMPORTANT AREA TO ADVANCE OUR 3448 02:08:59,581 --> 02:09:02,951 UNDERSTANDING OF AD/ADRC RISK 3449 02:09:02,951 --> 02:09:05,253 ACROSS DIVERSE POPULATIONS. 3450 02:09:05,253 --> 02:09:07,322 IT IS GOING TO BE USING VERY 3451 02:09:07,322 --> 02:09:11,259 ADVANCED METHODOLOGIES, AND ALSO 3452 02:09:11,259 --> 02:09:13,995 SOME CROSS SPECIES WORK AS WELL, 3453 02:09:13,995 --> 02:09:16,598 WHICH WE WERE EXCITED ABOUT. 3454 02:09:16,598 --> 02:09:20,435 THE REVIEWERS AND COUNCILS, 3455 02:09:20,435 --> 02:09:24,039 COUNCILMEMBERS HAD SOME COMMENTS 3456 02:09:24,039 --> 02:09:25,907 THAT WERE MADE AND PROGRAM HAS 3457 02:09:25,907 --> 02:09:26,875 ALREADY RESPONDED THAT THEY'RE 3458 02:09:26,875 --> 02:09:30,378 GOING TO INCORPORATE THOSE 3459 02:09:30,378 --> 02:09:34,049 CHANGES INCLUDING A SPECIFIC 3460 02:09:34,049 --> 02:09:36,952 FOCUS TO INCORPORATE SDOH TO 3461 02:09:36,952 --> 02:09:42,057 MAKE SURE TO INCLUDE CLINICAL 3462 02:09:42,057 --> 02:09:44,125 GERONTOLOGY, EXPERTISE AND ALSO 3463 02:09:44,125 --> 02:09:48,330 KIND OF EXPANDING THE MEDICAL 3464 02:09:48,330 --> 02:09:49,831 POTENTIAL CONTRIBUTIONS TO 3465 02:09:49,831 --> 02:09:53,101 RESILIENCE SUCH AS DELIRIUM. 3466 02:09:53,101 --> 02:09:54,202 SO WE WERE GENERALLY VERY 3467 02:09:54,202 --> 02:09:56,938 SUPPORTIVE OF THIS PROPOSAL AND 3468 02:09:56,938 --> 02:09:57,806 VOTED THAT IT SHOULD MOVE 3469 02:09:57,806 --> 02:09:58,073 FORWARD. 3470 02:09:58,073 --> 02:10:02,077 THANK YOU. 3471 02:10:02,077 --> 02:10:02,744 >> THANK YOU, SHARON. 3472 02:10:02,744 --> 02:10:05,480 THE NEXT CONCEPT IS 3473 02:10:05,480 --> 02:10:06,348 INSTITUTIONAL RESEARCH TRAINING 3474 02:10:06,348 --> 02:10:07,615 AWARD FOR AD/ADRC AND AGING 3475 02:10:07,615 --> 02:10:08,850 RESEARCH IN LOW AND MIDDLE 3476 02:10:08,850 --> 02:10:12,020 INCOME COUNTRIES. 3477 02:10:12,020 --> 02:10:13,221 LMICS. 3478 02:10:13,221 --> 02:10:15,724 THE PRIMARY REVIEWER WAS 3479 02:10:15,724 --> 02:10:18,326 DR. SCHNEIDER AND THE SECONDARY 3480 02:10:18,326 --> 02:10:20,962 REVIEWER, DR. ASTHANA. 3481 02:10:20,962 --> 02:10:23,131 IF YOU COULD PLEASE PRESENT THE 3482 02:10:23,131 --> 02:10:24,099 PROPOSAL AND YOUR DISCUSSION. 3483 02:10:24,099 --> 02:10:27,102 >> SO THIS IS A NOFO, NOTICE OF 3484 02:10:27,102 --> 02:10:28,470 FUNDING OPPORTUNITY FOR A D43, 3485 02:10:28,470 --> 02:10:29,904 WHICH IS AN INTERNATIONAL 3486 02:10:29,904 --> 02:10:35,477 TRAINING GRANT THAT'S TRANS NIA 3487 02:10:35,477 --> 02:10:38,413 AGING AND IT'S A PRIORITY 3488 02:10:38,413 --> 02:10:40,248 BECAUSE OF THE AGING POPULATION 3489 02:10:40,248 --> 02:10:41,583 AND LOW MIDDLE INCOME COUNTRIES 3490 02:10:41,583 --> 02:10:43,018 AND THE NEED FOR RESEARCH. 3491 02:10:43,018 --> 02:10:46,588 IT WAS KEY RECOMMENDATION AND 3492 02:10:46,588 --> 02:10:47,255 HAS ALREADY BEEN INITIATING 3493 02:10:47,255 --> 02:10:49,224 EFFORTS IN THIS REGARD BUT 3494 02:10:49,224 --> 02:10:53,061 THERE'S STILL A NEED FOR MORE 3495 02:10:53,061 --> 02:10:55,330 TRAINING OF WORK STAFF WITHIN 3496 02:10:55,330 --> 02:10:56,865 THESE LOW MIDDLE INCOME 3497 02:10:56,865 --> 02:10:57,766 COUNTRIES, AND THERE'S BEEN A 3498 02:10:57,766 --> 02:10:59,067 LOT OF -- THERE'S BEEN A HIGH 3499 02:10:59,067 --> 02:11:01,336 INTEREST IN THE LOW AND MIDDLE 3500 02:11:01,336 --> 02:11:02,203 INCOME COUNTRIES. 3501 02:11:02,203 --> 02:11:03,872 NIH HAS BEEN RECEIVING A LOT OF 3502 02:11:03,872 --> 02:11:05,306 INCREASED INQUIRIES REGARDING 3503 02:11:05,306 --> 02:11:08,543 BUILDING THIS INFRASTRUCTURE. 3504 02:11:08,543 --> 02:11:10,612 SO THIS LEVERAGES CURRENT NIA 3505 02:11:10,612 --> 02:11:12,680 INVESTMENT IN LOW AND MIDDLE 3506 02:11:12,680 --> 02:11:13,982 INCOME COUNTRIES RESEARCH 3507 02:11:13,982 --> 02:11:15,650 TRAINING PROGRAMS IN THE 3508 02:11:15,650 --> 02:11:16,518 OVERARCHING GOALS TO BUILD 3509 02:11:16,518 --> 02:11:18,053 CAPACITY BUT WILL ALSO SUPPORT 3510 02:11:18,053 --> 02:11:18,820 COLLABORATIONS BETWEEN U.S. AND 3511 02:11:18,820 --> 02:11:20,422 THESE OTHER COUNTRIES FOR 3512 02:11:20,422 --> 02:11:21,222 SUSTAINABLE RESEARCH. 3513 02:11:21,222 --> 02:11:23,758 IT WILL STRENGTHEN THE ABILITY 3514 02:11:23,758 --> 02:11:25,827 OF THE LOW MIDDLE INCOME COUNTRY 3515 02:11:25,827 --> 02:11:28,329 INSTITUTIONS TO STRENGTHEN 3516 02:11:28,329 --> 02:11:29,264 CONTRIBUTIONS AND ESTABLISH 3517 02:11:29,264 --> 02:11:30,832 INTERNATIONAL TRAINING PROGRAMS. 3518 02:11:30,832 --> 02:11:32,367 THE EXPECTATIONS TO BUILD 3519 02:11:32,367 --> 02:11:35,537 TRAINING PROGRAMS TO INCREASE 3520 02:11:35,537 --> 02:11:38,039 TRAINING IN AGING 3521 02:11:38,039 --> 02:11:39,040 COLLABORATIONS, TRAINING 3522 02:11:39,040 --> 02:11:39,908 EXCHANGES, JOINT RESEARCH 3523 02:11:39,908 --> 02:11:41,976 PROJECTS AND NETWORKS, AND 3524 02:11:41,976 --> 02:11:43,178 REALLY JUST INCREASED RESEARCH 3525 02:11:43,178 --> 02:11:44,746 ON AGING IN LOW AND MIDDLE 3526 02:11:44,746 --> 02:11:46,281 INCOME COUNTRIES. 3527 02:11:46,281 --> 02:11:51,853 TYPES OF TRAINING ARE WIDE -- 3528 02:11:51,853 --> 02:11:53,354 SHORT TERM, LONG TERM, MEDIUM. 3529 02:11:53,354 --> 02:11:54,155 THEY PROPOSE PGH >> TRUSTEE 3530 02:11:54,155 --> 02:11:54,989 CROSBIE: YOU'LL INVESTIGATOR 3531 02:11:54,989 --> 02:11:56,724 MEETING TO BE HOSTED BY THE NIA 3532 02:11:56,724 --> 02:12:00,328 AND TO PRESENT THE TRAINEE 3533 02:12:00,328 --> 02:12:01,429 RESEARCH. 3534 02:12:01,429 --> 02:12:02,730 THEY'RE PLANNING EIGHT AWARDS, 3535 02:12:02,730 --> 02:12:04,265 FIVE WHICH WOULD BE IN THE 3536 02:12:04,265 --> 02:12:07,969 AD/ADRC SPACE AND THREE GENERAL. 3537 02:12:07,969 --> 02:12:09,737 THERE WILL BE SETASIDE FUNDS, 3538 02:12:09,737 --> 02:12:10,939 SPECIAL REVIEW AND A 3539 02:12:10,939 --> 02:12:13,007 PREAPPLICATION WEBINAR. 3540 02:12:13,007 --> 02:12:14,442 THERE WAS HIGH ENTHUSIASM ABOUT 3541 02:12:14,442 --> 02:12:17,712 THIS FUNDING OPPORTUNITY. 3542 02:12:17,712 --> 02:12:25,053 SO IT WILL MOVE FORWARD. 3543 02:12:25,053 --> 02:12:26,888 >> THANK YOU, JULIE. 3544 02:12:26,888 --> 02:12:28,656 THE NEXT CONCEPT IS THE DATA 3545 02:12:28,656 --> 02:12:29,991 COORDINATING CENTER FOR THE 3546 02:12:29,991 --> 02:12:32,494 AGING AND ALZHEIMER'S DISEASE 3547 02:12:32,494 --> 02:12:34,662 MOUSE BRAIN ATLAS KNOWN AS 3548 02:12:34,662 --> 02:12:36,097 ADMBA. 3549 02:12:36,097 --> 02:12:37,499 DR. HUANG IS THE PRIMARY 3550 02:12:37,499 --> 02:12:38,700 REVIEWER, DR. BAKER THE 3551 02:12:38,700 --> 02:12:39,467 SECONDARY REVIEWER. 3552 02:12:39,467 --> 02:12:40,135 DR. HUANG, IF YOU COULD PLEASE 3553 02:12:40,135 --> 02:12:41,002 PRESENT THE CONCEPT AND 3554 02:12:41,002 --> 02:12:42,337 DISCUSSION. 3555 02:12:42,337 --> 02:12:45,673 >> THIS CONCEPT PROPOSAL IS 3556 02:12:45,673 --> 02:12:47,442 SPONSORED BY DIVISION OF 3557 02:12:47,442 --> 02:12:49,077 NEUROSCIENCE, AND THE FOUNDATION 3558 02:12:49,077 --> 02:12:51,246 FOR THIS PROPOSAL IS THE 3559 02:12:51,246 --> 02:12:54,315 PROGRESSION OF ALZHEIMER'S 3560 02:12:54,315 --> 02:12:55,617 DISEASE OFTEN FOLLOWS A 3561 02:12:55,617 --> 02:12:58,686 PREDICTABLE TEMPORAL AND SPATIAL 3562 02:12:58,686 --> 02:13:00,522 PATTERN, WHERE SPECIFIC BRAIN 3563 02:13:00,522 --> 02:13:01,523 REGIONS ARE AFFECTED AT 3564 02:13:01,523 --> 02:13:04,826 DIFFERENT STAGE OF THE DISEASE. 3565 02:13:04,826 --> 02:13:07,762 HOWEVER, -- WHY THE DISEASE 3566 02:13:07,762 --> 02:13:08,663 AFFECT CERTAIN REGIONS OF THE 3567 02:13:08,663 --> 02:13:10,698 BRAIN OR WHY SPECIFIC CELL 3568 02:13:10,698 --> 02:13:13,201 SUBPOPULATION WITHIN THESE BRAIN 3569 02:13:13,201 --> 02:13:14,969 REGIONS ARE SELECTIVELY 3570 02:13:14,969 --> 02:13:15,937 VULNERABLE. 3571 02:13:15,937 --> 02:13:16,905 TO BETTER UNDERSTAND THE 3572 02:13:16,905 --> 02:13:19,307 MECHANISM AND IMPACT OF 3573 02:13:19,307 --> 02:13:23,711 SELECTIVE VULNERABILITY BETWEEN 3574 02:13:23,711 --> 02:13:26,981 REGIONS OR CELL TYPES DISPLAY 3575 02:13:26,981 --> 02:13:28,516 THIS, RECENT YEARS MULTIPLE 3576 02:13:28,516 --> 02:13:31,686 PROJECTS GENERATED A 3577 02:13:31,686 --> 02:13:34,656 COMPREHENSIVE MULTIMODAL -- 3578 02:13:34,656 --> 02:13:36,157 BRAIN CELL TYPES SPECIFICALLY ON 3579 02:13:36,157 --> 02:13:37,258 MULTI-OMICS AND ALSO THE BRAIN 3580 02:13:37,258 --> 02:13:39,327 CIRCUITS ACTIVITY CHANGE 3581 02:13:39,327 --> 02:13:43,164 ESPECIALLY ON THIS CONNECTOMICS 3582 02:13:43,164 --> 02:13:45,333 THAT ARE ALTERED DURING AGING 3583 02:13:45,333 --> 02:13:48,303 AND USING MOUSE MODELS THIS HAS 3584 02:13:48,303 --> 02:13:50,171 GENERATED MANY DATA ACROSS 3585 02:13:50,171 --> 02:13:53,441 DIFFERENT LABORATORY, HOWEVER, 3586 02:13:53,441 --> 02:13:55,944 THERE IS NO DEDICATED FUNDING TO 3587 02:13:55,944 --> 02:13:57,912 SUPPORT CENTRALIZED DATA SHARING 3588 02:13:57,912 --> 02:14:00,848 INFRASTRUCTURE AND DATA FROM 3589 02:14:00,848 --> 02:14:02,283 THIS LARGE PROJECT REMAINS 3590 02:14:02,283 --> 02:14:05,453 SOMEWHAT SILOED NOW. 3591 02:14:05,453 --> 02:14:08,089 SO TO ADDRESS THIS, THIS CONCEPT 3592 02:14:08,089 --> 02:14:10,592 PROPOSED TO CREATE A SYNERGISTIC 3593 02:14:10,592 --> 02:14:12,760 PLATFORM THAT BRINGS TOGETHER 3594 02:14:12,760 --> 02:14:20,635 MULTI-OMICS AND ALSO COULD NECKC 3595 02:14:20,635 --> 02:14:22,570 MOUSE DATA FOR A FIRST OF ITS 3596 02:14:22,570 --> 02:14:25,273 KIND RESOURCE FOR THE ASIAN AD 3597 02:14:25,273 --> 02:14:27,775 RESEARCH COMMUNITY. 3598 02:14:27,775 --> 02:14:31,879 THE PROPOSAL USING AN RFA 3599 02:14:31,879 --> 02:14:36,551 FUNDING VEHICLE U24 FUNDING 3600 02:14:36,551 --> 02:14:37,352 MAGNETS TARGETING THE RESEARCH 3601 02:14:37,352 --> 02:14:37,785 AREA. 3602 02:14:37,785 --> 02:14:38,753 AND DURING THE DISCUSSION THE 3603 02:14:38,753 --> 02:14:40,822 COUNCIL RECOGNIZED THIS IS A 3604 02:14:40,822 --> 02:14:41,923 CRITICAL NEED PLATFORM FOR THE 3605 02:14:41,923 --> 02:14:42,957 DATA COLLECTING AND 3606 02:14:42,957 --> 02:14:45,627 COORDINATING. 3607 02:14:45,627 --> 02:14:50,431 THEREFORE, WE'RE VERY -- IN 3608 02:14:50,431 --> 02:14:50,765 SUPPORTING IT. 3609 02:14:50,765 --> 02:14:51,165 THANK YOU. 3610 02:14:51,165 --> 02:14:52,166 >> THANK YOU, DR. HUANG. 3611 02:14:52,166 --> 02:14:54,469 THE NEXT CONCEPT IS 3612 02:14:54,469 --> 02:14:55,236 TRANSLATIONAL CENTER FOR 3613 02:14:55,236 --> 02:14:57,972 ACCELERATING THE USE OF DIGITAL 3614 02:14:57,972 --> 02:14:59,507 TECHNOLOGIES IN AD/ADRC 3615 02:14:59,507 --> 02:15:00,275 RESEARCH. 3616 02:15:00,275 --> 02:15:02,243 DR. LONGO IS THE PRIMARY 3617 02:15:02,243 --> 02:15:03,678 REVIEWER, DR. ASTHANA IS THE 3618 02:15:03,678 --> 02:15:05,079 SECONDARY REVIEWER, AND 3619 02:15:05,079 --> 02:15:05,747 DR. LONGO, IF YOU COULD PLEASE 3620 02:15:05,747 --> 02:15:08,283 PRESENT THE CONCEPT. 3621 02:15:08,283 --> 02:15:08,683 >> SURE. 3622 02:15:08,683 --> 02:15:09,450 THANK YOU. 3623 02:15:09,450 --> 02:15:12,086 SO AS WAS MENTIONED -- 3624 02:15:12,086 --> 02:15:13,388 >> WANT TO TURN ON YOUR 3625 02:15:13,388 --> 02:15:13,688 MICROPHONE? 3626 02:15:13,688 --> 02:15:16,491 >> THANK YOU. 3627 02:15:16,491 --> 02:15:17,659 AS WAS MENTIONED THIS PROPOSAL 3628 02:15:17,659 --> 02:15:19,527 IS FOR THE ACCELERATING THE USE 3629 02:15:19,527 --> 02:15:22,697 OF DIGITAL TECHNOLOGIES IN AD 3630 02:15:22,697 --> 02:15:27,135 AND ADRD RESEARCH IN A U54 3631 02:15:27,135 --> 02:15:27,435 MECHANISM. 3632 02:15:27,435 --> 02:15:29,937 SO THE IDEA HERE IS THAT RECENT 3633 02:15:29,937 --> 02:15:34,442 ADVANCES IN HEALTH TECHNOLOGY 3634 02:15:34,442 --> 02:15:36,177 INCLUDING WEARABLE MONITORING OR 3635 02:15:36,177 --> 02:15:39,080 ENVIRONMENT MONITORING HAVE 3636 02:15:39,080 --> 02:15:39,947 PROGRESSED TO THE POINT WHERE 3637 02:15:39,947 --> 02:15:43,985 THEY COULD HELP WITH EARLY RISK 3638 02:15:43,985 --> 02:15:45,186 ASSESSMENT, EARLY DETECTION AND 3639 02:15:45,186 --> 02:15:48,589 MONITORING OF FUNCTION IN 3640 02:15:48,589 --> 02:15:52,193 AD/ADRC RESEARCH. 3641 02:15:52,193 --> 02:15:54,395 SO THE TIMING, IT WAS FELT THAT 3642 02:15:54,395 --> 02:15:57,665 THE TIMING IS RIGHT FOR THIS. 3643 02:15:57,665 --> 02:15:59,634 THERE ARE OTHER CENTRALIZED DATA 3644 02:15:59,634 --> 02:16:00,635 CENTERS IN THE FIELD THAT HAVE 3645 02:16:00,635 --> 02:16:02,470 BEEN VERY HELPFUL TO THE FIELD, 3646 02:16:02,470 --> 02:16:04,906 INCLUDING IMAGING AND OTHER 3647 02:16:04,906 --> 02:16:07,075 BIOMARKER CENTERS, SO GIVEN THE 3648 02:16:07,075 --> 02:16:09,610 MATURATION OF DIGITAL 3649 02:16:09,610 --> 02:16:12,447 BIOMARKERS, THE TIME HAS ARRIVED 3650 02:16:12,447 --> 02:16:14,182 TO CREATE A CENTER FOR THIS KIND 3651 02:16:14,182 --> 02:16:17,151 OF DATA THAT WOULD ALLOW THE 3652 02:16:17,151 --> 02:16:18,319 SAFE STORAGE, DISTRIBUTION AND 3653 02:16:18,319 --> 02:16:19,253 SHARING AND HARMONIZATION OF 3654 02:16:19,253 --> 02:16:29,530 THIS KIND OF DATA. 3655 02:16:29,530 --> 02:16:32,367 THIS EFFORT WILL ALSO PROMOTE 3656 02:16:32,367 --> 02:16:33,468 PROGRESS IN ALZHEIMER'S 3657 02:16:33,468 --> 02:16:34,802 POPULATION SUBTYPING AND STAGING 3658 02:16:34,802 --> 02:16:36,437 AND ABILITY TO ASSESS 3659 02:16:36,437 --> 02:16:37,171 THERAPEUTIC RESPONSE. 3660 02:16:37,171 --> 02:16:38,406 DURING THE DISCUSSION, SOME OF 3661 02:16:38,406 --> 02:16:44,846 THE KEY POINTS THAT WERE MADE IS 3662 02:16:44,846 --> 02:16:46,681 THAT A VERY POTENTIAL MAJOR 3663 02:16:46,681 --> 02:16:48,116 VALUE OF THIS IS THAT REMOTE 3664 02:16:48,116 --> 02:16:49,317 COLLECTION OF THIS DATA MAY 3665 02:16:49,317 --> 02:16:51,285 ALLOWED FOR IMPROVED RECRUITMENT 3666 02:16:51,285 --> 02:16:53,688 OF DIVERSE PARTICIPANTS AND 3667 02:16:53,688 --> 02:16:55,022 REDUCE PARTICIPANT BURDEN IN 3668 02:16:55,022 --> 02:16:58,459 TRIALS, AND ALSO THAT THE CENTER 3669 02:16:58,459 --> 02:16:59,594 MAY MAKE IT POSSIBLE TO 3670 02:16:59,594 --> 02:17:00,461 INTEGRATE THIS DIGITAL TYPE OF 3671 02:17:00,461 --> 02:17:02,230 DATA WITH OTHER DATA BIOMARKER 3672 02:17:02,230 --> 02:17:06,601 AND IMAGING DATA FROM THE FIELD. 3673 02:17:06,601 --> 02:17:09,237 SO THIS PROPOSAL RECEIVED 3674 02:17:09,237 --> 02:17:12,006 SIGNIFICANT SUPPORT. 3675 02:17:12,006 --> 02:17:12,607 >> THANK YOU. 3676 02:17:12,607 --> 02:17:14,475 THE NEXT CONCEPT IS ADVANCING 3677 02:17:14,475 --> 02:17:16,978 DIVERSITY IN AGING RESEARCH 3678 02:17:16,978 --> 02:17:19,614 THROUGH UNDERGRADUATE EDUCATION 3679 02:17:19,614 --> 02:17:21,916 PROGRAMS COORDINATING CENTER. 3680 02:17:21,916 --> 02:17:23,551 DR. VAN ELDIK IS THE PRIMARY 3681 02:17:23,551 --> 02:17:24,685 REVIEWER, DR. CRUZ IS THE SECOND 3682 02:17:24,685 --> 02:17:26,954 DI REVIEWER, AND DR. VAN ELDIK, 3683 02:17:26,954 --> 02:17:28,289 IF YOU COULD PLEASE PRESENT THE 3684 02:17:28,289 --> 02:17:29,023 CONCEPT AND DISCUSSION. 3685 02:17:29,023 --> 02:17:30,224 >> YES, THANK YOU. 3686 02:17:30,224 --> 02:17:34,495 SO THIS CONCEPT PROPOSES A 3687 02:17:34,495 --> 02:17:35,830 COORDINATING CENTER FOR AN 3688 02:17:35,830 --> 02:17:37,465 EXISTING AD. 3689 02:17:37,465 --> 02:17:38,666 AR R25 PROGRAM. 3690 02:17:38,666 --> 02:17:42,136 THE R25 PROGRAM HAS BEEN VERY 3691 02:17:42,136 --> 02:17:43,471 SUCCESSFUL AT PROVIDING 3692 02:17:43,471 --> 02:17:44,138 INTENSIVE RESEARCH EXPERIENCES 3693 02:17:44,138 --> 02:17:46,541 FOR UNDERGRADUATES FROM DIVERSE 3694 02:17:46,541 --> 02:17:50,511 BACKGROUNDS WITH A GOAL OF THEM 3695 02:17:50,511 --> 02:17:51,379 TRANSITIONING INTOED A 3696 02:17:51,379 --> 02:17:52,346 VANED DEGREE PROGRAMS OR 3697 02:17:52,346 --> 02:17:53,681 RESEARCH CAREERS IN 3698 02:17:53,681 --> 02:17:54,449 AGING-RELATED DISCIPLINES. 3699 02:17:54,449 --> 02:17:58,920 THERE ARE CURRENTLY 31 ADAR R25 3700 02:17:58,920 --> 02:18:00,655 PROGRAMS AND FIVE NEW ONES IN 3701 02:18:00,655 --> 02:18:03,191 FISCAL YEAR 24. 3702 02:18:03,191 --> 02:18:04,859 AND I REALLY LIKED THE METRICS 3703 02:18:04,859 --> 02:18:05,827 THAT WERE PRESENTED IN THIS 3704 02:18:05,827 --> 02:18:07,695 CONCEPT. 3705 02:18:07,695 --> 02:18:09,764 THAT DOCUMENTED THE HIGH SUCCESS 3706 02:18:09,764 --> 02:18:11,299 OF THE R25 PROGRAM. 3707 02:18:11,299 --> 02:18:13,868 SO FOR EXAMPLE, THE R25 PROGRAMS 3708 02:18:13,868 --> 02:18:17,872 HAVE SERVED ALMOST 700 3709 02:18:17,872 --> 02:18:19,073 UNDERGRADUATES, 71% FROM 3710 02:18:19,073 --> 02:18:19,941 UNDERREPRESENTED RACIAL AND 3711 02:18:19,941 --> 02:18:23,344 ETHNIC GROUPS, 50% WOMEN, 33% 3712 02:18:23,344 --> 02:18:25,513 FROM DISADVANTAGED BACKGROUNDS 3713 02:18:25,513 --> 02:18:26,814 AND 6% INDIVIDUALS WITH 3714 02:18:26,814 --> 02:18:31,118 DISABILITIES. 3715 02:18:31,118 --> 02:18:35,022 OF THE GRADUATES OF ALMOST 400, 3716 02:18:35,022 --> 02:18:36,123 54% WERE ACCEPTED TO GRADUATE 3717 02:18:36,123 --> 02:18:39,527 SCHOOL AND 83% OF THOSE WERE IN 3718 02:18:39,527 --> 02:18:40,161 AGING-RELATED GRADUATE PROGRAMS. 3719 02:18:40,161 --> 02:18:42,697 SO THE R25 EFFORT HAS BEEN VERY 3720 02:18:42,697 --> 02:18:43,998 SUCCESSFUL, BUT BECAUSE IT'S 3721 02:18:43,998 --> 02:18:45,867 BEEN EXPANDING AND THERE ARE 3722 02:18:45,867 --> 02:18:48,035 SOME CHALLENGES THAT REMAIN WITH 3723 02:18:48,035 --> 02:18:49,704 THE PROGRAM THAT HAVE TO BE 3724 02:18:49,704 --> 02:18:51,105 ADDRESSED, AND THAT'S WHAT THE 3725 02:18:51,105 --> 02:18:52,540 COORDINATING CENTER WOULD DO. 3726 02:18:52,540 --> 02:18:55,142 SO THE COORDINATING CENTER IS 3727 02:18:55,142 --> 02:18:58,679 ENVISIONED TO PROVIDE 3728 02:18:58,679 --> 02:18:59,413 COORDINATION COMMUNICATION AMONG 3729 02:18:59,413 --> 02:19:02,817 ALL THE R25 ADAR SITES. 3730 02:19:02,817 --> 02:19:04,018 THERE'S A NEED FOR SUPPORT FOR 3731 02:19:04,018 --> 02:19:06,087 SOME OF THE SITES TO DEVELOP NEW 3732 02:19:06,087 --> 02:19:07,522 PARTNERSHIPS AND BECOME 3733 02:19:07,522 --> 02:19:07,855 SUSTAINABLE. 3734 02:19:07,855 --> 02:19:10,892 A NEED FOR COMMON METRICS, 3735 02:19:10,892 --> 02:19:11,926 UNIFORM EVALUATION STRATEGIES 3736 02:19:11,926 --> 02:19:14,328 AND HARMONIZED REPORTING. 3737 02:19:14,328 --> 02:19:14,629 FOR 3738 02:19:14,629 --> 02:19:15,730 BETTER TRACKING OF THE 3739 02:19:15,730 --> 02:19:17,265 PARTICIPANTS AND OUTCOMES. 3740 02:19:17,265 --> 02:19:22,403 AND SO THIS IS ENVISIONED TO BE 3741 02:19:22,403 --> 02:19:26,474 A COMPANION TO A CONCURRENTLY 3742 02:19:26,474 --> 02:19:29,510 REISSUED ADAR R258 NOFO WHICH 3743 02:19:29,510 --> 02:19:32,146 WOULD REQUIRE AND INTERSENT 3744 02:19:32,146 --> 02:19:33,347 ADVISE THE R25 PROGRAMS TO WORK 3745 02:19:33,347 --> 02:19:34,815 WITH THE COORDINATING CENTER. 3746 02:19:34,815 --> 02:19:36,183 THE COORDINATING CENTER WOULD BE 3747 02:19:36,183 --> 02:19:38,252 A U24 AND THERE WOULD BE A 3748 02:19:38,252 --> 02:19:40,121 SINGLE DUE DATE IN 2025 FOR BOTH 3749 02:19:40,121 --> 02:19:42,423 THE ADAR R25 APPLICATIONS AND 3750 02:19:42,423 --> 02:19:48,029 THE COORDINATING CENTER. 3751 02:19:48,029 --> 02:19:48,996 THIS CONCEPT WAS JUDGED TO BE 3752 02:19:48,996 --> 02:19:50,197 VERY IMPORTANT AND WOULD ALLOW 3753 02:19:50,197 --> 02:19:53,267 FURTHER STRENGTHENING OF AN 3754 02:19:53,267 --> 02:19:54,936 ALREADY VERY SUCCESSFUL R25 3755 02:19:54,936 --> 02:19:56,037 RESEARCH EDUCATION PROGRAM, AND 3756 02:19:56,037 --> 02:20:00,608 TO EXPAND AND DIVERSIFY, IT'S 3757 02:20:00,608 --> 02:20:02,243 THE SKILLED AGING RESEARCH 3758 02:20:02,243 --> 02:20:04,512 WORKFORCE OF THE FUTURE, IT WAS 3759 02:20:04,512 --> 02:20:07,048 DISCUSSED THAT IT'S CRITICAL TO 3760 02:20:07,048 --> 02:20:08,583 REACH INDIVIDUALS EARLY IN THEIR 3761 02:20:08,583 --> 02:20:13,454 CAREERS AS THIS R25 PROGRAM DOED 3762 02:20:13,454 --> 02:20:14,789 SHOW THESE STUDENTS HOW ECK 3763 02:20:14,789 --> 02:20:16,657 SITING AND HOW FEASIBLE A FUTURE 3764 02:20:16,657 --> 02:20:18,593 CAREER IN AGING-RELATED RESEARCH 3765 02:20:18,593 --> 02:20:19,927 CAN BE. 3766 02:20:19,927 --> 02:20:22,897 SO THE U24 COORDINATING CENTER 3767 02:20:22,897 --> 02:20:25,266 WOULD ENABLE THIS GOAL BEYOND 3768 02:20:25,266 --> 02:20:26,834 EACH INDIVIDUAL R25 SITE, AND 3769 02:20:26,834 --> 02:20:27,902 THE COMMITTEE WAS VERY 3770 02:20:27,902 --> 02:20:31,005 SUPPORTIVE OF THE CONCEPT. 3771 02:20:31,005 --> 02:20:32,974 >> YO THANK YOU, LINDA. 3772 02:20:32,974 --> 02:20:34,842 THE NEXT CONCEPT IS TRANSITION 3773 02:20:34,842 --> 02:20:36,811 TO AGING RESEARCH FOR 3774 02:20:36,811 --> 02:20:38,346 PREDOCTORAL FELLOWS. 3775 02:20:38,346 --> 02:20:39,547 DR. ASTHANA IS THE PRIMARY 3776 02:20:39,547 --> 02:20:41,749 REVIEWER, AND DR. LONGO WAS THE 3777 02:20:41,749 --> 02:20:43,384 SECONDARY REVIEWER. 3778 02:20:43,384 --> 02:20:44,585 AND SANJAY, IF YOU COULD PLEASE 3779 02:20:44,585 --> 02:20:45,386 PRESENT THE CONCEPT. 3780 02:20:45,386 --> 02:20:47,722 >> THANK YOU. 3781 02:20:47,722 --> 02:20:50,091 SO THIS CONCEPT RECEIVED 3782 02:20:50,091 --> 02:20:51,726 ENTHUSIASTIC SUPPORT FROM THE 3783 02:20:51,726 --> 02:20:52,793 COUNCIL, REQUESTS NEW SUPPORT 3784 02:20:52,793 --> 02:20:56,731 FOR AN F99/K00 AWARD THAT 3785 02:20:56,731 --> 02:20:59,734 STARTED AS A PA PILOT PROGRAM IN 3786 02:20:59,734 --> 02:21:01,168 2020 TO SUPPORT GRADUATE 3787 02:21:01,168 --> 02:21:02,103 STUDENTS DURING THEIR DOCTORAL 3788 02:21:02,103 --> 02:21:03,437 STUDIES, AND THEN WHEN THEY 3789 02:21:03,437 --> 02:21:07,241 BECOME POSTDOCTORAL FELLOWS, TO 3790 02:21:07,241 --> 02:21:09,343 PURSUE THEIR TRAINING IN AGING 3791 02:21:09,343 --> 02:21:09,977 RESEARCH. 3792 02:21:09,977 --> 02:21:11,312 THE PILOT PROGRAM HAS BEEN 3793 02:21:11,312 --> 02:21:12,513 EXTREMELY SUCCESSFUL WITH 3794 02:21:12,513 --> 02:21:13,714 INCREASING NUMBER OF 3795 02:21:13,714 --> 02:21:14,782 APPLICATIONS OVER THE YEARS. 3796 02:21:14,782 --> 02:21:19,120 FOR EXAMPLE, BETWEEN FISCAL 2020 3797 02:21:19,120 --> 02:21:22,923 AND 2023, NIA HAS RECEIVED 126 3798 02:21:22,923 --> 02:21:26,861 APPLICATIONS, OF WHICH 37 WERE 3799 02:21:26,861 --> 02:21:28,496 FUNDED, AND AMONG THESE 3800 02:21:28,496 --> 02:21:29,263 AWARDEES, 26 HAVE ALREADY 3801 02:21:29,263 --> 02:21:30,464 COMPLETED THEIR DOCTORAL 3802 02:21:30,464 --> 02:21:32,099 TRAINING AND ALL -- SORRY -- 3803 02:21:32,099 --> 02:21:34,568 PREDOCTORAL TRAINING AND ALL BUT 3804 02:21:34,568 --> 02:21:36,270 THREE HAVE BECOME POSTDOCS IN 3805 02:21:36,270 --> 02:21:37,104 AGING RESEARCH. 3806 02:21:37,104 --> 02:21:40,274 AND THE PRODUCTIVITY OF THESE 3807 02:21:40,274 --> 02:21:41,409 AWARDEES HAS BEEN IMPRESSIVE. 3808 02:21:41,409 --> 02:21:44,979 ON AVERAGE THEY'VE PUB LIRKED PD 3809 02:21:44,979 --> 02:21:45,880 ABOUT THREE PAPERS IN 3810 02:21:45,880 --> 02:21:46,414 GERONTOLOGY FIELD. 3811 02:21:46,414 --> 02:21:48,382 SOME OF THE LIMITATIONS WITH THE 3812 02:21:48,382 --> 02:21:50,117 PRESENT AWARD THAT MAY 3813 02:21:50,117 --> 02:21:52,753 SIGNIFICANTLY REDUCE THE 3814 02:21:52,753 --> 02:21:55,089 INTEREST RELATE TO VERY LOW 3815 02:21:55,089 --> 02:21:56,924 STIPENDS FOR PREDOCTORAL FELLOW, 3816 02:21:56,924 --> 02:21:59,226 THE POSTDOCS AND ALSO A SINGLE 3817 02:21:59,226 --> 02:22:01,328 RECEIPT DATE FOR THE APPLICATION 3818 02:22:01,328 --> 02:22:03,497 EACH YEAR THAT PREVENTS 3819 02:22:03,497 --> 02:22:05,566 APPLICANTS FROM SUBMITTING A 3820 02:22:05,566 --> 02:22:07,768 RESUBMISSION BECAUSE THERE'S 3821 02:22:07,768 --> 02:22:11,172 ONLY ONE RECEIPT DATE EACH YEAR. 3822 02:22:11,172 --> 02:22:13,374 FURTHERMORE, THE SETASIDE FUNDS 3823 02:22:13,374 --> 02:22:16,410 CAN ONLY SUPPORT LIMITED 3824 02:22:16,410 --> 02:22:18,312 MERITORIOUS APPLICATIONS AND 3825 02:22:18,312 --> 02:22:19,513 THAT IS A MAJOR LIMITATION. 3826 02:22:19,513 --> 02:22:24,218 SO THE RENEWAL REQUESTS SPECIFIC 3827 02:22:24,218 --> 02:22:26,487 INCREASES IN THE STIPENDS FOR 3828 02:22:26,487 --> 02:22:29,023 PRE-DOCS, FOR POSTDOCS, ALSO 3829 02:22:29,023 --> 02:22:30,891 INCREASING SUPPORT FOR CAREER 3830 02:22:30,891 --> 02:22:33,427 DEVELOPMENT FOR THE TRAINEE TO 3831 02:22:33,427 --> 02:22:35,096 INCREASE THE RECEIPT DATES EACH 3832 02:22:35,096 --> 02:22:37,364 YEAR FROM ONE TO TWO, AND ALSO 3833 02:22:37,364 --> 02:22:41,168 TO HAVE LARGER SETASIDES SO THEY 3834 02:22:41,168 --> 02:22:43,137 CAN FUND SEVEN GENERAL AND SEVEN 3835 02:22:43,137 --> 02:22:44,438 AD/ADRC APPLICATIONS. 3836 02:22:44,438 --> 02:22:47,308 SO THIS CONCEPT WAS THOUGHT TO 3837 02:22:47,308 --> 02:22:50,211 BE ESSENTIAL TO CONTINUE 3838 02:22:50,211 --> 02:22:51,479 TRAINING OF PRE-DOCS AND 3839 02:22:51,479 --> 02:22:52,780 POSTDOCS IN AGING RESEARCH, AND 3840 02:22:52,780 --> 02:22:55,082 THE COUNCIL PROVIDED VERY STRONG 3841 02:22:55,082 --> 02:22:55,549 SUPPORT. 3842 02:22:55,549 --> 02:22:57,084 >> THANK YOU, SANJAY. 3843 02:22:57,084 --> 02:23:00,154 AND THE LAST CONCEPT, NEW 3844 02:23:00,154 --> 02:23:02,123 GENERAL AGING T32 PROGRAM. 3845 02:23:02,123 --> 02:23:03,991 I WAS THE PRIMARY REVIEWER, AND 3846 02:23:03,991 --> 02:23:05,292 DR. VAN ELDIK WAS THE SECONDARY 3847 02:23:05,292 --> 02:23:07,828 REVIEWER. 3848 02:23:07,828 --> 02:23:10,698 SO NIA'S T32 PROGRAM IS A 3849 02:23:10,698 --> 02:23:12,566 CORNERSTONE OF THE INSTITUTE'S 3850 02:23:12,566 --> 02:23:13,768 TRAINING AND CAREER DEVELOPMENT 3851 02:23:13,768 --> 02:23:14,535 PROGRAMMING. 3852 02:23:14,535 --> 02:23:17,071 IT PROVIDES SUPPORT TO 3853 02:23:17,071 --> 02:23:18,272 INSTITUTIONS TO SELECT 3854 02:23:18,272 --> 02:23:22,309 PREDOCTORAL AND/OR POSTDOCTORAL 3855 02:23:22,309 --> 02:23:24,311 SCHOLARS AND DEVELOP A PROGRAM 3856 02:23:24,311 --> 02:23:25,279 OF COURSE WORK, MENTORED 3857 02:23:25,279 --> 02:23:26,647 RESEARCH, EXPERIENCES, AND 3858 02:23:26,647 --> 02:23:27,915 TECHNICAL AND PROFESSIONAL 3859 02:23:27,915 --> 02:23:29,550 SKILLS DEVELOPMENT RELEVANT TO 3860 02:23:29,550 --> 02:23:31,552 AGING RESEARCH. 3861 02:23:31,552 --> 02:23:33,821 HOWEVER, THE NEW APPLICATIONS 3862 02:23:33,821 --> 02:23:35,689 APPEAR TO DO WORSE WITH A MEDIAN 3863 02:23:35,689 --> 02:23:38,459 SCORE OF ABOUT 34 THAN RENEWAL 3864 02:23:38,459 --> 02:23:39,527 APPLICATIONS WITH A MEDIAN SCORE 3865 02:23:39,527 --> 02:23:41,829 OF ABOUT 19. 3866 02:23:41,829 --> 02:23:43,597 RENEWAL APPLICATIONS ALSO 3867 02:23:43,597 --> 02:23:45,566 REQUEST MORE TRAINING SLOTS, 3868 02:23:45,566 --> 02:23:47,334 LEADING TO HIGHER COSTS FOR THE 3869 02:23:47,334 --> 02:23:48,736 OVERALL GRANT. 3870 02:23:48,736 --> 02:23:50,938 THIS RESULTS IN THE RENEWAL 3871 02:23:50,938 --> 02:23:52,573 APPLICATIONS CROWDING OUT THE 3872 02:23:52,573 --> 02:23:54,675 NEW APPLICATIONS IN COST. 3873 02:23:54,675 --> 02:23:56,644 THIS IS ALSO SHOWN BY THE 3874 02:23:56,644 --> 02:23:58,279 SUCCESS RATE FOR RENEWAL 3875 02:23:58,279 --> 02:24:01,148 APPLICATIONS OF 62% SUCCESS RATE 3876 02:24:01,148 --> 02:24:03,317 COMPARED TO 13% SUCCESS RATE FOR 3877 02:24:03,317 --> 02:24:04,785 NEW APPLICATIONS. 3878 02:24:04,785 --> 02:24:08,823 IN FACT, THERE WAS ONLY ONE NEW 3879 02:24:08,823 --> 02:24:10,224 T32 APPLICATION FUNDED OVER THE 3880 02:24:10,224 --> 02:24:13,194 LAST SEVERAL YEARS. 3881 02:24:13,194 --> 02:24:16,163 SO THIS CONCEPT WOULD PROVIDE 3882 02:24:16,163 --> 02:24:19,767 SETASIDE FUNDS SPECIFICALLY TO 3883 02:24:19,767 --> 02:24:21,735 SUPPORT THREE GENERAL AGING 3884 02:24:21,735 --> 02:24:23,137 T32 APPLICATIONS PER YEAR, AND 3885 02:24:23,137 --> 02:24:24,939 THEY WOULD NOT BE COMPETING 3886 02:24:24,939 --> 02:24:27,441 AGAINST THE PREVIOUS OLD 3887 02:24:27,441 --> 02:24:28,209 T32 APPLICATIONS. 3888 02:24:28,209 --> 02:24:30,344 THIS WOULD BE ACTIVE FOR THREE 3889 02:24:30,344 --> 02:24:31,879 YEARS WITH ONE RECEIPT DATE PER 3890 02:24:31,879 --> 02:24:32,513 YEAR. 3891 02:24:32,513 --> 02:24:34,615 IT WOULD ALSO ENCOURAGE 3892 02:24:34,615 --> 02:24:36,450 INSTITUTIONS THAT HAVE NOT 3893 02:24:36,450 --> 02:24:41,055 PREVIOUSLY HELD AN NIA-FUNDED 3894 02:24:41,055 --> 02:24:42,590 T32 TO APPLY, AND THIS WOULD 3895 02:24:42,590 --> 02:24:46,794 HELP DIVERSITY OF THE NIA 3896 02:24:46,794 --> 02:24:47,328 T32 PROGRAM. 3897 02:24:47,328 --> 02:24:49,296 THERE WAS SIGNIFICANT ENTHUSIASM 3898 02:24:49,296 --> 02:24:52,800 FOR THE CONCEPT, AND ENTHUSIASM 3899 02:24:52,800 --> 02:24:57,204 TO MOVE THIS FORWARD. 3900 02:24:57,204 --> 02:24:59,106 SO AT THIS POINT, I'D LIKE TO 3901 02:24:59,106 --> 02:25:02,776 ASK FOR AN EN BLOC APPROVAL VOTE 3902 02:25:02,776 --> 02:25:05,512 FOR THE CONCEPTS, FOR ALL THE 3903 02:25:05,512 --> 02:25:07,715 CONCEPTS THAT WE DISCUSSED. 3904 02:25:07,715 --> 02:25:11,118 SO ALL THOSE THAT APPROVE THE 3905 02:25:11,118 --> 02:25:12,219 CONCEPTS, PLEASE RAISE YOUR HAND 3906 02:25:12,219 --> 02:25:15,389 OR SAY YES. 3907 02:25:15,389 --> 02:25:16,924 ANY OPPOSED TO APPROVING THE 3908 02:25:16,924 --> 02:25:18,993 CONCEPTS? 3909 02:25:18,993 --> 02:25:21,629 SO ALL THE CONCEPTS HAVE 3910 02:25:21,629 --> 02:25:22,496 ENTHUSIASTICALLY BEEN APPROVED 3911 02:25:22,496 --> 02:25:23,163 TO MOVE FORWARD. 3912 02:25:23,163 --> 02:25:24,031 THANK YOU. 3913 02:25:24,031 --> 02:25:25,032 AND NOW I'M GOING TO TURN IT 3914 02:25:25,032 --> 02:25:29,870 BACK TO KEN. 3915 02:25:29,870 --> 02:25:30,437 >> PERFECT. 3916 02:25:30,437 --> 02:25:31,272 THANK YOU, SUSAN. 3917 02:25:31,272 --> 02:25:33,674 I THINK AT THIS POINT NOW, NEXT 3918 02:25:33,674 --> 02:25:35,242 UP WE DO HAVE TWO SPEAKERS BUT 3919 02:25:35,242 --> 02:25:37,044 WE'RE GOING TO TAKE A BREAK 3920 02:25:37,044 --> 02:25:39,480 FIRST. 3921 02:25:39,480 --> 02:25:42,216 SO IT IS NOW 11:25. 3922 02:25:42,216 --> 02:25:46,754 I'D LIKE TO TAKE AT LEAST A 3923 02:25:46,754 --> 02:25:49,056 20-MINUTE BREAK, SO WE WILL BE 3924 02:25:49,056 --> 02:25:52,026 ABLE TO COME BACK HERE ABOUT -- 3925 02:25:52,026 --> 02:25:54,161 LET'S JUST SAY ABOUT 10 OF 3926 02:25:54,161 --> 02:25:54,728 12:00. 3927 02:25:54,728 --> 02:25:58,032 WE HAVE, AGAIN, TWO SPEAKERS, 3928 02:25:58,032 --> 02:26:01,101 OUR NIH SPEAKER, DR. JANINE 3929 02:26:01,101 --> 02:26:02,202 CLAYTON FROM THE OFFICE OF 3930 02:26:02,202 --> 02:26:05,172 WOMEN'S HEALTH, AND THEN OUR 3931 02:26:05,172 --> 02:26:08,542 SCIENTIFIC SPEAKER, DR. HOLLY 3932 02:26:08,542 --> 02:26:09,043 INGRAHAM, UNIVERSITY OF 3933 02:26:09,043 --> 02:26:11,979 CALIFORNIA. 3934 02:26:11,979 --> 02:26:12,446 -SAN FRANCISCO. 3935 02:26:12,446 --> 02:26:13,480 SO WE'LL LOOK FORWARD TO HAVING 3936 02:26:13,480 --> 02:26:15,883 THOSE SPEAKERS, BUT WE'LL TAKE A 3937 02:26:15,883 --> 02:26:19,434 BREAK NOW. 3938 02:26:19,434 --> 02:26:20,535 WELL, AS I THINK YOU'RE GOING TO 3939 02:26:20,535 --> 02:26:22,904 SEE, WE HAVE A WONDERFULLY 3940 02:26:22,904 --> 02:26:24,872 ORCHESTRATED PAIR OF SPEAKERS 3941 02:26:24,872 --> 02:26:25,506 AHEAD OF US. 3942 02:26:25,506 --> 02:26:26,607 IT'S MY PRIVILEGE TO INTRODUCE 3943 02:26:26,607 --> 02:26:28,443 THE FIRST OF THOSE, DR. JANINE 3944 02:26:28,443 --> 02:26:29,978 CLAYTON, WHO IS THE ASSOCIATE 3945 02:26:29,978 --> 02:26:34,048 DIRECTOR AT NIH FOR RESEARCH ON 3946 02:26:34,048 --> 02:26:37,185 WOMEN'S HEALTH AND THE DIRECTOR 3947 02:26:37,185 --> 02:26:37,518 OF THE OFFICE. 3948 02:26:37,518 --> 02:26:40,722 SHE WAS TRAINED IN MEDICINE AND 3949 02:26:40,722 --> 02:26:43,057 OPT MOL GEE, SPENT HER PREVIOUS 3950 02:26:43,057 --> 02:26:45,626 POSITION AT NEI AS THE DEPUTY 3951 02:26:45,626 --> 02:26:46,828 CLINICAL DIRECTOR, THEN SINCE 3952 02:26:46,828 --> 02:26:49,097 2012, SO ABOUT 12 YEARS NOW, HAS 3953 02:26:49,097 --> 02:26:51,566 BEEN IN THE CURRENT POSITION. 3954 02:26:51,566 --> 02:26:56,170 NIA OVER ALL THOSE 12 YEARS HAS 3955 02:26:56,170 --> 02:26:58,439 HAD THE OPPORTUNITY TO WORK VERY 3956 02:26:58,439 --> 02:27:00,475 CLOSELY ON AREAS OF SEX AS A 3957 02:27:00,475 --> 02:27:02,543 BIOLOGICAL VARIABLE AND ALL THE 3958 02:27:02,543 --> 02:27:04,512 WAYS IN WHICH SEX GENDER OVER 3959 02:27:04,512 --> 02:27:05,813 THE LIFE TERM HAS BEEN A PRIMARY 3960 02:27:05,813 --> 02:27:06,547 FOCUS FOR ALL OF US. 3961 02:27:06,547 --> 02:27:08,049 SO IT'S A GREAT PLEASURE TO HAVE 3962 02:27:08,049 --> 02:27:09,584 HER HERE TO SPEAK TO US ABOUT 3963 02:27:09,584 --> 02:27:11,185 HER WORK AND OUR WORK TOGETHER. 3964 02:27:11,185 --> 02:27:17,759 JANINE, WELCOME. 3965 02:27:17,759 --> 02:27:19,160 >> THANK YOU, RICHARD. 3966 02:27:19,160 --> 02:27:20,228 EXCITING TO BE HERE. 3967 02:27:20,228 --> 02:27:21,529 I SEE SOME FRIENDS IN THE 3968 02:27:21,529 --> 02:27:22,730 AUDIENCE AND I'M THRILLED TO 3969 02:27:22,730 --> 02:27:24,365 TELL YOU A LITTLE BIT ABOUT WHAT 3970 02:27:24,365 --> 02:27:26,734 WE'RE DOING AT THE OFFICE OF 3971 02:27:26,734 --> 02:27:30,104 RESEARCH ON WOMEN'S HEALTH, 3972 02:27:30,104 --> 02:27:30,471 ORWH. 3973 02:27:30,471 --> 02:27:32,407 WE'RE REALLY GOING TO FOCUS ON 3974 02:27:32,407 --> 02:27:33,674 OUR EFFORTS INTERSECTING WITH 3975 02:27:33,674 --> 02:27:35,777 YOUR EFFORTS AND NIH-WIDE 3976 02:27:35,777 --> 02:27:37,412 ADDRESSING THE FACT THAT WE MUST 3977 02:27:37,412 --> 02:27:40,448 CONSIDER WOMEN'S HEALTH ASTRA 3978 02:27:40,448 --> 02:27:47,822 ASTRAJECTORIES ACROSS THE LIFE 3979 02:27:47,822 --> 02:27:48,623 FORCE AND PAY ATTENTION TO 3980 02:27:48,623 --> 02:27:49,824 SPECIFIC INFLECTION POINTS. 3981 02:27:49,824 --> 02:27:52,026 I OFTEN BEGIN WITH THIS THAT 3982 02:27:52,026 --> 02:27:54,962 INCLUSION IS IN OUR DNA BECAUSE 3983 02:27:54,962 --> 02:27:58,633 ORWH UNLIKE NIA IS MUCH YOUNGER. 3984 02:27:58,633 --> 02:28:00,501 WE WERE FOUNDED IN 2090 3985 02:28:00,501 --> 02:28:01,903 BASICALLY TO MAKE SURE THAT 3986 02:28:01,903 --> 02:28:04,172 WOMEN WERE INCLUDED IN NIH 3987 02:28:04,172 --> 02:28:05,273 SUPPORTED CLINICAL TRIALS. 3988 02:28:05,273 --> 02:28:10,178 SO TH THE NIH93 REVITALIZATION T 3989 02:28:10,178 --> 02:28:11,946 IS THE LEGISLATIVE LANGUAGE IN 3990 02:28:11,946 --> 02:28:13,314 THE UNITED STATES THAT REQUIRES 3991 02:28:13,314 --> 02:28:14,949 WOMEN BE INCLUDED IN NIH 3992 02:28:14,949 --> 02:28:16,584 SUPPORTED STUDIES AND AGAIN SO 3993 02:28:16,584 --> 02:28:17,518 THAT THE FINDINGS FROM THOSE 3994 02:28:17,518 --> 02:28:19,153 STUDIES MIGHT BE MORE RIGOROUS 3995 02:28:19,153 --> 02:28:20,455 AND CERTAINLY GENERALIZABLE TO 3996 02:28:20,455 --> 02:28:23,024 THE POPULATIONS AFFECTED BY THE 3997 02:28:23,024 --> 02:28:24,225 DISEASES AND WITH THE NATIONAL 3998 02:28:24,225 --> 02:28:25,126 INSTITUTE ON AGING IT WAS OUR 3999 02:28:25,126 --> 02:28:27,995 PLEASURE TO COLLABORATE IN 4000 02:28:27,995 --> 02:28:29,130 EXPANDING THE NIH INCLUSION 4001 02:28:29,130 --> 02:28:30,098 POLICY SEVERAL YEARS AGO 4002 02:28:30,098 --> 02:28:31,632 CONSISTENT WITH THE 21ST CENTURY 4003 02:28:31,632 --> 02:28:32,700 CURES ACT TO INCLUDE THAT TO 4004 02:28:32,700 --> 02:28:33,434 INDIVIDUALS OF ALL AGES. 4005 02:28:33,434 --> 02:28:39,006 SO NOW WE ALSO HA AM CAL PHASE 4006 02:28:39,006 --> 02:28:39,974 3 CLINICAL TRIALS NEEDING TO 4007 02:28:39,974 --> 02:28:41,609 REPORT THEIR RESULTS, 4008 02:28:41,609 --> 02:28:44,011 DISAGGREGATED BY SEX OR GENDER, 4009 02:28:44,011 --> 02:28:45,847 RACE AND ETHNICITY INTO CLINICAL 4010 02:28:45,847 --> 02:28:47,348 TRIALS. 4011 02:28:47,348 --> 02:28:50,751 SO THEY'RE NOW REQUIRED IN 4012 02:28:50,751 --> 02:28:50,985 CT.GOV. 4013 02:28:50,985 --> 02:28:52,453 OF COURSE NIH HAS SUPPORTED 4014 02:28:52,453 --> 02:28:53,988 RESEARCH RELEVANT TO THE HEALTH 4015 02:28:53,988 --> 02:28:56,624 OF WOMEN SINCE ITS OUTSET, AND 4016 02:28:56,624 --> 02:28:59,093 FROM THE WHI, THE WOMEN'S HEALTH 4017 02:28:59,093 --> 02:29:00,161 INITIATIVE, THEN INITIATED BY 4018 02:29:00,161 --> 02:29:04,432 THE FIRST WOMAN DIRECTOR OF NIH, 4019 02:29:04,432 --> 02:29:07,068 NOW WE HAVE A SECOND WOMAN 4020 02:29:07,068 --> 02:29:09,337 DIRECTOR, DR. MONICA 4021 02:29:09,337 --> 02:29:10,972 BERTAGNOLLI, THE WHI WAS A 4022 02:29:10,972 --> 02:29:12,073 LANDMARK INITIATIVE. 4023 02:29:12,073 --> 02:29:14,475 BUT IN ADDITION TO THAT, SWAN, 4024 02:29:14,475 --> 02:29:16,077 STUDY OF WOMEN'S HEALTH ACROSS 4025 02:29:16,077 --> 02:29:21,883 THE NAUSEOUS, NATION, BEGINNING, 4026 02:29:21,883 --> 02:29:23,284 SO IT'S THE 30TH ANNIVERSARY OF 4027 02:29:23,284 --> 02:29:23,818 SWAN. 4028 02:29:23,818 --> 02:29:27,922 BASIC SCIENCE WENT TOWARD 4029 02:29:27,922 --> 02:29:29,991 DEVELOPING THE HPV VACCINE, 4030 02:29:29,991 --> 02:29:33,828 BASIC SCIENCE EFFORTS IDENTIFIED 4031 02:29:33,828 --> 02:29:36,397 JAK AS A POTENTIAL TARGET AND 4032 02:29:36,397 --> 02:29:38,266 LED TO JAK INHIBITORS, AGAIN 4033 02:29:38,266 --> 02:29:39,934 STATE OF THE ART TREATMENT FOR 4034 02:29:39,934 --> 02:29:41,269 AUTOIMMUNE DISEASES TODAY THAT 4035 02:29:41,269 --> 02:29:45,006 AFFECT MORE WOMEN THAN MEN, GTEX 4036 02:29:45,006 --> 02:29:45,439 AND OTHERS. 4037 02:29:45,439 --> 02:29:47,074 IT BEEN A ROBUST INVESTMENT FOR 4038 02:29:47,074 --> 02:29:48,476 MANY YEARS ACROSS THE ENTIRE 4039 02:29:48,476 --> 02:29:50,411 RESEARCH CONTINUUM FROM THE MOST 4040 02:29:50,411 --> 02:29:53,481 BASIC THROUGH TRANSLATION IN 4041 02:29:53,481 --> 02:29:54,682 CLINICAL AND APPLIED. 4042 02:29:54,682 --> 02:29:56,083 THE STUDY OF WOMEN'S HEALTH 4043 02:29:56,083 --> 02:29:59,353 ACROSS THE NATION IS AN 4044 02:29:59,353 --> 02:30:00,555 INCREDIBLE RESOURCE, AND I THINK 4045 02:30:00,555 --> 02:30:01,923 A GIFT TO THE WOMEN'S HEALTH 4046 02:30:01,923 --> 02:30:03,024 COMMUNITY. 4047 02:30:03,024 --> 02:30:05,660 STARTED IN 1994 AS I MENTIONED, 4048 02:30:05,660 --> 02:30:07,228 HIGHLY DIVERSE BY DESIGN FROM 4049 02:30:07,228 --> 02:30:10,531 THE OUTSET, LOOKING AT WOMEN 4050 02:30:10,531 --> 02:30:11,632 BEFORE THEY'RE GOING THROUGH 4051 02:30:11,632 --> 02:30:12,700 MENOPAUSE, SO YOU COULD CAPTURE 4052 02:30:12,700 --> 02:30:14,435 THAT FULL MENOPAUSE TRANSITION, 4053 02:30:14,435 --> 02:30:18,472 AND I DON'T KNOW IF DR. DOVE IS 4054 02:30:18,472 --> 02:30:19,774 HERE OR ONLINE BUT SHE'S BEEN 4055 02:30:19,774 --> 02:30:21,209 GREAT TO WORK ON THIS AND OTHER 4056 02:30:21,209 --> 02:30:21,475 EFFORTS. 4057 02:30:21,475 --> 02:30:23,211 YOU ALL PROBABLY KNOW THIS STUDY 4058 02:30:23,211 --> 02:30:24,312 VERY, VERY WELL. 4059 02:30:24,312 --> 02:30:26,681 IT INCLUDES LOOKING AT THE 4060 02:30:26,681 --> 02:30:28,049 MENOPAUSAL TRANSITION AND 4061 02:30:28,049 --> 02:30:29,884 OUTCOMES, AND INCLUDES THE 4062 02:30:29,884 --> 02:30:31,752 POSSIBILITY AND HAS NOW LED TO 4063 02:30:31,752 --> 02:30:42,863 THE EV EVENT E EVENTUALITY OF IG 4064 02:30:44,465 --> 02:30:44,966 DIFFERENCES ACROSS DIFFERENT 4065 02:30:44,966 --> 02:30:46,467 RACES AND ETHNICITIES. 4066 02:30:46,467 --> 02:30:47,768 I HAVE THE PRIVILEGE OF WORKING 4067 02:30:47,768 --> 02:30:49,203 WITH EVERY SINGLE INSTITUTE AND 4068 02:30:49,203 --> 02:30:50,638 CENTER HERE AT NIH AND EACH OF 4069 02:30:50,638 --> 02:30:53,341 THEM HAS A ROBUST WOMEN'S HEALTH 4070 02:30:53,341 --> 02:30:55,076 RESEARCH PORTFOLIO, OUR MISSIONS 4071 02:30:55,076 --> 02:30:56,043 TO EXPAND THAT MAKE SURE WOMEN 4072 02:30:56,043 --> 02:31:01,349 ARE INCLUDED I AND SUPPORT WOMEN 4073 02:31:01,349 --> 02:31:01,916 AND STEM CAREERS AS WELL. 4074 02:31:01,916 --> 02:31:05,519 WE HAVE LED THE DEVELOPMENT WITH 4075 02:31:05,519 --> 02:31:07,255 MUCH INPUT FROM KEY INTERESTED 4076 02:31:07,255 --> 02:31:08,689 PERSONS INSIDE AND OUTSIDE OF 4077 02:31:08,689 --> 02:31:11,392 NIH IN THE NEW NIH STRATEGIC 4078 02:31:11,392 --> 02:31:12,393 PLAN FOR WOMEN'S HEALTH 4079 02:31:12,393 --> 02:31:13,060 RESEARCH. 4080 02:31:13,060 --> 02:31:14,562 WE HAVE GOALS AND OBJECTIVES 4081 02:31:14,562 --> 02:31:15,863 THERE THAT WE ARE COLLECTIVELY 4082 02:31:15,863 --> 02:31:18,833 WORKING TOGETHER AS AN AGENCY TO 4083 02:31:18,833 --> 02:31:20,101 MEET PRIORITY SETTING BY 4084 02:31:20,101 --> 02:31:21,636 DEVELOPING FUNDING 4085 02:31:21,636 --> 02:31:22,737 OPPORTUNITIES. 4086 02:31:22,737 --> 02:31:23,838 WE HIGHLIGHT THIS 4087 02:31:23,838 --> 02:31:24,905 MULTIDIMENSIONAL FRAMEWORK AS 4088 02:31:24,905 --> 02:31:26,207 FRONT AND CENTER, THE WAY WE 4089 02:31:26,207 --> 02:31:28,242 THINK ABOUT THE HEALTH OF WOMEN 4090 02:31:28,242 --> 02:31:31,212 BEING CRITICAL TO CONSIDER A 4091 02:31:31,212 --> 02:31:32,079 LIFECOURSE PERSPECTIVE, 4092 02:31:32,079 --> 02:31:33,247 RECOGNIZING THAT EVERYTHING THAT 4093 02:31:33,247 --> 02:31:35,549 CAME BEFORE CAN AFFECT THE 4094 02:31:35,549 --> 02:31:38,386 WOMAN'S HEALTH TODAY, AND 4095 02:31:38,386 --> 02:31:39,720 CONSIDERING THE FULL 4096 02:31:39,720 --> 02:31:41,422 CONSTELLATION OF FACTORS, BOTH 4097 02:31:41,422 --> 02:31:43,758 INTERNAL SUCH AS BIOLOGICAL 4098 02:31:43,758 --> 02:31:45,926 FACTORS, EXTERNAL, WHETHER 4099 02:31:45,926 --> 02:31:47,995 THAT'S A TOXICANT EXPOSURE OR A 4100 02:31:47,995 --> 02:31:50,264 TOXIC RELATIONSHIP, ALL OF THOSE 4101 02:31:50,264 --> 02:31:52,266 COMBINE WITH BIOLOGY TO AFFECT 4102 02:31:52,266 --> 02:31:53,768 THE HEALTH OF WOMEN AND WE MUST 4103 02:31:53,768 --> 02:31:55,903 CONSIDER ALL OF THEM IN ORDER TO 4104 02:31:55,903 --> 02:31:58,005 HAVE THE FULL PICTURE AND TO 4105 02:31:58,005 --> 02:32:02,143 HAVE THE FULL IMPACT. 4106 02:32:02,143 --> 02:32:03,311 AND HERE'S A COUPLE OF EXAMPLES 4107 02:32:03,311 --> 02:32:06,947 IN TERMS OF HOW THAT PLAYS 4108 02:32:06,947 --> 02:32:08,482 OUTMENT WE DO SEE THAT ONE 4109 02:32:08,482 --> 02:32:11,018 QUARTER OF WOMEN IN THE UNITED 4110 02:32:11,018 --> 02:32:12,586 STATES EXPERIENCE SEVERE 4111 02:32:12,586 --> 02:32:13,387 PHYSICAL INTIMATE PARTNER 4112 02:32:13,387 --> 02:32:17,091 VIOLENCE IN THEIR LIFETIME. 4113 02:32:17,091 --> 02:32:17,525 ONE QUARTER. 4114 02:32:17,525 --> 02:32:19,360 AND BECAUSE OF SWAN, WE ARE ABLE 4115 02:32:19,360 --> 02:32:24,098 TO HAVE THESE NEW FINDINGS THAT 4116 02:32:24,098 --> 02:32:25,066 WOMEN WHO ARE EXPERIENCED 4117 02:32:25,066 --> 02:32:30,371 PHYSICAL IPV ALSO SAW A DECLINE 4118 02:32:30,371 --> 02:32:32,606 IN THEIR WORKING MEMORY DURING 4119 02:32:32,606 --> 02:32:33,207 THE MENOPAUSAL TRANSITION. 4120 02:32:33,207 --> 02:32:35,743 THIS IS AN EXAMPLE OF HOW THE 4121 02:32:35,743 --> 02:32:36,544 LIFECOURSE PERSPECTIVE MUST BE 4122 02:32:36,544 --> 02:32:37,611 APPLIED AND THE BENEFITS TO 4123 02:32:37,611 --> 02:32:41,315 APPLYING THAT PERSPECTIVE. 4124 02:32:41,315 --> 02:32:42,316 OF COURSE SWAN IS A LARGE STUDY 4125 02:32:42,316 --> 02:32:44,385 AND THIS ONE WAS A SUBSET OF THE 4126 02:32:44,385 --> 02:32:46,120 OVER 3,000 PARTICIPANTS, AND 4127 02:32:46,120 --> 02:32:47,755 HERE AT THE MOST RECENT 4128 02:32:47,755 --> 02:32:48,956 MENOPAUSE SOCIETY MEETING JUST A 4129 02:32:48,956 --> 02:32:52,226 FEW WEEKS AGO, A SMALLER STUDY, 4130 02:32:52,226 --> 02:32:53,828 THE PAN OVARIAN AGING STUDY, 4131 02:32:53,828 --> 02:32:55,796 FOUND THAT ADVERSE CHILDHOOD 4132 02:32:55,796 --> 02:32:57,098 EXPERIENCES GREATER THAN EQUAL 4133 02:32:57,098 --> 02:32:59,333 TO TWO OF THOSE WERE ASSOCIATED 4134 02:32:59,333 --> 02:33:00,801 WITH WORSE IMMEDIATE VERBAL AND 4135 02:33:00,801 --> 02:33:04,939 DELAYED VERBAL RECALL IN THE 4136 02:33:04,939 --> 02:33:06,240 MENOPAUSAL TRANSITION. 4137 02:33:06,240 --> 02:33:07,274 SO CLEARLY SOMETHING IS 4138 02:33:07,274 --> 02:33:08,809 HAPPENING IN TERMS OF MEMORY 4139 02:33:08,809 --> 02:33:10,344 COGNITION AND RELATED TO 4140 02:33:10,344 --> 02:33:12,747 VIOLENCE AND TRAUMA IN PREVIOUS 4141 02:33:12,747 --> 02:33:13,013 EXPOSURE. 4142 02:33:13,013 --> 02:33:13,581 WE NEED TO UNDERSTAND THAT 4143 02:33:13,581 --> 02:33:15,516 BETTER. 4144 02:33:15,516 --> 02:33:19,019 I WAS ABSOLUTELY HONORED TO BE 4145 02:33:19,019 --> 02:33:21,088 IN THE WHITE HOUSE WHEN 4146 02:33:21,088 --> 02:33:23,991 PRESIDENT BIDEN SIGNED EXECUTIVE 4147 02:33:23,991 --> 02:33:25,960 ORDER 14120 TO ADVANCE WOMEN'S 4148 02:33:25,960 --> 02:33:27,795 HEALTH RESEARCH AND INNOVATION. 4149 02:33:27,795 --> 02:33:29,563 AN INCREDIBLE LANDMARK EFFORT, 4150 02:33:29,563 --> 02:33:32,600 THE LARGEST AND BROADEST EVER 4151 02:33:32,600 --> 02:33:33,834 EXECUTIVE ACTION RELATED TO 4152 02:33:33,834 --> 02:33:35,236 WOMEN'S HEALTH RESEARCH. 4153 02:33:35,236 --> 02:33:36,670 THE FOUR COMPONENTS ARE LISTED 4154 02:33:36,670 --> 02:33:37,772 HERE. 4155 02:33:37,772 --> 02:33:39,073 PRIORITIZING INVESTMENTS ACROSS 4156 02:33:39,073 --> 02:33:41,942 THE FEDERAL PORTFOLIO 4157 02:33:41,942 --> 02:33:43,144 INTEGRATING GALVANIZING NEW 4158 02:33:43,144 --> 02:33:45,312 RESEARCH TO SUPPORT WOMEN'S MID 4159 02:33:45,312 --> 02:33:47,481 LIFE HEALTH, AND THEN ASSESSING 4160 02:33:47,481 --> 02:33:49,450 UNMET NEEDS. 4161 02:33:49,450 --> 02:33:50,985 I'VE BEEN WORKING ACROSS NIH AND 4162 02:33:50,985 --> 02:33:52,486 OTHER AGENCIES TO DO THAT, AND 4163 02:33:52,486 --> 02:33:53,587 I'LL BE TELLING YOU A LITTLE BIT 4164 02:33:53,587 --> 02:33:55,256 ABOUT THAT LATER ON. 4165 02:33:55,256 --> 02:33:56,891 WHY IS THIS MENOPAUSAL 4166 02:33:56,891 --> 02:33:58,626 TRANSITION SO IMPORTANT? 4167 02:33:58,626 --> 02:34:00,294 IT'S AT THAT TIME PERIOD, WHICH 4168 02:34:00,294 --> 02:34:02,096 IS A CRITICAL JUNCTURE, WHERE WE 4169 02:34:02,096 --> 02:34:04,465 SEE CHRONIC LOGICAL, BIOLOGICAL 4170 02:34:04,465 --> 02:34:07,535 AND REPRODUCTIVE AGING COMING 4171 02:34:07,535 --> 02:34:07,802 TOGETHER. 4172 02:34:07,802 --> 02:34:10,504 WE RECOGNIZE THE EFFECTS OF 4173 02:34:10,504 --> 02:34:12,039 CHRONOLOGICAL AGING FOR EXAMPLE 4174 02:34:12,039 --> 02:34:13,507 IN TERMS OF INSULIN RESISTANCE, 4175 02:34:13,507 --> 02:34:15,709 BUT WE ALSO SEE OVARIAN AGING 4176 02:34:15,709 --> 02:34:17,278 CONSEQUENCES, WE SEE THE 4177 02:34:17,278 --> 02:34:18,212 INTERSECTION OF THE TWO, AND 4178 02:34:18,212 --> 02:34:19,747 THEN WE SEE THINGS WE DON'T 4179 02:34:19,747 --> 02:34:21,515 UNDERSTAND AS TO WHY, FOR 4180 02:34:21,515 --> 02:34:24,151 EXAMPLE, METABOLIC SYNDROME 4181 02:34:24,151 --> 02:34:25,219 IS -- ITS SEVERITY INCREASES 4182 02:34:25,219 --> 02:34:26,220 RIGHT AT THE MENOPAUSAL 4183 02:34:26,220 --> 02:34:26,520 TRANSITION. 4184 02:34:26,520 --> 02:34:28,289 IS THAT AN AGE EFFECT, IS THAT 4185 02:34:28,289 --> 02:34:29,156 AN OVARIAN EFFECT? 4186 02:34:29,156 --> 02:34:29,790 WE HAVE QUESTIONS. 4187 02:34:29,790 --> 02:34:34,028 AND WE CLEARLY NEED TO ANSWER 4188 02:34:34,028 --> 02:34:36,230 THEM. 4189 02:34:36,230 --> 02:34:38,265 I USUALLY SHOW THIS AT THE 4190 02:34:38,265 --> 02:34:42,837 BEGINNING OF WOMEN'S MEDLINE 4191 02:34:42,837 --> 02:34:44,205 HEALTH TALKS TO BRING HOME HOW 4192 02:34:44,205 --> 02:34:47,007 AGE IS NOT THE ONLY WAY -- 4193 02:34:47,007 --> 02:34:47,575 CHRONOLOGICAL AGE IS NOT THE 4194 02:34:47,575 --> 02:34:48,742 ONLY WAY WE AGE AND IT'S NOT THE 4195 02:34:48,742 --> 02:34:50,945 ONLY FACTOR IMPORTANT FOR THE 4196 02:34:50,945 --> 02:34:52,480 DEVELOPMENT OF CHRONIC DISEASE 4197 02:34:52,480 --> 02:34:53,147 BECAUSE WE KNOW THAT TRANSITION 4198 02:34:53,147 --> 02:34:54,348 IS AN IMPORTANT PERIOD OF TIME 4199 02:34:54,348 --> 02:34:55,883 AND THAT REPRESENTS AN 4200 02:34:55,883 --> 02:34:57,184 INFLECTION POINT FOR INCREASED 4201 02:34:57,184 --> 02:34:58,185 RISK OF CARDIOVASCULAR DISEASE 4202 02:34:58,185 --> 02:34:58,786 IN PARTICULAR. 4203 02:34:58,786 --> 02:35:01,288 THIS DATA SHOWS CARDIOVASCULAR 4204 02:35:01,288 --> 02:35:03,657 DISEASE INCIDENCE FOR WOMEN 4205 02:35:03,657 --> 02:35:04,558 DIFFERENT AGES HERE IN THE 4206 02:35:04,558 --> 02:35:05,993 CENTER, AND WHETHER THEY'RE 4207 02:35:05,993 --> 02:35:07,528 PREMENOPAUSAL VERSUS 4208 02:35:07,528 --> 02:35:07,895 POST-MENOPAUSAL. 4209 02:35:07,895 --> 02:35:09,463 AND YOU CAN SEE AT EVERY AGE, 4210 02:35:09,463 --> 02:35:10,998 HIGHER RATES OF CARDIOVASCULAR 4211 02:35:10,998 --> 02:35:14,502 DISEASE INCIDENCE FOR SAME 4212 02:35:14,502 --> 02:35:16,103 CHRONOLOGICAL AGE WOMEN WHO ARE 4213 02:35:16,103 --> 02:35:17,037 POST-MENOPAUSAL. 4214 02:35:17,037 --> 02:35:17,738 SO THERE'S CLEAR EVIDENCE FOR 4215 02:35:17,738 --> 02:35:19,173 THAT. 4216 02:35:19,173 --> 02:35:20,808 OTHER STUDIES AGAIN SUPPORTED BY 4217 02:35:20,808 --> 02:35:22,943 SWAN HERE LOOKING AT VASOMOTOR 4218 02:35:22,943 --> 02:35:24,712 SYMPTOMS, BECAUSE WE DO KNOW 4219 02:35:24,712 --> 02:35:27,548 THAT CARDIOVASCULAR DISEASE IN 4220 02:35:27,548 --> 02:35:29,483 WOMEN HAS UNIQUE FE FEATURES. 4221 02:35:29,483 --> 02:35:31,018 SOME OF THEM ARE ASSOCIATED WITH 4222 02:35:31,018 --> 02:35:31,919 REPRODUCTIVE FACTORS AND WE 4223 02:35:31,919 --> 02:35:32,953 DON'T UNDERSTAND EVERYTHING 4224 02:35:32,953 --> 02:35:34,622 ABOUT THEM. 4225 02:35:34,622 --> 02:35:35,923 BUT VASOMOTOR SYMPTOMS WHICH 80% 4226 02:35:35,923 --> 02:35:38,559 OF WOMEN EXPERIENCE HAVE BEEN 4227 02:35:38,559 --> 02:35:39,960 LINKED TO CARDIOVASCULAR DISEASE 4228 02:35:39,960 --> 02:35:40,828 RISK AND HERE'S ONE OF THE 4229 02:35:40,828 --> 02:35:42,696 STUDIES THAT SHOW THAT. 4230 02:35:42,696 --> 02:35:45,099 FREQUENT AND PERSISTENT 4231 02:35:45,099 --> 02:35:45,599 VASOMOTOR SYMPTOMS WERE 4232 02:35:45,599 --> 02:35:46,834 ASSOCIATED WITH INCREASED RISK 4233 02:35:46,834 --> 02:35:49,570 OF LATER CARDIOVASCULAR DISEASE 4234 02:35:49,570 --> 02:35:49,904 EVENTS. 4235 02:35:49,904 --> 02:35:53,407 SO THIS IS A NOVEL 4236 02:35:53,407 --> 02:35:54,708 FEMALE-SPECIFIC CVD RISK FACTOR 4237 02:35:54,708 --> 02:35:55,709 AND IT GIVES US AN OPPORTUNITY 4238 02:35:55,709 --> 02:35:57,344 TO INTERVENE. 4239 02:35:57,344 --> 02:35:58,412 WE DO ALSO KNOW THAT WOMEN TEND 4240 02:35:58,412 --> 02:35:59,947 TO HAVE MORE CHRONIC DISEASES 4241 02:35:59,947 --> 02:36:02,149 THAN MEN DO. 4242 02:36:02,149 --> 02:36:03,717 MULTI-MORBIDITY AND THE GRAPH ON 4243 02:36:03,717 --> 02:36:05,553 THE LEFT HIGHLIGHTS THE FACT 4244 02:36:05,553 --> 02:36:06,587 THAT FOR ALL OF THESE DIFFERENT 4245 02:36:06,587 --> 02:36:08,489 RACIAL AND ETHNIC GROUPS, THE 4246 02:36:08,489 --> 02:36:11,892 RATES FOR WOMEN OF OVER TWO 4247 02:36:11,892 --> 02:36:12,860 CHRONIC CONDITIONS EXCEED THOSE 4248 02:36:12,860 --> 02:36:13,861 OF MEN. 4249 02:36:13,861 --> 02:36:14,962 OVER ON THE RIGHT THE COMPLEXITY 4250 02:36:14,962 --> 02:36:16,931 OF THE NETWORKS OF CONNECTIONS 4251 02:36:16,931 --> 02:36:18,198 BETWEEN THESE CO-MORBIDITIES IS 4252 02:36:18,198 --> 02:36:19,733 MORE DETAILED IN WOMEN THAN IN 4253 02:36:19,733 --> 02:36:21,802 MEN, AND THEN THE BOTTOM HERE 4254 02:36:21,802 --> 02:36:23,971 BASICALLY SHOWING THAT THEY'RE 4255 02:36:23,971 --> 02:36:28,776 MORE DISCORDANT, MEANING SOMATIC 4256 02:36:28,776 --> 02:36:30,377 AND PSYCHIATRIC COMORBIDITIES AS 4257 02:36:30,377 --> 02:36:31,812 WELL AS DIFFERENT ORGAN SYSTEMS 4258 02:36:31,812 --> 02:36:33,814 INVOLVED IN CHRONIC DISEASE 4259 02:36:33,814 --> 02:36:34,548 COMORBIDITIES IN WOMEN AS 4260 02:36:34,548 --> 02:36:36,684 COMPARED TO MEN. 4261 02:36:36,684 --> 02:36:38,218 IMPORTANT ISSUE FOR WOMEN AND 4262 02:36:38,218 --> 02:36:39,520 MEN TO ADDRESS THE 4263 02:36:39,520 --> 02:36:42,289 MULTI-MORBIDITY PROBLEM. 4264 02:36:42,289 --> 02:36:43,591 IN TERMS OF THE MENOPAUSE 4265 02:36:43,591 --> 02:36:45,059 RESEARCH THAT NIH HAS SUPPORTED, 4266 02:36:45,059 --> 02:36:48,262 OF COURSE NIA HAS BEEN THE 4267 02:36:48,262 --> 02:36:50,664 LEADER, AND MS. BRAIN, MS. FLASH 4268 02:36:50,664 --> 02:36:52,833 ARE OTHER EXAMPLES OF REALLY 4269 02:36:52,833 --> 02:36:53,834 THOUGHTFUL APPROACHES TO 4270 02:36:53,834 --> 02:36:57,338 IDENTIFYING THERAPEUTIC TARGETS, 4271 02:36:57,338 --> 02:36:59,840 TESTING, STRATEGIES, AND WE WERE 4272 02:36:59,840 --> 02:37:01,108 THRILLED TO BE ABLE TO HIGHLIGHT 4273 02:37:01,108 --> 02:37:02,576 THIS WORK IN 2022, WITH ONE OFF 4274 02:37:02,576 --> 02:37:05,179 UR QUARTERLY PUBLICATIONS CALLED 4275 02:37:05,179 --> 02:37:06,046 WOMEN HEALTH IN FOCUS. 4276 02:37:06,046 --> 02:37:08,949 THEN IN 2023, OUR ANNUAL 4277 02:37:08,949 --> 02:37:09,883 RECOGNITION, NIH'S ANNUAL 4278 02:37:09,883 --> 02:37:11,418 RECOGNITION OF NATIONAL WOMEN'S 4279 02:37:11,418 --> 02:37:14,054 HEALTH WEEK, THE VIVIAN 4280 02:37:14,054 --> 02:37:15,956 PALESTVIF 4281 02:37:16,390 --> 02:37:21,028 THE VIVIAN PINN SYMPOSIUM 4282 02:37:21,028 --> 02:37:26,033 FOCUSED JUST ON MID LIFE HEALTH 4283 02:37:26,033 --> 02:37:27,501 OF WOMEN AND MENOPAUSE THOSE 4284 02:37:27,501 --> 02:37:29,003 MATERIALS ARE AVAILABLE ON THE 4285 02:37:29,003 --> 02:37:29,536 WEBSITE. 4286 02:37:29,536 --> 02:37:30,671 I'VE BEEN HERE BEFORE WITH 4287 02:37:30,671 --> 02:37:33,140 RICHARD HIGH YOU LIGHTING THE 4288 02:37:33,140 --> 02:37:34,241 CRITICAL NATURE OF ACCOUNTING 4289 02:37:34,241 --> 02:37:35,909 FOR SEX AS A BIOLOGICAL VARIABLE 4290 02:37:35,909 --> 02:37:37,177 AND EVERYTHING WE DO AND HOW 4291 02:37:37,177 --> 02:37:37,945 THAT BENEFITS ALL OF US. 4292 02:37:37,945 --> 02:37:43,117 SO THE INNOVATIONS TESTING 4293 02:37:43,117 --> 02:37:44,318 PROGRAM PROGRAM BEGAN LONG 4294 02:37:44,318 --> 02:37:47,154 BEFORE SABB AND WAS EVEN AN 4295 02:37:47,154 --> 02:37:49,556 ARTICULATION RIGOROUSLY INCLUDED 4296 02:37:49,556 --> 02:37:51,525 MALES AND FEMALES AND LOOKED AT 4297 02:37:51,525 --> 02:37:51,825 DIFFERENCES. 4298 02:37:51,825 --> 02:37:52,893 HERE'S JUST AN EXAMPLE WITH 4299 02:37:52,893 --> 02:37:54,294 RAPAMYCIN SHOWING DIFFERENCES IN 4300 02:37:54,294 --> 02:37:55,295 DOSAGE AND DURATION AND YOU KNOW 4301 02:37:55,295 --> 02:37:59,600 THIS VERY THOUGHTFULLY TAKING 4302 02:37:59,600 --> 02:38:01,468 INTO CONSIDER THE STANDARDIZED 4303 02:38:01,468 --> 02:38:02,803 APPROACH AND PROTOCOLS THAT ARE 4304 02:38:02,803 --> 02:38:03,504 EVALUATED. 4305 02:38:03,504 --> 02:38:05,539 SO BEYOND SABV, IT'S NOT JUST 4306 02:38:05,539 --> 02:38:06,874 ABOUT SEX DIFFERENCES, IT'S 4307 02:38:06,874 --> 02:38:08,275 ALWAYS ABOUT FEMALE SPECIFIC 4308 02:38:08,275 --> 02:38:10,277 ISSUES BUT I ALWAYS LIKE TO 4309 02:38:10,277 --> 02:38:11,445 INCLUDE SEX DIFFERENCES AS WELL 4310 02:38:11,445 --> 02:38:12,246 BECAUSE THAT'S A PART OF THE 4311 02:38:12,246 --> 02:38:13,013 STORY AS WELL. 4312 02:38:13,013 --> 02:38:14,415 I'M ALSO EXCITED TO SHARE WITH 4313 02:38:14,415 --> 02:38:16,617 YOU THAT AS OF FY 23, NIH NOW 4314 02:38:16,617 --> 02:38:19,453 HAS AN RCDC TERM RESEARCH 4315 02:38:19,453 --> 02:38:20,654 CONDITION AND DISEASE CATEGORY 4316 02:38:20,654 --> 02:38:22,856 TERM THAT WILL -- FOR MENOPAUSE 4317 02:38:22,856 --> 02:38:24,892 RESEARCH THAT ALLOWS US TO 4318 02:38:24,892 --> 02:38:27,428 CAPTURE AND TRACK OUR 4319 02:38:27,428 --> 02:38:27,761 INVESTMENTS. 4320 02:38:27,761 --> 02:38:30,030 YOU'RE NOT SURPRISED TO SEE THE 4321 02:38:30,030 --> 02:38:32,666 ROYAL BLUE THAT FOR FY 23, THE 4322 02:38:32,666 --> 02:38:34,334 NATIONAL INSTITUTE ON AGING 4323 02:38:34,334 --> 02:38:36,637 SUPPORTED 58%, NEARLY 60% OF 4324 02:38:36,637 --> 02:38:39,373 NIH'S MENOPAUSE RESEARCH CODED 4325 02:38:39,373 --> 02:38:40,908 BY RCDC. 4326 02:38:40,908 --> 02:38:44,712 YOU SEE NIMH AT 11%, HEART, LUNG 4327 02:38:44,712 --> 02:38:47,715 AND BLOOD AT 8%, DIABETES, 4328 02:38:47,715 --> 02:38:49,249 DIGESTIVE AND KIDNEY DISEASES AT 4329 02:38:49,249 --> 02:38:51,085 4% AND ALMOST 20% OTHER 4330 02:38:51,085 --> 02:38:52,052 INSTITUTES TOGETHER. 4331 02:38:52,052 --> 02:38:53,721 BUT I'M GOING TO HIGHLIGHT FOR 4332 02:38:53,721 --> 02:38:57,624 YOU THE FACT THAT THAT DOESN'T 4333 02:38:57,624 --> 02:38:59,193 TELL THE FULL STORY. 4334 02:38:59,193 --> 02:39:02,029 IN FACT, THIS DATA IS FROM A 4335 02:39:02,029 --> 02:39:03,797 REPORTER USING THAT SAME FQ23 4336 02:39:03,797 --> 02:39:05,432 DATASET AND YOU CAN SEE IN TERMS 4337 02:39:05,432 --> 02:39:07,801 OF THE TOM IX ADDRESSED RANGING 4338 02:39:07,801 --> 02:39:09,069 FROM SEX DIFFERENCES FOR EXAMPLE 4339 02:39:09,069 --> 02:39:13,774 IN THE BRAIN, HORMONES, 4340 02:39:13,774 --> 02:39:15,275 ALZHEIMER'S, BREAST CANCER, LONG 4341 02:39:15,275 --> 02:39:16,443 TERM AND CLINICAL TRIALS YOU SEE 4342 02:39:16,443 --> 02:39:17,778 ALL OF THOSE PROJECT AREAS AND 4343 02:39:17,778 --> 02:39:21,014 THEY WERE FUNDED BY ALL OF THOSE 4344 02:39:21,014 --> 02:39:21,615 INSTITUTES LISTED THERE. 4345 02:39:21,615 --> 02:39:23,584 SO IT IS A BROAD TOPIC, WE ALL 4346 02:39:23,584 --> 02:39:24,885 KNOW, AND WE HAVE MULTIPLE 4347 02:39:24,885 --> 02:39:25,652 INSTITUTES AND CENTERS 4348 02:39:25,652 --> 02:39:27,321 ADDRESSING IT FROM VARIOUS 4349 02:39:27,321 --> 02:39:30,624 ADVANTAGE TAJ POINTS A 4350 02:39:30,624 --> 02:39:32,025 VANTAGE POINTS ALIGNED FROM 4351 02:39:32,025 --> 02:39:32,993 THEIR AREAS AND THAT'S 4352 02:39:32,993 --> 02:39:33,260 IMPORTANT. 4353 02:39:33,260 --> 02:39:35,229 WE ALSO REALIZED CARDIOVASCULAR 4354 02:39:35,229 --> 02:39:36,563 DISEASE IS THE LEADING CAUSE OF 4355 02:39:36,563 --> 02:39:38,198 DEATH IN WOMEN WORLDWIDE, CAUSES 4356 02:39:38,198 --> 02:39:39,600 MORE DEATHS THAN ALL CANCERS 4357 02:39:39,600 --> 02:39:42,236 COMBINED AND WE KNOW THERE ARE 4358 02:39:42,236 --> 02:39:43,470 CARDIOMETABOLIC CHANGES THAT 4359 02:39:43,470 --> 02:39:44,138 OCCUR DURING THE MENOPAUSAL 4360 02:39:44,138 --> 02:39:45,339 TRANSITION, THAT THAT 4361 02:39:45,339 --> 02:39:46,206 PERIMENOPAUSE, LATE MENOPAUSE, 4362 02:39:46,206 --> 02:39:47,708 THOSE ARE DIFFERENT, THAT THIS 4363 02:39:47,708 --> 02:39:49,042 IS A TRANSITION WITH DIFFERENT 4364 02:39:49,042 --> 02:39:49,409 CHARACTERISTICS. 4365 02:39:49,409 --> 02:39:50,778 I'M NOT GOING TO GO THROUGH ALL 4366 02:39:50,778 --> 02:39:51,779 THIS INFORMATION HERE BECAUSE 4367 02:39:51,779 --> 02:39:53,814 IT'S WELL-KNOWN TO YOU, BUT YOU 4368 02:39:53,814 --> 02:39:57,317 KNOW, WE SEE THE DECREASE IN 4369 02:39:57,317 --> 02:39:59,186 ESTROGEN AND INCREASE IN FSH 4370 02:39:59,186 --> 02:40:01,355 ASSOCIATED WITH INCREASE IN 4371 02:40:01,355 --> 02:40:02,656 ADIPOSITY, WHETHER THAT'S 4372 02:40:02,656 --> 02:40:03,557 SUBCUTANEOUS OR VISCERAL, 4373 02:40:03,557 --> 02:40:05,359 CHANGES IN SLEEP PATTERNS, 4374 02:40:05,359 --> 02:40:08,562 CHANGES IN M METABOLISM, FAT 4375 02:40:08,562 --> 02:40:10,097 OXIDATION, FOR EXAMPLE, 4376 02:40:10,097 --> 02:40:11,098 ENDOTHELIAL DYSFUNCTION, 4377 02:40:11,098 --> 02:40:11,732 VASCULAR REMODELING. 4378 02:40:11,732 --> 02:40:14,434 LOTS OF THINGS ARE CHANGING AT 4379 02:40:14,434 --> 02:40:17,171 THE SAME TIME AS CHRONOLOGY IS 4380 02:40:17,171 --> 02:40:18,405 PROGRESSING RELATED TO 4381 02:40:18,405 --> 02:40:18,705 MENOPAUSE. 4382 02:40:18,705 --> 02:40:20,741 SO WHEN YOU SEE GRAPHS LIKE 4383 02:40:20,741 --> 02:40:24,278 THIS, THIS IS WORK BY ROBBY DIAZ 4384 02:40:24,278 --> 02:40:27,014 WHO PRESENTED AT OUR MOST RECENT 4385 02:40:27,014 --> 02:40:27,981 ADVISORY COMMITTEE MEETING ON 4386 02:40:27,981 --> 02:40:29,349 CHANGES IN METABOLISM IN THE 4387 02:40:29,349 --> 02:40:32,286 BRAIN, WHERE YOU SEE GLUCOSE 4388 02:40:32,286 --> 02:40:33,487 METABOLISM CLEARLY GOING DOWN 4389 02:40:33,487 --> 02:40:35,756 AND OTHER CHANGES, YOU'RE NOT 4390 02:40:35,756 --> 02:40:36,323 SURPRISED. 4391 02:40:36,323 --> 02:40:37,858 I ACTUALLY SIMPLIFIED HER SLIDE. 4392 02:40:37,858 --> 02:40:41,461 SHE HAS ABOUT 12 DIFFERENT LINES 4393 02:40:41,461 --> 02:40:42,529 IN DIFFERENT DIRECTS OF ALL THE 4394 02:40:42,529 --> 02:40:43,764 CHANGES GOING ON IN THE BRAIN 4395 02:40:43,764 --> 02:40:46,400 DURING THAT TRANSITION. 4396 02:40:46,400 --> 02:40:48,168 SO WE REALLY NEED TO TAKE INTO 4397 02:40:48,168 --> 02:40:50,204 EFFECT THE COMPLEXITY OF THE 4398 02:40:50,204 --> 02:40:51,605 TRANSITION, AND THE FACT THAT IT 4399 02:40:51,605 --> 02:40:53,373 OCCURS IN DIFFERENT WAYS IN 4400 02:40:53,373 --> 02:40:54,441 DIFFERENT ORGANS AND IN 4401 02:40:54,441 --> 02:40:54,975 DIFFERENT CELL TYPES. 4402 02:40:54,975 --> 02:40:56,410 SO IN TERMS OF BONE HEALTH, 4403 02:40:56,410 --> 02:41:03,617 ANOTHER REALLY IMPORTANT TOPIC, 4404 02:41:03,617 --> 02:41:05,586 DR. SHERRI-ANN BURNETT-BOWIE 4405 02:41:05,586 --> 02:41:09,289 TALKED ABOUT HOWL WE DO SEE 4406 02:41:09,289 --> 02:41:10,591 ASSOCIATED BONE LOSS AND 4407 02:41:10,591 --> 02:41:11,258 INCREASED FRACTURE RISK. 4408 02:41:11,258 --> 02:41:14,194 WE DORC DON'T KNOW EVERYTHING WD 4409 02:41:14,194 --> 02:41:15,529 TO KNOW ABOUT THAT. 4410 02:41:15,529 --> 02:41:18,365 STUDIES LIKE MOTRPAC AND THOSE 4411 02:41:18,365 --> 02:41:20,634 TWO PARs NIA HAS PUT OUT 4412 02:41:20,634 --> 02:41:21,735 LOOKING AT SEX AND GENDER 4413 02:41:21,735 --> 02:41:22,736 DIFFERENCES IN ALZHEIMER'S 4414 02:41:22,736 --> 02:41:23,503 DISEASE HIGHLIGHT ALL OF THE 4415 02:41:23,503 --> 02:41:28,208 WAYS THAT NIH IS SUPPORTING 4416 02:41:28,208 --> 02:41:29,943 SCIENTISTS TO LOOK FOR SEX 4417 02:41:29,943 --> 02:41:31,044 DIFFERENCES AND TRY AND 4418 02:41:31,044 --> 02:41:32,346 UNDERSTAND WHAT WE SEE WHEN WE 4419 02:41:32,346 --> 02:41:33,146 FIND THEM. 4420 02:41:33,146 --> 02:41:34,147 WE'RE FINDING A LOT OF THEM, AND 4421 02:41:34,147 --> 02:41:37,851 I THINK THAT GIVES US ROBUST 4422 02:41:37,851 --> 02:41:39,620 SUBSTRATE FOR THE NEXT 10 YEARS 4423 02:41:39,620 --> 02:41:40,721 TO TRY TO CHARACTERIZE WHAT THEY 4424 02:41:40,721 --> 02:41:42,356 MEAN AND THE MOLECULAR 4425 02:41:42,356 --> 02:41:43,891 UNDERPINNINGS OF THOSE SEX 4426 02:41:43,891 --> 02:41:44,191 DIFFERENCES. 4427 02:41:44,191 --> 02:41:46,293 SO AT ORWH, WE ACTUALLY LEAD 4428 02:41:46,293 --> 02:41:49,329 NIH'S ONLY DISEASE-AGNOSTIC SEX 4429 02:41:49,329 --> 02:41:50,797 DIFFERENCES CENTER-LEVEL PROGRAM 4430 02:41:50,797 --> 02:41:52,099 CALLED THE SPECIALIZED CENTERS 4431 02:41:52,099 --> 02:41:54,835 OF RESEARCH EXCELLENCE ON SEX 4432 02:41:54,835 --> 02:41:55,969 DIFFERENCES OR SCORE. 4433 02:41:55,969 --> 02:41:57,537 THIS PROGRAM HAS A BASIC SCIENCE 4434 02:41:57,537 --> 02:41:59,039 COMPONENT, A TRANSLATIONAL 4435 02:41:59,039 --> 02:42:00,440 COMPONENT, A CLINICAL COMPONENT, 4436 02:42:00,440 --> 02:42:01,909 AND A CAREER ENHANCEMENT CORE 4437 02:42:01,909 --> 02:42:04,311 WHERE WE'RE NOW SUPPORTING PILOT 4438 02:42:04,311 --> 02:42:06,146 STUDIES FOR INVESTIGATORS. 4439 02:42:06,146 --> 02:42:07,614 THESE ARE THE SCIENTISTS THAT 4440 02:42:07,614 --> 02:42:09,349 ARE DEEP INTO SEX DIFFERENCES 4441 02:42:09,349 --> 02:42:11,418 AND THEY'RE TESTING TOOLS AND 4442 02:42:11,418 --> 02:42:13,186 STRATEGIES LIKE SEX STRATIFIED 4443 02:42:13,186 --> 02:42:15,022 RANDOMIZATION IN THEIR CLINICAL 4444 02:42:15,022 --> 02:42:16,223 STUDIES, STUDIES THAT ARE POWER 4445 02:42:16,223 --> 02:42:19,960 TODAY LOOK FOR SEX DEPENDENT 4446 02:42:19,960 --> 02:42:20,627 EFFECTS, STANDARD SEX 4447 02:42:20,627 --> 02:42:21,495 DISAGGREGATING OF RESULTS AND 4448 02:42:21,495 --> 02:42:22,696 OTHER APPROACHES. 4449 02:42:22,696 --> 02:42:24,031 IT'S OUR PRIVILEGE TO 4450 02:42:24,031 --> 02:42:25,432 COLLABORATE WITH FIVE 4451 02:42:25,432 --> 02:42:26,767 INSTITUTES, CENTERS AND OFFICES 4452 02:42:26,767 --> 02:42:29,903 ON OUR 12 ACTIVE SCORE PROGRAMS. 4453 02:42:29,903 --> 02:42:31,305 HERE ARE THE CURRENT PROGRAMS 4454 02:42:31,305 --> 02:42:33,740 THAT YOU'LL SEE THAT NIA IS THE 4455 02:42:33,740 --> 02:42:35,275 INSTITUTE THAT SUPPORTS THE MOST 4456 02:42:35,275 --> 02:42:38,679 SCORE PROGRAMS WITH SIX HERE, 4457 02:42:38,679 --> 02:42:40,414 AND THE RANGE OF SCIENCE WE'RE 4458 02:42:40,414 --> 02:42:41,381 CONDUCTING AND SUPPORTING 4459 02:42:41,381 --> 02:42:43,150 THROUGH THIS, WHETHER IT'S 4460 02:42:43,150 --> 02:42:45,252 CARDIOMETABOLIC HEALTH OR 4461 02:42:45,252 --> 02:42:49,957 AUTONOMIC DYSREGULATION IN 4462 02:42:49,957 --> 02:42:51,058 PRENATAL STRESS LEADING TO 4463 02:42:51,058 --> 02:42:52,993 DEPRESSION LATER IN LIFE, SEX 4464 02:42:52,993 --> 02:42:53,894 DIFFERENCES IN ALCOHOL USE 4465 02:42:53,894 --> 02:42:55,862 DISORDER OR HYPERTENSION AT 4466 02:42:55,862 --> 02:42:57,297 AUGUSTA UNIVERSITY, WHICH IS OUR 4467 02:42:57,297 --> 02:42:57,631 NEWEST SCORE. 4468 02:42:57,631 --> 02:43:00,267 SO WE ARE DELIGHTED TO BE 4469 02:43:00,267 --> 02:43:01,969 PARTNERING WITH NIA AND HAVE 4470 02:43:01,969 --> 02:43:03,403 PARTNERED FOR MANY, MANY YEARS 4471 02:43:03,403 --> 02:43:05,272 ON THE SPECIALIZED CENTERS OF 4472 02:43:05,272 --> 02:43:06,139 RESEARCH EXCELLENCE ON SEX 4473 02:43:06,139 --> 02:43:06,473 DIFFERENCES. 4474 02:43:06,473 --> 02:43:07,708 I'M GOING TO HIGHLIGHT JUST ONE 4475 02:43:07,708 --> 02:43:11,778 OF THOSE PROGRAMS HERE AND TALK 4476 02:43:11,778 --> 02:43:13,347 TO YOU A LITTLE BIT ABOUT THE 4477 02:43:13,347 --> 02:43:15,415 CLINICAL IMPLICATIONS OF SEX 4478 02:43:15,415 --> 02:43:16,183 DIFFERENCES RESEARCH. 4479 02:43:16,183 --> 02:43:18,151 THIS IS THE CEDARS-SINAI PROGRAM 4480 02:43:18,151 --> 02:43:22,322 WHERE THEY'RE LOOKING AT 4481 02:43:22,322 --> 02:43:26,560 MICROVASCULAR AGING AND 4482 02:43:26,560 --> 02:43:26,994 ICOSINOIDS. 4483 02:43:26,994 --> 02:43:28,128 WE'RE LOOKING AT IMPLICATIONS 4484 02:43:28,128 --> 02:43:28,895 FOR CLINICAL PRACTICE. 4485 02:43:28,895 --> 02:43:30,063 I KNOW THAT GUIDELINES, OF 4486 02:43:30,063 --> 02:43:32,799 COURSE, ARE INFORMED BY RESEARCH 4487 02:43:32,799 --> 02:43:34,101 GENERATED BY AND OFTEN SUPPORTED 4488 02:43:34,101 --> 02:43:35,635 BY NIH AND THEN IN ORDER TO MAKE 4489 02:43:35,635 --> 02:43:38,038 SURE THAT THOSE GUIDELINES ARE 4490 02:43:38,038 --> 02:43:39,239 INFORMED BY EVIDENCE, WE NEED TO 4491 02:43:39,239 --> 02:43:41,708 HAVE THAT SEX-AWARE APPROACH TO 4492 02:43:41,708 --> 02:43:42,642 GENERATING OUR EVIDENCE AND 4493 02:43:42,642 --> 02:43:43,844 MAKING SURE OUR STUDIES ARE 4494 02:43:43,844 --> 02:43:48,048 DESIGNED IN A WAY SO THAT WE CAN 4495 02:43:48,048 --> 02:43:48,682 UNDERSTAND THE OUTCOMES FOR 4496 02:43:48,682 --> 02:43:49,683 WOMEN AND MEN. 4497 02:43:49,683 --> 02:43:52,853 AND DR. NO. 4498 02:43:52,853 --> 02:43:56,456 EL MERZ IS THE DIRECTOR AT THE 4499 02:43:56,456 --> 02:43:57,657 BARBARA STREISAND WOMEN'S HEART 4500 02:43:57,657 --> 02:43:59,526 CENTER AT CEDARS-SINAI, AND SHE 4501 02:43:59,526 --> 02:44:01,395 CHALLENGES US TO THINK ABOUT 4502 02:44:01,395 --> 02:44:02,462 WHETHER CERTAIN KEY CONTRIBUTORS 4503 02:44:02,462 --> 02:44:04,031 ARE BEING MEASURED INADEQUATELY 4504 02:44:04,031 --> 02:44:05,432 OR INCORRECTLY AND WHETHER WE 4505 02:44:05,432 --> 02:44:07,501 NEED TO RETOOL OUR USUAL 4506 02:44:07,501 --> 02:44:08,201 APPROACHES. 4507 02:44:08,201 --> 02:44:11,338 FOR EXAMPLE, HER SCORE FOUND 4508 02:44:11,338 --> 02:44:13,306 THAT NORMAL -- AND WE KNEW THIS 4509 02:44:13,306 --> 02:44:15,575 BEFORE -- BUT SHE FOUND IT IN A 4510 02:44:15,575 --> 02:44:16,777 DEFINITIVE WAY, NORMAL BLOOD 4511 02:44:16,777 --> 02:44:18,645 PRESSURE FOR WOMEN IS LOWER THAN 4512 02:44:18,645 --> 02:44:20,180 NORMAL BLOOD PRESSURE FOR MEN. 4513 02:44:20,180 --> 02:44:21,815 OKAY? 4514 02:44:21,815 --> 02:44:24,351 WELL, SHE LOOKED FURTHER AT THE 4515 02:44:24,351 --> 02:44:26,420 THRESHOLDS FOR HYPERTENSION AND 4516 02:44:26,420 --> 02:44:28,055 THE CARDIOVASCULAR CONSEQUENCES 4517 02:44:28,055 --> 02:44:30,424 OF HYPERTENSION, AND THE 4518 02:44:30,424 --> 02:44:32,592 CARDIOVASCULAR CONSEQUENCES FOR 4519 02:44:32,592 --> 02:44:35,328 HYPERTENSION OCCUR AT LOWER 4520 02:44:35,328 --> 02:44:36,129 SYSTOLIC BLOOD PRESSURE 4521 02:44:36,129 --> 02:44:38,665 THRESHOLDS THAN THEY DO FOR MEN. 4522 02:44:38,665 --> 02:44:40,967 SO MIGHT THAT CHANGE HOW WE 4523 02:44:40,967 --> 02:44:42,602 INTERVENE, AND TREAT 4524 02:44:42,602 --> 02:44:44,104 HYPERTENSION IN WOMEN, NOW THAT 4525 02:44:44,104 --> 02:44:45,338 WE SEE THIS SEX DIFFERENCE IN 4526 02:44:45,338 --> 02:44:48,408 THE CONSEQUENCES OF HYPERTENSION 4527 02:44:48,408 --> 02:44:49,810 IN WOMEN AS OPPOSED TO MEN. 4528 02:44:49,810 --> 02:44:51,878 WE ARE VERY MUCH SUPPORTING A 4529 02:44:51,878 --> 02:44:52,946 WHOLE PERSON APPROACH TO THE 4530 02:44:52,946 --> 02:44:54,681 HEALTH OF WOMEN, AND I'M GOING 4531 02:44:54,681 --> 02:44:56,283 TO TALK TO YOU A LITTLE BIT HERE 4532 02:44:56,283 --> 02:44:56,983 ABOUT WHERE WE'D LIKE TO SEE 4533 02:44:56,983 --> 02:44:58,485 THAT GO WITH MENOPAUSE. 4534 02:44:58,485 --> 02:45:01,321 YOU KNOW, MANY CLINICIANS SEE 4535 02:45:01,321 --> 02:45:03,990 PATIENTS BETWEEN THE AGES OF 40 4536 02:45:03,990 --> 02:45:05,559 AND 55 WHO MAY BE EXPERIENCING 4537 02:45:05,559 --> 02:45:07,861 COGNITIVE CHANGES OR BRAIN FOG, 4538 02:45:07,861 --> 02:45:09,396 PATIENTS THAT MAY BE SAYING ALL 4539 02:45:09,396 --> 02:45:10,964 OF A SUDDEN THERE'S AN ISSUE 4540 02:45:10,964 --> 02:45:13,166 WITH INCONTINENCE OR BONE 4541 02:45:13,166 --> 02:45:15,669 CHANGES, A NEW FRACTURE 4542 02:45:15,669 --> 02:45:17,270 UNEXPECTED WITH MINOR TRAUMA, 4543 02:45:17,270 --> 02:45:20,440 YOU KNOW, PALPITATIONS, IS THIS 4544 02:45:20,440 --> 02:45:23,844 MENOPAUSE, IS THIS ARRHYTHMIA, 4545 02:45:23,844 --> 02:45:25,011 METABOLIC DYSFUNCTION, CHANGES 4546 02:45:25,011 --> 02:45:26,847 IN INSULIN RESISTANCE IN THE 4547 02:45:26,847 --> 02:45:28,615 50s, WEIGHT GAIN, AND THEN, OF 4548 02:45:28,615 --> 02:45:30,951 COURSE, ANXIETY AND MENTAL 4549 02:45:30,951 --> 02:45:36,123 HEALTH ARE INTEGRAL TO MENOPAUSE 4550 02:45:36,123 --> 02:45:37,757 CHANGES IN MID LIFE AND HOT 4551 02:45:37,757 --> 02:45:38,758 FLASHES, THE QUINTESSENTIAL 4552 02:45:38,758 --> 02:45:39,392 MENOPAUSE SYMPTOMS. 4553 02:45:39,392 --> 02:45:40,627 SO CLINICIANS WILL SEE PATIENTS 4554 02:45:40,627 --> 02:45:41,561 AND THEY'LL OFTEN REPORT SOME OF 4555 02:45:41,561 --> 02:45:43,864 THESE SYMPTOMS BUT MENOPAUSE IS 4556 02:45:43,864 --> 02:45:44,865 REALLY POTENTIALLY ALL OF THESE 4557 02:45:44,865 --> 02:45:46,233 SYMPTOMS AND ALL OF THESE ORGAN 4558 02:45:46,233 --> 02:45:48,635 SYSTEMS, AND I SHOWED YOU 4559 02:45:48,635 --> 02:45:52,339 DR. DIAZ BRITAN'S WORK, 4560 02:45:52,339 --> 02:45:53,773 DR. BOWIE'S WORK THAT SYSTEMS 4561 02:45:53,773 --> 02:45:56,243 ORGANS ARE CHANGING BENEATH THIS 4562 02:45:56,243 --> 02:45:57,010 SYSTEM CONSTELLATION AND SOME OF 4563 02:45:57,010 --> 02:45:58,745 THESE SYMPTOMS ARE QUITE 4564 02:45:58,745 --> 02:45:59,045 NONSPECIFIC. 4565 02:45:59,045 --> 02:46:01,681 SO IT MAY BE CHALLENGING TO SAY, 4566 02:46:01,681 --> 02:46:03,283 IS THIS SLEEP DISTURBANCE SLEEP 4567 02:46:03,283 --> 02:46:06,052 AAPNEA THAT NEEDS TO BE TREATED 4568 02:46:06,052 --> 02:46:07,854 OR IS THIS A MENOPAUSE SYMPTOM 4569 02:46:07,854 --> 02:46:09,289 THAT CAN BE MANAGED IN A 4570 02:46:09,289 --> 02:46:09,723 DIFFERENT WAY? 4571 02:46:09,723 --> 02:46:11,424 WHAT ARE THE ECONOMIC 4572 02:46:11,424 --> 02:46:12,092 IMPLICATIONS OF FAILING TO 4573 02:46:12,092 --> 02:46:12,759 ADDRESS THESE? 4574 02:46:12,759 --> 02:46:15,929 PROJECTED BY 2025, 3 MILLION 4575 02:46:15,929 --> 02:46:18,532 FRACTURES, COSTING $25 BILLION. 4576 02:46:18,532 --> 02:46:19,166 PER YEAR. 4577 02:46:19,166 --> 02:46:21,368 AND WITH THE GREATEST RISE 4578 02:46:21,368 --> 02:46:22,569 ANTICIPATED IN INDIVIDUALS WHO 4579 02:46:22,569 --> 02:46:23,837 IDENTIFY AS HISPANIC. 4580 02:46:23,837 --> 02:46:25,605 SO WE NEED TO ADDRESS THIS IN A 4581 02:46:25,605 --> 02:46:28,108 WHOLE PERSON PERSPECTIVE, BOTH 4582 02:46:28,108 --> 02:46:30,844 CLINICALLY AND IN OUR RESEARCH 4583 02:46:30,844 --> 02:46:32,913 IN A COORDINATED AND INTEGRATED 4584 02:46:32,913 --> 02:46:33,213 MANNER. 4585 02:46:33,213 --> 02:46:34,848 WE HAVE NEW APPROACHES. 4586 02:46:34,848 --> 02:46:36,016 SYSTEMS BIOLOGY APPROACHES WILL 4587 02:46:36,016 --> 02:46:38,118 ALLOW US TO BE ABLE TO LOOK 4588 02:46:38,118 --> 02:46:40,620 ACROSS THIS CONTINUUM OF THE 4589 02:46:40,620 --> 02:46:43,857 MENOPAUSE TRANSITION AND 4590 02:46:43,857 --> 02:46:45,192 UNDERSTAND BETTER ALL OF THESE 4591 02:46:45,192 --> 02:46:46,393 FACTORS, EXERCISE, SLEEP, 4592 02:46:46,393 --> 02:46:47,494 NUTRITION, AND LOOK AT THE 4593 02:46:47,494 --> 02:46:48,695 CLINICAL SYNDROMES AND SYMPTOMS 4594 02:46:48,695 --> 02:46:50,830 THAT WOMEN ARE REPORTING TO 4595 02:46:50,830 --> 02:46:52,032 ADDRESS SPECIFICALLY THE HEALTH 4596 02:46:52,032 --> 02:46:53,900 OF WOMEN DURING THIS TRANSITION 4597 02:46:53,900 --> 02:46:56,436 IN A NEW AND TARGETED WAY. 4598 02:46:56,436 --> 02:46:58,638 BECAUSE OF EPIGENETICS, WE NOW 4599 02:46:58,638 --> 02:46:59,839 KNOW, FOR EXAMPLE, METHYLATION 4600 02:46:59,839 --> 02:47:01,341 MAY AFFECT HOW DIFFERENT ORGANS 4601 02:47:01,341 --> 02:47:04,177 ARE AGING AT DIFFERENT RATES AND 4602 02:47:04,177 --> 02:47:05,178 ACCELERATION IN DIFFERENT ORGANS 4603 02:47:05,178 --> 02:47:07,647 BECAUSE OF SEX BIAS GENE 4604 02:47:07,647 --> 02:47:08,982 EXPRESSION, WHICH VIRTUALLY ALL 4605 02:47:08,982 --> 02:47:10,817 TISSUES HAVE SOME MEASURE OF SEX 4606 02:47:10,817 --> 02:47:14,221 BIAS GENE EXPRESSION AND 4607 02:47:14,221 --> 02:47:14,921 REGULATION. 4608 02:47:14,921 --> 02:47:16,356 WE NEED TO UNDERSTAND THAT 4609 02:47:16,356 --> 02:47:17,724 TOGETHER IN AN INTEGRATED 4610 02:47:17,724 --> 02:47:18,858 FASHION, WHAT ARE THE TOXINS, 4611 02:47:18,858 --> 02:47:20,493 WHAT ARE THE ENVIRONMENTAL 4612 02:47:20,493 --> 02:47:22,229 INFLUENCES, WHAT ABOUT THE 4613 02:47:22,229 --> 02:47:23,096 COMORBIDITIES. 4614 02:47:23,096 --> 02:47:24,497 WE NOW HAVE COMPUTATIONAL 4615 02:47:24,497 --> 02:47:25,365 APPROACHES THAT WOULD ALLOW US 4616 02:47:25,365 --> 02:47:29,302 TO TAKE ADVANTAGE OF THIS RANGE 4617 02:47:29,302 --> 02:47:30,503 OF DATA AND CONVERGE ON THE 4618 02:47:30,503 --> 02:47:32,205 HEALTH OF WOMEN AND ASK NEW AND 4619 02:47:32,205 --> 02:47:32,973 DIFFERENT QUESTIONS BECAUSE WE 4620 02:47:32,973 --> 02:47:34,841 HAVE NEW AND BETTER TOOLS TO 4621 02:47:34,841 --> 02:47:37,477 ANSWER THEM. 4622 02:47:37,477 --> 02:47:42,782 IN TERMS OF MENOPAUSAL HORMONE 4623 02:47:42,782 --> 02:47:43,883 THERAPY, AGAIN DR. BRINTON'S 4624 02:47:43,883 --> 02:47:45,218 WORK LOOKED AT COLLECTION OF 4625 02:47:45,218 --> 02:47:47,554 STUDIES AND SHOWED DECREASE IN 4626 02:47:47,554 --> 02:47:48,054 THESE NEURODEGENERATIVE 4627 02:47:48,054 --> 02:47:48,788 DISEASES. 4628 02:47:48,788 --> 02:47:51,191 ON THE TOP THERE, SHE DEVELOPED 4629 02:47:51,191 --> 02:47:53,560 A PHYTOESTROGEN THAT PROMOTES 4630 02:47:53,560 --> 02:47:54,160 ESTROGEN RECEPTOR BETA IN THE 4631 02:47:54,160 --> 02:47:56,396 BRAIN ONLY, BUT HAS INHIBITORY 4632 02:47:56,396 --> 02:47:59,899 EFFECT IN REPRODUCTIVE TISSUES 4633 02:47:59,899 --> 02:48:00,734 AND THE BREAST. 4634 02:48:00,734 --> 02:48:02,269 SHE HAS A SMALL BUSINESS 4635 02:48:02,269 --> 02:48:03,903 INNOVATION GRANT FROM NIH AND 4636 02:48:03,903 --> 02:48:06,306 NIA FUNDING TO DO THIS WORK. 4637 02:48:06,306 --> 02:48:08,041 JUST AN EXAMPLE OF INNOVATION'S 4638 02:48:08,041 --> 02:48:09,242 ROLE IN PUSHING MENOPAUSE AND 4639 02:48:09,242 --> 02:48:10,343 MID LIFE HEALTH OF WOMEN 4640 02:48:10,343 --> 02:48:13,280 THERAPIES TO THE NEXT LEVEL. 4641 02:48:13,280 --> 02:48:16,316 I PROMISED YOU I WOULD TALK 4642 02:48:16,316 --> 02:48:17,083 ABOUT THE EXECUTIVE ORDER. 4643 02:48:17,083 --> 02:48:18,285 HERE I'M GOING TO GIVE YOU A 4644 02:48:18,285 --> 02:48:19,152 COUPLE OF SLIDES ON STEPS THAT 4645 02:48:19,152 --> 02:48:19,786 WE'RE TAKING. 4646 02:48:19,786 --> 02:48:21,221 THERE ARE SEVERAL SECTIONS IN 4647 02:48:21,221 --> 02:48:23,790 THE EO OR EXECUTIVE ORDER. 4648 02:48:23,790 --> 02:48:24,891 ONE IS AROUND FURTHER 4649 02:48:24,891 --> 02:48:26,293 INTEGRATING WOMEN'S HEALTH IN 4650 02:48:26,293 --> 02:48:28,061 THE FEDERAL RESEARCH PROGRAM SO 4651 02:48:28,061 --> 02:48:32,832 BEYOND NIH, OUR PARTNERS AT DOD, 4652 02:48:32,832 --> 02:48:35,802 FOR EXAMPLE, AND WE'RE ENHANCING 4653 02:48:35,802 --> 02:48:36,503 SYSTEM-WIDEN HANSMENTS TO BE 4654 02:48:36,503 --> 02:48:37,504 ABLE TO INCORPORATE 4655 02:48:37,504 --> 02:48:38,471 CONSIDERATIONS OF WOMEN'S HEALTH 4656 02:48:38,471 --> 02:48:40,006 ACROSS THE ENTIRE GRANT LIFE 4657 02:48:40,006 --> 02:48:40,774 LIFECYCLE. 4658 02:48:40,774 --> 02:48:43,043 WE ISSUED A NOTICE OF SPECIAL 4659 02:48:43,043 --> 02:48:44,778 INTEREST, I'LL TALK ABOUT IT IN 4660 02:48:44,778 --> 02:48:48,081 A SECOND, REGARDING GALVANIZING 4661 02:48:48,081 --> 02:48:49,916 RESEARCH IN WOMEN'S MID LIFE 4662 02:48:49,916 --> 02:48:50,150 HEALTH. 4663 02:48:50,150 --> 02:48:52,452 WE ARE ADVANCING THAT THROUGH 4664 02:48:52,452 --> 02:48:53,553 MENOPAUSE COMMON DATA ELEMENTS. 4665 02:48:53,553 --> 02:48:54,921 WE HAVE A WORKING GROUP, WE DID 4666 02:48:54,921 --> 02:48:56,122 A LANDSCAPE ANALYSIS AND WE'RE 4667 02:48:56,122 --> 02:48:57,557 WORKING TO BE ABLE TO HARMONIZE 4668 02:48:57,557 --> 02:48:59,059 DATASETS IN THE FUTURE TO BE 4669 02:48:59,059 --> 02:49:01,461 ABLE TO MAXIMIZE OUR ABILITY TO 4670 02:49:01,461 --> 02:49:02,128 INTERROGATE THEM. 4671 02:49:02,128 --> 02:49:03,430 AND WE'RE PARTICIPATING IN 4672 02:49:03,430 --> 02:49:04,731 ROBUST EFFORTS TO LOOK AT OUR 4673 02:49:04,731 --> 02:49:06,132 FUNDING ACROSS THE FEDERAL 4674 02:49:06,132 --> 02:49:06,566 GOVERNMENT. 4675 02:49:06,566 --> 02:49:08,768 SO HERE ARE A COUPLE OF THE VERY 4676 02:49:08,768 --> 02:49:09,969 PRACTICAL ADVANCES THAT ARE 4677 02:49:09,969 --> 02:49:11,805 AVAILABLE TO YOU RIGHT NOW. 4678 02:49:11,805 --> 02:49:16,076 NOW YOU CAN GO TO THE ORWH 4679 02:49:16,076 --> 02:49:20,280 WEBSITE AND SEE ALL THE NIH 4680 02:49:20,280 --> 02:49:21,181 WOMEN'S SELF FUNDING 4681 02:49:21,181 --> 02:49:22,148 OPPORTUNITIES ACROSS ALL THE 4682 02:49:22,148 --> 02:49:23,683 ICs IN ONE PLACE. 4683 02:49:23,683 --> 02:49:26,920 FOR EXAMPLE YOU'VE GOT 11 OF 4684 02:49:26,920 --> 02:49:29,356 ORWH'S OPPORTUNITIES THAT WE'RE 4685 02:49:29,356 --> 02:49:29,989 LEADING, 112 THAT WERE WITHIN 4686 02:49:29,989 --> 02:49:32,492 THE ICs AND THEN 42 NOTICES OF 4687 02:49:32,492 --> 02:49:33,460 FUNDING OPPORTUNITIES FROM THE 4688 02:49:33,460 --> 02:49:33,793 ICs. 4689 02:49:33,793 --> 02:49:35,328 I WANT TO HIGHLIGHT FOR YOU OUR 4690 02:49:35,328 --> 02:49:36,930 NEWEST FUNDING OPPORTUNITY, 4691 02:49:36,930 --> 02:49:38,365 WHICH IS FOCUSED ON 4692 02:49:38,365 --> 02:49:43,069 UNDERSTANDING CHRONIC CONDITIONS 4693 02:49:43,069 --> 02:49:45,805 UNDERSTUDIED AMONG WOMEN, 4694 02:49:45,805 --> 02:49:47,640 R01 AND R21, SO WE ARE RECEIVING 4695 02:49:47,640 --> 02:49:48,708 APPLICATIONS FOR THAT NEW 4696 02:49:48,708 --> 02:49:49,075 PROGRAM. 4697 02:49:49,075 --> 02:49:53,046 I MENTIONED SBIR/STTR PROGRAM, 4698 02:49:53,046 --> 02:49:55,515 THAT IS MANAGED THROUGH AN 4699 02:49:55,515 --> 02:49:57,817 OMNIBUS OPPORTUNITY THAT'S 4700 02:49:57,817 --> 02:49:58,885 CROSS-GOVERNMENTAL, AND THE 4701 02:49:58,885 --> 02:49:59,686 NEWEST ONE THAT JUST CAME OUT 4702 02:49:59,686 --> 02:50:00,887 THIS YEAR THAT INCLUDES FOR THE 4703 02:50:00,887 --> 02:50:02,255 FIRST TIME SPECIFIC LANGUAGE ON 4704 02:50:02,255 --> 02:50:04,290 WOMEN'S HEALTH AND ORWH HAS 4705 02:50:04,290 --> 02:50:05,291 SIGNED ON FOR THE FIRST TIME. 4706 02:50:05,291 --> 02:50:06,593 YOU MAY REALIZE THIS IS 4707 02:50:06,593 --> 02:50:08,328 MANDATORY SPENDING ACROSS THESE 4708 02:50:08,328 --> 02:50:11,731 AGENCIES. 4709 02:50:11,731 --> 02:50:13,700 IT'S NON-DILUTIVE CAPITAL AND 4710 02:50:13,700 --> 02:50:15,869 IT'S NOT A LOAN SO IT A REALLY 4711 02:50:15,869 --> 02:50:18,138 EXCITING OPPORTUNITY FOR SMALL 4712 02:50:18,138 --> 02:50:20,106 BUSINESSES, FOR INNOVATION AND 4713 02:50:20,106 --> 02:50:22,275 TECH TRANSFER, AND HIGHLIGHTED 4714 02:50:22,275 --> 02:50:23,510 ON THE RIGHT ON THE GRANT LIFE 4715 02:50:23,510 --> 02:50:24,344 SAY KEL, YOU CAN SEE WHERE IT 4716 02:50:24,344 --> 02:50:25,879 CAN REALLY MAKE A DIFFERENCE AT 4717 02:50:25,879 --> 02:50:27,781 THAT PROOF OF CONCEPT AND R & D 4718 02:50:27,781 --> 02:50:28,715 EARLY STAGES. 4719 02:50:28,715 --> 02:50:30,016 SO WE ENCOURAGE YOU TO GET THE 4720 02:50:30,016 --> 02:50:31,117 WORD OUT AND LET PEOPLE KNOW 4721 02:50:31,117 --> 02:50:32,952 THEY SHOULD APPLY FOR THOSE. 4722 02:50:32,952 --> 02:50:34,387 HERE'S THE NIH-WIDE NOTICE OF 4723 02:50:34,387 --> 02:50:35,588 SPECIAL INTEREST I MENTIONED, 4724 02:50:35,588 --> 02:50:37,991 STARTING ON THE LEFT THERE, SO 4725 02:50:37,991 --> 02:50:41,361 THIS NOSI HAS 30 PARTICIPATING 4726 02:50:41,361 --> 02:50:42,896 INSTITUTES AND CENTERS, 4727 02:50:42,896 --> 02:50:44,964 LITERALLY EVERY SINGLE INSTITUTE 4728 02:50:44,964 --> 02:50:46,366 THAT WAS ELIGIBLE SIGNED ON TO 4729 02:50:46,366 --> 02:50:47,700 THIS NOSI. 4730 02:50:47,700 --> 02:50:49,969 THERE ARE 41 DISTINCT 4731 02:50:49,969 --> 02:50:51,404 OPPORTUNITIES IN THESE 4732 02:50:51,404 --> 02:50:53,573 CATEGORIES FROM GRANTS TO Ks 4733 02:50:53,573 --> 02:50:56,176 TO Fs TO SMALL BUSINESS. 4734 02:50:56,176 --> 02:50:58,778 THESE CORRESPOND TO SEVEN 4735 02:50:58,778 --> 02:51:01,848 INVESTIGATOR INITIATED 4736 02:51:01,848 --> 02:51:03,917 OPPORTUNITIES, 15 SOLICITED, 10 4737 02:51:03,917 --> 02:51:05,685 CAREER, FIVE Fs, AND THEN THE 4738 02:51:05,685 --> 02:51:07,821 OMNIBUS THAT I MENTIONED THAT 4739 02:51:07,821 --> 02:51:08,822 CROSSES MULTIPLE AGENCIES AND 4740 02:51:08,822 --> 02:51:10,557 ALL INSTITUTES AND CENTERS AT 4741 02:51:10,557 --> 02:51:10,990 NIH. 4742 02:51:10,990 --> 02:51:13,626 IN THIS NOSI, EVERY INSTITUTE 4743 02:51:13,626 --> 02:51:14,727 ARTICULATED THEIR WOMEN'S HEALTH 4744 02:51:14,727 --> 02:51:15,161 PRIORITIES. 4745 02:51:15,161 --> 02:51:19,332 SO YOU HAVE 175 PRIORITY TOPICS 4746 02:51:19,332 --> 02:51:20,633 IDENTIFIED THAT WE ARE 4747 02:51:20,633 --> 02:51:21,701 INTERESTED IN. 4748 02:51:21,701 --> 02:51:26,639 AND THIS TRANSLATES TO 466 4749 02:51:26,639 --> 02:51:28,174 UNIQUE PATHWAYS FOR WOMEN'S 4750 02:51:28,174 --> 02:51:29,342 HEALTH RESEARCH FUNDING AT NIH 4751 02:51:29,342 --> 02:51:31,978 THAT DID NOT EXIST PRIOR TO THE 4752 02:51:31,978 --> 02:51:32,412 EO. 4753 02:51:32,412 --> 02:51:34,914 WE TOOK THIS ON SERIOUSLY. 4754 02:51:34,914 --> 02:51:36,182 WE'VE PROVIDED PATHWAYS FOR 4755 02:51:36,182 --> 02:51:36,850 FUNDING. 4756 02:51:36,850 --> 02:51:38,184 WE WELCOME APPLICATIONS THAT ARE 4757 02:51:38,184 --> 02:51:41,087 ALOONED ALIGNED WITH OUR MISSIOR 4758 02:51:41,087 --> 02:51:42,088 PRIORITIES ACROSS THOSE 4759 02:51:42,088 --> 02:51:44,691 INSTITUTES AND CENTERS, AND THEY 4760 02:51:44,691 --> 02:51:46,659 RANGE ON TOPICS FROM VIOLENCE TO 4761 02:51:46,659 --> 02:51:51,331 BASIC SCIENCE OF INFECTION, 4762 02:51:51,331 --> 02:51:51,898 POPULATION-LEVEL STUDIES, 4763 02:51:51,898 --> 02:51:53,099 AUTOIMMUNE DISEASE, ENTIRE 4764 02:51:53,099 --> 02:51:55,068 RESEARCH CONTINUUM, MULTIPLE 4765 02:51:55,068 --> 02:51:57,470 MECHANISMS, GRANTS, CONTRACTS 4766 02:51:57,470 --> 02:51:59,739 AND OTHER ARE AVAILABLE TO YOU. 4767 02:51:59,739 --> 02:52:01,140 SO I WANT TO HIGHLIGHT ONE OF 4768 02:52:01,140 --> 02:52:04,944 THE WAYS THAT DR. BERTAGNOLLI, 4769 02:52:04,944 --> 02:52:07,046 OUR NIH DIRECTOR, HAS WORKED ON 4770 02:52:07,046 --> 02:52:08,047 WOMEN'S MID LIFE HEALTH AS ONE 4771 02:52:08,047 --> 02:52:11,518 OF THE FEATURES OF THE ESM O. 4772 02:52:11,518 --> 02:52:11,951 EO. 4773 02:52:11,951 --> 02:52:18,191 AS I MENTIONED TBAFL NIEZING GAG 4774 02:52:18,191 --> 02:52:19,259 RESEARCH ON MID LIFE HEALTH IS 4775 02:52:19,259 --> 02:52:19,893 INCLUDED THERE. 4776 02:52:19,893 --> 02:52:21,561 WE HAVE CREATED A NEW WOMEN'S 4777 02:52:21,561 --> 02:52:22,729 HEALTH ROUNDTABLE TO BRING 4778 02:52:22,729 --> 02:52:23,596 TOGETHER INTERESTED PARTIES AND 4779 02:52:23,596 --> 02:52:24,931 THE FIRST ROUNDTABLE WAS ON MID 4780 02:52:24,931 --> 02:52:25,698 LIFE HEALTH. 4781 02:52:25,698 --> 02:52:26,332 DR. BERTAGNOLLI WAS THERE AND 4782 02:52:26,332 --> 02:52:28,301 SHE PROVIDED REMARKS TO LAUNCH 4783 02:52:28,301 --> 02:52:30,703 THE FIRST EVER PATHWAYS TO 4784 02:52:30,703 --> 02:52:31,938 PREVENTION PROGRAM FOCUSED 4785 02:52:31,938 --> 02:52:33,773 SPECIFICALLY ON MENOPAUSE. 4786 02:52:33,773 --> 02:52:35,074 AND SO WE'RE REALLY THRILLED 4787 02:52:35,074 --> 02:52:36,042 ABOUT THAT. 4788 02:52:36,042 --> 02:52:37,243 THE OFFICE OF DISEASE PREVENTION 4789 02:52:37,243 --> 02:52:40,079 IS THE LEAD, ARC IS A PARTNER 4790 02:52:40,079 --> 02:52:41,614 AND IT A MULTIAGENCY FEDERAL 4791 02:52:41,614 --> 02:52:42,815 EFFORT THAT'S JUST GETTING 4792 02:52:42,815 --> 02:52:43,917 UNDERWAY. 4793 02:52:43,917 --> 02:52:45,652 AND IN ONE OF HER RECENT BLOGS, 4794 02:52:45,652 --> 02:52:48,154 SHE HIGHLIGHTED THE IMPACT OF 4795 02:52:48,154 --> 02:52:49,355 OSTEOPOROSIS, THE NUMBER OF 4796 02:52:49,355 --> 02:52:50,523 PEOPLE AFFECTED AROUND THE 4797 02:52:50,523 --> 02:52:51,491 WORLD, THAT WOMEN ARE MORE 4798 02:52:51,491 --> 02:52:53,259 LIKELY TO BE AFFECTED DUE TO 4799 02:52:53,259 --> 02:52:55,995 DECLINING LEVELS OF ESTROGEN AT 4800 02:52:55,995 --> 02:52:58,831 MENOPAUSE, AND THEN IT CAN HAVE 4801 02:52:58,831 --> 02:52:59,799 RARELY NOTICEABLE SYMPTOMS BUT 4802 02:52:59,799 --> 02:53:02,001 IT CAN HAVE CONSEQUENCES. 4803 02:53:02,001 --> 02:53:06,239 AND SO SHE ALSO INCLUDED 4804 02:53:06,239 --> 02:53:07,907 DR. INGRAHAM'S WORK AND I DID 4805 02:53:07,907 --> 02:53:09,208 NOT KNOW DR. INGRAHAM WAS GOING 4806 02:53:09,208 --> 02:53:12,879 TO BE ON THE AGENDA WHEN I 4807 02:53:12,879 --> 02:53:13,780 PULLED THIS SLIDE WHICH I 4808 02:53:13,780 --> 02:53:14,781 ACTUALLY SHARED WITH 4809 02:53:14,781 --> 02:53:16,182 DR. BERTAGNOLLI ABOUT TWO MONTHS 4810 02:53:16,182 --> 02:53:17,283 AGO ABOUT HER WORK IDENTIFYING 4811 02:53:17,283 --> 02:53:18,785 THIS BRAIN-DERIVED HORMONE 4812 02:53:18,785 --> 02:53:20,453 THAT'S ABLE TO STIMULATE 4813 02:53:20,453 --> 02:53:22,822 SKELETAL STEM CELLS, BUT MY 4814 02:53:22,822 --> 02:53:23,489 UNDERSTANDING, THIS WAS 4815 02:53:23,489 --> 02:53:25,458 IDENTIFIED BECAUSE OF A 4816 02:53:25,458 --> 02:53:26,960 FEMALE-SPECIFIC HUMORAL AGENT 4817 02:53:26,960 --> 02:53:28,161 THAT WAS PRESENT IN LACTATING 4818 02:53:28,161 --> 02:53:30,463 FEMALES THAT SUPPORTS BONE 4819 02:53:30,463 --> 02:53:33,299 DESPITE A REDUCTION IN ESTROGEN 4820 02:53:33,299 --> 02:53:34,000 POSTPARTUM. 4821 02:53:34,000 --> 02:53:36,002 SO TRYING TO CHARACTERIZE WHAT 4822 02:53:36,002 --> 02:53:38,771 WAS HAPPENING IN FEMALE 4823 02:53:38,771 --> 02:53:40,506 LACTATING MICE, THIS BASIC 4824 02:53:40,506 --> 02:53:44,344 SCIENCE LEVEL AND DR. INGRAHAM, 4825 02:53:44,344 --> 02:53:47,513 I TRIE TRIED TO PUT IN ALL YOUR 4826 02:53:47,513 --> 02:53:48,481 ELEGANT EXPERIMENTS, I SAID I'M 4827 02:53:48,481 --> 02:53:49,682 NOT GOING TO BE ABLE TO EXPLAIN 4828 02:53:49,682 --> 02:53:50,650 ALL THESE TRANSPLANTS. 4829 02:53:50,650 --> 02:53:54,053 MAYBE YOU WILL LATER ON, BUT 4830 02:53:54,053 --> 02:53:56,322 INCREDIBLE WORK WITH SHOWING HOW 4831 02:53:56,322 --> 02:53:58,291 ACCOUNTING FOR SEX AS A 4832 02:53:58,291 --> 02:54:00,326 BIOLOGICAL VARIABLE, LOOKING AT 4833 02:54:00,326 --> 02:54:01,794 FEMALE-SPECIFIC FACTORS, LOOKING 4834 02:54:01,794 --> 02:54:04,631 AT WHETHER THE C CN3 WORKS IN 4835 02:54:04,631 --> 02:54:06,265 MALES AND FEMALES, IT DOES, HAS 4836 02:54:06,265 --> 02:54:08,001 IDENTIFIED A POTENTIAL NEW 4837 02:54:08,001 --> 02:54:09,869 THERAPEUTIC TARGET FOR 4838 02:54:09,869 --> 02:54:11,838 OSTEOPOROSIS THAT WOULD BENEFIT 4839 02:54:11,838 --> 02:54:12,705 WOMEN AND MEN. 4840 02:54:12,705 --> 02:54:13,773 WOULD BENEFIT EVERYONE. 4841 02:54:13,773 --> 02:54:17,677 SO WRAPPING UP HERE, MENOPAUSE, 4842 02:54:17,677 --> 02:54:21,648 MORE THAN A MILLION WOMEN, SOME 4843 02:54:21,648 --> 02:54:24,484 DATA SHOW 2 MILLION, MORE THAN 4844 02:54:24,484 --> 02:54:26,019 80% EXPERIENCE VASOMOTOR 4845 02:54:26,019 --> 02:54:27,353 SYMPTOMS OR HOT FLASHES. 4846 02:54:27,353 --> 02:54:29,956 ONLY 15% OF WOMEN RECEIVE 4847 02:54:29,956 --> 02:54:33,760 EVIDENCE-WAST-BASED INTERVENTIOR 4848 02:54:33,760 --> 02:54:34,761 THEIR TREATMENTS. 4849 02:54:34,761 --> 02:54:36,295 ONLY A THIRD, LESS THAN A THIRD 4850 02:54:36,295 --> 02:54:38,364 OF U.S. RESIDENTS REPORT 4851 02:54:38,364 --> 02:54:39,232 RECEIVING MENOPAUSE CURRICULUM 4852 02:54:39,232 --> 02:54:40,233 IN THEIR RESIDENCY. 4853 02:54:40,233 --> 02:54:41,634 I THINK THOSE TWO THERE ARE 4854 02:54:41,634 --> 02:54:41,868 RELATED. 4855 02:54:41,868 --> 02:54:43,302 AND THAT FOLLOWING MENOPAUSE, WE 4856 02:54:43,302 --> 02:54:45,204 KNOW THIS IS THE INFLECTION 4857 02:54:45,204 --> 02:54:46,539 POINT FOR DIAGNOSIS OF CHRONIC 4858 02:54:46,539 --> 02:54:46,806 DISEASES. 4859 02:54:46,806 --> 02:54:50,576 SO WE HAVE AN OPPORTUNITY TO 4860 02:54:50,576 --> 02:54:51,911 INTERVENE, TO PREVENT, TO 4861 02:54:51,911 --> 02:54:52,879 MITIGATE, TO DELAY. 4862 02:54:52,879 --> 02:54:54,180 WE'RE COMMITTED TO IMPROVING THE 4863 02:54:54,180 --> 02:54:56,683 HEALTH OF WOMEN ACROSS THEIR 4864 02:54:56,683 --> 02:54:58,017 LIFECOURSE, AS IS NIH. 4865 02:54:58,017 --> 02:54:59,919 THERE ARE MANY GAPS IN OUR 4866 02:54:59,919 --> 02:55:00,186 KNOWLEDGE. 4867 02:55:00,186 --> 02:55:01,387 WE STILL DON'T KNOW ABOUT WHAT 4868 02:55:01,387 --> 02:55:03,456 ARE THE BEST DIAGNOSTICS THAT 4869 02:55:03,456 --> 02:55:04,657 DELINEATE A MENOPAUSE SYMPTOM 4870 02:55:04,657 --> 02:55:06,592 FROM A CHRONIC DISEASE SYMPTOM. 4871 02:55:06,592 --> 02:55:08,695 WHAT ARE THE BEST BIOMARKERS TO 4872 02:55:08,695 --> 02:55:12,632 TELL US WHERE A WOMAN IS IN THIS 4873 02:55:12,632 --> 02:55:17,203 TRANSITION, DU DO THE SEVERITY F 4874 02:55:17,203 --> 02:55:18,071 SYMPTOMS IDENTIFY WHERE A WOMAN 4875 02:55:18,071 --> 02:55:19,872 IS IN THIS TRANSITION, DO 4876 02:55:19,872 --> 02:55:21,774 SEVERITY OF SYMPTOMS TELL US 4877 02:55:21,774 --> 02:55:24,744 WHERE A WOMAN IS IN THIS 4878 02:55:24,744 --> 02:55:25,845 TRANSITION, WE KNOW THE TIMING 4879 02:55:25,845 --> 02:55:27,680 IS AN ISSUE, WE KNOW THAT THE 4880 02:55:27,680 --> 02:55:29,015 HORMONE FORMULATIONS ARE AN 4881 02:55:29,015 --> 02:55:29,215 ISSUE. 4882 02:55:29,215 --> 02:55:30,717 WE HAVE NEW FORMULATIONS, WE 4883 02:55:30,717 --> 02:55:32,051 NEED TO UNDERSTAND THEM BETTER. 4884 02:55:32,051 --> 02:55:34,454 WE NEED TO UNDERSTAND THE TIME 4885 02:55:34,454 --> 02:55:35,655 THAT WE SHOULD START THOSE 4886 02:55:35,655 --> 02:55:38,224 THERAPIES FOR WHICH WOMEN, AND 4887 02:55:38,224 --> 02:55:39,692 WE DO KNOW, FOR EXAMPLE, THAT 4888 02:55:39,692 --> 02:55:41,027 EARLY ONSET OF MENOPAUSE, 4889 02:55:41,027 --> 02:55:43,863 WHETHER IT'S IATROGENIC OR 4890 02:55:43,863 --> 02:55:45,198 PREMATURE OVARIAN INSUFFICIENCY, 4891 02:55:45,198 --> 02:55:46,265 IS ASSOCIATED WITH INCREASED 4892 02:55:46,265 --> 02:55:48,868 RISK FOR CARDIOVASCULAR DISEASE 4893 02:55:48,868 --> 02:55:49,135 OUTCOMES. 4894 02:55:49,135 --> 02:55:50,069 HOW CAN WE INTERVENE IN THOSE 4895 02:55:50,069 --> 02:55:50,636 WOMEN? 4896 02:55:50,636 --> 02:55:52,939 AND HOW CAN WE EQUITABLY IMPROVE 4897 02:55:52,939 --> 02:55:54,941 EDUCATION AND ACCESS TO CARE, 4898 02:55:54,941 --> 02:55:56,375 EVIDENCE-BASED CARE, FOR ALL 4899 02:55:56,375 --> 02:55:58,111 WOMEN WITH SYMPTOMS OF MENOPAUSE 4900 02:55:58,111 --> 02:56:00,079 WHO DESIRE INTERVENTION. 4901 02:56:00,079 --> 02:56:00,713 SO THOSE ARE SOME OF OUR 4902 02:56:00,713 --> 02:56:01,080 QUESTIONS. 4903 02:56:01,080 --> 02:56:06,753 THIS IS THE MY MENA PLAN WEBPAGE 4904 02:56:06,753 --> 02:56:08,087 WHICH HIGHLIGHT RESEARCH-BASED 4905 02:56:08,087 --> 02:56:10,123 INFORMATION FOR PEOPLE TO 4906 02:56:10,123 --> 02:56:12,091 UNDERSTAND WHAT THERAPIES ARE 4907 02:56:12,091 --> 02:56:13,392 AVAILABLE, AND WE HAVE A WEBPAGE 4908 02:56:13,392 --> 02:56:15,528 ON MENOPAUSE AND MID LIFE HEALTH 4909 02:56:15,528 --> 02:56:16,562 THAT HIGHLIGHTS INFORMATION 4910 02:56:16,562 --> 02:56:18,231 ACROSS NIH, AND I REALLY DO 4911 02:56:18,231 --> 02:56:20,633 BELIEVE THAT MANY WOMEN NEED 4912 02:56:20,633 --> 02:56:22,201 OPTIONS TO MANAGE THEIR 4913 02:56:22,201 --> 02:56:23,369 MENOPAUSE TRANSITION 4914 02:56:23,369 --> 02:56:24,637 SUCCESSFULLY, AND DOING SO WILL 4915 02:56:24,637 --> 02:56:27,039 ALLOW THEM TO ENHANCE THEIR OWN 4916 02:56:27,039 --> 02:56:28,541 HEALTH AND MANY ASPECTS OF THEIR 4917 02:56:28,541 --> 02:56:30,276 LIVES AS WELL AS GAIN FROM FULL 4918 02:56:30,276 --> 02:56:32,245 PARTICIPATION AND BENEFITS WE 4919 02:56:32,245 --> 02:56:34,647 GAIN FROM THEIR FULL 4920 02:56:34,647 --> 02:56:39,585 PARTICIPATION AND BENEFIT FROM 4921 02:56:39,585 --> 02:56:40,653 THEIR BRILLIANCE AND ENERGY. 4922 02:56:40,653 --> 02:56:42,188 SO WE HAVE FULL COURSES ONLINE, 4923 02:56:42,188 --> 02:56:43,689 YOU CAN FOLLOW US ON SOCIAL 4924 02:56:43,689 --> 02:56:44,157 MEDIA HERE. 4925 02:56:44,157 --> 02:56:45,525 I'M ONLY ONE MINUTE OVER, SO 4926 02:56:45,525 --> 02:56:47,193 THANK YOU SO MUCH FOR YOUR 4927 02:56:47,193 --> 02:56:56,269 ATTENTION TODAY. 4928 02:56:56,269 --> 02:56:58,771 >> JANINE, THAT WAS ABSOLUTELY 4929 02:56:58,771 --> 02:56:59,272 SPECTACULAR. 4930 02:56:59,272 --> 02:57:02,141 YOU COVERED IT ALL CLEARLY AND 4931 02:57:02,141 --> 02:57:03,242 TIMING IS PERFECT. 4932 02:57:03,242 --> 02:57:13,753 SO WE HAVE TIME FOR QUESTIONS. 4933 02:57:15,922 --> 02:57:16,489 GO AHEAD. 4934 02:57:16,489 --> 02:57:19,025 >> I REALLY APPRECIATE THIS 4935 02:57:19,025 --> 02:57:22,195 PRESENTATION, AND WONDERING IF 4936 02:57:22,195 --> 02:57:26,866 YOU SEE THE EXECUTIVE ORDER AS A 4937 02:57:26,866 --> 02:57:28,968 VEHICLE FOR INCREASING 4938 02:57:28,968 --> 02:57:30,369 INVESTMENT BY THE OTHER 4939 02:57:30,369 --> 02:57:32,672 INSTITUTES IN WOMEN'S HEALTH, 4940 02:57:32,672 --> 02:57:34,006 YOU KNOW, ON THE ONE HAND, I 4941 02:57:34,006 --> 02:57:37,376 HAVE TO CONGRATULATE THE NIA FOR 4942 02:57:37,376 --> 02:57:38,110 LEADING THE WAY, BUT ON THE 4943 02:57:38,110 --> 02:57:44,050 OTHER HAND, I GET I GUESS A 4944 02:57:44,050 --> 02:57:45,151 LITTLE DISTRESSED THAT THE OTHER 4945 02:57:45,151 --> 02:57:47,220 INSTITUTES ARE LAGGING ON THIS. 4946 02:57:47,220 --> 02:57:51,157 AND I SHOULD HAVE BEGUN WITH AN 4947 02:57:51,157 --> 02:57:55,294 INTRODUCTION -- I'M NANCY 4948 02:57:55,294 --> 02:57:57,430 LUNDEBJERG, AMERICAN GERIATRIC 4949 02:57:57,430 --> 02:57:57,663 SOCIETY. 4950 02:57:57,663 --> 02:57:58,698 >> THANK YOU VERY MUCH FOR THAT 4951 02:57:58,698 --> 02:57:59,131 GREAT QUESTION. 4952 02:57:59,131 --> 02:58:00,666 ACTUALLY WE HAD A PRESENTATION 4953 02:58:00,666 --> 02:58:02,869 THIS MORNING AT THE INSTITUTE 4954 02:58:02,869 --> 02:58:03,636 AND CENTER DIRECTORS MEETING 4955 02:58:03,636 --> 02:58:05,805 WHERE WE LOOKED AT ACROSS NIH, 4956 02:58:05,805 --> 02:58:07,773 THE NUMBER OF FUNDING 4957 02:58:07,773 --> 02:58:10,409 OPPORTUNITIES THAT HAVE -- WE'VE 4958 02:58:10,409 --> 02:58:11,477 RELEASED AS AN AGENCY. 4959 02:58:11,477 --> 02:58:13,012 THEY'VE GONE UP DRAMATICALLY 4960 02:58:13,012 --> 02:58:15,548 FROM 2019 TO 2023, WHICH WAS OUR 4961 02:58:15,548 --> 02:58:16,849 LAST STRATEGIC PLAN. 4962 02:58:16,849 --> 02:58:19,252 I HIGHLIGHTED INFORMATION ON 4963 02:58:19,252 --> 02:58:21,120 MENOPAUSE RESEARCH SPECIFICALLY. 4964 02:58:21,120 --> 02:58:21,888 FOR NIA. 4965 02:58:21,888 --> 02:58:23,189 THE OTHER INSTITUTES ARE 4966 02:58:23,189 --> 02:58:24,523 ADDRESSING WOMEN'S HEALTH 4967 02:58:24,523 --> 02:58:26,692 RESEARCH IN VARIOUS OTHER 4968 02:58:26,692 --> 02:58:26,926 TOPICS. 4969 02:58:26,926 --> 02:58:29,528 AND WE KNOW THAT IT'S NOT JUST 4970 02:58:29,528 --> 02:58:31,197 ABOUT THE NUMBER OF FUNDING 4971 02:58:31,197 --> 02:58:31,898 OPPORTUNITIES. 4972 02:58:31,898 --> 02:58:33,699 IT'S ABOUT THE NATURE OF THE 4973 02:58:33,699 --> 02:58:34,667 OPPORTUNITIES, WHERE THE SCIENCE 4974 02:58:34,667 --> 02:58:36,535 IS GOING, ARE WE PROVIDING 4975 02:58:36,535 --> 02:58:41,107 PATHWAYS FOR FUNDING FOR 4976 02:58:41,107 --> 02:58:42,275 INVESTIGATOR-INITIATED IDEAS, AS 4977 02:58:42,275 --> 02:58:43,609 WELL AS RFAs, THINGS WE WOULD 4978 02:58:43,609 --> 02:58:44,810 LIKE TO SEE, AND I THINK WITH 4979 02:58:44,810 --> 02:58:46,345 THAT NEW NOTICE OF SPECIAL 4980 02:58:46,345 --> 02:58:47,880 INTEREST I HIGHLIGHTED, THERE 4981 02:58:47,880 --> 02:58:51,284 ARE AS MANY PATHWAYS AS POSSIBLE 4982 02:58:51,284 --> 02:58:52,685 FOR ADDRESSING IDEAS. 4983 02:58:52,685 --> 02:58:55,421 EACH OF THE INSTITUTES IS UNIQUE 4984 02:58:55,421 --> 02:58:59,225 IN THEIR WOMEN'S HEALTH SPACE, 4985 02:58:59,225 --> 02:59:00,793 AND IT'S OUR PRIVILEGE TO WORK 4986 02:59:00,793 --> 02:59:02,561 ACROSS THE INTS TEUTS THROUGH 4987 02:59:02,561 --> 02:59:03,162 THE COORDINATING COMMITTEE FOR 4988 02:59:03,162 --> 02:59:04,397 RESEARCH ON WOMEN'S HEALTH AND 4989 02:59:04,397 --> 02:59:08,868 WE ARE NOW EMBARKING ON THE 4990 02:59:08,868 --> 02:59:10,970 EARLY PLANNING STAGES OF 4991 02:59:10,970 --> 02:59:12,271 INTERDISCIPLINARY WOMEN'S HEALTH 4992 02:59:12,271 --> 02:59:13,806 RESEARCH, WHICH WOULD ALLOW FOR 4993 02:59:13,806 --> 02:59:15,441 MORE COLLABORATION ACROSS THE 4994 02:59:15,441 --> 02:59:18,511 INSTITUTES AND CENTERS, LEVERAGE 4995 02:59:18,511 --> 02:59:20,379 THOSE EQUITIES THAT THEY ALREADY 4996 02:59:20,379 --> 02:59:22,548 HAVE, BE EFFECTIVE IN BRINGING 4997 02:59:22,548 --> 02:59:24,183 THEM TOGETHER, BUT ALSO, AND 4998 02:59:24,183 --> 02:59:25,851 IMPORTANTLY, BE MORE EFFECTIVE 4999 02:59:25,851 --> 02:59:29,221 IN ANSWERING INTEGRATIVE 5000 02:59:29,221 --> 02:59:29,889 QUESTIONS THAT ARE HIGHLY 5001 02:59:29,889 --> 02:59:31,090 RELEVANT TO THE WAY WOMEN 5002 02:59:31,090 --> 02:59:31,958 EXPERIENCE HEALTH TODAY. 5003 02:59:31,958 --> 02:59:34,593 SO HOPEFULLY IN A YEAR OR TWO, 5004 02:59:34,593 --> 02:59:36,996 I'LL BE BACK SHOWING YOU SOME 5005 02:59:36,996 --> 02:59:38,297 SCIENTIFIC ADVANCES. 5006 02:59:38,297 --> 02:59:39,832 IN A SHORTER TERM, WE'LL SEE 5007 02:59:39,832 --> 02:59:42,234 SOME NEW WAYS OF DOING RESEARCH 5008 02:59:42,234 --> 02:59:44,103 IN A MORE COLLABORATIVE WAY. 5009 02:59:44,103 --> 02:59:45,304 WE'RE ALREADY DOING THAT. 5010 02:59:45,304 --> 02:59:47,073 BUT I THINK WE CAN TAKE TO THE 5011 02:59:47,073 --> 02:59:48,040 NEXT LEVEL WITH THE NEWER TOOLS 5012 02:59:48,040 --> 02:59:48,908 AND APPROACHES THAT ARE 5013 02:59:48,908 --> 02:59:55,047 AVAILABLE TO US. 5014 02:59:55,047 --> 02:59:56,782 >> IF I CAN JUST ADD, SCIENCE IS 5015 02:59:56,782 --> 02:59:57,750 GOING TO DRIVE US IN THAT 5016 02:59:57,750 --> 03:00:00,186 DIRECTION AS MUCH AS EXECUTIVE 5017 03:00:00,186 --> 03:00:00,586 ORDERS. 5018 03:00:00,586 --> 03:00:03,022 SOME OF THE EXAMPLES WERE CITED, 5019 03:00:03,022 --> 03:00:06,959 AROUND MOTRPAC, BEYOND 5020 03:00:06,959 --> 03:00:08,594 ANTICIPATED DIFFERENCES, SEX 5021 03:00:08,594 --> 03:00:10,463 GENDER DIFFERENCES IN ALMOST 5022 03:00:10,463 --> 03:00:12,531 EVERY VARIABLE, EVERY ORGAN AND 5023 03:00:12,531 --> 03:00:13,299 TISSUE, UNPREDICTABLE DIRECTS 5024 03:00:13,299 --> 03:00:14,934 ARE JUST GOING TO HAVE TO 5025 03:00:14,934 --> 03:00:17,236 STIMULATE NEW AREAS OF RESEARCH, 5026 03:00:17,236 --> 03:00:18,270 IT'S GOING TO AFFECT EVERYONE 5027 03:00:18,270 --> 03:00:20,740 ACROSS ALL OF NIH. 5028 03:00:20,740 --> 03:00:22,041 >> I APPRECIATE THAT. 5029 03:00:22,041 --> 03:00:25,444 I TH THINK HOLLY HAS A QUESTIONT 5030 03:00:25,444 --> 03:00:26,512 RICHARD JUST HIGHLIGHTED THE 5031 03:00:26,512 --> 03:00:28,214 FACT THAT THE RESEARCH BEING 5032 03:00:28,214 --> 03:00:30,850 DONE IN A DIFFERENT WAY APPLYING 5033 03:00:30,850 --> 03:00:33,152 SABV TO THE RESEARCH, BEING MORE 5034 03:00:33,152 --> 03:00:34,253 RIGOROUS HAS MADE IT MORE 5035 03:00:34,253 --> 03:00:35,554 RELEVANT TO THE HEALTH OF WOMEN. 5036 03:00:35,554 --> 03:00:37,189 HAS GIVEN US DATA THAT ALLOWS US 5037 03:00:37,189 --> 03:00:39,925 TO ASK NEW QUESTIONS. 5038 03:00:39,925 --> 03:00:41,560 THAT MAY NOT BE CODED AS WOMEN'S 5039 03:00:41,560 --> 03:00:42,328 HEALTH RESEARCH. 5040 03:00:42,328 --> 03:00:43,429 IT'S RIGOROUS RESEARCH THAT 5041 03:00:43,429 --> 03:00:45,965 LOOKS AT SABV. 5042 03:00:45,965 --> 03:00:47,700 AND SO THAT'S ANOTHER WAY HOW 5043 03:00:47,700 --> 03:00:49,268 THE ENTIRE ENTERPRISE IS DOING 5044 03:00:49,268 --> 03:00:50,236 RESEARCH RELEVANT TO THE HEALTH 5045 03:00:50,236 --> 03:00:53,339 OF WOMEN. 5046 03:00:53,339 --> 03:00:54,807 >> I GUESS I HAD A QUESTION ON 5047 03:00:54,807 --> 03:00:56,509 HOW DO WE PROMOTE OUR WORKFORCE 5048 03:00:56,509 --> 03:00:58,978 SO THAT WE REALLY INCREASE IT SO 5049 03:00:58,978 --> 03:01:00,613 THEY KNOW WHAT THEY'RE DOING 5050 03:01:00,613 --> 03:01:03,449 WITH RESPECT TO NOT ONLY WOMEN'S 5051 03:01:03,449 --> 03:01:05,851 HEALTH BUT SEX DIFFERENCES, AND 5052 03:01:05,851 --> 03:01:07,453 SEX AS A BIOLOGICAL VARIABLE. 5053 03:01:07,453 --> 03:01:10,689 >> HOW DO WE SUPPORT OUR ENTIRE 5054 03:01:10,689 --> 03:01:12,324 BIOMEDICAL RESEARCH WORKFORCE 5055 03:01:12,324 --> 03:01:15,294 RELATED TO BOTH WOMEN'S HEALTH, 5056 03:01:15,294 --> 03:01:19,432 SEX DIFFERENCES, SABV. 5057 03:01:19,432 --> 03:01:20,533 WE COLLABORATE WITH THE FDA ON 5058 03:01:20,533 --> 03:01:21,200 THOSE COURSES. 5059 03:01:21,200 --> 03:01:24,236 WE HAVE AN SABV PRIMER WHICH 5060 03:01:24,236 --> 03:01:25,905 SPECIFICALLY IS ABOUT HOW TO 5061 03:01:25,905 --> 03:01:27,406 APPLY SABV TO YOUR RESEARCH. 5062 03:01:27,406 --> 03:01:29,508 WE HAVE A TRAIN THE TRAINER 5063 03:01:29,508 --> 03:01:30,910 MODULE THAT GOES WITH THAT SO 5064 03:01:30,910 --> 03:01:32,445 THAT IF AN INSTRUCTOR IS NOT 5065 03:01:32,445 --> 03:01:34,413 USED TO TALKING ABOUT SABV, WE 5066 03:01:34,413 --> 03:01:35,815 HAVE A TRAIN THE TRAINER VIDEO 5067 03:01:35,815 --> 03:01:37,583 AS WELL AS THE SABV PRIMER, THEN 5068 03:01:37,583 --> 03:01:39,218 WE HAVE SIX MODULES IN OUR BENCH 5069 03:01:39,218 --> 03:01:41,620 TO BEDSIDE COURSE, WHICH 5070 03:01:41,620 --> 03:01:43,722 HIGHLIGHTS HOW SEX AND GENDER 5071 03:01:43,722 --> 03:01:45,391 AFFECT HEALTH AND DISEASE, FOR 5072 03:01:45,391 --> 03:01:46,592 EXAMPLE, IN NEUROLOGY OR 5073 03:01:46,592 --> 03:01:48,227 IMMUNOLOGY. 5074 03:01:48,227 --> 03:01:49,095 I'M LOOKING FOR TO YOU HELP ME 5075 03:01:49,095 --> 03:01:51,163 GET THE WORD OUT ABOUT THOSE 5076 03:01:51,163 --> 03:01:52,698 TOOLS SO THEY CAN BE UTILIZED. 5077 03:01:52,698 --> 03:01:54,366 RAISING AWARENESS, THE EO 5078 03:01:54,366 --> 03:01:55,935 CERTAINLY HAS RAISED AWARENESS 5079 03:01:55,935 --> 03:01:57,536 ABOUT THE TOPIC, BUT AS RICHARD 5080 03:01:57,536 --> 03:01:59,071 SAID, IT'S THE SCIENCE, IT'S THE 5081 03:01:59,071 --> 03:02:00,873 CLINICAL NEED, IT'S THE VOICES 5082 03:02:00,873 --> 03:02:02,441 OF WOMEN, AND IT'S THE DEMANDS 5083 03:02:02,441 --> 03:02:05,177 OF TODAY AND SOCIETY THAT ARE 5084 03:02:05,177 --> 03:02:06,912 DRIVING WHAT WE NEED TO DO NEXT, 5085 03:02:06,912 --> 03:02:08,481 AND I THINK WE HAVE REALLY THE 5086 03:02:08,481 --> 03:02:10,749 POTENTIAL FOR EXCELLING PROGRESS 5087 03:02:10,749 --> 03:02:14,186 WITH THIS MOMENT. 5088 03:02:14,186 --> 03:02:16,722 >> SHARON, YOU HAVE A QUESTION? 5089 03:02:16,722 --> 03:02:16,956 >> YES. 5090 03:02:16,956 --> 03:02:19,825 THANK YOU, IT WAS JUST AN 5091 03:02:19,825 --> 03:02:21,760 AMAZING, WONDERFUL PRESENTATION, 5092 03:02:21,760 --> 03:02:23,329 AND IT WAS SO GREAT TO HEAR 5093 03:02:23,329 --> 03:02:25,431 ABOUT WHAT'S GOING ON. 5094 03:02:25,431 --> 03:02:29,268 MY QUESTION SPECIFICALLY IS 5095 03:02:29,268 --> 03:02:31,971 REGARDING NOW ON PROGRESS 5096 03:02:31,971 --> 03:02:35,808 REPORTING, MOST PROJECTS ARE 5097 03:02:35,808 --> 03:02:37,243 REQUIRED ON THE RECRUITMENT AND 5098 03:02:37,243 --> 03:02:41,547 ENROLLMENT TABLES TO STRI STRATY 5099 03:02:41,547 --> 03:02:43,916 SEX ON WHO'S ENROLLED AND SO 5100 03:02:43,916 --> 03:02:46,852 FORTH, AND I'M WONDERING IF THAT 5101 03:02:46,852 --> 03:02:49,155 COULD BE EXTENDED EVEN FURTHER 5102 03:02:49,155 --> 03:02:54,059 TO REQUIRE THAT DATA REPORTING 5103 03:02:54,059 --> 03:02:57,463 BE STRATIFIED BY GENDER -- BY 5104 03:02:57,463 --> 03:03:02,201 SEX, I MEAN, IN ALL CASES SUCH 5105 03:03:02,201 --> 03:03:07,206 THAT EVENTUALLY, THIS COULD FORM 5106 03:03:07,206 --> 03:03:08,641 A DATABASE FOR FUTURE RESEARCH. 5107 03:03:08,641 --> 03:03:14,580 I JUST THINK IT'S AN INCREDIBLE 5108 03:03:14,580 --> 03:03:15,614 OPPORTUNITY WHERE NIH COULD LEAD 5109 03:03:15,614 --> 03:03:16,649 THE WAY, AND I'M HOPING THAT 5110 03:03:16,649 --> 03:03:18,717 MIGHT BE CONSIDERED. 5111 03:03:18,717 --> 03:03:20,586 BECAUSE MANY STUDIES ARE 5112 03:03:20,586 --> 03:03:22,321 UNDERPOWERED TO LOOK AT 5113 03:03:22,321 --> 03:03:26,392 SEX-SPECIFIC QUESTIONS, BUT IF 5114 03:03:26,392 --> 03:03:27,826 IT WAS THERE ON EVERY STUDY, 5115 03:03:27,826 --> 03:03:29,461 EVENTUALLY IT COULD JUST BE 5116 03:03:29,461 --> 03:03:29,795 UNPARALLELED. 5117 03:03:29,795 --> 03:03:31,197 SO I JUST WANTED TO RAISE THAT 5118 03:03:31,197 --> 03:03:33,232 AS A QUESTION. 5119 03:03:33,232 --> 03:03:34,400 >> THANK YOU SO MUCH FOR THAT 5120 03:03:34,400 --> 03:03:35,701 QUESTION. 5121 03:03:35,701 --> 03:03:38,137 WL THE SEX AS A BIOLOGICAL 5122 03:03:38,137 --> 03:03:39,905 VARIABLE POLICY, WE REQUEST THAT 5123 03:03:39,905 --> 03:03:42,474 YOU ACCOUNT FOR SABV IN THE 5124 03:03:42,474 --> 03:03:46,045 RESEARCH DESIGN, ANALYSIS AND 5125 03:03:46,045 --> 03:03:48,180 REPORTING OF YOUR WORK AND TO 5126 03:03:48,180 --> 03:03:51,417 JUSTIFY SCIENTIFICALLY 5127 03:03:51,417 --> 03:03:52,384 SINGLE-SEX STUDIES. 5128 03:03:52,384 --> 03:03:54,587 THAT INCLUDES THE PROJECT 5129 03:03:54,587 --> 03:03:54,820 REPORT. 5130 03:03:54,820 --> 03:03:56,455 WE ARE ENCOURAGING INVESTIGATORS 5131 03:03:56,455 --> 03:03:57,656 WHO WE'RE FUNDING WITH PUBLIC 5132 03:03:57,656 --> 03:03:58,757 FUNDING TO PROVIDE THAT KIND OF 5133 03:03:58,757 --> 03:03:59,558 INFORMATION IN THEIR PROGRESS 5134 03:03:59,558 --> 03:03:59,858 REPORTS. 5135 03:03:59,858 --> 03:04:03,329 WE KNOW THAT EACH YEAR YOU MAY 5136 03:04:03,329 --> 03:04:04,396 BE PROGRESSING AT DIFFERENT 5137 03:04:04,396 --> 03:04:05,731 RATES AND DIFFERENT ASPECTS OF 5138 03:04:05,731 --> 03:04:07,566 YOUR GRANTS, BUT WE ALSO 5139 03:04:07,566 --> 03:04:08,667 UNDERSTAND THAT THERE'S A FINAL 5140 03:04:08,667 --> 03:04:11,403 PROGRESS REPORT, AND NOW IN THAT 5141 03:04:11,403 --> 03:04:13,172 PROJECT OUTCOMES SECTION OF THAT 5142 03:04:13,172 --> 03:04:15,908 FINAL RPPR, FOR CLINICAL TRIALS, 5143 03:04:15,908 --> 03:04:18,410 WE NOW REQUEST THAT YOU INCLUDE 5144 03:04:18,410 --> 03:04:21,146 INFORMATION AND SO THE 5145 03:04:21,146 --> 03:04:22,147 INSTRUCTIONS, IT'S A 5146 03:04:22,147 --> 03:04:22,781 CLARIFICATION OF PREVIOUS 5147 03:04:22,781 --> 03:04:23,582 POLICY, INCLUDE INFORMATION ON 5148 03:04:23,582 --> 03:04:26,852 THE PROJECT OUTCOMES IF THERE 5149 03:04:26,852 --> 03:04:28,053 ARE SEX OR GENDER DIFFERENCES 5150 03:04:28,053 --> 03:04:29,188 FOUND FOR CLINICAL TRIALS. 5151 03:04:29,188 --> 03:04:30,889 BUT SHARON, I KNOW THAT YOU'RE 5152 03:04:30,889 --> 03:04:31,790 SPEAKING ABOUT OTHER STUDIES 5153 03:04:31,790 --> 03:04:36,295 WHERE THERE'S AN OPPORTUNITY TO 5154 03:04:36,295 --> 03:04:37,830 HAVE DESCRIPTIVE STATISTICS FOR 5155 03:04:37,830 --> 03:04:42,968 THE PRIMARY OUTCOME FOR BASIC 5156 03:04:42,968 --> 03:04:44,403 SCIENCE STUDIES THAT ARE NOT 5157 03:04:44,403 --> 03:04:45,504 NECESSARILY POWERED TO DETECT 5158 03:04:45,504 --> 03:04:47,373 SEX DIFFERENCES WHICH COULD 5159 03:04:47,373 --> 03:04:49,208 PROVIDE US WITH VARIABILITY DATA 5160 03:04:49,208 --> 03:04:49,842 AND IMPORTANT POTENTIAL SIGNALS 5161 03:04:49,842 --> 03:04:51,877 THAT COULD BE PUT TOGETHER IN 5162 03:04:51,877 --> 03:04:52,745 META-ANALYSES OR OTHER 5163 03:04:52,745 --> 03:04:53,912 APPROACHES THAT WILL ALLOW US TO 5164 03:04:53,912 --> 03:04:54,980 SEE WHERE DO WE NEED TO INVEST 5165 03:04:54,980 --> 03:04:56,148 TO BE ABLE TO FUND STUDIES THAT 5166 03:04:56,148 --> 03:04:59,551 CAN BE POWERED TO LOOK AT 5167 03:04:59,551 --> 03:05:03,155 OUTCOMES IN EITHER SEX OR POWER 5168 03:05:03,155 --> 03:05:04,123 TO LOOK SPECIFICALLY FOR SEX 5169 03:05:04,123 --> 03:05:04,623 DIFFERENCES. 5170 03:05:04,623 --> 03:05:06,859 IF WE DON'T HAVE THAT 5171 03:05:06,859 --> 03:05:09,695 INFORMATION AVAILABLE, WE CAN'T 5172 03:05:09,695 --> 03:05:11,030 GENERATE THOSE -- WE CAN'T 5173 03:05:11,030 --> 03:05:12,865 GENERATE THOSE STUDY DESIGNS. 5174 03:05:12,865 --> 03:05:14,900 AND SO THAT'S A PUBLICATION 5175 03:05:14,900 --> 03:05:15,868 ISSUE AS WELL. 5176 03:05:15,868 --> 03:05:17,069 WE'RE PARTNERING WITH JOURNAL 5177 03:05:17,069 --> 03:05:20,372 EDITORS AND PUBLISHERS ALONG THE 5178 03:05:20,372 --> 03:05:22,207 WAY HERE, AND I WAS SO EXCITED 5179 03:05:22,207 --> 03:05:23,609 TO HEAR THAT THE WORLD HEALTH 5180 03:05:23,609 --> 03:05:25,044 ORGANIZATION RECENTLY ADOPTED 5181 03:05:25,044 --> 03:05:26,478 THE SEX AND GENDER EQUITY IN 5182 03:05:26,478 --> 03:05:30,215 RESEARCH OR SAGER GUIDELINE. 5183 03:05:30,215 --> 03:05:33,519 MANY OTHER JOURNALS, AND NOW THE 5184 03:05:33,519 --> 03:05:34,920 INTERNATIONAL COUNCIL OF MEDICAL 5185 03:05:34,920 --> 03:05:38,090 JOURNAL EDITORS, ICMJE, 5186 03:05:38,090 --> 03:05:40,326 ENCOURAGES THE USE OF SEX AND 5187 03:05:40,326 --> 03:05:41,527 GENDER EQUITY AND RESEARCH 5188 03:05:41,527 --> 03:05:42,127 GUIDELINES. 5189 03:05:42,127 --> 03:05:44,330 SO IT IS AN ECOSYSTEM ISSUE. 5190 03:05:44,330 --> 03:05:45,764 WE'RE ALL WORKING TOGETHER. 5191 03:05:45,764 --> 03:05:46,832 THANK YOU SO MUCH FOR 5192 03:05:46,832 --> 03:05:47,433 HIGHLIGHTING THAT OPPORTUNITY 5193 03:05:47,433 --> 03:05:49,368 FOR US. 5194 03:05:49,368 --> 03:05:51,437 >> RIGHT NOW IT REMAINS 5195 03:05:51,437 --> 03:05:54,606 VOLUNTARY, AND I'M WONDERING IF 5196 03:05:54,606 --> 03:05:56,141 IT -- YOU KNOW, IF IT COULD 5197 03:05:56,141 --> 03:05:58,344 BECOME REQUIRED AS PART OF THE 5198 03:05:58,344 --> 03:06:01,447 FINAL PROGRESS REPORT, BECAUSE 5199 03:06:01,447 --> 03:06:04,583 THERE, YOU KNOW, IF THEY SAY, 5200 03:06:04,583 --> 03:06:05,684 WELL, WE DIDN'T SHOW ANYTHING SO 5201 03:06:05,684 --> 03:06:07,753 WE'RE NOT GOING TO REPORT THAT 5202 03:06:07,753 --> 03:06:10,689 DATA, BUT IF IT'S REQUIRED, EVEN 5203 03:06:10,689 --> 03:06:14,193 IF UNDERPOWERED, EVEN IF THE 5204 03:06:14,193 --> 03:06:16,628 RESULTS GO IN A PERPLEXING 5205 03:06:16,628 --> 03:06:18,097 DIRECTION, THEN EVENTUALLY IF 5206 03:06:18,097 --> 03:06:20,966 YOU HAVE OVER TIME THIS HUGE 5207 03:06:20,966 --> 03:06:24,503 DATABASE FOR META-ANALYSIS, I 5208 03:06:24,503 --> 03:06:26,638 JUST THINK IT WOULD BE SO 5209 03:06:26,638 --> 03:06:26,905 VALUABLE. 5210 03:06:26,905 --> 03:06:28,674 SO YOU KNOW, I ALSO -- I'M IN 5211 03:06:28,674 --> 03:06:30,376 THE PUBLISHING WORLD AS WELL, 5212 03:06:30,376 --> 03:06:33,445 AND WE'RE STRUGGLING WITH THIS 5213 03:06:33,445 --> 03:06:36,081 IN OUR PUBLICATIONS BECAUSE IT 5214 03:06:36,081 --> 03:06:38,050 COMES WITH CONSEQUENCES FOR THAT 5215 03:06:38,050 --> 03:06:41,120 REPORTING, BUT I WAS WONDERING 5216 03:06:41,120 --> 03:06:44,289 IF BECAUSE NIH IS LEADING THE 5217 03:06:44,289 --> 03:06:47,793 WAY ON A VARIETY OF REPORTING BY 5218 03:06:47,793 --> 03:06:50,529 DIVERSITY, AND BY SEX, IT JUST 5219 03:06:50,529 --> 03:06:52,064 SEEMS LIKE SOMETHING WITH 5220 03:06:52,064 --> 03:06:53,832 PLANNING FOR THE FUTURE COULD BE 5221 03:06:53,832 --> 03:06:57,536 AN INCREDIBLE RESOURCE. 5222 03:06:57,536 --> 03:06:58,370 >> THANKS, SHARON. 5223 03:06:58,370 --> 03:07:01,507 I'LL TAKE IT BACK TO THE NIH 5224 03:07:01,507 --> 03:07:02,908 SABV WORKING GROUP THAT 5225 03:07:02,908 --> 03:07:04,243 DR. SHARON HUNTER CO-CHAIRS AND 5226 03:07:04,243 --> 03:07:05,110 WE'LL TALK ABOUT IT AND SEE WHAT 5227 03:07:05,110 --> 03:07:08,514 MIGHT BE POSSIBLE. 5228 03:07:08,514 --> 03:07:09,815 I WANT TO KEEP YOU ON TIME, SO 5229 03:07:09,815 --> 03:07:11,917 THANK YOU SO MUCH FOR INVITING 5230 03:07:11,917 --> 03:07:21,460 ME, DR. HODES AND DR. KELLEY. 5231 03:07:21,460 --> 03:07:24,630 >> JOHN WILL INTRODUCE OUR NEXT 5232 03:07:24,630 --> 03:07:24,863 SPEAKER. 5233 03:07:24,863 --> 03:07:26,465 >> WELL, I'M NOT SURE I NEED TO 5234 03:07:26,465 --> 03:07:29,334 DO ONE NOW. 5235 03:07:29,334 --> 03:07:35,874 THAT WAS A PERFECT SEGUE INTO 5236 03:07:35,874 --> 03:07:37,543 DAB'S RESEARCH HIGHLIGHT SPEAKER 5237 03:07:37,543 --> 03:07:40,712 WHO IS OBVIOUSLY DR. HOLLY 5238 03:07:40,712 --> 03:07:43,582 INGRAHAM, HERZSTEIN ENDOWED 5239 03:07:43,582 --> 03:07:45,217 PROFESSOR IN THE DEPARTMENT OF 5240 03:07:45,217 --> 03:07:46,518 CELLULAR AND MOLECULAR 5241 03:07:46,518 --> 03:07:48,353 PHARMACOLOGY AT UNIVERSITY OF 5242 03:07:48,353 --> 03:07:48,887 CALIFORNIA SAN FRANCISCO, 5243 03:07:48,887 --> 03:07:51,790 RECEIVED HER PH.D. AT UCSD, DID 5244 03:07:51,790 --> 03:07:57,296 A POSTDOC AT SALK. 5245 03:07:57,296 --> 03:07:58,931 FOR THOSE THAT DON'T KNOW HER BY 5246 03:07:58,931 --> 03:08:00,566 NOW, I WOULD BROADLY DESCRIBE 5247 03:08:00,566 --> 03:08:05,270 HER AS A NEUROENDOCRINOLOGIST. 5248 03:08:05,270 --> 03:08:08,340 SHE HAS -- ESPECIALLY SINCE THIS 5249 03:08:08,340 --> 03:08:13,912 RECENT PROJECT HAS BLOWN UP THE 5250 03:08:13,912 --> 03:08:17,349 FIELD, SHE'S SPEAKING A LOT TO 5251 03:08:17,349 --> 03:08:21,587 BOTH NATIONALLY AND 5252 03:08:21,587 --> 03:08:23,555 INTERNATIONALLY, MORE THAN 115 5253 03:08:23,555 --> 03:08:24,957 PUBLICATIONS, VERY INVOLVED IN 5254 03:08:24,957 --> 03:08:28,427 WOMEN'S HEALTH AS YOU JUST 5255 03:08:28,427 --> 03:08:30,262 HEARD, AT MULTIPLE LEVELS, BOTH 5256 03:08:30,262 --> 03:08:31,797 WITHIN HER UNIVERSITY AND 5257 03:08:31,797 --> 03:08:35,634 NATIONALLY. 5258 03:08:35,634 --> 03:08:37,402 AND SO THE FINAL POINT THAT I 5259 03:08:37,402 --> 03:08:41,773 WOULD LIKE TO MAKE IS -- WELL, 5260 03:08:41,773 --> 03:08:43,308 BEYOND THE FACT THAT I COULD 5261 03:08:43,308 --> 03:08:45,077 KEEP GOING ON BUT I WOULD RATHER 5262 03:08:45,077 --> 03:08:51,183 LISTEN TO HER TALK, AND I THINK 5263 03:08:51,183 --> 03:08:55,888 THIS PROJECT IS SUCH A SEMINAL 5264 03:08:55,888 --> 03:08:57,789 OBSERVATION, IT WILL HAVE A 5265 03:08:57,789 --> 03:09:00,959 MASSIVE IMPACT IN THE BONE 5266 03:09:00,959 --> 03:09:03,028 FIELD, BUT THEY HAVE DATA THAT 5267 03:09:03,028 --> 03:09:06,965 SUGGESTS THAT IT WILL REACH 5268 03:09:06,965 --> 03:09:08,600 MULTIPLE ORGAN SYSTEMS. 5269 03:09:08,600 --> 03:09:11,069 AND SO I JUST THINK THIS IS SOME 5270 03:09:11,069 --> 03:09:12,504 OF THE COOLEST DATA I HAVE SEEN 5271 03:09:12,504 --> 03:09:17,242 IN A LONG TIME, AND SO IT'S MY 5272 03:09:17,242 --> 03:09:19,645 PLEASURE TO HAND IT OVER TO 5273 03:09:19,645 --> 03:09:23,715 DR. INGRAHAM. 5274 03:09:23,715 --> 03:09:25,217 >> WELL, THANK YOU. 5275 03:09:25,217 --> 03:09:27,786 I'M GOING TO TELL YOU ABOUT THIS 5276 03:09:27,786 --> 03:09:28,954 STORY. 5277 03:09:28,954 --> 03:09:32,658 I HAVE A FASCINATION IN TERMS OF 5278 03:09:32,658 --> 03:09:33,992 LOOKING AT THE BASIC MECHANISMS 5279 03:09:33,992 --> 03:09:36,295 OF SEX DIFFERENCES, BUT REALLY 5280 03:09:36,295 --> 03:09:37,963 AS THEY RELATE TO UNDERSTANDING 5281 03:09:37,963 --> 03:09:42,100 FEMALE PHYSIOLOGY, AND I WORK 5282 03:09:42,100 --> 03:09:43,602 BOTH IN THE BRAIN AND THE 5283 03:09:43,602 --> 03:09:47,272 GUT-BRAIN CONNECTION TO REALLY 5284 03:09:47,272 --> 03:09:49,007 TRY TO UNRAVEL BASIC MECHANISMS 5285 03:09:49,007 --> 03:09:50,876 THAT MIGHT IMPROVE HUMAN HEALTH. 5286 03:09:50,876 --> 03:09:52,978 AND THIS PROJECT WAS A FIVE-YEAR 5287 03:09:52,978 --> 03:09:55,480 PROJECT, AND I'LL JUST SAY THAT 5288 03:09:55,480 --> 03:09:57,783 I'M GOING TO BOW DOWN TO THE 5289 03:09:57,783 --> 03:09:59,217 NATIONAL INSTITUTE OF AGING 5290 03:09:59,217 --> 03:10:03,155 BECAUSE WITHOUT YOUR SUPPORT, I 5291 03:10:03,155 --> 03:10:04,356 DON'T KNOW THAT THIS WOULD HAVE 5292 03:10:04,356 --> 03:10:05,357 GOTTEN OFF THE GROUND. 5293 03:10:05,357 --> 03:10:10,062 I WAS REJECTED FOUR TIMES FROM 5294 03:10:10,062 --> 03:10:11,129 NIAMS. 5295 03:10:11,129 --> 03:10:14,700 I REMINDED LINDSAY CRISWELL OF 5296 03:10:14,700 --> 03:10:14,967 THAT. 5297 03:10:14,967 --> 03:10:18,070 AND JOHN HAS BEEN AN AMAZING 5298 03:10:18,070 --> 03:10:19,037 PROGRAM OFFICER JUST 5299 03:10:19,037 --> 03:10:20,038 SCIENTIFICALLY AND WHAT A 5300 03:10:20,038 --> 03:10:22,341 CHEERLEADER. 5301 03:10:22,341 --> 03:10:27,613 SO LET ME JUST SAY, JUST 5302 03:10:27,613 --> 03:10:28,947 ITERATING WHAT JANINE HAS 5303 03:10:28,947 --> 03:10:30,215 ALREADY SAID, ONE OF THE 5304 03:10:30,215 --> 03:10:31,883 FASCINATIONS FOR LOOKING AT 5305 03:10:31,883 --> 03:10:34,720 FEMALES IS JUST EVEN AMONG ALL 5306 03:10:34,720 --> 03:10:39,124 SPECIES O, FEMALES LIVE LONGER. 5307 03:10:39,124 --> 03:10:41,093 THESE ARE JUST THE SIX MOST 5308 03:10:41,093 --> 03:10:41,693 PREVALENT DISEASES. 5309 03:10:41,693 --> 03:10:43,495 YOU CAN SEE THAT MALES SUCCUMB 5310 03:10:43,495 --> 03:10:46,264 AND HAVE MORTALITY VERSUS 5311 03:10:46,264 --> 03:10:47,332 FEMALES EXCEPT FOR ALZHEIMER'S 5312 03:10:47,332 --> 03:10:48,333 DISEASE. 5313 03:10:48,333 --> 03:10:53,572 BUT THERE'S THIS PARADOX BECAUSE 5314 03:10:53,572 --> 03:10:54,806 WE LIVE LONGER BUT WE SUFFER 5315 03:10:54,806 --> 03:10:56,108 FROM MORE CHRONIC DISEASES AND 5316 03:10:56,108 --> 03:10:58,510 WE SUFFER WHEN WE HAVE DISEASES, 5317 03:10:58,510 --> 03:11:04,116 THEY'RE MORE SEVERE THAN MEN. 5318 03:11:04,116 --> 03:11:05,117 ESPECIALLY IN THE SKELETAL AND 5319 03:11:05,117 --> 03:11:07,953 JOINT AREA AND THINGS LIKE 5320 03:11:07,953 --> 03:11:09,454 RHEUMATOID ARTHRITIS AND 5321 03:11:09,454 --> 03:11:10,455 OSTEOARTHRITIS. 5322 03:11:10,455 --> 03:11:13,225 SO THOSE AREAS ARE REALLY QUITE 5323 03:11:13,225 --> 03:11:14,960 DIFFERENT FOR FEMALES, AND WE 5324 03:11:14,960 --> 03:11:16,395 REALLY DON'T UNDERSTAND THE 5325 03:11:16,395 --> 03:11:22,000 BASIC MECHANISMS BEHIND THAT. 5326 03:11:22,000 --> 03:11:24,403 SO I LOOK AT THE FEMALE 5327 03:11:24,403 --> 03:11:27,572 LIFECYCLE THROUGH ESTROGEN. 5328 03:11:27,572 --> 03:11:29,241 I THINK ESTROGEN IS REALLY THE 5329 03:11:29,241 --> 03:11:30,008 DRIVING FORCE FOR MOST OF THIS, 5330 03:11:30,008 --> 03:11:32,511 AND IT'S NOT RELATED TO SEX 5331 03:11:32,511 --> 03:11:36,682 CHROMOSOMES, PER SE, BUT REALLY 5332 03:11:36,682 --> 03:11:38,417 THE -- THIS IS REALLY A 5333 03:11:38,417 --> 03:11:39,651 HORMONE-DRIVEN PROCESS, AND 5334 03:11:39,651 --> 03:11:42,788 ESTROGEN IS THE MAIN HORMONE. 5335 03:11:42,788 --> 03:11:45,190 AND SO IF YOU THINK ABOUT THE 5336 03:11:45,190 --> 03:11:47,426 TWO PHASES FOR WOMEN, THERE'S 5337 03:11:47,426 --> 03:11:49,661 THE REPRODUCTIVE AND THE POST 5338 03:11:49,661 --> 03:11:52,831 REPRODUCTIVE PERIOD. 5339 03:11:52,831 --> 03:11:55,434 AND OF COURSE WITH THE 5340 03:11:55,434 --> 03:11:59,905 REPRODUCTIVE PERIOD COMES A HOST 5341 03:11:59,905 --> 03:12:06,178 OF HE FEMALE-SPECIFIC OR FEMALE 5342 03:12:06,178 --> 03:12:07,045 PREVALENT DISEASES. 5343 03:12:07,045 --> 03:12:09,815 THINGS LIKE IRRITABLE BOWEL 5344 03:12:09,815 --> 03:12:12,217 SYNDROME, POLYCYSTIC OVARY 5345 03:12:12,217 --> 03:12:14,553 SYNDROME, ENDOMETRIOSIS, 5346 03:12:14,553 --> 03:12:15,053 PREECLAMPSIA, AFFECTIVE 5347 03:12:15,053 --> 03:12:16,621 DISORDERS THAT ARE REALLY 5348 03:12:16,621 --> 03:12:18,256 PREVALENT RIGHT AROUND PUBERTY 5349 03:12:18,256 --> 03:12:20,892 THAT OCCUR IN FEMALES. 5350 03:12:20,892 --> 03:12:24,963 WE DO NOT UNDERSTAND THE BASIC 5351 03:12:24,963 --> 03:12:25,731 MECHANISMS BEHIND THESE 5352 03:12:25,731 --> 03:12:27,666 DISEASES, AND AS JANINE SAID, 5353 03:12:27,666 --> 03:12:28,633 IT'S NOT CLEAR THAT IF YOU 5354 03:12:28,633 --> 03:12:30,268 SUFFER FROM ENDOMETRIOSIS IN 5355 03:12:30,268 --> 03:12:34,206 THANDTHAT VISCERAL PAIN FOR SO , 5356 03:12:34,206 --> 03:12:34,973 WHAT ARE THE CONSEQUENCES LATER 5357 03:12:34,973 --> 03:12:38,710 ON IN LIFE? 5358 03:12:38,710 --> 03:12:40,112 SO WE REALLY DON'T UNDERSTAND 5359 03:12:40,112 --> 03:12:41,446 THAT. 5360 03:12:41,446 --> 03:12:43,215 I'M WORKING ON IBS AS IT RELATES 5361 03:12:43,215 --> 03:12:45,083 TO VISCERAL PAIN. 5362 03:12:45,083 --> 03:12:47,519 AND THEN AFTER MENOPAUSE, OF 5363 03:12:47,519 --> 03:12:48,520 COURSE, WE'VE HEARD ABOUT 5364 03:12:48,520 --> 03:12:51,690 COGNITIVE DISORDERS, 5365 03:12:51,690 --> 03:12:52,457 OSTEOPOROSIS, CARDIOVASCULAR 5366 03:12:52,457 --> 03:12:54,893 DISEASE, ET CETERA, AND I REMIND 5367 03:12:54,893 --> 03:12:57,295 PEOPLE THAT MENOPAUSE IS NOT 5368 03:12:57,295 --> 03:12:58,697 JUST A CHRONOLOGICAL AGE BUT CAN 5369 03:12:58,697 --> 03:13:00,999 BE PHARMACOLOGICALLY INDUCED IF 5370 03:13:00,999 --> 03:13:02,901 YOU'RE A BREAST CANCER SURVIVOR, 5371 03:13:02,901 --> 03:13:06,404 AND YOU'RE ON ANTI -- YOU'RE ON 5372 03:13:06,404 --> 03:13:09,007 AN AROMATASE INHIBITOR, SO 5373 03:13:09,007 --> 03:13:09,808 ANTIHORMONE THERAPY, YOU ARE 5374 03:13:09,808 --> 03:13:12,210 GOING TO INDUCE MENOPAUSE 5375 03:13:12,210 --> 03:13:14,980 PREMATURELY, AND YOU ARE WITH 5376 03:13:14,980 --> 03:13:16,748 PREMATURE OVARIAN FAILURE, OR IF 5377 03:13:16,748 --> 03:13:18,383 YOU DO ELECTIVE SURGERY AND YOU 5378 03:13:18,383 --> 03:13:20,919 HAVE YOUR OVARIES REMOVED 5379 03:13:20,919 --> 03:13:22,020 BECAUSE YOU'RE FOR INSTANCE A 5380 03:13:22,020 --> 03:13:25,423 BRCA, YOU CONTAIN A BRCA1 OR 5381 03:13:25,423 --> 03:13:26,491 2 MUTATION. 5382 03:13:26,491 --> 03:13:29,828 SO I AM DELIGHTED THAT THIS NEW 5383 03:13:29,828 --> 03:13:31,930 INITIATIVE HAS OCCURRED. 5384 03:13:31,930 --> 03:13:35,534 I'M WAITING TO SEE WHAT THE 5385 03:13:35,534 --> 03:13:36,301 FINANCIAL CONSEQUENCES ARE, 5386 03:13:36,301 --> 03:13:38,737 WAITING TO SEE WHAT NOVEMBER 5387 03:13:38,737 --> 03:13:43,542 BRINGS US, BUT ALSO I AM ON THE 5388 03:13:43,542 --> 03:13:45,777 NA SEMI COMMITTEE TO THE 5389 03:13:45,777 --> 03:13:49,481 NATIONAL ACADEMIES COMMITTEE TO 5390 03:13:49,481 --> 03:13:50,949 ADDRESS THE SCIENTIFIC AND 5391 03:13:50,949 --> 03:13:53,251 FUNDING GAPS IN WOMEN'S HEALTH. 5392 03:13:53,251 --> 03:13:55,554 AND WE ARE FINISHING OUR REPORT. 5393 03:13:55,554 --> 03:13:57,455 IT SHOULD BE OUT IN JANUARY. 5394 03:13:57,455 --> 03:14:01,393 AND IT REALLY DOES HIGHLIGHT 5395 03:14:01,393 --> 03:14:03,361 MANY OF THE THINGS JANINE SAID 5396 03:14:03,361 --> 03:14:04,996 AND THE NEED TO PUT OUR HEADS 5397 03:14:04,996 --> 03:14:05,897 TOGETHER AND REALLY THINK ABOUT 5398 03:14:05,897 --> 03:14:07,766 HOW WE'RE GOING TO ADDRESS 5399 03:14:07,766 --> 03:14:13,772 HEALTH FOR 51% OF AMERICANS. 5400 03:14:13,772 --> 03:14:17,542 AS A BASIC SCIENTIST, I JUST 5401 03:14:17,542 --> 03:14:18,610 STARTED LOOKING AT THIS FROM 5402 03:14:18,610 --> 03:14:18,877 ESTROGEN. 5403 03:14:18,877 --> 03:14:23,448 SO I THINK ABOUT HOW ESTROGEN 5404 03:14:23,448 --> 03:14:23,648 WORKS. 5405 03:14:23,648 --> 03:14:25,250 I USED TO GO TO ALL THE NUCLEAR 5406 03:14:25,250 --> 03:14:28,620 HORMONE MEETINGS AND I WOULD 5407 03:14:28,620 --> 03:14:31,289 LISTEN TO STUDIES ON BREAST 5408 03:14:31,289 --> 03:14:32,490 CANCER, A LOT OF STUDIES ON 5409 03:14:32,490 --> 03:14:34,025 BREAST CANCER, AND I WONDERED 5410 03:14:34,025 --> 03:14:37,462 WHY THESE OTHER AREAS WEREN'T 5411 03:14:37,462 --> 03:14:41,600 BEING DISCUSSED, THINGS LIKE 5412 03:14:41,600 --> 03:14:45,103 ENDOMETRIOSIS, PCOS OR OTHER -- 5413 03:14:45,103 --> 03:14:47,105 JUST OTHER PARTS OF THE BODY 5414 03:14:47,105 --> 03:14:49,774 THAT WERE RECEPTIVE TO ESTROGEN, 5415 03:14:49,774 --> 03:14:50,909 WHY AREN'T THEY ACTUALLY BEING 5416 03:14:50,909 --> 03:14:51,409 ADDRESSED? 5417 03:14:51,409 --> 03:14:52,510 SO YOU CAN LOOK AT THE FUNDING 5418 03:14:52,510 --> 03:14:54,379 LEVELS FOR BREAST CANCER, THIS 5419 03:14:54,379 --> 03:14:57,349 IS ACTIVE FUNDING FOR BREAST 5420 03:14:57,349 --> 03:14:58,116 CANCER, WHEN I JUST GO ON 5421 03:14:58,116 --> 03:14:59,517 REPORTER VERSUS SOME OF THESE 5422 03:14:59,517 --> 03:15:00,452 OTHER THINGS, AND OF COURSE 5423 03:15:00,452 --> 03:15:02,420 BECAUSE OF WHAT JANINE SAID, YOU 5424 03:15:02,420 --> 03:15:03,889 CAN'T REALLY EVEN FIND MENOPAUSE 5425 03:15:03,889 --> 03:15:07,492 BECAUSE THAT JUST CAME UP AS A 5426 03:15:07,492 --> 03:15:08,493 CATEGORY. 5427 03:15:08,493 --> 03:15:12,564 SO THAT IS PROBABLY AT WHAT I 5428 03:15:12,564 --> 03:15:14,199 LIKE TO SAY IS WOMEN'S HEALTH IS 5429 03:15:14,199 --> 03:15:15,834 WAY MORE THAN BREAST CANCER, AND 5430 03:15:15,834 --> 03:15:22,540 WE NEED TO UNDERSTAND THAT. 5431 03:15:22,540 --> 03:15:23,408 SO WE ALSO REALLY NEED TO 5432 03:15:23,408 --> 03:15:24,743 UNDERSTAND THE BASIC MECHANISMS. 5433 03:15:24,743 --> 03:15:29,180 I MEAN, I HAVE SEEN A LOT OF 5434 03:15:29,180 --> 03:15:29,915 EPIDEMIOLOGY STUDIES. 5435 03:15:29,915 --> 03:15:32,617 WE KNOW THERE'S A PROBLEM, WE 5436 03:15:32,617 --> 03:15:34,052 NEED TO UNDERSTAND WHY. 5437 03:15:34,052 --> 03:15:37,055 AND THAT'S WHAT WE DO AS BASIC 5438 03:15:37,055 --> 03:15:39,124 SCIENTISTS. 5439 03:15:39,124 --> 03:15:44,195 SO THE WAW, THE WAY, OF COURSE,M 5440 03:15:44,195 --> 03:15:45,730 LOOKING AT FEMALE PHYSIOLOGY IS 5441 03:15:45,730 --> 03:15:46,932 THROUGH THE LENS OF ESTROGEN. 5442 03:15:46,932 --> 03:15:48,900 AND WE'RE LOOKING IN THE BRAIN, 5443 03:15:48,900 --> 03:15:50,969 AND WE THINK THAT -- WE THINK 5444 03:15:50,969 --> 03:15:53,805 THAT FEMALE PHYSIOLOGY IS REALLY 5445 03:15:53,805 --> 03:15:56,374 POWERED BY ESTROGEN, AND SO I 5446 03:15:56,374 --> 03:15:59,344 WAS ONE OF THE FEW INDIVIDUALS 5447 03:15:59,344 --> 03:16:01,413 THAT SAID I'M GOING TO LOOK AT 5448 03:16:01,413 --> 03:16:04,115 FEMALES, I'M NOT GOING TO SHY 5449 03:16:04,115 --> 03:16:05,917 AWAY FROM THE PEAKS AND VALLEYS 5450 03:16:05,917 --> 03:16:09,220 OF HORMONE FLUCTUATIONS, WHICH 5451 03:16:09,220 --> 03:16:12,691 DROVE TONS OF INVESTIGATORS AWAY 5452 03:16:12,691 --> 03:16:14,159 FROM LOOKING AT FEMALES BECAUSE 5453 03:16:14,159 --> 03:16:17,128 THEY SIMPLY DIDN'T WANT TO DEAL 5454 03:16:17,128 --> 03:16:19,998 WITH THAT VARIATION IN HORMONE 5455 03:16:19,998 --> 03:16:21,066 FLUCTUATIONS. 5456 03:16:21,066 --> 03:16:22,968 SO 15 YEARS AGO, I DECIDED, HEY, 5457 03:16:22,968 --> 03:16:26,671 I'M GOING TO EMBRACE THE 5458 03:16:26,671 --> 03:16:27,439 FLUCTUATIONS AND TRY TO 5459 03:16:27,439 --> 03:16:28,840 UNDERSTAND WHAT THESE 5460 03:16:28,840 --> 03:16:30,308 FLUCTUATIONS MEAN IN TERMS OF 5461 03:16:30,308 --> 03:16:32,577 FEMALE PHYSIOLOGY. 5462 03:16:32,577 --> 03:16:35,347 ASIDE FROM THE BREAST. 5463 03:16:35,347 --> 03:16:35,647 OKAY. 5464 03:16:35,647 --> 03:16:37,115 SO WE LOOK IN THE BRAIN, AND 5465 03:16:37,115 --> 03:16:41,286 WE'RE LOOKING AT THIS AREA, THE 5466 03:16:41,286 --> 03:16:42,587 BASAL MEDIAL HYPOTHALAMUS, WHICH 5467 03:16:42,587 --> 03:16:44,289 IS JUST AT THE BASE OF THE BRAIN 5468 03:16:44,289 --> 03:16:47,425 IN THAT PINK CIRCLE. 5469 03:16:47,425 --> 03:16:48,293 AND ONE OF THE REASONS THAT WE 5470 03:16:48,293 --> 03:16:49,294 LOOK AT THAT PART OF THE BRAIN 5471 03:16:49,294 --> 03:16:52,397 IS BECAUSE THAT IS REALLY THE 5472 03:16:52,397 --> 03:16:54,132 GATEKEEPER FOR MUCH OF OUR 5473 03:16:54,132 --> 03:16:54,632 HOMEOSTASIS. 5474 03:16:54,632 --> 03:16:56,334 SO IF WE THINK ABOUT ENERGY 5475 03:16:56,334 --> 03:17:00,505 BALANCE, INTAKE OF FOOD, SEXUAL 5476 03:17:00,505 --> 03:17:01,506 BEHAVIOR, REPRODUCTIVE 5477 03:17:01,506 --> 03:17:02,507 BEHAVIORS, SLEEP, ET CETERA, 5478 03:17:02,507 --> 03:17:04,609 THIS IS THE REGION OF THE BRAIN 5479 03:17:04,609 --> 03:17:07,545 THAT'S GOING TO CONTROL MOST OF 5480 03:17:07,545 --> 03:17:08,513 THOSE THINGS, AND THIS IS A 5481 03:17:08,513 --> 03:17:09,280 REGION OF THE BRAIN THAT'S GOING 5482 03:17:09,280 --> 03:17:12,517 TO GO OUT AND TALK TO THE 5483 03:17:12,517 --> 03:17:13,985 PERIPHERY AND TAKE SIGNALS UP 5484 03:17:13,985 --> 03:17:16,755 FROM THE PERIPHERY AND THEN SEND 5485 03:17:16,755 --> 03:17:19,090 SIGNALS DOWN TO THE PERIPHERY TO 5486 03:17:19,090 --> 03:17:21,659 MAINTAIN OUR HOMEOSTASIS. 5487 03:17:21,659 --> 03:17:24,095 SO IF WE LOOK AT THE ONE HEAR OF 5488 03:17:24,095 --> 03:17:26,998 THE BRAIN THAT WE'RE LOOKING AT, 5489 03:17:26,998 --> 03:17:29,267 WE ARE LOOKING AT THE AREA OF 5490 03:17:29,267 --> 03:17:30,902 THE BRAIN THAT'S ENRICHED IN 5491 03:17:30,902 --> 03:17:31,569 ESTROGEN RECEPTOR ALPHA. 5492 03:17:31,569 --> 03:17:35,740 THERE ARE THREE ESTROGEN 5493 03:17:35,740 --> 03:17:37,375 RECEPTORS, ER ALPHA OR ESTROGEN 5494 03:17:37,375 --> 03:17:39,010 RECEPTOR ALPHA IS REALLY THE 5495 03:17:39,010 --> 03:17:40,478 DOMINANT RECEPTOR IN THIS BRAIN 5496 03:17:40,478 --> 03:17:42,447 REGION. 5497 03:17:42,447 --> 03:17:47,719 AND I'M SHOWING HERE AN AMINO 5498 03:17:47,719 --> 03:17:48,887 HISTOCHEMISTRY, IT'S LIT UP IN 5499 03:17:48,887 --> 03:17:49,621 PINK. 5500 03:17:49,621 --> 03:17:50,255 YOU CAN SEE THERE'S TWO AREAS 5501 03:17:50,255 --> 03:17:53,291 THAT ARE HIGHLY ENRICHED IN 5502 03:17:53,291 --> 03:18:00,899 THIS -- IN ER ALPHA. 5503 03:18:00,899 --> 03:18:01,766 IT'S NOT IMPORTANT TO KNOW THE 5504 03:18:01,766 --> 03:18:04,369 NAMES, IT'S JUST THERE ARE THESE 5505 03:18:04,369 --> 03:18:05,937 TWO REGIONS THAT ARE HIGHLY 5506 03:18:05,937 --> 03:18:07,272 ENRICHED, AND SO WE STARTED 5507 03:18:07,272 --> 03:18:10,108 LOOKING AT THOSE REGIONS AND 5508 03:18:10,108 --> 03:18:11,443 LOOKING AT THE FUNCTION OF 5509 03:18:11,443 --> 03:18:12,844 ESTROGEN SIGNALING IN THOSE 5510 03:18:12,844 --> 03:18:15,080 REGIONS. 5511 03:18:15,080 --> 03:18:17,582 AND I'LL JUST SUMMARIZE WHAT 5512 03:18:17,582 --> 03:18:19,017 WE'VE FOUND AND THEN TELL YOU 5513 03:18:19,017 --> 03:18:22,720 ABOUT HOW THIS STORY DEVELOPED. 5514 03:18:22,720 --> 03:18:26,591 SO IN ONE AREA, THE VMHVL, WHAT 5515 03:18:26,591 --> 03:18:29,294 WE SHOWED IS THAT THIS -- ABOUT 5516 03:18:29,294 --> 03:18:35,400 200 NEURONS IN THIS REGION ARE 5517 03:18:35,400 --> 03:18:37,936 MOTIVATING SPONTANEOUS ACTIVITY 5518 03:18:37,936 --> 03:18:38,703 RIGHT BEFORE OVULATION. 5519 03:18:38,703 --> 03:18:40,438 WHY DO YOU WANT DO THAT? 5520 03:18:40,438 --> 03:18:41,473 BECAUSE YOU WANT TO RUN AROUND 5521 03:18:41,473 --> 03:18:42,774 AND PROBABLY FIND A MATE SO THAT 5522 03:18:42,774 --> 03:18:45,310 WE CAN HAVE SURVIVAL OF THE 5523 03:18:45,310 --> 03:18:45,877 SPECIES. 5524 03:18:45,877 --> 03:18:49,714 AND SO THIS AREA OF THE BRAIN IS 5525 03:18:49,714 --> 03:18:54,119 REALLY VERY ESTROGEN-RESPONSIVE, 5526 03:18:54,119 --> 03:18:56,321 AND WHAT IT DOES IS IT MOTIVATES 5527 03:18:56,321 --> 03:18:57,021 SPONTANEOUS ACTIVITY. 5528 03:18:57,021 --> 03:18:58,089 WE'RE HOPING TO USE THIS TO 5529 03:18:58,089 --> 03:18:59,057 UNDERSTAND WHAT EXERCISE MIGHT 5530 03:18:59,057 --> 03:19:02,994 BE DOING IN TERMS OF BRAIN 5531 03:19:02,994 --> 03:19:08,066 HEALTH. 5532 03:19:08,066 --> 03:19:09,100 THE OTHER AREA OF THE BRAIN IS 5533 03:19:09,100 --> 03:19:14,172 THE ARCHUIT NUCLEUS. 5534 03:19:14,172 --> 03:19:15,440 THE WAY WE FOUND THIS IS JUST 5535 03:19:15,440 --> 03:19:15,974 PURE LUCK. 5536 03:19:15,974 --> 03:19:20,011 WE WERE USING THIS REGION OF THE 5537 03:19:20,011 --> 03:19:21,112 BRAIN AS A CONTROL REGION FOR 5538 03:19:21,112 --> 03:19:21,913 THE VMH. 5539 03:19:21,913 --> 03:19:25,416 AND WHAT WE FOUND THAT JANINE 5540 03:19:25,416 --> 03:19:27,285 TALKED ABOUT IS THAT THIS -- 5541 03:19:27,285 --> 03:19:31,456 THESE NEURONS IN THIS ONE REGION 5542 03:19:31,456 --> 03:19:32,824 OF THE BRAIN CONTROLLED BONE 5543 03:19:32,824 --> 03:19:33,691 DENSITY. 5544 03:19:33,691 --> 03:19:34,993 AND THIS IS THE PAPER THAT WE'VE 5545 03:19:34,993 --> 03:19:39,831 JUST PUBLISHED, AND WHEN WE 5546 03:19:39,831 --> 03:19:41,766 FIRST SET OUT TO DO THIS, WE 5547 03:19:41,766 --> 03:19:43,968 CALLED THIS BRAIN DERIVED 5548 03:19:43,968 --> 03:19:44,636 OSTEOANABOLIC HORMONE. 5549 03:19:44,636 --> 03:19:49,274 SO IT WAS JUST PURE LUCK THAT WE 5550 03:19:49,274 --> 03:19:51,342 FOUND THIS AND PURE LUCK THAT 5551 03:19:51,342 --> 03:19:53,211 OUR ECHO MRI MEN MINNESOTA WAS 5552 03:19:53,211 --> 03:19:56,281 BROKEN AND WE HAD TO USE DEXA SO 5553 03:19:56,281 --> 03:19:57,515 WE LEARNED ABOUT BONE. 5554 03:19:57,515 --> 03:19:58,783 THIS IS WHERE I'M GOING TO SAY 5555 03:19:58,783 --> 03:20:01,519 AS A BASIC SCIENTIST AND EVEN AS 5556 03:20:01,519 --> 03:20:03,821 A CLINICIAN, WE BECOME SILOED 5557 03:20:03,821 --> 03:20:10,428 INTO OUR OWN AREAS, AND AS A 5558 03:20:10,428 --> 03:20:11,029 NEUROENDOCRINOLOGIST, THE LAST 5559 03:20:11,029 --> 03:20:12,830 THING ON MY MIND WAS BONE, AND 5560 03:20:12,830 --> 03:20:14,299 ANOTHER THING, I DIDN'T KNOW A 5561 03:20:14,299 --> 03:20:16,334 LOT ABOUT BONE. 5562 03:20:16,334 --> 03:20:20,772 SO THIS IS ONE OF THOSE EXAMPLES 5563 03:20:20,772 --> 03:20:24,475 WHERE GETTING OUT OF YOUR RUT 5564 03:20:24,475 --> 03:20:25,443 REALLY CAN MAKE A DIFFERENCE IN 5565 03:20:25,443 --> 03:20:27,145 TERMS OF DISCOVERY. 5566 03:20:27,145 --> 03:20:28,880 SO THE WAY THIS WAS DISCOVERED 5567 03:20:28,880 --> 03:20:31,149 IS STEPHANIE CORREA, NOW 5568 03:20:31,149 --> 03:20:32,650 ASSOCIATE PROFESSOR AT UCLA, 5569 03:20:32,650 --> 03:20:36,054 WENT IN AND SHE STEREO TAS 5570 03:20:36,054 --> 03:20:41,025 PARTICULARLY INJECTED CRE 5571 03:20:41,025 --> 03:20:41,659 RECOMBINASE, IT'S NOT IMPORTANT 5572 03:20:41,659 --> 03:20:42,860 THAT YOU KNOW THAT, BUT 5573 03:20:42,860 --> 03:20:44,062 BASICALLY WE WERE ABLE TO GET 5574 03:20:44,062 --> 03:20:45,630 RID OF ALL THE ESTROGEN 5575 03:20:45,630 --> 03:20:46,497 SIGNALING IN THAT PART OF THE 5576 03:20:46,497 --> 03:20:49,567 BRAIN. 5577 03:20:49,567 --> 03:20:51,436 SHE NOTICED THIS INCREASE IN 5578 03:20:51,436 --> 03:20:53,137 DEXA SO WE SENT IT OFF TO BONE 5579 03:20:53,137 --> 03:20:53,671 PEOPLE. 5580 03:20:53,671 --> 03:20:55,106 AGAIN, I'M NOT A BONE PERSON. 5581 03:20:55,106 --> 03:20:57,609 AND THIS IS A PHENOTYPE THAT WE 5582 03:20:57,609 --> 03:21:06,317 GOT WHEN WE DID THAT ANALYSIS. 5583 03:21:06,317 --> 03:21:07,518 I THOUGHT THAT LOOKS PRETTY 5584 03:21:07,518 --> 03:21:09,053 DENSE TO ME, THE BONE PEOPLE 5585 03:21:09,053 --> 03:21:10,521 CALLED ME UP AND THEY SAID WHAT 5586 03:21:10,521 --> 03:21:11,489 DID YOU DO TO GET THAT DENSE 5587 03:21:11,489 --> 03:21:11,889 BONE? 5588 03:21:11,889 --> 03:21:15,293 SO I HAD TO TELL THEM WHAT WE 5589 03:21:15,293 --> 03:21:16,894 DID, AND SO IT'S NOT ONLY DENSE 5590 03:21:16,894 --> 03:21:20,298 BUT IT'S VERY STRONG. 5591 03:21:20,298 --> 03:21:22,934 SO IF YOU DO A THREE-POINT 5592 03:21:22,934 --> 03:21:25,370 BENDING OR YOU TRY TO CRUSH THE 5593 03:21:25,370 --> 03:21:26,471 VERTEBRAE, IT'S VERY, VERY 5594 03:21:26,471 --> 03:21:28,339 STRONG. 5595 03:21:28,339 --> 03:21:29,440 IT'S NOT ONLY DENSE BUT IT 5596 03:21:29,440 --> 03:21:32,443 STRONG, WHICH IS WHAT YOU WANT. 5597 03:21:32,443 --> 03:21:33,544 AND I'LL JUST SUMMARIZE THE WORK 5598 03:21:33,544 --> 03:21:36,581 THAT WE PUBLISHED IN 2019. 5599 03:21:36,581 --> 03:21:38,349 REMEMBER THIS IS SOMEWHAT 5600 03:21:38,349 --> 03:21:38,916 PARADOXICAL. 5601 03:21:38,916 --> 03:21:40,652 WE'RE GETTING RID OF ESTROGEN 5602 03:21:40,652 --> 03:21:42,086 SIGNALING IN THE BRAIN. 5603 03:21:42,086 --> 03:21:44,389 AND THIS IS ONLY IN FEMALES. 5604 03:21:44,389 --> 03:21:46,858 SO WE ONLY SAW THIS PHENOTYPE IN 5605 03:21:46,858 --> 03:21:47,392 FEMALES. 5606 03:21:47,392 --> 03:21:49,027 HAD WE NOT LOOKED AT FEMALES, WE 5607 03:21:49,027 --> 03:21:51,329 WOULD HAVE NEVER SEEN THIS 5608 03:21:51,329 --> 03:21:52,930 PHENOTYPE. 5609 03:21:52,930 --> 03:21:54,265 AND IMPORTANTLY FOR 5610 03:21:54,265 --> 03:21:56,100 OSTEOPOROSIS, IT'S THE 5611 03:21:56,100 --> 03:21:58,202 TRABECULAR BONE THAT IS 5612 03:21:58,202 --> 03:22:00,238 AFFECTED, WHICH IS THE BONE THAT 5613 03:22:00,238 --> 03:22:04,075 GETS LOST DURING OSTEOPOROSIS OR 5614 03:22:04,075 --> 03:22:07,345 BONE LOSS DURING AGING. 5615 03:22:07,345 --> 03:22:11,115 AND WHAT CANDACE HERBER WHO WAS 5616 03:22:11,115 --> 03:22:13,618 FUNDED BY NIA SHOWED WAS IT'S 5617 03:22:13,618 --> 03:22:16,321 THESE KISS NEWER ONS 5618 03:22:16,321 --> 03:22:19,257 SPECIFICALLY IN THE ARCUATE. 5619 03:22:19,257 --> 03:22:20,625 THERE IS A LOT OF COMPLEXITY IN 5620 03:22:20,625 --> 03:22:22,794 THE BRAIN, AND WE NAILED IT DOWN 5621 03:22:22,794 --> 03:22:25,863 TO THESE ONE SETS OF NEURONS. 5622 03:22:25,863 --> 03:22:29,534 SO WE HAD A -- YOU KNOW, WE HAD 5623 03:22:29,534 --> 03:22:30,301 TO DECIDE, ARE WE GOING TO GO 5624 03:22:30,301 --> 03:22:31,769 AFTER THIS, ARE WE GOING TO 5625 03:22:31,769 --> 03:22:37,608 FIGURE OUT WHY THIS BONE IS 5626 03:22:37,608 --> 03:22:39,277 DENSE AND I SAID YES. 5627 03:22:39,277 --> 03:22:40,111 TRYING TO GET A GRANT WHEN 5628 03:22:40,111 --> 03:22:42,180 YOU'RE NOT A BONE PERSON IS, LET 5629 03:22:42,180 --> 03:22:43,348 ME JUST TELL YOU, THIS IS ONE OF 5630 03:22:43,348 --> 03:22:45,983 THE THINGS ABOUT NIH, IS MOVING 5631 03:22:45,983 --> 03:22:50,588 INTO A NEW FILED FIELD CAN BE E 5632 03:22:50,588 --> 03:22:51,289 CHALLENGING WITH RESPECT TO GET 5633 03:22:51,289 --> 03:22:51,589 FUNDING. 5634 03:22:51,589 --> 03:22:56,427 BUT I WANTED TO KNOW WHAT THIS 5635 03:22:56,427 --> 03:22:58,329 WAS, I FIGURED IF WE FOUND THE 5636 03:22:58,329 --> 03:22:58,963 ANSWER, THIS COULD BE IMPORTANT. 5637 03:22:58,963 --> 03:23:02,166 SO WE STARTED OUT IN 2019 TO ASK 5638 03:23:02,166 --> 03:23:05,002 THAT QUESTION. 5639 03:23:05,002 --> 03:23:07,472 SO WE DID SOMETHING VERY 5640 03:23:07,472 --> 03:23:09,307 OLD-FASHIONED, IT'S PARABIOSIS. 5641 03:23:09,307 --> 03:23:10,641 THIS IS WHERE YOU STITCH MICE 5642 03:23:10,641 --> 03:23:15,713 TOGETHER AND THEN THEIR CIRCLE 5643 03:23:15,713 --> 03:23:16,447 CIRCULATION STARTS JOINING 5644 03:23:16,447 --> 03:23:16,714 TOGETHER. 5645 03:23:16,714 --> 03:23:21,152 THIS WAS USED TO IDENTIFY LEC 5646 03:23:21,152 --> 03:23:23,154 LECTIN, AND IS NOW BEING USED IN 5647 03:23:23,154 --> 03:23:26,824 THE AGING FIELD BY PEOPLE LIKE 5648 03:23:26,824 --> 03:23:30,061 SAUL VALLEJO WHO IS AT UCSF WHO 5649 03:23:30,061 --> 03:23:31,229 HELPED US DO THESE EXPERIMENTS. 5650 03:23:31,229 --> 03:23:32,964 SO I ASSUMED IT HAD TO BE 5651 03:23:32,964 --> 03:23:33,865 HUMORAL RATHER THAN NEURONAL 5652 03:23:33,865 --> 03:23:36,300 BECAUSE I COULDN'T SEE HOW 5653 03:23:36,300 --> 03:23:38,069 NEURONS COULD GET YOU THIS HIGH 5654 03:23:38,069 --> 03:23:41,439 BONE MASS PHENOTYPE. 5655 03:23:41,439 --> 03:23:42,540 SO WE DID THAT. 5656 03:23:42,540 --> 03:23:44,041 WE STITCHED THE CONTROLS 5657 03:23:44,041 --> 03:23:46,310 TOGETHER WITH THE MUTANT, AND 5658 03:23:46,310 --> 03:23:49,580 THEN DID IN VIVO SCANNING, AND 5659 03:23:49,580 --> 03:23:51,949 WHAT WE FOUND IS THAT WHEN YOU 5660 03:23:51,949 --> 03:23:53,217 TAKE A WILD TYPE AND YOU STITCH 5661 03:23:53,217 --> 03:23:54,852 IT WITH ONE OF THESE MUTANT 5662 03:23:54,852 --> 03:23:56,487 FEMALE MICE, THEIR BONE 5663 03:23:56,487 --> 03:23:58,689 INCREASES. 5664 03:23:58,689 --> 03:24:00,792 SO WE KNEW THAT WE PROBABLY HAD 5665 03:24:00,792 --> 03:24:02,560 A CIRCULATING FACTOR THAT WAS 5666 03:24:02,560 --> 03:24:03,995 RESPONSIBLE FOR THIS BONE 5667 03:24:03,995 --> 03:24:07,865 PHENOTYPE. 5668 03:24:07,865 --> 03:24:09,534 THEN WHAT WE DID IS I READ SOME 5669 03:24:09,534 --> 03:24:13,571 BEAUTIFUL PAPERS BY CHUCK CHAN 5670 03:24:13,571 --> 03:24:16,107 AND TOM AMBROSI WHERE THEY HAD 5671 03:24:16,107 --> 03:24:19,010 IDENTIFIED HUMAN AND MOUSE 5672 03:24:19,010 --> 03:24:20,077 SKELETAL STEM CELLS THAT WOULD 5673 03:24:20,077 --> 03:24:22,079 GIVE RISE TO BONE AND CARTILAGE, 5674 03:24:22,079 --> 03:24:25,917 AND I JUST HAVE TO CALL OUT THAT 5675 03:24:25,917 --> 03:24:28,319 CHUCK UNFORTUNATELY SUCCUMBED TO 5676 03:24:28,319 --> 03:24:29,086 LYMPHOMA IN MARCH. 5677 03:24:29,086 --> 03:24:31,255 HE WAS A REALLY BRILLIANT YOUNG 5678 03:24:31,255 --> 03:24:33,658 SCIENTIST. 5679 03:24:33,658 --> 03:24:35,526 TOM IS -- I'M WORKING WITH HIM 5680 03:24:35,526 --> 03:24:37,061 AS A COLLABORATOR. 5681 03:24:37,061 --> 03:24:39,030 HE'S A NEW PROFESSOR AT UC DAVIS 5682 03:24:39,030 --> 03:24:41,132 AND ALSO FUNDED BY NIA. 5683 03:24:41,132 --> 03:24:43,601 SO WHAT THEY -- WHAT WE ASKED 5684 03:24:43,601 --> 03:24:45,803 THEM TO DO WAS NOT ONLY LOOK AT 5685 03:24:45,803 --> 03:24:49,106 THIS BONE THAT WE HAD, THIS HIGH 5686 03:24:49,106 --> 03:24:52,610 BONE MASS PHENOTYPE, WE SHOWED 5687 03:24:52,610 --> 03:24:54,011 THERE'S INCREASED SKELETAL STEM 5688 03:24:54,011 --> 03:24:55,646 CELLS, BUT THEY COULD USE WILD 5689 03:24:55,646 --> 03:24:57,081 TYPE SKELETAL STEM CELLS THAT 5690 03:24:57,081 --> 03:25:01,252 ARE GOING TO BECOME BONE AND 5691 03:25:01,252 --> 03:25:02,153 CARTILAGE, AND THEN WE COULD 5692 03:25:02,153 --> 03:25:05,189 TAKE THOSE AND PUT THOSE IN 5693 03:25:05,189 --> 03:25:07,792 THESE MUTANT MICE AND ASKED DO 5694 03:25:07,792 --> 03:25:08,826 YOU GET MORE BONE IF YOU PUT 5695 03:25:08,826 --> 03:25:09,994 THEM INTO THE KIDNEY? 5696 03:25:09,994 --> 03:25:12,296 BUT THIS IS PROBABLY THE COOLEST 5697 03:25:12,296 --> 03:25:13,397 PAIRMT, MY HUSBAND CALLS IT THE 5698 03:25:13,397 --> 03:25:13,998 BONEHEAD EXPERIMENT. 5699 03:25:13,998 --> 03:25:15,933 YOU TAKE THESE WILD-TYPE 5700 03:25:15,933 --> 03:25:18,002 SKELETAL STEM CELLS AND WE 5701 03:25:18,002 --> 03:25:19,570 ACTUALLY DELIVER THEM INTO THE 5702 03:25:19,570 --> 03:25:23,274 HYPOTHALAMUS AS SHOWN HERE, AND 5703 03:25:23,274 --> 03:25:27,445 THEN YOU WAIT ABOUT SIX WEEKS, 5704 03:25:27,445 --> 03:25:29,514 AND WHAT YOU SEE IF YOU PUT WILD 5705 03:25:29,514 --> 03:25:31,916 TYPE SKELETAL STEM CELLS INTO 5706 03:25:31,916 --> 03:25:35,419 THE MUTANT MOUSE FEMALE, YOU SEE 5707 03:25:35,419 --> 03:25:37,088 THESE OSSICLES FORMING IN THE 5708 03:25:37,088 --> 03:25:37,288 BRAIN. 5709 03:25:37,288 --> 03:25:38,356 HOW COOL IS THAT? 5710 03:25:38,356 --> 03:25:40,992 SO THIS IS A VERY POWERFUL 5711 03:25:40,992 --> 03:25:43,261 FACTOR THAT IS CIRCULATING 5712 03:25:43,261 --> 03:25:46,898 AROUND IN THESE MUTANT MICE. 5713 03:25:46,898 --> 03:25:48,432 SO NOW THIS IS WHERE I'M GOING 5714 03:25:48,432 --> 03:25:51,836 TO SAY WE HIT THE -- THIS WAS 5715 03:25:51,836 --> 03:25:53,571 THE DARK PERIOD. 5716 03:25:53,571 --> 03:25:56,974 ALSO COINCIDED WITH COVID. 5717 03:25:56,974 --> 03:25:58,509 IN PART BECAUSE WE KNEW WE HAD 5718 03:25:58,509 --> 03:26:00,478 SOMETHING, WE HAD A FACTOR, HOW 5719 03:26:00,478 --> 03:26:03,114 ARE WE GOING TO FIND IT? 5720 03:26:03,114 --> 03:26:05,182 THIS IS WHERE, YOU KNOW, ONE HAS 5721 03:26:05,182 --> 03:26:08,586 TO OVERCOME DOGMA, AND ONE HAS 5722 03:26:08,586 --> 03:26:10,254 TO THINK ABOUT ONE'S OWN 5723 03:26:10,254 --> 03:26:12,089 SCIENTIFIC ASSUMPTIONS. 5724 03:26:12,089 --> 03:26:16,227 SO ONE OF THE THING T THINGS THE 5725 03:26:16,227 --> 03:26:17,862 STRUCK WITH IS THIS IS A 5726 03:26:17,862 --> 03:26:18,329 CIRCULATING FACTOR. 5727 03:26:18,329 --> 03:26:19,363 WHAT IS THE IDENTITY? 5728 03:26:19,363 --> 03:26:21,399 IS IT A LIPID, IS IT A PROTEIN, 5729 03:26:21,399 --> 03:26:23,801 IS IT A SMALL MOLECULE 5730 03:26:23,801 --> 03:26:24,969 METABOLITE THAT'S DOING THIS? 5731 03:26:24,969 --> 03:26:26,370 REALLY ENDLESS POSSIBILITIES 5732 03:26:26,370 --> 03:26:27,471 WHEN YOU THINK ABOUT IT. 5733 03:26:27,471 --> 03:26:31,409 AND WHAT IS THE SOURCE? 5734 03:26:31,409 --> 03:26:33,277 IS IT COMING FROM THE BRAIN OR 5735 03:26:33,277 --> 03:26:35,046 IS IT COMING FROM ANOTHER 5736 03:26:35,046 --> 03:26:36,881 TARGET, IS THERE AN INDIRECT 5737 03:26:36,881 --> 03:26:39,450 MECHANISM LIKE THE PITUITARY OR 5738 03:26:39,450 --> 03:26:41,319 THE LIVER, WHICH ARE THE ORGANS 5739 03:26:41,319 --> 03:26:43,154 THAT I THINK ABOUT. 5740 03:26:43,154 --> 03:26:45,356 AND THE OTHER THING THAT WE 5741 03:26:45,356 --> 03:26:47,224 WERE -- I SAID WE'RE JUST GOING 5742 03:26:47,224 --> 03:26:48,893 TO DO SHOTGUN PROTEOMICS, WE'RE 5743 03:26:48,893 --> 03:26:50,227 GOING TO FIND THIS, NO PROBLEM, 5744 03:26:50,227 --> 03:26:51,495 WE'LL BE DONE. 5745 03:26:51,495 --> 03:26:56,067 I TOLD JOHN WE'LL BE DONE. 5746 03:26:56,067 --> 03:26:56,400 NO. 5747 03:26:56,400 --> 03:26:59,337 I CALLED EVERY -- ALMOST EVERY 5748 03:26:59,337 --> 03:27:01,272 MASS SPEC FACILITY I COULD THINK 5749 03:27:01,272 --> 03:27:03,341 ABOUT IN BOSTON AND EVERYWHERE. 5750 03:27:03,341 --> 03:27:05,543 AND THEY SAID NO, THIS IS -- NO, 5751 03:27:05,543 --> 03:27:07,144 NO, IT'S NOT HAPPENING. 5752 03:27:07,144 --> 03:27:08,980 YOU ARE NOT GOING TO FIGURE OUT 5753 03:27:08,980 --> 03:27:10,514 WHAT'S DIFFERENT IN THE MUTANT 5754 03:27:10,514 --> 03:27:13,584 VERSUS THE CONTROL BLOOD. 5755 03:27:13,584 --> 03:27:16,587 AND THAT IS BECAUSE IT REALLY 5756 03:27:16,587 --> 03:27:17,922 DIDN'T DAWN ON ME UNTIL I 5757 03:27:17,922 --> 03:27:20,424 FIGURED WHY -- WHY ARE THEY 5758 03:27:20,424 --> 03:27:21,759 TELLING ME NO? 5759 03:27:21,759 --> 03:27:25,696 IT'S BECAUSE IN THE BLOOD, THE 5760 03:27:25,696 --> 03:27:27,999 RANGE OF ABUNDANCE IN THE BLOOD 5761 03:27:27,999 --> 03:27:28,532 IS JUST HUGE. 5762 03:27:28,532 --> 03:27:29,734 IT GOES FROM THINGS THAT ARE 5763 03:27:29,734 --> 03:27:31,569 VERY, VERY ABUNDANT TO NOT 5764 03:27:31,569 --> 03:27:35,406 ABUNDANT AT ALL, AND MORE 5765 03:27:35,406 --> 03:27:38,943 IMPORTANTLY, 22 PROTEINS MAKE UP 5766 03:27:38,943 --> 03:27:40,011 ABOUT 99% OF THE MASS OF BLOOD. 5767 03:27:40,011 --> 03:27:45,116 SO THAT'S LEAVING 2,000 OF YOUR 5768 03:27:45,116 --> 03:27:46,417 PREDICTED SECRETED PROTEINS TO 5769 03:27:46,417 --> 03:27:47,518 BE THAT 1%. 5770 03:27:47,518 --> 03:27:48,953 SO HOW ARE YOU GOING TO FIND 5771 03:27:48,953 --> 03:27:50,655 THEM WITHOUT A HOOK? 5772 03:27:50,655 --> 03:27:51,856 YOU NEED AN ANTIBODY. 5773 03:27:51,856 --> 03:27:58,262 YOU NEED AN ELISA, AND 5774 03:27:58,262 --> 03:28:00,131 UNFORTUNATELY THE O LINK 5775 03:28:00,131 --> 03:28:01,999 PLATFORMS OR SOME OF THESE NEWER 5776 03:28:01,999 --> 03:28:02,867 PROTEOMIC PLATFORMS ARE NOT 5777 03:28:02,867 --> 03:28:03,768 AVAILABLE FOR MICE. 5778 03:28:03,768 --> 03:28:05,870 BUT IT REALLY DOES SPEAK TO THE 5779 03:28:05,870 --> 03:28:07,204 CHALLENGES OF FINDING A 5780 03:28:07,204 --> 03:28:09,206 BIOMARKER. 5781 03:28:09,206 --> 03:28:10,307 IN BLOOD. 5782 03:28:10,307 --> 03:28:12,610 SO AND THE OTHER PROBLEM THAT I 5783 03:28:12,610 --> 03:28:15,346 HAD IS THAT I THOUGHT -- I WAS 5784 03:28:15,346 --> 03:28:19,016 CONVINCED THIS HAD TO BE A 5785 03:28:19,016 --> 03:28:19,984 NEUROPEPTIDE, WRONG, AND IT HAD 5786 03:28:19,984 --> 03:28:24,055 TO BE COMING FROM THE PITUITARY 5787 03:28:24,055 --> 03:28:32,997 BECAUSE GUILLEMAN IN THE NOBEL 5788 03:28:32,997 --> 03:28:34,331 PRIZE WORK TOLD ME THAT A SOURCE 5789 03:28:34,331 --> 03:28:35,833 HAD TO BE COPPING FROM A SIGNAL 5790 03:28:35,833 --> 03:28:42,239 FROM THE HYPOTHALAMUS HAD TO GO 5791 03:28:42,239 --> 03:28:43,974 DOWN TO THE PITUITARY AND THAT 5792 03:28:43,974 --> 03:28:45,076 WOULD RELEASE THE FACTOR. 5793 03:28:45,076 --> 03:28:48,212 SO THIS HYPOPHYSIOPORTAL SYSTEM 5794 03:28:48,212 --> 03:28:49,714 WAS IN MY MIND AND I THOUGHT IT 5795 03:28:49,714 --> 03:28:50,915 HAD TO BE FROM THE PITUITARY AND 5796 03:28:50,915 --> 03:28:51,482 I WAS WRONG. 5797 03:28:51,482 --> 03:28:52,583 SO THIS IS WHAT IT LOOKED LIKE 5798 03:28:52,583 --> 03:28:53,350 FOR US. 5799 03:28:53,350 --> 03:28:54,952 WE TRIED MANY, MANY THINGS. 5800 03:28:54,952 --> 03:28:56,353 WE TRIED DEVELOPING AN ASSAY. 5801 03:28:56,353 --> 03:28:58,155 I'M TRAINED AS A BIOCHEMIST. 5802 03:28:58,155 --> 03:28:59,290 WE TRIED A LOT OF STUFF. 5803 03:28:59,290 --> 03:29:01,592 AND THAT'S WHAT IT LOOKED LIKE 5804 03:29:01,592 --> 03:29:03,327 TO US FOR A COUPLE OF YEARS, 5805 03:29:03,327 --> 03:29:04,929 EVEN THOUGH I WAS SENDING HIM 5806 03:29:04,929 --> 03:29:09,500 PROGRESS REPORTS, BUT -- AND 5807 03:29:09,500 --> 03:29:13,404 THEN MURIEL BABEY CAME ALONG, 5808 03:29:13,404 --> 03:29:15,406 SHE IS AN ADULT ENDOCRINOLOGIST 5809 03:29:15,406 --> 03:29:16,907 AND SHE SAID, WELL, I THINK I'LL 5810 03:29:16,907 --> 03:29:18,409 PUT THESE MICE ON A HIGH FAT 5811 03:29:18,409 --> 03:29:18,642 DIET. 5812 03:29:18,642 --> 03:29:22,012 I SAID GO AHEAD, IT'S CHEAPER 5813 03:29:22,012 --> 03:29:24,582 THAN SINGLE CELL SEQ. 5814 03:29:24,582 --> 03:29:24,849 SO DO IT. 5815 03:29:24,849 --> 03:29:26,650 AND SHE DID, AND THAT WAS WHEN 5816 03:29:26,650 --> 03:29:27,885 SOME LIGHT OPENED UP IN THIS 5817 03:29:27,885 --> 03:29:28,119 PROJECT. 5818 03:29:28,119 --> 03:29:31,122 AND SO WHEN SHE DID THAT, IT'S 5819 03:29:31,122 --> 03:29:32,323 NOT IMPORTANT FOR YOU TO KNOW 5820 03:29:32,323 --> 03:29:34,391 WHAT THIS MEANS, IT'S JUST 5821 03:29:34,391 --> 03:29:36,227 IMPORTANT FOR YOU TO SEE THE 5822 03:29:36,227 --> 03:29:38,062 DIFFERENCE IN OUR MUTANT MICE, 5823 03:29:38,062 --> 03:29:39,597 WHICH IS OVER ON YOUR RIGHT 5824 03:29:39,597 --> 03:29:41,999 SIDE, YOU CAN SEE WHAT HAPPENS 5825 03:29:41,999 --> 03:29:45,770 ON STANDARD DIET WITH ALL THAT 5826 03:29:45,770 --> 03:29:46,470 LABELING, WHICH MEANS THERE'S A 5827 03:29:46,470 --> 03:29:48,305 LOT OF BONE FORMATION, AND ON A 5828 03:29:48,305 --> 03:29:51,509 HIGH FAT DIET, IT COMPLETELY 5829 03:29:51,509 --> 03:29:51,809 DISAPPEARS. 5830 03:29:51,809 --> 03:29:52,743 THAT'S JUST SHOWN HERE THAT THE 5831 03:29:52,743 --> 03:29:54,812 BONE DISAPPEARS ON A HIGH FAT 5832 03:29:54,812 --> 03:29:55,346 DIET. 5833 03:29:55,346 --> 03:29:58,482 I WAS SURPRISED, BUT I SAID NOW 5834 03:29:58,482 --> 03:30:00,451 WE CAN DO SOMETHING. 5835 03:30:00,451 --> 03:30:04,054 SO WE BEGAN PROFILING ALL THE 5836 03:30:04,054 --> 03:30:05,856 TISSUES THAT I THINK OF, THE 5837 03:30:05,856 --> 03:30:10,127 PITUITARY, THE LIVER, BONE, AND 5838 03:30:10,127 --> 03:30:15,800 FINALLY, THE ARC, THE ARCUATE 5839 03:30:15,800 --> 03:30:16,567 NUCLEUS AND HYPOTHALAMUS, AND 5840 03:30:16,567 --> 03:30:17,902 THAT'S WHERE WE FOUND OUR 5841 03:30:17,902 --> 03:30:18,469 ANSWER. 5842 03:30:18,469 --> 03:30:22,239 SO THIS IS JUST A HEAT MAP HERE 5843 03:30:22,239 --> 03:30:24,608 SHOWING ALL THE GENES THAT ARE 5844 03:30:24,608 --> 03:30:26,811 UP IN RED WITH STANDARD DIET AND 5845 03:30:26,811 --> 03:30:28,179 THE ONES THAT GO DOWN WITH HIGH 5846 03:30:28,179 --> 03:30:28,746 FAT DIET. 5847 03:30:28,746 --> 03:30:29,713 SO THERE'S THIS CLUSTER RIGHT 5848 03:30:29,713 --> 03:30:30,915 HERE. 5849 03:30:30,915 --> 03:30:35,152 AND OF THAT CLUSTER, ONLY TWO 5850 03:30:35,152 --> 03:30:36,887 MET OUR -- WHAT WE CONSIDERED TO 5851 03:30:36,887 --> 03:30:41,358 BE REALLY POTENTIAL CANDIDATES 5852 03:30:41,358 --> 03:30:43,861 BECAUSE THEY CAME ON WHEN THE 5853 03:30:43,861 --> 03:30:44,728 BONE PHENOTYPE CAME ON. 5854 03:30:44,728 --> 03:30:47,898 ONE WAS CCN3 AND THE OTHER WAS 5855 03:30:47,898 --> 03:30:52,336 PRO ENKEF LON, WHICH ENCODES 5856 03:30:52,336 --> 03:30:57,041 NEUROPEPTIDES LIKE MET AND 5857 03:30:57,041 --> 03:30:57,808 KEFLEN AND OTHER THINGS. 5858 03:30:57,808 --> 03:30:59,910 SO IT WAS NOT THE NEUROPEPTIDE 5859 03:30:59,910 --> 03:31:01,145 THAT WENT OUT, IT WAS THIS 5860 03:31:01,145 --> 03:31:02,246 PROTEIN CCN3. 5861 03:31:02,246 --> 03:31:03,914 AND I'LL JUST SHOW THE DATA 5862 03:31:03,914 --> 03:31:05,583 HERE, I MEAN, WE HAVE LOTS OF 5863 03:31:05,583 --> 03:31:09,320 OTHER DATA, BUT IF YOU LOOK AT 5864 03:31:09,320 --> 03:31:11,956 THE -- HERE'S -- THIS IS AN RNA 5865 03:31:11,956 --> 03:31:13,123 SCOPE. 5866 03:31:13,123 --> 03:31:15,860 IT'S LOOKING AT THE TRANSCRIPT 5867 03:31:15,860 --> 03:31:18,128 OF DIFFERENT TRANSCRIPTS IN THE 5868 03:31:18,128 --> 03:31:18,796 ARCUATE NUCLEUS. 5869 03:31:18,796 --> 03:31:22,032 YOU CAN SEE THE ESTROGEN 5870 03:31:22,032 --> 03:31:25,536 RECEPTORS IN BLUE, KISS1 IS IN 5871 03:31:25,536 --> 03:31:29,273 RED, AND WHEN WE KNOCK OUT EER 5872 03:31:29,273 --> 03:31:30,307 ALPHA, SO THERE'S NO BLUE, ALL 5873 03:31:30,307 --> 03:31:33,244 OF A SUDDEN SSN3 COMES ON, AND 5874 03:31:33,244 --> 03:31:34,812 IT COMES ON IN THE RIGHT 5875 03:31:34,812 --> 03:31:36,146 NEURONS. 5876 03:31:36,146 --> 03:31:38,115 SO THAT WAS GREAT, BUT WE NEEDED 5877 03:31:38,115 --> 03:31:39,984 TO SHOW LOSS OF FUNCTION AND 5878 03:31:39,984 --> 03:31:41,085 GAIN OF FUNCTION. 5879 03:31:41,085 --> 03:31:43,120 LET ME JUST TELL YOU WHAT 5880 03:31:43,120 --> 03:31:43,988 CCN3 IS. 5881 03:31:43,988 --> 03:31:45,422 IT'S NOT SUPER IMPORTANT THAT 5882 03:31:45,422 --> 03:31:47,758 YOU KNOW A LOT ABOUT IT, BUT -- 5883 03:31:47,758 --> 03:31:48,525 BECAUSE THERE'S NOT A LOT KNOWN 5884 03:31:48,525 --> 03:31:52,263 ABOUT THESE PROTEINS. 5885 03:31:52,263 --> 03:31:52,796 THERE'S SIX MEMBERS. 5886 03:31:52,796 --> 03:31:55,165 THEY HAD BEEN IMPLICATED IN BONE 5887 03:31:55,165 --> 03:31:59,003 BUT NOT REALLY IN THE RIGHT 5888 03:31:59,003 --> 03:32:00,537 DIRECTION. 5889 03:32:00,537 --> 03:32:01,438 THEIR STRUCTURE LOOKS SOMETHING 5890 03:32:01,438 --> 03:32:02,072 LIKE THIS. 5891 03:32:02,072 --> 03:32:03,307 THEY DON'T KNOW WHAT THE 5892 03:32:03,307 --> 03:32:05,242 RECEPTORS ARE FOR THESE. 5893 03:32:05,242 --> 03:32:07,411 AS I TALK TO SOME OF OUR 5894 03:32:07,411 --> 03:32:10,414 STRUCTURAL BIOLOGISTS AT UCSF, I 5895 03:32:10,414 --> 03:32:11,415 SAID WHY DON'T WE HAVE 5896 03:32:11,415 --> 03:32:12,216 STRUCTURES? 5897 03:32:12,216 --> 03:32:13,217 AND HE SAID BECAUSE NOBODY'S 5898 03:32:13,217 --> 03:32:14,752 GIVEN US A REASON TO GET A 5899 03:32:14,752 --> 03:32:17,821 STRUCTURE. 5900 03:32:17,821 --> 03:32:19,890 SO HOPEFULLY NOW WE'LL GET A 5901 03:32:19,890 --> 03:32:20,324 STRUCTURE. 5902 03:32:20,324 --> 03:32:23,594 SO THIS IS WHAT THE PROTEIN 5903 03:32:23,594 --> 03:32:24,028 LOOKS LIKE. 5904 03:32:24,028 --> 03:32:25,229 AND WE DID THE MOST IMPORTANT 5905 03:32:25,229 --> 03:32:26,430 THING HERE, WHICH IS WE DID A 5906 03:32:26,430 --> 03:32:29,166 GAIN OF FUNCTION EXPERIMENT. 5907 03:32:29,166 --> 03:32:30,467 I'M OLD ENOUGH TO KNOW ALL OF 5908 03:32:30,467 --> 03:32:31,502 THE OTHER MELT DOWNS OF 5909 03:32:31,502 --> 03:32:34,705 DIFFERENT HORMONES IN THE FIELD, 5910 03:32:34,705 --> 03:32:37,341 AND SO WE HAD TO DO OUR DUE 5911 03:32:37,341 --> 03:32:40,344 DILIGENCE OF LOSS OF 5912 03:32:40,344 --> 03:32:41,445 FUNCTION/GAIN OF FUNCTION 5913 03:32:41,445 --> 03:32:41,745 EXPERIMENTS. 5914 03:32:41,745 --> 03:32:44,949 SO HERE WHAT WE'RE DOING IS 5915 03:32:44,949 --> 03:32:48,719 WE'RE EXPRESSING CCN3 IN THE 5916 03:32:48,719 --> 03:32:49,286 LIVER. 5917 03:32:49,286 --> 03:32:51,121 YOUR LIVER SECRETES 60% OF YOUR 5918 03:32:51,121 --> 03:32:51,455 PROTEINS. 5919 03:32:51,455 --> 03:32:53,891 THIS IS A GREAT SORT OF BAG OF 5920 03:32:53,891 --> 03:32:55,359 CELL TO GET PROTEIN SECRETED OUT 5921 03:32:55,359 --> 03:32:56,794 TO THE BLOOD, AND THAT'S WHAT WE 5922 03:32:56,794 --> 03:32:57,261 DID. 5923 03:32:57,261 --> 03:33:00,698 SO WE DID A VIRAL TRANSDUCTION 5924 03:33:00,698 --> 03:33:10,607 TO GET CCN3673 EXPRESSED. 5925 03:33:10,607 --> 03:33:11,141 IT'S SHOWN THERE IN GREEN. 5926 03:33:11,141 --> 03:33:12,676 SO WHEN WE DO THAT, WE GET 5927 03:33:12,676 --> 03:33:14,211 INCREASED BONE VOLUME, INCREASED 5928 03:33:14,211 --> 03:33:16,013 BONE STRENGTH, INCREASED BONE 5929 03:33:16,013 --> 03:33:19,750 FORMATION, ALL IN FIVE WEEKS 5930 03:33:19,750 --> 03:33:20,951 AFTER WE TRANSDUCED THE LIVER. 5931 03:33:20,951 --> 03:33:22,786 SO THIS IS A VERY ROBUST 5932 03:33:22,786 --> 03:33:23,087 RESPONSE. 5933 03:33:23,087 --> 03:33:25,255 THIS JUST SHOWS IN AN AGED MOUSE 5934 03:33:25,255 --> 03:33:26,690 HOW MUCH WE CAN INCREASE THEIR 5935 03:33:26,690 --> 03:33:29,593 BONE MASS BY ABOUT 100%. 5936 03:33:29,593 --> 03:33:32,029 SO IT'S REALLY QUITE -- WE'RE 5937 03:33:32,029 --> 03:33:35,199 ONLY DOING THIS NINE WEEKS AFTER 5938 03:33:35,199 --> 03:33:37,034 WE INFECT IT, SO THIS IS A VERY 5939 03:33:37,034 --> 03:33:40,104 POTENT FACTOR. 5940 03:33:40,104 --> 03:33:41,638 THEN PERHAPS THE MOST 5941 03:33:41,638 --> 03:33:45,976 FASCINATING DATA TO ME, ALL THIS 5942 03:33:45,976 --> 03:33:46,610 OTHER STUFF WAS GREAT. 5943 03:33:46,610 --> 03:33:49,880 I DIDN'T START SLEEPING UNTIL I 5944 03:33:49,880 --> 03:33:50,881 GOT THESE DATA. 5945 03:33:50,881 --> 03:33:52,883 AND THAT'S -- THIS WAS DONE WITH 5946 03:33:52,883 --> 03:33:54,685 TOM AND THE PEOPLE UP AT UC 5947 03:33:54,685 --> 03:33:56,553 DAVIS WHERE THEY LOOK AT 5948 03:33:56,553 --> 03:33:57,755 FRACTURE REPAIR. 5949 03:33:57,755 --> 03:34:01,759 SO THEY'RE TAKING -- THEY'RE 5950 03:34:01,759 --> 03:34:03,060 BREAKING THE BONES, THEY'RE 5951 03:34:03,060 --> 03:34:04,361 PUTTING A PIN IN IT AND THEY'RE 5952 03:34:04,361 --> 03:34:06,063 LOOKING AT THIS REPAIR PROCESS. 5953 03:34:06,063 --> 03:34:07,731 WHEN YOU DO THAT AND YOU PUT 5954 03:34:07,731 --> 03:34:10,901 CCN3 IN A SLOW RELEASE GEL INTO 5955 03:34:10,901 --> 03:34:12,836 THIS FRACTURE REPAIR, YOU CAN 5956 03:34:12,836 --> 03:34:17,641 SEE THAT FRACTURE REPAIR, THESE 5957 03:34:17,641 --> 03:34:19,510 ARE 24 MONTHS OLD MICE FROM NIA, 5958 03:34:19,510 --> 03:34:21,745 MALE MICE, OKAY, SO THIS WORKS 5959 03:34:21,745 --> 03:34:25,049 IN BOTH SEXES AND THIS IS REPAIR 5960 03:34:25,049 --> 03:34:28,318 IN A MALE MOUSE, VERY OLD MALE 5961 03:34:28,318 --> 03:34:28,752 MICE. 5962 03:34:28,752 --> 03:34:31,055 AND THIS ESSENTIALLY REVERSES 5963 03:34:31,055 --> 03:34:35,092 THE AGING REPAIR PROCESS. 5964 03:34:35,092 --> 03:34:36,627 IT LOOKS REALLY LIKE A 2 MONTH 5965 03:34:36,627 --> 03:34:37,494 OLD. 5966 03:34:37,494 --> 03:34:42,499 SO NOW OF COURSE WITH THIS IN 5967 03:34:42,499 --> 03:34:46,770 HAND, WE -- YOU KNOW, CAN THIS 5968 03:34:46,770 --> 03:34:48,472 IMPROVE LOSS OF BONE IN A 5969 03:34:48,472 --> 03:34:52,976 VARIETY OF SITUATIONS, BUT IN 5970 03:34:52,976 --> 03:34:54,411 THINGS LIKE HIP FRACTURE, 5971 03:34:54,411 --> 03:34:55,813 PERHAPS DENTAL IMPLANTS WHEN THE 5972 03:34:55,813 --> 03:34:58,348 BONE DEGRADES. 5973 03:34:58,348 --> 03:35:00,918 SO WE ARE NOW TRYING TO FIGURE 5974 03:35:00,918 --> 03:35:02,586 OUT IF WE CAN DO THAT AND TRYING 5975 03:35:02,586 --> 03:35:05,255 TO FIND THE RECEPTOR FOR THIS. 5976 03:35:05,255 --> 03:35:08,692 AND I GET THESE EMAILS ALMOST 5977 03:35:08,692 --> 03:35:10,861 EVERY WEEK FROM A WOMAN SAYING I 5978 03:35:10,861 --> 03:35:13,263 AM DESPERATE TO BE IN YOUR 5979 03:35:13,263 --> 03:35:16,166 CLINICAL TRIAL. 5980 03:35:16,166 --> 03:35:17,601 AND OF COURSE THAT'S COMING, BUT 5981 03:35:17,601 --> 03:35:19,069 THESE -- I JUST -- THERE'S SO 5982 03:35:19,069 --> 03:35:21,538 MANY WOMEN THAT REALLY NEED AN 5983 03:35:21,538 --> 03:35:24,675 ALTERNATIVE TO INCREASE THEIR 5984 03:35:24,675 --> 03:35:26,877 BONE LOSS AND PREVENT BONE LOSS 5985 03:35:26,877 --> 03:35:28,412 AND INCREASE THEIR BONE MASS SO 5986 03:35:28,412 --> 03:35:30,114 THAT THEY CAN LIVE A HEALTHY 5987 03:35:30,114 --> 03:35:31,982 LIFE. 5988 03:35:31,982 --> 03:35:33,083 OKAY. 5989 03:35:33,083 --> 03:35:37,321 SO THE LAST THING I'LL SAY IS 5990 03:35:37,321 --> 03:35:38,755 THAT WHY IS THIS RELEVANT? 5991 03:35:38,755 --> 03:35:42,059 HOW IS THIS -- WE HAD THIS SORT 5992 03:35:42,059 --> 03:35:45,395 OF FRANKENSTEIN MUTANT MOUSE, 5993 03:35:45,395 --> 03:35:48,565 BUT TH IS THIS REALLY RELEVANT O 5994 03:35:48,565 --> 03:35:49,633 REAL PHYSIOLOGY? 5995 03:35:49,633 --> 03:35:52,569 SO WE GLAN LOO BEGAN LOOKING ATE 5996 03:35:52,569 --> 03:35:56,473 DIFFERENT PHASES OF THE FEMALE 5997 03:35:56,473 --> 03:35:59,343 LIFECYCLE, AND WE'RE CONVINCED 5998 03:35:59,343 --> 03:36:01,211 THAT IF THIS THING WERE 5999 03:36:01,211 --> 03:36:04,648 IMPORTANT, IT WOULD COME ON 6000 03:36:04,648 --> 03:36:07,284 AFTER WEANING, SO AFTER 6001 03:36:07,284 --> 03:36:09,253 LACTATION. 6002 03:36:09,253 --> 03:36:11,555 SO WE JUST LOOKED, BILL KRAUSE 6003 03:36:11,555 --> 03:36:11,989 DID THIS. 6004 03:36:11,989 --> 03:36:14,158 WHAT YOU'RE LOOKING AT IS JUST A 6005 03:36:14,158 --> 03:36:15,659 SEA OF PINK BECAUSE THERE'S NO 6006 03:36:15,659 --> 03:36:17,528 GREEN CCN3 THERE DURING ALL 6007 03:36:17,528 --> 03:36:24,334 THESE PHASES IN THE FEMALE. 6008 03:36:24,334 --> 03:36:26,069 THE STAGES FOR FEMALE INCLUDING 6009 03:36:26,069 --> 03:36:27,171 RIGHT AFTER BIRTH, AND THEN WE 6010 03:36:27,171 --> 03:36:32,943 GET THESE DATA SHOWING THAT CCN. 6011 03:36:32,943 --> 03:36:34,678 SO THIS IS -- I SAY I'VE BEEN 6012 03:36:34,678 --> 03:36:36,213 DOING THIS A LONG TIME, YOU GET 6013 03:36:36,213 --> 03:36:37,481 DATA LIKE THIS ONCE EVERY 10 6014 03:36:37,481 --> 03:36:39,883 YEARS. 6015 03:36:39,883 --> 03:36:41,218 REALLY, THIS IS LIKE ALL OF A 6016 03:36:41,218 --> 03:36:47,524 SUDDEN THIS MADE SENSE TO ME. 6017 03:36:47,524 --> 03:36:48,725 SO JUST TO REALLY BRING HOME THE 6018 03:36:48,725 --> 03:36:51,361 POINT, WE WENT IN AND GOT RID OF 6019 03:36:51,361 --> 03:36:55,933 CCN3 IN THE BRAIN BEFORE MICE 6020 03:36:55,933 --> 03:36:58,769 GOT PREGNANT, THEY GET PREGNANT, 6021 03:36:58,769 --> 03:37:01,305 THEY HAVE NORMAL LITTER SIZE, 6022 03:37:01,305 --> 03:37:03,373 THEY LOSE BONE WHEN YOU GET RID 6023 03:37:03,373 --> 03:37:07,411 OF THIS BRAIN CCN3, AND 6024 03:37:07,411 --> 03:37:10,447 IMPORTANTLY, WHEN YOU PUT THEM 6025 03:37:10,447 --> 03:37:12,082 ON A LOW CALCIUM DIET, THEY CAN 6026 03:37:12,082 --> 03:37:13,517 NO LONGER SUSTAIN THEIR PROGENY. 6027 03:37:13,517 --> 03:37:14,318 OKAY. 6028 03:37:14,318 --> 03:37:17,988 SO LET ME JUST GO THROUGH WHY 6029 03:37:17,988 --> 03:37:20,057 THIS IS OCCURRING IN LACTATION. 6030 03:37:20,057 --> 03:37:25,162 AND WHY IT MIGHT BE IMPORTANT. 6031 03:37:25,162 --> 03:37:27,130 SO DURING LACTATION, YOU ARE 6032 03:37:27,130 --> 03:37:28,298 LOSING BONE. 6033 03:37:28,298 --> 03:37:29,933 RODENTS LOSE UP TO 30% OF THEIR 6034 03:37:29,933 --> 03:37:31,602 BONE DURING LACTATION. 6035 03:37:31,602 --> 03:37:34,004 HUMANS LOSE ABOUT 10%. 6036 03:37:34,004 --> 03:37:35,806 IT IS THE TRABECULAR BONE THAT 6037 03:37:35,806 --> 03:37:36,573 IS TARGETED. 6038 03:37:36,573 --> 03:37:39,943 AND THIS IS ALL OCCURRING WHEN 6039 03:37:39,943 --> 03:37:41,178 ESTROGEN HAS PLUMMETED. 6040 03:37:41,178 --> 03:37:43,213 AND YET, THERE WERE STUDIES FROM 6041 03:37:43,213 --> 03:37:46,950 20 YEARS AGO THAT SHOWED DURING 6042 03:37:46,950 --> 03:37:48,252 LACTATION, THERE'S BONE 6043 03:37:48,252 --> 03:37:49,486 REMODELING AND BONE FORMATION 6044 03:37:49,486 --> 03:37:51,488 GOING ON. 6045 03:37:51,488 --> 03:37:56,093 SO WHAT IS HAPPENING, OR A 6046 03:37:56,093 --> 03:37:59,162 HYPOTHESIS IS THAT YOU RESORB 6047 03:37:59,162 --> 03:38:01,198 BONE BY THIS HORMONE THAT'S MADE 6048 03:38:01,198 --> 03:38:05,269 IN THE MAMMARY GLAND, PTHRP, 6049 03:38:05,269 --> 03:38:07,104 THAT CAUSES BONE RESORPTION, AND 6050 03:38:07,104 --> 03:38:09,273 BECAUSE YOU HAVE NO ESTROGEN, 6051 03:38:09,273 --> 03:38:13,010 YOU CAN'T BUILD THAT UP AGAIN SO 6052 03:38:13,010 --> 03:38:15,512 THE BRAIN TAKES OVER AND BEGINS 6053 03:38:15,512 --> 03:38:17,781 RELEASING CCN3 SO THAT YOU HAVE 6054 03:38:17,781 --> 03:38:18,982 ENOUGH BONE SO THAT YOU CAN 6055 03:38:18,982 --> 03:38:20,851 STRIP IT OFF FOR MILK. 6056 03:38:20,851 --> 03:38:25,055 AND THAT'S REALLY WHY THIS COMES 6057 03:38:25,055 --> 03:38:27,057 ON IN THE FEMALE BRAIN ONLY 6058 03:38:27,057 --> 03:38:28,358 DURING LACTATION. 6059 03:38:28,358 --> 03:38:31,328 WE CANNOT FIND IT IN MALES AT 6060 03:38:31,328 --> 03:38:32,696 ANY POINT AND WE HAVE NOT BEEN 6061 03:38:32,696 --> 03:38:35,565 ABLE TO FIND IT IN FEMALES 6062 03:38:35,565 --> 03:38:36,900 EXCEPT FOR LACTATION. 6063 03:38:36,900 --> 03:38:40,570 SO THIS IS MOTHER NATURE, THIS 6064 03:38:40,570 --> 03:38:42,005 IS EVOLUTION WORKING SO LET'S 6065 03:38:42,005 --> 03:38:43,307 FIGURE OUT HOW TO SOLVE THIS 6066 03:38:43,307 --> 03:38:45,809 PROBLEM SO THAT WE CAN SUSTAIN 6067 03:38:45,809 --> 03:38:47,010 PROGENY. 6068 03:38:47,010 --> 03:38:52,616 SO THAT'S REALLY THE STORY, AND 6069 03:38:52,616 --> 03:38:54,351 WE WOULDN'T HAVE FOUND IT HAD IT 6070 03:38:54,351 --> 03:38:56,720 NOT BEEN FOR NATIO NATIONAL INSE 6071 03:38:56,720 --> 03:38:57,754 OF AGING, WE WOULDN'T HAVE FOUND 6072 03:38:57,754 --> 03:39:00,457 IF WE HAD NOT LOOKED FOR -- IN 6073 03:39:00,457 --> 03:39:00,891 FEMALES. 6074 03:39:00,891 --> 03:39:03,393 SO THOSE ARE MY TWO TAKE-HOME 6075 03:39:03,393 --> 03:39:04,795 MESSAGES TO YOU, THAT IT IS 6076 03:39:04,795 --> 03:39:08,632 REALLY IMPORTANT TO LOOK 6077 03:39:08,632 --> 03:39:11,001 BROADLY, GET OUT OF YOUR RUTS, 6078 03:39:11,001 --> 03:39:12,869 AND LOOK ELSEWHERE. 6079 03:39:12,869 --> 03:39:14,371 THERE'S A LOT OF CONNECTION 6080 03:39:14,371 --> 03:39:16,473 GOING THROUGH THE BRAIN BODY 6081 03:39:16,473 --> 03:39:20,944 THAT WE HAVE NO IDEA ABOUT YET, 6082 03:39:20,944 --> 03:39:22,446 AND I'M THINKING THERE'S MANY 6083 03:39:22,446 --> 03:39:23,647 MORE HORMONES THAT ARE GOING TO 6084 03:39:23,647 --> 03:39:25,415 BE RELEASED FROM NEURONS THAT 6085 03:39:25,415 --> 03:39:27,050 ARE GOING TO DICTATE HOMEOSTASIS 6086 03:39:27,050 --> 03:39:27,918 IN OUR BODY. 6087 03:39:27,918 --> 03:39:30,520 SO I'LL JUST SHOW THE PEOPLE OF 6088 03:39:30,520 --> 03:39:31,288 COURSE THAT DID THIS, I'VE 6089 03:39:31,288 --> 03:39:41,832 ALREADY TALKED ABOUT BILL, MEUR 6090 03:39:42,165 --> 03:39:48,438 MURIAL, ZSOFI, CANDICE WERE THE 6091 03:39:48,438 --> 03:39:50,574 MAIN DRIVERS ALONG WITH TOM AMBR 6092 03:39:50,574 --> 03:39:51,808 OSM SI AND OF COURSE THE 6093 03:39:51,808 --> 03:39:54,411 NATIONAL INSTITUTE OF AGING. 6094 03:39:54,411 --> 03:39:56,046 REALLY SUPPORTED MOST OF THIS 6095 03:39:56,046 --> 03:39:56,246 WORK. 6096 03:39:56,246 --> 03:39:56,780 SO THANK YOU. 6097 03:39:56,780 --> 03:39:58,215 >> THANK YOU FOR SHARING THAT 6098 03:39:58,215 --> 03:39:58,882 FANTASTIC STORY. 6099 03:39:58,882 --> 03:40:06,189 QUESTIONS? 6100 03:40:06,189 --> 03:40:16,266 YES. 6101 03:40:16,967 --> 03:40:18,535 SO NEXT STEP, WHAT ARE YOUR NEXT 6102 03:40:18,535 --> 03:40:19,569 EXPERIMENTS? 6103 03:40:19,569 --> 03:40:25,175 >> WELL, ONE OF THE THINGS IS 6104 03:40:25,175 --> 03:40:27,611 BEING ABLE TO DETECT THIS, SO 6105 03:40:27,611 --> 03:40:30,247 WE'RE PLAYING AROUND WITH, YOU 6106 03:40:30,247 --> 03:40:31,982 KNOW, DIFFERENT CONSTRUCTS, 6107 03:40:31,982 --> 03:40:34,050 FIGURING OUT WHAT'S REQUIRED IN 6108 03:40:34,050 --> 03:40:36,453 THAT CCN3 PROTEIN TO BE ACTIVE, 6109 03:40:36,453 --> 03:40:39,856 WHAT IS THE RECEPTOR. 6110 03:40:39,856 --> 03:40:41,291 THAT'S REALLY -- YOU KNOW, WE 6111 03:40:41,291 --> 03:40:43,860 NEED TO FIND THE RECEPTOR. 6112 03:40:43,860 --> 03:40:46,062 AND PROBABLY FROM A BASIC 6113 03:40:46,062 --> 03:40:47,697 SCIENCE POINT OF VIEW IS, WHY 6114 03:40:47,697 --> 03:40:49,099 DOES THIS THING GET -- HOW DOES 6115 03:40:49,099 --> 03:40:50,867 IT GET TURNED ON DURING 6116 03:40:50,867 --> 03:40:53,804 LACTATION AND IN THOSE NEURONS. 6117 03:40:53,804 --> 03:40:55,105 SO THAT'S -- THAT'S THE NEXT 6118 03:40:55,105 --> 03:40:56,406 STEP. 6119 03:40:56,406 --> 03:41:00,577 AND I'M WORKING WITH A COMPANY, 6120 03:41:00,577 --> 03:41:02,245 FOUNDER ON A COMPANY THAT WE ARE 6121 03:41:02,245 --> 03:41:04,514 GOING TO TRY TO TRANSLATE THIS. 6122 03:41:04,514 --> 03:41:07,150 >> I HAD A QUESTION, IT LOOKED 6123 03:41:07,150 --> 03:41:09,519 LIKE IT WAS ATTACHED TO AN IGF 6124 03:41:09,519 --> 03:41:10,720 BINDING PROTEIN, SO DO YOU THINK 6125 03:41:10,720 --> 03:41:12,789 THERE'S SOME INTERACTION WITH 6126 03:41:12,789 --> 03:41:16,326 GROWTH HORMONE IN -- OR IS IT -- 6127 03:41:16,326 --> 03:41:17,093 DOES IT INTERACT? 6128 03:41:17,093 --> 03:41:19,563 >> YOU KNOW, IT'S FOUR DIFFERENT 6129 03:41:19,563 --> 03:41:20,764 DOMAINS, AND I THINK THAT'S BEEN 6130 03:41:20,764 --> 03:41:22,499 PART OF THE PROBLEM WITH PEOPLE 6131 03:41:22,499 --> 03:41:24,234 LOOKING AT THIS PROTEIN. 6132 03:41:24,234 --> 03:41:25,769 THEY LOOK AT ALL THOSE DIFFERENT 6133 03:41:25,769 --> 03:41:27,604 DOMAINS AND THINK THAT EACH ONE 6134 03:41:27,604 --> 03:41:31,641 OF THEM COMBINE CAN BIND TO A T 6135 03:41:31,641 --> 03:41:32,275 RECEPTOR. 6136 03:41:32,275 --> 03:41:34,177 THAT'S A TWO-DIMENSIONAL VIEW OF 6137 03:41:34,177 --> 03:41:34,911 THE PROTEIN. 6138 03:41:34,911 --> 03:41:36,446 A THREE-DIMENSION UNTIL VIEW MAY 6139 03:41:36,446 --> 03:41:42,986 SAY THAT IT GETS FOLDED, IT HAS 6140 03:41:42,986 --> 03:41:44,421 THESE IMMUNOGLOBULIN DOMAINS AND 6141 03:41:44,421 --> 03:41:46,556 PROBABLY BINDS A DISCRETE SET OF 6142 03:41:46,556 --> 03:41:46,990 RECEPTORS. 6143 03:41:46,990 --> 03:41:47,691 SO THAT'S OUR THINKING RIGHT 6144 03:41:47,691 --> 03:41:51,862 NOW. 6145 03:41:51,862 --> 03:41:53,697 >> SO YOU HAD SAID IT ONLY COMES 6146 03:41:53,697 --> 03:41:54,965 ON DURING LACTATION. 6147 03:41:54,965 --> 03:41:58,735 HAVE YOU EVER TRIED IN ANY MODEL 6148 03:41:58,735 --> 03:42:00,804 SYSTEM TO EITHER KNOCK IT DOWN 6149 03:42:00,804 --> 03:42:04,474 OR OVEREXPRESS IT IN AN OLDER 6150 03:42:04,474 --> 03:42:06,910 TYPE OF A MODEL WHERE YOU MIGHT 6151 03:42:06,910 --> 03:42:08,445 HAVE OSTEOARTHRITIS MODEL OR 6152 03:42:08,445 --> 03:42:10,881 SOME KIND OF BONE ROW SORPTION 6153 03:42:10,881 --> 03:42:14,417 RESORPTIONMODEL TO SEE IF YOU CE 6154 03:42:14,417 --> 03:42:15,085 IT? 6155 03:42:15,085 --> 03:42:17,120 AND THAT WOULD SORT OF BE A 6156 03:42:17,120 --> 03:42:18,088 TRANSLATIONAL BRIDGE TOWARDS -- 6157 03:42:18,088 --> 03:42:19,756 >> NO, I DIDN'T MAKE THAT CLEAR, 6158 03:42:19,756 --> 03:42:22,692 SO WE HAVE DONE THAT IN MICE 6159 03:42:22,692 --> 03:42:26,730 WHERE WE'VE TA TAKEN OUT THEIR 6160 03:42:26,730 --> 03:42:28,598 OVARIES AND YOUR BONE REALLY 6161 03:42:28,598 --> 03:42:30,100 DEGRADES THEN, OR THOSE OLDER 6162 03:42:30,100 --> 03:42:30,867 FEMALES AS WELL. 6163 03:42:30,867 --> 03:42:34,771 SO WE HAVEN'T GONE OUT TO 24 6164 03:42:34,771 --> 03:42:38,742 MONTHS YET, BUT THE OVX, YOU SEE 6165 03:42:38,742 --> 03:42:41,244 NOT A NICE INCREASE IN BONE. 6166 03:42:41,244 --> 03:42:45,415 SO WE DO THINK THERE'S GOING TO 6167 03:42:45,415 --> 03:42:46,182 BE TRANSLATIONAL. 6168 03:42:46,182 --> 03:42:48,552 I THINK THE FRACTIONAL REPAIR 6169 03:42:48,552 --> 03:42:49,886 SAYS THERE'S GOING TO BE A LOT 6170 03:42:49,886 --> 03:42:54,691 OF TRANSLATIONAL PROMISE. 6171 03:42:54,691 --> 03:42:56,826 >> IN TERMS OF TARGETING THE 6172 03:42:56,826 --> 03:42:58,161 BONE, DO YOU THINK IT'S -- I 6173 03:42:58,161 --> 03:43:00,230 KNOW THAT YOU'RE TRYING TO FIND 6174 03:43:00,230 --> 03:43:01,798 A RECEPTOR, BUT DO YOU THINK 6175 03:43:01,798 --> 03:43:04,267 IT'S MORE ON THE OSTEOCLASS SIDE 6176 03:43:04,267 --> 03:43:07,971 OR THE OSTEOLAST? 6177 03:43:07,971 --> 03:43:11,541 I WOULD SPECULATE MAYBE IN 6178 03:43:11,541 --> 03:43:11,741 THE -- 6179 03:43:11,741 --> 03:43:12,509 >> THAT'S A GREAT QUESTION. 6180 03:43:12,509 --> 03:43:14,010 OF COURSE I COULDN'T SHOW ALL 6181 03:43:14,010 --> 03:43:14,978 THAT DATA. 6182 03:43:14,978 --> 03:43:16,613 WE'VE PRETTY MUCH SHOWN THAT 6183 03:43:16,613 --> 03:43:18,882 THIS REALLY IS BONE FORMATION 6184 03:43:18,882 --> 03:43:20,984 AFFECTING OSTEOBLASTS AND NOT 6185 03:43:20,984 --> 03:43:22,519 AFFECTING OSTEOCLASTS. 6186 03:43:22,519 --> 03:43:23,687 OSTEOCLASTS COME ALONG FOR THE 6187 03:43:23,687 --> 03:43:25,655 RIDE, AS WE'RE INCREASING BONE 6188 03:43:25,655 --> 03:43:27,524 FORMATION, BUT WE HAVE NO 6189 03:43:27,524 --> 03:43:29,593 EVIDENCE THAT WE'RE AFFECTING 6190 03:43:29,593 --> 03:43:36,600 OSTEOCLASTS. 6191 03:43:36,600 --> 03:43:39,302 >> JUST FOR THE NON-BONE HEADS, 6192 03:43:39,302 --> 03:43:40,971 I'M A BONE HEAD FROM WAY BACK, I 6193 03:43:40,971 --> 03:43:45,875 GO BACK TO THE EARLY 90s, THE 6194 03:43:45,875 --> 03:43:48,278 NOTION THAT THE OSTEOCYTE IN 6195 03:43:48,278 --> 03:43:50,780 BONE COULD ACTUALLY DEGRADE BONE 6196 03:43:50,780 --> 03:43:55,685 TO MOBILIZE CALCIUM FOR 6197 03:43:55,685 --> 03:43:57,420 LACTATION HAS ONLY BEEN 6198 03:43:57,420 --> 03:44:00,957 DESCRIBED 12 YEARS AGO. 6199 03:44:00,957 --> 03:44:05,061 AND SO THAT WAS LINDA'S GROUP 6200 03:44:05,061 --> 03:44:05,462 THAT DESCRIBED IT. 6201 03:44:05,462 --> 03:44:06,830 AND THE FACT THAT WE NOW HAVE 6202 03:44:06,830 --> 03:44:09,232 THIS HORMONE THAT IS DRIVING 6203 03:44:09,232 --> 03:44:12,702 THAT IS JUST PHENOMENAL 6204 03:44:12,702 --> 03:44:16,106 PROGRESS. 6205 03:44:16,106 --> 03:44:18,408 IT REALLY IS. 6206 03:44:18,408 --> 03:44:20,076 IT JUST TAKES MY BREATH AWAY. 6207 03:44:20,076 --> 03:44:22,078 >> SEE, HE APPRECIATES IT MORE 6208 03:44:22,078 --> 03:44:22,879 THAN I DO, BECAUSE HE KNOWS 6209 03:44:22,879 --> 03:44:28,685 ABOUT BONE. 6210 03:44:28,685 --> 03:44:35,792 SO ANYWAY, THANK YOU VERY MUCH. 6211 03:44:35,792 --> 03:44:37,527 >> I JUST WANTED TO THANK YOU 6212 03:44:37,527 --> 03:44:39,229 FOR ALL YOUR WORK, AND FOR THE 6213 03:44:39,229 --> 03:44:40,597 POINT WHERE YOU SAID YOU MADE A 6214 03:44:40,597 --> 03:44:42,332 DECISION TO STUDY FEMALE 6215 03:44:42,332 --> 03:44:42,966 PHYSIOLOGY, WHICH IS THE 6216 03:44:42,966 --> 03:44:44,367 PRECURSOR TO ALL OF THIS, THANK 6217 03:44:44,367 --> 03:44:45,835 YOU SO MUCH FOR WHAT YOU'VE 6218 03:44:45,835 --> 03:44:48,004 DONE, AND THANK YOU TO RICHARD 6219 03:44:48,004 --> 03:44:48,772 AND NATIONAL INSTITUTE ON AGING 6220 03:44:48,772 --> 03:44:56,546 FOR SUPPORTING THAT WORK. 6221 03:44:56,546 --> 03:44:57,714 >> THANK YOU, EVERYONE. 6222 03:44:57,714 --> 03:44:59,449 I WISH I COULD SAY WE 6223 03:44:59,449 --> 03:45:01,217 ORCHESTRATED THESE TWO TALKS 6224 03:45:01,217 --> 03:45:02,419 INTENTIONALLY, BUT SOMETIMES 6225 03:45:02,419 --> 03:45:03,119 SERENDIPITY WORKS AND THIS IS 6226 03:45:03,119 --> 03:45:04,454 ONE OF THOSE CASES. 6227 03:45:04,454 --> 03:45:05,188 PHENOMENAL AFTERNOON. 6228 03:45:05,188 --> 03:45:07,323 THANK YOU, EVERYBODY, FOR THE 6229 03:45:07,323 --> 03:45:12,996 PRESENTATIONS, PARTICIPATION, 6230 03:45:12,996 --> 03:45:13,930 AND -- GOT IT. 6231 03:45:13,930 --> 03:45:14,631 >> ALL RIGHT. 6232 03:45:14,631 --> 03:45:25,108 THIS CONCLUDES OUR MEETING.