1 00:00:05,560 --> 00:03:03,160 >>WELCOME TO DATAWORKS 2 00:03:03,160 --> 00:03:07,040 YOU'LL HEAR FROM THE LAB 3 00:03:07,040 --> 00:03:13,480 REMOVING METADATA BARRIERS AND 4 00:03:13,480 --> 00:03:31,880 TEAM CAPTAIN. 5 00:03:31,880 --> 00:03:33,680 AND I WANT TO CONGRATULATE ALL 6 00:03:33,680 --> 00:03:34,560 OF OUR WINNERS. 7 00:03:34,560 --> 00:03:36,040 THIS IS A PERFECT TIME TO 8 00:03:36,040 --> 00:03:38,040 HIGHLIGHT THE IMPACT OF 9 00:03:38,040 --> 00:03:39,720 INNOVATIVE DATA SHARING AND 10 00:03:39,720 --> 00:03:40,520 PRACTICES. 11 00:03:40,520 --> 00:03:43,440 I'M SURE MOST OF YOU KNOW THAT 12 00:03:43,440 --> 00:03:46,440 THE 2023 POLICY JUST WENT INTO 13 00:03:46,440 --> 00:03:49,000 EFFECT OVER THREE MONTHS AGO 14 00:03:49,000 --> 00:03:51,000 TODAY SO WE'RE CELEBRATING THAT 15 00:03:51,000 --> 00:03:52,600 AND ALSO RECOGNIZING AND 16 00:03:52,600 --> 00:03:54,520 REQUIRING THAT NIH RESEARCHERS 17 00:03:54,520 --> 00:03:56,840 CREATE AND PLAN FOR DATA STORAGE 18 00:03:56,840 --> 00:03:58,040 AND DATA SHARING. 19 00:03:58,040 --> 00:04:00,840 I HOPE THESE STORIES INSPIRE YOU 20 00:04:00,840 --> 00:04:02,600 WHEN YOU'RE THINKING ABOUT YOUR 21 00:04:02,600 --> 00:04:05,680 DATA MANAGEMENT AND SHARING 22 00:04:05,680 --> 00:04:06,480 CAPABILITIES. 23 00:04:06,480 --> 00:04:08,080 THROUGH THIS AND OTHER POLICIES 24 00:04:08,080 --> 00:04:10,200 NIH IS SUPPORTING A CULTURE OF 25 00:04:10,200 --> 00:04:14,480 DATA SHARING AND DATA REUSE. 26 00:04:14,480 --> 00:04:16,680 YOU'LL ALSO OVER HEAR DATA 27 00:04:16,680 --> 00:04:20,560 SHARING AND REUSE THAT IS 28 00:04:20,560 --> 00:04:24,520 SUPPORTING IN ADVANCEMENTS IN 29 00:04:24,520 --> 00:04:25,400 HUMAN HEALTH. 30 00:04:25,400 --> 00:04:28,000 I ENCOURAGE YOU TO JOIN ME IN 31 00:04:28,000 --> 00:04:30,920 CELEBRATING OUR 2022 WINNERS AND 32 00:04:30,920 --> 00:04:33,800 EXAMINE HOW YOU AND YOUR 33 00:04:33,800 --> 00:04:35,880 COLLEAGUES CAN USE SOME OF THESE 34 00:04:35,880 --> 00:04:38,720 APPROACHES IN YOUR OWN RESEARCH. 35 00:04:38,720 --> 00:04:46,920 WE'LL USE sli.do FOR Q&A. 36 00:04:46,920 --> 00:04:48,760 IT'S NUMBER 1379. 37 00:04:48,760 --> 00:04:51,200 I'M EXCITED AND HOPEFUL THAT WE 38 00:04:51,200 --> 00:04:52,960 CAN CONTINUE THIS EXCELLENT 39 00:04:52,960 --> 00:04:55,840 PARTICIPATION AND COLLABORATION 40 00:04:55,840 --> 00:04:59,680 WITH FASEB IN 2023 AND BEYOND. 41 00:04:59,680 --> 00:05:01,080 SO LET'S GET STARTED. 42 00:05:01,080 --> 00:05:05,600 JOIN ME IN WELCOMING DR. JAKOB 43 00:05:05,600 --> 00:05:08,840 SEIDLITZ AND ANDREIA VACONCELLOS 44 00:05:08,840 --> 00:05:14,760 FARIA TO TELL US ABOUT THEIR 45 00:05:14,760 --> 00:05:17,120 WORK AND THE BRAIN CHART FOR 46 00:05:17,120 --> 00:05:18,800 HUMAN LIFE-SPAN AND THANKS AGAIN 47 00:05:18,800 --> 00:05:20,160 AND WELCOME. 48 00:05:20,160 --> 00:05:22,320 OVER TO YOU JAKOB. 49 00:05:22,320 --> 00:05:22,800 >>AWESOME. 50 00:05:22,800 --> 00:05:28,720 THANK YOU SO MUCH SUSAN FOR THE 51 00:05:28,720 --> 00:05:30,760 INTRO AND FOR THE OPPORTUNITY TO 52 00:05:30,760 --> 00:05:32,680 SPEAK WITH YOU ALL ABOUT OUR 53 00:05:32,680 --> 00:05:33,080 WORK. 54 00:05:33,080 --> 00:05:35,400 I'M JUST GOING TO SHARE MY 55 00:05:35,400 --> 00:05:35,880 SCREEN. 56 00:05:35,880 --> 00:05:41,080 HERE WE GO. 57 00:05:41,080 --> 00:05:44,840 AND I'LL TALK BRIEFLY ABOUT OUR 58 00:05:44,840 --> 00:05:46,600 PROJECT CALLED BRAIN CHARTS FOR 59 00:05:46,600 --> 00:05:48,400 THE HUMAN LIFE-SPAN. 60 00:05:48,400 --> 00:05:51,200 GENERALLY THIS IS A GRASSROOTS 61 00:05:51,200 --> 00:05:51,720 EFFORTS. 62 00:05:51,720 --> 00:05:54,720 ME AND A FEW OTHERS STARTED THIS 63 00:05:54,720 --> 00:05:59,200 AT THE BEGINNING OF THE PANDEMIC 64 00:05:59,200 --> 00:06:01,680 AND OUR RESPECTIVE HOME OFFICES 65 00:06:01,680 --> 00:06:08,120 AND IT QUICKLY GREW TO OVER 200 66 00:06:08,120 --> 00:06:09,720 CO-AUTHORS AND THE RESULTING 67 00:06:09,720 --> 00:06:10,360 PUBLICATION. 68 00:06:10,360 --> 00:06:12,240 I WANT TO CENTER THE DISCUSSION 69 00:06:12,240 --> 00:06:13,960 TODAY IN TERMS OF OUR WORK AND 70 00:06:13,960 --> 00:06:15,960 THE WORK IN GENERAL AROUND THIS 71 00:06:15,960 --> 00:06:18,040 IDEA OF DATA REPURPOSING. 72 00:06:18,040 --> 00:06:21,000 WHICH I THINK HIGHLIGHTS THE 73 00:06:21,000 --> 00:06:22,960 LINK BETWEEN DATA SHARING 74 00:06:22,960 --> 00:06:25,200 PRACTICES AND DATA REUSE 75 00:06:25,200 --> 00:06:28,160 PRACTICES TOGETHER ALONGSIDE OF 76 00:06:28,160 --> 00:06:29,840 EXPERTISE SCIENTIFIC QUESTIONS 77 00:06:29,840 --> 00:06:33,080 AND INNOVATION FACILITATE 78 00:06:33,080 --> 00:06:34,400 SCIENTIFIC DISCOVERY. 79 00:06:34,400 --> 00:06:36,960 I THINK ULTIMATELY OUR EFFORTS 80 00:06:36,960 --> 00:06:40,560 CENTERED AROUND TWO VERY 81 00:06:40,560 --> 00:06:42,560 FUNDAMENTAL QUESTIONS THAT HAVE 82 00:06:42,560 --> 00:06:46,560 ELUDED US FOR DECADES IN HUMAN 83 00:06:46,560 --> 00:06:47,960 NEUROSCIENCE. 84 00:06:47,960 --> 00:06:50,840 THE FIRST OF WHICH IS THIS VERY 85 00:06:50,840 --> 00:06:53,360 BASIC QUESTION OF BRAIN SIZE. 86 00:06:53,360 --> 00:07:00,400 IF YOU ASK GOOGLE OR CHAT VPT 87 00:07:00,400 --> 00:07:06,680 HOW BIG THE BRAIN IS IT GIVES 88 00:07:06,680 --> 00:07:10,080 YOU REASONABLE AVERAGES. 89 00:07:10,080 --> 00:07:12,560 THEY WILL ASK ABOUT WHEN. 90 00:07:12,560 --> 00:07:13,680 ABOUT WHO. 91 00:07:13,680 --> 00:07:15,320 ABOUT DIFFERENT CLINICAL 92 00:07:15,320 --> 00:07:16,360 CONDITIONS ETC. 93 00:07:16,360 --> 00:07:18,280 THE POINT BEING IS THAT WE HAVE 94 00:07:18,280 --> 00:07:22,160 YET TO REALLY MAP THIS SIMPLE 95 00:07:22,160 --> 00:07:25,200 PARAMETER ABOUT BRAIN STRUCTURE 96 00:07:25,200 --> 00:07:27,040 ACROSS THE LIFE SCORES AND I'LL 97 00:07:27,040 --> 00:07:37,360 GIVE SOME INSIGHT. 98 00:07:39,080 --> 00:07:41,880 THE OTHER REALLY FUNDAMENTAL 99 00:07:41,880 --> 00:07:44,480 ASPECT OF CLINICAL BRAIN SCIENCE 100 00:07:44,480 --> 00:07:47,320 IS THAT WE DON'T REALLY MEASURE 101 00:07:47,320 --> 00:07:48,440 BRAIN HEALTH. 102 00:07:48,440 --> 00:07:51,320 AND THIS PUTS FORTH THE NATURAL 103 00:07:51,320 --> 00:07:53,680 QUESTION IS HOW ARE WE SUPPOSED 104 00:07:53,680 --> 00:07:55,960 TO MEASURE BRAIN DISEASE. 105 00:07:55,960 --> 00:08:01,560 WE MEASURE IN UTERO WITH SIMPLE 106 00:08:01,560 --> 00:08:04,840 MEASUREMENTS AND POSTNATALLY WE 107 00:08:04,840 --> 00:08:06,400 USE GROWTH CHARTS. 108 00:08:06,400 --> 00:08:08,920 WHICH HAVE BEEN AROUND FOR OVER 109 00:08:08,920 --> 00:08:10,600 A COUPLE OF HUNDRED YEARS. 110 00:08:10,600 --> 00:08:14,000 THIS IS ONE OF THE FIRST PLOTS. 111 00:08:14,000 --> 00:08:19,840 OF HEIGHT. 112 00:08:19,840 --> 00:08:23,120 AND YOU FAST-FORWARD TODAY AND 113 00:08:23,120 --> 00:08:27,640 THE PEDIATRICIAN'S OFFICE -- THE 114 00:08:27,640 --> 00:08:31,800 ONLY WAY IS WITH A TAPE 115 00:08:31,800 --> 00:08:32,480 MEASURERRER. 116 00:08:32,480 --> 00:08:38,440 SO MRI IS A POPULAR SENSE. 117 00:08:38,440 --> 00:08:40,480 SO EVEN IF YOU WERE TO STUDY 118 00:08:40,480 --> 00:08:45,200 SOMEONE YOU WOULD STILL ONLY GET 119 00:08:45,200 --> 00:08:47,680 ABOUT 30 YEARS. 120 00:08:47,680 --> 00:08:51,320 YET WE CAN USE MRI TO MAP PEOPLE 121 00:08:51,320 --> 00:08:53,960 ACROSS ANY AGE FROM PREGNANCY 122 00:08:53,960 --> 00:08:55,640 ALL THE WAY UNTIL LATE 123 00:08:55,640 --> 00:08:56,960 ADULTHOOD. 124 00:08:56,960 --> 00:08:59,520 AND THIS PLOT IS REALLY 125 00:08:59,520 --> 00:09:01,200 STAGGERING IN TERMS OF THE SCOPE 126 00:09:01,200 --> 00:09:03,280 OF MRI TECHNOLOGY RELATIVE TO 127 00:09:03,280 --> 00:09:07,320 THE CLINICAL INFRASTRUCTURE AND 128 00:09:07,320 --> 00:09:11,720 THE ULTRASOUND ASPECT IN UTERO. 129 00:09:11,720 --> 00:09:14,400 AND ONE OF THE THINGS FOR THE 130 00:09:14,400 --> 00:09:16,240 TRAINEES IS WHEN YOU LOOK AT THE 131 00:09:16,240 --> 00:09:17,760 LITERATURE SOMETIMES YOU SEE 132 00:09:17,760 --> 00:09:20,760 PLOTS LIKE THIS FROM THE 133 00:09:20,760 --> 00:09:26,080 WONDERFUL REVIEW PAPER FROM JOHN 134 00:09:26,080 --> 00:09:27,600 GILMORE YOU HAVE THE ESTIMATES 135 00:09:27,600 --> 00:09:30,800 OF HOW THE BRAIN CHANGES OR 136 00:09:30,800 --> 00:09:32,520 PROPERTY CHANGES ACROSS TIME AND 137 00:09:32,520 --> 00:09:33,920 PEOPLE. 138 00:09:33,920 --> 00:09:37,240 BUT THIS IS QUALITATIVELY 139 00:09:37,240 --> 00:09:38,160 STITCHING TOGETHER PREVIOUS 140 00:09:38,160 --> 00:09:39,720 LITERATURE AND WE LACK STANDARDS 141 00:09:39,720 --> 00:09:42,600 FOR MEASURING BRAIN SIZE OR 142 00:09:42,600 --> 00:09:45,760 BRAIN GROWTH ACROSS THE 143 00:09:45,760 --> 00:09:47,840 PARI-NATAL PERIOD AND THIS 144 00:09:47,840 --> 00:09:50,440 NOTION OF THIS STUDY IN OUR 145 00:09:50,440 --> 00:09:53,400 FIELD ENCOMPASSES 90% OF 146 00:09:53,400 --> 00:09:58,000 LIFE-SPAN STUDIES START ABOUT 147 00:09:58,000 --> 00:09:59,600 2-5 YEARS OF AGE AND THIS 148 00:09:59,600 --> 00:10:01,520 PROBLEM OF BIRTH WHERE WE CAN 149 00:10:01,520 --> 00:10:05,280 MEASURE MRI IN UTERO BUT 150 00:10:05,280 --> 00:10:09,200 TYPICALLY THOSE STUDIES ARE NOT 151 00:10:09,200 --> 00:10:11,000 TRAVERSING THAT BIRTH WITHIN AN 152 00:10:11,000 --> 00:10:13,440 INDIVIDUAL PERSON SO WE'RE NOT 153 00:10:13,440 --> 00:10:15,560 LEARNING ABOUT AN INDIVIDUAL'S 154 00:10:15,560 --> 00:10:16,800 TRAJECTORY. 155 00:10:16,800 --> 00:10:20,200 SO I JUST WANT TO HIGHLIGHT THAT 156 00:10:20,200 --> 00:10:23,520 THERE ARE MORE THAN A FEW 157 00:10:23,520 --> 00:10:25,080 PORTABLE MRI TECHNOLOGIES THAT 158 00:10:25,080 --> 00:10:26,440 HAVE COME ON-LINE. 159 00:10:26,440 --> 00:10:31,240 SO THE SCALE OF MRI AND THE 160 00:10:31,240 --> 00:10:34,400 SCOPE IS DRASTICALLY CHANGING. 161 00:10:34,400 --> 00:10:35,600 AND THE OTHER OPPORTUNITY IN 162 00:10:35,600 --> 00:10:37,760 THIS SPACE IS THAT WE CAN 163 00:10:37,760 --> 00:10:40,040 QUANTIFY BRAIN DEVELOPMENT OR 164 00:10:40,040 --> 00:10:42,280 BRAIN GROWTH REALLY ROBUSTLY 165 00:10:42,280 --> 00:10:44,840 WITH AMAZING OPEN SCIENCE TOOLS 166 00:10:44,840 --> 00:10:47,400 AND RESEARCH GRADE TOOLS AND 167 00:10:47,400 --> 00:10:49,920 PREVIOUS SCIENTIFIC DISCOVERIES 168 00:10:49,920 --> 00:10:51,920 BEFORE AND THIS IS A VIDEO FROM 169 00:10:51,920 --> 00:10:58,640 A COUPLE OF OUR CO-AUTHORS AND 170 00:10:58,640 --> 00:11:01,080 YOU CAN SEE THE EXPANSION AND 171 00:11:01,080 --> 00:11:02,960 THE FOLDING THAT OCCURS 172 00:11:02,960 --> 00:11:05,480 ESPECIALLY LATER DURING 173 00:11:05,480 --> 00:11:06,640 PREGNANCY. 174 00:11:06,640 --> 00:11:10,880 AND PRIOR TO A FEW YEARS AGO -- 175 00:11:10,880 --> 00:11:13,520 USED SOME OF THESE BRAIN CHARTS 176 00:11:13,520 --> 00:11:16,600 NOT OURS BUT SOME BRAIN CHARTS 177 00:11:16,600 --> 00:11:20,000 FROM A SMALL DATASET BETWEEN 0-5 178 00:11:20,000 --> 00:11:24,440 TO MAP THE RESPONSE FOR A SHUNT 179 00:11:24,440 --> 00:11:32,680 FOR HIDE THROW AT THE PLUS * 180 00:11:32,680 --> 00:11:33,080 PATIENTS. 181 00:11:33,080 --> 00:11:34,880 YOU CAN SEE THAT USING THESE 182 00:11:34,880 --> 00:11:36,560 CHARTS THE SUBJECT CAN BE 183 00:11:36,560 --> 00:11:40,240 MATCHED FROM HAVING A LOW BRAIN 184 00:11:40,240 --> 00:11:43,760 SIZE TO BEING KIND OF BACK ON 185 00:11:43,760 --> 00:11:46,280 TRACK AFTER INTERVENTION. 186 00:11:46,280 --> 00:11:51,120 SO THERE IS A CLEAR CLINICAL 187 00:11:51,120 --> 00:11:53,800 NEED FOR THIS AND MANY PEOPLE 188 00:11:53,800 --> 00:11:55,760 HAVE MAPPED VARIOUS CASE VERSUS 189 00:11:55,760 --> 00:11:57,760 CONTROL EFFECTS. 190 00:11:57,760 --> 00:12:01,440 SO THIS TYPE OF FRAMEWORK IS 191 00:12:01,440 --> 00:12:03,440 USEFUL TO MAP BRAIN DEVELOPMENT 192 00:12:03,440 --> 00:12:05,320 AND AGING SO WE CAN BETTER 193 00:12:05,320 --> 00:12:07,440 UNDERSTAND DISEASE AND COMPARE 194 00:12:07,440 --> 00:12:09,680 ACROSS DIFFERENT CLINICAL 195 00:12:09,680 --> 00:12:11,800 CONDITIONS AND THE PRECEDENT 196 00:12:11,800 --> 00:12:13,560 HERE IS STAGGERING WITH ALL OF 197 00:12:13,560 --> 00:12:15,480 THE AVAILABLE RESEARCH DATASETS 198 00:12:15,480 --> 00:12:17,560 AND SOME OF WHICH ARE LISTED 199 00:12:17,560 --> 00:12:19,680 ABOVE AND CLINICALLY SCANNING IN 200 00:12:19,680 --> 00:12:22,040 THESE VULNERABLE POPULATIONS IN 201 00:12:22,040 --> 00:12:24,160 KIDS UNDER FIVE ON THE RIGHT AND 202 00:12:24,160 --> 00:12:28,000 ADULTS OVER 65 IS STEADILY 203 00:12:28,000 --> 00:12:30,840 INCREASING. 204 00:12:30,840 --> 00:12:34,280 ABOUT 3% YEAR ON YEAR GROWTH. 205 00:12:34,280 --> 00:12:38,480 THAT IS OVER 10 MILLION MRI 206 00:12:38,480 --> 00:12:40,400 SCANS JUST BEING DONE IN THE 207 00:12:40,400 --> 00:12:45,200 U.S. AND THAT IS FROM 2019-2020. 208 00:12:45,200 --> 00:12:47,880 SO THIS DATA EVEN IF YOU WANT TO 209 00:12:47,880 --> 00:12:50,160 FIND THEM AND WITH AMAZING TOOLS 210 00:12:50,160 --> 00:12:51,840 THAT EXIST IN OUR COMMUNITY FOR 211 00:12:51,840 --> 00:12:54,280 HOW TO ORGANIZE DATA AND SHARE 212 00:12:54,280 --> 00:12:57,600 DATA STILL YOU HAVE TO LOOK IN 213 00:12:57,600 --> 00:13:03,360 MANY APPLICATIONS. 214 00:13:03,360 --> 00:13:05,160 BUT THIS IS HIGHLIGHTING A FEW 215 00:13:05,160 --> 00:13:06,640 RESOURCES BUT WE OURSELVES 216 00:13:06,640 --> 00:13:09,080 ACCESS SOME DATA AND SOME OF THE 217 00:13:09,080 --> 00:13:11,560 PROTOCOLS TO HELP FACILITATE 218 00:13:11,560 --> 00:13:13,960 DATA SHARING AND DATA ACCESS. 219 00:13:13,960 --> 00:13:16,640 SO OUR PROJECT BRIEFLY A FEW 220 00:13:16,640 --> 00:13:18,040 DIFFERENT GOALS. 221 00:13:18,040 --> 00:13:21,000 ONE WAS ON THE SCIENTIFIC SIDE. 222 00:13:21,000 --> 00:13:27,160 TO MAP POPULATION LEVEL, 223 00:13:27,160 --> 00:13:31,000 TRAJECTORY TO DEFINE MILESTONES 224 00:13:31,000 --> 00:13:32,920 OF BRAIN GROWTH AND MAKE THIS 225 00:13:32,920 --> 00:13:34,920 TOOL AVAILABLE FOR PEOPLE WITH 226 00:13:34,920 --> 00:13:36,920 DATASETS OF THEIR OWN THAT WERE 227 00:13:36,920 --> 00:13:38,840 NOT INCLUDED IN THE ORIGINAL 228 00:13:38,840 --> 00:13:41,800 STUDY AND BECAUSE A LOT OF 229 00:13:41,800 --> 00:13:44,040 DATASETS ARE CASE CONTROL IN 230 00:13:44,040 --> 00:13:47,000 DESIGN WE WANTED TO PROVIDE 231 00:13:47,000 --> 00:13:48,560 STANDARDIZED EFFECT SIZES FOR 232 00:13:48,560 --> 00:13:50,120 PATIENT POPULATIONS WITH 233 00:13:50,120 --> 00:13:52,000 SUFFICIENT SAMPLE SIZES AND WE 234 00:13:52,000 --> 00:13:55,000 WANTED TO MAKE THE DATA ACCESS 235 00:13:55,000 --> 00:13:57,960 FOR OTHER RESEARCHERS MORE 236 00:13:57,960 --> 00:14:03,440 ACCESSIBLE. 237 00:14:03,440 --> 00:14:06,040 AND THIS IS THE BASIC IDEA. 238 00:14:06,040 --> 00:14:07,960 TAKE THE BRAIN SCAN AND DISSECT 239 00:14:07,960 --> 00:14:10,400 IT AND WE CAN DO THAT ACROSS THE 240 00:14:10,400 --> 00:14:11,880 ENTIRE POPULATION OF DATA THAT 241 00:14:11,880 --> 00:14:15,840 WE HAVE AND USE SOME GROWTH 242 00:14:15,840 --> 00:14:17,760 MODELING TO BE ABLE TO PROVIDE 243 00:14:17,760 --> 00:14:22,480 THESE DIFFERENT CURVES FOR SOME 244 00:14:22,480 --> 00:14:24,280 TILES AS YOU WOULD FOR BREATHE 245 00:14:24,280 --> 00:14:25,000 POPULATION CHARTS. 246 00:14:25,000 --> 00:14:31,920 OUR SAMPLE WAS ABOUT 125,000 247 00:14:31,920 --> 00:14:32,560 SCANS. 248 00:14:32,560 --> 00:14:36,600 WE ACCESS DATA FROM ACROSS THE 249 00:14:36,600 --> 00:14:39,600 ENTIRE MRI LIFE-SPAN SOEVER 250 00:14:39,600 --> 00:14:41,800 SINCE MRI CAME ON-LINE AT SCALE 251 00:14:41,800 --> 00:14:47,680 IN THE EARLY '90s UP TO A FEW 252 00:14:47,680 --> 00:14:53,840 YEARS AGO MEANING 115 DAYS POST 253 00:14:53,840 --> 00:14:55,280 CONCEPTION DIFFERENT SITES AND 254 00:14:55,280 --> 00:14:57,680 SCANNERS AND MASSIVELY GLOBAL. 255 00:14:57,680 --> 00:14:59,400 NOT FULLY POPULATION 256 00:14:59,400 --> 00:15:00,960 REPRESENTATIVE AND ACROSS 257 00:15:00,960 --> 00:15:02,800 DIFFERENT CLINICAL CONDITIONS. 258 00:15:02,800 --> 00:15:05,800 THESE DATASETS WERE RANGING IN 259 00:15:05,800 --> 00:15:08,920 TERMS OF SHAREABILITY AND 260 00:15:08,920 --> 00:15:12,400 OBVIOUSLY REQUIRED A TON OF 261 00:15:12,400 --> 00:15:13,040 COMPUTE TIME. 262 00:15:13,040 --> 00:15:15,400 WE TAKE A SCAN AND BREAK IT DOWN 263 00:15:15,400 --> 00:15:18,760 INTO DIFFERENT PIECES AND USE A 264 00:15:18,760 --> 00:15:21,520 STATISTICAL FRAMEWORK TO ASK THE 265 00:15:21,520 --> 00:15:23,640 QUESTION OF HOW BIG IS THIS 266 00:15:23,640 --> 00:15:26,520 BRAIN REGION FOR EXAMPLE 267 00:15:26,520 --> 00:15:33,240 RELATIVE TO OTHER PEERS OF THAT 268 00:15:33,240 --> 00:15:36,840 INDIVIDUAL AND WE CAN LOOK FOR 269 00:15:36,840 --> 00:15:39,720 DETAILS AS BEST AS POSSIBLE. 270 00:15:39,720 --> 00:15:46,080 AND THESE ARE THE RAW VALUES OF 271 00:15:46,080 --> 00:15:48,000 BRAIN STRUCTURE AND THE RAW DATA 272 00:15:48,000 --> 00:15:52,160 IS ON TOP. 273 00:15:52,160 --> 00:15:59,520 THAND THE NORMATIVE VARIANTS. 274 00:15:59,520 --> 00:16:01,960 THE DIFFERENCE ACROSS THE 275 00:16:01,960 --> 00:16:04,080 POPULATION IN MAGNITUDE ACROSS 276 00:16:04,080 --> 00:16:05,840 THESE DIFFERENT FEATURES ARE 277 00:16:05,840 --> 00:16:09,120 MAPPED ACROSS THE LIFE-SPAN. 278 00:16:09,120 --> 00:16:13,320 AND WE CAN MAP THE PACE OR THE 279 00:16:13,320 --> 00:16:13,760 VELOCITY. 280 00:16:13,760 --> 00:16:16,960 WE CAN DO THIS FOR GLOBAL 281 00:16:16,960 --> 00:16:19,320 FEATURES AND ALSO FOR DIFFERENT 282 00:16:19,320 --> 00:16:22,200 LOCAL FEATURES, BRAIN VOLUMES 283 00:16:22,200 --> 00:16:24,720 FOR REGIONS IN THE CORTEX AND 284 00:16:24,720 --> 00:16:27,400 THE SUB CORTEZ AND THIS IS 285 00:16:27,400 --> 00:16:28,520 HIGHLIGHTING THE RANGE AND 286 00:16:28,520 --> 00:16:30,520 DEVELOPMENT FOR THE TWO EXTREME 287 00:16:30,520 --> 00:16:39,240 FEATURES IN TERMS OF WHEN THEY 288 00:16:39,240 --> 00:16:41,880 PEAK IN OVER-ALL SIZE. 289 00:16:41,880 --> 00:16:44,360 HERE MAPPING THE PERCENTAGE OF 290 00:16:44,360 --> 00:16:46,280 TOTAL MAXIMUM SIZE FOR EACH OF 291 00:16:46,280 --> 00:16:48,920 THE DIFFERENT FEATURES SO WE CAN 292 00:16:48,920 --> 00:16:51,600 USE THESE TYPES OF PLOTS TO MAP 293 00:16:51,600 --> 00:16:53,640 DIFFERENT PHASES OF DEVELOPMENT. 294 00:16:53,640 --> 00:16:55,200 TIMES WHEN THESE FEATURES ARE 295 00:16:55,200 --> 00:16:57,320 CHANGING MOST VERSUS CHANGING 296 00:16:57,320 --> 00:16:57,760 LEAST. 297 00:16:57,760 --> 00:17:01,720 WHEN THEY ARE COLLECTIVELY 298 00:17:01,720 --> 00:17:04,720 CHANGING VERSUS DIVERGING. 299 00:17:04,720 --> 00:17:07,040 TO BE ABLE TO BETTER UNDERSTAND 300 00:17:07,040 --> 00:17:10,160 AND MAP OUT IDEAL MILESTONES OR 301 00:17:10,160 --> 00:17:13,280 IDEAL PERIODS TO QUERY 302 00:17:13,280 --> 00:17:14,800 INDIVIDUALS ESPECIALLY FOR 303 00:17:14,800 --> 00:17:16,240 LONGITUDINAL DESIGN. 304 00:17:16,240 --> 00:17:18,760 AND OUR VISION FOR THIS WORK IS 305 00:17:18,760 --> 00:17:19,200 MULTI-FOLD. 306 00:17:19,200 --> 00:17:23,760 THIS IS MY FELLOW FIRST 307 00:17:23,760 --> 00:17:26,920 CO-AUTHOR RICHARD BETHLEHEM 308 00:17:26,920 --> 00:17:28,400 QUERYING OUR ON-LINE TOOL THAT 309 00:17:28,400 --> 00:17:30,240 IS AVAILABLE TO ANYONE WHERE IT 310 00:17:30,240 --> 00:17:33,240 REQUIRES A BASIC SPREADSHEET 311 00:17:33,240 --> 00:17:36,240 WITH PROCESS DATA AND YOU CAN 312 00:17:36,240 --> 00:17:38,120 CONVERT THESE QUANTITIES THESE 313 00:17:38,120 --> 00:17:41,800 BRAIN METRICS THAT ARE DRIVABLE 314 00:17:41,800 --> 00:17:43,840 FROM MULTIPLE PIPELINES AND 315 00:17:43,840 --> 00:17:46,000 CONVERT THEM TO THESE SCORES. 316 00:17:46,000 --> 00:17:48,880 YOU CAN VISUALIZE YOUR OUTPUT. 317 00:17:48,880 --> 00:17:49,640 DOWNLOAD RESULTS. 318 00:17:49,640 --> 00:17:52,200 YOU CAN EXPLORE THE ENTIRE 319 00:17:52,200 --> 00:17:53,560 DATASET. 320 00:17:53,560 --> 00:17:55,560 AND WE HOPE THIS IS JUST A START 321 00:17:55,560 --> 00:17:58,000 TO PROVIDE MORE OF A SUSTAINABLE 322 00:17:58,000 --> 00:17:59,360 DEVELOPMENT IN THE FUTURE. 323 00:17:59,360 --> 00:18:01,600 AND AS I SAID SOME OF THE POWER 324 00:18:01,600 --> 00:18:04,720 OF THE IMAGING IS UNLOCKED ONCE 325 00:18:04,720 --> 00:18:07,640 YOU'VE NORMALIZED YOUR DATA AND 326 00:18:07,640 --> 00:18:09,840 PROVIDED BENCHMARKS RELATIVE TO 327 00:18:09,840 --> 00:18:12,480 A MUCH LARGER DATASET. 328 00:18:12,480 --> 00:18:14,560 YOU CAN LEVERAGE STUDIES THAT 329 00:18:14,560 --> 00:18:17,240 ARE MORE DEEPLY PHENOTYPED 330 00:18:17,240 --> 00:18:18,720 WITHIN INDIVIDUALS AND YOU CAN 331 00:18:18,720 --> 00:18:22,360 USE MRI AS ROBUST END POINTS 332 00:18:22,360 --> 00:18:24,440 WHETHER FOR PREDICTION IF YOU'RE 333 00:18:24,440 --> 00:18:27,200 LOOKING EARLY OR PRETREATMENT OR 334 00:18:27,200 --> 00:18:29,720 USING THEM AS END POINTS TO LOOK 335 00:18:29,720 --> 00:18:32,720 AT OUTCOMES. 336 00:18:32,720 --> 00:18:35,960 RESULTS OF AN IMAGING GENETIC 337 00:18:35,960 --> 00:18:38,960 STUDY OR COMPARING TO ASPECT OF 338 00:18:38,960 --> 00:18:41,000 BEHAVIOR AND COGNITION ETC. 339 00:18:41,000 --> 00:18:43,320 SO WITH THAT THE MAIN LESSONS 340 00:18:43,320 --> 00:18:47,440 THAT WE REALLY LEARNED THIS IS 341 00:18:47,440 --> 00:18:50,280 THREE OF MANY THE FIRST TWO ARE 342 00:18:50,280 --> 00:18:51,960 LINKED TO EACH OTHER IN THAT 343 00:18:51,960 --> 00:18:55,920 DATA SHARING AND REUSE ARE 344 00:18:55,920 --> 00:18:59,800 RESEARCH INTENSIVE. 345 00:18:59,800 --> 00:19:03,600 INHERENTLY COLLABORATIVE 346 00:19:03,600 --> 00:19:04,920 ENDEAVORS. 347 00:19:04,920 --> 00:19:08,040 IT ENDS UP AS A PUBLICATION OR 348 00:19:08,040 --> 00:19:11,120 PRODUCT AND THERE ARE SOME 349 00:19:11,120 --> 00:19:14,880 HIGHLIGHTED AN CITY LARRY 350 00:19:14,880 --> 00:19:16,200 PUBLICATIONS TO OURSELVES. 351 00:19:16,200 --> 00:19:17,200 *. 352 00:19:17,200 --> 00:19:21,720 AND DATA REPURPOSING IN A GLOBAL 353 00:19:21,720 --> 00:19:23,920 SENSE REQUIRES PEOPLE WITH 354 00:19:23,920 --> 00:19:27,560 VARYING EXPERTISE AND THAT IS 355 00:19:27,560 --> 00:19:29,760 INTIMIDATING TO EARLY STAGE 356 00:19:29,760 --> 00:19:31,480 RESEARCHERS BUT MOST OF THESE 357 00:19:31,480 --> 00:19:33,480 THINGS CAN BE INITIATED WITH 358 00:19:33,480 --> 00:19:35,200 GOOD MENTORSHIP FROM PEOPLE IN 359 00:19:35,200 --> 00:19:36,560 THE TRAINING PROCESS. 360 00:19:36,560 --> 00:19:39,240 I WAS A POSTDOC AT THE TIME OF 361 00:19:39,240 --> 00:19:40,040 STARTING THIS PROJECT FOR 362 00:19:40,040 --> 00:19:41,240 EXAMPLE. 363 00:19:41,240 --> 00:19:45,240 AND MORE GENERALLY WE DEFINITELY 364 00:19:45,240 --> 00:19:48,000 RAN INTO THIS PROBLEM OF THE 365 00:19:48,000 --> 00:19:49,040 POPULATION REFERENCE AND THE 366 00:19:49,040 --> 00:19:51,680 LACK OF EQUITY AND IT COMES WITH 367 00:19:51,680 --> 00:19:53,480 THE FIRST TWO POINTS. 368 00:19:53,480 --> 00:19:56,240 WE HAD ACCESS TO FREE COMPUTES 369 00:19:56,240 --> 00:19:59,480 AT OUR UNIVERSITIES AND DATA 370 00:19:59,480 --> 00:20:01,800 STORAGE, LEGAL ACCESS FOR DATA 371 00:20:01,800 --> 00:20:04,280 SHARING AND SO OPEN SCIENCE OUR 372 00:20:04,280 --> 00:20:06,160 EFFORTS ARE AMAZING AT 373 00:20:06,160 --> 00:20:08,360 INCREASING EQUITY IN TERMS OF 374 00:20:08,360 --> 00:20:11,400 THE DEMOCRITAZTION OF ACCESS AND 375 00:20:11,400 --> 00:20:13,040 RESOURCES BUT THEY ARE JUST THE 376 00:20:13,040 --> 00:20:14,960 FIRST STEP IN A LARGER 377 00:20:14,960 --> 00:20:16,520 SCIENTIFIC PROBLEM FOR 378 00:20:16,520 --> 00:20:18,960 INCREASING THE GLOBAL 379 00:20:18,960 --> 00:20:20,000 REPRESENTATIVENESS OF THE 380 00:20:20,000 --> 00:20:21,920 DATASETS THAT ARE BEING SHARED 381 00:20:21,920 --> 00:20:23,840 AND SO WITH THAT I WOULD LIKE TO 382 00:20:23,840 --> 00:20:28,160 THANK THE CO-AUTHORS OF THE 383 00:20:28,160 --> 00:20:29,960 PAPER AND FOR ALL OF YOU FOR 384 00:20:29,960 --> 00:20:36,720 YOUR ATTENTION. 385 00:20:36,720 --> 00:20:39,240 >>THANK YOU SO MUCH, JAKOB. 386 00:20:39,240 --> 00:20:43,960 OUR NEXT SPEAKER IS FROM THE 387 00:20:43,960 --> 00:20:45,440 JOHN HOPKINS UNIVERSITY AND 388 00:20:45,440 --> 00:20:47,600 YOU'RE ALSO GOING TO SPEAK ABOUT 389 00:20:47,600 --> 00:20:49,600 USING PUBLIC DATA TO GENERATE 390 00:20:49,600 --> 00:20:56,160 NEW DISCOVERIES SO OVER TO YOU 391 00:20:56,160 --> 00:21:00,400 DR. FARIA. 392 00:21:00,400 --> 00:21:01,600 >>HI. 393 00:21:01,600 --> 00:21:06,120 LET ME SHARE MY SCREEN. 394 00:21:06,120 --> 00:21:08,880 CAN YOU SEE MY SCREEN? 395 00:21:08,880 --> 00:21:09,960 >>YES. 396 00:21:09,960 --> 00:21:10,360 LOOKS GREAT. 397 00:21:10,360 --> 00:21:11,080 THANK YOU SO MUCH. 398 00:21:11,080 --> 00:21:13,040 >>THANK YOU FOR THE INVITATION 399 00:21:13,040 --> 00:21:17,760 TO TALK TODAY AND I'M GOING TO 400 00:21:17,760 --> 00:21:21,520 TALK ABOUT THE FAIR ANNOTATED 401 00:21:21,520 --> 00:21:25,480 DATA OF STROKE MRI'S AND 402 00:21:25,480 --> 00:21:32,320 METADATA. 403 00:21:32,320 --> 00:21:42,440 SO AS YOU KNOW STROKE IS HUGELY 404 00:21:42,440 --> 00:21:46,120 IMPORTANT FROM BOTH RESEARCH AND 405 00:21:46,120 --> 00:21:56,400 CLINICAL POINTS. 406 00:21:58,040 --> 00:22:02,720 WE CAN USE THIS QUANTITATIVE AND 407 00:22:02,720 --> 00:22:06,160 OBJECTIVE INFORMATION TO GUIDE 408 00:22:06,160 --> 00:22:08,400 CLINICAL TRIALS OR DECISIONS 409 00:22:08,400 --> 00:22:11,520 ABOUT TREATMENT OR EVEN TO 410 00:22:11,520 --> 00:22:15,520 CREATE TOOLS TO BE SECOND 411 00:22:15,520 --> 00:22:18,160 FEEDERS. 412 00:22:18,160 --> 00:22:24,480 PATIENT EDUCATION ETC. 413 00:22:24,480 --> 00:22:26,800 WE HAVE RESEARCH IN THESE 414 00:22:26,800 --> 00:22:28,800 STUDIES THAT LEAD TO MOST OF THE 415 00:22:28,800 --> 00:22:30,440 KNOWLEDGE IN NEURO SIGH THANS WE 416 00:22:30,440 --> 00:22:37,400 HAVE TODAY AND WE MOVED FROM THE 417 00:22:37,400 --> 00:22:40,680 ADOPTIVE EXPERIENCES TO DATA 418 00:22:40,680 --> 00:22:41,440 SUPPORTED EVIDENCE. 419 00:22:41,440 --> 00:22:43,000 AND THAT IS THE SOLUTION AND THE 420 00:22:43,000 --> 00:22:43,680 PROBLEM. 421 00:22:43,680 --> 00:22:46,200 SO WE NEED LARGE AMOUNT OF DATA 422 00:22:46,200 --> 00:22:56,720 TO STUDY STROKES AS WELL AS -- 423 00:22:58,360 --> 00:23:03,800 DATA IMAGING AND METADATA. 424 00:23:03,800 --> 00:23:07,440 IT HAS -- IT IMPOSE NEW 425 00:23:07,440 --> 00:23:10,600 CHALLENGE TO DATA SHARING. 426 00:23:10,600 --> 00:23:12,680 BUT WE ARE ABOUT TO OVERCOME 427 00:23:12,680 --> 00:23:15,480 SOME OF THIS CHALLENGE SHARING 428 00:23:15,480 --> 00:23:19,120 THE FIRST LARGE DATASET OF 429 00:23:19,120 --> 00:23:22,560 CLINICAL STROKES CLINICAL 430 00:23:22,560 --> 00:23:28,240 ACCUSED AND STROKES AND THE 431 00:23:28,240 --> 00:23:31,040 DESIGN IS THAT WE TEAM UP WITH 432 00:23:31,040 --> 00:23:36,000 OUR RESEARCH CENTER SO WHENEVER 433 00:23:36,000 --> 00:23:41,760 PATIENTS WERE SCANNED WITH 434 00:23:41,760 --> 00:23:44,120 STROKE SYMPTOMS WE TRANSFER 435 00:23:44,120 --> 00:23:49,840 THEIR IMAGE DATA AND ANNOTATE IT 436 00:23:49,840 --> 00:23:53,840 AND THEN WE GOT THE STRUCTURAL 437 00:23:53,840 --> 00:23:56,240 INFORMATION, THE METADATA 438 00:23:56,240 --> 00:23:59,240 INFORMATION ABOUT DEMOGRAPHICS 439 00:23:59,240 --> 00:24:06,040 ABOUT CLINICAL FILE. 440 00:24:06,040 --> 00:24:12,520 AND WE ORGANIZE IT ALL FOR BITS 441 00:24:12,520 --> 00:24:16,120 AND GUIDELINES AND WE MAKE IT 442 00:24:16,120 --> 00:24:17,560 PUBLICLY AVAILABLE AS I'M GOING 443 00:24:17,560 --> 00:24:19,240 TO SHOW YOU NEXT. 444 00:24:19,240 --> 00:24:20,760 AND WHAT IS THE IMPORTANCE OF 445 00:24:20,760 --> 00:24:21,280 THIS? 446 00:24:21,280 --> 00:24:23,840 THE IMPORTANCE IS THAT WE CAN 447 00:24:23,840 --> 00:24:27,720 GENERATE FEATURE FACTORS OR 448 00:24:27,720 --> 00:24:29,640 COMPUTABLE OBJECTS. 449 00:24:29,640 --> 00:24:33,520 REVEALING HOW DIFFERENT LESIONS 450 00:24:33,520 --> 00:24:36,800 AFFECT DIFFERENT REGIONS OF THE 451 00:24:36,800 --> 00:24:38,800 BRAIN AND THIS IS POWERFUL FOR 452 00:24:38,800 --> 00:24:41,240 RESEARCHERS IN DIFFERENT FIELDS. 453 00:24:41,240 --> 00:24:42,920 FOR INSTANCE CLINICIANS OR 454 00:24:42,920 --> 00:24:44,200 CLINICAL RESEARCHERS CAN 455 00:24:44,200 --> 00:24:46,440 DIRECTLY USE THIS DATA IN THEIR 456 00:24:46,440 --> 00:24:49,720 LESION BASED STUDIES OR TO GUIDE 457 00:24:49,720 --> 00:24:51,720 CLINICAL DECISIONS LONG-TERM. 458 00:24:51,720 --> 00:24:59,200 AND BIOMEDICAL ENGINEER AND 459 00:24:59,200 --> 00:25:00,400 TRANSLATION RESEARCHERS CAN USE 460 00:25:00,400 --> 00:25:02,320 THIS DATA TO DEVELOP FOR 461 00:25:02,320 --> 00:25:05,680 INSTANCE NEW TOOLS FOR STROKE 462 00:25:05,680 --> 00:25:06,960 ANALYSIS AND QUANTIFICATION. 463 00:25:06,960 --> 00:25:08,760 HERE IS WHERE WE ARE NOW. 464 00:25:08,760 --> 00:25:16,320 SO WE SHARED THESE ALMOST 3,000 465 00:25:16,320 --> 00:25:20,760 PATIENTS WITH THE IMAGE AND THE 466 00:25:20,760 --> 00:25:22,800 METADATA OF THESE PATIENTS. 467 00:25:22,800 --> 00:25:25,080 THERE ARE LESIONS IN DIFFERENT 468 00:25:25,080 --> 00:25:26,680 REGIONS OF THE BRAIN. 469 00:25:26,680 --> 00:25:28,360 DIFFERENT TYPES OF STROKES AND 470 00:25:28,360 --> 00:25:30,600 WE SHARE NOT ONLY THE RAW DATA 471 00:25:30,600 --> 00:25:33,720 BUT ALSO THE IMAGE ANNOTATED, 472 00:25:33,720 --> 00:25:36,160 THE STROKE MASK AND THE BRAIN 473 00:25:36,160 --> 00:25:41,160 MASK AND THE IMAGE IN COMMON -- 474 00:25:41,160 --> 00:25:43,680 COORDINATES AND IMAGE ANALYSIS. 475 00:25:43,680 --> 00:25:48,440 SO WE CAN EXPENSE DATA USAGE AND 476 00:25:48,440 --> 00:25:51,320 STRUCTURE THE METADATA 477 00:25:51,320 --> 00:25:52,760 DEMOGRAPHIC AND CLINICAL 478 00:25:52,760 --> 00:25:57,560 INFORMATION. 479 00:25:57,560 --> 00:26:02,520 WE SHARE THIS IN THE 480 00:26:02,520 --> 00:26:04,640 PROFESSIONAL REPOSITORY. 481 00:26:04,640 --> 00:26:08,840 WE USE THE ICPSR. 482 00:26:08,840 --> 00:26:12,680 ONE OF THE GOOD POINTS ABOUT 483 00:26:12,680 --> 00:26:16,160 SHARING THESE IN THE THIRD PART 484 00:26:16,160 --> 00:26:19,880 REPOSITORY IS THAT IT ALLEVIATES 485 00:26:19,880 --> 00:26:22,880 THE BURDEN THAT SOMETIMES THE 486 00:26:22,880 --> 00:26:24,440 RESEARCHERS UNDERSTAND ESTIMATE 487 00:26:24,440 --> 00:26:28,720 THE BURDEN OF DATA CREATION AND 488 00:26:28,720 --> 00:26:33,440 DATA MAINTENANCE AND ALSO IT 489 00:26:33,440 --> 00:26:35,760 GIVES THE PROFILES ABOUT DATA 490 00:26:35,760 --> 00:26:38,120 USAGE THAT ARE VERY IMPORTANT TO 491 00:26:38,120 --> 00:26:41,600 TRACK YOUR DATA SHARING. 492 00:26:41,600 --> 00:26:43,640 AND HERE I WOULD LIKE TO SHOW 493 00:26:43,640 --> 00:26:47,800 YOU SOME OF THE APPLICATIONS 494 00:26:47,800 --> 00:26:49,360 THAT WE AND OTHERS ARE USING 495 00:26:49,360 --> 00:26:50,760 THIS DATA FOR. 496 00:26:50,760 --> 00:26:58,600 SO HERE IS THE ARTERIAL 497 00:26:58,600 --> 00:27:01,400 TERRITORIES BRAIN ATLAS WITH 498 00:27:01,400 --> 00:27:05,440 MORE THAN 1300 LESION MARKS. 499 00:27:05,440 --> 00:27:07,960 THIS IS A DIGITAL ATLAS. 500 00:27:07,960 --> 00:27:09,720 THE FIRST EVER AVAILABLE. 501 00:27:09,720 --> 00:27:13,960 WE ALSO FREELY SHARE THESE TOOLS 502 00:27:13,960 --> 00:27:16,920 IN METRIC AND AS YOU CAN SEE WE 503 00:27:16,920 --> 00:27:19,080 ARE RECEIVED BY THE COMMUNITY 504 00:27:19,080 --> 00:27:22,920 BECAUSE NOW PEOPLE ANYONE CAN GO 505 00:27:22,920 --> 00:27:27,000 THERE, DOWNLOAD AND CHECK LESION 506 00:27:27,000 --> 00:27:29,120 LOADS AND OTHER FEATURES IN EACH 507 00:27:29,120 --> 00:27:31,240 BRAIN. 508 00:27:31,240 --> 00:27:36,240 WE DEVELOP ACCESSES BASED ON 509 00:27:36,240 --> 00:27:38,680 STROKE ANALYSIS AND NOW THAT WE 510 00:27:38,680 --> 00:27:40,080 KNOW WHERE DIFFERENT STRUCTURES 511 00:27:40,080 --> 00:27:42,480 OF THE BRAIN ARE WE ALSO NEEDED 512 00:27:42,480 --> 00:27:47,880 TO KNOW WHERE THE STROKE WAS IN 513 00:27:47,880 --> 00:27:57,280 A QUANTITATIVE AUTOMATIC WAY. 514 00:27:57,280 --> 00:27:59,800 SO USING THE DATASET WE CREATED 515 00:27:59,800 --> 00:28:04,760 A MODEL FOR STROKE DETECTION AND 516 00:28:04,760 --> 00:28:06,640 SEGMENTATION THAT UTILIZE 517 00:28:06,640 --> 00:28:12,160 TRADITIONAL MACHINE LEARNING AND 518 00:28:12,160 --> 00:28:14,720 AS YOU CAN SEE WE WERE ABLE TO 519 00:28:14,720 --> 00:28:18,120 CREATE MODELS OR CREATE THE 520 00:28:18,120 --> 00:28:26,720 AGENTS THAT ARE PRETTY CLOSE TO 521 00:28:26,720 --> 00:28:30,840 MONO DELINEATION. 522 00:28:30,840 --> 00:28:32,400 THIS IS SAYING WHERE THE STROKE 523 00:28:32,400 --> 00:28:36,360 IS AND WHERE DIFFERENT VISIONS 524 00:28:36,360 --> 00:28:38,640 OF THE BRAIN WERE SO WE CAN 525 00:28:38,640 --> 00:28:40,520 TRANSFORM THIS DATA INTO NUMBERS 526 00:28:40,520 --> 00:28:43,160 WHICH I'M CALLING COMPUTABLE 527 00:28:43,160 --> 00:28:46,800 DATA OBJECTS AND WITH THESE 528 00:28:46,800 --> 00:28:54,720 NUMBERS WE COULD USE IT IN A 529 00:28:54,720 --> 00:28:56,560 MUCH MORE FRIENDLY WAY. 530 00:28:56,560 --> 00:28:59,120 TO CALCULATE INCHES OF CLINICAL 531 00:28:59,120 --> 00:29:04,600 RELEVANCE OR TO DO REPORTS OR TO 532 00:29:04,600 --> 00:29:06,600 DO LESION BASE STUDIES. 533 00:29:06,600 --> 00:29:09,040 HERE ARE SOME OF THE EXAMPLES. 534 00:29:09,040 --> 00:29:11,720 SO ONE OF OUR FIRST APPLICATIONS 535 00:29:11,720 --> 00:29:14,440 WAS TO USE THIS QUANTITATIVE 536 00:29:14,440 --> 00:29:19,600 FEATURE FACTOR SAYING WHICH 537 00:29:19,600 --> 00:29:23,640 REGIONS ARE ORIGINATED BY THIS 538 00:29:23,640 --> 00:29:26,200 STROKE. 539 00:29:26,200 --> 00:29:29,360 TO CREATE ATLAS SCORES. 540 00:29:29,360 --> 00:29:31,240 PEOPLE THAT ARE NOT FAMILIAR 541 00:29:31,240 --> 00:29:35,120 WITH STROKE, USE IT IN CLINICAL 542 00:29:35,120 --> 00:29:37,440 ANALYSIS THAT KEEPS YOU WHICH 543 00:29:37,440 --> 00:29:39,440 REGIONS ARE AFFECTED BY THE 544 00:29:39,440 --> 00:29:41,880 STROKE AND THEN WE CAN MODEL 545 00:29:41,880 --> 00:29:45,440 YOUR PROGNOSIS OR THINK ABOUT 546 00:29:45,440 --> 00:29:46,080 ACTUAL TREATMENT. 547 00:29:46,080 --> 00:29:52,480 SO WE USE IT -- THIS DATA TO 548 00:29:52,480 --> 00:29:54,280 TRAIN MACHINE LEARNING MODELS 549 00:29:54,280 --> 00:29:57,880 AND CALCULATE SCORES AND WE NOT 550 00:29:57,880 --> 00:29:59,680 ONLY DELIVER THIS COURSE BUT 551 00:29:59,680 --> 00:30:02,800 ALSO THE COMPREHENSIVE FEATURES 552 00:30:02,800 --> 00:30:05,360 THAT WERE USED ON THESE MODELS 553 00:30:05,360 --> 00:30:07,760 TO ARRIVE ON THESE OUTPUTS. 554 00:30:07,760 --> 00:30:10,160 SO THESE ARE COMPREHENSIVE 555 00:30:10,160 --> 00:30:11,960 MODELS WHICH ARE VERY WELL 556 00:30:11,960 --> 00:30:13,520 RECEIVED IN THE CLINICAL 557 00:30:13,520 --> 00:30:14,920 COMMUNITY. 558 00:30:14,920 --> 00:30:18,360 AND FOLLOWING THIS SAME 559 00:30:18,360 --> 00:30:20,640 REASONING WE ALSO CALCULATED 560 00:30:20,640 --> 00:30:23,280 FEATURE FACTORS BASED ON WHOLE 561 00:30:23,280 --> 00:30:24,880 BRAIN SEGMENTATION AND WE WERE 562 00:30:24,880 --> 00:30:32,560 ABLE TO PRODUCE REPORTS 563 00:30:32,560 --> 00:30:34,800 AUTOMATED REGIONAL REPORTS THAT 564 00:30:34,800 --> 00:30:38,640 AGREE VASTLY WITH REGIONAL 565 00:30:38,640 --> 00:30:38,880 REPORTS. 566 00:30:38,880 --> 00:30:42,800 THIS IS IN AGREEMENT WITH WHAT I 567 00:30:42,800 --> 00:30:45,680 THINK HAS TO BE ONE OF THE MAIN 568 00:30:45,680 --> 00:30:49,840 GOALS IN ARTIFICIAL INTELLIGENCE 569 00:30:49,840 --> 00:30:52,280 APPLICATIONS IN HEALTH 570 00:30:52,280 --> 00:30:57,240 CONDITIONS. 571 00:30:57,240 --> 00:31:00,880 THIS CANNOT BE SUPER USEFUL IN A 572 00:31:00,880 --> 00:31:02,760 VERY BIG CENTER BUT IT CAN ACT 573 00:31:02,760 --> 00:31:07,120 AS A SECOND FEEDER OR A FLAG IN 574 00:31:07,120 --> 00:31:11,360 THE CENTER. 575 00:31:11,360 --> 00:31:14,640 IT ALSO PRODUCED NUMBERS 576 00:31:14,640 --> 00:31:18,160 QUANTITATIVE NUMBERS. 577 00:31:18,160 --> 00:31:21,360 THAT SAVE US THE BURDEN AND THE 578 00:31:21,360 --> 00:31:26,240 TIME TO GO THERE AND TO USE THIS 579 00:31:26,240 --> 00:31:28,440 TO DO YOUR CLINICAL PLANNING OR 580 00:31:28,440 --> 00:31:29,280 YOUR RESEARCH. 581 00:31:29,280 --> 00:31:32,560 . 582 00:31:32,560 --> 00:31:36,480 AND ALSO THIS IS FREE AND 583 00:31:36,480 --> 00:31:37,080 PUBLIC. 584 00:31:37,080 --> 00:31:38,960 ANYONE CAN GO THERE AND DOWNLOAD 585 00:31:38,960 --> 00:31:41,920 THIS TECHNOLOGY. 586 00:31:41,920 --> 00:31:45,600 AND CAN IT'S VERY USER-FRIENDLY 587 00:31:45,600 --> 00:31:47,720 SO YOU CAN RUN THIS PROCESS IN 588 00:31:47,720 --> 00:31:53,440 YOUR CPU WITH ONE COMMON LINE 589 00:31:53,440 --> 00:31:55,760 AND YOU CAN GET THE REPORTS OF 590 00:31:55,760 --> 00:31:59,240 QUANTITATIVE FEATURE FACTORS AND 591 00:31:59,240 --> 00:32:06,760 ALSO IF YOU WANT OTHER TYPES OF 592 00:32:06,760 --> 00:32:08,680 MEDICAL AND CLINICAL RESEARCH 593 00:32:08,680 --> 00:32:09,720 REPORTS. 594 00:32:09,720 --> 00:32:13,720 I'M GOING TO GO QUICKLY ABOUT 595 00:32:13,720 --> 00:32:24,160 OUR INITIAL APPLICATIONS. 596 00:32:32,480 --> 00:32:42,880 AND THE MEASURES OR DO THE MORE 597 00:32:42,880 --> 00:32:46,400 TRADITIONAL LESION BASED STUDIES 598 00:32:46,400 --> 00:32:51,120 CORRELATING THEM WITH BRAIN 599 00:32:51,120 --> 00:32:52,520 FUNCTION. 600 00:32:52,520 --> 00:32:55,000 AND I THINK AND I WANT AND WE 601 00:32:55,000 --> 00:33:02,400 ARE WORKING TO -- TOWARDS IS TO 602 00:33:02,400 --> 00:33:07,840 CREATE THIS ECOSYSTEMS AND 603 00:33:07,840 --> 00:33:12,560 CREATE FRIENDLY TOOLS TO EXTRACT 604 00:33:12,560 --> 00:33:15,080 COMPUTABLE DATA SO PEOPLE CANNOT 605 00:33:15,080 --> 00:33:17,960 ONLY USE THIS REPOSITORY BUT 606 00:33:17,960 --> 00:33:23,240 THEY CAN CONTRIBUTE AND SHARE 607 00:33:23,240 --> 00:33:33,160 DATA AND YOU CAN EXPAND THE 608 00:33:33,160 --> 00:33:34,800 NUMBERS AVAILABLE FOR TESTING 609 00:33:34,800 --> 00:33:40,320 SETS OR FOR TRAINING SETS AND 610 00:33:40,320 --> 00:33:42,920 DOING THAT TYPE FOR EVERYBODY. 611 00:33:42,920 --> 00:33:45,200 THANK YOU FOR THE OPPORTUNITY TO 612 00:33:45,200 --> 00:33:46,880 TALK TO YOU TODAY AND SHOW YOU 613 00:33:46,880 --> 00:33:48,480 WHAT WE'VE BEEN DOING. 614 00:33:48,480 --> 00:33:49,480 >>THANK YOU SO MUCH. 615 00:33:49,480 --> 00:33:52,280 AND I WOULD LIKE TO ASK OTHER 616 00:33:52,280 --> 00:33:53,920 PANELISTS TO JOIN IN THE 617 00:33:53,920 --> 00:33:55,280 CONVERSATION AS WE HAVE A FEW 618 00:33:55,280 --> 00:33:58,760 QUESTIONS COMING IN FROM 619 00:33:58,760 --> 00:34:08,880 sli.do. 620 00:34:17,280 --> 00:34:20,200 >>WE RETAIN AND WE OFFER THIS 621 00:34:20,200 --> 00:34:23,720 INFORMATION -- WE OFFER ALL OF 622 00:34:23,720 --> 00:34:26,160 THE INFORMATION THAT WE WERE 623 00:34:26,160 --> 00:34:29,280 ALLOWED TO SO AGE FOR INSTANCE 624 00:34:29,280 --> 00:34:33,560 WE DON'T OFFER INFORMATION ABOUT 625 00:34:33,560 --> 00:34:38,560 PATIENTS OR 90 YEARS OLD OR 626 00:34:38,560 --> 00:34:41,880 BELOW TO YEARS OLD AND THAT IS 627 00:34:41,880 --> 00:34:43,000 THERE AVAILABLE FOR ANYONE TO 628 00:34:43,000 --> 00:34:43,440 USE. 629 00:34:43,440 --> 00:34:46,000 FROM THESE MODELS WE MADE 630 00:34:46,000 --> 00:34:48,000 INITIALLY SO, IT'S NOT -- THE 631 00:34:48,000 --> 00:34:49,720 INITIAL APPLICATIONS. 632 00:34:49,720 --> 00:34:52,080 THE ONES TOWARD STROKE 633 00:34:52,080 --> 00:34:53,960 SEGMENTATION AND THE STROKE 634 00:34:53,960 --> 00:34:56,080 CALCULATION OF DIFFERENT SCORES, 635 00:34:56,080 --> 00:35:00,280 NO, WE DIDN'T USE ANY OTHER 636 00:35:00,280 --> 00:35:01,360 INFORMATION OTHER THAN IMAGE. 637 00:35:01,360 --> 00:35:04,920 BUT THERE ARE OTHER APPLICATIONS 638 00:35:04,920 --> 00:35:06,240 WHERE THIS INFORMATION WOULD BE 639 00:35:06,240 --> 00:35:11,800 VERY VALUABLE. 640 00:35:11,800 --> 00:35:14,120 AND THAT IS WHY WE MADE IT 641 00:35:14,120 --> 00:35:16,040 AVAILABLE. 642 00:35:16,040 --> 00:35:16,680 >>THANK YOU. 643 00:35:16,680 --> 00:35:17,880 THAT IS WONDERFUL. 644 00:35:17,880 --> 00:35:22,280 WE HAVE A QUESTION THAT IS FOR 645 00:35:22,280 --> 00:35:23,280 BOTH PANELISTS. 646 00:35:23,280 --> 00:35:27,280 DO YOU ENVISION PROVIDING 647 00:35:27,280 --> 00:35:28,960 STANDARDIZING TEMPLATES THAT 648 00:35:28,960 --> 00:35:31,720 WOULD SUPPORT USERS TO ANALYZE 649 00:35:31,720 --> 00:35:33,720 AND UPLOAD AND SHARE ADDITIONAL 650 00:35:33,720 --> 00:35:34,280 DATA. 651 00:35:34,280 --> 00:35:37,120 THANK YOU FOR THIS. 652 00:35:37,120 --> 00:35:38,120 JAKOB. 653 00:35:38,120 --> 00:35:40,720 DO YOU MIND ANSWERING FIRST. 654 00:35:40,720 --> 00:35:42,040 >>REALLY GOOD QUESTION. 655 00:35:42,040 --> 00:35:45,160 GENERALLY WE HAVE A COUPLE BASIC 656 00:35:45,160 --> 00:35:47,240 TEMPLATES FOR THE CURRENT STATE 657 00:35:47,240 --> 00:35:49,600 OF HOW OUR TOOLS ARE OPERATING 658 00:35:49,600 --> 00:35:52,120 WHICH IS FAR DOWN THE BRAIN 659 00:35:52,120 --> 00:35:53,880 IMAGING PROCESS. 660 00:35:53,880 --> 00:35:55,880 AND ULTIMATELY WE WANT TO BUILD 661 00:35:55,880 --> 00:35:58,000 A MORE END TO END COMPONENT TO 662 00:35:58,000 --> 00:36:01,320 THE PIPELINE SO WITH THAT WE'LL 663 00:36:01,320 --> 00:36:04,200 ALLOW USERS TO INPUT SOMETHING 664 00:36:04,200 --> 00:36:06,200 THAT BASICALLY COMES OFF THE 665 00:36:06,200 --> 00:36:08,200 SCANNER AND THEN YOU'LL GET THE 666 00:36:08,200 --> 00:36:10,160 SAME OUTPUT. 667 00:36:10,160 --> 00:36:12,080 BRINGING THE INTERFACE CLOSER TO 668 00:36:12,080 --> 00:36:14,320 THE DATA WILL HELP FACILITATE 669 00:36:14,320 --> 00:36:14,960 THAT MORE. 670 00:36:14,960 --> 00:36:18,080 AND THEN GENERALLY IN BRAIN 671 00:36:18,080 --> 00:36:22,720 IMAGING THERE IS SOME STANDARDS 672 00:36:22,720 --> 00:36:32,920 THAT EXIST -- IN OUR CASE IN A 673 00:36:32,920 --> 00:36:35,720 DASHBOARD OR EXPLORING DIFFERENT 674 00:36:35,720 --> 00:36:39,720 ASPECTS OF BRAIN STRUCTURE OR 675 00:36:39,720 --> 00:36:43,120 LESION CAPACITIES IT'S AN OPEN 676 00:36:43,120 --> 00:36:44,720 QUESTION. 677 00:36:44,720 --> 00:36:47,680 >>YOUR THOUGHTS, ANDREIA? 678 00:36:47,680 --> 00:36:48,440 >>I AGREE. 679 00:36:48,440 --> 00:36:52,000 ONE OF THE SURPRISED WHEN I 680 00:36:52,000 --> 00:36:54,240 STARTED WORKING IS THAT METADATA 681 00:36:54,240 --> 00:36:57,960 WAS ACTUALLY MORE CHALLENGE THAN 682 00:36:57,960 --> 00:37:05,120 ORGANIZING THE METADATA WAS MORE 683 00:37:05,120 --> 00:37:06,760 CHALLENGING. 684 00:37:06,760 --> 00:37:11,360 IT SEEMS THERE IS MORE THE 685 00:37:11,360 --> 00:37:14,560 STRUCTURES IS MORE MATURE. 686 00:37:14,560 --> 00:37:16,680 SO YOU HAVE THESE PRINCIPLES ON 687 00:37:16,680 --> 00:37:19,760 HOW TO SHARE. 688 00:37:19,760 --> 00:37:21,080 PRINCIPLE FOR STRUCTURE LIKE 689 00:37:21,080 --> 00:37:21,600 THESE. 690 00:37:21,600 --> 00:37:26,160 AND I THINK METADATA HAS TO GO 691 00:37:26,160 --> 00:37:30,040 THROUGH THE SAME -- ALONG THE 692 00:37:30,040 --> 00:37:32,440 SAME LINE. 693 00:37:32,440 --> 00:37:38,560 I BELIEVE IN THE NEXT FEW YEARS 694 00:37:38,560 --> 00:37:43,280 IT-- IT'S EASIER TO ALLOW PEOPLE 695 00:37:43,280 --> 00:37:44,720 PARTICULARLY IF YOU'RE ASKING 696 00:37:44,720 --> 00:37:48,360 FOR INPUT TO MAKE CONSENSUS FOR 697 00:37:48,360 --> 00:37:50,440 STRUCTURE OF METADATA. 698 00:37:50,440 --> 00:37:51,080 >>THANK YOU. 699 00:37:51,080 --> 00:37:54,600 I THOUGHT THAT WAS REALLY 700 00:37:54,600 --> 00:37:56,520 INSIGHTFUL AND PROVIDING AND 701 00:37:56,520 --> 00:38:07,040 STANDARDIZING ME DEBT METADATA S 702 00:38:07,040 --> 00:38:07,480 CHALLENGING. 703 00:38:07,480 --> 00:38:10,800 WE HAVE SPECIFIC QUESTIONS. 704 00:38:10,800 --> 00:38:13,680 IN HIGH RISK PATIENTS WERE YOU 705 00:38:13,680 --> 00:38:17,480 ABLE TO GET AN MRI EVERY FIVE 706 00:38:17,480 --> 00:38:19,480 YEARS AND CAN WE PREDICT THE 707 00:38:19,480 --> 00:38:21,360 CHANCE OF STROKE BY APPLYING 708 00:38:21,360 --> 00:38:24,640 MACHINE LEARNING TO THESE DATA. 709 00:38:24,640 --> 00:38:28,160 OR OTHER DATA OF BRAIN MRI'S. 710 00:38:28,160 --> 00:38:30,240 I THINK I'M READING THIS 711 00:38:30,240 --> 00:38:30,960 CORRECTLY. 712 00:38:30,960 --> 00:38:32,000 WHAT DO YOU THINK. 713 00:38:32,000 --> 00:38:35,360 HIGH RISK PATIENTS EVERY FIVE 714 00:38:35,360 --> 00:38:36,320 YEARS. 715 00:38:36,320 --> 00:38:39,480 >>I HAVE THE NUMBERS. 716 00:38:39,480 --> 00:38:48,080 YOU CAN PREDICT -- THE 717 00:38:48,080 --> 00:38:54,120 BOTTLENECK IS NOT MATHEMATICAL. 718 00:38:54,120 --> 00:39:00,960 IT IS WELL OH COORDINA -- DECOOD 719 00:39:00,960 --> 00:39:05,560 DATA. *. 720 00:39:05,560 --> 00:39:09,600 BUT NOW REALLY ACCUMULATE WELL 721 00:39:09,600 --> 00:39:11,400 COORDINATED DATA IS THE BEST WAY 722 00:39:11,400 --> 00:39:14,200 TO MODEL WHAT YOU WANT TO MODEL 723 00:39:14,200 --> 00:39:16,200 AND IF YOU HAVE LARGE AMOUNTS OF 724 00:39:16,200 --> 00:39:20,760 DATA COLLECTED IN WHATEVER TIME 725 00:39:20,760 --> 00:39:23,320 YOU CAN BE EITHER CONSISTENT OR 726 00:39:23,320 --> 00:39:24,200 HARMONIZE IT. 727 00:39:24,200 --> 00:39:29,240 THE LIKELIHOOD OF PREDICTIONS 728 00:39:29,240 --> 00:39:34,840 EVEN IF IT IS A RELATIVELY 729 00:39:34,840 --> 00:39:36,960 OUTCOME IT'S LIKELY THAT YOU'LL 730 00:39:36,960 --> 00:39:39,960 GET SOMETHING THAT COMPARES WITH 731 00:39:39,960 --> 00:39:40,480 REALITY. 732 00:39:40,480 --> 00:39:41,480 BUT YEAH. 733 00:39:41,480 --> 00:39:45,120 IT DEPENDS ON CREATING ROBUST 734 00:39:45,120 --> 00:39:46,040 MODELS. 735 00:39:46,040 --> 00:39:52,480 AND I GUESS NUMBERS, YOU CANNOT 736 00:39:52,480 --> 00:39:53,640 BEAT REAL DATA YET. 737 00:39:53,640 --> 00:39:55,080 >>THANK YOU. 738 00:39:55,080 --> 00:39:58,200 LAST QUESTION THAT I SEE IN THE 739 00:39:58,200 --> 00:40:02,680 SLIDO IS VERY SPECIFIC. 740 00:40:02,680 --> 00:40:02,840 NO. 741 00:40:02,840 --> 00:40:04,440 WE HAVE MORE. 742 00:40:04,440 --> 00:40:07,440 HOW MANY ENCOUNTERS DO YOU HAVE 743 00:40:07,440 --> 00:40:09,080 PER PATIENT AND IS YOUR MODEL 744 00:40:09,080 --> 00:40:11,240 BASED ON TIME SERIES? 745 00:40:11,240 --> 00:40:11,720 >>NO. 746 00:40:11,720 --> 00:40:15,000 THIS IS CROSS SECTIONAL. 747 00:40:15,000 --> 00:40:16,760 ONE PATIENT ONE IMAGE. 748 00:40:16,760 --> 00:40:19,080 SO 3,000 DIFFERENT PATIENTS 749 00:40:19,080 --> 00:40:21,640 BECAUSE I'M WORKING WITH ACUTE 750 00:40:21,640 --> 00:40:23,280 STROKE. 751 00:40:23,280 --> 00:40:27,400 SO EVERYTHING HERE IS RELATED TO 752 00:40:27,400 --> 00:40:29,840 THE ACCURACY. 753 00:40:29,840 --> 00:40:33,840 AND THE THINGS THAT I SHOW THE 754 00:40:33,840 --> 00:40:35,680 LESION BASE STUDIES ARE THOSE 755 00:40:35,680 --> 00:40:44,400 THAT TRY TO EXCLUDE CHRONIC 756 00:40:44,400 --> 00:40:55,080 BRAIN PRPREMODULATION. 757 00:40:58,680 --> 00:41:01,080 WE ARE NOT YET AT THE SAME 758 00:41:01,080 --> 00:41:02,880 APPOINTMENT AS WE ARE FOR ACUTE 759 00:41:02,880 --> 00:41:04,240 STROKE. 760 00:41:04,240 --> 00:41:06,520 >>THANK YOU. 761 00:41:06,520 --> 00:41:08,160 I'D LIKE TO ASK THIS QUESTION OF 762 00:41:08,160 --> 00:41:10,320 BOTH OF YOU HERE IN SLIDO 763 00:41:10,320 --> 00:41:12,120 BECAUSE IT'S SOMETHING THAT OUR 764 00:41:12,120 --> 00:41:13,320 OFFICE IS VERY INTERESTED IN. 765 00:41:13,320 --> 00:41:15,720 THE MEASURE OF AI READY DATA. 766 00:41:15,720 --> 00:41:17,880 WOULD YOU HAVE SOME IDEAS ABOUT 767 00:41:17,880 --> 00:41:20,960 STANDARD METRICS TO MEASURE WHAT 768 00:41:20,960 --> 00:41:24,280 WE WOULD CONSIDER AI READY DATA 769 00:41:24,280 --> 00:41:25,520 JAKOB, DO YOU HAVE THOUGHTS ON 770 00:41:25,520 --> 00:41:26,320 THIS? 771 00:41:26,320 --> 00:41:28,320 >>YEAH. 772 00:41:28,320 --> 00:41:33,080 I THINK YOU HAVE A MULTI-LEVEL 773 00:41:33,080 --> 00:41:38,680 HARMONIZATION PROBLEM THAT 774 00:41:38,680 --> 00:41:40,720 BECOMES COMPLICATED. 775 00:41:40,720 --> 00:41:43,400 AND I THINK THE FURTHER AWAY YOU 776 00:41:43,400 --> 00:41:46,760 GET FROM THE ACTUAL RAW IMAGE 777 00:41:46,760 --> 00:41:49,960 THE MORE CONVOLUTED THAT CAN 778 00:41:49,960 --> 00:41:50,640 BECOME. 779 00:41:50,640 --> 00:41:53,680 IN OUR EFFORT WE BASICALLY USED 780 00:41:53,680 --> 00:41:56,560 STATISTICS TO HELP COMBAT THAT 781 00:41:56,560 --> 00:41:57,080 HARMONIZATION PROBLEM. 782 00:41:57,080 --> 00:42:01,640 BUT IT REALLY OUGHT TO BE AT THE 783 00:42:01,640 --> 00:42:04,160 ACQUISITION WHERE WE'RE SPENDING 784 00:42:04,160 --> 00:42:05,840 MORE RESOURCES ON THE 785 00:42:05,840 --> 00:42:07,040 STANDARDIZATION FOR THE IMAGE 786 00:42:07,040 --> 00:42:09,040 THAT IS RECONSTRUCTED AND THEN 787 00:42:09,040 --> 00:42:12,080 WE CAN RUN OUR MODELS ON OR OUR 788 00:42:12,080 --> 00:42:12,720 PROCESSING ON. 789 00:42:12,720 --> 00:42:14,560 AND I THINK THAT IS BEING DONE. 790 00:42:14,560 --> 00:42:16,800 AND IT IS DONE IN CLINICAL 791 00:42:16,800 --> 00:42:18,920 TRIALS AND OTHER MULTI-SITE 792 00:42:18,920 --> 00:42:19,640 DESIGNS ETC. 793 00:42:19,640 --> 00:42:22,120 SO I THINK THERE IS HOPE IN 794 00:42:22,120 --> 00:42:24,120 TERMS OF STANDARD METRICS FOR 795 00:42:24,120 --> 00:42:24,320 THAT. 796 00:42:24,320 --> 00:42:27,720 I THINK THE BEST STILL THE OLD 797 00:42:27,720 --> 00:42:32,120 SCHOOL TRAVELING HEAD STUDY 798 00:42:32,120 --> 00:42:36,440 INDIVIDUALS THAT ARE THAT HAVE 799 00:42:36,440 --> 00:42:39,960 REPRESENTATION ACROSS THE 800 00:42:39,960 --> 00:42:42,280 VARIABILITY ARE STILL HUGELY 801 00:42:42,280 --> 00:42:43,280 GOLD STANDARD WHERE YOU CAN 802 00:42:43,280 --> 00:42:45,520 ACTUALLY MEASURE THE IMPACT OF 803 00:42:45,520 --> 00:42:49,160 SOME OF THESE NOISE FACTORS AND 804 00:42:49,160 --> 00:42:50,640 THRESHOLD WISE I DON'T EVER A 805 00:42:50,640 --> 00:42:52,760 GOOD NUMBER BUT MINIMIZING THAT 806 00:42:52,760 --> 00:42:54,200 VARIANCE WILL INCREASE THE 807 00:42:54,200 --> 00:42:57,640 SIGNAL FOR THE RESULTING OUTPUT. 808 00:42:57,640 --> 00:42:58,400 >>THANK YOU. 809 00:42:58,400 --> 00:43:01,480 THAT IS REALLY HELPFUL. 810 00:43:01,480 --> 00:43:02,520 ANDREIA, DO YOU EVER SOME 811 00:43:02,520 --> 00:43:04,600 THOUGHTS ON MEASURING THE AI 812 00:43:04,600 --> 00:43:05,960 DATA ON THE WORK THAT YOU'RE 813 00:43:05,960 --> 00:43:06,760 DOING? 814 00:43:06,760 --> 00:43:07,720 >>YEAH. 815 00:43:07,720 --> 00:43:10,400 WORKING WITH STROKE IS 816 00:43:10,400 --> 00:43:14,400 CHALLENGING IN MANY SENSE BUT 817 00:43:14,400 --> 00:43:17,760 THERE IS ONE POINT THAT MAKES IT 818 00:43:17,760 --> 00:43:21,880 MUCH EASIER BECAUSE THE WHAT 819 00:43:21,880 --> 00:43:25,760 WE'RE LOOKING AT THE DISEASE 820 00:43:25,760 --> 00:43:29,040 EFFECT IS SO HUGE. 821 00:43:29,040 --> 00:43:31,560 ANYONE CAN SEE THE LESION THERE 822 00:43:31,560 --> 00:43:34,240 -- THAT EVEN WITH A LOT OF 823 00:43:34,240 --> 00:43:36,720 POPULATION OF TECHNICAL 824 00:43:36,720 --> 00:43:40,240 VARIATION THE EFFECT SIZE IS WAY 825 00:43:40,240 --> 00:43:48,880 BIGGER THAN DESIRED. 826 00:43:48,880 --> 00:43:50,760 HAVING SAYS THAT IT'S VERY 827 00:43:50,760 --> 00:43:56,120 INTERESTING BECAUSE WE DO ALL OF 828 00:43:56,120 --> 00:43:57,080 THESE ARTIFICIAL INTELLIGENCE 829 00:43:57,080 --> 00:43:59,280 CONTROLS AND MODELS AND ETC. BUT 830 00:43:59,280 --> 00:44:01,600 AT THE END WHEN WE'RE GOING TO 831 00:44:01,600 --> 00:44:04,720 GO THERE AND CHECK HOW WE AGREE 832 00:44:04,720 --> 00:44:08,360 WITH THE HUMANS OR HOW WE AGREE 833 00:44:08,360 --> 00:44:10,000 WITHSTANDS WE GO TO THE 834 00:44:10,000 --> 00:44:11,840 CLASSICAL STATISTICS IN GENERAL. 835 00:44:11,840 --> 00:44:15,840 AGAIN JUST A QUESTION OF I 836 00:44:15,840 --> 00:44:18,640 DON'T, I WOULD NOT COMPARE. 837 00:44:18,640 --> 00:44:23,480 THAT IS NOT MY FIELD. 838 00:44:23,480 --> 00:44:27,120 BUT I BELIEVE PEOPLE WILL FIGURE 839 00:44:27,120 --> 00:44:31,440 OUT IN THE NEXT FEW YEARS HOW AI 840 00:44:31,440 --> 00:44:37,040 CAN GET YOU -- AND MAYBE 841 00:44:37,040 --> 00:44:39,800 SELF-CONTROL THE MODELS AND THE 842 00:44:39,800 --> 00:44:40,280 HOURS. 843 00:44:40,280 --> 00:44:40,960 >>THANK YOU. 844 00:44:40,960 --> 00:44:45,000 WE HAVE A GOOD QUESTION. 845 00:44:45,000 --> 00:44:51,680 LARGE LANGUAGE MODELS AND CHAT 846 00:44:51,680 --> 00:44:56,240 GPT. 847 00:44:56,240 --> 00:44:59,520 WHAT DO YOU THINK IS THE FUTURE 848 00:44:59,520 --> 00:45:02,520 FOR THESE LARGE LANGUAGE MODELS. 849 00:45:02,520 --> 00:45:04,840 A VERY PARTICULAR QUESTION FOR 850 00:45:04,840 --> 00:45:09,000 EXAMPLE HIGHLIGHTING POSSIBLE 851 00:45:09,000 --> 00:45:11,160 PATHOLOGICAL REGIONS. 852 00:45:11,160 --> 00:45:16,800 I WOULD LOVE TO HAVE YOUR 853 00:45:16,800 --> 00:45:19,040 THOUGHTS IN IDENTIFYING 854 00:45:19,040 --> 00:45:23,040 PARTICULAR REGIONS. 855 00:45:23,040 --> 00:45:25,440 ANDREIA, IF YOU WOULD LIKE TO GO 856 00:45:25,440 --> 00:45:27,480 FIRST 857 00:45:27,480 --> 00:45:32,000 >>I THINK -- FROM THE CLINICAL 858 00:45:32,000 --> 00:45:35,720 POINT OF VIEW CONDITIONS THAT 859 00:45:35,720 --> 00:45:44,840 NEED QUANEED QUALIFICATION. 860 00:45:44,840 --> 00:45:45,520 QUANTIFICATION. 861 00:45:45,520 --> 00:45:48,920 *. 862 00:45:48,920 --> 00:45:52,920 AND THAT IS ANOTHER THING THAT 863 00:45:52,920 --> 00:45:58,720 WE WILL BE THE NICHE FOR ALL OF 864 00:45:58,720 --> 00:45:59,480 THESE MODELS. 865 00:45:59,480 --> 00:46:00,960 WE ARE NOT THERE AND WE DON'T 866 00:46:00,960 --> 00:46:02,080 WANT TO GO THERE. 867 00:46:02,080 --> 00:46:05,360 I THINK IT'S ALL ABOUT OFFERING 868 00:46:05,360 --> 00:46:08,880 HELP, HELPING ON SAVING TIME OR 869 00:46:08,880 --> 00:46:14,360 HELPING FLAG SOMETHING THAT IS 870 00:46:14,360 --> 00:46:17,920 -- A KNOWN EXPERIENCED PERSON, 871 00:46:17,920 --> 00:46:21,600 WE TALK ABOUT DEMOCRATIZING BOTH 872 00:46:21,600 --> 00:46:27,600 HEALTH CARE AND RESEARCH. 873 00:46:27,600 --> 00:46:33,640 AND ALSO ABOUT GUIDING THE 874 00:46:33,640 --> 00:46:37,640 EFFORT THE HUMAN EFFORT TO 875 00:46:37,640 --> 00:46:41,680 SOMETHING THAT MAY BE ABOVE -- 876 00:46:41,680 --> 00:46:44,320 LIKE TRACING THE LARGER PLANES 877 00:46:44,320 --> 00:46:51,040 FOR DATA USAGE AND DEMOCRATIZING 878 00:46:51,040 --> 00:46:52,440 IN BETWEEN EXPERTISE. 879 00:46:52,440 --> 00:46:54,200 IT'S VERY HARD FOR PEOPLE 880 00:46:54,200 --> 00:46:56,320 WORKING IN IMAGE BECAUSE IT HAS 881 00:46:56,320 --> 00:47:02,240 TO BE AN IMAGE EXPERT TO EXTRACT 882 00:47:02,240 --> 00:47:06,120 BRAIN VOLUMES AS JAKOB DID BUT 883 00:47:06,120 --> 00:47:08,120 CLINICIANS WANT TO USE THESE AND 884 00:47:08,120 --> 00:47:10,760 THEY DON'T WANT TO DO FIVE YEARS 885 00:47:10,760 --> 00:47:11,400 TRAINING. 886 00:47:11,400 --> 00:47:14,400 SO I THINK THAT IS THE NICHE OF 887 00:47:14,400 --> 00:47:17,320 AI TO BE ABLE TO OFFER DATA TO 888 00:47:17,320 --> 00:47:20,720 PEOPLE WITH DIFFERENT EXPERTISE 889 00:47:20,720 --> 00:47:27,200 CAN COMMUNICATE AND DEMOCRATIZE 890 00:47:27,200 --> 00:47:29,120 THE FRUITS. 891 00:47:29,120 --> 00:47:32,000 >>JAKOB ... 892 00:47:32,000 --> 00:47:33,000 >>ABSOLUTELY. 893 00:47:33,000 --> 00:47:34,640 ANDREIA TOUCHED ON THE POINTS. 894 00:47:34,640 --> 00:47:42,480 THE SIMPLEST THINGS THAT IT WILL 895 00:47:42,480 --> 00:47:48,000 EXPEDITE HYPOTHESIS GENERATION. 896 00:47:48,000 --> 00:47:50,760 TO USE TOOLS. 897 00:47:50,760 --> 00:47:53,080 SO ABSOLUTELY. 898 00:47:53,080 --> 00:47:55,840 EXPEDITE THAT AND IT WILL 899 00:47:55,840 --> 00:47:56,760 EXPEDITE THE FAIL RATE. 900 00:47:56,760 --> 00:47:59,560 MOST OF WHAT WE DO IS WE BANG 901 00:47:59,560 --> 00:48:03,160 OUR HEADS A AGAINST THE WALL TO 902 00:48:03,160 --> 00:48:04,120 SOLVE THE PROBLEM. 903 00:48:04,120 --> 00:48:06,600 BUT IT WILL BE A QUICKER FAIL 904 00:48:06,600 --> 00:48:07,120 RATE. 905 00:48:07,120 --> 00:48:08,880 AND THAT IS EXCITING BECAUSE 906 00:48:08,880 --> 00:48:12,240 THAT CHANGES THE LANDSCAPE FROM 907 00:48:12,240 --> 00:48:13,680 A SCIENTIFIC TRAINING 908 00:48:13,680 --> 00:48:15,480 PERSPECTIVE OF HOW TO INTERACT 909 00:48:15,480 --> 00:48:17,920 WITH THESE TOOLS AS A MENTOR 910 00:48:17,920 --> 00:48:19,400 VERSUS A STUDENT ETC. 911 00:48:19,400 --> 00:48:21,520 AND I FIND THOSE ISSUES 912 00:48:21,520 --> 00:48:23,720 ALONGSIDE THE ETHICAL ISSUES 913 00:48:23,720 --> 00:48:25,960 REALLY FASCINATING BUT FOR OUR 914 00:48:25,960 --> 00:48:27,400 TOOL ULTIMATELY IT WILL BE 915 00:48:27,400 --> 00:48:30,160 REALLY AMAZING TO BE ABLE TO ASK 916 00:48:30,160 --> 00:48:31,960 QUESTIONS ABOUT WHERE TO LOOK IN 917 00:48:31,960 --> 00:48:32,720 THE BRAIN. 918 00:48:32,720 --> 00:48:36,000 FOR A GIVEN CONDITION OR PATIENT 919 00:48:36,000 --> 00:48:38,000 WITH THE ELECTRONIC HEALTH 920 00:48:38,000 --> 00:48:38,440 RECORDS. 921 00:48:38,440 --> 00:48:40,800 IT WILL MAKE THESE THINGS MORE 922 00:48:40,800 --> 00:48:42,520 EFFICIENT AND ROBUST. 923 00:48:42,520 --> 00:48:44,560 THEY WILL STILL SUFFER FROM BIAS 924 00:48:44,560 --> 00:48:46,680 IN CERTAIN CASES BUT ULTIMATELY 925 00:48:46,680 --> 00:48:48,240 IT WILL BE VERY GOOD AIDS FOR 926 00:48:48,240 --> 00:48:50,160 OUR WORK. 927 00:48:50,160 --> 00:48:50,600 >>WONDERFUL. 928 00:48:50,600 --> 00:48:51,920 I HAVE ANOTHER QUESTION IN THE 929 00:48:51,920 --> 00:48:53,560 SLIDO. 930 00:48:53,560 --> 00:48:55,800 I'M THINKING ABOUT THIS PRIZE 931 00:48:55,800 --> 00:48:57,120 CHALLENGE AND YOUR 932 00:48:57,120 --> 00:48:58,200 PARTICIPATION. 933 00:48:58,200 --> 00:49:00,760 WHERE DO YOU SEE SIM LASH 934 00:49:00,760 --> 00:49:03,200 INCENTIVES FOR PROMOTING DATA 935 00:49:03,200 --> 00:49:06,320 REUSE AND YOUR OPPORTUNITY 936 00:49:06,320 --> 00:49:07,320 PONTIFICATED ABOUT THIS 937 00:49:07,320 --> 00:49:09,760 CHALLENGE. 938 00:49:09,760 --> 00:49:13,600 I WOULD LOVE TO HEAR YOUR INPUT 939 00:49:13,600 --> 00:49:16,720 ON THIS CHALLENGE. 940 00:49:16,720 --> 00:49:18,400 >>JAKOB, DO YOU WANT TO TAKE 941 00:49:18,400 --> 00:49:19,720 THAT ONE FIRST? 942 00:49:19,720 --> 00:49:21,160 >>I'M THINKING ON THE SPOT AS 943 00:49:21,160 --> 00:49:22,200 WELL ABOUT OTHER OPPORTUNITIES 944 00:49:22,200 --> 00:49:24,680 THAT I'VE SEEN. 945 00:49:24,680 --> 00:49:26,520 AND I MAY NOT HAVE A DIRECT 946 00:49:26,520 --> 00:49:28,120 ANSWER TO THAT RIGHT NOW. 947 00:49:28,120 --> 00:49:34,200 THE IRONY OF ME SITTING TODAY A 948 00:49:34,200 --> 00:49:36,200 CO-AUTHOR PINGED US THIS 949 00:49:36,200 --> 00:49:38,200 ANNOUNCEMENT. 950 00:49:38,200 --> 00:49:46,640 ULTIMATE LEADIT -- THE PARTICULR 951 00:49:46,640 --> 00:49:48,760 THESE PURPOSES THAT ARE 952 00:49:48,760 --> 00:49:49,760 NONINSTITUTIONAL. 953 00:49:49,760 --> 00:49:51,240 INSTITUTION WOULD BE GREAT. 954 00:49:51,240 --> 00:49:53,920 BIAS FOR THE BIG MONEY 955 00:49:53,920 --> 00:49:55,360 INSTITUTIONS AND DEDICATED 956 00:49:55,360 --> 00:49:59,120 ASSETS FOR THAT LOCALLY BUT 957 00:49:59,120 --> 00:50:01,120 HAVING THESE GLOBAL BIG WELL 958 00:50:01,120 --> 00:50:04,120 ESTABLISHED FUNDERS BE THE ONE 959 00:50:04,120 --> 00:50:06,120 THAT'S ARE FACILITATING THESE 960 00:50:06,120 --> 00:50:11,280 AWARDS IS ULTIMATELY GOING TO 961 00:50:11,280 --> 00:50:12,600 GET PEOPLE'S ATTENTION. 962 00:50:12,600 --> 00:50:14,720 >>THANK YOU. 963 00:50:14,720 --> 00:50:15,960 ANDREIA, WHAT ARE YOUR THOUGHTS 964 00:50:15,960 --> 00:50:18,200 ON THIS CHALLENGE AND OTHER 965 00:50:18,200 --> 00:50:22,240 INCENTIVES AND HOW CAN WE 966 00:50:22,240 --> 00:50:26,560 PROMOTE DATA REUSE. 967 00:50:26,560 --> 00:50:28,000 >>YEAH. 968 00:50:28,000 --> 00:50:37,000 IT'S ONE -- IT HAS TO BE MORE -- 969 00:50:37,000 --> 00:50:39,320 RECOGNITION. 970 00:50:39,320 --> 00:50:43,720 THERE IS NO OTHER WAY TO GO IN 971 00:50:43,720 --> 00:50:45,920 DATA SCIENCE IF NOT THROUGH 972 00:50:45,920 --> 00:50:49,440 COLLABORATION AND SHARING DATA. 973 00:50:49,440 --> 00:50:53,320 IT SEEMS VERY TIME-CONSUMING, IT 974 00:50:53,320 --> 00:50:59,280 MAY CONSUME 80%-90% OF YOUR 975 00:50:59,280 --> 00:51:01,360 WHOLE RESEARCH TIME AND IT'S 976 00:51:01,360 --> 00:51:05,040 INEVITABLE AND IT LEADS YOU TO 977 00:51:05,040 --> 00:51:07,520 NICE DISCOVERIES. 978 00:51:07,520 --> 00:51:10,840 RELIABLE DISCOVERIES. 979 00:51:10,840 --> 00:51:16,000 AND I THINK GRANTS, CHALLENGE. 980 00:51:16,000 --> 00:51:20,280 SCIENTISTS LIKE CHALLENGES. 981 00:51:20,280 --> 00:51:24,600 ALSO OFFERING MAYBE COMMON 982 00:51:24,600 --> 00:51:27,000 RESOURCES LIKE REPOSITORIES. 983 00:51:27,000 --> 00:51:28,280 THIS IS VERY IMPORTANT. 984 00:51:28,280 --> 00:51:30,640 YOU MAY ACCUMULATE NICE AMOUNTS 985 00:51:30,640 --> 00:51:33,520 OF DATA AND THAT IS ONE 986 00:51:33,520 --> 00:51:36,000 CHALLENGE WE HAVE WHICH 987 00:51:36,000 --> 00:51:38,720 REPOSITORY WOULD WE USE. 988 00:51:38,720 --> 00:51:41,080 THAT WOULD AFFECT LARGE AMOUNTS 989 00:51:41,080 --> 00:51:46,200 OF DATA. 990 00:51:46,200 --> 00:51:49,880 MAYBE FUNDING AND REPOSITORIES 991 00:51:49,880 --> 00:51:52,120 AND WAYS TO SHARE DATA WOULD BE 992 00:51:52,120 --> 00:51:54,600 A NICE DIRECTION. 993 00:51:54,600 --> 00:51:55,160 >>WONDERFUL. 994 00:51:55,160 --> 00:51:57,560 BEFORE I GET TO THE LAST 995 00:51:57,560 --> 00:52:00,440 QUESTION I WANT TO ASK A REQUEST 996 00:52:00,440 --> 00:52:01,640 FROM ME TO YOU. 997 00:52:01,640 --> 00:52:03,360 HOW DO YOU SEE THE RESEARCH 998 00:52:03,360 --> 00:52:04,680 COMMUNITY ENGAGING WITH YOUR 999 00:52:04,680 --> 00:52:06,560 WORK THAT YOU PRESENTED TODAY 1000 00:52:06,560 --> 00:52:08,880 AND HOW DO YOU SEE THEM REUSING 1001 00:52:08,880 --> 00:52:13,720 YOUR DATA TO CREATE NEW RESEARCH 1002 00:52:13,720 --> 00:52:16,520 FINDINGS AND HYPOTHESIS? 1003 00:52:16,520 --> 00:52:17,880 ANDREIA. 1004 00:52:17,880 --> 00:52:18,400 >>YEAH. 1005 00:52:18,400 --> 00:52:24,280 I THINK FOR INSTANCE WITH OUR -- 1006 00:52:24,280 --> 00:52:28,200 WE SHARE THESE TOOLS PUBLICLY AS 1007 00:52:28,200 --> 00:52:31,720 YOU SAW AND THEN EVERY YEAR 1008 00:52:31,720 --> 00:52:33,760 RECEIVE DOZENS OF IMAGES FROM 1009 00:52:33,760 --> 00:52:35,200 PEOPLE AROUND THE WORLD THAT 1010 00:52:35,200 --> 00:52:38,040 WANT TO USE THE RESOURCES OR MAY 1011 00:52:38,040 --> 00:52:40,160 BE ASKING QUESTIONS. 1012 00:52:40,160 --> 00:52:44,560 AND FOR -- I THINK IT'S 1013 00:52:44,560 --> 00:52:47,120 DIFFICULT FOR SOME MODELS BUT 1014 00:52:47,120 --> 00:52:49,120 FOR DISEASE LIKE STROKE OR 1015 00:52:49,120 --> 00:52:53,640 HEALTHY BRAIN -- EVERYONE HAS 1016 00:52:53,640 --> 00:52:58,600 HIS OR HER LITTLE DATASET THAT 1017 00:52:58,600 --> 00:53:01,960 THEY WOULD BE VERY GLAD TO SHARE 1018 00:53:01,960 --> 00:53:05,360 IF THEY CAN COUNT WITH THE 1019 00:53:05,360 --> 00:53:12,600 FRUITS OF SHARING. 1020 00:53:12,600 --> 00:53:13,280 SO I THINK ONE BIG POINT IS THAT 1021 00:53:13,280 --> 00:53:16,280 IF YOU CAN HAVE THIS ORGANIZED 1022 00:53:16,280 --> 00:53:20,560 REPOSITORY THAT ALLOW NOT JUST 1023 00:53:20,560 --> 00:53:22,720 DOWNLOADING BUT INPUTS AND ALSO 1024 00:53:22,720 --> 00:53:25,360 WORK FOR LIFE BECAUSE THEY HAVE 1025 00:53:25,360 --> 00:53:28,680 QUALITY CONTROL THAT IS THERE 1026 00:53:28,680 --> 00:53:30,760 FOR -- LIFE. 1027 00:53:30,760 --> 00:53:34,080 BUT PEOPLE WOULD BE MORE THAN 1028 00:53:34,080 --> 00:53:36,400 GLAD TO DEVELOP THIS NEW MODEL 1029 00:53:36,400 --> 00:53:37,440 OF RESEARCH. 1030 00:53:37,440 --> 00:53:39,320 THIS COLLABORATIVE MODEL OF 1031 00:53:39,320 --> 00:53:42,080 RESEARCH THAT ACCELERATES THE 1032 00:53:42,080 --> 00:53:46,480 RESEARCH FOR EVERYONE INVOLVED. 1033 00:53:46,480 --> 00:53:49,080 >>THANK YOU SO MUCH. 1034 00:53:49,080 --> 00:53:50,080 JAKOB, WHAT DO YOU THINK. 1035 00:53:50,080 --> 00:53:52,080 HOW CAN RESEARCHERS ENGAGE WITH 1036 00:53:52,080 --> 00:53:55,280 YOU AND YOUR WORK AND PROMOTE 1037 00:53:55,280 --> 00:53:56,920 DATA REUSE IN THEIR OWN 1038 00:53:56,920 --> 00:53:57,360 RESEARCH. 1039 00:53:57,360 --> 00:53:59,560 >>I THINK THE BIGGEST THING IS 1040 00:53:59,560 --> 00:54:01,840 TO GIVE FEEDBACK. 1041 00:54:01,840 --> 00:54:05,280 FROM THE RESOURCE THAT WE BUILT 1042 00:54:05,280 --> 00:54:06,120 GIVE FEED BAD. 1043 00:54:06,120 --> 00:54:08,000 WE'RE HERE AND DOING OUR 1044 00:54:08,000 --> 00:54:08,240 SCIENCE. 1045 00:54:08,240 --> 00:54:10,240 WE WANT TO MAKE THIS A 1046 00:54:10,240 --> 00:54:11,720 SUSTAINABLE RESOURCE WITH THE 1047 00:54:11,720 --> 00:54:13,160 RESOURCE THAT'S WE HAVE 1048 00:54:13,160 --> 00:54:14,640 INTERNALLY. 1049 00:54:14,640 --> 00:54:17,000 PEOPLE HAVE E-MAILED US TO HELP 1050 00:54:17,000 --> 00:54:17,520 OUT. 1051 00:54:17,520 --> 00:54:19,480 PEOPLE WANT TO SHARE DATA. THAT 1052 00:54:19,480 --> 00:54:27,240 IS THE BIGGEST LEARNING PROCESS. 1053 00:54:27,240 --> 00:54:32,920 I CULLED HUNDREDS OF E-MAIL. 1054 00:54:32,920 --> 00:54:35,600 AND THEY ALL WANTED TO SHARE 1055 00:54:35,600 --> 00:54:36,560 DATA. 1056 00:54:36,560 --> 00:54:43,040 THE POINT BEING IS INTERACT-AND 1057 00:54:43,040 --> 00:54:45,280 COMMUNICATE WITH US AND WE CAN 1058 00:54:45,280 --> 00:54:47,040 HELP FACILITATE OTHER RESOURCES. 1059 00:54:47,040 --> 00:54:50,600 THIS IS THE FIRST STEP ALWAYS IN 1060 00:54:50,600 --> 00:54:53,880 A LONGER HOPEFULLY MORE 1061 00:54:53,880 --> 00:54:55,520 SUSTAINABLE INFRASTRUCTURE. 1062 00:54:55,520 --> 00:54:58,000 AND THEN I GUESS THE OTHER THING 1063 00:54:58,000 --> 00:55:00,640 IS WHAT WE DID OR WE TRIED TO DO 1064 00:55:00,640 --> 00:55:02,440 IS WHEN WE COULD NOT SHARE THE 1065 00:55:02,440 --> 00:55:05,120 DATA WE TRIED TO PUT THE LINKS 1066 00:55:05,120 --> 00:55:07,400 TO THE RESOURCES. 1067 00:55:07,400 --> 00:55:10,160 SEARCHING ON-LINE TAKES FOREVER 1068 00:55:10,160 --> 00:55:12,480 AND SOMETIMES THE ACCESS 1069 00:55:12,480 --> 00:55:14,800 PROTOCOLS EVEN IF IT'S OPEN DATA 1070 00:55:14,800 --> 00:55:17,920 IT'S A HUGE BURDEN SO WE CAN 1071 00:55:17,920 --> 00:55:19,240 HELP FACILITATE ANSWERING 1072 00:55:19,240 --> 00:55:20,960 QUESTIONS ABOUT HOW WE GOT 1073 00:55:20,960 --> 00:55:23,320 ACCESS TO CERTAIN DATASETS. 1074 00:55:23,320 --> 00:55:25,440 OR HOW TO USE THE DATA THAT IS 1075 00:55:25,440 --> 00:55:25,840 AVAILABLE. 1076 00:55:25,840 --> 00:55:28,320 SO BASICALLY BACK TO THE FIRST 1077 00:55:28,320 --> 00:55:29,640 SIMPLE POINT IS JUST 1078 00:55:29,640 --> 00:55:30,320 COMMUNICATE. 1079 00:55:30,320 --> 00:55:31,880 THAT IS THE BEST THING IS MAKE 1080 00:55:31,880 --> 00:55:34,680 US AWARE OF SOMETHING THAT'S AN 1081 00:55:34,680 --> 00:55:36,880 ISSUE OR WHAT LIKE OR DON'T LIKE 1082 00:55:36,880 --> 00:55:39,320 AND WHAT YOU WANT TO SEE 1083 00:55:39,320 --> 00:55:39,760 IMPROVED. 1084 00:55:39,760 --> 00:55:41,880 THAT IS THE BEST WAY FOR US TO 1085 00:55:41,880 --> 00:55:43,960 BE ABLE TO LEARN. 1086 00:55:43,960 --> 00:55:44,760 >>THAT IS WONDERFUL. 1087 00:55:44,760 --> 00:55:47,080 I WANT TO COMMEND BOTH OF YOU ON 1088 00:55:47,080 --> 00:55:48,800 THE WORK THAT YOU'VE DONE. 1089 00:55:48,800 --> 00:55:51,640 THESE ARE INCREDIBLE TALKS. 1090 00:55:51,640 --> 00:55:54,720 AND ALSO INCREDIBLE RESOURCES TO 1091 00:55:54,720 --> 00:55:57,040 USE TO UNDERSTAND IMAGING. 1092 00:55:57,040 --> 00:55:58,920 AND BRAIN FUNCTION. 1093 00:55:58,920 --> 00:56:01,880 THE LAST QUESTION IS A QUESTION 1094 00:56:01,880 --> 00:56:03,960 FOR NIH AND FASEB. 1095 00:56:03,960 --> 00:56:06,560 IS WHAT IS THE NEXT CHALLENGE? 1096 00:56:06,560 --> 00:56:08,800 I'M HAPPY TO TELL YOU THAT THIS 1097 00:56:08,800 --> 00:56:11,240 MORNING WE'VE APPROVAL FROM OUR 1098 00:56:11,240 --> 00:56:12,960 LEGAL SIDE AT NIH TO CONTINUE 1099 00:56:12,960 --> 00:56:14,480 WITH THIS CHALLENGE SO WE'RE 1100 00:56:14,480 --> 00:56:17,240 GOING THROUGH THE FINAL PROCESS 1101 00:56:17,240 --> 00:56:23,440 OF GETTING THIS PARTNERSHIP 1102 00:56:23,440 --> 00:56:24,120 CONTINUATION. 1103 00:56:24,120 --> 00:56:26,880 WE'VE APPROVAL FROM OUR LEGAL 1104 00:56:26,880 --> 00:56:30,840 TEAM SO YEAH! 1105 00:56:30,840 --> 00:56:35,800 I WANT TO INTRO DUE MY COLLEAGUE 1106 00:56:35,800 --> 00:56:38,040 WHO IS LEADING US AT NIH ON THE 1107 00:56:38,040 --> 00:56:39,800 PARTNERSHIP WITH FASEB AND DATA 1108 00:56:39,800 --> 00:56:40,440 WORKS. 1109 00:56:40,440 --> 00:56:44,120 IF YOU'RE THERE COME ON AND 1110 00:56:44,120 --> 00:56:46,640 PLEASE SAY A FEW WORDS ABOUT THE 1111 00:56:46,640 --> 00:56:47,880 CHALLENGE AND YOUR VISION. 1112 00:56:47,880 --> 00:56:52,240 I SHOULD HAVE INTRODUCED YOU AT 1113 00:56:52,240 --> 00:56:53,080 THE BEGINNING. 1114 00:56:53,080 --> 00:56:55,760 >>THANK YOU FOR THE OPPORTUNITY 1115 00:56:55,760 --> 00:56:59,320 AND THIS IS SUPER EXCITING TO 1116 00:56:59,320 --> 00:57:08,520 HEAR BOTH JAKOB AND ANDREIA TO 1117 00:57:08,520 --> 00:57:09,480 SHARE. 1118 00:57:09,480 --> 00:57:11,640 TO GIVE OPPORTUNITIES FOR MORE 1119 00:57:11,640 --> 00:57:13,720 PEOPLE IN THE COMMUNITY. 1120 00:57:13,720 --> 00:57:16,360 THE MOST IMPORTANT LESSON IS TO 1121 00:57:16,360 --> 00:57:19,120 GO FROM BIG LARGE DATA PROJECTS 1122 00:57:19,120 --> 00:57:21,920 ALL THE WAY THROUGH TO OUR 1123 00:57:21,920 --> 00:57:25,520 INDIVIDUAL RESEARCHERS AND RO1 1124 00:57:25,520 --> 00:57:28,760 GRANTEES AND HOW THEY CAN BE 1125 00:57:28,760 --> 00:57:30,040 ENABLED. 1126 00:57:30,040 --> 00:57:32,240 HOW CAN WE PROVIDE TOOLS AND 1127 00:57:32,240 --> 00:57:34,800 RESOURCE THAT'S ARE THERE THAT 1128 00:57:34,800 --> 00:57:37,120 ENABLE EVERY PERSON IN THE 1129 00:57:37,120 --> 00:57:38,480 LARGER RESEARCH LANDSCAPE TO 1130 00:57:38,480 --> 00:57:39,440 ENGAGE WITH THIS. 1131 00:57:39,440 --> 00:57:42,000 THAT IS THE FOCUS NEXT YEAR AND 1132 00:57:42,000 --> 00:57:43,560 WE'RE HOPING THAT FOLKS WILL 1133 00:57:43,560 --> 00:57:46,000 COME UP NOT ONLY WITH THEIR 1134 00:57:46,000 --> 00:57:49,440 EXCITING STORIES AND NEW CASES 1135 00:57:49,440 --> 00:57:54,760 BUT ALSO NICE RECIPES AS WE ARE 1136 00:57:54,760 --> 00:57:58,240 CALLING IT ANTIDOTALLY THAT 1137 00:57:58,240 --> 00:58:00,720 PEOPLE CAN USE BY THE LARGER 1138 00:58:00,720 --> 00:58:01,520 COMMUNITY. 1139 00:58:01,520 --> 00:58:02,680 >>THANK YOU SO MUCH. 1140 00:58:02,680 --> 00:58:04,160 AND THANK YOU EVERYONE. 1141 00:58:04,160 --> 00:58:05,920 IT'S NOW MY PLEASURE TO 1142 00:58:05,920 --> 00:58:08,600 INTRODUCE THE MODERATOR FOR OUR 1143 00:58:08,600 --> 00:58:11,240 NEXT PANEL DR. SHEENAH MASAHIRO 1144 00:58:11,240 --> 00:58:17,160 TANAKA THE ASSOCIATE PROFESSOR 1145 00:58:17,160 --> 00:58:20,320 AT NYU SCHOOL OF MEDICINE. 1146 00:58:20,320 --> 00:58:22,080 SO THANK YOU SO MUCH FOR JOINING 1147 00:58:22,080 --> 00:58:24,520 US TODAY AND MODERATING OUR NEXT 1148 00:58:24,520 --> 00:58:27,600 PANEL AND OUR NEXT PANEL IS ON 1149 00:58:27,600 --> 00:58:29,040 INTEGRATION TECHNOLOGIES TO 1150 00:58:29,040 --> 00:58:30,880 ADVANCE HUMAN HEALTH. 1151 00:58:30,880 --> 00:58:33,240 >>THANK YOU VERY MUCH, SUSAN 1152 00:58:33,240 --> 00:58:35,960 FOR THAT NICE INTRODUCTION AND 1153 00:58:35,960 --> 00:58:37,960 HELLO, EVERYONE AND WELCOME TO 1154 00:58:37,960 --> 00:58:40,440 OUR PANELISTS WHICH ARE WE'RE 1155 00:58:40,440 --> 00:58:43,040 GOING TO BE DOING THE DATA 1156 00:58:43,040 --> 00:58:44,160 INTEGRATION TECHNOLOGIES FOR 1157 00:58:44,160 --> 00:58:45,680 ADVANCING HUMAN HEALTH. 1158 00:58:45,680 --> 00:58:48,760 AND I WANT TO INTRODUCE OUR TWO 1159 00:58:48,760 --> 00:58:50,240 PANELISTS. 1160 00:58:50,240 --> 00:58:52,240 OMAR HARB FROM THE UNIVERSITY OF 1161 00:58:52,240 --> 00:58:53,200 PENNSYLVANIA. 1162 00:58:53,200 --> 00:58:56,960 AND MICHAEL HAWRYLYCZ FROM THE 1163 00:58:56,960 --> 00:58:58,640 ALLEN INSTITUTE FOR BRAIN 1164 00:58:58,640 --> 00:58:59,200 SCIENCE. 1165 00:58:59,200 --> 00:59:01,880 I KNOW THIS IS GOING TO BE AN 1166 00:59:01,880 --> 00:59:03,600 INCREDIBLY INTERESTING PANEL. 1167 00:59:03,600 --> 00:59:07,720 THESE ARE TWO AWARDS THAT WERE 1168 00:59:07,720 --> 00:59:10,560 GIVEN FOR TEAM EFFORTS IN TERMS 1169 00:59:10,560 --> 00:59:14,520 OF DATA REUSE AND THIS IS A HUGE 1170 00:59:14,520 --> 00:59:18,600 AREA OF IMPORTANCE FOR THE 1171 00:59:18,600 --> 00:59:19,960 BIOINFORMATICS AND THE 1172 00:59:19,960 --> 00:59:20,680 SCIENTIFIC COMMUNITY. 1173 00:59:20,680 --> 00:59:23,080 SO I WELCOME BOTH OF YOU AND NOW 1174 00:59:23,080 --> 00:59:25,440 I WILL INTRODUCE OMAR WHO WILL 1175 00:59:25,440 --> 00:59:27,760 BE OUR FIRST SPEAKER AND OMAR IS 1176 00:59:27,760 --> 00:59:31,440 GOING TO BE TELLING US ABOUT THE 1177 00:59:31,440 --> 00:59:34,760 PATHOGEN VECTOR AND HOST 1178 00:59:34,760 --> 00:59:36,320 INFORMATICS RESOURCE WHICH 1179 00:59:36,320 --> 00:59:40,000 PROVIDES A WONDERFUL INTEGRATION 1180 00:59:40,000 --> 00:59:40,760 OF DATA. 1181 00:59:40,760 --> 00:59:43,040 THIS IS A LARGE TEAM. 1182 00:59:43,040 --> 00:59:46,920 I MENTIONED THAT THERE WERE 1183 00:59:46,920 --> 00:59:48,240 ALMOST 60 PEOPLE INVOLVED IN 1184 00:59:48,240 --> 00:59:49,800 THIS. 1185 00:59:49,800 --> 00:59:51,160 VERY INTERESTED TO HEAR ABOUT 1186 00:59:51,160 --> 00:59:51,360 THIS. 1187 00:59:51,360 --> 00:59:53,440 THANK YOU. 1188 00:59:53,440 --> 00:59:53,720 >>GREAT. 1189 00:59:53,720 --> 00:59:55,040 THANK YOU, SHEENAH. 1190 00:59:55,040 --> 00:59:57,280 IT'S GREAT TO BE HERE. 1191 00:59:57,280 --> 00:59:59,280 AND AS INDICATED I'M 1192 00:59:59,280 --> 01:00:01,280 REPRESENTING A LARGE TEAM. 1193 01:00:01,280 --> 01:00:03,720 I WAS FORTUNATE TO HAVE A NUMBER 1194 01:00:03,720 --> 01:00:05,200 OF TEAM MEMBERS ON THE DATA 1195 01:00:05,200 --> 01:00:08,360 WORKS CHALLENGE. 1196 01:00:08,360 --> 01:00:12,760 THOSE INCLUDE DAVID BRUCE AND 1197 01:00:12,760 --> 01:00:18,640 MARY ANN DOWEL. 1198 01:00:18,640 --> 01:00:20,560 SO BUILDING ON THE PREVIOUS 1199 01:00:20,560 --> 01:00:23,040 PANEL IT'S ACTUALLY I HAVE TO 1200 01:00:23,040 --> 01:00:25,360 SAY IN THE WORLD OF GENOMICS 1201 01:00:25,360 --> 01:00:27,600 WE'VE BEEN A LITTLE BIT 1202 01:00:27,600 --> 01:00:29,440 FORTUNATE MAYBE A LITTLE BIT 1203 01:00:29,440 --> 01:00:33,920 SPOILED THAT NIAID HAD A VISION 1204 01:00:33,920 --> 01:00:39,240 ALMOST 20 YEARS AGO TO SUPPORT 1205 01:00:39,240 --> 01:00:39,680 THIS. 1206 01:00:39,680 --> 01:00:47,600 THEY FUNDED THIS WRE MECHANISM D 1207 01:00:47,600 --> 01:00:51,560 WE'VE BEEN FORTUNATE TO BE 1208 01:00:51,560 --> 01:00:53,720 SUCCESSFUL IN RECEIVING FUNDING 1209 01:00:53,720 --> 01:00:56,120 FOR THIS RESOURCE CENTER TO 1210 01:00:56,120 --> 01:00:57,680 SUPPORT ORGANISMS THAT ARE 1211 01:00:57,680 --> 01:00:59,880 INCLUDED IN OUR RESOURCE. 1212 01:00:59,880 --> 01:01:04,360 THE OTHER THING TO POINT OUT IS 1213 01:01:04,360 --> 01:01:06,920 THAT IN THE GENOMIC WORLD THE 1214 01:01:06,920 --> 01:01:09,360 IDEA OF DATA SHARING BECAME 1215 01:01:09,360 --> 01:01:11,280 ALMOST A REQUIREMENT EARLY ON 1216 01:01:11,280 --> 01:01:14,360 WITH THE AVAILABILITY OF 1217 01:01:14,360 --> 01:01:15,000 REPOSITORIES. 1218 01:01:15,000 --> 01:01:17,960 THOSE ARE SUPER IMPORTANT TO 1219 01:01:17,960 --> 01:01:19,680 HAVE STRUCTURED AND WELL 1220 01:01:19,680 --> 01:01:20,880 ESTABLISHED REPOSITORIES. 1221 01:01:20,880 --> 01:01:26,480 AND WE HAVE SUCH REPOSITORIES. 1222 01:01:26,480 --> 01:01:29,480 CURRENTLY THERE ARE TWO CENTERS 1223 01:01:29,480 --> 01:01:33,640 FUNDED BY NIAID. 1224 01:01:33,640 --> 01:01:35,840 THESE INCLUDE BACTERIAL AND 1225 01:01:35,840 --> 01:01:37,720 VIRAL PATHOGENS. 1226 01:01:37,720 --> 01:01:46,760 IF YOU WORK ON THESE ORGANISMS 1227 01:01:46,760 --> 01:01:57,000 AND I ENCOURAGE YOU TO VISIT. 1228 01:01:57,000 --> 01:02:00,600 SO THE ORGANISMS THAT WE SUPPORT 1229 01:02:00,600 --> 01:02:02,600 STAND DIFFERENT ASPECTS OF THE 1230 01:02:02,600 --> 01:02:05,160 TREE OF LIFE INCLUDING MANY THAT 1231 01:02:05,160 --> 01:02:09,880 CAUSE DISEASE -- IN HUMANS SUCH 1232 01:02:09,880 --> 01:02:14,480 AS -- MALARIA. 1233 01:02:14,480 --> 01:02:19,440 AND FUNGAL ORGANISMS AND MANY 1234 01:02:19,440 --> 01:02:24,280 OTHER PARASITIC ORGANISMS. 1235 01:02:24,280 --> 01:02:27,600 AND ALSO VECTORS OF THOSE 1236 01:02:27,600 --> 01:02:31,600 ORGANISMS SUCH AS MOSQUITOES AND 1237 01:02:31,600 --> 01:02:32,160 TICKS. 1238 01:02:32,160 --> 01:02:35,480 THESE DISEASES TOGETHER CAUSE 1239 01:02:35,480 --> 01:02:37,480 MILLIONS OF DEATHS AND SICKNESS 1240 01:02:37,480 --> 01:02:39,440 ALL OVER THE WORLD AND MANY ARE 1241 01:02:39,440 --> 01:02:41,800 ALSO IMPORTANT NOT ONLY IN THE 1242 01:02:41,800 --> 01:02:44,240 GLOBAL SOUTH BUT ALSO IN 1243 01:02:44,240 --> 01:02:46,800 NORTHERN AND WESTERN COUNTRIES 1244 01:02:46,800 --> 01:02:55,000 INCLUDING THINGS LIKE -- A 1245 01:02:55,000 --> 01:02:57,440 PATHOGEN IN THE NORTHEAST 1246 01:02:57,440 --> 01:03:03,040 CARRIED BY TICKS. 1247 01:03:03,040 --> 01:03:08,200 AND MANY OTHER FUNGAL ORGANISMS 1248 01:03:08,200 --> 01:03:13,280 SUCH AS CANADA WHICH IS A 1249 01:03:13,280 --> 01:03:16,080 IMPORTANT -- DISEASE. 1250 01:03:16,080 --> 01:03:20,080 THEY ARE BASICALLY FILTERS ON 1251 01:03:20,080 --> 01:03:22,400 THE SITE FILTERED AND TAILORED 1252 01:03:22,400 --> 01:03:24,520 TO THE VARIOUS COMMITTEES THAT 1253 01:03:24,520 --> 01:03:29,360 WE SUPPORT. 1254 01:03:29,360 --> 01:03:34,000 SO FOR EXAMPLE IT'S FILTERED TO 1255 01:03:34,000 --> 01:03:44,400 INCLUDE THESE ORGANISMS. 1256 01:03:44,920 --> 01:03:48,360 SO OUR GOAL IS TO INTEGRATE DATA 1257 01:03:48,360 --> 01:03:49,560 BIG DATA. 1258 01:03:49,560 --> 01:03:53,760 AND SHOWING YOU JUST A LISTING. 1259 01:03:53,760 --> 01:03:57,480 AND THE GOAL IS NOT TO SIMPLY BE 1260 01:03:57,480 --> 01:03:59,760 A REPOSITORY BECAUSE THERE ARE 1261 01:03:59,760 --> 01:04:02,000 SOME REALLY GOOD REPOSITORIES 1262 01:04:02,000 --> 01:04:04,480 OUT THERE BUT OUR GOAL IS TO 1263 01:04:04,480 --> 01:04:06,600 PROVIDE THE SCIENTISTS OUR 1264 01:04:06,600 --> 01:04:09,120 CLIENTS WITH A MECHANISM TO 1265 01:04:09,120 --> 01:04:10,720 INTERROGATE THIS DATA IN A WAY 1266 01:04:10,720 --> 01:04:13,840 THAT IS MEANINGFUL TO THEM AND 1267 01:04:13,840 --> 01:04:20,880 ALLOWS THEM TO DEVELOP NEW 1268 01:04:20,880 --> 01:04:23,160 HYPOTHESIS. 1269 01:04:23,160 --> 01:04:25,280 METADATA IS ALMOST A BAD WORD 1270 01:04:25,280 --> 01:04:27,760 BECAUSE IT'S REALLY DATA. 1271 01:04:27,760 --> 01:04:29,560 DATA ABOUT DATA AND THERE IS A 1272 01:04:29,560 --> 01:04:32,120 LOT OF IT AND IT NEEDS TO BE 1273 01:04:32,120 --> 01:04:33,240 STRUCTURED AND PROPERLY 1274 01:04:33,240 --> 01:04:34,840 INTEGRATED. 1275 01:04:34,840 --> 01:04:37,320 AND WE USE ONCOLOGY TO STRUCTURE 1276 01:04:37,320 --> 01:04:39,680 AND DID DESCRIBE THIS DATA AND 1277 01:04:39,680 --> 01:04:41,760 INTEGRATE IT INTO STRUCTURED 1278 01:04:41,760 --> 01:04:44,560 DATABASES THAT WE CAN THEN QUERY 1279 01:04:44,560 --> 01:04:49,320 AND GET INFORMATION FROM. 1280 01:04:49,320 --> 01:04:51,320 AN IMPORTANT ASPECT IS COMMUNITY 1281 01:04:51,320 --> 01:04:53,560 ENGAGEMENT AND THIS ENGAGEMENT 1282 01:04:53,560 --> 01:04:58,080 ALLOWS US TO IDENTIFY IMPORTANT 1283 01:04:58,080 --> 01:04:59,640 DATASETS, PRIORITIZE THEM FOR 1284 01:04:59,640 --> 01:05:00,160 LOADING. 1285 01:05:00,160 --> 01:05:02,320 A BIG PORTION OF BEING ABLE TO 1286 01:05:02,320 --> 01:05:03,960 PRESENT AND PROVIDE DATA 1287 01:05:03,960 --> 01:05:05,880 EFFECTIVELY IS TO PROPERLY 1288 01:05:05,880 --> 01:05:06,880 DESCRIBE IT. 1289 01:05:06,880 --> 01:05:09,520 THE METADATA AND MAKE SURE THE 1290 01:05:09,520 --> 01:05:11,360 SAMPLES ARE PROPERLY DESCRIBED. 1291 01:05:11,360 --> 01:05:15,680 SO THAT QUERIES CAN BE PERFORMED 1292 01:05:15,680 --> 01:05:18,400 AGAINST THESE DATASETS SO THAT 1293 01:05:18,400 --> 01:05:19,880 PROPER INFORMATION CAN BE 1294 01:05:19,880 --> 01:05:20,360 ACCESSED. 1295 01:05:20,360 --> 01:05:22,360 IN ADDITION TO PROVIDING THE 1296 01:05:22,360 --> 01:05:24,560 DESCRIPTIONS OF THE DATA AND 1297 01:05:24,560 --> 01:05:25,480 INTEGRATING IT AND PROVIDING 1298 01:05:25,480 --> 01:05:27,840 TOOLS TO ANALYZE THIS DATA WE GO 1299 01:05:27,840 --> 01:05:30,560 THROUGH A RIGOROUS PROCESS OF 1300 01:05:30,560 --> 01:05:31,320 QUALITY CONTROL. 1301 01:05:31,320 --> 01:05:34,320 THIS IS SHOWING YOU A SNIPPET AT 1302 01:05:34,320 --> 01:05:36,520 THE END OF LAST YEAR. 1303 01:05:36,520 --> 01:05:39,920 THREE RELEASES AND EACH INCLUDES 1304 01:05:39,920 --> 01:05:42,200 EVERY ASPECT THAT IS SHOWN HERE 1305 01:05:42,200 --> 01:05:44,800 ON THE LEFT INCLUDING THE FINAL 1306 01:05:44,800 --> 01:05:47,560 QA OF THE DATASETS. 1307 01:05:47,560 --> 01:05:51,520 IN ORDER FOR US TO BE EFFECTIVE 1308 01:05:51,520 --> 01:05:53,320 WE HAVE TO BUILD COMMUNITY TRUST 1309 01:05:53,320 --> 01:05:55,160 AND WE DO THIS THROUGH MANY 1310 01:05:55,160 --> 01:05:55,680 WAYS. 1311 01:05:55,680 --> 01:05:58,560 SOME OF THE ASPECTS IS FIRST OF 1312 01:05:58,560 --> 01:06:01,320 ALL MAKING SURE THAT WE'RE 1313 01:06:01,320 --> 01:06:04,200 ACCURATING DESCRIBING THE DATA. 1314 01:06:04,200 --> 01:06:06,400 MAKING SURE WE COMMUNICATE WITH 1315 01:06:06,400 --> 01:06:08,480 PROVIDERS OF DATA AND THE 1316 01:06:08,480 --> 01:06:10,840 DATASETS THAT WE LOAD EVEN 1317 01:06:10,840 --> 01:06:13,080 PUBLISHED LATE A WE COMMUNICATE 1318 01:06:13,080 --> 01:06:14,560 TO MAKE SURE THEY ARE PARTNERS 1319 01:06:14,560 --> 01:06:16,560 WITH US AS WE LOAD AND INTEGRATE 1320 01:06:16,560 --> 01:06:19,600 THE DATA. AND THE QA PROCESS IS 1321 01:06:19,600 --> 01:06:21,280 RIGOROUS AND THAT ALSO INCLUDES 1322 01:06:21,280 --> 01:06:22,720 THE COMMUNITY. 1323 01:06:22,720 --> 01:06:25,240 THAT OUR COMMUNITY PARTNERS ARE 1324 01:06:25,240 --> 01:06:29,320 QAING THE DATA TO MAKE SURE THEY 1325 01:06:29,320 --> 01:06:34,080 ARE HAPPY WITH THE RESULTS. 1326 01:06:34,080 --> 01:06:35,920 THE IDEA IS TO MAKE SURE THAT WE 1327 01:06:35,920 --> 01:06:37,720 HAVE A TRUSTED RELATIONSHIP WITH 1328 01:06:37,720 --> 01:06:38,320 OUR COMMUNITY. 1329 01:06:38,320 --> 01:06:40,480 ALL OF THESE ARE IMPORTANT AND 1330 01:06:40,480 --> 01:06:42,280 OBVIOUSLY ALLOWS YOU TO THEN 1331 01:06:42,280 --> 01:06:44,760 FIND THE DATA. 1332 01:06:44,760 --> 01:06:47,760 YOU CAN GO IN AND QUERY AND FIND 1333 01:06:47,760 --> 01:06:49,720 DATASETS BASED ON KEY WORDS. 1334 01:06:49,720 --> 01:06:52,480 THIS IS ALL WELL AND GOOD. 1335 01:06:52,480 --> 01:06:55,240 BUT THIS IS ALMOST USELESS IF 1336 01:06:55,240 --> 01:06:57,240 YOU CAN KNOT SEARCH EFFECTIVELY 1337 01:06:57,240 --> 01:06:58,400 AND INTEGRATE IT. 1338 01:06:58,400 --> 01:07:00,440 AND FOR THIS WHAT OUR TEAM HAS 1339 01:07:00,440 --> 01:07:02,120 DONE IS WE'VE INTEGRATED THIS 1340 01:07:02,120 --> 01:07:04,560 DATA IN USING STRUCTURED 1341 01:07:04,560 --> 01:07:06,320 SEARCHES USING WEB INTERFACES 1342 01:07:06,320 --> 01:07:11,720 AND THE IDEA IS THE STANDARD 1343 01:07:11,720 --> 01:07:13,840 SCIENTIST JUST LIKE ME, I WORKED 1344 01:07:13,840 --> 01:07:17,040 MOST OF MY ADULT LIFE IN A LAB. 1345 01:07:17,040 --> 01:07:21,960 AND I NEVER KNEW ANYTHING ABOUT 1346 01:07:21,960 --> 01:07:24,960 COMPUTATIONAL BIOLOGY AND OUR 1347 01:07:24,960 --> 01:07:27,400 PHILOSOPHY IS MAKING SURE THAT 1348 01:07:27,400 --> 01:07:28,800 IT'S ACCESSIBLE. 1349 01:07:28,800 --> 01:07:31,040 TO LOOK FOR A PARTICULAR DATA 1350 01:07:31,040 --> 01:07:32,160 TYPE OR PARTICULAR SEARCH. 1351 01:07:32,160 --> 01:07:34,240 AND THEN RUN THE SEARCHES. 1352 01:07:34,240 --> 01:07:37,440 HOWEVER, AN ADDED LAYER AND THIS 1353 01:07:37,440 --> 01:07:42,640 IS A HUGE INNOVATION -- THAT IS 1354 01:07:42,640 --> 01:07:44,000 BUILDING SOMETHING CALLED A 1355 01:07:44,000 --> 01:07:44,880 SEARCH STRATEGY. 1356 01:07:44,880 --> 01:07:46,880 THIS IS A MECHANISM WHERE YOU 1357 01:07:46,880 --> 01:07:49,960 CAN RUN VARIOUS SEARCHES AND 1358 01:07:49,960 --> 01:07:51,240 INTEGRATE THEM TOGETHER TO COME 1359 01:07:51,240 --> 01:07:54,360 UP WITH LISTS OF RESULTS AND IN 1360 01:07:54,360 --> 01:07:56,160 THIS CASE GENES THAT ALLOW YOU 1361 01:07:56,160 --> 01:08:00,920 TO BUILD NOVEL HYPOTHESIS AND GO 1362 01:08:00,920 --> 01:08:03,000 BACK TO THE LAB AND TEST THEM. 1363 01:08:03,000 --> 01:08:05,000 ONE THAT YOU'RE INTEGRATING 1364 01:08:05,000 --> 01:08:07,240 RESULTS FROM DIFFERENT 1365 01:08:07,240 --> 01:08:08,360 EXPERIMENTS AND THE SECOND IS 1366 01:08:08,360 --> 01:08:10,120 THAT YOU'RE INTEGRATING 1367 01:08:10,120 --> 01:08:11,760 DIFFERENT TYPES OF RESULTS. 1368 01:08:11,760 --> 01:08:14,440 SO WE'RE INTEGRATING RESULTS 1369 01:08:14,440 --> 01:08:24,920 FROM AN ANALYSIS ON A GENOME. 1370 01:08:25,320 --> 01:08:26,480 CRISPR SCREENS. 1371 01:08:26,480 --> 01:08:30,680 YOUR OWN ANALYZED DATA AND 1372 01:08:30,680 --> 01:08:34,200 ADDING HERE POST TRANSITIONAL 1373 01:08:34,200 --> 01:08:34,800 MODIFICATION SEARCH. 1374 01:08:34,800 --> 01:08:39,400 WE HAVE A HUGE LIST OF YouTube 1375 01:08:39,400 --> 01:08:42,040 TUTORIALS. 1376 01:08:42,040 --> 01:08:43,840 THE WAY THIS WORKS IS SHOWING 1377 01:08:43,840 --> 01:08:44,480 YOU HERE. 1378 01:08:44,480 --> 01:08:46,280 YOU GO A FIND THE SEARCH THAT 1379 01:08:46,280 --> 01:08:47,480 YOU'RE INTERESTED IN. 1380 01:08:47,480 --> 01:08:49,160 RUN YOUR FIRST SEARCH. 1381 01:08:49,160 --> 01:08:51,080 SELECT THE ORGANISM OF INTEREST 1382 01:08:51,080 --> 01:08:53,000 AND THEN START YOUR FIRST 1383 01:08:53,000 --> 01:08:54,760 STRATEGY WHICH INCLUDES THE 1384 01:08:54,760 --> 01:08:57,320 FIRST STEP. 1385 01:08:57,320 --> 01:08:59,200 AND THEN YOU ADD STEPS AND 1386 01:08:59,200 --> 01:09:00,760 SEARCH FOR ADDITIONAL SEARCHES 1387 01:09:00,760 --> 01:09:01,360 RIGHT HERE. 1388 01:09:01,360 --> 01:09:03,760 YOU DECIDE HOW YOU'RE GOING TO 1389 01:09:03,760 --> 01:09:06,200 JOIN WITH EACH OTHER AND WITH 1390 01:09:06,200 --> 01:09:08,120 DIFFERENT OPERATIONS AND AS YOU 1391 01:09:08,120 --> 01:09:09,800 BUILD THIS STRATEGY YOU KEEP 1392 01:09:09,800 --> 01:09:11,880 GOING AND GOING AND YOU BUILD 1393 01:09:11,880 --> 01:09:14,120 THIS INTO AN EXPERIMENT THAT 1394 01:09:14,120 --> 01:09:16,240 GIVES YOU RESULTS THAT YOU ARE 1395 01:09:16,240 --> 01:09:17,400 GO BACK AND TEST AND YOU CAN 1396 01:09:17,400 --> 01:09:20,120 LOOK AT THESE RESULTS AND 1397 01:09:20,120 --> 01:09:22,760 ANALYZE THEM DIFFERENT WAYS AND 1398 01:09:22,760 --> 01:09:28,160 TAKE THEM A STEP FURTHER. 1399 01:09:28,160 --> 01:09:35,400 W IF YOU WANT TO BROWSE OR LOOK 1400 01:09:35,400 --> 01:09:37,560 AT EXPRESSION PROFILES OR 1401 01:09:37,560 --> 01:09:39,560 PHENOTYPE PROFILES FOR A GENOME 1402 01:09:39,560 --> 01:09:42,320 OR LOOKING AT THE LOCATION OF 1403 01:09:42,320 --> 01:09:43,400 VARIOUS ISOLATES. 1404 01:09:43,400 --> 01:09:45,480 IN THIS CASE LOOKING AT 1405 01:09:45,480 --> 01:09:46,800 MOSQUITOES IN DIFFERENT PARTS OF 1406 01:09:46,800 --> 01:09:50,840 THE WORLD AND WHETHER THEY ARE 1407 01:09:50,840 --> 01:09:52,560 INFECTED OR NOT. 1408 01:09:52,560 --> 01:09:55,880 YOU CAN LOOK AT A MAP THAT IS 1409 01:09:55,880 --> 01:10:01,280 EXPLORABLE WHICH IS REALLY COOL. 1410 01:10:01,280 --> 01:10:03,480 AND OF COURSE IT'S NICE TO BE 1411 01:10:03,480 --> 01:10:06,920 ABLE TO SEE THAT DATABASES ARE 1412 01:10:06,920 --> 01:10:09,360 USED AND WE HAVE -- WE'RE ACTIVE 1413 01:10:09,360 --> 01:10:12,040 ON VARIOUS SOCIAL MEDIA TO STAY 1414 01:10:12,040 --> 01:10:14,000 IN TOUCH WITH OUR COMMUNITIES. 1415 01:10:14,000 --> 01:10:16,040 WE ALSO PROVIDE TOOLS TO ANALYZE 1416 01:10:16,040 --> 01:10:18,360 YOUR OWN DATA AND INTEGRATE IT. 1417 01:10:18,360 --> 01:10:20,720 WE TAKE ADVANTAGE OF A TOOL 1418 01:10:20,720 --> 01:10:22,240 CALLED GALAXY. 1419 01:10:22,240 --> 01:10:24,640 WHICH ALLOWS YOU TO UPLOAD YOUR 1420 01:10:24,640 --> 01:10:26,440 OWN DATA. 1421 01:10:26,440 --> 01:10:28,640 AGAIN USER INTERFACE. 1422 01:10:28,640 --> 01:10:31,920 AND TAKE THE RESULTS AND BRING 1423 01:10:31,920 --> 01:10:39,720 THEM BACK IN AND GO ON 1424 01:10:39,720 --> 01:10:40,680 ENRICHMENTS OR RUN STRUCTURED 1425 01:10:40,680 --> 01:10:42,120 SEARCHES. 1426 01:10:42,120 --> 01:10:43,560 I WANT TO GO BACK TO THE 1427 01:10:43,560 --> 01:10:44,960 COMMUNITY ENGAGEMENT. 1428 01:10:44,960 --> 01:10:46,760 LISTENING TO THE COMMUNITY IS 1429 01:10:46,760 --> 01:10:47,240 IMPORTANT. 1430 01:10:47,240 --> 01:10:48,800 THIS ALLOWS US TO KNOW WHAT IS 1431 01:10:48,800 --> 01:10:49,440 COMING. 1432 01:10:49,440 --> 01:10:51,080 WHAT DATASETS ARE IMPORTANT. 1433 01:10:51,080 --> 01:10:54,000 BECAUSE MAKING SURE THAT THESE 1434 01:10:54,000 --> 01:10:55,320 DATASETS ARE AVAILABLE AS SOON 1435 01:10:55,320 --> 01:10:58,760 AS POSSIBLE MAKES THEM, GIVES 1436 01:10:58,760 --> 01:11:01,400 THEM A LONGER SHELF LIFE. 1437 01:11:01,400 --> 01:11:04,280 IMAGINE THE RETURN ON 1438 01:11:04,280 --> 01:11:04,560 INVESTMENT. 1439 01:11:04,560 --> 01:11:06,280 WE HAVE DATASETS THAT HAVE BEEN 1440 01:11:06,280 --> 01:11:10,040 LOADED IN OUR DATABASES ALMOST 1441 01:11:10,040 --> 01:11:12,520 20 YEARS AGO AND THEY ARE STILL 1442 01:11:12,520 --> 01:11:14,840 BEING USED. 1443 01:11:14,840 --> 01:11:16,520 THIS IS HUGE. 1444 01:11:16,520 --> 01:11:18,840 SO I THINK MORE OF THAT IS SUPER 1445 01:11:18,840 --> 01:11:19,360 IMPORTANT. 1446 01:11:19,360 --> 01:11:21,560 WE HEAR FROM OUR COMMUNITY. 1447 01:11:21,560 --> 01:11:23,520 THEY VIEW US AS PARTNERS. 1448 01:11:23,520 --> 01:11:26,520 WE VIEW THEM AS PARTNERS AS WELL 1449 01:11:26,520 --> 01:11:28,640 AND THEY TELL US WHEN WE'RE 1450 01:11:28,640 --> 01:11:30,120 DOING SOMETHING WRONG OR RIGHT 1451 01:11:30,120 --> 01:11:33,440 AND THEY GIVE US ADVICE ON WHAT 1452 01:11:33,440 --> 01:11:34,960 FEATURES THEY WANT. 1453 01:11:34,960 --> 01:11:38,080 WE HAVE A STRONG EDUCATIONAL ARM 1454 01:11:38,080 --> 01:11:40,440 WHERE WE RUN BOTH IN PERSON AND 1455 01:11:40,440 --> 01:11:43,400 VIRTUAL WORKSHOPS AND MULTIPLE 1456 01:11:43,400 --> 01:11:46,000 YouTube AND WEBINAR. 1457 01:11:46,000 --> 01:11:48,680 SO I RECOMMEND TO GO TO OUR 1458 01:11:48,680 --> 01:11:55,800 YouTube CHANNEL TO EXPLORE OUR 1459 01:11:55,800 --> 01:11:56,560 WORKSHOPS. 1460 01:11:56,560 --> 01:11:57,920 WE RECORD EVERYTHING. 1461 01:11:57,920 --> 01:12:00,640 HERE IS A SNIPPET. 1462 01:12:00,640 --> 01:12:03,760 AND YOU CAN SEE THAT WE HAVE A 1463 01:12:03,760 --> 01:12:06,000 GOOD REPRESENTATION ACROSS THE 1464 01:12:06,000 --> 01:12:07,960 WORLD AND HERE IS AN EXAMPLE. 1465 01:12:07,960 --> 01:12:09,760 WE HAVE ACCESS FROM ALL OVER THE 1466 01:12:09,760 --> 01:12:11,880 WORLD DURING THE WORKSHOP WHICH 1467 01:12:11,880 --> 01:12:14,720 IS REALLY GREAT AND NICE TO SEE. 1468 01:12:14,720 --> 01:12:16,920 YOU WANT TO MAKE SURE THAT YOUR 1469 01:12:16,920 --> 01:12:19,120 DATABASE IS BEING USED AND IT'S 1470 01:12:19,120 --> 01:12:23,240 NICE TO SEE THE CITATIONS. 1471 01:12:23,240 --> 01:12:26,720 SO I'M SHOWING A SNIPPET. 1472 01:12:26,720 --> 01:12:29,400 OUR CITATIONS ARE GOING UP AND 1473 01:12:29,400 --> 01:12:32,960 WE'RE UP TO ABOUT 2500 CITATIONS 1474 01:12:32,960 --> 01:12:34,520 ANNUALLY. 1475 01:12:34,520 --> 01:12:38,680 SO, THAT IS VERY GOOD AND MANY 1476 01:12:38,680 --> 01:12:40,960 ARE QUITE NICE TO READ BECAUSE 1477 01:12:40,960 --> 01:12:44,880 THEY ARE HEAVILY USED RESOURCE 1478 01:12:44,880 --> 01:12:47,480 TO DRIVE THE HYPOTHESIS THAT 1479 01:12:47,480 --> 01:12:49,280 THEY ARE TESTING THEM IN THE 1480 01:12:49,280 --> 01:12:51,240 PAPERS AND GENERATING NEW DATA 1481 01:12:51,240 --> 01:12:55,720 AND COMES BACK AND CONTRIBUTES 1482 01:12:55,720 --> 01:12:57,120 TO THE RESOURCE. 1483 01:12:57,120 --> 01:12:59,080 THIS WILL ITERATE THAT THIS 1484 01:12:59,080 --> 01:13:04,080 MECHANISM OF DATA DATASETS FROM 1485 01:13:04,080 --> 01:13:06,120 REPOSITORIES OR DIRECTLY FROM 1486 01:13:06,120 --> 01:13:08,640 SCIENTISTS TAKING THEM INTO A 1487 01:13:08,640 --> 01:13:10,320 STRUCTURED REPOSITORY WHERE YOU 1488 01:13:10,320 --> 01:13:14,080 CAN DESCRIBE THE DATA AND PUT 1489 01:13:14,080 --> 01:13:15,680 MAKE SURE IT'S QUALITY ASSURED 1490 01:13:15,680 --> 01:13:19,080 AND BUILDING A USER INTERFACE TO 1491 01:13:19,080 --> 01:13:30,160 MINE AND CARY CARE -- CA-QUERY. 1492 01:13:31,600 --> 01:13:31,960 *. 1493 01:13:31,960 --> 01:13:37,360 THIS HAS MADE US INTO A TRUSTED 1494 01:13:37,360 --> 01:13:40,880 RESOURCE AND MAKES IT USEFUL FOR 1495 01:13:40,880 --> 01:13:42,120 EVERYONE. 1496 01:13:42,120 --> 01:13:45,000 I'LL CONCLUDE AGAIN BY 1497 01:13:45,000 --> 01:13:48,520 HIGHLIGHTING MY TEAMMATES WHO 1498 01:13:48,520 --> 01:13:49,800 HAVE BEEN INSTRUMENTAL AND 1499 01:13:49,800 --> 01:13:53,240 HIGHLIGHTING THE SOFTWARE 1500 01:13:53,240 --> 01:13:54,880 ENGINEERS AND OTHER SCIENTISTS 1501 01:13:54,880 --> 01:13:56,400 WHO HAVE BEEN WORKING WITH US. 1502 01:13:56,400 --> 01:13:58,440 MOST OF THE PEOPLE OF ARE, THEIR 1503 01:13:58,440 --> 01:14:00,200 JOB IS TO WORK FOR THESE 1504 01:14:00,200 --> 01:14:01,000 RESOURCES. 1505 01:14:01,000 --> 01:14:03,440 THEY ARE NOT POSTDOCS OR 1506 01:14:03,440 --> 01:14:05,200 GRADUATE STUDENTS AND THAT GIVES 1507 01:14:05,200 --> 01:14:07,320 US A NICE EDGE AND ADDRESSES ONE 1508 01:14:07,320 --> 01:14:09,680 OF THE QUESTIONS THAT THERE 1509 01:14:09,680 --> 01:14:12,400 NEEDS TO BE THIS SUSTAINED 1510 01:14:12,400 --> 01:14:13,800 FUNDING FOR RESOURCES THAT 1511 01:14:13,800 --> 01:14:17,640 REALLY MAKE THE DATA ACCESSIBLE, 1512 01:14:17,640 --> 01:14:19,120 REPOSITORY IS IMPORTANT AND 1513 01:14:19,120 --> 01:14:20,920 ESSENTIAL BUT THE DATA NEEDS TO 1514 01:14:20,920 --> 01:14:24,160 BE ACCESSIBLE IN A WAY THAT IT 1515 01:14:24,160 --> 01:14:26,560 CAN BE INTERROGATED AND MADE 1516 01:14:26,560 --> 01:14:29,000 USEFUL FOR HYPOTHESIS 1517 01:14:29,000 --> 01:14:29,760 GENERATION. 1518 01:14:29,760 --> 01:14:31,120 I'LL END HERE. 1519 01:14:31,120 --> 01:14:33,120 THANK YOU VERY MUCH. 1520 01:14:33,120 --> 01:14:34,640 >>THANK YOU VERY MUCH OMAR. 1521 01:14:34,640 --> 01:14:37,720 THIS WAS TERRIFIC. 1522 01:14:37,720 --> 01:14:41,400 AND I KNOW THAT THERE WILL BE 1523 01:14:41,400 --> 01:14:42,840 MANY QUESTIONS BUT WE'RE GOING 1524 01:14:42,840 --> 01:14:44,600 TO HEAR FROM OUR NEXT SPEAKER 1525 01:14:44,600 --> 01:14:47,960 AGAIN. 1526 01:14:47,960 --> 01:14:50,480 THIS IS TRULY A WONDER. 1527 01:14:50,480 --> 01:14:54,440 EXAMPLE OF A GLOBAL RESOURCE. 1528 01:14:54,440 --> 01:14:56,880 AND NEXT WE'RE GOING TO HEAR 1529 01:14:56,880 --> 01:14:59,600 FROM MICHAEL HAWRYLYCZ FROM THE 1530 01:14:59,600 --> 01:15:02,200 ALLEN INSTITUTE FOR BRAIN 1531 01:15:02,200 --> 01:15:03,400 SCIENCE. 1532 01:15:03,400 --> 01:15:07,240 ABOUT THE CELL TYPE KNOWLEDGE 1533 01:15:07,240 --> 01:15:07,960 EXPLORER. 1534 01:15:07,960 --> 01:15:14,040 AGAIN A PUBLIC ACCESS ATLAS FOR 1535 01:15:14,040 --> 01:15:15,400 MULTI-MODEL SUBTYPE DATA. 1536 01:15:15,400 --> 01:15:19,600 THIS IS A REALLY FAST-MOVING 1537 01:15:19,600 --> 01:15:21,680 AREA PARTICULARLY IN TERMS OF 1538 01:15:21,680 --> 01:15:24,840 SINGLE CELL WORK. 1539 01:15:24,840 --> 01:15:26,960 AND VERY INTERESTED TO HEAR FROM 1540 01:15:26,960 --> 01:15:27,440 MICHAEL. 1541 01:15:27,440 --> 01:15:30,880 SO PLEASE, TAKE IT AWAY. 1542 01:15:30,880 --> 01:15:33,360 >>YOU CAN SEE MY PRESENTATION. 1543 01:15:33,360 --> 01:15:33,800 >>YES. 1544 01:15:33,800 --> 01:15:34,160 WE CAN 1545 01:15:34,160 --> 01:15:35,280 >>THANK YOU. 1546 01:15:35,280 --> 01:15:46,120 I'D LIKE TO THANK THE F FASEB AH 1547 01:15:53,960 --> 01:15:58,080 -- I'M GOING TO TALK ABOUT THIS 1548 01:15:58,080 --> 01:15:59,880 TOOL CALLED THE CELL TYPE 1549 01:15:59,880 --> 01:16:01,680 KNOWLEDGE EXPLORER BUT I'M ALSO 1550 01:16:01,680 --> 01:16:04,680 GOING TO TALK ABOUT HOW IT 1551 01:16:04,680 --> 01:16:05,680 INTERFACES WITH OTHER 1552 01:16:05,680 --> 01:16:06,920 TECHNOLOGIES THAT WE HAVE IN 1553 01:16:06,920 --> 01:16:09,040 TERMS OF DATA INTEGRATION FOR 1554 01:16:09,040 --> 01:16:12,080 HUMAN HEALTH. 1555 01:16:12,080 --> 01:16:14,720 SO A MAJOR KIND OF INITIATIVE OF 1556 01:16:14,720 --> 01:16:18,320 THE BRAIN INITIATIVE WAS THIS 1557 01:16:18,320 --> 01:16:29,040 BIG CONSORTIUM CALLED THE BRA -- 1558 01:16:30,200 --> 01:16:32,440 BRAIN INITIATIVE CELL NETWORK. 1559 01:16:32,440 --> 01:16:34,880 THIS WAS A LARGE CONSORTIUM 1560 01:16:34,880 --> 01:16:39,720 EFFORT TO PROFILE ALL OF THE 1561 01:16:39,720 --> 01:16:41,720 CELL TYPES OF THE MOUSE BRAIN 1562 01:16:41,720 --> 01:16:43,800 WITH PROTOTYPES DEVELOPED FOR 1563 01:16:43,800 --> 01:16:46,880 THE HUMAN AND THE ALSO NONHUMAN 1564 01:16:46,880 --> 01:16:47,240 PRIMATE. 1565 01:16:47,240 --> 01:16:51,360 IT RESULTED IN THE END IN REALLY 1566 01:16:51,360 --> 01:16:54,880 A BRAIN WIDE PROFILING OF THE 1567 01:16:54,880 --> 01:16:58,200 MOUSE BRAIN AND A DEEP DIVE INTO 1568 01:16:58,200 --> 01:17:00,920 SEVERAL AREAS. 1569 01:17:00,920 --> 01:17:04,200 IN 2021 THERE WAS A LARGE 1570 01:17:04,200 --> 01:17:08,440 ORCHESTRATED EFFORT OF SOME 1571 01:17:08,440 --> 01:17:12,840 OTHER PARTICIPANTS PLAYED AN 1572 01:17:12,840 --> 01:17:14,640 INTEGRAL PART INVOLVED IN 1573 01:17:14,640 --> 01:17:15,720 CHARACTERIZING THESE CELL TYPES 1574 01:17:15,720 --> 01:17:18,400 IN THE PRIMARY MOTOR CORTEX 1575 01:17:18,400 --> 01:17:19,720 ACROSS SPECIES. 1576 01:17:19,720 --> 01:17:23,760 SO THIS WAS A -- USING 1577 01:17:23,760 --> 01:17:28,200 TECHNOLOGY OF SINGLE CELL DATA 1578 01:17:28,200 --> 01:17:33,120 SPATIAL -- AND TECHNIQUES. 1579 01:17:33,120 --> 01:17:35,080 EPIGENETIC TECHNIQUES. 1580 01:17:35,080 --> 01:17:38,320 USE OF TRANSGENIC LINES IN TERMS 1581 01:17:38,320 --> 01:17:41,080 OF CHARACTERIZING AND DESCRIBING 1582 01:17:41,080 --> 01:17:42,520 THE RELATIONSHIPS AMONG THESE 1583 01:17:42,520 --> 01:17:43,320 CELL TYPES. 1584 01:17:43,320 --> 01:17:46,000 IT RESULTED IN AN ENTIRE ISSUE 1585 01:17:46,000 --> 01:17:51,200 OF NATURE IN OCTOBER OF 2021. 1586 01:17:51,200 --> 01:17:56,560 A RESULT OF THIS IS REALLY A 1587 01:17:56,560 --> 01:17:58,800 TOXONOMY OF CELL TYPES INITIALLY 1588 01:17:58,800 --> 01:18:02,000 IN THIS AREA IN THE PRIMARY 1589 01:18:02,000 --> 01:18:03,560 MORTAR CORTEX. 1590 01:18:03,560 --> 01:18:07,520 IT HAS BEEN EXTENDED NOW TO THE 1591 01:18:07,520 --> 01:18:08,640 ENTIRE BRAIN ALTHOUGH THE 1592 01:18:08,640 --> 01:18:10,240 ANNOTATION OF THAT IS STILL A 1593 01:18:10,240 --> 01:18:12,120 WORK IN PROGRESS. 1594 01:18:12,120 --> 01:18:14,680 BUT THIS PRESENTS THE TAXONOMY 1595 01:18:14,680 --> 01:18:17,520 IN THE MOTOR CORTEX SHOWING THE 1596 01:18:17,520 --> 01:18:21,160 DIFFERENT CELL TYPES FROM 1597 01:18:21,160 --> 01:18:26,480 NEURONAL TO NONNEURONAL, THE 1598 01:18:26,480 --> 01:18:33,480 CLASSICAL SUBTYPES THAT WE SEE. 1599 01:18:33,480 --> 01:18:36,360 AND WE ARE ABLE TO ACTUALLY LOOK 1600 01:18:36,360 --> 01:18:40,440 AT AND UNDERSTAND THE PROFILING 1601 01:18:40,440 --> 01:18:41,840 OF THESE NEURONS. 1602 01:18:41,840 --> 01:18:44,840 VARIOUS ASPECTS OF THEIR FIRING 1603 01:18:44,840 --> 01:18:46,840 PATTERNS AND OTHER ASPECTS. 1604 01:18:46,840 --> 01:18:49,440 ONE OF THE THINGS THAT WE DID AS 1605 01:18:49,440 --> 01:18:51,000 PART OF THIS WHICH WE RECEIVED 1606 01:18:51,000 --> 01:18:54,080 THE AWARD FOR WAS BUILDING OF 1607 01:18:54,080 --> 01:18:58,320 THIS SOFTWARE WHICH WE CALL THE 1608 01:18:58,320 --> 01:19:03,760 CELL TECHNICAL EXPLORER. 1609 01:19:03,760 --> 01:19:06,720 WHICH CAPTURES THE WORK AND THE 1610 01:19:06,720 --> 01:19:09,280 PROFILING OF THE PRIMARY MOTOR 1611 01:19:09,280 --> 01:19:10,040 CORTEX. 1612 01:19:10,040 --> 01:19:12,360 EMBEDS THE DATA ACROSS THE 1613 01:19:12,360 --> 01:19:14,240 SPECIES AND ALLOWS USERS TO 1614 01:19:14,240 --> 01:19:16,400 BROWSE THIS DATA BY CELL TYPES 1615 01:19:16,400 --> 01:19:20,360 TO LINK BETWEEN THEM TO DO A 1616 01:19:20,360 --> 01:19:23,800 DEEP PROFILING AND DEEP LOOK AT 1617 01:19:23,800 --> 01:19:26,200 THE INDIVIDUAL CELL TYPES AND 1618 01:19:26,200 --> 01:19:27,680 INVESTIGATE THEIR 1619 01:19:27,680 --> 01:19:28,920 CHARACTERISTICS AS WELL AS TO 1620 01:19:28,920 --> 01:19:31,440 MAP DATA USING THE TOOL TO MAP 1621 01:19:31,440 --> 01:19:34,200 THEIR OWN DATA TO THE CELL TYPES 1622 01:19:34,200 --> 01:19:36,440 TO SEE FOR EXAMPLE WHAT TYPES 1623 01:19:36,440 --> 01:19:37,920 THEIR DATA MIGHT BE 1624 01:19:37,920 --> 01:19:38,960 REPRESENTATIVE OF. 1625 01:19:38,960 --> 01:19:41,560 WE CAN SEE THIS ALIGNMENT. 1626 01:19:41,560 --> 01:19:46,200 NOT ALL CELL TYPES -- THERE ARE 1627 01:19:46,200 --> 01:19:48,920 SPECIFICS TO THE MARMOSET, HUMAN 1628 01:19:48,920 --> 01:19:53,160 AND THE MOUSE BUT THERE IS A 1629 01:19:53,160 --> 01:19:55,280 COMMON CORSET WHICH ALIGNS 1630 01:19:55,280 --> 01:19:56,800 BETWEEN THEM AND WE'RE ABLE TO 1631 01:19:56,800 --> 01:19:59,400 BRING THAT OUT. 1632 01:19:59,400 --> 01:20:03,240 IN THIS CELL TECHNOLOGY EXPLORER 1633 01:20:03,240 --> 01:20:06,320 IT'S A FIRST OF ITS KIND THING. 1634 01:20:06,320 --> 01:20:09,400 IT WAS MOTIVATED BY THIS OPEN 1635 01:20:09,400 --> 01:20:11,160 RESOURCE CALLED GENE CARDS WHICH 1636 01:20:11,160 --> 01:20:12,960 I AM'S SURE MANY PEOPLE ARE 1637 01:20:12,960 --> 01:20:14,920 FAMILIAR WITH. 1638 01:20:14,920 --> 01:20:20,320 BUT HERE WE ACTUALLY INCORPORATE 1639 01:20:20,320 --> 01:20:24,720 THESE MODAL TEASE AND LINKAGES. 1640 01:20:24,720 --> 01:20:29,680 AND IT COMES WITH AN ONTOLOGY 1641 01:20:29,680 --> 01:20:30,680 WHICH EXPLAINS. 1642 01:20:30,680 --> 01:20:33,640 AND USERS CAN CROSS CORRELATE 1643 01:20:33,640 --> 01:20:38,040 AND STUDY THE INDIVIDUAL TYPES. 1644 01:20:38,040 --> 01:20:40,480 I WANT TO TALK ABOUT HOW THIS 1645 01:20:40,480 --> 01:20:43,680 SITS IN THE BIGGER SORT OF OUR 1646 01:20:43,680 --> 01:20:48,400 BIGGER DATA ECOSYSTEM AND ITS 1647 01:20:48,400 --> 01:20:49,400 IMPLICATIONS. 1648 01:20:49,400 --> 01:20:52,200 THESE HAVE REVOLUTIONIZED BOTH 1649 01:20:52,200 --> 01:20:54,440 BASIC SCIENCE IN TERMS OF BEING 1650 01:20:54,440 --> 01:20:56,240 ABLE TO DEVELOP THESE 1651 01:20:56,240 --> 01:20:58,040 CLASSIFICATIONS AS WELL AS NEW 1652 01:20:58,040 --> 01:21:00,800 TOOLS FOR SELECTIVE MANIPULATION 1653 01:21:00,800 --> 01:21:03,040 OF THESE TYPES THROUGH VIRAL AND 1654 01:21:03,040 --> 01:21:05,880 OTHER TYPES OF TECHNOLOGIES BUT 1655 01:21:05,880 --> 01:21:09,200 ALSO HAS VERY PROFOUND DISEASE 1656 01:21:09,200 --> 01:21:12,520 APPLICATIONS IN TERMS OF 1657 01:21:12,520 --> 01:21:18,160 CHARACTERIZING PATHOLOGICAL CELL 1658 01:21:18,160 --> 01:21:20,400 TYPE STATES AND TARGET TOOLS. 1659 01:21:20,400 --> 01:21:24,200 IN A STUDY THAT WE JUST 1660 01:21:24,200 --> 01:21:27,000 PUBLISHED THIS PAST WEEK WE 1661 01:21:27,000 --> 01:21:29,200 COMPARED A CONVENTION, 1662 01:21:29,200 --> 01:21:31,440 CLASSIFICATION OF DISEASES FROM 1663 01:21:31,440 --> 01:21:35,160 THE INTERNATIONAL HEALTH METRIC 1664 01:21:35,160 --> 01:21:36,680 ORGANIZATION, A SEATTLE BASED 1665 01:21:36,680 --> 01:21:40,800 ORGANIZATION WHICH IS A GLOBAL 1666 01:21:40,800 --> 01:21:44,680 CHARACTERIZING OF THE RISK 1667 01:21:44,680 --> 01:21:45,120 PROFILING. 1668 01:21:45,120 --> 01:21:48,880 AND COMPARING IT IN A CELL TYPE 1669 01:21:48,880 --> 01:21:49,360 WAY. 1670 01:21:49,360 --> 01:21:53,840 THIS IS A SET OF 24 RAIN 1671 01:21:53,840 --> 01:21:55,600 DISEASES WHICH ARE HAVING ABOVE 1672 01:21:55,600 --> 01:21:57,960 AVERAGE OF CONCENTRATION OF GENE 1673 01:21:57,960 --> 01:21:59,600 EXPRESSION IN THE CORTEX AND 1674 01:21:59,600 --> 01:22:01,960 VIEWING THEIR DISEASE RISK GENES 1675 01:22:01,960 --> 01:22:04,280 ACROSS THESE DIFFERENT CELL 1676 01:22:04,280 --> 01:22:07,480 TYPES AND WE CAN SEE THERE IS 1677 01:22:07,480 --> 01:22:10,000 INHERENT GRADIENTS WHICH ARE 1678 01:22:10,000 --> 01:22:11,680 REPRODUCIBLE AND EXPLAINABLE. 1679 01:22:11,680 --> 01:22:14,120 AND THE WAY THIS PLAYS INTO THIS 1680 01:22:14,120 --> 01:22:15,720 KNOWLEDGE TYPE EXPLORER IS THAT 1681 01:22:15,720 --> 01:22:21,880 WE CAN USE THESE ALIGNMENTS AND 1682 01:22:21,880 --> 01:22:26,560 LOOKING AT THESE CROSS CONSENSUS 1683 01:22:26,560 --> 01:22:28,200 TAXONOMIES TO LEVERAGE THESE 1684 01:22:28,200 --> 01:22:28,960 THINGS. 1685 01:22:28,960 --> 01:22:31,000 IN PARTICULAR HERE I'M USING 1686 01:22:31,000 --> 01:22:32,920 THIS MAPPING BETWEEN MOUSE AND 1687 01:22:32,920 --> 01:22:36,040 HUMAN TO COMPARE A DISEASE 1688 01:22:36,040 --> 01:22:37,920 SIGNATURE AND HOW THEY COMPARE 1689 01:22:37,920 --> 01:22:40,560 BETWEEN MOUSE AND HUMAN. 1690 01:22:40,560 --> 01:22:42,680 IN THIS MIDDLE PLOT WE'RE 1691 01:22:42,680 --> 01:22:46,280 LOOKING AT A TYPE OF CELL TYPE 1692 01:22:46,280 --> 01:22:47,480 ENRICHMENT 1693 01:22:47,480 --> 01:22:50,360 IS THE CELL TYPE ENRICHED FOR 1694 01:22:50,360 --> 01:22:52,920 EXPRESSION IN ANY KIND OF 1695 01:22:52,920 --> 01:22:53,840 CONCENTRATION. 1696 01:22:53,840 --> 01:22:55,800 AND THE ORANGE REPRESENTS MOUSE 1697 01:22:55,800 --> 01:22:57,800 FOR THE DISEASE AND THE BLUE IS 1698 01:22:57,800 --> 01:23:00,360 THE SAME DISEASE IN HUMAN AND WE 1699 01:23:00,360 --> 01:23:02,800 CAN SEE THERE IS A REMARKABLE 1700 01:23:02,800 --> 01:23:05,000 KIND OF PAIRING OF THESE THAT 1701 01:23:05,000 --> 01:23:05,920 MOUSE AND HUMAN. 1702 01:23:05,920 --> 01:23:08,240 THIS IS JUST A DATA DRIVEN 1703 01:23:08,240 --> 01:23:10,040 PRESENTATION BUT MOUSE AND HUMAN 1704 01:23:10,040 --> 01:23:12,040 ARE ALL KIND OF CLUSTERING 1705 01:23:12,040 --> 01:23:13,920 TOGETHER FOR A LOT OF THESE 1706 01:23:13,920 --> 01:23:15,560 DISEASES INDICATING THAT IT'S 1707 01:23:15,560 --> 01:23:18,320 THE SAME CELL TYPES INVOLVED IN 1708 01:23:18,320 --> 01:23:20,080 THESE DISEASES. 1709 01:23:20,080 --> 01:23:21,040 WHEREAS ON THE RIGHT WHEN WE 1710 01:23:21,040 --> 01:23:27,160 LOOK AT THE EXPRESS LEVEL WE SEE 1711 01:23:27,160 --> 01:23:31,040 A SPECIES SPECIAL GROUPING AND 1712 01:23:31,040 --> 01:23:33,720 THIS IS INDICATIVE OF DIFFERENT 1713 01:23:33,720 --> 01:23:42,080 GREEDIFFER --DIFFERENT GENES IN. 1714 01:23:42,080 --> 01:23:46,240 ANOTHER IS THIS PROJECT CALLED 1715 01:23:46,240 --> 01:23:47,600 SEATTLE ALZHEIMER'S DISEASE 1716 01:23:47,600 --> 01:23:48,360 BRAIN ANALYSIS. 1717 01:23:48,360 --> 01:23:50,880 THIS IS A PARTNERSHIP WITH THE 1718 01:23:50,880 --> 01:23:55,640 UNIVERSITY OF WASHINGTON AND 1719 01:23:55,640 --> 01:23:58,920 KAISER PERMANENTE -- THAT HAVE 1720 01:23:58,920 --> 01:24:02,560 COME IN THROUGH THE SYSTEM WHO 1721 01:24:02,560 --> 01:24:06,160 HAVE DEVELOPED AN ALZHEIMER'S 1722 01:24:06,160 --> 01:24:08,680 DISEASE WHERE WE HAVE EXTENSIVE 1723 01:24:08,680 --> 01:24:11,800 METADATA AND DO A GENOMIC 1724 01:24:11,800 --> 01:24:12,960 PROFILING OF. 1725 01:24:12,960 --> 01:24:16,160 AND SO THIS DATA HAS BEEN 1726 01:24:16,160 --> 01:24:16,760 RELEASED. 1727 01:24:16,760 --> 01:24:19,440 IT LINKS BACK TO THE EXPLORER. 1728 01:24:19,440 --> 01:24:20,720 IT COMES WITH THE ABILITY TO 1729 01:24:20,720 --> 01:24:24,040 LOOK AT THE DATA BY CELL TYPE. 1730 01:24:24,040 --> 01:24:26,560 TO LOOK AT THE NEURO PATHOLOGY 1731 01:24:26,560 --> 01:24:27,040 IMAGES. 1732 01:24:27,040 --> 01:24:30,880 THERE IS A WAY OF LOOKING AT 1733 01:24:30,880 --> 01:24:33,440 INDIVIDUAL DONORS WITH DISEASE 1734 01:24:33,440 --> 01:24:36,840 SEVERITY AND COGNITIVE STATUS BY 1735 01:24:36,840 --> 01:24:40,840 CELL TYPE AND PROJECTING THAT ON 1736 01:24:40,840 --> 01:24:44,560 TO THE NORMAL STATUS OF 1737 01:24:44,560 --> 01:24:46,800 TOXONOMY. 1738 01:24:46,800 --> 01:24:50,600 ONE CAN VIEW THE NEURAL 1739 01:24:50,600 --> 01:24:54,200 PATHOLOGY AND NOW MAP DATE TABAK 1740 01:24:54,200 --> 01:24:59,160 TO THE TAXONOMY SUCH AS IS DONE 1741 01:24:59,160 --> 01:25:06,040 IN THE EXMORER. 1742 01:25:06,040 --> 01:25:06,560 EXPLORER. 1743 01:25:06,560 --> 01:25:10,120 THE IMPORTANCE * IS ONE OF 1744 01:25:10,120 --> 01:25:12,760 COMBINING DATA FROM MULTIPLE 1745 01:25:12,760 --> 01:25:15,840 SOURCES AT A CONSORTIUM LEVEL 1746 01:25:15,840 --> 01:25:18,320 INTO BUILDING TOOLS THAT PROVIDE 1747 01:25:18,320 --> 01:25:20,640 KNOWLEDGE STRUCTURES FOR REALLY 1748 01:25:20,640 --> 01:25:21,280 LEVERAGING INFORMATION. 1749 01:25:21,280 --> 01:25:24,400 YOU KNOW I THINK THE DATA 1750 01:25:24,400 --> 01:25:25,920 SCIENCE SUFFERS IN MANY WAYS 1751 01:25:25,920 --> 01:25:27,400 FROM A LOT OF CHARACTERISTICS 1752 01:25:27,400 --> 01:25:29,160 WHICH I'M SURE EVERYBODY ON 1753 01:25:29,160 --> 01:25:31,920 THESE PANELS HAVE A COMMON KIND 1754 01:25:31,920 --> 01:25:34,240 OF EXPERIENCES. 1755 01:25:34,240 --> 01:25:36,320 WE -- OUR EXPERIENCE OF 1756 01:25:36,320 --> 01:25:39,880 KNOWLEDGE CAPTURE IS TO SOME 1757 01:25:39,880 --> 01:25:50,440 EXTEEX-- EXTENT PubMed. 1758 01:25:51,520 --> 01:25:54,400 AND I THINK THERE ARE MANY 1759 01:25:54,400 --> 01:25:56,880 INITIATIVE US UNDERWAY TO TRY TO 1760 01:25:56,880 --> 01:25:59,240 MAKE SOME PROGRESS THERE. 1761 01:25:59,240 --> 01:26:01,240 SO, THAT IS ALL I WANT TO SAY. 1762 01:26:01,240 --> 01:26:04,440 I WANT TO THANK OUR TEAMMATES 1763 01:26:04,440 --> 01:26:07,400 AND COLLABORATORS ACROSS THE 1764 01:26:07,400 --> 01:26:07,840 CONSORTIUM. 1765 01:26:07,840 --> 01:26:11,320 THANK YOU. 1766 01:26:11,320 --> 01:26:12,720 >>THANK YOU, MICHAEL. 1767 01:26:12,720 --> 01:26:13,720 THAT WAS TERRIFIC. 1768 01:26:13,720 --> 01:26:19,920 AND WE HAVE NOW HEARD FROM OUR 1769 01:26:19,920 --> 01:26:24,600 TWO PANELISTS FOR THIS SESSION. 1770 01:26:24,600 --> 01:26:25,200 DATA REUSE. 1771 01:26:25,200 --> 01:26:30,640 AND PARTICULARLY DATA REUSE IN 1772 01:26:30,640 --> 01:26:33,200 ADVANCING HUMAN HEALTH. 1773 01:26:33,200 --> 01:26:37,640 SO I WOULD LIKE TO NOW OPEN UP 1774 01:26:37,640 --> 01:26:39,840 TO QUESTIONS. 1775 01:26:39,840 --> 01:26:42,600 I WOULD ENCOURAGE ANYONE TO ASK 1776 01:26:42,600 --> 01:26:44,120 QUESTIONS ON SLIDO. 1777 01:26:44,120 --> 01:26:49,360 GO TO SLIDO.com AND ENTER 1379 1778 01:26:49,360 --> 01:26:51,240 AND THAT WILL GIVE THE QUESTIONS 1779 01:26:51,240 --> 01:26:52,240 TO THIS SESSION. 1780 01:26:52,240 --> 01:26:54,760 I'M GOING TO START WITH A 1781 01:26:54,760 --> 01:26:56,840 QUESTION ACTUALLY FROM THE 1782 01:26:56,840 --> 01:26:58,800 AUDIENCE TO OMAR. 1783 01:26:58,800 --> 01:27:02,560 FROM YOUR OUTREACH TO ENCOURAGE 1784 01:27:02,560 --> 01:27:04,480 DATABASE USAGE WHAT ARE SOME OF 1785 01:27:04,480 --> 01:27:06,920 THE WAYS THAT YOU HAVE BEEN ABLE 1786 01:27:06,920 --> 01:27:09,480 TO GENERATE ENGAGEMENT AROUND 1787 01:27:09,480 --> 01:27:12,480 YOUR WORK TO THE COMMUNITY? 1788 01:27:12,480 --> 01:27:15,960 >>THAT IS A GOOD QUESTION. 1789 01:27:15,960 --> 01:27:18,480 OBVIOUSLY A PROCESS. 1790 01:27:18,480 --> 01:27:20,320 OUTREACH IS A PROCESS. 1791 01:27:20,320 --> 01:27:23,880 YOU DON'T JUST SHOW UP AND DO 1792 01:27:23,880 --> 01:27:25,520 ONE THING. 1793 01:27:25,520 --> 01:27:29,000 IT'S A PROCESS. 1794 01:27:29,000 --> 01:27:30,600 IT INVOLVES ENSURING THAT THE 1795 01:27:30,600 --> 01:27:32,640 COMMUNITY FEELS AS A PARTNER. 1796 01:27:32,640 --> 01:27:37,680 I CANNOT STRESS THAT TOO MUCH. 1797 01:27:37,680 --> 01:27:39,320 AND ANY CONFERENCE WE ATTEND. 1798 01:27:39,320 --> 01:27:41,440 ANY WORKSHOP THAT WE RUN. 1799 01:27:41,440 --> 01:27:44,560 ANY WEBINAR WE PERFORM WE 1800 01:27:44,560 --> 01:27:46,160 CONDUCT OUR GOAL ALWAYS IS TO 1801 01:27:46,160 --> 01:27:47,680 MAKE SURE THE COMMUNITY IS AWARE 1802 01:27:47,680 --> 01:27:49,360 THAT THEY CAN GIVE US FEEDBACK 1803 01:27:49,360 --> 01:27:51,760 AND TELL US WHAT THEY NEED. 1804 01:27:51,760 --> 01:27:55,840 WHEN WE BUILD -- THE RESOURCES 1805 01:27:55,840 --> 01:27:58,520 OUR GOAL WAS NOT TO BUILD TOOLS 1806 01:27:58,520 --> 01:27:59,600 FOR OURSELVES. 1807 01:27:59,600 --> 01:28:02,760 I'M NOT DOING RESEARCH. 1808 01:28:02,760 --> 01:28:05,080 WHAT I'M TRYING TO MAKE SURE IS 1809 01:28:05,080 --> 01:28:07,360 THAT THE TOOLS THAT WE'RE 1810 01:28:07,360 --> 01:28:08,640 BUILDING ARE USE. 1811 01:28:08,640 --> 01:28:12,400 TO THE USERS SO THEY CAN DO THE 1812 01:28:12,400 --> 01:28:16,280 RESEARCH. 1813 01:28:16,280 --> 01:28:19,160 ANY TIME WE'RE AT CONFERENCES WE 1814 01:28:19,160 --> 01:28:22,480 MAKE SURE WE HAVE HELP DESK. 1815 01:28:22,480 --> 01:28:26,240 DESIGNED TO BE AND TO PROVIDE 1816 01:28:26,240 --> 01:28:26,920 TUTORIALS. 1817 01:28:26,920 --> 01:28:28,640 MAKE US VERY ACCESSIBLE. 1818 01:28:28,640 --> 01:28:30,960 WE HAVE A VERY ACTIVE HELP LINE 1819 01:28:30,960 --> 01:28:31,760 ON-LINE. 1820 01:28:31,760 --> 01:28:34,800 SO WE GET I THINK CLOSE TO 20 1821 01:28:34,800 --> 01:28:36,920 E-MAILS A WEEK ASKING US 1822 01:28:36,920 --> 01:28:38,960 ANYTHING FROM HOW CAN WE ANALYZE 1823 01:28:38,960 --> 01:28:41,160 A CERTAIN DATASET TO TELL US 1824 01:28:41,160 --> 01:28:43,880 ABOUT NEW DATA AND NEW 1825 01:28:43,880 --> 01:28:45,080 FUNCTIONS. 1826 01:28:45,080 --> 01:28:46,840 OR LET US KNOW ABOUT A BUG ON 1827 01:28:46,840 --> 01:28:49,480 THE SITE WHICH IS GREAT TOO. 1828 01:28:49,480 --> 01:28:51,960 A LOT OF COMMUNITY ENGAGEMENT. 1829 01:28:51,960 --> 01:28:53,760 WE'RE VERY ACTIVE ON SOCIAL 1830 01:28:53,760 --> 01:28:55,160 MEDIA. 1831 01:28:55,160 --> 01:28:56,920 FACEBOOK AND Twitter. 1832 01:28:56,920 --> 01:29:01,560 WE DO TWEET OUT ALL THE TIME 1833 01:29:01,560 --> 01:29:04,000 MAKING SHARE THAT WE'RE PART OF 1834 01:29:04,000 --> 01:29:06,080 THE 13 HEAR OF SCIENTISTS. 1835 01:29:06,080 --> 01:29:10,720 * OPEN ACCESS AND MAKING SURE 1836 01:29:10,720 --> 01:29:12,520 THAT WE'RE ACCESSIBLE TO 1837 01:29:12,520 --> 01:29:14,880 EVERYBODY. 1838 01:29:14,880 --> 01:29:16,800 >>THAT IS A TERRIFIC ANSWER TO 1839 01:29:16,800 --> 01:29:19,600 A VERY GOOD QUESTION BECAUSE YOU 1840 01:29:19,600 --> 01:29:21,240 REALLY EMPHASIZE THE IMPORTANCE 1841 01:29:21,240 --> 01:29:24,520 OF DEVELOPING A RESOURCE THAT IS 1842 01:29:24,520 --> 01:29:26,080 SHARED BY THE COMMUNITY. 1843 01:29:26,080 --> 01:29:29,320 SO THERE IS CERTAINLY A SENSE A 1844 01:29:29,320 --> 01:29:30,760 OWNERSHIP AND PEOPLE OF WANT TO 1845 01:29:30,760 --> 01:29:32,080 CONTRIBUTE AND MAKE IT BETTER. 1846 01:29:32,080 --> 01:29:37,760 SO I THINK THAT IS REALLY HUGE. 1847 01:29:37,760 --> 01:29:39,960 MICHAEL FROM YOUR PERSPECTIVE, 1848 01:29:39,960 --> 01:29:45,040 YOU ALSO HAVE A COMMUNITY THAT 1849 01:29:45,040 --> 01:29:47,120 IS CONTRIBUTING. 1850 01:29:47,120 --> 01:29:50,360 HOW DO YOU ALSO SHARE THAT 1851 01:29:50,360 --> 01:29:52,600 KNOWLEDGE WITH YOUR COMMUNITY? 1852 01:29:52,600 --> 01:29:57,280 WITH THE NEURO COMMUNITY? 1853 01:29:57,280 --> 01:30:02,040 >>I GUESS FOR ONE THING LARGE 1854 01:30:02,040 --> 01:30:05,480 SCALE NEURO SITES INITIATIVES 1855 01:30:05,480 --> 01:30:07,720 HAVE BECOME INCREASINGLY 1856 01:30:07,720 --> 01:30:09,560 COLLABORATIVE. 1857 01:30:09,560 --> 01:30:10,960 THERE IS MORE ORGANIZATION. 1858 01:30:10,960 --> 01:30:12,440 OUR PROGRAM OFFICERS ARE MUCH 1859 01:30:12,440 --> 01:30:13,200 MORE INVOLVED. 1860 01:30:13,200 --> 01:30:17,280 WE HAVE A LOT OF -- THERE IS A 1861 01:30:17,280 --> 01:30:19,600 LOT OF JOINT WORK AND WORKING 1862 01:30:19,600 --> 01:30:21,480 GROUPS AND STANDARDS BOARDS AND 1863 01:30:21,480 --> 01:30:24,360 OTHER THINGS FOR PUTTING 1864 01:30:24,360 --> 01:30:25,240 INFORMATION FORWARD WHICH TRIES 1865 01:30:25,240 --> 01:30:27,040 TO CAPTURE THIS AND PRESENT THIS 1866 01:30:27,040 --> 01:30:29,560 IN A WAY. 1867 01:30:29,560 --> 01:30:31,480 FURTHER AS A MANDATE OF THE 1868 01:30:31,480 --> 01:30:33,080 BRAIN INITIATIVE ALL OF THAT 1869 01:30:33,080 --> 01:30:35,920 DATA GOES INTO PUBLIC ARCHIVES 1870 01:30:35,920 --> 01:30:38,800 WHICH ARE MAINTAINED AND ARE 1871 01:30:38,800 --> 01:30:41,360 ACTIVELY INVOLVED IN THIS DATA 1872 01:30:41,360 --> 01:30:43,240 STANDARDIZATION EFFORT. 1873 01:30:43,240 --> 01:30:47,280 SO, ITS STILL IN PERFECT AND I 1874 01:30:47,280 --> 01:30:50,480 DON'T KNOW THAT * WE ADDRESS 1875 01:30:50,480 --> 01:30:51,920 USER'S INTEREST AND CONCERNS AS 1876 01:30:51,920 --> 01:30:54,760 WELL AS WE STILL COULD. 1877 01:30:54,760 --> 01:30:57,880 BUT THAT IS BASICALLY IT. 1878 01:30:57,880 --> 01:31:00,560 >>YEAH AND I WOULD ALSO SAY 1879 01:31:00,560 --> 01:31:03,760 THAT YOU'RE STARTING MORE 1880 01:31:03,760 --> 01:31:07,160 RECENTLY THAN OMAR AND THE 1881 01:31:07,160 --> 01:31:09,240 DATABASE. 1882 01:31:09,240 --> 01:31:14,160 SO YOU'VE GOT ROOM TO GROW IN 1883 01:31:14,160 --> 01:31:14,640 THAT AREA. 1884 01:31:14,640 --> 01:31:17,960 BUT TRULY WE'RE IN AN ERA OF 1885 01:31:17,960 --> 01:31:19,840 EMBRACING TEAM SCIENCE AND 1886 01:31:19,840 --> 01:31:20,840 COLLABORATION. 1887 01:31:20,840 --> 01:31:24,040 AND I THINK BOTH OF YOU HAVE 1888 01:31:24,040 --> 01:31:26,800 GIVEN SOME EXCELLENT EXAMPLES OF 1889 01:31:26,800 --> 01:31:30,120 HOW THAT IS MANIFESTED. 1890 01:31:30,120 --> 01:31:34,840 SO MICHAEL, I'M SORRY OMAR, THE 1891 01:31:34,840 --> 01:31:35,760 QUESTION CAME IN SPECIFICALLY 1892 01:31:35,760 --> 01:31:40,800 FOR YOU IN TERMS OF HAVE YOU 1893 01:31:40,800 --> 01:31:42,840 ENSURED THE QUALITY 1894 01:31:42,840 --> 01:31:47,360 DATA AND WHAT IS THE DATA -- 1895 01:31:47,360 --> 01:31:48,560 ROLE IN THIS? 1896 01:31:48,560 --> 01:31:51,200 >>THAT IS A GOOD QUESTION AS 1897 01:31:51,200 --> 01:31:52,120 WELL. 1898 01:31:52,120 --> 01:31:55,000 ANY TIME YOU REANALYZE 1899 01:31:55,000 --> 01:31:58,160 SOMEBODY'S DATA THERE IS A WORRY 1900 01:31:58,160 --> 01:31:59,920 -- THAT YOU DO SOMETHING WRONG 1901 01:31:59,920 --> 01:32:02,360 AND YOU MISS ANALYZE THE DATA 1902 01:32:02,360 --> 01:32:04,800 AND NOW YOU'RE SHOWING ANALYSIS 1903 01:32:04,800 --> 01:32:07,560 THAT IS WRONG AND THAT IS 1904 01:32:07,560 --> 01:32:09,000 MISLEADING. 1905 01:32:09,000 --> 01:32:11,240 YOU MAY DO SOMETHING RIGHT BUT 1906 01:32:11,240 --> 01:32:12,960 IT TURNS OUT THAT YOUR ANALYSIS 1907 01:32:12,960 --> 01:32:14,640 BASED ON THE NEW TOOLS THAT 1908 01:32:14,640 --> 01:32:17,640 YOU'RE USING OR UPDATED TOOLS IS 1909 01:32:17,640 --> 01:32:20,600 PROVIDING DIFFERENT RESULTS. 1910 01:32:20,600 --> 01:32:22,560 AND DIFFERENT RESULTS CAN BE 1911 01:32:22,560 --> 01:32:25,160 DIFFERENT LAYERS. 1912 01:32:25,160 --> 01:32:27,080 WHICH ARE COMPLETELY OPPOSITE TO 1913 01:32:27,080 --> 01:32:29,120 WHAT THE SCIENTIST FOUND 1914 01:32:29,120 --> 01:32:31,840 INITIALLY AND THAT COULD HAPPEN. 1915 01:32:31,840 --> 01:32:34,720 OR IN MOST CASES THERE IS SOME 1916 01:32:34,720 --> 01:32:38,120 SLIGHT DIFFERENCES AND THAT IS 1917 01:32:38,120 --> 01:32:38,600 FINE. 1918 01:32:38,600 --> 01:32:42,640 THAT IS WHAT SCIENCE IS ABOUT. 1919 01:32:42,640 --> 01:32:44,480 GENE EXPRESSIONS THAT ARE 1920 01:32:44,480 --> 01:32:46,480 QUESTIONABLE AND ONE ANALYSIS 1921 01:32:46,480 --> 01:32:47,640 THAT TURNED OUT TO BE 1922 01:32:47,640 --> 01:32:48,160 SIGNIFICANT. 1923 01:32:48,160 --> 01:32:50,080 THE IDEA IS TO PROVIDE THE 1924 01:32:50,080 --> 01:32:52,080 USESSERS WITH THE ABILITY TO GO 1925 01:32:52,080 --> 01:32:55,080 IN AND TWEAK THE KNOBS AND 1926 01:32:55,080 --> 01:32:56,360 CHANGE THE PARAMETERS. 1927 01:32:56,360 --> 01:33:00,680 I WANT TO BE MORE RESTRICTIVE OR 1928 01:33:00,680 --> 01:33:02,000 LESS RESTRICTIVE. 1929 01:33:02,000 --> 01:33:05,760 IN ORDER FOR US TO QUALITY 1930 01:33:05,760 --> 01:33:07,640 ASSURE THIS WE DO A COUPLE OF 1931 01:33:07,640 --> 01:33:08,080 THINGS. 1932 01:33:08,080 --> 01:33:11,720 WE HAVE AUTOMATED QUALITY 1933 01:33:11,720 --> 01:33:14,480 ASSURANCE SCRIPTS THAT RUN AND 1934 01:33:14,480 --> 01:33:16,480 MAKE SURE THAT THE DATA IS 1935 01:33:16,480 --> 01:33:20,200 LOADED UP CORRECTLY. 1936 01:33:20,200 --> 01:33:22,880 AND SO RESULTS ARE SHOWING UP 1937 01:33:22,880 --> 01:33:24,720 AND WE'RE GETTING NUMBERS. 1938 01:33:24,720 --> 01:33:27,040 THEN WE HAVE A SECOND LAYER 1939 01:33:27,040 --> 01:33:29,360 WHICH INVOLVES THE OUTREACH TEAM 1940 01:33:29,360 --> 01:33:30,640 WHERE THEY LOOKING AT THE DATA 1941 01:33:30,640 --> 01:33:32,120 IN THE DATABASE. 1942 01:33:32,120 --> 01:33:34,360 THEY RUN A SEARCH AND SEE WHAT 1943 01:33:34,360 --> 01:33:36,800 KIND OF RESULTS AND COMPARE THAT 1944 01:33:36,800 --> 01:33:40,200 TO WHAT WAS DESCRIBED IN THE 1945 01:33:40,200 --> 01:33:40,800 PAPER. 1946 01:33:40,800 --> 01:33:44,720 DOES THAT MAKE SENSE? 1947 01:33:44,720 --> 01:33:47,640 ARE WE GETTING WEIRD THINGS? 1948 01:33:47,640 --> 01:33:48,840 SO THAT HELPS US. 1949 01:33:48,840 --> 01:33:51,040 THAT IS OUR FIRST LAYER AND 1950 01:33:51,040 --> 01:33:56,120 AFTER THAT WE SEND AN E-MAIL TO 1951 01:33:56,120 --> 01:33:59,880 THE SCIENTIST. 1952 01:33:59,880 --> 01:34:02,120 WE SEND EVERY PERSON AN E-MAIL 1953 01:34:02,120 --> 01:34:03,960 AND LET THEM KNOW THAT YOUR DATA 1954 01:34:03,960 --> 01:34:05,560 IS AVAILABLE AND GIVE THEM 1955 01:34:05,560 --> 01:34:09,080 ACCESS TO A PASSWORD PROTECTED 1956 01:34:09,080 --> 01:34:13,400 SIDE FOR A COUPLE OF WEEKS 1957 01:34:13,400 --> 01:34:14,800 BEFORE IT IS RELEASED. 1958 01:34:14,800 --> 01:34:17,640 *. 1959 01:34:17,640 --> 01:34:18,720 IT'S STREAMLINED. 1960 01:34:18,720 --> 01:34:22,280 AND FROM THAT NOT ONLY DO WE GET 1961 01:34:22,280 --> 01:34:25,400 FEEDBACK FROM OUR PROVIDERS THE 1962 01:34:25,400 --> 01:34:27,360 SCIENTISTS BUT ALSO BUILDS 1963 01:34:27,360 --> 01:34:27,840 TRUST. 1964 01:34:27,840 --> 01:34:29,680 AND THAT IS THE FEEDBACK LOOP. 1965 01:34:29,680 --> 01:34:31,880 7 THEY ARE EXCITED TO COME AND 1966 01:34:31,880 --> 01:34:35,960 TALK TO US AND GIVING US DATA. 1967 01:34:35,960 --> 01:34:39,280 WE GET A HUGE AMOUNT OF DATA 1968 01:34:39,280 --> 01:34:40,760 PREPUBLICATION AND WE HAVE A 1969 01:34:40,760 --> 01:34:43,960 STRICT POLICY OF NEVER RELEASING 1970 01:34:43,960 --> 01:34:45,960 ANY DATA UNTIL THE PROVIDE ERA 1971 01:34:45,960 --> 01:34:47,040 PROVES. 1972 01:34:47,040 --> 01:34:51,360 AND AS A RESULT WE HAVE A UNIQUE 1973 01:34:51,360 --> 01:34:53,120 POSITION WHERE WE CAN SHOW DATA 1974 01:34:53,120 --> 01:34:55,080 PROVIDERS THEIR DATA BEFORE IT 1975 01:34:55,080 --> 01:34:59,400 IS PUBLISHED AND THEY SAY THIS 1976 01:34:59,400 --> 01:35:00,040 IS GREAT. 1977 01:35:00,040 --> 01:35:01,880 LET'S RELEASE IT. 1978 01:35:01,880 --> 01:35:03,640 MY DATA IS ALREADY ON THE 1979 01:35:03,640 --> 01:35:04,520 BIOARCHIVE. 1980 01:35:04,520 --> 01:35:07,080 THEY CAN NOW SEARCH IT AND THE 1981 01:35:07,080 --> 01:35:08,520 REVIEWERS CAN GO AND PLAY AROUND 1982 01:35:08,520 --> 01:35:10,640 WITH THE DATA AS THEY ARE 1983 01:35:10,640 --> 01:35:11,760 REVIEWING THE PAPER. 1984 01:35:11,760 --> 01:35:13,320 SO THAT HAS BEEN A HUGE 1985 01:35:13,320 --> 01:35:14,600 ADVANTAGE OF BUILDING THIS 1986 01:35:14,600 --> 01:35:16,440 COMMUNITY TRUST. 1987 01:35:16,440 --> 01:35:16,720 >>WOW! 1988 01:35:16,720 --> 01:35:18,080 THAT IS HUGE. 1989 01:35:18,080 --> 01:35:20,160 BECAUSE THAT SPEAKS TO THE POWER 1990 01:35:20,160 --> 01:35:23,520 OF THE DATA AND IT SPEAKS TO 1991 01:35:23,520 --> 01:35:26,960 WHAT WE'RE TRYING TO BUILD HERE. 1992 01:35:26,960 --> 01:35:31,040 IN TERMS OF NIH AND FASEB AND 1993 01:35:31,040 --> 01:35:34,320 BEING ABLE TO SHARE THE DATA. 1994 01:35:34,320 --> 01:35:36,200 THANK YOU FOR SHARING THAT. 1995 01:35:36,200 --> 01:35:38,200 IT ALSO SPEAKS TO PEOPLE 1996 01:35:38,200 --> 01:35:39,760 RECOGNIZING YOUR COMMUNITY, 1997 01:35:39,760 --> 01:35:42,560 RECOGNIZING THE VALUE OF BEING 1998 01:35:42,560 --> 01:35:43,280 PART OF THIS. 1999 01:35:43,280 --> 01:35:45,960 IT'S BIGGER THAN ANY ONE OF US 2000 01:35:45,960 --> 01:35:48,720 AND THAT IS A GREAT THING. 2001 01:35:48,720 --> 01:35:52,640 SO, THANK YOU. 2002 01:35:52,640 --> 01:35:58,480 IN TERMS OF MICHAEL IN TERMS OF 2003 01:35:58,480 --> 01:36:00,280 -- ARE THERE ANY FINANCIAL 2004 01:36:00,280 --> 01:36:01,840 REQUIREMENTS IN TERMS OF 2005 01:36:01,840 --> 01:36:04,000 ACCESSING THE DATABASE? 2006 01:36:04,000 --> 01:36:06,440 THE CELL TYPE DATABASE? 2007 01:36:06,440 --> 01:36:09,160 >>NO. 2008 01:36:09,160 --> 01:36:10,040 EVERYTHING IS OPEN AND 2009 01:36:10,040 --> 01:36:17,560 AVAILABLE. 2010 01:36:17,560 --> 01:36:20,000 I WANT TO RAISE ANOTHER POINT IF 2011 01:36:20,000 --> 01:36:22,280 I MIGHT. 2012 01:36:22,280 --> 01:36:24,200 >>SURE 2013 01:36:24,200 --> 01:36:25,880 >>PART OF THE PLIGHT OF DATA 2014 01:36:25,880 --> 01:36:28,400 USE IN BIOLOGY AND NEURO 2015 01:36:28,400 --> 01:36:30,280 SCIENCES AND BIOLOGY IN GENERAL 2016 01:36:30,280 --> 01:36:33,280 IS THAT WE DON'T NECESSARILY 2017 01:36:33,280 --> 01:36:36,040 REALLY EFFECTIVELY USE THE DATA 2018 01:36:36,040 --> 01:36:37,040 THAT WE HAVE COLLECTED. 2019 01:36:37,040 --> 01:36:42,520 RIGHT. 2020 01:36:42,520 --> 01:36:45,920 IT'S AS IF OUR FEAR OF A LACK OF 2021 01:36:45,920 --> 01:36:47,160 UNDERSTANDING OF THE MECHANISMS 2022 01:36:47,160 --> 01:36:50,480 AND THE SYSTEMS WE'RE EXPLORING, 2023 01:36:50,480 --> 01:36:53,240 IT'S ALMOST AS IF WE ASSUME THAT 2024 01:36:53,240 --> 01:36:55,440 WE DON'T KNOW ANYTHING AND IT'S 2025 01:36:55,440 --> 01:36:56,800 REQUIRED TO START AGAIN WITH A 2026 01:36:56,800 --> 01:36:59,800 NEW TECHNOLOGY AND NEW DATASET. 2027 01:36:59,800 --> 01:37:01,800 AND NEW TECHNOLOGY IS GREAT. 2028 01:37:01,800 --> 01:37:05,000 THEY ALLOW PEOPLE TO EXPLORE 2029 01:37:05,000 --> 01:37:07,440 DEEPER AND MORE PRECISELY. 2030 01:37:07,440 --> 01:37:12,720 8 BUT PART -- OF THE DATA 2031 01:37:12,720 --> 01:37:13,960 ENGINEERING AND KNOWLEDGE 2032 01:37:13,960 --> 01:37:16,120 SUFFERS BECAUSE IT ENDS UP BEING 2033 01:37:16,120 --> 01:37:19,320 LARGELY A KIND OF REPOSITORY OF 2034 01:37:19,320 --> 01:37:21,440 DATA THAT IS NOT EFFECTIVELY 2035 01:37:21,440 --> 01:37:21,920 USED. 2036 01:37:21,920 --> 01:37:24,480 NOT LEVERAGED AND NEW 2037 01:37:24,480 --> 01:37:26,360 EXPERIMENTS ARE PROPOSED ALL THE 2038 01:37:26,360 --> 01:37:26,800 TIME. 2039 01:37:26,800 --> 01:37:28,720 ONE OF THE BIGGEST CHALLENGES 2040 01:37:28,720 --> 01:37:31,920 THAT WE CAN TAKE ON IS ATTEMPT 2041 01:37:31,920 --> 01:37:33,720 TO STRESS THE VALUE OR HIGHLIGHT 2042 01:37:33,720 --> 01:37:36,840 THE VALUE OF EXISTING DATA AND 2043 01:37:36,840 --> 01:37:41,840 USE THAT IN LEVERAGING OUR 2044 01:37:41,840 --> 01:37:43,440 SCIENTIFIC HYPOTHESIS. 2045 01:37:43,440 --> 01:37:45,560 >>I COMPLETELY AGREE AND I'M 2046 01:37:45,560 --> 01:37:47,640 SURE THAT MANY OF THE AUDIENCE 2047 01:37:47,640 --> 01:37:49,560 WOULD AGREE AS WELL. 2048 01:37:49,560 --> 01:37:51,120 IT ALSO GETS TO THE POINT THAT 2049 01:37:51,120 --> 01:37:54,280 BOTH OF YOU SPOKE TO WHICH IS 2050 01:37:54,280 --> 01:37:58,560 THE IMPORTANT OF ONTOLOGY 2051 01:37:58,560 --> 01:38:01,840 WHETHER THIS IS EXHIBITING. 2052 01:38:01,840 --> 01:38:05,360 -- EXISTING AND DEVELOPING. 2053 01:38:05,360 --> 01:38:06,800 PEOPLE UNDERSTAND ESTIMATE THE 2054 01:38:06,800 --> 01:38:08,600 IMPORTANCE OF ONTOLOGY IN TERMS 2055 01:38:08,600 --> 01:38:11,480 OF TRULY SHARING THE DATA AND 2056 01:38:11,480 --> 01:38:16,320 SPEAKS TO THE IMPORTANCE OF THE 2057 01:38:16,320 --> 01:38:17,680 METADATA 2058 01:38:17,680 --> 01:38:22,560 >>THE INFRASTRUCTURE -- 2059 01:38:22,560 --> 01:38:26,120 ALTHOUGH IT'S NOT PAID FOR AND 2060 01:38:26,120 --> 01:38:29,120 IT'S NOT PRIORITIZED ONE COULD 2061 01:38:29,120 --> 01:38:31,200 IMAGINE A FAR BETTER KNOWLEDGE 2062 01:38:31,200 --> 01:38:32,560 ORGANIZATION OF WHAT WE KNOW 2063 01:38:32,560 --> 01:38:36,880 WITH RESPECT TO OUR DATA THAN 2064 01:38:36,880 --> 01:38:37,440 EXIST TODAY. 2065 01:38:37,440 --> 01:38:39,920 YOU GO TO PubMed AND SEE IF 2066 01:38:39,920 --> 01:38:43,520 THERE IS A SUPPLEMENTARY DATASET 2067 01:38:43,520 --> 01:38:44,840 THAT IS REQUIRED. 2068 01:38:44,840 --> 01:38:47,040 BUT THAT IS A FAR CRY FROM BEING 2069 01:38:47,040 --> 01:38:49,160 ABLE TO USE AND UNDERSTAND THIS 2070 01:38:49,160 --> 01:38:51,520 DATA IN ANY REAL CONTEXT. 2071 01:38:51,520 --> 01:38:53,720 >>ABSOLUTELY. 2072 01:38:53,720 --> 01:38:59,320 SO MICHAEL, ONE OF THE QUESTIONS 2073 01:38:59,320 --> 01:39:05,040 WITH REGARDS TO COMPARISONS THAT 2074 01:39:05,040 --> 01:39:07,680 YOU SHOWED BETWEEN NELSON AND 2075 01:39:07,680 --> 01:39:09,920 HUMAN -- IS THIS SOMETHING THAT 2076 01:39:09,920 --> 01:39:12,440 YOU SEE THAT IS GOING TO BE VERY 2077 01:39:12,440 --> 01:39:14,160 IMPORTANT IN TERMS OF GOING 2078 01:39:14,160 --> 01:39:17,240 FORWARD WITH SOME OF THE ANIMAL 2079 01:39:17,240 --> 01:39:20,320 MODELS DEVELOPED FOR DISEASE? 2080 01:39:20,320 --> 01:39:21,640 >>ANOTHER STEPPING-STONE AT 2081 01:39:21,640 --> 01:39:23,560 LEAST IN OUR ABILITY TO 2082 01:39:23,560 --> 01:39:26,200 UNDERSTAND WHAT IS DIFFERENT AND 2083 01:39:26,200 --> 01:39:28,520 WHAT WORKS AND WHAT DOESN'T WORK 2084 01:39:28,520 --> 01:39:30,320 WITH RESPECT TO THE DISEASE 2085 01:39:30,320 --> 01:39:33,720 MODELS IN MODEL ORGANISMS. 2086 01:39:33,720 --> 01:39:35,240 RIGHT. 2087 01:39:35,240 --> 01:39:37,960 WE ALWAYS HEAR COMPLAINTS IN 2088 01:39:37,960 --> 01:39:39,920 TERMS OF THE FAILURE OF MODELS 2089 01:39:39,920 --> 01:39:44,120 AND ALZHEIMER'S, PSYCHIATRIC 2090 01:39:44,120 --> 01:39:46,280 DISEASES AND THINGS LIKE THAT. 2091 01:39:46,280 --> 01:39:48,280 BUT I THINK THE WAY TO ADDRESS 2092 01:39:48,280 --> 01:39:49,960 THAT IS TO UNDERSTAND AND DETAIL 2093 01:39:49,960 --> 01:39:51,480 SOME OF THE REGULATORY 2094 01:39:51,480 --> 01:39:53,400 DIFFERENCE ESPECIALLY IN THE WAY 2095 01:39:53,400 --> 01:39:57,680 GENES INTERACT AND ARE EXPRESSED 2096 01:39:57,680 --> 01:39:59,560 AT A CELL TYPE LEVEL. 2097 01:39:59,560 --> 01:40:02,640 THAT IS VERY IMPORTANT. 2098 01:40:02,640 --> 01:40:04,040 IT'S QUITE REMARKABLE. 2099 01:40:04,040 --> 01:40:06,600 NOW WE HAVE REALLY A WHOLE KIND 2100 01:40:06,600 --> 01:40:10,960 OF REALLY -- A MAJOR KIND OF 2101 01:40:10,960 --> 01:40:12,560 TAXONOMY ACROSS SPECIES. 2102 01:40:12,560 --> 01:40:18,480 MANY SPECIES FROM GREAT APES AND 2103 01:40:18,480 --> 01:40:21,480 OTHER MAMMALS AND WE SEE COMMON 2104 01:40:21,480 --> 01:40:24,640 STRUCTURE AND PATTERNS AND VERY 2105 01:40:24,640 --> 01:40:26,640 SPECIES DIFFERENCES THAT CAN BE 2106 01:40:26,640 --> 01:40:27,120 LEVERAGED. 2107 01:40:27,120 --> 01:40:29,880 THIS IS A REALLY IMPORTANT 2108 01:40:29,880 --> 01:40:32,320 DIRECTION PROBABLY FOR DECIDING 2109 01:40:32,320 --> 01:40:35,680 AND UNDERSTANDING UNIQUE HUMAN 2110 01:40:35,680 --> 01:40:36,520 ISSUES. 2111 01:40:36,520 --> 01:40:36,960 >>YEAH. 2112 01:40:36,960 --> 01:40:39,120 THANK YOU. 2113 01:40:39,120 --> 01:40:41,000 ANOTHER QUESTION INTERESTING 2114 01:40:41,000 --> 01:40:42,640 POINT AROUND KNOWLEDGE CAPTURE. 2115 01:40:42,640 --> 01:40:44,400 WHERE DO YOU SEE THIS MOVING 2116 01:40:44,400 --> 01:40:46,200 FORWARD AND WHAT INFRASTRUCTURE 2117 01:40:46,200 --> 01:40:49,280 IS MOST IMPACTFUL IN 2118 01:40:49,280 --> 01:40:51,040 ACCELERATING KNOWLEDGE CAPTURE. 2119 01:40:51,040 --> 01:41:01,240 DO ONE OF YOU WANT TO TAKE THAT? 2120 01:41:01,240 --> 01:41:04,400 >>SO I THINK OBVIOUSLY HAVING A 2121 01:41:04,400 --> 01:41:10,080 MECHANISM TO CAPTURE THE 2122 01:41:10,080 --> 01:41:11,200 COMMUNITY'S KNOWLEDGE THE 2123 01:41:11,200 --> 01:41:13,920 SCIENTISTS THAT ARE USING THESE 2124 01:41:13,920 --> 01:41:15,320 RESOURCES. 2125 01:41:15,320 --> 01:41:18,800 IT IS ALSO A FREE RESOURCE. 2126 01:41:18,800 --> 01:41:23,440 HAVING A WAY TO BUILD ON WHAT WE 2127 01:41:23,440 --> 01:41:25,760 CAPTURED FROM PUBLICATIONS OR 2128 01:41:25,760 --> 01:41:27,840 FROM THE DATA ITSELF IS SUPER 2129 01:41:27,840 --> 01:41:29,560 IMPORTANT AND WE'VE DEVELOPED A 2130 01:41:29,560 --> 01:41:31,080 FEW WAYS OF DOING THAT. 2131 01:41:31,080 --> 01:41:34,480 YOU HAVE TO ALSO THINK ABOUT THE 2132 01:41:34,480 --> 01:41:37,680 THRESHOLD THE ENTRY THRESHOLD OF 2133 01:41:37,680 --> 01:41:39,240 ANY OF THESE MECHANISMS. 2134 01:41:39,240 --> 01:41:41,080 ONE THING THAT WE PUT TOGETHER 2135 01:41:41,080 --> 01:41:45,080 WAS A USER COMMENT SYSTEM WHICH 2136 01:41:45,080 --> 01:41:47,080 ALLOWS ANYBODY TO LOG IN AND PUT 2137 01:41:47,080 --> 01:41:52,160 A COMMENT ON A GENE PAGE. 2138 01:41:52,160 --> 01:41:54,720 AND THE COOL THING IS THAT NOW 2139 01:41:54,720 --> 01:41:56,600 WE HAVE PEOPLE ON A REGULAR 2140 01:41:56,600 --> 01:41:59,000 BASES WHO GO IN AND ENTER 2141 01:41:59,000 --> 01:42:00,800 COMMENTS ON GENES. 2142 01:42:00,800 --> 01:42:04,800 EITHER SOMETHING PUBLISHED OR 2143 01:42:04,800 --> 01:42:06,560 SOMETHING THAT THEY HAVE 2144 01:42:06,560 --> 01:42:07,920 DISCOVERED THEMSELVES IN THE LAB 2145 01:42:07,920 --> 01:42:10,720 BUT NEVER PUBLISHED. 2146 01:42:10,720 --> 01:42:13,640 OR IT'S NOT PUBLISHABLE 2147 01:42:13,640 --> 01:42:15,080 INFORMATION BUT STILL USEFUL 2148 01:42:15,080 --> 01:42:18,920 INFORMATION AND WE HAVE OVER 2149 01:42:18,920 --> 01:42:21,040 40,000 USER COMMENTS IN THE 2150 01:42:21,040 --> 01:42:21,840 DATABASE. 2151 01:42:21,840 --> 01:42:23,720 SO THERE ARE 40,000 COMMENTS 2152 01:42:23,720 --> 01:42:25,360 FROM INDIVIDUALS WHO OVER THE 2153 01:42:25,360 --> 01:42:27,360 YEARS WHO HAVE ENTERED COMMENTS. 2154 01:42:27,360 --> 01:42:30,680 AND MANY OF THEM ARE VERY USEFUL 2155 01:42:30,680 --> 01:42:32,000 WHICH TELLS YOU SOMETHING ABOUT 2156 01:42:32,000 --> 01:42:33,640 A GENE THAT WAS NOT KNOWN 2157 01:42:33,640 --> 01:42:34,120 BEFORE. 2158 01:42:34,120 --> 01:42:37,760 WE HAVE SOME MORE SOPHISTICATED 2159 01:42:37,760 --> 01:42:38,280 WAYS. 2160 01:42:38,280 --> 01:42:40,080 FOR EXAMPLE -- NOT ONLY THE 2161 01:42:40,080 --> 01:42:45,080 GENOMES THAT WE HAVE IN OUR 2162 01:42:45,080 --> 01:42:50,000 DATABASES -- GENE STRUCTURE AND 2163 01:42:50,000 --> 01:42:56,240 ALTERNATIVE PLEASE VARIANTS. 2164 01:42:56,240 --> 01:43:03,200 WE HAVE INTEGRATED A TOOL CALLED 2165 01:43:03,200 --> 01:43:05,960 APOLLO THAT ALLOWS THE USESSER 2166 01:43:05,960 --> 01:43:08,600 TO GO IN AND STRUCTURE A GENE 2167 01:43:08,600 --> 01:43:10,040 MODEL AND CONTRIBUTE IT BACK AND 2168 01:43:10,040 --> 01:43:13,400 NOW WE MAKE THAT BACK THAT IS 2169 01:43:13,400 --> 01:43:15,760 AVAILABLE FOR ANYBODY TO QUERY 2170 01:43:15,760 --> 01:43:18,720 AND ANALYZE. 2171 01:43:18,720 --> 01:43:21,680 THOSE ARE A COUPLE OF METHODS OF 2172 01:43:21,680 --> 01:43:23,920 HOW WE PROVIDE WAYS OF CAPTURING 2173 01:43:23,920 --> 01:43:25,000 COMMUNITY KNOWLEDGE. 2174 01:43:25,000 --> 01:43:28,440 WE'RE WORKING ON EXCITING WAYS 2175 01:43:28,440 --> 01:43:30,760 THAT WILL ALLOW USERS TO UPLOAD 2176 01:43:30,760 --> 01:43:33,080 AND ANALYZE THEIR OWN DATA. 2177 01:43:33,080 --> 01:43:36,080 AND THEN TO ALLOW USERS TO FLIP 2178 01:43:36,080 --> 01:43:37,440 THE SWITCH AND MAKE IT AVAILABLE 2179 01:43:37,440 --> 01:43:38,280 TO THE COMMUNITY. 2180 01:43:38,280 --> 01:43:43,600 ANOTHER WAY TO CAPTURE USER 2181 01:43:43,600 --> 01:43:47,560 ANALYSIS THAT CAN BE INTEGRATED 2182 01:43:47,560 --> 01:43:51,200 SO PEOPLE CAN RUN EXPERIMENTS 2183 01:43:51,200 --> 01:43:54,080 USING INTEGRATED DATA. 2184 01:43:54,080 --> 01:43:56,800 >>MICHAEL, DID YOU WANT TO ADD 2185 01:43:56,800 --> 01:43:58,480 ANYTHING FROM THIS ASPECT FROM 2186 01:43:58,480 --> 01:44:02,200 YOUR STUDIES. 2187 01:44:02,200 --> 01:44:03,680 >>WELL HE COVERS IT PRETTY 2188 01:44:03,680 --> 01:44:08,440 WELL. 2189 01:44:08,440 --> 01:44:12,800 JUST, TO ME I'M VERY INTERESTED 2190 01:44:12,800 --> 01:44:15,320 IN THE IDEA THAT THE CAPTURING 2191 01:44:15,320 --> 01:44:17,720 OF KNOWLEDGE AND WHAT WE KNOW. 2192 01:44:17,720 --> 01:44:20,840 AND AN ATTEMPT TO -- BECAUSE THE 2193 01:44:20,840 --> 01:44:22,840 TREMENDOUS INEFFICIENCY IN THE 2194 01:44:22,840 --> 01:44:25,320 SCIENTIFIC PROCESS. 2195 01:44:25,320 --> 01:44:27,000 IT'S REALLY VERY, VERY 2196 01:44:27,000 --> 01:44:27,560 INEFFICIENT. 2197 01:44:27,560 --> 01:44:30,440 7 AND I THINK THAT IF 2198 01:44:30,440 --> 01:44:33,680 INFORMATION AND KNOWLEDGE WERE 2199 01:44:33,680 --> 01:44:35,760 STRUCTURED BETTER, YOU CAN'T BE 2200 01:44:35,760 --> 01:44:39,760 MAYBE KIND OF REALLY TOO 2201 01:44:39,760 --> 01:44:41,760 AMBITIOUS BUT YOU CAN KNOWLEDGE 2202 01:44:41,760 --> 01:44:43,960 PICK A DOMAIN OF KNOWLEDGE THAT 2203 01:44:43,960 --> 01:44:47,480 YOU WORK IN AND IF THERE WAS A 2204 01:44:47,480 --> 01:44:48,960 CENTRALIZED STATE OF WHAT WAS 2205 01:44:48,960 --> 01:44:51,200 NONAND WHAT DATA CONTRIBUTED TO 2206 01:44:51,200 --> 01:44:54,160 THAT AND IF THERE WAS SOMETHING 2207 01:44:54,160 --> 01:45:00,640 THAT IS NEW THAT YOU CAN MAP IT. 2208 01:45:00,640 --> 01:45:03,280 THE EFFICIENCY TO MOVE FORWARD 2209 01:45:03,280 --> 01:45:05,000 WOULD BE SO MUCH GREATER. 2210 01:45:05,000 --> 01:45:06,800 I DON'T KNOW WHEN WE'LL GET 2211 01:45:06,800 --> 01:45:08,320 THERE. 2212 01:45:08,320 --> 01:45:09,400 BUT YEAH. 2213 01:45:09,400 --> 01:45:12,200 THAT IS THE ASPIRATION. 2214 01:45:12,200 --> 01:45:13,560 >>THAT IS DEFINITELY THE 2215 01:45:13,560 --> 01:45:15,760 ASPIRATION. 2216 01:45:15,760 --> 01:45:18,480 AND AS WE ALL KNOW IS THAT 2217 01:45:18,480 --> 01:45:22,200 SCIENCE IS NOT STATIC. 2218 01:45:22,200 --> 01:45:24,360 SO SIMILAR TO THE QUESTION TO 2219 01:45:24,360 --> 01:45:26,360 THE LAST PANEL WHAT ARE THE 2220 01:45:26,360 --> 01:45:33,400 PROSPECTS FOR USING AI TO 2221 01:45:33,400 --> 01:45:36,520 FACILITATE QUERIES IDENTIFYING 2222 01:45:36,520 --> 01:45:39,920 GENES AND CELLS OF INTEREST. 2223 01:45:39,920 --> 01:45:42,040 MICHAEL, THAT IS A QUESTION FOR 2224 01:45:42,040 --> 01:45:42,400 YOU 2225 01:45:42,400 --> 01:45:43,080 >>I DON'T KNOW. 2226 01:45:43,080 --> 01:45:47,720 WE THINK OF AI AS DIFFERENT 2227 01:45:47,720 --> 01:45:49,920 THINGS. 2228 01:45:49,920 --> 01:45:51,480 RECAPITULATION OF STUFF THAT WE 2229 01:45:51,480 --> 01:45:52,240 KNOW ALREADY AND THE 2230 01:45:52,240 --> 01:45:54,160 PRESENTATION OF IT AND POSSIBLY 2231 01:45:54,160 --> 01:45:57,400 CONNECTION OF INSIGHTS WHICH ARE 2232 01:45:57,400 --> 01:45:59,920 ACTUALLY REFERRING TO CONNECTING 2233 01:45:59,920 --> 01:46:01,600 THINGS IN DATABASE STRUCTURE 2234 01:46:01,600 --> 01:46:03,560 THAT WE UNDERSTAND. 2235 01:46:03,560 --> 01:46:04,720 BUT THERE IS ANOTHER LEVEL THAT 2236 01:46:04,720 --> 01:46:07,960 WE APPLY IT BEFORE THAT WHICH IS 2237 01:46:07,960 --> 01:46:09,640 TYPICALLY ADVANCED MACHINE 2238 01:46:09,640 --> 01:46:12,520 LEARNING TO TEASE OUT 2239 01:46:12,520 --> 01:46:14,120 SIGNIFICANCE IN DATA AND 2240 01:46:14,120 --> 01:46:15,520 ASSOCIATIONS AND THAT STILL HAS 2241 01:46:15,520 --> 01:46:17,000 A LONG WAY TO GO. 2242 01:46:17,000 --> 01:46:19,240 FOR EXAMPLE, JUST UNDERSTANDING 2243 01:46:19,240 --> 01:46:21,800 GENE REGULATORY MECHANISMS AND 2244 01:46:21,800 --> 01:46:25,800 THE MAPPING OF THE EPIGENETIC 2245 01:46:25,800 --> 01:46:30,120 DATA AND ITS SIGNIFICANCE IS A 2246 01:46:30,120 --> 01:46:34,880 MAJOR INITIATIVE. 2247 01:46:34,880 --> 01:46:38,680 AND I THINK THAT I PREFER TO SEE 2248 01:46:38,680 --> 01:46:41,440 THE APPLICATION OF THESE MACHINE 2249 01:46:41,440 --> 01:46:43,360 LEARNING TECHNOLOGIES THERE IN 2250 01:46:43,360 --> 01:46:45,800 TERMS OF TRYING TO REALLY DEEPLY 2251 01:46:45,800 --> 01:46:47,720 TEASE OUT WHAT WE CAN LEARN 2252 01:46:47,720 --> 01:46:52,320 RATHER THAN APPLYING THEM AT AN 2253 01:46:52,320 --> 01:46:54,440 ORGANIZATIONAL RECAPITULATION 2254 01:46:54,440 --> 01:46:54,640 LEVEL. 2255 01:46:54,640 --> 01:46:56,440 THERE IS STILL SO MUCH WORK TO 2256 01:46:56,440 --> 01:46:57,840 DO THERE. 2257 01:46:57,840 --> 01:47:01,520 I THINK WE'RE ALWAYS DAUNTED BY 2258 01:47:01,520 --> 01:47:06,120 THE COME -- COMPLEXITY OF THE S. 2259 01:47:06,120 --> 01:47:15,320 WE DON'T REALLY UNDERSTAND 2260 01:47:15,320 --> 01:47:16,400 C-ELEGANS. 2261 01:47:16,400 --> 01:47:17,960 AND THAT SAYS SOMETHING ABOUT 2262 01:47:17,960 --> 01:47:20,360 OUR ABILITY TO UNDERSTAND THE 2263 01:47:20,360 --> 01:47:21,760 HUMAN BRAIN. 2264 01:47:21,760 --> 01:47:23,160 >>WELL PUT. 2265 01:47:23,160 --> 01:47:24,560 OMAR. 2266 01:47:24,560 --> 01:47:25,920 >>DEFINITELY. 2267 01:47:25,920 --> 01:47:29,960 I SHOWED THAT SEARCH STRATEGY. 2268 01:47:29,960 --> 01:47:32,040 THAT CHOO-CHOO TRAIN THAT IS 2269 01:47:32,040 --> 01:47:33,040 INTEGRATED TOGETHER. 2270 01:47:33,040 --> 01:47:36,880 WE VIEW THAT AS A POOR PERSON'S 2271 01:47:36,880 --> 01:47:38,320 CHAT GPT. 2272 01:47:38,320 --> 01:47:40,760 WHAT I'VE DONE WITH ONE OF THESE 2273 01:47:40,760 --> 01:47:45,400 STRATEGIES IS THAT THEY ASK 2274 01:47:45,400 --> 01:47:46,400 MULTIPLE QUESTIONS AND PROVIDING 2275 01:47:46,400 --> 01:47:47,480 THE STRUCTURE TO IT. 2276 01:47:47,480 --> 01:47:49,880 WHAT WE WOULD LIKE TO DO AND 2277 01:47:49,880 --> 01:47:53,280 THAT IS OBVIOUSLY PART OF OUR 2278 01:47:53,280 --> 01:47:54,920 NEXT ITERATION. 2279 01:47:54,920 --> 01:47:59,200 TO USE NATURAL LANGUAGE SOFTWARE 2280 01:47:59,200 --> 01:48:01,880 TO COME IN AND SAY WELL I WANT 2281 01:48:01,880 --> 01:48:05,400 TO FIND ALL OF THE GENES THAT 2282 01:48:05,400 --> 01:48:07,960 MIGHT BE EXAMPLE PRESSESSED IN 2283 01:48:07,960 --> 01:48:12,240 THE -- STAGES -- AND BY THE WAY 2284 01:48:12,240 --> 01:48:16,880 MAKE SURE THAT THEY ALSO HAVE 2285 01:48:16,880 --> 01:48:18,120 EVIDENCE FROM AT LEAST FIVE 2286 01:48:18,120 --> 01:48:18,920 STUDIES. 2287 01:48:18,920 --> 01:48:23,360 7 BASICALLY WE CAN CODIFY THAT 2288 01:48:23,360 --> 01:48:25,000 STRATEGY INTO INQUIRIES AND AS 2289 01:48:25,000 --> 01:48:29,120 LONG AS WE CAN LINK THAT BETWEEN 2290 01:48:29,120 --> 01:48:32,520 NATIONAL LANGUAGE DECIPHERING 2291 01:48:32,520 --> 01:48:34,960 MECHANISMS THEN WE MAY BE IN A 2292 01:48:34,960 --> 01:48:36,840 PLACE FOR USERS TO TYPE A 2293 01:48:36,840 --> 01:48:38,880 QUESTION LIKE THAT. 2294 01:48:38,880 --> 01:48:42,600 THERE IS MORE DATA THAT WE HAVE 2295 01:48:42,600 --> 01:48:44,440 AND WE CAN ALSO START APPLYING 2296 01:48:44,440 --> 01:48:47,520 MACHINE LEARNING METHODS TO FIND 2297 01:48:47,520 --> 01:48:51,280 CONNECTIONS AND THREADS SO WE 2298 01:48:51,280 --> 01:48:54,080 HAVE VARIOUS TYPES OF DATA TYPES 2299 01:48:54,080 --> 01:48:55,600 BUT WE NEED MORE AND THE MORE 2300 01:48:55,600 --> 01:48:58,720 THAT WE GET THE MORE WE CAN FEED 2301 01:48:58,720 --> 01:49:01,040 THESE MACHINE LEARNING 2302 01:49:01,040 --> 01:49:04,360 ALGORITHMS TO COME UP WITH 2303 01:49:04,360 --> 01:49:04,960 INFORMATIVE RESULTS 2304 01:49:04,960 --> 01:49:07,160 >>THAT IS A VERY GOOD POINT 2305 01:49:07,160 --> 01:49:11,360 BECAUSE THE DIFFERENT DATA THE 2306 01:49:11,360 --> 01:49:13,200 DIFFERENCES IS QUITE DIFFERENT. 2307 01:49:13,200 --> 01:49:18,520 AND MICHAEL TOUCHED ON THE -- 2308 01:49:18,520 --> 01:49:21,080 TRANS DOME AND THERE ARE SO MANY 2309 01:49:21,080 --> 01:49:23,080 THINGS THAT WE NEED TO EMBARK 2310 01:49:23,080 --> 01:49:23,640 ON. 2311 01:49:23,640 --> 01:49:25,840 BUT I'M GLAD THAT YOU'RE BOTH 2312 01:49:25,840 --> 01:49:28,480 THINKING ABOUT THAT. 2313 01:49:28,480 --> 01:49:29,760 THERE WAS A QUESTION. 2314 01:49:29,760 --> 01:49:32,480 IS THERE SUPPORT FOR LINKING THE 2315 01:49:32,480 --> 01:49:34,680 GENOMIC DATA TO RELATED CLINICAL 2316 01:49:34,680 --> 01:49:37,320 DATA. 2317 01:49:37,320 --> 01:49:40,800 THAT IS A LOADED QUESTION. 2318 01:49:40,800 --> 01:49:46,440 >>NOT IN OUR CASE YET. 2319 01:49:46,440 --> 01:49:48,200 EXCEPT AS I INDICATED THROUGH 2320 01:49:48,200 --> 01:49:50,760 MAPPING THROUGH THE SAME 2321 01:49:50,760 --> 01:49:52,440 TAXONOMY AND ITS ORGANIZATION. 2322 01:49:52,440 --> 01:49:55,440 FOR EXAMPLE OUR ALZHEIMER'S 2323 01:49:55,440 --> 01:49:57,440 DATABASE WHICH YOU CAN LINK AND 2324 01:49:57,440 --> 01:50:00,480 MAP BACK TO THE SAME CELL TYPES. 2325 01:50:00,480 --> 01:50:02,120 IN THAT SENSE YES. 2326 01:50:02,120 --> 01:50:03,960 BUT IN THE GENERAL SENSE OF 2327 01:50:03,960 --> 01:50:06,920 LINKING OUT TO LARGER COMMUNITY 2328 01:50:06,920 --> 01:50:10,800 DATASETS IN ALZHEIMER'S DISEASE 2329 01:50:10,800 --> 01:50:11,240 NO. 2330 01:50:11,240 --> 01:50:13,360 NOT YET. 2331 01:50:13,360 --> 01:50:14,960 THE DATA IS AVAILABLE. 2332 01:50:14,960 --> 01:50:17,000 PEOPLE CAN DO IT. 2333 01:50:17,000 --> 01:50:19,320 BUT IT'S NOT IN A USER-FRIENDLY 2334 01:50:19,320 --> 01:50:25,480 WAY. 2335 01:50:25,480 --> 01:50:28,480 >>SO WE HAVE MECHANISM IN PLACE 2336 01:50:28,480 --> 01:50:30,600 WHERE WE CAN LOAD CLINICAL 2337 01:50:30,600 --> 01:50:31,120 INFORMATION. 2338 01:50:31,120 --> 01:50:34,680 SO METADATA -- ABOUT THE 2339 01:50:34,680 --> 01:50:36,440 INDIVIDUALS THAT THE SAMPLES 2340 01:50:36,440 --> 01:50:38,800 CAME FROM AND FOR EXAMPLE IF YOU 2341 01:50:38,800 --> 01:50:41,960 HAVE INDIVIDUALS WHOSE MALARIA 2342 01:50:41,960 --> 01:50:44,960 ISOLETTES WERE SEQUENCED WE HAVE 2343 01:50:44,960 --> 01:50:48,640 WAYS OF CAPTURING THAT AND 2344 01:50:48,640 --> 01:50:52,320 MAKING THOSE INQUIRIES. 2345 01:50:52,320 --> 01:50:53,760 AN IMPORTANT POINT. 2346 01:50:53,760 --> 01:50:57,520 THERE ARE A LOT OF LARGE STUDIES 2347 01:50:57,520 --> 01:51:01,680 OUT THERE THAT ARE RICH WITH 2348 01:51:01,680 --> 01:51:03,360 DATA. THEY INCLUDE A LOT OF 2349 01:51:03,360 --> 01:51:05,680 DATA AND YOU WANT TO BE ABLE TO 2350 01:51:05,680 --> 01:51:07,000 CORRELATE AND INTEGRATE AND THEN 2351 01:51:07,000 --> 01:51:10,560 LOOK AT THE GENOME SEQUENCES OR 2352 01:51:10,560 --> 01:51:12,120 REQUEST SAMPLES. 2353 01:51:12,120 --> 01:51:14,280 AND I WOULD LIKE TO GIVE A SHOUT 2354 01:51:14,280 --> 01:51:16,040 OUT TO ANOTHER PROJECT THAT PART 2355 01:51:16,040 --> 01:51:19,720 OF OUR GROUP THAT WORKS ON THE 2356 01:51:19,720 --> 01:51:30,240 BRC FUNDED, IT'S CALLED KLIN -- 2357 01:51:33,040 --> 01:51:35,280 F PB. 2358 01:51:35,280 --> 01:51:39,600 TO MAKE THE DATA AVAILABLE IN A 2359 01:51:39,600 --> 01:51:41,880 WAY WHERE EVERYBODY CAN CARY IT 2360 01:51:41,880 --> 01:51:42,800 AND ACCESS IT. 2361 01:51:42,800 --> 01:51:44,960 THAT IS A PRETTY COOL STUDY. 2362 01:51:44,960 --> 01:51:48,120 A HUGE AMOUNT OF POTENTIAL. 2363 01:51:48,120 --> 01:51:50,760 BUT WE NEED SOME VISIONARY 2364 01:51:50,760 --> 01:51:53,680 FUNDERS TO SAY THAT THIS 2365 01:51:53,680 --> 01:51:55,760 REQUIRES SOME TEETH BEHIND IT TO 2366 01:51:55,760 --> 01:51:57,800 MAKE SURE THAT IT'S SUSTAINABLE 2367 01:51:57,800 --> 01:51:59,760 AND WORKS. 2368 01:51:59,760 --> 01:52:02,280 THAT IS EXCITING AND I HOPE THAT 2369 01:52:02,280 --> 01:52:03,880 WILL PROGRESS. 2370 01:52:03,880 --> 01:52:06,280 >>THAT IS A GOOD POINT IN TERMS 2371 01:52:06,280 --> 01:52:10,080 OF THE FUNDERS AND THERE WAS A 2372 01:52:10,080 --> 01:52:13,640 QUESTION EARLIER ARE THERE 2373 01:52:13,640 --> 01:52:15,280 SOCIETIES OR ORGANIZED GROUPS 2374 01:52:15,280 --> 01:52:17,600 HELPING TO PROVIDE AWARENESS OF 2375 01:52:17,600 --> 01:52:21,120 YOUR RESOURCES AND IN TERMS OF 2376 01:52:21,120 --> 01:52:22,280 FURTHER DEVELOPMENT AND 2377 01:52:22,280 --> 01:52:26,160 EXPANSION. 2378 01:52:26,160 --> 01:52:29,120 >>I CAN TELL YOU FROM MY 2379 01:52:29,120 --> 01:52:30,920 PERSPECTIVE BECAUSE WE'VE BEEN 2380 01:52:30,920 --> 01:52:32,240 WORKING HANDLED IN HAND WITH THE 2381 01:52:32,240 --> 01:52:33,640 COMMUNITY FOR YEARS. 2382 01:52:33,640 --> 01:52:37,280 IT'S VERY EXCITING TO ATTEND 2383 01:52:37,280 --> 01:52:39,560 CONFERENCES BECAUSE WE OFTEN GET 2384 01:52:39,560 --> 01:52:42,240 INVITED TO COME AND MANY THAT WE 2385 01:52:42,240 --> 01:52:44,280 ATTEND WE'RE REQUESTED TO HAVE A 2386 01:52:44,280 --> 01:52:45,680 BOOTH. 2387 01:52:45,680 --> 01:52:47,840 AND PROVIDE SUPPORT TO OUR 2388 01:52:47,840 --> 01:52:48,480 USERS. 2389 01:52:48,480 --> 01:52:50,600 AND IN MOST CASES WE DON'T EVEN 2390 01:52:50,600 --> 01:52:51,920 HAVE TO PAY FOR THE BOOTH. 2391 01:52:51,920 --> 01:52:53,840 THIS IS A COMMUNITY RESOURCE AND 2392 01:52:53,840 --> 01:52:56,360 WE WANT YOU TO BE THERE. 2393 01:52:56,360 --> 01:52:59,360 YOU'RE SUPPORTING THE COMMUNITY 2394 01:52:59,360 --> 01:53:03,000 AND THAT IS THE WAY IT SHOULD BE 2395 01:53:03,000 --> 01:53:04,120 FOR COMMUNITIES THAT IT'S 2396 01:53:04,120 --> 01:53:05,320 BENEFITING. 2397 01:53:05,320 --> 01:53:07,960 THEY ARE EXCITED ABOUT HAVING 2398 01:53:07,960 --> 01:53:08,120 US. 2399 01:53:08,120 --> 01:53:12,040 OF COURSE, THAT DOES NOT 2400 01:53:12,040 --> 01:53:14,040 NECESSARILY TRANSLATE INTO 2401 01:53:14,040 --> 01:53:16,720 FUNDING US BUT THEY MAKE SURE 2402 01:53:16,720 --> 01:53:19,120 THAT WE'RE ENGAGED WITH THE 2403 01:53:19,120 --> 01:53:20,480 COMMUNITY. 2404 01:53:20,480 --> 01:53:23,920 >>WELL I THINK FROM THIS 2405 01:53:23,920 --> 01:53:26,240 PERSPECTIVE THIS PRIZE THIS 2406 01:53:26,240 --> 01:53:28,520 AWARD IS REALLY IMPORTANT. 2407 01:53:28,520 --> 01:53:31,840 SO I HAVE TO ASK THE QUESTION. 2408 01:53:31,840 --> 01:53:33,160 HOW DID YOU EACH FIND OUT ABOUT 2409 01:53:33,160 --> 01:53:36,520 THE DATA WORKS CHALLENGE? 2410 01:53:36,520 --> 01:53:38,520 OMAR, DO YOU WANT TO GO FIRST? 2411 01:53:38,520 --> 01:53:39,120 >>SURE. 2412 01:53:39,120 --> 01:53:41,760 WE ACTUALLY WERE MADE AWARE BY 2413 01:53:41,760 --> 01:53:46,600 THE CHALLENGE FROM OUR 2414 01:53:46,600 --> 01:53:49,800 CONTRACTING OFFICER, MARIA -- 2415 01:53:49,800 --> 01:53:52,480 SHE IS AT NIAID. 2416 01:53:52,480 --> 01:53:55,480 THIS IS GOING ON IN CASE YOU MAY 2417 01:53:55,480 --> 01:53:56,360 BE INTERESTED. 2418 01:53:56,360 --> 01:53:57,960 IN THE EARLY DAYS WHEN IT WAS 2419 01:53:57,960 --> 01:54:06,360 FIRST ANNOUNCE ENDS -- ANNOUNC. 2420 01:54:06,360 --> 01:54:10,080 EVERYTHING THAT WE'RE DOING FITS 2421 01:54:10,080 --> 01:54:11,800 THE REQUIREMENT AND WE THOUGHT 2422 01:54:11,800 --> 01:54:14,520 WE HAD A GOOD CHANCE AND SUPER 2423 01:54:14,520 --> 01:54:16,640 HAPPY THAT WE'RE AMONG THE 2424 01:54:16,640 --> 01:54:19,240 PEOPLE THAT ARE RECOGNIZED. 2425 01:54:19,240 --> 01:54:20,520 >>A GREAT RECOGNITION. 2426 01:54:20,520 --> 01:54:20,960 DEFINITELY. 2427 01:54:20,960 --> 01:54:21,800 MICHAEL. 2428 01:54:21,800 --> 01:54:25,320 >>I THINK I JUST DISCOVERED IT 2429 01:54:25,320 --> 01:54:27,880 THROUGH SOME OF YOUR PUBLICITY 2430 01:54:27,880 --> 01:54:29,640 AND ADVERTISING. 2431 01:54:29,640 --> 01:54:32,400 AND I CAME UPON IT AND I WAS 2432 01:54:32,400 --> 01:54:34,920 REALLY SO IMPRESSED WITH THE 2433 01:54:34,920 --> 01:54:38,040 IDEA THAT PEOPLE INVOLVED IN 2434 01:54:38,040 --> 01:54:39,960 THIS ACTIVITY WOULD POTENTIALLY 2435 01:54:39,960 --> 01:54:41,760 BE RECOGNIZED IN THIS WAY THAT 2436 01:54:41,760 --> 01:54:44,400 IT WAS SO NOVEL THAT I THOUGHT 2437 01:54:44,400 --> 01:54:47,280 WOW, THIS IS JUST GREAT. 2438 01:54:47,280 --> 01:54:50,840 AND I THOUGHT ABOUT THE ALLEN 2439 01:54:50,840 --> 01:54:56,640 INSTITUTE OF PU PUTTING OUT DATA 2440 01:54:56,640 --> 01:54:58,320 AND MAYBE WE WOULD STAND A 2441 01:54:58,320 --> 01:54:59,880 CHANCE OF DOING SOMETHING THAT 2442 01:54:59,880 --> 01:55:01,200 COULD BE RECOGNIZED THERE. 2443 01:55:01,200 --> 01:55:03,520 SO THAT IS WHY I ORGANIZED OUR 2444 01:55:03,520 --> 01:55:05,920 TEAM AND WE PUT IT FORWARD. 2445 01:55:05,920 --> 01:55:08,480 WE'RE VERY GRATEFUL CERTAINLY TO 2446 01:55:08,480 --> 01:55:13,440 THE NIH AND FASEB FOR 2447 01:55:13,440 --> 01:55:15,160 ESTABLISHING THIS. 2448 01:55:15,160 --> 01:55:17,840 THIS IS A PRESTIGIOUS AND 2449 01:55:17,840 --> 01:55:19,120 REMARKABLE THING 2450 01:55:19,120 --> 01:55:20,320 >>CONGRATULATIONS TO BOTH OF 2451 01:55:20,320 --> 01:55:21,640 YOU AND YOUR TEAMS. 2452 01:55:21,640 --> 01:55:26,240 IT IS TRULY BOTH WONDERFUL 2453 01:55:26,240 --> 01:55:28,480 EXAMPLES ABOUT THE POWER OF TEAM 2454 01:55:28,480 --> 01:55:30,160 SCIENCE AND COLLABORATION AND 2455 01:55:30,160 --> 01:55:31,280 DATA SHARING. 2456 01:55:31,280 --> 01:55:34,120 WHAT WE'RE ALL ABOUT HERE. 2457 01:55:34,120 --> 01:55:36,680 SO THANK YOU TO FASEB AND THANK 2458 01:55:36,680 --> 01:55:38,720 YOU TO NIH BECAUSE IT SOUNDS 2459 01:55:38,720 --> 01:55:40,560 LIKE THERE WILL BE ADDITIONAL 2460 01:55:40,560 --> 01:55:42,680 FUNDING TO CONTINUE THIS. 2461 01:55:42,680 --> 01:55:45,640 WE WANT TO HEAR ABOUT HOW DATA 2462 01:55:45,640 --> 01:55:49,160 SHARING WORKS AND HOW IT CAN 2463 01:55:49,160 --> 01:55:52,160 HELP ADVANCE OTHER RESEARCH. 2464 01:55:52,160 --> 01:55:54,360 I THINK THAT IS IT FOR OUR 2465 01:55:54,360 --> 01:55:56,200 QUESTIONS. 2466 01:55:56,200 --> 01:55:58,000 AND WHAT I WOULD LIKE TO DO IS 2467 01:55:58,000 --> 01:56:01,200 TELL EVERYONE THAT RIGHT NOW WE 2468 01:56:01,200 --> 01:56:03,280 ARE GOING INTO A 15 MINUTE 2469 01:56:03,280 --> 01:56:05,640 BREAK. 2470 01:56:05,640 --> 01:56:09,680 BUT WE WILL CONVENE AGAIN AT 2471 01:56:09,680 --> 01:56:15,120 1:15 WITH TWO ADDITIONAL PANELS 2472 01:56:15,120 --> 01:56:17,240 AND I LOOK FORWARD TO SEEING YOU 2473 01:56:17,240 --> 01:56:20,120 AGAIN AND OMAR AND MICHAEL THANK 2474 01:56:20,120 --> 01:56:21,680 YOU VERY MUCH FOR YOUR 2475 01:56:21,680 --> 01:56:22,360 PRESENTATIONS. 2476 01:56:22,360 --> 01:56:23,960 THIS WAS TERRIFIC. 2477 01:56:23,960 --> 01:56:26,000 >>THANK YOU. 2478 01:56:26,000 --> 01:56:26,760 >>ALL RIGHT. 2479 01:56:26,760 --> 01:56:29,760 SEE EVERYONE AT 1:15 AFTER THE 2480 01:56:29,760 --> 01:56:32,080 BREAK. 2481 01:56:32,080 --> 01:56:33,400 >>WELCOME 2482 01:56:33,400 --> 01:56:38,040 BACK EVERYBODY TO THE DATA WORK 2483 01:56:38,040 --> 01:56:52,040 PRIZE SYMPOSIUM. 2484 01:56:52,040 --> 01:56:53,960 WE'LL HEAR FROM THREE * REALLY 2485 01:56:53,960 --> 01:56:54,920 COOL PROJECTS. 2486 01:56:54,920 --> 01:56:57,240 WE'LL HAVE MONICA MUNOZ-TORRES 2487 01:56:57,240 --> 01:56:59,440 WHO WILL TALK ABOUT THE 2488 01:56:59,440 --> 01:56:59,920 INITIATIVE. 2489 01:56:59,920 --> 01:57:05,280 NEXT WE'LL HAVE THE ANALYSIS 2490 01:57:05,280 --> 01:57:08,960 GROUP AND FINALLY TO CLOSE OUT 2491 01:57:08,960 --> 01:57:11,880 THE PRESENTATION PART WE'LL HEAR 2492 01:57:11,880 --> 01:57:15,120 FROM GIULIO FORMENTI. 2493 01:57:15,120 --> 01:57:16,160 AFTER THE PRESENTATION WE'LL 2494 01:57:16,160 --> 01:57:20,320 HAVE A Q&A SESSION AND WE INVITE 2495 01:57:20,320 --> 01:57:24,800 YOU TO SUBMIT YOUR QUESTIONS ON 2496 01:57:24,800 --> 01:57:26,320 SLIDO. 2497 01:57:26,320 --> 01:57:29,800 EVENT NUMBER 1379. 2498 01:57:29,800 --> 01:57:31,080 MONICA, PLEASE GO AHEAD. 2499 01:57:31,080 --> 01:57:39,680 >>THANK YOU. 2500 01:57:39,680 --> 01:57:41,440 DO YOU HAVE MY SLIDES? 2501 01:57:41,440 --> 01:57:42,760 >>YES. 2502 01:57:42,760 --> 01:57:43,200 >>WONDERFUL. 2503 01:57:43,200 --> 01:57:45,560 IT'S MY PLEASURE TO BE HERE 2504 01:57:45,560 --> 01:57:47,440 TODAY. 2505 01:57:47,440 --> 01:57:50,000 I'M MONICA MUNOZ-TORRES AND THE 2506 01:57:50,000 --> 01:57:51,960 PROGRAM DIRECTOR. 2507 01:57:51,960 --> 01:57:56,520 TODAY I'M GOING TO TAKE TIME TO 2508 01:57:56,520 --> 01:58:00,560 BRIEFLY SHARE ABOUT WHAT AND WHO 2509 01:58:00,560 --> 01:58:02,880 IS THE MONARCH INITIATIVE AND 2510 01:58:02,880 --> 01:58:05,080 SHARE DETAILS ABOUT OUR TEAM AT 2511 01:58:05,080 --> 01:58:10,880 THE END OF THE PRESENTATION. 2512 01:58:10,880 --> 01:58:17,360 THE MONARCH INITIATIVE -- IT WAS 2513 01:58:17,360 --> 01:58:18,640 LAUNCHED IN 2013 AND OUR INITIAL 2514 01:58:18,640 --> 01:58:20,720 GOAL WAS TO LEVERAGE ALL OF THE 2515 01:58:20,720 --> 01:58:23,720 DATA FROM ACROSS ORGANISMS AND 2516 01:58:23,720 --> 01:58:29,440 SOURCES TO IMPROVE RARE DISEASE 2517 01:58:29,440 --> 01:58:38,200 DIAGNDIAGNOSTICS. 2518 01:58:38,200 --> 01:58:41,920 MONARCH RESOURCES ARE NOW 2519 01:58:41,920 --> 01:58:44,240 INTEGRATED AND WE WORK CLOSELY 2520 01:58:44,240 --> 01:58:46,880 WITH A VARIETY OF COMMUNITIES TO 2521 01:58:46,880 --> 01:58:49,280 HELP CENTRALIZE DATA FOR REUSE. 2522 01:58:49,280 --> 01:58:51,400 WE BELIEVE THAT IT'S IMPORTANT 2523 01:58:51,400 --> 01:58:53,960 TO MAXIMIZE THE UTILITY AND 2524 01:58:53,960 --> 01:58:55,080 IMPACT. 2525 01:58:55,080 --> 01:58:57,840 IT IS COMPOSED OF MULTIPLE OPEN 2526 01:58:57,840 --> 01:59:01,240 SOURCE AND OPEN ACCESS. 2527 01:59:01,240 --> 01:59:03,800 WE PROMOTE TRANSPARENT AND NEW 2528 01:59:03,800 --> 01:59:05,920 TECHNOLOGIES AND IMPROVE DATA 2529 01:59:05,920 --> 01:59:06,920 ACCESSIBILITY. 2530 01:59:06,920 --> 01:59:08,720 ALL OF THIS THROUGH THE LIFE 2531 01:59:08,720 --> 01:59:11,480 CYCLE OF THE DATA TO MAKE THINGS 2532 01:59:11,480 --> 01:59:13,840 OPEN, FAIR AND TRUST WORTHY. 2533 01:59:13,840 --> 01:59:16,840 BEFORE I DIG INTO THE DETAILS 2534 01:59:16,840 --> 01:59:19,920 I'D LIKE TO SHARE SOME THOUGHTS. 2535 01:59:19,920 --> 01:59:22,920 WE BELIEVE THAT IT'S IMPERATIVE 2536 01:59:22,920 --> 01:59:25,400 TO CONNECT RESOURCES TO MAKE 2537 01:59:25,400 --> 01:59:27,720 THEM COMPUTATIONALLY 2538 01:59:27,720 --> 01:59:28,080 DISCOVERABLE. 2539 01:59:28,080 --> 01:59:31,720 IN ORDER TO GET THIS BIG PICTURE 2540 01:59:31,720 --> 01:59:35,560 IN ORDER TO DETECT GAPS AND 2541 01:59:35,560 --> 01:59:40,120 ALLOW FOR BOTH HUMANS AND 2542 01:59:40,120 --> 01:59:43,960 MACHINES -- IT IS IMPORTANT TO 2543 01:59:43,960 --> 01:59:48,320 CONDUCT CAREFUL ALIGNMENT. 2544 01:59:48,320 --> 01:59:50,880 THE INTEREST GRATED DATA PAINTS 2545 01:59:50,880 --> 02:00:01,720 A MORE CA -- A MORE COMPREHENSIE 2546 02:00:04,320 --> 02:00:06,720 PICTURE. 2547 02:00:06,720 --> 02:00:09,240 WE UNIFY AND HARNESS THIS WIDE 2548 02:00:09,240 --> 02:00:12,240 RANGE OF DATA USING DATA 2549 02:00:12,240 --> 02:00:13,040 INTEGRATION. 2550 02:00:13,040 --> 02:00:16,600 WE INCREASE UTILITY FOR 2551 02:00:16,600 --> 02:00:18,720 RESEARCHERS ACROSS DISEASES AND 2552 02:00:18,720 --> 02:00:19,920 ACROSS SPECIES. 2553 02:00:19,920 --> 02:00:25,960 AND WE ALSO DO THIS BY 2554 02:00:25,960 --> 02:00:35,160 GALVANIZING. 2555 02:00:35,160 --> 02:00:38,120 ACROSS A WIDE RANGE OF 2556 02:00:38,120 --> 02:00:39,920 ORGANISMS. 2557 02:00:39,920 --> 02:00:42,560 AND BY MAXIMIZING DATA REUSE 2558 02:00:42,560 --> 02:00:45,400 FROM A DESPERATE LANDSCAPE OF 2559 02:00:45,400 --> 02:00:47,160 DISEASE WE BELIEVE THAT WE'RE 2560 02:00:47,160 --> 02:00:50,000 FILLING THIS CRITICAL GAP IN THE 2561 02:00:50,000 --> 02:00:52,320 AVAILABILITY OF THE GENOTYPE 2562 02:00:52,320 --> 02:00:53,240 DATA. 2563 02:00:53,240 --> 02:00:56,120 WE'VE BEEN WORKING ON CREATING 2564 02:00:56,120 --> 02:00:59,880 TOOLS TO HARMONIZE DATA FOR 2565 02:00:59,880 --> 02:01:01,200 COMPUTATIONAL ISSUE. 2566 02:01:01,200 --> 02:01:03,480 WE UNDERSTAND THE LACK OF 2567 02:01:03,480 --> 02:01:05,160 CONSISTENCY CURATES DIFFERENT 2568 02:01:05,160 --> 02:01:09,000 ASSOCIATIONS SUCH AS THE DISEASE 2569 02:01:09,000 --> 02:01:09,480 VARIENT. 2570 02:01:09,480 --> 02:01:12,320 IT IS VERY CHALLENGING. 2571 02:01:12,320 --> 02:01:16,600 WE INCLUDE FINDING BEST 2572 02:01:16,600 --> 02:01:18,080 PRACTICES AND COMMUNITY 2573 02:01:18,080 --> 02:01:20,600 DEVELOPMENT OF SPECIES AND 2574 02:01:20,600 --> 02:01:23,160 ONTOLOGIES. 2575 02:01:23,160 --> 02:01:34,000 MAN O DAND THE WIDE RANGING IMPF 2576 02:01:38,120 --> 02:01:40,840 MONARCH RESOURCES WE BELIEVE IS 2577 02:01:40,840 --> 02:01:41,920 UNDERSTATED. 2578 02:01:41,920 --> 02:01:46,240 STANDARDIZING THE ENTIRETY OF 2579 02:01:46,240 --> 02:01:48,880 ANATOMY. 2580 02:01:48,880 --> 02:01:51,400 SUPPORTING OTHER RESOURCES AND 2581 02:01:51,400 --> 02:01:52,640 THEIR EFFORTS. 2582 02:01:52,640 --> 02:01:58,640 TO BE INNER OPERABLE. 2583 02:01:58,640 --> 02:02:02,400 WE ACT AS COMMISSIONS AND 2584 02:02:02,400 --> 02:02:05,480 RESEARCHERS. 2585 02:02:05,480 --> 02:02:09,000 I'LL DIG MORE IN TO THIS IN HOW 2586 02:02:09,000 --> 02:02:10,960 WE IMPACT THE COMMUNITY. 2587 02:02:10,960 --> 02:02:12,400 THE INTEGRATION ASPECT. 2588 02:02:12,400 --> 02:02:17,240 BY MAKING DATA MORE INNER 2589 02:02:17,240 --> 02:02:19,320 OPERABLE WE HELP SUPPORT A WIDE 2590 02:02:19,320 --> 02:02:29,880 RANGE OF DATA SHARING AND REUSE. 2591 02:02:30,360 --> 02:02:36,440 AND THE MONDO DISEASE ONTOLOGY 2592 02:02:36,440 --> 02:02:42,160 -- SO COMBINED -- INTO AN 2593 02:02:42,160 --> 02:02:45,560 ONTOLOGY THAT IS COHERENT. 2594 02:02:45,560 --> 02:02:49,680 AND IT HAS ALSO BEEN A 2595 02:02:49,680 --> 02:02:51,880 MULTIPLIER EFFECT BECAUSE IT 2596 02:02:51,880 --> 02:02:53,560 BRINGS EXPERTS AND STAKEHOLDERS 2597 02:02:53,560 --> 02:02:55,880 THAT CAN WORK TOGETHER TO FIGURE 2598 02:02:55,880 --> 02:02:59,760 OUT HOW TO BEST CATEGORIZE 2599 02:02:59,760 --> 02:03:00,440 DISEASE. 2600 02:03:00,440 --> 02:03:02,080 THIS IS ANOTHER EXAMPLE OF 2601 02:03:02,080 --> 02:03:04,040 INTEGRATION WHERE WE SHARE 2602 02:03:04,040 --> 02:03:05,400 INFORMATION THAT HAS BEEN AND IT 2603 02:03:05,400 --> 02:03:11,520 HAS BEEN DESIGNATED AS A 2604 02:03:11,520 --> 02:03:14,920 STANDARD. 2605 02:03:14,920 --> 02:03:16,880 LASTLY ANOTHER EXAMPLE OF 2606 02:03:16,880 --> 02:03:18,640 INTEGRATION HAS BEEN THE HBO 2607 02:03:18,640 --> 02:03:21,840 WHICH IS MADE MORE ACCESSIBLE BY 2608 02:03:21,840 --> 02:03:25,720 BEING TRANSLATED INTO 20 2609 02:03:25,720 --> 02:03:29,280 DIFFERENT LANGUAGES. 2610 02:03:29,280 --> 02:03:31,080 SOME OF THE STANDARDS INCLUDE 2611 02:03:31,080 --> 02:03:35,440 THE LINK ML BASED KNOWLEDGE -- 2612 02:03:35,440 --> 02:03:45,680 BIOLINK MODEL. 2613 02:03:46,640 --> 02:03:50,880 THIS IS A PIPELINE THAT SUPPORTS 2614 02:03:50,880 --> 02:03:59,240 -- THE HETEROGENOUS LANDSCAPE. 2615 02:03:59,240 --> 02:04:02,840 AND THEM OUR STANDARD FOR 2616 02:04:02,840 --> 02:04:05,440 SHARING PHENOTYPIC DATA. 2617 02:04:05,440 --> 02:04:07,280 AND MANY 2618 02:04:07,280 --> 02:04:11,560 ONTOLOGIES THAT ARE WIDELY USED 2619 02:04:11,560 --> 02:04:22,280 STANDARDS IN AT PHENOTYPE AND 2620 02:04:22,600 --> 02:04:23,520 ONTOLOGY. 2621 02:04:23,520 --> 02:04:26,520 AND THE ENVIRONMENTAL EXPOSURE 2622 02:04:26,520 --> 02:04:27,400 ONTOLOGY. 2623 02:04:27,400 --> 02:04:37,880 THE UNIFIED ANATOMY AND THE 2624 02:04:43,600 --> 02:04:49,320 PHENOTYPE ONTOLOGY. 2625 02:04:49,320 --> 02:04:54,480 SO OUR GOAL IS TO DOUBLE THE 2626 02:04:54,480 --> 02:04:58,280 TRANSLATIONAL RESEARCH. 2627 02:04:58,280 --> 02:05:02,080 WE TRY TO RECOMMEND HEALTH 2628 02:05:02,080 --> 02:05:02,520 CHALLENGES. 2629 02:05:02,520 --> 02:05:04,920 THERE IS MORE IN THE LINKS. 2630 02:05:04,920 --> 02:05:10,760 BUT WE KNOW THAT IT'S CHAT 2631 02:05:10,760 --> 02:05:17,360 CHALLENGING * SO WE NEED MORE 2632 02:05:17,360 --> 02:05:19,000 DATA TO MAKE BETTER DIAGNOSIS 2633 02:05:19,000 --> 02:05:20,920 AND WE'VE BEEN TRYING TO HELP 2634 02:05:20,920 --> 02:05:24,240 IMPROVE THE SITUATION. 2635 02:05:24,240 --> 02:05:26,640 NOWADAYS ALMOST ALL TOOLS USE 2636 02:05:26,640 --> 02:05:29,880 THIS AND WE'VE DEMONSTRATED THIS 2637 02:05:29,880 --> 02:05:34,360 IN A NUMBER OF SETTINGS WITH THE 2638 02:05:34,360 --> 02:05:40,520 PROJECT THAT SEQUENCES GENOMES. 2639 02:05:40,520 --> 02:05:48,200 SO THE DIAGNOSTIC PIPELINE -- 2640 02:05:48,200 --> 02:05:54,760 AND THIS IDENTIFIES PATIENTS AND 2641 02:05:54,760 --> 02:05:58,040 IN THIS PARTICULAR PAPER FOUND 2642 02:05:58,040 --> 02:06:02,520 88% OF RARE DISEASES. 2643 02:06:02,520 --> 02:06:04,240 LASTLY I WOULD LIKE TO TALK 2644 02:06:04,240 --> 02:06:05,880 ABOUT OUR EFFORTS TO BRING THE 2645 02:06:05,880 --> 02:06:07,080 COMMUNITY TOGETHER AROUND THE 2646 02:06:07,080 --> 02:06:09,280 RESOURCE. 2647 02:06:09,280 --> 02:06:11,720 WE BELIEVE THAT MONARCH SERVES 2648 02:06:11,720 --> 02:06:14,520 IS A SOCIAL TECHNICAL MODEL FOR 2649 02:06:14,520 --> 02:06:18,400 THE CREATION AND FIT FOR PERFECT 2650 02:06:18,400 --> 02:06:22,320 STANDARDS. 2651 02:06:22,320 --> 02:06:24,320 LIBRARIES REQUIRE YEARS OF 2652 02:06:24,320 --> 02:06:25,200 DEVELOPMENT BUT YEARS OF 2653 02:06:25,200 --> 02:06:26,680 COMMUNITY BUILDING AND THESE 2654 02:06:26,680 --> 02:06:30,000 RESOURCES ARE USED ACROSS THE 2655 02:06:30,000 --> 02:06:32,440 BIODATA RESOURCE ECOSYSTEM 2656 02:06:32,440 --> 02:06:35,440 INCLUDING SOME LARGE OPEN 2657 02:06:35,440 --> 02:06:37,520 SCIENCE EFFORTS THAT WERE FUNDED 2658 02:06:37,520 --> 02:06:42,400 BY THE NIH. 2659 02:06:42,400 --> 02:06:44,160 AND THESE PROJECTS WOULD ALSO 2660 02:06:44,160 --> 02:06:46,080 HAVE TO SOCIALIZE THEIR OWN 2661 02:06:46,080 --> 02:06:47,920 STANDARDS. 2662 02:06:47,920 --> 02:06:51,560 IN RESOURCES -- SUCH AS MUNDO 2663 02:06:51,560 --> 02:06:53,840 AND HBO. 2664 02:06:53,840 --> 02:06:58,120 WE HOPE TO DEMOCRATIZE. 2665 02:06:58,120 --> 02:07:01,000 I WOULD LIKE TO SAY GOOD-BYE BY 2666 02:07:01,000 --> 02:07:02,760 INTRODUCING THE TEAM. 2667 02:07:02,760 --> 02:07:05,280 TO THE TEAM BEHIND ALL OF THIS 2668 02:07:05,280 --> 02:07:07,440 WORK AND AS YOU MAY HAVE CAUGHT 2669 02:07:07,440 --> 02:07:10,160 ON THE TEAM UNDERLYING MONARCH'S 2670 02:07:10,160 --> 02:07:11,480 SUCCESS IS OUR TEAMWORK. 2671 02:07:11,480 --> 02:07:14,680 WE HAVE AN INTERNATIONAL TEAM 2672 02:07:14,680 --> 02:07:16,520 THAT COMES TOGETHER WEEK AFTER 2673 02:07:16,520 --> 02:07:18,320 WEEK TO HELP MOVE FORWARD THESE 2674 02:07:18,320 --> 02:07:25,280 RESOURCES. 2675 02:07:25,280 --> 02:07:31,560 AND I HAVE THE PRIVILEGE OF 2676 02:07:31,560 --> 02:07:33,200 BEING THE PROGRAM DIRECTOR. 2677 02:07:33,200 --> 02:07:38,640 WE HAVE THE NAMES OF THE TEAM. 2678 02:07:38,640 --> 02:07:42,040 AND I WOULD LIKE TO THANK ALL OF 2679 02:07:42,040 --> 02:07:47,080 YOU. 2680 02:07:47,080 --> 02:07:50,840 WE KNOW THAT SOME VIEW MONARCH 2681 02:07:50,840 --> 02:07:52,920 AS THE TRUE DATA RESEARCH 2682 02:07:52,920 --> 02:07:54,840 PARASITE BUT THROUGH COMMUNITY 2683 02:07:54,840 --> 02:07:57,920 PARTNERSHIPS AND THROUGH OUR 2684 02:07:57,920 --> 02:08:01,560 HARMONIZATION MANY SOURCES HAVE 2685 02:08:01,560 --> 02:08:04,880 IMPROVED THEIR DATA PROVISIONS, 2686 02:08:04,880 --> 02:08:06,480 THEIR STANDARDIZATION AND THEIR 2687 02:08:06,480 --> 02:08:11,640 LICENSING AND THEIR COMMUNITY 2688 02:08:11,640 --> 02:08:19,280 ENGAGEMENT. 2689 02:08:19,280 --> 02:08:23,400 IT HAS HELPED THE COLLABORATION. 2690 02:08:23,400 --> 02:08:25,320 WE'RE EXCITED TO BE HERE TODAY 2691 02:08:25,320 --> 02:08:26,040 AND TALKING. 2692 02:08:26,040 --> 02:08:29,360 AND I THANK YOU FOR YOUR TIME. 2693 02:08:29,360 --> 02:08:31,000 >>THANK YOU SO MUCH. 2694 02:08:31,000 --> 02:08:33,400 MONICA FOR THIS GREAT OVERVIEW. 2695 02:08:33,400 --> 02:08:43,920 AND NOW WE HAVE NICOLAE DONE. 2696 02:08:44,640 --> 02:08:50,920 IF YOU WANT TO GO AHEAD AND TALK 2697 02:08:50,920 --> 02:08:53,920 ABOUT THE FORUM. 2698 02:08:53,920 --> 02:09:01,080 I DON'T SEE YOUR SLIDES YET. 2699 02:09:01,080 --> 02:09:01,920 VERY GOOD. 2700 02:09:01,920 --> 02:09:04,400 BUT WE DON'T HEAR YOU OR SEE YOU 2701 02:09:04,400 --> 02:09:07,120 IF YOU'RE TALKING. 2702 02:09:07,120 --> 02:09:10,360 >>CAN YOU HEAR ME? 2703 02:09:10,360 --> 02:09:12,200 >>A BIT FAINT. 2704 02:09:12,200 --> 02:09:14,040 >>CAN YOU SEE ME NOW? 2705 02:09:14,040 --> 02:09:14,520 >>YEP. 2706 02:09:14,520 --> 02:09:16,720 WE CAN SEE AND HEAR YOU AND SEE 2707 02:09:16,720 --> 02:09:18,120 YOUR SLIDES. 2708 02:09:18,120 --> 02:09:18,640 >>GREAT. 2709 02:09:18,640 --> 02:09:20,760 THANKS SO MUCH. 2710 02:09:20,760 --> 02:09:23,040 HELLO, EVERYONE. 2711 02:09:23,040 --> 02:09:25,280 MY NAME IS NICOLAE DONE. 2712 02:09:25,280 --> 02:09:27,840 I'M A MANAGER AT ANALYSIS GROUP 2713 02:09:27,840 --> 02:09:29,840 AND I'M DELIGHTED TO SHARE WITH 2714 02:09:29,840 --> 02:09:33,520 YOU TODAY OUR WORK ON 2715 02:09:33,520 --> 02:09:36,360 COLLABORATIVE DATA SHARE AND 2716 02:09:36,360 --> 02:09:39,200 REUSE IN THE RARE DISEASE SPACE. 2717 02:09:39,200 --> 02:09:44,000 I'M ALSO REPRESENTING A LARGE 2718 02:09:44,000 --> 02:09:46,840 INTERDISCIPLINARY TEAM OF 2719 02:09:46,840 --> 02:09:48,000 RESEARCHERS AND PATIENT 2720 02:09:48,000 --> 02:09:48,440 ADVOCATES. 2721 02:09:48,440 --> 02:09:51,640 OUR WORK WAS FUNDED BY THE 2722 02:09:51,640 --> 02:09:53,640 RESEARCH CONSORTIUM. 2723 02:09:53,640 --> 02:09:57,800 A NONPROFIT ORGANIZATION THAT 2724 02:09:57,800 --> 02:10:01,000 AIMS TO ACCELERATE AND ALSO GIVE 2725 02:10:01,000 --> 02:10:03,680 ACCESS TO NEW TREATMENTS AND TO 2726 02:10:03,680 --> 02:10:05,480 DRIVE ADVANCES IN THE AWARENESS 2727 02:10:05,480 --> 02:10:08,520 OF SCIENCE IN THE TREATMENT OF 2728 02:10:08,520 --> 02:10:11,320 THESE DISEASES. 2729 02:10:11,320 --> 02:10:17,200 THIS RESEARCH IS ALSO CONDUCTED 2730 02:10:17,200 --> 02:10:21,400 UNDER THE EMILY DOZEN FORUM. 2731 02:10:21,400 --> 02:10:26,880 * AND THE STUDY INVOLVES THE 2732 02:10:26,880 --> 02:10:29,400 VIOLATION OF A CARDIAC 2733 02:10:29,400 --> 02:10:30,040 BIOMARKER. 2734 02:10:30,040 --> 02:10:37,920 BIOMARKER. 2735 02:10:37,920 --> 02:10:40,600 AND JUST TO GIVE YOU MORE OF A 2736 02:10:40,600 --> 02:10:42,720 BACKGROUND ABOUT THIS DISEASE. 2737 02:10:42,720 --> 02:10:45,560 THIS IS A RARE AND ALSO 2738 02:10:45,560 --> 02:10:47,960 PROGRESSIVE OFTEN FATE A DISEASE 2739 02:10:47,960 --> 02:10:51,600 CAUSED BY THE ACCUMULATION OF 2740 02:10:51,600 --> 02:10:58,640 SO-CALLED AMYLOID IN DIFFERENT 2741 02:10:58,640 --> 02:10:59,480 ORGANS. 2742 02:10:59,480 --> 02:11:01,280 A VARIETY OF SYMPTOMS FROM 2743 02:11:01,280 --> 02:11:03,240 DIZZINESS TO FATIGUE TO HEART 2744 02:11:03,240 --> 02:11:06,040 AND KIDNEY FAILURE. 2745 02:11:06,040 --> 02:11:11,200 A VERY DEBILITATING DISEASE AND 2746 02:11:11,200 --> 02:11:15,720 HIGHLY PET OHIO AGAIN US. 2747 02:11:15,720 --> 02:11:19,760 -- HETEROGENEOUS. 2748 02:11:19,760 --> 02:11:23,760 *. 2749 02:11:23,760 --> 02:11:29,440 CARDIAC INVOLVEMENT IS THE MOST 2750 02:11:29,440 --> 02:11:32,560 COMMON AND THE EXTENT TO WHICH 2751 02:11:32,560 --> 02:11:35,320 CARDIAC INVOLVEMENT IS PRESENT 2752 02:11:35,320 --> 02:11:38,200 TENDS TO BE A VERY GOOD 2753 02:11:38,200 --> 02:11:39,640 PREDICTOR OF MORTALITY IN 2754 02:11:39,640 --> 02:11:40,640 PARTICULAR. 2755 02:11:40,640 --> 02:11:44,160 SO JUST TO ILLUSTRATE MEDIUM 2756 02:11:44,160 --> 02:11:46,720 SURVIVAL TIME FOR PATIENTS WITH 2757 02:11:46,720 --> 02:11:49,400 SEVERE CARDIAC INVOLVEMENT IS 2758 02:11:49,400 --> 02:11:51,280 LESS THAN ONE YEAR. 2759 02:11:51,280 --> 02:11:54,920 WHERE FOR THOSE WITHOUT CARDIAC 2760 02:11:54,920 --> 02:11:56,560 INVOLVEMENT IS 8 YEARS. 2761 02:11:56,560 --> 02:11:58,680 A HUGE DIFFERENCE. 2762 02:11:58,680 --> 02:12:02,240 ABOUT ONE THIRD OF EARLY DEATHS 2763 02:12:02,240 --> 02:12:06,440 WITHIN 90 DAYS OF DIAGNOSIS ARE 2764 02:12:06,440 --> 02:12:08,640 ATTRIBUTED TO CARDIAC 2765 02:12:08,640 --> 02:12:09,560 INVOLVEMENT. 2766 02:12:09,560 --> 02:12:11,880 SO CURRENTLY THERE ARE VERY FEW 2767 02:12:11,880 --> 02:12:14,080 TREATMENTS THAT ARE EFFECTIVE. 2768 02:12:14,080 --> 02:12:16,960 THERE WAS ONE TREATMENT APPROVED 2769 02:12:16,960 --> 02:12:18,520 IN 2021 BUT IN GENERAL THERE ARE 2770 02:12:18,520 --> 02:12:19,840 NOT MANY OPTIONS. 2771 02:12:19,840 --> 02:12:23,680 AND THIS SITUATION REFLECTS THE 2772 02:12:23,680 --> 02:12:26,680 FACT THAT DRUG DEVELOPMENT IS 2773 02:12:26,680 --> 02:12:28,720 EXTREMELY DIFFICULT IN THIS 2774 02:12:28,720 --> 02:12:30,400 SPACE FOR REASONS THAT ARE 2775 02:12:30,400 --> 02:12:34,720 COMMON TO OTHER RARE DISEASES. 2776 02:12:34,720 --> 02:12:36,600 RELATED TO THE AUDIENCE 2777 02:12:36,600 --> 02:12:47,160 INCLUDING PROHIBIT -- COSTLY AND 2778 02:12:48,280 --> 02:12:50,240 LENGTHY CLINICAL TRIALS. 2779 02:12:50,240 --> 02:12:51,560 AND IN ADDITION TO THE 2780 02:12:51,560 --> 02:12:53,120 DIFFICULTIES OF CONDUCTING 2781 02:12:53,120 --> 02:12:54,600 CLINICAL TRIALS IN THE FIRST 2782 02:12:54,600 --> 02:12:56,720 PLACE THERE ARE MANY BARRIERS 2783 02:12:56,720 --> 02:12:59,960 THAT PREVENT OR LIMIT THE 2784 02:12:59,960 --> 02:13:02,640 SHARING OF DATA. 2785 02:13:02,640 --> 02:13:07,800 WHICH TEND TO END UP SILOED AT 2786 02:13:07,800 --> 02:13:11,920 MEDICAL INSTITUTIONS AND MEDICAL 2787 02:13:11,920 --> 02:13:14,600 CENTERS. 2788 02:13:14,600 --> 02:13:17,240 SO HERE I'M ONLY MENTIONING A 2789 02:13:17,240 --> 02:13:18,480 FEW OF THE MOST IMPORTANT 2790 02:13:18,480 --> 02:13:19,200 BARRIERS. 2791 02:13:19,200 --> 02:13:23,000 BUT IT'S ALSO WORTH NOTING THAT 2792 02:13:23,000 --> 02:13:27,680 THESE BARRIERS OFTEN STEM FROM 2793 02:13:27,680 --> 02:13:30,440 VERY LEGITIMATE UNDERSTANDABLE 2794 02:13:30,440 --> 02:13:32,320 CONCERNS OF PROTECTION OF 2795 02:13:32,320 --> 02:13:34,160 PATIENT'S PRIVACY OR CONCERNS 2796 02:13:34,160 --> 02:13:38,240 THAT THE DATA WILL BE MISUSED OR 2797 02:13:38,240 --> 02:13:39,000 MISINTERPRETED. 2798 02:13:39,000 --> 02:13:41,440 SO SIMPLY FROM VARIOUS 2799 02:13:41,440 --> 02:13:43,640 LIMITATIONS AND THE TECHNICAL 2800 02:13:43,640 --> 02:13:46,200 AND FINANCIAL INSTITUTIONAL 2801 02:13:46,200 --> 02:13:48,480 CAPACITY TO SHARE THE DATA. 2802 02:13:48,480 --> 02:13:51,680 SO I JUST WANT TO EMPHASIZE THE 2803 02:13:51,680 --> 02:13:53,680 POINT THAT MAY BE OBVIOUS TO YOU 2804 02:13:53,680 --> 02:13:55,280 BUT IT'S STILL IMPORTANT TO 2805 02:13:55,280 --> 02:13:59,680 HIGHLIGHT IS THAT DATA IS NOT 2806 02:13:59,680 --> 02:14:04,760 RANDOM BYTES FLOATING THROUGH. 2807 02:14:04,760 --> 02:14:07,880 FREEING IT UP FOR REUSE AND 2808 02:14:07,880 --> 02:14:11,240 HARNESSING IT FOR SCIENTIFIC 2809 02:14:11,240 --> 02:14:16,000 RESEARCH NEEDS TO BE DONE 2810 02:14:16,000 --> 02:14:25,760 THOUGHTFULLY AND RESPONSIBLY. 2811 02:14:25,760 --> 02:14:28,760 THE IDENTIFICATION OF SURROGATE 2812 02:14:28,760 --> 02:14:33,080 END POINTS WHICH ARE MEASURES 2813 02:14:33,080 --> 02:14:34,920 THAT ARE NOT THEMSELVES DIRECT 2814 02:14:34,920 --> 02:14:37,200 MEASUREMENTS OF CLINICAL BENEFIT 2815 02:14:37,200 --> 02:14:39,720 BUT ARE KNOWN TO PREDICT 2816 02:14:39,720 --> 02:14:41,400 CLINICAL BENEFIT AND CAN BE USED 2817 02:14:41,400 --> 02:14:43,840 TO DEMONSTRATE IT EITHER ALONG 2818 02:14:43,840 --> 02:14:49,040 AN ACCELERATED OR TRADITIONAL 2819 02:14:49,040 --> 02:14:51,400 APPROVAL PATHWAY IN THE 2820 02:14:51,400 --> 02:14:56,000 REGULATORY FRAMEWORK. 2821 02:14:56,000 --> 02:15:01,200 SO IN PARTICULAR THERE IS ONE 2822 02:15:01,200 --> 02:15:04,840 BIOMARKER CALLED THE -- VERY 2823 02:15:04,840 --> 02:15:14,360 LONG -- A MOUTHFUL OR NTOB FOR 2824 02:15:14,360 --> 02:15:16,680 SHORT. 2825 02:15:16,680 --> 02:15:21,000 IT'S ESSENTIALLY A SIGNALING A 2826 02:15:21,000 --> 02:15:23,640 MOLECULE THAT WAS LEVEL IN 2827 02:15:23,640 --> 02:15:25,560 INCREASES IN BLOOD WHEN THE 2828 02:15:25,560 --> 02:15:28,080 HEART MUSCLE IS UNDER STRESS AND 2829 02:15:28,080 --> 02:15:31,640 ALSO A USEFUL BIOMARKER IN HEART 2830 02:15:31,640 --> 02:15:32,720 FAILURE FOR EXAMPLE. 2831 02:15:32,720 --> 02:15:35,360 HOWEVER I WOULD NOTE THAT THE 2832 02:15:35,360 --> 02:15:38,720 UNDERLYING MECHANISM IS RELEASED 2833 02:15:38,720 --> 02:15:42,040 IN HIGHER QUANTITIES AND IT IS 2834 02:15:42,040 --> 02:15:43,560 DIFFERENT AT A PHYSIOLOGICAL 2835 02:15:43,560 --> 02:15:44,240 LEVEL. 2836 02:15:44,240 --> 02:15:45,920 WITHOUT GOING INTO ALL OF THE 2837 02:15:45,920 --> 02:15:48,480 CLINICAL DETAILS HERE SUFFICE TO 2838 02:15:48,480 --> 02:15:50,720 SAY THAT THE MECHANISM 2839 02:15:50,720 --> 02:15:53,400 UNDERLYING THE CHANGES IS QUITE 2840 02:15:53,400 --> 02:15:55,280 WELL UNDERSTOOD BY CLINICIANS 2841 02:15:55,280 --> 02:15:57,360 AND RESEARCHERS. 2842 02:15:57,360 --> 02:16:00,440 SCENES,LY THE BIOMARKERS SIGNAL 2843 02:16:00,440 --> 02:16:03,640 THAT THE CELLS ARE GETTING 2844 02:16:03,640 --> 02:16:05,320 SQUISHED AND UNDER INCREASED 2845 02:16:05,320 --> 02:16:07,640 STRESS AND THIS BIOMARKER IS 2846 02:16:07,640 --> 02:16:10,080 WELL UNDERSTOOD CLINICALLY. 2847 02:16:10,080 --> 02:16:13,280 BUT FROM A STATISTICAL POINT OF 2848 02:16:13,280 --> 02:16:15,520 VIEW THERE ARE THREE LEVELS OF 2849 02:16:15,520 --> 02:16:18,560 EVIDENCE THAT NEED TO BE 2850 02:16:18,560 --> 02:16:20,600 SATISFIED TO BE CONSIDERED A 2851 02:16:20,600 --> 02:16:22,480 VALIDATED SURROGATE FOR 2852 02:16:22,480 --> 02:16:24,800 SURVIVAL. 2853 02:16:24,800 --> 02:16:27,880 SO FIRST WE NEED TO KNOW THAT 2854 02:16:27,880 --> 02:16:33,520 THE LEVELS OF THE BIOMARKERS ARE 2855 02:16:33,520 --> 02:16:37,040 ASSOCIATED WITH SUBSEQUENT 2856 02:16:37,040 --> 02:16:41,480 SURVIVAL. 2857 02:16:41,480 --> 02:16:43,080 THE CHANGES IN THE BIOMARKER 2858 02:16:43,080 --> 02:16:45,880 LEVEL SHOULD BE PREDICTIVE OF 2859 02:16:45,880 --> 02:16:48,320 SURVIVAL AND AT THE THIRD LEVEL 2860 02:16:48,320 --> 02:16:50,320 THE DATA FROM MULTIPLE 2861 02:16:50,320 --> 02:16:51,760 INDEPENDENT STUDIES ARE NEEDED 2862 02:16:51,760 --> 02:16:56,040 TO DEMONSTRATE THE PREDICTIVE 2863 02:16:56,040 --> 02:17:01,840 ASSOCIATION. 2864 02:17:01,840 --> 02:17:12,360 SO FILES ARE NOW COMPLETED IN 2865 02:17:14,320 --> 02:17:16,240 DIFFERENT GEOGRAPHIC LOCATIONS 2866 02:17:16,240 --> 02:17:18,360 AND MANY MORE WILL COME ON-LINE 2867 02:17:18,360 --> 02:17:18,800 SOON. 2868 02:17:18,800 --> 02:17:21,400 AND WE HOPE TO INCORPORATE MANY 2869 02:17:21,400 --> 02:17:23,840 IN THE FUTURE BUT FOR NOW WE'RE 2870 02:17:23,840 --> 02:17:27,280 ABLE TO USE THE DATA FROM FOUR 2871 02:17:27,280 --> 02:17:29,720 TRIALS TWO CONDUCTED IN THE U.S. 2872 02:17:29,720 --> 02:17:33,000 AND ONE IN THE EUROPEAN UNION 2873 02:17:33,000 --> 02:17:40,400 AND ONE IN CHINA. 2874 02:17:40,400 --> 02:17:44,320 OUR OVER-ALL APPROACH TO MAKE 2875 02:17:44,320 --> 02:17:45,680 USE OF THIS WITHOUT BEING ABLE 2876 02:17:45,680 --> 02:17:48,360 TO ANALYZE IT GIVEN THAT IT IS 2877 02:17:48,360 --> 02:17:50,600 NOT SHAREABLE BY THE ACADEMIC 2878 02:17:50,600 --> 02:17:52,040 CENTERS THAT CONDUCTED THE 2879 02:17:52,040 --> 02:17:55,440 TRIALS IS TO USE FEDERATED 2880 02:17:55,440 --> 02:17:56,160 ANALYTICS. 2881 02:17:56,160 --> 02:17:59,440 SO USING WHAT IS CALLED A HUB 2882 02:17:59,440 --> 02:18:01,920 AND SPOKE PLATFORM WITH THE HUB 2883 02:18:01,920 --> 02:18:04,000 INCLUDING A CENTER, A RESEARCH 2884 02:18:04,000 --> 02:18:05,960 TEAM FROM ARC AND ANALYSIS 2885 02:18:05,960 --> 02:18:07,480 GROUP. 2886 02:18:07,480 --> 02:18:10,160 AND THIS TEAM THE CENTRAL TEAM 2887 02:18:10,160 --> 02:18:12,240 RESPONSIBLE FOR PUTTING TOGETHER 2888 02:18:12,240 --> 02:18:14,840 A COMMON DATA MODEL AND 2889 02:18:14,840 --> 02:18:16,480 STATISTICAL ANALYSIS PLAN AND 2890 02:18:16,480 --> 02:18:18,640 PROGRAMMING ALL OF THE ANALYSIS 2891 02:18:18,640 --> 02:18:21,280 WHICH ARE THEN SHARED SECURING 2892 02:18:21,280 --> 02:18:25,920 WITH RESEARCHERS AT EACH OF THE 2893 02:18:25,920 --> 02:18:28,880 SPOKE INSTITUTIONS OR THE KIND 2894 02:18:28,880 --> 02:18:31,320 OF DIFFERENT CENTERS WHO WOULD 2895 02:18:31,320 --> 02:18:33,400 THEN TRANSFORM THE DATA 2896 02:18:33,400 --> 02:18:36,720 ACCORDING THE CDM AND REVIEW THE 2897 02:18:36,720 --> 02:18:43,440 OUTPUT AND SHARE AGGRAVATED AND 2898 02:18:43,440 --> 02:18:46,640 ANALYTICAL RESULTS WITH THE HUB. 2899 02:18:46,640 --> 02:18:48,640 I WANT TO SHOW THE NUMBER OF 2900 02:18:48,640 --> 02:18:50,640 PATIENTS THAT WE WERE ABLE TO 2901 02:18:50,640 --> 02:18:53,600 INCLUDE IN THE ANALYSIS. 2902 02:18:53,600 --> 02:18:56,160 SO AFTER ALL OF THE INCLUSION 2903 02:18:56,160 --> 02:18:59,920 AND EXCLUSION CRITERIA WERE 2904 02:18:59,920 --> 02:19:01,960 APPLIED MOST OF THE TRIALS BEING 2905 02:19:01,960 --> 02:19:05,200 PRETTY SMALL WE WERE ABLE TO 2906 02:19:05,200 --> 02:19:07,120 INCLUDE ALMOST 300 PATIENTS IN 2907 02:19:07,120 --> 02:19:11,040 THE LANDMARK ANALYSIS. 2908 02:19:11,040 --> 02:19:14,040 AND ULTIMATELY WE WERE ABLE TO 2909 02:19:14,040 --> 02:19:16,520 CONDUCT A META-ANALYSIS 2910 02:19:16,520 --> 02:19:19,080 COMBINING AND REUSING THE DATA 2911 02:19:19,080 --> 02:19:23,880 FROM THE TRIALS SO THIS BLOCK 2912 02:19:23,880 --> 02:19:31,560 HERE SHOWS THE RESULTS OF THE 2913 02:19:31,560 --> 02:19:34,960 MODEL META ANALYZING THE DATA. 2914 02:19:34,960 --> 02:19:38,760 WE HAVE SOME SIGNAL SO FROM EACH 2915 02:19:38,760 --> 02:19:40,520 INDIVIDUAL STUDY THAT THE 2916 02:19:40,520 --> 02:19:44,800 TREATMENT RESPONDER, THE 2917 02:19:44,800 --> 02:19:48,800 PATIENTS WHO LEVELS GO DOWN 2918 02:19:48,800 --> 02:19:50,440 SIGNIFYING IMPROVEMENT. 2919 02:19:50,440 --> 02:19:53,320 AND THIS IS THEN ASSOCIATED WITH 2920 02:19:53,320 --> 02:19:57,000 BETTER SURVIVAL OR LOWER RISK OF 2921 02:19:57,000 --> 02:19:58,120 SURVIVAL. 2922 02:19:58,120 --> 02:20:00,200 BUT EACH INDIVIDUAL STUDY ON ITS 2923 02:20:00,200 --> 02:20:02,440 OWN DOESN'T HAVE SUFFICIENT 2924 02:20:02,440 --> 02:20:03,080 POWER. 2925 02:20:03,080 --> 02:20:04,760 SUFFICIENT SAMPLE SIZE TO 2926 02:20:04,760 --> 02:20:07,960 DEMONSTRATE THIS EFFECT. 2927 02:20:07,960 --> 02:20:09,400 HOWEVER, BY POOLING THE 2928 02:20:09,400 --> 02:20:10,760 ESTIMATES FROM THE STUDY WE WERE 2929 02:20:10,760 --> 02:20:14,520 ABLE TO ESTIMATE AN OVER-ALL 2930 02:20:14,520 --> 02:20:19,240 INCIDENT RATIO OF .39 WHICH IS 2931 02:20:19,240 --> 02:20:21,680 STATISTICALLY SIGNIFICANT AND 2932 02:20:21,680 --> 02:20:24,320 SUGGEST A 61% LOWER RISK OF 2933 02:20:24,320 --> 02:20:29,720 DEATH AMONG THOSE WHO RESPOND. 2934 02:20:29,720 --> 02:20:31,160 MEANING THOSE WHOSE LEVELS OF 2935 02:20:31,160 --> 02:20:34,080 THIS BIOMARKER INCREASED BY AT 2936 02:20:34,080 --> 02:20:37,720 LEAST 30% OR 300 UNITS BY SIX 2937 02:20:37,720 --> 02:20:39,320 MONTHS AFTER THE TREATMENT 2938 02:20:39,320 --> 02:20:40,160 INITIATION. 2939 02:20:40,160 --> 02:20:43,920 SO THIS GIVES US INCREASED 2940 02:20:43,920 --> 02:20:45,320 CONFIDENCE THAT THIS BIOMARKER 2941 02:20:45,320 --> 02:20:48,960 CAN BE USED AS A SURROGATE 2942 02:20:48,960 --> 02:20:53,080 MEASURE FOR OVER-ALL SURVIVAL. 2943 02:20:53,080 --> 02:20:55,160 AND WE PRESENTED THESE RESULTS 2944 02:20:55,160 --> 02:20:59,800 LAST YEAR AT THE INTERNATIONAL 2945 02:20:59,800 --> 02:21:05,200 SYMPOSIUM AND WE'RE DEVELOPING A 2946 02:21:05,200 --> 02:21:06,880 MANUSCRIPT BASED ON THESE 2947 02:21:06,880 --> 02:21:11,880 RESULTS AT THE MOMENT AS WELL. 2948 02:21:11,880 --> 02:21:16,200 SO IN CONCLUSION I WANTED TO END 2949 02:21:16,200 --> 02:21:19,960 WITH JUST SAYING THAT OUR STUDY 2950 02:21:19,960 --> 02:21:22,320 DEMONSTRATED SUCCESSFUL DATA 2951 02:21:22,320 --> 02:21:24,760 SHARING AND REUSE CASE FOR 2952 02:21:24,760 --> 02:21:26,200 COLLABORATIVE LEARNING IN THE 2953 02:21:26,200 --> 02:21:28,840 AREA DISEASE SPACE. 2954 02:21:28,840 --> 02:21:30,840 AND SPECIFICALLY IN THE SEVERE 2955 02:21:30,840 --> 02:21:35,800 AND PROGRESSIVE DISEASE LIKE AM 2956 02:21:35,800 --> 02:21:36,800 LEO DOSES. 2957 02:21:36,800 --> 02:21:40,280 * AND THE VALIDATION OF THE PART 2958 02:21:40,280 --> 02:21:42,720 OF THE BIOMARKER THAT CAN BE 2959 02:21:42,720 --> 02:21:45,840 USED AS A SURROGATE END POINT IN 2960 02:21:45,840 --> 02:21:48,680 FUTURE STUDIES. 2961 02:21:48,680 --> 02:21:51,160 BECAUSE OUR PLATFORM WAS 2962 02:21:51,160 --> 02:21:54,240 DESIGNED TO BE MODULAR IT CAN BE 2963 02:21:54,240 --> 02:21:55,840 EXTENDED TO INCORPORATE NEW 2964 02:21:55,840 --> 02:21:57,920 STUDIES AND OUTCOMES AND ALSO 2965 02:21:57,920 --> 02:21:58,800 ANALYSIS. 2966 02:21:58,800 --> 02:22:02,360 AND WE USED OPEN SOURCE 2967 02:22:02,360 --> 02:22:04,360 ANALYTICAL TOOLS AND RELIED ON 2968 02:22:04,360 --> 02:22:10,480 COMMON DATA MODEL BASED ON DATA 2969 02:22:10,480 --> 02:22:13,080 FORMATS AND ALSO MAKE OUR CODE 2970 02:22:13,080 --> 02:22:16,040 AND DOCUMENTATION AVAILABLE TO 2971 02:22:16,040 --> 02:22:17,600 OTHERS. 2972 02:22:17,600 --> 02:22:19,760 SO I'LL STOP HERE AND BEFORE I 2973 02:22:19,760 --> 02:22:22,120 DO THAT I'LL ACKNOWLEDGE THE 2974 02:22:22,120 --> 02:22:24,120 MANY WONDERFUL FOLKS AND 2975 02:22:24,120 --> 02:22:25,760 INSTITUTIONS WHO MADE THIS 2976 02:22:25,760 --> 02:22:27,360 PROJECT POSSIBLE INCLUDING THE 2977 02:22:27,360 --> 02:22:28,680 INDUSTRY AND RESEARCH GROUPS WHO 2978 02:22:28,680 --> 02:22:31,760 SHARED THEIR DATA FOR THE 2979 02:22:31,760 --> 02:22:35,200 GREATER BENEFIT OF THE 2980 02:22:35,200 --> 02:22:36,400 SCIENTIFIC COMMUNITIES. 2981 02:22:36,400 --> 02:22:38,720 THE FORUM FOR PROVIDING THE 2982 02:22:38,720 --> 02:22:40,600 SCIENTIFIC EXPERTISE AND 2983 02:22:40,600 --> 02:22:43,760 INSTITUTIONAL GUIDANCE. 2984 02:22:43,760 --> 02:22:45,960 THE RESEARCH CONSORTIUM WHO 2985 02:22:45,960 --> 02:22:46,960 SPONSORED THE PROJECT. 2986 02:22:46,960 --> 02:22:50,080 AND MY TEAM AT THE ANALYSIS 2987 02:22:50,080 --> 02:22:53,200 GROUP WHO MADE THIS HAPPEN. 2988 02:22:53,200 --> 02:22:55,240 AND THANK YOU FOR LISTENING AND 2989 02:22:55,240 --> 02:22:57,000 I'M HAPPY TO ANSWER ANY 2990 02:22:57,000 --> 02:22:59,760 QUESTIONS AND I HAVE MY E-MAIL 2991 02:22:59,760 --> 02:23:02,520 HERE IN CASE ANYONE WANTS TO 2992 02:23:02,520 --> 02:23:06,360 E-MAIL QUESTIONS AS WELL. 2993 02:23:06,360 --> 02:23:09,240 >>THANK YOU SO MUCH FOR THIS 2994 02:23:09,240 --> 02:23:12,800 REALLY GOOD EXPLANATION AND 2995 02:23:12,800 --> 02:23:13,680 IMPACTFUL PROJECT. 2996 02:23:13,680 --> 02:23:18,040 NOW WE'LL MOVE ON TO GIULIO 2997 02:23:18,040 --> 02:23:18,920 FORMENTI. 2998 02:23:18,920 --> 02:23:22,440 BEFORE WE DO THAT I REMIND ME WE 2999 02:23:22,440 --> 02:23:25,160 HAVE SLIDO FOR QUESTIONS. 3000 02:23:25,160 --> 02:23:26,040 PLEASE POST YOUR QUESTIONS 3001 02:23:26,040 --> 02:23:28,680 THERE. 3002 02:23:28,680 --> 02:23:34,800 AGAIN THE NUMBER IS 1379. 3003 02:23:34,800 --> 02:23:35,920 GO AHEAD. 3004 02:23:35,920 --> 02:23:36,960 THANK YOU SO MUCH. 3005 02:23:36,960 --> 02:23:39,880 >>THANK YOU SO MUCH FOR THE 3006 02:23:39,880 --> 02:23:41,400 INVITATION. 3007 02:23:41,400 --> 02:23:43,080 I'M A RESEARCHER AND PROFESSOR 3008 02:23:43,080 --> 02:23:47,600 AT THE ROCKEFELLER UNIVERSITY. 3009 02:23:47,600 --> 02:23:52,800 SO TODAY I'M PRESENTING ABOUT 3010 02:23:52,800 --> 02:24:03,080 THE GENOME ARC. 3011 02:24:06,800 --> 02:24:12,680 I WILL BRIEFLY EXPLAIN. 3012 02:24:12,680 --> 02:24:15,040 REFERENCE GENOMES -- IT'S 3013 02:24:15,040 --> 02:24:17,480 SOMETHING FOUNDATIONAL FOR 3014 02:24:17,480 --> 02:24:19,560 BASICALLY MOST GENETIC STUDIES. 3015 02:24:19,560 --> 02:24:24,400 WE CAN DEFINE THEM AS ACCURATE 3016 02:24:24,400 --> 02:24:26,840 SEQUENCES REPRESENTING THEIR OWN 3017 02:24:26,840 --> 02:24:33,880 SPECIES. 3018 02:24:33,880 --> 02:24:37,400 AND OF COURSE THIS UNLOCKS MANY 3019 02:24:37,400 --> 02:24:43,680 STUDIES IN TERMS OF POPULATION 3020 02:24:43,680 --> 02:24:47,720 GENOMICS, GENOME WIDE 3021 02:24:47,720 --> 02:24:49,720 ASSOCIATION GENOMICS. 3022 02:24:49,720 --> 02:24:56,200 INCLUDING STRUCTURAL FEATURES, 3023 02:24:56,200 --> 02:24:57,840 MOBILE ELEMENT AND SO FORTH. 3024 02:24:57,840 --> 02:25:02,960 SO WHAT DO WE DO AND HOW DO YOU 3025 02:25:02,960 --> 02:25:04,520 RECONSTRUCT? 3026 02:25:04,520 --> 02:25:06,720 THE PROCESS IS AN A ASSEMBLY. 3027 02:25:06,720 --> 02:25:11,560 SO WE START WITH THE DNA 3028 02:25:11,560 --> 02:25:13,960 MOLECULES. 3029 02:25:13,960 --> 02:25:16,440 SO WE TAKE THE DNA. 3030 02:25:16,440 --> 02:25:21,000 IT HAS TO BE FERMENTED OR 3031 02:25:21,000 --> 02:25:23,000 PARTIALLY FERMENTED AND THEN WE 3032 02:25:23,000 --> 02:25:26,000 SEQUENCE IT. 3033 02:25:26,000 --> 02:25:28,360 RECONSTRUCTION OF THE FRAGMENTS 3034 02:25:28,360 --> 02:25:30,320 OF THE ORIGINAL SEQUENCE. 3035 02:25:30,320 --> 02:25:35,160 AND THEN RECONSTRUCT THE 3036 02:25:35,160 --> 02:25:36,600 ORIGINAL SEQUENCE. 3037 02:25:36,600 --> 02:25:38,520 THIS IS COMPLICATED BY FEATURES 3038 02:25:38,520 --> 02:25:39,560 OF THE GENOMES. 3039 02:25:39,560 --> 02:25:42,360 THE MOST CHALLENGING ONE HAS 3040 02:25:42,360 --> 02:25:50,000 BEEN REPETITIVE ELEMENTS. 3041 02:25:50,000 --> 02:25:53,640 THEY ARE REPRESENTED BY THE 3042 02:25:53,640 --> 02:25:54,040 ARROW. 3043 02:25:54,040 --> 02:25:56,960 7 AND DOWNSTREAM YOU HAVE THE 3044 02:25:56,960 --> 02:26:00,840 SAME SEQUENCE REPEATED. 3045 02:26:00,840 --> 02:26:03,840 AND TYPICALLY UNTIL A FEW YEARS 3046 02:26:03,840 --> 02:26:09,240 AGO PEOPLE USED SEQUENCES. 3047 02:26:09,240 --> 02:26:16,440 THE PROBLEM IS THAT IF YOU USE 3048 02:26:16,440 --> 02:26:25,760 SHORT READS -- IT'S CALLED -- 3049 02:26:25,760 --> 02:26:26,280 SEQUENCING. 3050 02:26:26,280 --> 02:26:28,720 AN INSTRUMENT THAT ALLOWS TO YOU 3051 02:26:28,720 --> 02:26:38,400 READ MUCH LONGER READS. 3052 02:26:38,400 --> 02:26:41,320 FROM 10 TO 100. 3053 02:26:41,320 --> 02:26:42,800 SO VERY LONG READS. 3054 02:26:42,800 --> 02:26:45,480 YOU'RE SIMPLIFYING YOUR 3055 02:26:45,480 --> 02:26:47,760 CONSTRUCTION PROBLEM BY 3056 02:26:47,760 --> 02:26:49,960 INTRODUCING THESE LONG READS. 3057 02:26:49,960 --> 02:26:51,560 THESE ARE VERY USEFUL AND OF 3058 02:26:51,560 --> 02:26:53,160 COURSE A LOT OF PEOPLE AROUND 3059 02:26:53,160 --> 02:26:55,040 THE WORLD ARE NOW CONTRIBUTING 3060 02:26:55,040 --> 02:26:58,600 TO GENERATING REFERENCE GENES 3061 02:26:58,600 --> 02:27:00,160 USING THESE NEW TECHNOLOGIES. 3062 02:27:00,160 --> 02:27:02,280 IN OUR CASE WE'RE PART OF THE 3063 02:27:02,280 --> 02:27:08,000 NETWORK AND PROJECT CALLED 3064 02:27:08,000 --> 02:27:09,400 FURTHER THE GAMES PROJECT. 3065 02:27:09,400 --> 02:27:16,480 THERE ARE THREE MAIN HUBS. 3066 02:27:16,480 --> 02:27:19,200 THE HUBS WHERE WE GENERATE THE 3067 02:27:19,200 --> 02:27:20,920 PRIMARY DATA. 3068 02:27:20,920 --> 02:27:24,360 AND THE GOAL IS TO GENERATE THEM 3069 02:27:24,360 --> 02:27:28,240 FOR ALL 70,000 INVERTEBRATE 3070 02:27:28,240 --> 02:27:29,000 SPECIES. 3071 02:27:29,000 --> 02:27:33,880 WE'RE PLANNING TO DO THIS IN 3072 02:27:33,880 --> 02:27:35,200 MULTIPLE PHASES. 3073 02:27:35,200 --> 02:27:38,000 THE GOAL IS TO REPRESENT EACH 3074 02:27:38,000 --> 02:27:39,760 ORDER OF THE VERTEBRATES WITH AT 3075 02:27:39,760 --> 02:27:42,960 LEAST ONE REPRESENTATIVE 3076 02:27:42,960 --> 02:27:44,040 SPECIES. 3077 02:27:44,040 --> 02:27:50,400 AND THEN WE'LL MOVE ON TO FAMILY 3078 02:27:50,400 --> 02:27:58,120 AND -- SPECIES. 3079 02:27:58,120 --> 02:28:01,920 AND THIS IS A BROAD NETWORK. 3080 02:28:01,920 --> 02:28:04,160 WE'RE NOT JUST THREE HUBS BUT 3081 02:28:04,160 --> 02:28:05,920 THERE IS HUNDREDS OF 3082 02:28:05,920 --> 02:28:09,240 COLLABORATORS ACROSS THE GLOBE 3083 02:28:09,240 --> 02:28:11,000 THAT CAN CONTRIBUTE BY PROVIDING 3084 02:28:11,000 --> 02:28:11,600 SAMPLES. 3085 02:28:11,600 --> 02:28:13,440 BY PROVIDING DATA. 3086 02:28:13,440 --> 02:28:14,840 THEY CONTRIBUTE BY PROVIDING 3087 02:28:14,840 --> 02:28:16,880 ANALYSIS. 3088 02:28:16,880 --> 02:28:20,200 SO THIS NETWORK IS WHAT REALLY 3089 02:28:20,200 --> 02:28:23,160 PROMPTED THE CREATION OF THE 3090 02:28:23,160 --> 02:28:23,720 GENOMEARK. 3091 02:28:23,720 --> 02:28:26,200 WE NEEDED A WAY TO BE ABLE TO 3092 02:28:26,200 --> 02:28:27,600 SHARE ACROSS THE NETWORK AND 3093 02:28:27,600 --> 02:28:30,600 ALSO WITH OTHER PEOPLE THAT ARE 3094 02:28:30,600 --> 02:28:31,280 STAKEHOLDERS. 3095 02:28:31,280 --> 02:28:33,880 THE DATA THAT WE WERE 3096 02:28:33,880 --> 02:28:34,360 GENERATING. 3097 02:28:34,360 --> 02:28:37,080 THIS IS THE TEAM HERE AT 3098 02:28:37,080 --> 02:28:37,640 ROCKEFELLER. 3099 02:28:37,640 --> 02:28:39,520 WE HAVE PEOPLE FROM THE 3100 02:28:39,520 --> 02:28:40,200 SEQUENCING LAB. 3101 02:28:40,200 --> 02:28:47,240 WE HAVE PEOPLE FROM THE 3102 02:28:47,240 --> 02:28:52,240 BIOINFORMATIC LAB. 3103 02:28:52,240 --> 02:28:55,440 SO WHAT IS THE GENOMEARK. 3104 02:28:55,440 --> 02:29:00,040 IT'S A POWERED REPOSITORY. 3105 02:29:00,040 --> 02:29:01,520 WE STORE EVERYTHING THAT WE 3106 02:29:01,520 --> 02:29:03,280 GENERATE IN THERE. 3107 02:29:03,280 --> 02:29:05,680 WE STORE THE RAW DATA. WE STORE 3108 02:29:05,680 --> 02:29:08,320 THE ASSEMBLIES. 3109 02:29:08,320 --> 02:29:10,760 THE FILES, METADATA AND WE 3110 02:29:10,760 --> 02:29:15,680 INTEGRATE ALL OF THIS INTO A 3111 02:29:15,680 --> 02:29:17,920 SERIES OF PORTALS WHERE THE DATA 3112 02:29:17,920 --> 02:29:20,880 BECOMES ACCESSIBLE TO EVERYONE. 3113 02:29:20,880 --> 02:29:24,880 THIS IS A PUBLICLY AVAILABLE LAB 3114 02:29:24,880 --> 02:29:31,240 SO WE'RE NOT PUTTING ANY EMBA 3115 02:29:31,240 --> 02:29:31,840 EMBARGO. 3116 02:29:31,840 --> 02:29:36,040 TH-- IT BECOMES IMMEDIATELY 3117 02:29:36,040 --> 02:29:39,000 AVAILABLE TO BE STUDIED. 3118 02:29:39,000 --> 02:29:41,440 SO THIS GENOMEARK ALLOWS US TO 3119 02:29:41,440 --> 02:29:44,680 SHARE DATA ACROSS THE DIFFERENT 3120 02:29:44,680 --> 02:29:48,600 SITES AND WITHIN THE NETWORK AND 3121 02:29:48,600 --> 02:29:49,840 ALLOWS ANYONE IN THE COMMUNITY 3122 02:29:49,840 --> 02:29:51,360 TO VISUALIZE IT. 3123 02:29:51,360 --> 02:29:55,320 HERE IS AN EXAMPLE OF ONE OF THE 3124 02:29:55,320 --> 02:29:56,520 PORTALS. 3125 02:29:56,520 --> 02:29:59,280 YOU CAN SEE WHAT ARE THE READS 3126 02:29:59,280 --> 02:30:01,200 THAT ARE AVAILABLE. 3127 02:30:01,200 --> 02:30:02,960 FOR A PARTICULAR TECHNOLOGY. 3128 02:30:02,960 --> 02:30:04,520 THE SECOND EXAMPLE, WE HAVE 3129 02:30:04,520 --> 02:30:06,320 THREE DIFFERENT DATA TYPES 3130 02:30:06,320 --> 02:30:07,880 AVAILABLE FOR THIS PARTICULAR 3131 02:30:07,880 --> 02:30:13,600 SPECIES. 3132 02:30:13,600 --> 02:30:16,400 YOU CAN CLICK ON THE LINK OR USE 3133 02:30:16,400 --> 02:30:23,760 THE COMMAND LINE. 3134 02:30:23,760 --> 02:30:27,560 IT CAN BE DOWNLOADED. 3135 02:30:27,560 --> 02:30:30,600 SO LET'S ZOOM IN TO ONE SPECIFIC 3136 02:30:30,600 --> 02:30:33,320 SPECIES. 3137 02:30:33,320 --> 02:30:35,680 YOU HAVE THE GENERAL DESCRIPTION 3138 02:30:35,680 --> 02:30:37,080 OF THE SPECIES. 3139 02:30:37,080 --> 02:30:38,920 A SECTION HERE WHICH IS MOST 3140 02:30:38,920 --> 02:30:39,440 IMPORTANT. 3141 02:30:39,440 --> 02:30:43,120 WHAT WE GENERATE WE ALSO MAKE 3142 02:30:43,120 --> 02:30:44,920 AVAILABLE IN THE PUBLIC 3143 02:30:44,920 --> 02:30:46,360 REPOSITORIES THAT ARE NOT 3144 02:30:46,360 --> 02:30:47,560 MAINTAINED BY US. 3145 02:30:47,560 --> 02:30:51,840 GENE BANK. 3146 02:30:51,840 --> 02:31:01,760 THE YOU A -- EUROPEAN ARCHIVE AD 3147 02:31:01,760 --> 02:31:04,200 AGAIN WE PUBLISH THE ASSEMBLIES, 3148 02:31:04,200 --> 02:31:06,720 THE RAW DATA AND SO FORTH. 3149 02:31:06,720 --> 02:31:08,480 BUT AT THE SAME TIME WE PROVIDE 3150 02:31:08,480 --> 02:31:10,600 OUR OWN STORAGE SYSTEM. 3151 02:31:10,600 --> 02:31:13,440 AND YOU CAN SEE HERE BELOW -- 3152 02:31:13,440 --> 02:31:16,200 YOU CAN HAVE ALL OF THE DATA 3153 02:31:16,200 --> 02:31:18,040 TYPES FOR THE PARTICULAR 3154 02:31:18,040 --> 02:31:21,240 SPECIES. 3155 02:31:21,240 --> 02:31:23,160 ADDITIONAL TECHNOLOGY THAT IS 3156 02:31:23,160 --> 02:31:25,320 USEFUL TO RECONSTRUCT THE GENOME 3157 02:31:25,320 --> 02:31:27,560 AND YOU CAN SEE SOME OF THE 3158 02:31:27,560 --> 02:31:31,200 STATISTICS AND THE NUMBER OF 3159 02:31:31,200 --> 02:31:34,640 BASES. 3160 02:31:34,640 --> 02:31:38,960 AND THEN BASICALLY YOU HAVE THE 3161 02:31:38,960 --> 02:31:40,440 ASSEMBLIES WHICH YOU CAN SEE 3162 02:31:40,440 --> 02:31:40,920 HERE. 3163 02:31:40,920 --> 02:31:42,360 AGAIN JUST CLICK ON THE LINK. 3164 02:31:42,360 --> 02:31:45,040 YOU WILL BE ABLE TO DOWNLOAD THE 3165 02:31:45,040 --> 02:31:47,080 GENOME AND THIS IS IN BATCHES SO 3166 02:31:47,080 --> 02:31:49,320 YOU CAN ACCESS ALL OF THE 3167 02:31:49,320 --> 02:31:54,160 GENOMES THAT ARE AVAILABLE AT 3168 02:31:54,160 --> 02:31:54,800 GENOMEARK. 3169 02:31:54,800 --> 02:32:00,080 YOU CAN ALSO HAVE ACCESS TO THE 3170 02:32:00,080 --> 02:32:06,320 MITOCHONDRIAL DNA IF INTERESTED. 3171 02:32:06,320 --> 02:32:12,080 A SERIES OF PROJECTS THAT ARE 3172 02:32:12,080 --> 02:32:15,520 GENERATING REFERENCE FOR 3173 02:32:15,520 --> 02:32:23,320 NONMODEL SPECIES. 3174 02:32:23,320 --> 02:32:25,120 SO WITH THAT I WOULD LIKE TO 3175 02:32:25,120 --> 02:32:30,040 THANK MY COLLABORATORS HERE AT 3176 02:32:30,040 --> 02:32:32,520 ROCKEFELLER AND I'M HAPPY TO 3177 02:32:32,520 --> 02:32:33,480 ANSWER QUESTIONS WITH THE REST 3178 02:32:33,480 --> 02:32:34,600 OF THE SPEAKERS. 3179 02:32:34,600 --> 02:32:35,080 THANK YOU VERY MUCH. 3180 02:32:35,080 --> 02:32:38,720 7 3181 02:32:38,720 --> 02:32:40,480 >>THANK YOU SO MUCH FOR THIS 3182 02:32:40,480 --> 02:32:41,360 PRESENTATION. 3183 02:32:41,360 --> 02:32:44,160 NOW I INVITE OUR PRESENTERS TO 3184 02:32:44,160 --> 02:32:48,200 COME BACK ON THE SCREEN FOR Q&A. 3185 02:32:48,200 --> 02:32:50,520 WE ALREADY HAVE A COUPLE OF 3186 02:32:50,520 --> 02:32:53,160 QUESTIONS ON OUR CHAT BUT I 3187 02:32:53,160 --> 02:32:57,320 INVITE AGAIN PEOPLE TO POST 3188 02:32:57,320 --> 02:32:58,120 MORE. 3189 02:32:58,120 --> 02:32:59,880 I'M GOING TO START WITH THE 3190 02:32:59,880 --> 02:33:01,120 FIRST QUESTION THAT IS TO ALL OF 3191 02:33:01,120 --> 02:33:03,960 YOU. 3192 02:33:03,960 --> 02:33:05,800 WHAT ARE YOUR METRICS FOR 3193 02:33:05,800 --> 02:33:08,480 SUCCESS AND HOW DO YOU ASSESS 3194 02:33:08,480 --> 02:33:10,360 WHETHER THESE RESOURCES ARE 3195 02:33:10,360 --> 02:33:12,440 ACHIEVING THEIR GOAL? 3196 02:33:12,440 --> 02:33:14,480 LET'S GO IN PRESENTATION ORDER. 3197 02:33:14,480 --> 02:33:16,920 MONICA, YOU WANT TO START? 3198 02:33:16,920 --> 02:33:17,200 >>SURE. 3199 02:33:17,200 --> 02:33:19,200 THANK YOU. 3200 02:33:19,200 --> 02:33:21,720 THIS IS GREAT. 3201 02:33:21,720 --> 02:33:25,080 OUR METRICS OF SUCCESS SHOULD BE 3202 02:33:25,080 --> 02:33:27,160 SOMETHING VERY EVIDENT AND OUR 3203 02:33:27,160 --> 02:33:29,320 ABILITY TO SEE THAT COMMUNITIES 3204 02:33:29,320 --> 02:33:31,120 THAT ARE BOTH UTILIZING THE 3205 02:33:31,120 --> 02:33:33,280 RESOURCES AND ALSO GETTING 3206 02:33:33,280 --> 02:33:34,840 RESULTS THAT ARE ALLOWING THEM 3207 02:33:34,840 --> 02:33:37,600 TO THRIVE. 3208 02:33:37,600 --> 02:33:41,000 FOR US THE ABILITY TO SEE REUSE 3209 02:33:41,000 --> 02:33:43,360 ACROSS A VARIETY OF RESOURCES 3210 02:33:43,360 --> 02:33:45,160 THAT ARE VERY WELL ESTABLISHED 3211 02:33:45,160 --> 02:33:47,440 SUCH AS SOME OF THE PROGRAMS AND 3212 02:33:47,440 --> 02:33:50,840 NIH AND SOME OF THE PROGRAMS 3213 02:33:50,840 --> 02:33:53,400 ACROSS THE WORLD AND THE FACT 3214 02:33:53,400 --> 02:33:56,480 THAT WE HAVE MANAGED TO GENERATE 3215 02:33:56,480 --> 02:34:00,000 BOTH STANDARDS AND INTEGRATE 3216 02:34:00,000 --> 02:34:03,760 RESOURCES THAT ARE BEING USED BY 3217 02:34:03,760 --> 02:34:07,400 OTHERS AND LEVERAGED IN ORDER TO 3218 02:34:07,400 --> 02:34:10,680 EMPOWER THE DISCOVERY PROCESS. 3219 02:34:10,680 --> 02:34:14,640 AND THERE ARE REFERENCES THAT WE 3220 02:34:14,640 --> 02:34:16,400 GET IN THE DOCUMENTS ARE SOME OF 3221 02:34:16,400 --> 02:34:17,920 THE WAYS THAT WE FEEL CONFIDENT 3222 02:34:17,920 --> 02:34:19,760 THAT WE'RE DOING THE RIGHT THING 3223 02:34:19,760 --> 02:34:24,240 AND THAT WE'RE ACTUALLY GETTING 3224 02:34:24,240 --> 02:34:26,400 TO THE MILESTONES TO BE ABLE TO 3225 02:34:26,400 --> 02:34:29,160 SAY THAT OUR RESOURCES ARE BEING 3226 02:34:29,160 --> 02:34:32,280 DONE IN AN INWARD MANNER BUT ARE 3227 02:34:32,280 --> 02:34:36,320 REFLECTED INTO A WIDER COMMUNITY 3228 02:34:36,320 --> 02:34:36,760 COMMUNITY. 3229 02:34:36,760 --> 02:34:39,080 AND THE NUMBER OF CONTRIBUTIONS 3230 02:34:39,080 --> 02:34:41,280 THAT WE GET BACK INTO OUR 3231 02:34:41,280 --> 02:34:42,000 RESOURCES. 3232 02:34:42,000 --> 02:34:44,280 WE GO OUT AND DO A LOT OF 3233 02:34:44,280 --> 02:34:48,000 OUTREACH TO TRY TO GET -- TO 3234 02:34:48,000 --> 02:34:49,160 DISSEMINATE THE RESEARCH TO THE 3235 02:34:49,160 --> 02:34:51,120 COMMUNITY AND THEN THE COMMUNITY 3236 02:34:51,120 --> 02:34:53,360 BECOMES SO INTERESTED THAT THEY 3237 02:34:53,360 --> 02:34:54,480 THEMSELVES WANT TO CONTRIBUTE TO 3238 02:34:54,480 --> 02:34:55,400 THE RESOURCES. 3239 02:34:55,400 --> 02:34:58,480 SO THE FACT THAT WE'VE BEEN ABLE 3240 02:34:58,480 --> 02:35:01,160 TO GATHER A FAITHFUL COMMUNITY 3241 02:35:01,160 --> 02:35:03,480 THAT WANTS TO WRITE TICKETS AND 3242 02:35:03,480 --> 02:35:06,280 GIVE US INFORMATION AND DO VERY 3243 02:35:06,280 --> 02:35:08,280 SPECIFIC TOPIC WORKSHOPS TELLS 3244 02:35:08,280 --> 02:35:09,840 US THAT WE'RE DOING SOMETHING 3245 02:35:09,840 --> 02:35:11,560 RIGHT. 3246 02:35:11,560 --> 02:35:13,280 >>THANK YOU. 3247 02:35:13,280 --> 02:35:17,360 WHO WANTS TO GO NEXT? 3248 02:35:17,360 --> 02:35:18,120 >>YEAH. 3249 02:35:18,120 --> 02:35:18,880 ABSOLUTELY. 3250 02:35:18,880 --> 02:35:22,720 I WOULD SAY FOR US AND I 3251 02:35:22,720 --> 02:35:26,360 IDENTIFIED TWO TWO AREAS WHERE 3252 02:35:26,360 --> 02:35:30,640 WE COULD SEE OR MEASURE SUCCESS. 3253 02:35:30,640 --> 02:35:34,280 ONE IS WHERE WE'RE ABLE TO 3254 02:35:34,280 --> 02:35:38,360 INCORPORATE ADDITIONAL TRIAL 3255 02:35:38,360 --> 02:35:40,600 DATA AND KIND OF WORK WITH 3256 02:35:40,600 --> 02:35:44,040 ADDITIONAL COLLABORATORS OR HAVE 3257 02:35:44,040 --> 02:35:47,480 THE MODEL -- THAT WE DEVELOPED 3258 02:35:47,480 --> 02:35:50,560 AND TO BE USED IN OTHER DISEASE 3259 02:35:50,560 --> 02:35:52,440 AREAS AND ANSWER OTHER 3260 02:35:52,440 --> 02:35:53,200 SCIENTIFIC QUESTIONS. 3261 02:35:53,200 --> 02:35:56,520 THAT WOULD BE ONE VERY IMPORTANT 3262 02:35:56,520 --> 02:35:58,920 MEASURE OF SUCCESS. 3263 02:35:58,920 --> 02:36:01,920 AND ANOTHER AREA WOULD BE ON THE 3264 02:36:01,920 --> 02:36:02,680 REGULATORY SIDE. 3265 02:36:02,680 --> 02:36:11,040 IF THE FDA DECIDES TO ALLOW DRUG 3266 02:36:11,040 --> 02:36:13,560 DEVELOPERS AND CLINICAL TRIAL 3267 02:36:13,560 --> 02:36:18,000 SPONSORS TO MEASURE DRUG 3268 02:36:18,000 --> 02:36:20,120 TREATMENT EFFECTS USING A 3269 02:36:20,120 --> 02:36:23,880 BIOMARKER TO ACCELERATE THE 3270 02:36:23,880 --> 02:36:27,640 INNOVATION AND DRUG DISCOVERY 3271 02:36:27,640 --> 02:36:29,800 THEN I WOULD THINK THAT WOULD BE 3272 02:36:29,800 --> 02:36:31,800 THE ULTIMATE MEASURE OF SUCCESS 3273 02:36:31,800 --> 02:36:34,000 BECAUSE IT REALLY RELATES TO THE 3274 02:36:34,000 --> 02:36:36,520 REAL IMPACT THAT IT CAN HAVE ON 3275 02:36:36,520 --> 02:36:41,560 PATIENTS. 3276 02:36:41,560 --> 02:36:44,920 >>YEP. 3277 02:36:44,920 --> 02:36:46,960 SO WE MEASURE OUR SUCCESS IN 3278 02:36:46,960 --> 02:36:48,600 DIFFERENT WAYS. 3279 02:36:48,600 --> 02:36:54,400 7 OUR PRIMARY GOAL IS TO 3280 02:36:54,400 --> 02:36:56,080 GENERATE GENOME OF SPECIES. 3281 02:36:56,080 --> 02:36:57,800 WE HAVE SPECIFIC TARGETS. 3282 02:36:57,800 --> 02:37:00,480 BUT AT THE SAME TIME IN TERMS OF 3283 02:37:00,480 --> 02:37:02,600 DAILY USE WHAT WE LOOK INTO IS 3284 02:37:02,600 --> 02:37:04,680 HOW MUCH IMPACT WE HAVE ON THE 3285 02:37:04,680 --> 02:37:06,480 SCIENTIFIC COMMUNITY THAT RELIES 3286 02:37:06,480 --> 02:37:08,600 ON THE AVAILABILITY OF THESE 3287 02:37:08,600 --> 02:37:09,840 GENOMES FOR THEIR RESEARCH. 3288 02:37:09,840 --> 02:37:13,160 IF YOU LOOK AT THE NUMBER OF 3289 02:37:13,160 --> 02:37:14,280 GENOMES THAT ARE AVAILABLE IN 3290 02:37:14,280 --> 02:37:17,560 THE PUBLIC DATABASES IT IS 3291 02:37:17,560 --> 02:37:18,600 RELATIVELY SMALL. 3292 02:37:18,600 --> 02:37:20,720 THE QUALITY IS HIGHLY VARIABLE 3293 02:37:20,720 --> 02:37:21,880 AS WELL. 3294 02:37:21,880 --> 02:37:24,400 SO WE ALWAYS MEASURE ON THE 3295 02:37:24,400 --> 02:37:25,960 NUMBER OF GENES THAT WE CAN 3296 02:37:25,960 --> 02:37:28,080 CONTRIBUTE AND THE IMPACT IN 3297 02:37:28,080 --> 02:37:30,960 TERMS OF HOW MANY PUBLICATIONS 3298 02:37:30,960 --> 02:37:32,720 USE THIS. 3299 02:37:32,720 --> 02:37:39,800 AT THE SAME TIME WE HAVE WANT TO 3300 02:37:39,800 --> 02:37:42,320 ELEVATE TO KNOW HOW MANY PEOPLE 3301 02:37:42,320 --> 02:37:44,080 USE THIS AND WE TRY TO KEEP 3302 02:37:44,080 --> 02:37:45,640 TRACK OF THIS. 3303 02:37:45,640 --> 02:37:47,400 AT THE SAME TIME WE HAVE MANY 3304 02:37:47,400 --> 02:37:50,400 MORE COLLABORATORS WHO WISH TO 3305 02:37:50,400 --> 02:37:55,480 SHARE THEIR DATA WHICH IS AN 3306 02:37:55,480 --> 02:38:05,600 IMPORTANT MEASURE OF SUCCESS. 3307 02:38:05,600 --> 02:38:07,800 >>SO THERE ARE A COUPLE OF MORE 3308 02:38:07,800 --> 02:38:10,400 QUESTIONS IN THE CHAT. 3309 02:38:10,400 --> 02:38:12,440 PERTAINING AGAIN TO IMPACT OF 3310 02:38:12,440 --> 02:38:15,000 SUCCESS AND SPECIFIC METRICS AND 3311 02:38:15,000 --> 02:38:17,040 CHANGES OVER TIME. 3312 02:38:17,040 --> 02:38:20,840 SO CAN YOU -- MAYBE CAN YOU 3313 02:38:20,840 --> 02:38:22,520 SUMMARIZE WHAT IS THE PLAN TO 3314 02:38:22,520 --> 02:38:25,720 COLLECT METRICS AND WHAT METRICS 3315 02:38:25,720 --> 02:38:28,720 DO YOU HAVE AND WHAT CHANGES 3316 02:38:28,720 --> 02:38:32,480 HAVE YOU SEEN IN THE METHOD 3317 02:38:32,480 --> 02:38:41,600 METRICS OVERTIME. 3318 02:38:41,600 --> 02:38:43,440 >>I CAN GO. 3319 02:38:43,440 --> 02:38:51,480 WE DON'T REALLY HAVE SPECIFIC 3320 02:38:51,480 --> 02:38:53,680 METRICS BUT FOR EXAMPLE THERE 3321 02:38:53,680 --> 02:38:57,680 ARE CURRENTLY OVER ELEVEN 3322 02:38:57,680 --> 02:39:03,080 STUDIES THAT HAVE BEGAN TO READ 3323 02:39:03,080 --> 02:39:06,400 OUT THE THE AMOUNT AND WE'RE 3324 02:39:06,400 --> 02:39:08,640 PLANNING TO INCORPORATE AS MANY 3325 02:39:08,640 --> 02:39:11,400 THOSE AS WE CAN AND KEEPING 3326 02:39:11,400 --> 02:39:12,560 TRACK OF ALL OF THE RESEARCH 3327 02:39:12,560 --> 02:39:18,840 THAT IS HAPPENING IN THIS SPACE. 3328 02:39:18,840 --> 02:39:22,840 SO IDEALLY WE WOULD SEE ALL OF 3329 02:39:22,840 --> 02:39:25,720 THOSE TRIALS AND META ANALYZE 3330 02:39:25,720 --> 02:39:27,680 THEM INTO THE PLATFORM. 3331 02:39:27,680 --> 02:39:32,520 IN TERMS OF THE REGULATORY, MORE 3332 02:39:32,520 --> 02:39:37,640 PATIENT CENTERED, I THINK EVEN 3333 02:39:37,640 --> 02:39:39,680 ONE THING THAT WE COULD LOOK AT 3334 02:39:39,680 --> 02:39:41,680 AND WE DON'T HAVE PLANS TO LOOK 3335 02:39:41,680 --> 02:39:47,200 AT THIS -- EVEN IF THERE IS ONE 3336 02:39:47,200 --> 02:39:53,000 TRIAL THAT IS SORT OF OR ONE 3337 02:39:53,000 --> 02:39:54,200 POTENTIAL DRUG THAT IS ALLOWED 3338 02:39:54,200 --> 02:39:58,680 TO BE APPROVED UNDER AN 3339 02:39:58,680 --> 02:40:04,000 ACCELERATED PATHWAY BASED ON 3340 02:40:04,000 --> 02:40:07,720 DATA AND THEN FURTHER DOWN THE 3341 02:40:07,720 --> 02:40:10,320 LINE VALIDATED USING IMPACT ON 3342 02:40:10,320 --> 02:40:12,480 MORTALITY OR OTHER METRICS. 3343 02:40:12,480 --> 02:40:16,120 I THINK THAT IS SOMETHING THAT 3344 02:40:16,120 --> 02:40:19,080 YOU COULD POTENTIALLY MEASURE. 3345 02:40:19,080 --> 02:40:24,160 AND ALSO PRESUMABLY THE AVERAGE 3346 02:40:24,160 --> 02:40:27,240 LENGTH OF A TRIAL COULD GO DOWN 3347 02:40:27,240 --> 02:40:33,240 OVER TIME IN THIS DISEASE SPACE. 3348 02:40:33,240 --> 02:40:39,720 DECREASE THE TIME & THE COST. 3349 02:40:39,720 --> 02:40:47,040 SO THOSE ARE MEASURABLE. 3350 02:40:47,040 --> 02:40:50,880 >>I CAN SHARE SOME FACTS. 3351 02:40:50,880 --> 02:40:54,400 I WAS FURIOUSLY LOOKING FOR HARD 3352 02:40:54,400 --> 02:40:56,400 NUMBERS TO SHARE BUT DIDN'T 3353 02:40:56,400 --> 02:40:57,880 CATCH ANY OF THOSE YET. 3354 02:40:57,880 --> 02:41:00,960 BUT I CAN SHARE SOME THOUGHTS. 3355 02:41:00,960 --> 02:41:02,240 BECAUSE WE ARE HOPING THAT 3356 02:41:02,240 --> 02:41:05,400 PEOPLE WILL REUSE OUR RESOURCES. 3357 02:41:05,400 --> 02:41:08,640 WE HAVE GOOGLE ANALYTICS IN 3358 02:41:08,640 --> 02:41:10,480 PLACE IN ORDER TO SEE ACCESS TO 3359 02:41:10,480 --> 02:41:12,160 THE RESOURCES. 3360 02:41:12,160 --> 02:41:14,640 AND TIME THAT PEOPLE REMAIN AND 3361 02:41:14,640 --> 02:41:16,720 DOWNLOADS AND ALL OF THESE 3362 02:41:16,720 --> 02:41:17,120 THINGS. 3363 02:41:17,120 --> 02:41:21,960 WE HAVE STATISTICS FOR APIs. 3364 02:41:21,960 --> 02:41:26,000 THERE IS ALSO THE PART IN WHICH 3365 02:41:26,000 --> 02:41:28,200 THE COMMUNITY PROVIDES WELL 3366 02:41:28,200 --> 02:41:30,000 FIRST WE HAVE THE ABILITY TO 3367 02:41:30,000 --> 02:41:33,840 COME TOGETHER. 3368 02:41:33,840 --> 02:41:37,040 FOR SPECIFIC TOPIC PANELS. 3369 02:41:37,040 --> 02:41:41,080 SO FOR THE HUMAN PHENOTYPE AN TO 3370 02:41:41,080 --> 02:41:46,720 THE GEE WE HELD A * WORKSHOP AT 3371 02:41:46,720 --> 02:41:49,400 NIH'S OFFICES AND WE WERE ABLE 3372 02:41:49,400 --> 02:41:51,840 TO GATHER A COMMUNITY OF ABOUT 3373 02:41:51,840 --> 02:41:52,960 30 PEOPLE FROM ACROSS THE 3374 02:41:52,960 --> 02:42:01,640 COUNTRY. 3375 02:42:01,640 --> 02:42:02,880 AND WE ALL CAME TOGETHER IN 3376 02:42:02,880 --> 02:42:05,760 ORDER TO EXPAND THE TERMS FOR 3377 02:42:05,760 --> 02:42:09,320 THE PARTICULAR BRANCH OF THE 3378 02:42:09,320 --> 02:42:10,880 ONTOLOGY THAT DEALS WITH MENTAL 3379 02:42:10,880 --> 02:42:15,080 HEALTH IN TERMS OF BI-POLAR 3380 02:42:15,080 --> 02:42:16,920 DISORDER, AUTISM. 3381 02:42:16,920 --> 02:42:18,600 WE KNOW NOW THAT WE HAVE BEEN 3382 02:42:18,600 --> 02:42:24,000 ABLE TO IMPROVE ON UPWARDS OF 3383 02:42:24,000 --> 02:42:26,440 150 TERMS DESCRIBING AUTISM 3384 02:42:26,440 --> 02:42:29,880 SPECIFICALLY WITH THE HUMAN 3385 02:42:29,880 --> 02:42:33,040 PHENOTYPE ONTOLOGY. 3386 02:42:33,040 --> 02:42:34,920 WE'VE BEEN ABLE TO CAPTURE 3387 02:42:34,920 --> 02:42:37,360 UPWARDS OF A THOUSAND UPDATES TO 3388 02:42:37,360 --> 02:42:39,800 TERMS. 3389 02:42:39,800 --> 02:42:44,160 UPDATES TO TEXTURAL. 3390 02:42:44,160 --> 02:42:46,720 SO WE KNOW THAT THOSE NUMBERS 3391 02:42:46,720 --> 02:42:50,200 ALLOW US TO SEE THE COMMUNITIES 3392 02:42:50,200 --> 02:42:51,880 ARE CONSUMING AND PROVIDING 3393 02:42:51,880 --> 02:42:52,280 FEEDBACK. 3394 02:42:52,280 --> 02:42:55,160 SO WE USUALLY PRESENT TABLES 3395 02:42:55,160 --> 02:42:56,960 THAT I DON'T HAVE THAT ALLOW US 3396 02:42:56,960 --> 02:42:59,320 TO SEE HOW WELL OUR RESOURCES 3397 02:42:59,320 --> 02:43:01,320 ARE BEING ENGAGED WITH AND WHAT 3398 02:43:01,320 --> 02:43:02,920 KIND OF FEEDBACK WE RECEIVE FROM 3399 02:43:02,920 --> 02:43:04,320 THE COMMUNITY. 3400 02:43:04,320 --> 02:43:08,160 WE USE THAT AS A MEASURE OF OUR 3401 02:43:08,160 --> 02:43:09,000 SUCCESS. 3402 02:43:09,000 --> 02:43:11,320 >>LET ME JUST SAY BRIEFLY THAT 3403 02:43:11,320 --> 02:43:14,080 THERE IS SOMETHING CALLED THE 3404 02:43:14,080 --> 02:43:16,760 EARTH -- PROJECT THAT COLLECTS 3405 02:43:16,760 --> 02:43:21,680 ALL OF THESE PROJECTS. 3406 02:43:21,680 --> 02:43:24,320 WE ARE THE SECOND LARGEST 3407 02:43:24,320 --> 02:43:26,680 CONTRIBUTOR OF REFERENCE GENOMES 3408 02:43:26,680 --> 02:43:29,400 AND THE FIRST ONE FOR -- THAT IS 3409 02:43:29,400 --> 02:43:39,800 A MEASURE OF SUCCESS. 3410 02:43:40,560 --> 02:43:45,520 >>THANK YOU. 3411 02:43:45,520 --> 02:43:52,280 ANOTHER QUESTION FROM SLIDO IS 3412 02:43:52,280 --> 02:43:55,680 -- HOW DO YOU LEARN ABOUT THE 3413 02:43:55,680 --> 02:44:01,000 PRIZE AND DID THE PRIZE OR 3414 02:44:01,000 --> 02:44:03,480 INCENTIVE FOR DATA REUSE SUPPORT 3415 02:44:03,480 --> 02:44:04,720 YOUR WORK? 3416 02:44:04,720 --> 02:44:08,360 LET'S GO OPPOSITE ORDER. 3417 02:44:08,360 --> 02:44:09,360 >>I'LL START. 3418 02:44:09,360 --> 02:44:12,880 WELL HONESTLY WE LEARNED ABOUT 3419 02:44:12,880 --> 02:44:16,200 THE PRIZE IN A WEEKLY DIGEST 3420 02:44:16,200 --> 02:44:19,760 FROM OUR INSTITUTION DEALING 3421 02:44:19,760 --> 02:44:21,720 WITH OPPORTUNITIES FOR GRANTS. 3422 02:44:21,720 --> 02:44:27,080 I GUESS THAT IS GOOD. 3423 02:44:27,080 --> 02:44:29,960 THERE IS A STRONG MOTIVATIONAL 3424 02:44:29,960 --> 02:44:31,280 COMPONENT ESPECIALLY WHEN IT 3425 02:44:31,280 --> 02:44:32,960 COMES TO MAKE DATA PUBLIC. 3426 02:44:32,960 --> 02:44:36,040 AND WE'RE TALKING ABOUT ENTIRELY 3427 02:44:36,040 --> 02:44:37,720 NOVEL DATA. 3428 02:44:37,720 --> 02:44:38,920 TALKING ABOUT SOMETHING THAT 3429 02:44:38,920 --> 02:44:40,800 WE'VE AGAIN SEPARATED WITH OUR 3430 02:44:40,800 --> 02:44:43,480 OWN HANDS COLLECTIVELY IN THE 3431 02:44:43,480 --> 02:44:45,600 PUBLIC SO MAKING IT ENTIRELY 3432 02:44:45,600 --> 02:44:48,680 PUBLIC WAS A VERY GOOD DECISION 3433 02:44:48,680 --> 02:44:50,080 IN THE FIRST PLACE. 3434 02:44:50,080 --> 02:44:51,800 AND NOT EVERYBODY WAS ON-BOARD 3435 02:44:51,800 --> 02:44:54,720 WITH THAT. 3436 02:44:54,720 --> 02:44:57,240 BECAUSE WE ARE DOING SCIENCE. 3437 02:44:57,240 --> 02:44:59,640 SO THERE IS ALWAYS A RISK' 3438 02:44:59,640 --> 02:45:02,880 SHARING AND TWIRLING. 3439 02:45:02,880 --> 02:45:05,080 SO RECEIVING THIS KIND OF PRIZE 3440 02:45:05,080 --> 02:45:07,920 THAT PROMOTES DATA REUSE AND SO 3441 02:45:07,920 --> 02:45:14,160 FORTH IT'S A VERY GOOD INCENTIVE 3442 02:45:14,160 --> 02:45:16,200 AND IDEA AND THE SOONER THE DATA 3443 02:45:16,200 --> 02:45:18,640 BECOMES PUBLIC AND THE SOONER IT 3444 02:45:18,640 --> 02:45:20,320 BECOMES EASY FOR REUSE THE 3445 02:45:20,320 --> 02:45:30,440 BETTER. 3446 02:45:31,320 --> 02:45:35,760 >>IN TERMS OF HOW WE FOUND OUT 3447 02:45:35,760 --> 02:45:40,360 I BELIEVE OUR COLLABORATORS FROM 3448 02:45:40,360 --> 02:45:43,120 ARC ARE THE ONES THAT TOLD US 3449 02:45:43,120 --> 02:45:46,440 ABOUT THIS PRIZE. 3450 02:45:46,440 --> 02:45:46,840 CHALLENGE. 3451 02:45:46,840 --> 02:45:49,400 SO I DON'T KNOW HOW THEY FOUND 3452 02:45:49,400 --> 02:45:50,000 OUT ABOUT IT. 3453 02:45:50,000 --> 02:45:54,880 BUT I'M SURE THEY ARE -- THEY 3454 02:45:54,880 --> 02:45:57,080 ARE ON ALL SORTS OF E-MAIL 3455 02:45:57,080 --> 02:46:02,120 LISTS. 3456 02:46:02,120 --> 02:46:05,960 IN TERMS OF INCENTIVES I WOULD 3457 02:46:05,960 --> 02:46:08,400 ECHO WHAT GIULIO SAID, 3458 02:46:08,400 --> 02:46:12,080 ESSENTIALLY WE ARE NOW THINKING 3459 02:46:12,080 --> 02:46:21,280 MUCH MORE ABOUT HOW CAN WE TURN 3460 02:46:21,280 --> 02:46:24,920 OUR FEDERATED ANALYTICS INTO A 3461 02:46:24,920 --> 02:46:28,680 PLATFORM THAT CAN BE EASILY USED 3462 02:46:28,680 --> 02:46:29,920 AND MORE PUBLIC. 3463 02:46:29,920 --> 02:46:32,320 THERE ARE CHALLENGES GIVEN THE 3464 02:46:32,320 --> 02:46:33,680 INSTITUTIONAL FRAMEWORK THAT WE 3465 02:46:33,680 --> 02:46:34,640 WORK IN. 3466 02:46:34,640 --> 02:46:39,240 BUT I THINK IT'S REALLY KIND OF 3467 02:46:39,240 --> 02:46:44,960 -- IT HELPED US THINK MORE ABOUT 3468 02:46:44,960 --> 02:46:48,360 REALLY SHARING IT MORE BROADLY. 3469 02:46:48,360 --> 02:46:51,960 AND MAKING MORE AVAILABLE TO 3470 02:46:51,960 --> 02:46:53,440 OTHER RESEARCHERS AND OTHER 3471 02:46:53,440 --> 02:46:57,400 INSTITUTIONS. 3472 02:46:57,400 --> 02:47:00,200 THAT. MONICA, GO AHEAD. 3473 02:47:00,200 --> 02:47:03,720 >>ALL OF OUR RESOURCES DATA, 3474 02:47:03,720 --> 02:47:06,200 ONTOLOGIES, STANDARDS, SOFTWARE 3475 02:47:06,200 --> 02:47:08,840 TOOLS, ALGORITHMS, WE GENERATE 3476 02:47:08,840 --> 02:47:13,520 -- IT'S ALREADY OPEN SOURCE. 3477 02:47:13,520 --> 02:47:16,640 AND WE -- I THINK I'M GOING 3478 02:47:16,640 --> 02:47:17,440 BACKWARDS. 3479 02:47:17,440 --> 02:47:20,960 WHAT HAS INCENTIVIZED FOR US IS 3480 02:47:20,960 --> 02:47:22,760 THE CONTINUATION OF BETTER THE 3481 02:47:22,760 --> 02:47:23,880 FIND. 3482 02:47:23,880 --> 02:47:25,960 WHAT MAKES THINGS FAIR AND 3483 02:47:25,960 --> 02:47:28,000 TRUSTWORTHY AND IT'S CHALLENGING 3484 02:47:28,000 --> 02:47:31,640 BECAUSE EXECUTING THAT VISION 3485 02:47:31,640 --> 02:47:33,600 HAS ITS ROCKS IN THE ROAD. 3486 02:47:33,600 --> 02:47:38,440 SO WE CREATED A ROADWAY TO 3487 02:47:38,440 --> 02:47:41,040 OPERATE RACIAL EYES * AND ACCESS 3488 02:47:41,040 --> 02:47:43,560 AND FINDING AND INTERPRETATION 3489 02:47:43,560 --> 02:47:47,520 AND REUSE THERE IS THE NEED TO 3490 02:47:47,520 --> 02:47:49,280 TRACE WHERE THE DATA CAME FROM 3491 02:47:49,280 --> 02:47:51,880 TO USE THE DATA FREELY WITHOUT 3492 02:47:51,880 --> 02:47:54,480 LICENSING. 3493 02:47:54,480 --> 02:47:57,320 SO WE WORK REALLY HARD TO GO 3494 02:47:57,320 --> 02:47:59,920 BEYOND JUST THE FAIR AND 3495 02:47:59,920 --> 02:48:02,240 TRUSTWORTHY TO MAKE SURE THAT 3496 02:48:02,240 --> 02:48:03,920 THINGS ARE AVAILABLE TO ALL OF 3497 02:48:03,920 --> 02:48:05,120 THE COMMUNITY. 3498 02:48:05,120 --> 02:48:08,080 SO, THAT IS KIND OF LIKE WHERE 3499 02:48:08,080 --> 02:48:10,760 IT INCENTIVIZES US TO MOVE 3500 02:48:10,760 --> 02:48:11,400 FURTHER. 3501 02:48:11,400 --> 02:48:17,440 WHERE WE LEARNED ABOUT THIS -- 3502 02:48:17,440 --> 02:48:19,480 IT'S PROBABLY WE ARE ON A COUPLE 3503 02:48:19,480 --> 02:48:21,120 OF DOZEN LISTS FROM NIH AND I 3504 02:48:21,120 --> 02:48:23,240 KNOW IT WAS EITHER SOMETHING 3505 02:48:23,240 --> 02:48:24,560 THAT CAME FROM THE OFFICE OF 3506 02:48:24,560 --> 02:48:29,720 DATA SCIENCE OR PHASE B OR 3507 02:48:29,720 --> 02:48:32,560 SOMETHING ALONG THOSE LINES AND 3508 02:48:32,560 --> 02:48:34,320 WE JUMPED AT THE OPPORTUNITY TO 3509 02:48:34,320 --> 02:48:35,560 BE ABLE TO APPLY 3510 02:48:35,560 --> 02:48:36,640 >>THANK YOU SO MUCH. 3511 02:48:36,640 --> 02:48:38,800 THANK YOU ALL OF YOU FORGIVING 3512 02:48:38,800 --> 02:48:42,880 US A GREAT OVERVIEW OF YOUR WORK 3513 02:48:42,880 --> 02:48:47,280 AND NOW WE'LL HAND IT OFF TO 3514 02:48:47,280 --> 02:48:49,600 PARKER ANTIN FOR THE NEXT PANEL. 3515 02:48:49,600 --> 02:48:52,840 THANK YOU AGAIN. 3516 02:48:52,840 --> 02:48:54,080 >>THANKS VERY MUCH. 3517 02:48:54,080 --> 02:48:58,520 MY NAME IS PARKER ANTIN. 3518 02:48:58,520 --> 02:49:00,440 FROM THE UNIVERSITY OF ARIZONA 3519 02:49:00,440 --> 02:49:09,160 AND PAST PRESIDENT OF FAS EB AND 3520 02:49:09,160 --> 02:49:11,760 WE HAVE TWO PANELISTS AND THEY 3521 02:49:11,760 --> 02:49:13,160 WILL HAVE BRIEF PRESENTATIONS 3522 02:49:13,160 --> 02:49:15,240 AND THEN WE'LL MOVE TO PANEL 3523 02:49:15,240 --> 02:49:15,680 DISCUSSION. 3524 02:49:15,680 --> 02:49:18,240 I WANT TO REMIND YOU THAT IF 3525 02:49:18,240 --> 02:49:21,240 YOU'RE NOT ABLE TO ACCESS THE 3526 02:49:21,240 --> 02:49:23,120 VIDEO CHAT THE CHAT FUNCTION ON 3527 02:49:23,120 --> 02:49:27,760 ZOOM IF YOU'RE ON THE NIH VIDEO 3528 02:49:27,760 --> 02:49:30,640 CAST YOU CAN GO IS TO SLIDO .COM 3529 02:49:30,640 --> 02:49:35,520 AND ENTER THE NUMBER 1379 TO SEE 3530 02:49:35,520 --> 02:49:37,600 THE CHAT THERE AND ENTER ANY 3531 02:49:37,600 --> 02:49:39,200 QUESTIONS. 3532 02:49:39,200 --> 02:49:45,400 I'M PLEASED TO INTRODUCE OUR TWO 3533 02:49:45,400 --> 02:49:51,200 PANELISTS GEORGIO AS SLOWLY AND 3534 02:49:51,200 --> 02:49:54,600 EUN-YOUNG MUN. 3535 02:49:54,600 --> 02:49:59,160 FIRST UP IS GEORGIO. 3536 02:49:59,160 --> 02:50:02,360 A PROFESSOR AT GEORGE MASON 3537 02:50:02,360 --> 02:50:06,400 UNIVERSITY. 3538 02:50:06,400 --> 02:50:09,720 PLEASE GO AHEAD. 3539 02:50:09,720 --> 02:50:11,600 >>THANK YOU VERY MUCH. 3540 02:50:11,600 --> 02:50:13,440 CAN YOU HEAR ME FINE? 3541 02:50:13,440 --> 02:50:15,480 I'M GOING TO SHARE MY SCREEN AND 3542 02:50:15,480 --> 02:50:25,840 SEE IF THAT WORKS TOO. 3543 02:50:29,240 --> 02:50:30,840 IT'S A GREAT PLEASURE AND 3544 02:50:30,840 --> 02:50:33,240 PRIVILEGE TO BE HERE TODAY TO 3545 02:50:33,240 --> 02:50:35,240 SPEAK. 3546 02:50:35,240 --> 02:50:37,720 FROM GEORGE MASON UNIVERSITY. 3547 02:50:37,720 --> 02:50:39,960 AND OUR PROJECT TITLE IS THE 3548 02:50:39,960 --> 02:50:45,480 PUBLIC REPOSITORY OF NEURAL 3549 02:50:45,480 --> 02:50:46,680 MORPHOLOGY. 3550 02:50:46,680 --> 02:50:50,120 HOW DATA SHARING BENEFITS USERS 3551 02:50:50,120 --> 02:50:53,320 AND PRODUCERS BECAUSE THIS HAS 3552 02:50:53,320 --> 02:50:55,320 BEEN VERY NEAR AND DEAR TO MY 3553 02:50:55,320 --> 02:50:59,600 HEART FOR MANY YEARS. 3554 02:50:59,600 --> 02:51:02,120 MY TEAM MEMBERS WHO HAVE FUELED 3555 02:51:02,120 --> 02:51:05,240 AND FOSTERED MUCH OF THE 3556 02:51:05,240 --> 02:51:06,800 RESOURCE THAT I WILL HIGHLIGHT 3557 02:51:06,800 --> 02:51:09,720 IN THE NEXT TWO MINUTES. 3558 02:51:09,720 --> 02:51:15,680 SO THIS IS A DATABASE. 3559 02:51:15,680 --> 02:51:26,000 NEURO MORE GO.ORG. 3560 02:51:32,080 --> 02:51:34,440 THIS FORMS THE GIGANTIC NETWORK 3561 02:51:34,440 --> 02:51:36,800 THAT IS THE BRAIN BUT ALSO THE 3562 02:51:36,800 --> 02:51:39,480 SAME TREES ALLOW THE NERVE CELLS 3563 02:51:39,480 --> 02:51:40,800 TO INTEGRATE INFORMATION THAT 3564 02:51:40,800 --> 02:51:42,600 THEY RECEIVE FROM OTHER NEURONS 3565 02:51:42,600 --> 02:51:45,040 AS WELL AS TRANSMIT THAT 3566 02:51:45,040 --> 02:51:46,600 INFORMATION BRAIN WIDE TO ALL OF 3567 02:51:46,600 --> 02:51:48,120 THE OTHER NERVE CELLS. 3568 02:51:48,120 --> 02:51:52,640 AND FOR THE GLEE A THAT TREE 3569 02:51:52,640 --> 02:51:55,440 SHAPE ALLOWS THEM TO PERFORM THE 3570 02:51:55,440 --> 02:51:57,360 VITAL SUPPORT FUNCTIONS THAT 3571 02:51:57,360 --> 02:51:59,600 THESE CELLS ARE TASKED FOR 3572 02:51:59,600 --> 02:52:04,400 INCLUDING FORMATION OF MY LINA 3573 02:52:04,400 --> 02:52:09,480 ROUND THE ASK ONS OF NEURON AND 3574 02:52:09,480 --> 02:52:16,040 IMMUNE REACTION FROM TRAUMA ETC. 3575 02:52:16,040 --> 02:52:20,560 NEURO MORPHO.ORG STARTED IN 3576 02:52:20,560 --> 02:52:24,760 2006. 3577 02:52:24,760 --> 02:52:29,520 TO SHARE DATA TO TRANSLATE IN A 3578 02:52:29,520 --> 02:52:31,840 COMMON FORMAT AND POST IT 3579 02:52:31,840 --> 02:52:34,800 ON-LINE FOR PUBLIC FREE REUSE 3580 02:52:34,800 --> 02:52:39,640 AND ALONG THE WAY WE ADDED MANY 3581 02:52:39,640 --> 02:52:41,800 FUNCTIONALITY TO THIS RESOURCE 3582 02:52:41,800 --> 02:52:44,000 AND DOCUMENTED THEM IN 3583 02:52:44,000 --> 02:52:45,640 SUBSEQUENT PUBLICATIONS. 3584 02:52:45,640 --> 02:52:48,480 TODAY USERS CAN ACCESS THROUGH A 3585 02:52:48,480 --> 02:52:50,600 SIMPLE WEB PAGE THROUGH ANY 3586 02:52:50,600 --> 02:52:53,560 BROWSER AND THEY CAN BROWSE THE 3587 02:52:53,560 --> 02:52:56,440 DATA UNDER MAIN CATEGORIES SUCH 3588 02:52:56,440 --> 02:53:00,320 AS THE ANATOMICAL REGIONS, CELL 3589 02:53:00,320 --> 02:53:04,360 TYPES AND ARCHIVES WHICH ARE THE 3590 02:53:04,360 --> 02:53:06,760 SOURCES THAT SHARE THE DATA AND 3591 02:53:06,760 --> 02:53:09,040 WITHIN EACH OF THOSE CATEGORIES 3592 02:53:09,040 --> 02:53:11,600 THE DISTRIBUTION OF THE DATA IS 3593 02:53:11,600 --> 02:53:12,680 FAIRLY EVEN. 3594 02:53:12,680 --> 02:53:14,880 THE BULK OF THE DATA COMES FROM 3595 02:53:14,880 --> 02:53:15,520 THE MOUSE. 3596 02:53:15,520 --> 02:53:18,080 BUT MORE THAN 90 DIFFERENT 3597 02:53:18,080 --> 02:53:20,720 SPECIES ARE REPRESENTED. 3598 02:53:20,720 --> 02:53:24,360 AND LIKEWISE NEOCORTEX -- IS 3599 02:53:24,360 --> 02:53:26,480 VERY MUCH STUDIED AND THIS IS 3600 02:53:26,480 --> 02:53:29,760 REFLECTED IN THE AMOUNT OF DATA 3601 02:53:29,760 --> 02:53:31,320 THAT WE HAVE AVAILABLE IN THE 3602 02:53:31,320 --> 02:53:31,920 REPOSITORY. 3603 02:53:31,920 --> 02:53:33,880 AND EVEN FOR THE CELL TYPES. 3604 02:53:33,880 --> 02:53:36,200 THAT IS THE CASE. 3605 02:53:36,200 --> 02:53:39,320 THERE IS AN EVEN DISTRIBUTION. 3606 02:53:39,320 --> 02:53:41,000 DATA CAN BE BROWSED THROUGH 3607 02:53:41,000 --> 02:53:42,320 SIMPLE INTERFACES. 3608 02:53:42,320 --> 02:53:44,200 THEY CAN ALSO BE SEARCHED AND 3609 02:53:44,200 --> 02:53:46,320 ONCE YOU LAND ON A PARTICULAR 3610 02:53:46,320 --> 02:53:48,440 PIECE OF DATA OF INTEREST GIVEN 3611 02:53:48,440 --> 02:53:50,920 THE RECONSTRUCTION OF THE GIVEN 3612 02:53:50,920 --> 02:53:52,880 CELL WHAT USERS HAVE IMMEDIATE 3613 02:53:52,880 --> 02:53:55,240 ACCESS TO IS THE ACTUAL FILE 3614 02:53:55,240 --> 02:53:59,280 THAT WE CALL THAT THE SWC FILE. 3615 02:53:59,280 --> 02:54:02,560 AN AS KEY FILE THAT PROVIDES A 3616 02:54:02,560 --> 02:54:07,600 THREE DIMENSION, COORDINATE. 3617 02:54:07,600 --> 02:54:09,600 AND THAT FILE IS WHAT ALLOWS 3618 02:54:09,600 --> 02:54:13,440 PEOPLE TO DO SECONDARY ANALYSIS. 3619 02:54:13,440 --> 02:54:14,800 ILLUSTRATIONS BUT ALSO 3620 02:54:14,800 --> 02:54:17,320 SIMULATIONS OF BIOPHYSICAL DATA 3621 02:54:17,320 --> 02:54:22,000 AND CONNECTIVITY AND SO FORTH. 3622 02:54:22,000 --> 02:54:24,560 IN ADDITION WE ALSO ANNOTATE 3623 02:54:24,560 --> 02:54:29,200 EACH OF THE DATA WITH EXTENSIVE 3624 02:54:29,200 --> 02:54:30,680 METADATA THAT INCLUDES THE 3625 02:54:30,680 --> 02:54:33,520 PROVIDENCE OF THE DATA, THE 3626 02:54:33,520 --> 02:54:35,720 EXPERIMENTAL METHODS AND THE 3627 02:54:35,720 --> 02:54:37,880 GRAPHIC INFORMATION OFF THE 3628 02:54:37,880 --> 02:54:39,440 ORIGINAL PAPERS WHERE THE DATA 3629 02:54:39,440 --> 02:54:42,760 WAS FIRST DESCRIBED AND WE 3630 02:54:42,760 --> 02:54:44,960 PRECOMPUTE A STANDARD SET OF 3631 02:54:44,960 --> 02:54:45,720 MEASUREMENTS. 3632 02:54:45,720 --> 02:54:48,040 THE REASON THAT WE DO SUCH 3633 02:54:48,040 --> 02:54:49,960 EXTENSIVE ANNOTATION IS NOT ONLY 3634 02:54:49,960 --> 02:54:52,400 TO ENRICH THE DATA BUT ALLOW 3635 02:54:52,400 --> 02:54:58,240 USERS TO FIND DATA OF INTEREST 3636 02:54:58,240 --> 02:55:00,520 BECAUSE ANY OF THE THESE ENTRIES 3637 02:55:00,520 --> 02:55:03,160 CAN THEN BE USED IN THE SEARCH 3638 02:55:03,160 --> 02:55:04,080 ENGINE. 3639 02:55:04,080 --> 02:55:06,360 IMPORTANTLY EACH IS NOT ONLY 3640 02:55:06,360 --> 02:55:08,520 ACCESSIBLE BY HUMANS THROUGH 3641 02:55:08,520 --> 02:55:11,280 DROP DOWN MENUS AND SO FORTH BUT 3642 02:55:11,280 --> 02:55:15,360 ALSO BY MACHINES THROUGH AN 3643 02:55:15,360 --> 02:55:17,680 INTERFACE THAT CAN ALSO INQUIRY 3644 02:55:17,680 --> 02:55:20,200 THE DATA. 3645 02:55:20,200 --> 02:55:23,720 WE ALSO HAVE EXTENSIVE COVERAGE 3646 02:55:23,720 --> 02:55:25,600 OF THE LITERATURE NOT ONLY 3647 02:55:25,600 --> 02:55:27,920 REGARDING THE DATA THEMSELVES, 3648 02:55:27,920 --> 02:55:29,800 ALL OF THE DATA IS ANNOTATED IN 3649 02:55:29,800 --> 02:55:33,280 THE DATABASE. 3650 02:55:33,280 --> 02:55:36,480 ANY DATA THAT WE IDENTIFY EVEN 3651 02:55:36,480 --> 02:55:39,960 IF THE AUTHORS DO NOT RESPOND TO 3652 02:55:39,960 --> 02:55:42,520 OUR INVITATION OR DECLINE OUR 3653 02:55:42,520 --> 02:55:45,280 INVITATION TO SUBMIT THE DATA. 3654 02:55:45,280 --> 02:55:47,520 WE TRACK USAGE OF THE DATA SO 3655 02:55:47,520 --> 02:55:50,040 WHEN PEOPLE DOWNLOAD AND USE IT 3656 02:55:50,040 --> 02:55:52,000 IN SECONDARY PUBLICATIONS WE 3657 02:55:52,000 --> 02:55:53,720 TRACK THAT AS WELL. 3658 02:55:53,720 --> 02:55:56,240 AS AN EXAMPLE OF THE DATABASE 3659 02:55:56,240 --> 02:55:58,400 REGARDING THE LITERATURE 3660 02:55:58,400 --> 02:56:01,640 CONTAINS IDENTIFIERS SUCH AS 3661 02:56:01,640 --> 02:56:03,680 PubMed AS WELL AS THE AUTHORS 3662 02:56:03,680 --> 02:56:06,040 AND THE STATUS OF THEIR REQUEST. 3663 02:56:06,040 --> 02:56:07,840 WHETHER THEIR RESPONSE WAS 3664 02:56:07,840 --> 02:56:09,680 RECEIVED AND WHETHER THE DATA 3665 02:56:09,680 --> 02:56:12,280 WAS INCLUDED OR NOT AND WE HAVE 3666 02:56:12,280 --> 02:56:15,160 A FINITE AMOUNT OF LITERATURE 3667 02:56:15,160 --> 02:56:17,720 BECAUSE THE TECHNOLOGY DATES 3668 02:56:17,720 --> 02:56:22,200 BACK TO WHEN MICROSCOPES WERE 3669 02:56:22,200 --> 02:56:24,720 INTERFACED WITH COMPUTERS ABOUT 3670 02:56:24,720 --> 02:56:32,120 40 YEARS AGO. 3671 02:56:32,120 --> 02:56:40,360 THE RATE OF ACCUMULATION IS 3672 02:56:40,360 --> 02:56:45,080 INCREASING. 3673 02:56:45,080 --> 02:56:47,840 THE FIRST HALF OF THE LIFE OF 3674 02:56:47,840 --> 02:56:52,920 THE DATABASE 8 COMPLETE YEARS 3675 02:56:52,920 --> 02:57:00,000 WERE KIND OF A FLAT LINE. 3676 02:57:00,000 --> 02:57:02,560 AND THEN IT PICKED UP. 3677 02:57:02,560 --> 02:57:04,440 IF YOU LOOKING AT THE RATE OF 3678 02:57:04,440 --> 02:57:08,640 DATA ACCUMULATION THERE IS A 24 3679 02:57:08,640 --> 02:57:12,240 FOLD ACCELERATION FROM ABOUT A 3680 02:57:12,240 --> 02:57:14,400 THOUSAND TO ABOUT 30,000 PER 3681 02:57:14,400 --> 02:57:16,040 YEAR. 3682 02:57:16,040 --> 02:57:18,600 SO WE INVESTIGATED WHAT FACTORS 3683 02:57:18,600 --> 02:57:20,480 CONTRIBUTED TO THAT 3684 02:57:20,480 --> 02:57:21,840 ACCELERATION. 3685 02:57:21,840 --> 02:57:23,720 THIS IS A LITTLE GLANCE ON 3686 02:57:23,720 --> 02:57:24,960 SOMETHING THAT IS REPRESENTATIVE 3687 02:57:24,960 --> 02:57:27,480 OF BIOMEDICAL DATA AT LARGE. 3688 02:57:27,480 --> 02:57:29,960 ONE IS THAT THE NUMBER OF PEER 3689 02:57:29,960 --> 02:57:34,680 REVIEWED PUBLICATION INCREASED 3690 02:57:34,680 --> 02:57:36,320 FROM 120 PER YEAR TO 300. 3691 02:57:36,320 --> 02:57:38,560 SO, THAT IS A TWO AND A HALF 3692 02:57:38,560 --> 02:57:39,560 FOLD FACTOR. 3693 02:57:39,560 --> 02:57:42,240 THE SECOND IS THE AVERAGE 3694 02:57:42,240 --> 02:57:47,080 DATASET SIZE INCREASED DUE TO 3695 02:57:47,080 --> 02:57:48,080 TECHNOLOGICAL DEVELOPMENT BUT 3696 02:57:48,080 --> 02:57:50,800 ALSO INCREASING PRESSURE FROM 3697 02:57:50,800 --> 02:57:52,680 THE PEER COMMUNITY BECAUSE 3698 02:57:52,680 --> 02:57:54,960 REVIEWERS ARE BECOMING MORE 3699 02:57:54,960 --> 02:57:56,760 DEMANDING AS TO HOW MUCH DATA IS 3700 02:57:56,760 --> 02:57:58,800 NEEDED. 3701 02:57:58,800 --> 02:58:01,760 BUT THE GREATEST FACTOR OF ALL 3702 02:58:01,760 --> 02:58:04,160 IS THE ATTITUDE TOWARD DATA 3703 02:58:04,160 --> 02:58:08,320 SHARING HAS PLEASANTLY CHANGED. 3704 02:58:08,320 --> 02:58:10,440 ABOUT FOUR IN FIVE AUTHORS THAT 3705 02:58:10,440 --> 02:58:12,800 WE WOULD CONTACT WOULD EITHER 3706 02:58:12,800 --> 02:58:15,040 NOT RESPOND OR DECLINE TO SHARE 3707 02:58:15,040 --> 02:58:17,920 DATA WHEREAS IN THE PAST SEVERAL 3708 02:58:17,920 --> 02:58:19,160 YEARS THAT PERSONAL HAS 3709 02:58:19,160 --> 02:58:21,080 INCREASED TO A VERY CLEAR AND 3710 02:58:21,080 --> 02:58:22,360 SIGNIFICANT MAJORITY. 3711 02:58:22,360 --> 02:58:23,880 SO WHEN YOU COMBINE THEM ALL 3712 02:58:23,880 --> 02:58:26,040 THIS IS ACTUALLY WHERE THIS 3713 02:58:26,040 --> 02:58:29,640 CURVE IT IS COMING FROM. 3714 02:58:29,640 --> 02:58:31,320 IMPORTANTLY COMBINING THIS ALSO 3715 02:58:31,320 --> 02:58:34,960 MEANS THAT A FEW YEARS AGO IN 3716 02:58:34,960 --> 02:58:37,760 2019 WE PASSED AN IMPORTANT 3717 02:58:37,760 --> 02:58:40,560 LANDMARK WHICH IS MORE THAN 50% 3718 02:58:40,560 --> 02:58:44,600 OF THE DATA PRODUCED WORLDWIDE 3719 02:58:44,600 --> 02:58:52,880 IS ACTUALLY PUBLICLY AVAILABLE. 3720 02:58:52,880 --> 02:58:56,000 AND ANOTHER FACTOR TO THE 3721 02:58:56,000 --> 02:58:58,560 QUANTITY OF THE DATA IS THE 3722 02:58:58,560 --> 02:59:00,840 FOCUS OF THE DATA FOR THE FIRST 3723 02:59:00,840 --> 02:59:02,880 8 YEARS MUCH OF THE 3724 02:59:02,880 --> 02:59:07,120 CONCENTRATION OF RESEARCHERS WAS 3725 02:59:07,120 --> 02:59:07,680 DENDRITE. 3726 02:59:07,680 --> 02:59:11,240 BUT THOSE ARE ALSO THE SMALLER 3727 02:59:11,240 --> 02:59:12,080 ARBOR. 3728 02:59:12,080 --> 02:59:15,280 WHEREAS IN RECENT TIMES THE 3729 02:59:15,280 --> 02:59:17,400 TECHNOLOGY AND SCIENTIFIC 3730 02:59:17,400 --> 02:59:23,240 INTEREST HAS SHIFTED TO THE OX 3731 02:59:23,240 --> 02:59:29,480 AXE COMESOF THE CELLS. 3732 02:59:29,480 --> 02:59:38,520 * SO IT'S NOT JUST THAT MUCH 3733 02:59:38,520 --> 02:59:41,680 MORE DATA ARE BECOMING AVAILABLE 3734 02:59:41,680 --> 02:59:44,400 BUT A MUCH RICHTER TYPE OF DATA. 3735 02:59:44,400 --> 02:59:51,160 OF NOTE ALSO IN 2017 WE ADDED 3736 02:59:51,160 --> 02:59:51,880 GLIA. 3737 02:59:51,880 --> 02:59:54,240 IT WAS A LATE INTEREST IN THE 3738 02:59:54,240 --> 02:59:55,320 FIELD BUT VERY IMPORTANT 3739 02:59:55,320 --> 02:59:58,440 ESPECIALLY FOR DISEASE BECAUSE 3740 02:59:58,440 --> 03:00:00,880 MOST OF THE DISEASES CORRELATE 3741 03:00:00,880 --> 03:00:05,280 WITH CHANGES IN GLIA AND THE 3742 03:00:05,280 --> 03:00:08,040 PROPORTION IS INCREASING 3743 03:00:08,040 --> 03:00:09,520 DRAMATICALLY AS WELL AND NOW WE 3744 03:00:09,520 --> 03:00:11,360 HAVE A REPRESENTATIVE 3745 03:00:11,360 --> 03:00:14,760 DISTRIBUTION OF GLIA 3746 03:00:14,760 --> 03:00:16,800 RECONSTRUCTIONS FROM DOZENS OF 3747 03:00:16,800 --> 03:00:18,400 SPECIES. 3748 03:00:18,400 --> 03:00:20,320 RECONSTRUCTION SYSTEMS, CELL 3749 03:00:20,320 --> 03:00:23,160 TYPES AND SO FORTH. 3750 03:00:23,160 --> 03:00:25,440 SO PART OF THE EFFORT IN 3751 03:00:25,440 --> 03:00:27,040 SUPPORTING THIS INCREASE IN THE 3752 03:00:27,040 --> 03:00:29,840 DATA IS A PROGRESSIVE AUTOMATION 3753 03:00:29,840 --> 03:00:32,240 OF THE PROGRESS SO WE MOVE FROM 3754 03:00:32,240 --> 03:00:34,680 LARGELY MANUAL OPERATION TO A 3755 03:00:34,680 --> 03:00:37,800 SEMI MANUAL AND HOPEFULLY IN THE 3756 03:00:37,800 --> 03:00:40,320 FUTURE FULLY AUTOMATED OPERATION 3757 03:00:40,320 --> 03:00:45,400 AND THIS WAS HIGHLIGHTED AT THE 3758 03:00:45,400 --> 03:00:47,840 50th ANNIVERSARY WHICH WAS TWO 3759 03:00:47,840 --> 03:00:58,000 YEARS AGO. 3760 03:00:58,560 --> 03:01:00,600 AND SO PART OF THE PROCESS IS 3761 03:01:00,600 --> 03:01:04,800 GOING FROM A VERY MUCH HUMAN 3762 03:01:04,800 --> 03:01:06,840 CENTRIC PROCESSING AND USAGE OF 3763 03:01:06,840 --> 03:01:10,480 THE DATA TO MORE AND MORE 3764 03:01:10,480 --> 03:01:12,680 COMPUTERIZED PIPELINES AND 3765 03:01:12,680 --> 03:01:16,480 SERVICES IN AN INDEPENDENT WAY. 3766 03:01:16,480 --> 03:01:18,360 BOTH INCREASES THROUGH PUT OF 3767 03:01:18,360 --> 03:01:21,000 THE DATA BUT ALSO REDUCES THE 3768 03:01:21,000 --> 03:01:24,360 POSSIBILITY OF HUMAN INTRODUCED 3769 03:01:24,360 --> 03:01:27,760 MISTAKES IN THE DATA AND ONE 3770 03:01:27,760 --> 03:01:30,760 SERVICES WHAT WE CALL A 3771 03:01:30,760 --> 03:01:32,640 UNIVERSAL CONVERSION PROCESS 3772 03:01:32,640 --> 03:01:38,920 WHERE ALL OF THE SOURCES OF 3773 03:01:38,920 --> 03:01:41,880 RECONSTRUCTION CAN NOW BE 3774 03:01:41,880 --> 03:01:46,520 TRANSLATED INTO THE OPEN FORMAT. 3775 03:01:46,520 --> 03:01:48,960 AND WHEN WE LOOK AT THE USAGE OF 3776 03:01:48,960 --> 03:01:51,640 THE DATA WE TRACK BOTH DOWNLOADS 3777 03:01:51,640 --> 03:01:54,960 AND HITS AND WE TRACK 3778 03:01:54,960 --> 03:01:55,760 STATISTICS. 3779 03:01:55,760 --> 03:01:59,320 SO THAT NOT ONLY CONTRIBUTORS 3780 03:01:59,320 --> 03:02:02,200 CAN LOOK AT THE USAGE OF THEIR 3781 03:02:02,200 --> 03:02:04,160 DATA AND BE ACKNOWLEDGED. 3782 03:02:04,160 --> 03:02:07,880 BUT WE CAN TRACK TRENDS AND 3783 03:02:07,880 --> 03:02:11,080 EXPERIMENTAL CONDITIONS AND 3784 03:02:11,080 --> 03:02:15,880 AGAIN THIS IS CRITICAL FOR THAT 3785 03:02:15,880 --> 03:02:16,440 EFFORT. 3786 03:02:16,440 --> 03:02:18,440 WHEN WE LOOK AT WHERE THE DATA 3787 03:02:18,440 --> 03:02:19,840 ARE GOING. 3788 03:02:19,840 --> 03:02:22,920 NOT SURPRISINGLY THE MAJORITY OF 3789 03:02:22,920 --> 03:02:28,960 THE DATA GO TO THE SO-CALLED 3790 03:02:28,960 --> 03:02:31,600 WHAT USED TO BE CALLED FIRST 3791 03:02:31,600 --> 03:02:37,400 WORLD OR HIGH INCOME NATIONS. 3792 03:02:37,400 --> 03:02:43,640 THE EUROPEAN UNION AND AMERICA. 3793 03:02:43,640 --> 03:02:46,520 ABOUT A THIRD GOES TO THE 3794 03:02:46,520 --> 03:02:52,280 INTERNATIONAL MONETARY FUND AND 3795 03:02:52,280 --> 03:02:54,040 THEN TO THE LOWEST INCOME 3796 03:02:54,040 --> 03:02:54,800 COUNTRIES. 3797 03:02:54,800 --> 03:02:57,480 THIS DISTRIBUTION ACTUALLY 3798 03:02:57,480 --> 03:02:59,920 BECOMES MORE INTERESTING WHEN 3799 03:02:59,920 --> 03:03:01,920 YOU LOOK AT WHERE THE DATA ARE 3800 03:03:01,920 --> 03:03:02,680 COMING FROM. 3801 03:03:02,680 --> 03:03:04,720 SO THE UPLOADS INTO THE DATABASE 3802 03:03:04,720 --> 03:03:09,600 AND WE FIND THAT 80% OF THE 3803 03:03:09,600 --> 03:03:10,600 RECONSTRUCTIONS ARE NORTH 3804 03:03:10,600 --> 03:03:15,240 AMERICA AND THE EU AND NONE IN 3805 03:03:15,240 --> 03:03:18,000 AFRICA AND THE LOWER INCOME 3806 03:03:18,000 --> 03:03:18,560 COUNTRIES. 3807 03:03:18,560 --> 03:03:23,080 THE RESOURCE AND THE DATA 3808 03:03:23,080 --> 03:03:26,080 ON-LINE FOR FREE CREATES A FLOW 3809 03:03:26,080 --> 03:03:29,400 OF KNOWLEDGE ACCESS FROM THE 3810 03:03:29,400 --> 03:03:32,400 DATA PRODUCERS TO DATA USERS IN 3811 03:03:32,400 --> 03:03:36,200 A VERY GLOBAL WAY AND INCREASES 3812 03:03:36,200 --> 03:03:37,400 ACCESS INDEPENDENT OF NATIONAL 3813 03:03:37,400 --> 03:03:39,040 INCOME. 3814 03:03:39,040 --> 03:03:42,560 SO WHAT ARE THE DATA USED FOR. 3815 03:03:42,560 --> 03:03:43,880 WE TRACK THE LITERATURE. 3816 03:03:43,880 --> 03:03:46,760 SO WE HAVE A GOOD SENSE OF THAT. 3817 03:03:46,760 --> 03:03:50,520 IN ADDITION TO SCIENTIFIC 3818 03:03:50,520 --> 03:03:52,000 RESEARCH THERE HAVE BEEN 3819 03:03:52,000 --> 03:03:53,520 COMPETITIONS INCLUDING EARLY ON. 3820 03:03:53,520 --> 03:03:57,400 THE MAJOR SCIENCE OLYMPIA EVENT 3821 03:03:57,400 --> 03:04:02,680 IN CHINA IN 2011 AND NIH AND THE 3822 03:04:02,680 --> 03:04:06,200 HOWARD HUGHES SPONSORED 3823 03:04:06,200 --> 03:04:07,520 COMPETITION. 3824 03:04:07,520 --> 03:04:11,560 MANY ART EXHIBITs IN ALL SORTS 3825 03:04:11,560 --> 03:04:17,760 OF MEDIA AND INCREASING 3826 03:04:17,760 --> 03:04:19,400 EDUCATIONAL USE ABLE INCLUDING 3827 03:04:19,400 --> 03:04:22,640 BOOKS, MASSIVE ON-LINE COURSES 3828 03:04:22,640 --> 03:04:25,600 AS WELL AS ON-LINE EDUCATION AT 3829 03:04:25,600 --> 03:04:26,240 ALL LEVELS. 3830 03:04:26,240 --> 03:04:28,920 THAT REALLY EXPLODED DURING THE 3831 03:04:28,920 --> 03:04:31,040 COVID YEARS AND IS NOW 3832 03:04:31,040 --> 03:04:31,480 CONTINUING. 3833 03:04:31,480 --> 03:04:33,160 WE HAVE A LITTLE INFORMATION ON 3834 03:04:33,160 --> 03:04:34,840 NIH GRANTS THAT ARE BEING 3835 03:04:34,840 --> 03:04:37,560 SUBMITTED THAT PROPOSE TO USE 3836 03:04:37,560 --> 03:04:38,680 THE DATA. 3837 03:04:38,680 --> 03:04:40,360 HUNDREDS OF GRANTS FROM HUNDREDS 3838 03:04:40,360 --> 03:04:45,200 OF PPs AND INSTITUTIONS AND 3839 03:04:45,200 --> 03:04:48,840 GRAND TOTAL OF GOING TOWARDS 3840 03:04:48,840 --> 03:04:51,560 BILLION DOLLAR INVESTMENT AND 3841 03:04:51,560 --> 03:04:53,520 ABOUT 40% SUCCESS RATE WHICH IS 3842 03:04:53,520 --> 03:04:56,160 HIGHER THAN THE NIH AVERAGE. 3843 03:04:56,160 --> 03:04:58,480 AND THEN ALSO COMMERCIAL TECH 3844 03:04:58,480 --> 03:04:59,400 RESEARCH AND DEVELOPMENT 3845 03:04:59,400 --> 03:05:04,120 INCLUDING IMAGING SOFTWARE. 3846 03:05:04,120 --> 03:05:10,240 SO WITH RESPECT TO BIOMEDIC 3847 03:05:10,240 --> 03:05:14,040 RESEARCH MORPHOLOGY PROVIDES THE 3848 03:05:14,040 --> 03:05:16,240 FINGERPRINTING SIGNATURE. 3849 03:05:16,240 --> 03:05:18,480 MANY PEOPLE RECONSTRUCT THE 3850 03:05:18,480 --> 03:05:20,160 NEURON TO UNDERSTAND WHAT CELL 3851 03:05:20,160 --> 03:05:22,520 TYPES THEY ARE. 3852 03:05:22,520 --> 03:05:23,760 THAT THEY ARE LATCHING ON. 3853 03:05:23,760 --> 03:05:26,240 THERE IS A HUGE AMOUNT OF 3854 03:05:26,240 --> 03:05:28,680 COMPUTATIONAL MODELING. 3855 03:05:28,680 --> 03:05:32,560 TO UNDERSTAND THE BIOPHYSICS. 3856 03:05:32,560 --> 03:05:35,000 A LOT OF COMPARATIVE ANALYSIS ON 3857 03:05:35,000 --> 03:05:38,520 THE GEOMETRY TO COMPARE NOT ONLY 3858 03:05:38,520 --> 03:05:40,680 DISEASE CONDITIONS FROM 3859 03:05:40,680 --> 03:05:43,000 PHYSIOLOGICAL STATES BUT ALSO 3860 03:05:43,000 --> 03:05:45,680 DEVELOPMENTAL CHANGES AND CROSS 3861 03:05:45,680 --> 03:05:49,840 SPECIES COMPARISONS BETWEEN 3862 03:05:49,840 --> 03:05:52,280 ANATOMICAL REGIONS AND CELL 3863 03:05:52,280 --> 03:05:53,160 TYPES ETC. 3864 03:05:53,160 --> 03:05:55,920 MORE RECENTLY THE UNDERSTANDING 3865 03:05:55,920 --> 03:05:59,880 OF CIRCUITS THAT CAN BE 3866 03:05:59,880 --> 03:06:01,440 QUANTIFIED FOR THE POSSIBILITY 3867 03:06:01,440 --> 03:06:03,480 OF CELLS TO CONNECT TO EACH 3868 03:06:03,480 --> 03:06:05,040 OTHER. 3869 03:06:05,040 --> 03:06:07,680 AND THEN ALSO DATA MINING AT 3870 03:06:07,680 --> 03:06:09,120 LARGE AND EDUCATION AND 3871 03:06:09,120 --> 03:06:09,680 OUTREACH. 3872 03:06:09,680 --> 03:06:11,960 SO AS EXAMPLES THESE ARE SOME OF 3873 03:06:11,960 --> 03:06:17,840 THE EARLY STUDIES OF DISCOVERIES 3874 03:06:17,840 --> 03:06:21,160 BOTH IN RODENTS AND IN HUMANS A 3875 03:06:21,160 --> 03:06:23,960 AND RELATED COMPUTATIONS BASED 3876 03:06:23,960 --> 03:06:27,080 ON THE EXPERIMENTAL DATA. 3877 03:06:27,080 --> 03:06:29,000 MUCH MORE RECENT AND WE'RE 3878 03:06:29,000 --> 03:06:32,320 COMING IN THE RECENT YEARS OF 3879 03:06:32,320 --> 03:06:37,520 THE ADVENT OF HERO DENSITY NEURO 3880 03:06:37,520 --> 03:06:40,760 PIXEL PROBES THAT WERE TESTED IN 3881 03:06:40,760 --> 03:06:42,640 RODENT MODELS PEOPLE HAVE 3882 03:06:42,640 --> 03:06:46,640 STARTED IMPLANTING IN HUMANS. 3883 03:06:46,640 --> 03:06:49,160 THEY HAD TO DO EXTENSIVE 3884 03:06:49,160 --> 03:06:51,200 SIMULATIONS OF WHAT WAS THE 3885 03:06:51,200 --> 03:06:56,360 RIGHT ANGLE OF IMPLANT OF THOSE 3886 03:06:56,360 --> 03:06:59,520 PROBES BEFORE STARTING TO DRILL 3887 03:06:59,520 --> 03:07:03,320 IN THE SKULL AND LIVE PATIENTS. 3888 03:07:03,320 --> 03:07:07,240 THE COMPUTATION OF RADIATION 3889 03:07:07,240 --> 03:07:07,640 DAMAGE. 3890 03:07:07,640 --> 03:07:10,280 BOTH TO UNDERSTAND THE SIDE 3891 03:07:10,280 --> 03:07:13,880 EFFECTS OF RADIATION THERAPY AND 3892 03:07:13,880 --> 03:07:15,840 ALSO TO PREPARE FOR INTEREST 3893 03:07:15,840 --> 03:07:18,920 PLAN TORI TRAVEL SINCE NASA IS 3894 03:07:18,920 --> 03:07:22,600 NOW PLANNING ACTIVELY FOR HUMANS 3895 03:07:22,600 --> 03:07:24,920 ON MARCHES POTENTIALLY IN OUR 3896 03:07:24,920 --> 03:07:25,320 LIFETIME. 3897 03:07:25,320 --> 03:07:27,920 SO THE NUMBER OF PUBLICATIONS 3898 03:07:27,920 --> 03:07:32,160 WILL BE TOO HIGH FOR EVEN A LONG 3899 03:07:32,160 --> 03:07:35,320 DAY LET ALONE A FEW MINUTES BUT 3900 03:07:35,320 --> 03:07:37,600 WE'RE TALKING ABOUT THOUSANDS OF 3901 03:07:37,600 --> 03:07:39,720 PUBLICATIONS AND ALL MAJOR 3902 03:07:39,720 --> 03:07:41,120 JOURNALS. 3903 03:07:41,120 --> 03:07:44,440 IN 2022 WE HAD THE VERY NICE 3904 03:07:44,440 --> 03:07:46,320 MILESTONE OF THE NUMBER OF 3905 03:07:46,320 --> 03:07:50,200 SECONDARY PUBLICATIONS 3906 03:07:50,200 --> 03:07:54,640 SURPASSING THE NUMBER OF PRIMARY 3907 03:07:54,640 --> 03:07:56,800 PUBLICATIONS AND THE NUMBER OF 3908 03:07:56,800 --> 03:07:59,720 CITATIONS IS CREEPING UP TO NOW 3909 03:07:59,720 --> 03:08:03,040 50% OF THOSE OF THE PRIMARY 3910 03:08:03,040 --> 03:08:03,360 PUBLICATIONS. 3911 03:08:03,360 --> 03:08:06,440 THIS IS QUITE IMPRESSIVE. 3912 03:08:06,440 --> 03:08:10,200 THE SECONDARY PUBLICATIONS COME 3913 03:08:10,200 --> 03:08:12,800 AFTER THE PRIMARY PUBLICATIONS. 3914 03:08:12,800 --> 03:08:15,040 AT THE MINIMUM SHARING OF THE 3915 03:08:15,040 --> 03:08:19,320 DATA INCREASED THE IMPACT UP TO 3916 03:08:19,320 --> 03:08:21,880 150% OF THE ORIGINAL SOURCES AND 3917 03:08:21,880 --> 03:08:23,880 I FIND THAT VALUABLE AND 3918 03:08:23,880 --> 03:08:27,520 IMPRESSIVE. 3919 03:08:27,520 --> 03:08:28,920 WHAT IS THE ADVANTAGE FOR THE 3920 03:08:28,920 --> 03:08:32,320 DATA PROVIDERS. 3921 03:08:32,320 --> 03:08:35,520 IT TURNS OUT THAT SHARING DATA 3922 03:08:35,520 --> 03:08:38,360 PROVIDES AN AVERAGE 13% INCREASE 3923 03:08:38,360 --> 03:08:42,640 IN CITATIONS AND THIS TRANSLATES 3924 03:08:42,640 --> 03:08:45,000 INTO THE NICE THINGS THAT 3925 03:08:45,000 --> 03:08:47,480 ACCOUNT FOR PROMOTION, TENURE, 3926 03:08:47,480 --> 03:08:48,520 AWARDS ETC. 3927 03:08:48,520 --> 03:08:52,720 AND WE'RE GOING TO RELEASE THE 3928 03:08:52,720 --> 03:08:54,720 ANALYSIS BUT ALSO AN AUTHOR 3929 03:08:54,720 --> 03:08:57,920 REPORTING SERVICE SO THAT 3930 03:08:57,920 --> 03:09:04,280 AUTHORS WILL BE NOTIFIED WHICH 3931 03:09:04,280 --> 03:09:07,560 WILL PROVIDE FURTHER INCENTIVE. 3932 03:09:07,560 --> 03:09:10,240 THEIR DATA IS NOT ONLY PUBLISHED 3933 03:09:10,240 --> 03:09:12,760 BUT REUSED IN THE COMMUNITY. 3934 03:09:12,760 --> 03:09:16,080 I'LL STOP HERE BUT NOT BEFORE 3935 03:09:16,080 --> 03:09:18,640 THANKING THE REALLY INSTITUTIONS 3936 03:09:18,640 --> 03:09:20,840 AND PEOPLE WHO ENABLED THIS WORK 3937 03:09:20,840 --> 03:09:22,160 OVER THE YEARS. 3938 03:09:22,160 --> 03:09:24,400 MOST AND FOREMOST NIH THAT 3939 03:09:24,400 --> 03:09:27,480 FUNDED THIS WORK FROM THE VERY 3940 03:09:27,480 --> 03:09:33,760 GET-GO. 3941 03:09:33,760 --> 03:09:35,080 THE DEPARTMENT OF ENERGY. 3942 03:09:35,080 --> 03:09:40,120 IN GREEN ARE THE ACTIVE GRANTS. 3943 03:09:40,120 --> 03:09:50,680 A VALIANT GROUP OF TRAINEES AND 3944 03:09:57,520 --> 03:10:04,680 THE GROWTH HAS BEEN THRUSTED. 3945 03:10:04,680 --> 03:10:06,760 >>THANK YOU VERY MUCH. 3946 03:10:06,760 --> 03:10:08,720 CLEARLY A REMARKABLE PLATFORM 3947 03:10:08,720 --> 03:10:11,800 AND EXAMPLE OF THE POWER OF DATA 3948 03:10:11,800 --> 03:10:12,400 SHARING. 3949 03:10:12,400 --> 03:10:14,560 BEFORE WE GET TO THE QUESTIONS 3950 03:10:14,560 --> 03:10:18,080 FIRST WE'LL MOVE ON TO OUR NEXT 3951 03:10:18,080 --> 03:10:19,760 SPEAKER. 3952 03:10:19,760 --> 03:10:21,720 EUN-YOUNG MUN. 3953 03:10:21,720 --> 03:10:24,400 WHO IS A PROFESSOR AT NORTH 3954 03:10:24,400 --> 03:10:32,560 TEXAS UNIVERSITY. 3955 03:10:32,560 --> 03:10:35,320 >>HELLO. 3956 03:10:35,320 --> 03:10:39,280 MY VIDEO IS STOPPED BY THE 3957 03:10:39,280 --> 03:10:40,960 ORGANIZER. 3958 03:10:40,960 --> 03:10:49,320 >>LET'S SEE. 3959 03:10:49,320 --> 03:10:55,080 I'LL SHARE THE SCREEN. 3960 03:10:55,080 --> 03:10:58,520 CAN YOU SEE MY SCREEN? 3961 03:10:58,520 --> 03:10:59,920 >>YES, WE CAN. 3962 03:10:59,920 --> 03:11:00,200 >>OKAY. 3963 03:11:00,200 --> 03:11:02,520 THANK YOU FOR THE OPPORTUNITY TO 3964 03:11:02,520 --> 03:11:05,440 PRESENT OUR WORK. 3965 03:11:05,440 --> 03:11:09,800 I'M EUN-YOUNG MUN. 3966 03:11:09,800 --> 03:11:17,840 I WANT TO THANK NATIONAL 3967 03:11:17,840 --> 03:11:19,840 INSTITUTE OF ALCOHOL ABUSE AND 3968 03:11:19,840 --> 03:11:23,760 ALCOHOLISM. 3969 03:11:23,760 --> 03:11:25,960 VERY HAPPY TO SHARE OUR 3970 03:11:25,960 --> 03:11:30,600 EXPERIENCE IN THIS SYMPOSIUM. 3971 03:11:30,600 --> 03:11:31,880 THE NEXT SLIDE PROVIDES AN 3972 03:11:31,880 --> 03:11:35,000 OUTLINE FOR THE TALK. 3973 03:11:35,000 --> 03:11:38,960 THE PROJECT BACKGROUND AND 3974 03:11:38,960 --> 03:11:39,400 OUTCOMES. 3975 03:11:39,400 --> 03:11:42,440 PROJECT INTEGRATE WAS LAUNCHED 3976 03:11:42,440 --> 03:11:44,440 IN 2010 AND WE OBTAINED 3977 03:11:44,440 --> 03:11:48,120 INDIVIDUAL PARTICIPANT DATA FROM 3978 03:11:48,120 --> 03:11:51,320 24 TRIALS. 3979 03:11:51,320 --> 03:12:01,800 12,000 CASES AT BASELINE. 3980 03:12:03,440 --> 03:12:08,200 WE ARE ONE OF THE FIRST 3981 03:12:08,200 --> 03:12:10,480 PROJECTS THAT EMBRACE DATA 3982 03:12:10,480 --> 03:12:15,280 INTEGRATION CHALLENGES. 3983 03:12:15,280 --> 03:12:17,880 IN ADDITION WE COMMUNICATED WITH 3984 03:12:17,880 --> 03:12:19,000 THE ORIGINAL INVESTIGATORS WHEN 3985 03:12:19,000 --> 03:12:22,000 WE HAD A QUESTION AND THEY WERE 3986 03:12:22,000 --> 03:12:24,080 VERY GENEROUS WITH THEIR TIME. 3987 03:12:24,080 --> 03:12:29,960 7 WE THEN ANALYZED DATA. 3988 03:12:29,960 --> 03:12:37,440 OUR GOALS WERE TO PROVIDE LARGE 3989 03:12:37,440 --> 03:12:38,800 SCALE EVIDENCE. 3990 03:12:38,800 --> 03:12:42,000 THUS FAR WE HAVE CONTRIBUTED 3991 03:12:42,000 --> 03:12:46,960 OVER 65 ARTICLES. 3992 03:12:46,960 --> 03:12:56,320 WE SUPPORTED 7 POSTDOCS. 3993 03:12:56,320 --> 03:12:59,280 WE DEVELOP YouTube CONTENT. 3994 03:12:59,280 --> 03:13:02,200 WE HAD FUN MAKING IT AND I GUESS 3995 03:13:02,200 --> 03:13:07,120 WHAT IS IMPORTANT HERE IS SINCE 3996 03:13:07,120 --> 03:13:12,720 2019 WE STUDIED ALSO SHARED AND 3997 03:13:12,720 --> 03:13:20,000 IDENTIFIED DATA. 3998 03:13:20,000 --> 03:13:25,040 OUR FIRST DATA THAT WE SHARED IN 3999 03:13:25,040 --> 03:13:27,400 2019 HAS HAD HAD ALMOST 900 4000 03:13:27,400 --> 03:13:31,600 VIEWERS. 4001 03:13:31,600 --> 03:13:41,880 WE HAVE USED DATA IN THE SPACE. 4002 03:13:41,880 --> 03:13:46,720 IT HAS BEEN USED AS A TRAINING 4003 03:13:46,720 --> 03:13:47,280 DATASET. 4004 03:13:47,280 --> 03:13:50,840 OR AS A REAL DATASET TO PASS NEW 4005 03:13:50,840 --> 03:13:52,760 STATISTICAL MODELS. 4006 03:13:52,760 --> 03:14:03,240 OTHERS HAVE DOWNLOADED DATA. 4007 03:14:03,800 --> 03:14:06,880 ULTIMATE LEADS WE CAN SPEED UP 4008 03:14:06,880 --> 03:14:10,160 SCIENTIFIC DISCOVERIES. 4009 03:14:10,160 --> 03:14:15,200 SO THE TEAMS THUS FAR 124 UNIQUE 4010 03:14:15,200 --> 03:14:17,680 INDIVIDUALS HAVE CONTRIBUTED TO 4011 03:14:17,680 --> 03:14:20,240 THE PROJECT WITH 10 INDIVIDUALS 4012 03:14:20,240 --> 03:14:21,840 BEING MOST ACTIVE AND CURRENTLY 4013 03:14:21,840 --> 03:14:29,000 ON THE PROJECT AND -- UNIVERSITY 4014 03:14:29,000 --> 03:14:31,760 OF OREGON, UNIVERSITY OF HONG 4015 03:14:31,760 --> 03:14:32,760 KONG. 4016 03:14:32,760 --> 03:14:43,200 UNIVERSITY OF WASHINGTON. 4017 03:14:47,480 --> 03:14:51,440 WE ALSO WANT TO SHOW THE LIST OF 4018 03:14:51,440 --> 03:14:51,880 INVESTIGATORS. 4019 03:14:51,880 --> 03:14:53,800 MOST OF THEM ARE ACTIVE IN THE 4020 03:14:53,800 --> 03:14:57,040 FIELD AND HAVE SUPPORTED THE 4021 03:14:57,040 --> 03:14:57,720 PROJECT. 4022 03:14:57,720 --> 03:15:00,240 I EXPRESS MY APPRECIATION FOR 4023 03:15:00,240 --> 03:15:01,680 THEIR CONTRIBUTION. 4024 03:15:01,680 --> 03:15:05,040 SINCE THIS IS A CELEBRATORY 4025 03:15:05,040 --> 03:15:06,600 SYMPOSIUM TO SHOWCASE THE 4026 03:15:06,600 --> 03:15:08,680 SUCCESS OF DATA REUSE AND 4027 03:15:08,680 --> 03:15:10,720 SHARING I WILL SHOW YOU SOME 4028 03:15:10,720 --> 03:15:11,520 GRAPH HERE. 4029 03:15:11,520 --> 03:15:14,960 THIS SLIDE SHOWS A NETWORK OVER 4030 03:15:14,960 --> 03:15:15,440 TIME. 4031 03:15:15,440 --> 03:15:21,680 THE FIRST TWO YEARS EACH -- IT 4032 03:15:21,680 --> 03:15:23,560 WAS SPARSE AND LIMITED. 4033 03:15:23,560 --> 03:15:26,760 EACH IS SHOWN AS A RED NODE AND 4034 03:15:26,760 --> 03:15:31,240 THE COLLABORATION AMONG AUTHORS 4035 03:15:31,240 --> 03:15:35,520 ARE THE BLUE EDGES. 4036 03:15:35,520 --> 03:15:39,200 OVER THE YEARS IT HAS BECOME 4037 03:15:39,200 --> 03:15:48,840 QUITE ENLARGED AND WI -- 4038 03:15:48,840 --> 03:15:50,760 STRENGTHENED CONNECTIONS OVER 4039 03:15:50,760 --> 03:15:52,160 TIME. 4040 03:15:52,160 --> 03:15:59,960 THE GREEN NODES PUNILY 4041 03:15:59,960 --> 03:16:01,720 INDICATION FROM A SUPPORTED 4042 03:16:01,720 --> 03:16:11,960 PROJECT AND THE RED CITATIONS. 4043 03:16:11,960 --> 03:16:14,840 THE CONNECTIONS HAVE BEEN PRETTY 4044 03:16:14,840 --> 03:16:17,080 WEAK BUT NOW AT THE END' LAST 4045 03:16:17,080 --> 03:16:20,280 YEAR THE CONNECTIONS HAVE GOTTEN 4046 03:16:20,280 --> 03:16:22,920 STRONGER AND IT HAS GOTTEN QUITE 4047 03:16:22,920 --> 03:16:25,880 LARGE. 4048 03:16:25,880 --> 03:16:27,800 OVER-ALL THESE TWO SLIDES 4049 03:16:27,800 --> 03:16:28,880 SUGGEST THE PROJECT AND IMPACT 4050 03:16:28,880 --> 03:16:31,800 ON THE FIELD HAVE GROWN. 4051 03:16:31,800 --> 03:16:34,360 THE SUCCESS OF THE PROJECT 4052 03:16:34,360 --> 03:16:36,600 INTEGRATE MAY BE DUE TO OUR TEAM 4053 03:16:36,600 --> 03:16:38,320 SCIENCE APPROACH. 4054 03:16:38,320 --> 03:16:42,960 THE MEMBERS BRING A WIDE RANGE 4055 03:16:42,960 --> 03:16:53,360 OF DOMAIN OF EXPERTISE. 4056 03:16:56,280 --> 03:16:58,240 NEXT I WANT TO SHOW YOU SOME 4057 03:16:58,240 --> 03:17:00,240 SELECT OUTCOMES THAT WE'VE 4058 03:17:00,240 --> 03:17:02,200 PRODUCED. 4059 03:17:02,200 --> 03:17:04,760 IN TYPICAL META-ANALYSIS IT'S 4060 03:17:04,760 --> 03:17:12,560 IMPORTANT TO HAVE THE SAME -- OR 4061 03:17:12,560 --> 03:17:15,480 EQUIVALENT MEASURES OF STUDIES. 4062 03:17:15,480 --> 03:17:24,080 IN THE CASE OF BRIEF ALCOHOL 4063 03:17:24,080 --> 03:17:25,600 INTERVENTIONS -- HOW MANY 4064 03:17:25,600 --> 03:17:29,800 STANDARD DRINKS ONE HAD IN A 4065 03:17:29,800 --> 03:17:32,400 TYPICAL WEEK. 4066 03:17:32,400 --> 03:17:35,280 0 MEANS NO DRINK. 4067 03:17:35,280 --> 03:17:38,680 AND IT'S A NICE MEASURE WHERE 4068 03:17:38,680 --> 03:17:40,320 EVERYBODY USES AND IT'S THE SAME 4069 03:17:40,320 --> 03:17:44,040 MEASURE ACROSS OUR STUDIES 4070 03:17:44,040 --> 03:17:48,040 HOWEVER THE HISTORIC GRAM OF THE 4071 03:17:48,040 --> 03:17:53,200 NUMBER OF DRINKS, OUTCOME 4072 03:17:53,200 --> 03:17:56,120 DISTRIBUTIONS SIGNIFICANTLY 4073 03:17:56,120 --> 03:17:59,480 DIFFER BY STUDIES. 4074 03:17:59,480 --> 03:18:04,240 RESULTING IN A NEED TO ANALYZE 4075 03:18:04,240 --> 03:18:04,880 DATA. 4076 03:18:04,880 --> 03:18:07,440 SO MOST STUDIES OF A ZERO 4077 03:18:07,440 --> 03:18:12,200 INFLATION AND MANY HAVE THIS 4078 03:18:12,200 --> 03:18:12,400 VERSION. 4079 03:18:12,400 --> 03:18:15,400 IF YOU LOOK AT THE STUDY SIDE BY 4080 03:18:15,400 --> 03:18:21,080 SIDE STUDY ONE HAD EXCESSIVE 0 4081 03:18:21,080 --> 03:18:24,520 HERE AND STUDY 12 TARGETED HEAVY 4082 03:18:24,520 --> 03:18:25,200 DRINKING INDIVIDUALS. 4083 03:18:25,200 --> 03:18:35,640 IT ACQUIRES DIFFERENT 4084 03:18:39,080 --> 03:18:41,880 STATISTICAL MODELS TO BE USED TO 4085 03:18:41,880 --> 03:18:45,320 ANALYZE AN AVERAGE OVER-ALL 4086 03:18:45,320 --> 03:18:48,520 EFFECT SIZE OF -- OUTPUT 4087 03:18:48,520 --> 03:18:50,440 INNOVATIONS. 4088 03:18:50,440 --> 03:18:55,960 WHEN WE USED MARGINALIZE ENDS 4089 03:18:55,960 --> 03:19:00,160 AND INFLATED MODELS WE CAN 4090 03:19:00,160 --> 03:19:05,120 INTERPRET INTERVENTION EFFECT 4091 03:19:05,120 --> 03:19:08,680 DESPITE INFLATION AND WITH THIS 4092 03:19:08,680 --> 03:19:10,560 INNOVATION WE CONCLUDED THE 4093 03:19:10,560 --> 03:19:14,200 BRIEF INNOVATION HAD 8% OF THE 4094 03:19:14,200 --> 03:19:15,760 ADVANTAGE RIGHT HERE. 4095 03:19:15,760 --> 03:19:17,760 THROUGH SIX MONTHS POST 4096 03:19:17,760 --> 03:19:19,200 INNOVATION. 4097 03:19:19,200 --> 03:19:21,240 COMPARED TO CONTROLS. 4098 03:19:21,240 --> 03:19:23,680 SO THIS WAS AN EXAMPLE THAT 4099 03:19:23,680 --> 03:19:25,920 THROUGH DATA REUSE WE DREW A 4100 03:19:25,920 --> 03:19:30,120 MORE DETAILED CLINICAL 4101 03:19:30,120 --> 03:19:36,560 MEANINGFUL INTERPRETATION. 4102 03:19:36,560 --> 03:19:41,960 WE PRODUCE A LONG LASTING 4103 03:19:41,960 --> 03:19:45,240 BENEFIT OF FACTS. 4104 03:19:45,240 --> 03:19:51,840 THIS SLIDE SHOWS SOME STUDIES 4105 03:19:51,840 --> 03:19:59,000 TARGETED RELATIVELY LOW. 4106 03:19:59,000 --> 03:20:02,320 THE OVER-ALL -- MEAN NUMBER OF 4107 03:20:02,320 --> 03:20:04,720 DRINK REQUESTS IS WHATS ABOUT 9 4108 03:20:04,720 --> 03:20:09,240 PER WEEK. 4109 03:20:09,240 --> 03:20:19,760 HOWEVER ON AVERAGE THOSE -- IT 4110 03:20:20,720 --> 03:20:25,720 CAN BE CHALLENGING ESPECIALLY IF 4111 03:20:25,720 --> 03:20:28,640 IT'S A FACT -- LIMITED. 4112 03:20:28,640 --> 03:20:32,040 HEAVIER DRINKING INDIVIDUALS IN 4113 03:20:32,040 --> 03:20:37,200 STUDIES IN 11 AND 15 MAY NOT 4114 03:20:37,200 --> 03:20:40,160 MEET THE STUDY INCLUSION. 4115 03:20:40,160 --> 03:20:44,320 SO IF THE TRIAL STATES THAT 4116 03:20:44,320 --> 03:20:50,160 PREINNOVATION -- THIS SHOULD BE 4117 03:20:50,160 --> 03:20:53,360 INTERPRETED WITH A CAVEATS. 4118 03:20:53,360 --> 03:20:55,800 MEAN NUMBER OF DRINKS THAT ARE 4119 03:20:55,800 --> 03:20:59,960 DIFFERENT FOR MEN AND WOMEN. 4120 03:20:59,960 --> 03:21:05,200 BECAUSE MEN DRINK MORE THAN 4121 03:21:05,200 --> 03:21:09,480 WOMAN. 4122 03:21:09,480 --> 03:21:15,960 SO BY KEEPING THESE ELEMENTS 4123 03:21:15,960 --> 03:21:23,360 APART -- WE ARE CURRENTLY 4124 03:21:23,360 --> 03:21:30,360 EXAMINING A BASELINE USING 4125 03:21:30,360 --> 03:21:30,680 META-ANALYSIS. 4126 03:21:30,680 --> 03:21:38,240 THIS IS -- FOR FEMALE CAN GO 4127 03:21:38,240 --> 03:21:41,080 STUDENTS -- EFFECTIVE AROUND SIX 4128 03:21:41,080 --> 03:21:44,280 DRINKS PER WEEK AND 18 DRINKS A 4129 03:21:44,280 --> 03:21:44,880 WEEK. 4130 03:21:44,880 --> 03:21:49,520 SO BASED ON THIS FINDING BRIEF 4131 03:21:49,520 --> 03:21:51,560 ACCURATE INNOVATIONS WOULD BE 4132 03:21:51,560 --> 03:21:54,560 SUITABLE FOR ANYONE WHO DRINKS 4133 03:21:54,560 --> 03:21:55,040 SOCIALLY. 4134 03:21:55,040 --> 03:21:59,760 HOWEVER GIVEN THE WIDE RANGE OF 4135 03:21:59,760 --> 03:22:01,800 CONFIDENCE INTERVALS A BETTER 4136 03:22:01,800 --> 03:22:04,360 DESIGN STUDY MAY BE NEEDED FOR 4137 03:22:04,360 --> 03:22:14,720 OTHERS WHO DRINK MORE. 4138 03:22:19,080 --> 03:22:24,040 I HAD REGULAR TALK WITH A 4139 03:22:24,040 --> 03:22:25,040 PROJECT INTEGRATING TEAM. 4140 03:22:25,040 --> 03:22:31,760 THOSE WHO SHARE DATA KNOW THEIR 4141 03:22:31,760 --> 03:22:40,520 VALUABLE DATA GET EXTENDED. 4142 03:22:40,520 --> 03:22:42,520 AND IT HAS HELPED THEM TO 4143 03:22:42,520 --> 03:22:51,680 UNDERSTAND THEIR DATA. 4144 03:22:51,680 --> 03:22:56,120 FROM OUR END WE HAVE DEVELOPED 4145 03:22:56,120 --> 03:23:00,520 NEW RESEARCH QUESTIONS PROVIDED 4146 03:23:00,520 --> 03:23:02,720 LARGE SCALE EVIDENCE AND 4147 03:23:02,720 --> 03:23:06,160 DEVELOPED NEW METHODS AND IDEAS. 4148 03:23:06,160 --> 03:23:09,920 THIS IS ALL IN COLLABORATIVE 4149 03:23:09,920 --> 03:23:13,640 SITUATIONS. 4150 03:23:13,640 --> 03:23:15,960 IT IS NECESSARY TO PROVIDE MORE 4151 03:23:15,960 --> 03:23:19,680 EDUCATION AND MORE HELPFUL 4152 03:23:19,680 --> 03:23:25,440 TOOLS. 4153 03:23:25,440 --> 03:23:27,400 INCENTIVES TO TRACKING 4154 03:23:27,400 --> 03:23:31,880 CONTRIBUTIONS TO SCIENCE. 4155 03:23:31,880 --> 03:23:33,880 THANK YOU FOR LISTENING TO THIS 4156 03:23:33,880 --> 03:23:35,160 TALK. 4157 03:23:35,160 --> 03:23:39,480 IF YOU HAVE ANY QUESTIONS YOU 4158 03:23:39,480 --> 03:23:47,000 CAN I -- 4159 03:23:47,000 --> 03:23:48,840 >>YES. 4160 03:23:48,840 --> 03:23:50,800 WE CAN MOVE FORWARD WITH A FEW 4161 03:23:50,800 --> 03:23:51,040 QUESTIONS. 4162 03:23:51,040 --> 03:23:52,600 THERE ARE A FEW QUESTIONS IN THE 4163 03:23:52,600 --> 03:23:53,120 CHAT. 4164 03:23:53,120 --> 03:23:55,960 THANK YOU VERY MUCH FOR THOSE. 4165 03:23:55,960 --> 03:23:58,920 FIRST ONE TO GEORGIO. 4166 03:23:58,920 --> 03:24:02,480 I THINK THEY ARE QUITE 4167 03:24:02,480 --> 03:24:04,000 INTERESTED -- SORRY. 4168 03:24:04,000 --> 03:24:05,920 I'M JUST MOVING THROUGH THESE 4169 03:24:05,920 --> 03:24:07,760 NOW. 4170 03:24:07,760 --> 03:24:09,560 TELL US MORE ABOUT THE ATTITUDES 4171 03:24:09,560 --> 03:24:12,000 HOW THE ATTITUDES YOU THINK 4172 03:24:12,000 --> 03:24:13,760 SHIFTED IN DATA SHARING AND 4173 03:24:13,760 --> 03:24:15,360 WHERE YOU SEE THAT MOVING 4174 03:24:15,360 --> 03:24:16,000 FORWARD. 4175 03:24:16,000 --> 03:24:19,080 THE GRAPH YOU SHOWED GEORGIO IS 4176 03:24:19,080 --> 03:24:20,360 QUITE REMARKABLE IN THE UP TAKE 4177 03:24:20,360 --> 03:24:23,200 AND THE TIME THAT IT STARTED. 4178 03:24:23,200 --> 03:24:27,160 YOU MENTIONED SOME OF THE 4179 03:24:27,160 --> 03:24:28,880 CRITERIA AT REASONS FOR THAT. 4180 03:24:28,880 --> 03:24:31,960 MAYBE YOU CAN EXPOUND ON THAT 4181 03:24:31,960 --> 03:24:35,840 AND ANY INSIGHTS YOU MIGHT HAVE 4182 03:24:35,840 --> 03:24:37,520 ABOUT SEEING THAT MORE BROADLY 4183 03:24:37,520 --> 03:24:39,640 ACROSS DATA SHARING 4184 03:24:39,640 --> 03:24:40,240 >>YES. 4185 03:24:40,240 --> 03:24:43,560 I HAVE SOME EVIDENCE BASED 4186 03:24:43,560 --> 03:24:44,960 INFORMATION ON THIS. 4187 03:24:44,960 --> 03:24:46,760 THE FIRST THING TO NOTICE IS 4188 03:24:46,760 --> 03:24:48,760 THAT UNLIKE SOME OF THE VERY 4189 03:24:48,760 --> 03:24:50,200 IMPORTANT CONSIDERATIONS THAT 4190 03:24:50,200 --> 03:24:52,920 WERE DISCUSSED EARLIER TODAY 4191 03:24:52,920 --> 03:24:55,560 THERE IS NO ISSUE OF PRIVACY. 4192 03:24:55,560 --> 03:24:57,640 THESE ARE NEURONS THAT ARE 4193 03:24:57,640 --> 03:24:59,600 RECONSTRUCTED LARGELY FROM 4194 03:24:59,600 --> 03:25:01,680 ANIMALS AND NEURONS 4195 03:25:01,680 --> 03:25:03,600 RECONSTRUCTED FROM HUMAN 4196 03:25:03,600 --> 03:25:05,040 PATIENTS AND HUMAN TISSUE. 4197 03:25:05,040 --> 03:25:07,120 THERE IS NO WAY TO IDENTIFY 4198 03:25:07,120 --> 03:25:09,040 INDIVIDUALS BASED ON THE SHAPE 4199 03:25:09,040 --> 03:25:10,560 OF INDIVIDUAL NEURONS IN ANY 4200 03:25:10,560 --> 03:25:11,120 WAY. 4201 03:25:11,120 --> 03:25:13,440 SO THERE IS NO ISSUE OF PRIVACY. 4202 03:25:13,440 --> 03:25:16,400 THERE IS NO ISSUE OF IP IF THE 4203 03:25:16,400 --> 03:25:20,800 DATA ARE PUBLISHED IN BIOMEDICAL 4204 03:25:20,800 --> 03:25:21,640 JOURNALS. 4205 03:25:21,640 --> 03:25:23,240 HOWEVER THERE IS AN ISSUE OF 4206 03:25:23,240 --> 03:25:24,000 OWNERSHIP. 4207 03:25:24,000 --> 03:25:26,080 THE ISSUE CAME UP MANY TIMES. 4208 03:25:26,080 --> 03:25:27,640 WHO'S OWNING THE DATA? 4209 03:25:27,640 --> 03:25:30,160 DOES THE DATA BELONG TO THE 4210 03:25:30,160 --> 03:25:30,680 RESEARCHERS. 4211 03:25:30,680 --> 03:25:34,680 TO THE INSTITUTIONS THAT THE 4212 03:25:34,680 --> 03:25:36,800 RESEARCHER WORKS FOR OR TO THE 4213 03:25:36,800 --> 03:25:38,680 PUBLIC TO THE TAXPAYERS TO THE 4214 03:25:38,680 --> 03:25:39,120 FUNDERS. 4215 03:25:39,120 --> 03:25:43,400 7 ULTIMATELY THERE IS A MATTER 4216 03:25:43,400 --> 03:25:45,120 OF PERSONAL INTEREST BECAUSE 4217 03:25:45,120 --> 03:25:46,560 REASONS THAT RESEARCHERS DO NOT 4218 03:25:46,560 --> 03:25:49,200 WANT TO SHARE THEIR DATA IT 4219 03:25:49,200 --> 03:25:51,560 TAKES TIME TO SHARE DATA. 4220 03:25:51,560 --> 03:25:52,880 SOMETIMES THE PAPERS ARE 4221 03:25:52,880 --> 03:25:54,640 PUBLISHED YEARS AFTER THE DATA 4222 03:25:54,640 --> 03:25:55,800 ARE COLLECTED. 4223 03:25:55,800 --> 03:25:59,080 THOSE DATA MAY NOW BE IN BACK 4224 03:25:59,080 --> 03:26:01,040 UPS AND IT MAY TAKE TIME TO 4225 03:26:01,040 --> 03:26:02,160 RETRIEVE THEM. 4226 03:26:02,160 --> 03:26:04,280 THE POSTDOCS AND GRAD STUDENTS 4227 03:26:04,280 --> 03:26:05,960 WHO COLLECTED THOSE DATA MIGHT 4228 03:26:05,960 --> 03:26:08,080 HAVE LEFT FOR THEIR NEXT JOB AND 4229 03:26:08,080 --> 03:26:10,640 THE PI MAY NOT HAVE BEEN IN 4230 03:26:10,640 --> 03:26:14,720 TOUCH WITH THE DATA. THERE IS 4231 03:26:14,720 --> 03:26:17,880 ALSO AN ISSUE OF SOME FEAR. 4232 03:26:17,880 --> 03:26:20,400 FEAR OF BEING SCOOPED WITH THEIR 4233 03:26:20,400 --> 03:26:22,160 OWN DATA. 4234 03:26:22,160 --> 03:26:24,920 FEAR OF BEING PROVEN WRONG. 4235 03:26:24,920 --> 03:26:27,000 OF SIMPLY INCREASING THE 4236 03:26:27,000 --> 03:26:27,720 COMPETITION. 4237 03:26:27,720 --> 03:26:29,920 IT TOOK MANY YEARS TO COLLECT 4238 03:26:29,920 --> 03:26:33,760 THIS DATA AND SOMEONE IS GOING 4239 03:26:33,760 --> 03:26:40,040 TO REUSE MY DATA IN A PAY OFF 4240 03:26:40,040 --> 03:26:42,240 WAY. 4241 03:26:42,240 --> 03:26:44,040 SO WHY SHOULD I GIVE SOMEBODY 4242 03:26:44,040 --> 03:26:45,000 ELSE AN ADVANTAGE. 4243 03:26:45,000 --> 03:26:46,760 THEY SHOULD GO AND COLLECT THEIR 4244 03:26:46,760 --> 03:26:48,080 OWN DATA. 4245 03:26:48,080 --> 03:26:49,960 SO THERE ARE REASONS THAT ARE 4246 03:26:49,960 --> 03:26:51,400 VERY UNDERSTANDABLE FROM THE 4247 03:26:51,400 --> 03:26:53,880 POINT OF VIEW OF HUMAN 4248 03:26:53,880 --> 03:26:54,280 PSYCHOLOGY. 4249 03:26:54,280 --> 03:26:55,840 WE HAVE TO LOOK AT OUR HEARTS 4250 03:26:55,840 --> 03:26:57,520 AND THINK OF WHAT WE COLLECT 4251 03:26:57,520 --> 03:26:58,240 DATA FOR. 4252 03:26:58,240 --> 03:27:00,880 IT'S NOT THAT WE DO THAT JUST 4253 03:27:00,880 --> 03:27:03,720 FERRYING OH AND JUST FOR GLORY. 4254 03:27:03,720 --> 03:27:05,640 WE BELIEVE IN RESEARCH AND 4255 03:27:05,640 --> 03:27:08,080 PUSHING THE PROGRESS THE 4256 03:27:08,080 --> 03:27:10,320 ENVELOPE OF SCIENCE AND THE 4257 03:27:10,320 --> 03:27:11,120 STATE-OF-THE-ART OF KNOWLEDGE 4258 03:27:11,120 --> 03:27:13,120 AND THERE IS NO DOUBT IN 4259 03:27:13,120 --> 03:27:14,680 ANYONE'S MIND THAT SHARING THE 4260 03:27:14,680 --> 03:27:17,880 DATA ACTUALLY IMPROVES THAT AT A 4261 03:27:17,880 --> 03:27:20,040 SOCIETAL LEVEL AT LEAST AT AN 4262 03:27:20,040 --> 03:27:20,760 INDIVIDUAL LEVEL. 4263 03:27:20,760 --> 03:27:22,040 SO WHAT CHANGED? 4264 03:27:22,040 --> 03:27:24,000 I THINK MANUFACTURERS. 4265 03:27:24,000 --> 03:27:27,120 ONE IS A GENERATIONAL SHIFT. 4266 03:27:27,120 --> 03:27:30,640 SOME FAMOUS SCIENTISTS SAID A 4267 03:27:30,640 --> 03:27:36,600 TRULY REVOLUTIONARY SCIENTIFIC 4268 03:27:36,600 --> 03:27:38,360 THEORIES, THE OLD PEOPLE DIE AND 4269 03:27:38,360 --> 03:27:41,000 THE YOUNG PEOPLE STUDY THEM IN 4270 03:27:41,000 --> 03:27:41,440 TEXTBOOKS. 4271 03:27:41,440 --> 03:27:45,440 THERE IS NO DOUBT THAT OLDER 4272 03:27:45,440 --> 03:27:48,760 PIs ARE MORE HESITANT TO SHARE 4273 03:27:48,760 --> 03:27:51,240 DATA. YOUNGER PEOPLE, THEY 4274 03:27:51,240 --> 03:27:53,200 LIVED IN THE WORLD OF OPENNESS 4275 03:27:53,200 --> 03:27:55,120 INTERNET FROM THE GET-GO FROM 4276 03:27:55,120 --> 03:27:57,120 WHEN THEY WERE BORN AND THERE IS 4277 03:27:57,120 --> 03:27:58,080 NOT EVEN A QUESTION. 4278 03:27:58,080 --> 03:27:59,720 OF COURSE THE DATA ARE GOING TO 4279 03:27:59,720 --> 03:28:00,720 BE PUBLIC. 4280 03:28:00,720 --> 03:28:02,960 THE SECOND ISSUE HAS TO DO WITH 4281 03:28:02,960 --> 03:28:03,960 EVIDENCE OF THE SUPPORT. 4282 03:28:03,960 --> 03:28:06,280 PEOPLE ARE NOW LOOKING MORE AND 4283 03:28:06,280 --> 03:28:09,720 MORE AT CITATIONS TO THEIR PAPER 4284 03:28:09,720 --> 03:28:12,160 AND TO HOW MANY PAPERS ARE 4285 03:28:12,160 --> 03:28:12,800 PUBLISHED. 4286 03:28:12,800 --> 03:28:14,360 SO IF THERE IS EVIDENCE THAT 4287 03:28:14,360 --> 03:28:18,240 SHARING THE DATA INCREASES THE 4288 03:28:18,240 --> 03:28:21,440 IMPACT THROUGH CITATIONS IS AN 4289 03:28:21,440 --> 03:28:21,680 INCENTIVE. 4290 03:28:21,680 --> 03:28:23,320 AND THE THIRD ONE IS PRESSURE 4291 03:28:23,320 --> 03:28:26,480 FROM AGENCIES ARIZONA JOURNALS. 4292 03:28:26,480 --> 03:28:30,440 NIH HAS A SHARING MANDATE. 4293 03:28:30,440 --> 03:28:33,760 JOURNALS ARE REQUESTING THAT AND 4294 03:28:33,760 --> 03:28:35,560 REVIEWERS ARE REQUESTING THAT. 4295 03:28:35,560 --> 03:28:38,760 THAT'S AN INCH AT A TIME SHIFT 4296 03:28:38,760 --> 03:28:39,880 IN THE TIDE. 4297 03:28:39,880 --> 03:28:42,440 >>THE NOTION OF CHANGE HAPPENS 4298 03:28:42,440 --> 03:28:44,920 ONE RETIREMENT AT A TIME IS A 4299 03:28:44,920 --> 03:28:46,600 GOOD ONE AND I CERTAINLY 4300 03:28:46,600 --> 03:28:51,320 RESONATE WITH THAT. 4301 03:28:51,320 --> 03:28:52,640 EUN-YOUNG, DO YOU HAVE ANY 4302 03:28:52,640 --> 03:28:53,840 THOUGHTS ABOUT THAT. 4303 03:28:53,840 --> 03:28:56,320 SORT OF PERCEPTIONS AND 4304 03:28:56,320 --> 03:28:58,680 WILLINGNESS TO SHARE CHANGE OVER 4305 03:28:58,680 --> 03:29:00,800 TIME AND FOR INTEGRATE AND YOUR 4306 03:29:00,800 --> 03:29:01,480 WORK 4307 03:29:01,480 --> 03:29:02,040 >>YES. 4308 03:29:02,040 --> 03:29:05,760 I ECHO EVERYTHING. 4309 03:29:05,760 --> 03:29:08,760 I SAY THE GENERAL EXPECTATION 4310 03:29:08,760 --> 03:29:09,400 HAS SHIFTED. 4311 03:29:09,400 --> 03:29:13,160 BUT NONETHELESS WHEN SOMEBODY GO 4312 03:29:13,160 --> 03:29:14,960 AFTER INVESTIGATORS AND CLAIMS 4313 03:29:14,960 --> 03:29:16,840 THAT YOU ARE SUPPOSED TO SHARE 4314 03:29:16,840 --> 03:29:23,520 DATA IT'S REALLY NOT PLEASANT. 4315 03:29:23,520 --> 03:29:26,200 SO WE TRY TO PROMOTE GOOD 4316 03:29:26,200 --> 03:29:29,480 RELATIONSHIPS WITH EVERYBODY. 4317 03:29:29,480 --> 03:29:31,480 SO OF COURSE IT'S A MUCH SMALLER 4318 03:29:31,480 --> 03:29:31,880 SCALE. 4319 03:29:31,880 --> 03:29:38,880 BUT I TRY TO EMPHASIZE -- AND IT 4320 03:29:38,880 --> 03:29:40,600 HAS BEEN PRETTY GOOD. 4321 03:29:40,600 --> 03:29:42,960 AND GOING FORWARD WE THINK THAT 4322 03:29:42,960 --> 03:29:45,240 WE ONLY INCREASE. 4323 03:29:45,240 --> 03:29:51,600 BUT I ALSO AGREE WITH GEORGIO. 4324 03:29:51,600 --> 03:29:55,560 THERE HAS TO BE BETTER 4325 03:29:55,560 --> 03:29:57,000 INCENTIVES. 4326 03:29:57,000 --> 03:30:00,160 WHEN WE SHARE DATA IT TAKES A 4327 03:30:00,160 --> 03:30:02,160 LOT OF EFFORT TO SHARE DATA. 4328 03:30:02,160 --> 03:30:05,880 SO THERE HAS TO BE SOME BETTER 4329 03:30:05,880 --> 03:30:07,600 RECOMMENDATIONS FOR SHARING DATA 4330 03:30:07,600 --> 03:30:10,320 RATHER THAN JUST A REQUIREMENT. 4331 03:30:10,320 --> 03:30:13,720 >>WELL, THE NOTION GEORGIO, I 4332 03:30:13,720 --> 03:30:15,560 MENTIONED THE FACT THAT 4333 03:30:15,560 --> 03:30:17,240 CITATIONS CAN CHANGE TOO. 4334 03:30:17,240 --> 03:30:20,400 IT'S NOT JUST THE PUBLICATIONS. 4335 03:30:20,400 --> 03:30:23,080 7 PEOPLE ARE MORE AND MORE 4336 03:30:23,080 --> 03:30:26,240 COMING IN TUNE WITH. 4337 03:30:26,240 --> 03:30:33,320 DO YOU ISSUE -- DOIs FOR YOUR 4338 03:30:33,320 --> 03:30:34,120 DATA? 4339 03:30:34,120 --> 03:30:35,320 >>UPON REQUEST. 4340 03:30:35,320 --> 03:30:42,680 WE DON'T DO THAT SYSTEMATIC 4341 03:30:42,680 --> 03:30:44,960 CALY. 4342 03:30:44,960 --> 03:30:47,160 >>UPON REQUEST. 4343 03:30:47,160 --> 03:30:49,840 WE DO NOT DO IT BY DEFAULT 4344 03:30:49,840 --> 03:30:52,720 BECAUSE WE RELY ON THE LIBRARY 4345 03:30:52,720 --> 03:30:54,080 SERVICE OF GEORGE MASON 4346 03:30:54,080 --> 03:30:55,720 UNIVERSITY. 4347 03:30:55,720 --> 03:30:58,000 AND IT'S A COST SERVICE. 4348 03:30:58,000 --> 03:31:00,560 A SMALL TOKEN BUT WE CANNOT DO 4349 03:31:00,560 --> 03:31:04,120 IT SYSTEMATICALLY UNLESS IT 4350 03:31:04,120 --> 03:31:05,880 BECOMES A REQUIREMENT OR 4351 03:31:05,880 --> 03:31:08,520 CONSTANT REQUEST. 4352 03:31:08,520 --> 03:31:13,920 THEN WE WOULD HAVE TO ASK FOR 4353 03:31:13,920 --> 03:31:19,920 SUPPLEMENT REFUNDING. 4354 03:31:19,920 --> 03:31:20,560 *. 4355 03:31:20,560 --> 03:31:22,120 >>HERE IS A QUESTION I'M GOING 4356 03:31:22,120 --> 03:31:22,640 TO READ. 4357 03:31:22,640 --> 03:31:24,640 VERY INTERESTING WAYS TO 4358 03:31:24,640 --> 03:31:26,360 ILLUSTRATE COLLABORATION 4359 03:31:26,360 --> 03:31:26,960 AUTHORS. 4360 03:31:26,960 --> 03:31:29,040 HOW DO YOU HOPE THE IMAGE WILL 4361 03:31:29,040 --> 03:31:34,920 EVOLVE OVER THE NEXT FIVE YEARS? 4362 03:31:34,920 --> 03:31:39,800 >>I HOPE THAT THIS NETWORK SIZE 4363 03:31:39,800 --> 03:31:46,480 INCREASE FROM DIFFERENT SOURCES. 4364 03:31:46,480 --> 03:31:53,240 WE CAN SEE -- WE CAN COLOR IT 4365 03:31:53,240 --> 03:31:57,040 DIFFERENTLY BUT WE WANT TO 4366 03:31:57,040 --> 03:31:59,240 ORGANICALLY GROW AND GET MORE 4367 03:31:59,240 --> 03:32:01,240 COMPLEX AND WITH DIFFERENT 4368 03:32:01,240 --> 03:32:03,120 EXPERTISE COMING IN. 4369 03:32:03,120 --> 03:32:05,440 WE ACTIVELY COLLABORATE WITH 4370 03:32:05,440 --> 03:32:07,120 MANY INVESTIGATORS IN DIFFERENT 4371 03:32:07,120 --> 03:32:08,800 FIELDS AND IT HAS BEEN VERY, 4372 03:32:08,800 --> 03:32:10,560 VERY GOOD FOR THE PROJECT 4373 03:32:10,560 --> 03:32:11,920 INTEGRATE. 4374 03:32:11,920 --> 03:32:12,240 >>GREAT. 4375 03:32:12,240 --> 03:32:14,040 THANK YOU FOR THAT. 4376 03:32:14,040 --> 03:32:16,080 AND MAYBE WE HAVE A BIT OF TIME 4377 03:32:16,080 --> 03:32:18,640 SO I'M WONDERING HOW YOU EACH 4378 03:32:18,640 --> 03:32:24,840 LEARNED ABOUT THE PRIZE. 4379 03:32:24,840 --> 03:32:27,720 >>I HAVE LEARNED FROM MAILING 4380 03:32:27,720 --> 03:32:28,360 LISTS. 4381 03:32:28,360 --> 03:32:32,920 I ACTUALLY RECEIVED AN E-MAIL I 4382 03:32:32,920 --> 03:32:35,120 THINK DAYS AFTER THE PRIZE WAS 4383 03:32:35,120 --> 03:32:37,400 ANNOUNCED ORIGINALLY THROUGH A 4384 03:32:37,400 --> 03:32:41,840 PRESS RELEASE FROM NIH FASEB. 4385 03:32:41,840 --> 03:32:44,680 AS SOON AS I SAW IT I WAS LIKE 4386 03:32:44,680 --> 03:32:46,040 WOW! 4387 03:32:46,040 --> 03:32:48,520 BEFORE I EVEN REALIZED I SHOULD 4388 03:32:48,520 --> 03:32:49,600 APPLY TO THAT. 4389 03:32:49,600 --> 03:32:53,360 AND BEFORE CONTACTING MY TEAM 4390 03:32:53,360 --> 03:32:54,760 MEMBERS, WHAT DO YOU THINK. 4391 03:32:54,760 --> 03:32:57,240 IS THAT A GOOD FIT OR WHAT? 4392 03:32:57,240 --> 03:33:00,120 THE FIRST REACTION WAS ELATION. 4393 03:33:00,120 --> 03:33:02,480 THERE IS RECOGNITION FOR DATA 4394 03:33:02,480 --> 03:33:03,080 SHARING. 4395 03:33:03,080 --> 03:33:06,160 THAT IS REALLY GOOD BECAUSE PART 4396 03:33:06,160 --> 03:33:08,360 OF THE ISSUE FOR BOTH PEOPLE 4397 03:33:08,360 --> 03:33:11,640 SHARING DATA AND RESOURCE 4398 03:33:11,640 --> 03:33:15,320 PROVIDERS THAT CREATE THE 4399 03:33:15,320 --> 03:33:17,720 MEDIUMS IT'S A LIKE OBSCURE 4400 03:33:17,720 --> 03:33:20,160 BEHIND THE CURTAINS WORK. 4401 03:33:20,160 --> 03:33:23,800 IT'S NOT THE SAME AS DISCOVERY 4402 03:33:23,800 --> 03:33:28,600 SCIENCE. 4403 03:33:28,600 --> 03:33:30,880 VERY CLEAR FRONT SCIENCE. 4404 03:33:30,880 --> 03:33:32,920 SO THE FACT THAT THERE WAS A 4405 03:33:32,920 --> 03:33:36,960 MOVEMENT IN THAT REGARD IT WAS 4406 03:33:36,960 --> 03:33:39,600 VERY, VERY PLEASING I HAVE TO 4407 03:33:39,600 --> 03:33:40,920 SAY. 4408 03:33:40,920 --> 03:33:45,120 AND THEN IT TOOK A LITTLE BIT TO 4409 03:33:45,120 --> 03:33:49,840 SAY -- WE WOULD BE A GOOD 4410 03:33:49,840 --> 03:33:51,440 CANDIDATE FOR THIS AND WITHIN 4411 03:33:51,440 --> 03:33:53,960 DAYS OF CONTACTING MY TEAM 4412 03:33:53,960 --> 03:33:56,280 MEMBERS I STARTED RECEIVING 4413 03:33:56,280 --> 03:33:58,960 DOZENS OF SPONTANEOUS E-MAILS 4414 03:33:58,960 --> 03:34:00,960 FROM COLLEAGUES OR DATA 4415 03:34:00,960 --> 03:34:03,480 PROVIDERS OR DATA USERS SAYING 4416 03:34:03,480 --> 03:34:05,480 THERE IS THIS OPPORTUNITY HERE. 4417 03:34:05,480 --> 03:34:07,800 YOU GUYS SHOULD DEFINITELY DO 4418 03:34:07,800 --> 03:34:09,120 IT. 4419 03:34:09,120 --> 03:34:12,120 SO THAT WAS REINFORCING. 4420 03:34:12,120 --> 03:34:13,360 >>I HEAR YOU. 4421 03:34:13,360 --> 03:34:17,240 IT CERTAINLY CAN BE CAN FEEL 4422 03:34:17,240 --> 03:34:23,080 LIKE AN ALTRUISTIC ENDEAVOR TO 4423 03:34:23,080 --> 03:34:27,080 SUPPORT NEURO MORPHO FROM THE 4424 03:34:27,080 --> 03:34:29,400 INSIDE -- BUT THE BENEFITS ARE 4425 03:34:29,400 --> 03:34:34,240 BECOMING MORE AND MORE MORE APP. 4426 03:34:34,240 --> 03:34:36,640 EUN-YOUNG FROM YOUR SIDE, HOW 4427 03:34:36,640 --> 03:34:40,320 DID YOU LEARN ABOUT THE PROJECT? 4428 03:34:40,320 --> 03:34:42,400 >>I ALSO RECEIVED AN E-MAIL BUT 4429 03:34:42,400 --> 03:34:44,440 I DON'T KNOW FROM WHO. 4430 03:34:44,440 --> 03:34:48,600 AND I WAS THINKING THIS IS AS 4431 03:34:48,600 --> 03:34:52,360 YOU STATED -- REUSE AND SHARE 4432 03:34:52,360 --> 03:34:53,360 THE DATA. 4433 03:34:53,360 --> 03:34:54,560 THIS IS IT. 4434 03:34:54,560 --> 03:35:02,280 WE COMPETED FOR DATA REUSE. 4435 03:35:02,280 --> 03:35:06,880 AND I GUESS IN RESPONSE TO THE 4436 03:35:06,880 --> 03:35:09,840 PREVIOUS COMMENT, WE SHARED DATA 4437 03:35:09,840 --> 03:35:12,800 IN GENERAL REPOSITORY AND THEY 4438 03:35:12,800 --> 03:35:17,720 HAVE A DUI PROVIDED FOR EACH. 4439 03:35:17,720 --> 03:35:22,920 SO WE HAVE SO FAR 10 DATASETS 4440 03:35:22,920 --> 03:35:29,080 UPLOADED WITH THE CODE AND THE 4441 03:35:29,080 --> 03:35:32,640 FUNCTIONALITY IN THE GENERAL 4442 03:35:32,640 --> 03:35:34,120 REPOSITORIES AND MY EXPERIENCE 4443 03:35:34,120 --> 03:35:36,400 HAS BEEN PRETTY PLEASANT. 4444 03:35:36,400 --> 03:35:38,960 >>THE CHALLENGE IS DOING THAT 4445 03:35:38,960 --> 03:35:41,080 AT SCALE WHICH IS GEORGIO'S 4446 03:35:41,080 --> 03:35:41,520 ISSUE. 4447 03:35:41,520 --> 03:35:43,680 YOUR DATASETS ARE QUITE 4448 03:35:43,680 --> 03:35:46,120 DIFFERENT IN THAT THEY ARE QUITE 4449 03:35:46,120 --> 03:35:48,000 HIGH VALUE INTELLECTUALLY AND 4450 03:35:48,000 --> 03:35:49,920 TAKE A LOT OF TIME TO GET TO 4451 03:35:49,920 --> 03:35:52,440 WHAT YOU'RE SHARING. 4452 03:35:52,440 --> 03:35:54,040 FEWER BUT VERY HIGH VALUE. 4453 03:35:54,040 --> 03:35:56,920 7 AND SO, ITS EASIER TO IMAGINE 4454 03:35:56,920 --> 03:35:57,600 THAT. 4455 03:35:57,600 --> 03:36:01,200 WHEN YOU HAVE TENS OF THOUSANDS 4456 03:36:01,200 --> 03:36:03,000 CURRENTLY THE WAY THEY ARE 4457 03:36:03,000 --> 03:36:05,080 ISSUED IS TOO LABOR-INTENSIVE. 4458 03:36:05,080 --> 03:36:06,920 THAT IS SOMETHING THAT MAY NEED 4459 03:36:06,920 --> 03:36:08,640 TO BE CONSIDERED GOING FORWARD. 4460 03:36:08,640 --> 03:36:14,160 HOW WE DO CREATE THAT PERMANENT 4461 03:36:14,160 --> 03:36:16,600 IDENTIFIER AT SCALE HOW WOULD 4462 03:36:16,600 --> 03:36:19,800 YOU DO THAT ACROSS TENS OF 4463 03:36:19,800 --> 03:36:21,440 THOUSANDS OF ENTRIES IS AN 4464 03:36:21,440 --> 03:36:22,160 ISSUE. 4465 03:36:22,160 --> 03:36:24,000 IT'S QUITE INTERESTING, WE HAVE 4466 03:36:24,000 --> 03:36:24,960 A FEW MINUTES LEFT. 4467 03:36:24,960 --> 03:36:27,440 I THINK THAT IS ALL THE 4468 03:36:27,440 --> 03:36:32,040 QUESTIONS THAT WERE IN THE CHAT. 4469 03:36:32,040 --> 03:36:38,080 SO ONE OF THE QUESTIONS WAS HOW 4470 03:36:38,080 --> 03:36:42,680 TO ADDRESS THE QUESTION OF OPEN 4471 03:36:42,680 --> 03:36:44,280 PUBLICATION FEES. 4472 03:36:44,280 --> 03:36:47,680 SOMEONE IS ASKING ABOUT HOW WE 4473 03:36:47,680 --> 03:36:50,440 MIGHT MANAGE THOSE ISSUES. 4474 03:36:50,440 --> 03:36:53,000 AND THE YEAR OF OPEN SCIENCE AND 4475 03:36:53,000 --> 03:36:55,360 OPEN PUBLICATIONS OF COURSE WE 4476 03:36:55,360 --> 03:36:56,840 CREATE NEW BARRIERS. 4477 03:36:56,840 --> 03:37:00,600 IN THE VERY OLD DAYS OF 4478 03:37:00,600 --> 03:37:03,040 PUBLICATIONS YOU KNOW IT WAS A 4479 03:37:03,040 --> 03:37:05,240 SUBSCRIBER MODEL. 4480 03:37:05,240 --> 03:37:09,640 SUBSCRIBERS PAID FOR THE FEE. 4481 03:37:09,640 --> 03:37:12,720 WHEN WE MOVED TO OPEN ACCESS WE 4482 03:37:12,720 --> 03:37:15,880 CREATED A PRODUCER'S FEE. 4483 03:37:15,880 --> 03:37:18,040 THOSE THAT PRODUCE THE DATA PAY 4484 03:37:18,040 --> 03:37:20,320 THE MONEY SO WE'VE SHIFTED WHO'S 4485 03:37:20,320 --> 03:37:21,800 PAYING AND SOMETIMES THAT IS A 4486 03:37:21,800 --> 03:37:24,520 BARRIER. 4487 03:37:24,520 --> 03:37:26,400 THE NOTION OF OPEN SCIENCE AND 4488 03:37:26,400 --> 03:37:27,600 OPEN PUBLICATION. 4489 03:37:27,600 --> 03:37:30,280 FOR THOSE WHO HAVE TROUBLE 4490 03:37:30,280 --> 03:37:32,480 FINDING THOSE FEES AND WHEN YOU 4491 03:37:32,480 --> 03:37:34,360 COME BACK I MENTIONED THE 4492 03:37:34,360 --> 03:37:36,200 DEVELOPING WORLD AND HOW 4493 03:37:36,200 --> 03:37:37,600 CRITICAL IT SEEMS TO BE THAT 4494 03:37:37,600 --> 03:37:40,040 EVEN THOUGH IT COSTS TREMENDOUS 4495 03:37:40,040 --> 03:37:41,920 AMOUNTS OF MONEY TO HAVE THE 4496 03:37:41,920 --> 03:37:44,600 PLATFORMS TO CREATE THE DATA 4497 03:37:44,600 --> 03:37:46,600 THAT IT'S BEING USED BY THOSE 4498 03:37:46,600 --> 03:37:47,920 OTHER AREAS OF THE WORLD. 4499 03:37:47,920 --> 03:37:50,360 IT'S THE SAME THING IN TERMS OF 4500 03:37:50,360 --> 03:37:52,440 THOSE OPEN FEES. 4501 03:37:52,440 --> 03:37:55,280 SO, THAT IS CERTAINLY AN ISSUE. 4502 03:37:55,280 --> 03:37:57,760 I SORT OF TALKED TO THAT ONE. 4503 03:37:57,760 --> 03:37:59,720 IT WAS MORE OF A DISCUSSION 4504 03:37:59,720 --> 03:38:01,680 POINT. 4505 03:38:01,680 --> 03:38:06,840 GEORGIO, HOW DOES NEURO MORP 4506 03:38:06,840 --> 03:38:08,160 MORPHO.ORG KEEP TRACK OF THE 4507 03:38:08,160 --> 03:38:08,600 TRENDS. 4508 03:38:08,600 --> 03:38:10,640 DO YOU GOES WITH WHAT HAPPENS? 4509 03:38:10,640 --> 03:38:15,200 DO YOU SEE WHAT HAPPENS? 4510 03:38:15,200 --> 03:38:17,480 IT'S ALL TECHNOLOGY DRIVEN. 4511 03:38:17,480 --> 03:38:20,360 >>WE USED TO DO IT THE OLD 4512 03:38:20,360 --> 03:38:22,440 FASHIONED WAY. 4513 03:38:22,440 --> 03:38:25,960 PubMed SEARCHES AND EXCEL 4514 03:38:25,960 --> 03:38:26,720 SPREADSHEETS. 4515 03:38:26,720 --> 03:38:29,400 IT WAS NOT SUSTAINABLE IN PART 4516 03:38:29,400 --> 03:38:30,520 BECAUSE OF THE SCALE. 4517 03:38:30,520 --> 03:38:32,800 IT DOESN'T REALLY SCALE. 4518 03:38:32,800 --> 03:38:35,680 THE QUALITY CONTROL ON THAT IS 4519 03:38:35,680 --> 03:38:37,360 QUITE DIFFICULT TO UPHOLD. 4520 03:38:37,360 --> 03:38:41,760 7 WE NOW MOVE TO BASICALLY 4521 03:38:41,760 --> 03:38:43,560 MACHINE LEARNING TECHNOLOGIES 4522 03:38:43,560 --> 03:38:47,200 THAT WE CUSTOM DEVELOPED 4523 03:38:47,200 --> 03:38:50,960 LEVERAGING APPLICATION 4524 03:38:50,960 --> 03:38:53,320 PROGRAMMERS INTERFACE FROM ALL 4525 03:38:53,320 --> 03:38:54,960 MAJOR PUBLISHERS. 4526 03:38:54,960 --> 03:38:58,600 SO NOW WE CAN THROW CONTINUOUS 4527 03:38:58,600 --> 03:39:00,840 LITERATURE SEARCHES USING KEY 4528 03:39:00,840 --> 03:39:03,360 WORDS SO CASTING THE NET VERY 4529 03:39:03,360 --> 03:39:04,120 WIDE. 4530 03:39:04,120 --> 03:39:08,080 AND THEN WE HAVE A VERY NICE 4531 03:39:08,080 --> 03:39:10,640 FULL TEXT DEEP LEARNING MODEL 4532 03:39:10,640 --> 03:39:13,960 THAT DOES A PRETTY GOOD JOB AT 4533 03:39:13,960 --> 03:39:17,240 CATALOGING WHICH PAPERS MIGHT 4534 03:39:17,240 --> 03:39:18,800 CONTAIN INTEREST. 4535 03:39:18,800 --> 03:39:20,200 ULTIMATELY YOU NEED HUMANS TO 4536 03:39:20,200 --> 03:39:22,880 LOOK AT THE PAPERS AND DETERMINE 4537 03:39:22,880 --> 03:39:25,760 IF IT IS REAL OR NOT BUT IF YOU 4538 03:39:25,760 --> 03:39:30,520 DO IT FOR A FEW DOES PAPERS A 4539 03:39:30,520 --> 03:39:32,080 WEEK IT'S DOABLE AND YOU CAN 4540 03:39:32,080 --> 03:39:34,680 START WITH HUNDREDS OF THOUSANDS 4541 03:39:34,680 --> 03:39:38,240 OF PUBLICATIONS THEN IT'S NOT 4542 03:39:38,240 --> 03:39:38,920 DOABLE. 4543 03:39:38,920 --> 03:39:41,760 8 DOMAIN EXPERTISE AND HUMAN 4544 03:39:41,760 --> 03:39:44,760 KNOWLEDGE AND SOME BRUTE FORCE 4545 03:39:44,760 --> 03:39:47,560 MACHINE CRANKING UNDERNEATH. 4546 03:39:47,560 --> 03:39:48,720 >>GOT IT. 4547 03:39:48,720 --> 03:39:51,120 WE'RE JUST ABOUT OUT OF TIME. 4548 03:39:51,120 --> 03:39:53,760 IT WAS INSIGHTFUL. 4549 03:39:53,760 --> 03:39:55,840 VERY DIFFERENT KINDS OF 4550 03:39:55,840 --> 03:39:58,360 PLATFORMS BUT IN EACH CASE DATA 4551 03:39:58,360 --> 03:40:00,040 SHARING HAS BEEN CRITICAL AND 4552 03:40:00,040 --> 03:40:02,120 IT'S GREAT TO SEE THE 4553 03:40:02,120 --> 03:40:02,560 TRANSITIONS. 4554 03:40:02,560 --> 03:40:06,960 AND HOPEFULLY WE'LL SEE IT 4555 03:40:06,960 --> 03:40:08,960 CONTINUE. 4556 03:40:08,960 --> 03:40:13,680 I'M NOW GOING TO TRANSITION TO 4557 03:40:13,680 --> 03:40:15,280 YVETTE SEGER. 4558 03:40:15,280 --> 03:40:18,960 >>THANK YOU, PARKER. 4559 03:40:18,960 --> 03:40:21,640 THANK YOU ALL FOR JOINING US FOR 4560 03:40:21,640 --> 03:40:24,880 DAY ONE. 4561 03:40:24,880 --> 03:40:26,720 TODAY'S PANEL FEATURES A RANGE 4562 03:40:26,720 --> 03:40:34,760 OF OUTSTANDING RESEARCH. 4563 03:40:34,760 --> 03:40:37,080 I WANT TO THANK ALL OF TODAY'S 4564 03:40:37,080 --> 03:40:38,480 PRESENTERS FORGIVE APPROXIMATING 4565 03:40:38,480 --> 03:40:40,560 US A WINDOW INTO THEIR 4566 03:40:40,560 --> 03:40:42,160 INCREDIBLE TEAM EFFORTS AND I 4567 03:40:42,160 --> 03:40:44,480 APPRECIATED SO MANY OF THEM 4568 03:40:44,480 --> 03:40:45,440 SHOWING THEIR TEAM MEMBERS. 4569 03:40:45,440 --> 03:40:49,240 7 AND AS WELL AS OUR MODERATORS 4570 03:40:49,240 --> 03:40:52,000 FOR SHEPPARDING US THROUGH THE 4571 03:40:52,000 --> 03:40:52,440 CONVERSATIONS. 4572 03:40:52,440 --> 03:40:55,560 I WANT TO THANK OUR AUDIENCE FOR 4573 03:40:55,560 --> 03:40:56,640 THEIR THOUGHTFUL QUESTIONS 4574 03:40:56,640 --> 03:40:57,400 THROUGHOUT THE DAY. 4575 03:40:57,400 --> 03:41:00,400 WE HOPE THAT MANY OF YOU WILL 4576 03:41:00,400 --> 03:41:02,760 JOIN US TOMORROW FOR DAY TWO 4577 03:41:02,760 --> 03:41:08,240 WHICH WILL FEATURE THREE MORE 4578 03:41:08,240 --> 03:41:13,800 PANELS. 4579 03:41:13,800 --> 03:41:16,160 SHOULD BE ANOTHER EXCITING DAY. 4580 03:41:16,160 --> 03:41:19,400 WE'LL GET STARTED AT 11:00 A.M. 4581 03:41:19,400 --> 03:41:21,160 EASTERN AND THE SESSION WILL BE 4582 03:41:21,160 --> 03:41:22,760 LIVE STREAMED ON THE NIH VIDEO 4583 03:41:22,760 --> 03:41:23,320 CAST. 4584 03:41:23,320 --> 03:41:25,160 BEFORE WE LOG OFF FOR THE DAY I 4585 03:41:25,160 --> 03:41:28,400 WANT TO ACKNOWLEDGE OUR 4586 03:41:28,400 --> 03:41:29,000 COLLEAGUES IN THE NIH WAS OF 4587 03:41:29,000 --> 03:41:39,400 DATA SCIENCE STRATEGY. 4588 03:41:52,320 --> 03:41:54,600 HOPE TO SEE MANY OF YOU TOMORROW 4589 03:41:54,600 --> 03:42:05,000 AND THANK YOU SO MUCH.