1 00:00:37,337 --> 00:00:42,108 >> SO AS WE CALL YOUR NAME 2 00:00:42,108 --> 00:00:43,977 PLEASE INTRODUCE YOURSELF AND 3 00:00:43,977 --> 00:00:54,287 YOUR INSTITUTION. 4 00:01:47,273 --> 00:01:57,417 [ROLL CALL]. 5 00:04:36,209 --> 00:04:37,143 >> I WOULD LIKE TO OPEN WITH A 6 00:04:37,143 --> 00:04:37,710 PRESENTATION SUMMARIZING THE 7 00:04:37,710 --> 00:04:41,714 STATE OF THINGS. 8 00:04:41,714 --> 00:04:44,450 FIRST SADLY SHARING NEWS OF THE 9 00:04:44,450 --> 00:04:49,088 RECENT PASSING OF JUDY. 10 00:04:49,088 --> 00:04:59,332 WE HAVE KNOWN HER. 11 00:04:59,332 --> 00:05:08,908 AND INCLUDING MEMBERSHIP AS A 12 00:05:08,908 --> 00:05:09,208 NACA MEMBER. 13 00:05:09,208 --> 00:05:09,909 IT IS TRAGIC AND A LOSS FOR ALL 14 00:05:09,909 --> 00:05:11,911 OF US. 15 00:05:11,911 --> 00:05:15,348 WE LIKE TO TAKE A MOMENT IF 16 00:05:15,348 --> 00:05:16,349 ANYBODY ELSE WOULD LIKE TO MAKE 17 00:05:16,349 --> 00:05:26,592 SOME COMMENTS? 18 00:05:32,598 --> 00:05:33,132 >> THIS IS CHARLOTTE PETERSON 19 00:05:33,132 --> 00:05:36,536 WHY THE TRAGIC LOSS. 20 00:05:36,536 --> 00:05:37,136 JUDY WAS VERY INSTRUMENTAL IN 21 00:05:37,136 --> 00:05:39,172 ENTERING THE FIELD. 22 00:05:39,172 --> 00:05:40,139 SHE WILL BE SORELY MISSED. 23 00:05:40,139 --> 00:05:43,709 I CANNOT TELL YOU HOW MUCH SHE 24 00:05:43,709 --> 00:05:45,478 INFLUENCED MY CAREER. 25 00:05:45,478 --> 00:05:49,148 >> I WOULD LIKE TO MAKE SOME 26 00:05:49,148 --> 00:05:50,616 COMMENTS ON BEHALF. 27 00:05:50,616 --> 00:05:54,620 SHE WAS A LONG TIME GRANTEE WITH 28 00:05:54,620 --> 00:06:00,259 SIGNIFICANT CONTRIBUTIONS. 29 00:06:00,259 --> 00:06:04,263 SHE PARTICIPATED IN LOTS OF 30 00:06:04,263 --> 00:06:05,998 MEETINGS AND WORKSHOPS OVER THE 31 00:06:05,998 --> 00:06:10,436 YEARS AND IS ON LEADERSHIP ROLES 32 00:06:10,436 --> 00:06:12,972 AND NIH PROGRAMS AS WELL MOST 33 00:06:12,972 --> 00:06:23,483 RECENTLY IN WITH THE GUIDANCE 34 00:06:25,518 --> 00:06:31,190 AND EXPERTISE. 35 00:06:31,190 --> 00:06:35,027 THAT WAS QUITE SIGNIFICANT. 36 00:06:35,027 --> 00:06:41,901 AND BEYOND RESEARCH TALENTS AND 37 00:06:41,901 --> 00:06:52,145 ALSO HOLD ON THAT WAS QUITE 38 00:06:52,145 --> 00:06:52,945 IMPRESSIVE IN HER DEATH IS A 39 00:06:52,945 --> 00:07:03,055 MAJOR LOSS FOR US. 40 00:07:03,055 --> 00:07:04,590 >> JUDY HAS BEEN VERY 41 00:07:04,590 --> 00:07:09,128 INFLUENTIAL WITH THE THINGS WE 42 00:07:09,128 --> 00:07:09,629 HAVE BEEN INTERESTED IN. 43 00:07:09,629 --> 00:07:15,368 AND IS 1 OF THE RARE PEOPLE AND 44 00:07:15,368 --> 00:07:16,335 THE PLEASANTNESS OF MEETING HER 45 00:07:16,335 --> 00:07:23,910 AND HELP PRESENT SHE WAS. 46 00:07:23,910 --> 00:07:24,510 AND THEN TO PICK UP THE PHONE 47 00:07:24,510 --> 00:07:25,411 AND CALL HER TO SAY DOES THIS 48 00:07:25,411 --> 00:07:31,984 MAKE SENSE I HAVE KNOWN HER 49 00:07:31,984 --> 00:07:32,752 REALISTICALLY AT LEAST 15 YEARS 50 00:07:32,752 --> 00:07:43,196 NOW AT THIS POINT IN TIME. 51 00:07:48,000 --> 00:07:48,568 IT IS A LOSS FOR THE FIELD JUST 52 00:07:48,568 --> 00:07:49,202 BASED ON HOW HIM AS SHE WAS WITH 53 00:07:49,202 --> 00:07:49,802 SO MANY DIFFERENT PROJECTS AND 54 00:07:49,802 --> 00:07:50,403 WILLING TO SHARE HER KNOWLEDGE 55 00:07:50,403 --> 00:07:53,873 AS WELL AS EXPERTISE. 56 00:07:53,873 --> 00:07:54,507 IT WILL BE A TREMENDOUS LOSS FOR 57 00:07:54,507 --> 00:08:04,951 US IN THE SPACE FOR SURE. 58 00:08:12,758 --> 00:08:23,202 >> I JUST SAID WHAT A LEGACY. 59 00:08:24,103 --> 00:08:24,570 >> AWARE PERSON AS WELL AS 60 00:08:24,570 --> 00:08:31,777 SCIENTIST AND WE WILL MISS HER. 61 00:08:31,777 --> 00:08:32,812 SO NOW WE WILL MOVE TO THE NEXT 62 00:08:32,812 --> 00:08:36,115 SLIDE. 63 00:08:36,115 --> 00:08:43,556 >> WE DO WILL WHERE WE ARE THIS 64 00:08:43,556 --> 00:08:53,766 CLEAR 2024. 65 00:08:54,066 --> 00:08:54,467 WE BEGAN THE YEAR WITH 66 00:08:54,467 --> 00:08:55,067 APPROPRIATION WE ARE UNDER THE 67 00:08:55,067 --> 00:08:55,568 RESOLUTION KEEPING US IN 68 00:08:55,568 --> 00:08:56,202 BUSINESS THROUGH MARCH 8, 2024. 69 00:08:56,202 --> 00:09:01,774 AT THAT POINT THERE WILL BE 70 00:09:01,774 --> 00:09:02,375 APPROPRIATION OR A FURTHERING 71 00:09:02,375 --> 00:09:02,975 RESOLUTION WE WILL TRACK THIS 72 00:09:02,975 --> 00:09:03,342 VERY CAREFULLY. 73 00:09:03,342 --> 00:09:03,976 IN THE MEANTIME IT MEANS WE HAVE 74 00:09:03,976 --> 00:09:06,279 TO BE VERY CAUTIOUS OF FUNDS 75 00:09:06,279 --> 00:09:15,888 AVAILABLE AND PAY LOANS. 76 00:09:15,888 --> 00:09:16,522 AS REFLECTED HERE IN THE INTERIM 77 00:09:16,522 --> 00:09:17,089 ALLOCATIONS OF WHICH WE ARE 78 00:09:17,089 --> 00:09:18,491 FUNDING UNTIL WE KNOW WHERE 79 00:09:18,491 --> 00:09:19,859 BUDGET FOR THE GENERAL PAY 80 00:09:19,859 --> 00:09:29,935 LINE. 81 00:09:29,935 --> 00:09:31,470 AND PAY LINE HERE FOR THE 82 00:09:31,470 --> 00:09:38,911 PERCENTILE 11 THROUGH 13 AND 83 00:09:38,911 --> 00:09:39,845 HIGHER BAR FOR THE MORE 84 00:09:39,845 --> 00:09:43,683 EXPENSIVE AWARDS WE WILL HAVE 85 00:09:43,683 --> 00:09:53,292 THE PAY LINES A QUITE 86 00:09:53,292 --> 00:09:53,926 SUBSTANTIAL DECREASE ON THE PAY 87 00:09:53,926 --> 00:09:58,331 LINE HERE WITH 12 PERCENT 15 AND 88 00:09:58,331 --> 00:10:01,701 17 PERCENT AND FOR THOSE MORE 89 00:10:01,701 --> 00:10:09,608 EXPENSIVE ALZHEIMER'S WORDS 90 00:10:09,608 --> 00:10:10,242 $500,000,000.10 PERCENT OFF AND 91 00:10:10,242 --> 00:10:10,843 THEN 15 AND 13 THE NEXT SLIDE 92 00:10:10,843 --> 00:10:12,845 ILLUSTRATES THE SAME FOR OVERALL 93 00:10:12,845 --> 00:10:16,649 IMPACT SCORES. 94 00:10:16,649 --> 00:10:17,717 MUCH BELOW WHERE WE HAVE BEEN IN 95 00:10:17,717 --> 00:10:25,191 PRIOR YEARS AND WE ARE HOPEFUL 96 00:10:25,191 --> 00:10:27,827 THAT THESE WILL BE MODIFIED AND 97 00:10:27,827 --> 00:10:33,265 IMPROVED IN THE BUDGET PROCESS 98 00:10:33,265 --> 00:10:33,899 AND THEN WE JUST HAVE TO REMAIN 99 00:10:33,899 --> 00:10:34,467 CAUTIOUS AND WE WILL KEEP IN 100 00:10:34,467 --> 00:10:38,704 TOUCH WITH YOU. 101 00:10:38,704 --> 00:10:39,305 BUT WERE LIKELY TO LEARN MORE 102 00:10:39,305 --> 00:10:45,644 BEFORE THE MARCH 8 DEADLINE. 103 00:10:45,644 --> 00:10:48,180 SO WE JUST WANT TO SUMMARIZE THE 104 00:10:48,180 --> 00:10:49,248 PROGRESS OF THE CLINICAL 105 00:10:49,248 --> 00:10:51,016 TRIALS. 106 00:10:51,016 --> 00:10:53,753 THOSE THAT ARE SUPPORTED AND 107 00:10:53,753 --> 00:11:01,927 NEARLY HALF OF THOSE ARE GIVING 108 00:11:01,927 --> 00:11:02,461 CARE AND OTHERS ARE IN THE 109 00:11:02,461 --> 00:11:03,028 CATEGORIES OF TREATMENT AND 110 00:11:03,028 --> 00:11:07,466 PREVENTION. 111 00:11:07,466 --> 00:11:07,933 SO PHARMACOLOGICAL AND 112 00:11:07,933 --> 00:11:12,304 NONPHARMACOLOGICAL INTERVENTIONS 113 00:11:12,304 --> 00:11:12,872 WE DON'T WANT TO STRESS THE 114 00:11:12,872 --> 00:11:14,874 NUMBERS BUT THE DIVERSITY OF 115 00:11:14,874 --> 00:11:25,151 TARGETS THE BUT 116 00:11:39,965 --> 00:11:41,000 THE EARLIER STAGE PHASE 1 AND 117 00:11:41,000 --> 00:11:42,401 2. 118 00:11:42,401 --> 00:11:49,842 DIVERSITY IS QUITE REMARKABLE 119 00:11:49,842 --> 00:11:50,876 AND THE OTHERS THAT ARE 120 00:11:50,876 --> 00:11:52,645 EMERGING. 121 00:11:52,645 --> 00:11:59,118 WITH THE NONPHARMACOLOGICAL 122 00:11:59,118 --> 00:12:03,789 REFLECTS THE WAY THE BASIC 123 00:12:03,789 --> 00:12:05,224 RESEARCH AS WELL AS THE 124 00:12:05,224 --> 00:12:07,226 TRANSLATION THROUGH THE CLINICAL 125 00:12:07,226 --> 00:12:17,236 TRIALS. 126 00:12:17,236 --> 00:12:19,772 AND THAT IS BUILDING UPON PAST 127 00:12:19,772 --> 00:12:21,841 RESEARCH READY FOR THE 128 00:12:21,841 --> 00:12:30,249 DISSEMINATION. 129 00:12:30,249 --> 00:12:30,749 AND WITH THE HEALTH AND 130 00:12:30,749 --> 00:12:31,250 WELL-BEING WITH THE CARE 131 00:12:31,250 --> 00:12:31,884 PROVIDERS AND CAREGIVERS AS WELL 132 00:12:31,884 --> 00:12:32,518 AS INSTITUTIONAL SETTINGS AND SO 133 00:12:32,518 --> 00:12:33,853 ON. 134 00:12:33,853 --> 00:12:42,628 ALSO WITH DIAGNOSTIC IMAGING AND 135 00:12:42,628 --> 00:12:43,095 OTHER TOOLS AND OTHER 136 00:12:43,095 --> 00:12:43,829 PSYCHIATRIC SYMPTOMS SO IT IS 137 00:12:43,829 --> 00:12:44,396 QUITE A REMARKABLE EXPANSION 138 00:12:44,396 --> 00:12:45,431 WITH THE DIVERSITY TARGETS AS WE 139 00:12:45,431 --> 00:12:50,002 ALL RECOGNIZE A PROCESS WITH 140 00:12:50,002 --> 00:12:53,038 INDIVIDUALS SET OF CONTRIBUTING 141 00:12:53,038 --> 00:12:55,608 CAUSES THAT HAVE BEEN ADDRESSED 142 00:12:55,608 --> 00:13:03,115 BY VERY TARGETED TRIALS. 143 00:13:03,115 --> 00:13:03,749 NEXT FOR THE ONGOING ACTIVITY AT 144 00:13:03,749 --> 00:13:11,991 THE REQUEST OF CONGRESS WITH THE 145 00:13:11,991 --> 00:13:12,591 NATIONAL ACADEMIES AND THEN TO 146 00:13:12,591 --> 00:13:18,163 IDENTIFY PRIORITIES WITH THE 147 00:13:18,163 --> 00:13:19,532 RESEARCH PRIORITIES THROUGH 148 00:13:19,532 --> 00:13:24,904 TRANSLATION LOOKING FOR GAPS AND 149 00:13:24,904 --> 00:13:25,504 RECOMMENDED PRIORITIES AND THE 150 00:13:25,504 --> 00:13:26,105 COMMITTEE WAS ESTABLISHED THE 151 00:13:26,105 --> 00:13:28,207 FOLLOWING LAST YEAR THE MOST 152 00:13:28,207 --> 00:13:33,746 RECENT OF WHICH WAS LAST WEEK. 153 00:13:33,746 --> 00:13:39,151 WE HAD A REPORT IN EARLY 2025. 154 00:13:39,151 --> 00:13:40,119 LOOK AT THE PUBLIC SESSIONS WHEN 155 00:13:40,119 --> 00:13:46,525 AVAILABLE. 156 00:13:46,525 --> 00:13:47,159 THIS IS A WELCOME BIT OF INFO TO 157 00:13:47,159 --> 00:13:47,326 US. 158 00:13:47,326 --> 00:13:47,960 WE ARE GRATEFUL FOR ALL OF THOSE 159 00:13:47,960 --> 00:13:48,594 PARTICIPATING AS WELL AS THOSE 160 00:13:48,594 --> 00:13:48,928 ON THE PANEL. 161 00:13:48,928 --> 00:13:51,030 THE MORE INPUT WE HAVE THE 162 00:13:51,030 --> 00:13:54,033 BETTER INFORMED RESEARCH 163 00:13:54,033 --> 00:13:55,067 PRIORITIES AND THE BETTER FOR 164 00:13:55,067 --> 00:14:01,473 ALL. 165 00:14:01,473 --> 00:14:08,013 WE HAVE A DELIGHTFUL OPPORTUNITY 166 00:14:08,013 --> 00:14:13,352 SOME OF YOU MAY RECALL WITH THE 167 00:14:13,352 --> 00:14:20,593 LEADERSHIP WITH THE SPECIAL 168 00:14:20,593 --> 00:14:21,226 POPULATIONS WE HAVE OUTREACH IN 169 00:14:21,226 --> 00:14:25,364 THE I CHING COMMUNITIES. 170 00:14:25,364 --> 00:14:25,998 WE TOOK SOME ADVANTAGE OF SUCH A 171 00:14:25,998 --> 00:14:36,375 VISIT WITH LEADERSHIP. 172 00:14:43,082 --> 00:14:43,482 AND IT WAS A FANTASTIC 173 00:14:43,482 --> 00:14:44,016 OPPORTUNITY TO SEE A VERY 174 00:14:44,016 --> 00:14:44,617 IMPRESSIVE MEDICAL SCHOOL THAT 175 00:14:44,617 --> 00:14:45,217 HAS NOW BEEN DEVELOPED AS WELL 176 00:14:45,217 --> 00:14:45,818 AS RESEARCH SETTINGS OVER THE 177 00:14:45,818 --> 00:14:48,721 PAST YEAR AND WE APPRECIATE 178 00:14:48,721 --> 00:14:57,463 THEIR WILLINGNESS TO HOST US. 179 00:14:57,463 --> 00:15:07,940 AND THEN AND EXEMPLAR AND IN 180 00:15:08,841 --> 00:15:11,243 ADDITION TO MEETING WITH THE 181 00:15:11,243 --> 00:15:11,610 CHEROKEE NATION. 182 00:15:11,610 --> 00:15:17,950 WE ARE OKLAHOMA STATE COLLEGE OF 183 00:15:17,950 --> 00:15:18,450 MEDICINE AT THE CHEROKEE 184 00:15:18,450 --> 00:15:18,684 NATION. 185 00:15:18,684 --> 00:15:19,284 THE ONLY COLLEGE OF MEDICINE A 186 00:15:19,284 --> 00:15:19,885 NATIVE AMERICAN SOVEREIGN LAND 187 00:15:19,885 --> 00:15:21,253 IN THE COUNTRY. 188 00:15:21,253 --> 00:15:22,254 THE REGIONAL MEETING THE 189 00:15:22,254 --> 00:15:24,523 FOLLOWING DAY HELD AT OKLAHOMA 190 00:15:24,523 --> 00:15:29,461 STATE UNIVERSITY. 191 00:15:29,461 --> 00:15:30,095 BROUGHT TO GATHER PARTNERS FROM 192 00:15:30,095 --> 00:15:32,131 A VARIETY OF INSTITUTIONS MANY 193 00:15:32,131 --> 00:15:35,501 THAT ARE NOT FAMILIAR WITH NIH 194 00:15:35,501 --> 00:15:39,505 RESEARCH IN GENERAL. 195 00:15:39,505 --> 00:15:41,040 AND TO BRING THESE VARIOUS 196 00:15:41,040 --> 00:15:46,111 COMMUNITIES TO ESTABLISH 197 00:15:46,111 --> 00:15:46,745 RELATIONSHIPS WHICH WE HOPE WILL 198 00:15:46,745 --> 00:15:56,422 LEAD TO THEIR ENGAGEMENT AND AND 199 00:15:56,422 --> 00:15:56,889 LEADERSHIP FROM THOSE 200 00:15:56,889 --> 00:15:57,489 INSTITUTIONS DASH AND SERVICE 201 00:15:57,489 --> 00:15:58,057 WELL TO FURTHER THE CAUSE OF 202 00:15:58,057 --> 00:15:58,624 OUTREACH AND INCLUSION WITH 203 00:15:58,624 --> 00:16:07,533 OUTREACH EFFORTS. 204 00:16:07,533 --> 00:16:08,033 >> DEPUTY CHIEF FROM THE 205 00:16:08,033 --> 00:16:10,869 CHEROKEE NATION PARTICIPATING IN 206 00:16:10,869 --> 00:16:15,874 THE DAY 2 SESSION WITH THE 207 00:16:15,874 --> 00:16:18,277 LIAISON BETWEEN THE CHEROKEE 208 00:16:18,277 --> 00:16:24,316 NATION AND THE OUTREACH. 209 00:16:24,316 --> 00:16:24,917 AND THEN PATRICIA JONES GREAT 210 00:16:24,917 --> 00:16:28,587 CREDIT TO HER AND ALL THOSE WHO 211 00:16:28,587 --> 00:16:29,154 ARRANGED THE VISIT AND ALSO 212 00:16:29,154 --> 00:16:36,495 PLANNING FOR FUTURE VISITS AND 213 00:16:36,495 --> 00:16:37,496 WHERE THERE IS LESS 214 00:16:37,496 --> 00:16:45,904 OPPORTUNITY. 215 00:16:45,904 --> 00:16:46,438 AND THIS IS JUST PROGRESS 216 00:16:46,438 --> 00:16:47,039 DISSEMINATING WITH A LIST OF 217 00:16:47,039 --> 00:16:50,042 PRESS RELEASES AND ALL THOSE 218 00:16:50,042 --> 00:16:54,446 THAT HAVE PARTICIPATED. 219 00:16:54,446 --> 00:16:55,481 6 WITH CONGRESSIONAL BRIEFINGS 220 00:16:55,481 --> 00:17:04,490 AND STAFF. 221 00:17:04,490 --> 00:17:05,090 WE JUST WANT TO SHARE WITH YOU 222 00:17:05,090 --> 00:17:09,862 THIS IS THE 50th ANNIVERSARY 223 00:17:09,862 --> 00:17:12,498 WE INVITE YOU TO LEARN MORE 224 00:17:12,498 --> 00:17:17,302 ABOUT THE ACCOMPLISHMENTS TO 225 00:17:17,302 --> 00:17:18,303 CELEBRATE AND WE LOOK FORWARD TO 226 00:17:18,303 --> 00:17:28,814 OUR FUTURE AND THEN THE WAY TO 227 00:17:30,082 --> 00:17:40,459 SHARE IN YOUR CELEBRATION. 228 00:17:41,160 --> 00:17:42,127 HONORING SOME OF THE MANY 229 00:17:42,127 --> 00:17:44,797 SCIENTIST NIH WITH THE 230 00:17:44,797 --> 00:17:54,206 RECOGNITIONS OF THEIR WORK WITH 231 00:17:54,206 --> 00:17:55,641 THE BREAKTHROUGH PRIZE 232 00:17:55,641 --> 00:18:00,179 FOUNDATION FOR HIS WORK OVER THE 233 00:18:00,179 --> 00:18:10,689 GENERATION AND THEN ONCE AGAIN 234 00:18:13,559 --> 00:18:17,996 THIS YEAR GOING OVER THE COURSE 235 00:18:17,996 --> 00:18:21,099 OF THE MEETING WE WILL GO BACK 236 00:18:21,099 --> 00:18:24,770 TO IN PERSON BUT IT IS OPEN FOR 237 00:18:24,770 --> 00:18:35,013 REGISTRATION. 238 00:18:41,386 --> 00:18:44,456 THE COGNITIVE AGING SUMMIT IS 239 00:18:44,456 --> 00:18:50,529 COMING UP. 240 00:18:50,529 --> 00:18:51,563 AS IS THE RESEARCH SUMMIT IN 241 00:18:51,563 --> 00:18:58,937 SEPTEMBER. 242 00:18:58,937 --> 00:18:59,972 WE ARE ANNOUNCING WE HAVE A NEW 243 00:18:59,972 --> 00:19:03,976 NIH DIRECTOR. 244 00:19:03,976 --> 00:19:04,977 SHE'S ALREADY PROVEN TO BE AN 245 00:19:04,977 --> 00:19:14,052 OUTSTANDING LEADER. 246 00:19:14,052 --> 00:19:14,620 THE GUIDING PRINCIPLES TO BE 247 00:19:14,620 --> 00:19:16,688 SUMMARIZED HERE AND BULLETS THE 248 00:19:16,688 --> 00:19:19,224 PRIORITIES FOR HER ARE BRINGING 249 00:19:19,224 --> 00:19:23,562 TOGETHER RESEARCH DATA, BETTER 250 00:19:23,562 --> 00:19:25,631 HARMONIZATION AND COMMUNICATION 251 00:19:25,631 --> 00:19:31,637 ACROSS ALL DATABASES. 252 00:19:31,637 --> 00:19:32,671 AND THOSE BARRIERS TO 253 00:19:32,671 --> 00:19:42,915 PARTICIPATION. 254 00:19:43,148 --> 00:19:47,719 >> THE OTHER INTEREST IS IN THE 255 00:19:47,719 --> 00:19:50,689 ADVANCED RESEARCH AND NIH HAS 256 00:19:50,689 --> 00:19:52,791 BEEN A LEADER IN THIS RESEARCH 257 00:19:52,791 --> 00:19:56,795 AND WE ARE LOOKING FORWARD TO 258 00:19:56,795 --> 00:19:57,829 MONICA'S LEADERSHIP IN THIS 259 00:19:57,829 --> 00:20:05,671 AREA. 260 00:20:05,671 --> 00:20:11,243 WE ARE COMMITTED EVEN WITH THE 261 00:20:11,243 --> 00:20:14,546 FUNDS WE HAVE AND LOOKING FOR 262 00:20:14,546 --> 00:20:22,955 POTENTIAL NEW DISCOVERIES. 263 00:20:22,955 --> 00:20:23,588 AND ALSO RECENTLY AN APPOINTMENT 264 00:20:23,588 --> 00:20:24,456 LAST MONTH WITH THE NEW DIRECTOR 265 00:20:24,456 --> 00:20:26,491 OF NCI. 266 00:20:26,491 --> 00:20:31,496 FROM VANDERBILT UNIVERSITY AND 267 00:20:31,496 --> 00:20:35,467 WE LOOK FORWARD TO INTERACTIONS 268 00:20:35,467 --> 00:20:40,339 BETWEEN NCI AND AN IA. 269 00:20:40,339 --> 00:20:42,507 SIMILARLY WE HAVE A NEW NAME 270 00:20:42,507 --> 00:20:47,946 DIRECTOR OF AN A - - NIAID IN 271 00:20:47,946 --> 00:20:48,213 THE FALL. 272 00:20:48,213 --> 00:20:50,382 WORKING ACROSS HER RESEARCH AND 273 00:20:50,382 --> 00:20:52,217 EDUCATION AT A VERY COLLEGIATE 274 00:20:52,217 --> 00:20:58,156 LEVEL OF DIRECTORS. 275 00:20:58,156 --> 00:20:58,790 AND FINALLY WE ARE HAPPY TO ADD 276 00:20:58,790 --> 00:21:05,297 SOME STAFF UPDATES. 277 00:21:05,297 --> 00:21:08,367 MANY STAFF HAS JOINED US SINCE 278 00:21:08,367 --> 00:21:13,305 WE LAST SPOKE. 279 00:21:13,305 --> 00:21:13,839 THIS IS STARTING WITH BSR. 280 00:21:13,839 --> 00:21:15,207 >> WE ARE HAPPY TO INTRODUCE 5 281 00:21:15,207 --> 00:21:17,676 NEW STAFF MEMBERS THAT HAS 282 00:21:17,676 --> 00:21:28,020 JOINED US RECENTLY. 283 00:21:29,654 --> 00:21:30,122 FIRST OUR CLINICAL TRIALS 284 00:21:30,122 --> 00:21:30,689 COORDINATOR IN THE CLINICAL 285 00:21:30,689 --> 00:21:31,023 TRIALS OFFICE. 286 00:21:31,023 --> 00:21:31,656 JENNIFER IS PROVIDING OVERSIGHT 287 00:21:31,656 --> 00:21:32,324 OF THE CLINICAL TRIALS PORTFOLIO 288 00:21:32,324 --> 00:21:36,728 INCLUDING STEADY PROGRE 289 00:21:36,728 --> 00:21:37,329 PROGRESS, POPULATION DIVERSITY 290 00:21:37,329 --> 00:21:39,197 AND DATA AND SAFETY MONITORING. 291 00:21:39,197 --> 00:21:43,035 CONDUCT AND RISK ASSESSMENT. 292 00:21:43,035 --> 00:21:49,474 SHE IS A PHD IN COGNITIVE 293 00:21:49,474 --> 00:21:50,075 SCIENCE FROM THE UNIVERSITY OF 294 00:21:50,075 --> 00:21:50,876 ROCHESTER IN PRIOR TO JOINING US 295 00:21:50,876 --> 00:21:51,877 ASSISTANT PROFESSOR AT 296 00:21:51,877 --> 00:21:54,179 UNIVERSITY OF NEBRASKA MEDICAL 297 00:21:54,179 --> 00:21:58,583 CENTER LOOKING AT BEHAVIORAL 298 00:21:58,583 --> 00:22:01,720 DATA TALK ABOUT DEMENTIA AND 299 00:22:01,720 --> 00:22:07,626 AGING POPULATIONS. 300 00:22:07,626 --> 00:22:08,627 NEXT OFFICE OF DATA RESOURCES 301 00:22:08,627 --> 00:22:13,598 AND ANALYTICS REBECCA JOINED US 302 00:22:13,598 --> 00:22:14,633 AS A PROGRAM OFFICIAL AS A AAA 303 00:22:14,633 --> 00:22:22,641 AS POLICY FELLOW. 304 00:22:22,641 --> 00:22:23,041 ALSO LOOKING ON AI 305 00:22:23,041 --> 00:22:23,675 COLLABORATIONS, DATA SHARING AND 306 00:22:23,675 --> 00:22:26,945 PUBLIC/PRIVATE PARTNERSHIPS 307 00:22:26,945 --> 00:22:27,579 INCLUDING HOW RESEARCHERS CAN 308 00:22:27,579 --> 00:22:29,981 USE SOCIAL MEDIA AND 309 00:22:29,981 --> 00:22:31,450 PARTNERSHIPS TO RECRUIT 310 00:22:31,450 --> 00:22:35,554 PARTICIPANTS INTO RESEARCH. 311 00:22:35,554 --> 00:22:37,889 SHE IS A LEAD IN THE INTERNAL 312 00:22:37,889 --> 00:22:43,528 PROCESS TO SHARE WITH THE NIH 313 00:22:43,528 --> 00:22:43,795 POLICIES. 314 00:22:43,795 --> 00:22:47,466 PRIOR TO JOINING WITH THE 315 00:22:47,466 --> 00:22:57,976 POSTDOC TRAINING UNIVERSITY OF 316 00:22:58,210 --> 00:22:58,677 CAROLINA CHAPEL HILL AFTER 317 00:22:58,677 --> 00:22:59,311 EARNING PHD FROM THE UNIVERSITY 318 00:22:59,311 --> 00:22:59,611 OF MARYLAND. 319 00:22:59,611 --> 00:22:59,911 NEXT SLIDE. 320 00:22:59,911 --> 00:23:02,247 NEXT WE HAVE INDIVIDUAL 321 00:23:02,247 --> 00:23:04,616 PROCESSES BRANCH PROGRAM 322 00:23:04,616 --> 00:23:10,522 OFFICIAL MELISSA IS MANAGING BSR 323 00:23:10,522 --> 00:23:11,156 PORTFOLIO ON BEHAVIORAL 324 00:23:11,156 --> 00:23:12,791 INTERVENTION RESEARCH WHAT THE 325 00:23:12,791 --> 00:23:17,596 FOCUS ON CAREGIVING AND THOSE 326 00:23:17,596 --> 00:23:17,996 WHO CARE FOR THEM. 327 00:23:17,996 --> 00:23:21,099 JOINING US FROM AN IDC ARE. 328 00:23:21,099 --> 00:23:22,134 SHE COLLABORATES WITH HER OWN 329 00:23:22,134 --> 00:23:29,774 STAFF HERE AS WELL AS MULTIPLE 330 00:23:29,774 --> 00:23:33,044 INITIATIVES TO TAKE THIS 331 00:23:33,044 --> 00:23:34,179 APPROACH TO BEHAVIORAL 332 00:23:34,179 --> 00:23:43,255 INTERVENTION AND PRIOR TO THAT 333 00:23:43,255 --> 00:23:43,822 WORKING WITH DRUG ABUSE WITH 334 00:23:43,822 --> 00:23:44,322 CLINICAL PSYCHOLOGY FROM 335 00:23:44,322 --> 00:23:46,825 UNIVERSITY OF ARIZONA COMPLETING 336 00:23:46,825 --> 00:23:48,160 POSTDOC WORK AT UNIVERSITY OF 337 00:23:48,160 --> 00:23:52,731 PENNSYLVANIA. 338 00:23:52,731 --> 00:23:55,333 NEXT JOINING THIS MONTH OFFICE 339 00:23:55,333 --> 00:24:00,071 OF THE DIRECTOR TO OVERSEE THE 340 00:24:00,071 --> 00:24:01,072 TRAINING AND CAREER DEVELOPMENT 341 00:24:01,072 --> 00:24:03,775 PORTFOLIO ALSO CONTACT FOR SMALL 342 00:24:03,775 --> 00:24:08,980 BUSINESS ACTIVITIES WE ARE VERY 343 00:24:08,980 --> 00:24:10,448 HONORED TO BE RECRUITING HIM 344 00:24:10,448 --> 00:24:15,086 AFTER SEVERAL YEARS OF DIRECTING 345 00:24:15,086 --> 00:24:15,420 OUR TRAINING. 346 00:24:15,420 --> 00:24:17,155 HE WAS A SCIENTIFIC OFFICER 347 00:24:17,155 --> 00:24:20,392 PRIOR TO THIS AND THEN PRIOR TO 348 00:24:20,392 --> 00:24:23,261 THAT A RESEARCH FELLOW SO HE HAS 349 00:24:23,261 --> 00:24:27,666 A RICH BACKGROUND. 350 00:24:27,666 --> 00:24:30,202 HIS TRAINING IS MOLECULAR 351 00:24:30,202 --> 00:24:39,311 PHYSIOLOGY WITH HIS DEGREE FROM 352 00:24:39,311 --> 00:24:39,911 HANOVER IN GERMANY AND POSTDOC 353 00:24:39,911 --> 00:24:40,412 TRAINING IN PITTSBURGH. 354 00:24:40,412 --> 00:24:41,046 HE HAS A LONG-STANDING INTEREST 355 00:24:41,046 --> 00:24:42,714 IN SOCIAL SCIENCES RESEARCH WE 356 00:24:42,714 --> 00:24:43,748 ARE DELIGHTED TO GET HIM AND HIS 357 00:24:43,748 --> 00:24:46,518 EXPERTISE. 358 00:24:46,518 --> 00:24:49,854 AND JOINING OFFICE OF THE 359 00:24:49,854 --> 00:24:54,926 DIRECTOR FOR ES A WORKING WITH 360 00:24:54,926 --> 00:24:58,797 MEMBERS OF THE ADMIN TEAM AND IS 361 00:24:58,797 --> 00:25:03,468 HANDLING A VARIETY OF NEEDS. 362 00:25:03,468 --> 00:25:04,035 HE HAS A BACHELORS DEGREE IN 363 00:25:04,035 --> 00:25:06,471 HISTORY FROM UCLA COMES TO US 364 00:25:06,471 --> 00:25:09,507 WITH RICH EXPERIENCE INCLUDING 365 00:25:09,507 --> 00:25:18,149 SUPERVISORY ROLES SO JOIN ME TO 366 00:25:18,149 --> 00:25:18,683 WELCOME THE NEW BSR STAFF 367 00:25:18,683 --> 00:25:19,284 MEMBERS AND NOW I WILL TURN IT 368 00:25:19,284 --> 00:25:23,455 OVER. 369 00:25:23,455 --> 00:25:28,393 >> THE DIVISION OF AGING BIOLOGY 370 00:25:28,393 --> 00:25:29,027 WE HAVE 1 STAFF MEMBER WE WOULD 371 00:25:29,027 --> 00:25:31,863 LIKE TO WELCOME. 372 00:25:31,863 --> 00:25:35,900 KATHERINE KIM RECENTLY JOINED AS 373 00:25:35,900 --> 00:25:44,643 AND FTE AS SCIENTIFIC PROGRAM 374 00:25:44,643 --> 00:25:46,077 ANALYST SHE WAS A MASTER STUDENT 375 00:25:46,077 --> 00:25:49,314 AND UNIVERSITY OF MARYLAND. 376 00:25:49,314 --> 00:25:58,089 HER ROLE IS SHE MANAGES THE HBP 377 00:25:58,089 --> 00:25:58,590 PROGRAM AND SUPPORTS THE 378 00:25:58,590 --> 00:26:03,795 COORDINATION OF OTHER ACTIVITIES 379 00:26:03,795 --> 00:26:04,329 INCLUDING THE PROBLEMATIC 380 00:26:04,329 --> 00:26:05,063 ASPECTS AND HELPS US WITH THE 381 00:26:05,063 --> 00:26:09,534 GRANT CODING ASSIGNMENTS AND 382 00:26:09,534 --> 00:26:10,101 PROVIDES HELP WITH CLINICAL 383 00:26:10,101 --> 00:26:13,938 TRIAL OVERSIGHT AND SHE ALSO 384 00:26:13,938 --> 00:26:16,474 WORKS ON PORTFOLIO ANALYSIS 385 00:26:16,474 --> 00:26:17,776 GRANTS. 386 00:26:17,776 --> 00:26:21,112 WE WOULD LIKE TO WELCOME 387 00:26:21,112 --> 00:26:24,449 KATHERINE. 388 00:26:24,449 --> 00:26:32,657 >> HELLO. 389 00:26:32,657 --> 00:26:33,291 WE ARE PLEASED TO WELCOME SARAH 390 00:26:33,291 --> 00:26:35,293 CRAIG JOINING US AS A PROGRAM 391 00:26:35,293 --> 00:26:39,197 OFFICIAL AT THE CLINICAL 392 00:26:39,197 --> 00:26:39,631 GERONTOLOGY BRANCH. 393 00:26:39,631 --> 00:26:43,835 SHE WORKS WITH US AND DOING WORK 394 00:26:43,835 --> 00:26:52,610 THAT IS BEEN VERY USEFUL WITH 395 00:26:52,610 --> 00:27:01,720 THIS DUTIES OF LONGEVITY. 396 00:27:01,720 --> 00:27:04,356 [INAUDIBLE] 397 00:27:04,356 --> 00:27:08,259 SO WE ARE VERY GLAD SHE IS HERE. 398 00:27:08,259 --> 00:27:18,703 >> I AM HAPPY TO INTRODUCE 399 00:27:20,672 --> 00:27:21,106 SEVERAL NEW STAFF TO THE 400 00:27:21,106 --> 00:27:21,573 DIVISION OF EXTRAMURAL 401 00:27:21,573 --> 00:27:21,873 ACTIVITIES. 402 00:27:21,873 --> 00:27:22,941 WE ARE VERY FORTUNATE TO HAVE 403 00:27:22,941 --> 00:27:25,377 HIRED 5 NEW OUTSTANDING GRANTS 404 00:27:25,377 --> 00:27:30,882 MANAGEMENT SPECIALISTS INCLUDING 405 00:27:30,882 --> 00:27:31,916 TO THE CONTACTS MANAGEMENT 406 00:27:31,916 --> 00:27:35,387 BRANCH. 407 00:27:35,387 --> 00:27:43,161 MS. BEAN JOINS US FROM US 408 00:27:43,161 --> 00:27:43,428 FERTILITY. 409 00:27:43,428 --> 00:27:46,631 AUSTIN JOINS US FROM THE 410 00:27:46,631 --> 00:27:47,499 ADMINISTRATIVE SUPPORT 411 00:27:47,499 --> 00:27:50,502 SPECIALIST POSITION FROM 412 00:27:50,502 --> 00:27:55,673 DEPARTMENT OF ENERGY. 413 00:27:55,673 --> 00:28:00,445 MORGAN JOINS US AS A FORMER 414 00:28:00,445 --> 00:28:03,381 PROGRAM COORDINATOR FROM 415 00:28:03,381 --> 00:28:13,792 FREDERICK NATIONAL LAB. 416 00:28:16,728 --> 00:28:17,162 AND NEXT JOINING US FROM 417 00:28:17,162 --> 00:28:17,729 EXECUTIVE CUSTOMER RELATIONS 418 00:28:17,729 --> 00:28:18,263 POSITION WITH AMAZON AS A 419 00:28:18,263 --> 00:28:18,696 FINANCIAL MANAGEMENT 420 00:28:18,696 --> 00:28:19,330 ANALYST, MS. MCLEOD AND THEN WE 421 00:28:19,330 --> 00:28:23,735 HAVE ANNA JOINING US AS A FORMER 422 00:28:23,735 --> 00:28:27,739 TEACHER. 423 00:28:27,739 --> 00:28:28,306 WE ARE VERY FORTUNATE TO GET 424 00:28:28,306 --> 00:28:31,576 THESE 5 NEW MEMBERS INTO THE 425 00:28:31,576 --> 00:28:35,413 GRANTS MANAGEMENT PROGRAM. 426 00:28:35,413 --> 00:28:41,786 NEXT WE HAVE OFFICE OF CLINICAL 427 00:28:41,786 --> 00:28:42,520 RESEARCH WE HAVE RECENTLY HIRED 428 00:28:42,520 --> 00:28:44,322 MICHELLE SNYDER. 429 00:28:44,322 --> 00:28:48,693 WE WELCOME HER AS A REGULATORY 430 00:28:48,693 --> 00:28:52,030 POLICY SPECIALIST WORKING ON 431 00:28:52,030 --> 00:28:57,268 POLICIES AND PROCEDURES IN THE 432 00:28:57,268 --> 00:29:07,812 CLINICAL SUPPORT CONTRACT SHE IS 433 00:29:18,256 --> 00:29:18,823 A CERTIFIED PROJECT MANAGER AND 434 00:29:18,823 --> 00:29:19,390 A GENETIC COUNSELOR WITH 16 435 00:29:19,390 --> 00:29:20,024 YEARS OF GENETICS AND MANAGEMENT 436 00:29:20,024 --> 00:29:20,625 HEALTH COMMUNICATIONS WEBSITE 437 00:29:20,625 --> 00:29:21,226 CONTENT STRATEGY AND BUSINESS 438 00:29:21,226 --> 00:29:21,659 PROCESS IMPROVEMENT. 439 00:29:21,659 --> 00:29:22,227 SHE RECEIVED HER MASTERS IN 440 00:29:22,227 --> 00:29:27,298 GENETIC COUNSELING AND HAS A BS 441 00:29:27,298 --> 00:29:27,799 IN BIOLOGY FROM CORNELL. 442 00:29:27,799 --> 00:29:34,873 SHE PREVIOUSLY SERVED WITHIN THE 443 00:29:34,873 --> 00:29:38,443 DEA OFFICE AND WAS INSTRUMENTAL 444 00:29:38,443 --> 00:29:39,611 TO DEVELOP POLICIES AND 445 00:29:39,611 --> 00:29:43,882 PROCEDURES AND PUBLISHING OUR 446 00:29:43,882 --> 00:29:47,185 INTERNAL LAB MATERIAL. 447 00:29:47,185 --> 00:29:57,695 NEXT WE HAVE HIRES WITHIN THE 448 00:29:58,429 --> 00:29:58,963 OFFICE OF STRATEGIC EXTRAMURAL 449 00:29:58,963 --> 00:30:03,034 PROGRAMS. 450 00:30:03,034 --> 00:30:06,304 FIRST YOU PROBABLY KNOW TODD BUT 451 00:30:06,304 --> 00:30:12,243 NOW HAS A NEW ROLE AS SENIOR 452 00:30:12,243 --> 00:30:19,250 ADVISOR ON BIOMEDICAL INNOVA 453 00:30:19,250 --> 00:30:19,551 INNOVATION. 454 00:30:19,551 --> 00:30:20,151 HE WILL DEVELOP STRATEGIES FOR 455 00:30:20,151 --> 00:30:20,718 TARGETED BIOMEDICAL PRODUCT 456 00:30:20,718 --> 00:30:24,088 ASSESSMENT INVESTMENTS ALIGNED 457 00:30:24,088 --> 00:30:30,929 WITH THE NIA MISSION AND ALSO 458 00:30:30,929 --> 00:30:31,496 HAS A ROLE OF THE OFFICE OF 459 00:30:31,496 --> 00:30:33,531 STRATEGIC EXTRAMURAL PROGRAM 460 00:30:33,531 --> 00:30:36,834 DIRECTOR AND THEN TO BE FOCUS ON 461 00:30:36,834 --> 00:30:39,637 TRAINING AND DEVELOPMENT AND 462 00:30:39,637 --> 00:30:40,672 SMALL BUSINESS RESEARCH 463 00:30:40,672 --> 00:30:43,641 PROGRAMS. 464 00:30:43,641 --> 00:30:48,413 TODD HAS A PHD FROM EINSTEIN 465 00:30:48,413 --> 00:30:49,013 COLLEGE OF SCHOOL OF MEDICINE 466 00:30:49,013 --> 00:30:52,283 WITH A CERTIFICATE OF TECHNOLOGY 467 00:30:52,283 --> 00:30:53,117 FROM JOHNS HOPKINS BUSINESS 468 00:30:53,117 --> 00:30:56,187 SCHOOL. 469 00:30:56,187 --> 00:30:56,754 HE ALSO COMPLETED A POSTDOC 470 00:30:56,754 --> 00:31:00,792 FELLOWSHIP AT PFIZER. 471 00:31:00,792 --> 00:31:02,260 LEADING THE RESEARCH EFFORTS IN 472 00:31:02,260 --> 00:31:06,164 COLLABORATION WITH WASHINGTON 473 00:31:06,164 --> 00:31:09,367 SCHOOL UNIVERSITY OF MEDICINE. 474 00:31:09,367 --> 00:31:09,968 RECEIVING SEVERAL PRESTIGIOUS 475 00:31:09,968 --> 00:31:12,503 AWARDS AND HONORS INCLUDING THE 476 00:31:12,503 --> 00:31:16,274 NCI LEADERSHIP DEVELOPMENT AWARD 477 00:31:16,274 --> 00:31:19,877 SEVERAL DIRECTORS OF WORDS AND 478 00:31:19,877 --> 00:31:26,417 ALSO VOLUNTEERS. 479 00:31:26,417 --> 00:31:27,085 WE ARE FORTUNATE TO CONTINUE TO 480 00:31:27,085 --> 00:31:27,685 HAVE TODD IN HIS CAPACITY AS A 481 00:31:27,685 --> 00:31:32,357 SENIOR ADVISOR ON BIOMEDICAL 482 00:31:32,357 --> 00:31:32,657 INNOVATION. 483 00:31:32,657 --> 00:31:34,759 AND THEN WE HAVE DOCTOR LAURA 484 00:31:34,759 --> 00:31:39,230 MAJOR 1 OF OUR NEW TRAINING 485 00:31:39,230 --> 00:31:47,639 OFFICERS SHE WILL ASSIST CAREER 486 00:31:47,639 --> 00:31:48,339 DEVELOPMENT APPLICANTS AND 487 00:31:48,339 --> 00:31:53,077 DEVELOP TRAINING AND FUNDING 488 00:31:53,077 --> 00:31:53,678 OPPORTUNITIES AND INITIATIVES 489 00:31:53,678 --> 00:31:56,347 AND COMMUNICATION MATERIALS. 490 00:31:56,347 --> 00:31:59,951 CHOSE TO CONDUCT ANALYSIS WITH 491 00:31:59,951 --> 00:32:02,420 OPPORTUNITIES WITH NIH FUNDING 492 00:32:02,420 --> 00:32:07,925 WITHIN THE PROGRAM. 493 00:32:07,925 --> 00:32:10,495 PRIOR TO JOINING OS EPA PROGRAM 494 00:32:10,495 --> 00:32:14,832 OFFICER WITH BEHAVIORAL AND 495 00:32:14,832 --> 00:32:15,433 SOCIAL RESEARCH AND MANAGED TO 496 00:32:15,433 --> 00:32:15,967 GRANT PORTFOLIO FOCUSED ON 497 00:32:15,967 --> 00:32:22,573 INSTITUTIONAL TRAINING. 498 00:32:22,573 --> 00:32:23,074 SHE HAS HER DOCTORATE IN 499 00:32:23,074 --> 00:32:26,077 PHILOSOPHY AND HEALTH BEHAVIOR 500 00:32:26,077 --> 00:32:27,612 FROM GEORGE WASHINGTON 501 00:32:27,612 --> 00:32:34,052 UNIVERSITY. 502 00:32:34,052 --> 00:32:44,595 >> GOOD MORNING I AM PLEASED TO 503 00:32:44,962 --> 00:32:45,496 ANNOUNCE THE NEW STAFF OF THE 504 00:32:45,496 --> 00:32:45,997 OFFICE OF ADMINISTRATIVE 505 00:32:45,997 --> 00:32:46,297 MANAGEMENT. 506 00:32:46,297 --> 00:32:46,864 FIRST I WILL START WITH THE 507 00:32:46,864 --> 00:32:50,401 FINANCIAL MANAGEMENT BRANCH. 508 00:32:50,401 --> 00:32:50,968 WE ARE PLEASED TO INTRODUCE 509 00:32:50,968 --> 00:32:51,469 CINDY HENDRICKSON A NEW 510 00:32:51,469 --> 00:32:56,174 SUPERVISORY BUDGET ANALYST. 511 00:32:56,174 --> 00:32:56,741 HER EXPERTISE IS IN LEADING 512 00:32:56,741 --> 00:32:57,241 BUDGET FORMULATION AND 513 00:32:57,241 --> 00:32:59,343 EXECUTION. 514 00:32:59,343 --> 00:33:03,915 SHE COMES FROM THE NIH CENTER 515 00:33:03,915 --> 00:33:04,549 FOR INFORMATION TECHNOLOGY IS A 516 00:33:04,549 --> 00:33:14,826 BUDGET ANALYST. 517 00:33:15,893 --> 00:33:16,461 OUR WORKFORCE AND ADMINISTRATIVE 518 00:33:16,461 --> 00:33:17,061 MANAGEMENT BRANCH HAS HIRED A 519 00:33:17,061 --> 00:33:17,328 FEW STAFF. 520 00:33:17,328 --> 00:33:17,862 FIRST HANNAH COOPER A NEW 521 00:33:17,862 --> 00:33:25,503 PROGRAM SPECIALIST WORKING ON 522 00:33:25,503 --> 00:33:26,070 OPTIMIZING THE WORKFORCE AND 523 00:33:26,070 --> 00:33:26,537 ADMINISTRATIVE BRANCH 524 00:33:26,537 --> 00:33:26,838 PERFORMANCE. 525 00:33:26,838 --> 00:33:27,872 HER BACKGROUND IS HR SPECIALIST 526 00:33:27,872 --> 00:33:33,144 WITH THE USAF AND ANOTHER NEW 527 00:33:33,144 --> 00:33:43,688 SENIOR ADVISOR IS MARLENE GUZMAN 528 00:33:44,322 --> 00:33:44,856 OFFICE OF STRATEGIC WORKFORCE 529 00:33:44,856 --> 00:33:45,123 PLANNING. 530 00:33:45,123 --> 00:33:45,757 SHE PREVIOUSLY SERVED AS ADVISOR 531 00:33:45,757 --> 00:33:50,528 AND CONTRACTOR IN OAM AND 532 00:33:50,528 --> 00:33:51,062 RECENTLY CONVERTED TO FTE 533 00:33:51,062 --> 00:33:56,467 FEDERAL EMPLOYEE. 534 00:33:56,467 --> 00:34:06,410 AND LASTLY RECENT HIGHER CAMERA 535 00:34:06,410 --> 00:34:07,044 AND MORE A NEW PATHWAYS STUDENT 536 00:34:07,044 --> 00:34:07,278 INTERN. 537 00:34:07,278 --> 00:34:07,845 HE HAS HR EXPERTISE AND WILL 538 00:34:07,845 --> 00:34:08,780 WORK CLOSELY WITH HR LIAISON 539 00:34:08,780 --> 00:34:14,118 TEAM AND JOINS US FROM HR 540 00:34:14,118 --> 00:34:19,257 ASSAY. 541 00:34:19,257 --> 00:34:24,996 >> GOOD MORNING I AM PLEASED TO 542 00:34:24,996 --> 00:34:28,800 ANNOUNCE 2 NEW STAFF HIRES IN 543 00:34:28,800 --> 00:34:29,367 THE OFFICE OF THE ASSOCIATE 544 00:34:29,367 --> 00:34:29,967 DIRECTOR IT'S A NEW OFFICE IN 545 00:34:29,967 --> 00:34:33,037 THE LAST YEAR INTRODUCING 546 00:34:33,037 --> 00:34:36,340 OVERSEAS LEGISLATION POLICY AS 547 00:34:36,340 --> 00:34:36,908 WELL AS STRATEGIC PLANNING. 548 00:34:36,908 --> 00:34:41,579 I AM PLEASED TO ANNOUNCE SHALL 549 00:34:41,579 --> 00:34:44,649 BE -- -- MS. SMITH COORDINATE 550 00:34:44,649 --> 00:34:47,418 AND ASSIST PROJECTS AND COMING 551 00:34:47,418 --> 00:34:50,054 TO US FROM THE COMMUNICATIONS 552 00:34:50,054 --> 00:34:54,592 BUT PREVIOUSLY WORKING WITH 553 00:34:54,592 --> 00:35:00,731 STRATEGIC INDICATIONS AND PUBLIC 554 00:35:00,731 --> 00:35:01,365 RELATIONS AND WILL BE DOING VERY 555 00:35:01,365 --> 00:35:05,136 SIMILAR WORK FOR US AS WELL AND 556 00:35:05,136 --> 00:35:11,242 ALSO THE PROGRAM 557 00:35:11,242 --> 00:35:11,843 SPECIALIST, DAVID COMES US TO 558 00:35:11,843 --> 00:35:12,410 THE DEPARTMENT OF AGING AND 559 00:35:12,410 --> 00:35:14,545 DISABILITIES AND ORGANIZING THE 560 00:35:14,545 --> 00:35:16,047 TOWN HALL MEETINGS AND 561 00:35:16,047 --> 00:35:19,217 ENGAGEMENT AND PROJECTS UNDER MY 562 00:35:19,217 --> 00:35:23,020 DIRECTION AS WELL AS SHELBY. 563 00:35:23,020 --> 00:35:30,127 BEFORE I TURN IT OVER I WENT TO 564 00:35:30,127 --> 00:35:32,563 INTRODUCE COURTNEY AS A NEW 565 00:35:32,563 --> 00:35:33,297 DIRECTOR OF OFFICE OF 566 00:35:33,297 --> 00:35:35,900 LEGISLATION AND POLICY. 567 00:35:35,900 --> 00:35:37,668 SHE WAS RECENTLY PROMOTED TO 568 00:35:37,668 --> 00:35:41,973 THIS POSITION FROM DEPUTY 569 00:35:41,973 --> 00:35:44,242 DIRECTOR. 570 00:35:44,242 --> 00:35:48,512 SHE HAS BEEN WITH NIH SINCE 2016 571 00:35:48,512 --> 00:35:49,413 STARTING AS A PRESIDENT 572 00:35:49,413 --> 00:35:56,153 MANAGEMENT FELLOW AND ALSO HAS 573 00:35:56,153 --> 00:35:57,054 WORKED AS THE OUTREACH LEAD FOR 574 00:35:57,054 --> 00:35:59,991 SOME TIME. 575 00:35:59,991 --> 00:36:00,591 WE ARE PLEASED TO HAVE HER ON 576 00:36:00,591 --> 00:36:05,696 BOARD AS THE NEW OPM DIRECTOR. 577 00:36:05,696 --> 00:36:08,099 >> THANK YOU. 578 00:36:08,099 --> 00:36:14,906 I'M HAPPY TO WELCOME MEGAN 579 00:36:14,906 --> 00:36:15,439 MILLER A NEUROBIOLOGIST BY 580 00:36:15,439 --> 00:36:15,940 TRAINING WORKING AT THE 581 00:36:15,940 --> 00:36:16,507 INTERSECTION OF SCIENCE AND 582 00:36:16,507 --> 00:36:22,613 POLICY FOR SEVERAL YEARS. 583 00:36:22,613 --> 00:36:23,247 SHE HAS EXPERIENCE IN PUBLIC AND 584 00:36:23,247 --> 00:36:23,681 NONPROFIT SETTINGS. 585 00:36:23,681 --> 00:36:32,056 BS IN BIOLOGY AND MICROBIOLOGY. 586 00:36:32,056 --> 00:36:32,690 PHD IN BIOMEDICAL SCIENCES FROM 587 00:36:32,690 --> 00:36:33,291 THE UNIVERSITY OF CONNECTICUT 588 00:36:33,291 --> 00:36:33,891 AND A GRADUATE CERTIFICATE OF 589 00:36:33,891 --> 00:36:42,266 PUBLIC LEADERSHIP AND MANAGEMENT 590 00:36:42,266 --> 00:36:42,833 FROM YUKON SCHOOL OF PUBLIC 591 00:36:42,833 --> 00:36:43,067 POLICY. 592 00:36:43,067 --> 00:36:43,668 SHE COMPLETED NIH POSTDOCTORAL 593 00:36:43,668 --> 00:36:44,235 FELLOWSHIP AT YALE SCHOOL OF 594 00:36:44,235 --> 00:36:45,903 MEDICINE AND TRIPLE A POLICY 595 00:36:45,903 --> 00:36:46,203 FELLOWSHIP. 596 00:36:46,203 --> 00:36:51,776 SHE WILL BE CO- LEADING EFFORTS 597 00:36:51,776 --> 00:36:52,276 AROUND THE INTERNATIONAL 598 00:36:52,276 --> 00:36:53,010 ACTIVITIES AS WELL AS SUPPORTING 599 00:36:53,010 --> 00:36:53,644 CONGRESSIONAL AND OTHER EXTERNAL 600 00:36:53,644 --> 00:36:55,479 ENGAGEMENTS. 601 00:36:55,479 --> 00:37:05,957 WE ARE HAPPY TO WELCOME HER. 602 00:37:11,362 --> 00:37:11,662 >> GOOD MORNING. 603 00:37:11,662 --> 00:37:12,263 I AM DIRECTOR OF THE OFFICE OF 604 00:37:12,263 --> 00:37:12,797 COMMUNICATIONS AND PUBLIC 605 00:37:12,797 --> 00:37:13,164 LIAISON AT NIA. 606 00:37:13,164 --> 00:37:14,498 I AM PLEASED TO ANNOUNCE OUR 607 00:37:14,498 --> 00:37:17,068 STUDENT TRAINEE WITH 608 00:37:17,068 --> 00:37:19,971 ADMINISTRATIVE SUPPORT WORKING 609 00:37:19,971 --> 00:37:25,042 ON SEVERAL PROJECTS INCLUDING 610 00:37:25,042 --> 00:37:33,484 SOME PUBLIC ANALYSIS AND HEALTH 611 00:37:33,484 --> 00:37:34,051 ATTIC - - EQUITY AND HEALTH 612 00:37:34,051 --> 00:37:34,685 LITERACY AUDIT AND ACCESSIBILITY 613 00:37:34,685 --> 00:37:35,019 IMPROVEMENTS. 614 00:37:35,019 --> 00:37:35,619 JOINING US FROM THE NATIONAL 615 00:37:35,619 --> 00:37:36,320 HEART AND BLOOD INSTITUTE. 616 00:37:36,320 --> 00:37:44,895 WELCOME. 617 00:37:44,895 --> 00:37:53,304 >> I AM PLEASED TO TELL YOU 618 00:37:53,304 --> 00:37:56,907 ABOUT THE NEW HIRES IN HER 619 00:37:56,907 --> 00:38:01,278 FAMILY. 620 00:38:01,278 --> 00:38:07,718 FROM THE ADMINISTRATIVE OFFICER 621 00:38:07,718 --> 00:38:08,319 WITH PROCUREMENT AND OUTREACH 622 00:38:08,319 --> 00:38:08,919 AND TRAINING AND JOINS US FROM 623 00:38:08,919 --> 00:38:09,453 THE DEPARTMENT OF VETERAN 624 00:38:09,453 --> 00:38:14,525 AFFAIRS. 625 00:38:14,525 --> 00:38:15,092 NEXT HOUR PROGRAM SPECIALIST 626 00:38:15,092 --> 00:38:15,659 ASSIST WITH RECRUITMENT AND 627 00:38:15,659 --> 00:38:20,398 STRATEGIC PLANNING AND WITH THE 628 00:38:20,398 --> 00:38:22,033 EXPANSION AND JOINS US FROM V.A. 629 00:38:22,033 --> 00:38:32,510 MARYLAND HEALTHCARE SYSTEM. 630 00:38:36,814 --> 00:38:37,248 AND UP NEXT OUR PROGRAM 631 00:38:37,248 --> 00:38:37,815 SPECIALIST COORDINATING IRP 632 00:38:37,815 --> 00:38:41,719 PERFORMANCE OF WORDS AND MANY 633 00:38:41,719 --> 00:38:49,060 OTHER MEN JOINING US FROM THE 634 00:38:49,060 --> 00:38:53,731 NIH OFFICE. 635 00:38:53,731 --> 00:38:54,765 WITH A PROFIT MANAGEMENT 636 00:38:54,765 --> 00:39:04,975 SPECIALIST. 637 00:39:08,746 --> 00:39:14,952 AND THEN WE HAVE THE MEMBER AT 638 00:39:14,952 --> 00:39:15,386 NETWORKING COMMUNITY 639 00:39:15,386 --> 00:39:17,855 TECHNOLOGIES SECTION. 640 00:39:17,855 --> 00:39:22,460 AS AN IT SPECIALIST SHE WILL 641 00:39:22,460 --> 00:39:23,861 OVERSEE AND COORDINATE SUPPORT 642 00:39:23,861 --> 00:39:28,232 ACTIVITIES, ESPECIALLY 643 00:39:28,232 --> 00:39:30,267 ESCALATING EMERGENCIES TO THE 644 00:39:30,267 --> 00:39:35,906 HELP DESK AND MANAGES THE 645 00:39:35,906 --> 00:39:44,315 APPLICATIONS FOR THE MAC SYST 646 00:39:44,315 --> 00:39:44,548 SYSTEMS. 647 00:39:44,548 --> 00:39:46,684 PREVIOUSLY AND A CONTRACTING 648 00:39:46,684 --> 00:39:53,891 POSITION FOR NIA. 649 00:39:53,891 --> 00:39:54,425 NEXT, RICK WORDS IS THE IT 650 00:39:54,425 --> 00:39:55,025 SPECIALIST SUPPORTING THE DATA 651 00:39:55,025 --> 00:39:56,560 CENTER AND INFRASTRUCTURE 652 00:39:56,560 --> 00:39:57,595 EFFORTS. 653 00:39:57,595 --> 00:40:00,364 JOINING US FROM THE USAF LEGAL 654 00:40:00,364 --> 00:40:04,869 INFORMATION SERVICES. 655 00:40:04,869 --> 00:40:08,873 WE HAVE A BIOLOGIST GENE 656 00:40:08,873 --> 00:40:10,941 REGULATION SECTION. 657 00:40:10,941 --> 00:40:18,716 SHE CONDUCTS RESEARCH AROUND THE 658 00:40:18,716 --> 00:40:19,216 MOLECULAR MECHANISMS AND 659 00:40:19,216 --> 00:40:21,719 PROCESSES THAT CONTRIBUTE TO AGE 660 00:40:21,719 --> 00:40:22,753 ASSOCIATED CHANGES IN PHYSIOLOGY 661 00:40:22,753 --> 00:40:29,527 INCLUDING DISEASES HIS 662 00:40:29,527 --> 00:40:30,161 PREVALENCE INCREASE WITH AGE AND 663 00:40:30,161 --> 00:40:30,761 HAS BEEN A CONTRACTOR WITH NIA 664 00:40:30,761 --> 00:40:34,899 SINCE 2015. 665 00:40:34,899 --> 00:40:37,501 NEXT GORDON THOMPSON PROGRAM 666 00:40:37,501 --> 00:40:42,339 SUPPORT ASSISTANT COORDINATES 667 00:40:42,339 --> 00:40:42,940 EFFORT FOR TRAVEL PURCHASING A 668 00:40:42,940 --> 00:40:44,875 NEW HIRE AND WAS A CONTRACTOR 669 00:40:44,875 --> 00:40:55,186 POSITION WITH NIA. 670 00:40:55,953 --> 00:41:01,058 AND NEXT WE HAVE A BIOLOGIST WHO 671 00:41:01,058 --> 00:41:02,459 LEVERAGES EXPERTISE IN LONG WE 672 00:41:02,459 --> 00:41:07,097 SEQUENCING AND JOINING US FROM 673 00:41:07,097 --> 00:41:11,101 LAB TECH CONTRACTING POSITION 674 00:41:11,101 --> 00:41:11,835 FOR NIH. 675 00:41:11,835 --> 00:41:14,338 UP NEXT TENURE-TRACK 676 00:41:14,338 --> 00:41:16,440 INVESTIGATOR FROM THE MOLECULAR 677 00:41:16,440 --> 00:41:21,879 AND PATHOLOGY UNIT. 678 00:41:21,879 --> 00:41:24,448 SHE USES MULTI- ONYX TECHNIQUES 679 00:41:24,448 --> 00:41:28,419 TO UNRAVEL THE UNDERLYING 680 00:41:28,419 --> 00:41:31,889 DISEASES AND DEMENTIA. 681 00:41:31,889 --> 00:41:40,464 COMING FROM UC SAN FRANCISCO. 682 00:41:40,464 --> 00:41:45,836 >> THANK YOU FOR THAT IMPRESSIVE 683 00:41:45,836 --> 00:41:46,337 PRESENTATION AND ALL THE 684 00:41:46,337 --> 00:41:48,973 WONDERFUL NEW TALENT. 685 00:41:48,973 --> 00:41:56,280 JUST AS A REMINDER TO ALL OF YOU 686 00:41:56,280 --> 00:41:56,880 KEEP INFORMED WHAT'S GOING ON 687 00:41:56,880 --> 00:42:01,118 THROUGH THE VARIOUS LINKS. 688 00:42:01,118 --> 00:42:01,719 THANK YOU AND NOW WE WILL OPEN 689 00:42:01,719 --> 00:42:05,856 FOR DISCUSSION FOR ANYTHING YOU 690 00:42:05,856 --> 00:42:10,227 HAVEN'T HEARD OVER THE PAST 40 691 00:42:10,227 --> 00:42:14,098 MINUTES. 692 00:42:14,098 --> 00:42:24,575 CONVERSATIONS OR QUESTIONS? 693 00:42:29,013 --> 00:42:38,522 >> I HAVE A COMMENT. 694 00:42:38,522 --> 00:42:39,123 I WANT TO DO THINK THE ENTIRE 695 00:42:39,123 --> 00:42:39,690 TEAM FOR MAKING THE TRIP TO 696 00:42:39,690 --> 00:42:41,158 INDIAN COUNTRY AT CHEROKEE 697 00:42:41,158 --> 00:42:41,458 NATION. 698 00:42:41,458 --> 00:42:48,432 WANT TO TELL EVERYBODY THAT THE 699 00:42:48,432 --> 00:42:48,999 TEAM WAS THE FIRST 1 EVER TO 700 00:42:48,999 --> 00:42:51,435 COME TO CHEROKEE NATION AND HAD 701 00:42:51,435 --> 00:42:53,971 A FIRSTHAND OPPORTUNITY. 702 00:42:53,971 --> 00:42:59,777 THEY WERE EXTREMELY THRILLED AND 703 00:42:59,777 --> 00:43:05,316 I WISH MORE NIH LEADERS TAKE THE 704 00:43:05,316 --> 00:43:05,816 TIME TO COME AND SEE FOR 705 00:43:05,816 --> 00:43:06,383 THEMSELVES WHAT THE CHEROKEE 706 00:43:06,383 --> 00:43:10,254 INDIAN PEOPLE ARE DOING WITH 707 00:43:10,254 --> 00:43:10,821 VERY VERY LIMITED RESOURCES. 708 00:43:10,821 --> 00:43:13,357 I WANT TO THANK EVERYBODY FOR 709 00:43:13,357 --> 00:43:21,899 MAKING IT HAPPEN. 710 00:43:21,899 --> 00:43:22,466 >> THANK YOU FOR HELPING TO 711 00:43:22,466 --> 00:43:22,833 FACILITATE THAT. 712 00:43:22,833 --> 00:43:23,334 IT WAS AN EXTRAORDINARY 713 00:43:23,334 --> 00:43:23,634 EXPERIENCE. 714 00:43:23,634 --> 00:43:24,234 ANYONE WHO HAS AN OPPORTUNITY 715 00:43:24,234 --> 00:43:28,839 SHOULD TAKE ADVANTAGE OF IT. 716 00:43:28,839 --> 00:43:29,373 AND I HAVE SHARED WITH MY 717 00:43:29,373 --> 00:43:29,840 COLLEAGUE LEADERSHIP. 718 00:43:29,840 --> 00:43:30,474 WE WILL SEE WHAT COMES FROM 719 00:43:30,474 --> 00:43:40,584 THIS. 720 00:43:41,685 --> 00:43:42,252 ALSO DOING IF YOU HAVE THOUGHTS 721 00:43:42,252 --> 00:43:44,254 ABOUT GEOGRAPHIC 722 00:43:44,254 --> 00:43:47,791 AREAS, LOCATIONS WHERE THERE HAS 723 00:43:47,791 --> 00:43:51,195 BEEN UNDER OPPORTUNITY TO 724 00:43:51,195 --> 00:43:52,763 INTERACT CLICKS IF YOU HAVE 725 00:43:52,763 --> 00:43:56,834 SUGGESTIONS. 726 00:43:56,834 --> 00:43:58,902 OFTEN AS A HOSTING INSTITUTION 727 00:43:58,902 --> 00:44:02,940 HAVE A RESEARCH PRESENCE BUT 728 00:44:02,940 --> 00:44:03,440 ALSO AS AN ORGANIZER FOR 729 00:44:03,440 --> 00:44:07,044 MULTIPLE INSTITUTIONS SO WE ARE 730 00:44:07,044 --> 00:44:13,550 OPEN TO SUGGESTIONS. 731 00:44:13,550 --> 00:44:14,118 >> GUY WORD MENTION THE HARD 732 00:44:14,118 --> 00:44:16,887 WORK BY A DOCTOR JONES AND HER 733 00:44:16,887 --> 00:44:27,331 TEAM TO MAKE THIS HAPPEN. 734 00:44:30,000 --> 00:44:36,874 >> 2 THINGS COMING ACROSS FROM 735 00:44:36,874 --> 00:44:38,575 THE PRESENTATION AT A HIGH LEVEL 736 00:44:38,575 --> 00:44:44,882 HOW MANY DIFFERENT CREATIVE 737 00:44:44,882 --> 00:44:47,284 APPROACHES AND IA HAS PUT 738 00:44:47,284 --> 00:44:51,855 TOGETHER? 739 00:44:51,855 --> 00:44:52,456 I THINK THAT IS IMPRESSIVE AND 740 00:44:52,456 --> 00:45:02,566 THE OPPORTUNITIES FOR FEEDBACK 741 00:45:02,566 --> 00:45:03,133 IT JUST SEEMS TO HAVE A WIDE 742 00:45:03,133 --> 00:45:09,273 RANGE OF IDEAS AND THAT'S ALSO 743 00:45:09,273 --> 00:45:11,074 APPRECIATED WE APPRECIATE THOSE 744 00:45:11,074 --> 00:45:18,549 2 PRINCIPLES. 745 00:45:18,549 --> 00:45:27,624 >> BEFORE I COMMENT I SAW 746 00:45:27,624 --> 00:45:29,092 SOMEONE HAD THEIR HAND UP ASKING 747 00:45:29,092 --> 00:45:36,834 FOR SUGGESTIONS WHERE NIH COULD 748 00:45:36,834 --> 00:45:37,301 VISIT I HAVE LESS OF A 749 00:45:37,301 --> 00:45:37,935 SUGGESTION OF A PLACE THAT MORE 750 00:45:37,935 --> 00:45:43,340 OF A SUGGESTION OF AROUND THE 751 00:45:43,340 --> 00:45:43,574 VISITS. 752 00:45:43,574 --> 00:45:50,314 WE HEARD YESTERDAY FROM THE 753 00:45:50,314 --> 00:45:50,914 COMMUNITY COLLEGES TO RECRUIT 754 00:45:50,914 --> 00:45:51,782 THE NEXT GENERATION OF AGING 755 00:45:51,782 --> 00:45:55,319 RESEARCHERS AND I CAN IMAGINE 756 00:45:55,319 --> 00:46:00,424 BUT A POWERFUL THING IT WOULD BE 757 00:46:00,424 --> 00:46:01,058 TO HAVE A CONTINGENT THAT WE SAW 758 00:46:01,058 --> 00:46:07,364 ON THE PICTURE TAKING PART IN AN 759 00:46:07,364 --> 00:46:12,870 AGING AND RESEARCH DAY AT A 760 00:46:12,870 --> 00:46:13,837 BUNCH OF COMMUNITY COLLEGES IN 761 00:46:13,837 --> 00:46:19,343 AN AREA MAYBE THAT COULD BE 762 00:46:19,343 --> 00:46:21,578 TIMED WITH OTHER LEADERS GOING 763 00:46:21,578 --> 00:46:31,989 ON THAT COULD BE IN TOWN 764 00:46:33,190 --> 00:46:33,657 PHILADELPHIA IN JULY IS AN 765 00:46:33,657 --> 00:46:35,692 EXAMPLE. 766 00:46:35,692 --> 00:46:40,731 BUT THAT IS POTENTIALLY A VERY 767 00:46:40,731 --> 00:46:45,168 INSPIRING AND POWERFUL TYPE OF 768 00:46:45,168 --> 00:46:53,610 VISIT. 769 00:46:53,610 --> 00:46:54,177 >> AND IT IS CONSISTENT WITH 770 00:46:54,177 --> 00:46:54,778 WHAT WE'VE TRIED TO DO IN THE 771 00:46:54,778 --> 00:46:54,978 PAST. 772 00:46:54,978 --> 00:46:55,612 WE APPRECIATE THE COMMENT WE MAY 773 00:46:55,612 --> 00:46:56,146 HAVE A HOST INSTITUTION OR 774 00:46:56,146 --> 00:47:00,284 UNIVERSITY BUT THEN COMMUNICATE 775 00:47:00,284 --> 00:47:00,918 WITH THE COMMUNITY COLLEGES ARE 776 00:47:00,918 --> 00:47:01,552 OTHER INSTITUTIONS THAT ARE NOT 777 00:47:01,552 --> 00:47:03,520 TRADITIONAL RESEARCH 778 00:47:03,520 --> 00:47:04,121 INSTITUTIONS AND PEOPLE TRAVEL 779 00:47:04,121 --> 00:47:07,758 HUNDREDS OF MILES SOMETIMES TO 780 00:47:07,758 --> 00:47:12,529 THESE REGIONAL MEETINGS AND WE 781 00:47:12,529 --> 00:47:22,739 WILL CONTINUE TO DO THAT. 782 00:47:22,739 --> 00:47:26,310 >> I WAS JUST THINKING OF THE 783 00:47:26,310 --> 00:47:27,778 PRESENTATIONS. 784 00:47:27,778 --> 00:47:33,550 I WAS SMILING THE WHOLE TIME IT 785 00:47:33,550 --> 00:47:38,422 IS TRULY EXCITING MY HEART WAS 786 00:47:38,422 --> 00:47:40,591 JUMPING TALK ABOUT THE VISIT 787 00:47:40,591 --> 00:47:44,428 WITH THE CHEROKEE NATION I LOVE 788 00:47:44,428 --> 00:47:53,370 THIS KIND OF WORK. 789 00:47:53,370 --> 00:47:53,904 IT IS RIGHT THERE WITH THE 790 00:47:53,904 --> 00:47:54,137 PEOPLE. 791 00:47:54,137 --> 00:47:54,671 IT IS EXTREMELY POWERFUL. 792 00:47:54,671 --> 00:47:57,407 AND ALSO 1 SUGGESTION. 793 00:47:57,407 --> 00:48:02,746 I'M PERSONALLY LEARNING MORE OF 794 00:48:02,746 --> 00:48:11,989 US TERRITORIES. 795 00:48:11,989 --> 00:48:13,523 BUT JUST IN GENERAL AND THE 796 00:48:13,523 --> 00:48:19,096 COMMUNITIES THAT TYPICALLY THAT 797 00:48:19,096 --> 00:48:24,835 WE DON'T TALK TOO MUCH ABOUT 798 00:48:24,835 --> 00:48:28,071 THEM AND THEN TO ESTABLISH THE 799 00:48:28,071 --> 00:48:33,110 CONVERSATIONS. 800 00:48:33,110 --> 00:48:37,581 >> YES PUERTO RICO IS ALSO 1 OF 801 00:48:37,581 --> 00:48:44,421 OUR SUCCESSFUL PLACES. 802 00:48:44,421 --> 00:48:47,057 >> I WAS GOING TO ECHO THE SAME 803 00:48:47,057 --> 00:48:56,533 THING GRACIOUSLY HOSTING US IN 804 00:48:56,533 --> 00:48:57,100 2021 DOING A FABULOUS JOB TO 805 00:48:57,100 --> 00:48:57,634 SPREAD THE WORD GARNERING 806 00:48:57,634 --> 00:48:58,235 SUPPORT FROM 15 OTHER ACADEMIC 807 00:48:58,235 --> 00:48:58,769 INSTITUTIONS AND RESEARCH 808 00:48:58,769 --> 00:49:00,203 LABORATORIES ON THE ISLAND A 809 00:49:00,203 --> 00:49:02,739 WONDERFUL TURNOUT IT HAPPENED 810 00:49:02,739 --> 00:49:04,041 VIRTUALLY IT WAS THE FIRST 811 00:49:04,041 --> 00:49:06,343 OPPORTUNITY TO OFFER A HYBRID 812 00:49:06,343 --> 00:49:10,313 FORMAT BUT THE ENTHUSIASM WAS NO 813 00:49:10,313 --> 00:49:15,318 DIFFERENT BUT WE WILL CERTAINLY 814 00:49:15,318 --> 00:49:15,952 ADD THAT TO THE LIST TO EXPLORE 815 00:49:15,952 --> 00:49:26,329 OTHER US TERRITORIES. 816 00:49:31,601 --> 00:49:34,104 >> SO JUST THINKING ABOUT WHY 817 00:49:34,104 --> 00:49:39,176 THE PROGRAMS ENGAGE PRECOLLEGE 818 00:49:39,176 --> 00:49:46,016 BUT ALSO COLLEGE STUDENTS TO 819 00:49:46,016 --> 00:49:46,616 ACTIVELY PURSUE CAREERS AND I 820 00:49:46,616 --> 00:49:50,120 THINK IF WE COULD ADD AGING TO 821 00:49:50,120 --> 00:49:52,556 THE CONVERSATION IT WOULD BE SO 822 00:49:52,556 --> 00:50:01,098 HELPFUL. 823 00:50:01,098 --> 00:50:01,665 IN JUST THE LARGEST COLLEGE 824 00:50:01,665 --> 00:50:02,199 SYSTEM IN THE WORLD IS CAL 825 00:50:02,199 --> 00:50:02,399 STATE. 826 00:50:02,399 --> 00:50:11,641 MY SISTER IS A DEAN THERE. 827 00:50:11,641 --> 00:50:12,175 SHE RUNS THE STEM PROGRAM. 828 00:50:12,175 --> 00:50:12,776 IF THAT COULD BE OF INTEREST I 829 00:50:12,776 --> 00:50:13,343 WOULD BE HAPPY TO HELP MAKE 830 00:50:13,343 --> 00:50:13,944 CONNECTIONS THEY ARE JUST AS A 831 00:50:13,944 --> 00:50:16,680 CONSIDERATION WITH UNTAPPED 832 00:50:16,680 --> 00:50:19,549 TERRITORY FOR NIH AND ALL OF THE 833 00:50:19,549 --> 00:50:29,726 POTENTIAL. 834 00:50:30,393 --> 00:50:37,601 >> COMMENTS OR QUESTIONS? 835 00:50:37,601 --> 00:50:39,503 >> THANK YOU ALL FOR BRINGING 836 00:50:39,503 --> 00:50:42,105 ENGAGED DISCUSSION. 837 00:50:42,105 --> 00:50:48,011 >> THANK YOU. 838 00:50:48,011 --> 00:50:54,851 NEXT TO GIVE YOU AN UPDATE ON 839 00:50:54,851 --> 00:50:58,255 FUTURE MEETINGS 2024 AND 2025. 840 00:50:58,255 --> 00:51:04,795 THE NEXT 2 IN PERSON MEETINGS 841 00:51:04,795 --> 00:51:11,968 MAY 21 AND 22 AND SEPTEMBER 18 842 00:51:11,968 --> 00:51:12,202 AND 19. 843 00:51:12,202 --> 00:51:17,207 AND IN 2025 MAY 13 AND 14 AND 844 00:51:17,207 --> 00:51:19,509 SEPTEMBER 17 AND 18. 845 00:51:19,509 --> 00:51:27,083 STAY TUNED FOR THOSE AND WE WILL 846 00:51:27,083 --> 00:51:28,385 BE SENDING OUT MORE INFORMATION 847 00:51:28,385 --> 00:51:34,891 IN THE FUTURE. 848 00:51:34,891 --> 00:51:35,492 SOMETHING ON THE AGENDA IS THE 849 00:51:35,492 --> 00:51:36,126 CONSIDERATION OF NATIONAL 850 00:51:36,126 --> 00:51:41,064 ADVISORY COUNCIL ON AGING THE 851 00:51:41,064 --> 00:51:42,566 MEETINGS ON THE LAST COUNSEL WAS 852 00:51:42,566 --> 00:51:46,036 SEPTEMBER 2023 AND THEN PROVIDED 853 00:51:46,036 --> 00:51:54,244 WITH A COPY OF THOSE MINUTES ARE 854 00:51:54,244 --> 00:51:57,447 THERE ANY QUESTIONS OR ADDITIONS 855 00:51:57,447 --> 00:52:03,820 TO THE MINUTES? 856 00:52:03,820 --> 00:52:06,256 NOT HEARING ANY TO GET A MOTION 857 00:52:06,256 --> 00:52:09,159 TO APPROVE THE MINUTES? 858 00:52:09,159 --> 00:52:16,132 ALL THOSE IN FAVOR? 859 00:52:16,132 --> 00:52:16,433 ANY OPPOSED? 860 00:52:16,433 --> 00:52:17,000 THANK YOU VERY MUCH WE HAVE 861 00:52:17,000 --> 00:52:20,737 APPROVAL OF THE MINUTES FROM 862 00:52:20,737 --> 00:52:27,911 SEPTEMBER 2023. 863 00:52:27,911 --> 00:52:37,020 >> JUST TO REMIND EVERYBODY IF 864 00:52:37,020 --> 00:52:37,654 YOU ARE NOT SPEAKING PLEASE MUTE 865 00:52:37,654 --> 00:52:44,160 YOUR MICROPHONE. 866 00:52:44,160 --> 00:52:46,663 'S NOW I WILL TURN THIS OVER TO 867 00:52:46,663 --> 00:52:50,901 REPORT ON THE TASK FORCE. 868 00:52:50,901 --> 00:52:57,908 >> THANK YOU SO MUCH. 869 00:52:57,908 --> 00:53:01,745 WE HAD THE TASK FORCE MINORITY 870 00:53:01,745 --> 00:53:03,813 HEALTH DISPARITIES RESEARCH HAS 871 00:53:03,813 --> 00:53:06,249 THE PLEASURE OF PHENOMENAL 872 00:53:06,249 --> 00:53:10,120 PRESENTATIONS YESTERDAY MORNING 873 00:53:10,120 --> 00:53:11,187 GOING TO THE WORKFORCE 874 00:53:11,187 --> 00:53:13,890 PIPELINE. 875 00:53:13,890 --> 00:53:18,028 SO IN THAT SPIRIT WE HAVE DOCTOR 876 00:53:18,028 --> 00:53:20,230 EVANS FROM THE NATIONAL 877 00:53:20,230 --> 00:53:23,967 INSTITUTE OF AGING. 878 00:53:23,967 --> 00:53:32,208 AND SHE TALKED ABOUT THE 879 00:53:32,208 --> 00:53:32,742 RESEARCH PROGRAMS AND THE 880 00:53:32,742 --> 00:53:33,376 EFFORTS UNDERTAKING TO DIVERSIFY 881 00:53:33,376 --> 00:53:33,910 THE TRAINING FOR THE NEXT 882 00:53:33,910 --> 00:53:35,946 GENERATION. 883 00:53:35,946 --> 00:53:41,084 SHE HIGHLIGHTED NIH PROGRAMS 884 00:53:41,084 --> 00:53:44,154 SPECIFICALLY AT NIH WITH THE 885 00:53:44,154 --> 00:53:47,324 NEXT GENERATION OF RESEARCHERS 886 00:53:47,324 --> 00:53:50,060 SHE REMINDED US THAT THE 887 00:53:50,060 --> 00:53:56,032 TRAINING POPULATION AS OF 888 00:53:56,032 --> 00:53:58,868 NOW, JANUARY 2024 IS 197 WHICH I 889 00:53:58,868 --> 00:54:03,673 THINK IS A PHENOMENAL NUMBER. 890 00:54:03,673 --> 00:54:06,109 AND SHE ALSO REMINDED US TO MEET 891 00:54:06,109 --> 00:54:10,680 THE GOALS USING THE STRATEGIES 892 00:54:10,680 --> 00:54:15,685 TO PROMOTE PARTICIPATION IN ALL 893 00:54:15,685 --> 00:54:16,319 NIH SPONSORED TRAINING PROGRAMS 894 00:54:16,319 --> 00:54:22,726 AND THEN TO DEVELOP SPECIFIC 895 00:54:22,726 --> 00:54:23,059 SPECIFICALLY. 896 00:54:23,059 --> 00:54:25,962 SHE HIGHLIGHTED THE SUMMER 897 00:54:25,962 --> 00:54:28,932 PROGRAMS WHICH IS FOR HIGH 898 00:54:28,932 --> 00:54:38,141 SCHOOL STUDENTS AND ALSO 899 00:54:38,141 --> 00:54:38,675 HIGHLIGHTED FOR COMMUNITY 900 00:54:38,675 --> 00:54:42,345 COLLEGES AND WORK FORCE 901 00:54:42,345 --> 00:54:42,912 RECRUITMENT THAT CONNECTING 902 00:54:42,912 --> 00:54:49,986 FEDERAL AND PRIVATE SECTOR 903 00:54:49,986 --> 00:54:50,620 NATIONWIDE WITH HIGHLY MOTIVATED 904 00:54:50,620 --> 00:54:51,221 STUDENTS AND RECENT GRADUATES 905 00:54:51,221 --> 00:54:53,690 WITH DISABILITIES. 906 00:54:53,690 --> 00:54:58,495 ALSO TALKING ABOUT DIVERSITY 907 00:54:58,495 --> 00:55:06,369 AGING RESEARCH AND THEN FOR 908 00:55:06,369 --> 00:55:08,705 INTRODUCTION FOR LABORATORY 909 00:55:08,705 --> 00:55:12,008 SKILLS AND FOR THE BALL TO ROLL 910 00:55:12,008 --> 00:55:15,078 HER HIGH SCHOOL PROGRAM FOR KIDS 911 00:55:15,078 --> 00:55:19,749 YOUNGER THAN 17 YEARS OLD. 912 00:55:19,749 --> 00:55:23,119 WITH THE BIOMEDICAL FOR AGING 913 00:55:23,119 --> 00:55:26,823 SCIENCE. 914 00:55:26,823 --> 00:55:31,227 AND A WORD IS TOUCHED BY THE 915 00:55:31,227 --> 00:55:34,764 RICH CONVERSATION AMONG THE 916 00:55:34,764 --> 00:55:38,535 PANEL MEMBERS AND SOME OF THOSE 917 00:55:38,535 --> 00:55:44,007 THAT I TOOK AWAY WAS EXPLORING 918 00:55:44,007 --> 00:55:45,775 WAYS TO INCLUDE MORE AMERICANS 919 00:55:45,775 --> 00:55:51,848 IN THESE PROGRAMS AND TO LOOK 920 00:55:51,848 --> 00:55:58,621 FOR WAYS FOR THIS NATIONWIDE AND 921 00:55:58,621 --> 00:55:59,389 ARE IMPORTANT FOR THESE TOPICS 922 00:55:59,389 --> 00:56:09,899 TO CONTINUE AND THEN THE PANEL 923 00:56:11,701 --> 00:56:20,443 MEMBERS AND THEN TO IN FACT 924 00:56:20,443 --> 00:56:23,513 IMPACT THE WORKFORCE PIPELINE. 925 00:56:23,513 --> 00:56:30,787 AND THEN WE HEARD FROM DOCTOR 926 00:56:30,787 --> 00:56:39,729 CAMPBELL AND THEN TO MINOR TIES 927 00:56:39,729 --> 00:56:40,363 WOMEN AND DIVERSE UNDERGRADUATES 928 00:56:40,363 --> 00:56:48,538 TO BE LEADERS. 929 00:56:48,538 --> 00:56:49,105 AND THEN WITH THAT MINORITY 930 00:56:49,105 --> 00:56:54,010 SERVING INSTITUTION TO EDUCATE 931 00:56:54,010 --> 00:56:56,212 WOMEN. 932 00:56:56,212 --> 00:56:58,748 OF COURSE THAT WAS MUSIC TO MY 933 00:56:58,748 --> 00:57:03,186 EARS AND THEN TO UNDERSTAND THE 934 00:57:03,186 --> 00:57:05,889 VALUE OF THAT. 935 00:57:05,889 --> 00:57:10,326 HIGHLIGHTING THE CARE PROGRAM 936 00:57:10,326 --> 00:57:11,361 ADVANCING DIVERSITY WITH AGING 937 00:57:11,361 --> 00:57:17,267 RESEARCH PROGRAM AND SHE 938 00:57:17,267 --> 00:57:17,901 HIGHLIGHTED SOME OF THE FEATURES 939 00:57:17,901 --> 00:57:23,106 OF THE CARE PROGRAM IT IS A 940 00:57:23,106 --> 00:57:23,673 MULTI- CARE RESEARCH PROGRAM 941 00:57:23,673 --> 00:57:30,647 FOCUS ON GENERAL SCIENCE AND THE 942 00:57:30,647 --> 00:57:33,116 ONLY PROGRAM IN THE UPPER 943 00:57:33,116 --> 00:57:39,622 MIDWEST AND 100 PERCENT OF THE 944 00:57:39,622 --> 00:57:43,493 STUDENTS A COMPLETE THE PROGRAM 945 00:57:43,493 --> 00:57:50,166 WITH A CAREER IN RESEARCH. 946 00:57:50,166 --> 00:58:00,677 SHE TALKED TO US TALKING ABOUT 947 00:58:05,648 --> 00:58:06,149 THE INJUSTICE THAT WE SEE IN 948 00:58:06,149 --> 00:58:06,649 HEALTH DISPARITIES THAT 949 00:58:06,649 --> 00:58:07,283 ACCUMULATE OVER THE LIFE SPY -- 950 00:58:07,283 --> 00:58:07,850 -- LIFESPAN OF A MINOR TIES 951 00:58:07,850 --> 00:58:08,685 POPULATION. 952 00:58:08,685 --> 00:58:11,120 AND FOR ME SOME OF THE KEY 953 00:58:11,120 --> 00:58:13,890 POINTS THAT WE TAKE AWAY FROM 954 00:58:13,890 --> 00:58:21,164 THIS TO HIGHLIGHT HIS TRAINING 955 00:58:21,164 --> 00:58:21,764 THAT NEXT GENERATION OF AGING 956 00:58:21,764 --> 00:58:24,767 RESEARCHERS IS FUNDAMENTAL TO 957 00:58:24,767 --> 00:58:25,401 ADDRESS THE HEALTH OF THE NATION 958 00:58:25,401 --> 00:58:25,902 AND TO DEAL WITH HEALTH 959 00:58:25,902 --> 00:58:30,506 INEQUITIES. 960 00:58:30,506 --> 00:58:36,112 AND ALSO THOSE PERSPECTIVES ARE 961 00:58:36,112 --> 00:58:41,684 ALSO INVALUABLE. 962 00:58:41,684 --> 00:58:45,355 THE IDEA AS A WAY TO SUMMARIZE 963 00:58:45,355 --> 00:58:47,790 SOCIAL JUSTICE WITH AN AGING 964 00:58:47,790 --> 00:58:52,862 POPULATION SO THAT IN TERMS OF 965 00:58:52,862 --> 00:58:56,899 OPPORTUNITIES AGAINST ALL 966 00:58:56,899 --> 00:58:57,767 DEMOGRAPHIC GROUPS IS 967 00:58:57,767 --> 00:59:02,138 FUNDAMENTAL. 968 00:59:02,138 --> 00:59:08,678 AND BEFORE I TURN IT OVER TO 969 00:59:08,678 --> 00:59:09,312 DOCTOR SNYDER FOR HER COMMENTS I 970 00:59:09,312 --> 00:59:11,281 BRIEFLY WANT TO RECOGNIZE DOCTOR 971 00:59:11,281 --> 00:59:16,119 JONES FOR ORGANIZING AND LEADING 972 00:59:16,119 --> 00:59:20,189 US TO THIS POINT. 973 00:59:20,189 --> 00:59:27,930 >> THANK YOU SO MUCH I 974 00:59:27,930 --> 00:59:28,865 APPRECIATE THAT ALSO EXTENDING 975 00:59:28,865 --> 00:59:31,768 MY THINKS BOTH TO YOU AND DOCTOR 976 00:59:31,768 --> 00:59:38,975 JONES FOR INVITING ME. 977 00:59:38,975 --> 00:59:41,010 IT HAS BEEN VERY EXCITING AND 978 00:59:41,010 --> 00:59:43,680 FULFILLING. 979 00:59:43,680 --> 00:59:46,416 THE 2 SPEAKERS. 980 00:59:46,416 --> 00:59:48,951 I WILL GIVE YOU A BRIEF HISTORY 981 00:59:48,951 --> 00:59:59,462 BUT THE 2 SPEAKERS THAT SPOKE. 982 01:00:03,700 --> 01:00:10,139 [INAUDIBLE] 983 01:00:10,139 --> 01:00:12,675 I THOUGHT I WOULD JUST TELL 984 01:00:12,675 --> 01:00:16,379 EVERYBODY AND I LOOKED THIS UP 985 01:00:16,379 --> 01:00:22,018 SO IT WAS FASCINATING FOR ME 986 01:00:22,018 --> 01:00:22,652 ACTUALLY AS AN AMERICAN SURGEON 987 01:00:22,652 --> 01:00:23,653 AND MEDICAL RESEARCHER BORN 19 988 01:00:23,653 --> 01:00:29,392 OH 4 AND HAD AN UNTIMELY DEATH 989 01:00:29,392 --> 01:00:30,226 IN 1950 RESEARCHING BLOOD 990 01:00:30,226 --> 01:00:34,964 TRANSFUSIONS AND WITH APPROVED 991 01:00:34,964 --> 01:00:35,998 TECHNIQUES TO DISTORT - - TO 992 01:00:35,998 --> 01:00:42,972 STORE BLOOD. 993 01:00:42,972 --> 01:00:43,539 AND THIS SAVED THOUSANDS OF 994 01:00:43,539 --> 01:00:45,007 ALLIED FORCES LIVES DURING THE 995 01:00:45,007 --> 01:00:47,744 WAR. 996 01:00:47,744 --> 01:00:48,211 WAS THE MOST PROMINENT 997 01:00:48,211 --> 01:00:53,416 AFRICAN-AMERICAN IN THE FIELD. 998 01:00:53,416 --> 01:00:54,884 BUT HE PROTESTED RACIAL 999 01:00:54,884 --> 01:00:59,288 SEGREGATION AND DONATION OF 1000 01:00:59,288 --> 01:01:02,024 BLOOD AND HE RESIGNED HIS 1001 01:01:02,024 --> 01:01:05,294 POSITION TO THE AMERICAN RED 1002 01:01:05,294 --> 01:01:13,202 CROSS THROUGH 1950. 1003 01:01:13,202 --> 01:01:13,603 A REMARKABLE MAN. 1004 01:01:13,603 --> 01:01:14,103 L WHOLE WIKIPEDIA PAGE. 1005 01:01:14,103 --> 01:01:14,670 I ENCOURAGE YOU TO LOOK AT 1006 01:01:14,670 --> 01:01:23,045 THIS. 1007 01:01:23,045 --> 01:01:23,546 SO I WILL MOVE ON TO THE 1008 01:01:23,546 --> 01:01:24,414 PRESENTATION SO NOW THE FOUNDING 1009 01:01:24,414 --> 01:01:31,087 OF THE PROGRAM FROM THE 1010 01:01:31,087 --> 01:01:31,654 UNIVERSITY MEDICAID IS -- -- 1011 01:01:31,654 --> 01:01:37,293 MEDICINE AND SCIENCE IN L.A. IT 1012 01:01:37,293 --> 01:01:37,927 IS ONLY THE FOURTH HBCU PROGRAM 1013 01:01:37,927 --> 01:01:40,163 OF UNDERREPRESENTED IT COMMUNITY 1014 01:01:40,163 --> 01:01:43,666 SCHOOLS FOR TO OBTAIN THE MD. 1015 01:01:43,666 --> 01:01:48,971 PARTNERSHIP WITH UCLA THAT SHE 1016 01:01:48,971 --> 01:01:49,572 TOLD US ABOUT AND THE HISTORY 1017 01:01:49,572 --> 01:01:52,809 AND RESEARCH AND SERVICE. 1018 01:01:52,809 --> 01:01:53,810 SHE TOLD US ABOUT THE SOCIAL 1019 01:01:53,810 --> 01:02:04,287 ECONOMIC STATUS AND THE PELL 1020 01:02:06,722 --> 01:02:07,190 GRANT RECIPIENTS THE FIRST 1021 01:02:07,190 --> 01:02:07,824 COHORT WILL GRADUATE 2027 SO SHE 1022 01:02:07,824 --> 01:02:08,291 DOESN'T HAVE A LOT OF 1023 01:02:08,291 --> 01:02:08,858 INFORMATION YET BUT THEY ARE 1024 01:02:08,858 --> 01:02:09,459 VERY EXCITED ABOUT THE PROGRAM 1025 01:02:09,459 --> 01:02:14,597 WITH A LONG-STANDING GOAL TO 1026 01:02:14,597 --> 01:02:17,099 TRAIN THE NEXT GENERATION OF 1027 01:02:17,099 --> 01:02:20,269 DOCTORS. 1028 01:02:20,269 --> 01:02:21,204 BUT IN ADDITION TO STRESS THE 1029 01:02:21,204 --> 01:02:28,344 UNDERLYING GOALS NOT ONLY WAS 1030 01:02:28,344 --> 01:02:33,683 TRAINED DOCTORS AND COMMUNITY 1031 01:02:33,683 --> 01:02:41,591 EDUCATION AND OUR SECOND SPEAKER 1032 01:02:41,591 --> 01:02:42,225 IS ENGAGING STUDENTS FROM LOCAL 1033 01:02:42,225 --> 01:02:44,160 COMMUNITY COLLEGES OF AGING 1034 01:02:44,160 --> 01:02:46,529 RESEARCH AND IS THE DIRECTOR OF 1035 01:02:46,529 --> 01:02:52,535 THE PIPELINE PROGRAM AT CHARLES 1036 01:02:52,535 --> 01:02:59,275 DREW SHE TOLD US MOSTLY HOW MANY 1037 01:02:59,275 --> 01:03:01,377 PEOPLE START IN COMMUNITY 1038 01:03:01,377 --> 01:03:03,346 COLLEGES AND THEIR GOAL IS TO 1039 01:03:03,346 --> 01:03:07,783 PRESENT RESEARCH SO THEY CAN 1040 01:03:07,783 --> 01:03:09,151 MOVE ON AND DO RESEARCH AT 1041 01:03:09,151 --> 01:03:16,859 UNIVERSITIES THOSE WHO DO END UP 1042 01:03:16,859 --> 01:03:19,095 MATRICULATING COME UP FROM A 1043 01:03:19,095 --> 01:03:21,130 COMMUNITY COLLEGE STANDPOINT AND 1044 01:03:21,130 --> 01:03:22,899 IT'S VERY COMMON FOR PEOPLE TO 1045 01:03:22,899 --> 01:03:28,938 START THEIR. 1046 01:03:28,938 --> 01:03:30,006 SO TRYING TO BUILD A PIPELINE OF 1047 01:03:30,006 --> 01:03:36,779 AGING RESEARCH THROUGH THE 1048 01:03:36,779 --> 01:03:37,046 STUDENTS. 1049 01:03:37,046 --> 01:03:37,713 THIS IS THE BEGINNING THE GOAL 1050 01:03:37,713 --> 01:03:43,519 IS TO HAVE RACIAL ETHNIC DIVERSE 1051 01:03:43,519 --> 01:03:51,360 WORKFORCE. 1052 01:03:51,360 --> 01:03:52,862 AND THEN WITH AN EXCITING 1053 01:03:52,862 --> 01:03:55,865 PRESENTATION ABOUT WHAT THEY ARE 1054 01:03:55,865 --> 01:04:01,003 DOING IT IS A GREAT OPPORTUNITY 1055 01:04:01,003 --> 01:04:03,806 TO BUILD PIPELINES AND SO THERE 1056 01:04:03,806 --> 01:04:09,712 IS A LOT OF DISCUSSION AND THEY 1057 01:04:09,712 --> 01:04:10,212 WERE EXCITED TO HEAR OUR 1058 01:04:10,212 --> 01:04:16,852 EXCITEMENT ABOUT THE PROGRAMS. 1059 01:04:16,852 --> 01:04:17,486 ANOTHER THING THAT WAS DISCUSSED 1060 01:04:17,486 --> 01:04:18,054 AS THE DIVERSITY SUPPLEMENTS 1061 01:04:18,054 --> 01:04:19,422 THERE'S A REALLY GOOD AVENUE FOR 1062 01:04:19,422 --> 01:04:23,125 TRAINING. 1063 01:04:23,125 --> 01:04:23,726 AND WE MOVED INTO A DISCUSSION 1064 01:04:23,726 --> 01:04:25,127 ABOUT HOW DO WE ENCOURAGE 1065 01:04:25,127 --> 01:04:27,964 INSTITUTIONS TO ACTUALLY HAVE 1066 01:04:27,964 --> 01:04:36,405 THE INCENTIVE? 1067 01:04:36,405 --> 01:04:37,006 AND IT'S ALWAYS HARD TO PEOPLE 1068 01:04:37,006 --> 01:04:37,607 TO COME IN A MENTOR THERE'S A 1069 01:04:37,607 --> 01:04:42,178 LOT OF DISCUSSION ABOUT THAT. 1070 01:04:42,178 --> 01:04:42,812 INTERESTING COMMENTS OF ALL THE 1071 01:04:42,812 --> 01:04:45,648 THINGS AVAILABLE AT AN IA TO 1072 01:04:45,648 --> 01:04:48,818 LOOK AT. 1073 01:04:48,818 --> 01:04:53,723 ALSO MENTIONING THE PROGRAM 1074 01:04:53,723 --> 01:04:56,959 WHICH IS A PRE- K PROGRAM SO 1075 01:04:56,959 --> 01:05:07,503 OVERALL I THOUGHT IT WAS A GOOD 1076 01:05:09,205 --> 01:05:09,739 GROUP OF PEOPLE DISCUSSING HOW 1077 01:05:09,739 --> 01:05:10,306 IMPORTANT THE PIPELINE IS TO 1078 01:05:10,306 --> 01:05:10,906 CREATE A WORKFORCE OF PEACE IN 1079 01:05:10,906 --> 01:05:13,943 THE CAN SEE. 1080 01:05:13,943 --> 01:05:18,214 IT WAS A PLEASURE TO DO THIS. 1081 01:05:18,214 --> 01:05:25,521 THANK YOU FOR INVITING ME. 1082 01:05:25,521 --> 01:05:29,825 >> THANK YOU FOR YOUR SUMMARY. 1083 01:05:29,825 --> 01:05:40,269 ANY QUESTIONS OR COMMENTS? 1084 01:05:54,483 --> 01:05:55,051 >> I ECHO THE COMMENTS WITH THE 1085 01:05:55,051 --> 01:06:00,523 WARM WELCOME BOTH YOU HAVE BEEN 1086 01:06:00,523 --> 01:06:01,057 WONDERFUL ADDITIONS TO THE 1087 01:06:01,057 --> 01:06:01,657 PROCESS AND WE LOOK FORWARD TO 1088 01:06:01,657 --> 01:06:03,559 HEARING WHAT ADDITIONAL IDEAS 1089 01:06:03,559 --> 01:06:04,593 THE COUNCIL WISHES US TO PURSUE 1090 01:06:04,593 --> 01:06:14,870 AS A TASK FORCE. 1091 01:06:15,705 --> 01:06:16,672 STATES THAT WE LOOK FORWARD TO 1092 01:06:16,672 --> 01:06:20,643 BEING COCHAIR OF THIS TASK FORCE 1093 01:06:20,643 --> 01:06:24,980 AND THE RECOMMENDATIONS IN 1094 01:06:24,980 --> 01:06:33,055 FUTURE MEETINGS. 1095 01:06:33,055 --> 01:06:33,689 >> I JUST WANT TO SAY I THOUGHT 1096 01:06:33,689 --> 01:06:34,623 THIS WAS AND INSPIRING 1097 01:06:34,623 --> 01:06:39,361 PRESENTATION FOR WHAT PEOPLE 1098 01:06:39,361 --> 01:06:49,038 WERE DOING ON THE GROUND WITH 1099 01:06:49,038 --> 01:06:51,941 THE ATTENTION THAT DOCTOR JONES 1100 01:06:51,941 --> 01:06:55,511 BRINGS TO THE TASK FORCE CHAIRS 1101 01:06:55,511 --> 01:06:56,545 WITH THAT SORT THE 1102 01:06:56,545 --> 01:07:03,719 PRESENTATIONS. 1103 01:07:03,719 --> 01:07:14,163 AND REALLY TO BE INSPIRED. 1104 01:07:17,266 --> 01:07:18,734 >> ANY OTHER QUESTIONS OR 1105 01:07:18,734 --> 01:07:23,339 COMMENTS? 1106 01:07:23,339 --> 01:07:33,682 THANK YOU VERY MUCH. 1107 01:07:36,085 --> 01:07:36,652 SO NOW WE WILL TURN THE SECTION 1108 01:07:36,652 --> 01:07:39,155 OVER TO OUR CHAIR. 1109 01:07:39,155 --> 01:07:45,795 >> THANK YOU TO ALL 1110 01:07:45,795 --> 01:07:46,395 COUNCILMEMBERS FOR THEIR VERY 1111 01:07:46,395 --> 01:07:47,096 THOROUGH REVIEW AND HELPFUL 1112 01:07:47,096 --> 01:07:53,636 DISCUSSION. 1113 01:07:53,636 --> 01:07:54,136 WE HAD 14 CONCEPTS TO GO 1114 01:07:54,136 --> 01:07:55,004 THROUGH'S WE HAVE THE PRIMARY 1115 01:07:55,004 --> 01:07:57,173 REVIEW. 1116 01:07:57,173 --> 01:08:01,177 WITH A SUMMARY OF THE CONCEPT IN 1117 01:08:01,177 --> 01:08:01,544 THE DISCUSSION. 1118 01:08:01,544 --> 01:08:08,317 SO THE FIRST CONCEPT WAS AN IA 1119 01:08:08,317 --> 01:08:10,186 AGING SAILOR REPOSITORY WITH 1120 01:08:10,186 --> 01:08:18,260 CONTRACT RENEWAL WITH DOCTOR 1121 01:08:18,260 --> 01:08:18,794 PETERSON AND DOCTOR BAKER. 1122 01:08:18,794 --> 01:08:22,231 >> I'M HAPPY TO GIVE A SUMMARY. 1123 01:08:22,231 --> 01:08:23,232 A REQUEST FROM THE DIVISION OF 1124 01:08:23,232 --> 01:08:28,337 AGING BIOLOGY FROM MEDICAL 1125 01:08:28,337 --> 01:08:33,409 RESEARCH WHICH HELPS TO MAINTAIN 1126 01:08:33,409 --> 01:08:43,385 THE NIA AGING REPOSITORY. 1127 01:08:43,385 --> 01:08:43,986 AND THEN WITH THAT AGING CELL 1128 01:08:43,986 --> 01:08:46,722 REPOSITORY WAS STARTED IN 1974. 1129 01:08:46,722 --> 01:08:49,258 THIS WAS A LONG-TERM INITIATIVE 1130 01:08:49,258 --> 01:08:59,802 AND HAS A NUMBER OF RENEWALS AND 1131 01:09:00,135 --> 01:09:00,669 THAT THE SCOPE WE STARTED THE 1132 01:09:00,669 --> 01:09:01,303 REPOSITORY IN THE PURPOSE IS TO 1133 01:09:01,303 --> 01:09:01,871 PRODUCE AND CHARACTERIZE AND 1134 01:09:01,871 --> 01:09:06,675 DISTRIBUTE HUMAN AND ANIMAL CELL 1135 01:09:06,675 --> 01:09:07,176 LINES TO THE COMMUNITY. 1136 01:09:07,176 --> 01:09:09,178 CELLS ON THE REPOSITORY 1137 01:09:09,178 --> 01:09:13,148 ORIGINATE FROM 42 ANIMAL SPEC 1138 01:09:13,148 --> 01:09:20,623 SPECIES, 27 NONHUMAN PRIMATES 1139 01:09:20,623 --> 01:09:24,426 THE REPOSITORY HAS OVER 3000 1140 01:09:24,426 --> 01:09:26,328 LINES IN THE MAJORITY ARE OF 1141 01:09:26,328 --> 01:09:35,604 HUMAN ORIGINS. 1142 01:09:35,604 --> 01:09:36,238 AND THOSE WITH HEALTHY HUMANS OF 1143 01:09:36,238 --> 01:09:38,908 DIFFERENT AGES AND ABOUT 1144 01:09:38,908 --> 01:09:46,548 50 PERCENT OF THE PEOPLE AND ARE 1145 01:09:46,548 --> 01:09:51,754 ALSO DIVERSE IN 20 PERCENT ARE 1146 01:09:51,754 --> 01:09:52,755 NONWHITE AND EQUALLY 1147 01:09:52,755 --> 01:09:56,292 DISTRIBUTED. 1148 01:09:56,292 --> 01:10:02,898 SO THE USE OF THE REPOSITORY 1149 01:10:02,898 --> 01:10:03,399 WITH AN AVERAGE OF 12000 1150 01:10:03,399 --> 01:10:04,066 CELLULAR LINES ARE SENT OUT 1151 01:10:04,066 --> 01:10:06,669 EVERY YEAR. 1152 01:10:06,669 --> 01:10:09,838 BUT ALSO INTERNATIONALLY MOST 1153 01:10:09,838 --> 01:10:15,544 ARE REQUESTED FROM HUMANS AND 1154 01:10:15,544 --> 01:10:16,145 THEN TO DISCUSS THE FACT THERE 1155 01:10:16,145 --> 01:10:19,949 HAS BEEN AN INCREASE WAS 1156 01:10:19,949 --> 01:10:20,549 RESPONSE SO THE REPOSITORY HAS 1157 01:10:20,549 --> 01:10:25,020 EXPANDED THE EFFORT IN THE LAST 1158 01:10:25,020 --> 01:10:35,531 YEAR TO COLLECT MORE FROM THE 1159 01:10:41,904 --> 01:10:42,471 NONHUMAN PRIMATES THERE IS MUCH 1160 01:10:42,471 --> 01:10:43,072 LESS INTERESTED IN ANIMAL CELL 1161 01:10:43,072 --> 01:10:43,672 LINES TO CONTINUE TO MAINTAIN 1162 01:10:43,672 --> 01:10:44,306 THE LINES THAT THEY HAVE BUT NO 1163 01:10:44,306 --> 01:10:44,873 PLANS TO EXPAND GREATLY THE 1164 01:10:44,873 --> 01:10:45,341 DOMESTIC ANIMAL LINES. 1165 01:10:45,341 --> 01:10:48,477 THE PUBLICATIONS FROM THE 1166 01:10:48,477 --> 01:10:53,415 RESOURCE HAS BEEN TREMENDOUS BUT 1167 01:10:53,415 --> 01:10:58,787 JUST IN THE PAST 3 YEARS 150 1168 01:10:58,787 --> 01:11:05,728 PUBLICATIONS BUT THIS REPOSITORY 1169 01:11:05,728 --> 01:11:14,303 REALLY ADDRESSES 2 MAJOR GOALS 1170 01:11:14,303 --> 01:11:14,803 OF THE AN IA TO PROVIDE 1171 01:11:14,803 --> 01:11:15,337 RESOURCES TO THE RESEARCH 1172 01:11:15,337 --> 01:11:15,971 COMMUNITY TO ENABLE RESEARCH AND 1173 01:11:15,971 --> 01:11:18,340 ALSO INDIRECTLY TO LEAD TO A 1174 01:11:18,340 --> 01:11:23,946 BETTER UNDERSTANDING AND TO USE 1175 01:11:23,946 --> 01:11:29,585 THESE TO HAVE NEW STRATEGIES TO 1176 01:11:29,585 --> 01:11:30,185 PREVENT DISEASE THAT DECLINES 1177 01:11:30,185 --> 01:11:34,923 WITH AGE. 1178 01:11:34,923 --> 01:11:35,557 THERE WAS GREAT ENTHUSIASM AMONG 1179 01:11:35,557 --> 01:11:40,095 THE COUNCIL TO SUPPORT THE 1180 01:11:40,095 --> 01:11:40,729 RENEWAL A VALUABLE RESOURCE VERY 1181 01:11:40,729 --> 01:11:44,767 WELL MANAGED AND UTILIZED IN 1182 01:11:44,767 --> 01:11:45,234 RESEARCH COMMUNITIES. 1183 01:11:45,234 --> 01:11:50,906 WE WERE STRONGLY IN FAVOR. 1184 01:11:50,906 --> 01:11:51,507 >> WE WILL HAVE A VOTE AT THE 1185 01:11:51,507 --> 01:11:52,107 VERY END OF ALL OF THEM SO NOW 1186 01:11:52,107 --> 01:11:54,009 WE WILL MOVE TO THE SECOND. 1187 01:11:54,009 --> 01:12:03,619 THE VOLUNTEER MONITORING THIS IS 1188 01:12:03,619 --> 01:12:04,219 ALSO THE CONTRACT RENEWAL AND 1189 01:12:04,219 --> 01:12:06,088 DOCTOR BAKER PLEASE DESCRIBE THE 1190 01:12:06,088 --> 01:12:08,257 CONCEPT AND THE DISCUSSION. 1191 01:12:08,257 --> 01:12:08,957 >> IT'S INTERESTING IT'S VERY 1192 01:12:08,957 --> 01:12:13,695 MUCH RELATED TO WHAT WAS JUST 1193 01:12:13,695 --> 01:12:14,730 INTRODUCED ABOUT CELLS BUT NOW 1194 01:12:14,730 --> 01:12:18,801 IT IS AGING VERTEX THAT IS 1195 01:12:18,801 --> 01:12:21,603 DISTRIBUTED THROUGH NIA OVER TO 1196 01:12:21,603 --> 01:12:25,741 VARIOUS INSTITUTIONS THIS MEANS 1197 01:12:25,741 --> 01:12:30,813 WE KNOW WHAT IS GOING ON AND 1198 01:12:30,813 --> 01:12:31,447 THAT WE CAN BRING THEM INTO THE 1199 01:12:31,447 --> 01:12:32,347 FACILITIES AND ALL OF THOSE 1200 01:12:32,347 --> 01:12:32,714 TYPES OF ISSUES. 1201 01:12:32,714 --> 01:12:40,155 SO THIS IS THAT IT IS OUTSOURCED 1202 01:12:40,155 --> 01:12:42,658 IN TERMS OF MONITORING THE 1203 01:12:42,658 --> 01:12:46,628 PATHOLOGY THOSE THAT ARE 1204 01:12:46,628 --> 01:12:47,463 ACQUIRED AND WITH THE OWN 1205 01:12:47,463 --> 01:12:50,232 RESEARCH PROGRAMS THE ALL MIDDLE 1206 01:12:50,232 --> 01:12:54,369 SENTINEL PROGRAM AND THEN THIS 1207 01:12:54,369 --> 01:13:01,410 CONTRACT IT IS USEFUL AND THEN 1208 01:13:01,410 --> 01:13:02,044 DOING A COMPLETE EXAMINATION OF 1209 01:13:02,044 --> 01:13:07,015 A HANDFUL OF ANIMALS WITH THE 1210 01:13:07,015 --> 01:13:11,553 CHANGE PATHOLOGY COLLECTING 1211 01:13:11,553 --> 01:13:12,020 BLOOD AND NECROPSY AND 1212 01:13:12,020 --> 01:13:13,722 QUESTIONABLE TISSUES. 1213 01:13:13,722 --> 01:13:18,193 AND THEN TO BE ISOLATED AND 1214 01:13:18,193 --> 01:13:19,328 LOOKING IF THERE ARE PROTO- 1215 01:13:19,328 --> 01:13:25,434 SITES IN THE ANIMALS. 1216 01:13:25,434 --> 01:13:26,068 AND NOW A RESOURCE TO UNDERSTAND 1217 01:13:26,068 --> 01:13:36,578 WHAT IS GOING ON WITH THE MICE 1218 01:13:39,448 --> 01:13:39,848 AND RATS IS A START TO 1219 01:13:39,848 --> 01:13:40,449 DISTRIBUTE TO OTHERS TO IMPORT 1220 01:13:40,449 --> 01:13:40,816 INTO FACILITIES. 1221 01:13:40,816 --> 01:13:41,416 THIS IS AN EXTREMELY IMPORTANT 1222 01:13:41,416 --> 01:13:42,017 RESOURCE AND IT MAKES SENSE TO 1223 01:13:42,017 --> 01:13:42,518 RENEW THE CONTRACT WITH 1224 01:13:42,518 --> 01:13:45,087 OVERWHELMING SUPPORT WITH THE 1225 01:13:45,087 --> 01:13:52,427 COMMITTEE YESTERDAY. 1226 01:13:52,427 --> 01:13:52,961 >> THE NEXT CONCEPT IS THE 1227 01:13:52,961 --> 01:13:59,968 IMPACT OF STRESSORS ON THE 1228 01:13:59,968 --> 01:14:00,569 BIOLOGICAL MECHANISMS OF AGING 1229 01:14:00,569 --> 01:14:01,170 AND OTHER ASSOCIATED OUTCOMES 1230 01:14:01,170 --> 01:14:06,775 AND EXPERIMENTAL MODEL SYSTEMS. 1231 01:14:06,775 --> 01:14:07,376 DOCTOR MANLEY PLEASE DESCRIBE 1232 01:14:07,376 --> 01:14:07,976 THE CONCEPT AND DISCUSSION. 1233 01:14:07,976 --> 01:14:13,582 >> YES THIS CONCEPT CLEARANCE 1234 01:14:13,582 --> 01:14:19,488 PROVIDES A RATIONALE FOR A SET 1235 01:14:19,488 --> 01:14:20,022 OF APPLICATION THROUGH THE 1236 01:14:20,022 --> 01:14:24,226 MECHANISM CALLED ARE 61, OR 33 1237 01:14:24,226 --> 01:14:27,596 APPLICATION. 1238 01:14:27,596 --> 01:14:28,163 AND THE GOAL IS TO HAVE THE 1239 01:14:28,163 --> 01:14:37,573 IMPACT OF MIDLIFE STRESSORS WITH 1240 01:14:37,573 --> 01:14:38,207 AN EXPERIMENTAL MODEL SYSTEM MAY 1241 01:14:38,207 --> 01:14:38,807 ALREADY KNOW PRETTY WELL THAT 1242 01:14:38,807 --> 01:14:39,675 EXTERNAL STRESSORS CAN AFFECT 1243 01:14:39,675 --> 01:14:46,148 HEALTH AND ACCELERATE IN 1244 01:14:46,148 --> 01:14:46,748 BIOLOGICAL AGING THAT MOST OF 1245 01:14:46,748 --> 01:14:48,116 THE STUDIES PROVIDING THIS 1246 01:14:48,116 --> 01:14:49,418 FOUNDATION ARE EITHER 1247 01:14:49,418 --> 01:14:53,121 OBSERVATIONAL OR WITH THE 1248 01:14:53,121 --> 01:14:57,226 EXPERIMENTAL SETTINGS TO FOCUS 1249 01:14:57,226 --> 01:14:59,761 ON EXPOSURES AND SHORT-TERM 1250 01:14:59,761 --> 01:15:03,031 OUTCOMES. 1251 01:15:03,031 --> 01:15:04,032 AND ARE IN TIGHTLY CONTROLLED 1252 01:15:04,032 --> 01:15:08,003 CONDITIONS. 1253 01:15:08,003 --> 01:15:16,612 SO BIOLOGICAL HALLMARKS OF AGING 1254 01:15:16,612 --> 01:15:22,384 AND THEN BY THE MODEL SYSTEMS 1255 01:15:22,384 --> 01:15:23,418 THAT IN VITRO SYSTEM BUT ALSO 1256 01:15:23,418 --> 01:15:26,722 LABORATORY IN TO BE 1257 01:15:26,722 --> 01:15:28,957 CHARACTERIZED WERE DOMESTICATED 1258 01:15:28,957 --> 01:15:31,893 WITH POPULATIONS. 1259 01:15:31,893 --> 01:15:36,331 THE EXPERIMENTS WITHIN THOSE 1260 01:15:36,331 --> 01:15:45,741 POPULATIONS ARE TIGHTLY 1261 01:15:45,741 --> 01:15:46,041 CONTROLLED. 1262 01:15:46,041 --> 01:15:46,575 BUT THAT'S NOT THE WAY IT 1263 01:15:46,575 --> 01:15:47,175 HAPPENS IN THE REAL WORLD WITH 1264 01:15:47,175 --> 01:15:50,779 THOSE INTERACTIONS ARE BETWEEN 1265 01:15:50,779 --> 01:15:51,046 STRESSORS. 1266 01:15:51,046 --> 01:15:51,680 THESE INTERACTIONS ARE IMPORTANT 1267 01:15:51,680 --> 01:15:56,351 TO UNDERSTAND TO KNOW IF IT 1268 01:15:56,351 --> 01:16:00,122 OCCURS IN MIDLIFE. 1269 01:16:00,122 --> 01:16:07,362 THE WORKSHOP APRIL 2023 AND WITH 1270 01:16:07,362 --> 01:16:10,165 THE HALLMARKS OF AGING AND 1271 01:16:10,165 --> 01:16:15,404 OPENING THE WAY FOR POST 1272 01:16:15,404 --> 01:16:25,881 DEVELOPMENT STRESSORS SO TO 1273 01:16:26,481 --> 01:16:29,584 UNDERSTAND THE MALLEABLE 1274 01:16:29,584 --> 01:16:33,255 PROCESSES. 1275 01:16:33,255 --> 01:16:34,790 AND WITH THAT TWO-PHASE 1276 01:16:34,790 --> 01:16:40,962 APPLICATION AND THE SECOND PHASE 1277 01:16:40,962 --> 01:16:41,663 IS CONTINGENT ON ADMINISTRATIVE 1278 01:16:41,663 --> 01:16:51,807 REVIEW. 1279 01:16:52,307 --> 01:16:52,841 AND THE NOFO WORD HAVE STUDIES 1280 01:16:52,841 --> 01:16:54,876 TESTING STRESSORS IN A SINGLE 1281 01:16:54,876 --> 01:16:56,545 MODEL SYSTEM OR MULTIPLE MODEL 1282 01:16:56,545 --> 01:17:00,582 SYSTEMS. 1283 01:17:00,582 --> 01:17:05,153 THE APPLICATION ORIGINALLY 1284 01:17:05,153 --> 01:17:11,660 ENCOURAGE MULTIDISCIPLINARY 1285 01:17:11,660 --> 01:17:12,227 DISCUSSIONS WHETHER JUST BY 1286 01:17:12,227 --> 01:17:14,329 VIRTUE OF THAT BEING A CRITICAL 1287 01:17:14,329 --> 01:17:19,301 ROLE AND WHETHER THE IS 1288 01:17:19,301 --> 01:17:23,038 ENCOURAGED AND IT SHOULD BE 1289 01:17:23,038 --> 01:17:30,278 REQUIRED AND IN ADDITION TO 1290 01:17:30,278 --> 01:17:32,514 AGREE WITH THE IMPORTANCE OF 1291 01:17:32,514 --> 01:17:37,285 THIS FUNDING APPLICATION THERE 1292 01:17:37,285 --> 01:17:38,754 IS ALSO DISCUSSION OF A MISSED 1293 01:17:38,754 --> 01:17:45,861 OPPORTUNITY WITHIN THE NOFO 1294 01:17:45,861 --> 01:17:46,461 BETWEEN HEALTH DISPARITIES AND 1295 01:17:46,461 --> 01:17:50,399 THE STRESSORS THAT MIGHT BE 1296 01:17:50,399 --> 01:17:51,700 STUDIED WE TALKED ABOUT HOW 1297 01:17:51,700 --> 01:17:56,338 DIFFICULT IT IS TO PUT THE HUMAN 1298 01:17:56,338 --> 01:18:01,343 WORLD OF DISPARITIES INTO THE 1299 01:18:01,343 --> 01:18:02,744 ANIMAL WORLD OF STRESSORS BUT 1300 01:18:02,744 --> 01:18:06,381 ULTIMATELY THERE MAY BE 1301 01:18:06,381 --> 01:18:15,323 OPPORTUNITIES TO THINK ABOUT 1302 01:18:15,323 --> 01:18:15,991 THAT AND HAVE THAT BE A PART OF 1303 01:18:15,991 --> 01:18:19,961 THE APPLICATION. 1304 01:18:19,961 --> 01:18:20,595 SO WITH THAT WE ENTHUSIASTICALLY 1305 01:18:20,595 --> 01:18:29,271 SUPPORT THIS CONCEPT. 1306 01:18:29,271 --> 01:18:29,871 >> WE WILL MOVE ON TO THE NEXT 1307 01:18:29,871 --> 01:18:37,179 SET OF CONCEPTS. 1308 01:18:37,179 --> 01:18:37,712 SAID ON INTERDISCIPLINARY 1309 01:18:37,712 --> 01:18:38,313 BEHAVIOR FOCUSED ON PROMOTING 1310 01:18:38,313 --> 01:18:39,781 THE USE OF THE NIH STAGE MODEL 1311 01:18:39,781 --> 01:18:44,152 AND COGNITIVE DATA FROM THE 1312 01:18:44,152 --> 01:18:44,786 HEALTH AND RETIREMENT STUDY AND 1313 01:18:44,786 --> 01:18:45,587 TO HARMONIZE COGNITIVE 1314 01:18:45,587 --> 01:18:51,593 ASSESSMENT PROTOCOL ON AGING FOR 1315 01:18:51,593 --> 01:18:57,499 CROSS NATIONAL DATA ANALYSIS. 1316 01:18:57,499 --> 01:19:08,009 PLEASE SUMMARIZE THE CONCEPT. 1317 01:19:10,212 --> 01:19:10,779 >> THANK YOU IT IS A PROPOSAL TO 1318 01:19:10,779 --> 01:19:11,413 USE THE R 25 MECHANISM USED IN A 1319 01:19:11,413 --> 01:19:12,047 NUMBER OF DIFFERENT WAYS BUT TO 1320 01:19:12,047 --> 01:19:15,951 USE IT TO ADVANCE RESEARCH IN 1321 01:19:15,951 --> 01:19:21,089 SPECIFIC AREAS WHERE NIA IS 1322 01:19:21,089 --> 01:19:21,690 INVESTING IN OPPORTUNITIES OR 1323 01:19:21,690 --> 01:19:27,829 HAS A DESIRE TO EXPAND A 1324 01:19:27,829 --> 01:19:34,936 FRAMEWORK IT IS A BLUEPRINT WITH 1325 01:19:34,936 --> 01:19:37,439 INTERVENTION TRIALS AND THE IDEA 1326 01:19:37,439 --> 01:19:39,307 TO THINK ABOUT BEHAVIORAL 1327 01:19:39,307 --> 01:19:39,975 INTERVENTIONS TO WORK WITH AND 1328 01:19:39,975 --> 01:19:47,949 THAT MODEL AND THEIR PLANS. 1329 01:19:47,949 --> 01:19:51,186 AND THE OTHER TOPIC IS TRAINED 1330 01:19:51,186 --> 01:19:56,258 TO DO SECONDARY ANALYSIS WITH 1331 01:19:56,258 --> 01:20:00,595 THE INTERNATIONAL COMMUNITY AND 1332 01:20:00,595 --> 01:20:03,131 THOSE CASE STUDIES THAT HAVE 1333 01:20:03,131 --> 01:20:07,202 RICHER MEASUREMENT. 1334 01:20:07,202 --> 01:20:07,802 THERE ARE GREAT OPPORTUNITIES 1335 01:20:07,802 --> 01:20:13,341 FOR INNOVATIVE RESEARCH BECAUSE 1336 01:20:13,341 --> 01:20:13,975 WHAT MOST OF THE STUDIES HAVE IN 1337 01:20:13,975 --> 01:20:14,743 THE POLICY VARIATIONS ACROSS 1338 01:20:14,743 --> 01:20:18,446 DIFFERENT CONTEXT AND NATIONAL 1339 01:20:18,446 --> 01:20:22,284 ANALYSIS OFFERS POTENTIAL TO 1340 01:20:22,284 --> 01:20:26,321 LEARN NEW THINGS SO WITH THE 1341 01:20:26,321 --> 01:20:28,857 ENTHUSIASM FOR BOTH OF THESE IT 1342 01:20:28,857 --> 01:20:34,095 IS SO DIFFERENT TO REQUIRE SUCH 1343 01:20:34,095 --> 01:20:36,231 A DIFFERENT SET UP AND DESIGN 1344 01:20:36,231 --> 01:20:45,106 FOR STUDENTS TO BE RECRUITED WE 1345 01:20:45,106 --> 01:20:45,674 FELT THEY SHOULD BE SEPARATE 1346 01:20:45,674 --> 01:20:46,274 FUNDING OPPORTUNITIES AND NOT 1347 01:20:46,274 --> 01:20:48,944 TRY TO SQUEEZE THEM INTO 1 THAT 1348 01:20:48,944 --> 01:20:51,246 WERE NOT ADEQUATELY ADDRESS 1349 01:20:51,246 --> 01:21:01,590 EITHER SPECIFICALLY. 1350 01:21:02,490 --> 01:21:03,024 >> WE WILL MOVE ON TO THE NEXT 1351 01:21:03,024 --> 01:21:11,633 GROUP WITH THE TRANSLATIONAL 1352 01:21:11,633 --> 01:21:12,233 AGING RESEARCH PRECLINICAL AND 1353 01:21:12,233 --> 01:21:14,169 EARLY PHASE HUMAN STUDIES. 1354 01:21:14,169 --> 01:21:21,843 PLEASE PRESENT THE CONCEPT 1355 01:21:21,843 --> 01:21:22,177 DOCTOR BAKER. 1356 01:21:22,177 --> 01:21:22,811 >> THIS PARTICULAR CONCEPT IS BY 1357 01:21:22,811 --> 01:21:24,479 THE TRANSLATION RESEARCH WORKING 1358 01:21:24,479 --> 01:21:31,853 GROUP THAT IS THE YOU AGE 2 AND 1359 01:21:31,853 --> 01:21:33,722 3 TO SUPPORT CATEGORIES OF 1360 01:21:33,722 --> 01:21:36,224 PROJECTS IN THE CONVENTIONAL 1361 01:21:36,224 --> 01:21:39,260 PATHWAY SUCH AS CHEMICAL 1362 01:21:39,260 --> 01:21:41,529 MOLECULAR ENTITIES WITH ENTRY 1363 01:21:41,529 --> 01:21:51,840 POINTS SUCH AS SCREENING AND 1364 01:21:51,840 --> 01:21:52,440 THROUGH LATE STAGE PRECLINICAL 1365 01:21:52,440 --> 01:21:53,008 DEVELOPMENT AND THE SECOND 1366 01:21:53,008 --> 01:21:58,913 APPROACH THROUGH DATA DRIVEN 1367 01:21:58,913 --> 01:21:59,514 THROUGH SUBSEQUENT VALIDATION 1368 01:21:59,514 --> 01:22:00,115 WITH THE GENERATION PROOF OF 1369 01:22:00,115 --> 01:22:05,654 CONCEPT DATA WITH IN VIVO AND IN 1370 01:22:05,654 --> 01:22:09,624 VITRO EXPERIMENTAL SYSTEMS AND 1371 01:22:09,624 --> 01:22:13,194 THEN THE INVESTIGATIVE TEAMS 1372 01:22:13,194 --> 01:22:15,930 WITH MULTIDISCIPLINARY WITH THE 1373 01:22:15,930 --> 01:22:19,934 TRANSLATIONAL RESEARCH PROJECT 1374 01:22:19,934 --> 01:22:22,370 THROUGH THE PIPELINE THROUGH 1375 01:22:22,370 --> 01:22:26,041 BASIC COMPUTATIONAL MEDICINAL 1376 01:22:26,041 --> 01:22:32,180 CHEMISTRY AND PRECLINICAL DRUG 1377 01:22:32,180 --> 01:22:32,647 DEVELOPMENT EXPERTISE. 1378 01:22:32,647 --> 01:22:33,448 SO OBVIOUSLY THIS IS 1379 01:22:33,448 --> 01:22:42,257 MULTIDISCIPLINARY WITH THOSE 1380 01:22:42,257 --> 01:22:42,857 THAT ARE POTENTIALLY ACADEMIC 1381 01:22:42,857 --> 01:22:43,391 AND NONPROFIT ENTITIES TO 1382 01:22:43,391 --> 01:22:43,858 ACHIEVE THE REQUISITE 1383 01:22:43,858 --> 01:22:44,125 EXPERTISE. 1384 01:22:44,125 --> 01:22:50,165 ULTIMATELY THE COMMITTEE FELT 1385 01:22:50,165 --> 01:22:50,765 THE TOPICS WERE VERY RELEVANT 1386 01:22:50,765 --> 01:22:55,937 FOR AGE-RELATED RESEARCH. 1387 01:22:55,937 --> 01:22:56,538 IT'S VERY IMPORTANT FOR MOVING 1388 01:22:56,538 --> 01:22:57,138 THINGS INTO THE NEXT STAGE WE 1389 01:22:57,138 --> 01:23:01,009 CAN THINK ABOUT WITH SOME TYPE 1390 01:23:01,009 --> 01:23:04,612 OF CLINICAL UTILITY AND TO BE 1391 01:23:04,612 --> 01:23:07,082 SUPPORTIVE OF THIS PARTICULAR 1392 01:23:07,082 --> 01:23:10,251 CONCEPT. 1393 01:23:10,251 --> 01:23:11,286 >> THE NEXT CONCEPT IS RENEWAL 1394 01:23:11,286 --> 01:23:14,422 OF GRANTS FOR EARLY MEDICAL 1395 01:23:14,422 --> 01:23:16,758 SURGICAL SPECIALIST TRANSITION 1396 01:23:16,758 --> 01:23:23,164 TO AGING RESEARCH. 1397 01:23:23,164 --> 01:23:24,699 PLEASE PRESENT THE CONCEPT AND 1398 01:23:24,699 --> 01:23:25,734 DISCUSSION. 1399 01:23:25,734 --> 01:23:36,277 >> GEMSSTAR IS WITH ESTABLISHING 1400 01:23:41,850 --> 01:23:42,350 A TRACK RECORD IN A FOCUSED 1401 01:23:42,350 --> 01:23:42,751 RESEARCH ON AGING. 1402 01:23:42,751 --> 01:23:47,489 THE OVERALL GOAL IS TO ENCOURAGE 1403 01:23:47,489 --> 01:23:47,956 THEM TO HAVE LONG-TERM 1404 01:23:47,956 --> 01:23:50,825 COMMITMENT TO THE AGING FIELD AS 1405 01:23:50,825 --> 01:23:55,130 WELL AS PURSUE CAREER A RESEARCH 1406 01:23:55,130 --> 01:24:01,236 FOCUSED CAREER ON AGING RESEA 1407 01:24:01,236 --> 01:24:01,603 RESEARCH. 1408 01:24:01,603 --> 01:24:06,474 IT PROVIDES A MECHANISM GRANT AT 1409 01:24:06,474 --> 01:24:11,646 THE SECTION IS AGING WITH 1410 01:24:11,646 --> 01:24:14,115 PRIMARY CLINICAL SPECIALTY AND 1411 01:24:14,115 --> 01:24:16,851 ALSO PROFESSIONAL DEVELOPMENT 1412 01:24:16,851 --> 01:24:22,090 PLAN AND ALSO A CONFERENCE THAT 1413 01:24:22,090 --> 01:24:28,930 IS PROVIDED TO PROVIDE SUPPORT 1414 01:24:28,930 --> 01:24:31,466 AS THE HIGH POINTS OF THE 1415 01:24:31,466 --> 01:24:35,036 PROGRAM THEY HAVE BEEN IN PLACE 1416 01:24:35,036 --> 01:24:42,744 NOW FOR YEARS TO HELP LAUNCH THE 1417 01:24:42,744 --> 01:24:44,846 CAREERS OF 221 AND IT HAS BEEN 1418 01:24:44,846 --> 01:24:51,352 VERY SUCCESSFUL AND RESEARCH 1419 01:24:51,352 --> 01:24:55,757 CAREERS AND SUCCESSFUL ACADEMIC 1420 01:24:55,757 --> 01:24:57,992 AND LEADERSHIP ROLES IN THEIR 1421 01:24:57,992 --> 01:25:02,597 FIELDS ON THE DISCUSSION WITH 1422 01:25:02,597 --> 01:25:09,938 THE SUPPORT FOR THE PROGRAM AND 1423 01:25:09,938 --> 01:25:10,505 NO QUESTION THAT WAS HIGHLY 1424 01:25:10,505 --> 01:25:11,206 SUCCESSFUL THERE WERE SOME 1425 01:25:11,206 --> 01:25:12,540 RECOMMENDATIONS PROVIDED TO TRY 1426 01:25:12,540 --> 01:25:23,084 TO ENHANCE THAT TRAINING THAT IS 1427 01:25:24,853 --> 01:25:30,592 PROVIDED AND THEN TO ENSURE 1428 01:25:30,592 --> 01:25:40,835 ADEQUATE PROJECT SUPPORT THAN 1429 01:25:40,835 --> 01:25:41,469 THE GRANTS TO BE USED FOR SALARY 1430 01:25:41,469 --> 01:25:42,003 SUPPORT AND CONTINUING TO 1431 01:25:42,003 --> 01:25:42,637 ENHANCE THE PROGRAM RESPONSE OF 1432 01:25:42,637 --> 01:25:43,271 FEEDBACK TO THE CANDIDATES AND 1433 01:25:43,271 --> 01:25:49,444 TO ASSURE DIVERSITY. 1434 01:25:49,444 --> 01:25:52,647 THANK YOU SO MUCH. 1435 01:25:52,647 --> 01:26:03,191 >> THE NEXT CONCEPT IS MENTORED 1436 01:26:07,562 --> 01:26:07,962 CAREER DEVELOPMENT AND 1437 01:26:07,962 --> 01:26:08,596 ENHANCEMENT AWARD TO BUILD CROSS 1438 01:26:08,596 --> 01:26:09,130 DISCIPLINARY KNOWLEDGE AND 1439 01:26:09,130 --> 01:26:12,166 SKILLS FOR COMPARATIVE STUDIES 1440 01:26:12,166 --> 01:26:12,767 OF HUMAN AND NONHUMAN PRIMATE 1441 01:26:12,767 --> 01:26:13,234 SPECIES WITH DIFFERING 1442 01:26:13,234 --> 01:26:17,538 LIFESPANS. 1443 01:26:17,538 --> 01:26:19,841 DOCTOR PETERSON PLEASE PRESENT 1444 01:26:19,841 --> 01:26:21,009 THE COMMENTS. 1445 01:26:21,009 --> 01:26:23,511 >> THIS CONCEPT IS AIMED AT 1446 01:26:23,511 --> 01:26:32,987 DEVELOPING AND ATTRACTING BOTH 1447 01:26:32,987 --> 01:26:33,621 EARLY CAREER SCIENTIST TO EXPAND 1448 01:26:33,621 --> 01:26:35,523 THE NUMBER OF INVESTIGATORS 1449 01:26:35,523 --> 01:26:37,692 ACROSS BASIC SCIENCE AND 1450 01:26:37,692 --> 01:26:39,961 VETERINARY SCIENCE AND CLINICAL 1451 01:26:39,961 --> 01:26:42,797 SCIENCE IT IS EXPERTISE THAT 1452 01:26:42,797 --> 01:26:47,969 THAT COMPARATIVE STUDY THAT 1453 01:26:47,969 --> 01:26:48,569 CONTRIBUTES TO DIFFERENCES IN 1454 01:26:48,569 --> 01:26:53,007 LIFESPANS IF YOU LOOK AT PRIMATE 1455 01:26:53,007 --> 01:26:58,680 SPECIES THE LIFESPAN IS 1456 01:26:58,680 --> 01:26:59,213 TREMENDOUS AND WE WENT TO 1457 01:26:59,213 --> 01:27:00,548 UNDERSTAND THAT AS A GOAL OF THE 1458 01:27:00,548 --> 01:27:05,153 NEW INITIATIVE. 1459 01:27:05,153 --> 01:27:07,922 2 DIFFERENT TARGETED RESEARCH 1460 01:27:07,922 --> 01:27:12,760 WORKS WERE REQUESTED 1 IS FOR 1461 01:27:12,760 --> 01:27:18,633 VERY EARLY CAREER INVESTIGATORS 1462 01:27:18,633 --> 01:27:22,537 AND THEN THE SECOND TO REQUESTED 1463 01:27:22,537 --> 01:27:26,374 IS MORE MID-LEVEL TO COME INTO 1464 01:27:26,374 --> 01:27:31,779 THE FIELD OF AGING AND THE FIELD 1465 01:27:31,779 --> 01:27:32,647 OF AGING THROUGH RESEARCH CAREER 1466 01:27:32,647 --> 01:27:37,885 ENHANCEMENT AWARD. 1467 01:27:37,885 --> 01:27:44,258 AS I SAID THE GERONTOLOGY 1468 01:27:44,258 --> 01:27:47,695 DIVISION WAS AT THIS BUT THE 1469 01:27:47,695 --> 01:27:50,164 OTHER 3 DIVISIONS ARE SUPPORTIVE 1470 01:27:50,164 --> 01:27:54,469 AND A PART OF THIS REQUEST. 1471 01:27:54,469 --> 01:28:04,012 THIS AREA IS COMPLEX AND 1472 01:28:04,012 --> 01:28:04,278 EXCITING. 1473 01:28:04,278 --> 01:28:04,812 THE RANGE OF THE POTENTIAL 1474 01:28:04,812 --> 01:28:05,446 CONTRIBUTORS TO THE DIFFERENCES 1475 01:28:05,446 --> 01:28:06,881 OF PRIMATE SPECIES LIFESPANS 1476 01:28:06,881 --> 01:28:10,184 REQUIRE EXPERIENCE AND EXPERTISE 1477 01:28:10,184 --> 01:28:13,855 SUCH A BROAD ARRAY OF AREAS 1478 01:28:13,855 --> 01:28:16,391 INCLUDING RESEARCHERS AND HUMAN 1479 01:28:16,391 --> 01:28:19,827 LONGEVITY AND COMPARATIVE 1480 01:28:19,827 --> 01:28:23,097 BIOLOGY, EVOLUTIONARY 1481 01:28:23,097 --> 01:28:27,702 GENETICS, ANTHROPOLOGY, AS WELL 1482 01:28:27,702 --> 01:28:28,269 AS BASIC CLINICAL SCIENTIST 1483 01:28:28,269 --> 01:28:32,507 ALREADY IN THE FIELD OF AGING. 1484 01:28:32,507 --> 01:28:39,113 AND THIS IS REQUIRED TO DEVELOP 1485 01:28:39,113 --> 01:28:45,086 TO IDENTIFY CONTRIBUTING FACT 1486 01:28:45,086 --> 01:28:45,386 FACTORS. 1487 01:28:45,386 --> 01:28:49,390 THE REQUEST FOR THESE AWARDS 1488 01:28:49,390 --> 01:28:52,060 COMPLEMENT THOSE THAT WERE 1489 01:28:52,060 --> 01:29:00,368 ISSUED FISCAL YEAR 24 AND 1490 01:29:00,368 --> 01:29:00,868 APPROVED BY THE COUNCIL 1491 01:29:00,868 --> 01:29:09,510 PREVIOUSLY AND THAT IS 1 IN THE 1492 01:29:09,510 --> 01:29:11,913 NEW AREA OF COMPARATIVE PRIMATE 1493 01:29:11,913 --> 01:29:13,748 BIOLOGY THAT IS APPROVED AND 1494 01:29:13,748 --> 01:29:18,119 REQUESTED AND THEN THE SECOND 1495 01:29:18,119 --> 01:29:21,589 RFA DESIGNED TO FUND THE 1496 01:29:21,589 --> 01:29:24,325 INFRASTRUCTURE GRANT THAT IS 1497 01:29:24,325 --> 01:29:26,894 NETWORKING TO HELP COORDINATE 1498 01:29:26,894 --> 01:29:34,902 THOSE FUNDED R 01. 1499 01:29:34,902 --> 01:29:35,470 SO THE COUNCIL IN GENERAL IS 1500 01:29:35,470 --> 01:29:38,506 VERY SUPPORTIVE AND IT'S 1501 01:29:38,506 --> 01:29:44,846 ESSENTIAL FROM ALL OF THE 1502 01:29:44,846 --> 01:29:45,413 RELEVANT DIFFERENT AREAS OF 1503 01:29:45,413 --> 01:29:52,787 BIOLOGY MANY OF WHOM WERE NOT 1504 01:29:52,787 --> 01:29:53,387 NORMALLY THINK OF AN AGE IS A 1505 01:29:53,387 --> 01:29:58,159 PARTICULAR FUNDING SOURCE THIS 1506 01:29:58,159 --> 01:29:59,127 IS THE IDEA UNNECESSARY THAT THE 1507 01:29:59,127 --> 01:30:01,929 AN EYE HAS -- -- HAVE IN THOSE 1508 01:30:01,929 --> 01:30:04,932 METHODS TO ATTRACT PEOPLE IN 1509 01:30:04,932 --> 01:30:08,636 DIFFERENT FIELDS. 1510 01:30:08,636 --> 01:30:09,170 THIS REQUIRES BUILDING THE 1511 01:30:09,170 --> 01:30:15,376 INTERDISCIPLINARY RESEARCH TEAM 1512 01:30:15,376 --> 01:30:15,977 AND THEN TO BE VERY SUPPORTIVE 1513 01:30:15,977 --> 01:30:18,613 OF THIS IDEA TO BUILD THE 1514 01:30:18,613 --> 01:30:25,453 PRIMATE BIOLOGY AND LONGEVITY. 1515 01:30:25,453 --> 01:30:25,987 IT IS VERY EARLY ON IN THE 1516 01:30:25,987 --> 01:30:27,855 DEVELOPMENT OF THIS FIELD THAT 1517 01:30:27,855 --> 01:30:31,993 THE RF A 4801 HAVE THE POTENTIAL 1518 01:30:31,993 --> 01:30:35,296 TO BUILD THE FOUNDATION FOR THE 1519 01:30:35,296 --> 01:30:36,697 NEW FIELD AND PROVIDE 1520 01:30:36,697 --> 01:30:38,900 INFRASTRUCTURE TO ALLOW 1521 01:30:38,900 --> 01:30:41,135 INVESTIGATORS TO DEVELOP THEIR 1522 01:30:41,135 --> 01:30:46,307 OWN DISCIPLINARY TEAMS BUT WE 1523 01:30:46,307 --> 01:30:48,709 FELT AS A TEAM AND WHAT WE 1524 01:30:48,709 --> 01:30:54,315 DISCUSSED BECAUSE THIS IS A NEW 1525 01:30:54,315 --> 01:31:04,859 AREA AND WITH THAT WE THOUGHT IT 1526 01:31:07,995 --> 01:31:08,763 MIGHT BE PREMATURE TO THINK A 1527 01:31:08,763 --> 01:31:12,767 YOUNG INVESTIGATOR IN THE AREA 1528 01:31:12,767 --> 01:31:13,801 OUTSIDE OF THIS COULD IN FACT 1529 01:31:13,801 --> 01:31:23,811 RIGHT NOW WITH NO INFRASTRUCTURE 1530 01:31:23,811 --> 01:31:24,445 TO DO INTERDISCIPLINARY TEAMS TO 1531 01:31:24,445 --> 01:31:34,922 REACH OUT TO OTHER AREAS AND 1532 01:31:35,923 --> 01:31:36,424 HAVING A TRACK RECORD SO WE 1533 01:31:36,424 --> 01:31:37,725 THOUGHT THAT 1 POSSIBILITY WOULD 1534 01:31:37,725 --> 01:31:47,168 BE TO SPLIT THIS INTO 2 SO NOW 1535 01:31:47,168 --> 01:31:48,135 IT IS ISSUED FOR THE MIDCAREER 1536 01:31:48,135 --> 01:31:48,736 FOR ESTABLISHED INVESTIGATORS 1537 01:31:48,736 --> 01:31:53,708 WHO WANT TO BROADEN OUT INTO 1538 01:31:53,708 --> 01:31:54,308 PRIMATE BIOLOGY WHILE ALLOWING 1539 01:31:54,308 --> 01:31:58,546 THE FIELD TO DEVELOP SO THERE IS 1540 01:31:58,546 --> 01:32:07,321 A FOUNDATION AND THOSE COULD 1541 01:32:07,321 --> 01:32:08,856 THOSE COLLABORATIVE 1542 01:32:08,856 --> 01:32:11,259 OPPORTUNITIES AS PEOPLE BECOME 1543 01:32:11,259 --> 01:32:13,094 ESTABLISHED IT MIGHT BE WISE TO 1544 01:32:13,094 --> 01:32:23,604 HOLD OFF ON THOSE AND THEN TO 1545 01:32:26,107 --> 01:32:26,641 DEVELOP TO PUT MORE SUPPORT ON 1546 01:32:26,641 --> 01:32:27,508 THESE INVESTIGATORS TO ESTABLISH 1547 01:32:27,508 --> 01:32:27,975 THE INTERDISCIPLINARY 1548 01:32:27,975 --> 01:32:38,319 COLLABORATIVE TEAMS. 1549 01:32:48,729 --> 01:32:49,297 >> THANK YOU FOR REVIEWING THAT 1550 01:32:49,297 --> 01:32:49,930 AND THE CONCEPT OF THE COMMENTS 1551 01:32:49,930 --> 01:32:50,464 UP NEXT UNDERSTANDING THE 1552 01:32:50,464 --> 01:32:51,032 MECHANISMS WITH AGE-RELATED 1553 01:32:51,032 --> 01:32:52,833 CHANGES WITH THE BIOMECHANICS 1554 01:32:52,833 --> 01:32:53,834 INCREASING THE METABOLIC COST OF 1555 01:32:53,834 --> 01:32:59,140 WALKING. 1556 01:32:59,140 --> 01:33:04,812 SO BECAUSE MOBILITY AND 1557 01:33:04,812 --> 01:33:05,346 DYSFUNCTION TALKS ABOUT A 1558 01:33:05,346 --> 01:33:07,114 QUARTER OF THOSE OVER THE AGE OF 1559 01:33:07,114 --> 01:33:09,650 65 REPRESENTS A MAJOR HEALTH 1560 01:33:09,650 --> 01:33:11,652 PROBLEM AND THEN TO BE 1561 01:33:11,652 --> 01:33:18,359 ASSOCIATED STRENGTH, POWER 1562 01:33:18,359 --> 01:33:20,027 BALANCE, JOINT MOBILITY AND ALL 1563 01:33:20,027 --> 01:33:25,900 OF THAT WILL IMPACT BIOMECHANICS 1564 01:33:25,900 --> 01:33:26,500 BARRIER TO EFFECTIVE TARGETING 1565 01:33:26,500 --> 01:33:31,872 FOR PREVENTION HAS BEEN A LACK 1566 01:33:31,872 --> 01:33:40,581 OF UNDERSTANDING ON THESE 1567 01:33:40,581 --> 01:33:41,048 RELATED CHANGES OF THE 1568 01:33:41,048 --> 01:33:41,549 NEUROMUSCULAR AND MUSCLE 1569 01:33:41,549 --> 01:33:43,918 SYSTEMS. 1570 01:33:43,918 --> 01:33:51,192 TO ADDRESS THE RESEARCH GAPS 1571 01:33:51,192 --> 01:33:51,592 LEADING A WORKSHOP 1572 01:33:51,592 --> 01:33:52,259 SEPTEMBER 2021 THAT LED TO THE 1573 01:33:52,259 --> 01:33:54,161 CURRENT RFA. 1574 01:33:54,161 --> 01:33:58,299 SUPPORTING RESEARCH STUDIES 1575 01:33:58,299 --> 01:34:03,170 USING THE R 01 MECHANISM WITH 1576 01:34:03,170 --> 01:34:06,674 MULTIDISCIPLINARY TEAMS TO 1577 01:34:06,674 --> 01:34:07,908 EMPLOY COMPLEX INNOVATIVE 1578 01:34:07,908 --> 01:34:13,814 APPROACHES SPECIFICALLY 1579 01:34:13,814 --> 01:34:14,382 SUPPORTING STUDIES TO BETTER 1580 01:34:14,382 --> 01:34:14,915 UNDERSTAND THE MECHANISMS 1581 01:34:14,915 --> 01:34:22,356 UNDERLYING COMPENSATORY POSTURE 1582 01:34:22,356 --> 01:34:22,957 STRATEGIES THAT CONTRIBUTE TO 1583 01:34:22,957 --> 01:34:23,491 SLOWER WALKING SPEED AND 1584 01:34:23,491 --> 01:34:23,824 FATIGABILITY. 1585 01:34:23,824 --> 01:34:26,660 THE GOAL WAS TO EXAMINE MULTIPLE 1586 01:34:26,660 --> 01:34:30,664 SYSTEMS INCLUDING 1587 01:34:30,664 --> 01:34:33,067 MUSCLES, TENDONS AND THE AREAS 1588 01:34:33,067 --> 01:34:38,506 OF INTEREST INCLUDE THE EFFECTS 1589 01:34:38,506 --> 01:34:38,939 OF CNS AND MUSCULAR 1590 01:34:38,939 --> 01:34:47,047 CHANGES, SCALE IT OR 1591 01:34:47,047 --> 01:34:47,581 COMPUTATIONAL MODELING AND 1592 01:34:47,581 --> 01:34:48,215 SIMULATION AND CHANGES OF TISSUE 1593 01:34:48,215 --> 01:34:50,184 STRUCTURE AND FUNCTION. 1594 01:34:50,184 --> 01:34:51,719 THE COLLABORATIONS ARE 1595 01:34:51,719 --> 01:34:56,090 ENCOURAGED WITH NO INTER- 1596 01:34:56,090 --> 01:34:56,857 DIVISION ARE PART OF THE 1597 01:34:56,857 --> 01:34:57,458 PROPOSAL A JUSTIFICATION WOULD 1598 01:34:57,458 --> 01:35:02,863 BE NEEDED THIS WAS IMPORTANT AND 1599 01:35:02,863 --> 01:35:13,407 TIMELY THAT IS A COSTLY PROBLEM 1600 01:35:22,183 --> 01:35:23,150 AND KEY TO THE SUCCESS OF THE 1601 01:35:23,150 --> 01:35:23,651 PROPOSAL AND TO BE VERY 1602 01:35:23,651 --> 01:35:30,024 ENTHUSIASTIC MOVING FORWARD. 1603 01:35:30,024 --> 01:35:32,560 WE WILL GO AHEAD WITH THE NEXT 1604 01:35:32,560 --> 01:35:39,099 CONCEPT REGARDING THE RENEWAL OF 1605 01:35:39,099 --> 01:35:39,733 THE UPPER OLDER AMERICAN 1606 01:35:39,733 --> 01:35:41,101 INDEPENDENT CENTERS. 1607 01:35:41,101 --> 01:35:47,007 PLEASE PRESENT THE CONCEPT. 1608 01:35:47,007 --> 01:35:55,616 >> TO IS CONCEPT WITH THE END OR 1609 01:35:55,616 --> 01:35:56,417 PARENT -- -- INDEPENDENT OLDER 1610 01:35:56,417 --> 01:36:02,022 AMERICANS CENTER PROGRAM IT IS 1611 01:36:02,022 --> 01:36:02,556 SUPPORTED BY THE OCCURRING 1612 01:36:02,556 --> 01:36:03,424 GRANTS IN EXISTENCE FOR DECADES 1613 01:36:03,424 --> 01:36:04,758 AND TO FOCUS THE RESEARCH ON THE 1614 01:36:04,758 --> 01:36:12,399 PHYSICAL INDEPENDENCE. 1615 01:36:12,399 --> 01:36:13,000 IT IS WELL DOCUMENTED THE LOSS 1616 01:36:13,000 --> 01:36:13,634 OF MOBILITY AND VARIOUS DISEASES 1617 01:36:13,634 --> 01:36:15,503 THAT AFFECT THE ABILITY AND 1618 01:36:15,503 --> 01:36:17,137 SIGNIFICANTLY REDUCE THE QUALITY 1619 01:36:17,137 --> 01:36:23,811 OF LIFE AND ALSO HAVE 1620 01:36:23,811 --> 01:36:29,416 CONSEQUENCES AND 1 OF THE MOST 1621 01:36:29,416 --> 01:36:32,853 COMMON CAUSE IN THE UNITED 1622 01:36:32,853 --> 01:36:39,026 STATES AND 14 MILLION AMERICANS 1623 01:36:39,026 --> 01:36:39,660 EACH YEAR IS MORTALITY FROM A 1624 01:36:39,660 --> 01:36:41,195 FALSE ALARM HAS INCREASED BY 1625 01:36:41,195 --> 01:36:47,368 41 PERCENT. 1626 01:36:47,368 --> 01:36:47,968 SO THE FOCUS OF THE PRESENTERS 1627 01:36:47,968 --> 01:36:49,103 IS ON THE THEORY OF AGING 1628 01:36:49,103 --> 01:36:55,809 RESEARCH OVER THE YEARS RESEARCH 1629 01:36:55,809 --> 01:36:56,377 AND UNDERSTANDING AND BETTER 1630 01:36:56,377 --> 01:36:57,011 PHYSIOLOGY AND LOSS OF FUNCTION 1631 01:36:57,011 --> 01:37:03,584 AND MOBILITY AND ALSO HOW TO 1632 01:37:03,584 --> 01:37:10,791 TREAT AND PRESENT THE ISSUE. 1633 01:37:10,791 --> 01:37:11,592 OVER THE YEARS TO BE VERY 1634 01:37:11,592 --> 01:37:14,328 PRODUCTIVE AND TO PUBLISH THE 1635 01:37:14,328 --> 01:37:21,936 ORIGINAL FINDINGS AND HAVE 1636 01:37:21,936 --> 01:37:29,009 CONDUCTED A NUMBER LIKE STRIDE 1637 01:37:29,009 --> 01:37:39,486 AND ENERGIZE AND THEN INTO A 1638 01:37:41,455 --> 01:37:46,627 LARGE RESEARCH PROGRAM AND THEN 1639 01:37:46,627 --> 01:37:51,532 TO ATTRACT YOUNG SCIENTIST 1640 01:37:51,532 --> 01:37:59,540 GENERATING A PIPELINE. 1641 01:37:59,540 --> 01:38:02,042 AND ALSO COLLABORATE WITH 1642 01:38:02,042 --> 01:38:10,184 PROGRAMS AND THESE INCLUDE THE 1643 01:38:10,184 --> 01:38:15,856 SYSTEMS RESEARCH NETWORK. 1644 01:38:15,856 --> 01:38:18,359 THEY HAVE THE RESEARCH EDUCATION 1645 01:38:18,359 --> 01:38:27,835 COMPONENT THE COMPONENT. 1646 01:38:27,835 --> 01:38:28,402 SO OVERALL IT BECOMES A VERY 1647 01:38:28,402 --> 01:38:34,441 SUPPORTIVE OF THE CONCEPT TO 1648 01:38:34,441 --> 01:38:42,983 BETTER TRANSLATE THE FINDINGS 1649 01:38:42,983 --> 01:38:52,626 AND TO IMPROVE THE CARE OF AND 1650 01:38:52,626 --> 01:38:53,193 WORKING HARD TO IMPROVE THE 1651 01:38:53,193 --> 01:38:53,761 RESEARCH FINDINGS FROM THIS 1652 01:38:53,761 --> 01:38:55,963 PROGRAM. 1653 01:38:55,963 --> 01:38:56,563 ALSO UNANIMOUS RECOMMENDATION 1654 01:38:56,563 --> 01:39:03,771 FOR INCREASE THE NUMBER AND ALSO 1655 01:39:03,771 --> 01:39:06,774 TO INCREASE THE ANNUAL BUDGET. 1656 01:39:06,774 --> 01:39:14,548 WE UNDERSTAND THE MOVING FORWARD 1657 01:39:14,548 --> 01:39:17,818 IN THIS IS WITH THE BUDGET IS 1658 01:39:17,818 --> 01:39:28,262 REALIZED FROM THE PROGRAM. 1659 01:39:30,431 --> 01:39:30,731 AND I THINK YOU. 1660 01:39:30,731 --> 01:39:31,532 WE WILL NOW MOVE TO THE LAST SET 1661 01:39:31,532 --> 01:39:36,770 OF CONCEPTS INVESTIGATED 1662 01:39:36,770 --> 01:39:37,237 MITOCHONDRIAL NUCLEAR 1663 01:39:37,237 --> 01:39:44,078 COMMUNICATION AND BRAIN AGING. 1664 01:39:44,078 --> 01:39:45,112 PLEASE SUMMARIZE THE CONCEPT AND 1665 01:39:45,112 --> 01:39:50,150 COMMENTS. 1666 01:39:50,150 --> 01:39:52,720 >> WITH THE MITOCHONDRIA 1667 01:39:52,720 --> 01:39:59,526 FUNCTION. 1668 01:39:59,526 --> 01:40:07,768 AS THE CREATOR AND THEN TO 1669 01:40:07,768 --> 01:40:08,635 COMPLETE A DIVERSE SET OF 1670 01:40:08,635 --> 01:40:19,179 BIOLOGIC FUNCTIONS AND ALL THAT 1671 01:40:21,115 --> 01:40:31,558 GENOMIC DNA AND ALSO SEARCHES 1672 01:40:41,602 --> 01:40:42,169 THROUGH OTHER PROTEINS AND ALSO 1673 01:40:42,169 --> 01:40:42,703 REQUIRES OTHER PROTEINS TO 1674 01:40:42,703 --> 01:40:43,170 CODIFY THE DNA SO THAT 1675 01:40:43,170 --> 01:40:43,704 COMMUNICATION BETWEEN THE 1676 01:40:43,704 --> 01:40:48,142 MITOCHONDRIA AND THE NUCLEUS IS 1677 01:40:48,142 --> 01:40:48,776 MITOCHONDRIAL FUNCTION AND ALSO 1678 01:40:48,776 --> 01:40:49,676 THE PROCESS BOTH PHYSIOLOGICAL 1679 01:40:49,676 --> 01:40:52,646 PREVENTION AND IN SOME CASE AS A 1680 01:40:52,646 --> 01:40:59,153 DISEASE. 1681 01:40:59,153 --> 01:41:07,294 SO THEN TO BE IDENTIFIED LEADING 1682 01:41:07,294 --> 01:41:09,730 TO SPECIES AND OTHER HEADLINES 1683 01:41:09,730 --> 01:41:15,402 AND TO BE METABOLIZED TO 1684 01:41:15,402 --> 01:41:17,938 PROFOUNDLY IMPACT THE 1685 01:41:17,938 --> 01:41:22,209 MODIFICATION OF PROTEINS AND 1686 01:41:22,209 --> 01:41:26,647 RESEARCHERS ARE BEGINNING TO 1687 01:41:26,647 --> 01:41:30,250 EXPLORE AND THE GENE REGULATION 1688 01:41:30,250 --> 01:41:40,694 AND EXPRESSION AND THEN TO 1689 01:41:45,566 --> 01:41:46,133 CONSIDER AS A METABOLIC TRANSFER 1690 01:41:46,133 --> 01:41:56,310 OF AGING. 1691 01:41:56,877 --> 01:41:57,377 SO IT IS THAT COMMUNICATION 1692 01:41:57,377 --> 01:42:03,016 LETTING THAT PLAY A KEY ROLE. 1693 01:42:03,016 --> 01:42:07,087 SO WITH THE COMMUNICATION IS THE 1694 01:42:07,087 --> 01:42:13,727 COMPLEXITY THAT IS STARTED. 1695 01:42:13,727 --> 01:42:18,165 IT IS THE DYNAMIC OF MANY 1696 01:42:18,165 --> 01:42:19,967 DIFFERENT STAGES AND THE NUMBER 1697 01:42:19,967 --> 01:42:30,410 OF CHALLENGES SO THEN THIS 1698 01:42:33,380 --> 01:42:37,951 PROPOSAL TO HELP STIMULATE ALL 1699 01:42:37,951 --> 01:42:48,462 THOSE SPECIFICALLY AND THEN TO 1700 01:42:49,863 --> 01:43:00,340 FURTHER STUDY THE COMMUNICATION 1701 01:43:02,109 --> 01:43:04,611 AND THEN TO EXPLORE AT ONCE AND 1702 01:43:04,611 --> 01:43:07,781 EXTEND WITH THE CELLULAR 1703 01:43:07,781 --> 01:43:08,949 FUNCTION. 1704 01:43:08,949 --> 01:43:19,459 AND THE PROPOSAL AND WITH THE 1705 01:43:26,333 --> 01:43:34,074 EXISTING CSR IS COMPLETE FROM 1706 01:43:34,074 --> 01:43:35,309 THE MITOCHONDRIA AND THE FUNDING 1707 01:43:35,309 --> 01:43:45,819 ALLOCATION THAT IS PROPOSED SO 1708 01:43:48,488 --> 01:43:48,989 IT IS HIGHLIGHTED TO THE NIA 1709 01:43:48,989 --> 01:43:50,724 GOALS AND ACTIVITIES. 1710 01:43:50,724 --> 01:43:55,829 SO WITH THE CONCEPT DISCUSSION A 1711 01:43:55,829 --> 01:44:02,769 WELL-DESIGNED SUPPORT. 1712 01:44:02,769 --> 01:44:09,943 >> THANK YOU. 1713 01:44:09,943 --> 01:44:10,510 THE NEXT IS THE BRAIN CELLS 1714 01:44:10,510 --> 01:44:18,585 SUBTYPES INDICATED OF AGING AND 1715 01:44:18,585 --> 01:44:19,186 DOCTOR BAKER PLEASE REVIEW THE 1716 01:44:19,186 --> 01:44:22,990 CONCEPT AND COMMENTS. 1717 01:44:22,990 --> 01:44:26,660 >> THE FOCUS OF THIS PARTICULAR 1718 01:44:26,660 --> 01:44:29,262 NOFO CONCEPT WAS UTILIZATION OF 1719 01:44:29,262 --> 01:44:33,834 NEW ELITE APOLOGY TO ADDRESS 1720 01:44:33,834 --> 01:44:34,401 QUESTIONS AND UNDERSTAND THE 1721 01:44:34,401 --> 01:44:36,503 ROLE OF SPECIFIC BRAIN CELLS 1722 01:44:36,503 --> 01:44:45,445 SUBTYPES MANY LARGE-SCALE 1723 01:44:45,445 --> 01:44:46,013 EFFORTS CURRENTLY FUNDED AND 1724 01:44:46,013 --> 01:44:47,748 IDENTIFYING THE PARTICULAR CELL 1725 01:44:47,748 --> 01:44:49,683 TYPES AND GENERATING HIGH 1726 01:44:49,683 --> 01:44:55,088 QUALITY SINGLE CELL AT THE 1727 01:44:55,088 --> 01:44:55,655 GENOMIC AND EPIGENETIC SITES 1728 01:44:55,655 --> 01:44:57,491 BOTH HUMAN TISSUE AND ORGANISMS 1729 01:44:57,491 --> 01:44:58,892 DURING NORMAL AGING AND 1730 01:44:58,892 --> 01:45:02,696 PROGRESSION FROM THE SUPPORTED 1731 01:45:02,696 --> 01:45:05,432 PROJECTS THAT HAVE UNCOVERED 1732 01:45:05,432 --> 01:45:07,434 DISEASES ACROSS ALL MAJOR CELL 1733 01:45:07,434 --> 01:45:13,707 TYPES TO IDENTIFY INCLUDING 1734 01:45:13,707 --> 01:45:20,414 NEURONS AND VASCULAR CELLS. 1735 01:45:20,414 --> 01:45:21,048 BUT IT IS NOT EXACTLY CLEAR HOW 1736 01:45:21,048 --> 01:45:21,615 THESE CHANGES CONTRIBUTE TO 1737 01:45:21,615 --> 01:45:25,318 DEFICITS OR BRAIN FUNCTIONS THE 1738 01:45:25,318 --> 01:45:25,952 GOAL IS TO DEVELOP NODULES -- -- 1739 01:45:25,952 --> 01:45:29,556 NOVEL STRATEGIES TO BE 1740 01:45:29,556 --> 01:45:31,958 IMPLICATED TO IMPLEMENT THE 1741 01:45:31,958 --> 01:45:33,460 TOOLS TO THE MECHANISTIC 1742 01:45:33,460 --> 01:45:39,699 HYPOTHESIS WITH THE 1743 01:45:39,699 --> 01:45:40,267 BREAKTHROUGHS OF MECHANISTIC 1744 01:45:40,267 --> 01:45:40,901 RESEARCH AND PRECLINICAL STUDIES 1745 01:45:40,901 --> 01:45:46,039 TO ACCOMPLISH THIS THE PLAN WAS 1746 01:45:46,039 --> 01:45:48,975 TO ACHIEVE 2 MAJOR OBJECTIVES TO 1747 01:45:48,975 --> 01:45:59,486 WITH THE SUBTYPES AND WITH THE 1748 01:46:01,521 --> 01:46:02,289 EPIGENETIC'S AND THE SUBTYPES 1749 01:46:02,289 --> 01:46:07,394 LIKELY TO HAVE A ROLE IN THOSE 1750 01:46:07,394 --> 01:46:10,430 TO VERIFY AND THOSE WOULD ALSO 1751 01:46:10,430 --> 01:46:16,503 BE SUPPORTED AND THEN TO ACHIEVE 1752 01:46:16,503 --> 01:46:19,206 WITH THAT TARGETING AND THE 1753 01:46:19,206 --> 01:46:24,111 BRAINS FROM ANIMAL MODELS. 1754 01:46:24,111 --> 01:46:30,617 THE SECOND IS TO HAVE THE 1755 01:46:30,617 --> 01:46:31,251 ENHANCER TOOLS WITH THE SUBTYPES 1756 01:46:31,251 --> 01:46:31,852 TO ADDRESS THE MECHANISTIC 1757 01:46:31,852 --> 01:46:34,488 HYPOTHESIS TO UNCOVER THE ROLE 1758 01:46:34,488 --> 01:46:42,028 OF DISEASE PROGRESSION AND THOSE 1759 01:46:42,028 --> 01:46:44,498 THAT ARE LOADED INTO THE AV 1760 01:46:44,498 --> 01:46:48,568 MODEL IT IS USEFUL FOR DIGESTING 1761 01:46:48,568 --> 01:46:52,005 THE FUNCTION AND REPRESSION 1762 01:46:52,005 --> 01:46:56,209 INCLUDING LIKE THE FLUORESCENT 1763 01:46:56,209 --> 01:47:00,847 PROTEINS TRANSCRIPTION FACTORS 1764 01:47:00,847 --> 01:47:11,091 AND OTHER ELEMENTS. 1765 01:47:11,091 --> 01:47:11,658 THIS IS A VERY RELEVANT VIEW 1766 01:47:11,658 --> 01:47:12,225 WITH A LOT OF OPPORTUNITY TO 1767 01:47:12,225 --> 01:47:12,759 BYPASS THE LIMITATIONS OF 1768 01:47:12,759 --> 01:47:18,565 GENETIC APPROACHES THE COMMITTEE 1769 01:47:18,565 --> 01:47:19,399 WAS HIGHLY SUPPORTIVE OF THE 1770 01:47:19,399 --> 01:47:29,776 OVERALL CONCEPT SPENT THE NEXT 1771 01:47:29,776 --> 01:47:32,345 CONCEPT IS THE DRUG DEVELOPMENT 1772 01:47:32,345 --> 01:47:42,489 PROGRAM. 1773 01:47:45,892 --> 01:47:46,960 PLEASE GO AHEAD. 1774 01:47:46,960 --> 01:47:54,201 >> THIS IS A RENEWAL OF YEAR 1 1775 01:47:54,201 --> 01:47:58,838 DATABASE PROGRAM FOR DRUG 1776 01:47:58,838 --> 01:47:59,139 DEVELOPMENT. 1777 01:47:59,139 --> 01:48:05,979 IT WAS ORIGINALLY LAUNCHED 2006 1778 01:48:05,979 --> 01:48:06,613 AND THE GOAL WAS TO INCREASE THE 1779 01:48:06,613 --> 01:48:10,483 NUMBER OF EMERGING CANDIDATES TO 1780 01:48:10,483 --> 01:48:11,818 INCREASE THE DIVERSITY OF 1781 01:48:11,818 --> 01:48:16,289 APPROACHES. 1782 01:48:16,289 --> 01:48:17,757 THIS PROGRAM FUNDS A BROADER 1783 01:48:17,757 --> 01:48:21,761 RANGE OF THE PIPELINE FROM EARLY 1784 01:48:21,761 --> 01:48:24,030 STAGES SUCH AS MEDICINAL 1785 01:48:24,030 --> 01:48:34,341 CHEMISTRY AND THERAPEUTIC AGENTS 1786 01:48:34,341 --> 01:48:34,874 WITH ABSORPTION AND OTHER 1787 01:48:34,874 --> 01:48:35,408 FEATURES AND EFFICACY AND 1788 01:48:35,408 --> 01:48:40,247 PRECLINICAL MODELS OF 1789 01:48:40,247 --> 01:48:41,281 FORMULATION. 1790 01:48:41,281 --> 01:48:46,186 CHEMICAL SYNTHESIS AT THE GMP 1791 01:48:46,186 --> 01:48:50,123 LEVEL REQUIRED FOR A CLINICAL 1792 01:48:50,123 --> 01:48:54,694 TRIAL SUCH AS LARGE ANIMAL 1793 01:48:54,694 --> 01:49:03,036 TOXICITY ALL THE WAY INTO PHASE 1794 01:49:03,036 --> 01:49:03,370 HUMAN TESTING. 1795 01:49:03,370 --> 01:49:03,970 CLINICAL MILESTONES ALONG THE 1796 01:49:03,970 --> 01:49:04,437 PATHWAY TO THERAPEUTIC 1797 01:49:04,437 --> 01:49:07,774 DEVELOPMENT. 1798 01:49:07,774 --> 01:49:08,808 TODAY IT IS GREAT TO HAVE 1799 01:49:08,808 --> 01:49:13,046 QUANTITATIVE DATA PER GO 45 YEAR 1800 01:49:13,046 --> 01:49:17,651 1 PROJECTS HAVE BEEN FUNDED AND 1801 01:49:17,651 --> 01:49:23,990 12 OF THESE HAVE RESULTED IN 1802 01:49:23,990 --> 01:49:24,624 CANDIDATE THERAPEUTICS MAKING IT 1803 01:49:24,624 --> 01:49:25,258 TO HUMAN TRIALS. 1804 01:49:25,258 --> 01:49:28,395 THAT IS AN OPPRESSIVE RATIO. 1805 01:49:28,395 --> 01:49:33,667 IF YOU REVIEW DRUG DEVELOPMENT 1806 01:49:33,667 --> 01:49:34,200 AND CMS DISEASES INCLUDING 1807 01:49:34,200 --> 01:49:34,801 ALZHEIMER'S YOU SEE A MASSIVE 1808 01:49:34,801 --> 01:49:40,707 DROP OFF RATE SO 12 OUT OF 45 IS 1809 01:49:40,707 --> 01:49:44,511 IMPRESSIVE SOME OF THESE MAKE IT 1810 01:49:44,511 --> 01:49:46,346 INTO PHASE 2 TRIALS. 1811 01:49:46,346 --> 01:49:50,984 ALSO A STRONG POINT A MILESTONE 1812 01:49:50,984 --> 01:49:56,289 DRIVEN PROGRAM AND THAT IS 1813 01:49:56,289 --> 01:49:56,890 EXECUTED FORTUNATELY TO OTHER 1814 01:49:56,890 --> 01:49:59,526 PROJECTS HAD TO BE TERMINATED 1815 01:49:59,526 --> 01:50:00,593 DUE TO NOT MAKING THE 1816 01:50:00,593 --> 01:50:02,362 MILESTONES. 1817 01:50:02,362 --> 01:50:06,266 THE RENEWAL OF THIS PROGRAM WILL 1818 01:50:06,266 --> 01:50:11,004 FUND A SIMILAR PIPELINE AND 1819 01:50:11,004 --> 01:50:14,774 EXPAND THE NUMBER OF CANDIDATES 1820 01:50:14,774 --> 01:50:15,175 AND THE DIVERSITY. 1821 01:50:15,175 --> 01:50:22,649 IT IS IMPORTANT BECAUSE OTHER 1822 01:50:22,649 --> 01:50:28,955 PROGRAMS ARE IDENTIFYING TARGETS 1823 01:50:28,955 --> 01:50:30,323 SO THIS WILL ENABLE THE 1824 01:50:30,323 --> 01:50:33,927 DEVELOPMENT OF AGENTS TO GO 1825 01:50:33,927 --> 01:50:34,894 AFTER THAT EMERGING LARGE NUMBER 1826 01:50:34,894 --> 01:50:45,372 OF TARGETS AND THEN TO SUPPORT 1827 01:50:45,372 --> 01:50:46,940 DEVELOPMENT WITH NEW TARGETS ARE 1828 01:50:46,940 --> 01:50:53,079 IDENTIFIED AND THEN TO ALSO 1829 01:50:53,079 --> 01:50:56,049 SERVE AS NEW BRAIN IMAGING AND 1830 01:50:56,049 --> 01:50:58,218 THE CAPABILITY TO DO 2 CRITICAL 1831 01:50:58,218 --> 01:50:59,652 THINGS TO ALLOW PRECISION AND 1832 01:50:59,652 --> 01:51:04,557 MEDICAL APPROACH AND WHAT THEIR 1833 01:51:04,557 --> 01:51:07,794 BEES MIGHT BE THE BEST AND ALSO 1834 01:51:07,794 --> 01:51:12,332 TO DOCUMENT TARGET ENGAGEMENT. 1835 01:51:12,332 --> 01:51:12,899 SO THIS PROGRAM WE THINK IS 1836 01:51:12,899 --> 01:51:16,469 HIGHLY SUCCESSFUL AND SHOULD BE 1837 01:51:16,469 --> 01:51:22,709 RENEWED. 1838 01:51:22,709 --> 01:51:23,042 >> THANK YOU. 1839 01:51:23,042 --> 01:51:23,610 WE WILL NOW MOVE TO THE NEXT 1840 01:51:23,610 --> 01:51:26,012 CONCEPT OF COGNITIVE DECLINE OF 1841 01:51:26,012 --> 01:51:28,515 INDIVIDUALS WITHIN THE AUTISM 1842 01:51:28,515 --> 01:51:36,589 SPECTRUM. 1843 01:51:36,589 --> 01:51:37,190 SO PLEASE PRESENT THE CONCEPT 1844 01:51:37,190 --> 01:51:46,366 AND THE COMMENTS. 1845 01:51:46,366 --> 01:51:50,236 >> THIS IS A NEW CONCEPT THAT 1846 01:51:50,236 --> 01:51:58,178 SEEKS TO ESTABLISH COHORTS WITH 1847 01:51:58,178 --> 01:51:58,812 AUTISM SPECTRUM DISORDER AND TO 1848 01:51:58,812 --> 01:52:03,650 COLLECT PROSPECTIVE DATA TO 1849 01:52:03,650 --> 01:52:08,721 UNDERSTAND THE PHYSIOLOGY IS 1850 01:52:08,721 --> 01:52:11,191 VERY COMPLEX DEVELOPMENTAL 1851 01:52:11,191 --> 01:52:14,227 DISORDER. 1852 01:52:14,227 --> 01:52:14,828 IF APPROVED THEN FOR THE FIRST 1853 01:52:14,828 --> 01:52:17,230 TIME IT WOULD ALLOW AN IA TO 1854 01:52:17,230 --> 01:52:21,000 LAUNCH SYSTEMATIC STUDIES AND 1855 01:52:21,000 --> 01:52:28,575 THEN TO DEVELOP MARKERS FOR THIS 1856 01:52:28,575 --> 01:52:29,008 IMPORTANT DISORDER. 1857 01:52:29,008 --> 01:52:32,378 SO IT IS QUITE COMMON AND IS 1858 01:52:32,378 --> 01:52:42,722 SIMULATED IN CHILDREN ACROSS 1859 01:52:42,722 --> 01:52:43,356 UNITED STATES AND IT SEEMS TO BE 1860 01:52:43,356 --> 01:52:43,990 HIGHER AND BLACKS AND HISPANICS 1861 01:52:43,990 --> 01:52:45,625 AND ASIAN AND PACIFIC ISLANDERS 1862 01:52:45,625 --> 01:52:49,863 IT IS A FACETED DISEASE WITH 1863 01:52:49,863 --> 01:52:58,004 SIGNIFICANT HETEROGENEITY AND 1864 01:52:58,004 --> 01:53:06,446 THERE'S EPIDEMIOLOGICAL STUDIES 1865 01:53:06,446 --> 01:53:07,013 AND THEN THEY HAVE INCREASED 1866 01:53:07,013 --> 01:53:10,216 RISK OF DEMENTIA AND ALSO TO 1867 01:53:10,216 --> 01:53:15,622 HAVE SOME COGNITIVE DEFICITS 1868 01:53:15,622 --> 01:53:21,261 WITH THE PROCESSING SPEED AND 1869 01:53:21,261 --> 01:53:27,267 STUDIES TO HAVE THAT FUNCTIONAL 1870 01:53:27,267 --> 01:53:34,507 CONNECTIVITY SO THERE IS SOME 1871 01:53:34,507 --> 01:53:40,313 EVIDENCE BUT IT IS PRELIMINARY 1872 01:53:40,313 --> 01:53:44,784 AND NEEDS TO BE CONFIRMED. 1873 01:53:44,784 --> 01:53:50,256 PEOPLE WITH ASD WITH THESE 1874 01:53:50,256 --> 01:53:53,426 PATHWAYS IN THEIR BRAINS AND 1875 01:53:53,426 --> 01:53:59,799 THERE COULD BE SOME MECHANISMS 1876 01:53:59,799 --> 01:54:02,368 SO OVERALL THERE IS VERY LIMITED 1877 01:54:02,368 --> 01:54:07,040 RESEARCH AND THE BIOGENETIC'S 1878 01:54:07,040 --> 01:54:10,343 WITH THE HETEROGENEITY AND THE 1879 01:54:10,343 --> 01:54:16,316 BIOMARKERS WE HAVE FOUND THIS IS 1880 01:54:16,316 --> 01:54:23,122 A TIMELY PROPOSAL TO GENERATE 1881 01:54:23,122 --> 01:54:33,633 NEW INFORMATION THAT IS QUITE 1882 01:54:33,933 --> 01:54:37,971 COMMON AND ALSO WITH DEMENTIA 1883 01:54:37,971 --> 01:54:40,640 AND OVERALL IT IS HIGHLY 1884 01:54:40,640 --> 01:54:48,448 SUPPORTIVE AND IT'S A VERY 1885 01:54:48,448 --> 01:54:48,815 TIMELY CONCEPT. 1886 01:54:48,815 --> 01:54:59,258 THANK YOU FOR PROVING IT. 1887 01:54:59,859 --> 01:55:00,293 >> AND THE FINAL CONCEPT 1888 01:55:00,293 --> 01:55:00,893 DECIPHERING THE IMPACT OF RNA 1889 01:55:00,893 --> 01:55:01,527 MODIFICATION ON BRAIN AGING AND 1890 01:55:01,527 --> 01:55:01,861 A/D / ADR D. 1891 01:55:01,861 --> 01:55:06,165 PLEASE REVIEW THE CONCEPT AND 1892 01:55:06,165 --> 01:55:09,002 COMMENTS. 1893 01:55:09,002 --> 01:55:13,606 >> THE CHEMICAL MODIFICATION OF 1894 01:55:13,606 --> 01:55:15,742 RNA HAS BEEN DOCUMENTED OVER THE 1895 01:55:15,742 --> 01:55:20,146 YEARS WITH THAT GENOMIC 1896 01:55:20,146 --> 01:55:30,623 TECHNOLOGY SO SO FAR TO HAVE 1897 01:55:31,557 --> 01:55:32,091 THAT DISTINCT MODIFICATION HAS 1898 01:55:32,091 --> 01:55:40,667 BEEN IDENTIFIED AND WITH THE 1899 01:55:40,667 --> 01:55:43,569 HOMEOSTASIS OF THESE COURSES 1900 01:55:43,569 --> 01:55:45,104 THERE IS A BRILLIANT 1901 01:55:45,104 --> 01:55:53,012 RECOMMENDATION THAT HAS DIRECT 1902 01:55:53,012 --> 01:55:55,682 EFFECTS OF PHYSIOLOGICAL 1903 01:55:55,682 --> 01:55:59,686 PROCESSES AND IT DOES INDICATE 1904 01:55:59,686 --> 01:56:08,961 THAT IT IS A DYSFUNCTION AND IT 1905 01:56:08,961 --> 01:56:15,168 IS IMPLICATING WITH THE 1906 01:56:15,168 --> 01:56:21,507 DEGENERATING DISORDER HOWEVER 1907 01:56:21,507 --> 01:56:30,917 THE DIVERSITY OF THIS IS 1908 01:56:30,917 --> 01:56:37,223 EXPLORED. 1909 01:56:37,223 --> 01:56:38,758 SO FAR DEVOTED TO THE 1910 01:56:38,758 --> 01:56:42,695 MODIFICATIONS SO IT IS THE 1911 01:56:42,695 --> 01:56:44,063 SIGNIFICANCE OF THE 1912 01:56:44,063 --> 01:56:48,267 MODIFICATIONS IS JUST BEGINNING 1913 01:56:48,267 --> 01:56:55,575 TO BE APPROACHED AND WITH THIS 1914 01:56:55,575 --> 01:56:58,745 MODIFICATION THAT IS EMERGING 1915 01:56:58,745 --> 01:57:07,286 WITH THE BIOMARKERS AND IN THE 1916 01:57:07,286 --> 01:57:08,654 FUNCTIONAL ROLES IN THE 1917 01:57:08,654 --> 01:57:17,063 RELATIONSHIP WITH THE PROCESSOR 1918 01:57:17,063 --> 01:57:22,702 SO I AM OPTIMISTIC BUT WITH THE 1919 01:57:22,702 --> 01:57:27,940 REGULATION AND THROUGH THAT 1920 01:57:27,940 --> 01:57:37,250 PROCESS AND THEN TO FINE-TUNE 1921 01:57:37,250 --> 01:57:37,850 THE REGULATION AND UNDERSTAND 1922 01:57:37,850 --> 01:57:38,451 THE DISEASE AND TO INFORM NEW 1923 01:57:38,451 --> 01:57:44,991 STRATEGIES. 1924 01:57:44,991 --> 01:57:45,591 SO WITH THE BACKGROUND AND THE 1925 01:57:45,591 --> 01:57:47,593 PROPOSAL IS TO STIMULATE 1926 01:57:47,593 --> 01:57:58,104 RESEARCH WITH THE MODIFICATION 1927 01:57:58,805 --> 01:58:03,342 AND THE RNA MODIFICATION WITH 1928 01:58:03,342 --> 01:58:09,482 POTENTIAL TARGETS. 1929 01:58:09,482 --> 01:58:11,984 SO THERE ARE SEVERAL AREAS OF 1930 01:58:11,984 --> 01:58:19,225 INTEREST TO IDENTIFY THIS 1931 01:58:19,225 --> 01:58:25,498 PROGRAM AND THEN IT IS SHARED 1932 01:58:25,498 --> 01:58:35,908 AND THEY AN IA SUPPORT. 1933 01:58:38,477 --> 01:58:48,921 SO THAT MECHANISM AND THIS IS 1934 01:58:50,022 --> 01:58:53,659 CLEARLY HIGHLY RELEVANT TO THE 1935 01:58:53,659 --> 01:58:57,697 GOALS AND OBJECTIVES SO TO 1936 01:58:57,697 --> 01:59:02,568 DISCUSS WITH THE COUNCIL HOW DO 1937 01:59:02,568 --> 01:59:12,778 WE SUPPORT. 1938 01:59:13,145 --> 01:59:13,346 THANK YOU. 1939 01:59:13,346 --> 01:59:13,880 >> AGAIN THANK YOU TO THE 1940 01:59:13,880 --> 01:59:14,513 COUNCIL FOR THE VERY THOUGHTFUL 1941 01:59:14,513 --> 01:59:15,281 REVIEWS AND COMMENTS. 1942 01:59:15,281 --> 01:59:20,720 AT THIS POINT WE WILL VOTE ON 1943 01:59:20,720 --> 01:59:26,926 BLOCK FOR ALL OF THE CONCEPTS. 1944 01:59:26,926 --> 01:59:27,560 IF WE CAN SEE A SHOW OF HANDS OR 1945 01:59:27,560 --> 01:59:29,428 COMMENTS FOR ALL OF THOSE IN 1946 01:59:29,428 --> 01:59:31,998 FAVOR? 1947 01:59:31,998 --> 01:59:36,002 CAN WE SEE A SHOW OF HANDS? 1948 01:59:36,002 --> 01:59:42,675 ALL OF THOSE WHO DO NOT APPROVE? 1949 01:59:42,675 --> 01:59:47,413 IT APPEARS THERE IS ENTHUSIASM 1950 01:59:47,413 --> 01:59:47,914 FOR THE CONCEPTS TO MOVE 1951 01:59:47,914 --> 01:59:48,147 FORWARD. 1952 01:59:48,147 --> 01:59:51,317 AT THIS POINT I WILL SEND IT 1953 01:59:51,317 --> 01:59:52,585 BACK. 1954 01:59:52,585 --> 01:59:55,087 >> THANK YOU. 1955 01:59:55,087 --> 02:00:02,528 THANK YOU FOR SHARING THE WORK 1956 02:00:02,528 --> 02:00:03,029 YOU HAVE DONE AND TO ALL 1957 02:00:03,029 --> 02:00:03,529 COUNCILMEMBERS FOR THEIR 1958 02:00:03,529 --> 02:00:05,464 CRITIQUES AND CONCEPTS AND 1959 02:00:05,464 --> 02:00:08,334 DISCUSSION. 1960 02:00:08,334 --> 02:00:14,340 AT THIS POINT ON THE AGENDA WILL 1961 02:00:14,340 --> 02:00:14,941 HAVE 2 SPEAKERS BUT BEFORE WE 1962 02:00:14,941 --> 02:00:18,778 HAVE THAT WE WILL TAKE A QUICK 5 1963 02:00:18,778 --> 02:00:24,417 OR 10 MINUTE BREAK. 1964 02:00:24,417 --> 02:00:25,451 WE ARE RUNNING A LITTLE BIT LATE 1965 02:00:25,451 --> 02:00:29,322 TODAY. 1966 02:00:29,322 --> 02:00:31,891 SO JUST BREAK AND TELL 1967 02:00:31,891 --> 02:00:36,295 12:10 P.M. 1968 02:00:36,295 --> 02:00:36,929 THAT IS EASTERN TIME AND THEN WE 1969 02:00:36,929 --> 02:00:37,563 WILL BE BACK TO HEAR FROM THE 2 1970 02:00:37,563 --> 02:00:39,165 SPEAKERS. 1971 02:00:39,165 --> 02:00:42,735 PLEASE STAY ONLINE AND JUST 1972 02:00:42,735 --> 02:00:44,504 YOURSELF TO COME BACK AT 12:10 P.M. 1973 02:01:59,302 --> 02:02:00,303 >> THANK YOU FOR THE 1974 02:02:00,303 --> 02:02:04,307 INTRODUCTION. 1975 02:02:04,307 --> 02:02:05,441 BRING UP THE SIDES. 1976 02:02:05,441 --> 02:02:15,618 THANK YOU. 1977 02:02:17,687 --> 02:02:18,254 WE WILL GIVE YOU AN OVERVIEW OF 1978 02:02:18,254 --> 02:02:23,560 THE MISSION AND VISION AND WITH 1979 02:02:23,560 --> 02:02:24,994 THE PARTNERSHIPS IS THE 1980 02:02:24,994 --> 02:02:27,230 INVESTIGATION THE CONDITIONS 1981 02:02:27,230 --> 02:02:30,400 ACROSS THE LIFESPAN KNOWN AS THE 1982 02:02:30,400 --> 02:02:33,236 INCLUDE PROGRAM. 1983 02:02:33,236 --> 02:02:34,237 PART OF MY INTRAMURAL RESEARCH 1984 02:02:34,237 --> 02:02:38,675 LABORATORIES EFFORTS WITH DOWN 1985 02:02:38,675 --> 02:02:39,542 SYNDROME AT THE PRENATAL AND 1986 02:02:39,542 --> 02:02:41,377 LIFESPAN. 1987 02:02:41,377 --> 02:02:46,015 AND TO TALK ABOUT WHAT IS A VERY 1988 02:02:46,015 --> 02:02:47,517 INTERESTING AREA FOR FURTHER 1989 02:02:47,517 --> 02:02:51,688 INVESTIGATION THAT IS IN THE 1990 02:02:51,688 --> 02:02:52,255 NEONATOLOGY AND GERONTOLOGY 1991 02:02:52,255 --> 02:02:55,425 CONNECTION AND ALSO THE AREA 1992 02:02:55,425 --> 02:02:56,025 THAT WE COULD COLLABORATE MORE 1993 02:02:56,025 --> 02:02:59,495 IN THE FUTURE IS THE LIFESPAN OF 1994 02:02:59,495 --> 02:03:03,299 REPRODUCTIVE BIOLOGY IS IN WOMEN 1995 02:03:03,299 --> 02:03:06,102 FROM MENARCHE TO MENOPAUSE. 1996 02:03:06,102 --> 02:03:10,406 'S WE ARE MORE THAN JUST 1997 02:03:10,406 --> 02:03:17,013 PARTNERS BUT JOINED AT THE HIP. 1998 02:03:17,013 --> 02:03:23,553 THIS IS THE DAY THAT AND I CHD 1999 02:03:23,553 --> 02:03:31,928 ENCOMPASSED AGING'S THIS 2000 02:03:31,928 --> 02:03:32,462 LEGISLATION WILL ENCOURAGE 2001 02:03:32,462 --> 02:03:33,696 IMAGINATIVE RESEARCH INTO THE 2002 02:03:33,696 --> 02:03:34,230 COMPLEX PROCESSES OF HUMAN 2003 02:03:34,230 --> 02:03:42,171 DEVELOPMENT FROM CONCEPTION AND 2004 02:03:42,171 --> 02:03:44,440 THEN THROUGH THE VOICE OF HIS 2005 02:03:44,440 --> 02:03:54,017 SISTER EUNICE KENNEDY SHRIVER 2006 02:03:54,017 --> 02:03:55,051 AND THEN AGING WAS SPLIT OFF TO 2007 02:03:55,051 --> 02:04:04,794 TAKE THE OPPORTUNITY. 2008 02:04:04,794 --> 02:04:11,200 SO WHEN I CAME ON LATE 2016 WE 2009 02:04:11,200 --> 02:04:13,636 DID NOT HAVE A STRATEGIC PLAN IN 2010 02:04:13,636 --> 02:04:17,907 PLACE ALSO A VERY WORDY MISSION 2011 02:04:17,907 --> 02:04:25,214 STATEMENT IT WAS LIKE JAY LENO 2012 02:04:25,214 --> 02:04:25,782 QUESTIONING OF PEOPLE ON THE 2013 02:04:25,782 --> 02:04:26,649 STREET DO THEY KNOW OUR MISSION 2014 02:04:26,649 --> 02:04:27,717 AND NOBODY INCLUDING ME COULD AT 2015 02:04:27,717 --> 02:04:31,020 THE TIME. 2016 02:04:31,020 --> 02:04:41,531 SO WE FOCUS THAT WITH THAT TO 2017 02:04:42,398 --> 02:04:42,932 ENHANCE THE LIVES OF CHILDREN 2018 02:04:42,932 --> 02:04:44,901 AND ADOLESCENTS TO OPTIMIZE FOR 2019 02:04:44,901 --> 02:04:51,607 ALL. 2020 02:04:51,607 --> 02:04:57,847 AND THAT REHABILITATION RESEARCH 2021 02:04:57,847 --> 02:05:00,416 AND PEOPLE ARE SOMEWHAT 2022 02:05:00,416 --> 02:05:04,354 SURPRISED REHABILITATION FROM 2023 02:05:04,354 --> 02:05:08,091 STROKE IN ADULTS AND WE 2024 02:05:08,091 --> 02:05:17,834 DEFINITELY OVERLAP SO NOT HAVING 2025 02:05:17,834 --> 02:05:26,075 A STRATEGIC PLAN THAT TAKES 2026 02:05:26,075 --> 02:05:27,010 ABOUT 2 YEARS TO COME UP WITH A 2027 02:05:27,010 --> 02:05:28,478 STRATEGIC PLAN IN 2020 STARTING 2028 02:05:28,478 --> 02:05:32,048 WITH 270 AND TAKING IT DOWN TO 2029 02:05:32,048 --> 02:05:34,650 5. 2030 02:05:34,650 --> 02:05:38,221 SO TO UNDERSTAND THE MOLECULAR 2031 02:05:38,221 --> 02:05:42,225 DEVELOPMENT PROMOTING 2032 02:05:42,225 --> 02:05:42,859 REPRODUCTIVE HEALTH AND SETTING 2033 02:05:42,859 --> 02:05:53,302 THE FOUNDATION FOR HELPING 2034 02:05:57,640 --> 02:05:58,207 WELLNESS AND IMPROVING CHILD AND 2035 02:05:58,207 --> 02:05:58,741 ADOLESCENT HEALTH AND THE 2036 02:05:58,741 --> 02:05:59,375 TRANSITION TO ADULTHOOD WHICH IS 2037 02:05:59,375 --> 02:06:00,009 A MAJOR GAP AREA ACROSS NIH AND 2038 02:06:00,009 --> 02:06:00,510 THEN ADVANCING SAFE AND 2039 02:06:00,510 --> 02:06:01,644 EFFECTIVE THERAPEUTICS FOR 2040 02:06:01,644 --> 02:06:06,082 PREGNANT AND LACTATING WOMEN AND 2041 02:06:06,082 --> 02:06:07,984 CHILDREN WITH INTELLECTUAL 2042 02:06:07,984 --> 02:06:13,890 DISABILITIES. 2043 02:06:13,890 --> 02:06:14,524 THEY HEAR THE NAME CHILD HEALTH 2044 02:06:14,524 --> 02:06:15,425 AND THAT INCLUDES MEMBERS OF 2045 02:06:15,425 --> 02:06:19,228 CONGRESS, THEY THINK WE FIND ALL 2046 02:06:19,228 --> 02:06:19,862 OF CHILD HEALTH RESEARCH ACROSS 2047 02:06:19,862 --> 02:06:20,029 NIH. 2048 02:06:20,029 --> 02:06:27,870 THAT IS NOT TRUE WHEN YOU LOOK 2049 02:06:27,870 --> 02:06:28,504 ACROSS AND 8 H IT IS 18 PERCENT 2050 02:06:28,504 --> 02:06:29,105 OF CHILD HEALTH RESEARCH WHICH 2051 02:06:29,105 --> 02:06:33,176 MEANS A LOT OF OTHER INSTITUTES 2052 02:06:33,176 --> 02:06:33,776 HAVE BEEN FUNDED CHILD HEALTH 2053 02:06:33,776 --> 02:06:38,681 RESEARCH NOT AN IA BUT OTHERS. 2054 02:06:38,681 --> 02:06:39,282 WITHIN OUR OWN PORTFOLIO IT IS 2055 02:06:39,282 --> 02:06:42,585 HALF PEDIATRICS, 1 THIRD 2056 02:06:42,585 --> 02:06:45,088 REPRODUCTIVE HEALTH WHICH 2057 02:06:45,088 --> 02:06:47,824 INCLUDES EVERYTHING FOR 2058 02:06:47,824 --> 02:06:52,395 DEVELOPMENT TO PRE- CONCEPTUAL 2059 02:06:52,395 --> 02:06:53,963 HEALTH, CONTRACEPTION, PREGNANCY 2060 02:06:53,963 --> 02:06:57,667 AND POSTPARTUM HEALTH. 2061 02:06:57,667 --> 02:06:59,168 AND THEN 18 PERCENT IS A STRONG 2062 02:06:59,168 --> 02:07:02,338 COMMITMENT AND THEN THE NATIONAL 2063 02:07:02,338 --> 02:07:03,139 CENTER FOR MEDICAL 2064 02:07:03,139 --> 02:07:06,542 REHABILITATION RESEARCH. 2065 02:07:06,542 --> 02:07:17,186 OF COURSE NAME FOR PRESIDENT 2066 02:07:17,186 --> 02:07:17,687 KENNEDY'S SISTER AND A MAJOR 2067 02:07:17,687 --> 02:07:17,887 FORCE. 2068 02:07:17,887 --> 02:07:18,521 IN FACT THE BIOGRAPHY MAKES THE 2069 02:07:18,521 --> 02:07:19,755 CASE THAT SHE WOULD HAVE BEEN 2070 02:07:19,755 --> 02:07:21,157 PRESIDENT IF THE ARROW WAS 2071 02:07:21,157 --> 02:07:27,864 DIFFERENT. 2072 02:07:27,864 --> 02:07:28,464 A LITTLE UPDATE ON INCLUDE WE 2073 02:07:28,464 --> 02:07:32,135 ARE STRONG PARTNERS WITH AN IA 2074 02:07:32,135 --> 02:07:38,674 INCLUDING PROGRAM LAUNCHED IN 2075 02:07:38,674 --> 02:07:42,078 2018 TO INCREASE THE RESEARCH 2076 02:07:42,078 --> 02:07:42,678 PORTFOLIO IN DOWN SYNDROME TO 2077 02:07:42,678 --> 02:07:43,279 ADDRESS THE HEALTH AND QUALITY 2078 02:07:43,279 --> 02:07:46,382 OF LIFE FOR PEOPLE WHO HAVE DOWN 2079 02:07:46,382 --> 02:07:54,023 SYNDROME. 2080 02:07:54,023 --> 02:07:54,657 THE CONDITIONS WE ARE FOCUSED ON 2081 02:07:54,657 --> 02:07:55,558 IS A COMBINATION OF CONDITIONS 2082 02:07:55,558 --> 02:07:58,261 MORE PREVALENT IN PEOPLE WITH 2083 02:07:58,261 --> 02:08:00,563 DOWN SYNDROME SUCH AS 2084 02:08:00,563 --> 02:08:03,499 ALZHEIMER'S, AUTISM, HEART 2085 02:08:03,499 --> 02:08:04,567 DISEASE, ET CETERA BUT 2086 02:08:04,567 --> 02:08:07,470 SIMULTANEOUSLY LOOKING AT HOW 2087 02:08:07,470 --> 02:08:10,339 PEOPLE WITH DOWN SYNDROME ARE 2088 02:08:10,339 --> 02:08:16,712 PROTECTED FROM TUMORS. 2089 02:08:16,712 --> 02:08:19,215 SO WE COULD LEARN MORE THAT 2090 02:08:19,215 --> 02:08:22,685 APPLIES THE KNOWLEDGE OF THE 2091 02:08:22,685 --> 02:08:23,119 GENERAL POPULATION. 2092 02:08:23,119 --> 02:08:29,492 ALSO INCREASING THE WORKFORCE BY 2093 02:08:29,492 --> 02:08:30,059 A TRAINING MORE PEOPLE TO DO 2094 02:08:30,059 --> 02:08:35,097 SCIENCE AND ALSO HAVE STRONG 2095 02:08:35,097 --> 02:08:40,670 ENGAGEMENT SOME ADVOCATES AND 2096 02:08:40,670 --> 02:08:46,842 THOSE FROM DIVERSE BACKGROUNDS. 2097 02:08:46,842 --> 02:08:49,412 SO I REMEMBER VERY CLEARLY 2098 02:08:49,412 --> 02:08:53,616 BECAUSE WE GOT THIS UNEXPECTED 2099 02:08:53,616 --> 02:08:55,885 MESSAGE FROM CONGRESS IN 2017 2100 02:08:55,885 --> 02:09:06,429 THAT THERE WAS AN ADVOCATE MR.'S 2101 02:09:10,199 --> 02:09:10,766 STEVENS WHO SOLICITED A STANDING 2102 02:09:10,766 --> 02:09:11,534 OVATION FROM THE APPROPRIATIONS 2103 02:09:11,534 --> 02:09:12,168 COMMITTEE IN THE HOUSE AND MONEY 2104 02:09:12,168 --> 02:09:18,708 STARTED TO COME IN TO THE NIH 2105 02:09:18,708 --> 02:09:19,308 SPECIFICALLY FOR DOWN SYNDROME 2106 02:09:19,308 --> 02:09:19,575 RESEARCH. 2107 02:09:19,575 --> 02:09:30,119 IT WAS EASTER WEEKEND 2017 WHERE 2108 02:09:36,259 --> 02:09:36,826 ALL STAFF WORK TOGETHER TO HAVE 2109 02:09:36,826 --> 02:09:37,293 3 PROGRAM COMPONENTS. 2110 02:09:37,293 --> 02:09:37,893 THE FIRST IS BASIC SCIENCE TO 2111 02:09:37,893 --> 02:09:38,494 CONDUCT HIGH RISK HIGH REWARD 2112 02:09:38,494 --> 02:09:39,128 BASIC SCIENCE AND STUDIES THAT 2113 02:09:39,128 --> 02:09:41,864 CENTER ON THE EFFECTS OF 2114 02:09:41,864 --> 02:09:46,736 CHROMOSOME 21. 2115 02:09:46,736 --> 02:09:47,303 THE SECOND COMPONENT WAS TO 2116 02:09:47,303 --> 02:09:48,271 ASSEMBLE LARGER STUDY 2117 02:09:48,271 --> 02:09:51,540 POPULATIONS TO UNDERSTAND WHAT 2118 02:09:51,540 --> 02:09:56,912 IS GOING ON IN UTERO LIFE TO 2119 02:09:56,912 --> 02:10:00,249 ADULT LIFE. 2120 02:10:00,249 --> 02:10:02,752 THE THIRD THING WAS TO BE MORE 2121 02:10:02,752 --> 02:10:06,455 INCLUSIVE BECAUSE IT WAS MEANT 2122 02:10:06,455 --> 02:10:07,657 TO EMPHASIZE INCLUSION OF 2123 02:10:07,657 --> 02:10:15,765 INDIVIDUALS WITH DOWN SYNDROME 2124 02:10:15,765 --> 02:10:16,399 AND EXISTING AND FUTURE CLINICAL 2125 02:10:16,399 --> 02:10:17,033 TRIALS SO PREVIOUSLY THEY WERE 2126 02:10:17,033 --> 02:10:17,633 EXCLUDED BECAUSE THEY HAD DOWN 2127 02:10:17,633 --> 02:10:22,238 SYNDROME. 2128 02:10:22,238 --> 02:10:22,872 IN THE LAST 4 OR 5 FISCAL YEARS 2129 02:10:22,872 --> 02:10:31,547 NIH HAS INVESTED $258 MILLION IN 2130 02:10:31,547 --> 02:10:32,181 PROJECTS FOR INCLUDE AND IT HAS 2131 02:10:32,181 --> 02:10:37,420 TRANSFORMED THE FIELD. 2132 02:10:37,420 --> 02:10:37,853 WHAT ARE SOME OF THE 2133 02:10:37,853 --> 02:10:42,958 ACHIEVEMENTS SO FAR? 2134 02:10:42,958 --> 02:10:44,460 THERE HAS BEEN AN INTENTIONAL 2135 02:10:44,460 --> 02:10:52,168 INVESTIGATION AS A RESULT OF 2136 02:10:52,168 --> 02:10:52,768 COVID 19 WITH RESULTS OF DOWN 2137 02:10:52,768 --> 02:10:53,402 SYNDROME AND THEY WERE AT HIGHER 2138 02:10:53,402 --> 02:10:53,903 RISK THAN THOSE WITHOUT. 2139 02:10:53,903 --> 02:11:00,409 STUDYING THE CAUSES OF CHILDREN 2140 02:11:00,409 --> 02:11:04,814 AND LEUKEMIA THAT IS MORE COMMON 2141 02:11:04,814 --> 02:11:05,348 MORE THAN A SOLID TUMOR OF 2142 02:11:05,348 --> 02:11:14,857 BREAST CANCER OR COLON CANCER 2143 02:11:14,857 --> 02:11:15,458 ALSO NEW COGNITIVE MEASURE IN 2144 02:11:15,458 --> 02:11:16,092 THE NIH TOOLBOX DIRECTED TOWARD 2145 02:11:16,092 --> 02:11:18,194 CHILDREN WITH DOWN SYNDROME AND 2146 02:11:18,194 --> 02:11:24,900 THE EFFORTS AND THEN 1 STUDY IS 2147 02:11:24,900 --> 02:11:32,675 DETERMINED IF IT IS AS RELIABLE 2148 02:11:32,675 --> 02:11:33,242 AS A HOSPITAL SLEEP A STUDY. 2149 02:11:33,242 --> 02:11:34,944 SLEEP APNEA IS A MAJOR PROBLEM 2150 02:11:34,944 --> 02:11:42,451 AND THEN TO ASSEMBLE A COHORT OF 2151 02:11:42,451 --> 02:11:43,586 ADULTS TO IDENTIFY BIOMARKERS OF 2152 02:11:43,586 --> 02:11:46,021 NEURODEGENERATION AND RESILIENCE 2153 02:11:46,021 --> 02:11:56,565 FACTOR FOR ALZHEIMER'S DISEASE. 2154 02:11:57,400 --> 02:11:57,967 SO I WILL GO BRIEFLY THROUGH THE 2155 02:11:57,967 --> 02:11:58,601 SLIDES BECAUSE I'M SURE YOU ARE 2156 02:11:58,601 --> 02:11:59,168 FAMILIAR WITH THE BIOMARKER 2157 02:11:59,168 --> 02:12:04,707 CONSORTIUM WHICH IS THE ABCD AS 2158 02:12:04,707 --> 02:12:05,341 PROJECT 92 INVESTIGATORS ACROSS 2159 02:12:05,341 --> 02:12:14,150 19 INSTITUTIONS. 2160 02:12:14,150 --> 02:12:14,784 THE BASIC IDEA IS THE BIOLOGICAL 2161 02:12:14,784 --> 02:12:15,384 CHANGES UNDERLYING ALZHEIMER'S 2162 02:12:15,384 --> 02:12:15,951 DISEASE IN PEOPLE WITH DOWN 2163 02:12:15,951 --> 02:12:17,653 SYNDROME AND DEVELOP CLINICAL 2164 02:12:17,653 --> 02:12:22,391 BIOMARKERS AS WELL AS THE NON- 2165 02:12:22,391 --> 02:12:24,827 DOWN SYNDROME POPULATION THERE 2166 02:12:24,827 --> 02:12:29,965 IS A LONGITUDINAL COHORTS THAT 2167 02:12:29,965 --> 02:12:31,801 HAS UP TO 600 ADULTS WITH DOWN 2168 02:12:31,801 --> 02:12:34,303 SYNDROME. 2169 02:12:34,303 --> 02:12:36,439 AGAIN THIS IS FULFILLING SOME OF 2170 02:12:36,439 --> 02:12:41,777 THE COMPONENTS OF THE INCLUDE 2171 02:12:41,777 --> 02:12:44,079 PROJECT'S. 2172 02:12:44,079 --> 02:12:47,516 ANOTHER STUDY IS AMYLOID BURDEN 2173 02:12:47,516 --> 02:12:49,819 IN DOWN SYNDROME VERSUS 2174 02:12:49,819 --> 02:12:55,224 AUTOSOMAL DOMINANT DISEASE. 2175 02:12:55,224 --> 02:13:01,831 THIS IS ANOTHER ABCD S PROJECT 2176 02:13:01,831 --> 02:13:02,465 WITH CONTRIBUTIONS FROM INCLUDE 2177 02:13:02,465 --> 02:13:08,003 AS WELL AS NAA DOMINANT 2178 02:13:08,003 --> 02:13:10,639 INHERITED NETWORK. 2179 02:13:10,639 --> 02:13:11,240 WAS LOOKING AT THE TIMING AND 2180 02:13:11,240 --> 02:13:21,750 SPATIAL DISTRIBUTION VERSUS A 2181 02:13:27,623 --> 02:13:27,723 DAD. 2182 02:13:27,723 --> 02:13:28,257 THEY HAVE BEEN DOWNLOADING 2183 02:13:28,257 --> 02:13:28,858 SIBLING CONTROL AND THOSE WITH 2184 02:13:28,858 --> 02:13:30,993 THE VARIANCE AND 169 CONTROLS 2185 02:13:30,993 --> 02:13:38,767 WITH THE RECENT PUBLICATION AND 2186 02:13:38,767 --> 02:13:49,278 ALSO PERIODIC MRI AND POSITRON 2187 02:13:54,550 --> 02:13:55,017 AND THEY FOUND THE AMYLOID 2188 02:13:55,017 --> 02:13:55,584 PLAQUES OCCUR ROUGHLY AT THE 2189 02:13:55,584 --> 02:13:56,151 SAME LEVEL OF THOSE IN DOWN 2190 02:13:56,151 --> 02:13:58,387 SYNDROME AS THOSE WITH A DAD. 2191 02:13:58,387 --> 02:13:58,988 THERE IS THE IMPLICATION THERE 2192 02:13:58,988 --> 02:14:05,094 THAT INDIVIDUALS WITH ADD OR 2193 02:14:05,094 --> 02:14:07,997 DOWN SYNDROME COULD BENEFIT IN 2194 02:14:07,997 --> 02:14:18,507 THE THERAPIES ANOTHER PROJECT 2195 02:14:25,781 --> 02:14:26,282 WITH THE EMERGENCE AND DOWN 2196 02:14:26,282 --> 02:14:27,349 SYNDROME AND TO REDUCE THE 2197 02:14:27,349 --> 02:14:34,390 UNCERTAINTY WITH THE SYMPTOM 2198 02:14:34,390 --> 02:14:34,857 ONSET THE LONGITUDINAL 2199 02:14:34,857 --> 02:14:35,491 EVALUATION BECAUSE THERE IS SUCH 2200 02:14:35,491 --> 02:14:45,100 A WIDE AGE RANGE ONSET OF PEOPLE 2201 02:14:45,100 --> 02:14:45,701 AND 192 PARTICIPANTS OVER THE 2202 02:14:45,701 --> 02:14:46,969 AGE OF 25 WITH DOWN SYNDROME 2203 02:14:46,969 --> 02:14:52,474 HAVE BEEN ENROLLED ALSO GETTING 2204 02:14:52,474 --> 02:14:58,247 PERIODIC MRI AND CAT SCAN AND 2205 02:14:58,247 --> 02:15:01,951 THEN THE INCREASES ARE 2.5 AFTER 2206 02:15:01,951 --> 02:15:04,253 THE ONSET. 2207 02:15:04,253 --> 02:15:12,962 SO THIS COULD PROVIDE THE 2208 02:15:12,962 --> 02:15:13,429 STRATEGY FOR TEMPORAL 2209 02:15:13,429 --> 02:15:14,063 CHARACTERIZATION AND PROGRESSION 2210 02:15:14,063 --> 02:15:14,630 THAT IS SPECIFIC IN THE DOWN 2211 02:15:14,630 --> 02:15:19,301 SYNDROME POPULATION. 2212 02:15:19,301 --> 02:15:20,569 THIS IS A MAJOR CONCERN. 2213 02:15:20,569 --> 02:15:26,308 I PARTICIPATE IN THE MEETINGS 2214 02:15:26,308 --> 02:15:26,909 AND I WOULD SAY OVERWHELMINGLY 2215 02:15:26,909 --> 02:15:30,045 THE PRESENTATIONS ARE ON THE 2216 02:15:30,045 --> 02:15:32,414 AGING POPULATION OF DOWN 2217 02:15:32,414 --> 02:15:36,452 SYNDROME. 2218 02:15:36,452 --> 02:15:43,826 THEY ARE LARGELY POPULATED BY 2219 02:15:43,826 --> 02:15:44,460 PEOPLE WHO ARE ADULTS WITH DOWN 2220 02:15:44,460 --> 02:15:45,094 SYNDROME AND HAVE GREAT CONCERN 2221 02:15:45,094 --> 02:15:45,728 HOW TO TREAT THEM AND TAKE CARE 2222 02:15:45,728 --> 02:15:51,767 OF THEM. 2223 02:15:51,767 --> 02:15:52,368 1 OF THE GREAT ACHIEVEMENTS OF 2224 02:15:52,368 --> 02:16:02,211 THE INCLUDE INITIATIVE WITH THE 2225 02:16:02,211 --> 02:16:02,811 PALPABLE INCREASED INTEREST OF 2226 02:16:02,811 --> 02:16:03,445 TRAINEES IN DOWN SYNDROME IS NOW 2227 02:16:03,445 --> 02:16:06,415 WE HAVE A DATA HUB FUNDED BY 2228 02:16:06,415 --> 02:16:10,853 INCLUDE IT IS CLOUD -BASED 2229 02:16:10,853 --> 02:16:13,389 DEVELOPED BY THE COORDINATING 2230 02:16:13,389 --> 02:16:16,091 CENTER PROVIDING ACCESS TO 2231 02:16:16,091 --> 02:16:20,229 LARGE-SCALE DATA RESOURCES THERE 2232 02:16:20,229 --> 02:16:25,267 IS 74 OR TERABYTES OF DATA AND 2233 02:16:25,267 --> 02:16:25,868 THOUSANDS OF CLINICAL PROFILES 2234 02:16:25,868 --> 02:16:36,311 AND GENOMES IN HUNDREDS OF 2235 02:16:39,615 --> 02:16:40,149 TRANSCRIPT DOMES AND PROTEINS 2236 02:16:40,149 --> 02:16:40,516 THAT METABOLIZE. 2237 02:16:40,516 --> 02:16:41,083 WHAT I HAVE FOUND IN MY OWN 2238 02:16:41,083 --> 02:16:41,650 RESEARCH IS THERE IS SO MUCH 2239 02:16:41,650 --> 02:16:42,217 INFORMATION OUT THERE WITH 2240 02:16:42,217 --> 02:16:49,692 PARTICULARLY THE MOUSE MODELS 2241 02:16:49,692 --> 02:16:50,225 AND THE RAT MODELS OF DOWN 2242 02:16:50,225 --> 02:16:50,993 SYNDROME BUT THERE IS NO WAY TO 2243 02:16:50,993 --> 02:16:54,329 COMPARE THEM IN A LARGE SCALE 2244 02:16:54,329 --> 02:16:57,166 DATA WAY SO NOW WE ARE FUNDING 2245 02:16:57,166 --> 02:16:59,935 ANIMAL DATA AS WELL BUT THE 2246 02:16:59,935 --> 02:17:04,139 WHOLE PURPOSE OF THE DATA HUB IS 2247 02:17:04,139 --> 02:17:09,511 TO PROVIDE DATA FREELY TO ANYONE 2248 02:17:09,511 --> 02:17:10,112 WHO WANTS TO WORK IN THE AREA 2249 02:17:10,112 --> 02:17:11,814 BUT ALSO ENCOURAGES 2250 02:17:11,814 --> 02:17:14,116 COLLABORATION AND SUPPLYING DATA 2251 02:17:14,116 --> 02:17:17,186 TO HAVE A GOOD DATA APPROACH 2252 02:17:17,186 --> 02:17:22,658 LOOKING FOR NEW INSIGHTS THE 2253 02:17:22,658 --> 02:17:27,396 WEBSITE IS AT THE BOTTOM. 2254 02:17:27,396 --> 02:17:30,132 I BELIEVE MY LABORATORY IS THE 2255 02:17:30,132 --> 02:17:40,642 ONLY 1 STUDYING DOWN SYNDROME. 2256 02:17:41,610 --> 02:17:42,144 I'M NOT AWARE OF ANYBODY ELSE 2257 02:17:42,144 --> 02:17:42,811 BUT OUR VISION IS TO TAKE 2258 02:17:42,811 --> 02:17:51,587 PRENATAL SCREENING AND DIAGNOSIS 2259 02:17:51,587 --> 02:17:52,187 THE FIRST AND SECOND TRIMESTER 2260 02:17:52,187 --> 02:17:52,755 OF PREGNANCY BY NONINVASIVE 2261 02:17:52,755 --> 02:17:53,322 PRENATAL TEST AND SEQUENCING 2262 02:17:53,322 --> 02:17:56,258 FRAGMENTS FROM THE PLACENTA VERY 2263 02:17:56,258 --> 02:18:06,769 ACCURATE WE CAN INDEPENDENTLY 2264 02:18:09,538 --> 02:18:10,005 AND THE VISION WOULD BE TO 2265 02:18:10,005 --> 02:18:11,740 PROVIDE SAFE AND EFFECTIVE 2266 02:18:11,740 --> 02:18:18,847 THERAPY TO IMPROVE COGNITION AND 2267 02:18:18,847 --> 02:18:19,414 WOMEN CARRYING FETUSES WITH 2268 02:18:19,414 --> 02:18:22,718 CONFIRM DOWN SYNDROME. 2269 02:18:22,718 --> 02:18:33,262 I KNOW IT SOUNDS A LITTLE CRAZY. 2270 02:18:38,033 --> 02:18:38,500 HAD SOME POSITIVE RESULTS. 2271 02:18:38,500 --> 02:18:39,034 NOT IN HUMANS BUT IN MICE. 2272 02:18:39,034 --> 02:18:39,668 SO IN MY LABORATORY IN THE HUMAN 2273 02:18:39,668 --> 02:18:40,302 GENOME INSTITUTE WE ARE TAKING A 2274 02:18:40,302 --> 02:18:44,173 TWO-PRONGED APPROACH BACK BEFORE 2275 02:18:44,173 --> 02:18:50,879 COMING TO NIH STUDYING AMNIO 2276 02:18:50,879 --> 02:18:51,480 SITES THAT WERE LEFT OVER FROM 2277 02:18:51,480 --> 02:18:52,214 AMNIOCENTESIS -- -- 2278 02:18:52,214 --> 02:18:55,717 AMNIOCENTESIS. 2279 02:18:55,717 --> 02:18:58,253 AND MORE RECENTLY BEEN ABLE TO 2280 02:18:58,253 --> 02:19:08,063 OBTAIN AND CONVERTING THEM AND 2281 02:19:08,063 --> 02:19:08,463 WITH THE CONTROLS. 2282 02:19:08,463 --> 02:19:19,007 AND THE IDEA WITH THE DATABASE. 2283 02:19:24,513 --> 02:19:26,715 THE INITIAL EFFORTS ARE LOOKING 2284 02:19:26,715 --> 02:19:37,125 AT SOME GROWTH THERE IS 2285 02:19:40,696 --> 02:19:41,230 SIGNIFICANT INFORMATION IN THE 2286 02:19:41,230 --> 02:19:41,797 BRAIN AND THE FETUS OF DOWN 2287 02:19:41,797 --> 02:19:42,064 SYNDROME. 2288 02:19:42,064 --> 02:19:42,698 AND THEN WE IDENTIFIED A THERAPY 2289 02:19:42,698 --> 02:19:45,033 MOVING TO THE IN VIVO MODEL. 2290 02:19:45,033 --> 02:19:45,634 PHENOTYPE FOR DIFFERENT MOUSE 2291 02:19:45,634 --> 02:19:47,936 MODELS IN DOWN SYNDROME WITH 2292 02:19:47,936 --> 02:19:49,471 EMBRYONIC DEVELOPMENT 2293 02:19:49,471 --> 02:19:53,475 DEVELOPMENT BODY GROWTH AND 2294 02:19:53,475 --> 02:19:54,276 BRAIN GROWTH AND DEVELOPMENT OF 2295 02:19:54,276 --> 02:19:59,815 THE PLACENTA AND ALSO PRENATAL 2296 02:19:59,815 --> 02:20:00,115 TREATMENT. 2297 02:20:00,115 --> 02:20:03,318 ALSO WITH THE IMPROVEMENT AS 2298 02:20:03,318 --> 02:20:06,521 WELL AS THE MOLECULES IN THE 2299 02:20:06,521 --> 02:20:10,492 PREGNANT DAMS. 2300 02:20:10,492 --> 02:20:11,093 I COULD TALK FOR AN HOUR ABOUT 2301 02:20:11,093 --> 02:20:13,428 THIS BUT I WOULD JUST GIVE YOU A 2302 02:20:13,428 --> 02:20:14,463 FEW SLIDES. 2303 02:20:14,463 --> 02:20:19,668 THE FIRST MOLECULE THE NATURALLY 2304 02:20:19,668 --> 02:20:21,370 I -- -- OCCURRING WHICH WAS 2305 02:20:21,370 --> 02:20:24,740 AVAILABLE FROM A DATABASE KNOWN 2306 02:20:24,740 --> 02:20:32,080 AS THE CONDUCTIVITY MAP. 2307 02:20:32,080 --> 02:20:33,916 OCC 2308 02:20:33,916 --> 02:20:37,986 OCCURS IN LEAFY GREENS AND 2309 02:20:37,986 --> 02:20:41,890 CITRUS. THERE ARE CLINICALS BUT 2310 02:20:41,890 --> 02:20:44,092 IF YOU ARE GOING TO GIVE 2311 02:20:44,092 --> 02:20:45,060 SOMETHING TO A PREGNANT PERSON 2312 02:20:45,060 --> 02:20:46,862 YOU HAVE A MUCH HIGHER BAR TO 2313 02:20:46,862 --> 02:20:50,365 GET OVER. IT IS A POTENT 2314 02:20:50,365 --> 02:20:52,034 ANTIOXIDANT AND HAS 2315 02:20:52,034 --> 02:20:54,303 ANTI-INFLAMMATORY EFFECTS AND 2316 02:20:54,303 --> 02:20:55,604 CROSSES THE BLOOD-BRAIN BARRIER 2317 02:20:55,604 --> 02:21:01,410 IN ANIMALS AND PROMOTES 2318 02:21:01,410 --> 02:21:02,978 NEUROGENESIS, SOMETHING IN 2319 02:21:02,978 --> 02:21:04,646 DOWN'S SYNDROME. WE HAVE DONE 2320 02:21:04,646 --> 02:21:07,683 STUDIES BOTH IN HUMAN CELLS AND 2321 02:21:07,683 --> 02:21:11,186 MICE THAT ARE PRE-PREGNANT WE 2322 02:21:11,186 --> 02:21:13,889 PUT THE DAM WITH THE MALE AND 2323 02:21:13,889 --> 02:21:16,959 FEED THEM THIS FROM TIME OF 2324 02:21:16,959 --> 02:21:20,862 MATING... NEXT SLIDE. SO WE HAVE 2325 02:21:20,862 --> 02:21:23,231 ALREADY PUBLISHED THIS ACTUALLY 2326 02:21:23,231 --> 02:21:26,501 DOES POSITIVE THINGS SO WE HAVE 2327 02:21:26,501 --> 02:21:30,072 HAD A PRINCIPAL PUBLICATION, 2328 02:21:30,072 --> 02:21:36,244 AMERICAN JOURNAL OF HUMAN 2329 02:21:36,244 --> 02:21:40,482 GENETICS. IT WILL RESCUE 2330 02:21:40,482 --> 02:21:42,851 OVER-EXPRESSION. I HAVE SHOWN 2331 02:21:42,851 --> 02:21:46,555 YOU GENES BUT THESE ARE IN THE 2332 02:21:46,555 --> 02:21:49,324 FOREBRAIN. THE BLACK TRIANGLE IS 2333 02:21:49,324 --> 02:21:51,526 THE DOWN SYNDROME MOUSE THAT HAS 2334 02:21:51,526 --> 02:21:53,762 BEEN -- WAS JUST FED WITH 2335 02:21:53,762 --> 02:21:59,801 REGULAR POWDER. THEN FOLLOWING 2336 02:21:59,801 --> 02:22:02,070 TREATMENT WITH APIGEN THAT SHOWS 2337 02:22:02,070 --> 02:22:03,739 HOW THE EXPRESSION OF THIS GENE 2338 02:22:03,739 --> 02:22:07,576 IS MORE AT LEVEL OF THE UPLOID 2339 02:22:07,576 --> 02:22:10,412 OR WILD TYPE MICE. SIMILARLY 2340 02:22:10,412 --> 02:22:20,956 ANTI -INFLAMMATORY PSYTOCHINES 2341 02:22:21,823 --> 02:22:27,929 IS PRESENT TO PREVENT INF 2342 02:22:27,929 --> 02:22:29,698 INFLAMMATION. WE DID A BUNCH OF 2343 02:22:29,698 --> 02:22:33,468 MOUSE BEHAVIORAL STUDIES THAT 2344 02:22:33,468 --> 02:22:36,371 SHOWED SIGNIFICANT IMPROVEMENT 2345 02:22:36,371 --> 02:22:42,778 IN ADULT MICE TESTED BUT SAW 2346 02:22:42,778 --> 02:22:45,680 INTERESTING SEX DIFFERENCE WHERE 2347 02:22:45,680 --> 02:22:47,149 THE RESPONSE WAS HIGHER IN MALES 2348 02:22:47,149 --> 02:22:50,619 THAN FEMALES. I WANT TO MENTION 2349 02:22:50,619 --> 02:22:52,888 BECAUSE THIS WILL GET INTO THE 2350 02:22:52,888 --> 02:22:58,060 OTHER PART, WE ARE VERY INTER 2351 02:22:58,060 --> 02:22:58,527 TES 2352 02:22:58,527 --> 02:23:01,763 INTERESTED IN PLACENTA. WE ARE 2353 02:23:01,763 --> 02:23:04,132 BLOWN AWAY BY EXPRESSION OF APP. 2354 02:23:04,132 --> 02:23:07,202 WE KNOW IT IS EXPRESSED IN 2355 02:23:07,202 --> 02:23:12,140 MULTIPLE ORGANS. BUT WITH 2356 02:23:12,140 --> 02:23:14,843 IMMUNOHISTO CHEMICAL EXPERIMENT, 2357 02:23:14,843 --> 02:23:16,178 FAIRLY RECENT THAT, IS WHY I'M 2358 02:23:16,178 --> 02:23:18,680 NOT SHOWING YOU A PICTURE, IT 2359 02:23:18,680 --> 02:23:22,517 STRIKING HOW MUCH MORE STRONGLY 2360 02:23:22,517 --> 02:23:27,689 EXPRESSED APP IS IN MOUSE MODELS 2361 02:23:27,689 --> 02:23:30,258 OF DOWN'S SYNDROME. SIMILARLY IN 2362 02:23:30,258 --> 02:23:33,295 THE HUMAN PLACENTA, THERE ARE 2363 02:23:33,295 --> 02:23:34,463 FUNDAMENTAL DIFFERENCES, THE 2364 02:23:34,463 --> 02:23:35,831 MAIN ONE BEING IF YOU LOOK ON 2365 02:23:35,831 --> 02:23:44,406 THE RIGHT WHERE IT SAYS UPLOID 2366 02:23:44,406 --> 02:23:50,078 THE CELLS HAVE TO FUSE. THIS 2367 02:23:50,078 --> 02:23:51,680 MAKES THE HORMONES CENTRAL TO 2368 02:23:51,680 --> 02:23:58,720 THE PREGNANCY. IF YOU LOOK AT 2369 02:23:58,720 --> 02:24:04,159 THAT UPLOID YOU CAN SEE THE 2370 02:24:04,159 --> 02:24:07,429 GREEN DOTS AND CELLULAR 2371 02:24:07,429 --> 02:24:09,331 MEMBRANES, THE NORMAL. IF YOU 2372 02:24:09,331 --> 02:24:11,666 LOOK ABOVE THIS DOES NOT FUSE IN 2373 02:24:11,666 --> 02:24:17,873 THE WAY IT IS SUPPOSED TO 2374 02:24:17,873 --> 02:24:21,009 RESULTING IN DECREASED HORMONES. 2375 02:24:21,009 --> 02:24:22,744 PLACENTA HAS NORMAL 2376 02:24:22,744 --> 02:24:26,648 ABNORMALITIES IN TRISMI21. WE 2377 02:24:26,648 --> 02:24:31,820 THINK IF WE UNDERSTAND FOR 2378 02:24:31,820 --> 02:24:33,188 EXAMPLE WHETHER PREMATURE AGING 2379 02:24:33,188 --> 02:24:35,457 OF PLACENTA PLAYS ROLE LONG-TERM 2380 02:24:35,457 --> 02:24:38,326 THIS MAY HELP US UNDERSTAND WHY 2381 02:24:38,326 --> 02:24:40,095 PEOPLE WITH DOWN SYNDROME AGE 2382 02:24:40,095 --> 02:24:40,996 PREMATURELY AND WHETHER OR NOT 2383 02:24:40,996 --> 02:24:45,066 THERE IS A CONNECTION WITH 2384 02:24:45,066 --> 02:24:52,174 ALZHEIMER'S LATER ON. THAT 2385 02:24:52,174 --> 02:24:54,342 BRINGS US TO CONNECTIONS BETWEEN 2386 02:24:54,342 --> 02:24:58,013 PLACENTA AND FETUS LONG-TERM. I 2387 02:24:58,013 --> 02:25:00,348 HAVE ALWAYS BEEN INTERESTED IN 2388 02:25:00,348 --> 02:25:03,552 KNEE NA SHORE THE DIRECTOR 2389 02:25:03,552 --> 02:25:14,196 ACROSS THE NIH. SHE WROTE A 2390 02:25:17,432 --> 02:25:27,142 PAPER AND HI POT SIS SHOWS THE 2391 02:25:27,142 --> 02:25:29,744 PROTEIN IMPLICATION. THERE IS 2392 02:25:29,744 --> 02:25:32,080 EVIDENCE THIS PLAYS MAJOR ROLES 2393 02:25:32,080 --> 02:25:37,719 IN BRAIN DREVELOPMENT. THE ORIGN 2394 02:25:37,719 --> 02:25:40,488 IS THIS MAY BE PRESENT. THERE IS 2395 02:25:40,488 --> 02:25:42,424 A GREAT OPPORTUNITY TO 2396 02:25:42,424 --> 02:25:44,025 COLLABORATE HAS INSTITUTES. 2397 02:25:44,025 --> 02:25:46,328 PEOPLE LAUGH WHEN I SAY AGING 2398 02:25:46,328 --> 02:25:49,731 BEGINS IN THE WOMB BUT IT REALLY 2399 02:25:49,731 --> 02:25:52,667 DOES. WE COULD, FOR SURE, CREATE 2400 02:25:52,667 --> 02:25:55,237 MODEL SYSTEMS TO FACILITATE 2401 02:25:55,237 --> 02:25:59,441 PROTEINS, NETWORK STRUCTURE AND 2402 02:25:59,441 --> 02:26:03,678 FUNCTION, LOOKING AT EMBRYO 2403 02:26:03,678 --> 02:26:10,719 GENESIS THROUGH SYNESIS AND DO 2404 02:26:11,019 --> 02:26:13,688 EMBRYONIC STUDIES. I WANT TO 2405 02:26:13,688 --> 02:26:15,924 MENTION IN THE STRATEGIC PLAN, 2406 02:26:15,924 --> 02:26:18,260 REFRESHED FOR THE NEXT FIVE-YEAR 2407 02:26:18,260 --> 02:26:22,430 CYCLE WE SINGLED OUT 2408 02:26:22,430 --> 02:26:23,832 NEURODEVELOPMENT TO 2409 02:26:23,832 --> 02:26:30,505 NEURODEGENERATION WITHES A P 2410 02:26:30,505 --> 02:26:33,675 ASPIRATIONAL GOAL TO ESTABLISH 2411 02:26:33,675 --> 02:26:35,210 LIKELIHOOD OF THESE DISORDERS 2412 02:26:35,210 --> 02:26:38,546 LATER IN LIFE. NEXT SLIDE, 2413 02:26:38,546 --> 02:26:40,148 PLEASE. I THINK IN THE INTEREST 2414 02:26:40,148 --> 02:26:42,951 OF TIME I'M NOT GOING TO GO OVER 2415 02:26:42,951 --> 02:26:47,222 THIS. WE HAVE TEN ASPIRATIONAL 2416 02:26:47,222 --> 02:26:49,057 GOALS. FOR OUR ADVISORY COUNCIL, 2417 02:26:49,057 --> 02:26:53,061 EARLIER THIS WEEK, WE HAVE BEEN 2418 02:26:53,061 --> 02:27:01,770 REVIEWING THOSE TEN GOALS IN 2419 02:27:01,770 --> 02:27:06,941 ANTICIPATION OF THE REFRESH AND 2420 02:27:06,941 --> 02:27:08,276 PROGRESS. WE HAVE MADE PROGRESS. 2421 02:27:08,276 --> 02:27:10,011 I WILL MAKE THEM AVAILABLE FOR 2422 02:27:10,011 --> 02:27:14,849 YOUR READING AFTER THE COUNCIL 2423 02:27:14,849 --> 02:27:18,386 SO YOU CAN TAKE A LOOK. FUNDING 2424 02:27:18,386 --> 02:27:19,387 HAS ESSENTIALLY REMAINED FLAT 2425 02:27:19,387 --> 02:27:22,791 WITH A LITTLE BUMP NEXT YEAR. 2426 02:27:22,791 --> 02:27:24,292 NEXT SLIDE. YOU CAN ALREADY TELL 2427 02:27:24,292 --> 02:27:26,695 I'M A BIG FAN OF THE PLACENTA, 2428 02:27:26,695 --> 02:27:29,597 WHICH WE JOKINGLY REFER TO AS 2429 02:27:29,597 --> 02:27:31,199 NICHD'S ORGAN. WE HAVE ALWAYS 2430 02:27:31,199 --> 02:27:32,600 BEEN CONNECTED TO A PLACENTA AT 2431 02:27:32,600 --> 02:27:35,804 ONE TIME. IT IS AN AMAZING ORGAN 2432 02:27:35,804 --> 02:27:39,307 THAT BASICALLY'S FUNCTIONS AS 2433 02:27:39,307 --> 02:27:42,577 YOUR HEART, YOUR LUNGS, YOUR 2434 02:27:42,577 --> 02:27:49,584 BRAIN, YOUR IND IN/* ENDOCRINE 2435 02:27:49,584 --> 02:27:52,153 SYSTEM AND PLAYS A LIFE-LONG 2436 02:27:52,153 --> 02:27:54,222 ROLE. PART OF OUR STUDY IS 2437 02:27:54,222 --> 02:27:56,624 INTERESTED IN ORIGINS OF DISEASE 2438 02:27:56,624 --> 02:28:00,428 AND ESPECIALLY ROLE OF HARMFUL 2439 02:28:00,428 --> 02:28:06,067 EXPOSURES IN UTERO AND DISEASE 2440 02:28:06,067 --> 02:28:09,537 LATER IN LIFE. WE HAVE 2441 02:28:09,537 --> 02:28:11,673 INVESTIGATED 90 MILLION IN THE 2442 02:28:11,673 --> 02:28:13,041 PROJECT. WHAT MAKES THAT PROJECT 2443 02:28:13,041 --> 02:28:14,909 UNIQUE IS IT IS LOOKING AT 2444 02:28:14,909 --> 02:28:17,779 DEVELOPMENT AND FUNCTION OF THE 2445 02:28:17,779 --> 02:28:22,617 PLACENTA BUT REALTIME AND 2446 02:28:22,617 --> 02:28:26,454 NONINVASIVE, SO IT IS REALLY 2447 02:28:26,454 --> 02:28:28,156 CREATED A NUMBER OF IMAGING 2448 02:28:28,156 --> 02:28:30,592 PROTOCOLS THAT ALLOW US TO LOOK 2449 02:28:30,592 --> 02:28:34,095 AT BLOOD FLOW, OXYGEN 2450 02:28:34,095 --> 02:28:36,631 DISTRIBUTION, LABELED NUTRIENT 2451 02:28:36,631 --> 02:28:47,375 FLOWS AND BIG EMPHASIS ON IN 2452 02:28:47,675 --> 02:28:50,245 NUCLEIC ACID. I MENTION DASH, 2453 02:28:50,245 --> 02:28:52,380 THE FUNDED DATA AND SPECIMEN 2454 02:28:52,380 --> 02:28:56,184 HUB. THIS IS A CENTRALIZED 2455 02:28:56,184 --> 02:28:58,086 RESOURCE FOR RESEARCHERS. IT IS 2456 02:28:58,086 --> 02:28:59,854 A GREAT OPPORTUNITY IF SOMEBODY 2457 02:28:59,854 --> 02:29:02,056 WANTED TO LOOK AT CERTAIN 2458 02:29:02,056 --> 02:29:04,759 MARKERS THAT YOU KNOW ARE 2459 02:29:04,759 --> 02:29:06,327 ASSOCIATED WITH 2460 02:29:06,327 --> 02:29:08,596 NEURODEGENERATION FOR EXAMPLE, 2461 02:29:08,596 --> 02:29:10,098 YOU COULD GET CORE BLOOD TODAY 2462 02:29:10,098 --> 02:29:17,806 OR TOMORROW IF YOU JUST REGI 2463 02:29:17,806 --> 02:29:20,442 REGISTERED WITH THIS RESOURCE. 2464 02:29:20,442 --> 02:29:22,610 IT PROVIDES A TREMENDOUS AMOUNT 2465 02:29:22,610 --> 02:29:25,880 OF DATA THAT'S BEEN CLEANED, NO 2466 02:29:25,880 --> 02:29:28,116 NEED TO GO THROUGH IRB. IT IS 2467 02:29:28,116 --> 02:29:29,884 WONDERFUL FOR TESTING 2468 02:29:29,884 --> 02:29:32,153 HYPOTHESES. IT IS USED PRETTY 2469 02:29:32,153 --> 02:29:34,222 HEAVILY. THERE HAVE BEEN 662 2470 02:29:34,222 --> 02:29:36,958 DATA REQUESTS AS OF LAST WEEK. 2471 02:29:36,958 --> 02:29:42,397 THERE HAVE ALREADY BEEN 106 DATA 2472 02:29:42,397 --> 02:29:46,367 USE PUBLICATIONS. NEXT SLIDE, 2473 02:29:46,367 --> 02:29:48,403 PLEASE. I WILL WANT TO 2474 02:29:48,403 --> 02:29:49,804 ACKNOWLEDGE ANOTHER AREA WHERE 2475 02:29:49,804 --> 02:29:51,606 WE ARE ALREADY PARTNERING. BUT 2476 02:29:51,606 --> 02:29:53,608 THERE WOULD CERTAINLY BE MORE 2477 02:29:53,608 --> 02:29:57,479 OPPORTUNITIES TO PARTNER. SO 2478 02:29:57,479 --> 02:30:01,216 THIS IS ADD HEALTH, THE 2479 02:30:01,216 --> 02:30:05,887 LONGITUDINAL STUDY OFSADOLESCEN 2480 02:30:05,887 --> 02:30:08,890 TO ADULT HEALTH. IT WAS LAUNCHED 2481 02:30:08,890 --> 02:30:11,359 IN GREAT 7-12. THERE HAVE BEEN 2482 02:30:11,359 --> 02:30:13,394 FIVE WAVES OF DATA. THE 2483 02:30:13,394 --> 02:30:15,363 OBJECTIVE OF WAVE FIVE WAS TO 2484 02:30:15,363 --> 02:30:17,866 UNDERSTAND EARLY LIFE PRECURSORS 2485 02:30:17,866 --> 02:30:21,202 OF CHRONIC DISEASE. WAVE SIX, 2486 02:30:21,202 --> 02:30:23,304 WHICH NIA IS SUPPORTING, 2487 02:30:23,304 --> 02:30:25,540 INCLUDES MEASURES FOR COGNITION 2488 02:30:25,540 --> 02:30:27,208 AND AIMS TO FACILITATE 2489 02:30:27,208 --> 02:30:30,011 IDENTIFICATION OF EARLY RISK 2490 02:30:30,011 --> 02:30:31,946 FACTORS FOR DEMENTIA. EXCUSE ME. 2491 02:30:31,946 --> 02:30:35,650 SO THIS IS REALLY A UNIQUE 2492 02:30:35,650 --> 02:30:37,886 OPPORTUNITY TO BE ABLE TO LINK 2493 02:30:37,886 --> 02:30:39,487 DATA FROM WHAT YOU WERE DOING IN 2494 02:30:39,487 --> 02:30:40,488 HIGH SCHOOL SO LIKE WERE YOU 2495 02:30:40,488 --> 02:30:48,096 TAKING DRUGS, FOR EXAMPLE. WHAT 2496 02:30:48,096 --> 02:30:49,664 DOES THAT MEAN FOR YOUR 2497 02:30:49,664 --> 02:30:51,699 LONG-TERM HEALTH. IT ALSO 2498 02:30:51,699 --> 02:30:54,736 INCLUDES INFORMATION ABOUT THE 2499 02:30:54,736 --> 02:30:57,505 RESPONDENT'S NEIGHBORHOODS A 2500 02:30:57,505 --> 02:30:59,007 COMMUNITIES AND SOCIAL FACTORS 2501 02:30:59,007 --> 02:31:01,142 THAT ARE SO IMPORTANT. YOU KNOW, 2502 02:31:01,142 --> 02:31:03,578 WE ARE VERY GRATEFUL THAT NIA 2503 02:31:03,578 --> 02:31:05,647 HAS ESSENTIALLY TAKEN OVER AS 2504 02:31:05,647 --> 02:31:10,385 THE PARTICIPANTS HAVE AGED OUT 2505 02:31:10,385 --> 02:31:14,188 OF OUR FOCUS GROUPS BUT WE HAVE 2506 02:31:14,188 --> 02:31:15,223 OTHER OPPORTUNITIES. WE ALWAYS 2507 02:31:15,223 --> 02:31:17,525 HAVE MANY PEOPLE REQUESTING, FOR 2508 02:31:17,525 --> 02:31:19,160 EXAMPLE, PREGNANCY AS A STRESS 2509 02:31:19,160 --> 02:31:22,931 TEST FOR LATER HEALTH. SO WE 2510 02:31:22,931 --> 02:31:33,474 HAVE TREMENDOUS DATA BUT DON'T 2511 02:31:35,076 --> 02:31:37,779 ALWAYS FOLLOW. SPEAKING OF 2512 02:31:37,779 --> 02:31:39,781 PREGNANCY, MENOPAUSE IS HAVING A 2513 02:31:39,781 --> 02:31:41,449 MOMENT. THERE IS CONGRESSIONAL 2514 02:31:41,449 --> 02:31:44,652 INTEREST. APPEARS IN LEGISLATION 2515 02:31:44,652 --> 02:31:47,789 AND MENTIONED AT NIH HEARINGS. 2516 02:31:47,789 --> 02:31:49,824 WE KNOW NIA FUNDS MAJORITY OF 2517 02:31:49,824 --> 02:31:54,996 RESEARCH MANY MENOPAUSE. WE FUND 2518 02:31:54,996 --> 02:31:56,297 SOME. WOULD LIKE TO FUND MORE 2519 02:31:56,297 --> 02:32:00,001 AND LOOK AT SOME OF THE 2520 02:32:00,001 --> 02:32:01,669 COMPLICATIONS IN WOMEN'S 2521 02:32:01,669 --> 02:32:03,104 REPRODUCTIVE BIOLOGY. WE ALSO 2522 02:32:03,104 --> 02:32:13,648 KNOW THERE ARE ECONOMIC AND WORK 2523 02:32:13,848 --> 02:32:16,317 FACTORS WITH HAVING SEVERE 2524 02:32:16,317 --> 02:32:17,518 SYMPTOMS IN WORKPLACE. THIS IS 2525 02:32:17,518 --> 02:32:20,989 THE SOCIETY FOR WOMEN'S HEALTH 2526 02:32:20,989 --> 02:32:23,124 RESEARCH. THAT BRINGS UP THE 2527 02:32:23,124 --> 02:32:24,792 RECENT PRESIDENTIAL MEMORANDUM, 2528 02:32:24,792 --> 02:32:29,664 THE WOMEN'S HEALTH RESEARCH 2529 02:32:29,664 --> 02:32:30,264 INITIATIVE. LAST NOVEMBER 2530 02:32:30,264 --> 02:32:33,267 PRESIDENT BIDEN ANNOUNCED THE 2531 02:32:33,267 --> 02:32:35,136 FIRST INITIATIVE ON WOMEN'S 2532 02:32:35,136 --> 02:32:38,439 HEALTH RESEARCH, LED BY FIRST 2533 02:32:38,439 --> 02:32:40,608 LADY DR. JILL BIDEN AND WHITE 2534 02:32:40,608 --> 02:32:50,551 HOUSE GENDER POLICY COUNCIL. IT 2535 02:32:50,551 --> 02:32:54,522 IS TO DELIVER RECOMMENDATIONS TO 2536 02:32:54,522 --> 02:32:57,759 AFFECT WOMEN'S RESEARCH AND HIGH 2537 02:32:57,759 --> 02:33:02,463 TARGET AREAS WHERE THIS COULD BE 2538 02:33:02,463 --> 02:33:03,064 TRANSF 2539 02:33:03,064 --> 02:33:03,798 TRANSFORMATIVE. THEY ARE NOT 2540 02:33:03,798 --> 02:33:06,100 GIVING US MONEY NOW BUT WANT OUR 2541 02:33:06,100 --> 02:33:11,339 IDEAS, ENGAGING THE SCIENTIFIC 2542 02:33:11,339 --> 02:33:14,108 AND PHILANTHROPIC COMMUNITIES. 2543 02:33:14,108 --> 02:33:15,777 IT IS CLEAR THE NIH HAS BEEN 2544 02:33:15,777 --> 02:33:18,613 ASKED TO TAKE THE LEAD ON 2545 02:33:18,613 --> 02:33:20,314 RECOMMENDATIONS ON RESEARCH. WE 2546 02:33:20,314 --> 02:33:27,355 WERE ALL ASKED TO CONTRIBUTE TO 2547 02:33:27,355 --> 02:33:28,589 GOVERNMENT-WIDE RECOMMENDATIONS 2548 02:33:28,589 --> 02:33:30,525 SUBMITTED DECEMBER 28TH. 2549 02:33:30,525 --> 02:33:32,593 APPARENTLY THE FIRST LADY WAS 2550 02:33:32,593 --> 02:33:34,262 QUITE PLEASED WITH SOME OF OUR 2551 02:33:34,262 --> 02:33:35,663 IDEAS. WE WANTED TO MAKE SURE 2552 02:33:35,663 --> 02:33:39,801 SOME OF THE CONDITIONS UNIQUE TO 2553 02:33:39,801 --> 02:33:43,805 PEOPLE BORN FEMALE WERE 2554 02:33:43,805 --> 02:33:45,239 INCLOUDED. 2555 02:33:45,239 --> 02:33:46,607 INCLOUDED. -- INCLUDED. THEY 2556 02:33:46,607 --> 02:33:49,143 WERE. IT IS UP IN THE AIR 2557 02:33:49,143 --> 02:33:50,511 WHETHER ANYTHING RELATED TO 2558 02:33:50,511 --> 02:33:51,979 PREGNANCY IS GOING TO BE 2559 02:33:51,979 --> 02:33:53,414 INCLUDED IN THIS INITIATIVE. WE 2560 02:33:53,414 --> 02:33:57,085 THINK IT IS IMPORTANT TO INCLUDE 2561 02:33:57,085 --> 02:33:58,619 PREGNANCY. IT IS A TIME WHEN 2562 02:33:58,619 --> 02:34:00,521 PEOPLE BORN FEMALE ARE IN TOUCH 2563 02:34:00,521 --> 02:34:02,256 WITH THE HEALTH CARE SYSTEM BUT 2564 02:34:02,256 --> 02:34:03,991 ALSO, AS I SAID EARLIER, A 2565 02:34:03,991 --> 02:34:06,527 STRESS TEST FOR LATER HEALTH. 2566 02:34:06,527 --> 02:34:10,598 NEXT SLIDE, PLEASE. SO IN 2567 02:34:10,598 --> 02:34:16,738 SUMMARY, NIA AND NICHD SHARE 2568 02:34:16,738 --> 02:34:19,640 MANY INTERESTS AND LIFE CORE 2569 02:34:19,640 --> 02:34:21,109 PERSPECTIVE. I THINK THAT REALLY 2570 02:34:21,109 --> 02:34:24,345 STARTED THE DAY WE WERE 2571 02:34:24,345 --> 02:34:30,218 AUTHORIZED AS INSTITUTES. WE'VE 2572 02:34:30,218 --> 02:34:32,887 HAD A FRUITFUL COLLABORATION VIA 2573 02:34:32,887 --> 02:34:33,888 INCLUDE AND PROGRAM OFFICIALS AT 2574 02:34:33,888 --> 02:34:37,558 INCLUDE HAVE BEEN A TOTAL JOY TO 2575 02:34:37,558 --> 02:34:42,130 WORK WITH. WE REALLY ENJOY 2576 02:34:42,130 --> 02:34:50,304 SUPPORTING THE ABCDS WITH YOU. 2577 02:34:50,304 --> 02:34:53,307 WE DO THINK THERE WILL BE FUTURE 2578 02:34:53,307 --> 02:34:54,942 RESEARCH OPPORTUNITIES WITH THIS 2579 02:34:54,942 --> 02:34:56,144 LIFETIME PERSPECTIVE ON HEALTH 2580 02:34:56,144 --> 02:34:58,579 AND TYPICAL AGING SUCH AS IN THE 2581 02:34:58,579 --> 02:35:02,049 ADD HEALTH INITIATIVE. BUT ALSO 2582 02:35:02,049 --> 02:35:03,785 THERE ARE OPPORTUNITIES 2583 02:35:03,785 --> 02:35:05,153 INCLUDING MENOPAUSE. WE ARE 2584 02:35:05,153 --> 02:35:08,689 INTERESTED IN CO -SUPPORTING 2585 02:35:08,689 --> 02:35:10,958 MENOPAUSE RESEARCH WITH YOU. I 2586 02:35:10,958 --> 02:35:12,894 HOPE I HAVE TWEAKED A LITTLE 2587 02:35:12,894 --> 02:35:14,662 INTEREST IN PLACENTA, 2588 02:35:14,662 --> 02:35:18,232 DEVELOPMENTAL ORGANS OF HEALTH 2589 02:35:18,232 --> 02:35:19,634 AND DISEASE. THEN OPPORTUNITIES 2590 02:35:19,634 --> 02:35:21,602 TO DETERMINE IF EARLY 2591 02:35:21,602 --> 02:35:23,004 INTERVENTIONS, EITHER IF THEY 2592 02:35:23,004 --> 02:35:25,907 OCCUR PRE-NATALLY OR EARLY 2593 02:35:25,907 --> 02:35:28,876 CHILDHOOD AFFECT LONG-TERM 2594 02:35:28,876 --> 02:35:30,678 HEALTH. SO I THINK THAT IS IT. I 2595 02:35:30,678 --> 02:35:33,014 HAVE LEFT TIME. I KNOW WE 2596 02:35:33,014 --> 02:35:34,615 STARTED LATE. I HAVE LEFT TIME 2597 02:35:34,615 --> 02:35:36,250 FOR QUESTIONS. I ASSUME WE HAVE 2598 02:35:36,250 --> 02:35:38,019 TEN MINUTES FOR QUESTIONS, SO 2599 02:35:38,019 --> 02:35:39,854 THANK YOU FOR YOUR ATTENTION. 2600 02:35:39,854 --> 02:35:40,121 2601 02:35:40,121 --> 02:35:42,256 >> DIANE, THANK YOU SO MUCH. 2602 02:35:42,256 --> 02:35:43,858 SO MANY AREAS FOR QUESTIONS. I 2603 02:35:43,858 --> 02:35:46,894 GET TO TALK TO YOU MORE 2604 02:35:46,894 --> 02:35:49,030 FREQUENTLY THAN COUNCIL MEMBERS. 2605 02:35:49,030 --> 02:35:51,532 LET ME START BY GIVING PRIORITY 2606 02:35:51,532 --> 02:35:53,134 TO QUESTIONS COUNCIL MEMBERS MAY 2607 02:35:53,134 --> 02:36:00,107 HAVE. IF THERE IS TIME. FRANK. 2608 02:36:00,107 --> 02:36:01,242 >> THANK YOU FOR THE GREAT 2609 02:36:01,242 --> 02:36:04,145 TALK. SO MANY GREAT LESSONS. I'M 2610 02:36:04,145 --> 02:36:06,714 CURIOUS ABOUT THIS OVERLAP OF 2611 02:36:06,714 --> 02:36:09,183 AIMING. DOWN'S SEEMS LIKE SUCH A 2612 02:36:09,183 --> 02:36:10,451 POWERFUL PROTOTYPE BUT HAS THIS 2613 02:36:10,451 --> 02:36:15,623 COME UP IN A LOT OF THER E OTHE 2614 02:36:15,623 --> 02:36:20,127 AREAS? I HAVE A SISTER WITH 2615 02:36:20,127 --> 02:36:24,999 CEREBRAL PALSY, STATIC MOTOR... 2616 02:36:24,999 --> 02:36:27,802 IF YOU LOOK UP THAT DISEASE, 99% 2617 02:36:27,802 --> 02:36:30,004 WILL BE PEDIATRIC-BASED. HOW 2618 02:36:30,004 --> 02:36:31,472 THESE PEOPLE DEAL WITH AGING, 2619 02:36:31,472 --> 02:36:33,307 HOW AGING AFFECTS IT. WHETHER 2620 02:36:33,307 --> 02:36:34,809 THERE IS ACCELERATED AGING OR 2621 02:36:34,809 --> 02:36:37,111 NOT. SO IF I WERE TO APPLY FOR A 2622 02:36:37,111 --> 02:36:39,881 GRANT TO INVESTIGATE AGING IN 2623 02:36:39,881 --> 02:36:42,350 CEREBRAL PALSY, WHAT WOULD 2624 02:36:42,350 --> 02:36:44,285 HAPPEN? WOULD I FALL THROUGH THE 2625 02:36:44,285 --> 02:36:47,655 CRACKS? WHO WOULD I GO TO? HAS 2626 02:36:47,655 --> 02:36:48,923 THIS PLATFORM BEEN SET UP TO 2627 02:36:48,923 --> 02:36:50,191 DEAL WITH THIS OVERLAP? 2628 02:36:50,191 --> 02:36:52,460 >> YAH, SO OFF THE TOP OF MY 2629 02:36:52,460 --> 02:36:55,596 HEAD, I'M NOT AWARE OF SOMETHING 2630 02:36:55,596 --> 02:36:58,633 SPECIFICALLY LOOKING AT AGING IN 2631 02:36:58,633 --> 02:36:59,734 CEREBRAL PALSY; THEREFORE IT IS 2632 02:36:59,734 --> 02:37:01,836 A GAP. I THINK THE LOGICAL PLACE 2633 02:37:01,836 --> 02:37:03,271 TO GO WOULD BE NATIONAL CENTER 2634 02:37:03,271 --> 02:37:05,172 FOR MEDICAL REHABILITATION 2635 02:37:05,172 --> 02:37:07,742 RESEARCH. THEY FUND THE MAJORITY 2636 02:37:07,742 --> 02:37:10,444 OF RESEARCH ON CEREBRAL PALSY. I 2637 02:37:10,444 --> 02:37:20,121 THINK SOME IS ALSO AT NINDS. I 2638 02:37:20,121 --> 02:37:21,455 THINK AGAIN IT IS THIS NATURAL 2639 02:37:21,455 --> 02:37:24,058 HISTORY -- AGAIN, I'M NOT AN 2640 02:37:24,058 --> 02:37:25,826 EXPERT IN THIS AREA BUT I THINK 2641 02:37:25,826 --> 02:37:27,795 IT COULD VERY WELL BE A GAP 2642 02:37:27,795 --> 02:37:28,029 AREA. 2643 02:37:28,029 --> 02:37:29,931 >> YAH, I DON'T WANT TO 2644 02:37:29,931 --> 02:37:31,999 HIGHLIGHT THAT GIVEN DISORDER 2645 02:37:31,999 --> 02:37:34,535 BUT AS AN EXAMPLE OF THINGS WE 2646 02:37:34,535 --> 02:37:36,971 CONSIDER CHILDHOOD OR PEDIATRIC 2647 02:37:36,971 --> 02:37:39,874 DISORDERS PROBABLY HAVE 2648 02:37:39,874 --> 02:37:42,143 BIOLOGICALLY CRITICAL COMPONENTS 2649 02:37:42,143 --> 02:37:44,011 OF AGING-RELATED MECHANISMS, SO 2650 02:37:44,011 --> 02:37:46,147 I THINK YOU ARE REMINDING ME, AT 2651 02:37:46,147 --> 02:37:47,214 LEAST, OF THAT. HOW IMPORTANT 2652 02:37:47,214 --> 02:37:51,552 THIS IS. I GUESS IT IS A KEY 2653 02:37:51,552 --> 02:37:53,988 ROLE FOR NIA TO DEAL WITH THESE 2654 02:37:53,988 --> 02:37:56,424 AGING ASPECTS ACROSS THE WHOLE 2655 02:37:56,424 --> 02:37:57,625 SPECTRUM. IT IS FUNNY TO SAY 2656 02:37:57,625 --> 02:37:59,427 THAT, DEAL WITH AGING ACROSS THE 2657 02:37:59,427 --> 02:38:01,162 ENTIRE LIFE SPAN, RIGHT? 2658 02:38:01,162 --> 02:38:03,064 >> BUT MY POINT IS THAT THERE 2659 02:38:03,064 --> 02:38:04,966 MAY BE CLUES EARLIER IN LIFE 2660 02:38:04,966 --> 02:38:07,802 THAT EITHER IDENTIFY PEOPLE AT 2661 02:38:07,802 --> 02:38:11,138 RISK OR MIGHT GIVE US NEW 2662 02:38:11,138 --> 02:38:13,407 KNOWLEDGE ABOUT INNOVATIVE 2663 02:38:13,407 --> 02:38:14,608 THERAPIES, SO THAT IS WHY IT IS 2664 02:38:14,608 --> 02:38:18,079 AN OPPORTUNITY FOR PARTNERSHIP. 2665 02:38:18,079 --> 02:38:18,980 >> THANK YOU. 2666 02:38:18,980 --> 02:38:20,548 >> WE CERTAINLY RECOGNIZE, 2667 02:38:20,548 --> 02:38:22,750 APPRECIATE WORKING WITH NICHD. 2668 02:38:22,750 --> 02:38:24,618 THERE HAVE BEEN A NUMBER OF 2669 02:38:24,618 --> 02:38:26,087 INITIATIVES LOOKING AT IMPACTS 2670 02:38:26,087 --> 02:38:28,556 OF EARLY LIFE EVENTS ON LATER 2671 02:38:28,556 --> 02:38:30,324 CONSEQUENCES, BE THEY 2672 02:38:30,324 --> 02:38:32,827 ENVIRONMENTAL, EARLY OR GENETIC 2673 02:38:32,827 --> 02:38:33,761 DETERMINATIVE EVENTS, AND WILL 2674 02:38:33,761 --> 02:38:34,962 CONTINUE. SHARING INFORMATION 2675 02:38:34,962 --> 02:38:37,631 WITH ALL OF YOU IS PART OF THE 2676 02:38:37,631 --> 02:38:39,367 LEARNING PROCESS. I THINK SANJAY 2677 02:38:39,367 --> 02:38:40,935 WAS NEXT. 2678 02:38:40,935 --> 02:38:43,804 >> YAH, THANK YOU. THANK YOU 2679 02:38:43,804 --> 02:38:45,706 FOR THE OUTSTANDING 2680 02:38:45,706 --> 02:38:49,643 PRESENTATIONS. ONE OF THE AREAS 2681 02:38:49,643 --> 02:38:52,546 NIA IS INVESTING HEAVY IS THE 2682 02:38:52,546 --> 02:38:56,517 SOCIOLOGICAL BASIS OF THESE 2683 02:38:56,517 --> 02:38:58,419 DISEASES. WONDER WE KNOW THEY 2684 02:38:58,419 --> 02:39:02,623 ARE ACTIVE THROUGHOUT THE LIFE, 2685 02:39:02,623 --> 02:39:06,994 PERHAPS IN UTERO. WONDER IF 2686 02:39:06,994 --> 02:39:09,030 THERE IS RESEARCH AS RELATES TO 2687 02:39:09,030 --> 02:39:10,731 DOWN'S SYNDROME AND OTHER 2688 02:39:10,731 --> 02:39:12,166 RELATED DISORDERS. 2689 02:39:12,166 --> 02:39:14,001 >> SO THANKS FOR THAT 2690 02:39:14,001 --> 02:39:16,437 QUESTION. SOCIAL DETERMINANTS OF 2691 02:39:16,437 --> 02:39:17,571 HEALTH ARE DEFINITELY AN 2692 02:39:17,571 --> 02:39:19,273 INCREASING PART OF OUR EMPHASIS. 2693 02:39:19,273 --> 02:39:22,777 THERE IS NO QUESTION THAT IT 2694 02:39:22,777 --> 02:39:23,844 AFFECTS FETAL DEVELOPMENT AND 2695 02:39:23,844 --> 02:39:30,051 ALSO THE SUCCESS OF THE 2696 02:39:30,051 --> 02:39:30,818 PREGNA 2697 02:39:30,818 --> 02:39:33,587 PREGNANCY AND MATERNAL HEALTH 2698 02:39:33,587 --> 02:39:34,288 LONG-TERM. I WOULD SAY MOST OF 2699 02:39:34,288 --> 02:39:36,791 THE FOCUS HAS BEEN ON HOW THE 2700 02:39:36,791 --> 02:39:39,193 SOCIAL DETERMINANTS OF HEALTH 2701 02:39:39,193 --> 02:39:41,629 AFFECT CHILD DEVELOPMENT. WE 2702 02:39:41,629 --> 02:39:44,565 HAVE A BIG CHILDHOOD DEVELOPMENT 2703 02:39:44,565 --> 02:39:47,468 AND BEHAVIOR BRANCH WHICH TAKES 2704 02:39:47,468 --> 02:39:49,670 MOST UP THROUGH ADOLESCENCE BUT 2705 02:39:49,670 --> 02:39:55,810 AGAIN THEY HAVE TO HAND OVER TO 2706 02:39:55,810 --> 02:39:57,945 AN ADULT-ORIENTED INVESTIGATOR. 2707 02:39:57,945 --> 02:39:59,780 I THINK THERE WOULD BE 2708 02:39:59,780 --> 02:40:03,050 OPPORTUNITIES TO SHARE THAT DATA 2709 02:40:03,050 --> 02:40:07,121 OR EX CHANGE DATA. WE ARE 2710 02:40:07,121 --> 02:40:08,022 COLLECTING IT. 2711 02:40:08,022 --> 02:40:10,458 >> KAREN. 2712 02:40:10,458 --> 02:40:12,393 >> THANK YOU, DR. BIANCHI FOR 2713 02:40:12,393 --> 02:40:14,995 THE TALK. IT WAS LOEL. AS A 2714 02:40:14,995 --> 02:40:17,398 PROFESSOR OF PEDIATRICS IT 2715 02:40:17,398 --> 02:40:20,334 HELPED JUSTIFY MY ROLE ON BEING 2716 02:40:20,334 --> 02:40:21,802 HERE. MY QUESTION RELATES TO 2717 02:40:21,802 --> 02:40:23,671 YOUR DOWN'S SYNDROME MODEL 2718 02:40:23,671 --> 02:40:25,339 WITHIN YOUR MOUSE STRAIN. I 2719 02:40:25,339 --> 02:40:27,108 GUESS I'M SOMEWHAT UNFAMILIAR 2720 02:40:27,108 --> 02:40:30,177 WITH THAT. WE WORKED WITH A 2721 02:40:30,177 --> 02:40:33,514 PRODROY STRAIN OF ANIMALS. IT 2722 02:40:33,514 --> 02:40:40,121 WAS AN ANTIPLOID, BUT NOT 2723 02:40:40,121 --> 02:40:42,923 STABLE. ALL TYPES THAT WERE 2724 02:40:42,923 --> 02:40:46,327 PREDISPOSING TO SYNDROMES LIKE 2725 02:40:46,327 --> 02:40:47,795 DOWN'S WOULD BE. I'M CURIOUS, 2726 02:40:47,795 --> 02:40:48,996 THE MODEL YOU ARE USING AND 2727 02:40:48,996 --> 02:40:51,565 WITHIN YOUR DATA SETS, DOWN'S 2728 02:40:51,565 --> 02:40:55,569 SYNDROME IS REPRESENTED BY THE 2729 02:40:55,569 --> 02:40:58,839 TRISOME21 BUT ARE YOU HAVING ANY 2730 02:40:58,839 --> 02:41:05,813 OTHER ANTIPLOMES WITH A PRAGERIA 2731 02:41:05,813 --> 02:41:06,847 TYPE EFFECT? 2732 02:41:06,847 --> 02:41:08,048 >> NO, BUT THANK YOU FOR THE 2733 02:41:08,048 --> 02:41:10,017 QUESTION. WE HAVE OUR HANDS FULL 2734 02:41:10,017 --> 02:41:12,353 WITH THE FOUR MOUSE. HUMAN 2735 02:41:12,353 --> 02:41:14,121 CHROMOSOME 21 DOES NOT HAVE AN 2736 02:41:14,121 --> 02:41:16,524 EXACT EQUIVALENT IN MOUSE. IT IS 2737 02:41:16,524 --> 02:41:19,360 PART OF MULTIPLE CHROMOSOMES, 2738 02:41:19,360 --> 02:41:23,597 MAYBE MOUSE 16. TRISOMY OF MOUSE 2739 02:41:23,597 --> 02:41:24,765 CHROMOSOME 16 IS LETHAL SO 2740 02:41:24,765 --> 02:41:26,600 VARIOUS MODELS HAVE BEEN MADE 2741 02:41:26,600 --> 02:41:29,103 THAT INCORPORATE MOUSE 2742 02:41:29,103 --> 02:41:31,472 CHROMOSOME 17 AND 10. BUT I WILL 2743 02:41:31,472 --> 02:41:35,009 TELL YOU THAT I AM IN THE SAME 2744 02:41:35,009 --> 02:41:41,015 -- MY I INTRAMURAL LAB IS IN THE 2745 02:41:41,015 --> 02:41:44,218 SAME CENTER AS DR. FRANCIS'S 2746 02:41:44,218 --> 02:41:48,189 LAB. HE'S BEEN STUDYING PROGERIA 2747 02:41:48,189 --> 02:41:50,624 AND VARIOUS THERAPIES. WE ARE 2748 02:41:50,624 --> 02:41:55,229 INTERESTED IN MPLACENTAS OF MIC 2749 02:41:55,229 --> 02:41:59,800 AND THEIR MODELS, WHICH I THINK 2750 02:41:59,800 --> 02:42:00,834 THEY DEVELOPED IN THEIR VERSION 2751 02:42:00,834 --> 02:42:03,304 OF PROGERIA. IT IS SOMETHING WE 2752 02:42:03,304 --> 02:42:05,039 WOULD LIKE TO LOOK AT BECAUSE 2753 02:42:05,039 --> 02:42:06,874 THEY BASICALLY DON'T USE THE 2754 02:42:06,874 --> 02:42:08,709 PLACENTA. I'D BE CURIOUS TO KNOW 2755 02:42:08,709 --> 02:42:13,647 IS APPP HIGHLY OVER-EXPRESSED IN 2756 02:42:13,647 --> 02:42:14,949 PLACENTAS OF THOSE MICE. 2757 02:42:14,949 --> 02:42:17,518 >> ONE LAST CONCEPTUAL THING 2758 02:42:17,518 --> 02:42:19,787 TO CLOSE. IN SPACE OF PEDIATRIC 2759 02:42:19,787 --> 02:42:21,589 AND ADOLESCENT MEDICINE I THINK 2760 02:42:21,589 --> 02:42:24,491 A LOT OF PATHOLOGIES OR 2761 02:42:24,491 --> 02:42:26,193 HALLMARKS OF AGING WERE IGNORED 2762 02:42:26,193 --> 02:42:28,362 A LONG PERIOD OF TIME. IT WASN'T 2763 02:42:28,362 --> 02:42:30,698 THAT WE WERE LOOKING, ASSUMING 2764 02:42:30,698 --> 02:42:32,600 IT WAS SOMETHING OLD PEOPLE GOT. 2765 02:42:32,600 --> 02:42:34,668 BUT THE INVIGORATING OF AGING 2766 02:42:34,668 --> 02:42:37,905 FIELD, LOOKING NOW DO WE SEE 2767 02:42:37,905 --> 02:42:41,976 EVIDENCE OF SIN NESENSE IN YOUNG 2768 02:42:41,976 --> 02:42:43,978 INDIVIDUALS AMPLIFIED AS WELL, 2769 02:42:43,978 --> 02:42:46,747 WONDERFUL TALK. 2770 02:42:46,747 --> 02:42:51,185 >> THANK YOU. 2771 02:42:51,185 --> 02:42:55,222 >> HI. DR. BIANCHI, I WORK 2772 02:42:55,222 --> 02:42:56,991 WITH CHEROKEE NATION IN 2773 02:42:56,991 --> 02:42:58,826 NORTHEAST OKLAHOMA. WITH A LOT 2774 02:42:58,826 --> 02:43:02,062 OF NATIVE AMERICAN POPULATION. 2775 02:43:02,062 --> 02:43:08,402 MY QUESTION HAS NOT SO MUCH 2776 02:43:08,402 --> 02:43:10,871 AGING BUT AUTISM DISORDER WHICH 2777 02:43:10,871 --> 02:43:13,173 FALLS WITHIN YOUR PORTFOLIO. 2778 02:43:13,173 --> 02:43:16,477 WONDERING WHAT KIND OF EFFORTS 2779 02:43:16,477 --> 02:43:26,020 ARE BEING MEAT MADE N /* /* -- 2780 02:43:26,020 --> 02:43:29,723 MADE IN INDIAN COUNTRY. I HAVE 2781 02:43:29,723 --> 02:43:31,759 AN INTEREST IN THIS AREA. 2782 02:43:31,759 --> 02:43:34,662 >> YOU AND OUR NEW NIH 2783 02:43:34,662 --> 02:43:37,965 DIRECTOR, NOT SURE IF YOU KNEW 2784 02:43:37,965 --> 02:43:43,370 DR. MONICA, THE NEW DIRECTOR OF 2785 02:43:43,370 --> 02:43:45,239 NIH, HAS AN ADULT SON WITH 2786 02:43:45,239 --> 02:43:45,639 AUTISM. 2787 02:43:45,639 --> 02:43:47,241 >> HE JUST TURNED 30. 2788 02:43:47,241 --> 02:43:51,078 >> OH, HAPPY BIRTHDAY. HER 2789 02:43:51,078 --> 02:43:56,050 SON IS 27. THE INTERAGENCY 2790 02:43:56,050 --> 02:43:58,152 CONSORTIUM ON AUTISM RESEARCH IS 2791 02:43:58,152 --> 02:43:59,953 MEETING TODAY, SO I HEARD HER 2792 02:43:59,953 --> 02:44:07,795 SPEAKING ABOUT HER SON, BEN. WE 2793 02:44:07,795 --> 02:44:14,335 JOINTLY FUND THE AUTISM EXCEPT 2794 02:44:14,335 --> 02:44:16,437 CENTERS OF EXCELLENCE, A. C. E., 2795 02:44:16,437 --> 02:44:17,604 WITH NATIONAL INSTITUTES OF 2796 02:44:17,604 --> 02:44:19,306 HEALTH. OFF THE TOP OF MY HEAD I 2797 02:44:19,306 --> 02:44:21,041 CAN'T TELL YOU EXACTLY WHAT WE 2798 02:44:21,041 --> 02:44:22,409 ARE FUNDING IN INDIAN COUNTRY, 2799 02:44:22,409 --> 02:44:24,478 BUT IF YOU SEND ME AN EMAIL,LY 2800 02:44:24,478 --> 02:44:27,548 BE ABLE TO ANSWER YOU. 2801 02:44:27,548 --> 02:44:28,749 >> ABSOLUTELY. 2802 02:44:28,749 --> 02:44:30,217 >> YEAH. 2803 02:44:30,217 --> 02:44:34,221 >> I NOTICE THERE IS WORK 2804 02:44:34,221 --> 02:44:38,192 DONE WITH NAVAJO NATION. I'M NOT 2805 02:44:38,192 --> 02:44:39,293 FAMILY WITH ANYTHING IN FOUR, 2806 02:44:39,293 --> 02:44:41,295 FIVE OF BIGGEST TRIBES IN 2807 02:44:41,295 --> 02:44:43,163 OKLAHOMA. I CAN REACH OUT TO 2808 02:44:43,163 --> 02:44:43,731 YOUR LATER. 2809 02:44:43,731 --> 02:44:45,099 >> YEAH. 2810 02:44:45,099 --> 02:44:48,302 >> I WORK WITH THIS 2811 02:44:48,302 --> 02:44:50,904 COMMUNITY, I LIVE THERE. I KNOW 2812 02:44:50,904 --> 02:45:01,448 THERE ARE HARDLY ANY SERVICES. 2813 02:45:03,283 --> 02:45:04,585 WE JUST HEAR ABOUT PEOPLE AS A 2814 02:45:04,585 --> 02:45:05,319 CHILD AND CONCERNS ME. 2815 02:45:05,319 --> 02:45:06,987 >> I WANT TO T BE SPECIFIC TO 2816 02:45:06,987 --> 02:45:08,789 LET YOU KNOW EXACTLY -- 2817 02:45:08,789 --> 02:45:09,990 >> EVEN IF NOTHING'S BEEN 2818 02:45:09,990 --> 02:45:12,126 DONE -- I'M SURE THERE'S A LOT. 2819 02:45:12,126 --> 02:45:14,862 BUT WE CAN FIND WAYS TO WORK 2820 02:45:14,862 --> 02:45:16,263 TOGETHER TO BRING MORE RESEARCH 2821 02:45:16,263 --> 02:45:17,765 TO INDIAN COUNTRY. THAT IS THE 2822 02:45:17,765 --> 02:45:19,633 POINT I'M TRYING TO MAKE. 2823 02:45:19,633 --> 02:45:20,234 >> THANK YOU. 2824 02:45:20,234 --> 02:45:21,902 >> THANK YOU FOR YOUR 2825 02:45:21,902 --> 02:45:22,269 RECOMMENDATION. 2826 02:45:22,269 --> 02:45:24,405 >> CERTAINLY IN MATERNAL 2827 02:45:24,405 --> 02:45:26,507 HEALTH, YOU KNOW, WE ARE VERY 2828 02:45:26,507 --> 02:45:30,210 CONCERNED ABOUT INCREASED RISK 2829 02:45:30,210 --> 02:45:32,479 OF MATERNAL MORTALITY IN VARIOUS 2830 02:45:32,479 --> 02:45:33,714 TRIBAL NATIONS. WE ARE WORKING 2831 02:45:33,714 --> 02:45:36,817 ON THAT AS WELL. 2832 02:45:36,817 --> 02:45:40,120 >> THANK YOU SO MUCH. 2833 02:45:40,120 --> 02:45:41,355 >> MIRTA. 2834 02:45:41,355 --> 02:45:48,762 >> HI, DR. BIANCHI, THANK 2835 02:45:48,762 --> 02:45:52,199 YOU. THIS WAS AMAZING. I'M A 2836 02:45:52,199 --> 02:45:55,736 NON-SCIENTIST AND SIT ON THE 2837 02:45:55,736 --> 02:45:58,105 COUNCIL AND THE DIANE CONSORTIUM 2838 02:45:58,105 --> 02:46:03,243 NETWORK. PRIMARILY REPRESENTING 2839 02:46:03,243 --> 02:46:06,180 FAMILIES, ADAD FAMILIES. SO 2840 02:46:06,180 --> 02:46:07,681 MULTIPLE MEMBERS OF MY FAMILY 2841 02:46:07,681 --> 02:46:10,784 AND ALSO I HAVE BEEN A 2842 02:46:10,784 --> 02:46:15,556 CAREGIVER. I AM ABSOLUTELY JUST 2843 02:46:15,556 --> 02:46:16,390 AMAZED AT EVERYTHING YOU 2844 02:46:16,390 --> 02:46:20,093 PRESENTED. I THANK YOU FOR THAT 2845 02:46:20,093 --> 02:46:22,529 WORK. ESPECIALLY LOOKING AT -- 2846 02:46:22,529 --> 02:46:24,898 I'M IN SPECIAL EDUCATION, 2847 02:46:24,898 --> 02:46:25,999 DIRECTOR CURRENTLY OF SPECIAL 2848 02:46:25,999 --> 02:46:27,768 EDUCATION BUT I HAVE BEEN IN THE 2849 02:46:27,768 --> 02:46:36,276 FIELD SINCE I WAS 19 YEARS OLD. 2850 02:46:36,276 --> 02:46:38,946 SO SEE THE WORK DONE WITH DOWN'S 2851 02:46:38,946 --> 02:46:44,184 SYNDROME AND LOOKING AT ADAD, IT 2852 02:46:44,184 --> 02:46:45,085 IS A WONDERFUL THING TO SEE IT 2853 02:46:45,085 --> 02:46:46,887 IS HAPPENING. I HOPE A LOT MORE 2854 02:46:46,887 --> 02:46:49,156 WILL BE -- WE WILL LEARN MORE 2855 02:46:49,156 --> 02:46:55,229 FROM THAT. I ALSO WANTED TO -- 2856 02:46:55,229 --> 02:46:56,864 TO ME YOU SAID SOMETHING AROUND 2857 02:46:56,864 --> 02:46:58,565 -- YOU SAID MIGHT BE CRAZY BUT I 2858 02:46:58,565 --> 02:47:00,467 WILL TELL YOU WHAT, CRAZY IS 2859 02:47:00,467 --> 02:47:02,069 REALLY, REALLY GOOD. I AM SO 2860 02:47:02,069 --> 02:47:03,837 EXCITED TO SEE ALL THE WORK THAT 2861 02:47:03,837 --> 02:47:05,239 YOU'RE DOING WITH THE PLACENTA. 2862 02:47:05,239 --> 02:47:09,710 TO ME THAT ALL MAKES ABSOLUTE 2863 02:47:09,710 --> 02:47:12,145 SENSE. AGAIN, I'M NOT A 2864 02:47:12,145 --> 02:47:13,180 SCIENTIST BUT REALLY MAKES 2865 02:47:13,180 --> 02:47:15,215 SENSE. I HOPE MORE PEOPLE WILL 2866 02:47:15,215 --> 02:47:17,284 BE INTERESTED IN STUDYING THAT. 2867 02:47:17,284 --> 02:47:18,085 THANK YOU FOR YOUR PRESENTATION 2868 02:47:18,085 --> 02:47:19,152 AND ALL YOUR WORK. 2869 02:47:19,152 --> 02:47:22,089 >> THANK YOU, MARITZA FOR 2870 02:47:22,089 --> 02:47:27,794 YOUR COMMENTS, APPRECIATE IT. 2871 02:47:27,794 --> 02:47:30,597 >> THANKS. ONE MORE QUESTION. 2872 02:47:30,597 --> 02:47:31,865 >> THANK YOU FOR THE VERY 2873 02:47:31,865 --> 02:47:33,467 EXCITING TALK. ESPECIALLY 2874 02:47:33,467 --> 02:47:40,507 EXCITING ABOUT YOUR BIG COHORT 2875 02:47:40,507 --> 02:47:45,279 ON THIS DOWN'S SYNDROME. ALSO 2876 02:47:45,279 --> 02:47:48,282 ESPECIALLY ALZHEIMER'S BUT ITS 2877 02:47:48,282 --> 02:47:50,817 ROLE AND AFFECT ON EARLY ON 2878 02:47:50,817 --> 02:47:53,453 DESTINY SET OF THIS IS NOT WELL 2879 02:47:53,453 --> 02:47:54,955 STUDIED. BECAUSE OF THE SMALL 2880 02:47:54,955 --> 02:47:57,524 COHORT. WONDER WHETHER YOU HAVE 2881 02:47:57,524 --> 02:48:00,127 ANY INFORMATION ABOUT THE 2882 02:48:00,127 --> 02:48:03,797 DEGENERATIVE EFFECT IN THE BIG 2883 02:48:03,797 --> 02:48:04,998 DOWN'S SYNDROME COHORT. 2884 02:48:04,998 --> 02:48:06,333 >> THAT WOULD BE SOMETHING, 2885 02:48:06,333 --> 02:48:08,802 YOU COULD ASK THE QUESTIONS OF 2886 02:48:08,802 --> 02:48:11,772 THE DATA RESOURCE. YOU KNOW, I 2887 02:48:11,772 --> 02:48:13,507 PERSONALLY HAVING PLUMBED IT FOR 2888 02:48:13,507 --> 02:48:19,680 THAT PARTICULAR TYPE OF 2889 02:48:19,680 --> 02:48:19,980 QUESTION. 2890 02:48:19,980 --> 02:48:21,348 >> THAT WOULD BE GREAT. I 2891 02:48:21,348 --> 02:48:22,816 WILL CONTACT TO SEE IF I CAN DO 2892 02:48:22,816 --> 02:48:23,317 SOMETHING THERE. 2893 02:48:23,317 --> 02:48:26,219 >> YES. 2894 02:48:26,219 --> 02:48:30,891 >> THANK YOU. 2895 02:48:30,891 --> 02:48:32,059 >> ALL RIGHT. THANK YOU VERY 2896 02:48:32,059 --> 02:48:35,696 MUCH. DR. BIANCHI, AMAZING TALK. 2897 02:48:35,696 --> 02:48:38,165 THANK YOU FOR ANSWERING ALL THE 2898 02:48:38,165 --> 02:48:40,167 QUESTIONS FROM ALL OUR COUNCIL 2899 02:48:40,167 --> 02:48:41,902 MEMBERS. IT WAS INSPIRATIONAL 2900 02:48:41,902 --> 02:48:43,804 AND INFORMATIVE OF HOW MUCH 2901 02:48:43,804 --> 02:48:45,372 OVERLAP BETWEEN OUR INSTITUTES 2902 02:48:45,372 --> 02:48:49,776 AND WHAT MANY POSSIBILITIES FOR 2903 02:48:49,776 --> 02:48:52,946 FURTHER INTERACTIONS AND NEW 2904 02:48:52,946 --> 02:48:54,781 ARENAS FOR RESEARCH IN THAT 2905 02:48:54,781 --> 02:48:55,048 HORIZON. 2906 02:48:55,048 --> 02:48:55,649 >> GREAT. 2907 02:48:55,649 --> 02:48:58,185 >> THANKS, DIANA. WE CAN 2908 02:48:58,185 --> 02:48:59,152 FOLLOW UP TOMORROW MORNING. 2909 02:48:59,152 --> 02:49:00,220 >> WONDERFUL. THANK YOU FOR 2910 02:49:00,220 --> 02:49:01,588 INVITING ME. I WILL TRY TO 2911 02:49:01,588 --> 02:49:04,791 ANSWER SOME OF THE QUESTIONS IN 2912 02:49:04,791 --> 02:49:05,859 THE CHAT BOX TOO. 2913 02:49:05,859 --> 02:49:06,660 >> THANK YOU AGAIN. 2914 02:49:06,660 --> 02:49:07,894 >> THANK YOU. 2915 02:49:07,894 --> 02:49:08,495 2916 02:49:08,495 --> 02:49:11,098 >> ALL RIGHT. SO NEXT UP WE 2917 02:49:11,098 --> 02:49:14,001 HAVE ONE MORE SPEAKER, THEN WE 2918 02:49:14,001 --> 02:49:17,671 WILL BE HEARING FROM OUR 2919 02:49:17,671 --> 02:49:20,507 INTRAMURAL PROGRAM SO TURN OVER 2920 02:49:20,507 --> 02:49:23,744 TO OUR DIRECTOR OF DIVISION OF 2921 02:49:23,744 --> 02:49:27,414 NEUROSCIENCE TO INTRODUCE THE 2922 02:49:27,414 --> 02:49:28,682 NEXT SPEAKER. 2923 02:49:28,682 --> 02:49:33,487 >> THANK YOU. I'M REALLY 2924 02:49:33,487 --> 02:49:38,392 PLEASED TO INTRODUCE DR. RYAN, 2925 02:49:38,392 --> 02:49:40,661 THE SPEAKER FOR THE HIGHLIGHT 2926 02:49:40,661 --> 02:49:51,204 TODAY. HE IS A PROFESSOR AT THE 2927 02:49:51,938 --> 02:49:53,807 UNIVERSITY NORTH TEXAS IN FORTH 2928 02:49:53,807 --> 02:49:55,208 WORTH AND PRINCIPLE INVESTIGATOR 2929 02:49:55,208 --> 02:49:58,045 OF HEALTH AND BRAIN STUDY, 2930 02:49:58,045 --> 02:49:59,813 HEALTH DISPARITIES. WE WILL HEAR 2931 02:49:59,813 --> 02:50:01,648 ABOUT THAT TODAY. AS YOU KNOW, 2932 02:50:01,648 --> 02:50:06,920 THIS IS A VERY IMPORTANT, HIGHLY 2933 02:50:06,920 --> 02:50:09,723 COMPREHENSIVE STUDY OF 2934 02:50:09,723 --> 02:50:11,124 ALZHEIMER'S AMONG THREE LARGEST 2935 02:50:11,124 --> 02:50:13,060 RACIAL ETHNIC GROUPS IN THE U.S. 2936 02:50:13,060 --> 02:50:15,262 CONNECTED INCLUDING 2937 02:50:15,262 --> 02:50:16,363 AFRICAN-AMERICAN, HISPANIC, 2938 02:50:16,363 --> 02:50:17,831 NON-HISPANIC WHITES. WE WILL 2939 02:50:17,831 --> 02:50:21,902 HEAR A LOT MORE ABOUT THESE VERY 2940 02:50:21,902 --> 02:50:27,274 EXCITING PROJECT. BUT THE 2941 02:50:27,274 --> 02:50:29,910 PROJECT HAS MAIN FOCUS 2942 02:50:29,910 --> 02:50:31,812 UNDERSTANDING COURSE FACTORS 2943 02:50:31,812 --> 02:50:34,114 INCLUDING BIOLOGICAL, 2944 02:50:34,114 --> 02:50:36,983 ENVIRONMENTAL, BEHAVIORAL, HOW 2945 02:50:36,983 --> 02:50:38,518 THEY IMPACT ALZHEIMER'S DISEASE 2946 02:50:38,518 --> 02:50:40,887 IN LATE LIFE. DR. RYAN IS ALSO A 2947 02:50:40,887 --> 02:50:45,892 GLOBAL EXPERT ON THE USE OF 2948 02:50:45,892 --> 02:50:47,527 BLOOD-BASED BIO MARK ERS FOR 2949 02:50:47,527 --> 02:50:51,298 GENERATION OF PRECISION MEDICINE 2950 02:50:51,298 --> 02:50:53,600 APPROACHES AND STRATEGIES FOR 2951 02:50:53,600 --> 02:50:59,773 AD, PARKINSON'S, LOUIE BODY AND 2952 02:50:59,773 --> 02:51:00,907 PARKINSON'S. WITHOUT FURTHER 2953 02:51:00,907 --> 02:51:02,242 ADIEU, DO THE HONORS. THANK YOU 2954 02:51:02,242 --> 02:51:05,712 FOR ACCEPTING INVITATION. 2955 02:51:05,712 --> 02:51:10,317 >> THANK YOU. IT IS A 2956 02:51:10,317 --> 02:51:12,085 PLEASURE TO BE HERE AND REALLY 2957 02:51:12,085 --> 02:51:16,423 NICE TO SEE SO MANY FRIENDS ON 2958 02:51:16,423 --> 02:51:19,359 THIS ZOOM. BEFORE I DON'T WANT 2959 02:51:19,359 --> 02:51:21,394 TO FOR GET SINCE THE DETECTOR 2960 02:51:21,394 --> 02:51:27,334 SPEAK ABOUT ABCDS, IS DR. UDON, 2961 02:51:27,334 --> 02:51:30,537 THE DATA, APO4 IS THERE. THERE 2962 02:51:30,537 --> 02:51:31,938 ARE INVESTIGATORS AND I'M HAPPY 2963 02:51:31,938 --> 02:51:34,007 TO CONNECT YOU CAN SOME PEOPLE. 2964 02:51:34,007 --> 02:51:36,176 I ACTUALLY AM THE DIRECTOR OF 2965 02:51:36,176 --> 02:51:42,182 THE MIX 4 AND 3 OF THIS. ONE OF 2966 02:51:42,182 --> 02:51:45,819 THE NICE THINGS IS THE OMIX OF 2967 02:51:45,819 --> 02:51:49,956 THESE ARE OVERLAPPED. BECAUSE WE 2968 02:51:49,956 --> 02:51:54,060 ARE 30 AND ABOVE, HABSHD NOT 2969 02:51:54,060 --> 02:51:55,796 ONLY FROM MULTI -ETHNIC BUT 2970 02:51:55,796 --> 02:51:59,366 YOUNGER SIDE WE HAVE BUILT-IN 2971 02:51:59,366 --> 02:52:01,101 CROSS COLLABORATION CAPACITY 2972 02:52:01,101 --> 02:52:05,172 FROM A NOMICS ASPECTS AND COVER 2973 02:52:05,172 --> 02:52:08,909 IMAGING WORK. SO JUST BEFORE I 2974 02:52:08,909 --> 02:52:11,411 FORGET -- WELL I LOVE THE STUDY 2975 02:52:11,411 --> 02:52:13,580 AND HAVE BEEN INVOLVED WITH IT 2976 02:52:13,580 --> 02:52:16,383 SINCE THE INCEPTION. I WILL TALK 2977 02:52:16,383 --> 02:52:19,753 ABOUT HABSHD. IT IS NOT JUST 2978 02:52:19,753 --> 02:52:22,322 WHAT WE HAVE DONE. WHAT CERISE 2979 02:52:22,322 --> 02:52:25,759 AND DEMALI HAVE ASKED HOW WE 2980 02:52:25,759 --> 02:52:27,794 COVER, HOW WE HAVE DONE IT. THE 2981 02:52:27,794 --> 02:52:29,796 STRUCTURE IS APPARENTLY A BIT 2982 02:52:29,796 --> 02:52:31,798 DIFFERENT FROM WHAT SOME OTHER 2983 02:52:31,798 --> 02:52:33,233 RESEARCH GROUPS AND STRUCTURES 2984 02:52:33,233 --> 02:52:41,374 ARE PULLED TOGETHER AND 2985 02:52:41,374 --> 02:52:43,343 FUNCTION. NEXT SLIDE SO BRIEFLY 2986 02:52:43,343 --> 02:52:45,645 IN TERMS OF STRUCTURE, THIS IS 2987 02:52:45,645 --> 02:52:46,847 SIMILAR TO ANY LARGE-SCALE 2988 02:52:46,847 --> 02:52:48,882 PROGRAM WHERE WE HAVE AN 2989 02:52:48,882 --> 02:52:51,718 ADMINISTER CORE WHERE I RUN THE 2990 02:52:51,718 --> 02:52:54,921 MPI TEAM AND HELPS WITH THE 2991 02:52:54,921 --> 02:52:57,657 ADMINISTER COURSE AND IMAGING 2992 02:52:57,657 --> 02:53:02,495 CORE IS RUN BY DR. CORE AND 2993 02:53:02,495 --> 02:53:07,567 BRADLY AND LEAD WITH JOHNSON AND 2994 02:53:07,567 --> 02:53:10,670 MAPSTONE. THE OUTREACH, DR. 2995 02:53:10,670 --> 02:53:13,073 JOHNSON, MILKY AND HILL, RAMON 2996 02:53:13,073 --> 02:53:17,344 AND PALMER. THE DEVELOPMENT LIKE 2997 02:53:17,344 --> 02:53:20,580 OQUONKO AND DR. VERMIT AND THREE 2998 02:53:20,580 --> 02:53:24,150 PROJECTS. NEXT SLIDE, PLEASE. SO 2999 02:53:24,150 --> 02:53:27,354 THIS SLIDE REALLY, TO ME, 3000 02:53:27,354 --> 02:53:29,122 ENCOMPASSES THE NATURE OF THIS 3001 02:53:29,122 --> 02:53:32,659 ENTIRE PROGRAM. AS YOU ALL KNOW, 3002 02:53:32,659 --> 02:53:34,794 U19s ARE ONE LARGE PROGRAM. NOT 3003 02:53:34,794 --> 02:53:41,301 THREE SEPARATE PROJECTS LIKE A 3004 02:53:41,301 --> 02:53:48,808 PBG. PROJECT ONE IS DESIGNED TO 3005 02:53:48,808 --> 02:53:50,510 LOOK AT AM LLOYD TOWEL AND 3006 02:53:50,510 --> 02:53:53,179 BIO MARKERS. NOT JUST TO LOOK AT 3007 02:53:53,179 --> 02:53:59,119 BRAIN IMAGING, HOWEVER. WE ARE 3008 02:53:59,119 --> 02:54:05,625 DOING AMALOYID BUT ALSO ET 3009 02:54:05,625 --> 02:54:07,227 CETERA. THE WAY WE ARE LOOKING 3010 02:54:07,227 --> 02:54:15,302 IS VERY MULTI FACTORIAL AND 3011 02:54:15,302 --> 02:54:18,571 STRUCTURAL MODELLING TO BUILD 3012 02:54:18,571 --> 02:54:21,308 CON TRUKT OF AMYLOID BROADER 3013 02:54:21,308 --> 02:54:25,145 THAN CSF OR BRAIN. WE HAVE 3014 02:54:25,145 --> 02:54:27,480 LAUNCHED THE LUMBER PUNCTURE 3015 02:54:27,480 --> 02:54:29,516 STUDY SO WE HAVE STARTED IN THAT 3016 02:54:29,516 --> 02:54:31,952 PROGRAM. PROJECT TWO, PART WE 3017 02:54:31,952 --> 02:54:37,390 PROPOSE AN ATMV VASCULAR, 3018 02:54:37,390 --> 02:54:39,659 METABOLIC AND INFLAME TOIR. SO 3019 02:54:39,659 --> 02:54:41,928 WE ARE LOOKING AT THOSE FACTORS. 3020 02:54:41,928 --> 02:54:43,997 HOW DO THEY RELATE TO AND IMPACT 3021 02:54:43,997 --> 02:54:49,869 THE AMALOID REGENERATION IN 3022 02:54:49,869 --> 02:54:52,772 RECIPROCAL MATTER AND EARLY ON? 3023 02:54:52,772 --> 02:54:55,075 OUR HYPOTHESIS ISN'T THAT IT IS 3024 02:54:55,075 --> 02:54:59,312 THE PRESENCE BUT WHEN THEY 3025 02:54:59,312 --> 02:55:01,147 DEVELOP AND HOW THEY DEVELOP 3026 02:55:01,147 --> 02:55:03,850 OVER TIME. WE HAVE DATA COMING 3027 02:55:03,850 --> 02:55:07,120 OUT SHOWING THE DIFFERENT SUB 3028 02:55:07,120 --> 02:55:09,990 TYPES OF TOW BASED ON THE PET 3029 02:55:09,990 --> 02:55:16,463 SCANS. THESE SUB TYPES OF TOW 3030 02:55:16,463 --> 02:55:18,298 VERY AND CO MORBIDITIES IMPACT 3031 02:55:18,298 --> 02:55:20,233 THESE THINGS. WE NOW HAVE VERY 3032 02:55:20,233 --> 02:55:24,270 CLEAR DATA SAYING THE FRAMEWORK 3033 02:55:24,270 --> 02:55:25,972 VARIES SIGNIFICANTLY BETWEEN 3034 02:55:25,972 --> 02:55:28,608 GROUPS AND THAT VASCULAR 3035 02:55:28,608 --> 02:55:29,809 METABOLIC AND INFLAMMATORY 3036 02:55:29,809 --> 02:55:35,181 FACTORS HAVE AN IMPACT ON THESE 3037 02:55:35,181 --> 02:55:41,421 MAR 3038 02:55:41,421 --> 02:55:43,056 MARKERS. IN THE MIDDLE I DON'T 3039 02:55:43,056 --> 02:55:44,457 BELIEVE YOU CAN STUDY THE 3040 02:55:44,457 --> 02:55:46,926 ABSENCE IN SOCIAL OWE CULTURAL. 3041 02:55:46,926 --> 02:55:49,262 DOING SO IS BLINDERS AND MISSING 3042 02:55:49,262 --> 02:55:51,731 IMPORTANT COMPONENTS. EVERYTHING 3043 02:55:51,731 --> 02:55:58,905 WE DO IS WITHIN A SOCIOCULTURAL 3044 02:55:58,905 --> 02:56:01,141 CONTRACT. SO WITHIN THE 3045 02:56:01,141 --> 02:56:04,010 MULTI AND FULL-SCALE WE ARE 3046 02:56:04,010 --> 02:56:05,445 CAPTURING DATA AROUND THESE 3047 02:56:05,445 --> 02:56:08,148 BEHAVIORAL FACTORS. MANY KNOW 3048 02:56:08,148 --> 02:56:10,950 ABOUT AREA DEPRIVATION INDEX. WE 3049 02:56:10,950 --> 02:56:12,118 ARE CAPTURING THAT NOT ONLY 3050 02:56:12,118 --> 02:56:14,454 WHERE CURRENT BUT ACROSS ENTIRE 3051 02:56:14,454 --> 02:56:16,156 LIFE SPAN IN UNITED STATES AND 3052 02:56:16,156 --> 02:56:17,557 MEXICO, SO WE CAN LOOK AT CHANGE 3053 02:56:17,557 --> 02:56:20,493 OVER TIME. IN MEXICO THERE IS 3054 02:56:20,493 --> 02:56:21,728 INDEX OF MARGINIALIZATION. WE 3055 02:56:21,728 --> 02:56:26,366 ARE CAPTURING PERCEIVED RACISM. 3056 02:56:26,366 --> 02:56:28,468 DO YOU HAVE INSURANCE. BROAD 3057 02:56:28,468 --> 02:56:31,371 VARIETY OF COMPONENTS. NEXT 3058 02:56:31,371 --> 02:56:32,439 SLIDE, PLEASE. 3059 02:56:32,439 --> 02:56:36,242 SO ONE OF THE QUESTIONS THAT 3060 02:56:36,242 --> 02:56:40,346 I GET IS YOU ARE IN TEXAS. WHY 3061 02:56:40,346 --> 02:56:43,516 IS WHERE YOU ARE A GOOD PLACE TO 3062 02:56:43,516 --> 02:56:46,019 DO THIS SORT OF WORK? WELL, 3063 02:56:46,019 --> 02:56:47,587 FIRST AND FOREMOST I HAVE BEEN 3064 02:56:47,587 --> 02:56:49,155 DOING HEALTH DISPARITIES 3065 02:56:49,155 --> 02:56:50,523 RESEARCH OVER TWO DECADES SO 3066 02:56:50,523 --> 02:56:53,093 THIS IS WHAT I HAVE BEEN DOING 3067 02:56:53,093 --> 02:56:57,464 FOR MY ENTIRE CAREER LONG BEFORE 3068 02:56:57,464 --> 02:56:59,799 BLOOD-BASE BIOMARK ERS. IT'S 3069 02:56:59,799 --> 02:57:01,234 ALWAYS BEEN A FOCUSED RESEARCH 3070 02:57:01,234 --> 02:57:02,769 SO WE CONTINUE TO GROW OVER 3071 02:57:02,769 --> 02:57:07,040 TIME. WHY DFW? DALLAS/FORT WORTH 3072 02:57:07,040 --> 02:57:09,476 IS 7TH LARGEST METROPOLITAN AREA 3073 02:57:09,476 --> 02:57:13,880 IN UNITED STATES WITH AROUND 8 3074 02:57:13,880 --> 02:57:14,814 MILLION, SOON TO BE 9 MILLION. 3075 02:57:14,814 --> 02:57:17,851 WHERE THE UNITED STATES WILL BE 3076 02:57:17,851 --> 02:57:20,487 BY 2040, 2045 IN TERMS OF RACE 3077 02:57:20,487 --> 02:57:22,522 AND ETHNICITY, WE ALREADY ARE. 3078 02:57:22,522 --> 02:57:24,824 THIS IS WHY WE MOVED HERE IN THE 3079 02:57:24,824 --> 02:57:27,127 FIRST PLACE. DALLAS/FORT WORTH 3080 02:57:27,127 --> 02:57:28,795 IS A MICROCOSM WHERE THE UNITED 3081 02:57:28,795 --> 02:57:31,131 STATES WILL BE IN THE NEXT 3082 02:57:31,131 --> 02:57:31,931 SEVERAL DECADES WITH REGARD TO 3083 02:57:31,931 --> 02:57:34,767 RACE AND ETHNICITY. IT IS AN 3084 02:57:34,767 --> 02:57:36,336 IDEAL LOCATION TO CONDUCT THIS 3085 02:57:36,336 --> 02:57:41,174 SORT OF WORK. NEXT SLIDE, 3086 02:57:41,174 --> 02:57:42,976 PLEASE. SO WHERE ARE WE? ONE OF 3087 02:57:42,976 --> 02:57:45,211 THE THINGS THAT WE HAVE DONE 3088 02:57:45,211 --> 02:57:49,816 WITH DEMALI AND CERISE IS WE 3089 02:57:49,816 --> 02:57:52,652 ALWAYS TRY TO PROVIDE REGULAR 3090 02:57:52,652 --> 02:57:54,587 UPDATES TO OUR PROGRESS. ONE OF 3091 02:57:54,587 --> 02:57:56,589 THE THINGS BECAUSE OF THE M 3092 02:57:56,589 --> 02:57:59,792 ISES, WE ARE ALMOST NEVER BEHIND 3093 02:57:59,792 --> 02:58:01,661 SCHEDULE. WE ARE ALMOST ALWAYS 3094 02:58:01,661 --> 02:58:04,430 AHEAD OF SCHEDULE. FOR EXAMPLE, 3095 02:58:04,430 --> 02:58:05,865 ONE QUARTER THROUGH THE YEAR, 3096 02:58:05,865 --> 02:58:09,102 OUR MILESTONE FOR THE YEAR IS 3097 02:58:09,102 --> 02:58:10,303 1400 PARTICIPANTS. US AS A GROUP 3098 02:58:10,303 --> 02:58:12,705 WE SET OUR MILESTONE AND GOALS. 3099 02:58:12,705 --> 02:58:15,475 THE MILESTONE IS WHAT WE MUST 3100 02:58:15,475 --> 02:58:17,343 HIT AND GOAL IS WHERE WE WANT. 3101 02:58:17,343 --> 02:58:21,614 THE MILESTONE IN OUR NOA IS 3102 02:58:21,614 --> 02:58:22,916 1,400 PARTICIPANTS. THAT IS 3103 02:58:22,916 --> 02:58:25,652 TIMES FOUR OR FIVE VISITS SO WE 3104 02:58:25,652 --> 02:58:27,787 DO BETWEEN 5,000 AND 10,000 3105 02:58:27,787 --> 02:58:29,222 RESEARCH VISITS A YEAR. AT 20% 3106 02:58:29,222 --> 02:58:33,092 OF YEAR WE ARE ALREADY AT 30% OF 3107 02:58:33,092 --> 02:58:35,395 OVER MILESTONE WITH REGARD TO 3108 02:58:35,395 --> 02:58:36,763 PARTICIPANT RECRUITMENT AND ON 3109 02:58:36,763 --> 02:58:38,531 TARGET FOR OUR GOAL. BASED ON 3110 02:58:38,531 --> 02:58:41,201 WHERE WE ARE NOW WE ANTICIPATE 3111 02:58:41,201 --> 02:58:43,803 BEING 1600-PLUS PARTICIPANTS. IN 3112 02:58:43,803 --> 02:58:47,006 THAT MANNER WE ARE ALSO -- OUR 3113 02:58:47,006 --> 02:58:50,076 MILESTONE FOR PET SCANS IS ONE 3114 02:58:50,076 --> 02:58:51,077 EXPLICITLY LISTED. AS SUCH WE 3115 02:58:51,077 --> 02:58:55,014 ARE AHEAD OF SCHEDULE THERE. ON 3116 02:58:55,014 --> 02:58:56,749 RIGHT WHAT I HAVE TRIED TO 3117 02:58:56,749 --> 02:58:58,651 PROVIDE IS A BRIEF SNAPSHOT. 3118 02:58:58,651 --> 02:59:02,755 WHERE ARE WE? WHAT IS THIS DATA? 3119 02:59:02,755 --> 02:59:06,459 WHAT IS GOING ON, HOW IS THIS 3120 02:59:06,459 --> 02:59:08,161 HELPING? SO IN THE U19 WE HAVE 3121 02:59:08,161 --> 02:59:16,569 NOW IN A LITTLE OVER A YEAR WE 3122 02:59:16,569 --> 02:59:21,507 HAVE SEEN 2,142. SINCE INCEPTION 3123 02:59:21,507 --> 02:59:25,311 OVER 4,000. ALL DATA IS PUBLICLY 3124 02:59:25,311 --> 02:59:27,981 AVAILABLE. WE HAVE NOW CONNECTED 3125 02:59:27,981 --> 02:59:33,586 OVER 3,500AMYLOID PET SCANS, 3126 02:59:33,586 --> 02:59:36,723 BROKEN DOWN BETWEEN RACE AND 3127 02:59:36,723 --> 02:59:37,557 ETHNICITY. SOMETHING QUITE 3128 02:59:37,557 --> 02:59:39,459 HONESTLY IS WHAT WE WERE TOLD WE 3129 02:59:39,459 --> 02:59:40,994 COULDN'T DO. WE WERE TOLD YOU 3130 02:59:40,994 --> 02:59:43,529 CAN'T RECRUIT BLACKS AND 3131 02:59:43,529 --> 02:59:47,800 HISPANICS, THEN CAN'T DO MRIs OR 3132 02:59:47,800 --> 02:59:49,469 PETS. IN FACT, WE HAVE HAD HIGH 3133 02:59:49,469 --> 03:00:00,013 SUCCESS RATES. OVER 2100 PET TOW 3134 03:00:04,217 --> 03:00:07,020 SCANS. THIS IS THE LARGEST 3135 03:00:07,020 --> 03:00:09,822 COLLECTION OF AMAYLOID AND TOW 3136 03:00:09,822 --> 03:00:13,660 SCANS IN HISTORY AND ALL 3137 03:00:13,660 --> 03:00:20,566 PUBLICLY AVAILABLE. WE ARE 3138 03:00:20,566 --> 03:00:26,372 SUPPOSED TO DEPOSIT WHOLE 3139 03:00:26,372 --> 03:00:28,941 SEQUENCING IN 23 AND BEFORE THE 3140 03:00:28,941 --> 03:00:32,578 END OF 24 AND ANTICIPATE ANOTHER 3141 03:00:32,578 --> 03:00:36,716 1500 IN DATABASE AND DEPOSITING 3142 03:00:36,716 --> 03:00:43,890 GIWAS, ANCESTRY AND ONE THE 3143 03:00:43,890 --> 03:00:49,028 METHY LATION. SO INCREASING THE 3144 03:00:49,028 --> 03:00:50,496 THIS AND BASH IS SPEAKING TO 3145 03:00:50,496 --> 03:00:51,898 INCREASE AWARENESS OF WHAT WE 3146 03:00:51,898 --> 03:00:53,766 ARE DOING SO PEOPLE KNOW WHAT IS 3147 03:00:53,766 --> 03:00:55,234 THERE, WHAT IS AVAILABLE BECAUSE 3148 03:00:55,234 --> 03:01:00,740 ALL THIS DATA CAN THEN BE -- THE 3149 03:01:00,740 --> 03:01:03,776 PHENOTICAL DATA FOR STUDIES. IN 3150 03:01:03,776 --> 03:01:05,912 THE LAST 18 MONTHS WE PROVIDE 3151 03:01:05,912 --> 03:01:10,149 OVER 300 DATABASES AND LINKED TO 3152 03:01:10,149 --> 03:01:13,386 ABCS AND CLEAR AD, RECENTLY 3153 03:01:13,386 --> 03:01:16,089 FUNDED, I SERVE AS CHAIR OF 3154 03:01:16,089 --> 03:01:17,957 THEIR ADVISORY COMMITTEE SO 3155 03:01:17,957 --> 03:01:21,561 MAKING THE DATA AVAILABLE. WE 3156 03:01:21,561 --> 03:01:23,963 COLLABORATED WITH ADBYCAP, 3157 03:01:23,963 --> 03:01:34,507 NUMEROUS OTHER PROJECTS. THE 3158 03:01:38,845 --> 03:01:44,183 REPOSITORY IS ENORMOUS. CLOSE TO 3159 03:01:44,183 --> 03:01:45,618 5,000ALOQUATS. WE DO BUFF FI 3160 03:01:45,618 --> 03:01:48,788 CODE, SERUM, PLASMA. WE HAVE A 3161 03:01:48,788 --> 03:01:56,929 GOP1 TUBE SPECIFICALLY FOR 3162 03:01:56,929 --> 03:01:59,332 GOP1GLUCOGON AND INSULIN. WE ARE 3163 03:01:59,332 --> 03:02:01,567 ADDING PATCH GENE TUBES SO WILL 3164 03:02:01,567 --> 03:02:03,069 BE HAVING THAT AVAILABLE AS WELL 3165 03:02:03,069 --> 03:02:05,238 BECAUSE WE ARE STARTING 3166 03:02:05,238 --> 03:02:07,540 TRANSCRIPT. NEXT SLIDE, PLEASE. 3167 03:02:07,540 --> 03:02:10,343 SO HOW -- ONE OF THE QUESTIONS 3168 03:02:10,343 --> 03:02:12,612 WE GET OFTENTIMES IS HOW IS THIS 3169 03:02:12,612 --> 03:02:14,247 POSSIBLE? ALL PARTICIPANTS ARE 3170 03:02:14,247 --> 03:02:16,315 IN A SINGLE SITE. THAT IS WHAT I 3171 03:02:16,315 --> 03:02:17,984 DIDN'T MENTION. THERE ARE AROUND 3172 03:02:17,984 --> 03:02:19,819 17 SITES AFFILIATED WITH THE 3173 03:02:19,819 --> 03:02:23,623 STUDY BUT ALL PARTICIPANTS HELP 3174 03:02:23,623 --> 03:02:26,192 IN PLACE. SO THIS ENTIRE 3175 03:02:26,192 --> 03:02:27,627 INFRASTRUCTURE WAS BUILT OVER 3176 03:02:27,627 --> 03:02:30,963 TIME SPECIFICALLY TO MEET THIS 3177 03:02:30,963 --> 03:02:32,832 STUDIES NEEDS FOR SCALABILITY. 3178 03:02:32,832 --> 03:02:34,667 SO, FOR EXAMPLE, RIGHT NOW THE 3179 03:02:34,667 --> 03:02:38,938 FLOOR I'M ON WITH MY OFFICE IS A 3180 03:02:38,938 --> 03:02:40,072 20,000 SQUARE FOOT CLINICAL 3181 03:02:40,072 --> 03:02:42,842 FLOOR IN THE CLINICAL BUILDING. 3182 03:02:42,842 --> 03:02:44,577 THE REASON IS THE COMMUNITY CAN 3183 03:02:44,577 --> 03:02:46,579 DRIVE UP AS THOUGH THEY ARE 3184 03:02:46,579 --> 03:02:48,981 SEEING THEIR DOCS. IT IS EASY 3185 03:02:48,981 --> 03:02:51,951 YER TO GET TO, OVERHANG. WE ARE 3186 03:02:51,951 --> 03:02:55,421 IN THE PROCESS OF CAPTURING 3187 03:02:55,421 --> 03:02:57,256 ANOTHER 10,000 SQUARE FOOT RIGHT 3188 03:02:57,256 --> 03:02:59,792 ABOVE WHERE I'M AT NOW. WE HAVE 3189 03:02:59,792 --> 03:03:01,761 ALSO BUILT OUR OWN CUSTOM 3190 03:03:01,761 --> 03:03:03,463 SYSTEM, ALL THE WAY FROM 3191 03:03:03,463 --> 03:03:04,497 GROUND-UP BECAUSE AT TIME WHEN 3192 03:03:04,497 --> 03:03:07,066 WE STARTED THERE WAS NOTHING 3193 03:03:07,066 --> 03:03:08,034 COMPREHENSIVE ENOUGH FOR OUR 3194 03:03:08,034 --> 03:03:10,603 NEEDS. SO WE HAVE A CUSTOM 3195 03:03:10,603 --> 03:03:14,407 SCHEDULING SYSTEM, ELECTRONIC 3196 03:03:14,407 --> 03:03:15,675 DATABASE SYSTEM, LYMPH SYSTEM 3197 03:03:15,675 --> 03:03:19,545 THAT ARE 100% INTERCONNECTED. 3198 03:03:19,545 --> 03:03:21,747 FOR EXAMPLE WHEN SOMEONE SHOWS 3199 03:03:21,747 --> 03:03:25,685 UP, CHECKS IN AT THE FRONT DESK, 3200 03:03:25,685 --> 03:03:29,288 WHEN WE CHECK BAG WITH BLOOD 3201 03:03:29,288 --> 03:03:30,556 TUBES BEFORE PHLEBOTOMY, THEY 3202 03:03:30,556 --> 03:03:33,292 ARE NOT ONLY IN NEC FOR THE 3203 03:03:33,292 --> 03:03:35,795 ASSISTANT BUT IN THE LIMBS FOR 3204 03:03:35,795 --> 03:03:37,029 LABS EXPECTING BLOODS TO COME 3205 03:03:37,029 --> 03:03:39,732 OVER FOR PROCESSING. WE HAVE A 3206 03:03:39,732 --> 03:03:42,401 FULLY DEDICATED IMAGING CENTER. 3207 03:03:42,401 --> 03:03:44,237 THIS IS SOMETHING THAT WAS 3208 03:03:44,237 --> 03:03:45,538 REQUIRED. THERE IS NO WAY WE 3209 03:03:45,538 --> 03:03:47,340 COULD HAVE POSSIBLY DONE THIS IN 3210 03:03:47,340 --> 03:03:51,177 THE ABSENCE SO WE HAVE A FULLY 3211 03:03:51,177 --> 03:03:57,149 DEDICATED TO STATE-OF-THE-ART 3T 3212 03:03:57,149 --> 03:04:00,987 MRI, SIEMENS AND P2 SO NEVER A 3213 03:04:00,987 --> 03:04:04,090 BILLABLE PATIENT SCENE. IT IS 3214 03:04:04,090 --> 03:04:06,492 100% RESEARCH DEDICATED. WE CAN 3215 03:04:06,492 --> 03:04:15,468 DO OVER -- CLOSE TO CAPACITY OF 3216 03:04:15,468 --> 03:04:19,472 5,000 PER YEAR PET SCANS AND 3217 03:04:19,472 --> 03:04:21,140 5,000MRIs. ONE WENT OVER TO 3218 03:04:21,140 --> 03:04:22,408 OVERLAP THERE BUT NO OTHER 3219 03:04:22,408 --> 03:04:23,543 COMPANY WAS WILLING TO PROVIDE 3220 03:04:23,543 --> 03:04:27,547 TRACE ERS. THEY ALL TOLD US NO, 3221 03:04:27,547 --> 03:04:28,881 GE AND EVERYONE TOLD US NO 3222 03:04:28,881 --> 03:04:30,349 BECAUSE OF THE THROUGH-PUT 3223 03:04:30,349 --> 03:04:33,819 CAPACITY AND WE WERE SEEING 3224 03:04:33,819 --> 03:04:43,796 ANYWHERE BETWEEN 100 TO 3225 03:04:43,796 --> 03:04:45,331 150AMYLOIDS AND 50 TOW. WORKING 3226 03:04:45,331 --> 03:04:47,433 WITH SEW FI WE WERE ABLE TO MAKE 3227 03:04:47,433 --> 03:04:52,171 IT WORK. NOW RUN AROUND 200 PET 3228 03:04:52,171 --> 03:04:55,775 SCANS A MONTH, ON AVERAGE. IN 3229 03:04:55,775 --> 03:05:01,614 TERMS OF THEO MIX, THE REASON 3230 03:05:01,614 --> 03:05:04,083 KEEP UP IS UPDATED. IT IS NOT BY 3231 03:05:04,083 --> 03:05:06,285 HAND. WE HAVE HAMILTON EASY 3232 03:05:06,285 --> 03:05:11,290 BLOOD THAT PROCESS ALAQUOT INTO 3233 03:05:11,290 --> 03:05:13,993 EXACT NUMBERS. IF WE SAY THERE 3234 03:05:13,993 --> 03:05:17,296 ARE 250 MICRO LITERS THERE 3235 03:05:17,296 --> 03:05:19,565 ACTUALLY IS. NEXT SLIDE. THISS 3236 03:05:19,565 --> 03:05:23,502 IN MY OPINION, PROBABLY THE 3237 03:05:23,502 --> 03:05:29,508 SECRET TO OUR SUCCESS. MANY MY 3238 03:05:29,508 --> 03:05:30,876 EXPERIENCE GREAT SCIENTISTS 3239 03:05:30,876 --> 03:05:33,012 DON'T NECESSARILY MAKE GREAT 3240 03:05:33,012 --> 03:05:35,014 MANAGERS. WE HAVE BUILT THE TEAM 3241 03:05:35,014 --> 03:05:36,716 STRUCTURE IN A MANNER THAT, ONE, 3242 03:05:36,716 --> 03:05:39,452 IS VERY TRANSPARENT. WE HAVE 3243 03:05:39,452 --> 03:05:42,154 WEEKLY OR BIWEEKLY MEETINGS, 3244 03:05:42,154 --> 03:05:43,322 MONTHLY FOR SOME. EVERYTHING WE 3245 03:05:43,322 --> 03:05:46,726 HAVE DONE WAS BUILT FOR 3246 03:05:46,726 --> 03:05:49,462 SCALABILITY WHY IS WHY WE 3247 03:05:49,462 --> 03:05:52,465 BROUGHT OUR OWN EDC. RED CAP 3248 03:05:52,465 --> 03:05:53,933 COULDN'T MEET OUR CAPACITY BUT 3249 03:05:53,933 --> 03:05:55,201 WOULDN'T INTEGRATE WITH THE 3250 03:05:55,201 --> 03:05:57,803 OTHER SYSTEMS. WE ALSO -- I GET 3251 03:05:57,803 --> 03:05:59,372 A WEEKLY REPORT. I KNOW WHERE 3252 03:05:59,372 --> 03:06:00,706 EVERYTHING IS, HOW MANY PHONE 3253 03:06:00,706 --> 03:06:02,441 CALLS ARE DONE EVERY WEEK OR 3254 03:06:02,441 --> 03:06:05,578 PARTICIPANTS ARE SEEN EVERY 3255 03:06:05,578 --> 03:06:07,146 WEEK. NOT FOR MICROMANAGEMENT 3256 03:06:07,146 --> 03:06:08,714 BUT SO WE CAN SHARE THE 3257 03:06:08,714 --> 03:06:09,849 INFORMATION, HAVE RAPID 3258 03:06:09,849 --> 03:06:11,283 COMMUNICATION AND MONITORING 3259 03:06:11,283 --> 03:06:14,854 WHICH ALLOWS FOR ADAPTABILITY 3260 03:06:14,854 --> 03:06:19,025 AND FLEXIBILITY. WE WILL BUILD 3261 03:06:19,025 --> 03:06:20,893 IN NOT-SEEN PARTICIPANTS SO WHEN 3262 03:06:20,893 --> 03:06:22,728 WE HAVE TO DO -- SOMEONE BROUGHT 3263 03:06:22,728 --> 03:06:26,599 TO ONE OF OUR MEETINGS DR. RYAN 3264 03:06:26,599 --> 03:06:28,267 DON'T THINK YOU'D WANT TO HEAR 3265 03:06:28,267 --> 03:06:30,236 THIS BUT WE CAN'T SEE 3266 03:06:30,236 --> 03:06:31,737 PARTICIPANTS ON SO SO OF A WEEK. 3267 03:06:31,737 --> 03:06:33,973 THIS WAS THE SCHEDULING PERSON. 3268 03:06:33,973 --> 03:06:35,808 MY FIRST RESPONSE WAS WE NEVER 3269 03:06:35,808 --> 03:06:37,710 SHOOT THE MESSAGE. THERE IS NO 3270 03:06:37,710 --> 03:06:40,713 BAD NEW JUST NEWS. IT WOULD TURN 3271 03:06:40,713 --> 03:06:42,314 AIRPORT WONDERFUL THING. WE HAD 3272 03:06:42,314 --> 03:06:46,118 A BACK LAUGHING OF NEEDING TO DO 3273 03:06:46,118 --> 03:06:48,587 INFORMANT INTERVIEWS. WE DIDN'T 3274 03:06:48,587 --> 03:06:50,089 SEE PARTICIPANTS FOR A WEEK AND 3275 03:06:50,089 --> 03:06:55,294 WERE ABLE TO THE GET CAUGHT UP. 3276 03:06:55,294 --> 03:06:57,396 THIS ALLOWS FOR QUALITY CONTROL 3277 03:06:57,396 --> 03:06:58,864 AT LEVEL THAT IS DIFFERENT 3278 03:06:58,864 --> 03:06:59,165 OTHERWISE . 3279 03:06:59,165 --> 03:07:05,404 THE LAST PIECE THAT IS M COME 3280 03:07:05,404 --> 03:07:10,409 /* COMING IS FOUR PASS. ONE OF 3281 03:07:10,409 --> 03:07:12,244 THE THINGS AT THE ARE REQUESTS 3282 03:07:12,244 --> 03:07:14,914 AND MEETING WITH OTHER TEAMS ON 3283 03:07:14,914 --> 03:07:16,182 HOW. THERE'S TWO PROGRAMS 3284 03:07:16,182 --> 03:07:17,883 LOOKING AT INCREASING DIVERSITY. 3285 03:07:17,883 --> 03:07:20,352 I'M ENTERING THEM ON NOT ONLY 3286 03:07:20,352 --> 03:07:23,222 HOW DO YOU RECRUIT DIVERSE 3287 03:07:23,222 --> 03:07:23,856 POPULATIONS WITH COMMUNITIES OF 3288 03:07:23,856 --> 03:07:25,257 COLOR BUT BUILD THE SYSTEM, 3289 03:07:25,257 --> 03:07:27,259 TRACK IT, MONITOR IT SO YOU KNOW 3290 03:07:27,259 --> 03:07:31,030 WHERE TO MAKE CHANGES. NEXT 3291 03:07:31,030 --> 03:07:36,001 SLIDE, PLEASE. THIS IS WHAT I 3292 03:07:36,001 --> 03:07:37,803 MEANT WHEN I SAID I THINK IT IS 3293 03:07:37,803 --> 03:07:39,305 IMPORTANT TO HAVE THE RIGHT 3294 03:07:39,305 --> 03:07:40,906 PEOPLE AT THE TABLE. IN MY 3295 03:07:40,906 --> 03:07:42,208 EXPERIENCE WORKING WITH GROUPS 3296 03:07:42,208 --> 03:07:48,914 FROM ALL OVER, I WOULD GO TO 3297 03:07:48,914 --> 03:07:49,615 ADMINI ED 3298 03:07:49,615 --> 03:07:52,218 A ADMINISTER SCORE MEETING. WE 3299 03:07:52,218 --> 03:07:54,086 NEEDED OPERATIONS IN THOSE 3300 03:07:54,086 --> 03:07:55,588 MEETINGS SO BUILT THE SYSTEM IN 3301 03:07:55,588 --> 03:07:59,258 SUCH A MANNER THAT FOR EXAMPLE 3302 03:07:59,258 --> 03:08:04,697 I'M THE LEAD BUT WE GAVE 3303 03:08:04,697 --> 03:08:07,333 DIRECTOR TITLES TO STAFF. EVEN 3304 03:08:07,333 --> 03:08:10,102 THOUGH I'M IN MEETINGS, SHE RUNS 3305 03:08:10,102 --> 03:08:11,370 THE MEETINGS. IN THE MEETINGS 3306 03:08:11,370 --> 03:08:14,440 THE IMAGING CENTER IS 3307 03:08:14,440 --> 03:08:16,242 REPRESENTED. CLINICAL CORE, 3308 03:08:16,242 --> 03:08:17,309 OUTREACH IS THERE SO IF CHANGE 3309 03:08:17,309 --> 03:08:20,613 NEEDS TO HAPPEN WE HAVE 3310 03:08:20,613 --> 03:08:23,949 LEADERSHIP ACROSS GROUP S SO 3311 03:08:23,949 --> 03:08:27,653 WHEN WE SAY WE WILL GO FROM 3312 03:08:27,653 --> 03:08:30,222 SCHEDULING 65 TO 72 THE IMAGING 3313 03:08:30,222 --> 03:08:31,724 CENTER, NO, THIS IS WHAT WE NEED 3314 03:08:31,724 --> 03:08:34,059 TO DO TO KEEP UP. WE GOT MORE 3315 03:08:34,059 --> 03:08:37,163 BLOOD SAMPLES COMING IN. 3316 03:08:37,163 --> 03:08:40,232 EVERYONE CAN MONITOR AND 3317 03:08:40,232 --> 03:08:44,203 PRO INPRO 3318 03:08:44,203 --> 03:08:48,274 PROVIDE FEEDBACK AS TO WHEN TO 3319 03:08:48,274 --> 03:08:50,276 IMPLEMENT CHANGES. THIS ALLOWS 3320 03:08:50,276 --> 03:08:52,545 TEAM TO TAKE HOLD OF THE STUDY 3321 03:08:52,545 --> 03:08:54,480 ITSELF. NEXT SLIDE, PLEASE. THIS 3322 03:08:54,480 --> 03:08:58,851 IS WHAT I MEANT WITH FOREC 3323 03:08:58,851 --> 03:08:59,852 FORECASTING. WE HAVE TRACKED 3324 03:08:59,852 --> 03:09:02,655 DATA ON HOW MANY WE SCHEDULE PER 3325 03:09:02,655 --> 03:09:04,156 WEEK. SO THIS WOULD BE MONTHLY. 3326 03:09:04,156 --> 03:09:07,393 WE KNOW WHEN WE ARE CHANGING THE 3327 03:09:07,393 --> 03:09:08,093 NUMBER OF PEOPLE SCHEDULED BUT 3328 03:09:08,093 --> 03:09:09,528 FOR THE LAST SEVERAL YEARS KNOW 3329 03:09:09,528 --> 03:09:11,764 OUR SHOW-UP RATES BY MONTH. WE 3330 03:09:11,764 --> 03:09:14,366 KNOW IN JANUARY WE NORMALLY HAVE 3331 03:09:14,366 --> 03:09:19,772 A 65% SHOW-UP WITH 35% NO-SHOW 3332 03:09:19,772 --> 03:09:21,207 RATE. SOME OF THESE NUMBERS , 3333 03:09:21,207 --> 03:09:22,875 THE JULY IS THE JANUARY BECAUSE 3334 03:09:22,875 --> 03:09:23,576 DECEMBER AND JANUARY PEOPLE 3335 03:09:23,576 --> 03:09:25,544 DON'T WANT TO SHOW UP, THEY 3336 03:09:25,544 --> 03:09:27,580 DON'T WANT TO DO HOLIDAYS. WHAT 3337 03:09:27,580 --> 03:09:29,081 WE CAN DO WITH THIS AND THEN 3338 03:09:29,081 --> 03:09:30,516 DOING NOW IS SAY OKAY NOT ONLY 3339 03:09:30,516 --> 03:09:32,284 DO WE KNOW WHERE WE WILL BE AT 3340 03:09:32,284 --> 03:09:34,553 THE END OF YEAR 2 BUT BY TIME WE 3341 03:09:34,553 --> 03:09:35,788 GET INTO YEAR THREE THAT WILL BE 3342 03:09:35,788 --> 03:09:37,923 ABLE TO TELL US WHERE WE WILL BE 3343 03:09:37,923 --> 03:09:39,859 AT THE END OF YEAR FIVE. WHEN WE 3344 03:09:39,859 --> 03:09:41,126 ARE READY GOING FOR RENEWAL WE 3345 03:09:41,126 --> 03:09:44,763 KNOW WHAT WILL BE IN THE 3346 03:09:44,763 --> 03:09:49,068 DATABASE AT YEAR TEN. WE KNOW 3347 03:09:49,068 --> 03:09:55,674 WHAT IS GOING TO BE THERE. ONE 3348 03:09:55,674 --> 03:09:57,943 OF THE IMPORTANT REASONS IS PI. 3349 03:09:57,943 --> 03:10:01,380 I GET ASKED WHEN THE METHYL 3350 03:10:01,380 --> 03:10:03,816 AVAILABLE. I SEE FOUR IN THE 3351 03:10:03,816 --> 03:10:05,317 DATABASE BUT NOT ANCESTRY. THIS 3352 03:10:05,317 --> 03:10:07,786 ALLOWS US -- WILL, NOT YET, 3353 03:10:07,786 --> 03:10:11,423 ALLOW US TO HAVE A SYSTEM SO 3354 03:10:11,423 --> 03:10:13,259 THAT NOT ONLY LONG-TERM VISION 3355 03:10:13,259 --> 03:10:15,561 IS YOU CAN LAUGHING IN. WHAT IS 3356 03:10:15,561 --> 03:10:18,097 AVAILABLE, DATABASE OF DATA. HOW 3357 03:10:18,097 --> 03:10:22,434 MANY LIMITS, BUT WHEN IN THE 3358 03:10:22,434 --> 03:10:26,739 DATABASE? NEXT SLIDE, PLEASE. 3359 03:10:26,739 --> 03:10:33,646 THIS IS SOMETHING I GET WEEKLY. 3360 03:10:33,646 --> 03:10:35,514 IT GOES TO THE LEADERSHIP. WHAT 3361 03:10:35,514 --> 03:10:37,116 YOU WILL SEE IS THERE IS A 3362 03:10:37,116 --> 03:10:38,384 TRACKING SYSTEM. BUT IN THE 3363 03:10:38,384 --> 03:10:42,388 EMAIL THERE IS KUDOS. HERE IS 3364 03:10:42,388 --> 03:10:46,525 HOW MANY WE HAVE SEEN SO FOR 3365 03:10:46,525 --> 03:10:50,829 THIS ONE IS HOW MANY A WEEK WE 3366 03:10:50,829 --> 03:10:58,237 NEED TO SEE. WENT UP FROM 26.4 3367 03:10:58,237 --> 03:10:58,837 AND DOWN TO 25.8. WITH KNOW 3368 03:10:58,837 --> 03:11:00,372 TRACKING HOW MANY WE NEED TO 3369 03:11:00,372 --> 03:11:02,074 SEE. THE TEAM GETS TO SEE THE 3370 03:11:02,074 --> 03:11:03,776 NUMBERS GO DOWN AND OTHERS GO 3371 03:11:03,776 --> 03:11:06,211 UP. THEY OWN THAT. THEY SEE HOW 3372 03:11:06,211 --> 03:11:08,480 MANY SCANS WE HAVE DONE, NO-SHOW 3373 03:11:08,480 --> 03:11:12,418 RATES AND HOW MANY DATABASES WE 3374 03:11:12,418 --> 03:11:16,422 HAVE PROVIDED. THE TEAM LOVES 3375 03:11:16,422 --> 03:11:18,590 THAT. THEY LOVE TO HEAR DR. 3376 03:11:18,590 --> 03:11:20,893 MEEKER GOT A KO1 LEAVE RAMMING 3377 03:11:20,893 --> 03:11:23,062 THE DATA. WE SEND OUT SO 3378 03:11:23,062 --> 03:11:24,630 SUCCESSES FOR THE TEAM. IT TAKES 3379 03:11:24,630 --> 03:11:28,467 A VILLAGE TO DO THAT SORT OF 3380 03:11:28,467 --> 03:11:31,470 THING. NEXT SLIDE. THIS IS SOME 3381 03:11:31,470 --> 03:11:34,907 OF THE GRANULARITY. THIS IS A 3382 03:11:34,907 --> 03:11:36,909 SYSTEM I'M WORKING WITH OTHERS. 3383 03:11:36,909 --> 03:11:38,911 IF YOU LOOK AT BOTTOM, THIS IS 3384 03:11:38,911 --> 03:11:41,280 DONE WEEKLY SO I SCROLL DOWN AND 3385 03:11:41,280 --> 03:11:43,215 SEE IT COUPLE YEARS. HOW MANY 3386 03:11:43,215 --> 03:11:44,917 ARE SEEING PROGRESS TOWARD 3387 03:11:44,917 --> 03:11:46,585 MILESTONE. THEN I CAN GO TO 3388 03:11:46,585 --> 03:11:48,754 IMAGING CENTER, SCHEDULING, 3389 03:11:48,754 --> 03:11:50,422 OUTREACH, DATA PORTAL, I KNOW 3390 03:11:50,422 --> 03:12:00,966 HOW MANY REQUESTS, HOW MANY AND 3391 03:12:02,134 --> 03:12:04,370 THIS INFORMS THE MEETINGS. IT IS 3392 03:12:04,370 --> 03:12:05,104 RECIPROCAL COMMUNICATION THAT ED 3393 03:12:05,104 --> 03:12:08,307 A LOUS US TO ADAPT AND FLEX TO 3394 03:12:08,307 --> 03:12:10,042 MEET GOALS AHEAD OF SCHEDULE. 3395 03:12:10,042 --> 03:12:11,677 INSTEAD OF PUSHING THE TEAM WE 3396 03:12:11,677 --> 03:12:13,345 CAN SLOW DOWN AND ALLOW PEOPLE 3397 03:12:13,345 --> 03:12:15,714 TO DO PHONE CALLS AND GET CAUGHT 3398 03:12:15,714 --> 03:12:17,449 UP. WE ALWAYS LIKE TO TRY TO 3399 03:12:17,449 --> 03:12:19,885 SLOW DOWN OVER SUMMERS, WHICH IS 3400 03:12:19,885 --> 03:12:20,819 DIFFICULT. WHICH IS WHEN 3401 03:12:20,819 --> 03:12:24,123 DEADLINES ARE. WE WANT PEOPLE TO 3402 03:12:24,123 --> 03:12:30,095 TAKE VACATIONS. THIS IS WHERE 3403 03:12:30,095 --> 03:12:35,000 WHAT I WAS GETTING AT IS WE KNOW 3404 03:12:35,000 --> 03:12:36,502 THE INFORMATION AND FALLING 3405 03:12:36,502 --> 03:12:38,003 BEHIND. THIS IS WHEN WE DECIDE 3406 03:12:38,003 --> 03:12:39,605 WHEN AND WHERE DO WE HERE 3407 03:12:39,605 --> 03:12:42,741 PEOPLE? A NEW RA FOR SCHEDULING 3408 03:12:42,741 --> 03:12:44,410 OR HERE? ONE OF THE THINGS 3409 03:12:44,410 --> 03:12:45,778 THAT'S COME OUT IS INSTEAD OF 3410 03:12:45,778 --> 03:12:49,982 HIRING A NEW RA FOR THE NEXT 12 3411 03:12:49,982 --> 03:12:55,220 MONTHS WE WILL LOOK AT THE SHOW 3412 03:12:55,220 --> 03:12:57,956 UP RATE AND NO-SHOW. THIS IS 3413 03:12:57,956 --> 03:13:00,125 GETTING PEOPLE BACK, REMINDER, 3414 03:13:00,125 --> 03:13:01,293 INTERVIEWING PEOPLE ONCE THEY 3415 03:13:01,293 --> 03:13:03,362 LEAVE. WHAT ARE THINGS WE CAN DO 3416 03:13:03,362 --> 03:13:06,999 TO HELP INCREASE CONNECTION TO 3417 03:13:06,999 --> 03:13:10,169 THE STUDY? THEN WITH ALL THIS 3418 03:13:10,169 --> 03:13:11,737 COMPONENT IT ALLOWS US TO BE 3419 03:13:11,737 --> 03:13:15,574 ABLE TO KNOW WHERE WE ARE AT AT 3420 03:13:15,574 --> 03:13:19,778 ANY GIVEN TIME SO THIS ALSO 3421 03:13:19,778 --> 03:13:21,313 ALLOWS US TO BETTER COLLABORATE 3422 03:13:21,313 --> 03:13:24,216 WITH INVESTIGATORS. SO WITH YCAP 3423 03:13:24,216 --> 03:13:25,350 FOR EXAMPLE WE KNEW WE WERE 3424 03:13:25,350 --> 03:13:28,020 GOING TO SHARE GWAS. BUT WE NEED 3425 03:13:28,020 --> 03:13:30,122 TO BE ABLE TO -- AT THIS POINT 3426 03:13:30,122 --> 03:13:33,025 WE WILL HAVE IT AND READY TO GO, 3427 03:13:33,025 --> 03:13:35,627 PULLED IT TOGETHER AND NOW THE 3428 03:13:35,627 --> 03:13:41,433 VIEW. NEXT SLIDE, PLEASE. ONE OF 3429 03:13:41,433 --> 03:13:51,977 THE THINGS I THINK IS IMPORTANT. 3430 03:13:54,346 --> 03:13:57,916 WE DIDN'T SAY WHY WE SAID THIS 3431 03:13:57,916 --> 03:14:00,486 IS WHERE WE WANT TO BUILD WITH 3432 03:14:00,486 --> 03:14:04,323 IT. NOT PARTICIPATING WAS A HUGE 3433 03:14:04,323 --> 03:14:06,492 OPPORTUNITY INSTEAD OF 3434 03:14:06,492 --> 03:14:07,526 HINDRANCE. WHAT WE DID IS BUILD 3435 03:14:07,526 --> 03:14:09,862 IT. ONE OF THE THINGS I'M SUPER 3436 03:14:09,862 --> 03:14:11,797 PROUD IS OVER THE LAST COUPLE 3437 03:14:11,797 --> 03:14:14,800 DECADES OUR TEAM SINGLE SITE HAS 3438 03:14:14,800 --> 03:14:16,368 RECRUITED CLOSE TO 12,000 ALL 3439 03:14:16,368 --> 03:14:20,906 FROM DIVERSE COMMUNITIES. RURAL, 3440 03:14:20,906 --> 03:14:22,574 IMPOVERISHED, AFRICAN-AMERICAN, 3441 03:14:22,574 --> 03:14:23,675 HISPANIC. IF YOU LOOK MOST OF 3442 03:14:23,675 --> 03:14:25,310 OUR SENIOR LEADERSHIP HAVE BEEN 3443 03:14:25,310 --> 03:14:35,854 WITH US A DECADE OR LONGER. SO 3444 03:14:40,659 --> 03:14:41,226 IT'S G 3445 03:14:41,226 --> 03:14:42,761 WHEN THEY JOIN THEY DON'T OFTEN 3446 03:14:42,761 --> 03:14:44,730 LEAVE. OUR SYSTEM IS CUSTOM. WE 3447 03:14:44,730 --> 03:14:46,131 BUILT IT SO PEOPLE CAN GET THE 3448 03:14:46,131 --> 03:14:48,267 DATA. THAT'S BEEN THE GOAL. TO 3449 03:14:48,267 --> 03:14:52,337 GET IT TO LONA. ARTHUR IS AN 3450 03:14:52,337 --> 03:14:54,339 MPI. THEY HAVE SCANS. IN THE 3451 03:14:54,339 --> 03:14:55,541 PROCESS NOW AND EXPECT IN JUNE 3452 03:14:55,541 --> 03:14:59,978 THE DATABASE TO BE THERE. WE ARE 3453 03:14:59,978 --> 03:15:04,616 DUMPING GENOMICS IN NOW. WE HAVE 3454 03:15:04,616 --> 03:15:09,955 BEEN ABLE TO SUPPORT OVER 350 3455 03:15:09,955 --> 03:15:11,156 DATABASES IN DIFFERENT COUNTRIES 3456 03:15:11,156 --> 03:15:14,660 IN THE LAST 18 MONTHS. I THINK 3457 03:15:14,660 --> 03:15:17,496 WE HAVE SUPPORTED FIVE TRAINING 3458 03:15:17,496 --> 03:15:19,965 GRANTS AND TEN ARE EQUIVALENT IN 3459 03:15:19,965 --> 03:15:22,668 THE LAST 36 SO LOTS OF THER 3460 03:15:22,668 --> 03:15:24,703 ANCILLARY THINGS. PEOPLE ARE 3461 03:15:24,703 --> 03:15:27,406 LEVERAGING DIANE TO COLLABORATE. 3462 03:15:27,406 --> 03:15:29,308 ABCDS CROSS COLLABORATES SO THE 3463 03:15:29,308 --> 03:15:31,510 DATA IS BEING LEVERAGED 3464 03:15:31,510 --> 03:15:38,951 SUBSTANTIALLY. NEXT SLIDE, 3465 03:15:38,951 --> 03:15:41,987 PLEASE. THERE'S A BUNCH OF 3466 03:15:41,987 --> 03:15:43,088 SLIDES. WANTED TO HIGHLIGHTS 3467 03:15:43,088 --> 03:15:44,189 JUNIOR INVESTIGATORS BECAUSE WE 3468 03:15:44,189 --> 03:15:46,258 ARE TRAINING A LOT OF 3469 03:15:46,258 --> 03:15:47,426 SCIENTISTS. THE DECK YOU WILL 3470 03:15:47,426 --> 03:15:49,127 HAVE ACCESS TO HAS THAT 3471 03:15:49,127 --> 03:15:53,332 INFORMATION BUT DIDN'T WANT TO 3472 03:15:53,332 --> 03:15:54,166 GO OVER TIME. SO I'M GO TO PAUSE 3473 03:15:54,166 --> 03:15:55,534 FOR QUESTIONS OR COMMENTS. THANK 3474 03:15:55,534 --> 03:15:58,637 YOU FOR YOUR TIME. 3475 03:15:58,637 --> 03:16:04,876 3476 03:16:04,876 --> 03:16:06,278 >> THANK YOU DR. RYAN. GREAT 3477 03:16:06,278 --> 03:16:08,347 TALK. LINDA, WANT TO START US 3478 03:16:08,347 --> 03:16:10,182 OFF? 3479 03:16:10,182 --> 03:16:15,921 >> THAT WAS FANTASTIC, GREAT. 3480 03:16:15,921 --> 03:16:17,656 I MIGHT HAVE MISSED IT BUT DO 3481 03:16:17,656 --> 03:16:20,158 YOU HAVE PLANS TO HAVE ANY OF 3482 03:16:20,158 --> 03:16:22,527 YOUR PARTICIPANTS TO COME BACK 3483 03:16:22,527 --> 03:16:24,096 FOR LONGITUDINAL INFORMATION ON 3484 03:16:24,096 --> 03:16:24,863 THINGS YOU MEASURE? 3485 03:16:24,863 --> 03:16:28,166 >> YEAH, I DIDN'T SAY THAT. 3486 03:16:28,166 --> 03:16:29,534 THANKS FOR THAT. SO YES, 3487 03:16:29,534 --> 03:16:32,371 EVERYONE COMES BACK EVERY 24 3488 03:16:32,371 --> 03:16:34,239 MONTHS. WE ACTUALLY HAVE OVER 3489 03:16:34,239 --> 03:16:36,441 1500 LONGITUDINAL ALREADY AND 3490 03:16:36,441 --> 03:16:39,177 PUSHING ALMOST A THOUSAND 3491 03:16:39,177 --> 03:16:40,479 LONGITUDINAL AMYLOID SCANS. IT 3492 03:16:40,479 --> 03:16:43,782 IS A LONGITUDINAL STUDY. SORRY 3493 03:16:43,782 --> 03:16:47,419 ABOUT THAT, LINDA. 3494 03:16:47,419 --> 03:16:49,321 >> THANKS FOR THE 3495 03:16:49,321 --> 03:16:50,422 PRESENTATION. A BIG QUESTION. 3496 03:16:50,422 --> 03:16:53,625 THE SUCCESS YOU HAVE HAD IS 3497 03:16:53,625 --> 03:16:55,627 EXPLAINED AND LOTS OF WAYS YOU 3498 03:16:55,627 --> 03:16:57,262 PRESENTED BY ORGANIZATIONAL 3499 03:16:57,262 --> 03:17:00,032 STRATEGIES. IN PARTICULAR YOUR 3500 03:17:00,032 --> 03:17:02,801 ABILITY TO RECRUIT DIVERSE 3501 03:17:02,801 --> 03:17:03,869 POPULATION, THE ONLY SPECIFIC 3502 03:17:03,869 --> 03:17:05,070 REFERENCE YOU MADE WAS YOUR 3503 03:17:05,070 --> 03:17:06,538 PHYSICAL LOCATION. YOU HAPPEN TO 3504 03:17:06,538 --> 03:17:09,107 BE IN AN AREA THAT IS DIVERSE. 3505 03:17:09,107 --> 03:17:10,942 DO YOU WANT TO COMMENT ON THAT 3506 03:17:10,942 --> 03:17:13,645 AND WHETHER THERE ARE OTHER 3507 03:17:13,645 --> 03:17:15,180 STRAT DPIS THAT MAKE YOU 3508 03:17:15,180 --> 03:17:17,549 RELATIVELY UNIQUELY SUCCESSFUL, 3509 03:17:17,549 --> 03:17:19,685 INCREDIBLE DIVERSITY IN 3510 03:17:19,685 --> 03:17:20,218 RECRUITMENT? 3511 03:17:20,218 --> 03:17:21,887 >> YEAH, I ALWAYS BALANCE 3512 03:17:21,887 --> 03:17:24,690 WITH HOW MUCH. I COULD SPEND 3513 03:17:24,690 --> 03:17:25,824 DAYS TALKING ABOUT JUST THAT 3514 03:17:25,824 --> 03:17:28,493 COMPONENT. SO WE HAVE BUILT A 3515 03:17:28,493 --> 03:17:30,996 VERY STRONG TIE WITH THE LOCAL 3516 03:17:30,996 --> 03:17:33,165 COMMUNITY. WE ARE IN THE 3517 03:17:33,165 --> 03:17:34,800 COMMUNITY, OVER 200 EVENTS A 3518 03:17:34,800 --> 03:17:36,401 YEAR. I PERSONALLY SPEAK TO THE 3519 03:17:36,401 --> 03:17:38,537 COMMUNITY ON A REGULAR BASIS, 3520 03:17:38,537 --> 03:17:40,172 MEET COMMUNITY LEADERS ARE PART 3521 03:17:40,172 --> 03:17:43,375 F OUR STUDY AND VIOLATE 3522 03:17:43,375 --> 03:17:44,943 CONFIDENTIALITY CONSTANTLY EVEN 3523 03:17:44,943 --> 03:17:47,312 ON MEDIA, HEY I'M PART OF THE 3524 03:17:47,312 --> 03:17:50,315 STUDY. WE HAVE SPENT OVER A 3525 03:17:50,315 --> 03:17:51,350 DECADE BUILDING THESE COMMUNITY 3526 03:17:51,350 --> 03:17:52,751 TIES. WE HAVE A UNIQUE APPROACH 3527 03:17:52,751 --> 03:17:54,619 IN THAT WE DO A STRONG 3528 03:17:54,619 --> 03:17:57,489 GRASSROOTS APPROACH. SO WE HAVE 3529 03:17:57,489 --> 03:17:59,257 ALSO THE COMMUNITY -- LARGE 3530 03:17:59,257 --> 03:18:01,093 COMMUNITY ENGAGEMENT SO AN 3531 03:18:01,093 --> 03:18:04,162 ENTIRE MEDIA TEAM. WE DO SOCIAL 3532 03:18:04,162 --> 03:18:07,232 MEDIA OUTP REACH. WE DO 3533 03:18:07,232 --> 03:18:07,666 TELEVISION, RADIO . 3534 03:18:07,666 --> 03:18:10,001 THE LARGEST BLACK-OWNED 3535 03:18:10,001 --> 03:18:11,536 SYNDICATED RADIO STATION IN THE 3536 03:18:11,536 --> 03:18:12,771 UNITED STATES IS IN DALLAS. THEY 3537 03:18:12,771 --> 03:18:15,841 WERE SO EXCITED THAT THEY AIRED 3538 03:18:15,841 --> 03:18:18,510 OUR RECRUITMENT FOR THE BLACK 3539 03:18:18,510 --> 03:18:19,711 PARTICIPANTS FOR FREE. THEY 3540 03:18:19,711 --> 03:18:21,279 BUILT IT. PUT IT TOGETHER. THEY 3541 03:18:21,279 --> 03:18:25,851 WERE SO EXCITED. THERE'S THE FOR 3542 03:18:25,851 --> 03:18:29,988 EXAMPLE THE STATE FAIR HAS A 3543 03:18:29,988 --> 03:18:32,424 LARGE FOOTBALL GAME WITH HBUs. 3544 03:18:32,424 --> 03:18:36,862 WE ARE THERE AND ON THE JUMBO 3545 03:18:36,862 --> 03:18:40,499 TRON AS ESPN IS ON. EVERYONE IS 3546 03:18:40,499 --> 03:18:45,270 EXCITED. I'VE BE ON SIBL WILKES, 3547 03:18:45,270 --> 03:18:46,438 LATERIS, WITH HIM YESTERDAY SO 3548 03:18:46,438 --> 03:18:48,473 WE ENGAGE COMMUNITY LEADERS 3549 03:18:48,473 --> 03:18:50,742 THEMSELVES. THE LADY WHO OWNS 3550 03:18:50,742 --> 03:18:52,911 THE MEDIA GROUP WE ARE ENGAGED 3551 03:18:52,911 --> 03:18:55,113 WITH, SHE IS THE ONE MCDONALD'S 3552 03:18:55,113 --> 03:18:58,016 WENT TO WHEN THEY WANTED TO DO A 3553 03:18:58,016 --> 03:18:59,918 NATIONAL CAMPAIGN TO THE BLACK 3554 03:18:59,918 --> 03:19:01,086 COMMUNITY. SAME THING IN 3555 03:19:01,086 --> 03:19:03,655 HISPANIC COMMUNITY. HISPANIC 3556 03:19:03,655 --> 03:19:05,457 CHAMBER OF COMMERCE, ET CETERA. 3557 03:19:05,457 --> 03:19:07,559 SO, TO ME, THE COMMUNITY 3558 03:19:07,559 --> 03:19:09,060 COMPONENT IS NO MORE DIFFICULT 3559 03:19:09,060 --> 03:19:11,329 THAN BUILDING THE CLINIC. IT IS 3560 03:19:11,329 --> 03:19:18,203 VERY DFRPT, TAKES A LOT OF TIME 3561 03:19:18,203 --> 03:19:20,405 YOU CANNOT HELICOPTER RESEARCH. 3562 03:19:20,405 --> 03:19:22,073 YOU HAVE TO BUILD IT. ONE OF THE 3563 03:19:22,073 --> 03:19:23,475 THINGS PEOPLE DON'T REALIZE IS, 3564 03:19:23,475 --> 03:19:25,143 YOU NEVER GO IN ASKING FOR 3565 03:19:25,143 --> 03:19:26,511 SOMETHING. YOU GO TO THE 3566 03:19:26,511 --> 03:19:27,979 COMMUNITY WITH, ALL RIGHT. WHAT 3567 03:19:27,979 --> 03:19:29,514 WOULD YOU LIKE? HERE IS WHAT WE 3568 03:19:29,514 --> 03:19:31,082 ARE INTERESTED IN AND NEED TO 3569 03:19:31,082 --> 03:19:32,818 UNDERSTAND AGING. WHAT DO YOU 3570 03:19:32,818 --> 03:19:36,354 NEED? WE GIVE TALKS ON DIABETES, 3571 03:19:36,354 --> 03:19:37,255 HYPERTENSION. IF THE COMMUNITY 3572 03:19:37,255 --> 03:19:41,460 SAYS WE NEED TO TALK ON SMOKINGS 3573 03:19:41,460 --> 03:19:48,733 A -- SMOKING ADOLESCENTS. IT IS 3574 03:19:48,733 --> 03:19:50,836 BUILDING A RELATIONSHIP. I WOULD 3575 03:19:50,836 --> 03:19:52,871 RATHER GO TO THE COMMUNITY. IT 3576 03:19:52,871 --> 03:19:54,906 IS MY PEOPLE AND I LOVE VERY 3577 03:19:54,906 --> 03:19:58,343 MUCH. WE HAVE VERY STRONGLY 3578 03:19:58,343 --> 03:20:08,086 CONN 3579 03:20:08,086 --> 03:20:10,155 CONNECTED. HOW DO YOU TAKE THE 3580 03:20:10,155 --> 03:20:16,595 TIME TO STRAT GUISTRAT GUISE AN 3581 03:20:16,595 --> 03:20:17,062 IMPLEMENT. 3582 03:20:17,062 --> 03:20:18,230 >> DAVID, FRANK? 3583 03:20:18,230 --> 03:20:20,065 >> I LOVE THE WORK AND THE 3584 03:20:20,065 --> 03:20:22,801 ORGANIZATION AND STRUCTURE. ARE 3585 03:20:22,801 --> 03:20:24,503 YOU COLLECTING BROAD 3586 03:20:24,503 --> 03:20:27,606 BIOMARK ERS, UNLESS I MISSED IT? 3587 03:20:27,606 --> 03:20:30,308 >> ABSOLUTELY, FULL SCALE 3588 03:20:30,308 --> 03:20:35,947 OMIX. METHYL, PROTEOMICS, MET 3589 03:20:35,947 --> 03:20:37,349 TAB LCHL, ALL. 3590 03:20:37,349 --> 03:20:40,051 >> I'M TALKING AMYLOID AND 3591 03:20:40,051 --> 03:20:41,920 TOW SETS. 3592 03:20:41,920 --> 03:20:47,325 >> WE HAVE BLOOD AMYLOID, 3593 03:20:47,325 --> 03:20:51,162 TOW, SAMOA. WE HAVE OTHER 3594 03:20:51,162 --> 03:20:54,466 GROUPS, 181, 217, GFAT. EMERGING 3595 03:20:54,466 --> 03:20:56,468 MARK ERS WE ARE LOOKING. IF WE 3596 03:20:56,468 --> 03:20:59,237 DON'T HAVE THEM WE ARE ADDING 3597 03:20:59,237 --> 03:21:00,539 THEM. ALL THOSE ARE THERE. IF 3598 03:21:00,539 --> 03:21:04,042 THEY ARE NOT THEY WILL BE THERE. 3599 03:21:04,042 --> 03:21:07,512 3600 03:21:07,512 --> 03:21:08,213 TERRIFIC, THANK YOU. 3601 03:21:08,213 --> 03:21:10,048 >> THANK YOU. I KNOW WE HAVE 3602 03:21:10,048 --> 03:21:11,850 LIMITED TIME BUT BRIEFLY CAN 3603 03:21:11,850 --> 03:21:14,352 SOMEBODY BE ON A THER PETE IK 3604 03:21:14,352 --> 03:21:15,453 AND STILL BE IN THE TRIAL? I 3605 03:21:15,453 --> 03:21:17,222 THINK THIS IS M DOING UP MORE 3606 03:21:17,222 --> 03:21:20,458 AND MORE IN LONGITUDINAL 3607 03:21:20,458 --> 03:21:20,825 STUDIES. 3608 03:21:20,825 --> 03:21:22,494 >> SO SOMEONE IS PRESCRIBED 3609 03:21:22,494 --> 03:21:26,464 AN AMYLOID DRUG -- WE DON'T 3610 03:21:26,464 --> 03:21:28,033 REMOVE PEOPLE. YOU ARE IN UNTIL 3611 03:21:28,033 --> 03:21:31,803 YOU SAY YOU ARE NOT IN. WE DON'T 3612 03:21:31,803 --> 03:21:33,538 EXCLUDE, UNLESS WE MUST. IF 3613 03:21:33,538 --> 03:21:35,206 SOMEONE GOES INTO A TRIAL 3614 03:21:35,206 --> 03:21:37,275 NORMALLY TRIALS EXCLUDE THEM BUT 3615 03:21:37,275 --> 03:21:40,912 WE DON'T REMOVE THEM. WE WILL 3616 03:21:40,912 --> 03:21:42,581 SIMPLY PROVIDE A GAP AND SAY AS 3617 03:21:42,581 --> 03:21:44,316 LONG AS YOU ARE IN THE TRIAL, 3618 03:21:44,316 --> 03:21:45,951 WHEN YOU ARE DONE, COME BACK. 3619 03:21:45,951 --> 03:21:47,552 THEY ARE WITH US. WE ARE 3620 03:21:47,552 --> 03:21:50,021 MONITORING THAT. WE HAVEN'T HAD 3621 03:21:50,021 --> 03:21:51,957 ONE YET GO ON ONE OF THE DRUGS. 3622 03:21:51,957 --> 03:21:58,797 THAT IS NOT SURPRISING 3623 03:21:58,797 --> 03:22:00,065 GHOOIVGHOOIV GIVEN 3624 03:22:00,065 --> 03:22:03,702 THE COMMUNITIES AND ACCESS. WE 3625 03:22:03,702 --> 03:22:05,170 WILL MONITOR IT. 3626 03:22:05,170 --> 03:22:07,305 >> AN ARTICLE I WAS READING 3627 03:22:07,305 --> 03:22:09,374 THIS, YOU ARE SO CENTRALIZED, 3628 03:22:09,374 --> 03:22:10,976 YOU AND YOUR TEAM ADDRESSED THIS 3629 03:22:10,976 --> 03:22:13,011 COMPLICATED AREA. I WAS READING 3630 03:22:13,011 --> 03:22:15,380 ABOUT THE POINT OF VIEW THAT 3631 03:22:15,380 --> 03:22:18,083 SOCIOECONOMIC -- THIS IS FOR 3632 03:22:18,083 --> 03:22:21,386 LATE-ONSET ALZHEIMER'S, RISK OR 3633 03:22:21,386 --> 03:22:23,488 PROGRESSION. SOCIOECONOMIC 3634 03:22:23,488 --> 03:22:24,889 FACTORS ARE MORE POWERFUL THAN 3635 03:22:24,889 --> 03:22:29,494 ANY GENETIC FACTOR. YOU ARE 3636 03:22:29,494 --> 03:22:30,729 COLLECTING BOTH SO -- 3637 03:22:30,729 --> 03:22:32,163 >> I CAN TELL YOU THAT WE 3638 03:22:32,163 --> 03:22:34,065 HAVE DATA NOW SUGGESTING LIKE 3639 03:22:34,065 --> 03:22:36,134 SOME PRIOR DATA HAS TALKED ABOUT 3640 03:22:36,134 --> 03:22:37,902 CERTAIN SOCIOECONOMIC FACTORS 3641 03:22:37,902 --> 03:22:41,106 ARE NOT RELATED TO AMYLOID OR 3642 03:22:41,106 --> 03:22:42,674 WHATEVER. WHAT WE THINK IS 3643 03:22:42,674 --> 03:22:44,943 THERE'S BEEN RESTRICTED RANGE IN 3644 03:22:44,943 --> 03:22:46,778 SOCIOECONOMIC REPRESENTATION IN 3645 03:22:46,778 --> 03:22:48,546 STUDIES. WE ABSOLUTELY SEE 3646 03:22:48,546 --> 03:22:50,482 SOCIOECONOMIC FACTORS BROADLY 3647 03:22:50,482 --> 03:22:53,585 DEFINED. SO WHERE YOU LIVE, ET 3648 03:22:53,585 --> 03:22:58,923 CETERA. VERY STRONGLY LAIN 3649 03:22:58,923 --> 03:23:03,495 LINKED, INCLUDING AMYLOID, TOW, 3650 03:23:03,495 --> 03:23:05,563 NEUROGENERATION, WHICH IS WHAT I 3651 03:23:05,563 --> 03:23:07,399 WAS GETTING AT EARLIER. I DON'T 3652 03:23:07,399 --> 03:23:09,334 THINK WE CAN UNDERSTAND THE 3653 03:23:09,334 --> 03:23:11,803 BRIAN BIOLOGY OF AGING IN 3654 03:23:11,803 --> 03:23:14,572 ABSENCE OF SOCIAL YOU CULTURAL 3655 03:23:14,572 --> 03:23:16,307 FRAME. DATA IS BEARING MORE AND 3656 03:23:16,307 --> 03:23:18,109 MORE OUT. EVEN PEOPLE LOOKING, 3657 03:23:18,109 --> 03:23:20,879 THERE IS ABSTRACT GOING OUT. 3658 03:23:20,879 --> 03:23:22,013 PERCEIVED RACISM AS A VERY 3659 03:23:22,013 --> 03:23:26,017 STRONG FACTOR ASSOCIATED WITH 3660 03:23:26,017 --> 03:23:29,387 EVEN IM IMAGING AMONG HISPANIC 3661 03:23:29,387 --> 03:23:33,425 AND NON-AMERICANS BUT NOT 3662 03:23:33,425 --> 03:23:35,960 NON-HISPANIC WHITES. DIABETES 3663 03:23:35,960 --> 03:23:37,595 RELATED TO TOW AMONG HISPANICS. 3664 03:23:37,595 --> 03:23:39,464 IT IS COMPLICATED BUT THAT IS 3665 03:23:39,464 --> 03:23:40,832 ENCOURAGING THAT. IS HOW WE GET 3666 03:23:40,832 --> 03:23:42,667 TO PRECISION MANAGED APPROACHES. 3667 03:23:42,667 --> 03:23:45,170 WITHOUT STUDYING SOCIAL OWE 3668 03:23:45,170 --> 03:23:47,439 CULTURAL DETERMINANTS IT IS LIKE 3669 03:23:47,439 --> 03:23:48,773 STICKING OUR HEAD IN THE DIRT. 3670 03:23:48,773 --> 03:23:50,508 >> I LOVE THAT. WHAT YOU ARE 3671 03:23:50,508 --> 03:23:52,711 DOING SO SO IMPORTANT. IT IS SO 3672 03:23:52,711 --> 03:23:55,547 EASY TO STAY IN A COMFORT ZONE 3673 03:23:55,547 --> 03:23:59,217 OF GENETIC AND BIOLOGIC BUT FACT 3674 03:23:59,217 --> 03:24:00,585 SOCIOECONOMIC STATUS CAN TRUMP 3675 03:24:00,585 --> 03:24:01,453 THAT IS SO IMPORTANT SO THANK 3676 03:24:01,453 --> 03:24:02,554 YOU FOR DOING THAT. 3677 03:24:02,554 --> 03:24:05,023 >> THANKS, FRANK. 3678 03:24:05,023 --> 03:24:07,592 >> ALL RIGHT. THANK YOU AGAIN 3679 03:24:07,592 --> 03:24:11,763 DR. RYAN. REALLY FANTASTIC TALK. 3680 03:24:11,763 --> 03:24:14,299 THANKS FOR YIELDING ALL OUR 3681 03:24:14,299 --> 03:24:16,201 QUESTIONS TOO. I APPRECIATE. 3682 03:24:16,201 --> 03:24:20,538 THERE IS A FEW COMMENTS AND 3683 03:24:20,538 --> 03:24:24,209 KUDOS IN THE CHAT ALSO. ALL 3684 03:24:24,209 --> 03:24:26,211 RIGHT. MOVING ON WE ARE NEXT 3685 03:24:26,211 --> 03:24:29,514 STOP WE ARE GOING TO BE HEAR ING 3686 03:24:29,514 --> 03:24:31,349 FROM OUR INTRAMURAL PROGRAM SO I 3687 03:24:31,349 --> 03:24:32,984 WILL TURN THIS OVER TO DIRECTOR 3688 03:24:32,984 --> 03:24:43,628 OF NIA'S INTRAMURAL PROGRAM DR. 3689 03:24:44,195 --> 03:24:44,362 FRUGI. 3690 03:24:44,362 --> 03:24:46,164 >> INTERESTING DAY. I WILL 3691 03:24:46,164 --> 03:24:48,600 SAY I WAS GLAD TO BE HERE AND 3692 03:24:48,600 --> 03:24:51,269 LISTENING. WE WILL START TALKING 3693 03:24:51,269 --> 03:24:53,905 ABOUT THE INTRA MURAL PROGRAM 3694 03:24:53,905 --> 03:24:56,608 AND INVITING THE SPEAKER MARK 3695 03:24:56,608 --> 03:25:00,812 COOKSON, RECENTLY NOMINATED 3696 03:25:00,812 --> 03:25:07,152 CHIEF OF NEUROGENETIC AND EXPERT 3697 03:25:07,152 --> 03:25:13,458 IN BIOLOGY AND ITS IMPORT IN 3698 03:25:13,458 --> 03:25:16,528 PARKINSON'S AND ALSO HAVE BEEN 3699 03:25:16,528 --> 03:25:21,966 INVOLVED IN LARGE PROJECT , THE 3700 03:25:21,966 --> 03:25:25,103 WAY THEY GENERATE THE CELLS SO 3701 03:25:25,103 --> 03:25:27,539 CAN BECOME AVAILABLE TO 3702 03:25:27,539 --> 03:25:33,945 COMMUNITY AND SEE MUTATION. I 3703 03:25:33,945 --> 03:25:36,481 LIKE TO INVITE MARK TO OPEN WITH 3704 03:25:36,481 --> 03:25:41,619 THIS PRESENTATION. WE MAY BE IN 3705 03:25:41,619 --> 03:25:46,090 THE CLOSED SESSION. THE PROGRAM 3706 03:25:46,090 --> 03:25:48,593 AND I WILL ADDRESS QUESTIONS IF 3707 03:25:48,593 --> 03:25:50,895 YOU HAVE ANY QUESTIONS. MARK. 3708 03:25:50,895 --> 03:25:53,498 >> YEAH GREAT, THANK YOU, 3709 03:25:53,498 --> 03:25:56,935 LUIGI. GREAT TO MEET EVERYONE 3710 03:25:56,935 --> 03:25:58,837 TODAY. WONDERFUL CHANCE TO 3711 03:25:58,837 --> 03:26:00,505 SPEAK. IF I COULD HAVE THE 3712 03:26:00,505 --> 03:26:03,074 SLIDES UP. JASMINE SHOULD BE 3713 03:26:03,074 --> 03:26:06,778 SHOWING THEM. AWESOME, THANKS. 3714 03:26:06,778 --> 03:26:09,981 SO WHAT PROMPTED THIS 3715 03:26:09,981 --> 03:26:11,516 PRESENTATION TODAY WAS THE FACT 3716 03:26:11,516 --> 03:26:13,384 THAT MANY OF YOU KNOW OUR 3717 03:26:13,384 --> 03:26:15,186 INTRAMURAL LABS ARE REVIEWED 3718 03:26:15,186 --> 03:26:19,123 EVERY FOUR YEARS. OURS WAS A 3719 03:26:19,123 --> 03:26:24,128 COUPLE YEAR AGO SO WHAT I HAVE 3720 03:26:24,128 --> 03:26:26,097 SCHEMATIC HIGH-LEVEL OVER VIEW. 3721 03:26:26,097 --> 03:26:27,565 THEN I WILL TRANSITION TO THINGS 3722 03:26:27,565 --> 03:26:31,769 THAT ARE NEWER WE HAVE MOSTED 3723 03:26:31,769 --> 03:26:40,478 THE LAST COUPLE YEARS. BUILDING 3724 03:26:40,478 --> 03:26:43,181 OFF THE LAST TALK, INCREDIBLY 3725 03:26:43,181 --> 03:26:49,787 IMPRESSED ABOUT MULL FACTORIAL 3726 03:26:49,787 --> 03:26:51,823 NATURE OF THE DISORDERS, I WILL 3727 03:26:51,823 --> 03:26:55,193 FOCUS ON GENETICS AND REASON 3728 03:26:55,193 --> 03:26:57,161 THAT IS RELEVANT TO YOU. THE 3729 03:26:57,161 --> 03:26:59,497 REASON WE ARE PART OF INTRAMURAL 3730 03:26:59,497 --> 03:27:01,666 IS HIGHLIGHTED BY THIS. THIS IS 3731 03:27:01,666 --> 03:27:03,768 FROM PARKINSON'S DISEASE. THIS 3732 03:27:03,768 --> 03:27:05,136 IS A MACHINE LEARNING APPROACH 3733 03:27:05,136 --> 03:27:06,971 LOOKING AT VARIOUS FACTORS THAT 3734 03:27:06,971 --> 03:27:16,180 CAN BE MEASURED AND CLASSIFIED. 3735 03:27:16,180 --> 03:27:17,882 IF YOU LOOK AT THINGS THAT 3736 03:27:17,882 --> 03:27:22,487 DETERMINE RISK, NON-GENETIC, 3737 03:27:22,487 --> 03:27:23,821 NON-AGING FACTORS ARE 3738 03:27:23,821 --> 03:27:24,956 SIGNIFICANT IMPORTANT HOWEVER SO 3739 03:27:24,956 --> 03:27:27,392 ARE GENETIC FACTORS, RIGHT. SO 3740 03:27:27,392 --> 03:27:29,894 YOU CAN COME UP WITH VARIOUS 3741 03:27:29,894 --> 03:27:31,562 ITERATIONS OF THIS BUT YOU END 3742 03:27:31,562 --> 03:27:34,032 UP WITH THE SAME THING. GENETIC 3743 03:27:34,032 --> 03:27:36,801 RISKS, NON-GENETIC RISKS 3744 03:27:36,801 --> 03:27:38,770 INCLUDING SOCIAL CONSTRUCTS ON 3745 03:27:38,770 --> 03:27:42,607 AGING AND ALL INTERACT TO GIVE 3746 03:27:42,607 --> 03:27:48,880 RISK OF DISEASE. WE HAVE 3747 03:27:48,880 --> 03:27:50,315 APPROACHED GENETIC NOT BECAUSE 3748 03:27:50,315 --> 03:27:53,451 IT IS MORE IMPORTANT BUT MORE 3749 03:27:53,451 --> 03:27:56,154 SCALEABLE AND REPRODUCIBLE 3750 03:27:56,154 --> 03:27:59,524 SCIENCE. THE NEXT SLIDE. SO 3751 03:27:59,524 --> 03:28:00,925 AGAIN, FIRST PART IS REALLY 3752 03:28:00,925 --> 03:28:03,061 ABOUT THE WORK WE HAVE DONE. SO 3753 03:28:03,061 --> 03:28:05,430 WHEN WE TALK ABOUT LAPSE IN THE 3754 03:28:05,430 --> 03:28:06,731 INTRAMURAL PROGRAM MANY ARE 3755 03:28:06,731 --> 03:28:11,336 MULTI -PI LABS. EACH RUNS 3756 03:28:11,336 --> 03:28:17,008 RELATIVELY SMALL TEAM. THIS IS 3757 03:28:17,008 --> 03:28:17,608 OUR CURRENT COHORT . 3758 03:28:17,608 --> 03:28:18,476 THE THING I WANT EVERYONE TO 3759 03:28:18,476 --> 03:28:21,913 UNDERSTAND IS FIRST OF ALL 3760 03:28:21,913 --> 03:28:27,719 WITHIN THIS THERE ARE IMPORTANT 3761 03:28:27,719 --> 03:28:29,854 DISTINCTIONS FROM WHAT PEOPLE 3762 03:28:29,854 --> 03:28:33,091 DO. CLINICAL RESEARCH, HUMAN 3763 03:28:33,091 --> 03:28:34,425 GENETICS AND POPULATION SCALE 3764 03:28:34,425 --> 03:28:36,928 AND MOUSE. LUIGI HIGHLIGHTED 3765 03:28:36,928 --> 03:28:40,264 ALREADY, THAT IS ACTUALLY MY 3766 03:28:40,264 --> 03:28:43,534 AREA OF INTEREST. NEXT SLIDE. I 3767 03:28:43,534 --> 03:28:44,902 THINK IT IS IMPORTANT SO WE HAVE 3768 03:28:44,902 --> 03:28:51,776 BEEN IN EXISTENCE FOR 22 YEARS. 3769 03:28:51,776 --> 03:28:55,313 SO NOT QUITE HALF THE TIME NIA 3770 03:28:55,313 --> 03:28:59,517 HAS BEEN HERE. BUT WE HAVE MADE 3771 03:28:59,517 --> 03:29:02,653 BIG IMPACT IN NEURODEGENERATIVE 3772 03:29:02,653 --> 03:29:04,355 DISEASES WE STUDY. I WOULD SAY 3773 03:29:04,355 --> 03:29:07,225 ABOUT HALF THE LAB IS FOCUSED ON 3774 03:29:07,225 --> 03:29:10,995 GENETICS. THAT STARTS MONOGENIC 3775 03:29:10,995 --> 03:29:13,664 AND MOVED TO GENO WIDE STUDIES. 3776 03:29:13,664 --> 03:29:16,234 WE HAVE BEEN RESPONSIBLE FOR 3777 03:29:16,234 --> 03:29:18,703 DISCOVERY OF MAJOR IN 3778 03:29:18,703 --> 03:29:25,176 PARKINSON'S AND THE FTD SPECTRUM 3779 03:29:25,176 --> 03:29:29,714 SO LOOK TO 72 AS WELL AS RARE 3780 03:29:29,714 --> 03:29:36,521 ALILS IN ALZHEIMER'S. THE TWO 3781 03:29:36,521 --> 03:29:41,859 PAPERS IS ESTABLISH ALREADYING 3782 03:29:41,859 --> 03:29:44,695 -- ESTABLISHING A RISK FACTOR. I 3783 03:29:44,695 --> 03:29:50,768 COME BACK TO SOME OF THIS LATER. 3784 03:29:50,768 --> 03:29:53,905 THIS OTHER HALF WORKS ON MODELS. 3785 03:29:53,905 --> 03:29:56,140 SOME OF THE WORK HAS BEEN -- WE 3786 03:29:56,140 --> 03:29:58,242 HAVEN'T TAKEN CLINICAL TRIALS 3787 03:29:58,242 --> 03:29:59,677 BUT HAS BEEN INFORMATIVE. SOME 3788 03:29:59,677 --> 03:30:10,188 OF THE IDEAS THAT COME ARE IN 3789 03:30:11,789 --> 03:30:12,924 PARKINSONS, WHICH IS GREAT. 3790 03:30:12,924 --> 03:30:14,792 ANOTHER THING IS NOT WE ARE SO 3791 03:30:14,792 --> 03:30:18,596 HAPPY WITH WHAT WE FOUND BUT 3792 03:30:18,596 --> 03:30:25,903 STILL PUSHING TO MOVE FORWARD. I 3793 03:30:25,903 --> 03:30:27,505 WANT TO EMPHASIZE THEY ARE 3794 03:30:27,505 --> 03:30:31,142 DISTINCT THE INTERACTIONS ARE 3795 03:30:31,142 --> 03:30:34,979 IMPORTANT. NEXT SLIDE. JUST 3796 03:30:34,979 --> 03:30:41,119 AGAIN SORT OF VERY BIG OVERVIEW. 3797 03:30:41,119 --> 03:30:43,721 THESE THEME SLIDES WERE DONE BY 3798 03:30:43,721 --> 03:30:45,723 MATSON, TOOK OUR PAPERS AND 3799 03:30:45,723 --> 03:30:49,260 CLASSIFIED THEM. YOU CAN SEE IN 3800 03:30:49,260 --> 03:30:58,569 THE GREENISH COLOR. THIS IS 3801 03:30:58,569 --> 03:31:01,272 BASED ON CITATIONS. OTHER 3802 03:31:01,272 --> 03:31:03,975 FACTORS OF DEMENTIA AND 3803 03:31:03,975 --> 03:31:05,877 SOMEWHERE IN HERE DEMENTIA AND 3804 03:31:05,877 --> 03:31:08,513 ALS. THOSE ARE MAJOR AREAS. 3805 03:31:08,513 --> 03:31:10,014 SPECIFIC GENES THAT COME ON ARE 3806 03:31:10,014 --> 03:31:12,283 IN THAT CLOUD. ON THE RIGHT HAND 3807 03:31:12,283 --> 03:31:15,186 HERE AND THERE SORT OF PINK 3808 03:31:15,186 --> 03:31:17,321 COLOR ARE THE MATHEMATICAL 3809 03:31:17,321 --> 03:31:21,159 APPROACHES. WE USE A LOT OF GENE 3810 03:31:21,159 --> 03:31:22,260 IDENTIFICATION STRATEGIES AND 3811 03:31:22,260 --> 03:31:25,163 GENE STUDY, WHICH I WILL TALK 3812 03:31:25,163 --> 03:31:26,531 ABOUT. PARTICULARLY I THINK IN 3813 03:31:26,531 --> 03:31:34,338 THE LAST TEN YEARS WE HAVE MOVED 3814 03:31:34,338 --> 03:31:36,908 AWAY FROM MALL APPROACHES, WHICH 3815 03:31:36,908 --> 03:31:38,543 ARE POWERFUL. AGAIN THIS IS 3816 03:31:38,543 --> 03:31:41,045 SOMETHING WE HAVE DISCUSSED IN 3817 03:31:41,045 --> 03:31:43,981 THIS MEETING, HOW USEFUL TO 3818 03:31:43,981 --> 03:31:47,685 IMPROVE COHORT SCIENCE. NEXT 3819 03:31:47,685 --> 03:31:51,022 SLIDE. I THINK LIKE EVERYONE ON 3820 03:31:51,022 --> 03:31:53,524 THIS CALL TODAY, NONE OF THIS 3821 03:31:53,524 --> 03:31:57,428 SITS IN A VACUUM. THIS IS JUST 3822 03:31:57,428 --> 03:31:59,463 SMATTERING OF HIGH-IMPACT 3823 03:31:59,463 --> 03:32:02,800 PAPERS. VIRTUALLY ALL ARE A 3824 03:32:02,800 --> 03:32:03,968 CONSORTIUM PAPER OR 3825 03:32:03,968 --> 03:32:07,638 COLLABORATIVE WITH OTHER 3826 03:32:07,638 --> 03:32:12,877 CENTERS. THAT IS DRIVEN THAT THE 3827 03:32:12,877 --> 03:32:15,079 STUDIES ARE DRIVEN BY SO MANY 3828 03:32:15,079 --> 03:32:17,315 PARTICIPANTS IT IS ALMOST 3829 03:32:17,315 --> 03:32:18,716 IMPOSSIBLE FROM A SINGLE CENTER. 3830 03:32:18,716 --> 03:32:22,119 WE HAVE DONE IT IN CONTEXT OF A 3831 03:32:22,119 --> 03:32:25,223 COLLABORATIVE EFFORTS. NEXT 3832 03:32:25,223 --> 03:32:32,930 SLIDE. SO HERE IS A VI 3833 03:32:32,930 --> 03:32:33,998 VISUALIZATION. WE HAVE STRONG 3834 03:32:33,998 --> 03:32:36,467 LINKS THE SORT OF THREE, FOUR 3835 03:32:36,467 --> 03:32:38,636 BIG CENTERS, BUT IN ESSENCE ALL 3836 03:32:38,636 --> 03:32:41,472 SORT OF GO ACROSS THE GLOBE. 3837 03:32:41,472 --> 03:32:43,708 COME TO THAT IN THE SECOND HALF. 3838 03:32:43,708 --> 03:32:45,710 REALLY ABOUT OUR OWN 3839 03:32:45,710 --> 03:32:48,446 SELF-DIRECTED EFFORTS TO GET 3840 03:32:48,446 --> 03:32:50,681 OUTSIDE OF OUR WELL ESTABLISHED 3841 03:32:50,681 --> 03:32:54,885 COLLABORATIVE NETWORK. NEXT 3842 03:32:54,885 --> 03:32:56,354 SLIDE. I'M VERY PROUD TO SAY, I 3843 03:32:56,354 --> 03:32:59,790 KNOW LUIGI HAS SAME STANDARDS 3844 03:32:59,790 --> 03:33:01,692 FOR THE INTRAMURAL PROGRAM WE 3845 03:33:01,692 --> 03:33:03,995 HAVE MAINTAINED PRODUCTIVITY 3846 03:33:03,995 --> 03:33:06,197 OVER THAT 22 YEARS. I DON'T KNOW 3847 03:33:06,197 --> 03:33:08,866 HOW CRITICAL THE NUMBERS ARE. I 3848 03:33:08,866 --> 03:33:10,568 THINK MANY LARGE CENTERS WOULD 3849 03:33:10,568 --> 03:33:21,145 HAVE SIMILAR MEASURES. THE ONE 3850 03:33:21,145 --> 03:33:22,446 THING I WANT TO HIGHLIGHT IS 3851 03:33:22,446 --> 03:33:24,482 WHERE WE PUBLISH. CLINICAL AND 3852 03:33:24,482 --> 03:33:26,217 NEUROLOGY ARE THE SUBJECTS WE 3853 03:33:26,217 --> 03:33:30,421 HAVE HIT THE MOST BUT ALSO THERE 3854 03:33:30,421 --> 03:33:32,556 ARE PUBLICATIONS ARE HIGHLY 3855 03:33:32,556 --> 03:33:35,159 RESPECTED AND CITED. ABOUT 20% 3856 03:33:35,159 --> 03:33:36,927 OF OUR MAYBE FROM LITTLE BIT 3857 03:33:36,927 --> 03:33:39,363 MORE OF OUR PUBLICATIONS ARE IN 3858 03:33:39,363 --> 03:33:49,907 TOP TEN CITATIONS, WHICH IS NOT 3859 03:33:51,976 --> 03:33:53,177 EGOTISTICAL BUT SHOWING WE HAVE 3860 03:33:53,177 --> 03:33:55,346 HAD AN IMPACT AND IDEAS WE HAVE 3861 03:33:55,346 --> 03:33:57,915 BUILT ON. NEXT SLIDE. THEN, YOU 3862 03:33:57,915 --> 03:34:01,619 KNOW, A LOT OF WHAT I'M TALKING 3863 03:34:01,619 --> 03:34:04,789 ABOUT IS PI DRIVEN BUT A LOT OF 3864 03:34:04,789 --> 03:34:15,333 WORK IS DONE BY TRAINEES WE GET 3865 03:34:19,303 --> 03:34:22,973 IN THE INTRAMURAL PROGRAM AND WE 3866 03:34:22,973 --> 03:34:24,942 ARE PROUD OF TRAINEES AND THEY 3867 03:34:24,942 --> 03:34:35,486 DO VERY WELL. THAT WAS A VERY 3868 03:34:35,486 --> 03:34:39,757 BRIEF SUMMARY AT THE LAB. 3869 03:34:39,757 --> 03:34:45,429 LEANING ON OUR PRIOR HISTORY AND 3870 03:34:45,429 --> 03:34:46,597 PRODUCTIVITY. WHAT I PRESENTED 3871 03:34:46,597 --> 03:34:48,699 WAS FUTURE DIRECTIONS. THIS IS 3872 03:34:48,699 --> 03:34:51,302 LITERALLY THE SLIDE I PUT UP. AT 3873 03:34:51,302 --> 03:34:54,305 THE TIME THERE WERE FOUR AREAS 3874 03:34:54,305 --> 03:34:56,674 WE FELT WERE IMPORTANT. ONE WAS 3875 03:34:56,674 --> 03:35:00,044 -- AGAIN, THIS HAS COME UP 3876 03:35:00,044 --> 03:35:03,080 SEVERAL TIMES TODAY. I THINK WE 3877 03:35:03,080 --> 03:35:04,982 ALL RECOGNIZE THE ASPECT OF 3878 03:35:04,982 --> 03:35:08,319 SCIENCE HAS BEEN FOCUSED ON 3879 03:35:08,319 --> 03:35:08,953 EUROPE PANDEMIC NORTH AMERICA 3880 03:35:08,953 --> 03:35:13,457 ANCESTRY POPULATIONS. SO WE 3881 03:35:13,457 --> 03:35:14,925 REALLY WANTED TO PUT LOT OF 3882 03:35:14,925 --> 03:35:16,694 EFFORT INTO GOING OUTSIDE THAT. 3883 03:35:16,694 --> 03:35:21,332 I WILL TALK ABOUT THAT IN THE 3884 03:35:21,332 --> 03:35:23,134 NEXT FEW SLIDES. WE ALSO 3885 03:35:23,134 --> 03:35:24,635 RECOGNIZE THOUGH WE HAVE DONE 3886 03:35:24,635 --> 03:35:27,772 WELL WITH ONE-TO-ONE GENETIC 3887 03:35:27,772 --> 03:35:31,342 RELATIONSHIPS, SINGLE GENE OR 3888 03:35:31,342 --> 03:35:39,049 COMPLEX GENETICS INTO SINGLE 3889 03:35:39,049 --> 03:35:39,383 FI 3890 03:35:39,383 --> 03:35:40,184 PHENOTYPES, THE UNDERLIE ING IS 3891 03:35:40,184 --> 03:35:43,421 MORE COMPLEX. WE ARE LOOKING AT 3892 03:35:43,421 --> 03:35:48,192 CROSSDISORDERS. LUIGI MENTIONED 3893 03:35:48,192 --> 03:35:50,194 MOVE INTO CELLULAR MODELS. I 3894 03:35:50,194 --> 03:35:52,663 WILL SHOW YOU THAT IN A SECOND. 3895 03:35:52,663 --> 03:35:54,265 I THINK THEY FOUND DEVELOPMENT 3896 03:35:54,265 --> 03:35:56,700 OF ISPC MODELS BUT PARTICULARLY 3897 03:35:56,700 --> 03:36:02,907 IN CONJUNCTION WITH CRISPR KAS 1 3898 03:36:02,907 --> 03:36:04,809 EDITING HAS MAKE EN SOMETHING 3899 03:36:04,809 --> 03:36:08,746 THAT WAS BE SPOKE TO SOMETHING 3900 03:36:08,746 --> 03:36:11,382 SCALEABLE. I SPOCK TO MOVE THE 3901 03:36:11,382 --> 03:36:13,317 SCALE OF SCALABILITY. AT THE 3902 03:36:13,317 --> 03:36:16,320 SAME TIME THE LAB USES INDIVA. 3903 03:36:16,320 --> 03:36:19,790 WE HEARD THIS FROM THE TALK ON 3904 03:36:19,790 --> 03:36:21,192 DOWN'S SYNDROME. MOUSE MODEL S 3905 03:36:21,192 --> 03:36:24,595 HAVE PRO 'S AND CONS. ONE OF THE 3906 03:36:24,595 --> 03:36:27,765 THINGS THAT'S BECOME FEASIBLE IS 3907 03:36:27,765 --> 03:36:37,107 FOCUS ON ANDROGE --AND 3908 03:36:37,107 --> 03:36:43,280 ANDOGENOUS MODELS. I WILL END 3909 03:36:43,280 --> 03:36:45,349 WITH A LITTLE TRANSLATIONAL 3910 03:36:45,349 --> 03:36:47,418 EFFORTS. WE ARE NOT A FULL LAB 3911 03:36:47,418 --> 03:36:49,787 BUT AIM TO HAVE TRANSLATIONAL SO 3912 03:36:49,787 --> 03:36:54,758 I WILL SHOW YOU A COUPLE 3913 03:36:54,758 --> 03:37:04,535 EXAMPLES. NEXT SLIDE. IT IS A 3914 03:37:04,535 --> 03:37:06,403 TRUISM IN HUE MAP GENETIC 3915 03:37:06,403 --> 03:37:08,973 STUDIES LIKE MOST ASPECTS OF 3916 03:37:08,973 --> 03:37:10,774 SCIENCE WE HAVEN'T DONE WELL IN 3917 03:37:10,774 --> 03:37:11,408 REPRESENTATION. THIS WAS 3918 03:37:11,408 --> 03:37:15,212 PUBLISHED LAST YEAR. THE FIRST 3919 03:37:15,212 --> 03:37:19,717 GENE STUDY IN PEOPLE FROM AFRICA 3920 03:37:19,717 --> 03:37:24,221 IN CONTEXT OF PARKINSON'S. A 3921 03:37:24,221 --> 03:37:30,961 RELATIVELY LARK STUDY. VE 3922 03:37:30,961 --> 03:37:33,864 CONTROLLED BUT LARGELY FROM WEST 3923 03:37:33,864 --> 03:37:36,634 AFRICA, NIGERIA IN PARTICULAR. 3924 03:37:36,634 --> 03:37:39,036 RECENT AFRICAN ANCESTRY WITHIN 3925 03:37:39,036 --> 03:37:41,272 THE U.S. THAT LED, THOUGH THE 3926 03:37:41,272 --> 03:37:44,041 NUMBER OF CASES SMALL TO SINGLE 3927 03:37:44,041 --> 03:37:47,044 GENOME LOCKER OF GBA1. MANY OF 3928 03:37:47,044 --> 03:37:49,113 YOU WILL KNOW THAT'S BEEN 3929 03:37:49,113 --> 03:37:51,882 PREVIOUSLY ASSOCIATED AS RISK 3930 03:37:51,882 --> 03:37:52,950 FACTOR IN EUROPEAN POLL 3931 03:37:52,950 --> 03:37:54,184 ALLEGATIONS BUT THIS IS THE 3932 03:37:54,184 --> 03:37:57,054 FIRST BONA FIDE RISK FACTOR IN 3933 03:37:57,054 --> 03:37:59,356 WEST AFRICA AND RECENT 3934 03:37:59,356 --> 03:38:00,891 POPULATIONS. WAS INTERLY 3935 03:38:00,891 --> 03:38:03,761 INTERESTING IS OTHER POPULATIONS 3936 03:38:03,761 --> 03:38:10,568 IT IS NOT O HOMEZYGOUS FOR 3937 03:38:10,568 --> 03:38:14,071 DOSHAYS DISEASE. IT IS A NOVEL 3938 03:38:14,071 --> 03:38:16,240 MECHANISM. NONE OF THIS HAPPENS 3939 03:38:16,240 --> 03:38:18,342 BY GOING IN AND TAKING THINGS 3940 03:38:18,342 --> 03:38:21,879 BUT BY BUILDING UP CAPACITY. 3941 03:38:21,879 --> 03:38:23,881 ACTUALLY THE SENIOR FROM THIS 3942 03:38:23,881 --> 03:38:26,884 PAPER IS NOT OUR LAB BUT FROM 3943 03:38:26,884 --> 03:38:30,254 NIGERIA. THIS IS VERY MUCH 3944 03:38:30,254 --> 03:38:31,622 PROJECTS AIMED AT PEOPLE 3945 03:38:31,622 --> 03:38:33,490 MAINTAINING DATA SOVEREIGNTY, 3946 03:38:33,490 --> 03:38:44,034 BEING SUPPORTED IN GLOBAL EF 3947 03:38:53,544 --> 03:38:57,715 EFFORTS. MORE RECENTLY THERE WAS 3948 03:38:57,715 --> 03:39:01,285 A POWER BOOST THAT ALLOWED US TO 3949 03:39:01,285 --> 03:39:02,820 FIND 12 NOVEL THAT WOULD HAVE 3950 03:39:02,820 --> 03:39:06,724 ONLY BEEN SEEN IN EUROPEAN OR 3951 03:39:06,724 --> 03:39:09,593 EUROPEAN-AMERICAN ANCESTRY. FOR 3952 03:39:09,593 --> 03:39:12,763 US THIS IS BOTH MATTER OF 3953 03:39:12,763 --> 03:39:15,032 JUSTICE AND GLOBAL JUSTICE AND 3954 03:39:15,032 --> 03:39:16,433 SCIENTIFICALLY INFORMATIVE. WE 3955 03:39:16,433 --> 03:39:23,607 WERE ABLE TO FIND MAPS FROM 3956 03:39:23,607 --> 03:39:28,445 PRIOR POPULATIONS. INCREDIBLY 3957 03:39:28,445 --> 03:39:32,650 INFORMATIVE WORK. NEXT SLIDE. I 3958 03:39:32,650 --> 03:39:35,185 MENTIONED THIS. A LOT OF WORK IS 3959 03:39:35,185 --> 03:39:38,856 APPROPRIATELY FOCUSED ON GENETIC 3960 03:39:38,856 --> 03:39:41,925 RISK AND DISORDERS. THE 3961 03:39:41,925 --> 03:39:44,795 PATHOLOGY THAT SHOW UP IN LATER 3962 03:39:44,795 --> 03:39:46,697 AGE S IS MORE COMPLEX. THIS IS 3963 03:39:46,697 --> 03:39:52,302 AN ISSUES STUDY OF EPIGENICS 3964 03:39:52,302 --> 03:39:56,707 LOOKING AT LOTY DEMENTIA, WHERE 3965 03:39:56,707 --> 03:40:00,277 THE PHENOTYPE IS THE DISORDER 3966 03:40:00,277 --> 03:40:03,580 BUT PATHOLOGY BUT LUIBITES. IF 3967 03:40:03,580 --> 03:40:07,384 YOU LOOK AT THIS SORT OF 3968 03:40:07,384 --> 03:40:08,485 RELATIVELY SMALL, WHAT YOU SEE 3969 03:40:08,485 --> 03:40:12,823 IS MIXTURE OF WHAT WE PREVIOUSLY 3970 03:40:12,823 --> 03:40:18,162 CALLED PARKINSONS OR ALILS AND 3971 03:40:18,162 --> 03:40:20,330 ALZHEIMER'S AND DEMENTIA. IN 3972 03:40:20,330 --> 03:40:21,965 FACT, AT LEAST THIS LEVEL IS 3973 03:40:21,965 --> 03:40:26,336 PRETTY EVEN MIX OF BOTH. 3974 03:40:26,336 --> 03:40:29,973 DOMINATING THE GENOMIC 3975 03:40:29,973 --> 03:40:36,346 LANDSCAPE. THAT REALLY TELLS YOU 3976 03:40:36,346 --> 03:40:38,549 IN A WAY THAT SUPPORTS THIS, 3977 03:40:38,549 --> 03:40:42,820 MANY OF THESE HAVE COMPLEX 3978 03:40:42,820 --> 03:40:51,562 GENETIC AND OVER LAPS. NEXT 3979 03:40:51,562 --> 03:40:52,696 SLIDE. THAT IS PROBABLY 3980 03:40:52,696 --> 03:40:55,466 UNDERESTIMATE. WHAT WE HAVE 3981 03:40:55,466 --> 03:41:00,771 LOOKED AT ARE VARIANTS, ALILS, 3982 03:41:00,771 --> 03:41:02,906 THE SO-CALLED SNIPS. WE KNOW 3983 03:41:02,906 --> 03:41:06,376 THERE IS A LOT OF SO-CALLED 3984 03:41:06,376 --> 03:41:09,146 HIDDEN VARIATION AROUND 3985 03:41:09,146 --> 03:41:11,281 STRUCTURAL VARIATION SO 3986 03:41:11,281 --> 03:41:18,722 INSERTIONS, DELL ELECTROCU -- D 3987 03:41:18,722 --> 03:41:21,558 AND VARIOUS THINGS. OTHERS 3988 03:41:21,558 --> 03:41:25,763 LOOKED FOR OTHER VARIOUS BODIES 3989 03:41:25,763 --> 03:41:31,135 AND FOUND NOVEL AROUND TCPM1 3990 03:41:31,135 --> 03:41:34,438 VALIDATING THE COHORTS FOR THE 3991 03:41:34,438 --> 03:41:36,306 LUDY BODY DEMENTIA. MY FEELING 3992 03:41:36,306 --> 03:41:40,644 IS WE WILL SEE INCREASING NUMBER 3993 03:41:40,644 --> 03:41:46,150 OF THESE TYPES FACILITATED BY 3994 03:41:46,150 --> 03:41:47,251 LONG RANGE SEQUENCING, SOMETHING 3995 03:41:47,251 --> 03:41:49,153 UP AND RUNNING IN THE LAB. AS 3996 03:41:49,153 --> 03:41:51,722 MANY OF YOU KNOW PRIOR STUDIES 3997 03:41:51,722 --> 03:41:55,726 USING GENOME STUDIES HAVE 3998 03:41:55,726 --> 03:42:06,270 FOCUSED ON ACCESSIBLE AND OTHER 3999 03:42:12,209 --> 03:42:14,311 INFORMATION. ONTO MORE OF THE 4000 03:42:14,311 --> 03:42:18,415 FUNCTIONAL WORK, AS LUIGI SAID, 4001 03:42:18,415 --> 03:42:22,152 THIS IS WHAT I'M INTERESTED IN. 4002 03:42:22,152 --> 03:42:24,388 THE CHALLENGE HAS BEEN TO TAKE 4003 03:42:24,388 --> 03:42:29,626 THAT RICH INFORMATION FROM 4004 03:42:29,626 --> 03:42:31,762 GENETICS AND TRANSLATE IT. AS I 4005 03:42:31,762 --> 03:42:34,464 MENTIONED THE DEVELOPMENT OF 4006 03:42:34,464 --> 03:42:35,799 ROBUST ATTITUDE IS MADE THAT 4007 03:42:35,799 --> 03:42:38,402 VERY SCALEABLE. THIS IS A 4008 03:42:38,402 --> 03:42:40,904 PROJECT I CO -LEAD AND 4009 03:42:40,904 --> 03:42:45,609 INVESTIGATOR AT NDS. I WILL 4010 03:42:45,609 --> 03:42:46,643 EMPHASIZE THE COLLABORATIVE 4011 03:42:46,643 --> 03:42:48,512 NATURE OF THE LAB. WHERE WE 4012 03:42:48,512 --> 03:42:54,318 DEVELOP WHAT WE CALL THE IPSC 4013 03:42:54,318 --> 03:43:04,494 INITIA 4014 03:43:08,298 --> 03:43:11,635 INITIATIVE. IF ALILLS ARE 4015 03:43:11,635 --> 03:43:15,539 ASSOCIATED WITH MULTIPLE 4016 03:43:15,539 --> 03:43:18,742 DISEASE, I WILL COME BACK, IF 4017 03:43:18,742 --> 03:43:20,878 THEY CAN SHOW MULTIPLE 4018 03:43:20,878 --> 03:43:22,946 PHENOTYPES WE SHOULD LOOK ACROSS 4019 03:43:22,946 --> 03:43:26,984 CONSISTENT BACKGROUNDS. SO THIS 4020 03:43:26,984 --> 03:43:29,119 IS AS MUCH ENGINEERING AS 4021 03:43:29,119 --> 03:43:30,821 SCIENCE PROJECT. I'M PLEASED TO 4022 03:43:30,821 --> 03:43:34,358 SAY WE HAVE SUPPORT FROM CARD 4023 03:43:34,358 --> 03:43:36,793 AND FROM TRANS BERGEN AND 4024 03:43:36,793 --> 03:43:39,830 PARKINSON'S FOCUSED GROUP TO 4025 03:43:39,830 --> 03:43:42,099 EXPAND THAT SIDE OF OF ADRD. 4026 03:43:42,099 --> 03:43:45,202 WHERE THIS IS, IF YOU WISH YOU 4027 03:43:45,202 --> 03:43:48,839 CAN GO TO JACK'S WOOILT WEBSITE, 4028 03:43:48,839 --> 03:43:50,374 WHERE YOU ORDER MICE AND ORDER 4029 03:43:50,374 --> 03:43:57,814 THIS SERIES NOT ONLY ALILS OF 4030 03:43:57,814 --> 03:44:03,553 INTEREST SO YOU KNOW WHAT YOU 4031 03:44:03,553 --> 03:44:03,887 A 4032 03:44:03,887 --> 03:44:07,057 ARE GETTING. WE HAVE SHIFTED TO 4033 03:44:07,057 --> 03:44:09,826 3200 LINES. IN PARALLEL THE MIX 4034 03:44:09,826 --> 03:44:17,601 IS STILL IN DEVELOPMENT WITH 4035 03:44:17,601 --> 03:44:19,002 THIS SO I APPRECIATE THE 4036 03:44:19,002 --> 03:44:20,470 AVAILABILITY. THOSE DATA SETS 4037 03:44:20,470 --> 03:44:31,014 WILL BE GENERATED AND AVAILABLE. 4038 03:44:31,014 --> 03:44:33,383 SOMETHING I LIST, THE FIRST TIME 4039 03:44:33,383 --> 03:44:35,419 THIS HAS BEEN ANNOUNCED, THEY 4040 03:44:35,419 --> 03:44:37,854 WERE ACTUALLY SETTING UP FOR 4041 03:44:37,854 --> 03:44:39,790 JUNIOR EARLY CAREER RESEARCHERS 4042 03:44:39,790 --> 03:44:41,792 IN WORKSHOPS TO RELAY A LOT OF 4043 03:44:41,792 --> 03:44:43,760 THIS INFORMATION ABOUT HOW YOU 4044 03:44:43,760 --> 03:44:48,665 EPG NEAR AND MANIPULATE IPSC. 4045 03:44:48,665 --> 03:44:51,468 NEXT MAY THESE WILL BE SHARED. 4046 03:44:51,468 --> 03:44:55,372 SYMPOSIUM AND IN-PERSON WORKSHOP 4047 03:44:55,372 --> 03:45:00,377 WORKING WITH JACKSON LAB. IF YOU 4048 03:45:00,377 --> 03:45:02,179 ARE TRAINEES LET ME KNOW. WE 4049 03:45:02,179 --> 03:45:06,049 HAVE A FEW SPOTS FILLING UP 4050 03:45:06,049 --> 03:45:11,388 FAST. JUST AN EXAMPLE BEYOND 4051 03:45:11,388 --> 03:45:13,757 WHAT WE DO AND MORE INTO 4052 03:45:13,757 --> 03:45:15,993 ENGAGEMENT IN THE PROPER 4053 03:45:15,993 --> 03:45:17,694 COMMUNITY. NEXT SLIDE. THE LAST 4054 03:45:17,694 --> 03:45:19,763 SORT OF IN THE CELL MODELLING IS 4055 03:45:19,763 --> 03:45:23,367 OF COURSE WHAT I TALKED ABOUT SO 4056 03:45:23,367 --> 03:45:25,469 FAR FROM VARIANTS, WHICH WE 4057 03:45:25,469 --> 03:45:28,205 EXPECT TO HAVE HIGHER EFFECTS IN 4058 03:45:28,205 --> 03:45:33,443 CELLS BECAUSE SHOULD HAVE 4059 03:45:33,443 --> 03:45:34,344 STROPSTR 4060 03:45:34,344 --> 03:45:36,847 STRONGER APPROXIMATE. ONE OF THE 4061 03:45:36,847 --> 03:45:38,582 CHALLENGES IS CODING VARIANTS OF 4062 03:45:38,582 --> 03:45:42,652 HIGH VALUE TO NON-CODING 4063 03:45:42,652 --> 03:45:44,788 VARIANTS. SO JUST VERY BRIEFLY 4064 03:45:44,788 --> 03:45:48,225 AS PUBLICATION FROM TWO YEARS 4065 03:45:48,225 --> 03:45:50,227 AGO TRANSLATION MATSON WHERE WE 4066 03:45:50,227 --> 03:45:52,529 DID THIS LOOKING ABOVE HUMAN 4067 03:45:52,529 --> 03:45:56,099 BRAIN AND IPSCs. IN THIS CASE 4068 03:45:56,099 --> 03:45:58,468 THE INFLAMMATORY CELLS OF THE 4069 03:45:58,468 --> 03:46:01,238 BRAIN. REALLY KEY TO THIS WAS 4070 03:46:01,238 --> 03:46:04,007 HOW POPULATION LEVEL IPSCs WHERE 4071 03:46:04,007 --> 03:46:07,010 WE HAVE THE SAME VARIANTS AND WE 4072 03:46:07,010 --> 03:46:09,413 COULD CITE -- REALLY DRIVE THE 4073 03:46:09,413 --> 03:46:12,115 STUDY BY LOOKING AT VARIANTS 4074 03:46:12,115 --> 03:46:14,184 ASSOCIATED WITH DISEASE BOTH IN 4075 03:46:14,184 --> 03:46:19,256 HUMANS AND IPSCs. THE MESSAGE IS 4076 03:46:19,256 --> 03:46:22,592 WE FEEL THIS IS PREDOMINANTLY 4077 03:46:22,592 --> 03:46:28,498 WORKING THROUGH A MICRO ALIL 4078 03:46:28,498 --> 03:46:32,069 STATE. AT THE SAME TIME IPSCs 4079 03:46:32,069 --> 03:46:37,507 ARE GOOD. GOOD FOR LOOKING AT 4080 03:46:37,507 --> 03:46:40,744 ANDOGENOUS GENETICS BUT IN TACK 4081 03:46:40,744 --> 03:46:43,313 SYSTEMS WITH COMPLEXITY CNS HAS. 4082 03:46:43,313 --> 03:46:47,517 MIGHT BE COMPLICATED TO LOOK AT 4083 03:46:47,517 --> 03:46:53,457 THINGS LIKE AGING. HERE IS AN 4084 03:46:53,457 --> 03:46:55,759 EXAMPLE. A SERIES OF SMALL 4085 03:46:55,759 --> 03:47:00,130 FAMILIES WITH RECESSIVE 4086 03:47:00,130 --> 03:47:05,135 INHERITANCE. WITH DEFECT IN 4087 03:47:05,135 --> 03:47:06,570 SYNTHESIS. WHAT BEN'S GROUP WERE 4088 03:47:06,570 --> 03:47:11,374 ABLE TO DO IS SHOW WHEN THEY 4089 03:47:11,374 --> 03:47:12,609 KNOCK DOWN THE SAME GENE IN A 4090 03:47:12,609 --> 03:47:16,847 SPECIFIC MANNER YOU COULD HAVE 4091 03:47:16,847 --> 03:47:19,082 PHYSIOLOGICAL EFFECTS IN MOTOR 4092 03:47:19,082 --> 03:47:29,626 LEARNING. THIS IS WE HAVE TAKEN 4093 03:47:30,127 --> 03:47:33,864 IT BACK TO THE HUMANS. SO AGAIN, 4094 03:47:33,864 --> 03:47:40,170 I WANT YOU TO SORT OF GET THE 4095 03:47:40,170 --> 03:47:42,139 SENSE HERE OF HOW TO BUILD TOOL 4096 03:47:42,139 --> 03:47:44,741 SETS ACROSS SPECIES TO LOOK AND 4097 03:47:44,741 --> 03:47:49,913 SEE WHERE ANDOGENOUS GENES HAVE 4098 03:47:49,913 --> 03:47:59,990 EFFECT IN CELLULAR CONTEXT. THIS 4099 03:47:59,990 --> 03:48:02,759 IS FROM BEN'S WORK AGAIN. THIS 4100 03:48:02,759 --> 03:48:05,695 IS A PROTEIN WIDELY STUDIED. HAS 4101 03:48:05,695 --> 03:48:07,864 AN INTERESTING ALIEL, WHERE SOME 4102 03:48:07,864 --> 03:48:11,735 INDIVIDUALS HAVE SHOCK MARI 4103 03:48:11,735 --> 03:48:21,545 TOOTH NEW NEWER P -- NEUROPATHY 4104 03:48:21,545 --> 03:48:23,613 HE WAS ABLE TO LOOK AT THE 4105 03:48:23,613 --> 03:48:27,217 EFFECTS OF THIS IN DOPAMINE 4106 03:48:27,217 --> 03:48:31,488 NEURONS AND SHOW THEY HAVE AL 4107 03:48:31,488 --> 03:48:35,325 STRESS. SO THE POINT, JUST 4108 03:48:35,325 --> 03:48:37,127 VIGNETTES, REALLY, IS HOR 4109 03:48:37,127 --> 03:48:40,530 IMPORTANT IT IS TO MOVE FROM 4110 03:48:40,530 --> 03:48:42,832 CONTEXT OF SINGLE GENES AND 4111 03:48:42,832 --> 03:48:45,235 ALIELS INTO PHYSIOLOGICAL 4112 03:48:45,235 --> 03:48:49,673 CONTEXT TO SEIZE OUT EFFECTS ON 4113 03:48:49,673 --> 03:48:54,511 DIFFERENT CELL TYPES. SO LAST 4114 03:48:54,511 --> 03:48:58,815 TWO THINGS, NOT A FULLY 4115 03:48:58,815 --> 03:49:01,117 TRANSITIONAL LAB. THIS WAS LED 4116 03:49:01,117 --> 03:49:02,886 BY -- WE MEET EARLIER, MANY OF 4117 03:49:02,886 --> 03:49:04,788 YOU WILL KNOW. LOOKING AT 4118 03:49:04,788 --> 03:49:15,298 SPECIFIC P38 HE'S SHOWN HAS 4119 03:49:15,498 --> 03:49:17,534 INFLAMMATION AND SHOW CAN 4120 03:49:17,534 --> 03:49:21,071 IMPROVE IN IPSC. SOME MODELS, 4121 03:49:21,071 --> 03:49:23,607 MOUSE MODELS, MULTIPLE MEASURES 4122 03:49:23,607 --> 03:49:26,309 INCLUDING NEUROINFLAMMATORY 4123 03:49:26,309 --> 03:49:30,080 SIGNALLING. THIS IS ONE OF THOSE 4124 03:49:30,080 --> 03:49:37,420 CURRENTLY FORWARD TO CLINICAL 4125 03:49:37,420 --> 03:49:39,789 TRIALS. NEXT SLIDE. I THINK LIKE 4126 03:49:39,789 --> 03:49:45,962 A LOT, WE ARE ALWAYS KEEN TO GO 4127 03:49:45,962 --> 03:49:48,465 PATIENTS, BRIAN TO THE PHD, 4128 03:49:48,465 --> 03:49:53,903 DISCOVER OF 72, WHICH IS AN ALS 4129 03:49:53,903 --> 03:49:56,640 SPECTRUM GENE, BRIAN HAS A LONG 4130 03:49:56,640 --> 03:49:59,509 INTEREST IN NATURAL HISTORY. 4131 03:49:59,509 --> 03:50:02,279 RECENTLY JOINED IN ALL ACROSS 4132 03:50:02,279 --> 03:50:06,983 DIFFERENT DIFFERENT GENETIC TD. 4133 03:50:06,983 --> 03:50:10,020 TWO THINGS. FIRST OF ALL NATURAL 4134 03:50:10,020 --> 03:50:13,890 HISTORY AND BIOMARKER, CRITICAL. 4135 03:50:13,890 --> 03:50:15,659 MOVING FORWARD TO GENE OR TYPES 4136 03:50:15,659 --> 03:50:17,560 OF THERAPY. BRIAN HAS AN 4137 03:50:17,560 --> 03:50:19,663 INITIATIVE WITH NATIONAL CENTER 4138 03:50:19,663 --> 03:50:23,166 FOR ADVANCED TRANSLATIONAL 4139 03:50:23,166 --> 03:50:28,938 SCIENCES TO LOOK AT THE 4140 03:50:28,938 --> 03:50:30,440 NUCLEOTIDES, ESPECIALLY IN THE 4141 03:50:30,440 --> 03:50:32,709 CONTEXT OF THESE DISEASES. 4142 03:50:32,709 --> 03:50:34,010 REALLY AGAIN SORT OF BRINGING 4143 03:50:34,010 --> 03:50:36,980 THIS FROM GENETICS THROUGH THE 4144 03:50:36,980 --> 03:50:38,815 MODELLING, BACK TO THE PATIENTS. 4145 03:50:38,815 --> 03:50:42,118 AT LEAST WHERE THAT IS 4146 03:50:42,118 --> 03:50:48,925 APPROPRIATE. LAST SLIDE. WE ARE 4147 03:50:48,925 --> 03:50:52,495 BEEN AT IRP THE LAST 20 YEAR, 4148 03:50:52,495 --> 03:50:53,730 HAVE LOT OF PRODUCTIVITY. 4149 03:50:53,730 --> 03:50:55,332 CURRENT EFFORTS WERE EXPANDING 4150 03:50:55,332 --> 03:50:57,100 THAT OUT HOW WE LOOK IN THE 4151 03:50:57,100 --> 03:50:58,635 PAST. NOT ONLY PRODUCTIVE BUT 4152 03:50:58,635 --> 03:51:00,303 ALSO IMPORTANT. I THINK WE ARE 4153 03:51:00,303 --> 03:51:02,105 LEARNING A LOT FROM GENETICS AND 4154 03:51:02,105 --> 03:51:06,242 MOVING THAT TO MODELS. HOPEFULLY 4155 03:51:06,242 --> 03:51:08,311 BRING SOME BACK TO PATIENTS. SO 4156 03:51:08,311 --> 03:51:10,347 THANKS FOR YOUR TIME. REALLY 4157 03:51:10,347 --> 03:51:11,314 APPRECIATE THE OPPORTUNITY TO 4158 03:51:11,314 --> 03:51:12,782 SPEAK. HAPPY TO TAKE QUESTION , 4159 03:51:12,782 --> 03:51:23,326 IF THERE ARE ANY, THANKS. THANK 4160 03:51:26,262 --> 03:51:27,130 YOU, OUTSTANDING. 4161 03:51:27,130 --> 03:51:29,032 >> THANK YOU FOR THE GREAT 4162 03:51:29,032 --> 03:51:33,236 OVERVIEW OF LABORATORY GENETICS. 4163 03:51:33,236 --> 03:51:43,680 QUESTIONS FROM OUR -- NOT 4164 03:51:45,382 --> 03:51:47,384 HEARING ANY. MARK, THANK YOU. 4165 03:51:47,384 --> 03:51:49,986 OPINION APPRECIATE YOUR 4166 03:51:49,986 --> 03:51:53,790 PRESENTATION. SO AT THIS POINT 4167 03:51:53,790 --> 03:51:56,326 IN THE -- OUR DAY TWO THIS WILL 4168 03:51:56,326 --> 03:51:59,562 BE THE CONCLUSION OF OUR 151ST 4169 03:51:59,562 --> 03:52:02,932 MEETING OF THE NATIONAL ADVISORY 4170 03:52:02,932 --> 03:52:05,435 COUNCIL ON AGING OF THIS OPEN 4171 03:52:05,435 --> 03:52:07,237 SESSION. SO AT THIS POINT WE 4172 03:52:07,237 --> 03:52:10,607 WILL BE CONCLUDING THE OPEN 4173 03:52:10,607 --> 03:52:14,210 SESSION. I ASK THAT ALL 4174 03:52:14,210 --> 03:52:16,880 COUNCILMEMBERS AND THE DIVISION 4175 03:52:16,880 --> 03:52:18,181 DIRECTORS FOR NIH PLEASE STAY 4176 03:52:18,181 --> 03:52:20,717 ON. WE WILL HAVE A SHORT CLOSED 4177 03:52:20,717 --> 03:52:24,354 SESSION WITH LUIGI. THEN WE WILL 4178 03:52:24,354 --> 03:52:27,791 CONCLUDE THE MEETING OVERALL. SO 4179 03:52:27,791 --> 03:52:30,460 THANK YOU AGAIN, EVERYONE. WE 4180 03:52:30,460 --> 03:52:31,795 WILL START AGAIN IN JUST A 4181 03:52:31,795 --> 03:52:32,028 MINUTE. 4182 03:52:32,028 --> 03:52:35,365 4183 03:52:35,365 --> 03:52:37,734 >> THANK YOU KEN. I WILL 4184 03:52:37,734 --> 03:52:39,102 SHARE MY SLIDES WITH YOU IN A 4185 03:52:39,102 --> 03:52:40,236 COUPLE MINUTES WHEN YOU TELL ME 4186 03:52:40,236 --> 03:52:40,970 TO DO IT. 4187 03:52:40,970 --> 03:52:44,340 >> OKAY, GREAT. 4188 03:52:44,340 --> 03:52:44,607 4189 03:52:44,607 --> 03:52:47,143 >> MAKING SURE THAT EVERYBODY 4190 03:52:47,143 --> 03:52:51,147 ELSE SIGNS OFF. EVEN JASMINE, 4191 03:52:51,147 --> 03:52:56,119 MYSELF AND TEL ZOOM PEOPLE WILL 4192 03:52:56,119 --> 03:52:58,755 BE GONE. KEN, YOU WILL BE THE 4193 03:52:58,755 --> 03:53:00,290 HOST. WHEN APPROPRIATE, END THE 4194 03:53:00,290 --> 03:53:02,158 MEETING AFTER THAT. 4195 03:53:02,158 --> 03:53:02,592 >> THANK YOU. 4196 03:53:02,592 --> 03:53:02,759 4197 03:53:02,759 --> 03:53:02,859