1 00:00:05,538 --> 00:00:06,005 IT'S A PLEASURE TO 2 00:00:06,072 --> 00:00:06,272 >> THANK YOU. 3 00:00:06,339 --> 00:00:07,640 IT'S A PLEASURE TO SEE YOUR 4 00:00:07,707 --> 00:00:09,175 BRIGHT SHINING FACES. 5 00:00:09,242 --> 00:00:16,282 MY NAME IS MELISSA PARISI AND I 6 00:00:16,349 --> 00:00:18,118 LEAD THE NIH INCLUDE PROJECT AND 7 00:00:18,184 --> 00:00:20,387 WE HAD OVER 270 WHO REGISTERED 8 00:00:20,453 --> 00:00:23,656 SO WE'RE EXCITED TO HAVE YOU ALL 9 00:00:23,723 --> 00:00:25,091 HERE. 10 00:00:25,158 --> 00:00:30,397 I THOUGHT I'D GET AUDIENCE 11 00:00:30,463 --> 00:00:34,901 PARTICIPATION FOR STARTERS. 12 00:00:34,968 --> 00:00:36,603 HOW MANY ARE HERE FOR THE FIRST 13 00:00:36,669 --> 00:00:37,036 TIME. 14 00:00:37,103 --> 00:00:38,171 WELCOME. 15 00:00:38,238 --> 00:00:42,409 IF YOU GET TO SEE THE HALL OF 16 00:00:42,475 --> 00:00:43,877 NOBEL LAUREATES IT'S GREAT IT'S 17 00:00:43,943 --> 00:00:48,415 WONDERFUL BUT BE HERE FOR THE 18 00:00:48,481 --> 00:00:48,815 SESSIONS. 19 00:00:48,882 --> 00:00:49,249 ALL RIGHT. 20 00:00:49,315 --> 00:00:50,850 I'M GOING KICK THINGS OFF FOR 21 00:00:50,917 --> 00:00:52,819 OUR FIRST SESSION AND GIVE A FEW 22 00:00:52,886 --> 00:00:55,088 HOUSEKEEPING REMARKS TO START US 23 00:00:55,155 --> 00:00:55,522 OFF. 24 00:00:55,588 --> 00:01:02,395 WE'RE GOING TO HAVE DR. DI 25 00:01:02,462 --> 00:01:06,833 DR. DIANNE -- DIANA BIANCHI AND 26 00:01:06,900 --> 00:01:08,234 WE'LL GIVE INTRODUCTION TO WHAT 27 00:01:08,301 --> 00:01:09,669 HAS BEEN GOING ON WITH THE 28 00:01:09,736 --> 00:01:10,270 INCLUDE PROJECT FOR THE PAST 29 00:01:10,336 --> 00:01:15,742 FIVE YEARS. 30 00:01:15,809 --> 00:01:17,343 I WANTS TO MAKE SURE EVERYBODY 31 00:01:17,410 --> 00:01:19,045 HAD A CHANCE DOWNLOAD THE 32 00:01:19,112 --> 00:01:21,448 SCHEDULE OR REVIEW THE SCHEDULE 33 00:01:21,514 --> 00:01:22,982 WITH YOU VERY BRIEFLY. 34 00:01:23,049 --> 00:01:25,151 THERE'S A QR CODE ON POSTERS 35 00:01:25,218 --> 00:01:26,586 OUTSIDE THE AUDITORIUM IF YOU 36 00:01:26,653 --> 00:01:28,455 WANT A MORE DETAILED VERSION OF 37 00:01:28,521 --> 00:01:28,988 THE AGENDA. 38 00:01:29,055 --> 00:01:31,224 WE'RE TRYING TO SAVE PAPER AND 39 00:01:31,291 --> 00:01:32,625 TREES SO WE DIDN'T PRINTOUT A 40 00:01:32,692 --> 00:01:33,259 LOT OF COPIES. 41 00:01:33,326 --> 00:01:35,795 FIRST, WE'LL HAVE SESSIONS. 42 00:01:35,862 --> 00:01:38,231 WE NUMBERED THESE IN ORDER. 43 00:01:38,298 --> 00:01:39,499 MANY ARE PANEL DISCUSSIONS. 44 00:01:39,566 --> 00:01:41,801 WE'RE HOPING TO HAVE FORMAL 45 00:01:41,868 --> 00:01:43,069 PRESENTATIONS FOLLOWED BY 46 00:01:43,136 --> 00:01:43,770 DISCUSSION AND Q&A. 47 00:01:43,837 --> 00:01:45,605 SO THIS IS WHERE WE'RE GOING 48 00:01:45,672 --> 00:01:50,176 NEED AUDIENCE PARTICIPATION. 49 00:01:50,243 --> 00:01:52,011 WE'LL HAVE SEVERAL BREAKS WITH 50 00:01:52,078 --> 00:01:52,846 REFRESHMENTS AVAILABLE DURING 51 00:01:52,912 --> 00:01:56,449 THE BREAKS AND IMPORTANTLY, 52 00:01:56,516 --> 00:01:58,818 LUNCH, BECAUSE WE'LL BE HUNGRY 53 00:01:58,885 --> 00:02:03,256 AND HAVE BOX LUNCHES BOTH DAYS 54 00:02:03,323 --> 00:02:04,090 START AT NOON. 55 00:02:04,157 --> 00:02:06,426 HOWEVER, LUNCHEON TOMORROW'S 56 00:02:06,493 --> 00:02:09,395 DATE WILL ALSO HAVE BREAKOUT 57 00:02:09,462 --> 00:02:09,662 SESSIONS. 58 00:02:09,729 --> 00:02:11,498 WE WANT YOU TO BE PARTICULARLY 59 00:02:11,564 --> 00:02:13,900 EFFICIENT ABOUT GETTING YOUR 60 00:02:13,967 --> 00:02:16,769 LUNCHES TO CHOOSE A BREAKOUT 61 00:02:16,836 --> 00:02:19,572 GROUP TO JOIN FOR DISCUSSION 62 00:02:19,639 --> 00:02:20,306 DURING THE LUNCH PERIOD. 63 00:02:20,373 --> 00:02:26,446 I WANT TO POINT OUT WE HAVE A 64 00:02:26,513 --> 00:02:30,683 POSTER SESSION STARTING AT 3:30 65 00:02:30,750 --> 00:02:33,052 AND WE'RE PROUD AND EXCITED BY 66 00:02:33,119 --> 00:02:35,255 THIS POSTERS THAT ARE GOING TO 67 00:02:35,321 --> 00:02:37,957 BE PRESENTED AND THERE WILL BE 68 00:02:38,024 --> 00:02:38,591 REFRESHMENTS AVAILABLE AS WELL 69 00:02:38,658 --> 00:02:40,660 AS INCENTIVE TO KEEP YOU LOOKING 70 00:02:40,727 --> 00:02:42,195 AT THE POSTERS AND TALK WITH THE 71 00:02:42,262 --> 00:02:47,734 HARD WORKING INVESTIGATORS WHO 72 00:02:47,800 --> 00:02:48,167 PREPARED THEM. 73 00:02:48,234 --> 00:02:51,738 A LITTLE BIT OF HOUSEKEEPING. 74 00:02:51,804 --> 00:02:56,142 WE'LL BE FOCUSSING ON DOWN 75 00:02:56,209 --> 00:02:56,743 SYNDROME RESEARCH AND BASIC 76 00:02:56,809 --> 00:02:59,546 CLINICAL TRIALS AND WE'LL HAVE 77 00:02:59,612 --> 00:03:04,517 TIME KEEPERS SITUATED LETTING 78 00:03:04,584 --> 00:03:06,419 YOU KNOW WHEN THERE'S THREE OR 79 00:03:06,486 --> 00:03:07,253 FIVE MINUTES LEFT. 80 00:03:07,320 --> 00:03:08,788 IF YOU HAVE QUESTIONS YOU'LL SEE 81 00:03:08,855 --> 00:03:11,491 THE TWO MICROPHONES IN THE 82 00:03:11,558 --> 00:03:12,225 AISLES. 83 00:03:12,292 --> 00:03:14,360 LINE UP BEHIND THOSE TO PROVIDE 84 00:03:14,427 --> 00:03:16,195 YOUR QUESTIONS AND/OR DISCUSSION 85 00:03:16,262 --> 00:03:16,896 ITEMS. 86 00:03:16,963 --> 00:03:27,273 I MENTIONED THE BOX LUNCHES AND 87 00:03:27,340 --> 00:03:29,175 FOOD AND WE APPRECIATE EVERYONE 88 00:03:29,242 --> 00:03:30,476 WORKING TOGETHER TO MAKE SURE IT 89 00:03:30,543 --> 00:03:31,411 WILL BE A GREAT MEETING. 90 00:03:31,477 --> 00:03:33,580 I WANTED TO HIGHLIGHT THE 91 00:03:33,646 --> 00:03:34,948 SPEAKER WHO'S ARE SELF-ADVOCATES 92 00:03:35,014 --> 00:03:36,082 WITH DOWN SYNDROME. 93 00:03:36,149 --> 00:03:40,920 THE FIRST IS MR. ISAIAH LOMBARDO 94 00:03:40,987 --> 00:03:50,029 I'LL INTRODUCE LATER AND MS. 95 00:03:50,096 --> 00:03:54,334 AGUSTA AGWARD AND MR. DAVID 96 00:03:54,400 --> 00:03:59,038 EAGAN AND HE'LL INTRODUCING 97 00:03:59,105 --> 00:04:02,408 DR. ESPINOZA TOMORROW. 98 00:04:02,475 --> 00:04:05,678 WE'RE GRATEFUL FOR OUR 99 00:04:05,745 --> 00:04:07,080 SELF-ADVOCATES WHO HAVE JOINED 100 00:04:07,146 --> 00:04:07,714 US TALKING ABOUT THE CONTINUING 101 00:04:07,780 --> 00:04:09,716 TO OF DOWN SYNDROME SO RELEVANT 102 00:04:09,782 --> 00:04:11,217 TO THEIR LIVES. 103 00:04:11,284 --> 00:04:14,487 FINALLY, I'D LIKE TO THANK OUR 104 00:04:14,554 --> 00:04:15,355 INCLUDE AMBASSADORS. 105 00:04:15,421 --> 00:04:17,523 WHEN YOU JOINED US THIS MORNING 106 00:04:17,590 --> 00:04:20,193 YOU WERE PROBABLY GREETED WITH 107 00:04:20,259 --> 00:04:22,395 PIA AND GABBY AND THEY'RE IT 108 00:04:22,462 --> 00:04:27,000 THREE AMBASSADORS WHO 109 00:04:27,066 --> 00:04:27,900 VOLUNTEERED THEIR TIME TO 110 00:04:27,967 --> 00:04:29,302 WELCOME EVERYBODY TO THE 111 00:04:29,369 --> 00:04:29,569 MEETING. 112 00:04:29,636 --> 00:04:33,573 THANK YOU VERY MUCH TO PIA, 113 00:04:33,640 --> 00:04:34,707 GABBY AND THERESA AS WELL. 114 00:04:34,774 --> 00:04:37,110 ALL RIGHT. 115 00:04:37,176 --> 00:04:39,112 SO WITHOUT FURTHER ADO, I'D LIKE 116 00:04:39,178 --> 00:04:44,250 TO INTRODUCE MY BOSS, DR. DIANA 117 00:04:44,317 --> 00:04:45,485 BIANCHI. 118 00:04:45,551 --> 00:04:48,755 SHE IS THE DIRECTOR OF THE 119 00:04:48,821 --> 00:04:49,422 EUNICE KENNEDY SHRIVER NATIONAL 120 00:04:49,489 --> 00:04:50,490 INSTITUTE OF CHILD HEALTH AND 121 00:04:50,556 --> 00:04:52,358 HUMAN DEVELOPMENT AND OVERSEES 122 00:04:52,425 --> 00:04:55,895 AN ANNUAL BUDGET OF ABOUT $1.6 123 00:04:55,962 --> 00:04:57,764 BILLION AS PART OF NICHD'S 124 00:04:57,830 --> 00:05:00,867 MISSION TO UNDERSTAND HUMAN 125 00:05:00,933 --> 00:05:03,136 DEVELOPMENT, ENHANCE THE CHILD 126 00:05:03,202 --> 00:05:05,004 OF CHILD AND ADOLESCENTS AND 127 00:05:05,071 --> 00:05:08,408 OPTIMIZE ABILITIES FOR ALL. 128 00:05:08,474 --> 00:05:13,813 DR. BIANCHI IS FOR THE CENTER OF 129 00:05:13,880 --> 00:05:15,648 PRECISION HEALTH RESEARCH WHERE 130 00:05:15,715 --> 00:05:19,352 SHE DOES RESEARCH ON PRENATAL 131 00:05:19,419 --> 00:05:20,620 THERAPIES FOR GENETIC DISORDERS 132 00:05:20,687 --> 00:05:24,590 FOR THE AUSPICES OF THE HUMAN 133 00:05:24,657 --> 00:05:25,191 GENOME INSTITUTE. 134 00:05:25,258 --> 00:05:29,295 ANOTHER INSTITUTE HERE AT NIH. 135 00:05:29,362 --> 00:05:30,997 SHE IS A MEMBER OF THE NATIONAL 136 00:05:31,064 --> 00:05:32,565 ACADEMY OF MEDICINE AND HAS A 137 00:05:32,632 --> 00:05:34,133 LONG LIST OF AWARDS AND 138 00:05:34,200 --> 00:05:34,400 ACCOLADES. 139 00:05:34,467 --> 00:05:35,535 I ENCOURAGE TO YOU GO TO THE WEB 140 00:05:35,601 --> 00:05:38,237 SATE FOR THE MEETING TO GET MORE 141 00:05:38,304 --> 00:05:41,374 DETAILS AND IMPORTANTLY CO-CHAIR 142 00:05:41,441 --> 00:05:42,942 OF THE NIH INCLUDE STEERING 143 00:05:43,009 --> 00:05:44,243 COMMITTEE WHERE SHE HELPS GUIDE 144 00:05:44,310 --> 00:05:45,344 THE INCLUDE INITIATIVE. 145 00:05:45,411 --> 00:05:55,822 DR. BIANCHI, YOU'RE UP. 146 00:05:59,125 --> 00:06:04,530 >> THANK YOU FOR THE KIND 147 00:06:04,597 --> 00:06:05,865 INTRODUCTION AND IT'S MY 148 00:06:05,932 --> 00:06:07,800 PARTICULAR TO STEER THE 149 00:06:07,867 --> 00:06:09,535 COMMITTEE WITH DR. HODES THE 150 00:06:09,602 --> 00:06:10,103 DIRECTOR OF THE NATIONAL 151 00:06:10,169 --> 00:06:13,439 INSTITUTE ON AGING AND DR. GARY 152 00:06:13,506 --> 00:06:16,109 GIBBONS THE DIRECTOR OF THE 153 00:06:16,175 --> 00:06:17,710 NATIONAL HEART, LUNG AND BLOOD 154 00:06:17,777 --> 00:06:20,246 INSTITUTE AND WE'RE SUPPORT 155 00:06:20,313 --> 00:06:23,349 FANTASTIC STAFF, PROGRAM 156 00:06:23,416 --> 00:06:25,318 OFFICIALS, MEDICAL OFFICERS AND 157 00:06:25,384 --> 00:06:27,220 THEY MAKE THIS HAPPEN. 158 00:06:27,286 --> 00:06:29,155 I CAN'T TELL YOU HOW EXCITING IT 159 00:06:29,222 --> 00:06:31,491 IS TO SEE ALL OF YOU HERE AND 160 00:06:31,557 --> 00:06:32,625 PARTICULARLY THE FACT THAT SO 161 00:06:32,692 --> 00:06:34,427 MANY OF YOU HAVE NEVER BEEN TO 162 00:06:34,494 --> 00:06:35,862 THE NIH CAMPUS BEFORE. 163 00:06:35,928 --> 00:06:38,664 SO I FEEL LIKE IN A WAY WE'RE 164 00:06:38,731 --> 00:06:42,401 ACCOMPLISHING OUR GOAL JUST BY 165 00:06:42,468 --> 00:06:44,704 THE FACT THAT YOU ARE HERE WE'RE 166 00:06:44,771 --> 00:06:46,439 CREATING THIS COMMUNITY OF 167 00:06:46,506 --> 00:06:48,241 RESEARCHERS DEDICATED TO 168 00:06:48,307 --> 00:06:49,442 ADVANCING THE HEALTH OF PEOPLE 169 00:06:49,509 --> 00:06:51,377 WITH DOWN SYNDROME. 170 00:06:51,444 --> 00:07:00,186 IN MY BRIEF REMARKS -- I'M JUST 171 00:07:00,253 --> 00:07:05,057 GOING TO REMIND EVERYONE AND 172 00:07:05,124 --> 00:07:10,429 YOU'RE QUITE FAMILIAR WITH THE 173 00:07:10,496 --> 00:07:18,437 PROGRAM AND I'LL REMIND YOU THE 174 00:07:18,504 --> 00:07:21,507 PROGRAM STARTED WITH A 175 00:07:21,574 --> 00:07:30,383 PRESENTATION AND IMPRESSED THEM 176 00:07:30,449 --> 00:07:31,918 THEY GAVE THE MEMBERS OF 177 00:07:31,984 --> 00:07:35,321 CONGRESS GAVE HIM A STANDING 178 00:07:35,388 --> 00:07:37,723 OVATION AND THAT CAUSED AN 179 00:07:37,790 --> 00:07:39,192 INFLEXION IN FUNDING FOR DOWN 180 00:07:39,258 --> 00:07:40,860 SYNDROME RESEARCH. 181 00:07:40,927 --> 00:07:44,730 THAT WAS IN BELIEVE I 2017, 182 00:07:44,797 --> 00:07:48,568 WHICH THEN LED TO DISCUSSIONS IN 183 00:07:48,634 --> 00:07:51,103 THE SPRING OF 2018, I BELIEVE IT 184 00:07:51,170 --> 00:07:53,239 WAS, HOW ARE WE GOING SPEND THIS 185 00:07:53,306 --> 00:07:53,539 MONEY. 186 00:07:53,606 --> 00:07:58,945 AND THAT WAS THE GENESIS OF THE 187 00:07:59,011 --> 00:07:59,812 INCLUDE INITIATIVE. 188 00:07:59,879 --> 00:08:01,914 WHAT WE DISCUSSED AT THE TIME 189 00:08:01,981 --> 00:08:04,050 WAS TO CREATE THREE PROGRAM 190 00:08:04,116 --> 00:08:04,350 COMPONENTS. 191 00:08:04,417 --> 00:08:08,287 ONE WAS TO ADVANCE HIGH RISK, 192 00:08:08,354 --> 00:08:10,423 HIGH REWARD BASIC SCIENCE 193 00:08:10,489 --> 00:08:12,358 RESEARCH ON CHROMOSOME 21. 194 00:08:12,425 --> 00:08:14,894 ONE WAS THE NEED TO ASSEMBLE A 195 00:08:14,961 --> 00:08:17,396 LARGE STUDY POPULATION OF 196 00:08:17,463 --> 00:08:18,431 INDIVIDUALS WITH DOWN SYNDROME 197 00:08:18,497 --> 00:08:20,099 ACROSS THE LIFE SPAN. 198 00:08:20,166 --> 00:08:22,735 OF COURSE THERE HAD BEEN SMA 199 00:08:22,802 --> 00:08:25,371 SMALLIES BUT HAD NEVER BEEN -- 200 00:08:25,438 --> 00:08:29,609 SMALL STUDIED BUT NEVER COMBINED 201 00:08:29,675 --> 00:08:32,044 DO CREATE A BIG DATA SET AND 202 00:08:32,111 --> 00:08:33,779 DOWN SYNDROME WAS AN EXCLUSION 203 00:08:33,846 --> 00:08:35,882 FROM MANY CLINICAL TRIALS THAT 204 00:08:35,948 --> 00:08:36,616 INVOLVED MEDICATIONS PEOPLE WITH 205 00:08:36,682 --> 00:08:39,352 DOWN SYNDROME NEEDED SO THE 206 00:08:39,418 --> 00:08:44,690 THIRD AIM WAS PEOPLE TO INCLUDE 207 00:08:44,757 --> 00:08:47,426 INDIVIDUALS IN SKIFTH AND FUTURE 208 00:08:47,493 --> 00:08:48,694 CLINICAL TRIALS. 209 00:08:48,761 --> 00:08:52,665 SUPPORT FROM -- EXISTING AND 210 00:08:52,732 --> 00:08:53,532 CLINICAL TRIALS. 211 00:08:53,599 --> 00:08:54,934 THE SUPPORT CONTINUED TO 212 00:08:55,001 --> 00:08:56,502 INCREASE AND IT'S FLAT THIS YEAR 213 00:08:56,569 --> 00:09:01,073 BUT HAPPY IT WASN'T CUT. 214 00:09:01,140 --> 00:09:05,177 IN FISCAL YEAR '23 NIH INVESTED 215 00:09:05,244 --> 00:09:08,614 $90 MILLION IN DOWN SYNDROME AND 216 00:09:08,681 --> 00:09:11,317 MORE THAN 330 PROJECTS HAVE BEEN 217 00:09:11,384 --> 00:09:11,550 FUNDED. 218 00:09:11,617 --> 00:09:14,120 YOU CAN SEE THAT AT THE WEBSITE. 219 00:09:14,186 --> 00:09:18,925 WE SHOULD THANK CONGRESS FOR 220 00:09:18,991 --> 00:09:22,228 THEIR INCREDIBLE SUPPORT AND OF 221 00:09:22,295 --> 00:09:25,665 COURSE THAT'S PARTLY DUE TO THE 222 00:09:25,731 --> 00:09:26,465 INCREDIBLE ADVOCACY THAT HAS 223 00:09:26,532 --> 00:09:29,335 BEEN DEMONSTRATE A NUMBER OF 224 00:09:29,402 --> 00:09:31,070 GROUPS I'M JUST GOING GIVE BRIEF 225 00:09:31,137 --> 00:09:31,637 SNAPSHOTS. 226 00:09:31,704 --> 00:09:34,273 I OBVIOUSLY CANNOT ACKNOWLEDGE 227 00:09:34,340 --> 00:09:36,876 ALL THE WONDERFUL WORK BY THE 228 00:09:36,943 --> 00:09:37,576 PEOPLE IN THIS ROOM. 229 00:09:37,643 --> 00:09:39,312 I LOOK FORWARD TO THE 230 00:09:39,378 --> 00:09:42,415 PRESENTATIONS AND THE POSTERS. 231 00:09:42,481 --> 00:09:48,554 IF YOU HAVE FANTASTIC BREAKING 232 00:09:48,621 --> 00:09:51,257 NEWS YOU NEED IT TELL US ABOUT, 233 00:09:51,324 --> 00:09:52,992 WE EXPECT TESTIMONIES IN 234 00:09:53,059 --> 00:09:54,527 CONGRESS BY NIH WILL PROBABLY BE 235 00:09:54,593 --> 00:09:55,661 OCCURRING IN MAY. 236 00:09:55,728 --> 00:09:58,097 SO IF THERE'S ANECDOTES WE 237 00:09:58,164 --> 00:09:59,265 SHOULD KNOW ABOUT, PLEASE FEEL 238 00:09:59,332 --> 00:10:00,232 FREE TO SHARE THEM. 239 00:10:00,299 --> 00:10:01,200 WE SELECTED A FEW. 240 00:10:01,267 --> 00:10:04,770 IN AIM ONE, IT'S FOCUSSED ON 241 00:10:04,837 --> 00:10:05,504 BASIC TRANSLATIONAL AND 242 00:10:05,571 --> 00:10:06,772 DISCOVERY SCIENCE. 243 00:10:06,839 --> 00:10:09,475 IT'S FOCUSSED ON BIOMARKERS FOR 244 00:10:09,542 --> 00:10:14,180 EXAMPLE FOR ALZHEIMER'S DISEASE 245 00:10:14,246 --> 00:10:16,983 TO IDENTIFY RISK FACTOR AND TO 246 00:10:17,049 --> 00:10:20,419 CREATE CLINICAL TRIALS. 247 00:10:20,486 --> 00:10:25,691 PART OF THE BASIC SCIENCE WORK 248 00:10:25,758 --> 00:10:27,560 WAS FOR PRE CLINICAL MODELS 249 00:10:27,626 --> 00:10:32,698 INCLUDING ANIMAL MODELS AS WELL 250 00:10:32,765 --> 00:10:42,408 AS PLURIPOTENT STEM CELLS AND 251 00:10:42,475 --> 00:10:44,010 THEY'RE INVESTIGATING CONDITIONS 252 00:10:44,076 --> 00:10:45,311 ACROSS THE LIFE SPAN TO 253 00:10:45,378 --> 00:10:46,612 UNDERSTAND DOWN SYNDROME AND TO 254 00:10:46,679 --> 00:10:48,114 UNDERSTAND IN PARTICULAR WHY 255 00:10:48,180 --> 00:10:50,750 PEOPLE WITH DOWN SYNDROME ARE 256 00:10:50,816 --> 00:10:52,985 MORE PRONE TO CONDITIONS LIKE 257 00:10:53,052 --> 00:10:54,387 ALZHEIMER'S DISEASE BUT 258 00:10:54,453 --> 00:10:56,756 PROTECTED FROM OTHER CONDITIONS 259 00:10:56,822 --> 00:10:59,859 SUCH AS MYO CARDIAL INFARCTION. 260 00:10:59,925 --> 00:11:01,293 ONE HIGHLIGHT THAT WAS SELECTED 261 00:11:01,360 --> 00:11:09,368 IS THIS FROM THE GROUP OF YOUNG 262 00:11:09,435 --> 00:11:11,637 ET AL. CREATED MOLDS OF NEURAL 263 00:11:11,704 --> 00:11:13,039 HUMAN TISSUES THAT HAVE 264 00:11:13,105 --> 00:11:14,840 FUNCTIONAL CONNECTIVITY. 265 00:11:14,907 --> 00:11:17,309 WE NEED BETTER MODELS TO 266 00:11:17,376 --> 00:11:18,511 UNDERSTAND THE NEURAL PATHOLOGY 267 00:11:18,577 --> 00:11:20,479 IN DOWN SYNDROME. 268 00:11:20,546 --> 00:11:25,584 SO THEY DEVELOPED A 3-D BIO 269 00:11:25,651 --> 00:11:27,286 PRINTING PLATFORM THAT ARE ALONG 270 00:11:27,353 --> 00:11:29,255 WITH THE COMMERCIAL BIO PRINTER. 271 00:11:29,321 --> 00:11:31,991 THEY EXHIBIT FUNCTIONAL HUMAN 272 00:11:32,058 --> 00:11:34,427 NEURAL TISSUES WITH NEURAL 273 00:11:34,493 --> 00:11:35,694 CIRCUITS BETWEEN DEFINED NEURAL 274 00:11:35,761 --> 00:11:38,431 SUB TYPES AND FUNCTIONAL 275 00:11:38,497 --> 00:11:44,804 CONNECTIONS BETWEEN CORTICAL AND 276 00:11:44,870 --> 00:11:48,974 T 277 00:11:49,041 --> 00:11:50,409 TRIATAL TISSUE AND DESTRUCTION 278 00:11:50,476 --> 00:11:52,478 OF MYELIN. 279 00:11:52,545 --> 00:11:55,414 THE THINKING IS THAT THIS TYPE 280 00:11:55,481 --> 00:11:58,684 OF BIO PRINTING MODEL MAY BE 281 00:11:58,751 --> 00:12:03,255 EXTREMELY USEFUL IN DOWN SIN 282 00:12:03,322 --> 00:12:03,656 DRO 283 00:12:03,722 --> 00:12:04,390 DROME. 284 00:12:04,457 --> 00:12:08,094 THE MECHANISMS OF AUTO IMMUNITY 285 00:12:08,160 --> 00:12:08,727 HAVE BEEN DEMONSTRATED IN THE 286 00:12:08,794 --> 00:12:09,361 PAPER IN NATURE. 287 00:12:09,428 --> 00:12:11,197 WITH KNOW PEOPLE WITH DOWN 288 00:12:11,263 --> 00:12:16,068 SYNDROME ARE PRONE TO SEVERE IN 289 00:12:16,135 --> 00:12:17,636 TENSIONS AND AUTO IMMUNE 290 00:12:17,703 --> 00:12:20,306 CONDITIONS AND THEY INVESTIGATED 291 00:12:20,372 --> 00:12:24,143 MECHANISMS UNDERLYING AUTO 292 00:12:24,210 --> 00:12:26,412 IMMUNE SUSCEPTIBLE LOOKING AT 293 00:12:26,479 --> 00:12:28,581 THE HAND SCAPE AND SHOWED 294 00:12:28,647 --> 00:12:31,417 PERSISTENT ELEVATION OF UP TO 22 295 00:12:31,484 --> 00:12:33,385 CYTOKINES AT A STEADY STATE. 296 00:12:33,452 --> 00:12:37,089 THIS IS POINTING TOWARDS 297 00:12:37,156 --> 00:12:39,425 POSSIBLE THERAPEUTIC AVENUES 298 00:12:39,492 --> 00:12:42,895 USING BROAD IMMUNOSUPPRESS AND 299 00:12:42,962 --> 00:12:52,771 THEANT -- IMPRESSANTS LIKE JAK 300 00:12:52,838 --> 00:12:55,708 INHIBITERS AND WE LOOK AT 301 00:12:55,774 --> 00:12:58,277 INDIVIDUALS FROM BIRTH TO SENIOR 302 00:12:58,344 --> 00:12:58,577 AGES. 303 00:12:58,644 --> 00:13:01,714 AND IMPORTANT FOR THIS WORK IS 304 00:13:01,780 --> 00:13:02,781 THE ALZHEIMER'S BIOMARKER 305 00:13:02,848 --> 00:13:05,384 CONSORTIUM DOWN SYNDROME ALSO 306 00:13:05,451 --> 00:13:07,520 KNOWN AS ABCDS. 307 00:13:07,586 --> 00:13:11,924 SOME OF THE EXAMPLES OF WHAT 308 00:13:11,991 --> 00:13:14,827 THESE GROUPS ARE DOING NAR 309 00:13:14,894 --> 00:13:18,430 THEY'RE IT LOOKING AT PET 310 00:13:18,497 --> 00:13:20,065 SCANNING OF INDIVIDUALS WITH 311 00:13:20,132 --> 00:13:24,003 DOWN SYNDROME AND ESTIMATING 312 00:13:24,069 --> 00:13:26,172 EMERGENCE OF AMYLOID AND TAU 313 00:13:26,238 --> 00:13:29,008 BURDEN IN DOWN SIN DOME AND 314 00:13:29,074 --> 00:13:30,743 CO-ENROLLING IN THE DOWN 315 00:13:30,809 --> 00:13:33,245 SYNDROME OR TRCDS THAT WILL 316 00:13:33,312 --> 00:13:38,417 RECRUIT FOR CLINICAL TRIALS IN 317 00:13:38,484 --> 00:13:41,787 ALZHEIMER'S DISEASE. 318 00:13:41,854 --> 00:13:45,524 SOMETHING NEW THIS YEAR AIMS 319 00:13:45,591 --> 00:13:49,061 TOWARDS LARGE POPULATIONS OF 320 00:13:49,128 --> 00:13:51,063 PEOPLE WITH ALL AGES WITH DOWN 321 00:13:51,130 --> 00:13:51,330 SYNDROME. 322 00:13:51,397 --> 00:13:54,400 THEY REARE CEUTING PEOPLE WITH 323 00:13:54,466 --> 00:13:56,835 DOWN SYNDROME ACROSS THE LIFE 324 00:13:56,902 --> 00:13:59,872 SPAN COLLECTING BIO SPECIMENS 325 00:13:59,939 --> 00:14:03,576 AND DOING OMICS STUDIES FOR DEEP 326 00:14:03,642 --> 00:14:04,743 PHENOTYPING AND ALL THE DATA 327 00:14:04,810 --> 00:14:06,412 WILL BE PUBLICALLY AVAILABLE TO 328 00:14:06,478 --> 00:14:07,813 THE SCIENTIFIC COMMUNITY. 329 00:14:07,880 --> 00:14:09,815 AND THIS WILL CONSISTENT OF CHIN 330 00:14:09,882 --> 00:14:12,251 CAL SITES, COORDINATING CENTERS 331 00:14:12,318 --> 00:14:16,088 AND A SIMPLED BIO REPOSITORY. 332 00:14:16,155 --> 00:14:18,924 FOR AIM THREE, AGAIN BRIEF 333 00:14:18,991 --> 00:14:19,258 HIGHLIGHTS. 334 00:14:19,325 --> 00:14:22,394 THESE ARE THE CLINICAL TRIALS 335 00:14:22,461 --> 00:14:24,063 INCLUDING PEOPLE WITH DOWN 336 00:14:24,129 --> 00:14:24,330 SYNDROME. 337 00:14:24,396 --> 00:14:27,066 SO TREATMENT WITH JAK INHIBITORS 338 00:14:27,132 --> 00:14:32,271 CAN REDUCE INTERFERON-BASED 339 00:14:32,338 --> 00:14:33,005 INFLAMMATION. 340 00:14:33,072 --> 00:14:35,274 THESE ARE SHOWING POTENTIAL 341 00:14:35,341 --> 00:14:36,275 BENEFITS FOR AUTO IMMUNE AND 342 00:14:36,342 --> 00:14:40,546 OTHER DISORDERS COMMON TO PEOPLE 343 00:14:40,613 --> 00:14:42,448 WITH DOWN SYNDROME WE MAY HEAR 344 00:14:42,514 --> 00:14:46,652 ABOUT LATER IN THE DAY. 345 00:14:46,719 --> 00:14:50,389 AND THE COMBINATION OF ATO 346 00:14:50,456 --> 00:14:52,057 OXYHAS BEEN IDENTIFIED AS A 347 00:14:52,124 --> 00:14:56,328 PROMISING TREATMENT FOR 348 00:14:56,395 --> 00:14:58,864 OBSTRUCTIVE SLEEP APNEA IN 349 00:14:58,931 --> 00:15:01,700 CHILDREN WITH DOWN SYNDROME AND 350 00:15:01,767 --> 00:15:06,405 SPEAKING OF SLEEP APNEA, THE 351 00:15:06,472 --> 00:15:09,975 FEASIBILITY AND PERFORMANCE OF 352 00:15:10,042 --> 00:15:11,143 TESTING AT HOME IS A MAJOR 353 00:15:11,210 --> 00:15:14,113 SUCCESS OF THE INCLUDE 354 00:15:14,179 --> 00:15:14,413 INITIATIVE. 355 00:15:14,480 --> 00:15:16,348 SO NOBODY WANTS TO GO INTO A 356 00:15:16,415 --> 00:15:18,217 HOSPITAL OR CLINIC AND BE TESTED 357 00:15:18,284 --> 00:15:19,518 FOR SLEEP APNEA. 358 00:15:19,585 --> 00:15:20,352 YOU NEVER SLEEP WELL. 359 00:15:20,419 --> 00:15:22,621 I KNOW THAT FOR A FACT. 360 00:15:22,688 --> 00:15:26,892 MY HUSBAND HAS HAD SLEEP STUDIES 361 00:15:26,959 --> 00:15:28,761 AND COMPLAINED NON STOP ABOUT 362 00:15:28,827 --> 00:15:29,028 THEM. 363 00:15:29,094 --> 00:15:31,597 NOT ONLY THAT, AS THE A DEARTH 364 00:15:31,664 --> 00:15:36,001 OF SLEEP LABORATORIES CAPABLE OF 365 00:15:36,068 --> 00:15:38,837 DOING THIS TESTING PARTICULARLY 366 00:15:38,904 --> 00:15:41,407 IN YOUTH WIN NEUROCOGNITIVE 367 00:15:41,473 --> 00:15:41,740 DISABILITIES. 368 00:15:41,807 --> 00:15:43,375 IN THIS STUDY IN THE JOURNAL OF 369 00:15:43,442 --> 00:15:45,844 CLINICAL SLEEP MEDICINE THE ERS 370 00:15:45,911 --> 00:15:48,947 TEST THE FEASIBILITY, 371 00:15:49,014 --> 00:15:53,185 ACCESSIBILITY OF IN HOME LEVEL 2 372 00:15:53,252 --> 00:16:02,161 SLEEP APNEA TESTING VERSUS POLY 373 00:16:02,227 --> 00:16:03,562 SOMNOGRAPHY AND TESTS FEMALES 374 00:16:03,629 --> 00:16:05,197 AND FEMALES AND 41 OF THEM 375 00:16:05,264 --> 00:16:08,867 COMPLETED THE HOME TESTING AND 376 00:16:08,934 --> 00:16:10,969 41 COMPLETED THE OTHER. 377 00:16:11,036 --> 00:16:12,538 40 OF THE PEOPLE UNDER WENT BOTH 378 00:16:12,604 --> 00:16:14,406 TESTS AND THE HOME SLEEP STUDY 379 00:16:14,473 --> 00:16:20,279 WAS DETERMINED TO BE WELL 380 00:16:20,346 --> 00:16:21,513 TOLERATED, RELIABLE AND 381 00:16:21,580 --> 00:16:21,814 PREFERABLE. 382 00:16:21,880 --> 00:16:23,949 WANT TO SLEEP IN YOUR OWN BED IF 383 00:16:24,016 --> 00:16:26,919 YOU CAN TO HOSPITAL SLEEP 384 00:16:26,985 --> 00:16:30,189 STUDIES TO IDENTIFIED SLEEP 385 00:16:30,255 --> 00:16:30,389 APNEA. 386 00:16:30,456 --> 00:16:31,657 THIS IS A MAJOR ADVANCE 387 00:16:31,724 --> 00:16:32,925 PARTICULARLY FOR YOUTH SUSPECTED 388 00:16:32,991 --> 00:16:34,326 TO HAVE SLEEP APNEA. 389 00:16:34,393 --> 00:16:36,028 I FORGOT TO MENTION OWN THE 390 00:16:36,095 --> 00:16:38,430 FIRST SLIDE WHEN I SHOWED THE 391 00:16:38,497 --> 00:16:40,866 VEN DIAGRAM THERE'S TWO OTHER 392 00:16:40,933 --> 00:16:41,567 COMPONENTS OF THE INCLUDE 393 00:16:41,633 --> 00:16:41,967 INITIATIVE. 394 00:16:42,034 --> 00:16:43,469 ONE IS THE CREATION OF NEW 395 00:16:43,535 --> 00:16:44,103 RESOURCES THAT CAN BE USED BY 396 00:16:44,169 --> 00:16:46,004 ALL. 397 00:16:46,071 --> 00:16:49,408 AND THE OTHER IS TO INCREASE THE 398 00:16:49,475 --> 00:16:50,376 WORKFORCE. 399 00:16:50,442 --> 00:16:51,710 WE'LL BE HEARING IF THE INCLUDE 400 00:16:51,777 --> 00:16:54,279 DATA HUB WHICH HAS BEEN A 401 00:16:54,346 --> 00:16:56,215 TERRIFIC RESOURCE. 402 00:16:56,281 --> 00:16:58,417 IT'S CLOUD-BASED. 403 00:16:58,484 --> 00:17:00,753 IT'S BEEN DEVELOPED THROUGH THE 404 00:17:00,819 --> 00:17:01,820 COORDINATING CENTER AND PROVIDES 405 00:17:01,887 --> 00:17:04,890 FREE ACCESS TO LARGE SCALE DATA 406 00:17:04,957 --> 00:17:05,324 RESOURCES. 407 00:17:05,391 --> 00:17:08,494 YOU CAN PULLED CUSTOM COHORT 408 00:17:08,560 --> 00:17:10,462 DATA SETS BASED ON YOUR 409 00:17:10,529 --> 00:17:12,598 PARTICULAR INTEREST AND 410 00:17:12,664 --> 00:17:14,900 PARTICIPANTS, BIO SPECIMENS AND 411 00:17:14,967 --> 00:17:18,103 CLINICAL AND OMIC DATA AND 412 00:17:18,170 --> 00:17:18,670 ENCOURAGING COLLABORATIONS 413 00:17:18,737 --> 00:17:19,238 AMONGST THE INVESTIGATORS. 414 00:17:19,304 --> 00:17:21,106 HERE'S THE WEBSITE. 415 00:17:21,173 --> 00:17:23,976 AND COMING SOON, WE HAVE THE 416 00:17:24,042 --> 00:17:26,545 EXPERIMENTAL MODELS OF DOWN 417 00:17:26,612 --> 00:17:28,347 SYNDROME RESEARCHER PORTAL. 418 00:17:28,414 --> 00:17:29,481 THIS IS A NEW RESOURCE. 419 00:17:29,548 --> 00:17:31,650 IT'S DESIGN TO FACILITATE 420 00:17:31,717 --> 00:17:33,218 SHARING AND ANALYSIS OF DATA 421 00:17:33,285 --> 00:17:35,320 SETS GENERATE FROM EXPERIMENTAL 422 00:17:35,387 --> 00:17:37,356 MODELS OF DOWN SYNDROME 423 00:17:37,423 --> 00:17:39,892 INCLUDING ANIMAL MODELS AND 424 00:17:39,958 --> 00:17:40,592 IPSCs. 425 00:17:40,659 --> 00:17:42,861 THERE'LL BE NEW KEY FEATURES. 426 00:17:42,928 --> 00:17:44,296 A STUDY FINDER. 427 00:17:44,363 --> 00:17:46,165 THERE WILL BE AN INDEX OF 428 00:17:46,231 --> 00:17:48,434 PUBLICATIONS FOR WHAT IS 429 00:17:48,500 --> 00:17:50,836 INCLUDED IN THE PORTAL. 430 00:17:50,903 --> 00:17:53,005 THERE'S AN EX PLORATION PORTAL 431 00:17:53,071 --> 00:17:58,944 FOR ANIMAL MODELS AND FOR GENES, 432 00:17:59,011 --> 00:18:01,046 PROTAENZ -- 433 00:18:04,049 --> 00:18:06,318 PROTEINS AND METABOLITES. 434 00:18:06,385 --> 00:18:08,320 AND WE'RE INTERESTED IN THE 435 00:18:08,387 --> 00:18:10,022 ANIMAL MODEL AND IT WILL GIVE 436 00:18:10,088 --> 00:18:11,490 THE ABILITY TO LOOK AT WHICH 437 00:18:11,557 --> 00:18:22,100 GENES ARE TRIPLICATED AND THEN A 438 00:18:28,240 --> 00:18:30,409 LINK TO THE ORIGINAL 439 00:18:30,476 --> 00:18:31,376 PUBLICATIONS. 440 00:18:31,443 --> 00:18:34,413 THEN ANOTHER NEW TOOL WILL BE 441 00:18:34,480 --> 00:18:38,417 THE EXPERIMENTAL MODELS DATA SET 442 00:18:38,484 --> 00:18:39,785 EXPLORATION TOOL TO INTERACT 443 00:18:39,852 --> 00:18:41,186 WITH DATA SETS FROM EXPERIMENTAL 444 00:18:41,253 --> 00:18:45,991 MODELS BY EXPLORING GENES, 445 00:18:46,058 --> 00:18:47,693 PROTEINS AND METABOLITES, 446 00:18:47,759 --> 00:18:48,994 TISSUES, ORGANS AND CELL TYPES 447 00:18:49,061 --> 00:18:49,962 AS I SAID EARLIER. 448 00:18:50,028 --> 00:18:54,399 AND YOU'LL BE ABLE TO USE THIS 449 00:18:54,466 --> 00:18:57,836 IN PORTAL ANALYSIS DASHBOARD TO 450 00:18:57,903 --> 00:19:03,342 RAPIDLY VISUAL THE EFFECTS OF 451 00:19:03,408 --> 00:19:04,776 TRYSOMY 21 AND ALLOWED CREATION 452 00:19:04,843 --> 00:19:05,277 OF THE SHARED RESOURCES. 453 00:19:06,545 --> 00:19:08,514 DEF 454 00:19:19,258 --> 00:19:24,796 WE HAVE AN INFUSION OF YOUNGER 455 00:19:24,863 --> 00:19:26,932 PEOPLE WHO SEE WORK UNDOWN 456 00:19:26,999 --> 00:19:28,400 SYNDROME AS AN IMPORTANT AREA TO 457 00:19:28,467 --> 00:19:30,369 FOCUS THEIR CAREER AND THE 458 00:19:30,435 --> 00:19:33,906 INCLUDE INITIATIVE FUND THE DS3 459 00:19:33,972 --> 00:19:35,040 THE DATA SCIENCE DIVERSE 460 00:19:35,107 --> 00:19:37,342 SCHOLARS IN DOWN SYNDROME 461 00:19:37,409 --> 00:19:41,647 RESEARCH. 462 00:19:41,713 --> 00:19:42,614 INCLUDE DATA COORDINATION COURSE 463 00:19:42,681 --> 00:19:45,484 IN DATA SCIENCE AND YOU CAN SEE 464 00:19:45,551 --> 00:19:46,418 THAT 2023 SCHOLARS HERE IN 465 00:19:46,485 --> 00:19:50,255 COLORADO. 466 00:19:50,322 --> 00:19:52,391 AND THEY LEARN ABOUT THE BASICS 467 00:19:52,457 --> 00:19:54,993 OF GENERATION IDENTIFICATION AND 468 00:19:55,060 --> 00:19:57,396 COLLECTION OF HIGH CONTENT 469 00:19:57,462 --> 00:19:58,363 MULTI-DIMENSIONAL DATA SETS AND 470 00:19:58,430 --> 00:20:02,200 LEARN HOW TO WORK WITH THOSE 471 00:20:02,267 --> 00:20:03,802 DATA SETS INCLUDE PAY FOR THEIR 472 00:20:03,869 --> 00:20:07,339 TRAVEL, THEIR LODGING, AND GIVE 473 00:20:07,406 --> 00:20:15,881 THEM A PER DIEM AND 11 TRAINEES 474 00:20:15,948 --> 00:20:16,982 WERE SUPPORTED AND THERE'LL BE 475 00:20:17,049 --> 00:20:18,450 ANOTHER COURSE IN 2025. 476 00:20:18,517 --> 00:20:21,253 THERE'S THE QR CODE THERE. 477 00:20:21,320 --> 00:20:22,888 THIS HAS BEEN TERRIFIC IN TERMS 478 00:20:22,955 --> 00:20:25,123 AGAIN OF BRINGING TEAM INTO THE 479 00:20:25,190 --> 00:20:27,025 FIELD, GIVING THEM THE TOOLS 480 00:20:27,092 --> 00:20:32,497 THEY NEED TO SUCCEED. 481 00:20:32,564 --> 00:20:36,668 AND THERE'S AN ENORMOUS AMOUNT 482 00:20:36,735 --> 00:20:40,038 OF THAT CAN BE DONE IN THE DATA 483 00:20:40,105 --> 00:20:41,039 HUB, FOR EXAMPLE. 484 00:20:41,106 --> 00:20:44,142 NO IRB PROTOCOLS ARE NEEDED. 485 00:20:44,209 --> 00:20:46,178 YOU DON'T NEED TO GET QUALIFIED 486 00:20:46,244 --> 00:20:47,713 TO WORK WITH ANIMAL MODELS. 487 00:20:47,779 --> 00:20:50,282 YOU CAN START ASKING QUESTIONS 488 00:20:50,349 --> 00:20:50,882 AND TESTING HYPOTHESES RIGHT 489 00:20:50,949 --> 00:20:53,986 NOW. 490 00:20:54,052 --> 00:20:56,822 SO JUST BRIEFLY AS MELISSA SAID, 491 00:20:56,888 --> 00:20:59,424 MY LABORATORY IS ONE OF THE FEW 492 00:20:59,491 --> 00:21:01,960 ON CAMPUS SO WHAT YOU DON'T 493 00:21:02,027 --> 00:21:05,664 REALIZE IS THIS IS LIKE AN 494 00:21:05,731 --> 00:21:06,698 ENORMOUS COLLEGE CAMPUS AND IN 495 00:21:06,765 --> 00:21:17,275 MANY BUILDINGS ARE WET LAB -- 496 00:21:20,846 --> 00:21:24,182 LABORATORIES AND THE HOSPITAL 497 00:21:24,249 --> 00:21:26,284 WHICH IS AT THE CENTER OF THE 498 00:21:26,351 --> 00:21:27,586 CAMPUS, ARE ALL DOING RESEARCH. 499 00:21:27,653 --> 00:21:30,022 IN MY LABORATORY AT THE OPPOSITE 500 00:21:30,088 --> 00:21:31,890 END OF THE CAMPUS WE'RE ONE OF 501 00:21:31,957 --> 00:21:33,425 THE FEW LABORATORIES FOCUSSING 502 00:21:33,492 --> 00:21:36,395 ON DOWN SYNDROME AND WE ARE 503 00:21:36,461 --> 00:21:38,697 TAKING THE OPPORTUNITY OF THE 504 00:21:38,764 --> 00:21:42,100 FACT THAT MANY PREGNANT PEOPLE 505 00:21:42,167 --> 00:21:43,635 ARE TESTED FOR DOWN SYNDROME. 506 00:21:43,702 --> 00:21:46,104 WE BELIEVE THIS IS AN 507 00:21:46,171 --> 00:21:48,774 OPPORTUNITY TO ADVANCE THE 508 00:21:48,840 --> 00:21:54,179 HEALTH OF THE FETUS AND PERHAPS 509 00:21:54,246 --> 00:21:54,880 IMPROVED INDEPENDENT LIFE 510 00:21:54,946 --> 00:21:55,313 SKILLS. 511 00:21:55,380 --> 00:21:57,616 SO WE'RE TESTING USING ANIMAL 512 00:21:57,683 --> 00:22:00,419 MODELS AND IPSCs. 513 00:22:00,485 --> 00:22:01,586 THE VARIOUS COMPOUNDS THAT MIGHT 514 00:22:01,653 --> 00:22:07,959 DO THIS SO WE HAVE AN IN VITRO 515 00:22:08,026 --> 00:22:09,528 APOACH AS WELL AS AN IN VIVO 516 00:22:09,594 --> 00:22:13,665 APPROACH AND TO GIVE A SENSE OF 517 00:22:13,732 --> 00:22:15,367 MY PERSONAL COMMITMENT AND MY 518 00:22:15,434 --> 00:22:16,668 LABORATORY IS EXCITED ABOUT 519 00:22:16,735 --> 00:22:18,770 USING SOME OF THE RESOURCES 520 00:22:18,837 --> 00:22:19,337 AVAILABLE THROUGH INCLUDE. 521 00:22:19,404 --> 00:22:23,508 WE HAVE BEEN WORKING WITH FOUR 522 00:22:23,575 --> 00:22:25,310 DIFFERENT MOUSE MODELS OF DOWN 523 00:22:25,377 --> 00:22:25,911 SYNDROME AND THEY'RE CLEARLY 524 00:22:25,977 --> 00:22:29,047 DIFFERENT FROM EACH OTHER WE 525 00:22:29,114 --> 00:22:31,416 KNOW PHENOTYPICALLY HOW 526 00:22:31,483 --> 00:22:32,718 DIFFERENT THEY ARE BUT MORE WE 527 00:22:32,784 --> 00:22:35,253 CAN DO IN TERMS OF GENOMIC AND 528 00:22:35,320 --> 00:22:36,121 TRANSCRIPTOMIC ANALYSES IN TERMS 529 00:22:36,188 --> 00:22:45,931 OF COMPARING THEM. 530 00:22:45,997 --> 00:22:49,201 MY LABORATORY IS NOT FUNDED 531 00:22:49,267 --> 00:22:50,902 THROUGH INCLUDE. 532 00:22:50,969 --> 00:22:54,172 IT'S PURELY EXTRAMURAL. 533 00:22:54,239 --> 00:22:55,874 BECAUSE THE RESOURCES ARE 534 00:22:55,941 --> 00:22:57,442 PUBLICALLY AVAILABLE, WE CAN USE 535 00:22:57,509 --> 00:22:59,010 RESOURCES AS CAN ALL OF YOU. 536 00:22:59,077 --> 00:23:02,147 SO IT'S AN INCREDIBLY EXCITING 537 00:23:02,214 --> 00:23:03,115 TIME. 538 00:23:03,181 --> 00:23:06,418 I WISH YOU ALL WELL WITH YOUR 539 00:23:06,485 --> 00:23:09,554 RESEARCH AND WE LOOK FORWARD TO 540 00:23:09,621 --> 00:23:10,689 PRESENTATIONS AND DISCUSSIONS. 541 00:23:10,756 --> 00:23:13,825 I JUST WANT TO MENTION I 542 00:23:13,892 --> 00:23:16,061 PROVIDED BRIEF SNAPSHOTS OF EACH 543 00:23:16,128 --> 00:23:18,063 OF THE AIMS LOOKING FORWARD TO 544 00:23:18,130 --> 00:23:20,065 HEAR MORE ABOUT YOUR SUCCESSES 545 00:23:20,132 --> 00:23:21,933 AND CHALLENGES AND THEN ON THE 546 00:23:22,000 --> 00:23:23,902 RIGHT HERE PLEASE KEEP IN MIND 547 00:23:23,969 --> 00:23:26,404 THAT THE INCLUDE INITIATIVE HAS 548 00:23:26,471 --> 00:23:28,006 CREATED NEW RESOURCES AND WE ARE 549 00:23:28,073 --> 00:23:30,575 ALSO VERY FOCUSSED ON INCREASING 550 00:23:30,642 --> 00:23:33,545 THE WORKFORCE OF PEOPLE WHO ARE 551 00:23:33,612 --> 00:23:35,413 DEDICATED TO DOING RESEARCH IN 552 00:23:35,480 --> 00:23:36,848 DOWN SYNDROME TO ADVANCE THE 553 00:23:36,915 --> 00:23:38,016 HEALTH OF PEOPLE WITH DOWN 554 00:23:38,083 --> 00:23:38,416 SYNDROME. 555 00:23:38,483 --> 00:23:48,827 THANK YOU VERY MUCH. 556 00:23:54,733 --> 00:23:57,335 >> THANK YOU VERY MUCH FOR YOUR 557 00:23:57,402 --> 00:24:00,305 WELCOMING REMARKS AND INSIGHTFUL 558 00:24:00,372 --> 00:24:01,740 COMMENTS ABOUT SOME OF THE DOWN 559 00:24:01,807 --> 00:24:02,908 SYNDROME RESEARCH BEING 560 00:24:02,974 --> 00:24:04,276 SUPPORTED THROUGH THE INCLUDE 561 00:24:04,342 --> 00:24:05,544 PROJECT, DR. BIANCHI. 562 00:24:05,610 --> 00:24:09,948 NOW IT'S MY PLEASURE TO 563 00:24:10,015 --> 00:24:18,223 INTRODUCE MR. ISAIAH LOMBARDO 564 00:24:18,290 --> 00:24:22,060 HE WORKS FULL TIME AT SHAKE SHAM 565 00:24:22,127 --> 00:24:23,228 SHACK AND PARTICIPATED OVER THE 566 00:24:23,295 --> 00:24:25,630 YEARS IN HORSEBACK RIDING, 567 00:24:25,697 --> 00:24:28,433 BOXING, BASEBALL, BOWLING AND 568 00:24:28,500 --> 00:24:32,170 BOSTON BALLET DANCE CLASS. 569 00:24:32,237 --> 00:24:35,006 I'M EXHAUSTED THINKING ABOUT 570 00:24:35,073 --> 00:24:35,273 THAT. 571 00:24:35,340 --> 00:24:40,545 HE DANCES IN A CLASS WITH ADULTS 572 00:24:40,612 --> 00:24:44,516 AND HAS A FACEBOOK PAGE CALLED 573 00:24:44,583 --> 00:24:45,650 ISAIAH'S ADVENTURES AND LOVE 574 00:24:45,717 --> 00:24:46,918 SPENDING TIME WITH HIS FRIENDS 575 00:24:46,985 --> 00:24:47,352 AND FAMILY. 576 00:24:47,419 --> 00:24:50,288 SO PLEASE JOIN ME IN WELCOMING 577 00:24:50,355 --> 00:24:54,392 MR. ISAIAH LOMBARDO TO GIVE 578 00:24:54,459 --> 00:24:54,826 PERSPECTIVES FROM A 579 00:24:54,893 --> 00:25:03,602 SELF-ADVOCATE. 580 00:25:03,668 --> 00:25:05,437 >> HI. 581 00:25:05,503 --> 00:25:08,106 I WANT TO SAY THANK YOU FOR 582 00:25:08,173 --> 00:25:10,542 INVITING ME HERE TO SPEAK TO 583 00:25:10,609 --> 00:25:10,709 YOU. 584 00:25:10,775 --> 00:25:12,277 I'M VERY EXCITED FOR THE 585 00:25:12,344 --> 00:25:12,811 OPPORTUNITY. 586 00:25:12,878 --> 00:25:15,513 I WANTED TO TELL A STORY TO GIVE 587 00:25:15,580 --> 00:25:20,352 AN EXAMPLE OF HOW I'M HERE 588 00:25:20,418 --> 00:25:20,752 TODAY. 589 00:25:20,819 --> 00:25:26,892 BECAUSE OF RESEARCH I WAS DOWN 590 00:25:26,958 --> 00:25:31,196 TWO MONTHS PREMATURE WEIGHING 591 00:25:31,263 --> 00:25:35,734 ONLY TWO POUNDS AND I WAS BORN 592 00:25:35,800 --> 00:25:40,305 WITH A DISEASE AND IT CAUSED MY 593 00:25:40,372 --> 00:25:46,378 INTESTINES NOT TO POOP OUT OF ME 594 00:25:46,444 --> 00:25:51,950 I WAS SICK AND THEY DAY BIOPSY 595 00:25:52,017 --> 00:25:56,922 AND HAD AMAZING RESOURCES TO PUT 596 00:25:56,988 --> 00:26:07,499 A KOL OF THE MY BAG ON ME -- 597 00:26:10,168 --> 00:26:11,569 COLOSTOMY BAG ON ME AND SOME 598 00:26:11,636 --> 00:26:14,472 WITH THIS DISEASE PASSED AWAY 599 00:26:14,539 --> 00:26:18,543 FROM THE DISEASE. 600 00:26:18,610 --> 00:26:19,945 DUE TO RESEARCH SOME FIGURED OUT 601 00:26:20,011 --> 00:26:22,080 WHAT CAUSED IT AND HOW TO TREAT 602 00:26:22,147 --> 00:26:25,784 IT AND HOW TO HAVE BABIES LIKE 603 00:26:25,850 --> 00:26:28,219 ME LIVE AND GROW WHILE HAVING 604 00:26:28,286 --> 00:26:30,422 THIS DISEASE. 605 00:26:30,488 --> 00:26:35,460 MY EXPERIENCE IS ONE EXAMPLE 606 00:26:35,527 --> 00:26:40,632 THAT IMPROVED MY CARE AND PEOPLE 607 00:26:40,699 --> 00:26:46,504 WITH DOWN SYNDROME AND NOW 608 00:26:46,571 --> 00:26:49,140 BABIES BORN AFTER ME WILL HAVE 609 00:26:49,207 --> 00:26:51,009 EVEN BETTER LIVES DUE TO WHAT 610 00:26:51,076 --> 00:26:52,978 YOU HAVE BEEN WORKING ON TODAY. 611 00:26:53,044 --> 00:26:56,815 THAT IS PRETTY COOL. 612 00:26:56,881 --> 00:27:00,518 RESEARCH IS THE REASON THAT 613 00:27:00,585 --> 00:27:03,888 INDIVIDUALS WITH DOWN SYNDROME 614 00:27:03,955 --> 00:27:05,890 HAVE BETTER LIFE STYLES AND 615 00:27:05,957 --> 00:27:07,892 BETTER LEARNING OPPORTUNITIES. 616 00:27:07,959 --> 00:27:18,470 THERE'S A LOT OF RESEARCH AND 617 00:27:23,708 --> 00:27:29,814 THERE'S INDIVIDUALS WITH DOWN 618 00:27:29,881 --> 00:27:30,081 SYNDROME. 619 00:27:30,148 --> 00:27:32,083 MY MOTHER TAUGHT ME TO USE MY 620 00:27:32,150 --> 00:27:39,591 VOICE FROM A YOUNG AGE. 621 00:27:39,657 --> 00:27:45,430 I LEARNED TO SPEAK UP FOR MYSELF 622 00:27:45,497 --> 00:27:50,702 AND SHE SPOKE TO SCHOOLS AND 623 00:27:50,769 --> 00:27:51,403 COLLEGE STUDENTS ABOUT RAISING 624 00:27:51,469 --> 00:27:52,971 ME AND THEN I TOOK OVER AND NOW 625 00:27:53,038 --> 00:27:58,443 I TALK TO THEM ABOUT MY LIFE 626 00:27:58,510 --> 00:27:59,377 LIVING WITH DOWN SYNDROME AND 627 00:27:59,444 --> 00:28:01,112 TALK TO SCHOOLS AND GENETIC 628 00:28:01,179 --> 00:28:01,780 COUNSELING PROGRAMS AND COLLEGES 629 00:28:01,846 --> 00:28:05,216 ABOUT MY LIFE. 630 00:28:05,283 --> 00:28:08,887 BEFORE COVID I USED TO SPEAK TO 631 00:28:08,953 --> 00:28:10,622 EVERY FOURTH GRADE CLASS TO TALK 632 00:28:10,688 --> 00:28:15,060 TO KIDS ABOUT FRIENDSHIPS AND 633 00:28:15,126 --> 00:28:17,562 DIFFERENCES IN HOW WE'RE MORE 634 00:28:17,629 --> 00:28:18,430 THE SAME THAN DIFFERENT. 635 00:28:18,496 --> 00:28:22,434 I LOVE SHARING MY STORY ABOUT 636 00:28:22,500 --> 00:28:23,668 WHAT MY LIFE IS LIKE. 637 00:28:23,735 --> 00:28:26,404 I LEARNED YOUNG THAT MY VOICE IS 638 00:28:26,471 --> 00:28:31,242 IMPORTANT. 639 00:28:31,309 --> 00:28:34,412 WHEN IT COMES TO MY INVOLVEMENT 640 00:28:34,479 --> 00:28:41,186 IN RESEARCH IT'S ASSUMED. 641 00:28:41,252 --> 00:28:41,953 IT'S IMPORTANT TO HAVE 642 00:28:42,020 --> 00:28:47,325 CONFIDENCE AND TREAT PEOPLE AS 643 00:28:47,392 --> 00:28:49,260 INDIVIDUALS. 644 00:28:49,327 --> 00:28:59,070 AND I'M CURRENTLY DOING A 645 00:28:59,137 --> 00:29:05,944 CLINICAL TRIAL IN COLORADO WITH 646 00:29:06,010 --> 00:29:10,748 THE AMAZING DR. ESPINOZA AND I 647 00:29:10,815 --> 00:29:11,182 WAS NERVOUS. 648 00:29:11,249 --> 00:29:14,586 MY MOTHER WANTED ME TO DO IT AND 649 00:29:14,652 --> 00:29:17,155 WAS NOT NERVOUS AT ALL AND I HAD 650 00:29:17,222 --> 00:29:19,557 LOTS OF QUESTIONS AND HE TOOK 651 00:29:19,624 --> 00:29:21,059 THE TIME TO ANSWER EVERY 652 00:29:21,126 --> 00:29:23,561 QUESTION I HAD WHEN I SIGNED UP. 653 00:29:23,628 --> 00:29:26,397 DURING THE SCREENING FOR THE 654 00:29:26,464 --> 00:29:27,699 TRIAL THE RESOURCE TEAM ALSO 655 00:29:27,765 --> 00:29:29,534 ADDRESSED ME AND TOLD ME EXACTLY 656 00:29:29,601 --> 00:29:31,369 WHAT WAS HAPPENING. 657 00:29:31,436 --> 00:29:36,474 YOU CAN SEE PICTURES OF ME IN 658 00:29:36,541 --> 00:29:36,808 THE PROCESS. 659 00:29:36,875 --> 00:29:40,211 AND THEY TALK TO ME AT EVERY 660 00:29:40,278 --> 00:29:41,880 VISIT AND MAKE SURE I UNDERSTAND 661 00:29:41,946 --> 00:29:45,083 WHAT IS HAPPENING AND ANSWERS 662 00:29:45,150 --> 00:29:54,392 ALL MY QUESTIONS. 663 00:29:54,459 --> 00:29:59,097 AND I'M AN ADULT NOW AND THE 664 00:29:59,164 --> 00:30:00,532 WANT PEOPLE TO TALK TO ME AND 665 00:30:00,598 --> 00:30:04,636 GOT MY QUESTIONS ANSWERS AND 666 00:30:04,702 --> 00:30:05,970 IT'S A GREAT EXPERIENCE AND I 667 00:30:06,037 --> 00:30:09,807 JOINED THE STUDY AND I COULD 668 00:30:09,874 --> 00:30:13,344 HELP DR. ESPINOZA'S TEAM LEARN 669 00:30:13,411 --> 00:30:16,047 MORE ABOUT THE MEDICATION AND 670 00:30:16,114 --> 00:30:19,584 HOW IT WORKS. 671 00:30:19,651 --> 00:30:23,288 I GET TO BE PART OF IT AND MY 672 00:30:23,354 --> 00:30:31,529 SKIN IS GETTING BABY SOFT AGAIN. 673 00:30:31,596 --> 00:30:33,364 IT'S ALSO IMPORTANT THE 674 00:30:33,431 --> 00:30:34,365 QUESTIONS OF AREAS OF FOCUS COME 675 00:30:34,432 --> 00:30:37,235 FROM THOSE WHO LIVE WITH DOWN 676 00:30:37,302 --> 00:30:37,502 SYNDROME. 677 00:30:37,569 --> 00:30:41,039 I HOPE WE TALK TO INDIVIDUALS 678 00:30:41,105 --> 00:30:45,176 WITH DOWN SYNDROME TO HEAR THEIR 679 00:30:45,243 --> 00:30:45,443 OPINIONS. 680 00:30:45,510 --> 00:30:47,212 PEOPLE WITH THIS NEED TO BE PART 681 00:30:47,278 --> 00:30:50,415 OF DEVELOPING RESOURCE QUESTIONS 682 00:30:50,481 --> 00:30:53,551 I HOPE THE STUDY IN QUESTIONS 683 00:30:53,618 --> 00:30:56,387 ARE GUIDED BY OUR FAMILIES AND 684 00:30:56,454 --> 00:30:58,523 BY US. 685 00:30:58,590 --> 00:31:00,258 WE HAVE LIVED EXPERIENCES ASKING 686 00:31:00,325 --> 00:31:02,660 US WHAT WE WANT AND WHAT WE HOPE 687 00:31:02,727 --> 00:31:04,829 FOR AND THERE ARE AREAS TO 688 00:31:04,896 --> 00:31:06,397 IMPROVE IN. 689 00:31:06,464 --> 00:31:09,100 I HOPE RESEARCH CONTINUES IN 690 00:31:09,167 --> 00:31:13,905 AREAS SO HELP OUR LIVES IMPROVE. 691 00:31:13,972 --> 00:31:15,106 MORE RESEARCH TO TEACH PEOPLE 692 00:31:15,173 --> 00:31:16,674 HOW WE LEARN AND DEVELOP AND 693 00:31:16,741 --> 00:31:20,912 MORE RESEARCH TO HELP CHILDREN 694 00:31:20,979 --> 00:31:23,581 WHO HAVE BEHAVIORAL OR ANY 695 00:31:23,648 --> 00:31:26,851 MEDICAL CONDITIONS. 696 00:31:26,918 --> 00:31:33,691 MORE RESEARCH ON EMOTIONS AND 697 00:31:33,758 --> 00:31:36,694 HOW IT HELP PEOPLE WITH DOWN 698 00:31:36,761 --> 00:31:39,998 SYNDROME COPE AND HANDLE 699 00:31:40,064 --> 00:31:40,932 DIFFICULT TIMES AND MORE 700 00:31:40,999 --> 00:31:45,770 RESEARCH ON MEDICATIONS OR CARE 701 00:31:45,837 --> 00:31:49,474 TO HELP US AND MORE RESEARCH TO 702 00:31:49,540 --> 00:31:50,475 HELP SCHOOLS ADVOCATE US BETTER 703 00:31:50,541 --> 00:31:52,343 AND EXPECT MORE FROM US. 704 00:31:52,410 --> 00:31:55,313 I'M SURE WE ALL WANT THE PSALM 705 00:31:55,380 --> 00:31:55,613 THINGS. 706 00:31:55,680 --> 00:31:59,617 WE WANT PEOPLE WITH DOWN 707 00:31:59,684 --> 00:32:01,452 SYNDROME TO HAVE THE HIGHEST 708 00:32:01,519 --> 00:32:03,721 QUALITY OF LIFE. 709 00:32:03,788 --> 00:32:05,023 HIGH EXPECTATIONS FOR LEARNING, 710 00:32:05,089 --> 00:32:07,825 THE BEST MEDICAL CARE WE CAN GET 711 00:32:07,892 --> 00:32:09,427 AND WE WANT TO BE ABLE IMPORTANT 712 00:32:09,494 --> 00:32:13,564 MEMBERS OF OUR COMMUNITIES AND 713 00:32:13,631 --> 00:32:15,500 IMPROVE HOW PEOPLE THINK ABOUT 714 00:32:15,566 --> 00:32:18,436 HAVING DOWN SYNDROME AND WANT TO 715 00:32:18,503 --> 00:32:21,072 WORK AND HAVE FRIENDS. 716 00:32:21,139 --> 00:32:23,741 WE WANT TO FEEL IMPORTANT AND 717 00:32:23,808 --> 00:32:24,742 ACCEPTED. 718 00:32:24,809 --> 00:32:27,011 WE WANT TO LIVE LONG AND HAPPY 719 00:32:27,078 --> 00:32:27,312 LIVES. 720 00:32:27,378 --> 00:32:30,415 I HAVE A GREAT LIFE AND I'M 721 00:32:30,481 --> 00:32:34,419 THANKFUL TO ALL THE DOCTORS AND 722 00:32:34,485 --> 00:32:39,957 SCIENTISTS AND RESEARCHERS WHOSE 723 00:32:40,024 --> 00:32:47,365 WORK GOES TO THAT AND I RECEIVED 724 00:32:47,432 --> 00:32:51,135 AMAZING CARE AND I CAN DO BASIC 725 00:32:51,202 --> 00:32:54,172 MATH AND IMPROVED AT READING 726 00:32:54,238 --> 00:32:55,440 AND -- HOLD ON ONE SECOND, I'M 727 00:32:55,506 --> 00:32:58,743 SO SORRY. 728 00:32:58,810 --> 00:33:02,046 AND GOOD AT COMPUTERS AND I'M A 729 00:33:02,113 --> 00:33:03,848 LIFE LONG LEARNER. 730 00:33:03,915 --> 00:33:09,787 I WORK FULL TIME AT A JOB I LOVE 731 00:33:09,854 --> 00:33:14,125 AND I STAY ACTIVE IN RECREATION 732 00:33:14,192 --> 00:33:16,227 ACTION TESTS. 733 00:33:16,294 --> 00:33:19,764 SO, IN CLOSING, I KNOW THAT 734 00:33:19,831 --> 00:33:21,899 EVERYONE HERE IS EXCITED ABOUT 735 00:33:21,966 --> 00:33:23,768 THE FUTURE AND WHAT WE CAN DO. 736 00:33:23,835 --> 00:33:28,873 I HOPE YOU CAN GO HOME EVEN MORE 737 00:33:28,940 --> 00:33:30,441 EXCITED AFTER ATTENDING THIS 738 00:33:30,508 --> 00:33:31,042 CONFERENCE. 739 00:33:31,109 --> 00:33:32,844 FOR THOSE WHO ARE NEW TO THE 740 00:33:32,910 --> 00:33:35,546 WORLD OF DOWN SYNDROME, I SAY WE 741 00:33:35,613 --> 00:33:41,285 ARE A GREAT GROUP OF PEOPLE TO 742 00:33:41,352 --> 00:33:43,988 WORK WITH AND WORK WITH CHILDREN 743 00:33:44,055 --> 00:33:50,228 AND THOSE WIN TOWN SYNDROME. 744 00:33:50,294 --> 00:33:53,231 AND MY MOTHER ALWAYS SAID, AND 745 00:33:53,297 --> 00:34:03,841 STILL SAYS, IF SOMETHING'S WRONG 746 00:34:04,575 --> 00:34:07,111 AND I'M GRATEFUL IT MAKES ME WHO 747 00:34:07,178 --> 00:34:11,549 I AM TODAY. 748 00:34:11,616 --> 00:34:16,788 I AM EXCITED FOR ALL OF YOU TO 749 00:34:16,854 --> 00:34:19,090 GET TO DO AMAZING RESEARCH. 750 00:34:19,157 --> 00:34:22,059 THERE ARE SO MANY AREAS THAT 751 00:34:22,126 --> 00:34:23,528 STILL NEED TO BE ADDRESSED AND 752 00:34:23,594 --> 00:34:24,762 IT'S SO IMPORTANT FOR OUR 753 00:34:24,829 --> 00:34:25,196 QUALITY OF LIFE. 754 00:34:25,263 --> 00:34:28,166 YOU ARE MAKING SUCH A HUGE 755 00:34:28,232 --> 00:34:30,168 DIFFERENCE FOR SO MANY PEOPLE. 756 00:34:30,234 --> 00:34:32,737 YOU ARE MAKING LIFE BETTER FOR 757 00:34:32,804 --> 00:34:36,574 THE PEOPLE WHO ARE ALIVE NOW 758 00:34:36,641 --> 00:34:38,276 LIKE FOLKS MY AGE AND YOU'RE 759 00:34:38,342 --> 00:34:39,710 PREPARING THE WORLD FOR THE 760 00:34:39,777 --> 00:34:43,815 FUTURE BABIES WHO WILL BE BORN. 761 00:34:43,881 --> 00:34:47,518 YOUR RESEARCH WILL IMPROVE THEIR 762 00:34:47,585 --> 00:34:49,487 FUTURES COMPARED TO THOSE WHO 763 00:34:49,554 --> 00:34:51,489 CAME MANY YEARS BEFORE ME. 764 00:34:51,556 --> 00:34:53,925 THANK YOU FOR INVITING ME TO 765 00:34:53,991 --> 00:34:54,926 TALK TO YOU TODAY. 766 00:34:54,992 --> 00:34:56,394 I'M AROUND FOR ANY QUESTIONS IF 767 00:34:56,461 --> 00:34:58,396 YOU SEE ME IN THE HALLWAYS, I 768 00:34:58,463 --> 00:35:02,400 WANT TO THANK YOU FOR COMING TO 769 00:35:02,467 --> 00:35:04,435 THIS CONFERENCE TO LEARN MORE 770 00:35:04,502 --> 00:35:06,571 AND SO YOU GO HOME EMPOWERED AND 771 00:35:06,637 --> 00:35:09,006 READY TO TACKLE IMPORTANT WORK 772 00:35:09,073 --> 00:35:09,941 THAT NEEDS TO BE DONE TO HELP 773 00:35:10,007 --> 00:35:10,408 FOLKS LIKE ME. 774 00:35:10,475 --> 00:35:20,651 THANK YOU. 775 00:35:42,273 --> 00:35:43,708 >> THANK YOU SO MUCH, ISAIAH. 776 00:35:43,774 --> 00:35:46,410 I THINK WE'RE ALL INSPIRED BY 777 00:35:46,477 --> 00:35:47,812 YOUR WORDS AND YOUR CHARGE 778 00:35:47,879 --> 00:35:49,514 LEADING US IN THE CHARGE OF MORE 779 00:35:49,580 --> 00:35:50,414 RESEARCH FOR PEOPLE WITH DOWN 780 00:35:50,481 --> 00:35:50,681 SYNDROME. 781 00:35:50,748 --> 00:35:54,485 THANK YOU. 782 00:35:54,552 --> 00:35:58,623 NEXT I'D LIKE TO INTRODUCE A 783 00:35:58,689 --> 00:36:00,324 CO-PRESENTER -- SOMEBODY DID 784 00:36:00,391 --> 00:36:00,625 THAT FOR ME. 785 00:36:00,691 --> 00:36:02,393 WOW. 786 00:36:02,460 --> 00:36:04,028 OKAY. 787 00:36:04,095 --> 00:36:08,699 SO DR. ANNA MAZUKO WILL GIVE THE 788 00:36:08,766 --> 00:36:11,402 FIRST PART AND AIL GIVE THE 789 00:36:11,469 --> 00:36:11,636 SECOND. 790 00:36:11,702 --> 00:36:13,571 SHE'S A SENIOR ADVISER TO THE 791 00:36:13,638 --> 00:36:17,975 NIH DEPUTY DIRECTOR FOR PROGRAM 792 00:36:18,042 --> 00:36:20,545 COORDINATION, PLANNING AND 793 00:36:20,611 --> 00:36:22,547 STRATEGIC INITIATIVES. 794 00:36:22,613 --> 00:36:25,917 BEFORE JOINING DPCPSI SHE SERVED 795 00:36:25,983 --> 00:36:29,353 AS THE ACTING DEP UTILITIED 796 00:36:29,420 --> 00:36:30,354 DIRECTOR AND ADVISER FOR NIH 797 00:36:30,421 --> 00:36:31,822 WIDE ACTIVITIESTOWN THE OFFICE 798 00:36:31,889 --> 00:36:33,357 OF THE DIRECTOR HOLDING THE 799 00:36:33,424 --> 00:36:34,892 LATTER POSITION SINCE 2022. 800 00:36:34,959 --> 00:36:35,927 SHE'S BEEN WITH THE OFFICE OF 801 00:36:35,993 --> 00:36:39,897 THE DIRECTOR FOR A NUMBER OF 802 00:36:39,964 --> 00:36:42,433 YEARS AND WAS INVOLVED OF THE 803 00:36:42,500 --> 00:36:43,601 STRATEGIC PLAN FOR DIVERSITY, 804 00:36:43,668 --> 00:36:45,002 EQUITY, INCLUSION AND 805 00:36:45,069 --> 00:36:46,437 ACCESSIBILITY AND SEARCHED AS 806 00:36:46,504 --> 00:36:49,040 THE DEPUTY DIRECTOR OF THE NIH 807 00:36:49,106 --> 00:36:51,142 HEAL INITIATIVE HELPING TO END 808 00:36:51,208 --> 00:36:52,710 ADDITION LONG TERM. 809 00:36:52,777 --> 00:36:55,580 SHE'S BEEN VERY INVOLVED IN THE 810 00:36:55,646 --> 00:36:56,847 COORDINATION AND LAUNCH OF THE 811 00:36:56,914 --> 00:36:59,517 INCLUDE INITIATIVE AND ONE OF MY 812 00:36:59,584 --> 00:37:01,953 PARTNERS IN CRIME FOR THE 813 00:37:02,019 --> 00:37:02,687 ACTIVITY AND A WOULD WELCOME 814 00:37:02,753 --> 00:37:11,862 DR. MAZZUCCO TO TELL US ABOUT 815 00:37:11,929 --> 00:37:14,465 THE FIVE YEARS OF 816 00:37:14,532 --> 00:37:24,375 TRANSFORMATION. 817 00:37:24,442 --> 00:37:24,976 >> THANK YOU. 818 00:37:25,042 --> 00:37:28,512 IT'S MY PLEASURE GIVE THIS 819 00:37:28,579 --> 00:37:29,513 PRESENTATION WITH MY DEAR 820 00:37:29,580 --> 00:37:30,681 COLLEAGUE, MELISSA. 821 00:37:30,748 --> 00:37:33,651 WE'VE BEEN PARTNERS IN CRIME 822 00:37:33,718 --> 00:37:35,653 SINCE THE LAUNCH OF INCLUDE WITH 823 00:37:35,720 --> 00:37:37,188 A TEAM OF FOLKS ACROSS NIH 824 00:37:37,254 --> 00:37:38,055 WORKING TOGETHER ON DOWN 825 00:37:38,122 --> 00:37:38,322 SYNDROME. 826 00:37:38,389 --> 00:37:40,524 SO WE'D LIKE TO JUST TAKE THIS 827 00:37:40,591 --> 00:37:44,996 MOMENT TO GIVE YOU JUST A LITTLE 828 00:37:45,062 --> 00:37:46,797 HISTORY AS WE ENTER THE NEXT 829 00:37:46,864 --> 00:37:49,266 PHASE OF INCLUDE AND THINK ABOUT 830 00:37:49,333 --> 00:37:50,167 ITS FUTURE TOGETHER. 831 00:37:50,234 --> 00:37:52,603 SO A LITTLE BACKGROUND ON WHAT 832 00:37:52,670 --> 00:37:54,972 KIND OF STARTED ALL THIS WORK AS 833 00:37:55,039 --> 00:37:57,174 MOST OF YOU KNOW, EACH YEAR 834 00:37:57,241 --> 00:37:59,343 THERE'S ABOUT 6,000 BABIES IN 835 00:37:59,410 --> 00:38:01,245 THE UNITED STATES BORN WITH DOWN 836 00:38:01,312 --> 00:38:03,648 SYNDROME AFFECTING APPROXIMATELY 837 00:38:03,714 --> 00:38:05,783 ONE IN EVERY 700 BABIES. 838 00:38:05,850 --> 00:38:09,186 AND IN PARTICULAR BECAUSE OF 839 00:38:09,253 --> 00:38:10,521 THAT RESULTED IN BETTER 840 00:38:10,588 --> 00:38:14,191 TREATMENT FOR BABIES BORN WITH 841 00:38:14,258 --> 00:38:19,997 DOWN SYNDROME THE AVERAGE LIFE 842 00:38:20,064 --> 00:38:25,536 SPAN DOUBLED FROM 30 TO 60 YE 843 00:38:25,603 --> 00:38:25,736 YEARS. 844 00:38:25,803 --> 00:38:28,673 THEY'RE LIKELY TO ALZHEIMER'S 845 00:38:28,739 --> 00:38:30,241 DISEASE WHILE BEING PROTECTED TO 846 00:38:30,307 --> 00:38:30,808 FORMS OF CANCER. 847 00:38:30,875 --> 00:38:32,276 FOR THIS REASON, AS THE AN 848 00:38:32,343 --> 00:38:34,545 INCREASING NEED AS YOU ALL KNOW 849 00:38:34,612 --> 00:38:36,213 FOR RESEARCH FOCUSSING ON 850 00:38:36,280 --> 00:38:38,049 QUALITY OF LIFE NEEDS FOR 851 00:38:38,115 --> 00:38:38,683 INDIVIDUALS WITH DOWN SYNDROME 852 00:38:38,749 --> 00:38:42,319 ACROSS THEIR LIVES. 853 00:38:42,386 --> 00:38:45,222 SO I WANT TO JUST TAKE A STEP 854 00:38:45,289 --> 00:38:47,591 BACK AND TALK A LITTLE BIT ABOUT 855 00:38:47,658 --> 00:38:49,026 NIH HISTORY AS WE'VE COME TO 856 00:38:49,093 --> 00:38:51,195 LEARN MORE ABOUT DOWN SYNDROME 857 00:38:51,262 --> 00:38:53,297 AND SEE THE RESEARCH GROW OVER 858 00:38:53,364 --> 00:38:53,964 THE YEARS. 859 00:38:54,031 --> 00:38:56,801 THIS IS A LITTLE BIT OF A 860 00:38:56,867 --> 00:38:59,670 SNAPSHOT WHERE WE WERE SIX YEARS 861 00:38:59,737 --> 00:39:02,940 AGO WHEN NIH LAUNCHED THE 862 00:39:03,007 --> 00:39:04,942 INCLUDE PROJECT AND OUR TEAM, 863 00:39:05,009 --> 00:39:07,545 MANY OF WHOM SUCH AS MELISSA 864 00:39:07,611 --> 00:39:09,180 HAVE BEEN WORKING ON INCLUDE 865 00:39:09,246 --> 00:39:11,916 SINCE IT BEGAN. 866 00:39:11,982 --> 00:39:17,788 SO IN 2005, THE NICHD DEPUTY 867 00:39:17,855 --> 00:39:20,157 DIRECTOR LAUNCHED THE FIRST NIH 868 00:39:20,224 --> 00:39:22,727 WIDE DOWN SYNDROME WORKING GROUP 869 00:39:22,793 --> 00:39:28,699 WHICH WAS COMPOSED OF SEVERAL 870 00:39:28,766 --> 00:39:29,533 INSTITUTES FROM ACROSS NIH YOU 871 00:39:29,600 --> 00:39:30,968 SEE LISTED HERE AND THE GROUP 872 00:39:31,035 --> 00:39:35,806 WAS TASKED BY OUR PREVIOUS 873 00:39:35,873 --> 00:39:37,575 DIRECTOR TO DEVELOP A RESEARCH 874 00:39:37,641 --> 00:39:43,314 PLAN FOR DOWN SYNDROME IN FY2007 875 00:39:43,380 --> 00:39:47,318 FOCUSSING ON COGNITION AND OTHER 876 00:39:47,384 --> 00:39:48,886 HEALTH-RELATED ISSUES FOR DOWN 877 00:39:48,953 --> 00:39:49,153 SYNDROME. 878 00:39:49,220 --> 00:39:52,590 THIS IS THE HISTORY OF THE WORK 879 00:39:52,656 --> 00:39:54,725 AT NIH AND WHERE WE STARTED WHEN 880 00:39:54,792 --> 00:39:57,995 INCLUDE FIRST CAME INTO BEING. 881 00:39:58,062 --> 00:40:01,532 YOU CAN SEE NIH HAD A DOWN 882 00:40:01,599 --> 00:40:02,233 SYNDROME RESEARCH PLAN. 883 00:40:02,299 --> 00:40:05,202 THE FIRST ON THE LEFT WAS 884 00:40:05,269 --> 00:40:07,371 LAUNCHED IN OCTOBER 2007 AROUND 885 00:40:07,438 --> 00:40:09,774 THE TIME THAT THE NIH DOWN 886 00:40:09,840 --> 00:40:11,208 SYNDROME WORKING GROUP WAS 887 00:40:11,275 --> 00:40:11,442 STARTED. 888 00:40:11,509 --> 00:40:16,313 AND REALLY THE POINT HERE IS 889 00:40:16,380 --> 00:40:17,481 THAT ACROSS THE YEAR THINKING 890 00:40:17,548 --> 00:40:18,916 ABOUT DOWN SYNDROME RESEARCH AT 891 00:40:18,983 --> 00:40:21,886 NIH WE WANTED TO TAKE A 892 00:40:21,952 --> 00:40:22,753 THOUGHTFUL APPROACH AND 893 00:40:22,820 --> 00:40:24,889 STRATEGIC APPROACH TO ENSURE WE 894 00:40:24,955 --> 00:40:27,191 HAVE A COHESIVE FRAMEWORK FOR 895 00:40:27,258 --> 00:40:29,660 THINKING ABOUT DOWN SYNDROME, 896 00:40:29,727 --> 00:40:31,729 SETTING OUR RESEARCH PRIORITIES 897 00:40:31,796 --> 00:40:33,430 AND MAKE SURE IT'S A 898 00:40:33,497 --> 00:40:34,965 COLLABORATIVE EFFORT THAT BRINGS 899 00:40:35,032 --> 00:40:38,402 TO BEAR ALL OF NIH'S STRENGTHS 900 00:40:38,469 --> 00:40:39,537 AND EXPERTISE IN THIS AREA. 901 00:40:39,603 --> 00:40:42,206 YOU CAN SEE IN THE MIDDLE WE HAD 902 00:40:42,273 --> 00:40:44,341 ANOTHER RESEARCH PLAN IN 2017 903 00:40:44,408 --> 00:40:48,279 AND THEN I'M PLEASED TO SHOW ON 904 00:40:48,345 --> 00:40:54,418 THE RIGHT OUR MOST RECENT DOWN 905 00:40:54,485 --> 00:40:55,719 SYNDROME RESEARCH PLAN WHICH 906 00:40:55,786 --> 00:40:57,021 INCLUDES RESEARCH ACTIVITIES 907 00:40:57,087 --> 00:40:58,689 RELEASED IN 2022. 908 00:40:58,756 --> 00:41:03,828 I WANTED TO MENTION ONE THING 909 00:41:03,894 --> 00:41:05,529 THAT WAS IMPORTANT TO US TO HAVE 910 00:41:05,596 --> 00:41:07,565 PUBLIC INPUT INTO THE RESEARCH 911 00:41:07,631 --> 00:41:11,769 MAN'S TO CAPTURE THE NEEDS OF 912 00:41:11,836 --> 00:41:14,605 THE COMMUNITY AND THOUGHTS OF 913 00:41:14,672 --> 00:41:15,206 RESEARCHERS. 914 00:41:15,272 --> 00:41:17,341 THE 2022 PLAN IS AVAILABLE ON 915 00:41:17,408 --> 00:41:18,175 OUR INCLUDE WEBSITE. 916 00:41:18,242 --> 00:41:19,710 YOU CAN SEE THE LINK RIGHT 917 00:41:19,777 --> 00:41:20,311 THERE. 918 00:41:20,377 --> 00:41:23,180 AND I WANT TO MENTION OF COURSE 919 00:41:23,247 --> 00:41:24,114 SOMETHING WE KNOW. 920 00:41:24,181 --> 00:41:27,151 I THINK AS IS TRUE IN LIFE 921 00:41:27,218 --> 00:41:27,751 GENERALLY, SOMETHING SO 922 00:41:27,818 --> 00:41:28,853 IMPORTANT TO DO TOGETHER. 923 00:41:28,919 --> 00:41:30,988 WE KNOW WE CAN'T DO THIS ALONE. 924 00:41:31,055 --> 00:41:36,360 AND SO NIH HAS BEEN VERY PLEASED 925 00:41:36,427 --> 00:41:42,099 TO TO CONTINUE TO WORK ON DOWN 926 00:41:42,166 --> 00:41:45,069 SYNDROME WITH RESEARCHERS AND 927 00:41:45,135 --> 00:41:46,270 ADVOCACY ORGANIZATIONS TO MAKE 928 00:41:46,337 --> 00:41:48,639 SURE WE UNDERSTAND THE NEEDS OF 929 00:41:48,706 --> 00:41:50,808 THE COMMUNITY AND THAT THEY ARE 930 00:41:50,875 --> 00:41:51,375 REALLY INFORMING WHERE THE 931 00:41:51,442 --> 00:41:54,745 SCIENCE GOES. 932 00:41:54,812 --> 00:41:58,315 SO WE'RE VERY PLEASED THE DOWN 933 00:41:58,382 --> 00:42:02,019 SYNDROME CONSORTIUM WHICH WAS 934 00:42:02,086 --> 00:42:05,556 BEGUN IN 2011 REGULARLY MEETS 935 00:42:05,623 --> 00:42:09,526 WITH 13 NIH INSTITUTES 936 00:42:09,593 --> 00:42:11,128 PARTICIPATING, 17 PROFESSIONAL 937 00:42:11,195 --> 00:42:11,762 ORGANIZATIONS, ADVOCACY GROUPS 938 00:42:11,829 --> 00:42:13,964 AND FOUNDATIONS AND THREE 939 00:42:14,031 --> 00:42:14,331 SELF-ADVOCATES. 940 00:42:14,398 --> 00:42:16,100 YOU CAN SEE ALL THE MEMBERS 941 00:42:16,166 --> 00:42:18,135 LISTED HERE AND THE CONSORTIUM 942 00:42:18,202 --> 00:42:20,671 HAS PROVIDED CRITICAL INPUT INTO 943 00:42:20,738 --> 00:42:22,139 THE DOWN SYNDROME RESEARCH PLANS 944 00:42:22,206 --> 00:42:27,745 AS SHOWN ON THE PREVIOUS SLIDE. 945 00:42:27,811 --> 00:42:30,481 AND THIS SLIDE, THIS ONE SPEAKS 946 00:42:30,547 --> 00:42:33,317 FOR ITSELF, I THINK, BECAUSE 947 00:42:33,384 --> 00:42:35,286 FRANK DID BETTER THAN ANY OF US 948 00:42:35,352 --> 00:42:38,555 COULD IS BUT AS DR. BIANCHI 949 00:42:38,622 --> 00:42:43,527 MENTIONED, IN 2017, IT WAS HIS 950 00:42:43,594 --> 00:42:44,194 TESTIMONY ABOUT CONGRESS WHICH 951 00:42:44,261 --> 00:42:46,664 GAVE US THE RESOURCES WE HAVE 952 00:42:46,730 --> 00:42:49,233 TODAY AND IS WHY WE'RE REALLY 953 00:42:49,300 --> 00:42:51,802 ALL HERE AND INCLUDE WAS ABLE TO 954 00:42:51,869 --> 00:42:54,438 LAUNCH THE FOLLOWING FISCAL YEAR 955 00:42:54,505 --> 00:42:59,610 IN 2018. 956 00:42:59,677 --> 00:43:02,479 SO LASTLY AS YOU HEARD FROM 957 00:43:02,546 --> 00:43:04,415 DR. BIANCHI WHEN WE RECEIVED THE 958 00:43:04,481 --> 00:43:09,386 ADDITIONAL RESOURCES FROM 959 00:43:09,453 --> 00:43:11,121 CONGRESS, THE DOWN SYNDROME 960 00:43:11,188 --> 00:43:16,427 WORKING GROUP WHO HAD BEEN 961 00:43:16,493 --> 00:43:26,937 WORKING TOGETHER ON DOWN 962 00:43:30,107 --> 00:43:31,041 SYNDROME FROM CONGRESS AND WHAT 963 00:43:31,108 --> 00:43:33,043 I HOPE YOU'LL HEAR AS THEMES FOR 964 00:43:33,110 --> 00:43:34,011 TODAY AND TOMORROW'S 965 00:43:34,078 --> 00:43:35,045 DISCUSSIONS, THE GOALS OF THE 966 00:43:35,112 --> 00:43:38,415 INCLUDE PROJECT REALLY ARE TO 967 00:43:38,482 --> 00:43:40,951 INVESTIGATE CONDITIONS THAT 968 00:43:41,018 --> 00:43:41,852 AFFECT INDIVIDUALS WITH DOWN 969 00:43:41,919 --> 00:43:44,388 SYNDROME AND THE GENERAL 970 00:43:44,455 --> 00:43:45,522 POPULATION SUCH AS ALZHEIMER'S 971 00:43:45,589 --> 00:43:50,361 DISEASE, AUTISM, CATARACTS, 972 00:43:50,427 --> 00:43:52,396 CELIAC DISEASE AND CONGENITAL 973 00:43:52,463 --> 00:43:53,530 HEART DISEASE AND DIABETES. 974 00:43:53,597 --> 00:43:55,532 INCREASE THE NUMBER OF 975 00:43:55,599 --> 00:43:57,201 INVESTIGATORS AND TRAINEES 976 00:43:57,267 --> 00:43:59,336 STUDYING DOWN SYNDROME, ENGAGE 977 00:43:59,403 --> 00:44:01,038 WITH THOSE WITH DOWN SYNDROME 978 00:44:01,105 --> 00:44:03,440 AND THEIR FAMILIES FROM DIVERSE 979 00:44:03,507 --> 00:44:06,410 BACKGROUNDS TO PARTICIPATE IN 980 00:44:06,477 --> 00:44:10,681 ONGOING RESEARCH. 981 00:44:10,748 --> 00:44:13,684 INCLUDE APPLIES EXPERTISE AND 982 00:44:13,751 --> 00:44:16,553 RESOURCES FROM ACROSS 18 NIH 983 00:44:16,620 --> 00:44:17,421 INSTITUTES AND CENTER TO 984 00:44:17,488 --> 00:44:19,356 COLLABORATIVELY ADVANCE THE 985 00:44:19,423 --> 00:44:19,990 CURRENT STATE OF DOWN SYNDROME 986 00:44:20,057 --> 00:44:23,193 SCIENCE. 987 00:44:23,260 --> 00:44:25,095 THE INCLUDE PROJECT IS DIVIDED 988 00:44:25,162 --> 00:44:27,498 INTO THREE COMPONENTS INCLUDING 989 00:44:27,564 --> 00:44:30,401 TARGETED HIGH RISK DISCOVERY 990 00:44:30,467 --> 00:44:32,903 SCIENCE FOCUSSING ON THE BIOLOGY 991 00:44:32,970 --> 00:44:35,039 OF CHROMOSOME 21, BUILDING A 992 00:44:35,105 --> 00:44:37,307 LARGE COHORT OF INDIVIDUALS WITH 993 00:44:37,374 --> 00:44:41,412 DOWN SYNDROME FOR COMPREHENSIVE 994 00:44:41,478 --> 00:44:42,479 ANALYSIS AND BIOMARKER 995 00:44:42,546 --> 00:44:44,882 EVALUATION AND INCLUDING 996 00:44:44,948 --> 00:44:45,582 INDIVIDUALS WITH DOWN SYNDROME 997 00:44:45,649 --> 00:44:49,353 AND EXISTING AND FUTURE COHORTS. 998 00:44:49,420 --> 00:44:54,358 -- CLINICAL TRIALS. 999 00:44:54,425 --> 00:45:00,931 I WANT TO JUST MENTION THIS 1000 00:45:00,998 --> 00:45:02,933 STARTED FROM ADDITIONAL 1001 00:45:03,000 --> 00:45:04,201 RESOURCES FROM CONGRESS AND AS 1002 00:45:04,268 --> 00:45:05,903 DR. BIANCHI SAID THE RESOURCES 1003 00:45:05,969 --> 00:45:07,037 HAVE CONTINUED TO GROW SO WE'RE 1004 00:45:07,104 --> 00:45:08,605 EXTREMELY GRATEFUL FOR THE 1005 00:45:08,672 --> 00:45:14,445 SUPPORT FROM CONGRESS AND OUR 1006 00:45:14,511 --> 00:45:21,418 COMMUNITY TO CONTINUE TO BUILD 1007 00:45:21,485 --> 00:45:26,423 THE RESEARCH AND SEE WHAT 1008 00:45:26,490 --> 00:45:29,960 STARTED OFF IN 2018 ONE $23 1009 00:45:30,027 --> 00:45:30,928 MILLION OF RESOURCES FROM 1010 00:45:30,994 --> 00:45:33,363 CONGRESS HAS GROWN TO WHERE WE 1011 00:45:33,430 --> 00:45:38,402 ARE IN 2023 WITH $90 MILLION IN 1012 00:45:38,469 --> 00:45:41,004 FUNDING SPECIFICALLY FOR THE 1013 00:45:41,071 --> 00:45:42,739 INCLUDE PROJECT. 1014 00:45:42,806 --> 00:45:46,110 AT THE NIH TO DATE OVER THE LAST 1015 00:45:46,176 --> 00:45:48,946 FIVE YEARS INCLUDE HAS INVESTED 1016 00:45:49,012 --> 00:45:51,281 $348 MILLION OVER THE PAST SIX 1017 00:45:51,348 --> 00:45:53,383 YEAR ON 330 PROJECTS FOR THE 1018 00:45:53,450 --> 00:46:02,059 INCLUDE INITIATIVE ALONE. 1019 00:46:02,126 --> 00:46:07,598 WE'VE RELEASED PROJECTS AND THE 1020 00:46:07,664 --> 00:46:09,199 MAJORITY OF INCLUDE FUNDS HAVE 1021 00:46:09,266 --> 00:46:13,137 SUPPORTED HIGH-RISK DISCOVERY 1022 00:46:13,203 --> 00:46:14,571 PROJECTS AND CLINICAL TRIALS AND 1023 00:46:14,638 --> 00:46:17,674 THE NUMBER OF CLINICAL STUDIES 1024 00:46:17,741 --> 00:46:19,376 AND CLINICAL TRIALS SUPPORTED BY 1025 00:46:19,443 --> 00:46:21,278 INCLUDE HAS INCREASED EVERY YEAR 1026 00:46:21,345 --> 00:46:24,648 OF THE PROGRAM. 1027 00:46:24,715 --> 00:46:26,817 SO LASTLY JUST A FEW MORE 1028 00:46:26,884 --> 00:46:28,485 SNAPSHOTS OF WHERE WE ARE BEFORE 1029 00:46:28,552 --> 00:46:31,054 I TURN IT OVER TO MELISSA, AS I 1030 00:46:31,121 --> 00:46:35,859 SAID, WE'VE NOW FUNDED 330 1031 00:46:35,926 --> 00:46:37,728 PROJECTS, 50 FUNDING 1032 00:46:37,794 --> 00:46:42,399 OPPORTUNITIES, ALMOST 250 1033 00:46:42,466 --> 00:46:42,733 PUBLICATIONS. 1034 00:46:42,799 --> 00:46:46,403 WE MAINTAIN 18 INSTITUTES AND 1035 00:46:46,470 --> 00:46:48,772 CENTERS ACROSS NIH COLLABORATING 1036 00:46:48,839 --> 00:46:49,673 ON INCLUDE. 1037 00:46:49,740 --> 00:46:54,978 13 CLINICAL TRIALS, A DATA 1038 00:46:55,045 --> 00:46:55,979 COORDINATING CENTER AND 13 1039 00:46:56,046 --> 00:46:57,314 INCLUDE HOSTED COMMUNITY 1040 00:46:57,381 --> 00:47:01,485 ENGAGEMENT AND OUTREACH EVENTS. 1041 00:47:01,552 --> 00:47:02,953 THANK YOU SO MUCH FOR COMING AND 1042 00:47:03,020 --> 00:47:07,658 NOW I'LL HAND IT OVER TO MY DEAR 1043 00:47:07,724 --> 00:47:08,926 COLLEAGUE, MELISSA, TO TALK MORE 1044 00:47:08,992 --> 00:47:09,860 ABOUT THE ACCOMPLISHMENTS OF 1045 00:47:09,927 --> 00:47:10,727 INCLUDE YOU HAVE GIVEN US TODAY. 1046 00:47:10,794 --> 00:47:19,303 THANK YOU VERY MUCH. 1047 00:47:19,369 --> 00:47:23,006 >> THANK YOU, ANNA. 1048 00:47:23,073 --> 00:47:26,276 I REALIZE I CAN'T DO ALL THE PJZ 1049 00:47:26,343 --> 00:47:27,010 JUSTICE SO IT WILL BE MORE LIKE 1050 00:47:27,077 --> 00:47:30,414 A TEASER AND THE PEOPLE WHO HAVE 1051 00:47:30,480 --> 00:47:33,283 DOING THE RESEARCH ARE GIVING 1052 00:47:33,350 --> 00:47:35,786 PRESENTATIONS TODAY AND TOMORROW 1053 00:47:35,852 --> 00:47:37,554 AND GET MORE A VIEW OF THE 1054 00:47:37,621 --> 00:47:38,622 ACCOMPLISHMENTS THUS FAR. 1055 00:47:38,689 --> 00:47:40,791 WE'RE STILL IN EARLY DAYS BUT 1056 00:47:40,857 --> 00:47:42,459 EXCITED ABOUT WHAT WE LEARN AND 1057 00:47:42,526 --> 00:47:42,726 LEARN. 1058 00:47:42,793 --> 00:47:44,761 THERE'S BEEN STUDIES THAT LOOKED 1059 00:47:44,828 --> 00:47:47,297 AT THE IMPACT OF COVID-19 ON 1060 00:47:47,364 --> 00:47:49,199 INDIVIDUALS WITH DOWN SYNDROME 1061 00:47:49,266 --> 00:47:50,767 ESPECIALLY THOSE WHO HAVE HAD 1062 00:47:50,834 --> 00:47:54,438 MORE SEVERE MANIFESTATIONS OF 1063 00:47:54,504 --> 00:47:56,840 THE CONDITION. 1064 00:47:56,907 --> 00:47:59,943 AS YOU HEARD FROM DR. BIANCHI 1065 00:48:00,010 --> 00:48:03,947 HOME SLEEP STUDIES COULD 1066 00:48:04,014 --> 00:48:06,083 REVOLUTIONIZE RESEARCH AND 1067 00:48:06,149 --> 00:48:08,685 THERE'S A WAY TO MEASURE VISUAL 1068 00:48:08,752 --> 00:48:10,954 ACUITY AND THE DOSAGE OF GENES 1069 00:48:11,021 --> 00:48:13,223 ON CHROMOSOME 21 AND HOW THEY 1070 00:48:13,290 --> 00:48:15,759 IMPACT THE FEATURES ON AN 1071 00:48:15,826 --> 00:48:16,126 INDIVIDUAL. 1072 00:48:16,193 --> 00:48:18,862 THERE'S BEEN WORKING AT 1073 00:48:18,929 --> 00:48:20,297 COGNITIVE MEASURES AND TRYING TO 1074 00:48:20,364 --> 00:48:22,466 USE THE NIH TOOL BOX AND OTHER 1075 00:48:22,532 --> 00:48:24,268 TOOLS TO BETTER UNDERSTAND 1076 00:48:24,334 --> 00:48:26,436 BEHAVIOR AND DEVELOPMENT IN DOWN 1077 00:48:26,503 --> 00:48:28,405 SYNDROME INCLUDING THE BEHAVIOR 1078 00:48:28,472 --> 00:48:30,674 INVENTORY OR BIDS THAT'S BEEN 1079 00:48:30,741 --> 00:48:30,941 DEVELOPED. 1080 00:48:31,008 --> 00:48:33,110 WE HAVE ALSO BEEN STUDIES MANY 1081 00:48:33,176 --> 00:48:35,779 OF THE GENES ASSOCIATED WITH 1082 00:48:35,846 --> 00:48:38,815 CONGENITAL HEART DISEASE IN 1083 00:48:38,882 --> 00:48:40,250 INFANTS BORN WITH DOWN SYNDROME 1084 00:48:40,317 --> 00:48:44,788 AND FUNDING ONGOING STUDIES 1085 00:48:44,855 --> 00:48:47,190 THROUGH THE ALZHEIMER'S 1086 00:48:47,257 --> 00:48:48,759 BIOMARKERS CONSORTIUM DOWN 1087 00:48:48,825 --> 00:48:51,161 SYNDROME PROJECT YOU HEARD A BIT 1088 00:48:51,228 --> 00:48:52,863 ABOUT FROM DR. BIANCHI WITH 92 1089 00:48:52,929 --> 00:48:54,164 INVESTIGATORS ACROSS 19 1090 00:48:54,231 --> 00:48:55,265 INSTITUTIONS AND SOME RESEARCH 1091 00:48:55,332 --> 00:48:57,267 FUNDED BY THE GROUP SHOWN IN THE 1092 00:48:57,334 --> 00:48:59,536 PICTURE STARTING TO SHED LIGHT 1093 00:48:59,603 --> 00:49:00,804 ON THE NEURAL PATHOLOGY AND 1094 00:49:00,871 --> 00:49:03,106 DISEASE PROGRESSION AND 1095 00:49:03,173 --> 00:49:04,107 THERAPIES SPECIFIC FOR DOWN 1096 00:49:04,174 --> 00:49:04,374 SYNDROME. 1097 00:49:04,441 --> 00:49:05,042 YOU KNOW YOU'LL HEAR MORE LATER 1098 00:49:05,108 --> 00:49:08,378 ON. 1099 00:49:08,445 --> 00:49:10,414 WITH REGARD TO DATA SUPPORT AND 1100 00:49:10,480 --> 00:49:12,382 DATA MANAGEMENT, WE'RE VERY 1101 00:49:12,449 --> 00:49:14,751 PLEASED WITH THE PROGRESS OF THE 1102 00:49:14,818 --> 00:49:16,053 INCLUDE DATA COORDINATING 1103 00:49:16,119 --> 00:49:17,220 CENTER, WHICH IS REALLY 1104 00:49:17,287 --> 00:49:19,756 DEVELOPING AN ECO SYSTEM TO 1105 00:49:19,823 --> 00:49:21,291 SUPPORT DOWN SYNDROME RELATED 1106 00:49:21,358 --> 00:49:21,591 RESEARCH. 1107 00:49:21,658 --> 00:49:25,295 IN MANY WAYS IT'S SERVING AS A 1108 00:49:25,362 --> 00:49:27,331 MODEL FOR WAYS TO PROMOTE DATA 1109 00:49:27,397 --> 00:49:30,701 ACQUISITION AND SHARING AND 1110 00:49:30,767 --> 00:49:32,302 REUSE ACROSS THE NIH BASED ON 1111 00:49:32,369 --> 00:49:32,969 FOCUSSING ON DOWN SYNDROME HAS A 1112 00:49:33,036 --> 00:49:35,939 STARTING POINT. 1113 00:49:36,006 --> 00:49:39,509 THE DCC IS SUPPORTING DATA 1114 00:49:39,576 --> 00:49:42,346 COLLECTED FROM DS CONNECT THE 1115 00:49:42,412 --> 00:49:42,913 DOWN SYNDROME REGISTRY. 1116 00:49:42,979 --> 00:49:46,750 IT'S SUPPORTING RESEARCH 1117 00:49:46,817 --> 00:49:51,088 COLLECTED THROUGH THE TYSOM 1118 00:49:51,154 --> 00:49:52,489 EXPLORE AND IT'S A USEFUL TOOL 1119 00:49:52,556 --> 00:49:54,758 TO LEARN ABOUT PUBLICATIONS AND 1120 00:49:54,825 --> 00:49:56,560 GRANTS FUNDED THROUGH INCLUDE 1121 00:49:56,626 --> 00:49:59,429 AND THE DATA HUB ITSELF IS THE 1122 00:49:59,496 --> 00:50:00,864 PORTAL THAT GIVES ACCESS TO THE 1123 00:50:00,931 --> 00:50:03,100 DATA AND THE DATA ARE FREELY 1124 00:50:03,166 --> 00:50:05,902 AVAILABLE WITH REGISTRATION FOR 1125 00:50:05,969 --> 00:50:07,371 THE PROEPT MORE SECURE ASPECTS 1126 00:50:07,437 --> 00:50:07,771 OF THE DATA. 1127 00:50:07,838 --> 00:50:13,477 AND AS YOU HEARD FROM 1128 00:50:13,543 --> 00:50:15,312 DR. BIANCHI IT WILL HELP US TRY 1129 00:50:15,379 --> 00:50:17,214 TO INTEGRATE HUMAN DATA WITH 1130 00:50:17,280 --> 00:50:20,183 DATA FROM MODELS, ANIMAL AND 1131 00:50:20,250 --> 00:50:21,585 CELLULAR MODELS AND TISSUE-BASED 1132 00:50:21,651 --> 00:50:21,985 MODELS. 1133 00:50:22,052 --> 00:50:26,590 WE'RE VERY EXCITE ABOUT ALL THIS 1134 00:50:26,656 --> 00:50:32,829 PROGRESS BEING MADE. 1135 00:50:32,896 --> 00:50:36,533 THE MULTI-DIMENSIONAL DATA SETS 1136 00:50:36,600 --> 00:50:41,505 AND A SAMPLING OF THE 11 STUDY 1137 00:50:41,571 --> 00:50:44,908 THAT HAVE THEIR DATA ENTERED IN 1138 00:50:44,975 --> 00:50:48,011 THE DCC AND OVER 9,000 RESEARCH 1139 00:50:48,078 --> 00:50:54,418 PARTICIPANTS AND OVER 7500 WITH 1140 00:50:54,484 --> 00:50:58,422 DOWN SYNDROME AND TRISOM21 AND 1141 00:50:58,488 --> 00:50:58,989 HAVE DOWN SYNDROME RELATED 1142 00:50:59,055 --> 00:51:07,664 RESEARCH. 1143 00:51:07,731 --> 00:51:09,199 THERE'S CLINICAL PROFILES AS 1144 00:51:09,266 --> 00:51:10,167 MENTIONED FROM ALL THE 1145 00:51:10,233 --> 00:51:11,835 PARTICIPANTS THE HUMAN 1146 00:51:11,902 --> 00:51:14,404 PARTICIPANTS AND THERE ARE OVER 1147 00:51:14,471 --> 00:51:18,408 4,000 GENOMES AND OVER 1700 1148 00:51:18,475 --> 00:51:21,211 TRANSCRIPTOMES AND OVER 470 1149 00:51:21,278 --> 00:51:23,180 PROTEOMES AND OVER 400 1150 00:51:23,246 --> 00:51:23,480 METABOLOMES. 1151 00:51:23,547 --> 00:51:26,383 FOR THOSE IN DATA SCIENCE, THIS 1152 00:51:26,450 --> 00:51:28,185 IS A TREASURE TROVE OF TEFRL AND 1153 00:51:28,251 --> 00:51:29,886 INFORMATION THAT WILL HELP US 1154 00:51:29,953 --> 00:51:32,956 UNDERSTAND IN GREATER DETAIL 1155 00:51:33,023 --> 00:51:34,858 WHAT IS ACTUALLY HAPPENING IN 1156 00:51:34,925 --> 00:51:36,560 DOWN SYNDROME FOR INDIVIDUALS 1157 00:51:36,626 --> 00:51:37,561 AND POTENTIAL THERAPEUTIC 1158 00:51:37,627 --> 00:51:39,329 TARGETS FOR HOW TO IMPROVE 1159 00:51:39,396 --> 00:51:40,664 QUALITY OF LIFE FOR PEOPLE WITH 1160 00:51:40,730 --> 00:51:41,264 DOWN SYNDROME. 1161 00:51:41,331 --> 00:51:44,768 STAY TUNED BECAUSE EPIGENOMES 1162 00:51:44,835 --> 00:51:47,804 AND IMMUNE MAPS AND WE'LL COVER 1163 00:51:47,871 --> 00:51:51,908 ALL THE OMES BY THE TIME WE'RE 1164 00:51:51,975 --> 00:51:52,742 DONE. 1165 00:51:52,809 --> 00:51:54,778 PIVOTING , I WANT TO HIGHLIGHT 1166 00:51:54,845 --> 00:51:56,513 THE IMPORTANT WORK IN THE 1167 00:51:56,580 --> 00:51:57,914 TRAINING SPACE FOR THE INCLUDE 1168 00:51:57,981 --> 00:51:58,181 PROJECT. 1169 00:51:58,248 --> 00:52:00,317 AS DR. BIANCHI MENTIONED WE WANT 1170 00:52:00,383 --> 00:52:03,019 TO INCREASE THE NUMBER OF JUNIOR 1171 00:52:03,086 --> 00:52:05,288 OR EARLY CAREER INVESTIGATORS 1172 00:52:05,355 --> 00:52:06,523 WHO CHOOSE A CAREER IN DOWN 1173 00:52:06,590 --> 00:52:08,458 SYNDROME RELATED RESEARCH. 1174 00:52:08,525 --> 00:52:10,427 THUS FAR UNDER INCLUDE RELATED 1175 00:52:10,494 --> 00:52:12,996 GRANTS AND AWARDS WE SUPPORTED 1176 00:52:13,063 --> 00:52:17,701 40 TRAINEES INCLUDING T-32 AND 1177 00:52:17,767 --> 00:52:20,504 PEDIATRIC HEART NETWORK FELLOWS 1178 00:52:20,570 --> 00:52:28,178 AND INDIVIDUAL F31, KO8 AND K33 1179 00:52:28,245 --> 00:52:30,614 AAWARDEES AND THE DOWN SYNDROME 1180 00:52:30,680 --> 00:52:31,648 LED BY THE UNIVERSITY OF 1181 00:52:31,715 --> 00:52:33,783 COLORADO AND MENTIONED BY 1182 00:52:33,850 --> 00:52:36,152 DR. BIANCHI HAS SO FAR SUPPORTED 1183 00:52:36,219 --> 00:52:36,720 36 TRAINEES. 1184 00:52:36,786 --> 00:52:38,855 IF YOU DO THE MATH, THAT'S OVER 1185 00:52:38,922 --> 00:52:41,124 76 TRAINEES AND EARLY CAREER 1186 00:52:41,191 --> 00:52:42,392 INVESTIGATORS WHO BENEFITTED 1187 00:52:42,459 --> 00:52:44,528 FROM INCLUDE SUPPORT AND WE'RE 1188 00:52:44,594 --> 00:52:45,529 LOOKING TO SEE THAT NUMBER GROW 1189 00:52:45,595 --> 00:52:49,533 AND SEE SOME OF THOSE TRAINEES 1190 00:52:49,599 --> 00:52:51,001 SUCCESSFULLY COMPETE WITH NEW 1191 00:52:51,067 --> 00:52:51,468 AWARDS AS INDEPENDENT 1192 00:52:51,535 --> 00:52:55,505 INVESTIGATORS. 1193 00:52:55,572 --> 00:52:58,108 WE WANTED TO ALSO MENTION DS 1194 00:52:58,174 --> 00:52:59,910 CONNECT THE DOWN SYNDROME 1195 00:52:59,976 --> 00:53:00,176 REGISTRY. 1196 00:53:00,243 --> 00:53:04,147 A RESOURCE START NICHD IN 2013. 1197 00:53:04,214 --> 00:53:08,585 TO PROVIDE SECURE AND 1198 00:53:08,652 --> 00:53:10,420 CONFIDENTIAL SURVEY THAT WOULD 1199 00:53:10,487 --> 00:53:11,688 COLLECT INFORMATION FROM 1200 00:53:11,755 --> 00:53:12,989 INDIVIDUALS WITH DOWN SYNDROME 1201 00:53:13,056 --> 00:53:15,025 AND OFTEN TIMES FAMILY MEMBERS 1202 00:53:15,091 --> 00:53:16,526 WILL HELP WITH INPUTTING THE 1203 00:53:16,593 --> 00:53:16,826 DATA. 1204 00:53:16,893 --> 00:53:19,663 IT'S ALL WEB BASED AND ON THE 1205 00:53:19,729 --> 00:53:19,863 CLOUD. 1206 00:53:19,930 --> 00:53:23,099 I'M PLEASED TO ANNOUNCE WE'RE IN 1207 00:53:23,166 --> 00:53:25,936 THE PROCESS OF RELAUNCHING THE 1208 00:53:26,002 --> 00:53:28,071 WEBSITE AND NEW IMPROVED VERSION 1209 00:53:28,138 --> 00:53:29,472 OF THE REGISTRY ON A PLATFORM 1210 00:53:29,539 --> 00:53:30,607 HOSTED BY THE UNIVERSITY OF 1211 00:53:30,674 --> 00:53:31,942 COLORADO BUT CONTINUE TO BE 1212 00:53:32,008 --> 00:53:33,376 SUPPORTED BY THE NIH AND BY THE 1213 00:53:33,443 --> 00:53:41,985 INCLUDE PROJECT. 1214 00:53:42,052 --> 00:53:48,658 THERE'S SCIENTIFIC PROFESSIONAL 1215 00:53:48,725 --> 00:53:49,392 LISTED AS POTENTIAL 1216 00:53:49,459 --> 00:53:50,560 PROFESSIONALS FOR FAMILIES WHO 1217 00:53:50,627 --> 00:53:51,928 REGISTER AN ACCOUNT AND WANT TO 1218 00:53:51,995 --> 00:53:54,364 KNOW IF THEY MAY BE ABLE TO FIND 1219 00:53:54,431 --> 00:53:55,365 A PARTICULAR HEALTH CARE 1220 00:53:55,432 --> 00:54:00,503 PROVIDER AND FINALLY THE DS 1221 00:54:00,570 --> 00:54:04,174 CONNECT REGISTRY HAS HELPED WITH 1222 00:54:04,240 --> 00:54:05,575 RECRUITMENT FOR OVER 100 1223 00:54:05,642 --> 00:54:06,009 RESEARCH PROJECT. 1224 00:54:06,076 --> 00:54:08,612 THE GOAL IS TO CONNECT 1225 00:54:08,678 --> 00:54:10,413 INDIVIDUALS WITH RESEARCH 1226 00:54:10,480 --> 00:54:11,314 THEY'RE INTERESTED IN, THEY 1227 00:54:11,381 --> 00:54:13,550 CHOOSE WHETHER OR NOT THEY WANT 1228 00:54:13,617 --> 00:54:15,418 TO PARTICIPATE IN ALL IN A 1229 00:54:15,485 --> 00:54:16,553 CONFIDENTIAL MANNER. 1230 00:54:16,620 --> 00:54:17,520 WE'RE GOING TO CONTINUE THAT 1231 00:54:17,587 --> 00:54:27,931 UNDER ITS NEW HOME. 1232 00:54:28,298 --> 00:54:31,034 COMMUNITY OUTREACH AND THIS IS A 1233 00:54:31,101 --> 00:54:37,173 ROAD MAP OF 2024 INTO EARLY 1234 00:54:37,240 --> 00:54:37,440 2025. 1235 00:54:37,507 --> 00:54:39,743 WE HAVE A LOT OF MEETINGS WE 1236 00:54:39,809 --> 00:54:41,277 ATTEND OFTEN TIMES WITH RESEARCH 1237 00:54:41,344 --> 00:54:42,979 PROJECTS FROM INCLUDE AND THE 1238 00:54:43,046 --> 00:54:44,848 INCLUDE DCC. 1239 00:54:44,914 --> 00:54:47,117 WE HAVE BEEN ATTENDING A VARIETY 1240 00:54:47,183 --> 00:54:48,718 OF PROFESSIONAL ORGANIZATIONS, 1241 00:54:48,785 --> 00:54:49,986 INTERNATIONAL ORGANIZATIONS AND 1242 00:54:50,053 --> 00:54:54,257 WE WILL HAVE A STRONG PRESENCE 1243 00:54:54,324 --> 00:54:56,559 AT THE TRISOM RESEARCH SOCIETY 1244 00:54:56,626 --> 00:54:59,195 HELD IN ROME IN JUNE AND 1245 00:54:59,262 --> 00:55:00,330 HOPEFULLY WILL SEE SOME OF YOU 1246 00:55:00,397 --> 00:55:01,765 THERE AS WELL. 1247 00:55:01,831 --> 00:55:04,200 DIVERSITY, EQUITY, INCLUSION AND 1248 00:55:04,267 --> 00:55:05,635 ACCOUNTABILITY ARE ALSO A KEY 1249 00:55:05,702 --> 00:55:07,604 COMPONENT OF THE INCLUDE 1250 00:55:07,671 --> 00:55:08,038 INITIATIVE. 1251 00:55:08,104 --> 00:55:10,273 AND REALLY FORM A CORNERSTONE OF 1252 00:55:10,340 --> 00:55:12,308 WHAT WE'RE TRYING TO DO BOTH 1253 00:55:12,375 --> 00:55:14,577 WITH REGARD TO RESEARCH 1254 00:55:14,644 --> 00:55:16,413 PARTICIPANTS AND ALSO WITH 1255 00:55:16,479 --> 00:55:18,248 REGARD TO INVESTIGATORS. 1256 00:55:18,314 --> 00:55:19,949 WE'VE BEEN TRYING HARD TO 1257 00:55:20,016 --> 00:55:21,518 ESTABLISH POSITIVE RELATIONSHIPS 1258 00:55:21,584 --> 00:55:22,686 WITH THE COMMUNITY. 1259 00:55:22,752 --> 00:55:27,424 WE HAVE HOSTED A NUMBER OF DEIA 1260 00:55:27,490 --> 00:55:30,393 WEBINARS THAT HAVE INFORMATION 1261 00:55:30,460 --> 00:55:36,332 AND SPEARHWE HAVE PARTICIPATED 1262 00:55:36,399 --> 00:55:39,169 MEETINGS FOR EARLY STAGE 1263 00:55:39,235 --> 00:55:40,870 INVESTIGATORS PARTICULARLY THOSE 1264 00:55:40,937 --> 00:55:42,338 WHO MAY BE FROM UNDER 1265 00:55:42,405 --> 00:55:44,974 REPRESENTED COMMUNITIES SUCH AS 1266 00:55:45,041 --> 00:55:51,448 THE SOCIETY FOR THE ADVANCEMENT 1267 00:55:51,514 --> 00:55:57,454 OF CHICANOS AND THE BIOMEDICAL 1268 00:55:57,520 --> 00:56:00,623 RESEARCH CONFERENCE AND WE MET 1269 00:56:00,690 --> 00:56:01,958 WITH A GROUP IN PUERTO RICO AND 1270 00:56:02,025 --> 00:56:05,228 LINDA GARCIA WHO IS NOT ABLE TO 1271 00:56:05,295 --> 00:56:08,932 BE WITH US HERE TODAY 1272 00:56:08,998 --> 00:56:11,434 PARTICIPATED IN A CONGRESS IN 1273 00:56:11,501 --> 00:56:12,869 COSTA RICA AND WE'RE EXCITED 1274 00:56:12,936 --> 00:56:15,405 WITH OUR INTERNATIONAL 1275 00:56:15,472 --> 00:56:16,005 PARTNERSHIPS AND EFFORTS TO 1276 00:56:16,072 --> 00:56:17,540 INCREASE DIVERSITY WITHIN THE 1277 00:56:17,607 --> 00:56:18,975 INCLUDE INITIATIVE. 1278 00:56:19,042 --> 00:56:20,844 SPEAKING OF DEIA WEBINARS, I 1279 00:56:20,910 --> 00:56:21,711 WANT TO ENCOURAGE EVERYBODY TO 1280 00:56:21,778 --> 00:56:24,848 SIGN UP FOR THE NEXT UPCOMING 1281 00:56:24,914 --> 00:56:26,783 WEBINAR MAY 30, 2024. 1282 00:56:26,850 --> 00:56:31,488 THIS IS FREE, OPEN TO EVERYBODY. 1283 00:56:31,554 --> 00:56:39,028 IT'S ALL VIRTUAL THROUGH THE NIH 1284 00:56:39,095 --> 00:56:41,765 VIDEOCAST AND THOSE DOING 1285 00:56:41,831 --> 00:56:45,001 RESEARCH INVOLVING INDIVIDUALS 1286 00:56:45,068 --> 00:56:46,402 WITH DID DOWN SYNDROME MAY FIND 1287 00:56:46,469 --> 00:56:49,339 THIS SOMETHING. 1288 00:56:50,373 --> 00:56:53,810 P CORI HAS A GREAT DEAL OF 1289 00:56:53,877 --> 00:56:54,444 EXPERIENCE IN PATIENT-FOCUSSED 1290 00:56:54,511 --> 00:56:55,545 RESEARCH ARE. 1291 00:56:55,612 --> 00:56:57,814 I'M WINDING DOWN BUT I WANTED TO 1292 00:56:57,881 --> 00:56:58,815 INTRODUCE TO YOU A NEW 1293 00:56:58,882 --> 00:57:00,216 INITIATIVE THAT IS PART OF 1294 00:57:00,283 --> 00:57:03,219 INCLUDE THAT WE'RE VERY EXCITED 1295 00:57:03,286 --> 00:57:03,653 ABOUT. 1296 00:57:03,720 --> 00:57:05,388 THE DOWN SYNDROME INCLUDE COHORT 1297 00:57:05,455 --> 00:57:07,357 DEVELOPMENT PROGRAM ALSO KNOWN 1298 00:57:07,423 --> 00:57:08,491 AS DSCDP. 1299 00:57:08,558 --> 00:57:12,495 THIS IS GOING TO BE A 1300 00:57:12,562 --> 00:57:14,030 PROSPECTIVE STUDY THAT IS 1301 00:57:14,097 --> 00:57:16,900 INVOLVING AND GATHERING A LARGE 1302 00:57:16,966 --> 00:57:18,535 COHOST PEOPLE WITH DOWN SYNDROME 1303 00:57:18,601 --> 00:57:25,875 TO UNDER GO COMPREHENSIVE DEEP 1304 00:57:25,942 --> 00:57:27,977 PHENOTYPING UNDER A COMMON 1305 00:57:28,044 --> 00:57:28,411 PROTOCOL. 1306 00:57:28,478 --> 00:57:33,750 WE'RE WE ARE IN THE PROCESS OF 1307 00:57:33,817 --> 00:57:36,653 COMPETING THE AND THESE ARE THE 1308 00:57:36,719 --> 00:57:41,191 YELLOW CIRCLES ON THE LEFT AND 1309 00:57:41,257 --> 00:57:48,598 WE'LL BE SXEHARING AND COLLECTI 1310 00:57:48,665 --> 00:57:50,433 THE DEMOGRAPHIC AND CLINICAL 1311 00:57:50,500 --> 00:57:54,270 DATA AND ALLOWING FOR DISCOVERY 1312 00:57:54,337 --> 00:57:55,371 AND VALIDATION OF POTENTIALLY 1313 00:57:55,438 --> 00:57:57,006 NEW BIOLOGICAL TARGETS. 1314 00:57:57,073 --> 00:58:00,844 AND THEN FINALLY WE WILL HAVE A 1315 00:58:00,910 --> 00:58:05,081 BIO SPECIMEN ACQUISITION AND 1316 00:58:05,148 --> 00:58:07,417 SHARING INITIATIVE WHICH IS THE 1317 00:58:07,483 --> 00:58:09,485 SQUARE DOWN BELOW BE COMPETED 1318 00:58:09,552 --> 00:58:14,324 THIS SUMMER AND A FEDERATED 1319 00:58:14,390 --> 00:58:15,792 EFFORT TO BRING TOGETHER BIO 1320 00:58:15,859 --> 00:58:17,460 SPECIMEN BANKING EFFORTS FOR THE 1321 00:58:17,527 --> 00:58:19,062 AUSPICES OF ONE ENTITY TO HELP 1322 00:58:19,128 --> 00:58:20,730 COLLECT THE SAMPLES FROM THE 1323 00:58:20,797 --> 00:58:21,598 LARGE COHORT DEVELOPMENT 1324 00:58:21,664 --> 00:58:21,865 PROGRAM. 1325 00:58:21,931 --> 00:58:24,133 AND ALL THESE PIECES WILL BE 1326 00:58:24,200 --> 00:58:25,835 INTEGRATED WITH THE INCLUDE DCC 1327 00:58:25,902 --> 00:58:27,871 SO THE DATA WILL BE HARMONIZED 1328 00:58:27,937 --> 00:58:28,471 AND AVAILABLE FOR BROAD DATA 1329 00:58:28,538 --> 00:58:29,706 SHARING. 1330 00:58:29,772 --> 00:58:31,441 SO STAY TUNED FOR MORE ABOUT 1331 00:58:31,507 --> 00:58:33,243 THIS AND WE'RE VERY EXCITED 1332 00:58:33,309 --> 00:58:33,509 ABOUT IT. 1333 00:58:33,576 --> 00:58:36,679 SO I JUST WANT TO CLOSE BY 1334 00:58:36,746 --> 00:58:38,081 THANKING OUR INCLUDE 1335 00:58:38,147 --> 00:58:38,748 INVESTIGATORS MEETING PLANNING 1336 00:58:38,815 --> 00:58:40,750 TEAM SOME OF WHOM ARE SITTING 1337 00:58:40,817 --> 00:58:42,418 DOWN HERE, SOME OF WHOM ARE 1338 00:58:42,485 --> 00:58:43,920 SCATTERED ELSEWHERE. 1339 00:58:43,987 --> 00:58:44,787 WE COULDN'T HAVE DONE THIS 1340 00:58:44,854 --> 00:58:47,757 WITHOUT YOU AND GRATEFUL FOR OUR 1341 00:58:47,824 --> 00:58:49,659 PARTNERS AND SPECIAL THANKS TO 1342 00:58:49,726 --> 00:58:57,166 ISAIAH AKBAR AND KEYLA FOR 1343 00:58:57,233 --> 00:58:59,435 SUPPORTING OUR EFFORTS. 1344 00:58:59,502 --> 00:59:00,103 THANK YOU DMOR JOINING US ON THE 1345 00:59:00,169 --> 00:59:01,437 LOVELY NIH CAMPUS AND PLEASE 1346 00:59:01,504 --> 00:59:03,973 ENGAGE IN ALL OF THE ACTIVITIES 1347 00:59:04,040 --> 00:59:06,276 YOU CAN AND WE HOPE YOU ENJOY 1348 00:59:06,342 --> 00:59:06,776 THE REST OF THE MEETING. 1349 00:59:06,843 --> 00:59:17,020 THANK YOU. 1350 00:59:32,669 --> 00:59:36,139 >> I'M CHARLENE TRAM I'M A 1351 00:59:36,205 --> 00:59:38,374 PROGRAM DIRECTOR AT THE 1352 00:59:38,441 --> 00:59:44,480 NATIONAL, HEART, LUNG, BLOOD. 1353 00:59:44,547 --> 00:59:47,917 SO USED TO ACRONYMS I FORGET THE 1354 00:59:47,984 --> 00:59:49,619 FULL NAME. 1355 00:59:49,686 --> 00:59:54,157 I'M A MEMBER OF THE INCLUDE DOWN 1356 00:59:54,223 --> 00:59:55,425 SYNDROME WORKING GROUP AND I AM 1357 00:59:55,491 --> 00:59:58,461 HERE TODAY BECAUSE I HAVE THE 1358 00:59:58,528 --> 00:59:59,862 PRIVILEGE OF BEING THE LEAD 1359 00:59:59,929 --> 01:00:04,267 MEMBER OF OUR WORKING GROUP FOR 1360 01:00:04,334 --> 01:00:06,402 THE BASIC SCIENCE COMPONENT OF 1361 01:00:06,469 --> 01:00:13,643 THE INCLUDE PROJECT. 1362 01:00:13,710 --> 01:00:15,678 NAEFRT PRIF 1363 01:00:17,613 --> 01:00:20,616 PART OF THE PRIVILEGES ARE TO 1364 01:00:20,683 --> 01:00:23,653 INTRODUCE THE SPEAKER FOR THE 1365 01:00:23,720 --> 01:00:25,555 NEXT WE'LL HEAR THREE TALKS AND 1366 01:00:25,621 --> 01:00:27,890 GET IN THE SCIENCE RIGHT NOW. 1367 01:00:27,957 --> 01:00:31,127 WE'LL HAVE THREE TALKS AND THEN 1368 01:00:31,194 --> 01:00:34,030 I'LL ASK THE THREE SPEAKERS TO 1369 01:00:34,097 --> 01:00:38,401 COME TO THE FRONT AND WE WILL 1370 01:00:38,468 --> 01:00:43,806 HAVE 15 MINUTES AVAILABLE FOR 1371 01:00:43,873 --> 01:00:44,507 QUESTIONS AND DISCUSSION. 1372 01:00:44,574 --> 01:00:45,942 AFTER THAT WE'LL HAVE A SHORT 1373 01:00:46,009 --> 01:00:52,982 BREAK AND THEN WE WILL CONTINUE 1374 01:00:53,049 --> 01:00:57,220 THE DISCUSSION OF PARTICULARLY 1375 01:00:57,286 --> 01:01:00,056 OF AVAILABLE MODEL SYSTEMS FOR 1376 01:01:00,123 --> 01:01:04,527 BASIC SCIENCE AND OTHER 1377 01:01:04,594 --> 01:01:13,369 SCIENTIFIC ASPECTS. 1378 01:01:13,436 --> 01:01:14,103 WE'LL HAVE ANOTHER PANEL I'LL 1379 01:01:14,170 --> 01:01:15,938 TELL YOU ABOUT AFTER THE BREAK 1380 01:01:16,005 --> 01:01:16,906 AND START WITH SCIENTIFIC TALKS 1381 01:01:16,973 --> 01:01:20,176 AND THEN GET A CHANCE TO TALK A 1382 01:01:20,243 --> 01:01:21,544 LITTLE BIT MORE ABOUT THE 1383 01:01:21,611 --> 01:01:24,013 SPECIFIC CHALLENGES THAT COME 1384 01:01:24,080 --> 01:01:27,550 WITH BASIC SCIENCE AND STUDYING 1385 01:01:27,617 --> 01:01:28,451 DOWN SYNDROME. 1386 01:01:28,518 --> 01:01:38,394 OUR FIRST SPEAKER IS MICHAEL 1387 01:01:38,461 --> 01:01:42,231 YEAGER. 1388 01:01:42,298 --> 01:01:45,802 THE THEME OF THE FIRST SESSION 1389 01:01:45,868 --> 01:01:54,410 IS USE OF A VARIETY OF 1390 01:01:54,477 --> 01:02:04,821 EXPERIMENTAL MODELS. 1391 01:02:10,693 --> 01:02:13,296 WE'LL INDICATE HOW MUCH TIME IS 1392 01:02:13,362 --> 01:02:13,496 LEFT. 1393 01:02:13,563 --> 01:02:14,964 WE HAVE LIGHTS BUT CAN'T MAKE 1394 01:02:15,031 --> 01:02:15,264 THEM WORK. 1395 01:02:15,331 --> 01:02:16,265 >> THANK YOU FOR THE 1396 01:02:16,332 --> 01:02:17,266 INTRODUCTION AND I THINK WE'RE 1397 01:02:17,333 --> 01:02:19,669 OFF TO A GREAT START. 1398 01:02:19,735 --> 01:02:26,909 I JUST WANT TO SAY THANKS TO THE 1399 01:02:26,976 --> 01:02:27,643 ORGANIZA 1400 01:02:27,710 --> 01:02:28,377 ORGANIZERS AND THE CHANCE TO 1401 01:02:28,444 --> 01:02:29,645 TALK ABOUT WHAT OUR LAB IS 1402 01:02:29,712 --> 01:02:29,846 DOING. 1403 01:02:29,912 --> 01:02:32,548 FOR SEVERAL YEARS NOW AND IT'S A 1404 01:02:32,615 --> 01:02:34,350 LITTLE BIT DIFFERENT THAN THE 1405 01:02:34,417 --> 01:02:36,452 THRUSTS OF WHAT YOU MIGHT HEAR 1406 01:02:36,519 --> 01:02:37,620 THROUGHOUT THE MORNING IN TERMS 1407 01:02:37,687 --> 01:02:39,722 OF DATA SCIENCE WE'RE MORE 1408 01:02:39,789 --> 01:02:40,156 PATHOPHYSIOLOGISTS. 1409 01:02:40,223 --> 01:02:42,425 I WANT TO MAKE A PLUG FOR THAT 1410 01:02:42,492 --> 01:02:44,660 TOO AS WE GO. 1411 01:02:44,727 --> 01:02:46,829 WITHOUT FURTHER ADO, I HAVE NO 1412 01:02:46,896 --> 01:02:47,964 CONFLICTS OF INTEREST TO DECLARE 1413 01:02:48,030 --> 01:02:50,133 AND I ALWAYS LIKE TO HAVE A FEW 1414 01:02:50,199 --> 01:02:51,000 LEARNING OBJECTIVES. 1415 01:02:51,067 --> 01:02:54,370 I WON'T READ TO YOU, I PROMISE. 1416 01:02:54,437 --> 01:02:55,538 HOPEFULLY AFTER THIS 10, 15 1417 01:02:55,605 --> 01:02:59,475 MINUTES YOU'LL HEAR MORE THAN 1418 01:02:59,542 --> 01:03:01,377 YOU KNEW BEFORE ABOUT CARDIO 1419 01:03:01,444 --> 01:03:02,044 PULMONARY DISEASE. 1420 01:03:02,111 --> 01:03:07,583 MY BACKGROUND AND TRAINING IS IN 1421 01:03:07,650 --> 01:03:09,018 PULMONARY HYPERTENSION AND WANT 1422 01:03:09,085 --> 01:03:10,720 YOU TO BE MORE FAMILIAR WITH THE 1423 01:03:10,786 --> 01:03:13,990 BIOLOGICAL MECHANISMS WE THINK 1424 01:03:14,056 --> 01:03:17,160 ARE INVOLVED IN INCREASING 1425 01:03:17,226 --> 01:03:19,695 SUSCEPTIBILITY FOR PERSONS TO 1426 01:03:19,762 --> 01:03:21,531 RESPIRATORY INFECTION AND THEN 1427 01:03:21,597 --> 01:03:22,532 GO INTO NEW AVENUES TO WHAT 1428 01:03:22,598 --> 01:03:23,933 WE'VE BEEN DOING. 1429 01:03:24,000 --> 01:03:29,238 AS WE HEARD THE GOAL IS TO 1430 01:03:29,305 --> 01:03:31,040 IMPROVE THE QUALITY OF LIFE AND 1431 01:03:31,107 --> 01:03:33,176 AGREE WITH OUR ESTEEMED FIRST 1432 01:03:33,242 --> 01:03:33,409 SPEAKER. 1433 01:03:33,476 --> 01:03:34,877 THERE'S MANY DATA SETS. 1434 01:03:34,944 --> 01:03:35,745 WE ONLY HAVE 15 MINUTES SO I 1435 01:03:35,811 --> 01:03:37,013 PICKED A FEW. 1436 01:03:37,079 --> 01:03:39,916 THIS IS FROM YANG ET AL. ABOUT 1437 01:03:39,982 --> 01:03:41,851 20 YEARS AGO BUT FOLLOWED UP IN 1438 01:03:41,918 --> 01:03:42,285 SEVERAL STUDIES. 1439 01:03:42,351 --> 01:03:45,054 I PUT AN ARROW IN CASE LASERS 1440 01:03:45,121 --> 01:03:47,690 DON'T WORK BUT IF YOU THINK 1441 01:03:47,757 --> 01:03:48,824 ABOUT HIGH LUNG MORBIDITY AND 1442 01:03:48,891 --> 01:03:50,159 MORTALITY, WHAT ARE THE NUMBERS 1443 01:03:50,226 --> 01:03:54,497 THAT BACK THIS UP? 1444 01:03:54,564 --> 01:03:55,665 AS A PLUG, THIS IS SOMETHING 1445 01:03:55,731 --> 01:03:58,234 WE'VE BEEN WORKING ON ABOUT FIVE 1446 01:03:58,301 --> 01:03:59,502 YEARS. 1447 01:03:59,569 --> 01:04:00,469 NO OFFENSE TO THE EARLIER 1448 01:04:00,536 --> 01:04:02,338 SPEAKERS BUT ALWAYS IN THE LIST 1449 01:04:02,405 --> 01:04:03,639 OF THINGS THAT ARE PROBLEMS FOR 1450 01:04:03,706 --> 01:04:07,510 PEOPLE WITH DOWN SYNDROME IT'S 1451 01:04:07,577 --> 01:04:09,045 ALWAYS ALZHEIMER'S, LEUKEMIA AND 1452 01:04:09,111 --> 01:04:11,013 THEY'RE PROTECT FROM OTHER 1453 01:04:11,080 --> 01:04:11,247 THINGS. 1454 01:04:11,314 --> 01:04:13,716 IN THE NEXT SLIDES I'LL TRY TO 1455 01:04:13,783 --> 01:04:15,851 CONVINCE THE MAJOR PROBLEM FOR A 1456 01:04:15,918 --> 01:04:18,421 MAJOR PROBLEM IS RESPIRATORY 1457 01:04:18,487 --> 01:04:18,988 TRACT INFECTION. 1458 01:04:19,055 --> 01:04:21,624 AND I PUT A PLUG FOR CONGENITAL 1459 01:04:21,691 --> 01:04:25,795 HEART DEFECTS BUT YOU LOOK AT 1460 01:04:25,861 --> 01:04:28,097 THIS AND IT'S A DIFFERENT WAY TO 1461 01:04:28,164 --> 01:04:29,065 REPRESENTATIVE THE DATA. 1462 01:04:29,131 --> 01:04:32,468 IF YOU LOOK AT ASPIRATION OR 1463 01:04:32,535 --> 01:04:33,936 INFLUENZA AND PNEUMONIA AND GO 1464 01:04:34,003 --> 01:04:39,642 ACROSS THE LIFE SPAN AND I'VE 1465 01:04:39,709 --> 01:04:43,279 HIGHLIGHTED THIS FOR YOU, AT THE 1466 01:04:43,346 --> 01:04:44,013 DECADES IN WHICH YOU'D EXPECT 1467 01:04:44,080 --> 01:04:47,683 HIGH LEVELS OF DEMENTIA, THE 1468 01:04:47,750 --> 01:04:50,419 DOMINANT COMORBIDITY HERE IS 1469 01:04:50,486 --> 01:04:50,953 RESPIRATORY TRACT INFECT. 1470 01:04:51,020 --> 01:04:53,089 -- INFECTION. 1471 01:04:53,155 --> 01:04:55,391 I WOULD BE REMISS IF I WERE HERE 1472 01:04:55,458 --> 01:05:00,263 AND WE DIDN'T TALK A LITTLE BIT 1473 01:05:00,329 --> 01:05:02,365 ABOUT SARS, COV2, COVID-19 AND 1474 01:05:02,431 --> 01:05:05,635 ALL REPRESENTATIONS OF THE SAME 1475 01:05:05,701 --> 01:05:06,035 IDEA. 1476 01:05:06,102 --> 01:05:07,336 THIS FROM THE COVID-19 1477 01:05:07,403 --> 01:05:07,937 INITIATIVE PUBLISHED BACK IN 1478 01:05:08,004 --> 01:05:08,904 2021. 1479 01:05:08,971 --> 01:05:13,609 AND WHAT YOU CAN SEE IS IN 1480 01:05:13,676 --> 01:05:15,611 PURPLE INDIVIDUALS WITH DOWN 1481 01:05:15,678 --> 01:05:17,413 SYNDROME ARE MORE SUSCEPTIBLE TO 1482 01:05:17,480 --> 01:05:18,681 DEATH FROM SARS COV2. 1483 01:05:18,748 --> 01:05:20,783 I PUT SOME LISTS ON HERE ABOUT 1484 01:05:20,850 --> 01:05:22,985 SOME OTHER THINGS MIGHT THINK 1485 01:05:23,052 --> 01:05:23,185 ABOUT. 1486 01:05:23,252 --> 01:05:25,855 WHAT I'D LIKE TO SAY ABOUT THIS 1487 01:05:25,921 --> 01:05:28,391 THOUGH AS A LUNG RESEARCHER FOR 1488 01:05:28,457 --> 01:05:30,059 A LONG TIME THE COVID BLOCK OF 1489 01:05:30,126 --> 01:05:32,795 DATA FROM 2020 TO NOW IS VERY 1490 01:05:32,862 --> 01:05:35,765 MURKY. 1491 01:05:35,831 --> 01:05:37,733 AND AS THE PEOPLE WHO JUMPED IN 1492 01:05:37,800 --> 01:05:39,468 THE SPACE AND DID QUICK STUDIES 1493 01:05:39,535 --> 01:05:42,405 AND THE DATA IS DIFFICULT TO 1494 01:05:42,471 --> 01:05:43,706 WORK THROUGH. 1495 01:05:43,773 --> 01:05:45,608 FOR EXAMPLE, WHO DIED IN 1496 01:05:45,675 --> 01:05:49,845 COVID-19 VERSUS WHO DIED WITH 1497 01:05:49,912 --> 01:05:51,647 COVID-19 AND THIS IS A BIG 1498 01:05:51,714 --> 01:05:53,282 PROBLEM FOR US IN THE LUNG 1499 01:05:53,349 --> 01:05:55,251 COMMUNITY RIGHT NOW. 1500 01:05:55,318 --> 01:05:57,353 FOR EXAMPLE, IT'S UNKNOWN 1501 01:05:57,420 --> 01:05:59,989 SPECIFIC FACTORS, OBESITY AND 1502 01:06:00,056 --> 01:06:03,626 OTHERS WERE AS CONTRIBUTORY OR 1503 01:06:03,693 --> 01:06:07,363 MORE CONTRIBUTORY THAN THE 1504 01:06:07,430 --> 01:06:09,065 CONDITION OF HAVING DOWN 1505 01:06:09,131 --> 01:06:09,332 SYNDROME. 1506 01:06:09,398 --> 01:06:12,635 I WAS INVITED TO TALK ABOUT THE 1507 01:06:12,702 --> 01:06:14,570 NEWER STUFF WE'VE BEEN DOING IN 1508 01:06:14,637 --> 01:06:17,440 THE MOUSE AND RAT MODELS. 1509 01:06:17,506 --> 01:06:21,677 WE MADE AN ARNO 20 AND WE'LL 1510 01:06:21,744 --> 01:06:26,382 PUBLISH OUR FIRST DATA IN ARNO 1511 01:06:26,449 --> 01:06:34,790 20 IN A MONTH AND THESE ARE 1512 01:06:34,857 --> 01:06:39,895 SEQUENTIAL DUPLICATION AND WHERE 1513 01:06:39,962 --> 01:06:44,166 SEGMENTS OF HSA21 ARE 1514 01:06:44,233 --> 01:06:45,167 DUPLICATED. 1515 01:06:45,234 --> 01:06:46,836 THERE'S IMPORTANT 1516 01:06:46,902 --> 01:06:47,203 CONSIDERATIONS. 1517 01:06:47,269 --> 01:06:48,170 THERE'S OTHER DIFFERENCES BUT 1518 01:06:48,237 --> 01:06:50,172 YOU GET OVERSUPPRESSION OF THE 1519 01:06:50,239 --> 01:06:52,475 GENES ON 16, 17 OR 10 DEPENDING 1520 01:06:52,541 --> 01:06:53,576 ON WHICH MOUSE YOU DO. 1521 01:06:53,642 --> 01:06:57,713 WE TOOK THE SAME APPROACH TO 1522 01:06:57,780 --> 01:07:02,218 MAKE ARNO 11 AND 20 AND WERE 1523 01:07:02,284 --> 01:07:02,518 SUCCESSFUL. 1524 01:07:02,585 --> 01:07:04,387 I WON'T TALK ABOUT THESE TODAY 1525 01:07:04,453 --> 01:07:06,922 BUT I'LL BE AROUND AND SHOW WHAT 1526 01:07:06,989 --> 01:07:08,224 YOU WE HAVE AVAILABLE FOR YOU 1527 01:07:08,290 --> 01:07:10,326 AND HAVE THE LIST OF GENES. 1528 01:07:10,393 --> 01:07:13,062 INVOLVED IN THIS CASE, RATS ARE 1529 01:07:13,129 --> 01:07:13,329 SIMPLER. 1530 01:07:13,396 --> 01:07:16,899 IT'S SPREAD ON TWO CHROMOSOMES 1531 01:07:16,966 --> 01:07:18,200 NOT THREE AND LESS INDIVIDUAL 1532 01:07:18,267 --> 01:07:19,735 RAT GENES DUPLICATED NOT PRESENT 1533 01:07:19,802 --> 01:07:20,736 IN HUMAN. 1534 01:07:20,803 --> 01:07:23,506 THERE'S LESS OF THAT. 1535 01:07:23,572 --> 01:07:25,107 SO WE THINK THAT IN CONJUNCTION 1536 01:07:25,174 --> 01:07:27,042 WITH THE IDEA THAT RATS ARE 1537 01:07:27,109 --> 01:07:30,146 GENERALLY BETTER AT BEHAVIORAL 1538 01:07:30,212 --> 01:07:33,416 STUDIES AND THEIR STRUCTURE 1539 01:07:33,482 --> 01:07:33,682 LARGER. 1540 01:07:33,749 --> 01:07:37,653 FOR US TO LOOK AT HEART AND LUNG 1541 01:07:37,720 --> 01:07:38,254 ARE EASIER. 1542 01:07:38,320 --> 01:07:40,356 THIS SIDE IS BODY WEIGHT AND ALL 1543 01:07:40,423 --> 01:07:42,925 THIS ON THE DP16 MICE BUT WANT 1544 01:07:42,992 --> 01:07:45,060 TO FOCUS YOUR ATTENTION HERE. 1545 01:07:45,127 --> 01:07:47,496 THIS AT 11 WEEKS A COHORT OF 1546 01:07:47,563 --> 01:07:50,433 MICE WE LOOKED AT IN TERMS OF 1547 01:07:50,499 --> 01:07:53,035 HOW WE ANESTHETIZE THEM TO DO 1548 01:07:53,102 --> 01:07:54,870 THE THINGS WE DO. 1549 01:07:54,937 --> 01:07:57,440 IT TURNS OUT THERE'S BROAD 1550 01:07:57,506 --> 01:08:01,243 VARIABILITY IN THE DP16 MOUSE TO 1551 01:08:01,310 --> 01:08:02,845 GET THEM TO COME DOWN TO WORK 1552 01:08:02,912 --> 01:08:05,414 WITH THEM AND I KNOW SOME HERE 1553 01:08:05,481 --> 01:08:07,983 ARE INTERESTED IN RESPONSE TO 1554 01:08:08,050 --> 01:08:09,718 ANESTHESIA AND IF YOU GET THEM 1555 01:08:09,785 --> 01:08:11,520 UNDER AND DO DIFFERENT THINGS, 1556 01:08:11,587 --> 01:08:13,222 ONE THING WE LOOKED AT WAS 1557 01:08:13,289 --> 01:08:14,490 MOLECULAR ANALYSIS. 1558 01:08:14,557 --> 01:08:17,460 WHAT WE FIND IS BROAD 1559 01:08:17,526 --> 01:08:21,063 VARIABILITY IN INTERFERON 1560 01:08:21,130 --> 01:08:21,530 RECEPTOR EXPRESSION. 1561 01:08:21,597 --> 01:08:22,731 THIS IS ACROSS THE BOARD. 1562 01:08:22,798 --> 01:08:25,034 WE LOOKED AT THIS IN MANY WAYS. 1563 01:08:25,100 --> 01:08:26,435 WE USED FIVE DIFFERENT 1564 01:08:26,502 --> 01:08:28,137 ANTIBODIES AND ASKED OTHER 1565 01:08:28,204 --> 01:08:32,274 PEOPLE FOR THEIR PROTEINS. 1566 01:08:32,341 --> 01:08:35,845 WE PUT THEM ON TE GELS AND THIS 1567 01:08:35,911 --> 01:08:36,679 IS CONSISTENT. 1568 01:08:36,745 --> 01:08:39,248 THE CONSISTENT, INCONSISTENTLY 1569 01:08:39,315 --> 01:08:40,649 PARALLELS WHAT WE HEARD FROM 1570 01:08:40,716 --> 01:08:44,220 ISAIAH THIS MORNING, THESE ARE 1571 01:08:44,286 --> 01:08:45,488 INDIVIDUALISTIC DP16 MICE IN 1572 01:08:45,554 --> 01:08:46,922 TERMS OF THE EXPRESSION. 1573 01:08:46,989 --> 01:08:48,190 THE EXPRESSION IS QUITE 1574 01:08:48,257 --> 01:08:48,457 VARIABLE. 1575 01:08:48,524 --> 01:08:52,495 WE DON'T SEE AT THE PROTEIN 1576 01:08:52,561 --> 01:08:56,432 LEVEL OVEREXPRESSERS AND DIDN'T 1577 01:08:56,499 --> 01:08:59,034 SEE DIFFERENCE IN PATH RECEPTOR 1578 01:08:59,101 --> 01:09:01,003 WHICH FACILITATED BACTERIAL 1579 01:09:01,070 --> 01:09:01,637 ADHESION AND YOU CAN SEE WHERE 1580 01:09:01,704 --> 01:09:03,572 I'M GOING WITH THAT. 1581 01:09:03,639 --> 01:09:05,975 SO TO CONCLUDE ON THIS SLIDE, AT 1582 01:09:06,041 --> 01:09:08,811 LEAST A PROTEIN LEVEL INTERFERON 1583 01:09:08,878 --> 01:09:10,012 DOESN'T SEEM TO BE PRESENT IN 1584 01:09:10,079 --> 01:09:10,746 THE MOUSE LUNG. 1585 01:09:10,813 --> 01:09:18,420 NOT TO SAY THERE'S NOT AN FE 1586 01:09:18,487 --> 01:09:21,190 FEARONOPFEARON 1587 01:09:21,257 --> 01:09:23,926 -- INTERFERONOPATHY AND THE 1588 01:09:23,993 --> 01:09:25,861 LUNG APPEARS TO ABBE 1589 01:09:25,928 --> 01:09:27,696 ACCOMMODATING THIS IN SOME WAY 1590 01:09:27,763 --> 01:09:30,299 AND WE HAVE QUANTITATIVE DATA 1591 01:09:30,366 --> 01:09:32,434 AND SOMETHING LIKE USP18 IF 1592 01:09:32,501 --> 01:09:34,136 YOU'RE INTERESTED IN INTERFERONS 1593 01:09:34,203 --> 01:09:35,437 GENERALLY COMES UP AS A RESPONSE 1594 01:09:35,504 --> 01:09:38,674 TO INTERFERON ENGAGEMENT AND 1595 01:09:38,741 --> 01:09:41,243 TENDS TO ATTENUATE THE SIGNAL. 1596 01:09:41,310 --> 01:09:42,845 WE DEFINITELY SEE THAT AND IT'S 1597 01:09:42,912 --> 01:09:44,513 BEEN SHOWN IN MANY PUBLICATIONS 1598 01:09:44,580 --> 01:09:47,516 GOING BACK 20 YEARS IN WHICH 1599 01:09:47,583 --> 01:09:50,052 THERE'S A SHORT TERM, MEDIUM YUM 1600 01:09:50,119 --> 01:09:52,788 AND LONG-TERM ACCOMMODATION THE 1601 01:09:52,855 --> 01:09:55,190 SYSTEM SEEMS TO ESTABLISH. 1602 01:09:55,257 --> 01:09:56,492 WHAT WE'RE PROPOSING WITH THE 1603 01:09:56,559 --> 01:10:01,130 MODEL IS THERE'S AN 1604 01:10:01,196 --> 01:10:03,299 INTERFEROPATHY AND PROBABLY ONE 1605 01:10:03,365 --> 01:10:06,135 AT THE EARLY LEVEL BUT IT 1606 01:10:06,201 --> 01:10:07,336 ATTEMPTS TO TURN THIS DOWN AT 1607 01:10:07,403 --> 01:10:13,409 THE PROTEIN LEVEL. 1608 01:10:13,475 --> 01:10:17,346 AGAIN, WE LIKE OMICS BUT WE'RE 1609 01:10:17,413 --> 01:10:18,080 PATHOPHYSIOLOGISTS AT HEART. 1610 01:10:18,147 --> 01:10:20,649 THIS IS JUST TO SHOW YOU BY 1611 01:10:20,716 --> 01:10:24,620 DIFFERENT MEASURES CONDUCTED AT 1612 01:10:24,687 --> 01:10:26,889 DIFFERENT PRESSURES THAT THE 1613 01:10:26,956 --> 01:10:28,891 ELASTIN OF THE LUNGS, HOW STIFF 1614 01:10:28,958 --> 01:10:31,160 IT, ALSO OF THE AIRWAYS, HOW ARE 1615 01:10:31,226 --> 01:10:35,130 THEY WORKING TO BRING IN AIR AND 1616 01:10:35,197 --> 01:10:39,268 SOMETHING CALLED INSPIRATORY 1617 01:10:39,335 --> 01:10:45,541 CAPACITY YOU CAN BREATH NORMAL 1618 01:10:45,608 --> 01:10:47,810 AND THE TIDAL VOLUME AND THE 1619 01:10:47,876 --> 01:10:50,913 RESERVE YOU CAN DRAW IN IS 1620 01:10:50,980 --> 01:10:51,380 RESPIRATORY CAPACITY. 1621 01:10:51,447 --> 01:10:54,350 WE SAW DIFFERENCES IN GENERALLY 1622 01:10:54,416 --> 01:10:57,686 THE LUNG IS NOT VENTILATING 1623 01:10:57,753 --> 01:10:58,754 PROPERLY. 1624 01:10:58,821 --> 01:11:02,157 IN ADDITION, AND WE FOUND IN 1625 01:11:02,224 --> 01:11:04,994 MICE THE INCREASED SIZE OF WHAT 1626 01:11:05,060 --> 01:11:06,295 WE CALL THE MEAN LANEIAR 1627 01:11:06,362 --> 01:11:09,431 INTERCEMENT WHERE WE LOOK AT 1628 01:11:09,498 --> 01:11:15,371 ALVEOLI AND THIS IS EQUIVALENT 1629 01:11:15,437 --> 01:11:22,478 TO AN EMPHYSEMA AND FINALLY MORE 1630 01:11:22,544 --> 01:11:28,450 TOWARDS THIS AREA WE FIND 1631 01:11:28,517 --> 01:11:35,724 PROMINENT LYMPHOID TISSUES THAT 1632 01:11:35,791 --> 01:11:39,395 CONTROL LOCAL LUNG IMMUNITY. 1633 01:11:39,461 --> 01:11:41,830 TO SUMMARIZE, THERE'S CLINICALLY 1634 01:11:41,897 --> 01:11:42,665 MEANINGFUL LUNG CAPACITY IN MICE 1635 01:11:42,731 --> 01:11:45,701 THAT MAY BE LINKED TO INCREASES 1636 01:11:45,768 --> 01:11:46,902 IN THE STRUCTURAL DIFFERENCES 1637 01:11:46,969 --> 01:11:50,272 AND SOME OF THOSE STRUCTURAL 1638 01:11:50,339 --> 01:11:52,074 DIFFERENCE IMMUNOLOGICAL GUIDES 1639 01:11:52,141 --> 01:11:54,410 THE LUNG USES WE THINK ARE 1640 01:11:54,476 --> 01:11:55,911 PROBABLY DIFFERENT IN PEOPLE 1641 01:11:55,978 --> 01:11:57,212 WITH DOWN SYNDROME. 1642 01:11:57,279 --> 01:11:58,914 IF WE GO TO HEARTS REAL QUICK I 1643 01:11:58,981 --> 01:12:01,016 HAVE THREE MINUTES. 1644 01:12:01,083 --> 01:12:03,419 THESE ARE MEASURES HOW THE RIGHT 1645 01:12:03,485 --> 01:12:06,588 VENTRICLE IS DOING WHEN WE HAVE 1646 01:12:06,655 --> 01:12:08,724 SEPTAL DEFECTS BETWEEN THE RIGHT 1647 01:12:08,791 --> 01:12:12,127 AND LEFT VENTRICLE AND LOOK AT 1648 01:12:12,194 --> 01:12:18,434 CARDIO GRAPHY AND INVASIVE CATH 1649 01:12:18,500 --> 01:12:19,601 AND LOOK IF THERE'S 1650 01:12:19,668 --> 01:12:21,236 COMMUNICATION AND LOOK AT IF 1651 01:12:21,303 --> 01:12:24,073 THERE'S INCREASED FLUID ON THE 1652 01:12:24,139 --> 01:12:25,074 RIGHT VENTRICLE OR GROWS IN SIZE 1653 01:12:25,140 --> 01:12:27,076 AS YOU EXPECT A MUSCLE HAVING TO 1654 01:12:27,142 --> 01:12:28,510 WORK HARDER DOES. 1655 01:12:28,577 --> 01:12:30,479 DON'T SEE ANY REAL CHANGE 1656 01:12:30,546 --> 01:12:30,813 THERE'S. 1657 01:12:30,879 --> 01:12:32,748 ALSO DIDN'T SEE OVER EXPRESSION 1658 01:12:32,815 --> 01:12:34,516 OF INTERFERON RECEPTORS. 1659 01:12:34,583 --> 01:12:38,420 BUT IMPORTANTLY, WHEN WE GET TO 1660 01:12:38,487 --> 01:12:40,055 THE PATHOPHYSIOLOGY THIS NUMBER 1661 01:12:40,122 --> 01:12:42,458 THE MEAN PRESSURE IS IMPORTANT. 1662 01:12:42,524 --> 01:12:44,159 IT'S NORMALLY ABOUT 15 AND IT IS 1663 01:12:44,226 --> 01:12:47,963 15 IN CONTROLS IN DP16 AND THIS 1664 01:12:48,030 --> 01:12:50,399 SUGGESTS IN DP16 MICE AND THIS 1665 01:12:50,466 --> 01:12:52,234 IS 10 FEMALES AND 10 MALES AND 1666 01:12:52,301 --> 01:12:57,740 WE HAVE THE SAME DATA FOR ECHO 1667 01:12:57,806 --> 01:13:03,746 CA 1668 01:13:03,812 --> 01:13:05,614 CAR 1669 01:13:05,681 --> 01:13:06,415 CARDIOGRAPHY AND IN WERE 1670 01:13:06,482 --> 01:13:08,450 DIFFERENCES IT WOULD BE HIGHER. 1671 01:13:08,517 --> 01:13:09,885 THAT'S SUMMARIZED HERE. 1672 01:13:09,952 --> 01:13:12,721 WE HAVE TO GET TO THE ANSWER 1673 01:13:12,788 --> 01:13:16,158 HERE BECAUSE CHD AND 16 MICE THE 1674 01:13:16,225 --> 01:13:18,994 INITIAL REPORTS WERE 33 TO 22% 1675 01:13:19,061 --> 01:13:21,396 AND THERE'S BEEN REPORTS WHERE 1676 01:13:21,463 --> 01:13:23,098 TWO-THIRDS OF ANIMALS ARE HAVING 1677 01:13:23,165 --> 01:13:25,667 THIS AND OUR DATA DOESN'T SHOW 1678 01:13:25,734 --> 01:13:28,771 CLINICAL OR MEANINGFUL BY ECHO 1679 01:13:28,837 --> 01:13:29,671 AND CATH AND NOT MUCH OVER 1680 01:13:29,738 --> 01:13:33,642 EXPRESSION AT THE PROTEIN LEVEL. 1681 01:13:33,709 --> 01:13:35,477 THIS IS WHAT PNEUMONIA LOOKS 1682 01:13:35,544 --> 01:13:36,745 LIKE IN DP16. 1683 01:13:36,812 --> 01:13:37,079 IT'S HORRIBLE. 1684 01:13:37,146 --> 01:13:38,480 AND WHAT IT LOOKS LIKE IN 1685 01:13:38,547 --> 01:13:38,747 CONTROLS. 1686 01:13:38,814 --> 01:13:39,314 VERY DIFFERENT. 1687 01:13:39,381 --> 01:13:49,691 WE DON'T SEE EFFECTS LIKE 1688 01:13:49,758 --> 01:13:50,025 ENDOCARDITIS. 1689 01:13:50,092 --> 01:13:54,429 IN AREAS NOT CONSOLIDATED AND 1690 01:13:54,496 --> 01:14:00,602 HEAVILY CONSOLIDATED WITH 1691 01:14:00,669 --> 01:14:03,505 PNEUMONIA YOU SEE THE LYMPHOID 1692 01:14:03,572 --> 01:14:05,340 TISSUES MORE PARENT. 1693 01:14:05,407 --> 01:14:15,951 WE PUBLISHED -- MORE A PAIR ADID 1694 01:14:19,855 --> 01:14:25,127 APP 1695 01:14:25,194 --> 01:14:26,428 APPARENT AND MY BOSS ALWAYS TOLD 1696 01:14:26,495 --> 01:14:33,735 ME IF YOU GET TWO THINGS ACROSS 1697 01:14:33,802 --> 01:14:35,170 YO 1698 01:14:35,237 --> 01:14:39,775 YOU'RE YOUR NAME, MY NAME IS 1699 01:14:39,842 --> 01:14:42,277 MICHAEL YEAGER AND INFECTION 1700 01:14:42,344 --> 01:14:45,013 WITH A VARIETY OF BUGS IN THE 1701 01:14:45,080 --> 01:14:46,415 LUNG RELEASES LUNG TAU WHEN GOES 1702 01:14:46,481 --> 01:14:47,983 TO THE BRAIN AND REDUCES 1703 01:14:48,050 --> 01:14:48,250 COGNITION. 1704 01:14:48,317 --> 01:14:50,419 OUR STUDY WASN'T POWERED TO SEE 1705 01:14:50,485 --> 01:14:51,753 IT IN THE BRAIN BECAUSE WE 1706 01:14:51,820 --> 01:14:56,091 DIDN'T COLLECT BRAINS THAIN THA 1707 01:14:56,158 --> 01:14:58,126 WAY BUT IN THE HEART, LUNG AND 1708 01:14:58,193 --> 01:15:00,996 PLASMA OF CONTROLS ANIMALS WE 1709 01:15:01,063 --> 01:15:04,933 WEREN'T EMPOWERED BUT WE SEE 1710 01:15:05,000 --> 01:15:06,935 RELEASE OF LUNG TAU. 1711 01:15:07,002 --> 01:15:09,771 AND SO WHAT THIS SUGGESTS AND I 1712 01:15:09,838 --> 01:15:11,740 DON'T READ TAKE-HOME MESSAGES 1713 01:15:11,807 --> 01:15:13,308 I'LL SKIP TO THE END BECAUSE I 1714 01:15:13,375 --> 01:15:14,309 ALREADY HIGHLIGHTED THIS. 1715 01:15:14,376 --> 01:15:16,845 THIS RAISES THIS INTRIGUING 1716 01:15:16,912 --> 01:15:18,614 POSSIBILITY THAT RECURRENT LUNG 1717 01:15:18,680 --> 01:15:21,750 INFECTION AND DOWN SYNDROME 1718 01:15:21,817 --> 01:15:25,687 COULD CONTRIBUTE TO DECREASED 1719 01:15:25,754 --> 01:15:25,954 COGNITION. 1720 01:15:26,021 --> 01:15:29,424 MANY STUDIES SHOW IN RECURRENT 1721 01:15:29,491 --> 01:15:31,493 RESPIRATORY TRACT INFECTION WITH 1722 01:15:31,560 --> 01:15:33,528 PEOPLE WITH DOWN SYNDROME THEY 1723 01:15:33,595 --> 01:15:35,631 ALL SCORE LOWER IN COGNITIVE 1724 01:15:35,697 --> 01:15:36,064 ASSAYS. 1725 01:15:36,131 --> 01:15:38,400 THERE'S A STUDY FROM DENMARK 1726 01:15:38,467 --> 01:15:39,067 ABOUT 10 YEARS AGO THAT SHOWS 1727 01:15:39,134 --> 01:15:40,469 THIS. 1728 01:15:40,535 --> 01:15:41,904 THE OTHER THING I'D LIKE TO 1729 01:15:41,970 --> 01:15:43,872 POINT OUT, I DIDN'T HAVE TIME TO 1730 01:15:43,939 --> 01:15:45,908 TALK ABOUT THE ARNO RAT MODELS 1731 01:15:45,974 --> 01:15:47,743 BUT WE WERE CLEVER I THOUGHT AND 1732 01:15:47,809 --> 01:15:48,310 MADE THOSE IN TWO DIFFERENT 1733 01:15:48,377 --> 01:15:53,115 STRAINS. 1734 01:15:53,181 --> 01:15:54,683 WE SEE STRAIN DIFFERENCE IN THE 1735 01:15:54,750 --> 01:15:55,250 RATS. 1736 01:15:55,317 --> 01:15:58,420 I'D LIKE TO TO POINT OUT 1737 01:15:58,487 --> 01:15:59,955 ANYTHING DIFFERENCES OBSERVED IN 1738 01:16:00,022 --> 01:16:02,357 THE DP16 MICE MAY BE DEPENDENT 1739 01:16:02,424 --> 01:16:02,658 TOO. 1740 01:16:02,724 --> 01:16:06,194 THE MESSAGE WE GOT FROM OUR 1741 01:16:06,261 --> 01:16:08,830 GREAT FIRST SPEAKER IS THERE'S A 1742 01:16:08,897 --> 01:16:09,765 LOT OF INDIVIDUALISM IN DOWN 1743 01:16:09,831 --> 01:16:10,198 SYNDROME. 1744 01:16:10,265 --> 01:16:14,336 I'D LIKE TO THANK MY TEAM, AND 1745 01:16:14,403 --> 01:16:19,841 ESPECIALLY KELLY CALDWIN AND MY 1746 01:16:19,908 --> 01:16:21,276 SISTER, AMY AND HOW TO EVERYBODY 1747 01:16:21,343 --> 01:16:22,210 WHO DOES THIS AND ALL OUR 1748 01:16:22,277 --> 01:16:22,444 FUNDERS. 1749 01:16:22,511 --> 01:16:32,688 THANK YOU. 1750 01:16:44,633 --> 01:16:47,302 >> IF YOU HAVE QUESTIONS FOR HIM 1751 01:16:47,369 --> 01:16:48,737 YOU'LL GET TO ASK QUESTIONS AT 1752 01:16:48,804 --> 01:16:52,574 THE END OF THE PRESENTATIONS. 1753 01:16:52,641 --> 01:16:54,409 OUR NEXT SPEAKER IS DR. JENNIFER 1754 01:16:54,476 --> 01:17:04,653 LAWRENCE. 1755 01:17:26,708 --> 01:17:31,847 >> TO CONTINUE TO LOOKING AT THE 1756 01:17:31,913 --> 01:17:34,883 SCIENTIFIC QUESTIONS RELATED TO 1757 01:17:34,950 --> 01:17:38,420 DOWN SYNDROME. 1758 01:17:38,487 --> 01:17:48,730 DR. LAWRENCE. 1759 01:17:53,335 --> 01:17:56,872 >> THANK YOU. 1760 01:17:56,938 --> 01:18:00,275 I DO WANT TO THANK THE INCLUDE 1761 01:18:00,342 --> 01:18:03,879 ORGANIZERS FOR INVITING ME AND 1762 01:18:03,945 --> 01:18:05,013 FOR THEIR WHOLE GROWTH AND 1763 01:18:05,080 --> 01:18:07,416 SUPPORT IN THIS AREA OF RESEARCH 1764 01:18:07,482 --> 01:18:09,117 WHICH HAS BEEN PHENOMENAL. 1765 01:18:09,184 --> 01:18:13,088 I'M GOING TO TALK TO YOU TODAY 1766 01:18:13,155 --> 01:18:16,358 ABOUT KIND OF A VERY DIFFERENT 1767 01:18:16,425 --> 01:18:18,060 TYPE OF APPROACH THAN A LOT OF 1768 01:18:18,126 --> 01:18:20,362 STUDIES IN DOWN SYNDROME BUT ONE 1769 01:18:20,429 --> 01:18:22,330 THAT I HOPE IN DISCUSSION WE'LL 1770 01:18:22,397 --> 01:18:25,200 HAVE TIME TO TALK ABOUT COULD BE 1771 01:18:25,267 --> 01:18:27,302 COULD BE MAYBE EMPLOYED MORE AND 1772 01:18:27,369 --> 01:18:29,171 MY GROUP WILL BE HAPPY TO HELP 1773 01:18:29,237 --> 01:18:32,707 PEOPLE WHO MIGHT WANT TO 1774 01:18:32,774 --> 01:18:35,010 INTRODUCE THIS INTO THEIR OWN 1775 01:18:35,077 --> 01:18:35,277 RESEARCH. 1776 01:18:35,343 --> 01:18:38,413 WE'RE TRYING TO USE FUNDAMENTAL 1777 01:18:38,480 --> 01:18:39,815 EPIGENETIC MECHANISM OF EXIST 1778 01:18:39,881 --> 01:18:42,984 RNA WHICH SILENCING ONE X 1779 01:18:43,051 --> 01:18:43,952 CHROMOSOME IN FEMALES. 1780 01:18:44,019 --> 01:18:48,790 WE'RE TRYING TO TAKE THAT AND 1781 01:18:48,857 --> 01:18:51,827 APPLY IT TO TRISOMY 21 AND GROW 1782 01:18:51,893 --> 01:18:55,597 THE IDEA IT'S BROADLY APPLICABLE 1783 01:18:55,664 --> 01:19:06,108 TO CHROMOSOMAL IMBALANCES. 1784 01:19:11,813 --> 01:19:14,216 WE BASICALLY SHOWED THAT WAS THE 1785 01:19:14,282 --> 01:19:16,485 CASE AND EVERYTHING I'M GOING TO 1786 01:19:16,551 --> 01:19:21,857 SHOW YOU IS FUNDED THROUGH THE 1787 01:19:21,923 --> 01:19:23,758 INCLUDE OR NICHD NOW. 1788 01:19:23,825 --> 01:19:25,760 THIS WAS ORIGINALLY SUPPORTED BY 1789 01:19:25,827 --> 01:19:29,598 AN EUREKA GRANT FROM THE NIGMS. 1790 01:19:29,664 --> 01:19:32,567 SO THIS IS THE RNA CODING ONE OF 1791 01:19:32,634 --> 01:19:39,441 THREE CHROMOSOMES 21 AND IT 1792 01:19:39,508 --> 01:19:44,546 SILENCING IT AND IF YOU CAN 1793 01:19:44,613 --> 01:19:51,086 SILENCE AND IF YOU CAN SILENCE 1794 01:19:51,153 --> 01:19:52,154 IT FROM AN INDIVIDUAL WITH DOWN 1795 01:19:52,220 --> 01:19:55,624 SYNDROME WHAT CAN YOU DO WITH 1796 01:19:55,690 --> 01:19:55,891 THAT? 1797 01:19:55,957 --> 01:19:58,059 AND THIS IS DESCRIBED IN AN 1798 01:19:58,126 --> 01:19:59,227 ARTICLE AND OUR FIRST THING IS 1799 01:19:59,294 --> 01:20:01,329 WE'RE TRYING TO USE THIS AS AN 1800 01:20:01,396 --> 01:20:03,832 EXPERIMENTAL SYSTEM TO 1801 01:20:03,899 --> 01:20:09,171 MANIPULATE CHROMOSOME 21 AND 1802 01:20:09,237 --> 01:20:16,711 UNDERSTAND THE ROOT CAUSES OF 1803 01:20:16,778 --> 01:20:23,185 PHENOTYPES AND ALSO HAS A 1804 01:20:23,251 --> 01:20:28,190 REVOLUTIONARY POTENTIAL THAT CAN 1805 01:20:28,256 --> 01:20:30,892 BE DEVELOPED INTO A THERAPEUTIC. 1806 01:20:30,959 --> 01:20:36,431 OR CELLS THAT ARE BASICALLY 1807 01:20:36,498 --> 01:20:37,832 CHROMOSOME SILENCED OUTSIDE THE 1808 01:20:37,899 --> 01:20:39,701 BODY COULD BE INTRODUCED AS A 1809 01:20:39,768 --> 01:20:40,001 THERAPEUTIC. 1810 01:20:40,068 --> 01:20:42,404 I WANT TO SAY A LITTLE BIT ABOUT 1811 01:20:42,470 --> 01:20:53,014 WHY AN INDUCIBLE SYSTEM IS HAS 1812 01:20:53,615 --> 01:20:54,382 ADVANTAGES OVER CELL LINES EVEN 1813 01:20:54,449 --> 01:20:57,018 IF THEY'RE ISO GENIC. 1814 01:20:57,085 --> 01:20:59,721 I'M AN EPIGENETICISTS AND I'VE 1815 01:20:59,788 --> 01:21:05,126 KNOWN THE CELLS CHANGE IN 1816 01:21:05,193 --> 01:21:05,393 CULTURE. 1817 01:21:05,460 --> 01:21:12,000 AND SO THERE'S DIFFERENCES AND 1818 01:21:12,067 --> 01:21:14,970 WHAT IS DUE TO OVEREXPRESSION OF 1819 01:21:15,036 --> 01:21:16,371 CHROMOSOME 21. 1820 01:21:16,438 --> 01:21:18,840 I APPRECIATE THE PRIOR TALK BY 1821 01:21:18,907 --> 01:21:26,348 DR. YEAGER TALKING ABOUT VARIANT 1822 01:21:26,414 --> 01:21:30,418 -- VARIABILITY AND JUST TALK 1823 01:21:30,485 --> 01:21:32,320 ABOUT CHROMOSOME 21 AND THE 1824 01:21:32,387 --> 01:21:33,855 PAPER DISCUSSES ORGANOIDS AND 1825 01:21:33,922 --> 01:21:35,890 THE APPLICATION OF THAT TO 1826 01:21:35,957 --> 01:21:36,858 DIFFERENT CELL LINES AND YOU CAN 1827 01:21:36,925 --> 01:21:40,428 LOOK AT THAT. 1828 01:21:40,495 --> 01:21:44,966 SO WE'RE LOOKING FOR MORE DIRECT 1829 01:21:45,033 --> 01:21:47,102 INFECTS AND INDUCIBILITY ALLOWS 1830 01:21:47,168 --> 01:21:48,036 YOU TO INDUCE THE CORRECTION 1831 01:21:48,103 --> 01:21:49,804 LATER IN DEVELOPMENT TO SEE WHAT 1832 01:21:49,871 --> 01:21:52,674 THE EFFECTS ARE OF THAT. 1833 01:21:52,741 --> 01:21:57,846 IT ALLOWS YOU TO LOOK AT 1834 01:21:57,912 --> 01:22:02,017 DEVELOPMENTAL TIMING. 1835 01:22:02,083 --> 01:22:04,719 AND THE FIRST THING WE DID WAS 1836 01:22:04,786 --> 01:22:09,024 SAY, OKAY, IF YOU CAN SILENCE 1837 01:22:09,090 --> 01:22:12,260 ONE CHROMOSOME 21, DOES THAT 1838 01:22:12,327 --> 01:22:13,695 CORRECT THE CELL FUNCTION IN 1839 01:22:13,762 --> 01:22:13,995 DEVELOPMENT. 1840 01:22:14,062 --> 01:22:15,997 IN ORDER TO ADDRESS THAT WE DID 1841 01:22:16,064 --> 01:22:26,541 IT IN THE HEMATOPOINT -- 1842 01:22:39,120 --> 01:22:42,023 HEMATOPOIETIC SYSTEM AND IT 1843 01:22:42,090 --> 01:22:42,724 FORMS A NEURON. 1844 01:22:42,791 --> 01:22:44,993 THIS WAS SHOWN IN MULTIPLE WAYS 1845 01:22:45,060 --> 01:22:45,860 IN THIS PAPER. 1846 01:22:45,927 --> 01:22:47,462 THIS PAPER ALSO SHOWED YOU CAN 1847 01:22:47,529 --> 01:22:49,030 INTRODUCE SILENCING LATER IN 1848 01:22:49,097 --> 01:22:50,432 DEVELOPMENT WHICH WAS NOT KNOWN 1849 01:22:50,498 --> 01:22:52,567 AT THE TIME AND WE THOUGHT TO 1850 01:22:52,634 --> 01:23:00,375 NOT BE THE WAY IT WAS. 1851 01:23:00,442 --> 01:23:06,414 AND ANOTHER STUDENT IF THE LAB 1852 01:23:06,481 --> 01:23:09,050 STUDIED WHAT HAPPENS AND IT LED 1853 01:23:09,117 --> 01:23:11,586 HER TO ANGIOGENESIS AND THE 1854 01:23:11,653 --> 01:23:12,620 PREVIOUS TALKED ABOUT 1855 01:23:12,687 --> 01:23:15,890 HYPERTENSION AND WE THOUGHT THE 1856 01:23:15,957 --> 01:23:18,827 ANGIOGENIC PHENOTYPE WAS NOT 1857 01:23:18,893 --> 01:23:21,396 NECESSARY AND WE WERE DOING 1858 01:23:21,463 --> 01:23:22,430 TABLEAU ROSA WHICH WE SEE. 1859 01:23:22,497 --> 01:23:26,801 WE DETECTED THIS. 1860 01:23:26,868 --> 01:23:28,703 SO AND THIS WAS PUBLISHED AND I 1861 01:23:28,770 --> 01:23:30,438 WAS TRANSITIONED TO THINGS THAT 1862 01:23:30,505 --> 01:23:34,209 AREN'T. 1863 01:23:34,275 --> 01:23:35,844 SO THE GENE PATHWAYS THAT WE SAW 1864 01:23:35,910 --> 01:23:40,315 AFFECTED ARE SHOWN HERE. 1865 01:23:40,382 --> 01:23:42,083 AND THE TWO CELL TYPES AFFECTED 1866 01:23:42,150 --> 01:23:42,884 ARE THESE. 1867 01:23:42,951 --> 01:23:46,054 I WANT TO POINT OUT THAT IN ALL 1868 01:23:46,121 --> 01:23:49,557 OF OUR DATA NOT SIGNALLING SEEMS 1869 01:23:49,624 --> 01:23:51,593 TO BE INCREASED IN THE TRISOMIC 1870 01:23:51,659 --> 01:23:54,262 CELLS AND WHEN WE SILENCE THE 1871 01:23:54,329 --> 01:23:55,563 CHROMOSOME IT DECREASED. 1872 01:23:55,630 --> 01:24:02,103 IF WE SILENCE THE ANGIOGENIC 1873 01:24:02,170 --> 01:24:03,905 RESPONSE IN FORMATION OF 1874 01:24:03,972 --> 01:24:06,040 MICROVESSELS GOES UP AND 1875 01:24:06,107 --> 01:24:08,209 NON-SIGNALLING GOES DOWN. 1876 01:24:08,276 --> 01:24:11,045 NOW I'LL SORT OF GIVE YOU A 1877 01:24:11,112 --> 01:24:12,647 TASTE OF THREE DIFFERENT NOVEL 1878 01:24:12,714 --> 01:24:15,884 EXTENSIONS OF THIS APPROACH. 1879 01:24:15,950 --> 01:24:16,918 WE'RE CURRENTLY WORKING ON THAT 1880 01:24:16,985 --> 01:24:18,720 ARE UNPUBLISHED. 1881 01:24:18,787 --> 01:24:22,290 FIRST, IS TO IDENTIFY A MINI 1882 01:24:22,357 --> 01:24:26,428 GENE, A SMALL GENE THAT SILENCES 1883 01:24:26,494 --> 01:24:26,895 PART OF CHROMOSOME 21. 1884 01:24:26,961 --> 01:24:28,696 THE OTHER IS TO I WANT TO 1885 01:24:28,763 --> 01:24:30,231 MENTION WE THINK THIS APPROACH 1886 01:24:30,298 --> 01:24:33,902 COULD CONTRIBUTE TO THE STUDY OF 1887 01:24:33,968 --> 01:24:37,639 POLYMORPHISMS BY SELECTIVELY 1888 01:24:37,705 --> 01:24:39,941 SILENCING DIFFERENT HOMO LOGS 1889 01:24:40,008 --> 01:24:41,743 AND WE'RE WORKING ON PUTTING 1890 01:24:41,810 --> 01:24:43,445 THIS INTO A MOUSE. 1891 01:24:43,511 --> 01:24:46,014 WE CREATED A MOUSE WITH SOME OF 1892 01:24:46,080 --> 01:24:46,281 THIS. 1893 01:24:46,347 --> 01:24:52,454 SO THE GOAL OF THIS WAS TO 1894 01:24:52,520 --> 01:24:56,724 REDUCE THE SIZE EXIST 14RNA AND 1895 01:24:56,791 --> 01:25:02,096 IF YOU WANT TO USE IT 1896 01:25:02,163 --> 01:25:05,233 THERAPEUTICALLY IT CAN'T BE USED 1897 01:25:05,300 --> 01:25:09,337 IN THAT FORM AND WE MADE A MINI 1898 01:25:09,404 --> 01:25:10,772 GENE OUT OF THE REPEAT AND 1899 01:25:10,839 --> 01:25:15,910 MAKING OTHER MINI GENES WITH 1900 01:25:15,977 --> 01:25:20,615 OTHER MROPROPERTIES AND WHAT YO 1901 01:25:20,682 --> 01:25:25,153 SEE IS THE MINI GENE RNA DIDN'T 1902 01:25:25,220 --> 01:25:30,525 COAT THE CHROMOSOME. 1903 01:25:30,592 --> 01:25:33,895 BOTTOM LINE IT LOCALIZE TO THE 1904 01:25:33,962 --> 01:25:35,964 DOWN SYNDROME CRITICAL REGION 1905 01:25:36,030 --> 01:25:42,403 BECAUSE WE INSERTED IT AND IN 1906 01:25:42,470 --> 01:25:45,473 THE DOESN'T INCREASE THE UNLESS 1907 01:25:45,540 --> 01:25:46,307 WE INCREASE THE RNA. 1908 01:25:46,374 --> 01:25:48,176 WHAT WE'RE DOING IS STUDIES THE 1909 01:25:48,243 --> 01:25:54,015 EFFECTS OF THAT MINI GENE ON 1910 01:25:54,082 --> 01:26:00,288 OTHER -- OTHER GENES AND HERE 1911 01:26:00,355 --> 01:26:02,957 IT'S REPRESSED AND OTHER GENES 1912 01:26:03,024 --> 01:26:07,362 NEAR IT WERE REPRESSED AND WE 1913 01:26:07,428 --> 01:26:09,397 WERE TRYING TO MAKE THE MINI 1914 01:26:09,464 --> 01:26:13,334 GENES AND WE'RE CURRENTLY 1915 01:26:13,401 --> 01:26:14,936 WORKING ON RNA SEQ AND ERIC 1916 01:26:15,003 --> 01:26:16,604 LARSON IN MY LAB IS LEADING 1917 01:26:16,671 --> 01:26:16,871 THAT. 1918 01:26:16,938 --> 01:26:20,708 THIS IS JUST AN EXAMPLE OF THIS 1919 01:26:20,775 --> 01:26:23,311 IS THE REGION WITH THE WHOLE 1920 01:26:23,378 --> 01:26:25,580 CHROMOSOME AND THIS IS JUST THE 1921 01:26:25,647 --> 01:26:26,981 MINI GENE. 1922 01:26:27,048 --> 01:26:30,418 YOU SEE THAT IT'S EFFECTING A 1923 01:26:30,485 --> 01:26:35,657 REGION WE THINK IS AROUND 2 TO 5 1924 01:26:35,723 --> 01:26:36,491 MEGA BASIS. 1925 01:26:36,558 --> 01:26:38,626 TO SHOW EXAMPLES OF WHAT THE 1926 01:26:38,693 --> 01:26:41,462 DATA LOOKS LIKE, THIS ISO GENIC 1927 01:26:41,529 --> 01:26:44,065 IS A CONTROL. 1928 01:26:44,132 --> 01:26:47,635 IF WE PUT DOCKS ON THE CELLS IT 1929 01:26:47,702 --> 01:26:49,304 HAS A LITTLE AFFECT BUT WE HAVE 1930 01:26:49,370 --> 01:26:50,638 TO DO THAT BECAUSE IT DOES 1931 01:26:50,705 --> 01:26:51,873 AFFECT SOME GENES. 1932 01:26:51,940 --> 01:26:54,309 HERE'S THE APP GENE FAR AWAY 1933 01:26:54,375 --> 01:26:56,110 FROM THE DOWN SYNDROME CRITICAL 1934 01:26:56,177 --> 01:27:01,149 REGION AND WHEN WE DO A 1935 01:27:01,215 --> 01:27:03,017 FULL-LENGTH SILENCING, OR MINI 1936 01:27:03,084 --> 01:27:04,218 GENE IT DOESN'T. 1937 01:27:04,285 --> 01:27:05,520 AND HERE'S A DIFFERENT GENE. 1938 01:27:05,587 --> 01:27:08,256 THIS IS DSCR3 AND THAT'S 1939 01:27:08,323 --> 01:27:09,891 REPRESSED BECAUSE IT'S IN THE 1940 01:27:09,958 --> 01:27:17,332 REGION. 1941 01:27:17,398 --> 01:27:18,933 THESE ARE COMPARING OTHER GENES 1942 01:27:19,000 --> 01:27:21,903 AND THIS GOES DOWN WITH OTHER 1943 01:27:21,970 --> 01:27:24,739 MINI GENES AND THIS ONE GOES 1944 01:27:24,806 --> 01:27:30,411 DOWN MORE MODESTLY 1.5 MEGA 1945 01:27:30,478 --> 01:27:32,146 BASES AND THIS ONE DOESN'T GO 1946 01:27:32,213 --> 01:27:32,814 DOWN AT ALL. 1947 01:27:32,880 --> 01:27:34,882 THERE MAY BE SOME THAT DON'T GO 1948 01:27:34,949 --> 01:27:36,150 DOWN IN THE REGION. 1949 01:27:36,217 --> 01:27:38,886 NOW WE'RE USING THIS APPROACH TO 1950 01:27:38,953 --> 01:27:41,122 SAY HOW DOES REPRESSION OF JUST 1951 01:27:41,189 --> 01:27:45,226 GENES IN THE DSCR REGION IMPACT 1952 01:27:45,293 --> 01:27:46,361 GENOME-WIDE PATHWAYS? 1953 01:27:46,427 --> 01:27:52,233 I'LL SHOW A FEW EXAMPLES. 1954 01:27:52,300 --> 01:27:57,472 SO SOME CHROMOSOME 21 GENES IF 1955 01:27:57,538 --> 01:27:59,207 WE SILENCE JUST THAT REGION IT 1956 01:27:59,273 --> 01:28:00,708 LOOKS SIMILAR TO THE DATA IF YOU 1957 01:28:00,775 --> 01:28:02,777 SILENCE THE WHOLE CHROMOSOME. 1958 01:28:02,844 --> 01:28:04,412 HERE'S FULL CHROMOSOME AND TWO 1959 01:28:04,479 --> 01:28:04,712 MINI GENES. 1960 01:28:04,779 --> 01:28:07,415 AS I MENTIONED, NOT SIGNALLING 1961 01:28:07,482 --> 01:28:08,883 IS A THEME THAT KEEPS COMING UP 1962 01:28:08,950 --> 01:28:10,418 IN OUR WORK. 1963 01:28:10,485 --> 01:28:12,086 THIS GENE'S IMPORTANT IN NOT 1964 01:28:12,153 --> 01:28:12,820 SIGNALLING. 1965 01:28:12,887 --> 01:28:20,495 THIS IS OUR CONTROL FOR THE 1966 01:28:20,561 --> 01:28:22,196 DOCKS AFFECTS OTHERS WILL REDUCE 1967 01:28:22,263 --> 01:28:24,732 IN THE MINI GENES BUT NOT AS 1968 01:28:24,799 --> 01:28:26,034 FULLY AS THE FULL LENGTH. 1969 01:28:26,100 --> 01:28:28,603 THIS APPROACH IN ALL THESE GENES 1970 01:28:28,670 --> 01:28:30,171 ARE INVOLVED IN NOT. 1971 01:28:30,238 --> 01:28:33,441 WE FIND SURPRISINGLY A FEW 1972 01:28:33,508 --> 01:28:35,276 NON-CHROMOSOME 21 GENES DECREASE 1973 01:28:35,343 --> 01:28:36,978 MORE IF YOU SILENCE JUST THAT 1974 01:28:37,045 --> 01:28:41,249 PART OF THE CHROMOSOME THAN IF 1975 01:28:41,315 --> 01:28:43,951 YOU SILENCE THESE ARE OF THE 1976 01:28:44,018 --> 01:28:52,360 CHROMOSOME 21 GENES AND THIS MAY 1977 01:28:52,427 --> 01:28:54,429 REFLECT DISRUPTION OF THE 1978 01:28:54,495 --> 01:28:56,764 BALANCE OF GENES ON CHROMOSOME 1979 01:28:56,831 --> 01:28:56,931 21. 1980 01:28:56,998 --> 01:28:59,600 NOW WE'VE -- THEY'RE NOT AN 1981 01:28:59,667 --> 01:29:00,868 EQUAL DOSAGE ANYMORE. 1982 01:29:00,935 --> 01:29:01,302 OKAY. 1983 01:29:01,369 --> 01:29:03,571 SO YOU CAN THEN APPLY THIS 1984 01:29:03,638 --> 01:29:04,906 APPROACH TO DIFFERENT PATHWAYS 1985 01:29:04,972 --> 01:29:07,308 TO SAY WHAT PATHWAYS ARE 1986 01:29:07,375 --> 01:29:11,245 AFFECTED IF WE REPRESS THE WHOLE 1987 01:29:11,312 --> 01:29:13,381 CHROMOSOME VERSUS THE TWO MINI 1988 01:29:13,448 --> 01:29:14,382 GENES. 1989 01:29:14,449 --> 01:29:18,352 YOU CAN SEE CARDIAC SEPTUM 1990 01:29:18,419 --> 01:29:21,923 COUPLES AND ANGIOGENESIS COMES 1991 01:29:21,989 --> 01:29:24,926 UP AND INTERESTING RIBOSOME ARE 1992 01:29:24,992 --> 01:29:30,431 FAR FROM OUR MINI GENE. 1993 01:29:30,498 --> 01:29:33,568 I WANT TO MENTION THE IDEA -- I 1994 01:29:33,634 --> 01:29:34,602 DON'T KNOW HOW MANY TIME I HAVE 1995 01:29:34,669 --> 01:29:37,972 BUT WE THINK THE APPROACH CAN BE 1996 01:29:38,039 --> 01:29:39,941 EXTENDED TO AT LEAST BE A 1997 01:29:40,007 --> 01:29:50,418 COMPLIMENT TO GENOME STUDIES OF 1998 01:29:50,485 --> 01:29:51,219 POLYMORPHISMS. 1999 01:29:51,285 --> 01:29:53,955 AND EXPRESSION POLYMORPHISMS ON 2000 01:29:54,021 --> 01:29:54,422 CHROMOSOME 21 MAY BE 2001 01:29:54,489 --> 01:30:03,030 PARTICULARLY IMPORTANT. 2002 01:30:03,097 --> 01:30:07,602 WE CAN SILENCE THE CHROMOSOMES 2003 01:30:07,668 --> 01:30:09,704 WHICH ARE GENETICALLY DISTINCT 2004 01:30:09,771 --> 01:30:11,839 AND WE HAVE A PANEL OF CELLS 2005 01:30:11,906 --> 01:30:13,841 THAT SILENCE DIFFERENCE ONES. 2006 01:30:13,908 --> 01:30:16,544 BY LOOKING AT DIFFERENT DATA 2007 01:30:16,611 --> 01:30:19,947 FROM SILENCING DIFFERENT 2008 01:30:20,014 --> 01:30:23,818 CHROMOSOME 21s, WE DISCOVERED A 2009 01:30:23,885 --> 01:30:27,655 GENE THAT STRONGLY IS GOVERN A 2010 01:30:27,722 --> 01:30:30,424 POLYMORPHISM BY ONE OF THE 2011 01:30:30,491 --> 01:30:32,593 CHROMOSOME AND THAT IS STRONG 2012 01:30:32,660 --> 01:30:34,061 AND I WON'T TALK ABOUT IT TODAY 2013 01:30:34,128 --> 01:30:36,464 BECAUSE ERIC STILL WORKING ON 2014 01:30:36,531 --> 01:30:38,299 THAT BUT WE'RE LOOKING TO SEE 2015 01:30:38,366 --> 01:30:40,968 WHETHER THIS APPROACH COULD BE 2016 01:30:41,035 --> 01:30:42,537 APPLIED TO OTHER POLYMORPHISMS 2017 01:30:42,603 --> 01:30:44,405 THAT MAY HAVE A MILDER EFFECT. 2018 01:30:44,472 --> 01:30:47,675 AND WE THINK IF IT'S JUST 2019 01:30:47,742 --> 01:30:48,509 EXPANDING BECAUSE WE JUST DID 2020 01:30:48,576 --> 01:30:51,646 THIS IN OUR EXISTING DATA, IF 2021 01:30:51,712 --> 01:30:54,415 YOU EXPAND THIS TO A LITTLE BIT 2022 01:30:54,482 --> 01:31:00,321 MORE POWERFUL, YOU CAN TELL THIS 2023 01:31:00,388 --> 01:31:03,724 OFF GENES AND THIS AFFECTS IT 2024 01:31:03,791 --> 01:31:04,592 DIFFERENTLY THAN THESE. 2025 01:31:04,659 --> 01:31:05,726 THAT'S JUST AN EXAMPLE. 2026 01:31:05,793 --> 01:31:12,400 I WANT TO END -- I'M NOT SURE 2027 01:31:12,466 --> 01:31:13,668 MUCH TIME I HAVE BUT WE'RE 2028 01:31:13,734 --> 01:31:15,670 WORKING TO TRANSFER ALL THIS 2029 01:31:15,736 --> 01:31:17,672 INTO A MOUSE IN VIVO MODEL AND 2030 01:31:17,738 --> 01:31:19,407 WE'RE WORKING IN TWO WAYS. 2031 01:31:19,473 --> 01:31:21,075 ONE IS WITH THE EXIST MINI GENES 2032 01:31:21,142 --> 01:31:26,347 AND ONE IS WITH THE FULL-LENGTH 2033 01:31:26,414 --> 01:31:26,547 EXIST. 2034 01:31:26,614 --> 01:31:31,886 AND WE MADE A WHOLE TS65DN MOUSE 2035 01:31:31,953 --> 01:31:34,455 AND IT'S IN JACKSON LABS. 2036 01:31:34,522 --> 01:31:35,723 IT'S GOT A TECHNICAL ISSUE I'LL 2037 01:31:35,790 --> 01:31:37,058 TELL YOU ABOUT IF YOU WANT TO 2038 01:31:37,124 --> 01:31:38,392 ASK BUT THAT MOUSE IS FREELY 2039 01:31:38,459 --> 01:31:42,396 AVAILABLE. 2040 01:31:42,463 --> 01:31:44,832 THE GOAL WAS TO TEST FULL LENGTH 2041 01:31:44,899 --> 01:31:51,739 EXIST AND WE HAVE CREATED A MINI 2042 01:31:51,806 --> 01:31:57,678 GENE MOUSE AND THAT RNA IS 2043 01:31:57,745 --> 01:31:59,413 EXPRESSED AND REPRESSING PART OF 2044 01:31:59,480 --> 01:32:00,381 THE CHROMOSOME SO WE'RE 2045 01:32:00,448 --> 01:32:03,885 CURRENTLY STUDYING THAT MOUSE. 2046 01:32:03,951 --> 01:32:05,920 MICE WILL BORN IN UNEXPECTED 2047 01:32:05,987 --> 01:32:07,889 RATIO AND BRED THEM OVER A YEAR. 2048 01:32:07,955 --> 01:32:12,426 WE ALSO GENERATED CHIMERIC MICE 2049 01:32:12,493 --> 01:32:15,696 AND BREEDING THOSE FOR 2050 01:32:15,763 --> 01:32:18,099 FULL-LENGTH EXIST. 2051 01:32:18,165 --> 01:32:19,700 SO I'M GOING STOP THERE AND CAN 2052 01:32:19,767 --> 01:32:20,234 TELL YOU MORE DURING THE 2053 01:32:20,301 --> 01:32:21,235 DISCUSSION. 2054 01:32:21,302 --> 01:32:30,778 THANK YOU VERY MUCH. 2055 01:32:30,845 --> 01:32:35,917 >> THANK YOU, DR. LAURENCE. 2056 01:32:35,983 --> 01:32:38,419 OUR THIRD SPEAKER IS COMING UP 2057 01:32:38,486 --> 01:32:48,696 THE STAIRS. 2058 01:33:09,483 --> 01:33:10,885 I'M GOING INTRODUCE DR. I'LL LET 2059 01:33:10,952 --> 01:33:14,455 YOU SAY YOUR OWN NAME. 2060 01:33:14,522 --> 01:33:17,992 I'M SORRY. 2061 01:33:18,059 --> 01:33:19,427 >> WE'RE NOT GOING MAKE THIS AT 2062 01:33:19,493 --> 01:33:19,727 THE END. 2063 01:33:19,794 --> 01:33:20,995 THANK YOU FOR YOUR TIME. 2064 01:33:21,062 --> 01:33:23,030 I WANT TO THANK YOU THE INCLUDE 2065 01:33:23,097 --> 01:33:25,266 TEAM AND THE OPPORTUNITY TO BE 2066 01:33:25,333 --> 01:33:26,968 HERE AND PRESENT OUR WORK. 2067 01:33:27,034 --> 01:33:29,804 WHAT I WANT TO PRESENT IS ON THE 2068 01:33:29,870 --> 01:33:31,238 PRECLINICAL MODELLING OF DOWN 2069 01:33:31,305 --> 01:33:32,673 SYNDROME AND HAS SOME DIFFERENT 2070 01:33:32,740 --> 01:33:33,975 ANGLE TO SOME OF THE EARLIER 2071 01:33:34,041 --> 01:33:36,911 PRESENTATIONS. 2072 01:33:36,978 --> 01:33:39,480 WHAT WE ARE INTERESTED IN PART 2073 01:33:39,547 --> 01:33:43,351 OF OUR EFFORTS IS UNDERSTANDING 2074 01:33:43,417 --> 01:33:45,152 WITH PEOPLE WITH DOWN SYNDROME 2075 01:33:45,219 --> 01:33:48,589 HAVE A HIGH RATE OF RECURRENT 2076 01:33:48,656 --> 01:33:51,158 INFECTIONS AND PNEUMONIAS AND 2077 01:33:51,225 --> 01:33:54,128 GOING TO THE CARDIO VASCULAR 2078 01:33:54,195 --> 01:33:54,395 PROBLEMS. 2079 01:33:54,462 --> 01:33:56,564 DR. YEAGER PRESENT THE THIS 2080 01:33:56,630 --> 01:33:57,999 EARLIER SO I WON'T GO DOWN THAT 2081 01:33:58,065 --> 01:34:03,371 BUT SPECIFICALLY WHAT IS THE 2082 01:34:03,437 --> 01:34:03,971 IMPACT OF DOWN SYNDROME ON 2083 01:34:04,038 --> 01:34:06,407 BIOLOGY AND FUNCTIONING OF THE 2084 01:34:06,474 --> 01:34:09,043 LUNG AIRWAY. 2085 01:34:09,110 --> 01:34:12,780 THIS IS PRODUCTION AND CAPTURE 2086 01:34:12,847 --> 01:34:14,181 INHALED PARTICLES TO TAKE IT OUT 2087 01:34:14,248 --> 01:34:16,283 THEIR BODY AND WHAT ABOUT THE 2088 01:34:16,350 --> 01:34:19,286 IMMUNE REGULATION AT THE SITE OF 2089 01:34:19,353 --> 01:34:21,989 THE LUNG AND THE PULMONARY 2090 01:34:22,056 --> 01:34:23,958 TISSUE AND THE IMPACT OF DOWN 2091 01:34:24,025 --> 01:34:26,427 SYNDROME ON THE CROSS TALK OF 2092 01:34:26,494 --> 01:34:27,828 ORGANS AND THE CROSS TALK 2093 01:34:27,895 --> 01:34:32,800 BETWEEN LIKE BONE MARROW AND THE 2094 01:34:32,867 --> 01:34:33,367 LUNGS. 2095 01:34:33,434 --> 01:34:41,042 THE TUMORAL SYSTEMS ARE DP6 AND 2096 01:34:41,108 --> 01:34:41,976 ORGAN AND CHIP TECHNOLOGY. 2097 01:34:42,043 --> 01:34:45,212 SO WE STARTED USING THIS WORK I 2098 01:34:45,279 --> 01:34:48,149 GOT PULLED INTO DOWN SYNDROME 2099 01:34:48,215 --> 01:34:51,852 WORK BY DR. ESPINOZA AND STUDY 2100 01:34:51,919 --> 01:34:53,187 THE PATHOLOGIES THAT HAPPENS IN 2101 01:34:53,254 --> 01:34:53,654 DOWN SYNDROME. 2102 01:34:53,721 --> 01:34:58,025 AND THE FIRST THING WAS THAT WE 2103 01:34:58,092 --> 01:35:05,666 STARTED ISOLATING CELLS FROM THE 2104 01:35:05,733 --> 01:35:10,004 LUNGS OF DP16 MICE BECAUSE THEY 2105 01:35:10,071 --> 01:35:16,077 CARRY A LARGE PORTION OF THIS 2106 01:35:16,143 --> 01:35:19,713 CORRESPONDING TO 21 AND 2107 01:35:19,780 --> 01:35:22,016 DIFFERENTIATE THEM AND BECOME 2108 01:35:22,083 --> 01:35:25,553 CD8 EPITHELIA AND IT TAKES WEEKS 2109 01:35:25,619 --> 01:35:29,290 BUT YOU CAN KEEP THEM LONGER IN 2110 01:35:29,356 --> 01:35:30,124 VITRO. 2111 01:35:30,191 --> 01:35:31,859 INITIALLY WE WANTED TO COMPARE 2112 01:35:31,926 --> 01:35:34,361 THE PROCESS WITH GENERATION 2113 01:35:34,428 --> 01:35:36,097 CAPABILITY IN TERMS OF 2114 01:35:36,163 --> 01:35:37,364 FUNCTIONALITY WHEN THE TISSUE'S 2115 01:35:37,431 --> 01:35:37,631 MATURE. 2116 01:35:37,698 --> 01:35:40,234 IN TERMS OF THE BARRIER FUNCTION 2117 01:35:40,301 --> 01:35:42,536 THEY ARE RELATIVELY SIMILAR 2118 01:35:42,603 --> 01:35:44,338 BETWEEN THE DOWN SYNDROME AND 2119 01:35:44,405 --> 01:35:45,639 MODEL AND WILD TYPE. 2120 01:35:45,706 --> 01:35:56,250 WHEN WE HOOK AT THE FREQUENCY OF 2121 01:35:59,520 --> 01:36:02,823 CILIAATED CELLS AND THE CELLS 2122 01:36:02,890 --> 01:36:03,858 HAVE LESS NUMBER OF THE CELLS 2123 01:36:03,924 --> 01:36:04,959 THROUGHOUT THE CULTURE. 2124 01:36:05,025 --> 01:36:09,230 WE VALIDATED THIS BY 2125 01:36:09,296 --> 01:36:11,232 IMMUNOFLUORESCENT STAINING AND 2126 01:36:11,298 --> 01:36:21,775 IT WAS WHAT WE WERE SEEING. 2127 01:36:26,280 --> 01:36:29,016 WHAT ABOUT THE ABILITY AND 2128 01:36:29,083 --> 01:36:39,593 PATTERN OF CILIA AND WE COULD 2129 01:36:43,797 --> 01:36:52,039 SEE IN THE ONE TYPE HAVE YOU A 2130 01:36:52,106 --> 01:36:54,008 DISTRIBUTION AND THIS RANGE HERE 2131 01:36:54,074 --> 01:36:58,846 BUT IN THE DP16 MODEL IT'S 2132 01:36:58,913 --> 01:37:02,683 SKEWED TOWARDS THE LEFT AND WHEN 2133 01:37:02,750 --> 01:37:06,253 YOU LOOK AT THE NUMBERS OF THE 2134 01:37:06,320 --> 01:37:08,956 CILIATED BEATING IS TWO LESS 2135 01:37:09,023 --> 01:37:13,194 THAN WHAT IS YOU HAVE COMPARED 2136 01:37:13,260 --> 01:37:15,663 TO THE WILD TYPE AND THE 2137 01:37:15,729 --> 01:37:19,633 CILIATED GOES UP TO 27 TIMES A 2138 01:37:19,700 --> 01:37:30,177 SECOND AND ONE DP16 IT'S 25. 2139 01:37:35,683 --> 01:37:37,818 AND WE LET THE CELLS PROPEL THAT 2140 01:37:37,885 --> 01:37:39,253 TO SEE WHAT HAPPENS. 2141 01:37:39,320 --> 01:37:41,121 AND IF YOU LOOK AT THE NUMBERS 2142 01:37:41,188 --> 01:37:42,790 THEY'RE RELATIVELY SIMILAR BUT 2143 01:37:42,856 --> 01:37:45,392 IN TERMS OF THE ABILITY AND WHAT 2144 01:37:45,459 --> 01:37:47,928 IS THE RATE IN MICROMETERS PER 2145 01:37:47,995 --> 01:37:49,763 SECOND YOU CAN SEE IT'S 2146 01:37:49,830 --> 01:37:51,498 STATISTICALLY LESS ABILITY 2147 01:37:51,565 --> 01:37:54,368 BETWEEN THE WILD TYPE AND THE 2148 01:37:54,435 --> 01:37:54,568 DP16. 2149 01:37:54,635 --> 01:37:58,038 IN OTHER WORDS, THE DP16 HAVE 2150 01:37:58,105 --> 01:37:59,773 LESS CILIATED CELLS AND LESS 2151 01:37:59,840 --> 01:38:04,778 ABILITY TO BEAT AND THE BEATING 2152 01:38:04,845 --> 01:38:10,150 RATE IS ACTUALLY COMPARED TO AN 2153 01:38:10,217 --> 01:38:12,119 INHALED PATHOGEN IS LESS IT THAN 2154 01:38:12,186 --> 01:38:13,520 THE WILD TYPE. 2155 01:38:13,587 --> 01:38:18,926 WHAT'S IT LOOK LIKE IN IMMUNITY? 2156 01:38:18,993 --> 01:38:21,929 WE COMPARED THE DNA SEQ AND THE 2157 01:38:21,996 --> 01:38:24,098 TRANSCRIPTOME OF THE WILD TYPE 2158 01:38:24,164 --> 01:38:26,433 VERSUS THE DP 16 AND LOOKED AT 2159 01:38:26,500 --> 01:38:30,471 THE CELLS ARE DIFFERENT AND WHEN 2160 01:38:30,537 --> 01:38:34,008 WE LOOK AT THE ENRICHED SETS WE 2161 01:38:34,074 --> 01:38:34,942 FOUND THE GENES RELATED TO 2162 01:38:35,009 --> 01:38:38,145 IMMUNE RESPONSE ARE ACTIVATED. 2163 01:38:38,212 --> 01:38:39,713 NOW, WE SAW THAT AND WERE NOT 2164 01:38:39,780 --> 01:38:41,115 SURPRISED BECAUSE WE EXPECTED TO 2165 01:38:41,181 --> 01:38:43,384 SEE AN IMMUNE OVERACTIVITY IN 2166 01:38:43,450 --> 01:38:44,518 THE CELLS SIMILAR TO THE IMMUNE 2167 01:38:44,585 --> 01:38:46,420 CELLS. 2168 01:38:46,487 --> 01:38:48,789 WHEN WE STUDIED AFFECTING THEM 2169 01:38:48,856 --> 01:38:50,557 WITH THE INFLUENZA VIRUS AND 2170 01:38:50,624 --> 01:38:55,629 USED THE PR8 INFLUENZA VIRUS 2171 01:38:55,696 --> 01:38:58,065 MODEL WE LOOKED AT A DIFFERENT 2172 01:38:58,132 --> 01:39:02,436 SET AND MULTIPLES OF COLORS IS 2173 01:39:02,503 --> 01:39:03,871 BIOLOGICAL REPLICATES AND WE ADD 2174 01:39:03,937 --> 01:39:06,473 THE VARIOUS AND AFTER TWO HOURS 2175 01:39:06,540 --> 01:39:17,051 WE REMOVED THE INNOCULIN AND 2176 01:39:19,687 --> 01:39:22,089 THERE'S NO WAY TO TAKE THE VIRUS 2177 01:39:22,156 --> 01:39:22,256 OUT. 2178 01:39:22,323 --> 01:39:24,591 YOU DON'T HAVE THE FLOW TO WASH 2179 01:39:24,658 --> 01:39:30,030 OUT THE VIRUS AFTER THE SYSTEM. 2180 01:39:30,097 --> 01:39:33,033 AND WE LOOKED AT THE IMMUNE GENE 2181 01:39:33,100 --> 01:39:34,768 EXPRESSION AND I DON'T KNOW HOW 2182 01:39:34,835 --> 01:39:36,737 CLEAR IT IS, THE GENES INVOLVED 2183 01:39:36,804 --> 01:39:38,439 IN THE IMMUNE ACTIVATION WERE 2184 01:39:38,505 --> 01:39:42,976 INDUCED ONE THE INFLUENZA 2185 01:39:43,043 --> 01:39:44,278 INFECTION IN WILD TYPE AND DP16 2186 01:39:44,345 --> 01:39:50,651 AND WHAT IS DIFFERENT IS THE 2187 01:39:50,718 --> 01:39:54,388 MAGNITUDE OF RESPONSE INDUCTION 2188 01:39:54,455 --> 01:39:55,356 OF THE GENE EXPRESSION AND WHEN 2189 01:39:55,422 --> 01:39:57,391 WE LOOKED AT THE PROTEIN LEVEL 2190 01:39:57,458 --> 01:39:58,425 THIS CORRESPONDS BECAUSE FOR 2191 01:39:58,492 --> 01:40:00,894 SOME PROTEINS WE COULD SEE THE 2192 01:40:00,961 --> 01:40:03,030 CHANGE IS HIGH AND IT'S THE 2193 01:40:03,097 --> 01:40:04,865 MAGNITUDE COMPARED TO THE 2194 01:40:04,932 --> 01:40:06,900 NON-INFECTED THAT MAKES A 2195 01:40:06,967 --> 01:40:07,201 DIFFERENCE. 2196 01:40:07,267 --> 01:40:11,705 SOMETIMES YOU HAVE THE CCLs, 2197 01:40:11,772 --> 01:40:14,007 2,3, 4 AND 7 WHICH DON'T GET 2198 01:40:14,074 --> 01:40:16,110 INDUCED TREMENDOUSLY OR AT ALL 2199 01:40:16,176 --> 01:40:20,381 AND WHEREAS THEY HAVE A SEVERE 2200 01:40:20,447 --> 01:40:23,250 INDUCTION AND THEY'RE 2201 01:40:23,317 --> 01:40:24,952 HYPERINFLAMMATORY WHEN THEY GET 2202 01:40:25,018 --> 01:40:25,352 INFECTED. 2203 01:40:25,419 --> 01:40:30,624 WE TRIED TO COMPARE THIS IN 2204 01:40:30,691 --> 01:40:31,625 VIVO. 2205 01:40:31,692 --> 01:40:34,962 THIS IS A COLLABORATION WITH NEW 2206 01:40:35,028 --> 01:40:37,865 YORK MOUNT SINAI AND THEY INFECT 2207 01:40:37,931 --> 01:40:42,002 THE MOUSE THROUGH THE NOSE AND 2208 01:40:42,069 --> 01:40:45,572 DELIVERED THE VIRUS A SUB LETHAL 2209 01:40:45,639 --> 01:40:50,411 OF INFLUENZA INFECTION AND THE 2210 01:40:50,477 --> 01:40:52,646 NUMBER OF INFLAMMATORY CELLS 2211 01:40:52,713 --> 01:40:55,649 MONOCYTES AND NEUTROPHILS HAVE 2212 01:40:55,716 --> 01:40:56,650 MORE IMMUNE CELLS IN THE LUNGS 2213 01:40:56,717 --> 01:41:00,053 AND IF YOU LOOK AT THE PROTEIN 2214 01:41:00,120 --> 01:41:02,790 LEVELS WHAT IS SECRETED INSIDE 2215 01:41:02,856 --> 01:41:04,725 THE BRONCHIAL FLUID AS THE 2216 01:41:04,792 --> 01:41:06,393 HIGHER LEVELS COMPARED TO THE 2217 01:41:06,460 --> 01:41:08,562 WILD TYPE. 2218 01:41:08,629 --> 01:41:12,299 THIS IS INTERESTING AND CAN 2219 01:41:12,366 --> 01:41:22,776 PARTLY EXPLAIN THE HYP 2220 01:41:22,976 --> 01:41:25,846 HYPERINFLAMMATORY TISSUES AND 2221 01:41:25,913 --> 01:41:30,384 ONE WAY TO GO IT MICE IS TO USE 2222 01:41:30,451 --> 01:41:31,919 ISOLATED CELLS OF PEOPLE WITH 2223 01:41:31,985 --> 01:41:32,786 DOWN SYNDROME AND SOMETIMES WE 2224 01:41:32,853 --> 01:41:33,454 CANNOT GET ENOUGH SOURCES OF 2225 01:41:33,520 --> 01:41:34,888 CELLS. 2226 01:41:34,955 --> 01:41:37,191 SO WE BROUGHT IN TECHNOLOGY OF 2227 01:41:37,257 --> 01:41:42,496 ORGAN AND CHIP TECHNOLOGY AND 2228 01:41:42,563 --> 01:41:46,166 THIS IS A TECHNOLOGY THEY'RE 2229 01:41:46,233 --> 01:41:50,804 MORE MACRO FLUIDIC CELL DEVICES 2230 01:41:50,871 --> 01:41:51,872 AND CAN MODEL MORE COMPLEX 2231 01:41:51,939 --> 01:41:54,374 MODELLING OF HUMAN FUNCTIONING 2232 01:41:54,441 --> 01:41:54,942 IN VITRO. 2233 01:41:55,008 --> 01:41:59,780 SO OUR LAB HAS DEVELOPED THREE 2234 01:41:59,847 --> 01:42:01,248 MAJOR ORGAN AND CHIP SYSTEM 2235 01:42:01,315 --> 01:42:02,950 WHICH IS REPRODUCIBLE AND 2236 01:42:03,016 --> 01:42:08,155 RELEVANT TO THE STUDY THE FIRST 2237 01:42:08,222 --> 01:42:10,390 IS WHAT WE CALL LUNG SMALL I'D 2238 01:42:10,457 --> 01:42:15,162 ANDTHE IDEA IS TO HAVE THEM FROM 2239 01:42:15,229 --> 01:42:17,397 HUMAN CELLS AND INTERROGATE THE 2240 01:42:17,464 --> 01:42:18,131 BIOLOGY AND FUNCTION. 2241 01:42:18,198 --> 01:42:25,806 THE SECOND IS A MODEL FOR 2242 01:42:25,873 --> 01:42:27,341 LOOKING AT MACRO VASCULATURE 2243 01:42:27,407 --> 01:42:31,612 THAT ARE IN THE LUMEN AND TRAP 2244 01:42:31,678 --> 01:42:34,781 THE MATRIX AND STROMAL CELLS AND 2245 01:42:34,848 --> 01:42:38,385 STUDY WITH THE STROMAL AND 2246 01:42:38,452 --> 01:42:44,224 ENDOTHELIAL CELLS AND CONTROL 2247 01:42:44,291 --> 01:42:46,994 THE STIFFNESS AND MATRIX AND THE 2248 01:42:47,060 --> 01:42:57,604 THIRD IS TO STUDY HEMATOPOIESIS 2249 01:42:59,373 --> 01:43:02,442 AND SMALL AREAS IN HUMANS ARE 2250 01:43:02,509 --> 01:43:07,180 DEFINED BY A DIAMETER OF 2 2251 01:43:07,247 --> 01:43:10,617 MILLIMETER OR SO AND IT'S A SITE 2252 01:43:10,684 --> 01:43:14,254 OF EXACERBATION FOR PULMONARY 2253 01:43:14,321 --> 01:43:19,293 DISEASE AND GENESIS OF A RANGE 2254 01:43:19,359 --> 01:43:20,394 OF PULMONARY COMPLICATION. 2255 01:43:20,460 --> 01:43:22,296 WE HAVE A MODEL THAT LOOKS LIKE 2256 01:43:22,362 --> 01:43:22,563 THIS. 2257 01:43:22,629 --> 01:43:25,265 IT HAS AN AIR XANL AND HAS A 2258 01:43:25,332 --> 01:43:26,300 BLOOD XANL. 2259 01:43:26,366 --> 01:43:30,437 THE AIR CHANNEL HAS A HEIGHT OF 2260 01:43:30,504 --> 01:43:36,944 1 MILLIMETER THAT'S RADIUS OF A 2261 01:43:37,010 --> 01:43:39,513 SMALL MEMBRANE. 2262 01:43:39,580 --> 01:43:43,216 ON THE TOP WE ADD THE MUCUS 2263 01:43:43,283 --> 01:43:45,352 CELLS AND ON THE BOTTOM WE HAVE 2264 01:43:45,419 --> 01:43:48,622 THE ENDOTHELIAL CELLS AND THEY 2265 01:43:48,689 --> 01:43:51,024 CAN FORM A PACK AND THE DEPTH OF 2266 01:43:51,091 --> 01:43:55,562 THE BLOOD CHANNEL IS 100, TO 200 2267 01:43:55,629 --> 01:44:02,436 MICRON AND YOU CAN MIMIC THE 2268 01:44:02,502 --> 01:44:06,340 POST- 2269 01:44:06,406 --> 01:44:08,642 POST-CAPU LATED CELLS AND THESE 2270 01:44:08,709 --> 01:44:11,378 ARE THE CILIATED CELLS AND THEY 2271 01:44:11,445 --> 01:44:15,015 FORM OTHER SUB TYPES SUCH AS 2272 01:44:15,082 --> 01:44:17,217 MUCUS PRODUCING CELLS AND WE 2273 01:44:17,284 --> 01:44:18,619 HAVE BASAL CELLS AND THE BARRIER 2274 01:44:18,685 --> 01:44:21,321 FUNCTION AND THIS IS WHAT YOU 2275 01:44:21,388 --> 01:44:25,559 SEE THE ENDOTHELIAL CELLS AND 2276 01:44:25,626 --> 01:44:27,594 HAVE CD31 AS WELL AS THE 2277 01:44:27,661 --> 01:44:28,996 MACHINERY AND IMPORTANT FOR 2278 01:44:29,062 --> 01:44:30,430 CAPTURE OF CIRCULATING IMMUNE 2279 01:44:30,497 --> 01:44:36,370 CELLS. 2280 01:44:36,436 --> 01:44:39,539 THE OTHER MODEL IS THE EXTRA 2281 01:44:39,606 --> 01:44:45,078 CELLULAR MATRIX CHIP THAT ALLOWS 2282 01:44:45,145 --> 01:44:49,316 US TO HAVE THE MODEL AND I DON'T 2283 01:44:49,383 --> 01:44:51,151 WANT TO BORE YOU WITH THE DATA 2284 01:44:51,218 --> 01:44:52,619 BUT I WANT TO EMPHASIZE ONE IS A 2285 01:44:52,686 --> 01:44:53,720 LOT OF PEOPLE WHEN THEY ARE WANT 2286 01:44:53,787 --> 01:44:57,190 TO STUDY THE CELLS THEY CALLED 2287 01:44:57,257 --> 01:45:01,128 IT ON THE MICROFLUIDIC SYSTEM OR 2288 01:45:01,194 --> 01:45:04,231 CREATE SQUARE SHAPED OR R 2289 01:45:04,297 --> 01:45:06,133 RECTANGULAR CHANNELS BUT IT'S 2290 01:45:06,199 --> 01:45:07,934 NOT PHYSIOLOGICAL. 2291 01:45:08,001 --> 01:45:11,071 WE HAVE A ROUNDED OVAL SHAPE AND 2292 01:45:11,138 --> 01:45:15,475 THE IMPORTANCE OF THIS IS IF YOU 2293 01:45:15,542 --> 01:45:18,045 DON'T HAVE THE RIGHT SHAPE 2294 01:45:18,111 --> 01:45:20,147 CIRCULAR OR OVAL YOU WON'T HAVE 2295 01:45:20,213 --> 01:45:22,315 A UNIFORM DISTRIBUTION AND 2296 01:45:22,382 --> 01:45:23,750 THAT'S IMPORTANT. 2297 01:45:23,817 --> 01:45:26,420 IN THIS CASE FOR EXAMPLE THE 2298 01:45:26,486 --> 01:45:28,855 RECTANGULAR HAS SQUARE SHAPE AND 2299 01:45:28,922 --> 01:45:34,428 YOU HAVE HUGE ISOLATION OF SHEER 2300 01:45:34,494 --> 01:45:36,530 STRESS SENSING IN THE 2301 01:45:36,596 --> 01:45:36,963 ENDOTHELIAL LEVEL. 2302 01:45:37,030 --> 01:45:38,799 THEY DON'T SEE THE SAME THING 2303 01:45:38,865 --> 01:45:40,934 BUT IN THE SECULAR HAVE YOU MORE 2304 01:45:41,001 --> 01:45:42,102 OR LESS THE SAME SENSING 2305 01:45:42,169 --> 01:45:42,335 THOUGHT. 2306 01:45:42,402 --> 01:45:43,470 THE SECOND THING IS THE LENGTH 2307 01:45:43,537 --> 01:45:46,273 OF THE CHANNEL IS VERY 2308 01:45:46,339 --> 01:45:47,774 IMPORTANT. 2309 01:45:47,841 --> 01:45:50,243 IF SOMEONE SAID WHAT IS THE 2310 01:45:50,310 --> 01:45:54,414 FORMAT AND I HAVE IT EIGHT MI 2311 01:45:54,481 --> 01:45:55,782 MILLIM 2312 01:45:55,849 --> 01:45:56,083 MILLIMETER. 2313 01:45:56,149 --> 01:45:57,451 THERE'S AN AREA FROM THE 2314 01:45:57,517 --> 01:45:58,618 BEGINNING OF THE FLOW COMING TO 2315 01:45:58,685 --> 01:46:02,122 THE CHANNEL UNTIL THE FULLY 2316 01:46:02,189 --> 01:46:03,123 DEVELOPED HERE IS PRESENT AND 2317 01:46:03,190 --> 01:46:04,124 THAT'S CALLED LIKE DEVELOPING 2318 01:46:04,191 --> 01:46:04,691 FLOW. 2319 01:46:04,758 --> 01:46:06,293 IF YOU DON'T CORRECT FOR THAT 2320 01:46:06,359 --> 01:46:09,963 YOU WON'T SEE THE SHEAR STRESS 2321 01:46:10,030 --> 01:46:13,533 AND IF YOU WANT TO SEE THE 2322 01:46:13,600 --> 01:46:15,135 PATHOLOGY IN THE B CELLS OR T 2323 01:46:15,202 --> 01:46:16,369 CELLS IT'S IMPORTANT TO CORRECT 2324 01:46:16,436 --> 01:46:16,837 FOR THAT. 2325 01:46:16,903 --> 01:46:18,305 THE FIRST THING I WANT TO SAY IN 2326 01:46:18,371 --> 01:46:22,175 OUR MODEL WE CAN CONTROL FOR THE 2327 01:46:22,242 --> 01:46:23,477 COMPOSITION OF MATRIX AND 2328 01:46:23,543 --> 01:46:23,744 STIFFNESS. 2329 01:46:23,810 --> 01:46:26,847 WE MIMIC IN THIS CASE BOTH 2330 01:46:26,913 --> 01:46:31,885 NORMAL AND STIFFNESS WHICH IS 2331 01:46:31,952 --> 01:46:38,391 ABOUT 1 TO 2 STIFFNESS AND IN A 2332 01:46:38,458 --> 01:46:46,299 FIBROTIC YOU GROUP TO 30 PILO 2333 01:46:46,366 --> 01:46:52,205 AND WHEN YOU PUT THEM IN THE 2334 01:46:52,272 --> 01:46:53,073 MATRICES YOU DON'T HAVE THE 2335 01:46:53,140 --> 01:46:54,407 NATURAL STIFFNESS YOU HAVE IN 2336 01:46:54,474 --> 01:46:55,008 THE BODY. 2337 01:46:55,075 --> 01:46:57,711 SO THIS IS HOW THE MODEL LOOKS 2338 01:46:57,778 --> 01:46:57,978 LIKE. 2339 01:46:58,044 --> 01:47:02,115 YOU CAN SEE THE ENDOTHELIAL 2340 01:47:02,182 --> 01:47:04,417 CELLS AROUND THE ROUNDED CHANNEL 2341 01:47:04,484 --> 01:47:13,126 AND YOU SEE A MATRIX AND SEE THE 2342 01:47:13,193 --> 01:47:15,695 FIBROBLASTS. 2343 01:47:15,762 --> 01:47:19,332 THEY WANT TO HAVE IT DISPERSE 2344 01:47:19,399 --> 01:47:21,735 THE THROUGHOUT THE MATRIX. 2345 01:47:21,802 --> 01:47:28,275 THE LAST MODEL IS A MODEL FOR 2346 01:47:28,341 --> 01:47:31,711 HEMATOPOIESIS AND WE BRING IT IN 2347 01:47:31,778 --> 01:47:34,014 BEFORE THE CORD BLOOD AND MIX 2348 01:47:34,080 --> 01:47:38,051 THEM WITH THE MESENCHYMAL STEM 2349 01:47:38,118 --> 01:47:43,223 CELLS AND WE CAN DISPERSE THE 2350 01:47:43,290 --> 01:47:44,925 CELLS THREE DIMENSIONALLY AND 2351 01:47:44,991 --> 01:47:51,097 LET THEM DO THE JOB AND THEY 2352 01:47:51,164 --> 01:47:54,301 FORM THE POPULATION AN BECOME 2353 01:47:54,367 --> 01:47:58,038 MYELINATED AND WE CAN STUDY 2354 01:47:58,104 --> 01:47:59,072 LEUKOCYTE EGRESS. 2355 01:47:59,139 --> 01:48:06,012 THIS IS DATA HOW IT LOOKS LIKE 2356 01:48:06,079 --> 01:48:09,549 AS EARLY AS AT SEVEN DAYS AND 2357 01:48:09,616 --> 01:48:14,454 THESE ARE ENDOTHELIAL CELLS AND 2358 01:48:14,521 --> 01:48:18,258 TO SHOW IT COMPARED TO THE OTHER 2359 01:48:18,325 --> 01:48:19,793 CULTURES AND LASTLY IS WHAT 2360 01:48:19,860 --> 01:48:21,228 WE'RE ABLE TO DO. 2361 01:48:21,294 --> 01:48:25,365 WE INTRODUCED IN THE VASCULATURE 2362 01:48:25,432 --> 01:48:30,370 A CHEMOKINE A LIPID MEDIATOR AND 2363 01:48:30,437 --> 01:48:31,938 LOOK AT CELLS AFTER HOW YOU 2364 01:48:32,005 --> 01:48:36,710 WOULD DO IT OTHERWISE IN AN 2365 01:48:36,776 --> 01:48:38,211 IMMUNE CONTEXT AND PUT IN YOUR 2366 01:48:38,278 --> 01:48:40,881 MONOCYTES AND NEUTROPHILS AND 2367 01:48:40,947 --> 01:48:42,415 SEE WHAT DROPS OUT. 2368 01:48:42,482 --> 01:48:43,717 SECOND, YOU GET THE DROPS AND IT 2369 01:48:43,783 --> 01:48:45,418 STAYS THERE AND IN THE BODY 2370 01:48:45,485 --> 01:48:46,653 CELLS ARE PRODUCED AND LIVE. 2371 01:48:46,720 --> 01:48:48,822 IN OUR SYSTEM THEY COME AND GO. 2372 01:48:48,889 --> 01:48:50,957 SO WHAT WE DISCOVERED IS THAT 2373 01:48:51,024 --> 01:48:54,694 THERE'S NO LINEAR RELATION 2374 01:48:54,761 --> 01:49:01,134 BETWEEN THE TYPE OF THE HEMOTAX 2375 01:49:01,201 --> 01:49:04,337 ISIS STARTS AND THE CELLS NEED 2376 01:49:04,404 --> 01:49:07,007 TO BE REPLENISHED. 2377 01:49:07,073 --> 01:49:10,277 NOW, I MENTIONED THIS -- I KNOW 2378 01:49:10,343 --> 01:49:11,912 I'M OUT OF TIME BUT ONE SLIDE I 2379 01:49:11,978 --> 01:49:13,580 WANT TO SHOW IS YOU DEVELOP THIS 2380 01:49:13,647 --> 01:49:16,249 WITHIN A PRIMARY CELLS AND HOW 2381 01:49:16,316 --> 01:49:18,118 TO APPLY THEM WITH THE IPSC 2382 01:49:18,184 --> 01:49:18,385 CELLS. 2383 01:49:18,451 --> 01:49:21,788 THAT'S WHERE WE ARE. 2384 01:49:21,855 --> 01:49:24,090 THIS IS COLLABORATION WITH KELLY 2385 01:49:24,157 --> 01:49:24,391 SULLIVAN. 2386 01:49:24,457 --> 01:49:30,330 WE OBTAIN THE CELLS FROM WILD 2387 01:49:30,397 --> 01:49:33,767 TYPE AND TRISOMIC SUBJECTS AND 2388 01:49:33,833 --> 01:49:34,768 WE'RE ABLE TO PUT THEM HERE. 2389 01:49:34,834 --> 01:49:37,037 YOU CAN SEE THE CROSS SECTION AS 2390 01:49:37,103 --> 01:49:43,877 WE GO THROUGH THE CHANNEL AND 2391 01:49:43,944 --> 01:49:44,678 IT 2392 01:49:44,744 --> 01:49:52,819 IT'S CILIA AND THEY'RE 2393 01:49:52,886 --> 01:49:54,054 MUCOCILIATED CELLS. 2394 01:49:54,120 --> 01:49:56,089 THIS IS SOME OF WHAT I JUST 2395 01:49:56,156 --> 01:49:59,092 MENTIONED AND HOPE IT OPENS UP 2396 01:49:59,159 --> 01:50:03,897 THE PATH FOR ENABLING IT AS A 2397 01:50:03,964 --> 01:50:05,165 CHIP ING AND WITH THE 2398 01:50:05,231 --> 01:50:07,434 MODERNIZATION ACT 2.0 THERE'S 2399 01:50:07,500 --> 01:50:08,201 MORE INTEREST IN THE TECHNOLOGY 2400 01:50:08,268 --> 01:50:11,304 TO ACCELERATE DRUG DEVELOPMENT 2401 01:50:11,371 --> 01:50:14,007 AND TAKING THERAPEUTICS INTO 2402 01:50:14,074 --> 01:50:15,141 CLINIC AND EVEN CLINICAL TRIAL 2403 01:50:15,208 --> 01:50:15,575 IN CHIP. 2404 01:50:15,642 --> 01:50:17,544 WITH THAT I'D LIKE TO THANK YOU 2405 01:50:17,610 --> 01:50:19,112 FOR LISTENING AND THESE ARE OUR 2406 01:50:19,179 --> 01:50:19,646 COLLABORATORS AND FUNDING 2407 01:50:19,713 --> 01:50:19,879 AGENCY. 2408 01:50:19,946 --> 01:50:28,355 THANK YOU. 2409 01:50:28,421 --> 01:50:28,788 >> THANK YOU. 2410 01:50:28,855 --> 01:50:31,057 I'D LIKE TO ASK ALL THE SPEAKER 2411 01:50:31,124 --> 01:50:32,792 TO TAKE A SEAT AT THE TABLE AND 2412 01:50:32,859 --> 01:50:35,195 WHILE THEY DO THAT, IF ANYBODY 2413 01:50:35,261 --> 01:50:36,696 HAS QUESTIONS THERE'S MICS IN 2414 01:50:36,763 --> 01:50:42,669 THE AISLE AND I DO ASK ANYBODY 2415 01:50:42,736 --> 01:50:46,139 WHO ASKS A QUESTION, PLEASE 2416 01:50:46,206 --> 01:50:46,773 IDENTIFY YOURSELF AND ASK YOUR 2417 01:50:46,840 --> 01:50:55,949 QUESTION. 2418 01:50:56,016 --> 01:50:57,650 >> I'M FROM NATIONWIDE 2419 01:50:57,717 --> 01:50:58,685 CHILDREN'S HOSPITAL THANK YOU 2420 01:50:58,752 --> 01:51:00,053 FOR THE TALK. 2421 01:51:00,120 --> 01:51:03,323 A QUESTION FOR DR. LAWRENCE. 2422 01:51:03,390 --> 01:51:06,359 YOU ASKED AXIS TO SILENCE THE 2423 01:51:06,426 --> 01:51:11,297 ADDITIONAL CHROMOSOME 21. 2424 01:51:11,364 --> 01:51:13,733 AND FEMALES ALREADY ACCESS THE 2425 01:51:13,800 --> 01:51:14,200 MECHANISM OVER THERE. 2426 01:51:14,267 --> 01:51:18,705 I GUESS YOUR PAPER YOU USED THE 2427 01:51:18,772 --> 01:51:20,273 MER LINE. 2428 01:51:20,340 --> 01:51:26,413 DO YOU HAVE THOUGHTS ON 2429 01:51:26,479 --> 01:51:31,985 SILENCING CHROMOSOME 21 IN 2430 01:51:32,052 --> 01:51:32,919 FEMALE. 2431 01:51:32,986 --> 01:51:34,754 >> WE'RE CURRENTLY DOING THAT 2432 01:51:34,821 --> 01:51:38,024 RIGHT NOW BUT IT WOULD WORK FINE 2433 01:51:38,091 --> 01:51:40,427 BECAUSE IN NATURAL PEOPLE THERE 2434 01:51:40,493 --> 01:51:43,029 ARE PEOPLE WITH THREE X 2435 01:51:43,096 --> 01:51:45,632 CHROMOSOMES AND MANY DON'T KNOW 2436 01:51:45,698 --> 01:51:47,434 THEY HAVE THREE X CHROMOSOMES. 2437 01:51:47,500 --> 01:51:48,568 THE SYSTEM WOULD NOT BE 2438 01:51:48,635 --> 01:51:49,569 EXCLUSIVE TO MALES. 2439 01:51:49,636 --> 01:51:52,272 WE DID THAT INITIALLY BECAUSE 2440 01:51:52,338 --> 01:51:54,407 IT'S EASIER FOR US TO LOOK AT 2441 01:51:54,474 --> 01:51:56,643 THE RNA AND WHERE IT IS AND NOT 2442 01:51:56,709 --> 01:51:58,778 HAVE TO WORRY ABOUT LOOKING AT 2443 01:51:58,845 --> 01:52:01,214 THE NATURAL X BUT THE SYSTEM 2444 01:52:01,281 --> 01:52:01,915 WORKS EITHER WAY. 2445 01:52:01,981 --> 01:52:10,056 >> THERE'S ALSO A PAPER USING 2446 01:52:10,123 --> 01:52:15,995 CRISPR CAS 9 TO REGENETICALLY -- 2447 01:52:16,062 --> 01:52:17,263 GENETICALLY REMOVE THAT. 2448 01:52:17,330 --> 01:52:19,265 DO YOU HAVE THOUGHTS ON THAT? 2449 01:52:19,332 --> 01:52:20,733 >> I COULD BE AN ALTERNATIVE 2450 01:52:20,800 --> 01:52:24,671 APPROACH BUT I WOULD BE AFRAID 2451 01:52:24,737 --> 01:52:26,005 THE PIECES YOU CUT COULD STICK 2452 01:52:26,072 --> 01:52:28,808 TO OTHER CHROMOSOMES BECAUSE 2453 01:52:28,875 --> 01:52:30,910 WHEN YOU HAVE A TELOMERE BUT I'M 2454 01:52:30,977 --> 01:52:32,645 NOT SURE EXACTLY WHAT'S BEEN 2455 01:52:32,712 --> 01:52:32,846 DONE. 2456 01:52:32,912 --> 01:52:37,684 >> THANK YOU. 2457 01:52:37,750 --> 01:52:47,994 >> A QUESTION OVER HERE. 2458 01:52:48,061 --> 01:52:50,263 >> YOU WERE MENTIONING GENETIC 2459 01:52:50,330 --> 01:52:52,765 BACKGROUND AS BEING A POSSIBLE 2460 01:52:52,832 --> 01:52:53,399 VARIABLE HERE. 2461 01:52:53,466 --> 01:52:58,872 I'M WONDERING IF YOU HAVE MOVED 2462 01:52:58,938 --> 01:53:04,077 YOUR XIST SYSTEM AND IF THE 2463 01:53:04,144 --> 01:53:06,379 PATHWAYS ARE DEPENDENT ON WHAT 2464 01:53:06,446 --> 01:53:06,946 YOU'RE SILENCING IN? 2465 01:53:07,013 --> 01:53:11,818 >> WHAT I SHOWED WAS WE'RE 2466 01:53:11,885 --> 01:53:13,186 SILENCING DIFFERENT CHROMOSOME 2467 01:53:13,253 --> 01:53:15,054 21s IN THE SAME GENETIC 2468 01:53:15,121 --> 01:53:16,422 BACKGROUND WHICH I THINK IS A 2469 01:53:16,489 --> 01:53:17,290 POWERFUL APPROACH. 2470 01:53:17,357 --> 01:53:17,757 >> I AGREE. 2471 01:53:17,824 --> 01:53:20,860 >> WE STARTED DOING THAT. 2472 01:53:20,927 --> 01:53:22,328 WE RECENTLY PUT OUR SYSTEM -- 2473 01:53:22,395 --> 01:53:24,864 WE'RE JUST NOW DOING THE CLONES 2474 01:53:24,931 --> 01:53:26,866 FOR ANOTHER INDIVIDUAL WHO IS A 2475 01:53:26,933 --> 01:53:28,268 FEMALE, BY THE WAY. 2476 01:53:28,334 --> 01:53:31,271 SO PRETTY MUCH EVERYTHING WE'VE 2477 01:53:31,337 --> 01:53:35,208 DONE WAS IN THE BACKGROUND WHICH 2478 01:53:35,275 --> 01:53:36,376 I UNDERSTAND IS A CONSIDERATION. 2479 01:53:36,442 --> 01:53:37,810 BUT WE'RE JUST TRYING TO SEE 2480 01:53:37,877 --> 01:53:39,946 WHAT HAPPENS WHEN YOU MANIPULATE 2481 01:53:40,013 --> 01:53:41,814 21 AND GET RID OF ALL THE 2482 01:53:41,881 --> 01:53:42,048 VESSELS. 2483 01:53:42,115 --> 01:53:46,619 >> YOU CAN'T DO IT ALL. 2484 01:53:46,686 --> 01:53:48,188 >> I WENT PAST MY 2485 01:53:48,254 --> 01:53:50,890 ACKNOWLEDGEMENT SLIDE. 2486 01:53:50,957 --> 01:53:55,161 I WANT TO THANK ERIC LARSON AND 2487 01:53:55,228 --> 01:53:56,563 MY COLLABORATOR IN THE MOUSE AND 2488 01:53:56,629 --> 01:53:58,831 I WANT TO THANK NIGMS. 2489 01:53:58,898 --> 01:54:05,805 SORRY, NICHD. 2490 01:54:05,872 --> 01:54:07,173 >> I'M FROM TEXAS UNIVERSITY. 2491 01:54:07,240 --> 01:54:09,676 I HAVE A QUESTION ABOUT THE 2492 01:54:09,742 --> 01:54:10,510 TRISOMIC RATS. 2493 01:54:10,577 --> 01:54:14,781 I THINK IT'S A NICE EXTENSION OF 2494 01:54:14,847 --> 01:54:16,416 OUR INFORMATION AND CURIOUS IF 2495 01:54:16,482 --> 01:54:20,920 YOU IDENTIFIED ANY CRANIOFACIAL 2496 01:54:20,987 --> 01:54:22,422 ABNORMALITIES OR TOOTH ERUPTION 2497 01:54:22,488 --> 01:54:23,223 ISSUES OR ANY OTHER PHENOTYPIC 2498 01:54:23,289 --> 01:54:26,859 DIFFERENCES? 2499 01:54:26,926 --> 01:54:29,562 >> THANKS NOR QUESTION. 2500 01:54:29,629 --> 01:54:30,430 -- FOR THE QUESTION. 2501 01:54:30,496 --> 01:54:32,832 IN TERMS OF ONE OF THE RATS 2502 01:54:32,899 --> 01:54:39,439 WE'VE MADE, ONE IS AN ARNO 20 2503 01:54:39,505 --> 01:54:41,808 AND THE OTHER IS 11. 2504 01:54:41,874 --> 01:54:43,776 THERE'S NO CRANIAL DIFFERENCES 2505 01:54:43,843 --> 01:54:49,449 AT 50 BONY LANDMARKS, HOWEVER, 2506 01:54:49,515 --> 01:54:52,218 IN THE ARNO 20 RATS THEY'RE 2507 01:54:52,285 --> 01:54:53,052 READILY APPARENT COGNITIVE 2508 01:54:53,119 --> 01:54:56,723 DIFFERENCES AND DO ALL THE MAZES 2509 01:54:56,789 --> 01:54:57,156 DIFFERENCE. 2510 01:54:57,223 --> 01:54:58,458 WHILE THERE'S NO STRUCTURAL 2511 01:54:58,524 --> 01:55:02,996 DIFFERENCE IN CRANIAL OR TEETH 2512 01:55:03,062 --> 01:55:04,397 ARE DIFFERENT. 2513 01:55:04,464 --> 01:55:08,134 >> HAVE YOU DONE MRI OR DONE AN 2514 01:55:08,201 --> 01:55:10,937 CT OF THE SPINE OR LONG BONES? 2515 01:55:11,004 --> 01:55:12,939 >> HAVE NOT. 2516 01:55:13,006 --> 01:55:15,375 THANK YOU FOR THE QUESTION. 2517 01:55:15,441 --> 01:55:20,880 >> LARRY BASER, NATIONAL HEART, 2518 01:55:20,947 --> 01:55:22,048 LUNG AND BLOOD INSTITUTE. 2519 01:55:22,115 --> 01:55:24,651 IN PEOPLE WITH COVID IS THERE AN 2520 01:55:24,717 --> 01:55:25,885 AREA OF ACTIVE INVESTIGATION? 2521 01:55:25,952 --> 01:55:29,289 YOU SHOWED AND WE KNOW THE ACUTE 2522 01:55:29,355 --> 01:55:30,456 EFFECTS ARE MORE PROFOUND AND 2523 01:55:30,523 --> 01:55:32,859 MORE FATAL IN PEOPLE WITH DOWN 2524 01:55:32,925 --> 01:55:33,559 SYNDROME. 2525 01:55:33,626 --> 01:55:36,529 I'M WONDERING ABOUT THE 2526 01:55:36,596 --> 01:55:37,830 LONG-TERM EFFECT OF PEOPLE WITH 2527 01:55:37,897 --> 01:55:38,031 THAT. 2528 01:55:38,097 --> 01:55:39,098 DO YOU KNOW? 2529 01:55:39,165 --> 01:55:40,099 >> DON'T KNOW. 2530 01:55:40,166 --> 01:55:41,234 GREAT QUESTION. 2531 01:55:41,301 --> 01:55:43,936 THERE'S IN THE LITERATURE SOME 2532 01:55:44,003 --> 01:55:45,071 DOUBT IN SOME PEOPLE'S MIND 2533 01:55:45,138 --> 01:55:45,938 THERE'S A LONG COVID. 2534 01:55:46,005 --> 01:55:50,777 >> I THINK WE KNOW THERE IS. 2535 01:55:50,843 --> 01:55:53,313 >> WE CAN TALK AFTER. 2536 01:55:53,379 --> 01:55:58,418 THERE'S PLENTY OF DEBATE THAT 2537 01:55:58,484 --> 01:56:04,590 SUGGESTS THE SEQUELAE ARE 2538 01:56:04,657 --> 01:56:07,994 RELATED TO COVID BUT I'M NOT 2539 01:56:08,061 --> 01:56:12,365 FAMILIAR WITH ANY SPECIFIC DATA 2540 01:56:12,432 --> 01:56:13,333 ABOUT LONG-TERM EFFECTS. 2541 01:56:13,399 --> 01:56:17,203 >> DOWN SYNDROME PEOPLE HAVE 2542 01:56:17,270 --> 01:56:21,641 INCREASED SUSCEPTIBILITY TO 2543 01:56:21,708 --> 01:56:23,176 CARDIO AND PULMONARY EFFECT. 2544 01:56:23,242 --> 01:56:24,877 >> AS FAR AS I KNOW, NO. 2545 01:56:24,944 --> 01:56:25,611 >> THANKS. 2546 01:56:25,678 --> 01:56:36,155 >> BEFORE I DO MY QUESTION, 2547 01:56:38,524 --> 01:56:39,258 JOAQUIN HE ESPINOZA COLORADO. 2548 01:56:39,325 --> 01:56:43,830 AND THERE WAS A REPORT OF A 2549 01:56:43,896 --> 01:56:49,502 DOCTOR WHO CARES FOR ADULTS WITH 2550 01:56:49,569 --> 01:56:54,407 DOWN SYNDROME AND LONG-TERM 2551 01:56:54,474 --> 01:56:57,477 SEQUELAE AND RELATED QUESTION, 2552 01:56:57,543 --> 01:56:59,879 SO FIRST OF ALL, YOU'RE RIGHT, 2553 01:56:59,946 --> 01:57:01,180 WE SHOULD HAVE LUNG INFECTIONS 2554 01:57:01,247 --> 01:57:09,989 OF THE TOP OF EVERY SLIDE AND 2555 01:57:10,056 --> 01:57:11,657 ALZHEIMER'S AND OTHERS THINGS 2556 01:57:11,724 --> 01:57:12,625 ARE RIGHT. 2557 01:57:12,692 --> 01:57:14,827 PEOPLE WITH DOWN SYNDROME ARE 2558 01:57:14,894 --> 01:57:25,438 DYING AT A DISPROPORTIONATE RATE 2559 01:57:25,872 --> 01:57:27,874 OF PEOPLE WITH DOWN SYNDROME AND 2560 01:57:27,940 --> 01:57:30,877 THE IMMUNE RESPONSE IS GOING 2561 01:57:30,943 --> 01:57:32,011 BANANAS. 2562 01:57:32,078 --> 01:57:34,747 THE GRAPHS YOU WERE SHOWING 2563 01:57:34,814 --> 01:57:41,954 THREE AND THREE FOUR TIMES 2564 01:57:42,021 --> 01:57:42,455 KRAOF 2565 01:57:42,522 --> 01:57:43,956 GREATER CYTOKINES. 2566 01:57:44,023 --> 01:57:51,464 IS THAT HOW WE PROTECT ADULTS BY 2567 01:57:51,531 --> 01:57:54,634 TONING DOWN THE CYTOKINE STORM 2568 01:57:54,700 --> 01:57:58,004 ARE YOU SEEING THAT AS A 2569 01:57:58,070 --> 01:57:58,504 THERAPEUTIC OPPORTUNITY? 2570 01:57:58,571 --> 01:58:00,740 >> IT CAN BE A PATH TO 2571 01:58:00,807 --> 01:58:01,574 DEVELOPING THERAPEUTIC. 2572 01:58:01,641 --> 01:58:05,278 ONE AREA WE HAVE NOT EXPLORED OF 2573 01:58:05,344 --> 01:58:10,616 SECRETION OF INNATE 2574 01:58:10,683 --> 01:58:12,585 ANTIMICROBIAL DIVERSE OF MUCOSA. 2575 01:58:12,652 --> 01:58:15,288 ANY SORT OF PROTEINS THAT ARE 2576 01:58:15,354 --> 01:58:17,390 SECRETED CAN ADHERE TO THE VIRUS 2577 01:58:17,457 --> 01:58:20,092 BEFORE THEY EVEN SIMULATE THE 2578 01:58:20,159 --> 01:58:20,960 CELLS TO CAUSE IMMUNE 2579 01:58:21,027 --> 01:58:21,260 ACTIVATION. 2580 01:58:21,327 --> 01:58:23,663 HAVE THEY CHANGED OR NOT? 2581 01:58:23,729 --> 01:58:26,365 THAT COULD POTENTIALLY BE ONE 2582 01:58:26,432 --> 01:58:26,632 PATH. 2583 01:58:26,699 --> 01:58:28,568 IF I PUT MY BET BASED ON THE 2584 01:58:28,634 --> 01:58:31,637 CURRENT DATA I WOULD SAY THEY'RE 2585 01:58:31,704 --> 01:58:33,639 TARGETING THE IMMUNE PATH IS 2586 01:58:33,706 --> 01:58:37,343 LIKELY FRUITFUL IN AMELIORATING 2587 01:58:37,410 --> 01:58:39,011 THE SYMPTOMS. 2588 01:58:39,078 --> 01:58:40,279 >> THANK YOU. 2589 01:58:40,346 --> 01:58:44,684 >> WE HAVE ONE FOR ONE MORE 2590 01:58:44,750 --> 01:58:45,585 BRIEF QUESTION. 2591 01:58:45,651 --> 01:58:47,854 >> ARE YOU GUYS GOING TO WORK 2592 01:58:47,920 --> 01:58:49,956 TOGETHER TO DO PRIMARY, 2593 01:58:50,022 --> 01:58:50,957 SECONDARY INFECTION MODELS? 2594 01:58:51,023 --> 01:58:53,993 >> I DON'T KNOW IF WE'LL WORK 2595 01:58:54,060 --> 01:58:55,528 TOGETHER ON THAT BUT WE'RE 2596 01:58:55,595 --> 01:58:58,531 WORKING SEPARATELY TO DO THAT. 2597 01:58:58,598 --> 01:59:00,399 >> GREAT, I'LL ASK YOU LONG 2598 01:59:00,466 --> 01:59:00,900 QUESTIONS LATER. 2599 01:59:00,967 --> 01:59:04,036 >> I JUST WANT TO MENTION THAT 2600 01:59:04,103 --> 01:59:07,940 WE STARTED TO DO A TEST WHETHER 2601 01:59:08,007 --> 01:59:10,610 VIRAL SUSCEPTIBLE WAS DONE WITH 2602 01:59:10,676 --> 01:59:11,777 SILENCING THE CHROMOSOME 21 AND 2603 01:59:11,844 --> 01:59:15,014 WERE WORKING WITH ROBERT 2604 01:59:15,081 --> 01:59:17,283 FINCHBERG WHO UNFORTUNATELY DIED 2605 01:59:17,350 --> 01:59:19,285 DURING THE WORK BUT THE 2606 01:59:19,352 --> 01:59:20,286 PRELIMINARILY RESEARCH SHOWED 2607 01:59:20,353 --> 01:59:24,790 THE VIRUS DID REPLICATE MORE 2608 01:59:24,857 --> 01:59:25,958 WITHOUT SILENCING SO THERE MAY 2609 01:59:26,025 --> 01:59:26,926 BE DIRECT EFFECT. 2610 01:59:26,993 --> 01:59:28,227 >> JOIN ME IN THANKING THE 2611 01:59:28,294 --> 01:59:28,561 SPEAKERS. 2612 01:59:34,333 --> 01:59:36,335 WE'LL NOW TAKE A SHORT BREAK AND 2613 01:59:36,402 --> 01:59:39,872 WE'LL START AGAIN AT 10:45. 2614 01:59:39,939 --> 01:59:41,741 FOR THOSE MEMBERS OF THE PANEL 2615 01:59:41,807 --> 01:59:44,277 WHO WILL BE JOINING ME ON THE 2616 01:59:44,343 --> 01:59:48,848 STAGE AT 10:45, IF YOU CAN COME 2617 01:59:48,915 --> 01:59:49,949 TO THE FRONT AS EARLY AS AS 2618 01:59:50,016 --> 01:59:50,216 POSSIBLE. 2619 01:59:50,283 --> 01:59:51,784 MANY THANKS. 2620 01:59:51,851 --> 01:59:53,553 >> WE'RE READY TO START OUR 2621 01:59:53,619 --> 01:59:54,587 FIRST PANEL OF THE MEETING 2622 01:59:54,654 --> 01:59:58,090 FOCUSSED ON BASIC AND 2623 01:59:58,157 --> 01:59:58,824 TRANSLATIONAL RESEARCH SCIENCE. 2624 01:59:58,891 --> 02:00:01,527 SO THE STRUCTURE OF THESE PANELS 2625 02:00:01,594 --> 02:00:08,467 IS AS YOU SEE WE HAVE A NUMBER 2626 02:00:08,534 --> 02:00:09,669 OF OUR COLLEAGUES JOINED ME AT 2627 02:00:09,735 --> 02:00:11,337 THE TABLE. 2628 02:00:11,404 --> 02:00:12,738 EACH WILL GIVE A SHORT 2629 02:00:12,805 --> 02:00:14,607 PRESENTATION AND THEN WE'LL HAVE 2630 02:00:14,674 --> 02:00:22,415 THE REMAINDER OF OUR HOUR TO 2631 02:00:22,481 --> 02:00:24,850 TAKE QUESTION. 2632 02:00:24,917 --> 02:00:26,619 WE WOULD LIKE TO SEE THIS BE 2633 02:00:26,686 --> 02:00:30,590 MORE OF A DISCUSSION PLATFORM. 2634 02:00:30,656 --> 02:00:34,360 A DISCUSSION SESSION. 2635 02:00:34,427 --> 02:00:40,232 WITH A FOCUS ON IDENTIFYING THE 2636 02:00:40,299 --> 02:00:47,173 CHALLENGES OF USING MODEL 2637 02:00:47,239 --> 02:00:48,908 SYSTEMS FOR BASIC RESEARCH AND 2638 02:00:48,975 --> 02:00:50,576 POSSIBLE SOLUTION. 2639 02:00:50,643 --> 02:00:51,210 OUR FIRST SPEAKER IS RANDAL 2640 02:00:51,277 --> 02:01:01,387 ROPER. 2641 02:01:22,274 --> 02:01:26,579 >> WHEN WE TALK ABOUT MOUSE 2642 02:01:26,646 --> 02:01:30,583 MODEL OR ANY MODEL WE WANT TO 2643 02:01:30,650 --> 02:01:32,251 UNDERSTAND HOW DOES THE MODEL 2644 02:01:32,318 --> 02:01:33,452 RECAPITULATE THE CONSTRUCT OR 2645 02:01:33,519 --> 02:01:36,689 THE GENETICS WE MIGHT SAY? 2646 02:01:36,756 --> 02:01:40,660 THE NEXT IS THE FACE OR HOW WELL 2647 02:01:40,726 --> 02:01:44,830 THE MODEL MIMICS THE MEC LAR OR 2648 02:01:44,897 --> 02:01:46,065 PHENOTYPES WE SEE IN THE MODEL 2649 02:01:46,132 --> 02:01:48,934 AND THE THIRD THING WE WANT ASK 2650 02:01:49,001 --> 02:01:51,470 ABOUT IS WHAT IS THE PREDICTIVE 2651 02:01:51,537 --> 02:01:52,638 VALUE OF THE MODEL AND HOW WILL 2652 02:01:52,705 --> 02:01:54,206 THE MODEL HELP US PREDICT WHAT 2653 02:01:54,273 --> 02:01:58,878 WE MIGHT FIND IN HUMANS? 2654 02:01:58,944 --> 02:02:01,013 SO THERE'S A NUMBER OF DIFFERENT 2655 02:02:01,080 --> 02:02:03,082 MOUSE MODELS OF DIFFERENT 2656 02:02:03,149 --> 02:02:05,017 SYNDROME AND WE HAVE MOUSE 2657 02:02:05,084 --> 02:02:11,957 MODELS WITH A SEGMENTAL TRISOMIC 2658 02:02:12,024 --> 02:02:15,795 AND TRANS CHROMOSOMIC AND GENE 2659 02:02:15,861 --> 02:02:19,065 MODELS AND I LISTED THEM DOWN 2660 02:02:19,131 --> 02:02:19,331 BELOW. 2661 02:02:19,398 --> 02:02:23,202 THIS IS A SCHEMATIC OF HUMAN 2662 02:02:23,269 --> 02:02:25,971 CHROMOSOME 21. 2663 02:02:26,038 --> 02:02:30,576 WE HAVE TWO TRANS CHROMOSOMIC 2664 02:02:30,643 --> 02:02:32,411 MOLDS AND MANY ARE REPRESENTED 2665 02:02:32,478 --> 02:02:37,850 ON THREE MICE CHROMOSOMES AND A 2666 02:02:37,917 --> 02:02:40,686 NUMBER WHICH ARE DUPLICATION 2667 02:02:40,753 --> 02:02:40,953 MODELS. 2668 02:02:41,020 --> 02:02:42,254 WE'RE FORTUNATE IN DOWN SYNDROME 2669 02:02:42,321 --> 02:02:49,762 TO HAVE A PLETHORA OF SO MANY 2670 02:02:49,829 --> 02:02:50,262 MODE 2671 02:02:50,329 --> 02:02:55,501 MODELS E SPECIALLY MOUSE MODELS 2672 02:02:55,568 --> 02:02:56,769 WITH ZEBRAFISH OR CELL LINES. 2673 02:02:56,836 --> 02:02:59,438 IF YOU'RE ABLE TO ATTEND THE 2674 02:02:59,505 --> 02:03:01,874 T21RS MEETING WE HAVE A SESSION 2675 02:03:01,941 --> 02:03:03,008 DEVOTED TO THE OTHER MOUSE 2676 02:03:03,075 --> 02:03:03,209 MOLDS. 2677 02:03:03,275 --> 02:03:05,711 I OFTEN GET THE QUESTION, WHICH 2678 02:03:05,778 --> 02:03:06,612 MOUSE MODEL IS THE BEST ONE? 2679 02:03:06,679 --> 02:03:11,851 I HAVE THE ANSWER. 2680 02:03:11,917 --> 02:03:14,653 IT DEPENDS. 2681 02:03:14,720 --> 02:03:16,088 WHAT DOES IT DEPEND ON? 2682 02:03:16,155 --> 02:03:18,624 WELL, WE'RE GOING TALK ABOUT A 2683 02:03:18,691 --> 02:03:19,358 NUMBER THESE THINGS. 2684 02:03:19,425 --> 02:03:20,893 YOU KNOW, YOU WANT TO LOOK AT 2685 02:03:20,960 --> 02:03:22,661 WHAT OTHERS HAVE DONE AND WHAT 2686 02:03:22,728 --> 02:03:25,231 OTHERS ARE USED AND YOU WANT TO 2687 02:03:25,297 --> 02:03:27,466 SEE WHAT THE LITERATURE SAYS 2688 02:03:27,533 --> 02:03:28,734 ABOUT THE DIFFERENT MOUSE 2689 02:03:28,801 --> 02:03:28,968 MODELS. 2690 02:03:29,034 --> 02:03:30,436 IF THERE'S NEW ONES AND WHAT ARE 2691 02:03:30,503 --> 02:03:34,006 THE IMPROVEMENTS AND IF YOU LOOK 2692 02:03:34,073 --> 02:03:35,708 AT THE PHENOTYPE IF THERE'S NO 2693 02:03:35,775 --> 02:03:36,809 INFORMATION I WOULD ENCOURAGE 2694 02:03:36,876 --> 02:03:39,278 THAT YOU USE AT LEAST TWO 2695 02:03:39,345 --> 02:03:40,412 DIFFERENT DOWN SYNDROME MOUSE 2696 02:03:40,479 --> 02:03:40,813 MODELS. 2697 02:03:40,880 --> 02:03:42,414 SO YOU NEED TO KNOW YOUR MOUSE 2698 02:03:42,481 --> 02:03:48,354 AND NEED TO KNOW THINGS LIKE THE 2699 02:03:48,420 --> 02:03:50,089 GENETIC CONTENT, WHAT ARE GENES 2700 02:03:50,156 --> 02:03:53,893 ARE COPIED AND WHAT OTHER 2701 02:03:53,959 --> 02:03:54,660 INFORMATION INHERITED AND SOME 2702 02:03:54,727 --> 02:03:57,596 ARE NOT HOMOLOGOUS TO CHROMOSOME 2703 02:03:57,663 --> 02:03:57,763 21. 2704 02:03:57,830 --> 02:04:03,836 DOES IT HAVE PHENOTYPES YOU 2705 02:04:03,903 --> 02:04:05,437 EXPECT AND WHAT ARE THE 2706 02:04:05,504 --> 02:04:05,738 DIFFERENCES? 2707 02:04:05,805 --> 02:04:08,741 PART OF MY LAB STUDY PHENOTYPES 2708 02:04:08,808 --> 02:04:12,678 ASSOCIATED WITH DOWN SYNDROME. 2709 02:04:12,745 --> 02:04:17,783 SEE A FEMUR MUCH A MOUSE AND AT 2710 02:04:17,850 --> 02:04:28,394 THE DISTAL END THE TRABECULAR 2711 02:04:43,676 --> 02:04:50,382 BONE AND THE TRIPLICATED MOUSE 2712 02:04:50,449 --> 02:04:54,353 AND HAVE YOU THE GRAY LINES ARE 2713 02:04:54,420 --> 02:05:04,964 GREATER THAN UPLOID AND YOU SEE 2714 02:05:08,567 --> 02:05:13,672 THAT IN CORTIC CAL BONE MALES 2715 02:05:13,739 --> 02:05:14,673 AND FEMALES HAVE THE SAME 2716 02:05:14,740 --> 02:05:23,949 CORTICAL BONE. 2717 02:05:24,016 --> 02:05:25,951 WE GET SEX DIFFERENCE AND 2718 02:05:26,018 --> 02:05:32,625 THERE'S THE TS69 AND DP16 THIS 2719 02:05:32,691 --> 02:05:35,294 THE TRABECULAR BONE. 2720 02:05:35,361 --> 02:05:38,464 WE SEE MALES HAVE REDUCED 2721 02:05:38,530 --> 02:05:43,836 TRABECULAR BONES AND TRISOMIC 2722 02:05:43,903 --> 02:05:46,472 MICE DO AND FEMALES DON'T BUT IN 2723 02:05:46,538 --> 02:05:51,944 THE CORTICAL BONE WE SEE A 2724 02:05:52,011 --> 02:06:02,554 DIFFERENCE WE SEE A REDUCTION ON 2725 02:06:08,560 --> 02:06:09,161 THE STRAINS. 2726 02:06:09,228 --> 02:06:12,131 THE LAST POINT I'D LIKE TO MAKE 2727 02:06:12,197 --> 02:06:13,265 IS A LITTLE BIT ABOUT SEX 2728 02:06:13,332 --> 02:06:13,565 DIFFERENCES. 2729 02:06:13,632 --> 02:06:14,700 WE JUST PUBLISHED THE DATA. 2730 02:06:14,767 --> 02:06:17,136 WHAT WE SEE HERE IS WE'RE 2731 02:06:17,202 --> 02:06:18,604 LOOKING AT DIRK 1A EXPRESSION. 2732 02:06:18,671 --> 02:06:24,410 THIS IS PROTEIN EXPRESSION AND 2733 02:06:24,476 --> 02:06:29,748 WE'RE LOOKING AT POST NATAL DAY 2734 02:06:29,815 --> 02:06:31,750 SIX AND THE DIRK 1A EXPRESSION 2735 02:06:31,817 --> 02:06:34,053 IS UPREGULATED IN THE 2736 02:06:34,119 --> 02:06:39,091 HIPPOCAMPUS AND CEREBRAL CORTEX 2737 02:06:39,158 --> 02:06:44,029 AND CEREBELLUM AND IN P15 IT'S 2738 02:06:44,096 --> 02:06:45,864 UPREGULATED IN MALES BUT NOT 2739 02:06:45,931 --> 02:06:47,199 FEMALES AND FROM CONCEPTION WE 2740 02:06:47,266 --> 02:06:51,570 SEE IT'S LOWERED AT P6 MALES AND 2741 02:06:51,637 --> 02:06:54,106 FEMALES BUT IN OUR FEMALES WHERE 2742 02:06:54,173 --> 02:06:56,241 DIDN'T SEE UP REGULATION WE CAN 2743 02:06:56,308 --> 02:07:01,513 KNOCK DOWN ONE COPY OF DYRK1A 2744 02:07:01,580 --> 02:07:01,814 EXPRESSION. 2745 02:07:01,880 --> 02:07:03,916 VERY IMPORTANT TO LOOK AT WHAT'S 2746 02:07:03,983 --> 02:07:06,051 GOING ON IN MALES AND FEMALES. 2747 02:07:06,118 --> 02:07:07,519 IN WORKING WITH MOUSE MODELS WE 2748 02:07:07,586 --> 02:07:09,355 HAVE TO UNDERSTAND THE 2749 02:07:09,421 --> 02:07:10,322 DIFFERENCES BETWEEN MOUSE 2750 02:07:10,389 --> 02:07:10,556 MODELS. 2751 02:07:10,622 --> 02:07:12,124 WE WANT TO USE THE BEST MODEL 2752 02:07:12,191 --> 02:07:17,863 FOR GENETIC AND PHENOTYPIC 2753 02:07:17,930 --> 02:07:18,664 HYPOTHESIS THAT HOPEFULLY 2754 02:07:18,731 --> 02:07:19,865 PREDICT WHAT'S GOING ON IN 2755 02:07:19,932 --> 02:07:20,099 HUMANS. 2756 02:07:20,165 --> 02:07:22,167 IT'S BEST TO USE TWO OR MORE 2757 02:07:22,234 --> 02:07:23,669 MOUSE MODELS IN EVALUATING 2758 02:07:23,736 --> 02:07:25,270 DIFFERENCES BETWEEN THE SEXES. 2759 02:07:25,337 --> 02:07:29,508 THIS WORK WAS DONE WITH THE LAB, 2760 02:07:29,575 --> 02:07:35,647 LONG TIME COLLABORATOR CHARLIE 2761 02:07:35,714 --> 02:07:38,250 GOLET AND I HOPE YOU'LL VISIT 2762 02:07:38,317 --> 02:07:40,619 THEIR POSTERS TO TALK WITH THEIR 2763 02:07:40,686 --> 02:07:41,186 WORK. 2764 02:07:41,253 --> 02:07:42,621 THANK YOU AND I THINK WE'LL GO 2765 02:07:42,688 --> 02:07:43,222 TO THE NEXT PRESENTATION FROM 2766 02:07:43,288 --> 02:07:51,430 THERE. 2767 02:07:51,497 --> 02:07:55,067 >> OUR NEXT PRESENTER IS TIFFANY 2768 02:07:55,134 --> 02:08:05,244 GLASS. 2769 02:08:09,915 --> 02:08:10,883 >> THANKS FOR THE OPPORTUNITY TO 2770 02:08:10,949 --> 02:08:12,885 SHARE THOUGHTS TODAY. 2771 02:08:12,951 --> 02:08:16,889 I'M FROM THE UNIVERSITY OF 2772 02:08:16,955 --> 02:08:17,723 WISCONSIN-MADISON IN THE 2773 02:08:17,790 --> 02:08:22,594 DEPARTMENT OF SURGERY, 2774 02:08:22,661 --> 02:08:29,968 DEPARTMENT OF LARYNGOLOGY. 2775 02:08:30,035 --> 02:08:32,504 I'LL GIVE A QUICK INTRODUCTION 2776 02:08:32,571 --> 02:08:33,672 TO THE PREMISES BEHIND SOME OF 2777 02:08:33,739 --> 02:08:38,210 THE AND SHOW A FEW EXAMPLES MUCH 2778 02:08:38,277 --> 02:08:40,913 THE TYPES OF DATA SETS WE USE 2779 02:08:40,979 --> 02:08:43,048 USING THE EXPERIMENTAL PARADIGMS 2780 02:08:43,115 --> 02:08:46,151 AND SHARE THOUGHTS ON AREAS TO 2781 02:08:46,218 --> 02:08:47,719 TRANSLATING BASIC RESEARCH TO 2782 02:08:47,786 --> 02:08:48,420 BENEFIT PEOPLE WITH DOWN 2783 02:08:48,487 --> 02:08:48,887 SYNDROME. 2784 02:08:48,954 --> 02:08:52,724 FOR SOME INDIVIDUALS, DOWN 2785 02:08:52,791 --> 02:08:56,228 SYNDROME CAN ENTAIL DIFFICULTIES 2786 02:08:56,295 --> 02:08:58,597 IN FEEDING AND SWALLOWING AND 2787 02:08:58,664 --> 02:09:00,532 CAN MANIFEST IN DIFFERENT WAYS 2788 02:09:00,599 --> 02:09:02,267 DELVE DEPENDING ON THE 2789 02:09:02,334 --> 02:09:08,640 DEVELOPMENT STAGE. 2790 02:09:08,707 --> 02:09:09,408 DYSPHASIA WILL LOOK DIFFERENT 2791 02:09:09,475 --> 02:09:12,711 FROM EATING AND DRINKING IN 2792 02:09:12,778 --> 02:09:14,213 SWALLOWING AT OTHER OLDER 2793 02:09:14,279 --> 02:09:15,614 RELATED TO COMORBIDITIES RELATED 2794 02:09:15,681 --> 02:09:17,149 TO AGING. 2795 02:09:17,216 --> 02:09:19,585 WE KNOW THE CHALLENGING WITH 2796 02:09:19,651 --> 02:09:22,721 EATING, DRINK AND SWALLOWING CAN 2797 02:09:22,788 --> 02:09:25,124 INVOLVE A WIDE VARIETY OF 2798 02:09:25,190 --> 02:09:25,557 COMORBIDITY. 2799 02:09:25,624 --> 02:09:26,592 CONSIDERING DIFFERENCE IN 2800 02:09:26,658 --> 02:09:28,861 DEVELOPMENT OR LIFE STAGE AND 2801 02:09:28,927 --> 02:09:30,529 THE VARIETY OF CO-MORBIDITY. 2802 02:09:30,596 --> 02:09:31,997 THESEERS CAN CAN LOOK VERY 2803 02:09:32,064 --> 02:09:33,265 DIFFERENT BETWEEN DIFFERENT 2804 02:09:33,332 --> 02:09:42,741 INDIVIDUALS WITH DOWN SYNDROME. 2805 02:09:42,808 --> 02:09:46,478 TO THE SWALLOWING IS IMPORTANT 2806 02:09:46,545 --> 02:09:50,616 AND WE STUDY THE TONGUE MUSCLE 2807 02:09:50,682 --> 02:09:54,586 SYSTEM AND WE LOOK AT LARGE HIGH 2808 02:09:54,653 --> 02:09:56,555 RESOLUTION MICROSCOPY OF TONGUE 2809 02:09:56,622 --> 02:10:00,526 TISSUE SECTION FROM THE DN MOUSE 2810 02:10:00,592 --> 02:10:02,127 MODEL OF DOWN SYNDROME AND CAN 2811 02:10:02,194 --> 02:10:03,996 STAIN THE SECTION FOR DIFFERENT 2812 02:10:04,062 --> 02:10:06,498 MARKERS OF TONGUE MUSCLE BIOLOGY 2813 02:10:06,565 --> 02:10:10,602 AND THIS LETS US ANALYZE EIGHT 2814 02:10:10,669 --> 02:10:14,039 OF DIFFERENCES IN TONGUE MUSCLE 2815 02:10:14,106 --> 02:10:16,508 MYOFIBERS AND CAN STUDY 2816 02:10:16,575 --> 02:10:20,445 MICROANATOMICAL STRUCTURE AND WE 2817 02:10:20,512 --> 02:10:28,854 USE A PARADIGM TO STUDY TONGUE, 2818 02:10:28,921 --> 02:10:29,855 MUSCLE PHYSIOLOGY AND WE FOUND 2819 02:10:29,922 --> 02:10:35,661 IT DEMONSTRATES EARLY ONSET OF 2820 02:10:35,727 --> 02:10:41,400 TONGUE MUSCLE FATIGUE AND U 2821 02:10:41,466 --> 02:10:44,036 EUPLOID CONTROLS AND WE QUANTIFY 2822 02:10:44,102 --> 02:10:46,038 AND EVALUATE SWALLOWING 2823 02:10:46,104 --> 02:10:48,774 FUNCTIONS OF MOUSE MODELS AND 2824 02:10:48,840 --> 02:10:52,311 VIDEO FLUOROSCOPY IS CONSIDERED 2825 02:10:52,377 --> 02:10:54,580 ONE GOLD STANDARD METHOD TO 2826 02:10:54,646 --> 02:10:55,380 EVALUATE SWALLOWING FUNCTIONING 2827 02:10:55,447 --> 02:10:57,316 IN HUMANS AND HAVE BEEN ABLE TO 2828 02:10:57,382 --> 02:11:00,118 ADAPT THEM TO QUANTIFY ASPECTS 2829 02:11:00,185 --> 02:11:01,086 OF SWALLOWING FUNCTION IN THE 2830 02:11:01,153 --> 02:11:01,520 MOUSE MODEL. 2831 02:11:01,587 --> 02:11:05,991 AS WE CONTINUE TO WORK ON THE 2832 02:11:06,058 --> 02:11:08,393 STUDIES WE STARTED TO 2833 02:11:08,460 --> 02:11:10,062 DEMONSTRATE WAYS TO SHARE THE 2834 02:11:10,128 --> 02:11:11,063 DATA SETS WITH THE RESEARCH 2835 02:11:11,129 --> 02:11:11,363 COMMUNITY. 2836 02:11:11,430 --> 02:11:14,466 SO I'M SO GRATEFUL TO HEAR THE 2837 02:11:14,533 --> 02:11:15,634 INCLUDE PROJECT STARTING TO HELP 2838 02:11:15,701 --> 02:11:16,768 US DEVELOP THE INFRASTRUCTURE TO 2839 02:11:16,835 --> 02:11:20,606 SHARE THE TYPES OF DATA SETS. 2840 02:11:20,672 --> 02:11:24,276 NEXT I'LL COMMENT ON CHALLENGES 2841 02:11:24,343 --> 02:11:25,844 FOR TRANSLATABILITY OF BASIC 2842 02:11:25,911 --> 02:11:27,279 DOWN SYNDROME RESEARCH. 2843 02:11:27,346 --> 02:11:28,847 MY SON MAX HAS DOWN SYNDROME. 2844 02:11:28,914 --> 02:11:31,850 HE'S 13 YEARS OLD. 2845 02:11:31,917 --> 02:11:35,954 HE'S NON SPEAKING BUT 2846 02:11:36,021 --> 02:11:38,223 COMMUNICATING USING ELECTRONIC 2847 02:11:38,290 --> 02:11:39,925 AUGMENTATIVE COMMUNICATION OR 2848 02:11:39,992 --> 02:11:40,359 AAC. 2849 02:11:40,425 --> 02:11:42,394 I SHOWED SOME SLIDES TO MAX AND 2850 02:11:42,461 --> 02:11:48,000 ASKED HIM IF IT'S OKAY IF WE 2851 02:11:48,066 --> 02:11:52,638 SHARE SOME INFORMATION ABOUT HIM 2852 02:11:52,704 --> 02:11:56,174 TO HELP SCIENTISTS AND HE USED 2853 02:11:56,241 --> 02:11:58,610 CHAT POWER TO SAY YES, THIS IS 2854 02:11:58,677 --> 02:12:00,178 OKAY WITH HIM. 2855 02:12:00,245 --> 02:12:04,950 SO MAX IS AUTISTIC AND HAS DOWN 2856 02:12:05,017 --> 02:12:06,618 SYNDROME AND AUTISM AND INFANT 2857 02:12:06,685 --> 02:12:09,288 AS TODDLER HAD DELAYS IN WEANING 2858 02:12:09,354 --> 02:12:11,390 OR TRANSITION FROM DRINKING FROM 2859 02:12:11,456 --> 02:12:13,659 A BOTTLE TO BE ABLE TO DRINK OUT 2860 02:12:13,725 --> 02:12:15,394 OF AN OPEN CUP. 2861 02:12:15,460 --> 02:12:18,096 IT TOOK HIM A LONG TIME TO BEGIN 2862 02:12:18,163 --> 02:12:22,601 TO TRANSITION TO TOLERATE A 2863 02:12:22,668 --> 02:12:26,338 RANGE FOODS AND NOT MANY FOODS 2864 02:12:26,405 --> 02:12:28,607 HE'S ABLE TO EAT AND CAN CHEW 2865 02:12:28,674 --> 02:12:31,310 BUT MAY SPIT WITHOUT SWALLOWING. 2866 02:12:31,376 --> 02:12:33,912 HE'S NOT ABLE TO EXPLAIN TO US 2867 02:12:33,979 --> 02:12:35,447 WHAT HIS EXPERIENCE IS LIKE WHY 2868 02:12:35,514 --> 02:12:36,715 IS HE SPITTING IT OUT RATHER 2869 02:12:36,782 --> 02:12:41,119 THAN SWALLOWING IT. 2870 02:12:41,186 --> 02:12:43,655 HE HAS COMMUNICATION 2871 02:12:43,722 --> 02:12:45,090 DISABILITIES AND SEVERAL OTHER 2872 02:12:45,157 --> 02:12:45,657 SUPPORT NEEDS. 2873 02:12:45,724 --> 02:12:48,260 SO OUR EXPERIENCE HAS BEEN THAT 2874 02:12:48,327 --> 02:12:51,096 SOME ASPECTS OF VIDEO FLEUR OWE 2875 02:12:51,163 --> 02:12:56,201 SCOPIC STUDY STUDIES AND ROUTINE 2876 02:12:56,268 --> 02:12:59,371 EXAMS AND DENTAL CLEANINGS ARE 2877 02:12:59,438 --> 02:13:01,573 NOT STRAIGHTFORWARD FOR HIM AND 2878 02:13:01,640 --> 02:13:04,676 WHAT IS A REGULAR OFFICE VISIT 2879 02:13:04,743 --> 02:13:07,412 MAY REQUIRE SEDATION IN THE O.R. 2880 02:13:07,479 --> 02:13:08,146 FOR MAX. 2881 02:13:08,213 --> 02:13:10,582 HE'S PERCEIVED BY OTHERS AS 2882 02:13:10,649 --> 02:13:13,785 UNABLE TO FOLLOW ONE-STEP 2883 02:13:13,852 --> 02:13:19,224 INSTRUCTIONS OR COMMUNICATE AND 2884 02:13:19,291 --> 02:13:22,594 UNABLE TO REPORT SIDE EFFECTS 2885 02:13:22,661 --> 02:13:26,798 AND ADD TO EXPERIENCES THAT ARE 2886 02:13:26,865 --> 02:13:28,033 ASSOCIATED WITH MEDICAL 2887 02:13:28,100 --> 02:13:28,333 PROCEDURES. 2888 02:13:28,400 --> 02:13:30,202 WE FOUND OVER THE PAST 10 YEARS 2889 02:13:30,268 --> 02:13:32,070 THAT DAYCARES IN SCHOOLS IN OUR 2890 02:13:32,137 --> 02:13:34,139 COMMUNITY WERE CONSISTENTLY 2891 02:13:34,206 --> 02:13:35,040 UNABLE TO PROVIDE SOME OF THE 2892 02:13:35,107 --> 02:13:37,476 APPROPRIATE ACCOMMODATIONS WE 2893 02:13:37,542 --> 02:13:39,311 NEEDED TO SUPPORT MAX'S 2894 02:13:39,378 --> 02:13:40,445 COMMUNICATION DISABILITIES AND 2895 02:13:40,512 --> 02:13:41,279 FEEDING CHALLENGES. 2896 02:13:41,346 --> 02:13:43,815 THESE TYPES OF BARRIERS TO 2897 02:13:43,882 --> 02:13:44,816 DISABILITY ACCOMMODATIONS CAN BE 2898 02:13:44,883 --> 02:13:45,384 DEVASTATING FOR HEALTH AND 2899 02:13:45,450 --> 02:13:46,952 DEVELOPMENT. 2900 02:13:47,018 --> 02:13:49,821 AND THESE ARE DISABILITY 2901 02:13:49,888 --> 02:13:51,890 ACCOMMODATIONS FEASIBLE AND MAY 2902 02:13:51,957 --> 02:13:54,593 BE REQUIRED IN THEORY BUT IN 2903 02:13:54,659 --> 02:14:04,503 SOME COMMUNITIES MAY NOT BE PLUM 2904 02:14:04,803 --> 02:14:07,706 -- AVAILABLE DUE TO FUNDING OR 2905 02:14:07,773 --> 02:14:09,541 COMPLICATED SOCIAL, STRUCTURAL. 2906 02:14:09,608 --> 02:14:11,543 THESE BARRIERS WE MIGHT THINK 2907 02:14:11,610 --> 02:14:13,245 ABOUT WITHIN THE FRAMEWORK OF 2908 02:14:13,311 --> 02:14:16,114 THE SOCIAL MODEL OF DISABILITY 2909 02:14:16,181 --> 02:14:17,949 RATHER THAN THE MEDICAL MODEL OF 2910 02:14:18,016 --> 02:14:18,250 DISABILITY. 2911 02:14:18,316 --> 02:14:19,985 BECAUSE OF THESE BARRIERS SOME 2912 02:14:20,051 --> 02:14:21,686 INDIVIDUALS WITH DOWN SYNDROME 2913 02:14:21,753 --> 02:14:25,357 MAY NOT ABLE TO FULLY ACCESS THE 2914 02:14:25,424 --> 02:14:27,759 BENEFITS OF TREATMENT OPTION AND 2915 02:14:27,826 --> 02:14:30,328 IF THE BARRIERS AREN'T 2916 02:14:30,395 --> 02:14:31,062 ADDRESSED, SOME INDIVIDUALS WITH 2917 02:14:31,129 --> 02:14:33,198 DOWN SYNDROME MAY NOT BE ABLE TO 2918 02:14:33,265 --> 02:14:35,066 ACCESS THE BENEFITS OF THE 2919 02:14:35,133 --> 02:14:36,868 FUTURE OR EMERGING KNOWLEDGE OR 2920 02:14:36,935 --> 02:14:37,769 TREATMENTS WE'RE ALL WORKING ON 2921 02:14:37,836 --> 02:14:40,539 NOW WITH OUR RESEARCH. 2922 02:14:40,605 --> 02:14:45,177 AND I THINK THIS MIGHT IMPACT 2923 02:14:45,243 --> 02:14:47,546 THE RESEARCH. 2924 02:14:47,612 --> 02:14:50,382 WE WANT RESOURCES AND DISCOVERY 2925 02:14:50,449 --> 02:14:54,019 WE GENERATE WITH OUR RESEARCH TO 2926 02:14:54,085 --> 02:14:55,253 BE ABLE HELP EVERYBODY 2927 02:14:55,320 --> 02:14:56,221 REGARDLESS OF THEIR SUPPORT 2928 02:14:56,288 --> 02:14:56,421 NEEDS. 2929 02:14:56,488 --> 02:14:58,890 WE WANT TO HELP PEOPLE WITH LOW 2930 02:14:58,957 --> 02:14:59,991 SUPPORT NEEDS AND ALSO PEOPLE 2931 02:15:00,058 --> 02:15:02,327 WITH HIGH SUPPORT NEEDS. 2932 02:15:02,394 --> 02:15:06,198 SOME CONCLUDING THOUGHTS, BASIC 2933 02:15:06,264 --> 02:15:07,165 RESEARCH IS SO ESSENTIAL BECAUSE 2934 02:15:07,232 --> 02:15:11,002 IT HELPS US REFINE IDEAS AND 2935 02:15:11,069 --> 02:15:11,636 HYPOTHESES AS MUCH AS POSSIBLE 2936 02:15:11,703 --> 02:15:14,105 ABOUT BRINGING THEM TO THE 2937 02:15:14,172 --> 02:15:14,339 CLINIC. 2938 02:15:14,406 --> 02:15:15,974 AND THIS VERY VALUABLE IF ACCESS 2939 02:15:16,041 --> 02:15:18,443 TO CLINICAL CARE MAY BE COMPLEX 2940 02:15:18,510 --> 02:15:21,079 FOR SOME PEOPLE WITH DOWN 2941 02:15:21,146 --> 02:15:21,947 SYNDROME. 2942 02:15:22,013 --> 02:15:26,518 I THINK INFORMATION AND 2943 02:15:26,585 --> 02:15:28,854 SUPPOR 2944 02:15:28,920 --> 02:15:31,456 SUPPORTING VARIABILITY WILL BE 2945 02:15:31,523 --> 02:15:32,224 NEEDED TO TRANSLATE BASIC 2946 02:15:32,290 --> 02:15:33,391 RESEARCH TO BENEFIT INDIVIDUALS 2947 02:15:33,458 --> 02:15:35,594 WITH DOWN SYNDROME. 2948 02:15:35,660 --> 02:15:37,028 AND THESE ARE OUR 2949 02:15:37,095 --> 02:15:37,429 ACKNOWLEDGEMENTS. 2950 02:15:37,496 --> 02:15:46,972 THANK YOU. 2951 02:15:47,038 --> 02:15:48,673 >> THANK YOU. 2952 02:15:48,740 --> 02:15:58,049 OUR NEXT PANEL TO SPEAK WILL BE 2953 02:15:58,116 --> 02:15:58,450 LAU 2954 02:15:58,517 --> 02:16:05,156 LAURA DERUISEAU. 2955 02:16:05,223 --> 02:16:07,893 >> THANK YOU TO THE ORGANIZERS 2956 02:16:07,959 --> 02:16:09,294 FOR RUNNING A SMOOTH MEETING AND 2957 02:16:09,361 --> 02:16:10,896 FOR THE TOWN HAVE THESE 2958 02:16:10,962 --> 02:16:12,998 DISCUSSIONS TODAY. 2959 02:16:13,064 --> 02:16:14,566 OF IT -- THE OPPORTUNITY TO HAVE 2960 02:16:14,633 --> 02:16:16,835 THESE DISCUSSIONS TODAY. 2961 02:16:16,902 --> 02:16:20,505 I WANT TO START WITH OVER ALL 2962 02:16:20,572 --> 02:16:21,172 CONSIDERATIONS IN VARIABILITY IN 2963 02:16:21,239 --> 02:16:21,973 MOUSE STUDIES. 2964 02:16:22,040 --> 02:16:24,209 I'LL TALK ABOUT SOME SOURCES. 2965 02:16:24,276 --> 02:16:26,778 CAGE STYLE GROUP VERSUS SINGLE 2966 02:16:26,845 --> 02:16:28,680 HOUSING, AMBIENT TEMPERATURE OF 2967 02:16:28,747 --> 02:16:32,617 HOUSING AND OF COURSE CIRCADIAN 2968 02:16:32,684 --> 02:16:34,352 DIFFERENCES DEPENDING ON THE 2969 02:16:34,419 --> 02:16:35,186 PHYSIOLOGICAL VARIABLE YOU'RE 2970 02:16:35,253 --> 02:16:35,754 INVESTIGATING. 2971 02:16:35,820 --> 02:16:38,290 I WANT TO PLANT A SEED THAT MICE 2972 02:16:38,356 --> 02:16:40,025 ARE NOT SMALL RATS. 2973 02:16:40,091 --> 02:16:42,193 SOME INVESTIGATIONS MAY NEED 2974 02:16:42,260 --> 02:16:43,094 SOME TWEAKING BEFORE BEING 2975 02:16:43,161 --> 02:16:49,634 IMPLEMENTS IN MICE. 2976 02:16:49,701 --> 02:16:57,976 AND BRIEFLY MANY IN SYSTEMS USE 2977 02:16:58,043 --> 02:17:01,413 THE SYSTEM ON THE LEFT THE 2978 02:17:01,479 --> 02:17:03,448 VENTILATED CAGE SYSTEM AND MAYBE 2979 02:17:03,515 --> 02:17:06,217 THE MORE TRADITIONAL MODEL WOULD 2980 02:17:06,284 --> 02:17:10,488 BE THE WIRE TOPPED CAGE WHERE 2981 02:17:10,555 --> 02:17:11,756 MICE CAN CLIMB. 2982 02:17:11,823 --> 02:17:14,492 AND ONE SOURCE OF VARIABILITY 2983 02:17:14,559 --> 02:17:16,061 THAT CAN BE AGAIN DIFFERENT 2984 02:17:16,127 --> 02:17:18,697 LABORATORIES AND THEY OBSERVED 2985 02:17:18,763 --> 02:17:21,232 LOWER BODY WEIGHT AND HIGHER 2986 02:17:21,299 --> 02:17:24,269 CORE TEMPERATURE IN THE ANIMALS 2987 02:17:24,336 --> 02:17:25,270 THAT HAD ACCESS TO THE WIRE 2988 02:17:25,337 --> 02:17:27,572 TOPPED CAGE AND MORE THAN HALF 2989 02:17:27,639 --> 02:17:29,941 THEIR MICE HAD TO BE SEPARATED 2990 02:17:30,008 --> 02:17:30,809 DUE TO FIGHTING. 2991 02:17:30,875 --> 02:17:34,479 SO HALF OF THEIR ANIMALS WERE 2992 02:17:34,546 --> 02:17:36,781 SINGLY HOUSED AND GROUP HOUSED. 2993 02:17:36,848 --> 02:17:37,949 THAT'S ANOTHER SOURCE OF 2994 02:17:38,016 --> 02:17:38,550 POTENTIAL VARIABILITY. 2995 02:17:38,617 --> 02:17:40,485 THERE'S MORE PUBLICATIONS ON 2996 02:17:40,552 --> 02:17:42,354 GROUP VERSUS SINGLE HOUSING BUT 2997 02:17:42,420 --> 02:17:43,722 WE STILL HAVEN'T SOLVED THE 2998 02:17:43,788 --> 02:17:44,756 PROBLEM AND IT'S ESPECIALLY 2999 02:17:44,823 --> 02:17:46,358 IMPORTANT FOR AGING STUDIES OF 3000 02:17:46,424 --> 02:17:49,728 MICE HAVE TO BE SEPARATED FOR 3001 02:17:49,794 --> 02:17:50,729 FIGHTING AT SOME POINT. 3002 02:17:50,795 --> 02:17:54,599 AND IT'S OFTEN RECOMMENDED TO 3003 02:17:54,666 --> 02:17:57,235 GROUP HOUSED MICE BECAUSE 3004 02:17:57,302 --> 02:18:00,238 THEY'RE SOCIAL ANIMALS HOWEVER, 3005 02:18:00,305 --> 02:18:02,607 MALE GROUPED MICE HAVE HIGHER 3006 02:18:02,674 --> 02:18:05,076 CORTISOL LEVEL AND HAVE TO BE 3007 02:18:05,143 --> 02:18:07,379 SEPARATED AT A LATER TIME POINT. 3008 02:18:07,445 --> 02:18:12,651 THE PAPER WITH GROUP HOUSING IN 3009 02:18:12,717 --> 02:18:13,318 FEMALE MOUSE AND ANOTHER 3010 02:18:13,385 --> 02:18:14,653 RECOMMENDATION IS THEY CAN 3011 02:18:14,719 --> 02:18:16,187 HUDDLE TO MAINTAIN BODY 3012 02:18:16,254 --> 02:18:16,788 TEMPERATURE AND HIS GROUP 3013 02:18:16,855 --> 02:18:21,126 OBSERVED THAT WASN'T THE CASE. 3014 02:18:21,192 --> 02:18:22,427 THAT WAS WITH FEMALE MICE. 3015 02:18:22,494 --> 02:18:26,998 HIS GROUP HAS DONE WORK WITH 3016 02:18:27,065 --> 02:18:28,266 AMBIENT TEMPERATURE AND 3017 02:18:28,333 --> 02:18:28,867 AUTONOMIC FUNCTION. 3018 02:18:28,933 --> 02:18:33,838 THIS DATA SHOWS AS TEMPERATURE 3019 02:18:33,905 --> 02:18:35,840 GOES DOWN, FROM 30 TO 20 THE 3020 02:18:35,907 --> 02:18:37,909 DOTTED LINE AND ON THE OTHER 3021 02:18:37,976 --> 02:18:40,612 SIDE FROM 20 TO 30, HEART RATE 3022 02:18:40,679 --> 02:18:42,213 IS ADVERSELY RELATED. 3023 02:18:42,280 --> 02:18:45,250 SO AS TEMPERATURE GOES FROM 30 3024 02:18:45,316 --> 02:18:49,054 TO 20, HEART RATE GOES UP AND 3025 02:18:49,120 --> 02:18:51,756 FROM 20 TO 30 HEART RATE GOES 3026 02:18:51,823 --> 02:18:57,862 DOWN AN IT'S AUTONOMICLY 3027 02:18:57,929 --> 02:19:01,132 MEDIATED SO IT'S IMPORTANT TO 3028 02:19:01,199 --> 02:19:02,634 REPORT THE TEMPERATURES. 3029 02:19:02,701 --> 02:19:05,370 WE CHOSE THE MID POINT BETWEEN 3030 02:19:05,437 --> 02:19:08,640 20 AND 30 AND THESE ALL WERE 3031 02:19:08,707 --> 02:19:11,342 PERFORMED WITH THE WIRE TOP 3032 02:19:11,409 --> 02:19:11,643 CAGES. 3033 02:19:11,710 --> 02:19:13,912 WE HAVE SHOWN BLOOD PRESSURE IS 3034 02:19:13,978 --> 02:19:17,782 LOWER IN DS69DN AND DID NOT 3035 02:19:17,849 --> 02:19:20,285 CHANGE BETWEEN 6 AND 12 MONTHS 3036 02:19:20,351 --> 02:19:25,857 AND IN WILD TYPE THERE'S AN 3037 02:19:25,924 --> 02:19:27,092 INCREASE IN BLOOD PRESSURE AS 3038 02:19:27,158 --> 02:19:32,130 THEY MATURE DUE TO ARTERIAL 3039 02:19:32,197 --> 02:19:33,531 STIFFNESS AN THERE'S A STRAIN 3040 02:19:33,598 --> 02:19:37,202 AND AGE EFFECT AND INTERACTIONS. 3041 02:19:37,268 --> 02:19:38,503 SO IT'S IMPORTANT WE ARE ABLE TO 3042 02:19:38,570 --> 02:19:41,406 STUDY THE ANIMALS AT VARIOUS 3043 02:19:41,473 --> 02:19:43,475 TIME POINTS BECAUSE SOME THINGS 3044 02:19:43,541 --> 02:19:47,479 WILL NOT MANIFEST UNTIL A 3045 02:19:47,545 --> 02:19:49,481 DIFFERENT AGE POINT AND HIGH 3046 02:19:49,547 --> 02:19:55,286 POXEMIA IS ANOTHER TIME POINT 3047 02:19:55,353 --> 02:19:58,590 AND THEY'RE DEVELOPING THEIR 3048 02:19:58,656 --> 02:20:00,291 BREEDING AND HAVE AS MANY HIGH 3049 02:20:00,358 --> 02:20:02,861 POXEMIA AND IT'S IMPORTANT WE 3050 02:20:02,927 --> 02:20:04,829 CONTINUE TO STUDY THEM AND 3051 02:20:04,896 --> 02:20:06,698 OBSERVED THE SAME PHENOMENON IN 3052 02:20:06,765 --> 02:20:11,503 MORE ELABORATE STUDY OF B6 3053 02:20:11,569 --> 02:20:11,770 ANIMALS. 3054 02:20:11,836 --> 02:20:15,673 AND LASTLY, WE DON'T SEE 3055 02:20:15,740 --> 02:20:18,343 DIFFERENCES IN GAS EXPOSURES. 3056 02:20:18,409 --> 02:20:25,116 WITH HYPERCAPNIA AND SEE THE 3057 02:20:25,183 --> 02:20:26,751 RESPIRATORY SYSTEM AN DON'T SEE 3058 02:20:26,818 --> 02:20:27,886 DIFFERENCES BETWEEN 12 MONTHS 3059 02:20:27,952 --> 02:20:31,122 BETWEEN TS65DN AND WILD TYPE BUT 3060 02:20:31,189 --> 02:20:34,526 THERE'S A BLUNTED RESPONSE AT 12 3061 02:20:34,592 --> 02:20:34,793 MONTHS. 3062 02:20:34,859 --> 02:20:37,796 THE DATA TO THIS POINT WERE 3063 02:20:37,862 --> 02:20:38,963 PERFORMED IN THE LIFE CYCLE BUT 3064 02:20:39,030 --> 02:20:41,499 IT'S IMPORTANT TO RECOGNIZE 3065 02:20:41,566 --> 02:20:43,368 THERE'S DIFFERENCES ACROSS THE 3066 02:20:43,434 --> 02:20:44,836 CIRCADIAN CYCLE AND THEY'RE 3067 02:20:44,903 --> 02:20:46,070 LOWER IN THE LIFE CYCLE COMPARED 3068 02:20:46,137 --> 02:20:50,308 TO THE LIGHT AND LOWER IN TS65DN 3069 02:20:50,375 --> 02:20:53,444 COMPARED TO WILD TYPE. 3070 02:20:53,511 --> 02:20:58,416 AND WHEN WE COMPARE BREEDING 3071 02:20:58,483 --> 02:20:59,851 WE'RE ABLE TO OBSERVE 3072 02:20:59,918 --> 02:21:00,585 DIFFERENCES AND WILD TYPE 3073 02:21:00,652 --> 02:21:02,587 ANIMALS HAVE AN INCREASE IN THE 3074 02:21:02,654 --> 02:21:06,090 RESPONSE TO BOTH HYPOXIA AND IN 3075 02:21:06,157 --> 02:21:08,960 THE DARK CYCLE COMPARED TO THE 3076 02:21:09,027 --> 02:21:11,129 LIGHT CYCLE AND THE TRISOMIC 3077 02:21:11,196 --> 02:21:14,098 ANIMALS THE 65DN HAVE NO 3078 02:21:14,165 --> 02:21:15,066 DIFFERENCE BETWEEN LIGHT AND 3079 02:21:15,133 --> 02:21:17,869 DARK CYCLE RESPONSES AND WE'RE 3080 02:21:17,936 --> 02:21:19,070 ABLE TO RECOGNIZE THESE EARLIER 3081 02:21:19,137 --> 02:21:20,205 WHEN COMPARING ACROSS THE LIGHT 3082 02:21:20,271 --> 02:21:22,740 AND DARK CIRCLES. 3083 02:21:22,807 --> 02:21:24,576 BRIEFLY, CAGE STYLE SINGLE 3084 02:21:24,642 --> 02:21:25,877 VERSUS GROUP HOUSING AND AMBIENT 3085 02:21:25,944 --> 02:21:27,712 TEMPERATURE AND TIME OF DAY ARE 3086 02:21:27,779 --> 02:21:28,713 ALL POINTS OF DISCUSSION WE CAN 3087 02:21:28,780 --> 02:21:30,615 TALK ABOUT LATER AND OF COURSE 3088 02:21:30,682 --> 02:21:31,716 MULTIPLE OTHER CONSIDERATIONS 3089 02:21:31,783 --> 02:21:34,252 THAT I WON'T HAVE A CHANCE TO 3090 02:21:34,319 --> 02:21:34,986 TALK ABOUT TODAY. 3091 02:21:35,053 --> 02:21:37,222 VERY BRIEFLY I WANTED TO TALK 3092 02:21:37,288 --> 02:21:38,223 ABOUT BASELINE CONSIDERATIONS 3093 02:21:38,289 --> 02:21:41,226 AND CONSCIOUS EXPERIMENTS. 3094 02:21:41,292 --> 02:21:45,797 WHEN WE FIRST STARTED STUDYING 3095 02:21:45,864 --> 02:21:47,098 DS65DN WE HAD TO BE MORE 3096 02:21:47,165 --> 02:21:49,334 FLEXIBLE ABOUT HOW WE WERE GOING 3097 02:21:49,400 --> 02:21:51,369 TO COMPARE BASELINE BECAUSE 3098 02:21:51,436 --> 02:21:54,672 TYPICALLY WE'D PUT AN ANIMAL IN 3099 02:21:54,739 --> 02:21:57,041 THE CHAMBER OVER HERE. 3100 02:21:57,108 --> 02:21:58,910 AND EITHER PUT IT ON MULTIPLE 3101 02:21:58,977 --> 02:22:01,746 DAYS LIKE THREE OR FOUR DAYS AND 3102 02:22:01,813 --> 02:22:06,985 EVENTUALLY ACCLIMATE OR HA B 3103 02:22:07,051 --> 02:22:07,585 HABITU 3104 02:22:07,652 --> 02:22:07,986 HABITUATE. 3105 02:22:08,052 --> 02:22:11,522 WE DID NOT FIND THE CASE FOR 3106 02:22:11,589 --> 02:22:14,425 TS65DN AND HAD TO FIND ANOTHER 3107 02:22:14,492 --> 02:22:15,326 ALTERNATIVE AND LOOKED AT A 3108 02:22:15,393 --> 02:22:17,662 SMALLER SEGMENT OF BASELINE 3109 02:22:17,729 --> 02:22:20,265 INSTEAD OF A 10 OR 20 MINUTE 3110 02:22:20,331 --> 02:22:22,967 BASELINE AND FOUND A SEGMENT 3111 02:22:23,034 --> 02:22:24,769 CALM BREATHING IN THE LIGHT AND 3112 02:22:24,836 --> 02:22:28,339 DARK CIRCLE AND FELT THAT WAS 3113 02:22:28,406 --> 02:22:29,474 APPROPRIATE BECAUSE WHEN WE 3114 02:22:29,540 --> 02:22:30,475 COMPARE GAS CHALLENGES OVER HERE 3115 02:22:30,541 --> 02:22:32,644 HOPEFULLY YOU CAN SEE FROM THE 3116 02:22:32,710 --> 02:22:37,582 TRACING THAT THERE'S STUDY 3117 02:22:37,649 --> 02:22:38,850 BREATHING COMPARABLE TO THE CALM 3118 02:22:38,917 --> 02:22:39,250 BREATHING. 3119 02:22:39,317 --> 02:22:41,152 IT'S IMPORTANT TO RECOGNIZE 3120 02:22:41,219 --> 02:22:43,254 WHATEVER OUR BASELINE MEASURES 3121 02:22:43,321 --> 02:22:45,957 ARE TO FULLY CLARIFY THEM AND 3122 02:22:46,024 --> 02:22:51,329 COMPARE ACROSS GROUPS THE DATA 3123 02:22:51,396 --> 02:22:53,965 ARE SHOWING WITH THE CALM 3124 02:22:54,032 --> 02:22:56,367 BREATHING RATE IS LOWER COMPARED 3125 02:22:56,434 --> 02:22:57,835 TO THE LARGER 10-MINUTE BASELINE 3126 02:22:57,902 --> 02:23:00,738 AND IT'S MORE VARIABLE AND WHEN 3127 02:23:00,805 --> 02:23:02,607 WE COMPARE GAS CHALLENGES SUCH 3128 02:23:02,674 --> 02:23:04,742 AS HYPOXIA COMPARED TO THE 3129 02:23:04,809 --> 02:23:08,012 BASELINE STARTING AT A LOWER 3130 02:23:08,079 --> 02:23:09,614 BASELINE THAT PERCENT CHANGE IS 3131 02:23:09,681 --> 02:23:11,983 GREATER AND OBSERVED CIRCADIAN 3132 02:23:12,050 --> 02:23:12,417 S. 3133 02:23:12,483 --> 02:23:16,821 I WANT TO END WITH NORMALIZATION 3134 02:23:16,888 --> 02:23:17,188 CONSIDERATIONS. 3135 02:23:17,255 --> 02:23:18,957 HEAR THE RATE AND BLOOD PRESSURE 3136 02:23:19,023 --> 02:23:20,124 AND MANY OF THESE ARE DIFFERENT 3137 02:23:20,191 --> 02:23:23,061 IN ANIMAL MODELS OF DOWN 3138 02:23:23,127 --> 02:23:24,195 SYNDROME AND INDIVIDUALS WITH 3139 02:23:24,262 --> 02:23:24,529 DOWN SYNDROME. 3140 02:23:24,595 --> 02:23:27,765 USING THE METRICS AS A TYPICAL 3141 02:23:27,832 --> 02:23:37,141 NORMALIZE EVER -- NORMALIZER 3142 02:23:37,208 --> 02:23:40,578 ACROSS MAY SHOW DIFFERENCES AND 3143 02:23:40,645 --> 02:23:44,682 WHEN WE NORMALIZE HERE TO THE 3144 02:23:44,749 --> 02:23:45,350 LOWER BLOOD PRESSURE OF COURSE 3145 02:23:45,416 --> 02:23:47,251 IT'S INVERTED. 3146 02:23:47,318 --> 02:23:48,686 I THINK IT'S IMPORTANT WE 3147 02:23:48,753 --> 02:23:52,590 DISCUSS THE RAW AND POTENTIAL 3148 02:23:52,657 --> 02:23:52,890 NORMALIZERS. 3149 02:23:52,957 --> 02:23:54,692 WE'VE ALSO SHOWN SMALLER HEARTS 3150 02:23:54,759 --> 02:24:02,600 IN TS65DN THROUGH ECHO AND LESS 3151 02:24:02,667 --> 02:24:05,303 VENTRICULAR ANTERIOR WALL 3152 02:24:05,370 --> 02:24:07,705 THICKNESS AND POSTMORTEM AND IF 3153 02:24:07,772 --> 02:24:09,340 WE NORMALIZE TO BODY WEIGHT I 3154 02:24:09,407 --> 02:24:10,975 WOULD FIRST OFFER I THINK THAT 3155 02:24:11,042 --> 02:24:13,411 WAS APPROPRIATE SINCE THIS WAS A 3156 02:24:13,478 --> 02:24:14,979 BODY WEIGHT BY STRAIN 3157 02:24:15,046 --> 02:24:15,413 INTERACTION. 3158 02:24:15,480 --> 02:24:18,950 THESE TWO WERE CHANGING 3159 02:24:19,017 --> 02:24:19,250 DIFFERENTLY. 3160 02:24:19,317 --> 02:24:21,219 BUT ALSO THERE'S A LOT TO 3161 02:24:21,285 --> 02:24:22,520 CONSIDER IN THE SCENARIO. 3162 02:24:22,587 --> 02:24:24,922 IF THE MICE ARE BORN SMALLER AND 3163 02:24:24,989 --> 02:24:26,290 STAY SMALLER THEIR WHOLE LIVES 3164 02:24:26,357 --> 02:24:29,627 MAYBE IT'S TYPICAL TO HAVE 3165 02:24:29,694 --> 02:24:30,928 SMALLER HEARTS AND SOME HAVE 3166 02:24:30,995 --> 02:24:33,364 SIMILAR WEIGHTS AT YOUNG AGES 3167 02:24:33,431 --> 02:24:35,600 AND THEN LOSE WEIGHT OVER TIME 3168 02:24:35,666 --> 02:24:37,335 SO POTENTIALLY THEIR PHYSIOLOGY 3169 02:24:37,402 --> 02:24:39,337 AFFECTING THE WEIGHT LOSS AND 3170 02:24:39,404 --> 02:24:42,573 POTENTIALLY MUSCLE MASS LOSS AND 3171 02:24:42,640 --> 02:24:44,409 OTHER LEAN MASS ISSUES. 3172 02:24:44,475 --> 02:24:46,411 WE'RE NOT THE ONLY GROUP 3173 02:24:46,477 --> 02:24:47,879 CONCERNED ABOUT NORMALIZING FOR 3174 02:24:47,945 --> 02:24:50,615 CARDIOVASCULAR VARIABLES. 3175 02:24:50,681 --> 02:24:54,952 THIS IS AN EXTENSIVE 3176 02:24:55,019 --> 02:24:55,253 PUBLICATION. 3177 02:24:55,319 --> 02:25:00,091 I RECOMMEND IT FOR NORMALIZING 3178 02:25:00,158 --> 02:25:02,493 FOR WEIGHT AND THIS FOR SICKER 3179 02:25:02,560 --> 02:25:03,494 ANIMALS AND A LOT OF THEIR WORK 3180 02:25:03,561 --> 02:25:07,031 WAS DONE IN HEALTHY YOUNG 3181 02:25:07,098 --> 02:25:07,298 ANIMALS. 3182 02:25:07,365 --> 02:25:10,601 AND THEY RECOMMEND USING TIBIAL 3183 02:25:10,668 --> 02:25:12,703 LENGTH CUBED AS A MODEL IN 3184 02:25:12,770 --> 02:25:18,109 HEALTHY YOUNG MICE TO HELP 3185 02:25:18,176 --> 02:25:19,243 NORMALIZE ACROSS HEART WEIGHT. 3186 02:25:19,310 --> 02:25:27,351 SO SUMMARIZE, MOUSE MODELS OF 3187 02:25:27,418 --> 02:25:30,221 WEIGHTS AND ANY WAY TO 3188 02:25:30,288 --> 02:25:31,923 STANDARDIZE CAN HELP WITH 3189 02:25:31,989 --> 02:25:32,790 REPORTING INFORMATION AND 3190 02:25:32,857 --> 02:25:34,092 HOUSING CONDITIONS CAN HELP 3191 02:25:34,158 --> 02:25:36,027 COMPARE ACROSS GROUPS AND THE 3192 02:25:36,094 --> 02:25:36,894 CHOICE OF BASELINE CAN INFLUENCE 3193 02:25:36,961 --> 02:25:38,696 HOW THE RESPONSE IS QUANTIFIED 3194 02:25:38,763 --> 02:25:41,599 AND PERHAPS LATER WE CAN TALK 3195 02:25:41,666 --> 02:25:43,401 ABOUT POTENTIAL APPROPRIATE 3196 02:25:43,468 --> 02:25:45,536 NORMALIZERS FOR PHYSIOLOGICAL 3197 02:25:45,603 --> 02:25:46,704 DATA SETS IN DOWN SYNDROME. 3198 02:25:46,771 --> 02:25:50,608 AND I'D LIKE TO THANK MANY OF MY 3199 02:25:50,675 --> 02:25:51,943 COLLABORATORS AND MOST OF THE 3200 02:25:52,009 --> 02:25:53,144 WORK WAS PERFORMED BY 3201 02:25:53,211 --> 02:25:53,778 UNDERGRADUATES AS WELL SO THANK 3202 02:25:53,845 --> 02:26:03,921 YOU. 3203 02:26:30,081 --> 02:26:32,783 >> WE'LL HAVE OUR NEXT PANELIST. 3204 02:26:32,850 --> 02:26:33,918 >> THANK YOU SO MUCH. 3205 02:26:33,985 --> 02:26:36,787 SORRY FOR THE TROUBLE FOR THE 3206 02:26:36,854 --> 02:26:37,054 SLIDES. 3207 02:26:37,121 --> 02:26:38,356 IT MADE SENSE FOR THIS TO GO 3208 02:26:38,422 --> 02:26:45,329 AFTER THE MODELS HAVE BEEN 3209 02:26:45,396 --> 02:26:45,730 EXPLAINED ALREADY. 3210 02:26:45,796 --> 02:26:49,567 AND SO I AM VERY HAPPY TO TALK 3211 02:26:49,634 --> 02:26:51,335 TODAY ABOUT OUR EXPERIENCE WITH 3212 02:26:51,402 --> 02:26:52,403 DIFFERENT MOUSE MODELS OF DOWN 3213 02:26:52,470 --> 02:26:53,971 SYNDROME AND I THOUGHT I'D START 3214 02:26:54,038 --> 02:27:04,248 WITH A CHEESEBURGER FIRST. 3215 02:27:04,315 --> 02:27:06,083 THE McDONALD'S CHEESEBURGER IS 3216 02:27:06,150 --> 02:27:09,387 KNOWN FOR BEING THE SAME EVERY 3217 02:27:09,453 --> 02:27:11,189 TIME YOU BUY ONE. 3218 02:27:11,255 --> 02:27:12,890 AND NOR A LONG TIME THAT'S HOW I 3219 02:27:12,957 --> 02:27:14,458 CONSIDERED AND I THINK MANY 3220 02:27:14,525 --> 02:27:15,893 OTHERS CONSIDERED MOUSE MODELS 3221 02:27:15,960 --> 02:27:21,365 OF DOWN SIN -- SYNDROME AND WE 3222 02:27:21,432 --> 02:27:24,135 CONSIDERED THEM TO BE LIKE THE 3223 02:27:24,202 --> 02:27:25,036 PREVIOUS SHIPMENT OF MICE THAT 3224 02:27:25,102 --> 02:27:27,138 WE HAD RECEIVED AND WHAT I WILL 3225 02:27:27,205 --> 02:27:28,005 TELL YOU ABOUT TODAY ARE A 3226 02:27:28,072 --> 02:27:29,674 COUPLE STORIES WHERE WE FOUND 3227 02:27:29,740 --> 02:27:36,380 THIS NOT TO BE THE CASE. 3228 02:27:36,447 --> 02:27:38,082 THERE IS PHENOTYPIC WE 3229 02:27:38,149 --> 02:27:40,351 IDENTIFIED OVER TIME AND THEN I 3230 02:27:40,418 --> 02:27:42,687 WILL SHOW YOU ALSO THIS IS TRUE 3231 02:27:42,753 --> 02:27:44,622 IN TV MAC 21 WE THINK AND THEN 3232 02:27:44,689 --> 02:27:50,494 GO FROM THERE TO TELL YOU ABOUT 3233 02:27:50,561 --> 02:27:54,131 NEW DATA WE'VE DEVELOPED IN THIS 3234 02:27:54,198 --> 02:27:54,799 NEWER MOUSE MODEL OF DOWN 3235 02:27:54,865 --> 02:28:05,042 SYNDROME. 3236 02:28:07,445 --> 02:28:10,681 TS65DN WAS CREATED IN 1990 AND 3237 02:28:10,748 --> 02:28:13,651 IN 2007 WE PUBLISHED A PAPER 3238 02:28:13,718 --> 02:28:15,353 THAT DEMONSTRATED THE PRENATAL 3239 02:28:15,419 --> 02:28:18,322 BRAIN CHARACTERISTICS OF THIS 3240 02:28:18,389 --> 02:28:19,724 MOUSE MODEL OF DOWN SYNDROME. 3241 02:28:19,790 --> 02:28:22,159 ONE OF THE BIGGEST PHENOTYPES 3242 02:28:22,226 --> 02:28:24,996 WAS THIS VERY APPARENT DELAY IN 3243 02:28:25,062 --> 02:28:28,299 GROWTH OF THE CEREBRAL WALL 3244 02:28:28,366 --> 02:28:30,534 COMPARED TO CONTROL ANIMALS OVER 3245 02:28:30,601 --> 02:28:32,970 THE COURSE OF NEURO GENESIS WITH 3246 02:28:33,037 --> 02:28:34,105 PRENATAL DEVELOPMENT. 3247 02:28:34,171 --> 02:28:38,509 YOU CAN SEE THIS CLEARLY HERE. 3248 02:28:38,576 --> 02:28:45,349 AFTER THAT POINT THE TS65DN WAS 3249 02:28:45,416 --> 02:28:46,450 SPLIT INTO TWO. 3250 02:28:46,517 --> 02:28:49,320 THE ORIGINAL WAS THE 1924 LINE 3251 02:28:49,387 --> 02:28:52,990 AND A NEW LINE, 5252 WHICH HAD 3252 02:28:53,057 --> 02:28:55,159 BEEN CORRECTED FOR A GAIN 3253 02:28:55,226 --> 02:28:57,028 MUTATION THAT CAUSED RETINAL 3254 02:28:57,094 --> 02:29:00,698 BLINDNESS IN TS65DN. 3255 02:29:00,765 --> 02:29:03,301 THE 5252 LINE WAS ABLE TO BE 3256 02:29:03,367 --> 02:29:04,435 USED EFFECTIVELY FOR BEHAVIOR 3257 02:29:04,502 --> 02:29:07,238 AND THINGS LIKE THAT. 3258 02:29:07,305 --> 02:29:10,608 ONE OF THE THINGS WE NOTICE THE 3259 02:29:10,675 --> 02:29:12,943 BY CHANCE HAVING GONE BACK AND 3260 02:29:13,010 --> 02:29:14,779 LOOKING AT PRENATAL BRAIN GROWTH 3261 02:29:14,845 --> 02:29:18,482 IN THE ANIMALS AFTER THEY HAD 3262 02:29:18,549 --> 02:29:20,584 BEEN MAINTAINED FOR QUITE SOME 3263 02:29:20,651 --> 02:29:23,187 TIME IS WE HAVE LOST THIS BRAIN 3264 02:29:23,254 --> 02:29:23,721 DEVELOPMENTAL PHENOTYPE. 3265 02:29:23,788 --> 02:29:29,860 AND YOU CAN SEE THIS HERE THE 3266 02:29:29,927 --> 02:29:35,266 MEASUREMENT OF PORTIONS OF THE 3267 02:29:35,333 --> 02:29:36,701 NEOCORTICAL WALL IN THE 5252 3268 02:29:36,767 --> 02:29:38,602 LINE AND THICKER THAN THE 3269 02:29:38,669 --> 02:29:40,504 EUPLOID CONTROL. 3270 02:29:40,571 --> 02:29:44,075 SOMETHING DRASTIC CHANGED IN THE 3271 02:29:44,141 --> 02:29:46,644 MOUSE AND WE ASKED THEM TO 3272 02:29:46,711 --> 02:29:52,450 RECOVER SOME FROZEN EMBRYOS THEY 3273 02:29:52,516 --> 02:29:54,618 BANKED WHEN THEY MADE THE 5252 3274 02:29:54,685 --> 02:29:56,987 LINE AND THIS IS THE BLUE BOX 3275 02:29:57,054 --> 02:29:58,556 THE CRYO 2010. 3276 02:29:58,622 --> 02:30:02,426 YOU CAN SEE THE CORTICAL 3277 02:30:02,493 --> 02:30:03,027 DEVELOPMENTAL PHENOTYPE WAS 3278 02:30:03,094 --> 02:30:04,428 PRESENT IN THOSE ANIMALS THAT 3279 02:30:04,495 --> 02:30:06,831 HAD BEEN FROZEN AT THE ORIGINAL 3280 02:30:06,897 --> 02:30:07,031 STATE. 3281 02:30:07,098 --> 02:30:10,601 OVER THIS TYPE THERE HAS BEEN A 3282 02:30:10,668 --> 02:30:14,038 CHANGE IN THIS VERY MAJOR BRAIN 3283 02:30:14,105 --> 02:30:14,538 DEVELOPMENTAL PHENOTYPE. 3284 02:30:14,605 --> 02:30:15,773 THAT'S POINT NUMBER 1. 3285 02:30:15,840 --> 02:30:19,610 THE FACT THIS CAN HAPPEN. 3286 02:30:19,677 --> 02:30:25,850 AND MORE RECENTLY WE'VE BEEN 3287 02:30:25,916 --> 02:30:30,588 EVALUATING BRAIN DEVELOPMENT IN 3288 02:30:30,654 --> 02:30:33,157 MAC 21 AND THERE'S AGAIN A LONG 3289 02:30:33,224 --> 02:30:35,326 ARM OF HUMAN CHROMOSOME 21 IN 3290 02:30:35,393 --> 02:30:38,662 THE CELLS AND ALSO HAS A NIFTY 3291 02:30:38,729 --> 02:30:40,998 GFP LOCUS ADDED AND YOU CAN SEE 3292 02:30:41,065 --> 02:30:43,968 THE GREEN FLUORESCENT TRISOMIC 3293 02:30:44,034 --> 02:30:45,069 ANIMALS HERE. 3294 02:30:45,136 --> 02:30:47,338 WE HAVE BEEN CHARACTERIZING 3295 02:30:47,405 --> 02:30:50,307 THESE ANIMALS FOR EARLY BRAIN 3296 02:30:50,374 --> 02:30:52,877 DEVELOPMENT UP TO ADULTHOOD 3297 02:30:52,943 --> 02:30:54,478 MEASURING BRAIN GROWTH AND 3298 02:30:54,545 --> 02:30:55,112 DIFFERENT ASPECTS OF CELL 3299 02:30:55,179 --> 02:31:02,720 PROLIFERATION AND SUCH. 3300 02:31:02,787 --> 02:31:05,389 WHAT WE HAVE FOUND FROM OTHER 3301 02:31:05,456 --> 02:31:07,291 ANIMAL MOUSE MODELS IS THERE'S 3302 02:31:07,358 --> 02:31:10,261 NO CHANGE IN SIZE OF THE EMBRYOS 3303 02:31:10,327 --> 02:31:11,829 OR IN GROWTH OF THE BRAIN OVER 3304 02:31:11,896 --> 02:31:12,062 TIME. 3305 02:31:12,129 --> 02:31:15,499 IN FACT, IF YOU LOOK AT CORTICAL 3306 02:31:15,566 --> 02:31:17,501 WALL THICKNESS HERE DURING 3307 02:31:17,568 --> 02:31:21,372 PRENATAL DEVELOPMENT THERE'S NO 3308 02:31:21,439 --> 02:31:26,577 DIFFERENCE BETWEEN TRISOMIC AND 3309 02:31:26,644 --> 02:31:28,345 OOUP -- EUPLOID CONTROLS AND 3310 02:31:28,412 --> 02:31:30,214 THIS IS DIFFERENT FROM A RECENT 3311 02:31:30,281 --> 02:31:34,585 PAPER THAT CAME FROM THE GROUP 3312 02:31:34,652 --> 02:31:37,421 IN JAPAN WHO HAVE ANALYZED 3313 02:31:37,488 --> 02:31:41,091 DEVELOPMENT IN TC MAC 21 AND 3314 02:31:41,158 --> 02:31:50,067 THEY SEE DIFFERENCES IN NEURONAL 3315 02:31:50,134 --> 02:31:51,368 PRODUCTION IN PRENATAL 3316 02:31:51,435 --> 02:31:52,603 DEVELOPMENT AN THERE'S DIFFERENT 3317 02:31:52,670 --> 02:31:54,171 FINDINGS IN LABS AROUND THE 3318 02:31:54,238 --> 02:31:56,440 WORLD STUDYING THE SAME MOUSE. 3319 02:31:56,507 --> 02:31:58,642 ONE OF THE THINGS THAT MAY PLAY 3320 02:31:58,709 --> 02:32:00,044 A ROLE IN THIS IS THAT THE 3321 02:32:00,110 --> 02:32:03,247 ANIMAL WAS FIRST GENERATED IN 3322 02:32:03,314 --> 02:32:07,551 JAPAN AND HAD A PERIOD OF TIME 3323 02:32:07,618 --> 02:32:10,120 WHERE TRANSFER TO THE UNITED 3324 02:32:10,187 --> 02:32:13,123 STATES WAS A BIT DIFFICULT AND 3325 02:32:13,190 --> 02:32:14,525 SO WHAT HAPPENED IN THE END THE 3326 02:32:14,592 --> 02:32:16,694 JAPANESE TEAM CREATED A BUNCH OF 3327 02:32:16,760 --> 02:32:23,567 FROZEN EMBRYOS FROM FEMALES AND 3328 02:32:23,634 --> 02:32:25,636 TRANSLATED THEM TO JACKSON LABS 3329 02:32:25,703 --> 02:32:29,773 AND THOSE WERE RECOVERED AND 3330 02:32:29,840 --> 02:32:32,610 DISTRIBUTED OUT TO INVESTIGATORS 3331 02:32:32,676 --> 02:32:33,077 IN THE UNITED STATES. 3332 02:32:33,143 --> 02:32:36,146 THIS IS POTENTIALLY AN AREA 3333 02:32:36,213 --> 02:32:37,715 WHERE THE ANIMALS MAY HAVE 3334 02:32:37,781 --> 02:32:40,718 DIVERGED TO CREATE DIFFERENCES 3335 02:32:40,784 --> 02:32:41,886 IN THE PHENOTYPES BETWEEN THOSE 3336 02:32:41,952 --> 02:32:44,688 THAT ARE HOUSED IN JAPAN NOW AND 3337 02:32:44,755 --> 02:32:45,456 THOSE BEING SUPPLIED IN THE 3338 02:32:45,523 --> 02:32:45,823 UNITED STATES. 3339 02:32:45,890 --> 02:32:46,624 SO IT'S JUST SOMETHING TO BE 3340 02:32:46,690 --> 02:32:48,659 AWARE OF. 3341 02:32:48,726 --> 02:32:51,829 TO MAKE SURE WE STUDY THESE 3342 02:32:51,896 --> 02:32:54,632 ANIMALS CAREFULLY ENOUGH TO 3343 02:32:54,698 --> 02:32:55,299 QUANTITATIVELY UNDERSTAND WHAT'S 3344 02:32:55,366 --> 02:32:57,401 HAPPENING AND COMPARE THEM TO 3345 02:32:57,468 --> 02:32:59,470 OUR COLLEAGUES. 3346 02:32:59,537 --> 02:33:01,171 THE ANIMALS ARE NOT ALL VARIABLE 3347 02:33:01,238 --> 02:33:02,773 IN ALL DIFFERENCE. 3348 02:33:02,840 --> 02:33:04,575 IN FACT IT TURNS OUT THERE'S 3349 02:33:04,642 --> 02:33:06,544 SOME VERY IMPORTANT SIMILARITIES 3350 02:33:06,610 --> 02:33:08,679 SEEN IN ALL MOUSE MODELS OF DOWN 3351 02:33:08,746 --> 02:33:13,150 SYNDROME AND REPLICATED IN HUMAN 3352 02:33:13,217 --> 02:33:14,118 POSTMORTEM SAMPLES AS WELL. 3353 02:33:14,184 --> 02:33:17,388 THAT HAS TO DO WITH THE CELLULAR 3354 02:33:17,454 --> 02:33:18,689 PROLIFERATION OF THE NEURAL 3355 02:33:18,756 --> 02:33:19,957 PRECURSORS AS THE BRAIN 3356 02:33:20,024 --> 02:33:20,224 DEVELOPS. 3357 02:33:20,291 --> 02:33:23,928 AS YOU ALL PROBABLY KNOW IN THE 3358 02:33:23,994 --> 02:33:25,062 DEVELOPING BRAIN PARTICULARLY IN 3359 02:33:25,129 --> 02:33:27,197 THE CORTEX, THE MAIN STEM CELL 3360 02:33:27,264 --> 02:33:32,036 IS CALLED THE RADIO GLIAL CELLS 3361 02:33:32,102 --> 02:33:35,806 AND DIVIDE TO CREATE THE 3362 02:33:35,873 --> 02:33:37,441 EXCITATORY NEURONS DURING 3363 02:33:37,508 --> 02:33:37,908 PRENATAL DEVELOPMENT. 3364 02:33:37,975 --> 02:33:43,414 THEY DON'T DO THIS ALONE THEY 3365 02:33:43,480 --> 02:33:45,149 HAVE OTHER BASAL AND 3366 02:33:45,215 --> 02:33:47,718 INTERMEDIATE PROGENITORS THAT 3367 02:33:47,785 --> 02:33:49,720 ALSO DIVED TO MAKE THESE AND 3368 02:33:49,787 --> 02:33:52,389 IT'S THE SUITE OF CELLS CREATING 3369 02:33:52,456 --> 02:33:53,791 CELLS DURING PRENATAL 3370 02:33:53,857 --> 02:33:54,091 DEVELOPMENT. 3371 02:33:54,158 --> 02:33:59,964 WHAT WE FOUND IN TS65DN THE 3372 02:34:00,030 --> 02:34:03,434 INTERMEDIATE PROGENITORS WITH 3373 02:34:03,500 --> 02:34:06,670 THE MARKER DIVIDING OUT HERE 3374 02:34:06,737 --> 02:34:10,474 AWAY FROM THE SURFACE OF THE 3375 02:34:10,541 --> 02:34:15,412 VENTRICLE IS DRASTICALLY REDUCED 3376 02:34:15,479 --> 02:34:18,115 THIS BRAIN COMPARED TO EUPLOID 3377 02:34:18,182 --> 02:34:20,017 AND THEY EXPRESS THE 3378 02:34:20,084 --> 02:34:21,852 TRANSCRIPTION FACTOR T BRAIN 2 3379 02:34:21,919 --> 02:34:23,954 OR TBR2 RED IN THE IMMUNOSTAIN. 3380 02:34:24,021 --> 02:34:27,791 YOU CAN SEE THE NUMBERS OF THESE 3381 02:34:27,858 --> 02:34:32,630 PROGENITORS IS DECREASED IN 3382 02:34:32,696 --> 02:34:34,965 TS65DN CORTEX ALSO WITH THIS 3383 02:34:35,032 --> 02:34:36,333 MARKER AND THE QUANTIFICATION IN 3384 02:34:36,400 --> 02:34:37,468 THE RIGHT. 3385 02:34:37,534 --> 02:34:41,438 YOU SEE THE DECREASE IN THE 3386 02:34:41,505 --> 02:34:43,440 INTERMEDIATE PROGENITORS AND THE 3387 02:34:43,507 --> 02:34:46,143 MITOTIC FIGURES OF THE CELLS IN 3388 02:34:46,210 --> 02:34:46,677 C2. 3389 02:34:46,744 --> 02:34:51,115 THE SAME PAPER I WAS REFERENCING 3390 02:34:51,181 --> 02:34:53,817 MEASURED THIS AND THEY SHOW A 3391 02:34:53,884 --> 02:34:57,087 SIGNIFICANT DIFFERENCE OR 3392 02:34:57,154 --> 02:35:02,359 DECREASE IN THESE BASAL 3393 02:35:02,426 --> 02:35:03,761 PRECURSORS DURING PRENATAL 3394 02:35:03,827 --> 02:35:05,896 DEVELOPMENT AND YOU SEE THAT 3395 02:35:05,963 --> 02:35:06,764 QUANTIFICATION HERE. 3396 02:35:06,830 --> 02:35:08,198 TOGETHER THE TWO MOUSE MODELS 3397 02:35:08,265 --> 02:35:12,870 AND DP16 AND OTHER AS WELL HAVE 3398 02:35:12,936 --> 02:35:13,871 DEMONSTRATED ABNORMALITIES IN 3399 02:35:13,937 --> 02:35:16,173 PRECURSOR DEVELOPMENT AND THIS 3400 02:35:16,240 --> 02:35:18,275 MAY BE A COMMON THEME IN 3401 02:35:18,342 --> 02:35:19,977 PRENATAL BRAIN DEVELOPMENT ALSO 3402 02:35:20,044 --> 02:35:24,815 IN PEOPLE WITH DOWN SYNDROME. 3403 02:35:24,882 --> 02:35:30,587 TO LOOK MORE CAREFULLY AT THE 3404 02:35:30,654 --> 02:35:32,990 BASAL PRECURSORS WE'VE USED IN 3405 02:35:33,057 --> 02:35:38,362 UTERO ELECTROPROLIFERATION TO 3406 02:35:38,429 --> 02:35:42,599 DELIVER TOOLS TO LOOK AT THE 3407 02:35:42,666 --> 02:35:44,435 BASAL INTERMEDIATE CELLS AND 3408 02:35:44,501 --> 02:35:46,437 CONTRAST THEM FROM THE STEM 3409 02:35:46,503 --> 02:35:47,137 CELLS. 3410 02:35:47,204 --> 02:35:51,742 AND SO THIS TECHNIQUE INVOLVED 3411 02:35:51,809 --> 02:35:53,977 GENERATING GENE CONSTRUCTS 3412 02:35:54,044 --> 02:35:56,647 INJECTING THEM DIRECTLY INTO THE 3413 02:35:56,714 --> 02:35:59,049 FETAL BRAIN AND TRANSFECTING 3414 02:35:59,116 --> 02:36:00,551 THEM IN THE NEOCORTICAL WALL IN 3415 02:36:00,617 --> 02:36:10,761 THE C2. 3416 02:36:21,004 --> 02:36:24,308 IF WE ADD THE CELLS WE FIND THE 3417 02:36:24,374 --> 02:36:27,444 RADIAL GLIAL CELLS WILL HAVE 3418 02:36:27,511 --> 02:36:32,683 BLUE REPRESENTED IN GREEN HERE 3419 02:36:32,750 --> 02:36:43,293 IN THE SLIDES WE CAN DETERMINE 3420 02:36:50,734 --> 02:36:56,106 THE NUMBER OF PRECURSOR CELLS. 3421 02:36:56,173 --> 02:37:02,579 WHAT WE FOUND QUICKLY IS IN THE 3422 02:37:02,646 --> 02:37:08,619 CONTROL BRAINS WE FIND ABOUT 60% 3423 02:37:08,685 --> 02:37:11,321 ARE PROGENITORS AND IN TC MAC 21 3424 02:37:11,388 --> 02:37:14,792 IT'S OPPOSITE THERE'S 60% RADIO 3425 02:37:14,858 --> 02:37:18,328 GLIA AND FEWER INTERMEDIATE 3426 02:37:18,395 --> 02:37:18,729 PROGENITOR CELLS. 3427 02:37:18,796 --> 02:37:19,930 IN THE NEXT SLIDE I'LL SHOW 3428 02:37:19,997 --> 02:37:20,931 ANOTHER EXPERIMENT. 3429 02:37:20,998 --> 02:37:23,600 WE USED THE SAME TECHNIQUE TO 3430 02:37:23,667 --> 02:37:26,603 ASK IF THE TC MAC HAD FEWER OF 3431 02:37:26,670 --> 02:37:28,505 THE BASAL PROGENITORS WHAT'S 3432 02:37:28,572 --> 02:37:30,274 THIS MEAN IN TERMS OF PRODUCTION 3433 02:37:30,340 --> 02:37:35,112 OF THE NEURONS THEY'RE IT 3434 02:37:35,179 --> 02:37:36,346 GENERATE IN THIS EXPERIMENT SAME 3435 02:37:36,413 --> 02:37:40,951 TOOLS AND WENT TO POST NATAL DAY 3436 02:37:41,018 --> 02:37:41,518 21. 3437 02:37:41,585 --> 02:37:44,621 WE FOUND IN THE CONTROL BRAINS, 3438 02:37:44,688 --> 02:37:50,127 THE NUMBER OF NEURONS DERIVED 3439 02:37:50,194 --> 02:37:53,163 FROM THE RADIO GLIAL CELLS IS 3440 02:37:53,230 --> 02:37:57,000 50% AND 50% FROM THE IMMEDIATE 3441 02:37:57,067 --> 02:38:03,106 PROGENITORS AND IN THE TRISOMIC 3442 02:38:03,173 --> 02:38:05,242 FEWER COME FROM THAT TYPE OF 3443 02:38:05,309 --> 02:38:05,943 PROGENITOR. 3444 02:38:06,009 --> 02:38:08,812 MOST COME FROM THE RADIO GLIAL 3445 02:38:08,879 --> 02:38:09,379 CELLS. 3446 02:38:09,446 --> 02:38:11,782 THE CORTEX IS BUILT GENERALLY 3447 02:38:11,849 --> 02:38:14,051 THE SAME WAY BUT ENDS UP WIN 3448 02:38:14,117 --> 02:38:14,985 NEURONS WITH A SLIGHTLY 3449 02:38:15,052 --> 02:38:17,187 DIFFERENT MIX OF PRODUCTIONAL 3450 02:38:17,254 --> 02:38:19,323 STREAMS AND WE THINK THIS MAY BE 3451 02:38:19,389 --> 02:38:22,359 VERY IMPORTANT IN HOW THE 3452 02:38:22,426 --> 02:38:25,429 CIRCUITRY DEVELOPS AFTER THAT. 3453 02:38:25,495 --> 02:38:27,464 QUICKLY, TAKE HOME MEASURES. 3454 02:38:27,531 --> 02:38:29,433 SOME TAKE-HOME MESSAGES. 3455 02:38:29,499 --> 02:38:32,603 MOUSE MODELS OF DOWN SYNDROME 3456 02:38:32,669 --> 02:38:34,304 SHOULD NOT BE CONSIDERED STABLE 3457 02:38:34,371 --> 02:38:37,941 BY DEFAULT THEY SHOULD BE 3458 02:38:38,008 --> 02:38:38,609 CRITICALLY ANALYZED IN THE LAB 3459 02:38:38,675 --> 02:38:44,081 WHEN THEY'RE RECEIVED. 3460 02:38:44,147 --> 02:38:46,483 AND ALSO IT SEEMS LIKE THERE'S 3461 02:38:46,550 --> 02:38:48,352 BEEN POTENTIAL RESTRICTION 3462 02:38:48,418 --> 02:38:50,487 EVENTS IN TERMS OF THE TC MAC 21 3463 02:38:50,554 --> 02:38:51,488 LINE COMPARED FROM THOSE 3464 02:38:51,555 --> 02:38:53,490 EXISTING IN JAPAN AN THOSE THAT 3465 02:38:53,557 --> 02:39:01,298 ARE NOW PRODUCED IN THE USA. 3466 02:39:01,365 --> 02:39:02,432 THIS CLEARLY IDENTIFIES THE NEED 3467 02:39:02,499 --> 02:39:04,268 FOR HIGH AMOUNT OF RIGOR WHEN 3468 02:39:04,334 --> 02:39:05,969 USING THE ANIMALS FOR 3469 02:39:06,036 --> 02:39:06,270 EXPERIMENTS. 3470 02:39:06,336 --> 02:39:10,007 AND LASTLY, SOME OF THE NEWER 3471 02:39:10,073 --> 02:39:14,344 DATA ON NEURO PROGENITOR ON 3472 02:39:14,411 --> 02:39:15,512 PROLIFERATION SUGGESTS INDIRECT 3473 02:39:15,579 --> 02:39:17,948 NEURAL GENESIS FROM THE BASAL 3474 02:39:18,015 --> 02:39:20,484 CELLS IS DECREASED IN THE ANIMAL 3475 02:39:20,550 --> 02:39:24,922 MODELS OF DOWN SYNDROME AND 3476 02:39:24,988 --> 02:39:26,490 WE'RE INTERESTED HOW THE 3477 02:39:26,556 --> 02:39:30,127 SPECIFIC CHANGE DURING EMBRY ON 3478 02:39:30,193 --> 02:39:33,297 IC DEVELOPMENT CAN CHANGE -- 3479 02:39:33,363 --> 02:39:34,298 EMBRYONIC DEVELOPMENT CAN LEAD 3480 02:39:34,364 --> 02:39:37,134 TO CHANGES IN BRAIN STRUCTURE 3481 02:39:37,200 --> 02:39:41,138 AND I'LL STOP AND THANK TRISH, 3482 02:39:41,204 --> 02:39:43,373 JENNY AND JOE FOR THEIR GREAT 3483 02:39:43,440 --> 02:39:45,475 WORK AND NICHD FOR THEIR GREAT 3484 02:39:45,542 --> 02:39:51,882 FUNDING. 3485 02:39:51,949 --> 02:39:55,452 >> TESTING THE MIC. 3486 02:39:55,519 --> 02:39:58,889 SO NOW IT'S THE OPPORTUNITY IF 3487 02:39:58,956 --> 02:40:01,325 ANYONE IN THE AUDIENCE HAS SOME 3488 02:40:01,391 --> 02:40:03,126 OF THEIR LIVED EXPERIENCES THAT 3489 02:40:03,193 --> 02:40:05,595 YOU WANT TO ADD TO THE 3490 02:40:05,662 --> 02:40:07,397 DISCUSSION OR HAVE QUESTIONS FOR 3491 02:40:07,464 --> 02:40:10,233 ANY OF THE PANELISTS, PLEASE 3492 02:40:10,300 --> 02:40:11,702 COME UP TO THE MIC AND WHILE 3493 02:40:11,768 --> 02:40:18,642 WE'RE WAITING FOR PEOPLE TO COME 3494 02:40:18,709 --> 02:40:26,616 UP, DO ANYTHING PANELISTS HAVE 3495 02:40:26,683 --> 02:40:28,885 QUESTIONS FOR EACH OTHER? 3496 02:40:28,952 --> 02:40:30,420 >> I THINK THIS IS A GREAT THING 3497 02:40:30,487 --> 02:40:32,723 TO HAVE DONE BECAUSE MANY OF US 3498 02:40:32,789 --> 02:40:33,757 IN THE AUDIENCE ARE EXPERIENCING 3499 02:40:33,824 --> 02:40:37,160 WHATEVER END ORGAN WE MIGHT BE 3500 02:40:37,227 --> 02:40:40,230 LACKING AT AT THE SAME KIND OF 3501 02:40:40,297 --> 02:40:40,430 THING. 3502 02:40:40,497 --> 02:40:44,801 I'M A SIMPLE BONE HEAD SO WHAT 3503 02:40:44,868 --> 02:40:47,504 SHOULD WE BE DOING? 3504 02:40:47,571 --> 02:40:53,310 SHOULD WE BE BOTHERING TO BREED 3505 02:40:53,377 --> 02:40:58,515 THESE MICE BUT I THINK THERE'S 3506 02:40:58,582 --> 02:41:00,584 ISSUES ON JAX AS WELL AND 3507 02:41:00,650 --> 02:41:02,586 CURIOUS WHAT ANYONE THINKS OR 3508 02:41:02,652 --> 02:41:05,856 SHOULD WE JUST KEEP ADDING TO 3509 02:41:05,922 --> 02:41:07,858 THE DIVERSITY AND PHENOTYPIC 3510 02:41:07,924 --> 02:41:11,828 VARIATION FROM TEXAS TO WHEREVER 3511 02:41:11,895 --> 02:41:22,372 THE HELL ELSE THE MICE ARE. 3512 02:41:24,174 --> 02:41:26,510 >> IT BRINGS UP ANOTHER ISSUE 3513 02:41:26,576 --> 02:41:27,778 THAT OUR SAMPLE SIZE HAS TO BE 3514 02:41:27,844 --> 02:41:29,579 LARGE ENOUGH TO DETECT THESE 3515 02:41:29,646 --> 02:41:30,313 TYPES OF VARIATION. 3516 02:41:30,380 --> 02:41:32,416 WHEN I SEE SAMPLE SIZE OF THREE 3517 02:41:32,482 --> 02:41:40,157 AND FOUR I CRINGE. 3518 02:41:40,223 --> 02:41:41,525 THERE'S VARIABILITY. 3519 02:41:41,591 --> 02:41:42,592 >> IT'S RELATED TO THE SIZE OF 3520 02:41:42,659 --> 02:41:43,627 THE DIFFERENCE, RIGHT? 3521 02:41:43,693 --> 02:41:52,069 >> THAT'S RIGHT. 3522 02:41:52,135 --> 02:41:53,970 AND DO WE HAVE ENOUGH POWER TO 3523 02:41:54,037 --> 02:41:55,072 DETECT THE DIFFERENCE AND HAVE 3524 02:41:55,138 --> 02:41:57,441 TO BE CAREFUL WHAT WE'RE DOING 3525 02:41:57,507 --> 02:41:57,874 THERE. 3526 02:41:57,941 --> 02:41:59,776 NOT WITHSTANDING THE OTHER 3527 02:41:59,843 --> 02:42:02,479 ISSUES WITH YOU CAN HAVE 20 OF 3528 02:42:02,546 --> 02:42:05,449 THE TC MAC 21 MOUSE THAT NOW 3529 02:42:05,515 --> 02:42:07,384 YOU'RE GETTING FROM JACKSON MAY 3530 02:42:07,451 --> 02:42:10,587 BE DIFFERENT FROM THE ONES THEY 3531 02:42:10,654 --> 02:42:11,288 ORIGINALLY BRED IN JAPAN. 3532 02:42:11,354 --> 02:42:19,262 >> THANK YOU. 3533 02:42:19,329 --> 02:42:21,631 >> HELLO. 3534 02:42:21,698 --> 02:42:27,504 KELLY SULLIVAN THE SERNIC 3535 02:42:27,571 --> 02:42:27,771 INSTITUTE. 3536 02:42:27,838 --> 02:42:29,773 THANK YOU FOR THE EXPERIMENTAL 3537 02:42:29,840 --> 02:42:31,741 CONDITIONS BUT GIVEN THE 3538 02:42:31,808 --> 02:42:33,510 INTEREST IN THE TC MAC 21 3539 02:42:33,577 --> 02:42:37,481 WONDERING WHAT YOU THINK OF THE 3540 02:42:37,547 --> 02:42:41,284 TRISOMIC UTERINE DEVELOPMENT IN 3541 02:42:41,351 --> 02:42:49,392 EARLY DEVELOPMENTAL PHENOTYPES? 3542 02:42:49,459 --> 02:42:53,697 >> I TRY NOT TO THINK ABOUT IT 3543 02:42:53,763 --> 02:42:54,664 AT ALL. 3544 02:42:54,731 --> 02:42:56,199 IT'S A BIG FACTOR AND SOMETHING 3545 02:42:56,266 --> 02:42:56,933 WE HAVE TO KEEP IN THE 3546 02:42:57,000 --> 02:43:00,370 BACKGROUND AS A FEATURE OF HOW 3547 02:43:00,437 --> 02:43:05,842 RELEVANT WHAT WE'RE DOING 3548 02:43:05,909 --> 02:43:08,345 ACTUALLY IS FOR PEOPLE THAT DID 3549 02:43:08,411 --> 02:43:11,982 NOT DEVELOP TRISOMIC. 3550 02:43:12,048 --> 02:43:12,582 GOOD POINT. 3551 02:43:12,649 --> 02:43:14,417 >> I THINK IT ALSO DEPENDS ON 3552 02:43:14,484 --> 02:43:15,519 WHAT PHENOTYPE YOU'RE LOOKING 3553 02:43:15,585 --> 02:43:16,153 AT. 3554 02:43:16,219 --> 02:43:22,959 WE LOOKED AT SIZE OF EMBRYOS AND 3555 02:43:23,026 --> 02:43:26,463 SHOWED THE UTERINE ENVIRONMENT 3556 02:43:26,530 --> 02:43:29,633 DIDN'T HAVE A DIFFERENT 3557 02:43:29,699 --> 02:43:33,503 INFLUENCE BUT THAT WAS SAMPLING 3558 02:43:33,570 --> 02:43:37,174 A SIMPLE PHENOTYPE. 3559 02:43:37,240 --> 02:43:42,946 >> I JUST WANTED TO MENTION THAT 3560 02:43:43,013 --> 02:43:49,819 WE RECEIVED SOME DIRECTLY FROM 3561 02:43:49,886 --> 02:43:51,955 JAPAN SO THE MICE WE RECEIVED 3562 02:43:52,022 --> 02:43:52,689 MAY BE THE ORIGINAL. 3563 02:43:52,756 --> 02:43:55,091 IT'S A LONG STORY. 3564 02:43:55,158 --> 02:43:57,561 WE PUT XIST INTO THOSE AND THE 3565 02:43:57,627 --> 02:43:59,262 ONES WE DID PUT IT INTO ARE 3566 02:43:59,329 --> 02:44:00,931 STILL BREEDING. 3567 02:44:00,997 --> 02:44:06,436 THE OTHERS STARTED HAVING 3568 02:44:06,503 --> 02:44:09,372 TROUBLE BREEDING BUT WE'VE HAD 3569 02:44:09,439 --> 02:44:12,209 TO FREEZE SOME AND HAD TO 3570 02:44:12,275 --> 02:44:14,277 RECONSTITUTE IN CASE THAT'S 3571 02:44:14,344 --> 02:44:15,011 HELPFUL TO ANYONE. 3572 02:44:15,078 --> 02:44:17,414 AND SORRY TO PUSH THE IDEA BUT I 3573 02:44:17,480 --> 02:44:18,715 WISH SOMEBODY ELSE WOULD HELP DO 3574 02:44:18,782 --> 02:44:18,982 IT. 3575 02:44:19,049 --> 02:44:21,284 IF YOU HAD THE ABILITY TO 3576 02:44:21,351 --> 02:44:23,153 SILENCE THE CHROMOSOME MAYBE 3577 02:44:23,220 --> 02:44:27,958 EVEN INDUCIBLY IN THE SAME MOUSE 3578 02:44:28,024 --> 02:44:30,093 MODEL, THEN YOU WOULD KNOW THAT 3579 02:44:30,160 --> 02:44:33,530 WHATEVER CHANGE YOU SAW WAS DUE 3580 02:44:33,597 --> 02:44:35,632 TO THE CHROMOSOME AND IF ANYONE 3581 02:44:35,699 --> 02:44:38,602 WANTS TO TRY THAT, I'LL HELP 3582 02:44:38,668 --> 02:44:41,171 THEM. 3583 02:44:41,238 --> 02:44:43,740 >> I SECOND THAT. 3584 02:44:43,807 --> 02:44:50,847 I THINK THAT'S AN EXCELLENT 3585 02:44:50,914 --> 02:44:51,147 SUGGESTION. 3586 02:44:51,214 --> 02:44:53,950 I'M FROM UNIVERSITY OF CHICAGO 3587 02:44:54,017 --> 02:44:54,618 AND I'VE BEEN A HEART DISEASE 3588 02:44:54,684 --> 02:44:56,419 PERSON FOR DECADES AND THE 3589 02:44:56,486 --> 02:45:02,225 STRUCK BY THE VARIABILITY IN THE 3590 02:45:02,292 --> 02:45:03,994 LITERATURE OF PEOPLE REPORTING 3591 02:45:04,060 --> 02:45:06,062 THE SAME WITH DIFFERENT 3592 02:45:06,129 --> 02:45:06,596 PHENOTYPES AND DIFFERENT 3593 02:45:06,663 --> 02:45:16,906 EXPRESSIVITY. 3594 02:45:17,707 --> 02:45:24,714 WE LIKE TO DO QUALITATIVE 3595 02:45:24,781 --> 02:45:24,948 SCIENCE. 3596 02:45:25,015 --> 02:45:26,416 AND MAYBE DOWN SYNDROME WE NEED 3597 02:45:26,483 --> 02:45:30,553 TO THINK OF AS A SUBTLE CHANGE 3598 02:45:30,620 --> 02:45:31,988 GENETICALLY ONLY 50% INCREASE IN 3599 02:45:32,055 --> 02:45:34,924 THE GENES THAT ARE THERE. 3600 02:45:34,991 --> 02:45:39,462 THIS IS A KNOCKOUT. 3601 02:45:39,529 --> 02:45:41,064 WE SHOULDN'T EXPECT SIMILAR 3602 02:45:41,131 --> 02:45:42,966 PENETRANT OR EXPRESSIVITY AND IF 3603 02:45:43,033 --> 02:45:47,037 WE CHANGE OUR VIEW TO A MORE 3604 02:45:47,103 --> 02:45:50,440 QUANTITATIVE VIEW AND 3605 02:45:50,507 --> 02:45:55,011 COMMUNICATE MORE OPENLY ACROSS 3606 02:45:55,078 --> 02:45:56,946 BOUNDARIES TO ASSESS MODELS BY 3607 02:45:57,013 --> 02:45:58,515 MULTIPLE GROUPS MAYBE WE CAN 3608 02:45:58,581 --> 02:46:02,385 CORRECT SOME PROBLEMS IN THE AND 3609 02:46:02,452 --> 02:46:12,462 STOP PUBLISHING VARIABILITY. 3610 02:46:12,529 --> 02:46:18,134 >> I'M FROM PAKISTAN AND THIS IS 3611 02:46:18,201 --> 02:46:19,869 MY SERVICE VISIT TO NIH SO I'M 3612 02:46:19,936 --> 02:46:24,674 EXCITED TO BE PART OF THE 3613 02:46:24,741 --> 02:46:25,208 CONFERENCE. 3614 02:46:25,275 --> 02:46:30,580 FIRST, I THINK I ENJOY THE 3615 02:46:30,647 --> 02:46:32,682 SESSIONS FROM THIS MORNING AND 3616 02:46:32,749 --> 02:46:34,517 MY QUESTION IS FROM TIFFANY. 3617 02:46:34,584 --> 02:46:37,087 THANK YOU FOR HIGHLIGHTING THE 3618 02:46:37,153 --> 02:46:39,422 BIO MEDICAL MODEL VERSUS THE 3619 02:46:39,489 --> 02:46:41,057 SOCIAL DETERMINATES OF HEALTH 3620 02:46:41,124 --> 02:46:44,594 MODEL AND COMING FROM PAKISTAN 3621 02:46:44,661 --> 02:46:46,763 WHERE THE RESOURCES ARE STRAINED 3622 02:46:46,830 --> 02:46:49,699 AND THE DISEASE BURDEN OF DOWN 3623 02:46:49,766 --> 02:46:51,301 SYNDROME IS HUGE AND THERE'S 3624 02:46:51,368 --> 02:46:52,135 DEVELOPMENTAL GOALS. 3625 02:46:52,202 --> 02:46:58,441 WE ALL AIM FOR ATTAINING IT BY 3626 02:46:58,508 --> 02:47:00,710 2030 OR SO AND WE'RE FACING 3627 02:47:00,777 --> 02:47:02,078 STRUGGLES AND CHALLENGES. 3628 02:47:02,145 --> 02:47:07,150 SO WHEN WE TALK ABOUT DOWN 3629 02:47:07,217 --> 02:47:10,587 SYNDROME AND I'M HEARING 3630 02:47:10,653 --> 02:47:13,189 RESEARCH FOR DOWN SYNDROME AND 3631 02:47:13,256 --> 02:47:15,725 HOW DO WE FORESEE INCLUSIVENESS 3632 02:47:15,792 --> 02:47:18,661 OF DOWN SYNDROME FROM THE LMICs 3633 02:47:18,728 --> 02:47:20,196 AND FROM THE RESEARCH SPECTRUM 3634 02:47:20,263 --> 02:47:22,565 WHERE WE HAVE LIMITED RESOURCES 3635 02:47:22,632 --> 02:47:23,633 FOR RESEARCH AND CONSIDERING WE 3636 02:47:23,700 --> 02:47:26,035 HAVE OF COURSE LIMITED RESOURCES 3637 02:47:26,102 --> 02:47:27,604 BUT TO A CERTAIN EXTENT WE DO 3638 02:47:27,670 --> 02:47:28,571 HAVE AT NIH. 3639 02:47:28,638 --> 02:47:31,541 HOW DO WE FORCE INCLUSIVENESS OF 3640 02:47:31,608 --> 02:47:33,977 DOWN SYNDROME FROM THAT PART OF 3641 02:47:34,043 --> 02:47:36,279 THE WORLD WHERE WE CAN 3642 02:47:36,346 --> 02:47:38,114 CONTRIBUTE TO ONE-THIRD OF THE 3643 02:47:38,181 --> 02:47:39,382 WORLD'S POPULATION. 3644 02:47:39,449 --> 02:47:42,619 >> THANK YOU FOR THAT QUESTION. 3645 02:47:42,685 --> 02:47:45,221 IT'S A BIG, BIG, BIG, QUESTION. 3646 02:47:45,288 --> 02:47:49,759 AND THE COMPLEXITY OF ENGAGING 3647 02:47:49,826 --> 02:47:52,061 WITH ALL OF THE DIFFERENCES AND 3648 02:47:52,128 --> 02:47:54,330 THE TYPES OF RESOURCES AVAILABLE 3649 02:47:54,397 --> 02:47:57,467 TO SUPPORT DIFFERENT INDIVIDUALS 3650 02:47:57,534 --> 02:48:01,004 AROUND THE WORLD, IT'S A 3651 02:48:01,070 --> 02:48:01,438 STAGGERING PROBLEM. 3652 02:48:01,504 --> 02:48:07,076 I DON'T HAVE IDEAS ABOUT 3653 02:48:07,143 --> 02:48:12,682 SOLUTIONS BUT I THINK WHAT WE 3654 02:48:12,749 --> 02:48:15,518 WOULD LIKE TO SEE IS MAKING SURE 3655 02:48:15,585 --> 02:48:17,754 INPUT FROM ALL THE STAKEHOLDERS 3656 02:48:17,821 --> 02:48:20,890 ACROSS THE WORLD AND THE 3657 02:48:20,957 --> 02:48:21,891 DIFFERENT CIRCUMSTANCES IS 3658 02:48:21,958 --> 02:48:22,625 ACCESSED AND TAKEN INTO 3659 02:48:22,692 --> 02:48:23,893 CONSIDERATION. 3660 02:48:23,960 --> 02:48:26,763 I THINK THE THING THAT WORRIES 3661 02:48:26,830 --> 02:48:30,300 ME A LOT IS FOR THE INDIVIDUALS 3662 02:48:30,366 --> 02:48:36,139 WHO HAVE THE LEAST ACCESS TO 3663 02:48:36,206 --> 02:48:37,807 RESOURCES AND MAYBE TO THE 3664 02:48:37,874 --> 02:48:39,642 HIGHEST SUPPORT NEEDS MAY HAVE 3665 02:48:39,709 --> 02:48:41,678 THE FEWEST OPPORTUNITIES TO 3666 02:48:41,744 --> 02:48:44,647 CONTRIBUTE THEIR VOICE TO THE 3667 02:48:44,714 --> 02:48:45,482 CONVERSATIONS ABOUT WHAT SHOULD 3668 02:48:45,548 --> 02:48:47,951 BE RESEARCH PRIORITIES AND HOW 3669 02:48:48,017 --> 02:48:49,786 DO WE IDENTIFY FUNCTION LEVELS 3670 02:48:49,853 --> 02:48:53,323 WHEN WE'RE WANTING TO INCLUDE 3671 02:48:53,389 --> 02:48:55,358 INDIVIDUALS WHO COME FROM SO 3672 02:48:55,425 --> 02:48:57,427 MANY LIFE EXPERIENCES WITH SO 3673 02:48:57,494 --> 02:48:59,596 MANY LEVELS OF SUPPORT THAT WILL 3674 02:48:59,662 --> 02:49:01,030 ULTIMATELY IMPACT HOW PEOPLE 3675 02:49:01,097 --> 02:49:02,599 PERCEIVE THEIR FUNCTIONING 3676 02:49:02,665 --> 02:49:08,271 LEVELS? 3677 02:49:08,338 --> 02:49:09,272 IT'S A BIG CONVERSATION AND I 3678 02:49:09,339 --> 02:49:11,174 LOOK FORWARD FOR THE COMMUNITY 3679 02:49:11,241 --> 02:49:14,611 TO CONTINUE TALKING ABOUT THIS 3680 02:49:14,677 --> 02:49:17,647 IN THE COMING YEARS. 3681 02:49:17,714 --> 02:49:20,783 >> GREAT TALKED. 3682 02:49:20,850 --> 02:49:25,054 I'M FROM NYU SCHOOL OF MEDICINE. 3683 02:49:25,121 --> 02:49:27,457 MICE SHOULD ALL BE BRED BACK TO 3684 02:49:27,524 --> 02:49:33,296 A BLACK 6 TO KEEP IT ISO GENIC 3685 02:49:33,363 --> 02:49:35,832 AND DIVERSITY ISN'T BAD AND 3686 02:49:35,899 --> 02:49:37,100 HUMANS ARE DIVERSE. 3687 02:49:37,166 --> 02:49:39,869 SHOULDN'T WE TRY TO MAP THE 3688 02:49:39,936 --> 02:49:45,074 MODIFIERS BETWEEN THE DIVERGENT 3689 02:49:45,141 --> 02:49:50,914 THINGS THAT ARE HELPFUL AND 3690 02:49:50,980 --> 02:49:51,915 STRAINS AND IT'S AN OPPORTUNITY 3691 02:49:51,981 --> 02:49:53,049 TO LOOK AT THE MODIFIERS? 3692 02:49:53,116 --> 02:49:56,519 >> I THINK THE FIRST THING WE 3693 02:49:56,586 --> 02:50:00,456 HAVE TO THINK ABOUT IS NOT ALL 3694 02:50:00,523 --> 02:50:04,727 THESE MICE ARE ON AN INBRED 3695 02:50:04,794 --> 02:50:06,963 BACKGROUND AND IT OFFERS 3696 02:50:07,030 --> 02:50:07,864 ADVANTAGES AND DISADVANTAGES. 3697 02:50:07,931 --> 02:50:09,265 LIKE WE SAID BEFORE WE NEED TO 3698 02:50:09,332 --> 02:50:14,203 THINK ABOUT THIS MORE AS A 3699 02:50:14,270 --> 02:50:17,507 QUANTITATIVE TRAIT THAT IS NOT 3700 02:50:17,574 --> 02:50:18,608 PRESENT OR ABSENCE AND I THINK 3701 02:50:18,675 --> 02:50:20,376 WHEN YOU START LOOKING AT THAT 3702 02:50:20,443 --> 02:50:22,045 AND START THINKING ABOUT WHAT 3703 02:50:22,111 --> 02:50:25,348 ARE THE MODIFIER GENES ON THE 3704 02:50:25,415 --> 02:50:25,982 CHROMOSOME AS WELL AS DIFFERENT 3705 02:50:26,049 --> 02:50:28,151 CHROMOSOMES. 3706 02:50:28,217 --> 02:50:31,321 >> I WOULD LIKE TO ADD FIRST 3707 02:50:31,387 --> 02:50:33,156 THAT I THINK JAX IS AMAZING. 3708 02:50:33,222 --> 02:50:35,725 I THINK WHAT THEY DO IS 3709 02:50:35,792 --> 02:50:37,293 DIFFICULT AND I THINK THEY 3710 02:50:37,360 --> 02:50:41,698 EXPERIENCE MANY OF THE 3711 02:50:41,764 --> 02:50:43,232 CHALLENGES THAT WE DO AND TRYING 3712 02:50:43,299 --> 02:50:47,236 TO DO IT IN A CONTROLLED WAY AND 3713 02:50:47,303 --> 02:50:52,041 WANTED TO PUT THAT OUT THERE. 3714 02:50:52,108 --> 02:50:54,177 IN TERMS OF THE VARIABILITY, 3715 02:50:54,243 --> 02:50:56,179 IT'S A DOUBLE-EDGED SWORD. 3716 02:50:56,245 --> 02:50:57,780 IT'S GREAT FOR WET LAB SCIENTIST 3717 02:50:57,847 --> 02:51:02,585 TO STUDY SOMETHING CONSTANT OVER 3718 02:51:02,652 --> 02:51:04,153 TIME AND DEVELOP A QUANTITATIVE 3719 02:51:04,220 --> 02:51:04,587 INFORMATION OF IT. 3720 02:51:04,654 --> 02:51:10,226 THE FACT THAT MANY OF OUR MODELS 3721 02:51:10,293 --> 02:51:20,770 ARE NOT THAT ARE THAT'S AN 3722 02:51:29,012 --> 02:51:29,278 IMPORTANT FEATURE. 3723 02:51:29,345 --> 02:51:31,614 WE NEED TO BE ABLE TO DO OUR 3724 02:51:31,681 --> 02:51:36,519 WORK CAREFULLY ENOUGH SO WE CAN 3725 02:51:36,586 --> 02:51:41,824 DO THAT WELL. 3726 02:51:41,891 --> 02:51:48,498 >> I'M THERE THE JACKSON LAB, 3727 02:51:48,564 --> 02:51:50,600 CHING RALPH -- 3728 02:51:50,667 --> 02:51:50,867 [APPLAUSE] 3729 02:51:50,933 --> 02:51:51,968 BUT I HAVE NOTHING TO DO WITH 3730 02:51:52,035 --> 02:51:56,773 THE PRODUCTICTION OF THE MICE WE 3731 02:51:56,839 --> 02:51:57,206 TALKING ABOUT. 3732 02:51:57,273 --> 02:51:58,341 >> DID I SAY IT RIGHT. 3733 02:51:58,408 --> 02:52:00,443 >> I'LL BRING THIS BACK. 3734 02:52:00,510 --> 02:52:07,016 I'M ACTUALLY A PEDIATRIC 3735 02:52:07,083 --> 02:52:08,885 ONCOLOGIST STUDYING TAM IN DOWN 3736 02:52:08,951 --> 02:52:09,152 SYNDROME. 3737 02:52:09,218 --> 02:52:11,988 I HAVE A QUESTION FOR THE PANEL. 3738 02:52:12,055 --> 02:52:15,625 IS THERE EXISTING DATA COMPARING 3739 02:52:15,692 --> 02:52:19,796 THE HEMATOLOGIC PROFILE OF THE 3740 02:52:19,862 --> 02:52:21,664 MOUSE MODELS FOR DOWN SYNDROME? 3741 02:52:21,731 --> 02:52:22,965 BECAUSE THAT MAY BE VERY 3742 02:52:23,032 --> 02:52:24,500 CRITICAL FOR US TO USE THEM AS A 3743 02:52:24,567 --> 02:52:34,210 STARTING POINT TO STUDY TAM. 3744 02:52:34,277 --> 02:52:37,747 >> WE'VE RECENTLY SHOWN HE MATIC 3745 02:52:37,814 --> 02:52:39,649 CONCENTRATIONS ARE LOWER AND WE 3746 02:52:39,716 --> 02:52:41,884 FOLLOWED THAT UP IN A POPULATION 3747 02:52:41,951 --> 02:52:44,854 MEDICAL RECORD REVIEW AND FOUND 3748 02:52:44,921 --> 02:52:47,423 ANEMIA IS ALSO VERY COMMON IN 3749 02:52:47,490 --> 02:52:49,859 INDIVIDUALS WITH DOWN SYNDROME 3750 02:52:49,926 --> 02:52:54,630 BUT WE HAVE SHOWN IT IN MT65DN 3751 02:52:54,697 --> 02:52:55,531 THE LEVELS ARE LOWER. 3752 02:52:55,598 --> 02:53:01,637 >> WHEN YOU START COMPARING THE 3753 02:53:01,704 --> 02:53:02,772 DIFFERENT DOWN SYNDROME MOUSE 3754 02:53:02,839 --> 02:53:03,673 MODELS, THEY'RE ALWAYS 3755 02:53:03,740 --> 02:53:05,074 GENERATING NEW MODELS. 3756 02:53:05,141 --> 02:53:09,445 THERE'S A COUPLE MODELS WE'RE 3757 02:53:09,512 --> 02:53:11,881 EXCITED ABOUT TC MAC WE'RE 3758 02:53:11,948 --> 02:53:13,449 TRYING TO GENERATE THE DATA AND 3759 02:53:13,516 --> 02:53:14,584 COMPARE THEM WHERE WE HAVE THE 3760 02:53:14,650 --> 02:53:15,017 DATA. 3761 02:53:15,084 --> 02:53:17,854 I THINK WE HAVE BONE PHENOTYPES 3762 02:53:17,920 --> 02:53:19,422 FROM PROBABLY 12 DIFFERENT MOUSE 3763 02:53:19,489 --> 02:53:19,622 MODEL. 3764 02:53:19,689 --> 02:53:22,725 THE STUDY I SHOWED YOU WAS NINE 3765 02:53:22,792 --> 02:53:24,393 DIFFERENT MOUSE MODELS. 3766 02:53:24,460 --> 02:53:25,094 WE'RE STARTING TO MAKE THOSE 3767 02:53:25,161 --> 02:53:26,629 TYPES OF COMPARISONS BETWEEN THE 3768 02:53:26,696 --> 02:53:31,267 MODELS. 3769 02:53:31,334 --> 02:53:41,878 >> JULIE CORNBERG UNIVERSITY OF 3770 02:53:42,979 --> 02:53:43,179 UTAH. 3771 02:53:43,246 --> 02:53:45,014 THANK YOU FOR THE WONDERFUL 3772 02:53:45,081 --> 02:53:45,581 PRESENTATION. 3773 02:53:45,648 --> 02:53:48,718 AS A GENETICIST VARIATION IS OUR 3774 02:53:48,785 --> 02:53:51,287 FRIEND NOT OUR ENEMY AND WE 3775 02:53:51,354 --> 02:53:53,156 EXPLAINED THIS IN TERMS OF 3776 02:53:53,222 --> 02:53:54,624 EXPRESSIVITY AND VARIATION OF 3777 02:53:54,690 --> 02:53:56,092 THINGS. 3778 02:53:56,159 --> 02:53:59,929 IN FACT, I THINK THERE MAY BE 3779 02:53:59,996 --> 02:54:02,064 EQUAL OR GREATER VARIABILITY IN 3780 02:54:02,131 --> 02:54:03,399 HUMANS AND THEREFORE THIS MAKES 3781 02:54:03,466 --> 02:54:06,502 ME FEEL VERY GOOD ABOUT MOUSE 3782 02:54:06,569 --> 02:54:08,204 MODELS TO SEE WE HAVE SUCH 3783 02:54:08,271 --> 02:54:08,471 VARIATION. 3784 02:54:08,538 --> 02:54:11,374 AND I'D LIKE TO KNOW YOUR 3785 02:54:11,440 --> 02:54:13,643 THOUGHTS AND PERHAPS YOU'VE 3786 02:54:13,709 --> 02:54:15,511 ADDRESSED THIS MOST STRIKINGLY. 3787 02:54:15,578 --> 02:54:18,614 HOW CAN WE USE THIS OR 3788 02:54:18,681 --> 02:54:23,419 STANDARDIZE IT OR PROVIDE 3789 02:54:23,486 --> 02:54:25,121 INFORMATION IN PAPERS ABOUT WHAT 3790 02:54:25,188 --> 02:54:28,257 THE TEMPERATURES OR GENDERS AND 3791 02:54:28,324 --> 02:54:29,158 VARIOUS THINGS THAT WERE 3792 02:54:29,225 --> 02:54:30,593 DISCUSSED TO USE VARIATION IN 3793 02:54:30,660 --> 02:54:36,732 THE MOUSE MODELS TO UNDERSTAND 3794 02:54:36,799 --> 02:54:40,203 AND POSE TOWARDS HUMANS. 3795 02:54:40,269 --> 02:54:43,172 >> THANK YOU FOR ALL YOUR KIND 3796 02:54:43,239 --> 02:54:44,140 COMMENTS ABOUT OUR 3797 02:54:44,207 --> 02:54:44,607 PRESENTATIONS. 3798 02:54:44,674 --> 02:54:48,044 YEAH, I THINK FINDING A WAY TO 3799 02:54:48,110 --> 02:54:52,148 STANDARDIZE OR AT LEAST 3800 02:54:52,215 --> 02:54:53,983 STANDARDIZE WHAT IS REPORTED IN 3801 02:54:54,050 --> 02:54:54,550 A METHODS SECTION. 3802 02:54:54,617 --> 02:54:55,985 >> THAT'S THE ISSUE. 3803 02:54:56,052 --> 02:54:57,687 WE'LL NEVER STANDARDIZE, THANK 3804 02:54:57,753 --> 02:54:59,522 GOD. 3805 02:54:59,589 --> 02:55:03,092 >> BUT WHAT IS REPORTED I THINK 3806 02:55:03,159 --> 02:55:04,660 WOULD BE VERY VALUABLE TO THE 3807 02:55:04,727 --> 02:55:06,596 COMMUNITY SO WE COULD COMPARE 3808 02:55:06,662 --> 02:55:10,633 ACROSS GROUPS. 3809 02:55:10,700 --> 02:55:11,601 >> I AGREE. 3810 02:55:11,667 --> 02:55:15,905 I THINK WE NEED TO THINK ABOUT 3811 02:55:15,972 --> 02:55:17,006 PROVIDING AS MUCH DETAIL AS 3812 02:55:17,073 --> 02:55:18,774 POSSIBLE IN OUR PUBLICATIONS 3813 02:55:18,841 --> 02:55:21,310 INCLUDING WHEN WE RECEIVED 3814 02:55:21,377 --> 02:55:24,113 ANIMALS FROM WHOM, HOW MANY 3815 02:55:24,180 --> 02:55:26,816 TIMES THEY WERE BRED, THE 3816 02:55:26,883 --> 02:55:29,952 GENERATION STATUS OF THE ACTUAL 3817 02:55:30,019 --> 02:55:32,655 SAMPLES THAT ARE IN THE GRAPHS. 3818 02:55:32,722 --> 02:55:35,925 WIRE CAGES FOR -- THERE'S SO 3819 02:55:35,992 --> 02:55:39,695 MUCH THAT WE NEED TO I THINK 3820 02:55:39,762 --> 02:55:41,764 ABLE TO CAREFULLY AND COMPLETELY 3821 02:55:41,831 --> 02:55:44,033 DISSEMINATE ALONG WITH THE DATA 3822 02:55:44,100 --> 02:55:45,902 SO THAT BECAUSE ALL OF THAT 3823 02:55:45,968 --> 02:55:49,572 INFORMATION ALTOGETHER WILL BE 3824 02:55:49,639 --> 02:55:50,606 KNEADED TO COMPREHENSIVELY 3825 02:55:50,673 --> 02:55:52,708 REPEAT THOSE STUDIES. 3826 02:55:52,775 --> 02:55:56,812 >> IF I CAN JUST MAKE A COMMENT 3827 02:55:56,879 --> 02:56:01,517 HERE THAT IT'S VERY EXCITING TO 3828 02:56:01,584 --> 02:56:04,654 SEE THAT PERHAPS THE KIND OF 3829 02:56:04,720 --> 02:56:06,355 VARIATION YES, HEART DISEASE, 3830 02:56:06,422 --> 02:56:08,491 NO, HEART DISEASE, SMALL, LARGE, 3831 02:56:08,557 --> 02:56:10,393 WHATEVER IS REALLY -- GIVES A 3832 02:56:10,459 --> 02:56:12,461 GREAT HOPE FOR OUR HUMAN STUDIES 3833 02:56:12,528 --> 02:56:15,331 BECAUSE IT MEANS THAT WITH VERY 3834 02:56:15,398 --> 02:56:16,065 SMALL CHANGES, PERHAPS 3835 02:56:16,132 --> 02:56:20,036 ENVIRONMENTAL IN SOME CASES, WE 3836 02:56:20,102 --> 02:56:25,408 MAY BE ABLE TO PREVENT, TREAT, 3837 02:56:25,474 --> 02:56:27,410 ETCETERA HUMANS INSTEAD OF THINK 3838 02:56:27,476 --> 02:56:30,947 OH, MY GOD THERE'S A GENE 80% X. 3839 02:56:31,013 --> 02:56:32,515 I THINK IT'S VERY IMPORTANT WE 3840 02:56:32,581 --> 02:56:34,951 UNDERSTAND THESE KINDS OF THINGS 3841 02:56:35,017 --> 02:56:36,919 IN THE MOUSE AND PERHAPS TRY TO 3842 02:56:36,986 --> 02:56:37,553 UNDERSTAND THEM A LITTLE BIT IN 3843 02:56:37,620 --> 02:56:47,463 HUMANS. 3844 02:56:47,530 --> 02:56:50,633 >> I'M HAVE THE UNIVERSITY OF 3845 02:56:50,700 --> 02:56:51,567 TEXAS SOUTHWESTERN MEDICAL 3846 02:56:51,634 --> 02:56:51,867 CENTER. 3847 02:56:51,934 --> 02:57:02,478 I'M HERE TO CONFESS MY SINS AND 3848 02:57:04,680 --> 02:57:10,219 I'M TRYING TRYING -- TO LOOK AT 3849 02:57:10,286 --> 02:57:13,055 F1s AND WONDERING WHAT YOU THINK 3850 02:57:13,122 --> 02:57:14,323 ABOUT THAT. 3851 02:57:14,390 --> 02:57:17,226 >> I THINK IT CERTAINLY HAS 3852 02:57:17,293 --> 02:57:18,160 MERIT AS LONG AS YOU'RE TRACKING 3853 02:57:18,227 --> 02:57:28,904 THE VARIABILITY YOUR E INTRO 3854 02:57:30,306 --> 02:57:34,610 INTRODUCING AND WOULD MORE 3855 02:57:34,677 --> 02:57:36,645 CLOSELY MODEL THE SYSTEM AND HOW 3856 02:57:36,712 --> 02:57:39,281 MANY MICE YOU'D NEED TO SEE THE 3857 02:57:39,348 --> 02:57:40,583 PHENOTYPE -- 3858 02:57:40,649 --> 02:57:44,653 >> WE WERE CONCERNED INITIALLY. 3859 02:57:44,720 --> 02:57:46,655 AS LONG AS WE'RE MAINTAINING THE 3860 02:57:46,722 --> 02:57:46,922 DP16. 3861 02:57:46,989 --> 02:57:50,626 WE MAINTAIN THOSE AS RELATIVELY 3862 02:57:50,693 --> 02:57:54,630 DP16 PURISH AND MAKE THEM TO A 3863 02:57:54,697 --> 02:57:58,300 CD 1 AND LOOK AT THOSE 3864 02:57:58,367 --> 02:57:59,301 PHENOTYPES AND STILL MAINTAINED 3865 02:57:59,368 --> 02:57:59,568 PHENOTYPE. 3866 02:57:59,635 --> 02:58:07,543 JUST THROWING IT OUT THERE. 3867 02:58:07,610 --> 02:58:10,613 >> THANK YOU FOR THE PANEL. 3868 02:58:10,679 --> 02:58:12,982 I'M CONTINUING ON THE THEME OF 3869 02:58:13,049 --> 02:58:15,751 DIVERSITY ACTUALLY BEING A GOOD 3870 02:58:15,818 --> 02:58:18,921 THING. 3871 02:58:18,988 --> 02:58:21,090 I WANT TO PUT A NOTE OF OPTIMISM 3872 02:58:21,157 --> 02:58:23,459 HERE AND THERE'S SOME PHENOTYPES 3873 02:58:23,526 --> 02:58:28,898 VERY REPRODUCIBLE. 3874 02:58:28,964 --> 02:58:30,866 DP16 MICE HAVE COGNITIVE 3875 02:58:30,933 --> 02:58:31,133 DEFICITS. 3876 02:58:31,200 --> 02:58:38,007 HALF OF THOSE HAVE ISSUES AND 3877 02:58:38,074 --> 02:58:40,009 THERE'S VARIABILITY BUT I THINK 3878 02:58:40,076 --> 02:58:42,011 WE CAN AGREE ON CORE PHENOTYPES 3879 02:58:42,078 --> 02:58:43,712 OF RELEVANCE TO THE HUMAN 3880 02:58:43,779 --> 02:58:44,947 CONDITION THAT ARE SEEN TIME AND 3881 02:58:45,014 --> 02:58:46,515 TIME AGAIN. 3882 02:58:46,582 --> 02:58:48,284 START FROM THAT POINT WHAT DO 3883 02:58:48,350 --> 02:58:54,323 YOU THINK SHOULD BE THE KEY BIG 3884 02:58:54,390 --> 02:58:58,761 VARIABLES WE SHOULD TRY TO MODEL 3885 02:58:58,828 --> 02:59:06,001 IN THE LAB AND LOOKING AT A MORE 3886 02:59:06,068 --> 02:59:06,969 SOCIAL ENVIRONMENT. 3887 02:59:07,036 --> 02:59:09,805 IS THAT THE FIRST THING WE NEED 3888 02:59:09,872 --> 02:59:10,840 TO UNDERSTAND AND SOMETHING THAT 3889 02:59:10,906 --> 02:59:20,349 COMES TO MIND IS DIET. 3890 02:59:20,416 --> 02:59:21,417 PEOPLE WITH DOWN SYNDROME DON'T 3891 02:59:21,484 --> 02:59:23,919 EAT THE BIG MACS. 3892 02:59:23,986 --> 02:59:27,089 AND WHAT OTHER VARIABLES SHOULD 3893 02:59:27,156 --> 02:59:30,626 WE TRY TO BRING IN IN A 3894 02:59:30,693 --> 02:59:33,496 SYSTEMATIC FASHION TO UNDERSTAND 3895 02:59:33,562 --> 02:59:33,996 THE IMPACT ON THE CORE 3896 02:59:34,063 --> 02:59:38,434 PHENOTYPES. 3897 02:59:38,501 --> 02:59:41,804 IF YOU ASK ME I'LL SAY WE NEED 3898 02:59:41,871 --> 02:59:44,974 TO TRACE THE MICE WITH REAL LIFE 3899 02:59:45,040 --> 02:59:45,241 PATHOGENS. 3900 02:59:45,307 --> 02:59:46,942 I WANT TO HEAR YOUR IDEAS. 3901 02:59:47,009 --> 02:59:51,380 >> SO AS A GENETICIST MOST 3902 02:59:51,447 --> 02:59:54,617 PEOPLE WITH DOWN SYNDROME HAVE 3903 02:59:54,683 --> 03:00:00,956 AN EXTRA CENTROMERE. 3904 03:00:01,023 --> 03:00:02,324 THERE'S ONE VARIABLE WE HAVE AND 3905 03:00:02,391 --> 03:00:06,595 THERE'S WORK THAT SHOWS THERE'S 3906 03:00:06,662 --> 03:00:08,130 AN EFFECT OF THAT. 3907 03:00:08,197 --> 03:00:12,835 SO AND MY COLLEAGUES HERE HAVE 3908 03:00:12,902 --> 03:00:14,837 INSIGHT IN THE ENVIRONMENTAL 3909 03:00:14,904 --> 03:00:15,070 EFFECTS. 3910 03:00:15,137 --> 03:00:18,641 >> WE START WITH THE ARRIVE 3911 03:00:18,707 --> 03:00:25,614 GUIDELINES, I THINK ACRONYM 3912 03:00:25,681 --> 03:00:26,248 A-V-R-E AND REPORT TIME OF DAY 3913 03:00:26,315 --> 03:00:36,659 IN OUR EXPERIMENTS. 3914 03:00:37,993 --> 03:00:42,164 I FEEL DIET WOULD HAVE A HUGE 3915 03:00:42,231 --> 03:00:44,266 IMPACT OF THE COMPOSITION OF THE 3916 03:00:44,333 --> 03:00:48,938 DIET AND TEXTUAL ASPECTS OF THE 3917 03:00:49,004 --> 03:00:58,447 FOOD PELLET AND TEMPERATURE AND 3918 03:00:58,514 --> 03:00:59,882 HOUSING AND SOMETIMES MICE CAN 3919 03:00:59,949 --> 03:01:01,183 BE CO-HOUSED AND SOMETIMES NEED 3920 03:01:01,250 --> 03:01:03,652 TO BE SINGLY HOUSED. 3921 03:01:03,719 --> 03:01:04,987 ISSUES LIKE SOCIAL STRESS SEEM 3922 03:01:05,054 --> 03:01:09,558 TO HAVE A HUGE IMPACT ON 3923 03:01:09,625 --> 03:01:11,827 OUTCOMES FOR THE TS65DN AS THEY 3924 03:01:11,894 --> 03:01:16,832 START TO AGE AND GET VERY OLD. 3925 03:01:16,899 --> 03:01:21,670 SOCIAL STRESS CAN IMPACT THEM 3926 03:01:21,737 --> 03:01:24,773 HEAVILY TO KNOW WHAT OTHER -- 3927 03:01:24,840 --> 03:01:27,643 >> I AGREE WITH TO THE HOUSING 3928 03:01:27,710 --> 03:01:27,910 CONCERNS. 3929 03:01:27,977 --> 03:01:29,044 ANY WAY TO REPORT WHAT WE CAN DO 3930 03:01:29,111 --> 03:01:31,747 IN OUR STUDIES TO COMPARE ACROSS 3931 03:01:31,814 --> 03:01:32,881 GROUPS IS HELPFUL. 3932 03:01:32,948 --> 03:01:35,618 WE FIND THE SAME THING WITH 3933 03:01:35,684 --> 03:01:38,587 AGING TO65DN AS THEY GET OLDER 3934 03:01:38,654 --> 03:01:42,591 THE SOCIAL STRESS SEEMS TO BE 3935 03:01:42,658 --> 03:01:44,460 MORE PROBLEMATIC. 3936 03:01:44,526 --> 03:01:46,595 WE SEPARATE THEM AT THE END 3937 03:01:46,662 --> 03:01:48,831 POINT HOW DOES THAT INTRODUCING 3938 03:01:48,897 --> 03:01:50,599 VARIABILITY BUT THERE'S SOME 3939 03:01:50,666 --> 03:01:52,534 THINGS YOU CAN'T CHANGE. 3940 03:01:52,601 --> 03:01:54,370 IF YOU'RE AT AN FACILITY WITH 3941 03:01:54,436 --> 03:01:57,106 IVE SYSTEM YOU CAN'T GO TO A 3942 03:01:57,172 --> 03:01:58,807 WERE TOP CAGING SYSTEM AN 3943 03:01:58,874 --> 03:02:01,343 THERE'S SOME ISSUES OUTSIDE OF 3944 03:02:01,410 --> 03:02:02,745 OUR CONTROL IN CERTAIN 3945 03:02:02,811 --> 03:02:03,045 SCENARIOS. 3946 03:02:03,112 --> 03:02:05,614 THERE'S A LOT TO CONSIDER AND AS 3947 03:02:05,681 --> 03:02:07,750 A COMMUNITY WE CAN THINK ABOUT 3948 03:02:07,816 --> 03:02:10,319 SOME THINGS THAT ARE THE MOST 3949 03:02:10,386 --> 03:02:15,124 IMPORTANT AND I'LL ECHO THE DIET 3950 03:02:15,190 --> 03:02:17,259 CONCERNS AND TALK ABOUT IN UTERO 3951 03:02:17,326 --> 03:02:21,363 AND WHEN DOES A NEW DIET GET 3952 03:02:21,430 --> 03:02:21,697 INTRODUCED. 3953 03:02:21,764 --> 03:02:23,399 THERE'S ALL KINDS OF DIETS THAT 3954 03:02:23,465 --> 03:02:27,503 CAN INFLUENCE OUTCOMES AND THE 3955 03:02:27,569 --> 03:02:30,773 TYPICAL CHOW DIET IS LOW FAT NOT 3956 03:02:30,839 --> 03:02:32,908 NECESSARILY DIRECTLY COMPARABLE 3957 03:02:32,975 --> 03:02:33,842 TO HUMAN DIET. 3958 03:02:33,909 --> 03:02:41,617 AT LEAST AN AMERICAN DIET. 3959 03:02:41,684 --> 03:02:42,885 >> WE'LL HAVE TO BRING THE PANEL 3960 03:02:42,951 --> 03:02:44,753 TO A CLOSE AND APOLOGY FOR THE 3961 03:02:44,820 --> 03:02:46,689 QUESTIONS WE DIDN'T HAVE TIME TO 3962 03:02:46,755 --> 03:02:46,989 ADDRESS. 3963 03:02:47,056 --> 03:02:55,531 THE NEXT ITEM IN OUR AGENDA IS 3964 03:02:55,597 --> 03:03:03,672 TO INTRODUCE THE BREAKOUT 3965 03:03:03,739 --> 03:03:12,881 SESSIONS. 3966 03:03:12,948 --> 03:03:16,585 >> MY NAME IS MEGAN O'NEAL. 3967 03:03:16,652 --> 03:03:18,187 I'M A NEW PROGRAM OFFICER, 3968 03:03:18,253 --> 03:03:23,592 MEDICAL OFFICER FOR THE INCLUDE 3969 03:03:23,659 --> 03:03:26,128 PROJECT. 3970 03:03:26,195 --> 03:03:27,229 FOR THE DEVELOPMENT AND 3971 03:03:27,296 --> 03:03:27,930 DISABILITIES BRANCH. 3972 03:03:27,996 --> 03:03:31,367 I'M TRAINED AS A NEURAL 3973 03:03:31,433 --> 03:03:32,134 DEVELOPMENTAL PHYSICIAN AND 3974 03:03:32,201 --> 03:03:33,001 CHILD NEUROLOGIST. 3975 03:03:33,068 --> 03:03:34,603 I PROMISE NOT TO KEEP YOU TOO 3976 03:03:34,670 --> 03:03:36,205 MANY LONGER FROM YOUR LUNCH. 3977 03:03:36,271 --> 03:03:44,613 I'LL TALK BRIEFLY ABOUT BRINGING 3978 03:03:44,680 --> 03:03:48,417 ALL TOGETHER WITH BREAKOUT 3979 03:03:48,484 --> 03:03:50,452 SESSIONS HAPPENING DURING LUNCH 3980 03:03:50,519 --> 03:03:50,719 TODAY. 3981 03:03:50,786 --> 03:03:51,854 TODAY WE HEARD ABOUT THE 3982 03:03:51,920 --> 03:03:52,421 DIFFERENT COMPONENTS OF THE 3983 03:03:52,488 --> 03:04:02,765 INCLUDE PROJECT. 3984 03:04:04,099 --> 03:04:07,503 AND LATER WE'LL HEAR MORE ABOUT 3985 03:04:07,569 --> 03:04:09,638 COMPONENT 2, THE COHORT 3986 03:04:09,705 --> 03:04:11,907 DEVELOPMENT PROJECT THROUGH THE 3987 03:04:11,974 --> 03:04:14,343 LENS OF THE INCLUDE DATA 3988 03:04:14,410 --> 03:04:14,810 COORDINATING CENTER. 3989 03:04:14,877 --> 03:04:16,578 TOMORROW WE'LL HERE MORE ABOUT 3990 03:04:16,645 --> 03:04:19,448 THE CLINICAL TRIALS AS WELL. 3991 03:04:19,515 --> 03:04:21,884 I THINK THE IDEAS THAT ALL OF 3992 03:04:21,950 --> 03:04:25,687 THESE COMPONENTS ARE WORKING 3993 03:04:25,754 --> 03:04:26,855 TOWARDS SOME COMMON GOALS AND WE 3994 03:04:26,922 --> 03:04:28,724 WANT TO GENERATE RESEARCH TO 3995 03:04:28,791 --> 03:04:30,726 IMPROVE TREATMENTS AND 3996 03:04:30,793 --> 03:04:31,960 INTERVENTIONS FOR PEOPLE WITH 3997 03:04:32,027 --> 03:04:32,294 DOWN SYNDROME. 3998 03:04:32,361 --> 03:04:33,529 WE WANT TO IMPROVE THE QUALITY 3999 03:04:33,595 --> 03:04:34,129 OF LIFE FOR PEOPLE WITH DOWN 4000 03:04:34,196 --> 03:04:37,065 SYNDROME. 4001 03:04:37,132 --> 03:04:40,769 AND ULTIMATELY WE HOPE TO 4002 03:04:40,836 --> 03:04:41,937 IMPROVE INFORMATION OF VARIOUS 4003 03:04:42,004 --> 03:04:44,673 DISEASE STATES TO BENEFIT THE 4004 03:04:44,740 --> 03:04:45,240 GENERAL POPULATION AS WELL. 4005 03:04:45,307 --> 03:04:51,313 SO HOW DO WE BEST ACHIEVE 4006 03:04:51,380 --> 03:04:51,547 SUCCESS? 4007 03:04:51,613 --> 03:04:58,587 WE'LL TRY TO CONVINCE YOU CROSS 4008 03:04:58,654 --> 03:04:59,288 COLLABORATION WILL HELP 4009 03:04:59,354 --> 03:05:01,223 TRANSLATE FROM BENCH TO BEDSIDE 4010 03:05:01,290 --> 03:05:03,392 AND WANT TO CLOSE THE GAP TWO 4011 03:05:03,459 --> 03:05:05,227 SOMETIMES DIFFERENT WORLDS, 4012 03:05:05,294 --> 03:05:06,595 LABORATORY, BASIC SCIENCE 4013 03:05:06,662 --> 03:05:10,499 RESEARCH AND CLINICAL CLINICAL 4014 03:05:10,566 --> 03:05:15,904 MED SPIN WE HOPE TO CONNECT 4015 03:05:15,971 --> 03:05:17,473 RESEARCHERS ACROSS FIELDS THAT 4016 03:05:17,539 --> 03:05:18,574 ARE RELEVANT AND DO THIS THROUGH 4017 03:05:18,640 --> 03:05:19,908 SOME BREAKOUT SESSIONS. 4018 03:05:19,975 --> 03:05:21,510 THIS MEETING IS AN OPPORTUNITY 4019 03:05:21,577 --> 03:05:22,611 TO COME TOGETHER. 4020 03:05:22,678 --> 03:05:24,012 WARE ALL IN THE SAME PHYSICAL 4021 03:05:24,079 --> 03:05:27,115 ENVIRONMENT AND WE WANT TO GET 4022 03:05:27,182 --> 03:05:28,116 YOU GUYS TALKING. 4023 03:05:28,183 --> 03:05:31,253 WE WANT TO SHARE CHALLENGES AND 4024 03:05:31,320 --> 03:05:32,955 LESSONS LEARNED AND IDEAS TO 4025 03:05:33,021 --> 03:05:33,689 HELP FIGURE OUT THE FUTURE 4026 03:05:33,755 --> 03:05:35,090 DIRECTION FOR THE INCLUDE 4027 03:05:35,157 --> 03:05:39,094 PROJECT. 4028 03:05:39,161 --> 03:05:45,100 WE'LL HAVE BREAKOUTS AND WE'LL 4029 03:05:45,167 --> 03:05:51,940 HAVE NEURAL DEVELOPMENTAL 1 AND 4030 03:05:52,007 --> 03:05:54,776 THE SECOND GROUP IS COGNITION, 4031 03:05:54,843 --> 03:05:57,913 REGRESSION AND AUTISM AND ADHD 4032 03:05:57,980 --> 03:05:59,815 AND STRUCTURAL AND BIRTH DEFECTS 4033 03:05:59,882 --> 03:06:02,017 AND FOR THE IMMUNE SYSTEM 4034 03:06:02,084 --> 03:06:03,252 DYSREGULATION AND ONE FOR 4035 03:06:03,318 --> 03:06:03,919 ALZHEIMER'S DISEASE AND ONE FOR 4036 03:06:03,986 --> 03:06:06,388 SLEEP. 4037 03:06:06,455 --> 03:06:08,790 ACROSS THESE DIFFERENT AREAS, WE 4038 03:06:08,857 --> 03:06:12,361 WANT TO TALK ABOUT GAPS IN 4039 03:06:12,427 --> 03:06:13,328 SUPPORT STRATEGIES AND 4040 03:06:13,395 --> 03:06:15,764 DIRECTIONS TO ADVANCE THE FIELD, 4041 03:06:15,831 --> 03:06:18,166 WAYS TO HARNESS ARTIFICIAL 4042 03:06:18,233 --> 03:06:19,301 INTELLIGENCE AND EMERGING 4043 03:06:19,368 --> 03:06:21,937 TECHNOLOGIES AND PROMISING AREAS 4044 03:06:22,004 --> 03:06:23,138 OF INTEREST. 4045 03:06:23,205 --> 03:06:26,508 IN TERMS OF THE SESSION FORMAT 4046 03:06:26,575 --> 03:06:31,446 THERE WILL BE INVESTIGATOR LEADS 4047 03:06:31,513 --> 03:06:33,115 MODERATING THE DISCUSSION USING 4048 03:06:33,181 --> 03:06:36,818 PROMPTS AND QUESTION TO HELP 4049 03:06:36,885 --> 03:06:37,819 GUIDE THE DISCUSSION AND HAVE A 4050 03:06:37,886 --> 03:06:39,187 REPRESENTATIVE FROM THE NIH TEAM 4051 03:06:39,254 --> 03:06:41,323 IN EACH SESSION TO HELP KEEP 4052 03:06:41,390 --> 03:06:45,494 THINGS ON TRACK AND YOU GUYS AS 4053 03:06:45,561 --> 03:06:47,329 INVESTIGATORS SHOULD SELF-SELECT 4054 03:06:47,396 --> 03:06:50,599 TO THE TOPIC AREA THAT BEST FITS 4055 03:06:50,666 --> 03:06:51,199 YOUR RESEARCH INTERESTS. 4056 03:06:51,266 --> 03:06:52,334 WE'LL HAVE DISCUSSIONS 4057 03:06:52,401 --> 03:06:53,335 THROUGHOUT THE LUNCH PERIOD AND 4058 03:06:53,402 --> 03:06:55,470 THEN THOSE WILL ULTIMATELY BE 4059 03:06:55,537 --> 03:06:57,839 SUMMARIZED BY THE GROUP LEAD AND 4060 03:06:57,906 --> 03:07:01,410 WE'LL DO FIVE-MINUTE REPORT OUTS 4061 03:07:01,476 --> 03:07:03,545 TOWARD THE END OF THE MEETING. 4062 03:07:03,612 --> 03:07:07,683 OUR GOALS ARE TO UNDERSTAND GAPS 4063 03:07:07,749 --> 03:07:10,085 AND CHALLENGES THAT GET A BETTER 4064 03:07:10,152 --> 03:07:11,353 GRASP OF THE RESEARCH LANDSCAPE 4065 03:07:11,420 --> 03:07:13,622 AND WORK ON NETWORKING, 4066 03:07:13,689 --> 03:07:14,389 PROFESSIONAL GROWTH AND 4067 03:07:14,456 --> 03:07:15,924 HOPEFULLY MAKE NEW CONNECTS 4068 03:07:15,991 --> 03:07:17,159 BETWEEN INVESTIGATORS TO HELP 4069 03:07:17,225 --> 03:07:18,660 GUIDE NEW DIRECTION FOR 4070 03:07:18,727 --> 03:07:19,595 RESEARCH. 4071 03:07:19,661 --> 03:07:21,930 WE WANT TO HEAR OPINIONS ACROSS 4072 03:07:21,997 --> 03:07:25,000 THE BOARD. 4073 03:07:25,067 --> 03:07:27,002 THIS IS A LISTING OF THE 4074 03:07:27,069 --> 03:07:27,569 DIFFERENT ROOMS. 4075 03:07:27,636 --> 03:07:29,137 SO PLEASE TAKE A LOOK AT THIS 4076 03:07:29,204 --> 03:07:32,574 AND FIGURE OUT WHAT TOPIC BEST 4077 03:07:32,641 --> 03:07:34,409 REPRESENTS YOUR RESEARCH AND 4078 03:07:34,476 --> 03:07:37,112 WHERE YOU'LL BE GOING. 4079 03:07:37,179 --> 03:07:38,947 THERE WILL BE BOX LUNCHES THAT 4080 03:07:39,014 --> 03:07:40,248 HAVE BEEN ORDERED YOU'LL PICK UP 4081 03:07:40,315 --> 03:07:47,956 AND TAKE TOE -- TO THE ASSIGNED 4082 03:07:48,023 --> 03:07:48,357 ROOM. 4083 03:07:48,423 --> 03:07:49,825 ALL THESE ROOMS YOU CAN EAT AND 4084 03:07:49,891 --> 03:07:52,761 DRINK UNLIKE THE CURRENT ROOM. 4085 03:07:52,828 --> 03:07:54,062 WITHOUT FURTHER ADO I THINK 4086 03:07:54,129 --> 03:07:54,496 WE'RE READY TO GO. 4087 03:07:54,563 --> 03:07:58,834 THANK YOU, EVERYBODY. 4088 03:07:58,900 --> 03:08:03,672 GOOD AFTERNOON 4089 03:08:03,739 --> 03:08:09,277 AND I'M WITH THE NATIONAL HEART, 4090 03:08:09,344 --> 03:08:11,780 LUNG, BLOOD, INSTITUTE. 4091 03:08:11,847 --> 03:08:14,383 WE HAVE A PRODUCT SCIENTIST FOR 4092 03:08:14,449 --> 03:08:15,617 THE DATA DISEASE COORDINATE 4093 03:08:15,684 --> 03:08:16,118 CANNING CENTER. 4094 03:08:16,184 --> 03:08:19,888 IT'S BEEN A PRIVILEGE TO AGREE 4095 03:08:19,955 --> 03:08:22,290 TOGETHER WITH A GREAT TEAM AND 4096 03:08:22,357 --> 03:08:24,760 IT'S MY GREAT PLEASURE AND HONOR 4097 03:08:24,826 --> 03:08:27,663 TO INTRODUCE THE OUTSTANDING 4098 03:08:27,729 --> 03:08:28,997 INCLUDE DATA LEARNING CENTER 4099 03:08:29,064 --> 03:08:31,667 TEAM. 4100 03:08:31,733 --> 03:08:37,806 TODAY WE HAVE SIX SPEAKERS WE'LL 4101 03:08:37,873 --> 03:08:39,341 INTRODUCE ALL OF THEM TO SAVE 4102 03:08:39,408 --> 03:08:40,942 TIME FOR TRANSITION. 4103 03:08:41,009 --> 03:08:47,916 THE FIRST SPEAKER IS ESPINOZA 4104 03:08:47,983 --> 03:08:52,187 WHO IS FROM THE CERNIC INSTITUTE 4105 03:08:52,254 --> 03:08:56,525 AND DR. HANDEL FROM UNIVERSITY 4106 03:08:56,591 --> 03:08:58,326 OF NORTH CAROLINA AND TODAY'S 4107 03:08:58,393 --> 03:09:03,265 HER FIRST OFFICIAL DAY AT UNC 4108 03:09:03,331 --> 03:09:11,840 AND DR. ALFROTI FROM MONTREAL 4109 03:09:11,907 --> 03:09:21,883 AND DR. SAHA ON BEHALF OF OTHERS 4110 03:09:21,950 --> 03:09:26,121 AND THE LAST BUT NOT LEAST 4111 03:09:26,188 --> 03:09:28,590 DR. RESNIK FROM CHILDREN'S 4112 03:09:28,657 --> 03:09:30,425 HOSPITAL OF PHILADELPHIA. 4113 03:09:30,492 --> 03:09:37,265 WELCOME ALL OF THEM AND 4114 03:09:37,332 --> 03:09:38,333 MR. DAVID EAGAN WILL INTRODUCE 4115 03:09:38,400 --> 03:09:47,075 THE TEAM. 4116 03:09:47,142 --> 03:09:49,745 WE MAY NOT HAVE TIME FOR Q&A 4117 03:09:49,811 --> 03:09:54,716 HOWEVER, WE HAVE A NIGHT 4118 03:09:54,783 --> 03:10:05,293 RECEPTION AT THE HYATT HOTEL. 4119 03:10:07,129 --> 03:10:09,831 HOW'S EVERYBODY DOING? 4120 03:10:09,898 --> 03:10:13,535 I'M DAVID EAGAN A MAN WITH DOWN 4121 03:10:13,602 --> 03:10:14,369 SYNDROME TO ADVOCATE FOR 4122 03:10:14,436 --> 03:10:17,672 RESEARCH AND IT'S AN HONOR TO 4123 03:10:17,739 --> 03:10:20,809 INTRODUCE DR. ESPINOZA AND HIS 4124 03:10:20,876 --> 03:10:23,678 TEAM IN THE DATA COORDINATING 4125 03:10:23,745 --> 03:10:24,346 CENTER. 4126 03:10:24,412 --> 03:10:28,049 THE DCC IS A CRITICAL CENTER AND 4127 03:10:28,116 --> 03:10:29,751 IMPORTANT PIECE TO ENSURE ALL 4128 03:10:29,818 --> 03:10:32,053 THE RESEARCHERS COULD HAVE 4129 03:10:32,120 --> 03:10:32,654 MEANINGFUL PROJECTS WITH REAL 4130 03:10:32,721 --> 03:10:42,697 DATA. 4131 03:10:42,764 --> 03:10:44,566 AS MANY KNOW ME I'M AN ADVOCATE 4132 03:10:44,633 --> 03:10:47,502 AND SUPPORTER OF RESEARCH. 4133 03:10:47,569 --> 03:10:51,406 ESPECIALLY WHEN IT'S RELATED TO 4134 03:10:51,473 --> 03:10:52,507 DOWN SYNDROME ISSUES. 4135 03:10:52,574 --> 03:10:53,508 HAVE I BEEN INVOLVED IN RESEARCH 4136 03:10:53,575 --> 03:10:55,677 STUDIES FOR A LONG TIME AND 4137 03:10:55,744 --> 03:10:57,646 CONTINUE TO BE ENGAGED AS A 4138 03:10:57,712 --> 03:10:59,447 PARTICIPANT AND HOPEFULLY A 4139 03:10:59,514 --> 03:11:03,485 BENEFICIARY OF THE FINDINGS AND 4140 03:11:03,552 --> 03:11:04,085 RECOMMENDATIONS IN THE NEAR 4141 03:11:04,152 --> 03:11:11,293 FUTURE. 4142 03:11:11,359 --> 03:11:14,963 I WOULD LIKE TO ENCOURAGE TO YOU 4143 03:11:15,030 --> 03:11:16,131 PARTICIPATE AND SHARE YOUR DATA 4144 03:11:16,198 --> 03:11:24,506 WITH A DATA COORDINATING CENTER. 4145 03:11:24,573 --> 03:11:25,774 RESEARCH IN THE PAST 40 YEARS 4146 03:11:25,841 --> 03:11:27,676 HAVE MADE IT POSSIBLE FOR US TO 4147 03:11:27,742 --> 03:11:29,311 LIVE LONGER. 4148 03:11:29,377 --> 03:11:34,883 MANY QUESTIONS STILL HAVE NO 4149 03:11:34,950 --> 03:11:36,051 ANSWERS AND MORE RESEARCH AND 4150 03:11:36,117 --> 03:11:37,752 BREAKTHROUGHS ARE NEEDED TO 4151 03:11:37,819 --> 03:11:38,420 IMPROVE THE QUALITY OF OUR 4152 03:11:38,486 --> 03:11:41,256 LIVES. 4153 03:11:41,323 --> 03:11:44,159 IN THE PAST TWO YEARS, AFTER 4154 03:11:44,226 --> 03:11:46,761 COVID I'VE BEEN VERY SICK AND 4155 03:11:46,828 --> 03:11:49,798 LOST 85 POUNDS. 4156 03:11:49,865 --> 03:11:57,739 IT WAS A VERY SHORT TIME. 4157 03:11:57,806 --> 03:11:59,908 I WAS IN THE HOSPITAL THREE 4158 03:11:59,975 --> 03:12:00,175 TIMES. 4159 03:12:00,242 --> 03:12:03,144 ENDING UP IN THE INTENSIVE 4160 03:12:03,211 --> 03:12:03,778 CARDIAC UNIT WITH A COLLAPSED 4161 03:12:03,845 --> 03:12:08,016 LUNG. 4162 03:12:08,083 --> 03:12:11,686 I FEEL BETTER NOW AND I'M ON THE 4163 03:12:11,753 --> 03:12:13,288 ROAD TO RECOVERY. 4164 03:12:13,355 --> 03:12:17,292 I HAVE TO TELL YOU THAT MANY OF 4165 03:12:17,359 --> 03:12:18,693 THE HEALTH PROFESSIONALS DID NOT 4166 03:12:18,760 --> 03:12:25,634 KNOW WHAT WAS HAPPENING TO ME. 4167 03:12:25,700 --> 03:12:31,506 AND WE NEED MORE DATA TO UNVEIL 4168 03:12:31,573 --> 03:12:32,274 SOME OF THE UNIQUE HEALTH ISSUES 4169 03:12:32,340 --> 03:12:39,447 WE FACE. 4170 03:12:39,514 --> 03:12:43,652 WHY SHOULD I CARE IN DOWN 4171 03:12:43,718 --> 03:12:44,185 SYNDROME INCLUDE PROGRAM? 4172 03:12:44,252 --> 03:12:45,553 I STRONGLY PLAY RESEARCH CAN 4173 03:12:45,620 --> 03:12:47,656 PLAY A CRITICAL ROLE IN OUR WELL 4174 03:12:47,722 --> 03:12:49,958 BEING. 4175 03:12:50,025 --> 03:12:54,529 GOOD RESEARCH IS THE BEST 4176 03:12:54,596 --> 03:12:54,829 INVESTMENT. 4177 03:12:54,896 --> 03:12:59,634 MAYBE A LONG PROCESS AS OUR 4178 03:12:59,701 --> 03:13:01,069 PARENTS WHO ARE RESEARCHERS 4179 03:13:01,136 --> 03:13:04,039 EXPLAIN TO ME DISCOVERIES DO NOT 4180 03:13:04,105 --> 03:13:06,174 TRANSLATE IMMEDIATELY INTO 4181 03:13:06,241 --> 03:13:06,441 REMEDIES. 4182 03:13:06,508 --> 03:13:09,577 IT TAKES TIME AND A TEAM TO TAKE 4183 03:13:09,644 --> 03:13:11,146 SCIENCE FROM THE LAB INTO THE 4184 03:13:11,212 --> 03:13:11,846 MARKET AND IN THE HOMES OF THOSE 4185 03:13:11,913 --> 03:13:17,552 WHO NEED IT. 4186 03:13:17,619 --> 03:13:19,654 WHEN I TURNED 40 SIX YEARS AGO, 4187 03:13:19,721 --> 03:13:23,792 I WONDERED WHAT THE FUTURE WOULD 4188 03:13:23,858 --> 03:13:24,859 LOOK LIKE. 4189 03:13:24,926 --> 03:13:29,664 WHILE WE MADE SOME PROGRESS AND 4190 03:13:29,731 --> 03:13:31,967 ACCEPTED PEOPLE WITH 4191 03:13:32,033 --> 03:13:37,739 INTELLECTUAL DISABILITIES, 4192 03:13:37,806 --> 03:13:39,007 EFFORTS HAVE BEEN IMPROVED AND 4193 03:13:39,074 --> 03:13:39,674 THERE'S STILL BARRIERS TO 4194 03:13:39,741 --> 03:13:44,279 HEALTHY LIVING. 4195 03:13:44,346 --> 03:13:47,649 WE HAVE NOT YET EXPLORED HOW TO 4196 03:13:47,716 --> 03:13:49,284 GROW NEURONS IN THE BRAIN, 4197 03:13:49,351 --> 03:13:52,120 IMPROVE MEMORY, COGNITION, 4198 03:13:52,187 --> 03:13:52,754 LEARNING AND INCREASE OUR WELL 4199 03:13:52,821 --> 03:13:54,956 BEING. 4200 03:13:55,023 --> 03:13:57,659 WE ALL NEED TO BE ACTIVE 4201 03:13:57,726 --> 03:14:04,466 PARTICIPANTS IN THAT PROCESS. 4202 03:14:04,532 --> 03:14:05,600 RESEARCH HAS ALWAYS BEEN 4203 03:14:05,667 --> 03:14:08,169 IMPORTANT TO ME AND MY FAMILY. 4204 03:14:08,236 --> 03:14:09,337 IVE I'M INVOLVED IN THE NIH 4205 03:14:09,404 --> 03:14:12,007 EFFORTS AND PARTICIPATED IN THE 4206 03:14:12,073 --> 03:14:17,846 PROJECT. 4207 03:14:17,912 --> 03:14:19,647 RESEARCH IN THE HUMAN CONDITION 4208 03:14:19,714 --> 03:14:22,684 IS AN AMAZING SUBJECT. 4209 03:14:22,751 --> 03:14:24,185 IT'S A FIELD THAT IS OF HIGH 4210 03:14:24,252 --> 03:14:27,655 INTEREST TO ME AND ALL OF US AS 4211 03:14:27,722 --> 03:14:31,659 WE THRIVE FOR A BETTER QUALITY 4212 03:14:31,726 --> 03:14:32,360 OF LIFE. 4213 03:14:32,427 --> 03:14:35,663 IT MATTERS TO ALL OF US WITH OR 4214 03:14:35,730 --> 03:14:37,465 WITHOUT A DISABILITY. 4215 03:14:37,532 --> 03:14:42,737 IN MY BOOK, MORE LIKE I HAVE A 4216 03:14:42,804 --> 03:14:43,638 FULL CHAPTER HIGHLIGHTING HOW 4217 03:14:43,705 --> 03:14:47,709 RESEARCH INPART HAS SHAPED MY 4218 03:14:47,776 --> 03:14:48,143 LIFE. 4219 03:14:48,209 --> 03:14:51,446 AND HOPEFULLY IT WILL IMPROVE 4220 03:14:51,513 --> 03:14:55,650 ALL OF OUR LIVES AND THAT OF OUR 4221 03:14:55,717 --> 03:14:56,251 LOVED ONES. 4222 03:14:56,317 --> 03:15:00,088 IN FACT OUR QUALITY OF LIFE THAT 4223 03:15:00,155 --> 03:15:05,326 MANY OTHERS WITH AND WITHOUT 4224 03:15:05,393 --> 03:15:09,764 DOWN SYNDROME COULD BE IMPROVED 4225 03:15:09,831 --> 03:15:11,800 WITH FURTHER RESEARCH FROM THE 4226 03:15:11,866 --> 03:15:12,500 WOMB TO THE GRAVE. 4227 03:15:12,567 --> 03:15:18,039 OTHER RESEARCH IS NEEDED AND THE 4228 03:15:18,106 --> 03:15:19,607 CHROMOSOME MAY UNLOCK NOT ONLY 4229 03:15:19,674 --> 03:15:20,275 THOSE WITH DOWN SYNDROME BUT ALL 4230 03:15:20,341 --> 03:15:23,845 OF US. 4231 03:15:23,912 --> 03:15:26,114 I'M NOT ASKING SCIENTIST TO 4232 03:15:26,181 --> 03:15:26,714 CHANGE ME. 4233 03:15:26,781 --> 03:15:29,451 I'M COMFORTABLE WITH WHO I AM. 4234 03:15:29,517 --> 03:15:31,252 ANYTHING THAT CAN GIVE US AN 4235 03:15:31,319 --> 03:15:32,587 EDGE TO LIVE FULFILLING LIVES IS 4236 03:15:32,654 --> 03:15:34,522 WORTH PURSUING. 4237 03:15:34,589 --> 03:15:38,259 I WANT YOU TO JOIN ME AND 4238 03:15:38,326 --> 03:15:42,197 DR. ESPINOZA IN THESE EFFORTS. 4239 03:15:42,263 --> 03:15:43,598 WE'RE HOPING TO GETTING YOU 4240 03:15:43,665 --> 03:15:49,304 FIRED UP AND READY TO 4241 03:15:49,370 --> 03:15:50,004 PARTICIPATE. 4242 03:15:50,071 --> 03:15:51,239 REMEMBER WE THE PEOPLE WITH DOWN 4243 03:15:51,306 --> 03:15:53,007 SYNDROME DO MATTER AND WE NEED 4244 03:15:53,074 --> 03:15:53,441 YOUR PARTICIPATION. 4245 03:15:53,508 --> 03:16:01,282 AND THIS IS A QUAL TO ACTION. 4246 03:16:01,349 --> 03:16:06,387 ARE YOU READY TO ENGAGE AND 4247 03:16:06,454 --> 03:16:06,588 SHARE? 4248 03:16:06,654 --> 03:16:07,689 ARE YOU? 4249 03:16:07,755 --> 03:16:12,327 JUST CHECKING. 4250 03:16:12,393 --> 03:16:14,262 AND NOW IT'S MY PLEASURE TO 4251 03:16:14,329 --> 03:16:17,465 INTRODUCE DR. ESPINOZA, THE 4252 03:16:17,532 --> 03:16:18,766 LEADING SCIENTISTS IN OUR 4253 03:16:18,833 --> 03:16:19,868 COMMUNITY TO GIVE US MORE 4254 03:16:19,934 --> 03:16:21,469 INSIGHT INTO THE RESEARCH 4255 03:16:21,536 --> 03:16:23,738 EFFORTS AND KEY CONTRIBUTIONS 4256 03:16:23,805 --> 03:16:26,274 FROM THE NIH DATA COORDINATING 4257 03:16:26,341 --> 03:16:26,541 CENTER. 4258 03:16:26,608 --> 03:16:31,312 IN THE NAME OF ALL INDIVIDUALS 4259 03:16:31,379 --> 03:16:33,414 WHO SHARE WITH ME IN EXTRA 4260 03:16:33,481 --> 03:16:35,683 CHROMOSOMES AND ALL OF THEIR 4261 03:16:35,750 --> 03:16:36,217 FAMILIES. 4262 03:16:36,284 --> 03:16:38,820 I'D LIKE TO THANK DR. ESPINOZA 4263 03:16:38,887 --> 03:16:39,487 AND HIS TEAM. 4264 03:16:39,554 --> 03:16:42,790 PLEASE JOIN ME IN WELCOMING THE 4265 03:16:42,857 --> 03:16:44,058 LEADER OF THE DATA COORDINATING 4266 03:16:44,125 --> 03:16:45,927 CENTER AND MY FRIEND, 4267 03:16:45,994 --> 03:16:56,237 DR. ESPINOZA. 4268 03:17:10,652 --> 03:17:12,387 >> OUR FRIENDS IN THE BACK OF 4269 03:17:12,453 --> 03:17:19,127 THE ROOM HELP US GET THE SLIDES 4270 03:17:19,194 --> 03:17:27,669 GOING, I WANT TO I'M VERY HAPPY 4271 03:17:27,735 --> 03:17:28,403 YOU'RE BACK. 4272 03:17:28,469 --> 03:17:31,606 WE WERE VERY WORRIED ABOUT YOU 4273 03:17:31,673 --> 03:17:34,375 WHEN YOU WERE FIGHTING WITH 4274 03:17:34,442 --> 03:17:35,376 RECOVERY. 4275 03:17:35,443 --> 03:17:37,779 HE DIDN'T SAY HE GOT COVID IN 4276 03:17:37,845 --> 03:17:40,915 THE LINE OF DUTY HE WAS IN 4277 03:17:40,982 --> 03:17:43,651 CONGRESS ADVOCATING, INSPIRING 4278 03:17:43,718 --> 03:17:45,253 AND ADVANCING AND THAT'S HOW WE 4279 03:17:45,320 --> 03:17:48,623 GOT COVID AND HE WAS IN A BAD 4280 03:17:48,690 --> 03:17:48,823 PLACE. 4281 03:17:48,890 --> 03:17:50,892 BUT MOM NEVER GAVE UP. 4282 03:17:50,959 --> 03:17:54,295 SHE TALKED TO A LOT OF US. 4283 03:17:54,362 --> 03:17:58,032 SHE EXPLORED OPTIONS AND 4284 03:17:58,099 --> 03:17:58,633 ACCEPTED THAT STATE AND NOW 4285 03:17:58,700 --> 03:18:08,943 DAVID IS BACK. 4286 03:18:10,245 --> 03:18:16,918 MY NAME IS JUAQUIN HE ESPINOZA 4287 03:18:16,985 --> 03:18:19,187 I'M HAPPY TO INCLUDE THE WORK OF 4288 03:18:19,254 --> 03:18:21,055 THE INCLUDE COORDINATING CENTER. 4289 03:18:21,122 --> 03:18:23,925 OUR MISSION IS TO ACCELERATE 4290 03:18:23,992 --> 03:18:26,561 DISCOVERY WOULD IMPROVE AND 4291 03:18:26,628 --> 03:18:30,131 ENRICH THE PEOPLE OF LIVES WITH 4292 03:18:30,198 --> 03:18:30,632 DOWN SYNDROME THROUGH 4293 03:18:30,698 --> 03:18:32,267 COLLABORATION AND CONNECT TO 4294 03:18:32,333 --> 03:18:34,535 COMMUNITIES AND THE EXPANSION OF 4295 03:18:34,602 --> 03:18:35,536 A GLOBAL DOWN SYNDROME ECO 4296 03:18:35,603 --> 03:18:35,970 SYSTEM. 4297 03:18:36,037 --> 03:18:40,108 WE WILL DO THIS BY FOLLOWING THE 4298 03:18:40,174 --> 03:18:40,375 GUIDANCE. 4299 03:18:40,441 --> 03:18:43,344 WE HEARD THE CALL OF YEARS AGO 4300 03:18:43,411 --> 03:18:44,912 AND NIH CALLED FOR A DATA 4301 03:18:44,979 --> 03:18:46,214 COORDINATING CENTER THAT COULD 4302 03:18:46,281 --> 03:18:49,050 ACCELERATE DISCOVERY AND THE 4303 03:18:49,117 --> 03:18:51,152 PATHWAYS THAT ARE LEADING TO THE 4304 03:18:51,219 --> 03:18:53,921 CO-OCCURRING CONDITIONS BY 4305 03:18:53,988 --> 03:18:56,057 FACILITATING ACTION AND LOOKING 4306 03:18:56,124 --> 03:18:59,327 AT DATA FROM COHORTS OF 4307 03:18:59,394 --> 03:19:00,995 INDIVIDUALS WITH DOWN SYNDROME 4308 03:19:01,062 --> 03:19:02,997 AND WE'RE ORGANIZE THE WAY NIH 4309 03:19:03,064 --> 03:19:05,533 INSTRUCTED US TO IN THE 4310 03:19:05,600 --> 03:19:06,801 ADMINISTRATIVE AND OUTREACH 4311 03:19:06,868 --> 03:19:09,404 CORE, PROVIDING PROGRAM 4312 03:19:09,470 --> 03:19:12,440 MANAGEMENT, OUTREACH AND 4313 03:19:12,507 --> 03:19:17,478 EDUCATION AND THE HARMONIZATION 4314 03:19:17,545 --> 03:19:20,782 OF DATA AND CREATING THE ONLINE 4315 03:19:20,848 --> 03:19:21,783 WEB PORTAL. 4316 03:19:21,849 --> 03:19:23,918 MY COLLEAGUES LEAD THE 4317 03:19:23,985 --> 03:19:28,022 ADMINISTRATIVE AND OUTREACH CORE 4318 03:19:28,089 --> 03:19:31,659 AND THEY OVERSEE THE DATA 4319 03:19:31,726 --> 03:19:34,829 MANAGEMENT CORE AND ADAM, 4320 03:19:34,896 --> 03:19:37,799 VINCENT AND JACK REPRESENTED BY 4321 03:19:37,865 --> 03:19:40,968 THE CORE AND SIX P.I.s AND 4322 03:19:41,035 --> 03:19:42,670 DIVERSITY OF OPINIONS AND 4323 03:19:42,737 --> 03:19:42,970 APPROACHES. 4324 03:19:43,037 --> 03:19:45,206 THIS IS A CLOSE COLLABORATION 4325 03:19:45,273 --> 03:19:47,241 WITH NIH AND THE IT PROJECT 4326 03:19:47,308 --> 03:19:50,278 SCIENTIST IS INVOLVED IN EVERY 4327 03:19:50,345 --> 03:19:51,612 DECISION SO ARE SEVERAL OTHER 4328 03:19:51,679 --> 03:19:55,450 PROGRAM OFFICERS LISTED HERE. 4329 03:19:55,516 --> 03:20:00,588 AND THE POINT OF OUR STUDY IS 4330 03:20:00,655 --> 03:20:02,990 WHERE WE HAVE A SIZABLE 4331 03:20:03,057 --> 03:20:05,460 POPULATION WHERE WE CAN LOOK AT 4332 03:20:05,526 --> 03:20:07,128 THOUSAND OF MEDICAL RECORDS TO 4333 03:20:07,195 --> 03:20:09,263 REVEAL THEY HAVE A DIFFERENT 4334 03:20:09,330 --> 03:20:11,532 CLINICAL RISK PROFILE. 4335 03:20:11,599 --> 03:20:14,302 IT'S VERY RARE TO HEAR WHEN A 4336 03:20:14,369 --> 03:20:16,537 DIFFICULT IS HAVING CONSEQUENCE, 4337 03:20:16,604 --> 03:20:17,405 FOR EXAMPLE. 4338 03:20:17,472 --> 03:20:18,806 FOR EXAMPLE, THEY'RE HIGHLY 4339 03:20:18,873 --> 03:20:22,510 PREDISPOSED TO THE NUMBER OF 4340 03:20:22,577 --> 03:20:23,644 CONDITIONS SHOWN HERE AND 4341 03:20:23,711 --> 03:20:27,448 CANCER, ATHEROSCLEROSIS, 4342 03:20:27,515 --> 03:20:29,484 HYPERTENSION AND ALLERGIES AND 4343 03:20:29,550 --> 03:20:30,218 AUTO IMMUNITY AND ALZHEIMER'S 4344 03:20:30,284 --> 03:20:36,023 AND LIEUKEMIAS AND COVID-19. 4345 03:20:36,090 --> 03:20:37,859 TO HELP THEM LIVE LONGER WE JUST 4346 03:20:37,925 --> 03:20:40,895 NOT ONLY STUDY THESE BUT THE 4347 03:20:40,962 --> 03:20:42,764 MECHANISMS BY WHICH THE EXTRA 4348 03:20:42,830 --> 03:20:43,831 CHROMOSOME CAUSE THE 4349 03:20:43,898 --> 03:20:44,966 CO-OCCURRING CONDITIONS. 4350 03:20:45,032 --> 03:20:48,236 HOW ARE WE GOING IT MAKE 4351 03:20:48,302 --> 03:20:48,536 DISCOVERIES? 4352 03:20:48,603 --> 03:20:51,372 WE'RE GOING LET PEOPLE WITH DOWN 4353 03:20:51,439 --> 03:20:55,176 SYNDROME HELP US AND LOOK AT A 4354 03:20:55,243 --> 03:20:59,046 PEOPLE WITH GREAT DETAIL NOT TOO 4355 03:20:59,113 --> 03:21:02,049 INDIVIDUAL AND YES, SOME OF THEM 4356 03:21:02,116 --> 03:21:05,586 IN THE PICTURE MAY HAVE MULTIPLE 4357 03:21:05,653 --> 03:21:07,755 CO-OCCURRING CONDITIONS, SOME 4358 03:21:07,822 --> 03:21:09,357 MAY NOT AND SOME MAY PLAY 4359 03:21:09,424 --> 03:21:11,492 SEVERAL MUSICAL INSTRUMENTS IN 4360 03:21:11,559 --> 03:21:15,696 FRONT OF LARGE AUDIENCES AND 4361 03:21:15,763 --> 03:21:17,265 SOME MAY NOT AND THESE DIVERSITY 4362 03:21:17,331 --> 03:21:21,536 PRODUCE DISCOVERIES. 4363 03:21:21,602 --> 03:21:22,837 WE BELIEVE IN THE PERSONALIZED 4364 03:21:22,904 --> 03:21:23,971 MEDICINE APPROACH. 4365 03:21:24,038 --> 03:21:26,507 YOU ALL HAVE GREAT IDEAS WHAT IS 4366 03:21:26,574 --> 03:21:30,611 CAUSING THIS AND SOME THINK IT'S 4367 03:21:30,678 --> 03:21:32,313 GENETIC VARIANCE AFFECT THE 4368 03:21:32,380 --> 03:21:35,616 CHROMOSOME OR MODIFIER GENES AND 4369 03:21:35,683 --> 03:21:37,919 SOME MAY BELIEVE IN EPIGENETIC 4370 03:21:37,985 --> 03:21:43,024 MECHANISMS ACQUIRED DURING 4371 03:21:43,090 --> 03:21:44,859 DEVELOPMENT AND IT'S POSSIBLE 4372 03:21:44,926 --> 03:21:46,727 THE PHENOTYPES OF DOWN SYNDROME 4373 03:21:46,794 --> 03:21:52,533 ARE MATCHED BY VARIATIONS IN THE 4374 03:21:52,600 --> 03:21:56,771 ENDO TYPE AND WE'LL LOOK AT 4375 03:21:56,838 --> 03:22:00,074 RACE, ETHNICITY, LIFESTYLE AND 4376 03:22:00,141 --> 03:22:02,076 SOCIAL FACTORS AND WE NEED AN 4377 03:22:02,143 --> 03:22:04,879 EFFORT TO AID US IN TESTING 4378 03:22:04,946 --> 03:22:07,014 THEY'LL HYPOTHESES WITHIN OUR 4379 03:22:07,081 --> 03:22:08,049 LIFE TIMES. 4380 03:22:08,115 --> 03:22:11,686 I'M SO THRILLED TO SHARE WITH 4381 03:22:11,752 --> 03:22:14,722 YOU THERE ARE MORE THAN 50 4382 03:22:14,789 --> 03:22:16,691 INCLUDE-FUNDED COHORT STUDIES. 4383 03:22:16,757 --> 03:22:18,125 NEVER EVER IN THE HISTORY OF 4384 03:22:18,192 --> 03:22:20,328 HUMAN KIND WERE THERE SO MANY 4385 03:22:20,394 --> 03:22:24,665 SCIENTISTS TRYING TO HELP PEOPLE 4386 03:22:24,732 --> 03:22:25,233 WITH DOWN SYNDROME ACROSS 4387 03:22:25,299 --> 03:22:25,700 DIFFERENT INSTITUTES. 4388 03:22:25,766 --> 03:22:28,636 THE DIVERSITY OF APPROACHES AND 4389 03:22:28,703 --> 03:22:31,205 PLATFORMS, THOUSAND OF 4390 03:22:31,272 --> 03:22:32,507 PARTICIPANTS RECRUITED IN 4391 03:22:32,573 --> 03:22:34,475 RESEARCH STUDIES ACROSS THE USA. 4392 03:22:34,542 --> 03:22:35,776 NOW, YOU'RE ALL DOING YOUR THING 4393 03:22:35,843 --> 03:22:42,016 CH IS -- WHICH IS GREAT AND WEE 4394 03:22:42,083 --> 03:22:43,284 BETTER TOGETHER THROUGH THE 4395 03:22:43,351 --> 03:22:43,584 INTEGRATION. 4396 03:22:43,651 --> 03:22:46,420 WE PUT THE DATA TOGETHER, WE 4397 03:22:46,487 --> 03:22:49,023 HAVE A MORE DIVERSE COHORT AND 4398 03:22:49,090 --> 03:22:52,994 LARGER SAMPLE SIZE AND STRONGER 4399 03:22:53,060 --> 03:22:55,663 STATISTICAL POWER AND WE'LL BE 4400 03:22:55,730 --> 03:22:58,799 ABLE TO FILL IN GAPS THAT MAY BE 4401 03:22:58,866 --> 03:22:59,100 THERE. 4402 03:22:59,166 --> 03:23:01,235 SO WE'RE VERY HAPPY WITHIN 18 4403 03:23:01,302 --> 03:23:04,171 MONTHS OF STARTING OPERATIONS 4404 03:23:04,238 --> 03:23:07,308 AND THE SYNDROME, 2022, MARCH 4405 03:23:07,375 --> 03:23:10,444 21, 2022 WE LAUNCH THE DATA HUB 4406 03:23:10,511 --> 03:23:12,513 AND SINCE THEN WE HAVE BEEN 4407 03:23:12,580 --> 03:23:13,981 ADDING MORE STUDIES AND MORE 4408 03:23:14,048 --> 03:23:15,716 FEATURES TRYING TO MAKE IT 4409 03:23:15,783 --> 03:23:16,717 BETTER AND BETTER FOUR. 4410 03:23:16,784 --> 03:23:21,122 I WANT IT TAKE A MOMENT TO 4411 03:23:21,188 --> 03:23:23,658 ACKNOWLEDGE THE REMAINING 4412 03:23:23,724 --> 03:23:24,692 STUDIES CONTRIBUTING AND THESE 4413 03:23:24,759 --> 03:23:27,995 ARE THE MEMBERS OF PARTICIPANTS 4414 03:23:28,062 --> 03:23:30,798 AND I WOULD LIKE VERY MUCH HAVE 4415 03:23:30,865 --> 03:23:35,636 THE DATA SLIDE WITH MORE OF YOU. 4416 03:23:35,703 --> 03:23:40,908 IT'S OVERWHELMING BUT HAVING IT 4417 03:23:40,975 --> 03:23:43,010 LARGER IN TWO YEARS FROM NOW AND 4418 03:23:43,077 --> 03:23:45,580 IF YOU GO TO THE DATA HUB 4419 03:23:45,646 --> 03:23:47,882 THERE'S MORE THAN 9,000 DATA 4420 03:23:47,949 --> 03:23:51,118 SETS AND 4,000 PLUS WHOLE GENOME 4421 03:23:51,185 --> 03:23:52,587 SEQUENCES AND 1700 4422 03:23:52,653 --> 03:23:56,857 TRANSCRIPTOMES AND YOU LOOK AT 4423 03:23:56,924 --> 03:24:00,761 THE COGNITIVE DATA AND FITNESS 4424 03:24:00,828 --> 03:24:02,229 AND EXERCISE DATA AND WE'RE 4425 03:24:02,296 --> 03:24:07,602 MAKING SURE NO STONE IS LEFT 4426 03:24:07,668 --> 03:24:08,469 UNTURNED. 4427 03:24:08,536 --> 03:24:10,638 STUDYING THIS AND WHAT WE'RE 4428 03:24:10,705 --> 03:24:13,007 WITNESSING IS THE BURGEONING 4429 03:24:13,074 --> 03:24:14,875 DATA CONSISTENT AND FOR A LONG 4430 03:24:14,942 --> 03:24:16,444 TIME IT WAS ONLY. 4431 03:24:16,510 --> 03:24:18,012 THE ONLY RESEARCH FOR REPORTED 4432 03:24:18,079 --> 03:24:20,681 DATA FROM THE FAMILIES AND 4433 03:24:20,748 --> 03:24:26,053 SELF-ADVOCATE AND RECRUITMENT 4434 03:24:26,120 --> 03:24:29,090 TOOL AND DEVELOPED THE TRISOM 4435 03:24:29,156 --> 03:24:31,125 EXPLORER FOR THE DATA SETS AND 4436 03:24:31,192 --> 03:24:33,060 THE WEBSITE YOU CAN GO FIND ALL 4437 03:24:33,127 --> 03:24:35,463 THE INVESTIGATORS OR 4438 03:24:35,529 --> 03:24:37,198 PUBLICATIONS AND GRANTS TO HELP 4439 03:24:37,264 --> 03:24:39,500 CENTER THE NEWSROOM AND AT THE 4440 03:24:39,567 --> 03:24:42,470 HEART OF THE LARGE DATA SETS OR 4441 03:24:42,536 --> 03:24:44,038 CONTROL ACCESS ENVIRONMENT, MANY 4442 03:24:44,105 --> 03:24:46,307 STUDIES WHICH ARE COMPUTING AND 4443 03:24:46,374 --> 03:24:50,645 NOW COMING SOON AS DR. BIANCHI 4444 03:24:50,711 --> 03:24:57,818 MENTIONED WE'RE TRYING TO SHARE 4445 03:24:57,885 --> 03:24:58,252 ANIMAL MODELS. 4446 03:24:58,319 --> 03:24:59,420 WE'RE DOING ALL THIS BY 4447 03:24:59,487 --> 03:25:00,054 LISTENING TO YOU. 4448 03:25:00,121 --> 03:25:10,197 WE WANT TO MAKE SURE IT'S TUNE 4449 03:25:10,264 --> 03:25:11,032 TO THE COMMUNITY AND TO THE 4450 03:25:11,098 --> 03:25:17,438 CONFERENCES WHERE WE WERE LAST 4451 03:25:17,505 --> 03:25:17,705 YEAR. 4452 03:25:17,772 --> 03:25:21,876 THERE'S FOUNDATIONS AND SOME ARE 4453 03:25:21,942 --> 03:25:23,477 GENETIC CONFERENCE AND SOME ARE 4454 03:25:23,544 --> 03:25:25,312 CONFERENCES AIMED AT UNDER 4455 03:25:25,379 --> 03:25:26,981 REPRESENTED MINORITIES. 4456 03:25:27,048 --> 03:25:28,983 AND ANOTHER PART IS MAKING SURE 4457 03:25:29,050 --> 03:25:31,686 WE HAVE A LONG LASTING LEGACY 4458 03:25:31,752 --> 03:25:34,722 THAT WE GET ALL THE DATA PUT IT 4459 03:25:34,789 --> 03:25:38,359 SOMEWHERE SAFE AND TRAIN THE 4460 03:25:38,426 --> 03:25:39,694 NEXT GENERATION OF DIVERSE 4461 03:25:39,760 --> 03:25:41,529 SCIENTISTS AND BENEFIT PEOPLE 4462 03:25:41,595 --> 03:25:47,101 WITHOUT SYNDROME AND SUPPORT NIH 4463 03:25:47,168 --> 03:25:49,804 WE'VE BEEN ABLE TO LAUNCH THE 4464 03:25:49,870 --> 03:25:51,739 RESEARCH AND NOW OFFERED FOR THE 4465 03:25:51,806 --> 03:25:53,874 THIRD TIME THE COMING SUMMER AND 4466 03:25:53,941 --> 03:25:55,176 FUNDING TO OFFER IT FOR MANY 4467 03:25:55,242 --> 03:25:57,278 YEARS TO COME. 4468 03:25:57,344 --> 03:26:01,482 I WOULD LIKE TONED MY PART OF 4469 03:26:01,549 --> 03:26:02,983 THE PRESENTATION BY MAKE SURE 4470 03:26:03,050 --> 03:26:08,823 IT'S A TEAM EFFORT AND MANY 4471 03:26:08,889 --> 03:26:09,457 INDIVIDUALS AND MANY CONTRIBUTES 4472 03:26:09,523 --> 03:26:11,659 TO THE ADMINISTRATION AND 4473 03:26:11,726 --> 03:26:13,260 OUTREACH AND PASS IT NOW TO 4474 03:26:13,327 --> 03:26:16,497 ROBERT CAIRO TO TAKE US INTO THE 4475 03:26:16,564 --> 03:26:17,164 MORE TECHNICAL ASPECTS OF THE 4476 03:26:17,231 --> 03:26:24,171 DATA COMMUNITY. 4477 03:26:24,238 --> 03:26:26,874 >> HI, I'M EXCITED TO SPEAK WITH 4478 03:26:26,941 --> 03:26:27,141 YOU. 4479 03:26:27,208 --> 03:26:28,843 I'M ROBERT CARROLL THE NEW LEAD 4480 03:26:28,909 --> 03:26:32,847 OF THE DATA MANAGEMENT CORPS. 4481 03:26:32,913 --> 03:26:34,048 IT'S A HUGE COLLABORATION ACROSS 4482 03:26:34,115 --> 03:26:35,382 MANY INSTITUTIONS. 4483 03:26:35,449 --> 03:26:38,252 SO WE'RE ALL SUPER EXCITED TO BE 4484 03:26:38,319 --> 03:26:40,221 ABLE TO WORK WITH YOU AND HELP 4485 03:26:40,287 --> 03:26:43,090 IMPROVE THE DATA ECO SYSTEM. 4486 03:26:43,157 --> 03:26:45,259 THE JOURNEY OF A DATA SET IS 4487 03:26:45,326 --> 03:26:47,628 SOMETHING WE TALKED ABOUT WAS 4488 03:26:47,695 --> 03:26:48,662 ALLUDED TO AND SOMETHING 4489 03:26:48,729 --> 03:26:50,331 CRITICAL THEY WANTED TO FOCUS ON 4490 03:26:50,397 --> 03:26:52,600 WITH YOU ALL TODAY. 4491 03:26:52,666 --> 03:26:55,669 OUR GOAL IS TO INCLUDE 4492 03:26:55,736 --> 03:26:56,337 RESEARCHER NEEDS AND THE 4493 03:26:56,403 --> 03:27:03,110 BROADERER RESEARCH COMMUNITY. 4494 03:27:03,177 --> 03:27:08,816 WOE WE WANT TO HELP ALL OF YOU 4495 03:27:08,883 --> 03:27:09,984 IN THOSE AREAS AND WE WANT TO 4496 03:27:10,050 --> 03:27:11,685 GET DATA FROM YOU AND WHAT 4497 03:27:11,752 --> 03:27:13,354 YOU'RE DOING AND SHARING THAT IN 4498 03:27:13,420 --> 03:27:14,388 ANALYSIS WITH THE BROAD RESEARCH 4499 03:27:14,455 --> 03:27:16,490 COMMUNITY. 4500 03:27:16,557 --> 03:27:18,325 OUR GOAL HERE IN THE DATA 4501 03:27:18,392 --> 03:27:20,494 COORDINATING CENTER IS TO BUILD 4502 03:27:20,561 --> 03:27:23,030 THESE REUSABLE CENTERS OF 4503 03:27:23,097 --> 03:27:26,000 SOFTWARE AND WORK WITH ITERATIVE 4504 03:27:26,066 --> 03:27:27,902 PROCESSES AND ACKNOWLEDGING THE 4505 03:27:27,968 --> 03:27:28,869 SHARED RESPONSIBILITY BETWEEN US 4506 03:27:28,936 --> 03:27:31,972 AND YOU TO MAKE THE DATA USEFUL 4507 03:27:32,039 --> 03:27:33,007 AND AVAILABLE TO OTHERS AS WELL 4508 03:27:33,073 --> 03:27:34,608 AS HELPING MAKE SURE THE 4509 03:27:34,675 --> 03:27:35,676 TRACKING IS AVAILABLE AND IT'S 4510 03:27:35,743 --> 03:27:38,379 CLEAR WHAT'S GOING ON AND WHERE 4511 03:27:38,445 --> 03:27:44,919 WE ARE IN THE PROCESSES. 4512 03:27:44,985 --> 03:27:49,323 HOW MANY FEEL OBLIGATED TO SHARE 4513 03:27:49,390 --> 03:27:51,492 YOUR DETE WITH THE NEW DATA 4514 03:27:51,559 --> 03:27:53,627 SHARING MANAGEMENT POLICY? 4515 03:27:53,694 --> 03:27:54,895 HOW MANY FEEL EXCITED TO SHARE 4516 03:27:54,962 --> 03:27:59,667 YOUR DATA? 4517 03:27:59,733 --> 03:28:01,268 THAT'S AWESOME. 4518 03:28:01,335 --> 03:28:03,270 HOW MANY FEEL PREPARED TO SHARE 4519 03:28:03,337 --> 03:28:03,470 DATA? 4520 03:28:03,537 --> 03:28:04,238 NOT AS MANY. 4521 03:28:04,305 --> 03:28:05,973 I THINK THAT'S THE REALITY. 4522 03:28:06,040 --> 03:28:09,243 I'M SO GLAD THIS IS SUCH AN 4523 03:28:09,310 --> 03:28:10,077 ENGAGED COMMUNITY. 4524 03:28:10,144 --> 03:28:11,512 WE'VE GOT SOME BOXES CHECKED BUT 4525 03:28:11,579 --> 03:28:13,681 IT'S CRITICAL WE GET PREPARED 4526 03:28:13,747 --> 03:28:15,216 AND AGAIN THAT'S A SHARED 4527 03:28:15,282 --> 03:28:16,250 JOURNEY AND WHY WE'RE HERE AND 4528 03:28:16,317 --> 03:28:19,653 WHY I'M EXCITED TO WORK WITH YOU 4529 03:28:19,720 --> 03:28:24,024 ALL. 4530 03:28:24,091 --> 03:28:25,726 FAIR IS IMPORTANT AND HAS BEEN 4531 03:28:25,793 --> 03:28:26,760 OUT FOR A WHILE AND NOT 4532 03:28:26,827 --> 03:28:28,162 SOMETHING THAT HAPPENS 4533 03:28:28,229 --> 03:28:28,429 OVERNIGHT. 4534 03:28:28,495 --> 03:28:29,563 IT'S THE SHARED RESPONSIBILITY 4535 03:28:29,630 --> 03:28:31,131 WHERE WE CAN PROVIDE A WEBSITE 4536 03:28:31,198 --> 03:28:32,700 FOR PEOPLE TO FIND DATA BUT WE 4537 03:28:32,766 --> 03:28:37,438 NEED YOUR ENGAGEMENT TO SHARE 4538 03:28:37,504 --> 03:28:38,739 THE STRUCTURED INFORMATION. 4539 03:28:38,806 --> 03:28:40,374 WE HEARD ABOUT THE ANIMAL MODELS 4540 03:28:40,441 --> 03:28:42,810 AND WHAT'S IT LOOK LIKE IS THE 4541 03:28:42,877 --> 03:28:44,378 TYPE OF FEED AND IT'S IMPORTANT 4542 03:28:44,445 --> 03:28:45,946 AND THAT'S SHARED AN STRUCTURED 4543 03:28:46,013 --> 03:28:47,081 WAY. 4544 03:28:47,147 --> 03:28:50,951 WE ALL TOGETHER HAVE WORK TO DO 4545 03:28:51,018 --> 03:28:52,653 TO IMPROVE AND PROVIDE POWERFUL 4546 03:28:52,720 --> 03:28:56,357 TOOLS TO MAKE SURE DATA'S 4547 03:28:56,423 --> 03:28:57,458 FINDABLE. 4548 03:28:57,524 --> 03:28:59,026 SAME WITH PROVIDING SECURED DATA 4549 03:28:59,093 --> 03:29:00,160 SHARING MECHANISM. 4550 03:29:00,227 --> 03:29:01,295 WE CAN HANDLE THE TECHNICAL SIDE 4551 03:29:01,362 --> 03:29:04,832 AND NEED THE ENGAGEMENT ABOUT 4552 03:29:04,899 --> 03:29:06,000 THE CLEAN, CONSISTENT COMPLIANT 4553 03:29:06,066 --> 03:29:06,400 DATA. 4554 03:29:06,467 --> 03:29:07,134 THOSE ARE ALL IMPORTANT. 4555 03:29:07,201 --> 03:29:08,435 THAT'S HALFWAY THROUGH THE 4556 03:29:08,502 --> 03:29:09,970 JOURNEY AND I THINK IT'S 4557 03:29:10,037 --> 03:29:10,704 SOMETHING WE'RE INTERESTED IN 4558 03:29:10,771 --> 03:29:13,807 WORKING WITH YOU ALL TO CONTINUE 4559 03:29:13,874 --> 03:29:16,377 ON TO MAKE IT INTEROPERABLE AND 4560 03:29:16,443 --> 03:29:16,644 REUSABLE. 4561 03:29:16,710 --> 03:29:17,945 SOMETHING WE'VE DONE WELL IS 4562 03:29:18,012 --> 03:29:20,247 PROVIDE THE STANDARDIZED VIEW IN 4563 03:29:20,314 --> 03:29:22,049 THE DATA THROUGH THE PORTAL. 4564 03:29:22,116 --> 03:29:23,884 IT'S A GREAT TOOL SO CHECK IT 4565 03:29:23,951 --> 03:29:24,051 OUT. 4566 03:29:24,118 --> 03:29:26,520 IT REQUIRES A LOT OF INTENSIVE 4567 03:29:26,587 --> 03:29:28,889 WORK AND SOMETHING LIKE WE'LL 4568 03:29:28,956 --> 03:29:30,324 TALK ABOUT WHAT GOES INTO THAT 4569 03:29:30,391 --> 03:29:32,860 PROCESS BUT WE'RE ALSO PLANNING 4570 03:29:32,927 --> 03:29:33,761 TO RENOVATE THIS PROCESS A 4571 03:29:33,827 --> 03:29:35,996 LITTLE BIT TO MAKE IT MORE 4572 03:29:36,063 --> 03:29:37,531 ITERATIVE AND HOPEFULLY SPEED UP 4573 03:29:37,598 --> 03:29:39,533 WHAT WE'RE ABLE TO SHARE. 4574 03:29:39,600 --> 03:29:44,371 THAT'S THE ABRIDGED JOURNEY OF 4575 03:29:44,438 --> 03:29:46,373 DATA SET AND GET IT SHARED MORE 4576 03:29:46,440 --> 03:29:47,675 DIRECTLY INTO THE PORTAL. 4577 03:29:47,741 --> 03:29:49,610 I THINK THAT'S GOING TO BE 4578 03:29:49,677 --> 03:29:52,913 HELPFUL TO MAKING YOUR DATA MORE 4579 03:29:52,980 --> 03:29:54,748 AVAILABLE MORE QUICKLY. 4580 03:29:54,815 --> 03:30:00,321 SOME WORK BEING DONE CURRENTLY 4581 03:30:00,387 --> 03:30:10,931 AND WHILE WE'RE INTEGRATING THEM 4582 03:30:15,803 --> 03:30:16,837 THERE'S NOTHING WRONG WITH 4583 03:30:16,904 --> 03:30:21,342 GETTING DATA OUT MORE QUICKLY. 4584 03:30:21,408 --> 03:30:23,043 SOME MAY HAVE HEARD WE'RE TRYING 4585 03:30:23,110 --> 03:30:25,346 TO COLLECT MORE DATA ABOUT 4586 03:30:25,412 --> 03:30:26,513 STUDIES AND A SUSPECT AFTER THIS 4587 03:30:26,580 --> 03:30:28,048 MEETING WE'LL ENGAGE WITH EVEN 4588 03:30:28,115 --> 03:30:29,817 MORE OF YOU TO GET THAT GOOD 4589 03:30:29,883 --> 03:30:32,419 STRONG STRUCTURED INFORMATION 4590 03:30:32,486 --> 03:30:34,755 ABOUT YOUR STUDY TO START 4591 03:30:34,822 --> 03:30:36,023 SHARING IT AND THE WAND TO 4592 03:30:36,090 --> 03:30:37,091 PROVIDE THE ACCURATE INFORMATION 4593 03:30:37,157 --> 03:30:40,160 ABOUT THE DATA YOU'VE COLLECTED. 4594 03:30:40,227 --> 03:30:41,428 AGAIN, THIS PROCESS WILL BE 4595 03:30:41,495 --> 03:30:42,563 LOOKING DIFFERENT THAN THE PAST. 4596 03:30:42,629 --> 03:30:44,565 WE NEED TO MAKE SURE WE GET 4597 03:30:44,631 --> 03:30:46,266 CLEAN, CONSISTENT STRUCTURED 4598 03:30:46,333 --> 03:30:46,600 DATA FROM YOU. 4599 03:30:46,667 --> 03:30:47,668 THAT WILL BE A FUN AND EXCITING 4600 03:30:47,735 --> 03:30:50,371 PROCESS IN THE FUTURE. 4601 03:30:50,437 --> 03:30:53,707 THAT'S HOW WE CAN EMPOWER OTHER 4602 03:30:53,774 --> 03:31:00,247 RESEARCHERS TO CONNECT AND TON 4603 03:31:00,314 --> 03:31:01,648 DO TO THE POWERFUL WORK. 4604 03:31:01,715 --> 03:31:12,259 WE'RE EXCITED TO ENGAGE AND GET 4605 03:31:16,563 --> 03:31:19,566 THE NUMBERS UP AND GET THE WORK 4606 03:31:19,633 --> 03:31:21,535 OUT TO MORE RESEARCHERS TO 4607 03:31:21,602 --> 03:31:22,703 CONTINUE TO BUILD THE POWERFUL 4608 03:31:22,770 --> 03:31:23,670 ECO SYSTEM DESCRIBED. 4609 03:31:23,737 --> 03:31:25,672 I SEE MANY OF YOU TONIGHT. 4610 03:31:25,739 --> 03:31:27,674 PLEASE REACH OUT AND TALK TO ME 4611 03:31:27,741 --> 03:31:28,642 IT YOU'D LIKE. 4612 03:31:28,709 --> 03:31:31,678 WOULD LOVE TO HEAR WHAT YOU'RE 4613 03:31:31,745 --> 03:31:33,480 WORK ON AND HELP YOU SHARE DATA. 4614 03:31:33,547 --> 03:31:37,051 NOW IT'S MY TURN TO PASS THIS TO 4615 03:31:37,117 --> 03:31:38,886 TALK ABOUT DATA HARMONIZATION 4616 03:31:38,952 --> 03:31:41,889 FOR EMPOWERING ANALYTIC. 4617 03:31:41,955 --> 03:31:43,757 -- ANALYTICS. 4618 03:31:43,824 --> 03:31:46,560 >> HI, IT'S MY GREAT PLEASURE TO 4619 03:31:46,627 --> 03:31:47,261 BE HERE TODAY. 4620 03:31:47,327 --> 03:31:50,264 I'M GOING TRY TO UNPACK A LITTLE 4621 03:31:50,330 --> 03:31:51,965 BIT ABOUT WHAT HAPPENS UNDER THE 4622 03:31:52,032 --> 03:31:54,568 HOOD AT THE DCC AND HOW TO TAKE 4623 03:31:54,635 --> 03:31:56,970 YOUR DATA, MAKE IT MORE 4624 03:31:57,037 --> 03:31:58,238 HARMONIZED AND USEFUL TO MORE 4625 03:31:58,305 --> 03:32:02,776 KINDS OF RESEARCHERS AND MORE 4626 03:32:02,843 --> 03:32:05,179 KINDS OF RESEARCH AND HOPEFULLY 4627 03:32:05,245 --> 03:32:06,880 INSPIRED YOU TO ASK QUESTIONS 4628 03:32:06,947 --> 03:32:08,315 THIS EVENING AND OTHER MEMBERS 4629 03:32:08,382 --> 03:32:11,685 WHO WILL BE HAPPY TO ANSWER YOUR 4630 03:32:11,752 --> 03:32:12,886 QUESTIONS AS WELL. 4631 03:32:12,953 --> 03:32:15,689 SO FIRST, A LITTLE LESSON IN 4632 03:32:15,756 --> 03:32:16,290 DATA MODELLING. 4633 03:32:16,356 --> 03:32:17,991 MY FAVORITE TOPIC. 4634 03:32:18,058 --> 03:32:20,727 SO I JUST WANTED TO HELP 4635 03:32:20,794 --> 03:32:21,295 EVERYBODY UNDERSTAND. 4636 03:32:21,361 --> 03:32:22,396 IT DOESN'T MATTER IF YOU'RE 4637 03:32:22,463 --> 03:32:24,398 DOING A CLINICAL TRIAL OR HAVE 4638 03:32:24,465 --> 03:32:27,201 MODEL ORGANISM DATA OR MAYBE 4639 03:32:27,267 --> 03:32:30,537 HAVE SOME PATIENT GENERATED 4640 03:32:30,604 --> 03:32:30,737 DATA. 4641 03:32:30,804 --> 03:32:33,774 ALL THESE DIFFERENT DATA SOURCES 4642 03:32:33,841 --> 03:32:35,476 FUNDAMENTALLY HAVE CHARACTER 4643 03:32:35,542 --> 03:32:36,777 EFFORTICS WE MIGHT BE ABLE TO 4644 03:32:36,844 --> 03:32:38,245 MODEL IN A CONSISTENT WAY TO 4645 03:32:38,312 --> 03:32:40,047 HELP US ANALYZE THEM ESPECIALLY 4646 03:32:40,114 --> 03:32:41,715 WITHIN THAT KIND OF MODEL BUT 4647 03:32:41,782 --> 03:32:43,650 ALSO IN PARTICULAR ACROSS 4648 03:32:43,717 --> 03:32:45,886 STUDIES. 4649 03:32:45,953 --> 03:32:47,187 WE HAVE INFORMATION WHERE 4650 03:32:47,254 --> 03:32:49,056 INFORMATION IS MODEL DIFFERENTLY 4651 03:32:49,123 --> 03:32:52,526 IN DIFFERENT COHORTS. 4652 03:32:52,593 --> 03:32:54,862 EVERY ONE JUAQUIN PRESENTED HAS 4653 03:32:54,928 --> 03:32:56,663 A DIFFERENT MODEL AND OUR JOB IS 4654 03:32:56,730 --> 03:32:57,965 TO FIGURE OUT HOW TO BRING THEM 4655 03:32:58,031 --> 03:32:58,232 TOGETHER. 4656 03:32:58,298 --> 03:33:04,771 LIKE IF A SAMPLE'S RELATED TO A 4657 03:33:04,838 --> 03:33:05,973 DIAGNOSIS OR CASE INFORMATION 4658 03:33:06,039 --> 03:33:09,576 FOR AN INDIVIDUAL RELATED TO 4659 03:33:09,643 --> 03:33:12,179 THAT DIAGNOSIS. 4660 03:33:12,246 --> 03:33:14,014 THEY'RE DIFFERENT IN DIFFERENT 4661 03:33:14,081 --> 03:33:15,315 DATA DICTIONARIES OR COHORTS. 4662 03:33:15,382 --> 03:33:16,416 IT'S DIFFERENT THAN 4663 03:33:16,483 --> 03:33:18,018 UNDERSTANDING HOW THE DIFFERENT 4664 03:33:18,085 --> 03:33:19,987 COHORTS OR MODEL ORGANISM 4665 03:33:20,053 --> 03:33:22,122 STUDIES MIGHT MODEL DIFFERENT 4666 03:33:22,189 --> 03:33:25,259 ELEMENTS OF THOSE STUDIES. 4667 03:33:25,325 --> 03:33:28,128 FOR EXAMPLE, FOR A COHORT YOU 4668 03:33:28,195 --> 03:33:29,963 MIGHT REPORT RACE WITH THE FOUR 4669 03:33:30,030 --> 03:33:31,632 CATEGORIES AND OTHERS MAY HAVE 4670 03:33:31,698 --> 03:33:32,366 MANY MORE. 4671 03:33:32,432 --> 03:33:35,202 IF WE WANT TO CREATE AN 4672 03:33:35,269 --> 03:33:37,504 INTEGRATIVE DATA SET WE HAVE TO 4673 03:33:37,571 --> 03:33:38,906 DECIDE HOW TO MAP NOT REPORTED 4674 03:33:38,972 --> 03:33:40,174 TO OTHER OR UNKNOWN. 4675 03:33:40,240 --> 03:33:42,576 THOSE ARE NOT THE SAME THING 4676 03:33:42,643 --> 03:33:43,677 THEY WERE COLLECTED IN DIFFERENT 4677 03:33:43,744 --> 03:33:44,011 WAYS. 4678 03:33:44,077 --> 03:33:45,579 WHEN YOU'RE ANALYZING THE DATA 4679 03:33:45,646 --> 03:33:47,581 DOWN STREAM YOU WANT TO KNOW HOW 4680 03:33:47,648 --> 03:33:49,550 IS THAT ALL THAT COLLECTED IN 4681 03:33:49,616 --> 03:33:51,285 ORDER TO NOT GET THE WRONG 4682 03:33:51,351 --> 03:33:51,518 RESULT. 4683 03:33:51,585 --> 03:33:54,121 IT'S A TEDIOUS PROFESSION. 4684 03:33:54,188 --> 03:33:55,389 -- PROCESS. 4685 03:33:55,455 --> 03:33:57,524 WE'VE BEEN DEVELOPING A DATA 4686 03:33:57,591 --> 03:33:58,959 MODEL FOR THE INCLUDE PROJECT 4687 03:33:59,026 --> 03:34:02,429 BASED ON A MODELLING LANGUAGE 4688 03:34:02,496 --> 03:34:04,231 CALLED LINKED ML. 4689 03:34:04,298 --> 03:34:07,334 IT'S LED BY DR. CAN TORRES WHO 4690 03:34:07,401 --> 03:34:12,139 IS ALSO HERE AND WILL BE HAPPY 4691 03:34:12,206 --> 03:34:14,441 TO ANSWER QUESTIONS AND PURETT 4692 03:34:14,508 --> 03:34:16,476 LOW AND SHE'S DONE A LOT OF THE 4693 03:34:16,543 --> 03:34:19,046 WORK AND CAN ANSWER QUESTIONS 4694 03:34:19,112 --> 03:34:19,713 YOU HAVE. 4695 03:34:19,780 --> 03:34:22,983 I JUST WANTED TO MENTION, THIS 4696 03:34:23,050 --> 03:34:26,453 MODELLING LANGUAGE ALLOWS US TO 4697 03:34:26,520 --> 03:34:28,255 ORGANIZE THE KNOWLEDGE ABOUT 4698 03:34:28,322 --> 03:34:29,957 PARTICIPANTS, CO-OCCURRING 4699 03:34:30,023 --> 03:34:30,958 CONDITIONS AND DATA SETS 4700 03:34:31,024 --> 03:34:33,026 ASSOCIATED WITH EACH STUDY. 4701 03:34:33,093 --> 03:34:37,931 SOUNDS SIM FASIMPLE, RIGHT? 4702 03:34:37,998 --> 03:34:40,767 IT'S NOT AN EXAMPLE FROM THE HTP 4703 03:34:40,834 --> 03:34:42,603 DATA SET IN COHORT A AND WE HAVE 4704 03:34:42,669 --> 03:34:44,471 A DIFFERENT ONE IN COHORT B YOU 4705 03:34:44,538 --> 03:34:46,473 CAN SEE WHERE WE'RE LOOKING AT 4706 03:34:46,540 --> 03:34:48,175 THE RACE CATEGORIES ARE 4707 03:34:48,242 --> 03:34:50,410 DIFFERENT ACROSS THE DIFFERENT 4708 03:34:50,477 --> 03:34:50,644 COHORTS. 4709 03:34:50,711 --> 03:34:57,951 I THINK I HAVE A POINTER. 4710 03:34:58,018 --> 03:35:02,089 WE HAVE RACE CATEGORIES ALL 4711 03:35:02,155 --> 03:35:04,524 REPRESENTED DIFFERENTLY AND HERE 4712 03:35:04,591 --> 03:35:13,734 WE LOOK AT THE DEFECT TO WHICH 4713 03:35:13,800 --> 03:35:17,304 APPLY TO A SET OF STRINGS HERE 4714 03:35:17,371 --> 03:35:19,439 THAT HAVE RELATED TERM SHOWN 4715 03:35:19,506 --> 03:35:23,010 HERE INTO ONE SET OF HARMONIZED 4716 03:35:23,076 --> 03:35:29,583 VALUES AND THEN GO INTO THE 4717 03:35:29,650 --> 03:35:31,685 PORTAL AND SEE HOW IT LOOK AT 4718 03:35:31,752 --> 03:35:35,689 THE OTHER END. 4719 03:35:35,756 --> 03:35:39,693 AND THIS TRANSFORMED DATA THEN 4720 03:35:39,760 --> 03:35:42,529 BASICALLY THOSE COHORTS THAT 4721 03:35:42,596 --> 03:35:45,932 HARMONIZATION PROCESS RESULTS IN 4722 03:35:45,999 --> 03:35:49,169 THIS CASE DISEASE ENTITIES OR 4723 03:35:49,236 --> 03:35:50,504 CO-OCCURRING CONDITIONS, 4724 03:35:50,570 --> 03:35:51,638 PHENOTYPIC INFORMATION, RACE 4725 03:35:51,705 --> 03:35:53,173 INFORMATION AND OTHER VARIABLE 4726 03:35:53,240 --> 03:35:56,310 HAVE BEEN HARMONIZED AND YOU CAN 4727 03:35:56,376 --> 03:35:57,878 NAVIGATE THEM WITHIN THE PORTAL. 4728 03:35:57,944 --> 03:36:01,281 OUR GOAL IS TO DO THIS FOR MANY 4729 03:36:01,348 --> 03:36:02,482 MORE VARIABLES AND MAKE THEM 4730 03:36:02,549 --> 03:36:04,618 AVAILABLE WITH THE MULTI-OMICS 4731 03:36:04,685 --> 03:36:14,061 DATA FOR ANALYTICS. 4732 03:36:14,127 --> 03:36:23,170 AND THIS IS A HOW-TO GUIDE AND 4733 03:36:23,236 --> 03:36:24,871 THEY WORK THEY'RE HIERARCHICAL 4734 03:36:24,938 --> 03:36:26,873 IN NATURE AND CLASSIFIED. 4735 03:36:26,940 --> 03:36:29,009 YOU CAN SEE THE NATIONAL OF 4736 03:36:29,076 --> 03:36:31,678 PATIENTS THAT HAVE ABNORMAL 4737 03:36:31,745 --> 03:36:33,413 HEART MORPHOLOGY BUT ANY 4738 03:36:33,480 --> 03:36:36,950 INDIVIDUALS WITH DOWN SYNDROME 4739 03:36:37,017 --> 03:36:38,819 WHO ALSO HAVE SEPTUM MORPHOLOGY 4740 03:36:38,885 --> 03:36:43,523 WOULD BE COUNTED AS PART OF THE 4741 03:36:43,590 --> 03:36:49,796 ABNORMAL MATTER MORE -- 4742 03:36:49,863 --> 03:36:51,164 MORPHOLOGY AND THIS IS WHY IT'S 4743 03:36:51,231 --> 03:36:52,499 IMPORTANT TO HAVE A DATA MODEL 4744 03:36:52,566 --> 03:36:55,669 AND THIS MORNING'S SESSION WAS 4745 03:36:55,736 --> 03:37:01,108 ILLUMINATING IN THE GREAT NEED 4746 03:37:01,174 --> 03:37:04,578 FOR STANDARDIZING RESEARCH DATA 4747 03:37:04,644 --> 03:37:07,581 AND WE HAVE CLINICAL DATA MODEL 4748 03:37:07,647 --> 03:37:13,253 FOR INCLUDE AND FROM THE MONARCH 4749 03:37:13,320 --> 03:37:18,558 INITIATIVE HAVE A BASIC MODEL 4750 03:37:18,625 --> 03:37:29,136 FOR THE STRATEGY ON THE RIGHT 4751 03:37:31,738 --> 03:37:35,142 BETWEEN PHENOTYPES AND THIS IS 4752 03:37:35,208 --> 03:37:38,245 AN EXAMPLE THAT COMES FROM A LAB 4753 03:37:38,311 --> 03:37:40,947 AN THEY'RE HERE TODAY SO YOU CAN 4754 03:37:41,014 --> 03:37:43,650 ASK ABOUT THE WORK BUT USING THE 4755 03:37:43,717 --> 03:37:47,354 BASIC RESEARCH DATA MODEL THAT'S 4756 03:37:47,421 --> 03:37:48,288 BEEN POPULATES WITH BASIC 4757 03:37:48,355 --> 03:37:50,390 RESEARCH DATA AND COMPARE THAT 4758 03:37:50,457 --> 03:37:51,658 TO INFORMATION THAT WE HAVE 4759 03:37:51,725 --> 03:37:55,662 COMING PERFECT THE COHORTS AND 4760 03:37:55,729 --> 03:37:57,898 REPRESENTATIVE USING INCLUDE 4761 03:37:57,964 --> 03:38:08,341 DATA MODEL TO LOOK AT 4762 03:38:09,409 --> 03:38:10,277 CILIOPATHIES AND THIS IS A 4763 03:38:10,343 --> 03:38:12,679 PRELIMINARY EXAMPLE OF TRYING TO 4764 03:38:12,746 --> 03:38:14,481 EXERCISE HOW WE CAN USE TO THE 4765 03:38:14,548 --> 03:38:16,483 DATA MODELS TO ALIGN THE BASIC 4766 03:38:16,550 --> 03:38:23,657 RESEARCH DATA WITH THE CLINICAL 4767 03:38:23,723 --> 03:38:34,267 DATA AND WITH THAT I'LL HAND IT 4768 03:38:35,569 --> 03:38:35,669 OFF. 4769 03:38:35,735 --> 03:38:44,010 >> THANK YOU. 4770 03:38:44,077 --> 03:38:52,486 I'M AND I'M WITH THE CHILDREN'S 4771 03:38:52,552 --> 03:38:53,353 HOSPITAL, PHILADELPHIA. 4772 03:38:53,420 --> 03:38:55,655 THE DATA PORTAL IS MEANT TO BE A 4773 03:38:55,722 --> 03:38:56,189 COMPREHENSIVE DISCOVERY 4774 03:38:56,256 --> 03:38:56,523 PLATFORM. 4775 03:38:56,590 --> 03:39:01,728 THE FIRST MISSION IS TO MAKE ALL 4776 03:39:01,795 --> 03:39:04,998 THE DATA ACCESSIBLE. 4777 03:39:05,065 --> 03:39:06,967 THERE'S MODALITIES AND SOURCES 4778 03:39:07,033 --> 03:39:09,536 OF DATA THAT WE RECEIVE FROM THE 4779 03:39:09,603 --> 03:39:15,675 DOWN SYNDROME STUDY PARTICIPANT 4780 03:39:15,742 --> 03:39:19,646 IN THE PROGRAM INTO A SINGLE 4781 03:39:19,713 --> 03:39:30,090 UNIFIED DAT PLATFORM. 4782 03:39:30,290 --> 03:39:35,662 I HAVE ONLY MINUTES TO PARENT 4783 03:39:35,729 --> 03:39:37,297 THE SOFTWARE. 4784 03:39:37,364 --> 03:39:41,401 I'LL INTRODUCE FOUR DATA 4785 03:39:41,468 --> 03:39:47,007 DISCOVERY TOOLS AND THE STUDY 4786 03:39:47,073 --> 03:39:57,617 REPOSITORY AND THE BIO EXPLORER. 4787 03:40:05,992 --> 03:40:11,264 THE CORD BUILDER IS THE TOO MANY 4788 03:40:11,331 --> 03:40:15,435 THAT LEVERAGES OUR EFFORTS IN 4789 03:40:15,502 --> 03:40:16,102 DATA ORGANIZATION. 4790 03:40:16,169 --> 03:40:18,672 IN THIS SEARCHING OF DATA ACROSS 4791 03:40:18,738 --> 03:40:21,474 MULTIPLE STUDIES AND BUILDING OF 4792 03:40:21,541 --> 03:40:31,885 PARTS FROM MULTIPLE STUDIES. 4793 03:40:31,952 --> 03:40:37,557 AND THERE'S A COHORTS YOU CAN 4794 03:40:37,624 --> 03:40:38,592 SEARCH. 4795 03:40:38,658 --> 03:40:43,563 ON THE LEFT YOU SEARCH CRITERIA 4796 03:40:43,630 --> 03:40:44,864 RELATES TO BIO PARTICIPANT AND 4797 03:40:44,931 --> 03:40:47,167 DATA FILES AND WITH THESE YOU 4798 03:40:47,233 --> 03:40:49,135 CAN FORMULATE COMPLEX QUERIES. 4799 03:40:49,202 --> 03:40:52,005 FOR EXAMPLE, I HAVE A QUERY THAT 4800 03:40:52,072 --> 03:40:59,012 CAN BE READ AS FINDING ALL THE 4801 03:40:59,079 --> 03:41:07,687 TRISOMIC PARTS ANDAGE WE HAVE 4802 03:41:07,754 --> 03:41:13,994 GENE EXPRESSION DATA. 4803 03:41:14,060 --> 03:41:16,162 WE HAVE DIFFERENT QUERY. 4804 03:41:16,229 --> 03:41:22,102 THEY CAN KIND THEM AND SAVE THEM 4805 03:41:22,168 --> 03:41:28,875 NAY WANT TO CHECK IF THERE'S NEW 4806 03:41:28,942 --> 03:41:38,618 IN THE COHORT. 4807 03:41:38,685 --> 03:41:43,023 THERE'S THE RESULT IS THE 4808 03:41:43,089 --> 03:41:46,593 SUMMARY VIEW THE GRID 4809 03:41:46,660 --> 03:41:47,193 CUSTOMIZABLE WITH INTERACTIVE 4810 03:41:47,260 --> 03:41:54,834 CHARGE IMMIGRATION. 4811 03:41:54,901 --> 03:42:02,575 -- AGGREGATION WE HAVE BUILT 4812 03:42:02,642 --> 03:42:05,078 THIS ONTOLOGY BROWSERS SO THE 4813 03:42:05,145 --> 03:42:10,183 ENTIRETY OF TERMS FOR THE HPU 4814 03:42:10,250 --> 03:42:13,653 AND ONTOLOGY AND TOGETHER WITH 4815 03:42:13,720 --> 03:42:14,587 ON THE RIGHT SIDE COUNTS FOR 4816 03:42:14,654 --> 03:42:19,559 EACH AND SUB NOTE. 4817 03:42:19,626 --> 03:42:22,996 AND THE SEARCH ENGINE WILL 4818 03:42:23,063 --> 03:42:28,668 RETURN PARTS WITH THIS EXACTER 4819 03:42:28,735 --> 03:42:36,076 BUT ALSO THE PARTS WITH THE TAG 4820 03:42:36,142 --> 03:42:39,679 UNDER THE SUB NOTE AND TERM 4821 03:42:39,746 --> 03:42:42,882 SELECTED. 4822 03:42:42,949 --> 03:42:44,784 THIS IS OUR WAY TO DIFFERENT 4823 03:42:44,851 --> 03:42:47,687 WITH A DEAL LEVEL OF PRECISION 4824 03:42:47,754 --> 03:42:50,290 ACROSS COHORT. 4825 03:42:50,356 --> 03:42:53,693 THERE'S THE PARTS PANEL VIEW AND 4826 03:42:53,760 --> 03:42:55,428 THE TABLE THE PARTICIPANTS THAT 4827 03:42:55,495 --> 03:42:59,532 WILL MEET THE CRITERIA. 4828 03:42:59,599 --> 03:43:00,834 SO EACH REPRESENT A PARTICIPANT 4829 03:43:00,900 --> 03:43:10,910 WITH THE CLINICAL DATA OR THE 4830 03:43:10,977 --> 03:43:15,315 YOU HAVE THE BIO SPECIMEN AND WE 4831 03:43:15,381 --> 03:43:19,853 HAVE COUNTS LINKED TO EACH 4832 03:43:19,919 --> 03:43:20,553 PARTICIPANT. 4833 03:43:20,620 --> 03:43:23,690 IT GIVES A SENSE OF AVAILABLE 4834 03:43:23,757 --> 03:43:30,096 RESOURCES FOR INVESTIGATION. 4835 03:43:30,163 --> 03:43:35,201 THE THIRD IS A TABLE OF FIVES 4836 03:43:35,268 --> 03:43:36,936 AND SO NICE THING WITH THE VIEW 4837 03:43:37,003 --> 03:43:38,605 IT'S FULLY INTEGRATED TO THE 4838 03:43:38,671 --> 03:43:44,511 PLATFORM. 4839 03:43:44,577 --> 03:43:46,846 IT MEANS FOR EXAMPLE FOR 4840 03:43:46,913 --> 03:43:48,848 INSTANCE IN THIS EXAMPLE THE 4841 03:43:48,915 --> 03:43:53,286 LIST OF FIVES WOULD BE THE GENE 4842 03:43:53,353 --> 03:43:55,822 EXPRESSION IDENTIFIED THAT WE 4843 03:43:55,889 --> 03:44:06,099 HAVE FOUND. 4844 03:44:06,633 --> 03:44:08,668 AND THEY CAN TRANSFER THEM TO 4845 03:44:08,735 --> 03:44:11,671 THE PRIVATE WORK SPACE ON THE 4846 03:44:11,738 --> 03:44:14,174 CLOUD. 4847 03:44:14,240 --> 03:44:18,011 WE'LL TALK MORE ABOUT THE 4848 03:44:18,077 --> 03:44:18,311 PLATFORM. 4849 03:44:18,378 --> 03:44:21,848 INTEREST TRANSFERRING THIS? 4850 03:44:21,915 --> 03:44:24,617 IT'S FOR DOING FURTHER 4851 03:44:24,684 --> 03:44:33,059 STATISTICAL OR BIO INFORMATIC 4852 03:44:33,126 --> 03:44:33,326 ANALYSIS. 4853 03:44:33,393 --> 03:44:33,626 T 4854 03:44:33,693 --> 03:44:37,096 IT ENABLE THE SEARCHING OF BIO 4855 03:44:37,163 --> 03:44:38,498 SPECIMEN AND PERMISSION OF 4856 03:44:38,565 --> 03:44:40,767 REQUESTS TO THE BIO BANK. 4857 03:44:40,834 --> 03:44:43,670 IT'S A TABLE OF BIO SPECIMEN 4858 03:44:43,736 --> 03:44:48,208 THAT MEET THE SEARCH CRITERIA 4859 03:44:48,274 --> 03:44:55,648 AND THE RESEARCHER COULD SELECT 4860 03:44:55,715 --> 03:44:59,385 THEM AND HAVE A REPORT SUBMITTED 4861 03:44:59,452 --> 03:45:04,090 TO EACH BIO BANK IN THE SPLENGS 4862 03:45:04,157 --> 03:45:05,258 CURRENTLY, INCLUDE THE IT DATA 4863 03:45:05,325 --> 03:45:10,964 WE HAVE 25,000 MORE THAN 25,000 4864 03:45:11,030 --> 03:45:13,066 SAMPLES FOR WHICH WE HAVE THE 4865 03:45:13,132 --> 03:45:14,500 TYPE AND LABORATORY PROCESSOR 4866 03:45:14,567 --> 03:45:19,639 AND LINEAGE FROM THE FIRST 4867 03:45:19,706 --> 03:45:21,307 COLLECTION THERE THE PARTICIPANT 4868 03:45:21,374 --> 03:45:25,111 TO THE GENE EDITING CODE SO A 4869 03:45:25,178 --> 03:45:26,613 LOT OF INFORMATION THAT CAN BE 4870 03:45:26,679 --> 03:45:34,387 MADE AVAILABLE TO THE PORTAL. 4871 03:45:34,454 --> 03:45:37,090 ANOTHER TOOL IS THE STUDY 4872 03:45:37,156 --> 03:45:37,523 REPOSITORY. 4873 03:45:37,590 --> 03:45:39,525 IT'S A SEARCHABLE CATALOG OF 4874 03:45:39,592 --> 03:45:41,794 STUDIES AND DATA SETS. 4875 03:45:41,861 --> 03:45:46,799 SO THESE STUDIES AND DATA SETS 4876 03:45:46,866 --> 03:45:49,335 CAN BE SEARCHED USING DIFFERENT 4877 03:45:49,402 --> 03:45:49,969 CRITERIA AND THE RESEARCH AND 4878 03:45:50,036 --> 03:45:59,279 DATA SOURCE AND SO ON. 4879 03:45:59,345 --> 03:46:02,649 THOUGH IT LOOKS SIMPLE IT PLAYS 4880 03:46:02,715 --> 03:46:05,985 A MAJOR ROLE IN THE COMING 4881 03:46:06,052 --> 03:46:06,286 YEARS. 4882 03:46:06,352 --> 03:46:10,223 IT INCLUDES NOT ONLY HARMONIZED 4883 03:46:10,290 --> 03:46:12,225 DATA BUT NUMEROUS STUDIES AND 4884 03:46:12,292 --> 03:46:16,629 THEIR DATA SET. 4885 03:46:16,696 --> 03:46:18,531 IT'S A WAY FOR STUDIES THAT ARE 4886 03:46:18,598 --> 03:46:22,468 NOT HARMONIZED YET SO IT'S A NEW 4887 03:46:22,535 --> 03:46:29,008 TYPE OF DATA THAT WILL MAKE IT 4888 03:46:29,075 --> 03:46:39,619 DISCOVERABLE AND THIS IS THERE'S 4889 03:46:44,791 --> 03:46:46,259 A STUDY PAGE WITH A LOT OF 4890 03:46:46,326 --> 03:46:47,794 INFORMATION WE LAUNCHED LAST 4891 03:46:47,860 --> 03:46:48,094 WEEK. 4892 03:46:48,161 --> 03:46:48,962 A LOT OF INFORMATION CAN BE 4893 03:46:49,028 --> 03:46:57,737 FOUND ON THE STUDY PAGE AND NE 4894 03:46:57,804 --> 03:46:59,138 PRINCIPLE INVESTIGATORS AND 4895 03:46:59,205 --> 03:47:01,441 SUMMARIES AND DATA ACCESS 4896 03:47:01,507 --> 03:47:04,010 POLICIES AND ALSO SOME FUTURE 4897 03:47:04,077 --> 03:47:05,745 DATA SETS THAT ARE MAYBE 4898 03:47:05,812 --> 03:47:07,280 REFERRED TO BY PUBLICATION AND 4899 03:47:07,347 --> 03:47:07,747 OTHER INFORMATION. 4900 03:47:07,814 --> 03:47:16,823 ALL THIS IN A SINGLE PAGE VERY 4901 03:47:16,889 --> 03:47:18,524 CONVENIENT AND WILL HELP RELEASE 4902 03:47:18,591 --> 03:47:19,492 DATA FASTER. 4903 03:47:19,559 --> 03:47:21,661 THE LAST TWO I'D LIKE TO TALK 4904 03:47:21,728 --> 03:47:23,930 ABOUT IS THE EXPLORER. 4905 03:47:23,997 --> 03:47:27,633 SO THIS TOOL ENABLED THE SEARCH 4906 03:47:27,700 --> 03:47:31,304 ACROSS MILLIONS OF VARIANTS WITH 4907 03:47:31,371 --> 03:47:33,873 NO CURRENT CONDITIONS. 4908 03:47:33,940 --> 03:47:42,548 SO WHAT WE DO IS THE FOLLOWING. 4909 03:47:42,615 --> 03:47:45,985 AND THERE'S VARIANTS IN VCF FIVE 4910 03:47:46,052 --> 03:47:47,387 A TECHNICAL TERM THEY'LL 4911 03:47:47,453 --> 03:47:51,257 VARIANTS ARE PRODUCED IN FILES 4912 03:47:51,324 --> 03:47:59,699 AND EX TRACT THEM AND ANNOTATE 4913 03:47:59,766 --> 03:48:05,605 THEM IN A DATABASE AND SEARCH 4914 03:48:05,671 --> 03:48:12,145 LIKE THE CORD BUILDER WITH 4915 03:48:12,211 --> 03:48:14,747 FREQUENCIES AND YOU GET A LIST 4916 03:48:14,814 --> 03:48:17,683 OF VARIANTS WITH THE MOST 4917 03:48:17,750 --> 03:48:18,985 CONSEQUENCE AND THEN YOU HAVE 4918 03:48:19,052 --> 03:48:20,753 ALSO THE FREQUENCY WITHIN THE 4919 03:48:20,820 --> 03:48:24,223 INCLUDE COHORT WITHIN EACH STUDY 4920 03:48:24,290 --> 03:48:25,758 AND WHEN THE VARIANTS PRESENT IN 4921 03:48:25,825 --> 03:48:27,760 MORE THAN 10 YOU HAVE A LINK AND 4922 03:48:27,827 --> 03:48:30,630 YOU CAN GET THE LIST FROM THE 4923 03:48:30,696 --> 03:48:35,001 CORD BUILDER OF THE PARTICIPANT 4924 03:48:35,068 --> 03:48:37,703 THAT CARRY THESE VARIANT. 4925 03:48:37,770 --> 03:48:39,005 CURRENTLY WE HAVE 74 MILLION 4926 03:48:39,072 --> 03:48:39,772 VARIANT INTERESTS TWO STUDIES IN 4927 03:48:39,839 --> 03:48:42,275 OUR DATABASE. 4928 03:48:42,341 --> 03:48:47,780 SO EACH VARIANT WE HAVE A 4929 03:48:47,847 --> 03:48:52,652 VARIANT PAGE AND IT'S A NEW ONE 4930 03:48:52,718 --> 03:48:53,486 LAUNCHED LAST WEEK CONTAINING 4931 03:48:53,553 --> 03:48:55,188 ALL THE INFORMATION YOU CAN GET 4932 03:48:55,254 --> 03:48:55,922 FROM A VARIANT. 4933 03:48:55,988 --> 03:48:59,659 ALL THE FREQUENCIES AND ALL THE 4934 03:48:59,725 --> 03:49:03,663 ANNOTATION AND THE GENE TO 4935 03:49:03,729 --> 03:49:05,498 PHENOTYPE CESSATION AND WITH ODD 4936 03:49:05,565 --> 03:49:08,568 AND OTHER INFORMATION. 4937 03:49:08,634 --> 03:49:11,537 SO THE FUTURE WORK AND SO I 4938 03:49:11,604 --> 03:49:14,774 THINK WE'LL KEEP OVER THE NEXT 4939 03:49:14,841 --> 03:49:17,110 YEAR WE'LL KEEP IMPROVING WHAT 4940 03:49:17,176 --> 03:49:18,111 WE'LL SHOW YOU. 4941 03:49:18,177 --> 03:49:20,680 IT MEANS THE DATA DISCOVERY SIDE 4942 03:49:20,746 --> 03:49:24,484 AND BUT WE WANT TO GO START AT 4943 03:49:24,550 --> 03:49:29,755 THE NEXT PHASE TO INTRODUCE MORE 4944 03:49:29,822 --> 03:49:31,324 DATA. 4945 03:49:31,390 --> 03:49:36,028 SO WE'LL HAVE DATA TOOLS LIKE 4946 03:49:36,095 --> 03:49:37,196 GENE EXPRESSION AND COMPARISON 4947 03:49:37,263 --> 03:49:40,566 AND WANT ALSO TO DEVELOP THIS 4948 03:49:40,633 --> 03:49:42,268 LONGITUDINAL VIEW OF THE 4949 03:49:42,335 --> 03:49:43,836 CLINICAL DATA FOR THE 4950 03:49:43,903 --> 03:49:44,137 PARTICIPANT. 4951 03:49:44,203 --> 03:49:46,272 THIS IS WHAT WE'RE GOING TO WORK 4952 03:49:46,339 --> 03:49:48,141 ON OVER THE NEXT YEARS AND ALL 4953 03:49:48,207 --> 03:49:51,511 THIS IS INTEGRATED IN A 4954 03:49:51,577 --> 03:49:52,812 DASHBOARD I DIDN'T HAVE THE TIME 4955 03:49:52,879 --> 03:49:55,047 TO PRESENT BUT WOULD BE A VERY 4956 03:49:55,114 --> 03:50:05,391 EASY TO ACCESS. 4957 03:50:19,238 --> 03:50:20,940 >> I KNOW THERE'S BEEN COMPLEX 4958 03:50:21,007 --> 03:50:22,108 STEPS THAT HAVE BEEN DESCRIBED. 4959 03:50:22,175 --> 03:50:24,677 WE TRIED TO CAPTURE THIS IN AS 4960 03:50:24,744 --> 03:50:25,378 FEW NUMBER OF SLIDES. 4961 03:50:25,444 --> 03:50:28,648 REACH OUT TO US IF YOU WE HAVE 4962 03:50:28,714 --> 03:50:32,018 GLOSSED OVER AND I WILL GLOSS 4963 03:50:32,084 --> 03:50:37,557 OVER TEAMS BUT TO SHOW YOU THE 4964 03:50:37,623 --> 03:50:43,663 JOURNEY THE TEAM ROBERT STARTED 4965 03:50:43,729 --> 03:50:43,863 WITH. 4966 03:50:43,930 --> 03:50:47,433 IT'S NOT THE LAST STEP AND IT'S 4967 03:50:47,500 --> 03:50:50,269 A PLACE WE'D LIKE TO YOU DO 4968 03:50:50,336 --> 03:50:55,308 CLOUD ANALYSIS AND BRING DATA 4969 03:50:55,374 --> 03:51:00,079 SETS THAT EXIST AND MOVE IT OUT 4970 03:51:00,146 --> 03:51:01,214 AND PROVIDE YOUR LAPTOP AND 4971 03:51:01,280 --> 03:51:06,919 WHERE YOU NEED TO TAKE THE DATA. 4972 03:51:06,986 --> 03:51:10,022 THE IDEA IS AND WHEN YOU THINK 4973 03:51:10,089 --> 03:51:14,594 OF THE CLOUD YOU THINK OF A WAY 4974 03:51:14,660 --> 03:51:15,895 TO INTEGRATE RESOURCES CHEAPLY, 4975 03:51:15,962 --> 03:51:17,730 FASTER IN A WAY THAT COULD NOT 4976 03:51:17,797 --> 03:51:18,564 BE DONE BEFORE. 4977 03:51:18,631 --> 03:51:19,332 IF THAT DOESN'T MAKE SENSE 4978 03:51:19,398 --> 03:51:29,108 PLEASE TALK TO ME. 4979 03:51:29,175 --> 03:51:32,111 AND THIS IS AGNOSTIC IF YOU 4980 03:51:32,178 --> 03:51:35,648 THINK BIT. 4981 03:51:35,715 --> 03:51:38,050 WE WOULD LIKE USERS AND WE WANT 4982 03:51:38,117 --> 03:51:39,085 TO YOU THINK ABOUT THE CLOUD AS 4983 03:51:39,151 --> 03:51:41,187 AN ASSET. 4984 03:51:41,254 --> 03:51:44,156 YOU CAN COLLABORATE AND REUSE 4985 03:51:44,223 --> 03:51:47,426 AND MAKE YOUR DATA USABLE, 4986 03:51:47,493 --> 03:51:49,562 REPRODUCIBLE AND EXTENDIBLE AND 4987 03:51:49,629 --> 03:51:50,429 SCALABLE AT COMPUTE. 4988 03:51:50,496 --> 03:51:53,833 THESE ARE NOT BUZZ WORDS BUT TRY 4989 03:51:53,899 --> 03:51:56,902 TO TOUCH ON THIS IN DIFFERENT 4990 03:51:56,969 --> 03:52:00,973 USER PERSONA. 4991 03:52:01,040 --> 03:52:04,777 THE VALUE THAT COMES IN IS ALL 4992 03:52:04,844 --> 03:52:06,479 THE OTHER CONSORTIUMS USING THE 4993 03:52:06,545 --> 03:52:07,680 PLATFORM AND YOU'LL LIKELY GET 4994 03:52:07,747 --> 03:52:09,615 ACCESS TO THE DATA SETS. 4995 03:52:09,682 --> 03:52:11,784 WHY'S THAT IMPORTANT? 4996 03:52:11,851 --> 03:52:15,454 SO FOR EXAMPLE, CONSIDER 4997 03:52:15,521 --> 03:52:19,659 CAVATICA WE'RE HERE FOR THE 4998 03:52:19,725 --> 03:52:21,193 INCLUDE CONSORTIUM BUT IT'S 4999 03:52:21,260 --> 03:52:23,296 CONNECTED TO OTHER DATA SETS 5000 03:52:23,362 --> 03:52:28,968 LIKE PUB MED AND OTHER DATA SETS 5001 03:52:29,035 --> 03:52:31,971 AND EVERYTHING LIKE TCGA AND YOU 5002 03:52:32,038 --> 03:52:33,973 CAN BE PROVIDED WITHOUT COPYING 5003 03:52:34,040 --> 03:52:43,749 IT. 5004 03:52:43,816 --> 03:52:46,485 YOU CAN START USING IT ON 5005 03:52:46,552 --> 03:52:47,887 CAVATICA WITHOUT PAYING ANYTHING 5006 03:52:47,953 --> 03:52:48,921 FOR STORAGE WHICH MEANS A LOT AS 5007 03:52:48,988 --> 03:52:56,128 YOU SCALE UP YOUR COMPUTE. 5008 03:52:56,195 --> 03:53:00,966 AND THERE'S AUTHENTICATION 5009 03:53:01,033 --> 03:53:03,803 REQUIRED FOR CERTAIN DATA SETS. 5010 03:53:03,869 --> 03:53:08,908 SO THESE ARE DIFFERENT PERSONAS. 5011 03:53:08,974 --> 03:53:11,344 SO WHY ARE THE CLOUD COMPUTE 5012 03:53:11,410 --> 03:53:11,911 PLATFORM USEFUL? 5013 03:53:11,977 --> 03:53:14,914 THINK OF THIS AS A FLOW. 5014 03:53:14,980 --> 03:53:16,015 ADMINISTRATORS WHO ARE PROVIDING 5015 03:53:16,082 --> 03:53:17,583 FUNDING WOULD LIKE TO KNOW HOW 5016 03:53:17,650 --> 03:53:22,321 IT'S BEING USED BY DIFFERENT 5017 03:53:22,388 --> 03:53:23,856 RESEARCHERS. 5018 03:53:23,923 --> 03:53:24,757 MATHEMATICIANS CAN PRODUCE THOSE 5019 03:53:24,824 --> 03:53:26,459 AND GIVE IT TO THE BENCH 5020 03:53:26,525 --> 03:53:28,127 SCIENTIST TO PLUG IT IN AND TAKE 5021 03:53:28,194 --> 03:53:30,529 REPORTS FROM IT AND GIVE THAT TO 5022 03:53:30,596 --> 03:53:32,798 A CLINICIAN AND THEN ONCE 5023 03:53:32,865 --> 03:53:34,533 EVERYBODY'S HAPPY WITH THE 5024 03:53:34,600 --> 03:53:36,669 PROTOTYPE BUILT IT CAN BE 5025 03:53:36,736 --> 03:53:38,537 PRODUCTIONIZED AND MADE SCALABLE 5026 03:53:38,604 --> 03:53:40,339 AND NOW THE BUZZ WORDS COME BACK 5027 03:53:40,406 --> 03:53:41,140 AND MADE MORE SCALABLE BY 5028 03:53:41,207 --> 03:53:46,445 DEVELOPERS. 5029 03:53:46,512 --> 03:53:48,314 YOU CAN LOOK AT DIFFERENT 5030 03:53:48,381 --> 03:53:49,482 PERSONAS WHO IN OTHER WAYS HAVE 5031 03:53:49,548 --> 03:53:51,584 TO GO THROUGH DIFFERENT 5032 03:53:51,650 --> 03:53:52,952 PROCESSES AND WORK TOGETHER IN 5033 03:53:53,018 --> 03:54:02,695 THE SAME ECO SYSTEM. 5034 03:54:02,762 --> 03:54:10,069 AND YOU CAN HAVE MULTIPLE USERS 5035 03:54:10,136 --> 03:54:11,604 I WON'T GO INTO DETAIL BUT YOU 5036 03:54:11,670 --> 03:54:13,906 THINK OF IT AS A CLOUD WORK 5037 03:54:13,973 --> 03:54:15,107 SPACE WHERE YOU CAN PUT YOUR 5038 03:54:15,174 --> 03:54:17,343 DATA ACCESS AND OTHER TEAM'S 5039 03:54:17,410 --> 03:54:23,416 DATA AND SHARE YOUR DATA WITH 5040 03:54:23,482 --> 03:54:26,786 SELECTIVE COLLABORATORS, 5041 03:54:26,852 --> 03:54:29,822 STUDENTS, YOU DECIDE WHO. 5042 03:54:29,889 --> 03:54:31,657 SO YOU CAN USE DIFFERENT WORK 5043 03:54:31,724 --> 03:54:34,660 FLOW LANGUAGES WHICH ARE 5044 03:54:34,727 --> 03:54:37,229 LANGUAGES IN WHICH YOU WRITE 5045 03:54:37,296 --> 03:54:40,366 PIPELINES AND THE FLOW AND USERS 5046 03:54:40,433 --> 03:54:41,934 OF BOTH IN THE ROOM. 5047 03:54:42,001 --> 03:54:44,470 R STUDIO AND SUPER TER ARE TWO 5048 03:54:44,537 --> 03:54:46,605 OF THE MOST COMMONLY INTERACTIVE 5049 03:54:46,672 --> 03:54:48,174 PROGRAMMING TOOLS WHICH YOU CAN 5050 03:54:48,240 --> 03:54:49,608 USE AND THEN OF COURSE ONCE 5051 03:54:49,675 --> 03:54:51,877 YOU'RE HAPPY WITH THAT TOOLING 5052 03:54:51,944 --> 03:54:55,848 YOU CAN CREATE WEB APPLICATIONS. 5053 03:54:55,915 --> 03:54:59,652 I WANT TO TAKE A SECOND TO TALK 5054 03:54:59,718 --> 03:55:10,262 ABOUT JUPYTER AND R STUDIO AND 5055 03:55:12,331 --> 03:55:15,468 YOU CAN MOVE IT TO JUPYTER LAB 5056 03:55:15,534 --> 03:55:19,071 AND R STUDIO IN THE CLOUD THEY 5057 03:55:19,138 --> 03:55:21,607 CAN USE IT WITHOUT COPYING IT. 5058 03:55:21,674 --> 03:55:23,576 THAT MAY BE USEFUL. 5059 03:55:23,642 --> 03:55:29,515 THIS IS A QUICK SNAPSHOT. 5060 03:55:29,582 --> 03:55:33,819 START FROM THE PORTAL YOU CLICK 5061 03:55:33,886 --> 03:55:34,820 AND THE BUTTON. 5062 03:55:34,887 --> 03:55:37,389 THIS MEANS THE FILES ARE NOT 5063 03:55:37,456 --> 03:55:40,826 COPIED TO CAVATICA ONLY THE 5064 03:55:40,893 --> 03:55:41,227 POINTERS. 5065 03:55:41,293 --> 03:55:43,229 YOU'RE NOT PAYING ANYTHING FOR 5066 03:55:43,295 --> 03:55:43,462 STORAGE. 5067 03:55:43,529 --> 03:55:46,365 YOU CAN PLUG IN DATA AND SOME 5068 03:55:46,432 --> 03:55:48,300 TODAY IS AUTOMATICALLY 5069 03:55:48,367 --> 03:55:48,567 POPULATED. 5070 03:55:48,634 --> 03:55:51,203 YOU CAN ANALYZE IT OR CONNECT TO 5071 03:55:51,270 --> 03:55:52,905 OUR METADATA SERVER CALLED THE 5072 03:55:52,972 --> 03:55:53,372 FIRE SERVER. 5073 03:55:53,439 --> 03:55:54,773 YOU DON'T HAVE TO WORRY ABOUT 5074 03:55:54,840 --> 03:55:56,141 DATA AT THIS POINT. 5075 03:55:56,208 --> 03:56:00,312 YOU CAN BRING ALL OF IT TOGETHER 5076 03:56:00,379 --> 03:56:02,181 IN A WORK FLOW AND GET YOUR 5077 03:56:02,248 --> 03:56:03,315 SCIENTIFIC ANALYSIS DONE. 5078 03:56:03,382 --> 03:56:04,717 THIS IS THE JOURNEY FROM 5079 03:56:04,783 --> 03:56:07,286 SEARCHING FOR THE DATA AND THE 5080 03:56:07,353 --> 03:56:10,689 NEED OF CAVATICA AND DOING IT 5081 03:56:10,756 --> 03:56:14,860 ALL IN THE CLOUD USING CLOUD 5082 03:56:14,927 --> 03:56:16,529 CREDIT. 5083 03:56:16,595 --> 03:56:19,665 SO, TODAY YOU CAN GO IN. 5084 03:56:19,732 --> 03:56:21,901 ANYBODY CAN CREATE A LOG IN IN 5085 03:56:21,967 --> 03:56:23,802 THE E-MAIL AND YOU CAN GET 5086 03:56:23,869 --> 03:56:26,205 HUNDRED DOLLARS OF CLOUD CREDIT 5087 03:56:26,272 --> 03:56:29,441 TO PAY IN THE PLATFORM. 5088 03:56:29,508 --> 03:56:31,677 WE HAVE A SIMPLE CLOUD CREDIT 5089 03:56:31,744 --> 03:56:32,778 APPLICATION PROGRAM WHICH IS AN 5090 03:56:32,845 --> 03:56:35,314 E-MAIL TO A FRIENDLY GROUP OF 5091 03:56:35,381 --> 03:56:37,850 PEOPLE TO GET ANALYSIS AND WE 5092 03:56:37,917 --> 03:56:39,184 CAN KEEP ON WORKING WOULD 5093 03:56:39,251 --> 03:56:41,554 SCALING THAT UP. 5094 03:56:41,620 --> 03:56:43,689 WE HAVE MEANS TO HELP YOU BUILD 5095 03:56:43,756 --> 03:56:48,694 WORK FLOWS AND UNDERSTAND WHAT 5096 03:56:48,761 --> 03:56:50,963 ALL THE TECHNOLOGY MEANS AND 5097 03:56:51,030 --> 03:56:54,633 THERE'S A QR CODE AND I POSTER 5098 03:56:54,700 --> 03:56:55,334 UP THERE. 5099 03:56:55,401 --> 03:56:59,138 IT TALKS ABOUT IT MORE AND HAVE 5100 03:56:59,204 --> 03:57:00,739 QUESTIONS TALK KNOW AND ASK ME 5101 03:57:00,806 --> 03:57:03,008 WHY YOU SHOULD THINK ABOUT CLOUD 5102 03:57:03,075 --> 03:57:03,442 COMPUTE. 5103 03:57:03,509 --> 03:57:05,144 WE'D LIKE TO HELP YOU MAKE THE 5104 03:57:05,210 --> 03:57:06,445 TRANSITION IF YOU THINK IT'S GAI 5105 03:57:06,512 --> 03:57:08,447 IDEA AND NEXT DR. RESNIK WILL 5106 03:57:08,514 --> 03:57:19,024 COME IN AND CLOSE THE SESSION. 5107 03:57:21,627 --> 03:57:24,897 MY JOB IS TO BE THE CLOSER AND 5108 03:57:24,964 --> 03:57:25,898 EXPLAIN WHAT EVERYBODY SAID TO 5109 03:57:25,965 --> 03:57:26,198 YOU. 5110 03:57:26,265 --> 03:57:29,335 I WON'T DO THAT. 5111 03:57:29,401 --> 03:57:37,576 WHAT YOU SAW WAS AN AMAZING TEAM 5112 03:57:37,643 --> 03:57:41,280 TO PROVIDE DATA AND IN A SECURE 5113 03:57:41,347 --> 03:57:42,982 AND GOVERNANCE ALIGNED FRAMEWORK 5114 03:57:43,048 --> 03:57:46,952 AND CLOLLABORATE DISCOVERY AND 5115 03:57:47,019 --> 03:57:49,955 IMPACT PATIENTS. 5116 03:57:50,022 --> 03:57:56,895 ONE WAY TO SIMPLIFY IT IS TO 5117 03:57:56,962 --> 03:57:58,063 REDUCE BARRIERS FOR DATA TO COME 5118 03:57:58,130 --> 03:57:58,330 OUT. 5119 03:57:58,397 --> 03:57:59,932 THAT'S WHAT WE SPENT THE 5120 03:57:59,999 --> 03:58:01,333 MAJORITY OF THE LAST SEVERAL 5121 03:58:01,400 --> 03:58:03,435 YEARS DOING AND IT'S A REQUIRED 5122 03:58:03,502 --> 03:58:04,737 FOUNDATIONAL INFRASTRUCTURE TO 5123 03:58:04,803 --> 03:58:07,306 DO THE KIND OF WORK PART OF 5124 03:58:07,373 --> 03:58:07,539 INCLUDE. 5125 03:58:07,606 --> 03:58:09,174 FOR ME THOUGH THE PART THAT'S 5126 03:58:09,241 --> 03:58:11,410 EXCITING ABOUT INCLUDE IS THAT 5127 03:58:11,477 --> 03:58:12,845 YOU'RE DOING SOMETHING THAT VERY 5128 03:58:12,911 --> 03:58:15,481 FEW, TO MY KNOWLEDGE, MAYBE NO 5129 03:58:15,547 --> 03:58:18,417 OTHER COORDINATING EFFORTS 5130 03:58:18,484 --> 03:58:20,219 AROUND A PARTICULAR CONDITION OR 5131 03:58:20,285 --> 03:58:24,790 DISEASE CONTEXT HAS EVER DONE. 5132 03:58:24,857 --> 03:58:26,358 EVEN TODAY YOU BRING TOGETHER 5133 03:58:26,425 --> 03:58:29,461 CLINICAL TRIALISTS, BASIC 5134 03:58:29,528 --> 03:58:30,496 SCIENTISTS, COHORT CREATION 5135 03:58:30,562 --> 03:58:34,033 EFFORTS IN WAYS THAT TRY TO 5136 03:58:34,099 --> 03:58:35,768 COMPLETE THIS ARC FROM 5137 03:58:35,834 --> 03:58:38,270 INDIVIDUAL STUDIES, INDIVIDUAL 5138 03:58:38,337 --> 03:58:39,672 PATIENTS AND PARTICIPANTS AND 5139 03:58:39,738 --> 03:58:41,607 BEGINS ALL THE WAY AT THE LEFT 5140 03:58:41,674 --> 03:58:43,709 AND THROUGH DEEP PHENOTYPING OR 5141 03:58:43,776 --> 03:58:44,910 CHARACTERIZATION DRIVE THE 5142 03:58:44,977 --> 03:58:46,512 FRAMEWORK INTO DATA THAT BECOMES 5143 03:58:46,578 --> 03:58:48,681 EMPOWERED AS INFORMATION AND WE 5144 03:58:48,747 --> 03:58:49,448 CAN DRIVE KNOWLEDGE CREATION AND 5145 03:58:49,515 --> 03:58:54,353 IMPACT. 5146 03:58:54,420 --> 03:58:56,789 THAT IS EXTREMELY HART TO DO IT 5147 03:58:56,855 --> 03:59:01,326 AT SCALE AND FAST. 5148 03:59:01,393 --> 03:59:03,062 UNIVERSALLY WHETHER YOU'RE A OR 5149 03:59:03,128 --> 03:59:04,296 PATIENT IN A HOSPITAL WITH DATE 5150 03:59:04,363 --> 03:59:08,300 OF DAVID, YOU'RE AT THE ANALOG 5151 03:59:08,367 --> 03:59:09,868 INDIVIDUAL LAYER AND USUALLY 5152 03:59:09,935 --> 03:59:14,573 THEY'RE THE MOST UNEM EMPOWERED 5153 03:59:14,640 --> 03:59:16,675 CONTEXT AND OUR JOB THROUGH THE 5154 03:59:16,742 --> 03:59:18,544 INFRASTRUCTURE IS TO DRIVE A 5155 03:59:18,610 --> 03:59:20,412 DIGITAL NON-LOCAL 5156 03:59:20,479 --> 03:59:21,814 COMMUNITY-BASED RESOURCE IN WAYS 5157 03:59:21,880 --> 03:59:24,216 THAT HARNESSES NEW TECHNOLOGIES 5158 03:59:24,283 --> 03:59:26,885 AND TOOLS IN WAYS YOU HAVEN'T 5159 03:59:26,952 --> 03:59:28,353 DONE BEFORE. 5160 03:59:28,420 --> 03:59:30,656 ULTIMATELY, THE WAY WE KNOW IT 5161 03:59:30,723 --> 03:59:33,058 SUCCEEDS IS IF THE IMPACT OF THE 5162 03:59:33,125 --> 03:59:33,892 INFRASTRUCTURE COMES BACK DOWN 5163 03:59:33,959 --> 03:59:35,027 TO THE INDIVIDUAL. 5164 03:59:35,094 --> 03:59:36,895 THAT'S SOMETHING NOT FORGET. 5165 03:59:36,962 --> 03:59:38,897 OUR GOAL IS TO TRANSLATE THE 5166 03:59:38,964 --> 03:59:41,333 INFRASTRUCTURE TO THE NEXT 5167 03:59:41,400 --> 03:59:41,967 PARTICIPANTS AND THEIR SPECIFIC 5168 03:59:42,034 --> 03:59:52,177 JOURNEY. 5169 03:59:53,078 --> 03:59:55,647 YOU FIND THE TRILOGY A FRAMEWORK 5170 03:59:55,714 --> 03:59:59,785 APPEARING. 5171 03:59:59,852 --> 04:00:02,888 WE ALL WHETHER YOU THINK MODEL 5172 04:00:02,955 --> 04:00:06,725 SYSTEMS OR CLINICAL TRIALS, OUR 5173 04:00:06,792 --> 04:00:07,893 FOCUS ON DEEPLY CHARACTERIZING 5174 04:00:07,960 --> 04:00:10,295 PARTICIPANTS, PATIENTS OR 5175 04:00:10,362 --> 04:00:12,164 SAMPLES, INTEGRATING THAT WITH A 5176 04:00:12,231 --> 04:00:14,700 SHARED FRAMEWORK OF MECHANISMS 5177 04:00:14,767 --> 04:00:16,401 OR OUTCOMES AS CONNECTED TO 5178 04:00:16,468 --> 04:00:19,671 TREATMENTS, INTERVENTION AND 5179 04:00:19,738 --> 04:00:20,139 RESPONSES. 5180 04:00:20,205 --> 04:00:22,374 THE REASON WE'RE DOING THAT IS 5181 04:00:22,441 --> 04:00:23,909 BECAUSE THE NUMBER OF SAESZ WE 5182 04:00:23,976 --> 04:00:25,844 HAVE CONTINUE TO GROW BUT THE 5183 04:00:25,911 --> 04:00:27,112 TECHNOLOGIES THAT CAN EMPOWER 5184 04:00:27,179 --> 04:00:29,615 HAVE ALSO GROWN AND THAT'S WHAT 5185 04:00:29,681 --> 04:00:31,316 YOU SEE THE TEAM HERE PLAYING 5186 04:00:31,383 --> 04:00:31,583 TOGETHER. 5187 04:00:31,650 --> 04:00:34,219 SO TO GET TO THAT SPACE OF 5188 04:00:34,286 --> 04:00:36,588 ACTUALLY BEING ABLE TO ASK THE 5189 04:00:36,655 --> 04:00:37,890 FOLLOWING QUESTION TO MY 5190 04:00:37,956 --> 04:00:38,891 KNOWLEDGE NOT EVERYBODY, ANY 5191 04:00:38,957 --> 04:00:41,860 HOSPITAL AND HOPEFULLY SOMEBODY 5192 04:00:41,927 --> 04:00:44,563 HERE CAN BE COUNTER FACTUAL CAN 5193 04:00:44,630 --> 04:00:46,265 ANSWER. 5194 04:00:46,331 --> 04:00:49,568 IF YOU HAVE A 46-YEAR-OLD 5195 04:00:49,635 --> 04:00:50,803 PARTICIPANT WITH DOWN SYNDROME 5196 04:00:50,869 --> 04:00:52,237 COMES TO YOUR HOSPITAL WITH A 5197 04:00:52,304 --> 04:00:54,807 COLLAPSED LUNG, WHO ARE THE 5198 04:00:54,873 --> 04:00:56,441 OTHER PARTICIPANTS OR PATIENTS 5199 04:00:56,508 --> 04:00:58,143 THAT HAVE BEEN LIKE THAT WITH 5200 04:00:58,210 --> 04:00:59,678 THE SAME CONDITION AND SAME 5201 04:00:59,745 --> 04:01:02,514 RESEARCH DATA OR CLINICAL DATA? 5202 04:01:02,581 --> 04:01:04,917 NOBODY CAN ANSWER THAT QUESTION 5203 04:01:04,983 --> 04:01:06,251 IN REAL TIME EITHER AS A 5204 04:01:06,318 --> 04:01:14,893 RESEARCHER OR AS A CLINICIAN. 5205 04:01:14,960 --> 04:01:19,965 57D CHALLENGE THE MODEL. 5206 04:01:20,032 --> 04:01:23,669 IN MANY WAYS AND THE INCLUDE 5207 04:01:23,735 --> 04:01:27,072 PROGRAM IS A TESTAMENT FOR THAT 5208 04:01:27,139 --> 04:01:28,974 PRECISION FRAMEWORK WRIT LARGE. 5209 04:01:29,041 --> 04:01:31,410 TO MY KNOWLEDGE NO ONE IS DOING 5210 04:01:31,476 --> 04:01:33,812 THE FRAMEWORK OF CO-CREATION 5211 04:01:33,879 --> 04:01:34,680 CLINICAL TRIALS, BASIC RESEARCH 5212 04:01:34,746 --> 04:01:38,917 AND UPCOMING COHORT PERSPECTIVE 5213 04:01:38,984 --> 04:01:41,486 STUDIES IN THIS COORDINATED 5214 04:01:41,553 --> 04:01:43,055 FRAMEWORK. 5215 04:01:43,121 --> 04:01:45,757 SO THIS IS A CHALLENGE. 5216 04:01:45,824 --> 04:01:49,161 YOU AND YOUR COMMUNITY ARE 5217 04:01:49,228 --> 04:01:51,029 SETTING THE STAGE WRIT LARGE CHA 5218 04:01:51,096 --> 04:01:52,998 WHAT IS POSSIBLE AROUND DATA 5219 04:01:53,065 --> 04:01:55,100 INTENSIVE RESEARCH IN WAYS THAT 5220 04:01:55,167 --> 04:01:57,970 COULD BE COORDINATED AND AS A 5221 04:01:58,036 --> 04:01:59,671 TEAM HIGHLIGHTED MULTIPLE TIMES 5222 04:01:59,738 --> 04:02:02,074 IT'S A RICH AREA OF 5223 04:02:02,140 --> 04:02:06,812 EXPERIMENTATION AND I'LL END 5224 04:02:06,879 --> 04:02:09,648 WITH THAT TRANSPARENCY BUT STILL 5225 04:02:09,715 --> 04:02:11,483 ONGOING EXPERIMENT AND THERE'S 5226 04:02:11,550 --> 04:02:12,818 NO PRECEDENT FOR DOING THAT. 5227 04:02:12,885 --> 04:02:14,319 WITH A LITTLE NEED YOUR FEEDBACK 5228 04:02:14,386 --> 04:02:17,589 AND CRITIQUE AND INPUT AND THE 5229 04:02:17,656 --> 04:02:20,025 ONLY WAY TO SUCCESS AND HAVE THE 5230 04:02:20,092 --> 04:02:21,026 POTENTIAL TO CHANGE OUR RESEARCH 5231 04:02:21,093 --> 04:02:23,595 WRIT LARGE AND BEING CONDUCTED 5232 04:02:23,662 --> 04:02:25,864 AND ONLY COMMUNITY-BASED 5233 04:02:25,931 --> 04:02:27,432 FRAMEWORKS CAN SUCCEED IN THAT 5234 04:02:27,499 --> 04:02:29,434 VISION AND WE HOPE INCLUDE CAN 5235 04:02:29,501 --> 04:02:31,103 DO THAT. 5236 04:02:31,169 --> 04:02:32,704 THANK YOU FOR YOUR ENGAGEMENT. 5237 04:02:32,771 --> 04:02:34,239 WE'LL BE AVAILABLE FOR 5238 04:02:34,306 --> 04:02:35,107 CONNECTING AND AGAIN CHALLENGE 5239 04:02:35,173 --> 04:02:36,808 US, INFORM US, ASK US QUESTIONS. 5240 04:02:36,875 --> 04:02:38,810 THIS IS GOING TO BE A SHARED 5241 04:02:38,877 --> 04:02:39,444 EXPERIMENT AS WE CONTINUE IN THE 5242 04:02:39,511 --> 04:02:39,811 TALK. 5243 04:02:39,878 --> 04:02:50,122 THANKS AGAIN. 5244 04:02:53,859 --> 04:02:55,127 >> THANK YOU TO THE WHOLE TEAM. 5245 04:02:55,193 --> 04:02:56,128 NOW WE HAVE ABOUT 15 MINUTES FOR 5246 04:02:56,194 --> 04:03:06,071 QUESTIONS. 5247 04:03:06,138 --> 04:03:09,908 >> I THINK THIS IS A FANTASTIC 5248 04:03:09,975 --> 04:03:11,343 TOOL AND OPPORTUNITY AND I WAS 5249 04:03:11,410 --> 04:03:14,680 THINKING ABOUT THE CONVERSATION 5250 04:03:14,746 --> 04:03:16,181 WE WERE HAVING IN THE BREAKOUT 5251 04:03:16,248 --> 04:03:22,154 GROUP ABOUT THE ACCESS OR 5252 04:03:22,220 --> 04:03:26,692 ACCESSIBILITY OF A.I. OF DATA 5253 04:03:26,758 --> 04:03:31,997 AND CURIOUS HOW YOU THINK ABOUT 5254 04:03:32,064 --> 04:03:33,098 INCORPORATING THOSE TECHNOLOGIES 5255 04:03:33,165 --> 04:03:36,835 INTO DIVING INTO THE DATA MORE 5256 04:03:36,902 --> 04:03:39,671 OR LESS BIAS THAN INDIVIDUAL 5257 04:03:39,738 --> 04:03:46,411 INVESTIGATORS MIGHT BE. 5258 04:03:46,478 --> 04:03:50,749 >> SO, YOUR POINT IS WELL TAKEN 5259 04:03:50,816 --> 04:03:53,618 AND WE'RE LEVERAGING NEW 5260 04:03:53,685 --> 04:03:54,319 TECHNOLOGIES WHETHER 5261 04:03:54,386 --> 04:03:56,722 INFRASTRUCTURE OR COMPUTATION. 5262 04:03:56,788 --> 04:03:58,256 A.I.'S A TRANSFORMATIVE 5263 04:03:58,323 --> 04:03:59,591 TECHNOLOGY THAT IS POISED TO 5264 04:03:59,658 --> 04:04:02,127 DISRUPT WHAT CAN BE DONE BOTH AT 5265 04:04:02,194 --> 04:04:04,997 THE INTAKE SIDE, HOW YOU GET 5266 04:04:05,063 --> 04:04:06,832 PROVISION AND ANALYZE AND 5267 04:04:06,898 --> 04:04:08,567 HARMONIZE AND THE ANALYTIC SIDE 5268 04:04:08,633 --> 04:04:10,102 AND AT LOWERING THE BARRIER FOR 5269 04:04:10,168 --> 04:04:11,670 PEOPLE WHO INTERACT WITH DATA 5270 04:04:11,737 --> 04:04:13,605 AND QUERY DATA. 5271 04:04:13,672 --> 04:04:17,509 SO WE ACTUALLY THINK OF THE 5272 04:04:17,576 --> 04:04:21,613 THREE LAYERS, POWER DATA, INGEST 5273 04:04:21,680 --> 04:04:24,182 AND CAPACITY TO BE INTEGRATED 5274 04:04:24,249 --> 04:04:29,588 AND HOW DO WE POWER FINDABILITY 5275 04:04:29,654 --> 04:04:32,691 AND CAN MERE MORTALS INTERACT 5276 04:04:32,758 --> 04:04:35,427 WITH DATA AND ASK QUESTIONS AND 5277 04:04:35,494 --> 04:04:38,363 CAN A.I. DRIVE NEW KNOWLEDGE IN 5278 04:04:38,430 --> 04:04:41,666 WAYS THAT'S DIFFICULT FOR HUMANS 5279 04:04:41,733 --> 04:04:42,501 AND IMAGINE MACHINE LEARNING 5280 04:04:42,567 --> 04:04:44,336 THAT DO FEATURE DETECTION AND 5281 04:04:44,403 --> 04:04:45,937 IMAGING AS A FRAMEWORK WHICH IS 5282 04:04:46,004 --> 04:04:47,372 A GREAT EXPERIMENT IN THE 5283 04:04:47,439 --> 04:04:57,716 CONTEMPT OF A.I. 5284 04:04:59,151 --> 04:05:01,853 >> HOW DO WE TAKE WHAT I CALL 5285 04:05:01,920 --> 04:05:05,123 GOOD OLD FASHIONED A.I. THE 5286 04:05:05,190 --> 04:05:05,690 ONTOLOGICAL CLASSIFICATIONS 5287 04:05:05,757 --> 04:05:07,292 WE'VE BEEN ABLE TO SHOW YOU AND 5288 04:05:07,359 --> 04:05:10,796 HOW WE'VE BEEN ABLE TO DIAGNOSIS 5289 04:05:10,862 --> 04:05:16,068 RARE DISEASES AND COMBINE THEM 5290 04:05:16,134 --> 04:05:20,872 WITH LARGER LANGUAGE MODELS AND 5291 04:05:20,939 --> 04:05:22,074 EVERYBODY'S WHETHER IT'S THE 5292 04:05:22,140 --> 04:05:23,308 BASTE RESEARCH DATA WE WERE 5293 04:05:23,375 --> 04:05:24,743 HEARING BEFORE AND THE PLEA, 5294 04:05:24,810 --> 04:05:27,045 HELP US MAKE OUR DATA MORE 5295 04:05:27,112 --> 04:05:31,883 FINDABLE AND INTEROPERABLE AND 5296 04:05:31,950 --> 04:05:34,553 HOW DO WE LOOK AT MORE THINGS OR 5297 04:05:34,619 --> 04:05:35,821 RELEVANT THINGS? 5298 04:05:35,887 --> 04:05:38,857 THE COMBINATION OF THE TWO 5299 04:05:38,924 --> 04:05:43,228 HOWEVER, IS INCREDIBLY POWERFUL. 5300 04:05:43,295 --> 04:05:50,902 PROBLEM WITH LARGE LANGUAGE 5301 04:05:50,969 --> 04:05:52,337 MODELS IT OUT OF THE BOX 5302 04:05:52,404 --> 04:05:53,738 PACKAGES IS BASED ON WHAT'S ON 5303 04:05:53,805 --> 04:05:54,005 THE WEB. 5304 04:05:54,072 --> 04:05:59,277 SO IT'S NOT LEARNING FROM OUR 5305 04:05:59,344 --> 04:06:00,545 OWN MOST APPRECIATION DATA BUT 5306 04:06:00,612 --> 04:06:03,014 AND OUR OWN STANDARDS IN WAYS WE 5307 04:06:03,081 --> 04:06:05,450 MODEL DATA AND THESE INCREDIBLE 5308 04:06:05,517 --> 04:06:09,855 TOOLS TOGETHER CAN MAKE THE 5309 04:06:09,921 --> 04:06:12,524 PROCESS OF HARMONIZING DATA 5310 04:06:12,591 --> 04:06:13,859 WHETHER IT'S A PATIENT DYING OF 5311 04:06:13,925 --> 04:06:16,528 A COLLAPSED LUNG OR NOT DYING OF 5312 04:06:16,595 --> 04:06:19,097 A COLLAPSED LUNG AS THE CASE MAY 5313 04:06:19,164 --> 04:06:23,535 BE, FORTUNATELY, WE'RE ABLE TO 5314 04:06:23,602 --> 04:06:26,471 USE THE COMBINATION TO SAY 5315 04:06:26,538 --> 04:06:29,941 HERE'S HOW WE REVEAL CANDIDATE 5316 04:06:30,008 --> 04:06:33,478 HYPOTHESES IN A LESS BIASSED 5317 04:06:33,545 --> 04:06:33,645 WAY. 5318 04:06:33,712 --> 04:06:38,984 IT'S A HUGE OPPORTUNITY AND 5319 04:06:39,050 --> 04:06:40,852 WE'RE COMBINING ALL THESE 5320 04:06:40,919 --> 04:06:41,119 TOGETHER. 5321 04:06:41,186 --> 04:06:43,688 >> A.I.'S NOT MAGIC AND THE KEY 5322 04:06:43,755 --> 04:06:44,990 PART IS FOR DATA TO BECOME A.I. 5323 04:06:45,056 --> 04:06:47,959 READY AS A FRAMEWORK. 5324 04:06:48,026 --> 04:06:50,495 SO WE CAN ASK THE QUESTION, HOW 5325 04:06:50,562 --> 04:06:53,064 MANY OTHER 46-YEAR-OLDS WITH 5326 04:06:53,131 --> 04:06:54,366 THIS PARTICULAR FEATURE SET HAVE 5327 04:06:54,432 --> 04:06:59,671 A COLLAPSED LIMB AND YOU DON'T 5328 04:06:59,738 --> 04:07:01,206 HAVE TO WRITE A SEQUEL CODE BUT 5329 04:07:01,273 --> 04:07:02,741 JUST ASK IT AND THAT'S WAYS TO 5330 04:07:02,807 --> 04:07:03,441 DO IT IN WAYS THAT ARE 5331 04:07:03,508 --> 04:07:06,711 TRANSFORMATIVE. 5332 04:07:06,778 --> 04:07:08,713 >> NYU SCHOOL OF MEDICINE. 5333 04:07:08,780 --> 04:07:11,283 I THINK THIS AS THE FIRST 5334 04:07:11,349 --> 04:07:12,284 EXAMPLE A HEALTH CARE DATA 5335 04:07:12,350 --> 04:07:12,984 ACROSS THE COUNTRY. 5336 04:07:13,051 --> 04:07:14,853 IS THERE A PLAN TO WORK WITH THE 5337 04:07:14,920 --> 04:07:17,556 U.K. CAN BIO BANK TO GET IT HERE 5338 04:07:17,622 --> 04:07:20,792 BECAUSE AT INDIVIDUAL LABS WE 5339 04:07:20,859 --> 04:07:23,662 ONLY DOWNLOAD SMALL PARTS AND 5340 04:07:23,728 --> 04:07:26,965 THIS COULD BE AN EFFORT WHERE 5341 04:07:27,032 --> 04:07:30,268 NIH CAN DOWNLOAD IT AND INSTEAD 5342 04:07:30,335 --> 04:07:33,772 OF PIECE MEALING IT AND TRYING 5343 04:07:33,838 --> 04:07:36,441 TO PUT IT TOGETHER. 5344 04:07:36,508 --> 04:07:38,710 >> I CAN APPROXIMATE AN ANSWER. 5345 04:07:38,777 --> 04:07:39,978 THE PRIMARY MANDATE IS FOR 5346 04:07:40,045 --> 04:07:50,388 INCLUDE FUNDED DATA. 5347 04:07:52,791 --> 04:07:56,962 HAVE A MANDATE TO COPY AND 5348 04:07:57,028 --> 04:08:02,100 PASTE OTHER COOL DATA SETS? 5349 04:08:02,167 --> 04:08:03,668 NO, BUT WE LOOK TO MAKE SURE 5350 04:08:03,735 --> 04:08:14,079 WE'RE INTEROPERABLE. 5351 04:08:26,591 --> 04:08:33,999 A 5352 04:08:34,065 --> 04:08:36,034 AND MAKING SURE THEY'RE 5353 04:08:36,101 --> 04:08:37,168 INTEROPERABLE WITH OTHER SETS. 5354 04:08:37,235 --> 04:08:38,903 >> THE SEAM IS VESTED IN THIS AN 5355 04:08:38,970 --> 04:08:43,308 MOST ARE MEMBERS OF G4, GH THE 5356 04:08:43,375 --> 04:08:48,480 COMMUNITY FOR DEVELOPING THE 5357 04:08:48,546 --> 04:08:56,988 STANDARDS AND SUPPORT DIFFERENT 5358 04:08:57,055 --> 04:08:59,658 DATA SETS AS MENTIONED FOR 5359 04:08:59,724 --> 04:09:02,994 CAVATICA AND ACROSS THE ATLANTIC 5360 04:09:03,061 --> 04:09:13,405 AND FURTHER BEYOND. 5361 04:09:16,274 --> 04:09:18,977 THERE'S POTENTIAL NEW BARRIERS 5362 04:09:19,044 --> 04:09:20,979 AND WHERE THEY CAN DRIVE CHANGE 5363 04:09:21,046 --> 04:09:22,113 IN THE LANDSCAPE. 5364 04:09:22,180 --> 04:09:22,814 >> THANK YOU. 5365 04:09:22,881 --> 04:09:25,250 I WANT TO ADD ONE THING. 5366 04:09:25,317 --> 04:09:29,087 WHILE WE'RE WAITING FOR THE 5367 04:09:29,154 --> 04:09:31,356 INTEROPERABILITY EFFORT YOU CAN 5368 04:09:31,423 --> 04:09:34,059 UPLOAD TO CAVATICA TO CO-ANALYZE 5369 04:09:34,125 --> 04:09:39,764 WITH INCLUDE DATA BUT NOT HUGE. 5370 04:09:39,831 --> 04:09:43,301 >> THE REAL SUCCESS FOR US IS 5371 04:09:43,368 --> 04:09:44,602 BEING YOU AS A COMMUNITY START 5372 04:09:44,669 --> 04:09:47,405 USING THE PLATFORM TO EMPOWER 5373 04:09:47,472 --> 04:09:51,109 YOUR DATA NOT JUST THE FIRST 5374 04:09:51,176 --> 04:09:54,946 DEPOSITION OF DATA BUT HAS VALUE 5375 04:09:55,013 --> 04:09:58,216 TO YOUR IMMEDIATE CONTEXT OF 5376 04:09:58,283 --> 04:10:00,085 ANALYSIS AND THAT'S WHAT WE'D 5377 04:10:00,151 --> 04:10:01,219 LOVE TO PARTNER WITH YOU ON. 5378 04:10:01,286 --> 04:10:03,488 >> THANK YOU FOR THE WORK YOU'VE 5379 04:10:03,555 --> 04:10:04,723 BEEN DOING FOR THE FIVE YEARS. 5380 04:10:04,789 --> 04:10:08,326 I DON'T ENVY ANY OF IT IN TRYING 5381 04:10:08,393 --> 04:10:11,329 TO HARMONIZE THE DATA SETS WE'RE 5382 04:10:11,396 --> 04:10:12,864 CONTRIBUTED OR GOING TO AND ARE 5383 04:10:12,931 --> 04:10:15,667 THERE STEPS FOR WHAT YOU'D USE 5384 04:10:15,734 --> 04:10:19,537 IN THE FUTURE EVEN FOR THE 5385 04:10:19,604 --> 04:10:21,406 VALUES FOR THE VARIABLE ARE THE 5386 04:10:21,473 --> 04:10:22,974 PLANS TO INCLUDE THE RACE 5387 04:10:23,041 --> 04:10:24,409 VARIABLES YOU SHOULD USE SO WHEN 5388 04:10:24,476 --> 04:10:26,978 WE'RE UPLOADING IT THERE'S LESS 5389 04:10:27,045 --> 04:10:29,347 EFFORTS AND STANDARDIZING THINGS 5390 04:10:29,414 --> 04:10:30,949 SO THERE'S LESS HARMONIZATION AT 5391 04:10:31,015 --> 04:10:31,349 THE END? 5392 04:10:31,416 --> 04:10:38,757 >> THANK YOU FOR THE QUESTION. 5393 04:10:38,823 --> 04:10:42,060 THE INCLUDE WORKING GROUPS 5394 04:10:42,127 --> 04:10:46,164 STANDARDIZATION IN 2019 AND 2020 5395 04:10:46,231 --> 04:10:51,002 HAVE A CORSET OF DATA ELEMENTS 5396 04:10:51,069 --> 04:10:53,271 WHICH WE PAID ATTENTION TO AND 5397 04:10:53,338 --> 04:10:57,008 NOW CALLED THE ELEMENTS OF 5398 04:10:57,075 --> 04:11:01,813 INTEREST IF ANYBODY'S DESIGNING 5399 04:11:01,880 --> 04:11:03,948 WANTS TO KNOW THE COMMON DATA 5400 04:11:04,015 --> 04:11:06,317 ELEMENTS ARE EASY TO SHARE. 5401 04:11:06,384 --> 04:11:11,356 HOWEVER, WE'RE NOT PRESCRIPTIVE. 5402 04:11:11,423 --> 04:11:21,966 WARE HERE TO TAKE THE DATA AND 5403 04:11:22,901 --> 04:11:29,841 WE HAVE A GREAT HUNT FOR MANY 5404 04:11:29,908 --> 04:11:33,044 SITES TO COLLECT DATA AND USING 5405 04:11:33,111 --> 04:11:35,380 THE STANDARD DICTIONARIES. 5406 04:11:35,447 --> 04:11:37,348 PERHAPS IT WILL GIVE ENOUGH 5407 04:11:37,415 --> 04:11:38,383 CRITICAL MASS TO BE MORE 5408 04:11:38,450 --> 04:11:39,784 PRESCRIPTIVE LIKE YOU WANT MONEY 5409 04:11:39,851 --> 04:11:41,653 THROUGH A MINI COHORT STUDY. 5410 04:11:41,719 --> 04:11:42,821 MAKE SURE YOU'RE COLLECTING THE 5411 04:11:42,887 --> 04:11:43,988 DATA THE SAME WAY AS THE 5412 04:11:44,055 --> 04:11:50,462 PROGRAM. 5413 04:11:50,528 --> 04:11:52,063 I THINK WE'RE MOVING FROM 5414 04:11:52,130 --> 04:11:53,131 FLEXIBLE AND LOOSE AND MOVING 5415 04:11:53,198 --> 04:11:54,899 TOWARDS THE RIGHT OF THAT 5416 04:11:54,966 --> 04:12:00,271 SPECTRUM SLOWLY BUT SURELY. 5417 04:12:00,338 --> 04:12:01,973 >> I'LL ADD THAT WE'RE WORK HARD 5418 04:12:02,040 --> 04:12:04,375 TO BUILD OUT THE BEST PRACTICE 5419 04:12:04,442 --> 04:12:06,244 MODEL WE'LL USE INTERNALLY FOR 5420 04:12:06,311 --> 04:12:09,481 THE INCLUDE DATA AND TALK ABOUT 5421 04:12:09,547 --> 04:12:09,814 HARMONIZATION. 5422 04:12:09,881 --> 04:12:12,083 WE CAN MAKE SURE IT'S MORE 5423 04:12:12,150 --> 04:12:12,317 VISIBLE. 5424 04:12:12,383 --> 04:12:17,889 IT'S DE FACTO WHAT WE'D 5425 04:12:17,956 --> 04:12:18,156 RECOMMEND. 5426 04:12:18,223 --> 04:12:22,327 I THINK WE'RE ALSO INVESTING THE 5427 04:12:22,393 --> 04:12:23,461 PROVIDENCE OF WHAT PEOPLE HAVE 5428 04:12:23,528 --> 04:12:25,730 BROUGHT IN AND WHAT'S IT LOOK 5429 04:12:25,797 --> 04:12:27,966 LIKE TO BE ABLE TO SHARE BACK 5430 04:12:28,032 --> 04:12:30,602 AND COULD BE A VALUABLE 5431 04:12:30,668 --> 04:12:32,704 CONTRIBUTOR IN THE CONSENSUS 5432 04:12:32,770 --> 04:12:34,806 BUILDING PROCESS. 5433 04:12:34,873 --> 04:12:38,810 THEY'RE CONSTANTLY CHANGES. 5434 04:12:38,877 --> 04:12:40,378 IT'S CONTINUED TO EVOLVE AND 5435 04:12:40,445 --> 04:12:41,079 IMPROVE HOPEFULLY. 5436 04:12:41,145 --> 04:12:44,015 I THINK THOSE ARE WAYS WE CAN 5437 04:12:44,082 --> 04:12:44,949 CONTRIBUTE BACK TO THE COMMUNITY 5438 04:12:45,016 --> 04:12:47,185 AND HELP MAKE BEST PRACTICES BUT 5439 04:12:47,252 --> 04:12:50,889 I AGREE WE'RE NOT TRYING TO BE 5440 04:12:50,955 --> 04:12:51,890 PRESCRIPTIVE AND SAY YOU MUST DO 5441 04:12:51,956 --> 04:12:53,157 IT THIS WAY. 5442 04:12:53,224 --> 04:12:57,061 >> WE'RE ALSO EXCITED ABOUT THE 5443 04:12:57,128 --> 04:12:59,297 UPCOMING COHORT EFFORTS THAT 5444 04:12:59,364 --> 04:13:01,599 WILL OPERATE UNDER A COMMON 5445 04:13:01,666 --> 04:13:03,401 PROTOCOL AND IF WE'RE DOING OUR 5446 04:13:03,468 --> 04:13:08,106 JOB WELL AND WE'LL SEE IF WE DO 5447 04:13:08,172 --> 04:13:11,676 THAT, ESSENTIALLY, COMMUNITIES 5448 04:13:11,743 --> 04:13:16,915 ADOPT FRAMEWORKS IF THEY'RE 5449 04:13:16,981 --> 04:13:17,749 VALUE DERIVED. 5450 04:13:17,815 --> 04:13:20,585 THE MINUTE I CHANGE IT I CAN 5451 04:13:20,652 --> 04:13:22,020 ANALYZE MY DATA IN CONTEXT. 5452 04:13:22,086 --> 04:13:24,789 ALL THE SUBJECTS INCLUDE. 5453 04:13:24,856 --> 04:13:28,026 YOU'RE RIGHT AT THE PRECIPICE OF 5454 04:13:28,092 --> 04:13:30,295 DEMONSTRATING THE ADOPTION VALUE 5455 04:13:30,361 --> 04:13:30,595 PROPOSITION. 5456 04:13:30,662 --> 04:13:32,697 THAT'S MOVING FORWARD. 5457 04:13:32,764 --> 04:13:36,801 >> IN THE INTEREST OF TIME WE 5458 04:13:36,868 --> 04:13:41,272 CAN ONLY HAVE ONE MORE QUESTION 5459 04:13:41,339 --> 04:13:43,241 BUT WE HAVE A TABLE AND IF YOU 5460 04:13:43,308 --> 04:13:46,911 HAVE ANY QUESTIONS YOU CAN WRITE 5461 04:13:46,978 --> 04:13:51,082 IT DOWN TO HELP ADDRESS IN THE 5462 04:13:51,149 --> 04:13:55,019 RESEMP AND APRIL 23 THEY'LL HOST 5463 04:13:55,086 --> 04:13:55,853 SO PLEASE JOIN US FOR THAT EVENT 5464 04:13:55,920 --> 04:14:03,428 AS WELL. 5465 04:14:03,494 --> 04:14:04,395 >> FROM THE UNIVERSITY OF 5466 04:14:04,462 --> 04:14:04,796 PITTSBURGH. 5467 04:14:04,862 --> 04:14:08,232 I'M A DATA SCIENTIST AND 5468 04:14:08,299 --> 04:14:09,534 EDUCATOR AND WE WANT TO INCREASE 5469 04:14:09,601 --> 04:14:15,573 THE NUMBER OF DATA SCIENTISTS 5470 04:14:15,640 --> 04:14:17,208 THROUGH EDUCATION AND LOOKING AT 5471 04:14:17,275 --> 04:14:19,043 THE PLATFORM WITH HARMONIZED 5472 04:14:19,110 --> 04:14:21,112 DATA AND WONDERFUL DATA SET, I 5473 04:14:21,179 --> 04:14:23,748 WAS WONDERING IF THERE'S AN 5474 04:14:23,815 --> 04:14:25,883 OPPORTUNITY FOR EDUCATORS TO USE 5475 04:14:25,950 --> 04:14:35,660 THIS PLATFORM FOR EDUCATIONAL 5476 04:14:35,727 --> 04:14:38,563 REASONS AND TRANSIT FROM JUPYTER 5477 04:14:38,630 --> 04:14:43,801 LAB AND HAVE IT PART OF 5478 04:14:43,868 --> 04:14:46,938 EDUCATION. 5479 04:14:47,005 --> 04:14:48,206 IS THERE ANYTHING BEING SET FOR 5480 04:14:48,272 --> 04:14:48,406 THAT? 5481 04:14:48,473 --> 04:14:55,647 >> WE HAVE DONE TRAININGS IN THE 5482 04:14:55,713 --> 04:15:03,121 PAST THIS IS THE VALUE OF A 5483 04:15:03,187 --> 04:15:07,659 COMMON PLATFORM WHICH OTHERS 5484 04:15:07,725 --> 04:15:13,097 USE. 5485 04:15:13,164 --> 04:15:16,501 AND AND MAY HAVE ACCESS TO A SET 5486 04:15:16,567 --> 04:15:19,671 OF OPEN LEARNING MATERIALS FOR 5487 04:15:19,737 --> 04:15:25,276 CAVATICA INCLUDED IN YOUR 5488 04:15:25,343 --> 04:15:35,486 PROGRAM 5489 04:16:09,253 --> 04:16:14,125 >> A BIGGER AMBITION WOULD BE 5490 04:16:14,192 --> 04:16:15,259 DATA SCIENCE TRAINING INNOVATION 5491 04:16:15,326 --> 04:16:17,261 GROWS IN THE CONTEXT OF INCLUDE. 5492 04:16:17,328 --> 04:16:21,799 CAN WE ESSENTIALLY EXPAND THE 5493 04:16:21,866 --> 04:16:23,067 POTENTIAL FOR HOW THE TRAINING 5494 04:16:23,134 --> 04:16:23,735 CAN OCCUR THROUGH THE DATA SETS 5495 04:16:23,801 --> 04:16:31,909 AND RESOURCES. 5496 04:16:31,976 --> 04:16:35,313 AND FOR US IT WILL BE REAL 5497 04:16:35,379 --> 04:16:36,147 EXCITING TO INNOVATE WHAT IS 5498 04:16:36,214 --> 04:16:38,449 POTENTIAL FOR TRAINING IF YOU 5499 04:16:38,516 --> 04:16:41,018 HAVE ACCESS TO THESE RESOURCES, 5500 04:16:41,085 --> 04:16:42,687 MULTI-MODAL DATA AND CLOUD 5501 04:16:42,754 --> 04:16:43,855 RESOURCE AND COMPUTE 5502 04:16:43,921 --> 04:16:46,958 ENVIRONMENTS, PROJECT SPACES. 5503 04:16:47,024 --> 04:16:50,094 I THINK THAT'S AN UNTESTED ARENA 5504 04:16:50,161 --> 04:16:51,996 IN THE CONTEXT OF TRAINING AND 5505 04:16:52,063 --> 04:16:53,998 I'M SURE YOU'LL SEE IT AND WE 5506 04:16:54,065 --> 04:16:55,233 SEE IT WRIT LARGE. 5507 04:16:55,299 --> 04:16:58,069 DATA SCIENCE IS THE MOST 5508 04:16:58,136 --> 04:16:59,203 LIMITING FACTOR IN MOST RESEARCH 5509 04:16:59,270 --> 04:17:01,939 ENVIRONMENTS I'M SURE FOR ALL OF 5510 04:17:02,006 --> 04:17:02,106 YOU. 5511 04:17:02,173 --> 04:17:03,775 IT'S A REAL BARRIER. 5512 04:17:03,841 --> 04:17:07,678 PLEASE FOLLOW-UP AND LET'S TALK 5513 04:17:07,745 --> 04:17:09,313 ABOUT THIS. 5514 04:17:09,380 --> 04:17:12,416 >> THANKS FOR THE GREAT SESSION 5515 04:17:12,483 --> 04:17:12,617 AGAIN. 5516 04:17:12,683 --> 04:17:22,927 THANK YOU. 5517 04:17:22,994 --> 04:17:33,004 >> 5518 04:18:08,840 --> 04:18:09,173 >> GOOD AFTERNOON. 5519 04:18:09,240 --> 04:18:13,144 THIS IS OUR LAST SESSION BEFORE 5520 04:18:13,211 --> 04:18:20,418 THE POSTER BUT WE'LL ENERGIZE 5521 04:18:20,484 --> 04:18:21,986 YOU TO TALK TO THE TRAINING 5522 04:18:22,053 --> 04:18:25,223 SESSIONS AND WE HAVE 68 POSTERS. 5523 04:18:25,289 --> 04:18:27,158 IT'S MY GREAT HONOR TO PRESENT 5524 04:18:27,225 --> 04:18:30,061 ON THE TOPIC OF EARLY CAREER 5525 04:18:30,127 --> 04:18:31,362 OPPORTUNITIES AND WE HAVE TWO 5526 04:18:31,429 --> 04:18:32,897 FANTASTIC SPEAKERS OR THE LAST 5527 04:18:32,964 --> 04:18:36,334 SESSION. 5528 04:18:36,400 --> 04:18:40,872 THE FIRST SPEAKER IS THE CURRENT 5529 04:18:40,938 --> 04:18:42,874 CHAIR OF DEPARTMENT OF 5530 04:18:42,940 --> 04:18:43,875 KINESIOLOGY AND HEALTH AT 5531 04:18:43,941 --> 04:18:45,443 GEORGIA STATE UNIVERSITY. 5532 04:18:45,509 --> 04:18:49,580 AND IN HIS SHORT 16 YEARS OF 5533 04:18:49,647 --> 04:18:52,450 CAREER AT GSU HE HAS TRAINED 5534 04:18:52,516 --> 04:18:54,952 MANY STUDENTS AND TRAINEES. 5535 04:18:55,019 --> 04:18:57,688 HE HAS ALSO RECEIVED AWARDS FOR 5536 04:18:57,755 --> 04:19:03,928 HIS MENTORSHIP INCLUDING THE NIH 5537 04:19:03,995 --> 04:19:08,065 OFFICE SUPPLEMENT FOR MENTORING. 5538 04:19:08,132 --> 04:19:11,602 AND I'M POSITIVE YOU'LL LEARN 5539 04:19:11,669 --> 04:19:15,907 FROM HIS IMPACTFUL MENTORSHIP. 5540 04:19:15,973 --> 04:19:18,142 THE SECOND IS RESEARCH ASSISTANT 5541 04:19:18,209 --> 04:19:19,977 PROFESSOR AT UNC SCHOOL OF 5542 04:19:20,044 --> 04:19:21,445 MEDICINE AND THROUGH INCLUDE 5543 04:19:21,512 --> 04:19:23,581 FUNDED PROJECTS WE WILL LEARN 5544 04:19:23,648 --> 04:19:26,651 WHAT SHE IS DOING TO UNBLOCK 5545 04:19:26,717 --> 04:19:28,219 SOME MYSTERIES OF CEREBRAL 5546 04:19:28,286 --> 04:19:30,087 SPINAL FLUID DYNAMICS AND 5547 04:19:30,154 --> 04:19:31,389 ASSOCIATED NEURAL AND CLINICAL 5548 04:19:31,455 --> 04:19:34,358 OUTCOMES IN INFANTS WITH DOWN 5549 04:19:34,425 --> 04:19:34,692 SYNDROME. 5550 04:19:34,759 --> 04:19:37,929 BACK IN FALL OF 2022, SHE 5551 04:19:37,995 --> 04:19:39,664 RECEIVED A FIVE-YEAR NICHD 5552 04:19:39,730 --> 04:19:42,900 CAREER DEVELOPMENT AWARD AND WE 5553 04:19:42,967 --> 04:19:46,304 WILL HEAR FROM HER AS WELL. 5554 04:19:46,370 --> 04:19:56,881 SO THANK YOU TO BOTH SPEAKERS. 5555 04:20:24,542 --> 04:20:26,944 I'M HONORED TO SHARE WITH YOU 5556 04:20:27,011 --> 04:20:29,413 MY EXPERIENCE IN MENTORING AND 5557 04:20:29,480 --> 04:20:31,682 PROVIDING THE YOUNG RESEARCHERS 5558 04:20:31,749 --> 04:20:33,184 OPPORTUNITIES AND IDEAS ABOUT 5559 04:20:33,250 --> 04:20:39,657 MENTORING. 5560 04:20:39,724 --> 04:20:42,026 MY BACKGROUND IS I WAS BORN AND 5561 04:20:42,093 --> 04:20:45,196 RAISED IN CHINA AND WENT TO 5562 04:20:45,262 --> 04:20:52,003 COLLEGE AND THEN RECEIVED MY 5563 04:20:52,069 --> 04:20:54,939 MA 5564 04:20:55,006 --> 04:21:05,483 MASTER'S DEGREE IN SHANGHAI. 5565 04:21:27,271 --> 04:21:31,409 AND I'VE ENJOYED THE DYNAMIC IN 5566 04:21:31,475 --> 04:21:32,009 THE COMMUNITY AND SUPPORTIVE 5567 04:21:32,076 --> 04:21:37,381 DOWN SYNDROME COMMUNITY. 5568 04:21:37,448 --> 04:21:41,786 AND IN SPRING OF 2021 I RECEIVED 5569 04:21:41,852 --> 04:21:47,525 AN EMAIL FROM CHAIR OF THE 5570 04:21:47,591 --> 04:21:51,762 AWARDS COMMITTEE AND I NEVER 5571 04:21:51,829 --> 04:21:53,431 THOUGHT I'D RECEIVE STUDENT 5572 04:21:53,497 --> 04:21:54,632 MENTORING AWARD BECAUSE I FEEL 5573 04:21:54,698 --> 04:21:57,301 LIKE I WAS TOO YOUNG. 5574 04:21:57,368 --> 04:22:04,442 AND THE AWARD IS FOR MORE 5575 04:22:04,508 --> 04:22:05,976 ESTABLISHED RESEARCHER. 5576 04:22:06,043 --> 04:22:10,948 THAT AWARD WAS ESTABLISHED IN 5577 04:22:11,015 --> 04:22:11,215 2020. 5578 04:22:11,282 --> 04:22:18,255 IN 2021 I WAS A SECOND RECIPIENT 5579 04:22:18,322 --> 04:22:20,791 CAN'T COMPARE MYSELF TO THE 5580 04:22:20,858 --> 04:22:23,160 SECOND RECIPIENT AND I FEEL LIKE 5581 04:22:23,227 --> 04:22:27,231 THAT MUST NOT BE TRUE UNTIL MY 5582 04:22:27,298 --> 04:22:29,166 WONDERFUL STUDENTS AND 5583 04:22:29,233 --> 04:22:30,267 CONGRATULATED ME FOR RECEIVING 5584 04:22:30,334 --> 04:22:30,868 THAT AWARD. 5585 04:22:30,935 --> 04:22:35,539 I WAS AMAZED AND THRILLED AND 5586 04:22:35,606 --> 04:22:36,707 HUMBLED AND THEN REALIZED I NEED 5587 04:22:36,774 --> 04:22:41,979 TO LOCK -- LOOK AT THE AWARD 5588 04:22:42,046 --> 04:22:43,681 AND READ THE CRITERIA. 5589 04:22:43,747 --> 04:22:45,950 I WANT TO READ THOSE TO YOU AND 5590 04:22:46,016 --> 04:22:49,887 IT RECOGNIZES THE LONG-TERM 5591 04:22:49,954 --> 04:22:53,891 IMPACT OF MENTORING THE CAREERS 5592 04:22:53,958 --> 04:22:54,625 OF SCIENTISTS. 5593 04:22:54,692 --> 04:22:56,994 SPECIFICALLY LOOKING AT THE 5594 04:22:57,061 --> 04:22:59,430 CONTRIBUTION TO WOMEN IN SCIENCE 5595 04:22:59,497 --> 04:23:01,332 ENGINEERING, UNDERGRAD STUDENT 5596 04:23:01,398 --> 04:23:02,867 EXPERIENCE AND ENGINEERING AND 5597 04:23:02,933 --> 04:23:03,134 OUTREACH. 5598 04:23:03,200 --> 04:23:08,939 I FEEL LIKE I DID ALL OF THOSE 5599 04:23:09,006 --> 04:23:10,975 BUT NOT TO THE LEVEL OF 5600 04:23:11,041 --> 04:23:12,076 RECEIVING THE AWARD. 5601 04:23:12,143 --> 04:23:14,245 ANYWAY BY LOOKING AT WHAT I HAVE 5602 04:23:14,311 --> 04:23:16,213 DONE IN TERMS OF RESEARCH AND 5603 04:23:16,280 --> 04:23:20,050 HOW I USED MY RESEARCH AS A 5604 04:23:20,117 --> 04:23:21,218 BRIDGE TO MENTOR STUDENTS AND DO 5605 04:23:21,285 --> 04:23:23,454 OUTREACH. 5606 04:23:23,521 --> 04:23:25,222 I AM ENGINEERING BACKGROUND AND 5607 04:23:25,289 --> 04:23:27,024 HAVE AN ENGINEERING BACKGROUND 5608 04:23:27,091 --> 04:23:30,161 AND DO BASIC RESEARCH AND 5609 04:23:30,227 --> 04:23:32,997 LOOKING AT NEURAL MOTOR 5610 04:23:33,063 --> 04:23:34,298 DEVELOPMENT IN CHILDREN WITH 5611 04:23:34,365 --> 04:23:35,666 DOWN SYNDROME AND INTERESTED IN 5612 04:23:35,733 --> 04:23:39,203 INVESTIGATING THE EFFECTIVENESS 5613 04:23:39,270 --> 04:23:42,273 OF PEDIATRIC INTERVENTION AND 5614 04:23:42,339 --> 04:23:44,341 FOCUSSED ON THE INFANT 5615 04:23:44,408 --> 04:23:47,244 INTERVENTION BY USING DIFFERENT 5616 04:23:47,311 --> 04:23:49,180 PARADIGMS. 5617 04:23:49,246 --> 04:23:50,748 FOR EXAMPLE, IN TRAINING AND I 5618 04:23:50,814 --> 04:23:53,184 FEEL LIKE THESE ARE THE THINGS I 5619 04:23:53,250 --> 04:23:59,657 HAVE DONE BUT I DON'T KNOW THAT 5620 04:23:59,723 --> 04:24:03,827 WHY THAT LED ME TO THE MENTORING 5621 04:24:03,894 --> 04:24:04,128 EXPERIENCE. 5622 04:24:04,195 --> 04:24:05,596 I'M LOOKING AT WHAT I'VE DONE 5623 04:24:05,663 --> 04:24:07,531 OVER THE YEARS AND CERTAINLY I 5624 04:24:07,598 --> 04:24:08,399 HAVE BEEN DEALING WITH 5625 04:24:08,465 --> 04:24:12,369 DIVERSITY, EQUITY, INCLUSION AND 5626 04:24:12,436 --> 04:24:15,206 ACCESSIBILITY IN RESEARCH 5627 04:24:15,272 --> 04:24:15,839 CONDUC 5628 04:24:15,906 --> 04:24:16,473 CONDUCTION, STUDENT MENTORING 5629 04:24:16,540 --> 04:24:17,074 AND BEYOND. 5630 04:24:17,141 --> 04:24:19,677 IN TERMS OF STUDENT MENTORING 5631 04:24:19,743 --> 04:24:24,748 AND I WAS FORTUNATE TO HAVE 5632 04:24:24,815 --> 04:24:26,717 WORKED WITH DIVERSE STUDENTS AND 5633 04:24:26,784 --> 04:24:28,852 I'M WORKING AT GEORGIA STATE 5634 04:24:28,919 --> 04:24:30,454 UNIVERSITY IN DOWNTOWN ATLANTA. 5635 04:24:30,521 --> 04:24:31,889 IF YOU DO NOT KNOW ATLANTA, I 5636 04:24:31,956 --> 04:24:37,528 CAN TELL YOU IT'S PROBABLY THE 5637 04:24:37,595 --> 04:24:41,098 MOST DIVERSE CITY POPULATION. 5638 04:24:41,165 --> 04:24:43,133 AT GEORGIA STATE WE HAVE MORE 5639 04:24:43,200 --> 04:24:45,202 THAN HALF STUDENTS COMING FROM 5640 04:24:45,269 --> 04:24:47,805 AFRICAN AMERICAN BACKGROUND. 5641 04:24:47,871 --> 04:24:53,477 WE HAVE ASIAN, CAUCASIAN AND 5642 04:24:53,544 --> 04:24:55,879 ALSO HISPANIC POPULATION. 5643 04:24:55,946 --> 04:24:57,214 WE HAVE EXCELLENT POPULATION OF 5644 04:24:57,281 --> 04:25:00,618 STUDENT BODY I WORK WITH AND 5645 04:25:00,684 --> 04:25:03,988 ALSO FOR MY OWN GROUP AND I HAVE 5646 04:25:04,054 --> 04:25:07,558 MENTORED STUDENTS FROM DIFFERENT 5647 04:25:07,625 --> 04:25:10,828 BACKGROUNDS FROM PHYSICAL 5648 04:25:10,894 --> 04:25:12,830 THERAPY, MEDICINE, ENGINEERING 5649 04:25:12,896 --> 04:25:15,232 ALL KINDS OF YAB BACKGROUND THAT 5650 04:25:15,299 --> 04:25:16,800 COME TO ME AND WE CAME TOGETHER 5651 04:25:16,867 --> 04:25:19,670 AND FORMED A TEAM AND ONE HALF 5652 04:25:19,737 --> 04:25:23,040 OF MY STUDENTS ARE WOMEN 5653 04:25:23,107 --> 04:25:24,074 SCIENTISTS OR CLINICIANS AND 5654 04:25:24,141 --> 04:25:27,244 GRATEFUL FOR THEIR TRUST IN ME 5655 04:25:27,311 --> 04:25:29,313 AND FOR THE WONDERFUL 5656 04:25:29,380 --> 04:25:31,448 RELATIONSHIP IN WORKING 5657 04:25:31,515 --> 04:25:31,715 TOGETHER. 5658 04:25:31,782 --> 04:25:34,285 SO I'M GOING SHARE WITH YOU SOME 5659 04:25:34,351 --> 04:25:36,854 OF THE EXPERIENCE I HAD WITH THE 5660 04:25:36,920 --> 04:25:39,290 STUDENTS AND CERTAINLY IT'S NOT 5661 04:25:39,356 --> 04:25:40,591 INCLUSIVE AND A WANT TO INITIATE 5662 04:25:40,658 --> 04:25:45,095 THE CONVERSATION AND SEE WHAT WE 5663 04:25:45,162 --> 04:25:47,665 CAN DO TO BRING PEOPLE FROM 5664 04:25:47,731 --> 04:25:53,103 DIFFERENT BACKGROUNDS AND WORK 5665 04:25:53,170 --> 04:25:55,072 TOGETHER AND ADVANCE SCIENCE. 5666 04:25:55,139 --> 04:25:57,508 I WORK WITH EACH STUDENT AND 5667 04:25:57,574 --> 04:26:00,511 LOOK AT THE WEAKNESS AND TRYING 5668 04:26:00,577 --> 04:26:02,446 TO SITE THEM TO DIFFERENT 5669 04:26:02,513 --> 04:26:02,880 PROJECTS. 5670 04:26:02,946 --> 04:26:04,848 EACH STUDENT WILL LEAD ONE 5671 04:26:04,915 --> 04:26:07,418 PROJECT AND WE'LL BE PART OF THE 5672 04:26:07,484 --> 04:26:09,119 MEMBER OF THE OTHER PUBLIC 5673 04:26:09,186 --> 04:26:14,825 HEALTH IN TRYING TO CREATE 5674 04:26:14,892 --> 04:26:16,260 COHESIVE TEAM AND TO BENEFIT 5675 04:26:16,327 --> 04:26:17,628 THEIR OWN GROWTH AND LEARN TEAM 5676 04:26:17,695 --> 04:26:23,967 SCIENCE. 5677 04:26:24,034 --> 04:26:26,503 AND WE NEED TO LEARN HOW TO DO 5678 04:26:26,570 --> 04:26:28,372 TEAM RESEARCH AND SCIENCE AND 5679 04:26:28,439 --> 04:26:30,240 GIVE THEM ENOUGH EXPOSURE TO 5680 04:26:30,307 --> 04:26:31,642 CONNECT TO POPULATIONS. 5681 04:26:31,709 --> 04:26:37,181 DOWN SYNDROME IS ONE I STUDIED 5682 04:26:37,247 --> 04:26:41,318 AND I ALSO STUDIED SYNDROMES AND 5683 04:26:41,385 --> 04:26:44,621 GENESIS AND CLINICAL POPULATIONS 5684 04:26:44,688 --> 04:26:48,158 AND IT'S ONE OF MY FAVORITE. 5685 04:26:48,225 --> 04:26:50,094 SO INCLUDES QUESTIONS IN MY 5686 04:26:50,160 --> 04:26:51,295 RESEARCH TEAM. 5687 04:26:51,362 --> 04:26:55,699 I THINK THAT'S REALLY IMPORTANT 5688 04:26:55,766 --> 04:26:58,502 BECAUSE YOU GIVE STUDENTS A 5689 04:26:58,569 --> 04:27:00,504 CHANCE TO MENTOR AND TRY TO 5690 04:27:00,571 --> 04:27:01,372 LEARN MENTORING SKILLS AND TRY 5691 04:27:01,438 --> 04:27:04,041 TO LEARN FROM EACH OTHER THERE'S 5692 04:27:04,108 --> 04:27:05,909 A LOT WE CAN LEARN FROM EACH 5693 04:27:05,976 --> 04:27:06,744 OTHER. 5694 04:27:06,810 --> 04:27:09,079 SO I REALLY THINK THAT WHAT 5695 04:27:09,146 --> 04:27:11,148 WORKS FOR ME IS I HAVE GROUP 5696 04:27:11,215 --> 04:27:15,886 MEETINGS AND INDIVIDUAL MEETINGS 5697 04:27:15,953 --> 04:27:18,422 AND FROM MY PERSPECTIVE AND I 5698 04:27:18,489 --> 04:27:19,390 FEEL FROM THE INDIVIDUAL 5699 04:27:19,456 --> 04:27:23,694 MEETINGS I REALLY GET TO KNOW 5700 04:27:23,761 --> 04:27:25,829 EACH OF MY STUDENTS AND 5701 04:27:25,896 --> 04:27:27,297 UNDERSTAND WHERE THEY STRUGGLE 5702 04:27:27,364 --> 04:27:35,806 AND WHAT THEY'RE PROUD OF AND 5703 04:27:35,873 --> 04:27:42,312 YOU HAVE TO BE PATIENT AND MAKE 5704 04:27:42,379 --> 04:27:45,616 AND THEY FOUND A SOLUTION TO 5705 04:27:45,682 --> 04:27:48,118 SOLVE PROBLEMS AND SO IT'S 5706 04:27:48,185 --> 04:27:51,321 NOBODY'S FAULT BUT WE NEED TO 5707 04:27:51,388 --> 04:27:53,257 UNDERSTAND EACH OTHER AND KNOW 5708 04:27:53,323 --> 04:27:56,093 WHAT WE NEED TO FOCUS ON AND SET 5709 04:27:56,160 --> 04:27:56,960 A REASONABLE TIME LINE AND 5710 04:27:57,027 --> 04:28:03,200 THAT'S REALLY IMPORTANT. 5711 04:28:03,267 --> 04:28:07,337 AND ONE MIFF STUDENTS TOOK 5712 04:28:07,404 --> 04:28:08,772 MATERNAL LEAVE AND THAT WAS NOT 5713 04:28:08,839 --> 04:28:10,808 THE PLAN BUT IT HAPPENED AND WE 5714 04:28:10,874 --> 04:28:12,810 HAVE TO HAVE TIME FOR HER TO 5715 04:28:12,876 --> 04:28:15,179 TAKE CARE OF HER FAMILY AND THEN 5716 04:28:15,245 --> 04:28:21,185 GET BACK TO RESEARCH AND THAT'S 5717 04:28:21,251 --> 04:28:23,754 SOME THINGS WE NEED TO 5718 04:28:23,821 --> 04:28:24,588 UNDERSTAND AND PROVIDE A 5719 04:28:24,655 --> 04:28:29,827 SOLUTION AND REPORT AND IT COMES 5720 04:28:29,893 --> 04:28:37,067 FROM OTHER'S TRUST AND LEARN 5721 04:28:37,134 --> 04:28:42,372 WHERE YOU STRUGGLE AND HOW YOU 5722 04:28:42,439 --> 04:28:51,315 CAN SUPPORT AND I THINK WHEN 5723 04:28:51,381 --> 04:28:53,383 THEY CAME TO MY LAB IT DIDN'T 5724 04:28:53,450 --> 04:28:55,419 FEEL LIKE MUCH AT ALL AND 5725 04:28:55,486 --> 04:28:58,655 THERE'S TIME TO WORK TOGETHER, 5726 04:28:58,722 --> 04:29:00,224 FOUR, FIVE YEARS AHEAD IF WE 5727 04:29:00,290 --> 04:29:03,093 HAVE A GOOD PLAN BY THEN OF THE 5728 04:29:03,160 --> 04:29:04,194 DOCTORAL STUDY AND YOU SHOULD BE 5729 04:29:04,261 --> 04:29:07,664 PROUD OF YOURSELVES BECAUSE 5730 04:29:07,731 --> 04:29:09,199 YOU'RE EQUIPPED WITH MOVING TO 5731 04:29:09,266 --> 04:29:10,200 THE NEXT LEVEL. 5732 04:29:10,267 --> 04:29:13,203 AND I'M PROUD TO SAY THAT MOST 5733 04:29:13,270 --> 04:29:16,473 OF MY DOCTORAL STUDENTS LANDED 5734 04:29:16,540 --> 04:29:19,009 THEIR FIRST GROP UPON GARAGE 5735 04:29:19,076 --> 04:29:20,410 WEIGHING AND ARE PROUD OF 5736 04:29:20,477 --> 04:29:21,144 THEMSELVES AND MYSELF. 5737 04:29:21,211 --> 04:29:25,115 AND THE OTHER THING I DID I 5738 04:29:25,182 --> 04:29:26,683 THINK AS A RESEARCHER WE ALL 5739 04:29:26,750 --> 04:29:30,721 FOCUSSED ON RESEARCH BUT AT THE 5740 04:29:30,787 --> 04:29:32,089 UNIVERSITY WE ALSO HAVE 5741 04:29:32,155 --> 04:29:33,357 INSTRUCTORS TO RESIDENTS AND 5742 04:29:33,423 --> 04:29:36,059 NEED TO TAKE CARE OF THE 5743 04:29:36,126 --> 04:29:42,966 UNDERGRAD, GRADUATE STUDENTS. 5744 04:29:43,033 --> 04:29:46,737 REMEMBER YOU CAN BRING 5745 04:29:46,803 --> 04:29:48,372 INTERESTING TO THE UNDERGRAD 5746 04:29:48,438 --> 04:29:51,742 CLASSES AND BEING PATIENT WITH 5747 04:29:51,808 --> 04:29:53,577 STUDENTS AND UNDERSTAND SOME 5748 04:29:53,644 --> 04:29:55,245 COME FROM UNDER REPRESENTED 5749 04:29:55,312 --> 04:30:00,817 BACKGROUNDS AND DON'T HAVE GOOD 5750 04:30:00,884 --> 04:30:02,386 MATH SKILLS OR VERY GOOD SKILLS 5751 04:30:02,452 --> 04:30:04,855 AND TO SURVIVE CLASSES YOU NEED 5752 04:30:04,922 --> 04:30:10,060 TO DEVELOP STEPS AND PROCEDURES 5753 04:30:10,127 --> 04:30:16,733 TO HELP THEM AND INTRODUCE 5754 04:30:16,800 --> 04:30:17,434 RESEARCH OPPORTUNITIES AND THEY 5755 04:30:17,501 --> 04:30:22,873 FEEL LUKE IT'S OUT OF REACH FOR 5756 04:30:22,940 --> 04:30:26,810 THEM BUT IF YOU LEARN MORE THEY 5757 04:30:26,877 --> 04:30:29,379 CAN DO SOMETHING FOR YOU AND BE 5758 04:30:29,446 --> 04:30:29,947 PROUD OF THE TEAM. 5759 04:30:30,013 --> 04:30:33,417 AT OUR UNIVERSITY AND WE HAVE 5760 04:30:33,483 --> 04:30:36,119 PROGRAMS AND WE HAVE IN MY 5761 04:30:36,186 --> 04:30:38,255 DEPARTMENT WE HAVE RESEARCH 5762 04:30:38,322 --> 04:30:45,028 INTERNSHIP AND WE HAVE UNDERGRAD 5763 04:30:45,095 --> 04:30:45,896 SUMMER SCHOLAR PROGRAM. 5764 04:30:45,963 --> 04:30:49,633 THEY CAN APPLY FOR THE PROGRAM 5765 04:30:49,700 --> 04:30:54,905 AND GET WHOLE SUMMER WORKING 5766 04:30:54,972 --> 04:30:58,275 WITH RESEARCHERS AND UNDERSTAND 5767 04:30:58,342 --> 04:31:01,678 DEVELOP RESEARCH SKILLS AND LOOK 5768 04:31:01,745 --> 04:31:03,380 AT OPPORTUNITIES AND LET ME GIVE 5769 04:31:03,447 --> 04:31:04,948 AN EXAMPLE AT THE AMERICAN 5770 04:31:05,015 --> 04:31:06,617 SOCIETY OF BIO MECHANIC. 5771 04:31:06,683 --> 04:31:09,920 A UNIQUE PROGRAM WAS ESTABLISHED 5772 04:31:09,987 --> 04:31:12,289 CALLED BE SURE TO STIPULATE THE 5773 04:31:12,356 --> 04:31:13,357 INTEREST FROM UNDERGRAD STUDENTS 5774 04:31:13,423 --> 04:31:16,393 TO DO RESEARCH AND AGAIN THEY 5775 04:31:16,460 --> 04:31:18,862 GET FINANCIAL SUPPORT TO WORK 5776 04:31:18,929 --> 04:31:20,864 WITH OUTSTANDING RESEARCHERS IN 5777 04:31:20,931 --> 04:31:25,569 THE FIELD FOR A WHOLE SUMMER AND 5778 04:31:25,636 --> 04:31:28,572 YOU CAN LEARN IF THAT IS THEIR 5779 04:31:28,639 --> 04:31:31,608 PASSION FOR THE RESEARCH, I 5780 04:31:31,675 --> 04:31:34,144 THINK THEY'RE WONDERFUL 5781 04:31:34,211 --> 04:31:34,478 OPPORTUNITIES. 5782 04:31:34,544 --> 04:31:38,115 AS A RESEARCHER WE FOCUS ON WHAT 5783 04:31:38,181 --> 04:31:39,683 WE DO AS A RESEARCH BUT I THINK 5784 04:31:39,750 --> 04:31:40,651 THERE'S SOMETHING BEYOND THAT 5785 04:31:40,717 --> 04:31:48,492 AND WE CAN REALLY LOOK AT THE 5786 04:31:48,558 --> 04:31:49,226 PIPELINE TO GET YOUNGER 5787 04:31:49,292 --> 04:31:51,695 UNDERGRAD STUDENTS IN THE 5788 04:31:51,762 --> 04:31:53,930 PIPELINE AND TRADE THEM AND TO 5789 04:31:53,997 --> 04:31:55,699 PREPARE THEM FOR THE NEXT 5790 04:31:55,766 --> 04:31:59,002 GENERATION OF RESEARCHERS. 5791 04:31:59,069 --> 04:32:02,572 ONE IDEA FOR THE NATIONAL 5792 04:32:02,639 --> 04:32:04,307 OUTREACH IS I ESTABLISHED A 5793 04:32:04,374 --> 04:32:09,880 STUDY ABROAD PROGRAM AND SO I 5794 04:32:09,946 --> 04:32:13,950 JUST WANT TO PROVIDE AN 5795 04:32:14,017 --> 04:32:19,690 EXPERIENCE AND KNOW WHAT IS OUT 5796 04:32:19,756 --> 04:32:25,328 THERE AND WE HAVE COLLABORATION 5797 04:32:25,395 --> 04:32:31,668 IN CHINA AND SO BASICALLY THAT 5798 04:32:31,735 --> 04:32:35,672 IS AND MOST STUDENTS WENT OUT OF 5799 04:32:35,739 --> 04:32:40,143 THE COUNTRY FOR THE FIRST TIME 5800 04:32:40,210 --> 04:32:42,813 AND IT'S AN EXPERIENCE FOR THEM 5801 04:32:42,879 --> 04:32:48,418 TO GET TO KNOW SOME PEOPLE AND 5802 04:32:48,485 --> 04:32:52,189 STUDENTS AND TAKE CLASSES WITH 5803 04:32:52,255 --> 04:32:52,956 PROFESSORERS AND EYE OPENING 5804 04:32:53,023 --> 04:32:54,091 EXPERIENCE FOR THEM AND ALONG 5805 04:32:54,157 --> 04:32:57,461 THE WAY, I KIND OF INTEGRATE MY 5806 04:32:57,527 --> 04:32:58,862 RESEARCH INTO THE CONVERSATION 5807 04:32:58,929 --> 04:32:59,329 WITH THEM. 5808 04:32:59,396 --> 04:33:00,864 I'LL SAY HERE'S WHAT I DO AND 5809 04:33:00,931 --> 04:33:02,432 NOTHING TO DO WITH THE STUDY 5810 04:33:02,499 --> 04:33:03,433 ABROAD PROGRAM BUT HERE'S WHAT I 5811 04:33:03,500 --> 04:33:05,702 DO AND WANT TO INTRODUCE THAT 5812 04:33:05,769 --> 04:33:12,209 AND IT KIND OF STIMULATED THAT 5813 04:33:12,275 --> 04:33:19,683 PROGRAM AND HOW CAN THIS BE 5814 04:33:19,750 --> 04:33:22,018 INCORPORATED TO THEIR OWN AND I 5815 04:33:22,085 --> 04:33:23,687 CANNOT GUARANTEE THAT EVERYBODY 5816 04:33:23,754 --> 04:33:25,889 WILL GO TO MEDICAL SCHOOL OR DO 5817 04:33:25,956 --> 04:33:28,191 RESEARCH AND I THINK THAT IS 5818 04:33:28,258 --> 04:33:31,194 MUCH BROADER IMPACT AND PROVIDE 5819 04:33:31,261 --> 04:33:34,564 TO THE UNDERGRAD EDUCATION AND I 5820 04:33:34,631 --> 04:33:37,968 FEEL LIKE THAT IS AN EXCELLENT 5821 04:33:38,034 --> 04:33:38,268 OPPORTUNITY. 5822 04:33:38,335 --> 04:33:41,705 I'M GRATEFUL I RECEIVED 5823 04:33:41,772 --> 04:33:42,973 DIVERSITY SUPPLEMENT TO SUPPORT 5824 04:33:43,039 --> 04:33:48,245 MY ONGOING RESEARCH PROJECT. 5825 04:33:48,311 --> 04:33:52,649 AND THIS ALLOW MED TO RECRUIT 5826 04:33:52,716 --> 04:33:53,750 UNDERGRAD STUDENTS. 5827 04:33:53,817 --> 04:33:57,220 I WAS NOT VERY BRAD AT 5828 04:33:57,287 --> 04:33:58,889 RECRUITING DOCTORAL STUDENTS I 5829 04:33:58,955 --> 04:34:01,424 KNOW I HAD PLENTY TO CHOOSE 5830 04:34:01,491 --> 04:34:06,129 THERE BUT WAS ABOUT TO RECRUIT 5831 04:34:06,196 --> 04:34:06,530 VARIOUS STUDENTS. 5832 04:34:06,596 --> 04:34:09,299 I SENT THEM OUT TO UNDERGRAD 5833 04:34:09,366 --> 04:34:11,835 STUDENTS IN MY DEPARTMENT AND 5834 04:34:11,902 --> 04:34:13,403 SAID THERE WERE TWO POSITIONS 5835 04:34:13,470 --> 04:34:15,438 AND AVAILABLE AND RECEIVED 18 5836 04:34:15,505 --> 04:34:17,941 APPLICATIONS. 5837 04:34:18,008 --> 04:34:20,210 I NEED TO CHOOSE ONE OUT OF NINE 5838 04:34:20,277 --> 04:34:24,481 FOR THAT AWARD AND I GOT SO MANY 5839 04:34:24,548 --> 04:34:27,217 AND I MADE JUDGMENT TO THE 5840 04:34:27,284 --> 04:34:34,324 BUDGET AND IF YOU'RE LOOK AT THE 5841 04:34:34,391 --> 04:34:35,592 DEMOGRAPHIC BREAKDOWN. 5842 04:34:35,659 --> 04:34:40,664 AND I HAVE HISPANIC MALE AND 5843 04:34:40,730 --> 04:34:43,800 FEMALE AND I TRIED TO DO 5844 04:34:43,867 --> 04:34:45,268 OUTREACH AND RECRUIT EXCELLENT 5845 04:34:45,335 --> 04:34:47,537 STUDENTS AND ESPECIALLY UNDER 5846 04:34:47,604 --> 04:34:49,172 REPRESENTED STUDENTS INTO MY 5847 04:34:49,239 --> 04:34:51,107 RESEARCH AND TRIED TO PROVIDE 5848 04:34:51,174 --> 04:34:54,110 THEM AND RESEARCH TRAINING AND 5849 04:34:54,177 --> 04:34:55,612 HOPEFULLY THEY CAN STAY ON TRACK 5850 04:34:55,679 --> 04:34:57,447 AND BECOME THE NEXT GENERATION 5851 04:34:57,514 --> 04:35:01,184 OF RESEARCHERS. 5852 04:35:01,251 --> 04:35:02,352 THIS HELPED ME SUMMARIZE WHAT I 5853 04:35:02,419 --> 04:35:03,587 DID AS A MENTOR. 5854 04:35:03,653 --> 04:35:07,090 I THINK EVERYBODY IS PROBABLY 5855 04:35:07,157 --> 04:35:11,695 MOST RESEARCHERS IN THE ROOM 5856 04:35:11,761 --> 04:35:13,263 HAVE DONE THIS AND TO SUMMARIZE 5857 04:35:13,330 --> 04:35:15,565 WHAT I DID AND GET INVOLVED IN 5858 04:35:15,632 --> 04:35:17,701 RECRUITMENT AND OUTREACH AND 5859 04:35:17,767 --> 04:35:21,271 TRAINING FOR DATA ANALYSIS AND 5860 04:35:21,338 --> 04:35:22,706 DATA COLLECTION AND ATTENDING 5861 04:35:22,772 --> 04:35:24,074 THE RESEARCH SEMINARS AND 5862 04:35:24,140 --> 04:35:25,642 PRESENTING AT CONFERENCE AND 5863 04:35:25,709 --> 04:35:29,346 TRAINING AT WRITING AND ALSO 5864 04:35:29,412 --> 04:35:31,047 PROMOTE DIVERSITY AND 5865 04:35:31,114 --> 04:35:31,348 ACTIVITIES. 5866 04:35:31,414 --> 04:35:34,017 AND BECAUSE THEY'RE PART OF THAT 5867 04:35:34,084 --> 04:35:36,586 DIVERSITY SUPPLEMENT AND THEY 5868 04:35:36,653 --> 04:35:39,422 SHOULD ACTUALLY REACH OUT AND 5869 04:35:39,489 --> 04:35:40,824 TALK ABOUT WHAT THEY LEARNED AND 5870 04:35:40,891 --> 04:35:43,960 TO CONVEY THAT AND SPREAD THAT 5871 04:35:44,027 --> 04:35:44,961 OUT TO THE KNOWLEDGE AND 5872 04:35:45,028 --> 04:35:47,364 INFORMATION TO OTHER PEOPLE. 5873 04:35:47,430 --> 04:35:49,799 MY HUMBLE EXPERIENCE TOLD ME I 5874 04:35:49,866 --> 04:35:51,234 HAVE TO BE NICE, PATIENT, 5875 04:35:51,301 --> 04:35:59,042 GRATEFUL AND OPEN MINDED. 5876 04:35:59,109 --> 04:36:02,879 I WANT TO USE THIS AT THE BOTTOM 5877 04:36:02,946 --> 04:36:05,715 IMAGE TO SHOW THIS IS MENTORING 5878 04:36:05,782 --> 04:36:06,716 LATE LETTER AT THE FINAL. 5879 04:36:06,783 --> 04:36:11,121 I THINK I'M IN THE MIDDLE NOW. 5880 04:36:11,187 --> 04:36:13,556 AND HOW I MOVED TO THE TOP IS 5881 04:36:13,623 --> 04:36:15,492 ALL LEARNING EXPERIENCE AND WE 5882 04:36:15,558 --> 04:36:16,960 WERE NOT BORN WITH ALL THE 5883 04:36:17,027 --> 04:36:19,229 KNOWLEDGE ABOUT STUDENT 5884 04:36:19,296 --> 04:36:20,697 MENTORING BUT YOU LEARN A LOT OF 5885 04:36:20,764 --> 04:36:24,334 WAYS AND I'M GRATEFUL I HAVE MET 5886 04:36:24,401 --> 04:36:25,502 SO MANY EXCELLENT MENTORS AND 5887 04:36:25,568 --> 04:36:27,904 TRYING TUESDAY MY EXPERIENCE TO 5888 04:36:27,971 --> 04:36:29,472 MENTOR THE NEXT GENERATION OF 5889 04:36:29,539 --> 04:36:35,679 RESEARCHERS AND I WANT TO 5890 04:36:35,745 --> 04:36:36,746 SOMETHING TO UNDER REPRESENTED 5891 04:36:36,813 --> 04:36:37,881 STUDENTS IN THE AUDIENCE. 5892 04:36:37,948 --> 04:36:39,749 YOU HAVE TO THINK BIG AND HIGH. 5893 04:36:39,816 --> 04:36:42,352 RIGHT NOW I'M THE CURRENT SHARE 5894 04:36:42,419 --> 04:36:45,555 AND I NEVER THOUGHT I'D BECOME 5895 04:36:45,622 --> 04:36:54,431 CHAIR AND IT HAPPENS. 5896 04:36:54,497 --> 04:36:57,968 AND AND THE TIME IS TIME 5897 04:36:58,034 --> 04:37:01,805 CONSUMING BUT YOU CAN USE THE 5898 04:37:01,871 --> 04:37:03,807 POSITION TO BENEFIT AND PROVIDE 5899 04:37:03,873 --> 04:37:09,346 SUPPORT TO MANY FACULTY, STAFF, 5900 04:37:09,412 --> 04:37:10,613 STUDENTS TO MOVE THE WHOLE 5901 04:37:10,680 --> 04:37:15,585 PROGRAM AND DEPARTMENT FORWARD 5902 04:37:15,652 --> 04:37:17,053 AND ESTABLISH A WONDERFUL 5903 04:37:17,120 --> 04:37:19,255 PARTNERSHIP AND CONNECTION WITH 5904 04:37:19,322 --> 04:37:19,856 LOCAL COMMUNITIES. 5905 04:37:19,923 --> 04:37:20,724 SO YOU DO SOMETHING BEYOND WHAT 5906 04:37:20,790 --> 04:37:26,096 YOU DO AS A RESEARCHER AND YOU 5907 04:37:26,162 --> 04:37:29,799 CAN REALLY PROMOTE SOMETHING BIG 5908 04:37:29,866 --> 04:37:32,502 AND SO THAT'S THE MESSAGE I WANT 5909 04:37:32,569 --> 04:37:38,608 TO GIVE TO YOUNG GENERATION AND 5910 04:37:38,675 --> 04:37:40,343 IF AN OPPORTUNITY ARISES DON'T 5911 04:37:40,410 --> 04:37:42,746 BE SHY BECAUSE THEY CAN BE 5912 04:37:42,812 --> 04:37:43,580 WONDERFUL OPPORTUNITIES. 5913 04:37:43,646 --> 04:37:45,448 SO CERTAINLY YOU WILL SACRIFICE 5914 04:37:45,515 --> 04:37:47,150 YOUR OWN RESEARCH TO A CERTAIN 5915 04:37:47,217 --> 04:37:47,751 DEGREE. 5916 04:37:47,817 --> 04:37:51,021 BUT YOU CAN PROVIDE MUCH BIGGER 5917 04:37:51,087 --> 04:37:54,124 IMPACT TO YOUR PROGRAM, 5918 04:37:54,190 --> 04:37:55,258 STUDENTS, YOUR INSTITUTION IN 5919 04:37:55,325 --> 04:37:55,959 SOCIETY. 5920 04:37:56,026 --> 04:37:59,696 AND WITH THAT, I WANT TO 5921 04:37:59,763 --> 04:38:02,365 CONCLUDE ONE MY TALK WITH THE 5922 04:38:02,432 --> 04:38:04,100 TWO PICTURES THAT WERE TAKEN 10 5923 04:38:04,167 --> 04:38:04,634 YEARS A PART. 5924 04:38:04,701 --> 04:38:11,541 YOU CAN SEE I SORT OF REALLY 5925 04:38:11,608 --> 04:38:19,983 MATURED OVER THE THREE YEARS BUT 5926 04:38:20,050 --> 04:38:24,754 THE BOLT BOTTOM RIGHT WAS TAKEN 5927 04:38:24,821 --> 04:38:26,389 LAST YEAR AND WE HAD A WONDERFUL 5928 04:38:26,456 --> 04:38:27,757 TIME IF YOU IGNORE THE MESS AT 5929 04:38:27,824 --> 04:38:30,560 THE TABLE AND JUST LOOK AT THE 5930 04:38:30,627 --> 04:38:33,930 SMILES WE HAD WE REALLY ENJOYED 5931 04:38:33,997 --> 04:38:35,665 OURSELVES AND MADE IT A 5932 04:38:35,732 --> 04:38:38,334 WONDERFUL REUNION AND TO KEEP 5933 04:38:38,401 --> 04:38:39,469 REMINDING US WE WERE IN THE SAME 5934 04:38:39,536 --> 04:38:40,804 BOAT AND ARE GOING TO WORK 5935 04:38:40,870 --> 04:38:41,404 TOGETHER AGAIN IN THE FUTURE. 5936 04:38:41,471 --> 04:38:51,648 THANK YOU. 5937 04:39:00,223 --> 04:39:00,690 >> HELLO. 5938 04:39:00,757 --> 04:39:03,359 I'M DR. DERICK FROM UNC CHAPEL 5939 04:39:03,426 --> 04:39:04,928 HILL AN EXCITED TO GIVE YOU AN 5940 04:39:04,994 --> 04:39:06,629 OVERVIEW OF MY EDUCATION AND 5941 04:39:06,696 --> 04:39:08,231 TRAINING TRAJECTORY AND THE ROLE 5942 04:39:08,298 --> 04:39:11,668 MENTORSHIP PLAYED IN MY CAREER 5943 04:39:11,734 --> 04:39:12,635 AS WELL AS A LITTLE SNEAK PEEK 5944 04:39:12,702 --> 04:39:16,339 INTO ANY INCLUDE FUNDED PROJECT 5945 04:39:16,406 --> 04:39:20,577 LOOKING AT C N DYNAMICS IN 5946 04:39:20,643 --> 04:39:21,177 CHILDREN WITH DOWN SYNDROME. 5947 04:39:21,244 --> 04:39:22,712 MY EDUCATION TRAJECTORY STARTED 5948 04:39:22,779 --> 04:39:24,013 AT THE UNIVERSITY OF FLORIDA 5949 04:39:24,080 --> 04:39:28,551 WHERE I GOT MY BACHELOR'S OF 5950 04:39:28,618 --> 04:39:29,819 SCIENCE I HAVE THE GREAT 5951 04:39:29,886 --> 04:39:30,987 PRIVILEGE OF BEING ABLE TO 5952 04:39:31,054 --> 04:39:33,356 PARTICIPATE IN RESEARCH MANY 5953 04:39:33,423 --> 04:39:34,691 LABS AND MULTIPLE UNIVERSITIES 5954 04:39:34,757 --> 04:39:40,196 DURING MY FOUR YEARS. 5955 04:39:40,263 --> 04:39:44,033 THERE'S ONE MENTOR WHO MADE THE 5956 04:39:44,100 --> 04:39:46,603 BIGGEST IMPACT DR. SCOTT MILLER. 5957 04:39:46,669 --> 04:39:48,605 I SPENT THREE AND A HALF YEARS 5958 04:39:48,671 --> 04:39:49,739 BEING A RESEARCH ASSISTANT IN 5959 04:39:49,806 --> 04:39:54,544 HIS LAB AND WHILE HE DID A GREAT 5960 04:39:54,611 --> 04:39:57,113 JOB IN CHILD PSYCHOLOGY AND 5961 04:39:57,180 --> 04:39:57,914 CHILD DEVELOPMENT, I THINK WHAT 5962 04:39:57,981 --> 04:39:59,649 I TOOK AWAY IS HOW TO THINK 5963 04:39:59,716 --> 04:40:01,985 ABOUT RESEARCH. 5964 04:40:02,051 --> 04:40:05,388 ME MENTORED MY HONOR THESIS AND 5965 04:40:05,455 --> 04:40:06,356 SPARK AN INTEREST THAT SPARK THE 5966 04:40:06,422 --> 04:40:09,092 REST OF MY ACADEMIC CAREER. 5967 04:40:09,159 --> 04:40:10,627 ONE QUALITY THAT REALLY STUCK 5968 04:40:10,693 --> 04:40:15,165 OUT ABOUT HIM WAS HE FOSTERED 5969 04:40:15,231 --> 04:40:16,032 ANY INDIVIDUAL INTERESTS I HAD 5970 04:40:16,099 --> 04:40:17,634 AND WHEN I HAD ONE OUT OF HIS 5971 04:40:17,700 --> 04:40:24,007 SPOKE WHICH WAS OFTEN AT 19, HE 5972 04:40:24,073 --> 04:40:26,376 ENCOURAGED ME TO SEEK OUT OTHER 5973 04:40:26,442 --> 04:40:28,278 LABS AND THAT HELPED ME LEARN 5974 04:40:28,344 --> 04:40:29,846 ABOUT NOT ONLY OTHER RESEARCH 5975 04:40:29,913 --> 04:40:32,248 APPROACHES BUT GAIN EXPERIENCE 5976 04:40:32,315 --> 04:40:33,850 IN OTHER LABS IN ORDER TO LEARN 5977 04:40:33,917 --> 04:40:36,786 WHAT LAB STRUCTURE AND MENTORING 5978 04:40:36,853 --> 04:40:38,488 STYLE WORKS BEST FOR ME AND 5979 04:40:38,555 --> 04:40:40,223 SOMETHING I STILL ENCOURAGE 5980 04:40:40,290 --> 04:40:42,225 GRADUATE STUDENTS AND UNDER 5981 04:40:42,292 --> 04:40:43,760 GRADS TODAY. 5982 04:40:43,826 --> 04:40:45,461 IT'S ONE OF THE MOST IMPORTANT 5983 04:40:45,528 --> 04:40:49,299 THINGS ABOUT FINDING A RESEARCH 5984 04:40:49,365 --> 04:40:51,434 TEAM IS A GOOD FIT ON TOP OF 5985 04:40:51,501 --> 04:40:52,468 EVERYTHING ELSE. 5986 04:40:52,535 --> 04:40:53,703 ALL THOSE EXPERIENCE PREPARED ME 5987 04:40:53,770 --> 04:40:55,672 WELL TO CHOOSE A GRADUATE 5988 04:40:55,738 --> 04:40:58,274 PROGRAM. 5989 04:40:58,341 --> 04:41:01,945 I ENDED UP GOING TO FLORIDA 5990 04:41:02,011 --> 04:41:04,247 INTERNATIONAL UNIVERSITY FOR MY 5991 04:41:04,314 --> 04:41:05,682 MASTER'S Ph.D. AND UNDER 5992 04:41:05,748 --> 04:41:08,351 UNDERGRAD I WAS CERTAIN I WANTED 5993 04:41:08,418 --> 04:41:11,921 TO DEVOTE MY CAREER TO LOOK AT 5994 04:41:11,988 --> 04:41:14,057 CHILD DEVELOPMENT AND NEXT STEP 5995 04:41:14,123 --> 04:41:17,894 WAS CHILD DEVELOPMENT AND CHOSE 5996 04:41:17,961 --> 04:41:19,896 ANTHONY DICK AS ANY TRAINING 5997 04:41:19,963 --> 04:41:23,299 MENTOR AND GIVE THEM CREDIT 5998 04:41:23,366 --> 04:41:24,133 BECAUSE I HAD ZERO EXPERIENCE IN 5999 04:41:24,200 --> 04:41:26,002 NEUROSCIENCE AND HE TOOK A BIG 6000 04:41:26,069 --> 04:41:27,570 RISK AND TRAINED ME FROM THE 6001 04:41:27,637 --> 04:41:27,971 GROUND UP. 6002 04:41:28,037 --> 04:41:31,107 ACROSS THE FIVE YEARS I LEARNED 6003 04:41:31,174 --> 04:41:32,542 ABOUT NEURO IMAGING AND BRAIN 6004 04:41:32,609 --> 04:41:36,713 DEVELOPMENT AN GOT TO WORK ON A 6005 04:41:36,779 --> 04:41:39,716 FEW FUN PROJECTS. 6006 04:41:39,782 --> 04:41:44,687 I LEARNED HOW TO MAP OUT 6007 04:41:44,754 --> 04:41:48,091 NEURONAL DENSITY IN CHILDREN AND 6008 04:41:48,157 --> 04:41:51,060 ADULTS AND WENT TO MAPPING THE 6009 04:41:51,127 --> 04:41:55,798 STRUCTURAL CONNECTOME OF THE 6010 04:41:55,865 --> 04:41:55,999 BRAIN. 6011 04:41:56,065 --> 04:42:02,905 DURING THE PROJECTS AND LOOKING 6012 04:42:02,972 --> 04:42:05,275 AT CLINICAL IMPLICATIONS WHICH 6013 04:42:05,341 --> 04:42:06,843 ARE THE NEXT STEP OF NEURAL 6014 04:42:06,909 --> 04:42:07,110 IMAGING. 6015 04:42:07,176 --> 04:42:11,247 WHAT'S IT MEAN FOR A CLINICIAN 6016 04:42:11,314 --> 04:42:12,248 OUTSIDE THE LAB? 6017 04:42:12,315 --> 04:42:14,384 I NEEDED MORE CLINICAL TRAINING. 6018 04:42:14,450 --> 04:42:15,685 UP TO THAT POINT EVERYTHING I'VE 6019 04:42:15,752 --> 04:42:17,687 DONE IS NORMATIVE TRAJECTORIES 6020 04:42:17,754 --> 04:42:19,222 AND I NEEDED ADDITIONAL CLINICAL 6021 04:42:19,289 --> 04:42:19,689 TRAINING TO DRAW THE 6022 04:42:19,756 --> 04:42:29,999 IMPLICATIONS. 6023 04:42:31,801 --> 04:42:36,139 AND A CLINICAL PSYCHOLOGIST THAT 6024 04:42:36,205 --> 04:42:39,142 STUDIES YOUNG CHILDREN WAS A 6025 04:42:39,208 --> 04:42:40,910 CO-MENTOR AND I HAD A CLINICIAN 6026 04:42:40,977 --> 04:42:43,880 TO HELP ME DRAW THE CONCLUSIONS. 6027 04:42:43,946 --> 04:42:46,516 AND DURING THE LAST YEAR OF 6028 04:42:46,582 --> 04:42:48,651 GRADUATE SCHOOL I GOT TO 6029 04:42:48,718 --> 04:42:50,653 COLLABORATE ON VERY FUN PROJECTS 6030 04:42:50,720 --> 04:42:54,090 LOOKING AT BIOMARKERS AND NEURO 6031 04:42:54,157 --> 04:42:57,760 IMAGING FOR ADHD SYMPTOMS AND 6032 04:42:57,827 --> 04:43:00,163 FIBER TRACTOGRAPHY TO TRACT 6033 04:43:00,229 --> 04:43:00,463 TRAITS. 6034 04:43:00,530 --> 04:43:02,198 I KNEW BY THE END OF MY Ph.D. I 6035 04:43:02,265 --> 04:43:02,732 NEEDED MORE. 6036 04:43:02,799 --> 04:43:04,701 AFTER ONE YEAR OF CLINICAL 6037 04:43:04,767 --> 04:43:07,403 TRAINING I KNEW I WANTED TO LOOK 6038 04:43:07,470 --> 04:43:09,105 INTO POSTDOC TRAININGS TO ALLOW 6039 04:43:09,172 --> 04:43:10,673 ME TO EXPAND THIS. 6040 04:43:10,740 --> 04:43:14,377 I WAS INTERESTED IN NEURAL 6041 04:43:14,444 --> 04:43:15,378 DEVELOPMENTAL DISORDERS AND 6042 04:43:15,445 --> 04:43:17,814 BEING ABLE TO DOWNWARD EXTEND MY 6043 04:43:17,880 --> 04:43:22,785 EXPERIENCE IN NEURAL IMAGING AND 6044 04:43:22,852 --> 04:43:25,154 GOT INTERESTED IN WHAT IT WOULD 6045 04:43:25,221 --> 04:43:27,323 BE LIKE TO SCAN AN INFANT BEFORE 6046 04:43:27,390 --> 04:43:28,891 SYMPTOMS APPEAR. 6047 04:43:28,958 --> 04:43:30,193 THAT'S WHAT STUCK OUT TO ME 6048 04:43:30,259 --> 04:43:34,430 ABOUT UNC CHAPEL HILL. 6049 04:43:34,497 --> 04:43:38,701 I END UP IN A POSTDOC THERE AND 6050 04:43:38,768 --> 04:43:41,838 PURSUED A T32 SCHOLARSHIP IN 6051 04:43:41,904 --> 04:43:43,239 NEURAL DEVELOPMENTAL DISORDERS 6052 04:43:43,306 --> 04:43:45,541 BY NICHD AND I CANNOT RECOMMEND 6053 04:43:45,608 --> 04:43:45,875 THEM ENOUGH. 6054 04:43:45,942 --> 04:43:47,343 THEY'RE AN EXCELLENT RESOURCE 6055 04:43:47,410 --> 04:43:48,811 BECAUSE UNLIKE A TRADITIONAL 6056 04:43:48,878 --> 04:43:50,646 POSTDOC WHERE YOU TAKE ON A FULL 6057 04:43:50,713 --> 04:43:53,249 TIME JOB AND JOIN A LAB, A T32 6058 04:43:53,316 --> 04:43:55,618 IS A COMBINATION OF TRAINING AND 6059 04:43:55,685 --> 04:43:55,885 RESEARCH. 6060 04:43:55,952 --> 04:43:58,187 I HAD DIDACTIC TRAINING WITH 6061 04:43:58,254 --> 04:44:00,356 COURSE WORK AND HANDS-ON 6062 04:44:00,423 --> 04:44:01,924 EXPERIENCE IN A LAB AS WELL AS 6063 04:44:01,991 --> 04:44:04,193 SCANNER WHICH GAVE ME A WIDE 6064 04:44:04,260 --> 04:44:05,027 BREADTH OF EXPERIENCE IN JUST 6065 04:44:05,094 --> 04:44:09,732 TWO YEARS OF TIME. 6066 04:44:09,799 --> 04:44:12,268 I DECIDED TO FOLLOW A 6067 04:44:12,335 --> 04:44:14,670 CO-MENTORSHIP MODEL SINCE I TOWN 6068 04:44:14,737 --> 04:44:16,973 IT WORKED WELL FOR ANY 6069 04:44:17,039 --> 04:44:18,908 DISSERTA 6070 04:44:18,975 --> 04:44:19,242 DISSERTATION. 6071 04:44:19,308 --> 04:44:23,346 THE MORE SPEEDBACK YOU GET IT 6072 04:44:23,413 --> 04:44:26,916 CAN GIVE YOU -- FEEDBACK GIVES A 6073 04:44:26,983 --> 04:44:27,683 UNIQUE PERSPECTIVE WHEN YOU 6074 04:44:27,750 --> 04:44:29,752 COMBINE PEOPLE FROM OTHER AREAS 6075 04:44:29,819 --> 04:44:30,186 OF EXPERTISE. 6076 04:44:30,253 --> 04:44:33,823 I WORKED WITH A CLINICAL NEURAL 6077 04:44:33,890 --> 04:44:35,825 SCIENTIST AND DOES TRANSLATIONAL 6078 04:44:35,892 --> 04:44:39,862 NEURAL SCIENTIST AND A RENOWN 6079 04:44:39,929 --> 04:44:48,104 PSYCHIATRIST AND EXPERT IN 6080 04:44:48,171 --> 04:44:48,404 AUTISM. 6081 04:44:48,471 --> 04:44:51,674 I'LL GIVE A BRIEF OVERVIEW OF 6082 04:44:51,741 --> 04:45:01,184 CSF DYNAMICS AND PIMPLICATIONS. 6083 04:45:01,250 --> 04:45:02,185 CEREBROSPINAL FLUID IS GET 6084 04:45:02,251 --> 04:45:03,319 ATTENTION DUE TO THE REDISCOVERY 6085 04:45:03,386 --> 04:45:04,921 OF THE LYMPHATIC SYSTEM. 6086 04:45:04,987 --> 04:45:07,290 THE ROLE OF CSF IN THE BRAIN IS 6087 04:45:07,356 --> 04:45:11,260 TO BE A WASTE CLEARANCE PATHWAY 6088 04:45:11,327 --> 04:45:13,396 AND NOT ONLY DISTRIBUTE THOSE 6089 04:45:13,463 --> 04:45:15,298 GROWTH FACTORS TO THE BRAIN BUT 6090 04:45:15,364 --> 04:45:20,102 REMOVES AMYLOID BETA. 6091 04:45:20,169 --> 04:45:26,075 GIVEN THE ASSOCIATION WITH IT 6092 04:45:26,142 --> 04:45:31,180 THIS ALMOST ALL RESEARCH LOOKED 6093 04:45:31,247 --> 04:45:33,182 AT THIS IN ALZHEIMER'S. 6094 04:45:33,249 --> 04:45:35,451 THERE'S A LARGE GAP IN 6095 04:45:35,518 --> 04:45:36,719 UNDERSTANDING WHAT THEY LOOK 6096 04:45:36,786 --> 04:45:39,155 LIKE IN EARLY LIFE. 6097 04:45:39,222 --> 04:45:44,827 OUR LAB AT UNC LOOKED AT THIS IN 6098 04:45:44,894 --> 04:45:46,863 INFANCY AND WHAT YOU SEE IN THE 6099 04:45:46,929 --> 04:45:51,534 BOTTOM THREE BRAINS IS INFANT 6100 04:45:51,601 --> 04:45:52,502 WHO WENT ON TO DEVELOP AUTISM 6101 04:45:52,568 --> 04:45:54,604 AND THEN SEE A TYPICALLY 6102 04:45:54,670 --> 04:45:56,072 DEVELOPING INFANT. 6103 04:45:56,138 --> 04:45:58,808 THE THING THAT JUMPS OUT IS THE 6104 04:45:58,875 --> 04:46:00,076 EXTRA AXIAL CSF. 6105 04:46:00,143 --> 04:46:03,813 WHAT WE SEE IS AN INCREASE OF 6106 04:46:03,880 --> 04:46:06,148 CSF ACCUMULATING AS EARLY AS SIX 6107 04:46:06,215 --> 04:46:08,451 MONTHS OF AGE, YEARS BEFORE 6108 04:46:08,518 --> 04:46:09,452 TYPICAL SYMPTOMS APPEAR. 6109 04:46:09,519 --> 04:46:11,721 THAT'S NOW BEEN REPLICATED AMONG 6110 04:46:11,787 --> 04:46:15,691 THREE STUDIES AND COHORTS AND 6111 04:46:15,758 --> 04:46:25,101 HAPPENS TO BE VERY REPLY -- 6112 04:46:25,167 --> 04:46:27,670 REPLICABLE AND I LOOKED AT CSF 6113 04:46:27,737 --> 04:46:27,937 DYNAMICS. 6114 04:46:28,004 --> 04:46:30,773 I HAD A RECENT PAPER WHERE I 6115 04:46:30,840 --> 04:46:32,208 LOOKED AT VASCULAR SPACES WHICH 6116 04:46:32,275 --> 04:46:41,584 SEE AN ANIMATION OF HERE. 6117 04:46:41,651 --> 04:46:43,319 THEY'RE TYPICALLY VIEWED AS 6118 04:46:43,386 --> 04:46:48,558 MARKERS OF VARADIATION. 6119 04:46:48,624 --> 04:46:51,727 IT'S A SIGN OF BRAIN AGING. 6120 04:46:51,794 --> 04:46:54,397 THE STUDY SHOWED ALMOST HALF OF 6121 04:46:54,463 --> 04:46:57,833 2-YEAR-OLD GOOD ON TO DEVELOP 6122 04:46:57,900 --> 04:47:01,671 AUTISM HAVE LARGE PBS BY THE 6123 04:47:01,737 --> 04:47:03,506 TIME THEY'RE 24 MONTHS OF AGE 6124 04:47:03,573 --> 04:47:04,507 AND AN EARLY BIOMARKER OF THE 6125 04:47:04,574 --> 04:47:04,774 DISORDER. 6126 04:47:04,840 --> 04:47:07,476 WHEN PUT THAT TOGETHER WE'RE 6127 04:47:07,543 --> 04:47:10,646 SAYING AN ACCUMULATION OF CSF 6128 04:47:10,713 --> 04:47:13,316 AND HAVE EVIDENCE OF IMPAIRED 6129 04:47:13,382 --> 04:47:14,317 CSF FLOW. 6130 04:47:14,383 --> 04:47:17,019 WE HAVE AN OVER ALL NARRATIVE OF 6131 04:47:17,086 --> 04:47:26,128 DYNAMICS IN AUTISM. 6132 04:47:26,195 --> 04:47:27,530 IS THIS AUTISM SPECIFIC? 6133 04:47:27,597 --> 04:47:34,937 AUR TEAM THINKSES -- THINK NO. 6134 04:47:35,004 --> 04:47:38,341 WE THINK THERE'S SHARED 6135 04:47:38,407 --> 04:47:39,041 PATHOPHYSIOLOGY. 6136 04:47:39,108 --> 04:47:42,211 WE LOOKED AT SYNDROMES, FOR 6137 04:47:42,278 --> 04:47:44,580 EXAMPLE, FRAGILE X WHERE WE SEE 6138 04:47:44,647 --> 04:47:47,683 THIS AT THE TOP WHAT YOU SEE IS 6139 04:47:47,750 --> 04:47:51,153 THAT INFANTS NOT ONLY HAVE MORE 6140 04:47:51,220 --> 04:47:51,754 EACSF BUT MORE THAN AUTISM AS 6141 04:47:51,821 --> 04:48:01,931 WELL. 6142 04:48:04,800 --> 04:48:06,669 WE ALSO SEE THE PATTERN IN 6143 04:48:06,736 --> 04:48:08,638 FRAGILE X AS WELL. 6144 04:48:08,704 --> 04:48:10,339 ALL THIS PUT TOGETHER MEANS IT'S 6145 04:48:10,406 --> 04:48:13,376 MOST LIKELY NOT AUTISM SPECIFIC 6146 04:48:13,442 --> 04:48:17,046 AND BASICALLY AN ABNORMAL 6147 04:48:17,113 --> 04:48:19,448 PATHWAY AND A SIGN NEURAL 6148 04:48:19,515 --> 04:48:20,750 DEVELOPMENTAL DISORDER TAKING 6149 04:48:20,816 --> 04:48:26,989 PLACE BRINGING ME TO THE MOST 6150 04:48:27,056 --> 04:48:27,690 EXCITING PEOPLE AND THEY'RE 6151 04:48:27,757 --> 04:48:31,127 LOOKING AT THE DYNAMICS TO DOWN 6152 04:48:31,193 --> 04:48:34,797 SYNDROME DON'T HAVE TO TELL THIS 6153 04:48:34,864 --> 04:48:38,234 AUDIENCE BUT IT'S A MODEL TO 6154 04:48:38,300 --> 04:48:42,038 EXAMINE CSF DYNAMICS AND HAVE 6155 04:48:42,104 --> 04:48:43,506 EARLY ONSET ALZHEIMER'S, 6156 04:48:43,572 --> 04:48:45,374 INDIVIDUALS WITH DOWNS SYNDROME 6157 04:48:45,441 --> 04:48:47,076 ARE 15 TIMES MORE LIKELY TO 6158 04:48:47,143 --> 04:48:47,843 DEVELOP AUTISM. 6159 04:48:47,910 --> 04:48:51,147 SO WITH A COMBINATION OF RISK 6160 04:48:51,213 --> 04:48:53,315 FOR AUTISM AND ALZHEIMER'S, WE 6161 04:48:53,382 --> 04:48:56,118 HAVE REASON TO BELIEVE THERE'S 6162 04:48:56,185 --> 04:48:57,119 DYNAMICS AT PLAY. 6163 04:48:57,186 --> 04:48:58,688 SO I USE INCLUDE FUNDING. 6164 04:48:58,754 --> 04:49:01,724 I'M DOING A FIVE-YEAR STUDY TO 6165 04:49:01,791 --> 04:49:09,799 EXAMINE CSF TRA JEJECTORIES TO K 6166 04:49:09,865 --> 04:49:13,669 AT INTERIM BIOMARKERS AND 6167 04:49:13,736 --> 04:49:15,471 THERAPEUTICS INTRAFECAL 6168 04:49:15,538 --> 04:49:16,739 THERAPEUTIC REQUIRE A KNOWLEDGE 6169 04:49:16,806 --> 04:49:19,241 OF CSF DYNAMICS. 6170 04:49:19,308 --> 04:49:21,844 RIGHT NOW IT'S ALMOST EXCLUSIVE 6171 04:49:21,911 --> 04:49:25,915 TO ADULTS. 6172 04:49:26,282 --> 04:49:28,951 AND THAT I HAVE A CAREER 6173 04:49:29,018 --> 04:49:30,286 DEVELOPMENT AWARD MENTIONED 6174 04:49:30,352 --> 04:49:36,258 FUNDED BY INCLUDE NICHD. 6175 04:49:36,325 --> 04:49:38,928 AND I GET TO COMBINE NOT ONLY MY 6176 04:49:38,994 --> 04:49:39,829 FIVE-YEAR RESEARCH PROJECT BUT 6177 04:49:39,895 --> 04:49:43,666 ALSO FIVE YEARS OF EXTENSIVE 6178 04:49:43,733 --> 04:49:44,200 TRAINING. 6179 04:49:44,266 --> 04:49:45,835 I'M USING THIS TRAINING TIME IN 6180 04:49:45,901 --> 04:49:51,841 ORDER TO EXPAND CLINICAL AND 6181 04:49:51,907 --> 04:49:57,847 PRE-CLINICAL TRAINING. 6182 04:49:57,913 --> 04:50:00,416 AND NOW I WORK WITH INDIVIDUALS 6183 04:50:00,483 --> 04:50:01,951 WITH DOWN SYNDROME AND FOR THE 6184 04:50:02,017 --> 04:50:03,652 FIRST TIME I'M TRYING TO SPEND 6185 04:50:03,719 --> 04:50:09,792 EYE -- A DECENT AMOUNT OF TIME 6186 04:50:09,859 --> 04:50:12,795 WITH PRE-CLINICAL TRAINING AND 6187 04:50:12,862 --> 04:50:14,196 MOUSE MODELS ARE IMPORTANT IN A 6188 04:50:14,263 --> 04:50:17,032 NOVEL FIELD FOR ME. 6189 04:50:17,099 --> 04:50:21,771 I'VE BEEN SPENDING TIME BEING 6190 04:50:21,837 --> 04:50:24,039 TRAINED IN THAT SO DO MORE 6191 04:50:24,106 --> 04:50:26,142 COLLABORATORY WORK AND I'M 6192 04:50:26,208 --> 04:50:29,411 LOOKING AT CSF DYNAMICS ACROSS 6 6193 04:50:29,478 --> 04:50:32,281 TO 24 MONTHS IN INFANTS WITH 6194 04:50:32,348 --> 04:50:35,651 DOWN SYNDROME TO RELATE IT TO 6195 04:50:35,718 --> 04:50:38,788 LATER NEURAL OUTCOMES PRIMARILY 6196 04:50:38,854 --> 04:50:39,789 WHITE MATTER AND NEURAL DENSE 6197 04:50:39,855 --> 04:50:39,955 SI. 6198 04:50:40,022 --> 04:50:42,258 IF YOU'RE INTERESTED I HAVE A 6199 04:50:42,324 --> 04:50:43,793 POSTER TODAY AT 3:30. 6200 04:50:43,859 --> 04:50:46,762 MORE INFORMATION ON THAT. 6201 04:50:46,829 --> 04:50:51,333 AND I'M ALSO TO LOOK AT CSF IN 6202 04:50:51,400 --> 04:50:57,840 RELATION TO CLINICAL OUTCOMES 6203 04:50:57,907 --> 04:50:59,742 AND MOTOR AND COGNITIVE AND 6204 04:50:59,809 --> 04:51:01,110 SLEEP OUTCOME. 6205 04:51:01,177 --> 04:51:03,646 AND I HAVE A GREAT TEAM WHO 6206 04:51:03,712 --> 04:51:06,949 AGREED TO HELP ME IN THE 6207 04:51:07,016 --> 04:51:07,516 PROCESS. 6208 04:51:07,583 --> 04:51:09,852 FAMILIAR NAME I BROUGHT UP HAVE 6209 04:51:09,919 --> 04:51:11,821 CONTINUED BEING MY POSTDOC 6210 04:51:11,887 --> 04:51:14,323 MENTORS TO MY K1 MENTORS AND 6211 04:51:14,390 --> 04:51:16,759 I'VE ALSO ADDED A CO-MENTOR WHO 6212 04:51:16,826 --> 04:51:21,597 IS A CREDITED TO BE ONE OF THE 6213 04:51:21,664 --> 04:51:23,299 CO-DISCOVERIES OF THE SYSTEM AND 6214 04:51:23,365 --> 04:51:26,368 HE'S A CSF EXPERT AND WORKS IN 6215 04:51:26,435 --> 04:51:27,603 THE ALZHEIMER'S FIELD AND IS 6216 04:51:27,670 --> 04:51:30,039 PURELY A PRE-CLINICAL SCIENTIST 6217 04:51:30,105 --> 04:51:32,808 SO HE WORKS PRIME IERL WITH 6218 04:51:32,875 --> 04:51:33,676 RODENT MODELS AND THROUGH 6219 04:51:33,742 --> 04:51:34,810 INCLUDE FUNDING I HAD THE 6220 04:51:34,877 --> 04:51:36,278 PRIVILEGE OF SPENDING FOUR WEEKS 6221 04:51:36,345 --> 04:51:39,648 IN HIS LAB IN THE UNIVERSITY OF 6222 04:51:39,715 --> 04:51:44,486 WASHINGTON WITH TRAINING IN HIS 6223 04:51:44,553 --> 04:51:47,056 V.A. LAB TO LOOK AT HOW CSF 6224 04:51:47,122 --> 04:51:50,192 STUDIES HAVE DONE IN RODENTS 6225 04:51:50,259 --> 04:51:51,694 HELPING SHAPE THE QUESTIONS WE 6226 04:51:51,760 --> 04:51:53,495 ASK AND IT'S DIFFERENT SEEING IN 6227 04:51:53,562 --> 04:51:55,698 AN ANIMAL THAN MAKING 6228 04:51:55,764 --> 04:51:56,599 ASSUMPTIONS BASED ON MRI. 6229 04:51:56,665 --> 04:51:57,399 AS THE BEEN A VERY HELPFUL 6230 04:51:57,466 --> 04:52:06,575 EXPERIENCE. 6231 04:52:06,642 --> 04:52:11,680 AND THE CSF OF DYNAMICS ARE 6232 04:52:11,747 --> 04:52:14,617 ABERRANT IN PEOPLE WITH WHO 6233 04:52:14,683 --> 04:52:15,417 DEVELOP DOWN SYNDROME AND THIS 6234 04:52:15,484 --> 04:52:18,921 WILL BE THE FIRST STUDIO TO USE 6235 04:52:18,988 --> 04:52:23,959 HIGH ORDER DIFFUSION MODELS AND 6236 04:52:24,026 --> 04:52:27,696 LOPE LOOK AT DISEASE PROGRESSION 6237 04:52:27,763 --> 04:52:29,064 AND TARGETED THERAPEUTICS. 6238 04:52:29,131 --> 04:52:30,866 ONE OF THE BIGGEST THINGS I WANT 6239 04:52:30,933 --> 04:52:33,769 IT LEAVE YOU WITH IS WHILE I 6240 04:52:33,836 --> 04:52:35,671 FEEL VERY FORTUNATE TO HAVE HAD 6241 04:52:35,738 --> 04:52:37,306 THE FOUNDATIONAL TRAINING I'VE 6242 04:52:37,373 --> 04:52:38,741 HAD, I THINK IT'S THE PEOPLE 6243 04:52:38,807 --> 04:52:41,110 THAT MADE THE LARGEST IMPACT 6244 04:52:41,176 --> 04:52:42,878 ALONG THIS WAY STARTING FROM MY 6245 04:52:42,945 --> 04:52:44,947 GRADUATE LAB WHO I STILL HAVE 6246 04:52:45,014 --> 04:52:45,981 THE PLEASURE OF SEEING AT ALMOST 6247 04:52:46,048 --> 04:52:50,986 EVERY CONFERENCE I GO TO AND 6248 04:52:51,053 --> 04:52:53,822 FEEL FREE TO ASK PEOPLE OUTSIDE 6249 04:52:53,889 --> 04:52:59,662 YOUR LOOK AT YOUR SPECIFIC AIMS 6250 04:52:59,728 --> 04:53:01,864 AND SOMEBODY WHO IS NOT IN YOUR 6251 04:53:01,931 --> 04:53:03,565 FIELD CAN GIVE VALUABLE FEEDBACK 6252 04:53:03,632 --> 04:53:12,975 ON THE IMPLICATIONS AND IT'S 6253 04:53:13,042 --> 04:53:21,884 IMPORTANT TO GET FEEDBACK FROM 6254 04:53:21,951 --> 04:53:23,819 THOSE NOT IN YOUR FIELD AND 6255 04:53:23,886 --> 04:53:25,254 SMALL AND LARGE NETWORKS MADE A 6256 04:53:25,321 --> 04:53:29,892 HUGE IMPACT ON MY WORK. 6257 04:53:29,959 --> 04:53:33,195 I JUST MADE THESE QUICK OVERVIEW 6258 04:53:33,262 --> 04:53:34,363 OF THE MENTORSHIPS. 6259 04:53:34,430 --> 04:53:36,165 ONE BIG THING IS SEEK OUT 6260 04:53:36,231 --> 04:53:39,668 MENTORS SUPPORTIVE OF GROWING 6261 04:53:39,735 --> 04:53:49,378 INTERESTS. 6262 04:53:49,445 --> 04:53:57,886 I HIGHLY RECOMMEND CO OR 6263 04:53:57,953 --> 04:53:59,688 MULTI-MEMBE 6264 04:53:59,755 --> 04:54:02,358 MULTI-MEMBERSHIP MODELS AND NOT 6265 04:54:02,424 --> 04:54:04,326 LIMIT YOURSELF GEOGRAPHICALLY 6266 04:54:04,393 --> 04:54:07,696 AND MAKE MENTORSHIP WORK ACROSS 6267 04:54:07,763 --> 04:54:08,897 UNIVERSITIES AND DISTANCES. 6268 04:54:08,964 --> 04:54:14,269 I PLAN TO TAKE ALL OF THE WORK 6269 04:54:14,336 --> 04:54:17,139 I'M DOING NOW AND USE IT FOR 6270 04:54:17,206 --> 04:54:23,512 PRELIMINARY DATA FOR A RO1 OR 6271 04:54:23,579 --> 04:54:25,381 TWO AND HUGE SHOUT OUT TO THE 6272 04:54:25,447 --> 04:54:27,516 FAMILIES AND INFANTS WHO 6273 04:54:27,583 --> 04:54:29,184 CONTINUE TO PARTICIPATE AND 6274 04:54:29,251 --> 04:54:30,052 COLLABORATORS WHO CONTRIBUTED TO 6275 04:54:30,119 --> 04:54:30,652 EVERYTHING WE'VE DONE SO FAR. 6276 04:54:30,719 --> 04:54:40,896 THANK YOU. 6277 04:54:49,805 --> 04:54:55,644 >> THANK YOU TO DR. GEHRIG AND 6278 04:54:55,711 --> 04:54:57,913 WU AND I WANT TO KNOW HOW MANY 6279 04:54:57,980 --> 04:55:00,249 IDENTIFY AS STUDENTS, TRAINEES, 6280 04:55:00,315 --> 04:55:03,485 GRADUATE STUDENTS, POSTDOCS? 6281 04:55:03,552 --> 04:55:06,355 AND HOW MANY HAVE GRADUATES AND 6282 04:55:06,422 --> 04:55:07,589 TRAINEES IN YOUR LAB? 6283 04:55:07,656 --> 04:55:09,892 THIS IS RELEVANT TO EVERYONE IN 6284 04:55:09,958 --> 04:55:10,459 THE ROOM. 6285 04:55:10,526 --> 04:55:14,830 I KNOW WE ARE CUTTING CLOSE TO 6286 04:55:14,897 --> 04:55:19,301 THE TIME SO I AM ONE OF THE 6287 04:55:19,368 --> 04:55:21,236 PROGRAM DIRECTORS AT NICHD AND A 6288 04:55:21,303 --> 04:55:23,672 MEMBER OF THE INCLUDE PROJECT 6289 04:55:23,739 --> 04:55:30,913 TEAM. 6290 04:55:30,979 --> 04:55:33,048 AND YOU INTEREST TRAINEES AND 6291 04:55:33,115 --> 04:55:33,882 INVESTIGATORS IN THE DOWN 6292 04:55:33,949 --> 04:55:37,586 SYNDROME ECO SYSTEM. 6293 04:55:37,653 --> 04:55:42,424 AND THIS IS A GREAT TOOL FROM 6294 04:55:42,491 --> 04:55:43,158 NIH. 6295 04:55:43,225 --> 04:55:47,096 THESE ARE RECEIVERS FOR 6296 04:55:47,162 --> 04:55:47,830 UNDERGRADUATES AND GRADUATE 6297 04:55:47,896 --> 04:55:57,372 STUDENTS, POSTDOCS, EARLY CAREER 6298 04:55:57,439 --> 04:55:59,641 TRAINEES AND INVESTIGATORS AND 6299 04:55:59,708 --> 04:56:01,343 HAVE INITIATIVES AND MECHANISMS. 6300 04:56:01,410 --> 04:56:07,149 I WILLING GIVE A SUMMARY OF THE 6301 04:56:07,216 --> 04:56:08,350 NIH ALPHABET SOUP FOR MECHANISMS 6302 04:56:08,417 --> 04:56:10,886 BUT NOT ALL AND IT'S A GREAT 6303 04:56:10,953 --> 04:56:12,721 RESOURCE AND WE HAVE THE INCLUDE 6304 04:56:12,788 --> 04:56:15,724 WEBSITE WHERE WE POST ANY 6305 04:56:15,791 --> 04:56:17,993 FUNDING OPPORTUNITIES THAT WE 6306 04:56:18,060 --> 04:56:18,494 PUBL 6307 04:56:18,560 --> 04:56:18,727 PUBLISH. 6308 04:56:18,794 --> 04:56:21,964 THESE ARE TWO GREAT RESOURCES. 6309 04:56:22,030 --> 04:56:24,533 THIS INFO GRAPHIC TAKES US 6310 04:56:24,600 --> 04:56:27,069 THROUGH THE CAREER STAGES OF 6311 04:56:27,136 --> 04:56:27,669 TRAINEES START FROM 6312 04:56:27,736 --> 04:56:29,972 UNDERGRADUATE TO GRADUATE AND 6313 04:56:30,038 --> 04:56:32,774 POST-DOCTORAL AND RESIDENCY AND 6314 04:56:32,841 --> 04:56:35,677 THEN EARLY CAREER AND FINALLY TO 6315 04:56:35,744 --> 04:56:41,016 INDEPENDENT POSITION. 6316 04:56:41,083 --> 04:56:43,652 AND THERE'S MECHANISMS NIH USES 6317 04:56:43,719 --> 04:56:47,523 TO SUPPORT TRAIN JAEES AND A NUR 6318 04:56:47,589 --> 04:56:49,558 OF MECHANISMS THROUGH INCLUDE AS 6319 04:56:49,625 --> 04:56:49,825 WELL. 6320 04:56:49,892 --> 04:56:54,129 I WANTED TO SAY IF THERE'S A 6321 04:56:54,196 --> 04:56:55,564 MECHANISM THAT INCLUDE DOES NOT 6322 04:56:55,631 --> 04:56:59,701 OR HAVE YOU CAN STILL APPLY TO 6323 04:56:59,768 --> 04:57:01,670 ANY NIH PARENT FUNDING 6324 04:57:01,737 --> 04:57:03,505 OPPORTUNITIES AND IF IT HAS A 6325 04:57:03,572 --> 04:57:05,174 DOWN SYNDROME FOCUS, THERE MAY 6326 04:57:05,240 --> 04:57:07,676 BE OPPORTUNITIES TO BE FUNDED 6327 04:57:07,743 --> 04:57:17,452 THROUGH INCLUDE. 6328 04:57:17,519 --> 04:57:20,189 AND LEAD TO A GRADUATE AND 6329 04:57:20,255 --> 04:57:22,591 DOCTORAL PROGRAM AND R 6330 04:57:22,658 --> 04:57:25,027 MECHANISMS AND FELLOWSHIP 6331 04:57:25,093 --> 04:57:25,961 MECHANISMS TO SUPPORT THAT 6332 04:57:26,028 --> 04:57:30,332 CAREER STAGE. 6333 04:57:30,399 --> 04:57:35,370 THERE'S TRANSITION AWARDS AND 6334 04:57:35,437 --> 04:57:38,106 THERE'S OTHER MECHANISMS SUCH AS 6335 04:57:38,173 --> 04:57:42,477 YOUR KO1s YOU HEARD DR. DERRICK 6336 04:57:42,544 --> 04:57:46,081 TALK BAND D43 AND QUESTION IN 6337 04:57:46,148 --> 04:57:48,183 THE EARLIER SESSION ABOUT 6338 04:57:48,250 --> 04:57:50,919 TRAINEES AND LOW AND MIDDLE 6339 04:57:50,986 --> 04:57:51,453 INCOME COUNTRY. 6340 04:57:51,520 --> 04:57:53,622 WE HAVE A FEW MECHANISMS TO 6341 04:57:53,689 --> 04:57:57,259 SUPPORT THOSE AS WELL. 6342 04:57:57,326 --> 04:58:02,698 AND THE EARLY CAREER MECHANISM 6343 04:58:02,764 --> 04:58:09,371 SUCH AS THE K22s AND R25 AND OF 6344 04:58:09,438 --> 04:58:18,747 COURSE YOU TRANSITION TO AN UP 6345 04:58:18,814 --> 04:58:19,214 INDEPENDENT POSITION. 6346 04:58:19,281 --> 04:58:21,883 AND YOU HEARD ABOUT THE 6347 04:58:21,950 --> 04:58:23,452 DIVERSITY SUPPLEMENTS. 6348 04:58:23,518 --> 04:58:25,287 DIVERSITY SUPPLEMENTS ARE 6349 04:58:25,354 --> 04:58:27,689 ADMINISTRATIVE SUPPLEMENT REZ 6350 04:58:27,756 --> 04:58:33,528 VIEWED INTERNALLY AND USED TO 6351 04:58:33,595 --> 04:58:34,096 DIVERSIFY THE BIOMEDICAL 6352 04:58:34,162 --> 04:58:37,366 WORKFORCE AND COULD BE APPLIED 6353 04:58:37,432 --> 04:58:38,700 THROUGHOUT THE CAREER TRAJECTORY 6354 04:58:38,767 --> 04:58:41,837 AND HAS TO BE AN ACTIVE PARENT 6355 04:58:41,903 --> 04:58:45,941 AWARD FOR DIVERSITY SUPPLEMENTS. 6356 04:58:46,008 --> 04:58:49,945 SO MOST REQUIRE U.S 6357 04:58:50,012 --> 04:58:56,618 U.SU.S. EXCELLCITIZENSHIP 6358 04:58:56,685 --> 04:58:58,720 AND THERE'S SOME MECHANISM ALLOW 6359 04:58:58,787 --> 04:59:03,659 NON-U.S. CITIZENS THAT APPLY. 6360 04:59:03,725 --> 04:59:09,931 THIS IS THE R52 INCLUDE HAS R25 6361 04:59:09,998 --> 04:59:11,667 SPECIFICALLY FOCUSSED ON 6362 04:59:11,733 --> 04:59:12,501 PROVIDING CLINICAL RESEARCH 6363 04:59:12,567 --> 04:59:13,802 EXPERIENCE FOR GRADUATE AND 6364 04:59:13,869 --> 04:59:17,472 MEDICAL STUDENTS AND MEDICAL 6365 04:59:17,539 --> 04:59:19,775 RESIDENTS, POSTDOC AS EARLY 6366 04:59:19,841 --> 04:59:21,877 CAREER FACULTY TO ASHORT COURSE. 6367 04:59:21,943 --> 04:59:24,479 THIS WAS RECENTLY PUBLISHED AND 6368 04:59:24,546 --> 04:59:26,748 IN CASE THE ONE CARRIER THAT IS 6369 04:59:26,815 --> 04:59:30,419 NOT INCLUDED IS UPPER, 6370 04:59:30,485 --> 04:59:31,119 UNDERGRADUATE STUDENTS. 6371 04:59:31,186 --> 04:59:33,255 NICHD HAS AN R52. 6372 04:59:33,322 --> 04:59:35,991 AS SAID, FIT DOESN'T HAVE A 6373 04:59:36,058 --> 04:59:38,660 PARTICULAR MECHANISM, ONE OF THE 6374 04:59:38,727 --> 04:59:41,496 I.C.s MAY HAVE A PARENT OR NIH 6375 04:59:41,563 --> 04:59:42,264 MAY HAVE A PARENT THAT ONE CAN 6376 04:59:42,331 --> 04:59:45,233 APPLY TO. 6377 04:59:45,300 --> 04:59:50,038 OF COURSE NEUROSCIENCE HAS A 6378 04:59:50,105 --> 04:59:51,473 DIVERSITY FOCUSSED R25 AND HEARD 6379 04:59:51,540 --> 04:59:55,143 FROM OTHERS ABOUT THE DATA 6380 04:59:55,210 --> 04:59:59,681 SCIENCE FOR THE DS3 PROGRAM THAT 6381 04:59:59,748 --> 05:00:02,984 CONTINUE AND FOCUSSING ON 6382 05:00:03,051 --> 05:00:03,652 INCREASING DATA SCIENTISTS FOR 6383 05:00:03,719 --> 05:00:11,093 THE FIELD. 6384 05:00:11,159 --> 05:00:13,128 THE NEXT ARE INDIVIDUAL 6385 05:00:13,195 --> 05:00:16,765 FELLOWSHIPS FOR PRE-DOCS. 6386 05:00:16,832 --> 05:00:18,900 NIH HAS SEVERAL STANDING 6387 05:00:18,967 --> 05:00:20,602 PREDOCTORAL FELLOWSHIPS FOCUSSED 6388 05:00:20,669 --> 05:00:23,472 ON WHAT IS YOUR DEGREE AND WHERE 6389 05:00:23,538 --> 05:00:25,173 YOU ARE IN THE CAREER 6390 05:00:25,240 --> 05:00:25,474 TRAJECTORY. 6391 05:00:25,540 --> 05:00:29,378 THERE'S F30s AND F31 AND 6392 05:00:29,444 --> 05:00:31,279 SPECIFIC F31 DIVERSITY 6393 05:00:31,346 --> 05:00:31,847 FELLOWSHIP. 6394 05:00:31,913 --> 05:00:34,149 IF THERE'S ANY ONE TAKEAWAY OF 6395 05:00:34,216 --> 05:00:37,252 MESSAGE FROM MY PRESENTATION IS 6396 05:00:37,319 --> 05:00:39,388 THAT PLEASE CONTACT YOUR PROGRAM 6397 05:00:39,454 --> 05:00:39,654 OFFICER. 6398 05:00:39,721 --> 05:00:42,391 IF THERE'S ANY QUESTION, THEY 6399 05:00:42,457 --> 05:00:43,692 ARE AVAILABLE TO GIVE YOU -- 6400 05:00:43,759 --> 05:00:47,062 SEND YOU RESOURCES THAT YOU WILL 6401 05:00:47,129 --> 05:00:47,496 NEED. 6402 05:00:47,562 --> 05:00:49,331 SO THERE ARE A LOT OF FUNDING 6403 05:00:49,398 --> 05:00:50,932 OPPORTUNITIES YOU NEED TO HAVE 6404 05:00:50,999 --> 05:00:52,434 THE INFORMATION AND PLEASE REACH 6405 05:00:52,501 --> 05:00:56,571 OUT TO YOUR PROGRAM OFFICERS. 6406 05:00:56,638 --> 05:00:59,474 ONE OF MY FAVORITE AWARDS ARE 6407 05:00:59,541 --> 05:01:04,312 PHASED AWARDS. 6408 05:01:04,379 --> 05:01:14,856 THIS IS RELATIVELY NEW AND 6409 05:01:19,594 --> 05:01:30,038 THEY'RE CLOSE TO DISSERTATION. 6410 05:01:30,839 --> 05:01:33,975 AND THEN THEY CAN TRANSITION 6411 05:01:34,042 --> 05:01:36,812 INTO A POSTDOC CAREER, PHASE FOR 6412 05:01:36,878 --> 05:01:38,079 THREE TO FOUR YEARS OF FUNDING. 6413 05:01:38,146 --> 05:01:41,683 THEY DON'T HAVE TO IDENTIFY A 6414 05:01:41,750 --> 05:01:43,952 LAB IN THAT APPLICATION. 6415 05:01:44,019 --> 05:01:47,789 IT HAS TO BE FOCUSSED ON DOWN 6416 05:01:47,856 --> 05:01:48,623 SYNDROME. 6417 05:01:48,690 --> 05:01:54,596 IT'S A GREAT MECHANISM AND THE 6418 05:01:54,663 --> 05:01:57,299 BRAIN INITIATIVE HAS THE SAME 6419 05:01:57,365 --> 05:01:58,333 BUT FOCUSSED ON DIVERSITY. 6420 05:01:58,400 --> 05:02:01,903 INDIVIDUALS CAN APPLY THAT. 6421 05:02:01,970 --> 05:02:03,305 YOU HEARD A LITTLE BIT ABOUT THE 6422 05:02:03,371 --> 05:02:06,274 MENTORED CAREER DEVELOPMENT 6423 05:02:06,341 --> 05:02:08,743 AWARDS INCLUDE HAS A NOTICE OF 6424 05:02:08,810 --> 05:02:10,579 SPECIAL INTEREST. 6425 05:02:10,645 --> 05:02:14,683 THIS IS AN ALPHABET SOUP OF Ks. 6426 05:02:14,749 --> 05:02:17,118 DIFFERENT CAREER POINTS OF 6427 05:02:17,185 --> 05:02:19,354 SOMEONE'S CAREER AS WELL AS A 6428 05:02:19,421 --> 05:02:21,656 MENTORED PATIENT ORIENTED 6429 05:02:21,723 --> 05:02:23,792 RESEARCH CAREER THE K23. 6430 05:02:23,859 --> 05:02:27,796 THERE'S A MOSAIC K99, K00 THAT'S 6431 05:02:27,863 --> 05:02:31,666 AN INTERESTING AWARD TO PROMOTE 6432 05:02:31,733 --> 05:02:33,468 DIVERSITY. 6433 05:02:33,535 --> 05:02:34,469 AND FOR THE INTERNATIONAL 6434 05:02:34,536 --> 05:02:36,605 TRAINEES IN LOW AND MIDDLE 6435 05:02:36,671 --> 05:02:40,275 INCOME COUNTRIES THERE'S THE K43 6436 05:02:40,342 --> 05:02:43,445 WHICH IS EMERGING GLOBAL LEADER 6437 05:02:43,512 --> 05:02:46,681 AWARD AND FOCUSSED ON CAPACITY 6438 05:02:46,748 --> 05:02:48,517 BUILDING IN THE LOW AND MIDDLE 6439 05:02:48,583 --> 05:02:49,417 INCOME COUNTRIES. 6440 05:02:49,484 --> 05:02:52,654 THERE'S K01 FOCUSSED ON 6441 05:02:52,721 --> 05:02:54,122 INTERNATIONAL RESEARCH 6442 05:02:54,189 --> 05:02:55,490 SCIENTISTS DEVELOPMENT AWARD. 6443 05:02:55,557 --> 05:02:59,494 AND OF COURSE WE ARE ALSO 6444 05:02:59,561 --> 05:03:02,631 FUNDING THE NCATS CLINICAL 6445 05:03:02,697 --> 05:03:04,633 TRANSLATIONAL AWARD PROGRAM AND 6446 05:03:04,699 --> 05:03:10,038 SUPPORTING THE KL2 CAREER 6447 05:03:10,105 --> 05:03:12,007 DEVELOPMENT AND INCLUDE IS 6448 05:03:12,073 --> 05:03:14,843 FUNDING THIS AWARD TO FOSTER A 6449 05:03:14,910 --> 05:03:19,681 PATHWAY FOR INVESTIGATORS IN THE 6450 05:03:19,748 --> 05:03:22,250 DOWN SYNDROME SPACE. 6451 05:03:22,317 --> 05:03:23,685 THE LAST SLIDE FOR THAT 6452 05:03:23,752 --> 05:03:26,221 TRANSITION TO AN INDEPENDENT 6453 05:03:26,288 --> 05:03:29,758 CAREER AGAIN WE HAVE THAT PHASED 6454 05:03:29,824 --> 05:03:34,062 AWARD AND THE K99, R00 HAD FOR 6455 05:03:34,129 --> 05:03:36,598 INDEPENDENCE AND SUPPORTING THAT 6456 05:03:36,665 --> 05:03:40,035 IS ALSO THE F32s WHICH ARE 6457 05:03:40,101 --> 05:03:43,471 INDIVIDUAL SERVICE AWARD POVLT 6458 05:03:43,538 --> 05:03:43,939 DOCTORAL FELLOWSHIP. 6459 05:03:44,005 --> 05:03:48,243 -- POST-DOCTORAL AWARD 6460 05:03:48,310 --> 05:03:48,543 FELLOWSHIP. 6461 05:03:48,610 --> 05:03:52,380 THERE'S THE LOAN REPAYMENT 6462 05:03:52,447 --> 05:03:52,714 PROGRAM. 6463 05:03:52,781 --> 05:03:54,916 IT'S A FANTASTIC PROGRAM. 6464 05:03:54,983 --> 05:03:58,019 WE KNOW ONE OF THE BARRIERS OF 6465 05:03:58,086 --> 05:04:04,593 RESEARCH TO CONTINUE ARE STUDENT 6466 05:04:04,659 --> 05:04:04,793 LOANS. 6467 05:04:04,859 --> 05:04:08,897 SO HAD A ROBUST SUCCESS RATE IN 6468 05:04:08,964 --> 05:04:11,666 THE FUNDING CYCLES, 53% OF 6469 05:04:11,733 --> 05:04:13,001 APPLICANTS WERE AWARDED. 6470 05:04:13,068 --> 05:04:15,303 THIS IS RESTRICTIVE TO 6471 05:04:15,370 --> 05:04:18,540 U.S. CITIZENS. 6472 05:04:18,607 --> 05:04:23,678 SO WE HEARD FROM BOTH DOCTOR WU 6473 05:04:23,745 --> 05:04:28,249 AND GARRICK AND BEHIND EVERY 6474 05:04:28,316 --> 05:04:30,619 SUCCESSFUL TRAINEE IS A MENTOR. 6475 05:04:30,685 --> 05:04:33,054 NIH LAUNCHED THIS CHIEF OFFICER 6476 05:04:33,121 --> 05:04:34,889 OF SCIENTIFIC WORKFORCE 6477 05:04:34,956 --> 05:04:35,457 DIVERSITY OFFICE. 6478 05:04:35,523 --> 05:04:38,193 AND THROUGH THIS OFFICE THEY 6479 05:04:38,259 --> 05:04:40,729 PILOTED THIS MENTORING 6480 05:04:40,795 --> 05:04:41,029 SUPPLEMENT. 6481 05:04:41,096 --> 05:04:43,665 THIS WAS A SUPPLEMENT FOR 6482 05:04:43,732 --> 05:04:45,000 EXISTING PARENT AWARDS. 6483 05:04:45,066 --> 05:04:48,003 THE 2022 APPLICATIONS WERE VERY 6484 05:04:48,069 --> 05:04:50,405 COMPETITIVE AND WE WERE PLEASED 6485 05:04:50,472 --> 05:04:52,107 ONE OF OUR INCLUDE DOWN SYNDROME 6486 05:04:52,173 --> 05:04:52,674 INVESTIGATORS RECEIVED THIS 6487 05:04:52,741 --> 05:04:57,345 SUPPLEMENT. 6488 05:04:57,412 --> 05:05:01,483 THAT'S WHERE I WILL END. 6489 05:05:01,549 --> 05:05:05,353 I THANK THE TWO SPEAKERS AND 6490 05:05:05,420 --> 05:05:12,627 DR. GARRICK MAKING THE FLIGHT 6491 05:05:12,694 --> 05:05:13,895 AND I APPRECIATE HER MAKING IT 6492 05:05:13,962 --> 05:05:16,798 HERE TODAY. 6493 05:05:16,865 --> 05:05:18,266 WE HAVE A FANTASTIC POSTER 6494 05:05:18,333 --> 05:05:19,968 SESSION SO LET'S SUPPORT OUR 6495 05:05:20,035 --> 05:05:20,568 TRAINEES. 6496 05:05:20,635 --> 05:05:22,103 THERE WERE 68 POSTERS. 6497 05:05:22,170 --> 05:05:25,640 WE HAD A GREAT TIME REVIEWING 6498 05:05:25,707 --> 05:05:26,241 THE ABSTRACTS. 6499 05:05:26,307 --> 05:05:30,679 SO AFTER THIS YOU CAN TAKE A 6500 05:05:30,745 --> 05:05:33,348 SHORT I THINK I MADE UP SOME 6501 05:05:33,415 --> 05:05:34,916 TIME SO A LITTLE BIT BIO BREAK 6502 05:05:34,983 --> 05:05:36,618 AND THEN LET'S HEAD UPSTAIRS. 6503 05:05:36,685 --> 05:05:39,454 THE POSTER SESSIONS ARE DIVIDE 6504 05:05:39,521 --> 05:05:40,622 TO TWO SECTIONS. 6505 05:05:40,689 --> 05:05:45,827 THEY'RE UNTIL 4:00 IS GROUP A 6506 05:05:45,894 --> 05:05:48,129 AND FROM 4:00 TO 4:45 IS GROUP B 6507 05:05:48,196 --> 05:05:49,164 AND THEN 15 MINUTES TO BREAK 6508 05:05:49,230 --> 05:05:52,233 DOWN THE POSTERS. 6509 05:05:52,300 --> 05:05:54,536 THERE'S ALSO INCLUDE A DATA 6510 05:05:54,602 --> 05:05:59,607 COORDINATING CENTER DCC 6511 05:05:59,674 --> 05:06:03,078 SPONSORED HAPPY HOUR AND THAT IS 6512 05:06:03,144 --> 05:06:04,612 AT THE HYATT. 6513 05:06:04,679 --> 05:06:06,915 WHOEVER IS ATTENDING THAT, 6514 05:06:06,981 --> 05:06:08,883 PLEASE ASK FOR -- YOU MAY HAVE 6515 05:06:08,950 --> 05:06:09,517 RECEIVED INSTRUCTIONS BUT YOU 6516 05:06:09,584 --> 05:06:12,320 CAN ASK AT THE TABLE. 6517 05:06:12,387 --> 05:06:17,125 SO WE CAN TAKE A FEW QUESTIONS 6518 05:06:17,192 --> 05:06:17,759 AND THEN I'LL GO TO THE POSTER 6519 05:06:17,826 --> 05:06:17,992 SESSION. 6520 05:06:18,059 --> 05:06:28,236 THANK YOU. 6521 05:06:50,258 --> 05:06:51,126 >> HI. 6522 05:06:51,192 --> 05:06:52,827 FROM UNIVERSITY NORTH CAROLINA. 6523 05:06:52,894 --> 05:06:53,962 EXCITED TO HANG OUT WITH YOU. 6524 05:06:54,028 --> 05:06:56,531 WE HAVE A QUESTION ON 6525 05:06:56,598 --> 05:07:00,802 RESEARCHERS OR BASIC SCIENTISTS 6526 05:07:00,869 --> 05:07:01,970 CREATE THE BEST POSSIBLE DATA 6527 05:07:02,036 --> 05:07:03,805 FOR REUSE FOR ANALYTIC. 6528 05:07:03,872 --> 05:07:05,340 FROM A TRAINING PERSPECTIVE, 6529 05:07:05,406 --> 05:07:15,950 WHAT KIND OF EMBEDDING OR CROSS 6530 05:07:19,821 --> 05:07:24,626 POLINATETION -- POLINATING CAN 6531 05:07:24,692 --> 05:07:25,126 WE DO? 6532 05:07:25,193 --> 05:07:27,128 >> IT'S EARLIER IN THE TIME 6533 05:07:27,195 --> 05:07:28,563 POINT. 6534 05:07:28,630 --> 05:07:31,699 THOUGH THE INCLUDE R25 DOESN'T 6535 05:07:31,766 --> 05:07:34,502 ALLOW UPPER GRADUATE THE R25 6536 05:07:34,569 --> 05:07:39,207 DOES DO THAT. 6537 05:07:39,274 --> 05:07:43,678 AS YOU SAID WE HAVE TO TRAIN 6538 05:07:43,745 --> 05:07:46,047 EARLIER AND THE COURSE 6539 05:07:46,114 --> 05:07:47,916 DEVELOPMENTS ARE GREAT TO CREATE 6540 05:07:47,982 --> 05:07:51,152 THE BIO INFORMATICS AND DATA 6541 05:07:51,219 --> 05:07:51,719 SCIENTISTS WE NEED FOR THE 6542 05:07:51,786 --> 05:08:01,963 PIPELINE. 6543 05:08:05,700 --> 05:08:09,204 >> I HAVE A QUESTION ABOUT THE 6544 05:08:09,270 --> 05:08:12,774 K99, R00 AWARD AND I HEARD YOU 6545 05:08:12,841 --> 05:08:16,477 CAN'T DO A CLINICAL TRIAL BUT IF 6546 05:08:16,544 --> 05:08:17,645 AN IRB IS ESTABLISHED YOU CAN 6547 05:08:17,712 --> 05:08:20,915 PLAY OFF IS THAT AND I FEEL IT 6548 05:08:20,982 --> 05:08:23,251 WOULD GIVE US OPPORTUNITIES FOR 6549 05:08:23,318 --> 05:08:28,990 GOOD IMPACTFUL RESEARCH 37 -- SO 6550 05:08:29,057 --> 05:08:30,124 I WAS CURIOUS ABOUT THAT. 6551 05:08:30,191 --> 05:08:31,426 >> IF THERE'S A CLINICAL TRIAL 6552 05:08:31,492 --> 05:08:37,098 YOU CAN BE ON THE PROTOCOL. 6553 05:08:37,165 --> 05:08:39,868 I THINK IT'S CLINICAL TRIAL NOT 6554 05:08:39,934 --> 05:08:40,101 ALLOWED. 6555 05:08:40,168 --> 05:08:50,411 >> THANK YOU. 6556 05:08:53,581 --> 05:08:55,583 >> ONE QUESTION ABOUT THE 6557 05:08:55,650 --> 05:08:58,987 EDUCATIONAL OPPORTUNITIES. 6558 05:08:59,053 --> 05:09:00,855 SO IS IT POSSIBLE TO STAY IN THE 6559 05:09:00,922 --> 05:09:01,689 SAME LAB? 6560 05:09:01,756 --> 05:09:03,725 ONE OF THE AWARDS SOUNDED LIKE 6561 05:09:03,791 --> 05:09:06,961 YOU STATED THE SAME LAB AND GOT 6562 05:09:07,028 --> 05:09:14,302 AN AWARD IN THE POSTDOC WITH THE 6563 05:09:14,369 --> 05:09:20,909 SAME MENTORS. 6564 05:09:20,975 --> 05:09:23,678 >> FROM A K01 I ENDED UP 6565 05:09:23,745 --> 05:09:26,481 INCREASING MY MENTORSHIP BUT 6566 05:09:26,547 --> 05:09:29,284 SAME PEOPLE AND STRUCTURE. 6567 05:09:29,350 --> 05:09:32,153 FOR THE K99 FOR EXAMPLE, I THINK 6568 05:09:32,220 --> 05:09:33,688 THERE IS AN ASSUMPTION YOU'RE 6569 05:09:33,755 --> 05:09:36,524 GOING TO CHANGE UNIVERSITIES BUT 6570 05:09:36,591 --> 05:09:38,526 FOR THE K01 YOU'RE ALLOWED TO 6571 05:09:38,593 --> 05:09:39,661 STAY FIVE YEARS. 6572 05:09:39,727 --> 05:09:44,065 >> LET ME SKRCORRECT THAT. 6573 05:09:44,132 --> 05:09:54,676 FOR THE R00 YOU HAVE TO BE SHOW 6574 05:09:55,576 --> 05:09:58,579 INDEPENDENCE AND SHOWING YOUR 6575 05:09:58,646 --> 05:10:01,282 R00 IS INDEPENDENT OF THE 6576 05:10:01,349 --> 05:10:03,584 POSTDOC IS CRITICAL. 6577 05:10:03,651 --> 05:10:08,256 THEY CAN'T BE IN THE SAME 6578 05:10:08,323 --> 05:10:08,957 INSTITUTION. 6579 05:10:09,023 --> 05:10:11,659 >> AND MAYBE A NAIVE QUESTION 6580 05:10:11,726 --> 05:10:21,069 WAS THE CSF ACCUMULATION RELATED 6581 05:10:21,135 --> 05:10:22,770 TO HYDRO CEPHAL IS? 6582 05:10:22,837 --> 05:10:24,572 >> NO AND THEY WERE FREE OF 6583 05:10:24,639 --> 05:10:28,576 THOSE SYSTEMS OR DIAGNOSES. 6584 05:10:28,643 --> 05:10:35,817 >> SO HYDROCEPHALUS IS NOT 6585 05:10:35,883 --> 05:10:36,284 PREVALENT? 6586 05:10:36,351 --> 05:10:37,852 >> OCCURS IN THE CLINICAL 6587 05:10:37,919 --> 05:10:44,625 POPULATIONS AT HIGHER RATES. 6588 05:10:44,692 --> 05:10:46,661 >> NOTE IN OUR SAMPLES. 6589 05:10:46,728 --> 05:10:49,197 >> I LIKE THAT YOU SAID OUR 6590 05:10:49,263 --> 05:10:50,098 SAMPLES BECAUSE THAT'S BIG IN 6591 05:10:50,164 --> 05:10:50,798 OUR RESEARCH. 6592 05:10:50,865 --> 05:10:52,333 >> THERE'S BEEN GREAT TALK ABOUT 6593 05:10:52,400 --> 05:10:53,601 THE DATA THAT'S GOING TO BE 6594 05:10:53,668 --> 05:10:54,769 COMING OUT IN THE NEXT COUPLE 6595 05:10:54,836 --> 05:10:58,072 YEARS AND HOW WE'RE ALL WORKING 6596 05:10:58,139 --> 05:11:03,644 TOGETHER TO CREATE THIS DATA. 6597 05:11:03,711 --> 05:11:07,648 I HAVE A QUESTION ABOUT FUTURE 6598 05:11:07,715 --> 05:11:12,420 FUNDING WITH TONS T DATA WE CAN 6599 05:11:12,487 --> 05:11:15,256 REUSE BECAUSE RIGHT NOW IT'S 6600 05:11:15,323 --> 05:11:18,059 MAKING DATA RELEVANT ON 6601 05:11:18,126 --> 05:11:19,594 PREVIOUSLY CREATED DATA. 6602 05:11:19,660 --> 05:11:21,562 DO YOU SEE THAT SHIFT EVERYTHING 6603 05:11:21,629 --> 05:11:25,333 TIME WITH THE LARGE DATABASES? 6604 05:11:25,400 --> 05:11:27,502 >> I DO THINK WE'LL HAVE MORE 6605 05:11:27,568 --> 05:11:29,003 USE OF THE ROV 01. 6606 05:11:29,070 --> 05:11:34,475 IT'S A SMALL BUDGET RIGHT NOW 6607 05:11:34,542 --> 05:11:36,811 ABOUT 50,000. 6608 05:11:36,878 --> 05:11:42,250 >> YOU CAN'T SUPPORT MULTIPLE 6609 05:11:42,316 --> 05:11:43,651 RESEARCHERS ON IT. 6610 05:11:43,718 --> 05:11:46,220 >> WE CAN PLAN FOR THE SPECIFIC 6611 05:11:46,287 --> 05:11:46,487 YEAR. 6612 05:11:46,554 --> 05:11:49,357 WE'RE HOPING TO GET CONTINUED 6613 05:11:49,424 --> 05:11:51,659 SUPPORT FROM CONGRESS FOR 6614 05:11:51,726 --> 05:11:53,094 INCLUDE BUT TO BE HONEST, WE 6615 05:11:53,161 --> 05:11:54,662 DON'T KNOW WHAT THE NEXT FISCAL 6616 05:11:54,729 --> 05:11:56,631 YEAR LOOKS LIKE OR MAYBE A FEW 6617 05:11:56,697 --> 05:12:00,034 YEARS DOWN THE ROAD. 6618 05:12:00,101 --> 05:12:01,436 >> BUT IF IT DOES CONTINUE WILL 6619 05:12:01,502 --> 05:12:04,072 THE FOCUS STAY ON ONE LAB OR BE 6620 05:12:04,138 --> 05:12:05,706 MORE DATA RE-ANALYSIS? 6621 05:12:05,773 --> 05:12:11,646 >> AS THE LANDSCAPE SHIFTS WE 6622 05:12:11,712 --> 05:12:17,885 HAVE THIS REPERTOIRE OF 6623 05:12:17,952 --> 05:12:19,520 MECHANISMS AND THERE'S PARENT 6624 05:12:19,587 --> 05:12:21,122 MECHANISMS AND ANYONE WHO WANTS 6625 05:12:21,189 --> 05:12:23,691 TO APPLY CAN STILL APPLY TO THE 6626 05:12:23,758 --> 05:12:25,526 PARENT MECHANISMS AND IF THEY 6627 05:12:25,593 --> 05:12:27,762 HAVE DOWN SYNDROME FOCUS WE'LL 6628 05:12:27,829 --> 05:12:30,498 BE ABLE TO PICK THAT UP IF WE 6629 05:12:30,565 --> 05:12:33,301 HAVE THE FUNDING TO SUPPORT IT. 6630 05:12:33,367 --> 05:12:33,901 >> SOUNDS GREAT. 6631 05:12:33,968 --> 05:12:35,169 >> GREAT QUESTION. 6632 05:12:35,236 --> 05:12:35,470 THANK YOU. 6633 05:12:35,536 --> 05:12:37,905 >> PARDON IF I GOT MY FACTS 6634 05:12:37,972 --> 05:12:39,774 WRONG, BUT HAVE THE TRAINING 6635 05:12:39,841 --> 05:12:43,411 AWARDS IN THE ONE-YEAR JULY 1 6636 05:12:43,478 --> 05:12:45,046 SUBMISSION DATE OR MULTIPLE 6637 05:12:45,113 --> 05:12:46,981 CYCLES TO SUBMIT FOR? 6638 05:12:47,048 --> 05:12:50,485 >> THE INCLUDE F99 IS ONE 6639 05:12:50,551 --> 05:13:00,061 RECEIPT DATE PER YEAR. 6640 05:13:00,128 --> 05:13:03,931 THE K99, F00 HAS ONE A YEAR AND 6641 05:13:03,998 --> 05:13:05,766 WANT IT SEE HOW MANY WE GET AND 6642 05:13:05,833 --> 05:13:07,068 THE PARENT HAS THREE RECEIPT 6643 05:13:07,135 --> 05:13:10,571 DATES BUT THERE IS NO PARENT 6644 05:13:10,638 --> 05:13:11,005 F99. 6645 05:13:11,072 --> 05:13:13,574 THERE'S ONE THROUGH THE BRAIN 6646 05:13:13,641 --> 05:13:15,276 INITIATIVE AND OTHER I.C. NIDDK 6647 05:13:15,343 --> 05:13:17,979 HAS THEIR OWN F99. 6648 05:13:18,045 --> 05:13:20,681 SO THERE IS NO NIH PARENT -- 6649 05:13:20,748 --> 05:13:23,117 >> WOULD YOU SUGGEST FOR THE F99 6650 05:13:23,184 --> 05:13:25,052 TO PLAN TO SUBMIT TWO YEARS OUT 6651 05:13:25,119 --> 05:13:29,924 TO HAVE A SECOND CHANCE? 6652 05:13:29,991 --> 05:13:32,894 >> THE ELIGIBILITY STARTS FOR 6653 05:13:32,960 --> 05:13:35,663 LIKE YEAR THREE OF YOUR 6654 05:13:35,730 --> 05:13:36,898 GRADUATE -- THAT'S A GREAT 6655 05:13:36,964 --> 05:13:38,866 QUESTION. 6656 05:13:38,933 --> 05:13:40,168 CAN STILL COME IN IN THE FOURTH 6657 05:13:40,234 --> 05:13:40,368 YEAR. 6658 05:13:40,434 --> 05:13:42,436 YEAH. 6659 05:13:42,503 --> 05:13:52,880 >> I HAVE A FOLLOW-UP. 6660 05:13:53,514 --> 05:14:01,622 I HAVE 99K0 AND THAT CAN BE 6661 05:14:01,689 --> 05:14:05,760 WORKING ON DOWN SYNDROME WHICH 6662 05:14:05,826 --> 05:14:08,729 CASE F OR 0 -- 6663 05:14:08,796 --> 05:14:09,297 >> BOTH. 6664 05:14:09,363 --> 05:14:11,432 >> CAN THEY WORK ON THE SAME LAB 6665 05:14:11,499 --> 05:14:12,633 OR MUST CHANGE THE LAB FOR 6666 05:14:12,700 --> 05:14:16,871 POSTDOC TRAINING? 6667 05:14:16,938 --> 05:14:23,511 >> THAT'S A GOOD QUESTION. 6668 05:14:23,578 --> 05:14:26,113 I THINK THEY HAVE TO CHANGE LAB. 6669 05:14:26,180 --> 05:14:32,620 THEY DON'T HAVE TO IDENTIFY THE 6670 05:14:32,687 --> 05:14:33,788 LAB BUT TALK ABOUT THE SCIENCE 6671 05:14:33,854 --> 05:14:34,622 THEY DO. 6672 05:14:34,689 --> 05:14:37,024 >> BUT ONCE THEY GET THE AWARD 6673 05:14:37,091 --> 05:14:39,227 THEY NEED TO SELECT THE LAB -- 6674 05:14:39,293 --> 05:14:40,595 >> THEN THERE'S A TRANSITION 6675 05:14:40,661 --> 05:14:40,895 PACKAGE. 6676 05:14:40,962 --> 05:14:46,434 AS I SAID, SIMILAR TO THE K99, R 6677 05:14:46,500 --> 05:14:48,603 OO THEY HAVE TO ESTABLISH 6678 05:14:48,669 --> 05:14:51,005 THEY'RE NOT JUST THE SAME WORK 6679 05:14:51,072 --> 05:14:52,573 BUT SOMETHING DIFFERENT AND HOW 6680 05:14:52,640 --> 05:14:55,543 DOES IT IMPACT THEIR CAREER 6681 05:14:55,610 --> 05:14:57,245 TRAJECTORY AND NOT THEIR 6682 05:14:57,311 --> 05:14:57,945 INVESTIGATOR GETTING MORE PAPER 6683 05:14:58,012 --> 05:15:00,348 IN THE SAME FIELD. 6684 05:15:00,414 --> 05:15:01,916 IT'S A PHASED TRAINING AWARD. 6685 05:15:01,983 --> 05:15:05,486 IT HAS TO HAVE AN IMPACT ON 6686 05:15:05,553 --> 05:15:05,920 THEIR CAREER. 6687 05:15:05,987 --> 05:15:08,923 IF STAYING IN THE SAME LAB BUT 6688 05:15:08,990 --> 05:15:14,862 DOING MAYBE THEY ARE THE 6689 05:15:14,929 --> 05:15:16,130 RESEARCH AND AGENCDDING OR 6690 05:15:16,197 --> 05:15:23,404 COLLABORATING THE CKOMCO-MENTOR 6691 05:15:23,471 --> 05:15:26,107 MODEL ANDING THE SHOWING THE 6692 05:15:26,173 --> 05:15:29,377 NEXT FACE IS DIFFERENT FROM THE 6693 05:15:29,443 --> 05:15:31,345 GRADUATE PROJECT, THAT SHOULD 6694 05:15:31,412 --> 05:15:33,781 SUFFICE BUT FOR THE K00 THEY 6695 05:15:33,848 --> 05:15:38,753 DON'T HAVE TO IDENTIFY A LAB. 6696 05:15:38,819 --> 05:15:39,086 >> THANK YOU. 6697 05:15:39,153 --> 05:15:40,121 >> IF THERE ARE NO MORE 6698 05:15:40,187 --> 05:15:43,658 QUESTIONS -- ONE MORE LAST 6699 05:15:43,724 --> 05:15:45,726 QUESTION. 6700 05:15:45,793 --> 05:15:49,430 >> SORRY. 6701 05:15:49,497 --> 05:15:51,699 THERE'S BEEN TRAINING 6702 05:15:51,766 --> 05:15:52,033 OPPORTUNITIES. 6703 05:15:52,099 --> 05:15:54,135 DOES THE INCLUDE PROGRAM 6704 05:15:54,201 --> 05:15:57,838 CONSIDER TO SET UP SOME SPECIAL 6705 05:15:57,905 --> 05:15:59,240 MECHANISM FOR TRACKING 6706 05:15:59,307 --> 05:15:59,874 ESTABLISHED RESEARCHERS FROM 6707 05:15:59,940 --> 05:16:01,642 OTHER FIELD TO THE KWLUD? 6708 05:16:01,709 --> 05:16:02,543 -- INCLUDE. 6709 05:16:02,610 --> 05:16:03,377 >> NO. 6710 05:16:03,444 --> 05:16:04,779 WE'RE ALREADY DOING THAT. 6711 05:16:04,845 --> 05:16:08,816 A LOT OF THE R MECHANISMS 6712 05:16:08,883 --> 05:16:13,721 ESPECIALLY THE R01s, TR01s ARE 6713 05:16:13,788 --> 05:16:16,123 SET UP WITH COLLABORATIONS AND 6714 05:16:16,190 --> 05:16:17,291 ALREADY HAVE INVESTIGATORS 6715 05:16:17,358 --> 05:16:18,292 ALREADY NOT STUDYING DOWN 6716 05:16:18,359 --> 05:16:22,096 SYNDROME AND DIDN'T HAVE A FOCUS 6717 05:16:22,163 --> 05:16:27,668 BUT HAVE BEEN APPLYING FOR R01s 6718 05:16:27,735 --> 05:16:31,605 JOINTLY WITH OTHER 6719 05:16:31,672 --> 05:16:37,611 INVESTIGATORS. 6720 05:16:37,678 --> 05:16:40,114 THE INCLUDE WEBSITE HAS ALL 6721 05:16:40,181 --> 05:16:44,985 THOSE MECHANISMS BUT IF INCLUDE 6722 05:16:45,052 --> 05:16:46,120 DOESN'T HAVE THE MECHANISM 6723 05:16:46,187 --> 05:16:49,056 PEOPLE CAN APPLY IT TO R01 BUT 6724 05:16:49,123 --> 05:16:51,592 HAS TO HAVE SOME FOCUS ON DOWN 6725 05:16:51,659 --> 05:16:53,694 SYNDROME TO BE ELIGIBLE FOR 6726 05:16:53,761 --> 05:16:53,928 FUNDING. 6727 05:16:53,994 --> 05:16:54,428 THANK YOU EVERYONE. 6728 05:16:54,495 --> 05:16:57,465 I THINK WE CAN CLOSE AND LET'S 6729 05:16:57,531 SUPPORT OUR POSTERS.