1 00:00:05,874 --> 00:00:08,410 >> GOOD MORNING, EVERYONE. 2 00:00:08,410 --> 00:00:09,845 WELCOME TO OUR FIRST NIH COUNCIL 3 00:00:09,845 --> 00:00:13,215 OF COUNCILS MEETING IN 2025. 4 00:00:13,215 --> 00:00:14,349 I'LL BANG THE GAVEL. 5 00:00:14,349 --> 00:00:18,387 THIS MEETING IS NOW IN SESSION. 6 00:00:18,387 --> 00:00:21,323 I AM NICOLE KLEINSTREUER, ACTING 7 00:00:21,323 --> 00:00:22,524 DPCPSI DIRECTOR, AND IT IS A 8 00:00:22,524 --> 00:00:24,393 PLEASURE TO BE WITH YOU ALL 9 00:00:24,393 --> 00:00:26,361 TODAY AND TO MEET YOU ALL 10 00:00:26,361 --> 00:00:26,628 VIRTUALLY. 11 00:00:26,628 --> 00:00:27,796 AND I LOOK FORWARD TO MEETING 12 00:00:27,796 --> 00:00:28,997 YOU IN PERSON IN OUR NEXT 13 00:00:28,997 --> 00:00:30,299 MEETING. 14 00:00:30,299 --> 00:00:31,533 I'LL INTRODUCE MYSELF AND TELL 15 00:00:31,533 --> 00:00:34,069 YOU A LITTLE MORE ABOUT ME LATER 16 00:00:34,069 --> 00:00:34,770 THIS MORNING. 17 00:00:34,770 --> 00:00:38,507 I AM JOINED HERE BY 18 00:00:38,507 --> 00:00:39,374 DR. FRANZISKA GRIEDER, WHO 19 00:00:39,374 --> 00:00:40,475 SERVES IN THE ROLE OF THE 20 00:00:40,475 --> 00:00:41,343 EXECUTIVE SECRETARY OF THE 21 00:00:41,343 --> 00:00:43,478 COUNCIL OF COUNCILS AND DIRECTOR 22 00:00:43,478 --> 00:00:46,048 OF THE OFFICE OF RESEARCH 23 00:00:46,048 --> 00:00:47,683 INFRASTRUCTURE PROGRAMS. 24 00:00:47,683 --> 00:00:49,985 ADDITIONALLY I WOULD LIKE TO 25 00:00:49,985 --> 00:00:51,286 RECOGNIZE MY DPCPSI COLLEAGUES 26 00:00:51,286 --> 00:00:54,690 IN THE ROOM, GRACE MCCARTHY, 27 00:00:54,690 --> 00:01:00,829 HEALTH SCIENCE POLICY AN HIT OR, 28 00:01:00,829 --> 00:01:02,331 SENIOR SCIENTIFIC ADVISOR TO THE 29 00:01:02,331 --> 00:01:06,068 DPCPSI DIRECTOR, AND PROGRAM 30 00:01:06,068 --> 00:01:09,237 ANALYST AND COUNCIL OF COUNCILS 31 00:01:09,237 --> 00:01:10,005 COORDINATOR. 32 00:01:10,005 --> 00:01:10,972 I WOULD LIKE TO THANK THE 33 00:01:10,972 --> 00:01:12,307 COUNCIL MEETING PLANNING TEAM 34 00:01:12,307 --> 00:01:13,608 MEMBERS FOR ALL OF THEIR WORK IN 35 00:01:13,608 --> 00:01:14,943 SUPPORT OF ALL OF THE COUNCIL 36 00:01:14,943 --> 00:01:15,243 ACTIVITIES. 37 00:01:15,243 --> 00:01:18,413 I WOULD ALSO LIKE TO RECOGNIZE 38 00:01:18,413 --> 00:01:20,182 THE LOGISTICS CONTRACTOR FOR THE 39 00:01:20,182 --> 00:01:21,383 COUNCIL OF COUNCIL, THE 40 00:01:21,383 --> 00:01:23,885 SCIENTIFIC CONSULTING GROUP OR 41 00:01:23,885 --> 00:01:24,319 SCG. 42 00:01:24,319 --> 00:01:27,322 BEFORE WE REALLY GET GOING, LET 43 00:01:27,322 --> 00:01:29,758 ME JUST TURN IT OVER TO FRAN SI 44 00:01:29,758 --> 00:01:32,094 KA TO REMIND OF YOU A FEW 45 00:01:32,094 --> 00:01:33,495 PROCEDURES BEFORE TAKING HOL 46 00:01:33,495 --> 00:01:36,131 CALL TO ENSURE TODAY'S MEETING 47 00:01:36,131 --> 00:01:36,465 RUNS SMOOTHLY. 48 00:01:36,465 --> 00:01:36,732 >> GREAT. 49 00:01:36,732 --> 00:01:37,766 THANK YOU, NICOLE, AND GOOD 50 00:01:37,766 --> 00:01:40,736 MORNING, EVERYBODY. 51 00:01:40,736 --> 00:01:43,038 IT IS GOOD TO SEE YOU AT LEAST 52 00:01:43,038 --> 00:01:44,339 VIRTUALLY ALL TODAY AND ALSO 53 00:01:44,339 --> 00:01:46,842 LOOKING FORWARD TO THE MAY 54 00:01:46,842 --> 00:01:48,510 MEETING WHERE WE WILL ALL BE IN 55 00:01:48,510 --> 00:01:48,944 PERSON. 56 00:01:48,944 --> 00:01:50,812 WE WILL REMIND YOU OF SOME RULES 57 00:01:50,812 --> 00:01:55,517 WHICH WILL HELP TO ENSURE THAT 58 00:01:55,517 --> 00:01:56,918 ALL ARE ABLE TO CONTRIBUTE. 59 00:01:56,918 --> 00:01:59,221 WE ASK YOU TO REMAIN MUTED WHEN 60 00:01:59,221 --> 00:02:00,322 YOU'RE NOT ACTIVELY SPEAKING TO 61 00:02:00,322 --> 00:02:02,824 THE GROUP. 62 00:02:02,824 --> 00:02:04,359 IF YOU WOULD LIKE TO MAKE A 63 00:02:04,359 --> 00:02:05,794 COMMENT OR ASK A QUESTION, 64 00:02:05,794 --> 00:02:08,964 PLEASE USE THE RAISED HAND 65 00:02:08,964 --> 00:02:09,264 FEATURE. 66 00:02:09,264 --> 00:02:10,932 YOU WILL NOTICE TODAY WE'RE ON 67 00:02:10,932 --> 00:02:11,900 TEAMS, THAT'S A LITTLE NEW FOR 68 00:02:11,900 --> 00:02:13,869 ALL OF US, NOT TEAMS IN GENERAL 69 00:02:13,869 --> 00:02:14,836 BUT TEAMS IN COUNCIL. 70 00:02:14,836 --> 00:02:18,940 SO PLEASE USE YOUR RAISED HAND 71 00:02:18,940 --> 00:02:20,776 FEATURE OR ENTER A COMMENT OR 72 00:02:20,776 --> 00:02:22,077 QUESTION DIRECTLY IN THE CHAT 73 00:02:22,077 --> 00:02:22,411 BOX. 74 00:02:22,411 --> 00:02:24,045 ONE OF US WILL CALL ON YOU AND 75 00:02:24,045 --> 00:02:27,883 WE WILL USE THE RAISED HAND 76 00:02:27,883 --> 00:02:29,017 FEATURES FIRST, AND THE CHAT BOX 77 00:02:29,017 --> 00:02:29,618 SECOND. 78 00:02:29,618 --> 00:02:31,920 IF YOU HAVE TECHNICAL 79 00:02:31,920 --> 00:02:36,825 DIFFICULTIES, PLEASE CONTACT 80 00:02:36,825 --> 00:02:39,694 DANIELLE OR ALISON AND CONTACT 81 00:02:39,694 --> 00:02:41,430 INFORMATION IS DISPLAYED ON THE 82 00:02:41,430 --> 00:02:42,664 MONITOR ON THE SLIDE RIGHT NOW. 83 00:02:42,664 --> 00:02:44,833 IF YOU HAVE CHALLENGES OR 84 00:02:44,833 --> 00:02:46,134 PROBLEMS WITH ECB, THE 85 00:02:46,134 --> 00:02:47,669 ELECTRONIC COUNCIL BOOK, PLEASE 86 00:02:47,669 --> 00:02:50,739 CONTACT BATINA VIA CHAT BOX OR 87 00:02:50,739 --> 00:02:51,940 THE NUMBER DISPLAYED AS WELL ON 88 00:02:51,940 --> 00:02:56,211 THE SCREEN. 89 00:02:56,211 --> 00:02:57,846 SO WE WILL NEXT DO ROLL CALL AT 90 00:02:57,846 --> 00:02:59,381 THIS TIME. 91 00:02:59,381 --> 00:03:00,682 WE HAVE DONE THIS MANY TIMES 92 00:03:00,682 --> 00:03:01,983 BEFORE SO YOU'RE WELL AWARE OF 93 00:03:01,983 --> 00:03:04,853 HOW WE ARE DOING THIS. 94 00:03:04,853 --> 00:03:06,822 PLEASE TELL US YOUR NAME, 95 00:03:06,822 --> 00:03:07,923 INSTITUTIONAL AFFILIATION AND 96 00:03:07,923 --> 00:03:09,424 INDICATE IF YOU HAVE SERVED ON A 97 00:03:09,424 --> 00:03:11,293 COUNCIL BEFORE AND WHICH 98 00:03:11,293 --> 00:03:11,726 COUNCIL. 99 00:03:11,726 --> 00:03:14,262 I WILL CALL YOUR NAMES IN 100 00:03:14,262 --> 00:03:14,796 ALPHABETICAL ORDER. 101 00:03:14,796 --> 00:03:18,400 ONCE I CALL YOUR NAME, PLEASE 102 00:03:18,400 --> 00:03:19,401 UNMUTE YOURSELF AND THEN 103 00:03:19,401 --> 00:03:19,935 INTRODUCE YOURSELF. 104 00:03:19,935 --> 00:03:23,205 SO HERE WE GO. 105 00:03:23,205 --> 00:03:26,074 DR. KRISTIN ARDLIE, YOU ARE UP 106 00:03:26,074 --> 00:03:27,576 FIRST DR. ARDLIE. 107 00:03:27,576 --> 00:03:30,111 >> HI, I'M AT THE BROAD 108 00:03:30,111 --> 00:03:31,112 INSTITUTE AND I HAVE NOT SERVED 109 00:03:31,112 --> 00:03:33,181 ON ANY PREVIOUS COUNCILS. 110 00:03:33,181 --> 00:03:35,150 >> THANK YOU, KRISTIN. 111 00:03:35,150 --> 00:03:40,956 DR. LI LINDA CHANG. 112 00:03:40,956 --> 00:03:43,325 >> UNIVERSITY OF MARYLAND IN 113 00:03:43,325 --> 00:03:44,659 BALTIMORE. 114 00:03:44,659 --> 00:03:47,729 I PREVIOUSLY SERVED ON THE BSC 115 00:03:47,729 --> 00:03:52,300 AT NIDA AND ALSO AT THE NIDA 116 00:03:52,300 --> 00:03:52,534 COUNCIL. 117 00:03:52,534 --> 00:03:52,934 THANK YOU. 118 00:03:52,934 --> 00:03:55,136 >> THANK YOU, LINDA. 119 00:03:55,136 --> 00:03:58,273 DR. MONICA GANDHI. 120 00:03:58,273 --> 00:04:00,308 >> YES, I'M DR. MONICA GANDHI, 121 00:04:00,308 --> 00:04:02,143 PROFESSOR OF MEDICINE AT UCSF 122 00:04:02,143 --> 00:04:05,747 AND I PREVIOUSLY SERVED AT NIAID 123 00:04:05,747 --> 00:04:09,050 ADVISORY COUNCIL, INFECTIOUS 124 00:04:09,050 --> 00:04:09,551 DISEASE RESEARCHER. 125 00:04:09,551 --> 00:04:13,421 >> THANK YOU, MONICA. 126 00:04:13,421 --> 00:04:16,091 DR. RAFAEL IRIZARRY. 127 00:04:16,091 --> 00:04:17,993 >> CHAIR OF THE DEPARTMENT OF 128 00:04:17,993 --> 00:04:19,561 DATA SCIENCE AT DANA FARBER 129 00:04:19,561 --> 00:04:21,630 CANCER INSTITUTE, PROFESSOR OF 130 00:04:21,630 --> 00:04:23,732 APPLIED STATISTICS AT HARVARD 131 00:04:23,732 --> 00:04:24,232 SCHOOL OF PUBLIC HEALTH. 132 00:04:24,232 --> 00:04:27,702 I SERVED IN THE COUNCIL FOR THE 133 00:04:27,702 --> 00:04:27,903 NHGRI. 134 00:04:27,903 --> 00:04:30,272 >> THANK YOU, RAFAEL. 135 00:04:30,272 --> 00:04:33,909 DR. KEVIN JOHNSON. 136 00:04:33,909 --> 00:04:34,843 >> GOOD MORNING. 137 00:04:34,843 --> 00:04:36,945 I'M KEVIN JOHNSON. 138 00:04:36,945 --> 00:04:38,246 I'M A UNIVERSITY PROFESSOR HERE 139 00:04:38,246 --> 00:04:41,316 AT THE UNIVERSITY OF 140 00:04:41,316 --> 00:04:42,617 PENNSYLVANIA, PEDIATRICIAN, 141 00:04:42,617 --> 00:04:44,486 RESEARCHER, AND BIOMEDICAL 142 00:04:44,486 --> 00:04:46,788 INFORMATICS PERSON, AND I'VE 143 00:04:46,788 --> 00:04:48,523 PREVIOUSLY SERVED ON THE NCRR 144 00:04:48,523 --> 00:04:50,191 COUNCIL AND ON THE BOARD OF 145 00:04:50,191 --> 00:04:51,927 SCIENTIFIC COUNSELORS FOR THE 146 00:04:51,927 --> 00:04:53,795 NLM. 147 00:04:53,795 --> 00:04:55,530 >> THANK YOU, KEVIN. 148 00:04:55,530 --> 00:04:59,401 DR. KAREN JOH JOHNSTON. 149 00:04:59,401 --> 00:05:01,069 >> HI, KAREN JOHNSTON, 150 00:05:01,069 --> 00:05:02,637 UNIVERSITY OF VIRGINIA AND I 151 00:05:02,637 --> 00:05:05,473 PREVIOUSLY SERVED ON THE NINDS 152 00:05:05,473 --> 00:05:05,707 COUNCIL. 153 00:05:05,707 --> 00:05:06,541 THANK YOU. 154 00:05:06,541 --> 00:05:08,543 >> THANK YOU, KAREN. 155 00:05:08,543 --> 00:05:10,312 BARBARA KELLEY IS NOT WITH US 156 00:05:10,312 --> 00:05:10,712 TODAY. 157 00:05:10,712 --> 00:05:13,915 SHE HAS OTHER OB OBLIGATIONS. 158 00:05:13,915 --> 00:05:14,516 >> YES, I AM. 159 00:05:14,516 --> 00:05:17,719 >> OH, SO SORRY, SO SORRY! 160 00:05:17,719 --> 00:05:20,322 MY INFORMATION IS INCORRECT. 161 00:05:20,322 --> 00:05:21,122 >> IT'S GOOD. 162 00:05:21,122 --> 00:05:22,424 I'M TRAVELING, SO I'M IN AND 163 00:05:22,424 --> 00:05:22,591 OUT. 164 00:05:22,591 --> 00:05:23,858 THANK YOU. 165 00:05:23,858 --> 00:05:25,927 I'M BARBARA KE. 166 00:05:25,927 --> 00:05:27,629 LLEY, EXECUTIVE DIRECTOR OF THE 167 00:05:27,629 --> 00:05:28,196 HEARING LOSS ASSOCIATION OF 168 00:05:28,196 --> 00:05:29,864 AMERICA AND I PREVIOUSLY SERVED 169 00:05:29,864 --> 00:05:31,232 ON THE NIDCD COUNCIL. 170 00:05:31,232 --> 00:05:31,566 >> GREAT. 171 00:05:31,566 --> 00:05:32,734 THANK YOU, BARBARA AND THANK YOU 172 00:05:32,734 --> 00:05:35,236 FOR MAKING THE EFFORT. 173 00:05:35,236 --> 00:05:38,206 DR. JEAN KING. 174 00:05:38,206 --> 00:05:47,849 >DR. KING? 175 00:05:47,849 --> 00:05:52,420 >> DR. KING, PLE PLEASE UNMUTE 176 00:05:52,420 --> 00:05:53,188 YOURSELF AND GO AHEAD. 177 00:05:53,188 --> 00:05:59,527 >> CAN YOU HELP, CHRISTINE? 178 00:05:59,527 --> 00:06:00,929 >> YES, CAN YOU HEAR ME? 179 00:06:00,929 --> 00:06:02,263 I HAVE BEEN TRYING, SORRY. 180 00:06:02,263 --> 00:06:06,067 I HAVE NO IDEA WHY IT'S NOT 181 00:06:06,067 --> 00:06:12,007 WORKING. 182 00:06:12,007 --> 00:06:13,742 >> WE COULD HEAR YOU, DR. KING. 183 00:06:13,742 --> 00:06:24,119 YOU'RE ON MUTE AGAIN. 184 00:06:26,855 --> 00:06:29,057 >> JEAN, LET'S GO TO THE NEXT 185 00:06:29,057 --> 00:06:30,959 PERSON AND I'LL COME BACK TO YOU 186 00:06:30,959 --> 00:06:32,027 AT THE END. 187 00:06:32,027 --> 00:06:34,529 LET'S GO TO DR. RICHARD KRUGMAN 188 00:06:34,529 --> 00:06:35,830 NEXT. 189 00:06:35,830 --> 00:06:36,031 DICK? 190 00:06:36,031 --> 00:06:38,566 >> I'M DICK KRUGMAN, 191 00:06:38,566 --> 00:06:39,434 DISTINGUISHED PROFESSOR OF 192 00:06:39,434 --> 00:06:41,202 PEDIATRICS AT THE UNIVERSITY OF 193 00:06:41,202 --> 00:06:43,271 COLORADO SCHOOL OF MEDICINE. 194 00:06:43,271 --> 00:06:45,674 I WORK AT THE KEMP CENTER FOR 195 00:06:45,674 --> 00:06:48,743 PREVENTION OF CHILD ABUSE AND 196 00:06:48,743 --> 00:06:49,077 NEGLECT. 197 00:06:49,077 --> 00:06:52,047 I WAS ON THE NICHD COUNCIL FOR 198 00:06:52,047 --> 00:06:53,415 FOUR YEARS BEFORE JOINING THIS 199 00:06:53,415 --> 00:06:53,581 ONE. 200 00:06:53,581 --> 00:06:53,848 >> GREAT. 201 00:06:53,848 --> 00:06:54,849 THANK YOU, DICK. 202 00:06:54,849 --> 00:06:56,951 SORRY I WAS OVEREAGER. 203 00:06:56,951 --> 00:07:00,455 NEXT IS DR. KENT LLOYD. 204 00:07:00,455 --> 00:07:01,523 >> GOOD MORNING, EVERYONE. 205 00:07:01,523 --> 00:07:02,724 MY NAME IS KENT LLOYD. 206 00:07:02,724 --> 00:07:04,125 I'M A PROFESSOR IN THE 207 00:07:04,125 --> 00:07:06,061 DEPARTMENT OF SURGERY, ASSOCIATE 208 00:07:06,061 --> 00:07:11,533 DIRECTOR OF COMPREHENSIVE CAN CR 209 00:07:11,533 --> 00:07:12,333 CENTER UNIVERSITY OF CALIFORNIA 210 00:07:12,333 --> 00:07:12,934 DAVIS AND I SERVED ON THIS 211 00:07:12,934 --> 00:07:13,835 COUNCIL OF COUNCILS PREVIOUSLY. 212 00:07:13,835 --> 00:07:14,135 THANK YOU. 213 00:07:14,135 --> 00:07:17,472 >> THANK YOU, KEN. 214 00:07:17,472 --> 00:07:22,410 DR. JENNIFER MANLY. 215 00:07:22,410 --> 00:07:31,853 JENNIFER? 216 00:07:31,853 --> 00:07:34,222 >> DR. MANLY, PLEASE UNMUTE 217 00:07:34,222 --> 00:07:43,732 YOURSELF AND GO AHEAD. 218 00:07:43,732 --> 00:07:49,537 DR. MANL YI,Y, I SEE YOU'RE UNM. 219 00:07:49,537 --> 00:07:53,374 MEELET US KNOW IF YOU ARE HAVING 220 00:07:53,374 --> 00:07:54,476 ISSUES AND WE'LL DO OUR BEST TO 221 00:07:54,476 --> 00:07:58,847 ASSIST. 222 00:07:58,847 --> 00:08:00,815 >> LET'S MOVE OND. 223 00:08:00,815 --> 00:08:05,186 NEXT IS DR. RHONDA 224 00:08:05,186 --> 00:08:06,855 ROBINSON-BEALE. 225 00:08:06,855 --> 00:08:09,023 >> GOOD MORNING. 226 00:08:09,023 --> 00:08:10,525 RHONDA ROBINSON-BEALE, 227 00:08:10,525 --> 00:08:12,927 PSYCHIATRIST BY BACKGROUND, AND 228 00:08:12,927 --> 00:08:15,130 I AM AN SVP AND CHIEF MEDICAL 229 00:08:15,130 --> 00:08:16,097 OFFICER FOR MENTAL HEALTH 230 00:08:16,097 --> 00:08:18,099 SERVICES FOR UNITED HEALTH 231 00:08:18,099 --> 00:08:18,967 GROUP. 232 00:08:18,967 --> 00:08:23,438 I SERVED PRIOR TO THIS COUNCIL 233 00:08:23,438 --> 00:08:25,006 WITH THE NATIONAL ADVISORY 234 00:08:25,006 --> 00:08:26,841 MENTAL HEALTH COUNCIL FOR SIX 235 00:08:26,841 --> 00:08:28,510 YEARS. 236 00:08:28,510 --> 00:08:31,312 >> THANK YOU, RHONDA. 237 00:08:31,312 --> 00:08:36,584 DR. SUSAN SANCHEZ. 238 00:08:36,584 --> 00:08:38,219 >> GOOD MORNING, EVERYBODY. 239 00:08:38,219 --> 00:08:39,954 SUSAN SANCHEZ, PROFESSOR OF 240 00:08:39,954 --> 00:08:41,055 INFECTIOUS DISEASES AT THE 241 00:08:41,055 --> 00:08:42,090 COLLEGE OF VETERINARY MEDICINE 242 00:08:42,090 --> 00:08:43,558 AT THE UNIVERSITY OF GEORGIA AND 243 00:08:43,558 --> 00:08:45,527 I HAVE NOT SERVED ON OTHER 244 00:08:45,527 --> 00:08:46,127 COUNCIL BEFORE THIS ONE. 245 00:08:46,127 --> 00:08:46,661 THANK YOU. 246 00:08:46,661 --> 00:08:49,697 >> THANK YOU, SUSAN. 247 00:08:49,697 --> 00:08:52,066 DR. ANNA MARIA SIEGA-RIZ. 248 00:08:52,066 --> 00:08:53,201 >> YES, GOOD MORNING. 249 00:08:53,201 --> 00:08:55,069 I AM THE DEAN OF THE SCHOOL OF 250 00:08:55,069 --> 00:08:56,471 PUBLIC HEALTH AND HEALTH 251 00:08:56,471 --> 00:08:58,873 SCIENCES AT UMASS AMHURST. 252 00:08:58,873 --> 00:09:00,141 I'M PROFESSOR OF NUTRITION AND 253 00:09:00,141 --> 00:09:01,743 IN THE DEPARTMENT OF 254 00:09:01,743 --> 00:09:03,478 EPIDEMIOLOGY AND BIOSTATISTICS. 255 00:09:03,478 --> 00:09:07,415 I HAVE PREVIOUSLY SERVED ON 256 00:09:07,415 --> 00:09:08,883 NHLBI'S ADVISORY COUNCIL. 257 00:09:08,883 --> 00:09:11,653 >> THANK YOU, ANNA MARIA. 258 00:09:11,653 --> 00:09:13,655 I UNDERSTAND LAUREN SILVIS IS 259 00:09:13,655 --> 00:09:14,522 NOT ON, CORRECT? 260 00:09:14,522 --> 00:09:15,390 YES. 261 00:09:15,390 --> 00:09:17,258 AND THEN THE LAST ONE ON THE 262 00:09:17,258 --> 00:09:20,228 LIST, SORRY, RUSS, DR. RUSS VAN 263 00:09:20,228 --> 00:09:20,461 GELDER. 264 00:09:20,461 --> 00:09:22,163 >> HI, RUSS VAN GELDER, 265 00:09:22,163 --> 00:09:23,398 PROFESSOR AND CHAIR OF 266 00:09:23,398 --> 00:09:24,566 OPHTHALMOLOGY AT UNIVERSITY OF 267 00:09:24,566 --> 00:09:25,567 WASHINGTON IN SEATTLE. 268 00:09:25,567 --> 00:09:27,268 I'VE PREVIOUSLY SERVED ON THE 269 00:09:27,268 --> 00:09:28,570 COUNCIL OF THE NATIONAL EYE 270 00:09:28,570 --> 00:09:28,903 INSTITUTE. 271 00:09:28,903 --> 00:09:30,605 >> THANK YOU, RUSS. 272 00:09:30,605 --> 00:09:32,774 LET'S TRY AGAIN, DR. JEAN KING. 273 00:09:32,774 --> 00:09:34,108 JEAN, CAN YOU HEAR US AND CAN 274 00:09:34,108 --> 00:09:34,309 YOU -- 275 00:09:34,309 --> 00:09:35,410 >> I CAN. 276 00:09:35,410 --> 00:09:36,578 >> EXCELLENT. 277 00:09:36,578 --> 00:09:38,046 >> YES, FOR SOME REASON MY 278 00:09:38,046 --> 00:09:40,481 COMPUTER WAS NOT ALLOWING ME TO 279 00:09:40,481 --> 00:09:41,115 UNMUTE MYSELF. 280 00:09:41,115 --> 00:09:43,618 MY NAME IS JEAN KING, I'M THE 281 00:09:43,618 --> 00:09:45,086 PETERSON FAMILY DEAN OF ARTS AND 282 00:09:45,086 --> 00:09:47,555 SCIENCES AT WORCESTER 283 00:09:47,555 --> 00:09:50,625 POLYTECHNIC INSTITUTE, AFFILIATE 284 00:09:50,625 --> 00:09:53,795 FACULTY IN PSYCHIATRY AT UMASS 285 00:09:53,795 --> 00:09:54,762 MEDICAL SCHOOL ALSO IN 286 00:09:54,762 --> 00:09:55,330 WORCESTER, MASS. 287 00:09:55,330 --> 00:09:58,066 AND I SERVED PREVIOUSLY ON NCCIH 288 00:09:58,066 --> 00:09:58,299 COUNCIL. 289 00:09:58,299 --> 00:10:00,335 >> WONDERFUL, THANK YOU. 290 00:10:00,335 --> 00:10:01,569 JEAN, I'M GLAD IT WORKED OUT. 291 00:10:01,569 --> 00:10:04,172 SO LET'S GIVE DR. JENNIFER MANLY 292 00:10:04,172 --> 00:10:04,939 ANOTHER TRY. 293 00:10:04,939 --> 00:10:14,349 JENNIFER? 294 00:10:14,349 --> 00:10:16,985 MAYBE WE'LL TRY ANOTHER TIME, 295 00:10:16,985 --> 00:10:17,952 JENNIFER, AND WE ARE GLAD YOU 296 00:10:17,952 --> 00:10:19,821 ARE HERE AND WE HOPE YOU CAN 297 00:10:19,821 --> 00:10:22,357 HEAR US AND THEN HOPEFULLY YOU 298 00:10:22,357 --> 00:10:24,859 CAN CONTRIBUTE IN SOME WAY. 299 00:10:24,859 --> 00:10:27,262 WITH THAT, LET ME MOVE ON TO A 300 00:10:27,262 --> 00:10:28,730 FEW MORE ANNOUNCEMENTS THAT I 301 00:10:28,730 --> 00:10:34,702 HAVE TO MAKE TO GET US GOING. 302 00:10:34,702 --> 00:10:35,837 MEETING MATERIALS WERE SENT TO 303 00:10:35,837 --> 00:10:39,274 YOU FOR THIS MEETING ON 304 00:10:39,274 --> 00:10:40,041 APRIL 16TH. 305 00:10:40,041 --> 00:10:43,978 YOU RECEIVED THOSE MATERIALS VIA 306 00:10:43,978 --> 00:10:44,445 EMAIL. 307 00:10:44,445 --> 00:10:48,149 AS MEMBERS OF THIS COUNCIL, YOU 308 00:10:48,149 --> 00:10:50,785 ARE SPECIAL GOVERNMENT 309 00:10:50,785 --> 00:10:51,719 EMPLOYEES, AND, THEREFORE, 310 00:10:51,719 --> 00:10:52,987 SUBJECT TO THE RULES OF CONDUCT 311 00:10:52,987 --> 00:10:54,489 THAT APPLY TO ALL FEDERAL 312 00:10:54,489 --> 00:10:56,557 EMPLOYEES. 313 00:10:56,557 --> 00:10:59,527 THESE RULES AND REGULATIONS ARE 314 00:10:59,527 --> 00:11:04,232 EXPLAINED IN A REPORT WHICH IS 315 00:11:04,232 --> 00:11:05,333 ENTITLED STANDARDS OF ETHICAL 316 00:11:05,333 --> 00:11:07,201 CONDUCT FOR EMPLOYEES OF THE 317 00:11:07,201 --> 00:11:08,069 EXECUTIVE BRANCH AND YOU 318 00:11:08,069 --> 00:11:10,004 RECEIVED THAT REPORT WHEN YOU 319 00:11:10,004 --> 00:11:10,905 WERE FIRST APPOINTED TO THIS 320 00:11:10,905 --> 00:11:13,741 COUNCIL. 321 00:11:13,741 --> 00:11:15,610 AT EVERY MEETING IN ADDITION TO 322 00:11:15,610 --> 00:11:16,277 REMINDING YOU ABOUT THE 323 00:11:16,277 --> 00:11:18,212 IMPORTANCE OF FOLLOWING THE 324 00:11:18,212 --> 00:11:19,981 ETHICS RULES, WE ALWAYS LIKE TO 325 00:11:19,981 --> 00:11:21,516 REVIEW THE STEPS THAT WE TAKE 326 00:11:21,516 --> 00:11:24,886 AND ASK YOU TO TAKE TO ENSURE 327 00:11:24,886 --> 00:11:27,956 THAT ANY CONFLICT OF TRL TBEEN 328 00:11:27,956 --> 00:11:30,692 YOUR PUBLIC RESPONSIBILITIES AND 329 00:11:30,692 --> 00:11:33,528 YOUR PRIVATE INTERESTS ARE 330 00:11:33,528 --> 00:11:36,497 IDENTIFIED AND ADDRESSED. 331 00:11:36,497 --> 00:11:37,498 THREE TIMES A YEAR, YOU PROVIDE 332 00:11:37,498 --> 00:11:40,201 US WITH INFORMATION ABOUT YOUR 333 00:11:40,201 --> 00:11:41,636 PERSONAL, PROFESSIONAL, AND 334 00:11:41,636 --> 00:11:42,937 FINANCIAL INTERESTS. 335 00:11:42,937 --> 00:11:45,473 WE USE THIS INFORMATION AS THE 336 00:11:45,473 --> 00:11:49,043 BASIS FOR ASSESSING WHETHER YOU 337 00:11:49,043 --> 00:11:51,245 HAVE ANY REAL, POTENTIAL OR 338 00:11:51,245 --> 00:11:54,649 APPARENT CONFLICT OF INTEREST. 339 00:11:54,649 --> 00:11:55,650 THAT COULD COMPROMISE YOUR 340 00:11:55,650 --> 00:11:57,952 ABILITY TO BE OBJECTIVE IN 341 00:11:57,952 --> 00:12:00,822 GIVING ADVICE DURING COUNCIL 342 00:12:00,822 --> 00:12:01,222 MEETINGS. 343 00:12:01,222 --> 00:12:02,523 IF SUCH CONFLICTS ARE 344 00:12:02,523 --> 00:12:03,825 IDENTIFIED, WE EITHER ISSUE A 345 00:12:03,825 --> 00:12:06,461 WAIVER OR RECUSE YOU FROM A 346 00:12:06,461 --> 00:12:07,996 PORTION OF THE MEETING. 347 00:12:07,996 --> 00:12:12,266 WE ALSO RELY TO A GREAT DEGREE 348 00:12:12,266 --> 00:12:13,468 ON YOU TO BE ATTENTIVE DURING 349 00:12:13,468 --> 00:12:15,370 OUR MEETING TO THE POSSIBILITY 350 00:12:15,370 --> 00:12:18,806 THAT IF AN ISSUE ARISES THAT 351 00:12:18,806 --> 00:12:21,342 COULD AFFECT OR APPEAR TO AFFECT 352 00:12:21,342 --> 00:12:23,678 YOUR INTERESTS IN A SPECIFIC 353 00:12:23,678 --> 00:12:23,978 WAY. 354 00:12:23,978 --> 00:12:27,015 IF THAT HAPPENS, WE ASK YOU TO 355 00:12:27,015 --> 00:12:28,783 RECUSE YOURSELF FROM THE 356 00:12:28,783 --> 00:12:29,550 DISCUSSION, AND BECAUSE THIS IS 357 00:12:29,550 --> 00:12:31,386 A VIRTUAL MEETING, YOU WILL BE 358 00:12:31,386 --> 00:12:32,920 PLACED IN A WAITING ROOM AFTER 359 00:12:32,920 --> 00:12:34,689 YOU TELL US IN THE CHAT THAT 360 00:12:34,689 --> 00:12:37,291 THERE IS A CONFLICT. 361 00:12:37,291 --> 00:12:38,626 IF YOU HAVE ANY QUESTIONS ABOUT 362 00:12:38,626 --> 00:12:40,695 THE RULES OF CONDUCT OR 363 00:12:40,695 --> 00:12:42,563 CONFLICTS OF INTEREST, YOUR 364 00:12:42,563 --> 00:12:45,266 COMMITTEE OR OUR COMMITTEE 365 00:12:45,266 --> 00:12:47,035 MANAGEMENT SPECIALIST, HER NAME 366 00:12:47,035 --> 00:12:48,669 IS FAITH MACK AND YOU HAVE 367 00:12:48,669 --> 00:12:49,904 INTERACTED WITH HER MANY TIMES 368 00:12:49,904 --> 00:12:52,507 BEFORE OR I WILL BE GLAD TO 369 00:12:52,507 --> 00:12:56,544 ADDRESS YOUR CONCERNS. 370 00:12:56,544 --> 00:12:58,846 FOR TODAY'S MEETING, TIME IS 371 00:12:58,846 --> 00:13:00,715 ALLOCATED IN THE AGENDA FOR 372 00:13:00,715 --> 00:13:03,985 DISCUSSIONS BY THE COUNCIL. 373 00:13:03,985 --> 00:13:04,218 WITH 374 00:13:04,218 --> 00:13:05,520 THE COUNCIL BUT UNFORTUNATELY 375 00:13:05,520 --> 00:13:08,256 THERE'S LIMITED TIME FOR ANY 376 00:13:08,256 --> 00:13:10,458 COMMENTS FROM OTHERS FROM OTHER 377 00:13:10,458 --> 00:13:10,725 ATTENDEES. 378 00:13:10,725 --> 00:13:12,627 THE PUBLIC IS WELCOME TO SUBMIT 379 00:13:12,627 --> 00:13:15,196 COMMENTS IN WRITING AFTER THE 380 00:13:15,196 --> 00:13:16,030 MEETING. 381 00:13:16,030 --> 00:13:18,966 INSTRUCTIONS FOR DOING SO ARE IN 382 00:13:18,966 --> 00:13:19,967 THE FEDERAL REGISTER NOTICE THAT 383 00:13:19,967 --> 00:13:23,037 WAS PUBLISHED FOR THIS MEETING 384 00:13:23,037 --> 00:13:27,508 ON MARCH 25. 385 00:13:27,508 --> 00:13:28,509 APPROVED MINUTES WILL BE POSTED 386 00:13:28,509 --> 00:13:31,779 ON THE DPCPSI WEBSITE, AND WITH 387 00:13:31,779 --> 00:13:32,780 REGARD TO FUTURE MEETING DATES, 388 00:13:32,780 --> 00:13:34,182 THERE ARE THREE WAYS HOW YOU CAN 389 00:13:34,182 --> 00:13:35,283 GET THOSE DATES. 390 00:13:35,283 --> 00:13:37,485 THEY ARE ALWAYS LISTED ON YOUR 391 00:13:37,485 --> 00:13:39,220 AGENDA, THEY ARE ALWAYS LISTED 392 00:13:39,220 --> 00:13:40,788 ON THE DPCPSI WEBSITE AND OF 393 00:13:40,788 --> 00:13:42,156 COURSE YOU CAN ALWAYS EMAIL ME 394 00:13:42,156 --> 00:13:45,993 AND I WILL TELL YOU WITH A 395 00:13:45,993 --> 00:13:46,861 REMINDER. 396 00:13:46,861 --> 00:13:48,830 LET ME REMIND YOU AGAIN OF THE 397 00:13:48,830 --> 00:13:49,831 MICROPHONES. 398 00:13:49,831 --> 00:13:51,466 NICOLE TOLD YOU, I TOLD YOU, THE 399 00:13:51,466 --> 00:13:52,333 MEETING IS BEING RECORDED AND 400 00:13:52,333 --> 00:13:53,534 WILL BE TRANSCRIBED. 401 00:13:53,534 --> 00:13:55,303 PLEASE UNMUTE YOURSELF WHEN YOU 402 00:13:55,303 --> 00:13:57,605 SPEAK AND IDENTIFY YOURSELF. 403 00:13:57,605 --> 00:13:59,574 ALSO PLEASE MUTE YOURSELF AFTER 404 00:13:59,574 --> 00:14:01,709 YOU HAVE FINISHED SO OTHERS CAN 405 00:14:01,709 --> 00:14:03,945 TURN THEIR MICROPHONES ON. 406 00:14:03,945 --> 00:14:06,347 PLEASE NOTE THAT THE HOST OF THE 407 00:14:06,347 --> 00:14:09,283 MEETING CAN CONTROL YO YOUR 408 00:14:09,283 --> 00:14:10,818 MICROPHONE AS WELL IN CASE YOU 409 00:14:10,818 --> 00:14:12,253 HAVE FORGOTTEN TO TURN YOURSELF 410 00:14:12,253 --> 00:14:14,856 OFF. 411 00:14:14,856 --> 00:14:16,457 AND REMINDER TO TURN ON YOUR 412 00:14:16,457 --> 00:14:17,825 VIDEOS AND CAMERAS IF YOU ARE 413 00:14:17,825 --> 00:14:18,726 SPEAKING. 414 00:14:18,726 --> 00:14:21,762 IF YOU NEED ANY ASSISTANCE, THE 415 00:14:21,762 --> 00:14:23,831 CHAT FUNCTION IS A GOOD WAY TO 416 00:14:23,831 --> 00:14:27,802 GET ASSISTANCE. 417 00:14:27,802 --> 00:14:28,870 DON'T MAYBE SEND REQUESTS TO 418 00:14:28,870 --> 00:14:29,971 EVERYBODY, YOU ALWAYS CAN 419 00:14:29,971 --> 00:14:32,039 ADDRESS VERY SPECIFIC PEOPLE. 420 00:14:32,039 --> 00:14:34,208 SO FINALLY, CLOSED SESSION WILL 421 00:14:34,208 --> 00:14:37,712 BE HELD FROM 12:15 TO 422 00:14:37,712 --> 00:14:40,014 1:00 TODAY. 423 00:14:40,014 --> 00:14:41,983 IN ATTENDANCE -- IN ACCORDANCE 424 00:14:41,983 --> 00:14:43,851 WITH NIH AND FEDERAL POLICY, 425 00:14:43,851 --> 00:14:46,587 ATTENDANCE IS RESTRICTED TO 426 00:14:46,587 --> 00:14:49,323 COUNCILMEMBERS AND RELEVANT NIH 427 00:14:49,323 --> 00:14:49,657 STAFF. 428 00:14:49,657 --> 00:14:50,625 FOLLOWING THE CLOSED SESSION, WE 429 00:14:50,625 --> 00:14:53,361 HAVE A BRIEF BREAK FOR LUNCH AND 430 00:14:53,361 --> 00:14:56,864 WE WILL RESUME THE OPEN SESSION 431 00:14:56,864 --> 00:15:02,236 AT 1:15. 432 00:15:02,236 --> 00:15:05,273 ARE THERE ANY QUESTIONS AT THIS 433 00:15:05,273 --> 00:15:06,507 TIME? 434 00:15:06,507 --> 00:15:08,075 I'M NOT SEEING ANY QUESTIONS, 435 00:15:08,075 --> 00:15:08,943 THEREFORE, I'LL TURN THE 436 00:15:08,943 --> 00:15:12,280 MICROPHONE BASS OVER TO YOU. 437 00:15:12,280 --> 00:15:17,318 >> THANK YOU, FRAN CHESS THAT. 438 00:15:17,318 --> 00:15:17,652 FRANZISKA. 439 00:15:17,652 --> 00:15:19,187 I WOULD LIKE TO REPEAT THAT WE 440 00:15:19,187 --> 00:15:20,488 ARE IN OPEN SESSION OF TODAY'S 441 00:15:20,488 --> 00:15:21,923 MEETING WHICH MEANS OPEN TO THE 442 00:15:21,923 --> 00:15:23,391 PUBLIC, INCLUDING MEMBERS OF THE 443 00:15:23,391 --> 00:15:23,658 PRESS. 444 00:15:23,658 --> 00:15:24,892 WE ARE VIDEOCASTING THIS MEETING 445 00:15:24,892 --> 00:15:26,194 SO ALL INTERESTED PARTIES CAN 446 00:15:26,194 --> 00:15:27,395 LISTEN. 447 00:15:27,395 --> 00:15:28,496 ALL RIGHT. 448 00:15:28,496 --> 00:15:29,564 LET'S KICK THINGS OFF. 449 00:15:29,564 --> 00:15:33,301 WE HAVE A VERY PACKED AGENDA, 450 00:15:33,301 --> 00:15:34,168 CERTAINLY IF YOU NEED TO STEP 451 00:15:34,168 --> 00:15:35,469 AWAY FOR A MINUTE, WE DO 452 00:15:35,469 --> 00:15:37,338 UNDERSTAND. 453 00:15:37,338 --> 00:15:42,143 SO AFTER I PROVIDE SOME DPCPSI 454 00:15:42,143 --> 00:15:44,979 UPDATES, OUR AGENDA WILL INCLUDE 455 00:15:44,979 --> 00:15:47,415 REMARKS FROM THE NIH DIRECTOR, 456 00:15:47,415 --> 00:15:49,050 DR. BHATTACHARYA, FOR CONCEPT 457 00:15:49,050 --> 00:15:51,452 CLEARANCES, NOT IN THAT ORDER 458 00:15:51,452 --> 00:15:52,653 ACTUALLY, FIRST SOME CONCEPT 459 00:15:52,653 --> 00:15:53,754 CLEARANCE, THEN LATER IN THE DAY 460 00:15:53,754 --> 00:15:55,389 REMARKS FROM OUR NEW NIH 461 00:15:55,389 --> 00:15:55,890 DIRECTOR. 462 00:15:55,890 --> 00:15:58,326 WE WILL ALSO HAVE A PRESENTATION 463 00:15:58,326 --> 00:15:59,527 ON A COUNCIL OF COUNCIL WORK 464 00:15:59,527 --> 00:16:01,829 GROUP ON SCIENCE OF SCIENCE, AND 465 00:16:01,829 --> 00:16:04,565 WE WILL CLOSE OUT THE DAY WITH 466 00:16:04,565 --> 00:16:06,767 REFLECTIONS FROM OUR DEPARTING 467 00:16:06,767 --> 00:16:09,270 COUNCILMEMBERS. 468 00:16:09,270 --> 00:16:11,472 SO AS YOU KNOW, THE DIRECTORS OF 469 00:16:11,472 --> 00:16:13,207 EACH OF THE DPCPSI PROGRAM 470 00:16:13,207 --> 00:16:15,109 OFFICES SERVE AS NON-VOTING 471 00:16:15,109 --> 00:16:16,711 LIAISONS TO THE COUNCIL. 472 00:16:16,711 --> 00:16:18,579 THEY ARE LISTED HERE WITH THEIR 473 00:16:18,579 --> 00:16:20,548 PHOTOS ON THIS SLIDE, AND THEY 474 00:16:20,548 --> 00:16:21,983 ARE ALSO ON THE CALL AND 475 00:16:21,983 --> 00:16:23,651 AVAILABLE FOR INPUTS OR COMMENTS 476 00:16:23,651 --> 00:16:25,152 IF NEEDED. 477 00:16:25,152 --> 00:16:28,723 I WANT TO TAKE A MOMENT TO NOTE 478 00:16:28,723 --> 00:16:33,661 THAT STEFFAN PASIOKAS LEFT FOR 479 00:16:33,661 --> 00:16:35,529 AN OPPORTUNITY TO ACADEMIA AND 480 00:16:35,529 --> 00:16:37,632 DREW BREMER, DIRECTOR OF THE 481 00:16:37,632 --> 00:16:39,133 OFFICE OF NUTRITION RESEARCH HAS 482 00:16:39,133 --> 00:16:40,434 KINDLY AGREED TO TEMPORARILY 483 00:16:40,434 --> 00:16:42,536 SERVE AS THE ACTING DIRECTOR OF 484 00:16:42,536 --> 00:16:44,071 ODS. 485 00:16:44,071 --> 00:16:45,806 ALSO IN ALIGNMENT WITH THE 486 00:16:45,806 --> 00:16:46,741 ADMINISTRATION'S EXECUTIVE ORDER 487 00:16:46,741 --> 00:16:49,210 ON DEFENDING WOMEN FROM GENDER 488 00:16:49,210 --> 00:16:50,945 ETIOLOGY EXTREMISM AND RESTORING 489 00:16:50,945 --> 00:16:52,113 BIOLOGICAL TRUTH TO THE FEDERAL 490 00:16:52,113 --> 00:16:53,147 GOVERNMENT, NIH IS TERMINATING 491 00:16:53,147 --> 00:16:54,782 GROUPS THAT DO NOT ALIGN WITH 492 00:16:54,782 --> 00:16:55,316 THAT E.O. 493 00:16:55,316 --> 00:16:57,618 THIS INCLUDES THE SEXUAL AND 494 00:16:57,618 --> 00:16:59,053 GENDER MINORITY RESEARCH OFFICE 495 00:16:59,053 --> 00:17:01,555 IN DPCPSI AND THE COUNCIL OF 496 00:17:01,555 --> 00:17:02,990 COUNCIL'S SEXUAL AND GENDER 497 00:17:02,990 --> 00:17:03,991 MINORITY RESEARCH WORKING GROUP. 498 00:17:03,991 --> 00:17:05,293 WE WILL NOTIFY THE WORKING GROUP 499 00:17:05,293 --> 00:17:06,827 MEMBERS FOLLOWING THIS MEETING 500 00:17:06,827 --> 00:17:08,629 OF THE DISSOLUTION OF THE 501 00:17:08,629 --> 00:17:09,330 WORKING GROUP. 502 00:17:09,330 --> 00:17:13,034 SO NOW TO TURN TO THE DPCPSI 503 00:17:13,034 --> 00:17:17,204 UPDATES, SO I WANT TO START BY 504 00:17:17,204 --> 00:17:18,506 ANNOUNCING SOME EXCITING 505 00:17:18,506 --> 00:17:25,079 ADDITIONS TO DPCPSI. 506 00:17:25,079 --> 00:17:27,682 FIRST MYSELF ALTHOUGH THAT'S 507 00:17:27,682 --> 00:17:29,850 LESS EXCITING THAN THE NEXT 508 00:17:29,850 --> 00:17:31,752 SLIDE BUT JUST TO SAY HELLO AND 509 00:17:31,752 --> 00:17:33,487 INTRODUCE MYSELF TO ALL OF YOU. 510 00:17:33,487 --> 00:17:36,023 I WAS PRIVILEGED TO BE APPOINTED 511 00:17:36,023 --> 00:17:37,658 THE ACTING NIH DEPUTY DIRECTOR 512 00:17:37,658 --> 00:17:38,859 FOR PROGRAM COORDINATION 513 00:17:38,859 --> 00:17:40,261 PLANNING AND STRATEGIC 514 00:17:40,261 --> 00:17:42,463 INITIATIVES ON APRIL 10TH, SO 515 00:17:42,463 --> 00:17:44,665 JUST UNDER TWO WEEKS AGO. 516 00:17:44,665 --> 00:17:46,534 THAT OF COURSE MEANS THAT I AM 517 00:17:46,534 --> 00:17:47,935 ALSO DIRECTING THE DIVISION FOR 518 00:17:47,935 --> 00:17:48,936 PROGRAM COORDINATION PLANNING 519 00:17:48,936 --> 00:17:51,305 AND STRATEGIC INITIATIVES. 520 00:17:51,305 --> 00:17:55,042 I HAVE BEEN A PART OF NIH FOR 521 00:17:55,042 --> 00:17:55,710 ALMOST 10 YEARS. 522 00:17:55,710 --> 00:17:58,813 I CAME FROM NIEHS, NATIONAL 523 00:17:58,813 --> 00:17:59,747 INSTITUTE FOR ENVIRONMENTAL 524 00:17:59,747 --> 00:18:02,783 HEALTH SCIENCES, THE DIVISION OF 525 00:18:02,783 --> 00:18:03,351 TRANSLATIONAL TOXICOLOGY. 526 00:18:03,351 --> 00:18:05,886 I WAS DIRECTOR OF THE NTP 527 00:18:05,886 --> 00:18:06,520 INTERAGENCY CENTER FOR THE 528 00:18:06,520 --> 00:18:08,589 EVALUATION OF ALTERNATIVE 529 00:18:08,589 --> 00:18:11,359 TOXICOLOGICAL METHODS OR 530 00:18:11,359 --> 00:18:13,094 NICEATM, ALSO DIRECTLY DIRECTOR 531 00:18:13,094 --> 00:18:14,495 OF THE CONGRESSIONAL MANDATED 532 00:18:14,495 --> 00:18:15,563 INTERAGENCY COORDINATING 533 00:18:15,563 --> 00:18:16,697 COMMITTEE FOR THE VALIDATION OF 534 00:18:16,697 --> 00:18:17,798 ALTERNATIVE METHODS WHICH COP 535 00:18:17,798 --> 00:18:21,836 CYCONSISTS OF 18 DIFFERENT FEDEL 536 00:18:21,836 --> 00:18:23,037 AGENCIES INCLUDING NIH AND 537 00:18:23,037 --> 00:18:24,472 SEVERAL INSTITUTES AND CENTERS 538 00:18:24,472 --> 00:18:26,640 WITHIN NIH, AND THERE I WAS 539 00:18:26,640 --> 00:18:29,510 REALLY, REALLY HONORED TO BE 540 00:18:29,510 --> 00:18:31,045 LEADING INTERAGENCY AND 541 00:18:31,045 --> 00:18:33,781 INTERNATIONAL EFFORTS TO DEVELOP 542 00:18:33,781 --> 00:18:35,416 AND VALIDATE WHAT ARE CALLED 543 00:18:35,416 --> 00:18:36,517 NAMs, I'M SURE ALL OF YOU ARE 544 00:18:36,517 --> 00:18:37,685 FAMILIAR WITH THAT TERM, BUT 545 00:18:37,685 --> 00:18:39,553 THEY'RE A NEW APPROACH 546 00:18:39,553 --> 00:18:40,321 METHODOLOGIES. 547 00:18:40,321 --> 00:18:42,189 MY PERSONAL BACKGROUND IS 548 00:18:42,189 --> 00:18:43,824 ACTUALLY IN COMPUTATIONAL 549 00:18:43,824 --> 00:18:45,126 MODELING, BIOMEDICAL 550 00:18:45,126 --> 00:18:46,127 ENGINEERING, ARTIFICIAL 551 00:18:46,127 --> 00:18:48,429 INTELLIGENCE AND SYSTEMS 552 00:18:48,429 --> 00:18:49,630 MODELING, AND SO I'M JUST 553 00:18:49,630 --> 00:18:51,599 REALLY, REALLY EXCITED TO BE IN 554 00:18:51,599 --> 00:18:53,033 THIS POSITION AND TO LEARN MORE 555 00:18:53,033 --> 00:18:56,070 AND MORE ABOUT DPCPSI AND THE 556 00:18:56,070 --> 00:18:57,505 OUTSTANDING WORK THAT'S BEING 557 00:18:57,505 --> 00:18:59,907 DONE ACROSS ALL OF NIH, BOTH 558 00:18:59,907 --> 00:19:01,208 WITHIN THE DPCPSI OFFICES AND 559 00:19:01,208 --> 00:19:03,744 ACROSS ALL OF THE ICs. 560 00:19:03,744 --> 00:19:04,812 OKAY. 561 00:19:04,812 --> 00:19:08,916 MOVING TO THE NECT INEQUITIES NM 562 00:19:08,916 --> 00:19:10,251 VERY PLEASED TO ANNOUNCE THE 563 00:19:10,251 --> 00:19:12,119 FORMAL ADDITION OF THE ALL-OF-US 564 00:19:12,119 --> 00:19:14,722 RESEARCH PROGRAM OFFICE, AND THE 565 00:19:14,722 --> 00:19:17,124 ECHO PROGRAM OFFICE TO DPCPSI. 566 00:19:17,124 --> 00:19:18,826 WE ALSO INTEGRATED THE 567 00:19:18,826 --> 00:19:20,861 MANAGEMENT OF THE INCLUDE 568 00:19:20,861 --> 00:19:22,563 PROJECT INTO THE DPCPSI 569 00:19:22,563 --> 00:19:23,798 DIRECTOR'S OFFICE. 570 00:19:23,798 --> 00:19:26,200 AS YOU ALL ARE PROBABLY AWARE, 571 00:19:26,200 --> 00:19:27,968 DPCPSI HAS INFORMALLY WELCOMED 572 00:19:27,968 --> 00:19:29,370 THEM INTO THE FOLD FOR THE PAST 573 00:19:29,370 --> 00:19:30,838 YEAR SO THAT PROCESS ACTUALLY 574 00:19:30,838 --> 00:19:33,541 STARTED AT THE END OF 2023, BUT 575 00:19:33,541 --> 00:19:35,409 WE'RE VERY EXCITED THAT THESE 576 00:19:35,409 --> 00:19:36,710 TRANSFORMATIVE PROGRAMS ARE NOW 577 00:19:36,710 --> 00:19:42,183 OFFICIALLY IN DPCPSI. 578 00:19:42,183 --> 00:19:44,051 ON SEPTEMBER 24TH, THE OFFICE 579 00:19:44,051 --> 00:19:46,454 AIDS RESEARCH HOSTED THE SECOND 580 00:19:46,454 --> 00:19:48,088 INNOVATION IN AIDS RESEARCH 581 00:19:48,088 --> 00:19:49,623 SYMPOSIUM HELD DURING THE NIH 582 00:19:49,623 --> 00:19:50,057 RESEARCH FESTIVAL. 583 00:19:50,057 --> 00:19:51,692 THIS WAS A HYBRID EVENT. 584 00:19:51,692 --> 00:19:53,661 IT FEATURED INTRAMURAL 585 00:19:53,661 --> 00:19:56,063 INVESTIGATORS WHO RECEIVE 586 00:19:56,063 --> 00:19:57,765 INNOVATION PROGRAM AWARDS WITH 587 00:19:57,765 --> 00:20:00,000 16 PRESENTATIONS COVERING 588 00:20:00,000 --> 00:20:01,769 ASSORTED TOPICS SUCH AS 589 00:20:01,769 --> 00:20:03,404 VIROLOGY, VACCINE DISCOVERY, 590 00:20:03,404 --> 00:20:06,807 DATA SCIENCE, COMORBIDITIES, 591 00:20:06,807 --> 00:20:08,008 COINFECTIONS. 592 00:20:08,008 --> 00:20:09,844 THIS SYMPOSIUM HIGHLIGHTED THE 593 00:20:09,844 --> 00:20:11,812 PROGRAM'S IMPACT IN FOSTERING 594 00:20:11,812 --> 00:20:12,680 INNOVATIVE RESEARCH WITH THE 595 00:20:12,680 --> 00:20:14,348 POTENTIAL TO ADVANCE THE HIV 596 00:20:14,348 --> 00:20:17,284 CARE CONTINUUM. 597 00:20:17,284 --> 00:20:18,619 PARTICIPANTS REMARKED THAT THEY 598 00:20:18,619 --> 00:20:19,920 APPRECIATED THE OPPORTUNITY FOR 599 00:20:19,920 --> 00:20:21,188 NETWORKING AND GAINING INSIGHTS 600 00:20:21,188 --> 00:20:26,060 INTO THE INTRAMURAL HIV RESEARCH 601 00:20:26,060 --> 00:20:28,996 COMMUNITY. 602 00:20:28,996 --> 00:20:31,832 IN DECEMBER OAR HAD A BUS EYE 603 00:20:31,832 --> 00:20:37,304 BUSY ANDE 604 00:20:37,304 --> 00:20:38,939 EXCITING MONTH OF WORLD AIDS 605 00:20:38,939 --> 00:20:39,807 DAY. 606 00:20:39,807 --> 00:20:41,675 OAR HOSTED A WORLD AIDS DAY 607 00:20:41,675 --> 00:20:42,109 VIRTUAL PANEL. 608 00:20:42,109 --> 00:20:45,412 THIS WAS ATTENDED BY OVER 500 609 00:20:45,412 --> 00:20:46,814 PARTICIPANTS, AND THAT'S NOTABLE 610 00:20:46,814 --> 00:20:49,316 BECAUSE IT'S A 42% INCREASE FROM 611 00:20:49,316 --> 00:20:51,519 2023. 612 00:20:51,519 --> 00:20:55,956 SEVERAL OAR STAFF ATTENDED THE 613 00:20:55,956 --> 00:20:57,558 FIRST EVER WHITE HOUSE DISPLAY 614 00:20:57,558 --> 00:21:00,728 OF THE AIDS QUILT, TWO 615 00:21:00,728 --> 00:21:01,629 CONGRESSIONAL RECEPTIONS 616 00:21:01,629 --> 00:21:03,130 HONORING THE RETIRING 617 00:21:03,130 --> 00:21:05,866 REPRESENTATIVE BARBARA LEE WHO 618 00:21:05,866 --> 00:21:07,735 CO-CHAIRED AND COFOUNDED THE HIV 619 00:21:07,735 --> 00:21:08,469 CONGRESSIONAL CAUCUS. 620 00:21:08,469 --> 00:21:10,571 ON A SADDER NOTE, THE TEAM PAID 621 00:21:10,571 --> 00:21:12,640 RESPECTS TO MR. CORNELIUS BAKER 622 00:21:12,640 --> 00:21:15,042 WHO WAS AN OAR CONSULTANT AND 623 00:21:15,042 --> 00:21:18,112 LIFELONG HIV ADVOCATE AND HE WAS 624 00:21:18,112 --> 00:21:19,647 LAID TO REST AT THE NATIONAL 625 00:21:19,647 --> 00:21:21,181 CATHEDRAL ON DECEMBER 13TH. 626 00:21:21,181 --> 00:21:23,884 ALSO IN DECEMBER, NIH ANNOUNCED 627 00:21:23,884 --> 00:21:26,420 AWARDS TO ADVANCE TECHNOLOGY FOR 628 00:21:26,420 --> 00:21:29,256 HIV VIRAL LOAD DETECTION, SO 629 00:21:29,256 --> 00:21:30,791 FUNDING AND SUPPORT SERVICES 630 00:21:30,791 --> 00:21:32,660 WERE AWARDED TO THREE DIAGNOSTIC 631 00:21:32,660 --> 00:21:34,395 TECHNOLOGY DEVELOPERS AS PART OF 632 00:21:34,395 --> 00:21:36,931 RADX OR THE RAPID ACCELERATION 633 00:21:36,931 --> 00:21:38,432 OF DIAGNOSTICS. 634 00:21:38,432 --> 00:21:41,201 THESE TECH ADVANCED PLATFORMS 635 00:21:41,201 --> 00:21:42,503 FOR HIV VIRAL LOAD MONITORING 636 00:21:42,503 --> 00:21:43,571 PROGRAM. 637 00:21:43,571 --> 00:21:45,773 SO LAUNCHED IN THE SPRING OF 638 00:21:45,773 --> 00:21:47,441 2024 BY NIBIB IN COLLABORATION 639 00:21:47,441 --> 00:21:50,411 WITH OAR AND NIAID, THIS PROGRAM 640 00:21:50,411 --> 00:21:52,680 IS AIMED AT ADVANCING HIV VIRAL 641 00:21:52,680 --> 00:21:54,415 LOAD DETECTION TECHNOLOGIES FOR 642 00:21:54,415 --> 00:21:55,616 USE AT POINT OF CARE. 643 00:21:55,616 --> 00:21:57,484 SO THE THREE AWARDS THAT ARE 644 00:21:57,484 --> 00:22:03,924 LISTED HERE WERE CEPHE ID IN 645 00:22:03,924 --> 00:22:05,793 CALIFORNIA TO QUANTITATIVELY 646 00:22:05,793 --> 00:22:08,596 DETECT LEVELS OF HIV IN UNDER 90 647 00:22:08,596 --> 00:22:10,297 MINUTES. 648 00:22:10,297 --> 00:22:11,832 BAEBIES, INCORPORATED FROM 649 00:22:11,832 --> 00:22:12,900 DURHAM, NORTH CAROLINA, 650 00:22:12,900 --> 00:22:15,402 OPTIMIZING RT-PCR FOR HIV ASSAY 651 00:22:15,402 --> 00:22:16,637 SENSITIVITY, BLOOD PROCESSING 652 00:22:16,637 --> 00:22:17,838 TECHNIQUES AND VIRAL LOAD 653 00:22:17,838 --> 00:22:18,739 QUANTIFICATION CAPABILITIES, AND 654 00:22:18,739 --> 00:22:28,015 PROMPT TI DIAGNOSTICS IN BALTIM, 655 00:22:28,015 --> 00:22:31,485 MAGNETOFLUIDIC CARTRIDGE 656 00:22:31,485 --> 00:22:32,052 PLATFORM. 657 00:22:32,052 --> 00:22:35,456 THEN ON DECEMBER 17 17THTH, THER 658 00:22:35,456 --> 00:22:39,827 AND FDA CO-HOSTED A JOINT 659 00:22:39,827 --> 00:22:41,328 NIH-FDA NUTRITION REGULATORY 660 00:22:41,328 --> 00:22:42,930 SCIENCE WORKSHOP. 661 00:22:42,930 --> 00:22:44,999 THE GOAL OF THIS JOINT WORKSHOP 662 00:22:44,999 --> 00:22:46,967 IS TO -- WAS REALLY TO HIGHLIGHT 663 00:22:46,967 --> 00:22:48,602 HOW NUTRITION SCIENCE CAN 664 00:22:48,602 --> 00:22:50,471 GENERATE EVIDENCE AND DATA TO 665 00:22:50,471 --> 00:22:52,439 INFORM FOOD-RELATED POLICY AND 666 00:22:52,439 --> 00:22:53,841 REGULATORY DECISION-MAKING AND 667 00:22:53,841 --> 00:22:55,275 TO FOSTER ADDITIONAL 668 00:22:55,275 --> 00:22:57,344 COLLABORATION BETWEEN NIH AND 669 00:22:57,344 --> 00:23:01,081 FDA IN SUPPORTING RESEARCH THAT 670 00:23:01,081 --> 00:23:01,982 ADDRESSES PRIORITY NUTRITION 671 00:23:01,982 --> 00:23:03,050 RESEARCH GAPS. 672 00:23:03,050 --> 00:23:04,918 SO THERE WERE MANY TOPICS THAT 673 00:23:04,918 --> 00:23:06,553 WERE DISCUSSED AT THE WORKSHOP. 674 00:23:06,553 --> 00:23:08,522 THESE INCLUDES ULTRAPROCESSED 675 00:23:08,522 --> 00:23:10,591 FOODS, IMPACT ANALYSIS AND 676 00:23:10,591 --> 00:23:12,126 IMPLEMENTATION SCIENCE RELATED 677 00:23:12,126 --> 00:23:14,728 TO REGULATORY ACTIONS, AND 678 00:23:14,728 --> 00:23:15,863 EMERGING TECHNOLOGICAL 679 00:23:15,863 --> 00:23:17,498 INNOVATIONS RELATED TO NUTRITION 680 00:23:17,498 --> 00:23:19,133 REGULATORY SCIENCE. 681 00:23:19,133 --> 00:23:20,834 AROUND THE SAME TIME, DECEMBER 682 00:23:20,834 --> 00:23:26,573 WAS QUITE A BUSY MONTH, THROW, 683 00:23:26,573 --> 00:23:28,208 THE TRIBAL HEALTH RESEARCH 684 00:23:28,208 --> 00:23:31,178 OFFICE, HELD A 2 1/2 DAY IN 685 00:23:31,178 --> 00:23:32,413 PERSON FEDERAL INDIAN BOARDING 686 00:23:32,413 --> 00:23:33,914 SCHOOL HEALING SUMMIT. 687 00:23:33,914 --> 00:23:36,283 THIS SUMMIT BROUGHT TOGETHER 688 00:23:36,283 --> 00:23:39,720 BOARDING SCHOOL SURVIVORS, 689 00:23:39,720 --> 00:23:42,756 PRACTITIONERS, LEADERS IN TRAUMA 690 00:23:42,756 --> 00:23:44,858 RAO SEARCH AND LEADERS FROM 691 00:23:44,858 --> 00:23:46,593 MULTIPLE NIH ICOs AND FEDERAL 692 00:23:46,593 --> 00:23:47,027 AGENCIES. 693 00:23:47,027 --> 00:23:48,996 THE GOAL HERE WAS TO SHARE 694 00:23:48,996 --> 00:23:50,097 STORIES, IDENTIFY GAPS IN 695 00:23:50,097 --> 00:23:51,732 KNOWLEDGE AND ALIGN PRIORITIES 696 00:23:51,732 --> 00:23:53,834 FOR DEVELOPING INITIATIVES THAT 697 00:23:53,834 --> 00:23:55,636 EMBRACE A WHOLE OF GOVERNMENT 698 00:23:55,636 --> 00:23:57,337 AND COMMUNITY INFORMED APPROACH 699 00:23:57,337 --> 00:23:59,506 TO ADDRESSING BOARDING SCHOOL 700 00:23:59,506 --> 00:24:00,708 AND INTERGENERATIONAL TRAUMA 701 00:24:00,708 --> 00:24:03,410 HEALING. 702 00:24:03,410 --> 00:24:05,746 THEN MOST RECENTLY, ODS HAS 703 00:24:05,746 --> 00:24:08,348 RELEASED THEIR STRATEGIC PLAN 704 00:24:08,348 --> 00:24:10,784 FOR 2025 THROUGH 2029. 705 00:24:10,784 --> 00:24:13,220 THIS STRATEGIC PLAN OUTLINES 706 00:24:13,220 --> 00:24:15,589 THREE PRIMARY GOALS: ADVANCE 707 00:24:15,589 --> 00:24:17,324 RESEARCH, EXPAND CAPACITY AND 708 00:24:17,324 --> 00:24:19,393 FOSTER STEWARDSHIP, THAT WILL 709 00:24:19,393 --> 00:24:25,099 ENABLE ODS TO BUILD 710 00:24:25,099 --> 00:24:26,867 UNDERSTANDING OF HOW DIETARY 711 00:24:26,867 --> 00:24:28,035 SUPPLEMENTS MODULATE RESILIENCE 712 00:24:28,035 --> 00:24:30,471 AND HEALTH ACROSS THE LIFESPAN 713 00:24:30,471 --> 00:24:34,308 IN HETEROGENEOUS POPULATION. 714 00:24:34,308 --> 00:24:34,742 S. 715 00:24:34,742 --> 00:24:36,310 THEN THE COMMON FUND VENTURE 716 00:24:36,310 --> 00:24:38,912 PROGRAM WHICH YOU ALL HEARD 717 00:24:38,912 --> 00:24:40,748 DISCUSSED HERE, A NEW FORM OF 718 00:24:40,748 --> 00:24:42,182 COMMON FUND SUPPORT IS ACTUALLY 719 00:24:42,182 --> 00:24:44,685 PROVIDING A FRAMEWORK TO DEVELOP 720 00:24:44,685 --> 00:24:45,919 SHORT-TERM PROJECTS WITH THE 721 00:24:45,919 --> 00:24:48,622 POTENTIAL FOR SIGNIFICANT 722 00:24:48,622 --> 00:24:51,391 OUTSIZED IMPACT HAS RECENTLY 723 00:24:51,391 --> 00:24:54,862 LAUNCHED ITS TWO INITIATIVES. 724 00:24:54,862 --> 00:24:56,063 SO THE FIRST OF THESE 725 00:24:56,063 --> 00:24:57,264 INITIATIVES IS AN EFFORT TO 726 00:24:57,264 --> 00:24:59,366 INTEGRATE VARIOUS DATA TYPES 727 00:24:59,366 --> 00:25:00,534 THAT ALLOW RESEARCHERS TO 728 00:25:00,534 --> 00:25:02,503 EXPLORE THE ROLE OF A SPECIFIC 729 00:25:02,503 --> 00:25:04,805 GENE, MOLECULE, CELL OR PATHWAY 730 00:25:04,805 --> 00:25:06,306 ACROSS TISSUES INVOLVED IN 731 00:25:06,306 --> 00:25:08,208 DIFFERENT DISEASE. 732 00:25:08,208 --> 00:25:11,345 AND OCULOMICS, TO DEVELOP AND 733 00:25:11,345 --> 00:25:13,313 APPLY NOVEL NONINVASIVE EYE 734 00:25:13,313 --> 00:25:14,748 IMAGING TECHNOLOGIES, MACHINE 735 00:25:14,748 --> 00:25:15,749 LEARNING ALGORITHMS AND OTHER 736 00:25:15,749 --> 00:25:17,284 TOOLS TO IDENTIFY HIGHLY 737 00:25:17,284 --> 00:25:18,786 SENSITIVE AND SPECIFIC 738 00:25:18,786 --> 00:25:20,120 BIOMARKERS FOR DISEASES THAT 739 00:25:20,120 --> 00:25:22,089 AFFECT THE ENTIRE BODY. 740 00:25:22,089 --> 00:25:25,025 SO BOTH INITIATIVES MADE AWARDS 741 00:25:25,025 --> 00:25:28,095 AND HELD KICKOFF MEETINGS. 742 00:25:28,095 --> 00:25:31,498 THEN ODP IS PARTNERING WITH THE 743 00:25:31,498 --> 00:25:33,033 CDC'S OFFICE ON SMOKING AND 744 00:25:33,033 --> 00:25:36,203 HEALTH TO SPONSOR THE QUIT AND 745 00:25:36,203 --> 00:25:38,038 THRIVE CHALLENGE, 746 00:25:38,038 --> 00:25:38,806 COMMUNITY-DERIVED SOLUTIONS TO 747 00:25:38,806 --> 00:25:40,174 REDUCE MENTHOL CIGARETTE 748 00:25:40,174 --> 00:25:40,440 SMOKING. 749 00:25:40,440 --> 00:25:41,975 SO THE GOAL OF THIS CHALLENGE 750 00:25:41,975 --> 00:25:43,844 WAS TO SHOWCASE COMMUNITY 751 00:25:43,844 --> 00:25:45,179 GENERATED SOLUTIONS THAT HAVE 752 00:25:45,179 --> 00:25:46,914 REDUCED MENTHOL CIGARETTE 753 00:25:46,914 --> 00:25:48,649 SMOKING AMONG GROUPS WITH 754 00:25:48,649 --> 00:25:49,983 DISPROPORTIONATELY HIGH RATES OF 755 00:25:49,983 --> 00:25:52,286 USE, AND OF COURSE THAT INCLUDES 756 00:25:52,286 --> 00:25:54,221 YOUTH AND MINORITIES AND PEOPLE 757 00:25:54,221 --> 00:25:56,190 WITH LOWER INCOMES. 758 00:25:56,190 --> 00:25:58,592 THESE SOLUTIONS MAY BE USED TO 759 00:25:58,592 --> 00:26:00,127 INFORM FUTURE FEDERALLY FUNDED 760 00:26:00,127 --> 00:26:01,461 RESEARCH INITIATIVES OR 761 00:26:01,461 --> 00:26:03,197 DEMONSTRATION PROJECTS. 762 00:26:03,197 --> 00:26:05,299 UP TO NINE PRIZES OF $100,000 763 00:26:05,299 --> 00:26:08,135 EACH WILL BE AWARDED TO WINNING 764 00:26:08,135 --> 00:26:11,939 ORGANIZATIONS IN JULY OF 2025. 765 00:26:11,939 --> 00:26:15,442 SO I REALLY WISH THAT I HAD MORE 766 00:26:15,442 --> 00:26:16,543 TIME TO CONTINUE SHARING ALL OF 767 00:26:16,543 --> 00:26:17,611 THE WONDERFUL PROGRESS AND 768 00:26:17,611 --> 00:26:19,112 UPDATES WE HAVE AS A DIVISION, 769 00:26:19,112 --> 00:26:21,481 BUT I WILL HAVE TO STOP FOR NOW 770 00:26:21,481 --> 00:26:22,883 SO THAT WE CAN GET TO THE REST 771 00:26:22,883 --> 00:26:25,519 OF OUR AGENDA. 772 00:26:25,519 --> 00:26:31,325 OF AND SO THESO THE LAST THING Y 773 00:26:31,325 --> 00:26:32,726 BEFORE WE MOVE INTO THE CONCEPT 774 00:26:32,726 --> 00:26:33,627 CLEARANCES IS THAT DPCPSI IS 775 00:26:33,627 --> 00:26:34,828 ACTUALLY LEADING DEVELOPMENT OF 776 00:26:34,828 --> 00:26:36,496 THE AGENCY-WIDE NIH STRATEGIC 777 00:26:36,496 --> 00:26:38,866 PLAN FOR DISABILITY HEALTH 778 00:26:38,866 --> 00:26:39,299 RESEARCH. 779 00:26:39,299 --> 00:26:42,035 SO THIS IS A PROSPECTIVE EFFORT 780 00:26:42,035 --> 00:26:44,271 THAT WE'RE UNDERGOING THE 781 00:26:44,271 --> 00:26:45,305 PLANNING AND DEVELOPMENT PROCESS 782 00:26:45,305 --> 00:26:46,406 FOR RIGHT NOW. 783 00:26:46,406 --> 00:26:48,375 SO THROUGH THE NIH DISABILITY 784 00:26:48,375 --> 00:26:49,810 HEALTH RESEARCH COORDINATING 785 00:26:49,810 --> 00:26:50,944 COMMITTEE, WE BROUGHT TOGETHER 786 00:26:50,944 --> 00:26:53,513 SUBJECT MATTER EXPERTS FROM 24 787 00:26:53,513 --> 00:26:55,816 ICs AND 18 OFFICES AND 788 00:26:55,816 --> 00:26:57,117 PROGRAMS TO SHARE RESEARCH 789 00:26:57,117 --> 00:26:59,086 ADVANCES AND COLLABORATE. 790 00:26:59,086 --> 00:27:01,288 WE ALSO HOSTED SIX COMMUNITY 791 00:27:01,288 --> 00:27:03,490 ROUNDTABLE DISCUSSIONS AND A 792 00:27:03,490 --> 00:27:04,658 PUBLIC TOWN HALL TO GAIN 793 00:27:04,658 --> 00:27:06,627 INSIGHTS FROM PEOPLE WITH 794 00:27:06,627 --> 00:27:08,161 DISABILITIES, RESEARCHERS AND 795 00:27:08,161 --> 00:27:10,364 CLINICIANS AND PROFESSIONAL 796 00:27:10,364 --> 00:27:12,232 ASSOCIATIONS AND ADVOCACY 797 00:27:12,232 --> 00:27:13,967 ORGANIZATIONS, AND THEN WE ALSO 798 00:27:13,967 --> 00:27:15,936 PUBLISHED AN RFI TO OBTAIN 799 00:27:15,936 --> 00:27:17,404 PUBLIC FEEDBACK ON THE DRAFT 800 00:27:17,404 --> 00:27:18,605 FRAMEWORK FOR THE STRATEGIC PLAN 801 00:27:18,605 --> 00:27:20,340 AND WE RECEIVED OVER 140 802 00:27:20,340 --> 00:27:22,609 RESPONSES TO THAT. 803 00:27:22,609 --> 00:27:24,144 SO THE STRATEGIC PLAN WILL BE 804 00:27:24,144 --> 00:27:25,212 RELEASED LATER THIS YEAR AND 805 00:27:25,212 --> 00:27:26,580 AFTER THIS MEETING, WE WILL BE 806 00:27:26,580 --> 00:27:27,447 SENDING INVITATIONS TO THE 807 00:27:27,447 --> 00:27:29,516 COUNCIL OF COUNCILS DISABILITY 808 00:27:29,516 --> 00:27:32,252 HEALTH RESEARCH WORKING GROUP. 809 00:27:32,252 --> 00:27:34,221 OKAY. 810 00:27:34,221 --> 00:27:40,460 SO NOW WE WILL BE MOVING INTO 811 00:27:40,460 --> 00:27:41,161 THE CONCEPT CLEARANCE PORTION OF 812 00:27:41,161 --> 00:27:42,195 THE AGENDA. 813 00:27:42,195 --> 00:27:46,900 FIRST UP WE HAVE A CONCEPT 814 00:27:46,900 --> 00:27:49,002 CLEARANCE FROM THE OFFICE OF 815 00:27:49,002 --> 00:27:49,870 RESEARCH INFRASTRUCTURE PROGRAMS 816 00:27:49,870 --> 00:27:51,505 OR ORIP. 817 00:27:51,505 --> 00:27:52,940 DR. RITESH TANDON, PROGRAM 818 00:27:52,940 --> 00:27:54,341 DIRECTOR IN THE DIVISION OF 819 00:27:54,341 --> 00:27:55,742 COMPARATIVE MEDICINE IN ORIP, 820 00:27:55,742 --> 00:27:57,744 WILL PRESENT A REISSUE OF THE 821 00:27:57,744 --> 00:28:00,047 CONCEPT ENTITLED LIMITED 822 00:28:00,047 --> 00:28:00,914 COMPETITION, SMALL GRANT PROGRAM 823 00:28:00,914 --> 00:28:05,185 FOR ORIP SPECIAL EMPHASIS CAREER 824 00:28:05,185 --> 00:28:09,756 RESEARCH AWARD OR SERCA. 825 00:28:09,756 --> 00:28:10,991 THIS PRESENTATION WILLING 826 00:28:10,991 --> 00:28:12,960 FOLLOWED I ABOUT TWO ASSIGNED 827 00:28:12,960 --> 00:28:14,261 COUNCILMEMBER DISCUSSANTS, 828 00:28:14,261 --> 00:28:16,563 DR. SUSAN SANCHEZ AND DR. MONICA 829 00:28:16,563 --> 00:28:17,998 GANDHI. 830 00:28:17,998 --> 00:28:27,307 RITESH, OVER TO YOU. 831 00:28:27,307 --> 00:28:28,775 >> GOOD MORNING. 832 00:28:28,775 --> 00:28:30,243 CAN YOU ALL HEAR ME? 833 00:28:30,243 --> 00:28:40,520 YES, THANK YOU. 834 00:28:54,401 --> 00:29:01,708 >> WE CAN'T HEAR YOU NOW. 835 00:29:01,708 --> 00:29:02,342 >> OKAY. 836 00:29:02,342 --> 00:29:03,243 CAN YOU HEAR ME NOW? 837 00:29:03,243 --> 00:29:03,677 >> YES. 838 00:29:03,677 --> 00:29:04,244 >> OKAY. 839 00:29:04,244 --> 00:29:08,181 CAN YOU SEE MY CAMERA? 840 00:29:08,181 --> 00:29:09,082 >> NO. 841 00:29:09,082 --> 00:29:09,683 >> NO? 842 00:29:09,683 --> 00:29:19,793 OKAY. 843 00:29:37,577 --> 00:29:42,082 >> SORRY TE SO RITESH, IT LOOKSR 844 00:29:42,082 --> 00:29:43,450 CAMERA IS BLACKED OUT. 845 00:29:43,450 --> 00:29:45,218 I DON'T KNOW IF IT'S TECHNICAL 846 00:29:45,218 --> 00:29:46,620 ISSUES OR A MATTER OF SWITCHING 847 00:29:46,620 --> 00:29:47,387 IT ON. 848 00:29:47,387 --> 00:29:49,156 I GET FROM MY TECHNICAL 849 00:29:49,156 --> 00:29:50,023 COLLEAGUES HERE A NODDING THAT 850 00:29:50,023 --> 00:29:51,658 IT PROBABLY JUST A TECHNICAL 851 00:29:51,658 --> 00:29:51,958 ISSUE. 852 00:29:51,958 --> 00:29:57,798 SO WHY DON'T YOU JUST PRESENT 853 00:29:57,798 --> 00:29:59,332 AND WE JUST WON'T SEE YOU WHILE 854 00:29:59,332 --> 00:30:00,000 YOU'RE PRESENTING. 855 00:30:00,000 --> 00:30:01,101 THAT MAKES MORE SENSE TO ME. 856 00:30:01,101 --> 00:30:02,035 >> WE CAN SEE NOW. 857 00:30:02,035 --> 00:30:03,537 >> OKAY, GREAT. 858 00:30:03,537 --> 00:30:04,371 >> NOW WE CAN SEE YOU. 859 00:30:04,371 --> 00:30:04,738 >> GREAT. 860 00:30:04,738 --> 00:30:06,139 THANK YOU SO MUCH. 861 00:30:06,139 --> 00:30:07,874 SO GOOD MORNING, EVERYONE. 862 00:30:07,874 --> 00:30:09,976 I WOULD LIKE TO BRIEFLY 863 00:30:09,976 --> 00:30:11,078 INTRODUCE FOR THE CONCEPT 864 00:30:11,078 --> 00:30:13,346 CLEARANCE THE REISSUE OF THE 865 00:30:13,346 --> 00:30:15,782 UNIQUE SMALL GRANT PROGRAM FOR 866 00:30:15,782 --> 00:30:17,084 ORIP VETERINARY SCIENTIST 867 00:30:17,084 --> 00:30:20,487 SPECIAL EMPHASIS RESEARCH CAREER 868 00:30:20,487 --> 00:30:23,857 AWARD, SERCA K01 RECIPIENTS 869 00:30:23,857 --> 00:30:25,392 USING THE R03 MECHANISM. 870 00:30:25,392 --> 00:30:27,160 THE OBJECTIVE OF THIS PROGRAM IS 871 00:30:27,160 --> 00:30:30,997 TO FACILITATE SERCA 872 00:30:30,997 --> 00:30:32,332 K01 RECIPIENTS' TRANSITION TO 873 00:30:32,332 --> 00:30:36,236 INDEPENDENCE BY ELEVATING 874 00:30:36,236 --> 00:30:39,873 FINANCIAL IND AGAINST, KEM 875 00:30:39,873 --> 00:30:41,074 DEMONSTRATING ADDITIONAL SUCCESS 876 00:30:41,074 --> 00:30:42,609 IN PEER REVIEW COMPETITIONS AND 877 00:30:42,609 --> 00:30:43,810 GENERATING ADDITIONAL DATA AND 878 00:30:43,810 --> 00:30:44,911 PUBLICATIONS IN SUPPORT OF 879 00:30:44,911 --> 00:30:47,414 FUTURE R01 OR EQUIVALENT GRANT 880 00:30:47,414 --> 00:30:50,617 APPLICATIONS. 881 00:30:50,617 --> 00:30:51,818 THE FUNDS AVAILABLE AND THE 882 00:30:51,818 --> 00:30:53,019 ANTICIPATED NUMBER OF AWARDS FOR 883 00:30:53,019 --> 00:30:55,989 THIS PROGRAM ARE CONTINGENT UPON 884 00:30:55,989 --> 00:30:58,625 NIH APPROPRIATIONS AND HOW MANY 885 00:30:58,625 --> 00:30:59,226 MERITORIOUS APPLICATIONS ARE 886 00:30:59,226 --> 00:31:00,927 SUBMITTED IN A GIVEN CYCLE. 887 00:31:00,927 --> 00:31:02,229 THE AWARD PROJECT PERIOD IS FOR 888 00:31:02,229 --> 00:31:03,029 TWO YEARS. 889 00:31:03,029 --> 00:31:04,798 AND THE COUNCIL ACTION THAT WILL 890 00:31:04,798 --> 00:31:06,766 BE UNDER DISCUSSION IS A VOTE 891 00:31:06,766 --> 00:31:08,401 FOR CONTINUED SUPPORT OF THE 892 00:31:08,401 --> 00:31:11,605 SMALL GRANT PROGRAM FOR ORIP 893 00:31:11,605 --> 00:31:13,440 VETERINARY SCIENTIST SERCA 894 00:31:13,440 --> 00:31:18,044 K01 RECIPIENTS. 895 00:31:18,044 --> 00:31:21,581 TO GIVE YOU SOME BACKGROUND ON 896 00:31:21,581 --> 00:31:24,284 ORIP'S R03 PROGRAM, ORIP 897 00:31:24,284 --> 00:31:26,019 SUPPORTS SERCA K01 GRANTS UNDER 898 00:31:26,019 --> 00:31:28,121 THE MENTORED RESEARCH SCIENTIST 899 00:31:28,121 --> 00:31:31,491 AWARD PARENT K01 FOR DEVELOPING 900 00:31:31,491 --> 00:31:32,259 VETERINARY SCIENTISTS. 901 00:31:32,259 --> 00:31:34,161 THE PROGRAM IS UNIQUE AT NIH 902 00:31:34,161 --> 00:31:36,863 BECAUSE IT SPECIFICALLY SUPPORTS 903 00:31:36,863 --> 00:31:38,965 VETERINARY SCIENTISTS AND 904 00:31:38,965 --> 00:31:40,600 PROVIDES MENTORED EXPERIENCE TO 905 00:31:40,600 --> 00:31:42,369 HELP EARLY STAGE VETERINARY 906 00:31:42,369 --> 00:31:43,436 SCIENTISTS TRANSITION INTO 907 00:31:43,436 --> 00:31:45,305 INDEPENDENT INVESTIGATORS 908 00:31:45,305 --> 00:31:46,873 FOCUSING ON COMPARATIVE 909 00:31:46,873 --> 00:31:48,608 MEDICINE, BIOMEDICAL RESEARCH, 910 00:31:48,608 --> 00:31:51,912 AND TRANSLATIONAL SCIENCES. 911 00:31:51,912 --> 00:31:52,979 VETERINARY SCIENTISTS BRING 912 00:31:52,979 --> 00:31:54,548 UNIQUE KNOWLEDGE OF COMPARATIVE 913 00:31:54,548 --> 00:31:55,649 BIOLOGY THAT IS IMPORTANT FOR 914 00:31:55,649 --> 00:31:58,051 THE DEVELOPMENT AND REFINEMENT 915 00:31:58,051 --> 00:32:01,121 OF ANIMAL MODELS OF HUMAN 916 00:32:01,121 --> 00:32:02,656 DISEASES, AS WELL AS 917 00:32:02,656 --> 00:32:03,657 RECOMMENDATIONS ON ALTERNATIVES 918 00:32:03,657 --> 00:32:04,958 TO ANIMAL MODELS. 919 00:32:04,958 --> 00:32:07,060 THE TRANSITION FROM K GRANT TO R 920 00:32:07,060 --> 00:32:09,129 GRANT IS A CRITICAL CAREER 921 00:32:09,129 --> 00:32:09,896 JUNCTURE. 922 00:32:09,896 --> 00:32:12,098 RECOGNIZING THE CHALLENGES OF 923 00:32:12,098 --> 00:32:14,834 THIS PHASE, SEVERAL NIH 924 00:32:14,834 --> 00:32:16,136 INSTITUTES HAVE SUCCESSFULLY 925 00:32:16,136 --> 00:32:18,104 USED LIMITED COMPETITION 926 00:32:18,104 --> 00:32:19,439 R03 GRANT PROGRAM TO SUPPLEMENT 927 00:32:19,439 --> 00:32:20,974 THE CAREER DEVELOPMENT OF THEIR 928 00:32:20,974 --> 00:32:24,477 K GRANT RECIPIENTS DURING THE 929 00:32:24,477 --> 00:32:25,712 LAST TWO GRANT AWARD YEARS. 930 00:32:25,712 --> 00:32:27,547 THE INTENT OF THESE R03 PROGRAMS 931 00:32:27,547 --> 00:32:29,316 IS TO INCREASE THE SUCCESS RATE 932 00:32:29,316 --> 00:32:31,851 OF NEW INVESTIGATORS BY APPLYING 933 00:32:31,851 --> 00:32:33,920 FOR R01 OR EQUIVALENT GRANTS, 934 00:32:33,920 --> 00:32:34,921 WHICH HAS BEEN SHOWN BY OTHER 935 00:32:34,921 --> 00:32:39,726 PROGRAMS. 936 00:32:39,726 --> 00:32:41,928 ORIP ESTABLISHEDDITY OWN 937 00:32:41,928 --> 00:32:50,237 R03 PROGRAM FOR SERCA 938 00:32:50,237 --> 00:32:51,004 KO1 RECIPIENTS. 939 00:32:51,004 --> 00:32:52,005 THIS PROGRAM ENHANCES THE 940 00:32:52,005 --> 00:32:54,841 ABILITY OF AWARDEES TO CONDUCT 941 00:32:54,841 --> 00:32:55,942 RESEARCH AS THEY TRANSITION TO 942 00:32:55,942 --> 00:32:57,377 BECOMING INDEPENDENT 943 00:32:57,377 --> 00:32:59,112 RESEARCHERS, AND ALIGNS WITH 944 00:32:59,112 --> 00:33:00,447 ORIP'S MISSION TO SUPPORT 945 00:33:00,447 --> 00:33:01,748 RESEARCH TRAINING OPPORTUNITIES 946 00:33:01,748 --> 00:33:04,918 FOR VETERINARY SCIENTISTS. 947 00:33:04,918 --> 00:33:07,887 SINCE JUNE 2017, 3 NOTICES OF 948 00:33:07,887 --> 00:33:09,322 FUNDING OPPORTUNITIES OR NOFOs 949 00:33:09,322 --> 00:33:10,991 HAVE BEEN ISSUED AND ARE LISTED 950 00:33:10,991 --> 00:33:11,758 HERE. 951 00:33:11,758 --> 00:33:13,393 I SHOULD MENTION THAT THE NOFO 952 00:33:13,393 --> 00:33:15,362 WAS RECENTLY REISSUED AT THE END 953 00:33:15,362 --> 00:33:17,330 OF MARCH TO ALIGN WITH 954 00:33:17,330 --> 00:33:21,067 ADMINISTRATIVE PRIORITIES. 955 00:33:21,067 --> 00:33:23,603 A SINGLE AND -- DEADLINE -- THAT 956 00:33:23,603 --> 00:33:25,238 LEFT MANY APPLICANTS WITH LITTLE 957 00:33:25,238 --> 00:33:28,942 OR NO CHANCE OF BEING ELIGIBLE 958 00:33:28,942 --> 00:33:32,379 TO SUBMIT AN APPLICATION IF THE 959 00:33:32,379 --> 00:33:33,246 ORIGINAL APPLICATION WAS NOT 960 00:33:33,246 --> 00:33:33,913 FUNDED. 961 00:33:33,913 --> 00:33:36,082 ESPECIALLY CONSIDERING THESE ARE 962 00:33:36,082 --> 00:33:37,984 TRAINEES EAGER TO MOVE ON TO 963 00:33:37,984 --> 00:33:39,286 THEIR NEXT CAREER STAGE, THE 964 00:33:39,286 --> 00:33:40,987 PROGRAM CHANGED THE DEADLINE TO 965 00:33:40,987 --> 00:33:43,890 THREE TIMES A YEAR STARTING WITH 966 00:33:43,890 --> 00:33:48,194 THE 2023 NOFO. 967 00:33:48,194 --> 00:33:54,634 THE ORIP R03 PROGRAM ALIGNS WITH 968 00:33:54,634 --> 00:33:56,503 STRATEGY 3.1 OF THE STRATEGIC 969 00:33:56,503 --> 00:33:59,172 PLAN 2021-2025 WHICH PROMOTES 970 00:33:59,172 --> 00:34:05,712 INOINNOVATING APPROACHES TO 971 00:34:05,712 --> 00:34:08,114 TRAINING AND DEVELOPMENT WORKING 972 00:34:08,114 --> 00:34:11,718 IN BIOMEDICAL RESEARCH, 973 00:34:11,718 --> 00:34:12,786 INVESTING AND SUPPORTING THE 974 00:34:12,786 --> 00:34:14,054 CAREER DEVELOPMENT AND TRAINING 975 00:34:14,054 --> 00:34:15,922 THAT PREPARES GRADUATE 976 00:34:15,922 --> 00:34:17,123 VETERINARIANS TO PURSUE RESEARCH 977 00:34:17,123 --> 00:34:19,626 THAT FILLS MAJOR GAPS IN 978 00:34:19,626 --> 00:34:21,828 BIOMEDICAL AND BIOBEHAVIORAL 979 00:34:21,828 --> 00:34:23,463 SCIENCE AND EXPANDS KNOWLEDGE IN 980 00:34:23,463 --> 00:34:25,465 EMERGING AREAS CRITICAL TO HUMAN 981 00:34:25,465 --> 00:34:26,433 HEALTH. 982 00:34:26,433 --> 00:34:28,301 THIS R03 PROGRAM PROVIDES ACCESS 983 00:34:28,301 --> 00:34:29,936 TO RESEARCH SUPPORT THAT ALLOWS 984 00:34:29,936 --> 00:34:31,037 EARLY STAGE VETERINARY 985 00:34:31,037 --> 00:34:32,706 SCIENTISTS TO PURSUE UNIQUE 986 00:34:32,706 --> 00:34:33,973 RESEARCH DIRECTIONS, INDEPENDENT 987 00:34:33,973 --> 00:34:37,210 OF THE FUNDING SUPPORT OF THEIR 988 00:34:37,210 --> 00:34:37,977 MENTORS, FACILITATE THEIR 989 00:34:37,977 --> 00:34:39,279 TRANSITION TO INDEPENDENCE, AND 990 00:34:39,279 --> 00:34:41,581 INCREASE THEIR COMPETITIVENESS 991 00:34:41,581 --> 00:34:47,821 FOR R01 OR EQUIVALENT GRANTS. 992 00:34:47,821 --> 00:34:49,489 THE PROPOSED R03 PROGRAM 993 00:34:49,489 --> 00:34:50,824 INITIATIVE IS INTENDED TO 994 00:34:50,824 --> 00:34:51,558 SUPPORT RESEARCH PROJECTS THAT 995 00:34:51,558 --> 00:34:53,793 CAN BE CARRIED OUT IN A SHORT 996 00:34:53,793 --> 00:34:55,528 PERIOD OF TIME, WITH LIMITED 997 00:34:55,528 --> 00:34:57,063 RESOURCES AND THAT MAY PROVIDE 998 00:34:57,063 --> 00:34:58,398 PRELIMINARY DATA TO SUPPORT A 999 00:34:58,398 --> 00:35:00,667 SUBSEQUENT R01 OR EQUIVALENT 1000 00:35:00,667 --> 00:35:01,801 APPLICATION. 1001 00:35:01,801 --> 00:35:03,503 PROJECTS THAT WOULD BE SUPPORTED 1002 00:35:03,503 --> 00:35:05,939 INCLUDE PILOT AND FEASIBILITY 1003 00:35:05,939 --> 00:35:07,507 STUDIES, SECONDARY ANALYSES OF 1004 00:35:07,507 --> 00:35:10,143 EXISTING DATA, A SMALL, 1005 00:35:10,143 --> 00:35:11,010 SELF-CONTAINED RESEARCH 1006 00:35:11,010 --> 00:35:12,112 PROJECTS, DEVELOPMENT OF 1007 00:35:12,112 --> 00:35:13,246 RESEARCH METHODOLOGY, AND 1008 00:35:13,246 --> 00:35:14,547 DEVELOPMENT OF NEW RESEARCH 1009 00:35:14,547 --> 00:35:20,787 TECHNOLOGY. 1010 00:35:20,787 --> 00:35:25,291 ORIP'S R03 PROGRAM IS LIMITED TO 1011 00:35:25,291 --> 00:35:27,794 SERCA KO1 AWARDEES WHO ARE 1012 00:35:27,794 --> 00:35:29,229 ELIGIBLE AFTER COMPLETION OF THE 1013 00:35:29,229 --> 00:35:30,663 FIRST TWO YEARS OR 24 MONTHS OF 1014 00:35:30,663 --> 00:35:32,198 THEIR K31 AWARD. 1015 00:35:32,198 --> 00:35:34,300 HOWEVER, THEY ARE INELIGIBLE IF 1016 00:35:34,300 --> 00:35:36,603 THEY ALREADY SUCCESSFULLY 1017 00:35:36,603 --> 00:35:39,139 COMPETED FOR AN R01 OR 1018 00:35:39,139 --> 00:35:41,107 EQUIVALENT AWARD. 1019 00:35:41,107 --> 00:35:43,176 THE SERCA KO1 AWARD MUST BE 1020 00:35:43,176 --> 00:35:43,977 ACTIVE. 1021 00:35:43,977 --> 00:35:45,412 AWARDEES MAY RECEIVE FUNDING FOR 1022 00:35:45,412 --> 00:35:50,984 ONLY ONE RSM 03 GRANT AWARD AND 1023 00:35:50,984 --> 00:35:52,018 R03 APPLICANT CAN REQUEST A 1024 00:35:52,018 --> 00:35:54,621 BUDGET UP TO $150,000 IN DIRECT 1025 00:35:54,621 --> 00:35:57,557 COSTS FOR UP TO TWO YEARS. 1026 00:35:57,557 --> 00:35:59,859 THE PROGRAM HAS ACHIEVED NOTABLE 1027 00:35:59,859 --> 00:36:01,828 SUCCESS SINCE BEING ESTABLISHED. 1028 00:36:01,828 --> 00:36:03,730 WITH THE FIRST NOFO BEING 1029 00:36:03,730 --> 00:36:05,498 RELEASED IN FISCAL YEAR 2017, 1030 00:36:05,498 --> 00:36:07,434 FOLLOWED BY RECEIPT OF THE FIRST 1031 00:36:07,434 --> 00:36:09,169 ROUND OF APPLICATIONS ELIGIBLE 1032 00:36:09,169 --> 00:36:11,104 FOR SUBMISSION IN FISCAL YEAR 1033 00:36:11,104 --> 00:36:11,871 2018. 1034 00:36:11,871 --> 00:36:16,276 13 R03 AWARDS WERE MADE BETWEEN 1035 00:36:16,276 --> 00:36:18,044 2019 AND 2024 FROM AMONG 1036 00:36:18,044 --> 00:36:20,313 42 APPLICATIONS SUBMITTED 1037 00:36:20,313 --> 00:36:23,750 BETWEEN FISCAL YEAR 2018 TO 1038 00:36:23,750 --> 00:36:23,950 2024. 1039 00:36:23,950 --> 00:36:28,655 THIS IS A 31% AWARD RATE. 1040 00:36:28,655 --> 00:36:30,657 IN FISCAL YEAR 2025, SEVEN OF 1041 00:36:30,657 --> 00:36:33,927 THE 13 GRANTEES HAD ALREADY 1042 00:36:33,927 --> 00:36:37,530 APPLIED FOR NIH R01 GRANTS WHILE 1043 00:36:37,530 --> 00:36:38,631 THREE GRANTEES HAVE ALREADY BEEN 1044 00:36:38,631 --> 00:36:40,099 AWARDED R01 GRANTS. 1045 00:36:40,099 --> 00:36:42,368 AFTER RECEIVING R03 GRANTS, 1046 00:36:42,368 --> 00:36:44,471 SEVEN GRANTEES HAVE ADVANCED IN 1047 00:36:44,471 --> 00:36:46,105 FOLLOWING YEARS TO THE RANK OF 1048 00:36:46,105 --> 00:36:47,874 ASSOCIATE PROFESSOR AND ONE 1049 00:36:47,874 --> 00:36:49,108 GRANTEE TO ASSISTANT PROFESSOR. 1050 00:36:49,108 --> 00:36:52,045 THE REMAINING GRANTEES HAVE 1051 00:36:52,045 --> 00:36:53,346 MAINTAINED THEIR POSITIONS WITH 1052 00:36:53,346 --> 00:36:56,483 FOUR GRANTEES IN ASSISTANT AND 1053 00:36:56,483 --> 00:36:59,185 ONE AS ASSOCIATE PROFESSOR. 1054 00:36:59,185 --> 00:37:01,387 THE 13 GRANTEES COLLECTIVELY 1055 00:37:01,387 --> 00:37:02,789 HAVE 16 PUBLICATIONS, 13 1056 00:37:02,789 --> 00:37:03,923 RESEARCH, ONE REVIEW, AND TWO 1057 00:37:03,923 --> 00:37:05,258 CLINICAL ARTICLES, ASSOCIATED 1058 00:37:05,258 --> 00:37:06,659 WITH THE R03 GRANTS. 1059 00:37:06,659 --> 00:37:08,962 15 OF THESE PUBLICATIONS ARE 1060 00:37:08,962 --> 00:37:10,830 SENIOR AUTHOR PUBLICATIONS, 1061 00:37:10,830 --> 00:37:12,265 INDICATING THE INDEPENDENT 1062 00:37:12,265 --> 00:37:14,467 STATUS OF AWARDEES. 1063 00:37:14,467 --> 00:37:16,102 AN ANALYSIS OF THE TRANSLATIONAL 1064 00:37:16,102 --> 00:37:17,570 IMPACT OF THESE PUBLICATIONS WAS 1065 00:37:17,570 --> 00:37:22,909 DONE USING EYESIGHT, A TOOL 1066 00:37:22,909 --> 00:37:24,010 DEVELOPED WITHIN THE OFFICE OF 1067 00:37:24,010 --> 00:37:25,211 THE NIH DIRECTOR. 1068 00:37:25,211 --> 00:37:28,748 THIS TOOL GENERATES A 1069 00:37:28,748 --> 00:37:29,449 TRANSLATIONAL PYRAMID SHOWING 1070 00:37:29,449 --> 00:37:31,384 ARTICLE DENSITY BETWEEN HUMAN, 1071 00:37:31,384 --> 00:37:34,687 ANIMAL AND MOLECULAR CELLULAR 1072 00:37:34,687 --> 00:37:34,988 VERTICES. 1073 00:37:34,988 --> 00:37:36,456 WITH RED AND WARMER COLORS 1074 00:37:36,456 --> 00:37:37,657 REFLECTING A HIGH ARTICLE 1075 00:37:37,657 --> 00:37:40,827 DENSITY WHILE BLUE OR COOLER 1076 00:37:40,827 --> 00:37:42,729 COLORS REFLECT LOW ARTICLE 1077 00:37:42,729 --> 00:37:43,062 DENSITY. 1078 00:37:43,062 --> 00:37:44,697 AS SHOWN IN THE FIGURE TO YOUR 1079 00:37:44,697 --> 00:37:45,899 RIGHT, PUBLICATIONS FROM THESE 1080 00:37:45,899 --> 00:37:48,434 AWARDS CLUSTER BETWEEN ANIMAL 1081 00:37:48,434 --> 00:37:50,069 ORIENTED RESEARCH AND MOLECULAR 1082 00:37:50,069 --> 00:37:51,170 CELLULAR RESEARCH. 1083 00:37:51,170 --> 00:37:52,505 INDICATING THAT THE AWARDS 1084 00:37:52,505 --> 00:37:53,973 PRIMARILY SUPPORTED 1085 00:37:53,973 --> 00:37:56,276 PRETRANSLATIONAL RESEARCH. 1086 00:37:56,276 --> 00:37:58,211 AND UPWARD MOVEMENT TO 1087 00:37:58,211 --> 00:37:59,312 TRANSLATIONAL RESEARCH IS 1088 00:37:59,312 --> 00:38:00,880 EXPECTED AS AWARDEES PROGRESS 1089 00:38:00,880 --> 00:38:02,215 FURTHER IN THEIR CAREER. 1090 00:38:02,215 --> 00:38:05,718 THE PROGRAM'S OUT COME 1091 00:38:05,718 --> 00:38:07,120 DEMONSTRATES ITS EFFECTIVENESS 1092 00:38:07,120 --> 00:38:11,224 IN SUPPORTING SERCA AWARDEES IN 1093 00:38:11,224 --> 00:38:15,161 THEIR RESEARCH CAREERS. 1094 00:38:15,161 --> 00:38:17,130 FOR THIS CONCEPT CLEARANCE TO 1095 00:38:17,130 --> 00:38:18,898 ADDRESS THE NEED FOR ONGOING 1096 00:38:18,898 --> 00:38:20,533 TRANSITION SUPPORT BETWEEN 1097 00:38:20,533 --> 00:38:22,502 KO1 AND R01 REPORT FOR 1098 00:38:22,502 --> 00:38:25,505 VETERINARY SCIENTISTS, REQUEST 1099 00:38:25,505 --> 00:38:26,940 FOR ISSUE OF A SMALL GRANT 1100 00:38:26,940 --> 00:38:29,108 PROGRAM FOR ORIP VETERINARY 1101 00:38:29,108 --> 00:38:31,945 SCIENTISTS K01 RECIPIENTS USING 1102 00:38:31,945 --> 00:38:36,149 THE R03 MECHANISM. 1103 00:38:36,149 --> 00:38:37,550 I'M HAPPY TO ANSWER ANY 1104 00:38:37,550 --> 00:38:39,218 QUESTIONS DURING THE DISCUSSION. 1105 00:38:39,218 --> 00:38:39,752 THANK YOU SO MUCH. 1106 00:38:39,752 --> 00:38:41,421 >> THANK YOU, RITESH. 1107 00:38:41,421 --> 00:38:42,188 DR. SANCHEZ, WOULD YOU PLEASE 1108 00:38:42,188 --> 00:38:42,956 SHARE ANY COMMENTS WITH THE 1109 00:38:42,956 --> 00:38:50,196 COUNCIL? 1110 00:38:50,196 --> 00:38:53,933 >> THANK YOU VERY MUCH, 1111 00:38:53,933 --> 00:38:54,267 DR. TANDON. 1112 00:38:54,267 --> 00:38:55,468 I HOPE EVERYBODY CAN HEAR ME. 1113 00:38:55,468 --> 00:38:58,438 IS THAT CORRECT? 1114 00:38:58,438 --> 00:39:00,440 >> YES, WE CAN. 1115 00:39:00,440 --> 00:39:01,307 >> EXCELLENT. 1116 00:39:01,307 --> 00:39:02,342 SO THE NATIONAL INSTITUTE OF 1117 00:39:02,342 --> 00:39:03,576 HEALTH HAS ALWAYS EMPHASIZED 1118 00:39:03,576 --> 00:39:05,111 DEVELOPING A ROBUST PHYSICIAN 1119 00:39:05,111 --> 00:39:06,446 SCIENTIST WORKFORCE, INCLUDING 1120 00:39:06,446 --> 00:39:07,880 VETERINARY SCIENTISTS. 1121 00:39:07,880 --> 00:39:11,351 THIS RECOGNITION ARISES FROM 1122 00:39:11,351 --> 00:39:12,485 VETERINARIANS' CRUCIAL ROLE IN 1123 00:39:12,485 --> 00:39:14,253 BIOMEDICAL RESEARCH AND THEIR 1124 00:39:14,253 --> 00:39:15,221 UNIQUE CONTRIBUTIONS TO 1125 00:39:15,221 --> 00:39:16,856 COMPARATIVE MEDICINE. 1126 00:39:16,856 --> 00:39:19,092 PROPORTION OF RESEARCH AWARD USE 1127 00:39:19,092 --> 00:39:19,959 ANIMALS. 1128 00:39:19,959 --> 00:39:21,294 VETERINARIANS ARE UNIQUELY 1129 00:39:21,294 --> 00:39:22,962 POSITIONED TO REFINE, REDUCE AND 1130 00:39:22,962 --> 00:39:25,465 IMPROVE THESE MODELS, AND YET 1131 00:39:25,465 --> 00:39:27,000 THERE ARE MINUSCULE PORTION OF 1132 00:39:27,000 --> 00:39:29,969 NIH FUNDED SCIENTISTS. 1133 00:39:29,969 --> 00:39:32,739 NIH HAS IMPLEMENTED VERY 1134 00:39:32,739 --> 00:39:33,506 STRINGENT CAREER DEVELOPMENT 1135 00:39:33,506 --> 00:39:35,575 PROGRAMS TO SUPPORT VETERINARY 1136 00:39:35,575 --> 00:39:37,010 SCIENTISTS AT DIFFERENT STAGES 1137 00:39:37,010 --> 00:39:37,844 OF THEIR CAREER. 1138 00:39:37,844 --> 00:39:39,145 THE OFFICE OF RESEARCH 1139 00:39:39,145 --> 00:39:41,014 INFRASTRUCTURE PROGRAMS SUPPORTS 1140 00:39:41,014 --> 00:39:42,882 THE SPECIAL EMPHASIS -- SERCA 1141 00:39:42,882 --> 00:39:44,717 THROUGH THE K01 MECHANISM. 1142 00:39:44,717 --> 00:39:46,686 THESE AWARDS AIM TO ENABLE THESE 1143 00:39:46,686 --> 00:39:47,787 INDIVIDUALS TO BECOME 1144 00:39:47,787 --> 00:39:48,921 COMPETITIVE FOR ACADEMIC 1145 00:39:48,921 --> 00:39:50,423 RESEARCH CAREERS AS 1146 00:39:50,423 --> 00:39:52,325 INDEPENDENTLY FUNDED BIOMEDICAL 1147 00:39:52,325 --> 00:39:52,759 SCIENTIST. 1148 00:39:52,759 --> 00:39:54,827 THESE AWARDS EMPHASIZE IN DEPTH 1149 00:39:54,827 --> 00:39:55,862 RESEARCH EXPERIENCE FOR UP TO 1150 00:39:55,862 --> 00:39:58,598 FOUR YEARS IN VARIOUS BASIC 1151 00:39:58,598 --> 00:40:01,334 PRE-CLINICAL AND TRANSLATIONAL 1152 00:40:01,334 --> 00:40:02,201 SCIENTIST SUPPLEMENTS. 1153 00:40:02,201 --> 00:40:03,736 THE FOCUS AREAS INCLUDE -- 1154 00:40:03,736 --> 00:40:05,638 ANIMAL MODELS THAT IDENTIFY, 1155 00:40:05,638 --> 00:40:08,141 DEVELOP AND CHARACTERIZE BOTH 1156 00:40:08,141 --> 00:40:09,375 SPONTANEOUS AND ENGINEERED 1157 00:40:09,375 --> 00:40:10,476 ANIMAL MODELS TO ENHANCE THE 1158 00:40:10,476 --> 00:40:12,979 UNDERSTANDING OF HUMAN DISEASES. 1159 00:40:12,979 --> 00:40:13,980 UNFORTUNATELY TRANSITION FROM A 1160 00:40:13,980 --> 00:40:16,849 TRAINING GRANT TO AN R01 AWARD 1161 00:40:16,849 --> 00:40:18,484 IS DIFFICULT AS OBTAINING 1162 00:40:18,484 --> 00:40:19,385 PRELIMINARY DATA IS ALSO LIMITED 1163 00:40:19,385 --> 00:40:23,356 TO THE LABORATORY FOR TRAINING. 1164 00:40:23,356 --> 00:40:24,791 TO BETTER PREPARE VETERINARY 1165 00:40:24,791 --> 00:40:26,526 SCIENTISTS TO REALIZE THEIR TRUE 1166 00:40:26,526 --> 00:40:27,360 INDEPENDENCE AND RECEIVE FUNDING 1167 00:40:27,360 --> 00:40:29,195 FOR THEIR RESEARCH AND TO 1168 00:40:29,195 --> 00:40:32,398 MAINTAIN THE LABORATORY, ORIP 1169 00:40:32,398 --> 00:40:34,967 HAS IN 2017 OFFERED A SMALL 1170 00:40:34,967 --> 00:40:36,703 GRANT PROGRAM, THE R01 AWARDS 1171 00:40:36,703 --> 00:40:38,471 FOR WHICH ONLY SERCA RECEIVED -- 1172 00:40:38,471 --> 00:40:41,007 CAN APPLY AFTER COMPLETING 24 1173 00:40:41,007 --> 00:40:42,975 MONTHS OF THE RESEARCH UNDER 1174 00:40:42,975 --> 00:40:43,943 THIS AWARD. 1175 00:40:43,943 --> 00:40:45,745 THE R01 DURATION IS ONLY TWO 1176 00:40:45,745 --> 00:40:47,080 YEARS AND FUNDING IS LIMITED TO 1177 00:40:47,080 --> 00:40:50,349 NO MORE THAN $150,000 OVER THIS 1178 00:40:50,349 --> 00:40:50,783 PERIOD. 1179 00:40:50,783 --> 00:40:52,251 THE SMALL GRANT AWARDS AIM TO 1180 00:40:52,251 --> 00:40:59,425 ENHANCE THE ABILITY OF VET NARAF 1181 00:40:59,425 --> 00:41:00,927 VETERINARY SCIENTISTS AS THEY 1182 00:41:00,927 --> 00:41:02,462 TRANSITION TO BECOMING FULLY 1183 00:41:02,462 --> 00:41:02,895 FLEDGED INDEPENDENT 1184 00:41:02,895 --> 00:41:03,463 INVESTIGATORS. 1185 00:41:03,463 --> 00:41:05,364 IT HELPS IMPROVE THEIR ABILITY 1186 00:41:05,364 --> 00:41:06,466 TO OBTAIN FURTHER FUNDING IN THE 1187 00:41:06,466 --> 00:41:09,402 FORM OF AN R01 OR EQUIVALENT. 1188 00:41:09,402 --> 00:41:11,304 IT IS ESSENTIAL TO EVALUATE 1189 00:41:11,304 --> 00:41:13,072 METRICS AND ASSESS THE SUCCESS 1190 00:41:13,072 --> 00:41:16,576 OF THE PROGRAM AS IT STANDS. 1191 00:41:16,576 --> 00:41:17,944 THE FUNDING OF THIS AWARD 1192 00:41:17,944 --> 00:41:19,345 THROUGH IMPLEMENTATION HAS BEEN 1193 00:41:19,345 --> 00:41:22,982 31% WHICH IS VERY GOOD, 1194 00:41:22,982 --> 00:41:24,217 R03 RECIPIENTS, THREE HAVE 1195 00:41:24,217 --> 00:41:26,753 OBTAINED ALREADY R01, WHICH IS 1196 00:41:26,753 --> 00:41:30,690 ALREADY A 23% SUCCESS RATE, AND 1197 00:41:30,690 --> 00:41:32,692 SEVERAL MORE HAVE R OH 1s 1198 00:41:32,692 --> 00:41:33,359 CURRENTLY UNDER REVIEW. 1199 00:41:33,359 --> 00:41:34,560 THIS IS A SIGNIFICANT 1200 00:41:34,560 --> 00:41:35,762 ACHIEVEMENT IN THE CURRENT 1201 00:41:35,762 --> 00:41:38,831 CLIMATE AND DESPITE THE 1202 00:41:38,831 --> 00:41:40,600 PANDEMIC. 1203 00:41:40,600 --> 00:41:43,803 IN ADDITION, THE NUMBER OF PUBL 1204 00:41:43,803 --> 00:41:46,305 PUBLICATIONS IS REASONABLE, 16, 1205 00:41:46,305 --> 00:41:48,207 WE ARE AWARE OF THE TIME IT 1206 00:41:48,207 --> 00:41:50,076 TAKES TO PRODUCE DATA AND THEN 1207 00:41:50,076 --> 00:41:51,511 WRITE WHILE AT THE SAME TIME 1208 00:41:51,511 --> 00:41:53,379 PREPARING AND WRITING YOUR NEXT 1209 00:41:53,379 --> 00:41:55,047 BIG GRANT, THE R01. 1210 00:41:55,047 --> 00:41:57,250 THE MANUSCRIPT TOPICS MESH 1211 00:41:57,250 --> 00:41:59,318 PERFECTLY WITH THOSE AWARDED BY 1212 00:41:59,318 --> 00:42:01,220 THOSE -- WITH THOSE AWARDS THEY 1213 00:42:01,220 --> 00:42:03,089 SUPPORT WHICH INCLUDE ANIMAL 1214 00:42:03,089 --> 00:42:06,125 ORIENTED AND MOLECULAR CELLULAR 1215 00:42:06,125 --> 00:42:06,959 RESEARCH. 1216 00:42:06,959 --> 00:42:08,394 -- ESSENTIAL IN BIOMEDICAL 1217 00:42:08,394 --> 00:42:08,728 RESEARCH. 1218 00:42:08,728 --> 00:42:10,463 THEY NOT ONLY BRING THE 1219 00:42:10,463 --> 00:42:12,431 SCIENTIFIC KNOW-HOW BUT ALSO 1220 00:42:12,431 --> 00:42:13,699 CONTRIBUTE WITH THEIR UNIQUE 1221 00:42:13,699 --> 00:42:15,201 EXPERTISE AND UNDERSTANDING OF 1222 00:42:15,201 --> 00:42:16,435 ANIMAL HEAL HEALTH AND WELFARE O 1223 00:42:16,435 --> 00:42:18,471 ENSURE THAT RESEARCH IS 1224 00:42:18,471 --> 00:42:20,873 CONDUCTED ETHICALLY AND 1225 00:42:20,873 --> 00:42:21,841 EFFECTIVELY, LEADING TO 1226 00:42:21,841 --> 00:42:25,244 ADVANCEMENTS IN HUMAN HEALTH. 1227 00:42:25,244 --> 00:42:26,579 IF WE EVER ENVISION A TIME WHERE 1228 00:42:26,579 --> 00:42:28,247 WE HAVE IN VITRO MODELS AND 1229 00:42:28,247 --> 00:42:29,215 COMPUTER PROGRAMMERS THAT 1230 00:42:29,215 --> 00:42:30,616 REPLACE THE USE OF LIVE ANIMALS 1231 00:42:30,616 --> 00:42:35,188 FOR OUR RESEARCH, VETERINARY 1232 00:42:35,188 --> 00:42:35,922 SCIENTISTS LIKE THIS THROUGH 1233 00:42:35,922 --> 00:42:37,023 THIS MECHANISM. 1234 00:42:37,023 --> 00:42:38,257 YOU FULLY SUPPORT THIS CONCEPT. 1235 00:42:38,257 --> 00:42:39,592 IF ANYTHING, THE NUMBER OF 1236 00:42:39,592 --> 00:42:40,993 AWARDS SHOULD BE INCREASED. 1237 00:42:40,993 --> 00:42:45,364 THANK YOU. 1238 00:42:45,364 --> 00:42:47,433 >> THANK YOU, SUSAN. 1239 00:42:47,433 --> 00:42:48,100 DR. GANDHI, WOULD YOU LIKE TO 1240 00:42:48,100 --> 00:42:50,303 ADD ANY COMMENTS? 1241 00:42:50,303 --> 00:42:51,571 >> YES. 1242 00:42:51,571 --> 00:42:53,706 SO I THINK THE SUPPORTIVE EARLY 1243 00:42:53,706 --> 00:42:55,474 STAGE INVESTIGATORS, ESPECIALLY 1244 00:42:55,474 --> 00:42:57,643 AT THIS POINT IN HISTORY WHERE 1245 00:42:57,643 --> 00:43:01,080 THERE'S A CONCERN ABOUT SUPPORT 1246 00:43:01,080 --> 00:43:02,081 OF EARLY STAGE INVESTIGATORS IS 1247 00:43:02,081 --> 00:43:02,849 THE MOST IMPORTANT THING WE 1248 00:43:02,849 --> 00:43:04,383 COULD BE DOING AT THE NIH. 1249 00:43:04,383 --> 00:43:05,852 SO I REALLY SUPPORT ANYTHING 1250 00:43:05,852 --> 00:43:09,455 THAT ALLOWS TRANSITION FROM K TO 1251 00:43:09,455 --> 00:43:10,122 R GRANTS. 1252 00:43:10,122 --> 00:43:11,657 THIS IS SOMEWHAT UNUSUAL IN THE 1253 00:43:11,657 --> 00:43:14,760 SENSE THAT R03s ARE AT OTHER 1254 00:43:14,760 --> 00:43:18,164 INSTITUTIONS, INCLUDING NHLBI, 1255 00:43:18,164 --> 00:43:20,499 NIAID AND NIAMS AND NIDDK, BUT 1256 00:43:20,499 --> 00:43:22,168 AT LEAST TO MY KNOWLEDGE AT 1257 00:43:22,168 --> 00:43:23,803 NIAID, IT ISN'T SPECIFICALLY A 1258 00:43:23,803 --> 00:43:25,071 BRIDGING MECHANISM FROM A K TO 1259 00:43:25,071 --> 00:43:25,605 AN R. 1260 00:43:25,605 --> 00:43:28,774 THESE ARE $150,000 GRANTS THAT 1261 00:43:28,774 --> 00:43:32,345 CAN BE AWARDED AND APPLIED FOR 1262 00:43:32,345 --> 00:43:33,980 OVER TWO YEARS. 1263 00:43:33,980 --> 00:43:35,948 AND THIS SEEMS TO BE VERY 1264 00:43:35,948 --> 00:43:37,683 SPECIFICALLY FOR THE 1265 00:43:37,683 --> 00:43:38,784 VETERINARIAN MEDICINE EARLY 1266 00:43:38,784 --> 00:43:42,121 STAGE INVESTIGATORS DURING THEIR 1267 00:43:42,121 --> 00:43:42,455 K AWARD. 1268 00:43:42,455 --> 00:43:43,856 I THINK IT'S IMPORTANT TO SAY 1269 00:43:43,856 --> 00:43:45,725 THAT THEY CAN APPLY EVEN MORE 1270 00:43:45,725 --> 00:43:48,794 THAN ONCE, AND AS LONG AS IT'S 1271 00:43:48,794 --> 00:43:50,596 NOT AT A NO-COST EXTENSION, THE 1272 00:43:50,596 --> 00:43:52,798 APPLICATION CAN OCCUR IN THAT 1273 00:43:52,798 --> 00:43:53,866 TIME PERIOD WHERE USUALLY 1274 00:43:53,866 --> 00:43:57,003 THERE'S A PREPARATION FOR K TO 1275 00:43:57,003 --> 00:43:57,703 R. 1276 00:43:57,703 --> 00:43:59,105 THIS DOES HAVE A HIGH SUCCESS 1277 00:43:59,105 --> 00:43:59,305 RATE. 1278 00:43:59,305 --> 00:44:01,173 THESE ARE, QUOTE, LOW HANGING 1279 00:44:01,173 --> 00:44:06,379 FRUITS OR AT LEAST USUALLY 1280 00:44:06,379 --> 00:44:07,680 EASIER TO GET IN TERMS OF THE 1281 00:44:07,680 --> 00:44:10,082 FUNDING PAYLINES FOR R03s 1282 00:44:10,082 --> 00:44:11,684 VERSUS R01s, FOR EXAMPLE, BUT 1283 00:44:11,684 --> 00:44:14,420 I THINK ALSO IMPORTANTLY WHAT'S 1284 00:44:14,420 --> 00:44:15,621 INCLUDED HERE IN THE 1285 00:44:15,621 --> 00:44:19,492 MODIFICATION OF THIS R03 PROGRAM 1286 00:44:19,492 --> 00:44:23,029 IS A THREE TIMES YEARLY 1287 00:44:23,029 --> 00:44:23,562 APPLICATION PROCESS. 1288 00:44:23,562 --> 00:44:24,997 POSSIBILITY WHERE IT USED TO BE 1289 00:44:24,997 --> 00:44:27,366 WHERE IT WAS ONLY POSSIBLE TO 1290 00:44:27,366 --> 00:44:28,334 APPLY TO THESE ONCE YEARLY. 1291 00:44:28,334 --> 00:44:31,604 SO I THINK THAT'S A REALLY 1292 00:44:31,604 --> 00:44:37,510 STRONG MODIFICATION TO THE ORIP 1293 00:44:37,510 --> 00:44:39,445 SERCA K01 AWARDEE OPPORTUNITY 1294 00:44:39,445 --> 00:44:43,049 PRESENTED HERE, AND AGAIN, I 1295 00:44:43,049 --> 00:44:44,917 THINK IT'S TIME CERTAINLY AS WE 1296 00:44:44,917 --> 00:44:47,253 LOOK ACROSS THE UNIVERSITIES, WE 1297 00:44:47,253 --> 00:44:48,788 DEFINITELY WANT TO SUPPORT OUR 1298 00:44:48,788 --> 00:44:49,922 EARLY STAGE INVESTIGATORS, THIS 1299 00:44:49,922 --> 00:44:52,558 IS THE TIME TO PUT OUT AS MANY 1300 00:44:52,558 --> 00:44:53,793 INITIATIVES AS WE CAN TO 1301 00:44:53,793 --> 00:44:56,295 ENCOURAGE PEOPLE TO GO INTO NIH 1302 00:44:56,295 --> 00:44:56,662 FUNDED RESEARCH. 1303 00:44:56,662 --> 00:45:03,302 THANK YOU. 1304 00:45:03,302 --> 00:45:04,670 >> THANK YOU VERY MUCH, MONICA. 1305 00:45:04,670 --> 00:45:06,005 IF COUNCILMEMBERS HAVE ANY 1306 00:45:06,005 --> 00:45:06,973 QUESTIONS OR COMMENTS, PLEASE 1307 00:45:06,973 --> 00:45:09,475 RAISE YOUR HAND AND YOU'LL BE 1308 00:45:09,475 --> 00:45:16,415 RECOGNIZED BY FRAN SI K FRANZISE 1309 00:45:16,415 --> 00:45:16,949 AND UNMUTE YOURSELF. 1310 00:45:16,949 --> 00:45:18,351 >> I THINK WE HAVE THE FIRST 1311 00:45:18,351 --> 00:45:18,884 QUESTION. 1312 00:45:18,884 --> 00:45:19,919 RAFAEL HAS THE FIRST QUESTION. 1313 00:45:19,919 --> 00:45:21,954 >> NOT A QUESTION, JUST A 1314 00:45:21,954 --> 00:45:28,961 COMMENT TO SUPPORT THIS IC IN MY 1315 00:45:28,961 --> 00:45:30,262 INSTITUTION -- 1316 00:45:30,262 --> 00:45:30,596 [INTERRUPTION] 1317 00:45:30,596 --> 00:45:32,098 >> I'M UNMUTED. 1318 00:45:32,098 --> 00:45:34,934 >> I THINK WE HAVE THE FIRST 1319 00:45:34,934 --> 00:45:36,102 QUESTION -- 1320 00:45:36,102 --> 00:45:45,111 [ECHOING] 1321 00:45:45,111 --> 00:45:46,812 >> RAFAEL, WE CAN HEAR YOU AND 1322 00:45:46,812 --> 00:45:48,214 WE HAD THIS WEIRD ECHO. 1323 00:45:48,214 --> 00:45:49,548 I COULD RECOGNIZE MY VOICE BUT 1324 00:45:49,548 --> 00:45:50,649 IT SOUNDED LIKE -- 1325 00:45:50,649 --> 00:45:52,585 >> IT'S A PLAYBACK OF THE 1326 00:45:52,585 --> 00:45:52,818 LAST -- 1327 00:45:52,818 --> 00:45:53,152 >> ALL RIGHT. 1328 00:45:53,152 --> 00:45:55,421 SO WE ARE GOOD, RAFAEL. 1329 00:45:55,421 --> 00:45:56,122 PLEASE, YOUR COMMENT. 1330 00:45:56,122 --> 00:45:58,124 >> YEAH, I JUST WANT TO VERY 1331 00:45:58,124 --> 00:46:01,293 BRIEFLY LEND MY SUPPORT TO THIS 1332 00:46:01,293 --> 00:46:01,694 PROPOSAL. 1333 00:46:01,694 --> 00:46:03,029 I SEE THIS IN MY INSTITUTION 1334 00:46:03,029 --> 00:46:04,964 WHERE THIS PERIOD IS VERY 1335 00:46:04,964 --> 00:46:06,932 DIFFICULT FOR OUR INVESTIGATORS 1336 00:46:06,932 --> 00:46:09,335 TO MANAGE SOMETIMES BECAUSE 1337 00:46:09,335 --> 00:46:11,170 THERE REALLY IS NO CLEAR 1338 00:46:11,170 --> 00:46:12,838 MECHANISM OF HOW TO CONTINUE TO 1339 00:46:12,838 --> 00:46:17,810 BE FUNDED, SO I JUST WANTED TO 1340 00:46:17,810 --> 00:46:19,045 AGREE WITH THE TWO DISCUSSANTS 1341 00:46:19,045 --> 00:46:21,781 THAT IT'S A VERY IMPORTANT THING 1342 00:46:21,781 --> 00:46:22,515 TO CONTINUE TO SUPPORT. 1343 00:46:22,515 --> 00:46:26,218 THANK YOU. 1344 00:46:26,218 --> 00:46:32,525 >> THANK YOU. 1345 00:46:32,525 --> 00:46:34,527 ARE THERE ANY OTHER COMMENTS OR 1346 00:46:34,527 --> 00:46:44,870 POSSIBLY QUESTIONS? 1347 00:46:45,771 --> 00:46:46,172 ALL RIGHT. 1348 00:46:46,172 --> 00:46:52,611 I THINK WE CAN MOVE ON. 1349 00:46:52,611 --> 00:46:53,913 IF THERE ARE NO OTHER COMMENTS, 1350 00:46:53,913 --> 00:46:57,216 YOU ALL HEARD THE MOTION FOR A 1351 00:46:57,216 --> 00:46:59,585 VOTE ON THIS CONCEPT. 1352 00:46:59,585 --> 00:47:04,590 I THINK BETINA WILL TYPE IT INTO 1353 00:47:04,590 --> 00:47:05,791 CHAT AND I WILL CALL FOR THE 1354 00:47:05,791 --> 00:47:06,125 VOTE. 1355 00:47:06,125 --> 00:47:08,694 MAY I HAVE A MOTION FOR APPROVAL 1356 00:47:08,694 --> 00:47:11,230 OF THE ORIP CONCEPT CLEARANCE 1357 00:47:11,230 --> 00:47:12,331 ENTITLED LIMITED COMPETITION 1358 00:47:12,331 --> 00:47:14,300 SMALL GRANT PROGRAM FOR ORIP 1359 00:47:14,300 --> 00:47:17,470 SPECIAL EMPHASIS AWARD CAREER -- 1360 00:47:17,470 --> 00:47:19,805 I'M SORRY -- SPECIAL EMPHASIS 1361 00:47:19,805 --> 00:47:24,076 RESEARCH CAREER AWARD, SERCA, 1362 00:47:24,076 --> 00:47:25,644 K01 RECIPIENTS FOR AN R03. 1363 00:47:25,644 --> 00:47:26,679 IS THERE SUCH A MOTION? 1364 00:47:26,679 --> 00:47:27,780 I SEE SO MOVED. 1365 00:47:27,780 --> 00:47:29,081 I SEE SECOND. 1366 00:47:29,081 --> 00:47:30,749 DON'T EVEN NEED TO ASK FOR THIS 1367 00:47:30,749 --> 00:47:31,217 AT THIS POINT. 1368 00:47:31,217 --> 00:47:34,720 I WILL ASK, IS THERE ANY 1369 00:47:34,720 --> 00:47:41,560 ADDITIONAL DISCUSSION? 1370 00:47:41,560 --> 00:47:43,362 I DON'T SEE ANY HANDS, AND I DO 1371 00:47:43,362 --> 00:47:44,830 NOT SEE ANY COMMENTS IN THE 1372 00:47:44,830 --> 00:47:48,167 CHAT. 1373 00:47:48,167 --> 00:47:49,368 IN THAT CASE, I WILL TURN THE 1374 00:47:49,368 --> 00:47:51,837 VOTE OVER TO CHRISTINA SO SHE 1375 00:47:51,837 --> 00:47:53,272 CAN CONDUCT THE VOTE. 1376 00:47:53,272 --> 00:47:53,739 CHRISTINA? 1377 00:47:53,739 --> 00:47:56,675 >> THANK YOU, DR. GRIEDER. 1378 00:47:56,675 --> 00:47:57,843 THE POLL SHOULD AUTOMATICALLY 1379 00:47:57,843 --> 00:47:59,578 APPEAR ON YOUR SCREEN WHEN IT IS 1380 00:47:59,578 --> 00:48:00,012 LAUNCHED. 1381 00:48:00,012 --> 00:48:02,214 PLEASE REMEMBER TO HIT SUBMIT 1382 00:48:02,214 --> 00:48:03,282 AFTER YOU'VE SELECTED YOUR VOTE. 1383 00:48:03,282 --> 00:48:04,884 THE VOTE WILL ONLY COUNT AFTER 1384 00:48:04,884 --> 00:48:06,085 YOU HIT SUBMIT. 1385 00:48:06,085 --> 00:48:08,387 AS A REMINDER, ONLY 1386 00:48:08,387 --> 00:48:08,854 COUNCILMEMBERS SHOULD 1387 00:48:08,854 --> 00:48:12,057 PARTICIPATE IN THE POLL. 1388 00:48:12,057 --> 00:48:22,501 THE POLL IS STARTING NOW. 1389 00:48:26,372 --> 00:48:28,374 >> WE'RE NOT GETTING ANYTHING. 1390 00:48:28,374 --> 00:48:31,143 AT LEAST NOT ME. 1391 00:48:31,143 --> 00:48:32,778 >> IS EVERYBODY -- 1392 00:48:32,778 --> 00:48:34,380 >> WE'RE NOT GETTING -- 1393 00:48:34,380 --> 00:48:35,614 >> YES, WE'RE ALL HAVING 1394 00:48:35,614 --> 00:48:36,715 PROBLEMS GETTING THE POLL. 1395 00:48:36,715 --> 00:48:38,551 >> THERE'S A SECOND WINDOW THAT 1396 00:48:38,551 --> 00:48:39,985 POPS UP, SO YOU MIGHT HAVE TO 1397 00:48:39,985 --> 00:48:41,587 JUST MAKE SURE YOU'RE SEEING ALL 1398 00:48:41,587 --> 00:48:43,656 THE WINDOWS. 1399 00:48:43,656 --> 00:48:47,059 >> I SAW IT. 1400 00:48:47,059 --> 00:48:50,229 >> OR IF YOU OPEN YOUR CHAT, IT 1401 00:48:50,229 --> 00:48:51,363 ALSO POPS UP IN YOUR CHAT 1402 00:48:51,363 --> 00:48:58,204 WINDOW. 1403 00:48:58,204 --> 00:48:59,271 >> IT'S IN THE CHAT. 1404 00:48:59,271 --> 00:49:00,773 >> THE POLL SHOULD APPEAR EITHER 1405 00:49:00,773 --> 00:49:03,809 ON YOUR SCREEN AS A POP-UP OR IT 1406 00:49:03,809 --> 00:49:12,585 WILL APPEAR IN THE CHAT. 1407 00:49:12,585 --> 00:49:14,086 >> IT'S IN THE CHAT BUT IT SAYS 1408 00:49:14,086 --> 00:49:16,121 THE BUTTON IS DISABLED, CONTACT 1409 00:49:16,121 --> 00:49:17,323 YOUR IT ADMIN FOR MORE 1410 00:49:17,323 --> 00:49:17,623 INFORMATION. 1411 00:49:17,623 --> 00:49:21,060 >> IT SAYS THIS BOT IS DISABLED. 1412 00:49:21,060 --> 00:49:21,894 THAT'S WHAT MINE SAYS. 1413 00:49:21,894 --> 00:49:23,662 >> I WOULD ASSUME IN THE CHAT, 1414 00:49:23,662 --> 00:49:24,296 THEY CAN'T VOTE. 1415 00:49:24,296 --> 00:49:25,764 THEY HAVE TO HAVE THE POP-UP 1416 00:49:25,764 --> 00:49:26,232 WINDOW. 1417 00:49:26,232 --> 00:49:27,967 IN MY SCREEN, THE POP-UP WINDOW 1418 00:49:27,967 --> 00:49:29,401 IS IN FRONT OF THE TEAMS 1419 00:49:29,401 --> 00:49:31,537 MEETING, AND FOR YOU AS WAS 1420 00:49:31,537 --> 00:49:34,940 DISCUSSED, IT MAY BE BEHIND. 1421 00:49:34,940 --> 00:49:37,676 >> AND AS A REMINDER, ONLY 1422 00:49:37,676 --> 00:49:38,410 COUNCILMEMBERS SHOULD 1423 00:49:38,410 --> 00:49:38,711 PARTICIPATE. 1424 00:49:38,711 --> 00:49:41,046 >> WE ALREADY HAVE 12 VOTES. 1425 00:49:41,046 --> 00:49:43,315 >> IT SAID IN MINE THAT 1426 00:49:43,315 --> 00:49:43,916 SOMETHING WENT WRONG IN THE 1427 00:49:43,916 --> 00:49:44,416 VOTE. 1428 00:49:44,416 --> 00:49:46,452 I DID HIT APPROVE AND SUBMITTED 1429 00:49:46,452 --> 00:49:47,553 BUT IT SAID SOMETHING WENT 1430 00:49:47,553 --> 00:49:51,490 WRONG. 1431 00:49:51,490 --> 00:49:53,225 THIS IS BARBARA TALKING. 1432 00:49:53,225 --> 00:49:54,159 I TRIED TO VOTE. 1433 00:49:54,159 --> 00:49:56,161 >> SO LET'S TRY SOMETHING. 1434 00:49:56,161 --> 00:49:58,063 LET'S ABANDON THIS WHOLE VOTE 1435 00:49:58,063 --> 00:49:59,098 AND START OVER. 1436 00:49:59,098 --> 00:50:00,833 BECAUSE WE ARE ACTUALLY SEEING 1437 00:50:00,833 --> 00:50:04,403 12 VOTES SO 12 OF YOU DID VOTE. 1438 00:50:04,403 --> 00:50:07,039 ALSO I NEED TO REMIND YOU DON'T 1439 00:50:07,039 --> 00:50:07,873 VOTE TWICE. 1440 00:50:07,873 --> 00:50:09,174 ONLY VOTE ONCE. 1441 00:50:09,174 --> 00:50:10,709 BUT SO CHRISTINA WILL START 1442 00:50:10,709 --> 00:50:11,043 OVER. 1443 00:50:11,043 --> 00:50:15,214 SHE WILL SAY HER SAME LITTLE 1444 00:50:15,214 --> 00:50:16,782 THING AGAIN ABOUT THE VOTE. 1445 00:50:16,782 --> 00:50:18,317 SO PLEASE LET'S START OVER. 1446 00:50:18,317 --> 00:50:22,388 >> THE POLL IS CLOSING. 1447 00:50:22,388 --> 00:50:26,759 >> THE OLD POLL IS CLOSING. 1448 00:50:26,759 --> 00:50:28,494 >> WE WILL OPEN UP A NEW POLL. 1449 00:50:28,494 --> 00:50:29,928 THIS POLL WILL HAVE A NUMBER 1450 00:50:29,928 --> 00:50:30,462 2 NEXT TO IT. 1451 00:50:30,462 --> 00:50:31,730 IT SHOULD APPEAR ON YOUR SCREEN 1452 00:50:31,730 --> 00:50:32,731 WHEN IT IS LAUNCHED. 1453 00:50:32,731 --> 00:50:33,866 PLEASE REMEMBER TO HIT SUBMIT IN 1454 00:50:33,866 --> 00:50:44,376 ORDER FOR YOUR VOTE TO COUNT. 1455 00:50:55,354 --> 00:50:56,855 >> CHRISTINA, THIS TIME I CAN'T 1456 00:50:56,855 --> 00:50:57,189 SEE IT. 1457 00:50:57,189 --> 00:50:58,290 NOT THAT I CAN VOTE BUT THIS 1458 00:50:58,290 --> 00:51:00,125 TIME I COULD NOT SEE IT, OR I 1459 00:51:00,125 --> 00:51:02,661 CAN'T SEE IT. 1460 00:51:02,661 --> 00:51:04,663 >> NOR COULD I, AND I VOTED THE 1461 00:51:04,663 --> 00:51:04,963 FIRST TIME. 1462 00:51:04,963 --> 00:51:05,664 >> ONE MOMENT. 1463 00:51:05,664 --> 00:51:07,199 WE ARE JUST ABOUT TO LAUNCH IT 1464 00:51:07,199 --> 00:51:08,500 AND IT SHOULD LAUNCH NOW. 1465 00:51:08,500 --> 00:51:09,068 >> ALL RIGHT. 1466 00:51:09,068 --> 00:51:11,003 SO NOW I CAN SEE IT, I HOPE 1467 00:51:11,003 --> 00:51:12,438 EVERYBODY ELSE CAN SEE IT AS 1468 00:51:12,438 --> 00:51:12,638 WELL. 1469 00:51:12,638 --> 00:51:17,276 >> YES. 1470 00:51:17,276 --> 00:51:19,478 >> THANK YOU FOR YOUR PATIENCE. 1471 00:51:19,478 --> 00:51:20,846 >> DID THOSE WHO -- 1472 00:51:20,846 --> 00:51:21,914 >> I CAN ONLY SEE IT IN THE 1473 00:51:21,914 --> 00:51:22,481 CHAT. 1474 00:51:22,481 --> 00:51:24,316 >> AND DO YOU STILL HAVE THE 1475 00:51:24,316 --> 00:51:25,384 BLOCKING THAT IT SAYS YOUR 1476 00:51:25,384 --> 00:51:26,485 ORGANIZATION IS NOT ALLOWING 1477 00:51:26,485 --> 00:51:32,591 THIS BOT? 1478 00:51:32,591 --> 00:51:33,792 I SEE YOU'RE SHAKING YOUR HEAD. 1479 00:51:33,792 --> 00:51:35,461 >> IT SAYS THE BOT IS DISABLED. 1480 00:51:35,461 --> 00:51:37,930 >> I THINK THAT MIGHT BE YOUR 1481 00:51:37,930 --> 00:51:39,131 UNIVERSITY'S, ON YOUR END THAT 1482 00:51:39,131 --> 00:51:40,632 THEY'RE NOT ALLOWING THAT TO 1483 00:51:40,632 --> 00:51:40,833 OCCUR. 1484 00:51:40,833 --> 00:51:46,672 >> OKAY. 1485 00:51:46,672 --> 00:51:47,639 >> THIS IS BARBARA. 1486 00:51:47,639 --> 00:51:49,608 I'M GOING TO LOG IN IN A 1487 00:51:49,608 --> 00:51:51,143 DIFFERENT DEVICE. 1488 00:51:51,143 --> 00:51:52,344 I VOTE BUT IT SAID SOMETHING 1489 00:51:52,344 --> 00:51:53,412 WENT WRONG WITH THE VOTE SO I'M 1490 00:51:53,412 --> 00:51:59,351 GOING TO TRY A DIFFERENT DEVICE. 1491 00:51:59,351 --> 00:52:01,387 >> SO LET ME ASK, HOW MANY 1492 00:52:01,387 --> 00:52:03,689 PEOPLE HAD THE BLOCK FROM THEIR 1493 00:52:03,689 --> 00:52:05,124 INSTITUTION OR FROM SOMEWHERE 1494 00:52:05,124 --> 00:52:06,291 ELSE? 1495 00:52:06,291 --> 00:52:08,527 I SEE NINE RESPONSES AT THIS 1496 00:52:08,527 --> 00:52:12,264 POINT. 1497 00:52:12,264 --> 00:52:13,465 THEN BARBARA SAID SHE WOULD LOG 1498 00:52:13,465 --> 00:52:14,566 IN IN A DIFFERENT WAY. 1499 00:52:14,566 --> 00:52:24,042 I SAW ONE HAND UP. 1500 00:52:24,042 --> 00:52:24,910 BARBARA, MONICA. 1501 00:52:24,910 --> 00:52:32,284 YEP. 1502 00:52:32,284 --> 00:52:33,786 >> I DON'T KNOW IF WE WANT TO 1503 00:52:33,786 --> 00:52:35,154 DISCUSS THIS NOW BUT I JUST 1504 00:52:35,154 --> 00:52:36,155 OPENED TEAMS INSTEAD OF THE 1505 00:52:36,155 --> 00:52:38,223 BROWSER AND IT ASKED ME DO YOU 1506 00:52:38,223 --> 00:52:39,625 ALLOW WINDOWS TO POP UP AND I 1507 00:52:39,625 --> 00:52:40,159 SAID YES. 1508 00:52:40,159 --> 00:52:41,160 SO MAYBE THE NEXT TIME AROUND 1509 00:52:41,160 --> 00:52:43,695 I'LL BE ABLE TO SEE IT. 1510 00:52:43,695 --> 00:52:47,566 >> SO THE OTHER VERSION THAT WE 1511 00:52:47,566 --> 00:52:50,202 CAN DO, WE CAN JUST VOTE BY 1512 00:52:50,202 --> 00:52:51,837 RAISED HANDS FOR THIS CONCEPT 1513 00:52:51,837 --> 00:52:55,774 AND THEN MAYBE TRY AGAIN FOR THE 1514 00:52:55,774 --> 00:52:57,276 NEXT CONCEPT, WHEN PEOPLE 1515 00:52:57,276 --> 00:52:57,709 CORRECT IT. 1516 00:52:57,709 --> 00:53:00,679 WILL THAT WORK FOR EVERYBODY? 1517 00:53:00,679 --> 00:53:04,183 SO WE COULD JUST ASK ALL THOSE 1518 00:53:04,183 --> 00:53:06,585 IN FAVOR AND THEN YOU RAISE 1519 00:53:06,585 --> 00:53:08,220 YOUR -- ACTUALLY WE SHOULD GIVE 1520 00:53:08,220 --> 00:53:08,554 INSTRUCTIONS. 1521 00:53:08,554 --> 00:53:11,023 IF YOU COULD RAISE YOUR VIRTUAL 1522 00:53:11,023 --> 00:53:12,324 HANDS, THAT WOULD BE INCREDIBLY 1523 00:53:12,324 --> 00:53:13,425 HELPFUL. 1524 00:53:13,425 --> 00:53:17,596 SO WE HAVE AT THIS POINT DICK 1525 00:53:17,596 --> 00:53:18,564 AND -- OKAY, SO NOW THE HANDS 1526 00:53:18,564 --> 00:53:19,131 COME UP. 1527 00:53:19,131 --> 00:53:21,400 I LIKE IT. 1528 00:53:21,400 --> 00:53:26,004 SO WE HAVE AT THIS POINT RAISED 1529 00:53:26,004 --> 00:53:27,172 HANDS FOR THOSE IN FAVOR. 1530 00:53:27,172 --> 00:53:30,375 THEN I WILL ASK THROWS AGAINST T 1531 00:53:30,375 --> 00:53:31,543 AND THEN THOSE ABSTAINED. 1532 00:53:31,543 --> 00:53:32,478 ALL RIGHT. 1533 00:53:32,478 --> 00:53:35,514 I SEE 14 HANDS UP. 1534 00:53:35,514 --> 00:53:40,786 AND I COUNT THOSE -- DO I SEE 14 1535 00:53:40,786 --> 00:53:43,922 OR DO I SEE 13? 1536 00:53:43,922 --> 00:53:51,096 15 NOW? 1537 00:53:51,096 --> 00:53:53,065 CAN YOU ALL SEE HOW MANY HANDS? 1538 00:53:53,065 --> 00:53:54,733 I WANT TO RELY ON SOMEBODY WHO 1539 00:53:54,733 --> 00:54:02,508 COUNTS BETTER THAN ME. 1540 00:54:02,508 --> 00:54:04,209 >> THERE ARE 15 RAISED HANDS. 1541 00:54:04,209 --> 00:54:06,178 >> 15 RAISED HANDS, I COUNT 1542 00:54:06,178 --> 00:54:07,813 THOSE AS YES. 1543 00:54:07,813 --> 00:54:09,615 WOULD YOU BE ABLE TO TAKE YOUR 1544 00:54:09,615 --> 00:54:10,849 HANDS DOWN AT THIS POINT AND 1545 00:54:10,849 --> 00:54:15,654 THEN I ASK FOR THE NO'S. 1546 00:54:15,654 --> 00:54:16,188 ALL HANDS DOWN. 1547 00:54:16,188 --> 00:54:18,123 THIS SEEMS LIKE VERY INEFFICIENT 1548 00:54:18,123 --> 00:54:19,892 WAY TO DO IT, BUT -- ALL RIGHT. 1549 00:54:19,892 --> 00:54:20,959 ALL HANDS DOWN, GOOD. 1550 00:54:20,959 --> 00:54:23,362 SO NOW I ASK ALL THOSE WHO ARE 1551 00:54:23,362 --> 00:54:24,329 AGAINST THIS CONCEPT, PLEASE 1552 00:54:24,329 --> 00:54:28,700 VOTE. 1553 00:54:28,700 --> 00:54:30,135 NOT SEEING ANYBODY, I'M MOVING 1554 00:54:30,135 --> 00:54:30,536 ALONG. 1555 00:54:30,536 --> 00:54:33,372 ANY AB SENGSES? 1556 00:54:33,372 --> 00:54:34,673 -- ANY ABSTENTIONS? 1557 00:54:34,673 --> 00:54:36,875 NOT SEEING ANYBODY. 1558 00:54:36,875 --> 00:54:39,177 WE GO WITH THE 15 YESES. 1559 00:54:39,177 --> 00:54:40,279 THANK YOU VERY MUCH FOR THOSE 1560 00:54:40,279 --> 00:54:40,579 VOTES. 1561 00:54:40,579 --> 00:54:44,116 LET'S HOPE THE NEXT ONE, WE CAN 1562 00:54:44,116 --> 00:54:45,384 DO A LITTLE BIT MORE SMOOTHLY. 1563 00:54:45,384 --> 00:54:49,321 WITH THAT, BACK TO YOU, NICOLE. 1564 00:54:49,321 --> 00:54:50,722 >> OKAY, THANK YOU. 1565 00:54:50,722 --> 00:54:52,891 JUST TO CLARIFY, THE MOTION AS 1566 00:54:52,891 --> 00:54:55,060 STATED HAS PASSED. 1567 00:54:55,060 --> 00:54:56,495 SO OUR NEXT CONCEPT CLEARANCE 1568 00:54:56,495 --> 00:54:58,497 FOR TODAY IS A REISSUE FOR THE 1569 00:54:58,497 --> 00:55:02,067 OFFICE OF STRATEGIC 1570 00:55:02,067 --> 00:55:03,068 COORDINATION. 1571 00:55:03,068 --> 00:55:04,937 DRS. TRISH LABOSKY AND BECKY 1572 00:55:04,937 --> 00:55:07,172 MILLER, PROGRAM LEADERS IN OSC, 1573 00:55:07,172 --> 00:55:09,608 WILL PRESENT ON THE CONCEPT 1574 00:55:09,608 --> 00:55:11,243 ENTITLED HIGH RISK HIGH REWARD 1575 00:55:11,243 --> 00:55:12,978 OR HRHR RESEARCH PROGRAM. 1576 00:55:12,978 --> 00:55:14,079 THE PRESENTATION WILL BE 1577 00:55:14,079 --> 00:55:15,514 FOLLOWED BY COMMENTS FROM TWO 1578 00:55:15,514 --> 00:55:17,249 ASSIGNED COUNCILMEMBER 1579 00:55:17,249 --> 00:55:18,150 DISCUSSANTS, DR. JENNIFER MANLY 1580 00:55:18,150 --> 00:55:19,885 AND DR. MONICA GANDHI. 1581 00:55:19,885 --> 00:55:21,086 FOLLOWING THE VOTE, WE WILL MOVE 1582 00:55:21,086 --> 00:55:23,922 ON TO A PRESENTATION BY OSC 1583 00:55:23,922 --> 00:55:26,191 DIRECTOR DR. CAROLYN HUTTER TO 1584 00:55:26,191 --> 00:55:27,292 DISCUSS A NEW COUNCIL OF 1585 00:55:27,292 --> 00:55:32,097 COUNCILS WORKING GROUP ON HRHR. 1586 00:55:32,097 --> 00:55:33,732 OVER TO YOU, TRISH AND BECKY. 1587 00:55:33,732 --> 00:55:34,366 >> THANKS. 1588 00:55:34,366 --> 00:55:34,933 GOOD MORNING. 1589 00:55:34,933 --> 00:55:36,902 CAN EVERYBODY HEAR ME? 1590 00:55:36,902 --> 00:55:37,836 >> YES, WE CAN. 1591 00:55:37,836 --> 00:55:38,604 >> OH, GOOD. 1592 00:55:38,604 --> 00:55:40,672 ALL RIGHT. 1593 00:55:40,672 --> 00:55:42,441 SO GOOD MORNING, AND I'M HERE TO 1594 00:55:42,441 --> 00:55:46,778 TALK TO YOU BRIEFLY ABOUT THE 1595 00:55:46,778 --> 00:55:47,112 RENEWAL. 1596 00:55:47,112 --> 00:55:48,547 WE'VE HAD THIS PROGRAM GOING ON 1597 00:55:48,547 --> 00:55:51,450 FOR A WHILE, BUT THE REKNEEL OF 1598 00:55:51,450 --> 00:55:53,085 THESE FOUR HIGH RISK, HIGH 1599 00:55:53,085 --> 00:55:54,620 REWARD NOTICES OF FUNDING 1600 00:55:54,620 --> 00:55:55,721 OPPORTUNITIES. 1601 00:55:55,721 --> 00:56:00,826 SO ON THE NEXT SLIDE, THIS -- I 1602 00:56:00,826 --> 00:56:02,260 CAN'T ADVANCE THE SLIDES, AND I 1603 00:56:02,260 --> 00:56:05,864 ALSO CAN'T SEE THE BOTTOM LINE, 1604 00:56:05,864 --> 00:56:07,566 BUT THAT MIGHT BE MY SCREEN. 1605 00:56:07,566 --> 00:56:08,367 ANYWAY. 1606 00:56:08,367 --> 00:56:10,335 SO WE'RE HERE TODAY TO TALK 1607 00:56:10,335 --> 00:56:13,505 ABOUT THESE FOUR INITIATIVES 1608 00:56:13,505 --> 00:56:15,707 WITHIN THE NIH DIRECTOR'S HIGH 1609 00:56:15,707 --> 00:56:17,342 RISK HIGH REWARD RESEARCH 1610 00:56:17,342 --> 00:56:18,510 PROGRAM. 1611 00:56:18,510 --> 00:56:19,578 SO THE FOUR OF THEM ARE IN FRONT 1612 00:56:19,578 --> 00:56:21,246 OF YOU ON THE SCREEN. 1613 00:56:21,246 --> 00:56:22,848 THE PIONEER, THE NEW INNOVATOR, 1614 00:56:22,848 --> 00:56:25,384 WHICH IS AN ESI EFFORT, EARLY 1615 00:56:25,384 --> 00:56:28,553 STAGE INVESTIGATOR, THE 1616 00:56:28,553 --> 00:56:29,921 TRANSFORMATIVE RESEARCH AWARD 1617 00:56:29,921 --> 00:56:34,192 THAT USES AN R01, AND THE EARLY 1618 00:56:34,192 --> 00:56:35,961 INDEPENDENCE AWARD, WHICH IS 1619 00:56:35,961 --> 00:56:38,096 ALSO KNOWN AS SKIP THE POSTDOC. 1620 00:56:38,096 --> 00:56:39,865 SO WE'RE HERE TO GET CLEARANCE 1621 00:56:39,865 --> 00:56:42,701 FROM YOU ALL ON THE REISSUANCE 1622 00:56:42,701 --> 00:56:44,670 OF THESE FUNDING OPPORTUNITIES. 1623 00:56:44,670 --> 00:56:46,538 SO THE OBJECTIVE OF ALL FOUR OF 1624 00:56:46,538 --> 00:56:50,242 THESE PROGRAMS IS REALLY TO 1625 00:56:50,242 --> 00:56:54,179 ENABLE IMPORTANT INNOVATIVE BOLD 1626 00:56:54,179 --> 00:56:55,380 RESEARCH IDEAS, THREE OF THEM 1627 00:56:55,380 --> 00:56:58,450 ARE VERY HIGHLY FOCUSED ON THE 1628 00:56:58,450 --> 00:56:59,785 INDIVIDUAL, AND THEN THE THIRD 1629 00:56:59,785 --> 00:57:01,553 ONE, THE TRANSFORMATIVE RESEARCH 1630 00:57:01,553 --> 00:57:04,790 PROGRAM, IS MORE PROJECT OR 1631 00:57:04,790 --> 00:57:06,625 PROGRAM, EXPERIMENTALLY FOCUSED. 1632 00:57:06,625 --> 00:57:08,694 BUT REALLY WHAT WE WANT TO DO IS 1633 00:57:08,694 --> 00:57:11,663 TRY TO MOVE FORWARD THAT 1634 00:57:11,663 --> 00:57:12,197 SCIENTIFIC NEEDLE. 1635 00:57:12,197 --> 00:57:13,732 THESE HAVE TO BE BOLD, THESE 1636 00:57:13,732 --> 00:57:17,202 HAVE TO BE INNOVATIVE, THEY HAVE 1637 00:57:17,202 --> 00:57:19,504 TO TEST OR PRESENT OR HOPEFULLY 1638 00:57:19,504 --> 00:57:21,039 MAKE NEW SCIENTIFIC PARADIGMS. 1639 00:57:21,039 --> 00:57:22,774 SO FOR THE FUNDS AVAILABLE, WE 1640 00:57:22,774 --> 00:57:25,644 HAVE LISTED THERE ALMOST 1641 00:57:25,644 --> 00:57:29,114 $60 MILLION PER YEAR OVER THE 1642 00:57:29,114 --> 00:57:30,115 NEXT FIVE YEARS. 1643 00:57:30,115 --> 00:57:32,584 THE ANTICIPATION IS BETWEEN 50 1644 00:57:32,584 --> 00:57:34,986 TO 60 AWARDS PER YEAR. 1645 00:57:34,986 --> 00:57:37,422 AND WE BROKE THAT DOWN FOR 1646 00:57:37,422 --> 00:57:40,225 EXAMPLE FOR NEXT YEAR FOR FISCAL 1647 00:57:40,225 --> 00:57:44,029 YEAR '26, WE WOULD GUESSTIMATE 1648 00:57:44,029 --> 00:57:46,898 EIGHT PIONEER AWARDS, 1649 00:57:46,898 --> 00:57:50,702 APPROXIMATELY 26 NEW INNOVATOR 1650 00:57:50,702 --> 00:57:51,470 AWARDS, SEVEN TRANSFORMATIVE 1651 00:57:51,470 --> 00:57:54,306 RESEARCH AWARDS, AND 13 EARLY 1652 00:57:54,306 --> 00:57:55,507 INDEPENDENCE AWARDS. 1653 00:57:55,507 --> 00:57:59,111 EACH AWARD IS FIVE YEARS. 1654 00:57:59,111 --> 00:58:01,046 BUT THE PROGRAM IS NOT BEING 1655 00:58:01,046 --> 00:58:01,613 RENEWED. 1656 00:58:01,613 --> 00:58:02,614 IT'S JUST THESE FUNDING 1657 00:58:02,614 --> 00:58:06,318 OPPORTUNITIES. 1658 00:58:06,318 --> 00:58:09,254 SO OUR HOPE TODAY IS TO VOTE, 1659 00:58:09,254 --> 00:58:11,123 ALTHOUGH I SAW HOW CHALLENGING 1660 00:58:11,123 --> 00:58:12,891 VOTING IS, VOTE FOR APPROVAL OF 1661 00:58:12,891 --> 00:58:15,927 THE CONCEPT FOR THE FOUR NOTICES 1662 00:58:15,927 --> 00:58:17,896 OF FUNDING OPPORTUNITIES LISTED 1663 00:58:17,896 --> 00:58:18,330 ABOVE. 1664 00:58:18,330 --> 00:58:21,600 SO ON THE NEXT SLIDE, THIS IS 1665 00:58:21,600 --> 00:58:23,335 THE GRAPHIC WE USE FOR OUR FOUR 1666 00:58:23,335 --> 00:58:24,770 INITIATIVES. 1667 00:58:24,770 --> 00:58:26,972 PIONEER, NEW INNOVATOR, 1668 00:58:26,972 --> 00:58:28,273 TRANSFORMATIVE RESEARCH, AND 1669 00:58:28,273 --> 00:58:29,341 EARLY INDEPENDENCE AWARDS. 1670 00:58:29,341 --> 00:58:30,976 ALL OF THEM ARE DESIGNED TO 1671 00:58:30,976 --> 00:58:34,613 FOSTER THESE INCREDIBLE 1672 00:58:34,613 --> 00:58:36,114 SCIENTIFIC LEAPS. 1673 00:58:36,114 --> 00:58:37,549 WE WILL TAKE ANY SCIENTIFIC 1674 00:58:37,549 --> 00:58:39,618 FOCUS, SO ANYTHING WITHIN THE 1675 00:58:39,618 --> 00:58:41,486 MISSION OF NIH IS WELCOME. 1676 00:58:41,486 --> 00:58:45,724 THIS IS THE COMMON FUND'S 1677 00:58:45,724 --> 00:58:49,528 INVESTIGATOR INITIATED ARM. 1678 00:58:49,528 --> 00:58:51,062 FOR ALL FOUR OF THEM, WE DON'T 1679 00:58:51,062 --> 00:58:52,931 NEED ANY PRELIMINARY DATA, WE 1680 00:58:52,931 --> 00:58:54,766 DON'T REQUIRE ANY DETAILED 1681 00:58:54,766 --> 00:58:59,604 EXPERIMENTAL PLAN. 1682 00:58:59,604 --> 00:59:01,439 ALL OF THEM USE RATHER 1683 00:59:01,439 --> 00:59:02,207 NON-STANDARD APPLICATION FORMATS 1684 00:59:02,207 --> 00:59:03,842 AND, IMPORTANTLY, REVIEW 1685 00:59:03,842 --> 00:59:04,176 PROCESSES. 1686 00:59:04,176 --> 00:59:05,811 FOR EXAMPLE, THE PIONEER INN 1687 00:59:05,811 --> 00:59:13,018 VOPIONEE INVOLVE 1688 00:59:13,018 --> 00:59:14,419 AND INTERVIEW WITH THE 1689 00:59:14,419 --> 00:59:16,188 APPLICANTS AND AN ESSAY RATHER 1690 00:59:16,188 --> 00:59:18,890 THAN A REVE RESEARCH STRATEGY. 1691 00:59:18,890 --> 00:59:20,325 WE REALLY WANT THEM TO TELL A 1692 00:59:20,325 --> 00:59:21,593 STORY OF HOW THEIR PROJECT GG TO 1693 00:59:21,593 --> 00:59:22,727 MOVE THE SCIENTIFIC NEEDLE. 1694 00:59:22,727 --> 00:59:27,632 I MENTIONED BEFORE THE HRHR -- 1695 00:59:27,632 --> 00:59:35,507 [INTERRUPTION] 1696 00:59:35,507 --> 00:59:37,142 THAT WAS WEIRD, I GOT A WEIRD 1697 00:59:37,142 --> 00:59:37,576 ECHO. 1698 00:59:37,576 --> 00:59:39,878 THE HRHR PROGRAM IS NOT SUBJECT 1699 00:59:39,878 --> 00:59:42,280 TO THE TENURE TIME LIMIT, BUT 1700 00:59:42,280 --> 00:59:44,349 EACH INDIVIDUAL AWARD IS SUBJECT 1701 00:59:44,349 --> 00:59:47,853 TO A FIVE-YEAR LIMIT FOR THE 1702 00:59:47,853 --> 00:59:55,994 AWARD. 1703 00:59:55,994 --> 00:59:59,564 ALL FOUR OF THE DWOAL GOALS, ALR 1704 00:59:59,564 --> 01:00:01,600 OF THE PROJECTS IS TO FOSTER 1705 01:00:01,600 --> 01:00:03,101 THESE BOLD SCIENTIFIC LEAPS 1706 01:00:03,101 --> 01:00:05,403 FORWARD, AND THE IDEA IS 1707 01:00:05,403 --> 01:00:08,340 SUPPORTING EXCEPTIONAL 1708 01:00:08,340 --> 01:00:11,309 CREATIVITY IN THE SCIENCE. 1709 01:00:11,309 --> 01:00:12,777 WE WANT REALLY INNOVATIVE 1710 01:00:12,777 --> 01:00:13,044 RESEARCH. 1711 01:00:13,044 --> 01:00:14,779 SO WE WANT THE PIE IN THE SKY 1712 01:00:14,779 --> 01:00:15,113 THINGS. 1713 01:00:15,113 --> 01:00:16,848 WHAT WE LOVE TO HEAR IS WHEN THE 1714 01:00:16,848 --> 01:00:18,183 REVIEWERS SAY, I WISH I'D 1715 01:00:18,183 --> 01:00:19,150 THOUGHT OF THAT. 1716 01:00:19,150 --> 01:00:23,288 OR, THIS SOUNDS LIKE SCIENTIFIC 1717 01:00:23,288 --> 01:00:24,189 FICTION, IF THIS COULD HAPPEN, 1718 01:00:24,189 --> 01:00:25,457 THIS WOULD BE AMAZING. 1719 01:00:25,457 --> 01:00:27,759 SO ALL OF THEM HAVE TO RESULT IN 1720 01:00:27,759 --> 01:00:29,494 BOLD AND HIGHLY INNOVATIVE 1721 01:00:29,494 --> 01:00:31,930 RESEARCH. 1722 01:00:31,930 --> 01:00:33,999 BOTH THE NEW INNOVATOR AND EARLY 1723 01:00:33,999 --> 01:00:35,634 INDEPENDENCE AWARDS WILL SUPPORT 1724 01:00:35,634 --> 01:00:39,337 EARLY STAGE INVESTIGATORS, THE 1725 01:00:39,337 --> 01:00:41,439 NIH ESI, EARLY INVESTIGATORS, 1726 01:00:41,439 --> 01:00:42,607 WHICH IS AN IMPORTANT PART OF 1727 01:00:42,607 --> 01:00:44,776 THE PROGRAM AND AN IMPORTANT 1728 01:00:44,776 --> 01:00:50,248 EMPHASIS FOR NIH. 1729 01:00:50,248 --> 01:00:52,317 ON THE NEXT SLIDE, I'LL GO 1730 01:00:52,317 --> 01:00:53,518 QUICKLY THROUGH THE FOUR 1731 01:00:53,518 --> 01:00:53,919 INITIATIVES HERE. 1732 01:00:53,919 --> 01:00:57,555 THE PIE NER. 1733 01:00:57,555 --> 01:00:58,023 PIONEER. 1734 01:00:58,023 --> 01:00:59,324 USUALLY WE SEE MORE SENIOR 1735 01:00:59,324 --> 01:01:00,525 INVESTIGATORS THAT COMPETE 1736 01:01:00,525 --> 01:01:01,393 BETTER FOR THIS. 1737 01:01:01,393 --> 01:01:03,228 IMPORTANTLY, THE RESEARCH 1738 01:01:03,228 --> 01:01:07,832 DIRECTION MUST BE NEW, HENCE THE 1739 01:01:07,832 --> 01:01:09,134 PIONEER NAME, RIGHT, HAS TO TAKE 1740 01:01:09,134 --> 01:01:12,537 UP A MAJOR PORTION OF THEIR 1741 01:01:12,537 --> 01:01:13,838 RESEARCH EFFORTS, MORE THAN 1742 01:01:13,838 --> 01:01:15,273 HALF, FOR THE FIRST THREE YEARS, 1743 01:01:15,273 --> 01:01:17,008 THEN IT TAPERS DOWN BECAUSE 1744 01:01:17,008 --> 01:01:19,177 THESE ARE NOT RENEWABLE. 1745 01:01:19,177 --> 01:01:22,480 THEY'RE HIGHLY FLEXIBLE. 1746 01:01:22,480 --> 01:01:23,648 SO IF SOMETHING NEEDS TO CHANGE 1747 01:01:23,648 --> 01:01:24,883 WITHIN THE FIVE YEARS, IF 1748 01:01:24,883 --> 01:01:27,519 SOMETHING DOESN'T WORK, THE 1749 01:01:27,519 --> 01:01:28,386 INVESTIGATOR IS TOLD TO WORK 1750 01:01:28,386 --> 01:01:29,487 WITH THEIR PROGRAM OFFICER AND 1751 01:01:29,487 --> 01:01:33,091 MAKE CHANGES. 1752 01:01:33,091 --> 01:01:34,826 SO AGAIN WE MAKE APPROXIMATELY 1753 01:01:34,826 --> 01:01:39,197 SEVEN OF THOSE A YEAR. 1754 01:01:39,197 --> 01:01:41,166 THE NEW INNOVATOR AWARD, THIS IS 1755 01:01:41,166 --> 01:01:43,034 THE FIRST ONE THAT SUPPORTS 1756 01:01:43,034 --> 01:01:46,104 EARLY STAGE INVESTIGATORS, AND 1757 01:01:46,104 --> 01:01:47,305 AGAIN, MUST BE HIGHLY 1758 01:01:47,305 --> 01:01:47,706 INNOVATIVE. 1759 01:01:47,706 --> 01:01:49,040 IT'S IN THE TITLE, THAT'S WHAT I 1760 01:01:49,040 --> 01:01:50,241 TELL APPLICANTS ALL THE TIME. 1761 01:01:50,241 --> 01:01:54,145 WE WANT THE INNOVATION TO BE OFF 1762 01:01:54,145 --> 01:01:55,046 THE SCALE. 1763 01:01:55,046 --> 01:01:58,650 AT THE SAME TIME REVIEWERS DO 1764 01:01:58,650 --> 01:02:00,285 FOCUS AT LEAST A LITTLE BIT ON 1765 01:02:00,285 --> 01:02:02,921 FEASIBILITY, SO THEY'RE NOT 1766 01:02:02,921 --> 01:02:03,888 CRAZY INNOVATION, THEY'RE 1767 01:02:03,888 --> 01:02:04,222 DOABLE. 1768 01:02:04,222 --> 01:02:07,726 SO IT'S SIMILAR TO THE PIONEER 1769 01:02:07,726 --> 01:02:09,661 IN SPIRIT BUT AGAIN IT'S ONLY 1770 01:02:09,661 --> 01:02:11,329 EARLY STAGE INVESTIGATORS. 1771 01:02:11,329 --> 01:02:12,297 FOR THOSE OF WHO YOU DON'T 1772 01:02:12,297 --> 01:02:13,164 REMEMBER, THAT'S AN INDIVIDUAL 1773 01:02:13,164 --> 01:02:15,467 THAT'S WITHIN 10 YEARS OF THEIR 1774 01:02:15,467 --> 01:02:19,104 TERMINAL DOCTORATE, THEIR PH.D. 1775 01:02:19,104 --> 01:02:21,573 OR THEIR CLINICAL RESIDENCY IF 1776 01:02:21,573 --> 01:02:23,708 THEY'RE AN M.D. AND THEY MUST 1777 01:02:23,708 --> 01:02:25,477 NOT HAVE RECEIVED A LARGE 1778 01:02:25,477 --> 01:02:28,446 INDEPENDENT NIH GRANT YET. 1779 01:02:28,446 --> 01:02:30,982 SO THEY NEED TO FOCUS 25% OF 1780 01:02:30,982 --> 01:02:33,485 THEIR RESEARCH EFFORT, AND 1781 01:02:33,485 --> 01:02:36,221 AGAIN, THEY HAVE THE REVIEW AND 1782 01:02:36,221 --> 01:02:39,724 THE ESSAY HAS TO FOCUS ON THE 1783 01:02:39,724 --> 01:02:42,560 IDEA, INNOVATION, POTENTIAL 1784 01:02:42,560 --> 01:02:44,496 IMPACT, THE HISTORY, THE TRACK 1785 01:02:44,496 --> 01:02:46,164 RECORD OF INNOVATION FOR THE PI, 1786 01:02:46,164 --> 01:02:47,432 AND THEN, OF COURSE, WHY THIS 1787 01:02:47,432 --> 01:02:49,968 SHOULD BE A NEW INNOVATOR AWARD 1788 01:02:49,968 --> 01:02:51,503 AND NOT AN R01. 1789 01:02:51,503 --> 01:02:56,574 THE NEXT AWARD, ON THE NEXT 1790 01:02:56,574 --> 01:02:58,109 SLIDE, THE TRANS FORMATIVE 1791 01:02:58,109 --> 01:02:59,411 RESEARCH AWARD, WE ACTUALLY DO 1792 01:02:59,411 --> 01:03:01,679 USE AN R01 MECHANISM, A MORE 1793 01:03:01,679 --> 01:03:02,814 TRADITIONAL MECHANISM, BUT WE 1794 01:03:02,814 --> 01:03:06,951 USE IT VERY DIFFERENTLY. 1795 01:03:06,951 --> 01:03:08,553 THIS AWARD, DIFFERENT FROM ALL 1796 01:03:08,553 --> 01:03:09,120 THE OTHERS, COULD SUPPORT A 1797 01:03:09,120 --> 01:03:11,322 PROJECT THAT MIGHT BE A TEAM 1798 01:03:11,322 --> 01:03:12,524 APPROACH IT COULD ALSO BE A 1799 01:03:12,524 --> 01:03:13,658 SINGLE PI BUT YOU COULD HAVE A 1800 01:03:13,658 --> 01:03:14,392 TEAM HERE. 1801 01:03:14,392 --> 01:03:15,827 THE BUDGET IS FLEXIBLE. 1802 01:03:15,827 --> 01:03:17,028 IT'S NOT FIXED. 1803 01:03:17,028 --> 01:03:19,330 IT HAS TO BE VERY WELL JUSTIFIED 1804 01:03:19,330 --> 01:03:20,732 BUT IT'S NOT FIXED AT A CERTAIN 1805 01:03:20,732 --> 01:03:22,801 AMOUNT. 1806 01:03:22,801 --> 01:03:24,669 THERE'S A LITTLE BIT MORE 1807 01:03:24,669 --> 01:03:28,073 EMPHASIS HERE ON THE PROJECT 1808 01:03:28,073 --> 01:03:29,407 VERSUS ON JUST THE PI. 1809 01:03:29,407 --> 01:03:31,810 THE PI OF COURSE HAS TO BE 1810 01:03:31,810 --> 01:03:33,611 STELLAR BUT REALLY THE REVIEWERS 1811 01:03:33,611 --> 01:03:37,382 ARE TOLD TO LOOK AT THE PROJECT. 1812 01:03:37,382 --> 01:03:38,616 AGAIN, YOU DO NOT NEED 1813 01:03:38,616 --> 01:03:42,220 PRELIMINARY DATA, YOU DON'T NEED 1814 01:03:42,220 --> 01:03:44,422 A DETAILED EXPERIMENTAL PLAN. 1815 01:03:44,422 --> 01:03:50,862 SO THE LAST ONE, THE FOURTH ONE, 1816 01:03:50,862 --> 01:03:52,497 IS THE NIH DIRECTOR'S EARLY 1817 01:03:52,497 --> 01:03:53,465 INDEPENDENCE AWARD, RIGHT? 1818 01:03:53,465 --> 01:03:58,937 SO THESE ARE INDIVIDUALS 1819 01:03:58,937 --> 01:04:00,038 SKIPPING THEIR INDIVIDUAL 1820 01:04:00,038 --> 01:04:01,372 POSTDOC AND IT'S FOR A REALLY 1821 01:04:01,372 --> 01:04:02,440 SPECIAL GROUP OF STUDENTS THAT 1822 01:04:02,440 --> 01:04:03,541 ARE GRADUATING AND THE TIME 1823 01:04:03,541 --> 01:04:04,742 WINDOW IS PRETTY TIGHT, I WON'T 1824 01:04:04,742 --> 01:04:07,145 GO INTO IT HERE. 1825 01:04:07,145 --> 01:04:10,081 BUT ABOUT A YEAR WITHIN THE TIME 1826 01:04:10,081 --> 01:04:16,754 OF THE APPLICATION, THEY HAVE TO 1827 01:04:16,754 --> 01:04:18,056 REALLY DEMONSTRATE AN INCREDIBLE 1828 01:04:18,056 --> 01:04:18,823 TRACK RECORD OF WHAT THEY'VE 1829 01:04:18,823 --> 01:04:19,824 DONE IN THE PAST. 1830 01:04:19,824 --> 01:04:20,859 THE OTHER THING THAT'S IMPORTANT 1831 01:04:20,859 --> 01:04:23,428 IS THE INSTITUTION SUPPORTING 1832 01:04:23,428 --> 01:04:25,163 THE APPLICATION, WHO'S THE REAL 1833 01:04:25,163 --> 01:04:28,766 APPLICANT, RIGHT, MUST GIVE 1834 01:04:28,766 --> 01:04:31,636 DEMONSTRATION OF REALLY 1835 01:04:31,636 --> 01:04:32,837 SUBSTANTIAL SUPPORT, COMMITMENT, 1836 01:04:32,837 --> 01:04:34,172 MONETARY COMMITMENT, SPACE, ET 1837 01:04:34,172 --> 01:04:38,009 CETERA, TO THAT INDIVIDUAL. 1838 01:04:38,009 --> 01:04:40,378 IF THEY RECEIVE AN AWARD, THE PI 1839 01:04:40,378 --> 01:04:42,580 WILL COMMIT 80% EFFORT AND THEY 1840 01:04:42,580 --> 01:04:44,315 MUST HAVE THAT AVAILABLE 1841 01:04:44,315 --> 01:04:45,016 RESEARCH EFFORT TIME THAT THEY 1842 01:04:45,016 --> 01:04:51,422 CAN GIVE. 1843 01:04:51,422 --> 01:04:52,991 SO JUST A LITTLE TASTE, I REALLY 1844 01:04:52,991 --> 01:04:54,826 CAN'T GIVE YOU ALL THE IMPACT 1845 01:04:54,826 --> 01:04:57,662 THAT THESE AWARDS HAVE MADE OVER 1846 01:04:57,662 --> 01:05:01,833 THE MANY YEARS. 1847 01:05:01,833 --> 01:05:03,935 YOU CAN GO TO OUR WEBSITE THIS, 1848 01:05:03,935 --> 01:05:05,570 IS JUST A SNAPSHOT OF SOME OF 1849 01:05:05,570 --> 01:05:06,838 THE RECENT HIGHLIGHTS WE'VE PUT 1850 01:05:06,838 --> 01:05:08,173 OUT THERE THAT HAVE BEEN REALLY 1851 01:05:08,173 --> 01:05:10,775 IMPORTANT SO WE HAVE AREAS OF 1852 01:05:10,775 --> 01:05:15,180 RESEARCH IN ALZHEIMER'S DISEASE, 1853 01:05:15,180 --> 01:05:19,317 KIDNEY DISEASE, MICROBIOME, GUT 1854 01:05:19,317 --> 01:05:20,485 INFLAMMATION, AND THEN THE LAST 1855 01:05:20,485 --> 01:05:25,690 ONE THERE IS DEVELOPMENT OF 1856 01:05:25,690 --> 01:05:26,558 LANGUAGE. 1857 01:05:26,558 --> 01:05:28,960 WE CHOSE THESE BECAUSE THEY'RE 1858 01:05:28,960 --> 01:05:29,928 RECENT, BUT ALSO TO GIVE YOU AN 1859 01:05:29,928 --> 01:05:31,362 IDEA OF HOW BROAD THE SCIENTIFIC 1860 01:05:31,362 --> 01:05:33,565 AREAS ARE WITH THE HRHR PROGRAM. 1861 01:05:33,565 --> 01:05:37,268 WE REALLY AIM TO HIT THE WHOLE 1862 01:05:37,268 --> 01:05:38,603 SCIENTIFIC ENTERPRISE OF NIH, 1863 01:05:38,603 --> 01:05:40,872 AND THAT'S HIGHLIGHTED ON THE 1864 01:05:40,872 --> 01:05:42,307 NEXT SLIDE WHICH IS THE WORKING 1865 01:05:42,307 --> 01:05:44,943 GROUP THAT I WORK WITH, WORK 1866 01:05:44,943 --> 01:05:51,382 VERY CLOSELY WITH, SOME HAVE 1867 01:05:51,382 --> 01:05:52,150 CHANGED VERY RECENTLY BUT YOU 1868 01:05:52,150 --> 01:05:54,552 CAN SEE IF YOU WANTED TO THAT 1869 01:05:54,552 --> 01:05:55,653 ALL 27 INSTITUTES AND CENTERS 1870 01:05:55,653 --> 01:05:58,489 ARE REPRESENTED HERE AND THESE 1871 01:05:58,489 --> 01:05:59,457 INDIVIDUALS PITCH IN, THEY 1872 01:05:59,457 --> 01:06:01,459 REALLY ARE A WONDERFUL GROUP, 1873 01:06:01,459 --> 01:06:05,330 BUT THIS IS PART OF WHY WE CAN 1874 01:06:05,330 --> 01:06:06,898 LOOK AT THE ENTIRE RESEARCH 1875 01:06:06,898 --> 01:06:09,968 ENTERPRISE. 1876 01:06:09,968 --> 01:06:11,502 SO ON THE NEXT SLIDE, I BELIEVE 1877 01:06:11,502 --> 01:06:14,772 IT'S -- YEAH, I TOSS THIS BACK 1878 01:06:14,772 --> 01:06:18,042 TO YOU, FRANZISKA, OR QUESTIONS? 1879 01:06:18,042 --> 01:06:20,812 I DON'T REMEMBER. 1880 01:06:20,812 --> 01:06:22,213 >> THANK YOU VERY MUCH. 1881 01:06:22,213 --> 01:06:25,450 SO ACTUALLY WE'LL NOW GO TO OUR 1882 01:06:25,450 --> 01:06:28,253 ASSIGNED DISCUSSANTS. 1883 01:06:28,253 --> 01:06:29,354 HOPEFULLY WE HAVE THE AUDIO 1884 01:06:29,354 --> 01:06:32,957 ISSUES WORKED OUT FOR DR. MANLY. 1885 01:06:32,957 --> 01:06:33,524 DR. MANLY, DO YOU -- 1886 01:06:33,524 --> 01:06:34,359 >> I HOPE SO TOO. 1887 01:06:34,359 --> 01:06:36,461 >> YES, GREAT, WE CAN HEAR YOU. 1888 01:06:36,461 --> 01:06:37,161 >> WOO! 1889 01:06:37,161 --> 01:06:38,162 YOU CAN HEAR ME. 1890 01:06:38,162 --> 01:06:40,331 I'LL INTRODUCE MYSELF THEN 1891 01:06:40,331 --> 01:06:40,898 QUICKLY. 1892 01:06:40,898 --> 01:06:44,702 I'M A PROFESSOR IN THE NEUROLOGY 1893 01:06:44,702 --> 01:06:48,206 DEPARTMENT AT COLUMBIA 1894 01:06:48,206 --> 01:06:51,676 UNIVERSITY, AND I WAS PREVIOUSLY 1895 01:06:51,676 --> 01:06:55,647 ON THE NIA, THE COUNCIL ON 1896 01:06:55,647 --> 01:06:59,150 AGING, AND I'M VERY HAPPY TO BE 1897 01:06:59,150 --> 01:07:01,419 DISCUSSING THE HIGH RISK, HIGH 1898 01:07:01,419 --> 01:07:04,822 REWARD PROGRAM TODAY, THE 1899 01:07:04,822 --> 01:07:08,426 ADVANTAGES AND SUCCESSES ARE 1900 01:07:08,426 --> 01:07:09,193 MANY. 1901 01:07:09,193 --> 01:07:12,730 THE EXISTENCE OF A PROGRAM THAT 1902 01:07:12,730 --> 01:07:14,732 FOCUSES ON ENCOURAGE SOMETHING 1903 01:07:14,732 --> 01:07:22,307 CREATIVITY AND INNOVATION IN NIH 1904 01:07:22,307 --> 01:07:25,376 RESEARCH -- 1905 01:07:25,376 --> 01:07:27,879 >> DR. MANLY, UNFORTUNATELY WE 1906 01:07:27,879 --> 01:07:34,252 HAVE LOST YOUR AUDIO. 1907 01:07:34,252 --> 01:07:35,787 JUST GIVE IT A MOMENT TO SEE IF 1908 01:07:35,787 --> 01:07:38,456 WE CAN REGAIN -- 1909 01:07:38,456 --> 01:07:40,024 >> CAN YOU HEAR ME? 1910 01:07:40,024 --> 01:07:41,492 >> WE CAN HEAR YOU NOW. 1911 01:07:41,492 --> 01:07:42,493 IT SEEMS TO BE CUTTING IN AND 1912 01:07:42,493 --> 01:07:43,661 OUT. 1913 01:07:43,661 --> 01:07:45,096 I WOULD SUGGEST IF THAT HAPPENS 1914 01:07:45,096 --> 01:07:46,197 AGAIN, MAYBE TRY TURNING OFF 1915 01:07:46,197 --> 01:07:47,932 YOUR CAMERA TO SAVE BANDWIDTH, 1916 01:07:47,932 --> 01:07:49,634 BUT PLEASE GO AHEAD. 1917 01:07:49,634 --> 01:07:53,104 >> OKAY. 1918 01:07:53,104 --> 01:07:57,375 AS I WAS SAYING, THE SUPPORT FOR 1919 01:07:57,375 --> 01:08:00,812 EARLY STAGE INVESTIGATORS FOR 1920 01:08:00,812 --> 01:08:04,248 TWO OUT OF FOUR OF THESE AWARDS 1921 01:08:04,248 --> 01:08:08,653 AND THE BROAD IMPACT ACROSS THE 1922 01:08:08,653 --> 01:08:12,156 NIH ARE ALL ADVANTAGES. 1923 01:08:12,156 --> 01:08:19,030 I HAD SOME QUESTIONS, THOUGH. 1924 01:08:19,030 --> 01:08:19,731 SPECIFICALLY THE QUESTIONS ARE 1925 01:08:19,731 --> 01:08:24,202 WHAT ARE THE SPECIFIC METRICS OF 1926 01:08:24,202 --> 01:08:27,505 SUCCESS FOR THE HIGH RISK/HIGH 1927 01:08:27,505 --> 01:08:27,905 REWARD PROGRAM? 1928 01:08:27,905 --> 01:08:29,774 IN THE MATERIALS GIVEN, WE WERE 1929 01:08:29,774 --> 01:08:31,209 GIVEN A SNAPSHOT, YOU JUST 1930 01:08:31,209 --> 01:08:35,913 TALKED ABOUT IT, I FOLLOWED THE 1931 01:08:35,913 --> 01:08:36,214 LINK. 1932 01:08:36,214 --> 01:08:39,951 A LOT OF DIFFERENT GRANTS ARE 1933 01:08:39,951 --> 01:08:42,353 REPRESENTED AFTER YOU FOLLOW 1934 01:08:42,353 --> 01:08:47,492 THAT LINK, SO IT WAS HARD TO 1935 01:08:47,492 --> 01:08:51,329 IDENTIFY EXACTLY WHICH OF THOSE 1936 01:08:51,329 --> 01:08:59,203 NEWS STORIES -- 1937 01:08:59,203 --> 01:09:01,406 >> SORRY, DR. MANLY, WE HAVE 1938 01:09:01,406 --> 01:09:03,908 LOST YOU AGAIN. 1939 01:09:03,908 --> 01:09:06,544 I WOULD SUGGEST AT THIS STAGE 1940 01:09:06,544 --> 01:09:10,047 TRYING TO TURN OFF VIDEO TO SAVE 1941 01:09:10,047 --> 01:09:11,149 BANDWIDTH AND THEN HOPEFULLY WE 1942 01:09:11,149 --> 01:09:14,051 CAN GET YOUR AUDIO BACK? 1943 01:09:14,051 --> 01:09:14,285 >> YEP. 1944 01:09:14,285 --> 01:09:15,920 >> WE CAN HEAR YOU NOW. 1945 01:09:15,920 --> 01:09:19,424 YES. 1946 01:09:19,424 --> 01:09:23,594 >> SO WHAT ARE SOME OF THE -- 1947 01:09:23,594 --> 01:09:26,097 WHAT'S SOME OF THE EVIDENCE THAT 1948 01:09:26,097 --> 01:09:31,569 THE FOLKS WHO ARE AWARDED, HIGH 1949 01:09:31,569 --> 01:09:33,337 RISK/HIGH REWARD AWARDS, ARE 1950 01:09:33,337 --> 01:09:34,839 INDEED BOLD AND HIGHLY 1951 01:09:34,839 --> 01:09:36,607 INNOVATIVE RESEARCH. 1952 01:09:36,607 --> 01:09:38,476 WOULD SOME OF THE EVIDENCE BE 1953 01:09:38,476 --> 01:09:44,282 HIGH IMPACT PUBLICATIONS, NOVEL 1954 01:09:44,282 --> 01:09:45,683 DISCOVERIES, LIFE-CHANGING 1955 01:09:45,683 --> 01:09:46,117 TREATMENTS. 1956 01:09:46,117 --> 01:09:47,652 WHAT IS SOME OF THE EVIDENCE 1957 01:09:47,652 --> 01:09:50,721 THAT THESE HIGH RISK/HIGH REWARD 1958 01:09:50,721 --> 01:09:53,024 PROGRAMS ENGAGE SCIENTISTS 1959 01:09:53,024 --> 01:09:55,293 ACROSS ALL OF THE NIH INSTITUTES 1960 01:09:55,293 --> 01:09:59,030 AND ALL OF THE DISCIPLINES THAT 1961 01:09:59,030 --> 01:10:04,569 ARE REPRESENTED IN NIH? 1962 01:10:04,569 --> 01:10:07,505 ALL OF THE SIGNS WE HAVE NOW 1963 01:10:07,505 --> 01:10:08,706 POINT TO THE FUTURE BUDGET OF 1964 01:10:08,706 --> 01:10:12,310 NIH TO BE DRASTICALLY REDUCED. 1965 01:10:12,310 --> 01:10:16,914 HOW DO WE VIEW THE ROLE OF HIGH 1966 01:10:16,914 --> 01:10:20,084 RISK/HIGH REWARD PROGRAMS IN THE 1967 01:10:20,084 --> 01:10:22,720 CONTEXT OF DRASTICALLY REDUCED 1968 01:10:22,720 --> 01:10:23,054 RESOURCES. 1969 01:10:23,054 --> 01:10:26,424 FOR EXAMPLE, SHOULD THE HIGH 1970 01:10:26,424 --> 01:10:28,493 RISK/HIGH REWARD PROGRAM BE EVEN 1971 01:10:28,493 --> 01:10:31,462 MORE FOCUSED ON EARLY CAREER 1972 01:10:31,462 --> 01:10:32,396 RESEARCHERS GIVEN THE FUNDING 1973 01:10:32,396 --> 01:10:33,631 ENVIRONMENT THAT WE'RE ABOUT TO 1974 01:10:33,631 --> 01:10:35,566 ENTER. 1975 01:10:35,566 --> 01:10:39,604 AND THEN I ASK WHAT ARE THE 1976 01:10:39,604 --> 01:10:42,773 SPECIFIC OUTCOMES OF THE EARLY 1977 01:10:42,773 --> 01:10:43,207 INDEPENDENCE AWARD? 1978 01:10:43,207 --> 01:10:45,510 THIS IS THE ONE THAT ALLOWS FOR 1979 01:10:45,510 --> 01:10:46,844 POSTDOC TO BE SKIPPED. 1980 01:10:46,844 --> 01:10:49,680 WE WANT THESE SCIENTISTS TO BE 1981 01:10:49,680 --> 01:10:50,448 SUCCESSFUL, BUT WHAT IS THE 1982 01:10:50,448 --> 01:10:51,849 EVIDENCE THAT THEY ARE 1983 01:10:51,849 --> 01:10:55,486 SUCCESSFUL IN OBTAINING 1984 01:10:55,486 --> 01:10:58,322 R01 AWARDS AND PROMOTION TO 1985 01:10:58,322 --> 01:10:59,724 ASSOCIATE OR PROMOTION TO 1986 01:10:59,724 --> 01:11:03,127 TENURE? 1987 01:11:03,127 --> 01:11:05,863 AND THOSE ARE MY COMMENTS. 1988 01:11:05,863 --> 01:11:09,066 SORRY ABOUT THE AUDIO ISSUES. 1989 01:11:09,066 --> 01:11:11,435 >> OKAY. 1990 01:11:11,435 --> 01:11:12,737 I CAN -- THERE'S A LOT OF 1991 01:11:12,737 --> 01:11:13,938 QUESTIONS THERE BUT I CAN TRY TO 1992 01:11:13,938 --> 01:11:16,707 ANSWER SOME OF THESE. 1993 01:11:16,707 --> 01:11:20,745 THE METRICS OF SUCCESS, SOME OF 1994 01:11:20,745 --> 01:11:22,146 THEM ARE ONES THAT YOU CITED 1995 01:11:22,146 --> 01:11:23,381 THAT YOU MIGHT IMAGINE, THINGS 1996 01:11:23,381 --> 01:11:24,916 LIKE FOLLOW-ON FUNDING 1997 01:11:24,916 --> 01:11:30,321 ESPECIALLY FOR THE ESI PROGRAM, 1998 01:11:30,321 --> 01:11:33,357 THE NEW INNOVATORS AND THE EARLY 1999 01:11:33,357 --> 01:11:34,692 STAGE -- EARLY INDEPENDENCE 2000 01:11:34,692 --> 01:11:35,893 AWARD, FOLLOW-ON FUND SOMETHING 2001 01:11:35,893 --> 01:11:41,566 A HUGE METRIC OF SUCCESS. 2002 01:11:41,566 --> 01:11:42,733 OFTEN TENURE COMES TO THESE 2003 01:11:42,733 --> 01:11:43,668 FOLKS A LITTLE FURTHER OUT, SO 2004 01:11:43,668 --> 01:11:45,202 I'M NOT SURE THAT WE HAVE THOSE 2005 01:11:45,202 --> 01:11:45,536 DATA. 2006 01:11:45,536 --> 01:11:48,272 WE HAVE IT FOR DP2s FOR THE 2007 01:11:48,272 --> 01:11:50,041 NEW INNOVATORS BUT NOT EARLY 2008 01:11:50,041 --> 01:11:52,443 INDEPENDENCE AWARDEES. 2009 01:11:52,443 --> 01:11:53,644 ALTHOUGH IN A MINUTE, BECKY, I'M 2010 01:11:53,644 --> 01:11:54,879 GOING TO HAND IT OVER TO YOU TO 2011 01:11:54,879 --> 01:11:56,514 TALK ABOUT THAT. 2012 01:11:56,514 --> 01:11:57,048 WARNING. 2013 01:11:57,048 --> 01:12:00,284 FOR PIONEERS AND TRANSFORMATIVE 2014 01:12:00,284 --> 01:12:03,220 RESEARCH AWARDS, OBVIOUSLY ONE 2015 01:12:03,220 --> 01:12:04,956 OF THE METRICS OF SUCCESS WOULD 2016 01:12:04,956 --> 01:12:06,924 BE IMPORTANT PAPERS. 2017 01:12:06,924 --> 01:12:08,459 AND IMPACT IN THE FIELD THAT 2018 01:12:08,459 --> 01:12:10,861 THOSE PAPERS ARE USED. 2019 01:12:10,861 --> 01:12:14,599 WE OFTEN USE RELATIVE CITATION 2020 01:12:14,599 --> 01:12:17,234 RATIO TO FIGURE OUT THAT PAPERS 2021 01:12:17,234 --> 01:12:18,569 AREN'T JUST PUBLISHED AND 2022 01:12:18,569 --> 01:12:19,870 IGNORED, THAT THEY'RE ACTUALLY 2023 01:12:19,870 --> 01:12:21,839 CITED AND BUILT ON, SO AGAIN, 2024 01:12:21,839 --> 01:12:22,940 THIS TAKES TIME. 2025 01:12:22,940 --> 01:12:25,910 YOU CAN'T MEASURE THAT TWO OR 2026 01:12:25,910 --> 01:12:27,111 THREE YEARS AFTER THE END OF THE 2027 01:12:27,111 --> 01:12:27,545 AWARD. 2028 01:12:27,545 --> 01:12:29,080 IT TAKES A LITTLE WHILE, BUT 2029 01:12:29,080 --> 01:12:30,514 THAT'S ANOTHER WAY THAT WE LOOK 2030 01:12:30,514 --> 01:12:30,948 AT THESE. 2031 01:12:30,948 --> 01:12:32,383 IN FACT, WE'RE RIGHT IN THE 2032 01:12:32,383 --> 01:12:35,586 MIDDLE NOW OF DOING AN INTERNAL 2033 01:12:35,586 --> 01:12:39,056 EVALUATION FOR THE TOP 10 2034 01:12:39,056 --> 01:12:40,925 FINDINGS FROM THE HRHR PROGRAM. 2035 01:12:40,925 --> 01:12:42,026 THAT'S ONE OF THE THINGS THAT I 2036 01:12:42,026 --> 01:12:44,128 REALLY WANT TO BE ABLE TO 2037 01:12:44,128 --> 01:12:50,234 ARTICULATE VERY CLEARLY. 2038 01:12:50,234 --> 01:12:51,502 THE EVIDENCE FOR IMPACT ACROSS 2039 01:12:51,502 --> 01:13:00,811 ALL THE INSTITUTES AND CENTERS, 2040 01:13:00,811 --> 01:13:02,880 THE WAY MOST OF THESE AWARDS 2041 01:13:02,880 --> 01:13:04,315 WORK, EVERYTHING OTHER THAN THE 2042 01:13:04,315 --> 01:13:06,150 EARLY INDEPENDENCE AWARDS, 2043 01:13:06,150 --> 01:13:07,385 ALTHOUGH IT'S OFFICE OF DIRECTOR 2044 01:13:07,385 --> 01:13:10,354 FUNDS, THEY'RE ADMINISTERED OUT 2045 01:13:10,354 --> 01:13:14,558 THERE IN ONE OF THE OTHER 26 2046 01:13:14,558 --> 01:13:16,060 INSTITUTES OR CENTERS SO THEY'RE 2047 01:13:16,060 --> 01:13:21,632 MOVED OUT TO NCI OR NHLBI OR 2048 01:13:21,632 --> 01:13:25,136 WHEREVER THAT'S REALLY AN 2049 01:13:25,136 --> 01:13:26,037 IMPORTANT ASPECT OF THE PROGRAM 2050 01:13:26,037 --> 01:13:27,338 AND THAT'S HOW WE CAN SORT OF 2051 01:13:27,338 --> 01:13:29,907 MEASURE THAT WE ARE HITTING ALL 2052 01:13:29,907 --> 01:13:31,709 OF THE INSTITUTES AND CENTERS AT 2053 01:13:31,709 --> 01:13:34,145 NIH AND THAT ALL OF THE 2054 01:13:34,145 --> 01:13:35,112 INSTITUTES AND CENTERS AT NIH 2055 01:13:35,112 --> 01:13:37,982 ARE VERY EAGER TO TAKE THESE ON, 2056 01:13:37,982 --> 01:13:40,851 AND WE PLACE THEM WHERE THEY'RE 2057 01:13:40,851 --> 01:13:42,486 MOST SCIENTIFICALLY RELEVANT. 2058 01:13:42,486 --> 01:13:44,255 I DON'T HAVE THE DATA AT MY 2059 01:13:44,255 --> 01:13:45,256 FINGERTIPS BUT WE WOULD HAVE TO 2060 01:13:45,256 --> 01:13:47,224 PULL THAT UP FOR YOU BUT I 2061 01:13:47,224 --> 01:13:48,426 ASSURE YOU THAT SOME OF THE 2062 01:13:48,426 --> 01:13:49,527 SMALLER INSTITUTES AND CENTERS 2063 01:13:49,527 --> 01:13:54,398 ARE WELL REPRESENTED IN OUR 2064 01:13:54,398 --> 01:13:55,466 PORTFOLIO. 2065 01:13:55,466 --> 01:13:57,902 I CAN'T REALLY COMMENT ON THE 2066 01:13:57,902 --> 01:14:00,104 ROLE OF HRHR RESEARCH IN THE NIH 2067 01:14:00,104 --> 01:14:00,404 BUDGET. 2068 01:14:00,404 --> 01:14:01,472 I THINK THAT WILL BE A QUESTION 2069 01:14:01,472 --> 01:14:07,011 YOU CAN ASK SOME OF THE OTHER 2070 01:14:07,011 --> 01:14:09,213 NIH LEADERS COMING ON LATER 2071 01:14:09,213 --> 01:14:10,214 TODAY, I DON'T THINK THAT'S 2072 01:14:10,214 --> 01:14:11,315 SOMETHING I CAN COMMENT ON. 2073 01:14:11,315 --> 01:14:12,516 BECKY, DO YOU WANT TO TALK JUST 2074 01:14:12,516 --> 01:14:17,888 A LITTLE BIT ABOUT THE SUCCESS 2075 01:14:17,888 --> 01:14:21,425 OF THE EARLY INVESTIGATOR AWARD 2076 01:14:21,425 --> 01:14:21,859 RECIPIENTS? 2077 01:14:21,859 --> 01:14:23,594 >> SO FOR ALL FOUR INITIATIVES 2078 01:14:23,594 --> 01:14:27,064 IN OUR PROGRAM, WE'VE HAD A 2079 01:14:27,064 --> 01:14:28,132 THIRD PARTY EVALUATOR LOOK AT 2080 01:14:28,132 --> 01:14:30,101 THEM TO ACTUALLY CHART TO SEE 2081 01:14:30,101 --> 01:14:33,471 HOW WELL WE ARE DOING IN OUR 2082 01:14:33,471 --> 01:14:35,206 GOAL OF SUCCESSFULLY SUPPORTING 2083 01:14:35,206 --> 01:14:37,541 HIGH RISK RESEARCH. 2084 01:14:37,541 --> 01:14:40,511 FOR ALL THOSE, THEY ACTUALLY 2085 01:14:40,511 --> 01:14:43,047 DID -- THEY COMPARED OUR COHORTS 2086 01:14:43,047 --> 01:14:47,318 WITH A MATCHED R01 POOL TO LOOK 2087 01:14:47,318 --> 01:14:48,919 AT OUTPUTS AND VIEW WHETHER OR 2088 01:14:48,919 --> 01:14:53,023 NOT WE ARE, IN FACT, SEEING MORE 2089 01:14:53,023 --> 01:14:54,558 INNOVATIVE SCIENCE OUT OF OUR 2090 01:14:54,558 --> 01:14:54,792 GROUP. 2091 01:14:54,792 --> 01:14:57,962 A LOT OF DETAILS TO THAT BUT IN 2092 01:14:57,962 --> 01:14:59,396 GENERAL, FOR ALL FOUR 2093 01:14:59,396 --> 01:15:01,265 INITIATIVES, THOSE RESULTS -- 2094 01:15:01,265 --> 01:15:04,435 THE EVALUATOR DID FIND WE WERE 2095 01:15:04,435 --> 01:15:07,171 SUCCESSFULLY ABLE TO SUPPORT 2096 01:15:07,171 --> 01:15:09,039 HIGH RISK SCIENCE SO A LOT OF 2097 01:15:09,039 --> 01:15:10,007 THOSE EVALUATIONS THAT ARE ON 2098 01:15:10,007 --> 01:15:11,342 OUR WEBSITE, YOU'RE WELCOME TO 2099 01:15:11,342 --> 01:15:14,211 GO LOOK THROUGH THEM, BUT IN 2100 01:15:14,211 --> 01:15:15,179 GENERAL, THEY HAVE FOUND THAT WE 2101 01:15:15,179 --> 01:15:16,947 ARE ABLE TO SUPPORT AND ARE 2102 01:15:16,947 --> 01:15:20,151 FINDING THOSE HIGH RISK 2103 01:15:20,151 --> 01:15:22,887 PROJECTS. 2104 01:15:22,887 --> 01:15:24,388 FOR THE EARLY INDEPENDENCE AWARD 2105 01:15:24,388 --> 01:15:27,024 WE ALSO HAD A THIRD PARTY 2106 01:15:27,024 --> 01:15:28,692 INVESTIGATE CONDUCTED ON IT. 2107 01:15:28,692 --> 01:15:30,861 AS YOU CAN IMAGINE IT WAS REALLY 2108 01:15:30,861 --> 01:15:32,730 HARD TO FIND A REALLY GOOD 2109 01:15:32,730 --> 01:15:35,900 COMPARISON GROUP FOR THESE BATCH 2110 01:15:35,900 --> 01:15:38,035 OF VERY AMBITIOUS AND MATURE 2111 01:15:38,035 --> 01:15:39,103 SCIENTISTS JUST COMING RIGHT OUT 2112 01:15:39,103 --> 01:15:39,770 OF GRAD SCHOOL. 2113 01:15:39,770 --> 01:15:44,775 SO THEY USED ESI R01 AND THEY 2114 01:15:44,775 --> 01:15:46,911 WERE ABLE TO CONDUCT SURVEYS, 2115 01:15:46,911 --> 01:15:48,712 THEY LOOKED AT THINGS LIKE 2116 01:15:48,712 --> 01:15:49,947 CAREER ADVANCEMENT SO WHEN DID 2117 01:15:49,947 --> 01:15:54,552 YOU GET TENURE, WHAT WERE YOUR 2118 01:15:54,552 --> 01:15:56,854 RESEARCH OUTPUTS, FOLLOW-ON 2119 01:15:56,854 --> 01:15:57,655 FUNDING, ALL OF THAT 2120 01:15:57,655 --> 01:15:58,989 INFORMATION, AND THEY FOUND THE 2121 01:15:58,989 --> 01:16:01,258 EARLY INDEPENDENCE AWARDEES WERE 2122 01:16:01,258 --> 01:16:05,796 ABLE TO -- THEY MATCHED THE ESI 2123 01:16:05,796 --> 01:16:06,764 R01 COMPARISON POOL IN TERMS OF 2124 01:16:06,764 --> 01:16:08,866 LENGTH OF TIME FOR TENURE, THEIR 2125 01:16:08,866 --> 01:16:11,836 RESEARCH OUTPUTS AND ALL OF 2126 01:16:11,836 --> 01:16:14,038 THAT, AND THEY WERE ABLE TO DO 2127 01:16:14,038 --> 01:16:15,139 ALL THIS AFTER SKIPPING 2128 01:16:15,139 --> 01:16:17,408 ADDITIONAL TRAINING, SO WE FELT 2129 01:16:17,408 --> 01:16:19,643 THAT WAS A GREAT SUCCESS FOR THE 2130 01:16:19,643 --> 01:16:22,079 EARLY INDEPENDENCE AWARD. 2131 01:16:22,079 --> 01:16:23,581 >> I WANT TO MENTION, I DIDN'T 2132 01:16:23,581 --> 01:16:25,783 SAY THIS, THAT THE EARLY 2133 01:16:25,783 --> 01:16:27,384 INDEPENDENCE AWARDS ARE MANAGED 2134 01:16:27,384 --> 01:16:28,252 DIRECTLY BY BECKY. 2135 01:16:28,252 --> 01:16:30,187 SHE IS THE PROGRAM OFFICER FOR 2136 01:16:30,187 --> 01:16:31,889 ALL OF THOSE AWARDS. 2137 01:16:31,889 --> 01:16:33,757 SHE GOES ON SITE VISITS, MEETS 2138 01:16:33,757 --> 01:16:36,493 WITH PIs, MEETS WITH THE 2139 01:16:36,493 --> 01:16:39,563 INSTITUTIONS TO MAKE SURE THAT 2140 01:16:39,563 --> 01:16:41,031 THE GOALS OF THE PROGRAM ARE 2141 01:16:41,031 --> 01:16:43,300 SUPPORTED AND THAT THOSE PIs 2142 01:16:43,300 --> 01:16:45,169 HAVE THE SUPPORT THAT WAS 2143 01:16:45,169 --> 01:16:46,737 PROMISED TO THEM IN THE 2144 01:16:46,737 --> 01:16:47,338 APPLICATION BECAUSE THAT'S A 2145 01:16:47,338 --> 01:16:49,373 HUGE PART OF THIS, THE 2146 01:16:49,373 --> 01:16:52,109 INSTITUTIONAL SUPPORT MATTERS A 2147 01:16:52,109 --> 01:16:54,411 LOT. 2148 01:16:54,411 --> 01:16:56,146 >> I AGREE. 2149 01:16:56,146 --> 01:16:59,917 THANK YOU FOR YOUR ANSWERS. 2150 01:16:59,917 --> 01:17:02,953 >> THANK YOU ALL. 2151 01:17:02,953 --> 01:17:06,257 NOW I'LL TURN IT OVER TO 2152 01:17:06,257 --> 01:17:07,491 DR. GANDHI TO ADD ANY COMMENTS. 2153 01:17:07,491 --> 01:17:09,793 >> SO I HIGHLY SUPPORT ALL FOUR 2154 01:17:09,793 --> 01:17:13,864 OF THESE, THE RECENT EVENTS HAVE 2155 01:17:13,864 --> 01:17:16,000 CREATED A CHILLING EFFECT FOR 2156 01:17:16,000 --> 01:17:20,371 RESEARCHERS AT T -- THE EXTRAMUL 2157 01:17:20,371 --> 01:17:21,338 RESEARCHERS AT THE NIH, BOTH 2158 01:17:21,338 --> 01:17:23,941 EARLY STAGE AND LATER STAGE 2159 01:17:23,941 --> 01:17:26,110 INVESTIGATORS, AND WHAT WOULD BE 2160 01:17:26,110 --> 01:17:27,978 GREAT TO HELP IN TERMS OF 2161 01:17:27,978 --> 01:17:30,247 GETTING ON TRACK IS TO FOCUS ON 2162 01:17:30,247 --> 01:17:33,317 ACTUALLY NOT JUST THE EARLY 2163 01:17:33,317 --> 01:17:35,052 STAGE BUT TO THINK ABOUT THE 2164 01:17:35,052 --> 01:17:36,820 TRANSFORMATIVE RESEARCH AWARDS 2165 01:17:36,820 --> 01:17:39,156 AND PIONEER AWARDS IN TERMS OF 2166 01:17:39,156 --> 01:17:41,325 BEING AT ANY CAREER STAGE. 2167 01:17:41,325 --> 01:17:44,828 I THINK THAT IF WE TAKE THOSE 2168 01:17:44,828 --> 01:17:45,863 TWO SEPARATELY, ONE IS 2169 01:17:45,863 --> 01:17:47,932 ESSENTIALLY PIONEER AWARD IS 2170 01:17:47,932 --> 01:17:49,800 PERSON BASED AND THE OTHER, 2171 01:17:49,800 --> 01:17:50,768 TRANSFORMATIVE RESEARCH AWARD, 2172 01:17:50,768 --> 01:17:54,538 IS PROJECT BASED. 2173 01:17:54,538 --> 01:17:55,973 WHAT I THINK IS REALLY NEEDED 2174 01:17:55,973 --> 01:18:01,011 RIGHT NOW IS AN IDEA THAT YOU 2175 01:18:01,011 --> 01:18:04,415 CAN HELP WITH GIVEN TERMINATED 2176 01:18:04,415 --> 01:18:06,650 GRANTS AND OTHER CONCERNS THAT 2177 01:18:06,650 --> 01:18:09,053 HAVE BEEN REALLY DIFFICULT FOR 2178 01:18:09,053 --> 01:18:10,587 CURRENT EXTRAMURAL RESEARCHERS 2179 01:18:10,587 --> 01:18:11,822 FIGURE OUT IF THERE COULD BE AN 2180 01:18:11,822 --> 01:18:17,628 EXPANSION OF THIS PROGRAM TO GET 2181 01:18:17,628 --> 01:18:18,829 PEOPLE SORT OF MORE ON A PROJECT 2182 01:18:18,829 --> 01:18:20,397 BASED WAY FOR THE TRANSFORMATIVE 2183 01:18:20,397 --> 01:18:23,233 AND PIONEER FOR THE PERSON BASED 2184 01:18:23,233 --> 01:18:24,868 HELP GET BACK ON TRACK WITH 2185 01:18:24,868 --> 01:18:30,040 FUNDING. 2186 01:18:30,040 --> 01:18:32,443 SO I WOULD CERTAINLY SUPPORT 2187 01:18:32,443 --> 01:18:33,978 THIS BUT BEYOND SUPPORT THIS 2188 01:18:33,978 --> 01:18:37,047 HOPE THAT THERE IS EVEN 2189 01:18:37,047 --> 01:18:38,015 EXPANSION OF THOSE PARTICULAR 2190 01:18:38,015 --> 01:18:42,686 ONES WITH THE K AWARDS WITH THE 2191 01:18:42,686 --> 01:18:45,622 EARLY STAGE INVESTIGATOR, DP2s 2192 01:18:45,622 --> 01:18:48,025 HAVE BEEN INCREDIBLE TO -- IT 2193 01:18:48,025 --> 01:18:49,626 DOES TAKE AWAY YOUR EARLY CAREER 2194 01:18:49,626 --> 01:18:51,295 STATUS BUT YOU GET $200,000 A 2195 01:18:51,295 --> 01:18:53,597 YEAR WHICH IS KIND OF IN BETWEEN 2196 01:18:53,597 --> 01:18:55,599 A -- IT'S ESSENTIALLY NOT AS 2197 01:18:55,599 --> 01:18:58,135 MUCH AS A $500,000 A YEAR FOR AN 2198 01:18:58,135 --> 01:19:00,604 R01 BUT WE HAVE SEVERAL PEOPLE 2199 01:19:00,604 --> 01:19:04,274 THAT ARE DP2s IN THEIR -- BUT 2200 01:19:04,274 --> 01:19:05,943 IF WE COULD FOCUS ON ANY CAREER 2201 01:19:05,943 --> 01:19:08,012 STAGE AWARDS AND MAYBE ENHANCE 2202 01:19:08,012 --> 01:19:10,014 THOSE TO KIND OF HELP PEOPLE 2203 01:19:10,014 --> 01:19:11,115 WITH WHAT'S HAPPENING RIGHT NOW. 2204 01:19:11,115 --> 01:19:12,883 THANK YOU. 2205 01:19:12,883 --> 01:19:14,184 >> THANK YOU. 2206 01:19:14,184 --> 01:19:17,888 THAT'S A VERY IMPORTANT 2207 01:19:17,888 --> 01:19:18,422 OBSERVATION. 2208 01:19:18,422 --> 01:19:19,623 AFTER THE VOTE, OUR OFFICE 2209 01:19:19,623 --> 01:19:22,693 DIRECTOR IS GOING TO TALK ABOUT 2210 01:19:22,693 --> 01:19:26,163 SOME -- WELL, YOU'LL SEE SOME 2211 01:19:26,163 --> 01:19:29,933 MAYBE POTENTIAL IDEAS FOR 2212 01:19:29,933 --> 01:19:31,702 EXPANDING THE HRHR EFFORTS IN 2213 01:19:31,702 --> 01:19:32,369 OUR GROUP. 2214 01:19:32,369 --> 01:19:39,476 >> THANK YOU. 2215 01:19:39,476 --> 01:19:40,310 >> GREAT, THANK YOU. 2216 01:19:40,310 --> 01:19:41,912 WE'LL TURN IT OVER TO OTHER 2217 01:19:41,912 --> 01:19:43,213 COUNCILMEMBERS FOR QUESTIONS OR 2218 01:19:43,213 --> 01:19:47,151 COMMENTS, AND I SEE SOME HANDS 2219 01:19:47,151 --> 01:19:49,053 ALREADY BEING RAISED. 2220 01:19:49,053 --> 01:19:49,319 FRANZISKA? 2221 01:19:49,319 --> 01:19:50,521 >> I SEE RHONDA, YOUR HAND IS 2222 01:19:50,521 --> 01:19:51,155 UP. 2223 01:19:51,155 --> 01:19:54,691 WHY DON'T I GO TO YOU FIRST FOR 2224 01:19:54,691 --> 01:19:58,796 YOUR QUESTION OR COMMENT. 2225 01:19:58,796 --> 01:20:03,367 >> THANK YOU SO MUCH. 2226 01:20:03,367 --> 01:20:04,701 THANK YOU FOR THIS PRESENTATION. 2227 01:20:04,701 --> 01:20:05,669 CERTAINLY THIS IS ONE OF THE 2228 01:20:05,669 --> 01:20:07,471 HALL MARKS OF NIH INNOVATION AND 2229 01:20:07,471 --> 01:20:10,641 REALLY BEING ABLE TO PROMOTE 2230 01:20:10,641 --> 01:20:11,275 CREATIVITY IN THIS WAY. 2231 01:20:11,275 --> 01:20:17,314 I JUST HAVE A COUPLE QUESTIONS. 2232 01:20:17,314 --> 01:20:19,049 PART OF IT IS WHAT DR. MANLY 2233 01:20:19,049 --> 01:20:20,084 BROUGHT UP IN TERMS OF METRICS 2234 01:20:20,084 --> 01:20:21,085 TO SHOW SUCCESS. 2235 01:20:21,085 --> 01:20:22,286 GIVEN THE ENVIRONMENT AND 2236 01:20:22,286 --> 01:20:25,255 PARTICULARLY WITH CUTS TO NIH, 2237 01:20:25,255 --> 01:20:27,224 ARE THERE ANY CONSIDERATIONS AS 2238 01:20:27,224 --> 01:20:31,128 IT RELATES TO THE AREAS IN WHICH 2239 01:20:31,128 --> 01:20:32,863 INDIVIDUALS PLAN TO RESEARCH IN, 2240 01:20:32,863 --> 01:20:34,498 AND I BRING THAT UP FROM THE 2241 01:20:34,498 --> 01:20:38,001 STANDPOINT OF VIEW, CERTAINLY 2242 01:20:38,001 --> 01:20:38,969 SCIENTIFICALLY RELEVANT WAS A 2243 01:20:38,969 --> 01:20:44,575 TERM USED BUT ALSO HIGH RISK 2244 01:20:44,575 --> 01:20:45,142 SCIENCE TOO. 2245 01:20:45,142 --> 01:20:48,078 I'D LIKE TO BRING ANOTHER 2246 01:20:48,078 --> 01:20:50,614 CONSIDERATION HERE, AND THAT IS 2247 01:20:50,614 --> 01:20:54,151 THE AREAS WITHIN OUR HEALTHCARE 2248 01:20:54,151 --> 01:20:56,320 DELIVERY SYSTEM WHERE THERE'S 2249 01:20:56,320 --> 01:20:58,856 NEED FOR NEW INNOVATIVE WAYS OF 2250 01:20:58,856 --> 01:20:59,289 APPROACHING. 2251 01:20:59,289 --> 01:21:01,692 LET ME GIVE A SIMPLE EXAMPLE OF 2252 01:21:01,692 --> 01:21:03,494 ONE FROM INDIA, WHERE THE WISH 2253 01:21:03,494 --> 01:21:08,899 FOUNDATION ACTUALLY FUNDED, PUT 2254 01:21:08,899 --> 01:21:10,334 OUT RFIs, I GUESS YOU COULD 2255 01:21:10,334 --> 01:21:11,969 CALL THEM, OR GRANTS FOR 2256 01:21:11,969 --> 01:21:13,270 INNOVATORS TO COME UP WITH A WAY 2257 01:21:13,270 --> 01:21:15,506 TO DO MAMMOGRAMS SUCCESSFULLY 2258 01:21:15,506 --> 01:21:16,807 BUT AT A LOWER COST SINCE IT IS 2259 01:21:16,807 --> 01:21:19,810 A SCREENING MECHANISM THAT CAN 2260 01:21:19,810 --> 01:21:21,245 BE MORE APPLICABLE IF IT'S 2261 01:21:21,245 --> 01:21:24,181 SOMETHING THAT'S MORE 2262 01:21:24,181 --> 01:21:25,082 AFFORDABLE. 2263 01:21:25,082 --> 01:21:28,852 IS SO SO I'M JUST WONDERING WHER 2264 01:21:28,852 --> 01:21:29,586 NOT THERE ARE OTHER 2265 01:21:29,586 --> 01:21:30,787 CONSIDERATIONS OR THEMES THAT 2266 01:21:30,787 --> 01:21:35,125 WILL BE INTRODUCED IN THE 2267 01:21:35,125 --> 01:21:36,527 DECISIONS OF WHICH THINGS GO 2268 01:21:36,527 --> 01:21:37,394 FORWARD, RECOGNIZING THAT WE'RE 2269 01:21:37,394 --> 01:21:40,797 IN A SITUATION WHERE BUDGETS ARE 2270 01:21:40,797 --> 01:21:43,567 VERY IMPORTANT, BEING ABLE TO BE 2271 01:21:43,567 --> 01:21:45,202 COST-EFFECTIVE AS WELL AS 2272 01:21:45,202 --> 01:21:45,836 SCIENTIFICALLY EFFECTIVE. 2273 01:21:45,836 --> 01:21:49,506 THANK YOU. 2274 01:21:49,506 --> 01:21:52,543 >> THANK YOU, THAT'S A GOOD 2275 01:21:52,543 --> 01:21:53,844 QUESTION. 2276 01:21:53,844 --> 01:21:55,546 AS I MENTIONED, WE INVITE ALL 2277 01:21:55,546 --> 01:21:57,281 RESEARCH FROM ACROSS THE NIH 2278 01:21:57,281 --> 01:21:59,149 MISSION SPACE, AND OBVIOUSLY THE 2279 01:21:59,149 --> 01:22:00,384 AREAS YOU'RE CITING ARE WITHIN 2280 01:22:00,384 --> 01:22:02,352 THE NIH MISSION AND THEY WOULD 2281 01:22:02,352 --> 01:22:04,221 BE ENCOURAGED TO APPLY. 2282 01:22:04,221 --> 01:22:05,822 I CAN'T TELL YOU HOW MANY EMAILS 2283 01:22:05,822 --> 01:22:11,495 I GET ASKING WHETHER THIS AREA 2284 01:22:11,495 --> 01:22:13,497 OR THAT AREA IS ELIGIBLE AND THE 2285 01:22:13,497 --> 01:22:15,165 ANSWER IS ALMOST ALWAYS YES, 2286 01:22:15,165 --> 01:22:16,066 IT'S ELIGIBLE. 2287 01:22:16,066 --> 01:22:18,035 SO THEY'RE ALWAYS ELIGIBLE TO 2288 01:22:18,035 --> 01:22:18,902 APPLY. 2289 01:22:18,902 --> 01:22:23,073 THE CRITICAL THING FOR US IS 2290 01:22:23,073 --> 01:22:24,541 THEY MUST FAIR WELL IN PEER 2291 01:22:24,541 --> 01:22:24,975 REVIEW. 2292 01:22:24,975 --> 01:22:26,944 SO IF IT'S AN OUT THERE IDEA ON 2293 01:22:26,944 --> 01:22:29,112 AN AREA WE WOULD LIKE TO SUPPORT 2294 01:22:29,112 --> 01:22:31,682 BUT THEY DON'T DO WELL IN PEER 2295 01:22:31,682 --> 01:22:32,983 REVIEW, WE CAN'T DO ANYTHING 2296 01:22:32,983 --> 01:22:35,085 ABOUT THAT REALLY. 2297 01:22:35,085 --> 01:22:37,154 SO WE KEEP IT OPEN. 2298 01:22:37,154 --> 01:22:39,723 WE DON'T SPECIFY YOU WOULD LIKE 2299 01:22:39,723 --> 01:22:43,327 TO HAVE MAYBE HEALTHCARE 2300 01:22:43,327 --> 01:22:45,729 DELIVERY AREAS OF RESEARCH 2301 01:22:45,729 --> 01:22:46,997 EMPHASIZED, WE HAVE NOT DONE 2302 01:22:46,997 --> 01:22:47,764 THAT. 2303 01:22:47,764 --> 01:22:49,633 THERE ARE OTHER EFFORTS ACROSS 2304 01:22:49,633 --> 01:22:52,035 THE ICs IN MORE SPECIFIC AREAS 2305 01:22:52,035 --> 01:22:53,437 OF RESEARCH BY THE WAY THAT DO 2306 01:22:53,437 --> 01:22:54,271 THAT. 2307 01:22:54,271 --> 01:22:56,139 BUT I'M JUST TALKING ABOUT OUR 2308 01:22:56,139 --> 01:22:57,207 PROGRAM. 2309 01:22:57,207 --> 01:22:58,642 THE OTHER THING THAT'S IMPORTANT 2310 01:22:58,642 --> 01:23:02,946 TO NOTE IS IF THE APPLICATIONS 2311 01:23:02,946 --> 01:23:04,581 RECEIVE A SCORE, THEY GO THROUGH 2312 01:23:04,581 --> 01:23:08,652 A PROCESS CALLED PROGRAMMATIC 2313 01:23:08,652 --> 01:23:12,522 PRIORITY REVIEW AND THAT IS 2314 01:23:12,522 --> 01:23:13,090 WRITTEN OUT IN THE FUNDING 2315 01:23:13,090 --> 01:23:13,523 OPPORTUNITY. 2316 01:23:13,523 --> 01:23:16,893 ONE OF THE THINGS WE CAN 2317 01:23:16,893 --> 01:23:18,528 EMPHASIZE IS IF THE AREA OF 2318 01:23:18,528 --> 01:23:20,097 SCIENCE IS OUTSIDE WHAT WE'VE 2319 01:23:20,097 --> 01:23:24,368 FUNDED A LOT IN THE PAST, FOR 2320 01:23:24,368 --> 01:23:25,469 EXAMPLE, AND IF THERE IS 2321 01:23:25,469 --> 01:23:26,236 SOMETHING THAT RECEIVE AS SCORE 2322 01:23:26,236 --> 01:23:28,272 THAT MAYBE IS ON THE BORDER 2323 01:23:28,272 --> 01:23:30,207 BETWEEN LINES OF FUNDING OR NOT, 2324 01:23:30,207 --> 01:23:31,541 BUT IT'S SOMETHING WE'VE NEVER 2325 01:23:31,541 --> 01:23:34,745 SEEN BEFORE, AND WE NOTE AND THE 2326 01:23:34,745 --> 01:23:35,779 REVIEWERS NOTE THAT THIS GG TO 2327 01:23:35,779 --> 01:23:38,148 MAKE A HUGE IMPACT, WE CAN 2328 01:23:38,148 --> 01:23:39,650 SUPPORT THINGS LIKE THAT. 2329 01:23:39,650 --> 01:23:42,452 SO I THINK THAT'S AN IMPORTANT 2330 01:23:42,452 --> 01:23:46,056 ASPECT OF HOW WE TRY TO SPREAD 2331 01:23:46,056 --> 01:23:47,591 THE FUNDING TO REALLY COVER 2332 01:23:47,591 --> 01:23:51,228 EVERY AREA OF SCIENCE THAT IS 2333 01:23:51,228 --> 01:23:52,229 PEER-REVIEWED FAVORABLY. 2334 01:23:52,229 --> 01:23:53,997 BUT THAT PEER REVIEW IS 2335 01:23:53,997 --> 01:23:58,802 IMPORTANT, AND I'LL TELL YOU 2336 01:23:58,802 --> 01:23:59,936 THAT THAT'S YOU ALL OR YOUR 2337 01:23:59,936 --> 01:24:00,937 PEERS THAT ARE DOING THAT 2338 01:24:00,937 --> 01:24:01,271 REVIEW. 2339 01:24:01,271 --> 01:24:02,906 SO WE ARE BEHOLDEN TO THAT, AT 2340 01:24:02,906 --> 01:24:05,342 LEAST A LITTLE BIT. 2341 01:24:05,342 --> 01:24:09,446 DOES THAT ANSWER YOUR QUESTION? 2342 01:24:09,446 --> 01:24:10,147 >> YES, IT HAS. 2343 01:24:10,147 --> 01:24:10,947 THANK YOU SO MUCH. 2344 01:24:10,947 --> 01:24:12,115 I APPRECIATE YOUR RESPONSE. 2345 01:24:12,115 --> 01:24:12,616 >> GREAT. 2346 01:24:12,616 --> 01:24:13,617 THANK YOU VERY MUCH. 2347 01:24:13,617 --> 01:24:15,652 I SEE THREE MORE QUESTIONS OR 2348 01:24:15,652 --> 01:24:16,787 THREE MORE HANDS, AND, 2349 01:24:16,787 --> 01:24:18,588 THEREFORE, LET'S GO WITH THEM. 2350 01:24:18,588 --> 01:24:20,657 SO RAFAEL, YOU'RE FIRST, 2351 01:24:20,657 --> 01:24:25,896 FOLLOWED BY RUSS AND THEN JEN. 2352 01:24:25,896 --> 01:24:26,463 >> THANK YOU. 2353 01:24:26,463 --> 01:24:29,232 I AM FULLY SUPPORTIVE OF THIS, I 2354 01:24:29,232 --> 01:24:30,200 THINK THERE SHOULD BE EVEN MORE 2355 01:24:30,200 --> 01:24:31,468 FUNDING OF THESE KINDS OF 2356 01:24:31,468 --> 01:24:32,803 INITIATIVES COMPARED TO SOME OF 2357 01:24:32,803 --> 01:24:34,004 THE OTHER RESEARCH THAT IS 2358 01:24:34,004 --> 01:24:36,740 FUNDED BY THE NIH. 2359 01:24:36,740 --> 01:24:41,411 PLY QUESTMY QUESTION IS IF EVERY 2360 01:24:41,411 --> 01:24:42,012 INSTITUTION -- RESEARCH 2361 01:24:42,012 --> 01:24:44,581 INSTITUTION IS GOING TO BE -- IS 2362 01:24:44,581 --> 01:24:45,816 THIS GOING TO BE AVAILABLE TO 2363 01:24:45,816 --> 01:24:47,351 ALL RESEARCH INSTITUTIONS? 2364 01:24:47,351 --> 01:24:49,219 AND IF NOT, WHAT ARE THE 2365 01:24:49,219 --> 01:24:52,556 CRITERIA TO EXCLUDE THEM AND HOW 2366 01:24:52,556 --> 01:24:55,892 WILL THEY KNOW IN ADVANCE SO 2367 01:24:55,892 --> 01:24:57,361 THEY CANNOT APPLY OR SPEND TIME 2368 01:24:57,361 --> 01:24:57,627 APPLYING? 2369 01:24:57,627 --> 01:24:59,830 >> I'M SORRY I DIDN'T MAKE THAT 2370 01:24:59,830 --> 01:25:00,497 CLEAR EARLIER. 2371 01:25:00,497 --> 01:25:03,867 THIS IS OPEN TO ALL ELIGIBLE 2372 01:25:03,867 --> 01:25:04,668 INSTITUTIONS. 2373 01:25:04,668 --> 01:25:06,536 SO ANY INSTITUTION THAT CAN 2374 01:25:06,536 --> 01:25:09,172 APPLY FOR R01s, THAT THEY 2375 01:25:09,172 --> 01:25:10,607 WOULD BE ELIGIBLE. 2376 01:25:10,607 --> 01:25:16,546 THERE'S NO LIMITATIONS ON THAT. 2377 01:25:16,546 --> 01:25:18,181 >> GREAT, THANK YOU, PAT. 2378 01:25:18,181 --> 01:25:18,548 RUSS. 2379 01:25:18,548 --> 01:25:18,982 >> GREAT. 2380 01:25:18,982 --> 01:25:19,850 THANK YOU. 2381 01:25:19,850 --> 01:25:21,918 I'M ALSO VERY SUPPORTIVE OF 2382 01:25:21,918 --> 01:25:24,921 THESE PROGRAMS. 2383 01:25:24,921 --> 01:25:27,457 BOTH IN THE LAST CONCEPT 2384 01:25:27,457 --> 01:25:28,325 CLEARANCE AND THIS ONE, THE 2385 01:25:28,325 --> 01:25:31,027 QUESTION HAS COME UP AS TO HOW 2386 01:25:31,027 --> 01:25:32,829 WE MEASURE SUCCESS AND WHAT 2387 01:25:32,829 --> 01:25:34,030 THOSE KEY PERFORMANCE INDICATORS 2388 01:25:34,030 --> 01:25:36,433 ARE. 2389 01:25:36,433 --> 01:25:37,634 WE HAVE A NATURAL EXPERIMENT 2390 01:25:37,634 --> 01:25:39,603 WHICH IS THAT YOU HAVE MANY 2391 01:25:39,603 --> 01:25:41,071 INDIVIDUALS WHO APPLY FOR THESE 2392 01:25:41,071 --> 01:25:44,674 AWARDS AND ARE NOT GRANTED THEM. 2393 01:25:44,674 --> 01:25:47,277 AND IN PARTICULAR, STUDY SECTION 2394 01:25:47,277 --> 01:25:49,479 IS RANKING THESE APPLICATIONS 2395 01:25:49,479 --> 01:25:51,314 AND THERE'S A CUTOFF LINE, 2396 01:25:51,314 --> 01:25:54,484 THERE'S SOME FUNDING LINE, AND 2397 01:25:54,484 --> 01:25:55,752 THE FOLKS WHO WERE JUST BELOW 2398 01:25:55,752 --> 01:25:56,920 AND JUST ABOVE THAT FUNDING LINE 2399 01:25:56,920 --> 01:25:57,954 SORT OF MAKE A NATURAL 2400 01:25:57,954 --> 01:25:59,456 EXPERIMENT TO SAY WHAT WOULD 2401 01:25:59,456 --> 01:26:00,390 HAPPEN IF YOU DIDN'T HAVE 2402 01:26:00,390 --> 01:26:03,026 SUPPORT OF THIS PROGRAM. 2403 01:26:03,026 --> 01:26:06,430 IS THERE ANY CONSIDERATION 2404 01:26:06,430 --> 01:26:08,498 INSTEAD OF JUST LISTING THE 2405 01:26:08,498 --> 01:26:09,866 ACCOMPLISHMENTS OF THE AWARDEES, 2406 01:26:09,866 --> 01:26:10,834 PARTICULARLY FOR THOSE EARLY 2407 01:26:10,834 --> 01:26:13,703 CAREER AWARDS, OF ACTUALLY 2408 01:26:13,703 --> 01:26:15,672 ASKING HOW DID THEIR CAREER 2409 01:26:15,672 --> 01:26:16,506 TRAJECTORIES COMPARE WITH THOSE 2410 01:26:16,506 --> 01:26:21,077 WHO DID NOT -- WHO WERE NOT 2411 01:26:21,077 --> 01:26:23,480 AWARDED THESE PARTICULAR 2412 01:26:23,480 --> 01:26:24,481 MECHANISMS? 2413 01:26:24,481 --> 01:26:31,521 >> WELL, AS BECKY OUTLINED, WHAT 2414 01:26:31,521 --> 01:26:32,856 WE'VE DONE IN THE PAST IS 2415 01:26:32,856 --> 01:26:35,759 COMPARE OUR AWARD RECIPIENTS TO 2416 01:26:35,759 --> 01:26:36,626 R01 AWARD RECIPIENTS. 2417 01:26:36,626 --> 01:26:38,829 NOW, I'VE NEVER GONE THROUGH AND 2418 01:26:38,829 --> 01:26:39,696 LOOKED AT WHETHER OR NOT THE 2419 01:26:39,696 --> 01:26:43,366 PEOPLE THAT ARE ON THAT LINE 2420 01:26:43,366 --> 01:26:47,204 RECEIVED AN R01 IN THE SAME 2421 01:26:47,204 --> 01:26:48,605 COMPETITION YEAR, IF THEY EXIST, 2422 01:26:48,605 --> 01:26:51,374 I THINK THAT WOULD BE VERY FEW. 2423 01:26:51,374 --> 01:26:54,044 I DON'T THINK IT'S FAIR TO 2424 01:26:54,044 --> 01:26:55,545 COMPARE AWARDEES AND 2425 01:26:55,545 --> 01:26:56,980 NON-AWARDEES IF THOSE 2426 01:26:56,980 --> 01:26:58,114 NON-AWARDEES DIDN'T GET ANY 2427 01:26:58,114 --> 01:26:58,882 FUNDING, RIGHT? 2428 01:26:58,882 --> 01:27:00,317 I THINK WE KNOW WHAT MIGHT 2429 01:27:00,317 --> 01:27:03,487 HAPPEN TO THEM. 2430 01:27:03,487 --> 01:27:05,121 WE CAN DO THAT, I SUPPOSE, IT 2431 01:27:05,121 --> 01:27:06,289 WOULDN'T BE HARD, BUT WE HAVE 2432 01:27:06,289 --> 01:27:06,590 NOT. 2433 01:27:06,590 --> 01:27:08,325 I DON'T KNOW, BECKY, DO YOU WANT 2434 01:27:08,325 --> 01:27:09,793 TO ADD IN ON THAT? 2435 01:27:09,793 --> 01:27:13,129 >> WE DID LOOK AT THOSE WHO WERE 2436 01:27:13,129 --> 01:27:14,431 SCORED BUT WERE NOT ULTIMATELY 2437 01:27:14,431 --> 01:27:18,201 FUNDED FOR THE PIONEER 2438 01:27:18,201 --> 01:27:18,768 EVALUATION. 2439 01:27:18,768 --> 01:27:21,471 BUT WE HAVEN'T -- THERE WERE 2440 01:27:21,471 --> 01:27:22,839 PROBLEM WITH THAT COMPARISON, SO 2441 01:27:22,839 --> 01:27:24,975 IN THE FUTURE, WHEN WE LOOKED TO 2442 01:27:24,975 --> 01:27:26,142 OTHER INITIATIVES, WE OPTED NOT 2443 01:27:26,142 --> 01:27:28,645 TO USE THAT POOL AS THE 2444 01:27:28,645 --> 01:27:31,281 COMPARATOR, JUST BECAUSE IT 2445 01:27:31,281 --> 01:27:34,718 WASN'T DEEMED FAIR COMPARISON. 2446 01:27:34,718 --> 01:27:37,020 >> AS OTHERS HAVE MENTIONED, IF 2447 01:27:37,020 --> 01:27:39,122 WE'RE GOING INTO AN AUSTERE 2448 01:27:39,122 --> 01:27:42,125 PERIOD OF FUNDING, DEMONSTRATING 2449 01:27:42,125 --> 01:27:44,528 VALUE FOR THE EXISTING FUNDING 2450 01:27:44,528 --> 01:27:45,762 MECHANISMS IS GOING TO BECOME 2451 01:27:45,762 --> 01:27:48,532 EVEN MORE IMPORTANT, AND THERE'S 2452 01:27:48,532 --> 01:27:50,100 A LITTLE BIT OF AN INTRINSIC 2453 01:27:50,100 --> 01:27:51,835 BIAS HERE THAT YOUR MOST 2454 01:27:51,835 --> 01:27:52,702 OUTSTANDING CANDIDATES ARE 2455 01:27:52,702 --> 01:27:54,437 LIKELY TO WIN THESE AWARDS, AND 2456 01:27:54,437 --> 01:27:55,739 THEY'RE MOST LIKELY TO SUCCEED 2457 01:27:55,739 --> 01:27:57,908 IN ANY CASE AND SO TO SOME 2458 01:27:57,908 --> 01:28:01,611 EXTENT, I THINK -- TO THE EXTENT 2459 01:28:01,611 --> 01:28:03,146 THAT WE CAN DEMONSTRATE THE TRUE 2460 01:28:03,146 --> 01:28:05,215 VALUE OF THESE MECHANISMS TO A 2461 01:28:05,215 --> 01:28:06,349 BROAD AUDIENCE, I THINK THAT'S 2462 01:28:06,349 --> 01:28:08,351 GOING TO BE ESSENTIAL. 2463 01:28:08,351 --> 01:28:10,320 >> IT AN INTERESTING IDEA. 2464 01:28:10,320 --> 01:28:11,087 I'LL TAKE THAT BACK AND WE'LL 2465 01:28:11,087 --> 01:28:11,655 THINK ABOUT IT. 2466 01:28:11,655 --> 01:28:13,723 I DON'T THINK THAT WAS THE BIAS 2467 01:28:13,723 --> 01:28:17,460 I WAS INTENDED TO COMMUNICATE. 2468 01:28:17,460 --> 01:28:18,228 MY POINT WAS THAT IT'S NOT 2469 01:28:18,228 --> 01:28:19,829 REALLY FAIR TO COMPARE A GROUP 2470 01:28:19,829 --> 01:28:21,231 THAT RECEIVED FUNDS AND ONE THAT 2471 01:28:21,231 --> 01:28:24,734 DID NOT RECEIVE FUNDS. 2472 01:28:24,734 --> 01:28:26,036 I THINK A LITTLE COMMON SENSE 2473 01:28:26,036 --> 01:28:27,003 KNOWS THAT THAT'S GOING TO 2474 01:28:27,003 --> 01:28:30,507 IMPACT THEIR CAREER. 2475 01:28:30,507 --> 01:28:31,708 BUT I LIKE WHAT YOU'RE SAYING 2476 01:28:31,708 --> 01:28:34,010 AND WE'LL TI TAKE THAT BACK AND 2477 01:28:34,010 --> 01:28:34,377 THINK ABOUT IT. 2478 01:28:34,377 --> 01:28:34,811 THANK YOU. 2479 01:28:34,811 --> 01:28:35,512 >> THANK YOU. 2480 01:28:35,512 --> 01:28:38,915 SO WE'LL GO LAST TO JEN AND THEN 2481 01:28:38,915 --> 01:28:40,517 A SHORT ANSWER MAYBE. 2482 01:28:40,517 --> 01:28:43,520 >> SO THIS IS A QUICK COMMENT 2483 01:28:43,520 --> 01:28:46,456 AND A QUESTION, SO THE COMMENT 2484 01:28:46,456 --> 01:28:47,991 IS YOU GOT A QUESTION EARLIER 2485 01:28:47,991 --> 01:28:49,793 ABOUT WHETHER THE AWARDS ARE 2486 01:28:49,793 --> 01:28:52,395 AVAILABLE FOR ALL INSTITUTIONS. 2487 01:28:52,395 --> 01:28:56,333 AND I'M ALSO SURE THAT THE 2488 01:28:56,333 --> 01:28:59,235 INTENTION IS TO SUPPORT SCIENCE 2489 01:28:59,235 --> 01:29:04,274 THAT SUPPORTS -- OR THAT WOULD 2490 01:29:04,274 --> 01:29:07,344 PROVIDE HELP FOR ALL AMERICANS. 2491 01:29:07,344 --> 01:29:14,618 SO ON A QUICK SEARCH OF THE TAGS 2492 01:29:14,618 --> 01:29:15,819 LIST, WHICH ARE CANCELED GRANTS 2493 01:29:15,819 --> 01:29:17,654 OVER THE WEEKEND, I FOUND THAT 2494 01:29:17,654 --> 01:29:19,889 FIVE OF THESE AWARDS, AT LEAST 2495 01:29:19,889 --> 01:29:23,526 FIVE, HAVE BEEN CANCELED 2496 01:29:23,526 --> 01:29:25,395 RECENTLY OF THE HIGH RISK, HIGH 2497 01:29:25,395 --> 01:29:25,929 REWARD PROGRAMS. 2498 01:29:25,929 --> 01:29:27,464 SO THAT'S MY COMMENT. 2499 01:29:27,464 --> 01:29:32,168 MY QUESTION IS, JUST LIKE RAFAEL 2500 01:29:32,168 --> 01:29:34,904 ASKED WHETHER THE AWARDS WILL BE 2501 01:29:34,904 --> 01:29:39,976 AVAILABLE TO ALL INSTITUTIONS, 2502 01:29:39,976 --> 01:29:42,045 WILL THE AWARDS BE AVAILABLE TO 2503 01:29:42,045 --> 01:29:45,248 ALL SCIENTIFIC TOPICS? 2504 01:29:45,248 --> 01:29:47,651 >> SO AS I STATED BEFORE, 2505 01:29:47,651 --> 01:29:49,219 THEY'RE OPEN TO EVERYTHING 2506 01:29:49,219 --> 01:29:53,056 WITHIN THE NIH MISSION SPACE. 2507 01:29:53,056 --> 01:29:55,125 IF THERE ARE AREAS OF SCIENCE 2508 01:29:55,125 --> 01:29:56,760 THAT BY NIH POLICY WE ARE NOT 2509 01:29:56,760 --> 01:29:58,895 GOING TO SUPPORT, THEN THOSE 2510 01:29:58,895 --> 01:30:07,137 PROBABLY WILL NOT BE SUPPORTED. 2511 01:30:07,137 --> 01:30:07,904 >> OKAY, THANK YOU. 2512 01:30:07,904 --> 01:30:08,905 >> SORRY. 2513 01:30:08,905 --> 01:30:10,507 >> ALL RIGHT. 2514 01:30:10,507 --> 01:30:12,676 SO WITH THAT COMMENT, I THINK WE 2515 01:30:12,676 --> 01:30:15,412 CAN MOVE ON TO THE VOTE ON THIS 2516 01:30:15,412 --> 01:30:15,979 CONCEPT. 2517 01:30:15,979 --> 01:30:20,884 AND THEN AS ALREADY ALLUDED TO, 2518 01:30:20,884 --> 01:30:22,852 CAROLYN HUTTER WILL FOLLOW WITH 2519 01:30:22,852 --> 01:30:24,287 A DISCUSSION TO THE FUTURE. 2520 01:30:24,287 --> 01:30:25,655 WE DISCUSSED ON OUR END HOW WE 2521 01:30:25,655 --> 01:30:26,856 SHOULD DO THE VOTE. 2522 01:30:26,856 --> 01:30:28,158 WE ARE GOING TO CONTINUE WITH 2523 01:30:28,158 --> 01:30:31,027 THIS HAND RAISING METHOD BECAUSE 2524 01:30:31,027 --> 01:30:32,595 WE BELIEVE THAT IS A BETTER 2525 01:30:32,595 --> 01:30:35,231 OUTCOME. 2526 01:30:35,231 --> 01:30:37,300 LET ME FIRST CALL FOR THE MOTION 2527 01:30:37,300 --> 01:30:39,235 AND THEN I'LL HAND IT OVER TO 2528 01:30:39,235 --> 01:30:41,104 CHRISTINA FOR THE ACTUAL VOTE. 2529 01:30:41,104 --> 01:30:44,040 MAY I HAVE A MOTION FOR APPROVAL 2530 01:30:44,040 --> 01:30:48,511 OF THE OFFICE OF SCIENCE -- OSC 2531 01:30:48,511 --> 01:30:49,913 CONCEPT CLEARANCE ENTITLED HIGH 2532 01:30:49,913 --> 01:30:52,115 RISK, HIGH REWARD HRHR RESEARCH 2533 01:30:52,115 --> 01:30:53,183 PROGRAM. 2534 01:30:53,183 --> 01:30:54,551 IS THERE SUCH A MOTION? 2535 01:30:54,551 --> 01:30:56,419 I SEE SO MOVED. 2536 01:30:56,419 --> 01:30:57,153 I SEE SECOND. 2537 01:30:57,153 --> 01:30:57,921 THANK YOU VERY MUCH. 2538 01:30:57,921 --> 01:30:59,689 IS THERE ANY MORE DISCUSSION AT 2539 01:30:59,689 --> 01:31:06,563 THIS POINT? 2540 01:31:06,563 --> 01:31:08,198 I SEE NO MORE RAISED HANDS, 2541 01:31:08,198 --> 01:31:09,299 NOTHING IN THE CHAT. 2542 01:31:09,299 --> 01:31:11,134 WITH THAT, I'LL TURN IT OVER TO 2543 01:31:11,134 --> 01:31:16,706 CHRISCHRISTINA. 2544 01:31:16,706 --> 01:31:23,279 >> NO, I WAS VOTING, SORRY. 2545 01:31:23,279 --> 01:31:24,814 >> IT'S ALWAYS GOOD TO HAVE 2546 01:31:24,814 --> 01:31:26,049 MULTIPLE EYES LOOKING. 2547 01:31:26,049 --> 01:31:26,716 CHRISTINA, GO AHEAD. 2548 01:31:26,716 --> 01:31:28,151 >> THANK YOU, DR. GRIEDER. 2549 01:31:28,151 --> 01:31:30,720 AS MENTIONED, THIS IS A VOTE FOR 2550 01:31:30,720 --> 01:31:32,455 APPROVAL OF THE OSC CONCEPT 2551 01:31:32,455 --> 01:31:36,025 CLEARANCE TITLED HIGH RISK, HIGH 2552 01:31:36,025 --> 01:31:38,428 REWARD RESEARCH PROGRAM. 2553 01:31:38,428 --> 01:31:39,529 PLEASE RAISE YOUR HAND TO VOTE 2554 01:31:39,529 --> 01:31:42,699 AYE FOR THE PRESENTED CONCEPT 2555 01:31:42,699 --> 01:31:53,042 FLEURCHLT THANK YOU. 2556 01:31:53,243 --> 01:31:54,811 THANK YOU. 2557 01:31:54,811 --> 01:32:01,050 I SEE 16 RAISED HANDS. 2558 01:32:01,050 --> 01:32:03,553 PLEASE LOWER YOUR HANDS. 2559 01:32:03,553 --> 01:32:04,854 AND WE WILL MOVE ON TO THE NEXT 2560 01:32:04,854 --> 01:32:13,062 VOTE. 2561 01:32:13,062 --> 01:32:13,663 PLEASE LOWER YOUR HANDS. 2562 01:32:13,663 --> 01:32:14,597 THANK YOU. 2563 01:32:14,597 --> 01:32:16,332 PLEASE RAISE YOUR HAND TO VOTE 2564 01:32:16,332 --> 01:32:25,275 NAY FOR THE PRESENTED CONCEPT. 2565 01:32:25,275 --> 01:32:25,909 THANK YOU. 2566 01:32:25,909 --> 01:32:27,477 I DO NOT SEE ANY RAISED HANDS. 2567 01:32:27,477 --> 01:32:28,578 MOVING ALONG, PLEASE LOWER YOUR 2568 01:32:28,578 --> 01:32:30,780 HANDS IF THEY WERE RAISED. 2569 01:32:30,780 --> 01:32:32,215 MOVING ALONG, PLEASE RAISE YOUR 2570 01:32:32,215 --> 01:32:33,917 HAND TO VOTE ABSTENTION FOR THE 2571 01:32:33,917 --> 01:32:40,590 PRESENTED CONCEPT. 2572 01:32:40,590 --> 01:32:43,760 NOT SEEING ANY RAISED HANDS, THE 2573 01:32:43,760 --> 01:32:44,861 MOTION AS STATED HAS PASSED. 2574 01:32:44,861 --> 01:32:45,361 THANK YOU. 2575 01:32:45,361 --> 01:32:47,096 >> THANK YOU, CHRISTINA. 2576 01:32:47,096 --> 01:32:47,897 NICOLE? 2577 01:32:47,897 --> 01:32:50,500 >> THANK YOU ALL. 2578 01:32:50,500 --> 01:32:51,267 OKAY. 2579 01:32:51,267 --> 01:32:53,837 MOVING TO THE NEXT SECTION. 2580 01:32:53,837 --> 01:32:57,574 SO ONE OF NIH'S AND ESPECIALLY 2581 01:32:57,574 --> 01:33:00,043 DPCPSI'S KEY GOALS IS TO FOSTER 2582 01:33:00,043 --> 01:33:01,344 FUNDAMENTAL CREATIVE DISCOVERIES 2583 01:33:01,344 --> 01:33:02,445 IN INNOVATIVE RESEARCH 2584 01:33:02,445 --> 01:33:03,012 STRATEGIES. 2585 01:33:03,012 --> 01:33:06,249 SO ACHIEVING THIS REQUIRES A 2586 01:33:06,249 --> 01:33:07,584 RANGE OF APPROACHES INCLUDING 2587 01:33:07,584 --> 01:33:08,885 IDENTIFYING AND SUPPORTING 2588 01:33:08,885 --> 01:33:10,420 RESEARCH THAT HAS THE POTENTIAL 2589 01:33:10,420 --> 01:33:12,589 TO DISRUPT CURRENT BIOMEDICAL 2590 01:33:12,589 --> 01:33:14,657 PARADIGMS AND OPEN NEW PATHWAYS 2591 01:33:14,657 --> 01:33:15,525 FOR DISEASE PREVENTION, 2592 01:33:15,525 --> 01:33:16,759 DIAGNOSIS AND TREATMENT. 2593 01:33:16,759 --> 01:33:19,229 SO THIS TRANSFORMATIVE RESEARCH 2594 01:33:19,229 --> 01:33:20,430 OFTEN INCLUDES CREATIVE 2595 01:33:20,430 --> 01:33:21,731 APPROACHES AND SUBSTANTIAL BREAK 2596 01:33:21,731 --> 01:33:23,032 THROUGHS THAT CHALLENGE NORMS 2597 01:33:23,032 --> 01:33:24,200 AND ARISE FROM NOVEL IDEAS ON 2598 01:33:24,200 --> 01:33:25,835 THE EDGES OR INTERSECTIONS OF 2599 01:33:25,835 --> 01:33:28,571 DISCIPLINES. 2600 01:33:28,571 --> 01:33:31,174 SO TRANSFORMATIVE RESEARCH 2601 01:33:31,174 --> 01:33:32,208 INHERENTLY INVOLVES A LEVEL OF 2602 01:33:32,208 --> 01:33:34,010 RISK AND UNCERTAINTY AS ALSO HAS 2603 01:33:34,010 --> 01:33:35,378 POTENTIAL FOR EXCEPTIONALLY HIGH 2604 01:33:35,378 --> 01:33:35,712 IMPACT. 2605 01:33:35,712 --> 01:33:37,013 SO AS A RESULT, THESE HIGH RISK 2606 01:33:37,013 --> 01:33:38,214 HIGH REWARD INITIATIVES THAT 2607 01:33:38,214 --> 01:33:40,049 ALLOW FOR INCREASED INNOVATION 2608 01:33:40,049 --> 01:33:41,985 AND EXPERIMENTATION CAN IDEALLY 2609 01:33:41,985 --> 01:33:44,387 LEAD TO GROUNDBREAKING 2610 01:33:44,387 --> 01:33:45,255 DISCOVERIES, ADDRESS CHALLENGING 2611 01:33:45,255 --> 01:33:46,389 QUESTIONS AND CATALYZE 2612 01:33:46,389 --> 01:33:48,758 SCIENTIFIC PROGRESS. 2613 01:33:48,758 --> 01:33:50,159 SO THERE IS OPPORTUNITY FOR 2614 01:33:50,159 --> 01:33:51,794 DPCPSI TO BUILD ON THE SUCCESS 2615 01:33:51,794 --> 01:33:54,197 OF THE PROGRAMS SUCH AS THOSE 2616 01:33:54,197 --> 01:33:56,599 THAT YOU JUST HEARD ABOUT, AND 2617 01:33:56,599 --> 01:33:58,434 WE ARE TRYING TO EXAMINE 2618 01:33:58,434 --> 01:33:59,402 ADDITIONAL WAYS THAT DPCPSI 2619 01:33:59,402 --> 01:34:00,603 COULD ADVANCE NOVEL APPROACHES 2620 01:34:00,603 --> 01:34:02,572 AND OUTCOMES WORKING IN 2621 01:34:02,572 --> 01:34:03,940 PARTNERSHIP ACROSS ALL OF OUR 2622 01:34:03,940 --> 01:34:05,241 NIH INSTITUTES, CENTERS AND 2623 01:34:05,241 --> 01:34:06,342 OFFICES. 2624 01:34:06,342 --> 01:34:08,211 SO WE THINK THAT THERE IS SPACE 2625 01:34:08,211 --> 01:34:10,480 FOR MORE STRATEGIC OPPORTUNITY 2626 01:34:10,480 --> 01:34:12,115 TARGETED ON HOW WE CAN IMPROVE 2627 01:34:12,115 --> 01:34:13,850 AND EXPAND ON OUR EXISTING 2628 01:34:13,850 --> 01:34:15,184 EFFORTS, SO WE HAVE A PROPOSAL 2629 01:34:15,184 --> 01:34:17,120 ON HOW WE MIGHT DO THAT, WHICH 2630 01:34:17,120 --> 01:34:18,321 WE WOULD CERTAINLY APPRECIATE 2631 01:34:18,321 --> 01:34:20,490 YOUR THOUGHTS ON AND CAROLYN 2632 01:34:20,490 --> 01:34:21,491 WILL ELABORATE FURTHER. 2633 01:34:21,491 --> 01:34:22,659 SO WITH THAT, CAROLYN, THE FLOOR 2634 01:34:22,659 --> 01:34:25,995 IS YOURS. 2635 01:34:25,995 --> 01:34:26,596 >> THANK YOU. 2636 01:34:26,596 --> 01:34:28,031 AND THANK YOU, EVERYBODY, FOR 2637 01:34:28,031 --> 01:34:28,564 JOINING US THIS MORNING. 2638 01:34:28,564 --> 01:34:29,766 I'M VERY EXCITED THAT WE WERE 2639 01:34:29,766 --> 01:34:32,502 ABLE TO HAVE THIS COUNCIL OF 2640 01:34:32,502 --> 01:34:33,903 COUNCILS MEETING SCHEDULE. 2641 01:34:33,903 --> 01:34:34,904 SO AGAIN FOR THOSE OF WHO YOU 2642 01:34:34,904 --> 01:34:36,739 DON'T KNOW ME, I AM THE OFFICE 2643 01:34:36,739 --> 01:34:38,675 DIRECTOR FOR THE OFFICE OF 2644 01:34:38,675 --> 01:34:40,510 STRATEGIC COORDINATION, AND WHAT 2645 01:34:40,510 --> 01:34:44,013 I'M PRESENTING TODAY IS A 2646 01:34:44,013 --> 01:34:46,015 PROPOSAL FOR AN HRHR WORKING 2647 01:34:46,015 --> 01:34:47,283 GROUP OF THE COUNCIL OF COUNCILS 2648 01:34:47,283 --> 01:34:51,354 AND IF YOU GO TO THE NEXT SLIDE, 2649 01:34:51,354 --> 01:34:52,655 PLEASE, WE'RE WANTING TO FOCUS 2650 01:34:52,655 --> 01:34:54,290 THIS ON TRANSFORMATIONAL 2651 01:34:54,290 --> 01:34:55,258 BIOMEDICAL RESEARCH, AND I WILL 2652 01:34:55,258 --> 01:34:56,926 SAY THAT THE DISCUSSION THAT YOU 2653 01:34:56,926 --> 01:35:01,597 ALL JUST HAD AFTER TRISH AND 2654 01:35:01,597 --> 01:35:02,465 BECKY'S PRESENTATION REALLY SETS 2655 01:35:02,465 --> 01:35:04,634 THE STAGE FOR WHY WE THINK A 2656 01:35:04,634 --> 01:35:06,169 WORKING GROUP IN THIS AREA AT 2657 01:35:06,169 --> 01:35:07,670 THIS TIME WOULD BE IMPORTANT. 2658 01:35:07,670 --> 01:35:10,974 AS NICOLE JUST LAID OUT, THIS 2659 01:35:10,974 --> 01:35:13,142 WORKING GROUP WOULD BE BROADER 2660 01:35:13,142 --> 01:35:15,311 THAN AN ANALYSIS OF THE EXISTING 2661 01:35:15,311 --> 01:35:17,046 HRHR PROGRAMS AND REALLY LOOK AT 2662 01:35:17,046 --> 01:35:19,048 HOW DO WE THINK ABOUT INNOVATIVE 2663 01:35:19,048 --> 01:35:20,683 RESEARCH THAT GOES BEYOND 2664 01:35:20,683 --> 01:35:21,784 INCREMENTAL ADVANCES AND 2665 01:35:21,784 --> 01:35:23,286 CREATIVE APPROACHES IN THIS 2666 01:35:23,286 --> 01:35:25,121 SPACE, AND REALLY COME AFTER THE 2667 01:35:25,121 --> 01:35:26,889 CHALLENGES ABOUT HOW DO WE 2668 01:35:26,889 --> 01:35:27,991 IDENTIFY CRITICAL TOPICS AND 2669 01:35:27,991 --> 01:35:29,492 APPROACHES WITH POTENTIAL 2670 01:35:29,492 --> 01:35:30,927 IMPACT, HOW DO WE DEVELOP 2671 01:35:30,927 --> 01:35:32,228 APPROPRIATE MECHANISMS AND 2672 01:35:32,228 --> 01:35:34,030 REVIEW PROCESSES, AND BUILDING 2673 01:35:34,030 --> 01:35:35,665 ON THE DISCUSSION WE JUST HAD 2674 01:35:35,665 --> 01:35:37,133 AND CERTAINLY PART OF OUR 2675 01:35:37,133 --> 01:35:37,934 CONSIDERATION IN THINKING ABOUT 2676 01:35:37,934 --> 01:35:39,769 THIS WORKING GROUP, ALTHOUGH NOT 2677 01:35:39,769 --> 01:35:41,170 LISTED ON THIS SLIDE, IS ALSO 2678 01:35:41,170 --> 01:35:42,705 HOW DO WE EVALUATE SUCCESS. 2679 01:35:42,705 --> 01:35:45,141 WHAT ARE THE APPROPRIATE 2680 01:35:45,141 --> 01:35:48,177 METRICS, AND THE WAYS TO SORT OF 2681 01:35:48,177 --> 01:35:50,146 STUDY WHEN ARE WE HAVING SUCCESS 2682 01:35:50,146 --> 01:35:51,547 AND WHAT OPPORTUNITIES LEAD TO 2683 01:35:51,547 --> 01:35:56,486 SUCCESS IN THIS AREA. 2684 01:35:56,486 --> 01:35:57,687 SO AS WE THINK OF THE WORKING 2685 01:35:57,687 --> 01:35:59,756 GROUP OF THIS COUNCIL, WHAT WE 2686 01:35:59,756 --> 01:36:01,824 WOULD HOPE THAT WE WOULD BE ABLE 2687 01:36:01,824 --> 01:36:03,993 TO COME TOGETHER WITH A GROUP TO 2688 01:36:03,993 --> 01:36:08,598 DISCUSS IS HOW DO WE BEST FOSTER 2689 01:36:08,598 --> 01:36:11,534 TRANSFORMATIVE BIOMEDICAL 2690 01:36:11,534 --> 01:36:14,704 RESEARCH, NOT JUST I IN DPCPSI T 2691 01:36:14,704 --> 01:36:15,371 ACROSS NIH. 2692 01:36:15,371 --> 01:36:17,006 WHAT'S THE APPROPRIATE PORTFOLIO 2693 01:36:17,006 --> 01:36:18,007 BALANCE FOR THESE TYPES OF 2694 01:36:18,007 --> 01:36:19,375 EFFORTS LIKE I JUST HEARD SOME 2695 01:36:19,375 --> 01:36:20,176 OF THE FEEDBACK THAT MAYBE WE 2696 01:36:20,176 --> 01:36:21,377 SHOULD THINK ABOUT INCREASING 2697 01:36:21,377 --> 01:36:22,678 WHAT PORTION OF OUR PORTFOLIO 2698 01:36:22,678 --> 01:36:25,748 GOES TO THESE TYPES OF EFFORTS, 2699 01:36:25,748 --> 01:36:28,584 HOW DO WE ASSESS THAT, HOW DO WE 2700 01:36:28,584 --> 01:36:29,552 ASSESS WHETHER WE'RE TAKING 2701 01:36:29,552 --> 01:36:30,820 APPROPRIATE RISK, HOW DO WE 2702 01:36:30,820 --> 01:36:32,155 ASSESS WHETHER WE'RE HAVING 2703 01:36:32,155 --> 01:36:35,525 APPROPRIATE SUCCESS. 2704 01:36:35,525 --> 01:36:36,859 HOW DO WE BROADEN THE 2705 01:36:36,859 --> 01:36:38,227 PARTICIPATION, REALLY YOU GUYS 2706 01:36:38,227 --> 01:36:39,695 SET THE STAGE WITH THE KINDS OF 2707 01:36:39,695 --> 01:36:40,663 QUESTIONS WERE YOU ASKING ABOUT 2708 01:36:40,663 --> 01:36:41,597 ENSURING THAT WE'RE HITTING ALL 2709 01:36:41,597 --> 01:36:43,032 OF THE INSTITUTIONS, THAT WE'RE 2710 01:36:43,032 --> 01:36:45,001 HITTING ALL OF THE SCIENTIFIC 2711 01:36:45,001 --> 01:36:47,870 DISCIPLINES, AND REALLY COVERING 2712 01:36:47,870 --> 01:36:50,106 THE FULL TRANSLATIONAL SCIENCE 2713 01:36:50,106 --> 01:36:51,207 SPECTRUM, NOT JUST IN THE BASIC 2714 01:36:51,207 --> 01:36:52,208 SCIENCE AREA BUT ALL THE WAY 2715 01:36:52,208 --> 01:36:53,543 THROUGH TO IMPLEMENTATION 2716 01:36:53,543 --> 01:36:54,577 SCIENCE AND OTHER AREAS. 2717 01:36:54,577 --> 01:36:56,579 AND WHAT'S THE APPROPRIATE WAY 2718 01:36:56,579 --> 01:36:58,314 FOR DPCPSI TO TAKE A LEADERSHIP 2719 01:36:58,314 --> 01:36:59,615 ROLE IN THIS SPACE THAT WOULD 2720 01:36:59,615 --> 01:37:02,885 HAVE AN IMPACT ON NOT JUST 2721 01:37:02,885 --> 01:37:05,188 THINGS WITHIN OUR DIVISION BUT 2722 01:37:05,188 --> 01:37:08,257 WITHIN NIH AS A WHOLE. 2723 01:37:08,257 --> 01:37:09,759 SO WITH THOSE SLIDES SORT OF AS 2724 01:37:09,759 --> 01:37:10,860 BACKGROUND TO LET YOU KNOW WHAT 2725 01:37:10,860 --> 01:37:14,030 WE'RE THINKING IN THIS SPACE, WE 2726 01:37:14,030 --> 01:37:15,364 JUST WANTED TO OPEN IT FOR A 2727 01:37:15,364 --> 01:37:16,299 DISCUSSION A LITTLE BIT TO HEAR 2728 01:37:16,299 --> 01:37:19,335 FROM YOU ALL ABOUT WHETHER OR 2729 01:37:19,335 --> 01:37:22,004 NOT YOU'RE SUPPORTIVE OF OUR 2730 01:37:22,004 --> 01:37:23,172 PURSUING A WORKING GROUP IN THIS 2731 01:37:23,172 --> 01:37:24,607 AREA, AND ALSO IF THERE'S 2732 01:37:24,607 --> 01:37:25,575 QUESTIONS IN ADDITION TO THESE 2733 01:37:25,575 --> 01:37:29,412 SORT OF OPEN QUESTIONS WE'VE 2734 01:37:29,412 --> 01:37:31,380 OUTLINED HERE THAT YOU THINK 2735 01:37:31,380 --> 01:37:32,482 SUCH A WORKING GROUP SHOULD 2736 01:37:32,482 --> 01:37:33,249 PURSUE. 2737 01:37:33,249 --> 01:37:34,884 SO YOU CAN PULL THE SLIDES DOWN 2738 01:37:34,884 --> 01:37:37,053 AND I'M HAPPY TO TAKE FEEDBACK 2739 01:37:37,053 --> 01:37:38,454 AND DISCUSSION AND I SEE KEVIN 2740 01:37:38,454 --> 01:37:40,456 ALREADY HAS HIS HAND UP. 2741 01:37:40,456 --> 01:37:42,558 >> THANKS SO MUCH, CAROLYN. 2742 01:37:42,558 --> 01:37:44,727 YEP, LET'S OPEN IT UP FOR 2743 01:37:44,727 --> 01:37:47,463 QUESTIONS, COMMENTS, DISCUSSION. 2744 01:37:47,463 --> 01:37:49,899 KEVIN, PLEASE GO AHEAD. 2745 01:37:49,899 --> 01:37:52,502 >> HI, THANK YOU SO MUCH. 2746 01:37:52,502 --> 01:37:53,870 I WASN'T GOING TO SAY ANYTHING 2747 01:37:53,870 --> 01:37:56,339 OF COURSE BEFORE THIS, BUT I 2748 01:37:56,339 --> 01:38:00,810 HAVE BEEN THE BENEFICIARY OF ONE 2749 01:38:00,810 --> 01:38:02,011 DP1, SO I'M DOING WORK IN THE 2750 01:38:02,011 --> 01:38:06,149 SPACE OF AI AND PRIMARY CARE. 2751 01:38:06,149 --> 01:38:10,286 IF I WERE STAYING ON THE 2752 01:38:10,286 --> 01:38:11,587 COUNCIL, I WOULD DEFINITELY BE 2753 01:38:11,587 --> 01:38:13,789 WANTING TO BE PART OF THIS 2754 01:38:13,789 --> 01:38:15,558 WORKING GROUP SO I'M HAPPY -- 2755 01:38:15,558 --> 01:38:17,059 EVEN OFF THE COUNCIL IF PEOPLE 2756 01:38:17,059 --> 01:38:19,128 WANT TO CHAT, I'M HAPPY TO 2757 01:38:19,128 --> 01:38:19,428 PARTICIPATE. 2758 01:38:19,428 --> 01:38:21,631 >> I DID SAY THESE WORKING 2759 01:38:21,631 --> 01:38:22,832 GROUPS INCLUDE BOTH INTERNAL AND 2760 01:38:22,832 --> 01:38:23,866 EXTERNAL TO COUNCILMEMBERS. 2761 01:38:23,866 --> 01:38:25,001 >> OKAY. 2762 01:38:25,001 --> 01:38:26,302 WELL, THEN MAYBE I'LL DO IT. 2763 01:38:26,302 --> 01:38:31,474 BUT -- IN FACT, I WILL DO IT. 2764 01:38:31,474 --> 01:38:32,909 BUT I THINK IT'S A REALLY 2765 01:38:32,909 --> 01:38:33,609 TERRIFIC IDEA. 2766 01:38:33,609 --> 01:38:34,277 I THINK BOTH THE CONVERSATION 2767 01:38:34,277 --> 01:38:35,278 ABOUT METRICS BECAUSE THE WORLD 2768 01:38:35,278 --> 01:38:38,047 HAS CHANGED AND. SO METRICS YOU 2769 01:38:38,047 --> 01:38:39,282 MIGHT CHOOTION TO USE ARE VERY 2770 01:38:39,282 --> 01:38:39,549 DIFFERENT. 2771 01:38:39,549 --> 01:38:40,883 I ACTUALLY HAD THOUGHT AT ONE 2772 01:38:40,883 --> 01:38:43,252 POINT ABOUT A REALLY INTERESTING 2773 01:38:43,252 --> 01:38:46,088 HURDLE FOR PIONEER AWARDEES WHO 2774 01:38:46,088 --> 01:38:47,089 ARE ESPECIALLY MORE SENIOR 2775 01:38:47,089 --> 01:38:49,358 PEOPLE TO OVERCOME BEFORE 2776 01:38:49,358 --> 01:38:50,359 APPLYING, AND I'D LOVE TO CHAT 2777 01:38:50,359 --> 01:38:51,327 WITH THE WORKING GROUP ABOUT 2778 01:38:51,327 --> 01:38:53,829 THAT IDEA. 2779 01:38:53,829 --> 01:38:55,831 I THINK -- I WAS LOOKING -- I 2780 01:38:55,831 --> 01:38:57,200 WAS TRYING TO CAPTURE THAT 2781 01:38:57,200 --> 01:38:57,900 SLIDE, CAROLYN, THAT YOU HAD UP 2782 01:38:57,900 --> 01:38:59,068 THAT I JUST DIDN'T CAPTURE IN 2783 01:38:59,068 --> 01:39:02,572 TIME TO ANSWER THE EXACT 2784 01:39:02,572 --> 01:39:03,773 QUESTIONS, BUT I'M VERY 2785 01:39:03,773 --> 01:39:04,774 SUPPORTIVE AND THINK GETTING A 2786 01:39:04,774 --> 01:39:06,509 WORKING GROUP INVOLVED, 2787 01:39:06,509 --> 01:39:08,578 ESPECIALLY GIVEN -- AND I WON'T 2788 01:39:08,578 --> 01:39:10,479 CALL THEM AUSTERITY MEASURES, 2789 01:39:10,479 --> 01:39:12,381 BUT GIVEN WHAT'S HAPPENED 2790 01:39:12,381 --> 01:39:14,517 RECENTLY AT THE NIH, I THINK IT 2791 01:39:14,517 --> 01:39:15,985 WOULD BE VERY USEFUL FOR US TO 2792 01:39:15,985 --> 01:39:17,186 HAVE A CONVERSATION ABOUT WHAT 2793 01:39:17,186 --> 01:39:20,356 THIS PROGRAM CAN OFFER IN 2794 01:39:20,356 --> 01:39:23,192 ADDITION TO WHATEVER OVERARCHING 2795 01:39:23,192 --> 01:39:24,627 ECOSYSTEM IS FOR TRAINING AND 2796 01:39:24,627 --> 01:39:31,968 HIGH RISK HIGH REWARD WORK. 2797 01:39:31,968 --> 01:39:34,370 >> GREAT. 2798 01:39:34,370 --> 01:39:38,307 THANK YOU VERY MUCH, KEVIN. 2799 01:39:38,307 --> 01:39:40,610 NEXT I SEE RHONDA WITH HER HAND 2800 01:39:40,610 --> 01:39:40,943 RAISED. 2801 01:39:40,943 --> 01:39:41,611 PLEASE GO AHEAD. 2802 01:39:41,611 --> 01:39:44,213 >> THANK YOU. 2803 01:39:44,213 --> 01:39:47,049 I FIND THIS TO BE VERY 2804 01:39:47,049 --> 01:39:47,817 FASCINATING, BUT A QUESTION I 2805 01:39:47,817 --> 01:39:51,020 HAVE FOR YOU, I REALIZE THAT 2806 01:39:51,020 --> 01:39:54,624 MOST OF THE PARTICIPANTS ARE 2807 01:39:54,624 --> 01:39:56,359 FROM NIH VARIOUS DIVISIONS. 2808 01:39:56,359 --> 01:40:00,429 IS THERE ANY THOUGHT ABOUT 2809 01:40:00,429 --> 01:40:02,398 INCLUDING OTHERS WHO ARE MAJOR 2810 01:40:02,398 --> 01:40:04,333 STAKEHOLDERS IN HEALTHCARE IN 2811 01:40:04,333 --> 01:40:06,869 GENERAL IN THIS? 2812 01:40:06,869 --> 01:40:08,704 BECAUSE IT CAN BRING A DIFFERENT 2813 01:40:08,704 --> 01:40:09,972 PERSPECTIVE OR A DIFFERENT NEED. 2814 01:40:09,972 --> 01:40:14,877 SO LET ME GIVE AN EXAMPLE. 2815 01:40:14,877 --> 01:40:17,079 CERTAINLY THE CDC CITES CHRONIC 2816 01:40:17,079 --> 01:40:18,281 ILLNESSES, PARTICULARLY THOSE OF 2817 01:40:18,281 --> 01:40:19,582 HIGH PREVALENCE, THOSE THAT HAVE 2818 01:40:19,582 --> 01:40:23,452 A HIGH PROPENSITY FOR DEATH, BUT 2819 01:40:23,452 --> 01:40:24,887 ONE OF THE THINGS THEY ARE NOT 2820 01:40:24,887 --> 01:40:26,455 NECESSARILY LOOKING AT AT THIS 2821 01:40:26,455 --> 01:40:28,958 POINT AND PROBABLY ARE NOT AWARE 2822 01:40:28,958 --> 01:40:31,460 OF, ARE THOSE CONDITIONS THAT 2823 01:40:31,460 --> 01:40:33,896 ARE INCREASING IN TREND WHERE 2824 01:40:33,896 --> 01:40:37,033 THE ABILITY TO IDENTIFY THEM OR 2825 01:40:37,033 --> 01:40:41,203 TO TREAT THEM BECOMES KIND OF A 2826 01:40:41,203 --> 01:40:42,638 REAL GREAT TRIAL AND ERROR 2827 01:40:42,638 --> 01:40:44,640 PROCEDURE. 2828 01:40:44,640 --> 01:40:48,210 I SAY THAT TO SAY, BECAUSE TRIAL 2829 01:40:48,210 --> 01:40:49,845 AND ERROR WASTES TIME BUT IT 2830 01:40:49,845 --> 01:40:53,883 ALSO WASTES MONEY AS IT RELATES 2831 01:40:53,883 --> 01:40:55,985 TO ACCOMPLISHING WHAT NEEDS TO 2832 01:40:55,985 --> 01:40:57,953 BE ACCOMPLISHED. 2833 01:40:57,953 --> 01:40:59,388 AUTOIMMUNE DISEASE IS PROBABLY A 2834 01:40:59,388 --> 01:41:00,556 PRIME EXAMPLE OF THAT, WHICH HAS 2835 01:41:00,556 --> 01:41:01,324 INCREASED IN PREVALENCE AND 2836 01:41:01,324 --> 01:41:04,293 SEEMS TO HAVE QUITE A FEW 2837 01:41:04,293 --> 01:41:06,429 DIFFERENT CONDITIONS ATTACHED TO 2838 01:41:06,429 --> 01:41:06,662 THAT. 2839 01:41:06,662 --> 01:41:08,431 SO THAT IS ONE QUESTION. 2840 01:41:08,431 --> 01:41:11,267 SO I'M WONDERING WHETHER OR NOT 2841 01:41:11,267 --> 01:41:13,769 THERE WOULD BE SOME INPUT TO 2842 01:41:13,769 --> 01:41:15,204 THIS GROUP IN TERMS OF WHAT ARE 2843 01:41:15,204 --> 01:41:18,607 SOME OF THE REAL WORLD ISSUES 2844 01:41:18,607 --> 01:41:22,078 THAT ARE BEING DEALT WITH BY 2845 01:41:22,078 --> 01:41:27,016 THOSE WHO ARE TAKING ON THE 2846 01:41:27,016 --> 01:41:28,851 RESPONSIBILITY, THE POPULATIONS, 2847 01:41:28,851 --> 01:41:31,053 NOT ONLY FROM A HEALTH OUT COME 2848 01:41:31,053 --> 01:41:33,689 PERSPECTIVE BUT ALSO FROM WHAT I 2849 01:41:33,689 --> 01:41:36,192 WOULD CALL MONETARY 2850 01:41:36,192 --> 01:41:36,625 RESPONSIBILITIES. 2851 01:41:36,625 --> 01:41:38,828 SO FOR EXAMPLE, EMPLOYERS WHO 2852 01:41:38,828 --> 01:41:42,765 ARE SELF-FUNDED, HEALTH PLANS, 2853 01:41:42,765 --> 01:41:45,067 PROVIDER GROUPS THAT ARE NOW 2854 01:41:45,067 --> 01:41:47,570 TAKING ON ACCOUNTABLE -- BEING 2855 01:41:47,570 --> 01:41:49,438 ACCOUNTABLE FOR THE POPULATIONS 2856 01:41:49,438 --> 01:41:53,743 THAT THEY'RE SERVICING, SO 2857 01:41:53,743 --> 01:41:57,079 SOMEONE GETS ILL, THIS H THEY RY 2858 01:41:57,079 --> 01:41:58,848 HAVE TO HELP THAT POPULATION GET 2859 01:41:58,848 --> 01:41:59,915 BETTER IN A CERTAIN REGARD AND 2860 01:41:59,915 --> 01:42:01,984 THEY HAVE TO DO IT WITHIN A 2861 01:42:01,984 --> 01:42:03,085 CERTAIN WINDOW OF DOLLARS WHICH 2862 01:42:03,085 --> 01:42:07,022 I THINK WE ALL ARE REALIZING ARE 2863 01:42:07,022 --> 01:42:08,090 BECOMING LESS AND LESS. 2864 01:42:08,090 --> 01:42:09,425 SO IS THERE ANY THOUGHT ABOUT 2865 01:42:09,425 --> 01:42:12,461 EXTERNAL STAKEHOLDERS HAVING 2866 01:42:12,461 --> 01:42:13,796 SOME INPUT, NOT NECESSARILY ON 2867 01:42:13,796 --> 01:42:15,231 THE COUNCIL BUT HAVING SOME 2868 01:42:15,231 --> 01:42:16,198 INPUT AS BEING A VERY IMPORTANT 2869 01:42:16,198 --> 01:42:21,370 PART OF THE DISCUSSION? 2870 01:42:21,370 --> 01:42:23,005 >> YES, RHONDA, I SHOULD 2871 01:42:23,005 --> 01:42:24,640 CLARIFY, THE WORKING GROUP 2872 01:42:24,640 --> 01:42:25,841 MEMBERS THAT TRISH SHARED 2873 01:42:25,841 --> 01:42:26,809 PREVIOUSLY, THAT'S THE GROUP 2874 01:42:26,809 --> 01:42:32,615 WITHIN NIH WHO OVERSEES THE HRHR 2875 01:42:32,615 --> 01:42:33,382 PROGRAMS -- I SEEM TO BE 2876 01:42:33,382 --> 01:42:34,250 FREEZING A LITTLE BIT. 2877 01:42:34,250 --> 01:42:39,955 I WILL ALSO TURN MY CAMERA OFF. 2878 01:42:39,955 --> 01:42:42,458 SO THAT OVERSEES THE HRHR 2879 01:42:42,458 --> 01:42:43,893 PROGRAMS THAT WE ADMINISTER. 2880 01:42:43,893 --> 01:42:44,760 THAT'S SEPARATE FROM THE WORKING 2881 01:42:44,760 --> 01:42:45,928 GROUP WE'RE TALKING ABOUT RIGHT 2882 01:42:45,928 --> 01:42:47,696 NOW AND 100% THE WORKING GROUP 2883 01:42:47,696 --> 01:42:50,099 WE'RE PROPOSING RIGHT NOW WOULD 2884 01:42:50,099 --> 01:42:51,200 HAVE EXTERNAL PEOPLE AND AS 2885 01:42:51,200 --> 01:42:52,835 WE'VE BEEN DEVELOPING A 2886 01:42:52,835 --> 01:42:55,337 POTENTIAL ROSTER, WE'VE BEEN 2887 01:42:55,337 --> 01:42:56,806 CONSIDERING NOT JUST PEOPLE IN 2888 01:42:56,806 --> 01:42:58,507 SORT OF THE ACADEMIC AND 2889 01:42:58,507 --> 01:43:01,444 TRADITIONAL FUNDING EXPERTISE, 2890 01:43:01,444 --> 01:43:03,879 BUT ALSO ADDITIONAL BROADER 2891 01:43:03,879 --> 01:43:04,413 STAKEHOLDERS. 2892 01:43:04,413 --> 01:43:05,848 SO I HEAR YOU IN SORT OF MAKING 2893 01:43:05,848 --> 01:43:08,250 SURE WE'RE REPRESENTING THE 2894 01:43:08,250 --> 01:43:09,118 HEALTHCARE INNOVATION AND 2895 01:43:09,118 --> 01:43:09,752 CONSIDERATIONS ABOUT WHAT WE 2896 01:43:09,752 --> 01:43:11,086 NEED TO BE DOING IN HEALTHCARE 2897 01:43:11,086 --> 01:43:12,321 AS ONE OF THE KEY STAKEHOLDERS 2898 01:43:12,321 --> 01:43:13,389 THAT WE COULD BRING INTO THIS 2899 01:43:13,389 --> 01:43:13,956 WORKING GROUP. 2900 01:43:13,956 --> 01:43:15,991 AND THIS IS A GREAT OPPORTUNITY 2901 01:43:15,991 --> 01:43:17,793 ACTUALLY TO GET THAT TYPE OF 2902 01:43:17,793 --> 01:43:20,296 EXTERNAL FEEDBACK INTO THE NIH 2903 01:43:20,296 --> 01:43:20,629 PROCESS. 2904 01:43:20,629 --> 01:43:21,397 THAT'S PART OF THE REASON TO 2905 01:43:21,397 --> 01:43:26,669 HAVE A GROUP LIKE THIS. 2906 01:43:26,669 --> 01:43:29,638 >> THANK YOU. 2907 01:43:29,638 --> 01:43:31,240 >> THANK YOU FOR THAT EXCELLENT 2908 01:43:31,240 --> 01:43:31,674 FEEDBACK. 2909 01:43:31,674 --> 01:43:35,845 JEAN, I SEE YOU AS THE NEXT 2910 01:43:35,845 --> 01:43:36,078 PERSON. 2911 01:43:36,078 --> 01:43:37,813 >> I DO SUPPORT WHAT RHONDA JUST 2912 01:43:37,813 --> 01:43:38,113 SAID. 2913 01:43:38,113 --> 01:43:38,948 I THINK THAT'S REALLY 2914 01:43:38,948 --> 01:43:39,248 INTERESTING. 2915 01:43:39,248 --> 01:43:40,950 I WAS REALLY ALSO THINKING ABOUT 2916 01:43:40,950 --> 01:43:41,283 STAKEHOLDERS. 2917 01:43:41,283 --> 01:43:44,353 BUT TO GO BACK TO AS WE DECIDE 2918 01:43:44,353 --> 01:43:46,055 ON WHAT THAT, WOULDING GROUP 2919 01:43:46,055 --> 01:43:48,190 SHOULD LOOK LIKE, WHEN I THINK 2920 01:43:48,190 --> 01:43:50,125 ABOUT HOW WE DECIDE WHAT'S A 2921 01:43:50,125 --> 01:43:52,328 CRITICAL TOPIC, I FEEL THAT'S 2922 01:43:52,328 --> 01:43:53,863 GOING TO BE PROBABLY THE MOST 2923 01:43:53,863 --> 01:43:55,264 IMPORTANT THING AS WE SET UP THE 2924 01:43:55,264 --> 01:43:55,931 WORKING GROUPS. 2925 01:43:55,931 --> 01:43:57,933 HOW DO WE DEFINE A CRITICAL 2926 01:43:57,933 --> 01:43:59,301 TOPIC, A CRITICAL TOPIC FOR YOU 2927 01:43:59,301 --> 01:44:01,504 MAY BE DIFFERENT FROM ME. 2928 01:44:01,504 --> 01:44:03,639 I THINK ABOUT IS IT THE IMPACT 2929 01:44:03,639 --> 01:44:04,740 IT HAS, LIKE RARE DISEASES MAY 2930 01:44:04,740 --> 01:44:05,841 NOT HAVE THE SAME IMPACT IN 2931 01:44:05,841 --> 01:44:12,281 TERMS OF NUMBERS, BUT VEL VERY 2932 01:44:12,281 --> 01:44:12,882 OBVIOUSLY CRITICAL FOR PEOPLE 2933 01:44:12,882 --> 01:44:14,817 WHO HAVE THOSE RARE DISEASES. 2934 01:44:14,817 --> 01:44:18,854 IT'S PROBABLY AN OUTSIDE OF THE 2935 01:44:18,854 --> 01:44:20,055 BOX CONVERSATION BUT HOW DO WE 2936 01:44:20,055 --> 01:44:21,056 DEFINE THAT, WHAT ARE THE 2937 01:44:21,056 --> 01:44:22,358 METRICS WE'RE GOING TO USE AND 2938 01:44:22,358 --> 01:44:23,659 HOPING THAT, WOULDING GROUP SORT 2939 01:44:23,659 --> 01:44:24,760 OF APPROACHES IT THAT WAY. 2940 01:44:24,760 --> 01:44:26,629 WHEN I THINK ABOUT 2941 01:44:26,629 --> 01:44:31,166 INTERDISCIPLINARY AND BEING AT 2942 01:44:31,166 --> 01:44:32,101 THE CRASS SECTION OF DIFFERENT 2943 01:44:32,101 --> 01:44:33,736 THINGS, IN THAT SPACE I THINK 2944 01:44:33,736 --> 01:44:35,170 ABOUT COLLABORATIONS, BRINGING 2945 01:44:35,170 --> 01:44:36,038 TOGETHER DIFFERENT GROUPS, WHAT 2946 01:44:36,038 --> 01:44:37,806 DO WE DEFINE AS A COLLABORATION 2947 01:44:37,806 --> 01:44:39,875 THAT COULD WORK, WHAT DOES THAT 2948 01:44:39,875 --> 01:44:41,544 LOOK LIKE, WHAT ARE WE TRYING TO 2949 01:44:41,544 --> 01:44:41,744 FIND. 2950 01:44:41,744 --> 01:44:43,279 IN THERE, I THINK ABOUT 2951 01:44:43,279 --> 01:44:46,115 STAKEHOLDERS LIKE INDUSTRY 2952 01:44:46,115 --> 01:44:46,549 PARTNERSHIPS. 2953 01:44:46,549 --> 01:44:48,517 SO I DON'T THINK IT NECESSARILY 2954 01:44:48,517 --> 01:44:49,718 IS ACADEMIC TO ACADEMIC. 2955 01:44:49,718 --> 01:44:51,587 IT MIGHT BE INTERESTING TO HAVE 2956 01:44:51,587 --> 01:44:52,621 ACADEMIC WITH INDUSTRY WHERE WE 2957 01:44:52,621 --> 01:44:53,889 HAVE IDENTIFIED SOMETHING THAT 2958 01:44:53,889 --> 01:44:57,927 IS OF CRITICAL IMPORTANCE, 2959 01:44:57,927 --> 01:44:59,528 BECAUSE TO ME WHEN WE DO THE 2960 01:44:59,528 --> 01:45:01,263 HIGH RISK REWARD KIND OF AREAS, 2961 01:45:01,263 --> 01:45:01,997 SOMETIMES THERE'S NO 2962 01:45:01,997 --> 01:45:02,665 SUSTAINABILITY IN THEM. 2963 01:45:02,665 --> 01:45:04,199 SO WE DO THEM, THEY GET THE 2964 01:45:04,199 --> 01:45:05,200 GRANT, THEY DO WHATEVER IT IS 2965 01:45:05,200 --> 01:45:06,535 THEY'RE GOING TO DO, AND WE 2966 01:45:06,535 --> 01:45:09,371 DON'T HAVE RESOURCES TO FOLLOW 2967 01:45:09,371 --> 01:45:10,139 UP. 2968 01:45:10,139 --> 01:45:11,807 SO HIGH RISK, HIGH REWARD IS 2969 01:45:11,807 --> 01:45:13,108 FABULOUS, BUT THEN YOU HAVE TO 2970 01:45:13,108 --> 01:45:15,411 GO FROM REWARD TO ACTUALLY 2971 01:45:15,411 --> 01:45:17,613 IMPLEMENTATION, AND THAT IS 2972 01:45:17,613 --> 01:45:18,581 DIFFERENT, HOW ARE WE GOING TO 2973 01:45:18,581 --> 01:45:19,782 LOOK AT THAT AND HOW ARE WE 2974 01:45:19,782 --> 01:45:20,849 GOING TO PROPOSE TO GET FROM 2975 01:45:20,849 --> 01:45:24,153 POINT A TO POINT B. 2976 01:45:24,153 --> 01:45:25,588 SO BROADENING PARTICIPATION IS 2977 01:45:25,588 --> 01:45:27,990 THE LAST THING I WANT TO TALK 2978 01:45:27,990 --> 01:45:28,624 ABOUT. 2979 01:45:28,624 --> 01:45:31,594 IT'S PEOPLE FROM DIFFERENT WALKS 2980 01:45:31,594 --> 01:45:33,996 OF LIFE, DIFFERENT PLACES, 2981 01:45:33,996 --> 01:45:34,763 DIFFERENT DIVERSITY PORTFOLIO, 2982 01:45:34,763 --> 01:45:38,801 AND I REALLY WANT US TO BE VERY 2983 01:45:38,801 --> 01:45:42,204 THOUGHTFUL AND DELIBERATE AND 2984 01:45:42,204 --> 01:45:46,575 DILIGENT ABOUT WHAT WE MEAN BY 2985 01:45:46,575 --> 01:45:49,345 BROADENING PARTICIPATION SMS. 2986 01:45:49,345 --> 01:45:50,646 SO THOSE ARE MY 2 CENTS. 2987 01:45:50,646 --> 01:45:51,447 >> EXCELLENT FEEDBACK. 2988 01:45:51,447 --> 01:45:53,649 AGAIN YOU GUYS ARE JUST ALL 2989 01:45:53,649 --> 01:45:55,284 HIGHLIGHTING FOR ME THROUGH YOUR 2990 01:45:55,284 --> 01:45:57,720 DISCUSSION MORE ENTHUSIASM AND 2991 01:45:57,720 --> 01:45:58,821 THE KEY CHALLENGES AND THOUGHTS 2992 01:45:58,821 --> 01:46:00,155 THAT WHICH SHOULD BE BRINGING 2993 01:46:00,155 --> 01:46:01,991 FORWARD AND GIVING GOOD 2994 01:46:01,991 --> 01:46:02,791 CONSIDERATION. 2995 01:46:02,791 --> 01:46:03,959 >> EXACTLY. 2996 01:46:03,959 --> 01:46:04,259 OKAY. 2997 01:46:04,259 --> 01:46:07,229 GREAT. 2998 01:46:07,229 --> 01:46:08,998 I THINK THE LAST PERSON WHO HAD 2999 01:46:08,998 --> 01:46:09,898 THEIR HAND RAISED FOR COMMENT IS 3000 01:46:09,898 --> 01:46:10,232 KENT. 3001 01:46:10,232 --> 01:46:11,300 KENT, WOULD YOU LIKE TO GO 3002 01:46:11,300 --> 01:46:12,768 AHEAD? 3003 01:46:12,768 --> 01:46:18,307 >> THANKS. 3004 01:46:18,307 --> 01:46:20,175 CAROLYN, UC DAVIS, GOOD TO SEE 3005 01:46:20,175 --> 01:46:21,043 YOU AGAIN. 3006 01:46:21,043 --> 01:46:23,112 >> GOOD TO SEE YOU, KENT. 3007 01:46:23,112 --> 01:46:25,347 >> JUST CLARIFICATION ON THE 3008 01:46:25,347 --> 01:46:26,315 BOUNDARIES OF WHAT THE WORKING 3009 01:46:26,315 --> 01:46:30,886 GROUP IS TO WORK WITHIN. 3010 01:46:30,886 --> 01:46:33,889 SO IS IT PRIMARILY A REVIEW OF 3011 01:46:33,889 --> 01:46:38,127 HOW THE HRHR PROGRAMS ARE NOW, 3012 01:46:38,127 --> 01:46:40,195 AND MAYBE HAD TO MODIFY AND 3013 01:46:40,195 --> 01:46:41,563 TWEAK THEM TO BE MORE 3014 01:46:41,563 --> 01:46:42,665 TRANSFORMATIVE, OR IS IT LOOKING 3015 01:46:42,665 --> 01:46:46,235 AT A WHOLESALE RESTRUCTURING AND 3016 01:46:46,235 --> 01:46:47,803 MAYBE THROWING OUT THE OLD AND 3017 01:46:47,803 --> 01:46:49,438 BUILDING SOMETHING NEW? 3018 01:46:49,438 --> 01:46:50,539 WHAT'S THE BOUNDARIES THAT 3019 01:46:50,539 --> 01:46:53,609 YOU'RE GOING TO WANT THE WORKING 3020 01:46:53,609 --> 01:46:55,911 GROUP TO OPERATE WITHIN? 3021 01:46:55,911 --> 01:46:56,545 >> RIGHT. 3022 01:46:56,545 --> 01:46:58,047 I DON'T NEED TO BE AN EVALUATION 3023 01:46:58,047 --> 01:47:00,315 OF THE EXISTING HRHR PROGRAMS AS 3024 01:47:00,315 --> 01:47:01,583 TRISH AND BECKY HIGHLIGHTED, WE 3025 01:47:01,583 --> 01:47:05,621 ALREADY DO THAT AS PART OF OUR 3026 01:47:05,621 --> 01:47:08,524 NORMAL EVALUATION WITHIN THE 3027 01:47:08,524 --> 01:47:09,124 COMMON FUND. 3028 01:47:09,124 --> 01:47:13,295 REALLY THE GOAL IS TO THINK 3029 01:47:13,295 --> 01:47:14,830 ABOUT TRANSFORMATIVE RESEARCH AT 3030 01:47:14,830 --> 01:47:17,466 NIH, NOT JUST FUNDED THROUGH OSC 3031 01:47:17,466 --> 01:47:19,868 AND DPCPSI BUT NIH BROADLY, AND 3032 01:47:19,868 --> 01:47:24,573 MAKE SURE AND THINK ABOUT WHAT 3033 01:47:24,573 --> 01:47:26,542 ELSE CAN NIH BE DOING, WHAT'S A 3034 01:47:26,542 --> 01:47:28,510 FORWARD LOOK AT THINGS THAT NIH 3035 01:47:28,510 --> 01:47:31,447 CAN AND SHOULD BE DOING IN THIS 3036 01:47:31,447 --> 01:47:33,949 SPACE, HOPEFULLY COMPLEMENTING 3037 01:47:33,949 --> 01:47:34,616 RATHER THAN REPLACING OUR 3038 01:47:34,616 --> 01:47:38,887 EXISTING HRHR EFFORTS. 3039 01:47:38,887 --> 01:47:40,222 BUT OBVIOUSLY THERE MAY BE SOME 3040 01:47:40,222 --> 01:47:42,157 IMPACT ON OUR EXISTING HRHR 3041 01:47:42,157 --> 01:47:43,258 EFFORTS BUT IT'S REALLY MUCH 3042 01:47:43,258 --> 01:47:44,693 MORE OF A FORWARD LOOKING WHAT 3043 01:47:44,693 --> 01:47:47,296 MORE SHOULD WE BE DOING RATHER 3044 01:47:47,296 --> 01:47:49,064 THAN A DIRECT EVALUATION OF THE 3045 01:47:49,064 --> 01:47:50,032 EXISTING PROGRAMS. 3046 01:47:50,032 --> 01:47:54,536 DOES THAT MAKE SENSE? 3047 01:47:54,536 --> 01:47:55,604 >> YES, OKAY. 3048 01:47:55,604 --> 01:47:56,705 THANK YOU VERY MUCH. 3049 01:47:56,705 --> 01:47:57,506 >> THANKS. 3050 01:47:57,506 --> 01:48:00,142 AND I THINK JUST TO SORT OF 3051 01:48:00,142 --> 01:48:01,677 RECAP SOME OF THE FEEDBACK THAT 3052 01:48:01,677 --> 01:48:03,312 WE GOT HIGHLIGHTING SORT OF THE 3053 01:48:03,312 --> 01:48:07,349 NEED TO INCLUDE EXTERNAL 3054 01:48:07,349 --> 01:48:08,217 INDIVIDUALS FROM HEALTHCARE AND 3055 01:48:08,217 --> 01:48:10,519 OTHER INDUSTRIES WILL REALLY 3056 01:48:10,519 --> 01:48:12,421 PROVIDE US WITH THAT RANGE OF 3057 01:48:12,421 --> 01:48:13,655 SCIENTIFIC EXPERTISE TO ENSURE 3058 01:48:13,655 --> 01:48:15,290 THAT WE ARE MEETING THE GOALS 3059 01:48:15,290 --> 01:48:17,226 THAT CAROLYN JUST LAID OUT IN 3060 01:48:17,226 --> 01:48:18,694 TERMS OF REALLY PUSHING THE 3061 01:48:18,694 --> 01:48:19,895 BOUNDARIES AND BEING 3062 01:48:19,895 --> 01:48:21,530 TRANSFORMATIVE IN OUR HR 3063 01:48:21,530 --> 01:48:23,832 PORTFOLIO. 3064 01:48:23,832 --> 01:48:25,134 OKAY. 3065 01:48:25,134 --> 01:48:27,803 I THINK THAT THAT BRINGS OUR 3066 01:48:27,803 --> 01:48:29,438 MORNING SESSION TO A CLOSE. 3067 01:48:29,438 --> 01:48:31,306 OUR OPEN SESSION TO A CLOSE. 3068 01:48:31,306 --> 01:48:33,976 WE'RE DOING VERY WELL ON TIME. 3069 01:48:33,976 --> 01:48:35,711 WE'RE 10 MINUTES AHEAD OF 3070 01:48:35,711 --> 01:48:37,679 SCHEDULE, SO WE GET A SLIGHTLY 3071 01:48:37,679 --> 01:48:38,247 LONGER BREAK. 3072 01:48:38,247 --> 01:48:39,815 SO WE'RE GOING TO TAKE A SHORT 3073 01:48:39,815 --> 01:48:41,650 BREAK BEFORE WE TRANSITION TO 3074 01:48:41,650 --> 01:48:43,619 THE CLOSED SESSION OF TODAY'S 3075 01:48:43,619 --> 01:48:43,852 MEETING. 3076 01:48:43,852 --> 01:48:45,954 SO I'M GOING TO ASK ALL OF OUR 3077 01:48:45,954 --> 01:48:47,456 COUNCILMEMBERS TO REMAIN LOGGED 3078 01:48:47,456 --> 01:48:48,824 IN AND MUTED. 3079 01:48:48,824 --> 01:48:53,595 WE WILL SEE EVERYONE BACK AT 3080 01:48:53,595 --> 01:48:53,862 12:15 P.M. 3081 01:48:53,862 --> 01:48:55,397 ONLY COUNCILMEMBERS AND NIH 3082 01:48:55,397 --> 01:48:56,732 STAFF WITH THE NEED TO KNOW WILL 3083 01:48:56,732 --> 01:48:58,834 BE PARTICIPATING IN THE CLOSED 3084 01:48:58,834 --> 01:48:59,268 SESSION. 3085 01:48:59,268 --> 01:49:00,569 FOR EVERYONE ELSE, THE OPEN 3086 01:49:00,569 --> 01:49:04,039 SESSION WILL RESUME AT 1:15 P.M. 3087 01:49:04,039 --> 01:49:04,571 THANK YOU ALL. 3088 01:49:05,923 --> 01:49:08,893 >> OKAY, WELCOME BACK, EVERYONE. 3089 01:49:08,893 --> 01:49:11,729 WE ARE RESUMING OPEN SESSION. 3090 01:49:11,729 --> 01:49:13,698 NOW IT IS MY GREAT HONOR AND 3091 01:49:13,698 --> 01:49:16,134 PRIVILEGE TO INTRODUCE OUR NEXT 3092 01:49:16,134 --> 01:49:18,302 SPEAKER, DR. JAY BHATTACHARYA, 3093 01:49:18,302 --> 01:49:20,772 THE 18TH DIRECTOR OF THE 3094 01:49:20,772 --> 01:49:22,907 NATIONAL INSTITUTES OF HEALTH. 3095 01:49:22,907 --> 01:49:24,142 PRESIDENT TRUMP NOMINATED HIM 3096 01:49:24,142 --> 01:49:26,611 FOR THE POSITION ON 3097 01:49:26,611 --> 01:49:27,812 NOVEMBER 26TH, 2024, AND THE 3098 01:49:27,812 --> 01:49:30,982 U.S. SENATE CONFIRMED HIM ON 3099 01:49:30,982 --> 01:49:32,517 MARCH 25TH, 2025. 3100 01:49:32,517 --> 01:49:34,819 AS DIRECTOR, DR. BHATTACHARYA IS 3101 01:49:34,819 --> 01:49:37,021 OVERSEEING THE NATION'S PREMIER 3102 01:49:37,021 --> 01:49:39,957 MEDICAL RESEARCH AGENCY. 3103 01:49:39,957 --> 01:49:41,359 DR. BHATTACHARYA WILL PLAY AN 3104 01:49:41,359 --> 01:49:43,127 INSTRUMENTAL ROLE IN SHAPING THE 3105 01:49:43,127 --> 01:49:44,762 AGENCY'S ACTIVITIES AND OUTLOOK 3106 01:49:44,762 --> 01:49:47,932 AND ENSURING THEY ALIGN WITH THE 3107 01:49:47,932 --> 01:49:48,566 PRESIDENT'S MAKE AMERICA HEALTHY 3108 01:49:48,566 --> 01:49:49,600 AGAIN COMMISSION. 3109 01:49:49,600 --> 01:49:52,003 A RENOWNED DOCTOR, RESEARCHER 3110 01:49:52,003 --> 01:49:54,071 AND HEALTH ECONOMIST, 3111 01:49:54,071 --> 01:49:55,706 DR. BHATTACHARYA HELD A TENURED 3112 01:49:55,706 --> 01:49:56,841 PROFESSORSHIP IN THE MEDICAL 3113 01:49:56,841 --> 01:49:58,442 SCHOOL AT STANFORD UNIVERSITY IN 3114 01:49:58,442 --> 01:50:01,279 CALIFORNIA. 3115 01:50:01,279 --> 01:50:02,280 DR. BHATTACHARYA'S RESEARCH HAS 3116 01:50:02,280 --> 01:50:05,349 FOCUSED ON POPULATION AGING AND 3117 01:50:05,349 --> 01:50:07,418 CHRONIC DISEASE, PARTICULARLY ON 3118 01:50:07,418 --> 01:50:08,719 THE HEALTH AND WELL-BEING OF 3119 01:50:08,719 --> 01:50:11,455 VULNERABLE POPULATIONS. 3120 01:50:11,455 --> 01:50:12,456 ENCOURAGING DIFFERENT 3121 01:50:12,456 --> 01:50:14,425 PERSPECTIVES WILL BE CENTRAL TO 3122 01:50:14,425 --> 01:50:15,827 DR. BHATTACHARYA'S APPROACH TO 3123 01:50:15,827 --> 01:50:17,461 LEADING NIH AS PART OF HIS 3124 01:50:17,461 --> 01:50:19,096 LARGER MISSION TO RESTORE PUBLIC 3125 01:50:19,096 --> 01:50:21,432 TRUST IN SCIENCE. 3126 01:50:21,432 --> 01:50:22,733 ALONGSIDE SECRETARY KENNEDY, HE 3127 01:50:22,733 --> 01:50:24,368 WILL CHAMPION INNOVATIVE, 3128 01:50:24,368 --> 01:50:26,571 CUTTING EDGE RESEARCH THAT FUELS 3129 01:50:26,571 --> 01:50:28,639 NEAR-TERM SOLUTIONS FOR PATIENTS 3130 01:50:28,639 --> 01:50:30,208 WHILE █BALANCING INVESTMENTS IN 3131 01:50:30,208 --> 01:50:32,143 BASIC SCIENCE. 3132 01:50:32,143 --> 01:50:33,678 DR. BHATTACHARYA EARNED HIS 3133 01:50:33,678 --> 01:50:35,646 BACHELOR'S AND MASTER'S DEGREES 3134 01:50:35,646 --> 01:50:37,315 IN ECONOMICS FROM STANFORD 3135 01:50:37,315 --> 01:50:37,949 UNIVERSITY. 3136 01:50:37,949 --> 01:50:39,750 HE THEN COMPLETED MEDICAL SCHOOL 3137 01:50:39,750 --> 01:50:42,119 AND EARNED A PH.D. IN ECONOMICS 3138 01:50:42,119 --> 01:50:45,056 ALSO FROM STANFORD UNIVERSITY. 3139 01:50:45,056 --> 01:50:45,723 DR. BHATTACHARYA, THE FLOOR IS 3140 01:50:45,723 --> 01:50:49,126 YOURS. 3141 01:50:49,126 --> 01:50:59,203 >> 3142 01:51:01,272 --> 01:51:02,373 >> WE CAN'T HEAR. 3143 01:51:02,373 --> 01:51:03,741 >> CAN YOU HEAR ME NOW? 3144 01:51:03,741 --> 01:51:05,109 >> YES, WE CAN. 3145 01:51:05,109 --> 01:51:10,548 >> OKAY. 3146 01:51:10,548 --> 01:51:11,415 I'M ABSOLUTELY DELIGHTED I'VE 3147 01:51:11,415 --> 01:51:14,252 HAD THE CHANCE TO LEAD THE NIH 3148 01:51:14,252 --> 01:51:24,495 AT THIS TIME. 3149 01:51:25,696 --> 01:51:27,198 SO FOR THIS TALK, WHAT I THOUGHT 3150 01:51:27,198 --> 01:51:28,499 I'D DO IS I WOULD TALK A LITTLE 3151 01:51:28,499 --> 01:51:29,800 BIT ABOUT MY BACKGROUND. 3152 01:51:29,800 --> 01:51:30,768 NICOLE MENTIONED SOME OF IT BUT 3153 01:51:30,768 --> 01:51:32,837 I JUST WANTED TO EMPHASIZE A 3154 01:51:32,837 --> 01:51:35,673 COUPLE POINTS ABOUT IT, IN 3155 01:51:35,673 --> 01:51:37,108 PARTICULAR MY LOVE FOR THE NIH 3156 01:51:37,108 --> 01:51:39,277 AND FOR THE MISSION OF THE NIH, 3157 01:51:39,277 --> 01:51:40,278 AND MY ABSOLUTE COMMITMENT TO 3158 01:51:40,278 --> 01:51:42,113 MAKE SURE THAT THE NIH CONTINUES 3159 01:51:42,113 --> 01:51:45,516 TO BE THE CROWN JEWEL OF 3160 01:51:45,516 --> 01:51:46,584 RESEARCH, BIOMEDICAL RESEARCH IN 3161 01:51:46,584 --> 01:51:47,818 THE WHOLE WORLD. 3162 01:51:47,818 --> 01:51:49,787 I'LL TALK A LITTLE ABOUT THE 3163 01:51:49,787 --> 01:51:51,322 LEADERSHIP TRANSITION AND OTHER 3164 01:51:51,322 --> 01:51:53,291 CHANGES, AND IN PARTICULAR I'LL 3165 01:51:53,291 --> 01:51:55,159 FOCUS ON SOME OF THE EARLY 3166 01:51:55,159 --> 01:51:57,662 INITIATIVES THAT I'VE WORKED ON 3167 01:51:57,662 --> 01:52:00,498 THAT I HOPE WE CAN GET -- THAT 3168 01:52:00,498 --> 01:52:02,600 WILL MAKE THE RESEARCH COMMUNITY 3169 01:52:02,600 --> 01:52:04,869 HAVE AVAILABILITY TO DATA AND 3170 01:52:04,869 --> 01:52:06,404 OTHER ACCESS TO RESEARCH 3171 01:52:06,404 --> 01:52:08,272 RESOURCES THAT THEY DIDN'T 3172 01:52:08,272 --> 01:52:09,273 PREVIOUSLY HAVE ACCESS TO, AS 3173 01:52:09,273 --> 01:52:12,209 WELL AS AN INITIATIVE ON THE 3174 01:52:12,209 --> 01:52:15,947 ETIOLOGY OF ALZHEIMER'S AND ITS 3175 01:52:15,947 --> 01:52:17,114 VARIOUS MANIFESTATIONS. 3176 01:52:17,114 --> 01:52:18,316 FINALLY, I'LL END WITH MY VISION 3177 01:52:18,316 --> 01:52:26,424 FOR THE NIH. 3178 01:52:26,424 --> 01:52:28,626 SO NICOLE MENTIONED THAT I CAME 3179 01:52:28,626 --> 01:52:30,461 FROM STANFORD. 3180 01:52:30,461 --> 01:52:33,097 I IN FACT WAS AT STANFORD FOR 3181 01:52:33,097 --> 01:52:36,801 ALMOST 39 YEARS, SO MY ENTIRE 3182 01:52:36,801 --> 01:52:40,204 OUTLOOK IS ROOTED IN THE 3183 01:52:40,204 --> 01:52:41,305 BIOMEDICAL COMMUNITY WHERE 3184 01:52:41,305 --> 01:52:42,406 STANFORD HAS PLAYED SUCH AN 3185 01:52:42,406 --> 01:52:43,074 IMPORTANT ROLE. 3186 01:52:43,074 --> 01:52:44,241 BUT I SHOULD ALSO MENTION THAT 3187 01:52:44,241 --> 01:52:45,776 THE NIH HAS PLAYED A 3188 01:52:45,776 --> 01:52:47,745 TREMENDOUSLY IMPORTANT ROLE IN 3189 01:52:47,745 --> 01:52:50,081 MY OWN DEVELOPMENT. 3190 01:52:50,081 --> 01:52:51,816 I'VE BEEN A NIH-FUNDED 3191 01:52:51,816 --> 01:52:53,985 RESEARCHER MY ENTIRE CAREER. 3192 01:52:53,985 --> 01:52:56,520 I'VE SERVED ON NIH STUDY 3193 01:52:56,520 --> 01:52:56,954 SECTIONS. 3194 01:52:56,954 --> 01:52:59,023 I'VE WORKED VERY CLOSELY WITH 3195 01:52:59,023 --> 01:53:01,425 NIH OFFICIALS IN MANY, MANY 3196 01:53:01,425 --> 01:53:02,860 DIFFERENT PROJECTS BEFORE I 3197 01:53:02,860 --> 01:53:04,595 BECAME THE NIH DIRECTOR. 3198 01:53:04,595 --> 01:53:06,564 AND I LOVE THE NIH. 3199 01:53:06,564 --> 01:53:09,400 IT'S TO ME AN INSTITUTION THAT I 3200 01:53:09,400 --> 01:53:11,969 AM ABSOLUTELY COMMITTED TO 3201 01:53:11,969 --> 01:53:12,503 MAKING SERVE THE AMERICAN 3202 01:53:12,503 --> 01:53:12,903 PEOPLE. 3203 01:53:12,903 --> 01:53:15,639 THE MISSION OF THE NIH IS 3204 01:53:15,639 --> 01:53:17,408 ABSOLUTELY THE CORE OF MY 3205 01:53:17,408 --> 01:53:19,276 RESEARCH AGENDA AS WELL, 3206 01:53:19,276 --> 01:53:21,445 RESEARCH AIMED AT IMPROVING THE 3207 01:53:21,445 --> 01:53:23,047 HEALTH, LONGEVITY AND WELL-BEING 3208 01:53:23,047 --> 01:53:25,483 OF THE AMERICAN PEOPLE. 3209 01:53:25,483 --> 01:53:26,584 THAT IS A MISSION I THINK THAT 3210 01:53:26,584 --> 01:53:28,352 WE ALL CAN AGREE ON. 3211 01:53:28,352 --> 01:53:31,288 AND IT'S THAT MISSION I WANT TO 3212 01:53:31,288 --> 01:53:32,423 MAKE BETTER WHILE I'M THE 3213 01:53:32,423 --> 01:53:38,295 DIRECTOR OF THE NIH. 3214 01:53:38,295 --> 01:53:40,031 SO FIRST SOME LEADERSHIP 3215 01:53:40,031 --> 01:53:40,598 TRANSITIONS. 3216 01:53:40,598 --> 01:53:45,836 I SHOULD MENTION FIRST, NICOLE, 3217 01:53:45,836 --> 01:53:53,344 ANY CONTROL KLEINKLEINSTREUER IS 3218 01:53:53,344 --> 01:53:55,346 THE HEAD OF DPCPSI. 3219 01:53:55,346 --> 01:53:56,714 SHE WAS PREVIOUSLY THE DIRECTOR 3220 01:53:56,714 --> 01:53:58,416 OF THE NATIONAL TOXICOLOGY 3221 01:53:58,416 --> 01:53:59,383 PROGRAM, INTERAGENCY CENTER FOR 3222 01:53:59,383 --> 01:54:01,585 THE EVALUATION OF ALTERNATIVE 3223 01:54:01,585 --> 01:54:04,221 AND TOXICOLOGICAL METHODS. 3224 01:54:04,221 --> 01:54:05,623 THERE ARE MANY LEADERSHIP 3225 01:54:05,623 --> 01:54:07,158 TRANSITIONS HAPPENING, AND IN 3226 01:54:07,158 --> 01:54:08,059 PARTICULAR, THE LEADERSHIP OF 3227 01:54:08,059 --> 01:54:12,096 THE INSTITUTES, I'M COMMITTED TO 3228 01:54:12,096 --> 01:54:14,065 A NORMAL PROCESS TO REPLACE THE 3229 01:54:14,065 --> 01:54:16,767 PEOPLE THAT HAVE LEFT AND 3230 01:54:16,767 --> 01:54:17,768 RETIRED. 3231 01:54:17,768 --> 01:54:21,372 THIS TIME OF TRANSITION IS, I 3232 01:54:21,372 --> 01:54:22,907 RECOGNIZE AND HAVE HEARD FROM SO 3233 01:54:22,907 --> 01:54:24,542 MANY OF MY COLLEAGUES AND 3234 01:54:24,542 --> 01:54:25,743 FRIENDS A TIME OF ANXIETY AND 3235 01:54:25,743 --> 01:54:26,977 CHANGE, BUT I WANT TO MAKE SURE 3236 01:54:26,977 --> 01:54:29,246 THAT EVERYONE UNDERSTANDS THAT 3237 01:54:29,246 --> 01:54:30,347 ALTHOUGH EVERY INCH OF THE 3238 01:54:30,347 --> 01:54:31,982 FEDERAL GOVERNMENT IS UNDER 3239 01:54:31,982 --> 01:54:32,750 SCRUTINY AND OF COURSE THE NIH 3240 01:54:32,750 --> 01:54:34,285 IS NOT EXEMPT, THE MISSION OF 3241 01:54:34,285 --> 01:54:35,719 THE NIH WILL CONTINUE. 3242 01:54:35,719 --> 01:54:37,555 AS WE NAVIGATE THESE CHALLENGES, 3243 01:54:37,555 --> 01:54:38,889 I WILL DO MY BEST TO LEAD THE 3244 01:54:38,889 --> 01:54:41,325 NIH WITH THE FORUMS AND 3245 01:54:41,325 --> 01:54:42,393 IMPLEMENT NEW POLICIES THAT 3246 01:54:42,393 --> 01:54:43,394 ENDEAVOR TO EARN YOUR TRUST AND 3247 01:54:43,394 --> 01:54:44,595 THE TRUST OF THE SCIENTIFIC 3248 01:54:44,595 --> 01:54:45,563 COMMUNITY. 3249 01:54:45,563 --> 01:54:46,864 AT THE END OF THIS, THE NIH WILL 3250 01:54:46,864 --> 01:54:51,035 BE A STRONGER INSTITUTION THAT 3251 01:54:51,035 --> 01:54:54,972 FOSTERS SCIENTIFIC DISCUSSION, 3252 01:54:54,972 --> 01:54:56,373 DEBATE AND ADVANCES IN NEW 3253 01:54:56,373 --> 01:54:58,943 TECHNOLOGIES, NEW WAYS OF 3254 01:54:58,943 --> 01:54:59,977 THINKING THAT MEET THE MISSION 3255 01:54:59,977 --> 01:55:08,285 BETTER THAN WE CURRENTLY ARE. 3256 01:55:08,285 --> 01:55:14,325 LET ME TALK A LITTLE BIT ABOUT A 3257 01:55:14,325 --> 01:55:15,526 FEW EARLY INITIATIVES I'VE 3258 01:55:15,526 --> 01:55:16,861 WORKED ON. 3259 01:55:16,861 --> 01:55:19,130 THE FIRST IS AN INITIATIVE 3260 01:55:19,130 --> 01:55:20,231 REQUESTED BY THE PRESIDENT OF 3261 01:55:20,231 --> 01:55:21,999 THE UNITED STATES TO SECRETARY 3262 01:55:21,999 --> 01:55:23,400 KENNEDY AND THEN TRANSMITTED TO 3263 01:55:23,400 --> 01:55:27,004 ME TO HAVE A -- TO INITIATE A 3264 01:55:27,004 --> 01:55:28,772 RESEARCH PROGRAM SO WE HAVE A 3265 01:55:28,772 --> 01:55:31,375 BETTER UNDERSTANDING OF THE 3266 01:55:31,375 --> 01:55:34,879 ETIOLOGY OF THE AUTISM SPECTRUM 3267 01:55:34,879 --> 01:55:37,615 DISORDERS AS WELL AS ASSOCIATED 3268 01:55:37,615 --> 01:55:38,115 CONDITIONS. 3269 01:55:38,115 --> 01:55:40,117 TO DO THIS, THE NIH IS LAUNCHING 3270 01:55:40,117 --> 01:55:43,154 A INITIATIVE INSIDE THE OFFICE 3271 01:55:43,154 --> 01:55:45,823 OF THE DIRECTOR WHERE THE GOAL 3272 01:55:45,823 --> 01:55:49,426 IS TO INTEGRATE DIVERSE DATA 3273 01:55:49,426 --> 01:55:50,961 ENABLING RESEARCHERS TO EXAMINE 3274 01:55:50,961 --> 01:55:52,496 COMPLEX FACTORS INFLUENCING THE 3275 01:55:52,496 --> 01:55:54,265 RAPID RISE IN AUTISM SPECTRUM 3276 01:55:54,265 --> 01:55:58,169 DISORDER. 3277 01:55:58,169 --> 01:56:02,773 IN 2022, THE MMWR AT THE CDC 3278 01:56:02,773 --> 01:56:04,642 ESTIMATED THAT AUTISM SPECTRUM 3279 01:56:04,642 --> 01:56:06,177 DISORDER -- THAT 1 IN 3280 01:56:06,177 --> 01:56:07,411 31 CHILDREN HAD SOME FORM OF 3281 01:56:07,411 --> 01:56:10,447 AUTISM SPECTRUM DISORDER, A VERY 3282 01:56:10,447 --> 01:56:12,716 SHARP INCREASE FROM PREVIOUS 3283 01:56:12,716 --> 01:56:13,184 YEARS. 3284 01:56:13,184 --> 01:56:15,252 AUTISM SPECTRUM DISORDER IS A 3285 01:56:15,252 --> 01:56:21,592 HIGHLY HET YOE GEE JUST 3286 01:56:21,592 --> 01:56:23,027 HIGH DRK DEVELOPING TREATMENTS 3287 01:56:23,027 --> 01:56:27,398 FOR THE RANGE OF CONDITIONS THAT 3288 01:56:27,398 --> 01:56:29,366 THIS DISORDER REPRESENTS. 3289 01:56:29,366 --> 01:56:31,769 THE NIH IS COMMITTED TO IDENTIFY 3290 01:56:31,769 --> 01:56:33,837 CAUSES, RISK FACTORS AND 3291 01:56:33,837 --> 01:56:34,705 TREATMENTS THROUGH INVESTMENTS 3292 01:56:34,705 --> 01:56:35,906 IN RESEARCH PROGRAMS, 3293 01:56:35,906 --> 01:56:37,675 COORDINATION OF INTERAGENCY 3294 01:56:37,675 --> 01:56:40,077 ACTIVITIES, AND COLLABORATION 3295 01:56:40,077 --> 01:56:42,146 WITH THE AUTISM COMMUNITY. 3296 01:56:42,146 --> 01:56:45,916 TO THIS END, WE'RE LAUNCHING AN 3297 01:56:45,916 --> 01:56:47,384 INITIATIVE TO ACCELERATE THE 3298 01:56:47,384 --> 01:56:50,020 UNDERSTANDING OF CAUSES AND 3299 01:56:50,020 --> 01:56:50,721 IMPROVEMENTS IN TREATMENT. 3300 01:56:50,721 --> 01:56:53,324 THIS NEW INITIATIVE WILL 3301 01:56:53,324 --> 01:56:54,725 IMPLEMENT LARGE SCALE EXISTING 3302 01:56:54,725 --> 01:56:57,361 DATA RESOURCES, AS WELL AS 3303 01:56:57,361 --> 01:56:58,562 RESOURCES -- DATA RESOURCES THAT 3304 01:56:58,562 --> 01:56:59,997 ARE AVAILABLE IN THE -- 3305 01:56:59,997 --> 01:57:01,198 THROUGHOUT THE REST OF THE 3306 01:57:01,198 --> 01:57:02,600 FEDERAL GOVERNMENT AS WELL AS 3307 01:57:02,600 --> 01:57:03,934 THE PRIVATE SECTOR. 3308 01:57:03,934 --> 01:57:07,104 IF NEEDED, THE RESEARCHERS CAN 3309 01:57:07,104 --> 01:57:10,374 GENERATE NEW DATA THAT WILL LINK 3310 01:57:10,374 --> 01:57:15,079 TO THESE AND OPEN LEEM QUERY 3311 01:57:15,079 --> 01:57:17,147 CONTRIBUTIONS, RISK FACTORS OF 3312 01:57:17,147 --> 01:57:18,682 AUTISM. 3313 01:57:18,682 --> 01:57:25,022 TO DO THIS, WE WILL USE A RAPID 3314 01:57:25,022 --> 01:57:31,795 TIMELINE OF A LARGE GRANT, GRANT 3315 01:57:31,795 --> 01:57:32,997 PROCESS THAT WILL BE RUN THROUGH 3316 01:57:32,997 --> 01:57:34,865 THE OFFICE OF THE DIRECTOR. 3317 01:57:34,865 --> 01:57:39,737 WE WILL SUBJECT THE -- THE 3318 01:57:39,737 --> 01:57:41,205 EXTRAMURAL RESEARCHERS WHO APPLY 3319 01:57:41,205 --> 01:57:42,840 WILL BE SUBJECT TO NORMAL REVIEW 3320 01:57:42,840 --> 01:57:44,275 PROCESSES AND HAVE ACCESS TO THE 3321 01:57:44,275 --> 01:57:46,010 DATA RESOURCES WHICH I'LL 3322 01:57:46,010 --> 01:57:49,313 MENTION IN JUST A SECOND. 3323 01:57:49,313 --> 01:57:51,715 THE IDEA WOULD BE THAT SOMEWHERE 3324 01:57:51,715 --> 01:57:53,250 BETWEEN 10 TO 20 GROUPS OF 3325 01:57:53,250 --> 01:57:54,785 RESEARCHERS FROM ACROSS THE 3326 01:57:54,785 --> 01:57:56,320 COUNTRY, AGAIN, RUN THROUGH 3327 01:57:56,320 --> 01:57:59,356 NORMAL NIH PROCESSES, WOULD BE 3328 01:57:59,356 --> 01:58:02,426 ABLE TO ASK QUESTIONS USING 3329 01:58:02,426 --> 01:58:04,194 METHODS RANGING FROM BASIC 3330 01:58:04,194 --> 01:58:06,930 SCIENCE TO EPIDEMIOLOGICAL 3331 01:58:06,930 --> 01:58:12,069 APPROACHES TO OTHER MORE APPLIED 3332 01:58:12,069 --> 01:58:15,105 APPROACHES TO ASK WHAT CAUSES 3333 01:58:15,105 --> 01:58:18,942 AUTISM AND ANSWERS HOW BEST CAN 3334 01:58:18,942 --> 01:58:21,812 WE TREAT AND MANAGE AUTISM SO 3335 01:58:21,812 --> 01:58:24,548 THAT SO MANY MILLIONS OF 3336 01:58:24,548 --> 01:58:26,016 FAMILIES HAVE AN EASIER TIME 3337 01:58:26,016 --> 01:58:28,552 DEALING WITH THE PROBLEMS CAUSED 3338 01:58:28,552 --> 01:58:35,693 BY HAVING AN AUTISTIC CHILD. 3339 01:58:35,693 --> 01:58:37,361 I RECOGNIZE, OF COURSE, THAT 3340 01:58:37,361 --> 01:58:38,762 AUTISM IS A RANGE OF 3341 01:58:38,762 --> 01:58:40,931 MANIFESTATIONS RANGING FROM 3342 01:58:40,931 --> 01:58:44,101 HIGHLY FUNCTIONING CHILDREN TO 3343 01:58:44,101 --> 01:58:46,737 CHILDREN THAT ARE QUITE SEVERELY 3344 01:58:46,737 --> 01:58:47,938 DISABLED, AND OF COURSE THE 3345 01:58:47,938 --> 01:58:49,740 RESEARCH WILL ACCOUNT VERY 3346 01:58:49,740 --> 01:58:53,177 CAREFULLY FOR THOSE 3347 01:58:53,177 --> 01:58:54,078 DISTINCTIONS, THE HIGHEST 3348 01:58:54,078 --> 01:58:55,145 QUALITY PROPOSALS. 3349 01:58:55,145 --> 01:58:57,448 TO MAKE THIS HAPPEN, WHAT WE'RE 3350 01:58:57,448 --> 01:59:00,184 GOING TO DO AT THE NIH IS LAUNCH 3351 01:59:00,184 --> 01:59:03,854 A REAL WORLD DATA PLATFORM. 3352 01:59:03,854 --> 01:59:06,090 THE IDEA OF THE PLATFORM IS THAT 3353 01:59:06,090 --> 01:59:09,159 THE EXISTING DATA RESOURCES ARE 3354 01:59:09,159 --> 01:59:10,694 OFTEN FRAGMENTED AND DIFFICULT 3355 01:59:10,694 --> 01:59:11,228 TO OBTAIN. 3356 01:59:11,228 --> 01:59:14,498 THE NIH ITSELF WILL OFTEN PAY 3357 01:59:14,498 --> 01:59:16,500 MULTIPLE TIMES FOR THE SAME DATA 3358 01:59:16,500 --> 01:59:17,701 RESOURCE EVEN DATA RESOURCES 3359 01:59:17,701 --> 01:59:20,437 THAT ARE WITHIN THE FEDERAL 3360 01:59:20,437 --> 01:59:21,438 GOVERNMENT, ARE DIFFICULT TO 3361 01:59:21,438 --> 01:59:23,807 OBTAIN AND USE BY RESEARCHERS. 3362 01:59:23,807 --> 01:59:26,110 SO WHAT WE'RE PROPOSING IS A 3363 01:59:26,110 --> 01:59:27,211 TRANSFORMATIVE REAL WORLD DATA 3364 01:59:27,211 --> 01:59:28,112 INITIATIVE WHICH AIMS TO PROVIDE 3365 01:59:28,112 --> 01:59:30,814 A ROBUST AND SECURE 3366 01:59:30,814 --> 01:59:32,216 COMPUTATIONAL AND DATA PLATFORM 3367 01:59:32,216 --> 01:59:33,550 FOR CHRONIC DISEASE AND AUTISM 3368 01:59:33,550 --> 01:59:34,318 RESEARCH. 3369 01:59:34,318 --> 01:59:37,054 THIS DATA PLATFORM WILL BE 3370 01:59:37,054 --> 01:59:39,123 UNVEILED AND USED FOR THE AUTISM 3371 01:59:39,123 --> 01:59:40,758 INITIATIVE AS I MENTIONED 3372 01:59:40,758 --> 01:59:42,192 EARLIER, WILL ALSO BE AVAILABLE 3373 01:59:42,192 --> 01:59:43,594 FOR OTHER RESEARCH PROGRAMS 3374 01:59:43,594 --> 01:59:45,996 WITHIN THE NIH ON CHRONIC 3375 01:59:45,996 --> 01:59:47,431 DISEASE AND OTHER TOPICS. 3376 01:59:47,431 --> 01:59:49,199 THE PLATFORM WILL FACILITATE 3377 01:59:49,199 --> 01:59:51,602 COLLABORATION ACROSS THE 3378 01:59:51,602 --> 01:59:52,903 DEPARTMENT OF HEALTH AND HUMAN 3379 01:59:52,903 --> 01:59:54,438 SERVICES AND GOVERNMENT MORE 3380 01:59:54,438 --> 01:59:56,940 BROADLY TO ESTABLISH 3381 01:59:56,940 --> 01:59:58,475 COMPREHENSIVE HEALTH DATASETS. 3382 01:59:58,475 --> 02:00:00,244 THIS WILL INCLUDE CLAIMS DATA 3383 02:00:00,244 --> 02:00:02,413 FROM MEDICARE, MEDICAID, WE'RE 3384 02:00:02,413 --> 02:00:03,847 WORKING ON A MEMORANDUM OF 3385 02:00:03,847 --> 02:00:07,551 UNDERSTANDING WITH CMS TO 3386 02:00:07,551 --> 02:00:09,086 ESTABLISH BROADER DATA USE 3387 02:00:09,086 --> 02:00:10,254 AGREEMENTS WITHIN THE NIH FOR 3388 02:00:10,254 --> 02:00:12,923 THAT PURPOSE. 3389 02:00:12,923 --> 02:00:14,458 IT WILL INCLUDE ELECTRONIC 3390 02:00:14,458 --> 02:00:16,093 HEALTH RECORD DATA FROM THE 3391 02:00:16,093 --> 02:00:19,496 PRIVATE SECTOR. 3392 02:00:19,496 --> 02:00:23,434 IT WILL INCLUDE OTHER CLAIMS, 3393 02:00:23,434 --> 02:00:25,936 EXISTING DATA RESOURCES SUCH AS 3394 02:00:25,936 --> 02:00:28,906 THE GENETICS DATA THAT THE NIH 3395 02:00:28,906 --> 02:00:30,307 HAS, AS WELL AS TOXICOLOGY DATA 3396 02:00:30,307 --> 02:00:31,942 AND ENVIRONMENTAL EXPOSURE DATA 3397 02:00:31,942 --> 02:00:34,478 FROM ACROSS THE GOVERNMENT AND 3398 02:00:34,478 --> 02:00:36,113 PRIVATE RESOURCE -- PRIVATE 3399 02:00:36,113 --> 02:00:37,548 INDUSTRY. 3400 02:00:37,548 --> 02:00:42,820 MANY LEADERS IN THE DATA SCIENCE 3401 02:00:42,820 --> 02:00:46,190 SPACE -- ACROSS THE ICs AND SO 3402 02:00:46,190 --> 02:00:51,528 THIS PLATFORM LANDL WILL FEATURE 3403 02:00:51,528 --> 02:00:52,963 CUTTING EDGE KNOWLEDGE THAT THE 3404 02:00:52,963 --> 02:00:56,333 NIH ALREADY HAS. 3405 02:00:56,333 --> 02:00:57,868 IF YOU LOOK ON THIS FIGURE YOU 3406 02:00:57,868 --> 02:01:00,070 CAN SEE THE PLATFORM WILL LINK 3407 02:01:00,070 --> 02:01:01,071 DATA FROM REAL WORLD SOURCES 3408 02:01:01,071 --> 02:01:02,372 SUCH AS PHARMACY CHAINS SO YOU 3409 02:01:02,372 --> 02:01:04,708 HAVE MEDICATION RECORDS, HEALTH 3410 02:01:04,708 --> 02:01:06,510 ORGANIZATIONS LIKE INCLUDING THE 3411 02:01:06,510 --> 02:01:08,278 V.A., DEFENSE HEALTH AGENCY, 3412 02:01:08,278 --> 02:01:10,247 INDIAN HEALTH SERVICES, CLINICAL 3413 02:01:10,247 --> 02:01:12,516 DATA AS I ALREADY MENTIONED, THE 3414 02:01:12,516 --> 02:01:13,417 ELECTRONIC HEALTH RECORD SO YOU 3415 02:01:13,417 --> 02:01:16,186 HAVE ACCESS TO LABS, IMAGING, 3416 02:01:16,186 --> 02:01:17,454 GENOMICS, CLAIMS AND BILLING 3417 02:01:17,454 --> 02:01:19,756 DATA, WHICH OFTEN PROVIDES 3418 02:01:19,756 --> 02:01:21,592 DETAILED DIAGNOSTIC INFORMATION 3419 02:01:21,592 --> 02:01:23,794 AS WELL AS INFORMATION ABOUT USE 3420 02:01:23,794 --> 02:01:26,630 OF OCCUPATIONAL HEALTH AND OTHER 3421 02:01:26,630 --> 02:01:27,197 RESOURCES. 3422 02:01:27,197 --> 02:01:29,500 ENVIRONMENTAL DATA, AIR 3423 02:01:29,500 --> 02:01:30,601 POLLUTION, ENVIRONMENTAL TOXINS, 3424 02:01:30,601 --> 02:01:33,303 AS WELL AS SOME DATA ON SENSORS 3425 02:01:33,303 --> 02:01:34,938 AND WEARABLES LIKE SMART WATCHES 3426 02:01:34,938 --> 02:01:36,006 AND FITNESS TRACKERS. 3427 02:01:36,006 --> 02:01:37,241 BY BRINGING THESE DATA TOGETHER 3428 02:01:37,241 --> 02:01:38,675 IN ONE PLACE, PROVIDING ACCESS 3429 02:01:38,675 --> 02:01:39,977 TO ADVANCED COMPUTATION 3430 02:01:39,977 --> 02:01:41,078 RESOURCES AND LEVERAGING THE 3431 02:01:41,078 --> 02:01:44,581 LATEST TECHNIQUES, AI 3432 02:01:44,581 --> 02:01:46,016 TECHNIQUES, THE PLATFORM WILL 3433 02:01:46,016 --> 02:01:48,185 ACCELERATE RESEARCH AND CREATE 3434 02:01:48,185 --> 02:01:49,720 NEW OPPORTUNITIES IN REALTIME 3435 02:01:49,720 --> 02:01:51,455 HEALTH MONITORING DEVELOPING 3436 02:01:51,455 --> 02:01:53,323 NATIONAL DISEASE REGISTRIES 3437 02:01:53,323 --> 02:01:55,959 INCLUDING A NEW ONE FOR AUTISM, 3438 02:01:55,959 --> 02:01:58,262 ENABLING FASTER DRUG 3439 02:01:58,262 --> 02:01:59,363 DEVELOPMENT, ENABLE LONGITUDINAL 3440 02:01:59,363 --> 02:02:00,430 DATASETS TO BETTER UNDERSTAND 3441 02:02:00,430 --> 02:02:02,199 THE PROGRESSION OF DISEASE AND 3442 02:02:02,199 --> 02:02:05,269 LAUNCHING NATIONAL COMPETITIONS 3443 02:02:05,269 --> 02:02:07,638 AS WELL AS RESEARCH PROGRAMS FOR 3444 02:02:07,638 --> 02:02:09,840 INNOVATIVE AND CUTTING EDGE 3445 02:02:09,840 --> 02:02:11,308 RESEARCH TO ANSWER KEY QUESTIONS 3446 02:02:11,308 --> 02:02:12,743 SUCH AS THE ONE ON THE ETIOLOGY 3447 02:02:12,743 --> 02:02:15,312 OF AUTISM. 3448 02:02:15,312 --> 02:02:17,614 THE REAL WORLD DATA PLATFORM 3449 02:02:17,614 --> 02:02:22,419 WILL PRESERVE THE PRIVACY OF 3450 02:02:22,419 --> 02:02:23,687 PATIENTS WITHIN THE CONTEXT OF 3451 02:02:23,687 --> 02:02:25,822 THE PLATFORM ITSELF. 3452 02:02:25,822 --> 02:02:27,024 RESEARCHERS WILL BE ABLE TO DO 3453 02:02:27,024 --> 02:02:28,458 THEIR WORK ON THE PLATFORMS BUT 3454 02:02:28,458 --> 02:02:31,061 NOT BE ABLE TO DOWNLOAD THE DATA 3455 02:02:31,061 --> 02:02:32,763 THEMSELVES, AND THERE ARE STATE 3456 02:02:32,763 --> 02:02:34,131 OF THE ART PROTECTIONS TO MAKE 3457 02:02:34,131 --> 02:02:36,433 SURE THAT ALTHOUGH LINKAGES 3458 02:02:36,433 --> 02:02:37,501 ACROSS THE DATASETS WILL BE 3459 02:02:37,501 --> 02:02:41,438 PERMITTED INSIELD INSIDE THE P, 3460 02:02:41,438 --> 02:02:43,307 THAT THESE LINKAGES DO NOT IN 3461 02:02:43,307 --> 02:02:44,741 ANY WAY THRI 10 THE 3462 02:02:44,741 --> 02:02:48,011 CONFIDENTIALITY OF PATIENTS. 3463 02:02:52,449 --> 02:02:55,118 TO DO THIS, WE WILL FORM 3464 02:02:55,118 --> 02:02:55,886 COLLABORATIVE PARTNERSHIPS WITH 3465 02:02:55,886 --> 02:02:56,653 FEDERAL, STATE AND PRIVATE 3466 02:02:56,653 --> 02:02:58,088 ENTITIES TO EXPAND DATA 3467 02:02:58,088 --> 02:03:00,757 RESOURCES AND IDENTIFY 3468 02:03:00,757 --> 02:03:02,893 OPPORTUNITIES. 3469 02:03:02,893 --> 02:03:04,628 THE PLATFORM DEVELOPMENT WILL 3470 02:03:04,628 --> 02:03:06,396 LEVERAGE EXISTING PROGRAMS AS A 3471 02:03:06,396 --> 02:03:07,831 FOWN DIETION, SUCH AS THE 3472 02:03:07,831 --> 02:03:11,001 HEALTHY BABY AND CHILD PROGRAM, 3473 02:03:11,001 --> 02:03:13,937 THE PROGRAM WHICH CURRENTLY 3474 02:03:13,937 --> 02:03:17,007 LINKS -- AND THE NCATS N3C 3475 02:03:17,007 --> 02:03:20,611 PLATFORM WIS SYSTEMATICALLY 3476 02:03:20,611 --> 02:03:21,778 DERIVES HEALTH RECORDS FROM 3477 02:03:21,778 --> 02:03:23,113 DIFFERENT INSTITUTIONS AND 3478 02:03:23,113 --> 02:03:24,548 HARMONIZES THESE INTO DATA 3479 02:03:24,548 --> 02:03:25,882 ENCLAVES. 3480 02:03:25,882 --> 02:03:28,185 WE'LL BUILD NEW PARTNERSHIPS AND 3481 02:03:28,185 --> 02:03:28,719 RESEARCH OPPORTUNITIES. 3482 02:03:28,719 --> 02:03:30,354 THE STRATEGIC APPROACH WILL 3483 02:03:30,354 --> 02:03:32,122 ENABLE AGILE IMPLEMENTATION 3484 02:03:32,122 --> 02:03:33,323 ENGAGEMENT WITH NON-TRADITIONAL 3485 02:03:33,323 --> 02:03:34,925 RESEARCH PARTNERS AND SUPPORT 3486 02:03:34,925 --> 02:03:37,027 NIH WIDE INVOLVEMENT TO DRIVE 3487 02:03:37,027 --> 02:03:37,661 PLATFORM GROWTH. 3488 02:03:37,661 --> 02:03:39,863 I'VE ALREADY REACHED OUT ACROSS 3489 02:03:39,863 --> 02:03:46,970 HHS INCLUDING TO CMS AND OARL OR 3490 02:03:46,970 --> 02:03:48,972 ENTITIES WITHIN HHS AS WELL AS 3491 02:03:48,972 --> 02:03:50,540 WITHIN NIH ITSELF AND HAVE HAD 3492 02:03:50,540 --> 02:03:51,875 NOTHING BUT ENTHUSIASM FOR 3493 02:03:51,875 --> 02:03:52,643 PARTICIPATION IN THIS. 3494 02:03:52,643 --> 02:03:54,277 WE'VE HAD A GREAT CONVERSATION 3495 02:03:54,277 --> 02:03:55,812 WITH SOME OF THE FOLKS IN 3496 02:03:55,812 --> 02:03:58,081 MILITARY HEALTH WHO ARE ALSO 3497 02:03:58,081 --> 02:03:59,416 QUITE EAGER TO GET THESE DATA IN 3498 02:03:59,416 --> 02:04:00,717 THE HANDS OF RESEARCHERS SO THAT 3499 02:04:00,717 --> 02:04:02,686 WE CAN ASK QUESTIONS AGAIN NOT 3500 02:04:02,686 --> 02:04:04,454 JUST ABOUT AUTISM BUT ABOUT A 3501 02:04:04,454 --> 02:04:06,723 WHOLE RANGE OF CONDITIONS THAT 3502 02:04:06,723 --> 02:04:08,492 WOULD BENEFIT FROM CLOSE 3503 02:04:08,492 --> 02:04:11,228 ANALYSIS OF THESE DATA BY EXPERT 3504 02:04:11,228 --> 02:04:12,496 RESEARCHERS IN THE EXTRAMURAL 3505 02:04:12,496 --> 02:04:13,296 COMMUNITY. 3506 02:04:13,296 --> 02:04:15,265 THE PROJECT WILL HAVE PREDEFINED 3507 02:04:15,265 --> 02:04:16,700 MILESTONES AND CHECKPOINTS 3508 02:04:16,700 --> 02:04:17,567 ENSURING EFFICIENT OPERATION, 3509 02:04:17,567 --> 02:04:21,071 BUT THE KEY THING IS WE WILL 3510 02:04:21,071 --> 02:04:23,907 MAKE SURE THAT THE PROCESSES 3511 02:04:23,907 --> 02:04:25,876 INSIDE TO OBTAIN AND USE THESE 3512 02:04:25,876 --> 02:04:28,278 DATA INSIDE THE REAL WORLD DATA 3513 02:04:28,278 --> 02:04:30,247 PLATFORM GUARANTEE PATIENT 3514 02:04:30,247 --> 02:04:33,850 SAFETY, PROTECTION OF PATIENT 3515 02:04:33,850 --> 02:04:34,851 CONFIDENTIALITY SO WHILE 3516 02:04:34,851 --> 02:04:38,021 RESEARCH ACCESS WILL BE EASY, 3517 02:04:38,021 --> 02:04:39,322 HARMING PATIENTS AS FAR AS THE 3518 02:04:39,322 --> 02:04:40,090 CONFIDENTIALITY IS CONCERNED 3519 02:04:40,090 --> 02:04:46,997 WILL NOT BE POSSIBLE. 3520 02:04:46,997 --> 02:04:48,398 LAST BIT OF MY TALK, I WANT TO 3521 02:04:48,398 --> 02:04:49,599 TALK ABOUT FIVE MAJOR AIMS I 3522 02:04:49,599 --> 02:04:52,903 WOULD LIKE TO ACCOMPLISH AS NIH 3523 02:04:52,903 --> 02:04:54,738 DIRECTOR, AND LET ME JUST -- I 3524 02:04:54,738 --> 02:04:56,707 PUT THIS AS A BLUEPRINT FOR THE 3525 02:04:56,707 --> 02:04:57,741 FUTURE OF BIOMEDICAL RESEARCH, 3526 02:04:57,741 --> 02:04:59,242 BECAUSE I THINK THE NIH CAN PLAY 3527 02:04:59,242 --> 02:05:02,079 A TREMENDOUSLY IMPORTANT ROLE IN 3528 02:05:02,079 --> 02:05:04,614 SHAPING WHAT THE NEXT CENTURY OF 3529 02:05:04,614 --> 02:05:06,216 BIOMEDICAL RESEARCH WILL LOOK 3530 02:05:06,216 --> 02:05:11,054 LIKE. 3531 02:05:11,054 --> 02:05:12,222 SO FIRST YOU CAN PROBABLY TELL 3532 02:05:12,222 --> 02:05:14,391 FROM THE TIME I SPENT ON THE 3533 02:05:14,391 --> 02:05:16,393 AUTISM STUDY AND ON THE REAL 3534 02:05:16,393 --> 02:05:20,030 WORLD DATA PLATFORM, THE NIH 3535 02:05:20,030 --> 02:05:24,501 ABSOLUTELY MUST ADDRESS THE CAN 3536 02:05:24,501 --> 02:05:27,370 KEY HEALTH NEEDS OF THE COUNTRY. 3537 02:05:27,370 --> 02:05:28,972 SINCE 2012, THE UNITED STATES 3538 02:05:28,972 --> 02:05:31,908 HAS HAD FLAT LIFE EXPECTANCY. 3539 02:05:31,908 --> 02:05:36,279 IN A SENSE, THE KEY MISSION OF 3540 02:05:36,279 --> 02:05:38,181 THE NIH, ONE OF THEM WHICH IS TO 3541 02:05:38,181 --> 02:05:39,149 EXPAND LONGEVITY OF THE AMERICAN 3542 02:05:39,149 --> 02:05:41,284 PEOPLE, HAS NOT BEEN ACHIEVED, 3543 02:05:41,284 --> 02:05:44,955 AND WITH THE PANDEMIC, THE LIFE 3544 02:05:44,955 --> 02:05:45,956 EXPECTANCY COLLAPSED EVEN 3545 02:05:45,956 --> 02:05:48,125 FURTHER AND ONLY RECENTLY HAS IT 3546 02:05:48,125 --> 02:05:50,961 COME BACK UP TO THE 2019 LEVELS. 3547 02:05:50,961 --> 02:05:52,729 CHRONIC DISEASE PROBLEMS 3548 02:05:52,729 --> 02:05:54,664 INCLUDING OBESE, DIABETES, HEART 3549 02:05:54,664 --> 02:05:55,999 DISEASE, I CAN GO THROUGH THE 3550 02:05:55,999 --> 02:05:59,836 WHOLE LITANY, ARE SO PREVALENT, 3551 02:05:59,836 --> 02:06:00,804 AFFLICTING THE LIVES OF MILLIONS 3552 02:06:00,804 --> 02:06:04,641 AND MILLIONS OF AMERICANS. 3553 02:06:04,641 --> 02:06:05,408 THE MAKE AMERICA HEALTHY AGAIN 3554 02:06:05,408 --> 02:06:07,377 IDEA IS SOMETHING THAT'S 3555 02:06:07,377 --> 02:06:08,979 BASICALLY UNIFORMLY POPULAR. 3556 02:06:08,979 --> 02:06:11,548 AND THE NIH MUST PLAY A ROLE IN 3557 02:06:11,548 --> 02:06:14,384 MAKING SURE THAT WE FOCUS ON 3558 02:06:14,384 --> 02:06:16,753 THOSE DISEASES THAT MOST AFFLICT 3559 02:06:16,753 --> 02:06:17,654 THE AMERICAN PEOPLE. 3560 02:06:17,654 --> 02:06:20,724 SO THAT WE CAN IMPROVE THAT 3561 02:06:20,724 --> 02:06:21,491 HEALTH -- THEIR HEALTH AND 3562 02:06:21,491 --> 02:06:22,592 ADDRESS THE NEEDS THAT THEY 3563 02:06:22,592 --> 02:06:24,728 HAVE. 3564 02:06:24,728 --> 02:06:26,630 THE KINDS OF APPROACHES WE HAVE 3565 02:06:26,630 --> 02:06:29,599 WILL AIM AT NOT JUST AT THE 3566 02:06:29,599 --> 02:06:32,602 CUTTING EDGE RESEARCH THAT 3567 02:06:32,602 --> 02:06:34,070 PRODUCES EXPENSIVE NEW 3568 02:06:34,070 --> 02:06:38,008 TREATMENTS, BUT ALSO SCALING AND 3569 02:06:38,008 --> 02:06:42,145 MAKING MORE ACCESSIBLE NEW 3570 02:06:42,145 --> 02:06:44,781 FINDINGS THAT WILL BE AVAILABLE 3571 02:06:44,781 --> 02:06:46,416 TO THE WHOLE OF THE AMERICAN 3572 02:06:46,416 --> 02:06:47,083 PEOPLE, NOT JUST A PART. 3573 02:06:47,083 --> 02:06:48,819 WE HAVE TO FIND BETTER WAYS TO 3574 02:06:48,819 --> 02:06:50,587 PREVENT, TREAT AND CURE CHRONIC 3575 02:06:50,587 --> 02:06:51,688 DISEASES. 3576 02:06:51,688 --> 02:06:54,090 OUR RESEARCHERS ARE NOT SIMPLY 3577 02:06:54,090 --> 02:06:55,692 FOCUSED ON HOW TO MANAGE LATE 3578 02:06:55,692 --> 02:06:56,827 STAGE CHRONIC DISEASE BUT ALSO 3579 02:06:56,827 --> 02:06:59,563 ON HOW BEST TO PREVENT THE 3580 02:06:59,563 --> 02:07:00,964 DEVELOPMENT OF CHRONIC DISEASE 3581 02:07:00,964 --> 02:07:02,399 AND THEN THE COMPLICATIONS OF 3582 02:07:02,399 --> 02:07:05,135 CHRONIC DISEASE ONCE IT'S IN THE 3583 02:07:05,135 --> 02:07:07,437 EARLY STAGES, AND IF WE CAN FIND 3584 02:07:07,437 --> 02:07:13,877 CURES TO DO THAT AS WELL. 3585 02:07:13,877 --> 02:07:15,612 THE SECOND TENET, THE SECOND 3586 02:07:15,612 --> 02:07:17,614 GOAL THAT I HAVE AS NIH DIRECTOR 3587 02:07:17,614 --> 02:07:21,318 IS TO SOLVE THE REPLICABILITY 3588 02:07:21,318 --> 02:07:22,919 CRISIS THAT HAS AFFLICTED 3589 02:07:22,919 --> 02:07:25,789 SCIENCE FOR DECADES NOW. 3590 02:07:25,789 --> 02:07:30,393 IN THE EARLY 2000s, MY 3591 02:07:30,393 --> 02:07:32,562 STANFORD COLLEAGUE JOHN EDES 3592 02:07:32,562 --> 02:07:34,097 WROTE A VERY FAMOUS PAPER WHERE 3593 02:07:34,097 --> 02:07:38,168 HE DOCUMENTED IN VERY SIMPLE 3594 02:07:38,168 --> 02:07:39,736 WAYS THAT LARGE CHUNKS OF THE 3595 02:07:39,736 --> 02:07:41,338 SCIENTIFIC LITERATURE SIMPLY 3596 02:07:41,338 --> 02:07:44,174 WERE NOT RELIABLE. 3597 02:07:44,174 --> 02:07:46,810 THE REPLICATION CRISIS ENSUED IN 3598 02:07:46,810 --> 02:07:49,212 FIELD AFTER FIELD HAS UNDERMINED 3599 02:07:49,212 --> 02:07:50,847 THE CONFIDENCE THAT THE PUBLIC 3600 02:07:50,847 --> 02:07:54,885 AT LARGE HAS IN THE BIOMEDICAL 3601 02:07:54,885 --> 02:07:55,418 ENTERPRISE. 3602 02:07:55,418 --> 02:07:57,854 DURING THE COVID EPIDEMIC, THIS 3603 02:07:57,854 --> 02:07:59,489 BECAME VERY, VERY SEVERE, THIS 3604 02:07:59,489 --> 02:08:01,024 PROBLEM BECAME VERY, VERY SEVERE 3605 02:08:01,024 --> 02:08:04,194 WITH THE SUPPRESSION OF ABILITY 3606 02:08:04,194 --> 02:08:07,030 FOR PEOPLE TO DISSENT AGAINST 3607 02:08:07,030 --> 02:08:08,465 SCIENTIFIC DOGMA, AND THE 3608 02:08:08,465 --> 02:08:10,767 ELEVATION OF ESSENTIALLY 3609 02:08:10,767 --> 02:08:12,068 AUTHORITY RATHER THAN 3610 02:08:12,068 --> 02:08:14,104 REPLICATION AS THE SOURCE OF 3611 02:08:14,104 --> 02:08:16,439 TRUTH IN SCIENCE. 3612 02:08:16,439 --> 02:08:17,974 I'VE HEARD FROM DRUG DEVELOPERS 3613 02:08:17,974 --> 02:08:20,377 AND MANY OTHER PEOPLE WHO TELL 3614 02:08:20,377 --> 02:08:22,779 ME THAT THEY CAN'T REALLY MAKE 3615 02:08:22,779 --> 02:08:24,447 GOOD DECISIONS BASED ON THE 3616 02:08:24,447 --> 02:08:26,049 SCIENTIFIC LITERATURE BECAUSE 3617 02:08:26,049 --> 02:08:27,284 THEY DON'T TRUST IT. 3618 02:08:27,284 --> 02:08:31,321 AND IN FACT, DRUG DEVELOPERS 3619 02:08:31,321 --> 02:08:33,623 OFTEN CONDUCT THEIR OWN PRIVATE 3620 02:08:33,623 --> 02:08:34,491 REPLICATION EXERCISES IN ORDER 3621 02:08:34,491 --> 02:08:37,894 TO SEE WHETHER IT'S WORTH 3622 02:08:37,894 --> 02:08:40,664 INVESTING IN THE RESEARCH -- IN 3623 02:08:40,664 --> 02:08:42,132 THE SORT OF FOLLOW-ON FROM THE 3624 02:08:42,132 --> 02:08:43,466 RESEARCH ON WHICH -- IF THEY 3625 02:08:43,466 --> 02:08:45,969 CAN'T TRUST THE BASIC RESEARCH 3626 02:08:45,969 --> 02:08:47,504 BEFORE THEY MAKE THE 3627 02:08:47,504 --> 02:08:48,505 INVESTMENTS, THEY HAVE TO 3628 02:08:48,505 --> 02:08:49,906 REPLICATE IT THEMSELVES. 3629 02:08:49,906 --> 02:08:52,208 BUT THESE PRIVATE REPLICATION 3630 02:08:52,208 --> 02:08:53,877 EFFORTS DO NOT BENEFIT THE 3631 02:08:53,877 --> 02:08:54,611 BROADER SCIENTIFIC COMMUNITY. 3632 02:08:54,611 --> 02:08:57,314 WHAT I INTEND TO DO AS NIH 3633 02:08:57,314 --> 02:09:01,184 DIRECTOR IS TO RESTORE 3634 02:09:01,184 --> 02:09:02,819 REPLICATION AND REPRODUCIBILITY 3635 02:09:02,819 --> 02:09:05,655 OF RESEARCH AS THE CORE IDEA OF 3636 02:09:05,655 --> 02:09:11,027 WHAT IS SEEN AS TRUE IN SCIENCE. 3637 02:09:11,027 --> 02:09:13,530 IN THE PAST FEW YEARS, WE'VE 3638 02:09:13,530 --> 02:09:18,668 SEEN SO MANY EPISODES OF PEOPLE, 3639 02:09:18,668 --> 02:09:20,870 VERY PROMINENT PEOPLE ACCUSED OF 3640 02:09:20,870 --> 02:09:23,173 ESSENTIALLY RESEARCH FRAUD, 3641 02:09:23,173 --> 02:09:25,608 PEOPLE WHO HAVE LOST POSITIONS 3642 02:09:25,608 --> 02:09:28,311 INSIDE THE NIH ITSELF TO THESE 3643 02:09:28,311 --> 02:09:28,645 ACCUSATIONS. 3644 02:09:28,645 --> 02:09:32,782 WHEN YOU SEE SO MANY PEOPLE 3645 02:09:32,782 --> 02:09:35,418 FACING THIS EXACT SITUATION OF 3646 02:09:35,418 --> 02:09:37,153 RESEARCH FRAUD, THE PROBLEM THEN 3647 02:09:37,153 --> 02:09:39,456 IS NOT ACTUALLY ONE OF MORAL 3648 02:09:39,456 --> 02:09:40,991 FAILURE BY ANY INDIVIDUAL 3649 02:09:40,991 --> 02:09:42,659 SCIENTIST, BUT RATHER SYSTEMIC 3650 02:09:42,659 --> 02:09:45,362 FAILURE THAT PLACES RAPID 3651 02:09:45,362 --> 02:09:46,463 PUBLICATION OF RESULTS IN 3652 02:09:46,463 --> 02:09:48,531 PROMINENT PLACES AS AN INFLUENCE 3653 02:09:48,531 --> 02:09:51,568 AS THE WAY TO GET AHEAD IN 3654 02:09:51,568 --> 02:09:54,104 SCIENCE RATHER THAN THE 3655 02:09:54,104 --> 02:09:56,106 ESTABLISHMENT OF TRUE 3656 02:09:56,106 --> 02:09:58,408 SCIENTIFIC -- TRUE SCIENTIFIC 3657 02:09:58,408 --> 02:10:00,810 FACTS, RELIABLE, REPRODUCIBLE 3658 02:10:00,810 --> 02:10:02,312 SCIENTIFIC FACTS, FACTS 3659 02:10:02,312 --> 02:10:03,413 REPRODUCED BY OTHER GROUPS AS 3660 02:10:03,413 --> 02:10:04,748 THE BASIS FOR ADVANCE IN 3661 02:10:04,748 --> 02:10:05,615 SCIENCE. 3662 02:10:05,615 --> 02:10:11,721 TO CHANGE THIS, I INTEND TO HAVE 3663 02:10:11,721 --> 02:10:12,722 REPLICATION BECOME A CORE 3664 02:10:12,722 --> 02:10:15,892 ACTIVITY OF THE NIH, AND TO 3665 02:10:15,892 --> 02:10:18,395 REWARD SCIENTISTS WHO 3666 02:10:18,395 --> 02:10:19,596 PARTICIPATE IN REPLICATION 3667 02:10:19,596 --> 02:10:21,031 EFFORTS. 3668 02:10:21,031 --> 02:10:26,503 SO FOR EXAMPLE, I INTEND TO ASK 3669 02:10:26,503 --> 02:10:28,705 EVERY INSTITUTE TO ESTABLISH 3670 02:10:28,705 --> 02:10:30,640 THEIR OWN STANDARDS FOR WHAT 3671 02:10:30,640 --> 02:10:31,408 REPLICATION LOOKS LIKE IN THE 3672 02:10:31,408 --> 02:10:36,346 FIELDS THAT THEY COVER, TO FUND 3673 02:10:36,346 --> 02:10:41,718 RESEARCHERS AT OUR LEVEL WHO DO 3674 02:10:41,718 --> 02:10:42,786 REPLICATION WORK WITH THE 3675 02:10:42,786 --> 02:10:43,787 SCIENTIFIC COMMUNITY AT LARGE 3676 02:10:43,787 --> 02:10:45,188 COMPETING TO ASK WHAT ARE THE 3677 02:10:45,188 --> 02:10:46,056 KEY SCIENTIFIC CLAIMS IN THE 3678 02:10:46,056 --> 02:10:47,590 LITERATURE THAT NEED 3679 02:10:47,590 --> 02:10:50,026 REPLICATION, CLAIMS ON WHICH 3680 02:10:50,026 --> 02:10:51,661 PEOPLE MAKE DECISIONS ABOUT DRUG 3681 02:10:51,661 --> 02:10:52,629 DEVELOPMENT, PEOPLE MAKE 3682 02:10:52,629 --> 02:10:53,496 DECISIONS ABOUT THEIR HEALTH, 3683 02:10:53,496 --> 02:10:54,697 AND PEOPLE MAKE DECISIONS ABOUT 3684 02:10:54,697 --> 02:10:56,232 WHAT THE NEXT SCIENTIFIC STEPS 3685 02:10:56,232 --> 02:10:59,169 OUGHT TO BE. 3686 02:10:59,169 --> 02:11:00,603 THE PRACTICE OF DOING 3687 02:11:00,603 --> 02:11:01,805 REPLICATION WILL BE BECOME 3688 02:11:01,805 --> 02:11:03,473 SOMETHING THAT'S NORMALIZED IN 3689 02:11:03,473 --> 02:11:04,140 THE SCIENTIFIC COMMUNITY UNDER 3690 02:11:04,140 --> 02:11:05,442 MY WATCH. 3691 02:11:05,442 --> 02:11:06,843 SECOND, THE PROBLEM WITH 3692 02:11:06,843 --> 02:11:07,610 REPLICATION OFTEN IS THAT 3693 02:11:07,610 --> 02:11:12,982 THERE'S NO PLACE TO PUBLISH OR 3694 02:11:12,982 --> 02:11:13,950 GAIN SCIENTIFIC REWARDS FOR 3695 02:11:13,950 --> 02:11:14,517 HAVING DONE IT. 3696 02:11:14,517 --> 02:11:16,853 AT THE NIH, WE'RE GOING TO 3697 02:11:16,853 --> 02:11:19,522 ESTABLISH A JOURNAL OF WHERE 3698 02:11:19,522 --> 02:11:22,826 PEOPLE WHO ARE NIH-FUNDED AND 3699 02:11:22,826 --> 02:11:25,328 OTHERS CAN PLACE THEIR 3700 02:11:25,328 --> 02:11:25,762 REPLICATION WORK. 3701 02:11:25,762 --> 02:11:27,630 IT WILL BE A PEER-REVIEWED 3702 02:11:27,630 --> 02:11:31,801 JOURNAL WITH LOW GATE KEEPING SO 3703 02:11:31,801 --> 02:11:32,569 REPLICATION EFFORTS CAN HAPPEN 3704 02:11:32,569 --> 02:11:34,304 BUT IN THE CONTEXT OF A 3705 02:11:34,304 --> 02:11:37,273 SCIENTIFIC DISCUSSION ABOUT THE 3706 02:11:37,273 --> 02:11:38,908 REASONS WHY A STUDY DOESN'T 3707 02:11:38,908 --> 02:11:40,343 REPLICATE, WHAT THE NEXT STEPS 3708 02:11:40,343 --> 02:11:43,613 FOR IT SHOULD BE FOR RESEARCH 3709 02:11:43,613 --> 02:11:45,048 THAT DOES AND SO ON. 3710 02:11:45,048 --> 02:11:49,152 THERE WIT WILL BE A RESOURCE WHE 3711 02:11:49,152 --> 02:11:51,287 PEOPLE WHO ENGAGE AND WORK ON 3712 02:11:51,287 --> 02:11:52,689 REPLICATION CAN GAIN THE KINDS 3713 02:11:52,689 --> 02:11:54,023 OF SCIENTIFIC REWARDS THAT ARE 3714 02:11:54,023 --> 02:11:55,325 NOW NOT AVAILABLE TO THEM SINCE 3715 02:11:55,325 --> 02:11:57,527 TOP JOURNALS WILL NOT GENERALLY 3716 02:11:57,527 --> 02:11:59,162 PUBLISH REPLICATION WORK. 3717 02:11:59,162 --> 02:12:01,564 THIRD, AND THIS IS THE MOST 3718 02:12:01,564 --> 02:12:02,999 IMPORTANT REFORM I WANT TO 3719 02:12:02,999 --> 02:12:06,035 IMPLEMENT, AS THINGS 3720 02:12:06,035 --> 02:12:07,370 CURRENTLY -- AS REPLICATION 3721 02:12:07,370 --> 02:12:08,238 GOES. 3722 02:12:08,238 --> 02:12:09,672 AS THINGS CURRENTLY STAND, 3723 02:12:09,672 --> 02:12:10,507 RESEARCHERS WHO ARE SUBJECT TO 3724 02:12:10,507 --> 02:12:14,010 REREPLICATION, EVEN THE REQUEST 3725 02:12:14,010 --> 02:12:15,545 FOR REPLICATION IS A THREAT, 3726 02:12:15,545 --> 02:12:17,180 INSTEAD OF THE GREAT HONOR IT 3727 02:12:17,180 --> 02:12:18,181 ACTUALLY REPRESENTS. 3728 02:12:18,181 --> 02:12:22,118 WHEN A SCIENTIST HAS AN IDEA AND 3729 02:12:22,118 --> 02:12:24,320 IS APPROACHED BY ANOTHER 3730 02:12:24,320 --> 02:12:25,622 RESEARCHER FOR REPLICATION, THAT 3731 02:12:25,622 --> 02:12:28,358 SHOULD BE SEEN AS AN HONOR. 3732 02:12:28,358 --> 02:12:31,427 RATHER THAN A THREAT. 3733 02:12:31,427 --> 02:12:32,529 THE SCIENTIST WHO'S BEING 3734 02:12:32,529 --> 02:12:34,164 APPROACHED FOR REPLICATION 3735 02:12:34,164 --> 02:12:35,999 SHOULD RECEIVE REWARDS FOR THAT. 3736 02:12:35,999 --> 02:12:37,333 JUST THE KIND OF REWARDS THAT 3737 02:12:37,333 --> 02:12:38,668 YOU WOULD GAIN FROM A CITATION, 3738 02:12:38,668 --> 02:12:40,270 FOR INSTANCE, FOR A SCIENTIFIC 3739 02:12:40,270 --> 02:12:41,471 PAPER. 3740 02:12:41,471 --> 02:12:43,673 THE SCIENTISTS WHO COOPERATE 3741 02:12:43,673 --> 02:12:46,075 WITH THE REPLICATION EFFORTS, 3742 02:12:46,075 --> 02:12:48,044 SHARE DATA TRANSPARENTLY AND 3743 02:12:48,044 --> 02:12:50,013 ENGAGE IN GOOD FAITH IN THESE 3744 02:12:50,013 --> 02:12:51,247 REPLICATIONS, AGAIN, SHOULD BE 3745 02:12:51,247 --> 02:12:52,949 REWARDED. 3746 02:12:52,949 --> 02:12:54,817 I'M GOING TO STAND UP A NEW 3747 02:12:54,817 --> 02:12:57,120 OFFICE WITHIN THE OFFICE OF THE 3748 02:12:57,120 --> 02:13:00,390 DIRECTOR OF THE NIH TO MEASURE 3749 02:13:00,390 --> 02:13:04,661 THESE KINDS OF SCIENTIFIC -- 3750 02:13:04,661 --> 02:13:05,762 WE'LL TAKE ADVANTAGE OF OTHER 3751 02:13:05,762 --> 02:13:06,863 PARTS OF THE NIH OFFICE OF THE 3752 02:13:06,863 --> 02:13:08,064 DIRECTOR THAT FOCUS ON 3753 02:13:08,064 --> 02:13:09,365 MEASUREMENT OF SCIENTIFIC 3754 02:13:09,365 --> 02:13:10,366 PRODUCTIVITY, BUT EXPAND THE 3755 02:13:10,366 --> 02:13:12,969 SCOPE TO INCLUDE PARTICIPATION 3756 02:13:12,969 --> 02:13:16,139 AND COOPERATION WITH RESEARCH, 3757 02:13:16,139 --> 02:13:18,007 WITH REPLICATION EFFORTS, DATA 3758 02:13:18,007 --> 02:13:19,342 SHARING AND SO ON. 3759 02:13:19,342 --> 02:13:21,844 THE IDEA WOULD BE THAT BY 3760 02:13:21,844 --> 02:13:23,613 MEASURING THESE SORTS OF PRO 3761 02:13:23,613 --> 02:13:25,348 SOCIAL ACTIVITIES, THOSE PRO 3762 02:13:25,348 --> 02:13:28,184 SOCIAL ACTIVITIES WILL BE 3763 02:13:28,184 --> 02:13:29,719 REWARDED IN THE BROADER 3764 02:13:29,719 --> 02:13:30,286 SCIENTIFIC COMMUNITY. 3765 02:13:30,286 --> 02:13:31,487 TO TURN AROUND THE CURRENT 3766 02:13:31,487 --> 02:13:33,790 SITUATION, WHICH ESSENTIALLY HAS 3767 02:13:33,790 --> 02:13:35,191 REPLICATION SIDELINED AND VIEWED 3768 02:13:35,191 --> 02:13:36,960 AS A THREAT BY PEOPLE BEING 3769 02:13:36,960 --> 02:13:37,927 REPLICATED AND SOMETHING THAT'S 3770 02:13:37,927 --> 02:13:39,262 CENTRAL AND CORE TO THE 3771 02:13:39,262 --> 02:13:41,531 SCIENTIFIC ENTERPRISE, SO THAT 3772 02:13:41,531 --> 02:13:42,865 THE SCIENTISTS THEMSELVES WILL 3773 02:13:42,865 --> 02:13:44,701 WANT TO BE REPLICATED, WILL SEEK 3774 02:13:44,701 --> 02:13:45,802 THAT REPLICATION BECAUSE IT WILL 3775 02:13:45,802 --> 02:13:49,205 BE THE MAIN WAY THAT SCIENTIFIC 3776 02:13:49,205 --> 02:13:51,274 CAREERS ADVANCE. 3777 02:13:51,274 --> 02:13:53,910 THE EFFECT ON FRAUD, WELL, IT 3778 02:13:53,910 --> 02:13:57,614 WILL UNDERCUT THE INCENTIVES TO 3779 02:13:57,614 --> 02:13:59,682 COMMIT FRAUD BECAUSE THERE WILL 3780 02:13:59,682 --> 02:14:01,451 BE VERY LITTLE REWARD FOR HAVING 3781 02:14:01,451 --> 02:14:03,086 PUBLISHED A PAPER THAT ISN'T 3782 02:14:03,086 --> 02:14:13,296 REPLICATED. 3783 02:14:14,964 --> 02:14:16,766 THIRD, IN WORK I'D DONE PRIOR TO 3784 02:14:16,766 --> 02:14:18,835 THE PANDEMIC, I ANALYZED THE NIH 3785 02:14:18,835 --> 02:14:19,836 PORTFOLIO OF RESEARCH ASKING HOW 3786 02:14:19,836 --> 02:14:21,571 NEW ARE THE IDEAS THAT 3787 02:14:21,571 --> 02:14:23,206 NIH-FUNDED RESEARCH ACTUALLY 3788 02:14:23,206 --> 02:14:23,473 SUPPORTS? 3789 02:14:23,473 --> 02:14:28,244 IN THE 1980s, IT TURNS OUT BY 3790 02:14:28,244 --> 02:14:31,314 MEASURES OF NOVELTY OF RESEARCH 3791 02:14:31,314 --> 02:14:32,515 IDEAS AND RESEARCH PAPERS, IT 3792 02:14:32,515 --> 02:14:35,551 TURNS OUT THAT SCIENTISTS IN THE 3793 02:14:35,551 --> 02:14:37,854 1980s FUNDED BY NIH TENDED TO 3794 02:14:37,854 --> 02:14:40,390 WORK ON IDEAS THAT HAD BEEN 3795 02:14:40,390 --> 02:14:42,558 INTRODUCED ONLY THE YEAR OR TWO 3796 02:14:42,558 --> 02:14:43,092 PREVIOUSLY. 3797 02:14:43,092 --> 02:14:44,127 THEY WERE AT THE VERY CUTTING 3798 02:14:44,127 --> 02:14:44,761 EDGE OF RESEARCH. 3799 02:14:44,761 --> 02:14:47,063 WITH A FEW EXCEPTIONS IN THE 3800 02:14:47,063 --> 02:14:50,433 2010s, THE NIH RESEARCH, 3801 02:14:50,433 --> 02:14:52,402 FUNDED RESEARCHERS WERE WORKING 3802 02:14:52,402 --> 02:14:53,970 ON IDEAS THAT WERE SOMEWHERE ON 3803 02:14:53,970 --> 02:14:54,971 THE ORDER OF SEVEN TO EIGHT 3804 02:14:54,971 --> 02:14:55,571 YEARS OLD. 3805 02:14:55,571 --> 02:14:57,674 AT THE SAME TIME, WE'D SEEN A 3806 02:14:57,674 --> 02:15:02,578 GREYING OF SCIENTIFIC WORKFORCE 3807 02:15:02,578 --> 02:15:04,380 WITH THE AGE OF FIRST LARGE 3808 02:15:04,380 --> 02:15:06,683 GRANT MOVING FROM THE MID 30s 3809 02:15:06,683 --> 02:15:09,352 IN THE 1980s TO SOMEWHERE IN 3810 02:15:09,352 --> 02:15:12,221 THE MID 40s. 3811 02:15:12,221 --> 02:15:18,928 HAVE SVERY SLOW PROGRESSION DESS 3812 02:15:18,928 --> 02:15:20,630 MANY EFFORTS BY THE NIH TO 3813 02:15:20,630 --> 02:15:21,497 REVERSE IT. 3814 02:15:21,497 --> 02:15:24,000 THE PORTFOLIO ITSELF HAS TENDED 3815 02:15:24,000 --> 02:15:25,435 TO EMPHASIZE INCREMENTAL 3816 02:15:25,435 --> 02:15:28,171 ADVANCES THAT ARE VERY LIKELY TO 3817 02:15:28,171 --> 02:15:29,605 SUCCEED, RATHER THAN A PORTFOLIO 3818 02:15:29,605 --> 02:15:32,675 WHERE YOU MAY HAVE FAILURES FOR 3819 02:15:32,675 --> 02:15:33,443 INDIVIDUAL PROJECTS IN THE 3820 02:15:33,443 --> 02:15:34,844 PORTFOLIO BUT THE PORTFOLIO AS A 3821 02:15:34,844 --> 02:15:37,914 WHOLE IS ASKING BIG QUESTIONS SO 3822 02:15:37,914 --> 02:15:41,084 THAT YOU HAVE THE POSSIBILITY OF 3823 02:15:41,084 --> 02:15:43,820 GIANT ADVANCES OF CURES FOR 3824 02:15:43,820 --> 02:15:46,989 DISEASES PREVIOUSLY SEEN AS 3825 02:15:46,989 --> 02:15:48,191 INTRACTABLE, IDEAS FOR 3826 02:15:48,191 --> 02:15:53,896 PREVENTION AND OTHER BOLD IDEAS. 3827 02:15:53,896 --> 02:15:56,399 MY GOAL WILL BE TO TRANSFORM THE 3828 02:15:56,399 --> 02:15:58,601 NIH DECISION-MAKING SO THAT IT 3829 02:15:58,601 --> 02:16:01,471 HAS MORE OF A BIAS TOWARD BOLD 3830 02:16:01,471 --> 02:16:03,439 AND TRANSFORMATIVE IDEAS, NOT 3831 02:16:03,439 --> 02:16:05,842 JUST FOR SOME OF THE MECHANISMS, 3832 02:16:05,842 --> 02:16:07,810 BUT FOR NEARLY EVERY MECHANISM 3833 02:16:07,810 --> 02:16:11,347 THAT WE DO, WE SHOULD BE AIMING 3834 02:16:11,347 --> 02:16:12,982 FOR THE FENCES, WE SHOULD BE 3835 02:16:12,982 --> 02:16:14,517 AIMING FOR HUGE ADVANCES, AND 3836 02:16:14,517 --> 02:16:15,952 THE CRITERIA OF SUCCESS THEN 3837 02:16:15,952 --> 02:16:19,355 WILL BE NOT THAT EVERY SINGLE 3838 02:16:19,355 --> 02:16:21,224 INDIVIDUAL PROJECT CAN SHOW SOME 3839 02:16:21,224 --> 02:16:22,525 SUCCESS IN PUBLISHED PAPERS. 3840 02:16:22,525 --> 02:16:24,394 THAT'S NOT THE KEY QUESTION. 3841 02:16:24,394 --> 02:16:27,130 IF A PORTFOLIO HAS EVERY ELEMENT 3842 02:16:27,130 --> 02:16:28,765 OF IT SUCCEED, THAT PORTFOLIO 3843 02:16:28,765 --> 02:16:31,501 WAS NOT TAKING A SUBSTANTIAL 3844 02:16:31,501 --> 02:16:32,602 ENOUGH RISK AND SWINGING FOR THE 3845 02:16:32,602 --> 02:16:34,570 FENCES ENOUGH TO MAKE BIG 3846 02:16:34,570 --> 02:16:35,037 ADVANCES. 3847 02:16:35,037 --> 02:16:36,205 WHAT WE WANT IS THE PORTFOLIO AS 3848 02:16:36,205 --> 02:16:39,075 A WHOLE TO SUCCEED RATHER THAN 3849 02:16:39,075 --> 02:16:42,779 JUST INDIVIDUAL SINGLE PROJECTS, 3850 02:16:42,779 --> 02:16:44,213 SO THE GOAL WILL BE TO TRANSFORM 3851 02:16:44,213 --> 02:16:46,516 THE NIH TO THINKING IN THIS WAY. 3852 02:16:46,516 --> 02:16:47,917 ARPA-H IS SUPPOSED TO DO THIS, 3853 02:16:47,917 --> 02:16:49,585 OF COURSE, BUT THERE'S NO REASON 3854 02:16:49,585 --> 02:16:51,788 WHY THE NIH ITSELF ALSO SHOULD 3855 02:16:51,788 --> 02:16:58,661 NOT BE DOING THIS. 3856 02:16:58,661 --> 02:17:00,296 FOURTH ITEM. 3857 02:17:00,296 --> 02:17:03,166 THE NIH HAS BEEN AT THE CENTER 3858 02:17:03,166 --> 02:17:06,102 OF THE CONTROVERSY OVER COVID 3859 02:17:06,102 --> 02:17:07,170 ORIGINS. 3860 02:17:07,170 --> 02:17:11,774 THERE ARE MANY RESEARCHERS WHO 3861 02:17:11,774 --> 02:17:13,743 BELIEVE THAT -- AND I RECOGNIZE 3862 02:17:13,743 --> 02:17:15,711 THIS IS A CONTROVERSIAL 3863 02:17:15,711 --> 02:17:18,214 STATEMENT, BUT MANY RESEARCHERS 3864 02:17:18,214 --> 02:17:19,248 BELIEVE IT'S POSSIBLE THAT COVID 3865 02:17:19,248 --> 02:17:22,084 ITSELF WAS THE RESULT OF 3866 02:17:22,084 --> 02:17:22,452 EXPERIMENTATION. 3867 02:17:22,452 --> 02:17:24,053 OF COURSE IN THE DECADE BEFORE 3868 02:17:24,053 --> 02:17:27,323 THE PANDEMIC, THERE WAS MUCH 3869 02:17:27,323 --> 02:17:28,424 CONTROVERSY WITHIN THE 3870 02:17:28,424 --> 02:17:30,159 SCIENTIFIC COMMUNITY OVER THE 3871 02:17:30,159 --> 02:17:31,494 CONDUCT OF GAIN OF FUNCTION 3872 02:17:31,494 --> 02:17:35,865 RESEARCH OF CONCERN WHERE IN 3873 02:17:35,865 --> 02:17:37,266 AGAIN 14, PRESIDENT OBAMA HAD 3874 02:17:37,266 --> 02:17:39,469 ISSUED A PAUSE ON ALL SUCH 3875 02:17:39,469 --> 02:17:40,002 RESEARCH. 3876 02:17:40,002 --> 02:17:40,837 THE REGULATION OF THIS RESEARCH 3877 02:17:40,837 --> 02:17:47,076 IS NOW FRONT AND CENTER OF 3878 02:17:47,076 --> 02:17:47,944 CONGRESSIONAL ACTION. 3879 02:17:47,944 --> 02:17:50,246 AS NIH DIRECTOR, I WANT TO WORK 3880 02:17:50,246 --> 02:17:53,282 TO MAKE SURE THAT THE RESEARCH 3881 02:17:53,282 --> 02:17:55,685 WE SUPPORT DOES NOT POSE ANY 3882 02:17:55,685 --> 02:18:01,858 RISK OR HARM AT ALL TO HUMAN 3883 02:18:01,858 --> 02:18:02,158 POPULATIONS. 3884 02:18:02,158 --> 02:18:08,030 WE SHOULD NOT BE CONDUCTING -- 3885 02:18:08,030 --> 02:18:09,332 IT SHOULD MEET THE HIGHEST 3886 02:18:09,332 --> 02:18:09,899 ETHICAL STANDARD. 3887 02:18:09,899 --> 02:18:11,534 AT THE VERY LEAST, THE PUBLIC 3888 02:18:11,534 --> 02:18:16,572 SHOULD HAVE A SAY ARE THE RISK K 3889 02:18:16,572 --> 02:18:17,874 THAT RESEARCHERS TAKE, SO I'M 3890 02:18:17,874 --> 02:18:19,108 GOING TO MAKE SURE THAT I 3891 02:18:19,108 --> 02:18:19,976 COOPERATE WITH CONGRESSIONAL 3892 02:18:19,976 --> 02:18:21,711 EFFORTS AND EFFORTS BY THE 3893 02:18:21,711 --> 02:18:23,479 ADMINISTRATION TO REGULATE THE 3894 02:18:23,479 --> 02:18:25,214 RESEARCH THAT WE DO TO MEET THE 3895 02:18:25,214 --> 02:18:26,649 HIGHEST ETHICAL STANDARDS, AND 3896 02:18:26,649 --> 02:18:29,051 TO MAKE SURE THAT IT DOES NOT 3897 02:18:29,051 --> 02:18:31,153 ENDANGER HUMAN POPULATIONS IN 3898 02:18:31,153 --> 02:18:39,762 THE CONDUCT OF RESEARCH ITSELF. 3899 02:18:39,762 --> 02:18:42,098 THE NIH MUST FOSTER A CULTURE IN 3900 02:18:42,098 --> 02:18:44,066 WHICH SCIENTISTS CAN EXPRESS 3901 02:18:44,066 --> 02:18:48,437 DISAGREEMENT RESPECTFULLY. 3902 02:18:48,437 --> 02:18:49,739 PLUS EDGE COURAGE ACADEMIC 3903 02:18:49,739 --> 02:18:50,606 FREEDOM. 3904 02:18:50,606 --> 02:18:52,608 I'VE HEARD FROM SEEM INSIDE 3905 02:18:52,608 --> 02:18:53,910 INTRAMURAL RESEARCH, INSIDE NIH 3906 02:18:53,910 --> 02:18:57,179 BOTH DURING THE PANDEMIC AND 3907 02:18:57,179 --> 02:18:58,314 AFTER, THAT THEY OFTEN DON'T 3908 02:18:58,314 --> 02:19:01,150 FEEL THIS WAY. 3909 02:19:01,150 --> 02:19:02,985 THE CULTURE AFTER ACADEMIC 3910 02:19:02,985 --> 02:19:08,124 FREEDOM IN THE SCIENTIFIC 3911 02:19:08,124 --> 02:19:11,994 COMMUNITY I CAN ATTEST 3912 02:19:11,994 --> 02:19:13,629 PERSONALLY -- THE NIH MUST PLAY 3913 02:19:13,629 --> 02:19:15,331 A LEADING ROLE IN ENCOURAGING 3914 02:19:15,331 --> 02:19:15,798 ACADEMIC FREEDOM. 3915 02:19:15,798 --> 02:19:17,833 I'VE BEEN WORKING ON A POLICY TO 3916 02:19:17,833 --> 02:19:19,969 GUARANTEE, FOR INSTANCE, THAT 3917 02:19:19,969 --> 02:19:20,570 INTRAMURAL RESEARCHERS IN THE 3918 02:19:20,570 --> 02:19:23,940 NIH WILL HAVE MINIMAL OVERSIGHT 3919 02:19:23,940 --> 02:19:25,141 OVER WHETHER THEIR SCIENTIFIC 3920 02:19:25,141 --> 02:19:26,475 RESEARCH CAN BE PUBLISHED. 3921 02:19:26,475 --> 02:19:28,344 ONLY SUBJECT TO FEDERAL 3922 02:19:28,344 --> 02:19:31,414 REGULATIONS OR LAWS, BUT NO 3923 02:19:31,414 --> 02:19:32,848 SUBSTANTIVE OVERSIGHT, SO THAT 3924 02:19:32,848 --> 02:19:34,183 RESEARCHERS WHO FIND RESEARCH 3925 02:19:34,183 --> 02:19:35,585 RESULTS THAT, FOR INSTANCE, I 3926 02:19:35,585 --> 02:19:36,786 DON'T LIKE SHOULD HAVE THE 3927 02:19:36,786 --> 02:19:38,521 ABSOLUTE RIGHT TO PUBLISH IT 3928 02:19:38,521 --> 02:19:40,723 WITHOUT ANY SAY-SO ON MY PART. 3929 02:19:40,723 --> 02:19:42,725 THE KIND OF ACADEMIC FREEDOM 3930 02:19:42,725 --> 02:19:44,460 THAT I THOUGHT WE ENJOYED AS 3931 02:19:44,460 --> 02:19:46,862 RESEARCHERS BEFORE THE PANDEMIC 3932 02:19:46,862 --> 02:19:50,032 IS THE KIND OF ACADEMIC FREEDOM 3933 02:19:50,032 --> 02:19:52,134 THAT SAYS YOU CAN FIND WHATEVER 3934 02:19:52,134 --> 02:19:53,436 RESULT YOU LIKE, YOU CAN HAVE 3935 02:19:53,436 --> 02:19:54,870 WHATEVER DISCUSSION YOU LIKE AS 3936 02:19:54,870 --> 02:19:56,539 A RESEARCHER, THAT IS YOUR 3937 02:19:56,539 --> 02:19:59,241 ABSOLUTE RIGHT TO DO SO. 3938 02:19:59,241 --> 02:20:00,676 SCIENTIFIC PROGRESS DEPENDS ON 3939 02:20:00,676 --> 02:20:03,312 THE RIGHT FOR RESEARCHERS TO 3940 02:20:03,312 --> 02:20:04,413 DISSENT AGAINST SCIENTIFIC 3941 02:20:04,413 --> 02:20:05,081 DOGMAS. 3942 02:20:05,081 --> 02:20:06,482 AND THE NIH WILL WORK TO MAKE 3943 02:20:06,482 --> 02:20:09,685 SURE THAT INTRAMURAL RESEARCHERS 3944 02:20:09,685 --> 02:20:11,087 HAVE THIS KIND OF ACADEMIC 3945 02:20:11,087 --> 02:20:12,188 FREEDOM, AND THAT WE ENCOURAGE 3946 02:20:12,188 --> 02:20:14,056 THE SAME KIND OF ACADEMIC 3947 02:20:14,056 --> 02:20:15,358 FREEDOM IN THE EXTRAMURAL 3948 02:20:15,358 --> 02:20:21,931 SCIENTIFIC COMMUNITY. 3949 02:20:21,931 --> 02:20:23,366 NOVEL BIOMEDICAL DISCOVERIES 3950 02:20:23,366 --> 02:20:24,800 THAT ENHANCE HEALTH AND LENGTHEN 3951 02:20:24,800 --> 02:20:27,203 LIFE ARE MORE VITAL THAN EVER TO 3952 02:20:27,203 --> 02:20:28,204 OUR COUNTRY'S FUTURE. 3953 02:20:28,204 --> 02:20:29,205 BUT THAT, OF COURSE, IS THE 3954 02:20:29,205 --> 02:20:29,839 MISSION OF THE NIH. 3955 02:20:29,839 --> 02:20:33,576 I'M GOING TO END NOW AND LEAVE 3956 02:20:33,576 --> 02:20:34,877 TIME, A FEW MINUTES FOR 3957 02:20:34,877 --> 02:20:35,211 QUESTIONS. 3958 02:20:35,211 --> 02:20:39,749 FINAL SLIDE. 3959 02:20:39,749 --> 02:20:41,584 >> THANK YOU SO MUCH, JAY. 3960 02:20:41,584 --> 02:20:43,986 SO WE WILL NOW OPEN THE FLOOR TO 3961 02:20:43,986 --> 02:20:54,497 COUNCILMEMBERS FOR QUESTIONS. 3962 02:20:55,131 --> 02:20:56,599 MONICA, PLEASE GO AHEAD. 3963 02:20:56,599 --> 02:20:59,001 >> JAY, THAT WAS A GREAT TALK, 3964 02:20:59,001 --> 02:21:02,538 AND I WANTED TO SAY THAT I THINK 3965 02:21:02,538 --> 02:21:06,242 YOU ENTERED AT A DIFFICULT TIME, 3966 02:21:06,242 --> 02:21:08,077 BECAUSE OF CHANGES THAT OCCURRED 3967 02:21:08,077 --> 02:21:11,614 BEFORE YOU CAME BETWEEN THE 3968 02:21:11,614 --> 02:21:13,916 ELECTION AND WHEN YOU ENTERED. 3969 02:21:13,916 --> 02:21:18,621 AND I WANTED TO ASK ABOUT YOUR 3970 02:21:18,621 --> 02:21:19,655 ABILITY, I THINK YOU'VE BEEN 3971 02:21:19,655 --> 02:21:22,491 DOING A GREAT JOB IN INTRAMURAL 3972 02:21:22,491 --> 02:21:25,428 AND EXTRAMURAL TRYING TO ALLAY 3973 02:21:25,428 --> 02:21:27,530 SOME OF THE ANXIETIES THAT WERE 3974 02:21:27,530 --> 02:21:30,032 CAUSED BY, FOR EXAMPLE, GRANT 3975 02:21:30,032 --> 02:21:32,034 TERMINATIONS, GRANTS NOT GOING 3976 02:21:32,034 --> 02:21:34,003 OUT, NOFOs, LOTS OF THINGS 3977 02:21:34,003 --> 02:21:37,206 THAT WERE REALLY DIFFERENT FOR 3978 02:21:37,206 --> 02:21:38,407 THE NIH THAN HAD HAPPENED 3979 02:21:38,407 --> 02:21:38,708 BEFORE. 3980 02:21:38,708 --> 02:21:40,242 I THINK YOU'VE BEEN REALLY 3981 02:21:40,242 --> 02:21:41,677 TRYING YOUR BEST, YOU'VE ONLY 3982 02:21:41,677 --> 02:21:44,647 BEEN THERE SINCE APRIL 1ST, TO 3983 02:21:44,647 --> 02:21:46,282 DO WHAT YOU CAN TO ALLAY SOME OF 3984 02:21:46,282 --> 02:21:48,050 THOSE ANXIETYS THAT PEOPLE HAVE. 3985 02:21:48,050 --> 02:21:50,019 I THINK THAT, LIKE YOU SAID, 3986 02:21:50,019 --> 02:21:52,755 SCIENCE WILL CHANGE, BUT IT WAS 3987 02:21:52,755 --> 02:21:58,360 THE RAPID PACE AND ALSO AT TIMES 3988 02:21:58,360 --> 02:21:59,562 HAVING ADJUDICATION OF GRANTS 3989 02:21:59,562 --> 02:22:02,098 AND TERMINATIONS NOT BY 3990 02:22:02,098 --> 02:22:03,299 SCIENTISTS CREATED A LOT OF 3991 02:22:03,299 --> 02:22:04,867 ANXIETY. 3992 02:22:04,867 --> 02:22:09,004 MY QUESTION IS ACTUALLY AROUND 3993 02:22:09,004 --> 02:22:13,042 THE PROPOSED NIH BUDGET PASS 3994 02:22:13,042 --> 02:22:18,647 BACK CUTS IN THE PASS BACK --S 3995 02:22:18,647 --> 02:22:20,750 THAT ALMOST LEAKED LAST WEEK BUT 3996 02:22:20,750 --> 02:22:22,151 YOUR ABILITY AND YOUR PRESENCE 3997 02:22:22,151 --> 02:22:27,623 IN CONGRESS AND YOU -- WILL YOU 3998 02:22:27,623 --> 02:22:29,859 BE ABLE TO BE A PART OF THOSE 3999 02:22:29,859 --> 02:22:32,795 DISCUSSIONS WITH CONGRESS AS THE 4000 02:22:32,795 --> 02:22:33,796 NIH DIRECTOR WHEN THOSE COME UP 4001 02:22:33,796 --> 02:22:35,331 WITH THE ULTIMATE BUDGET OF THE 4002 02:22:35,331 --> 02:22:37,633 NIH GOING IN STARTING FROM JUNE 4003 02:22:37,633 --> 02:22:39,235 OF THIS YEAR, WHAT'S GOING TO BE 4004 02:22:39,235 --> 02:22:40,302 PROPOSED FOR THE BUDGET, WILL 4005 02:22:40,302 --> 02:22:44,039 YOU BE ABLE TO BE, AS YOU SAID, 4006 02:22:44,039 --> 02:22:45,374 IN FRONT OF CONGRESS LIKE YOU 4007 02:22:45,374 --> 02:22:52,381 JUST SAID? 4008 02:22:52,381 --> 02:22:53,649 >> CAN'T HEAR. 4009 02:22:53,649 --> 02:22:54,450 >> NOW WE CAN. 4010 02:22:54,450 --> 02:22:59,288 >> JAY, YOU'RE STILL ON MUTE. 4011 02:22:59,288 --> 02:23:00,055 >> OKAY. 4012 02:23:00,055 --> 02:23:01,223 CAN YOU HEAR ME NOW? 4013 02:23:01,223 --> 02:23:01,957 >> YES. 4014 02:23:01,957 --> 02:23:03,292 >> OKAY. 4015 02:23:03,292 --> 02:23:04,160 MONICA, THANK YOU FOR THAT. 4016 02:23:04,160 --> 02:23:05,928 IT HAS -- AS YOU SAY, IT HAS 4017 02:23:05,928 --> 02:23:07,797 BEEN A CHALLENGING TIME. 4018 02:23:07,797 --> 02:23:09,765 AND A LOT OF CHANGES HAVE TAKEN 4019 02:23:09,765 --> 02:23:10,199 PLACE. 4020 02:23:10,199 --> 02:23:12,268 SOME FOR THE BETTER, SOME FOR 4021 02:23:12,268 --> 02:23:13,135 THE WORSE FOR SURE. 4022 02:23:13,135 --> 02:23:14,537 I'VE BEEN TRYING MY ABSOLUTE 4023 02:23:14,537 --> 02:23:16,272 BEST TO TURN THE LIGHT SWITCHES 4024 02:23:16,272 --> 02:23:16,839 BACK ON. 4025 02:23:16,839 --> 02:23:21,310 SO FOR INSTANCE, THE DISRUPTION 4026 02:23:21,310 --> 02:23:24,513 IN THE SCIENTIFIC REVIEW PANELS, 4027 02:23:24,513 --> 02:23:27,049 WE HAVE RESOLVED I THINK BY MAY, 4028 02:23:27,049 --> 02:23:28,417 WE SHOULD HAVE -- WE SHOULD BE 4029 02:23:28,417 --> 02:23:31,453 NO LONGER BEHIND. 4030 02:23:31,453 --> 02:23:34,390 WE'VE MADE IT SO THE INTRAMURAL 4031 02:23:34,390 --> 02:23:36,358 RESEARCHERS CAN ORDER THEIR 4032 02:23:36,358 --> 02:23:39,094 SUPPLIES FOR THEIR LABS, WE'VE 4033 02:23:39,094 --> 02:23:41,397 TURNED ON TRAVEL. 4034 02:23:41,397 --> 02:23:42,965 I WANT SCIENCE TO CONTINUE IN 4035 02:23:42,965 --> 02:23:43,966 THIS COUNTRY LIKE IT'S SUPPOSED 4036 02:23:43,966 --> 02:23:46,035 TO, AND I'M WORKING VERY, VERY 4037 02:23:46,035 --> 02:23:47,469 HARD TO UNDO SOME OF THE 4038 02:23:47,469 --> 02:23:48,604 DISRUPTIONS THAT HAPPENED. 4039 02:23:48,604 --> 02:23:52,975 I THINK IN PART BECAUSE OF 4040 02:23:52,975 --> 02:23:54,076 MISUNDERSTANDINGS AND ALSO 4041 02:23:54,076 --> 02:23:57,012 ANXIETY OVER THE POLITICAL 4042 02:23:57,012 --> 02:23:58,147 CHANGES, A LOT OF IT HAS TO DO 4043 02:23:58,147 --> 02:23:58,914 WITH THAT. 4044 02:23:58,914 --> 02:24:00,549 AND I'VE BEEN TRYING VERY, VERY 4045 02:24:00,549 --> 02:24:02,785 HARD TO TURN THOSE BACK ON. 4046 02:24:02,785 --> 02:24:05,321 THE BUSINESS OF SCIENCE AND 4047 02:24:05,321 --> 02:24:06,155 BIOMEDICAL SCIENCE ABSOLUTELY 4048 02:24:06,155 --> 02:24:07,623 NEEDS TO CONTINUE, IT'S AN 4049 02:24:07,623 --> 02:24:08,457 ABSOLUTE PRIORITY OF MINE TO 4050 02:24:08,457 --> 02:24:10,826 THATMAKE THAT HAPPEN, MONICA. 4051 02:24:10,826 --> 02:24:12,995 AS FAR AS THE BUDGET PASS BACKS, 4052 02:24:12,995 --> 02:24:15,865 I CAN'T COMMENT SPECIFICALLY ON 4053 02:24:15,865 --> 02:24:16,332 THE LEAK. 4054 02:24:16,332 --> 02:24:18,500 NORMALLY THIS IS A PROCESS THAT 4055 02:24:18,500 --> 02:24:21,337 IS A NEGOTIATION BETWEEN THE OMB 4056 02:24:21,337 --> 02:24:23,138 AND THE AGENCIES, INCLUDING 4057 02:24:23,138 --> 02:24:24,673 MY -- INCLUDING THE NIH. 4058 02:24:24,673 --> 02:24:26,976 I SHOULD SAY JUST AS A BROAD 4059 02:24:26,976 --> 02:24:28,444 MATTER, I'VE SPOKEN TO MANY, 4060 02:24:28,444 --> 02:24:30,279 MANY MEMBERS OF CONGRESS IN THE 4061 02:24:30,279 --> 02:24:33,582 CONTEXT OF MY CONFIRMATION, AND 4062 02:24:33,582 --> 02:24:34,683 I'VE HEARD BIPARTISAN SUPPORT 4063 02:24:34,683 --> 02:24:37,319 FOR THE NIH CONTINUING. 4064 02:24:37,319 --> 02:24:39,955 AND I'VE ALSO HEARD -- I'VE SEEN 4065 02:24:39,955 --> 02:24:40,589 THAT PRESIDENT TRUMP WROTE A 4066 02:24:40,589 --> 02:24:45,194 LETTER TO THE INCOMING OSDP 4067 02:24:45,194 --> 02:24:45,995 DIRECTOR WITH HIS COMMITMENT 4068 02:24:45,995 --> 02:24:48,063 THAT THE UNITED STATES LEAD THE 4069 02:24:48,063 --> 02:24:50,032 WORLD IN BIOMEDICINE IN THE 21ST 4070 02:24:50,032 --> 02:24:50,833 CENTURY. 4071 02:24:50,833 --> 02:24:52,468 AND I WILL ADVOCATE TO MAKE SURE 4072 02:24:52,468 --> 02:24:53,869 THAT THE NIH HAS THE CAPACITY 4073 02:24:53,869 --> 02:24:55,804 AND THE RESOURCES TO DO THAT. 4074 02:24:55,804 --> 02:25:00,609 >> THANK YOU. 4075 02:25:00,609 --> 02:25:03,979 >> THANKS VERY MUCH. 4076 02:25:03,979 --> 02:25:05,648 KEVIN, DR. JOHNSON, GO AHEAD. 4077 02:25:05,648 --> 02:25:08,050 >> YES, HELLO. 4078 02:25:08,050 --> 02:25:08,717 DR. BHATTACHARYA, VERY NICE TO 4079 02:25:08,717 --> 02:25:10,252 MEET YOU. 4080 02:25:10,252 --> 02:25:12,087 I'M CURIOUS ABOUT -- I LOVE MUCH 4081 02:25:12,087 --> 02:25:14,089 OF WHAT YOU SAID IN TERMS OF 4082 02:25:14,089 --> 02:25:16,725 SOME OF THE REALLY DISRUPTIVE 4083 02:25:16,725 --> 02:25:18,694 APPROACHES TO KIND OF GETTING 4084 02:25:18,694 --> 02:25:21,697 BIG IDEAS FUNDED, GENERATED AND 4085 02:25:21,697 --> 02:25:23,332 SUPPORTED AS WELL AS THE IDEA OF 4086 02:25:23,332 --> 02:25:24,733 A JOURNAL FOR HELPING WITH 4087 02:25:24,733 --> 02:25:26,001 REPLICATION OF STUDIES. 4088 02:25:26,001 --> 02:25:27,536 ONE THING THAT I DIDN'T HEAR YOU 4089 02:25:27,536 --> 02:25:28,837 TALK MUCH ABOUT IS THE TRAINING 4090 02:25:28,837 --> 02:25:30,205 PROGRAM, AND I WAS WONDERING IF 4091 02:25:30,205 --> 02:25:32,374 YOU COULD JUST TALK ABOUT YOUR 4092 02:25:32,374 --> 02:25:35,010 VIEW OF HOW THE NIH SHOULD BE 4093 02:25:35,010 --> 02:25:38,180 INVOLVED IN TRAINING PEOPLE. 4094 02:25:38,180 --> 02:25:39,515 ESPECIALLY GIVEN THIS POTENTIAL 4095 02:25:39,515 --> 02:25:41,917 FOCUS ON BIG IDEAS AT A TIME 4096 02:25:41,917 --> 02:25:43,652 WHEN TRAINEES GETTING THEIR 4097 02:25:43,652 --> 02:25:44,753 FIRST GRANTS PROBABLY WON'T COME 4098 02:25:44,753 --> 02:25:48,424 UP WITH BIG IDEAS. 4099 02:25:48,424 --> 02:25:49,825 >> THANK YOU, DR. JOHNSON. 4100 02:25:49,825 --> 02:25:52,227 I APPRECIATE THE QUESTION. 4101 02:25:52,227 --> 02:25:57,833 I ABSOLUTELY THINK -- 4102 02:25:57,833 --> 02:25:58,133 [INAUDIBLE] 4103 02:25:58,133 --> 02:25:59,468 >> CAN'T HEAR VERY WELL. 4104 02:25:59,468 --> 02:26:00,336 >> WE CAN'T HEAR YOU. 4105 02:26:00,336 --> 02:26:02,571 >> YOUR VOLUME HAS GONE DOWN 4106 02:26:02,571 --> 02:26:03,038 AGAIN. 4107 02:26:03,038 --> 02:26:04,573 >> I DON'T KNOW WHAT I'M DOING 4108 02:26:04,573 --> 02:26:05,307 WRONG, YOU GUYS. 4109 02:26:05,307 --> 02:26:05,741 SORRY. 4110 02:26:05,741 --> 02:26:07,743 HOPHOPEFULLY YOU CAN HEAR ME NO. 4111 02:26:07,743 --> 02:26:08,177 >> YES. 4112 02:26:08,177 --> 02:26:08,744 >> OKAY. 4113 02:26:08,744 --> 02:26:10,512 I GUESS I JUST NEED TO LEAN 4114 02:26:10,512 --> 02:26:11,180 FORWARD. 4115 02:26:11,180 --> 02:26:11,947 DR. JOHNSON, THANK YOU FOR THAT 4116 02:26:11,947 --> 02:26:12,214 QUESTION. 4117 02:26:12,214 --> 02:26:15,117 IT IS ABSOLUTELY VITAL THAT OUR 4118 02:26:15,117 --> 02:26:17,019 TRAINING PROGRAMS TRAIN THE NEXT 4119 02:26:17,019 --> 02:26:19,855 GENERATION OF SCIENTISTS AND 4120 02:26:19,855 --> 02:26:21,623 ENABLE THEM TO TRY THEIR IDEAS 4121 02:26:21,623 --> 02:26:22,157 OUT. 4122 02:26:22,157 --> 02:26:24,259 I'VE DONE SOME RESEARCH AGAIN 4123 02:26:24,259 --> 02:26:29,298 BEFORE THE PANDEMIC ASKING 4124 02:26:29,298 --> 02:26:30,399 WHETHER IT WAS EARLY CAREER 4125 02:26:30,399 --> 02:26:31,700 SCIENTISTS OR LATER CAREER 4126 02:26:31,700 --> 02:26:32,935 SCIENTISTS WHO WERE MORE LIKELY 4127 02:26:32,935 --> 02:26:36,105 TO TRY OUT IDEAS ON THE CUTTING 4128 02:26:36,105 --> 02:26:37,539 EDGE IN THEIR OWN PUBLISHED 4129 02:26:37,539 --> 02:26:40,609 WORK. 4130 02:26:40,609 --> 02:26:46,015 THE FACT, SLIGHTLY -- WITH GREY 4131 02:26:46,015 --> 02:26:47,649 HAIR LIKE ME IS THAT IT'S EARLY 4132 02:26:47,649 --> 02:26:48,851 CAREER SCIENTISTS WHO TEND TO 4133 02:26:48,851 --> 02:26:50,652 WORK ON THE NEWER IDEAS, WHO 4134 02:26:50,652 --> 02:26:51,086 WORK ON THE EDGE. 4135 02:26:51,086 --> 02:26:53,489 IN FACT, IT'S EARLY CAREER 4136 02:26:53,489 --> 02:26:54,690 SCIENTISTS, WOULDING WITH MID 4137 02:26:54,690 --> 02:26:55,491 CAREER SCIENTISTS TOGETHER THAT 4138 02:26:55,491 --> 02:26:57,026 ARE THE GROUP THAT ARE MOST 4139 02:26:57,026 --> 02:26:58,327 LIKELY TO TRY OUT IN IDEAS. 4140 02:26:58,327 --> 02:27:02,531 NEW IDEAS.SO FOR ME, IT IS ABSOY 4141 02:27:02,531 --> 02:27:03,832 VITAL THAT WE ENABLE EARLY 4142 02:27:03,832 --> 02:27:05,601 CAREER SCIENTISTS TO PROGRESS 4143 02:27:05,601 --> 02:27:06,668 INTO INDEPENDENCE AS RAPIDLY AS 4144 02:27:06,668 --> 02:27:08,570 THEY CAN. 4145 02:27:08,570 --> 02:27:09,905 WHILE STILL MAINTAINING SORT OF 4146 02:27:09,905 --> 02:27:13,442 THE WISDOM AND OVERSIGHT OF 4147 02:27:13,442 --> 02:27:15,044 LATER CAREER SCIENTISTS IN 4148 02:27:15,044 --> 02:27:18,547 COLLABORATION. 4149 02:27:18,547 --> 02:27:19,982 TO DO THIS, I'M NOT SURE EXACTLY 4150 02:27:19,982 --> 02:27:25,154 HOW TO AB PUBLISH PUBLISH THIS, 4151 02:27:25,154 --> 02:27:26,255 DR. JOHNSON, BUT SOME OF THE 4152 02:27:26,255 --> 02:27:28,057 IDEAS -- AT THIS POINT I'M NOT 4153 02:27:28,057 --> 02:27:30,993 SURE THIS IS -- IF ANY OF THIS 4154 02:27:30,993 --> 02:27:33,195 IS READY FOR PRIME TIME BUT I'LL 4155 02:27:33,195 --> 02:27:34,263 JUST TELL YOU WHAT I'VE BEEN 4156 02:27:34,263 --> 02:27:35,230 THINKING. 4157 02:27:35,230 --> 02:27:37,733 EVALUATING RESEARCH PROJECTS ON 4158 02:27:37,733 --> 02:27:43,672 THE ADVANCE OF POSTDOCS IN 4159 02:27:43,672 --> 02:27:46,008 INDEPENDENCE, HAVING Ks BE 4160 02:27:46,008 --> 02:27:47,309 INSTITUTED, HAVING MORE 4161 02:27:47,309 --> 02:27:50,813 INSTITUTIONAL K AWARDS RATHER 4162 02:27:50,813 --> 02:27:52,981 THAN THE INDIVIDUAL SO WHEN AN 4163 02:27:52,981 --> 02:27:54,550 EARLY CAREER INVESTIGATOR IS 4164 02:27:54,550 --> 02:27:55,884 HIRED AT AN INSTITUTION, THEY 4165 02:27:55,884 --> 02:27:58,654 CAN JUST HAVE THE RESEARCHER GET 4166 02:27:58,654 --> 02:27:59,655 THE EARLY CAREER SUPPORT 4167 02:27:59,655 --> 02:28:01,824 IMMEDIATELY RATHER THAN HAVING 4168 02:28:01,824 --> 02:28:03,592 TO GO THROUGH A LONG K 4169 02:28:03,592 --> 02:28:06,328 APPLICATION WHICH SOMETIMES 4170 02:28:06,328 --> 02:28:08,897 TAKES YEARS, ALLOWING 4171 02:28:08,897 --> 02:28:12,000 RESEARCHING THAT HAVE TRAINING 4172 02:28:12,000 --> 02:28:14,903 SUPPORT TO APPLY FOR R LEVEL 4173 02:28:14,903 --> 02:28:15,804 FUNDING RATHER THAN MAKING THAT 4174 02:28:15,804 --> 02:28:16,271 A RESTRICTION. 4175 02:28:16,271 --> 02:28:19,241 I'M HOPING FOR LOTS AND LOTS OF 4176 02:28:19,241 --> 02:28:20,008 IDEAS FOR THIS. 4177 02:28:20,008 --> 02:28:21,577 THINK IT'S ABSOLUTELY ESSENTIAL 4178 02:28:21,577 --> 02:28:22,578 FOR THE FUTURE OF BIOMEDICINE 4179 02:28:22,578 --> 02:28:28,917 THAT WE UNLEASH THE IDEAS OF THE 4180 02:28:28,917 --> 02:28:30,352 EARLY CAREER SCIENTISTS. 4181 02:28:30,352 --> 02:28:32,387 I FULLY EXPECT MOST OF MY IDEAS 4182 02:28:32,387 --> 02:28:34,790 TO BE COMPLETELY OVERTURNED, IF 4183 02:28:34,790 --> 02:28:35,958 NOT, THEN WE HAVEN'T DONE A GOOD 4184 02:28:35,958 --> 02:28:39,027 ENOUGH JOB. 4185 02:28:39,027 --> 02:28:40,429 >> OKAY, GREAT. 4186 02:28:40,429 --> 02:28:46,568 RAFAEL IS NEXT. 4187 02:28:46,568 --> 02:28:48,170 >> HI, THANKS. 4188 02:28:48,170 --> 02:28:49,004 CONGRATULATIONS ON YOUR 4189 02:28:49,004 --> 02:28:49,671 APPOINTMENT AND THANK YOU FOR 4190 02:28:49,671 --> 02:28:55,010 YOUR THOUGHTFUL REMARKS. 4191 02:28:55,010 --> 02:28:56,345 I WAS PARTICULARLY PLEASED TO 4192 02:28:56,345 --> 02:28:58,413 HEAR THAT REPRODUCIBLE RESEARCH 4193 02:28:58,413 --> 02:28:59,715 IS A PRIORITY. 4194 02:28:59,715 --> 02:29:01,183 THAT'S AN AREA I THINK DEEPLY 4195 02:29:01,183 --> 02:29:02,718 ABOUT AND IT'S ONE OF THE 4196 02:29:02,718 --> 02:29:05,287 MISSIONS OF MY ROLE AS CHAIR, IS 4197 02:29:05,287 --> 02:29:06,555 TO MAKE THAT BETTER AT MY 4198 02:29:06,555 --> 02:29:07,055 INSTITUTION. 4199 02:29:07,055 --> 02:29:10,459 SO I WANT TO EXPRESS MY FULL 4200 02:29:10,459 --> 02:29:13,562 SUPPORT AND HELP TO ADVANCE THAT 4201 02:29:13,562 --> 02:29:14,429 ROLE IN THE COUNCIL. 4202 02:29:14,429 --> 02:29:16,632 I ALSO WAS ENCOURAGED BY YOUR 4203 02:29:16,632 --> 02:29:17,866 WORDS ON ACADEMIC FREEDOM. 4204 02:29:17,866 --> 02:29:20,269 SUPER IMPORTANT. 4205 02:29:20,269 --> 02:29:21,703 SO I'M ALSO ENCOURAGED TO HEAR 4206 02:29:21,703 --> 02:29:23,172 THE CONTINUED COMMITMENT TO THE 4207 02:29:23,172 --> 02:29:25,340 IMPORTANCE OF FUNDING, AND I'M 4208 02:29:25,340 --> 02:29:26,408 CONFIDENT THAT THIS REMAINS ONE 4209 02:29:26,408 --> 02:29:27,976 OF THE MOST VALUABLE INVESTMENTS 4210 02:29:27,976 --> 02:29:31,647 WE MAKE AS TAXPAYERS. 4211 02:29:31,647 --> 02:29:32,848 SO NOW WHILE INCREASED SUPPORT 4212 02:29:32,848 --> 02:29:34,583 AND INVESTMENT IS, OF COURSE, 4213 02:29:34,583 --> 02:29:36,051 WELCOMED BY SCIENTISTS, I ALSO 4214 02:29:36,051 --> 02:29:38,854 WANT TO EXPRESS MY CONFIDENCE IN 4215 02:29:38,854 --> 02:29:40,422 THE RESILIENCE AND CREATIVITY OF 4216 02:29:40,422 --> 02:29:42,658 OUR CURRENT WORKFORCE TO ADOPT 4217 02:29:42,658 --> 02:29:44,526 AND MAKE MEANINGFUL USE OF 4218 02:29:44,526 --> 02:29:45,961 AVAILABLE RESOURCES EVEN IF THEY 4219 02:29:45,961 --> 02:29:49,231 ARE REDUCED. 4220 02:29:49,231 --> 02:29:51,667 SO WITH THAT ALL SAID, I WANT TO 4221 02:29:51,667 --> 02:29:53,769 SHARE ONE CONCERN I HOPE YOU CAN 4222 02:29:53,769 --> 02:29:54,736 HELP WITH AND MAYBE YOU CAN 4223 02:29:54,736 --> 02:29:55,771 SHARE YOUR THOUGHTS ON THE TOPIC 4224 02:29:55,771 --> 02:29:57,539 AND IT HAS TO DO WITH THE 4225 02:29:57,539 --> 02:29:58,273 CURRENT UNCERTAINTY. 4226 02:29:58,273 --> 02:30:00,742 MONICA MADE SOME REMARKS ABOUT 4227 02:30:00,742 --> 02:30:02,377 THAT, AROUND FUNDING LEVELS AND 4228 02:30:02,377 --> 02:30:03,679 AREAS OF RESEARCH THAT WILL NO 4229 02:30:03,679 --> 02:30:07,349 LONGER BE SUPPORTED, ALSO 4230 02:30:07,349 --> 02:30:08,083 INSTITUTIONAL ELIGIBILITY TO 4231 02:30:08,083 --> 02:30:08,650 THESE FUNDS. 4232 02:30:08,650 --> 02:30:10,619 SO THIS UNCERTAINTY MAKES IT 4233 02:30:10,619 --> 02:30:12,854 DIFFICULT TO PLAN STRATEGICALLY, 4234 02:30:12,854 --> 02:30:14,189 WHETHER IT IS HIRING OR 4235 02:30:14,189 --> 02:30:15,290 COLLABORATIONS OR LONG TERM 4236 02:30:15,290 --> 02:30:17,125 RESEARCH COMMITMENTS, SO ANY 4237 02:30:17,125 --> 02:30:19,294 CLEARER GUIDANCE YOU CAN GET 4238 02:30:19,294 --> 02:30:21,997 FROM THE NIH, I THINK COULD BE 4239 02:30:21,997 --> 02:30:22,764 VERY HELPFUL. 4240 02:30:22,764 --> 02:30:24,499 SO THANK YOU AGAIN FOR YOUR 4241 02:30:24,499 --> 02:30:25,534 LEADERSHIP AND FOR TAKING THE 4242 02:30:25,534 --> 02:30:26,435 TIME TO ENGAGE WITH COUNCIL. 4243 02:30:26,435 --> 02:30:28,070 I LOOK FORWARD TO SUPPORTING 4244 02:30:28,070 --> 02:30:29,171 YOUR EFFORTS HOWEVER I CAN AND 4245 02:30:29,171 --> 02:30:30,606 TO HEARING YOUR ANSWERS TO THESE 4246 02:30:30,606 --> 02:30:31,406 QUESTIONS. 4247 02:30:31,406 --> 02:30:33,942 THANK YOU. 4248 02:30:33,942 --> 02:30:36,645 >> RAFAEL, THANK YOU FOR THAT. 4249 02:30:36,645 --> 02:30:38,780 AS I SAID, I COME FROM ACADEMICS 4250 02:30:38,780 --> 02:30:40,115 MYSELF, SO I UNDERSTAND ENTIRELY 4251 02:30:40,115 --> 02:30:41,850 WHAT YOU MEAN ABOUT THE 4252 02:30:41,850 --> 02:30:43,051 UNCERTAINTY. 4253 02:30:43,051 --> 02:30:45,921 THIS IS THE MAIN REASON I WANT 4254 02:30:45,921 --> 02:30:48,457 TO START PUSHING AS HARD AS I 4255 02:30:48,457 --> 02:30:50,425 CAN TO RESTORE REGULAR ORDER. 4256 02:30:50,425 --> 02:30:52,327 EVEN IF WE ARE CHANGING AND 4257 02:30:52,327 --> 02:30:55,330 SHIFTING SOME RESEARCH EMPHASES 4258 02:30:55,330 --> 02:30:56,498 TOWARDS THIS MAKE AMERICA 4259 02:30:56,498 --> 02:30:57,432 HEALTHY, AS LONG AS YOU CAN PLAN 4260 02:30:57,432 --> 02:31:00,168 AROUND IT, YOU CAN DEVOTE YOUR 4261 02:31:00,168 --> 02:31:03,872 TIME AND EFFORTS TO IT. 4262 02:31:03,872 --> 02:31:06,708 SO I MEAN, I THINK THERE'S BEEN, 4263 02:31:06,708 --> 02:31:08,543 I THINK, TWO CLASSES OF 4264 02:31:08,543 --> 02:31:08,877 DISRUPTIONS. 4265 02:31:08,877 --> 02:31:13,248 ONE, I THINK HEALTHY AND ONE 4266 02:31:13,248 --> 02:31:13,915 LESS HEALTHY. 4267 02:31:13,915 --> 02:31:19,755 ONE IS THE EMPHASIS ON MAKE 4268 02:31:19,755 --> 02:31:24,960 AMERICA HMAKEAMERICA HEALTHY ANY 4269 02:31:24,960 --> 02:31:26,695 TOWARDS POLITICIZED IDEAS 4270 02:31:26,695 --> 02:31:27,195 TOWARDS RESEARCH THAT IS 4271 02:31:27,195 --> 02:31:28,096 DIRECTLY AIMED AT THE MELT 4272 02:31:28,096 --> 02:31:31,266 HEALTH FLEEDZ NEEDS OF THE AMERN 4273 02:31:31,266 --> 02:31:33,101 PEOPLE, I THINK THAT'S A HEALTHY 4274 02:31:33,101 --> 02:31:33,635 THING. 4275 02:31:33,635 --> 02:31:34,636 THAT'S AUTOMATICALLY GOING TO 4276 02:31:34,636 --> 02:31:35,837 CAUSE SOME DISRUPTIONS BECAUSE 4277 02:31:35,837 --> 02:31:37,005 THE KINDS OF RESEARCH PROJECTS 4278 02:31:37,005 --> 02:31:38,273 THAT SORT OF ARE, FOR INSTANCE, 4279 02:31:38,273 --> 02:31:41,109 FOLLOW A STYLE OF THE 4280 02:31:41,109 --> 02:31:43,779 PRESIDENT'S EXECUTIVE ORDERS, 4281 02:31:43,779 --> 02:31:45,314 YOU'RE GOING TO HAVE LESS OF 4282 02:31:45,314 --> 02:31:46,415 THAT, BUT AT THE SAME TIME, THE 4283 02:31:46,415 --> 02:31:47,716 COMMITMENT TO MAKE SURE THAT 4284 02:31:47,716 --> 02:31:49,484 EVERY SINGLE AMERICAN, NO MATTER 4285 02:31:49,484 --> 02:31:52,921 WHAT THEIR RACE, SEX, YOU KNOW, 4286 02:31:52,921 --> 02:31:55,223 THEIR SEXUAL ORIENTATION OR 4287 02:31:55,223 --> 02:31:56,858 WHATNOT, THAT THEIR HEALTH NEEDS 4288 02:31:56,858 --> 02:31:58,727 ARE REFLECTED IN THE PORTFOLIO 4289 02:31:58,727 --> 02:32:01,396 OF THE NIH, I REMAIN ENTIRELY 4290 02:32:01,396 --> 02:32:01,963 COMMITTED TO THAT. 4291 02:32:01,963 --> 02:32:04,633 AND SO I THINK THAT IS GOING TO 4292 02:32:04,633 --> 02:32:06,268 BE ULTIMATELY A HEALTHY 4293 02:32:06,268 --> 02:32:08,670 TRANSITION SO THAT THE 4294 02:32:08,670 --> 02:32:11,740 RESEARCHERS OF THE COUNTRY 4295 02:32:11,740 --> 02:32:12,808 PERCEIVED SUPPORT FOR THE NIH 4296 02:32:12,808 --> 02:32:14,443 ARE FOCUSED ON THE ACTUAL HEALTH 4297 02:32:14,443 --> 02:32:15,444 NEEDS OF THE AMERICAN PEOPLE 4298 02:32:15,444 --> 02:32:17,045 RATHER THAN FIGHTING POLITICAL 4299 02:32:17,045 --> 02:32:18,213 BATTLES THAT WE'RE ILL EQUIPPED 4300 02:32:18,213 --> 02:32:20,615 TO FIGHT. 4301 02:32:20,615 --> 02:32:21,717 THE SECOND SORT OF LESS HEALTHY 4302 02:32:21,717 --> 02:32:23,785 PART OF IT HAS BEEN DISRUPTIONS 4303 02:32:23,785 --> 02:32:27,022 I THINK CAUSED BY THE FACT 4304 02:32:27,022 --> 02:32:28,557 THAT -- JUST TO BE VERY BLUNT, 4305 02:32:28,557 --> 02:32:31,193 THERE'S A LOT OF DISTRUST, 4306 02:32:31,193 --> 02:32:35,664 MUTUAL DISTRUST BETWEEN FOLKS 4307 02:32:35,664 --> 02:32:38,100 WHO VOTED FOR PRESIDENT TRUMP 4308 02:32:38,100 --> 02:32:39,334 AND GENERALLY THE SCIENTIFIC 4309 02:32:39,334 --> 02:32:40,635 COMMUNITY. 4310 02:32:40,635 --> 02:32:41,737 THE SCIENTIFIC COMMUNITY, I 4311 02:32:41,737 --> 02:32:46,174 LOOKED AT SOME OF THE PEW 4312 02:32:46,174 --> 02:32:47,042 ESTIMATES OF THE PUBLIC 4313 02:32:47,042 --> 02:32:48,910 CONFIDENCE IN THE SCIENTIFIC 4314 02:32:48,910 --> 02:32:50,979 COMMUNITY TO ACT IN IT IN THE 4315 02:32:50,979 --> 02:32:52,447 BEST INTEREST OF THE PUBLIC, AND 4316 02:32:52,447 --> 02:32:53,348 THEY'RE SHOCKINGLY LOW. 4317 02:32:53,348 --> 02:32:55,851 I THINK IT'S LIKE LESS THAN 1 IN 4318 02:32:55,851 --> 02:32:57,619 4 AMERICANS ACTUALLY BELIEVE 4319 02:32:57,619 --> 02:32:59,421 THAT SCIENTISTS WORK FOR THE 4320 02:32:59,421 --> 02:33:02,124 BENEFIT OF THE AMERICAN PEOPLE. 4321 02:33:02,124 --> 02:33:03,892 ON THE OTHER SIDE, OF COURSE, 4322 02:33:03,892 --> 02:33:07,396 SCIENTISTS HAVE DEEP DISTRUST OF 4323 02:33:07,396 --> 02:33:09,965 THIS ADMINISTRATION FOR BETTER 4324 02:33:09,965 --> 02:33:12,033 OR WORSE. 4325 02:33:12,033 --> 02:33:14,870 I THINK A LOT OF THE DISRUPTIONS 4326 02:33:14,870 --> 02:33:16,037 HAVE HAPPENED BECAUSE OF THAT 4327 02:33:16,037 --> 02:33:17,572 DISTRUST, AGAIN ON BOTH SIDES. 4328 02:33:17,572 --> 02:33:19,207 I DON'T KNOW IF I CAN ACCOMPLISH 4329 02:33:19,207 --> 02:33:21,009 THIS, BUT WHEN MY GOAL IS TO TRY 4330 02:33:21,009 --> 02:33:23,879 TO BUILD A BRIDGE, BECAUSE I 4331 02:33:23,879 --> 02:33:27,749 DON'T SEE IN PRESIDENT TRUMP OR 4332 02:33:27,749 --> 02:33:29,785 IN THE FOLKS WHO I'VE INTERACTED 4333 02:33:29,785 --> 02:33:35,290 WITH ANY DESIRE TO REMOVE 4334 02:33:35,290 --> 02:33:38,794 SUPPORT, PUBLIC SUPPORT FOR THE 4335 02:33:38,794 --> 02:33:39,261 BIOMEDICAL ENTERPRISE. 4336 02:33:39,261 --> 02:33:41,496 IN FACT, QUITE THE OPPOSITE. 4337 02:33:41,496 --> 02:33:44,232 BASICALLY UNIVERSALLY, I THINK 4338 02:33:44,232 --> 02:33:46,101 IF THE BIOMEDICAL ENTERPRISE IS 4339 02:33:46,101 --> 02:33:47,402 WORKING FOR THE ADVANCEMENT OF 4340 02:33:47,402 --> 02:33:48,236 THE HEALTH OF THE AMERICAN 4341 02:33:48,236 --> 02:33:49,671 PEOPLE, WE'RE GOING TO GET 4342 02:33:49,671 --> 02:33:51,306 UNIVERSAL SUPPORT FOR IT. 4343 02:33:51,306 --> 02:33:52,974 AT THE SAME TIME, SCIENTISTS 4344 02:33:52,974 --> 02:33:56,611 NEED TO UNDERSTAND THAT WHAT 4345 02:33:56,611 --> 02:34:00,549 HAPPENED ESPECIALLY DURING THE 4346 02:34:00,549 --> 02:34:02,017 PANDEMIC HAVE REALLY DRIVEN A 4347 02:34:02,017 --> 02:34:03,051 WEDGE BETWEEN SCIENTISTS AND THE 4348 02:34:03,051 --> 02:34:07,622 AMERICAN PUBLIC. 4349 02:34:07,622 --> 02:34:10,459 TO SORT OF TALK IN WAYS THAT ARE 4350 02:34:10,459 --> 02:34:13,261 MORE RESPECTFUL FOR THE CONCERNS 4351 02:34:13,261 --> 02:34:16,298 THE AMERICAN PUBLIC HAS. 4352 02:34:16,298 --> 02:34:20,569 TALK AND WORK IN WAYS THAT ARE 4353 02:34:20,569 --> 02:34:21,736 RESPECTFUL THE WAY -- BUT THAT'S 4354 02:34:21,736 --> 02:34:22,704 MY GOAL, IS TO BUILD THAT 4355 02:34:22,704 --> 02:34:23,171 BRIDGE. 4356 02:34:23,171 --> 02:34:26,107 I DO THINK THAT SCIENCE CAN'T 4357 02:34:26,107 --> 02:34:28,743 WORK WITHOUT SUPPORT -- AMERICAN 4358 02:34:28,743 --> 02:34:30,111 SCIENCE CAN'T WORK WITHOUT 4359 02:34:30,111 --> 02:34:31,313 SUPPORT OF THE AMERICAN PUBLIC, 4360 02:34:31,313 --> 02:34:34,583 AND AMERICAN SCIENTISTS, IN 4361 02:34:34,583 --> 02:34:35,851 EXCHANGE FOR THE TREMENDOUS 4362 02:34:35,851 --> 02:34:37,252 SUPPORT THAT WE DO GET FROM THE 4363 02:34:37,252 --> 02:34:38,653 AMERICAN PUBLIC, OWE TO THE 4364 02:34:38,653 --> 02:34:40,455 AMERICAN PUBLIC TO DEVELOP 4365 02:34:40,455 --> 02:34:43,158 INCREASING LIFE EXPECTANCY 4366 02:34:43,158 --> 02:34:44,693 ANSWERS TO THE CHRONIC DISEASE 4367 02:34:44,693 --> 02:34:48,096 PROBLEMS THEY FACE, AND AVOID 4368 02:34:48,096 --> 02:34:49,297 THE SORT OF POLITICIZATION OF 4369 02:34:49,297 --> 02:34:50,765 SCIENCE, I THINK HAS LED TO THIS 4370 02:34:50,765 --> 02:34:51,733 MOMENT. 4371 02:34:51,733 --> 02:34:54,469 >> THANK YOU. 4372 02:34:54,469 --> 02:34:55,303 >> GREAT. 4373 02:34:55,303 --> 02:34:56,738 I RECOGNIZE WE ARE AT TIME FOR 4374 02:34:56,738 --> 02:34:57,873 THIS SESSION BUT THIS IS 4375 02:34:57,873 --> 02:34:59,107 OBVIOUSLY A REALLY CRITICAL 4376 02:34:59,107 --> 02:35:00,075 DIALOGUE. 4377 02:35:00,075 --> 02:35:02,277 AND SO IF JAY CAN CONTINUE FOR A 4378 02:35:02,277 --> 02:35:04,479 FEW MINUTES, WE ARE MORE THAN 4379 02:35:04,479 --> 02:35:06,181 HAPPY TO CONTINUE TO EXTEND THIS 4380 02:35:06,181 --> 02:35:06,915 SESSION. 4381 02:35:06,915 --> 02:35:09,017 SO I'LL TURN IT OVER TO KENT, 4382 02:35:09,017 --> 02:35:11,319 WHO'S NEXT. 4383 02:35:11,319 --> 02:35:12,721 >> HI, DR. BHATTACHARYA. 4384 02:35:12,721 --> 02:35:13,788 THANKS SO MUCH FOR COMING. 4385 02:35:13,788 --> 02:35:15,524 I THINK WE ALL SHARE YOUR LOVE 4386 02:35:15,524 --> 02:35:18,026 FOR THE NIH, AND WANT TO REMAIN 4387 02:35:18,026 --> 02:35:19,561 A CROWN JEWEL IN THE FEDERAL 4388 02:35:19,561 --> 02:35:20,862 GOVERNMENT, AND I THINK YOU'LL 4389 02:35:20,862 --> 02:35:23,632 FIND US ALL ON COUNCIL OF 4390 02:35:23,632 --> 02:35:25,300 COUNCILS DOING EVERYTHING WE CAN 4391 02:35:25,300 --> 02:35:26,201 TO SUPPORT YOUR EFFORTS TO 4392 02:35:26,201 --> 02:35:27,502 ENSURE THAT HAPPENS. 4393 02:35:27,502 --> 02:35:29,905 VERY BRIEFLY, I THINK I'M THE 4394 02:35:29,905 --> 02:35:31,273 ONLY VETERINARIAN ON THE 4395 02:35:31,273 --> 02:35:32,240 COUNCIL. 4396 02:35:32,240 --> 02:35:35,977 AND SO I WANTED TO ASK YOU ABOUT 4397 02:35:35,977 --> 02:35:36,511 ANIMAL RESEARCH. 4398 02:35:36,511 --> 02:35:39,214 AS YOU KNOW, DPCPSI SUPPORTS A 4399 02:35:39,214 --> 02:35:42,918 LOT OF ANIMAL RESEARCH IN THE 4400 02:35:42,918 --> 02:35:43,585 BIOMEDICAL RESEARCH FIELD, 4401 02:35:43,585 --> 02:35:45,186 INCLUDING TRAINING. 4402 02:35:45,186 --> 02:35:47,355 THOSE WHO WERE USING ANIMALS AND 4403 02:35:47,355 --> 02:35:49,658 VEAT NARIANS USING ANIMALS FOR 4404 02:35:49,658 --> 02:35:50,425 RESEARCH. 4405 02:35:50,425 --> 02:35:51,793 AND VETERINARY TRAINING. 4406 02:35:51,793 --> 02:35:54,863 SO COULD YOU COMMENT ON YOUR 4407 02:35:54,863 --> 02:35:57,265 PERSPECTIVE ON SUPPORT FOR 4408 02:35:57,265 --> 02:35:59,200 ANIMAL RESEARCH, DO YOU FORESEE 4409 02:35:59,200 --> 02:36:01,970 ANY CHANGES COMING UP, IS THE 4410 02:36:01,970 --> 02:36:03,338 REORGANIZATION THAT MAY BE 4411 02:36:03,338 --> 02:36:08,543 HAPPENING AT NIH MIGHT IMPACT IT 4412 02:36:08,543 --> 02:36:09,411 THAT? 4413 02:36:09,411 --> 02:36:09,978 ANY COMMENTS YOU MIGHT HAVE 4414 02:36:09,978 --> 02:36:10,612 BECAUSE IT IS A VERY IMPORTANT 4415 02:36:10,612 --> 02:36:10,845 SUBJECT. 4416 02:36:10,845 --> 02:36:11,146 THANK YOU. 4417 02:36:11,146 --> 02:36:11,913 >> THANK YOU, KENT. 4418 02:36:11,913 --> 02:36:13,381 SO THIS IS AN AREA WHERE I'M 4419 02:36:13,381 --> 02:36:14,349 STILL LEARNING, SO I'LL JUST 4420 02:36:14,349 --> 02:36:16,751 START WITH THAT. 4421 02:36:16,751 --> 02:36:18,119 AS A GENERAL MATTER, I THINK 4422 02:36:18,119 --> 02:36:21,556 THAT ANIMAL RESEARCH SHOULD BE 4423 02:36:21,556 --> 02:36:22,624 RESERVED FOR -- WHERE THERE 4424 02:36:22,624 --> 02:36:25,026 REALLY ISN'T AN ALTERNATIVE. 4425 02:36:25,026 --> 02:36:26,328 MY UNDERSTANDING IS THAT IN 4426 02:36:26,328 --> 02:36:30,999 RECENT YEARS, TH THEY HAVE BECOE 4427 02:36:30,999 --> 02:36:31,866 AVAILABLE ALTERNATIVES IN MANY 4428 02:36:31,866 --> 02:36:32,233 CASES. 4429 02:36:32,233 --> 02:36:33,868 I DON'T THINK WE SHOULD BECOME 4430 02:36:33,868 --> 02:36:35,470 DOGMATIC BUT IT BUT I DO THINK 4431 02:36:35,470 --> 02:36:36,571 WE SHOULD HAVE AN UNDERSTANDING 4432 02:36:36,571 --> 02:36:37,672 ABOUT THE ETHICAL CONCERNS MANY 4433 02:36:37,672 --> 02:36:39,040 DO HAVE ABOUT ANIMAL RESEARCH, 4434 02:36:39,040 --> 02:36:40,342 AND AGAIN, JUST RESERVE IT FOR 4435 02:36:40,342 --> 02:36:42,310 WHEN THERE REALLY ISN'T AN 4436 02:36:42,310 --> 02:36:42,644 ALTERNATIVE. 4437 02:36:42,644 --> 02:36:44,713 FOR THIS ACTUALLY MAYBE I CAN 4438 02:36:44,713 --> 02:36:46,081 ASK NICOLE TO WEIGH IN. 4439 02:36:46,081 --> 02:36:47,182 NICOLE HAS BEEN WORKING ON THIS 4440 02:36:47,182 --> 02:36:49,384 AREA QUITE EXTENSIVELY FOR YEARS 4441 02:36:49,384 --> 02:36:50,952 AND SHE IS GOING TO BE A CLOSE 4442 02:36:50,952 --> 02:36:53,455 ADD VIE TORADVISOR TO ME ON THI. 4443 02:36:53,455 --> 02:36:54,255 >> ABSOLUTELY. 4444 02:36:54,255 --> 02:36:54,856 HAPPY TO WEIGH IN. 4445 02:36:54,856 --> 02:36:56,524 THANK YOU. 4446 02:36:56,524 --> 02:36:59,327 SO AS YOU INDICATED, KENT, 4447 02:36:59,327 --> 02:37:00,829 ANIMAL RESEARCH HAS FOR DECADES, 4448 02:37:00,829 --> 02:37:02,998 YOU KNOW, SUPPORTED ADVANCES IN 4449 02:37:02,998 --> 02:37:03,898 BIOMEDICAL RESEARCH BUT I THINK 4450 02:37:03,898 --> 02:37:06,468 WE HAVE INSIGHTS FROM THE DRUG 4451 02:37:06,468 --> 02:37:08,670 DISCOVERY SPACE AND FROM THE 4452 02:37:08,670 --> 02:37:10,171 ENVIRONMENTAL TOXICOLOGY AND 4453 02:37:10,171 --> 02:37:12,607 HEALTH SPACE THAT DEMONSTRATE TO 4454 02:37:12,607 --> 02:37:17,278 US THAT WE CAN LEVERAGE ADVANCES 4455 02:37:17,278 --> 02:37:18,346 IN SCIENTIFIC DISCOVERY TO 4456 02:37:18,346 --> 02:37:20,782 ACTUALLY DO BETTER AND TO MOVE 4457 02:37:20,782 --> 02:37:22,484 TOWARDS MORE HUMAN BIOLOGY-BASED 4458 02:37:22,484 --> 02:37:25,220 METHODS WHETHER THAT'S 4459 02:37:25,220 --> 02:37:26,755 COMPUTATIONAL MODELS, COMPLEX IN 4460 02:37:26,755 --> 02:37:32,627 VITRO SYSTEMS, LIKELY INT 4461 02:37:32,627 --> 02:37:34,062 GRAITION OF ALL OF THOSE TYPES 4462 02:37:34,062 --> 02:37:34,696 OF TECHNOLOGIES. 4463 02:37:34,696 --> 02:37:35,697 YOU PROBABLY REMEMBER AND OTHERS 4464 02:37:35,697 --> 02:37:37,432 MAY THAT MY FIRST INTERACTION 4465 02:37:37,432 --> 02:37:38,633 WITH COUNCIL OF COUNCILS 4466 02:37:38,633 --> 02:37:40,902 ACTUALLY WAS TO DISCUSS THE 4467 02:37:40,902 --> 02:37:43,004 CONCEPT OF THE COMPLEMENT ANIMAL 4468 02:37:43,004 --> 02:37:45,473 RESEARCH AND EXPERIMENTATION, 4469 02:37:45,473 --> 02:37:47,442 THE COMPLEMENTARY COMMON FUND, 4470 02:37:47,442 --> 02:37:49,444 WHICH IS NOW A FULL-FLEDGED 4471 02:37:49,444 --> 02:37:51,613 PROGRAM AND IS IN THE PROCESS OF 4472 02:37:51,613 --> 02:37:52,914 REVIEWING APPLICATIONS AND 4473 02:37:52,914 --> 02:37:54,883 MAKING AWARDS SOON FOR REALLY 4474 02:37:54,883 --> 02:38:01,122 EXCITING NEW TECHNOLOGY VEMMENT 4475 02:38:01,122 --> 02:38:02,724 CENTERS AND A PART WILL BE A 4476 02:38:02,724 --> 02:38:04,392 QUALIFICATION AND VALIDATION 4477 02:38:04,392 --> 02:38:06,027 NETWORK TO DEVELOP VALIDATION 4478 02:38:06,027 --> 02:38:07,228 DATA PACKAGES TO HELP ENSURE 4479 02:38:07,228 --> 02:38:08,596 THAT THOSE NEW APPROACH METHODS 4480 02:38:08,596 --> 02:38:11,566 ARE REALLY ROBUST AND RELIABLE 4481 02:38:11,566 --> 02:38:15,270 AND REPLICABLE AND THEN CAN BE 4482 02:38:15,270 --> 02:38:16,471 TRANSLATED INTO BETTER PUBLIC 4483 02:38:16,471 --> 02:38:18,006 HEALTH PROTECTION AND ADDITIONAL 4484 02:38:18,006 --> 02:38:20,141 HUMAN BIOLOGY-BASED INSIGHTS IN 4485 02:38:20,141 --> 02:38:21,710 THE BIOMEDICAL RESEARCH ARENA. 4486 02:38:21,710 --> 02:38:23,912 MANY OF YOU MAY HAVE ALSO SEEN 4487 02:38:23,912 --> 02:38:25,513 THE PRESS RELEASE AND THE 4488 02:38:25,513 --> 02:38:28,049 SCIENTIFIC ROAD MAP THAT THE FDA 4489 02:38:28,049 --> 02:38:31,119 PUT OUT TWO WEEKS AGO WHERE THEY 4490 02:38:31,119 --> 02:38:31,986 REALLY HIGHLIGHTED THEIR 4491 02:38:31,986 --> 02:38:35,023 INTENTION TO PUT MUCH MORE 4492 02:38:35,023 --> 02:38:37,559 SUPPORT AND RESOURCES TOWARDS 4493 02:38:37,559 --> 02:38:40,729 SUPPORTING THIS TRANSITION 4494 02:38:40,729 --> 02:38:41,796 TOWARDS BIGGER AND BETTER 4495 02:38:41,796 --> 02:38:43,765 RELIANCE ON NEW APPROACH METHODS 4496 02:38:43,765 --> 02:38:47,368 FOR PRE-CLINICAL SAFETY TESTING 4497 02:38:47,368 --> 02:38:48,903 BEGINNING WITH MONOCLONAL 4498 02:38:48,903 --> 02:38:49,971 ANTIBODIES BUT THEY ALSO ALLUDED 4499 02:38:49,971 --> 02:38:52,807 TO KIND OF A GENERALIZATION 4500 02:38:52,807 --> 02:38:54,275 ACROSS THE PRE-CLINICAL SAFETY 4501 02:38:54,275 --> 02:38:58,379 SPACE TO HELP ENABLE BETTER DRUG 4502 02:38:58,379 --> 02:38:59,914 DISCOVERY AND HUMAN RELEVANT 4503 02:38:59,914 --> 02:39:02,650 SAFETY ASSESSMENTS, AND THEY 4504 02:39:02,650 --> 02:39:04,919 CALLED OUT NIH AS A PARTNER, A 4505 02:39:04,919 --> 02:39:05,687 REALLY CRITICAL PARTNER. 4506 02:39:05,687 --> 02:39:07,322 THEY ALSO CALLED OUT THE 4507 02:39:07,322 --> 02:39:08,356 INTERAGENCY COORDINATING 4508 02:39:08,356 --> 02:39:09,357 COMMITTEE FOR THE VALIDATION OF 4509 02:39:09,357 --> 02:39:10,792 ALTERNATIVE METHODS, WHICH AS 4510 02:39:10,792 --> 02:39:12,894 YOU KNOW IS A COMMITTEE MANDATED 4511 02:39:12,894 --> 02:39:15,530 BY CONGRESS THAT SPANS ACROSS 18 4512 02:39:15,530 --> 02:39:16,898 DIFFERENT FEDERAL PARTNERS 4513 02:39:16,898 --> 02:39:18,633 ACROSS THE GOVERNMENT, AND SO I 4514 02:39:18,633 --> 02:39:20,735 THINK THERE'S A LOT OF MOMENTUM 4515 02:39:20,735 --> 02:39:23,438 IN THIS SPACE, AND THERE'S GOING 4516 02:39:23,438 --> 02:39:26,508 TO CERTAINLY BE I THINK A 4517 02:39:26,508 --> 02:39:30,345 RENEWED FOCUS AND ENERGY PUT 4518 02:39:30,345 --> 02:39:32,413 INTO ENSURING THAT WE ARE USING 4519 02:39:32,413 --> 02:39:36,151 THE BEST SCIENCE POSSIBLE TO 4520 02:39:36,151 --> 02:39:39,854 SUPPORT BIOMEDICAL RESEARCH, 4521 02:39:39,854 --> 02:39:41,790 MECHANISTIC INSIGHTS AND 4522 02:39:41,790 --> 02:39:44,826 DISCOVERIES AND PUBLIC HEALTH 4523 02:39:44,826 --> 02:39:45,126 PROTECTION. 4524 02:39:45,126 --> 02:39:50,098 >> THANKS, I'M ENCOURAGED TO 4525 02:39:50,098 --> 02:39:53,134 HEAR THE MENTION OF THE NEED FOR 4526 02:39:53,134 --> 02:39:55,670 VALIDATION OF THE NAMs, VERY 4527 02:39:55,670 --> 02:39:56,838 IMPORTANT BEFORE TRANSITIONING 4528 02:39:56,838 --> 02:39:58,072 TO HUMAN USE, SO WONDERFUL. 4529 02:39:58,072 --> 02:39:58,840 THANKS VERY MUCH, BOTH. 4530 02:39:58,840 --> 02:40:00,909 >> THANK YOU. 4531 02:40:00,909 --> 02:40:03,144 RHONDA, PLEASE GO AHEAD. 4532 02:40:03,144 --> 02:40:05,180 >> THANK YOU SO MUCH. 4533 02:40:05,180 --> 02:40:08,449 I REALLY APPRECIATE THE VISION 4534 02:40:08,449 --> 02:40:09,984 THAT YOU'VE BROUGHT FORWARD, AND 4535 02:40:09,984 --> 02:40:14,355 I CAN SAY -- I ALMOST WANT TO 4536 02:40:14,355 --> 02:40:16,057 SAY HALLELUJAH FROM SOME DEGREE 4537 02:40:16,057 --> 02:40:19,260 FROM THE STANDPOINT MANY OF THE 4538 02:40:19,260 --> 02:40:20,662 THINGS YOU MENTIONED HAVE BEEN 4539 02:40:20,662 --> 02:40:21,563 LONG TERM THINGS I HAVE OBSERVED 4540 02:40:21,563 --> 02:40:23,498 BUT ALSO WONDERED WHETHER OR NOT 4541 02:40:23,498 --> 02:40:24,799 THERE WOULD BE EVER A CHANGE. 4542 02:40:24,799 --> 02:40:26,234 THE FIRST THING IS 4543 02:40:26,234 --> 02:40:26,768 REPRODUCIBILITY. 4544 02:40:26,768 --> 02:40:29,737 I'VE BEEN WITH THE NIH IN 4545 02:40:29,737 --> 02:40:33,875 ADVISORY CAPACITY NOW, TOTAL 4546 02:40:33,875 --> 02:40:35,076 YEARS, 12 YEARS, AND THE WHOLE 4547 02:40:35,076 --> 02:40:36,744 ISSUE OF REPRODUCIBILITY HAS 4548 02:40:36,744 --> 02:40:38,913 ALWAYS BEEN A THORN IN THE SIDE, 4549 02:40:38,913 --> 02:40:40,181 PRIMARILY BECAUSE I WAS ALWAYS 4550 02:40:40,181 --> 02:40:45,220 TOLD IT WAS NOT FUNDED BY NIH. 4551 02:40:45,220 --> 02:40:46,487 THE PROBLEM WITH THAT IS THAT 4552 02:40:46,487 --> 02:40:47,922 THE ADOPTION OF RESEARCH THAT 4553 02:40:47,922 --> 02:40:50,358 SHOWS REALLY GOOD PROMISE IS 4554 02:40:50,358 --> 02:40:55,930 HARD TO MAKE THAT TRANSLATION 4555 02:40:55,930 --> 02:40:57,332 INTO THE ARENA OF THE REAL 4556 02:40:57,332 --> 02:41:00,068 WORLD, ACCEPTING THAT PARTICULAR 4557 02:41:00,068 --> 02:41:00,668 RESEARCH. 4558 02:41:00,668 --> 02:41:03,805 SO I REALLY, REALLY SUPPORT WHAT 4559 02:41:03,805 --> 02:41:04,505 YOU'RE SAYING. 4560 02:41:04,505 --> 02:41:06,507 I WOULD ALSO ADD THAT MAYBE AS 4561 02:41:06,507 --> 02:41:10,879 PART OF THIS REPRODUCIBILITY, 4562 02:41:10,879 --> 02:41:13,715 THAT THE NEXT STUDY ALSO BE DONE 4563 02:41:13,715 --> 02:41:16,951 IN THE REAL WORLD SETTING WITH 4564 02:41:16,951 --> 02:41:18,620 LARGE NUMBERS. 4565 02:41:18,620 --> 02:41:20,588 THAT'S ONE OF THE THINGS THAT 4566 02:41:20,588 --> 02:41:22,023 MANY TIMES IS ABSENT, 4567 02:41:22,023 --> 02:41:25,693 PARTICULARLY IF I IT'S RELEGATED 4568 02:41:25,693 --> 02:41:26,995 TO AN ACADEMIC SETTING THAT 4569 02:41:26,995 --> 02:41:29,530 DOESN'T HAVE THE REACH, AS SOME 4570 02:41:29,530 --> 02:41:31,366 OF THE OTHER PLAYERS IN THE 4571 02:41:31,366 --> 02:41:33,701 FIELD LIKE HEALTH SYSTEMS, 4572 02:41:33,701 --> 02:41:36,070 INSURANCE COMPANIES, EMPLOYER, 4573 02:41:36,070 --> 02:41:39,407 ALL OF THEM HAVE LARGER REACH, 4574 02:41:39,407 --> 02:41:40,642 MANY OF THEM HAVE THE DATA THAT 4575 02:41:40,642 --> 02:41:42,744 YOU'RE TALKING ABOUT, AND 4576 02:41:42,744 --> 02:41:44,479 CERTAINLY CAN AND HAVE BEEN 4577 02:41:44,479 --> 02:41:46,447 ENGAGED IN REPRODUCING RESEARCH 4578 02:41:46,447 --> 02:41:47,315 ON THEIR OWN. 4579 02:41:47,315 --> 02:41:50,151 SO I JUST WANT TO BRING THAT UP 4580 02:41:50,151 --> 02:41:52,353 TO SAY. 4581 02:41:52,353 --> 02:41:54,522 ALSO, YOUR EMPHASIS ON DATA, 4582 02:41:54,522 --> 02:41:57,025 DATA TRANSPARENCY, AND I'M 4583 02:41:57,025 --> 02:41:58,359 HOPING WITH THAT SOME 4584 02:41:58,359 --> 02:41:59,527 STANDARDIZATION SO THAT THOSE 4585 02:41:59,527 --> 02:42:01,062 THAT ARE ENGAGED IN RESEARCH ARE 4586 02:42:01,062 --> 02:42:02,897 USING SOME STANDARD PARAMETERS 4587 02:42:02,897 --> 02:42:05,099 THAT WILL ALLOW THERE TO BE 4588 02:42:05,099 --> 02:42:07,201 CROSS COMPARABILITY ACROSS MANY 4589 02:42:07,201 --> 02:42:08,703 OF THE POPULATIONS AND MANY OF 4590 02:42:08,703 --> 02:42:11,005 THE STUDIES THAT ARE OUT THERE. 4591 02:42:11,005 --> 02:42:13,775 I PARTICULARLY WANT TO MENTION 4592 02:42:13,775 --> 02:42:16,811 ALL OF US AS BEING A VERY GOOD 4593 02:42:16,811 --> 02:42:19,314 EXAMPLE OF BEING ABLE TO USE 4594 02:42:19,314 --> 02:42:22,283 THEIR ABILITY TO RECRUIT THE 4595 02:42:22,283 --> 02:42:24,252 PUBLIC, BUT ALSO BEGINNING TO 4596 02:42:24,252 --> 02:42:26,854 RECRUIT OTHER PARTNERS IN THIS 4597 02:42:26,854 --> 02:42:28,623 TYPE OF VENTURE WHERE YOU'RE 4598 02:42:28,623 --> 02:42:30,892 COLLECTING A WIDE RANGE OF 4599 02:42:30,892 --> 02:42:32,093 INFORMATION, ALLOWING 4600 02:42:32,093 --> 02:42:33,962 RESEARCHERS TO GO IN AND BEGIN 4601 02:42:33,962 --> 02:42:36,030 TO CREATE NOVEL IDEAS AND 4602 02:42:36,030 --> 02:42:37,365 FINDINGS WHICH IS VERY, VERY 4603 02:42:37,365 --> 02:42:39,534 EXCITING AND I THINK THAT IS ONE 4604 02:42:39,534 --> 02:42:41,402 OF THE THINGS THAT IS VERY, VERY 4605 02:42:41,402 --> 02:42:43,371 IMPORTANT AND CERTAINLY HAS BEEN 4606 02:42:43,371 --> 02:42:48,076 DONE WELL BY NIH. 4607 02:42:48,076 --> 02:42:49,510 THE LAST PIECE I HAVE IS AROUND 4608 02:42:49,510 --> 02:42:49,844 COMMUNICATION. 4609 02:42:49,844 --> 02:42:51,446 I THINK ONE OF THE THINGS THAT 4610 02:42:51,446 --> 02:42:53,548 IS CERTAINLY WITHIN NOT WITHOUT 4611 02:42:53,548 --> 02:42:55,516 A LOT OF EFFORT ON MANY PARTS OF 4612 02:42:55,516 --> 02:42:58,553 NIH AS WELL AS NATIONAL ACADEMY 4613 02:42:58,553 --> 02:42:59,988 OF MEDICINE AND OTHERS HAVE BEEN 4614 02:42:59,988 --> 02:43:04,892 IN THOSE CIRCLES, IT SEEMS AS 4615 02:43:04,892 --> 02:43:06,227 THOUGH WE'RE NOT ABLE TO 4616 02:43:06,227 --> 02:43:07,095 COMMUNICATE EFFECTIVELY WITH THE 4617 02:43:07,095 --> 02:43:09,597 PUBLIC TO HELP THEM UNDERSTAND. 4618 02:43:09,597 --> 02:43:11,332 AND I THINK YOU'RE ABSOLUTELY 4619 02:43:11,332 --> 02:43:14,168 RIGHT, THAT THIS TRUST THAT GREW 4620 02:43:14,168 --> 02:43:16,137 TREMENDOUSLY DURING THE COVID 4621 02:43:16,137 --> 02:43:17,972 ERA HAD A LOT TO DO WITH NOT 4622 02:43:17,972 --> 02:43:19,173 UNDERSTANDING, NOT EVEN 4623 02:43:19,173 --> 02:43:21,676 REALIZING THAT SCIENCE IS 4624 02:43:21,676 --> 02:43:23,144 ITERATIVE, PLRLY WHEN IT'S 4625 02:43:23,144 --> 02:43:23,578 SOMETHING NEW. 4626 02:43:23,578 --> 02:43:25,546 YOU DON'T HAVE THE ABSOLUTE 4627 02:43:25,546 --> 02:43:26,748 ANSWERS AT THAT POINT, BUT THE 4628 02:43:26,748 --> 02:43:27,815 PUBLIC WASN'T LISTENING OR 4629 02:43:27,815 --> 02:43:30,018 HEARING OR UNDERSTANDING THAT. 4630 02:43:30,018 --> 02:43:32,854 SO I'M HOPING THAT PART OF YOUR 4631 02:43:32,854 --> 02:43:36,024 INITIATIVE WILL DEVOTE TIME, 4632 02:43:36,024 --> 02:43:37,558 EFFORT AND RESOURCES TO BEING 4633 02:43:37,558 --> 02:43:41,029 ABLE TO COMMUNICATE ON A 4634 02:43:41,029 --> 02:43:42,463 LAYMAN'S LEVEL TO HELP BUILD 4635 02:43:42,463 --> 02:43:43,865 THEIR LITERACY AS IT RELATES TO 4636 02:43:43,865 --> 02:43:46,067 WHAT IS BEING DONE SO THERE'S 4637 02:43:46,067 --> 02:43:47,835 MORE ACCEPTANCE OF THE FINDINGS 4638 02:43:47,835 --> 02:43:49,103 THAT COME WITH TIME. 4639 02:43:49,103 --> 02:43:52,707 SO AGAIN, THANK YOU SO MUCH FOR 4640 02:43:52,707 --> 02:43:54,675 YOUR IDEAS, BECAUSE I THINK 4641 02:43:54,675 --> 02:43:56,010 THEY'RE DEFINITELY WELL NEEDED 4642 02:43:56,010 --> 02:43:58,479 AND I CERTAINLY SEE THIS AS 4643 02:43:58,479 --> 02:43:59,047 BEING EXCEPTIONAL. 4644 02:43:59,047 --> 02:44:01,349 I WORK WITH UNITED HEALTH GROUP, 4645 02:44:01,349 --> 02:44:02,750 AND THINGS THAT YOU'RE TALKING 4646 02:44:02,750 --> 02:44:04,385 ABOUT ARE DEFINITELY THE THINGS 4647 02:44:04,385 --> 02:44:05,953 THAT ARE VERY, VERY IMPORTANT 4648 02:44:05,953 --> 02:44:07,321 FROM MY STANDPOINT OF VIEW AND 4649 02:44:07,321 --> 02:44:07,889 OUR ORGANIZATION. 4650 02:44:07,889 --> 02:44:13,361 THANK YOU. 4651 02:44:13,361 --> 02:44:14,862 >> RHONDA, THANK YOU FOR THOSE 4652 02:44:14,862 --> 02:44:15,563 COMMENTS. 4653 02:44:15,563 --> 02:44:16,597 I DON'T HAVE MUCH TO ADD OTHER 4654 02:44:16,597 --> 02:44:17,498 THAN LET'S WORK TOGETHER ON 4655 02:44:17,498 --> 02:44:19,333 THESE THINGS. 4656 02:44:19,333 --> 02:44:20,701 THE AVAILABILITY, DATA RESOURCES 4657 02:44:20,701 --> 02:44:24,138 AT SCALE FOR RESEARCHERS MORE 4658 02:44:24,138 --> 02:44:26,941 EASILY, REPRODUCIBILITY, 4659 02:44:26,941 --> 02:44:28,209 STANDARDS OF REPRODUCIBILITY FOR 4660 02:44:28,209 --> 02:44:29,744 THE DIFFERENT DISCIPLINES AND 4661 02:44:29,744 --> 02:44:31,379 INSTITUTES, ALL THOSE ARE QUITE 4662 02:44:31,379 --> 02:44:34,549 IMPORTANT TO ME. 4663 02:44:34,549 --> 02:44:36,918 I THINK AS FAR AS THE LAST 4664 02:44:36,918 --> 02:44:38,920 COMMENT ABOUT LIKE PUBLIC TRUST, 4665 02:44:38,920 --> 02:44:45,026 ONE IDEA THAT I HAD WAS THAT 4666 02:44:45,026 --> 02:44:47,428 BEFORE I BECAME NIH DIRECTOR, I 4667 02:44:47,428 --> 02:44:50,264 WAS RUNNING PODCAST WITH THE 4668 02:44:50,264 --> 02:44:52,233 NAME ILLUSION OF CONSENSUS, 4669 02:44:52,233 --> 02:44:52,867 ANOTHER, SCIENCE FROM THE 4670 02:44:52,867 --> 02:44:53,201 FRINGE. 4671 02:44:53,201 --> 02:44:55,369 I'D LIKE TO USE SOME OF THOSE 4672 02:44:55,369 --> 02:44:57,672 SKILLS THAT I GAINED 4673 02:44:57,672 --> 02:45:00,308 INTERVIEWING SCIENTISTS. 4674 02:45:00,308 --> 02:45:02,143 THE AIM OF THOSE PODCASTS WAS 4675 02:45:02,143 --> 02:45:05,313 THE PUBLIC AT LARGE, TO BRING 4676 02:45:05,313 --> 02:45:06,614 SCIENTIFIC IDEAS THAT PEOPLE 4677 02:45:06,614 --> 02:45:09,350 MAYBE HADN'T SEEN TO THE 4678 02:45:09,350 --> 02:45:10,685 ATTENTION OF THE PUBLIC IN A WAY 4679 02:45:10,685 --> 02:45:13,387 THAT'S UNDERSTANDABLE TO THE 4680 02:45:13,387 --> 02:45:14,722 PUBLIC. 4681 02:45:14,722 --> 02:45:15,823 I THINK OUR SCIENCE 4682 02:45:15,823 --> 02:45:19,427 COMMUNICATION EFFORTS AT THE 4683 02:45:19,427 --> 02:45:20,128 NIH, IT'S SOMETIMES DIFFICULT 4684 02:45:20,128 --> 02:45:22,697 FOR ME ON THE OUTSIDE TO TELL 4685 02:45:22,697 --> 02:45:23,564 WHO THEY'RE AIMED AT. 4686 02:45:23,564 --> 02:45:25,733 ARE THEY AIMED AT OTHER 4687 02:45:25,733 --> 02:45:26,934 SCIENTISTS, THE PUBLIC, IF IT 4688 02:45:26,934 --> 02:45:28,469 WAS THE PUBLIC, I OFTEN VIEWED 4689 02:45:28,469 --> 02:45:30,972 IT AS LIKE THE PEOPLE -- THAT WE 4690 02:45:30,972 --> 02:45:32,173 WERE TALKING DOWN TO REGULAR 4691 02:45:32,173 --> 02:45:32,940 PEOPLE RATHER THAN TRYING TO 4692 02:45:32,940 --> 02:45:34,709 TALK WITH THEM. 4693 02:45:34,709 --> 02:45:36,844 SO I WANT TO WORK TO FIX THAT. 4694 02:45:36,844 --> 02:45:38,179 I MEAN, I THINK OUR 4695 02:45:38,179 --> 02:45:39,580 COMMUNICATION WITH SCIENTISTS IS 4696 02:45:39,580 --> 02:45:41,682 ACTUALLY PRETTY GOOD, AND WE 4697 02:45:41,682 --> 02:45:43,184 HAVE PUBMED, FOR INSTANCE, WE 4698 02:45:43,184 --> 02:45:44,519 CAN COMMUNICATE WITH SCIENTISTS 4699 02:45:44,519 --> 02:45:47,655 ALL THE TIME IN LANGUAGES THAT 4700 02:45:47,655 --> 02:45:48,322 SCIENTISTS BENEFIT FROM AND 4701 02:45:48,322 --> 02:45:48,756 UNDERSTAND. 4702 02:45:48,756 --> 02:45:50,291 WE CAN DO BETTER FOR SURE. 4703 02:45:50,291 --> 02:45:51,259 BUT OUR COMMUNICATION WITH THE 4704 02:45:51,259 --> 02:45:52,927 PUBLIC, I THINK, NEEDS 4705 02:45:52,927 --> 02:45:53,828 IMPROVEMENT, AND I'M GOING TO 4706 02:45:53,828 --> 02:45:54,662 WORK HARD ON THAT. 4707 02:45:54,662 --> 02:45:56,297 >> ONE THING I WOULD SUGGEST, 4708 02:45:56,297 --> 02:45:57,932 THINK ABOUT WHAT THE PUBLIC GOES 4709 02:45:57,932 --> 02:45:58,332 TO. 4710 02:45:58,332 --> 02:46:00,201 I KNOW IT MAY SOUND LIKE A DIRTY 4711 02:46:00,201 --> 02:46:03,171 WORD, BUT SOCIAL MEDIA IS SO 4712 02:46:03,171 --> 02:46:04,805 STRONG, AND CERTAINLY A AVENUE 4713 02:46:04,805 --> 02:46:05,806 THAT THEY GO TO. 4714 02:46:05,806 --> 02:46:07,141 THEY JUST DON'T HAVE SOMETHING 4715 02:46:07,141 --> 02:46:08,509 THAT GIVES THEM A SEAL OF 4716 02:46:08,509 --> 02:46:10,912 APPROVAL THAT THIS IS LEGIT, AND 4717 02:46:10,912 --> 02:46:12,013 THAT THIS MAKES SENSE. 4718 02:46:12,013 --> 02:46:13,781 SO I'M JUST GONNA SAY THAT AND 4719 02:46:13,781 --> 02:46:15,650 LEAVE THAT ALONE. 4720 02:46:15,650 --> 02:46:17,351 >> I THINK WE HAVE NO CHOICE. 4721 02:46:17,351 --> 02:46:18,686 WE HAVE TO DEAL WITH THE PUBLIC 4722 02:46:18,686 --> 02:46:19,320 WHERE THEY ARE. 4723 02:46:19,320 --> 02:46:22,623 I ACTUALLY LIKE SOCIAL MEDIA. 4724 02:46:22,623 --> 02:46:24,358 I FOUND TWITTER TO BE A VERY 4725 02:46:24,358 --> 02:46:26,127 EFFECTIVE WAY TO REACH THE 4726 02:46:26,127 --> 02:46:27,862 PUBLIC BEFORE I BECAME NIH 4727 02:46:27,862 --> 02:46:28,396 DIRECTOR. 4728 02:46:28,396 --> 02:46:32,433 WE NEED TO UPDATE OUR STRATEGY 4729 02:46:32,433 --> 02:46:33,534 SO THAT WE REACH THE PUBLIC 4730 02:46:33,534 --> 02:46:35,269 WHERE THEY ARE IN THE LANGUAGE 4731 02:46:35,269 --> 02:46:36,137 THEY UNDERSTAND AND NOT TALK 4732 02:46:36,137 --> 02:46:37,972 DOWN TO THEM BUT ACTUALLY CAN 4733 02:46:37,972 --> 02:46:39,340 HAVE CONVERSATIONS WITH THEM. 4734 02:46:39,340 --> 02:46:40,875 I THINK THAT'S THE WAY YOU BUILD 4735 02:46:40,875 --> 02:46:42,643 TRUST. 4736 02:46:42,643 --> 02:46:43,811 >> OKAY, GREAT. 4737 02:46:43,811 --> 02:46:45,580 JEAN? 4738 02:46:45,580 --> 02:46:47,048 >> THANK YOU SO MUCH FOR SHARING 4739 02:46:47,048 --> 02:46:47,915 YOUR VISION WITH US. 4740 02:46:47,915 --> 02:46:49,550 WE REALLY APPRECIATE IT. 4741 02:46:49,550 --> 02:46:52,253 AND THERE'S SO MANY THINGS THAT 4742 02:46:52,253 --> 02:46:53,387 WE ARE ALIGNED ON. 4743 02:46:53,387 --> 02:46:54,689 ONE OF THE THINGS THAT I NEED 4744 02:46:54,689 --> 02:46:56,324 CLARIFICATION ON, IF YOU COULD 4745 02:46:56,324 --> 02:46:57,758 HELP ME UNDERSTAND, YOU TALKED 4746 02:46:57,758 --> 02:47:00,194 ABOUT ACADEMIC FREEDOM AND 4747 02:47:00,194 --> 02:47:00,928 SUPPORTING ACADEMIC FREEDOM. 4748 02:47:00,928 --> 02:47:02,196 AND ON THE OTHER SIDE, I'M 4749 02:47:02,196 --> 02:47:04,031 THINKING THERE ARE TOPICS THAT 4750 02:47:04,031 --> 02:47:06,200 WE'RE NOT READY TO FUND AT NIH 4751 02:47:06,200 --> 02:47:07,635 ANYMORE, IF I UNDERSTAND THIS 4752 02:47:07,635 --> 02:47:07,969 CORRECTLY. 4753 02:47:07,969 --> 02:47:09,937 SO I WANT CLARIFICATION ON -- 4754 02:47:09,937 --> 02:47:12,240 FOR ME ACADEMIC FREEDOM IS, YOU 4755 02:47:12,240 --> 02:47:13,307 KNOW, THE ABILITY TO STUDY 4756 02:47:13,307 --> 02:47:15,409 WHATEVER IT IS I WANT TO STUDY, 4757 02:47:15,409 --> 02:47:17,278 AND HOW DOES THAT FIT TOGETHER. 4758 02:47:17,278 --> 02:47:19,213 AND THE SECOND THING IS MORE IN 4759 02:47:19,213 --> 02:47:20,514 ALIGNMENT WITH WHAT WE JUST 4760 02:47:20,514 --> 02:47:21,082 HEARD. 4761 02:47:21,082 --> 02:47:23,284 I WONDERED IF THERE WAS ANOTHER 4762 02:47:23,284 --> 02:47:25,119 WAY WE COULD APPROACH WHAT I 4763 02:47:25,119 --> 02:47:27,188 CALL SCIENCE AND SOCIETY, THAT 4764 02:47:27,188 --> 02:47:29,357 IT'S A DIALOGUE BETWEEN THE 4765 02:47:29,357 --> 02:47:30,891 GENERAL FICK PLIK AND US. 4766 02:47:30,891 --> 02:47:32,226 WE TALK TO EACH OTHER ALL THE 4767 02:47:32,226 --> 02:47:33,861 TIME, WE GET IT, WE GET EACH 4768 02:47:33,861 --> 02:47:34,895 OTHER, WE UNDERSTAND IT, WE'RE 4769 02:47:34,895 --> 02:47:36,731 IN THE SAME ECOSYSTEM TOGETHER, 4770 02:47:36,731 --> 02:47:38,232 BUT I THINK WHAT WE'RE NOT DOING 4771 02:47:38,232 --> 02:47:39,867 WELL, AND I TOTALLY AGREE, IS 4772 02:47:39,867 --> 02:47:41,736 REACHING THE PUBLIC WHERE THEY 4773 02:47:41,736 --> 02:47:43,471 ARE. 4774 02:47:43,471 --> 02:47:45,306 BUT IT STILL AGAIN, TO ME, THAT 4775 02:47:45,306 --> 02:47:46,307 COMMUNICATION CAN'T BE ONE WAY. 4776 02:47:46,307 --> 02:47:47,608 WE CAN'T TALK AT THEM AS YOU 4777 02:47:47,608 --> 02:47:48,175 SAID. 4778 02:47:48,175 --> 02:47:49,477 WHEN WE SPEAK WITH THEM, I THINK 4779 02:47:49,477 --> 02:47:51,112 WE HAVE TO BRING THEM INTO 4780 02:47:51,112 --> 02:47:51,545 CONVERSATION. 4781 02:47:51,545 --> 02:47:54,849 SO I WOULD LOVE TO SEE US STAND 4782 02:47:54,849 --> 02:47:57,585 UP AN OFFICE THAT'S RATHER 4783 02:47:57,585 --> 02:47:58,352 ROBUST IN HAVING THAT 4784 02:47:58,352 --> 02:47:59,420 CONVERSATION BECAUSE WE CAN'T 4785 02:47:59,420 --> 02:48:00,288 BUILD TRUST WITHOUT 4786 02:48:00,288 --> 02:48:02,423 CONVERSATION, WE CAN'T TELL THEM 4787 02:48:02,423 --> 02:48:03,190 WHAT WE'RE DOING AND THEY CAN'T 4788 02:48:03,190 --> 02:48:05,059 SAY I HATE YOU FOR THIS OR I 4789 02:48:05,059 --> 02:48:06,160 DON'T TRUST YOU, IT'S NOT GOING 4790 02:48:06,160 --> 02:48:07,828 TO WORK IN THE LONG TERM. 4791 02:48:07,828 --> 02:48:10,331 SO FOR A SUSTAINABLE MODEL WHERE 4792 02:48:10,331 --> 02:48:11,432 SCIENCE AND SOCIETY INTERACT IN 4793 02:48:11,432 --> 02:48:14,068 WAYS THAT YOU JUST TALKED ABOUT, 4794 02:48:14,068 --> 02:48:17,905 AND A PODCAST, MANY OF THOSE, IT 4795 02:48:17,905 --> 02:48:20,174 CAN'T JUST BE ONE ROUTE FOR US 4796 02:48:20,174 --> 02:48:21,042 TO UNDERSTAND THIS, BUT I'M 4797 02:48:21,042 --> 02:48:22,710 REALLY STRUGGLING WITH -- I 4798 02:48:22,710 --> 02:48:23,911 THINK WE WORK SO HARD ON BEHALF 4799 02:48:23,911 --> 02:48:25,546 OF THE PUBLIC AND YET THEY DON'T 4800 02:48:25,546 --> 02:48:27,415 KNOW IT, SO THAT'S A STRUGGLE, 4801 02:48:27,415 --> 02:48:28,949 THAT'S A REAL STRUGGLE, THAT'S A 4802 02:48:28,949 --> 02:48:30,184 SADNESS ACTUALLY, SO HOW DO WE 4803 02:48:30,184 --> 02:48:31,686 TRY TO ADDRESS IT TOGETHER. 4804 02:48:31,686 --> 02:48:33,521 >> JEAN, THANK YOU FOR THOSE 4805 02:48:33,521 --> 02:48:34,188 QUESTIONS. 4806 02:48:34,188 --> 02:48:37,892 SO FIRST ON ACADEMIC FREEDOM, I 4807 02:48:37,892 --> 02:48:40,194 THINK TO ME THE QUESTION OF 4808 02:48:40,194 --> 02:48:40,961 ACADEMIC FREEDOM ISN'T CAN I 4809 02:48:40,961 --> 02:48:42,496 WORK ON ANYTHING I WANT. 4810 02:48:42,496 --> 02:48:45,232 I MEAN, THAT IS PART OF ACADEMIC 4811 02:48:45,232 --> 02:48:49,837 FREEDOM, BUT IT'S DISTINCT FROM 4812 02:48:49,837 --> 02:48:51,572 WHAT -- THE NIH HAS LIMITED 4813 02:48:51,572 --> 02:48:55,609 RESOURCES, SO WHAT DOES THE NIH 4814 02:48:55,609 --> 02:48:57,678 INVEST IN, TO ME THE KEY 4815 02:48:57,678 --> 02:48:59,347 QUESTION IS, ARE WE INVESTING IN 4816 02:48:59,347 --> 02:49:01,182 THINGS THAT WILL MEET OUR 4817 02:49:01,182 --> 02:49:02,316 MISSION, ADVANCING THE HEALTH 4818 02:49:02,316 --> 02:49:04,285 AND LONGEVITY OF THE AMERICAN 4819 02:49:04,285 --> 02:49:06,220 PEOPLE, ADVANCING SCIENCE TO 4820 02:49:06,220 --> 02:49:07,288 ADVANCE THE LONGEVITY OF THE 4821 02:49:07,288 --> 02:49:07,788 AMERICAN PEOPLE. 4822 02:49:07,788 --> 02:49:09,090 THAT'S THE QUESTION. 4823 02:49:09,090 --> 02:49:11,058 SO THAT'S NOT A QUESTION OF 4824 02:49:11,058 --> 02:49:11,826 ACADEMIC FREEDOM, THAT'S A 4825 02:49:11,826 --> 02:49:13,894 QUESTION OF HOW DO WE SHEPPARD 4826 02:49:13,894 --> 02:49:18,132 SQUARSCARCE RESOURCES SO WE MEEE 4827 02:49:18,132 --> 02:49:18,499 MISSION. 4828 02:49:18,499 --> 02:49:20,034 BUT WITHIN THAT, THERE SHOULD BE 4829 02:49:20,034 --> 02:49:21,035 ACADEMIC FREEDOM. 4830 02:49:21,035 --> 02:49:23,938 IF SOMEBODY WRITES A PAPER THAT 4831 02:49:23,938 --> 02:49:25,873 HAS A SCIENTIFIC ADVANCE THAT 4832 02:49:25,873 --> 02:49:27,074 CONTRADICTS AN IDEA THAT I'VE 4833 02:49:27,074 --> 02:49:28,576 HAD, EVEN THOUGH I'M NIH 4834 02:49:28,576 --> 02:49:30,444 DIRECTOR, THAT PERSON SHOULD 4835 02:49:30,444 --> 02:49:31,879 HAVE THE ABSOLUTE RIGHT TO BE 4836 02:49:31,879 --> 02:49:33,314 ABLE TO PUBLISH THAT PAPER AND 4837 02:49:33,314 --> 02:49:34,482 TO SAY WHAT THEY BELIEVE. 4838 02:49:34,482 --> 02:49:35,916 THEY SHOULD BE ABLE TO 4839 02:49:35,916 --> 02:49:37,351 CONTRADICT ME OR ANYBODY ELSE. 4840 02:49:37,351 --> 02:49:38,786 SCIENCE ADVANCES WHEN PEOPLE 4841 02:49:38,786 --> 02:49:41,622 DISAGREE WITH EACH OTHER, HAVE 4842 02:49:41,622 --> 02:49:42,823 DIFFERENT CONCRETE HYPOTHESES 4843 02:49:42,823 --> 02:49:44,358 AND THEN YOU DO EXPERIMENTS THAT 4844 02:49:44,358 --> 02:49:46,761 DETERMINE ONE IS RIGHT AND 4845 02:49:46,761 --> 02:49:47,528 ONE'S. 4846 02:49:47,528 --> 02:49:48,162 AND THAT DISCUSSION REALLY IS 4847 02:49:48,162 --> 02:49:49,330 THE CORE AND HEART OF ACADEMIC 4848 02:49:49,330 --> 02:49:51,465 FREEDOM. 4849 02:49:51,465 --> 02:49:53,234 AS NIH DIRECTOR, OF COURSE, I 4850 02:49:53,234 --> 02:49:54,535 DON'T HAVE ANY CAPACITY OR ANY 4851 02:49:54,535 --> 02:49:55,736 DESIRE TO STOP PEOPLE FROM 4852 02:49:55,736 --> 02:49:57,371 SAYING OR THINKING THINGS THAT 4853 02:49:57,371 --> 02:49:59,340 THEY WANT TO SAY IN THE 4854 02:49:59,340 --> 02:50:02,510 SCIENTIFIC COMMUNITY AT LARGE. 4855 02:50:02,510 --> 02:50:04,845 THE POWER THAT I WILL HAVE, AND 4856 02:50:04,845 --> 02:50:08,549 OF COURSE IT'S LIMITED AND 4857 02:50:08,549 --> 02:50:09,550 ADVISED BY YOU ALL AND OTHER 4858 02:50:09,550 --> 02:50:11,519 FOLKS, IS WHERE DO WE PUT OUR 4859 02:50:11,519 --> 02:50:12,920 SCARCE RESOURCES SO THAT WE 4860 02:50:12,920 --> 02:50:13,921 ADVANCE THE HEALTH OF THE 4861 02:50:13,921 --> 02:50:15,356 AMERICAN PEOPLE? 4862 02:50:15,356 --> 02:50:21,061 JUST VERY -- I THINK -- SUBTEXT 4863 02:50:21,061 --> 02:50:22,763 TO YOUR QUESTION, THE 4864 02:50:22,763 --> 02:50:24,031 PRESIDENT'S ORDER ON DEI 4865 02:50:24,031 --> 02:50:24,999 INITIATIVES I THINK ARE ONE OF 4866 02:50:24,999 --> 02:50:26,634 THESE THINGS WHERE I THINK IT'S 4867 02:50:26,634 --> 02:50:27,635 MISUNDERSTOOD. 4868 02:50:27,635 --> 02:50:30,137 I DON'T THINK THAT THE -- I READ 4869 02:50:30,137 --> 02:50:32,339 THOSE CAREFULLY AND I DON'T 4870 02:50:32,339 --> 02:50:34,975 THINK THAT THEY'RE AIMED AT 4871 02:50:34,975 --> 02:50:36,076 STOPPING FUNDAMENTAL RESEARCH 4872 02:50:36,076 --> 02:50:37,378 THAT ADVANCES THE HEALTH AND 4873 02:50:37,378 --> 02:50:39,447 WELL-BEING OF MINORITY POP 4874 02:50:39,447 --> 02:50:39,780 POPULATIONS. 4875 02:50:39,780 --> 02:50:40,881 I WOULDN'T HAVE ACCEPTED THIS 4876 02:50:40,881 --> 02:50:41,882 JOB IF THAT WAS THE CASE. 4877 02:50:41,882 --> 02:50:43,083 I THINK THAT THE HEALTH AND 4878 02:50:43,083 --> 02:50:44,952 WELL-BEING OF MINORITY 4879 02:50:44,952 --> 02:50:46,454 POPULATIONS ARE -- AS WELL AS 4880 02:50:46,454 --> 02:50:47,354 EVERY AMERICAN ARE A CENTRAL 4881 02:50:47,354 --> 02:50:48,556 FOCUS OF THE NIH AND WILL 4882 02:50:48,556 --> 02:50:51,091 CONTINUE TO BE UNDER MY WATCH. 4883 02:50:51,091 --> 02:50:55,262 AND SO THE QUESTION ABOUT KEI IN 4884 02:50:55,262 --> 02:50:59,200 MY VIEW IS MORE OF A POLITICAL 4885 02:50:59,200 --> 02:50:59,633 ETIOLOGY. 4886 02:50:59,633 --> 02:51:02,937 JUST AS A POINT OF VIEW, AS 4887 02:51:02,937 --> 02:51:05,005 SHEPPARD OF THE NIH FUNDS, I 4888 02:51:05,005 --> 02:51:08,275 THINK MONEY PUT TO THAT WILL 4889 02:51:08,275 --> 02:51:10,711 HAVE LESS OF AN IMPACT OF THE 4890 02:51:10,711 --> 02:51:11,245 HEALTH AND WELL-BEING OF 4891 02:51:11,245 --> 02:51:13,214 AMERICANS, INCLUDING MINORITIES, 4892 02:51:13,214 --> 02:51:16,717 THAN MONEY PUT TO DIRECTLY 4893 02:51:16,717 --> 02:51:18,152 ASKING HOW CAN WE PREVENT 4894 02:51:18,152 --> 02:51:20,888 CHRONIC DISEASE, WHICH AFFLICTS 4895 02:51:20,888 --> 02:51:23,891 MINORITY AMERICANS AT HIGHER 4896 02:51:23,891 --> 02:51:30,764 LEVELS THAN MANY OTHERS. 4897 02:51:30,764 --> 02:51:32,366 SO I HOPE I ADDRESSED YOUR FIRST 4898 02:51:32,366 --> 02:51:33,267 QUESTION DIRECTLY. 4899 02:51:33,267 --> 02:51:35,503 AS FAR AS THE SECOND QUESTION, 4900 02:51:35,503 --> 02:51:37,972 YOU KNOW, THE MEANS OF 4901 02:51:37,972 --> 02:51:39,306 COMMUNICATION BETWEEN THE PUBLIC 4902 02:51:39,306 --> 02:51:41,709 AND SCIENTISTS, I MEAN, I THINK 4903 02:51:41,709 --> 02:51:45,212 IT'S JUST HARD BECAUSE WE'RE SO 4904 02:51:45,212 --> 02:51:47,781 USED TO TALKING TO THE PUBLIC IN 4905 02:51:47,781 --> 02:51:49,950 A CERTAIN WAY. 4906 02:51:49,950 --> 02:51:52,353 I REMEMBER WHEN I WAS A YOUNG 4907 02:51:52,353 --> 02:51:53,254 SCIENTIST, THE FIRST TIME 4908 02:51:53,254 --> 02:51:55,556 SOMEBODY APPROACHED ME AND ASKED 4909 02:51:55,556 --> 02:51:57,091 ME IF I'D WORK ON A PRESS 4910 02:51:57,091 --> 02:51:58,526 RELEASE, I THOUGHT TO MYSELF, 4911 02:51:58,526 --> 02:52:00,094 WHY IS THIS MY JOB, I SHOULDN'T 4912 02:52:00,094 --> 02:52:01,161 HAVE TO DO ANY OF THIS. 4913 02:52:01,161 --> 02:52:03,264 BUT I FOUND, THOUGH, IN THE LAST 4914 02:52:03,264 --> 02:52:05,132 FEW YEARS THAT INTERACTING 4915 02:52:05,132 --> 02:52:06,767 DIRECTLY WITH THE PUBLIC REALLY 4916 02:52:06,767 --> 02:52:08,969 DOES HELP -- IT SHARPENED MY 4917 02:52:08,969 --> 02:52:10,504 SCIENTIFIC IDEAS, IT HELPED 4918 02:52:10,504 --> 02:52:13,240 MESSY WHERE I FELL SHORT AS A 4919 02:52:13,240 --> 02:52:14,909 SCIENTIST IN COMMUNICATING, AND 4920 02:52:14,909 --> 02:52:16,844 I THINK IT'S ALTHOUGH SOMETIMES 4921 02:52:16,844 --> 02:52:17,845 BRUISING BECAUSE YOU HEAR THINGS 4922 02:52:17,845 --> 02:52:19,713 YOU DON'T WANT TO HEAR, IT'S 4923 02:52:19,713 --> 02:52:20,381 REALLY VITAL. 4924 02:52:20,381 --> 02:52:22,216 AND I DON'T KNOW, I'M GOING TO 4925 02:52:22,216 --> 02:52:24,952 TRY TO LEAD BY EXAMPLE ON THIS 4926 02:52:24,952 --> 02:52:28,455 AND JEAN, ANY SUGGESTIONS YOU 4927 02:52:28,455 --> 02:52:31,759 HAVE OR WORKING TOGETHER ON 4928 02:52:31,759 --> 02:52:32,960 THIS, I'D REALLY WELCOME. 4929 02:52:32,960 --> 02:52:34,395 IT ONE OF THESE THINGS THAT'S 4930 02:52:34,395 --> 02:52:35,729 GOING TO BE HARD BUT IS REALLY 4931 02:52:35,729 --> 02:52:36,830 ESSENTIAL IF WE'RE GOING TO 4932 02:52:36,830 --> 02:52:38,132 REGAIN THE TRUST OF THE AMERICAN 4933 02:52:38,132 --> 02:52:38,365 PEOPLE. 4934 02:52:38,365 --> 02:52:40,301 >> I'M REALLY HAPPY TO WORK ON 4935 02:52:40,301 --> 02:52:41,569 THIS, I THINK ABOUT IT ALL THE 4936 02:52:41,569 --> 02:52:41,769 TIME. 4937 02:52:41,769 --> 02:52:43,837 AND THE FIRST THING YOU SAID 4938 02:52:43,837 --> 02:52:45,372 ABOUT DEI, THANK YOU FOR SAYING 4939 02:52:45,372 --> 02:52:46,907 THAT. 4940 02:52:46,907 --> 02:52:49,910 I STILL THINK PROBABLY MASSIVE 4941 02:52:49,910 --> 02:52:50,778 MISUNDERSTANDING OF WHAT EXACTLY 4942 02:52:50,778 --> 02:52:53,213 IT MEANS AND IT DOESN'T MEAN. 4943 02:52:53,213 --> 02:52:56,383 >> WELL, JEAN, TO THE EXTENT 4944 02:52:56,383 --> 02:52:58,085 THAT -- THINGS THAT ADVANCE THE 4945 02:52:58,085 --> 02:53:00,654 HEALTH AND WELL-BEING OF PEOPLE, 4946 02:53:00,654 --> 02:53:03,657 THE NIH WILL SUPPORT IT. 4947 02:53:03,657 --> 02:53:06,727 THAT'S MY LITMUS LINE. 4948 02:53:06,727 --> 02:53:07,394 >> THANK YOU. 4949 02:53:07,394 --> 02:53:07,795 OKAY. 4950 02:53:07,795 --> 02:53:09,330 WE ARE GOING TO TAKE TWO MORE 4951 02:53:09,330 --> 02:53:11,432 QUESTIONS AND THEN I'M GOING TO 4952 02:53:11,432 --> 02:53:13,968 CUT THIS DISCUSSION TO A CLOSE 4953 02:53:13,968 --> 02:53:14,835 UNFORTUNATELY, ALTHOUGH I'M SURE 4954 02:53:14,835 --> 02:53:16,704 WE COULD ALL GO ALL DAY. 4955 02:53:16,704 --> 02:53:18,906 BUT I WANT TO BE RESPECTFUL OF 4956 02:53:18,906 --> 02:53:20,040 DR. BHATTACHARYA'S TIME AND OF 4957 02:53:20,040 --> 02:53:21,942 THE VERY FULL AGENDA THAT WE 4958 02:53:21,942 --> 02:53:22,743 HAVE FOR THE REST OF THE 4959 02:53:22,743 --> 02:53:23,544 AFTERNOON. 4960 02:53:23,544 --> 02:53:24,812 SO MONICA AND THEN LINDA, 4961 02:53:24,812 --> 02:53:25,045 PLEASE. 4962 02:53:25,045 --> 02:53:32,286 THANK YOU. 4963 02:53:32,286 --> 02:53:35,155 >> I THINK IT IS TREMENDOUSLY 4964 02:53:35,155 --> 02:53:36,357 REASSURING TO HEAR YOUR 4965 02:53:36,357 --> 02:53:37,691 PERSPECTIVE AS A LONG-STANDING 4966 02:53:37,691 --> 02:53:38,826 SCIENTIST AND AS SOMEONE WHO 4967 02:53:38,826 --> 02:53:39,460 CARES ABOUT THE HEALTH OF THE 4968 02:53:39,460 --> 02:53:40,427 AMERICAN PEOPLE. 4969 02:53:40,427 --> 02:53:42,296 AS AN INFECTIOUS DISEASE 4970 02:53:42,296 --> 02:53:43,397 RESEARCHER, IT'S HARD FOR ME NOT 4971 02:53:43,397 --> 02:53:46,266 TO BRING UP GLOBAL HEALTH 4972 02:53:46,266 --> 02:53:48,669 RESEARCH, AND THE REASON IS THAT 4973 02:53:48,669 --> 02:53:50,437 HIV IS A CHRONIC DISEASE. 4974 02:53:50,437 --> 02:53:55,175 CERTAINLY IN NO WAY DOES THE 4975 02:53:55,175 --> 02:53:57,478 ENTIRE BUDGET OF THE NIH GO 4976 02:53:57,478 --> 02:53:58,345 TOWARDS ACUTE DISEASES. 4977 02:53:58,345 --> 02:54:00,314 I THINK IT IS GENERALLY SKEWED 4978 02:54:00,314 --> 02:54:04,518 TOWARDS CHRONIC DISEASES, 4979 02:54:04,518 --> 02:54:05,686 INCLUDING THE CHRONIC DISEASES 4980 02:54:05,686 --> 02:54:07,621 IN INFECTIOUS DISEASE, WHICH ARE 4981 02:54:07,621 --> 02:54:10,290 HEPATITIS B AND HIV MOST 4982 02:54:10,290 --> 02:54:11,959 PROMINENTLY WITH AFTEREFFECTS 4983 02:54:11,959 --> 02:54:12,826 FROM TUBERCULOSIS. 4984 02:54:12,826 --> 02:54:15,029 SO DID WANT TO BRING UP YOUR 4985 02:54:15,029 --> 02:54:17,531 IDEAS ON GLOBAL HEALTH RESEARCH 4986 02:54:17,531 --> 02:54:21,468 AND THE TRANSLATION OF THAT WORK 4987 02:54:21,468 --> 02:54:23,671 THAT'S DONE IN PROMINENT PLACES 4988 02:54:23,671 --> 02:54:24,972 LIKE SOUTH AFRICA, WHICH 4989 02:54:24,972 --> 02:54:27,941 ABSOLUTELY HAS THE HIGHEST HIV 4990 02:54:27,941 --> 02:54:28,609 BURDEN, TO THE HEALTH OF 4991 02:54:28,609 --> 02:54:28,942 AMERICANS. 4992 02:54:28,942 --> 02:54:31,145 MOST OF THE WORK THAT IS LED TO 4993 02:54:31,145 --> 02:54:33,313 TREATMENT PARADIGMS TO 4994 02:54:33,313 --> 02:54:35,315 PREVENTION PARADIGMS, SCREEN FOR 4995 02:54:35,315 --> 02:54:36,250 RESISTANCE HAS BEEN DONE IN 4996 02:54:36,250 --> 02:54:38,352 GLOBAL SETTINGS, BUT ABSOLUTELY 4997 02:54:38,352 --> 02:54:39,019 BENEFITS AMERICANS BECAUSE 4998 02:54:39,019 --> 02:54:40,688 THAT'S HOW I KNOW HOW TO TREAT 4999 02:54:40,688 --> 02:54:42,890 HIV IS BECAUSE OF A BIG STUDY 5000 02:54:42,890 --> 02:54:43,957 DOWN IN SOUTH AFRICA. 5001 02:54:43,957 --> 02:54:46,060 SO WANTED TO ASK ABOUT -- AND 5002 02:54:46,060 --> 02:54:48,696 CERTAINLY THAT APPLIES TO AIR 5003 02:54:48,696 --> 02:54:51,632 POLLUTION TO CLASHES, TO 5004 02:54:51,632 --> 02:54:53,734 VIOLENCE, TO SO MANY OTHER 5005 02:54:53,734 --> 02:54:55,602 THAINGS MAY BE MORE HIGH 5006 02:54:55,602 --> 02:54:56,804 PREVALENCE IN A CERTAIN REGION 5007 02:54:56,804 --> 02:54:57,671 BUT BENEFIT AMERICANS. 5008 02:54:57,671 --> 02:54:59,673 SO THAT WAS MY QUESTION. 5009 02:54:59,673 --> 02:55:01,742 >> SO THANK YOU, MONICA, FOR 5010 02:55:01,742 --> 02:55:03,844 THAT. 5011 02:55:03,844 --> 02:55:07,014 I THINK THE PORTFOLIO -- THE NIH 5012 02:55:07,014 --> 02:55:09,950 HAS A LONG-STANDING RECORD OF 5013 02:55:09,950 --> 02:55:11,719 SUCCESS IN COLLABORATING IN 5014 02:55:11,719 --> 02:55:12,920 RESEARCH WITH OTHER COUNTRIES. 5015 02:55:12,920 --> 02:55:14,354 AND I THINK IT SHOULD CONTINUE 5016 02:55:14,354 --> 02:55:15,322 TO HAVE THAT. 5017 02:55:15,322 --> 02:55:20,728 THAT SAID, THERE ARE -- IT'S 5018 02:55:20,728 --> 02:55:22,062 INCUMBENT ON US TO ENSURE THAT 5019 02:55:22,062 --> 02:55:23,263 THAT PORTFOLIO REALLY DOES 5020 02:55:23,263 --> 02:55:25,566 TRANSLATE AND BENEFIT THE HEALTH 5021 02:55:25,566 --> 02:55:26,700 AND WELL-BEING OF THE AMERICAN 5022 02:55:26,700 --> 02:55:28,535 PEOPLE, WHICH IS OF COURSE THE 5023 02:55:28,535 --> 02:55:29,636 MISSION. 5024 02:55:29,636 --> 02:55:33,674 AND I THINK SPECIFICALLY FOR 5025 02:55:33,674 --> 02:55:34,942 HIV, THERE'S BEEN RECENT 5026 02:55:34,942 --> 02:55:36,643 ADVANCES WHICH I THINK OPEN UP, 5027 02:55:36,643 --> 02:55:44,051 FOR INSTANCE --CAPAVIR, YOU CAN 5028 02:55:44,051 --> 02:55:45,919 PREVENT HIV FOR ALMOST UP TO A 5029 02:55:45,919 --> 02:55:48,088 YEAR, I THINK. 5030 02:55:48,088 --> 02:55:48,522 REMARKABLE PRODUCT. 5031 02:55:48,522 --> 02:55:52,993 THAT OPENS UP NEW AREAS OF 5032 02:55:52,993 --> 02:55:53,761 POTENTIALLY THINKING ABOUT HOW 5033 02:55:53,761 --> 02:55:58,165 DO WE ERADICATE HIV FROM THIS 5034 02:55:58,165 --> 02:55:59,233 COUNTRY. 5035 02:55:59,233 --> 02:56:00,467 SO LOOKING AT THE PORTFOLIO OF 5036 02:56:00,467 --> 02:56:09,877 HIV INVESTMENTS, WE ALWAYS WANT 5037 02:56:09,877 --> 02:56:11,111 TO MAKE SURE WE ARE USING OUR 5038 02:56:11,111 --> 02:56:12,312 DOLLARS FOR THE MOST IMPORTANT 5039 02:56:12,312 --> 02:56:13,247 THINGS. 5040 02:56:13,247 --> 02:56:15,115 I'M NOT -- AND I'M AWARE AS 5041 02:56:15,115 --> 02:56:16,517 YOU'VE TOLD ME MANY TIMES, 5042 02:56:16,517 --> 02:56:17,417 MONICA, ABOUT THE IMPORTANCE OF 5043 02:56:17,417 --> 02:56:19,820 THE TRIAL NETWORKS IN SOUTH 5044 02:56:19,820 --> 02:56:21,155 AFRICA, FOR INSTANCE. 5045 02:56:21,155 --> 02:56:23,690 >> SORRY. 5046 02:56:23,690 --> 02:56:25,959 >> I APPRECIATE YOUR ADVICE ON 5047 02:56:25,959 --> 02:56:27,494 THAT ON ALL FRONTS. 5048 02:56:27,494 --> 02:56:29,263 BUT I DO THINK THAT LOOKING 5049 02:56:29,263 --> 02:56:30,998 CAREFULLY AT THIS PORTFOLIO IS 5050 02:56:30,998 --> 02:56:34,334 SOMETHING I INTEND TO DO, BUT 5051 02:56:34,334 --> 02:56:36,870 THE KEY TOUCH STONE WILL BE 5052 02:56:36,870 --> 02:56:39,807 LET'S MAKE INVESTMENTS THAT 5053 02:56:39,807 --> 02:56:42,342 ADVANCE THE HEALTH OF THE 5054 02:56:42,342 --> 02:56:43,844 AMERICAN PEOPLE, AND I 5055 02:56:43,844 --> 02:56:45,078 ANTICIPATE THAT THERE WILL BE 5056 02:56:45,078 --> 02:56:46,513 SOME CHANGES BUT I DON'T KNOW -- 5057 02:56:46,513 --> 02:56:48,048 I'M NOT -- I DON'T HAVE ANY 5058 02:56:48,048 --> 02:56:49,583 INTENTION TO STOP WORKING IN 5059 02:56:49,583 --> 02:56:51,051 FOREIGN COUNTRIES. 5060 02:56:51,051 --> 02:56:52,986 I THINK THAT WOULD ACTUALLY HARM 5061 02:56:52,986 --> 02:56:53,987 THE HEALTH AND WELL-BEING OF THE 5062 02:56:53,987 --> 02:56:54,421 AMERICAN PEOPLE. 5063 02:56:54,421 --> 02:56:56,523 SO I THINK WE CAN WORK TOGETHER 5064 02:56:56,523 --> 02:56:56,890 GOING FORWARD. 5065 02:56:56,890 --> 02:56:57,524 >> THANK YOU SO MUCH. 5066 02:56:57,524 --> 02:56:59,293 THANK YOU. 5067 02:56:59,293 --> 02:57:00,194 >> LINDA? 5068 02:57:00,194 --> 02:57:02,796 >> I'M LINDA CHANG. 5069 02:57:02,796 --> 02:57:04,731 I JUST HAVE A VERY -- THANK YOU 5070 02:57:04,731 --> 02:57:06,967 FIRST OF ALL FOR THAT WONDERFUL 5071 02:57:06,967 --> 02:57:09,603 OVERVIEW OF YOUR VISION OF NIH 5072 02:57:09,603 --> 02:57:11,538 AND I REALLY AGREE WITH ALL OF 5073 02:57:11,538 --> 02:57:12,973 YOUR POINTS. 5074 02:57:12,973 --> 02:57:15,475 I JUST DIDN'T HEAR A DISCUSSION 5075 02:57:15,475 --> 02:57:19,413 ABOUT WHETHER YOU HAVE PLANS ON 5076 02:57:19,413 --> 02:57:21,215 THE -- WE'VE BEEN HEARING ABOUT 5077 02:57:21,215 --> 02:57:22,749 THE NIH INSTITUTES ARE GOING TO 5078 02:57:22,749 --> 02:57:25,552 BE REORGANIZED AND WHETHER YOU 5079 02:57:25,552 --> 02:57:29,356 HAVE ANY SPECIFIC PLANS ALREADY 5080 02:57:29,356 --> 02:57:30,123 FOR THAT. 5081 02:57:30,123 --> 02:57:31,758 I'M JUST CURIOUS ABOUT THAT. 5082 02:57:31,758 --> 02:57:36,597 JUST A QUICK QUESTION. 5083 02:57:36,597 --> 02:57:37,464 >> THANK YOU, LINDA. 5084 02:57:37,464 --> 02:57:38,799 I DON'T HAVE ANY SPECIFIC PLANS 5085 02:57:38,799 --> 02:57:39,867 FOR REORGANIZATION AT THE 5086 02:57:39,867 --> 02:57:40,234 MOMENT. 5087 02:57:40,234 --> 02:57:41,535 I'VE TALKED WITH MEMBERS OF 5088 02:57:41,535 --> 02:57:42,269 CONGRESS WHO HAVE PLANS. 5089 02:57:42,269 --> 02:57:48,208 I THINK THE OMB HAD A PLAN, I'VE 5090 02:57:48,208 --> 02:57:49,543 ALSO READ ALL THE DOCUMENTS 5091 02:57:49,543 --> 02:57:50,978 GOING BACK DECADES ON 5092 02:57:50,978 --> 02:57:51,812 REORGANIZATION IDEAS FOR THE 5093 02:57:51,812 --> 02:57:52,946 NIH. 5094 02:57:52,946 --> 02:57:54,815 I'M GOING TO WORK WITH THE 5095 02:57:54,815 --> 02:57:55,649 ADMINISTRATION AND WITH CONGRESS 5096 02:57:55,649 --> 02:57:56,216 ON THIS. 5097 02:57:56,216 --> 02:57:58,785 I'M NOT PLANNING TO GO ROGUE ON 5098 02:57:58,785 --> 02:58:00,454 IT MYSELF. 5099 02:58:00,454 --> 02:58:02,189 I THINK ANY REORGANIZATION IS 5100 02:58:02,189 --> 02:58:04,258 GOING TO HAVE TO THINK THROUGH 5101 02:58:04,258 --> 02:58:05,626 CAREFULLY WHAT WILL BE GAINED 5102 02:58:05,626 --> 02:58:06,260 FROM IT. 5103 02:58:06,260 --> 02:58:07,694 IF IT'S JUST REORGANIZATION FOR 5104 02:58:07,694 --> 02:58:09,229 ITS OWN SAKE, IT WON'T MAKE ANY 5105 02:58:09,229 --> 02:58:12,432 SENSE, BUT IF IT REALLY DOES 5106 02:58:12,432 --> 02:58:13,634 RESULT IN COLLABORATIONS THAT 5107 02:58:13,634 --> 02:58:17,671 WOULD NOT HAVE OCCURRED, 5108 02:58:17,671 --> 02:58:19,206 REDUCTIONS IN DUPLICATION OF 5109 02:58:19,206 --> 02:58:24,945 EFFORTS THAT DON'T ACTUALLY -- 5110 02:58:24,945 --> 02:58:26,446 THINGS LIKE THAT, THEN IT MIGHT 5111 02:58:26,446 --> 02:58:27,214 MAKE SENSE TO DO IT. 5112 02:58:27,214 --> 02:58:28,749 BUT I'M GOING TO RELY VERY 5113 02:58:28,749 --> 02:58:30,183 HEAVILY ON ADVICE. 5114 02:58:30,183 --> 02:58:32,486 THERE'S AN SMRB PROCESS THAT 5115 02:58:32,486 --> 02:58:34,121 CONGRESS ACTUALLY PUT IN PLACE 5116 02:58:34,121 --> 02:58:36,423 FOR THIS EXACT PROCESS. 5117 02:58:36,423 --> 02:58:37,524 SO I'M THINKING ABOUT MAYBE 5118 02:58:37,524 --> 02:58:38,825 USING THAT IF THERE REALLY IS A 5119 02:58:38,825 --> 02:58:40,394 LOT OF DESIRE IN CONGRESS TO DO 5120 02:58:40,394 --> 02:58:42,296 THIS REORGANIZATION. 5121 02:58:42,296 --> 02:58:44,464 I'M NOT PLANNING ON DOING 5122 02:58:44,464 --> 02:58:45,799 ANYTHING HALF BAKED ON THIS. 5123 02:58:45,799 --> 02:58:47,868 >> SO YOU DON'T SEE THIS 5124 02:58:47,868 --> 02:58:50,237 HAPPENING IN THE VERY NEAR 5125 02:58:50,237 --> 02:58:50,537 FUTURE? 5126 02:58:50,537 --> 02:58:52,172 BECAUSE THERE WERE RUMORS THAT 5127 02:58:52,172 --> 02:58:54,174 THEY WERE GOING TO DECREASE THE 5128 02:58:54,174 --> 02:58:56,209 NUMBER OF INSTITUTES DOWN TO 5129 02:58:56,209 --> 02:58:58,679 EIGHT INSTITUTES OR SOMETHING 5130 02:58:58,679 --> 02:59:00,047 LIKE THAT, SOMETHING DRASTIC. 5131 02:59:00,047 --> 02:59:01,315 >> I THINK THERE WAS A LEAK OF 5132 02:59:01,315 --> 02:59:02,849 THE OMB MEMO. 5133 02:59:02,849 --> 02:59:05,352 >> YEAH. 5134 02:59:05,352 --> 02:59:07,020 >> BUT AGAIN, LIN DA THAT WAS 5135 02:59:07,020 --> 02:59:08,922 THE BEGINNING OF A NEGOTIATION. 5136 02:59:08,922 --> 02:59:09,690 I DON'T KNOW. 5137 02:59:09,690 --> 02:59:12,426 WE'LL SEE WHAT THE END POINT IS. 5138 02:59:12,426 --> 02:59:14,394 I PERSONALLY HAVE NO PLANS TO DO 5139 02:59:14,394 --> 02:59:15,762 ANYTHING WITHOUT LOTS OF ADVICE. 5140 02:59:15,762 --> 02:59:16,496 >> OKAY. 5141 02:59:16,496 --> 02:59:20,667 THANK YOU. 5142 02:59:20,667 --> 02:59:22,102 >> OKAY, GREAT. 5143 02:59:22,102 --> 02:59:24,604 THANK YOU ALL FOR SUCH A ROBUST 5144 02:59:24,604 --> 02:59:25,839 DISCUSSION AND THANK YOU SO 5145 02:59:25,839 --> 02:59:29,009 MUCH, JAY, FOR YOUR REMARKS, 5146 02:59:29,009 --> 02:59:31,511 BOTH YOUR PRESENTATION AND YOUR 5147 02:59:31,511 --> 02:59:33,480 THOUGHTFUL CONSIDERATION OF THE 5148 02:59:33,480 --> 02:59:35,282 QUESTIONS POSED TO YOU BY 5149 02:59:35,282 --> 02:59:36,817 COUNCILMEMBERS AND FOR SPENDING 5150 02:59:36,817 --> 02:59:37,684 SOME EXTRA TIME WITH US. 5151 02:59:37,684 --> 02:59:39,086 I KNOW YOU HAVE A VERY BUSY 5152 02:59:39,086 --> 02:59:41,054 SCHEDULE, SO THANK YOU FOR THAT. 5153 02:59:41,054 --> 02:59:41,254 OKAY. 5154 02:59:41,254 --> 02:59:41,688 >> THANK YOU. 5155 02:59:41,688 --> 02:59:44,791 >> WE ARE NOW GOING TO MOVE ON 5156 02:59:44,791 --> 02:59:48,295 TO THE NEXT PRESENTATION, WHICH 5157 02:59:48,295 --> 02:59:49,830 IS FROM MARINA VOLKOV ON THE 5158 02:59:49,830 --> 02:59:51,932 COUNCIL OF COUNCILS' WORKING 5159 02:59:51,932 --> 02:59:54,034 GROUP ON SCIENCE OF SCIENCE. 5160 02:59:54,034 --> 02:59:56,737 SHE IS THE DIRECTOR OF DPCPSI'S 5161 02:59:56,737 --> 03:00:00,474 OFFICE OF EVALUATION, 5162 03:00:00,474 --> 03:00:01,308 PERFORMANCE AND REPORTING. 5163 03:00:01,308 --> 03:00:03,276 SO NIH HAS A LONG HISTORY OF 5164 03:00:03,276 --> 03:00:05,145 ENGAGING WITH RESEARCHERS TO 5165 03:00:05,145 --> 03:00:07,347 GENERATE EVIDENCE TO INFORM 5166 03:00:07,347 --> 03:00:09,216 IMPROVEMENTS TO ITS PROGRAMS, 5167 03:00:09,216 --> 03:00:10,417 POLICIES AND PROCESSES. 5168 03:00:10,417 --> 03:00:12,486 THE SCIENCE OF SCIENCE ALSO 5169 03:00:12,486 --> 03:00:15,489 KNOWN AS META SCIENCE IS 5170 03:00:15,489 --> 03:00:16,690 ABSOLUTELY CRUCIAL FOR 5171 03:00:16,690 --> 03:00:17,791 UNDERSTANDING THESE PROCESSES 5172 03:00:17,791 --> 03:00:19,826 AND THAT SHAPE SCIENTIFIC 5173 03:00:19,826 --> 03:00:20,827 DISCOVERY AND A INNOVATION. 5174 03:00:20,827 --> 03:00:22,796 SO BY ANALYZING PATTERNS AND 5175 03:00:22,796 --> 03:00:24,231 FUNDING COLLABORATION, 5176 03:00:24,231 --> 03:00:26,099 PUBLICATION AND REPRODUCIBILITY, 5177 03:00:26,099 --> 03:00:28,535 THIS FIELD CAN REALLY HELP 5178 03:00:28,535 --> 03:00:31,038 OPTIMIZE RESEARCH PRACTICES AND 5179 03:00:31,038 --> 03:00:32,606 IMPROVE RESOURCE ALLOCATION, 5180 03:00:32,606 --> 03:00:34,674 PARTICULARLY IN A CONSTRAINED 5181 03:00:34,674 --> 03:00:37,310 ENVIRONMENT, AND ENHANCE OUR 5182 03:00:37,310 --> 03:00:41,281 SCIENTIFIC IMPACT OVERALL. 5183 03:00:41,281 --> 03:00:44,484 ULTIMATELY IT THIS REALLY 5184 03:00:44,484 --> 03:00:45,552 STRENGTHENING -- APPLYING 5185 03:00:45,552 --> 03:00:46,653 SCIENTIFIC PRINCIPLES TO HELP US 5186 03:00:46,653 --> 03:00:48,121 UNDERSTAND HOW TO BETTER SUPPORT 5187 03:00:48,121 --> 03:00:50,424 AND SHAPE SCIENCE IS REALLY A 5188 03:00:50,424 --> 03:00:52,292 CRUCIAL ROLE FOR DPCPSI. 5189 03:00:52,292 --> 03:00:54,694 SO WE RECENTLY SOLICITED 5190 03:00:54,694 --> 03:00:56,329 APPLICATIONS FOR A PILOT SCIENCE 5191 03:00:56,329 --> 03:00:58,865 OF SCIENCE SCHOLARS PROGRAM THAT 5192 03:00:58,865 --> 03:01:02,469 WILL BRING EXPERTS IN THE 5193 03:01:02,469 --> 03:01:05,038 SCIENCE OF SCIENCE TO HELP 5194 03:01:05,038 --> 03:01:05,906 ANSWER CRITICALLY IMPORTANT 5195 03:01:05,906 --> 03:01:07,874 QUESTIONS TO IMPROVE NIH 5196 03:01:07,874 --> 03:01:08,642 PROCESSES, POLICIES AND 5197 03:01:08,642 --> 03:01:09,676 PROGRAMS, BUT THERE IS MORE THAT 5198 03:01:09,676 --> 03:01:10,343 WE CAN DO. 5199 03:01:10,343 --> 03:01:13,647 WE THINK THIS DESERVES FURTHER 5200 03:01:13,647 --> 03:01:15,482 BROAD CONSIDERATION, SO THAT'S 5201 03:01:15,482 --> 03:01:16,850 BUILT INTO A PROPOSAL WE HAVE 5202 03:01:16,850 --> 03:01:18,585 AND THAT I WOULD APPRECIATE YOUR 5203 03:01:18,585 --> 03:01:19,486 FEEDBACK ON. 5204 03:01:19,486 --> 03:01:21,021 SO MARINA, I'LL TURN IT OVER TO 5205 03:01:21,021 --> 03:01:21,521 YOU NOW. 5206 03:01:21,521 --> 03:01:23,757 >> NICOLE, THANK YOU VERY MUCH. 5207 03:01:23,757 --> 03:01:25,292 AND I APPRECIATE THAT 5208 03:01:25,292 --> 03:01:25,725 INTRODUCTION. 5209 03:01:25,725 --> 03:01:28,261 IT'S ACTUALLY -- THAT WAS GREAT 5210 03:01:28,261 --> 03:01:29,663 COVERAGE AND I'M GOING TO SEE IF 5211 03:01:29,663 --> 03:01:32,232 I CAN MAKE UP SOME SIGNIFICANT 5212 03:01:32,232 --> 03:01:34,434 TIME FOR YOU ALL BECAUSE NICOLE 5213 03:01:34,434 --> 03:01:36,069 REALLY LAID OUT WHAT IT IS THAT 5214 03:01:36,069 --> 03:01:37,737 I'M HERE TO DISCUSS, SO I CAN 5215 03:01:37,737 --> 03:01:38,939 SKIP THROUGH. 5216 03:01:38,939 --> 03:01:41,441 SO WITH THAT, IF WE CAN GO TO 5217 03:01:41,441 --> 03:01:44,644 THE NEXT SLIDE, PLEASE. 5218 03:01:44,644 --> 03:01:47,080 AS NICOLE MENTIONED, THERE IS 5219 03:01:47,080 --> 03:01:49,149 THIS VERY ROBUST 5220 03:01:49,149 --> 03:01:49,816 INTERDISCIPLINARY FIELD OF THE 5221 03:01:49,816 --> 03:01:52,686 SCIENCE OF SCIENCE OR META 5222 03:01:52,686 --> 03:01:53,653 SCIENCE. 5223 03:01:53,653 --> 03:01:56,056 ALSO WHERE PEOPLE TRULY ARE 5224 03:01:56,056 --> 03:01:59,126 STUDYING THE SCIENTIFIC PROCESS 5225 03:01:59,126 --> 03:02:02,229 ITSELF, AND WHAT I'M HERE TO 5226 03:02:02,229 --> 03:02:04,965 TALK ABOUT TODAY SL HOW WE CAN 5227 03:02:04,965 --> 03:02:08,702 BRING THAT KIND OF ROBUST 5228 03:02:08,702 --> 03:02:12,839 SCIENTIFIC INQUIRY IN TO NIH TO 5229 03:02:12,839 --> 03:02:13,874 ANSWER MANY OF THE QUESTIONS OR 5230 03:02:13,874 --> 03:02:14,975 TO BEGIN TO ANSWER MANY OF THE 5231 03:02:14,975 --> 03:02:15,842 QUESTIONS THAT HAVE BEEN 5232 03:02:15,842 --> 03:02:17,144 DISCUSSED THROUGHOUT THE DAY 5233 03:02:17,144 --> 03:02:17,477 TODAY. 5234 03:02:17,477 --> 03:02:20,380 AND I FEEL AS THOUGH THE WHOLE 5235 03:02:20,380 --> 03:02:22,449 CONVERSATION THAT WE HAD THIS 5236 03:02:22,449 --> 03:02:23,950 MORNING, WITH DR. BHATTACHARYA 5237 03:02:23,950 --> 03:02:25,952 JUST NOW, REALLY BEGS THE 5238 03:02:25,952 --> 03:02:30,590 QUESTION OF HOW CAN NIH BETTER 5239 03:02:30,590 --> 03:02:32,993 UNDERSTAND HOW THE THAINGS WE DO 5240 03:02:32,993 --> 03:02:34,728 ARE MEETING OUR MISSION AND HOW 5241 03:02:34,728 --> 03:02:36,129 CAN WE IMPROVE UPON THAT. 5242 03:02:36,129 --> 03:02:37,430 SO THAT'S REALLY THE CRUX OF 5243 03:02:37,430 --> 03:02:43,236 WHAT WE'RE TALKING ABOUT. 5244 03:02:43,236 --> 03:02:44,538 AND AGAIN, I'M NOT GOING TO GO 5245 03:02:44,538 --> 03:02:45,338 THROUGH THIS BECAUSE I THINK 5246 03:02:45,338 --> 03:02:47,307 THIS IS REALLY WHAT WE'VE BEEN 5247 03:02:47,307 --> 03:02:48,041 DISCUSSING THROUGHOUT MUCH OF 5248 03:02:48,041 --> 03:02:49,843 THE DAY. 5249 03:02:49,843 --> 03:02:52,846 I WANT TO POINT OUT THIS IS A 5250 03:02:52,846 --> 03:02:53,947 QUESTION NIH HAS BEEN GRAPPLING 5251 03:02:53,947 --> 03:02:55,482 WITH FOR SOME TIME. 5252 03:02:55,482 --> 03:02:57,984 BACK IN 2014, THE SCIENTIFIC 5253 03:02:57,984 --> 03:03:00,353 MANAGEMENT REVIEW BOARD, THE 5254 03:03:00,353 --> 03:03:02,956 SMRB PUBLISHED A REPORT IN WHICH 5255 03:03:02,956 --> 03:03:06,626 IT RECOMMENDED THAT NIH HAVE A 5256 03:03:06,626 --> 03:03:10,664 SYSTEMATIC AND COMPREHENSIVE 5257 03:03:10,664 --> 03:03:12,399 APPROACH TOWARDS STUDYING 5258 03:03:12,399 --> 03:03:12,799 ITSELF. 5259 03:03:12,799 --> 03:03:17,103 WE HAVE BEEN WORKING STEADILY ON 5260 03:03:17,103 --> 03:03:19,139 THIS SYSTEMATIC AND 5261 03:03:19,139 --> 03:03:20,774 COMPREHENSIVE APPROACH, AND IF I 5262 03:03:20,774 --> 03:03:24,744 CAN GO TO THE NEXT, MANY 5263 03:03:24,744 --> 03:03:26,346 EXTERNAL FOLKS HAVE BEEN SAYING 5264 03:03:26,346 --> 03:03:30,183 THE SAME THING. 5265 03:03:30,183 --> 03:03:31,484 ONE THING THAT IS OF GREAT 5266 03:03:31,484 --> 03:03:33,687 IMPORTANCE, SO IN THE SCIENCE OF 5267 03:03:33,687 --> 03:03:35,355 SCIENCE FIELD, BY BRINGING 5268 03:03:35,355 --> 03:03:36,656 EXTERNAL PEOPLE IN TO HELP US 5269 03:03:36,656 --> 03:03:40,160 BETTER ANSWER THESE QUESTIONS, 5270 03:03:40,160 --> 03:03:42,729 ONE DID CONNECT THAT HAS ALWAYS 5271 03:03:42,729 --> 03:03:45,565 EXISTED BETWEEN THE PEOPLE IN 5272 03:03:45,565 --> 03:03:46,666 THE EXTERNAL WORLD AND THOSE OF 5273 03:03:46,666 --> 03:03:48,068 US WORKING WITHIN IS THERE'S 5274 03:03:48,068 --> 03:03:54,674 ALWAYS BEEN A BIT O IN TERMS OF 5275 03:03:54,674 --> 03:03:57,210 THE QUESTIONS OF PEOPLE EXTERNAL 5276 03:03:57,210 --> 03:03:59,813 TO US VOARS US THOSE INTERNAL, 5277 03:03:59,813 --> 03:04:06,987 AND HE QUESTIONS OF -- NIH IS A 5278 03:04:06,987 --> 03:04:11,691 VERY BYZANTINE PLACE, WE HAVE 5279 03:04:11,691 --> 03:04:12,726 DATA, WE DID NOT MAKE IT 5280 03:04:12,726 --> 03:04:13,827 AVAILABLE TO EVERYONE BECAUSE IT 5281 03:04:13,827 --> 03:04:15,262 IS ALSO PROPRIETARY DATA. 5282 03:04:15,262 --> 03:04:16,363 EARLIER TODAY, WHEN TALKING 5283 03:04:16,363 --> 03:04:18,598 ABOUT HRHR, THE QUESTION CAME UP 5284 03:04:18,598 --> 03:04:21,568 OF LOOKING AT THOSE -- OF THOSE 5285 03:04:21,568 --> 03:04:23,103 UNFUNDED APPLICATIONS. 5286 03:04:23,103 --> 03:04:25,572 THAT IS JUST ONE EXAMPLE OF 5287 03:04:25,572 --> 03:04:27,407 PROPRIETARY DATA THAT WE CANNOT 5288 03:04:27,407 --> 03:04:29,709 SHARE OUTSIDE OF THE NIH 5289 03:04:29,709 --> 03:04:30,910 FIREWALL, WHICH HAS ALWAYS BEEN 5290 03:04:30,910 --> 03:04:32,646 A FRUSTRATION TO THE PEOPLE WHO 5291 03:04:32,646 --> 03:04:34,080 ACTUALLY STUDY US. 5292 03:04:34,080 --> 03:04:35,715 ACTUALLY IF WE CAN GO TO THE 5293 03:04:35,715 --> 03:04:37,751 NEXT SLIDE, I'M GOING TO SKIP 5294 03:04:37,751 --> 03:04:40,153 OVER SOME OF THESE FACTORS. 5295 03:04:40,153 --> 03:04:42,989 SO AGAIN, MANY, MANY RESEARCHERS 5296 03:04:42,989 --> 03:04:44,357 HAVE BEEN STUDYING US FROM 5297 03:04:44,357 --> 03:04:46,026 OUTSIDE OF NIH AND WANT TO POINT 5298 03:04:46,026 --> 03:04:47,427 OUT IN THE MIDDLE OF THIS, THIS 5299 03:04:47,427 --> 03:04:49,763 IS JUST A HANDFUL OF EXAMPLES OF 5300 03:04:49,763 --> 03:04:50,830 IMPORTANT STUDIES. 5301 03:04:50,830 --> 03:04:54,267 YOU'LL SEE DR. BHATTACHARYA, HE 5302 03:04:54,267 --> 03:04:56,503 REFERENCED THIS STUDY THAT HE 5303 03:04:56,503 --> 03:04:58,371 PUBLISHED ON DOES NIH FUND EDGE 5304 03:04:58,371 --> 03:05:00,340 SCIENCE, SO HE HAS BEEN WORKING 5305 03:05:00,340 --> 03:05:05,011 IN THE SCIENCE OF SCIENCE AREA. 5306 03:05:05,011 --> 03:05:06,746 I ALSO WANT TO POINT OUT TO THE 5307 03:05:06,746 --> 03:05:08,948 LEFT, THE RACE/ETHNICITY AND NIH 5308 03:05:08,948 --> 03:05:10,717 RESEARCH AWARDS IS A PAPER THAT 5309 03:05:10,717 --> 03:05:12,919 CAME OUT IN 2011 BY DONNA 5310 03:05:12,919 --> 03:05:13,687 GINTHER AND COLLEAGUES AND I 5311 03:05:13,687 --> 03:05:16,623 JUST WANT TO MENTION THIS PAPER 5312 03:05:16,623 --> 03:05:18,658 IN PARTICULAR BECAUSE FOLKS HAVE 5313 03:05:18,658 --> 03:05:20,093 BEEN REFERRING TO THIS FOR YEARS 5314 03:05:20,093 --> 03:05:22,395 AND YEARS AT NIH AS THE GINTHER 5315 03:05:22,395 --> 03:05:24,564 EFFECT. 5316 03:05:24,564 --> 03:05:28,134 IT HAD REAL IMPACT IN HOW NIH 5317 03:05:28,134 --> 03:05:29,803 APPROACHED SUPPORT OF THE 5318 03:05:29,803 --> 03:05:32,205 RESEARCH COMMUNITY AND WE NEED 5319 03:05:32,205 --> 03:05:33,940 MORE WORK SUCH AS THE GINTHER 5320 03:05:33,940 --> 03:05:37,610 PAPER TO REALLY HELP US 5321 03:05:37,610 --> 03:05:39,012 UNDERSTAND WHAT WE'RE DOING HOW 5322 03:05:39,012 --> 03:05:40,113 WE CAN DO IT BETTER. 5323 03:05:40,113 --> 03:05:43,717 SO WITH THAT NEXT SLIDE. 5324 03:05:43,717 --> 03:05:45,285 SO THIS SCIENTIFIC FIELD, THE 5325 03:05:45,285 --> 03:05:46,720 SCIENCE OF SCIENCE FIELD IS 5326 03:05:46,720 --> 03:05:51,524 PRIMARILY FUNDED THROUGH -- FOR 5327 03:05:51,524 --> 03:05:52,859 PUBLIC FUNDS THROUGH THE 5328 03:05:52,859 --> 03:05:53,660 NATIONAL SCIENCE FOUNDATION. 5329 03:05:53,660 --> 03:05:58,365 BACK IN 2006, THEY BEGAN A 5330 03:05:58,365 --> 03:06:02,001 PROGRAM KNOWN AS THE SCIENCE OF 5331 03:06:02,001 --> 03:06:05,004 SCIENCE AND INNOVATION POLICY, 5332 03:06:05,004 --> 03:06:06,773 SCISIP. 5333 03:06:06,773 --> 03:06:08,541 THE NAME HAS CHANGED BUT THE 5334 03:06:08,541 --> 03:06:10,143 POINT REMAINS THE SAME, WHAT 5335 03:06:10,143 --> 03:06:11,511 EVIDENCE CAN BE GENERATED BY THE 5336 03:06:11,511 --> 03:06:13,046 SCIENTIFIC FIELD THAT CAN HELP 5337 03:06:13,046 --> 03:06:14,381 POLICYMAKERS IN IMPROVING UPON 5338 03:06:14,381 --> 03:06:16,816 WHAT WE DO. 5339 03:06:16,816 --> 03:06:18,551 SO THIS WHOLE IDEA OF THIS 5340 03:06:18,551 --> 03:06:21,788 PROGRAM WAS TO REALLY CREATE AN 5341 03:06:21,788 --> 03:06:23,323 EVIDENCE-BASE FOR POLICYMAKERS 5342 03:06:23,323 --> 03:06:27,794 IN MAKING DECISIONS ON HOW BEST 5343 03:06:27,794 --> 03:06:32,899 TO CONDUCT SCIENTIFIC RESEARCH. 5344 03:06:32,899 --> 03:06:35,635 SO BACK IN 2019, OUR NATIONAL 5345 03:06:35,635 --> 03:06:37,337 INSTITUTE OF GENERAL MEDICAL 5346 03:06:37,337 --> 03:06:42,509 SCIENCES PARTNERED WITH THIS 5347 03:06:42,509 --> 03:06:43,910 PROGRAM TO CREATE A SUBSET OF 5348 03:06:43,910 --> 03:06:45,011 THE PROGRAM AND TO REALLY 5349 03:06:45,011 --> 03:06:48,381 SUPPORT THOSE STUDIES THAT COULD 5350 03:06:48,381 --> 03:06:50,316 EXAMINE IMPORTANT ASPECTS OF THE 5351 03:06:50,316 --> 03:06:52,419 BIOMEDICAL RESEARCH ENTERPRISE. 5352 03:06:52,419 --> 03:06:56,656 SO SCIENCE OF SCIENCE BIO HAS 5353 03:06:56,656 --> 03:06:57,657 EXISTED SINCE 2019. 5354 03:06:57,657 --> 03:06:58,591 IT'S AN INTERESTING PROGRAM 5355 03:06:58,591 --> 03:07:01,661 BECAUSE IT IS TRULY CONDUCTED IN 5356 03:07:01,661 --> 03:07:04,130 PARTNERSHIP WITH NSF AND THE 5357 03:07:04,130 --> 03:07:07,934 REVIEW, THE MANAGEMENT OF THE -- 5358 03:07:07,934 --> 03:07:12,205 THE REVIEW ASPECTS, THAT IS 5359 03:07:12,205 --> 03:07:13,973 HANDLED BY NSF AND THEN THE 5360 03:07:13,973 --> 03:07:16,876 FUNDING IS DONE BY N IGMS AND 5361 03:07:16,876 --> 03:07:17,844 THE MANAGEMENT OF THE GRANTS 5362 03:07:17,844 --> 03:07:18,311 MOVING FORWARD. 5363 03:07:18,311 --> 03:07:19,612 I WANTED TO GIVE YOU JUST A 5364 03:07:19,612 --> 03:07:20,613 HANDFUL OF EXAMPLES WITH THE 5365 03:07:20,613 --> 03:07:25,185 NEXT SLIDE, PLEASE. 5366 03:07:25,185 --> 03:07:26,653 AGAIN THESE ARE JUST A FEW 5367 03:07:26,653 --> 03:07:28,421 EXAMPLES OF THINGS THAT ARE 5368 03:07:28,421 --> 03:07:30,623 BEING STUDIED WITHIN THAT. 5369 03:07:30,623 --> 03:07:33,927 YOU CAN SEE THAT THESE GRANTS 5370 03:07:33,927 --> 03:07:36,796 CAN LOOK OR THESE GRANT PROJECTS 5371 03:07:36,796 --> 03:07:39,399 WILL LOOK AT THE IMPACT OF NIH 5372 03:07:39,399 --> 03:07:41,100 POLICIES ON THE CONDUCT OF 5373 03:07:41,100 --> 03:07:42,902 SCIENCE. 5374 03:07:42,902 --> 03:07:45,205 THERE ARE GRANTS TO LOOK AT THE 5375 03:07:45,205 --> 03:07:48,475 SUPPORT FOR RESOURCES AND 5376 03:07:48,475 --> 03:07:49,509 METHODOLOGY DEVELOPMENT, WHAT IS 5377 03:07:49,509 --> 03:07:51,044 THE IMPACT OF THOSE PROGRAMS. 5378 03:07:51,044 --> 03:07:53,112 THERE ARE STUDIES TO LOOK AT THE 5379 03:07:53,112 --> 03:07:55,281 WORKFORCE AND HOW WE SUPPORT THE 5380 03:07:55,281 --> 03:07:59,552 WORKFORCE, WHAT IS THE BEST WAY 5381 03:07:59,552 --> 03:08:00,753 OF GOING ABOUT MAINTAINING THE 5382 03:08:00,753 --> 03:08:02,489 PIPELINE OF RESEARCHERS, AND 5383 03:08:02,489 --> 03:08:04,757 THERE ARE STUDIES ON DATA 5384 03:08:04,757 --> 03:08:06,292 SHARING AND THE IMPACT OF DATA 5385 03:08:06,292 --> 03:08:07,393 SHARING AND WHAT IT MEANS FOR 5386 03:08:07,393 --> 03:08:07,794 SCIENCE. 5387 03:08:07,794 --> 03:08:09,762 THIS IS JUST EXAMPLES OF THE 5388 03:08:09,762 --> 03:08:11,731 TYPE OF PROJECTS THAT ARE FUNDED 5389 03:08:11,731 --> 03:08:12,932 WITHIN THIS. 5390 03:08:12,932 --> 03:08:15,101 IN ADDITION TO THIS GRANT 5391 03:08:15,101 --> 03:08:16,369 PROGRAM, IF WE CAN GO TO THE 5392 03:08:16,369 --> 03:08:23,142 NEXT SLIDE, PLEASE, WE HAVE MANY 5393 03:08:23,142 --> 03:08:24,711 DIFFERENT WAYS IN WHICH WE HAVE 5394 03:08:24,711 --> 03:08:26,279 BEEN ENGAGING WITH THE SCIENCE 5395 03:08:26,279 --> 03:08:28,047 OF SCIENCE RESEARCH COMMUNITY. 5396 03:08:28,047 --> 03:08:29,482 WE'VE HAD SEVERAL MEETINGS, THIS 5397 03:08:29,482 --> 03:08:30,850 IS JUST LISTING A HANDFUL OF 5398 03:08:30,850 --> 03:08:32,385 THEM, WHERE WE TRY TO BRING 5399 03:08:32,385 --> 03:08:34,554 TOGETHER AGAIN THE NIH 5400 03:08:34,554 --> 03:08:37,390 POLICYMAKERS, THE NIH PROGRAM 5401 03:08:37,390 --> 03:08:40,860 FOLKS TO WORK CLOSELY WITH THIS 5402 03:08:40,860 --> 03:08:43,696 RESEARCH COMMUNITY TO HELP 5403 03:08:43,696 --> 03:08:45,899 CREATE THAT HANDSHAKE WHERE THE 5404 03:08:45,899 --> 03:08:49,235 QUESTIONS OF INTEREST ALIGN TO 5405 03:08:49,235 --> 03:08:51,104 IDENTIFY THOSE, AND ALONG THOSE 5406 03:08:51,104 --> 03:08:54,274 LINES, WE PARTICIPATED LAST YEAR 5407 03:08:54,274 --> 03:08:57,410 IN SOMETHING WITH OMB. 5408 03:08:57,410 --> 03:08:59,612 OMB, AND I DIDN'T GO INTO IT 5409 03:08:59,612 --> 03:09:02,348 THERE, THE EVIDENCE ACT OF THE 5410 03:09:02,348 --> 03:09:04,317 FOUNDATIONS OF EVIDENCE-BASED 5411 03:09:04,317 --> 03:09:05,485 POLICYMAKING ACT KNOWN AS THE 5412 03:09:05,485 --> 03:09:07,921 EVIDENCE ACT WAS PASSED IF 2018, 5413 03:09:07,921 --> 03:09:09,789 AS PART OF THE IMPLEMENTATION OF 5414 03:09:09,789 --> 03:09:13,660 THAT ACT, OMB IS TRYING TO 5415 03:09:13,660 --> 03:09:15,061 CREATE OPPORTUNITIES FOR 5416 03:09:15,061 --> 03:09:18,898 HANDSHAKES BETWEEN FEDERAL 5417 03:09:18,898 --> 03:09:19,732 DEPARTMENTS AND THE RESEARCH 5418 03:09:19,732 --> 03:09:20,867 COMMUNITY AND WE PARTICIPATED IN 5419 03:09:20,867 --> 03:09:24,037 THAT WHERE WE WERE ABLE TO 5420 03:09:24,037 --> 03:09:27,106 PUBLISH ON THE OMB PORTAL WHAT 5421 03:09:27,106 --> 03:09:28,274 ARE THE QUESTIONS OF GREATEST 5422 03:09:28,274 --> 03:09:30,009 INTEREST TO NIH THAT WE WOULD 5423 03:09:30,009 --> 03:09:31,344 HOPE THAT THOSE EXTERNAL TO US 5424 03:09:31,344 --> 03:09:34,714 WOULD STUDY ABOUT US, AND THAT 5425 03:09:34,714 --> 03:09:36,883 GENERATED A LOT OF INTEREST, A 5426 03:09:36,883 --> 03:09:38,217 LOT OF INTERESTING CONVERSATIONS 5427 03:09:38,217 --> 03:09:40,386 AND HOPEFULLY AT SOME POINT A 5428 03:09:40,386 --> 03:09:42,789 LOT OF VERY INTERESTING RESEARCH 5429 03:09:42,789 --> 03:09:44,524 RESULTS THAT NIH CAN THEN 5430 03:09:44,524 --> 03:09:45,391 IMPLEMENT. 5431 03:09:45,391 --> 03:09:48,461 AND THEN NICOLE MENTIONED OUR 5432 03:09:48,461 --> 03:09:52,899 SCIENCE OF SCIENCE SCHOLARS 5433 03:09:52,899 --> 03:09:53,232 PROGRAM. 5434 03:09:53,232 --> 03:09:54,667 RIGHT NOW WE ARE WORKING ON A 5435 03:09:54,667 --> 03:09:59,372 PILOT OF THAT WHERE THIS IS DONE 5436 03:09:59,372 --> 03:10:00,406 IN COLLABORATION WITH OUR OFFICE 5437 03:10:00,406 --> 03:10:01,941 OF EXTRAMURAL RESEARCH, WHERE WE 5438 03:10:01,941 --> 03:10:03,810 PLAN TO BRING IN SCIENCE OF 5439 03:10:03,810 --> 03:10:07,680 SCIENCE SCHOLARS. 5440 03:10:07,680 --> 03:10:08,948 THERE'S NO MONEY INVOLVED, THEY 5441 03:10:08,948 --> 03:10:10,283 WILL BE SPECIAL VOLUNTEERS BUT 5442 03:10:10,283 --> 03:10:11,985 THEY WILL BE WORKING VERY 5443 03:10:11,985 --> 03:10:14,153 CLOSELY, NOT ONLY WILL THEY HAVE 5444 03:10:14,153 --> 03:10:15,455 ACCESS BEHIND THE FIREWALL TO 5445 03:10:15,455 --> 03:10:17,657 ALL OF NIH'S PROPRIETARY DATA, 5446 03:10:17,657 --> 03:10:19,692 BUT THEY WILL BE WORKING VERY 5447 03:10:19,692 --> 03:10:21,327 CLOSELY WITH THOSE PEOPLE WHO 5448 03:10:21,327 --> 03:10:25,598 UNDERSTAND THIS DATA THE BEST. 5449 03:10:25,598 --> 03:10:27,300 AS I MENTIONED, DATE TA CAN BE 5450 03:10:27,300 --> 03:10:28,401 RATHER BYZANTINE AT TIMES 5451 03:10:28,401 --> 03:10:29,602 GETTING THROUGH THAT, BUT BY 5452 03:10:29,602 --> 03:10:31,804 WORKING TOGETHER, IN 5453 03:10:31,804 --> 03:10:32,739 PARTNERSHIP, WE'RE REALLY HOPING 5454 03:10:32,739 --> 03:10:34,741 THAT THIS IS A UNIQUE 5455 03:10:34,741 --> 03:10:37,110 OPPORTUNITY FOR US TO LEARN FROM 5456 03:10:37,110 --> 03:10:38,544 THE FIELD SOME OF THE 5457 03:10:38,544 --> 03:10:40,246 METHODOLOGY THAT THEY WOULD 5458 03:10:40,246 --> 03:10:44,851 APPLY TOWARD EXAMINING THAT 5459 03:10:44,851 --> 03:10:45,184 DATA. 5460 03:10:45,184 --> 03:10:46,152 FOR THOSE WORKING IN THE FIELD 5461 03:10:46,152 --> 03:10:47,687 TO ACTUALLY GET THEIR HANDS ON 5462 03:10:47,687 --> 03:10:49,522 MUCH OF THE DATA THAT THEY ARE 5463 03:10:49,522 --> 03:10:52,558 HOPING TO GET ON. 5464 03:10:52,558 --> 03:10:54,761 AND THERE ARE MANY OTHER 5465 03:10:54,761 --> 03:10:56,062 EXAMPLES THAT WE CAN TALK ABOUT, 5466 03:10:56,062 --> 03:10:57,664 HOW WE'RE TRYING TO ENGAGE WITH 5467 03:10:57,664 --> 03:10:58,898 THE SCIENCE OF SCIENCE 5468 03:10:58,898 --> 03:11:05,438 RESEARCHERS. 5469 03:11:05,438 --> 03:11:06,606 I'M TALKING REALLY FAST BECAUSE 5470 03:11:06,606 --> 03:11:08,141 I AM TRYING TO GET US CAUGHT UP 5471 03:11:08,141 --> 03:11:09,642 A LITTLE BIT ON TIME AS MUCH AS 5472 03:11:09,642 --> 03:11:09,976 POSSIBLE. 5473 03:11:09,976 --> 03:11:11,811 I WANTED TO END WITH WHAT I 5474 03:11:11,811 --> 03:11:14,180 THINK IS A REALLY FASCINATING 5475 03:11:14,180 --> 03:11:14,447 EXAMPLE. 5476 03:11:14,447 --> 03:11:16,149 WE HAVE BEEN TALKING THROUGHOUT 5477 03:11:16,149 --> 03:11:19,652 THE DAY ABOUT METRICS, AND OUR 5478 03:11:19,652 --> 03:11:21,421 FOLKS AT THE NATIONAL EYE 5479 03:11:21,421 --> 03:11:22,488 INSTITUTE IN COLLABORATION WITH 5480 03:11:22,488 --> 03:11:24,590 SEVERAL OTHER INSTITUTES, 5481 03:11:24,590 --> 03:11:25,858 CENTERS AND OFFICES HAVE 5482 03:11:25,858 --> 03:11:27,694 LAUNCHED A CHALLENGE TO TRY AND 5483 03:11:27,694 --> 03:11:31,330 CREATE AN INDEX THAT COULD 5484 03:11:31,330 --> 03:11:36,102 REALLY MEASURE TO SOME DEGREE 5485 03:11:36,102 --> 03:11:38,504 EXEMPLARY DATA SHARING EXAMPLES. 5486 03:11:38,504 --> 03:11:40,440 OR HOW EFFECTIVE IS A RESEARCHER 5487 03:11:40,440 --> 03:11:41,407 IN SHARING THEIR DATA? 5488 03:11:41,407 --> 03:11:43,276 IS THERE A WAY THAT WE CAN BEGIN 5489 03:11:43,276 --> 03:11:46,279 TO CAPTURE THE EFFECTIVENESS OF 5490 03:11:46,279 --> 03:11:47,280 DATA SHARING. 5491 03:11:47,280 --> 03:11:49,482 SO AS I SAID, JUST WANTED TO END 5492 03:11:49,482 --> 03:11:51,718 WITH WHAT I THOUGHT WAS AN 5493 03:11:51,718 --> 03:11:52,285 INTERESTING EXAMPLE. 5494 03:11:52,285 --> 03:11:59,592 THEN IF WE GO TO THE NEXT SLIDE, 5495 03:11:59,592 --> 03:12:02,628 SO WHAT IS NEXT, A SYSTEMATIC 5496 03:12:02,628 --> 03:12:06,032 AND COMPREHENSIVE WAY BY WHICH 5497 03:12:06,032 --> 03:12:07,433 NIH CAN CONTINUALLY STRENGTHEN 5498 03:12:07,433 --> 03:12:09,302 ITS ABILITY TO STUDY ITSELF AND 5499 03:12:09,302 --> 03:12:13,773 HOW DO WE ENGAGE WITH THE 5500 03:12:13,773 --> 03:12:14,640 EXTERNAL SCIENCE OF SCIENCE 5501 03:12:14,640 --> 03:12:17,610 COMMUNITY TO HELP US DO JUST 5502 03:12:17,610 --> 03:12:19,345 THAT. 5503 03:12:19,345 --> 03:12:20,413 WE BELIEVE THESE QUESTIONS AND 5504 03:12:20,413 --> 03:12:21,714 MORE COULD BE ANSWERED BY A 5505 03:12:21,714 --> 03:12:22,615 COUNCIL OF COUNCIL WORKING 5506 03:12:22,615 --> 03:12:22,915 GROUP. 5507 03:12:22,915 --> 03:12:24,450 I WANT TO POINT OUT THAT WE'RE 5508 03:12:24,450 --> 03:12:27,787 NOT LOOKING FOR THE WORKING 5509 03:12:27,787 --> 03:12:29,122 GROUP TO COME UP WITH ALL THE 5510 03:12:29,122 --> 03:12:31,524 NEW METRICS AND INDEXES AND ET 5511 03:12:31,524 --> 03:12:33,593 CETERA THAT WE NEED, BUT RATHER 5512 03:12:33,593 --> 03:12:35,762 TO HELP US TO REALLY THINK 5513 03:12:35,762 --> 03:12:38,498 THROUGH BEST WAYS OF ENGAGING 5514 03:12:38,498 --> 03:12:40,900 WITH THE FIELD, BUT ALSO TO 5515 03:12:40,900 --> 03:12:42,969 THINK THROUGH BEST WAYS FOR US 5516 03:12:42,969 --> 03:12:43,836 TO APPROACH IT. 5517 03:12:43,836 --> 03:12:46,105 HOW CAN WE BE MORE SYSTEMATIC 5518 03:12:46,105 --> 03:12:47,540 AND COMPREHENSIVE IN OUR 5519 03:12:47,540 --> 03:12:48,407 APPROACH TOWARDS STUDYING 5520 03:12:48,407 --> 03:12:53,780 OURSELVES. 5521 03:12:53,780 --> 03:12:55,081 WITH THAT, I'M GOING TO OPEN IT 5522 03:12:55,081 --> 03:12:56,682 UP FOR QUESTIONS, COMMENTS, AND 5523 03:12:56,682 --> 03:12:57,884 I APOLOGIZE IF I WENT REALLY 5524 03:12:57,884 --> 03:12:59,552 FAST, BUT AS I SAID, I THINK WE 5525 03:12:59,552 --> 03:13:01,487 TALKED AN AWFUL LOT EARLIER 5526 03:13:01,487 --> 03:13:06,526 TODAY ABOUT SOME OF THESE IDEAS. 5527 03:13:06,526 --> 03:13:07,593 >> THANKS, MARINA. 5528 03:13:07,593 --> 03:13:09,095 I REALLY APPRECIATE YOUR 5529 03:13:09,095 --> 03:13:10,196 DEDICATION TO GETTING US BACK ON 5530 03:13:10,196 --> 03:13:11,631 TIME AS WELL. 5531 03:13:11,631 --> 03:13:14,300 SO IF COUNCILMEMBERS HAVE ANY 5532 03:13:14,300 --> 03:13:15,568 QUESTIONS OR COMMENTS, PLEASE 5533 03:13:15,568 --> 03:13:18,204 RAISE YOUR HAND, AND I WILL CALL 5534 03:13:18,204 --> 03:13:19,739 ON YOU AND ASK YOU TO UNMUTE 5535 03:13:19,739 --> 03:13:20,173 YOURSELF. 5536 03:13:20,173 --> 03:13:25,778 KEVIN, PLEASE GO AHEAD. 5537 03:13:25,778 --> 03:13:27,180 >> HI, THANKS A LOT. 5538 03:13:27,180 --> 03:13:29,048 MARINA, NICE TO MEET YOU ALSO. 5539 03:13:29,048 --> 03:13:31,317 I'M KEVIN JOHNSON FROM PENN. 5540 03:13:31,317 --> 03:13:32,618 I'M CURIOUS, THERE WAS A TIME 5541 03:13:32,618 --> 03:13:35,354 WHEN COUNCIL AND THE NIH WERE 5542 03:13:35,354 --> 03:13:40,693 THINKING ABOUT SCIENCE 5543 03:13:40,693 --> 03:13:41,360 COMMUNICATION AS A MORE 5544 03:13:41,360 --> 03:13:43,062 ORGANIZED ACTIVITY, ESPECIALLY 5545 03:13:43,062 --> 03:13:45,064 THE TEACHING OF SCIENCE 5546 03:13:45,064 --> 03:13:45,398 COMMUNICATION. 5547 03:13:45,398 --> 03:13:49,001 DO YOU SEE ANY SYNERGIES BETWEEN 5548 03:13:49,001 --> 03:13:50,303 THAT IDEA, RECOGNIZING YOU MAY 5549 03:13:50,303 --> 03:13:53,906 NOT HAVE EVER SEEN THAT CONCEPT, 5550 03:13:53,906 --> 03:13:55,308 AND WHAT WE'RE TRYING TO DO WITH 5551 03:13:55,308 --> 03:13:56,742 THE SCIENCE OF SCIENCE? 5552 03:13:56,742 --> 03:13:58,911 >> WELL, THANK YOU FOR THAT 5553 03:13:58,911 --> 03:14:01,247 QUESTION, AND I'LL ADMIT I'VE 5554 03:14:01,247 --> 03:14:03,249 BEEN AROUND NIH FOR QUITE SOME 5555 03:14:03,249 --> 03:14:06,853 TIME AND WE ACTUALLY HAD A GRANT 5556 03:14:06,853 --> 03:14:09,789 PROGRAM ON SCIENCE COMMUNICATION 5557 03:14:09,789 --> 03:14:10,122 AT ONE POINT. 5558 03:14:10,122 --> 03:14:15,428 AND I ACTUALLY -- I THINK THAT 5559 03:14:15,428 --> 03:14:16,629 SCIENCE COMMUNICATION, SO MUCH 5560 03:14:16,629 --> 03:14:18,331 OF WHAT EVEN DR. BHATTACHARYA 5561 03:14:18,331 --> 03:14:22,501 AND YOU ALL WERE SPEAKING ABOUT 5562 03:14:22,501 --> 03:14:23,703 BEFOREHAND, THE PUBLIC, WHEN 5563 03:14:23,703 --> 03:14:25,972 THEY ASK NIH WHAT ARE WE GETTING 5564 03:14:25,972 --> 03:14:28,241 FOR OUR INVESTMENT IN NIH, WE 5565 03:14:28,241 --> 03:14:34,480 NEED TO BE ABLE TO TELL THEM 5566 03:14:34,480 --> 03:14:37,516 SOMETHING OTHER THAN, HEY, WE 5567 03:14:37,516 --> 03:14:38,517 HAD A LOT OF REALLY GOOD 5568 03:14:38,517 --> 03:14:39,819 PUBLICATIONS IN SCIENCE. 5569 03:14:39,819 --> 03:14:41,587 AND HOW CAN WE BY BETTER 5570 03:14:41,587 --> 03:14:42,989 ASSESSING AND EVALUATING 5571 03:14:42,989 --> 03:14:44,056 OURSELVES, HOW DO WE GENERATE 5572 03:14:44,056 --> 03:14:45,391 EVIDENCE THAT WILL ALSO TELL THE 5573 03:14:45,391 --> 03:14:47,760 PUBLIC, THIS IS WHAT YOU'RE 5574 03:14:47,760 --> 03:14:47,994 GETTING? 5575 03:14:47,994 --> 03:14:49,662 AND IT'S A VERY, VERY TRICKY 5576 03:14:49,662 --> 03:14:53,833 STORY TO TELL, BECAUSE NIH 5577 03:14:53,833 --> 03:14:55,468 PRODUCES THE EVIDENCE BASE THAT 5578 03:14:55,468 --> 03:14:56,769 OTHERS THEN USE TO IMPROVE 5579 03:14:56,769 --> 03:15:00,273 HEALTH. 5580 03:15:00,273 --> 03:15:01,440 AND HOW DO WE TELL PEOPLE HOW 5581 03:15:01,440 --> 03:15:03,075 THIS HAPPENS, HOW DO WE TELL 5582 03:15:03,075 --> 03:15:05,711 PEOPLE ABOUT HOW SCIENCE IS 5583 03:15:05,711 --> 03:15:10,716 IMPLEMENTED, HOW DO WE KNOW WHAT 5584 03:15:10,716 --> 03:15:12,218 NIH RESEARCH IS DIRECTLY LED TO 5585 03:15:12,218 --> 03:15:13,219 SOMETHING THAT DIRECTLY BENEFITS 5586 03:15:13,219 --> 03:15:13,986 THE PUBLIC. 5587 03:15:13,986 --> 03:15:15,721 SO I THINK THAT SCIENCE 5588 03:15:15,721 --> 03:15:16,622 COMMUNICATION, HOW TO 5589 03:15:16,622 --> 03:15:18,024 COMMUNICATE WITH THE PUBLIC 5590 03:15:18,024 --> 03:15:20,393 BETTER, IS OF VITAL IMPORTANCE 5591 03:15:20,393 --> 03:15:21,961 TO THIS EFFORT. 5592 03:15:21,961 --> 03:15:24,597 >> THANK YOU. 5593 03:15:24,597 --> 03:15:25,598 >> THANKS. 5594 03:15:25,598 --> 03:15:27,166 JEAN, PLEASE GO AHEAD. 5595 03:15:27,166 --> 03:15:28,134 SORRY, RHONDA. 5596 03:15:28,134 --> 03:15:28,367 SORRY. 5597 03:15:28,367 --> 03:15:32,305 MY FAULT. 5598 03:15:32,305 --> 03:15:33,072 PLEASE GO AHEAD. 5599 03:15:33,072 --> 03:15:34,607 >> NO PROBLEM, NO PROBLEM. 5600 03:15:34,607 --> 03:15:36,042 SO THANK YOU SO MUCH. 5601 03:15:36,042 --> 03:15:38,644 SO I HAVE A COUPLE QUESTIONS ON 5602 03:15:38,644 --> 03:15:42,214 THIS. 5603 03:15:42,214 --> 03:15:43,215 PRIMARILY FROM THE STANDPOINT OF 5604 03:15:43,215 --> 03:15:45,885 VIEW IF I'M WONDERING WHETHER OR 5605 03:15:45,885 --> 03:15:50,456 NOT THERE IS A SECTOR OF SCIENCE 5606 03:15:50,456 --> 03:15:54,493 THAT MAY NOT NECESSARILY BE PART 5607 03:15:54,493 --> 03:15:56,295 OF WHAT ONE WOULD TYPICALLY 5608 03:15:56,295 --> 03:15:57,129 FOCUS ON. 5609 03:15:57,129 --> 03:15:57,763 AND LET ME CLARIFY. 5610 03:15:57,763 --> 03:15:59,231 I KIND OF HINTED THAT IN SEVERAL 5611 03:15:59,231 --> 03:16:04,303 OF MY QUESTIONS TODAY. 5612 03:16:04,303 --> 03:16:05,004 THIS PARTICULARLY IS IMPORTANT 5613 03:16:05,004 --> 03:16:07,873 IN TERMS OF LINKING SCIENCE TO 5614 03:16:07,873 --> 03:16:09,308 APPLICATION IN THE REAL WORLD 5615 03:16:09,308 --> 03:16:14,146 AND THE DELIVERY SYSTEM. 5616 03:16:14,146 --> 03:16:15,481 CERTAINLY WE DON'T WANT TO KEEP 5617 03:16:15,481 --> 03:16:16,949 THE 17 YEARS IT TAKES FROM A 5618 03:16:16,949 --> 03:16:17,817 SCIENTIFIC FACT TO ACTUALLY 5619 03:16:17,817 --> 03:16:19,251 BEING ADOPTED IN PRACTICE, SO WE 5620 03:16:19,251 --> 03:16:23,589 NEED TO ESCALATE AND MOVE THAT 5621 03:16:23,589 --> 03:16:24,023 QUICKER. 5622 03:16:24,023 --> 03:16:25,224 SO ONE OF THE THINGS I WOULD 5623 03:16:25,224 --> 03:16:26,325 WONDER IS WHETHER THAT IN THE 5624 03:16:26,325 --> 03:16:30,930 SCIENCE OF SCIENCE, WOULD THERE 5625 03:16:30,930 --> 03:16:33,632 BE AREAS WHERE YOU WOULD LOOK AT 5626 03:16:33,632 --> 03:16:35,901 WHAT THE OUTSIDE WORLD NEEDS 5627 03:16:35,901 --> 03:16:38,437 FROM THE STANDPOINT OF VIEW OF 5628 03:16:38,437 --> 03:16:40,172 CARE DELIVERY? 5629 03:16:40,172 --> 03:16:42,441 THERE ARE MANY GAPS OUT THERE, 5630 03:16:42,441 --> 03:16:44,710 I'LL SAY MY COLLEAGUES ARE NOT 5631 03:16:44,710 --> 03:16:46,612 VERY GOOD AT COMMUNICATING THOSE 5632 03:16:46,612 --> 03:16:49,348 AND PROBABLY NEED TO DO THAT. 5633 03:16:49,348 --> 03:16:52,852 BUT TO HELP THE RESEARCH AREA TO 5634 03:16:52,852 --> 03:16:53,819 UNDERSTAND WHERE THE PAIN POINTS 5635 03:16:53,819 --> 03:16:55,321 ARE. 5636 03:16:55,321 --> 03:16:57,623 BUT ALSO YOU AS THE RESEARCH 5637 03:16:57,623 --> 03:17:00,259 AREA CONNECT WITH THOSE AREAS 5638 03:17:00,259 --> 03:17:01,894 THAT CREATE GUIDELINES, 5639 03:17:01,894 --> 03:17:04,830 CONSENSUS DOCUMENTS, AND THE NEW 5640 03:17:04,830 --> 03:17:06,565 TERM NOW IS PLAYBOOKS THAT 5641 03:17:06,565 --> 03:17:09,435 ACTUALLY DEMONSTRATE HOWL TO 5642 03:17:09,435 --> 03:17:11,037 OPERATIONALIZE SOME NEW SCIENCE 5643 03:17:11,037 --> 03:17:14,640 AND SOME WAY TO HELP BRING THE 5644 03:17:14,640 --> 03:17:16,175 RELIABILITY OF IMPLEMENTING IT 5645 03:17:16,175 --> 03:17:22,214 WITH EFFECTIVENESS. 5646 03:17:22,214 --> 03:17:23,516 SO MY THING IS, THERE'S ANOTHER 5647 03:17:23,516 --> 03:17:25,017 AREA THAT NEEDS TO BE THOUGHT. 5648 03:17:25,017 --> 03:17:26,652 NUMBER TWO, WE NEED TO GO BEYOND 5649 03:17:26,652 --> 03:17:30,356 WHAT NIH CAN DO, NIH NEEDS TO 5650 03:17:30,356 --> 03:17:34,293 JOIN HANDS WITH THE CONSENSUS 5651 03:17:34,293 --> 03:17:35,294 ORGANIZATIONS, AS WELL AS THE 5652 03:17:35,294 --> 03:17:36,262 FUNDING ORGANIZATION THAT KIND 5653 03:17:36,262 --> 03:17:39,865 OF FUND NON-RESEARCH HFN BASED 5654 03:17:39,865 --> 03:17:41,067 NEW INFRASTRUCTURES AND 5655 03:17:41,067 --> 03:17:42,601 FUNCTIONS WITHIN THE HEALTHCARE 5656 03:17:42,601 --> 03:17:45,438 DELIVERY SYSTEM. 5657 03:17:45,438 --> 03:17:46,939 I HOPE THAT WASN'T TOO 5658 03:17:46,939 --> 03:17:47,206 CONFUSING. 5659 03:17:47,206 --> 03:17:50,076 >> OH, NO, NO, NO, AND I WANT TO 5660 03:17:50,076 --> 03:17:51,944 TELL YOU THAT I AGREE AND HAVE 5661 03:17:51,944 --> 03:17:56,649 RESONATED THROUGHOUT THE DAY 5662 03:17:56,649 --> 03:17:57,416 WITH POINTS YOU CONTINUALLY 5663 03:17:57,416 --> 03:17:58,184 MAKE. 5664 03:17:58,184 --> 03:18:01,687 AGAIN, NIH ONLY CAN ACHIEVE ITS 5665 03:18:01,687 --> 03:18:05,624 MISSION IF OTHERS TAKE THE 5666 03:18:05,624 --> 03:18:07,693 RESEARCH THAT NIH PR PRODUCES AD 5667 03:18:07,693 --> 03:18:09,028 ACTUALLY APPLY IT. 5668 03:18:09,028 --> 03:18:10,529 TO UNDERSTAND THAT HANDOFF, TO 5669 03:18:10,529 --> 03:18:12,064 UNDERSTAND THE CHAIN OF 5670 03:18:12,064 --> 03:18:13,032 EVIDENCE, THE EVIDENCE FLOW THAT 5671 03:18:13,032 --> 03:18:15,201 GOES FROM RESEARCH INTO 5672 03:18:15,201 --> 03:18:15,968 PRACTICE, ULTIMATELY INTO 5673 03:18:15,968 --> 03:18:16,969 IMPROVEMENTS IN HEALTH AND THEN 5674 03:18:16,969 --> 03:18:21,006 THE SPILLOVER EFFECTS, THAT'S 5675 03:18:21,006 --> 03:18:22,608 THE NUMBER ONE QUESTION, I 5676 03:18:22,608 --> 03:18:26,145 THINK, THAT THIS EFFORT HAS TO 5677 03:18:26,145 --> 03:18:27,246 REALLY START TO LOOK AT 5678 03:18:27,246 --> 03:18:29,615 DIFFERENT WAYS OF BUILDING THAT 5679 03:18:29,615 --> 03:18:31,350 CHAIN OF EVIDENCE AND 5680 03:18:31,350 --> 03:18:32,218 UNDERSTANDING AND FINDING THE 5681 03:18:32,218 --> 03:18:34,620 MARKERS OF WHEN IT ACTUALLY DOES 5682 03:18:34,620 --> 03:18:35,955 HAPPEN. 5683 03:18:35,955 --> 03:18:38,457 I WILL SAY ONE THING WE HAVE 5684 03:18:38,457 --> 03:18:41,160 TALKED EXTENSIVELY WITH, EVEN 5685 03:18:41,160 --> 03:18:43,362 WITHIN OUR OWN DEPARTMENT, IN 5686 03:18:43,362 --> 03:18:46,198 ORDER FOR NIH, RESEARCH TO HAVE 5687 03:18:46,198 --> 03:18:47,299 ANY IMPACT, IT NEEDS TO TOUCH 5688 03:18:47,299 --> 03:18:48,701 OTHER PARTS OF OUR OWN 5689 03:18:48,701 --> 03:18:49,034 DEPARTMENT. 5690 03:18:49,034 --> 03:18:51,537 WHETHER IT BE FDA OR CMS, ET 5691 03:18:51,537 --> 03:18:52,338 CETERA. 5692 03:18:52,338 --> 03:18:56,041 HOW DO WE BEGIN TO KNOW, HOW DO 5693 03:18:56,041 --> 03:18:58,878 WE BEGIN TO CAPTURE THAT 5694 03:18:58,878 --> 03:19:00,946 EVIDENCE FLOW OF NIH WITH OTHER 5695 03:19:00,946 --> 03:19:02,148 PARTS OF ITS SISTER 5696 03:19:02,148 --> 03:19:04,116 ORGANIZATIONS WITHIN THE 5697 03:19:04,116 --> 03:19:06,118 DEPARTMENT, NOT EVEN GOING TO 5698 03:19:06,118 --> 03:19:08,387 THE OUTSIDE, TO THE 5699 03:19:08,387 --> 03:19:09,922 PRACTITIONERS, BUT EVEN TO BEGIN 5700 03:19:09,922 --> 03:19:11,357 BY UNDERSTANDING EVIDENCE FLOW 5701 03:19:11,357 --> 03:19:13,893 WITHIN THE DEPARTMENT. 5702 03:19:13,893 --> 03:19:17,196 IF YOU LOOK AT THE SMRB REPORT 5703 03:19:17,196 --> 03:19:19,598 ON THE VALUE OF BIOMEDICAL 5704 03:19:19,598 --> 03:19:22,735 RESEARCH, IT IS ALL ABOUT HOW TO 5705 03:19:22,735 --> 03:19:25,070 MAKE THAT -- HOW WE CAN 5706 03:19:25,070 --> 03:19:25,938 STRENGTHEN OUR ABILITY TO 5707 03:19:25,938 --> 03:19:27,373 CAPTURE THAT CHAIN OF EVIDENCE 5708 03:19:27,373 --> 03:19:30,743 AS IT FLOWS FROM RESEARCH INTO 5709 03:19:30,743 --> 03:19:34,246 ACTUAL CHANGES IN HEALTH. 5710 03:19:34,246 --> 03:19:35,548 I HOPE THAT ADDRESSES -- 5711 03:19:35,548 --> 03:19:38,150 >> YES, IT DOES, AND I HOPE THAT 5712 03:19:38,150 --> 03:19:41,020 PART OF THE SCOPE OF WORK THAT 5713 03:19:41,020 --> 03:19:43,322 THIS UNIT WILL DO WILL BEGIN TO 5714 03:19:43,322 --> 03:19:46,992 LOOK AT HOW TO MAP THAT OUT AND 5715 03:19:46,992 --> 03:19:48,761 CREATE THOSE RELATIONSHIPS THAT 5716 03:19:48,761 --> 03:19:50,629 ALLOWS THAT TO HAPPEN. 5717 03:19:50,629 --> 03:19:53,098 AND CERTAINLY WE'D BE VERY 5718 03:19:53,098 --> 03:19:53,799 INTERESTED IN THAT. 5719 03:19:53,799 --> 03:19:55,134 I'M GOING OFF COUNCIL BUT VERY 5720 03:19:55,134 --> 03:19:57,403 INTERESTED IN THAT BEING 5721 03:19:57,403 --> 03:19:57,803 FURTHERED ALONG. 5722 03:19:57,803 --> 03:20:00,673 >> I HOPE THAT WE CAN CONTINUE 5723 03:20:00,673 --> 03:20:04,710 TO ASK FOR YOUR INPUT ON THESE 5724 03:20:04,710 --> 03:20:06,378 THINGS. 5725 03:20:06,378 --> 03:20:08,013 >> OKAY, GREAT. 5726 03:20:08,013 --> 03:20:10,182 AND JEAN, PLEASE GO AHEAD. 5727 03:20:10,182 --> 03:20:12,484 >> THANKS FOR BRINGING BACK THE 5728 03:20:12,484 --> 03:20:12,851 GINTHER EFFECT. 5729 03:20:12,851 --> 03:20:14,220 I HAVE TO SAY I STILL THINK 5730 03:20:14,220 --> 03:20:15,921 ABOUT IT AND I WAS SO GRATEFUL 5731 03:20:15,921 --> 03:20:16,956 FOR THAT STUDY. 5732 03:20:16,956 --> 03:20:19,692 WE ALL HAD STORIES TO TELL, AND 5733 03:20:19,692 --> 03:20:21,560 FINALLY SHE SORT OF BROUGHT THE 5734 03:20:21,560 --> 03:20:22,661 DATA TOGETHER TO SEE THAT THERE 5735 03:20:22,661 --> 03:20:24,063 WAS DATA TO SUPPORT WHAT WE 5736 03:20:24,063 --> 03:20:25,931 THOUGHT WAS HAPPENING ANYWAY. 5737 03:20:25,931 --> 03:20:27,366 SO I AGREE, I STILL TALK ABOUT 5738 03:20:27,366 --> 03:20:30,002 THAT STUDY AND IT'S OVER A 5739 03:20:30,002 --> 03:20:31,737 DECADE OLD, I THINK, BY NOW. 5740 03:20:31,737 --> 03:20:34,807 BUT WHAT I WANTED TO BRING TO 5741 03:20:34,807 --> 03:20:36,875 THIS IS, AS WE TALK ABOUT 5742 03:20:36,875 --> 03:20:37,876 COMMUNICATION, I THINK THE 5743 03:20:37,876 --> 03:20:38,944 GENERAL PUBLIC UNDERSTANDS 5744 03:20:38,944 --> 03:20:40,045 STORIES, THEY UNDERSTAND 5745 03:20:40,045 --> 03:20:40,479 NARRATIVES. 5746 03:20:40,479 --> 03:20:44,416 THEY MAY NOT UNDERSTAND A 5747 03:20:44,416 --> 03:20:45,284 PARTICULAR CHANNEL AND HOW I 5748 03:20:45,284 --> 03:20:46,585 COULD BLOCK THAT CHANNEL OR 5749 03:20:46,585 --> 03:20:49,421 WHATEVER IT IS I COULD DO, BUT 5750 03:20:49,421 --> 03:20:51,090 IT UNDERSTANDS IF A DRUG WORKS 5751 03:20:51,090 --> 03:20:53,559 FOR A CERTAIN PERSON IN A 5752 03:20:53,559 --> 03:20:53,926 CLINICAL TRIAL. 5753 03:20:53,926 --> 03:20:55,127 WE HAVE TO PUT MORE OF THOSE OUT 5754 03:20:55,127 --> 03:20:56,462 THERE, THOSE STORIES FROM PEOPLE 5755 03:20:56,462 --> 03:20:58,097 IN THEIR COMMUNITIES, IN THEIR 5756 03:20:58,097 --> 03:20:59,698 NEIGHBORHOOD WHO JUST SAID LOOK, 5757 03:20:59,698 --> 03:21:01,900 IT WAS ON THIS CLINICAL TRIAL, 5758 03:21:01,900 --> 03:21:03,235 THIS DRUG HELPED MY SON, IT 5759 03:21:03,235 --> 03:21:03,669 HELPED ME. 5760 03:21:03,669 --> 03:21:05,537 I THINK WE WANT TO BRING 5761 03:21:05,537 --> 03:21:06,405 PERSONALIZED STORIES TO THIS. 5762 03:21:06,405 --> 03:21:07,873 I THINK WHEN SCIENTIST DOES IT, 5763 03:21:07,873 --> 03:21:09,975 WE'RE TALKING ABOUT THE 5764 03:21:09,975 --> 03:21:12,511 INCLUSIVE DATA OF EVERYTHING WE 5765 03:21:12,511 --> 03:21:13,612 STUDIED, THE GRAPHS, THE 5766 03:21:13,612 --> 03:21:14,046 STATISTICS. 5767 03:21:14,046 --> 03:21:16,015 WE MAY LOSE THEM, I DON'T SAY WE 5768 03:21:16,015 --> 03:21:17,249 ALWAYS DO BUT WE CAN, BUT I 5769 03:21:17,249 --> 03:21:19,084 THINK A STORY DOESN'T LOSE 5770 03:21:19,084 --> 03:21:19,752 SOMEONE. 5771 03:21:19,752 --> 03:21:21,387 AND I THINK WE HAVE TO BE BETTER 5772 03:21:21,387 --> 03:21:22,588 AT TELLING STORIES. 5773 03:21:22,588 --> 03:21:24,123 AND I AGREE, SOME SCIENTISTS 5774 03:21:24,123 --> 03:21:28,594 WEARENOT GOOD AT IT. 5775 03:21:28,594 --> 03:21:30,562 THEY'RE INTROVERTS, THEY WANT TO 5776 03:21:30,562 --> 03:21:32,998 BE IN THEIR LABS, I DON'T THINK 5777 03:21:32,998 --> 03:21:34,733 THEY'RE THE ONES WE NECESSARILY 5778 03:21:34,733 --> 03:21:35,868 NEED TO EXPLAIN THE SCIENCE. 5779 03:21:35,868 --> 03:21:37,870 WE HAVE TO HAVE PEOPLE WHO 5780 03:21:37,870 --> 03:21:38,704 COMMUNICATE SCIENCE TO OTHERS IN 5781 03:21:38,704 --> 03:21:39,772 SOCIETY IN A WAY THAT MAKES 5782 03:21:39,772 --> 03:21:40,205 SENSE. 5783 03:21:40,205 --> 03:21:41,340 IT DOESN'T HAVE TO BE THE 5784 03:21:41,340 --> 03:21:42,041 RESEARCHER THEMSELVES. 5785 03:21:42,041 --> 03:21:44,643 IT CAN BE IF THAT'S THEIR 5786 03:21:44,643 --> 03:21:45,744 PROCLIVITY AND THEY'RE GOOD AT 5787 03:21:45,744 --> 03:21:46,045 IT. 5788 03:21:46,045 --> 03:21:47,279 IT DOESN'T HAVE TO BE. 5789 03:21:47,279 --> 03:21:48,847 I THINK SOMETIMES WE MISS THE 5790 03:21:48,847 --> 03:21:50,549 POINT BY HAVING A SCIENTIST TRY 5791 03:21:50,549 --> 03:21:51,850 TO EXPLAIN IT IN LANGUAGE THAT 5792 03:21:51,850 --> 03:21:54,153 THEY'RE NOT USED TO USING, AND 5793 03:21:54,153 --> 03:21:55,220 THEY'RE NOT COMFORTABLE WITH. 5794 03:21:55,220 --> 03:21:58,824 I THINK WE NEED TO FIND WAYS TO 5795 03:21:58,824 --> 03:22:00,959 ACTUALLY HAVE INTERPRETERS OF 5796 03:22:00,959 --> 03:22:03,862 SCIENCE WHO COULD TALK TO 5797 03:22:03,862 --> 03:22:05,964 SOCIETY AND TALK TO PEOPLE AT 5798 03:22:05,964 --> 03:22:06,932 WHATEVER LEVEL THEY'RE AT TO 5799 03:22:06,932 --> 03:22:08,233 MAKE SURE STORIES GET THROUGH TO 5800 03:22:08,233 --> 03:22:08,567 THEM. 5801 03:22:08,567 --> 03:22:09,902 BUT I THINK IF SOMEBODY SAID I 5802 03:22:09,902 --> 03:22:11,203 WAS CURED CH THIS ILLNESS OR 5803 03:22:11,203 --> 03:22:12,638 THIS THING HAPPENED TO ME OR MY 5804 03:22:12,638 --> 03:22:13,305 SON IS BETTER BECAUSE OF THIS, 5805 03:22:13,305 --> 03:22:14,840 HE WAS ON THE AUTISM SPECTRUM, 5806 03:22:14,840 --> 03:22:18,310 THIS IS WHAT HAPPENED, WE HAVE 5807 03:22:18,310 --> 03:22:19,311 TO COMMUNICATE STORIES IF WE 5808 03:22:19,311 --> 03:22:20,612 WANT TO REACH EVERYONE. 5809 03:22:20,612 --> 03:22:22,815 EVERYONE GETS A STORY. 5810 03:22:22,815 --> 03:22:24,116 >> AGREED. 5811 03:22:24,116 --> 03:22:26,185 AND WE NEED TO BE ABLE TO 5812 03:22:26,185 --> 03:22:29,588 CAPTURE THOSE STORIES. 5813 03:22:29,588 --> 03:22:34,927 AND STORILY HAVE ON HAND STORIES 5814 03:22:34,927 --> 03:22:36,362 TO SUPPLEMENT WHATEVER KINDS OF 5815 03:22:36,362 --> 03:22:37,796 APPROACHES THAT WE HAVE TOWARDS 5816 03:22:37,796 --> 03:22:45,204 UNDERSTANDING OUR IMPACT. 5817 03:22:45,204 --> 03:22:49,575 RELATEDLY, WE WON'T BE ABLE TO 5818 03:22:49,575 --> 03:22:50,909 STUDY EVERYTHING THAT NIH DOES, 5819 03:22:50,909 --> 03:22:55,280 SO WE ALSO, RELATED TO BEING 5820 03:22:55,280 --> 03:22:56,815 ABLE TO TELL THE STORY IS TO BE 5821 03:22:56,815 --> 03:22:58,350 ABLE TO STUDY ACTUAL CASE 5822 03:22:58,350 --> 03:22:58,884 STUDIES. 5823 03:22:58,884 --> 03:23:01,520 CAN WE FUND GOOD EXAMPLES WHERE 5824 03:23:01,520 --> 03:23:02,821 SCIENCE HAS WORKED THE WAY WE 5825 03:23:02,821 --> 03:23:04,823 WANT TO WORK, AND HAS RESULTED 5826 03:23:04,823 --> 03:23:07,526 IN WAYS THAT WE HAVE CAPTURED IN 5827 03:23:07,526 --> 03:23:08,961 CHANGING HEALTH. 5828 03:23:08,961 --> 03:23:11,230 IN MEETING NIH'S MISSION. 5829 03:23:11,230 --> 03:23:12,965 CAN WE FIND THOSE STORIES AND 5830 03:23:12,965 --> 03:23:13,966 PACKAGE THEM IN A WAY THAT THE 5831 03:23:13,966 --> 03:23:18,270 PUBLIC CAN UNDERSTAND. 5832 03:23:18,270 --> 03:23:19,671 >> WE HAVE MANY OF THOSE 5833 03:23:19,671 --> 03:23:20,205 STORIES, SO YES. 5834 03:23:20,205 --> 03:23:22,274 >> YES, WE DO, AND OUR OFFICE, 5835 03:23:22,274 --> 03:23:23,375 THAT IS ONE OF THE THINGS THAT 5836 03:23:23,375 --> 03:23:28,981 OUR OFFICE WORKS ON AS WELL. 5837 03:23:28,981 --> 03:23:29,515 >> GREAT. 5838 03:23:29,515 --> 03:23:33,519 SO YOU SAN, PLE 5839 03:23:33,519 --> 03:23:35,254 >> SUSAN, GO AHEAD. 5840 03:23:35,254 --> 03:23:36,889 >> MARINA, THANK YOU FOR YOUR 5841 03:23:36,889 --> 03:23:37,222 COMMENTS. 5842 03:23:37,222 --> 03:23:38,490 ONE THING WE HAVEN'T MENTIONED 5843 03:23:38,490 --> 03:23:39,958 IS THAT BASIC RESEARCH SOMETIMES 5844 03:23:39,958 --> 03:23:43,996 IS BASIC RESEARCH AND IT'S NOT 5845 03:23:43,996 --> 03:23:46,498 REALLY -- DISCOVER FOR 15 OR 20 5846 03:23:46,498 --> 03:23:46,965 YEARS. 5847 03:23:46,965 --> 03:23:49,401 NIH KEEPS CHANGING, SOME 5848 03:23:49,401 --> 03:23:51,136 THOUGHTS ARE, YOU KNOW, FUNDED 5849 03:23:51,136 --> 03:23:52,671 TODAY BUT NOT FUNDED TOMORROW. 5850 03:23:52,671 --> 03:23:56,875 HOW CAN WE BE SURE THAT WE 5851 03:23:56,875 --> 03:23:57,976 REALLY -- FIRST WE SUPPORT BASIC 5852 03:23:57,976 --> 03:23:59,845 SCIENCE FOR THE SAKE OF 5853 03:23:59,845 --> 03:24:01,713 INVESTIGATING SOMETHING THAT IS 5854 03:24:01,713 --> 03:24:03,248 IMPORTANT, THAT MAYBE LATER ON 5855 03:24:03,248 --> 03:24:06,385 IT GOING TO BE USED FOR HUMAN 5856 03:24:06,385 --> 03:24:07,953 HEALTH AND TO IMPROVE THE HEALTH 5857 03:24:07,953 --> 03:24:09,721 OF THE AMERICANS, BUT HOW CAN WE 5858 03:24:09,721 --> 03:24:13,625 MAKE SURE THAT WE CAPTURE THE 5859 03:24:13,625 --> 03:24:15,394 STORIES AND WE LINK THEM ALL THE 5860 03:24:15,394 --> 03:24:17,329 WAY THROUGH THE YEARS TO CURRENT 5861 03:24:17,329 --> 03:24:17,896 DISCOVERIES? 5862 03:24:17,896 --> 03:24:21,166 >> YES, AND BELIEVE ME, WE HAVE 5863 03:24:21,166 --> 03:24:23,268 BEEN TALKING ABOUT THAT, BECAUSE 5864 03:24:23,268 --> 03:24:27,072 IN THE INSTANCE OF BASIC SCIENCE 5865 03:24:27,072 --> 03:24:28,841 TOO, HOW DO WE BEGIN TO SHOW HOW 5866 03:24:28,841 --> 03:24:31,143 A DISCOVERY HERE HAD SUCH 5867 03:24:31,143 --> 03:24:32,244 INFLUENCE IN SO MANY DIFFERENT 5868 03:24:32,244 --> 03:24:32,444 WAYS? 5869 03:24:32,444 --> 03:24:36,048 HOW DO WE SHOW THE DIFFUSION OF 5870 03:24:36,048 --> 03:24:39,451 THAT FINDING AND, YOU KNOW, FOR 5871 03:24:39,451 --> 03:24:40,986 EXAMPLE, CRISPR HAS BEEN USED 5872 03:24:40,986 --> 03:24:43,188 MANY TIMES TO SHOW JUST THAT. 5873 03:24:43,188 --> 03:24:45,324 THIS IS WHAT CRISPR HAS MEANT IN 5874 03:24:45,324 --> 03:24:47,259 SO MANY DIFFERENT AREAS. 5875 03:24:47,259 --> 03:24:49,428 HOW DO WE BEGIN TO BUILD MORE 5876 03:24:49,428 --> 03:24:51,930 EXAMPLES SUCH AS THAT, AND ONCE 5877 03:24:51,930 --> 03:24:53,165 WE HAVE THOSE EXAMPLE, WHAT DO 5878 03:24:53,165 --> 03:24:54,166 WE LEARN FROM THEM? 5879 03:24:54,166 --> 03:24:56,869 HOW DID THESE BASIC SCIENCE 5880 03:24:56,869 --> 03:25:00,939 DISCOVERIES, WH WHAT WAS IT ABOT 5881 03:25:00,939 --> 03:25:02,374 THEM THAT MADE THEM DIFFUSE A 5882 03:25:02,374 --> 03:25:03,976 CERTAIN WAY OR WHAT ABOUT THEM 5883 03:25:03,976 --> 03:25:07,913 CAN WE REPEAT IN FURTHER SUPPORT 5884 03:25:07,913 --> 03:25:11,683 OF BASIC SCIENCE. 5885 03:25:11,683 --> 03:25:13,085 >> THANK YOU VERY MUCH. 5886 03:25:13,085 --> 03:25:14,920 SOMETIMES THOSE FINDINGS ARE 5887 03:25:14,920 --> 03:25:15,821 SERENDIPITOUS, THEY'RE 5888 03:25:15,821 --> 03:25:17,222 INTERESTING, THEY'RE SO BASIC 5889 03:25:17,222 --> 03:25:18,857 THAT MAYBE WE DON'T EVEN KNOW 5890 03:25:18,857 --> 03:25:22,127 HOW THEY'RE GOING TO BE APPLIED. 5891 03:25:22,127 --> 03:25:22,928 THEY'RE JUST SUPER FUN AND 5892 03:25:22,928 --> 03:25:26,632 INTERESTING AND THEY NEED TO BE 5893 03:25:26,632 --> 03:25:26,899 PUBLISHED. 5894 03:25:26,899 --> 03:25:28,567 >> IS THERE A WAY LIKE YOU CAN 5895 03:25:28,567 --> 03:25:33,872 TAG A BIRD AND WATCH THE BIRD'S 5896 03:25:33,872 --> 03:25:35,073 MIGRATION, CAN YOU TAG AN IDEA 5897 03:25:35,073 --> 03:25:37,776 AND WATCH IT MIGRATE THROUGHOUT 5898 03:25:37,776 --> 03:25:38,010 SCIENCE? 5899 03:25:38,010 --> 03:25:39,011 WE HAVE TALKED ABOUT THAT QUITE 5900 03:25:39,011 --> 03:25:39,811 A BIT. 5901 03:25:39,811 --> 03:25:45,050 HOW DO YOU KNOW IN 20 YEARS WHEN 5902 03:25:45,050 --> 03:25:47,986 THIS ONE FINDING HAS RESULTED IN 5903 03:25:47,986 --> 03:25:50,856 MANY DIFFERENT IMPACTS? 5904 03:25:50,856 --> 03:25:52,157 >> THANK YOU. 5905 03:25:52,157 --> 03:25:55,327 I WOULD ALSO ADD FROM MY 5906 03:25:55,327 --> 03:25:57,529 PERSPECTIVE WHILE THIS IS 5907 03:25:57,529 --> 03:25:58,597 INCREDIBLY IMPORTANT TO 5908 03:25:58,597 --> 03:26:00,566 HIGHLIGHT SUCCESS STORIES. 5909 03:26:00,566 --> 03:26:01,800 PART OF THE SCIENCE OF SCIENCE 5910 03:26:01,800 --> 03:26:03,735 IS ALSO TAKING A CRITICAL AND 5911 03:26:03,735 --> 03:26:05,704 TRANSPARENT LOOK AT WHERE 5912 03:26:05,704 --> 03:26:07,806 RESEARCH HAS NOT SUCCEEDED. 5913 03:26:07,806 --> 03:26:09,541 AND UNDERSTANDING, YOU KNOW, 5914 03:26:09,541 --> 03:26:12,945 WHERE THERE ARE ALSO NEGATIVE 5915 03:26:12,945 --> 03:26:15,581 FINDINGS OR A LACK OF 5916 03:26:15,581 --> 03:26:17,316 TRANSLATION AND REALLY PUTTING A 5917 03:26:17,316 --> 03:26:18,717 TRANSPARENT LENS ON THAT SO THAT 5918 03:26:18,717 --> 03:26:24,089 WE CAN LEARN FROM OUR -- I DON'T 5919 03:26:24,089 --> 03:26:26,858 WANT TO SAY FAILURES BUT OUR 5920 03:26:26,858 --> 03:26:28,093 NEGATIVE JUST AS MUCH AS OUR 5921 03:26:28,093 --> 03:26:28,594 POSITIVE INSIGHTS. 5922 03:26:28,594 --> 03:26:29,695 SO THAT'S JUST ONE THING I WOULD 5923 03:26:29,695 --> 03:26:31,997 ADD TO THIS DISCUSSION. 5924 03:26:31,997 --> 03:26:32,864 KENT, AND THEN I THINK WE'LL 5925 03:26:32,864 --> 03:26:33,231 MOVE ON. 5926 03:26:33,231 --> 03:26:34,666 THANKS. 5927 03:26:34,666 --> 03:26:36,368 >> I JUST WANTED TO SAY, I THINK 5928 03:26:36,368 --> 03:26:37,970 IT'S A GREAT IDEA, I FULLY 5929 03:26:37,970 --> 03:26:38,837 SUPPORT IF WE'RE GOING TO VOTE 5930 03:26:38,837 --> 03:26:40,272 ON THIS TO PROCEED WITH A 5931 03:26:40,272 --> 03:26:40,806 WORKING GROUP. 5932 03:26:40,806 --> 03:26:49,147 THANKS. 5933 03:26:49,147 --> 03:26:50,148 >> OKAY. 5934 03:26:50,148 --> 03:26:50,482 WONDERFUL. 5935 03:26:50,482 --> 03:26:52,651 THANK YOU ALL FOR YOUR COMMENTS 5936 03:26:52,651 --> 03:26:55,153 AND YOUR IDEAS. 5937 03:26:55,153 --> 03:26:58,590 I DON'T THINK THAT THIS IS THE 5938 03:26:58,590 --> 03:26:59,825 DECISIONAL AGENDA ITEM SO THERE 5939 03:26:59,825 --> 03:27:01,660 WILL NOT BE A VOTE ON IT, BUT I 5940 03:27:01,660 --> 03:27:03,862 THINK IT'S CLEAR THAT THERE IS 5941 03:27:03,862 --> 03:27:05,197 SUPPORT FOR HAVING A WORKING 5942 03:27:05,197 --> 03:27:06,565 GROUP ON SCIENCE OF SCIENCE, SO 5943 03:27:06,565 --> 03:27:07,532 THANK YOU ALL FOR YOUR FEEDBACK 5944 03:27:07,532 --> 03:27:09,001 ON THAT. 5945 03:27:09,001 --> 03:27:12,137 SO OUR NEXT CONCEPT CLEARANCE IS 5946 03:27:12,137 --> 03:27:13,939 FROM THE OFFICE OF STRATEGIC 5947 03:27:13,939 --> 03:27:14,506 COORDINATION. 5948 03:27:14,506 --> 03:27:16,808 SO THIS NEW CONCEPT IS ENTITLED 5949 03:27:16,808 --> 03:27:19,077 THE CELLULAR SENESCENCE NETWORK 5950 03:27:19,077 --> 03:27:21,113 OR THE SENNET PROGRAM. 5951 03:27:21,113 --> 03:27:24,616 IT WILL BE PRESENTED BY THE NIA 5952 03:27:24,616 --> 03:27:26,151 DIRECTOR DR. RICHARD HODES. 5953 03:27:26,151 --> 03:27:26,918 THE PRESENTATION WILL BE 5954 03:27:26,918 --> 03:27:28,687 FOLLOWED BY COMMENTS FROM TWO 5955 03:27:28,687 --> 03:27:30,856 ASSIGNED COUNCILMEMBER 5956 03:27:30,856 --> 03:27:32,391 DISCUSSANTS, DRS. KENT LLOYD AND 5957 03:27:32,391 --> 03:27:34,359 DR. JENNIFER MANLY. 5958 03:27:34,359 --> 03:27:35,460 RICHARD, I'LL TURN IT OVER TO 5959 03:27:35,460 --> 03:27:35,894 YOU. 5960 03:27:35,894 --> 03:27:36,094 ?REUSH 5961 03:27:36,094 --> 03:27:36,428 >> THANK YOU. 5962 03:27:36,428 --> 03:27:37,295 THANK YOU VERY MUCH FOR THE 5963 03:27:37,295 --> 03:27:38,730 OPPORTUNITY TO PRESENT. 5964 03:27:38,730 --> 03:27:42,467 JUST TO CLARIFY, THIS IS NOT A 5965 03:27:42,467 --> 03:27:43,969 NEW INITIATIVE. 5966 03:27:43,969 --> 03:27:45,637 THIS IS A REPORT BACK TO YOU ON 5967 03:27:45,637 --> 03:27:47,706 THE RESULTS OF THE FIRST PHASE, 5968 03:27:47,706 --> 03:27:50,609 WHICH WAS APPROVED AND MONITORED 5969 03:27:50,609 --> 03:27:54,079 BY THE COUNCIL, AND NOW WE HAVE 5970 03:27:54,079 --> 03:27:54,780 THE OPPORTUNITY TO PRESENT TO 5971 03:27:54,780 --> 03:27:56,615 YOU A PROPOSAL FOR MOVING ON 5972 03:27:56,615 --> 03:27:58,583 TOITY SECOND STAGE. 5973 03:27:58,583 --> 03:27:59,151 TO 5974 03:27:59,151 --> 03:27:59,551 ITS SECOND STAGE. 5975 03:27:59,551 --> 03:28:00,786 THIS IS AN OUTLINE OF THE 5976 03:28:00,786 --> 03:28:01,119 CONCEPT. 5977 03:28:01,119 --> 03:28:04,623 I'LL GO THROUGH IN SOME FURTHER 5978 03:28:04,623 --> 03:28:07,959 DETAIL THE PRODUCTIVITY OF THE 5979 03:28:07,959 --> 03:28:09,127 INITIAL INITIATIVE, THE PROCESS 5980 03:28:09,127 --> 03:28:10,062 THAT'S GONE INTO THE FORMULATION 5981 03:28:10,062 --> 03:28:12,631 OF THE PROPOSAL FOR THE SECOND 5982 03:28:12,631 --> 03:28:14,232 STAGE, AND THEN THE INFORMATION 5983 03:28:14,232 --> 03:28:17,869 WHICH MAY FEED INTO THE 5984 03:28:17,869 --> 03:28:19,304 INFORMATIONAL VOTE FOR APPROVAL 5985 03:28:19,304 --> 03:28:22,441 AGAIN AT THE EXTENSION TO PHASE 5986 03:28:22,441 --> 03:28:27,212 TWO OF THE SENNET PROGRAM. 5987 03:28:27,212 --> 03:28:28,747 SO THANKS FOR ALL WHO HAVE BEEN 5988 03:28:28,747 --> 03:28:30,282 WORKING OVER THE PAST NEARLY 5989 03:28:30,282 --> 03:28:31,583 FIVE YEARS ON THIS. 5990 03:28:31,583 --> 03:28:33,652 DANA SINGER, PARTNER FROM NCI 5991 03:28:33,652 --> 03:28:41,760 WITH NIA, HAVE BEEN -- ALL THOSE 5992 03:28:41,760 --> 03:28:43,195 YOU CAN SEE HERE REPRESENTING 5993 03:28:43,195 --> 03:28:45,597 INPUT FROM MULTIPLE OF THE 5994 03:28:45,597 --> 03:28:48,767 INSTITUTES AT NIH BECAUSE 5995 03:28:48,767 --> 03:28:49,868 INDEED, IT TURNS OUT TO BE 5996 03:28:49,868 --> 03:28:50,769 SOMETHING OF IMPORTANCE TO THE 5997 03:28:50,769 --> 03:28:53,472 BASIC AND TRANSLATIONAL MISSIONS 5998 03:28:53,472 --> 03:28:57,142 OF NEARLY EVERY ONE OF THE NIH 5999 03:28:57,142 --> 03:28:58,977 INSTITUTES. 6000 03:28:58,977 --> 03:29:03,248 JUST A BACKGROUND ON CELLULAR 6001 03:29:03,248 --> 03:29:06,952 ?ESENESCENCE, IT ONLY APPEARED S 6002 03:29:06,952 --> 03:29:08,620 A REALITY IN THE 1960s WHEN IT 6003 03:29:08,620 --> 03:29:10,055 WAS FIRST NOTED THAT CELLS, 6004 03:29:10,055 --> 03:29:11,490 NORMAL CELLS, NON-MALIGNANT 6005 03:29:11,490 --> 03:29:12,557 CELLS, EVEN IN TISSUE CULTURE, 6006 03:29:12,557 --> 03:29:18,363 HAD A FINITE REPLY KAYTIVE 6007 03:29:18,363 --> 03:29:18,797 CAPACITY. 6008 03:29:18,797 --> 03:29:20,165 THEY DON'T JUST SIT THERE, 6009 03:29:20,165 --> 03:29:20,832 THOUGH, THEY HAVE 6010 03:29:20,832 --> 03:29:22,134 CHARACTERISTICS WHICH ARE AN 6011 03:29:22,134 --> 03:29:25,670 IMPORTANT PART OF THEIR BIOLOGY. 6012 03:29:25,670 --> 03:29:26,972 THEY HAVE NORMAL BIOLOGICAL 6013 03:29:26,972 --> 03:29:28,406 ROLES FOR THINGS SUCH AS WOUND 6014 03:29:28,406 --> 03:29:30,275 HEALING AND EMBRYONIC 6015 03:29:30,275 --> 03:29:30,709 DEVELOPMENT. 6016 03:29:30,709 --> 03:29:32,577 THEY ALSO PLAY A ROLE AS THEY 6017 03:29:32,577 --> 03:29:39,851 ACCUMULATE IN NEARLY ALL PEE ALS 6018 03:29:39,851 --> 03:29:40,619 EXAMINED, CONTRIBUTING TO AGING 6019 03:29:40,619 --> 03:29:41,620 CONDITIONS AND DISEASES. 6020 03:29:41,620 --> 03:29:42,721 THEY'RE VERY RARE SO THEIR 6021 03:29:42,721 --> 03:29:44,923 NUMBERS ARE SMALL, EVEN THOUGH 6022 03:29:44,923 --> 03:29:45,690 THEIR IMPLICATIONS AND 6023 03:29:45,690 --> 03:29:48,326 CONSEQUENCES ARE GREAT, AND THE 6024 03:29:48,326 --> 03:29:49,561 MECHANISMS THAT ARE POSSIBLE FOR 6025 03:29:49,561 --> 03:29:51,429 THE SENESCENCE GOING INTO THIS 6026 03:29:51,429 --> 03:29:53,165 MISSION IN PARTICULAR, ARE NOT 6027 03:29:53,165 --> 03:29:55,700 VERY WELL UNDERSTOOD AT ALL. 6028 03:29:55,700 --> 03:29:58,303 THENCE THE NETWORK WAS LAUNCHED 6029 03:29:58,303 --> 03:29:59,437 FIVE YEARS AGO TO STUDY 6030 03:29:59,437 --> 03:30:00,405 SENESCENT CELLS AND THEIR ROLE 6031 03:30:00,405 --> 03:30:04,042 IN HEALTHY AGING AND DISEASE. 6032 03:30:04,042 --> 03:30:06,011 SO A BIT OF THE IMPACT FIRST. 6033 03:30:06,011 --> 03:30:08,213 I'LL GO THROUGH THE SPECIFIC 6034 03:30:08,213 --> 03:30:09,848 COMPONENTS OF THE PROGRAM, BUT 6035 03:30:09,848 --> 03:30:11,249 THE PRODUCTIVITIES INCLUDE THE 6036 03:30:11,249 --> 03:30:15,420 GENERATION OF SOME 1300 DATASETS 6037 03:30:15,420 --> 03:30:17,055 OVER 780 THEM NOW PUBLISHED. 6038 03:30:17,055 --> 03:30:19,090 MANY OF THE OTHER PROTOCOLS FOR 6039 03:30:19,090 --> 03:30:21,059 STUDY OF SENESCENCE PUBLISHED. 6040 03:30:21,059 --> 03:30:22,928 TO THE RIGHT YOU SEE A SUMMARY 6041 03:30:22,928 --> 03:30:24,896 OF THE TISSUES OF ORIGIN, AND 6042 03:30:24,896 --> 03:30:26,998 THE KINDS OF MULTIPLE OMIC 6043 03:30:26,998 --> 03:30:28,066 ASSAYS THAT HAVE BEEN CARRIED 6044 03:30:28,066 --> 03:30:34,639 OUT TO CHARACTERIZE THESE CELLS. 6045 03:30:34,639 --> 03:30:37,609 THIS IS A NETWORK VISUALIZATION 6046 03:30:37,609 --> 03:30:43,481 OF THE WAY IN WHICH SOME 15 6047 03:30:43,481 --> 03:30:47,719 ORGANS STUDIED SORTED OUT IN 6048 03:30:47,719 --> 03:30:49,888 SENNET AS IT'S BEEN DEFINED OVER 6049 03:30:49,888 --> 03:30:51,523 THESE PAST YEARS. 6050 03:30:51,523 --> 03:30:54,926 IN ADDITION TO IDENTIFYING THE 6051 03:30:54,926 --> 03:30:56,461 SENESCENT CELLS AND THEIR 6052 03:30:56,461 --> 03:30:57,562 HETEROGENEITY, THE PROCESS OF 6053 03:30:57,562 --> 03:30:59,331 DOING SO REQUIRED DEVELOPMENT OF 6054 03:30:59,331 --> 03:31:00,665 NOVEL TOOLS AND TECHNOLOGY, SOME 6055 03:31:00,665 --> 03:31:02,634 OF WHICH ARE LISTED HERE, SO FOR 6056 03:31:02,634 --> 03:31:11,076 EXAMPLE, A RADIO TRACER THAT 6057 03:31:11,076 --> 03:31:13,578 VISUALIZES, HERE AMENABLE NOW TO 6058 03:31:13,578 --> 03:31:15,981 PET AND MRI IMAGING AS WELL AS 6059 03:31:15,981 --> 03:31:18,183 SEVERAL YOU'LL SEE 6060 03:31:18,183 --> 03:31:20,385 BIOINFORMATICS TISSUES, 6061 03:31:20,385 --> 03:31:21,786 TRANSCRIPTOMICS AND SPATIAL 6062 03:31:21,786 --> 03:31:23,121 TRANSCRIPTOMIC TECHNIQUES. 6063 03:31:23,121 --> 03:31:24,789 WHAT I'LL SAY IS REMARKABLE 6064 03:31:24,789 --> 03:31:25,891 THESE PAST FIVE YEARS IS THAT 6065 03:31:25,891 --> 03:31:28,293 THE TECHNIQUES TO DEVELOP THE 6066 03:31:28,293 --> 03:31:31,363 INITIAL STAGE IT'S AT ACTUALLY 6067 03:31:31,363 --> 03:31:32,163 WERE LARGELY A RESULT OF THE 6068 03:31:32,163 --> 03:31:35,200 INITIAL PHASE, AND WHEN WE GO 6069 03:31:35,200 --> 03:31:36,835 FURTHER, ARTIFICIAL INTELLIGENCE 6070 03:31:36,835 --> 03:31:39,838 BARELY CONCEPTUALIZED FIVE YEARS 6071 03:31:39,838 --> 03:31:44,209 AGO AS ADDED ENORMOUSLY TO THE 6072 03:31:44,209 --> 03:31:45,510 PROSPECTS OF WHAT WE'RE 6073 03:31:45,510 --> 03:31:46,978 PROPOSING TO YOU TODAY. 6074 03:31:46,978 --> 03:31:48,847 SO THE IMPACT IN TERMS OF 6075 03:31:48,847 --> 03:31:49,915 PUBLICATIONS, AN EASY THING TO 6076 03:31:49,915 --> 03:31:51,149 MEASURE, YOU CAN SEE IN THE 6077 03:31:51,149 --> 03:31:51,816 FIGURE TO THE LEFT. 6078 03:31:51,816 --> 03:31:54,419 THE NUMBER OF PUBLICATIONS. 6079 03:31:54,419 --> 03:31:58,290 INCREASING TRULY EXPONENTIALLY 6080 03:31:58,290 --> 03:31:59,324 INTO 2024. 6081 03:31:59,324 --> 03:32:00,692 IT INVOLVES SOME VERY HIGH LEVEL 6082 03:32:00,692 --> 03:32:03,228 HIGH PROFILE PUBLICATIONS THAT 6083 03:32:03,228 --> 03:32:04,262 HAVE PROVIDED RECOMMENDATIONS 6084 03:32:04,262 --> 03:32:09,834 FOR HOW TO STUDY AND DETECT 6085 03:32:09,834 --> 03:32:11,870 SENESCENT CELLS, AND THEN THE 6086 03:32:11,870 --> 03:32:13,405 USE OF TECHNIQUES SUCH AS 6087 03:32:13,405 --> 03:32:16,107 SPATIAL MAPPING OF CELLULAR 6088 03:32:16,107 --> 03:32:17,275 SENESCENCE AND THE OPPORTUNITIES 6089 03:32:17,275 --> 03:32:23,748 THAT IT CREATES. 6090 03:32:23,748 --> 03:32:25,483 SO A SUMMARY OF THE PLANNING 6091 03:32:25,483 --> 03:32:26,785 ACTIVITIES WITH REGARD TO THE 6092 03:32:26,785 --> 03:32:28,153 SECOND PHASE, FOCUS GROUPS THAT 6093 03:32:28,153 --> 03:32:29,621 INVOLVE CONSORTIUM PIs IN THE 6094 03:32:29,621 --> 03:32:30,889 FIRST STAGE ITSELF AS WELL AS 6095 03:32:30,889 --> 03:32:33,425 WORKING GROUP MEMBERS, EXPERT 6096 03:32:33,425 --> 03:32:35,727 PANELS CONVENED AND PROGRAM 6097 03:32:35,727 --> 03:32:36,161 CONSULTANTS. 6098 03:32:36,161 --> 03:32:37,829 THE SUMMARY WAS THAT WE NEED TO 6099 03:32:37,829 --> 03:32:39,864 DEFINE THE BIOLOGICAL RELEVANCE 6100 03:32:39,864 --> 03:32:43,001 OF THE SENESCENCE HETEROGENEITY 6101 03:32:43,001 --> 03:32:44,202 WHICH APPEARED IN THIS FIRST 6102 03:32:44,202 --> 03:32:45,203 PHASE AND UNDERSTAND IN TERMS OF 6103 03:32:45,203 --> 03:32:48,173 THE MECHANISMS THAT MEDIATE 6104 03:32:48,173 --> 03:32:49,741 CELLULAR SENESCENCE, ALL AS A 6105 03:32:49,741 --> 03:32:51,810 GUIDE TO THE WAY IN WHICH 6106 03:32:51,810 --> 03:32:53,011 MANIPULATION OF SENESCENT CELLS 6107 03:32:53,011 --> 03:32:56,281 CAN BE USED TO THERAPEUTIC 6108 03:32:56,281 --> 03:32:57,849 ADVANTAGE. 6109 03:32:57,849 --> 03:32:58,717 IMPORTANCE OF DEVELOPING 6110 03:32:58,717 --> 03:33:01,453 PRE-CLINICAL MODELS IN WHICH THE 6111 03:33:01,453 --> 03:33:03,421 VALIDATION OF INTERVENTIONS TO 6112 03:33:03,421 --> 03:33:05,757 AFFECT SENESCENT CELLS CAN BE 6113 03:33:05,757 --> 03:33:06,624 STUDIED. 6114 03:33:06,624 --> 03:33:09,394 STUDY SENESCENT CELLS NOT JUST 6115 03:33:09,394 --> 03:33:10,962 IN HUMAN NORMAL TISSUES BUT IN 6116 03:33:10,962 --> 03:33:12,263 THE CONTEXT OF DISEASE AS WELL, 6117 03:33:12,263 --> 03:33:14,132 ASPECTS OF SENESCENCE AND 6118 03:33:14,132 --> 03:33:15,667 SENESCENT CELLS ARE PATHOGENIC. 6119 03:33:15,667 --> 03:33:17,202 AS I ALLUDED TO, DEVELOPING 6120 03:33:17,202 --> 03:33:18,636 CUTTING EDGE TOOLS INCLUDING AI 6121 03:33:18,636 --> 03:33:20,171 FOR SENESCENT CELL SIGNATURES 6122 03:33:20,171 --> 03:33:21,740 AND PREDICTIONS AND THEN 6123 03:33:21,740 --> 03:33:23,174 IMPORTANTLY TOO, THE CONTEXT OF 6124 03:33:23,174 --> 03:33:25,243 THE COMMON FUND AND OUR BROAD 6125 03:33:25,243 --> 03:33:27,779 DATA INITIATIVES TO STUDY THE 6126 03:33:27,779 --> 03:33:30,215 ENHANCED INTEGRATION OF SENNET 6127 03:33:30,215 --> 03:33:32,350 WITH OTHER SINGLE CELL CONSORTIA 6128 03:33:32,350 --> 03:33:34,819 IN THE COMMON FUND AND WITHOUT 6129 03:33:34,819 --> 03:33:37,589 SO THE HUMAN TUMOR ATLAS, THE 6130 03:33:37,589 --> 03:33:42,727 HUMAN BIOLOGICAL MAP OF SPATIAL 6131 03:33:42,727 --> 03:33:44,863 TEMPORAL EXPRESSION IN NORMAL 6132 03:33:44,863 --> 03:33:48,333 TISSUES AND SOMATIC MOSAICISM, 6133 03:33:48,333 --> 03:33:50,001 ALL OF THESE IN A COMMON DATA 6134 03:33:50,001 --> 03:33:53,204 NETWORK WHICH ALLOWS THE OPTIMAL 6135 03:33:53,204 --> 03:33:54,606 CROSS INFORMATION AND LEVERAGING 6136 03:33:54,606 --> 03:33:56,241 OF THE SEVERAL INITIATIVES 6137 03:33:56,241 --> 03:34:02,881 INCLUDING SENNET. 6138 03:34:02,881 --> 03:34:04,315 SO PORTFOLIO ANALYSIS WAS PART 6139 03:34:04,315 --> 03:34:05,183 OF THE SURVEY OF WHERE WE'VE 6140 03:34:05,183 --> 03:34:08,119 COME FROM. 6141 03:34:08,119 --> 03:34:10,288 FOR 2015 THROUGH 2024, IN THESE 6142 03:34:10,288 --> 03:34:13,925 YEARS, IF WE LOOKED AT THE 6143 03:34:13,925 --> 03:34:16,261 TOPICS WHICH WERE SUBJECT OF 6144 03:34:16,261 --> 03:34:19,097 SENNET STAGE ONE, SO CELLULAR 6145 03:34:19,097 --> 03:34:20,198 SENESCENCE, SINGLE CELL SPATIAL 6146 03:34:20,198 --> 03:34:22,100 TISSUE MAPPING OF THE 29 AWARDS 6147 03:34:22,100 --> 03:34:24,169 FROM NIH IN THAT TIME, 22 WERE 6148 03:34:24,169 --> 03:34:27,605 IN SENN ET, TO GIVE AN IDEA OF 6149 03:34:27,605 --> 03:34:28,807 WHAT A PROFOUND IMPACT THIS 6150 03:34:28,807 --> 03:34:30,675 INITIATIVE HAS HAD IN 6151 03:34:30,675 --> 03:34:31,342 ACCELERATING RESEARCH IN THIS 6152 03:34:31,342 --> 03:34:32,577 AREA, THE SAME HOLDS TRUE FOR 6153 03:34:32,577 --> 03:34:33,678 THE OTHER AREAS OF RESEARCH 6154 03:34:33,678 --> 03:34:34,546 AROUND SENESCENCE. 6155 03:34:34,546 --> 03:34:38,883 SO ALREADY, THIS SENNET HAS 6156 03:34:38,883 --> 03:34:40,952 PERFORMED ITS INITIAL TASK IN 6157 03:34:40,952 --> 03:34:42,387 PROVIDING THE FIELD WITH A 6158 03:34:42,387 --> 03:34:46,024 DYNAMIC BEGINNING, THE TOOLS AND 6159 03:34:46,024 --> 03:34:54,132 KAY DATABASES ON WHICH TO PROCE. 6160 03:34:54,132 --> 03:34:58,236 THE ANALYSIS AND INPUT OF 6161 03:34:58,236 --> 03:35:01,973 VARIOUS EXPERT CONVENINGS 6162 03:35:01,973 --> 03:35:03,508 CONCLUDED THAT SENNET INVESTMENT 6163 03:35:03,508 --> 03:35:05,276 IS NEEDED FIRST TO UNDERSTAND 6164 03:35:05,276 --> 03:35:07,011 THE HETEROGENEITY -- BEYOND WHAT 6165 03:35:07,011 --> 03:35:09,080 WAS EXPECTED, HETEROGENEITY IN 6166 03:35:09,080 --> 03:35:11,316 TERMS OF BIOCHEMICAL SIGNATURES 6167 03:35:11,316 --> 03:35:13,618 AT A CELLULAR LEVEL, BIOLOGY OF 6168 03:35:13,618 --> 03:35:14,953 SENESCENCE AT A SINGLE CELL 6169 03:35:14,953 --> 03:35:16,321 LEVEL, AGAIN IN NORMAL AND 6170 03:35:16,321 --> 03:35:19,491 DISEASE STATE STATES TO UNCOVERD 6171 03:35:19,491 --> 03:35:21,559 VALIDATE BIOMARKERS THAT CAN BE 6172 03:35:21,559 --> 03:35:24,129 USED IN ULTIMATELY CLINICAL 6173 03:35:24,129 --> 03:35:24,996 MODELS, DEVELOP THE TWO 6174 03:35:24,996 --> 03:35:26,197 TECHNOLOGIES TO DO SO, AND TO 6175 03:35:26,197 --> 03:35:27,332 INTEGRATE THE RESULTS OF STAGE 6176 03:35:27,332 --> 03:35:28,433 ONE WITH WHAT THE MAPPING 6177 03:35:28,433 --> 03:35:30,335 EFFORTS WILL BE IN STAGE TWO TO 6178 03:35:30,335 --> 03:35:35,140 JEB RGENERATE A SEARCHABLE ATLAF 6179 03:35:35,140 --> 03:35:37,342 SENESCENT CELLS. 6180 03:35:37,342 --> 03:35:43,014 SO SENNET GOALS AND INITIATIVES, 6181 03:35:43,014 --> 03:35:44,616 TO UNDERSTAND THE BIOLOGICAL 6182 03:35:44,616 --> 03:35:46,751 RELEVANCE OF SENESCENT CELLS AND 6183 03:35:46,751 --> 03:35:49,487 HETEROGENEITY, TO IDENTIFY AND 6184 03:35:49,487 --> 03:35:50,855 VALIDATE DIVERSE SENESCENT 6185 03:35:50,855 --> 03:35:53,091 SIGNATURES IN HUMAN BIOSPECIMENS 6186 03:35:53,091 --> 03:35:55,160 AND INFORM SENOTHERAPEUTIC 6187 03:35:55,160 --> 03:35:56,461 STRATEGIES FOR HUMAN HEALTH, ALL 6188 03:35:56,461 --> 03:35:57,729 BASED ON THE FINDING THAT 6189 03:35:57,729 --> 03:35:59,130 SENESCENT CELLS AND THEIR 6190 03:35:59,130 --> 03:36:00,031 MANIPULATION OF ANIMAL MODELS 6191 03:36:00,031 --> 03:36:01,533 SEEM TO HAVE IMPACT ON MULTIPLE 6192 03:36:01,533 --> 03:36:03,034 DISEASES AND CONDITIONS AND SO 6193 03:36:03,034 --> 03:36:05,003 THE INTERVENTIONS ON SENESCENT 6194 03:36:05,003 --> 03:36:06,437 CELLS MIGHT INDEED HAVE IMPACTS 6195 03:36:06,437 --> 03:36:09,240 ON MULTIPLE OF THE CONTRIBUTIONS 6196 03:36:09,240 --> 03:36:09,974 TO HUMAN HEALTH. 6197 03:36:09,974 --> 03:36:11,609 THE STAGE TWO INITIATIVE ALSO BE 6198 03:36:11,609 --> 03:36:12,810 DISCOVERY, MAPPING AND 6199 03:36:12,810 --> 03:36:15,213 VALIDATION CENTERS. 6200 03:36:15,213 --> 03:36:17,015 THE SENESCENCE TECHNOLOGY 6201 03:36:17,015 --> 03:36:18,883 PROJECTS TO FURTHER DEVELOP 6202 03:36:18,883 --> 03:36:20,185 TECHNOLOGY NEEDED TO STUDY 6203 03:36:20,185 --> 03:36:22,420 SENESCENT CELLS IN VIVO AS WELL 6204 03:36:22,420 --> 03:36:23,288 AS IN VITRO AND A DATA 6205 03:36:23,288 --> 03:36:25,690 COORDINATION OF INTEGRATION AND 6206 03:36:25,690 --> 03:36:26,558 ORGANIZATIONAL CENTER TO MAKE 6207 03:36:26,558 --> 03:36:28,893 THESE MAXIMALLY AVAILABLE AND 6208 03:36:28,893 --> 03:36:29,627 LEVERAGABLE IN THE BROADER 6209 03:36:29,627 --> 03:36:34,365 RESEARCH COMMUNITY. 6210 03:36:34,365 --> 03:36:36,000 SO THE FIRST INITIATIVE 6211 03:36:36,000 --> 03:36:37,902 DISCOVERY AND MAPPING WILL BE A 6212 03:36:37,902 --> 03:36:39,871 SERIES OF MAPPING VALIDATION 6213 03:36:39,871 --> 03:36:41,105 CENTERS, WHICH WILL USE STATE OF 6214 03:36:41,105 --> 03:36:42,407 THE ART TECHNIQUES, MANY OF 6215 03:36:42,407 --> 03:36:43,575 WHICH HAVE BEEN DEVELOPED BY THE 6216 03:36:43,575 --> 03:36:45,510 FIRST PHASE OF THIS INITIATIVE 6217 03:36:45,510 --> 03:36:48,246 TO DEFINE ORGAN SPECIFIC 6218 03:36:48,246 --> 03:36:50,982 SENOTYPES AND THEIR FUNCTION IN 6219 03:36:50,982 --> 03:36:51,683 HEALTH DEVELOPMENT AND IN 6220 03:36:51,683 --> 03:36:52,884 DISEASE CONDITIONS, AND 6221 03:36:52,884 --> 03:36:54,085 IMPORTANTLY TO IDENTIFY 6222 03:36:54,085 --> 03:36:55,453 PRE-CLINICAL MODELS WHICH ALLOW 6223 03:36:55,453 --> 03:36:56,788 THE PERTURBATION AND INDUCTIONS 6224 03:36:56,788 --> 03:36:58,756 OF SENESCENCE MODULATION OF 6225 03:36:58,756 --> 03:37:00,491 SENESCENCE TO TEST AND TO 6226 03:37:00,491 --> 03:37:03,061 VALIDATE SENOSPARE PEW PUGH 6227 03:37:03,061 --> 03:37:06,331 TICKS AND STRATEGIES TOWARDS 6228 03:37:06,331 --> 03:37:07,298 TRANSLATIONAL AND CLINICAL 6229 03:37:07,298 --> 03:37:10,001 APPLICATION. 6230 03:37:10,001 --> 03:37:11,736 SECOND PHASE TO USE INTEGRATED 6231 03:37:11,736 --> 03:37:13,371 SYSTEMS BIOLOGY APPROACHES THAT 6232 03:37:13,371 --> 03:37:14,739 LEVERAGE MULTIPLE SCIENTIFIC 6233 03:37:14,739 --> 03:37:15,840 DISCIPLINES THAT WILL BRING TO 6234 03:37:15,840 --> 03:37:17,475 BEAR ALL OF THE FINDINGS FROM 6235 03:37:17,475 --> 03:37:20,111 THE BASIC SCIENCE TO ADVANCE 6236 03:37:20,111 --> 03:37:21,679 CURRENT UNDERSTANDING AND 6237 03:37:21,679 --> 03:37:23,915 RELEVANCE TO SENESCENCE 6238 03:37:23,915 --> 03:37:24,649 HETEROGENEITY, TO DEVELOP 6239 03:37:24,649 --> 03:37:25,883 TECHNOLOGIES AND MULTI-SCALE 6240 03:37:25,883 --> 03:37:26,985 MODELS TO DETERMINE CELLULAR 6241 03:37:26,985 --> 03:37:29,020 SENESCENCE AND IMPORTANTLY IN 6242 03:37:29,020 --> 03:37:30,955 VIVO OUTCOMES, TO USE 6243 03:37:30,955 --> 03:37:31,723 DEVELOPMENTAL COMPUTATIONAL 6244 03:37:31,723 --> 03:37:33,758 TOOLS SUCH AS THE AI THAT I 6245 03:37:33,758 --> 03:37:34,859 MENTIONED SEVERAL TIMES IN 6246 03:37:34,859 --> 03:37:39,464 CARRYING OUT THIS TRANSLATION. 6247 03:37:39,464 --> 03:37:40,231 THIRD COMPONENT INITIATIVE 6248 03:37:40,231 --> 03:37:41,799 THREE, TO HAVE A DATA 6249 03:37:41,799 --> 03:37:42,667 COORDINATION AND INTEGRATION 6250 03:37:42,667 --> 03:37:45,803 CENTER THAT WILL MAKE AVAILABLE 6251 03:37:45,803 --> 03:37:47,438 THE OUTCOMES OF THESE DATA TO 6252 03:37:47,438 --> 03:37:48,539 THE RESEARCH PUBLIC AND AS I 6253 03:37:48,539 --> 03:37:50,174 NOTED AT THE OUTSET IN 6254 03:37:50,174 --> 03:37:50,842 COLLABORATION WITH SOME OF THE 6255 03:37:50,842 --> 03:37:54,612 OTHER CELLULAR LARGE SCALE DATA 6256 03:37:54,612 --> 03:37:56,114 INITIATIVES THAT ARE IN PROGRESS 6257 03:37:56,114 --> 03:37:58,416 ALL IN GENERATING INTERACTIVE 6258 03:37:58,416 --> 03:37:59,984 ATLASES THAT WILL MAXIMIZE THE 6259 03:37:59,984 --> 03:38:05,723 IMPACT OF THE SEVERAL EFFORTS. 6260 03:38:05,723 --> 03:38:07,825 PROPOSAL MEETS COMMON FUND 6261 03:38:07,825 --> 03:38:09,294 CRITERIA, REMAINS NOVEL THE WAY 6262 03:38:09,294 --> 03:38:10,461 IT'S CONTRIBUTED TO THE FIELD 6263 03:38:10,461 --> 03:38:10,928 ALREADY. 6264 03:38:10,928 --> 03:38:12,897 HAS TRANSFORMED THE IDEA OF 6265 03:38:12,897 --> 03:38:14,732 MOVING SENESCENCE RESEARCH 6266 03:38:14,732 --> 03:38:16,901 FORWARD INTO THERAPEUTIC 6267 03:38:16,901 --> 03:38:17,935 TRANSLATIONS. 6268 03:38:17,935 --> 03:38:18,603 HAS CATALYZED THIS WORK AS YOU 6269 03:38:18,603 --> 03:38:21,139 CAN SEE BY THE ENORMOUS IMPACT 6270 03:38:21,139 --> 03:38:25,410 THAT THE SENNET STUDIES THEM 6271 03:38:25,410 --> 03:38:27,178 SELVES HAVE IT ON THE FIELD, 6272 03:38:27,178 --> 03:38:29,480 GIVEN BY THE SAME GOALS THAT 6273 03:38:29,480 --> 03:38:32,917 MOTIVATED TO BEGIN WITH AND 6274 03:38:32,917 --> 03:38:34,085 SYNERGIZE ACROSS INSTITUTES, 6275 03:38:34,085 --> 03:38:35,853 CENTERS AND OFFICES ACROSS THE 6276 03:38:35,853 --> 03:38:41,125 ENTIRE LIFESPAN. 6277 03:38:41,125 --> 03:38:43,895 SO THE SENESCENCE SENNET STAGE 6278 03:38:43,895 --> 03:38:45,930 II BUDGET ILLUSTRATED HERE, THE 6279 03:38:45,930 --> 03:38:46,998 FIRST COMPONENT, THE DISCOVERY 6280 03:38:46,998 --> 03:38:49,901 AND MAPPING VALIDATION CENTER, 6281 03:38:49,901 --> 03:38:52,103 APPROXIMATELY 8 TO 10 OF THEM AT 6282 03:38:52,103 --> 03:38:53,237 ABOUT $2 MILLION EACH FOR 6283 03:38:53,237 --> 03:38:54,539 $20 MILLION PER YEAR FOR THE 6284 03:38:54,539 --> 03:38:55,540 FIVE-YEAR DURATION OF THE 6285 03:38:55,540 --> 03:38:57,942 PROPOSED EXTENSION. 6286 03:38:57,942 --> 03:39:00,111 THE TECHNOLOGY CENTERS AT 6287 03:39:00,111 --> 03:39:01,913 APPROXIMATELY A MILLION EACH, 6288 03:39:01,913 --> 03:39:03,381 ANOTHER 6 TO 8 OF THESE CENTERS, 6289 03:39:03,381 --> 03:39:05,883 AND THEN A COORDINATING CENTER 6290 03:39:05,883 --> 03:39:07,118 OF $3.4 MILLION SO THE OVERALL 6291 03:39:07,118 --> 03:39:08,619 PROPOSAL WITH ADMINISTRATIVE 6292 03:39:08,619 --> 03:39:10,555 EXPENSES IS APPROXIMATELY 6293 03:39:10,555 --> 03:39:11,589 $30 MILLION PER YEAR FOR EACH OF 6294 03:39:11,589 --> 03:39:17,695 FIVE YEARS. 6295 03:39:17,695 --> 03:39:21,232 THE DELIVERABLES WILL BE CURATED 6296 03:39:21,232 --> 03:39:24,969 SEARCHABLE AT LESSES OF SENOTYPE 6297 03:39:24,969 --> 03:39:26,137 BIOLOGY IN HEALTH AND DISEASE, 6298 03:39:26,137 --> 03:39:27,505 IMPROVED ANIMAL AND RELEVANT 6299 03:39:27,505 --> 03:39:29,374 PRE-CLINICAL MODELS TO 6300 03:39:29,374 --> 03:39:31,342 ACCELERATE SENOTHERAPEUTIC 6301 03:39:31,342 --> 03:39:32,510 INTERVENTIONS AND INNOVATIVE 6302 03:39:32,510 --> 03:39:34,879 TOOLS AND TECHNOLOGIES TO 6303 03:39:34,879 --> 03:39:39,250 PREDICT BIOLOGICAL OUTCOMES OF 6304 03:39:39,250 --> 03:39:42,420 INTERVENTIONS IN VIVO. 6305 03:39:42,420 --> 03:39:43,454 ACTION WE'RE ASKING OF THE 6306 03:39:43,454 --> 03:39:45,823 COUNCIL IS TO CONSIDER FOR 6307 03:39:45,823 --> 03:39:47,859 APPROVAL EXTENSION OF THIS 6308 03:39:47,859 --> 03:39:50,228 CONCEPT FROM A VERY PRODUCTIVE 6309 03:39:50,228 --> 03:39:52,530 PHASE 1 INTO THE SECOND STAGE, 6310 03:39:52,530 --> 03:39:54,499 STAGE TWO OF CELLULAR SENESCENCE 6311 03:39:54,499 --> 03:39:54,732 PROGRAM. 6312 03:39:54,732 --> 03:39:56,000 I'D BE HAPPY TO ADDRESS ANY 6313 03:39:56,000 --> 03:39:56,667 QUESTIONS YOU MIGHT HAVE, AND 6314 03:39:56,667 --> 03:39:57,435 THANK YOU FOR THE OPPORTUNITY TO 6315 03:39:57,435 --> 03:39:59,637 TALK WITH YOU. 6316 03:39:59,637 --> 03:40:01,739 >> THANK YOU, RICHARD. 6317 03:40:01,739 --> 03:40:02,840 AND I MUST JUST TAKE A QUICK 6318 03:40:02,840 --> 03:40:04,942 SECOND TO APOLOGIZE FOR 6319 03:40:04,942 --> 03:40:07,245 MISSPEAKING DURING THE INTRO. 6320 03:40:07,245 --> 03:40:09,180 THE ADJECTIVE "NEW" SHOULD 6321 03:40:09,180 --> 03:40:10,281 OBVIOUSLY BE APPLIED TO ME AND 6322 03:40:10,281 --> 03:40:11,149 NOT TO THIS PROGRAM. 6323 03:40:11,149 --> 03:40:13,885 AND SO I REALLY APPRECIATE YOU 6324 03:40:13,885 --> 03:40:15,586 GIVING US SUCH A DETAILED 6325 03:40:15,586 --> 03:40:16,921 OVERVIEW OF THE TRANSFORMATIVE 6326 03:40:16,921 --> 03:40:17,989 IMPACT THAT IT'S ALREADY HAD AND 6327 03:40:17,989 --> 03:40:20,158 THE PROPOSAL TO MOVE TO STAGE 6328 03:40:20,158 --> 03:40:20,658 II. 6329 03:40:20,658 --> 03:40:22,293 SO DR. LLOYD, WOULD YOU PLEASE 6330 03:40:22,293 --> 03:40:23,294 SHARE ANY COMMENTS WITH THE 6331 03:40:23,294 --> 03:40:24,228 COUNCIL. 6332 03:40:24,228 --> 03:40:24,829 >> SURE. 6333 03:40:24,829 --> 03:40:25,163 THANKS. 6334 03:40:25,163 --> 03:40:26,397 YOU KNOW, IN THE INTEREST OF 6335 03:40:26,397 --> 03:40:28,399 TIME, NORMALLY I WOULD PROVIDE A 6336 03:40:28,399 --> 03:40:30,368 SUMMARY OF WHAT DR. HODES 6337 03:40:30,368 --> 03:40:31,836 PRESENTED BUT I THINK WE ALL GET 6338 03:40:31,836 --> 03:40:34,806 IT AND JUST TO CUT TO THE CHASE. 6339 03:40:34,806 --> 03:40:36,140 I HAVE A FEW QUESTIONS IF YOU 6340 03:40:36,140 --> 03:40:37,308 DON'T MIND. 6341 03:40:37,308 --> 03:40:39,010 FIRST CAN YOU CLARIFY FOR ME, 6342 03:40:39,010 --> 03:40:43,181 BECAUSE ONE OF YOUR SLIDES SHOWS 6343 03:40:43,181 --> 03:40:48,186 A PORTFOLIO ANALYSIS FROM 2015 6344 03:40:48,186 --> 03:40:51,456 TO 2024 ASSOCIATED WITH SENNET 6345 03:40:51,456 --> 03:40:51,989 GRANTS DURING THAT TIME. 6346 03:40:51,989 --> 03:40:54,158 SO I NEED TO GET CLARIFICATION, 6347 03:40:54,158 --> 03:40:55,159 NORMALLY COMMON FUND PROGRAMS 6348 03:40:55,159 --> 03:40:56,561 ARE 10 YEARS IN LENGTH. 6349 03:40:56,561 --> 03:40:58,429 HAVE YOU ALREADY HAD 10 YEARS 6350 03:40:58,429 --> 03:40:59,430 FOR STAGE ONE? 6351 03:40:59,430 --> 03:41:01,866 AND THIS IS NOW THE NEXT FIVE -- 6352 03:41:01,866 --> 03:41:04,068 ANOTHER FIVE YEARS, OR CAN YOU 6353 03:41:04,068 --> 03:41:05,269 EXPLAIN THAT SLIDE? 6354 03:41:05,269 --> 03:41:06,003 I DON'T UNDERSTAND. 6355 03:41:06,003 --> 03:41:07,405 >> THANK YOU FOR THE QUESTION. 6356 03:41:07,405 --> 03:41:08,539 I APOLOGIZE, I SEE THE CONFUSION 6357 03:41:08,539 --> 03:41:10,575 IN THE SLIDE. 6358 03:41:10,575 --> 03:41:12,944 THE SENNET INITIATIVE BEGAN FIVE 6359 03:41:12,944 --> 03:41:14,779 YEARS AGO, AND THE PROPOSAL IS 6360 03:41:14,779 --> 03:41:15,980 FOR AN EXTENSION FOR THE NEXT 6361 03:41:15,980 --> 03:41:16,314 FIVE YEARS. 6362 03:41:16,314 --> 03:41:20,318 THE LONGER TIME FRAME YOU SAW 6363 03:41:20,318 --> 03:41:23,054 THERE WATI WAS THE TIME FRAME OR 6364 03:41:23,054 --> 03:41:24,689 WHICH LITERATURE WAS SURVEYED 6365 03:41:24,689 --> 03:41:28,192 FOR TOPICS RELATED TO SENNET 6366 03:41:28,192 --> 03:41:30,361 OVER THAT ENTIRE 10-YEAR 6367 03:41:30,361 --> 03:41:31,162 HISTORY. 6368 03:41:31,162 --> 03:41:34,565 THE SENNET SUPPORTED STUDIES, A 6369 03:41:34,565 --> 03:41:35,633 VAST MAJORITY OF RESEARCH IN 6370 03:41:35,633 --> 03:41:36,334 THAT AREA. 6371 03:41:36,334 --> 03:41:37,535 SO IT'S BEEN YEARS OF RESEARCH 6372 03:41:37,535 --> 03:41:39,337 BUT VERY LITTLE OF IT ACTIVE 6373 03:41:39,337 --> 03:41:43,074 THAT PRECEDED THE FIVE YEARS OF 6374 03:41:43,074 --> 03:41:44,575 STAGE ONE OF THIS SENESCENCE 6375 03:41:44,575 --> 03:41:45,610 PROGRAM. 6376 03:41:45,610 --> 03:41:46,944 >> OKAY, THANK YOU FOR CLEARING 6377 03:41:46,944 --> 03:41:47,311 THAT UP. 6378 03:41:47,311 --> 03:41:49,413 THAT WAS A MAJOR CONFUSION ON MY 6379 03:41:49,413 --> 03:41:49,914 PART. 6380 03:41:49,914 --> 03:41:50,882 THE SECOND THING IS ON ONE OF 6381 03:41:50,882 --> 03:41:55,253 YOUR SLIDES, YOU SHOWED THE STIJ 6382 03:41:55,253 --> 03:41:56,988 ONE IMPACT, BUT IT APPEARED TO 6383 03:41:56,988 --> 03:41:59,724 ME, THERE WAS REALLY NO COMPLETE 6384 03:41:59,724 --> 03:42:02,326 DATASET FOR ANY OF THE TISSUES 6385 03:42:02,326 --> 03:42:03,728 THAT WERE STUDIED. 6386 03:42:03,728 --> 03:42:06,564 WAS THAT THE GOAL OF THE FIRST 6387 03:42:06,564 --> 03:42:06,898 PHASE? 6388 03:42:06,898 --> 03:42:09,700 IT LOOKED HIGHLY VARIABLE. 6389 03:42:09,700 --> 03:42:10,735 SO I WONDER IF YOU COULD COMMENT 6390 03:42:10,735 --> 03:42:11,736 ON THAT. 6391 03:42:11,736 --> 03:42:18,476 >> YES, S THE SLIDE ILLUSTRATES 6392 03:42:18,476 --> 03:42:21,312 THE NUMBER OF STUDIES THAT WERE 6393 03:42:21,312 --> 03:42:22,613 PUBLISHED, AS WELL AS THE NUMBER 6394 03:42:22,613 --> 03:42:24,248 UNDER QC OR QUALITY ASSESSMENT. 6395 03:42:24,248 --> 03:42:25,816 IN THESE FIRST YEARS, THE 6396 03:42:25,816 --> 03:42:26,984 SUCCESS HAS BEEN TO GENERATE 6397 03:42:26,984 --> 03:42:29,153 THESE LARGE DATABASES, AND 6398 03:42:29,153 --> 03:42:30,588 PROVIDE THEIR ABILITY TO THE 6399 03:42:30,588 --> 03:42:33,424 PUBLIC NOW FOR FULL ANALYSES. 6400 03:42:33,424 --> 03:42:36,093 SSO THE DATA ARE SO EXTENSIVE 6401 03:42:36,093 --> 03:42:37,361 THAT AT THE END OF FIVE YEARS, 6402 03:42:37,361 --> 03:42:39,063 IT'S BEEN AN EXTENSIVE 6403 03:42:39,063 --> 03:42:40,031 COLLECTION, THE ANALYSES IS NOW 6404 03:42:40,031 --> 03:42:41,365 BEING CARRIED OUT BY THE 6405 03:42:41,365 --> 03:42:44,502 MULTIPLE OW OMICS YOU SAW IN TH. 6406 03:42:44,502 --> 03:42:45,970 SO THE SPECIMENS ARE COLLECTED 6407 03:42:45,970 --> 03:42:47,572 AND NOW THE IN PROGRESSOR 6408 03:42:47,572 --> 03:42:49,407 MULTIPLE OMIC DIMENSIONS OR 6409 03:42:49,407 --> 03:42:50,107 STRATEGIES. 6410 03:42:50,107 --> 03:42:51,375 >> OKAY. 6411 03:42:51,375 --> 03:42:53,210 SO THAT TABLE IS, THEREFORE, 6412 03:42:53,210 --> 03:42:55,279 INCOMPLETE BECAUSE THE ANALYSIS 6413 03:42:55,279 --> 03:42:55,546 CONTINUES. 6414 03:42:55,546 --> 03:42:55,880 >> CORRECT. 6415 03:42:55,880 --> 03:42:58,215 >> MY CONCERN IS THAT UNLESS YOU 6416 03:42:58,215 --> 03:43:00,017 HAVE A COMPLETE DATASET FOR ALL 6417 03:43:00,017 --> 03:43:02,053 THE TISSUES, IT WILL BE IN THE 6418 03:43:02,053 --> 03:43:03,421 FIRST PHASE IN WHICH YOU'RE 6419 03:43:03,421 --> 03:43:04,956 DEVELOPING BIOMARKERS AND YOU 6420 03:43:04,956 --> 03:43:06,357 DEVELOP NEW TOOLS, YOU KIND OF 6421 03:43:06,357 --> 03:43:07,858 NEED THAT TO MOVE ON TO THE NEXT 6422 03:43:07,858 --> 03:43:11,028 PHASE IN WHICH YOU'RE LOOKING AT 6423 03:43:11,028 --> 03:43:12,430 BIOLOGICAL NETWORKS IN BOTH 6424 03:43:12,430 --> 03:43:13,731 HEALTHY TISSUE AND DISEASED 6425 03:43:13,731 --> 03:43:16,934 TISSUE AND SO ON. 6426 03:43:16,934 --> 03:43:18,202 >> VERY WELL TAKEN. 6427 03:43:18,202 --> 03:43:21,372 AND IN FACT, TO BE EVEN MORE 6428 03:43:21,372 --> 03:43:22,773 STRAYED FORWARD ABOUT IT, THE 6429 03:43:22,773 --> 03:43:24,508 PHASES ARE DYNAMIC, AREN'T THEY? 6430 03:43:24,508 --> 03:43:25,810 SO WE'LL CONTINUE TO HAVE MORE 6431 03:43:25,810 --> 03:43:27,011 AND MORE ANALYSES WITH THE 6432 03:43:27,011 --> 03:43:28,145 ASSAYS WE KNOW AND THE ASSAYS 6433 03:43:28,145 --> 03:43:29,947 THAT WILL BE DEVELOPED, AND AS 6434 03:43:29,947 --> 03:43:31,682 WE HAVE INCREASING INFORMATION, 6435 03:43:31,682 --> 03:43:32,917 THAT WILL ALL FEED INTO THE 6436 03:43:32,917 --> 03:43:36,387 ABILITY OF PHASE TWO TO 6437 03:43:36,387 --> 03:43:38,022 TRANSLATE THAT INTO NEXT STEPS 6438 03:43:38,022 --> 03:43:39,123 OF TRANSLATION AND CLINICAL 6439 03:43:39,123 --> 03:43:39,690 APPLICATION. 6440 03:43:39,690 --> 03:43:41,225 >> OKAY. 6441 03:43:41,225 --> 03:43:44,095 LASTLY, QUESTION ON THE SCIENCE 6442 03:43:44,095 --> 03:43:46,163 THEN. 6443 03:43:46,163 --> 03:43:47,465 THERE'S OBVIOUSLY A FOCUS ON 6444 03:43:47,465 --> 03:43:49,200 SENESCENCE BUT I WAS CURIOUS AS 6445 03:43:49,200 --> 03:43:50,234 TO WHETHER THERE WILL BE ANY 6446 03:43:50,234 --> 03:43:51,769 TYPE OF INVESTIGATION INTO THE 6447 03:43:51,769 --> 03:43:52,837 RELATIONSHIP BETWEEN A CELL 6448 03:43:52,837 --> 03:43:54,705 ENTERING SENESCENCE VERSUS ONE 6449 03:43:54,705 --> 03:43:57,975 THAT ENTERS APOPTOSIS, WHICH IS 6450 03:43:57,975 --> 03:44:03,848 OBVIOUSLY DEATH OF A DEATH OF , 6451 03:44:03,848 --> 03:44:08,653 IRREVERSIBLE, VERSUS A CELL THAT 6452 03:44:08,653 --> 03:44:10,021 REACHES -- I WONDER IF THERE 6453 03:44:10,021 --> 03:44:11,389 WILL BE AN ANALYSIS OF THAT AND 6454 03:44:11,389 --> 03:44:12,690 FINDING WAYS OR PERHAPS 6455 03:44:12,690 --> 03:44:14,725 EXPLAINING MECHANISMS OF HOW A 6456 03:44:14,725 --> 03:44:15,726 CELL MAY POTENTIALLY MOVE 6457 03:44:15,726 --> 03:44:16,827 BETWEEN THOSE DIFFERENT PHASES. 6458 03:44:16,827 --> 03:44:18,229 >> THAT'S A GREAT QUESTION. 6459 03:44:18,229 --> 03:44:20,431 AND THERE IS A LOT OF ACTIVE 6460 03:44:20,431 --> 03:44:21,732 RESEARCH BEING PROPOSED AND 6461 03:44:21,732 --> 03:44:23,668 BEING FUNDED ADDRESSING JUST 6462 03:44:23,668 --> 03:44:25,136 THOSE QUESTIONS IN A NUMBER OF 6463 03:44:25,136 --> 03:44:26,604 CELL TYPES. 6464 03:44:26,604 --> 03:44:27,605 SO CELLULAR SENESCENCE WAS 6465 03:44:27,605 --> 03:44:29,140 INITIALLY DEFINED AS 6466 03:44:29,140 --> 03:44:29,473 IRREVERSIBLE. 6467 03:44:29,473 --> 03:44:35,946 YOU MAY NOTE NOW MORE OFTEN IT'S 6468 03:44:35,946 --> 03:44:37,214 THOUGHT AS MORE DURABLE BECAUSE 6469 03:44:37,214 --> 03:44:38,416 THERE MAY BE CONDITIONS UNDER 6470 03:44:38,416 --> 03:44:40,384 WHICH IT CAN BE REVERSED. 6471 03:44:40,384 --> 03:44:42,753 APOPTOSIS AS YOU SAID IS CELL 6472 03:44:42,753 --> 03:44:44,488 DEATH, BY DEFINITION, 6473 03:44:44,488 --> 03:44:46,023 IRREVERSIBLE, AND QUIESCENCE, 6474 03:44:46,023 --> 03:44:48,192 YES IS A STAGE OF RELATIVE 6475 03:44:48,192 --> 03:44:49,393 INACTIVITY, BUT WHICH IS MORE 6476 03:44:49,393 --> 03:44:51,696 EASILY REVERSIBLE. 6477 03:44:51,696 --> 03:44:53,097 CELLULAR SENESCENCE IS NOT A 6478 03:44:53,097 --> 03:44:55,599 STAGE OF DORMANCY AND PERHAPS I 6479 03:44:55,599 --> 03:44:57,802 COULD HAVE EMPHASIZED THAT MO 6480 03:44:57,802 --> 03:45:00,271 BUT THE PHYSIOLOGIC METABOLIC 6481 03:45:00,271 --> 03:45:00,838 ACTIVITY OF HE? 6482 03:45:00,838 --> 03:45:10,414 SEPTESENESCENT CELLS, THESECRETF 6483 03:45:10,414 --> 03:45:11,515 SECRETEOME, THE CELLS DON'T JUST 6484 03:45:11,515 --> 03:45:12,817 STOP CAN I VIEDING AND SIT THERE 6485 03:45:12,817 --> 03:45:14,285 IN SMALL NUMBERS. 6486 03:45:14,285 --> 03:45:15,619 THEY'RE HIGHLY ACTIVE. 6487 03:45:15,619 --> 03:45:17,822 QUIESCENT CELLS ARE COMMONLY 6488 03:45:17,822 --> 03:45:19,890 REGARDED AS CELLS WHICH ARE TRUE 6489 03:45:19,890 --> 03:45:23,828 LIE FUNCTIONALLY QUIESCENT 6490 03:45:23,828 --> 03:45:25,162 BUT -- AS YOU POINT OUT THE 6491 03:45:25,162 --> 03:45:26,564 DETERMINANTS THAT PROTECT 6492 03:45:26,564 --> 03:45:28,966 SENESCENT CELLS, ONE OF THE 6493 03:45:28,966 --> 03:45:29,533 CHARACTERISTICS OF SENESCENT 6494 03:45:29,533 --> 03:45:31,035 CELLS IS THE FACT THAT THEY ARE 6495 03:45:31,035 --> 03:45:33,137 RESISTANT TO APOPTOSIS AND ONE 6496 03:45:33,137 --> 03:45:34,305 OF THE STRATEGIES FOR 6497 03:45:34,305 --> 03:45:38,342 ELIMINATING THOSE CELLS I HAS TO 6498 03:45:38,342 --> 03:45:40,711 BLOCK THEM FROM THE PATHWAY OF 6499 03:45:40,711 --> 03:45:41,045 APOPTOSIS. 6500 03:45:41,045 --> 03:45:42,446 SO MORE IS KNOWN ABOUT THE 6501 03:45:42,446 --> 03:45:43,781 CHOICE POINTS BETWEEN DEATH AND 6502 03:45:43,781 --> 03:45:44,982 PREVENTION OF DEATH AND 6503 03:45:44,982 --> 03:45:47,551 PRESERVATION OF THE SENESCENCE 6504 03:45:47,551 --> 03:45:48,119 BEING INTACT. 6505 03:45:48,119 --> 03:45:49,854 >> THANK YOU, DR. HODES. 6506 03:45:49,854 --> 03:45:51,489 THE PHASE ONE LOOKS LIKES IT'S 6507 03:45:51,489 --> 03:45:55,426 BEEN VERY, VERY PRODUCTIVE OR 6508 03:45:55,426 --> 03:45:56,393 SUCCESSFUL, CONTINUE TO WORK ON 6509 03:45:56,393 --> 03:45:58,929 SOME OF THOSE DATASETS. 6510 03:45:58,929 --> 03:46:00,598 THE TOOLS THAT WERE DEVELOPED, 6511 03:46:00,598 --> 03:46:01,298 VERY RIGOROUS AND WILL BE 6512 03:46:01,298 --> 03:46:03,501 APPLICABLE TO THE SECOND PHASE. 6513 03:46:03,501 --> 03:46:04,802 DR. HODES, YOU PRESENTED VERY 6514 03:46:04,802 --> 03:46:06,237 STRONG JUSTIFICATION OF WHY THIS 6515 03:46:06,237 --> 03:46:08,539 CONTINUES TO MEET THE CRITERIA 6516 03:46:08,539 --> 03:46:09,740 FOR COMMON FUND PROGRAMS SO I 6517 03:46:09,740 --> 03:46:11,575 WOULD SUPPORT THE EXTENSION INTO 6518 03:46:11,575 --> 03:46:12,877 PHASE TWO OF THIS PROGRAM FOR 6519 03:46:12,877 --> 03:46:13,310 ANOTHER FIVE YEARS. 6520 03:46:13,310 --> 03:46:14,879 THANK YOU. 6521 03:46:14,879 --> 03:46:17,081 >> THANK YOU FOR THE QUESTIONS 6522 03:46:17,081 --> 03:46:18,315 AND THE CHANCE TO DISCUSS IT 6523 03:46:18,315 --> 03:46:25,556 WITH YOU. 6524 03:46:25,556 --> 03:46:26,624 >> THANK YOU. 6525 03:46:26,624 --> 03:46:28,259 DR. MANLY, WOULD YOU LIKE TO ADD 6526 03:46:28,259 --> 03:46:28,759 ANY COMMENTS? 6527 03:46:28,759 --> 03:46:30,194 >> JAN! 6528 03:46:30,194 --> 03:46:35,366 >> HI, HI, RICHARD. 6529 03:46:35,366 --> 03:46:37,034 IT'S SO GOOD TO SEE YOU. 6530 03:46:37,034 --> 03:46:38,536 I'M GOING TO TURN MY CAMERA OFF 6531 03:46:38,536 --> 03:46:40,437 BECAUSE I'VE BEEN HAVING SOME 6532 03:46:40,437 --> 03:46:43,440 CONNECTION IRK E ISSUES TODAY AM 6533 03:46:43,440 --> 03:46:44,308 GOING TO ASK SOME QUESTIONS THAT 6534 03:46:44,308 --> 03:46:45,910 YOU MAY FIND A LITTLE IRRITATE, 6535 03:46:45,910 --> 03:46:50,815 I'M AFRAID. 6536 03:46:50,815 --> 03:46:51,482 THEY'RE VERY GENERAL. 6537 03:46:51,482 --> 03:46:55,186 I AM IN FAVOR OF THIS SCIENCE, I 6538 03:46:55,186 --> 03:46:59,523 AGREE WITH DR. LLOYD THAT IT IS 6539 03:46:59,523 --> 03:47:03,460 RIGOROUS, THAT YOU'VE MADE -- BY 6540 03:47:03,460 --> 03:47:04,228 EVALUATING SOME OF THE 6541 03:47:04,228 --> 03:47:06,530 CHALLENGES THAT CAME UP IN STAGE 6542 03:47:06,530 --> 03:47:09,233 ONE, YOU'VE PLANNED YOUR SECOND 6543 03:47:09,233 --> 03:47:11,202 STAGE, I THINK, THOUGHTFULLY AND 6544 03:47:11,202 --> 03:47:13,404 APPROPRIATELY. 6545 03:47:13,404 --> 03:47:15,706 BUT I THINK I NEED MORE 6546 03:47:15,706 --> 03:47:16,974 INFORMATION ABOUT THE CRITERIA 6547 03:47:16,974 --> 03:47:20,144 FOR CONTINUING ANY COMMON FUND 6548 03:47:20,144 --> 03:47:21,345 PROGRAM BEYOND THE FIRST FIVE 6549 03:47:21,345 --> 03:47:27,251 YEARS. 6550 03:47:27,251 --> 03:47:31,922 SO ONE EXAMPLE OF MY QUESTION 6551 03:47:31,922 --> 03:47:35,092 IS, WHAT'S THE RATIONAL FOR 6552 03:47:35,092 --> 03:47:36,760 KEEPING SENNET WITHIN THE COMMON 6553 03:47:36,760 --> 03:47:36,961 FUND. 6554 03:47:36,961 --> 03:47:38,362 IN OTHER WORDS, HOW IS THIS 6555 03:47:38,362 --> 03:47:44,034 BETTER THAN IC-DRIVEN PROGRAMS? 6556 03:47:44,034 --> 03:47:46,003 HOW HAS THE COST-EFFECTIVENESS 6557 03:47:46,003 --> 03:47:54,111 OF PHASE ONE BR BEEN EVALUATED N 6558 03:47:54,111 --> 03:47:56,146 THE CONTEXT OF ITS DOWNSTREAM 6559 03:47:56,146 --> 03:47:56,380 IMPACT? 6560 03:47:56,380 --> 03:47:57,381 YOU SPENT SOME TIME DISCUSSING 6561 03:47:57,381 --> 03:47:59,683 WITH US THE CATALYTIC AND 6562 03:47:59,683 --> 03:48:01,452 TRANSFORMATIVE CRITERIA OF 6563 03:48:01,452 --> 03:48:04,788 COMMON FUND PROGRAMS. 6564 03:48:04,788 --> 03:48:10,160 MY QUESTION TO YOU IS, HOW WILL 6565 03:48:10,160 --> 03:48:12,897 THE ACCELERATION OF SENESCENCE 6566 03:48:12,897 --> 03:48:14,832 RESEARCH BE MEASURED BY THIS 6567 03:48:14,832 --> 03:48:15,065 PROGRAM? 6568 03:48:15,065 --> 03:48:18,469 YOU IN YOUR SLIDES INCLUDED 6569 03:48:18,469 --> 03:48:19,470 SENNET GRANTS IN THAT, BUT IS 6570 03:48:19,470 --> 03:48:23,274 THAT REALLY HOW WE SHOULD BE 6571 03:48:23,274 --> 03:48:24,909 MEASURING HOW A COMMON FUND 6572 03:48:24,909 --> 03:48:26,677 PROGRAM ACCELERATES SCIENCE IN A 6573 03:48:26,677 --> 03:48:28,512 PARTICULAR AREA? 6574 03:48:28,512 --> 03:48:30,514 IS THAT -- IT FUNDS GRANTS 6575 03:48:30,514 --> 03:48:34,652 WITHIN ITS PROGRAM? 6576 03:48:34,652 --> 03:48:35,853 THEN MY FINAL QUESTION IS, HOW 6577 03:48:35,853 --> 03:48:38,923 HAS THE SENNET PROGRAM BENEFITED 6578 03:48:38,923 --> 03:48:41,325 VULNERABLE POPULATIONS, PATIENT 6579 03:48:41,325 --> 03:48:45,462 GROUPS, AND HOW HAS IT -- HAS IT 6580 03:48:45,462 --> 03:48:47,865 BEEN TAKEN UP BY A 6581 03:48:47,865 --> 03:48:49,266 REPRESENTATIVE RANGE OF 6582 03:48:49,266 --> 03:48:49,600 INSTITUTIONS? 6583 03:48:49,600 --> 03:48:50,734 AND I'LL PUT THESE QUESTIONS IN 6584 03:48:50,734 --> 03:48:53,637 THE CHAT BECAUSE I KNOW IT'S 6585 03:48:53,637 --> 03:48:53,804 ALO. 6586 03:48:53,804 --> 03:48:56,140 >> SORRY. 6587 03:48:56,140 --> 03:48:57,975 I'LL TRY TO GET THROUGH THEM, 6588 03:48:57,975 --> 03:48:58,943 JEN. 6589 03:48:58,943 --> 03:48:59,677 THE FIRST WAS AN IMPORTANT 6590 03:48:59,677 --> 03:49:03,781 GENERAL QUESTION, WHEN SHOULD 6591 03:49:03,781 --> 03:49:05,816 COMMON FUND PROGRAM LIKE SENNET 6592 03:49:05,816 --> 03:49:07,217 BE EXTENDED, HOW DO WE KNOW IT 6593 03:49:07,217 --> 03:49:09,086 SHOULD BE EXTENDED RATHER THAN 6594 03:49:09,086 --> 03:49:10,721 HAVING COMPLETED ITS GOALS. 6595 03:49:10,721 --> 03:49:11,622 IT'S A CHALLENGING QUESTION AND 6596 03:49:11,622 --> 03:49:12,823 IT SHOULDN'T BE TAKEN LIGHTLY. 6597 03:49:12,823 --> 03:49:15,192 I WOULD SAY IN THE CASE OF 6598 03:49:15,192 --> 03:49:15,993 SENNET AS I'VE ILLUSTRATED, 6599 03:49:15,993 --> 03:49:18,495 WE'VE LEARNED A GREAT DEAL ABOUT 6600 03:49:18,495 --> 03:49:20,898 THE HETEROGENEITY OF SENESCENT 6601 03:49:20,898 --> 03:49:22,199 WE DIDN'T KNOW BEFORE, FROM 6602 03:49:22,199 --> 03:49:23,400 TISSUE TO TISSUE AND IN 6603 03:49:23,400 --> 03:49:25,736 DIFFERENT SETTINGS, WE HAVE THE 6604 03:49:25,736 --> 03:49:27,104 DATASETS THAT REX TENSIVE BUT 6605 03:49:27,104 --> 03:49:29,840 NOT COMPLETE, AND IF THE GOAL IS 6606 03:49:29,840 --> 03:49:32,643 TO PROVIDE ATLASES WHICH WERE 6607 03:49:32,643 --> 03:49:34,178 EXPRESSED EX-! 6608 03:49:34,178 --> 03:49:35,279 PUBLICITILY AS A GOAL, THAT THEN 6609 03:49:35,279 --> 03:49:36,613 SHOULD BE EASILY ACCESSIBLE AND 6610 03:49:36,613 --> 03:49:38,549 USABLE BY THE RESEARCH 6611 03:49:38,549 --> 03:49:39,883 COMMUNITY, THAT'S THE STATE AT 6612 03:49:39,883 --> 03:49:41,752 WHICH I THINK THE COMMON FUND 6613 03:49:41,752 --> 03:49:42,619 INITIATIVE SUCH AS THIS WILL 6614 03:49:42,619 --> 03:49:44,121 HAVE ACCOMPLISHED ITS MISSION, I 6615 03:49:44,121 --> 03:49:45,789 THINK WITHOUT THE SECOND STAGE, 6616 03:49:45,789 --> 03:49:47,891 WE WOULD HAVE BEEN SUCCESSFUL IN 6617 03:49:47,891 --> 03:49:49,259 PROVOKING MORE RESEARCH BUT NOT 6618 03:49:49,259 --> 03:49:50,394 NEARLY AS EXTENSIVELY AS WOULD 6619 03:49:50,394 --> 03:49:52,029 BE THE CASE AFTER A SECOND 6620 03:49:52,029 --> 03:49:55,966 PHASE, COMPLETED ATLASES, WELL 6621 03:49:55,966 --> 03:49:56,734 ANNOTATED AND ACCESSIBLE TO THE 6622 03:49:56,734 --> 03:49:58,135 RESEARCH COMMUNITY. 6623 03:49:58,135 --> 03:49:59,670 RELATED TO YOUR SECOND POINT, I 6624 03:49:59,670 --> 03:50:01,105 THINK WAS ABOUT HOW DO WE 6625 03:50:01,105 --> 03:50:02,506 MEASURE SUCCESS, AND CLEARLY 6626 03:50:02,506 --> 03:50:06,343 JUST THE FACT THAT WE HAVE 6627 03:50:06,343 --> 03:50:08,879 FUNDED PUBLICATIONS BY A COMMON 6628 03:50:08,879 --> 03:50:12,783 FUND INITIATIVE ITSELF ARE NOT 6629 03:50:12,783 --> 03:50:14,518 SUFFICIENT, ONE, RELATIVELY 6630 03:50:14,518 --> 03:50:15,519 PROXIMATE OUT COME WOULD BE WHEN 6631 03:50:15,519 --> 03:50:18,288 THE FIELD TAKES OFF AND NOW 6632 03:50:18,288 --> 03:50:19,723 RESEARCH IN THE FIELD OF A 6633 03:50:19,723 --> 03:50:21,392 COMMON FUND INITIATIVE LIKE 6634 03:50:21,392 --> 03:50:22,893 SENNET IS BEING SUPPORTED BY 6635 03:50:22,893 --> 03:50:26,497 GRANTS OUTSIDE OF SENNET ITSELF, 6636 03:50:26,497 --> 03:50:28,032 I WOULD EXPECT TO SEE IN THE 6637 03:50:28,032 --> 03:50:29,833 NEXT YEARS A GROWING AMOUNT OF 6638 03:50:29,833 --> 03:50:33,837 THIS AND EVEN MORE ACCELERATION 6639 03:50:33,837 --> 03:50:36,673 WE APPROACH THE END OF WHAT I 6640 03:50:36,673 --> 03:50:38,742 HOPE WILL BE THE SECOND PHASE, 6641 03:50:38,742 --> 03:50:40,377 ALLOWING INVESTIGATORS TO ENTER, 6642 03:50:40,377 --> 03:50:41,979 SO A MEASURE OF SUCCESS WE'VE 6643 03:50:41,979 --> 03:50:44,782 USED, JEN, I THINK YOU'VE SEEN 6644 03:50:44,782 --> 03:50:46,750 IN OUR OTHER INITIATIVES, WE GET 6645 03:50:46,750 --> 03:50:48,085 TO THE STAGE WHERE INVESTIGATORS 6646 03:50:48,085 --> 03:50:49,253 WERE NEVER EVEN FUNDED BY THE 6647 03:50:49,253 --> 03:50:51,321 INITIATIVE ITSELF, LIKE SENNET, 6648 03:50:51,321 --> 03:50:52,890 I THINK THAT'S A CRITERION THAT 6649 03:50:52,890 --> 03:50:55,292 WE'VE CATALYZED THE FIELD AND WE 6650 03:50:55,292 --> 03:50:57,528 CAN STEP BACK AND BE GRATIFIED 6651 03:50:57,528 --> 03:50:58,462 IN THAT. 6652 03:50:58,462 --> 03:50:59,263 YOUR THIRD AND FINAL QUESTION, 6653 03:50:59,263 --> 03:51:00,864 HIGH IN MIND FOR ALL WE DO, HOW 6654 03:51:00,864 --> 03:51:04,034 THIS PE BENEFITS PEOPLE, 6655 03:51:04,034 --> 03:51:05,335 POPULATIONS, THE FULL SCOPE OF 6656 03:51:05,335 --> 03:51:06,670 THE AMERICAN GLOBAL POPULATIONS. 6657 03:51:06,670 --> 03:51:09,540 THE FACT THAT IN THE 6658 03:51:09,540 --> 03:51:13,477 PRE-CLINICAL ANIMAL MODELS, THE 6659 03:51:13,477 --> 03:51:17,514 REVERSAL OF SENESCENCE AND 6660 03:51:17,514 --> 03:51:18,649 ELIMINATION OF SENESCENT CELLS 6661 03:51:18,649 --> 03:51:20,818 HAS SHOWN PROMISING IMPACTS ON 6662 03:51:20,818 --> 03:51:23,454 VARIETIES OF AGE-RELATED 6663 03:51:23,454 --> 03:51:25,556 PATHOLOGIES, GIVES US STRONG 6664 03:51:25,556 --> 03:51:26,657 CONFIDENCE, THOUGH WE NEVER KNOW 6665 03:51:26,657 --> 03:51:29,393 UNTIL THE END PRODUCT, THAT BY 6666 03:51:29,393 --> 03:51:30,027 INTERVENING ON SENESCENT CELLS, 6667 03:51:30,027 --> 03:51:31,929 WE'LL BE IMPACTING MANY ASPECTS 6668 03:51:31,929 --> 03:51:34,465 OF AGING, THE PRECURSORS TO MANY 6669 03:51:34,465 --> 03:51:36,867 CONDITIONS AND DISEASES, WHICH 6670 03:51:36,867 --> 03:51:38,635 AFFECT VERY DIVERSE POPULATIONS. 6671 03:51:38,635 --> 03:51:40,270 SO THERE'S NO QUESTION THE BASIC 6672 03:51:40,270 --> 03:51:41,572 SCIENCE SEEMS RELEVANT TO THOSE 6673 03:51:41,572 --> 03:51:43,307 DISEASE AND CONDITIONS WHICH 6674 03:51:43,307 --> 03:51:46,610 IMPACT DIVERSE POPULATIONS. 6675 03:51:46,610 --> 03:51:50,314 THE FINAL MOUNTAIN TO ACHIEVE 6676 03:51:50,314 --> 03:51:52,049 AND TO CLIMB, OF COURSE, IS TO 6677 03:51:52,049 --> 03:51:53,717 TRANSLATE INTO INTERVENTIONS 6678 03:51:53,717 --> 03:51:55,886 WHICH THEN CAN AND WILL BE 6679 03:51:55,886 --> 03:51:57,754 APPLIED IN THOSE DIVERSE 6680 03:51:57,754 --> 03:51:58,856 POPULATIONS THAT WE ARE TALKING 6681 03:51:58,856 --> 03:51:59,289 ABOUT. 6682 03:51:59,289 --> 03:52:01,692 UNTIL THAT, WE DON'T HAVE THE 6683 03:52:01,692 --> 03:52:03,093 FINE SUCCESS THAT I THINK WE 6684 03:52:03,093 --> 03:52:04,862 ASPIRE AND FEEL IS A PROMISE YET 6685 03:52:04,862 --> 03:52:06,597 TO BE ACHIEVED AND DEMONSTRATED 6686 03:52:06,597 --> 03:52:07,798 BY THE INITIATIVE. 6687 03:52:07,798 --> 03:52:09,867 SO I THINK THOSE ARE YOUR THEE 6688 03:52:09,867 --> 03:52:11,168 POINT. 6689 03:52:11,168 --> 03:52:14,605 S. 6690 03:52:14,605 --> 03:52:16,974 >> JUST ONE MORE ADDITION TO THE 6691 03:52:16,974 --> 03:52:23,113 LAST ONE, WHICH IS HAVE THE 6692 03:52:23,113 --> 03:52:26,517 SENNET GRANTS BEEN AWARDED TO 6693 03:52:26,517 --> 03:52:28,152 REPRESENTATIVE SET OF 6694 03:52:28,152 --> 03:52:29,887 INSTITUTIONS THAT ARE ELIGIBLE 6695 03:52:29,887 --> 03:52:33,757 FOR NIH GRANTS? 6696 03:52:33,757 --> 03:52:39,963 >> THAT'S A GOOD QUESTION, AND 6697 03:52:39,963 --> 03:52:40,697 REPRESENTATIVES IS A CHALLENGING 6698 03:52:40,697 --> 03:52:41,798 PART OF THE QUESTION, I DON'T 6699 03:52:41,798 --> 03:52:42,132 KNOW. 6700 03:52:42,132 --> 03:52:43,667 MULTIPLE AWARDS TO MULTIPLE 6701 03:52:43,667 --> 03:52:49,840 INSTITUTIONS THAT ARE GENERALLY 6702 03:52:49,840 --> 03:52:52,743 RESEARCH ONE INSTITUTIONS, BUT 6703 03:52:52,743 --> 03:52:53,877 FAIR TO TAKE A LOOK. 6704 03:52:53,877 --> 03:52:55,512 AND YOU KNOW, IF THERE'S A 6705 03:52:55,512 --> 03:52:57,447 SECOND PHASE COMING UP AND WE'RE 6706 03:52:57,447 --> 03:53:02,119 LOOKING AGAIN AT THE OUTCOMES OF 6707 03:53:02,119 --> 03:53:03,120 A SECOND ADVERTISEMENT, I SHOULD 6708 03:53:03,120 --> 03:53:04,688 SAY THAT THE PLAN IS FOR STAGE 6709 03:53:04,688 --> 03:53:08,358 TWO, NOT TO LIMIT THAT TO JUST 6710 03:53:08,358 --> 03:53:12,930 THOSE SUCCESSFUL SITES IN THE 6711 03:53:12,930 --> 03:53:14,464 FIRST PHASE BUT VERY EXPLICITLY 6712 03:53:14,464 --> 03:53:16,466 TO HOPE THAT MORE AND A BROADER 6713 03:53:16,466 --> 03:53:18,669 SPECTRUM OF INSTITUTIONS WILL BE 6714 03:53:18,669 --> 03:53:22,472 CAPABLE OF GENERATING PROPOSALS, 6715 03:53:22,472 --> 03:53:24,007 AND I WOULD ALSO POINT OUT I 6716 03:53:24,007 --> 03:53:25,108 THINK IT'S BEEN A RULE RATHER 6717 03:53:25,108 --> 03:53:26,643 THAN AN EXCEPTION, THAT THESE 6718 03:53:26,643 --> 03:53:29,947 PROPOSALS HAVE COME FROM COP 6719 03:53:29,947 --> 03:53:31,248 CONSORTIA OF INSTITUTIONS, EACH 6720 03:53:31,248 --> 03:53:32,883 OF THE INDIVIDUAL AWARDS ITSELF 6721 03:53:32,883 --> 03:53:35,018 IS FROM A CONSORTIUM, SOMETHING 6722 03:53:35,018 --> 03:53:36,753 TO BE RECOGNIZED, AND ANOTHER 6723 03:53:36,753 --> 03:53:38,822 ASPECT OF THE SENNET ACTIVITIES 6724 03:53:38,822 --> 03:53:40,290 THAT WAS NOT STRESSED IN THE 6725 03:53:40,290 --> 03:53:42,092 SCIENCE ASPECT WAS I THINK A 6726 03:53:42,092 --> 03:53:44,995 VERY SUCCESSFUL MODEL OF 6727 03:53:44,995 --> 03:53:47,197 DEVELOPING A PROGRAM FOR NEW, 6728 03:53:47,197 --> 03:53:50,968 YOUNG AND EMERGING INVESTIGATORS 6729 03:53:50,968 --> 03:53:52,502 AND SOME THROUGH TRAINING TO 6730 03:53:52,502 --> 03:53:54,238 EXPERIENCE RESEARCH IN THE 6731 03:53:54,238 --> 03:53:58,075 PROGRAMS VERY EXPLICITLY, JEN, 6732 03:53:58,075 --> 03:53:59,610 INTENDING THOSE TO BE A NEXT 6733 03:53:59,610 --> 03:54:00,277 INCLUSIVE GENERATION OF PEOPLE 6734 03:54:00,277 --> 03:54:01,678 WHO MAY NOT EVEN HAVE BEEN IN 6735 03:54:01,678 --> 03:54:03,580 MANY OF THESE CASES AT THE 6736 03:54:03,580 --> 03:54:04,615 INSTITUTIONS THAT GOT THE FIRST 6737 03:54:04,615 --> 03:54:04,915 AWARD. 6738 03:54:04,915 --> 03:54:07,551 SO I THINK THERE'S BEEN A VERY 6739 03:54:07,551 --> 03:54:09,853 CONSCIOUS EFFORT TO BROADEN THE 6740 03:54:09,853 --> 03:54:10,954 RESEARCH COMMUNITY THAT IS 6741 03:54:10,954 --> 03:54:13,290 LIKELY TO BE INVOLVED IN THE 6742 03:54:13,290 --> 03:54:17,094 SECOND PHASE OF RESEARCH, AND 6743 03:54:17,094 --> 03:54:18,295 BEYOND, AND CREDITS TO EVEN 6744 03:54:18,295 --> 03:54:19,496 BEYOND THE RESEARCH 6745 03:54:19,496 --> 03:54:20,264 ACCOMPLISHMENT ITSELF TO THE 6746 03:54:20,264 --> 03:54:23,900 WORK OF THIS CONSORTIUM. 6747 03:54:23,900 --> 03:54:26,737 >> RICHARD, I'LL JUST ADD ON 6748 03:54:26,737 --> 03:54:28,372 THAT LAST POINT, THIS IS 6749 03:54:28,372 --> 03:54:30,607 CAROLYN, TO SAY THAT WE ARE ALSO 6750 03:54:30,607 --> 03:54:33,243 DOING THAT NOT JUST WITHIN 6751 03:54:33,243 --> 03:54:36,847 SENNET BUT SENNET LTS ALSO 6752 03:54:36,847 --> 03:54:38,181 PARTICIPATES IN OUR LARGER 6753 03:54:38,181 --> 03:54:39,816 HECOSIS TEM AND WE HAVE SOME 6754 03:54:39,816 --> 03:54:42,119 ACTIVITIES WITHIN THAT DATA 6755 03:54:42,119 --> 03:54:43,553 ECOSYSTEM INCLUDING 6756 03:54:43,553 --> 03:54:44,588 R03 OPPORTUNITIES FOR PEOPLE TO 6757 03:54:44,588 --> 03:54:46,390 COME IN AND USE THE EXISTING 6758 03:54:46,390 --> 03:54:49,226 DATASETS FROM SENNET OR OTHER 6759 03:54:49,226 --> 03:54:50,560 PROJECTS EITHER INDIVIDUALLY OR 6760 03:54:50,560 --> 03:54:52,629 TOGETHER AS WELL AS TRAINING AND 6761 03:54:52,629 --> 03:54:54,831 EDUCATION, OUTREACH ACTIVITIES 6762 03:54:54,831 --> 03:54:56,133 WITHIN THAT PROGRAM THAT ALSO 6763 03:54:56,133 --> 03:54:58,335 HELP BROADEN THE SCOPE NOT JUST 6764 03:54:58,335 --> 03:55:01,738 OF WHO'S GETTING SOME COMMON 6765 03:55:01,738 --> 03:55:03,707 FUND FUNDING TO WORK WITH SENNET 6766 03:55:03,707 --> 03:55:05,042 AND DATA BUT ALSO GETTING THAT 6767 03:55:05,042 --> 03:55:06,143 EXPOSURE AND THE ABILITY TO SORT 6768 03:55:06,143 --> 03:55:07,344 OF USE THAT COMMON FUND 6769 03:55:07,344 --> 03:55:08,245 RESOURCES. 6770 03:55:08,245 --> 03:55:09,146 > 6771 03:55:09,146 --> 03:55:10,447 >> THANKS, CAROLYN. 6772 03:55:10,447 --> 03:55:13,717 >> AND I MIGHT ASK, CAROLYN, IF 6773 03:55:13,717 --> 03:55:15,185 YOU JUST TO ENSURE THAT WE HAVE 6774 03:55:15,185 --> 03:55:18,155 ADDRESSED ALL OF DR. MANLY'S 6775 03:55:18,155 --> 03:55:19,256 QUESTIONS, IF YOU MAYBE WANT TO 6776 03:55:19,256 --> 03:55:21,458 EXPAND A LITTLE BIT ON SORT OF 6777 03:55:21,458 --> 03:55:24,428 THE RATIONALE FOR KEEPING SENNET 6778 03:55:24,428 --> 03:55:25,295 WITHIN COMMON FUND AND HOW THIS 6779 03:55:25,295 --> 03:55:27,597 TYPE OF A TRANSFORMATIVE 6780 03:55:27,597 --> 03:55:28,231 CROSS-CUTTING RESEARCH PROGRAM 6781 03:55:28,231 --> 03:55:31,768 IS REALLY BEST SUPPORTED BY A 6782 03:55:31,768 --> 03:55:34,705 COMMON FUND THAT ALLOWS -- THE 6783 03:55:34,705 --> 03:55:35,806 COMMON FUND AS A PROGRAM 6784 03:55:35,806 --> 03:55:37,774 ALLOWING US TO WORK 6785 03:55:37,774 --> 03:55:38,775 COOPERATIVELY ACROSS MANY 6786 03:55:38,775 --> 03:55:40,210 DIFFERENT ICs RATHER THAN 6787 03:55:40,210 --> 03:55:42,379 HAVING THAT BE DRIVEN WITHIN AN 6788 03:55:42,379 --> 03:55:43,914 INDIVIDUAL OR EVEN WITH A COUPLE 6789 03:55:43,914 --> 03:55:45,148 OF ICs. 6790 03:55:45,148 --> 03:55:46,783 FOR ME FROM A BIOLOGICAL 6791 03:55:46,783 --> 03:55:47,984 PERSPECTIVE, CELLULAR SENESCENCE 6792 03:55:47,984 --> 03:55:49,186 AFFECTS SO MANY DIFFERENT END 6793 03:55:49,186 --> 03:55:51,021 POINTS AND SO MANY DIFFERENT 6794 03:55:51,021 --> 03:55:52,522 PIECE OF BIOMEDICAL RESEARCH 6795 03:55:52,522 --> 03:55:57,394 THAT I THINK THAT THAT PROVIDES 6796 03:55:57,394 --> 03:55:58,495 SOME STRONG SUPPORT TO IT BUT 6797 03:55:58,495 --> 03:55:59,830 I'D LIKE TO ASK IF THERE'S 6798 03:55:59,830 --> 03:56:00,831 ANYTHING ELSE YOU'D LIKE TO ADD 6799 03:56:00,831 --> 03:56:01,998 ON THAT PARTICULAR POINT. 6800 03:56:01,998 --> 03:56:03,100 >> I THINK I'D VERY MUCH BUILD 6801 03:56:03,100 --> 03:56:05,402 ON WHAT YOU SAID AND ALSO 6802 03:56:05,402 --> 03:56:07,704 DR. HODES IN THINKING ABOUT THIS 6803 03:56:07,704 --> 03:56:09,339 PROGRAM, YOU KNOW, IS THE 6804 03:56:09,339 --> 03:56:11,208 WORKING GROUP COMES FROM THE 6805 03:56:11,208 --> 03:56:12,442 DIFFERENT ICs AND IF IT 6806 03:56:12,442 --> 03:56:13,744 TRANSITION AND WE SAID OH, THIS 6807 03:56:13,744 --> 03:56:16,480 IS MOSTLY OF INTEREST TO AGE, 6808 03:56:16,480 --> 03:56:18,348 I'M NOT INSULTING MY NIA 6809 03:56:18,348 --> 03:56:19,449 COLLEAGUES BUT I'M SAYING WE'D 6810 03:56:19,449 --> 03:56:20,751 THEN LOSE THE PERSPECTIVE THAT 6811 03:56:20,751 --> 03:56:22,819 HAVING THIS AS A COMMON FUND 6812 03:56:22,819 --> 03:56:25,021 PROGRAM WITH THAT TRANSNIH 6813 03:56:25,021 --> 03:56:28,625 WORKING GROUP AND THAT NIH-WIDE 6814 03:56:28,625 --> 03:56:31,695 COLLABORATION BRINGING IN THE 6815 03:56:31,695 --> 03:56:32,596 EXPERTISE ACROSS THE DIFFERENT 6816 03:56:32,596 --> 03:56:33,363 AREAS AND THE REAL STATION OF 6817 03:56:33,363 --> 03:56:35,198 HOW TO THINK, PARTICULARLY IN 6818 03:56:35,198 --> 03:56:38,168 PHASE TWO WHERE THERE'S THIS 6819 03:56:38,168 --> 03:56:41,405 DISEASE FOCUS, HOW TO INTEGRATE 6820 03:56:41,405 --> 03:56:43,573 IT IN WITH THE SUBJECT MATTER 6821 03:56:43,573 --> 03:56:45,442 EXPERTS AND EXPERTISE WITHIN 6822 03:56:45,442 --> 03:56:46,209 AUTOIMMUNE CROSS THE NIH. 6823 03:56:46,209 --> 03:56:47,344 SO IT IS ONE OF THE THINGS THAT 6824 03:56:47,344 --> 03:56:49,946 WE ASK AND DR. HODES LAID OUT, 6825 03:56:49,946 --> 03:56:52,482 THIS TIEING IN TO THOSE FIVE 6826 03:56:52,482 --> 03:56:54,384 CRITERIA AND THE SYNERGISM AND 6827 03:56:54,384 --> 03:56:56,653 THE SORT OF APPLICABILITY ACROSS 6828 03:56:56,653 --> 03:56:58,255 NIH IS A CRITICAL THING THAT WE 6829 03:56:58,255 --> 03:57:00,524 ASK IN CONSIDERING THE 6830 03:57:00,524 --> 03:57:02,626 CONTINUATION OF A PROGRAM WITHIN 6831 03:57:02,626 --> 03:57:04,461 COMMON FUND AS OPPOSED TO MAKING 6832 03:57:04,461 --> 03:57:07,197 IT SOMETHING THAT WOULD BE 6833 03:57:07,197 --> 03:57:08,799 TRANSITIONED INTO AN IC. 6834 03:57:08,799 --> 03:57:10,467 BECAUSE WE HAVE COMMON FUND 6835 03:57:10,467 --> 03:57:11,334 PROGRAMS THAT HAVE DONE BOTH. 6836 03:57:11,334 --> 03:57:13,336 IN THIS CASE, I THINK IT'S 6837 03:57:13,336 --> 03:57:18,275 REALLY THE APPLICABILITY OF THIS 6838 03:57:18,275 --> 03:57:20,343 TO -- ACTIVITY ACROSS THE ENTIRE 6839 03:57:20,343 --> 03:57:22,746 NIH MISSION THAT MAKES IT 6840 03:57:22,746 --> 03:57:25,048 BENEFIT FROM THAT NIH-WIDE 6841 03:57:25,048 --> 03:57:26,783 COORDINATION AND PERSPECTIVE 6842 03:57:26,783 --> 03:57:27,984 THAT COMES THROUGH COMMON FUND 6843 03:57:27,984 --> 03:57:36,092 PROGRAMS. 6844 03:57:36,092 --> 03:57:38,195 >> THANK YOU, CAROLYN. 6845 03:57:38,195 --> 03:57:39,496 I'LL ASK JENNIFER IF YOUR IF HES 6846 03:57:39,496 --> 03:57:43,266 HAVE ALL BEEN A -- YOUR 6847 03:57:43,266 --> 03:57:44,034 QUESTIONS HAVE ALL BEEN 6848 03:57:44,034 --> 03:57:44,301 ADDRESSED? 6849 03:57:44,301 --> 03:57:45,101 >> YES, THEY HAVE. 6850 03:57:45,101 --> 03:57:49,940 >> FAN T FANTASTIC. 6851 03:57:49,940 --> 03:57:51,575 IF YOU HAVE QUESTIONS, PLEASE 6852 03:57:51,575 --> 03:57:52,976 RAISE YOUR HAND AND YOU'LL BE 6853 03:57:52,976 --> 03:57:54,244 RECOGNIZE AND ASKED TO UNMUTE 6854 03:57:54,244 --> 03:57:54,644 YOURSELF. 6855 03:57:54,644 --> 03:57:56,179 IF NOT, WE WILL PROCEED TO A 6856 03:57:56,179 --> 03:58:00,417 VOTE. 6857 03:58:00,417 --> 03:58:01,184 FRANZISKA, GO AHEAD. 6858 03:58:01,184 --> 03:58:04,321 >> GREAT, THANK YOU. 6859 03:58:04,321 --> 03:58:05,622 I WILL BE CALLING FOR THE VOTE 6860 03:58:05,622 --> 03:58:08,158 AND THAT WILL READ, MAY I HAVE A 6861 03:58:08,158 --> 03:58:09,826 MOTION FOR APPROVAL OF THE 6862 03:58:09,826 --> 03:58:12,529 COMMON FUND CONCEPT CLEARANCE 6863 03:58:12,529 --> 03:58:15,165 STAGE TWO ENTITLED CELLULAR 6864 03:58:15,165 --> 03:58:17,234 SENESCENCE NETWORK, SENNET 6865 03:58:17,234 --> 03:58:19,769 PROGRAM. 6866 03:58:19,769 --> 03:58:21,538 IF YOU SUPPORT THE MOTION, 6867 03:58:21,538 --> 03:58:22,506 PLEASE SAY SO MOVED. 6868 03:58:22,506 --> 03:58:23,340 I SEE THE SECOND. 6869 03:58:23,340 --> 03:58:25,375 IS THERE ANY ADDITIONAL 6870 03:58:25,375 --> 03:58:32,182 DISCUSSION AT THIS POINT? 6871 03:58:32,182 --> 03:58:32,849 I SEE ONE HAND. 6872 03:58:32,849 --> 03:58:34,284 IS THAT FROM BEFORE? 6873 03:58:34,284 --> 03:58:37,220 MONICA. 6874 03:58:37,220 --> 03:58:42,058 OH, YOU'RE MUTED. 6875 03:58:42,058 --> 03:58:45,896 >> I MEANT YEA, I DIDN'T MEAN 6876 03:58:45,896 --> 03:58:46,429 NAY. 6877 03:58:46,429 --> 03:58:46,897 SORRY. 6878 03:58:46,897 --> 03:58:50,033 >> THANK YOU. 6879 03:58:50,033 --> 03:58:51,368 SO IF THERE IS NO MORE 6880 03:58:51,368 --> 03:58:52,369 DISCUSSION, WE'LL DO THE SAME 6881 03:58:52,369 --> 03:58:52,903 PROCEDURE OVER. 6882 03:58:52,903 --> 03:58:56,406 I TURN IT OVER TO CHRIS TEAL NAR 6883 03:58:56,406 --> 03:58:57,374 THE HAND RAISING VOTE. 6884 03:58:57,374 --> 03:58:59,142 >> THANK YOU, DR. GRIEDER. 6885 03:58:59,142 --> 03:59:00,911 AS A REMINDER ONLY 6886 03:59:00,911 --> 03:59:01,378 COUNCILMEMBERS SHOULD 6887 03:59:01,378 --> 03:59:04,948 PARTICIPATE IN THIS VOTE. 6888 03:59:04,948 --> 03:59:07,684 THIS IS A VOTE ON THE MOTION FOR 6889 03:59:07,684 --> 03:59:09,185 APPROVAL OF THE PRESENTED 6890 03:59:09,185 --> 03:59:10,020 CONCEPT CLEARANCE. 6891 03:59:10,020 --> 03:59:11,388 PLEASE RAISE YOUR HAND TO VOTE 6892 03:59:11,388 --> 03:59:20,463 AYE. 6893 03:59:20,463 --> 03:59:25,268 I SEE 13 HANDS, I SEE 14 HANDS. 6894 03:59:25,268 --> 03:59:26,570 PLEASE RAISE YOUR HAND TO VOTE 6895 03:59:26,570 --> 03:59:32,175 AYE. 6896 03:59:32,175 --> 03:59:35,111 THANK YOU. 6897 03:59:35,111 --> 03:59:35,779 I SEE 14 HANDS. 6898 03:59:35,779 --> 03:59:36,980 PLEASE LOWER YOUR HANDS AND 6899 03:59:36,980 --> 03:59:40,083 WE'LL MOVE TO THE NEXT VOTE. 6900 03:59:40,083 --> 03:59:44,554 PLEASE RAISE YOUR HAND TO VOTE 6901 03:59:44,554 --> 03:59:52,529 NAY. 6902 03:59:52,529 --> 03:59:53,096 THANK YOU. 6903 03:59:53,096 --> 03:59:56,399 I SEE ONE HAND TO VOTE NAY. 6904 03:59:56,399 --> 04:00:03,540 PLEASE LOWER YOUR HANDS. 6905 04:00:03,540 --> 04:00:04,074 THROUGH. 6906 04:00:04,074 --> 04:00:05,709 PLEASE RAISE YOUR HANDS TO VOTE 6907 04:00:05,709 --> 04:00:10,513 ABSTENTION. 6908 04:00:10,513 --> 04:00:11,081 THANK YOU. 6909 04:00:11,081 --> 04:00:16,553 I SEE ONE HAND. 6910 04:00:16,553 --> 04:00:18,955 PLEASE LOWER YOUR HAND. 6911 04:00:18,955 --> 04:00:20,957 THIS CONCLUDES THE VOTE. 6912 04:00:20,957 --> 04:00:23,259 THE MOTION AS STATED HAS PASSED. 6913 04:00:23,259 --> 04:00:24,260 >> GREAT, THANK YOU, CHRISTINA. 6914 04:00:24,260 --> 04:00:27,464 BACK TO YOU, NICOLE. 6915 04:00:27,464 --> 04:00:27,998 >> GREAT. 6916 04:00:27,998 --> 04:00:30,200 THANK YOU SO MUCH, EVERYONE. 6917 04:00:30,200 --> 04:00:30,967 OKAY. 6918 04:00:30,967 --> 04:00:34,004 MOVE SOMETHING TO THE LAST CONCF 6919 04:00:34,004 --> 04:00:34,471 THE MEETING. 6920 04:00:34,471 --> 04:00:36,940 THIS IS ALSO FROM THE OFFICE OF 6921 04:00:36,940 --> 04:00:39,342 STRATEGIC COORDINATION AND 6922 04:00:39,342 --> 04:00:41,978 PRESENTED BY MIKE CHIANG, THE 6923 04:00:41,978 --> 04:00:44,047 NEI, THE NATIONAL EYE INSTITUTE 6924 04:00:44,047 --> 04:00:45,448 DIRECTOR, AND BRUCE TROMBERG, 6925 04:00:45,448 --> 04:00:49,352 DIRECTOR OF THE NA NATIONAL 6926 04:00:49,352 --> 04:00:50,720 INSTITUTE OF BIOMEDICAL IMAGING 6927 04:00:50,720 --> 04:00:51,488 AND BIOENGINEERING. 6928 04:00:51,488 --> 04:00:53,757 SO THE PRESENTATION FOR THIS NEW 6929 04:00:53,757 --> 04:00:54,758 CONCEPT, PUTTING MYSELF OUT ON A 6930 04:00:54,758 --> 04:00:56,159 LIMB HERE, I'M PRETTY SURE THIS 6931 04:00:56,159 --> 04:00:59,162 IS RIGHT, PRECISION MEDICINE 6932 04:00:59,162 --> 04:01:01,097 WITH AI, INTEGRATING IMAGING 6933 04:01:01,097 --> 04:01:02,732 WITH MULTIMODAL DATA, SO THE 6934 04:01:02,732 --> 04:01:05,402 PRIMED AI PROGRAM, WILL BE 6935 04:01:05,402 --> 04:01:06,536 FOLLOWED BY COMMENTS FROM THE 6936 04:01:06,536 --> 04:01:08,905 TWO ASSIGNED COUNCILMEMBER 6937 04:01:08,905 --> 04:01:09,839 DISCUSSANTS, DR. KEVIN JOHNSON 6938 04:01:09,839 --> 04:01:12,742 AND DR. LINDA CHANG. 6939 04:01:12,742 --> 04:01:26,429 SO MICHAEL, BRUCE, OVER TO YOU. 6940 04:01:26,429 --> 04:01:28,298 >> LET'S TAKE A FIVE-MINUTE 6941 04:01:28,298 --> 04:01:30,100 BREAK AND WE WILL RECONVENE AT 6942 04:01:30,100 --> 04:01:31,010 3:33. 6943 04:01:32,180 --> 04:01:34,148 >> THANK YOU, EVERYONE, FOR 6944 04:01:34,148 --> 04:01:35,450 ADHERING TO THE FIVE-MINUTE 6945 04:01:35,450 --> 04:01:37,218 RESTRICTION FOR OUR BREAK, AND 6946 04:01:37,218 --> 04:01:40,054 SO NOW WE WILL JUMP IN TO OUR 6947 04:01:40,054 --> 04:01:43,157 LAST CONCEPT PRESENTATION, SO 6948 04:01:43,157 --> 04:01:44,025 MICHAEL, BRUCE, I'M GOING TO 6949 04:01:44,025 --> 04:01:50,064 TURN IT OVER TO YOU. 6950 04:01:50,064 --> 04:01:50,898 >> THANK YOU. 6951 04:01:50,898 --> 04:01:51,633 THANKS TO ALL OF YOU FOR 6952 04:01:51,633 --> 04:01:52,834 STICKING WITH US THROUGH THIS 6953 04:01:52,834 --> 04:01:53,801 PRESENTATION OR AT LEAST 6954 04:01:53,801 --> 04:01:55,103 STARTING THE PRESENTATION. 6955 04:01:55,103 --> 04:01:57,405 SO I'M THE DIRECTOR OF NIBIB, 6956 04:01:57,405 --> 04:01:59,374 THE IMAGING AND ENGINEERING 6957 04:01:59,374 --> 04:02:01,909 INSTITUTE, AND MIKE, I DON'T 6958 04:02:01,909 --> 04:02:03,878 KNOW IF YOU'RE ON -- DID YOU 6959 04:02:03,878 --> 04:02:04,679 FLASH YOUR CAMERA ON? 6960 04:02:04,679 --> 04:02:06,280 >> I AM ON. 6961 04:02:06,280 --> 04:02:07,181 MICHAEL CHIANG, DIRECTOR OF 6962 04:02:07,181 --> 04:02:08,282 NATIONAL EYE INSTITUTE, EXCITED 6963 04:02:08,282 --> 04:02:09,817 TO BE HERE. 6964 04:02:09,817 --> 04:02:12,253 >> MIKE IS DIRECTOR OF THE 6965 04:02:12,253 --> 04:02:13,421 ORIGINAL IMAGING INSTITUTE, THE 6966 04:02:13,421 --> 04:02:17,592 VERY FIRST ONE, AND WE CONTINUE 6967 04:02:17,592 --> 04:02:18,493 TO SEE THAT MOVE FORWARD. 6968 04:02:18,493 --> 04:02:19,861 SO WE'LL BE PRESENTING TOGETHER. 6969 04:02:19,861 --> 04:02:23,231 THIS IS A NEW CONCEPT, AND 6970 04:02:23,231 --> 04:02:25,400 ALTHOUGH ONE THAT CERTAINLY HAS 6971 04:02:25,400 --> 04:02:26,668 A LOT OF DISCUSSION AND 6972 04:02:26,668 --> 04:02:28,069 POPULARITY IN OUR COMMUNITY MORE 6973 04:02:28,069 --> 04:02:28,736 BROADLY. 6974 04:02:28,736 --> 04:02:33,207 SO LET'S GO TO THE NEXT SLIDE. 6975 04:02:33,207 --> 04:02:36,778 SO WE'LL BE PRESENTING FOUR 6976 04:02:36,778 --> 04:02:37,412 BASIC IS UP SUBRAMANIAM GOALS. 6977 04:02:37,412 --> 04:02:42,050 SUB GOALS, WE'LLGIVE YOU AN IDEF 6978 04:02:42,050 --> 04:02:44,552 THESE AND THE ORIGIN BREAKING 6979 04:02:44,552 --> 04:02:45,653 THE STRUCTURE DOWN. 6980 04:02:45,653 --> 04:02:46,654 WE ANTICIPATE IN THE FIVE YEARS 6981 04:02:46,654 --> 04:02:49,290 FUNDING ABOUT 90 AWARDS, 6982 04:02:49,290 --> 04:02:51,793 SPANNING MULTIPLE AWARD TYPES, 6983 04:02:51,793 --> 04:02:52,994 REFLECTIVE OF THE KIND OF 6984 04:02:52,994 --> 04:02:54,295 COMMUNITY EFFORT THAT WE REALLY 6985 04:02:54,295 --> 04:02:56,397 NEED TO ENCOURAGE AND BUILD IN 6986 04:02:56,397 --> 04:02:57,899 ORDER TO HAVE A SUCCESSFUL 6987 04:02:57,899 --> 04:03:03,705 CONCEPT. 6988 04:03:03,705 --> 04:03:06,374 SO MIKE AND I ARE REPRESENTING A 6989 04:03:06,374 --> 04:03:07,909 REALLY AMAZING GROUP OF PEOPLE. 6990 04:03:07,909 --> 04:03:10,745 THIS IS ABOUT 50 DIFFERENT 6991 04:03:10,745 --> 04:03:12,914 INDIVIDUALS CONTRIBUTING TO THIS 6992 04:03:12,914 --> 04:03:14,348 ENTIRE CONCEPT. 6993 04:03:14,348 --> 04:03:23,991 VERY ENTHUSIASTICALLY CO-CHAIRS, 6994 04:03:23,991 --> 04:03:28,362 SUSAN GREGURICK, RICHARD HODES, 6995 04:03:28,362 --> 04:03:29,564 AND WALTER KOROSHETZ WHO LEADS 6996 04:03:29,564 --> 04:03:29,897 NINDS. 6997 04:03:29,897 --> 04:03:31,566 WE'VE WORKED REALLY CLOSELY WITH 6998 04:03:31,566 --> 04:03:35,837 COMMON FUND STAFF, CHRIS, 6999 04:03:35,837 --> 04:03:37,038 SAHANA, CAITLYN AND DAVID. 7000 04:03:37,038 --> 04:03:45,313 OUR MAIN PROGRAM COORDINATORS, 7001 04:03:45,313 --> 04:03:48,216 SANGEETA, MIKE AND KRIS FROM 7002 04:03:48,216 --> 04:03:48,649 NIBIB. 7003 04:03:48,649 --> 04:03:50,618 WE'VE ALSO COORDINATED OF COURSE 7004 04:03:50,618 --> 04:03:52,253 WITH GRANTS MANAGEMENT AND CSR, 7005 04:03:52,253 --> 04:03:54,355 AND OUR WORKING GROUP PROGRAM 7006 04:03:54,355 --> 04:03:55,890 DIRECTORS, THERE ARE ABOUT 35 OF 7007 04:03:55,890 --> 04:03:58,626 THEM FROM 19 DIFFERENT ICs, 7008 04:03:58,626 --> 04:04:00,261 INSTITUTES, CENTERS AND OFFICES, 7009 04:04:00,261 --> 04:04:02,797 REALLY REFLECTIVE OF THE BROAD 7010 04:04:02,797 --> 04:04:04,332 APPEAL OF THIS INITIATIVE THAT 7011 04:04:04,332 --> 04:04:06,534 REALLY CUTS ACROSS SO MANY 7012 04:04:06,534 --> 04:04:07,101 DIFFERENT INSTITUTES AND 7013 04:04:07,101 --> 04:04:12,774 PROGRAMS. 7014 04:04:12,774 --> 04:04:16,177 SO THIS IS THE IMENTAGING 7015 04:04:16,177 --> 04:04:18,579 REPRESENTATION, KIND OF THE 7016 04:04:18,579 --> 04:04:19,814 ICONOGRAPHY OF THE ENTIRE 7017 04:04:19,814 --> 04:04:21,349 CONCEPT, AND OF COURSE WE'LL GET 7018 04:04:21,349 --> 04:04:23,818 INTO DETAILS IN EVERY U ONE OF 7019 04:04:23,818 --> 04:04:24,418 THESE COMPONENTS. 7020 04:04:24,418 --> 04:04:26,287 BUT ALL OF YOU WHO ARE FAMILIAR 7021 04:04:26,287 --> 04:04:29,157 WITH MEDICAL IMAGING, RADIOLOGIC 7022 04:04:29,157 --> 04:04:30,691 IMAGING, FIRST OF ALL, THERE'S 7023 04:04:30,691 --> 04:04:32,560 BEEN ENORMOUS ACTIVITY IN THE 7024 04:04:32,560 --> 04:04:34,395 DEVELOPMENT OF DATA SCIENCE 7025 04:04:34,395 --> 04:04:35,296 APPROACHES, ARTIFICIAL 7026 04:04:35,296 --> 04:04:38,366 INTELLIGENCE BASED TECHNIQUES IN 7027 04:04:38,366 --> 04:04:39,567 RADIOLOGY, SO OF THE MORE THAN A 7028 04:04:39,567 --> 04:04:42,103 THOUSAND OR SO ALGORITHMS THAT 7029 04:04:42,103 --> 04:04:44,539 THE FDA HAS AUTHORIZED IN TERMS 7030 04:04:44,539 --> 04:04:46,274 OF SOFTWARE, MEDICAL DEVICE, 7031 04:04:46,274 --> 04:04:48,276 USING AI AND MACHINE LEARNING, 7032 04:04:48,276 --> 04:04:49,477 ABOUT 75% OF THEM ARE IN 7033 04:04:49,477 --> 04:04:53,748 RADIOLOGY. 7034 04:04:53,748 --> 04:04:54,849 PATHOLOGY ALSO PRESENTS UNIQUE 7035 04:04:54,849 --> 04:04:56,350 OPPORTUNITIES FOR UTE EUSING 7036 04:04:56,350 --> 04:04:57,952 DATA SCIENCES FOR EXTRACTING 7037 04:04:57,952 --> 04:04:59,287 DEEPER INFORMATION CONTENT, 7038 04:04:59,287 --> 04:05:01,389 CAMERA IMAGES, WE SAY CAMERA BUT 7039 04:05:01,389 --> 04:05:05,326 ANY WAY OR FORM OF RAS TORE 7040 04:05:05,326 --> 04:05:06,961 SCANNING BY SENSOR OR SINGLE 7041 04:05:06,961 --> 04:05:09,497 POINT IMAGING DETECTOR TO GET 7042 04:05:09,497 --> 04:05:13,134 OPTICAL IMAGING, ENDOSCOPY, OP 7043 04:05:13,134 --> 04:05:15,636 THALAMIC SCANNING, DERMATOLOGIC 7044 04:05:15,636 --> 04:05:17,271 SCANNING, VARIETY OF DIFFERENT 7045 04:05:17,271 --> 04:05:17,872 APPROACHES THERE. 7046 04:05:17,872 --> 04:05:20,141 ALL OF THESE METHODS HAVE 7047 04:05:20,141 --> 04:05:21,676 ENORMOUS INFORMATION CONTENT. 7048 04:05:21,676 --> 04:05:23,244 SO IF YOU LOOK AT WHAT IS 7049 04:05:23,244 --> 04:05:25,112 TYPICALLY DELIVERED IN 7050 04:05:25,112 --> 04:05:26,180 HEALTHCARE AT CLINICAL 7051 04:05:26,180 --> 04:05:28,382 IMPRESSION FROM A RADIOLOGY 7052 04:05:28,382 --> 04:05:29,851 REPORT MAY CONTAIN A FEW 7053 04:05:29,851 --> 04:05:32,887 SENTENCES OF INFORMATION, 7054 04:05:32,887 --> 04:05:34,422 KILOBITS OF INFORMATION CONTENT 7055 04:05:34,422 --> 04:05:35,523 BUT OUR RESEARCH COMMUNITIES IN 7056 04:05:35,523 --> 04:05:37,859 EACH OF THESE IMAGING SECTORS 7057 04:05:37,859 --> 04:05:40,061 HAVE REALLY BEEN PUSHING THE 7058 04:05:40,061 --> 04:05:42,897 ENVELOPE TO EXTRACT WHAT IS 7059 04:05:42,897 --> 04:05:45,399 CLOSER TO THE TRUE DATA SIZE OF 7060 04:05:45,399 --> 04:05:49,503 EACH OF THESE IMAGING 7061 04:05:49,503 --> 04:05:51,038 APPROACHES, MEGABYTES, 7062 04:05:51,038 --> 04:05:52,106 GIGABYTES, TERABYTES OF 7063 04:05:52,106 --> 04:05:53,307 INFORMATION CONTENT, THERE'S 7064 04:05:53,307 --> 04:05:54,709 ENORMOUS ACTIVITY BOTH WITH THE 7065 04:05:54,709 --> 04:05:56,611 DEVELOPMENT OF ADVANCED DATA 7066 04:05:56,611 --> 04:05:58,646 SCIENCE APPROACHES AND THE 7067 04:05:58,646 --> 04:06:01,215 COMBINATION OF THESE METHODS 7068 04:06:01,215 --> 04:06:02,383 WITH CLINICAL APPROACHES AND 7069 04:06:02,383 --> 04:06:03,918 CLINICAL INFORMATION CONTENT 7070 04:06:03,918 --> 04:06:06,721 FROM LAB TEST RESULTS, FROM 7071 04:06:06,721 --> 04:06:08,990 CLINICAL DATA, AND IMPRESSION 7072 04:06:08,990 --> 04:06:11,325 REPORTS THAT REALLY POTENTIALLY 7073 04:06:11,325 --> 04:06:12,860 CAN DRAMATICALLY INCREASE THE 7074 04:06:12,860 --> 04:06:14,862 POWER IN THE INFORMATION CONTENT 7075 04:06:14,862 --> 04:06:16,864 OF ALL OUR IMAGING STUDIES. 7076 04:06:16,864 --> 04:06:19,600 BUT IMAGING TENDS TO BE SOMEWHAT 7077 04:06:19,600 --> 04:06:20,534 SILOED. 7078 04:06:20,534 --> 04:06:22,136 CLINICIANS WHO ARE GUIDING 7079 04:06:22,136 --> 04:06:23,471 PATIENT MANAGEMENT DON'T REALLY 7080 04:06:23,471 --> 04:06:24,772 UNDERSTAND ALL THE DIFFERENT 7081 04:06:24,772 --> 04:06:28,943 TECHNOLOGIES AND APPROACHES THAT 7082 04:06:28,943 --> 04:06:30,077 ARE REALLY BEAUTIFULLY BEING 7083 04:06:30,077 --> 04:06:30,845 DEVELOPED BY THE RESEARCH 7084 04:06:30,845 --> 04:06:32,446 COMMUNITY AND COULD POTENTIALLY 7085 04:06:32,446 --> 04:06:34,815 INFORM HOW TO OPTIMIZE PRECISION 7086 04:06:34,815 --> 04:06:36,017 MEDICINE FOR PATIENTS. 7087 04:06:36,017 --> 04:06:37,718 SO THIS IS THE ESSENTIAL 7088 04:06:37,718 --> 04:06:39,620 CHALLENGE FOR US. 7089 04:06:39,620 --> 04:06:40,421 THERE'S ENORMOUS AMOUNT OF 7090 04:06:40,421 --> 04:06:43,991 RESEARCH THAT WE SUPPORT AT THE 7091 04:06:43,991 --> 04:06:45,393 NIH, AND MANY OF US HAVE BEEN 7092 04:06:45,393 --> 04:06:47,361 DEEPLY INVOLVED IN FOR SEVERAL 7093 04:06:47,361 --> 04:06:48,162 DECADES. 7094 04:06:48,162 --> 04:06:50,631 THIS SPANS FROM RADIOMICS TO 7095 04:06:50,631 --> 04:06:52,300 TECHNIQUES FOR EXTRACTING UNIQUE 7096 04:06:52,300 --> 04:06:53,734 INFORMATION CONTENT THAT 7097 04:06:53,734 --> 04:06:55,736 PREVIOUSLY WAS INVISIBLE IN 7098 04:06:55,736 --> 04:06:57,538 MEDICAL IMAGES BUT WITH NEW 7099 04:06:57,538 --> 04:06:59,707 TECHNIQUES FOR BACKGROUND 7100 04:06:59,707 --> 04:07:00,708 SUPPRESSION, ENHANCEMENT OF 7101 04:07:00,708 --> 04:07:01,943 CONTRAST TO BACKGROUND, AND 7102 04:07:01,943 --> 04:07:04,779 CORRELATING WHAT WE SEE IN AN 7103 04:07:04,779 --> 04:07:06,414 IMAGE WITH ALL OF THE LAB 7104 04:07:06,414 --> 04:07:08,249 RESULTS AND CLINICAL DATA, THIS 7105 04:07:08,249 --> 04:07:09,817 IS A VERY, VERY VIBRANT FIELD OF 7106 04:07:09,817 --> 04:07:10,251 ACTIVITY. 7107 04:07:10,251 --> 04:07:12,219 BUT IT IS VERY FAR OFF FROM WHAT 7108 04:07:12,219 --> 04:07:13,921 WE'RE SEEING IN CLINICAL 7109 04:07:13,921 --> 04:07:14,188 PRACTICE. 7110 04:07:14,188 --> 04:07:17,825 SO OUR FUNDAMENTAL CHALLENGE IS 7111 04:07:17,825 --> 04:07:19,593 TO TAKE THIS MULTIMODAL DATA AND 7112 04:07:19,593 --> 04:07:21,829 INTEGRATE IT IN SUCH A WAY AS TO 7113 04:07:21,829 --> 04:07:24,131 IMPROVE PROGNOSIS AND DIAGNOSIS 7114 04:07:24,131 --> 04:07:26,000 FOR PATIENTS, DO IT IN A 7115 04:07:26,000 --> 04:07:28,069 VALIDATED WAY, VERIFY ALGORITHMS 7116 04:07:28,069 --> 04:07:30,071 THAT ARE BEING DEVELOPED, AND 7117 04:07:30,071 --> 04:07:31,906 DISTRIBUTE THEM FAIRLY AND 7118 04:07:31,906 --> 04:07:33,774 EQUITABLY FOR ALL PATIENTS WHO 7119 04:07:33,774 --> 04:07:36,110 WILL BENEFIT FROM THEM. 7120 04:07:36,110 --> 04:07:37,745 SO THAT'S FAR OFF FROM WHERE WE 7121 04:07:37,745 --> 04:07:39,280 ARE IN THE RESEARCH COMMUNITY, 7122 04:07:39,280 --> 04:07:41,716 BUT WE BELIEVE THIS IS A UNIQUE 7123 04:07:41,716 --> 04:07:43,351 MOMENT WHERE WE CAN LEVERAGE 7124 04:07:43,351 --> 04:07:44,885 SIGNIFICANT ADVANCES IN MANY OF 7125 04:07:44,885 --> 04:07:46,320 THE DIFFERENT TECHNOLOGIES THAT 7126 04:07:46,320 --> 04:07:48,723 GO INTO THIS CONCEPT FROM THE 7127 04:07:48,723 --> 04:07:50,524 IMAGING METHODS THEMSELVES TO 7128 04:07:50,524 --> 04:07:52,159 THE DATA SCIENCE AND 7129 04:07:52,159 --> 04:07:53,594 COMPUTATIONAL METHODS FOR 7130 04:07:53,594 --> 04:07:55,363 EXTRACTING INFORMATION CONTENT, 7131 04:07:55,363 --> 04:07:57,665 TO MULTIMODAL TYPES OF LEARNING 7132 04:07:57,665 --> 04:08:00,067 STRATEGIES THAT INTEGRATE VERY 7133 04:08:00,067 --> 04:08:01,669 BEAUTIFUL IMAGING TYPES OF 7134 04:08:01,669 --> 04:08:03,637 APPROACHES WITH OUR CLINICAL 7135 04:08:03,637 --> 04:08:05,072 INFORMATION CONTENT AND LAB TEST 7136 04:08:05,072 --> 04:08:06,607 RESULTS, WHICH TEND TO BE LOWER 7137 04:08:06,607 --> 04:08:09,043 BIT RATE INFORMATION, BUT 7138 04:08:09,043 --> 04:08:10,778 COMBINED WITH IMAGING WHERE WE 7139 04:08:10,778 --> 04:08:12,980 COULD POTENTIALLY EXTRACT VERY, 7140 04:08:12,980 --> 04:08:15,282 VERY HIGH MEGABYTE, GIGABYTE 7141 04:08:15,282 --> 04:08:16,684 INFORMATION CONTENT, WE COULD DO 7142 04:08:16,684 --> 04:08:18,519 THINGS, I THINK, THAT ARE VERY 7143 04:08:18,519 --> 04:08:20,154 UNUSUAL AND POWERFUL AND 7144 04:08:20,154 --> 04:08:25,359 TRANSFORMATIVE FOR PATIENTS. 7145 04:08:25,359 --> 04:08:29,063 ONE OF THE THINGS THATTING WE TR 7146 04:08:29,063 --> 04:08:30,531 ABOUT ALL THE TIME WITH COMMON 7147 04:08:30,531 --> 04:08:31,999 FUND PROGRAMS IS ARE WE DOING 7148 04:08:31,999 --> 04:08:32,633 THIS ALREADY. 7149 04:08:32,633 --> 04:08:33,634 THE ANSWER IS KIND OF YES AND 7150 04:08:33,634 --> 04:08:34,168 NO. 7151 04:08:34,168 --> 04:08:35,870 SO THIS SLIDE, THE TOP PLOT 7152 04:08:35,870 --> 04:08:39,707 SHOWS THE EXPANSIVE GROWTH OF AI 7153 04:08:39,707 --> 04:08:41,909 AND ML, DEEP LEARNING TECHNIQUES 7154 04:08:41,909 --> 04:08:46,447 ACROSS THE NIH, MORE THAN 6,000 7155 04:08:46,447 --> 04:08:47,748 TYPE 1 GRANTS INTEGRATED OVER 7156 04:08:47,748 --> 04:08:49,250 THAT FIVE-YEAR INTERVAL FROM 7157 04:08:49,250 --> 04:08:52,286 2019 TO 2023, BUT ONCE YOU START 7158 04:08:52,286 --> 04:08:55,056 TO NARROW THIS DOWN AND LOOK AT 7159 04:08:55,056 --> 04:08:56,357 THIS IN COMBINATION WITH 7160 04:08:56,357 --> 04:08:58,292 CLINICAL IMAGING, WE REDUCE THAT 7161 04:08:58,292 --> 04:09:01,996 ONLY TO ABOUT 2,000 TYPE 7162 04:09:01,996 --> 04:09:03,064 1 GRANTS INTEGRATED OVER THAT 7163 04:09:03,064 --> 04:09:03,631 ENTIRE FIVE YEARS. 7164 04:09:03,631 --> 04:09:05,399 AND THEN IF YOU LOOK AT HOW 7165 04:09:05,399 --> 04:09:07,168 THESE WILL COME TOGETHER WITH 7166 04:09:07,168 --> 04:09:09,670 PRECISION MEDICINE, IT'S EVEN 7167 04:09:09,670 --> 04:09:10,438 FEWER. 7168 04:09:10,438 --> 04:09:11,639 THE GRANT TOTAL IS IN THE 7169 04:09:11,639 --> 04:09:13,307 HUNDREDS. 7170 04:09:13,307 --> 04:09:15,009 SO THIS SAYS A COUPLE OF THINGS. 7171 04:09:15,009 --> 04:09:18,279 THERE IS A SIGNIFICANT AMOUNT OF 7172 04:09:18,279 --> 04:09:19,547 INTEREST AND INVESTMENT IN THE 7173 04:09:19,547 --> 04:09:20,948 FUNDAMENTAL TECHNIQUES THAT ARE 7174 04:09:20,948 --> 04:09:22,817 DRIVING AI, MACHINE LEARNING AND 7175 04:09:22,817 --> 04:09:24,285 DEEP LEARNING, BUT THEY'RE KIND 7176 04:09:24,285 --> 04:09:25,486 OF SILOED FROM ONE ANOTHER. 7177 04:09:25,486 --> 04:09:27,154 SO WE HAVE INFRASTRUCTURE AND 7178 04:09:27,154 --> 04:09:29,423 CAPACITY ALL AROUND THE COUNTRY 7179 04:09:29,423 --> 04:09:31,092 IN THESE CORE TECHNICAL AREAS, 7180 04:09:31,092 --> 04:09:33,294 BUT WE DON'T HAVE A COHESIVE 7181 04:09:33,294 --> 04:09:34,261 STRUCTURE TO BRING THEM ALL 7182 04:09:34,261 --> 04:09:37,264 TOGETHER. 7183 04:09:37,264 --> 04:09:39,133 SO THIS SUGGESTS TO US THERE ARE 7184 04:09:39,133 --> 04:09:40,968 KEY OPPORTUNITIES HERE FOR 7185 04:09:40,968 --> 04:09:42,670 FEDERAL AND NON-FEDERAL 7186 04:09:42,670 --> 04:09:43,237 PARTNERSHIPS THAT COULD MAKE 7187 04:09:43,237 --> 04:09:51,011 THIS INITIATIVE QUITE POWERFUL. 7188 04:09:51,011 --> 04:09:54,081 DOLLARS IN OUR NEXT STEP OF 7189 04:09:54,081 --> 04:09:55,249 EVALUATING IS THIS SOMETHING 7190 04:09:55,249 --> 04:09:57,618 UNIQUE, IS THIS A FIGUREMENT OF 7191 04:09:57,618 --> 04:10:00,221 OUR IMAGINATION, WE THINK IT'S 7192 04:10:00,221 --> 04:10:01,122 IMPORTANT SO THEREFORE WE WANT 7193 04:10:01,122 --> 04:10:02,123 TO MOVE IT FORWARD. 7194 04:10:02,123 --> 04:10:05,025 WE DID A PUBLIC RFI AND HEALTH A 7195 04:10:05,025 --> 04:10:06,327 STROO STRATEGIC PLANNING 7196 04:10:06,327 --> 04:10:08,028 WORKSHOP MARCH 11TH AND 12TH. 7197 04:10:08,028 --> 04:10:10,898 BOTH OF THESE PROVIDED ENORMOUS 7198 04:10:10,898 --> 04:10:11,732 RESPONSE AND INFORMATION 7199 04:10:11,732 --> 04:10:13,033 CONTENT. 7200 04:10:13,033 --> 04:10:14,635 OVER A THOUSAND PARTICIPANTS 7201 04:10:14,635 --> 04:10:14,969 ENGAGED. 7202 04:10:14,969 --> 04:10:16,170 WE HADN'T ANNOUNCED THE 7203 04:10:16,170 --> 04:10:19,773 INITIATIVE AT ALL, JUST THE 7204 04:10:19,773 --> 04:10:20,508 IDEAS BEHIND THE INITIATIVE, 7205 04:10:20,508 --> 04:10:22,343 WHAT WERE THESE KEY IDEAS. 7206 04:10:22,343 --> 04:10:24,178 BASED ON THE PUBLIC RFI, OUR 7207 04:10:24,178 --> 04:10:26,413 TEAM REALLY EXTRACTED FOUR MAJOR 7208 04:10:26,413 --> 04:10:30,184 THEMES. 7209 04:10:30,184 --> 04:10:31,585 IMAGING AND MULTIMODAL 7210 04:10:31,585 --> 04:10:32,887 INTEGRATION, AI ALGORITHM AND 7211 04:10:32,887 --> 04:10:37,158 TOOL DEVELOPMENT, CLINICAL 7212 04:10:37,158 --> 04:10:37,925 IMPLEMENTATION, AND BUILDING 7213 04:10:37,925 --> 04:10:39,026 TRUST AND COORDINATION. 7214 04:10:39,026 --> 04:10:42,863 AND THESE ARE THE FOUR 7215 04:10:42,863 --> 04:10:44,064 FOUNDATIONAL ELEMENTS OF OUR 7216 04:10:44,064 --> 04:10:45,432 PROGRAM, AND IF WE GO TO THE 7217 04:10:45,432 --> 04:10:49,670 NEXT SLIDE, MIKE WILL TAKE IT 7218 04:10:49,670 --> 04:10:52,740 FROM HERE AND EXPAND INTO ALL OF 7219 04:10:52,740 --> 04:10:54,942 THOSE ELEMENTS OF THE PROGRAM. 7220 04:10:54,942 --> 04:10:56,911 >> BRUCE, THANK YOU. 7221 04:10:56,911 --> 04:11:00,614 SO BASICALLY THIS SLIDE TALKS 7222 04:11:00,614 --> 04:11:02,149 ABOUT BASICALLY THESE UNMET 7223 04:11:02,149 --> 04:11:03,784 NEEDS THAT FOLLOW NATURALLY FROM 7224 04:11:03,784 --> 04:11:05,352 WHAT BRUCE JUST TALKED ABOUT. 7225 04:11:05,352 --> 04:11:06,687 I'M JUST GOING TO TAKE YOU 7226 04:11:06,687 --> 04:11:08,088 THROUGH THESE BULLET POINTS 7227 04:11:08,088 --> 04:11:08,422 QUICKLY. 7228 04:11:08,422 --> 04:11:10,791 IF YOU LOOK AT THE FIRST BULLET 7229 04:11:10,791 --> 04:11:12,660 POINT AND THE THIRD BULLET 7230 04:11:12,660 --> 04:11:14,828 POINT, THEY BASICALLY TALK ABOUT 7231 04:11:14,828 --> 04:11:17,264 AN UNMET NEED GOING FROM SINGLE 7232 04:11:17,264 --> 04:11:20,768 MODALITY DATA TO MULTI-MODALITY 7233 04:11:20,768 --> 04:11:22,970 DATA, AND LINKING THOSE DATA 7234 04:11:22,970 --> 04:11:24,972 ACROSS THE DIFFERENT SCALES FROM 7235 04:11:24,972 --> 04:11:26,974 MOLECULES UP TO PATIENTS TO 7236 04:11:26,974 --> 04:11:28,943 POPULATIONS. 7237 04:11:28,943 --> 04:11:31,011 THE SECOND BULLET POINT HERE 7238 04:11:31,011 --> 04:11:33,414 TALKS ABOUT ADDRESSING THESE 7239 04:11:33,414 --> 04:11:35,249 UNMET NEEDS AND GAPS INVOLVING, 7240 04:11:35,249 --> 04:11:37,451 FOR EXAMPLE, INTEROPERABILITY 7241 04:11:37,451 --> 04:11:38,652 AND HARMONIZATION THAT ARE GOING 7242 04:11:38,652 --> 04:11:42,089 TO MOVE US TOWARD ADVANCING 7243 04:11:42,089 --> 04:11:44,291 AI-DRIVEN PRECISION MEDICINE FOR 7244 04:11:44,291 --> 04:11:47,061 ALL AMERICANS, AND THE BOTTOM 7245 04:11:47,061 --> 04:11:48,395 TWO BULLET POINTS TALK ABOUT 7246 04:11:48,395 --> 04:11:50,030 REAL WORLD IMPLEMENTATION, 7247 04:11:50,030 --> 04:11:52,333 GETTING THESE AI TOOLS INTO 7248 04:11:52,333 --> 04:11:53,200 CLINICAL DECISION SUPPORT TOOLS 7249 04:11:53,200 --> 04:11:55,536 THAT COULD BE USED BY CLINICIANS 7250 04:11:55,536 --> 04:11:57,204 USING ELECTRONIC HEALTH RECORDS, 7251 04:11:57,204 --> 04:11:58,839 AND BUILDING ALL THOSE 7252 04:11:58,839 --> 04:12:00,007 RELATIONSHIPS AMONG THE 7253 04:12:00,007 --> 04:12:00,774 STAKEHOLDERS. 7254 04:12:00,774 --> 04:12:02,076 PATIENT, CLINICIANS, DATA 7255 04:12:02,076 --> 04:12:02,376 SCIENTISTS. 7256 04:12:02,376 --> 04:12:04,011 THAT ARE GOING TO BE NEEDED TO 7257 04:12:04,011 --> 04:12:05,613 REALLY MOVE THE FIELD FORWARD. 7258 04:12:05,613 --> 04:12:06,947 SO IF YOU CAN GO TO THE NEXT 7259 04:12:06,947 --> 04:12:12,086 SLIDE, PLEASE. 7260 04:12:12,086 --> 04:12:13,687 IN THIS SLIDE, WHAT WE REALLY 7261 04:12:13,687 --> 04:12:15,589 TALK ABOUT IS MOVING FROM BLUE 7262 04:12:15,589 --> 04:12:17,157 SKY TO MAKE IT A LITTLE BIT MORE 7263 04:12:17,157 --> 04:12:20,060 TANGIBLE. 7264 04:12:20,060 --> 04:12:23,931 SO HERE, WE DESCRIBE A SERIES OF 7265 04:12:23,931 --> 04:12:26,300 NOFOs THAT ARE INTENDED TO 7266 04:12:26,300 --> 04:12:28,235 ADDRESS FOUR ITERATIVE SUBGOALS. 7267 04:12:28,235 --> 04:12:31,405 AND THESE GOALS ARE COLOR-CODED. 7268 04:12:31,405 --> 04:12:35,209 SO GOING FROM LEFT TO RIGHT, AT 7269 04:12:35,209 --> 04:12:37,711 THE UPPER LEFT, THERE IS 7270 04:12:37,711 --> 04:12:38,646 INTEGRATION OF IMAGE DATA 7271 04:12:38,646 --> 04:12:42,283 TOGETHER WITH MULTIMODAL DATA. 7272 04:12:42,283 --> 04:12:45,586 SO THAT'S -- THE MULTIMODAL DATA 7273 04:12:45,586 --> 04:12:47,488 COULD BE CLINICAL DATA, GENETIC 7274 04:12:47,488 --> 04:12:50,424 DATA, MULTI-OMIC DATA, SO THEN 7275 04:12:50,424 --> 04:12:52,559 UP IN THE BLUE, ON THE UPPER 7276 04:12:52,559 --> 04:12:54,728 RIGHT IS BUILDING THOSE AI 7277 04:12:54,728 --> 04:12:56,163 ALGORITHMS AND TOOLS. 7278 04:12:56,163 --> 04:12:58,365 AND THOSE TOOLS COULD BE USED TO 7279 04:12:58,365 --> 04:13:00,200 DO THINGS LIKE CLINICAL 7280 04:13:00,200 --> 04:13:02,503 DIAGNOSIS, PATIENT MANAGEMENT, 7281 04:13:02,503 --> 04:13:05,439 PREDICTION OF FUTURE DISEASE. 7282 04:13:05,439 --> 04:13:07,474 SO THEN GOING DOWN TO THE LOWER 7283 04:13:07,474 --> 04:13:09,209 LEFT, CLINICAL IMPLEMENTATION, 7284 04:13:09,209 --> 04:13:11,945 THIS IS ALL THAT REAL WORLD 7285 04:13:11,945 --> 04:13:13,480 IMPLEMENTATION THAT WE TALKED 7286 04:13:13,480 --> 04:13:15,382 ABOUT, AND IN THE GREEN AT THE 7287 04:13:15,382 --> 04:13:17,051 BOTTOM RIGHT IS TRUST, AND 7288 04:13:17,051 --> 04:13:18,886 YOU'LL SEE ON THE DIAGRAM THE 7289 04:13:18,886 --> 04:13:20,421 TRUST ENCOMPASSES EVERYTHING. 7290 04:13:20,421 --> 04:13:23,524 AND WHAT DO WE MEAN BY THAT? 7291 04:13:23,524 --> 04:13:26,060 PROGRAM COHESION, ADAPTABILITY, 7292 04:13:26,060 --> 04:13:28,128 SCIENTIFIC VALIDATION AND RIGOR, 7293 04:13:28,128 --> 04:13:30,364 AND TRANSPARENCY. 7294 04:13:30,364 --> 04:13:32,700 SO JUST KEEP IN MIND THAT THESE 7295 04:13:32,700 --> 04:13:35,002 CONCEPTS DON'T WORK IN ISOLATION 7296 04:13:35,002 --> 04:13:36,337 FROM ONE ANOTHER. 7297 04:13:36,337 --> 04:13:36,937 LIKE FOR EXAMPLE, THERE'S NOT 7298 04:13:36,937 --> 04:13:38,539 GOING TO BE A YELLOW NOFO AND A 7299 04:13:38,539 --> 04:13:39,740 BLUE NOFO. 7300 04:13:39,740 --> 04:13:42,776 IN REALITY, THESE SUBCONCEPT ARE 7301 04:13:42,776 --> 04:13:44,178 PRETTY HEAVILY INTERRELATED, AND 7302 04:13:44,178 --> 04:13:46,080 SO WHAT I WANT TO DO, IF YOU CAN 7303 04:13:46,080 --> 04:13:48,115 GO TO THE NEXT SLIDE, WHAT WE'RE 7304 04:13:48,115 --> 04:13:49,516 DOING IS TAKING ALL THESE 7305 04:13:49,516 --> 04:13:51,485 CIRCLES AND BASICALLY FLATTENING 7306 04:13:51,485 --> 04:13:52,820 THEM, AND THIS IS GOING TO BE A 7307 04:13:52,820 --> 04:13:54,755 LITTLE BIT EVEN MORE TANGIBLE 7308 04:13:54,755 --> 04:13:57,358 ABOUT THE ACTUAL NOFOs. 7309 04:13:57,358 --> 04:13:59,693 SAME COLOR CODING IS ON THE 7310 04:13:59,693 --> 04:14:01,228 PREVIOUS SLIDE, AND GOING FROM 7311 04:14:01,228 --> 04:14:03,964 TOP TO BOTTOM, THE DATA 7312 04:14:03,964 --> 04:14:05,833 INTEGRATION IS IN YELLOW, AND 7313 04:14:05,833 --> 04:14:07,835 HERE THERE WOULD BE THREE SETS 7314 04:14:07,835 --> 04:14:09,570 OF NOFOs THAT WE WOULD REALLY 7315 04:14:09,570 --> 04:14:11,338 PROPOSE. 7316 04:14:11,338 --> 04:14:15,275 ONE IS WHAT WE'RE CALLING A 7317 04:14:15,275 --> 04:14:16,610 PLAYBOOK OF STANDARDIZED FRAME 7318 04:14:16,610 --> 04:14:18,479 WORKS. 7319 04:14:18,479 --> 04:14:20,881 AND HERE, THE WAY THIS WOULD 7320 04:14:20,881 --> 04:14:23,183 REALLY WORK IS THAT THESE 7321 04:14:23,183 --> 04:14:24,718 PLAYBOOKS WOULD DESCRIBE 7322 04:14:24,718 --> 04:14:26,553 ESSENTIALLY BEST PRACTICES FOR 7323 04:14:26,553 --> 04:14:28,522 BUILDING MULTIMODAL AI SYSTEMS 7324 04:14:28,522 --> 04:14:30,424 FOR DIFFERENT USE CASES, SO 7325 04:14:30,424 --> 04:14:31,759 INVESTIGATORS COULD USE THIS 7326 04:14:31,759 --> 04:14:33,060 PLAYBOOK TO GET HELP WITH A 7327 04:14:33,060 --> 04:14:36,029 RANGE OF CHALLENGES FROM BEST 7328 04:14:36,029 --> 04:14:39,032 PRACTICES FOR VALIDATION OF AI 7329 04:14:39,032 --> 04:14:41,201 ALGORITHMS TO IDENTIFYING 7330 04:14:41,201 --> 04:14:42,970 INDICATIONS FOR USE FOR CLINICAL 7331 04:14:42,970 --> 04:14:44,238 IMPLEMENTATION TO NAVIGATING 7332 04:14:44,238 --> 04:14:45,339 REGULATORY HURDLES. 7333 04:14:45,339 --> 04:14:48,142 SO THE NEXT ROW HERE IS 7334 04:14:48,142 --> 04:14:48,909 ACADEMIC-INDUSTRIAL 7335 04:14:48,909 --> 04:14:49,410 PARTNERSHIPS. 7336 04:14:49,410 --> 04:14:50,177 AND THAT REALLY GET INTO WHAT 7337 04:14:50,177 --> 04:14:52,479 BRUCE WAS TALKING ABOUT, ABOUT 7338 04:14:52,479 --> 04:14:53,680 BUILDING COLLABORATIONS AND 7339 04:14:53,680 --> 04:14:55,249 GETTING STUFF INTO THE REAL 7340 04:14:55,249 --> 04:14:55,816 WORLD. 7341 04:14:55,816 --> 04:14:58,118 AND THE LAST OF THESE IS A SET 7342 04:14:58,118 --> 04:15:00,187 OF NOFOs TO DEVELOP MODULAR 7343 04:15:00,187 --> 04:15:00,754 SOFTWARE TOOLS. 7344 04:15:00,754 --> 04:15:02,456 SO THERE WOULD BE A LOT OF 7345 04:15:02,456 --> 04:15:04,324 TOOLS, AND WE WOULD INTEND TO 7346 04:15:04,324 --> 04:15:08,362 FUND ABOUT 40 PROJECTS IN THIS 7347 04:15:08,362 --> 04:15:09,963 AREA, AND SOME OF THESE TOOLS 7348 04:15:09,963 --> 04:15:12,032 WOULD BE TO -- SO THE IDEA IS 7349 04:15:12,032 --> 04:15:14,234 THAT THEY WOULD BE RE-USED BY A 7350 04:15:14,234 --> 04:15:15,936 LOT OF DIFFERENT GROUPS AROUND 7351 04:15:15,936 --> 04:15:16,236 THE COUNTRY. 7352 04:15:16,236 --> 04:15:18,038 THEY COULD BE USED FOR 7353 04:15:18,038 --> 04:15:22,075 MULTIMODAL DATA INTEGRATION, FOR 7354 04:15:22,075 --> 04:15:23,877 EVALUATING THE ROBUSTNESS OF 7355 04:15:23,877 --> 04:15:26,613 MODELS OR TO BASICALLY DEVELOP 7356 04:15:26,613 --> 04:15:28,482 BETTER USER INTERFACE DESIGN 7357 04:15:28,482 --> 04:15:29,616 WIDGETS. 7358 04:15:29,616 --> 04:15:30,484 SO A LOT OF THESE MODULAR 7359 04:15:30,484 --> 04:15:37,357 SOFTWARE TOOLS. 7360 04:15:37,357 --> 04:15:39,460 THE RED HERE IS THOSE CLINICAL 7361 04:15:39,460 --> 04:15:43,096 IMPLEMENTATION AND TESTING 7362 04:15:43,096 --> 04:15:43,330 PHASE. 7363 04:15:43,330 --> 04:15:45,299 AND HERE, THERE'S A SINGLE NOFO 7364 04:15:45,299 --> 04:15:46,700 THAT'S CALLED THE MODEL TO 7365 04:15:46,700 --> 04:15:48,435 CLINIC NOFO THAT'S THE SINGLE 7366 04:15:48,435 --> 04:15:49,403 BIGGEST ONE IN THIS PROJECT. 7367 04:15:49,403 --> 04:15:51,805 AND I'M GOING TO TALK ABOUT IN 7368 04:15:51,805 --> 04:15:55,542 THE NEXT SLIDE, SO IF YOU COULD 7369 04:15:55,542 --> 04:15:56,376 PUSH ONCE MORE. 7370 04:15:56,376 --> 04:15:57,444 THE LAST OF THESE IS THAT 7371 04:15:57,444 --> 04:15:59,213 THERE'S THE TRUST SET OF 7372 04:15:59,213 --> 04:16:00,280 NOFOs, AND YOU NOTICE HERE 7373 04:16:00,280 --> 04:16:02,049 AGAIN THAT IT ENCOMPASSES ALL 7374 04:16:02,049 --> 04:16:04,651 THE OTHER PROJECTS, AND HERE WE 7375 04:16:04,651 --> 04:16:06,119 ENVISION THIS AS A SERIES OF 7376 04:16:06,119 --> 04:16:08,121 THREE CENTERS BASICALLY. 7377 04:16:08,121 --> 04:16:11,191 ONE IS A VALIDATION CENTER FOR 7378 04:16:11,191 --> 04:16:12,359 DOING VERIFICATION AND 7379 04:16:12,359 --> 04:16:13,460 VALIDATION INDEPENDENTLY OF THE 7380 04:16:13,460 --> 04:16:16,497 TOOLS THAT ARE DEVELOPED THROUGH 7381 04:16:16,497 --> 04:16:17,698 PRIMED AI. 7382 04:16:17,698 --> 04:16:19,900 THE NEXT SET IN THE MIDDLE IS A 7383 04:16:19,900 --> 04:16:21,401 LOGISTICS CENTER, AND THAT'S 7384 04:16:21,401 --> 04:16:23,036 BASICALLY GOING TO DO ALL THE 7385 04:16:23,036 --> 04:16:24,371 PROGRAM ADMINISTRATION AND 7386 04:16:24,371 --> 04:16:25,906 TEAMING SUPPORT AND ENGAGEMENT 7387 04:16:25,906 --> 04:16:27,174 WITH STAKEHOLDER COMMUNITIES 7388 04:16:27,174 --> 04:16:28,609 THAT'S GOING TO BE SO IMPORTANT 7389 04:16:28,609 --> 04:16:30,010 FOR A PROJECT LIKE THIS. 7390 04:16:30,010 --> 04:16:31,979 AND LASTLY, ON THE BOTTOM RIGHT 7391 04:16:31,979 --> 04:16:34,448 OF THE SLIDE IS COMMUNICATION 7392 04:16:34,448 --> 04:16:35,115 CURRICULA NOFOs. 7393 04:16:35,115 --> 04:16:36,416 AND THESE ARE BASICALLY GOING TO 7394 04:16:36,416 --> 04:16:41,121 BE NOFOs TO DEVELOP STRATEGIES 7395 04:16:41,121 --> 04:16:43,724 TO BUILD COMMUNICATION AND TRUST 7396 04:16:43,724 --> 04:16:45,158 AMONG DATA SCIENTISTS, 7397 04:16:45,158 --> 04:16:46,159 CLINICIANS AND PATIENTS. 7398 04:16:46,159 --> 04:16:47,060 AGAIN, WE THINK THAT'S REALLY 7399 04:16:47,060 --> 04:16:48,729 GOING TO BE IMPORTANT FOR A 7400 04:16:48,729 --> 04:16:50,030 PROJECT LIKE THIS. 7401 04:16:50,030 --> 04:16:51,798 IF YOU CAN GO TO THE NEXT SLIDE, 7402 04:16:51,798 --> 04:16:52,666 PLEASE. 7403 04:16:52,666 --> 04:16:54,434 AND THIS SLIDE, WHAT WE REALLY 7404 04:16:54,434 --> 04:16:58,438 GIVE IS MORE DETAILS ABOUT HOW 7405 04:16:58,438 --> 04:17:00,941 THIS MODEL TO CLINIC NOFO WOULD 7406 04:17:00,941 --> 04:17:01,408 LOOK. 7407 04:17:01,408 --> 04:17:03,544 SO AGAIN, THIS IS THE SINGLE 7408 04:17:03,544 --> 04:17:05,279 BIGGEST SET OF NOFOs THAT 7409 04:17:05,279 --> 04:17:08,749 WE'RE PROPOSING IN PRIMED-AI. 7410 04:17:08,749 --> 04:17:10,384 THERE WOULD BE ABOUT 10 OF THESE 7411 04:17:10,384 --> 04:17:12,052 WE WOULD FUND AND THE TOTAL 7412 04:17:12,052 --> 04:17:13,887 INVESTMENT WOULD BE $50 MILLION 7413 04:17:13,887 --> 04:17:15,088 OVER FIVE YEARS. 7414 04:17:15,088 --> 04:17:18,625 SO WE ENVISION THIS OCCURRING IN 7415 04:17:18,625 --> 04:17:19,660 TWO PHASES. 7416 04:17:19,660 --> 04:17:20,661 PHASE ONE IS DEVELOPING THE 7417 04:17:20,661 --> 04:17:22,796 TOOLS AND PHASE TWO IS TESTING, 7418 04:17:22,796 --> 04:17:25,299 WHAT WE CALL ANCILLARY CLINICAL 7419 04:17:25,299 --> 04:17:26,266 TESTING. 7420 04:17:26,266 --> 04:17:28,702 SO AGAIN IT INTEGRATES ALL THE 7421 04:17:28,702 --> 04:17:38,912 YELLOWS, THE BLUES, THE GREENS 7422 04:17:38,912 --> 04:17:40,581 AND REDS FROM THE PREVIOUS 7423 04:17:40,581 --> 04:17:42,215 SLIDES. 7424 04:17:42,215 --> 04:17:44,585 ARE THE DATA CAN COME FROM 7425 04:17:44,585 --> 04:17:45,185 RETROSPECTIVE CLINICAL TRIALS, 7426 04:17:45,185 --> 04:17:47,854 AND WE WOULD DEVELOP TOOLS TO 7427 04:17:47,854 --> 04:17:49,923 INTEGRATE THOSE DATA AND MAKE 7428 04:17:49,923 --> 04:17:51,191 THEM INTEROPERABLE. 7429 04:17:51,191 --> 04:17:55,128 AND THEN MOVING TO THE BLUE, WE 7430 04:17:55,128 --> 04:17:56,997 WOULD BUILD AI ALGORITHMS TO 7431 04:17:56,997 --> 04:17:58,599 SOLVE DEFINED CLINICAL PROBLEMS. 7432 04:17:58,599 --> 04:18:03,170 AND OUR ANTICIPATE IS THAT WE 7433 04:18:03,170 --> 04:18:07,608 WOULD HAVE ESSENTIALLY A 7434 04:18:07,608 --> 04:18:10,911 GO/NO-GO FUNNEL, BAS BASE BENCHS 7435 04:18:10,911 --> 04:18:12,546 BASED ON PRELIMINARY TESTING 7436 04:18:12,546 --> 04:18:14,514 THAT WOULD PASS TO PHASE TWO 7437 04:18:14,514 --> 04:18:15,582 WHICH IS ANCILLARY CLINICAL 7438 04:18:15,582 --> 04:18:17,784 TESTING. 7439 04:18:17,784 --> 04:18:19,753 THE WAY THAT THIS WOULD WORK IS 7440 04:18:19,753 --> 04:18:26,159 THE RED BARS HERE WE WOULD 7441 04:18:26,159 --> 04:18:29,763 IDENTIFY MECHANISMS TO 7442 04:18:29,763 --> 04:18:30,430 PERFORMANCE LARRY TESTING AND 7443 04:18:30,430 --> 04:18:32,366 THEY COULD BE TESTED IN ACADEMIC 7444 04:18:32,366 --> 04:18:34,668 MEDICAL CENTERS, IN COMMUNITY 7445 04:18:34,668 --> 04:18:36,737 HOSPITALS, OR THEY COULD BE 7446 04:18:36,737 --> 04:18:38,472 USED, THEY COULD BE APPLIED, FOR 7447 04:18:38,472 --> 04:18:41,308 EXAMPLE, FOR EXISTING INDUSTRY 7448 04:18:41,308 --> 04:18:42,643 FUNDED CLINICAL TRIALS, WHERE WE 7449 04:18:42,643 --> 04:18:44,678 WOULD DEFINE NEW SECONDARY 7450 04:18:44,678 --> 04:18:46,847 OUTCOME MEASURES THAT PRIMED-AI 7451 04:18:46,847 --> 04:18:48,715 ALGORITHMS COULD APPLY TO. 7452 04:18:48,715 --> 04:18:50,817 SO WHAT WE'RE REALLY TRYING TO 7453 04:18:50,817 --> 04:18:53,320 DO IS TO CREATE OPPORTUNITIES TO 7454 04:18:53,320 --> 04:18:57,357 GET THIS INTO THE REAL WORLD, 7455 04:18:57,357 --> 04:18:59,660 AND AT THE BOTTOM IN THE GREEN, 7456 04:18:59,660 --> 04:19:01,161 THERE WOULD BE AN INDEPENDENT 7457 04:19:01,161 --> 04:19:02,229 MODEL TESTING THAT WOULD BE DONE 7458 04:19:02,229 --> 04:19:05,198 IN COORDINATION WITH THAT 7459 04:19:05,198 --> 04:19:06,400 VALIDATION CENTER, ONE OF THOSE 7460 04:19:06,400 --> 04:19:09,036 GREEN AREAS. 7461 04:19:09,036 --> 04:19:10,804 SO I REALLY WANT TO EMPHASIZE 7462 04:19:10,804 --> 04:19:12,305 THAT I HOPE IT COMES ACROSS THAT 7463 04:19:12,305 --> 04:19:13,640 THE DESIGN OF THIS IS REALLY 7464 04:19:13,640 --> 04:19:15,809 MEANT TO RESPECT THE FACT THAT 7465 04:19:15,809 --> 04:19:17,611 AI IS REALLY RAPIDLY EVOLVING, 7466 04:19:17,611 --> 04:19:19,146 IT A DYNAMIC FIELD, AND WE WANT 7467 04:19:19,146 --> 04:19:21,915 TO MAKE SURE THAT THIS ECOSYSTEM 7468 04:19:21,915 --> 04:19:24,451 OF PRIMED-AI PROJECTS LEAVES US 7469 04:19:24,451 --> 04:19:26,687 WITH THE FLEXIBILITY TO EVOLVE 7470 04:19:26,687 --> 04:19:27,788 THIS CONCEPT AS THE FIELD 7471 04:19:27,788 --> 04:19:29,623 EVOLVES. 7472 04:19:29,623 --> 04:19:31,925 WE REALLY WANT TO BE AGILE, 7473 04:19:31,925 --> 04:19:32,893 NIMBLE AND GIVE US THE 7474 04:19:32,893 --> 04:19:35,495 FLEXIBILITY TO PIVOT AS THE 7475 04:19:35,495 --> 04:19:40,333 FIELD CHANGES. 7476 04:19:40,333 --> 04:19:42,703 THIS NEXT SLIDE BASICALLY 7477 04:19:42,703 --> 04:19:43,336 SUMMARIZES THE BUDGET WE'RE 7478 04:19:43,336 --> 04:19:43,804 TALKING ABOUT. 7479 04:19:43,804 --> 04:19:45,672 SO IT'S $120 MILLION TOTAL 7480 04:19:45,672 --> 04:19:47,007 SPREAD OVER FIVE YEARS. 7481 04:19:47,007 --> 04:19:49,242 AND ALL THE NOFOs ARE DEFINED 7482 04:19:49,242 --> 04:19:50,410 THAT WE SHOWED ON THE PREVIOUS 7483 04:19:50,410 --> 04:19:53,680 SLIDES. 7484 04:19:53,680 --> 04:19:56,616 STARTING FROM THE PLAYBOOK, 7485 04:19:56,616 --> 04:19:57,918 YOU'LL NOTICE THE MODEL TO 7486 04:19:57,918 --> 04:20:00,620 CLINIC NOFO IS THE BIGGEST ONE, 7487 04:20:00,620 --> 04:20:02,622 10 AWARDS, $51 MILLION. 7488 04:20:02,622 --> 04:20:06,326 DOWN AT THE BOTTOM ARE THOSE 7489 04:20:06,326 --> 04:20:10,030 VALIDATION CENTER, LOGISTICS 7490 04:20:10,030 --> 04:20:10,363 CRITERIA. 7491 04:20:10,363 --> 04:20:11,565 THESE ARE THE DELIVERABLES AND 7492 04:20:11,565 --> 04:20:13,200 WE'RE REALLY EXCITED ABOUT THIS. 7493 04:20:13,200 --> 04:20:16,036 BEST PRACTICES FOR AI-BASED 7494 04:20:16,036 --> 04:20:17,537 PRECISION MEDICINE THROUGH 7495 04:20:17,537 --> 04:20:19,272 INTEGRATING IMAGING AND 7496 04:20:19,272 --> 04:20:20,774 MULTIMODAL DATA. 7497 04:20:20,774 --> 04:20:22,175 DEVELOPING A SET OF INNOVATIVE 7498 04:20:22,175 --> 04:20:23,944 AND RELIABLE TOOLS, AND LASTLY 7499 04:20:23,944 --> 04:20:26,046 AT THE BOTTOM, AND REALLY 7500 04:20:26,046 --> 04:20:27,314 IMPORTANTLY, DEVELOPING A SERIES 7501 04:20:27,314 --> 04:20:28,749 OF DURABLE RELATIONSHIPS THAT 7502 04:20:28,749 --> 04:20:30,183 ARE GOING TO SUSTAIN THE FIELD 7503 04:20:30,183 --> 04:20:31,785 AND HOPEFULLY EXPAND IT IN THE 7504 04:20:31,785 --> 04:20:32,018 FUTURE. 7505 04:20:32,018 --> 04:20:33,987 IF YOU GO TO THE LAST -- THE 7506 04:20:33,987 --> 04:20:35,822 NEXT SLIDE WHICH IS OUR LAST 7507 04:20:35,822 --> 04:20:37,891 SLIDE, THESE ARE THE TAKE-HOME 7508 04:20:37,891 --> 04:20:39,292 POINTS THAT BRUCE STARTED OUT BY 7509 04:20:39,292 --> 04:20:40,727 SAYING THAT WE'RE REALLY EXCITED 7510 04:20:40,727 --> 04:20:42,295 ABOUT THIS PROJECT, AND I WOULD 7511 04:20:42,295 --> 04:20:45,832 JUST FINISH BY SAYING THAT. 7512 04:20:45,832 --> 04:20:47,501 WE'VE GOT A LOT OF PEOPLE AT NIH 7513 04:20:47,501 --> 04:20:49,336 AND DIFFERENT INSTITUTES 7514 04:20:49,336 --> 04:20:50,203 INVOLVED, REALLY EXCITED ABOUT 7515 04:20:50,203 --> 04:20:52,706 THIS AS A COMMON FUND CONCEPT. 7516 04:20:52,706 --> 04:20:55,108 AI SUPPORTED TRANSLATIONAL 7517 04:20:55,108 --> 04:20:57,077 IMPACT FOR PATIENTS, TRYING TO 7518 04:20:57,077 --> 04:20:58,278 ADVANCE CULTURE CHANGE IN 7519 04:20:58,278 --> 04:21:00,247 CLINICAL PRACTICE BY ENABLING 7520 04:21:00,247 --> 04:21:02,082 PRECISION MEDICINE STRATEGIES AT 7521 04:21:02,082 --> 04:21:03,383 A LARGE SCALE AND GETTING INPUT 7522 04:21:03,383 --> 04:21:05,485 FROM ALL THE STAKEHOLDERS, AND 7523 04:21:05,485 --> 04:21:07,521 BASICALLY EXCEL RAIGHT THE USE 7524 04:21:07,521 --> 04:21:08,588 OF MULTI-SCALE DIGITAL 7525 04:21:08,588 --> 04:21:08,989 BIOMARKERS. 7526 04:21:08,989 --> 04:21:10,557 SO WITH THAT, I'M GOING TO STOP. 7527 04:21:10,557 --> 04:21:12,859 THANK YOU FOR YOUR ATTENTION, 7528 04:21:12,859 --> 04:21:15,061 AND NICOLE AND FRANZISKA, MAY WE 7529 04:21:15,061 --> 04:21:16,696 TURN TO YOU TO LEAD THIS 7530 04:21:16,696 --> 04:21:18,698 DISCUSSION? 7531 04:21:18,698 --> 04:21:20,934 >> THANK YOU BOTH VERY MUCH. 7532 04:21:20,934 --> 04:21:23,003 SO I WILL PASS IT OVER TO 7533 04:21:23,003 --> 04:21:23,436 DR. JOHNSON. 7534 04:21:23,436 --> 04:21:25,639 WOULD YOU PLEASE SHARE ANY 7535 04:21:25,639 --> 04:21:26,573 COMMENTS WITH THE COUNCIL? 7536 04:21:26,573 --> 04:21:28,241 >> I WOULD BE PLEASED TO. 7537 04:21:28,241 --> 04:21:31,745 FIRST OF ALL, I WANT TO APPLAUD 7538 04:21:31,745 --> 04:21:34,147 YOU BOTH FOR DEVELOPING THIS 7539 04:21:34,147 --> 04:21:35,949 CONCEPT AND REALLY THINKING 7540 04:21:35,949 --> 04:21:37,851 ABOUT IT AS AN ECOSYSTEM FOR THE 7541 04:21:37,851 --> 04:21:39,853 DEVELOPMENT AND ADOPTION OF 7542 04:21:39,853 --> 04:21:42,255 INNOVATIVE AI-BASED TOOLS. 7543 04:21:42,255 --> 04:21:43,323 THE GAP THAT WAS IDENTIFIED IN 7544 04:21:43,323 --> 04:21:44,658 THE RESEARCH RELATED TO 7545 04:21:44,658 --> 04:21:46,026 INTEGRATING IMAGING AND 7546 04:21:46,026 --> 04:21:47,093 MULTIMODAL DATA IS DEFINITELY 7547 04:21:47,093 --> 04:21:49,329 ONE THAT RESONATES WITH THE 7548 04:21:49,329 --> 04:21:50,530 COMMUNITY AT LARGE AS WELL AS IN 7549 04:21:50,530 --> 04:21:53,767 THE BRIDGE2AI AND INVESTIGATOR 7550 04:21:53,767 --> 04:21:54,134 COMMUNITY. 7551 04:21:54,134 --> 04:21:54,901 I DID NOTICE THAT IN THE GAP, 7552 04:21:54,901 --> 04:21:56,002 THERE'S A COUPLE THINGS YOU 7553 04:21:56,002 --> 04:21:56,503 DIDN'T DISCUSS. 7554 04:21:56,503 --> 04:22:01,875 I'M GOING TO COME BACK TO THOSE. 7555 04:22:01,875 --> 04:22:02,876 MY PRESENTATION IS GOING TO BE A 7556 04:22:02,876 --> 04:22:03,944 LITTLE BIT SCATTERED BECAUSE IT 7557 04:22:03,944 --> 04:22:05,178 TURNS OUT THAT THE SLIDES NEEDED 7558 04:22:05,178 --> 04:22:07,247 TO BE TALKED THROUGH, NOT SHOWN, 7559 04:22:07,247 --> 04:22:08,782 AS I THINK YOU PROBABLY KNOW. 7560 04:22:08,782 --> 04:22:10,884 AND SO NOW THAT I'VE HEARD IT, I 7561 04:22:10,884 --> 04:22:11,518 WROTE SOME NOTES THAT I WANTED 7562 04:22:11,518 --> 04:22:12,752 TO MAKE SURE I INCLUDED. 7563 04:22:12,752 --> 04:22:16,156 FIRST OF ALL, THE IDEA OF THE 7564 04:22:16,156 --> 04:22:17,524 FOUR SUBGOALS THAT ARE 7565 04:22:17,524 --> 04:22:19,092 SUMMARIZED BY THE TEAM WERE 7566 04:22:19,092 --> 04:22:20,493 EXACTLY THE HIGH LEVEL ASPECTS 7567 04:22:20,493 --> 04:22:22,128 THAT WOULD BE NEEDED TO HAVE 7568 04:22:22,128 --> 04:22:23,797 TRANSLATION AND IMPACT FROM 7569 04:22:23,797 --> 04:22:25,532 THINGS LIKE PRECISION MEDICINE 7570 04:22:25,532 --> 04:22:27,167 USING AI. 7571 04:22:27,167 --> 04:22:30,003 I WOULD NOTE, THOUGH, THAT EVERY 7572 04:22:30,003 --> 04:22:31,671 SINGLE ONE OF THE WORDS THAT'S 7573 04:22:31,671 --> 04:22:33,540 BOLDED IS FRANKLY UP FOR DEBATE 7574 04:22:33,540 --> 04:22:36,276 IN TERMS OF ITS OVERALL UTILITY. 7575 04:22:36,276 --> 04:22:37,277 SO I THINK IT GOING TO BE 7576 04:22:37,277 --> 04:22:39,246 IMPORTANT TO ASK THOSE 7577 04:22:39,246 --> 04:22:42,649 QUESTIONS, IN MY OPINION, 7578 04:22:42,649 --> 04:22:44,551 FEDERATED LEARN WILLING. 7579 04:22:44,551 --> 04:22:45,552 WHILE FEDERATED LEARNING HAS A 7580 04:22:45,552 --> 04:22:47,821 ROLE IN PRIVACY IT ALSO HAS THE 7581 04:22:47,821 --> 04:22:49,789 OPPORTUNITY TO STIFLE INNOVATION 7582 04:22:49,789 --> 04:22:50,891 AS WE'VE LEARNED EVEN FROM 7583 04:22:50,891 --> 04:22:51,524 THINGS LIKE ODYSSEY. 7584 04:22:51,524 --> 04:22:53,727 SO YOU GUYS KNOW THAT, MANY OF 7585 04:22:53,727 --> 04:22:56,963 THE WORDS THAT YOU'LL SEE IN THE 7586 04:22:56,963 --> 04:22:57,964 ORIGINAL CONCEPT PROBABLY SHOULD 7587 04:22:57,964 --> 04:23:00,033 BE DISCUSSED AS INDIVIDUAL IDEAS 7588 04:23:00,033 --> 04:23:01,768 AND I'M SURE THEY WILL BE AS 7589 04:23:01,768 --> 04:23:03,737 THIS CONCEPT KIND OF EVOLVES A 7590 04:23:03,737 --> 04:23:05,372 BIT. 7591 04:23:05,372 --> 04:23:08,541 THE OTHER THING IS, I DIDN'T 7592 04:23:08,541 --> 04:23:10,277 QUITE SEE ENOUGH ABOUT WHAT WAS 7593 04:23:10,277 --> 04:23:12,579 LEARNED FROM BRIDGE2AI. 7594 04:23:12,579 --> 04:23:14,547 I WENT THROUGH THE RFI, I SAW A 7595 04:23:14,547 --> 04:23:16,816 LITTLE BIT BUT I STILL REALIZE 7596 04:23:16,816 --> 04:23:18,685 THAT BRIRNLG TO AI IS ONGOING 7597 04:23:18,685 --> 04:23:20,320 BUT IT APPEARS THEY HAVE A LOT 7598 04:23:20,320 --> 04:23:21,621 OF LESSONS. 7599 04:23:21,621 --> 04:23:23,690 SOME OF THEM ARE IN HERE, AND 7600 04:23:23,690 --> 04:23:26,426 THEY HAVE BEEN ITTIVELY APPLIED 7601 04:23:26,426 --> 04:23:27,727 TO THIS PROPOSAL'S REQUIREMENTS, 7602 04:23:27,727 --> 04:23:28,828 BUT SOME OF THEM ARE NOT. 7603 04:23:28,828 --> 04:23:30,697 SO I JUST THOUGHT IT WOULD BE 7604 04:23:30,697 --> 04:23:31,898 USEFUL TO MAKE SURE THAT YOU'VE 7605 04:23:31,898 --> 04:23:32,532 EXPOSED THAT. 7606 04:23:32,532 --> 04:23:34,901 AND IF I MISSED SOMETHING, I 7607 04:23:34,901 --> 04:23:35,268 APOLOGIZE THERE. 7608 04:23:35,268 --> 04:23:37,103 IT SEEMS TO ME THAT THE 7609 04:23:37,103 --> 04:23:39,539 COMMUNICATION CURRICULA AND THE 7610 04:23:39,539 --> 04:23:40,607 LOGISTICS CENTER ARE REALLY 7611 04:23:40,607 --> 04:23:42,242 IMPORTANT ASPECTS OF THIS TRUST 7612 04:23:42,242 --> 04:23:44,878 DIMENSION. 7613 04:23:44,878 --> 04:23:46,613 AS I WAS LOOKING THROUGH THAT, 7614 04:23:46,613 --> 04:23:50,216 AND ALSO BEING VERY SORT OF 7615 04:23:50,216 --> 04:23:53,653 THOUGHTFULLY CONSIDERING WHAT 7616 04:23:53,653 --> 04:23:54,387 DR. BHATTACHARYA TOLD US TODAY 7617 04:23:54,387 --> 04:23:57,023 ABOUT THE BIG IDEAS IN DATA, I 7618 04:23:57,023 --> 04:23:58,525 WONDERED TO WHAT EXTENT THE 7619 04:23:58,525 --> 04:23:59,292 TRUST COMPONENTS NEED TO BE 7620 04:23:59,292 --> 04:24:02,028 THOUGHT OF AS SORT OF A 7621 04:24:02,028 --> 04:24:02,996 PUBLIC-PRIVATE PARTNERSHIP RIGHT 7622 04:24:02,996 --> 04:24:05,065 FROM THE VERY BEGINNING SO IN 7623 04:24:05,065 --> 04:24:07,400 FACT WE CAN GET INVOLVEMENT OF 7624 04:24:07,400 --> 04:24:08,401 STAKEHOLDERS WHO ARE LIKE LIKELY 7625 04:24:08,401 --> 04:24:09,903 TO HELP SCALE IN INDUSTRY AS 7626 04:24:09,903 --> 04:24:11,571 WELL AS IN ACADEMIA. 7627 04:24:11,571 --> 04:24:14,074 WITHOUT THAT, I WONDER WHETHER 7628 04:24:14,074 --> 04:24:15,408 EVEN THOUGH YOU'VE PUT A LOT OF 7629 04:24:15,408 --> 04:24:17,177 MONEY INTO THAT PARTICULAR SET 7630 04:24:17,177 --> 04:24:20,780 UP THREE PROGRAMS, I WONDER 7631 04:24:20,780 --> 04:24:21,748 WHETHER THAT'S EFFICIENT WITHOUT 7632 04:24:21,748 --> 04:24:22,649 HAVING SOMETHING THAT LOOKS MORE 7633 04:24:22,649 --> 04:24:24,150 LIKE A PUBLIC PRIVATE 7634 04:24:24,150 --> 04:24:24,918 PARTNERSHIP, ESPECIALLY GIVEN 7635 04:24:24,918 --> 04:24:28,655 THE WORK THAT'S GOING ON WITH AI 7636 04:24:28,655 --> 04:24:29,522 ASSURANCE LABS AND MANY OF THE 7637 04:24:29,522 --> 04:24:30,857 OTHER INITIATIVES, THEY'RE 7638 04:24:30,857 --> 04:24:31,725 INCLUDING SOME OF THE WORK THAT 7639 04:24:31,725 --> 04:24:34,160 THE FDA UNDER DR. CALIFF STARTED 7640 04:24:34,160 --> 04:24:36,763 THAT I'M SURE WILL CONTINUE. 7641 04:24:36,763 --> 04:24:38,498 I ALSO NOTE THERE ARE SOME 7642 04:24:38,498 --> 04:24:39,265 MULTIMODAL DATA NOT INCLUDED 7643 04:24:39,265 --> 04:24:40,467 THAT I WOULD PERSONALLY LOVE TO 7644 04:24:40,467 --> 04:24:41,868 SEE INCLUDED. 7645 04:24:41,868 --> 04:24:42,635 THERE'S VERY GOOD DATA NOW TO 7646 04:24:42,635 --> 04:24:44,504 SUGGEST THE USE OF UNSTRUCTURED 7647 04:24:44,504 --> 04:24:45,372 TEXT. 7648 04:24:45,372 --> 04:24:47,774 PERHAPS YOU INCLUDED IT BUT YOU 7649 04:24:47,774 --> 04:24:48,641 DIDN'T EXPLICITLY SAY IT. 7650 04:24:48,641 --> 04:24:49,843 I DIDN'T SEE ANYTHING ABOUT 7651 04:24:49,843 --> 04:24:51,378 AUDIO SIGNALS AND I DIDN'T SEE 7652 04:24:51,378 --> 04:24:52,512 ANYTHING ABOUT VIDEO. 7653 04:24:52,512 --> 04:24:54,347 AND I THINK ALL OF THOSE ARE NOT 7654 04:24:54,347 --> 04:24:56,316 YET EXPLICITLY MENTIONED BUT ALL 7655 04:24:56,316 --> 04:24:58,051 OF THEM ARE BEING ACTIVELY 7656 04:24:58,051 --> 04:25:01,254 FUNDED BOTH AT THE NSF AND AT 7657 04:25:01,254 --> 04:25:01,988 THE NIH. 7658 04:25:01,988 --> 04:25:03,523 THE BUDGET SEEMS APPROPRIATE FOR 7659 04:25:03,523 --> 04:25:04,090 THE MOST PART. 7660 04:25:04,090 --> 04:25:06,826 I'M CURIOUS HOW MODULAR SOFTWARE 7661 04:25:06,826 --> 04:25:09,562 TOOLS AND R03s WILL PROGRESS 7662 04:25:09,562 --> 04:25:11,598 TO R01 LEVEL FUNDING, AND IN 7663 04:25:11,598 --> 04:25:12,499 PARTICULAR, AGAIN THINKING ABOUT 7664 04:25:12,499 --> 04:25:15,201 THE CURRENT NIH DIRECTOR'S 7665 04:25:15,201 --> 04:25:16,069 STRATEGY, THESE ARE BIG IDEAS 7666 04:25:16,069 --> 04:25:17,370 AND I'M WONDERING WHETHER 7667 04:25:17,370 --> 04:25:18,238 THERE'S DIFFERENT MECHANISMS 7668 04:25:18,238 --> 04:25:20,774 THAT COULD BE USED, WHETHER IT 7669 04:25:20,774 --> 04:25:22,942 BE ONE OF THE UH MECHANISMS OR 7670 04:25:22,942 --> 04:25:24,611 OTHER MECHANISMS IN ADDITION TO 7671 04:25:24,611 --> 04:25:27,113 SMALL GRANTS AND R01s. 7672 04:25:27,113 --> 04:25:28,882 IS THERE AN EXPECTATION OF 7673 04:25:28,882 --> 04:25:30,850 INSTITUTES THAT WILL PICK UP THE 7674 04:25:30,850 --> 04:25:31,818 FUNDING REQUIREMENTS TO ENABLE 7675 04:25:31,818 --> 04:25:33,119 THESE PROJECTS TO GET ALL THE 7676 04:25:33,119 --> 04:25:34,754 WAY TO CLINICAL TRIAL? 7677 04:25:34,754 --> 04:25:36,956 IN OTHER WORDS, IF I GET AN R03, 7678 04:25:36,956 --> 04:25:38,158 IS THERE ANYTHING YOU GUYS CAN 7679 04:25:38,158 --> 04:25:40,693 DO TO HELP GUARANTEE THAT 7680 04:25:40,693 --> 04:25:41,795 SUCCESSFUL PROJECTS GET ALL THE 7681 04:25:41,795 --> 04:25:45,398 WAY TO TRIAL WITHOUT HAVING TO 7682 04:25:45,398 --> 04:25:46,499 CONSTANTLY RECOMPETE PER SOME OF 7683 04:25:46,499 --> 04:25:48,101 WHAT WE HEARD ABOUT THIS MORNING 7684 04:25:48,101 --> 04:25:49,202 THAT I THINK YOU'VE HEARD ABOUT, 7685 04:25:49,202 --> 04:25:51,604 OR IS THIS IDEA THAT MODULAR 7686 04:25:51,604 --> 04:25:52,839 SOFTWARE TOOLS TO ADDRESS 7687 04:25:52,839 --> 04:25:54,541 CRITICAL GAPS IN THE DATA TO 7688 04:25:54,541 --> 04:25:56,109 MODELS PIPELINE, THAT THIS WOULD 7689 04:25:56,109 --> 04:25:58,311 NOT DEVELOP TECHNOLOGIES THAT 7690 04:25:58,311 --> 04:26:00,180 WOULD BE USEFUL AT THE BEDSIDE. 7691 04:26:00,180 --> 04:26:01,247 I BELIEVE FROM WHAT YOU'VE 7692 04:26:01,247 --> 04:26:02,582 PRESENTED THAT YOUR HOPE IS THAT 7693 04:26:02,582 --> 04:26:03,983 THINGS GO FROM SORT OF 7694 04:26:03,983 --> 04:26:05,652 FOUNDATIONAL AND BASIC SCIENCE 7695 04:26:05,652 --> 04:26:07,287 ALL THE WAY TO TRIAL THROUGH 7696 04:26:07,287 --> 04:26:09,689 THIS SET OF MECHANISMS, AND IF 7697 04:26:09,689 --> 04:26:11,391 SO, I THINK IT WOULD BE GREAT TO 7698 04:26:11,391 --> 04:26:13,059 MAKE SURE THE CONCEPT KIND OF 7699 04:26:13,059 --> 04:26:16,429 HAS EXPLICIT LANGUAGE ABOUT SOME 7700 04:26:16,429 --> 04:26:18,098 OF THE WAYS IN WHICH THAT 7701 04:26:18,098 --> 04:26:22,035 TRANSITION COULD BE IMPROVED FOR 7702 04:26:22,035 --> 04:26:23,236 GROUPS WHO ARE FUNDED THROUGH 7703 04:26:23,236 --> 04:26:24,771 THIS MECHANISM. 7704 04:26:24,771 --> 04:26:27,273 THOSE ARE MY MAIN COMMENTS. 7705 04:26:27,273 --> 04:26:29,943 I APPLAUD YOU ON A BIG IDEA, I 7706 04:26:29,943 --> 04:26:31,578 APPLAUD YOU ON COMPREHENSIVE 7707 04:26:31,578 --> 04:26:32,912 THINKING, AND I'M VERY EXCITED 7708 04:26:32,912 --> 04:26:34,314 TO SEE WHAT COMES OUT OF THIS. 7709 04:26:34,314 --> 04:26:36,850 I'M GOING TO BE VERY SUPPORTIVE. 7710 04:26:36,850 --> 04:26:38,151 >> THANK YOU. 7711 04:26:38,151 --> 04:26:39,886 MIKE, MAYBE I COULD START OFF. 7712 04:26:39,886 --> 04:26:43,022 SO TALK ABOUT HIGH BIT RATE 7713 04:26:43,022 --> 04:26:45,658 INFORMATION CONTENT AND THAT WE 7714 04:26:45,658 --> 04:26:49,262 NEED TO CAPTURE THAT AUDIO AND 7715 04:26:49,262 --> 04:26:50,830 PARSE IT OUT THROUGH GENERATIVE 7716 04:26:50,830 --> 04:26:51,131 TECHNIQUES. 7717 04:26:51,131 --> 04:26:52,899 I THINK YOU HIT SO MANY OF THE 7718 04:26:52,899 --> 04:26:54,000 TOPICS THAT WE'VE BEEN 7719 04:26:54,000 --> 04:26:54,634 DISCUSSING. 7720 04:26:54,634 --> 04:26:57,504 MAYBE, MIKE, I'LL JUST JUMP IN 7721 04:26:57,504 --> 04:26:59,472 ON MIKE AND I AND THE ENTIRE 7722 04:26:59,472 --> 04:27:00,440 GROUP, WE'RE IMPATIENT. 7723 04:27:00,440 --> 04:27:03,076 WE SEE THE BEAUTIFUL BASIC 7724 04:27:03,076 --> 04:27:07,547 RESEARCH, SUPPORT IT, IT'S 7725 04:27:07,547 --> 04:27:09,315 INCREDIBLE AND INSPIRATIONAL, 7726 04:27:09,315 --> 04:27:12,819 BUT WE ARE ALSO FEELING THE GAP 7727 04:27:12,819 --> 04:27:14,020 BETWEEN THE ACTUAL CLINICAL 7728 04:27:14,020 --> 04:27:15,755 PRACTICE OF APPLYING ALL OF WHAT 7729 04:27:15,755 --> 04:27:17,724 WE ARE FINDING IN IMAGING 7730 04:27:17,724 --> 04:27:19,592 STUDIES ACROSS THE BOARD TO 7731 04:27:19,592 --> 04:27:22,862 MANAGEMENT OF PATIENTS. 7732 04:27:22,862 --> 04:27:25,064 AND WHAT WE'VE DONE IN NIBIB, SO 7733 04:27:25,064 --> 04:27:27,467 WE'RE BRINGING THE CULTURES OF 7734 04:27:27,467 --> 04:27:28,801 OUR INSTITUTES AND THE 7735 04:27:28,801 --> 04:27:29,903 SKILLSETS, SO I'LL JUST ADDRESS 7736 04:27:29,903 --> 04:27:32,172 A COUPLE OF THESE ISSUES WITH 7737 04:27:32,172 --> 04:27:36,442 RESPECT TO THE TOOLS THAT WE CAN 7738 04:27:36,442 --> 04:27:37,844 PROVIDE TO ACCELERATE THE 7739 04:27:37,844 --> 04:27:39,612 VALIDATION OF ALGORITHMS AND TO 7740 04:27:39,612 --> 04:27:41,781 MOVE THEM THROUGH THE REGULATORY 7741 04:27:41,781 --> 04:27:46,619 PROCESS AS QUICKLY AS POSSIBLE. 7742 04:27:46,619 --> 04:27:48,688 SO IN MANY OF THE PROGRAMS THAT 7743 04:27:48,688 --> 04:27:51,424 WE SUPPORT AT NIBIB, WE HAVE A 7744 04:27:51,424 --> 04:27:52,959 VERY STRONG TRACK RECORD WITH 7745 04:27:52,959 --> 04:27:53,960 ENGAGING FDA RIGHT AT THE 7746 04:27:53,960 --> 04:27:55,061 BEGINNING AND WE'RE DOING THIS 7747 04:27:55,061 --> 04:27:57,030 IN ONE OF OUR SORT OF PREMIER 7748 04:27:57,030 --> 04:27:58,898 IMAGING DATABASES, THE MEDICAL 7749 04:27:58,898 --> 04:28:00,867 IMAGING DATA RESOURCE CENTER OR 7750 04:28:00,867 --> 04:28:02,835 MIDRC, WHICH INTEGRATES, IT 7751 04:28:02,835 --> 04:28:04,370 STARTED IN COVID AND IT'S 7752 04:28:04,370 --> 04:28:08,908 PIVOTED TO CANCER, AND IT'S A 7753 04:28:08,908 --> 04:28:12,011 KIND OF EXEMPLAR OF HOW WE CAN 7754 04:28:12,011 --> 04:28:13,680 DEVELOP ALGORITHMS, VALIDATE 7755 04:28:13,680 --> 04:28:14,614 THEM AND MOVE THEM QUICKLY 7756 04:28:14,614 --> 04:28:17,817 THROUGH THE REGULATORY PROCESS. 7757 04:28:17,817 --> 04:28:20,787 IT ALSO HAS EXPLORED TO SOME 7758 04:28:20,787 --> 04:28:22,021 EXTENT THE FEDERATED LEARNING 7759 04:28:22,021 --> 04:28:24,824 AND REALLY WE HAVE BEEN TRYING 7760 04:28:24,824 --> 04:28:27,894 TO IDENTIFY THE KEY ADVANTAGES 7761 04:28:27,894 --> 04:28:29,662 TO WHEN THINGS ARE BETTER MOVED 7762 04:28:29,662 --> 04:28:31,598 THROUGH FEDERATED PROCESSES 7763 04:28:31,598 --> 04:28:32,899 VERSUS DATABASES, THEY EACH HAVE 7764 04:28:32,899 --> 04:28:34,000 THEIR OWN CHALLENGES, BUT I 7765 04:28:34,000 --> 04:28:35,768 THINK WE'RE IN A UNIQUE POSITION 7766 04:28:35,768 --> 04:28:39,339 AT THE NIH WHERE I THINK WE CAN 7767 04:28:39,339 --> 04:28:40,540 RECOGNIZE AND IDENTIFY THE 7768 04:28:40,540 --> 04:28:41,975 ADVANTAGES AND THE DISADVANTAGES 7769 04:28:41,975 --> 04:28:46,412 AND PROVIDE SUPPORTIVE RESOURCES 7770 04:28:46,412 --> 04:28:48,848 FOR THE VALIDATION PROCESS AND 7771 04:28:48,848 --> 04:28:50,383 DEPENDENT VALIDATION AND THEN 7772 04:28:50,383 --> 04:28:53,686 BRINGING REGULATORY INTO THIS 7773 04:28:53,686 --> 04:28:54,587 MIX AS EARLY AS POSSIBLE SO THAT 7774 04:28:54,587 --> 04:28:56,422 WE CAN GET SOFTWARE AS MEDICAL 7775 04:28:56,422 --> 04:28:58,291 DEVICES APPROVED AND DISTRIBUTED 7776 04:28:58,291 --> 04:29:02,595 IN VERY TRUSTWORTHY KINDS OF 7777 04:29:02,595 --> 04:29:02,996 PLATFORMS. 7778 04:29:02,996 --> 04:29:04,130 SO I'LL STOP THERE BECAUSE YOU 7779 04:29:04,130 --> 04:29:08,935 COVERED SO MANY TOPICS, BUT YES, 7780 04:29:08,935 --> 04:29:12,438 WE DO HAVE A WHOLE BUNCH ACROSS 7781 04:29:12,438 --> 04:29:15,074 OUR INSTITUTES OF ONGOING 7782 04:29:15,074 --> 04:29:18,611 ANCILLARY SUPPORT IN ADDITION TO 7783 04:29:18,611 --> 04:29:19,379 PARTNERING WITH ANCILLARY 7784 04:29:19,379 --> 04:29:20,446 STUDIES BEING SUPPORTED ACROSS 7785 04:29:20,446 --> 04:29:23,316 THE NIH AND EVEN IN THE INDUSTRY 7786 04:29:23,316 --> 04:29:26,286 COMMUNITY THAT WOULD DRIVE THESE 7787 04:29:26,286 --> 04:29:30,323 PUBLIC-PRIVATE PARTNERSHIPS, 7788 04:29:30,323 --> 04:29:31,858 WORKING WITH INDUSTRY, WORKING 7789 04:29:31,858 --> 04:29:33,493 WITH FDA, THIS IS SOMETHING 7790 04:29:33,493 --> 04:29:35,595 VERY, VERY NORMAL FOR US AND 7791 04:29:35,595 --> 04:29:36,562 SOMETHING WE'LL TAP INTO VERY, 7792 04:29:36,562 --> 04:29:37,997 VERY DEEPLY BECAUSE ALL THESE 7793 04:29:37,997 --> 04:29:39,666 TOOLS ARE SO FAST MOVING AND 7794 04:29:39,666 --> 04:29:40,867 THERE'S SUCH A HIGH DEMAND AND 7795 04:29:40,867 --> 04:29:43,069 EXPECTATION OF GROWTH. 7796 04:29:43,069 --> 04:29:43,836 > 7797 04:29:43,836 --> 04:29:44,570 >> THANK YOU. 7798 04:29:44,570 --> 04:29:46,072 I'M HAPPY TO SHARE MY NOTE, BY 7799 04:29:46,072 --> 04:29:46,472 THE WAY. 7800 04:29:46,472 --> 04:29:48,541 >> YOU KNOW, KEVIN, I'M ONLY 7801 04:29:48,541 --> 04:29:51,844 GOING TO SAY A COUPLE THINGS IN 7802 04:29:51,844 --> 04:29:54,580 FOLLOW-UP TO WHAT BRUCE SAID, 7803 04:29:54,580 --> 04:29:56,883 WHICH IS TOTALLY APPRECIATE YOUR 7804 04:29:56,883 --> 04:29:58,217 COMMENTS, EVERY SINGLE ONE I 7805 04:29:58,217 --> 04:30:01,821 THINK RESONATED WITH ME. 7806 04:30:01,821 --> 04:30:03,022 I THINK ONE OF THE THINGS THAT 7807 04:30:03,022 --> 04:30:05,558 WE REALLY TRIED TO LEAVE 7808 04:30:05,558 --> 04:30:10,163 FLEXIBILITY IN THIS PROJECT 7809 04:30:10,163 --> 04:30:13,433 DESIGN IS TO EVOLVE THE PROJECT 7810 04:30:13,433 --> 04:30:14,634 AS THE FIELD EVOLVES. 7811 04:30:14,634 --> 04:30:16,035 WE DIDN'T SHOW A GANTT CHART 7812 04:30:16,035 --> 04:30:17,203 ABOUT THE DIFFERENT ENTRY POINTS 7813 04:30:17,203 --> 04:30:20,106 OF PROJECTS, BUT I'M HOPING 7814 04:30:20,106 --> 04:30:21,641 THAT -- YOU MENTIONED A COMMENT 7815 04:30:21,641 --> 04:30:24,911 ABOUT FEDERATED LEARNING IN 7816 04:30:24,911 --> 04:30:25,912 PARTICULAR, AND I THINK THERE'S 7817 04:30:25,912 --> 04:30:27,013 A GOOD CHANCE THAT THE FIELD 7818 04:30:27,013 --> 04:30:28,314 WILL LOOK DIFFERENT IN 2027 7819 04:30:28,314 --> 04:30:29,482 COMPARED TO WHAT IT LOOKS LIKE 7820 04:30:29,482 --> 04:30:31,484 RIGHT NOW, AND I HOPE THAT'S 7821 04:30:31,484 --> 04:30:35,421 GOING TO BE ACCOUNTED FOR IN OUR 7822 04:30:35,421 --> 04:30:36,656 PROJECT DESIGN. 7823 04:30:36,656 --> 04:30:39,359 KEVIN, YOU MENTIONED SOMETHING 7824 04:30:39,359 --> 04:30:41,227 ABOUT MULTIMODAL DATA AND THINGS 7825 04:30:41,227 --> 04:30:44,297 LIKE UNSTRUCTURED TEXT AND 7826 04:30:44,297 --> 04:30:46,165 VIDEO, AND I COMPLETELY AGREE. 7827 04:30:46,165 --> 04:30:47,600 YOU KNOW, JUST ON A PERSONAL 7828 04:30:47,600 --> 04:30:49,235 LEVEL, YOU AND I HAD A GREAT 7829 04:30:49,235 --> 04:30:51,871 CONVERSATION WHEN I WAS IN 7830 04:30:51,871 --> 04:30:53,840 PHILADELPHIA ABOUT A YEAR AGO, 7831 04:30:53,840 --> 04:30:54,507 SOME OF THE STUFF YOU'RE DOING 7832 04:30:54,507 --> 04:30:55,708 WITH THAT, AND I THINK THAT 7833 04:30:55,708 --> 04:30:58,444 THERE COULD BE A LOT OF -- I 7834 04:30:58,444 --> 04:30:59,679 AGREE I DON'T THINK THE ONLY 7835 04:30:59,679 --> 04:31:02,715 FORM OF DATA IS A DOCTOR OR 7836 04:31:02,715 --> 04:31:05,685 NURSE, YOU KNOW, CHECKING A 7837 04:31:05,685 --> 04:31:07,887 CHECK BOX OR USING A SO CALLED 7838 04:31:07,887 --> 04:31:09,422 DOT PHRASE, SO THAT WOULD BE 7839 04:31:09,422 --> 04:31:12,024 FABULOUS FOR SO MANY REASONS. 7840 04:31:12,024 --> 04:31:14,927 AND THERE ARE MANY THINGS THAT 7841 04:31:14,927 --> 04:31:18,831 I'VE PERSONALLY LEARNED FROM 7842 04:31:18,831 --> 04:31:20,700 BRIDGE2AI, BETTER WAYS TO DO 7843 04:31:20,700 --> 04:31:22,769 TEAMING, THE IMPORTANCE OF DATA, 7844 04:31:22,769 --> 04:31:24,337 THE IMPORTANCE OF STANDARDS AND 7845 04:31:24,337 --> 04:31:26,839 HOW EVERYBODY LIKES STANDARDS AS 7846 04:31:26,839 --> 04:31:28,374 LONG AS THEY'RE MY STANDARDS, 7847 04:31:28,374 --> 04:31:31,043 AND NOT USING SOMEBODY ELSE'S, 7848 04:31:31,043 --> 04:31:35,081 BUT ONE OF THE OTHER -- I 7849 04:31:35,081 --> 04:31:36,349 COMPLETELY AGREE WITH WHAT YOU 7850 04:31:36,349 --> 04:31:38,418 SAID ABOUT PUBLIC-PRIVATE 7851 04:31:38,418 --> 04:31:40,720 PARTNERSHIPS AND THAT'S THE 7852 04:31:40,720 --> 04:31:43,656 SPIRIT OF THESE, BUT AS BRUCE 7853 04:31:43,656 --> 04:31:45,258 SAID MAYBE WE NEED TO DO MORE 7854 04:31:45,258 --> 04:31:46,759 WITH ENGAGING FDA OR THE PAYORS 7855 04:31:46,759 --> 04:31:50,096 UP FRONT ABOUT THIS, BUT 7856 04:31:50,096 --> 04:31:50,696 ULTIMATELY ONE OF THE THINGS 7857 04:31:50,696 --> 04:31:52,498 THAT I PERSONALLY LEARNED WAS 7858 04:31:52,498 --> 04:31:54,801 THAT BRIDGE2AI IS NOT ENOUGH TO 7859 04:31:54,801 --> 04:31:56,135 ENHANCE THE FIELD. 7860 04:31:56,135 --> 04:31:57,870 SO HENCE WHY WE'RE HERE. 7861 04:31:57,870 --> 04:31:59,439 SO THANK YOU FOR ALL OF THAT, 7862 04:31:59,439 --> 04:32:01,641 AND I'LL STOP. 7863 04:32:01,641 --> 04:32:02,275 >> THANK YOU. 7864 04:32:02,275 --> 04:32:05,077 >> MIKE, IF I COULD JUST DO TWO 7865 04:32:05,077 --> 04:32:08,147 QUICK ADD-ONS TO THAT. 7866 04:32:08,147 --> 04:32:09,615 BRIDGE2AI, KEVIN YOU MENTIONED 7867 04:32:09,615 --> 04:32:10,783 THE AUDIO DATA WHICH WE'RE SO 7868 04:32:10,783 --> 04:32:13,419 EXCITED ABOUT AND IN FACT THAT 7869 04:32:13,419 --> 04:32:15,054 COULD BE MOST BEAUTIFUL STANDARD 7870 04:32:15,054 --> 04:32:16,556 AND EASILY ACCESSIBLE STANDARD 7871 04:32:16,556 --> 04:32:18,758 DATA FORMATS TO BE ABLE TO 7872 04:32:18,758 --> 04:32:20,493 INTEGRATE INTO THIS, WE'RE 7873 04:32:20,493 --> 04:32:22,462 CERTAINLY EXPECTING BIG THINGS 7874 04:32:22,462 --> 04:32:24,997 FROM THAT PROGRAM IN BRIDGE2AI. 7875 04:32:24,997 --> 04:32:29,368 IN TERMS OF THE R03 MECHANISM, 7876 04:32:29,368 --> 04:32:30,937 THIS IS A REALLY ONGOING 7877 04:32:30,937 --> 04:32:31,704 DISCUSSION AND DEBATE AMONGST 7878 04:32:31,704 --> 04:32:34,307 US. 7879 04:32:34,307 --> 04:32:35,708 R03, EVEN THOUGH IT'S A LOWER 7880 04:32:35,708 --> 04:32:37,810 BARRIER TO ENTRY, IS NOT 7881 04:32:37,810 --> 04:32:39,212 NECESSARILY A FAST TURNAROUND 7882 04:32:39,212 --> 04:32:40,112 TIME MECHANISM. 7883 04:32:40,112 --> 04:32:43,483 SO WE'RE EXPLORING APPROACHES 7884 04:32:43,483 --> 04:32:45,551 THAT WE PIONEERED IN NIBIB 7885 04:32:45,551 --> 04:32:48,454 THROUGH THE RAPID ACCELERATION 7886 04:32:48,454 --> 04:32:51,257 OF DIAGNOSTICS TECHNOLOGIES 7887 04:32:51,257 --> 04:32:54,327 PROGRAM, AND MIKE HAD MENTIONED 7888 04:32:54,327 --> 04:32:55,862 THE INNOVATION FUNNEL IN HIS 7889 04:32:55,862 --> 04:32:59,565 PRESENTATION PART, AND SO WE ARE 7890 04:32:59,565 --> 04:33:01,000 ABSOLUTELY CONSIDERING THAT AS A 7891 04:33:01,000 --> 04:33:04,537 WAY TO GET FUNDING TO DEVELOPERS 7892 04:33:04,537 --> 04:33:08,140 VERY, VERY QUICKLY, IN 7893 04:33:08,140 --> 04:33:08,708 UNPRECEDENTED TIME FRAMES, A 7894 04:33:08,708 --> 04:33:10,209 MATTER OF WEEKS, BUT ALSO BUILD 7895 04:33:10,209 --> 04:33:13,079 TEAMS AROUND THEM TO OPTIMIZE 7896 04:33:13,079 --> 04:33:15,381 THE CONCEPTS THAT ARE PROPOSED 7897 04:33:15,381 --> 04:33:17,650 AND PROVIDE THEM WITH ADDITIONAL 7898 04:33:17,650 --> 04:33:18,985 RESOURCES FOR DOING BETTER WITH 7899 04:33:18,985 --> 04:33:21,654 THE TECHNOLOGY, MOVING TO 7900 04:33:21,654 --> 04:33:22,522 MARKETS POTENTIALLY IF IT'S 7901 04:33:22,522 --> 04:33:23,956 BEING COMMERCIALIZED, AND 7902 04:33:23,956 --> 04:33:25,591 PARTNERING WITH THE FDA. 7903 04:33:25,591 --> 04:33:27,393 SO THESE ARE ALL TOPICS THAT WE 7904 04:33:27,393 --> 04:33:29,328 FEEL WE CAN DRAW ON BECAUSE OF 7905 04:33:29,328 --> 04:33:31,163 OUR COLLECTIVE EXPERIENCES 7906 04:33:31,163 --> 04:33:34,500 ACROSS THIS AMAZING GROUP OF 19 7907 04:33:34,500 --> 04:33:35,601 DIFFERENT INSTITUTES, CENTERS 7908 04:33:35,601 --> 04:33:36,903 AND OFFICES. 7909 04:33:36,903 --> 04:33:37,336 THANK YOU. 7910 04:33:37,336 --> 04:33:38,671 >> THANKS. 7911 04:33:38,671 --> 04:33:40,506 I THINK -- WELL, I'M THE OTHER 7912 04:33:40,506 --> 04:33:42,008 DISCUSSANT, SO DO YOU WANT ME TO 7913 04:33:42,008 --> 04:33:43,242 MENTION A FEW THINGS? 7914 04:33:43,242 --> 04:33:44,911 >> PERFECT, YES, THANK YOU, 7915 04:33:44,911 --> 04:33:45,111 LINDA. 7916 04:33:45,111 --> 04:33:46,145 I WAS JUST ABOUT TO CALL ON YOU. 7917 04:33:46,145 --> 04:33:47,013 >> OKAY. 7918 04:33:47,013 --> 04:33:49,982 ALL RIGHT. 7919 04:33:49,982 --> 04:33:51,517 WELL, THANK YOU AGAIN FOR THIS 7920 04:33:51,517 --> 04:33:53,719 PRESENTATION AND YOU GUYS, 7921 04:33:53,719 --> 04:33:55,254 DR. CHIANG AND DR. TROMBERG, YOU 7922 04:33:55,254 --> 04:33:57,990 GUYS AND YOUR TEAM OF 50 PEOPLE 7923 04:33:57,990 --> 04:33:59,959 HAVE DONE AN AMAZING JOB OF, YOU 7924 04:33:59,959 --> 04:34:03,462 KNOW, DELINEATING SOME OF THE 7925 04:34:03,462 --> 04:34:04,263 DIFFERENT POINTS AND THE THINGS 7926 04:34:04,263 --> 04:34:05,464 FOR THIS CONCEPT. 7927 04:34:05,464 --> 04:34:06,666 I THINK IT'S A GREAT CONCEPT 7928 04:34:06,666 --> 04:34:08,301 OVERALL, AND I AGREE WITH 7929 04:34:08,301 --> 04:34:11,904 EVERYTHING THAT KEVIN MENTIONED 7930 04:34:11,904 --> 04:34:13,573 ALREADY TOO SO I'M NOT GOING TO 7931 04:34:13,573 --> 04:34:14,040 REITERATE THOSE. 7932 04:34:14,040 --> 04:34:17,944 SO I'M JUST GOING TO MENTION A 7933 04:34:17,944 --> 04:34:20,613 COUPLE PROBLEMS THAT I SEE WITH 7934 04:34:20,613 --> 04:34:21,948 FEASIBILITY AND I'M SURE YOU'VE 7935 04:34:21,948 --> 04:34:22,915 THOUGHT ABOUT THEM AND YOU 7936 04:34:22,915 --> 04:34:24,584 STARTED TO TALK ABOUT SOME OF 7937 04:34:24,584 --> 04:34:25,117 THEM ALREADY. 7938 04:34:25,117 --> 04:34:27,553 AND ALSO I THOUGHT WHAT YOU ARE 7939 04:34:27,553 --> 04:34:28,955 PROPOSING IS ACTUALLY SO SIMILAR 7940 04:34:28,955 --> 04:34:31,157 TO WHAT THE NEW NIH DIRECTOR 7941 04:34:31,157 --> 04:34:31,691 JUST PRESENTED. 7942 04:34:31,691 --> 04:34:33,459 DID YOU SEE THIS MORNING? 7943 04:34:33,459 --> 04:34:34,760 HE HAS THIS REAL WORLD DATA 7944 04:34:34,760 --> 04:34:36,529 PLATFORM THAT HE MENTIONED. 7945 04:34:36,529 --> 04:34:39,098 IT'S LIKE THE SAME THING AS WHAT 7946 04:34:39,098 --> 04:34:40,066 YOU'RE TRYING TO DO, EXCEPT I 7947 04:34:40,066 --> 04:34:42,702 DON'T KNOW IF HE MEANT TO APPLY 7948 04:34:42,702 --> 04:34:46,639 THAT JUST TO AUTISM OR TO ANY 7949 04:34:46,639 --> 04:34:46,872 DISEASE. 7950 04:34:46,872 --> 04:34:47,907 YOU SHOULD GO BACK AND LOOK AT 7951 04:34:47,907 --> 04:34:48,674 THAT SLIDE. 7952 04:34:48,674 --> 04:34:50,309 IT LOOKS EXACTLY THE SAME AS 7953 04:34:50,309 --> 04:34:52,078 WHAT YOU'RE PLANNING TO DO, AND 7954 04:34:52,078 --> 04:34:52,912 MAYBE YOU CAN TEAM UP WITH HIM 7955 04:34:52,912 --> 04:34:55,815 AND GET MORE FUNDING FOR THIS. 7956 04:34:55,815 --> 04:34:57,950 ANYWAY, SO MY TWO AREAS THAT I 7957 04:34:57,950 --> 04:35:01,120 WANT TO BRING UP REGARDING 7958 04:35:01,120 --> 04:35:03,956 POSSIBLE FEASIBILITY ISSUE, THE 7959 04:35:03,956 --> 04:35:06,092 FIRST ONE HAS TO DO WITH THE 7960 04:35:06,092 --> 04:35:06,492 INPUT DATA. 7961 04:35:06,492 --> 04:35:07,793 SO YOU ALREADY SAW FROM THE 7962 04:35:07,793 --> 04:35:11,764 EXECUTIVE SUMMARY FROM YOUR RFI 7963 04:35:11,764 --> 04:35:14,500 THAT THE FIRST ITEM THEY 7964 04:35:14,500 --> 04:35:18,004 EMPHASIZE DATA INTEGRATION AND 7965 04:35:18,004 --> 04:35:19,105 ADJUSTING -- DATA HARMONIZATION 7966 04:35:19,105 --> 04:35:20,339 BECAUSE I CAN TELL YOU I'M 7967 04:35:20,339 --> 04:35:24,377 INVOLVED IN THIS BIG MULTICENTER 7968 04:35:24,377 --> 04:35:26,012 STUDY, 21 SITES FOR THE ABCD 7969 04:35:26,012 --> 04:35:27,813 STUDY AND WE HAVE LIKE THE SAME 7970 04:35:27,813 --> 04:35:30,983 PROTOCOL THAT'S IDENTICAL, THREE 7971 04:35:30,983 --> 04:35:33,085 TESLA SCAN ACROSS ALL THE SITES 7972 04:35:33,085 --> 04:35:35,721 AND THE SAME ALREADY OPTIMIZED 7973 04:35:35,721 --> 04:35:36,922 IMAGING PROTOCOL BUT WE HAVE 7974 04:35:36,922 --> 04:35:38,557 DIFFERENT VENDORS LIKE GE AND 7975 04:35:38,557 --> 04:35:41,460 PHILLIPS AND SIEMENS, AND EVEN 7976 04:35:41,460 --> 04:35:44,063 WITH THAT, IT'S SO HARD TO 7977 04:35:44,063 --> 04:35:45,164 HARMONIZE WHEN WE END UP HAVING 7978 04:35:45,164 --> 04:35:47,700 TO THROW OUT DATA IN ORDER TO 7979 04:35:47,700 --> 04:35:48,934 GET REASONABLE RESULTS TO 7980 04:35:48,934 --> 04:35:49,902 MINIMIZE THE VARIABILITY, SO 7981 04:35:49,902 --> 04:35:50,803 YOU'RE GOING TO BE -- IF YOU'RE 7982 04:35:50,803 --> 04:35:53,205 GOING TO BE WORKING WITH 7983 04:35:53,205 --> 04:35:57,143 CLINICAL DATA FROM EVERYWHERE, 7984 04:35:57,143 --> 04:35:59,679 YOU'RE GOING TO GET EHR, 7985 04:35:59,679 --> 04:36:00,546 ELECTRONIC HEALTH RECORD FROM 7986 04:36:00,546 --> 04:36:01,981 DIFFERENT HOSPITALS, FROM 7987 04:36:01,981 --> 04:36:03,015 DIFFERENT CLINICIANS, 7988 04:36:03,015 --> 04:36:03,883 EVERYBODY -- YOU JUST MENTIONED 7989 04:36:03,883 --> 04:36:09,689 THIS EARLIER, EVERYBODY CHARTS 7990 04:36:09,689 --> 04:36:11,123 THINGS DIFFERENTLY, ARE THEY 7991 04:36:11,123 --> 04:36:12,992 GOING TO ENTER UNIFORMLY KIND OF 7992 04:36:12,992 --> 04:36:14,126 LIKE THE WAY WE DO DATA 7993 04:36:14,126 --> 04:36:15,661 COLLECTION WITH THE SCIENTIFIC 7994 04:36:15,661 --> 04:36:16,362 PROTOCOL, THAT WOULD CERTAINLY 7995 04:36:16,362 --> 04:36:18,330 HELP MAYBE, I DON'T KNOW, BUT IT 7996 04:36:18,330 --> 04:36:19,331 JUST SEEMS LIKE IN ORDER FOR 7997 04:36:19,331 --> 04:36:21,734 THIS TO WORK, YOU WILL NEED 7998 04:36:21,734 --> 04:36:24,537 BILLIONS OF TRAINING DATASETS, 7999 04:36:24,537 --> 04:36:26,072 LIKE THE WAY CHATGPT WAS 8000 04:36:26,072 --> 04:36:29,542 DEVELOPED WITH BILLIONS OF 8001 04:36:29,542 --> 04:36:31,711 WEBSITES USED SO I'M JUST NOT 8002 04:36:31,711 --> 04:36:35,314 SURE ANY ONE OR TWO SITES, ONE 8003 04:36:35,314 --> 04:36:36,549 OR TWO INSTITUTIONS CAN ACTUALLY 8004 04:36:36,549 --> 04:36:39,418 ACHIEVE THIS GOAL, AND IN SOME 8005 04:36:39,418 --> 04:36:43,689 SENSE, DEVELOPING ALGORITHM TO 8006 04:36:43,689 --> 04:36:44,790 DEFINE THE DATASET YOU 8007 04:36:44,790 --> 04:36:46,726 MENTIONED, THE FUNNELING OR 8008 04:36:46,726 --> 04:36:47,893 WHATEVER, TO IMPROVE MEDICAL OUT 8009 04:36:47,893 --> 04:36:50,096 COME, IT'S A VERY -- IT'S LIKE 8010 04:36:50,096 --> 04:36:51,330 AN APPLIED PROJECT BECAUSE I 8011 04:36:51,330 --> 04:36:54,900 THINK A LOT OF ALGORITHMS ARE 8012 04:36:54,900 --> 04:36:57,169 ALREADY AVAILABLE. 8013 04:36:57,169 --> 04:36:59,004 YOU SAW EVEN WITH YOUR NIH AWARD 8014 04:36:59,004 --> 04:37:01,540 THAT THERE ARE MANY, MANY PEOPLE 8015 04:37:01,540 --> 04:37:02,208 DEVELOPING ALGORITHMS BUT THEY 8016 04:37:02,208 --> 04:37:03,509 JUST DON'T APPLY THEM, RIGHT? 8017 04:37:03,509 --> 04:37:04,810 SO YOU NEED TO BRING IT 8018 04:37:04,810 --> 04:37:05,478 TOGETHER. 8019 04:37:05,478 --> 04:37:07,046 SO IT'S JUST FINDING THE DATA 8020 04:37:07,046 --> 04:37:08,781 WOULD BE VERY DIFFICULT, SO 8021 04:37:08,781 --> 04:37:10,216 THAT'S MY FIRST POINT. 8022 04:37:10,216 --> 04:37:13,185 AND THEN THE SECOND POINT IS I 8023 04:37:13,185 --> 04:37:13,986 THINK YOU HAVE VERY LIMITED 8024 04:37:13,986 --> 04:37:14,620 BUDGET. 8025 04:37:14,620 --> 04:37:16,355 I KNOW KEVIN MENTIONED THE 8026 04:37:16,355 --> 04:37:17,890 BUDGET IS APPROPRIATE, BUT IF 8027 04:37:17,890 --> 04:37:19,825 YOU GO ONLINE AND JUST LOOK AT 8028 04:37:19,825 --> 04:37:24,296 HOW MUCH IT COSTS FOR OPEN AI OR 8029 04:37:24,296 --> 04:37:28,467 AI DEVELOPMENT IN THE PRIVATE 8030 04:37:28,467 --> 04:37:30,336 VENTURE FUNDS, I THINK THEY 8031 04:37:30,336 --> 04:37:31,771 INVEST OVER A HUNDRED BILLION 8032 04:37:31,771 --> 04:37:33,939 DOLLARS PER YEAR, I THINK IN 8033 04:37:33,939 --> 04:37:36,742 2024, THEY SAID THEY INVESTED 8034 04:37:36,742 --> 04:37:38,778 $110 BILLION A YEAR TO DEVELOP 8035 04:37:38,778 --> 04:37:40,346 AI TOOLS, AND I CAN TELL YOU 8036 04:37:40,346 --> 04:37:44,550 MOST OF THEM ARE ACTUALLY FOR 8037 04:37:44,550 --> 04:37:45,117 MEDICAL APPLICATIONS. 8038 04:37:45,117 --> 04:37:46,552 SO IT LOOKS LIKE THE PRIVATE 8039 04:37:46,552 --> 04:37:48,654 MONEY IS OUTSPENDING NIH BY 8040 04:37:48,654 --> 04:37:49,655 ORDERS OF MAGNITUDE, SO I THINK 8041 04:37:49,655 --> 04:37:52,391 YOU NEED A LOT MORE MONEY TO 8042 04:37:52,391 --> 04:37:54,994 MAKE THIS TO WORK. 8043 04:37:54,994 --> 04:37:59,031 I LOOKED UP ABOUT -- I THINK 8044 04:37:59,031 --> 04:38:03,969 FDA-APPROVED A LOT OF -- 900AI 8045 04:38:03,969 --> 04:38:05,771 MACHINE LEARNING ENABLED MEDICAL 8046 04:38:05,771 --> 04:38:08,274 DEVICES LAST YEAR ALONE, SO 8047 04:38:08,274 --> 04:38:10,109 THOSE WILL CONTINUE TO RAMP UP, 8048 04:38:10,109 --> 04:38:12,244 SO GLOBAL AI IN HEALTHCARE 8049 04:38:12,244 --> 04:38:15,414 MARKET IS PROJECTED TO REACH 8050 04:38:15,414 --> 04:38:19,285 $164 BILLION BY 2030. 8051 04:38:19,285 --> 04:38:20,886 SO I THINK YOU WOULD NEED MORE 8052 04:38:20,886 --> 04:38:21,086 MONEY. 8053 04:38:21,086 --> 04:38:23,055 THE FINAL POINT ABOUT NEEDING 8054 04:38:23,055 --> 04:38:24,390 MORE MONEY HAS TO DO WITH 8055 04:38:24,390 --> 04:38:26,792 INFRASTRUCTURE BECAUSE IN ORDER 8056 04:38:26,792 --> 04:38:29,595 TO MAINTAIN -- YOU NEED A LOT OF 8057 04:38:29,595 --> 04:38:31,764 COMPUTING POWER, LIKE FOR 8058 04:38:31,764 --> 04:38:33,399 INSTANCE, CHATGPT COSTS 8059 04:38:33,399 --> 04:38:36,836 SOMETHING LIKE OPEN AI, THEY 8060 04:38:36,836 --> 04:38:39,138 SPEND $700,000 A DAY TO RUN 8061 04:38:39,138 --> 04:38:41,340 CHATGPT AND I TALKED TO SOME OF 8062 04:38:41,340 --> 04:38:42,575 MY COLLEAGUES THAT ARE DOING AI 8063 04:38:42,575 --> 04:38:44,410 RESEARCH IN RADIOLOGY, AND THEY 8064 04:38:44,410 --> 04:38:47,746 SAID THAT A LOT OF PEOPLE IN 8065 04:38:47,746 --> 04:38:49,949 ACADEMIA HAVE A REALLY HARD 8066 04:38:49,949 --> 04:38:51,684 TIME, SO IF NIH CAN PROVIDE SOME 8067 04:38:51,684 --> 04:38:55,187 KIND OF COMPUTING INFRASTRUCTURE 8068 04:38:55,187 --> 04:38:57,623 TO ENABLE THE SCIENTISTS, LIKE 8069 04:38:57,623 --> 04:38:58,858 SOME SORT OF OPEN COMPUTING 8070 04:38:58,858 --> 04:39:00,593 RESOURCE THAT ALLOW RESEARCHERS 8071 04:39:00,593 --> 04:39:03,195 TO TRY EVEN MIDDLE SIZED 8072 04:39:03,195 --> 04:39:05,698 NETWORKS, SO EVEN THE SMALLEST 8073 04:39:05,698 --> 04:39:06,932 LLM NETWORK IS CHALLENGING FOR 8074 04:39:06,932 --> 04:39:09,501 MOST OF THE RESEARCHERS IN 8075 04:39:09,501 --> 04:39:10,836 ACADEMIA, SO THOSE ARE MY 8076 04:39:10,836 --> 04:39:11,370 POINTS. 8077 04:39:11,370 --> 04:39:13,772 I JUST THINK IT MIGHT HELP WITH 8078 04:39:13,772 --> 04:39:15,841 WHAT YOU WANT TO DO, BUT YOU 8079 04:39:15,841 --> 04:39:17,276 SHOULD ASK FOR MONONUCLEOSIS EE, 8080 04:39:17,276 --> 04:39:20,012 I THINK. 8081 04:39:20,012 --> 04:39:20,112 MON 8082 04:39:23,916 --> 04:39:25,517 -- FOR MORE 8083 04:39:25,517 --> 04:39:25,718 MONEY. 8084 04:39:25,718 --> 04:39:27,686 >> I'LL START HERE AND SAY THANK 8085 04:39:27,686 --> 04:39:28,787 YOU FOR MAKING THOSE THREE 8086 04:39:28,787 --> 04:39:29,188 THINGS. 8087 04:39:29,188 --> 04:39:30,723 TO ME, IT SEEMED LIKE YOU MADE 8088 04:39:30,723 --> 04:39:31,257 THREE POINTS. 8089 04:39:31,257 --> 04:39:35,327 TWO OF THEM, INPUT DATA, GARBAGE 8090 04:39:35,327 --> 04:39:37,563 IN, GARBAGE OUT, AND WE NEED TO 8091 04:39:37,563 --> 04:39:40,532 STANDARDIZE DATA, TOTALLY AGREE. 8092 04:39:40,532 --> 04:39:42,234 PERHAPS ONE OF THE APPROACHES 8093 04:39:42,234 --> 04:39:43,569 WE'LL TAKE IS DEVELOPING AI 8094 04:39:43,569 --> 04:39:49,241 METHODS TO HELP WITH TA STAN 8095 04:39:49,241 --> 04:39:50,542 STANDARDIZATION AND 8096 04:39:50,542 --> 04:39:51,176 METHODIZATION. 8097 04:39:51,176 --> 04:39:51,944 COMPUTING POWER, WE'VE 8098 04:39:51,944 --> 04:39:52,945 DEFINITELY TALKED ABOUT THIS. 8099 04:39:52,945 --> 04:39:55,915 THERE'S AN ADVISOR THAT THE NIH 8100 04:39:55,915 --> 04:39:59,084 COUNCIL, THE ACD, HAS A WORKING 8101 04:39:59,084 --> 04:40:00,185 GROUP ON AI. 8102 04:40:00,185 --> 04:40:04,290 BOTH BRUCE AND I SPOKE TO THAT, 8103 04:40:04,290 --> 04:40:05,591 AND THAT TOPIC CAME UP IN 8104 04:40:05,591 --> 04:40:06,025 DISCUSSIONS. 8105 04:40:06,025 --> 04:40:08,327 SO TOTALLY AGREE, TOTALLY AGREE. 8106 04:40:08,327 --> 04:40:09,561 YOUR THIRD COMMENT ABOUT BUDGET, 8107 04:40:09,561 --> 04:40:12,331 I'M NOT PERMITTED TO OPINE ON AS 8108 04:40:12,331 --> 04:40:14,466 A GOVERNMENT EMPLOYEE, SO I WILL 8109 04:40:14,466 --> 04:40:15,668 JUST THANK YOU FOR MAKING THAT 8110 04:40:15,668 --> 04:40:15,901 COMMENT. 8111 04:40:15,901 --> 04:40:17,303 >> I WAS JUST LOOKING AT HOW 8112 04:40:17,303 --> 04:40:18,470 MUCH INDUSTRY IS SPENDING, WHAT 8113 04:40:18,470 --> 04:40:20,072 YOU'RE TRYING TO DO IS LIKE A 8114 04:40:20,072 --> 04:40:20,839 DROP IN THE BUCKET COMPARED TO 8115 04:40:20,839 --> 04:40:22,641 WHAT THEY ARE DOING, SO IT LIKE, 8116 04:40:22,641 --> 04:40:23,876 I KNOW YOU HAVE TO START 8117 04:40:23,876 --> 04:40:25,344 SOMEWHERE, AND ALSO FOCUSING ON 8118 04:40:25,344 --> 04:40:26,312 IMAGING IS REALLY GREAT. 8119 04:40:26,312 --> 04:40:29,515 I DO IMAGING RESEARCH SO I 8120 04:40:29,515 --> 04:40:30,749 REALLY SUPPORT THAT, BUT I JUST 8121 04:40:30,749 --> 04:40:32,818 FEEL LIKE HOW MUCH CAN YOU DO 8122 04:40:32,818 --> 04:40:34,019 COMPARED TO WHAT THE REST OF THE 8123 04:40:34,019 --> 04:40:37,356 WORLD IS DOING. 8124 04:40:37,356 --> 04:40:38,390 >> IF I MAY JUST JUMP IN QUICKLY 8125 04:40:38,390 --> 04:40:38,691 HERE. 8126 04:40:38,691 --> 04:40:42,795 I JUST WANT TO HIGHLIGHT, RI LI, 8127 04:40:42,795 --> 04:40:43,429 ONE OF THE COMMENTS THAT YOU 8128 04:40:43,429 --> 04:40:46,265 MADE ACTUALLY I THINK IS REALLY 8129 04:40:46,265 --> 04:40:48,701 ESSENTIAL TO UNDERSTAND THAT 8130 04:40:48,701 --> 04:40:51,904 THIS IS -- WELL, THIS IS A 8131 04:40:51,904 --> 04:40:53,539 REALLY FANTASTIC CONCEPT IN AND 8132 04:40:53,539 --> 04:40:56,041 OF ITSELF AS A STANDALONE 8133 04:40:56,041 --> 04:40:56,909 PROGRAM, INHERENTLY IT'S NOT 8134 04:40:56,909 --> 04:40:58,544 GOING TO FUNCTION IN A VACUUM OR 8135 04:40:58,544 --> 04:41:02,247 IN A SILO. 8136 04:41:02,247 --> 04:41:03,882 SO YOU HIGHLIGHTED A 8137 04:41:03,882 --> 04:41:04,383 PRESENTATION THAT 8138 04:41:04,383 --> 04:41:05,050 DR. BHATTACHARYA MADE THIS 8139 04:41:05,050 --> 04:41:06,452 MORNING AND HIS REMARKS ABOUT 8140 04:41:06,452 --> 04:41:11,490 THIS REAL WORLD DATA PLATFORM. 8141 04:41:11,490 --> 04:41:13,292 SO WE FULLY EXPECT THAT PRIMED 8142 04:41:13,292 --> 04:41:14,693 AI WILL BE ONE OF THE DATA 8143 04:41:14,693 --> 04:41:16,895 SOURCES AND ONE OF THE PLATFORMS 8144 04:41:16,895 --> 04:41:18,931 THAT BECOME INTEGRATED THROUGH 8145 04:41:18,931 --> 04:41:21,000 THAT REAL WORLD DATA PLATFORM. 8146 04:41:21,000 --> 04:41:23,969 JUST LIKE THE NCATS N3C OR THE 8147 04:41:23,969 --> 04:41:27,272 NIA LINKAGE OR THE NCIC -- THERE 8148 04:41:27,272 --> 04:41:31,210 ARE SO MANY EXISTING EFFORTS AND 8149 04:41:31,210 --> 04:41:33,746 DATA INFRASTRUCTURES ACROSS THE 8150 04:41:33,746 --> 04:41:35,614 NIH THAT DESERVE TO COMMUNICATE 8151 04:41:35,614 --> 04:41:37,916 AND TALK TO ONE ANOTHER, AND BE 8152 04:41:37,916 --> 04:41:42,187 JOINED WITH OTHER REAL WORLD 8153 04:41:42,187 --> 04:41:44,323 DATASETS SUCH AS THOSE 8154 04:41:44,323 --> 04:41:44,957 DR. BHATTACHARYA MENTIONED THAT 8155 04:41:44,957 --> 04:41:46,725 WE ARE IN DISCUSSIONS WITH OUR 8156 04:41:46,725 --> 04:41:47,693 FEDERAL PARTNERS ACROSS THE 8157 04:41:47,693 --> 04:41:49,395 GOVERNMENT TO ACCESS IN A SECURE 8158 04:41:49,395 --> 04:41:49,728 FASHION. 8159 04:41:49,728 --> 04:41:53,332 AND SO I THINK THAT THAT WILL 8160 04:41:53,332 --> 04:42:00,105 PROBABLY PROVIDE SOME OF THE 8161 04:42:00,105 --> 04:42:01,373 INFRASTRUCTURE BOTH FROM THE 8162 04:42:01,373 --> 04:42:02,374 STORAGE AND THE COMPUTE SIDE 8163 04:42:02,374 --> 04:42:04,643 THAT YOU'RE A LITTLE CONCERNED 8164 04:42:04,643 --> 04:42:05,544 ABOUT IN YOUR COMMENTS ABOUT 8165 04:42:05,544 --> 04:42:06,178 THIS PARTICULAR PROGRAM. 8166 04:42:06,178 --> 04:42:08,080 SO IT WILL BE OPERATING AS SORT 8167 04:42:08,080 --> 04:42:15,487 OF A PIECE OF A LARGER VISION. 8168 04:42:15,487 --> 04:42:17,189 >> I THINK SO. 8169 04:42:17,189 --> 04:42:17,756 THAT'S A GOOD POINT. 8170 04:42:17,756 --> 04:42:19,491 WHEN I SAW THAT CHART THIS 8171 04:42:19,491 --> 04:42:20,225 MORNING, I THOUGHT THAT'S 8172 04:42:20,225 --> 04:42:21,427 EXACTLY WHAT THIS CONCEPT IS 8173 04:42:21,427 --> 04:42:21,627 ABOUT. 8174 04:42:21,627 --> 04:42:23,729 >> WELL, WE THINK IT'S REALLY A 8175 04:42:23,729 --> 04:42:26,965 GOOD FRAMEWORK FOR THIS BROADER 8176 04:42:26,965 --> 04:42:29,468 AMBITION THAT EVERYONE HAS, 8177 04:42:29,468 --> 04:42:31,136 WHICH IS TO INTEGRATE DATA 8178 04:42:31,136 --> 04:42:33,405 THAT'S COMMONLY ACQUIRED IN 8179 04:42:33,405 --> 04:42:34,706 CLINICAL INTERACTIONS AND GET 8180 04:42:34,706 --> 04:42:35,274 MORE OUT OF IT. 8181 04:42:35,274 --> 04:42:35,941 >> RIGHT. 8182 04:42:35,941 --> 04:42:38,177 >> AND THE IMAGING COMMUNITY HAS 8183 04:42:38,177 --> 04:42:41,246 BEEN DOING THAT BY COMBINING 8184 04:42:41,246 --> 04:42:46,151 PHYSICS MODELS WITH AI-BASED 8185 04:42:46,151 --> 04:42:47,653 APPROACHES SINCE I GUESS PEOPLE 8186 04:42:47,653 --> 04:42:49,121 STARTED DOING MACHINE LEARNING 8187 04:42:49,121 --> 04:42:50,622 IN THE 90s. 8188 04:42:50,622 --> 04:42:54,593 AND SO WE HOPE TO BUILD ON THAT 8189 04:42:54,593 --> 04:42:55,594 CULTURE, THE QUANTITATIVE 8190 04:42:55,594 --> 04:42:56,462 IMAGING BIOMARKERS PROGRAM THAT 8191 04:42:56,462 --> 04:43:01,366 WE STARTED AT NIBIB AND IS 8192 04:43:01,366 --> 04:43:03,202 CONTINUING WITH RSNA AND OTHER 8193 04:43:03,202 --> 04:43:03,869 EXTERNAL SUPPORT. 8194 04:43:03,869 --> 04:43:07,172 THE IMAGING PHANTOM TECHNOLOGY 8195 04:43:07,172 --> 04:43:08,807 PROGRAM THAT WE'VE STARTED WITH 8196 04:43:08,807 --> 04:43:09,942 NIST AND FDA SO WE CAN 8197 04:43:09,942 --> 04:43:12,778 DISTRIBUTE THOSE RESOURCES TO 8198 04:43:12,778 --> 04:43:15,114 OUR COMMUNITY TO HELP HARMONIZE 8199 04:43:15,114 --> 04:43:17,749 SOME ASPECTS OF DATA, AND THE 8200 04:43:17,749 --> 04:43:20,819 GENERAL ENGAGEMENT OF 8201 04:43:20,819 --> 04:43:23,122 PROFESSIONAL SOCIETIES LIKE AA 8202 04:43:23,122 --> 04:43:27,059 PM AND RSNA AND ACR, ESPECIALLY 8203 04:43:27,059 --> 04:43:28,927 THE PHYSICS AND ENGINEERING SIDE 8204 04:43:28,927 --> 04:43:29,495 WHERE PEOPLE ARE VERY, VERY 8205 04:43:29,495 --> 04:43:31,463 CONCERNED AND COGNIZANT OF THE 8206 04:43:31,463 --> 04:43:33,966 COMPUTATIONAL RESOURCES THAT ARE 8207 04:43:33,966 --> 04:43:35,467 NEEDED, AND ALWAYS WORRIED THAT 8208 04:43:35,467 --> 04:43:37,202 THESE KIND OF INVERSE PROBLEMS 8209 04:43:37,202 --> 04:43:38,437 THAT WE'RE TRYING TO SOLVE ARE 8210 04:43:38,437 --> 04:43:43,208 ILL POSED, AND ARE OBSESSIVE 8211 04:43:43,208 --> 04:43:44,176 ABOUT TRYING TO REDUCE BIAS IN 8212 04:43:44,176 --> 04:43:45,844 THE INPUT DATA THAT'S GOING IN. 8213 04:43:45,844 --> 04:43:46,945 SO WE THINK, AND WE'VE SEEN IN 8214 04:43:46,945 --> 04:43:51,016 THE PAST, HOW THIS COMBINATION 8215 04:43:51,016 --> 04:43:52,451 OF CULTURES CAN LEAD TO REALLY 8216 04:43:52,451 --> 04:43:55,521 BETTER OUTCOMES, AND IN 8217 04:43:55,521 --> 04:43:58,090 COMPARISON TO THE OPEN AI 8218 04:43:58,090 --> 04:44:00,159 APPROACHES AND STAR GATE AI, 8219 04:44:00,159 --> 04:44:01,593 THEY'RE REALLY PLOFFING QUICKLY 8220 04:44:01,593 --> 04:44:05,497 TOWARDS THE SUPER OBVIOUS OR 8221 04:44:05,497 --> 04:44:06,832 FAST COMMERCIALIZATION 8222 04:44:06,832 --> 04:44:07,166 OPPORTUNITIES. 8223 04:44:07,166 --> 04:44:09,601 THEY'VE IDENTIFIED MARKETS, 8224 04:44:09,601 --> 04:44:10,969 THEY'RE MOVING QUICKLY TO THAT, 8225 04:44:10,969 --> 04:44:14,973 AND BRINGING IN MORE BRUTE FORCE 8226 04:44:14,973 --> 04:44:16,408 TYPE OF LARGE LANGUAGE MODELS 8227 04:44:16,408 --> 04:44:17,376 AND GENERATIVE TECHNIQUES. 8228 04:44:17,376 --> 04:44:19,311 WE SEE A MORE REFINED APPROACH 8229 04:44:19,311 --> 04:44:21,813 FROM OUR COMMUNITY NOT 8230 04:44:21,813 --> 04:44:22,915 NECESSARILY THE BIG COMMERCIAL 8231 04:44:22,915 --> 04:44:24,316 MARKETS AT THE OUT IT IS SET BUT 8232 04:44:24,316 --> 04:44:26,185 GETTING TO TRUTHS THAT 8233 04:44:26,185 --> 04:44:28,987 CLINICIANS ARE SEEKING AND OUR 8234 04:44:28,987 --> 04:44:30,856 SCIENTISTS ARE SEEKING THAT ARE 8235 04:44:30,856 --> 04:44:32,090 RELATIVELY LOW HANGING BECAUSE 8236 04:44:32,090 --> 04:44:34,860 WE'RE JUST LEAVING SO MUCH 8237 04:44:34,860 --> 04:44:38,263 INFORMATION WHEN YOU GENERATE 8238 04:44:38,263 --> 04:44:39,464 THAT IMPRESSION FROM YOUR 8239 04:44:39,464 --> 04:44:40,766 RADIOLOGY REPORT, OH, MY GOSH, 8240 04:44:40,766 --> 04:44:44,703 THERE'S JUST SO MUCH MORE THERE. 8241 04:44:44,703 --> 04:44:46,238 SO THAT'S HOW WE'LL TRY TO 8242 04:44:46,238 --> 04:44:47,206 NAVIGATE BETWEEN THIS SORT OF 8243 04:44:47,206 --> 04:44:51,143 BIG, BIC MONEY REQUIREMENT AND 8244 04:44:51,143 --> 04:44:52,744 ENORMOUS -- AND YOU'RE 8245 04:44:52,744 --> 04:44:53,745 ABSOLUTELY CORRECT ON AN 8246 04:44:53,745 --> 04:44:55,147 ESTIMATE, BOTH THE MONEY AND THE 8247 04:44:55,147 --> 04:44:57,115 INFORMATION, THE DATA CONTENT, 8248 04:44:57,115 --> 04:45:00,419 THAT HAS TO GO FORWARD. 8249 04:45:00,419 --> 04:45:02,054 BUT I THINK WE'RE IN A UNIQUE 8250 04:45:02,054 --> 04:45:02,821 POSITION WITH OUR COMMUNITIES 8251 04:45:02,821 --> 04:45:04,189 WHERE WE CAN MAKE A LOT OF 8252 04:45:04,189 --> 04:45:05,090 PROGRESS RIGHT NOW IN THESE 8253 04:45:05,090 --> 04:45:08,260 AREAS THAT ARE NOT NECESSARILY 8254 04:45:08,260 --> 04:45:10,262 FOCUSED ON BY THE BIG CAPITAL 8255 04:45:10,262 --> 04:45:10,529 INTERESTS. 8256 04:45:10,529 --> 04:45:13,565 >> YEAH. 8257 04:45:13,565 --> 04:45:18,470 IN MARYLAND ACTUALLY, WE JUST -- 8258 04:45:18,470 --> 04:45:19,871 MONTGOMERY COUNTY AND ALSO THE 8259 04:45:19,871 --> 04:45:20,739 UNIVERSITY OF MARYLAND MEDICAL 8260 04:45:20,739 --> 04:45:22,274 SYSTEM, THEY JUST CREATED A NEW 8261 04:45:22,274 --> 04:45:23,375 INSTITUTE WITH THE MEDICAL 8262 04:45:23,375 --> 04:45:24,710 SCHOOL CALLED THE INSTITUTE OF 8263 04:45:24,710 --> 04:45:26,378 HEALTH COMPUTING, AND THEY 8264 04:45:26,378 --> 04:45:28,447 STARTED WITH $70 MILLION TO 8265 04:45:28,447 --> 04:45:30,349 START AND THEN THEY GOT THE 8266 04:45:30,349 --> 04:45:33,352 STATE TO AGREEL TO GIVE THEM -- 8267 04:45:33,352 --> 04:45:34,953 THIS IS OUR TAX DOLLARS -- TO 8268 04:45:34,953 --> 04:45:37,055 CONTINUE TO FUND THEM AT THE 8269 04:45:37,055 --> 04:45:38,790 TUNE OF ABOUT $6 MILLION A YEAR 8270 04:45:38,790 --> 04:45:40,192 JUST TO MAINTAIN IT, AND THEY'RE 8271 04:45:40,192 --> 04:45:41,727 DOING SOMETHING VERY SIMILAR TO 8272 04:45:41,727 --> 04:45:43,895 WHAT YOU ARE TALKING ABOUT. 8273 04:45:43,895 --> 04:45:45,130 THEY'RE STARTING WITH THE EHR 8274 04:45:45,130 --> 04:45:48,200 RECORD AND INPUTTING ALL THE 8275 04:45:48,200 --> 04:45:48,533 DATA. 8276 04:45:48,533 --> 04:45:50,902 IT'S NOT IMAGING-FOCUSED BUT 8277 04:45:50,902 --> 04:45:53,305 STILL THE CONCEPT IS THE SAME, 8278 04:45:53,305 --> 04:45:55,274 INTEGRATING CLINICAL WITH ALL 8279 04:45:55,274 --> 04:45:56,608 THE LABS AND EVERYTHING ELSE 8280 04:45:56,608 --> 04:46:02,848 THEY CAN GET TOGETHER TO IMPROVE 8281 04:46:02,848 --> 04:46:03,415 PREDICTION AND DIAGNOSIS FOR 8282 04:46:03,415 --> 04:46:03,915 PATIENTS. 8283 04:46:03,915 --> 04:46:05,284 SO ANYWAY, YOU MIGHT WANT TO 8284 04:46:05,284 --> 04:46:06,018 TALK TO THEM TOO. 8285 04:46:06,018 --> 04:46:07,486 THEY SEEM TO BE SPENDING A LOT 8286 04:46:07,486 --> 04:46:11,089 MORE MONEY ON WHAT THEY'RE 8287 04:46:11,089 --> 04:46:11,390 DOING, SO -- 8288 04:46:11,390 --> 04:46:13,525 >> YEAH, THANK YOU. 8289 04:46:13,525 --> 04:46:15,794 >> IT'S CALLED THE IHC, 8290 04:46:15,794 --> 04:46:17,296 INSTITUTE OF HEALTH COMPUTING. 8291 04:46:17,296 --> 04:46:17,963 THEY'RE ACTUALLY LOCATED ACROSS 8292 04:46:17,963 --> 04:46:22,567 THE STREET FROM YOU AT THE -- 8293 04:46:22,567 --> 04:46:22,768 AREA. 8294 04:46:22,768 --> 04:46:23,101 >> GREAT. 8295 04:46:23,101 --> 04:46:25,037 THANK YOU FOR THE SUGGESTIONS. 8296 04:46:25,037 --> 04:46:25,237 OKAY. 8297 04:46:25,237 --> 04:46:26,605 WE HAVE SEVERAL OTHER 8298 04:46:26,605 --> 04:46:27,606 COUNCILMEMBERS WHOSE HANDS ARE 8299 04:46:27,606 --> 04:46:28,807 RAISED TO CONTRIBUTE TO THE 8300 04:46:28,807 --> 04:46:30,275 DISCUSSION, SO I'M GOING TO TURN 8301 04:46:30,275 --> 04:46:35,380 TO RHONDA FIRST. 8302 04:46:35,380 --> 04:46:36,448 >> THANK YOU. 8303 04:46:36,448 --> 04:46:38,083 YOU TALK ABOUT REALLY INNOVATIVE 8304 04:46:38,083 --> 04:46:39,818 IDEA, THIS IS DEFINITELY ONE OF 8305 04:46:39,818 --> 04:46:43,522 THOSE BIG IDEAS BUT IT'S ALSO A 8306 04:46:43,522 --> 04:46:45,624 HUGE PROJECT. 8307 04:46:45,624 --> 04:46:46,825 THE THING THAT I FEAR THE MOST 8308 04:46:46,825 --> 04:46:48,427 BECAUSE THIS IS A DIRECTION THAT 8309 04:46:48,427 --> 04:46:53,365 MANY STAKEHOLDERS ARE GOING INTO 8310 04:46:53,365 --> 04:46:57,736 ALREADY, THAT IF IT'S NOT 8311 04:46:57,736 --> 04:47:01,773 MANAGED WELL WILL HAVE A MASSIVE 8312 04:47:01,773 --> 04:47:03,475 FRAGMENTATION OF ALL DIFFERENT 8313 04:47:03,475 --> 04:47:05,243 TYPES OF APPROACHS THAT WON'T 8314 04:47:05,243 --> 04:47:06,945 HAVE ANY INTEROPERABILITY AT ALL 8315 04:47:06,945 --> 04:47:11,717 AND JUST PROVIDE MORE CONFUSION. 8316 04:47:11,717 --> 04:47:13,218 SO I DO THINK -- ONE OF MY 8317 04:47:13,218 --> 04:47:15,520 QUESTIONS IS, WHAT IS THE MOST 8318 04:47:15,520 --> 04:47:19,157 UNIQUE AND VALUABLE ROLE THAT 8319 04:47:19,157 --> 04:47:20,325 NIH WOULD PLAY IN THIS? 8320 04:47:20,325 --> 04:47:23,061 AND THERE ARE SOME UNIQUE 8321 04:47:23,061 --> 04:47:24,696 CAPABILITIES THAT YOU HAVE THAT 8322 04:47:24,696 --> 04:47:27,232 I THINK WOULD BE VERY, VERY 8323 04:47:27,232 --> 04:47:29,267 IMPORTANT IN MOVING THIS FORWARD 8324 04:47:29,267 --> 04:47:32,738 AS A NATIONAL PROCESS. 8325 04:47:32,738 --> 04:47:34,606 I DO THINK THAT ONE OF THE 8326 04:47:34,606 --> 04:47:36,742 THINGS THAT YOU DO HAVE IN YOUR 8327 04:47:36,742 --> 04:47:40,245 BACK POCKET IS THAT YOU CAN, 8328 04:47:40,245 --> 04:47:41,246 BECAUSE OF YOUR POSITION, 8329 04:47:41,246 --> 04:47:42,581 BECAUSE OF HOW YOU'RE FUNDED, 8330 04:47:42,581 --> 04:47:46,218 THAT YOU WOULD HAVE SOME 8331 04:47:46,218 --> 04:47:48,086 REGULATORY NAVIGATION SKILLS AND 8332 04:47:48,086 --> 04:47:48,954 CREDIBILITY, SO THAT THAT'S 8333 04:47:48,954 --> 04:47:52,357 GOING TO BE IMPORTANT TO BEGIN 8334 04:47:52,357 --> 04:47:55,594 TO BRING IN OR HONE IN WHAT 8335 04:47:55,594 --> 04:47:57,996 NEEDS TO BE STANDARD AND WHAT 8336 04:47:57,996 --> 04:47:59,631 ISN'T, AND YOU ALSO HAVE THE 8337 04:47:59,631 --> 04:48:02,300 ABILITY TO TEST OUT THROUGH YOUR 8338 04:48:02,300 --> 04:48:04,836 FUNDING, THROUGH OTHERS DOING 8339 04:48:04,836 --> 04:48:06,104 IT, BUT HAVING THE GUIDELINES OR 8340 04:48:06,104 --> 04:48:08,440 THE WAY OF TESTING SOMETHING TO 8341 04:48:08,440 --> 04:48:11,176 BE ABLE TO DECLARE IT AS A 8342 04:48:11,176 --> 04:48:13,879 STANDARD IN SOME WAY. 8343 04:48:13,879 --> 04:48:15,414 I THINK THAT'S VERY, VERY MUCH 8344 04:48:15,414 --> 04:48:19,751 SO IN YOUR AREA. 8345 04:48:19,751 --> 04:48:23,155 I AGREE WITH THE LAST PERSON WHO 8346 04:48:23,155 --> 04:48:24,122 COMMENTED, THE AMOUNT OF MONEY 8347 04:48:24,122 --> 04:48:26,825 IN THIS IS JUST TREMENDOUS, I 8348 04:48:26,825 --> 04:48:29,795 DON'T SEE THIS BEING NIH-FUNDED, 8349 04:48:29,795 --> 04:48:31,430 BUT I DO SEE THERE ARE MULTIPLE 8350 04:48:31,430 --> 04:48:32,831 INVESTORS OUT THERE THAT ARE IN 8351 04:48:32,831 --> 04:48:34,833 THIS. 8352 04:48:34,833 --> 04:48:36,701 BUT I THINK WITH A STRONG SENSE 8353 04:48:36,701 --> 04:48:39,337 OF A REGULATORY PIECE THAT IS 8354 04:48:39,337 --> 04:48:43,742 GOING TO BE APPLIED TO THIS WILL 8355 04:48:43,742 --> 04:48:46,044 HELP BRING SOME OF THOSE 8356 04:48:46,044 --> 04:48:49,014 INVESTORS WHO WANT TO BE IN THIS 8357 04:48:49,014 --> 04:48:50,582 SPACE TO START WORKING WITH YOU, 8358 04:48:50,582 --> 04:48:51,716 BECAUSE I THINK THAT'S GOING TO 8359 04:48:51,716 --> 04:48:52,918 BE EXCEPTIONALLY IMPORTANT IN 8360 04:48:52,918 --> 04:48:56,221 TERMS OF BRINGING THE 8361 04:48:56,221 --> 04:48:57,856 CONTINUITY, THE STANDARDIZATION 8362 04:48:57,856 --> 04:48:59,124 AND ALL OF THAT THAT WILL ALLOW 8363 04:48:59,124 --> 04:48:59,758 THIS TO WORK. 8364 04:48:59,758 --> 04:49:04,229 OTHER THAN THAT, I TAKE MY HAT 8365 04:49:04,229 --> 04:49:05,764 OFF TO YOU TO SAY THIS IS A HUGE 8366 04:49:05,764 --> 04:49:06,531 PROJECT, EXCEPTIONALLY 8367 04:49:06,531 --> 04:49:07,632 IMPORTANT, THERE ARE A LOT OF 8368 04:49:07,632 --> 04:49:08,733 ORGANIZATIONS THAT ARE DOING 8369 04:49:08,733 --> 04:49:14,406 THIS THAT HAVE LOTS OF KIND OF 8370 04:49:14,406 --> 04:49:16,274 DATA AND I THINK THERE'S A WAY 8371 04:49:16,274 --> 04:49:20,479 OF CAPITALIZING OFF WHAT'S BEEN 8372 04:49:20,479 --> 04:49:22,681 STARTED, FIGURING OUT WHAT YOUR 8373 04:49:22,681 --> 04:49:24,549 UNIQUE ROLE, WHAT YOU'RE 8374 04:49:24,549 --> 04:49:25,817 UNIQUELY CAPABLE OF DOING THAT 8375 04:49:25,817 --> 04:49:26,918 THEY CANNOT, AND ALSO 8376 04:49:26,918 --> 04:49:27,919 RECOGNIZING THAT THE 8377 04:49:27,919 --> 04:49:29,654 STANDARDIZATION OF DATA BUT ALSO 8378 04:49:29,654 --> 04:49:31,223 THE ALGORITHMS AND ALL OF THAT 8379 04:49:31,223 --> 04:49:33,558 NEEDS TO BE HELD BY SOMETHING 8380 04:49:33,558 --> 04:49:35,961 THAT HAS TESTED IT OUT AND CAN 8381 04:49:35,961 --> 04:49:38,129 DEMONSTRATE TO THOSE WHO ARE 8382 04:49:38,129 --> 04:49:39,664 PARTICIPATING WHAT IS MORE 8383 04:49:39,664 --> 04:49:41,099 VALUABLE, WHAT'S MORE VALID IN 8384 04:49:41,099 --> 04:49:41,733 THE LONG RUN. 8385 04:49:41,733 --> 04:49:43,401 SO THANK YOU FOR THE OPPORTUNITY 8386 04:49:43,401 --> 04:49:49,808 TO COMMENT. 8387 04:49:49,808 --> 04:49:50,408 >> THANK YOU. 8388 04:49:50,408 --> 04:49:54,145 MIKE, DO YOU WANT TO START? 8389 04:49:54,145 --> 04:49:56,348 >> RHONDA, I WOULD JUST SAY 8390 04:49:56,348 --> 04:49:56,615 THANK YOU. 8391 04:49:56,615 --> 04:49:57,749 I SEE A LOT OF HANDS RAISED SO I 8392 04:49:57,749 --> 04:49:59,951 DON'T WANT TO TALK TOO LONG 8393 04:49:59,951 --> 04:50:03,054 EXCEPT TO SAY THANK YOU VERY 8394 04:50:03,054 --> 04:50:03,788 MUCH. 8395 04:50:03,788 --> 04:50:04,856 WE HAVEN'T MET BUT I SEE WHERE 8396 04:50:04,856 --> 04:50:07,425 YOU'RE FROM AND I WOULD LOVE TO 8397 04:50:07,425 --> 04:50:09,227 SORT OF HAVE FUTURE 8398 04:50:09,227 --> 04:50:12,264 CONVERSATIONS ABOUT THIS. 8399 04:50:12,264 --> 04:50:13,164 YOU MENTIONED A LOT OF -- I FEEL 8400 04:50:13,164 --> 04:50:16,167 LIKE YOU ANSWERED THE QUESTION 8401 04:50:16,167 --> 04:50:19,271 THAT YOU ASKED IN SOME WAYS, 8402 04:50:19,271 --> 04:50:20,472 VALIDATION STANDARDS, WORKING 8403 04:50:20,472 --> 04:50:21,907 ACROSS FEDERAL AGENCIES LIKE 8404 04:50:21,907 --> 04:50:24,609 FDA, CMS AND OTHER PAYOR, 8405 04:50:24,609 --> 04:50:26,244 PUBLIC-PRIVATE PARTNERSHIPS AND 8406 04:50:26,244 --> 04:50:27,412 ULTIMATELY WE WANT TO TRY TO 8407 04:50:27,412 --> 04:50:28,513 ADVANCE A WHOLE THAT'S GREATER 8408 04:50:28,513 --> 04:50:30,148 THAN THE SUM OF THE PARTS, NOT 8409 04:50:30,148 --> 04:50:31,783 ONE THAT'S AS YOU SAID 8410 04:50:31,783 --> 04:50:32,851 FRAGMENTED AND LESS THAN THE SUM 8411 04:50:32,851 --> 04:50:35,020 OF THE PARTS BECAUSE IT'S ALL 8412 04:50:35,020 --> 04:50:35,654 CONFUSING AND I DO THINK WE CAN 8413 04:50:35,654 --> 04:50:37,689 PLAY A BIG ROLE IN THAT AT NIH. 8414 04:50:37,689 --> 04:50:38,590 BUT THANK YOU. 8415 04:50:38,590 --> 04:50:41,693 >> AND SO JUST ADDING ON TO 8416 04:50:41,693 --> 04:50:42,827 MIKE'S COMMENT, WE'RE GOING TO 8417 04:50:42,827 --> 04:50:44,796 BRING TO BEAR ALL OF THE 8418 04:50:44,796 --> 04:50:45,997 EXPERIENCES AND RESOURCES THAT 8419 04:50:45,997 --> 04:50:48,700 WE'VE HAD COLLECTIVELY AS OUR 8420 04:50:48,700 --> 04:50:51,002 NIH COMMUNITY, AND THOSE 8421 04:50:51,002 --> 04:50:52,871 INVOLVED BUILDING NEW 8422 04:50:52,871 --> 04:50:54,172 CAPABILITIES IN EXACTLY THOSE 8423 04:50:54,172 --> 04:50:55,974 AREAS THAT YOU MENTIONED. 8424 04:50:55,974 --> 04:50:58,376 SO WE HAVE VERY STRONG 8425 04:50:58,376 --> 04:51:02,180 RELATIONSHIPS WITH CDRH, DIGITAL 8426 04:51:02,180 --> 04:51:04,583 HEALTH, THE OHTs WITHIN THE 8427 04:51:04,583 --> 04:51:06,351 FDA, AND IN THE 8428 04:51:06,351 --> 04:51:07,218 COMMERCIALIZATION COMMUNITY, 8429 04:51:07,218 --> 04:51:11,489 WHERE WE CAN BRING EXPERTS IN TO 8430 04:51:11,489 --> 04:51:14,492 SHARPEN AND REFINE IDEAS AND 8431 04:51:14,492 --> 04:51:16,795 THEN TO VALIDATE AND TEST THE 8432 04:51:16,795 --> 04:51:18,330 ALGORITHMS THAT ARE UNDER 8433 04:51:18,330 --> 04:51:20,966 DEVELOPMENT AND GET TO A DEEPER 8434 04:51:20,966 --> 04:51:22,601 UNDERSTANDING OF EXACTLY HOW 8435 04:51:22,601 --> 04:51:24,235 THEY WORK AND POTENTIAL MARKETS 8436 04:51:24,235 --> 04:51:25,537 FOR THIS. 8437 04:51:25,537 --> 04:51:28,173 SO WE ARE -- WE HAVE SOME UNIQUE 8438 04:51:28,173 --> 04:51:30,742 SKILLSETS AND CAPABILITIES AT 8439 04:51:30,742 --> 04:51:31,710 THE NIH EXACTLY IN THE AREAS 8440 04:51:31,710 --> 04:51:33,378 THAT YOU BROUGHT UP, AND WE ARE 8441 04:51:33,378 --> 04:51:34,879 ABSOLUTELY GOING TO HAVE TO 8442 04:51:34,879 --> 04:51:35,547 BRING THEM TO BEAR IN THIS 8443 04:51:35,547 --> 04:51:37,949 PROGRAM. 8444 04:51:37,949 --> 04:51:40,151 >> AND I THINK ABOUT IT FROM THE 8445 04:51:40,151 --> 04:51:40,885 STANDPOINT OF VIEW OF 8446 04:51:40,885 --> 04:51:42,087 INVESTMENTS THAT ARE BEING MADE 8447 04:51:42,087 --> 04:51:45,223 AND THAT WILL BE MADE, AND WHAT 8448 04:51:45,223 --> 04:51:46,658 WOULD DRAW INDIVIDUALS TO INVEST 8449 04:51:46,658 --> 04:51:49,628 IN A UNIFORM APPROACH. 8450 04:51:49,628 --> 04:51:51,596 WHAT WOULD BRING THE VALUE TO 8451 04:51:51,596 --> 04:51:51,930 THEM? 8452 04:51:51,930 --> 04:51:53,999 AND I THINK THAT'S EXCEPTIONALLY 8453 04:51:53,999 --> 04:51:56,101 IMPORTANT BECAUSE I'M SORRY, NIH 8454 04:51:56,101 --> 04:51:57,335 CANNOT PAY FOR ALL OF THIS. 8455 04:51:57,335 --> 04:52:00,405 THIS IS JUST TOO LARGE, TOO 8456 04:52:00,405 --> 04:52:00,639 COSTLY. 8457 04:52:00,639 --> 04:52:02,474 SO YOU'RE GOING TO NEED TO HAVE 8458 04:52:02,474 --> 04:52:05,076 THOSE WHO ARE CONTRIBUTING IN A 8459 04:52:05,076 --> 04:52:06,511 WAY THAT WOULD MAKE THIS PROJECT 8460 04:52:06,511 --> 04:52:08,913 KEEP GOING AND KEEP GOING ON THE 8461 04:52:08,913 --> 04:52:10,348 LARGE SCALE THAT YOU ARE 8462 04:52:10,348 --> 04:52:10,682 ANTICIPATING. 8463 04:52:10,682 --> 04:52:14,519 THANK YOU. 8464 04:52:14,519 --> 04:52:16,287 >> THANK YOU, RHONDA. 8465 04:52:16,287 --> 04:52:19,491 RAFAEL? 8466 04:52:19,491 --> 04:52:20,659 >> HI, THANK YOU. 8467 04:52:20,659 --> 04:52:23,928 SO I WANT TO SHARE MY MAIN 8468 04:52:23,928 --> 04:52:28,199 CONCERN ABOUT THIS PROPOSAL AND 8469 04:52:28,199 --> 04:52:30,168 IT'S THE -- IT RELATES TO WHY 8470 04:52:30,168 --> 04:52:32,070 IT'S FAILED SO MANY TIMES AND SO 8471 04:52:32,070 --> 04:52:33,338 MANY INSTITUTIONS. 8472 04:52:33,338 --> 04:52:35,407 AND IT HAS TO DO WITH THE 8473 04:52:35,407 --> 04:52:37,509 DIFFICULTY IN SHARING DATA, 8474 04:52:37,509 --> 04:52:38,276 CLINICAL DATA. 8475 04:52:38,276 --> 04:52:40,111 THERE'S SO MANY REGULATIONS AND 8476 04:52:40,111 --> 04:52:44,382 CONCERNS ABOUT PRIVACY AND 8477 04:52:44,382 --> 04:52:45,684 HOLDING FROM INVESTIGATORS THAT 8478 04:52:45,684 --> 04:52:49,154 GET TO WRITE MORE PAPERS, I'VE 8479 04:52:49,154 --> 04:52:50,689 YET TO SEE ANY INSTITUTION 8480 04:52:50,689 --> 04:52:51,790 SUCCEED AND IT'S NOT BECAUSE OF 8481 04:52:51,790 --> 04:52:53,324 LACK OF MACHINE LEARNING METHOD, 8482 04:52:53,324 --> 04:52:54,859 IT'S NOT BECAUSE OF LACK OF DATA 8483 04:52:54,859 --> 04:52:55,293 FOR SURE. 8484 04:52:55,293 --> 04:52:57,262 IT'S JUST -- IT'S LACK OF THE 8485 04:52:57,262 --> 04:53:00,432 ABILITY TO SHARE DATA AND I 8486 04:53:00,432 --> 04:53:01,966 DON'T KNOW IF IT'S THE CASE, BUT 8487 04:53:01,966 --> 04:53:04,803 IT DOES SEEM LIKE THE ONE BIG 8488 04:53:04,803 --> 04:53:08,339 DRIVER OF THAT ARE NIH 8489 04:53:08,339 --> 04:53:11,276 REGULATIONS THAT HAVE THIS 8490 04:53:11,276 --> 04:53:12,877 INDIRECT EFFECT OF MAKING IT 8491 04:53:12,877 --> 04:53:17,082 HARD TO SHARE, EVEN WITHIN 8492 04:53:17,082 --> 04:53:25,356 INSTITUTIONS. 8493 04:53:25,356 --> 04:53:26,991 THERE'S ALSO PLENTY OF EXAMPLES 8494 04:53:26,991 --> 04:53:28,660 WHERE MACHINE LEARNING EXPERT 8495 04:53:28,660 --> 04:53:30,495 CLAIMS VICTORY, PA THOL JITSES, 8496 04:53:30,495 --> 04:53:32,363 RADIOLOGISTS ARE NO LONGER 8497 04:53:32,363 --> 04:53:34,232 NEEDED MY METHOD IS BETTER THAN 8498 04:53:34,232 --> 04:53:35,200 THEM, THEY GET A SCIENCE PAPER, 8499 04:53:35,200 --> 04:53:36,835 BUT THEN WHEN THEY TRY IT AT ANY 8500 04:53:36,835 --> 04:53:38,303 OTHER HOSPITAL, IT FAILS 8501 04:53:38,303 --> 04:53:38,603 COMPLETELY. 8502 04:53:38,603 --> 04:53:43,374 SO YOU NEED TO TEST ACROSS 8503 04:53:43,374 --> 04:53:47,846 HOSPITALS, AND ACROSS 8504 04:53:47,846 --> 04:53:48,613 MEASUREMENT, WHEREVER 8505 04:53:48,613 --> 04:53:50,014 MEASUREMENTS ARE BEING TAKEN, 8506 04:53:50,014 --> 04:53:56,054 AND JUST TO DEVELOP METHODS THAT 8507 04:53:56,054 --> 04:53:57,555 ARE ROBUST TO THAT, WHICH I 8508 04:53:57,555 --> 04:54:00,058 DON'T THINK ARE AROUND YET, YOU 8509 04:54:00,058 --> 04:54:02,160 HAVE TO SHARE DATA ACROSS SITES. 8510 04:54:02,160 --> 04:54:04,896 WE CAN'T EVEN SHARE DATA WITHIN 8511 04:54:04,896 --> 04:54:05,964 SITES, HOW ARE WE GOING TO SHARE 8512 04:54:05,964 --> 04:54:07,298 DATA ACROSS SITES? 8513 04:54:07,298 --> 04:54:08,733 THAT DOES SEEM TO BE NOT A 8514 04:54:08,733 --> 04:54:10,301 TECHNICAL OR SCIENTIFIC PROBLEM, 8515 04:54:10,301 --> 04:54:11,436 IT SEEMS TO BE COMPLETELY A 8516 04:54:11,436 --> 04:54:13,938 POLITICAL PROBLEM. 8517 04:54:13,938 --> 04:54:16,141 AND A LOT OF IT HAVING TO DO 8518 04:54:16,141 --> 04:54:18,376 WITH PRIVACY REGULATIONS, WHICH 8519 04:54:18,376 --> 04:54:20,011 MAYBE THEY'RE NECESSARY, BUT I 8520 04:54:20,011 --> 04:54:22,781 DON'T THINK WE CAN HAVE BOTH THE 8521 04:54:22,781 --> 04:54:24,716 PRIVACY REGULATIONS AND THE 8522 04:54:24,716 --> 04:54:26,785 ABILITY TO SHARE DATA AS WE NEED 8523 04:54:26,785 --> 04:54:28,219 TO TO MAKE THIS SUCCEED. 8524 04:54:28,219 --> 04:54:30,321 SO I'M WONDERING IF THERE WILL 8525 04:54:30,321 --> 04:54:32,323 BE SOME KIND OF INCENTIVE OR 8526 04:54:32,323 --> 04:54:35,827 SOME KIND OF PROCEDURE TO 8527 04:54:35,827 --> 04:54:36,928 FACILITATE THIS HURDLE THAT'S 8528 04:54:36,928 --> 04:54:40,865 BEEN AROUND FOR 20 YEARS NOW. 8529 04:54:40,865 --> 04:54:42,500 AND HAS KEPT PEOPLE FROM 8530 04:54:42,500 --> 04:54:43,268 SUCCEEDING AT PROJECTS LIKE 8531 04:54:43,268 --> 04:54:43,468 THIS. 8532 04:54:43,468 --> 04:54:47,005 THANK YOU. 8533 04:54:47,005 --> 04:54:50,608 >> RAFAEL, THANK YOU FOR RAISING 8534 04:54:50,608 --> 04:54:50,909 THAT. 8535 04:54:50,909 --> 04:54:52,944 AS I SEE IT, YOU'VE MENTIONED 8536 04:54:52,944 --> 04:54:53,978 TWO CONCEPTS. 8537 04:54:53,978 --> 04:54:57,615 ONE IS TESTING ACROSS HOSPITALS. 8538 04:54:57,615 --> 04:54:57,916 VALIDATION. 8539 04:54:57,916 --> 04:55:00,552 AND I THINK THAT'S EXTREMELY 8540 04:55:00,552 --> 04:55:00,985 IMPORTANT. 8541 04:55:00,985 --> 04:55:02,086 THAT'S EXACTLY THE PREMISE OF 8542 04:55:02,086 --> 04:55:03,555 WHAT WE'RE TRYING TO ADDRESS 8543 04:55:03,555 --> 04:55:04,923 WITH THIS VALIDATION CENTER, TO 8544 04:55:04,923 --> 04:55:06,224 PROVE THAT WE HAVE 8545 04:55:06,224 --> 04:55:08,092 GENERALIZABILITY. 8546 04:55:08,092 --> 04:55:10,028 YOUR BIGGER COMMENT WAS ABOUT 8547 04:55:10,028 --> 04:55:11,329 DATA SHARING AND CULTURE AND 8548 04:55:11,329 --> 04:55:12,096 REGULATIONS. 8549 04:55:12,096 --> 04:55:13,598 TOTALLY, TOTALLY, TOTALLY, 8550 04:55:13,598 --> 04:55:15,800 TOTALLY AGREE WITH THAT. 8551 04:55:15,800 --> 04:55:19,637 WE PUBLISHED AN NIH DATA SHARING 8552 04:55:19,637 --> 04:55:21,139 REQUIREMENT TWO YEARS AGO AND 8553 04:55:21,139 --> 04:55:22,106 THE COMMUNITY HATES IT. 8554 04:55:22,106 --> 04:55:22,974 FOR EXACTLY THE REASON THAT YOU 8555 04:55:22,974 --> 04:55:23,641 MENTIONED. 8556 04:55:23,641 --> 04:55:24,742 WE'VE HEARD EVERY SINGLE 8557 04:55:24,742 --> 04:55:25,910 COMPLAINT. 8558 04:55:25,910 --> 04:55:26,945 AND I JUST WANTED TO HIGHLIGHT 8559 04:55:26,945 --> 04:55:28,213 ONE THING THAT I BELIEVE YOU 8560 04:55:28,213 --> 04:55:31,482 HEARD IN THE SCIENCE OF SCIENCE 8561 04:55:31,482 --> 04:55:34,419 THING, IT'S OUR FIRM BELIEF THAT 8562 04:55:34,419 --> 04:55:35,753 THESE ARE THE SMARTEST PEOPLE IN 8563 04:55:35,753 --> 04:55:37,188 THE WORLD THAT WE'RE DEALING 8564 04:55:37,188 --> 04:55:40,225 WITH AND IF WE INCENTIVIZE 8565 04:55:40,225 --> 04:55:41,492 PEOPLE TO WANT TO DO SOMETHING, 8566 04:55:41,492 --> 04:55:42,727 THEY WILL WANT TO DO T WE'VE 8567 04:55:42,727 --> 04:55:44,462 REALLY BEEN TRYING TO PUSH THIS 8568 04:55:44,462 --> 04:55:47,232 NIH DATA SHARING SO CALLED S 8569 04:55:47,232 --> 04:55:49,167 INDEX CHALLENGE. 8570 04:55:49,167 --> 04:55:50,802 CAN WE DEVELOP A METRIC THAT 8571 04:55:50,802 --> 04:55:54,172 WILL GO UP IF YOU SHARE MORE 8572 04:55:54,172 --> 04:55:56,040 DATA AND IT'S GOOD AND CAN WE 8573 04:55:56,040 --> 04:55:58,676 GET -- CAN WE WORK WITH GOOGLE 8574 04:55:58,676 --> 04:56:00,879 SCHOLAR, PICK YOUR DIFFERENT -- 8575 04:56:00,879 --> 04:56:03,281 PEOPLE REALLY PUBLICIZE THIS AND 8576 04:56:03,281 --> 04:56:04,482 GET INTO PROMOTION AND TENURES, 8577 04:56:04,482 --> 04:56:05,483 I THINK THAT'S ONE OF THE WAYS 8578 04:56:05,483 --> 04:56:07,218 THAT WE CAN HELP DRIVE CULTURE 8579 04:56:07,218 --> 04:56:08,853 CHANGE TO REALLY PUSH THIS 8580 04:56:08,853 --> 04:56:09,954 FORWARD AND ADDRESS THE THINGS 8581 04:56:09,954 --> 04:56:10,922 THAT YOU'RE TALKING ABOUT. 8582 04:56:10,922 --> 04:56:12,590 SO RAFAEL, THANK YOU. 8583 04:56:12,590 --> 04:56:13,458 >> THAT'S ALL RIGHT. 8584 04:56:13,458 --> 04:56:17,695 I HAVE A COULD A CONCRETE SUGGEN 8585 04:56:17,695 --> 04:56:18,396 WHICH IS TO MAKE PEOPLE PUT 8586 04:56:18,396 --> 04:56:19,797 THEIR MONEY WHERE THEIR MOUTH 8587 04:56:19,797 --> 04:56:20,131 IS. 8588 04:56:20,131 --> 04:56:21,299 YOU COULD HAVE A REQUIREMENT FOR 8589 04:56:21,299 --> 04:56:22,567 THE FUNDING OPPORTUNITY, THAT IF 8590 04:56:22,567 --> 04:56:24,168 YOU CAN'T DEMONSTRATE THAT IN 8591 04:56:24,168 --> 04:56:28,306 YOUR INSTITUTION, YOU'RE NOT 8592 04:56:28,306 --> 04:56:30,708 SHARING DATA, EHR DATA IS STUCK 8593 04:56:30,708 --> 04:56:32,944 IN ONE PLACE, JUST ONE 8594 04:56:32,944 --> 04:56:33,878 INVESTIGATOR THAT SOMEHOW 8595 04:56:33,878 --> 04:56:35,313 HAPPENED TO GET THEIR HANDS ON 8596 04:56:35,313 --> 04:56:36,381 IT, THEN THEY DON'T GET TO 8597 04:56:36,381 --> 04:56:36,681 PARTICIPATE. 8598 04:56:36,681 --> 04:56:38,349 I DON'T KNOW IF THERE'S A WAY TO 8599 04:56:38,349 --> 04:56:43,154 DO THAT, BUT I THINK UNDER THE 8600 04:56:43,154 --> 04:56:43,922 INSTITUTIONAL METRIC THAT WE 8601 04:56:43,922 --> 04:56:45,790 HAVE IN GRANTS, WE MIGHT REQUIRE 8602 04:56:45,790 --> 04:56:47,759 THAT THEY DEMONSTRATE VERY 8603 04:56:47,759 --> 04:56:49,928 CLEARLY THAT THEY ARE, IN FACT, 8604 04:56:49,928 --> 04:56:54,399 CAPABLE OF SHARING DATA. 8605 04:56:54,399 --> 04:56:55,300 OTHERWISE YOU'RE GOING TO GIVE 8606 04:56:55,300 --> 04:56:58,670 FUNDING TO AN INSTITUTION AND 8607 04:56:58,670 --> 04:56:59,537 THEY'RE JUST -- IT'S IMPOSSIBLE 8608 04:56:59,537 --> 04:57:00,772 FOR THEM OR THEY DON'T WANT TO 8609 04:57:00,772 --> 04:57:03,608 DO IT AND YOU WANT TO GET STUCK 8610 04:57:03,608 --> 04:57:04,776 WITH -- MAYBE THEY'LL HAVE 8611 04:57:04,776 --> 04:57:05,543 PAPERS BUT THEY WON'T ACTUALLY 8612 04:57:05,543 --> 04:57:08,413 HELP YOU SUCCEED. 8613 04:57:08,413 --> 04:57:11,215 >> MAYBE I COULD JUST JUMP IN, 8614 04:57:11,215 --> 04:57:12,884 WE'LL BUILD -- WE HAVE SOME 8615 04:57:12,884 --> 04:57:14,085 SUCCESSES IN THE IMAGING 8616 04:57:14,085 --> 04:57:15,954 COMMUNITY, SOME PRECEDENCE, SO I 8617 04:57:15,954 --> 04:57:18,690 MENTIONED THE MIDRC CONSORTIUM, 8618 04:57:18,690 --> 04:57:20,858 WHICH IS 24 DIFFERENT 8619 04:57:20,858 --> 04:57:23,127 INSTITUTIONS AND THREE MAJOR -- 8620 04:57:23,127 --> 04:57:24,128 >> ABSOLUTELY. 8621 04:57:24,128 --> 04:57:26,064 I'M MORE CONCERNED ABOUT EHR. 8622 04:57:26,064 --> 04:57:27,699 >> WELL, THAT GROUP ACTUALLY -- 8623 04:57:27,699 --> 04:57:31,536 IT TOOK A COUPLE OF YEARS, FIRST 8624 04:57:31,536 --> 04:57:34,272 TO SHARE THE IMAGING DATA, AND 8625 04:57:34,272 --> 04:57:37,108 NOW THE OTHER -- THE EHR AND 8626 04:57:37,108 --> 04:57:38,476 CLINICAL DATA IS BEGINNING TO 8627 04:57:38,476 --> 04:57:39,544 FLOW. 8628 04:57:39,544 --> 04:57:42,080 SO IT'S BEEN A STRUGGLE, BUT I 8629 04:57:42,080 --> 04:57:46,217 THINK THAT AS PEOPLE SEE THE 8630 04:57:46,217 --> 04:57:47,752 OPPORTUNITIES AND ADVANTAGES AND 8631 04:57:47,752 --> 04:57:48,619 SYSTEMS THAT ARE STRUCTURED IN A 8632 04:57:48,619 --> 04:57:50,788 WAY THAT CAN HELP FACILITATE IT, 8633 04:57:50,788 --> 04:57:53,658 THEY'LL EMULATE THOSE HOPEFULLY 8634 04:57:53,658 --> 04:57:55,193 AS WE PROGRESS. 8635 04:57:55,193 --> 04:58:00,431 IT ALSO BRINGS UP THE FEDERATED 8636 04:58:00,431 --> 04:58:01,432 LEARNING APPROACH AND SOMETIMES 8637 04:58:01,432 --> 04:58:04,235 THAT'S THE OPTION TO MOVE 8638 04:58:04,235 --> 04:58:06,204 TOWARDS AS ONCE YOU'VE EXHAUSTED 8639 04:58:06,204 --> 04:58:07,772 YOUR DATA REPOSITORIES FROM A 8640 04:58:07,772 --> 04:58:09,307 FEW DIFFERENT SITES AND THEN YOU 8641 04:58:09,307 --> 04:58:13,544 WANT TO ENGAGE OTHER PARTNERS 8642 04:58:13,544 --> 04:58:14,779 AND OTHER SITES. 8643 04:58:14,779 --> 04:58:16,247 BUT DEFINITELY BIG PROBLEM. 8644 04:58:16,247 --> 04:58:22,920 >> THANK YOU. 8645 04:58:22,920 --> 04:58:24,255 >> MOVING TO RUSSELL. 8646 04:58:24,255 --> 04:58:25,423 >> GREAT. 8647 04:58:25,423 --> 04:58:28,593 THANK YOU BOTH FOR A PHENOMENAL 8648 04:58:28,593 --> 04:58:28,926 PRESENTATION. 8649 04:58:28,926 --> 04:58:30,728 THIS IS OBVIOUSLY SO IMPORTANT 8650 04:58:30,728 --> 04:58:35,400 TO THE FUTURE OF ALL OF MEDICINE 8651 04:58:35,400 --> 04:58:36,134 ANDLY APPRECIATE YOU BRINGING 8652 04:58:36,134 --> 04:58:37,468 THIS FORWARD AS AN INITIATIVE. 8653 04:58:37,468 --> 04:58:40,705 I WANT TO ADDRESS A LITTLE BIT 8654 04:58:40,705 --> 04:58:42,173 OF RAFAEL'S COMMENTS AND KEVIN'S 8655 04:58:42,173 --> 04:58:43,808 COMMENTS AND THEN I HAVE A 8656 04:58:43,808 --> 04:58:48,846 QUESTION. 8657 04:58:48,846 --> 04:58:50,581 KEVIN'S COMMENTS WITH RESPECT TO 8658 04:58:50,581 --> 04:58:51,816 AI READY AND THE LESSONS 8659 04:58:51,816 --> 04:58:52,884 LEARNED, COULD NOT AGREE MORE. 8660 04:58:52,884 --> 04:58:55,253 I'VE HAD A RINGSIDE SEAT FROM 8661 04:58:55,253 --> 04:58:57,722 THE CONCEPT CLEARANCE FOUR YEARS 8662 04:58:57,722 --> 04:59:00,792 AGO AND ONE OF THE MAJOR 8663 04:59:00,792 --> 04:59:01,993 PROGRAMS IS BASED AT MY 8664 04:59:01,993 --> 04:59:04,195 UNIVERSITY, SO I'VE GOTTEN TO 8665 04:59:04,195 --> 04:59:05,496 SEE HOW THAT HAS PROGRESSED AND 8666 04:59:05,496 --> 04:59:07,565 IT HAS BEEN REMARKABLE. 8667 04:59:07,565 --> 04:59:11,402 FIRST OF ALL, THE OVERCOMING 8668 04:59:11,402 --> 04:59:12,070 CHALLENGES TO CREATING THESE 8669 04:59:12,070 --> 04:59:13,604 DATASETS WAS SIGNIFICANTLY 8670 04:59:13,604 --> 04:59:15,006 GREATER THAN ONE WOULD HAVE 8671 04:59:15,006 --> 04:59:17,075 ANTICIPATED, AND THAT DID GET 8672 04:59:17,075 --> 04:59:18,409 INTO INTEROPERABILITY ISSUES, 8673 04:59:18,409 --> 04:59:19,911 DATA SHARING ISSUES. 8674 04:59:19,911 --> 04:59:21,712 THE TRIVIAL THINGS OF, YOU KNOW, 8675 04:59:21,712 --> 04:59:23,014 MEMORANDA OF UNDERSTANDING 8676 04:59:23,014 --> 04:59:24,549 BETWEEN ORGANIZATIONS TO SHARE 8677 04:59:24,549 --> 04:59:25,716 THE DATA IN THE FIRST PLACE AND 8678 04:59:25,716 --> 04:59:27,718 THE LACK OF STANDARDIZATION 8679 04:59:27,718 --> 04:59:32,657 AROUND THOSE CREATED VERY LARGE 8680 04:59:32,657 --> 04:59:35,593 BUREAUCRATIC BARRIERS TO RAPIDLY 8681 04:59:35,593 --> 04:59:37,495 DEPLOYING, ALL OF WHICH, THOUGH, 8682 04:59:37,495 --> 04:59:39,997 WERE EVENTUALLY OVERCOME, AND AT 8683 04:59:39,997 --> 04:59:42,300 THIS POINT, AT LEAST THE AI 8684 04:59:42,300 --> 04:59:44,168 READY PROJECT, WHICH I'M MOST 8685 04:59:44,168 --> 04:59:45,570 FAMILIAR WITH, IS ON TRACK TO 8686 04:59:45,570 --> 04:59:47,772 COMPLETE ITS 4,000 SUBJECT 8687 04:59:47,772 --> 04:59:52,243 MULTIMODAL DENSE DATASET 8688 04:59:52,243 --> 04:59:53,578 ENROLLMENT ON TIME BY THE END OF 8689 04:59:53,578 --> 04:59:54,112 THE FOURTH YEAR. 8690 04:59:54,112 --> 04:59:56,280 IN FACT, TO YOUR POINT, RAFAEL, 8691 04:59:56,280 --> 04:59:59,784 THE DATA SHARING IS A 8692 04:59:59,784 --> 05:00:01,619 REQUIREMENT OF THAT GRANT, AND 8693 05:00:01,619 --> 05:00:03,521 IF YOU GO TO AIREADY.ORG, I 8694 05:00:03,521 --> 05:00:05,323 THINK IT IS, YOU WILL SEE THE 8695 05:00:05,323 --> 05:00:05,690 CURRENT DATASET. 8696 05:00:05,690 --> 05:00:07,058 IT'S UP, YOU CAN DOWNLOAD IT, 8697 05:00:07,058 --> 05:00:08,793 AND IT'S WELL OVER A THOUSAND 8698 05:00:08,793 --> 05:00:10,795 SUBJECTS WITH COMPLETE DATASET 8699 05:00:10,795 --> 05:00:11,462 THAT ARE AVAILABLE FOR ANYONE 8700 05:00:11,462 --> 05:00:13,865 JUST LIKE ALL OF US OR ANY OF 8701 05:00:13,865 --> 05:00:15,600 THE OTHER LARGE DATASETS. 8702 05:00:15,600 --> 05:00:17,502 I THINK THIS IS SOMETHING NIH 8703 05:00:17,502 --> 05:00:19,337 UNIQUELY BRINGS TO THE FIELD, IS 8704 05:00:19,337 --> 05:00:20,338 THE ABILITY TO REQUIRE OPEN 8705 05:00:20,338 --> 05:00:22,607 SHARING OF DATA AS A REQUIREMENT 8706 05:00:22,607 --> 05:00:24,175 FOR FUNDING AND I THINK THAT'S 8707 05:00:24,175 --> 05:00:25,610 VERY, VERY POWERFUL HERE. 8708 05:00:25,610 --> 05:00:28,479 I ALSO WANT TO ADDRESS A LITTLE 8709 05:00:28,479 --> 05:00:31,849 BIT OF THE COMMENTS ABOUT DATA 8710 05:00:31,849 --> 05:00:32,583 INTEROPERABILITY. 8711 05:00:32,583 --> 05:00:34,152 I KNOW MIKE HAS THOUGHT ABOUT 8712 05:00:34,152 --> 05:00:39,290 THIS EXTENSIVELY AND ACTUALLY 8713 05:00:39,290 --> 05:00:40,391 PUBLISHED A VERY NICE EDITORIAL 8714 05:00:40,391 --> 05:00:42,260 IN OUR LITERATURE WHICH HE WROTE 8715 05:00:42,260 --> 05:00:44,662 IN COLLABORATION WITH A LEAD AT 8716 05:00:44,662 --> 05:00:48,799 THE FDA, AS WELL AS AT THE 8717 05:00:48,799 --> 05:00:49,333 NATIONAL -- OFFICE OF THE 8718 05:00:49,333 --> 05:00:50,668 NATIONAL COORDINATOR FOR HEALTH 8719 05:00:50,668 --> 05:00:52,970 INFORMATION TECHNOLOGY. 8720 05:00:52,970 --> 05:00:55,206 AND THAT LATTER GROUP ACTUALLY 8721 05:00:55,206 --> 05:00:56,541 EXISTS TO DRIVE DATA 8722 05:00:56,541 --> 05:00:58,176 HARMONIZATION IN THE CLINICAL 8723 05:00:58,176 --> 05:00:59,477 SPHERE, AND I WOULD STRONGLY 8724 05:00:59,477 --> 05:01:00,745 RECOMMEND THAT THEY HAVE A SEAT 8725 05:01:00,745 --> 05:01:02,446 AT THE TABLE AS YOU'RE DESIGNING 8726 05:01:02,446 --> 05:01:04,282 THESE PROGRAMS. 8727 05:01:04,282 --> 05:01:07,351 YOU KNOW, DICOM IS A STANDARD, 8728 05:01:07,351 --> 05:01:09,120 IT'S OUT THERE, IT IS VOLUNTARY, 8729 05:01:09,120 --> 05:01:13,724 AND AS WE ALL KNOW, THERE ARE 8730 05:01:13,724 --> 05:01:16,427 VENDORS WHO SUBSCRIBE AND THERE 8731 05:01:16,427 --> 05:01:21,432 ARE VENDORS THAT SAY THEY 8732 05:01:21,432 --> 05:01:23,734 SUBSCRIBE TO DICOM. 8733 05:01:23,734 --> 05:01:25,136 WERE IF IT'S GOING TO BE USEFUL 8734 05:01:25,136 --> 05:01:26,671 FOR PREDICTION, YOU WILL NEED TO 8735 05:01:26,671 --> 05:01:29,240 BE IN THE DICOM SPACE TO 8736 05:01:29,240 --> 05:01:30,174 PARTICIPATE AND I REALLY 8737 05:01:30,174 --> 05:01:32,677 ENCOURAGE YOU TO LEVERAGE THAT 8738 05:01:32,677 --> 05:01:34,445 OPPORTUNITY TO TRY TO BRING 8739 05:01:34,445 --> 05:01:36,214 VENDORS TO FINALLY COMPLYING SO 8740 05:01:36,214 --> 05:01:39,584 THAT THEIR DATA IS INTEROPERABLE 8741 05:01:39,584 --> 05:01:41,219 BETWEEN SITES. 8742 05:01:41,219 --> 05:01:43,654 FINALLY THE QUESTION IS, IT IS 8743 05:01:43,654 --> 05:01:45,056 UNCLEAR FROM THE PRESENTATION 8744 05:01:45,056 --> 05:01:47,258 WHAT THE POLICY IS GOING TO BE 8745 05:01:47,258 --> 05:01:50,561 ON THE IP THAT ARISES FROM THIS. 8746 05:01:50,561 --> 05:01:52,663 SO YOU HAVE A VERY LARGE DATASET 8747 05:01:52,663 --> 05:01:54,532 OR DATASETS THAT COME OUT OF 8748 05:01:54,532 --> 05:01:55,933 THIS, EXTREMELY RICH, PRESUMABLY 8749 05:01:55,933 --> 05:01:57,268 THE COMMUNITY WILL BE ABLE TO 8750 05:01:57,268 --> 05:02:00,838 MINE THIS FOR IDEAS. 8751 05:02:00,838 --> 05:02:02,907 WHAT WILL BE THE POLICY IN TERMS 8752 05:02:02,907 --> 05:02:04,642 OF PROTECTION OF THAT IP, 8753 05:02:04,642 --> 05:02:05,743 BAUER'S AS OTHERS HAVE 8754 05:02:05,743 --> 05:02:07,178 MENTIONED, THERE IS A HUGE 8755 05:02:07,178 --> 05:02:09,013 INTEREST IN THIS IN THE 8756 05:02:09,013 --> 05:02:12,650 COMMERCIAL SPACE, AND TO WOULD 8757 05:02:12,650 --> 05:02:13,851 BE HIGHLY DESIRABLE FOR THE WORK 8758 05:02:13,851 --> 05:02:15,286 THAT COMES OUT OF THIS PROJECT 8759 05:02:15,286 --> 05:02:17,288 TO BE ABLE TO MAKE TO THE 8760 05:02:17,288 --> 05:02:22,893 PUBLIC. 8761 05:02:22,893 --> 05:02:25,830 >> MIKE, MAYBE I CAN JUST JUMP 8762 05:02:25,830 --> 05:02:28,032 IN ON THE IP ISSUES. 8763 05:02:28,032 --> 05:02:32,303 WE DON'T SEE ANY SPECIFIC AT THE 8764 05:02:32,303 --> 05:02:33,638 BEGINNING KIND OF AT THE OUTSET 8765 05:02:33,638 --> 05:02:35,273 IN THE ABSENCE OF HAVING SEEN 8766 05:02:35,273 --> 05:02:39,210 ANY PROPOSALS COME. 8767 05:02:39,210 --> 05:02:42,480 DEVIATIONS FROM OUR NORMAL IP 8768 05:02:42,480 --> 05:02:42,747 POLICIES. 8769 05:02:42,747 --> 05:02:48,619 IN FACT, WE WANT TO -- WE NEED 8770 05:02:48,619 --> 05:02:50,688 TO ENCOURAGE IP AND 8771 05:02:50,688 --> 05:02:51,522 COMMERCIALIZATION IS PROBABLY 8772 05:02:51,522 --> 05:02:53,591 OUR BIGGEST MECHANISM OF 8773 05:02:53,591 --> 05:02:57,595 DISSEMINATION, BUT THERE'S ALSO 8774 05:02:57,595 --> 05:03:00,831 A KIND OF CONCURRENT MOVEMENT 8775 05:03:00,831 --> 05:03:03,067 TOWARDS OPEN SCIENCE AND 8776 05:03:03,067 --> 05:03:05,870 ALGORITHMS THAT ARE WIDELY 8777 05:03:05,870 --> 05:03:08,706 DISTRIBUTED AND VALIDATED IN A 8778 05:03:08,706 --> 05:03:09,940 COMMUNITY SENSE, SO WE'LL JUST 8779 05:03:09,940 --> 05:03:11,876 HAVE TO SEE HOW OUR COMMUNITY IS 8780 05:03:11,876 --> 05:03:13,311 RESPONDING TO THIS. 8781 05:03:13,311 --> 05:03:14,679 YOU KNOW, MUCH OF WHAT I DO IN 8782 05:03:14,679 --> 05:03:17,515 TERMS OF DEVICE DEVELOPMENT, AND 8783 05:03:17,515 --> 05:03:21,719 I STILL HAVE A LAB AND WE DO 8784 05:03:21,719 --> 05:03:24,722 DEVICES AND WE MAKE THE RAW DATA 8785 05:03:24,722 --> 05:03:28,693 FROM THE DEVICE AVAILABLE TO OUR 8786 05:03:28,693 --> 05:03:30,361 ENTIRE COMMUNITY. 8787 05:03:30,361 --> 05:03:31,462 WE PUBLISH THE ALGORITHMS ON 8788 05:03:31,462 --> 05:03:31,896 GITHUB. 8789 05:03:31,896 --> 05:03:33,197 THIS IS A VERY STRONG MOVEMENT 8790 05:03:33,197 --> 05:03:35,499 WITHIN THE DEVICE AND TECHNOLOGY 8791 05:03:35,499 --> 05:03:37,134 DEVELOPMENT COMMUNITY. 8792 05:03:37,134 --> 05:03:40,738 WE PUBLISH ENTIRELY BILLS OF 8793 05:03:40,738 --> 05:03:42,273 MATERIALS SO PEOPLE CAN BUILD 8794 05:03:42,273 --> 05:03:47,345 THE SAME DEVICE OR DEVIATIONS OF 8795 05:03:47,345 --> 05:03:47,678 IT. 8796 05:03:47,678 --> 05:03:49,447 SO THIS IS QUITE A POWERFUL 8797 05:03:49,447 --> 05:03:49,780 MOVEMENT. 8798 05:03:49,780 --> 05:03:50,948 WE DON'T KNOW EXACTLY WHERE ALL 8799 05:03:50,948 --> 05:03:52,216 OF THIS IS GOING TO GO. 8800 05:03:52,216 --> 05:03:53,551 WE'RE GOING TO SEE PROBABLY A 8801 05:03:53,551 --> 05:03:54,852 LITTLE BIT OF ALL OF THE ABOVE, 8802 05:03:54,852 --> 05:03:56,153 BUT OUR MAIN PASSION IS TO BE 8803 05:03:56,153 --> 05:03:58,055 ABLE TO GET THIS TO PATIENTS, 8804 05:03:58,055 --> 05:04:00,524 AND TO BE ABLE TO MOVE AND 8805 05:04:00,524 --> 05:04:04,362 ACCELERATE WHAT WE KNOW ARE 8806 05:04:04,362 --> 05:04:05,029 FABULOUS DISCOVERIES AND NEW 8807 05:04:05,029 --> 05:04:06,530 INSIGHTS THAT ARE HAPPENING ALL 8808 05:04:06,530 --> 05:04:07,965 ACROSS THE COUNTRY, BUT PATIENTS 8809 05:04:07,965 --> 05:04:12,002 ARE STILL GETTING THE TWO-LINE 8810 05:04:12,002 --> 05:04:13,104 IMPRESSION FROM THE RADIOLOGY 8811 05:04:13,104 --> 05:04:14,205 REPORT. 8812 05:04:14,205 --> 05:04:16,707 SO I WISH I HAD AN UP FRONT 8813 05:04:16,707 --> 05:04:18,242 ANSWER TO ALL THIS, BUT IT'S 8814 05:04:18,242 --> 05:04:22,012 GOING TO BE AN EVOLVING STORY. 8815 05:04:22,012 --> 05:04:22,213 MIKE? 8816 05:04:22,213 --> 05:04:26,717 >> YOU KNOW, THANK YOU FOR YOUR 8817 05:04:26,717 --> 05:04:28,819 COMMENTS, RUSS. 8818 05:04:28,819 --> 05:04:30,354 WHEN THE HANDS STARTED GOING UP, 8819 05:04:30,354 --> 05:04:32,189 I DIDN'T SEE YOURS RIGHT AWAY, I 8820 05:04:32,189 --> 05:04:33,524 WONDERED IF SOMETHING'S WRONG, 8821 05:04:33,524 --> 05:04:40,197 SO GLAD TO HEAR FROM YOU NOW. 8822 05:04:40,197 --> 05:04:41,732 I AGREE WITH EVERY SINGLE THING 8823 05:04:41,732 --> 05:04:43,067 IE. JUST GOING TO HIGHLIGHT ONE 8824 05:04:43,067 --> 05:04:45,136 THING THAT BRUCE DID NOT TALK 8825 05:04:45,136 --> 05:04:47,104 ABOUT, WORKING ACROSS AGENCIES 8826 05:04:47,104 --> 05:04:48,372 AND THIS PROJECT THAT WE WORKED 8827 05:04:48,372 --> 05:04:52,777 ON WITH THE FDA AND WITH THE 8828 05:04:52,777 --> 05:04:54,011 OMC/ASTP, THE ASSISTANT 8829 05:04:54,011 --> 05:04:56,347 SECRETARY FOR TECHNOLOGY POLICY. 8830 05:04:56,347 --> 05:04:59,183 I WOULD JUST UNDERSCORE, RUSS, 8831 05:04:59,183 --> 05:05:01,585 WHAT YOU SAID, THAT IN A WORLD 8832 05:05:01,585 --> 05:05:04,021 WHERE THERE ARE STICKS AND 8833 05:05:04,021 --> 05:05:05,189 CARROTS, I THINK THERE'S A ROLE 8834 05:05:05,189 --> 05:05:07,158 FOR EACH OF THEM AND WE VIEW 8835 05:05:07,158 --> 05:05:09,393 THIS AS A CARROT. 8836 05:05:09,393 --> 05:05:10,594 WE TRIED TO COME UP WITH RULES 8837 05:05:10,594 --> 05:05:13,297 WHEN THE FIELD WASN'T MOVING IN 8838 05:05:13,297 --> 05:05:14,765 A CERTAIN DIRECTION AFTER ABOUT 8839 05:05:14,765 --> 05:05:16,300 THE 15 TO 20 YEARS THAT I'VE 8840 05:05:16,300 --> 05:05:17,635 BEEN INVOLVED WITH IT, WHAT CAN 8841 05:05:17,635 --> 05:05:19,069 WE DO IN TERMS OF STICKS TO MOVE 8842 05:05:19,069 --> 05:05:19,403 THAT. 8843 05:05:19,403 --> 05:05:21,372 THOSE WERE THE ONES THAT WE 8844 05:05:21,372 --> 05:05:24,375 CREATED, SO TOTALLY AGREE WE 8845 05:05:24,375 --> 05:05:26,343 COULD DO SOME STUFF WITH THEM 8846 05:05:26,343 --> 05:05:27,878 INVOLVING INTRAOPERABILITY, AND 8847 05:05:27,878 --> 05:05:28,946 REALLY APPRECIATE YOUR RAISING 8848 05:05:28,946 --> 05:05:32,817 THAT. 8849 05:05:32,817 --> 05:05:33,083 >> GREAT. 8850 05:05:33,083 --> 05:05:34,118 OKAY, THANK YOU. 8851 05:05:34,118 --> 05:05:35,786 OUR LAST COUNCILMEMBER WITH HER 8852 05:05:35,786 --> 05:05:36,854 HAND RAISED IS JEAN. 8853 05:05:36,854 --> 05:05:38,756 PLEASE GO AHEAD. 8854 05:05:38,756 --> 05:05:40,691 >> THIS IS GOING TO BE QUICK, I 8855 05:05:40,691 --> 05:05:40,925 HOPE. 8856 05:05:40,925 --> 05:05:42,993 I AM REALLY EXCITED ABOUT THIS 8857 05:05:42,993 --> 05:05:43,894 PROJECT. 8858 05:05:43,894 --> 05:05:45,196 OBVIOUSLY I DO IMAGING AND I DO 8859 05:05:45,196 --> 05:05:46,831 AI, THE COMBINATION IS AMAZING, 8860 05:05:46,831 --> 05:05:51,335 AND I'M SO EXCITED ABOUT THE 8861 05:05:51,335 --> 05:05:52,770 POSSIBILITIES. 8862 05:05:52,770 --> 05:05:56,373 YOU HAVE FUNDED --MAN BY DAVID 8863 05:05:56,373 --> 05:05:57,374 KENNEDY WHO ACTUALLY DID A LOT 8864 05:05:57,374 --> 05:05:58,676 OF THIS WORK IN TERMS OF 8865 05:05:58,676 --> 05:05:59,610 BUILDING TOOLS FOR THE 8866 05:05:59,610 --> 05:06:01,579 INTEROPERABILITY AND I THINK 8867 05:06:01,579 --> 05:06:03,781 OBVIOUSLY IS NIH FUNDED BY YOU. 8868 05:06:03,781 --> 05:06:04,448 I'M THINKING A LOT OF THOSE 8869 05:06:04,448 --> 05:06:05,316 TOOLS CAN BE USED HERE. 8870 05:06:05,316 --> 05:06:07,618 I WANTED TO GO BACK TO WHAT 8871 05:06:07,618 --> 05:06:09,086 LINDA SAID. 8872 05:06:09,086 --> 05:06:09,753 IT'S SOMETIMES REALLY DIFFICULT 8873 05:06:09,753 --> 05:06:10,754 IN IMAGING. 8874 05:06:10,754 --> 05:06:14,225 IT DEPENDS ON WHAT MACHINE, THE 8875 05:06:14,225 --> 05:06:15,526 STRENGTH OF THE MACHINE, WHETHER 8876 05:06:15,526 --> 05:06:17,027 OR NOT IT'S A PARTICULAR KIND OF 8877 05:06:17,027 --> 05:06:18,329 SCAN OR WHAT KIND OF SCANNING 8878 05:06:18,329 --> 05:06:19,396 YOU DID. 8879 05:06:19,396 --> 05:06:21,065 THERE'S A LOT OF WORK THERE TO 8880 05:06:21,065 --> 05:06:22,867 BRING THOSE PIECES TOGETHER. 8881 05:06:22,867 --> 05:06:24,602 I TOTALLY BELIEVE THAT THE 8882 05:06:24,602 --> 05:06:25,803 INTEGRATION WOULD LEAD TO 8883 05:06:25,803 --> 05:06:26,904 INNOVATION AND HUGE IMPACTS. 8884 05:06:26,904 --> 05:06:28,606 SO I'M IN, I JUST THINK A LOT OF 8885 05:06:28,606 --> 05:06:29,707 WHAT WE'RE SAYING IS THERE'S A 8886 05:06:29,707 --> 05:06:31,675 LOT OF WORK HERE PROBABLY MORE 8887 05:06:31,675 --> 05:06:33,811 THAN WE THINK ABOUT RIGHT NOW, 8888 05:06:33,811 --> 05:06:35,846 THAT CANNOT STOP US, BUT I THINK 8889 05:06:35,846 --> 05:06:39,016 WHEN I SAW YOU HAD MOSTLY MONEY 8890 05:06:39,016 --> 05:06:41,352 TOWARDS GOING FROM THE DATA TO 8891 05:06:41,352 --> 05:06:43,420 THE CLINIC, I THINK THAT MAY 8892 05:06:43,420 --> 05:06:45,389 TAKE MORAL WORK THAN WE THINK, 8893 05:06:45,389 --> 05:06:48,025 AND I WOULD REALLY WANT TO PUT A 8894 05:06:48,025 --> 05:06:49,593 LOT OF IT INTO THE INTEGRATION 8895 05:06:49,593 --> 05:06:50,127 PART. 8896 05:06:50,127 --> 05:06:51,662 ONCE WE'RE DOING GOOD 8897 05:06:51,662 --> 05:06:53,197 INTEGRATION AND WE HAVE THE 8898 05:06:53,197 --> 05:06:55,199 ALGORITHMS TO REALLY HELP US, 8899 05:06:55,199 --> 05:06:57,701 ESPECIALLY WITH PREDICTION, I'M 8900 05:06:57,701 --> 05:06:59,904 REALLY EXCITED ABOUT PREDICTION. 8901 05:06:59,904 --> 05:07:06,377 IT'S LOWIT'S HOW WE COULD PREDIO 8902 05:07:06,377 --> 05:07:07,878 WILL AND WHO WILL NOT GET A 8903 05:07:07,878 --> 05:07:09,213 PARTICULAR DISEASE. 8904 05:07:09,213 --> 05:07:09,847 I THINK THERE'S A LOT THERE. 8905 05:07:09,847 --> 05:07:11,615 I THINK IT CAN BLOW UP SCIENCE 8906 05:07:11,615 --> 05:07:12,816 AND WHAT WE THINK ABOUT IT, I 8907 05:07:12,816 --> 05:07:14,051 THINK IT'S GOING TO CHANGE AND 8908 05:07:14,051 --> 05:07:15,386 TRANSFORM THIS WHOLE ECOSYSTEM, 8909 05:07:15,386 --> 05:07:18,556 BUT THE INTEGRATION PART, I FEEL 8910 05:07:18,556 --> 05:07:20,190 THERE'S PROBABLY GOING TO NEED 8911 05:07:20,190 --> 05:07:24,995 TO BE MORE -- HAVING A 8912 05:07:24,995 --> 05:07:26,363 COORDINATED SITE WHICH I'M NOT 8913 05:07:26,363 --> 05:07:27,998 SURE I SAW YOU HAD IN THERE, BUT 8914 05:07:27,998 --> 05:07:29,400 HOW WE'LL BRING ALL THAT DATA 8915 05:07:29,400 --> 05:07:31,936 TOGETHER SO EVERYONE WILL BE 8916 05:07:31,936 --> 05:07:32,536 LEARNING AT THE SAME TIME FROM 8917 05:07:32,536 --> 05:07:34,705 EACH OARL AS OPPOSED TO 8918 05:07:34,705 --> 05:07:36,240 REBUILDING THE WHEEL OVER AN 8919 05:07:36,240 --> 05:07:39,143 OVER. 8920 05:07:39,143 --> 05:07:41,278 >> THANK YOU VERY MUCH, JEAN. 8921 05:07:41,278 --> 05:07:44,448 >> I THINK WE'RE BOTH IN -- IS 8922 05:07:44,448 --> 05:07:46,750 GE WHAT WOULD YOU SAY, VIOLENT 8923 05:07:46,750 --> 05:07:48,185 AGREEMENT ABOUT THAT. 8924 05:07:48,185 --> 05:07:50,287 AND YOU KNOW, THAT'S PART OF, I 8925 05:07:50,287 --> 05:07:52,556 THINK, THE BRILLIANCE OF OUR 8926 05:07:52,556 --> 05:07:54,658 COLLEAGUES WHO SORT OF 8927 05:07:54,658 --> 05:07:56,427 STRUCTURED ALL OF THESE ELEMENTS 8928 05:07:56,427 --> 05:07:59,396 TO FUND AND THE OVERALL PLAN, 8929 05:07:59,396 --> 05:08:00,831 WHICH SPENDS AN ENORMOUS AMOUNT 8930 05:08:00,831 --> 05:08:04,134 OF TIME AND RESOURCES MAKING 8931 05:08:04,134 --> 05:08:06,203 SURE THAT THE ALGORITHMS ARE 8932 05:08:06,203 --> 05:08:07,404 THOUGHTFULLY DEVELOPED AND 8933 05:08:07,404 --> 05:08:11,775 VALIDATED AND THEN CAN 8934 05:08:11,775 --> 05:08:13,677 POTENTIALLY PIGGY BACK ON TO 8935 05:08:13,677 --> 05:08:15,846 ONGOING STUDIES, THESE ANCILLARY 8936 05:08:15,846 --> 05:08:17,982 STUDIES THAT ARE HAPPENING 8937 05:08:17,982 --> 05:08:18,482 EVERYWHERE. 8938 05:08:18,482 --> 05:08:21,051 YOU KNOW, FROM ECOG AKRON WHICH 8939 05:08:21,051 --> 05:08:25,422 IS SORT OF THE BIG BEAST AT THE 8940 05:08:25,422 --> 05:08:30,661 NIH TO INDUSTRY SPONSORED DRUG 8941 05:08:30,661 --> 05:08:32,196 TRIALS WHERE THEY HAVE 8942 05:08:32,196 --> 05:08:32,696 LONGITUDINAL IMAGING FOR 8943 05:08:32,696 --> 05:08:33,764 PATIENTS BUT AGAIN, NO ONE 8944 05:08:33,764 --> 05:08:36,734 REALLY LOOKS AT THE IMAGES, THEY 8945 05:08:36,734 --> 05:08:38,535 JUST SAY A VERY BRIEF IMPRESSION 8946 05:08:38,535 --> 05:08:43,674 OF A FEW KILOBYTES, AND -- OR 8947 05:08:43,674 --> 05:08:45,643 KILOBITS, AND SO WE'RE HOPING 8948 05:08:45,643 --> 05:08:47,878 THE COMMUNITY REALLY JUST TAKES 8949 05:08:47,878 --> 05:08:49,913 ADVANTAGE OF THOSE THINGS, THE 8950 05:08:49,913 --> 05:08:51,448 ENORMOUS ONGOING EFFORT AND THE 8951 05:08:51,448 --> 05:08:52,449 ENORMOUS RESOURCES THAT WE'RE 8952 05:08:52,449 --> 05:08:54,885 GOING TO PUT IN, IN ADDITION TO 8953 05:08:54,885 --> 05:08:55,953 THE FUNDING, BUT THE EXPERTISE 8954 05:08:55,953 --> 05:08:57,354 THAT ALL OF US HAVE DEVELOPED 8955 05:08:57,354 --> 05:08:59,857 OVER THE LAST SEVERAL YEARS. 8956 05:08:59,857 --> 05:09:02,359 TO REALLY BRING PEOPLE TOGETHER, 8957 05:09:02,359 --> 05:09:04,328 AND TO ACCELERATE THE 8958 05:09:04,328 --> 05:09:05,095 COMMERCIALIZATION AND THE 8959 05:09:05,095 --> 05:09:10,401 TRANSLATION OF THESE APPROACHES. 8960 05:09:10,401 --> 05:09:10,801 >> THANK YOU. 8961 05:09:10,801 --> 05:09:13,570 I'D ALSO JUST LIKE TO HIGHLIGHT 8962 05:09:13,570 --> 05:09:16,407 THAT CAROLYN HAS PUT SEVERAL 8963 05:09:16,407 --> 05:09:20,344 COMMENTS IN THE CHAT ABOUT 8964 05:09:20,344 --> 05:09:22,980 HAVING EXISTING MOUs WITH FDA 8965 05:09:22,980 --> 05:09:25,716 TO SPECIFICALLY GET EARLY 8966 05:09:25,716 --> 05:09:27,685 FEEDBACK FROM THE AGENCY, SO I 8967 05:09:27,685 --> 05:09:28,852 THINK THAT'S AN EXAMPLE WITH 8968 05:09:28,852 --> 05:09:30,020 RESPECT TO SORT OF THE 8969 05:09:30,020 --> 05:09:31,455 REGULATORY PIECE WHERE WE ARE 8970 05:09:31,455 --> 05:09:35,392 ABLE TO LEARN FROM EXISTING 8971 05:09:35,392 --> 05:09:37,728 PROGRAMS BUT ALSO WITH THE DATA 8972 05:09:37,728 --> 05:09:41,131 SHARING REQUIREMENTS HAVING 8973 05:09:41,131 --> 05:09:41,965 THOSE CONSIDERATIONS BE BUILT 8974 05:09:41,965 --> 05:09:46,870 INTO THE NOFO AND HAVE THOSE 8975 05:09:46,870 --> 05:09:48,072 BE -- THE AWARD SELECTION AND 8976 05:09:48,072 --> 05:09:49,239 FUNDING BE SPECIFICALLY TIED TO 8977 05:09:49,239 --> 05:09:52,443 THOSE REQUIREMENTS AS WELL. 8978 05:09:52,443 --> 05:09:54,311 SO DEFINITELY REALLY, REALLY 8979 05:09:54,311 --> 05:09:54,912 APPRECIATE ALL OF THE FEEDBACK 8980 05:09:54,912 --> 05:09:57,614 THAT'S BEING PROVIDED HERE, AND 8981 05:09:57,614 --> 05:10:00,484 THAT WILL BE -- IF THIS CONCEPT 8982 05:10:00,484 --> 05:10:02,486 IS APPROVED, THAT WILL 8983 05:10:02,486 --> 05:10:03,987 ABSOLUTELY BE INTEGRATED INTO 8984 05:10:03,987 --> 05:10:05,756 HOW THE NOFOs ARE WRITTEN AND 8985 05:10:05,756 --> 05:10:08,125 HOW THE PROGRAM IS STRUCTURED. 8986 05:10:08,125 --> 05:10:08,992 OKAY. 8987 05:10:08,992 --> 05:10:12,496 I THINK THAT CLOSES THE 8988 05:10:12,496 --> 05:10:13,831 DISCUSSION HERE. 8989 05:10:13,831 --> 05:10:14,898 FRANZISKA, I'LL TURN IT OVER TO 8990 05:10:14,898 --> 05:10:15,065 YOU. 8991 05:10:15,065 --> 05:10:15,699 >> OKAY. 8992 05:10:15,699 --> 05:10:17,701 SO THEN THAT BRINGS US TO THE 8993 05:10:17,701 --> 05:10:18,469 LAST VOTE FOR TODAY. 8994 05:10:18,469 --> 05:10:22,406 I'M GOING TO CALL FOR A VOTE 8995 05:10:22,406 --> 05:10:22,606 ON -- 8996 05:10:22,606 --> 05:10:24,742 >> BEFORE WE VOTE, SORRY, I WAS 8997 05:10:24,742 --> 05:10:25,943 TRYING TO UNMUTE. 8998 05:10:25,943 --> 05:10:26,910 CAN YOU CLARIFY A LITTLE BIT 8999 05:10:26,910 --> 05:10:29,780 MORE ABOUT THAT LAST COMMENT? 9000 05:10:29,780 --> 05:10:32,316 WE'RE VOTING FOR THE CONCEPT TO 9001 05:10:32,316 --> 05:10:35,953 BE APPROVED AND THEN IS THE 9002 05:10:35,953 --> 05:10:38,288 FUNDING THEN GUARANTEED OR IS 9003 05:10:38,288 --> 05:10:40,758 THERE A NEXT DISCUSSION ABOUT 9004 05:10:40,758 --> 05:10:40,924 IT? 9005 05:10:40,924 --> 05:10:43,594 >> LET ME TRY TO EXPLAIN HOW 9006 05:10:43,594 --> 05:10:44,795 THAT NORMALLY WORKS. 9007 05:10:44,795 --> 05:10:48,198 IF A CONCEPT IS APPROVED, THAT 9008 05:10:48,198 --> 05:10:52,136 GIVES US THE GO-AHEAD TO MOVE 9009 05:10:52,136 --> 05:10:56,106 FORWARD IF FUNDING IS AVAILABLE, 9010 05:10:56,106 --> 05:10:58,075 IF THE CIRCUMSTANCES ARE CORRECT 9011 05:10:58,075 --> 05:11:03,147 AND IF IF EVERYBODY'S READY TOO 9012 05:11:03,147 --> 05:11:04,248 IT, THAT DOES NOT GUARANTEE IT 9013 05:11:04,248 --> 05:11:04,882 GOES FORWARD. 9014 05:11:04,882 --> 05:11:06,416 OF COURSE AN IMPORTANT PART IS 9015 05:11:06,416 --> 05:11:07,417 THE ENTIRE DISCUSSION THAT WE 9016 05:11:07,417 --> 05:11:09,286 HEARD TODAY, PROGRAM STAFF WILL 9017 05:11:09,286 --> 05:11:11,922 TAKE ALL THOSE COMMENTS INTO 9018 05:11:11,922 --> 05:11:15,526 CONSIDERATION AND BUILD THOSE IN 9019 05:11:15,526 --> 05:11:17,728 WHICH THEN HAS AN INFLUENCE ON 9020 05:11:17,728 --> 05:11:20,597 WHAT YOUR QUESTION WAS. 9021 05:11:20,597 --> 05:11:21,598 WHAT WILL THE BUDGET BE? 9022 05:11:21,598 --> 05:11:24,768 WELL, IF WE BUILD MUCH -- A 9023 05:11:24,768 --> 05:11:25,702 BIGGER CASSELL, THEN OF COURSE 9024 05:11:25,702 --> 05:11:32,976 CASTLE, THE COSTS WILL BEMUCH HE 9025 05:11:32,976 --> 05:11:33,177 MONEY. 9026 05:11:33,177 --> 05:11:33,844 YOU UNDERSTAND WHAT I'M TRYING 9027 05:11:33,844 --> 05:11:34,578 TO SAY. 9028 05:11:34,578 --> 05:11:36,013 DID THAT ANSWER YOUR QUESTION, 9029 05:11:36,013 --> 05:11:36,246 RAFAEL? 9030 05:11:36,246 --> 05:11:37,414 >> ABSOLUTELY. 9031 05:11:37,414 --> 05:11:37,581 YEP. 9032 05:11:37,581 --> 05:11:39,016 >> EXCELLENT. 9033 05:11:39,016 --> 05:11:41,985 OKAY. 9034 05:11:41,985 --> 05:11:42,853 SO WE STOP THEN. 9035 05:11:42,853 --> 05:11:44,621 I'M GOING TO CALL FOR A MOTION. 9036 05:11:44,621 --> 05:11:45,823 A MOTION FOR APPROVAL OF THE 9037 05:11:45,823 --> 05:11:48,759 COMMON FUND CONCEPT CLEARANCE 9038 05:11:48,759 --> 05:11:53,030 ENTITLED PRECISION MEDICINE WITH 9039 05:11:53,030 --> 05:11:55,799 AI, INTEGRATING IMAGING WITH 9040 05:11:55,799 --> 05:11:57,568 MULTIMODAL DATA, PRIME AI 9041 05:11:57,568 --> 05:11:57,868 PROGRAM. 9042 05:11:57,868 --> 05:11:58,969 IS THERE SUCH A MOTION? 9043 05:11:58,969 --> 05:12:00,237 I SEE SO MOVED. 9044 05:12:00,237 --> 05:12:01,972 I SEE SECOND. 9045 05:12:01,972 --> 05:12:05,142 ANY ADDITIONAL DISCUSSION AT 9046 05:12:05,142 --> 05:12:08,212 THIS POINT? 9047 05:12:08,212 --> 05:12:09,179 I SEE NO HANDS. 9048 05:12:09,179 --> 05:12:11,481 I SEE NO CHAT INFO. 9049 05:12:11,481 --> 05:12:13,917 WE ARE DOING HOPEFULLY THE LAST 9050 05:12:13,917 --> 05:12:16,653 TIME OUR HAND RAISING VOTES. 9051 05:12:16,653 --> 05:12:18,288 CHRISTINA, PLEASE GO AHEAD. 9052 05:12:18,288 --> 05:12:21,225 >> THANK YOU, DR. GRIEDER. 9053 05:12:21,225 --> 05:12:22,726 AS A REMINDER, ONLY 9054 05:12:22,726 --> 05:12:23,493 COUNCILMEMBERS SHOULD 9055 05:12:23,493 --> 05:12:24,294 PARTICIPATE. 9056 05:12:24,294 --> 05:12:26,363 THIS IS A VOTE ON THE MOTION FOR 9057 05:12:26,363 --> 05:12:31,301 APPROVAL OF THE PROPOSED OSC 9058 05:12:31,301 --> 05:12:32,703 CONCEPT CLEARANCE. 9059 05:12:32,703 --> 05:12:34,171 PLEASE RAISE YOUR HAND NOW TO 9060 05:12:34,171 --> 05:12:42,045 VOTE AYE. 9061 05:12:42,045 --> 05:12:42,713 THANK YOU. 9062 05:12:42,713 --> 05:12:50,687 I SEE 12 HAN 12 HANDS VOATING A. 9063 05:12:50,687 --> 05:12:51,788 VOTING AYE. 9064 05:12:51,788 --> 05:12:59,429 PLEASE LOWER YOUR HANDS. 9065 05:12:59,429 --> 05:13:01,398 PLEASE LOWER YOUR HANDS, ONE 9066 05:13:01,398 --> 05:13:01,598 MORE. 9067 05:13:01,598 --> 05:13:01,865 THANK YOU. 9068 05:13:01,865 --> 05:13:02,199 ALL RIGHT. 9069 05:13:02,199 --> 05:13:03,634 NEXT PLEASE RAISE YOUR HAND TO 9070 05:13:03,634 --> 05:13:13,810 VOTE NAY. 9071 05:13:14,645 --> 05:13:15,012 THANK YOU. 9072 05:13:15,012 --> 05:13:20,083 I SEE TWO HANDS. 9073 05:13:20,083 --> 05:13:20,951 PLEASE GO AHEAD AND LOWER THOSE 9074 05:13:20,951 --> 05:13:23,587 HANDS. 9075 05:13:23,587 --> 05:13:27,291 THANK YOU SO MUCH. 9076 05:13:27,291 --> 05:13:28,725 UP NEXT, PLEASE RAISE YOUR HAND 9077 05:13:28,725 --> 05:13:35,632 TO VOTE ABSTENTION. 9078 05:13:35,632 --> 05:13:37,067 NOT SEEING ANY HANDS, THIS 9079 05:13:37,067 --> 05:13:40,003 CONCLUDES THE VOTE. 9080 05:13:40,003 --> 05:13:41,838 THE MOTION AS STATED HAS PASSED. 9081 05:13:41,838 --> 05:13:45,208 >> THANK YOU, CHRISTINA. 9082 05:13:45,208 --> 05:13:45,842 GLEUSH BACK TO YOU. 9083 05:13:45,842 --> 05:13:47,811 >> THANK YOU ALL VERY MUCH. 9084 05:13:47,811 --> 05:13:53,250 SO THIS CONCLUDES THE CONCEPT 9085 05:13:53,250 --> 05:13:53,784 CLEARANCE PORTIONS OF OUR 9086 05:13:53,784 --> 05:13:54,251 AGENDA. 9087 05:13:54,251 --> 05:13:58,922 SO NOW I WANT TO PIVOT -- 9088 05:13:58,922 --> 05:14:00,691 DR. JOHNSON, DID YOU WANT TO SAY 9089 05:14:00,691 --> 05:14:00,958 SOMETHING? 9090 05:14:00,958 --> 05:14:01,992 >> YEAH, HI. 9091 05:14:01,992 --> 05:14:05,429 I JUST REALIZED, ARE WE GOING TO 9092 05:14:05,429 --> 05:14:08,999 HAVE A CHANCE TO DISCUSS DSI 9093 05:14:08,999 --> 05:14:09,232 AFRICA? 9094 05:14:09,232 --> 05:14:10,200 THAT WAS ON OUR SLATE. 9095 05:14:10,200 --> 05:14:11,635 DID THAT JUST GET TABLED OR WHAT 9096 05:14:11,635 --> 05:14:13,737 HAPPENED WITH THAT? 9097 05:14:13,737 --> 05:14:14,371 >> THAT IS CURRENTLY TABLED, SO 9098 05:14:14,371 --> 05:14:16,807 IT IS NOT ON THE AGENDA FOR THIS 9099 05:14:16,807 --> 05:14:18,008 MONTH'S MEETING. 9100 05:14:18,008 --> 05:14:20,444 IT IS UNDER CONSIDERATION STILL 9101 05:14:20,444 --> 05:14:21,478 FOR THE MAY COUNCIL MEETING. 9102 05:14:21,478 --> 05:14:22,245 >> OKAY. 9103 05:14:22,245 --> 05:14:23,013 GREAT. 9104 05:14:23,013 --> 05:14:25,549 OKAY. 9105 05:14:25,549 --> 05:14:33,824 >> SO THE NEXT THING WE WANT TO 9106 05:14:33,824 --> 05:14:35,058 ADDRESS QUICKLY, I KNOW WE'RE 9107 05:14:35,058 --> 05:14:35,926 OVER TIME AND I APPRECIATE ALL 9108 05:14:35,926 --> 05:14:39,396 OF YOU SPENDING A FEW EXTRA 9109 05:14:39,396 --> 05:14:41,164 MINUTES WITH US, BUT WE WANT TO 9110 05:14:41,164 --> 05:14:43,133 HAVE SOME REFLECTIONS FROM OUR 9111 05:14:43,133 --> 05:14:44,334 DEPARTING COUNCILMEMBERS. 9112 05:14:44,334 --> 05:14:47,037 SO I WANT TO TAKE A MOMENT TO 9113 05:14:47,037 --> 05:14:49,873 EXTEND MY SINCERE GRATITUDE, BUT 9114 05:14:49,873 --> 05:14:51,742 REALLY ON BEHALF OF ALL OF 9115 05:14:51,742 --> 05:14:54,011 DPCPSI AND ALL OF NIH TO OUR 9116 05:14:54,011 --> 05:14:55,345 DEPARTING MEMBERS. 9117 05:14:55,345 --> 05:14:57,080 SO YOUR THOUGHTFUL GUIDANCE HAS 9118 05:14:57,080 --> 05:14:58,982 REALLY PLAYED A VITAL ROLE IN 9119 05:14:58,982 --> 05:15:01,618 HELPING NIH NAVIGATE COMPLEX 9120 05:15:01,618 --> 05:15:03,487 HEALTH CHALLENGES AND ADVANCE 9121 05:15:03,487 --> 05:15:04,021 SCIENTIFIC DISCOVERY. 9122 05:15:04,021 --> 05:15:06,623 WE ARE REALLY TRULY FORTUNATE TO 9123 05:15:06,623 --> 05:15:08,592 HAVE SUCH A DEDICATED GROUP OF 9124 05:15:08,592 --> 05:15:10,761 LEADERS HELPING TO SHAPE THE 9125 05:15:10,761 --> 05:15:12,429 FUTURE OF BIOMEDICAL AND 9126 05:15:12,429 --> 05:15:15,165 BEHAVIORAL RESEARCH. 9127 05:15:15,165 --> 05:15:16,366 SO ONCE AGAIN THANK YOU SO MUCH 9128 05:15:16,366 --> 05:15:17,667 FOR YOUR SERVICE, YOUR EXPERTISE 9129 05:15:17,667 --> 05:15:19,603 AND YOUR UNWAVERING COMMITMENT 9130 05:15:19,603 --> 05:15:21,338 TO THE NIH MISSION. 9131 05:15:21,338 --> 05:15:23,073 SO WE WANT TO ENSURE THAT OUR 9132 05:15:23,073 --> 05:15:24,574 DEPARTING COUNCILMEMBERS HAVE 9133 05:15:24,574 --> 05:15:25,509 THE OPPORTUNITY TO SHARE THEIR 9134 05:15:25,509 --> 05:15:27,444 INSIGHTS AND LEAVE US WITH SOME 9135 05:15:27,444 --> 05:15:30,514 PARTING WISDOM, IF THEY SO 9136 05:15:30,514 --> 05:15:30,747 CHOOSE. 9137 05:15:30,747 --> 05:15:31,415 SO PLEASE FEEL FREE TO COME OFF 9138 05:15:31,415 --> 05:15:32,616 MUTE TO SHARE YOUR THOUGHTS. 9139 05:15:32,616 --> 05:15:36,119 I KNOW THAT ONE OF OUR DEPARTING 9140 05:15:36,119 --> 05:15:37,054 MEMBERS, KRISTIN ARDLIE, HAD TO 9141 05:15:37,054 --> 05:15:39,356 JUMP OFF ALREADY, BUT IF LINDA 9142 05:15:39,356 --> 05:15:42,893 OR KEVIN OR RHONDA OR SUSAN OR 9143 05:15:42,893 --> 05:15:44,861 ANNA MARIA WOULD LIKE TO SAY A 9144 05:15:44,861 --> 05:15:46,396 FEW WORDS, WE WOULD WELCOME THAT 9145 05:15:46,396 --> 05:15:47,697 FEEDBACK. 9146 05:15:47,697 --> 05:15:49,066 KEVIN, PLEASE GO AHEAD. 9147 05:15:49,066 --> 05:15:50,233 >> THANK YOU. 9148 05:15:50,233 --> 05:15:51,635 I HAD SOME PREPARED REMARKS, I 9149 05:15:51,635 --> 05:15:53,570 THOUGHT I WOULD SAVE THEM. 9150 05:15:53,570 --> 05:15:54,971 SO AS I STEP DOWN FROM THIS 9151 05:15:54,971 --> 05:15:56,173 REMARKABLE COMMITTEE, I WANT TO 9152 05:15:56,173 --> 05:15:57,507 TAKE A MOMENT TO REFLECT NOT 9153 05:15:57,507 --> 05:15:59,743 JUST ON OUR SHARED WORK, BUT ON 9154 05:15:59,743 --> 05:16:00,811 THE PRINCIPLES THAT HAVE 9155 05:16:00,811 --> 05:16:01,912 ANCHORED MY CAREER AND MY 9156 05:16:01,912 --> 05:16:02,679 SERVICE HERE. 9157 05:16:02,679 --> 05:16:04,448 I BELIEVE DEEPLY IN THE 9158 05:16:04,448 --> 05:16:05,315 SCIENTIFIC PROCESS. 9159 05:16:05,315 --> 05:16:08,385 NOT AS A RIGID PROTOCOL BUT AS A 9160 05:16:08,385 --> 05:16:10,520 DYNAMIC ENGINE FOR TRUTH, DRIVEN 9161 05:16:10,520 --> 05:16:12,055 BY CURIOSITY, DISCIPLINE, 9162 05:16:12,055 --> 05:16:13,590 SKEPTICISM, AND CREATIVITY. 9163 05:16:13,590 --> 05:16:16,259 AND I'VE COME TO APPRECIATE MORE 9164 05:16:16,259 --> 05:16:17,360 THAN EVER THAT MEANINGFUL 9165 05:16:17,360 --> 05:16:19,529 INNOVATION EMERGES WHEN PEOPLE, 9166 05:16:19,529 --> 05:16:20,730 PROCESS AND TECHNOLOGY ARE 9167 05:16:20,730 --> 05:16:22,299 ALIGNED WITH INTENTION. 9168 05:16:22,299 --> 05:16:23,433 IT'S FROM THAT VANTAGE POINT 9169 05:16:23,433 --> 05:16:25,168 THAT I FEEL COMPELLED TO EXPRESS 9170 05:16:25,168 --> 05:16:27,804 SOME CONCERNS ABOUT THE PACE AND 9171 05:16:27,804 --> 05:16:29,339 DIRECTION OF RECENT CHANGES AT 9172 05:16:29,339 --> 05:16:30,774 THE NIH, OFTEN FRAMED AS 9173 05:16:30,774 --> 05:16:31,775 PROGRESS. 9174 05:16:31,775 --> 05:16:33,076 PROGRESS IS ESSENTIAL. 9175 05:16:33,076 --> 05:16:35,512 BUT IT IS NOT SUMMON MULLS WITH 9176 05:16:35,512 --> 05:16:36,113 SPEED. 9177 05:16:36,113 --> 05:16:37,280 PEOPLE REMAIN AT THE HEART OF 9178 05:16:37,280 --> 05:16:37,714 SCIENCE. 9179 05:16:37,714 --> 05:16:39,783 OUR TRAINEES WHO DEPEND ON 9180 05:16:39,783 --> 05:16:41,918 STABLE MENTORSHIP STRUCTURES, 9181 05:16:41,918 --> 05:16:43,787 OUR COMMUNITIES WHO DESERVE 9182 05:16:43,787 --> 05:16:45,522 CLEAR, TRUSTWORTHY SCIENCE 9183 05:16:45,522 --> 05:16:46,957 COMMUNICATION, OUR POLICYMAKERS 9184 05:16:46,957 --> 05:16:49,059 WHO RELY ON EVIDENCE TO INFORM 9185 05:16:49,059 --> 05:16:51,361 BOTH GLOBAL AND NATIONAL HEALTH 9186 05:16:51,361 --> 05:16:52,996 DECISIONS, OUR FELLOW 9187 05:16:52,996 --> 05:16:55,065 SCIENTISTS, WHOSE WORK IS 9188 05:16:55,065 --> 05:16:55,932 ENRICHED THROUGH DELIBERATION 9189 05:16:55,932 --> 05:16:57,901 AND COLLABORATION, NOT 9190 05:16:57,901 --> 05:16:59,603 DISRUPTION, AND US CITIZENS 9191 05:16:59,603 --> 05:17:01,705 WHOSE HELP IS THE LINCHPIN OF A 9192 05:17:01,705 --> 05:17:03,140 VIBRANT NATION. 9193 05:17:03,140 --> 05:17:05,075 LIKEWISE, PROCESS MATTERS. 9194 05:17:05,075 --> 05:17:06,977 NEW INITIATIVES, NO MATTER HOW 9195 05:17:06,977 --> 05:17:08,645 PROMISING, REQUIRE THOUGHTFUL 9196 05:17:08,645 --> 05:17:11,148 IMPLEMENTATION STRATEGIES, 9197 05:17:11,148 --> 05:17:12,349 INCLUSIVE ENGAGEMENT AND 9198 05:17:12,349 --> 05:17:14,417 ITERATIVE FEEDBACK LOOPS. 9199 05:17:14,417 --> 05:17:15,952 IT'S EASY TO PILOT AS WE TALKED 9200 05:17:15,952 --> 05:17:17,687 ABOUT EARLIER, IT'S MUCH HARDER 9201 05:17:17,687 --> 05:17:18,755 TO SUSTAIN. 9202 05:17:18,755 --> 05:17:21,057 THE SUCCESS OF NIH PROGRAMS WILL 9203 05:17:21,057 --> 05:17:23,994 HINGE NOT JUST ON VISION, BUT ON 9204 05:17:23,994 --> 05:17:25,529 SCAFFOLDING THAT PRESERVES 9205 05:17:25,529 --> 05:17:26,696 INSTITUTIONAL MEMORY AND REWARDS 9206 05:17:26,696 --> 05:17:28,665 LEARNING ALONG THE WAY. 9207 05:17:28,665 --> 05:17:31,201 AND TECHNOLOGY, WHILE EXCITING 9208 05:17:31,201 --> 05:17:32,235 AND MY THING, MUST BE APPROACHED 9209 05:17:32,235 --> 05:17:34,538 WITH A COMMITMENT TO VALIDATION. 9210 05:17:34,538 --> 05:17:37,207 WHETHER WE'RE TALKING ABOUT AI, 9211 05:17:37,207 --> 05:17:39,176 MHEALTH, NOVEL DIAGNOSTICS, 9212 05:17:39,176 --> 05:17:40,710 THESE TOOLS ARE ONLY AS GOOD AS 9213 05:17:40,710 --> 05:17:42,846 THE DATA THAT SHAPED THEM AND 9214 05:17:42,846 --> 05:17:43,613 THE RIGOR WITH WHICH THEY ARE 9215 05:17:43,613 --> 05:17:45,182 TESTED. 9216 05:17:45,182 --> 05:17:48,518 INNOVATION WITHOUT VIR F VERIFIN 9217 05:17:48,518 --> 05:17:50,387 CAN UNINTENTIONALLY WIDEN 9218 05:17:50,387 --> 05:17:51,288 DISPARITIES OR ERODE PUBLIC 9219 05:17:51,288 --> 05:17:52,122 TRUST. 9220 05:17:52,122 --> 05:17:54,090 SO TO MY FELLOW COUNCILMEMBER, 9221 05:17:54,090 --> 05:17:54,391 THANK YOU. 9222 05:17:54,391 --> 05:17:57,227 YOU ARE NOT ONLY AMONG THE MOST 9223 05:17:57,227 --> 05:17:59,262 PRE-EMINENT SCHOLARS IN YOUR 9224 05:17:59,262 --> 05:18:01,798 RESPECTIVE FIELDS, YOU'RE 9225 05:18:01,798 --> 05:18:04,501 GENEROUS, THOUGHTFUL AND 9226 05:18:04,501 --> 05:18:06,336 COLLEGIAL, MAKING EVERY MEETING 9227 05:18:06,336 --> 05:18:07,671 FEEL LIKE A MASTER CLASS IN 9228 05:18:07,671 --> 05:18:08,438 SCIENCE AND LEADERSHIP, IT'S 9229 05:18:08,438 --> 05:18:10,006 BEEN AN HONOR TO WORK ALONGSIDE 9230 05:18:10,006 --> 05:18:10,774 YOU. 9231 05:18:10,774 --> 05:18:11,975 TO THE INCREDIBLE NIH STAFF WHO 9232 05:18:11,975 --> 05:18:12,943 SUPPORT OUR WORK BEHIND THE 9233 05:18:12,943 --> 05:18:15,078 SCENES, YOU ARE THE UNSUNG 9234 05:18:15,078 --> 05:18:16,613 BACKBONE OF THIS ENTERPRISE. 9235 05:18:16,613 --> 05:18:18,281 THANK YOU GROWR TIRELESS 9236 05:18:18,281 --> 05:18:19,482 COORDINATION, YOUR ATTENTION TO 9237 05:18:19,482 --> 05:18:20,884 DETAIL AND YOUR GRACE UNDER 9238 05:18:20,884 --> 05:18:21,151 PRESSURE. 9239 05:18:21,151 --> 05:18:23,086 YOU ARE THE CATALYST OF THE 9240 05:18:23,086 --> 05:18:24,721 NIH'S MISSION TO CREATE NEW 9241 05:18:24,721 --> 05:18:25,055 KNOWLEDGE. 9242 05:18:25,055 --> 05:18:27,257 YOU MAKE THE WORK POSSIBLE AND 9243 05:18:27,257 --> 05:18:28,658 FRANKLY BETTER. 9244 05:18:28,658 --> 05:18:30,493 SO I LEAVE THIS COMMITTEE WITH 9245 05:18:30,493 --> 05:18:31,595 GRATITUDE, CONVICTION AND HOPE, 9246 05:18:31,595 --> 05:18:35,465 AND WL THE COMMIT TOMENT KEEP 9247 05:18:35,465 --> 05:18:37,534 CHAMPIONING THE VALUES THAT HAVE 9248 05:18:37,534 --> 05:18:39,302 MOVED SCIENCE FORWARD. 9249 05:18:39,302 --> 05:18:42,839 PEOPLE, PROCESS, INNOVATION, 9250 05:18:42,839 --> 05:18:43,340 TECHNOLOGY AND HARMONY. 9251 05:18:43,340 --> 05:18:43,707 THANK YOU. 9252 05:18:43,707 --> 05:18:47,877 >> THANK YOU SO MUCH, KEVIN. 9253 05:18:47,877 --> 05:18:50,447 RHONDA, PLEASE GO AHEAD. 9254 05:18:50,447 --> 05:18:52,382 >> THANK YOU. 9255 05:18:52,382 --> 05:18:54,985 I WANT TO ITERATE OR REPEAT MANY 9256 05:18:54,985 --> 05:18:56,519 THINGS THAT KEVIN HAS ALREADY 9257 05:18:56,519 --> 05:18:58,255 SAID, PARTICULARLY IN TERMS OF 9258 05:18:58,255 --> 05:19:00,657 THE EXCELLENT SUPPORT THAT WE 9259 05:19:00,657 --> 05:19:03,026 RECEIVE FROM THE STAFF AT NIH, 9260 05:19:03,026 --> 05:19:06,396 BUT ALSO MORE IMPORTANTLY, THE 9261 05:19:06,396 --> 05:19:07,063 COLLEGIAL RELATIONSHIP WITH 9262 05:19:07,063 --> 05:19:10,433 THOSE WHO ARE ON THE COUNCIL OF 9263 05:19:10,433 --> 05:19:10,767 COUNCIL. 9264 05:19:10,767 --> 05:19:13,670 NOT BEING A RESEARCHER OR AN 9265 05:19:13,670 --> 05:19:14,571 ACADEMIC MEDICINE, BUT IN WHAT I 9266 05:19:14,571 --> 05:19:16,406 WOULD CALL MORE HEALTHCARE 9267 05:19:16,406 --> 05:19:18,508 DELIVERY, YOU HAVE GIVEN ME THE 9268 05:19:18,508 --> 05:19:20,343 OPPORTUNITY TO LEARN SO MUCH IN 9269 05:19:20,343 --> 05:19:23,313 TERMS OF NOT ONLY SCIENCE, 9270 05:19:23,313 --> 05:19:25,715 INNOVATION, AND NEW IDEAS, BUT 9271 05:19:25,715 --> 05:19:27,784 ALSO UNDERSTANDING THE 9272 05:19:27,784 --> 05:19:29,619 COMPLEXITY AND THE COMPLICATIONS 9273 05:19:29,619 --> 05:19:33,123 IN TERMS OF TRYING TO BRING 9274 05:19:33,123 --> 05:19:34,758 THOSE SCIENTIFIC IDEAS FORWARD. 9275 05:19:34,758 --> 05:19:37,460 SO I THANK YOU FOR THAT. 9276 05:19:37,460 --> 05:19:39,195 IT HAS ALLOWED ME TO BECOME 9277 05:19:39,195 --> 05:19:41,164 HUMBLE TO THE COMPLEXITY AND THE 9278 05:19:41,164 --> 05:19:43,033 DIFFICULTY IN BRINGING THINGS 9279 05:19:43,033 --> 05:19:43,266 FORWARD. 9280 05:19:43,266 --> 05:19:46,169 A LOT OF MY EARLY WORK IN THE 9281 05:19:46,169 --> 05:19:49,339 FIELD HAD TO DO WITH CROSSING 9282 05:19:49,339 --> 05:19:53,443 THE QUALLY CHASM, I WAS ON THAT 9283 05:19:53,443 --> 05:19:55,312 COMMITTEE SO I HOLD VERY DEAR 9284 05:19:55,312 --> 05:19:57,747 THE ISSUE OF A TAKING 17 YEARS 9285 05:19:57,747 --> 05:19:59,616 TO TAKE A SCIENTIFIC FACT AND 9286 05:19:59,616 --> 05:20:00,450 GET IT INTO DELIVERY INTO THE 9287 05:20:00,450 --> 05:20:00,884 SYSTEM. 9288 05:20:00,884 --> 05:20:02,652 AND SO THAT'S ONE OF THE THINGS 9289 05:20:02,652 --> 05:20:04,921 THAT'S HIGHLY MOTIVATED ME AND I 9290 05:20:04,921 --> 05:20:05,889 WILL SAY THAT MANY OF THE THINGS 9291 05:20:05,889 --> 05:20:08,191 THAT I'VE HEARD HERE OVER THE 9292 05:20:08,191 --> 05:20:09,592 YEARS, OVER THE 12 YEARS I'VE 9293 05:20:09,592 --> 05:20:11,661 BEEN INVOLVED NOT ONLY FROM THE 9294 05:20:11,661 --> 05:20:13,063 MENTAL HEALTH PERSPECTIVE BULL 9295 05:20:13,063 --> 05:20:14,397 FROM THE GENERAL MEDICAL 9296 05:20:14,397 --> 05:20:16,466 PERSPECTIVE, HAVE ENCOURAGED ME 9297 05:20:16,466 --> 05:20:18,301 THAT NIH IS TRYING TO CLOSE THAT 9298 05:20:18,301 --> 05:20:19,836 GAP AND TRYING TO CLOSE THE 9299 05:20:19,836 --> 05:20:21,137 NUMBER OF YEARS THAT IT TAKES TO 9300 05:20:21,137 --> 05:20:24,207 DO THIS. 9301 05:20:24,207 --> 05:20:25,709 WITH THAT BEING SAID, I WOULD 9302 05:20:25,709 --> 05:20:27,010 SAY THERE ARE SOME THINGS THAT I 9303 05:20:27,010 --> 05:20:28,011 THINK NIH BEING IN THE POSITION 9304 05:20:28,011 --> 05:20:31,381 THAT YOU HAVE, PARTICULARLY 9305 05:20:31,381 --> 05:20:34,551 BEING UNDER THE GUISE OF 9306 05:20:34,551 --> 05:20:36,820 CONGRESS AND OTHERS, THAT YOU 9307 05:20:36,820 --> 05:20:40,990 HAVE THE CONNECTION TO BE ABLE 9308 05:20:40,990 --> 05:20:43,626 TO NAVIGATE THE REGULATORY 9309 05:20:43,626 --> 05:20:46,496 WATERS AND I THINK IT WAS 9310 05:20:46,496 --> 05:20:49,899 MENTIONED BY ONE OF THE LAST 9311 05:20:49,899 --> 05:20:51,201 SPEAKERS, BE ABLE TO USE THAT IN 9312 05:20:51,201 --> 05:20:53,870 ORDER TO BRING THE FIELD TO MOVE 9313 05:20:53,870 --> 05:20:56,106 TOGETHER, AND TO BEGIN TO ENGAGE 9314 05:20:56,106 --> 05:20:57,640 IN TERMS OF COMMITMENT. 9315 05:20:57,640 --> 05:20:59,476 I THINK THE ONE THING THAT WE 9316 05:20:59,476 --> 05:21:01,878 REALLY DON'T WANT IS TO CREATE, 9317 05:21:01,878 --> 05:21:03,179 PARTICULARLY IN THIS WORLD OF 9318 05:21:03,179 --> 05:21:07,450 NEW INNOVATIONS, IS 9319 05:21:07,450 --> 05:21:09,285 FRAGMENTATION THAT CAUSE MORE 9320 05:21:09,285 --> 05:21:10,253 PROBLEMS IN THE LONG RUN, AND 9321 05:21:10,253 --> 05:21:11,588 I'LL JUST CITE ELECTRONIC 9322 05:21:11,588 --> 05:21:12,756 MEDICAL RECORDS AS ONE OF THE 9323 05:21:12,756 --> 05:21:13,990 MAJOR ONES AS AN EXAMPLE FROM 9324 05:21:13,990 --> 05:21:16,359 THE VERY BEGINNING THAT BECAME 9325 05:21:16,359 --> 05:21:17,594 PRIVATIZED BUT CERTAINLY CREATED 9326 05:21:17,594 --> 05:21:23,566 A BUNCH OF FRAGMENTATION AND 9327 05:21:23,566 --> 05:21:24,200 COSTS ON THE PARTS OF HEALTH 9328 05:21:24,200 --> 05:21:24,534 SYSTEM. 9329 05:21:24,534 --> 05:21:26,836 SO THE MAJOR THINGS I WANT TO 9330 05:21:26,836 --> 05:21:29,873 SAY IS THAT SCIENCE IS AB 9331 05:21:29,873 --> 05:21:30,740 ABSOLUTELY SIGNIFICANT AND 9332 05:21:30,740 --> 05:21:32,375 ESSENTIAL, BUT IT HAS TO BE 9333 05:21:32,375 --> 05:21:32,942 TRUSTED SCIENCE. 9334 05:21:32,942 --> 05:21:34,811 AS I'VE MENTIONED EARLIER TODAY, 9335 05:21:34,811 --> 05:21:36,746 BEING ABLE TO COMMUNICATE THE 9336 05:21:36,746 --> 05:21:40,016 SCIENCE NOT ONLY TO THOSE WHO 9337 05:21:40,016 --> 05:21:43,119 CAN DIRECTLY USE IT, RPG BEYOND 9338 05:21:43,119 --> 05:21:44,788 THE WAYS THAT ARE BEING DONE 9339 05:21:44,788 --> 05:21:46,456 RIGHT NOW SO A WIDE 9340 05:21:46,456 --> 05:21:47,457 DISSEMINATION AND ACKNOWLEDGMENT 9341 05:21:47,457 --> 05:21:48,825 BUT ALSO TO THE PUBLIC, AND 9342 05:21:48,825 --> 05:21:50,560 BEING ABLE TO EXPLAIN TO THE 9343 05:21:50,560 --> 05:21:52,529 PUBLIC IN A WAY THAT WILL IT CAN 9344 05:21:52,529 --> 05:21:53,430 BE DIGESTED. 9345 05:21:53,430 --> 05:21:56,199 I WOULD ALSO SUGGEST THAT 9346 05:21:56,199 --> 05:21:58,535 PRIVATE SECTOR BE INVOLVED IN 9347 05:21:58,535 --> 05:22:00,703 TERMS OF HELPING YOU TO SHAPE 9348 05:22:00,703 --> 05:22:06,242 WHAT ARE THE AREAS THAT ARE MOST 9349 05:22:06,242 --> 05:22:07,143 IMPORTANT FROM THE PRIVATE 9350 05:22:07,143 --> 05:22:08,344 SECTOR PERSPECTIVE, THERE ARE 9351 05:22:08,344 --> 05:22:09,212 MANY PAIN POINTS THAT ARE OUT 9352 05:22:09,212 --> 05:22:14,150 THERE THAT CAN BE HELPED BY 9353 05:22:14,150 --> 05:22:14,984 ATTENTION BY NIH, PARTICULARLY 9354 05:22:14,984 --> 05:22:16,286 IN TERMS OF FURTHERING RESEARCH, 9355 05:22:16,286 --> 05:22:17,821 BUT MORE IMPORTANTLY, BRINGING 9356 05:22:17,821 --> 05:22:19,155 THAT RESEARCH IN TO THE REAL 9357 05:22:19,155 --> 05:22:20,957 WORLD SO THAT THERE IS IMMEDIATE 9358 05:22:20,957 --> 05:22:25,895 LEARNINGS THAT CAN OCCUR NOT 9359 05:22:25,895 --> 05:22:27,797 ONLY IN TERMS OF THE DATA THAT'S 9360 05:22:27,797 --> 05:22:28,598 COLLECT AND ANALYSIS BUT ALSO IN 9361 05:22:28,598 --> 05:22:29,766 TERMS OF DIRECTLY TO PROVIDERS 9362 05:22:29,766 --> 05:22:31,134 WHO ARE ENGAGED IN THIS AS WELL 9363 05:22:31,134 --> 05:22:32,602 AS THE PATIENTS. 9364 05:22:32,602 --> 05:22:34,571 I WOULD ALSO SAY THE AREA THAT I 9365 05:22:34,571 --> 05:22:37,273 THINK IS REAL IMPORTANT IS THE 9366 05:22:37,273 --> 05:22:37,574 GOVERNANCE. 9367 05:22:37,574 --> 05:22:39,409 AND THAT, I WOULD SAY YOU'RE 9368 05:22:39,409 --> 05:22:43,079 VERY GOOD AT PULLING TOGETHER 9369 05:22:43,079 --> 05:22:44,614 ALL YOUR DIVISIONS AND ALSO 9370 05:22:44,614 --> 05:22:46,349 PULLING IN MANY GOVERNMENTAL 9371 05:22:46,349 --> 05:22:48,751 ENTITIES, BUT I THINK IN ORDER 9372 05:22:48,751 --> 05:22:50,186 TO REALLY FURTHER WHAT YOU'RE 9373 05:22:50,186 --> 05:22:53,223 DOING IN BRINGING TO THE REAL 9374 05:22:53,223 --> 05:22:55,625 WORLD WITH ADOPTION AND 9375 05:22:55,625 --> 05:22:56,493 IMPLEMENTATION NEED TO AGAIN 9376 05:22:56,493 --> 05:22:59,095 BRING IN OTHER STAKEHOLDERS, I 9377 05:22:59,095 --> 05:23:00,430 WOULD CITE ONE OF THE AREAS THAT 9378 05:23:00,430 --> 05:23:03,833 IS REAL IMPORTANT IN TERMS OF 9379 05:23:03,833 --> 05:23:04,868 INNOVATION AND MOVING THINGS 9380 05:23:04,868 --> 05:23:06,469 FORWARD BESIDES THE RESEARCH AND 9381 05:23:06,469 --> 05:23:08,605 THE FUNDING THAT YOU BRING 9382 05:23:08,605 --> 05:23:10,240 FORWARD WOULD BE FUNDING THAT 9383 05:23:10,240 --> 05:23:12,876 COME FROM OTHER ORGANIZATIONS. 9384 05:23:12,876 --> 05:23:16,346 ALIGNMENT AROUND THOSE 9385 05:23:16,346 --> 05:23:17,447 ORGANIZATIONS, CONSOLIDATING OR 9386 05:23:17,447 --> 05:23:20,183 FOCUSING THEIR FUNDING, THEIR 9387 05:23:20,183 --> 05:23:21,951 PHILANTHROPIC FUNDING WILL BRING 9388 05:23:21,951 --> 05:23:23,486 MORE POWER TO THE SYSTEM TO BE 9389 05:23:23,486 --> 05:23:27,290 ABLE TO MAKE CHANGES IN ORDER TO 9390 05:23:27,290 --> 05:23:28,157 ACCOMMODATE THE RESEARCH THAT 9391 05:23:28,157 --> 05:23:29,025 YOU'VE GIVEN. 9392 05:23:29,025 --> 05:23:31,861 SO WITH THAT, WITH MY 12 YEARS 9393 05:23:31,861 --> 05:23:33,496 BEING HERE, AGAIN, I'M VERY 9394 05:23:33,496 --> 05:23:35,899 GRATEFUL FOR THE OPPORTUNITY. 9395 05:23:35,899 --> 05:23:37,967 I'VE LEARNED A LOT. 9396 05:23:37,967 --> 05:23:39,402 I'M SURE THERE'S MORE TO BE 9397 05:23:39,402 --> 05:23:40,770 LEARNED, AND I WILL CONTINUE TO 9398 05:23:40,770 --> 05:23:42,805 FOLLOW YOU ON THE WEB, BUT I 9399 05:23:42,805 --> 05:23:44,307 REALLY WANT TO SAY THAT IT'S 9400 05:23:44,307 --> 05:23:46,442 BEEN A FABULOUS OPPORTUNITY, AND 9401 05:23:46,442 --> 05:23:48,745 THANK YOU SO MUCH. 9402 05:23:48,745 --> 05:23:52,081 >> THANK YOU SO MUCH, RHONDA. 9403 05:23:52,081 --> 05:23:52,982 LINDA, PLEASE GO AHEAD. 9404 05:23:52,982 --> 05:23:54,050 >> HI. 9405 05:23:54,050 --> 05:23:57,654 I JUST ALSO WANT TO THANK -- 9406 05:23:57,654 --> 05:24:00,823 EXPRESS MY GRATITUDE FOR -- AND 9407 05:24:00,823 --> 05:24:03,192 HONOR, I FELT VERY HONORED TO 9408 05:24:03,192 --> 05:24:05,128 HAVE BEEN PART OF THIS 9409 05:24:05,128 --> 05:24:07,664 COMMITTEE, AND TO BE ON THE 9410 05:24:07,664 --> 05:24:08,197 COUNCIL. 9411 05:24:08,197 --> 05:24:10,466 ALTHOUGH I SERVED ON THE NIDA 9412 05:24:10,466 --> 05:24:13,202 COUNCIL AND THE BSC, NIDA IN THE 9413 05:24:13,202 --> 05:24:14,637 PAST, I THINK BEING ON THIS 9414 05:24:14,637 --> 05:24:15,505 COMMITTEE, THIS COUNCIL REALLY 9415 05:24:15,505 --> 05:24:17,340 GAVE ME A MUCH BROADER 9416 05:24:17,340 --> 05:24:19,509 PERSPECTIVE OF HOW NIH 9417 05:24:19,509 --> 05:24:21,177 FUNCTIONED AND SO IT'S REALLY 9418 05:24:21,177 --> 05:24:23,446 BEEN A TREMENDOUS LEARNING 9419 05:24:23,446 --> 05:24:24,647 EXPERIENCE FOR ME, SO I'M VERY 9420 05:24:24,647 --> 05:24:30,687 GRATEFUL FOR THAT, AND THESE SIX 9421 05:24:30,687 --> 05:24:31,788 YEARS SEEM TO HAVE PASSED LIKE 9422 05:24:31,788 --> 05:24:33,189 THE BLINK OF AN EYE AND IT SEEMS 9423 05:24:33,189 --> 05:24:35,592 LIKE I THINK WE KIND OF MISSED 9424 05:24:35,592 --> 05:24:36,793 OUT A LITTLE BIT BECAUSE OF 9425 05:24:36,793 --> 05:24:39,062 COVID THAT WE DIDN'T HAVE AS 9426 05:24:39,062 --> 05:24:42,231 MANY IN-PERSON, WE HAD VERY FEW 9427 05:24:42,231 --> 05:24:44,434 IN-PERSON MEETINGS AS A RESULT 9428 05:24:44,434 --> 05:24:48,905 OF THAT, AND I THINK HAVING THE 9429 05:24:48,905 --> 05:24:50,340 IN-PERSON MEETING REALLY DOES 9430 05:24:50,340 --> 05:24:53,943 ADD VALUE TO THE COMMUNICATION 9431 05:24:53,943 --> 05:24:57,013 BETWEEN THE MEMBERS AND THE 9432 05:24:57,013 --> 05:24:58,514 DISCUSSION. 9433 05:24:58,514 --> 05:24:59,616 I DEFINITELY FELT THAT 9434 05:24:59,616 --> 05:25:03,119 ESPECIALLY EARLY ON DURING THE 9435 05:25:03,119 --> 05:25:04,320 PANDEMIC WHEN WE STARTED DOING 9436 05:25:04,320 --> 05:25:05,888 ALL THIS VIRTUAL MEETING, 9437 05:25:05,888 --> 05:25:07,924 EVERYTHING IS JUST, YOU KNOW, IT 9438 05:25:07,924 --> 05:25:10,426 WAS VERY MATTER OF FACT, 9439 05:25:10,426 --> 05:25:12,729 EVERYONE JUST REPORTS AND THE 9440 05:25:12,729 --> 05:25:15,698 DISCUSSION JUST WASN'T AS 9441 05:25:15,698 --> 05:25:18,434 ENGAGING AS THEY WERE, HAD WE 9442 05:25:18,434 --> 05:25:20,403 BEEN IN A IN-PERSON SETTING. 9443 05:25:20,403 --> 05:25:22,472 SO THAT'S MY ONLY FEEDBACK ABOUT 9444 05:25:22,472 --> 05:25:29,245 THAT, AND OTHERWISE I WANTED TO 9445 05:25:29,245 --> 05:25:31,748 THANK THE DPCPSI PROGRAM, THE 9446 05:25:31,748 --> 05:25:33,449 STAFF, EVERY, I'VE HAD A 9447 05:25:33,449 --> 05:25:33,916 WONDERFUL EXPERIENCE. 9448 05:25:33,916 --> 05:25:39,122 THANK YOU. 9449 05:25:39,122 --> 05:25:44,093 >> TH THANK YOU SO MUCH, LINDA. 9450 05:25:44,093 --> 05:25:44,327 OKAY. 9451 05:25:44,327 --> 05:25:46,162 I'M NOT SEEING ANY OTHER HANDS 9452 05:25:46,162 --> 05:25:49,232 RAISED. 9453 05:25:49,232 --> 05:25:51,734 I WILL NOTE THAT SUSAN PUT HER 9454 05:25:51,734 --> 05:25:55,338 COMMENTS IN THE CHAT. 9455 05:25:55,338 --> 05:25:58,508 SO I WILL JUST CLOSE BY SAYING, 9456 05:25:58,508 --> 05:26:02,311 YOU KNOW, I AM INCREDIBLY 9457 05:26:02,311 --> 05:26:05,448 GRATEFUL, BOTH ON BEHALF OF 9458 05:26:05,448 --> 05:26:07,483 DPCPSI AND NIH, BUT FOR MYSELF 9459 05:26:07,483 --> 05:26:10,453 PERSONALLY, BECAUSE THIS HAS 9460 05:26:10,453 --> 05:26:12,088 BEEN AN EXTRAORDINARILY HELPFUL 9461 05:26:12,088 --> 05:26:13,923 EXPERIENCE AS I LEARN MORE ABOUT 9462 05:26:13,923 --> 05:26:14,957 DPCPSI AND I JUST REALLY 9463 05:26:14,957 --> 05:26:18,327 APPRECIATE ALL OF THE THOUGHTFUL 9464 05:26:18,327 --> 05:26:19,228 INPUT AND CRITICAL DISCUSSION 9465 05:26:19,228 --> 05:26:21,831 AND CONSTRUCTIVE FEEDBACK THAT 9466 05:26:21,831 --> 05:26:22,865 WAS PROVIDED TODAY, AND I'M 9467 05:26:22,865 --> 05:26:25,468 REALLY LOOKING FORWARD TO GET 9468 05:26:25,468 --> 05:26:28,337 GETTING TO KNOW ALL OF YOU 9469 05:26:28,337 --> 05:26:29,972 BETTER, AND I HOPE THAT MANY OF 9470 05:26:29,972 --> 05:26:31,174 THE COUNCILMEMBERS WHO ARE 9471 05:26:31,174 --> 05:26:33,376 ROTATING OFF WILL STILL CONTINUE 9472 05:26:33,376 --> 05:26:34,577 TO REMAIN ENGAGED THROUGH OUR 9473 05:26:34,577 --> 05:26:34,944 WORKING GROUPS. 9474 05:26:34,944 --> 05:26:37,513 I THINK WE ALREADY HAD SOME 9475 05:26:37,513 --> 05:26:39,015 EXPRESSIONS OF COMMITMENT 9476 05:26:39,015 --> 05:26:39,849 EARLIER IN THE DAY FROM SOME OF 9477 05:26:39,849 --> 05:26:41,350 THOSE FOLKS, SO THAT'S 9478 05:26:41,350 --> 05:26:42,118 FANTASTIC. 9479 05:26:42,118 --> 05:26:45,655 I AM DELIGHTED TO INFORM YOU ALL 9480 05:26:45,655 --> 05:26:46,155 THAT THE NEXT COUNCIL OF 9481 05:26:46,155 --> 05:26:48,858 COUNCILS MEETING WILL BE IN 9482 05:26:48,858 --> 05:26:50,493 PERSON, AND IT IS SCHEDULED FOR 9483 05:26:50,493 --> 05:26:53,496 MAY 29TH AND 30TH, SO WE REALLY 9484 05:26:53,496 --> 05:26:56,199 LOOK FORWARD TO SEEING YOU NEXT 9485 05:26:56,199 --> 05:26:56,766 MONTH. 9486 05:26:56,766 --> 05:26:57,834 SO FRANZISKA, ANYTHING ELSE? 9487 05:26:57,834 --> 05:26:59,302 NO? 9488 05:26:59,302 --> 05:26:59,502 OKAY. 9489 05:26:59,502 --> 05:27:00,770 WHERE DID MY GAVEL GO? 9490 05:27:00,770 --> 05:27:01,204 OKAY. 9491 05:27:01,204 --> 05:27:01,871 THERE. 9492 05:27:01,871 --> 05:27:02,839 THE COUNCIL MEETING IS 9493 05:27:02,839 --> 05:27:04,107 ADJOURNED. 9494 05:27:04,107 --> 05:27:14,417 >> THANK YOU ALL.