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>> WE'LL GET STARTED. 

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WELCOME, EVERYONE, TO THE 152ND

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NATIONAL ADVISORY COUNCIL ON

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AGING.

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BEFORE I TURN IT OVER TO DR.

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RICHARD HODES, OUR DIRECTOR, I'D

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LIKE TO DO A QUICK ROLL CALL.

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WHEN I READ YOUR NAME IF YOU

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COULD PLEASE GIVE YOUR NAME AND

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INSTITUTION AND WE'LL GO AROUND.

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DR. ESTHANA, DR. BAKER.

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>> PRESENT, MAYO CLINIC.

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>> DR. CASE.

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>> PRESENT, PRINCETON 

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UNIVERSITY.

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>> DR. SILIBERTO.

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>> I'M HERE, AND I
REPRESENT

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FAMILIES LIVING WITH

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ALZHEIMER'S.

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>> AND DR. CRUZ.

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DR. GREENSPAN.

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>> I'M HERE, UNIVERSITY OF

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PITTSBURGH.

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>> DR. HUANG.

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>> I'M HERE, UCSF
GLADSTONE.

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>> REVEREND DR. H O.U.MO.

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>> I'M HERE, REPRESENTING
THOSE

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LIVING WITH ALZHEIMER'S AND

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OTHER DEMENTIA.

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>> DR. ANUIG.

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>> I'M HERE, HARVARD
MEDICAL 

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SCHOOL.

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>> DR. KAHN.

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DR. LONGO.

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>> I'M HERE, STANFORD

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UNIVERSITY.

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>> DR. .

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>> PRESENT, AMERICAN
GERIATRICS

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STOAT.

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>> DR. MANLY.

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>> HERE, ACADEMY COLUMBIA

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UNIVERSITY.

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>> DR. PETERSON.

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>> HERE, UNIVERSITY OF
KENTUCKY.

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>> DR. RUBEN.

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DR. SNYDER.

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>> HERE, RUSH UNIVERSITY
MEDICAL

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CENTER.

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>> DR. VANELDICK.

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>> HELLO, UNIVERSITY OF

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KENTUCKY.

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>> AND DR. WEIR.

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>> PRESENT, UNIVERSITY OF

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MICHIGAN.

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>> WE DO HAVE A FEW EX
OFFICIO

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MEMBERS.

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IS MR. WESTIN HERE?

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NO, OKAY.

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HE WAS HERE YESTERDAY.

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WE ALSO HAVE ATTENDING VIRTUALLY

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DR. APPEL. 

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HASN'T JOINED YET, OKAY.

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AND OKAY, I THINK THAT WILL BE

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IT.

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I'M KEN SANTORA, EXECUTIVE

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SECRETARY FOR THE COUNCIL ON

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AGING, AND THE DIRECTOR OF THE

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DIVISION OF EXTRAMURAL

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ACTIVITIES HERE AT THE AGING

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INSTITUTE.

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SO WITH THAT, I'LL TURN IT OVER

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TO OUR DIRECTOR, DR. RICHARD 

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HODES.

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RICHARD?

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>> THANK YOU, AND WELCOME
TO THE

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152nd. 

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I CAN DO IT.

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I'D LIKE TO SHARE SOME BRIEF

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EVENTS OVER THE TIME SINCE WE

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LAST MET AND EXPRESS PUBLICLY

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DELIGHTED WE'RE MEETING IN

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PERSON WITH ALL OF YOU.

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THE STATUS REPORT, SAD NEWS TO

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SHARE.

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THIS IS NEWS OF A FORMER COUNCIL

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MEMBER NORMAN ANDERSON WHO

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RECENTLY PASSED.

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HE WAS KNOWN TO MANY OF US AS A

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TRUE LEADER IN BEHAVIORAL AND

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SOCIAL SCIENCES, DISTINGUISHED

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YEAR, SUPPORTIVE MENTOR, MEMBER

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OF NATIONAL ACADEMIES.

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WE PAY SPECIAL TRIBUTE AS A

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FORMER COUNCIL MEMBER, FIRST

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FOUNDING DIRECTOR OF THE OFFICE

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OF BEHAVIOR AND SOCIAL SCIENCES

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RESEARCH AT NIH, WHO WAS REALLY

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A TURNING POINT IN THE

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00:03:56,784 --> 00:03:58,653
RECOGNITION, STATURE, VISIBILITY

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OF SOCIAL SCIENCES, BEHAVIORAL

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00:04:00,054 --> 00:04:02,256
AND SOCIAL SCIENCES AT NIH.

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HE REALLY MADE A DIFFERENCE, ONE

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OF THE CO-AUTHORS OF NIA'S

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HEALTH DISPARITIES RESEARCH

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FRAMEWORK AND WANTED TO TAKE A

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MOMENT THEREFORE TO PAUSE IN

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RECOGNITION, ALSO TO ASK IN LIZ

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NEILSEN WANTED TO ADD COMMENTS,

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REFLECTIONS.

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>> YES, THANK YOU,
RICHARD.

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REALLY A TRUE LOSS TO THE FIELD.

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NORM ANDERSON WAS A

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PSYCHOPHYSIOLOGIST, EARLY WORK

114
00:04:30,718 --> 00:04:33,054
BROKE SOME NEW GROUND IN THE

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STUDY OF RACISM AND STRESS, AND

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LINKING THAT TO HYPERTENSION IN

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AFRICAN AMERICANS, CONTRIBUTED 

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TO ONE OF THE FIRST MODELS, LED

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THE FRAMEWORK CHARACTERIZING THE

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RESEARCH CONDUCTED ACROSS THE

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NOTIFY WHICH INFORMED THE

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FRAMEWORK AND WHICH WE PURSUE

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RIGOROUSLY IN BSR ON THIS DAY.

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RICHARD MENTIONED A COMMITMENT

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TO MENTORING THE NEXT GENERATION

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OF SCIENTISTS.

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HE WAS AN ACTIVE CONTRIBUTOR IN

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THE ANNUAL EARLY INVESTIGATORS

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PROGRAM AT ACADEMY OF BEHAVIORAL

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MEDICINE RESEARCH, HELD A LOT OF

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OTHER LEADERSHIP AND SERVICE

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ROLES IN THE FIELD INCLUDING CEO

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OF AMERICAN PSYCHOLOGICAL

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ASSOCIATION AND AT THE TIME OF

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HIS DEATH HE WAS PRESIDENT ELECT

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OF THE FEDERATION OF

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ASSOCIATIONS IN BEHAVIORAL AND

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SOCIAL SCIENCES AND WAS SET TO

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STEP INTO THAT POSITION IN 2026.

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HE WAS ALSO AN EXCEPTIONALLY

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WARM, KIND, THOUGHTFUL PERSON, A

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GENUINE PLEASURE TO BE AROUND,

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AND HIS EARLY AND UNEXPECTED

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DEATH IS REALLY A SHOCK TO THE

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FIELD, A PLEASURE TO BE ABLE TO

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HONOR HIM TODAY.

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>> THANK YOU, LIZ.

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WE REINFORCE ALL THOSE WONDERFUL

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DESCRIPTIVE ADJECTIVES, COULDN'T

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BE MORE PRECISE.

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FOR THOSE WHO HAD THE

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OPPORTUNITY TO KNOW HIM, HE WAS

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AN EXCEPTIONAL PERSON.

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AND WILL BE MISSED. 

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THIS IS THE ANNUAL OPPORTUNITY

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TO TALK TO YOU ABOUT OUR BUDGET,

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ONCE WE HAVE A BUDGET, WHICH

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TYPICALLY HAPPENS AROUND THIS

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LATE POINT OF THE FISCAL YEAR.

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FOR FY 24, THE NIH OVERALL

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BUDGET WAS $48.6 BILLION,

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INCLUDING $4.5 BILLION FOR NIA, 

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INCLUDING $100 MILLION DIRECTED 

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$90 MILLION TO NIA, $10 MILLION

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TO NINDS FOR ADRD, AND 12.5 FOR

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PALLIATIVE CARE.

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IT DOESN'T ADD TO HUNDRED, WE

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SHARE THAT UNDERSTANDING.

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WE'RE THANKFUL, DOING

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EXCEPTIONALLY WELL IN A

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CHALLENGING TIME, GRATEFUL TO

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APPROPRIATORS AGE TO SUPPORT NIA

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AND NIH AND OUR RESEARCHERS.

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THIS IS JUST A VISUAL TO GIVE

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THE SUMMARY OF WHAT'S BEEN

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HAPPENING TO THE NIA

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APPROPRIATIONS YEAR UPON YEAR

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STARTING IN 2014.

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YOU CAN SEE THE EXCEPTIONAL

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GROWTH, TRULY EXCEPTIONAL AND

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HISTORIC SENSE.

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YOU NOTE THE COMPONENT, UPPER

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PORTION OF THE BAR, WHICH IS THE

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TARGET ADRD FUNDS, FASTEST

185
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GROWING COMPONENT, IN ADDITION

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GENERAL BASE HAS GROWN TOO.

187
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NOT MANY PRECEDENTS FOR THIS

188
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LEVEL OF GROWTH REFLECTING

189
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COMMITMENT OF HOUSE, SENATE,

190
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BIPARTISAN OVER MULTIPLE

191
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ADMINISTRATIONS I SHOULD ADD,

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SUPPORTING OUR RESEARCH AND ALL

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OF YOU.

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00:07:44,879 --> 00:07:47,081
THE PAYLINES ARE SUBJECT, SOME

195
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POTENTIAL MODIFICATION AS THE

196
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YEAR CLOSES, BUT ARE SHOWN HERE.

197
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GENERAL PAYLINE FOR THE MOST

198
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COMMON APPLICATIONS UNDER

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00:07:56,357 --> 00:07:58,359
$500,000 DIRECT COST, 16th

200
00:07:58,359 --> 00:08:01,228
PERCENTILE WITH COMMITMENT TO

201
00:08:01,228 --> 00:08:04,031
NEW INVESTIGATORS, AND

202
00:08:04,031 --> 00:08:05,032
EARLY-STAGE INVESTIGATORS, ESI,

203
00:08:05,032 --> 00:08:06,100
19th AND 21st.

204
00:08:06,100 --> 00:08:08,302
GENERAL PAYLINE FOR MORE

205
00:08:08,302 --> 00:08:08,869
EXPENSIVE APPLICATIONS, THE

206
00:08:08,869 --> 00:08:10,371
HIGHER BAR.

207
00:08:10,371 --> 00:08:13,140
AND THIS YEAR FOR AD AND ADRD

208
00:08:13,140 --> 00:08:16,076
THE PAYLINE FOR THOSE

209
00:08:16,076 --> 00:08:20,781
APPLICATIONS UNDER $5 MILLION,

210
00:08:20,781 --> 00:08:25,286
17th PERCENTILE, AGAIN, 20 AND

211
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22.

212
00:08:25,686 --> 00:08:26,821
WE'VE NOTED SUBSTANTIALLY

213
00:08:26,821 --> 00:08:27,855
REDUCED FROM PRIOR YEARS,

214
00:08:27,855 --> 00:08:29,924
REFLECTION OF THE FACT THAT

215
00:08:29,924 --> 00:08:31,892
WE'RE GETTING MORE APPLICATIONS,

216
00:08:31,892 --> 00:08:33,294
MORE MERITORIOUS APPLICATIONS,

217
00:08:33,294 --> 00:08:34,495
MORE EXPENSIVE APPLICATIONS, AND

218
00:08:34,495 --> 00:08:36,063
THAT WE HAD AN INCREASE IN

219
00:08:36,063 --> 00:08:37,798
APPROPRIATION THIS YEAR THE

220
00:08:37,798 --> 00:08:44,071
MAGNITUDE OF THAT INCREASE IS 

221
00:08:44,071 --> 00:08:45,773
SIGNIFICANTLY THAN PRIOR YEARS.

222
00:08:45,773 --> 00:08:49,076
FOR THE NIA REVIEWED

223
00:08:49,076 --> 00:08:51,812
APPLICATIONS, PRIORITY SCORES

224
00:08:51,812 --> 00:08:55,616
NOT PERCENTILES, GENERAL PAYLINE

225
00:08:55,616 --> 00:08:58,786
PROGRAM PROJECTS 25, OTHER 25,

226
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CAREER DEVELOPMENT 22,

227
00:09:00,120 --> 00:09:03,090
FELLOWSHIPS 30, AND FOR ADRD PAY

228
00:09:03,090 --> 00:09:05,392
LINES, SAME FOR PROGRAM PROJECTS

229
00:09:05,392 --> 00:09:06,927
AND NIA REVIEWED RESEARCH,

230
00:09:06,927 --> 00:09:09,563
SLIGHTLY HIGHER PAYLINES FOR

231
00:09:09,563 --> 00:09:10,664
CAREER DEVELOPMENT AND

232
00:09:10,664 --> 00:09:14,568
FELLOWSHIPS.

233
00:09:14,568 --> 00:09:16,203
IN TERMS OF UPDATES, THE NUMBER

234
00:09:16,203 --> 00:09:19,607
OF ACTIVE CLINICAL TRIALS IN AD

235
00:09:19,607 --> 00:09:22,543
AND ADRD IS OVER 500, INCLUDING

236
00:09:22,543 --> 00:09:24,879
22 8 IN DEMENTIA CARE AND

237
00:09:24,879 --> 00:09:29,083
CAREGIVING, FOR THOSE WHICH ARE

238
00:09:29,083 --> 00:09:36,156
TREATMENT AND PREVENT, 73 IN

239
00:09:36,156 --> 00:09:36,924
PHARMACOLOGIC, 177

240
00:09:36,924 --> 00:09:38,759
NON-PHARMACOLOGIC.

241
00:09:38,759 --> 00:09:39,693
AND IMPORTANT AND GRATIFYING

242
00:09:39,693 --> 00:09:41,795
DIVERSITY OF TARGETS IN

243
00:09:41,795 --> 00:09:42,963
INTERVENTIONS.

244
00:09:42,963 --> 00:09:46,333
FOR EXAMPLE, OF THE 73

245
00:09:46,333 --> 00:09:49,203
PHARMACOLOGIC INTERVENTIONS,  60

246
00:09:49,203 --> 00:09:51,272
TRIALS AT EARLY PHASE AMYLOID,

247
00:09:51,272 --> 00:09:52,973
ALTHOUGH PRESENT IN 7,

248
00:09:52,973 --> 00:09:55,309
CONSTITUTES ABOUT 12% OF THE

249
00:09:55,309 --> 00:09:58,412
EARLY STAGE TRIALS, WITH A 

250
00:09:58,412 --> 00:10:03,517
VARIETY OF OTHER TARGETS,

251
00:10:03,517 --> 00:10:04,084
INFLAMMATION, MULTI-TARGETS,

252
00:10:04,084 --> 00:10:05,920
OXIDATIVE STRESS AND SO ON,

253
00:10:05,920 --> 00:10:07,888
RECOGNIZING THE PROGRESS IN

254
00:10:07,888 --> 00:10:08,756
UNDERSTANDING WHAT CONTRIBUTES

255
00:10:08,756 --> 00:10:10,424
TO ALZHEIMER'S DISEASE AND

256
00:10:10,424 --> 00:10:13,360
RELATED DEMENTIAS, AND NOW

257
00:10:13,360 --> 00:10:15,462
MOVING THAT BASIC TRANSLATIONAL

258
00:10:15,462 --> 00:10:17,865
INFORMATION INTO CLINICAL

259
00:10:17,865 --> 00:10:18,866
TRIALS.

260
00:10:18,866 --> 00:10:23,771
SIMILARLY IN THE PHASE 2/3 AND

261
00:10:23,771 --> 00:10:27,708
PHASE 3, AMYLOID 40%, AND

262
00:10:27,708 --> 00:10:29,343
NON-PHARM ALSO MULTIPLE TARGETS

263
00:10:29,343 --> 00:10:33,614
LOOKING AT TREATMENT IN MANY

264
00:10:33,614 --> 00:10:35,716
CASES PREVENTIVE STRATEGIES.

265
00:10:35,716 --> 00:10:37,351
DEMENTIA CARE AND CAREGIVING, I

266
00:10:37,351 --> 00:10:40,087
POINT OUT AS A RESULT OF THE

267
00:10:40,087 --> 00:10:41,855
NATIONAL ACADEMIES REPORT THAT

268
00:10:41,855 --> 00:10:46,026
WE SAW REPORT OUT IN 2021, AND

269
00:10:46,026 --> 00:10:47,995
THE SUMMITS WHICH POINTED OUT

270
00:10:47,995 --> 00:10:48,862
GAPS AND OPPORTUNITIES, EXPAND A

271
00:10:48,862 --> 00:10:50,397
NUMBER OF CLINICAL TRIALS IN

272
00:10:50,397 --> 00:10:52,466
THIS AREA, NO LESS IMPORTANT, NO

273
00:10:52,466 --> 00:10:54,134
LESS RIGOROUS THAT WE CONDUCT

274
00:10:54,134 --> 00:10:55,436
THESE TRIALS FOR CARE AND

275
00:10:55,436 --> 00:10:57,071
CAREGIVING AS WE DO FOR

276
00:10:57,071 --> 00:10:58,672
TREATMENT AND PREVENTION.

277
00:10:58,672 --> 00:11:01,675
AND THEN NUMBERS FOR DIAGNOSTIC

278
00:11:01,675 --> 00:11:03,978
AND IMAGING STUDIES, AND

279
00:11:03,978 --> 00:11:06,480
NEUROPSYCHIATRIC SYMPTOMS.

280
00:11:06,480 --> 00:11:08,449
SO VERY LARGE NUMBER TARGETED

281
00:11:08,449 --> 00:11:11,852
AND INFORMED WAY BY RESEARCH

282
00:11:11,852 --> 00:11:12,720
HAPPENING PRE-CLINICALLY TO

283
00:11:12,720 --> 00:11:14,688
INCREASINGLY DIVERSE TARGETS AS

284
00:11:14,688 --> 00:11:17,558
WE RECOGNIZE THE INDIVIDUAL

285
00:11:17,558 --> 00:11:20,294
DIFFERENCES AMONG -- IN THOSE

286
00:11:20,294 --> 00:11:21,295
PROCESSES CONTRIBUTING TO

287
00:11:21,295 --> 00:11:24,465
DEMENTIA, WHETHER DIAGNOSED AS

288
00:11:24,465 --> 00:11:25,566
ALZHEIMER'S OR RELATED

289
00:11:25,566 --> 00:11:27,401
DEMENTIAS, NEED TO ULTIMATELY

290
00:11:27,401 --> 00:11:32,573
INDIVIDUALIZE TREATMENT TO THOSE

291
00:11:32,573 --> 00:11:34,742
TARGETS INFORMED BY BIOMARKERS

292
00:11:34,742 --> 00:11:37,378
AND UNDERSTANDING OF UNDERRING

293
00:11:37,378 --> 00:11:37,644
PROCESSES.

294
00:11:37,644 --> 00:11:39,780
LAST YEAR FY 23 APPROPRIATIONS

295
00:11:39,780 --> 00:11:41,115
LANGUAGE INCLUDED A DIRECTION

296
00:11:41,115 --> 00:11:45,619
THAT WE CONDUCT FOR THE NATIONAL

297
00:11:45,619 --> 00:11:48,689
ACADEMIES ANALYSIS OF GAPS AND

298
00:11:48,689 --> 00:11:52,693
OPPORTUNITIES FOR PREVENTING AND

299
00:11:52,693 --> 00:11:53,827
TREATING ALZHEIMER'S DISEASE,

300
00:11:53,827 --> 00:11:57,765
VERY MUCH IN PROGRESS, MARCH OF

301
00:11:57,765 --> 00:11:58,866
2023 TASK ORDER ESTABLISHED,

302
00:11:58,866 --> 00:12:01,602
COMMITTEE IN SEPTEMBER LAST

303
00:12:01,602 --> 00:12:03,137
YEAR, PUBLIC MEETINGS OPEN AND

304
00:12:03,137 --> 00:12:05,305
CLOSED SESSIONS WITH FINAL

305
00:12:05,305 --> 00:12:06,407
REPORT ANTICIPATED ABOUT A YEAR

306
00:12:06,407 --> 00:12:09,576
FROM NOW, IN THE JANUARY TO

307
00:12:09,576 --> 00:12:12,646
MARCH 2025, YET ANOTHER INPUT TO

308
00:12:12,646 --> 00:12:13,947
INFORM OUR UNDERSTANDING OF

309
00:12:13,947 --> 00:12:16,250
OPPORTUNITIES AND PRIORITIES FOR

310
00:12:16,250 --> 00:12:20,187
RESEARCH.

311
00:12:20,187 --> 00:12:23,390
GRANT MECHANISMS POINT OUT AGAIN

312
00:12:23,390 --> 00:12:25,459
USE OF PRIZES, THE EUREKA

313
00:12:25,459 --> 00:12:26,693
CHALLENGE NOT LOOKING FOR

314
00:12:26,693 --> 00:12:27,995
APPLICATIONS FOR GRANT TO BE

315
00:12:27,995 --> 00:12:29,963
FUNDED BUT FOR PROPOSALS TO

316
00:12:29,963 --> 00:12:31,932
CARRY OUT RESEARCH, SUCCESSFUL

317
00:12:31,932 --> 00:12:33,267
COMPLETION OF WHICH EARNS A

318
00:12:33,267 --> 00:12:34,435
PRIZE IN THIS COMPETITION, IN

319
00:12:34,435 --> 00:12:37,771
THIS CASE THE CHALLENGE TO 

320
00:12:37,771 --> 00:12:39,273
DISCOVER BEST DATA SOURCES,

321
00:12:39,273 --> 00:12:41,875
METHODS FOR APPLYING, STRATEGIES

322
00:12:41,875 --> 00:12:45,279
FOR EARLY PREDICTION OF

323
00:12:45,279 --> 00:12:48,182
ALZHEIMER'S RELATED DEMENTIAS,

324
00:12:48,182 --> 00:12:50,084
TOTAL CASH PRIZE $650,000 ACROSS

325
00:12:50,084 --> 00:12:53,153
THREE PRAISES, 40 FOR PHASE 1,

326
00:12:53,153 --> 00:12:54,788
PRIZES FOR FIRST PHASE AWARDED

327
00:12:54,788 --> 00:12:56,890
LATER THIS YEAR, SECOND AND

328
00:12:56,890 --> 00:13:01,595
THIRD PHASES TO FOLLOW.

329
00:13:01,595 --> 00:13:03,997
A 2023 SIMILAR PRIZE CHALLENGE

330
00:13:03,997 --> 00:13:06,733
ILLUSTRATED HERE WAS FOR HEALTHY

331
00:13:06,733 --> 00:13:08,936
AGING START-UP, AND IT WAS

332
00:13:08,936 --> 00:13:10,437
REMARKABLY SUCCESSFUL IN THE

333
00:13:10,437 --> 00:13:12,106
DIVERSITY OF PROPOSALS THAT WERE

334
00:13:12,106 --> 00:13:13,507
PUT FORWARD AND FUNDED.

335
00:13:13,507 --> 00:13:19,746
YOU CAN SEE THEY RANGE FROM

336
00:13:19,746 --> 00:13:23,050
ASSISTED WALKING DEVICES THROUGH

337
00:13:23,050 --> 00:13:23,717
IMPLANTATION OF MEDICAL DEVICES,

338
00:13:23,717 --> 00:13:25,452
ACROSS THE BOARD IN TERMS OF

339
00:13:25,452 --> 00:13:31,258
INGENUITY, BUT BRINGING INTO THE

340
00:13:31,258 --> 00:13:33,560
FOLD OF NIA-SUPPORTED RESEARCH A

341
00:13:33,560 --> 00:13:36,063
GROUP OF INVESTIGATORS WHO WOULD

342
00:13:36,063 --> 00:13:37,364
NOT NECESSARILY HAVE TURNED TO

343
00:13:37,364 --> 00:13:38,132
NIH FOR SUPPORT.

344
00:13:38,132 --> 00:13:41,301
WE HOPE WILL ADD TO THE FUTURE

345
00:13:41,301 --> 00:13:43,770
BREADTH OF INGENUITY AND 

346
00:13:43,770 --> 00:13:46,006
INNOVATION IN THE FIELD.

347
00:13:46,006 --> 00:13:47,875
IN TERMS OF DISSEMINATING

348
00:13:47,875 --> 00:13:49,309
PROGRESS, SINCE JANUARY WE LAST

349
00:13:49,309 --> 00:13:52,246
MET, THERE HAVE BEEN PUBLISHED

350
00:13:52,246 --> 00:13:53,247
RESEARCH HIGHLIGHTS, BLOG POSTS,

351
00:13:53,247 --> 00:13:54,348
NEWS OPPORTUNITIES, WHICH I HOPE

352
00:13:54,348 --> 00:13:56,550
YOU ALL HAVE TAKEN ADVANTAGE OF,

353
00:13:56,550 --> 00:13:58,852
AND HAD ACCESS TO.

354
00:13:58,852 --> 00:14:00,487
OVER THAT SAME PERIOD, AMY KELLY

355
00:14:00,487 --> 00:14:03,223
AND I ALONG WITH SENIOR STAFF

356
00:14:03,223 --> 00:14:04,758
PARTICIPATED IN A NUMBER OF

357
00:14:04,758 --> 00:14:06,293
MEETINGS WITH INTEREST GROUPS

358
00:14:06,293 --> 00:14:08,262
AND ADVOCACY GROUPS ALONG WITH

359
00:14:08,262 --> 00:14:09,129
EIGHT CONGRESSIONAL BRIEFINGS

360
00:14:09,129 --> 00:14:10,764
AND HEARINGS.

361
00:14:10,764 --> 00:14:13,066
AND I SHOULD NOTE THAT TOMORROW

362
00:14:13,066 --> 00:14:16,136
ABOUT THIS TIME THERE WILL BE 

363
00:14:16,136 --> 00:14:19,306
THE SENATE APPROPRIATION HEARING

364
00:14:19,306 --> 00:14:20,507
FOR NIH, MONICA BERTAGNOLLI AND

365
00:14:20,507 --> 00:14:22,476
FIVE OF US AS INSTITUTE

366
00:14:22,476 --> 00:14:24,811
DIRECTORS WILL BE PARTICIPATING

367
00:14:24,811 --> 00:14:29,483
IN THAT.

368
00:14:29,483 --> 00:14:30,083
ANNOUNCEMENTS?

369
00:14:30,083 --> 00:14:32,886
THE 50th ANNIVERSARY, IN CASE

370
00:14:32,886 --> 00:14:34,621
ANYBODY MISSED THAT.

371
00:14:34,621 --> 00:14:42,729
IF YOU DO THE ARITHMETIC,

372
00:14:42,729 --> 00:14:44,831
152nd, THREE PER YEAR,

373
00:14:44,831 --> 00:14:46,800
INVITING TO CELEBRATE WHAT WE'VE

374
00:14:46,800 --> 00:14:47,668
ACCOMPLISHED OVER THESE YEARS.

375
00:14:47,668 --> 00:14:50,837
AS A PART OF THAT SPECIAL

376
00:14:50,837 --> 00:14:52,906
ARTICLE PUBLISHED IN JAGS, AND

377
00:14:52,906 --> 00:14:55,642
WE LOOK TO THAT AS A COLLECTION

378
00:14:55,642 --> 00:14:57,844
OF ARTICLES REFLECTING BACK ON

379
00:14:57,844 --> 00:15:04,384
THE ACCOMPLISHMENTS OF NIA AND

380
00:15:04,384 --> 00:15:08,021
NIH-REPORTED RESEARCH.

381
00:15:08,021 --> 00:15:10,691
NOT TO FORGET, THE SCHOLARS

382
00:15:10,691 --> 00:15:12,392
PROGRAM, A MAIN STAY AT JUNIOR

383
00:15:12,392 --> 00:15:13,560
FACULTY AND RESEARCHERS NEW TO

384
00:15:13,560 --> 00:15:15,562
THE AGING FIELD.

385
00:15:15,562 --> 00:15:17,197
WE'RE BACK, IN PERSON, THIS

386
00:15:17,197 --> 00:15:17,397
YEAR.

387
00:15:17,397 --> 00:15:20,934
IN AUGUST WE'LL BE HOLDING THE

388
00:15:20,934 --> 00:15:22,436
MEETING ON THE NIH CAMPUS BACK

389
00:15:22,436 --> 00:15:25,939
THE WAY IT WAS, AFTER SOME VERY

390
00:15:25,939 --> 00:15:27,741
SUCCESSFUL INTERIM YEARS WHEN OF

391
00:15:27,741 --> 00:15:30,711
NECESSITY THIS WAS REMOTE.

392
00:15:30,711 --> 00:15:33,180
AND WE LOOK FORWARD TO

393
00:15:33,180 --> 00:15:35,048
PARTICIPATION, HOPEFULLY FOR

394
00:15:35,048 --> 00:15:38,518
MANY OF YOUR CONTACTS AND

395
00:15:38,518 --> 00:15:38,819
COLLEAGUES.

396
00:15:38,819 --> 00:15:41,822
IF IT'S TOO LATE FOR THIS YEAR'S

397
00:15:41,822 --> 00:15:45,959
APPLICATION, IT'S NOT TOO LATE 

398
00:15:45,959 --> 00:15:47,494
TO THINK ABOUT NEXT YEARS.

399
00:15:47,494 --> 00:15:50,130
THE DOWN SIDE IS WE CAN'T SAY

400
00:15:50,130 --> 00:15:51,765
YES TO EVERYONE, AND SUCCESS THE

401
00:15:51,765 --> 00:15:55,068
SECOND TIME AROUND IS AN

402
00:15:55,068 --> 00:15:57,037
IMPORTANT SUCCESS CRITERION AND

403
00:15:57,037 --> 00:15:59,339
COMPONENT OF OUR GROUP AS WELL.

404
00:15:59,339 --> 00:16:00,540
SO PLEASE, WE'LL KEEP REMINDING

405
00:16:00,540 --> 00:16:01,074
YOU.

406
00:16:01,074 --> 00:16:05,479
WE WON'T LET YOU FORGET.

407
00:16:05,479 --> 00:16:10,951
THE NEXT SUMMIT IN ALZHEIMER'S

408
00:16:10,951 --> 00:16:12,019
DISEASE RESEARCH, PRECISION

409
00:16:12,019 --> 00:16:12,919
MEDICINE, HELD IN SEPTEMBER,

410
00:16:12,919 --> 00:16:14,354
THESE ARE THE DATES.

411
00:16:14,354 --> 00:16:17,157
WE'LL SEND OUT THE REMINDER BUT

412
00:16:17,157 --> 00:16:19,459
INVITE REGISTRATION IN

413
00:16:19,459 --> 00:16:23,096
ATTENDANCE IN PERSON OR REMOTE. 

414
00:16:23,096 --> 00:16:26,933
ONE OF THE CYCLES IS IS THE

415
00:16:26,933 --> 00:16:29,102
RESEARCH SUMMIT, ALZHEIMER'S AND

416
00:16:29,102 --> 00:16:32,973
RELATED DISEASE SUMMIT, THEY 

417
00:16:32,973 --> 00:16:36,376
ROTATE ONE EACH YEAR AND PART OF

418
00:16:36,376 --> 00:16:39,780
THE OVERALL PLANNING PROCESS.

419
00:16:39,780 --> 00:16:41,281
NIH-WIDE UPDATES.  THERE'S A NEW

420
00:16:41,281 --> 00:16:44,351
COMMON FUND PROGRAM, I HOPE ALL

421
00:16:44,351 --> 00:16:48,188
OF YOU UNDERSTAND THE COMMON

422
00:16:48,188 --> 00:16:48,622
FUND.

423
00:16:48,622 --> 00:16:50,557
ACTUALLY OUR SPEAKER TODAY MAY

424
00:16:50,557 --> 00:16:52,859
GIVE YOU A LITTLE MORE INSIGHT.

425
00:16:52,859 --> 00:16:55,495
THIS IS A FUND THAT SUPPORTS

426
00:16:55,495 --> 00:16:57,698
RESEARCH THAT'S OF INTEREST AND

427
00:16:57,698 --> 00:16:58,899
RELEVANCE ACROSS NIH WHICH

428
00:16:58,899 --> 00:17:01,635
CANNOT EASILY BE ACCOMPLISHED BY

429
00:17:01,635 --> 00:17:04,371
A SINGLE INSTITUTE, WHICH FUNDS

430
00:17:04,371 --> 00:17:07,874
BASED ON PROPOSAL, A VERY

431
00:17:07,874 --> 00:17:10,811
COMPETITIVE WAY, THE MOST

432
00:17:10,811 --> 00:17:13,113
MERITORIOUS, FIVE YEARS, TEN

433
00:17:13,113 --> 00:17:14,348
YEARS MAXIMUM, TO INITIATE

434
00:17:14,348 --> 00:17:15,515
RESEARCH AREAS, BUILD FIELDS

435
00:17:15,515 --> 00:17:17,184
WHICH THEN TAKE OVER IN THE

436
00:17:17,184 --> 00:17:18,685
MAINSTREAM OF NIH SUPPORT.

437
00:17:18,685 --> 00:17:21,321
THIS NEW ONE IS ONE OF THE

438
00:17:21,321 --> 00:17:24,958
PRIORITIES OF OUR NIH DIRECTOR,

439
00:17:24,958 --> 00:17:26,893
MONICA BERTAGNOLLI.

440
00:17:26,893 --> 00:17:28,895
THAT'S ESTABLISHMENT OF CLINICAL

441
00:17:28,895 --> 00:17:30,497
RESEARCH PRIMARY CARE NETWORK.

442
00:17:30,497 --> 00:17:32,699
THE NOTION BEING THAT OUR

443
00:17:32,699 --> 00:17:34,668
EFFORTS TO BRING CLINICAL

444
00:17:34,668 --> 00:17:36,303
RESEARCH IN GENERAL, CLINICAL

445
00:17:36,303 --> 00:17:38,271
TRIALS, MORE GENERALLY ALL

446
00:17:38,271 --> 00:17:39,373
CLINICAL RESEARCH, HAS BEEN LESS

447
00:17:39,373 --> 00:17:41,775
THAN IT COULD BE IN REACHING ALL

448
00:17:41,775 --> 00:17:42,542
OF OUR COMMUNITIES AND

449
00:17:42,542 --> 00:17:46,213
UNDERSTANDING A WAY TO CARRY OUT

450
00:17:46,213 --> 00:17:48,248
RESEARCH REACHES COMMUNITIES TO

451
00:17:48,248 --> 00:17:49,583
DO RESEARCH IN AND PARTICIPATION

452
00:17:49,583 --> 00:17:50,450
OF THOSE COMMUNITIES.

453
00:17:50,450 --> 00:17:53,620
AND THE USE OF PRIMARY CARE

454
00:17:53,620 --> 00:17:54,521
SETTINGS IN THIS NETWORK IS PART

455
00:17:54,521 --> 00:17:58,392
OF THAT GOAL SO A GROUP OF US,

456
00:17:58,392 --> 00:18:00,494
INSTITUTE DIRECTORS SERVING ON

457
00:18:00,494 --> 00:18:02,462
THE OVERSIGHT GROUP, ANOTHER

458
00:18:02,462 --> 00:18:04,998
GROUP, SO-CALLED SCIENCE

459
00:18:04,998 --> 00:18:07,401
COMMITTEE WHICH AMY KELLEY WILL

460
00:18:07,401 --> 00:18:09,169
SERVE, GIVING NIA AN IMPORTANT

461
00:18:09,169 --> 00:18:10,570
PARTICIPATORY ROLE IN THIS.

462
00:18:10,570 --> 00:18:20,814
WE CAN REPORT BACK AS THIS

463
00:18:20,814 --> 00:18:21,081
DEVELOPS.

464
00:18:21,081 --> 00:18:23,717
STAFF UPDATES, YOU MET IN

465
00:18:23,717 --> 00:18:24,785
BREAKOUT SESSIONS YESTERDAY

466
00:18:24,785 --> 00:18:26,653
WE'VE SEEN GREAT GROWTH OF

467
00:18:26,653 --> 00:18:28,188
NECESSITY GIVEN THE EXPANSION OF

468
00:18:28,188 --> 00:18:29,523
THE RESEARCH WE SUPPORT, SO WE'D

469
00:18:29,523 --> 00:18:32,793
LIKE TO GO THROUGH AND HAVE EACH

470
00:18:32,793 --> 00:18:35,629
OF OUR DIVISION DIRECTORS

471
00:18:35,629 --> 00:18:37,531
INTRODUCE RESPECTIVELY NEW STAFF

472
00:18:37,531 --> 00:18:39,266
IN THEIR DIVISION.

473
00:18:39,266 --> 00:18:39,900
>> I'LL START.

474
00:18:39,900 --> 00:18:42,035
FOR DIVISION OF BEHAVIORAL AND

475
00:18:42,035 --> 00:18:47,808
SOCIAL RESEARCH, I'D LIKE TO 

476
00:18:47,808 --> 00:18:49,643
INTRODUCE MS. LESLEY GORED, A

477
00:18:49,643 --> 00:18:51,511
CLINICAL TRIALS SPECIALIST.

478
00:18:51,511 --> 00:18:53,480
CONDUCTING STEWARDSHIP AND

479
00:18:53,480 --> 00:18:57,250
OVERSIGHT FOR BSR'S CLINICAL

480
00:18:57,250 --> 00:19:00,487
TRIALS PORTFOLIO, PRE AND POST

481
00:19:00,487 --> 00:19:02,022
AWARD POLICY COMPLIANCE, RISK

482
00:19:02,022 --> 00:19:03,023
ASSESSMENTS, CONFLICT OF

483
00:19:03,023 --> 00:19:05,625
INTEREST REVIEWS FOR SAFETY,

484
00:19:05,625 --> 00:19:06,159
OVERSIGHT.

485
00:19:06,159 --> 00:19:08,028
PRIOR TO JOINING BSR LESLIE

486
00:19:08,028 --> 00:19:10,130
MANAGED A CONTRACT THAT PROVIDED

487
00:19:10,130 --> 00:19:11,865
CLINICAL TRIALS STUDIES

488
00:19:11,865 --> 00:19:13,834
MANAGEMENT SUPPORT AT NIAMS, AND

489
00:19:13,834 --> 00:19:18,205
HOLDS A B.A. IN PSYCHOLOGY FROM

490
00:19:18,205 --> 00:19:19,739
EMORY.

491
00:19:19,739 --> 00:19:30,283
NEXT MS. CATHONY REID, AD/ADRD 

492
00:19:31,418 --> 00:19:32,085
STRATEGY COORDINATION, HEALTH

493
00:19:32,085 --> 00:19:32,385
SPECIALIST.

494
00:19:32,385 --> 00:19:35,922
SHE COMES TO US FROM THE CDC IN

495
00:19:35,922 --> 00:19:38,425
ATLANTA, WAS A PROJECT OFFICER

496
00:19:38,425 --> 00:19:39,860
OVERSEEING PORTFOLIOS FOR

497
00:19:39,860 --> 00:19:42,062
NON-GOVERNMENTAL AGENCIES.

498
00:19:42,062 --> 00:19:43,797
SHIELDS MPH FROM GEORGIA

499
00:19:43,797 --> 00:19:44,698
SOUTHERN UNIVERSITY, WORKING ON

500
00:19:44,698 --> 00:19:50,270
DOCTOR IN PUBLIC HEALTH AT

501
00:19:50,270 --> 00:19:53,139
MERCER UNIVERSITY, DIVERSE

502
00:19:53,139 --> 00:19:54,708
POPULATIONS AND HEALTH EQUALITY.

503
00:19:54,708 --> 00:20:01,848
IN THE OFFICE OF DATA RESOURCES

504
00:20:01,848 --> 00:20:05,819
AND ANALYTICS

505
00:20:05,819 --> 00:20:08,788
WAS PROMOTED TO SUPERVISORY

506
00:20:08,788 --> 00:20:10,991
POSITION, DR. ALI HOLDS A

507
00:20:10,991 --> 00:20:12,092
Ph.D. FROM STONY BROOK, COMES

508
00:20:12,092 --> 00:20:14,261
AFTER 12 YEARS IN THE DEPARTMENT

509
00:20:14,261 --> 00:20:15,695
OF HEALTH AND HUMAN SERVICES,

510
00:20:15,695 --> 00:20:18,465
MOST RECENTLY OFFICE OF THE

511
00:20:18,465 --> 00:20:20,000
ASSISTANT SECRETARY FOR PLANNING

512
00:20:20,000 --> 00:20:22,936
AND EVALUATION, SENIOR HEALTH

513
00:20:22,936 --> 00:20:23,470
ECONOMIST.

514
00:20:23,470 --> 00:20:26,006
PRIOR TO JOINING HHS MIR WAS

515
00:20:26,006 --> 00:20:26,506
ASSISTANT PROFESSOR OF

516
00:20:26,506 --> 00:20:33,813
ECONOMICS, UNIVERSITY OF TOLEDO.

517
00:20:33,813 --> 00:20:36,750
MS.TAYLOR CUSHRER JOINED IN MAY,

518
00:20:36,750 --> 00:20:38,051
SHE'S WORKING ON INITIATIVES

519
00:20:38,051 --> 00:20:40,887
RELATED TO REAL WORLD DATA, DATA

520
00:20:40,887 --> 00:20:43,089
SCIENCE, ARTIFICIAL

521
00:20:43,089 --> 00:20:43,423
INTELLIGENCE.

522
00:20:43,423 --> 00:20:48,495
SHE JOINS FROM  BIOGEN DIGITAL

523
00:20:48,495 --> 00:20:50,897
HEALTH, MANAGED A NETWORK FOR

524
00:20:50,897 --> 00:20:51,665
MULTIPLE SCLEROSIS AND

525
00:20:51,665 --> 00:20:53,400
EXPERIENCE IS REAL WORLD STUDIES

526
00:20:53,400 --> 00:20:56,670
IN CANCER AND PATIENT

527
00:20:56,670 --> 00:21:03,843
ENGAGEMENT,  MASTER'S IN PUBLIC

528
00:21:03,843 --> 00:21:06,212
HEALTH, BACHELOR'S IN

529
00:21:06,212 --> 00:21:06,680
KINESIOLOGY.

530
00:21:06,680 --> 00:21:10,717
LAST BUT NOT LEAST MS. MELISSA

531
00:21:10,717 --> 00:21:14,454
STRIKER, A PROGRAM ANALYST, 

532
00:21:14,454 --> 00:21:17,490
FOURTH MELISSA IN BSR.

533
00:21:17,490 --> 00:21:19,025
SHE'S SERVING AS CONTRACT

534
00:21:19,025 --> 00:21:21,094
OFFICER FOR SCIENCE MANAGEMENT

535
00:21:21,094 --> 00:21:24,731
AND RESEARCH ADMINISTRATION

536
00:21:24,731 --> 00:21:26,132
CONTRACT AND SBIR CONTRACTS,

537
00:21:26,132 --> 00:21:27,567
COORDINATING PROCESS FOR

538
00:21:27,567 --> 00:21:29,002
DEVELOPING AND SUBMITTING

539
00:21:29,002 --> 00:21:31,705
FUNDING OPPORTUNITIES TO THE

540
00:21:31,705 --> 00:21:37,877
COMPLEX NIH FOAM SYSTEM, WE'RE

541
00:21:37,877 --> 00:21:38,345
GRATEFUL.

542
00:21:38,345 --> 00:21:39,412
SHE GAINED VALUABLE EXPERIENCE

543
00:21:39,412 --> 00:21:41,615
FOR BOTH HER CONTRACTING AND

544
00:21:41,615 --> 00:21:43,149
FUNDING OPPORTUNITY DEVELOPMENT

545
00:21:43,149 --> 00:21:43,350
ROLES.

546
00:21:43,350 --> 00:21:52,626
PRIOR TO WORKING  INTEREST, 

547
00:21:52,626 --> 00:21:57,564
WORKED AT CSR.

548
00:21:57,564 --> 00:21:58,331
>> THANK YOU.

549
00:21:58,331 --> 00:22:01,401
>> PLEASE WELCOME FROM THE

550
00:22:01,401 --> 00:22:02,802
UNIVERSITY OF KENTUCKY,

551
00:22:02,802 --> 00:22:08,842
EPIDEMIOLOGIC RESEARCH ON BREAST

552
00:22:08,842 --> 00:22:11,678
CANCER, CHUNYAN HE, FOCUSING ON

553
00:22:11,678 --> 00:22:14,681
LONGITUDINAL AGENCY OF THE

554
00:22:14,681 --> 00:22:15,548
LIFESPAN, WE PARTICULARLY

555
00:22:15,548 --> 00:22:16,282
APPRECIATE BECAUSE OF THE

556
00:22:16,282 --> 00:22:20,220
GROWING INTEREST IN THAT TOPIC

557
00:22:20,220 --> 00:22:26,793
IN RELATIONSHIP TO AGING. 

558
00:22:26,793 --> 00:22:28,094
>> GOOD MORNING.

559
00:22:28,094 --> 00:22:29,663
IS THIS ON?

560
00:22:29,663 --> 00:22:29,996
YEAH.

561
00:22:29,996 --> 00:22:30,864
ALL RIGHT.

562
00:22:30,864 --> 00:22:32,599
FOR THE DIVISION OF

563
00:22:32,599 --> 00:22:36,436
NEUROSCIENCE, I WOULD LIKE TO

564
00:22:36,436 --> 00:22:40,607
INTRODUCE MEGAN DUFFY, JOINED

565
00:22:40,607 --> 00:22:42,142
FROM THE POSTDOCTORAL POSITION

566
00:22:42,142 --> 00:22:44,310
IN CELL BIOLOGY AND GENE

567
00:22:44,310 --> 00:22:45,879
EXPRESSION FROM OUR NIA

568
00:22:45,879 --> 00:22:48,915
INTRAMURAL PROGRAM AND PRIOR TO

569
00:22:48,915 --> 00:22:51,985
THAT MEGAN GOT A Ph.D. DEGREE

570
00:22:51,985 --> 00:22:52,652
NEUROSCIENCE FROM MICHIGAN STATE

571
00:22:52,652 --> 00:22:55,288
UNIVERSITY WHERE SHE WAS WORKING

572
00:22:55,288 --> 00:22:59,325
IN DEPARTMENT OF TRANSLATIONAL

573
00:22:59,325 --> 00:22:59,826
NEUROSCIENCE, WORKING ON

574
00:22:59,826 --> 00:23:03,930
PARKINSON'S DISEASE, DIVISION OF

575
00:23:03,930 --> 00:23:06,132
NEUROSCIENCE SHE'S SUPPORTING

576
00:23:06,132 --> 00:23:09,736
PROGRAMS IN BASIC BRAIN AGING

577
00:23:09,736 --> 00:23:11,171
AND NETWORK DEGENERATIVE

578
00:23:11,171 --> 00:23:15,475
PROCESSES IN THE NEUROBIOLOGY OF

579
00:23:15,475 --> 00:23:19,079
AGING AND NEURODEGENERATION

580
00:23:19,079 --> 00:23:22,015
BRANCH.

581
00:23:22,015 --> 00:23:23,016
LAUREN KOMER, PROGRAM SPECIALIST

582
00:23:23,016 --> 00:23:25,852
ALSO, IN THE NEUROBIOLOGY OF

583
00:23:25,852 --> 00:23:27,887
AGING AND NEURODEGENERATION

584
00:23:27,887 --> 00:23:30,690
BRANCH, SUPPORTING PROGRAMS IN

585
00:23:30,690 --> 00:23:31,658
BRAIN AGING AND

586
00:23:31,658 --> 00:23:32,058
NEURODEGENERATION.

587
00:23:32,058 --> 00:23:35,595
SHE JOINED US FROM THE

588
00:23:35,595 --> 00:23:41,367
NATIONAL -- THE NEW YORK ACADEMY

589
00:23:41,367 --> 00:23:44,237
OF SCIENCE, WHERE SHE WAS

590
00:23:44,237 --> 00:23:46,906
PREVIOUSLY WORKING, AND SHE

591
00:23:46,906 --> 00:23:49,242
RECEIVED HER DEGREE, Ph.D.

592
00:23:49,242 --> 00:23:50,343
DEGREE, FROM CORNELL UNIVERSITY

593
00:23:50,343 --> 00:23:55,281
WHERE SHE WAS ALSO WORKING ON

594
00:23:55,281 --> 00:23:56,916
PARKINSON'S DISEASE AND

595
00:23:56,916 --> 00:24:00,086
SYNUCLEIN OPATHIES, DOING REALLY

596
00:24:00,086 --> 00:24:00,887
EXCEPTIONAL BASIC SCIENCE WORK

597
00:24:00,887 --> 00:24:05,225
AT THE TIME. 

598
00:24:05,225 --> 00:24:07,427
NEXT ONE PLEASE.

599
00:24:07,427 --> 00:24:09,829
TIFFANY IS SUPPORTING PROGRAMS

600
00:24:09,829 --> 00:24:12,565
IN FUNCTIONAL GENOMICS AND

601
00:24:12,565 --> 00:24:14,834
GENETICS, SHE JOINED US FROM

602
00:24:14,834 --> 00:24:16,202
CENTER FROM STRATEGIC

603
00:24:16,202 --> 00:24:18,671
INITIATIVES AT THE MILKEN

604
00:24:18,671 --> 00:24:20,907
INSTITUTE, AND SHE'S HEALTH

605
00:24:20,907 --> 00:24:23,510
SPECIALIST WORKING ON THE

606
00:24:23,510 --> 00:24:27,380
POPULATION AND GENETICS BRANCH 

607
00:24:27,380 --> 00:24:28,982
OF THE DIVISION.

608
00:24:28,982 --> 00:24:32,819
TIFFANY HAS A DEGREE IN GENETICS

609
00:24:32,819 --> 00:24:34,654
AND GENOMICS FROM BAYLOR

610
00:24:34,654 --> 00:24:37,757
UNIVERSITY, AND FOLLOWING THAT

611
00:24:37,757 --> 00:24:43,429
DEGREE SHE HAD A FELLOWSHIP AT

612
00:24:43,429 --> 00:24:48,368
THE ASAG AND NHGRI, AND

613
00:24:48,368 --> 00:24:49,669
SUBSEQUENTLY STUDIES MANAGE THE

614
00:24:49,669 --> 00:24:54,140
PROGRAMS IN SCIENCE EDUCATION

615
00:24:54,140 --> 00:24:57,644
AND STRATEGIC CONSULTING.

616
00:24:57,644 --> 00:25:01,047
AND JANELLE FORET JOINED AS

617
00:25:01,047 --> 00:25:03,149
HEALTH SPECIALIST, WITH THE

618
00:25:03,149 --> 00:25:06,953
BRANCH OF POPULATION AND

619
00:25:06,953 --> 00:25:09,923
GENETICS, AND SHE ALSO HAS

620
00:25:09,923 --> 00:25:11,691
SIGNIFICANT EXPERIENCE ON

621
00:25:11,691 --> 00:25:13,960
POPULATION STUDIES AND

622
00:25:13,960 --> 00:25:16,229
EPIDEMIOLOGY. 

623
00:25:16,229 --> 00:25:19,966
SHE RECEIVED HER NEUROPSYCHOLOGY

624
00:25:19,966 --> 00:25:23,136
DEGREE FROM UT AUSTIN, AND WENT

625
00:25:23,136 --> 00:25:27,173
ON TO DO ADDITIONAL FELLOWSHIP

626
00:25:27,173 --> 00:25:30,844
RESEARCH AT UC-SAN DIEGO,

627
00:25:30,844 --> 00:25:32,445
INTERSECTION OF COGNITIVE AGING

628
00:25:32,445 --> 00:25:37,951
AND WOMEN'S HEALTH AND

629
00:25:37,951 --> 00:25:38,918
IDENTIFICATION OF CARDIOVASCULAR

630
00:25:38,918 --> 00:25:40,653
NEUROCOGNITIVE CHANGES.

631
00:25:40,653 --> 00:25:47,794
NEXT ONE PLEASE.

632
00:25:47,794 --> 00:25:50,296
AND SARAH HELLMUND, DATA

633
00:25:50,296 --> 00:25:51,164
SCIENTISTS PROVIDING SUPPORT,

634
00:25:51,164 --> 00:25:54,801
PARTICULARLY AS RELATES NOW WITH

635
00:25:54,801 --> 00:25:56,102
THE GROWTH ON APPLICATIONS

636
00:25:56,102 --> 00:25:59,272
INVOLVING A.I. AND ML AND ALSO

637
00:25:59,272 --> 00:26:04,077
INVOLVING ALL THE NEW DATA

638
00:26:04,077 --> 00:26:05,745
MANAGEMENT AND SHARING

639
00:26:05,745 --> 00:26:09,449
REQUIREMENTS AND ALL THE OTHER

640
00:26:09,449 --> 00:26:13,052
DATA MANAGEMENT NEEDS WITHIN THE

641
00:26:13,052 --> 00:26:13,386
DIVISION.

642
00:26:13,386 --> 00:26:22,462
SHE JOINS FROM THE  BOOZ ALLEN

643
00:26:22,462 --> 00:26:23,696
HAMILTON, SUPPORTING NIH

644
00:26:23,696 --> 00:26:26,199
PROGRAMS, A MASTER'S DEGREE FROM

645
00:26:26,199 --> 00:26:30,703
HOPKINS UNIVERSITY AND B.S. 

646
00:26:30,703 --> 00:26:33,206
PUBLIC HEALTH DEGREE FROM OHIO

647
00:26:33,206 --> 00:26:39,679
STATE UNIVERSITY. 

648
00:26:39,679 --> 00:26:40,680
AND FINALLY ANTOINETTE

649
00:26:40,680 --> 00:26:41,981
PERCY-LAURRRY, PROGRAM DIRECTOR,

650
00:26:41,981 --> 00:26:45,318
ALSO IN THE POPULATION AND

651
00:26:45,318 --> 00:26:47,453
GENETICS BRANCH, SUPPORTING A

652
00:26:47,453 --> 00:26:50,857
NUMBER OF PROGRAMS RELATED TO

653
00:26:50,857 --> 00:26:52,592
EPIDEMIOLOGY AND HEALTH

654
00:26:52,592 --> 00:26:54,360
DISPARITIES AND DIVERSITY.

655
00:26:54,360 --> 00:26:59,165
AND SHE HAS A TREMENDOUS 

656
00:26:59,165 --> 00:27:02,669
EXPERIENCE IN THOSE AREAS, SHE

657
00:27:02,669 --> 00:27:08,274
PREVIOUSLY WORKED AT NIMHD AND

658
00:27:08,274 --> 00:27:18,584
NCI, AND SHE HAS MULTIPLE 

659
00:27:18,584 --> 00:27:23,289
DEGREES ON PUBLIC HEALTH

660
00:27:23,289 --> 00:27:24,590
INCLUDING DR PH.

661
00:27:24,590 --> 00:27:24,924
SO THANK YOU.

662
00:27:24,924 --> 00:27:25,692
>> ALL RIGHT.

663
00:27:25,692 --> 00:27:29,095
NEXT UP IS DIVISION OF

664
00:27:29,095 --> 00:27:30,530
EXTRAMURAL ACTIVITIES, HAPPY TO

665
00:27:30,530 --> 00:27:34,667
INTRODUCE FOUR NEW MEMBERS TO

666
00:27:34,667 --> 00:27:37,403
OUR FAMILY.

667
00:27:37,403 --> 00:27:40,273
FIRST OFF, SCIENTIFIC REVIEW

668
00:27:40,273 --> 00:27:41,040
BRANCHI JAMES NUCCI.

669
00:27:41,040 --> 00:27:45,545
HE'S GOING TO BE AN EXTRAMURAL

670
00:27:45,545 --> 00:27:47,080
STAFF ASSISTANT, PROVIDING

671
00:27:47,080 --> 00:27:48,381
ADMINISTRATIVE SUPPORT FOR

672
00:27:48,381 --> 00:27:50,450
SCIENTIFIC REVIEW GROUP.

673
00:27:50,450 --> 00:27:54,420
HE'S JOINING FROM THE CANCER

674
00:27:54,420 --> 00:27:56,723
INSTITUTE, PREVIOUSLY WAS AT THE

675
00:27:56,723 --> 00:27:57,690
AGING INSTITUTE AND HE

676
00:27:57,690 --> 00:28:00,093
UNDERSTOOD THE ERROR OF HIS WAYS

677
00:28:00,093 --> 00:28:01,761
AND CAME BACK AS HE KNOWS WE'RE

678
00:28:01,761 --> 00:28:05,565
THE BETTER OF THE INSTITUTES.

679
00:28:05,565 --> 00:28:10,403
NEXT UP IS DR. LISA WIGFALL, SHE

680
00:28:10,403 --> 00:28:15,208
IS AN SRO, WILL BECOME AN SRO IN

681
00:28:15,208 --> 00:28:17,944
THE SOCIAL AND BEHAVIORAL

682
00:28:17,944 --> 00:28:18,711
SCIENCE SECTION.

683
00:28:18,711 --> 00:28:23,216
WE'RE VERY FORTUNATE TO HAVE HER

684
00:28:23,216 --> 00:28:25,618
AS SHE JOINS FROM CENTER FOR

685
00:28:25,618 --> 00:28:27,020
SCIENTIFIC REVIEW WHICH SHE

686
00:28:27,020 --> 00:28:30,957
SUPPORTED SIMILAR STUDY

687
00:28:30,957 --> 00:28:32,859
CONNECTION IN CSR, AND NOW JOINS

688
00:28:32,859 --> 00:28:35,795
OUR SCIENTIFIC REVIEW PROGRAM.

689
00:28:35,795 --> 00:28:36,095
NEXT SLIDE.

690
00:28:36,095 --> 00:28:38,931
NEXT IS A NEW MEMBER OF OUR

691
00:28:38,931 --> 00:28:44,270
OFFICE OF CLINICAL RESEARCH.

692
00:28:44,270 --> 00:28:50,510
WE HAVE MISS CLARISSA VINCENT,

693
00:28:50,510 --> 00:28:51,477
CLINICAL OPERATIONS SPECIALIST,

694
00:28:51,477 --> 00:28:53,479
IN CLINICAL OPERATIONS AND

695
00:28:53,479 --> 00:28:56,315
SUPPORT BRANCH.

696
00:28:56,315 --> 00:28:58,317
LET'S SEE.

697
00:28:58,317 --> 00:28:59,719
MS.VINCENT WILL BE PARTICIPATING

698
00:28:59,719 --> 00:29:01,487
IN THE DEVELOPMENT AND

699
00:29:01,487 --> 00:29:03,890
IMPLEMENTATION OF OUR STRATEGIES

700
00:29:03,890 --> 00:29:06,292
TO EVALUATE AND MONITOR CLINICAL

701
00:29:06,292 --> 00:29:08,027
OPERATIONS AND ENROLLMENT

702
00:29:08,027 --> 00:29:09,996
PROCESSES IN THE RESEARCH

703
00:29:09,996 --> 00:29:13,066
SUPPORT OF NIA AND SHE JOINS US

704
00:29:13,066 --> 00:29:14,667
FROM A CONTRACT POSITION AT

705
00:29:14,667 --> 00:29:16,903
MENTAL HEALTH INSTITUTE AS A

706
00:29:16,903 --> 00:29:18,671
CLINICAL RESEARCH ADVISER AND

707
00:29:18,671 --> 00:29:19,072
MONITOR.

708
00:29:19,072 --> 00:29:20,973
SO WE'RE HAPPY TO HAVE

709
00:29:20,973 --> 00:29:23,276
MS. VINCENT JOIN US.

710
00:29:23,276 --> 00:29:25,812
AND NEXT IS FINALLY WE HAVE A

711
00:29:25,812 --> 00:29:32,685
NEW MEMBER OF OUR OFFICE OF 

712
00:29:32,685 --> 00:29:33,886
STRATEGIC EXTRAMURAL PROGRAM,

713
00:29:33,886 --> 00:29:36,956
DR. VICKY CATTANI, JOINS US FROM

714
00:29:36,956 --> 00:29:38,591
THE PARKINSON'S FOUNDATION, SHE

715
00:29:38,591 --> 00:29:39,625
WAS ASSOCIATE DIRECTOR OF

716
00:29:39,625 --> 00:29:42,395
RESEARCH PROGRAMS THERE AT THE

717
00:29:42,395 --> 00:29:43,296
FOUNDATION.

718
00:29:43,296 --> 00:29:46,232
AND HER ROLE WILL BE TO PROMOTE

719
00:29:46,232 --> 00:29:49,402
AND SUPPORT SMALL BUSINESSES,

720
00:29:49,402 --> 00:29:51,170
SEEKING SBIR/STTR FUNDING IN THE

721
00:29:51,170 --> 00:29:52,238
AGE TECH SPACE.

722
00:29:52,238 --> 00:29:56,209
SHE WILL BE HELPING SMALL BILLS

723
00:29:56,209 --> 00:29:57,510
AWARDEES ADVANCE TOWARD THEIR

724
00:29:57,510 --> 00:29:57,910
COMMERCIALIZATION.

725
00:29:57,910 --> 00:30:01,781
WE WELCOME THESE FOUR NEW 

726
00:30:01,781 --> 00:30:02,148
MEMBERS TO DEA.

727
00:30:02,148 --> 00:30:04,317
>> GOOD MORNING, IT'S MY

728
00:30:04,317 --> 00:30:07,253
PLEASURE TO TWO NEW OFFICE OF

729
00:30:07,253 --> 00:30:09,122
ADMINISTRATIVE MANAGEMENT STAFF,

730
00:30:09,122 --> 00:30:11,424
FIRST IS JILL OLAND, NEW ETHICS

731
00:30:11,424 --> 00:30:16,562
SPECIALIST IN OUR ETHICS BRANCH,

732
00:30:16,562 --> 00:30:18,331
WHO WILL PROVIDE OVERSIGHT AND

733
00:30:18,331 --> 00:30:19,966
REVIEW FROM NATIONAL

734
00:30:19,966 --> 00:30:21,400
TRANSPORTATION SECURITY

735
00:30:21,400 --> 00:30:21,767
ADMINISTRATION.

736
00:30:21,767 --> 00:30:25,671
NEXT WE HAVE NED FREEMAN, I.T.

737
00:30:25,671 --> 00:30:27,206
PROJECT MANAGER IN INFORMATION

738
00:30:27,206 --> 00:30:30,576
TECHNOLOGY BRANCH, SERVING AS A

739
00:30:30,576 --> 00:30:32,011
TECHNOLOGY PROJECT MANAGER FOR

740
00:30:32,011 --> 00:30:34,614
NIA EFFORTS, JOINS US FROM MOSER

741
00:30:34,614 --> 00:30:37,283
GOVERNMENT SERVICES WHERE HE WAS

742
00:30:37,283 --> 00:30:42,054
A PRINCIPAL CONSULTANT.

743
00:30:42,054 --> 00:30:43,189
THANK YOU.

744
00:30:43,189 --> 00:30:45,158
>> GOOD MORNING, I'M
PLEASED TO

745
00:30:45,158 --> 00:30:46,359
INTRODUCE FOUR NEW MEMBERS OF

746
00:30:46,359 --> 00:30:48,561
THE NIA OFFICE OF COMMUNICATIONS

747
00:30:48,561 --> 00:30:49,896
AND PUBLIC LIAISON.

748
00:30:49,896 --> 00:30:53,366
FIRST WE HAVE MARY HERON,

749
00:30:53,366 --> 00:30:55,101
TECHNICAL WRITER/EDITOR, HEALTH

750
00:30:55,101 --> 00:30:56,802
COMMUNICATIONS BRANCH, WORKING

751
00:30:56,802 --> 00:31:00,940
ON OUR ONLINE CONSUMER HEALTH

752
00:31:00,940 --> 00:31:01,941
INFORMATION AND PUBLICATIONS,

753
00:31:01,941 --> 00:31:03,676
AIMED AT GENERAL PUBLIC.

754
00:31:03,676 --> 00:31:07,914
THERE'S A FOCUS IN HER WORK ON

755
00:31:07,914 --> 00:31:08,915
CAREGIVING, HEALTHCARE

756
00:31:08,915 --> 00:31:09,882
PROFESSIONALS, CLINICAL

757
00:31:09,882 --> 00:31:10,349
RESEARCH.

758
00:31:10,349 --> 00:31:12,652
MARY JOINED NIA FROM THE NIH

759
00:31:12,652 --> 00:31:13,519
NATIONAL LIBRARY OF MEDICINE

760
00:31:13,519 --> 00:31:16,255
WHERE SHE WAS AN EDITOR.

761
00:31:16,255 --> 00:31:19,725
WE ALSO HAVE TONY JARMUSZ, ALSO

762
00:31:19,725 --> 00:31:23,462
A WRITER/EDITOR IN THE HEALTH

763
00:31:23,462 --> 00:31:24,797
COMMUNICATIONS BRANCH, FOCUSING

764
00:31:24,797 --> 00:31:26,732
ON TELLING STORIES OF NIA

765
00:31:26,732 --> 00:31:28,501
RESEARCH THROUGH SCIENCE WRITING

766
00:31:28,501 --> 00:31:30,236
AND FEATURE ARTICLES.

767
00:31:30,236 --> 00:31:31,871
AND HE'S ALSO CREATING AND

768
00:31:31,871 --> 00:31:34,407
UPDATING SOME OF OUR HEALTH

769
00:31:34,407 --> 00:31:36,742
INFORMATION ONLINE AND IN PRINT.

770
00:31:36,742 --> 00:31:38,644
TONY JOINED NIA FROM NIH

771
00:31:38,644 --> 00:31:40,646
NATIONAL INSTITUTE ON MENTAL

772
00:31:40,646 --> 00:31:44,817
HEALTH, WHERE HE WAS ALSO A

773
00:31:44,817 --> 00:31:45,117
WRITER.

774
00:31:45,117 --> 00:31:46,352
NEXT PLEASE.

775
00:31:46,352 --> 00:31:48,120
MORGAN MOORE IS A SOCIAL MEDIA

776
00:31:48,120 --> 00:31:50,656
SPECIALIST, NEW TO OUR OUTREACH

777
00:31:50,656 --> 00:31:52,625
AND DIGITAL ENGAGEMENT BRANCH.

778
00:31:52,625 --> 00:31:54,694
AND SHE'S HELPING TO COORDINATE

779
00:31:54,694 --> 00:31:56,762
OUR E-MAIL MARKETING EFFORTS,

780
00:31:56,762 --> 00:31:58,631
MANAGING OUR SOCIAL MEDIA

781
00:31:58,631 --> 00:32:00,700
CHANNELS, AND SUPPORTING OTHER

782
00:32:00,700 --> 00:32:01,601
OUTREACH EFFORTS.

783
00:32:01,601 --> 00:32:04,770
SHE'S ALSO DEVELOPING AND

784
00:32:04,770 --> 00:32:07,707
UPDATING WEBSITE CONTENT.

785
00:32:07,707 --> 00:32:10,209
MORGAN JOINED FROM TUXCARE, I.T.

786
00:32:10,209 --> 00:32:14,313
RELATED, A SENIOR SOCIAL MEDIA

787
00:32:14,313 --> 00:32:14,547
MANAGER.

788
00:32:14,547 --> 00:32:17,583
AND EMMA MONTGOMERY IS IN OUR

789
00:32:17,583 --> 00:32:19,085
DIGITAL COMMUNICATIONS -- I'M

790
00:32:19,085 --> 00:32:22,255
SORRY, WEB AND DESIGN SERVICES

791
00:32:22,255 --> 00:32:24,457
BRANCH, DIGITAL COMMUNICATIONS

792
00:32:24,457 --> 00:32:25,992
SPECIALIST, LEADING OUR WEBSITE

793
00:32:25,992 --> 00:32:26,726
DEVELOPMENT, MAINTENANCE, AND

794
00:32:26,726 --> 00:32:29,595
COMPLIANCE EFFORTS.

795
00:32:29,595 --> 00:32:31,364
SHE'S GUIDING STRATEGIC

796
00:32:31,364 --> 00:32:33,532
COORDINATION WITH WEBSITE

797
00:32:33,532 --> 00:32:35,401
STAKEHOLDERS, AND OVERSEEING WEB

798
00:32:35,401 --> 00:32:37,036
USABILITY, USER EXPERIENCE

799
00:32:37,036 --> 00:32:39,238
EFFORTS, AND SEARCH ENGINE

800
00:32:39,238 --> 00:32:40,906
OPTIMIZATION PROJECTS.

801
00:32:40,906 --> 00:32:42,742
EMMA JOINED FROM THE NATIONAL

802
00:32:42,742 --> 00:32:43,743
CRIMINAL JUSTICE ASSOCIATION,

803
00:32:43,743 --> 00:32:47,680
WHERE SHE WAS A DIGITAL CONTENT

804
00:32:47,680 --> 00:32:47,913
MANAGER.

805
00:32:47,913 --> 00:32:55,021
THANK YOU. 

806
00:32:55,021 --> 00:32:55,554
>> HELLO.

807
00:32:55,554 --> 00:32:59,825
OKAY, GREAT.

808
00:32:59,825 --> 00:33:01,460
HELLO, I'M PLEASED TO WELCOME

809
00:33:01,460 --> 00:33:04,330
DR. KELLY PRINCE TO OFFICE OF

810
00:33:04,330 --> 00:33:05,298
LEGISLATION POLICY.

811
00:33:05,298 --> 00:33:07,500
IN THIS NEW ROLE SHE'S

812
00:33:07,500 --> 00:33:08,267
SUPPORTING COORDINATION AND

813
00:33:08,267 --> 00:33:10,202
EXPANSION OF OUR COMMUNITY OF

814
00:33:10,202 --> 00:33:12,305
EXTERNAL PARTNERS, AS WELL AS

815
00:33:12,305 --> 00:33:13,939
DEVELOPING PRESENTATIONS FOR NIA

816
00:33:13,939 --> 00:33:15,841
LEADERSHIP AND SERVING AS OUR

817
00:33:15,841 --> 00:33:18,444
OFFICES LIAISON WITH DIVISION OF

818
00:33:18,444 --> 00:33:19,745
AGING BIOLOGY.

819
00:33:19,745 --> 00:33:21,280
SHE JOINS FROM AMERICAN

820
00:33:21,280 --> 00:33:23,249
ASSOCIATION FOR CANCER RESEARCH

821
00:33:23,249 --> 00:33:25,217
WHERE SHE WAS ASSOCIATE DIRECTOR

822
00:33:25,217 --> 00:33:28,287
FOR SCIENCE AND HEALTH POLICY

823
00:33:28,287 --> 00:33:31,590
AND ALSO COMPLETED POSTDOC IN

824
00:33:31,590 --> 00:33:32,658
NIA'S VERY OWN INTRAMURAL

825
00:33:32,658 --> 00:33:38,597
PROGRAM IN DR. MICHELLE EVANS'

826
00:33:38,597 --> 00:33:38,798
LAB.

827
00:33:38,798 --> 00:33:45,705
WE'RE THRILLED FOR HER TO BE

828
00:33:45,705 --> 00:33:45,938
HERE.

829
00:33:45,938 --> 00:33:48,541
>> I'D LIKE TO INTRODUCE
TO THE

830
00:33:48,541 --> 00:33:49,642
OFFICE OF PLANNING AND

831
00:33:49,642 --> 00:33:51,610
EVALUATION A SOCIAL SCIENCE

832
00:33:51,610 --> 00:33:54,680
POLICY ANALYST, DR. AARON

833
00:33:54,680 --> 00:33:56,549
OGLETREE, SUPPORTING PORTFOLIO

834
00:33:56,549 --> 00:33:56,882
ANALYSIS.

835
00:33:56,882 --> 00:33:59,952
PRIOR TO JOINING NIA AARON WAS A

836
00:33:59,952 --> 00:34:01,153
SCIENTIFIC PROGRAM MANAGER

837
00:34:01,153 --> 00:34:03,656
WITHIN NIMHD OFFICE OF SCIENCE

838
00:34:03,656 --> 00:34:04,857
POLICY, PLANNING AND REPORTING,

839
00:34:04,857 --> 00:34:09,595
HE MANAGED THE ONLINE DATA

840
00:34:09,595 --> 00:34:11,664
RESOURCE, CO-LED NIMHD ANNUAL

841
00:34:11,664 --> 00:34:13,766
PORTFOLIO ANALYSES, AND

842
00:34:13,766 --> 00:34:20,406
DEVELOPED METRICS FOR EVALUATING

843
00:34:20,406 --> 00:34:22,208
NIH-WIDE STRATEGIC PLAN, Ph.D.

844
00:34:22,208 --> 00:34:29,248
IN HUMAN DEVELOPMENT AND FAMILY 

845
00:34:29,248 --> 00:34:30,750
SCIENCE FROM VIRGINIA TECH.

846
00:34:30,750 --> 00:34:35,454
THANK YOU.

847
00:34:35,454 --> 00:34:36,422
>> GOOD MORNING, I'M HAPPY
TO

848
00:34:36,422 --> 00:34:42,128
WELCOME A NEW MEMBER OF OUR

849
00:34:42,128 --> 00:34:45,398
INTRAMURAL RESEARCH COMMUNITY AT

850
00:34:45,398 --> 00:34:52,605
NIA, AND MONIQUE WALTERS,

851
00:34:52,605 --> 00:34:53,272
INTRAMURAL SUPPORT ASSISTANT,

852
00:34:53,272 --> 00:34:55,674
PREPARE TRAVEL AND SERVE AS TIME

853
00:34:55,674 --> 00:34:57,543
KEEPER, JOIN FROM DIVISION OF

854
00:34:57,543 --> 00:35:06,218
TECHNOLOGY AND RESOURCES AT NIH.

855
00:35:06,218 --> 00:35:09,522
KENDALL VAN KUEREN-JENSEN, 

856
00:35:09,522 --> 00:35:11,390
SENIOR SCIENTIST FOR CARD,

857
00:35:11,390 --> 00:35:14,026
BRINGS EXPERTISE IN TECHNOLOGY,

858
00:35:14,026 --> 00:35:16,862
ESPECIALLY GENETIC TECHNOLOGY

859
00:35:16,862 --> 00:35:19,498
AND SINGLE CELL TECHNOLOGY, NEW

860
00:35:19,498 --> 00:35:21,801
GENOMIC APPROACH, AND WILL

861
00:35:21,801 --> 00:35:24,069
IMPLEMENT SOME OF THESE

862
00:35:24,069 --> 00:35:30,543
TECHNOLOGY CARDS TO JOIN US FROM

863
00:35:30,543 --> 00:35:31,243
PROFESSOR POSITION, T-GEN,

864
00:35:31,243 --> 00:35:32,745
COLLABORATOR WITH CITY OF HOPE

865
00:35:32,745 --> 00:35:37,016
MEDICAL CENTER IN CALIFORNIA.

866
00:35:37,016 --> 00:35:40,219
NEXT SLIDE PLEASE.

867
00:35:40,219 --> 00:35:47,860
A BIOLOGIST, ALSO THROUGH THE 

868
00:35:47,860 --> 00:35:58,337
CENTER FOR RELATED DEMENTIA,

869
00:36:00,573 --> 00:36:03,476
MOHAMMED EL ALLAM

870
00:36:03,476 --> 00:36:06,846
AREA OF CNS CELL TYPE, WAS

871
00:36:06,846 --> 00:36:10,149
CONTRACTING POSITION IN THE SAME

872
00:36:10,149 --> 00:36:12,151
GROUP AND WAS HIRED AS

873
00:36:12,151 --> 00:36:13,586
BIOLOGIST, HE WILL CONTINUE TO

874
00:36:13,586 --> 00:36:18,290
DO THE EXCEPTIONAL WORK THAT HE

875
00:36:18,290 --> 00:36:23,195
WAS ALREADY DOING.

876
00:36:23,195 --> 00:36:26,599
NEXT SLIDE, SHANNON BLACK,

877
00:36:26,599 --> 00:36:34,206
MEDICAL TECHNICIAN, JOINS US IN

878
00:36:34,206 --> 00:36:36,675
CLINICAL CORE, WAS IN THE

879
00:36:36,675 --> 00:36:37,843
HEALTHY AGING IN NEIGHBORHOODS

880
00:36:37,843 --> 00:36:41,914
OF DIVERSITY ACROSS THE LIFESPAN

881
00:36:41,914 --> 00:36:43,449
STUDY, WILL PROVIDE SUPPORT AS A

882
00:36:43,449 --> 00:36:45,651
TECHNICIAN IN THE SAME STUDY.

883
00:36:45,651 --> 00:36:53,492
THE NEXT SLIDE. 

884
00:36:53,492 --> 00:36:54,693
NEW INTRAMURAL SUPPORT ASSISTANT

885
00:36:54,693 --> 00:37:05,237
IN THE LIBRARY OF EPIDEMIOLOGY,

886
00:37:08,340 --> 00:37:11,677
JOINS FROM AMERICAN RED CROSS.

887
00:37:11,677 --> 00:37:14,613
NEXT SLIDE.

888
00:37:14,613 --> 00:37:19,351
A LAB MANAGER FROM LAB GENETIC 

889
00:37:19,351 --> 00:37:23,522
AND GENOMIC, WILL OVERSEE 

890
00:37:23,522 --> 00:37:26,125
PROCESS MANAGE A NUMBER OF

891
00:37:26,125 --> 00:37:28,761
ADMINISTRATIVE NEEDS OF STAFF,

892
00:37:28,761 --> 00:37:31,697
SHE JOINS FROM THE PROGRAM

893
00:37:31,697 --> 00:37:33,465
MANAGER II POSITION WITHIN NIH

894
00:37:33,465 --> 00:37:38,537
OFFICE OF THE DIRECTOR.

895
00:37:38,537 --> 00:37:40,339
NEXT SLIDE, AN INTRAMURAL

896
00:37:40,339 --> 00:37:43,642
SUPPORT ASSISTANT IN THE

897
00:37:43,642 --> 00:37:45,744
LABORATORY OF NEUROGENETIC, SHE

898
00:37:45,744 --> 00:37:51,216
WILL BE REALLY HANDLING A NUMBER

899
00:37:51,216 --> 00:37:56,021
OF TASKS INCLUDING TRAVEL BUT

900
00:37:56,021 --> 00:37:58,624
ALSO SOME RESPONSIBILITY THAT

901
00:37:58,624 --> 00:38:00,492
DERIVES FROM NEEDS FROM SENIOR

902
00:38:00,492 --> 00:38:01,026
MANAGEMENT.

903
00:38:01,026 --> 00:38:05,297
SHE WAS PREVIOUSLY A DENTAL

904
00:38:05,297 --> 00:38:07,399
HYGIENIST WITH THE VIRGINIA/DC

905
00:38:07,399 --> 00:38:08,801
AREA.

906
00:38:08,801 --> 00:38:12,738
NEXT SLIDE. 

907
00:38:12,738 --> 00:38:16,108
AND THE PROJECT SPECIALIST,

908
00:38:16,108 --> 00:38:18,444
COMPUTER TECHNOLOGY SECTION, WAS

909
00:38:18,444 --> 00:38:21,981
PREVIOUSLY A PROGRAM SPECIALIST

910
00:38:21,981 --> 00:38:23,816
AT OFFICE OF UNITED STATES

911
00:38:23,816 --> 00:38:25,651
COURTS, BRINGS NEW IDEAS, NEW

912
00:38:25,651 --> 00:38:30,456
TECHNOLOGY IN I.T. AND SHE WILL

913
00:38:30,456 --> 00:38:34,526
BE ALSO WORKENING ON THE

914
00:38:34,526 --> 00:38:44,269
DEVELOPMENT A.I. TECHNOLOGY. 

915
00:38:44,269 --> 00:38:49,642
NEXT SLIDE. 

916
00:38:49,642 --> 00:38:52,411
GERONTOLOGY BRANCH, JOINS FROM

917
00:38:52,411 --> 00:38:53,846
THE TEXAS SOUTHWESTERN MEDICAL

918
00:38:53,846 --> 00:38:58,651
CENTER, VICTORIA IS BECOMING A

919
00:38:58,651 --> 00:39:00,953
WORLD EXPERT IN CIRCADIAN

920
00:39:00,953 --> 00:39:02,655
BIOLOGY, EMERGING IN AGING

921
00:39:02,655 --> 00:39:02,888
BIOLOGY.

922
00:39:02,888 --> 00:39:07,393
I CAN TELL YOU YESTERDAY WAS

923
00:39:07,393 --> 00:39:08,594
NOMINATED DISTINGUISHED SCHOLAR,

924
00:39:08,594 --> 00:39:11,530
BIG HONOR AT NIH, ALSO COMES

925
00:39:11,530 --> 00:39:13,732
WITH, YOU KNOW, FUNDING THAT

926
00:39:13,732 --> 00:39:16,135
WILL BE, YOU KNOW, CONSIDERABLE

927
00:39:16,135 --> 00:39:19,972
FUNDING IN THE FIRST FIVE YEARS,

928
00:39:19,972 --> 00:39:23,809
WILL HELP HER IN REALLY BUILDING

929
00:39:23,809 --> 00:39:25,177
HER LAB AND STRENGTHENING THE

930
00:39:25,177 --> 00:39:27,079
SCIENCE SHE'S DOING.

931
00:39:27,079 --> 00:39:29,948
I THINK THIS WAS MY LAST SLIDE

932
00:39:29,948 --> 00:39:34,653
FROM THAT ROUND.

933
00:39:34,653 --> 00:39:34,853
YES.

934
00:39:34,853 --> 00:39:36,855
>> THANK YOU, I HOPE YOU
WERE

935
00:39:36,855 --> 00:39:38,724
INFORMED AND IMPRESSED BY THE

936
00:39:38,724 --> 00:39:41,026
SCOPE AND TALENT THAT WE ARE

937
00:39:41,026 --> 00:39:41,760
BRINGING TO THE INSTITUTE, MUCH

938
00:39:41,760 --> 00:39:46,799
NEEDED AS WE GROW AND OUR 

939
00:39:46,799 --> 00:39:48,000
MISSION EXPANDS.

940
00:39:48,000 --> 00:39:49,234
FINALLY, EMPHASIZING OUR HOPE

941
00:39:49,234 --> 00:39:51,303
YOU'LL STAY ENGAGED WITH US

942
00:39:51,303 --> 00:39:52,438
BETWEEN COUNCIL MEETINGS.

943
00:39:52,438 --> 00:40:00,512
THESE ARE SOME OF THE MANY SITES

944
00:40:00,512 --> 00:40:01,213
AND OPPORTUNITIES.

945
00:40:01,213 --> 00:40:03,215
IF YOU'RE NOT ON PRO-ACTIVE

946
00:40:03,215 --> 00:40:04,383
MAILING LISTS, LET US KNOW AND

947
00:40:04,383 --> 00:40:07,486
WE'LL MAKE SURE YOU ARE.

948
00:40:07,486 --> 00:40:08,053
THANK YOU.

949
00:40:08,053 --> 00:40:09,788
KEN, BACK TO YOU.

950
00:40:09,788 --> 00:40:11,757
>> ALL RIGHT.

951
00:40:11,757 --> 00:40:15,494
WE CAN OPEN UP FOR QUESTIONS FOR

952
00:40:15,494 --> 00:40:16,695
DR. HODES.

953
00:40:16,695 --> 00:40:22,601
FOR ALL THE UPDATES AND BUDGET

954
00:40:22,601 --> 00:40:25,437
AND ANY OTHER ISSUES YOU MAY

955
00:40:25,437 --> 00:40:25,637
HAVE.

956
00:40:25,637 --> 00:40:27,072
>> THAT'S REALLY
IMPRESSIVE TO

957
00:40:27,072 --> 00:40:28,507
SEE THIS GROUP OF PEOPLE

958
00:40:28,507 --> 00:40:28,941
JOINING.

959
00:40:28,941 --> 00:40:34,313
THANK YOU FOR THE UPDATE.

960
00:40:34,313 --> 00:40:35,180
THIS IS -- THIS REMINDED ME I'VE

961
00:40:35,180 --> 00:40:37,483
BEEN MEANING TO ASK YOU THIS

962
00:40:37,483 --> 00:40:37,750
QUESTION.

963
00:40:37,750 --> 00:40:39,785
WITH COMMUNICATIONS, SOMETHING

964
00:40:39,785 --> 00:40:43,088
AS LARGE AS A $4 BILLION

965
00:40:43,088 --> 00:40:44,723
OPERATION, ARE THERE METRICS YOU

966
00:40:44,723 --> 00:40:46,692
KEEP TRACK OF, OF HOW MANY

967
00:40:46,692 --> 00:40:50,195
PEOPLE ARE ACTUALLY LOOKING AT

968
00:40:50,195 --> 00:40:54,233
THE BLOGS OR LOOKING AT JOINING?

969
00:40:54,233 --> 00:40:55,067
BECAUSE IT SEEMS THAT WOULD BE

970
00:40:55,067 --> 00:40:57,236
PRETTY IMPORTANT WHETHER OR NOT

971
00:40:57,236 --> 00:40:59,471
IT'S REACHING PEOPLE AT A LEVEL

972
00:40:59,471 --> 00:41:02,441
THAT YOU THINK WOULD BE

973
00:41:02,441 --> 00:41:02,741
SUCCESSFUL.

974
00:41:02,741 --> 00:41:03,208
>> GREAT POINT.

975
00:41:03,208 --> 00:41:04,610
GREAT QUESTION.

976
00:41:04,610 --> 00:41:05,611
THE ANSWER IS YES.

977
00:41:05,611 --> 00:41:07,479
WE CAN IN THE FUTURE PROVIDE

978
00:41:07,479 --> 00:41:08,080
THOSE.

979
00:41:08,080 --> 00:41:09,114
IN FACT WE CAN FOLLOW UP IN THE

980
00:41:09,114 --> 00:41:10,315
SHORT TERM.

981
00:41:10,315 --> 00:41:12,184
I KNOW CINDY IS ON.

982
00:41:12,184 --> 00:41:14,153
>> YES, I AM.

983
00:41:14,153 --> 00:41:17,756
YES, WE ABSOLUTELY VERY

984
00:41:17,756 --> 00:41:18,957
CAREFULLY MONITOR ANALYTICS,

985
00:41:18,957 --> 00:41:19,825
MONITORING THOSE AND ANALYZING

986
00:41:19,825 --> 00:41:24,096
THOSE ARE A BIG PART OF HOW WE

987
00:41:24,096 --> 00:41:24,563
CONDUCT OUR STRATEGIC

988
00:41:24,563 --> 00:41:25,330
COMMUNICATIONS PLANNING.

989
00:41:25,330 --> 00:41:27,733
AND I WOULD BE MORE THAN HAPPY

990
00:41:27,733 --> 00:41:32,004
IN THE FUTURE TO PROVIDE SOME OF

991
00:41:32,004 --> 00:41:34,506
THOSE ANALYTICS.

992
00:41:34,506 --> 00:41:36,175
>> THANK YOU, CINDY.

993
00:41:36,175 --> 00:41:37,943
WE DON'T NEED TO WAIT TILL NEXT

994
00:41:37,943 --> 00:41:38,177
COUNCIL.

995
00:41:38,177 --> 00:41:38,911
WE CAN PUT SOMETHING TOGETHER

996
00:41:38,911 --> 00:41:41,413
AND SEND IT OUT TO COUNCIL

997
00:41:41,413 --> 00:41:41,914
MEMBERS.

998
00:41:41,914 --> 00:41:42,281
>> ABSOLUTELY.

999
00:41:42,281 --> 00:41:44,583
>> THANKS, CINDY.

1000
00:41:44,583 --> 00:41:48,520
 

1001
00:41:48,520 --> 00:41:48,654
 

1002
00:41:48,654 --> 00:41:59,031
>> [OFF MICROPHONE]

1003
00:42:27,125 --> 00:42:37,269
(INAUDIBLE ]

1004
00:43:38,163 --> 00:43:48,140
 

1005
00:43:56,782 --> 00:43:59,885
THAT INFORMATION THAT COMES FROM

1006
00:43:59,885 --> 00:44:00,085
NIA --

1007
00:44:00,085 --> 00:44:01,954
>> THANK YOU SO MUCH FOR
THE

1008
00:44:01,954 --> 00:44:03,388
COMMENT AND SUGGESTION.

1009
00:44:03,388 --> 00:44:05,557
MAYBE WE CAN ASK YOUR HELP IN

1010
00:44:05,557 --> 00:44:06,892
UNDERSTANDING WHICH IF NOT ALL

1011
00:44:06,892 --> 00:44:08,727
OF THE COMMUNICATIONS WE PUT

1012
00:44:08,727 --> 00:44:10,929
FORWARD CAN BE DISTRIBUTED AND

1013
00:44:10,929 --> 00:44:12,898
YOUR HELP IN SHARING WHAT YOU

1014
00:44:12,898 --> 00:44:18,670
THINK ARE THE BEST E-MAIL

1015
00:44:18,670 --> 00:44:22,407
RECIPIENT LISTS.

1016
00:44:22,407 --> 00:44:24,142
>> ABSOLUTELY.

1017
00:44:24,142 --> 00:44:24,743
>> AMERICAN ASSOCIATION OF

1018
00:44:24,743 --> 00:44:25,377
PHYSICIAN, NATIONAL INDIAN

1019
00:44:25,377 --> 00:44:27,980
HEALTH BOARD, I WOULD START WITH

1020
00:44:27,980 --> 00:44:28,981
INDIAN HEALTH SERVICE, SO THERE

1021
00:44:28,981 --> 00:44:38,824
ARE A NUMBER OF PLACES.

1022
00:44:38,824 --> 00:44:40,125
CARINA WALTER IS A GREAT

1023
00:44:40,125 --> 00:44:41,760
RESOURCE, CAN TELL YOU MORE.

1024
00:44:41,760 --> 00:44:43,428
IN ADDITION TO SENDING

1025
00:44:43,428 --> 00:44:45,998
INFORMATION TO ACADEMIA, YOU

1026
00:44:45,998 --> 00:44:47,132
KNOW, TRAVEL CONSUMER I THINK

1027
00:44:47,132 --> 00:44:49,868
WOULD BE A GREAT PLACE TO GO.

1028
00:44:49,868 --> 00:44:51,470
INFORMATION IS REALLY AWESOME.

1029
00:44:51,470 --> 00:44:52,170
>> GREAT SUGGESTION.

1030
00:44:52,170 --> 00:44:52,738
THANK YOU.

1031
00:44:52,738 --> 00:44:57,876
WE'LL FOLLOW UP.

1032
00:44:57,876 --> 00:44:58,176
>> THANKS.

1033
00:44:58,176 --> 00:44:59,211
>> THANKS FOR THE REPORT.

1034
00:44:59,211 --> 00:45:02,381
YOU MENTIONED A CAPITOL HILL

1035
00:45:02,381 --> 00:45:03,248
BRIEFING TOMORROW.

1036
00:45:03,248 --> 00:45:05,017
IS IT TOMORROW?

1037
00:45:05,017 --> 00:45:05,283
>> YES.

1038
00:45:05,283 --> 00:45:08,320
IT'S A HEARING, NOT BRIEFING.

1039
00:45:08,320 --> 00:45:12,691
DISTINCTION IS MAYBE LOST ON YOU

1040
00:45:12,691 --> 00:45:15,293
BUT NOT ON US.

1041
00:45:15,293 --> 00:45:17,262
>> WHAT TIME?

1042
00:45:17,262 --> 00:45:19,598
>> I BELIEVE IT STARTS AT
10:00.

1043
00:45:19,598 --> 00:45:21,333
>> IS IT OPEN TO THE
PUBLIC?

1044
00:45:21,333 --> 00:45:22,634
>> IT IS.

1045
00:45:22,634 --> 00:45:26,138
IN FACT, WE CAN SEND YOU ALL

1046
00:45:26,138 --> 00:45:34,246
INFORMATION. 

1047
00:45:34,246 --> 00:45:39,718
 

1048
00:45:39,718 --> 00:45:41,253
THE HEARING, A GROUP OF US WILL

1049
00:45:41,253 --> 00:45:44,089
BE LEAVING FROM NIH AT 7:55 TO

1050
00:45:44,089 --> 00:45:50,028
MAKE SURE WE'RE THERE IN TIME.

1051
00:45:50,028 --> 00:45:51,563
>> RICHARD, A COUPLE
POINTS.

1052
00:45:51,563 --> 00:45:54,399
IN TERMS OF THE MONEY THAT YOU

1053
00:45:54,399 --> 00:45:56,835
GOT FOR PALLIATIVE CARE, I

1054
00:45:56,835 --> 00:45:58,336
ASSUME A LOT -- IS IT FOR MOST

1055
00:45:58,336 --> 00:46:02,174
OF THE MAJOR DISEASES OR IS IT

1056
00:46:02,174 --> 00:46:05,477
FOCUSED TOWARD ADRD?

1057
00:46:05,477 --> 00:46:06,278
>> GREAT QUESTION.

1058
00:46:06,278 --> 00:46:07,546
IT'S BROAD SPECIFICALLY IN THE

1059
00:46:07,546 --> 00:46:09,481
LANGUAGE THAT COMES WITH THIS

1060
00:46:09,481 --> 00:46:11,750
FUNDING, IN THIS FISCAL YEAR FOR

1061
00:46:11,750 --> 00:46:14,753
PALLIATIVE CARE, TARGETED AT THE

1062
00:46:14,753 --> 00:46:19,891
ESTABLISHMENT OF PALLIATIVE CARE

1063
00:46:19,891 --> 00:46:22,327
 CONSORTIUM OF AT LEASE THREE

1064
00:46:22,327 --> 00:46:23,829
SITES TO COORDINATE EFFORTS

1065
00:46:23,829 --> 00:46:24,262
ACROSS NIH.

1066
00:46:24,262 --> 00:46:31,470
NIA HAS BEEN DESIGNATED TO LEAD,

1067
00:46:31,470 --> 00:46:35,640
AMY KELLEY HAS BEEN A LEADER

1068
00:46:35,640 --> 00:46:36,741
ACROSS INSTITUTES AND DISEASE

1069
00:46:36,741 --> 00:46:38,677
ORIENTATION AS WELL AS LIFE

1070
00:46:38,677 --> 00:46:40,879
COURSE ORIENTATION, MAKE THIS A

1071
00:46:40,879 --> 00:46:42,447
VERY BROAD EFFORT WITH NIA

1072
00:46:42,447 --> 00:46:46,151
TAKING A LEAD, BY NO MEANS THE

1073
00:46:46,151 --> 00:46:48,553
WHOLE PARTICIPANT.

1074
00:46:48,553 --> 00:46:49,821
>> THE OTHER THING WAS IN
THE

1075
00:46:49,821 --> 00:46:52,724
AREA OF REAL WORLD DATA, REAL

1076
00:46:52,724 --> 00:46:55,327
WORLD EVIDENCE RESEARCH, I SAW

1077
00:46:55,327 --> 00:46:56,761
SOME INFORMATION THERE THAT

1078
00:46:56,761 --> 00:46:58,096
PERHAPS YOU RECRUITED SOME

1079
00:46:58,096 --> 00:46:59,965
PEOPLE IN THAT AREA TO DEAL WITH

1080
00:46:59,965 --> 00:47:00,365
THAT DATA.

1081
00:47:00,365 --> 00:47:05,403
AND OF COURSE WE HEARD FROM THE

1082
00:47:05,403 --> 00:47:08,373
FDA COMMISSIONER, THE MOST

1083
00:47:08,373 --> 00:47:10,775
RECENT MEETING, FOCUSED IN THAT

1084
00:47:10,775 --> 00:47:12,410
AREA, WONDER IF YOU COULD SHARE

1085
00:47:12,410 --> 00:47:13,945
SOME PLANS ABOUT EXPANSION OF

1086
00:47:13,945 --> 00:47:16,148
WORK IN THAT AREA AND WHETHER

1087
00:47:16,148 --> 00:47:18,416
THERE COULD BE COLLABORATION

1088
00:47:18,416 --> 00:47:21,620
WITH FDA ON THAT SIDE.

1089
00:47:21,620 --> 00:47:21,987
>> ABSOLUTELY.

1090
00:47:21,987 --> 00:47:24,689
REAL WORLD DATA AND RESEARCH

1091
00:47:24,689 --> 00:47:26,758
USING REAL WORLD DATA CRITICAL

1092
00:47:26,758 --> 00:47:30,595
TO OUR EFFORTS TO UNDERSTAND AN

1093
00:47:30,595 --> 00:47:34,966
INCLIVE  INCLUSIVE AND

1094
00:47:34,966 --> 00:47:36,201
COMPREHENSIVE, TO WORK TOWARD

1095
00:47:36,201 --> 00:47:38,803
THE AIM OF THE OPTIMIZING

1096
00:47:38,803 --> 00:47:39,037
HEALTH.

1097
00:47:39,037 --> 00:47:41,540
THERE HAVE BEEN A NUMBER OF REAL

1098
00:47:41,540 --> 00:47:46,011
WORLD DATA INITIATIVES THAT NIA

1099
00:47:46,011 --> 00:47:47,646
SUPPORTED ALREADY, REMARKABLY

1100
00:47:47,646 --> 00:47:50,715
EFFECTIVE, INCLUDED THINGS LIKE

1101
00:47:50,715 --> 00:47:53,218
THE IMPACT COLLABORATORY,

1102
00:47:53,218 --> 00:47:55,987
WORKING THROUGH THE NIH HEALTH

1103
00:47:55,987 --> 00:47:56,755
SERVICES COLLABORATORY, AND

1104
00:47:56,755 --> 00:47:58,490
INTENT CERTAINLY TO CONTINUE

1105
00:47:58,490 --> 00:48:00,192
THESE EFFORTS BUT IMPORTANTLY TO

1106
00:48:00,192 --> 00:48:04,396
BE DOING THESE IN THE CONTEXT OF

1107
00:48:04,396 --> 00:48:06,598
THE INCREASED NUMBER OF

1108
00:48:06,598 --> 00:48:08,667
EXTENSIVE LARGE DATA EFFORTS

1109
00:48:08,667 --> 00:48:10,202
THAT ARE NOW NIH-WIDE AND

1110
00:48:10,202 --> 00:48:10,936
DEPARTMENT-WIDE.

1111
00:48:10,936 --> 00:48:12,737
SO PART OF THE ANSWER TO THE

1112
00:48:12,737 --> 00:48:18,743
SPECIFIC QUESTION, WE INTEND TO

1113
00:48:18,743 --> 00:48:21,813
CONTINUE THESE AREAS CLOSE

1114
00:48:21,813 --> 00:48:22,447
CONSULTATION WITH LEADERSHIP FOR

1115
00:48:22,447 --> 00:48:25,016
OFFICE OF DATA SCIENCE AND NIH

1116
00:48:25,016 --> 00:48:25,750
AND WITH MONICA BERTAGNOLLI

1117
00:48:25,750 --> 00:48:27,219
HERSELF BECAUSE THIS IS AN AREA

1118
00:48:27,219 --> 00:48:28,520
OF INTEREST TO HER.

1119
00:48:28,520 --> 00:48:29,721
WE'RE GOING FORWARD IN THIS

1120
00:48:29,721 --> 00:48:32,023
AREA, HOPE TO DO OUR BEST TO

1121
00:48:32,023 --> 00:48:34,826
OPTIMIZE WHAT WE'RE DOING AND

1122
00:48:34,826 --> 00:48:38,930
CONTRIBUTING IN PART TO THE NIH,

1123
00:48:38,930 --> 00:48:39,731
HHS, FEDERAL GOVERNMENT-WIDE

1124
00:48:39,731 --> 00:48:43,068
EFFORTS IN THIS IMPORTANT AREA.

1125
00:48:43,068 --> 00:48:49,307
>> THANK YOU.

1126
00:48:49,307 --> 00:48:51,176
>> ANY OTHER QUESTIONS?

1127
00:48:51,176 --> 00:48:54,879
>> THIS IS BIG PICTURE
QUESTION.

1128
00:48:54,879 --> 00:48:57,115
IN TERMS OF -- I DON'T KNOW MUCH

1129
00:48:57,115 --> 00:49:04,556
ABOUT THE AREA, BUT I KNOW SOME

1130
00:49:04,556 --> 00:49:05,257
ASPECT, THERAPEUTIC AREA --

1131
00:49:05,257 --> 00:49:15,500
(INAUDIBLE). 

1132
00:49:24,442 --> 00:49:25,410
NOW IT'S ON.

1133
00:49:25,410 --> 00:49:30,415
THANK YOU. 

1134
00:49:30,415 --> 00:49:32,050
WONDERING ABOUT ENGAGEMENT WITH

1135
00:49:32,050 --> 00:49:35,553
FDA AND THERAPEUTIC CONTEXT OF

1136
00:49:35,553 --> 00:49:37,289
AGING, WHAT'S AMENABLE TO

1137
00:49:37,289 --> 00:49:39,591
THERAPEUTICS, WHAT'S NOT, MAYBE

1138
00:49:39,591 --> 00:49:41,126
EVERYTHING IS.

1139
00:49:41,126 --> 00:49:43,862
YOU KNOW, IS THERE A SPECTRUM

1140
00:49:43,862 --> 00:49:46,831
LIKE SARCOPENIA I GUESS COULD BE

1141
00:49:46,831 --> 00:49:47,632
THERAPEUTICALLY TREATED, DRUGS

1142
00:49:47,632 --> 00:49:50,235
COULD BE DEVELOPED FOR THAT IF

1143
00:49:50,235 --> 00:49:53,738
THAT'S POSSIBLE AS MECHANISMS

1144
00:49:53,738 --> 00:49:55,607
ARE ELUCIDATED.

1145
00:49:55,607 --> 00:49:56,241
AGE-ASSOCIATED COGNITIVE CHANGES

1146
00:49:56,241 --> 00:49:58,076
IS NOT A DISEASE SO THERE'S NO

1147
00:49:58,076 --> 00:49:59,110
TREATMENT STRATEGY, I DON'T KNOW

1148
00:49:59,110 --> 00:50:00,512
IF THAT'S TRUE, DO YOU GET

1149
00:50:00,512 --> 00:50:02,614
INVOLVED IN THAT BIG PICTURE

1150
00:50:02,614 --> 00:50:04,049
THERAPEUTICS AND AGING?

1151
00:50:04,049 --> 00:50:05,317
>> THANKS FOR THAT
QUESTION.

1152
00:50:05,317 --> 00:50:07,752
OVER THE YEARS WE'VE HAD

1153
00:50:07,752 --> 00:50:09,721
MULTIPLE MEETINGS WITH STAFF

1154
00:50:09,721 --> 00:50:11,690
FROM FDA, TO DISCUSS THESE KINDS

1155
00:50:11,690 --> 00:50:12,657
OF QUESTIONS.

1156
00:50:12,657 --> 00:50:14,426
MY OWN SENSE IS OVERALL THEY

1157
00:50:14,426 --> 00:50:19,230
HAVE BEEN VERY RECEPTIVE AND

1158
00:50:19,230 --> 00:50:20,665
UNDERSTANDING FOR OUTCOMES

1159
00:50:20,665 --> 00:50:21,733
CLINICALLY MEANINGFUL, WHETHER

1160
00:50:21,733 --> 00:50:24,135
DISEASE SPECIFIC OR BROADER IN

1161
00:50:24,135 --> 00:50:27,639
THEIR DETERMINATION, THEY ARE

1162
00:50:27,639 --> 00:50:29,074
OPEN AND RECEPTIVE AND THEY

1163
00:50:29,074 --> 00:50:32,777
PUBLISHED THEIR GUIDELINES WHICH

1164
00:50:32,777 --> 00:50:33,111
WE'VE SHARED.

1165
00:50:33,111 --> 00:50:39,050
HAPPY TO SHARE FURTHER WITH YOU

1166
00:50:39,050 --> 00:50:40,885
THE CONVERSATIONS WE'VE HAD.

1167
00:50:40,885 --> 00:50:42,220
THERE HAVE BEEN THOSE THAT FOUND

1168
00:50:42,220 --> 00:50:43,621
IT DIFFICULT TO FIND A HOME AT

1169
00:50:43,621 --> 00:50:50,095
FDA BECAUSE WHAT WE DEAL WITH IS

1170
00:50:50,095 --> 00:50:50,895
SO BROAD.

1171
00:50:50,895 --> 00:50:54,899
WE'VE HAD GROUPS REPRESENTING

1172
00:50:54,899 --> 00:50:57,769
DISCIPLINES, ENDOCRINOLOGY,

1173
00:50:57,769 --> 00:50:58,970
MUSCULOSKELETAL, AS A WHOLE,

1174
00:50:58,970 --> 00:51:00,271
RECEPTIVE TO PROPOSALS WITH

1175
00:51:00,271 --> 00:51:01,706
MEANINGFUL OUTCOMES TO THEY ARE

1176
00:51:01,706 --> 00:51:04,008
MUTICS WITHOUT BEING BOUND BY

1177
00:51:04,008 --> 00:51:05,844
LABELS, PER SE.

1178
00:51:05,844 --> 00:51:06,644
IT'S FRUSTRATING, HASN'T BEEN

1179
00:51:06,644 --> 00:51:08,179
EASY BUT YES WE'VE BEEN AND WILL

1180
00:51:08,179 --> 00:51:13,184
CONTINUE TO BE ENGAGED WITH

1181
00:51:13,184 --> 00:51:13,385
THEM.

1182
00:51:13,385 --> 00:51:14,352
>> THERAPEUTIC DOESN'T
HAVE TO

1183
00:51:14,352 --> 00:51:17,222
BE ANCHORED BY A DISEASE PER SE.

1184
00:51:17,222 --> 00:51:18,123
IT'S CLINICAL MEANINGFULNESS, I

1185
00:51:18,123 --> 00:51:23,361
IMAGINE WITH THAT IS QUALITY OF

1186
00:51:23,361 --> 00:51:24,129
LIFE.

1187
00:51:24,129 --> 00:51:25,463
>> YES, AGAIN, THESE ARE

1188
00:51:25,463 --> 00:51:26,965
ANECDOTAL CONVERSATIONS WE'VE

1189
00:51:26,965 --> 00:51:27,132
HAD.

1190
00:51:27,132 --> 00:51:31,569
BUT THAT'S BEEN VERY MUCH THE

1191
00:51:31,569 --> 00:51:31,936
EMPHASIS.

1192
00:51:31,936 --> 00:51:35,073
CLINICALLY MEANINGFUL OUTCOMES

1193
00:51:35,073 --> 00:51:36,875
THAT CAN BE MEASURED,

1194
00:51:36,875 --> 00:51:39,110
QUANTIFIED, IN SUCH A WAY THAT

1195
00:51:39,110 --> 00:51:40,545
PROVIDES EVIDENCE BASE FOR

1196
00:51:40,545 --> 00:51:42,514
APPROVAL OF INTERVENTIONS.

1197
00:51:42,514 --> 00:51:44,282
THEY ARE OPEN TO THIS.

1198
00:51:44,282 --> 00:51:45,683
>> THAT'S GOOD TO KNOW.

1199
00:51:45,683 --> 00:51:48,086
THANK YOU.

1200
00:51:48,086 --> 00:51:50,155
>> I DON'T KNOW IF -- EVAN

1201
00:51:50,155 --> 00:51:51,589
HADLEY, IF YOU'RE ON, HE'S BEEN

1202
00:51:51,589 --> 00:51:52,991
PART OF THE CONVERSATIONS.

1203
00:51:52,991 --> 00:51:54,659
DID YOU WANT TO AMPLIFY ON THAT

1204
00:51:54,659 --> 00:51:56,628
AT ALL?

1205
00:51:56,628 --> 00:51:59,330
SORRY TO PUT YOU ON THE SPOT,

1206
00:51:59,330 --> 00:52:00,765
NOT SURE EVAN WAS ABLE TO STAY

1207
00:52:00,765 --> 00:52:03,968
ON.

1208
00:52:03,968 --> 00:52:05,804
>> I THINK IT'S GREAT YOU
HAVE

1209
00:52:05,804 --> 00:52:08,573
THAT ONGOING ENGAGEMENT WITH THE

1210
00:52:08,573 --> 00:52:08,740
FDA.

1211
00:52:08,740 --> 00:52:10,542
I THINK THE NIA IS A KEY

1212
00:52:10,542 --> 00:52:14,646
IMPORTANT PART OF THAT.

1213
00:52:14,646 --> 00:52:24,222
 

1214
00:52:24,222 --> 00:52:25,323
>> RICHARD, ANY PROGNOSIS

1215
00:52:25,323 --> 00:52:30,028
WHETHER FDA IS GOING TO ADOPT 

1216
00:52:30,028 --> 00:52:32,430
ANY OF THE ACROSS-THE-LIFESPAN

1217
00:52:32,430 --> 00:52:41,873
APPROACHES TO RESEARCH THAT NI A

1218
00:52:41,873 --> 00:52:42,841
AND NIH HAVE ADOPTED?

1219
00:52:42,841 --> 00:52:44,275
I HAVEN'T SEEN ANYTHING ON THAT

1220
00:52:44,275 --> 00:52:45,343
FRONT, I WATCH CLOSELY.

1221
00:52:45,343 --> 00:52:48,179
THEY REALLY HAVE SORT OF BEEN

1222
00:52:48,179 --> 00:52:52,016
DRAGGING THEIR HEELS ON THE IDEA

1223
00:52:52,016 --> 00:52:54,652
THAT RESEARCH SHOULD REPRESENT

1224
00:52:54,652 --> 00:52:56,187
THE SPECTRUM OF OUR LIFESPAN AND

1225
00:52:56,187 --> 00:53:02,327
NOT SORT OF HAVE THESE CUTOFFS,

1226
00:53:02,327 --> 00:53:04,596
AGE-BASED CUTOFFS.

1227
00:53:04,596 --> 00:53:10,168
>> I THINK THE QUESTION
ABOUT

1228
00:53:10,168 --> 00:53:11,135
CUTOFFS ACTIVITY, AGE

1229
00:53:11,135 --> 00:53:13,905
SPECIFICITY IN RESEARCH IS

1230
00:53:13,905 --> 00:53:15,406
REALLY -- IS NOT FDA PURSUE SO

1231
00:53:15,406 --> 00:53:15,974
MUCH AS NIH.

1232
00:53:15,974 --> 00:53:20,245
IF THE QUESTION IS DIRECTED TO

1233
00:53:20,245 --> 00:53:26,985
WHETHER FDA SHOULD INSIST ON AGE

1234
00:53:26,985 --> 00:53:28,887
INCLUSION, I THINK, YOU KNOW,

1235
00:53:28,887 --> 00:53:30,755
THE SEPARATE AGENCY, I DON'T

1236
00:53:30,755 --> 00:53:31,723
HAVE ANY FURTHER INSIGHTS WHAT

1237
00:53:31,723 --> 00:53:33,925
THEY ARE DOING BUT I THINK I

1238
00:53:33,925 --> 00:53:37,295
WANT TO EMPHASIZE RESPONSIBILITY

1239
00:53:37,295 --> 00:53:41,666
WE ARE IN THIS REGARD, AND

1240
00:53:41,666 --> 00:53:44,736
THERE'S A LONG HISTORY OF

1241
00:53:44,736 --> 00:53:45,837
EXCLUSION BY AIMING WITHOUT

1242
00:53:45,837 --> 00:53:47,939
JUSTIFICATION OR PURPOSE, AND

1243
00:53:47,939 --> 00:53:49,107
IT'S CLEARLY INTOLERABLE.

1244
00:53:49,107 --> 00:53:50,642
I CAN SHARE CONVERSATIONS I'VE

1245
00:53:50,642 --> 00:53:54,012
HAD WITH LEADERS OF OTHER

1246
00:53:54,012 --> 00:53:55,213
INSTITUTES, FOR EXAMPLE, ABOUT

1247
00:53:55,213 --> 00:53:56,548
SOME OF THE SUBTLETIES.

1248
00:53:56,548 --> 00:53:58,950
SO INCLUSION ACROSS THE AGE

1249
00:53:58,950 --> 00:54:02,654
RANGE WITHOUT LIMITS IN EVERY

1250
00:54:02,654 --> 00:54:06,624
STUDY IS ONE SUGGESTION.

1251
00:54:06,624 --> 00:54:08,626
BUT THERE ARE SUBTLETIES OR

1252
00:54:08,626 --> 00:54:11,429
SPECIFICATIONS RAISED, FOR

1253
00:54:11,429 --> 00:54:14,966
EXAMPLE IN CONDUCT FOR

1254
00:54:14,966 --> 00:54:15,900
CROSS-SECTIONAL STUDY MAYBE

1255
00:54:15,900 --> 00:54:17,235
NOTABLE BUT FOR LONGITUDINAL

1256
00:54:17,235 --> 00:54:19,103
STUDIES THERE ARE THOSE CASES

1257
00:54:19,103 --> 00:54:21,205
WHICH THE ARGUMENT HAS BEEN MADE

1258
00:54:21,205 --> 00:54:26,144
THAT BEGINNING AT EARLIER AGE

1259
00:54:26,144 --> 00:54:27,645
BEFORE OVERT PATHOLOGY AND BEING

1260
00:54:27,645 --> 00:54:29,314
COMMITTED TO LONGITUDINAL STUDY

1261
00:54:29,314 --> 00:54:31,082
INTO OLDER AGE IS THE MOST

1262
00:54:31,082 --> 00:54:33,818
EFFECTIVE COST EFFICIENT AS WELL

1263
00:54:33,818 --> 00:54:39,324
RESEARCH STRATEGY TO ENGAGE OVER

1264
00:54:39,324 --> 00:54:40,291
LIFESPAN.

1265
00:54:40,291 --> 00:54:42,026
OUR HACKLES GO UP TOO, AGE

1266
00:54:42,026 --> 00:54:45,430
CUTOFF AT X.

1267
00:54:45,430 --> 00:54:48,366
BUT LOOKING RIGOROUSLY AT WHAT

1268
00:54:48,366 --> 00:54:50,268
THE JUSTIFICATION MAY BE, WE'RE

1269
00:54:50,268 --> 00:54:52,637
OPEN TO WHAT OPTIMIZES IN THE

1270
00:54:52,637 --> 00:54:55,173
END RESEARCH THAT WILL INFORM

1271
00:54:55,173 --> 00:54:56,341
WHAT THE BEST APPROACHES,

1272
00:54:56,341 --> 00:54:58,443
CONDITIONS TO AFFECT PEOPLE IN

1273
00:54:58,443 --> 00:55:00,211
OLDER AGE.

1274
00:55:00,211 --> 00:55:02,080
YOUR QUESTION WAS WITH RESPECT

1275
00:55:02,080 --> 00:55:06,651
TO FDA AND THEIR APPROVAL.

1276
00:55:06,651 --> 00:55:07,852
WHETHER FOR INDICATIONS OF A

1277
00:55:07,852 --> 00:55:10,154
THERAPY AT A GIVEN AGE RANGE,

1278
00:55:10,154 --> 00:55:11,689
THEY ARE WILLING TO APPROVE IF

1279
00:55:11,689 --> 00:55:13,858
THAT'S WHERE THE RESEARCH LIES,

1280
00:55:13,858 --> 00:55:16,728
I DON'T KNOW IF IT'S SO MUCH

1281
00:55:16,728 --> 00:55:17,829
REGULATORY ROLE TO SAY WE WON'T

1282
00:55:17,829 --> 00:55:20,765
ACCEPT AS FOR US TO PROVIDE

1283
00:55:20,765 --> 00:55:23,701
SUPPORT, THE RESEARCH, WHICH

1284
00:55:23,701 --> 00:55:28,306
WILL LEAD THEM IN THE FDA

1285
00:55:28,306 --> 00:55:28,940
APPROVALS SPECIFYING ELIGIBILITY

1286
00:55:28,940 --> 00:55:34,579
TO HAVE THE AGE BASIS FOR THEIR

1287
00:55:34,579 --> 00:55:39,817
RECOMMENDATIONS. 

1288
00:55:39,817 --> 00:55:43,655
>> I RECOGNIZE THERE
DIFFERENT

1289
00:55:43,655 --> 00:55:45,390
AGENCY AND APPRECIATE WHAT NIH

1290
00:55:45,390 --> 00:55:54,699
HAS DONE WITH THE LEADERSHIP OF

1291
00:55:54,699 --> 00:55:56,534
NIA AND THE FOLKS, INSTITUTES

1292
00:55:56,534 --> 00:55:58,736
AND POLICIES THAT PLACE EMPHASIS

1293
00:55:58,736 --> 00:56:00,905
ON THE LIFESPAN, AGE SPAN, AS

1294
00:56:00,905 --> 00:56:01,906
YOU WERE.

1295
00:56:01,906 --> 00:56:05,877
WHAT I WORRY ABOUT WITH THE FDA

1296
00:56:05,877 --> 00:56:10,181
IS THAT WAS SORT OF -- THAT WAS

1297
00:56:10,181 --> 00:56:11,382
AN AGENCY-WIDE DIRECTIVE FROM

1298
00:56:11,382 --> 00:56:13,217
CONGRESS THAT EVERY AGENCY

1299
00:56:13,217 --> 00:56:16,187
SHOULD BE THINKING ABOUT

1300
00:56:16,187 --> 00:56:16,688
LIFESPAN POLICIES.

1301
00:56:16,688 --> 00:56:22,360
AND FDA AS FAR AS I CAN TELL TO

1302
00:56:22,360 --> 00:56:24,062
DATE DOES NOT PAY MUCH ATTENTION

1303
00:56:24,062 --> 00:56:26,564
TO INCLUSION OF OLDER ADULTS

1304
00:56:26,564 --> 00:56:29,100
WHEN IT'S GOING THROUGH ITS

1305
00:56:29,100 --> 00:56:29,500
APPROVAL PROCESS.

1306
00:56:29,500 --> 00:56:32,036
SO I THINK THE HACKLES GOING UP,

1307
00:56:32,036 --> 00:56:35,239
I APPRECIATE THAT BECAUSE I

1308
00:56:35,239 --> 00:56:36,974
THINK THAT'S WHAT HAPPENS WITH

1309
00:56:36,974 --> 00:56:38,976
AGS AND OUR LEADERS IS THAT

1310
00:56:38,976 --> 00:56:40,611
DRUGS GET APPROVED AND THEN THEY

1311
00:56:40,611 --> 00:56:42,246
GET ROLLED OUT IN A POPULATION

1312
00:56:42,246 --> 00:56:44,849
THAT THEY HAVE NEVER BEEN TESTED

1313
00:56:44,849 --> 00:56:46,517
IN AND THAT POPULATION IS THE

1314
00:56:46,517 --> 00:56:48,486
BIGGEST USER OF THOSE DRUGS.

1315
00:56:48,486 --> 00:56:52,090
SO I THINK REALLY IF THERE'S

1316
00:56:52,090 --> 00:56:54,592
ANYTHING IN THE INTERAGENCY

1317
00:56:54,592 --> 00:56:56,461
DELIBERATIONS AND CONVERSATIONS

1318
00:56:56,461 --> 00:56:59,397
THAT YOU HAVE THAT COULD HELP TO

1319
00:56:59,397 --> 00:57:02,166
CONVEY TO FDA HOW IMPORTANT THAT

1320
00:57:02,166 --> 00:57:04,535
IS TO THE COMMUNITY, THAT WE

1321
00:57:04,535 --> 00:57:07,338
START TO SEE THAT INCLUSION IN

1322
00:57:07,338 --> 00:57:13,177
THESE APPROVALS THAT WOULD BE

1323
00:57:13,177 --> 00:57:14,512
GREAT FROM MY PERSPECTIVE.

1324
00:57:14,512 --> 00:57:16,147
I RECOGNIZE I'M THINKING ABOUT

1325
00:57:16,147 --> 00:57:19,016
THE TIME TOGETHER AS AGENCY HAS

1326
00:57:19,016 --> 00:57:20,118
WHERE THESE CONVERSATIONS MIGHT

1327
00:57:20,118 --> 00:57:26,924
BE HAD AND JUST AS SOMEBODY

1328
00:57:26,924 --> 00:57:29,427
QUIPPED ABOUT ME, I HAVE TALKING

1329
00:57:29,427 --> 00:57:30,828
POINTS, THIS IS ONE OF THEM, I

1330
00:57:30,828 --> 00:57:32,029
WILL SAY AT ANY TIME.

1331
00:57:32,029 --> 00:57:33,564
>> THANK YOU FOR THE
PROMPT.

1332
00:57:33,564 --> 00:57:35,600
WHEN THERE ARE OPPORTUNITIES OF

1333
00:57:35,600 --> 00:57:36,634
INTERACTION WE'LL PURSUE.

1334
00:57:36,634 --> 00:57:37,969
WE HAVE OUR RESPONSIBILITY IN

1335
00:57:37,969 --> 00:57:39,170
RESEARCH WE SUPPORT BUT THAT'S

1336
00:57:39,170 --> 00:57:40,805
NOT THE ONLY RESEARCH THAT

1337
00:57:40,805 --> 00:57:41,773
SUPPORTS FDA DECISIONS.

1338
00:57:41,773 --> 00:57:46,377
SO  THE INFLUENCE OF THEIR

1339
00:57:46,377 --> 00:57:51,182
POLICY ON NOT JUST FEDERALLY 

1340
00:57:51,182 --> 00:57:52,183
FUNDED RESEARCH BUT BROADER

1341
00:57:52,183 --> 00:57:53,918
RESEARCH WOULD HAVE UNIQUE

1342
00:57:53,918 --> 00:57:58,623
SIGNIFICANCE, AGREED. 

1343
00:57:58,623 --> 00:57:59,056
>> ALL RIGHT.

1344
00:57:59,056 --> 00:58:02,226
THANK YOU VERY MUCH FOR THE

1345
00:58:02,226 --> 00:58:02,860
DISCUSSION.

1346
00:58:02,860 --> 00:58:04,662
WE'LL MOVE ON.

1347
00:58:04,662 --> 00:58:13,638
NEXT UP IS JUST ANNOUNCEMENT OF

1348
00:58:13,638 --> 00:58:16,808
FUTURE MEETING DATES.

1349
00:58:16,808 --> 00:58:19,110
YOU'LL SEE AGAIN WE'LL BE

1350
00:58:19,110 --> 00:58:21,846
MEETING IN PERSON ON WEDNESDAY,

1351
00:58:21,846 --> 00:58:24,115
SEPTEMBER 18, AND THURSDAY,

1352
00:58:24,115 --> 00:58:24,448
SEPTEMBER 19.

1353
00:58:24,448 --> 00:58:30,721
THIS TIME IT WILL BE IN BUILDING

1354
00:58:30,721 --> 00:58:33,124
31, THE CONFERENCE ROOM, A

1355
00:58:33,124 --> 00:58:35,526
DIFFERENT VENUE THAN HERE AT

1356
00:58:35,526 --> 00:58:38,596
NATCHER, BETTER CAFETERIA, THANK

1357
00:58:38,596 --> 00:58:38,763
GOD.

1358
00:58:38,763 --> 00:58:42,333
AND WE'LL WORK SOMETHING OUT TOO

1359
00:58:42,333 --> 00:58:44,402
BECAUSE SEPTEMBER IS USUALLY OUR

1360
00:58:44,402 --> 00:58:46,804
BUSY COUNCIL MEETING WITH LOTS

1361
00:58:46,804 --> 00:58:49,106
OF NEW INITIATIVES THAT WILL BE

1362
00:58:49,106 --> 00:58:49,373
PRESENTED.

1363
00:58:49,373 --> 00:58:52,944
SO WE'LL WORK WITH YOU ON THAT.

1364
00:58:52,944 --> 00:58:55,713
AND THEN IN 2025, OF COURSE,

1365
00:58:55,713 --> 00:58:58,850
JANUARY 28 AND 29 IS OUR JANUARY

1366
00:58:58,850 --> 00:59:02,453
COUNCIL MEETING, WHICH IS

1367
00:59:02,453 --> 00:59:04,522
VIRTUAL AS ALWAYS.

1368
00:59:04,522 --> 00:59:07,024
WHICH THEN WE'LL BE MOVING TO

1369
00:59:07,024 --> 00:59:10,428
MAY 13 AND 14 OF 2025, AND

1370
00:59:10,428 --> 00:59:12,563
SEPTEMBER 17 AND 18.

1371
00:59:12,563 --> 00:59:16,133
SO PLEASE MARK YOUR CALENDARS

1372
00:59:16,133 --> 00:59:17,902
FOR THOSE.

1373
00:59:17,902 --> 00:59:19,871
WE HAVE NATCHER BOOKED FOR THOSE

1374
00:59:19,871 --> 00:59:24,475
MEETINGS RIGHT NOW BUT AS

1375
00:59:24,475 --> 00:59:26,644
RICHARD MENTIONED EARLIER OUR

1376
00:59:26,644 --> 00:59:27,545
EXTRAMURAL STAFF AND PROGRAMS

1377
00:59:27,545 --> 00:59:32,783
WILL BE ALL MOVING TO A NEW

1378
00:59:32,783 --> 00:59:35,753
BUILDING IN THE SUMMER TO

1379
00:59:35,753 --> 00:59:37,722
FISHERS LANES IN CONJUNCTION

1380
00:59:37,722 --> 00:59:40,558
WITH NIAID WHO IS HOUSED IN THE

1381
00:59:40,558 --> 00:59:41,025
SAME BUILDING.

1382
00:59:41,025 --> 00:59:45,062
IT'S A PRETTY BRAND NEW

1383
00:59:45,062 --> 00:59:46,998
BUILDING, HAS A COMPLETELY

1384
00:59:46,998 --> 00:59:48,232
RENOVATED AND NEW CONFERENCE

1385
00:59:48,232 --> 00:59:49,433
CENTER IN THOSE BUILDINGS SO

1386
00:59:49,433 --> 00:59:51,302
WE'RE HOPING TO BE ABLE TO USE

1387
00:59:51,302 --> 00:59:55,239
THAT BUILDING FOR OUR MEETINGS

1388
00:59:55,239 --> 00:59:56,107
IN THE FUTURE.

1389
00:59:56,107 --> 01:00:06,584
IT WILL BE A GREAT SPOT FOR

1390
01:00:08,986 --> 01:00:10,121
EVERYONE.

1391
01:00:10,121 --> 01:00:11,622
IN YOUR ELECTRONIC COUNCIL BOOK

1392
01:00:11,622 --> 01:00:14,258
MINUTES FROM MEETING OF JANUARY

1393
01:00:14,258 --> 01:00:14,492
2024

1394
01:00:14,492 --> 01:00:16,027
I'LL MAKE A MOTION TO APPROVE

1395
01:00:16,027 --> 01:00:18,429
THOSE MEETING MINUTES FROM THE

1396
01:00:18,429 --> 01:00:19,764
LAST TIME, UNLESS ANYONE HAS

1397
01:00:19,764 --> 01:00:25,870
CORRECTIONS OR COMMENTS ON THOSE

1398
01:00:25,870 --> 01:00:26,103
MINUTES.

1399
01:00:26,103 --> 01:00:27,838
MOVE TO APPROVE.

1400
01:00:27,838 --> 01:00:28,072
SECOND.

1401
01:00:28,072 --> 01:00:30,141
ALL IN FAVOR.

1402
01:00:30,141 --> 01:00:31,542
ANY OPPOSED.

1403
01:00:31,542 --> 01:00:34,745
WE HAVE APPROVAL OF OUR MINUTES

1404
01:00:34,745 --> 01:00:38,683
FROM THE JANUARY 2024 COUNCIL.

1405
01:00:38,683 --> 01:00:41,852
THANK YOU VERY MUCH.

1406
01:00:41,852 --> 01:00:51,829
NEXT WE ARE RESURRECTING

1407
01:00:51,829 --> 01:00:53,230
SOMETHING THAT WE HAVEN'T DONE

1408
01:00:53,230 --> 01:00:55,533
IN A LONG TIME, CERTIFICATES OF

1409
01:00:55,533 --> 01:00:57,601
APPRECIATION FOR RETIRING

1410
01:00:57,601 --> 01:01:03,407
MEMBERS OF COUNCIL, SO A SMALL

1411
01:01:03,407 --> 01:01:05,276
PRESENTATION FOR PEOPLE

1412
01:01:05,276 --> 01:01:05,843
RETIRING.

1413
01:01:05,843 --> 01:01:10,648
WE HAVE THREE GOING OFF COUNCIL

1414
01:01:10,648 --> 01:01:16,120
THIS ROUND, DOCTORS MANLEY AND

1415
01:01:16,120 --> 01:01:18,222
WEIR, CHARLOTTE, DR. PETERSON

1416
01:01:18,222 --> 01:01:21,058
WILL ALSO BE RETIRING THIS

1417
01:01:21,058 --> 01:01:21,258
ROUND.

1418
01:01:21,258 --> 01:01:31,769
RICHARD, IF YOU WANT TO HAVE 

1419
01:01:39,010 --> 01:01:39,910
THOSE.

1420
01:01:39,910 --> 01:01:41,245
OKAY.

1421
01:01:41,245 --> 01:01:43,114
>> OLD SCHOOL, REAL
CERTIFICATES

1422
01:01:43,114 --> 01:01:44,181
AND PRESENTED IN PERSON.

1423
01:01:44,181 --> 01:01:46,917
CAN YOU SAY A FEW WORDS IF YOU'D

1424
01:01:46,917 --> 01:01:47,118
LIKE.

1425
01:01:47,118 --> 01:01:51,956
WELL, COME OVER, HOW ABOUT IT?

1426
01:01:51,956 --> 01:01:54,892
JENNIFER MANLY SERVED ON COUNCIL

1427
01:01:54,892 --> 01:01:56,794
MOST ABLY, PREVIOUSLY BOARD OF

1428
01:01:56,794 --> 01:01:58,095
SCIENTIFIC COUNSELORS, ALMOST OF

1429
01:01:58,095 --> 01:02:03,334
COURSE WE DO WITH ENERGY, WITH

1430
01:02:03,334 --> 01:02:06,737
PERSPECTIVE THAT KEPT US ON OUR

1431
01:02:06,737 --> 01:02:08,806
TOES AROUND HER, IN THE MOST

1432
01:02:08,806 --> 01:02:09,707
POSITIVE WAY.

1433
01:02:09,707 --> 01:02:11,042
WE'LL MISS YOU AND MOST

1434
01:02:11,042 --> 01:02:18,149
CERTAINLY WILL NOT ALLOW YOU TO

1435
01:02:18,149 --> 01:02:22,853
ESCAPE, WE'LL INVOLVE YOU IN

1436
01:02:22,853 --> 01:02:23,754
FUTURE EFFORTS.

1437
01:02:23,754 --> 01:02:25,356
HERE IS A WONDERFUL REAL PRINTED

1438
01:02:25,356 --> 01:02:33,898
...

1439
01:02:33,898 --> 01:02:36,100
>> I'M GOING TO MISS ALL
OF YOU

1440
01:02:36,100 --> 01:02:37,068
TOO.

1441
01:02:37,068 --> 01:02:39,503
IT'S BEEN A PLEASURE AND I'VE

1442
01:02:39,503 --> 01:02:41,272
LEARNED SO MUCH.

1443
01:02:41,272 --> 01:02:43,674
I REALLY HAVE LOVED MY TIME ON

1444
01:02:43,674 --> 01:02:44,208
COUNCIL.

1445
01:02:44,208 --> 01:02:47,912
IT'S WONDERFUL WHEN YOU CAN SAY

1446
01:02:47,912 --> 01:02:50,114
THAT, YOU KNOW, SERVICE LIKE

1447
01:02:50,114 --> 01:02:54,618
THIS TO NIA HAS BROUGHT SO MUCH

1448
01:02:54,618 --> 01:02:59,290
MORE KNOWLEDGE AND NEW FRIENDS,

1449
01:02:59,290 --> 01:03:00,257
NEW RELATIONSHIPS WITH PEOPLE

1450
01:03:00,257 --> 01:03:05,329
WHOSE WORK I HAVE A WHOLE NEW

1451
01:03:05,329 --> 01:03:05,729
APPRECIATION FOR.

1452
01:03:05,729 --> 01:03:14,939
SO, THANK YOU SO MUCH.

1453
01:03:14,939 --> 01:03:20,644
 

1454
01:03:20,644 --> 01:03:24,482
>> NEXT DAVID WEIR.

1455
01:03:24,482 --> 01:03:27,318
DAVID HAS HAD ALSO, AS FOR EACH

1456
01:03:27,318 --> 01:03:29,120
OF YOU, ENORMOUSLY IMPACTFUL

1457
01:03:29,120 --> 01:03:33,591
CAREER, LEADERSHIP IN AREAS OF

1458
01:03:33,591 --> 01:03:37,828
POPULATION SCIENCE, COGNITION

1459
01:03:37,828 --> 01:03:41,565
AND OTHER AREAS, HRS, MODEL FOR

1460
01:03:41,565 --> 01:03:43,434
POPULATION-BASED RESEARCH,

1461
01:03:43,434 --> 01:03:45,836
SERVED US WELL, GENEROUS WITH

1462
01:03:45,836 --> 01:03:47,905
TIME, SO MANY NIH-SUPPORTED

1463
01:03:47,905 --> 01:03:48,606
FUNCTIONS INCLUDING COUNCIL.

1464
01:03:48,606 --> 01:03:49,974
WE'LL MISS YOU AND ASK YOU TO

1465
01:03:49,974 --> 01:03:55,012
SAY A FEW WORDS TO US.

1466
01:03:55,012 --> 01:03:56,347
>> THANK YOU, IT'S BEEN A

1467
01:03:56,347 --> 01:03:57,515
TREMENDOUS EXPERIENCE TO GET TO

1468
01:03:57,515 --> 01:04:02,019
KNOW PEOPLE ON COUNCIL BUT ALSO

1469
01:04:02,019 --> 01:04:03,454
PEOPLE AT NIA, GAINED A BETTER

1470
01:04:03,454 --> 01:04:06,290
APPRECIATION OF DEPTH AND

1471
01:04:06,290 --> 01:04:07,825
BREADTH OF WORK, DEEPER AND

1472
01:04:07,825 --> 01:04:10,895
BROADER EVERY DAY IT SEEMS.

1473
01:04:10,895 --> 01:04:18,335
PROJECT I WORK ON MAINLY IS

1474
01:04:18,335 --> 01:04:19,436
COOPERATIVE AGREEMENT.

1475
01:04:19,436 --> 01:04:22,306
IT'S BEEN A WONDERFUL LEARNING

1476
01:04:22,306 --> 01:04:23,507
EXPERIENCE AND I'M JUST GLAD TO

1477
01:04:23,507 --> 01:04:27,011
BE PART OF AN ORGANIZATION 

1478
01:04:27,011 --> 01:04:28,779
THAT'S SO FORWARD LOOKING AND

1479
01:04:28,779 --> 01:04:39,356
JUST A TERRIFIC SCIENTIFIC ENTI.

1480
01:04:42,393 --> 01:04:43,527
THANK YOU.

1481
01:04:43,527 --> 01:04:49,767
>> AND CHARLOTTE.

1482
01:04:49,767 --> 01:04:52,069
RESEARCH SPANNED BASIC MECHANISM

1483
01:04:52,069 --> 01:04:54,371
THROUGH FUNCTION, WORKING WITH

1484
01:04:54,371 --> 01:04:56,106
COMMON FUND AROUND MoTrPAC,

1485
01:04:56,106 --> 01:04:58,842
SPANS OUR DIVISION AND RESEARCH

1486
01:04:58,842 --> 01:05:00,077
DISCIPLINES, ALL OF THAT AND

1487
01:05:00,077 --> 01:05:01,545
MORE, WE THANK YOU AND ASK YOU

1488
01:05:01,545 --> 01:05:03,214
TO SAY A FEW WORDS TO US.

1489
01:05:03,214 --> 01:05:03,547
>> THANKS.

1490
01:05:03,547 --> 01:05:05,983
THIS HAS BEEN A PLEASURE.

1491
01:05:05,983 --> 01:05:08,052
I'M SORRY I'M LEAVING AFTER ONLY

1492
01:05:08,052 --> 01:05:14,892
THREE YEARS BUT IT HAS BEEN SO 

1493
01:05:14,892 --> 01:05:17,061
CLOSELY INVOLVED WITH BAB, ALSO

1494
01:05:17,061 --> 01:05:18,629
WITH CLINICAL GERONTOLOGY

1495
01:05:18,629 --> 01:05:19,463
PROGRAM OFFICERS, SO SUPPORTIVE

1496
01:05:19,463 --> 01:05:20,998
THROUGH THE YEARS BUT NOW THEY

1497
01:05:20,998 --> 01:05:23,200
GET TO SEE THE BIG PICTURE AND

1498
01:05:23,200 --> 01:05:26,036
HOW HARD EVERYBODY WORKS IN THE

1499
01:05:26,036 --> 01:05:30,407
WONDERFUL WORK THAT NIA DOES,

1500
01:05:30,407 --> 01:05:31,842
ENLIGHTENING, APPRECIATE HOW

1501
01:05:31,842 --> 01:05:34,245
HARD AND WHAT A WONDERFUL JOB

1502
01:05:34,245 --> 01:05:35,112
NIA IS DOING.

1503
01:05:35,112 --> 01:05:37,748
I HOPE I'LL BE ABLE TO COME BACK

1504
01:05:37,748 --> 01:05:38,749
IN THE FUTURE.

1505
01:05:38,749 --> 01:05:49,026
I DO THANK YOU. 

1506
01:05:57,534 --> 01:05:58,869
IT'S BEEN WONDERFUL.

1507
01:05:58,869 --> 01:05:59,770
>> THANKS TO EACH.

1508
01:05:59,770 --> 01:06:01,071
YOU'LL BE MISSED.

1509
01:06:01,071 --> 01:06:02,506
YOU SAID STANDARDS, HIGH BARS.

1510
01:06:02,506 --> 01:06:04,575
YOU CAN CONTINUE AND I HOPE WILL

1511
01:06:04,575 --> 01:06:08,712
BE AMBASSADORS AND  EDUCATORS TO

1512
01:06:08,712 --> 01:06:11,582
THE COMMUNITY, WHAT GOES ON AT

1513
01:06:11,582 --> 01:06:14,852
COUNCIL, IMPORTANT THAT YOU

1514
01:06:14,852 --> 01:06:16,487
SERVED, AND INSIGHTS YOU SHOULD

1515
01:06:16,487 --> 01:06:18,589
BE MORE THAN FREE TO SHARE.

1516
01:06:18,589 --> 01:06:19,657
WE'RE HERE TO WORK WITH AND

1517
01:06:19,657 --> 01:06:22,159
SERVE THE COMMUNITY.

1518
01:06:22,159 --> 01:06:24,361
THAT PLUS ANY OF THE WORKS YOU

1519
01:06:24,361 --> 01:06:26,230
MAY FIND ON THE SYSTEM, PLEASE

1520
01:06:26,230 --> 01:06:29,266
DO SHARE WITH US AND THE

1521
01:06:29,266 --> 01:06:30,167
RESEARCH COMMUNITY AS WELL.

1522
01:06:30,167 --> 01:06:31,235
YOU'LL BE MISSED.

1523
01:06:31,235 --> 01:06:33,137
WE'VE GOT YOU FOR A FEW MORE

1524
01:06:33,137 --> 01:06:35,973
HOURS.

1525
01:06:35,973 --> 01:06:36,740
>> ALL RIGHT.

1526
01:06:36,740 --> 01:06:39,076
I ALSO WANT TO EXTEND MY

1527
01:06:39,076 --> 01:06:41,345
GRATITUDE AND THANKS TO THE

1528
01:06:41,345 --> 01:06:43,113
RETIRING MEMBERS.

1529
01:06:43,113 --> 01:06:45,282
YOU'LL BE SORELY MISSED.

1530
01:06:45,282 --> 01:06:47,351
WE GREATLY APPRECIATE YOUR

1531
01:06:47,351 --> 01:06:51,188
EXPERTISE AND HONESTY THAT YOU

1532
01:06:51,188 --> 01:06:53,824
BRING TO THE COUNCIL AND

1533
01:06:53,824 --> 01:06:55,025
ADVISORY, TO OUR INSTITUTE, IT'S

1534
01:06:55,025 --> 01:07:00,497
BEEN A PLEASURE WORKING WITH YOU

1535
01:07:00,497 --> 01:07:03,000
ALL.

1536
01:07:03,000 --> 01:07:09,807
OKAY. 

1537
01:07:09,807 --> 01:07:11,875
SO NEXT UP, OKAY.

1538
01:07:11,875 --> 01:07:14,178
WE'LL JUST -- WELL, THE FIRST

1539
01:07:14,178 --> 01:07:17,448
UP, WE'LL BE DOING OUR REPORT ON

1540
01:07:17,448 --> 01:07:19,049
THE TASK FORCE FOR MINORITY

1541
01:07:19,049 --> 01:07:19,650
AGING.

1542
01:07:19,650 --> 01:07:28,525
I'LL TURN IT OVER TO PATRICIA

1543
01:07:28,525 --> 01:07:29,626
AND THE CHAIRS.

1544
01:07:29,626 --> 01:07:31,995
>> THANK YOU AND GOOD
MORNING.

1545
01:07:31,995 --> 01:07:35,065
I'LL QUICKLY PIVOT TO OUR

1546
01:07:35,065 --> 01:07:36,700
CO-CHAIRS, YESTERDAY'S

1547
01:07:36,700 --> 01:07:37,267
CONVERSATION WAS THOUGHT

1548
01:07:37,267 --> 01:07:38,902
PROVOKING AND THEY WILL DO A

1549
01:07:38,902 --> 01:07:40,304
FANTASTIC JOB SUMMARIZING KEY

1550
01:07:40,304 --> 01:07:41,405
POINTS AND TAKEAWAYS.

1551
01:07:41,405 --> 01:07:43,607
I WANT TO ACKNOWLEDGE KEN FOR

1552
01:07:43,607 --> 01:07:45,876
GIVING ADDITIONAL FEW MINUTES TO

1553
01:07:45,876 --> 01:07:46,877
ENGAGE IN FURTHER CONVERSATION.

1554
01:07:46,877 --> 01:07:50,047
THAT'S A GIFT AND WE APPRECIATE

1555
01:07:50,047 --> 01:07:50,214
IT.

1556
01:07:50,214 --> 01:07:52,683
THANK YOU.

1557
01:07:52,683 --> 01:07:55,419
>> THANK YOU, DR. JONES.

1558
01:07:55,419 --> 01:07:58,088
THANK YOU, KEN. 

1559
01:07:58,088 --> 01:07:59,123
DO YOU HEAR ME?

1560
01:07:59,123 --> 01:07:59,323
OKAY.

1561
01:07:59,323 --> 01:08:00,057
ALL RIGHT.

1562
01:08:00,057 --> 01:08:02,860
THANK YOU FOR THE EXTRA MINUTES

1563
01:08:02,860 --> 01:08:03,127
YESTERDAY.

1564
01:08:03,127 --> 01:08:07,030
IT WAS INDEED A TERRIFIC

1565
01:08:07,030 --> 01:08:07,264
SESSION.

1566
01:08:07,264 --> 01:08:10,634
I WAS INSPIRED, LEFT THINKING

1567
01:08:10,634 --> 01:08:14,638
ABOUT WHAT WE HEARD DURING

1568
01:08:14,638 --> 01:08:15,572
YESTERDAY'S SESSION.

1569
01:08:15,572 --> 01:08:21,111
AND AS YOU WILL RECALL WE

1570
01:08:21,111 --> 01:08:23,447
STARTED WITH DR. JONES OPENING

1571
01:08:23,447 --> 01:08:26,517
REMARKS, MADE ANNOUNCEMENTS

1572
01:08:26,517 --> 01:08:29,119
WORTH REPEATING.

1573
01:08:29,119 --> 01:08:30,587
THERE'S THE 2024 BUTLER-WILLIAMS

1574
01:08:30,587 --> 01:08:33,090
SCHOLAR PROGRAM, WILL BE

1575
01:08:33,090 --> 01:08:36,260
CONVENING IN AUGUST, COMING UP.

1576
01:08:36,260 --> 01:08:39,329
SHE ALSO REMINDED US ABOUT THE

1577
01:08:39,329 --> 01:08:41,932
STRUCTURAL RACISM WORKSHOP

1578
01:08:41,932 --> 01:08:45,803
THAT'S HAPPENING IN JULY, AND

1579
01:08:45,803 --> 01:08:49,273
REGISTRATION IS COMING UP.

1580
01:08:49,273 --> 01:08:53,644
SHE ALSO REMINDED US ABOUT THE

1581
01:08:53,644 --> 01:08:57,281
DOMAIN OF THE TASK FORCE.

1582
01:08:57,281 --> 01:09:02,085
AND THAT WE HAD DRIVEN BY THREE

1583
01:09:02,085 --> 01:09:03,821
DOMAINS, SCIENCE OF INCLUSION

1584
01:09:03,821 --> 01:09:06,457
FIRST, THE SCIENCE OF

1585
01:09:06,457 --> 01:09:10,093
ELIMINATING HEALTH DISPARITIES 

1586
01:09:10,093 --> 01:09:10,627
SECOND.

1587
01:09:10,627 --> 01:09:12,896
AND THIRDLY, METHODS USED TO

1588
01:09:12,896 --> 01:09:14,898
EXAMINE THE HEALTH OF

1589
01:09:14,898 --> 01:09:15,766
MINORITIZED POPULATIONS.

1590
01:09:15,766 --> 01:09:20,637
I THOUGHT THAT WAS AN IMPORTANT

1591
01:09:20,637 --> 01:09:23,740
REMINDER THAT WAS GIVEN TO US BY

1592
01:09:23,740 --> 01:09:26,810
DR. JONES. 

1593
01:09:26,810 --> 01:09:31,615
WE HEARD FROM DR. TURNER, DR.

1594
01:09:31,615 --> 01:09:34,585
ROBERT TURNER, AND HE IS

1595
01:09:34,585 --> 01:09:36,420
CONDUCTING ADRD AND AGING

1596
01:09:36,420 --> 01:09:38,722
RESEARCH WITH BLACK MEN FROM A

1597
01:09:38,722 --> 01:09:41,258
LIFE COURSE PERSPECTIVE.

1598
01:09:41,258 --> 01:09:42,793
HE'S AN ASSISTANT PROFESSOR

1599
01:09:42,793 --> 01:09:44,828
WITHIN THE DEPARTMENT OF

1600
01:09:44,828 --> 01:09:48,932
NEUROLOGY AT GEORGE WASHINGTON 

1601
01:09:48,932 --> 01:09:50,701
UNIVERSITY, MY ALMA MATER.

1602
01:09:50,701 --> 01:09:55,272
HE TALKED TO US ABOUT HOW SPORT

1603
01:09:55,272 --> 01:09:57,474
PARTICIPATION INFLUENCED BRAIN

1604
01:09:57,474 --> 01:09:58,108
HEALTH.

1605
01:09:58,108 --> 01:09:59,209
HE DESCRIBED SELF-IDENTIFIED

1606
01:09:59,209 --> 01:10:01,078
BLACK MEN'S EXPERIENCE WITH

1607
01:10:01,078 --> 01:10:02,946
BRAIN HEALTH IN AGING RESEARCH.

1608
01:10:02,946 --> 01:10:06,984
HE TALKED TO US ABOUT STRATEGIES

1609
01:10:06,984 --> 01:10:07,985
TO FACILITATE SELF-IDENTIFIED

1610
01:10:07,985 --> 01:10:11,355
BLACK MEN PARTICIPATION IN BRAIN

1611
01:10:11,355 --> 01:10:12,456
HEALTH AND AGING.

1612
01:10:12,456 --> 01:10:15,959
HE ALSO TALKED ABOUT RECRUITMENT

1613
01:10:15,959 --> 01:10:18,662
AND ENGAGEMENT ELEMENTS THAT

1614
01:10:18,662 --> 01:10:19,530
FACILITATE RETENTION OF

1615
01:10:19,530 --> 01:10:20,731
SELF-IDENTIFIED BLACK MEN AND

1616
01:10:20,731 --> 01:10:24,735
SPECIFICALLY IN BRAIN HEALTH AND

1617
01:10:24,735 --> 01:10:27,037
AGING RESEARCH.

1618
01:10:27,037 --> 01:10:29,439
HE TALKED TO US ABOUT THE BLACK

1619
01:10:29,439 --> 01:10:32,276
MEN'S EXPERIENCE IN AGING

1620
01:10:32,276 --> 01:10:33,043
RESEARCH.

1621
01:10:33,043 --> 01:10:35,879
HE SHARED BLACK MEN ARE

1622
01:10:35,879 --> 01:10:36,513
UNDERREPRESENTED IN ADRD

1623
01:10:36,513 --> 01:10:38,282
RESEARCH, BUT THAT THEY ARE

1624
01:10:38,282 --> 01:10:39,616
WILLING TO PARTICIPATE IN

1625
01:10:39,616 --> 01:10:40,384
RESEARCH.

1626
01:10:40,384 --> 01:10:42,553
AND THAT THE FACTORS INFLUENCING

1627
01:10:42,553 --> 01:10:44,388
THEIR LACK OF PARTICIPATION IS

1628
01:10:44,388 --> 01:10:47,157
PARTIALLY DUE TO THE FACT THAT

1629
01:10:47,157 --> 01:10:49,359
BLACK MALE PLAYERS IN THIS CASE

1630
01:10:49,359 --> 01:10:51,662
SAID THEY HAVE NEVER BEEN ASKED,

1631
01:10:51,662 --> 01:10:54,164
THEY THINK NOBODY CARES ABOUT

1632
01:10:54,164 --> 01:10:55,032
THEM.

1633
01:10:55,032 --> 01:10:56,800
HE REMINDED US THAT IT IS

1634
01:10:56,800 --> 01:10:58,869
CRITICALLY IMPORTANT TO CREATE

1635
01:10:58,869 --> 01:11:01,605
AN ENVIRONMENT WHERE THEY FEEL

1636
01:11:01,605 --> 01:11:03,373
THEY ARE BEING LISTENED TO.

1637
01:11:03,373 --> 01:11:05,576
BLACK MEN FEEL MORE COMFORTABLE

1638
01:11:05,576 --> 01:11:06,810
PARTICIPATING IN RESEARCH WITH

1639
01:11:06,810 --> 01:11:09,112
INVESTIGATORS WHO LOOK LIKE

1640
01:11:09,112 --> 01:11:09,513
THEM.

1641
01:11:09,513 --> 01:11:12,249
TO HELP THEM IMPROVE PARTICIPANT

1642
01:11:12,249 --> 01:11:13,183
INVOLVEMENT AMONG AFRICAN

1643
01:11:13,183 --> 01:11:15,352
AMERICANS, AND BLACK MEN IN

1644
01:11:15,352 --> 01:11:18,188
PARTICULAR, IT IS IMPORTANT TO

1645
01:11:18,188 --> 01:11:23,894
EXPRESS A GENUINE INTEREST AND 

1646
01:11:23,894 --> 01:11:25,228
RESPECT FOR THE POPULATION.

1647
01:11:25,228 --> 01:11:26,863
WHEN ASKED WHAT CAN INSTITUTIONS

1648
01:11:26,863 --> 01:11:30,801
DO TO ENGAGE MORE BLACK MEN IN

1649
01:11:30,801 --> 01:11:32,803
RESEARCH, DR. TURNER RESPONDED

1650
01:11:32,803 --> 01:11:35,205
AND HIGHLIGHTED THE IMPORTANCE

1651
01:11:35,205 --> 01:11:37,608
OF HAVING COMMUNITY PERSPECTIVE

1652
01:11:37,608 --> 01:11:39,476
INFORM THE SCIENCE.

1653
01:11:39,476 --> 01:11:40,911
I THOUGHT THAT WAS VERY

1654
01:11:40,911 --> 01:11:41,878
INTERESTING AND IMPORTANT.

1655
01:11:41,878 --> 01:11:46,383
HE URGED US TO GO INTO THE

1656
01:11:46,383 --> 01:11:47,751
COMMUNITY WHERE BLACK MEN ARE

1657
01:11:47,751 --> 01:11:49,653
AND ASK MEMBERS OF THE COMMUNITY

1658
01:11:49,653 --> 01:11:51,188
TO GET INVOLVED.

1659
01:11:51,188 --> 01:11:53,890
GET TO KNOW THEIR CULTURE, TO

1660
01:11:53,890 --> 01:11:56,860
UNDERSTAND WHAT IS IMPORTANT TO

1661
01:11:56,860 --> 01:11:59,596
THEM. 

1662
01:11:59,596 --> 01:12:01,898
IT'S IMPORTANT TO LET BLACK

1663
01:12:01,898 --> 01:12:03,767
PARTICIPANTS SEE THEY ARE MAKING

1664
01:12:03,767 --> 01:12:07,270
THEIR COMMUNITIES BETTER AND

1665
01:12:07,270 --> 01:12:07,704
STRONGER.

1666
01:12:07,704 --> 01:12:14,478
THOSE ARE SOME HIGHLIGHTS OF HIS

1667
01:12:14,478 --> 01:12:17,547
PRESENTATION. 

1668
01:12:17,547 --> 01:12:19,249
WE THEN MOVED TO -- I CAN

1669
01:12:19,249 --> 01:12:23,787
CONTINUE OR DO YOU WANT TO GO?

1670
01:12:23,787 --> 01:12:26,456
>> I CAN TALK ABOUT JAIME,
WHO

1671
01:12:26,456 --> 01:12:28,425
DISCOVERED THE THE COMMUNITY

1672
01:12:28,425 --> 01:12:30,927
ENGAGED RESEARCH EXPERIENCES

1673
01:12:30,927 --> 01:12:35,432
WITH LATINOS IN ADRD RESEARCH.

1674
01:12:35,432 --> 01:12:37,167
HE'S ASSISTANT PROFESSOR AT

1675
01:12:37,167 --> 01:12:38,702
KANSAS, A DIRECTOR OF LATINO

1676
01:12:38,702 --> 01:12:42,105
HEALTH, BRAIN HEALTH LAB,

1677
01:12:42,105 --> 01:12:44,074
CO-DIRECTOR FOR BRAIN HEALTH,

1678
01:12:44,074 --> 01:12:50,313
ASSISTANT DIRECTOR OF INCLUSIVE

1679
01:12:50,313 --> 01:12:51,515
AT KU RESEARCH CENTER.

1680
01:12:51,515 --> 01:12:54,017
DISCUSSED THREE THINGS FOR HIS

1681
01:12:54,017 --> 01:12:55,218
PRESENTATION, DISCUSSED

1682
01:12:55,218 --> 01:12:59,389
DISPARITIES IN ADRD AMONG

1683
01:12:59,389 --> 01:13:02,993
LATINOS, HE DISCUSSED MODELS

1684
01:13:02,993 --> 01:13:03,927
EMPLOYING COMMUNITY ENGAGEMENT

1685
01:13:03,927 --> 01:13:04,861
AND LESSONS LEARN.

1686
01:13:04,861 --> 01:13:08,031
FOR THE MODELS HE LOOKED AT HIS

1687
01:13:08,031 --> 01:13:09,800
ENGAGEMENT MODELS WHICH CENTER

1688
01:13:09,800 --> 01:13:12,536
AROUND PARTICIPANT AND

1689
01:13:12,536 --> 01:13:16,273
RELATIONSHIP CENTERED RESEARCH,

1690
01:13:16,273 --> 01:13:17,374
CULTURAL ACCOMMODATION MODEL,

1691
01:13:17,374 --> 01:13:22,279
AND TEXT USER DESIGNED MODEL.

1692
01:13:22,279 --> 01:13:26,216
WITH DISPARITIES, HE TALKED

1693
01:13:26,216 --> 01:13:27,551
ABOUT FOUR DIFFERENT THINGS,

1694
01:13:27,551 --> 01:13:29,953
KNOWLEDGE, RISK, DETECTION AND

1695
01:13:29,953 --> 01:13:31,588
CARE, RESEARCH PARTICIPATION,

1696
01:13:31,588 --> 01:13:34,191
EACH BEING IMPORTANT IN ADRD AND

1697
01:13:34,191 --> 01:13:34,658
LATINOS.

1698
01:13:34,658 --> 01:13:37,527
EACH OF THOSE HE DISCUSSED A

1699
01:13:37,527 --> 01:13:39,696
LITTLE BIT FIRST ABOUT LOW

1700
01:13:39,696 --> 01:13:41,231
LEVELS OF KNOWLEDGE FOR INSTANCE

1701
01:13:41,231 --> 01:13:43,300
MANY THINK THAT MEMORY LOSS IS

1702
01:13:43,300 --> 01:13:45,502
NORMAL IN AGING, BOTH IN WHITES

1703
01:13:45,502 --> 01:13:48,038
AND LATINOS, BUT MORE SO IN

1704
01:13:48,038 --> 01:13:48,905
LATINOS, SIGNIFICANTLY MORE.

1705
01:13:48,905 --> 01:13:51,708
AND THEN HE SHOWED THERE WAS LOW

1706
01:13:51,708 --> 01:13:53,577
RESEARCH PARTICIPATION IN DRUG

1707
01:13:53,577 --> 01:13:55,345
TRIALS IN LATINOS COMPARED TO

1708
01:13:55,345 --> 01:13:55,979
WHITES.

1709
01:13:55,979 --> 01:13:58,849
HE ALSO SHOWED THAT LATINO ADRD

1710
01:13:58,849 --> 01:14:00,784
CAREGIVERS HAVE LOW ACCESS TO

1711
01:14:00,784 --> 01:14:05,188
SUPPORT AND MORE DEPRESSION THAN

1712
01:14:05,188 --> 01:14:08,258
WHITES. 

1713
01:14:08,258 --> 01:14:11,528
AND HE SHOWED LATINOS HAVE

1714
01:14:11,528 --> 01:14:13,196
HIGHER UNINSURED LESSER ACCESS

1715
01:14:13,196 --> 01:14:14,831
AND ATTAINMENT OF EDUCATION,

1716
01:14:14,831 --> 01:14:16,566
LOWER HOUSEHOLD INCOME AND

1717
01:14:16,566 --> 01:14:18,001
HIGHER POVERTY RATES.

1718
01:14:18,001 --> 01:14:19,770
HE SHOWED THEIR FEAR OF

1719
01:14:19,770 --> 01:14:21,171
DEPORTATION BEING QUITE HIGH.

1720
01:14:21,171 --> 01:14:24,007
HE SHOWED HIGH LEVELS OF

1721
01:14:24,007 --> 01:14:24,674
INTERPERSONAL DISCRIMINATION,

1722
01:14:24,674 --> 01:14:26,843
AND A LARGE LANGUAGE BARRIER,

1723
01:14:26,843 --> 01:14:29,379
ALL REALLY CONTRIBUTING TO THIS

1724
01:14:29,379 --> 01:14:32,449
DISPARITY IN RESEARCH AND IN

1725
01:14:32,449 --> 01:14:32,682
HEALTH.

1726
01:14:32,682 --> 01:14:35,819
HE SHARED SOME CULTURAL ELEMENTS

1727
01:14:35,819 --> 01:14:39,656
ALSO SUCH AS THE NEED OF THE

1728
01:14:39,656 --> 01:14:40,891
WARM INTERACTION AND DEMENTIA

1729
01:14:40,891 --> 01:14:43,927
MAYBE BEING CONSIDERED A

1730
01:14:43,927 --> 01:14:45,495
WEAKNESS IN MALES.

1731
01:14:45,495 --> 01:14:47,964
HE SHOWED COMMUNITY ENGAGED

1732
01:14:47,964 --> 01:14:49,733
RESEARCH FRAMEWORKS USING HIS

1733
01:14:49,733 --> 01:14:53,003
RESEARCH INCLUDING THE

1734
01:14:53,003 --> 01:14:55,338
PARTICIPANT RELATIONSHIP

1735
01:14:55,338 --> 01:14:56,439
RESEARCH, STRESSED BIDIRECTIONAL

1736
01:14:56,439 --> 01:14:57,674
RESEARCH AND CULTURAL

1737
01:14:57,674 --> 01:15:00,677
ACCOMMODATION MODEL, EXAMPLE

1738
01:15:00,677 --> 01:15:02,612
WOULD BE NOT REQUIRING SOCIAL

1739
01:15:02,612 --> 01:15:03,446
SECURITY NUMBER FOR INSTANCE

1740
01:15:03,446 --> 01:15:08,018
BECAUSE OF FEAR OF DEPORTATION.

1741
01:15:08,018 --> 01:15:10,287
STRESSED USER DESIGNED --

1742
01:15:10,287 --> 01:15:11,087
USER-CENTERED DESIGN,

1743
01:15:11,087 --> 01:15:12,422
INTERACTION IN USER FRIENDLY

1744
01:15:12,422 --> 01:15:15,358
ACCESSIBLE WAY GOING TO THEIR

1745
01:15:15,358 --> 01:15:19,062
SPACES, TAILORING OUR LANGUAGE

1746
01:15:19,062 --> 01:15:20,630
TO THEIR CULTURE.

1747
01:15:20,630 --> 01:15:25,869
FINALLY HE SHOWED US HIS WORK ON

1748
01:15:25,869 --> 01:15:27,838
THE TEST MESSAGING INTERVENTION,

1749
01:15:27,838 --> 01:15:32,342
AND HE USES THIS TEXT METHOD,

1750
01:15:32,342 --> 01:15:34,845
HAS AN R21 TO LOOK AT THE

1751
01:15:34,845 --> 01:15:37,013
DEVELOPMENT OF THIS TEXT

1752
01:15:37,013 --> 01:15:39,883
MESSAGING TO SUPPORT LATINO

1753
01:15:39,883 --> 01:15:43,053
DEMENTIA FAMILY CAREGIVERS.

1754
01:15:43,053 --> 01:15:44,120
HE'S NOTED LIMITATIONS

1755
01:15:44,120 --> 01:15:47,757
ASSOCIATED WITH USING THIS TEXT,

1756
01:15:47,757 --> 01:15:48,625
SHOWED GREAT PARTICIPATION IN

1757
01:15:48,625 --> 01:15:51,027
GREAT RESPONSE TO TEXTS HE WAS

1758
01:15:51,027 --> 01:15:55,498
SENDING, AND THE PEOPLE IN THIS,

1759
01:15:55,498 --> 01:15:57,467
PART OF HIS STUDY, ENJOYED

1760
01:15:57,467 --> 01:15:59,002
GETTING THESE TESTS AND FELT

1761
01:15:59,002 --> 01:16:00,871
MUCH BETTER IN MULTIPLE RESPECTS

1762
01:16:00,871 --> 01:16:05,141
BUT ALSO DID NOTE LIMITATIONS,

1763
01:16:05,141 --> 01:16:06,243
TURNOVER COMMUNITY LEADERS

1764
01:16:06,243 --> 01:16:09,946
AFFECTED SUSTAINABILITY OF THE

1765
01:16:09,946 --> 01:16:11,915
PROJECT, LACK OF BANDWIDTH

1766
01:16:11,915 --> 01:16:13,984
RESOURCES, LACK OF

1767
01:16:13,984 --> 01:16:14,885
SUSTAINABILITY OF FUNDING,

1768
01:16:14,885 --> 01:16:15,986
BECAUSE IT RELIES ON RESEARCH

1769
01:16:15,986 --> 01:16:18,288
GRANTS WHICH IS A CONTINUED

1770
01:16:18,288 --> 01:16:20,357
DIFFICULTY WHEN WE GO OUT TO

1771
01:16:20,357 --> 01:16:21,992
COMMUNITIES THAT ARE SPONSORED

1772
01:16:21,992 --> 01:16:24,928
BY GRANTS IF WE END SOMETHING.

1773
01:16:24,928 --> 01:16:27,130
HE TALKED ABOUT THAT.

1774
01:16:27,130 --> 01:16:29,332
LIMITED TIME BECAUSE OF

1775
01:16:29,332 --> 01:16:30,066
SCHEDULES, LIMITED DIVERSITY,

1776
01:16:30,066 --> 01:16:31,067
VOICES IN THE WORKING GROUP, A

1777
01:16:31,067 --> 01:16:32,836
LOT OF PEOPLE ARE AFRAID TO

1778
01:16:32,836 --> 01:16:33,570
SPEAK UP.

1779
01:16:33,570 --> 01:16:36,539
AND THEN HE DISCUSSED WHAT HE

1780
01:16:36,539 --> 01:16:37,774
WOULD DO DIFFERENTLY.

1781
01:16:37,774 --> 01:16:41,478
AND A COUPLE THINGS ALSO GO

1782
01:16:41,478 --> 01:16:45,315
ACROSS DIFFERENT RACIAL/ETHNIC

1783
01:16:45,315 --> 01:16:46,082
MINORITIES, CO-CREATING RESEARCH

1784
01:16:46,082 --> 01:16:47,083
QUESTIONS ASKING THE COMMUNITY

1785
01:16:47,083 --> 01:16:51,755
WHAT THEY WANT TO LEARN.

1786
01:16:51,755 --> 01:16:52,322
INTEGRATING ENGAGEMENT

1787
01:16:52,322 --> 01:16:53,723
ACTIVITIES WITHIN GRANT AFTER

1788
01:16:53,723 --> 01:16:54,925
INTERVENTION ENDS WHICH I

1789
01:16:54,925 --> 01:16:56,793
ALREADY DISCUSSED IS REALLY

1790
01:16:56,793 --> 01:16:57,761
IMPORTANT.

1791
01:16:57,761 --> 01:16:59,729
AND ENGAGING MORE OF THE

1792
01:16:59,729 --> 01:17:01,064
COMMUNITY ADVISORY BOARDS ON HOW

1793
01:17:01,064 --> 01:17:05,669
DO WE RETAIN AND HOW DO WE

1794
01:17:05,669 --> 01:17:06,303
DISSEMINATE FINDINGS, INTERPRET

1795
01:17:06,303 --> 01:17:08,805
FINDINGS, AND EXPLORING WAYS TO

1796
01:17:08,805 --> 01:17:11,541
CREATE SUSTAINABILITY IN

1797
01:17:11,541 --> 01:17:12,208
COMMUNITY PARTNERSHIPS BEYOND

1798
01:17:12,208 --> 01:17:16,146
THE GRANTS THAT WE HAVE.

1799
01:17:16,146 --> 01:17:19,716
AFTERWARDS WE DID DISCUSS AT BIT

1800
01:17:19,716 --> 01:17:22,285
GOING ON, DR. TURNER'S WORK,

1801
01:17:22,285 --> 01:17:23,586
ABOUT THE MALE PARTICIPATION

1802
01:17:23,586 --> 01:17:25,789
BECAUSE THERE'S VERY FEW MALE

1803
01:17:25,789 --> 01:17:27,090
CAREGIVERS IN THE LATINO WORLD

1804
01:17:27,090 --> 01:17:31,161
AND IT'S ALSO HARDER TO ENGAGE

1805
01:17:31,161 --> 01:17:32,462
IN RESEARCH.

1806
01:17:32,462 --> 01:17:33,229
>> WONDERFUL.

1807
01:17:33,229 --> 01:17:36,066
THANK YOU.

1808
01:17:36,066 --> 01:17:43,406
AND THEN WE HAD DR. BONNIE DURAN

1809
01:17:43,406 --> 01:17:46,476
PRESENT, TALKING ABOUT

1810
01:17:46,476 --> 01:17:47,243
COMMUNITY-BASED PARTICIPATORY

1811
01:17:47,243 --> 01:17:49,879
RESEARCH, AND SHE IS PROFESSOR

1812
01:17:49,879 --> 01:17:50,547
EMERITUS, UNIVERSITY OF

1813
01:17:50,547 --> 01:17:55,652
WASHINGTON SCHOOL OF SOCIAL WORK

1814
01:17:55,652 --> 01:17:56,920
AND PUBLIC HEALTH.

1815
01:17:56,920 --> 01:18:01,257
SHE GAVE US LOTS OF INFORMATION

1816
01:18:01,257 --> 01:18:05,128
BUT I WILL SUMMARIZE A COUPLE

1817
01:18:05,128 --> 01:18:08,198
POINTS, SHE HAS BOOKS, SHE HAS

1818
01:18:08,198 --> 01:18:10,266
WRITTEN AND INFORMED MANY OF US,

1819
01:18:10,266 --> 01:18:14,304
AS WE WENT THROUGH PUBLIC

1820
01:18:14,304 --> 01:18:14,738
HEALTH.

1821
01:18:14,738 --> 01:18:19,109
A COUPLE OF HER HIGHLIGHTS, SHE

1822
01:18:19,109 --> 01:18:20,877
DEFINED AND DESCRIBED

1823
01:18:20,877 --> 01:18:24,714
COMMUNITY-BASED PARTICIPATORY

1824
01:18:24,714 --> 01:18:27,650
RESEARCH WHICH SHE REFERS AS A

1825
01:18:27,650 --> 01:18:30,487
PARTNERSHIP APPROACH TO RESEARCH

1826
01:18:30,487 --> 01:18:33,223
THAT EQUITABLY INVOLVED

1827
01:18:33,223 --> 01:18:34,324
COMMUNITY MEMBERS, ORGANIZATIONS

1828
01:18:34,324 --> 01:18:35,325
REPRESENTATIVE AND RESEARCHERS

1829
01:18:35,325 --> 01:18:43,400
IN ALL ASPECTS OF THE RESEARCH

1830
01:18:43,400 --> 01:18:43,633
PROCESS.

1831
01:18:43,633 --> 01:18:45,301
DR. DURAN INDICATED COMMUNITY

1832
01:18:45,301 --> 01:18:46,336
BRACED PARTICIPATORY RESEARCH IS

1833
01:18:46,336 --> 01:18:49,305
THE WAY TO GO FOR COMMUNITY OF

1834
01:18:49,305 --> 01:18:50,407
COLOR AND HISTORICALLY

1835
01:18:50,407 --> 01:18:52,042
MARGINALIZED COMMUNITIES.

1836
01:18:52,042 --> 01:18:55,745
SHE EMPHASIZED THE IMPORTANCE OF

1837
01:18:55,745 --> 01:18:57,514
INTERVENTION RESEARCH, THIS

1838
01:18:57,514 --> 01:19:00,250
INVOLVES PROCESSES THAT HONOR

1839
01:19:00,250 --> 01:19:02,852
CULTURAL KNOWLEDGE AND COMMUNITY

1840
01:19:02,852 --> 01:19:04,954
VOICE, THAT LOCAL SETTINGS, AND

1841
01:19:04,954 --> 01:19:09,959
USED BOTH ACADEMIC AND COMMUNITY

1842
01:19:09,959 --> 01:19:12,395
LANGUAGE LEADING TO

1843
01:19:12,395 --> 01:19:13,797
STRENGTH-BASED CULTURE-CENTERED

1844
01:19:13,797 --> 01:19:14,264
INTERVENTIONS.

1845
01:19:14,264 --> 01:19:16,533
SHE EMPHASIZED THAT SEVERAL

1846
01:19:16,533 --> 01:19:17,867
TIMES DURING HER PRESENTATION.

1847
01:19:17,867 --> 01:19:24,307
SHE ALSO TALKED ABOUT THE 

1848
01:19:24,307 --> 01:19:25,642
IMPORTANCE OF SHARING RESOURCES

1849
01:19:25,642 --> 01:19:27,811
AND PAYING PEOPLE FOR

1850
01:19:27,811 --> 01:19:30,213
PARTICIPATING IN RESEARCH.

1851
01:19:30,213 --> 01:19:32,949
AS I SAID, I WAS -- ALL OF US

1852
01:19:32,949 --> 01:19:34,918
WERE INSPIRED BY HER

1853
01:19:34,918 --> 01:19:35,685
PRESENTATION AND HER COMMITMENT

1854
01:19:35,685 --> 01:19:41,257
TO THE FIELD. 

1855
01:19:41,257 --> 01:19:44,761
SO THAT'S A SUMMARY OF WHAT WE

1856
01:19:44,761 --> 01:19:47,931
TALKED ABOUT, WE HEARD

1857
01:19:47,931 --> 01:19:49,199
YESTERDAY.

1858
01:19:49,199 --> 01:19:52,435
I THINK A COUPLE OF DR. MANLY

1859
01:19:52,435 --> 01:19:56,172
MENTIONED THE ISSUE OF HEALTH

1860
01:19:56,172 --> 01:19:57,907
EQUITY TOURISM, AND THIS WAS --

1861
01:19:57,907 --> 01:20:05,915
THIS CAME UP IN DR. DURAN'S

1862
01:20:05,915 --> 01:20:06,983
PRESENTATION, IF DR. MANLY

1863
01:20:06,983 --> 01:20:11,821
WANTED TO EMPHASIZE ON THAT.

1864
01:20:11,821 --> 01:20:14,424
>> WELL, I THINK IF ANYONE
HERE

1865
01:20:14,424 --> 01:20:16,292
OTHER OUT THERE HAS READ THE

1866
01:20:16,292 --> 01:20:21,097
PAPER, I FORGET WHICH YEAR,

1867
01:20:21,097 --> 01:20:26,669
MAYBE 2020, MAYBE 2021, FIRST

1868
01:20:26,669 --> 01:20:29,205
SHORE IS ELLE LETT, IN

1869
01:20:29,205 --> 01:20:31,074
PubMed, I HAVE IT -- EVERY

1870
01:20:31,074 --> 01:20:33,676
TIME I SEARCH FOR IT IN MY

1871
01:20:33,676 --> 01:20:35,411
GOOGLE IT SHOWS ME I'VE SEARCHED

1872
01:20:35,411 --> 01:20:37,514
FOR IT PROBABLY A MILLION TIMES

1873
01:20:37,514 --> 01:20:42,418
SO IT LEADS ME RIGHT THERE.

1874
01:20:42,418 --> 01:20:46,256
BUT IT SORT OF DESCRIBES WHAT

1875
01:20:46,256 --> 01:20:49,225
HAPPENS WHEN PEOPLE WHO ARE SORT

1876
01:20:49,225 --> 01:20:53,163
OF, YOU KNOW, NOT EXPERTS IN

1877
01:20:53,163 --> 01:20:56,900
HEALTH EQUITY RESEARCH FOR

1878
01:20:56,900 --> 01:20:58,635
WHATEVER REASON DECIDE TO OR

1879
01:20:58,635 --> 01:21:00,937
HAVE THE OPPORTUNITY TO DO

1880
01:21:00,937 --> 01:21:04,007
RESEARCH IN POPULATIONS THAT

1881
01:21:04,007 --> 01:21:05,675
EXPERIENCE HEALTH DISPARITIES.

1882
01:21:05,675 --> 01:21:13,750
THAT THERE IS -- THERE CAN BE A

1883
01:21:13,750 --> 01:21:17,520
PROCESS OF SORT OF BIAS THAT

1884
01:21:17,520 --> 01:21:20,890
OCCURS WITH THAT.

1885
01:21:20,890 --> 01:21:29,699
ALSO SORT OF A DISSOLUTION OF

1886
01:21:29,699 --> 01:21:32,135
PRINCIPLES OF HEALTH EQUITY THAT

1887
01:21:32,135 --> 01:21:32,769
MAINTAIN TRUSTING RELATIONSHIPS

1888
01:21:32,769 --> 01:21:34,871
WITH COMMUNITIES THAT EXPERIENCE

1889
01:21:34,871 --> 01:21:37,140
DISPARITIES IN HEALTH.

1890
01:21:37,140 --> 01:21:38,808
AND SO IN PART, I ENCOURAGE YOU

1891
01:21:38,808 --> 01:21:41,878
TO READ IT BECAUSE IT'S AN

1892
01:21:41,878 --> 01:21:42,645
EXCELLENT DEFINITION OF HEALTH

1893
01:21:42,645 --> 01:21:47,917
EQUITY TOUR ISM BUT FOUR OR FIVE

1894
01:21:47,917 --> 01:21:51,487
PRINCIPLES THAT HELP US

1895
01:21:51,487 --> 01:21:53,623
UNDERSTAND WHAT IS GOOD HEALTH

1896
01:21:53,623 --> 01:21:56,226
EQUITY RESEARCH.

1897
01:21:56,226 --> 01:22:02,165
PART OF THAT IS COMMUNITY

1898
01:22:02,165 --> 01:22:02,498
PARTNERSHIPS.

1899
01:22:02,498 --> 01:22:04,367
THAT IS WHAT DR. DURANTE -- THAT

1900
01:22:04,367 --> 01:22:07,637
WAS THE CORE MESSAGE OF HER TALK

1901
01:22:07,637 --> 01:22:09,939
AS WELL.

1902
01:22:09,939 --> 01:22:12,875
YOU KNOW, ESSENTIALLY SHE -- DR.

1903
01:22:12,875 --> 01:22:15,311
DURANT AND ELLE LETT ARE TALKING

1904
01:22:15,311 --> 01:22:19,015
ABOUT THE SAME PROCESS, WHICH IS

1905
01:22:19,015 --> 01:22:23,419
HOW DO WE CREATE A SUSTAINABLE

1906
01:22:23,419 --> 01:22:26,222
PARTNERSHIP WITH COMMUNITIES IN

1907
01:22:26,222 --> 01:22:31,394
ORDER TO CONDUCT THE VERY BEST

1908
01:22:31,394 --> 01:22:33,062
RESEARCH IN THESE COMMUNITIES,

1909
01:22:33,062 --> 01:22:35,698
THAT THAT IS INCLUSIVE, THAT

1910
01:22:35,698 --> 01:22:38,534
DOES ADDRESS HEALTH DISPARITIES.

1911
01:22:38,534 --> 01:22:40,303
AND SO I THOUGHT THAT EVEN

1912
01:22:40,303 --> 01:22:42,138
THOUGH SHE SAID SHE HASN'T READ

1913
01:22:42,138 --> 01:22:44,674
THE PAPER THERE REALLY, YOU

1914
01:22:44,674 --> 01:22:48,711
KNOW, A LOT OF COMMONALITIES

1915
01:22:48,711 --> 01:22:50,246
ACROSS THE TWO.

1916
01:22:50,246 --> 01:22:51,214
>> THANK YOU.

1917
01:22:51,214 --> 01:22:53,850
THANK YOU FOR THAT, DR. MANLY.

1918
01:22:53,850 --> 01:22:55,184
ARE THERE ANY QUESTIONS FROM THE

1919
01:22:55,184 --> 01:22:55,852
COUNCIL MEMBERS?

1920
01:22:55,852 --> 01:22:58,154
COMMENTS?

1921
01:22:58,154 --> 01:23:01,758
 

1922
01:23:01,758 --> 01:23:04,060
>> THERE WAS A LOT OF
DISCUSSION

1923
01:23:04,060 --> 01:23:05,361
AFTER YOU MADE THAT.

1924
01:23:05,361 --> 01:23:08,197
I HAD NEVER HEARD OF THE TERM

1925
01:23:08,197 --> 01:23:08,965
HEALTH EQUITY TOURISM.

1926
01:23:08,965 --> 01:23:13,569
BUT ONE OF THE THINGS THAT WE

1927
01:23:13,569 --> 01:23:14,270
WERE DISCUSSING WAS HOW IN

1928
01:23:14,270 --> 01:23:16,105
SCIENCE WE ALL WANT TO GET

1929
01:23:16,105 --> 01:23:17,507
GRANTS, ALL WANT TO BE FUNDED,

1930
01:23:17,507 --> 01:23:22,979
ALL WANT TO WRITE PAPERS.

1931
01:23:22,979 --> 01:23:24,714
GRAPH STATE TO TO THINGS THAT

1932
01:23:24,714 --> 01:23:26,115
YOU CAN GET FUNDING ON.

1933
01:23:26,115 --> 01:23:29,419
IT DOESN'T MEAN THEY ARE ILL

1934
01:23:29,419 --> 01:23:29,719
INTENTIONED.

1935
01:23:29,719 --> 01:23:31,454
BUT IT MEANS YOU GET PEOPLE, AND

1936
01:23:31,454 --> 01:23:33,256
THIS HAS HAPPENED IN THE A.D.

1937
01:23:33,256 --> 01:23:35,558
WORLD IN GENERAL, PEOPLE IN

1938
01:23:35,558 --> 01:23:37,260
DIFFERENT AREAS COMING IN AND

1939
01:23:37,260 --> 01:23:39,595
THEY KNOW NOTHING, THEY HAVE

1940
01:23:39,595 --> 01:23:40,963
THEIR FAVORITE THING THEY DO AND

1941
01:23:40,963 --> 01:23:43,566
THEY THINK THEY CAN GET FUNDED

1942
01:23:43,566 --> 01:23:45,301
IN THE ALZHEIMER'S WORLD.

1943
01:23:45,301 --> 01:23:49,672
IT BEHOOVES US TO FIGURE OUT HOW

1944
01:23:49,672 --> 01:23:53,276
CAN WE EDUCATE PEOPLE WHO ARE

1945
01:23:53,276 --> 01:23:55,778
OPEN, I THINK OPEN, TO HELPING

1946
01:23:55,778 --> 01:23:56,879
OTHER AREAS.

1947
01:23:56,879 --> 01:23:59,015
YOU KNOW, HELPING IN DIFFERENT

1948
01:23:59,015 --> 01:23:59,315
DIRECTIONS.

1949
01:23:59,315 --> 01:24:01,050
AND I THINK MOST OF US DON'T

1950
01:24:01,050 --> 01:24:02,785
WANT TO HURT OR DO ANYTHING

1951
01:24:02,785 --> 01:24:04,220
WRONG BUT WE MIGHT NOT KNOW THE

1952
01:24:04,220 --> 01:24:09,125
BEST WAY OF DOING THINGS.

1953
01:24:09,125 --> 01:24:11,661
FOR PEOPLE FOR INSTANCE IN

1954
01:24:11,661 --> 01:24:12,395
RESEARCH FROM CARDIOLOGY, ASK

1955
01:24:12,395 --> 01:24:13,730
WHAT ALZHEIMER'S IS, WHAT THEY

1956
01:24:13,730 --> 01:24:17,266
WANT TO DO, I FEEL LIKE WE HAVE

1957
01:24:17,266 --> 01:24:21,838
TO AS A COMMUNITY, AS IT GROWS,

1958
01:24:21,838 --> 01:24:22,872
EDUCATE AND DIRECT PEOPLE.

1959
01:24:22,872 --> 01:24:24,607
WE DON'T HAVE A LOT OF TIME TO

1960
01:24:24,607 --> 01:24:25,141
DO THAT.

1961
01:24:25,141 --> 01:24:27,009
AND WE'RE NOT ALWAYS GOOD AT

1962
01:24:27,009 --> 01:24:29,312
DOING IT.

1963
01:24:29,312 --> 01:24:34,717
BUT HOW CAN WE MOVE PEOPLE WHO 

1964
01:24:34,717 --> 01:24:36,486
ARE, QUOTE, TOURISTS WHO ARE --

1965
01:24:36,486 --> 01:24:40,289
THEIR INTENTION IS NOT NEGATIVE

1966
01:24:40,289 --> 01:24:42,392
BUT -- I DON'T THINK -- TO

1967
01:24:42,392 --> 01:24:44,026
UNDERSTAND WHAT THEY NEED TO DO

1968
01:24:44,026 --> 01:24:46,629
IN THE COMMUNITIES TO NOT BE

1969
01:24:46,629 --> 01:24:53,569
DETRIMENTAL. 

1970
01:24:53,569 --> 01:24:55,304
>> I'VE THOUGHT ABOUT THAT
A

1971
01:24:55,304 --> 01:24:59,375
LOT, AND I THINK THAT THERE'S

1972
01:24:59,375 --> 01:25:02,445
TWO THINGS THAT I -- JUST AS NIA

1973
01:25:02,445 --> 01:25:05,181
COUNCIL, WE CAN THINK ABOUT,

1974
01:25:05,181 --> 01:25:12,622
WHICH IS ONE IS WHEN WE HAVE

1975
01:25:12,622 --> 01:25:15,591
CONCEPT CLEARANCES THAT

1976
01:25:15,591 --> 01:25:17,126
ESPECIALLY IF THE CORE PART, AND

1977
01:25:17,126 --> 01:25:20,396
IT SHOULD BE A CORE PART OF MANY

1978
01:25:20,396 --> 01:25:23,866
OF THEM, IS TO ADDRESS

1979
01:25:23,866 --> 01:25:24,867
DISPARITIES IN WHATEVER THE --

1980
01:25:24,867 --> 01:25:29,338
YOU KNOW, OUTCOME IS, IT COULD

1981
01:25:29,338 --> 01:25:31,207
BE ADRD, YOU MENTIONED THAT

1982
01:25:31,207 --> 01:25:33,943
BEING FREQUENTLY MENTIONED IN

1983
01:25:33,943 --> 01:25:38,648
CONCEPT CLEARANCES, BUT IF

1984
01:25:38,648 --> 01:25:39,749
ADDRESSING DISPARITIES OR

1985
01:25:39,749 --> 01:25:41,717
INCLUDING POPULATIONS THAT

1986
01:25:41,717 --> 01:25:44,287
AREN'T TRADITIONALLY INVITED TO

1987
01:25:44,287 --> 01:25:47,290
BE IN RESEARCH IS PART OF THE

1988
01:25:47,290 --> 01:25:50,893
GOAL, THEN ANOTHER PART OF BEING

1989
01:25:50,893 --> 01:25:53,162
RESPONSIVE TO THAT APPLICATION

1990
01:25:53,162 --> 01:25:56,132
COULD BE EXPERTISE IN THE

1991
01:25:56,132 --> 01:25:57,900
LEADERSHIP OF THAT APPLICATION

1992
01:25:57,900 --> 01:25:59,969
IN HEALTH EQUITY.

1993
01:25:59,969 --> 01:26:01,504
PROVEN EXPERTISE IN HEALTH

1994
01:26:01,504 --> 01:26:01,737
EQUITY.

1995
01:26:01,737 --> 01:26:04,574
SO WHAT THAT MEANS IS NOT

1996
01:26:04,574 --> 01:26:08,511
NECESSARILY ALWAYS TRYING TO

1997
01:26:08,511 --> 01:26:10,813
RETOOL, YOU KNOW, THE NETWORK,

1998
01:26:10,813 --> 01:26:12,782
YOU KNOW, THE NETWORK OF PEOPLE

1999
01:26:12,782 --> 01:26:15,852
WHO TRADITIONALLY RESPOND TO

2000
01:26:15,852 --> 01:26:17,186
THESE APPLICATIONS.

2001
01:26:17,186 --> 01:26:19,021
ALTHOUGH THAT COULD BE CERTAINLY

2002
01:26:19,021 --> 01:26:21,958
A KEY PART OF WHAT NIA DOES IN

2003
01:26:21,958 --> 01:26:23,960
ITS TRAINING, TRAINING ACROSS

2004
01:26:23,960 --> 01:26:25,161
THE CAREER LEVEL, THAT IF WE'RE

2005
01:26:25,161 --> 01:26:30,533
GOING TO REALLY BE A MORE

2006
01:26:30,533 --> 01:26:31,200
INCLUSIVE SCIENCE OF AGING,

2007
01:26:31,200 --> 01:26:33,035
THAT, YOU KNOW, WE HAVE TO MAKE

2008
01:26:33,035 --> 01:26:35,571
SURE PEOPLE HAVE THE

2009
01:26:35,571 --> 01:26:37,373
RECOGNITION, YOU KNOW, RECOGNIZE

2010
01:26:37,373 --> 01:26:39,509
WHAT THAT MEANS, WHAT THE

2011
01:26:39,509 --> 01:26:42,345
PRINCIPLES ARE OF HEALTH EQUITY.

2012
01:26:42,345 --> 01:26:44,313
AND SO THAT'S ONE PIECE.

2013
01:26:44,313 --> 01:26:45,281
THE OTHER PIECE IS SOME OF US

2014
01:26:45,281 --> 01:26:47,149
ARE NEVER GOING TO REACH THE

2015
01:26:47,149 --> 01:26:49,218
LEVEL OF BEING AN EXPERT IN THE

2016
01:26:49,218 --> 01:26:50,987
SCIENCE OF INCLUSION.

2017
01:26:50,987 --> 01:26:53,155
IT'S JUST NOT THE CORE PART OF

2018
01:26:53,155 --> 01:26:54,190
WHAT WE DO.

2019
01:26:54,190 --> 01:26:57,093
AND SO WE NEED TO PARTNER WITH

2020
01:26:57,093 --> 01:26:59,195
EXPERTS AND THAT PARTNERSHIP HAS

2021
01:26:59,195 --> 01:27:01,397
TO BE AN EQUAL ONE.

2022
01:27:01,397 --> 01:27:04,567
AND THAT MEANS LEADERSHIP, NOT

2023
01:27:04,567 --> 01:27:10,006
JUST A -- YOU KNOW, SORT OF A

2024
01:27:10,006 --> 01:27:11,440
SUPERFICIAL PIECE OF THE, YOU

2025
01:27:11,440 --> 01:27:13,843
KNOW, LEADING THE EDUCATION

2026
01:27:13,843 --> 01:27:14,710
OUTREACH CORE.

2027
01:27:14,710 --> 01:27:17,146
YOU KNOW, THAT'S NOT THE ONLY

2028
01:27:17,146 --> 01:27:18,881
ROLE THAT WE HAVE.

2029
01:27:18,881 --> 01:27:23,553
AND SO WHAT I'M SAYING IS THAT,

2030
01:27:23,553 --> 01:27:25,221
YOU KNOW, I'M HOPING THAT MORE

2031
01:27:25,221 --> 01:27:29,025
IN THE FUTURE, I'VE LEARNED THIS

2032
01:27:29,025 --> 01:27:31,761
FROM PROGRAM OFFICERS HERE, THAT

2033
01:27:31,761 --> 01:27:38,334
THERE MAY BE ADDITIONAL WAYS TO

2034
01:27:38,334 --> 01:27:40,503
ENCOURAGE AND TO HARD CODE INTO

2035
01:27:40,503 --> 01:27:43,472
THE APPLICATIONS THAT ARE

2036
01:27:43,472 --> 01:27:53,983
RESPONSIVE THIS HEALTH EQUITY

2037
01:27:58,421 --> 01:27:58,821
EXPERTISE.

2038
01:27:58,821 --> 01:27:59,689
>> THANK YOU, GREAT POINT.

2039
01:27:59,689 --> 01:28:01,390
>> AS PART OF THE
PARTNERSHIP

2040
01:28:01,390 --> 01:28:03,492
YOU ALLUDED TO, DR. MANLY, I

2041
01:28:03,492 --> 01:28:05,027
THINK FOR EXAMPLE THE TRAINING

2042
01:28:05,027 --> 01:28:08,130
PROGRAMS THAT WE HAVE LIKE THE

2043
01:28:08,130 --> 01:28:11,000
K22, THEY SHOULD BE LOOKING TO

2044
01:28:11,000 --> 01:28:12,368
THE NON-PROFIT SECTOR, FOR

2045
01:28:12,368 --> 01:28:12,602
EXAMPLE.

2046
01:28:12,602 --> 01:28:13,703
I ASKED THAT QUESTION YESTERDAY,

2047
01:28:13,703 --> 01:28:16,439
WHAT IS THE ROLE OF THE

2048
01:28:16,439 --> 01:28:17,940
NON-PROFIT SECTOR IN THIS.

2049
01:28:17,940 --> 01:28:20,376
THERE'S A HUGE ROLE THE

2050
01:28:20,376 --> 01:28:21,777
NON-PROFIT SECTOR CAN PLAY.

2051
01:28:21,777 --> 01:28:24,313
THERE'S TRUST WITHIN THIS

2052
01:28:24,313 --> 01:28:24,680
SECTOR.

2053
01:28:24,680 --> 01:28:26,616
THERE'S THE YOUNG POPULATION IS

2054
01:28:26,616 --> 01:28:27,817
CONNECTED, FAMILIES ARE

2055
01:28:27,817 --> 01:28:29,485
CONNECTED TO THESE SECTORS.

2056
01:28:29,485 --> 01:28:32,922
WE'RE LEAVING OUT A HUGE

2057
01:28:32,922 --> 01:28:33,222
OPPORTUNITY.

2058
01:28:33,222 --> 01:28:36,492
SO I INVITE ALL OF US TO THINK

2059
01:28:36,492 --> 01:28:40,796
ABOUT HOW CAN WE INCORPORATE THE

2060
01:28:40,796 --> 01:28:41,697
NON-PROFIT SECTOR IN ORDER TO,

2061
01:28:41,697 --> 01:28:45,067
YOU KNOW, TO BE MORE INCLUSIVE

2062
01:28:45,067 --> 01:28:46,836
OF POPULATIONS THAT ARE OFTEN

2063
01:28:46,836 --> 01:28:49,972
NOT INCLUDED.

2064
01:28:49,972 --> 01:28:50,106
 

2065
01:28:50,106 --> 01:28:54,010
SO WITH THAT, --

2066
01:28:54,010 --> 01:28:55,578
>> A COUPLE QUESTIONS.

2067
01:28:55,578 --> 01:28:57,213
>> I JUST WANTED TO FOLLOW
UP ON

2068
01:28:57,213 --> 01:29:00,816
WHAT DR. MANLY JUST SAID.

2069
01:29:00,816 --> 01:29:03,219
REALLY AGREE WITH HER.

2070
01:29:03,219 --> 01:29:05,988
NOW, THE ISSUE FOR THE ADRCs

2071
01:29:05,988 --> 01:29:07,089
FOR CENTER PROGRAM, OF COURSE

2072
01:29:07,089 --> 01:29:12,128
IT'S A DECISION BY THE NIA AND

2073
01:29:12,128 --> 01:29:14,530
THE CENTER DIRECTORS ON THE

2074
01:29:14,530 --> 01:29:17,800
ADMINISTRATION SIDE, THERE ARE

2075
01:29:17,800 --> 01:29:19,135
SOME ADRCs THAT HAVE A FULL

2076
01:29:19,135 --> 01:29:22,872
CORE WHICH IS DEDICATED TO

2077
01:29:22,872 --> 01:29:23,506
RECRUITING PARTICIPANTS FROM

2078
01:29:23,506 --> 01:29:25,174
UNDERREPRESENTED GROUPS.

2079
01:29:25,174 --> 01:29:29,311
WE HAVE ONE IN WISCONSIN,

2080
01:29:29,311 --> 01:29:30,513
WashU AND OTHER ADRCs THAT

2081
01:29:30,513 --> 01:29:32,381
HAVE FULL CORES TO DO THAT.

2082
01:29:32,381 --> 01:29:33,816
IT'S BEEN VERY SUCCESSFUL, I CAN

2083
01:29:33,816 --> 01:29:36,552
TELL YOU, FROM OUR EXPERIENCE IN

2084
01:29:36,552 --> 01:29:36,819
WISCONSIN.

2085
01:29:36,819 --> 01:29:40,389
THE ISSUE HERE IS COULD THAT BE

2086
01:29:40,389 --> 01:29:44,794
A MANDATORY CORE AND IF SO THEN

2087
01:29:44,794 --> 01:29:46,862
THAT COURSE BUDGET HAS TO COME

2088
01:29:46,862 --> 01:29:49,065
FROM EXISTING BUDGET WHICH MAKES

2089
01:29:49,065 --> 01:29:51,233
IT DIFFICULT BECAUSE MOST OF THE

2090
01:29:51,233 --> 01:29:52,535
CENTERS HAVE MANY CORES WHICH

2091
01:29:52,535 --> 01:29:54,937
ARE MANDATORY.

2092
01:29:54,937 --> 01:29:58,140
I MEAN, FOR US IT'S VERY

2093
01:29:58,140 --> 01:29:59,108
IMPORTANT.

2094
01:29:59,108 --> 01:30:00,443
IT'S REALLY PROGRAM'S DECISION

2095
01:30:00,443 --> 01:30:04,113
WHETHER SUCH A CORE COULD BE

2096
01:30:04,113 --> 01:30:05,915
MADE MANDATORY OR IN THE RFA

2097
01:30:05,915 --> 01:30:08,851
THAT THEY HAVE TO AT MINIMUM

2098
01:30:08,851 --> 01:30:10,920
DEMONSTRATE THERE'S A PERSON

2099
01:30:10,920 --> 01:30:12,922
WITH ACKNOWLEDGED AND

2100
01:30:12,922 --> 01:30:13,856
DEMONSTRATED EXPERTISE IN THIS

2101
01:30:13,856 --> 01:30:15,925
AREA, WHO SHOULD BE IN THE

2102
01:30:15,925 --> 01:30:17,626
LEADERSHIP STRUCTURE OF THE

2103
01:30:17,626 --> 01:30:18,594
ADRC.

2104
01:30:18,594 --> 01:30:20,463
BUT I THINK IT'S A CRITICAL

2105
01:30:20,463 --> 01:30:27,570
POINT, WE REALLY HAVE INTERN --

2106
01:30:27,570 --> 01:30:31,607
BENEFITED, DR. GLEASON LEADS IT,

2107
01:30:31,607 --> 01:30:32,374
IT'S BEEN VERY SUCCESSFUL, THINK

2108
01:30:32,374 --> 01:30:34,477
ABOUT HOW IT COULD BE DONE

2109
01:30:34,477 --> 01:30:35,144
ACROSS THE CENTER'S PROGRAM.

2110
01:30:35,144 --> 01:30:41,817
>> THANK YOU. 

2111
01:30:41,817 --> 01:30:45,421
>> NOW FOR SOMETHING
COMPLETELY

2112
01:30:45,421 --> 01:30:45,688
DIFFERENT.

2113
01:30:45,688 --> 01:30:50,993
SO, IF WE WANT TO CREATE A TRUST

2114
01:30:50,993 --> 01:30:53,496
BETWEEN RESEARCH ENTERPRISE AND

2115
01:30:53,496 --> 01:30:54,063
UNDERSERVED MINORITY

2116
01:30:54,063 --> 01:30:55,898
COMMUNITIES, THERE'S ONE VERY

2117
01:30:55,898 --> 01:30:58,868
IMPORTANT ASPECT OF IT WHICH

2118
01:30:58,868 --> 01:31:00,636
ALMOST NEVER OCCURS.

2119
01:31:00,636 --> 01:31:03,005
I HAVE NIH GRANTS.

2120
01:31:03,005 --> 01:31:05,641
THE RPPR THAT I CREATE, THERE'S

2121
01:31:05,641 --> 01:31:07,610
A PLACE FOR PUBLIC

2122
01:31:07,610 --> 01:31:08,344
DISSEMINATION.

2123
01:31:08,344 --> 01:31:12,882
BUT WHAT THEY REALLY WANT TO

2124
01:31:12,882 --> 01:31:14,850
KNOW, PUBLICATION, HIGH-IMPACT

2125
01:31:14,850 --> 01:31:16,819
JOURNALS, WHAT KIND OF -- AND

2126
01:31:16,819 --> 01:31:20,089
PRESENTATION, THAT SORT OF

2127
01:31:20,089 --> 01:31:20,923
THING.

2128
01:31:20,923 --> 01:31:23,726
BUT THERE'S NO PLACE OR THE

2129
01:31:23,726 --> 01:31:25,427
RESEARCHERS ARE NEVER ENCOURAGED

2130
01:31:25,427 --> 01:31:27,096
TO ACTUALLY ASK THE SIMPLE

2131
01:31:27,096 --> 01:31:30,733
QUESTION, DID YOU DO ANY

2132
01:31:30,733 --> 01:31:33,135
PRESENTATION TO THE COMMUNITY

2133
01:31:33,135 --> 01:31:36,305
WHO CONTRIBUTED TO THE

2134
01:31:36,305 --> 01:31:37,072
DISCOVERY?

2135
01:31:37,072 --> 01:31:40,576
IF YOU ASK THAT, RESEARCHER WILL

2136
01:31:40,576 --> 01:31:41,477
DO IT.

2137
01:31:41,477 --> 01:31:43,112
BUT THAT NEVER HAPPENS.

2138
01:31:43,112 --> 01:31:46,715
I'VE NOT SEEN IT YET.

2139
01:31:46,715 --> 01:31:51,320
SO, IN MY OPINION, GIVING THE 

2140
01:31:51,320 --> 01:31:52,421
FEEDBACK TO THE COMMUNITY WHO

2141
01:31:52,421 --> 01:31:53,956
CONTRIBUTED TO THE SCIENCE IS A

2142
01:31:53,956 --> 01:31:55,691
REALLY BIG DEAL.

2143
01:31:55,691 --> 01:32:01,730
AND I THINK IT COULD BE FOR OUR

2144
01:32:01,730 --> 01:32:03,032
CASE, THEY DO COMMUNITY

2145
01:32:03,032 --> 01:32:03,666
GATHERINGS.

2146
01:32:03,666 --> 01:32:05,568
YOU CAN GO THERE AND TALK ABOUT

2147
01:32:05,568 --> 01:32:06,302
IT.

2148
01:32:06,302 --> 01:32:08,737
HEY, WE DID THIS, THESE ARE THE

2149
01:32:08,737 --> 01:32:09,071
FINDINGS.

2150
01:32:09,071 --> 01:32:13,008
BEFORE SOMEBODY LISTENS TO THAT

2151
01:32:13,008 --> 01:32:16,078
IN IPHA MEETING WHICH HAS

2152
01:32:16,078 --> 01:32:16,612
OCCURRED.

2153
01:32:16,612 --> 01:32:17,680
EVEN BEFORE CHEROKEES KNEW WHAT

2154
01:32:17,680 --> 01:32:19,915
WAS FOUND IT WAS IN A PAPER,

2155
01:32:19,915 --> 01:32:22,651
SOME PRESENTATION IN NEW YORK.

2156
01:32:22,651 --> 01:32:27,456
I WAS IN THAT AUDIENCE.

2157
01:32:27,456 --> 01:32:28,424
SO COMMUNITY SUMMARY, THERE'S A

2158
01:32:28,424 --> 01:32:31,060
NUMBER OF WAYS YOU CAN

2159
01:32:31,060 --> 01:32:34,997
COMMUNICATE WITH, YOU KNOW,

2160
01:32:34,997 --> 01:32:35,764
UNDERSERVED MINORITIES, AND I

2161
01:32:35,764 --> 01:32:40,269
THINK THAT'S A PART BY AND LARGE

2162
01:32:40,269 --> 01:32:42,905
MY EXPERIENCE HAS BEEN MISSED.

2163
01:32:42,905 --> 01:32:44,206
IF WE START THERE, SOME OF THE

2164
01:32:44,206 --> 01:32:47,376
-- YOU KNOW, THE THINGS THAT WE

2165
01:32:47,376 --> 01:32:48,244
HEARD, ISSUES YESTERDAY, YOU

2166
01:32:48,244 --> 01:32:50,012
KNOW, LACK OF TRUST, ALL THAT

2167
01:32:50,012 --> 01:32:51,881
STUFF, PROBABLY WILL GO AWAY AT

2168
01:32:51,881 --> 01:32:56,018
SOME POINT. 

2169
01:32:56,018 --> 01:32:56,719
>> VERY GOOD.

2170
01:32:56,719 --> 01:32:57,519
THANK YOU.

2171
01:32:57,519 --> 01:32:59,421
THANK YOU FOR THOSE COMMENTS.

2172
01:32:59,421 --> 01:33:04,293
I THINK WE'LL NEED TO MOVE ON.

2173
01:33:04,293 --> 01:33:12,001
THANK YOU, DOCTORS CRUZ AND

2174
01:33:12,001 --> 01:33:13,302
SCHNEIDER.

2175
01:33:13,302 --> 01:33:15,404
>> ONE POINT, THE
MANUSCRIPT DR.

2176
01:33:15,404 --> 01:33:16,906
MANLY CITED, I SHARED THAT WITH

2177
01:33:16,906 --> 01:33:18,440
JASMINE AND SHE WILL POST IT IN

2178
01:33:18,440 --> 01:33:19,875
COUNCIL BOOKS TO SEE AND READ

2179
01:33:19,875 --> 01:33:22,378
THE DEFINITION.

2180
01:33:22,378 --> 01:33:23,145
>> YES.

2181
01:33:23,145 --> 01:33:25,214
THANK YOU.

2182
01:33:25,214 --> 01:33:27,650
NEXT UP WE HAD OUR WORKING GROUP

2183
01:33:27,650 --> 01:33:28,350
ON PROGRAM.

2184
01:33:28,350 --> 01:33:30,920
I'LL TURN IT OVER TO THE CHAIR,

2185
01:33:30,920 --> 01:33:35,858
DR. SUSAN GREENSPAN.

2186
01:33:35,858 --> 01:33:36,158
SUSAN?

2187
01:33:36,158 --> 01:33:37,693
>> THANK YOU, KEN.

2188
01:33:37,693 --> 01:33:41,463
WE HAD ONE CONTRACT THAT HAD

2189
01:33:41,463 --> 01:33:43,899
THREE PARTS.

2190
01:33:43,899 --> 01:33:46,635
MODELING AGING THROUGH

2191
01:33:46,635 --> 01:33:47,703
MICROPHYSIOLOGICAL SYSTEMS,

2192
01:33:47,703 --> 01:33:48,804
SECOND PART DIGITAL TECHNOLOGIES

2193
01:33:48,804 --> 01:33:52,074
AS TOOLS TO SCREEN AND MONITOR

2194
01:33:52,074 --> 01:33:53,509
ALZHEIMER'S DISEASE AND RELATED

2195
01:33:53,509 --> 01:33:57,446
DEMENTIAS, AND THE THIRD PART

2196
01:33:57,446 --> 01:33:58,113
LEVERAGING MULTI-MODAL AND

2197
01:33:58,113 --> 01:33:58,981
GENERATEIVE ARTIFICIAL

2198
01:33:58,981 --> 01:34:01,050
INTELLIGENCE TO ADVANCE THE

2199
01:34:01,050 --> 01:34:02,818
APPLICATION OF SOCIAL ROBOTICS

2200
01:34:02,818 --> 01:34:04,787
IN CAREGIVING.

2201
01:34:04,787 --> 01:34:07,189
THE PRIMARY REVIEWER WAS DR.

2202
01:34:07,189 --> 01:34:12,127
HUANG, SECOND WAS DR. REUBEN.

2203
01:34:12,127 --> 01:34:13,228
DR. HUANG, PLEASE BRIEFLY

2204
01:34:13,228 --> 01:34:16,732
COMMENT, GIVE US A SUMMARY OF

2205
01:34:16,732 --> 01:34:21,303
THE PROPOSAL AND COMMENTS.

2206
01:34:21,303 --> 01:34:23,405
>> YES, THANK YOU.

2207
01:34:23,405 --> 01:34:26,809
THIS CONTRACT CLEARANCE COVERS

2208
01:34:26,809 --> 01:34:28,344
THREE TOPICS.

2209
01:34:28,344 --> 01:34:31,780
ALL THREE TOPICS WERE DISCUSSED

2210
01:34:31,780 --> 01:34:34,583
AND APPROVED BY SMALL BUSINESS

2211
01:34:34,583 --> 01:34:35,918
COMMITTEE, PEOPLE COME, JUST

2212
01:34:35,918 --> 01:34:38,520
GIVE A BRIEF SUMMARY OF THE

2213
01:34:38,520 --> 01:34:38,854
DISCUSSION.

2214
01:34:38,854 --> 01:34:45,527
FIRST ONE IS THE MODELING

2215
01:34:45,527 --> 01:34:46,962
MICROPHYSIOLOGICAL SYSTEM.

2216
01:34:46,962 --> 01:34:49,031
MAJORITY OF RESEARCH

2217
01:34:49,031 --> 01:34:49,898
INVESTIGATING BIOLOGICAL

2218
01:34:49,898 --> 01:34:51,533
MECHANISM UNDERLYING NORMAL

2219
01:34:51,533 --> 01:34:54,069
AGING PROCESS AND AGING-RELATED

2220
01:34:54,069 --> 01:34:56,905
DISEASE HAS BEEN CONDUCTED USING

2221
01:34:56,905 --> 01:35:00,309
CULTURES AND MODELS, MANY YEARS,

2222
01:35:00,309 --> 01:35:01,944
THAT ONLY PARTIALLY RECAPITULATE

2223
01:35:01,944 --> 01:35:06,548
AGING IN HUMANS.

2224
01:35:06,548 --> 01:35:10,486
SO THIS SBRR CONTRACT SOLICITED

2225
01:35:10,486 --> 01:35:12,454
A NEW SYSTEM CALLED

2226
01:35:12,454 --> 01:35:14,089
MICROPHYSIOLOGICAL SYSTEM, WHICH

2227
01:35:14,089 --> 01:35:16,191
ARE THREE DIMENSIONAL HUMAN

2228
01:35:16,191 --> 01:35:19,595
TISSUE CULTURAL CONSTRUCTS, TO

2229
01:35:19,595 --> 01:35:21,997
MIMIC BETTER HUMAN TISSUE, COULD

2230
01:35:21,997 --> 01:35:23,766
PROVIDE MORE TRANSLATION ON

2231
01:35:23,766 --> 01:35:26,035
RELEVANT AND COST EFFECTIVE

2232
01:35:26,035 --> 01:35:28,704
MODELS TO SUPPLEMENT OR EVEN

2233
01:35:28,704 --> 01:35:32,174
REPLACE 2D CELL CULTURE AND IN

2234
01:35:32,174 --> 01:35:34,243
SOME CASES ANIMAL MODELS, IN AGE

2235
01:35:34,243 --> 01:35:38,213
AND RESEARCH AND DIRECTIVE ON

2236
01:35:38,213 --> 01:35:38,981
THAT.

2237
01:35:38,981 --> 01:35:41,817
SHORT-TERM GOAL IS CONTRACT TO

2238
01:35:41,817 --> 01:35:45,320
ESTABLISH MPS, SPECIAL TERM OF

2239
01:35:45,320 --> 01:35:47,823
THIS MICROPHYSIOLOGIC SYSTEM, AS

2240
01:35:47,823 --> 01:35:48,924
A STANDARDIZED TOOL FOR

2241
01:35:48,924 --> 01:35:51,427
DISCOVERY SCIENCE OR DRUG

2242
01:35:51,427 --> 01:35:57,366
DEVELOPMENT, AGING RESEARCH. 

2243
01:35:57,366 --> 01:35:59,635
SO, THIS LONG-TERM GOAL IS

2244
01:35:59,635 --> 01:36:03,472
FURTHER IMPLEMENTATION OF MPS AS

2245
01:36:03,472 --> 01:36:05,674
FDA QUALIFIED DRUG DEVELOPMENT

2246
01:36:05,674 --> 01:36:06,408
TOOL, IN FUTURE.

2247
01:36:06,408 --> 01:36:09,278
THIS IS A FIRST.

2248
01:36:09,278 --> 01:36:12,681
THE SECOND TOPIC IS DIGITAL

2249
01:36:12,681 --> 01:36:13,982
TECHNOLOGIES AS TOOLS TO SCREEN

2250
01:36:13,982 --> 01:36:21,857
AND MONITOR ALZHEIMER'S DISEASE 

2251
01:36:21,857 --> 01:36:24,726
AND RELATED DEMENTIA, LARGELY

2252
01:36:24,726 --> 01:36:27,896
MANAGED SYMPTOM, AND THE DISEASE

2253
01:36:27,896 --> 01:36:31,834
MODIFYING TREATMENT HAVE BECOME

2254
01:36:31,834 --> 01:36:33,268
AVAILABLE ONLY RECENTLY,

2255
01:36:33,268 --> 01:36:35,104
SIGNIFICANT HOW IDENTIFY

2256
01:36:35,104 --> 01:36:36,672
PREVENTED EFFECTIVE MANAGEMENT

2257
01:36:36,672 --> 01:36:41,577
AND TREATMENT OF AD OR ADRD,

2258
01:36:41,577 --> 01:36:44,947
RELATED TO THE SCREENINGS, EARLY

2259
01:36:44,947 --> 01:36:45,514
DETECTION, ENROLLMENT IN

2260
01:36:45,514 --> 01:36:48,150
CLINICAL TRIALS AND MANY OTHERS.

2261
01:36:48,150 --> 01:36:50,452
THERE'S UNMET NEED TO DEVELOP

2262
01:36:50,452 --> 01:36:53,055
NEW TOOLS THAT CAN FILL THESE

2263
01:36:53,055 --> 01:36:53,489
GAPS.

2264
01:36:53,489 --> 01:36:55,791
SO A REASON THAT'S BEEN

2265
01:36:55,791 --> 01:36:57,226
INTERESTING DEVELOPMENT OF

2266
01:36:57,226 --> 01:37:00,729
DEVICE AND DIGITAL TECHNOLOGIES

2267
01:37:00,729 --> 01:37:02,564
TO EVALUATE COGNITIVE

2268
01:37:02,564 --> 01:37:06,835
IMPAIRMENT, AND THOSE DEVICE AND

2269
01:37:06,835 --> 01:37:11,440
TECHNOLOGIES SUCH AS SOFTWARE 

2270
01:37:11,440 --> 01:37:13,842
HAVE ADVANTAGE OF CONSISTENCY IN

2271
01:37:13,842 --> 01:37:15,277
ADMINISTERING TEST AND

2272
01:37:15,277 --> 01:37:17,779
REPRODUCIBILITY OF THOSE

2273
01:37:17,779 --> 01:37:18,547
RESULTS.

2274
01:37:18,547 --> 01:37:20,182
HOWEVER, TO BE UNIVERSALLY

2275
01:37:20,182 --> 01:37:23,719
ACCEPTED THOSE TOOLS NEED TO BE

2276
01:37:23,719 --> 01:37:25,354
STANDARDIZED, VALIDATED IN

2277
01:37:25,354 --> 01:37:29,625
DIVERSE POPULATIONS.

2278
01:37:29,625 --> 01:37:32,661
THIS CONTRACT SUPPORTS NEED FOR

2279
01:37:32,661 --> 01:37:33,996
DEVELOPMENT FOR THOSE TOOLS IN

2280
01:37:33,996 --> 01:37:34,429
USE.

2281
01:37:34,429 --> 01:37:36,965
SO THE GOAL OF THIS CONTRACT

2282
01:37:36,965 --> 01:37:42,304
TOPIC IS TO STIMULATE THE

2283
01:37:42,304 --> 01:37:43,672
PARTICIPATION OF SMALL BUSINESS

2284
01:37:43,672 --> 01:37:46,074
IN THE DEVELOPMENT TOOL PROGRAM.

2285
01:37:46,074 --> 01:37:51,680
AND THIS SECOND, THE LAST ONE IS

2286
01:37:51,680 --> 01:37:52,581
LEVERAGING MULTI-MODAL AND

2287
01:37:52,581 --> 01:37:53,215
GENERATIVE ARTIFICIAL

2288
01:37:53,215 --> 01:37:55,184
INTELLIGENCE TO ADVANCE THE

2289
01:37:55,184 --> 01:37:58,921
APPLICATION OF SOCIAL ROBOTICS

2290
01:37:58,921 --> 01:38:00,222
IN CAREGIVING.

2291
01:38:00,222 --> 01:38:02,291
THERE'S CLEAR BURDEN OF THE

2292
01:38:02,291 --> 01:38:06,228
CAREGIVING FOR A PERSON WITH

2293
01:38:06,228 --> 01:38:08,730
DEMENTIA, ARISING USUALLY FROM

2294
01:38:08,730 --> 01:38:11,166
BOTH PSYCHOLOGICAL AND

2295
01:38:11,166 --> 01:38:14,203
NON-PSYCHOLOGICAL STRESSORS THAT

2296
01:38:14,203 --> 01:38:15,971
IS OVERWHELMING.

2297
01:38:15,971 --> 01:38:19,274
ASSISTIVE TECHNOLOGIES THAT

2298
01:38:19,274 --> 01:38:20,676
ATTENUATE CAREGIVING BURDEN WILL

2299
01:38:20,676 --> 01:38:23,078
BE NEEDED.

2300
01:38:23,078 --> 01:38:24,746
HOWEVER MOST SOLUTIONS ARE

2301
01:38:24,746 --> 01:38:26,148
MOBILE OR WEBSITE-BASED THAT

2302
01:38:26,148 --> 01:38:29,985
HAVE MANY LIMITATIONS.

2303
01:38:29,985 --> 01:38:32,721
THOSE LIMITATIONS REDUCE MEANING

2304
01:38:32,721 --> 01:38:35,891
FOR THOSE PERSONS WITH DEMENTIA

2305
01:38:35,891 --> 01:38:36,225
ENGAGEMENT.

2306
01:38:36,225 --> 01:38:39,394
SO THAT'S WHY THIS MODEL AND

2307
01:38:39,394 --> 01:38:41,029
GENERATIVE A.I. CAN LIKELY

2308
01:38:41,029 --> 01:38:45,067
ADDRESS THE NEED OF TACKLING

2309
01:38:45,067 --> 01:38:47,169
LIMITATIONS, THE BROAD OBJECTIVE

2310
01:38:47,169 --> 01:38:53,642
OF THIS CONTRACT PROPOSAL IS TO

2311
01:38:53,642 --> 01:38:54,209
LEVERAGE MULTI-MODAL AND

2312
01:38:54,209 --> 01:38:58,113
GENERATIVE A.I. TO PROVIDE A NEW

2313
01:38:58,113 --> 01:38:59,881
TOOL TO REVOLUTIONIZE

2314
01:38:59,881 --> 01:39:02,618
APPLICATION OF SOCIAL ROBOTICS

2315
01:39:02,618 --> 01:39:06,622
IN CAREGIVING FOR THOSE PERSONS

2316
01:39:06,622 --> 01:39:08,257
WITH DEMENTIA.

2317
01:39:08,257 --> 01:39:18,367
ALL  THREE SET  ASIDE BECAUSE

2318
01:39:18,367 --> 01:39:20,669
THEY ALL REQUIRE SPECIFIC

2319
01:39:20,669 --> 01:39:24,740
EXPERTISE FOR THE REVIEWING AND

2320
01:39:24,740 --> 01:39:25,841
SUPPORTING.

2321
01:39:25,841 --> 01:39:30,312
AND THOSE TOPICS ALL ADDRESS

2322
01:39:30,312 --> 01:39:33,715
SEVERAL NIA PRIORITIES INCLUDING

2323
01:39:33,715 --> 01:39:36,318
GOALS ABCD AND F, AND IN

2324
01:39:36,318 --> 01:39:37,219
DISCUSSION COUNCIL AGREE THIS IS

2325
01:39:37,219 --> 01:39:42,691
A WELL DESIGNED AND TIMELY

2326
01:39:42,691 --> 01:39:43,892
IMPORTANT MULTI-TOPICS SBRR

2327
01:39:43,892 --> 01:39:45,327
CONTRACT PROPOSALS LOOKING FOR

2328
01:39:45,327 --> 01:39:47,496
SUPPORT.

2329
01:39:47,496 --> 01:39:52,234
 

2330
01:39:52,234 --> 01:39:54,636
>> THANK YOU.

2331
01:39:54,636 --> 01:39:56,738
THAT APPEARS TO BE ENTHUSIASM TO

2332
01:39:56,738 --> 01:39:58,840
MOVE THE PROPOSAL FORWARD.

2333
01:39:58,840 --> 01:40:00,676
CAN WE DO A FORMAL VOTE?

2334
01:40:00,676 --> 01:40:03,612
IS THERE A MOVE TO MOVE THIS

2335
01:40:03,612 --> 01:40:03,845
FORWARD?

2336
01:40:03,845 --> 01:40:05,480
>> SO MOVED.

2337
01:40:05,480 --> 01:40:06,915
>> IS THERE A SECOND?

2338
01:40:06,915 --> 01:40:09,951
ALL THOSE WHO APPROVE IT?

2339
01:40:09,951 --> 01:40:11,053
ANY OPPOSED?

2340
01:40:11,053 --> 01:40:13,188
SO THIS CONCEPT WILL FORMALLY

2341
01:40:13,188 --> 01:40:13,789
MOVE FORWARD.

2342
01:40:13,789 --> 01:40:18,994
THANK YOU. 

2343
01:40:18,994 --> 01:40:23,699
>> THANK YOU, DR.
GREENSPAN.

2344
01:40:23,699 --> 01:40:24,933
THAT CONCLUDES OUR REPORTS ON

2345
01:40:24,933 --> 01:40:28,337
THE TASK FORCE ON AGING AND

2346
01:40:28,337 --> 01:40:30,706
WORKING GROUP ON PROGRAM.

2347
01:40:30,706 --> 01:40:34,042
LET'S SEE.

2348
01:40:34,042 --> 01:40:37,846
SO I THINK AT THIS TIME LET'S

2349
01:40:37,846 --> 01:40:39,614
TAKE A QUICK FIVE OR TEN-MINUTE

2350
01:40:39,614 --> 01:40:43,652
BREAK AND WE'RE GOING TO HAVE

2351
01:40:43,652 --> 01:40:47,723
OUR FIRST SPEAKER, AND I'LL HAVE

2352
01:40:47,723 --> 01:40:48,390
LYNDON JOHNSON INTRODUCE HER

2353
01:40:48,390 --> 01:40:50,225
WHEN WE ALL COME BACK FROM

2354
01:40:50,225 --> 01:40:51,893
BREAK.

2355
01:40:51,893 --> 01:40:56,932
LET'S TAKE A 10-MINUTE BREAK.

2356
01:40:56,932 --> 01:40:58,552
10:50, PLEASE REPORT BACK AT
10:50.
THANK YOU. 

2357
01:40:59,568 --> 01:41:00,102


2358
01:41:00,102 --> 01:41:08,977


2359
01:41:08,977 --> 01:41:19,020
 

2360
01:41:03,486 --> 01:41:04,921
>> WE COULD ALL SIT DOWN
WE'RE

2361
01:41:04,921 --> 01:41:07,357
GOING TO GET STARTED WITH OUR

2362
01:41:07,357 --> 01:41:10,727
FIRST SPEAKER.

2363
01:41:10,727 --> 01:41:12,896
 

2364
01:41:12,896 --> 01:41:13,363
THANK YOU.

2365
01:41:13,363 --> 01:41:16,132
LYNDON, DO YOU WANT TO INTRODUCE

2366
01:41:16,132 --> 01:41:16,599
OUR SPEAKER?

2367
01:41:16,599 --> 01:41:17,734
>> GOOD MORNING, EVERYONE.

2368
01:41:17,734 --> 01:41:25,075
IT'S MY PLEASURE TO INTRODUCE 

2369
01:41:25,075 --> 01:41:27,477
DR. TUHINA NEOGI, THE DGCG

2370
01:41:27,477 --> 01:41:29,579
SPEAKER TODAY, PROFESSOR OF

2371
01:41:29,579 --> 01:41:30,980
MEDICINE AND EPIDEMIOLOGY,

2372
01:41:30,980 --> 01:41:37,020
BOSTON UNIVERSITY SCHOOL OF

2373
01:41:37,020 --> 01:41:39,089
MEDICINE, PUBLIC HEALTH, ALAN S

2374
01:41:39,089 --> 01:41:43,793
COHEN PROFESSOR OF RHEUMATOLOGY,

2375
01:41:43,793 --> 01:41:46,096
CHIEF OF RHEUMATOLOGY, BOSTON

2376
01:41:46,096 --> 01:41:48,932
MEDICAL CENTER, RESEARCH FOCUSES

2377
01:41:48,932 --> 01:41:51,468
ON OSTEOPOROSIS AND GOUT,

2378
01:41:51,468 --> 01:41:52,869
PARTICULARLY ON PAIN MECHANISM.

2379
01:41:52,869 --> 01:41:58,675
HAS BEEN FUNDED BY THE WAY

2380
01:41:58,675 --> 01:42:04,581
THROUGH NIH SINCE ABOUT 2003,

2381
01:42:04,581 --> 01:42:06,983
CONTINUOUSLY SINCE THEN, ALSO

2382
01:42:06,983 --> 01:42:14,991
BEEN PAST CHAIR OF FDA ADVISORY

2383
01:42:14,991 --> 01:42:15,692
COMMITTEE, NUMEROUS BOARDS

2384
01:42:15,692 --> 01:42:16,759
INCLUDING OSTEOARTHRITIS

2385
01:42:16,759 --> 01:42:19,395
RESEARCH, SOCIETY OF

2386
01:42:19,395 --> 01:42:20,130
INTERNATIONAL ORGANIZATION, AND

2387
01:42:20,130 --> 01:42:20,930
AMERICAN COLLEGE OF

2388
01:42:20,930 --> 01:42:21,698
RHEUMATOLOGY.

2389
01:42:21,698 --> 01:42:22,999
SHE'S ALSO PART OF THE

2390
01:42:22,999 --> 01:42:25,835
INTERNATIONAL ASSOCIATION FOR

2391
01:42:25,835 --> 01:42:28,471
STUDY OF PAIN.

2392
01:42:28,471 --> 01:42:29,939
DEPUTY EDITOR FOR OSTEOARTHRITIS

2393
01:42:29,939 --> 01:42:34,911
JOURNAL, AND WORK HAS BEEN

2394
01:42:34,911 --> 01:42:38,414
RECOGNIZED IN 2014 AS HENRY

2395
01:42:38,414 --> 01:42:40,517
KUNKEL YOUNG INVESTIGATOR AWARD

2396
01:42:40,517 --> 01:42:47,190
FOR INDEPENDENT CONTRIBUTIONS TO

2397
01:42:47,190 --> 01:42:50,593
RHEUMATOLOGY RESEARCH.

2398
01:42:50,593 --> 01:42:57,233
SHE'S ALSO HONORARY DOCTORATE

2399
01:42:57,233 --> 01:43:00,103
FROM SWEDEN, AND ENGAGED IN NEW

2400
01:43:00,103 --> 01:43:02,505
CLASSIFICATION FOR RHEUMATIC

2401
01:43:02,505 --> 01:43:04,374
DISEASES, LED THE NATIONAL ACR

2402
01:43:04,374 --> 01:43:06,643
TREATMENT GUIDELINES FOR ADULT

2403
01:43:06,643 --> 01:43:08,578
AND OSTEOARTHRITIS.

2404
01:43:08,578 --> 01:43:12,015
IN ADDITION TO RESEARCH, HAS

2405
01:43:12,015 --> 01:43:15,718
MENTORED QUITE A FEW POSTDOC AND

2406
01:43:15,718 --> 01:43:18,588
JUNIOR FACULTY, OVER 40 OF

2407
01:43:18,588 --> 01:43:23,626
THOSE, 18 HAVE RECEIVED NIH K

2408
01:43:23,626 --> 01:43:23,860
AWARDS.

2409
01:43:23,860 --> 01:43:27,664
OF PARTICULAR INTEREST TO THE

2410
01:43:27,664 --> 01:43:29,966
TALK TODAY, HAS BEEN ON THE

2411
01:43:29,966 --> 01:43:32,268
EXECUTIVE COMMITTEE, STEERING

2412
01:43:32,268 --> 01:43:35,104
COMMITTEE FOR THE STUDY FUNDED

2413
01:43:35,104 --> 01:43:37,240
BY NIA OVER 20 YEARS, ON THE

2414
01:43:37,240 --> 01:43:38,942
EXECUTIVE COMMITTEE FOR MORE

2415
01:43:38,942 --> 01:43:39,609
THAN 10 YEARS.

2416
01:43:39,609 --> 01:43:43,313
SHE HAS WORKED ON A LOT OF LARGE

2417
01:43:43,313 --> 01:43:44,414
COHORT STUDIES INCLUDING

2418
01:43:44,414 --> 01:43:48,017
FRAMINGHAM HEART STUDY AND

2419
01:43:48,017 --> 01:43:49,886
JACKSON HEART STUDY.

2420
01:43:49,886 --> 01:43:57,327
WITHOUT FURTHER ADO I PRESENT

2421
01:43:57,327 --> 01:43:58,728
DR. NEOGI, TALKING ON

2422
01:43:58,728 --> 01:44:00,363
OSTEOARTHRITIS AND CHRONIC PAIN

2423
01:44:00,363 --> 01:44:05,301
IN OLDER ADULTS, INSIGHTS FROM

2424
01:44:05,301 --> 01:44:06,736
THE MOST AND FRAMINGHAM STUDIES.

2425
01:44:06,736 --> 01:44:08,605
>> I'M HONORED TO HAVE
BEEN

2426
01:44:08,605 --> 01:44:12,208
INVITED AS THE GUEST SPEAKER FOR

2427
01:44:12,208 --> 01:44:13,176
THE COUNCIL MEETING.

2428
01:44:13,176 --> 01:44:14,877
AND I'M HONORED TO BE ABLE TO

2429
01:44:14,877 --> 01:44:17,647
PRESENT SOME OF THE DATA THAT

2430
01:44:17,647 --> 01:44:19,515
WE'VE GATHERED AND ANALYZED OVER

2431
01:44:19,515 --> 01:44:22,085
THE YEARS WITH NIA'S GENEROUS

2432
01:44:22,085 --> 01:44:23,886
SUPPORT WITH OUR GRANTS.

2433
01:44:23,886 --> 01:44:25,188
I'M STANDING BETWEEN US AND

2434
01:44:25,188 --> 01:44:27,857
LUNCH AND DEPARTURE SO I'LL KEEP

2435
01:44:27,857 --> 01:44:28,625
ON TIME HERE.

2436
01:44:28,625 --> 01:44:31,361
FIRST, WHAT IS THE PURPOSE OF

2437
01:44:31,361 --> 01:44:31,995
PAIN?

2438
01:44:31,995 --> 01:44:35,531
ACUTE PAIN IS INTENDED TO 

2439
01:44:35,531 --> 01:44:36,699
PROTECT OURSELVES FROM HARM.

2440
01:44:36,699 --> 01:44:38,334
TOUCH A HOT STUFF, YOU PULL

2441
01:44:38,334 --> 01:44:42,605
BACK, GO FOR A JOG AND TWIST

2442
01:44:42,605 --> 01:44:44,607
YOUR ANKLE AND LIMP TO ALLOW

2443
01:44:44,607 --> 01:44:47,110
INTERTISSUE TO NOT HAVE ONGOING

2444
01:44:47,110 --> 01:44:48,745
INJURY AND TO ALLOW ITSELF TO

2445
01:44:48,745 --> 01:44:48,945
HEAL.

2446
01:44:48,945 --> 01:44:52,048
ONCE THE TISSUE IS HEALED THE

2447
01:44:52,048 --> 01:44:53,583
PAIN GOES AWAY.

2448
01:44:53,583 --> 01:44:55,885
IN MANY INSTANCES OF CHRONIC

2449
01:44:55,885 --> 01:44:57,987
PAIN, WHEN THE INJURY IS HEALED

2450
01:44:57,987 --> 01:44:59,522
AND THERE'S STILL ONGOING PAIN

2451
01:44:59,522 --> 01:45:01,057
EXPERIENCED, THAT IS NO LONGER

2452
01:45:01,057 --> 01:45:03,359
HAVING A PROTECTIVE FUNCTION.

2453
01:45:03,359 --> 01:45:03,960
THAT'S CONSIDERED MALADAPTIVE.

2454
01:45:03,960 --> 01:45:05,995
ON THE OTHER HAND, THERE ARE

2455
01:45:05,995 --> 01:45:09,465
MANY DISEASES IN WHICH THAT

2456
01:45:09,465 --> 01:45:13,970
CONTINUES AND A DISEASE LIKE

2457
01:45:13,970 --> 01:45:14,337
OSTEOARTHRITIS.

2458
01:45:14,337 --> 01:45:17,707
ONE CAN HAVE CHRONIC PAIN THAT'S

2459
01:45:17,707 --> 01:45:19,776
MAL ADAPTIVE OR BECAUSE THE

2460
01:45:19,776 --> 01:45:21,311
NOXIOUS STIMULUS IS ONGOING.

2461
01:45:21,311 --> 01:45:23,279
CHRONIC PAIN IS MORE PREVALENT

2462
01:45:23,279 --> 01:45:24,480
AND COSTLY THAN OTHER COMMON

2463
01:45:24,480 --> 01:45:25,348
DISEASES.

2464
01:45:25,348 --> 01:45:27,750
IN THE U.S. 100 MILLION ADULTS

2465
01:45:27,750 --> 01:45:30,053
HAVE CHRONIC PAIN, WORLD WILD

2466
01:45:30,053 --> 01:45:35,625
OTHER 1.5 BILLION, 20%.

2467
01:45:35,625 --> 01:45:38,027
THAT PREVALENCE IS HIGHER THAN

2468
01:45:38,027 --> 01:45:38,695
CARDIOVASCULAR DISEASE,

2469
01:45:38,695 --> 01:45:40,563
DIABETES, CANCER ALL TOGETHER.

2470
01:45:40,563 --> 01:45:43,933
THE VAST MAJORITY OF CHRONIC

2471
01:45:43,933 --> 01:45:46,035
PAIN ARE MUSCULOSKELETAL

2472
01:45:46,035 --> 01:45:46,669
CONDITIONS CONDITIONS INCLUDING

2473
01:45:46,669 --> 01:45:47,570
OSTEOARTHRITIS AND CHRONIC LOW

2474
01:45:47,570 --> 01:45:50,473
BACK PAIN, AND THESE ARE MORE

2475
01:45:50,473 --> 01:45:52,275
COSTLY TO THE U.S. HEALTH CARE

2476
01:45:52,275 --> 01:45:56,679
SYSTEM AND SOCIETY MORE BROADLY

2477
01:45:56,679 --> 01:45:59,615
THAN CANCER, CARDIOVASCULAR

2478
01:45:59,615 --> 01:46:00,717
DISEASE, DIABETES.

2479
01:46:00,717 --> 01:46:03,453
THE MAJORITY OF CHRONIC PAIN IS

2480
01:46:03,453 --> 01:46:04,354
OSTEOARTHRITIS AND LOW BACK PAIN

2481
01:46:04,354 --> 01:46:07,824
AND OVER TO THE RIGHT OF THE

2482
01:46:07,824 --> 01:46:11,094
FIGURE YOU SEE THAT DIABETIC

2483
01:46:11,094 --> 01:46:12,095
PERIPHERAL NEUROPATHY,

2484
01:46:12,095 --> 01:46:13,396
MIGRAINES, DAILY HEADACHES ARE

2485
01:46:13,396 --> 01:46:14,464
MUCH LOWER PREVALENCE, YET WHEN

2486
01:46:14,464 --> 01:46:21,738
I GO TO BRAIN CONFERENCES THE IN

2487
01:46:21,738 --> 01:46:26,142
 MAJORITY OF RESEARCH IS ON

2488
01:46:26,142 --> 01:46:27,009
THAT.

2489
01:46:27,009 --> 01:46:28,644
ALMOST 600-MILLION PEOPLE

2490
01:46:28,644 --> 01:46:30,713
WORLDWIDE REFLECT 10 TO 15% OF

2491
01:46:30,713 --> 01:46:32,148
ADULT POPULATIONS, THE KNEE IS

2492
01:46:32,148 --> 01:46:33,783
THE MOST COMMON SITE OF

2493
01:46:33,783 --> 01:46:36,085
SYMPTOMS, IN THE U.S. IN THE

2494
01:46:36,085 --> 01:46:38,054
PRIOR 30 DAYS APPROXIMATELY 30%

2495
01:46:38,054 --> 01:46:39,389
OF ADULTS WILL REPORT HAVING

2496
01:46:39,389 --> 01:46:40,690
EXPERIENCED KNEE PAIN.

2497
01:46:40,690 --> 01:46:41,991
LOOK AROUND YOUR COLLEAGUES,

2498
01:46:41,991 --> 01:46:43,559
ABOUT 30% OF YOU WILL HAVE HAD

2499
01:46:43,559 --> 01:46:47,063
KNEE PAIN IN THE PAST 30 DAYS.

2500
01:46:47,063 --> 01:46:48,798
INITIALLY IN KNEE OSTEOARTHRITIS

2501
01:46:48,798 --> 01:46:51,534
KNEE PAIN IS WEIGHT BEARING AND

2502
01:46:51,534 --> 01:46:54,170
ACTIVITY RELATED.

2503
01:46:54,170 --> 01:46:55,605
COULD BE JOGGING, WALKING,

2504
01:46:55,605 --> 01:46:56,806
TENNIS, SKIING, ET CETERA.

2505
01:46:56,806 --> 01:46:58,641
OVER TIME PAIN BECOMES MORE

2506
01:46:58,641 --> 01:47:02,345
PERSISTENT AND MORE SEVERE AND

2507
01:47:02,345 --> 01:47:03,346
CAN HAVE FLUCTUATIONS INCLUDING

2508
01:47:03,346 --> 01:47:05,081
FLARES THAT PEOPLE CAN'T FIGURE

2509
01:47:05,081 --> 01:47:08,418
OUT WHY THEIR KNEE ALL OF A 

2510
01:47:08,418 --> 01:47:14,290
SUDDEN GOT MUCH WORSE. 

2511
01:47:14,290 --> 01:47:16,492
JOINT PAIN IN THE U.S. IS THE

2512
01:47:16,492 --> 01:47:17,593
MOST COMMON REASON FOR VISITS,

2513
01:47:17,593 --> 01:47:19,929
THIS IS WHAT THEY ARE

2514
01:47:19,929 --> 01:47:27,403
PREDOMINANTLY SEEING. 

2515
01:47:27,403 --> 01:47:31,240
WORLDWIDE MUSCULOSKELETAL 

2516
01:47:31,240 --> 01:47:34,977
CONDITIONS ARE LEADING CAUSE OF

2517
01:47:34,977 --> 01:47:35,545
DISABILITY, MOST SHOCKINGLY

2518
01:47:35,545 --> 01:47:37,513
OSTEOARTHRITIS IS THE THIRD

2519
01:47:37,513 --> 01:47:38,080
LEADING HOSPITAL DISCHARGE

2520
01:47:38,080 --> 01:47:40,683
DIAGNOSIS IN THE U.S., THIRD

2521
01:47:40,683 --> 01:47:42,652
AFTER CHILD BIRTH RELATED

2522
01:47:42,652 --> 01:47:46,022
HOSPITALIZATIONS AND SEPSIS.

2523
01:47:46,022 --> 01:47:48,458
THIS IS MORE COMMON THAN ALL THE

2524
01:47:48,458 --> 01:47:49,192
CARDIOVASCULAR ADMISSIONS THAT

2525
01:47:49,192 --> 01:47:54,764
WE AS MEDICAL STUDENTS AND 

2526
01:47:54,764 --> 01:47:56,732
TRAINEES HAD TAKEN CARE OF

2527
01:47:56,732 --> 01:47:57,600
BECAUSE OF JOINT REPLACEMENT

2528
01:47:57,600 --> 01:47:59,702
SURGERY, ONE OF THE MOST COMMON

2529
01:47:59,702 --> 01:48:01,237
ORTHOPEDIC SURGERIES, WITH A

2530
01:48:01,237 --> 01:48:03,873
PAUCITY OF EFFECTIVE AND SAFE

2531
01:48:03,873 --> 01:48:04,507
THERAPEUTIC OPTIONS FOR

2532
01:48:04,507 --> 01:48:05,508
OSTEOARTHRITIS THAT WE HAVE

2533
01:48:05,508 --> 01:48:07,577
MILLIONS OF PEOPLE IN THIS

2534
01:48:07,577 --> 01:48:09,745
COUNTRY WITH JOINT REPLACEMENT

2535
01:48:09,745 --> 01:48:12,715
AS THE DEFINITIVE BUT LAST

2536
01:48:12,715 --> 01:48:13,916
RESORT MANAGEMENT OPS.

2537
01:48:13,916 --> 01:48:16,352
A HUGE PUBLIC HEALTH BURDEN.

2538
01:48:16,352 --> 01:48:18,988
I'M GOING TO FRAME THE

2539
01:48:18,988 --> 01:48:20,623
DISCUSSIONS ABOUT OSTEOARTHRITIS

2540
01:48:20,623 --> 01:48:26,662
AND PAIN USING TWO NIA-FUNDED

2541
01:48:26,662 --> 01:48:26,896
STUDIES.

2542
01:48:26,896 --> 01:48:27,997
THE MULTI-CENTER OSTEOARTHRITIS

2543
01:48:27,997 --> 01:48:29,165
STUDY COMPRISES 3,000 OLDER

2544
01:48:29,165 --> 01:48:33,102
ADULTS WITH OR AT RISK OF KNEE

2545
01:48:33,102 --> 01:48:35,438
OSTEOARTHRITIS WHEN ENROLLED, 20

2546
01:48:35,438 --> 01:48:39,909
YEARS AGO NOW, 2003-2005.

2547
01:48:39,909 --> 01:48:41,644
AND MOST RECENTLY FOURTH CYCLE

2548
01:48:41,644 --> 01:48:43,079
FUNDED BY A U19, WE'RE ABOUT TO

2549
01:48:43,079 --> 01:48:46,148
START IN THE FIELD ANY DAY NOW

2550
01:48:46,148 --> 01:48:48,551
FOR THE 20th YEAR, FRAMINGHAM

2551
01:48:48,551 --> 01:48:49,952
STUDY YOU'RE FAMILIAR WITH, OVER

2552
01:48:49,952 --> 01:48:54,223
75 YEARS IN THE FIELD,

2553
01:48:54,223 --> 01:48:55,124
GROUNDBREAKING COHORT STUDY FOR

2554
01:48:55,124 --> 01:48:58,728
CARDIOVASCULAR DISEASE BUT ALSO

2555
01:48:58,728 --> 01:48:59,395
BRAIN HEALTH.

2556
01:48:59,395 --> 01:49:02,098
AND MANY OTHER CONDITIONS.

2557
01:49:02,098 --> 01:49:11,607
THE ORIGINAL  COHORT, OFFSPRING,

2558
01:49:11,607 --> 01:49:12,909
GENERATION 2 AND 3.

2559
01:49:12,909 --> 01:49:15,778
BECAUSE OF LIMITED TIME I'M NOT

2560
01:49:15,778 --> 01:49:18,281
GOING TO SHARE THE JACKSON HEART

2561
01:49:18,281 --> 01:49:22,018
STUDY BUT WE ARE IN MIDDLE SO I

2562
01:49:22,018 --> 01:49:24,086
DON'T HAVE DATA TO SHOW YET.

2563
01:49:24,086 --> 01:49:26,155
FIRST I'M GOING TO FOCUS ON

2564
01:49:26,155 --> 01:49:27,657
OSTEOARTHRITIS.

2565
01:49:27,657 --> 01:49:30,326
ONE OF THE MAJOR CONUNDRUMS IS

2566
01:49:30,326 --> 01:49:32,395
THIS SO-CALLED STRUCTURE SYMPTOM

2567
01:49:32,395 --> 01:49:33,930
DISCORDANCE, THAT IS WHERE SOME

2568
01:49:33,930 --> 01:49:36,032
KNEES HAVE PAIN BUT VERY LITTLE

2569
01:49:36,032 --> 01:49:37,033
RADIOGRAPHIC CHANGES.

2570
01:49:37,033 --> 01:49:40,503
OTHER KNEES CAN LOOK TERRIBLE ON

2571
01:49:40,503 --> 01:49:42,939
X-RAY, MINIMAL OR NO PAIN.

2572
01:49:42,939 --> 01:49:45,341
OVERLAP BETWEEN HAVING KNEE PAIN

2573
01:49:45,341 --> 01:49:48,311
AND RADIOGRAPHIC FEATURES IS

2574
01:49:48,311 --> 01:49:48,778
INCOMPLETE.

2575
01:49:48,778 --> 01:49:50,146
THIS LED TO DISCUSSION ABOUT,

2576
01:49:50,146 --> 01:49:52,081
WELL, MAYBE WHAT'S GOING ON IN

2577
01:49:52,081 --> 01:49:55,484
THE KNEE, PATHOLOGY ISN'T REALLY

2578
01:49:55,484 --> 01:49:57,153
CONTRIBUTING TO PAIN.

2579
01:49:57,153 --> 01:50:00,122
BUT AS YOU LIKELY APPRECIATE,

2580
01:50:00,122 --> 01:50:01,023
EVERYONE EXPERIENCES PAIN

2581
01:50:01,023 --> 01:50:01,324
DIFFERENTLY.

2582
01:50:01,324 --> 01:50:03,092
IF I PUNCH ONE PERSON WITH THE

2583
01:50:03,092 --> 01:50:05,294
SAME FORCE AS ANOTHER PERSON,

2584
01:50:05,294 --> 01:50:07,363
THOSE TWO INDIVIDUALS WILL

2585
01:50:07,363 --> 01:50:08,998
EXPERIENCE IT DIFFERENTLY.

2586
01:50:08,998 --> 01:50:10,866
WHEN I WAS A POSTDOC AND WORKING

2587
01:50:10,866 --> 01:50:13,369
ON MY Ph.D. I TOOK AN

2588
01:50:13,369 --> 01:50:14,704
EPIDEMIOLOGIST PERSPECTIVE, HOW

2589
01:50:14,704 --> 01:50:18,574
DO WE GET RID OF BETWEEN-PERSON

2590
01:50:18,574 --> 01:50:20,476
FACTORS, CONFOUNDERS THAT CLOUD

2591
01:50:20,476 --> 01:50:22,278
THIS UNDERSTANDING OF HOW DOES

2592
01:50:22,278 --> 01:50:24,213
JOINT PATHOLOGY CONTRIBUTE TO

2593
01:50:24,213 --> 01:50:26,616
PAIN, AND THE APPROACH I TOOK

2594
01:50:26,616 --> 01:50:30,252
WAS LOOKING AT PEOPLE WITH PAIN

2595
01:50:30,252 --> 01:50:32,088
IN ONE KNEE, NOT THE OTHER.

2596
01:50:32,088 --> 01:50:35,958
THEN ALL OF THOSE BETWEEN-PERSON

2597
01:50:35,958 --> 01:50:39,195
DIFFERENCES, SEX, GENETICS, HOW 

2598
01:50:39,195 --> 01:50:42,598
WELL YOU SLEPT, MOOD,

2599
01:50:42,598 --> 01:50:43,265
EXPECTATIONS, ALL INHERENTLY

2600
01:50:43,265 --> 01:50:44,567
CONTROLLED FOR IN THAT

2601
01:50:44,567 --> 01:50:45,101
INDIVIDUAL.

2602
01:50:45,101 --> 01:50:46,636
ONE KNEE HAS PAIN, OTHER KNEE

2603
01:50:46,636 --> 01:50:47,570
DOES NOT, THERE MUST BE

2604
01:50:47,570 --> 01:50:49,171
SOMETHING GOING ON IN THE KNEE.

2605
01:50:49,171 --> 01:50:51,774
IF YOU DO THAT ANALYSIS HERE ON

2606
01:50:51,774 --> 01:50:54,944
THE X-AXIS IS THE RADIOGRAPHIC

2607
01:50:54,944 --> 01:50:59,215
SEVERITY OF O.A., WITH GRADE 2

2608
01:50:59,215 --> 01:51:00,750
BEING DEFINITION OF DEFINITIVE

2609
01:51:00,750 --> 01:51:03,152
RADIOGRAPHIC O.A.

2610
01:51:03,152 --> 01:51:06,756
ON Y-AXIS ODDS RATIOS FOR HAVING

2611
01:51:06,756 --> 01:51:11,060
KNEE PAIN, I DID THIS IN BOTH

2612
01:51:11,060 --> 01:51:12,695
THE MOST STUDY AND FRAMINGHAM.

2613
01:51:12,695 --> 01:51:16,332
YOU CAN SEE DOSE-RESPONSE

2614
01:51:16,332 --> 01:51:18,634
RELATIONSHIP GOING UP TO ODD

2615
01:51:18,634 --> 01:51:20,469
RATIOS OF 100, VERY STRONG

2616
01:51:20,469 --> 01:51:21,671
RELATIONSHIP OF PATHOLOGY TO

2617
01:51:21,671 --> 01:51:21,904
PAIN.

2618
01:51:21,904 --> 01:51:25,975
WHY DON'T WE SEE THIS IN BROADER

2619
01:51:25,975 --> 01:51:26,575
GENERAL EPIDEMIOLOGIC STUDIES

2620
01:51:26,575 --> 01:51:27,710
THAT THAT'S BECAUSE THERE ARE

2621
01:51:27,710 --> 01:51:28,711
ALL THOSE OTHER FACTORS THAT

2622
01:51:28,711 --> 01:51:31,113
CONTRIBUTE TO THE PAIN

2623
01:51:31,113 --> 01:51:31,981
EXPERIENCE THAT WE RARELY

2624
01:51:31,981 --> 01:51:33,949
MEASURE AND CONTROL FOR IN OUR

2625
01:51:33,949 --> 01:51:34,417
STUDIES.

2626
01:51:34,417 --> 01:51:35,818
FOR ME AS A CLINICIAN ONE OF THE

2627
01:51:35,818 --> 01:51:40,089
MOST IMPORTANT THINGS I DO FOR

2628
01:51:40,089 --> 01:51:43,159
EVERYONE IS UNDERSTAND SLEEP,

2629
01:51:43,159 --> 01:51:45,795
MOOD, COPING SKILLS, WHETHER

2630
01:51:45,795 --> 01:51:47,196
THEY HAVE HAVING

2631
01:51:47,196 --> 01:51:47,563
CATASTROPHIZING.

2632
01:51:47,563 --> 01:51:49,265
NO MATTER WHAT I DO IF THOSE

2633
01:51:49,265 --> 01:51:50,800
THINGS ARE NOT ADDRESSED WE

2634
01:51:50,800 --> 01:51:52,201
WON'T GET OPTIMAL PAIN

2635
01:51:52,201 --> 01:51:52,668
MANAGEMENT.

2636
01:51:52,668 --> 01:51:55,171
I'M GOING TO SHOW WITH THE NIA

2637
01:51:55,171 --> 01:51:58,340
FUNDING WHAT WE'VE BEEN ABLE TO

2638
01:51:58,340 --> 01:52:00,309
DO TO FURTHER DISCERN

2639
01:52:00,309 --> 01:52:04,180
JOINT@OLOGY  -- PATHOLOGY

2640
01:52:04,180 --> 01:52:09,285
CONTRIBUTORS NOT UNDERSTOOD TO

2641
01:52:09,285 --> 01:52:15,725
DATE, CCPD IS CALCIUM CRYSTALS,

2642
01:52:15,725 --> 01:52:16,826
CAUSING PSEUDOGOUT, NO LONGER

2643
01:52:16,826 --> 01:52:18,260
THE TERM USED.

2644
01:52:18,260 --> 01:52:22,098
ON X-RAY CAN BE SEEN AS

2645
01:52:22,098 --> 01:52:24,400
CHONDROCALCINOSIS, THOUGHT TO BE

2646
01:52:24,400 --> 01:52:25,034
ASYMPTOMATIC.

2647
01:52:25,034 --> 01:52:27,002
BECAUSE BOTH CPPD AND

2648
01:52:27,002 --> 01:52:28,337
OSTEOARTHRITIS INCREASE IN

2649
01:52:28,337 --> 01:52:29,538
PREVALENCE WITH AGE,

2650
01:52:29,538 --> 01:52:30,740
CO-OCCURRENCE WAS THOUGHT TO BE

2651
01:52:30,740 --> 01:52:33,142
TOO COMMON THINGS THAT OCCUR

2652
01:52:33,142 --> 01:52:36,545
WITH AGING AND THESE CALCIUM

2653
01:52:36,545 --> 01:52:43,886
CHRIS  CRYSTALS WITH NOT DOING

2654
01:52:43,886 --> 01:52:44,653
ANYTHING.

2655
01:52:44,653 --> 01:52:45,521
THESE CAN CAUSE PSEUDOGOUT, WHY

2656
01:52:45,521 --> 01:52:47,490
DO WE THINK THEY DON'T HAVE

2657
01:52:47,490 --> 01:52:48,491
PATHOLOGIC EFFECT?

2658
01:52:48,491 --> 01:52:51,527
WE WANTED TO STUDY WHETHER THIS

2659
01:52:51,527 --> 01:52:54,396
COULD ACTUALLY HAVE A PATHOLOGIC

2660
01:52:54,396 --> 01:52:55,464
IMPLICATION TO OSTEOARTHRITIS.

2661
01:52:55,464 --> 01:52:57,767
IN THE LAST CYCLE OF MOST,

2662
01:52:57,767 --> 01:53:01,003
FUNDED THROUGH A SERIES OF U01

2663
01:53:01,003 --> 01:53:06,642
MECHANIC  MECHANISM GRANTS WE

2664
01:53:06,642 --> 01:53:10,913
WERE THE FIRST TO OBTAIN KNEE

2665
01:53:10,913 --> 01:53:13,616
CTs, HOPEFULLY IT'S

2666
01:53:13,616 --> 01:53:16,385
PROJECTING, IT'S HARD TO SEE

2667
01:53:16,385 --> 01:53:17,787
WHETHER THERE'S ANY

2668
01:53:17,787 --> 01:53:19,021
CALCIUMIZATION IN THE KNEE BUT

2669
01:53:19,021 --> 01:53:21,390
ON CT YOU CAN CLEARLY SEE AREAS

2670
01:53:21,390 --> 01:53:22,591
OF MINERALIZATION.

2671
01:53:22,591 --> 01:53:24,693
WITH THE THREE DIMENSIONAL

2672
01:53:24,693 --> 01:53:26,562
NATURE OF THE IMAGING MUCH MORE

2673
01:53:26,562 --> 01:53:28,531
ABLE TO SEE THIS.

2674
01:53:28,531 --> 01:53:32,468
AND WHAT WE FOUND WITH THE CT

2675
01:53:32,468 --> 01:53:34,470
THE PREVALENCE OF MINERALIZATION

2676
01:53:34,470 --> 01:53:37,406
IN COHORT WAS OVER 13% YOU ABOUT

2677
01:53:37,406 --> 01:53:41,010
ON PAIRED RADIOGRAPHS UNDER 7%,

2678
01:53:41,010 --> 01:53:42,878
DOUBLE THE PREVALENCE.

2679
01:53:42,878 --> 01:53:44,079
SOMETHING MORE SENSITIVE AND

2680
01:53:44,079 --> 01:53:48,384
IDENTIFYING MORE, YOU HAVE LESS

2681
01:53:48,384 --> 01:53:48,784
MISCLASSIFICATION.

2682
01:53:48,784 --> 01:53:51,453
NOW WE SHOWED FOR FIRST TIME

2683
01:53:51,453 --> 01:53:52,221
THAT THIS CALCIUM DEPOSITION

2684
01:53:52,221 --> 01:53:54,390
INCREASES RISK FOR KNEE PAIN

2685
01:53:54,390 --> 01:53:55,691
DEVELOPMENT AND WORSENING OVER

2686
01:53:55,691 --> 01:53:56,492
TWO YEARS.

2687
01:53:56,492 --> 01:53:59,328
AND ALSO THAT IT INCREASES RISK

2688
01:53:59,328 --> 01:54:05,901
OF CARTILAGE DAMAGE IN THE SAME

2689
01:54:05,901 --> 01:54:07,636
LOCATION OVER TWO YEARS.

2690
01:54:07,636 --> 01:54:08,938
THIS MINERALIZATION THOUGHT TO

2691
01:54:08,938 --> 01:54:10,706
BE JUST AN INNOCENT BYSTANDER IS

2692
01:54:10,706 --> 01:54:12,575
NOT INNOCENT.

2693
01:54:12,575 --> 01:54:14,109
IT'S CAUSING INCREASE IN PAIN

2694
01:54:14,109 --> 01:54:16,545
AND INCREASE IN CARTILAGE DAMAGE

2695
01:54:16,545 --> 01:54:16,979
AND OSTEOARTHRITIS.

2696
01:54:16,979 --> 01:54:19,348
SO WHY IS THIS IMPORTANT?

2697
01:54:19,348 --> 01:54:20,983
THIS HAS TREMENDOUS TREATMENT

2698
01:54:20,983 --> 01:54:22,084
IMPLICATIONS FOR KNEE

2699
01:54:22,084 --> 01:54:22,451
OSTEOARTHRITIS.

2700
01:54:22,451 --> 01:54:26,355
WE HAVE A PAUCITY OF EFFECTIVE

2701
01:54:26,355 --> 01:54:27,890
TREATMENT OPTIONS FOR KNEE

2702
01:54:27,890 --> 01:54:28,457
OSTEOARTHRITIS.

2703
01:54:28,457 --> 01:54:39,001
IMPLICATION CAN BE GLEANED FROM

2704
01:54:46,876 --> 01:54:50,079
TWO CARDIOVASCULAR TRIALS,

2705
01:54:50,079 --> 01:54:52,081
CANTOS AND LODOCO2.

2706
01:54:52,081 --> 01:54:57,553
THESE TWO LARGE TRIALS, 10,000

2707
01:54:57,553 --> 01:55:01,590
FOR CANSOT, 5500 FOR LODOCO2,

2708
01:55:01,590 --> 01:55:08,797
FOUND IN A POST HOC ANALYSIS 

2709
01:55:08,797 --> 01:55:10,900
PARTICIPANTS ON INTERVENTION HAD

2710
01:55:10,900 --> 01:55:17,239
40% LOWER CHANCE OF JOINT

2711
01:55:17,239 --> 01:55:17,673
REPLACEMENT.

2712
01:55:17,673 --> 01:55:21,710
90% OF KNEE REPLACEMENTS ARE FOR

2713
01:55:21,710 --> 01:55:22,211
KNEE OSTEOARTHRITIS.

2714
01:55:22,211 --> 01:55:25,547
THEY MUST BE PEOPLE WHO HAVE

2715
01:55:25,547 --> 01:55:27,983
OSTEOARTHRITIS, THEY MAYBE HAVE

2716
01:55:27,983 --> 01:55:34,223
OA CCPD PHENOTYPE BECAUSE

2717
01:55:34,223 --> 01:55:35,324
ANTI-IL-1 THERAPY AND COLCHICINE

2718
01:55:35,324 --> 01:55:41,897
IS WHAT WE USED TO TREAT.

2719
01:55:41,897 --> 01:55:43,966
THEY HAVE BEEN TESTED, TRIALS

2720
01:55:43,966 --> 01:55:46,068
HAVE BEEN SMALL AND SHORT

2721
01:55:46,068 --> 01:55:46,902
DURATION.

2722
01:55:46,902 --> 01:55:50,205
AND IT TOOK HUGE 10,000 AND 5500

2723
01:55:50,205 --> 01:55:51,740
PARTICIPANT TRIALS OVER LONGER

2724
01:55:51,740 --> 01:55:53,175
PERIODS OF TIME FOUR AND FIVE

2725
01:55:53,175 --> 01:55:54,910
YEARS TO FIND A SIGNAL.

2726
01:55:54,910 --> 01:55:57,079
WE IN OSTEOARTHRITIS MAY BE

2727
01:55:57,079 --> 01:55:57,746
MISSING PROMISING TREATMENTS

2728
01:55:57,746 --> 01:56:00,582
BECAUSE OUR TRIALS HAVE BEEN TOO

2729
01:56:00,582 --> 01:56:02,351
SMALL, TOO SHORT, TOO

2730
01:56:02,351 --> 01:56:03,118
HETEROGENEOUS.

2731
01:56:03,118 --> 01:56:07,489
NOW I'M GOING TO SHIFT GEARS AND

2732
01:56:07,489 --> 01:56:08,090
FOCUS ON NEUROBIOLOGICAL

2733
01:56:08,090 --> 01:56:09,558
MECHANISMS OF PAIN.

2734
01:56:09,558 --> 01:56:11,327
FOR THOSE CLINICIANS THAT HAVE

2735
01:56:11,327 --> 01:56:12,962
SEEN PEOPLE WITH OSTEOARTHRITIS

2736
01:56:12,962 --> 01:56:14,163
YOU WILL HAVE RECOGNIZED THAT

2737
01:56:14,163 --> 01:56:15,698
THERE DOES SEEM TO BE SOMETHING

2738
01:56:15,698 --> 01:56:17,433
GOING ON WHERE INITIALLY IN

2739
01:56:17,433 --> 01:56:19,134
EARLY STAGES OF DISEASE PAIN MAY

2740
01:56:19,134 --> 01:56:20,803
BE MORE LOCALIZED FOR EXAMPLE TO

2741
01:56:20,803 --> 01:56:23,339
THE MEDIAL ASPECT OF THE KNEE

2742
01:56:23,339 --> 01:56:27,176
BUT LATER ON DISEASE PROGRESSES,

2743
01:56:27,176 --> 01:56:29,812
PAIN CAN BECOME MORE DIFFUSE,

2744
01:56:29,812 --> 01:56:34,216
SPATIAL SPREADING OF THE

2745
01:56:34,216 --> 01:56:34,483
SYMPTOMS.

2746
01:56:34,483 --> 01:56:38,687
AND IN THE LAST TEN YEARS OR SO

2747
01:56:38,687 --> 01:56:39,688
GREATER APPRECIATION FOR PAIN

2748
01:56:39,688 --> 01:56:42,324
MECHANISMS THAT CONTRIBUTE TO OA

2749
01:56:42,324 --> 01:56:43,726
PAIN EXPERIENCE HAVE COME TO

2750
01:56:43,726 --> 01:56:44,059
LIGHT.

2751
01:56:44,059 --> 01:56:47,096
WE KNOW THAT PAIN IS NOT SIMPLY

2752
01:56:47,096 --> 01:56:48,964
A SIMPLE STRAIGHT TRANSMISSION

2753
01:56:48,964 --> 01:56:51,166
FROM A NOXIOUS STIMULUS STRAIGHT

2754
01:56:51,166 --> 01:56:52,735
TO THE BRAIN.

2755
01:56:52,735 --> 01:56:54,436
WE NOW UNDERSTAND THERE CAN BE

2756
01:56:54,436 --> 01:56:56,872
ALTERATIONS IN THE WAY THESE

2757
01:56:56,872 --> 01:56:57,773
NOCICEPTORS FUNCTION.

2758
01:56:57,773 --> 01:56:59,174
IT'S NOT A NERVE LESION.

2759
01:56:59,174 --> 01:57:00,175
IT'S NOT A NEUROPATHY.

2760
01:57:00,175 --> 01:57:03,445
BUT JUST THE WAY IN WHICH THE

2761
01:57:03,445 --> 01:57:04,646
SIGNALS ARE GOING FROM THE

2762
01:57:04,646 --> 01:57:06,515
PERIPHERY TO THE SPINAL CORD TO

2763
01:57:06,515 --> 01:57:07,850
THE BRAIN.

2764
01:57:07,850 --> 01:57:11,553
IF YOU HAVE NOXIOUS STIMULI,

2765
01:57:11,553 --> 01:57:12,955
THOSE NOCICEPTORS WILL TRANSMIT

2766
01:57:12,955 --> 01:57:13,389
SIGNALS.

2767
01:57:13,389 --> 01:57:17,026
IN THE SETTING OF CENTRAL

2768
01:57:17,026 --> 01:57:19,762
SENSITIZATION NOCICEPTORS MAY

2769
01:57:19,762 --> 01:57:21,397
FIRE AT SUBTHRESHOLD INPUTS, AND

2770
01:57:21,397 --> 01:57:26,902
MAY HAVE MORE ACTION POTENTIAL

2771
01:57:26,902 --> 01:57:37,379
LEADING TO HYPERALESIA, MORE

2772
01:57:37,980 --> 01:57:38,113
PAIN.

2773
01:57:38,113 --> 01:57:38,680
ALLODYNIA, PAIN WHERE THERE

2774
01:57:38,680 --> 01:57:40,215
SHOULDN'T BE PAIN.

2775
01:57:40,215 --> 01:57:42,851
ASCENDING FACILITATION AS WELL

2776
01:57:42,851 --> 01:57:45,621
AS DESCENDING PAIN MODULATION

2777
01:57:45,621 --> 01:57:46,355
ABNORMALITIES THAT CAN

2778
01:57:46,355 --> 01:57:47,689
CONTRIBUTE TO OVERALL PAIN

2779
01:57:47,689 --> 01:57:48,757
EXPERIENCE.

2780
01:57:48,757 --> 01:57:51,393
IN ANIMAL MODELS IT'S EASIER TO

2781
01:57:51,393 --> 01:57:52,361
STUDY THIS WITH

2782
01:57:52,361 --> 01:57:53,062
ELECTROPHYSIOLOGY WE CAN'T

2783
01:57:53,062 --> 01:57:54,563
REALLY INTERROGATE THE SPINAL

2784
01:57:54,563 --> 01:57:58,200
CORD IN HUMANS SO WE USE

2785
01:57:58,200 --> 01:57:59,301
INDIRECT ASSESSMENT INCLUDING

2786
01:57:59,301 --> 01:58:02,137
QUANTITATIVE SENSORY TESTING.

2787
01:58:02,137 --> 01:58:04,873
FORGIVE MY VERY CRUDE CARTOON OF

2788
01:58:04,873 --> 01:58:07,142
THE PERIPHERAL NOCICEPTOR GOING

2789
01:58:07,142 --> 01:58:11,780
TO THE SPINAL CORD, TO THE

2790
01:58:11,780 --> 01:58:12,748
BRAIN, DESCENDING MODULATORY

2791
01:58:12,748 --> 01:58:13,282
PATHWAY.

2792
01:58:13,282 --> 01:58:15,717
TO EVALUATE THESE VARIOUS

2793
01:58:15,717 --> 01:58:22,524
PATHWAYS WE USE A VARIETY OF

2794
01:58:22,524 --> 01:58:23,092
INSTRUMENTS.

2795
01:58:23,092 --> 01:58:27,029
TO ASSESS PRINCIPLE NOCICEPTORS,

2796
01:58:27,029 --> 01:58:32,501
A HAND HELD, THE PRESSURE FIRST

2797
01:58:32,501 --> 01:58:36,872
CHANGES AT SLIGHT  PAIN.

2798
01:58:36,872 --> 01:58:39,741
LOWER THE THRESHOLD, MORE PAIN

2799
01:58:39,741 --> 01:58:41,477
SENSITIZATION, THIS CAN BE

2800
01:58:41,477 --> 01:58:43,245
INFERRED TO MEASURE CENTRAL

2801
01:58:43,245 --> 01:58:45,080
SENSITIZATION IF ASSESSED AT

2802
01:58:45,080 --> 01:58:46,381
NON-DISEASED SITE.

2803
01:58:46,381 --> 01:58:49,685
AND THEN TEMPORAL SUMMATION IS

2804
01:58:49,685 --> 01:58:52,187
REFLECTIVE OF ANIMAL PHENOMENON

2805
01:58:52,187 --> 01:58:54,389
OF WINDUP.

2806
01:58:54,389 --> 01:58:56,458
BY APPLYING PUNCTATE PROBE AT

2807
01:58:56,458 --> 01:58:58,994
REGULAR INTERVAL IF THERE'S NO

2808
01:58:58,994 --> 01:59:01,530
SENSITIZATION YOU EXPECT ACTION

2809
01:59:01,530 --> 01:59:03,699
POTENTIAL TO GENERATE THE SAME

2810
01:59:03,699 --> 01:59:05,701
LEVEL, YOU WOULD GET SAME LEVEL

2811
01:59:05,701 --> 01:59:07,236
OF PAIN.

2812
01:59:07,236 --> 01:59:09,972
IF SOMEONE HAS CENTRAL

2813
01:59:09,972 --> 01:59:11,173
SENSEIZATION WITH ASCENDING

2814
01:59:11,173 --> 01:59:12,141
STIMULATION STIMULI BUILD UP,

2815
01:59:12,141 --> 01:59:14,143
INCREASE IN PAIN RATING AFTER

2816
01:59:14,143 --> 01:59:16,979
THE TRAIN OF STIMULI.

2817
01:59:16,979 --> 01:59:18,947
FINALLY TO INTERROGATE

2818
01:59:18,947 --> 01:59:22,985
DESCENDING MODULATORY PATHWAY,

2819
01:59:22,985 --> 01:59:24,987
WE USE PARADIGM, A PROTOCOL,

2820
01:59:24,987 --> 01:59:27,189
CONDITIONED PAIN MODULATION.

2821
01:59:27,189 --> 01:59:31,126
HERE WE ASSESS PRESSURE PAIN

2822
01:59:31,126 --> 01:59:32,895
THRESHOLD, APPLY SECOND

2823
01:59:32,895 --> 01:59:33,529
CONDITIONING PAINFUL

2824
01:59:33,529 --> 01:59:35,964
CONDITIONING STIMULUS, AND IF

2825
01:59:35,964 --> 01:59:41,303
THAT ACTIVATES THE THEORY THAT

2826
01:59:41,303 --> 01:59:41,770
ACTIVATES DEDESCENDING

2827
01:59:41,770 --> 01:59:42,838
MODULATORY PATHWAY THE SECOND

2828
01:59:42,838 --> 01:59:45,574
TIME, THE PRESSURE PAIN

2829
01:59:45,574 --> 01:59:47,109
THRESHOLD SHOULD INCREASE, KIND

2830
01:59:47,109 --> 01:59:48,744
OF THE PAIN INHIBITS PAIN

2831
01:59:48,744 --> 01:59:49,278
PARADIGM.

2832
01:59:49,278 --> 01:59:50,712
THIS SLIDE IS GOING TO SUMMARIZE

2833
01:59:50,712 --> 01:59:53,448
ABOUT TEN YEARS WORTH OF STUDIES

2834
01:59:53,448 --> 01:59:54,650
WE'VE DONE.

2835
01:59:54,650 --> 01:59:55,884
FIRST FOCUSING ON ASCENDING

2836
01:59:55,884 --> 01:59:58,053
FACILITATION USING PRESSURE PAIN

2837
01:59:58,053 --> 01:59:59,788
THRESHOLD AND TEMPORAL SUMMATION

2838
01:59:59,788 --> 02:00:03,091
WE FOUND THESE MEASURES WERE

2839
02:00:03,091 --> 02:00:05,260
ASSOCIATED WITH PAIN SEVERITY,

2840
02:00:05,260 --> 02:00:07,563
ADJUSTING FOR POTENTIAL CON

2841
02:00:07,563 --> 02:00:09,298
FOUNDERS, BUT CONTRARY TO

2842
02:00:09,298 --> 02:00:11,033
HYPOTHESIS, THESE WERE NOT

2843
02:00:11,033 --> 02:00:12,467
ASSOCIATED WITH DEGREE OF

2844
02:00:12,467 --> 02:00:14,770
RADIOGRAPHIC SEVERITY.

2845
02:00:14,770 --> 02:00:15,437
WE HAD HYPOTHESIZED THE

2846
02:00:15,437 --> 02:00:16,972
PATHOLOGY, THE MORE SEVERE THE

2847
02:00:16,972 --> 02:00:19,841
PATHOLOGY, THE MORE LIKELY ONE

2848
02:00:19,841 --> 02:00:21,343
WOULD HAVE CENTRAL

2849
02:00:21,343 --> 02:00:22,110
SENSITIZATION, PERIPHERAL

2850
02:00:22,110 --> 02:00:22,444
SENSITIZATION.

2851
02:00:22,444 --> 02:00:24,980
WE DID NOT FIND THAT.

2852
02:00:24,980 --> 02:00:28,116
IN ADDITION WE HAD HYPOTHESIZED

2853
02:00:28,116 --> 02:00:33,055
LONGER ONE HAS DISEASE MORE

2854
02:00:33,055 --> 02:00:33,589
LIKELIHOOD OF DEVELOPING

2855
02:00:33,589 --> 02:00:35,791
SENSITIZATION, WE DID NOT FIND

2856
02:00:35,791 --> 02:00:36,024
THAT.

2857
02:00:36,024 --> 02:00:39,595
WE DELVED IN MORE.

2858
02:00:39,595 --> 02:00:41,697
RADIOGRAPHS ARE INSENSITIVE.

2859
02:00:41,697 --> 02:00:45,434
WHEN USING MRI DATA IN MOST, WE

2860
02:00:45,434 --> 02:00:47,402
HYPOTHESIZED THAT INFLAMMATORY

2861
02:00:47,402 --> 02:00:48,804
LESIONS AND MECHANICAL LESIONS

2862
02:00:48,804 --> 02:00:51,006
WHICH IN ANIMAL MODELS CAN LEAD

2863
02:00:51,006 --> 02:00:53,075
TO SENSITIZATION WOULD BE MOST

2864
02:00:53,075 --> 02:00:54,509
RELEVANT AND FOUND THAT

2865
02:00:54,509 --> 02:00:56,678
SYNOVITIS AND EFFUSIONS WERE

2866
02:00:56,678 --> 02:00:58,447
ASSOCIATED WITH SENSITIZATION

2867
02:00:58,447 --> 02:01:00,616
AND WORSENING SENSITIZATION BUT

2868
02:01:00,616 --> 02:01:02,484
BONE MARROW LESION WHICH

2869
02:01:02,484 --> 02:01:05,988
MECHANICALLY DRIVEN WERE NOT

2870
02:01:05,988 --> 02:01:06,989
ASSOCIATED WITH SENSITIZATION.

2871
02:01:06,989 --> 02:01:07,689
THEY CONTRIBUTE TO PAIN, THE

2872
02:01:07,689 --> 02:01:14,296
MECHANIC MILES  MECHANIC 

2873
02:01:14,296 --> 02:01:17,699
MECHANISM IS NOT THROUGH SEVEN

2874
02:01:17,699 --> 02:01:18,033
ADVERTISATION.

2875
02:01:18,033 --> 02:01:19,201
FINDINGS THAT WERE CONTRARY THEY

2876
02:01:19,201 --> 02:01:21,203
ARE NOT CONTRIBUTING TO

2877
02:01:21,203 --> 02:01:22,404
INCREASED RISK OF SENSITIZATION

2878
02:01:22,404 --> 02:01:23,238
RAISED THIS QUESTION WHETHER

2879
02:01:23,238 --> 02:01:25,340
THIS IS A STATE THAT'S INDUCED

2880
02:01:25,340 --> 02:01:27,743
OR A TRAIT INHERENT TO AN

2881
02:01:27,743 --> 02:01:28,043
INDIVIDUAL.

2882
02:01:28,043 --> 02:01:32,347
SO ONE OF MY MENTEES WHO IS NOW

2883
02:01:32,347 --> 02:01:34,316
ASSOCIATE PROFESSOR IN CANADA,

2884
02:01:34,316 --> 02:01:35,651
McMASTER UNIVERSITY, SHE AND I

2885
02:01:35,651 --> 02:01:39,688
WANTED TO PULL THIS BACK AND

2886
02:01:39,688 --> 02:01:43,759
LOOK AT PAIN  SUSCEPTIBILITY

2887
02:01:43,759 --> 02:01:45,927
WITH PEOPLE FREE OF KNEE PAIN.

2888
02:01:45,927 --> 02:01:47,996
MOST STUDIES ARE IN PEOPLE WITH

2889
02:01:47,996 --> 02:01:48,196
PAIN.

2890
02:01:48,196 --> 02:01:53,368
CHICKEN AND EGG SESSION. 

2891
02:01:53,368 --> 02:01:53,702
 SITUATION.

2892
02:01:53,702 --> 02:01:55,237
WE WANTED TO UNDERSTAND WHAT

2893
02:01:55,237 --> 02:01:56,238
FACTORS MIGHT CONTRIBUTE TO

2894
02:01:56,238 --> 02:01:57,873
TRANSITION FROM BEING FREE OF

2895
02:01:57,873 --> 02:01:59,274
PERSISTENT KNEE PAIN TO

2896
02:01:59,274 --> 02:02:00,142
DEVELOPING CHRONIC PAIN.

2897
02:02:00,142 --> 02:02:05,514
WE OF COURSE LOOKED AT OUR QSC

2898
02:02:05,514 --> 02:02:07,149
MARKS AND FACTORS ASSOCIATED

2899
02:02:07,149 --> 02:02:11,086
WITH PAIN EXPERIENCE, I'M HAVING

2900
02:02:11,086 --> 02:02:11,953
WIDESPREAD PAIN ALREADY, MOOD

2901
02:02:11,953 --> 02:02:13,522
ISSUES, POOR SLEEP, ET CETERA.

2902
02:02:13,522 --> 02:02:15,257
AND SO WE STARTED WITH PEOPLE

2903
02:02:15,257 --> 02:02:17,359
FREE OF KNEE PAIN.

2904
02:02:17,359 --> 02:02:18,360
FOLLOWED THEM OVER TWO YEARS.

2905
02:02:18,360 --> 02:02:20,495
AND WHAT WE FOUND AT THE END OF

2906
02:02:20,495 --> 02:02:22,064
TWO YEARS, PEOPLE MOST

2907
02:02:22,064 --> 02:02:24,032
SENSITIZED BASED ON PRESSURE

2908
02:02:24,032 --> 02:02:25,667
PAIN THRESHOLD MEASURE HAD

2909
02:02:25,667 --> 02:02:27,002
TWO-FOLD INCREASED RISK OF

2910
02:02:27,002 --> 02:02:30,038
DEVELOPING PERSISTENT KNEE PAIN.

2911
02:02:30,038 --> 02:02:32,774
HOW WE DID THIS, USED LATENT

2912
02:02:32,774 --> 02:02:33,542
CLASS ANALYSIS.

2913
02:02:33,542 --> 02:02:35,077
AGNOSTIC APPROACH.

2914
02:02:35,077 --> 02:02:37,913
AND WE IDENTIFIED FOUR CLUSTERS

2915
02:02:37,913 --> 02:02:39,281
OF THESE FEATURES.

2916
02:02:39,281 --> 02:02:40,982
AND THE ONE GROUP THAT I

2917
02:02:40,982 --> 02:02:42,718
MENTIONED ALREADY WAS MOST

2918
02:02:42,718 --> 02:02:43,885
HIGHLY SENSITIZED BY PRESSURE

2919
02:02:43,885 --> 02:02:44,886
PAIN THRESHOLD.

2920
02:02:44,886 --> 02:02:46,621
ANOTHER GROUP HAD A LOT OF

2921
02:02:46,621 --> 02:02:47,522
TEMPORAL SUMMATION.

2922
02:02:47,522 --> 02:02:49,091
WHAT I THOUGHT WAS INTERESTING,

2923
02:02:49,091 --> 02:02:50,926
REASON I'M SHOWING THIS FIGURE,

2924
02:02:50,926 --> 02:02:52,661
OTHER FACTORS THAT WE KNOW

2925
02:02:52,661 --> 02:02:54,229
CONTRIBUTE TO THE PAIN

2926
02:02:54,229 --> 02:02:55,997
EXPERIENCE WERE NOT DIFFERENT

2927
02:02:55,997 --> 02:02:57,299
AMONG THESE FOUR CLUSTERS.

2928
02:02:57,299 --> 02:03:01,470
AND WHEN WE DID ANALYSES THESE

2929
02:03:01,470 --> 02:03:04,639
OTHER CLASSES HAD NULL

2930
02:03:04,639 --> 02:03:05,407
RELATIONSHIPS WITH DEVELOPING

2931
02:03:05,407 --> 02:03:06,608
PERSISTENT KNEE PAIN.

2932
02:03:06,608 --> 02:03:09,678
SO THIS STARTS TO GET A HINT

2933
02:03:09,678 --> 02:03:10,979
THAT WHATEVER WE'RE MEASURING

2934
02:03:10,979 --> 02:03:13,081
WITH PRESSURE PAIN THRESHOLD

2935
02:03:13,081 --> 02:03:15,917
SEEMS TO BE INHERENT TRAIT THAT

2936
02:03:15,917 --> 02:03:16,785
PRECEDES DEVELOPMENT OF

2937
02:03:16,785 --> 02:03:17,986
PERSISTENT KNEE PAIN.

2938
02:03:17,986 --> 02:03:22,157
WHEN THIS WAS PRESENTED TO NIH

2939
02:03:22,157 --> 02:03:23,258
PAIN MEETING IN 2019, THEY SAID

2940
02:03:23,258 --> 02:03:25,260
THIS WAS LIKE ONE OF THE MOST

2941
02:03:25,260 --> 02:03:26,328
IMPORTANT INSIGHTS FOR

2942
02:03:26,328 --> 02:03:27,195
UNDERSTANDING THE TRANSITION

2943
02:03:27,195 --> 02:03:32,701
FROM ACUTE TO CHRONIC PAIN.

2944
02:03:32,701 --> 02:03:34,569
IS THIS AN INHERENT TRAIT?

2945
02:03:34,569 --> 02:03:35,771
ANOTHER ADVANTAGE OF HAVING

2946
02:03:35,771 --> 02:03:38,073
LONGITUDINAL DATA FROM THE MOST

2947
02:03:38,073 --> 02:03:38,840
STUDY, HAVING THIS FUNDING

2948
02:03:38,840 --> 02:03:42,444
CONTINUE, IS THAT WE HAVE A RICH

2949
02:03:42,444 --> 02:03:43,979
LONGITUDINAL DATASET TO PULL

2950
02:03:43,979 --> 02:03:47,783
FROM, TO ASK IN THESE TYPES OF

2951
02:03:47,783 --> 02:03:48,049
QUESTIONS.

2952
02:03:48,049 --> 02:03:50,752
AND SO BECAUSE IT SEEMS THAT

2953
02:03:50,752 --> 02:03:52,020
PAIN SENSITIZATION PRECEDES

2954
02:03:52,020 --> 02:03:53,188
ONSET OF PERSISTENT KNEE PAIN,

2955
02:03:53,188 --> 02:03:55,457
ET CETERA, WE TOOK A LOOK AT OUR

2956
02:03:55,457 --> 02:03:58,093
DATA LONGITUDINALLY AND DID A

2957
02:03:58,093 --> 02:03:59,094
GROUP-BASED TRAJECTORY ANALYSIS.

2958
02:03:59,094 --> 02:04:01,596
AND WE FOUND THAT PEOPLE KIND OF

2959
02:04:01,596 --> 02:04:04,232
CLUSTERED IN HIGH PRESSURE PAIN

2960
02:04:04,232 --> 02:04:05,634
THRESHOLD MEANING LESS

2961
02:04:05,634 --> 02:04:07,202
SENSITIZED MODERATE AND LOW OVER

2962
02:04:07,202 --> 02:04:08,170
A NINE-YEAR PERIOD.

2963
02:04:08,170 --> 02:04:10,906
THIS WAS AN ENTIRE SAMPLE.

2964
02:04:10,906 --> 02:04:14,176
I LIMITED TO PEOPLE FREE OF KNEE

2965
02:04:14,176 --> 02:04:16,578
PAIN AT BASELINE.

2966
02:04:16,578 --> 02:04:24,453
THE FIGURES ARE VIRTUALLY

2967
02:04:24,453 --> 02:04:24,820
SUPERIMPOSABLE.

2968
02:04:24,820 --> 02:04:26,087
THESE GROUPS REMAINED STABLE

2969
02:04:26,087 --> 02:04:27,522
OVER A DECADE, MEANING PEOPLE

2970
02:04:27,522 --> 02:04:29,291
HIGH TO BEGIN WITH DON'T ALL OF

2971
02:04:29,291 --> 02:04:32,227
A SUDDEN TRANSITION TO BECOMING

2972
02:04:32,227 --> 02:04:33,361
MORE SENSITIZED OVER TIME.

2973
02:04:33,361 --> 02:04:38,066
EVEN AMONG PEOPLE WHO ARE FREE 

2974
02:04:38,066 --> 02:04:39,568
OF PAIN AT BASELINE.

2975
02:04:39,568 --> 02:04:41,636
NOW WHAT WE'RE GOING TO DO WITH

2976
02:04:41,636 --> 02:04:45,140
THE NEXT GRANT APPLICATION, TRY

2977
02:04:45,140 --> 02:04:47,342
TO BETTER UNDERSTAND RISK

2978
02:04:47,342 --> 02:04:50,078
FACTORS FOR PAIN SENSITIZATION

2979
02:04:50,078 --> 02:04:51,179
ITSELF.

2980
02:04:51,179 --> 02:04:52,614
MOVING TO CONSEQUENCES OF PAIN

2981
02:04:52,614 --> 02:04:54,916
SENSITIZATION, WE FOUND IT WAS

2982
02:04:54,916 --> 02:04:56,218
ASSOCIATED WITH PAIN SEVERITY,

2983
02:04:56,218 --> 02:04:57,752
EXPECTED AND SEEN IN A LOT OF

2984
02:04:57,752 --> 02:05:00,589
OTHER DISEASES.

2985
02:05:00,589 --> 02:05:03,892
WHAT WE ALSO NEWLY LOOKED AT AND

2986
02:05:03,892 --> 02:05:05,193
IN OSTEOARTHRITIS WITH PAIN

2987
02:05:05,193 --> 02:05:06,728
SENSITIZATION HERE IS EFFECTS ON

2988
02:05:06,728 --> 02:05:07,696
PHYSICAL FUNCTION.

2989
02:05:07,696 --> 02:05:10,999
SO IF WE HAVE ALTERATIONS IN

2990
02:05:10,999 --> 02:05:12,300
ASCENDING FACILITATION

2991
02:05:12,300 --> 02:05:14,703
SIGNALING, DOES THAT SOMEHOW

2992
02:05:14,703 --> 02:05:15,170
IMPACT EFFECTOR MOTOR

2993
02:05:15,170 --> 02:05:15,470
FUNCTIONING?

2994
02:05:15,470 --> 02:05:21,510
AND SO TWO OF MY MENTEES, PAT

2995
02:05:21,510 --> 02:05:22,744
CORRIGAN AND JOSH STEFANICK, ONE

2996
02:05:22,744 --> 02:05:27,115
OF THE K AWARDEES THAT LYNDON

2997
02:05:27,115 --> 02:05:30,218
MENTIONED, LOOKED AT MEDIATION

2998
02:05:30,218 --> 02:05:32,153
ANALYSIS OF WHETHER ANY EFFECT

2999
02:05:32,153 --> 02:05:35,023
OF PAIN SENSITIZATION ON

3000
02:05:35,023 --> 02:05:36,558
PHYSICAL FUNCTION OCCURS

3001
02:05:36,558 --> 02:05:37,659
DIRECTLY NOT THROUGH PAIN

3002
02:05:37,659 --> 02:05:37,926
SEVERITY.

3003
02:05:37,926 --> 02:05:42,597
WE LOOKED AT A VARIETY OF

3004
02:05:42,597 --> 02:05:47,202
FUNCTION OUTCOMES, GAIT, SPEECH,

3005
02:05:47,202 --> 02:05:48,303
CHAIR STANCE, AND QUADRICEP

3006
02:05:48,303 --> 02:05:51,606
STRENGTH AND FOUND FOR EACH OF

3007
02:05:51,606 --> 02:05:52,874
THESE THAT, YES, SOME OF THE

3008
02:05:52,874 --> 02:05:55,410
EFFECTS ON PHYSICAL FUNCTION DUE

3009
02:05:55,410 --> 02:05:57,579
TO PAIN SENSITIZATION ARE

3010
02:05:57,579 --> 02:06:00,015
THROUGH PAIN SEVERITY WILL YOU

3011
02:06:00,015 --> 02:06:01,650
LARGE PROPORTION WAS UNEXPLAINED

3012
02:06:01,650 --> 02:06:04,052
BY PAIN SEVERITY, SO THERE MAY

3013
02:06:04,052 --> 02:06:05,253
BE SOMETHING ELSE, MAYBE

3014
02:06:05,253 --> 02:06:06,821
CORTICAL INTEGRATION OR OTHER

3015
02:06:06,821 --> 02:06:09,190
THINGS WE'RE NOW EXPLORING.

3016
02:06:09,190 --> 02:06:10,725
POST KNEE REPLACEMENT PAIN, SO

3017
02:06:10,725 --> 02:06:13,795
DESPITE THE HUGE MILLIONS OF

3018
02:06:13,795 --> 02:06:16,298
PEOPLE WHO HAVE JOINT

3019
02:06:16,298 --> 02:06:18,934
REPLACEMENTS AS DEFINITIVE BEST

3020
02:06:18,934 --> 02:06:21,903
TREATMENT 20 TO 30% STILL HAVE

3021
02:06:21,903 --> 02:06:23,204
PAIN AFTERWARDS, NOT UNDERSTOOD

3022
02:06:23,204 --> 02:06:27,375
WHY, A HUGE HEALTH BURDEN GIVEN 

3023
02:06:27,375 --> 02:06:30,812
THE NUMBER OF PROCEDURES.

3024
02:06:30,812 --> 02:06:31,613
AOYAGI, NOW AT UNIVERSITY OF

3025
02:06:31,613 --> 02:06:34,149
TEXAS, EL PASO, SUBMITTING HIS

3026
02:06:34,149 --> 02:06:36,084
FIRST K GRANT, LOOKED AT THIS

3027
02:06:36,084 --> 02:06:38,520
WITH ME IN OUR MOST COHORT AND

3028
02:06:38,520 --> 02:06:41,189
WHAT WE FOUND IS THAT TEMPORAL

3029
02:06:41,189 --> 02:06:44,292
SUMMATION WHICH IS THE ASCENDING

3030
02:06:44,292 --> 02:06:46,394
FACILITATION AND INADEQUATE

3031
02:06:46,394 --> 02:06:47,362
DESCENDING MODULATION WERE

3032
02:06:47,362 --> 02:06:49,331
ASSOCIATED WITH HAVING MORE PAIN

3033
02:06:49,331 --> 02:06:51,099
POST KNEE REPLACEMENT.

3034
02:06:51,099 --> 02:06:52,300
SO CENTRAL PAIN MECHANISMS SEEM

3035
02:06:52,300 --> 02:06:54,035
TO BE AT PLAY IN EXPLAINING AT

3036
02:06:54,035 --> 02:06:56,338
LEAST IN PART WHY SOME PEOPLE

3037
02:06:56,338 --> 02:07:00,275
HAVE PERSISTENT PAIN POST KNEE

3038
02:07:00,275 --> 02:07:01,309
REPLACEMENT DESPITE REMOVING THE

3039
02:07:01,309 --> 02:07:03,878
NOXIOUS PATHOLOGIC TISSUE AT THE

3040
02:07:03,878 --> 02:07:05,213
PERIPHERY THAT IS SUPPOSEDLY

3041
02:07:05,213 --> 02:07:07,048
CONTRIBUTING TO THAT PAIN

3042
02:07:07,048 --> 02:07:07,349
EXPERIENCE.

3043
02:07:07,349 --> 02:07:10,452
SO NOW I'M GOING TO MOVE TO THE

3044
02:07:10,452 --> 02:07:11,419
FRAMINGHAM STUDY.

3045
02:07:11,419 --> 02:07:14,956
AND LOOKING AT CHRONIC PAIN IN

3046
02:07:14,956 --> 02:07:16,257
OLDER ADULTS IRRESPECTIVE OF

3047
02:07:16,257 --> 02:07:17,959
PAIN DIAGNOSES.

3048
02:07:17,959 --> 02:07:20,095
IN MEDICINE IF HAVE YOU KNEE

3049
02:07:20,095 --> 02:07:30,605
PAIN, YOU GO TO RHEUMATOLOGY,

3050
02:07:31,106 --> 02:07:32,240
ANATOMIC BASED MANAGEMENT.

3051
02:07:32,240 --> 02:07:34,442
WE TOOK THE PERSPECTIVE MAYBE

3052
02:07:34,442 --> 02:07:35,877
THESE ARE ALL PHENOTYPIC

3053
02:07:35,877 --> 02:07:38,146
EXPRESSIONS OF THE SAME

3054
02:07:38,146 --> 02:07:38,847
UNDERLYING MECHANISM.

3055
02:07:38,847 --> 02:07:41,549
AND SO THIS WAS THE FIRST

3056
02:07:41,549 --> 02:07:42,851
ANCILLARY STUDY IN FRAMINGHAM TO

3057
02:07:42,851 --> 02:07:44,052
LOOK SPECIFICALLY AT PAIN.

3058
02:07:44,052 --> 02:07:47,255
WE JUST FINISHED IN THE FIELD OF

3059
02:07:47,255 --> 02:07:50,025
EXAM 10 OF GENERATION 2, AND

3060
02:07:50,025 --> 02:07:51,192
WE'RE JUST STARTING TO ANALYZE

3061
02:07:51,192 --> 02:07:51,660
DATA.

3062
02:07:51,660 --> 02:07:55,030
I'LL SHOW A LITTLE BIT.

3063
02:07:55,030 --> 02:07:57,732
SO, THE OVERALL ARCHING THEME OF

3064
02:07:57,732 --> 02:07:59,501
THIS STUDY TO UNDERSTAND CHRONIC

3065
02:07:59,501 --> 02:08:01,770
PAIN BUT PARTICULARLY CHRONIC

3066
02:08:01,770 --> 02:08:02,904
OVERLAPPING PAIN SITES BECAUSE

3067
02:08:02,904 --> 02:08:04,205
IN OLDER ADULTS THEY DON'T HAVE

3068
02:08:04,205 --> 02:08:05,407
PAIN IN JUST ONE LOCATION.

3069
02:08:05,407 --> 02:08:07,475
THEY HAVE PAIN IN MANY

3070
02:08:07,475 --> 02:08:11,212
LOCATIONS. 

3071
02:08:11,212 --> 02:08:15,817
SO WE HAD 1600 INDIVIDUALS IN 

3072
02:08:15,817 --> 02:08:21,456
OUR STUDY, MEAN AGE 75.5, RANGE

3073
02:08:21,456 --> 02:08:22,057
52 TO 100.

3074
02:08:22,057 --> 02:08:24,025
IN THE WORLD THIS IS THE OLDEST

3075
02:08:24,025 --> 02:08:28,730
AGE OF A COHORT THAT EVER HAD

3076
02:08:28,730 --> 02:08:31,366
PAIN STUDIED, 55% WAS FEMALE,

3077
02:08:31,366 --> 02:08:33,668
OVER 50% REPORTED HAVING CHRONIC

3078
02:08:33,668 --> 02:08:34,102
PAIN.

3079
02:08:34,102 --> 02:08:36,271
ABOUT A THIRD REPORTED A PAIN

3080
02:08:36,271 --> 02:08:38,239
SEVERITY OF AT LEAST 4 TO 10.

3081
02:08:38,239 --> 02:08:40,108
THE REASON THAT'S IMPORTANT IS

3082
02:08:40,108 --> 02:08:41,743
THAT'S THE MINIMUM PAIN

3083
02:08:41,743 --> 02:08:43,611
THRESHOLD FOR ENROLLING IN PAIN

3084
02:08:43,611 --> 02:08:44,679
TRIALS.

3085
02:08:44,679 --> 02:08:46,114
A THIRD OF OLDER ADULTS HAVE

3086
02:08:46,114 --> 02:08:49,951
SUFFICIENT PAIN TO BE ENROLLED 

3087
02:08:49,951 --> 02:08:51,386
IF THEY MET INCLUSIONS AND

3088
02:08:51,386 --> 02:08:53,021
INCLUDED PEOPLE OF THIS AGE

3089
02:08:53,021 --> 02:08:53,221
RANGE.

3090
02:08:53,221 --> 02:08:55,223
A THIRD HAVE CHRONIC OVERLAPPING

3091
02:08:55,223 --> 02:08:56,424
PAIN CONDITIONS, THREE OR MORE

3092
02:08:56,424 --> 02:08:57,025
PAIN CONDITIONS.

3093
02:08:57,025 --> 02:08:58,727
THE NEXT PART OF THE FIGURE IS

3094
02:08:58,727 --> 02:08:59,360
VERY BUSY.

3095
02:08:59,360 --> 02:09:00,962
I'M SHOWING ALL THE DIFFERENT

3096
02:09:00,962 --> 02:09:02,630
SITES OF PAIN, THEY HAVE ALL

3097
02:09:02,630 --> 02:09:04,933
OVER THEIR BODY, AND IN RED

3098
02:09:04,933 --> 02:09:06,367
HIGHLIGHTING LOW BACK, KNEE,

3099
02:09:06,367 --> 02:09:09,337
HAND, AS EXPECTED LOW BACK AND

3100
02:09:09,337 --> 02:09:10,672
KNEE, THE HAND BEING PREVALENT

3101
02:09:10,672 --> 02:09:12,240
IS A NOVEL FINDING.

3102
02:09:12,240 --> 02:09:14,142
I'LL REITERATE AGAIN I GO TO

3103
02:09:14,142 --> 02:09:16,344
PAIN MEETINGS THERE'S VIRTUALLY

3104
02:09:16,344 --> 02:09:17,312
NOTHING ON OSTEOARTHRITIS, HAND

3105
02:09:17,312 --> 02:09:21,049
AND KNEE IN OLDER ADULTS IS

3106
02:09:21,049 --> 02:09:21,649
PREDOMINANTLY OSTEOARTHRITIS,

3107
02:09:21,649 --> 02:09:23,885
VERY UNDERSTUDIED AREA OF PAIN

3108
02:09:23,885 --> 02:09:25,620
IN OLDER ADULTS.

3109
02:09:25,620 --> 02:09:27,288
HOT OFF THE PRESSES, I GOT THIS

3110
02:09:27,288 --> 02:09:31,426
A COUPLE DAYS AGO, IT'S A VERY

3111
02:09:31,426 --> 02:09:32,427
NOVEL FINDING, THAT BECAUSE OF

3112
02:09:32,427 --> 02:09:35,029
THE AGE RANGE OF OUR COHORT

3113
02:09:35,029 --> 02:09:36,798
WE'RE ABLE TO -- FOR THE FIRST

3114
02:09:36,798 --> 02:09:41,302
TIME ABLE TO SEE PRESSURE PAIN

3115
02:09:41,302 --> 02:09:42,470
THRESHOLD, PAIN SENSITIZATION,

3116
02:09:42,470 --> 02:09:43,371
WORSENS WITH AGE.

3117
02:09:43,371 --> 02:09:46,541
THIS APPEARS TO BE MORE SO IN

3118
02:09:46,541 --> 02:09:51,146
MEN THAN WOMEN, PERHAPS SEEING

3119
02:09:51,146 --> 02:09:54,649
THE TREND IN MEN BECAUSE WOMEN

3120
02:09:54,649 --> 02:09:57,252
HAVE A LOWER THRESHOLD TO BEGIN

3121
02:09:57,252 --> 02:09:57,452
WITH.

3122
02:09:57,452 --> 02:09:59,254
NOW WE'RE ABOUT TO EMBARK,

3123
02:09:59,254 --> 02:10:00,989
SUBMITTING A GRANT TO GET

3124
02:10:00,989 --> 02:10:02,757
FUNDING TO EMBARK ON

3125
02:10:02,757 --> 02:10:05,393
LONGITUDINAL ASSESSMENT OF PAIN

3126
02:10:05,393 --> 02:10:07,595
PHENOTYPES IN THIS FRAMINGHAM

3127
02:10:07,595 --> 02:10:08,763
COHORT, AND TO UNDERSTAND

3128
02:10:08,763 --> 02:10:09,998
UNDERLYING RISK FACTORS FOR NOT

3129
02:10:09,998 --> 02:10:13,168
ONLY CHRONIC PAIN IN OVERLAPPING

3130
02:10:13,168 --> 02:10:14,602
PAIN CONDITIONS BUT REALLY

3131
02:10:14,602 --> 02:10:16,671
DELVING INTO THE PAIN

3132
02:10:16,671 --> 02:10:18,406
SENSITIZATION AS INHERENT TRAIT,

3133
02:10:18,406 --> 02:10:20,175
WHAT ARE RISK FACTORS UNDERLYING

3134
02:10:20,175 --> 02:10:21,376
ALL OF THIS?

3135
02:10:21,376 --> 02:10:26,748
WE'LL LEVERAGE THE RICH DATA IN

3136
02:10:26,748 --> 02:10:27,749
FRAMINGHAM, INCLUDING COGNITIVE

3137
02:10:27,749 --> 02:10:31,052
FUNCTION MEASURES THAT ARE

3138
02:10:31,052 --> 02:10:31,686
THERE, GENETIC

3139
02:10:31,686 --> 02:10:34,522
PROTEOMIC, ET CETERA, IT'S BEEN

3140
02:10:34,522 --> 02:10:36,057
VERY UNDERSTUDIED AS TO WHAT ARE

3141
02:10:36,057 --> 02:10:37,959
THE TRUE RISK FACTORS FOR

3142
02:10:37,959 --> 02:10:39,427
CHRONIC PAIN.

3143
02:10:39,427 --> 02:10:43,832
AND SO IN SUMMARY, PAIN IS MULTI

3144
02:10:43,832 --> 02:10:44,265
FACTORIAL.

3145
02:10:44,265 --> 02:10:45,466
WE NEED TO CONSIDER OTHER

3146
02:10:45,466 --> 02:10:47,235
CONTRIBUTORS OTHER THAN WHAT WE

3147
02:10:47,235 --> 02:10:50,071
THINK THE DIAGNOSIS IS.

3148
02:10:50,071 --> 02:10:53,107
WE NEED MUCH MORE OPTIONS FOR

3149
02:10:53,107 --> 02:10:54,509
DISEASE MODIFICATION IN PAIN

3150
02:10:54,509 --> 02:10:54,809
MANAGEMENT.

3151
02:10:54,809 --> 02:10:56,945
I DID NOT HAVE TIME TO SHOW YOU

3152
02:10:56,945 --> 02:11:00,114
SOME DATA ABOUT HOW

3153
02:11:00,114 --> 02:11:01,416
ARTHRITIS-RELATED CONDITIONS

3154
02:11:01,416 --> 02:11:03,084
HAVE CONTRIBUTED TO A MARKED

3155
02:11:03,084 --> 02:11:03,952
RISE IN OPIOID PRESCRIPTIONS IN

3156
02:11:03,952 --> 02:11:06,254
THE U.S.

3157
02:11:06,254 --> 02:11:08,656
AND HAVE LIKELY CONTRIBUTED TO

3158
02:11:08,656 --> 02:11:10,391
THE OPIOID EPIDEMIC WITH

3159
02:11:10,391 --> 02:11:12,160
OSTEOARTHRITIS AND LOW PAIN

3160
02:11:12,160 --> 02:11:14,662
BEING THE BIGGEST CONTRIBUTORS.

3161
02:11:14,662 --> 02:11:17,298
WE NEED A MECHANISM-BASED

3162
02:11:17,298 --> 02:11:17,565
APPROACH.

3163
02:11:17,565 --> 02:11:18,499
ONE-SIZE-FITS-ALL APPROACH HAS

3164
02:11:18,499 --> 02:11:19,667
NOT BEEN EFFECTIVE.

3165
02:11:19,667 --> 02:11:21,102
WITH THAT I'D LIKE TO AGAIN

3166
02:11:21,102 --> 02:11:23,738
REALLY ACKNOWLEDGE IN RED ALL OF

3167
02:11:23,738 --> 02:11:26,241
THE NIA FUNDING THAT HAS FUNDED

3168
02:11:26,241 --> 02:11:28,543
THIS WORK, THE TOP BULLET IS OUR

3169
02:11:28,543 --> 02:11:29,978
CURRENT STUDIES, THE SECOND

3170
02:11:29,978 --> 02:11:32,480
BULLET IS U01 CONTRACT FOR THE

3171
02:11:32,480 --> 02:11:35,016
FIRST THREE CYCLES OF MOST.

3172
02:11:35,016 --> 02:11:36,784
I THANK ALL MY COLLABORATORS AS

3173
02:11:36,784 --> 02:11:36,985
WELL.

3174
02:11:36,985 --> 02:11:39,387
THANK YOU.

3175
02:11:39,387 --> 02:11:44,225
 

3176
02:11:44,225 --> 02:11:45,727
>> THANK YOU VERY MUCH.

3177
02:11:45,727 --> 02:11:46,761
QUESTIONS FROM OUR COUNCIL

3178
02:11:46,761 --> 02:11:49,464
MEMBERS?

3179
02:11:49,464 --> 02:11:51,132
>> I'LL ASK THE FIRST
QUESTION

3180
02:11:51,132 --> 02:11:52,400
BECAUSE IT CAME EARLY IN THE

3181
02:11:52,400 --> 02:11:52,634
TALK.

3182
02:11:52,634 --> 02:11:55,270
I WAS STRUCK BY THE DIFFERENCE

3183
02:11:55,270 --> 02:11:57,906
IN OSTEOARTHRITIS AND LOWER BACK

3184
02:11:57,906 --> 02:11:59,274
PAIN INDICES BETWEEN JAPAN AND

3185
02:11:59,274 --> 02:12:01,709
EUROPE AND THE UNITED STATES.

3186
02:12:01,709 --> 02:12:04,078
AND WHAT IS KIND OF THE THINKING

3187
02:12:04,078 --> 02:12:05,880
BEHIND THAT, SOME OF THE

3188
02:12:05,880 --> 02:12:07,181
EXPLANATION FOR WHY WE SEE SUCH

3189
02:12:07,181 --> 02:12:10,051
A DISCREPANCY BETWEEN THE

3190
02:12:10,051 --> 02:12:10,485
MEASURES THERE?

3191
02:12:10,485 --> 02:12:11,986
>> SO THANK YOU FOR THAT

3192
02:12:11,986 --> 02:12:12,253
QUESTION.

3193
02:12:12,253 --> 02:12:15,823
THAT HAS BEEN AN AREA OF ACTIVE

3194
02:12:15,823 --> 02:12:16,424
RESEARCH.

3195
02:12:16,424 --> 02:12:19,694
THE TWO MAIN HYPOTHESES ARE

3196
02:12:19,694 --> 02:12:22,397
OBESITY AND PHYSICAL ACTIVITY.

3197
02:12:22,397 --> 02:12:24,365
AND THE COHORTS FROM JAPAN THAT

3198
02:12:24,365 --> 02:12:26,467
CONTRIBUTED TO THROWS TYPES OF

3199
02:12:26,467 --> 02:12:28,536
STUDIES HAVE BEEN IN PARTS OF

3200
02:12:28,536 --> 02:12:30,972
JAPAN WHERE PEOPLE ARE

3201
02:12:30,972 --> 02:12:33,041
PHYSICALLY ACTIVE IN DAILY

3202
02:12:33,041 --> 02:12:34,709
LIVES, EVEN INTO OLDER AGES.

3203
02:12:34,709 --> 02:12:37,412
SO THOSE ARE THE TWO PREVAILING

3204
02:12:37,412 --> 02:12:37,879
HYPOTHESES.

3205
02:12:37,879 --> 02:12:39,847
SOME ABOUT DIET AS WELL BUT I

3206
02:12:39,847 --> 02:12:42,383
THINK THAT ALL CONTRIBUTES TO

3207
02:12:42,383 --> 02:12:45,086
METABOLIC HEALTH AND OBESITY.

3208
02:12:45,086 --> 02:12:47,855
 

3209
02:12:47,855 --> 02:12:48,723
>> VERY NICE TALK.

3210
02:12:48,723 --> 02:12:49,357
THANK YOU.

3211
02:12:49,357 --> 02:12:50,792
TWO QUESTIONS.

3212
02:12:50,792 --> 02:12:53,728
ONE WAS RELATED TO EXERCISE.

3213
02:12:53,728 --> 02:12:55,797
WONDERING HOW EXERCISE AFFECTS

3214
02:12:55,797 --> 02:12:58,333
THE PAIN THRESHOLDS AND PAIN

3215
02:12:58,333 --> 02:13:00,501
MECHANISMS, I GUESS YOU COULD

3216
02:13:00,501 --> 02:13:02,370
ASK ABOUT HOW EXERCISE AFFECTS

3217
02:13:02,370 --> 02:13:03,037
OSTEOARTHRITIS, I'VE BEEN SEEING

3218
02:13:03,037 --> 02:13:05,106
ARTICLES IN THE LAST FEW YEARS

3219
02:13:05,106 --> 02:13:06,541
HOW EXERCISE IS ACTUALLY GOOD

3220
02:13:06,541 --> 02:13:08,509
FOR THAT, PEOPLE USED TO THINK I

3221
02:13:08,509 --> 02:13:09,577
CAN'T EXERCISE, I DON'T KNOW

3222
02:13:09,577 --> 02:13:11,646
WHAT YOUR THOUGHTS ARE ON THAT.

3223
02:13:11,646 --> 02:13:13,448
YEAH, HOW IT AFFECTS THE PAIN

3224
02:13:13,448 --> 02:13:14,248
THRESHOLD AS WELL.

3225
02:13:14,248 --> 02:13:16,050
>> SURE, THANK YOU FOR
THAT

3226
02:13:16,050 --> 02:13:16,517
QUESTION.

3227
02:13:16,517 --> 02:13:17,485
YES, ABSOLUTELY, THERE'S LOTS OF

3228
02:13:17,485 --> 02:13:20,888
VERY GOOD DATA THAT EXERCISE IS

3229
02:13:20,888 --> 02:13:25,159
BENEFICIAL FOR OSTEOARTHRITIS.

3230
02:13:25,159 --> 02:13:27,228
THAT HEALTHY EXERCISE MEANS

3231
02:13:27,228 --> 02:13:28,229
AVOIDING INJURY TO THE JOINTS,

3232
02:13:28,229 --> 02:13:29,430
BENEFITS THE JOINT.

3233
02:13:29,430 --> 02:13:34,802
THE JOINT NEEDS SOME DEGREE OF

3234
02:13:34,802 --> 02:13:35,403
LOADING, UNDERLOADING FOSTERS

3235
02:13:35,403 --> 02:13:36,704
ARTHRITIS, LOTS OF GOOD EVIDENCE

3236
02:13:36,704 --> 02:13:37,672
FOR EXERCISE.

3237
02:13:37,672 --> 02:13:40,041
WITH REGARDS TO HOW EXERCISE

3238
02:13:40,041 --> 02:13:42,143
AFFECTS PAIN THRESHOLDS, THAT IS

3239
02:13:42,143 --> 02:13:44,345
ONE OF OUR PROJECTS FROM THE U19

3240
02:13:44,345 --> 02:13:46,414
NOW THAT WE'RE STUDYING.

3241
02:13:46,414 --> 02:13:48,249
THERE'S A CONCEPT OF RUNNER'S

3242
02:13:48,249 --> 02:13:48,616
HIGH.

3243
02:13:48,616 --> 02:13:52,286
SO FOR MANY PEOPLE WHEN THEY RUN

3244
02:13:52,286 --> 02:13:54,856
THEY FEEL BETTER, THEY HAVE LESS

3245
02:13:54,856 --> 02:13:57,358
PAIN, THEY FEEL EUPHORIA.

3246
02:13:57,358 --> 02:13:59,027
PROBABLY FROM RELEASE OF

3247
02:13:59,027 --> 02:14:00,094
ENDOGENOUS OPIOID PATHWAYS.

3248
02:14:00,094 --> 02:14:03,931
SOME PEOPLE DON'T FEEL THAT.

3249
02:14:03,931 --> 02:14:08,636
AND SO THERE IS A PARADIGM OF

3250
02:14:08,636 --> 02:14:10,371
EXERCISE-INDUCED HYPO ALGESIA,

3251
02:14:10,371 --> 02:14:12,340
YOU FEEL LESS PAIN, PAIN RELIEF

3252
02:14:12,340 --> 02:14:13,007
WITH EXERCISE.

3253
02:14:13,007 --> 02:14:15,209
BUT SOME PEOPLE HAVE NO

3254
02:14:15,209 --> 02:14:16,377
IMPROVEMENT OR WORSENING.

3255
02:14:16,377 --> 02:14:18,279
SO WE'RE STUDYING THAT RIGHT NOW

3256
02:14:18,279 --> 02:14:21,215
TO TRY TO UNDERSTAND.

3257
02:14:21,215 --> 02:14:22,083
THAT'S REALLY IMPORTANT

3258
02:14:22,083 --> 02:14:23,518
THERAPEUTICALLY BECAUSE THE

3259
02:14:23,518 --> 02:14:25,153
FIRST LINE MANAGEMENT FOR

3260
02:14:25,153 --> 02:14:26,020
OSTEOARTHRITIS IS EXERCISE AND

3261
02:14:26,020 --> 02:14:26,988
PHYSICAL THERAPY.

3262
02:14:26,988 --> 02:14:28,322
BUT WE MAY BE SETTING UP A

3263
02:14:28,322 --> 02:14:30,191
NUMBER OF PATIENTS FOR FAILURE

3264
02:14:30,191 --> 02:14:34,128
BY SENDING THEM FOR FAILURE THAT

3265
02:14:34,128 --> 02:14:35,663
NEURONAL MECHANISMS ARE NOT SET

3266
02:14:35,663 --> 02:14:39,267
UP TO TAKE ADVANTAGE OF.

3267
02:14:39,267 --> 02:14:43,004
SO UNDERSTUDIED AREA, MOST

3268
02:14:43,004 --> 02:14:46,607
STUDIES HAVE BEEN HANDFUL OF

3269
02:14:46,607 --> 02:14:47,708
PEOPLE, THEY SHORT PROTOCOLS.

3270
02:14:47,708 --> 02:14:50,645
WE'VE DELVING INTO THE IMPORTANT

3271
02:14:50,645 --> 02:14:50,912
QUESTION.

3272
02:14:50,912 --> 02:14:54,148
>> ONE AREA MORE ON
BIOMARKERS,

3273
02:14:54,148 --> 02:14:56,317
IF YOU HAD SYNOVIAL FLUID AND

3274
02:14:56,317 --> 02:14:57,885
COULD DO PROTEOMICS, IF THE KNEE

3275
02:14:57,885 --> 02:14:59,053
HAS AN EFFUSION IT CAN BE

3276
02:14:59,053 --> 02:15:02,890
HAPPENED, I DON'T KNOW WHAT THE

3277
02:15:02,890 --> 02:15:04,225
ETHICS ARE FOR TAPPING A KNEE

3278
02:15:04,225 --> 02:15:05,960
WITHOUT EFFUSION BUT YOU'VE GOT

3279
02:15:05,960 --> 02:15:07,595
PHYSIOLOGY NOW.

3280
02:15:07,595 --> 02:15:09,497
CAN YOU BRING FLUID-BASED

3281
02:15:09,497 --> 02:15:11,632
BIOMARKERS INTO THESE STUDIES?

3282
02:15:11,632 --> 02:15:14,836
>> SO THE FIRST QUESTION,
ONE OF

3283
02:15:14,836 --> 02:15:16,571
THE U19, SECOND IS PROJECT TWO.

3284
02:15:16,571 --> 02:15:19,540
LET'S SEE IF YOU GET THE

3285
02:15:19,540 --> 02:15:22,810
JACKPOT, ALL THREE.

3286
02:15:22,810 --> 02:15:24,045
>> NOT A RHEUMATOLOGIST.

3287
02:15:24,045 --> 02:15:26,948
>> PROJECT 2 IN THE U19 IS

3288
02:15:26,948 --> 02:15:28,049
EXACTLY THAT.

3289
02:15:28,049 --> 02:15:31,686
ON ULTRASOUND EVEN IN A HEALTHY

3290
02:15:31,686 --> 02:15:33,387
KNEE THERE'S SMALL VOLUME.

3291
02:15:33,387 --> 02:15:35,823
BUT WHAT WE'RE DOING IS

3292
02:15:35,823 --> 02:15:39,794
SCREENING ALL KNEES WITH BEDSIDE

3293
02:15:39,794 --> 02:15:40,094
ULTRASOUND.

3294
02:15:40,094 --> 02:15:41,429
THOSE WITH SUFFICIENT VOLUME

3295
02:15:41,429 --> 02:15:48,636
EVEN TO GET ONE C.C. THEY WILL 

3296
02:15:48,636 --> 02:15:50,538
UNDERGO ULTRASOUND-GUIDED

3297
02:15:50,538 --> 02:15:52,573
ULTRASOUND AND WE'LL HAVE

3298
02:15:52,573 --> 02:15:55,243
PROTEOMICS DONE, PART OF A

3299
02:15:55,243 --> 02:15:56,777
LARGER WORLDWIDE EFFORT WHERE

3300
02:15:56,777 --> 02:15:59,280
MANY COHORTS AROUND THE WORLD

3301
02:15:59,280 --> 02:16:00,047
ARE ATTEMPTING TO DO THIS.

3302
02:16:00,047 --> 02:16:03,551
OURS WILL BE VERY UNIQUE BECAUSE

3303
02:16:03,551 --> 02:16:05,086
MOST OTHER COHORTS HAVE LATE

3304
02:16:05,086 --> 02:16:05,620
STABLED ESTABLISHED

3305
02:16:05,620 --> 02:16:05,987
OSTEOARTHRITIS.

3306
02:16:05,987 --> 02:16:08,456
WE HAVE A BROAD RANGE FROM NO

3307
02:16:08,456 --> 02:16:10,424
O.A., EARLY O.A., TO LATE O.A.

3308
02:16:10,424 --> 02:16:13,294
>> THANK YOU.

3309
02:16:13,294 --> 02:16:15,496
>> THIS IS ALL REALLY
EXCITING.

3310
02:16:15,496 --> 02:16:19,467
I WAS WONDERING IF YOU HAD AN

3311
02:16:19,467 --> 02:16:22,370
OPINION ON THE WORK BY LIKE

3312
02:16:22,370 --> 02:16:24,238
NAOMI EISSENBERGER AND TEAMS

3313
02:16:24,238 --> 02:16:26,307
THAT LOOK AT THE MIND-BODY

3314
02:16:26,307 --> 02:16:35,616
CONNECTION AND WHEN SHE PUTS 

3315
02:16:35,616 --> 02:16:38,886
PEOPLE IN fMRIs, PLAYS

3316
02:16:38,886 --> 02:16:40,021
PASS-THE-BALL, YOU STOP, THE

3317
02:16:40,021 --> 02:16:41,656
SAME PART OF THE BRAIN LIGHTS UP

3318
02:16:41,656 --> 02:16:44,158
WHEN THE PERSON IS IN PAIN, HOW

3319
02:16:44,158 --> 02:16:45,893
THAT CONTRIBUTES OR DOESN'T OR

3320
02:16:45,893 --> 02:16:48,963
IF YOU DISMISS THAT WORK OR JUST

3321
02:16:48,963 --> 02:16:51,165
GREAT TO HAVE YOUR OPINION ON

3322
02:16:51,165 --> 02:16:51,499
THAT.

3323
02:16:51,499 --> 02:16:55,002
>> FULL DISCLOSURE I DON'T
DO

3324
02:16:55,002 --> 02:16:58,372
fMRI STUDIES SO I WON'T SEEK

3325
02:16:58,372 --> 02:17:00,041
SCIENTIFICALLY ABOUT IT BUT

3326
02:17:00,041 --> 02:17:02,310
THERE'S DEFINITELY GOOD DATA.

3327
02:17:02,310 --> 02:17:03,844
BASIS FOR COGNITIVE BEHAVIORAL

3328
02:17:03,844 --> 02:17:06,581
THERAPY, SO THERE'S GOOD DATA

3329
02:17:06,581 --> 02:17:08,349
ABOUT LEVERAGING THOSE MIND-BODY

3330
02:17:08,349 --> 02:17:09,417
CONNECTIONs FOR PAIN

3331
02:17:09,417 --> 02:17:09,717
MANAGEMENT.

3332
02:17:09,717 --> 02:17:13,254
AND THE AREAS IN THE BRAIN THAT

3333
02:17:13,254 --> 02:17:16,891
LIGHT UP WITH RESPECT TO NOXIOUS

3334
02:17:16,891 --> 02:17:18,993
STIMULUS AND/OR JUST MOVING A

3335
02:17:18,993 --> 02:17:20,494
PAINFUL JOINT, THOSE SAME AREAS

3336
02:17:20,494 --> 02:17:23,197
CAN BE LIT UP BY SHOWING SOMEONE

3337
02:17:23,197 --> 02:17:26,601
AN IMAGE OF SOMETHING PAINFUL.

3338
02:17:26,601 --> 02:17:28,536
WHETHER IT'S EXPECTATION OR

3339
02:17:28,536 --> 02:17:29,770
ACTUAL NOCICEPTIVE INPUT I THINK

3340
02:17:29,770 --> 02:17:34,375
HAS BEEN MORE DIFFICULT TO

3341
02:17:34,375 --> 02:17:36,344
DISENTANGLE BUT NONETHELESS I

3342
02:17:36,344 --> 02:17:37,311
RECOMMEND MINDFULNESS BASED

3343
02:17:37,311 --> 02:17:39,080
STRESS REDUCTION FOR ALL MY

3344
02:17:39,080 --> 02:17:40,481
PATIENTS WHO HAVE PAIN.

3345
02:17:40,481 --> 02:17:42,683
EVEN IF WE DON'T REALLY

3346
02:17:42,683 --> 02:17:44,852
UNDERSTAND THE MECHANISM BUT

3347
02:17:44,852 --> 02:17:46,387
THERE'S ENOUGH DATA TO SUGGEST

3348
02:17:46,387 --> 02:17:52,627
IN A VARIETY OF CHRONIC PAIN

3349
02:17:52,627 --> 02:17:56,464
SETTINGS THAT ALTERING ONE'S

3350
02:17:56,464 --> 02:17:58,866
APPROACH AND WHETHER IT'S

3351
02:17:58,866 --> 02:18:03,237
ACHIEVABLE BY DIFFERENT FORMS OF

3352
02:18:03,237 --> 02:18:05,106
MEDITATION, THERE HAVE BEEN NICE

3353
02:18:05,106 --> 02:18:06,540
SMALL STUDIES SHOWING CHANGES IN

3354
02:18:06,540 --> 02:18:10,444
WHAT'S LIGHTING UP AFTER

3355
02:18:10,444 --> 02:18:12,747
SOMEONE'S DONE A STABLE

3356
02:18:12,747 --> 02:18:14,282
PROLONGED MEDITATION PRACTICE,

3357
02:18:14,282 --> 02:18:15,816
AND THEY ARE EXPERIENCING LESS

3358
02:18:15,816 --> 02:18:16,017
PAIN.

3359
02:18:16,017 --> 02:18:18,786
SINCE IT'S FREE AND HAS NO HARM,

3360
02:18:18,786 --> 02:18:21,289
WHY NOT?

3361
02:18:21,289 --> 02:18:24,659
 

3362
02:18:24,659 --> 02:18:26,861
>> I WONDER IF YOU CAN
MAKE A

3363
02:18:26,861 --> 02:18:32,533
COMMENT ON SOME RECENT EVIDENCE

3364
02:18:32,533 --> 02:18:36,070
THAT ENDORSED SIGNALING IS

3365
02:18:36,070 --> 02:18:40,207
INVOLVED IN OSTEOARTHRITIS,

3366
02:18:40,207 --> 02:18:41,309
PHYSIOLOGY, INHIBITORS COULD BE

3367
02:18:41,309 --> 02:18:43,711
POTENTIAL TREATMENTS FOR THIS

3368
02:18:43,711 --> 02:18:44,712
DISEASE, WHETHER YOU CAN MAKE

3369
02:18:44,712 --> 02:18:46,013
COMMENT.

3370
02:18:46,013 --> 02:18:49,083
>> I'M NOT A BASIC
SCIENTIST,

3371
02:18:49,083 --> 02:18:55,423
CANNOT COMMENT ON WHICH 

3372
02:18:55,423 --> 02:18:56,090
INTRACELLULAR SIGNALING PATHWAYS

3373
02:18:56,090 --> 02:18:57,325
ARE MOST PROMISING.

3374
02:18:57,325 --> 02:19:00,594
THERE HAVE BEEN MANY PROMISING

3375
02:19:00,594 --> 02:19:02,563
TARGETS FOR OSTEOARTHRITIS AND

3376
02:19:02,563 --> 02:19:05,733
PAIN INCLUDING INTRACELLULAR

3377
02:19:05,733 --> 02:19:06,901
SIGNALING PATHWAYS, RECEPTORS ON

3378
02:19:06,901 --> 02:19:07,935
CELL SURFACE, ET CETERA.

3379
02:19:07,935 --> 02:19:10,538
A MAIN CHALLENGE FOR ANY OF

3380
02:19:10,538 --> 02:19:13,074
THESE PROMISING PATHWAYS DESPITE

3381
02:19:13,074 --> 02:19:14,709
HAVING PROMISE IN ANIMAL MODEL

3382
02:19:14,709 --> 02:19:17,345
STUDIES WHEN WE TRANSLATE TO

3383
02:19:17,345 --> 02:19:19,213
CLINICAL HUMAN TRIALS WE HAVE

3384
02:19:19,213 --> 02:19:20,614
MULTIPLE PROBLEMS.

3385
02:19:20,614 --> 02:19:23,584
ONE IS THE STANDARD INCLUSION

3386
02:19:23,584 --> 02:19:25,019
CRITERIA FOR TRIALS IS GRADE 2

3387
02:19:25,019 --> 02:19:29,590
OR 3 WITH PAIN LEVEL OF AT LEAST

3388
02:19:29,590 --> 02:19:31,125
4, THAT'S A VERY HETEROGENEOUS

3389
02:19:31,125 --> 02:19:31,992
POOL OF INDIVIDUALS.

3390
02:19:31,992 --> 02:19:34,562
WE NEED A BETTER WAY OF

3391
02:19:34,562 --> 02:19:36,464
PHENOTYPING INDIVIDUALS SO IF A

3392
02:19:36,464 --> 02:19:37,898
PARTICULAR PATHWAY IS OF

3393
02:19:37,898 --> 02:19:39,433
RELEVANCE THEN THE TRIALS

3394
02:19:39,433 --> 02:19:40,534
ENRICHED WITH THOSE INDIVIDUALS

3395
02:19:40,534 --> 02:19:42,303
GETTING THE RIGHT TREATMENT TO

3396
02:19:42,303 --> 02:19:43,070
THE RIGHT PATHWAY.

3397
02:19:43,070 --> 02:19:46,540
THE OTHER IS IF WE'RE STARTING

3398
02:19:46,540 --> 02:19:48,709
TRIALS AT KL2 OR 3 THAT'S WHEN

3399
02:19:48,709 --> 02:19:50,945
THE HORSE IS AT THE BARN.

3400
02:19:50,945 --> 02:19:52,446
ISN'T REALISTIC TO THINK

3401
02:19:52,446 --> 02:19:54,115
TARGETING A SINGLE MOLECULE OUT

3402
02:19:54,115 --> 02:19:58,652
OF ALL GOING ON IN THE JOINT AND

3403
02:19:58,652 --> 02:20:03,124
THAT INDIVIDUAL'S BODY HABITUS,

3404
02:20:03,124 --> 02:20:04,625
OBESITY, IS GOING TO BE SUCCESS.

3405
02:20:04,625 --> 02:20:07,094
WHAT WE'RE TRYING TO DO IS

3406
02:20:07,094 --> 02:20:07,762
DEVELOP CLASSIFICATION CRITERIA

3407
02:20:07,762 --> 02:20:10,164
FOR EARLIER STAGE O.A. SO

3408
02:20:10,164 --> 02:20:11,365
PROMISING BIOLOGIC TARGETS MAY

3409
02:20:11,365 --> 02:20:15,102
HAVE A BETTER CHANCE OF SHOWING

3410
02:20:15,102 --> 02:20:16,537
SUCCESS THAN AT LATER STAGE,

3411
02:20:16,537 --> 02:20:17,905
ALMOST END STAGE DISEASE.

3412
02:20:17,905 --> 02:20:20,441
I CANNOT SPECIFICALLY COMMENT ON

3413
02:20:20,441 --> 02:20:23,077
YOUR mTOR QUESTION BUT I CAN

3414
02:20:23,077 --> 02:20:27,014
SAY BROADLY THERE ARE MANY

3415
02:20:27,014 --> 02:20:28,516
DEVELOPMENT PROGRAMS FOR

3416
02:20:28,516 --> 02:20:30,451
BIOLOGIC TARGETS BUT I THINK

3417
02:20:30,451 --> 02:20:31,619
WE'RE MISSENING THE SIGNAL FOR

3418
02:20:31,619 --> 02:20:33,387
THE NOISE AND THE WAY IN WHICH

3419
02:20:33,387 --> 02:20:43,898
WE RUN THE TRIALS CLINICALLY. 

3420
02:20:44,632 --> 02:20:49,937
>> DID YOU DO ANY ANALYSIS
BASED

3421
02:20:49,937 --> 02:20:52,873
ON DIFFERENT RACIAL GROUPS, MORE

3422
02:20:52,873 --> 02:20:55,075
INTERESTED AND CURIOUS THERE'S

3423
02:20:55,075 --> 02:20:59,346
SOME STUFF DR. JAMIE RUDY HAS

3424
02:20:59,346 --> 02:21:01,816
DONE, DR. POLLACK, SHOWING THE

3425
02:21:01,816 --> 02:21:06,554
PAIN PROCESSING AMONG NATIVE 

3426
02:21:06,554 --> 02:21:07,455
AMERICANS IS SOMEWHAT DAMPENED,

3427
02:21:07,455 --> 02:21:08,322
DETRIMENTAL BECAUSE THEY DON'T

3428
02:21:08,322 --> 02:21:11,058
SEEK CARE WHEN THEY SHOULD AND

3429
02:21:11,058 --> 02:21:12,393
IT DELAYS AND CAUSES

3430
02:21:12,393 --> 02:21:12,726
COMPLICATIONS.

3431
02:21:12,726 --> 02:21:16,096
>> YES, THANK YOU FOR THAT

3432
02:21:16,096 --> 02:21:16,363
QUESTION.

3433
02:21:16,363 --> 02:21:16,964
MULTI-CENTRAL OSTEOARTHRITIS

3434
02:21:16,964 --> 02:21:19,733
STUDY, A QUARTER TO A THIRD OF

3435
02:21:19,733 --> 02:21:23,571
PARTICIPANTS ARE OF AFRICAN

3436
02:21:23,571 --> 02:21:25,105
AMERICAN BACKGROUND, LAST CYCLE

3437
02:21:25,105 --> 02:21:28,809
WE ATTEMPTED TO INCREASE

3438
02:21:28,809 --> 02:21:30,344
ENROLLMENT OF HISPANIC

3439
02:21:30,344 --> 02:21:31,011
PARTICIPANTS, HISPANIC

3440
02:21:31,011 --> 02:21:31,812
BACKGROUND, CURRENTLY IN THIS

3441
02:21:31,812 --> 02:21:33,113
CYCLE WE'RE GOING TO EXPAND

3442
02:21:33,113 --> 02:21:33,347
FURTHER.

3443
02:21:33,347 --> 02:21:38,352
I DIDN'T GO INTO THAT JUST

3444
02:21:38,352 --> 02:21:39,653
BECAUSE I'M HESITANT, WE START

3445
02:21:39,653 --> 02:21:42,089
TALKING ABOUT HEALTH EQUITY

3446
02:21:42,089 --> 02:21:43,624
TOURISM AND HELICOPTER RESEARCH.

3447
02:21:43,624 --> 02:21:46,327
I'M VERY HESITANT ABOUT JUST

3448
02:21:46,327 --> 02:21:50,297
DOING ANALYSES BASED ON

3449
02:21:50,297 --> 02:21:51,532
SELF-REPORTED RACIAL/ETHNIC

3450
02:21:51,532 --> 02:21:52,600
BACKGROUND BECAUSE WE NEED TO

3451
02:21:52,600 --> 02:21:53,934
ALSO TAKE INTO ACCOUNT

3452
02:21:53,934 --> 02:21:55,769
STRUCTURAL RACISM AND ALL THOSE

3453
02:21:55,769 --> 02:21:57,304
OTHER FACTORS THAT CAN

3454
02:21:57,304 --> 02:21:58,072
CONTRIBUTE.

3455
02:21:58,072 --> 02:22:01,475
SO HAVING SAID THAT, THERE ARE

3456
02:22:01,475 --> 02:22:03,410
DIFFERENCES BETWEEN WHITE

3457
02:22:03,410 --> 02:22:04,745
PARTICIPANTS AND BLACK

3458
02:22:04,745 --> 02:22:06,046
PARTICIPANTS, BUT I DON'T

3459
02:22:06,046 --> 02:22:07,581
PRESENT THOSE YET BECAUSE I

3460
02:22:07,581 --> 02:22:12,086
REALLY WANT TO GET THIS OTHER

3461
02:22:12,086 --> 02:22:13,821
BROADER CONTEXT FOR THAT STORY,

3462
02:22:13,821 --> 02:22:14,788
FOR THAT MESSAGE, BECAUSE I

3463
02:22:14,788 --> 02:22:17,658
THINK IT'S VERY EASY TO JUST

3464
02:22:17,658 --> 02:22:21,262
DICHOTOMIZE AND DO THAT KIND OF

3465
02:22:21,262 --> 02:22:21,529
ANALYSES.

3466
02:22:21,529 --> 02:22:32,072
YOUR POINT ABOUT PEOPLE WHO HAVE

3467
02:22:32,406 --> 02:22:33,173
INADEQUATE PAIN RECEPTION -- I'M

3468
02:22:33,173 --> 02:22:35,409
TRYING TO THINK OF THE RIGHT

3469
02:22:35,409 --> 02:22:38,879
WORD. 

3470
02:22:38,879 --> 02:22:39,313
>> MODULATION.

3471
02:22:39,313 --> 02:22:40,347
>> YES, WE KNOW CHARCOT
JOINT

3472
02:22:40,347 --> 02:22:45,352
AND THINGS LIKE THAT, BOTH ENDS

3473
02:22:45,352 --> 02:22:46,253
ARE PROBLEMATIC, BUT INADEQUATE

3474
02:22:46,253 --> 02:22:47,421
SENSATION CAN LEAD TO

3475
02:22:47,421 --> 02:22:48,155
OVERLOADING THE JOINT, ET

3476
02:22:48,155 --> 02:22:50,324
CETERA.

3477
02:22:50,324 --> 02:22:55,029
 

3478
02:22:55,029 --> 02:22:59,833
>> THIS WAS A REALLY
INFORMATIVE

3479
02:22:59,833 --> 02:23:00,167
PRESENTATION.

3480
02:23:00,167 --> 02:23:05,539
A FEW TIMES YOU SPOKE ABOUT THE

3481
02:23:05,539 --> 02:23:06,907
LIMITATIONS OF THE TRIALS, AND

3482
02:23:06,907 --> 02:23:10,344
SO I WONDER IF YOU COULD, YOU

3483
02:23:10,344 --> 02:23:13,414
KNOW, GIVE US AN OUTLINE JUST

3484
02:23:13,414 --> 02:23:15,616
FROM THE PERSPECTIVE OF COUNCIL

3485
02:23:15,616 --> 02:23:17,718
OF WHAT THESE TRIALS SHOULD LOOK

3486
02:23:17,718 --> 02:23:21,322
LIKE, WHAT ARE THE ELEMENTS, YOU

3487
02:23:21,322 --> 02:23:22,957
KNOW, THE SAMPLE SIZE HAS BEEN

3488
02:23:22,957 --> 02:23:27,461
TOO SMALL, YOU SAID, IN MANY,

3489
02:23:27,461 --> 02:23:28,329
MANY CASES.

3490
02:23:28,329 --> 02:23:33,033
IF YOU'VE, YOU KNOW, SEEN TRIALS

3491
02:23:33,033 --> 02:23:35,970
THAT HAVE, YOU KNOW, ENOUGH

3492
02:23:35,970 --> 02:23:40,808
PEOPLE, ENOUGH TO DO COMPARISONS

3493
02:23:40,808 --> 02:23:42,876
ACROSS SUBGROUPS, ACROSS VARIOUS

3494
02:23:42,876 --> 02:23:44,278
DIFFERENT CLUSTERS YOU'VE

3495
02:23:44,278 --> 02:23:48,983
DEVELOPED, JUST WONDERING IF 

3496
02:23:48,983 --> 02:23:50,751
YOU'VE COME UP WITH A

3497
02:23:50,751 --> 02:23:51,619
COMPREHENSIVE DESCRIPTION OF

3498
02:23:51,619 --> 02:23:53,587
WHAT THESE TRIALS SHOULD BE?

3499
02:23:53,587 --> 02:23:55,756
>> THANK YOU FOR THAT
QUESTION.

3500
02:23:55,756 --> 02:23:57,191
I DO WANT TO MAKE ONE COMMENT

3501
02:23:57,191 --> 02:23:58,859
FOR THE PRIOR QUESTION THAT I

3502
02:23:58,859 --> 02:24:00,060
FORGOT TO MENTION, ANOTHER

3503
02:24:00,060 --> 02:24:05,199
REASON I HAVEN'T DONE TOO MUCH

3504
02:24:05,199 --> 02:24:08,802
WITH UNDERSTANDING THESE PAIN

3505
02:24:08,802 --> 02:24:10,237
MECHANISMS, IN OUR BLACK

3506
02:24:10,237 --> 02:24:10,871
PARTICIPANTS, HISPANIC, ET

3507
02:24:10,871 --> 02:24:12,840
CETERA, WE'RE IN THE FIELD

3508
02:24:12,840 --> 02:24:16,343
PRESENTLY IN JACKSON HEART,

3509
02:24:16,343 --> 02:24:17,678
WHICH IS CARDIOVASCULAR COHORT

3510
02:24:17,678 --> 02:24:19,013
OF AFRICAN AMERICANS, OLDER

3511
02:24:19,013 --> 02:24:21,081
ADULTS, SO ONCE WE HAVE THOSE

3512
02:24:21,081 --> 02:24:24,351
DATA WE'LL HAVE MUCH MORE TO BE

3513
02:24:24,351 --> 02:24:28,188
ABLE TO BASE OUR ANALYSES AND

3514
02:24:28,188 --> 02:24:29,957
DISCUSSIONS ON.

3515
02:24:29,957 --> 02:24:31,058
>> AND JACKSON HEART
ACTUALLY

3516
02:24:31,058 --> 02:24:33,661
COLLECTS A LOT OF THE CONTEXTUAL

3517
02:24:33,661 --> 02:24:36,730
DATA THAT YOU WERE JUST

3518
02:24:36,730 --> 02:24:39,166
MENTIONING FROM THE GET-GO

3519
02:24:39,166 --> 02:24:41,001
INCLUDING EXPERIENCES OF

3520
02:24:41,001 --> 02:24:42,336
DISCRIMINATION AND STRUCTURAL

3521
02:24:42,336 --> 02:24:43,303
RACISM MEASURES AT THE

3522
02:24:43,303 --> 02:24:43,837
NEIGHBORHOOD LEVEL.

3523
02:24:43,837 --> 02:24:46,206
THAT WILL BE GREAT FOR YOUR --

3524
02:24:46,206 --> 02:24:47,474
>> AND THOSE ARE EXACTLY
WHAT

3525
02:24:47,474 --> 02:24:49,643
ARE SOME OF OUR FUNDED AIMS,

3526
02:24:49,643 --> 02:24:52,646
RELATED TO LOOKING AT THOSE.

3527
02:24:52,646 --> 02:24:55,449
AS FOR CLINICAL TRIALS THIS HAS

3528
02:24:55,449 --> 02:24:57,651
BEEN AN ONGOING ISSUE THAT THE

3529
02:24:57,651 --> 02:24:59,086
OSTEOARTHRITIS WORLD HAS BEEN

3530
02:24:59,086 --> 02:25:01,155
TRYING TO TACKLE.

3531
02:25:01,155 --> 02:25:02,222
EACH YEAR AT INTERNATIONAL

3532
02:25:02,222 --> 02:25:06,193
CONFERENCE WHERE WE TRY TO

3533
02:25:06,193 --> 02:25:08,529
TACKLE THIS ISSUE, WE DON'T HAVE

3534
02:25:08,529 --> 02:25:10,030
EASY ANSWERS YET.

3535
02:25:10,030 --> 02:25:11,965
PART OF IT IS THE WORK THAT

3536
02:25:11,965 --> 02:25:15,936
WE'RE JUST STARTING NOW IS ON

3537
02:25:15,936 --> 02:25:17,237
DEVELOPING EARLIER STAGE

3538
02:25:17,237 --> 02:25:18,405
OSTEOARTHRITIS CLASSIFICATION

3539
02:25:18,405 --> 02:25:19,873
CRITERIA BECAUSE WE'VE

3540
02:25:19,873 --> 02:25:22,476
RECOGNIZED THAT OUR STANDARD

3541
02:25:22,476 --> 02:25:23,243
INCLUSION CRITERIA OF GRADE 2

3542
02:25:23,243 --> 02:25:25,979
AND 3 IS TOO LATE IN THE PROCESS

3543
02:25:25,979 --> 02:25:30,484
FOR MANY OF THE PHARMACEUTICAL

3544
02:25:30,484 --> 02:25:30,818
TARGETS.

3545
02:25:30,818 --> 02:25:33,420
HOWEVER, WHO TO INCLUDE, IF

3546
02:25:33,420 --> 02:25:35,956
WE'RE NOT USING GRADE 2 AND 3,

3547
02:25:35,956 --> 02:25:37,691
IS AN UNANSWERED QUESTION.

3548
02:25:37,691 --> 02:25:39,226
SO AN AREA THAT WILL HELP

3549
02:25:39,226 --> 02:25:41,195
CLINICAL TRIALS IS ONCE WE

3550
02:25:41,195 --> 02:25:42,629
DEVELOP THOSE CRITERIA.

3551
02:25:42,629 --> 02:25:45,032
AND THEN THE OTHER IS THAT

3552
02:25:45,032 --> 02:25:46,934
OSTEOARTHRITIS IS NOT A

3553
02:25:46,934 --> 02:25:48,202
MONOLITHTIC ONE DISEASE.

3554
02:25:48,202 --> 02:25:50,070
THERE ARE MANY PATHWAYS THAT

3555
02:25:50,070 --> 02:25:51,305
CONTRIBUTE TO THIS END PHENOTYPE

3556
02:25:51,305 --> 02:25:53,474
OF WHAT WE SEE ON X-RAY.

3557
02:25:53,474 --> 02:25:54,908
AND SO A LOT MORE EFFORT NEEDS

3558
02:25:54,908 --> 02:25:58,312
TO BE DONE IN UNDERSTANDING

3559
02:25:58,312 --> 02:26:07,788
THESE PHENOTYPES SO, FOR

3560
02:26:07,788 --> 02:26:11,191
EXAMPLE, TEN TRIALS OF

3561
02:26:11,191 --> 02:26:13,127
COLTRACENE, FOUR OR FIVE HIGH

3562
02:26:13,127 --> 02:26:16,497
ENOUGH QUALITY TO DO A

3563
02:26:16,497 --> 02:26:16,830
META-ANALYSIS.

3564
02:26:16,830 --> 02:26:18,198
EFFECT SIZE IS .3.

3565
02:26:18,198 --> 02:26:21,602
AND BUT IT JUST MISSES

3566
02:26:21,602 --> 02:26:23,237
STATISTICAL SIGNIFICANCE.

3567
02:26:23,237 --> 02:26:25,105
SO THE POOLED EFFECT SIZE.

3568
02:26:25,105 --> 02:26:29,143
TO PUT THAT EFFECT SIZE IN

3569
02:26:29,143 --> 02:26:34,414
CONTEXT NON-STEROIDAL AL

3570
02:26:34,414 --> 02:26:36,316
ANTI-INFLAMMATORY DRUGS HAVE

3571
02:26:36,316 --> 02:26:41,288
EFFECT OF .3, WHEN POOLED IT'S

3572
02:26:41,288 --> 02:26:45,325
JUST BARELY MISSING STATISTICAL

3573
02:26:45,325 --> 02:26:46,226
SIGNIFICANCE.

3574
02:26:46,226 --> 02:26:48,996
YOU GET LOCODANE 2, BETWEEN 35

3575
02:26:48,996 --> 02:26:53,367
TO 100 PARTICIPANTS, 3 TO 6

3576
02:26:53,367 --> 02:26:54,468
MONTHS IN DURATION.

3577
02:26:54,468 --> 02:26:56,403
5500 PEOPLE OVER I THINK FIVE

3578
02:26:56,403 --> 02:26:58,939
YEARS OF FOLLOW-UP, THEY FINALLY

3579
02:26:58,939 --> 02:27:00,340
FOUND A STATISTICALLY

3580
02:27:00,340 --> 02:27:00,908
SIGNIFICANT SIGNAL.

3581
02:27:00,908 --> 02:27:03,544
I THINK THAT'S JUST ILLUSTRATING

3582
02:27:03,544 --> 02:27:05,612
THE PROBLEM THAT -- AND I THINK

3583
02:27:05,612 --> 02:27:07,781
MANY PROBLEMS AND TREATMENTS

3584
02:27:07,781 --> 02:27:08,782
HAVE UNFORTUNATELY BEEN

3585
02:27:08,782 --> 02:27:12,553
DISCARTED AT PHASE 2 LEVEL, IL-1

3586
02:27:12,553 --> 02:27:14,354
BETA SAMPLE SIZES OF BETWEEN 130

3587
02:27:14,354 --> 02:27:17,658
TO I THINK THE LARGEST WAS 300,

3588
02:27:17,658 --> 02:27:20,494
THE SAMPLE SIZE THAT HAD 300 GOT

3589
02:27:20,494 --> 02:27:26,400
A P OF .05 BUT WAS ABANDONED.

3590
02:27:26,400 --> 02:27:28,535
KANSAS, FOUR OR FIVE YEARS OF

3591
02:27:28,535 --> 02:27:30,103
FOLLOW-UP, YOU SEE THE SIGNAL.

3592
02:27:30,103 --> 02:27:32,739
>> CAN I ASK ABOUT YOUR
COMMENTS

3593
02:27:32,739 --> 02:27:35,042
ON HETEROGENEITY, YOU FOCUS ON

3594
02:27:35,042 --> 02:27:38,979
KNEE, BUT FROM JOINT TO JOINT,

3595
02:27:38,979 --> 02:27:42,282
OSTEOARTHRITIS THOUGHT TO HAVE

3596
02:27:42,282 --> 02:27:45,652
SIMILAR UPSTREAM INPUTS AND

3597
02:27:45,652 --> 02:27:47,087
THEREFORE ARE REMISSING

3598
02:27:47,087 --> 02:27:48,188
SOMETHING BY NOT RECOGNIZING

3599
02:27:48,188 --> 02:27:48,956
HETEROGENEITY ACROSS JOINTS OR

3600
02:27:48,956 --> 02:27:50,691
RIGHT NOW WE HAVE ENOUGH TO DO

3601
02:27:50,691 --> 02:27:53,193
JUST BY FOCUSING ON KNEE?

3602
02:27:53,193 --> 02:27:57,264
>> RIGHT, YEAH, SO, YES, I
THINK

3603
02:27:57,264 --> 02:27:59,132
WHEN SOMEONE HAS KNEE

3604
02:27:59,132 --> 02:28:00,434
OSTEOARTHRITIS THEY RARELY ONLY

3605
02:28:00,434 --> 02:28:02,436
HAVE KNEE OSTEOARTHRITIS.

3606
02:28:02,436 --> 02:28:03,937
THEY WILL TYPICALLY DEVELOP

3607
02:28:03,937 --> 02:28:05,138
OSTEOARTHRITIS ELSEWHERE.

3608
02:28:05,138 --> 02:28:07,241
AND THAT'S AN AREA OF ACTIVE

3609
02:28:07,241 --> 02:28:11,178
RESEARCH BECAUSE IT'S NOT REALLY

3610
02:28:11,178 --> 02:28:14,581
UNDERSTOOD IF O.A. ISOLATED, THE

3611
02:28:14,581 --> 02:28:20,587
KNEE OR HIP, IF THAT PHENOTYPE

3612
02:28:20,587 --> 02:28:21,788
IS DIFFERENT AND MECHANISMS THAT

3613
02:28:21,788 --> 02:28:24,524
MIGHT BE DIFFERENT ARE NOT

3614
02:28:24,524 --> 02:28:24,825
UNDERSTOOD.

3615
02:28:24,825 --> 02:28:25,893
AND WHILE I THINK THE

3616
02:28:25,893 --> 02:28:26,927
OSTEOARTHRITIS COMMUNITY DOES

3617
02:28:26,927 --> 02:28:31,098
WANT TO TACKLE HIP AND HAND,

3618
02:28:31,098 --> 02:28:32,799
THERE'S -- YOU NEED A WIN

3619
02:28:32,799 --> 02:28:34,902
SOMEWHERE, THE NEED IS THE MOST

3620
02:28:34,902 --> 02:28:36,003
STUDIES TO DATE.

3621
02:28:36,003 --> 02:28:38,405
I'M ALSO WORKING WITH A HAND

3622
02:28:38,405 --> 02:28:40,407
O.A. COHORT IN NORWAY, WHERE

3623
02:28:40,407 --> 02:28:42,042
WE'RE FINDING ALMOST EXACTLY THE

3624
02:28:42,042 --> 02:28:43,911
SAME FINDINGS FOR PAIN

3625
02:28:43,911 --> 02:28:45,112
SENSITIZATION MEASURES IN HAND

3626
02:28:45,112 --> 02:28:48,382
OSTEOARTHRITIS, AT LEAST FROM A

3627
02:28:48,382 --> 02:28:50,017
PAIN MECHANISM PERSPECTIVE IT'S

3628
02:28:50,017 --> 02:28:53,654
MANY OF THE SAME THINGS.

3629
02:28:53,654 --> 02:28:56,456
AND SO THE NICE THING WITH THESE

3630
02:28:56,456 --> 02:28:57,457
COLLABORATIONS, WHAT WE DO IN

3631
02:28:57,457 --> 02:29:01,295
ONE CO- COHORT WE TRY TO

3632
02:29:01,295 --> 02:29:02,996
REPLICATE IN ANOTHER.

3633
02:29:02,996 --> 02:29:04,531
VERY GOOD.

3634
02:29:04,531 --> 02:29:10,370
THANK YOU SO MUCH, DR. NEOGI.

3635
02:29:10,370 --> 02:29:11,204
>> THANK YOU.

3636
02:29:11,204 --> 02:29:12,572
>> NOW WE'RE GOING TO TAKE
A

3637
02:29:12,572 --> 02:29:16,176
LUNCH BREAK BEFORE OUR NEXT

3638
02:29:16,176 --> 02:29:18,312
SPEAKER, DR. TARA SCHWETZ,

3639
02:29:18,312 --> 02:29:21,448
COMING AT 12:15 SO WE'LL HAVE A

3640
02:29:21,448 --> 02:29:21,782
BREAK.

3641
02:29:21,782 --> 02:29:24,918
IF EVERYONE COULD COME BACK BY

3642
02:29:24,918 --> 02:29:26,153
AROUND 12:10 THAT WOULD BE GREAT

3643
02:29:26,153 --> 02:29:28,021
AND WE'LL BE READY FOR OUR FINAL

3644
02:29:28,021 --> 02:29:28,355
SPEAKER.

3645
02:29:28,355 --> 02:29:34,261
WE'LL DO A LUNCH BREAK, AGAIN

3646
02:29:34,261 --> 02:29:35,333
THE CAFETERIA IS OPEN UPSTAIRS,
AND WE'LL BE BACK BY 12:10.

3647
02:29:38,671 --> 02:29:41,440
>> THANK YOU, WELCOME BACK
FROM

3648
02:29:41,440 --> 02:29:41,641
LUNCH.

3649
02:29:41,641 --> 02:29:47,346
IT'S A PLEASURE TO INTRODUCE

3650
02:29:47,346 --> 02:29:50,283
TARA SCHWETZ, UNDERGRADUATE FROM

3651
02:29:50,283 --> 02:29:51,284
FLORIDA STATE, BIOPHYSICS,

3652
02:29:51,284 --> 02:29:53,886
PERFECT PREPARATION FOR THE ROLE

3653
02:29:53,886 --> 02:30:01,027
SHE'S IN NOW, FROM UNIVERSITY OF

3654
02:30:01,027 --> 02:30:02,428
SOUTH FLORIDA, POSTDOCTORAL AT

3655
02:30:02,428 --> 02:30:03,996
VANDERBILT, NIH IN 2012.

3656
02:30:03,996 --> 02:30:06,933
SHE'S BEEN INVOLVED IN AN

3657
02:30:06,933 --> 02:30:08,634
EXTRAORDINARY NUMBER TRULY OF

3658
02:30:08,634 --> 02:30:10,336
LEADERSHIP POSITIONS ACROSS ALL

3659
02:30:10,336 --> 02:30:15,508
OF NIH, ACTING DIRECTOR OF 

3660
02:30:15,508 --> 02:30:16,576
NURSING INSTITUTE, ACTING

3661
02:30:16,576 --> 02:30:17,476
PRINCIPAL DEPUTY DIRECTOR FOR

3662
02:30:17,476 --> 02:30:19,745
ALL OF NIH, TOOK A YEAR OFF,

3663
02:30:19,745 --> 02:30:23,583
WORKING ON DETAIL FOR THE WHITE

3664
02:30:23,583 --> 02:30:24,884
HOUSE, PRINCIPAL ADVISER IN

3665
02:30:24,884 --> 02:30:25,985
FORMATION OF ARPA-H AND IT GOES

3666
02:30:25,985 --> 02:30:26,886
ON AND ON.

3667
02:30:26,886 --> 02:30:29,488
I'VE HAD THE GREAT PLEASURE OF

3668
02:30:29,488 --> 02:30:30,556
DEALING WITH HER, ADVANTAGE OF

3669
02:30:30,556 --> 02:30:32,458
HER LEADERSHIP IN A NUMBER OF

3670
02:30:32,458 --> 02:30:34,327
NIH-WIDE EFFORTS, SO I'M GLAD WE

3671
02:30:34,327 --> 02:30:35,628
CAN SHARE HER AND HER KNOWLEDGE

3672
02:30:35,628 --> 02:30:36,729
WITH ALL OF YOU.

3673
02:30:36,729 --> 02:30:42,134
SHE WILL BE TALKING ABOUT

3674
02:30:42,134 --> 02:30:43,769
DPCPSI, I WON'T EVEN TRY EXPLAIN

3675
02:30:43,769 --> 02:30:44,770
WHAT IT IS BECAUSE THAT'S WHAT

3676
02:30:44,770 --> 02:30:46,072
SHE WILL BE TELLING US ABOUT.

3677
02:30:46,072 --> 02:30:47,707
THANK YOU FOR BEING WITH US AND

3678
02:30:47,707 --> 02:30:50,910
WE LOOK FORWARD TO HEARING ABOUT

3679
02:30:50,910 --> 02:30:56,916
DPCPSI. 

3680
02:30:56,916 --> 02:30:57,516
>> THANKS, RICHARD.

3681
02:30:57,516 --> 02:30:58,818
I'VE HAD THE PLEASURE OF WORKING

3682
02:30:58,818 --> 02:31:00,953
WITH RICHARD ON A NUMBER OF

3683
02:31:00,953 --> 02:31:02,622
INITIATIVES OVER THE YEARS, SO

3684
02:31:02,622 --> 02:31:04,924
REALLY GLAD TO BE HERE AND I

3685
02:31:04,924 --> 02:31:06,993
RECOGNIZE THAT THIS IS NOT ONLY

3686
02:31:06,993 --> 02:31:08,527
POST LUNCH BUT THE LAST THING

3687
02:31:08,527 --> 02:31:11,364
THAT YOU HAVE BEFORE YOU ALL

3688
02:31:11,364 --> 02:31:14,200
HEAD OFF TO THE AIRPORT, SO I

3689
02:31:14,200 --> 02:31:16,636
WILL TRY TO BE THOROUGH BUT

3690
02:31:16,636 --> 02:31:19,038
BRIEF AS MUCH AS I CAN.

3691
02:31:19,038 --> 02:31:21,107
AS RICHARD SAID, I'M THE NIH

3692
02:31:21,107 --> 02:31:22,875
DEPUTY DIRECTOR FOR PROGRAM

3693
02:31:22,875 --> 02:31:23,910
COORDINATION, PLANNING, AND

3694
02:31:23,910 --> 02:31:24,944
STRATEGIC INITIATIVES.

3695
02:31:24,944 --> 02:31:29,649
AS PART OF THAT ROLE, I'M ALSO

3696
02:31:29,649 --> 02:31:31,617
THE DIRECTOR OF DPCPSI, WHICH

3697
02:31:31,617 --> 02:31:34,120
STANDS FOR DIVISION OF PROGRAM

3698
02:31:34,120 --> 02:31:34,687
COORDINATION PLANNING AND

3699
02:31:34,687 --> 02:31:35,254
STRATEGIC INITIATIVE.

3700
02:31:35,254 --> 02:31:39,592
SO A LITTLE BIT OF A MOUTHFUL.

3701
02:31:39,592 --> 02:31:41,160
I THOUGHT I WOULD GIVE AN

3702
02:31:41,160 --> 02:31:43,763
OVERVIEW OF SOME THINGS THAT

3703
02:31:43,763 --> 02:31:46,499
WE'RE WORKING ON AT DPCPSI AND

3704
02:31:46,499 --> 02:31:49,368
WHERE WE SIT ORGANIZATIONALLY

3705
02:31:49,368 --> 02:31:53,072
AND WHAT OUR FOCUS AND MISSION

3706
02:31:53,072 --> 02:31:53,606
AREAS ARE.

3707
02:31:53,606 --> 02:31:57,543
SO, YOU ALL KNOW THE STRUCTURE

3708
02:31:57,543 --> 02:32:04,116
OF NIH, OBVIOUSLY, NIA IS ONE OF

3709
02:32:04,116 --> 02:32:04,817
27 INSTITUTES AND CENTERS,

3710
02:32:04,817 --> 02:32:07,954
DPCPSI SITS IN THE OFFICE OF THE

3711
02:32:07,954 --> 02:32:09,488
DIRECTOR, THE HIGHLIGHTED BOX

3712
02:32:09,488 --> 02:32:10,122
HERE.

3713
02:32:10,122 --> 02:32:17,763
WITHIN DPCPSI, WE'RE ACTUALLY

3714
02:32:17,763 --> 02:32:19,966
COMPOSED OF 14 OFFICES, IN THE

3715
02:32:19,966 --> 02:32:22,068
PROCESS OF MOVING TO DIFFERENT

3716
02:32:22,068 --> 02:32:24,570
OFFICES TO DPCPSI, SO THOSE ARE

3717
02:32:24,570 --> 02:32:26,005
PROPOSALS IN THE GRAY BOXES YOU

3718
02:32:26,005 --> 02:32:27,740
SEE HERE.

3719
02:32:27,740 --> 02:32:29,575
WE ALSO COORDINATE ONE

3720
02:32:29,575 --> 02:32:30,576
ADDITIONAL PROGRAM.

3721
02:32:30,576 --> 02:32:32,778
SO ESSENTIALLY, WHAT WE DO IN

3722
02:32:32,778 --> 02:32:36,115
DPCPSI IS COORDINATE ALL OF THE

3723
02:32:36,115 --> 02:32:37,717
CROSS-CUTTING TOPICS FOR ALL OF

3724
02:32:37,717 --> 02:32:38,017
NIH.

3725
02:32:38,017 --> 02:32:41,120
SO THINGS THAT TOUCH ON MULTIPLE

3726
02:32:41,120 --> 02:32:44,056
OR EVERY SINGLE INSTITUTE AND

3727
02:32:44,056 --> 02:32:44,390
CENTER.

3728
02:32:44,390 --> 02:32:46,726
SO, I KIND OF LOOK AT OUR OFFICE

3729
02:32:46,726 --> 02:32:48,227
STRUCTURE IN A FEW WAYS.

3730
02:32:48,227 --> 02:32:50,963
WE'VE GOT A NUMBER OF

3731
02:32:50,963 --> 02:32:52,064
PROGRAMMATIC COORDINATION

3732
02:32:52,064 --> 02:32:52,398
OFFICES.

3733
02:32:52,398 --> 02:32:55,468
THINGS THAT HIT ON, AGAIN, THOSE

3734
02:32:55,468 --> 02:32:57,603
REALLY CROSS-CUTTING AREAS LIKE

3735
02:32:57,603 --> 02:32:58,537
OUR OFFICE OF DATA SCIENCE

3736
02:32:58,537 --> 02:33:00,673
STRATEGY, OFFICE OF RESEARCH ON

3737
02:33:00,673 --> 02:33:04,210
WOMEN'S HEALTH, OUR OFFICE OF

3738
02:33:04,210 --> 02:33:05,511
BEHAVIORAL AND SOCIAL SCIENCES,

3739
02:33:05,511 --> 02:33:06,846
TRIBAL HEALTH RESEARCH OFFICE,

3740
02:33:06,846 --> 02:33:08,781
EXAMPLES, AND I COULD GO ON

3741
02:33:08,781 --> 02:33:09,882
OBVIOUSLY, MANY MORE TIMES

3742
02:33:09,882 --> 02:33:12,952
BECAUSE THERE ARE 16 OFFICES.

3743
02:33:12,952 --> 02:33:14,920
BUT THOSE ARE EXAMPLES OF SORT

3744
02:33:14,920 --> 02:33:16,255
OF THE PROGRAMMATIC COORDINATION

3745
02:33:16,255 --> 02:33:16,922
OFFICES.

3746
02:33:16,922 --> 02:33:20,526
WE HAVE A FEW THAT ARE FOCUSED

3747
02:33:20,526 --> 02:33:23,062
ON PARTICULAR AREAS, SO THOSE

3748
02:33:23,062 --> 02:33:25,131
INCLUDE THINGS LIKE OUR OFFICE

3749
02:33:25,131 --> 02:33:26,665
OF RESEARCH INFRASTRUCTURE

3750
02:33:26,665 --> 02:33:30,503
PROGRAM THAT HELPS US SUPPORT

3751
02:33:30,503 --> 02:33:34,907
ANIMAL MODEL FACILITIES, AND 

3752
02:33:34,907 --> 02:33:37,943
SORT OF CONSTRUCTION AND

3753
02:33:37,943 --> 02:33:39,578
INFRASTRUCTURE PROGRAMS.

3754
02:33:39,578 --> 02:33:41,447
WE ALSO HAVE THE COMMON FUND

3755
02:33:41,447 --> 02:33:43,416
WITHIN DPCPSI, WITHIN OUR OFFICE

3756
02:33:43,416 --> 02:33:45,051
OF STRATEGIC COORDINATION.

3757
02:33:45,051 --> 02:33:46,685
AND THEN THE TWO PROPOSED TO

3758
02:33:46,685 --> 02:33:48,854
MOVE TO DPCPSI AND WE'RE IN THE

3759
02:33:48,854 --> 02:33:51,490
PROCESS OF DOING THAT, IT'S JUST

3760
02:33:51,490 --> 02:33:53,459
NOT FINAL YET, ARE THE "ALL OF

3761
02:33:53,459 --> 02:33:54,894
US" RESEARCH PROGRAM AND THE

3762
02:33:54,894 --> 02:33:56,328
ENVIRONMENTAL INFLUENCES ON

3763
02:33:56,328 --> 02:33:58,864
CHILD HEALTH OUTCOMES, ECHO

3764
02:33:58,864 --> 02:34:00,066
PROGRAM.

3765
02:34:00,066 --> 02:34:01,267
AND WE ALSO HAVE THE "INCLUDE"

3766
02:34:01,267 --> 02:34:02,668
PROGRAM, WHICH DOESN'T HAVE AN

3767
02:34:02,668 --> 02:34:03,769
OFFICE ASSOCIATED WITH IT BUT

3768
02:34:03,769 --> 02:34:10,676
IT'S AN EFFORT THAT RICHARD AND

3769
02:34:10,676 --> 02:34:12,311
I CO-CHAIR WITH DOCTORS DIANA

3770
02:34:12,311 --> 02:34:15,281
BIANCHI AND GARY GIBBONS.

3771
02:34:15,281 --> 02:34:16,916
WE HAVE ANOTHER BUCKET OF

3772
02:34:16,916 --> 02:34:21,720
OFFICES THAT ARE FOCUSED ON

3773
02:34:21,720 --> 02:34:23,255
DEVELOPING RESOURCES AND TOOLS

3774
02:34:23,255 --> 02:34:24,457
FOR NIH COMMUNITY, SO MOST OF

3775
02:34:24,457 --> 02:34:26,425
THAT IS SORT OF OUR

3776
02:34:26,425 --> 02:34:28,627
INTERNAL-FACING WORK THAT WE DO

3777
02:34:28,627 --> 02:34:29,061
ACROSS NIH.

3778
02:34:29,061 --> 02:34:32,031
BUT THINGS THAT HELP US BETTER

3779
02:34:32,031 --> 02:34:34,533
UNDERSTAND AND ASSESS OUR

3780
02:34:34,533 --> 02:34:36,302
PORTFOLIO, OUR OFFICE PORTFOLIO

3781
02:34:36,302 --> 02:34:38,938
ANALYSIS, AND OFFICES THAT HELP

3782
02:34:38,938 --> 02:34:42,074
US MONITOR AND TRACK OUR

3783
02:34:42,074 --> 02:34:42,842
PERFORMANCE METRICS, HELP

3784
02:34:42,842 --> 02:34:44,477
EVALUATE DIFFERENT PROGRAMS WE

3785
02:34:44,477 --> 02:34:47,246
DO. 

3786
02:34:47,246 --> 02:34:49,615
THAT'S OUR OFFICE OF EVALUATION

3787
02:34:49,615 --> 02:34:52,818
PERFORMANCE AND REPORTING.

3788
02:34:52,818 --> 02:34:56,422
IN A HIGHER LEVEL WAY WHAT DO WE

3789
02:34:56,422 --> 02:34:56,755
DO?

3790
02:34:56,755 --> 02:34:58,057
THE FIRST ITEM THAT YOU'RE

3791
02:34:58,057 --> 02:35:00,459
LOOKING AT ON YOUR LEFT IS

3792
02:35:00,459 --> 02:35:03,562
REALLY THE MAIN THING WE DO, BUT

3793
02:35:03,562 --> 02:35:05,698
THEY ARE ALL OF THE THINGS THAT

3794
02:35:05,698 --> 02:35:09,301
ARE KIND OF IN DPCPSI IN SUPPORT

3795
02:35:09,301 --> 02:35:11,170
OF TRYING TO ALIGN AND CATALYZE

3796
02:35:11,170 --> 02:35:11,770
SCIENCE.

3797
02:35:11,770 --> 02:35:13,906
WE DO THAT BROADLY AGAIN ACROSS

3798
02:35:13,906 --> 02:35:14,940
NIH.

3799
02:35:14,940 --> 02:35:16,876
WE DO THAT THROUGH RESOURCE

3800
02:35:16,876 --> 02:35:19,078
DEVELOPMENT AND FACILITATING

3801
02:35:19,078 --> 02:35:20,045
STRATEGIC COORDINATION ACROSS

3802
02:35:20,045 --> 02:35:20,913
THE BOARD.

3803
02:35:20,913 --> 02:35:22,781
SO, WHEN WE GET INTO THE NEXT

3804
02:35:22,781 --> 02:35:23,983
LEVEL DOWN, THE DETAILS OF HOW

3805
02:35:23,983 --> 02:35:27,153
WE DO THAT, YOU CAN SEE THAT AT

3806
02:35:27,153 --> 02:35:32,191
THE BOTTOM THROUGH SYNERGISTIC

3807
02:35:32,191 --> 02:35:32,958
COORDINATION BY BUILDING UP

3808
02:35:32,958 --> 02:35:34,593
PARTNERSHIPS IN KEY AREAS WE

3809
02:35:34,593 --> 02:35:35,461
CHARGED WITH ACROSS OUR

3810
02:35:35,461 --> 02:35:36,695
DIFFERENT OFFICES.

3811
02:35:36,695 --> 02:35:43,569
WE DO THAT THROUGH IDENTIFYING

3812
02:35:43,569 --> 02:35:44,136
AND CATALYZING RESEARCH

3813
02:35:44,136 --> 02:35:45,304
OPPORTUNITIES AND GAPS THAT WE

3814
02:35:45,304 --> 02:35:47,406
IDENTIFY AND SEE AND FOSTER

3815
02:35:47,406 --> 02:35:48,707
COLLABORATION TO BE ABLE TO

3816
02:35:48,707 --> 02:35:49,675
ADDRESS THOSE.

3817
02:35:49,675 --> 02:35:51,777
WE THINK ABOUT DEVELOPING NEW

3818
02:35:51,777 --> 02:35:53,746
METHODS TO ENABLE THE DIFFERENT

3819
02:35:53,746 --> 02:35:58,117
RESEARCH GOALS ACROSS THE BOARD.

3820
02:35:58,117 --> 02:35:59,618
THIS IS A NEW WAY OF DESCRIBING

3821
02:35:59,618 --> 02:36:01,620
KIND OF ONE OF THE THINGS WE DO,

3822
02:36:01,620 --> 02:36:04,557
A THING I THINK IS MOST

3823
02:36:04,557 --> 02:36:09,161
EXCITING, WE SERVE AS 

3824
02:36:09,161 --> 02:36:10,596
EXPERIMENTAL TEST BED FOR NIH

3825
02:36:10,596 --> 02:36:12,665
ACTIVITIES, THE PLACE THAT'S

3826
02:36:12,665 --> 02:36:14,300
FORWARD THINKING, THINKING ABOUT

3827
02:36:14,300 --> 02:36:18,137
HOW WE CAN DO OUR SCIENCE BETTER

3828
02:36:18,137 --> 02:36:18,671
AND DIFFERENTLY, MORE

3829
02:36:18,671 --> 02:36:20,206
EFFECTIVELY ACROSS THE BOARD AT

3830
02:36:20,206 --> 02:36:22,074
NIH, CARRIED OUT IN A SMALL

3831
02:36:22,074 --> 02:36:25,444
SCALE THING TO SEE HOW IT WORKS.

3832
02:36:25,444 --> 02:36:28,614
WE'VE PIONEERED IN A BIG WAY THE

3833
02:36:28,614 --> 02:36:31,150
USE OF OTHER TRANSACTION

3834
02:36:31,150 --> 02:36:33,118
AUTHORITIES TO FUND AWARDS, WE

3835
02:36:33,118 --> 02:36:36,288
ALSO MANAGE ALL OF THE CHALLENGE

3836
02:36:36,288 --> 02:36:40,793
PRIZES THAT COME THROUGH NIH.

3837
02:36:40,793 --> 02:36:40,993
OKAY.

3838
02:36:40,993 --> 02:36:42,928
SO, OUR VISION ACROSS DPCPSI, WE

3839
02:36:42,928 --> 02:36:45,364
CALL THIS OUR RECIPE FOR

3840
02:36:45,364 --> 02:36:46,365
SUCCESS, AND YOU'LL UNDERSTAND

3841
02:36:46,365 --> 02:36:48,334
WHY IN A SECOND.

3842
02:36:48,334 --> 02:36:51,403
BUT IT'S REALLY TO ADVANCE

3843
02:36:51,403 --> 02:36:53,272
BIOMEDICAL AND BEHAVIORAL

3844
02:36:53,272 --> 02:36:55,641
SCIENCE COORDINATING

3845
02:36:55,641 --> 02:36:56,742
CROSS-CUTTING INNOVATIVE

3846
02:36:56,742 --> 02:36:57,876
SOLUTIONS THAT FOSTER INSTITUTES

3847
02:36:57,876 --> 02:36:58,744
COLLABORATION AND HELP IMPROVE

3848
02:36:58,744 --> 02:37:00,379
THE HEALTH OF THE NATION.

3849
02:37:00,379 --> 02:37:03,849
THAT'S KIND OF AT THE END OF THE

3850
02:37:03,849 --> 02:37:06,185
DAY WHAT WE'RE STRIVING TO

3851
02:37:06,185 --> 02:37:06,919
ACHIEVE.

3852
02:37:06,919 --> 02:37:08,053
SO OUR VALUES, THESE ARE

3853
02:37:08,053 --> 02:37:09,355
PROPOSED VALUES, THIS IS

3854
02:37:09,355 --> 02:37:11,590
SOMETHING NEW FOR DPCPSI THAT

3855
02:37:11,590 --> 02:37:14,126
WE'RE STILL WORKING ON.

3856
02:37:14,126 --> 02:37:16,161
BUT THE TEAMS ACROSS THE

3857
02:37:16,161 --> 02:37:17,296
DIVISION ARE GOING THROUGH AND

3858
02:37:17,296 --> 02:37:18,664
REFINING THESE A LITTLE BIT MORE

3859
02:37:18,664 --> 02:37:20,099
SO THAT'S WHY WE SAY THEY ARE

3860
02:37:20,099 --> 02:37:22,601
PROPOSED BECAUSE WE WANT THEM TO

3861
02:37:22,601 --> 02:37:24,436
BE OUR COLLECTIVE VALUES ACROSS

3862
02:37:24,436 --> 02:37:26,772
THE WHOLE DIVISION AND NOT JUST

3863
02:37:26,772 --> 02:37:27,973
FROM LEADERSHIP DOWN OR FROM A

3864
02:37:27,973 --> 02:37:28,507
FEW KEY PLACES.

3865
02:37:28,507 --> 02:37:31,377
THIS IS WHERE YOU GET THE

3866
02:37:31,377 --> 02:37:33,145
RECIPE, YOU CAN SEE THAT THERE,

3867
02:37:33,145 --> 02:37:34,913
THINKING ABOUT HOW WE CAN

3868
02:37:34,913 --> 02:37:37,182
CONTINUE TO FOSTER AND BUILD

3869
02:37:37,182 --> 02:37:38,050
RESPECT AND CELEBRATING

3870
02:37:38,050 --> 02:37:40,252
DIVERSITY OF THE CONTRIBUTIONS

3871
02:37:40,252 --> 02:37:41,987
OF EVERYONE ON THE TEAM, AGAIN

3872
02:37:41,987 --> 02:37:43,188
COORDINATION IS A MAJOR

3873
02:37:43,188 --> 02:37:45,257
COMPONENT OF WHAT WE DO AT

3874
02:37:45,257 --> 02:37:45,491
DPCPSI.

3875
02:37:45,491 --> 02:37:48,227
WE'RE CALLING THAT OUT AS WELL

3876
02:37:48,227 --> 02:37:49,728
AS STIMULATING INNOVATION.

3877
02:37:49,728 --> 02:37:51,930
THINKING ABOUT, YOU KNOW, DOING

3878
02:37:51,930 --> 02:37:53,832
THOSE THINGS THROUGH

3879
02:37:53,832 --> 02:37:55,901
PARTNERSHIPS, AND HELPING TO DO

3880
02:37:55,901 --> 02:37:58,637
THAT IN A REALLY THOUGHTFUL WAY

3881
02:37:58,637 --> 02:37:59,738
WHERE WE'RE PRIORITIZING

3882
02:37:59,738 --> 02:38:01,040
EXCELLENCE BUT EXCELLENCE IN ALL

3883
02:38:01,040 --> 02:38:03,108
ASPECTS OF WHAT WE DO INCLUDING

3884
02:38:03,108 --> 02:38:06,512
BEING INCLUSIVE OF ALL

3885
02:38:06,512 --> 02:38:07,713
POPULATIONS.

3886
02:38:07,713 --> 02:38:07,913
OKAY.

3887
02:38:07,913 --> 02:38:10,215
SO, OUR GOALS IN ORDER TO BE

3888
02:38:10,215 --> 02:38:11,750
ABLE TO DO THAT INCLUDE THE

3889
02:38:11,750 --> 02:38:13,952
THREE THINGS YOU SEE HERE.

3890
02:38:13,952 --> 02:38:15,454
REALLY FOCUSING ON THE RESEARCH

3891
02:38:15,454 --> 02:38:17,523
ADVANCEMENT AND HOW WE CAN ALIGN

3892
02:38:17,523 --> 02:38:19,425
AND CATALYZE RESOURCES ACROSS

3893
02:38:19,425 --> 02:38:22,528
THE BOARD TO STIMULATE

3894
02:38:22,528 --> 02:38:23,228
TRANSFORMATIONAL SCIENCE.

3895
02:38:23,228 --> 02:38:26,532
WE  NEED TO HAVE A STRONG WORK

3896
02:38:26,532 --> 02:38:30,436
FORCE TO DO THAT, TO SUPPORT THE

3897
02:38:30,436 --> 02:38:32,304
WORKFORCE WITHIN OUR

3898
02:38:32,304 --> 02:38:33,739
ORGANIZATION EFFICIENTLY AND

3899
02:38:33,739 --> 02:38:35,274
EFFECTIVELY AND MAKE SURE WE'RE

3900
02:38:35,274 --> 02:38:38,811
MINIMIZING BURDEN ON THEM.

3901
02:38:38,811 --> 02:38:40,646
AND THEN ENGAGING EXTERNALLY,

3902
02:38:40,646 --> 02:38:42,915
WE'RE USING THIS WORD PRETTY

3903
02:38:42,915 --> 02:38:44,616
BROADLY IN TERMS OF EXTERNAL,

3904
02:38:44,616 --> 02:38:47,219
THAT'S BOTH ACROSS THE BOARD

3905
02:38:47,219 --> 02:38:49,521
WITHIN NIH AS WELL AS OTHER

3906
02:38:49,521 --> 02:38:51,590
FEDERAL AGENCIES, BUT ALSO WITH

3907
02:38:51,590 --> 02:38:54,693
THE COMMUNITY, WITH THE RESEARCH

3908
02:38:54,693 --> 02:38:55,327
COMMUNITY.

3909
02:38:55,327 --> 02:38:57,296
TO HELP PROMOTE AND ENHANCE WHAT

3910
02:38:57,296 --> 02:38:59,264
WE DO NOT ONLY AT DPCPSI BUT

3911
02:38:59,264 --> 02:39:01,233
ACROSS ALL OF NIH.

3912
02:39:01,233 --> 02:39:03,435
AGAIN, WHAT WE SUPPORT ACROSS

3913
02:39:03,435 --> 02:39:05,270
DPCPSI IS REALLY AGENCY WIDE.

3914
02:39:05,270 --> 02:39:07,206
SO, I JUST WANTED TO GIVE A FEW

3915
02:39:07,206 --> 02:39:08,907
EXAMPLES OF SOME OF THE SELECT

3916
02:39:08,907 --> 02:39:13,278
PROGRAMS THAT WE'RE WORKING ON,

3917
02:39:13,278 --> 02:39:13,946
SOME EXCITING THINGS COMING

3918
02:39:13,946 --> 02:39:17,483
THROUGH AS OF LATE. 

3919
02:39:17,483 --> 02:39:20,185
THE WHITE HOUSE RECENTLY

3920
02:39:20,185 --> 02:39:21,086
ESTABLISHED WOMEN'S HEALTH

3921
02:39:21,086 --> 02:39:21,820
RESEARCH INITIATIVE.

3922
02:39:21,820 --> 02:39:24,189
AND BACK IN MARCH THE PRESIDENT

3923
02:39:24,189 --> 02:39:26,859
SIGNED A NEW EXECUTIVE ORDER

3924
02:39:26,859 --> 02:39:30,796
THAT HELPED TO SPUR INNOVATION

3925
02:39:30,796 --> 02:39:32,231
AND UNLEASH TRANSFORMATIVE

3926
02:39:32,231 --> 02:39:34,199
INVESTMENT TO HELP CLOSE

3927
02:39:34,199 --> 02:39:34,833
RESEARCH GAPS AND IMPROVE

3928
02:39:34,833 --> 02:39:36,268
WOMEN'S HEALTH.

3929
02:39:36,268 --> 02:39:38,604
WHEN THEY PUT THIS OUT THEY

3930
02:39:38,604 --> 02:39:40,139
LAUNCHED 20 NEW ACTIONS

3931
02:39:40,139 --> 02:39:41,640
INCLUDING MANY BY NIH.

3932
02:39:41,640 --> 02:39:44,076
AND WE'RE SORT OF A LEADER IN

3933
02:39:44,076 --> 02:39:46,378
THIS EFFORT, AS YOU MIGHT

3934
02:39:46,378 --> 02:39:47,679
IMAGINE, JUST GIVEN THE TOPIC

3935
02:39:47,679 --> 02:39:51,417
AND SOME OF THE THINGS THAT WE

3936
02:39:51,417 --> 02:39:54,720
HAVE SO FAR DONE AND LAST WEEK

3937
02:39:54,720 --> 02:39:55,921
WAS NATIONAL WOMEN'S HEALTH

3938
02:39:55,921 --> 02:39:58,757
WEEK, WE HAD A LOT OF VARIOUS

3939
02:39:58,757 --> 02:40:01,794
ACTIVITIES GOING ON.

3940
02:40:01,794 --> 02:40:05,731
WE HAD THE PINN SYMPOSIUM, PUT

3941
02:40:05,731 --> 02:40:07,266
OUT RECORDS, BIENNIAL REPORT ON

3942
02:40:07,266 --> 02:40:08,801
STRATEGIC HEALTH AND NEW PLAN ON

3943
02:40:08,801 --> 02:40:10,235
WOMEN'S HEALTH, THERE WAS A LOT

3944
02:40:10,235 --> 02:40:11,437
GOING ON, AN EXCITING WEEK FOR

3945
02:40:11,437 --> 02:40:13,405
US LAST WEEK.

3946
02:40:13,405 --> 02:40:15,140
THINKING MORE SPECIFICALLY ABOUT

3947
02:40:15,140 --> 02:40:17,209
THE EXECUTIVE ORDER, WE PUT OUT

3948
02:40:17,209 --> 02:40:19,745
A NEW NIH-WIDE WOMEN'S HEALTH

3949
02:40:19,745 --> 02:40:20,946
RESEARCH NOSI, THAT HELPED TO

3950
02:40:20,946 --> 02:40:23,582
LINK ALL OF THE PARENT FUNDING

3951
02:40:23,582 --> 02:40:24,883
OPPORTUNITIES ACROSS NIH AND IT

3952
02:40:24,883 --> 02:40:26,418
WAS ALSO A GREAT OPPORTUNITY

3953
02:40:26,418 --> 02:40:29,655
WHERE ALL THE INSTITUTES AND

3954
02:40:29,655 --> 02:40:32,424
CENTERS INCLUDING NIA PUT

3955
02:40:32,424 --> 02:40:33,525
EMPHASIZE ANDS ECHO AND

3956
02:40:33,525 --> 02:40:34,393
HIGHLIGHT PRIORITIES IN WOMEN'S

3957
02:40:34,393 --> 02:40:35,394
HEALTH AND WHAT THEY ARE

3958
02:40:35,394 --> 02:40:36,595
INTERESTED IN SEEING COME

3959
02:40:36,595 --> 02:40:39,331
FORWARD THROUGH ALL THOSE PARENT

3960
02:40:39,331 --> 02:40:40,332
FUNDING OPPORTUNITY

3961
02:40:40,332 --> 02:40:40,666
ANNOUNCEMENTS.

3962
02:40:40,666 --> 02:40:44,903
WE ALSO LAUNCHED OUR FIRST EVER 

3963
02:40:44,903 --> 02:40:48,207
PATHWAYS TO PREVENTION SERIES ON

3964
02:40:48,207 --> 02:40:49,007
MENOPAUSE, MANAGING

3965
02:40:49,007 --> 02:40:51,176
MENOPAUSE-RELATED ISSUES KICKING

3966
02:40:51,176 --> 02:40:51,376
OFF.

3967
02:40:51,376 --> 02:40:54,646
WE WORKED WITH AHRQ AND ACROSS

3968
02:40:54,646 --> 02:40:57,850
INTERAGENCY TO DO THESE PATHWAYS

3969
02:40:57,850 --> 02:40:59,051
TO PREVENTIONS, ULTIMATELY AFTER

3970
02:40:59,051 --> 02:41:01,687
THE END OF A YEAR AND A

3971
02:41:01,687 --> 02:41:03,655
HALF-LONG PROCESS WE'LL HAVE A

3972
02:41:03,655 --> 02:41:07,359
REPORT THAT WE'LL PUT FORWARD

3973
02:41:07,359 --> 02:41:09,328
WITH RECOMMENDATIONS AND ACTION

3974
02:41:09,328 --> 02:41:11,296
PLAN FOR NEXT STEPS.

3975
02:41:11,296 --> 02:41:15,133
AND THEN THERE WAS A COMMITMENT

3976
02:41:15,133 --> 02:41:16,468
TO CONTINUING TO IMPROVE UPON

3977
02:41:16,468 --> 02:41:18,871
AND ACCELERATE WORK WE'RE DOING

3978
02:41:18,871 --> 02:41:20,439
IN THE SBIR/STTR SPACE WHEN IT

3979
02:41:20,439 --> 02:41:23,909
COMES TO WOMEN'S HEALTH.

3980
02:41:23,909 --> 02:41:25,978
AND NIH-WIDE COMMITTED TO

3981
02:41:25,978 --> 02:41:28,947
INCREASING THAT BY 50% OVER THE

3982
02:41:28,947 --> 02:41:30,582
NEXT SEVERAL YEARS.

3983
02:41:30,582 --> 02:41:31,483
ALL RIGHT.

3984
02:41:31,483 --> 02:41:32,985
TOTALLY SWITCHING GEARS, I'M

3985
02:41:32,985 --> 02:41:34,520
GOING TO HIGHLIGHT A FEW THINGS

3986
02:41:34,520 --> 02:41:36,488
THAT WE'RE WORKING ON HERE.

3987
02:41:36,488 --> 02:41:38,457
BUT I WANT TO HIGHLIGHT THE NEXT

3988
02:41:38,457 --> 02:41:42,628
TWO SLIDES, TWO OF THE THINGS

3989
02:41:42,628 --> 02:41:44,429
THAT MONICA, DR. BERTAGNOLLI IS

3990
02:41:44,429 --> 02:41:46,465
EXCITED ABOUT, VERY MUCH HER

3991
02:41:46,465 --> 02:41:47,432
PRIORITIES AS SHE STEPPED INTO

3992
02:41:47,432 --> 02:41:49,535
HER NEW ROLE AS NIH DIRECTOR.

3993
02:41:49,535 --> 02:41:52,671
THE FIRST ONE IS THINKING ABOUT

3994
02:41:52,671 --> 02:41:54,540
HOW WE CAN HELP TO ADDRESS THIS

3995
02:41:54,540 --> 02:41:56,208
PROBLEM THAT'S ON HERE THAT WE

3996
02:41:56,208 --> 02:41:58,176
ALL CAN APPRECIATE, WHICH IS THE

3997
02:41:58,176 --> 02:41:59,811
DECLINING HEALTH OF THE U.S.

3998
02:41:59,811 --> 02:42:02,314
POPULATION AND IN PARTICULAR

3999
02:42:02,314 --> 02:42:04,850
THAT DECLINE BEING STEEPEST

4000
02:42:04,850 --> 02:42:06,251
AMONGST THOSE UNDERSERVED AND

4001
02:42:06,251 --> 02:42:06,752
UNDERREPRESENTED.

4002
02:42:06,752 --> 02:42:09,087
BECAUSE THOSE PEOPLE TEND TO

4003
02:42:09,087 --> 02:42:10,856
HAVE THE GREATEST, YOU KNOW,

4004
02:42:10,856 --> 02:42:12,257
HEALTH DISPARITIES, SO WE WANT

4005
02:42:12,257 --> 02:42:13,792
TO MAKE SURE THE WORK WE'RE

4006
02:42:13,792 --> 02:42:16,194
DOING AT NIH IS BEING ACCESSIBLE

4007
02:42:16,194 --> 02:42:17,296
TO EVERYONE.

4008
02:42:17,296 --> 02:42:19,164
AND THAT WE'RE GIVING EVERYONE

4009
02:42:19,164 --> 02:42:21,466
ACCESS TO THE OPPORTUNITY TO

4010
02:42:21,466 --> 02:42:23,435
PARTICIPATE IN CLINICAL RESEARCH

4011
02:42:23,435 --> 02:42:24,436
AND CLINICAL TRIALS.

4012
02:42:24,436 --> 02:42:26,171
SO, WE WANT TO MAKE SURE WE'RE

4013
02:42:26,171 --> 02:42:27,673
GOING TO BE ADDRESSING THE

4014
02:42:27,673 --> 02:42:28,807
CONCERNS OF THE COMMUNITY.

4015
02:42:28,807 --> 02:42:32,077
SO THIS IS SOMETHING THAT WE'RE

4016
02:42:32,077 --> 02:42:33,378
BUILDING OUT, A CLINICAL

4017
02:42:33,378 --> 02:42:36,248
RESEARCH NETWORK IN PRIMARY CARE

4018
02:42:36,248 --> 02:42:38,317
SETTINGS, TO REALLY HELP BUILD

4019
02:42:38,317 --> 02:42:40,018
UP THIS NETWORK THAT WILL BE

4020
02:42:40,018 --> 02:42:40,819
DISEASE AGNOSTIC.

4021
02:42:40,819 --> 02:42:42,821
IT WILL BE REALLY FOCUSING ON

4022
02:42:42,821 --> 02:42:45,857
IMPROVING HEALTH AND NOT ON

4023
02:42:45,857 --> 02:42:47,526
NECESSARILY TACKLING A

4024
02:42:47,526 --> 02:42:48,927
PARTICULAR DISEASE.

4025
02:42:48,927 --> 02:42:51,663
AGAIN, TRYING TO ADDRESS THE

4026
02:42:51,663 --> 02:42:53,432
QUESTIONS AND THE CONCERNS THE

4027
02:42:53,432 --> 02:42:54,399
COMMUNITIES THEMSELVES HAVE.

4028
02:42:54,399 --> 02:42:56,168
WE'LL CREATE A SUITE OF OPTIONS

4029
02:42:56,168 --> 02:42:58,904
SO THE SITES THAT ARE INVOLVED

4030
02:42:58,904 --> 02:43:00,539
CAN CHOOSE TO PARTICIPATE IN

4031
02:43:00,539 --> 02:43:02,107
PARTICULAR STUDIES, OR NOT, AND

4032
02:43:02,107 --> 02:43:05,377
FOCUS IN ON THOSE ONES THAT BEST

4033
02:43:05,377 --> 02:43:06,912
MEET NEEDS OF THEIR COMMUNITY.

4034
02:43:06,912 --> 02:43:10,616
WE'RE ALSO THINKING ABOUT HOW WE

4035
02:43:10,616 --> 02:43:11,283
CAN INTEGRATE INNOVATIVE

4036
02:43:11,283 --> 02:43:13,251
RESEARCH DESIGNS INTO THIS AND

4037
02:43:13,251 --> 02:43:17,289
HELP TO THINK THAT NEW WAYS THAT

4038
02:43:17,289 --> 02:43:21,793
WE CAN IMPROVE CLINICAL RESEARCH

4039
02:43:21,793 --> 02:43:23,862
AND CLINICAL CARE IN REAL WORLD

4040
02:43:23,862 --> 02:43:24,830
SETTINGS.

4041
02:43:24,830 --> 02:43:27,065
CREATING FOUNDATION FOR

4042
02:43:27,065 --> 02:43:28,266
SUSTAINED AND SUSTAINABLE

4043
02:43:28,266 --> 02:43:29,568
ENGAGEMENT WITH COMMUNITIES.

4044
02:43:29,568 --> 02:43:31,003
SO, WE WANT TO MAKE SURE WE'RE

4045
02:43:31,003 --> 02:43:32,871
NOT GOING TO POP IN, POP OUT.

4046
02:43:32,871 --> 02:43:34,506
ONE THING WE HEAR OVER AND OVER

4047
02:43:34,506 --> 02:43:35,807
AGAIN FROM COMMUNITIES IS THAT

4048
02:43:35,807 --> 02:43:38,443
WE NEED TO MAKE SURE THAT WE CAN

4049
02:43:38,443 --> 02:43:40,679
BUILD RELATIONSHIPS AND CONTINUE

4050
02:43:40,679 --> 02:43:41,847
TO BUILD TRUST AND SO WANT TO

4051
02:43:41,847 --> 02:43:44,149
MAKE SURE THIS EFFORT IS GOING

4052
02:43:44,149 --> 02:43:46,284
TO BE DURABLE, THAT IT ISN'T

4053
02:43:46,284 --> 02:43:47,719
GOING COME IN AND DISAPPEAR WHEN

4054
02:43:47,719 --> 02:43:51,056
THE STUDY ENDS, FOR INSTANCE.

4055
02:43:51,056 --> 02:43:53,125
IT WILL BE A LONG-TERM EFFORT

4056
02:43:53,125 --> 02:43:55,193
AND COMMITMENT THAT WE'RE

4057
02:43:55,193 --> 02:43:56,728
PUTTING FORWARD.

4058
02:43:56,728 --> 02:43:58,930
SO, WE'RE STARTING SMALL, OR AS

4059
02:43:58,930 --> 02:44:00,966
WE LIKE TO SAY, NARROW.

4060
02:44:00,966 --> 02:44:04,369
AND MAKING SURE THAT WE CAN DO

4061
02:44:04,369 --> 02:44:05,237
THIS EFFICIENTLY AND

4062
02:44:05,237 --> 02:44:06,538
EFFECTIVELY, AND PROVE SUCCESS

4063
02:44:06,538 --> 02:44:09,074
IN OUR FIRST FISCAL YEAR.

4064
02:44:09,074 --> 02:44:13,478
SO WE ALREADY HAVE A ROA ON THE

4065
02:44:13,478 --> 02:44:15,113
STREET, APPLICATIONS ARE DUE

4066
02:44:15,113 --> 02:44:18,717
JOAN 14, TO FUND A FEW SITES, A

4067
02:44:18,717 --> 02:44:20,452
HANDFUL OF SITES THIS YEAR.

4068
02:44:20,452 --> 02:44:21,553
FISCAL YEAR 2024.

4069
02:44:21,553 --> 02:44:23,722
SO THAT'S WHY THE DOLLAR AMOUNT

4070
02:44:23,722 --> 02:44:26,258
IS STILL FAIRLY SMALL.

4071
02:44:26,258 --> 02:44:29,861
THIS IS KIND OF THE BUILDING

4072
02:44:29,861 --> 02:44:32,397
YEAR WITH THIS EFFORT, AND THEN

4073
02:44:32,397 --> 02:44:34,466
WE'LL CONTINUE TO EXPAND IN 25

4074
02:44:34,466 --> 02:44:38,970
AND HOPEFULLY RAMP IT UP IN THE

4075
02:44:38,970 --> 02:44:39,938
COMING FISCAL YEARS.

4076
02:44:39,938 --> 02:44:40,505
ALL RIGHT.

4077
02:44:40,505 --> 02:44:43,341
AND THEN ONE OF THE OTHER THINGS

4078
02:44:43,341 --> 02:44:45,410
THAT I THINK IS REALLY SALIENT

4079
02:44:45,410 --> 02:44:48,146
AND DOES RELATE IN SOME WAYS TO

4080
02:44:48,146 --> 02:44:49,915
THE PRIMARY CARE NET BECAUSE WE

4081
02:44:49,915 --> 02:44:52,851
HAVE ALL THESE DATA THAT ARE IN

4082
02:44:52,851 --> 02:44:53,852
CLINICAL CARE SETTINGS AND WE

4083
02:44:53,852 --> 02:44:59,191
NEED TO PULL THOSE OUT AND ALLOW

4084
02:44:59,191 --> 02:45:02,160
ACCESS TO THAT VERY EFFICIENTLY.

4085
02:45:02,160 --> 02:45:02,461
AND EASILY.

4086
02:45:02,461 --> 02:45:04,463
AND SO ONE OF THE THINGS THAT

4087
02:45:04,463 --> 02:45:07,833
WE'RE WORKING ON IS TO HELP TO

4088
02:45:07,833 --> 02:45:10,268
PROVIDE AN EASIER MECHANISM FOR

4089
02:45:10,268 --> 02:45:12,003
THAT TO BE AVAILABLE.

4090
02:45:12,003 --> 02:45:13,739
AND WE'RE WORKING ACROSS ALL OF

4091
02:45:13,739 --> 02:45:16,575
HHS ON THIS, SO WORKING WITH

4092
02:45:16,575 --> 02:45:20,445
OTHER FEDERAL AGENCIES TO HELP

4093
02:45:20,445 --> 02:45:21,847
FACILITATE THIS EFFORT WHERE

4094
02:45:21,847 --> 02:45:26,318
WE'LL HELP TO INCREASE DATA

4095
02:45:26,318 --> 02:45:27,753
QUALITY AND ACCESSES DATA,

4096
02:45:27,753 --> 02:45:29,721
HOPEFULLY ELIMINATE COSTLY DATA

4097
02:45:29,721 --> 02:45:30,822
FORMATTING AND COLLECTION

4098
02:45:30,822 --> 02:45:32,357
REDUNDANCIES THAT WE'VE HEARD A

4099
02:45:32,357 --> 02:45:34,526
LOT ABOUT, JUST MAKE IT EASIER

4100
02:45:34,526 --> 02:45:35,627
TO ACCESS.

4101
02:45:35,627 --> 02:45:38,930
AND THERE ARE RIGHT NOW, WE'RE

4102
02:45:38,930 --> 02:45:41,733
SORT OF USING THE MOTTO SELECT

4103
02:45:41,733 --> 02:45:43,301
ONCE, USE NUMEROUS TIMES, WITHIN

4104
02:45:43,301 --> 02:45:44,603
THE DATA OPPORTUNITY SOMETHING

4105
02:45:44,603 --> 02:45:46,371
THEY SAY, TRYING TO FIGURE OUT A

4106
02:45:46,371 --> 02:45:49,307
WAY WE CAN LEVERAGE ONE PATHWAY

4107
02:45:49,307 --> 02:45:52,277
TO COLLECT DATA AND HAVE IT BE

4108
02:45:52,277 --> 02:45:54,913
ACCESSIBLE TO MANY PEOPLE FOR

4109
02:45:54,913 --> 02:45:56,214
MANY USES.

4110
02:45:56,214 --> 02:45:59,618
AND ELIMINATE SOME REDUNDANCIES.

4111
02:45:59,618 --> 02:46:01,586
YOU CAN SEE HERE ON THE RIGHT

4112
02:46:01,586 --> 02:46:03,688
SIDE OF THE SCREEN SOME OF THE

4113
02:46:03,688 --> 02:46:07,793
THINGS WE'RE THINKING ABOUT IN

4114
02:46:07,793 --> 02:46:08,727
TERMS OF LAUNCHING

4115
02:46:08,727 --> 02:46:10,028
PROOF-OF-CONCEPT EFFORTS TO

4116
02:46:10,028 --> 02:46:11,096
DEMONSTRATE SUCCESS IN THIS

4117
02:46:11,096 --> 02:46:12,864
SPACE AND WE'RE WORKING WITH CDC

4118
02:46:12,864 --> 02:46:16,368
AND FDA ON A FEW THINGS TO TRY

4119
02:46:16,368 --> 02:46:19,171
TO HELP US MODERNIZE DATA

4120
02:46:19,171 --> 02:46:23,308
COLLECTION FOR ONE OF THE NCI

4121
02:46:23,308 --> 02:46:24,276
PROGRAMS, THE SEER REGISTRY,

4122
02:46:24,276 --> 02:46:28,747
THINKING ABOUT HOW WE DO THIS

4123
02:46:28,747 --> 02:46:29,948
FORK POST-MARKET DATA

4124
02:46:29,948 --> 02:46:31,583
COLLECTION, IN PARTICULAR THE

4125
02:46:31,583 --> 02:46:32,918
MODEL THAT WE'RE KIND OF

4126
02:46:32,918 --> 02:46:37,055
NARROWING IN ON IS USING GLP-1

4127
02:46:37,055 --> 02:46:37,823
RIGHT NOW.

4128
02:46:37,823 --> 02:46:41,660
SO HOT AND SO BIG.

4129
02:46:41,660 --> 02:46:44,396
AS SOMEONE WHO STUDIED GLP-1 IN

4130
02:46:44,396 --> 02:46:45,564
MY POSTDOC, SIDE NOTE, YOU CAN

4131
02:46:45,564 --> 02:46:47,465
HAVE THAT TALK AT THE DINNER

4132
02:46:47,465 --> 02:46:50,202
TABLE WITH GRANDMA AND THEY

4133
02:46:50,202 --> 02:46:51,203
HEARD OF GLP-1.

4134
02:46:51,203 --> 02:46:53,605
WE'RE EXCITED ABOUT THIS EFFORT,

4135
02:46:53,605 --> 02:46:57,209
TRYING TO STREAMLINE DATA ACCESS

4136
02:46:57,209 --> 02:46:57,742
AND ACCESSIBILITY TO

4137
02:46:57,742 --> 02:46:58,043
RESEARCHERS.

4138
02:46:58,043 --> 02:46:59,077
AND THEN ONE OF THE OTHER THINGS

4139
02:46:59,077 --> 02:47:02,080
I WANT TO MAKE SURE TO HIGHLIGHT

4140
02:47:02,080 --> 02:47:04,583
IS THE INCLUDE PROJECT,

4141
02:47:04,583 --> 02:47:06,551
SOMETHING THAT WAS MENTIONED

4142
02:47:06,551 --> 02:47:08,987
EARLY THAT RICHARD AND I

4143
02:47:08,987 --> 02:47:10,388
CO-CHAIR WITH DIANA BIANCHI AND

4144
02:47:10,388 --> 02:47:12,157
GARY GIBBONS.

4145
02:47:12,157 --> 02:47:14,359
IT'S FOCUSED ON HELPING TO

4146
02:47:14,359 --> 02:47:15,560
INVESTIGATE CONDITIONS THAT

4147
02:47:15,560 --> 02:47:17,762
AFFECT INDIVIDUALS WITH DOWN

4148
02:47:17,762 --> 02:47:18,029
SYNDROME.

4149
02:47:18,029 --> 02:47:20,298
AND OF COURSE THERE'S LOTS OF

4150
02:47:20,298 --> 02:47:23,735
APPLICABILITY TO THAT WITH THE

4151
02:47:23,735 --> 02:47:25,570
GENERAL POPULATION.

4152
02:47:25,570 --> 02:47:26,872
THIS PROGRAM LAUNCHED IN 2018,

4153
02:47:26,872 --> 02:47:30,141
AND SO FAR HAS FUNDED OVER 330

4154
02:47:30,141 --> 02:47:30,809
AWARDS.

4155
02:47:30,809 --> 02:47:33,178
AND WE'RE REALLY TRYING TO BUILD

4156
02:47:33,178 --> 02:47:38,250
UP THE COHORT THAT WE HAVE

4157
02:47:38,250 --> 02:47:42,420
WITHIN THIS PROGRAM TO INCREASE

4158
02:47:42,420 --> 02:47:44,089
THE FOCUS ON BEING ABLE TO

4159
02:47:44,089 --> 02:47:46,157
ANSWER SOME OF THOSE CLINICAL

4160
02:47:46,157 --> 02:47:50,862
QUESTIONS AND BEING ABLE TO

4161
02:47:50,862 --> 02:47:52,297
UNDERSTAND, YOU KNOW, NOT JUST

4162
02:47:52,297 --> 02:47:54,366
-- AND ADDRESS NOT JUST ISSUES

4163
02:47:54,366 --> 02:47:55,567
THAT IMPACT THOSE WITH DOWN

4164
02:47:55,567 --> 02:47:57,002
SYNDROME BUT TO UNDERSTAND WHY

4165
02:47:57,002 --> 02:48:03,775
THERE ARE SORT OF PREVENTIVE 

4166
02:48:03,775 --> 02:48:05,410
ASPECTS OF THE DISEASE,

4167
02:48:05,410 --> 02:48:07,612
DEVELOPING CERTAIN CANCERS, LOTS

4168
02:48:07,612 --> 02:48:08,213
OF APPLICABILITY BEYOND JUST

4169
02:48:08,213 --> 02:48:09,948
DOWN SYNDROME BUT IT'S REALLY A

4170
02:48:09,948 --> 02:48:11,449
GREAT PROGRAM THAT I THINK WE'RE

4171
02:48:11,449 --> 02:48:13,285
REALLY PROUD OF SOME OF THE WORK

4172
02:48:13,285 --> 02:48:15,287
THAT IT'S BEEN DOING OVER THE

4173
02:48:15,287 --> 02:48:17,889
LAST SEVERAL YEARS.

4174
02:48:17,889 --> 02:48:18,123
OKAY.

4175
02:48:18,123 --> 02:48:20,625
AND THEN I WANT TO GIVE A COUPLE

4176
02:48:20,625 --> 02:48:22,494
LITTLE EXAMPLES OF SOME OTHER

4177
02:48:22,494 --> 02:48:25,363
THINGS THAT WE'RE WORKING ON

4178
02:48:25,363 --> 02:48:26,564
WITHIN DPCPSI.

4179
02:48:26,564 --> 02:48:28,600
WE ARE -- WE'VE HEARD THAT

4180
02:48:28,600 --> 02:48:30,802
THERE'S BEEN A LOT OF INTEREST

4181
02:48:30,802 --> 02:48:33,271
ACROSS THE AGENCY AND HELPING TO

4182
02:48:33,271 --> 02:48:37,609
FIGURE OUT WAYS TO WORK WITH

4183
02:48:37,609 --> 02:48:40,779
TRIBAL COMMUNITIES, AND RESPECT

4184
02:48:40,779 --> 02:48:43,048
THEIR LAWS AND REGULATIONS AND

4185
02:48:43,048 --> 02:48:43,848
IN PARTICULAR THE SOVEREIGNTY

4186
02:48:43,848 --> 02:48:45,450
THAT THEY HAVE.

4187
02:48:45,450 --> 02:48:47,686
SO WE'RE DEVELOPING AN

4188
02:48:47,686 --> 02:48:48,653
INDIGENOUS DATA SOVEREIGNTY

4189
02:48:48,653 --> 02:48:51,489
POLICY THAT WILL HELP US MANAGE

4190
02:48:51,489 --> 02:48:52,590
THIS ACROSS THE BOARD.

4191
02:48:52,590 --> 02:48:55,226
ONE OF THE OTHER THINGS THAT

4192
02:48:55,226 --> 02:48:57,495
WE'RE WORKING ON IS ADDRESSING

4193
02:48:57,495 --> 02:48:59,764
SOME CONCERNS FROM THE COMMUNITY

4194
02:48:59,764 --> 02:49:01,533
WRIT LARGE ABOUT NON-HUMAN

4195
02:49:01,533 --> 02:49:03,935
PRIMATE, AND SO WE'RE WORKING

4196
02:49:03,935 --> 02:49:05,503
RIGHT NOW ON AN ANALYSIS STUDY

4197
02:49:05,503 --> 02:49:08,773
WE HOPE WILL BE OUT PRETTY SOON.

4198
02:49:08,773 --> 02:49:11,609
THAT HELPS US KIND OF JUST -- IT

4199
02:49:11,609 --> 02:49:16,214
SETS THE  STAGE FOR WHERE WE ARE

4200
02:49:16,214 --> 02:49:20,251
ACROSS THE BOARD FOR MEDICAL

4201
02:49:20,251 --> 02:49:21,686
RESEARCH COMMUNITY UTILIZING NHP

4202
02:49:21,686 --> 02:49:24,723
MODELS, THINKING ABOUT WAYS THIS

4203
02:49:24,723 --> 02:49:25,724
WILL INFORM STRATEGIC MANAGEMENT

4204
02:49:25,724 --> 02:49:27,692
PLANNING THAT WE'RE DOING ACROSS

4205
02:49:27,692 --> 02:49:28,727
NIH.

4206
02:49:28,727 --> 02:49:32,931
AND THEN FINALLY NEW APPROACH

4207
02:49:32,931 --> 02:49:35,233
METHODS, WE'RE LEADING

4208
02:49:35,233 --> 02:49:36,334
IMPLEMENTATION PLAN FOR THE

4209
02:49:36,334 --> 02:49:39,371
DIRECTORS WORKING GROUP THAT PUT

4210
02:49:39,371 --> 02:49:40,372
FORWARD GREAT AND SPECIFIC

4211
02:49:40,372 --> 02:49:44,542
RECOMMENDATIONS FOR HOW WE CAN

4212
02:49:44,542 --> 02:49:48,546
THINK ABOUT USING IN SILICO AND

4213
02:49:48,546 --> 02:49:50,749
CHEMICO, AND IN VITRO TECHNIQUES

4214
02:49:50,749 --> 02:49:54,819
TO BE ABLE TO EITHER VALIDATE

4215
02:49:54,819 --> 02:49:56,688
OR, YOU KNOW, BE COMPLEMENTARY

4216
02:49:56,688 --> 02:49:58,523
TO THE EXISTING ANIMAL MODELS

4217
02:49:58,523 --> 02:49:59,824
THAT WE HAVE.

4218
02:49:59,824 --> 02:50:01,726
AND WITHIN THE COMMON FUND WE'VE

4219
02:50:01,726 --> 02:50:03,695
ACTUALLY LAUNCHED A PROGRAM

4220
02:50:03,695 --> 02:50:05,430
CALLED COMPLEMENTARY, THAT'S

4221
02:50:05,430 --> 02:50:06,865
TRYING TO PUSH FORWARD THIS AREA

4222
02:50:06,865 --> 02:50:07,599
OF SCIENCE.

4223
02:50:07,599 --> 02:50:11,236
SO EXCITED TO SEE THAT BECAUSE 

4224
02:50:11,236 --> 02:50:12,704
THAT'S STILL VERY NASCENT BUT

4225
02:50:12,704 --> 02:50:13,772
EXCITED TO SEE THE WORK THAT'S

4226
02:50:13,772 --> 02:50:14,973
GOING TO COME OUT OF THAT

4227
02:50:14,973 --> 02:50:17,342
PROGRAM AND MANY OTHER PROGRAMS

4228
02:50:17,342 --> 02:50:19,544
ACROSS NIH ALSO WORKING ON THIS.

4229
02:50:19,544 --> 02:50:21,713
AND MY VERY LAST SLIDE, I HATE

4230
02:50:21,713 --> 02:50:25,183
TO END ON THE CHALLENGES, BUT

4231
02:50:25,183 --> 02:50:26,418
I'LL FRAME THIS AS A CHALLENGE

4232
02:50:26,418 --> 02:50:28,186
IS US A AN OPPORTUNITY.

4233
02:50:28,186 --> 02:50:30,622
WE'RE ALWAYS THINKING ABOUT WAYS

4234
02:50:30,622 --> 02:50:32,791
IN WHICH WE CAN STREAMLINE AND I

4235
02:50:32,791 --> 02:50:35,193
THINK SOME OF THE THINGS THAT

4236
02:50:35,193 --> 02:50:36,761
WE'RE THINKING ABOUT IN TERMS OF

4237
02:50:36,761 --> 02:50:39,798
THE BUDGET CUT WE HAVE HAD FOR

4238
02:50:39,798 --> 02:50:40,665
FISCAL YEAR 24, ARE GREAT

4239
02:50:40,665 --> 02:50:42,333
OPPORTUNITIES FOR US TO TAKE

4240
02:50:42,333 --> 02:50:44,602
ANOTHER LOOK AT WHAT WE'RE

4241
02:50:44,602 --> 02:50:44,803
DOING.

4242
02:50:44,803 --> 02:50:47,906
BUT OUR "ALL OF US" RESEARCH

4243
02:50:47,906 --> 02:50:49,441
PROGRAM RECEIVES A 34% CUT,

4244
02:50:49,441 --> 02:50:52,143
COMMON FUND TOOK ABOUT A 7% CUT

4245
02:50:52,143 --> 02:50:53,011
FOR $50 MILLION.

4246
02:50:53,011 --> 02:50:56,548
THIS IS JUST SOMETHING THAT 

4247
02:50:56,548 --> 02:50:58,083
AGAIN WE'RE NAVIGATING THIS YEAR

4248
02:50:58,083 --> 02:51:01,352
AND WE'RE ALSO COUPLING THAT

4249
02:51:01,352 --> 02:51:03,321
WITH A TIME OF GREAT TRANSITION

4250
02:51:03,321 --> 02:51:06,724
WITHIN THE DIVISION BUT ALSO

4251
02:51:06,724 --> 02:51:08,693
AGAIN A GREAT OPPORTUNITY IN THE

4252
02:51:08,693 --> 02:51:09,761
LAST YEAR, YEAR-AND-A-HALF,

4253
02:51:09,761 --> 02:51:11,529
WE'VE HAD FIVE NEW OFFICE

4254
02:51:11,529 --> 02:51:13,731
DIRECTORS COME ON BOARD, AND WE

4255
02:51:13,731 --> 02:51:14,399
CURRENTLY HAVE TWO VACANCIES

4256
02:51:14,399 --> 02:51:16,901
THAT WE'RE IN THE VARIOUS STAGES

4257
02:51:16,901 --> 02:51:19,671
OF THE SEARCH PROCESS TO BE ABLE

4258
02:51:19,671 --> 02:51:20,205
TO FILL.

4259
02:51:20,205 --> 02:51:23,141
AND SO THAT COUPLED WITH THE TWO

4260
02:51:23,141 --> 02:51:25,043
NEW OFFICES AND ONE NEW PROGRAM

4261
02:51:25,043 --> 02:51:28,980
THAT JOINED DPCPSI EXCITED TO

4262
02:51:28,980 --> 02:51:30,115
THINK ABOUT THE NEXT PHASE OF

4263
02:51:30,115 --> 02:51:33,785
THE WORK THAT WE'RE DOING AND

4264
02:51:33,785 --> 02:51:35,120
OPPORTUNITY AGAIN TO RETHINK AND

4265
02:51:35,120 --> 02:51:36,654
REFRESH AND GET FEEDBACK FROM

4266
02:51:36,654 --> 02:51:38,289
EVERYONE ON WHERE WE SHOULD

4267
02:51:38,289 --> 02:51:40,158
FOCUS SOME OF OUR EFFORTS AND

4268
02:51:40,158 --> 02:51:42,127
ATTENTION AND HOW WE CAN

4269
02:51:42,127 --> 02:51:44,529
STRENGTHEN WHAT WE'RE DOING.

4270
02:51:44,529 --> 02:51:46,865
WITH THAT, I WILL MAYBE OPEN UP

4271
02:51:46,865 --> 02:51:50,034
FOR QUESTIONS, OR TURN IT BACK

4272
02:51:50,034 --> 02:51:53,171
TO RICHARD TO FACILITATE.

4273
02:51:53,171 --> 02:51:54,606
>> I JUST WANT TO THANK
YOU FOR

4274
02:51:54,606 --> 02:51:57,475
DESCRIBING WHAT I THINK YOU CAN

4275
02:51:57,475 --> 02:51:59,878
ALL SEE IS A HUGE, SOME MIGHT

4276
02:51:59,878 --> 02:52:01,412
SAY VAST AND EXTREMELY RELEVANT,

4277
02:52:01,412 --> 02:52:04,015
PART OF NIH THAT AFFECTS ALL OF

4278
02:52:04,015 --> 02:52:04,249
US.

4279
02:52:04,249 --> 02:52:07,152
SHARING THAT, WE'LL OPEN THAT TO

4280
02:52:07,152 --> 02:52:08,520
QUESTIONS, COMMENTS, PEOPLE

4281
02:52:08,520 --> 02:52:16,528
MIGHT HAVE FROM THE COUNCIL.

4282
02:52:16,528 --> 02:52:17,162
YES?

4283
02:52:17,162 --> 02:52:19,697
>> I'M REALLY EXCITED.

4284
02:52:19,697 --> 02:52:24,602
>> SPEAK IN THE
MICROPHONE.

4285
02:52:24,602 --> 02:52:29,440
>> SORRY. 

4286
02:52:29,440 --> 02:52:32,710
CAN YOU TALK ABOUT THE

4287
02:52:32,710 --> 02:52:35,146
INDIGENOUS DATA SOVEREIGNTY

4288
02:52:35,146 --> 02:52:38,416
POLICY, STATE LINE, WHAT'S THE

4289
02:52:38,416 --> 02:52:38,917
ADVANTAGE.

4290
02:52:38,917 --> 02:52:39,584
>> MAYBE INTRODUCE
YOURSELF TOO

4291
02:52:39,584 --> 02:52:42,153
A LITTLE BIT OF YOUR BACKGROUND

4292
02:52:42,153 --> 02:52:42,520
BRIEFLY.

4293
02:52:42,520 --> 02:52:53,031
IN THIS CASE THE PARTICULARS.

4294
02:52:55,600 --> 02:52:57,368
>> CHAIR OF IRB FOR
(INAUDIBLE)

4295
02:52:57,368 --> 02:52:59,204
NATION, WORKED WITH THEM FOR

4296
02:52:59,204 --> 02:53:00,972
ALMOST 30 YEARS.

4297
02:53:00,972 --> 02:53:01,639
SO YES.

4298
02:53:01,639 --> 02:53:04,676
I STARTED WHEN I WAS 10 YEARS

4299
02:53:04,676 --> 02:53:04,842
OLD.

4300
02:53:04,842 --> 02:53:05,543
[LAUGHTER]

4301
02:53:05,543 --> 02:53:08,746
>> I WAS GOING TO SAY 5,
SO

4302
02:53:08,746 --> 02:53:09,414
YEAH, OKAY.

4303
02:53:09,414 --> 02:53:11,716
NO, THAT'S A GREAT QUESTION.

4304
02:53:11,716 --> 02:53:13,318
BECAUSE THIS IS SOMETHING -- SO

4305
02:53:13,318 --> 02:53:14,052
OUR TRIBAL HEALTH RESEARCH

4306
02:53:14,052 --> 02:53:17,388
OFFICE IS ONE OF OUR NEWER

4307
02:53:17,388 --> 02:53:18,923
OFFICES WITHIN DPCPSI, AND THAT

4308
02:53:18,923 --> 02:53:22,093
IS ALSO ONE OF THE OFFICES THAT

4309
02:53:22,093 --> 02:53:23,728
JUST HIRED A NEW OFFICE DIRECTOR

4310
02:53:23,728 --> 02:53:25,597
WITHIN THE LAST YEAR OR SO.

4311
02:53:25,597 --> 02:53:29,067
SHE STARTED I THINK LAST APRIL.

4312
02:53:29,067 --> 02:53:31,603
SO SHE IS ON BOARD DOING

4313
02:53:31,603 --> 02:53:34,439
LISTENING SESSIONS TRYING TO

4314
02:53:34,439 --> 02:53:35,640
UNDERSTAND FROM DIFFERENT

4315
02:53:35,640 --> 02:53:38,943
COMMUNITIES BOTH WITHIN NIH AND

4316
02:53:38,943 --> 02:53:40,245
WITHIN TRIBAL COMMUNITIES TO

4317
02:53:40,245 --> 02:53:41,980
FIGURE OUT KIND OF WHERE SOME OF

4318
02:53:41,980 --> 02:53:43,848
THE CHALLENGES ARE AND WHAT

4319
02:53:43,848 --> 02:53:47,018
KEEPS COMING UP IS HOW TO

4320
02:53:47,018 --> 02:53:49,654
NAVIGATE AND MANAGE TRIBAL DATA.

4321
02:53:49,654 --> 02:53:52,290
AND ESPECIALLY WHEN YOU THINK

4322
02:53:52,290 --> 02:53:53,891
ABOUT SOVEREIGNTY OF OWNERSHIP,

4323
02:53:53,891 --> 02:53:55,893
OF THOSE DATA, BY THE TRIBES BUT

4324
02:53:55,893 --> 02:53:57,095
ALSO OF THE INDIVIDUALS AND THEN

4325
02:53:57,095 --> 02:53:58,730
I KNOW IT GETS EVEN MORE

4326
02:53:58,730 --> 02:54:00,999
COMPLICATED WHEN WE TALK ABOUT

4327
02:54:00,999 --> 02:54:02,734
URBAN INDIANS AND WHEN DATA IS

4328
02:54:02,734 --> 02:54:04,202
NOT COLLECTED ON THE

4329
02:54:04,202 --> 02:54:04,502
RESERVATION.

4330
02:54:04,502 --> 02:54:06,904
SO THERE'S A LOT OF ISSUES THAT

4331
02:54:06,904 --> 02:54:08,906
ARE GOING INTO THE CONSIDERATION

4332
02:54:08,906 --> 02:54:10,775
OF TRYING TO DEVELOP A POLICY

4333
02:54:10,775 --> 02:54:14,245
FOR HOW WE ACROSS THE BOARD AT

4334
02:54:14,245 --> 02:54:17,081
NIH CAN, YOU KNOW, ADDRESS THAT

4335
02:54:17,081 --> 02:54:20,051
IN A UNIFORM WAY SO WITH EVERY

4336
02:54:20,051 --> 02:54:22,120
PROGRAM WE CREATE WE DON'T HAVE

4337
02:54:22,120 --> 02:54:23,588
TO DO A CONSULTATION FOR HOW

4338
02:54:23,588 --> 02:54:24,756
WE'RE SETTING SOMETHING UP.

4339
02:54:24,756 --> 02:54:27,825
WE CAN THINK ABOUT WAYS TO

4340
02:54:27,825 --> 02:54:29,327
STREAMLINE THE PROCESS AND

4341
02:54:29,327 --> 02:54:30,361
IMPROVE ACROSS THE BOARD WHAT

4342
02:54:30,361 --> 02:54:31,329
WE'RE DOING.

4343
02:54:31,329 --> 02:54:33,431
BUT ALSO MAKING SURE THAT WE'RE

4344
02:54:33,431 --> 02:54:35,600
CONSULTING WITH IT AND ENGAGING

4345
02:54:35,600 --> 02:54:43,841
WITH TRIBAL NATIONS AS RELEVANT.

4346
02:54:43,841 --> 02:54:46,878
>> I'VE SHARED THIS WITH
FOLKS

4347
02:54:46,878 --> 02:54:47,245
IN OTHER FORUM.

4348
02:54:47,245 --> 02:54:50,081
CHEROKEE NATION IS THE ONLY 

4349
02:54:50,081 --> 02:54:52,150
TRIBE IN THE NATION, A SEER

4350
02:54:52,150 --> 02:54:54,018
REGISTRY FUNDED BY NCI.

4351
02:54:54,018 --> 02:54:57,588
WE HAVE BEEN CONTRIBUTING OUR

4352
02:54:57,588 --> 02:55:01,259
CANCER DATA SINCE 1997.

4353
02:55:01,259 --> 02:55:05,196
I WAS THE FIRST P.I. ON THE

4354
02:55:05,196 --> 02:55:05,630
PROJECT.

4355
02:55:05,630 --> 02:55:07,932
AND THE MODEL THAT I PERSONALLY

4356
02:55:07,932 --> 02:55:11,669
LIKE IS THAT OUR DATA GOES TO

4357
02:55:11,669 --> 02:55:15,707
NCI AND SITS ON A DATA ISLAND.

4358
02:55:15,707 --> 02:55:17,241
JUST CHEROKEE DATA.

4359
02:55:17,241 --> 02:55:19,577
WE CONTROL AND HAVE OWNERSHIP OF

4360
02:55:19,577 --> 02:55:21,112
ACCESS TO DATA.

4361
02:55:21,112 --> 02:55:23,748
SO WHEN A RESEARCHER APPROACHES

4362
02:55:23,748 --> 02:55:27,919
US AND THERE'S A MUTUAL INTEREST

4363
02:55:27,919 --> 02:55:29,554
IN ALLOWING ACCESS TO RESEARCH

4364
02:55:29,554 --> 02:55:32,390
BECAUSE THEY HAVE SOMETHING

4365
02:55:32,390 --> 02:55:34,359
REALLY VALUABLE TO OFFER, WE

4366
02:55:34,359 --> 02:55:35,626
SIGN OFF AND THEY GET ACCESS TO

4367
02:55:35,626 --> 02:55:36,094
THE MATERIAL.

4368
02:55:36,094 --> 02:55:40,164
I DON'T KNOW IF THAT'S SOMETHING

4369
02:55:40,164 --> 02:55:46,637
THAT'S A MODEL YOU CAN USE AT

4370
02:55:46,637 --> 02:55:49,941
THE NATIONAL LEVEL, BUT IN A --

4371
02:55:49,941 --> 02:55:53,244
THAT HAS WORKED SO FAR SO THE

4372
02:55:53,244 --> 02:55:54,846
OWNERSHIP RESTS WITH THE

4373
02:55:54,846 --> 02:55:57,181
CHEROKEE NATION.

4374
02:55:57,181 --> 02:55:58,249
>> WITH THE TRIBE.

4375
02:55:58,249 --> 02:55:59,484
THAT'S GREAT.

4376
02:55:59,484 --> 02:56:02,920
THAT'S A MODEL I THINK THAT'S

4377
02:56:02,920 --> 02:56:10,862
BEEN I THINK UTILIZED FOR OTHER

4378
02:56:10,862 --> 02:56:12,397
PROGRAMS AS WELL.

4379
02:56:12,397 --> 02:56:13,464
>> OTHER QUESTIONS?

4380
02:56:13,464 --> 02:56:13,931
SANJAY?

4381
02:56:13,931 --> 02:56:14,665
>> THANK YOU.

4382
02:56:14,665 --> 02:56:15,099
GREAT PRESENTATION.

4383
02:56:15,099 --> 02:56:15,967
THANK YOU SO MUCH.

4384
02:56:15,967 --> 02:56:17,001
REALLY APPRECIATE THE

4385
02:56:17,001 --> 02:56:17,735
INFORMATION.

4386
02:56:17,735 --> 02:56:19,670
I THINK THE NEW INITIATIVE YOU

4387
02:56:19,670 --> 02:56:20,905
TALKED ABOUT DOING CLINICAL

4388
02:56:20,905 --> 02:56:24,609
RESEARCH AND PRIMARY CARE

4389
02:56:24,609 --> 02:56:25,810
SETTINGS IS REALLY NEEDED IN

4390
02:56:25,810 --> 02:56:26,477
MEDICAL FIELD.

4391
02:56:26,477 --> 02:56:28,880
WASN'T TO KNOW FROM YOU, THE

4392
02:56:28,880 --> 02:56:33,184
REAL WORLD DATA THAT YOU'RE

4393
02:56:33,184 --> 02:56:35,353
ATTEMPTING TO COLLECT

4394
02:56:35,353 --> 02:56:37,021
ELECTRONIC HEALTH RECORD BASED

4395
02:56:37,021 --> 02:56:41,092
DATA, CLAIMS DATA AND OTHER DATA

4396
02:56:41,092 --> 02:56:43,060
ALSO LINKED WITH THAT.

4397
02:56:43,060 --> 02:56:47,532
WOULD THE DATA COLLECTION MOVING

4398
02:56:47,532 --> 02:56:50,368
FORWARD, COULD THERE BE

4399
02:56:50,368 --> 02:56:51,903
DISEASE-SPECIFIC DATA

4400
02:56:51,903 --> 02:56:52,203
COLLECTION?

4401
02:56:52,203 --> 02:56:55,072
I KNOW SEERs IS FOR CANCER,

4402
02:56:55,072 --> 02:56:56,874
COULD THERE BE SOMETHING FOR

4403
02:56:56,874 --> 02:56:57,742
DEMENTIA, CARDIOVASCULAR

4404
02:56:57,742 --> 02:56:58,910
DISEASE, OR GENERAL DATA

4405
02:56:58,910 --> 02:57:00,111
COLLECTION AS RELATED TO HEALTH

4406
02:57:00,111 --> 02:57:03,181
CARE UTILIZATION AND SOME CARE

4407
02:57:03,181 --> 02:57:03,581
QUALITY OUTCOMES?

4408
02:57:03,581 --> 02:57:05,783
>> YEAH, SO LET ME ANSWER
FROM

4409
02:57:05,783 --> 02:57:06,918
TWO PERSPECTIVES BECAUSE SOME OF

4410
02:57:06,918 --> 02:57:09,086
THE DATA WORK THAT WE'RE DOING

4411
02:57:09,086 --> 02:57:11,255
IS A DISTRICT PROGRAM FROM THE

4412
02:57:11,255 --> 02:57:12,924
PRIMARY CARE NETWORK.

4413
02:57:12,924 --> 02:57:14,459
WE SEE THEM CONVERGING BECAUSE

4414
02:57:14,459 --> 02:57:16,527
THE DATA WE'RE GENERATING FROM

4415
02:57:16,527 --> 02:57:17,728
THE PRIMARY CARE NETWORK IS

4416
02:57:17,728 --> 02:57:20,565
GOING TO BE DATA THAT IS

4417
02:57:20,565 --> 02:57:22,533
RELEVANT TO OUR DATA INITIATIVE.

4418
02:57:22,533 --> 02:57:25,736
THOUGH WE'LL HAVE THAT

4419
02:57:25,736 --> 02:57:28,806
INTERSECTION, THESE ARE BOTH

4420
02:57:28,806 --> 02:57:30,341
VERY NASCENT PROGRAMS.

4421
02:57:30,341 --> 02:57:32,076
LET ME ECHO THAT.

4422
02:57:32,076 --> 02:57:34,712
NO, I THINK ABSOLUTELY YOU HIT

4423
02:57:34,712 --> 02:57:37,782
ON KIND OF THAT EXACT IDEA FOR

4424
02:57:37,782 --> 02:57:39,851
THE PRIMARY CARE NETWORK AND

4425
02:57:39,851 --> 02:57:42,920
THAT WHAT WE WANT TO DO IS HAVE

4426
02:57:42,920 --> 02:57:44,689
THE COMMUNITY BE ABLE TO HAVE A

4427
02:57:44,689 --> 02:57:47,859
SUITE OF OPTIONS, ABLE TO

4428
02:57:47,859 --> 02:57:49,727
PARTICIPATE IN CERTAIN TRIALS OR

4429
02:57:49,727 --> 02:57:51,996
RESEARCH STUDIES, THAT THEY THEN

4430
02:57:51,996 --> 02:57:53,097
ARE ABLE TO SELECT BASED ON WHAT

4431
02:57:53,097 --> 02:57:55,299
THEY THINK THEY CAN DO IN THEIR

4432
02:57:55,299 --> 02:57:56,634
COMMUNITY, BASED ON WHAT THEY

4433
02:57:56,634 --> 02:57:57,502
ARE HEARING ARE NEEDED,

4434
02:57:57,502 --> 02:57:59,737
QUESTIONS TO ANSWER WITHIN THEIR

4435
02:57:59,737 --> 02:58:00,004
COMMUNITY.

4436
02:58:00,004 --> 02:58:02,640
THOSE COULD BE SPECIFIC

4437
02:58:02,640 --> 02:58:03,708
QUESTIONS AROUND ALZHEIMER'S

4438
02:58:03,708 --> 02:58:06,244
DISEASE, OR, YOU KNOW, CANCER

4439
02:58:06,244 --> 02:58:08,746
OR, YOU KNOW, ANY NUMBER OF

4440
02:58:08,746 --> 02:58:14,452
DISEASES OR CONDITIONS, WHEN WE

4441
02:58:14,452 --> 02:58:15,219
SAY DISEASE AGNOSTIC,

4442
02:58:15,219 --> 02:58:16,187
CROSS-CUTTING ACROSS MISSION

4443
02:58:16,187 --> 02:58:17,722
AREAS OF THE INSTITUTES AND

4444
02:58:17,722 --> 02:58:19,490
CENTERS, NOT NECESSARILY FOCUSED

4445
02:58:19,490 --> 02:58:25,696
ON ONE OR TWO OR A NUMBER OF

4446
02:58:25,696 --> 02:58:26,797
DIFFERENT DISEASE AREAS.

4447
02:58:26,797 --> 02:58:29,333
>> YOU PLAN TO CREATE A
NATIONAL

4448
02:58:29,333 --> 02:58:30,201
NETWORK OF SITES?

4449
02:58:30,201 --> 02:58:31,302
>> YEAH, EVENTUALLY.

4450
02:58:31,302 --> 02:58:33,371
THAT'S THE ULTIMATE GOAL.

4451
02:58:33,371 --> 02:58:34,639
WE'RE GOING TO SMART SMALL BUT

4452
02:58:34,639 --> 02:58:35,706
YES, THE IDEA WOULD BE

4453
02:58:35,706 --> 02:58:37,074
EVENTUALLY WE WOULD BE ABLE TO

4454
02:58:37,074 --> 02:58:39,076
EXPAND THIS OUT SO WE'RE HITTING

4455
02:58:39,076 --> 02:58:39,343
NATIONAL.

4456
02:58:39,343 --> 02:58:42,914
I WILL SAY ONE OF THINGS I

4457
02:58:42,914 --> 02:58:43,548
DIDN'T NECESSARILY EMPHASIZE BUT

4458
02:58:43,548 --> 02:58:50,922
SHOULD HAVE IN THE PRESENTATION 

4459
02:58:50,922 --> 02:58:52,290
WE'RE FOCUSING ESPECIALLY AT

4460
02:58:52,290 --> 02:58:53,758
FIRST ON RURAL POPULATION,

4461
02:58:53,758 --> 02:58:55,226
COMMUNITIES WHO REALLY NEED

4462
02:58:55,226 --> 02:58:55,927
ACCESS TO THESE STUDIES THE MOST

4463
02:58:55,927 --> 02:58:59,163
WE THINK.

4464
02:58:59,163 --> 02:59:01,699
>> AND I ASSUME THE FINAL
THING

4465
02:59:01,699 --> 02:59:03,768
THERE WILL BE MONITORING OF DATA

4466
02:59:03,768 --> 02:59:05,102
COLLECTION AT THE SITES DONE

4467
02:59:05,102 --> 02:59:07,605
CENTRALLY BY NIH.

4468
02:59:07,605 --> 02:59:09,373
>> YEAH, WE'RE LEVERAGING
AT

4469
02:59:09,373 --> 02:59:13,311
LEAST AGAIN TO START, WE'RE

4470
02:59:13,311 --> 02:59:15,613
LEVERAGING EXISTING NETWORKS AT

4471
02:59:15,613 --> 02:59:16,213
NIH.

4472
02:59:16,213 --> 02:59:19,116
SO NIGMS FUNDS ARE IDEA STATES,

4473
02:59:19,116 --> 02:59:20,084
CLINICAL AND TRANSLATIONAL

4474
02:59:20,084 --> 02:59:22,920
RESEARCH NETWORKS, WE HAVE THE

4475
02:59:22,920 --> 02:59:24,088
CTSAs, CLINICAL AND

4476
02:59:24,088 --> 02:59:25,556
TRANSLATIONAL SCIENCE AWARDS OUT

4477
02:59:25,556 --> 02:59:27,525
OF NCATS, AND THEN ONE OF THE

4478
02:59:27,525 --> 02:59:28,492
OTHER ELEMENTS THAT WE'RE

4479
02:59:28,492 --> 02:59:32,163
FOCUSING YOU ON IS PARTNERING

4480
02:59:32,163 --> 02:59:34,432
WITH PCORI, PCORnet, AND

4481
02:59:34,432 --> 02:59:36,500
REALLY KIND OF LEVERAGING THAT

4482
02:59:36,500 --> 02:59:38,803
INFRASTRUCTURE THAT ALREADY

4483
02:59:38,803 --> 02:59:41,439
EXISTS AND THE COMMITMENTS THAT

4484
02:59:41,439 --> 02:59:43,207
WE ALREADY HAVE IN THOSE

4485
02:59:43,207 --> 02:59:45,476
DIFFERENT AREAS, AND BEING ABLE

4486
02:59:45,476 --> 02:59:48,646
TO THEN KIND OF -- I DON'T WANT

4487
02:59:48,646 --> 02:59:51,749
TO SAY SUPPLEMENT, THAT IMPLIES

4488
02:59:51,749 --> 02:59:52,617
AN APPROACH FOR FUNDING, BUT

4489
02:59:52,617 --> 02:59:54,819
IT'S A WAY TO ADD ON AND

4490
02:59:54,819 --> 02:59:56,454
LEVERAGE THE WORK WE ALREADY

4491
02:59:56,454 --> 02:59:57,355
HAVE ONGOING IN THOSE AREAS.

4492
02:59:57,355 --> 03:00:01,192
MANY OF THOSE PROGRAMS HAVE BEEN

4493
03:00:01,192 --> 03:00:02,960
HELPING TO BUILD UP THE EHR

4494
03:00:02,960 --> 03:00:06,430
INFRASTRUCTURE  IN A LOT OF

4495
03:00:06,430 --> 03:00:09,400
THOSE EFFORTS.

4496
03:00:09,400 --> 03:00:11,202
>> BEFORE WE -- ONE
QUESTION

4497
03:00:11,202 --> 03:00:13,004
FROM THE CHAT, I'D LIKE TO ASK

4498
03:00:13,004 --> 03:00:17,375
FIRST AND WE'LL GO TO YOU.

4499
03:00:17,375 --> 03:00:19,677
THE QUESTION IS, OLDER PEOPLE

4500
03:00:19,677 --> 03:00:21,979
ARE ESPECIALLY VULNERABLE TO

4501
03:00:21,979 --> 03:00:25,583
EFFECTS OF CLIMATE CHANGE, DOES

4502
03:00:25,583 --> 03:00:26,917
DPCPSI ALSO STRATEGIZE ABOUT

4503
03:00:26,917 --> 03:00:29,420
CLIMATE CHANGE, BOTH RESEARCH ON

4504
03:00:29,420 --> 03:00:31,389
IT AND ALSO HOW RESEARCH

4505
03:00:31,389 --> 03:00:34,892
PROCESSES MIGHT BE PREPARED FOR

4506
03:00:34,892 --> 03:00:36,327
DISRUPTIONS TO RESEARCH STUDIES

4507
03:00:36,327 --> 03:00:38,763
AND CLINICAL TRIALS, SIMILAR TO

4508
03:00:38,763 --> 03:00:40,931
PREPARING FOR THE NEXT PANDEMIC

4509
03:00:40,931 --> 03:00:43,234
NIH RESEARCHERS COULD EVEN USE

4510
03:00:43,234 --> 03:00:44,568
THOSE DISRUPTIONS AS

4511
03:00:44,568 --> 03:00:46,871
OPPORTUNITIES TO LEARN ABOUT

4512
03:00:46,871 --> 03:00:48,105
RESILIENCE AND VULNERABILITY.

4513
03:00:48,105 --> 03:00:49,607
>> YEAH, NO, I THINK
THAT'S A

4514
03:00:49,607 --> 03:00:50,374
GREAT QUESTION.

4515
03:00:50,374 --> 03:00:52,343
SO ONE OF OUR PROGRAMS WE HAVE

4516
03:00:52,343 --> 03:00:54,512
RUN OUT OF THE COMMON FUND,

4517
03:00:54,512 --> 03:00:59,984
AGAIN STILL A FAIRLY NEW STUDY,

4518
03:00:59,984 --> 03:01:04,255
CALLED COMPASS. 

4519
03:01:04,255 --> 03:01:06,657
I'M BAD ABOUT REMEMBERING

4520
03:01:06,657 --> 03:01:07,224
ACRONYMS, A COMMUNITY-BASED

4521
03:01:07,224 --> 03:01:08,859
PROGRAM TO HELP THINK ABOUT

4522
03:01:08,859 --> 03:01:10,161
STRUCTURAL APPROACHES TO HOW WE

4523
03:01:10,161 --> 03:01:11,896
SUPPORT THE WORK THAT WE DO HERE

4524
03:01:11,896 --> 03:01:15,066
AT NIH AND ADDRESS SOME

4525
03:01:15,066 --> 03:01:17,368
HEALTH-RELATED QUESTIONS.

4526
03:01:17,368 --> 03:01:19,270
AND THINKING ABOUT THINGS LIKE

4527
03:01:19,270 --> 03:01:21,105
TRANSPORTATION AND HOUSING AND

4528
03:01:21,105 --> 03:01:23,941
ALL THOSE ISSUES THAT ARE TIED

4529
03:01:23,941 --> 03:01:27,211
TO, IN A WAY, AND THAT

4530
03:01:27,211 --> 03:01:28,312
DEFINITELY IMPACT PEOPLE'S

4531
03:01:28,312 --> 03:01:30,614
HEALTH BUT ARE NOT NECESSARILY

4532
03:01:30,614 --> 03:01:31,816
THINGS THAT WE ULTIMATELY

4533
03:01:31,816 --> 03:01:33,684
NECESSARILY FOCUS ON.

4534
03:01:33,684 --> 03:01:38,155
AND I THINK IN THE COMPASS

4535
03:01:38,155 --> 03:01:39,590
PROGRAM WE'LL SEE THINGS

4536
03:01:39,590 --> 03:01:42,426
RELEVANT TO THAT QUESTION, ASKED

4537
03:01:42,426 --> 03:01:45,062
ABOUT CLIMATE CHANGE AND THE

4538
03:01:45,062 --> 03:01:46,530
ENVIRONMENT.

4539
03:01:46,530 --> 03:01:48,999
>> THANK YOU FOR YOUR

4540
03:01:48,999 --> 03:01:49,433
PRESENTATION.

4541
03:01:49,433 --> 03:01:53,704
I'M THE PRESIDENT AND CEO,

4542
03:01:53,704 --> 03:01:56,006
NATIONAL HISPANIC COUNCIL ON

4543
03:01:56,006 --> 03:01:56,207
AGING.

4544
03:01:56,207 --> 03:01:59,176
YOU MENTIONED THE "ALL OF US"

4545
03:01:59,176 --> 03:02:01,011
PROJECT.

4546
03:02:01,011 --> 03:02:02,346
AND ITS CUTS.

4547
03:02:02,346 --> 03:02:04,115
WHAT MODIFICATIONS WILL YOU BE

4548
03:02:04,115 --> 03:02:08,719
MAKING AS A RESULT OF THOSE

4549
03:02:08,719 --> 03:02:08,919
CUTS?

4550
03:02:08,919 --> 03:02:11,122
>> YEAH, SO THE BUDGET CUT
WE

4551
03:02:11,122 --> 03:02:13,190
TOOK THIS YEAR, FIRST LET ME

4552
03:02:13,190 --> 03:02:15,493
BACK UP AND SAY THIS WAS -- WE

4553
03:02:15,493 --> 03:02:17,795
KNEW THIS WAS COMING BECAUSE

4554
03:02:17,795 --> 03:02:20,631
THIS IS MONEY THAT IS FROM 21ST

4555
03:02:20,631 --> 03:02:23,768
CENTURY CURES SO WE KNEW IT WAS

4556
03:02:23,768 --> 03:02:25,970
ON A 10-YEAR HORIZON.

4557
03:02:25,970 --> 03:02:30,274
SO THIS YEAR THE CUT IS -- WELL,

4558
03:02:30,274 --> 03:02:32,076
YOU HEARD, IT'S THIRTY-SOMETHING

4559
03:02:32,076 --> 03:02:34,445
PERCENT, SIGNIFICANT, BUT WE'RE

4560
03:02:34,445 --> 03:02:35,212
ABLE TO NAVIGATE.

4561
03:02:35,212 --> 03:02:36,947
NEXT YEAR THE CUT IS MUCH, MUCH

4562
03:02:36,947 --> 03:02:38,816
STEEPER AND THE YEAR AFTER THAT

4563
03:02:38,816 --> 03:02:40,351
IT GOES JUST A LITTLE BIT

4564
03:02:40,351 --> 03:02:42,419
FURTHER AND GETS US BASICALLY AT

4565
03:02:42,419 --> 03:02:45,055
OUR BASE, WHICH IS BY THE TIME

4566
03:02:45,055 --> 03:02:46,490
WE THINK ABOUT GETTING TO THAT

4567
03:02:46,490 --> 03:02:48,459
PERIOD OF TIME WE'RE REALLY

4568
03:02:48,459 --> 03:02:51,295
GOING TO BE IN SORT OF

4569
03:02:51,295 --> 03:02:53,364
SUSTAINING THE WORK THAT WE'RE

4570
03:02:53,364 --> 03:02:55,900
CURRENTLY DOING AND SUSTAINING

4571
03:02:55,900 --> 03:03:01,472
THE PLATFORM THAT WE HAVE.

4572
03:03:01,472 --> 03:03:02,807
WHAT ULTIMATELY IS THE REALITY,

4573
03:03:02,807 --> 03:03:05,743
IT'S GOING TO SLOW DOWN,

4574
03:03:05,743 --> 03:03:07,044
TIMELINE TO ACHIEVING GOAL OF

4575
03:03:07,044 --> 03:03:08,379
RECRUITING A MILLION OR MORE

4576
03:03:08,379 --> 03:03:09,780
AMERICANS TO THE STUDY, SO RIGHT

4577
03:03:09,780 --> 03:03:12,516
NOW I THINK WE'RE AT ABOUT -- I

4578
03:03:12,516 --> 03:03:14,885
GOT AN UPDATE FROM JOSH THE

4579
03:03:14,885 --> 03:03:17,121
OTHER DAY, AROUND 800,000

4580
03:03:17,121 --> 03:03:17,521
PEOPLE.

4581
03:03:17,521 --> 03:03:22,693
WE'RE REALLY CLOSE  CLOSE TO THE

4582
03:03:22,693 --> 03:03:24,028
ONE MILLION MARK, BUT IT'S GOING

4583
03:03:24,028 --> 03:03:25,429
TO SLOW DOWN THE WORK WE HAVE

4584
03:03:25,429 --> 03:03:29,600
PLANNED TO DO AND MAY HAVE AN

4585
03:03:29,600 --> 03:03:32,236
IMPACT ON LAUNCHING THE NEXT

4586
03:03:32,236 --> 03:03:36,941
INITIATIVE THAT WAS PLANNED,

4587
03:03:36,941 --> 03:03:39,109
FOCUSING ON PEDIATRICS.

4588
03:03:39,109 --> 03:03:41,245
>> I WOULD ADD "ALL OF US"
IS AN

4589
03:03:41,245 --> 03:03:42,313
OPPORTUNITY FOR COLLABORATION

4590
03:03:42,313 --> 03:03:44,748
WITH INSTITUTES AND CENTERS TO

4591
03:03:44,748 --> 03:03:46,050
LEVERAGE "ALL OF US,"

4592
03:03:46,050 --> 03:03:48,319
COLLABORATE IN THEIR OWN EFFORTS

4593
03:03:48,319 --> 03:03:49,453
WHICH REPRESENT ANOTHER SOURCE

4594
03:03:49,453 --> 03:03:50,821
POTENTIALLY OF FUNDING FOR AREAS

4595
03:03:50,821 --> 03:03:52,957
OF JOINT AND COME AN INTEREST

4596
03:03:52,957 --> 03:03:53,257
ACROSS NIH.

4597
03:03:53,257 --> 03:03:54,925
>> YEAH, AND WE CALL THEM

4598
03:03:54,925 --> 03:03:55,993
ANCILLARY STUDIES THAT WE'RE

4599
03:03:55,993 --> 03:03:57,328
WORKING WITH INSTITUTES AND

4600
03:03:57,328 --> 03:03:59,496
CENTERS ON, THOSE HAVE ONLY BEEN

4601
03:03:59,496 --> 03:04:02,032
KIND OF RAMPING UP OVER THE LAST

4602
03:04:02,032 --> 03:04:06,203
MAYBE TWO OR SO YEARS.

4603
03:04:06,203 --> 03:04:08,572
AND I THINK WE'RE OPTIMISTIC

4604
03:04:08,572 --> 03:04:10,241
WE'LL CONTINUE TO SEE A LOT MORE

4605
03:04:10,241 --> 03:04:11,642
ANCILLARY STUDIES BEING INVOLVED

4606
03:04:11,642 --> 03:04:22,152
IN THE NETWORK GOING FORWARD.

4607
03:04:22,586 --> 03:04:23,754
>> ONE OVERARCHING
QUESTIONS,

4608
03:04:23,754 --> 03:04:30,461
IT'S MORE ON THE LINES OF

4609
03:04:30,461 --> 03:04:31,362
PRIORITIZATION AND

4610
03:04:31,362 --> 03:04:32,663
SUSTAINABILITY FOR COMPLEXITY OF

4611
03:04:32,663 --> 03:04:34,498
OFFICE OF DPCPSI, 16 DIFFERENT

4612
03:04:34,498 --> 03:04:37,801
OFFICES, ALL WITH DIFFERENT

4613
03:04:37,801 --> 03:04:38,702
AGENDAS.

4614
03:04:38,702 --> 03:04:41,505
HOW DO YOU NAVIGATE WITH SUCH A

4615
03:04:41,505 --> 03:04:42,907
COMPLEX GROUP ALL THOSE

4616
03:04:42,907 --> 03:04:45,342
DIFFERENT PRIORITIES,

4617
03:04:45,342 --> 03:04:47,544
LIMITATIONS ON THE BUDGET, HOW

4618
03:04:47,544 --> 03:04:49,713
TO SUSTAIN EXISTING PROGRAMS OR

4619
03:04:49,713 --> 03:04:50,814
THOSE PROGRAMS THAT ARE JUST

4620
03:04:50,814 --> 03:04:54,551
PILOTS AND THINGS LIKE THAT AND

4621
03:04:54,551 --> 03:04:58,022
HOW TO FURTHER THEM ALONG.

4622
03:04:58,022 --> 03:05:01,525
>> I SHOULD MAKE SURE TO

4623
03:05:01,525 --> 03:05:03,861
EMPHASIZE STRUCTURE WITHIN

4624
03:05:03,861 --> 03:05:06,797
DPCPSI, MOST OFFICES ARE

4625
03:05:06,797 --> 03:05:08,098
CONGRESSIONALLY MANDATED AND

4626
03:05:08,098 --> 03:05:08,899
PLACED WITHIN DPCPSI.

4627
03:05:08,899 --> 03:05:13,570
SO LET ME JUST SAY THAT

4628
03:05:13,570 --> 03:05:13,837
OUTRIGHT.

4629
03:05:13,837 --> 03:05:15,439
ALIGNMENT WITH STRUCTURE ACROSS

4630
03:05:15,439 --> 03:05:17,508
NIH, 27 INSTITUTES AND CENTERS

4631
03:05:17,508 --> 03:05:18,475
BEING CONGRESSIONALLY MANDATED.

4632
03:05:18,475 --> 03:05:19,977
THEY EACH HAVE THEIR OWN, FOR

4633
03:05:19,977 --> 03:05:21,879
THE MOST PART, THERE ARE A FEW

4634
03:05:21,879 --> 03:05:26,383
EXCEPTIONS, BUT THEY EACH HAVE

4635
03:05:26,383 --> 03:05:28,552
THEIR OWN LINE ITEM

4636
03:05:28,552 --> 03:05:29,153
APPROPRIATION.

4637
03:05:29,153 --> 03:05:32,723
SOME HAVE SPECIFIC THINGS THEY 

4638
03:05:32,723 --> 03:05:34,358
ARE TASKED WITH DOING, OTHERS

4639
03:05:34,358 --> 03:05:35,459
HAVE MORE FLEXIBILITY.

4640
03:05:35,459 --> 03:05:37,227
ONE THING WE'VE BEEN TALKING

4641
03:05:37,227 --> 03:05:39,196
ABOUT A LOT SINCE I STARTED OVER

4642
03:05:39,196 --> 03:05:41,465
THE LAST SIX MONTHS HERE AT

4643
03:05:41,465 --> 03:05:43,467
DPCPSI IS TO THINK ABOUT WAYS

4644
03:05:43,467 --> 03:05:45,536
THAT WE CAN WORK TOGETHER AND

4645
03:05:45,536 --> 03:05:46,971
LEVERAGE THE SCIENCE THAT WE'RE

4646
03:05:46,971 --> 03:05:47,972
DOING ACROSS THE BOARD BECAUSE

4647
03:05:47,972 --> 03:05:52,443
AS I SAID ALL OF THE AREAS WE'RE

4648
03:05:52,443 --> 03:05:56,914
WORKING ON ARE SUPPOSED TO BE

4649
03:05:56,914 --> 03:05:58,916
CROSS-CUTTING SUPPORTING WORK

4650
03:05:58,916 --> 03:06:00,851
WHAT CENTERS DO, AS WE'RE

4651
03:06:00,851 --> 03:06:02,052
THINKING ABOUT WOMEN'S HEALTH

4652
03:06:02,052 --> 03:06:04,355
ALSO ASKING QUESTIONS RELATED TO

4653
03:06:04,355 --> 03:06:05,456
BEHAVIORAL AND SOCIAL SCIENCES

4654
03:06:05,456 --> 03:06:06,323
RESEARCH, THINKING ABOUT THOSE

4655
03:06:06,323 --> 03:06:07,758
QUESTIONS AS WELL AS QUESTIONS

4656
03:06:07,758 --> 03:06:10,928
AROUND DISEASE PREVENTION AND

4657
03:06:10,928 --> 03:06:11,795
WHERE THOSE INTERSECTION POINTS

4658
03:06:11,795 --> 03:06:16,700
ARE SO WE CAN MAXIMIZE THE SORT 

4659
03:06:16,700 --> 03:06:19,336
OF IMPACT THAT WE HAVE NOT JUST

4660
03:06:19,336 --> 03:06:21,205
WITHIN DPCPSI BUT WORKING WITH

4661
03:06:21,205 --> 03:06:23,407
I.C.s AND ACROSS THE BOARD FOR

4662
03:06:23,407 --> 03:06:26,110
THE COMMUNITY.

4663
03:06:26,110 --> 03:06:34,451
 

4664
03:06:34,451 --> 03:06:35,886
>> NANCY FROM AMERICAN
GERIATRIC

4665
03:06:35,886 --> 03:06:36,120
SOCIETY.

4666
03:06:36,120 --> 03:06:37,955
I'M REALLY INTERESTED IN THE

4667
03:06:37,955 --> 03:06:39,923
PRIMARY CARE NETWORK BUT ALSO

4668
03:06:39,923 --> 03:06:42,092
THE DATA INFRASTRUCTURE AND I

4669
03:06:42,092 --> 03:06:48,032
KNOW THEY ARE NOT COMPLETELY 

4670
03:06:48,032 --> 03:06:48,766
INTERTWINED.

4671
03:06:48,766 --> 03:06:50,934
BUT SPECIFICALLY, WE COORDINATE

4672
03:06:50,934 --> 03:06:54,705
GERIATRIC ENHANCEMENT PROGRAM, 

4673
03:06:54,705 --> 03:06:56,073
WE HAVE A COORDINATING CENTER

4674
03:06:56,073 --> 03:06:56,573
FOR THAT.

4675
03:06:56,573 --> 03:07:02,179
ONE OF THE THINGS WE HEAR, THE

4676
03:07:02,179 --> 03:07:05,115
DIFFICULTY THEY HAVE IN

4677
03:07:05,115 --> 03:07:06,784
STRUCTURING EHRs TO REPORT

4678
03:07:06,784 --> 03:07:08,519
DATA INTO A CENTRAL REPOSITORY

4679
03:07:08,519 --> 03:07:10,487
OF ANY SORT OR EVEN JUST TO BE

4680
03:07:10,487 --> 03:07:12,790
ABLE TO PULL DATA.

4681
03:07:12,790 --> 03:07:15,092
I'M WONDERING WITHIN THE CONTEXT

4682
03:07:15,092 --> 03:07:18,062
OF SETTING UP SUCH A BIG DATA

4683
03:07:18,062 --> 03:07:19,897
INFRASTRUCTURE IS THERE GOING TO

4684
03:07:19,897 --> 03:07:24,034
BE FUNDING FOR PRIMARY CARE

4685
03:07:24,034 --> 03:07:25,903
PRACTICES AND FQHCs TO BE ABLE

4686
03:07:25,903 --> 03:07:29,306
TO SET THEMSELVES UP TO SUBMIT

4687
03:07:29,306 --> 03:07:29,506
DATA?

4688
03:07:29,506 --> 03:07:32,142
>> YEAH, THAT'S A GREAT
POINT.

4689
03:07:32,142 --> 03:07:34,011
THAT'S SOMETHING, THIS IS ONE OF

4690
03:07:34,011 --> 03:07:35,646
THOSE AREAS WHERE THOSE TWO

4691
03:07:35,646 --> 03:07:36,413
DEFINITELY INTERSECT.

4692
03:07:36,413 --> 03:07:40,117
WE'VE BEEN THINKING ABOUT THAT A

4693
03:07:40,117 --> 03:07:40,350
LOT.

4694
03:07:40,350 --> 03:07:44,488
AND ONE OF THE MANY REASONS WHY

4695
03:07:44,488 --> 03:07:52,963
WE'RE FOCUSING  OUR IDeA

4696
03:07:52,963 --> 03:07:54,798
STATES, CLINICAL AND

4697
03:07:54,798 --> 03:07:55,599
TRANSLATIONAL NETWORK, THEY

4698
03:07:55,599 --> 03:07:56,767
PARTNERED WITH OFFICE OF DATA

4699
03:07:56,767 --> 03:07:57,868
STRATEGY TO BUILD CAPABILITIES

4700
03:07:57,868 --> 03:07:58,902
IN SOME SETTINGS SO WE'RE

4701
03:07:58,902 --> 03:08:00,270
STARTING TO SEE A LITTLE BIT

4702
03:08:00,270 --> 03:08:02,139
ABOUT WHY HAS WORKED AND WHAT

4703
03:08:02,139 --> 03:08:04,975
HASN'T WORKED AND WE'RE KIND OF

4704
03:08:04,975 --> 03:08:07,711
LOOKING AT THIS WHOLE EFFORT,

4705
03:08:07,711 --> 03:08:09,580
ACTUALLY BOTH REALLY, AS SORT OF

4706
03:08:09,580 --> 03:08:10,881
TRYING TO FIGURE OUT WHAT WORKS

4707
03:08:10,881 --> 03:08:12,282
AND WHAT WORKS BEST AND WE'RE

4708
03:08:12,282 --> 03:08:14,618
TRYING TO BUILD IN PARTICULAR

4709
03:08:14,618 --> 03:08:16,353
THE PRIMARY CARE NETWORK TO BE

4710
03:08:16,353 --> 03:08:18,122
AS NIMBLE AND FLEXIBLE AS

4711
03:08:18,122 --> 03:08:19,756
POSSIBLE SO WE CAN ADAPT TO

4712
03:08:19,756 --> 03:08:21,758
THINGS THAT COME UP LIKE IF THAT

4713
03:08:21,758 --> 03:08:23,393
BECOMES A MAJOR, MAJOR ISSUE,

4714
03:08:23,393 --> 03:08:27,764
HOW CAN WE THEN KIND OF SHIFT

4715
03:08:27,764 --> 03:08:29,766
OUR FOCUS, AT LEAST PART OF THE

4716
03:08:29,766 --> 03:08:32,669
FOCUS, TO SUPPORT THOSE SITES

4717
03:08:32,669 --> 03:08:35,205
DIFFERENTLY OR TO BE ABLE TO PUT

4718
03:08:35,205 --> 03:08:38,675
MORE EFFORT ON BEING ABLE TO

4719
03:08:38,675 --> 03:08:39,476
SUPPORT THE TRANSITION FROM

4720
03:08:39,476 --> 03:08:40,577
PAPER WHICH WE'VE HEARD FROM

4721
03:08:40,577 --> 03:08:42,079
SOME OF THE SITES THAT WE'VE

4722
03:08:42,079 --> 03:08:44,715
BEEN TALKING TO THAT SOME ARE

4723
03:08:44,715 --> 03:08:45,282
STILL ON PAPER.

4724
03:08:45,282 --> 03:08:48,318
TO BE ABLE TO GET IT DIGITAL,

4725
03:08:48,318 --> 03:08:50,621
MUCH LESS ANYTHING FURTHER DOWN

4726
03:08:50,621 --> 03:08:51,922
THE ROAD AND MORE COMPLICATED.

4727
03:08:51,922 --> 03:08:53,690
SO WE'RE GOING TO BE LEARNING A

4728
03:08:53,690 --> 03:08:57,394
LOT AS WE GO ALONG, AND I SHOULD

4729
03:08:57,394 --> 03:09:02,900
MENTION TO YOU ALL THAT WE'RE

4730
03:09:02,900 --> 03:09:05,369
HAVING A LISTENING SESSION FOR

4731
03:09:05,369 --> 03:09:09,339
THE ROA, FOR THE PRIMARY CARE

4732
03:09:09,339 --> 03:09:10,541
NETWORK, HAPPENING TODAY BUT

4733
03:09:10,541 --> 03:09:15,612
WE'RE PLANNING FOR A BIG KIND OF

4734
03:09:15,612 --> 03:09:16,346
WORKSHOP TYPE LISTENING SESSION.

4735
03:09:16,346 --> 03:09:17,548
I DON'T KNOW WHAT WE'RE GOING TO

4736
03:09:17,548 --> 03:09:18,749
CALL IT.

4737
03:09:18,749 --> 03:09:21,785
BUT A BIG EVENT ON JUNE 7 WHERE

4738
03:09:21,785 --> 03:09:23,453
WE'RE GOING TO TALK A LOT MORE

4739
03:09:23,453 --> 03:09:25,222
ABOUT THE WORK THAT WE'RE DOING

4740
03:09:25,222 --> 03:09:26,190
AND ABOUT WHAT WE'VE BEEN

4741
03:09:26,190 --> 03:09:27,391
HEARING FROM THE COMMUNITIES AND

4742
03:09:27,391 --> 03:09:30,127
HAVE AN OPPORTUNITY TO BE ABLE

4743
03:09:30,127 --> 03:09:31,762
TO HAVE SOME REALLY OPEN PUBLIC

4744
03:09:31,762 --> 03:09:33,096
DISCUSSIONS ABOUT THIS.

4745
03:09:33,096 --> 03:09:35,165
I WOULD ENCOURAGE YOU TO SHARE

4746
03:09:35,165 --> 03:09:36,600
THAT WITH YOUR COLLEAGUES AND

4747
03:09:36,600 --> 03:09:40,204
TUNE IN AND LET US KNOW, WE

4748
03:09:40,204 --> 03:09:42,306
WOULD APPRECIATE YOUR FEEDBACK

4749
03:09:42,306 --> 03:09:43,840
ON ANYTHING BECAUSE THOSE

4750
03:09:43,840 --> 03:09:45,709
ISSUES, YOU'RE NOT ALONE.

4751
03:09:45,709 --> 03:09:50,247
WE'VE HEARD THEM MANY TIMES.

4752
03:09:50,247 --> 03:09:52,683
>> TARA, AS WE GET
ANNOUNCEMENTS

4753
03:09:52,683 --> 03:09:54,351
OF THEM WE'LL CIRCULATE

4754
03:09:54,351 --> 03:09:56,954
SPECIFICALLY TO AUDIENCES,

4755
03:09:56,954 --> 03:09:58,889
INCLUDING YOU, OUR COUNCIL

4756
03:09:58,889 --> 03:09:59,356
MEMBERS.

4757
03:09:59,356 --> 03:10:00,357
>> ALL RIGHT.

4758
03:10:00,357 --> 03:10:02,659
IF THERE'S NO FURTHER QUESTIONS,

4759
03:10:02,659 --> 03:10:04,761
TARA, WE THANK YOU VERY MUCH.

4760
03:10:04,761 --> 03:10:05,162
VERY INFORMATIVE.

4761
03:10:05,162 --> 03:10:06,597
>> THANK YOU ALL.

4762
03:10:06,597 --> 03:10:07,698
I APPRECIATE THE OPPORTUNITY.

4763
03:10:07,698 --> 03:10:11,969
THANK YOU. 

4764
03:10:11,969 --> 03:10:14,037
>> ALL RIGHT.

4765
03:10:14,037 --> 03:10:16,006
AND THEN THAT CONCLUDES OUR

4766
03:10:16,006 --> 03:10:17,975
COUNCIL MEETING FOR THIS ROUND.

4767
03:10:17,975 --> 03:10:21,245
AGAIN, I WANT TO THANK OUR

4768
03:10:21,245 --> 03:10:21,912
COUNCIL MEMBERS, ESPECIALLY, FOR

4769
03:10:21,912 --> 03:10:23,981
THE WORK THEY PUT IN, THEIR

4770
03:10:23,981 --> 03:10:25,849
ADVICE AND CONDUCT FOR THIS

4771
03:10:25,849 --> 03:10:26,183
MEETING.

4772
03:10:26,183 --> 03:10:28,585
WE GREATLY APPRECIATE IT.

4773
03:10:28,585 --> 03:10:29,686
SAFE TRAVELS BACK.

4774
03:10:29,686 --> 03:10:32,456
>> THANKS, ALL OF YOU, FOR
AN

4775
03:10:32,456 --> 03:10:33,323
EXTRAORDINARILY INTERACTIVE

4776
03:10:33,323 --> 03:10:36,593
MEETING, AND TARA, FOR A GREAT

4777
03:10:36,593 --> 03:10:37,494
FINISH.

4778
03:10:37,494 --> 03:10:38,862
ONE LAST TIME, SESSION'S CLOSED.

4779
03:10:38,862 --> 03:10:41,398
[END OF PROGRAM]

4780
03:10:41,398 --> 03:10:47,404
 

4781
03:10:47,404 --> 03:10:57,447