1 00:00:06,086 --> 00:00:07,087 >> GOOD MORNING, EVERYONE. 2 00:00:07,087 --> 00:00:09,256 I'M NORA VOLKOW, DIRECTOR OF 3 00:00:09,256 --> 00:00:09,923 NATIONAL INSTITUTE ON DRUG 4 00:00:09,923 --> 00:00:10,157 ABUSE. 5 00:00:10,157 --> 00:00:12,225 IT'S A PLEASURE TO BE BY THE 6 00:00:12,225 --> 00:00:13,860 SIDE OF MY COLLEAGUE AND FRIEND 7 00:00:13,860 --> 00:00:15,729 DR. GEORGE KOOB WHO OF COURSE 8 00:00:15,729 --> 00:00:17,898 NEEDS NO INTRODUCTION BUT HE'S 9 00:00:17,898 --> 00:00:18,665 THE DIRECTOR OF THE NATIONAL 10 00:00:18,665 --> 00:00:20,100 INSTITUTE OF ALCOHOL ABUSE AND 11 00:00:20,100 --> 00:00:20,534 ALCOHOLISM. 12 00:00:20,534 --> 00:00:22,936 SO FIRST OF ALL I WANT TO THANK 13 00:00:22,936 --> 00:00:24,571 EVERYONE BOTH FROM THE COUNCIL 14 00:00:24,571 --> 00:00:35,048 OF THE NATIONAL IN NATIONAL 15 00:00:36,917 --> 00:00:39,152 INSTITUTE OF ALCOHOLISM AND DRUG 16 00:00:39,152 --> 00:00:40,587 ABUSE FOR BEING HERE. 17 00:00:40,587 --> 00:00:41,988 THIS IS AN OPPORTUNITY FOR 18 00:00:41,988 --> 00:00:44,724 PEOPLE ON TWO COUNCILS TO GET 19 00:00:44,724 --> 00:00:46,226 TOGETHER, IT'S AN EVENT THAT 20 00:00:46,226 --> 00:00:47,461 ONLY HAPPENS ONE YEAR. 21 00:00:47,461 --> 00:00:50,864 I LOOK FORWARD TO IT AND I'M 22 00:00:50,864 --> 00:00:53,400 INTERESTED ON SEEING HOW COUNCIL 23 00:00:53,400 --> 00:01:01,041 MEMBERS FROM THE NIAAA REACT TO 24 00:01:01,041 --> 00:01:03,009 OUR SIDE AND THE OTHER WAY 25 00:01:03,009 --> 00:01:04,277 AROUND, ADDICTION SAN ADDICTION. 26 00:01:04,277 --> 00:01:05,946 BEFORE WE START I THINK IT IS 27 00:01:05,946 --> 00:01:07,914 IMPORTANT FOR ALL OF US AS WE 28 00:01:07,914 --> 00:01:11,418 DON'T NECESSARILY KNOW EACH 29 00:01:11,418 --> 00:01:19,626 OTHER, TO INTRODUCE ONESELF. 30 00:01:19,626 --> 00:01:23,230 >> GEORGE KOOB, DIRECTOR OF NIAA 31 00:01:23,230 --> 00:01:31,471 >> TRISH, DEPUTY DIRECTOR AT 32 00:01:31,471 --> 00:01:32,339 NIAA. 33 00:01:32,339 --> 00:01:34,074 >> PHILIPPE MARMILLOT. 34 00:01:34,074 --> 00:01:34,774 >> RHONDA JONES-WEBB, UNIVERSITY 35 00:01:34,774 --> 00:01:42,749 OF MINNESOTA SCHOOL OF PUBLIC 36 00:01:42,749 --> 00:01:43,750 HEALTH. 37 00:01:43,750 --> 00:01:44,518 >> REGINA LABELLE, GEORGETOWN 38 00:01:44,518 --> 00:01:50,457 UNIVERSITY, ADVISORY BOARD FOR 39 00:01:50,457 --> 00:01:50,657 NIDA. 40 00:01:50,657 --> 00:01:51,157 >> MICHAEL LEWIS, CITY 41 00:01:51,157 --> 00:01:55,729 UNIVERSITY OF NEW YORK AND 42 00:01:55,729 --> 00:02:00,634 HUNTER COLLEGE, NIAA COUNCIL. 43 00:02:00,634 --> 00:02:02,469 >> UNIVERSITY SCHOOL OF 44 00:02:02,469 --> 00:02:04,104 MEDICINE, NIDA COUNCIL. 45 00:02:04,104 --> 00:02:07,407 >> HAIDEN HUSKAMP, DEPARTMENT OF 46 00:02:07,407 --> 00:02:08,708 HEALTH CARE POLICY HARVARD 47 00:02:08,708 --> 00:02:14,981 MEDICAL SCHOOL, NIAA COUNCIL. 48 00:02:14,981 --> 00:02:18,585 >> SHELLY GREENFIELD, NIDA 49 00:02:18,585 --> 00:02:18,818 COUNCIL. 50 00:02:18,818 --> 00:02:29,229 >> GOOD MORNING, KATIE 51 00:02:29,596 --> 00:02:35,101 WITKIEWITZ NIAA COUNCIL. 52 00:02:35,101 --> 00:02:38,038 >> DANE MAYFIELD, UNIVERSITY OF 53 00:02:38,038 --> 00:02:41,575 TEXAS AUSTIN. 54 00:02:41,575 --> 00:02:43,643 >> ANNA ROSE CHILDRESS, NIDA 55 00:02:43,643 --> 00:02:44,077 COUNCIL. 56 00:02:44,077 --> 00:02:46,379 >> TINA CHAMBERS, UNIVERSITY OF 57 00:02:46,379 --> 00:02:50,183 CALIFORNIA SAN DIEGO, NIAA 58 00:02:50,183 --> 00:02:53,587 COUNCIL. 59 00:02:53,587 --> 00:02:56,356 >> GOOD MORNING, KATE DEBURNY, 60 00:02:56,356 --> 00:03:04,230 CONSULTANT, NIDA COUNCIL. 61 00:03:04,230 --> 00:03:06,132 >> DAVID KAREKEN, INDIANA 62 00:03:06,132 --> 00:03:08,868 UNIVERSITY SCHOOL OF MEDICINE. 63 00:03:08,868 --> 00:03:10,136 >> COLUMBIA UNIVERSITY, NIDA 64 00:03:10,136 --> 00:03:10,604 COUNCIL. 65 00:03:10,604 --> 00:03:12,105 >> GOOD MORNING, BILL CLINE, 66 00:03:12,105 --> 00:03:15,075 ASSOCIATE DIRECTOR OF BEHAVIORAL 67 00:03:15,075 --> 00:03:19,546 RESEARCH NATIONAL CANCER 68 00:03:19,546 --> 00:03:19,813 INSTITUTE. 69 00:03:19,813 --> 00:03:20,347 >> SUSAN WEISS, NATIONAL 70 00:03:20,347 --> 00:03:23,316 INSTITUTE ON DRUG ABUSE, 71 00:03:23,316 --> 00:03:29,322 DIRECTOR OF EXTRAMURAL RESEARCH. 72 00:03:29,322 --> 00:03:29,956 >> WILSON COMPTON, NATIONAL 73 00:03:29,956 --> 00:03:31,558 INSTITUTE ON DRUG ABUSE. 74 00:03:31,558 --> 00:03:33,727 >> GOOD MORNING, I'M GOING TO GO 75 00:03:33,727 --> 00:03:35,629 INTO THE SCREENS IN THE CLOUD. 76 00:03:35,629 --> 00:03:37,697 SO I'M GOING GIVE YOUR NAME AND 77 00:03:37,697 --> 00:03:39,566 IF YOU CAN JUST SHOW AND SAY 78 00:03:39,566 --> 00:03:48,108 HELLO SO WE CAN ALL RECOGNIZE 79 00:03:48,108 --> 00:03:51,611 EACH OTHER. 80 00:03:51,611 --> 00:03:54,981 DR. ASSAD MILLHOFFER. 81 00:03:54,981 --> 00:03:57,617 I DON'T SEE -- I'M GOING TO THE 82 00:03:57,617 --> 00:04:00,787 NEXT PERSON. 83 00:04:00,787 --> 00:04:04,758 DR. NANCY BARNETT. 84 00:04:04,758 --> 00:04:07,594 >> BROWN UNIVERSITY, NIAA 85 00:04:07,594 --> 00:04:07,994 COUNCIL. 86 00:04:07,994 --> 00:04:11,698 >> DR. RICHARD BOXER. 87 00:04:11,698 --> 00:04:13,700 >> GOOD MORNING, UCLA MEDICAL 88 00:04:13,700 --> 00:04:18,204 CENTER, NATIONAL CANCER ADVISORY 89 00:04:18,204 --> 00:04:18,405 BOARD. 90 00:04:18,405 --> 00:04:21,141 >> DR. ANDREW CAMERON. 91 00:04:21,141 --> 00:04:21,941 >> HI, ANDREW CAMERON, 92 00:04:21,941 --> 00:04:24,944 TRANSPLANT SURGEON JOHNS HOPKINS 93 00:04:24,944 --> 00:04:28,481 ON THE COUNCIL. 94 00:04:28,481 --> 00:04:33,953 >> DR. JOHN COMPTON. 95 00:04:33,953 --> 00:04:38,024 >> JOHN COMPTON, CANCER CENTER, 96 00:04:38,024 --> 00:04:42,395 CURRENT CHAIR FOR (INAUDIBLE) 97 00:04:42,395 --> 00:04:42,962 REPORT. 98 00:04:42,962 --> 00:04:46,566 >> DR. DEBRA CHASLER. 99 00:04:46,566 --> 00:04:47,734 >> GOOD MORNING, BOSTON 100 00:04:47,734 --> 00:04:54,207 UNIVERSITY, ON THE NIDA COUNCIL. 101 00:04:54,207 --> 00:04:55,975 >> DR. CHARLES CHATKIN. 102 00:04:55,975 --> 00:05:00,780 >> UNIVERSITY OF WASHINGTON, 103 00:05:00,780 --> 00:05:01,548 NIDA COUNCIL. 104 00:05:01,548 --> 00:05:02,649 >> DENNIS DEER. 105 00:05:02,649 --> 00:05:07,387 HE'S NOT UP THERE. 106 00:05:07,387 --> 00:05:09,723 HE'S NIDA COUNCIL. 107 00:05:09,723 --> 00:05:13,827 DR. LUIS DIAZ? 108 00:05:13,827 --> 00:05:14,794 >> YEAH, MEMORIAL 109 00:05:14,794 --> 00:05:21,267 SLOAN-KETTERING, NCAB. 110 00:05:21,267 --> 00:05:22,135 >> ISABELLE DURON. 111 00:05:22,135 --> 00:05:32,579 I DON'T THINK SHE'S THERE. 112 00:05:35,682 --> 00:05:38,651 ANIT NET KIN, NOT THERE. 113 00:05:38,651 --> 00:05:40,420 HOWARD FINGERT. 114 00:05:40,420 --> 00:05:44,791 >> HELLO, HOWARD FINGERT, 115 00:05:44,791 --> 00:05:47,560 HEMATOLOGIST ONCOLOGIST, ONO 116 00:05:47,560 --> 00:05:51,798 PHARMACEUTICALS, ON THE NCAB. 117 00:05:51,798 --> 00:05:52,565 >> JULIE GRANT. 118 00:05:52,565 --> 00:05:55,168 >> HELLO, NICE TO MEET YOU, 119 00:05:55,168 --> 00:06:01,841 GENERAL PARTNER AT VENTURE FUND, 120 00:06:01,841 --> 00:06:04,911 CANAAN, A SMALL START-UP BIOTECH 121 00:06:04,911 --> 00:06:11,050 ONCOLOGY COMPANY, NCAB. 122 00:06:11,050 --> 00:06:12,252 >> DR. HAIMY HAMBURGER. 123 00:06:12,252 --> 00:06:13,453 >> NORTHWESTERN UNIVERSITY, 124 00:06:13,453 --> 00:06:19,058 NATIONAL CANCER BOARD. 125 00:06:19,058 --> 00:06:22,896 >> DR. KA TIBI. 126 00:06:22,896 --> 00:06:29,769 I DON'T THINK SHE'S THERE. 127 00:06:29,769 --> 00:06:31,304 DR. ANGELA LAIRD. 128 00:06:31,304 --> 00:06:34,374 >> FLORIDA INTERNATIONAL 129 00:06:34,374 --> 00:06:41,915 UNIVERSITY, NIDA COUNCIL. 130 00:06:41,915 --> 00:06:43,149 >> DR. FRANCES LEVIN. 131 00:06:43,149 --> 00:06:50,456 >> SHE'S NOT, THERE NIDA 132 00:06:50,456 --> 00:06:50,690 COUNCIL. 133 00:06:50,690 --> 00:06:52,759 DR. ANNA NAVAS-ACIEN. 134 00:06:52,759 --> 00:06:53,960 >> GOOD MORNING, COLUMBIA 135 00:06:53,960 --> 00:06:55,195 UNIVERSITY, HEALTH SCIENCES, 136 00:06:55,195 --> 00:06:59,866 MEMBER OF THE NATIONAL CANCER 137 00:06:59,866 --> 00:07:04,370 ADVISORY BOARD. 138 00:07:04,370 --> 00:07:05,471 >> DR. ANDREW OSTROWSKI. 139 00:07:05,471 --> 00:07:08,308 I DON'T THINK HE'S THERE. 140 00:07:08,308 --> 00:07:15,849 HE'S NIDA COUNCIL. 141 00:07:15,849 --> 00:07:16,950 DR. MELANIE OTT. 142 00:07:16,950 --> 00:07:24,157 SHE'S NOT THERE. 143 00:07:24,157 --> 00:07:25,358 DR. TRAVIS RYDER. 144 00:07:25,358 --> 00:07:29,729 HE'S NIDA COUNCIL, HE'S NOT 145 00:07:29,729 --> 00:07:31,831 THERE. 146 00:07:31,831 --> 00:07:33,566 DR. FRED TABUNG. 147 00:07:33,566 --> 00:07:35,101 >> HI, OHIO STATE UNIVERSITY, 148 00:07:35,101 --> 00:07:36,836 COLLEGE OF MEDICINE AND 149 00:07:36,836 --> 00:07:38,271 COMPREHENSIVE CANCER CENTER, 150 00:07:38,271 --> 00:07:43,610 WITH THE NATIONAL CANCER 151 00:07:43,610 --> 00:07:49,349 ADVISORY BOARD. 152 00:07:49,349 --> 00:07:51,251 >> DR. VON ZASTROW. 153 00:07:51,251 --> 00:07:54,821 >> UNIVERSITY OF CALIFORNIA, SAN 154 00:07:54,821 --> 00:07:55,855 FRANCISCO. 155 00:07:55,855 --> 00:08:00,526 >> NIDA COUNCIL. 156 00:08:00,526 --> 00:08:02,495 >> NIDA COUNCIL. 157 00:08:02,495 --> 00:08:07,734 >> I'M TERRITORIAL, I'M SORRY. 158 00:08:07,734 --> 00:08:08,968 DR. MELISSA WELLS. 159 00:08:08,968 --> 00:08:10,069 SHE'S NOT THERE. 160 00:08:10,069 --> 00:08:12,772 SHE'S NIDA. 161 00:08:12,772 --> 00:08:20,246 AND THEN WE HAVE DR. KAREN WINK 162 00:08:20,246 --> 00:08:21,414 FIELD. 163 00:08:21,414 --> 00:08:24,784 >> KAREN WINK FIELD, RADIATION 164 00:08:24,784 --> 00:08:25,485 ONCOLOGIST VANDERBILT, NATIONAL 165 00:08:25,485 --> 00:08:26,019 CANCER BOARD. 166 00:08:26,019 --> 00:08:27,620 >> THANKS VERY MUCH. 167 00:08:27,620 --> 00:08:30,657 ANYONE ELSE THAT WE MISSED? 168 00:08:30,657 --> 00:08:32,625 IF NOT I THANK VERY MUCH FOR 169 00:08:32,625 --> 00:08:36,562 YOUR WILLINGNESS TO BE PART OF 170 00:08:36,562 --> 00:08:37,764 OUR COUNCILS AND BEING HERE 171 00:08:37,764 --> 00:08:38,097 TODAY. 172 00:08:38,097 --> 00:08:41,701 I'M GOING TO GIVE THE NIDA 173 00:08:41,701 --> 00:08:42,669 DIRECTOR'S REPORT FOR CRAN FROM 174 00:08:42,669 --> 00:08:53,146 OVER THERE IF THAT'S OKAY. 175 00:09:12,966 --> 00:09:15,068 I GAVE A REPORT YESTERDAY AND 176 00:09:15,068 --> 00:09:17,236 SAID IT'S A GREAT TIME TO 177 00:09:17,236 --> 00:09:18,471 PREPARE BECAUSE IT FORCES ME TO 178 00:09:18,471 --> 00:09:22,508 LOOK AT WHAT WE'VE DONE EVERY 179 00:09:22,508 --> 00:09:23,476 FOUR MONTHS FOR COUNCIL, FOR 180 00:09:23,476 --> 00:09:28,314 CRAN TO TRY TO IDENTIFY TOPICS 181 00:09:28,314 --> 00:09:38,825 PARTICULARLY SALIENT NIDA AND 182 00:09:39,559 --> 00:09:42,562 NIAAA, NOT WANTING TO DISCUSS 183 00:09:42,562 --> 00:09:43,896 THINGS DISCUSSED YESTERDAY IN 184 00:09:43,896 --> 00:09:45,231 NIDA COUNCIL. 185 00:09:45,231 --> 00:09:49,369 NOT ALWAYS SUCCESSFUL BUT TRY TO 186 00:09:49,369 --> 00:09:49,969 DO MY BEST. 187 00:09:49,969 --> 00:10:00,513 WHAT I LIKE TO DO AT CRAN FIRST 188 00:10:00,813 --> 00:10:04,917 OF ALL GET PERSPECTIVE OF 189 00:10:04,917 --> 00:10:06,786 ANYTHING IN THE FIELD AND WE 190 00:10:06,786 --> 00:10:09,722 HAVE BEEN WITHOUT A DIRECTOR OF 191 00:10:09,722 --> 00:10:11,257 THE DIVISION OF THERAPEUTICS AND 192 00:10:11,257 --> 00:10:15,294 MEDICAL CONSEQUENCES, THE MAIN 193 00:10:15,294 --> 00:10:18,398 DIVISION AT NIDA, THAT HELPS 194 00:10:18,398 --> 00:10:20,233 ACCELERATE DEVELOPMENT OF 195 00:10:20,233 --> 00:10:22,101 THERAPEUTICS. 196 00:10:22,101 --> 00:10:32,578 AND AFTER DR. RASMUSSEN LEFT, 197 00:10:32,578 --> 00:10:35,314 AFTER A LENGTHY SEARCH, THE 198 00:10:35,314 --> 00:10:37,517 DECISION BASICALLY BECAME CLEAR 199 00:10:37,517 --> 00:10:39,252 THAT DR. MONTOYA WAS THE BEST 200 00:10:39,252 --> 00:10:40,920 PERSON TO LEAD THAT EFFORT. 201 00:10:40,920 --> 00:10:45,591 SO NOW HE HAS BEEN OFFICIALLY 202 00:10:45,591 --> 00:10:46,592 APPOINTED, I THINK I HAVEN'T 203 00:10:46,592 --> 00:10:50,630 SEEN HIM THIS MORNING BUT IF 204 00:10:50,630 --> 00:10:53,566 HE'S NOT THERE WE LOOK FOR HIS 205 00:10:53,566 --> 00:10:55,802 LEADERSHIP, WHICH HE HAS BEEN 206 00:10:55,802 --> 00:10:58,304 CARRYING IT ALL ALONG, I WELCOME 207 00:10:58,304 --> 00:10:58,504 AGAIN. 208 00:10:58,504 --> 00:11:01,374 I ALWAYS SAY IT IS AN INCREDIBLE 209 00:11:01,374 --> 00:11:02,341 OPPORTUNITY WE HAVE ABSOLUTELY 210 00:11:02,341 --> 00:11:05,578 FOR PARTNERSHIP BETWEEN BOTH OF 211 00:11:05,578 --> 00:11:06,112 OUR INSTITUTES, BECAUSE 212 00:11:06,112 --> 00:11:08,081 MEDICATIONS AS WE MOVE AND MOVE 213 00:11:08,081 --> 00:11:09,082 WE'RE MOVING TOWARDS MEDICATIONS 214 00:11:09,082 --> 00:11:12,351 THAT ARE NOT SPECIFIC FOR ONE 215 00:11:12,351 --> 00:11:14,320 DRUG BUT MEDICATIONS THAT TARGET 216 00:11:14,320 --> 00:11:14,587 ADDICTION. 217 00:11:14,587 --> 00:11:17,957 IT DOES NOT MAKE SENSE TO BECOME 218 00:11:17,957 --> 00:11:19,659 REDUNDANT SO OPPORTUNITIES TO 219 00:11:19,659 --> 00:11:21,994 MAXIMIZE INFRASTRUCTURE FOR BOTH 220 00:11:21,994 --> 00:11:26,399 OF OUR INSTITUTES AND VICE 221 00:11:26,399 --> 00:11:27,700 VERSA, THIS DIALOGUE IS CRUCIAL. 222 00:11:27,700 --> 00:11:29,435 I WANT TO GIVE AN UPDATE OF 223 00:11:29,435 --> 00:11:32,738 WHERE WE ARE IN TERMS OF THE 224 00:11:32,738 --> 00:11:34,841 CONSUMPTION OF SUBSTANCES AMONG 225 00:11:34,841 --> 00:11:35,508 TEENAGERS, HIGH SCHOOL STUDENTS, 226 00:11:35,508 --> 00:11:37,443 AND THE REASON WHY I DO THINK 227 00:11:37,443 --> 00:11:38,778 IT'S IMPORTANT IS WHILE ACTUALLY 228 00:11:38,778 --> 00:11:41,414 THIS IS THE STAGE IN LIFE WHERE 229 00:11:41,414 --> 00:11:42,281 TEENAGERS START TO EXPERIMENT 230 00:11:42,281 --> 00:11:44,283 WITH DRUGS AND WHERE CAN YOU 231 00:11:44,283 --> 00:11:45,351 START TO SEE INITIATION OF 232 00:11:45,351 --> 00:11:47,987 CAREERS THAT CAN THEN LEAD TO 233 00:11:47,987 --> 00:11:49,322 ESCALATION OF DRUG USE, 234 00:11:49,322 --> 00:11:52,158 ADDICTION, OR IN SOME INSTANCES, 235 00:11:52,158 --> 00:11:54,994 VERY SEVERE OUTCOMES FROM CON 236 00:11:54,994 --> 00:11:56,429 CONSUMPTION OF THOSE DRUGS. 237 00:11:56,429 --> 00:11:58,598 I'M NOT GOING INTO GREAT DETAIL 238 00:11:58,598 --> 00:12:00,800 BECAUSE THE STORY CAN BE SAID IN 239 00:12:00,800 --> 00:12:02,535 THIS VERY NICE SLIDE THAT SHOWS 240 00:12:02,535 --> 00:12:03,970 ACTUALLY NOT THAT IT'S A NICE 241 00:12:03,970 --> 00:12:06,906 SLIDE BUT THE RESULTS ARE 242 00:12:06,906 --> 00:12:07,173 BEAUTIFUL. 243 00:12:07,173 --> 00:12:10,276 EVERYTHING IS GREEN, THAT MEANS 244 00:12:10,276 --> 00:12:12,378 GOING IN A GOOD DIRECTION. 245 00:12:12,378 --> 00:12:14,247 SIGNIFICANT REDUCTION IN THE 246 00:12:14,247 --> 00:12:15,648 CONSUMPTION OF SUBSTANCES FROM 247 00:12:15,648 --> 00:12:16,649 THE YEAR PRIOR. 248 00:12:16,649 --> 00:12:21,787 AND YOU CAN SEE IT FOR 8th, 249 00:12:21,787 --> 00:12:23,756 10th, 12 GRADERS, IN 250 00:12:23,756 --> 00:12:25,958 PARTICULAR CHANGES IN 12th 251 00:12:25,958 --> 00:12:26,526 GRADERS ARE RELEVANT BECAUSE 252 00:12:26,526 --> 00:12:29,595 THEY HAVE THE HIGHEST RATES OF 253 00:12:29,595 --> 00:12:31,097 DRUG CONSUMPTION. 254 00:12:31,097 --> 00:12:31,764 8th GRADERS CONSUMPTION IS 255 00:12:31,764 --> 00:12:32,865 VERY LOW. 256 00:12:32,865 --> 00:12:34,834 IT'S STRIKING THAT YOU SEE THE 257 00:12:34,834 --> 00:12:36,235 REDUCTIONS IN DRUG USE ACROSS 258 00:12:36,235 --> 00:12:38,137 ALL CATEGORIES OF DRUGS IN 259 00:12:38,137 --> 00:12:39,839 12th GRADERS WHETHER IT IS 260 00:12:39,839 --> 00:12:40,940 LEGAL OR ILLEGAL. 261 00:12:40,940 --> 00:12:42,708 I HAVE PRESENTED THAT LAST YEAR 262 00:12:42,708 --> 00:12:44,644 THAT ALSO WE HAVE SEEN FOR THE 263 00:12:44,644 --> 00:12:48,581 PAST I WOULD SAY THREE OR FIVE 264 00:12:48,581 --> 00:12:50,116 YEARS SIGNIFICANT REDUCTIONS IN 265 00:12:50,116 --> 00:12:50,783 ALCOHOL CONSUMPTION AMONG 266 00:12:50,783 --> 00:12:52,485 TEENAGERS THAT YOU CAN SEE IT 267 00:12:52,485 --> 00:12:54,754 NOT JUST IN TERMS OF INITIATION 268 00:12:54,754 --> 00:12:56,122 OF ALCOHOL DRINKING BUT 269 00:12:56,122 --> 00:12:59,559 IMPORTANTLY IN THE PATTERNS OF 270 00:12:59,559 --> 00:13:01,227 HARMFUL ALCOHOL CONSUMPTION. 271 00:13:01,227 --> 00:13:03,963 ALSO NOTABLE IS WE'RE NOT SEEING 272 00:13:03,963 --> 00:13:05,798 THE RISE IN CONSUMPTION OF 273 00:13:05,798 --> 00:13:07,900 CANNABIS THAT WE SEE IN ADULTS 274 00:13:07,900 --> 00:13:11,804 ACROSS ALL OF THE UNITED STATES. 275 00:13:11,804 --> 00:13:13,272 FOR WHATEVER REASON, TEENAGERS 276 00:13:13,272 --> 00:13:14,740 APPEAR TO BE PROTECTED. 277 00:13:14,740 --> 00:13:17,577 NOW, WHY IS IT THAT I AM 278 00:13:17,577 --> 00:13:19,345 HIGHLIGHTING THIS AS A VERY 279 00:13:19,345 --> 00:13:20,112 IMPORTANT NEWS? 280 00:13:20,112 --> 00:13:22,548 IT IS IMPORTANT BECAUSE WHEN THE 281 00:13:22,548 --> 00:13:24,317 COVID PANDEMIC CAME AROUND WE 282 00:13:24,317 --> 00:13:26,719 SAW DRAMATIC REDUCTION IN DRUG 283 00:13:26,719 --> 00:13:28,554 CONSUMPTION AMONG TEENAGERS. 284 00:13:28,554 --> 00:13:33,593 FOR MANY OF THE DRUGS THAT WERE 285 00:13:33,593 --> 00:13:36,095 THE HIGHEST REDUCTIONS WE'VE 286 00:13:36,095 --> 00:13:39,165 SEEN IN PATTERNS. 287 00:13:39,165 --> 00:13:39,732 NATURAL EXPLANATION, LIKELY 288 00:13:39,732 --> 00:13:41,000 CORRECT BECAUSE DRUG USE IN 289 00:13:41,000 --> 00:13:42,368 TEENAGERS IS VERY MUCH SENSITIVE 290 00:13:42,368 --> 00:13:44,136 TO PEER PRESSURE. 291 00:13:44,136 --> 00:13:45,972 THE FACT THAT TEENAGERS WERE NOT 292 00:13:45,972 --> 00:13:48,708 HAD THE OPPORTUNITIES OF 293 00:13:48,708 --> 00:13:50,576 INTERACTING WITH ONE ANOTHER AS 294 00:13:50,576 --> 00:13:52,011 SCHOOL GOES DOWN AND ACTIVITIES 295 00:13:52,011 --> 00:13:54,247 WHERE THEY USED TO GATHER WERE 296 00:13:54,247 --> 00:13:55,548 NO LONGER PRESENT, WHERE THEY 297 00:13:55,548 --> 00:13:57,617 WERE STUDYING AT HOME, WHERE THE 298 00:13:57,617 --> 00:14:00,119 PARENTS WERE OBSERVING THEIR 299 00:14:00,119 --> 00:14:02,655 BEHAVIORS, WOULD MAKE IT MUCH 300 00:14:02,655 --> 00:14:04,523 HARDER TO INITIATE AND TAKE 301 00:14:04,523 --> 00:14:04,857 DRUGS. 302 00:14:04,857 --> 00:14:07,360 INDEED THAT'S LIKELY TO HAVE 303 00:14:07,360 --> 00:14:08,794 BEEN DRIVEN VERY IMPORTANT 304 00:14:08,794 --> 00:14:11,297 FACTOR DRIVING THE VERY 305 00:14:11,297 --> 00:14:12,598 SIGNIFICANT REDUCTION THAT WE'RE 306 00:14:12,598 --> 00:14:13,899 OBSERVING DURING THE COVID 307 00:14:13,899 --> 00:14:14,200 PANDEMIC. 308 00:14:14,200 --> 00:14:16,302 OUR FEAR WAS THAT WHEN THE 309 00:14:16,302 --> 00:14:23,542 SCHOOLS WILL OPEN UP, THEN THE 310 00:14:23,542 --> 00:14:24,310 RELATIVE PREVALENCE AMONG 311 00:14:24,310 --> 00:14:26,812 TEENAGERS WOULD GO TO PRE-COVID 312 00:14:26,812 --> 00:14:27,046 LEVELS. 313 00:14:27,046 --> 00:14:28,314 WE'VE BEEN MONITORING LAST YEAR 314 00:14:28,314 --> 00:14:30,216 AND THIS YEAR TO SEE THAT 315 00:14:30,216 --> 00:14:32,952 HAPPENS, IT HAS NOT HAPPENED, 316 00:14:32,952 --> 00:14:34,687 WHICH AGAIN IS WHY I THINK IT IS 317 00:14:34,687 --> 00:14:35,888 VERY GOOD NEWS. 318 00:14:35,888 --> 00:14:38,090 AND YOU CAN SEE TO THE RIGHT 319 00:14:38,090 --> 00:14:40,960 THAT INDEED I DO NOT KNOW IF YOU 320 00:14:40,960 --> 00:14:42,928 CAN SEE MY POINTER, YOU CANNOT 321 00:14:42,928 --> 00:14:46,966 SEE MY POINTER BUT MAYBE THIS 322 00:14:46,966 --> 00:14:47,300 THING WORKS. 323 00:14:47,300 --> 00:14:54,940 ANYWAY, SORRY, SORRY, YOU CAN 324 00:14:54,940 --> 00:14:57,677 SEE TWO SLIDES HERE, BASICALLY 325 00:14:57,677 --> 00:14:59,745 YOU CAN SEE HOW IT HAS STAYED 326 00:14:59,745 --> 00:15:01,414 DOWN, HAS NOT GONE UP. 327 00:15:01,414 --> 00:15:04,784 IN THE TOP PANEL IS PERCENT OF 328 00:15:04,784 --> 00:15:05,551 STUDENTS REPORTING ILLICIT DRUG 329 00:15:05,551 --> 00:15:08,120 USE IN THE PAST YEAR BY GREAT. 330 00:15:08,120 --> 00:15:15,194 LOWER ONE IS DAILY USE OF 331 00:15:15,194 --> 00:15:16,629 MARIJUANA BY GRADE. 332 00:15:16,629 --> 00:15:18,364 MARIJUANA CARRIES THE WEIGHT IN 333 00:15:18,364 --> 00:15:21,867 INDICATOR MEASURE OF ANY ILLICIT 334 00:15:21,867 --> 00:15:22,968 SUBSTANCE, MOST REFLECTS 335 00:15:22,968 --> 00:15:30,543 MARIJUANA, YOU CAN SEE 336 00:15:30,543 --> 00:15:32,645 REDUCTION, STATE STABLE DESPITE 337 00:15:32,645 --> 00:15:33,579 LEGALIZATION AND PROLIFERATION. 338 00:15:33,579 --> 00:15:34,313 THAT IS NOTABLE. 339 00:15:34,313 --> 00:15:36,449 WHAT ARE THE ISSUES THAT I DO 340 00:15:36,449 --> 00:15:42,254 THINK IT'S IMPORTANT WE LOOK 341 00:15:42,254 --> 00:15:44,657 INTO THE DATA, AS IT JUMPS AT MY 342 00:15:44,657 --> 00:15:46,425 BRAIN, IN THE TABLE TO YOUR 343 00:15:46,425 --> 00:15:47,593 LEFT. 344 00:15:47,593 --> 00:15:48,728 ALCOHOL CONTINUES TO BE THE 345 00:15:48,728 --> 00:15:50,262 NUMBER ONE DRUG USED BY 346 00:15:50,262 --> 00:15:53,466 TEENAGERS. 347 00:15:53,466 --> 00:15:55,968 AND THIS IS PREVALENCE PAST YEAR 348 00:15:55,968 --> 00:15:57,069 IN THE 12th GRADERS, IN THE 349 00:15:57,069 --> 00:15:58,804 PAST YEAR HAVE YOU USED ALCOHOL. 350 00:15:58,804 --> 00:16:00,339 YOU CAN SEE EVEN THOUGH IT HAS 351 00:16:00,339 --> 00:16:01,774 GONE DOWN THERE'S STILL A 352 00:16:01,774 --> 00:16:03,542 SIGNIFICANT NUMBER OF TEENAGERS 353 00:16:03,542 --> 00:16:04,844 THAT ARE CONSUMING ALCOHOL. 354 00:16:04,844 --> 00:16:06,379 BUT THEN THE OTHER POINT THAT I 355 00:16:06,379 --> 00:16:08,647 WANT TO MAKE YOU AWARE OF IS 356 00:16:08,647 --> 00:16:11,817 CONSISTENTLY WHEN THIS TABLE IS 357 00:16:11,817 --> 00:16:13,719 PRESENTED, IT'S ALCOHOL FOLLOWED 358 00:16:13,719 --> 00:16:14,887 BY MARIJUANA. 359 00:16:14,887 --> 00:16:19,925 NOW MARIJUANA HAS A COMPETITOR, 360 00:16:19,925 --> 00:16:21,026 VAPING, ANY. 361 00:16:21,026 --> 00:16:23,996 SECOND USE AFTER ALCOHOL AMONG 362 00:16:23,996 --> 00:16:25,831 12th GRADERS IS MARIJUANA AND 363 00:16:25,831 --> 00:16:26,932 ANY TYPE OF VAPING. 364 00:16:26,932 --> 00:16:29,001 AND THIS IS SOMETHING THAT WE 365 00:16:29,001 --> 00:16:32,037 HAVE SEEN EMERGE VERY, VERY 366 00:16:32,037 --> 00:16:35,241 RAPIDLY IN FROM 2017 ONWARD, 367 00:16:35,241 --> 00:16:37,009 TAKING EXTREMELY HIGH LEVELS 368 00:16:37,009 --> 00:16:38,310 FORTUNATELY HAVE GONE DOWN, 369 00:16:38,310 --> 00:16:41,814 STILL LEADING TO BEING THE 370 00:16:41,814 --> 00:16:42,915 SECOND, ALONG WITH MARIJUANA, 371 00:16:42,915 --> 00:16:50,790 MOST FREQUENTLY USED DRUG. 372 00:16:50,790 --> 00:16:52,458 FOR VAPING NICOTINE, IT'S THE 373 00:16:52,458 --> 00:16:58,998 MAIN ONE, THERE'S ALSO VAPING 374 00:16:58,998 --> 00:17:01,534 FOR MARIJUANA, A WAY AT 375 00:17:01,534 --> 00:17:03,602 DELIVERING NICOTINE AT HIGH 376 00:17:03,602 --> 00:17:04,036 CONTENT FAST. 377 00:17:04,036 --> 00:17:06,338 REPORTS SHOW VAPING NICOTINE 378 00:17:06,338 --> 00:17:10,176 LEADS RAPIDLY TO ESCALATION INTO 379 00:17:10,176 --> 00:17:12,144 NICOTINE DEPENDENCE AND THEN 380 00:17:12,144 --> 00:17:13,345 INCREASING RISK FOR COMBUSTIBLE 381 00:17:13,345 --> 00:17:17,850 TOBACCO WITH ALL OF ITS NEGATIVE 382 00:17:17,850 --> 00:17:18,184 CONSEQUENCES. 383 00:17:18,184 --> 00:17:20,152 WHAT ELSE JUMPS INTO MY BRAIN IS 384 00:17:20,152 --> 00:17:23,989 WHERE I HAVE THE LITTLE STAR, 385 00:17:23,989 --> 00:17:26,158 HALLUCINOGENS, BECAUSE I HAVE 386 00:17:26,158 --> 00:17:28,661 BEEN IN NIDA SINCE 2003 AND HAVE 387 00:17:28,661 --> 00:17:29,929 NEVER SEEN HALLUCINOGENS MAKE IT 388 00:17:29,929 --> 00:17:33,065 TO THE TABLE AT THE TOP DRUGS 389 00:17:33,065 --> 00:17:35,367 TEENAGERS PICK UP AND THAT HAS 390 00:17:35,367 --> 00:17:35,801 CHANGED. 391 00:17:35,801 --> 00:17:39,505 IT'S AMONG THE TEN TOP DRUGS 392 00:17:39,505 --> 00:17:41,006 THAT TEENAGERS ARE USING, 12TH 393 00:17:41,006 --> 00:17:43,075 GRADER, SOMETHING WE NEED TO 394 00:17:43,075 --> 00:17:44,543 KEEP OUR EYE ON AND CERTAINLY 395 00:17:44,543 --> 00:17:45,911 ONE OF THE FACTORS IS 396 00:17:45,911 --> 00:17:47,713 HALLUCINOGENS HAVE BEEN IN THE 397 00:17:47,713 --> 00:17:50,583 MEDIA IN THE INTEREST AND 398 00:17:50,583 --> 00:17:51,450 BASICALLY THAT GENERATES 399 00:17:51,450 --> 00:17:51,817 CURIOSITY. 400 00:17:51,817 --> 00:17:54,653 TO THE RIGHT OF THAT TABLE YOU 401 00:17:54,653 --> 00:17:57,923 SEE IN RED ALL OF THE 402 00:17:57,923 --> 00:17:58,791 PSYCHOTHERAPEUTIC DRUGS, NOT 403 00:17:58,791 --> 00:18:01,093 THAT THEY PER SE ARE AT HIGH 404 00:18:01,093 --> 00:18:02,962 LEVELS, THEY ARE MUCH LOWER THAN 405 00:18:02,962 --> 00:18:07,466 WHERE THEY ARE, FOR EXAMPLE 406 00:18:07,466 --> 00:18:11,737 AMPHETAMINES 2.1%, NARCOTICS 407 00:18:11,737 --> 00:18:14,340 OTHER THAN HEROIN ARE VERY LOW 408 00:18:14,340 --> 00:18:17,643 REFLECTING OPIATE ANALGESICS. 409 00:18:17,643 --> 00:18:21,046 AT ONE POINT VICODIN WAS 9%, AT 410 00:18:21,046 --> 00:18:30,322 ONE POINT OXYCONTIN WAS 4.5 411 00:18:30,322 --> 00:18:35,361 DOWN, DOWN DRAMATICALLY. 412 00:18:35,361 --> 00:18:36,729 AMPHETAMINES AND TRANQUILIZER, 413 00:18:36,729 --> 00:18:39,965 ADDERALL, OPIATE ANALGESICS, ONE 414 00:18:39,965 --> 00:18:44,370 WAY FENTANYL IS GETTING INTO THE 415 00:18:44,370 --> 00:18:47,773 UNITED STATES IS DISGUISED AS 416 00:18:47,773 --> 00:18:50,242 ILLICITLY MANUFACTURED 417 00:18:50,242 --> 00:18:51,277 PRESCRIPTION PILLS, 418 00:18:51,277 --> 00:18:51,977 AMPHETAMINES, TRANQUILIZERS, 419 00:18:51,977 --> 00:18:52,578 OPIOID ANALGESICS. 420 00:18:52,578 --> 00:18:54,113 TO THE EXTENT THAT TEENAGERS GET 421 00:18:54,113 --> 00:18:57,616 THEIR HANDS ON THOSE PILLS THAT 422 00:18:57,616 --> 00:19:01,987 CAN LEAD WITH NO EXAGGERATION 423 00:19:01,987 --> 00:19:04,490 ONE SINGLE PILL CAN LEAD TO A 424 00:19:04,490 --> 00:19:05,391 STATE OF OVERDOSE, UNFORTUNATELY 425 00:19:05,391 --> 00:19:09,662 WE'VE SEEN THOSE GOING UP. 426 00:19:09,662 --> 00:19:11,397 HALLUCINOGENS, WHY IS IT THAT IT 427 00:19:11,397 --> 00:19:13,032 IS SORT OF ACTUALLY IN 428 00:19:13,032 --> 00:19:15,234 TEENAGERS, WHAT DOES IT TELL US 429 00:19:15,234 --> 00:19:15,868 IN ADULTS? 430 00:19:15,868 --> 00:19:18,070 IN GENERAL IT'S NOT LIKE THERE'S 431 00:19:18,070 --> 00:19:23,208 A PARALLEL WHAT HAPPENS IN 432 00:19:23,208 --> 00:19:24,043 ADOLESCENTS HAPPENS, MARIJUANA 433 00:19:24,043 --> 00:19:29,014 IS GOING UP IN ADULTS, NOT 434 00:19:29,014 --> 00:19:29,415 ADOLESCENTS. 435 00:19:29,415 --> 00:19:35,354 IN TERMS OF THE LANDSCAPE OF TWO 436 00:19:35,354 --> 00:19:37,222 PRODUCTS, NICOTINE VAPING AND 437 00:19:37,222 --> 00:19:38,457 HALLUCINOGENS, VAPING HIGHER 438 00:19:38,457 --> 00:19:39,858 AMONG TEENAGERS THAN ADULT 439 00:19:39,858 --> 00:19:41,927 POPULATION BUT WE'RE SEEING 440 00:19:41,927 --> 00:19:44,263 NICOTINE VAPING ACTUALLY ALSO 441 00:19:44,263 --> 00:19:45,497 RISING. 442 00:19:45,497 --> 00:19:48,167 NICOTINE VAPING AGAIN HAS THE 443 00:19:48,167 --> 00:19:50,803 SAME PROBLEMS THAT WAS REPORTING 444 00:19:50,803 --> 00:19:51,236 FOR ADOLESCENTS. 445 00:19:51,236 --> 00:19:55,207 I HAVE TWO FIGURES THAT ARE 446 00:19:55,207 --> 00:19:58,611 TAKEN FROM THE SAMHSA SURVEY. 447 00:19:58,611 --> 00:20:01,146 I'M POINTING YOU DIRECTING YOUR 448 00:20:01,146 --> 00:20:02,881 EYES TOWARDS WHAT CAUGHT MY 449 00:20:02,881 --> 00:20:03,549 ATTENTION. 450 00:20:03,549 --> 00:20:06,085 ALCOHOL NUMBER ONE AMONG ADULTS 451 00:20:06,085 --> 00:20:07,019 IN SUBSTANCES. 452 00:20:07,019 --> 00:20:11,657 THEN NUMBER TWO IN ADULTS 453 00:20:11,657 --> 00:20:15,127 TOBACCO PROVIDES. 454 00:20:15,127 --> 00:20:17,997 WE SEE MARIJUANA IS THIRD DRUG 455 00:20:17,997 --> 00:20:19,298 AMONG ADULTS. 456 00:20:19,298 --> 00:20:22,501 SO, HOW DOES IT -- THAT'S WHERE 457 00:20:22,501 --> 00:20:26,038 WE ARE RIGHT NOW, AND 458 00:20:26,038 --> 00:20:27,172 HALLUCINOGENS, 2.3 MILLION 459 00:20:27,172 --> 00:20:31,343 PEOPLE THAT SAID THEY HAVE USED 460 00:20:31,343 --> 00:20:33,012 HALLUCINOGENS IN THE PAST MONTH. 461 00:20:33,012 --> 00:20:36,281 TO THE RIGHT ARE THE NEW 462 00:20:36,281 --> 00:20:37,716 INITIATES EVERY YEAR, SOMETHING 463 00:20:37,716 --> 00:20:39,251 THAT NIDA REPORTS ALSO. 464 00:20:39,251 --> 00:20:42,321 WHAT CAUGHT MY EYE IS RELATIVE 465 00:20:42,321 --> 00:20:44,289 RATIO BETWEEN NEW INITIATES AND 466 00:20:44,289 --> 00:20:49,228 PREVALENCE IN THE PAST MONTH. 467 00:20:49,228 --> 00:20:50,195 AND IN PARTICULAR, HALLUCINOGENS 468 00:20:50,195 --> 00:20:53,365 CURRENTLY IN THE PAST MONTH 469 00:20:53,365 --> 00:20:54,700 2.3 MILLION AMERICANS TAKING 470 00:20:54,700 --> 00:20:58,437 HALLUCINOGENS, AND WE HAVE IN 471 00:20:58,437 --> 00:21:00,372 THE PAST YEAR 1.4 MILLION 472 00:21:00,372 --> 00:21:01,340 AMERICANS INITIATING 473 00:21:01,340 --> 00:21:01,874 HALLUCINOGENS. 474 00:21:01,874 --> 00:21:03,575 SO YOU SEE WHY THIS CAUGHT MY 475 00:21:03,575 --> 00:21:04,009 ATTENTION. 476 00:21:04,009 --> 00:21:08,047 THE NUMBER OF NEW INITIATES IS 477 00:21:08,047 --> 00:21:10,349 ALMOST EQUATING TO PATH MONTH OF 478 00:21:10,349 --> 00:21:11,750 USE WHICH BASICALLY IN MY BRAIN 479 00:21:11,750 --> 00:21:13,852 AT LEAST IS AN INDICATOR OF THE 480 00:21:13,852 --> 00:21:17,022 RATE OF RISE THAT WE'RE TO BE 481 00:21:17,022 --> 00:21:17,456 EXPECTING. 482 00:21:17,456 --> 00:21:19,725 SIMILARLY, THE OTHER ONE THAT 483 00:21:19,725 --> 00:21:22,361 ATTRACT MY ATTENTION NOT AS 484 00:21:22,361 --> 00:21:23,595 DRAMATICALLY BECAUSE HERE IT'S 485 00:21:23,595 --> 00:21:25,998 MORE THAN 50% NEW INITIATES OF 486 00:21:25,998 --> 00:21:29,635 THE TOTAL, AND THEN FOR VAPING 487 00:21:29,635 --> 00:21:30,936 APPROXIMATELY 25% OF NEW 488 00:21:30,936 --> 00:21:32,771 INITIATES FOR THE TOTAL. 489 00:21:32,771 --> 00:21:36,742 SO WE'RE GETTING -- IF YOU SEE 490 00:21:36,742 --> 00:21:40,379 RATIO VERSUS 23.5 YOU CAN SEE 491 00:21:40,379 --> 00:21:43,215 ALSO WHY IN MY BRAIN THIS 492 00:21:43,215 --> 00:21:45,818 INDICATES THAT THERE MAY BE 493 00:21:45,818 --> 00:21:48,353 POTENTIALLY AN INDICATION OF A 494 00:21:48,353 --> 00:21:49,788 RISE ON NICOTINE VAPING. 495 00:21:49,788 --> 00:21:51,857 NOW, SO THIS IS WHERE WE ARE 496 00:21:51,857 --> 00:21:53,459 WITH THE PANORAMA. 497 00:21:53,459 --> 00:21:57,329 IN TERMS OF RESEARCH PROGRAMS 498 00:21:57,329 --> 00:21:58,530 THAT ACTUALLY OBVIOUSLY ARE 499 00:21:58,530 --> 00:21:59,965 EQUIVALENT VALUE FOR BOTH OF OUR 500 00:21:59,965 --> 00:22:01,600 INSTITUTES AND FOR WHICH WE 501 00:22:01,600 --> 00:22:03,635 BASICALLY BOTH INSTITUTES HAVE 502 00:22:03,635 --> 00:22:06,205 BEEN WORKING SIDE BY SIDE 503 00:22:06,205 --> 00:22:07,973 CLOSELY AT ALL LEVELS, OF COURSE 504 00:22:07,973 --> 00:22:11,643 THE ABCD, WHICH HAS NOT BEEN 505 00:22:11,643 --> 00:22:12,244 POSSIBLE WITHOUT SUPPORT FROM 506 00:22:12,244 --> 00:22:14,113 THE NATIONAL INSTITUTE OF 507 00:22:14,113 --> 00:22:15,647 ALCOHOL ABUSE AND ALCOHOLISM, 508 00:22:15,647 --> 00:22:20,018 AND SORT OF CERTAINLY THE 509 00:22:20,018 --> 00:22:24,623 LEADSHIP OF DR. GEORGE KOOB, 510 00:22:24,623 --> 00:22:26,125 EIGHT YEARS AGO, THESE CHILDREN 511 00:22:26,125 --> 00:22:29,795 9 TO 10 ARE NOW GETTING AT 512 00:22:29,795 --> 00:22:31,864 ADOLESCENTS, AGE OF RISK FOR 513 00:22:31,864 --> 00:22:32,164 INITIATION. 514 00:22:32,164 --> 00:22:33,599 AND THAT DATA IS BECOMING 515 00:22:33,599 --> 00:22:33,932 AVAILABLE. 516 00:22:33,932 --> 00:22:40,105 I'M NOT GOING TO GO INTO IT 517 00:22:40,105 --> 00:22:42,174 BECAUSE YOU'LL HEAR FROM DR. 518 00:22:42,174 --> 00:22:45,677 GAYA DOWLING IN THE UPDATE FOR 519 00:22:45,677 --> 00:22:47,179 THIS EXTREMELY SUCCESSFUL STUDY 520 00:22:47,179 --> 00:22:48,514 AND FASCINATING STUDY. 521 00:22:48,514 --> 00:22:51,450 IT WAS SO SUCCESSFUL IT INSPIRED 522 00:22:51,450 --> 00:22:55,354 US TO SAY, WELL, WE MISSED 523 00:22:55,354 --> 00:22:57,222 INFANCY AND CHILDHOOD, SO 524 00:22:57,222 --> 00:23:00,859 INSPIRED BY ABC D WE STARTED THE 525 00:23:00,859 --> 00:23:04,029 HBCD, DISCUSSING IT FOUR YEARS 526 00:23:04,029 --> 00:23:08,734 AGO, AND WE STARTED SOME PILOTS 527 00:23:08,734 --> 00:23:12,271 2 1/2 YEARS AGO, OFFICIAL 528 00:23:12,271 --> 00:23:12,871 DELIVERRIVE GRANTS LAST YEAR, 529 00:23:12,871 --> 00:23:13,539 2023. 530 00:23:13,539 --> 00:23:17,943 AND THIS IS THE NETWORK. 531 00:23:17,943 --> 00:23:20,112 JUST CONCEIVED IN A SIMILAR WAY 532 00:23:20,112 --> 00:23:23,949 TO ABCD, INSTEAD OF RECRUITING 9 533 00:23:23,949 --> 00:23:26,151 TO 10 YEAR OLDS IT WILL RETHE 534 00:23:26,151 --> 00:23:29,421 VIEW INFANTS, THE OTHER ASPECT 535 00:23:29,421 --> 00:23:33,258 THAT MADE THIS MORE CHALLENGING 536 00:23:33,258 --> 00:23:35,661 WAS THE AIM TO RECRUIT 15% OF 537 00:23:35,661 --> 00:23:37,629 WOMEN EXPOSED TO OPIOIDS THAT 538 00:23:37,629 --> 00:23:39,164 NATURALLY ARE GOING TO ALSO VERY 539 00:23:39,164 --> 00:23:40,599 LIKELY AS WE WILL SEE JUST BY 540 00:23:40,599 --> 00:23:43,435 THE NATURE OF THE PREVALENCES BE 541 00:23:43,435 --> 00:23:46,171 EXPOSED TO A WIDE VARIETY OF 542 00:23:46,171 --> 00:23:47,573 OTHER SUBSTANCES INCLUDING 543 00:23:47,573 --> 00:23:48,373 ALCOHOL AND MARIJUANA. 544 00:23:48,373 --> 00:23:53,812 YOU ARE ALSO GOING TO BE HEARING 545 00:23:53,812 --> 00:24:02,688 AN UPDATE FROM DR. KATHLEEN 546 00:24:02,688 --> 00:24:02,888 COLE. 547 00:24:02,888 --> 00:24:04,857 LET ME JUMP TO THE REPORT OF 548 00:24:04,857 --> 00:24:05,757 OVERDOSE CRISIS. 549 00:24:05,757 --> 00:24:07,926 YESTERDAY I WAS SO HAPPY, 550 00:24:07,926 --> 00:24:09,461 DELIGHTED, LOOK, GUYS, IT'S THE 551 00:24:09,461 --> 00:24:13,966 FIRST TIME I PRESENT THIS TABLE 552 00:24:13,966 --> 00:24:15,167 WE SEE A REDUCTION. 553 00:24:15,167 --> 00:24:20,405 COLUMN TO THE LEFT, ALL DRUGS, 554 00:24:20,405 --> 00:24:24,576 IT'S IN GREEN, .49%, NOT A MAJOR 555 00:24:24,576 --> 00:24:29,715 NUMBER BUT IT'S NOT INCREASE, 556 00:24:29,715 --> 00:24:31,583 INCREASE, EVERY SINGLE MONTH 557 00:24:31,583 --> 00:24:33,852 THERE'S INCREASE, I WAS EXCITED. 558 00:24:33,852 --> 00:24:34,953 SOMEONE AT COUNCIL POINTED OUT 559 00:24:34,953 --> 00:24:36,388 THERE ARE MANY CHALLENGES BUT AT 560 00:24:36,388 --> 00:24:39,224 THE SAME TIME I TO NOT NEGATE 561 00:24:39,224 --> 00:24:43,929 THE PLEASURE OF SEEING A GREEN 562 00:24:43,929 --> 00:24:44,263 NUMBER. 563 00:24:44,263 --> 00:24:45,464 IT'S DRIVEN REDUCTION, WE 564 00:24:45,464 --> 00:24:48,200 CONTINUE TO SEE DRAMATIC 565 00:24:48,200 --> 00:24:51,703 REDUCTION IN DEATHS FROM HEROIN, 566 00:24:51,703 --> 00:24:52,604 SIGNIFICANT FROM OPIOID 567 00:24:52,604 --> 00:24:53,906 ANALGESICS, NO DEATHS REALLY 568 00:24:53,906 --> 00:24:56,408 THAT HAVE INCREASED FOR 569 00:24:56,408 --> 00:24:57,009 METHADONE. 570 00:24:57,009 --> 00:24:58,377 WE STILL SEE SIGNIFICANT 571 00:24:58,377 --> 00:25:00,579 INCREASES IN MORTALITY FROM 572 00:25:00,579 --> 00:25:02,881 FENTANYL, FROM COCAINE, 573 00:25:02,881 --> 00:25:03,248 METHAMPHETAMINE. 574 00:25:03,248 --> 00:25:04,283 COCAINE AND METHAMPHETAMINE 575 00:25:04,283 --> 00:25:06,151 MOSTLY ARE ASSOCIATED WITH 576 00:25:06,151 --> 00:25:07,886 COMBINATIONS OF THESE DRUGS, 577 00:25:07,886 --> 00:25:10,422 STIMULANTS, WITH FENTANYL. 578 00:25:10,422 --> 00:25:11,623 SO FENTANYL IS DRIVING REALLY 579 00:25:11,623 --> 00:25:13,158 MANY, MANY OF THE CHALLENGES 580 00:25:13,158 --> 00:25:14,693 THAT WE HAVE. 581 00:25:14,693 --> 00:25:17,095 SO, BECAUSE OF THIS, BECAUSE 582 00:25:17,095 --> 00:25:18,530 RECOGNITION ALSO THAT EVEN 583 00:25:18,530 --> 00:25:20,332 THOUGH IT STARTED WITH PAIN 584 00:25:20,332 --> 00:25:22,034 OPIOID OVERDOSE CRISIS AT THE 585 00:25:22,034 --> 00:25:24,303 BEGINNING, IT'S NOW FAR FROM 586 00:25:24,303 --> 00:25:24,536 THAT. 587 00:25:24,536 --> 00:25:27,639 AND, YES, THE MAIN CULPRIT IS 588 00:25:27,639 --> 00:25:27,906 FENTANYL. 589 00:25:27,906 --> 00:25:30,108 THERE'S NO TWO WAYS AROUND IT. 590 00:25:30,108 --> 00:25:31,977 BUT REALITY BEING SINCE THE 591 00:25:31,977 --> 00:25:37,015 MAJORITY OF THE CASES OF 592 00:25:37,015 --> 00:25:39,685 OVERDOSES CONTAIN MULTIPLE 593 00:25:39,685 --> 00:25:42,054 DRUGS, AND BASICALLY EXACERBATES 594 00:25:42,054 --> 00:25:44,289 DIFFICULTIES THAT CLINICIANS ARE 595 00:25:44,289 --> 00:25:46,491 HAVING, FIRST RESPONDERS IN 596 00:25:46,491 --> 00:25:49,761 REVERSING OVERDOSES ON ONE HAND 597 00:25:49,761 --> 00:25:50,562 BUT ALSO MAKING INCREASINGLY 598 00:25:50,562 --> 00:25:51,630 MORE COMPLEX TREATMENT OF PEOPLE 599 00:25:51,630 --> 00:25:55,033 THAT HAVE AN OPIOID USE 600 00:25:55,033 --> 00:25:56,568 DISORDER, BUT ALSO MAKING IT 601 00:25:56,568 --> 00:25:58,537 MORE URGENT TO PROVIDE FOR 602 00:25:58,537 --> 00:25:59,638 TREATMENT OF PEOPLE WITH 603 00:25:59,638 --> 00:26:00,405 STIMULANT USE DISORDER BECAUSE 604 00:26:00,405 --> 00:26:03,909 THE DRUGS THAT THEY BUY MAY BE 605 00:26:03,909 --> 00:26:04,910 CONTAMINATED WITH FENTANYL. 606 00:26:04,910 --> 00:26:07,312 WE MOVE REALLY TO TRY TO PUSH 607 00:26:07,312 --> 00:26:09,448 THE FIELD TO FOCUS ON 608 00:26:09,448 --> 00:26:11,350 INTERVENTIONS THAT WOULD BE 609 00:26:11,350 --> 00:26:13,018 BENEFICIAL ACROSS A WIDE VARIETY 610 00:26:13,018 --> 00:26:14,886 OF DRUGS. 611 00:26:14,886 --> 00:26:16,722 AND, AGAIN, THE FENCE OF 612 00:26:16,722 --> 00:26:18,156 ADDICTION WE KNOW AND SORT OF 613 00:26:18,156 --> 00:26:22,327 WHETHER IT IS FROM GENETICS THAT 614 00:26:22,327 --> 00:26:23,428 THE MOST SIGNIFICANT EXPLANATION 615 00:26:23,428 --> 00:26:25,530 OF GENES FOR THE VARIANTS IF YOU 616 00:26:25,530 --> 00:26:27,599 PUT ADDICTIONS OF ALL KIND IS 617 00:26:27,599 --> 00:26:28,900 FOR A GENERAL ADDICTION. 618 00:26:28,900 --> 00:26:30,902 IT DOESN'T MATTER THAT IT'S 619 00:26:30,902 --> 00:26:31,136 ALCOHOL. 620 00:26:31,136 --> 00:26:32,637 DOESN'T MATTER THAT IT'S 621 00:26:32,637 --> 00:26:35,040 CANNABIS OR OPIOIDS. 622 00:26:35,040 --> 00:26:36,675 IT'S A GENERAL ADDICTION FACTOR 623 00:26:36,675 --> 00:26:39,644 THAT ACCOUNTS FOR MOST OF THE 624 00:26:39,644 --> 00:26:42,047 VARIATION IN THAT POLYGENIC RISK 625 00:26:42,047 --> 00:26:42,347 SCORE. 626 00:26:42,347 --> 00:26:43,582 WHAT IT'S TELLING US WHAT DRUGS 627 00:26:43,582 --> 00:26:45,117 YOU MAY END UP TAKING VERY MUCH 628 00:26:45,117 --> 00:26:47,085 ARE LIKELY TO HAVE A BIG 629 00:26:47,085 --> 00:26:49,488 INFLUENCE WHAT YOU CAN 630 00:26:49,488 --> 00:26:49,821 ENCOUNTER. 631 00:26:49,821 --> 00:26:51,256 YES, THERE ARE SPECIFIC GENES 632 00:26:51,256 --> 00:26:53,425 THAT CAN DRIVE SPECIFIC 633 00:26:53,425 --> 00:26:55,394 CANNABIS, SPECIFIC ALCOHOL, 634 00:26:55,394 --> 00:26:56,395 SPECIFIC OPIOIDS, BUT THE 635 00:26:56,395 --> 00:27:00,532 RELATIVE WEIGHT OF THOSE GENES 636 00:27:00,532 --> 00:27:03,735 IS GENERAL ONE, MUCH MORE 637 00:27:03,735 --> 00:27:04,936 RESTRICTED. 638 00:27:04,936 --> 00:27:07,039 SIMILARLY WITH NEURAL IMAGING, 639 00:27:07,039 --> 00:27:08,340 ACTUALLY WE HAVE MANY OTHERS 640 00:27:08,340 --> 00:27:11,309 INCLUDING OUR LAB HAVE BEEN 641 00:27:11,309 --> 00:27:13,845 SHOWING THAT CONSISTENTLY REALLY 642 00:27:13,845 --> 00:27:15,580 THERE ARE ABSOLUTELY COMMON 643 00:27:15,580 --> 00:27:17,783 SEQUENCES DISRUPTED IN A SIMILAR 644 00:27:17,783 --> 00:27:19,484 WAY BETWEEN VARIOUS ADDICTIONS. 645 00:27:19,484 --> 00:27:22,354 WE, WE KNOW FROM BIOLOGY IT DOES 646 00:27:22,354 --> 00:27:25,323 MAKE SENSE TO TARGET COMMON 647 00:27:25,323 --> 00:27:26,792 INTERVENTIONS FOR VARIOUS 648 00:27:26,792 --> 00:27:27,225 SUBSTANCES. 649 00:27:27,225 --> 00:27:30,529 WHAT ARE THE SORT OF THINGS THAT 650 00:27:30,529 --> 00:27:32,397 HAVE ME VERY EXCITED BECAUSE OF 651 00:27:32,397 --> 00:27:33,698 NOVELTY, BECAUSE OF THE 652 00:27:33,698 --> 00:27:35,667 OPPORTUNITY THAT THEY CAN 653 00:27:35,667 --> 00:27:38,437 TRANSFORM TREATMENT IS OF COURSE 654 00:27:38,437 --> 00:27:38,804 NEUROMODULATION. 655 00:27:38,804 --> 00:27:40,639 YOU PROBABLY HAVE HEARD ABOUT IT 656 00:27:40,639 --> 00:27:42,941 A LOT, I'M NOT GOING INTO IT, 657 00:27:42,941 --> 00:27:45,811 JUST TO SAY THAT IT'S NOT JUST 658 00:27:45,811 --> 00:27:46,445 THAT WE'RE UNDERSTANDING ABOUT 659 00:27:46,445 --> 00:27:48,013 HOW AREAS OF THE BRAIN CONNECT 660 00:27:48,013 --> 00:27:50,849 WITH ONE ANOTHER AND HOW THEY 661 00:27:50,849 --> 00:27:52,584 ARE IMPLICATED IN DIFFERENT 662 00:27:52,584 --> 00:27:53,919 FUNCTIONAL PROCESSES, BUT THEN 663 00:27:53,919 --> 00:27:56,655 ALLOW US TO TAKE A TAILORED 664 00:27:56,655 --> 00:27:58,824 INTERVENTION TO THOSE, TO 665 00:27:58,824 --> 00:27:59,658 ADDRESS THE BEHAVIORAL 666 00:27:59,658 --> 00:28:01,593 DYSFUNCTIONS, BUT IT'S THE 667 00:28:01,593 --> 00:28:02,694 OPPORTUNITY TO ALSO ADVANCE 668 00:28:02,694 --> 00:28:04,963 TECHNOLOGY THAT CAN ALLOW US TO 669 00:28:04,963 --> 00:28:06,598 NEUROMODULATE THE BRAIN IN WAYS 670 00:28:06,598 --> 00:28:08,133 THAT ARE MUCH MORE PRECISE. 671 00:28:08,133 --> 00:28:10,669 AND THAT'S I THINK -- SO WE HAVE 672 00:28:10,669 --> 00:28:13,505 AT THE SAME TIME WE'RE GATHERING 673 00:28:13,505 --> 00:28:15,907 THE DATA IN LARGE DATABASES THAT 674 00:28:15,907 --> 00:28:18,009 CAN HELP US UNDERSTAND ALSO 675 00:28:18,009 --> 00:28:20,178 TRAJECTORY, SO THAT'S A 676 00:28:20,178 --> 00:28:20,779 FASCINATING AREA OF RESEARCH 677 00:28:20,779 --> 00:28:23,582 WHERE I THINK IT'S GOING TO BE 678 00:28:23,582 --> 00:28:25,584 REVOLUTIONIZING A LOT OF THE 679 00:28:25,584 --> 00:28:27,652 PSYCHIATRIC DISEASES, AND MAY IN 680 00:28:27,652 --> 00:28:29,521 FACT IN ONE DAY AND I THINK 681 00:28:29,521 --> 00:28:32,023 THAT'S WHY WE HAVE TO -- I THINK 682 00:28:32,023 --> 00:28:34,459 WE HAVE TO DARE TO IMAGINE, ONE 683 00:28:34,459 --> 00:28:40,298 SOMEDAY -- DAY WE IMAGINE USING 684 00:28:40,298 --> 00:28:43,635 IT FOR PREVENTION, CERTAIN 685 00:28:43,635 --> 00:28:45,337 CHARACTERISTICS THAT MADE YOU 686 00:28:45,337 --> 00:28:46,438 VULNERABLE TO IMPULSIVE ACTION 687 00:28:46,438 --> 00:28:48,406 COULD HELP MODULATE SO YOU DON'T 688 00:28:48,406 --> 00:28:51,076 ENCOUNTER RISK AND YOU MAXIMIZE 689 00:28:51,076 --> 00:28:52,043 POTENTIAL BENEFITS. 690 00:28:52,043 --> 00:28:55,847 ON THE MEDICATION, I MEAN, 691 00:28:55,847 --> 00:28:56,481 CERTAINLY PSYCHEDELICS GENERATED 692 00:28:56,481 --> 00:28:56,948 A LOT OF INTEREST. 693 00:28:56,948 --> 00:28:58,817 IN MY BRAIN I LOVE THEM BECAUSE 694 00:28:58,817 --> 00:29:01,753 IT OPENS UP THE WORLD OF THE 695 00:29:01,753 --> 00:29:05,157 OPPORTUNITY OF WORKING WITH 696 00:29:05,157 --> 00:29:05,757 NEUROPLASTICITY, ACCELERATING 697 00:29:05,757 --> 00:29:06,525 NEUROPLASTICITY AND LINKING IT 698 00:29:06,525 --> 00:29:09,060 WITH WHAT YOU WANT TO ACCELERATE 699 00:29:09,060 --> 00:29:13,031 SO IT'S SORT OF CHANGING THE WAY 700 00:29:13,031 --> 00:29:16,334 WE LOOK AT DRUGS. 701 00:29:16,334 --> 00:29:19,404 I'M FASCINATED LIKE MANY OTHERS 702 00:29:19,404 --> 00:29:21,940 BY GLP-1 RECEPTOR AGONIST, 703 00:29:21,940 --> 00:29:22,908 REPORTS IN ANECDOTAL REPORTS, 704 00:29:22,908 --> 00:29:24,376 STARTING TO CASE REPORTS IN 705 00:29:24,376 --> 00:29:30,015 LITERATURE SAYING PEOPLE THAT 706 00:29:30,015 --> 00:29:32,851 ARE ON OZEMPIC OR WAGOVY 707 00:29:32,851 --> 00:29:35,587 BASICALLY DON'T HAVE THE NEED TO 708 00:29:35,587 --> 00:29:36,788 ACTUALLY TAKE THESE DRUGS 709 00:29:36,788 --> 00:29:39,424 ANYMORE, AND THE DATA COMING OUT 710 00:29:39,424 --> 00:29:41,493 FROM ELECTRONIC RECORDS SHOWING 711 00:29:41,493 --> 00:29:45,564 PEOPLE THAT ARE GIVEN THESE 712 00:29:45,564 --> 00:29:47,532 MEDICATIONS FOR OBESITY OR 713 00:29:47,532 --> 00:29:48,967 DIABETES ARE IMPROVING ON 714 00:29:48,967 --> 00:29:50,035 SUBSTANCE USE DISORDER OUTCOMES. 715 00:29:50,035 --> 00:29:51,703 THERE ARE CLINICAL TRIALS BOTH 716 00:29:51,703 --> 00:29:56,741 IN THE ALCOHOL INSURE INSTITUTE 717 00:29:56,741 --> 00:29:58,944 AND OURS TO DO RANDOMIZED 718 00:29:58,944 --> 00:30:01,246 SELECTION TO DETERMINE ARE THERE 719 00:30:01,246 --> 00:30:02,113 EFFECTIVE OR NOT, WHAT 720 00:30:02,113 --> 00:30:04,616 CONDITIONS AND HOW TO USE THEM. 721 00:30:04,616 --> 00:30:06,484 BUT IT IS VERY EXCITING TO SEE 722 00:30:06,484 --> 00:30:08,687 THESE BECAUSE IF THEY DO WORK, 723 00:30:08,687 --> 00:30:10,555 IF THEY ARE RANDOMIZED CLINICAL 724 00:30:10,555 --> 00:30:11,790 TRIALS, DO WORK, THEN THIS CAN 725 00:30:11,790 --> 00:30:13,925 BE BROUGHT INTO THE CLINIC 726 00:30:13,925 --> 00:30:14,826 RELATIVELY FAST. 727 00:30:14,826 --> 00:30:16,428 BECAUSE IT'S A NEW INDICATION AS 728 00:30:16,428 --> 00:30:20,498 OPPOSED TO HAVING TO GO FROM 729 00:30:20,498 --> 00:30:20,765 BEGINNING. 730 00:30:20,765 --> 00:30:23,568 THE FINAL POINT I WANT TO MAKE, 731 00:30:23,568 --> 00:30:24,769 I WANTED TO ACTUALLY HIGHLIGHT 732 00:30:24,769 --> 00:30:26,871 IT BECAUSE I DO KNOW THAT 733 00:30:26,871 --> 00:30:29,074 NATIONAL INSTITUTE OF ALCOHOL 734 00:30:29,074 --> 00:30:30,475 ABUSE AND ALCOHOLISM HAS BEEN 735 00:30:30,475 --> 00:30:33,478 VERY MUCH INVOLVED IN SOME OF 736 00:30:33,478 --> 00:30:34,312 THE CHALLENGES THAT NATIVE 737 00:30:34,312 --> 00:30:37,249 AMERICANS HAVE IN TERMS OF 738 00:30:37,249 --> 00:30:37,916 ALCOHOLISM AND NEGATIVE 739 00:30:37,916 --> 00:30:40,752 CONSEQUENCES, TO THEM AND THEIR 740 00:30:40,752 --> 00:30:41,319 CHILDREN. 741 00:30:41,319 --> 00:30:44,389 AND THIS IS A SPACE THAT OVERALL 742 00:30:44,389 --> 00:30:46,424 AT THE NIH WE'VE NOT BEEN ABLE 743 00:30:46,424 --> 00:30:47,025 TO PENETRATE. 744 00:30:47,025 --> 00:30:49,160 IT'S A SPACE THAT IS VERY 745 00:30:49,160 --> 00:30:50,595 UNFORTUNATE BECAUSE IT IS 746 00:30:50,595 --> 00:30:51,263 HURTING THIS COMMUNITY. 747 00:30:51,263 --> 00:30:55,066 SO ALL OF THE ADVANCES THAT WE 748 00:30:55,066 --> 00:30:56,635 HAVE SCIENCE DON'T NECESSARILY 749 00:30:56,635 --> 00:30:57,602 RESULT IN BENEFITS FOR 750 00:30:57,602 --> 00:31:00,238 COMMUNITIES THAT ARE VERY, VERY 751 00:31:00,238 --> 00:31:01,740 AFFLICTED BY ACTUALLY TREMENDOUS 752 00:31:01,740 --> 00:31:02,874 HEALTH DISPARITIES. 753 00:31:02,874 --> 00:31:04,376 SO FOR THE OVERDOSE CRISIS LOOK 754 00:31:04,376 --> 00:31:05,744 AT THESE NUMBERS. 755 00:31:05,744 --> 00:31:07,579 THAT'S WHY I SORT OF SAID IN MY 756 00:31:07,579 --> 00:31:10,081 VIEW WHEN YOU HAVE NUMBERS LIKE 757 00:31:10,081 --> 00:31:11,716 THIS YOU CANNOT NOT DO SOMETHING 758 00:31:11,716 --> 00:31:13,051 THAT IS REALLY DIFFERENT FROM 759 00:31:13,051 --> 00:31:15,920 WHAT WE'VE BEEN DOING BEFORE. 760 00:31:15,920 --> 00:31:18,657 THE MORTALITY FROM OVERDOSES IS 761 00:31:18,657 --> 00:31:19,624 DOUBLE IN NATIVE AMERICANS TO 762 00:31:19,624 --> 00:31:20,825 THAT OF GENERAL POPULATION IN 763 00:31:20,825 --> 00:31:22,127 THE UNITED STATES. 764 00:31:22,127 --> 00:31:24,529 BLACK AMERICANS IT'S 50% HIGHER. 765 00:31:24,529 --> 00:31:26,431 SO, ONE OF OUR PRIORITIES THAT 766 00:31:26,431 --> 00:31:30,802 WE'RE LAUNCHING THIS YEAR IS 767 00:31:30,802 --> 00:31:32,304 BASICALLY THE NATIVE COLLECTIVE 768 00:31:32,304 --> 00:31:39,811 RESEARCH EFFORT TO ENHANCE 769 00:31:39,811 --> 00:31:42,514 WELLNESS, LED BY DR. KATHY EPPS 770 00:31:42,514 --> 00:31:44,482 IN PARTNERSHIP WITH ALL OF THE 771 00:31:44,482 --> 00:31:45,684 INSTITUTES THAT HAVE BEEN 772 00:31:45,684 --> 00:31:47,552 INVOLVED AS PART OF "HEAL" AND 773 00:31:47,552 --> 00:31:50,855 THE IDEA IS VERY BOLD APPROACH 774 00:31:50,855 --> 00:31:53,158 TO DO AN INVESTMENT ON TRIBES 775 00:31:53,158 --> 00:31:54,926 AND NATIVE AMERICANS SERVING 776 00:31:54,926 --> 00:31:56,227 ORGANIZATIONS TO ALLOW THEM TO 777 00:31:56,227 --> 00:31:57,929 BE ABLE TO DO RESEARCH, TO 778 00:31:57,929 --> 00:31:59,597 SELECT THE QUESTIONS THAT ARE 779 00:31:59,597 --> 00:32:02,467 RELEVANT TO THEM, TO ACTUALLY 780 00:32:02,467 --> 00:32:06,171 DEVELOP MODELS OF CARE THAT ARE 781 00:32:06,171 --> 00:32:07,372 AKIN TO THEIR CULTURE. 782 00:32:07,372 --> 00:32:10,775 THIS PROGRAM IS DIVIDED INTO 783 00:32:10,775 --> 00:32:13,078 PHASES, FIRST TWO YEARS 784 00:32:13,078 --> 00:32:14,612 APPROXIMATELY A TOTAL OF $25 785 00:32:14,612 --> 00:32:16,715 MILLION, AND THEN THE LAST PHASE 786 00:32:16,715 --> 00:32:18,883 2, IT WILL BE TO GIVE THE 787 00:32:18,883 --> 00:32:20,318 OPPORTUNITY TO -- FOR THE 788 00:32:20,318 --> 00:32:21,619 COMMUNITIES TO ORGANIZE 789 00:32:21,619 --> 00:32:23,488 THEMSELVES INTO A RESEARCH 790 00:32:23,488 --> 00:32:25,457 GROUPS GROUP DEPARTMENT, PARTNER 791 00:32:25,457 --> 00:32:26,424 BETWEEN THEM, OR WITH 792 00:32:26,424 --> 00:32:27,759 ORGANIZATIONS THAT CAN HELP 793 00:32:27,759 --> 00:32:29,160 PROVIDE THEM WITH SUPPORT IN 794 00:32:29,160 --> 00:32:39,337 ORDER TO BE ABLE TO BE PHASE 2 A 795 00:32:39,337 --> 00:32:40,338 $240 MILLION INVESTMENT TO 796 00:32:40,338 --> 00:32:43,174 EMPOWER NATIVE AMERICAN 797 00:32:43,174 --> 00:32:45,243 COMMUNITIES TO DO RESEARCH. 798 00:32:45,243 --> 00:32:46,978 AND THIS IS SORT OF SOMETHING 799 00:32:46,978 --> 00:32:53,585 THAT I COULD NOT NOT SHOW YOU, 800 00:32:53,585 --> 00:32:55,653 OH MY GOD, WHAT AM I SAYING? 801 00:32:55,653 --> 00:32:57,622 THIS IS OVERDOSE MORTALITY BY 802 00:32:57,622 --> 00:32:57,789 AGE. 803 00:32:57,789 --> 00:32:59,791 AND IT TELLS YOU THAT PEOPLE 804 00:32:59,791 --> 00:33:02,660 THAT ARE 35-44 YEARS OF AGE HAVE 805 00:33:02,660 --> 00:33:05,930 THE HIGHEST MORTALITY. 806 00:33:05,930 --> 00:33:07,465 SECOND HIGHEST MORTALITY 45-54, 807 00:33:07,465 --> 00:33:11,503 STARTS TO BECOME REALLY 808 00:33:11,503 --> 00:33:14,172 INTERESTING BECAUSE 45-54 IS NOT 809 00:33:14,172 --> 00:33:16,875 A DEMOGRAPHIC WITH HIGH LEVELS 810 00:33:16,875 --> 00:33:20,612 OF DRUG USE, 25-23, YES, BUT 811 00:33:20,612 --> 00:33:26,084 LOOK AT 55 TO 64, VERY HIGH 812 00:33:26,084 --> 00:33:29,888 LEVELS, HIGH LEVELS OF OVERDOSE 813 00:33:29,888 --> 00:33:31,523 MORTALITY. 814 00:33:31,523 --> 00:33:33,057 THEN COME DOWN, 65- 74 NOT AN 815 00:33:33,057 --> 00:33:34,058 AGE PEOPLE ARE NECESSARILY 816 00:33:34,058 --> 00:33:37,896 TAKING DRUGS THAT ARE GOING TO 817 00:33:37,896 --> 00:33:39,831 KILL THEM, ILLICIT SUBSTANCES. 818 00:33:39,831 --> 00:33:42,867 IN RED CIRCLES MORTALITY 819 00:33:42,867 --> 00:33:45,103 INCREASING FROM THE YEAR BEFORE. 820 00:33:45,103 --> 00:33:50,141 SO WE'RE SEEING, YES INCREASING 821 00:33:50,141 --> 00:33:52,544 MORTALITY BETWEEN 45-54, 55-64, 822 00:33:52,544 --> 00:33:54,946 65-74, AMONG THE OLDER 823 00:33:54,946 --> 00:33:55,246 POPULATION. 824 00:33:55,246 --> 00:33:58,316 AND EVEN THOUGH WE'RE STARTING 825 00:33:58,316 --> 00:34:01,753 TO SEE IN THE 15-24 IT'S COMING 826 00:34:01,753 --> 00:34:03,621 DOWN, 15-19 GOING UP. 827 00:34:03,621 --> 00:34:05,890 WE'RE SEEING OUR OVERDOSE 828 00:34:05,890 --> 00:34:09,060 MORTALITY IN GROUPS THAT DON'T 829 00:34:09,060 --> 00:34:12,997 SEEK HEROIN AND FENTANYL, ISSUE 830 00:34:12,997 --> 00:34:13,898 OF PSYCHOTHERAPEUTICS COMES TO 831 00:34:13,898 --> 00:34:14,499 PLAY HIGHLIGHTING IMPORTANCE 832 00:34:14,499 --> 00:34:17,302 WHAT IT IS OBVIOUS TO ALL OF US 833 00:34:17,302 --> 00:34:19,370 BUT NOT NECESSARILY ENDORSING TO 834 00:34:19,370 --> 00:34:23,074 THE NEXT LEVEL, IF WE TACKLE 835 00:34:23,074 --> 00:34:24,509 OVERDOSE CRISIS WE CANNOT JUST 836 00:34:24,509 --> 00:34:25,944 DEAL WITH TREATMENT FOR PEOPLE 837 00:34:25,944 --> 00:34:28,146 WITH OPIOID USE DISORDER OR 838 00:34:28,146 --> 00:34:32,584 OTHER SUBSTANCE USE DISORDER AND 839 00:34:32,584 --> 00:34:35,553 HELP THEM RECOVER, WE HAVE TO DO 840 00:34:35,553 --> 00:34:38,523 THAT BUT DEAL WITH PREVENTION, 841 00:34:38,523 --> 00:34:42,126 CASCADES TO ADDRESS THE CRISIS 842 00:34:42,126 --> 00:34:44,195 FROM PREVENTION, FROM PROVIDING 843 00:34:44,195 --> 00:34:45,396 HARM REDUCTION PRACTICES FOR 844 00:34:45,396 --> 00:34:46,498 THOSE ARE NOT READY FOR 845 00:34:46,498 --> 00:34:48,700 TREATMENT TO PROVIDE FOR 846 00:34:48,700 --> 00:34:50,435 TREATMENT, TO ACHIEVING 847 00:34:50,435 --> 00:34:53,304 RECOVERY, AND THAT WHOLE CASCADE 848 00:34:53,304 --> 00:34:54,906 IS AN AREA WE NEED TO INVEST 849 00:34:54,906 --> 00:34:56,441 FURTHER RESEARCH BECAUSE WE HAVE 850 00:34:56,441 --> 00:34:58,309 LIMITED RESEARCH ON HARM 851 00:34:58,309 --> 00:35:00,278 REDUCTION PRACTICES, LIMITED 852 00:35:00,278 --> 00:35:03,214 RESEARCH ALSO IN RECOVERY. 853 00:35:03,214 --> 00:35:07,118 AND WITH THAT I WANT TO 854 00:35:07,118 --> 00:35:08,486 ADVERTISE THAT NIDA IS TURNING 855 00:35:08,486 --> 00:35:12,090 50 THIS TUESDAY, AND ALL OUR 856 00:35:12,090 --> 00:35:14,726 WELCOME TO A CELEBRATION AT 857 00:35:14,726 --> 00:35:15,994 THE -- THAT WILL HAPPEN FROM 858 00:35:15,994 --> 00:35:21,933 FOUR TO SIX P.M. IN THE KENNEDY 859 00:35:21,933 --> 00:35:25,570 CAUCUS ROOM IN RUSSELL SENATE 860 00:35:25,570 --> 00:35:26,204 OFFICE BUILDING. 861 00:35:26,204 --> 00:35:28,706 THANK YOU FOR YOUR ATTENTION. 862 00:35:28,706 --> 00:35:37,215 >> SO, NORA, I THINK WE HAVE 863 00:35:37,215 --> 00:35:38,316 TIME FOR QUESTIONS. 864 00:35:38,316 --> 00:35:41,185 WE HAVE AT LEAST SIX MINUTES IF 865 00:35:41,185 --> 00:35:48,927 WE WANT TO STAY ON SCHEDULE. 866 00:35:48,927 --> 00:35:49,928 QUESTIONS FROM ANYONE? 867 00:35:49,928 --> 00:35:54,499 I ALWAYS HAVE QUESTIONS. 868 00:35:54,499 --> 00:35:56,234 WHAT ABOUT VAPING OF MARIJUANA, 869 00:35:56,234 --> 00:35:59,304 IS THAT ALSO INCREASING? 870 00:35:59,304 --> 00:36:01,072 I HEAR ANECDOTAL STORIES FROM 871 00:36:01,072 --> 00:36:05,376 PEOPLE BUT IS THERE ANY METRIC 872 00:36:05,376 --> 00:36:07,879 ON THAT WITH MONITORING? 873 00:36:07,879 --> 00:36:09,514 >> WE ALSO HAVE THE METRIC IN 874 00:36:09,514 --> 00:36:12,483 TEENAGERS, AND IT HAS GONE UP. 875 00:36:12,483 --> 00:36:14,652 WHAT HAD HAPPENED WAS VAPING 876 00:36:14,652 --> 00:36:15,887 OVERALL WHEN IT FIRST STARTED 877 00:36:15,887 --> 00:36:18,389 WENT TO EXTREMELY HIGH LEVELS, 878 00:36:18,389 --> 00:36:19,524 PREDOMINANTLY FAVORS. 879 00:36:19,524 --> 00:36:23,661 WE STARTED TO SEE IT COMING DOWN 880 00:36:23,661 --> 00:36:26,164 AND NICOTINE VAPING WENT UP, THC 881 00:36:26,164 --> 00:36:29,734 VAPING CONTINUES TO GO UP. 882 00:36:29,734 --> 00:36:30,668 STABILIZED SLOWLY. 883 00:36:30,668 --> 00:36:32,303 IF YOU LOOK AT THE TABLE IT'S 884 00:36:32,303 --> 00:36:33,938 AMONG THE TOP DRUGS. 885 00:36:33,938 --> 00:36:35,707 SO IT IS NICOTINE VAPING, AND 886 00:36:35,707 --> 00:36:38,343 THEN THE NEXT ONE WAS THC 887 00:36:38,343 --> 00:36:38,676 VAPING. 888 00:36:38,676 --> 00:36:41,279 SO IT IS AT HIGH LEVELS. 889 00:36:41,279 --> 00:36:43,815 AMONG PEOPLE IT IS ALSO IN 890 00:36:43,815 --> 00:36:45,116 ADULTS, I DON'T ACTUALLY RECALL 891 00:36:45,116 --> 00:36:46,784 THE NUMBER IN TERMS OF THE 892 00:36:46,784 --> 00:36:47,218 PREVALENCE RATES. 893 00:36:47,218 --> 00:36:48,753 BUT IT IS SOMETHING THAT WE NEED 894 00:36:48,753 --> 00:36:51,689 TO KEEP AN EYE ON BECAUSE THE 895 00:36:51,689 --> 00:36:55,827 PROBLEM IS YOU'RE DELIVERING 896 00:36:55,827 --> 00:36:59,263 EXTREMELY HIGH CONCENTRATIONS. 897 00:36:59,263 --> 00:37:01,332 >> HOW DO YOU ACCOUNT FOR THE 898 00:37:01,332 --> 00:37:04,168 LACK OF INCREASE IN CANNABIS USE 899 00:37:04,168 --> 00:37:08,406 GIVEN MANY STATES HAVE LEGALIZED 900 00:37:08,406 --> 00:37:10,742 RECREATIONAL USE OF CANNABIS AND 901 00:37:10,742 --> 00:37:13,044 MEDICAL USE OF CANNABIS ALSO 902 00:37:13,044 --> 00:37:16,180 AVAILABLE IN MANY STATES. 903 00:37:16,180 --> 00:37:18,483 >> YEAH, NO, CERTAINLY WE HAVE 904 00:37:18,483 --> 00:37:19,651 PREDICTED LEGALIZATION WOULD BE 905 00:37:19,651 --> 00:37:21,352 ASSOCIATED WITH HIGHER RISK OF 906 00:37:21,352 --> 00:37:21,653 CONSUMPTION. 907 00:37:21,653 --> 00:37:22,687 BUT WE HAVEN'T SEEN IT. 908 00:37:22,687 --> 00:37:23,988 I THINK THAT THE WAY THAT I 909 00:37:23,988 --> 00:37:25,957 EXPLAIN IT IS IN THE CONTEXT OF 910 00:37:25,957 --> 00:37:28,559 THE WHOLE LANDSCAPE OF DRUG USE 911 00:37:28,559 --> 00:37:29,560 PATTERNS AMONG TEENAGERS. 912 00:37:29,560 --> 00:37:32,096 ALL OF THEM HAVE BEEN GOING 913 00:37:32,096 --> 00:37:32,430 DOWN. 914 00:37:32,430 --> 00:37:33,731 NOT MARIJUANA USE WHICH IS 915 00:37:33,731 --> 00:37:34,098 STABLE. 916 00:37:34,098 --> 00:37:36,234 THERE'S SOMETHING THAT HAS 917 00:37:36,234 --> 00:37:39,637 CHANGED IN THE PATTERN OF HOW 918 00:37:39,637 --> 00:37:40,405 TEENAGERS ARE GETTING 919 00:37:40,405 --> 00:37:41,839 REINFORCERS THAT HAS LED THEM TO 920 00:37:41,839 --> 00:37:43,675 RELY LESS ON DRUGS THAT THEY DID 921 00:37:43,675 --> 00:37:45,977 IN THE PAST. 922 00:37:45,977 --> 00:37:48,813 CERTAINLY AT LEAST ON HIGH 923 00:37:48,813 --> 00:37:49,414 SCHOOL STUDENTS. 924 00:37:49,414 --> 00:37:50,782 AND THIS IS ALSO SURPRISING 925 00:37:50,782 --> 00:37:54,185 BECAUSE WHAT WE DO KNOW IS 926 00:37:54,185 --> 00:37:56,387 LEVELS OF ANXIETY, DEPRESSION 927 00:37:56,387 --> 00:37:57,922 INCREASED AMONG TEENAGERS AND 928 00:37:57,922 --> 00:37:58,589 SUICIDE. 929 00:37:58,589 --> 00:38:01,125 SO IT'S NOTABLE DESPITE THAT THE 930 00:38:01,125 --> 00:38:02,326 PATTERNS OF DRUG USE IN 931 00:38:02,326 --> 00:38:05,496 TEENAGERS APPEARS TO GO DOWN. 932 00:38:05,496 --> 00:38:07,031 SO IT IS ONE CAN SPECULATE AND 933 00:38:07,031 --> 00:38:08,700 FROM THE BEGINNING WHEN WE 934 00:38:08,700 --> 00:38:09,967 STARTED TO SEE, WAS JUST 935 00:38:09,967 --> 00:38:11,969 THINKING ABOUT IT IN TERMS OF 936 00:38:11,969 --> 00:38:13,071 OVERALL WHAT IS DRIVING 937 00:38:13,071 --> 00:38:14,138 REDUCTION IN DRUG USE AMONG 938 00:38:14,138 --> 00:38:14,605 TEENAGERS. 939 00:38:14,605 --> 00:38:18,009 ONE OF THE THINGS IN MY BRAIN AT 940 00:38:18,009 --> 00:38:21,045 THAT TIME WE'RE HAVING ALL OF 941 00:38:21,045 --> 00:38:22,046 THESE CELL PHONE-BASED 942 00:38:22,046 --> 00:38:22,947 TECHNOLOGIES THAT ALLOW 943 00:38:22,947 --> 00:38:24,782 TEENAGERS TO INTERACT WITH ONE 944 00:38:24,782 --> 00:38:26,284 ANOTHER, SOCIAL MEDIA. 945 00:38:26,284 --> 00:38:28,186 WITHOUT NECESSARILY HAVING TO BE 946 00:38:28,186 --> 00:38:31,456 WITH THE OTHER TEENAGERS. 947 00:38:31,456 --> 00:38:33,424 AND STILL HAVE SOCIAL NEEDS MET. 948 00:38:33,424 --> 00:38:35,960 BECAUSE OF THE PEER PRESSURE AND 949 00:38:35,960 --> 00:38:37,061 LIKELIHOOD OF PEOPLE BEING 950 00:38:37,061 --> 00:38:38,463 TOGETHER WHEN THEY START TO 951 00:38:38,463 --> 00:38:41,833 INITIATE DRUG USE, THAT MAY 952 00:38:41,833 --> 00:38:42,400 REDUCE IT. 953 00:38:42,400 --> 00:38:45,570 INTERESTINGLY, THAT LESS OF AN 954 00:38:45,570 --> 00:38:46,704 OPPORTUNITY FOR INTERACTION HAS 955 00:38:46,704 --> 00:38:48,639 BEEN ALSO SPECULATED TO ACCOUNT 956 00:38:48,639 --> 00:38:51,876 FOR SOME OF THE REASONS WHY YOU 957 00:38:51,876 --> 00:38:55,313 SEE AN INCREASE IN THE 958 00:38:55,313 --> 00:38:55,913 INTERNALIZING DISORDERS AMONG 959 00:38:55,913 --> 00:38:58,516 TEENAGERS, THEY DON'T HAVE THE 960 00:38:58,516 --> 00:38:59,717 OPPORTUNITY TO HAVE THE SOCIAL 961 00:38:59,717 --> 00:39:02,353 SUPPORTS THAT ARE NECESSARY FOR 962 00:39:02,353 --> 00:39:03,855 THEIR WELL-BEING. 963 00:39:03,855 --> 00:39:05,156 IT'S SPECULATIVE BUT THIS COULD 964 00:39:05,156 --> 00:39:08,126 BE ONE OF THE FACTOR. 965 00:39:08,126 --> 00:39:10,328 INCREASINGLY OBVIOUSLY VIDEO 966 00:39:10,328 --> 00:39:12,630 GAMING HAS BECOME A MAJOR 967 00:39:12,630 --> 00:39:13,164 REINFORCER FOR TEENAGERS, 968 00:39:13,164 --> 00:39:13,831 PARTICULARLY BOYS. 969 00:39:13,831 --> 00:39:16,667 IF YOU HAVE THESE ALTERNATIVE 970 00:39:16,667 --> 00:39:17,635 REINFORCERS AND YOU SEE 971 00:39:17,635 --> 00:39:26,144 TEENAGERS LIKE THIS, THAT GIVES 972 00:39:26,144 --> 00:39:27,378 YOU ENOUGH. 973 00:39:27,378 --> 00:39:28,813 SO ABCD, THE HBCD, POISED TO BE 974 00:39:28,813 --> 00:39:31,916 ABLE TO HELP US UNDERSTAND SOME 975 00:39:31,916 --> 00:39:33,417 OF THOSE DYNAMICS, BECAUSE AT 976 00:39:33,417 --> 00:39:35,620 THIS POINT IT'S JUST 977 00:39:35,620 --> 00:39:43,060 SPECULATIVE. 978 00:39:43,060 --> 00:39:49,967 979 00:39:49,967 --> 00:39:50,935 ANA. 980 00:39:50,935 --> 00:39:52,370 >> THANK YOU FOR THE INTERESTING 981 00:39:52,370 --> 00:39:52,703 INFORMATION. 982 00:39:52,703 --> 00:39:54,806 I WANTED TO ASK, YOU MENTIONED 983 00:39:54,806 --> 00:39:57,275 ABOUT THE DEPRESSION THAT IS 984 00:39:57,275 --> 00:39:58,609 GOING ON IN ADOLESCENTS. 985 00:39:58,609 --> 00:40:03,214 I WAS WOUND -- WONDERING IF 986 00:40:03,214 --> 00:40:05,283 HAVE YOU DATA CONNECTING VAPING 987 00:40:05,283 --> 00:40:06,918 AND NICOTINE IN PARTICULAR WITH 988 00:40:06,918 --> 00:40:10,955 DEPRESSION, IF IT'S USED AS A 989 00:40:10,955 --> 00:40:12,857 WAY OF AUTOMEDICATION, TO HANDLE 990 00:40:12,857 --> 00:40:16,227 DEPRESSION, IS THERE ANY 991 00:40:16,227 --> 00:40:17,962 INFORMATION ON THAT CONNECTION? 992 00:40:17,962 --> 00:40:19,931 >> YOU'RE ASKING ME -- IN MY 993 00:40:19,931 --> 00:40:21,499 BRAIN I DON'T HAVE SOMETHING 994 00:40:21,499 --> 00:40:23,668 CLEAR-CUT THAT I'VE SEEN OR PAID 995 00:40:23,668 --> 00:40:24,101 ATTENTION TO. 996 00:40:24,101 --> 00:40:25,636 BUT ONE CAN PREDICT IT'S THE 997 00:40:25,636 --> 00:40:30,241 CASE BECAUSE THAT IS ACTUALLY 998 00:40:30,241 --> 00:40:32,777 CERTAINLY MULTIPLE STUDIES SHOW 999 00:40:32,777 --> 00:40:33,311 FOR SMOKING CIGARETTES, 1000 00:40:33,311 --> 00:40:35,046 NICOTINE, OR MARIJUANA OR OTHER 1001 00:40:35,046 --> 00:40:36,480 DRUGS, ONE OF THE FACTORS THAT 1002 00:40:36,480 --> 00:40:38,115 MAKES TEENAGERS AT RISK FOR 1003 00:40:38,115 --> 00:40:40,518 USING SUBSTANCES IS WHAT YOU 1004 00:40:40,518 --> 00:40:41,419 SAY, AUTOMEDICATION. 1005 00:40:41,419 --> 00:40:42,820 I WOULD BE SURPRISED THAT THIS 1006 00:40:42,820 --> 00:40:44,856 WOULD NOT BE THE CASE FOR 1007 00:40:44,856 --> 00:40:46,324 NICOTINE VAPING SINCE THIS IS 1008 00:40:46,324 --> 00:40:48,192 ACTUALLY A STABLE ROUTE OF 1009 00:40:48,192 --> 00:40:49,160 ADMINISTRATION OF NICOTINE. 1010 00:40:49,160 --> 00:40:51,796 IF YOU LOOK AT THE PREVALENCE 1011 00:40:51,796 --> 00:40:54,298 FOR TOBACCO SMOKING AMONG 1012 00:40:54,298 --> 00:40:57,134 TEENAGERS IT'S EXTREMELY, 1013 00:40:57,134 --> 00:40:58,035 EXTREMELY LOW. 1014 00:40:58,035 --> 00:40:59,770 NOW NICOTINE VAPING IS TAKING 1015 00:40:59,770 --> 00:41:01,038 OVER. 1016 00:41:01,038 --> 00:41:04,141 AS YOU KNOW OBVIOUSLY NICOTINE 1017 00:41:04,141 --> 00:41:04,909 HAS ANTI-DEPRESSANT EFFECT AND 1018 00:41:04,909 --> 00:41:06,110 CAN MAKE YOU FEEL BETTER. 1019 00:41:06,110 --> 00:41:07,211 I SUSPECT THAT'S THE CASE. 1020 00:41:07,211 --> 00:41:13,351 ON THE TOP OF MY BRAIN I DON'T 1021 00:41:13,351 --> 00:41:14,118 HAVE IT. 1022 00:41:14,118 --> 00:41:16,754 AND NOW IT'S A PLEASURE TO 1023 00:41:16,754 --> 00:41:18,489 INTRODUCE DR. GEORGE KOOB, WHO 1024 00:41:18,489 --> 00:41:19,824 DOES NOT NEED AN INTRODUCTION 1025 00:41:19,824 --> 00:41:21,726 BUT I STILL WANT TO INTRODUCE 1026 00:41:21,726 --> 00:41:23,961 YOU. 1027 00:41:23,961 --> 00:41:30,001 1028 00:41:30,001 --> 00:41:40,044 1029 00:41:40,244 --> 00:41:41,812 >> IT'S A PLEASURE TO BE HERE. 1030 00:41:41,812 --> 00:41:42,980 THANK YOU, NORA. 1031 00:41:42,980 --> 00:41:45,850 I WAS REFLECTING ON THE FACT 1032 00:41:45,850 --> 00:41:49,453 THIS IS MY 11th CRAN MEETING. 1033 00:41:49,453 --> 00:41:51,522 AND I THINK YOU ALL KNOW THAT 1034 00:41:51,522 --> 00:41:53,057 NORA AND I HAVE COLLABORATED 1035 00:41:53,057 --> 00:41:55,559 TOGETHER FOR YEARS BUT I LOOKED 1036 00:41:55,559 --> 00:41:58,095 IT UP TODAY, WE'VE ACTUALLY 1037 00:41:58,095 --> 00:42:00,731 PUBLISHED SINCE OUR FIRST CRAN 1038 00:42:00,731 --> 00:42:02,033 MEETING 30 PAPERS TOGETHER IN 1039 00:42:02,033 --> 00:42:04,869 PEER-REVIEWED JOURNALS. 1040 00:42:04,869 --> 00:42:06,637 SO, IT'S PRETTY AMAZING HOW WELL 1041 00:42:06,637 --> 00:42:12,543 CRAN IS WORKING FROM A PERSONAL 1042 00:42:12,543 --> 00:42:13,978 VIEWPOINT. 1043 00:42:13,978 --> 00:42:19,116 SO YOU KNOW ME, I'M INTO THAT 1044 00:42:19,116 --> 00:42:19,884 KIND OF THING. 1045 00:42:19,884 --> 00:42:24,388 S BEEN A PLEASURE WORKING WITH 1046 00:42:24,388 --> 00:42:27,992 NORA PARTICULARLY AT THE LAB 1047 00:42:27,992 --> 00:42:29,760 LEVEL, HERS IN NIAAA AND MINE AT 1048 00:42:29,760 --> 00:42:39,070 NIGHT -- NIDA, AND WITH 1049 00:42:39,070 --> 00:42:42,573 LORENZO, WE WORK TOGETHER. 1050 00:42:42,573 --> 00:42:46,243 WE ALSO IN A SENSE THE VOLKOV 1051 00:42:46,243 --> 00:42:49,447 LAB IS PART OF THE METAVERSE, 1052 00:42:49,447 --> 00:42:50,314 THOUGHT YOU SHOULD KNOW THAT 1053 00:42:50,314 --> 00:42:52,717 PROBABLY ONE OF THE MOST 1054 00:42:52,717 --> 00:42:54,051 PLEASURABLE THINGS I DO AT NIH 1055 00:42:54,051 --> 00:42:56,120 IS WORKING WITH YOUNG PEOPLE, 1056 00:42:56,120 --> 00:42:58,889 AND I THINK THE SAME GOES FOR 1057 00:42:58,889 --> 00:42:59,090 NORA. 1058 00:42:59,090 --> 00:42:59,991 THE OTHER THING I WANTED TO 1059 00:42:59,991 --> 00:43:02,159 MENTION WE'VE HAD A VERY GOOD 1060 00:43:02,159 --> 00:43:03,361 RELATIONSHIP WITH NCI OVER THE 1061 00:43:03,361 --> 00:43:06,764 YEARS AND I'LL SHOW A PIECE OF 1062 00:43:06,764 --> 00:43:11,902 DATA ABOUT THAT IN A LITTLE BIT. 1063 00:43:11,902 --> 00:43:13,537 BUT OUR DIVISION OF EPIDEMIOLOGY 1064 00:43:13,537 --> 00:43:16,707 AND PREVENTION RESEARCH HAS BEEN 1065 00:43:16,707 --> 00:43:20,378 WORKING WITH DAVID BARRAGEN, 1066 00:43:20,378 --> 00:43:23,247 BILL WILL TELL YOU ABOUT SOME OF 1067 00:43:23,247 --> 00:43:25,216 THIS, BUT IT REALLY HAS BEEN A 1068 00:43:25,216 --> 00:43:26,550 PLEASURE WORKING WITH NCI AND 1069 00:43:26,550 --> 00:43:29,587 SOME OF THE DATA THAT ARE COMING 1070 00:43:29,587 --> 00:43:36,060 OUT ARE A LITTLE BIT STUNNING. 1071 00:43:36,060 --> 00:43:38,029 SO THIS THING ALWAYS DECIDES NOT 1072 00:43:38,029 --> 00:43:42,166 TO MOVE FOR THE FIRST SLIDE. 1073 00:43:42,166 --> 00:43:51,475 HOW DO I GET IT TO MOVE? 1074 00:43:51,475 --> 00:43:52,576 ANYBODY GOT AN IDEA? 1075 00:43:52,576 --> 00:43:55,513 IT HAS A MIND OF ITS OWN. 1076 00:43:55,513 --> 00:43:58,883 I HAD THIS HAPPEN YESTERDAY. 1077 00:43:58,883 --> 00:44:02,753 1078 00:44:02,753 --> 00:44:13,264 SORRY, IT ALWAYS STICKS ON THE 1079 00:44:44,829 --> 00:44:47,064 FIRST ONE. 1080 00:44:47,064 --> 00:44:47,465 THANKS. 1081 00:44:47,465 --> 00:44:48,699 NORA TALKED ABOUT STATISTICS. 1082 00:44:48,699 --> 00:44:50,868 I WANT TO REMIND YOU DURING THE 1083 00:44:50,868 --> 00:44:54,605 LAST 20 YEARS, IT'S REALLY BEEN 1084 00:44:54,605 --> 00:44:58,442 A DRAMATIC INCREASE IN ANNUAL 1085 00:44:58,442 --> 00:44:59,777 DEATHS FROM EXCESSIVE ALCOHOL. 1086 00:44:59,777 --> 00:45:03,647 DURING THE PANDEMIC WE SAW 25% 1087 00:45:03,647 --> 00:45:04,815 INCREASE IN ALCOHOL ACTUALLY 1088 00:45:04,815 --> 00:45:05,583 MENTIONED ON DEATH CERTIFICATES 1089 00:45:05,583 --> 00:45:06,817 IN THE FIRST YEAR OF THE 1090 00:45:06,817 --> 00:45:08,319 PANDEMIC AND IT WENT UP ANOTHER 1091 00:45:08,319 --> 00:45:10,387 10% IN THE SECOND YEAR OF THE 1092 00:45:10,387 --> 00:45:10,821 PANDEMIC. 1093 00:45:10,821 --> 00:45:11,655 AND DIDN'T COME DOWN IN THE 1094 00:45:11,655 --> 00:45:14,358 THIRD YEAR OF THE PANDEMIC. 1095 00:45:14,358 --> 00:45:16,760 AND THERE'S A TALE TO THESE KIND 1096 00:45:16,760 --> 00:45:18,762 OF THINGS IS MY POINT. 1097 00:45:18,762 --> 00:45:21,465 AND THE CDC NOW ESTIMATES THAT 1098 00:45:21,465 --> 00:45:22,900 IF YOU CONSIDER EVERYTHING FROM 1099 00:45:22,900 --> 00:45:26,504 FALLING OFF LADDERS AND RUNNING 1100 00:45:26,504 --> 00:45:33,310 YOUR MOTORCYCLE INTO A WALL WHEN 1101 00:45:33,310 --> 00:45:40,117 INTOXICATED WE LOSE 180,000 PER 1102 00:45:40,117 --> 00:45:44,588 YEAR DUE TO ALCOHOL. 1103 00:45:44,588 --> 00:45:46,223 RALPH KINGS STONN REMIND ME 1104 00:45:46,223 --> 00:45:52,863 ALCOHOL RELATED FATALITIES 1105 00:45:52,863 --> 00:45:53,564 INCREASED IN 2021. 1106 00:45:53,564 --> 00:45:55,299 WE HAD A NICE DISCUSSION AT OUR 1107 00:45:55,299 --> 00:45:56,734 COUNCIL MEETING YESTERDAY FOR 1108 00:45:56,734 --> 00:45:59,570 NIAAA, I WANT TO TALK ABOUT 1109 00:45:59,570 --> 00:46:00,804 WOMEN'S HEALTH, OLDER ADULTS, 1110 00:46:00,804 --> 00:46:02,239 AND WHOLE PERSON HEALTH. 1111 00:46:02,239 --> 00:46:03,941 ALL THIS DOVETAILS EXACTLY WHERE 1112 00:46:03,941 --> 00:46:06,143 THE THEMES NORA WAS TALKING 1113 00:46:06,143 --> 00:46:06,477 ABOUT. 1114 00:46:06,477 --> 00:46:09,980 LET'S COVER WOMEN'S HEALTH 1115 00:46:09,980 --> 00:46:10,214 QUICKLY. 1116 00:46:10,214 --> 00:46:12,249 THERE'S A NUMBER OF TRENDS GOING 1117 00:46:12,249 --> 00:46:15,786 ON THAT I WANT TO EMPHASIZE. 1118 00:46:15,786 --> 00:46:18,422 FOR ALL AGE GROUPS, DIFFERENCES 1119 00:46:18,422 --> 00:46:21,692 BETWEEN FEMALES AND MALES IN THE 1120 00:46:21,692 --> 00:46:22,927 PREVALENCE OF DRINKING AND BINGE 1121 00:46:22,927 --> 00:46:24,094 DRINKING IS NARROWING, GOING ON 1122 00:46:24,094 --> 00:46:24,862 FOR SOME TIME. 1123 00:46:24,862 --> 00:46:27,097 I THINK CAN YOU SEE THIS 1124 00:46:27,097 --> 00:46:28,732 ILLUSTRATED IN THE SLIDE. 1125 00:46:28,732 --> 00:46:31,769 THAT STAR IS NOT A STAR FOR 1126 00:46:31,769 --> 00:46:32,436 STATISTICALLY SIGNIFICANT. 1127 00:46:32,436 --> 00:46:34,438 IT'S A STAR THE MESSAGE CHANGED 1128 00:46:34,438 --> 00:46:35,039 IN 2020. 1129 00:46:35,039 --> 00:46:37,575 SO THE DATA MIGHT NOT BE EXACTLY 1130 00:46:37,575 --> 00:46:42,379 COMPARABLE BUT YOU CAN SEE A 1131 00:46:42,379 --> 00:46:43,147 STRAIGHT LINE DECREASE IN 1132 00:46:43,147 --> 00:46:44,682 UNDERAGE DRINKING, THIS IS GOOD 1133 00:46:44,682 --> 00:46:45,115 NEWS. 1134 00:46:45,115 --> 00:46:47,618 THERE'S A LITTLE BAD NEWS TO 1135 00:46:47,618 --> 00:46:50,387 THIS, YOU'LL NOTICE THERE'S BEEN 1136 00:46:50,387 --> 00:46:54,625 COMPLETE CROSSOVER, AND NOW 1137 00:46:54,625 --> 00:46:57,127 FEMALES ARE BINGE DRINKING AND 1138 00:46:57,127 --> 00:46:58,429 DRINKING IN GENERAL MORE THAN 1139 00:46:58,429 --> 00:47:00,097 MALES FOR THE FIRST TIME IN THIS 1140 00:47:00,097 --> 00:47:00,764 AGE GROUP. 1141 00:47:00,764 --> 00:47:04,368 AND IT'S BEEN GOING ON NOW FOR 1142 00:47:04,368 --> 00:47:04,668 THREE YEARS. 1143 00:47:04,668 --> 00:47:06,570 I'LL SO DATA IN A MINUTE THIS IS 1144 00:47:06,570 --> 00:47:09,406 NOT JUST IN THIS YOUNG AGE 1145 00:47:09,406 --> 00:47:09,840 GROUP. 1146 00:47:09,840 --> 00:47:11,475 PEOPLE UNDER 21 DRINKING LESS 1147 00:47:11,475 --> 00:47:13,677 BUT DECLINES ARE BIGGER FOR 1148 00:47:13,677 --> 00:47:14,545 MALES THAN FEMALES. 1149 00:47:14,545 --> 00:47:16,513 AS A RESULT, FEMALES IN THIS AGE 1150 00:47:16,513 --> 00:47:18,916 GROUP ARE MORE LIKELY THAN MALES 1151 00:47:18,916 --> 00:47:22,419 TO DRINK AND BINGE DRINK EACH 1152 00:47:22,419 --> 00:47:23,687 MONTH. 1153 00:47:23,687 --> 00:47:26,357 A SIMILAR PATTERN FOR PEOPLE 1154 00:47:26,357 --> 00:47:28,125 18-25, SO AGAIN CONSISTENT WITH 1155 00:47:28,125 --> 00:47:30,327 WHAT NORA SHOWED IN ONE OF HER 1156 00:47:30,327 --> 00:47:32,930 LAST SLIDES WE'RE SEEING A SHIFT 1157 00:47:32,930 --> 00:47:35,566 TO THE 25-35 YEAR OLD GROUP IN 1158 00:47:35,566 --> 00:47:36,467 PEAK ALCOHOL CONSUMPTION NOW IN 1159 00:47:36,467 --> 00:47:38,769 THE UNITED STATES. 1160 00:47:38,769 --> 00:47:41,605 IT'S NOT THE 18-25 YEAR OLD 1161 00:47:41,605 --> 00:47:41,972 GROUP. 1162 00:47:41,972 --> 00:47:43,140 IT'S 25-34 YEAR OLD GROUP. 1163 00:47:43,140 --> 00:47:45,542 AND THIS IS SOMETHING THAT I 1164 00:47:45,542 --> 00:47:48,212 THINK, YOU KNOW, PROBABLY ABCD 1165 00:47:48,212 --> 00:47:51,248 CAN ALSO HELP INFORM US. 1166 00:47:51,248 --> 00:47:53,651 AND THEN DOWN THE LINE. 1167 00:47:53,651 --> 00:47:55,219 AND FOR ADULTS 26 AND OLDER 1168 00:47:55,219 --> 00:47:56,553 ALCOHOL USE IS INCREASING FOR 1169 00:47:56,553 --> 00:48:00,791 WOMEN BUT NOT FOR MEN. 1170 00:48:00,791 --> 00:48:04,628 WHY IS THIS IMPORTANT TO NIAAA? 1171 00:48:04,628 --> 00:48:06,930 WELL, THERE'S WHAT WE CALL RISK 1172 00:48:06,930 --> 00:48:08,565 SEVERITY PARADOX FOR WOMEN. 1173 00:48:08,565 --> 00:48:10,668 WOMEN TEND TO EXPERIENCE A RANGE 1174 00:48:10,668 --> 00:48:13,037 OF ALCOHOL-RELATED HARMS AT 1175 00:48:13,037 --> 00:48:14,805 LOWER DOSES OF ALCOHOL OVER 1176 00:48:14,805 --> 00:48:17,007 SHORTER PERIODS OF TIME THAN 1177 00:48:17,007 --> 00:48:17,174 MEN. 1178 00:48:17,174 --> 00:48:19,643 STUDIESING IS WOMEN ARE MORE 1179 00:48:19,643 --> 00:48:21,712 LIKELY TO EXPERIENCE HANGOVERS, 1180 00:48:21,712 --> 00:48:26,317 BLACKOUTS, LIVER DISEASE, BRAIN 1181 00:48:26,317 --> 00:48:27,184 ATROPHY, COGNITIVE DEFICITS, 1182 00:48:27,184 --> 00:48:28,285 CARDIOMYOPATHY, CERTAIN CANCERS. 1183 00:48:28,285 --> 00:48:35,259 WOMEN ALSO HAVE FASTER 1184 00:48:35,259 --> 00:48:37,361 PROGRESSION OF ALCOHOL USE 1185 00:48:37,361 --> 00:48:37,928 DISORDER IN SEVERITY, 1186 00:48:37,928 --> 00:48:39,897 TELESCOPING EFFECT WITH ALCOHOL. 1187 00:48:39,897 --> 00:48:43,500 LESS LIKELY THAN MEN TO RECEIVE 1188 00:48:43,500 --> 00:48:46,470 TREATMENT FOR ALCOHOL USE 1189 00:48:46,470 --> 00:48:50,107 DISORDER. 1190 00:48:50,107 --> 00:48:55,212 LESS LIKELY IN SCREENING AND 1191 00:48:55,212 --> 00:48:59,383 REFERRAL, LESS LIKELY TO GET A 1192 00:48:59,383 --> 00:49:01,685 BRIEF INTERVENTION, DECREASES IN 1193 00:49:01,685 --> 00:49:02,653 HOSPITAL VISITS AND DEATHSING 1194 00:49:02,653 --> 00:49:04,621 FOR WOMEN COMPARING TO MEN, 1195 00:49:04,621 --> 00:49:07,458 ALCOHOL USE IN PREGNANCY STILL 1196 00:49:07,458 --> 00:49:11,295 PREVALENT, IN THE "HEAL" STUDY 1197 00:49:11,295 --> 00:49:12,696 AND HBCD STUDY, YOU KNOW, WE'RE 1198 00:49:12,696 --> 00:49:14,798 UNDOUBTEDLY GOING TO BE PICKING 1199 00:49:14,798 --> 00:49:19,503 UP ALCOHOL IN THAT CONTEXT. 1200 00:49:19,503 --> 00:49:22,906 SO 11% OF PEOPLE REPORT PAST 1201 00:49:22,906 --> 00:49:25,209 MONTH DRINKING, PREGNANT PEOPLE, 1202 00:49:25,209 --> 00:49:27,878 REPORT PAST MONTH DRINKING AND 1203 00:49:27,878 --> 00:49:30,147 5% REPORT BINGE DRINKING. 1204 00:49:30,147 --> 00:49:31,582 UNFORTUNATELY, THIS IS ON US, 1205 00:49:31,582 --> 00:49:32,883 BECAUSE WE REALLY NEED TO GET 1206 00:49:32,883 --> 00:49:35,052 THE WORD OUT, WE DISCUSSED THIS 1207 00:49:35,052 --> 00:49:38,055 A LOT AT COUNCIL YESTERDAY, MUCH 1208 00:49:38,055 --> 00:49:39,423 OF THE INITIAL DRINKING IS 1209 00:49:39,423 --> 00:49:41,291 BECAUSE PEOPLE DON'T KNOW THEY 1210 00:49:41,291 --> 00:49:42,192 ARE PREGNANT. 1211 00:49:42,192 --> 00:49:43,494 AND SO, YOU KNOW, OUR ADVICE 1212 00:49:43,494 --> 00:49:45,896 THESE DAYS IS DON'T DRINK WHEN 1213 00:49:45,896 --> 00:49:47,331 YOU'RE PREGNANT, DON'T DRINK 1214 00:49:47,331 --> 00:49:48,465 WHEN YOU'RE THINKING ABOUT 1215 00:49:48,465 --> 00:49:49,166 GETTING PREGNANT. 1216 00:49:49,166 --> 00:49:52,169 AND WOMEN ARE TWICE AS LIKELY TO 1217 00:49:52,169 --> 00:49:53,704 DEVELOP ANXIETY DISORDERS, PTSD, 1218 00:49:53,704 --> 00:49:55,038 AND DEPRESSION WHICH CAN 1219 00:49:55,038 --> 00:49:56,240 MOTIVATE DRINKING TO COPE. 1220 00:49:56,240 --> 00:50:01,145 ON THAT LINE I WOULD LIKE TO 1221 00:50:01,145 --> 00:50:02,146 OFFER A SECOND POSSIBILITY, 1222 00:50:02,146 --> 00:50:05,182 NORA, THAT'S GOING TO HAPPEN. 1223 00:50:05,182 --> 00:50:08,685 AND CONTRIBUTE TO THIS SHIFT TO 1224 00:50:08,685 --> 00:50:14,158 OLDER AGE GROUPS, AND THAT IS 1225 00:50:14,158 --> 00:50:18,896 THAT SOME OF THESE, YOU KNOW, 1226 00:50:18,896 --> 00:50:20,197 ANXIETY AND MENTAL ILLNESS ON 1227 00:50:20,197 --> 00:50:25,135 THE PTSD AND DEPRESSION MAY TEND 1228 00:50:25,135 --> 00:50:27,404 LATER, WE MAY SEE NEGATIVE 1229 00:50:27,404 --> 00:50:29,840 REINFORCEMENT PIECE KICK IN AS 1230 00:50:29,840 --> 00:50:32,609 PEOPLE AGE. 1231 00:50:32,609 --> 00:50:37,614 AND KIND OF REVERSE BENEFITS WE 1232 00:50:37,614 --> 00:50:37,781 SEE. 1233 00:50:37,781 --> 00:50:38,849 I AGREE WITH NORA, THERE'S BEEN 1234 00:50:38,849 --> 00:50:43,620 A MOVEMENT IN ALCOHOL FIELD AND 1235 00:50:43,620 --> 00:50:47,057 WE CALL IT SOBER CURIOUS, AND 1236 00:50:47,057 --> 00:50:50,561 THEN THE CHALLENGE ONES, WHICH 1237 00:50:50,561 --> 00:50:53,497 ARE DRY JANUARY, DRY OCTOBER, 1238 00:50:53,497 --> 00:50:55,032 THESE ARE VERY POPULAR WITH 1239 00:50:55,032 --> 00:50:56,266 YOUNG PEOPLE. 1240 00:50:56,266 --> 00:50:59,503 IT'S ALL FOCUSED AROUND A 1241 00:50:59,503 --> 00:51:00,237 HEALTHIER LIFESTYLE. 1242 00:51:00,237 --> 00:51:07,077 I REALLY LIKE ONE OF THE 1243 00:51:07,077 --> 00:51:10,280 STATEMENTS IN THE SLIDE 1244 00:51:10,280 --> 00:51:14,952 YESTERDAY ABOUT THAT WE'RE 1245 00:51:14,952 --> 00:51:18,222 DESTIGMATIZING, YOU KNOW, THE 1246 00:51:18,222 --> 00:51:23,927 HARMS OF ALCOHOL MISUSE BUT ALSO 1247 00:51:23,927 --> 00:51:25,696 DESTIGMATIZING THE ABILITY OF 1248 00:51:25,696 --> 00:51:27,331 PEOPLE TO OPT OUT AND NOT DRINK 1249 00:51:27,331 --> 00:51:28,866 AT ALL, SOMETHING I WANT TO 1250 00:51:28,866 --> 00:51:31,134 SENSITIZE YOU ALL TO. 1251 00:51:31,134 --> 00:51:33,537 MY COUNCIL IS ALREADY 1252 00:51:33,537 --> 00:51:33,837 SENSITIZED. 1253 00:51:33,837 --> 00:51:35,072 THERE SHOULD NEVER BE RECEPTION 1254 00:51:35,072 --> 00:51:39,710 AT A MEDICAL MEETING OR ANY 1255 00:51:39,710 --> 00:51:41,478 PARTY WHERE NON-ALCOHOL 1256 00:51:41,478 --> 00:51:44,314 CONTAINING BEVERAGES ARE NOT 1257 00:51:44,314 --> 00:51:45,282 PROVIDED. 1258 00:51:45,282 --> 00:51:46,283 MY KOOB DOUBLE NEGATIVE, MY 1259 00:51:46,283 --> 00:51:48,352 MOTHER'S NOT HAPPY WITH THAT. 1260 00:51:48,352 --> 00:51:49,453 ALL RIGHT. 1261 00:51:49,453 --> 00:51:52,189 SHE WAS AN ENGLISH PROFESSOR. 1262 00:51:52,189 --> 00:51:52,856 ALL RIGHT. 1263 00:51:52,856 --> 00:51:56,693 SO WHAT ARE SOME THINGS WE'RE 1264 00:51:56,693 --> 00:51:59,630 DOING ABOUT RESEARCH ON WOMEN'S 1265 00:51:59,630 --> 00:52:01,398 HEALTH LIKE OTHER NIH, ALL OTHER 1266 00:52:01,398 --> 00:52:04,468 NIH INSTITUTES AT THIS POINT, SO 1267 00:52:04,468 --> 00:52:07,771 WE'RE SUPPORTING STUDIES OF SEX 1268 00:52:07,771 --> 00:52:08,972 DIFFERENCES IN NEUROBIOLOGICAL 1269 00:52:08,972 --> 00:52:09,973 MECHANISMS, UNDERLYING ALCOHOL 1270 00:52:09,973 --> 00:52:12,476 MISUSE INCLUDING IMPACT OF 1271 00:52:12,476 --> 00:52:13,477 TRAUMA, LOOKING AT UNDERSTANDING 1272 00:52:13,477 --> 00:52:14,344 NEUROBIOLOGY OF NEGATIVE 1273 00:52:14,344 --> 00:52:15,779 REINFORCEMENT DRINKING AS I JUST 1274 00:52:15,779 --> 00:52:18,048 TALKED ABOUT, DRINKING TO COPE, 1275 00:52:18,048 --> 00:52:20,017 MORE COMMON IN WOMEN WITH 1276 00:52:20,017 --> 00:52:22,553 ALCOHOL IN PARTICULAR. 1277 00:52:22,553 --> 00:52:23,554 WE'RE TRACKING GENDER 1278 00:52:23,554 --> 00:52:25,489 DIFFERENCES AND NORMS ACROSS THE 1279 00:52:25,489 --> 00:52:26,590 LIFESPAN, DEVELOPING 1280 00:52:26,590 --> 00:52:27,958 INTERVENTIONS FOR PREGNANT AND 1281 00:52:27,958 --> 00:52:28,659 POSTPARTUM WOMEN. 1282 00:52:28,659 --> 00:52:32,162 SOME OF OUR NEW ACTIVITIES 1283 00:52:32,162 --> 00:52:34,031 INCLUDE RELEASING MODELS OF 1284 00:52:34,031 --> 00:52:35,299 CONTINUUMS OF CARE INITIATIVE, 1285 00:52:35,299 --> 00:52:36,099 EMPHASIZING AREAS OF RESEARCH 1286 00:52:36,099 --> 00:52:38,201 FOR THE WHITE HOUSE INITIATIVE 1287 00:52:38,201 --> 00:52:40,704 ON WOMEN'S HEALTH RESEARCH. 1288 00:52:40,704 --> 00:52:42,873 WE JUST -- THIS JUST CAME OUT, 1289 00:52:42,873 --> 00:52:46,743 AN RFA ON THE MODEL CONTINUUMS 1290 00:52:46,743 --> 00:52:49,346 OF CARE INITIATIVE, GOAL OF THE 1291 00:52:49,346 --> 00:52:52,783 MCCI TO REDUCE PREVALENCE AND 1292 00:52:52,783 --> 00:52:55,319 IMPACT OF MULTI-MORBIDITY AMONG 1293 00:52:55,319 --> 00:52:57,054 RACIAL/ETHNIC MINORITY WOMEN AND 1294 00:52:57,054 --> 00:53:02,092 GIRLS OF REPRODUCTIVE AGE AT 1295 00:53:02,092 --> 00:53:03,627 RISK OF LIVING WITH MENTAL 1296 00:53:03,627 --> 00:53:06,496 HEALTH DISORDERS, SUBSTANCE USE 1297 00:53:06,496 --> 00:53:07,798 DISORDERS, COMMON CO-OCCURRING 1298 00:53:07,798 --> 00:53:08,865 PHYSICAL CONDITIONS. 1299 00:53:08,865 --> 00:53:10,000 AND THIS DOVETAILS INTO 1300 00:53:10,000 --> 00:53:11,101 SOMETHING I'LL TALK ABOUT TOWARD 1301 00:53:11,101 --> 00:53:14,037 THE END ABOUT A WHOLE BODY 1302 00:53:14,037 --> 00:53:16,139 APPROACH TO PREVENTION AND 1303 00:53:16,139 --> 00:53:17,441 TREATMENT. 1304 00:53:17,441 --> 00:53:18,642 AND SO USING IMPLEMENTATION 1305 00:53:18,642 --> 00:53:20,077 DISSEMINATION SCIENCE THE 1306 00:53:20,077 --> 00:53:21,478 INITIATIVE PROPOSES CONTINUUM OF 1307 00:53:21,478 --> 00:53:23,347 CARE APPROACH THAT INTEGRATES 1308 00:53:23,347 --> 00:53:25,015 PREVENTIVE HEALTH SERVICES, 1309 00:53:25,015 --> 00:53:27,951 PRIMARY CARE, BEHAVIORAL HEALTH, 1310 00:53:27,951 --> 00:53:29,686 INTEGRATIVE CARE, AND 1311 00:53:29,686 --> 00:53:30,687 CARDIOPULMONARY AND ENDOCRINE 1312 00:53:30,687 --> 00:53:32,656 SPECIAL SIS TO FULLY ADDRESS 1313 00:53:32,656 --> 00:53:36,593 HEALTH CARE NEEDS IN THIS 1314 00:53:36,593 --> 00:53:37,694 VULNERABLE GROUP. 1315 00:53:37,694 --> 00:53:38,895 AND THEN IN COORDINATION WITH 1316 00:53:38,895 --> 00:53:41,164 WHITE HOUSE INITIATIVE ON 1317 00:53:41,164 --> 00:53:42,499 WOMEN'S HEALTH RESEARCH, NIH 1318 00:53:42,499 --> 00:53:45,235 ISSUED A NOSI TO HIGHLIGHT OUR 1319 00:53:45,235 --> 00:53:46,136 INTEREST IN APPLICATIONS FOCUSED 1320 00:53:46,136 --> 00:53:49,506 ON DISEASES AND HELD CONDITIONS 1321 00:53:49,506 --> 00:53:51,141 THAT AFFECT WOMEN PREDOMINANTLY, 1322 00:53:51,141 --> 00:53:52,876 THAT PRESENT AND PROGRESS 1323 00:53:52,876 --> 00:53:53,777 DIFFERENTLY IN WOMEN, OR THAT 1324 00:53:53,777 --> 00:53:56,279 ARE FEMALE SPECIFIC AND SOME OF 1325 00:53:56,279 --> 00:53:57,614 OUR SPECIFIC RESEARCH INTERESTS 1326 00:53:57,614 --> 00:53:58,815 THAT WE IDENTIFIED ARE RESEARCH 1327 00:53:58,815 --> 00:54:00,350 FOCUSED ON MENTAL HEALTH OF 1328 00:54:00,350 --> 00:54:02,219 WOMEN INCLUDING ALCOHOL AND 1329 00:54:02,219 --> 00:54:03,186 OTHER SUBSTANCE USE DISORDERS, 1330 00:54:03,186 --> 00:54:05,255 RESEARCH ON HEALTH ISSUES THAT 1331 00:54:05,255 --> 00:54:06,790 AFFECT YOUNG WOMEN INCLUDING 1332 00:54:06,790 --> 00:54:07,991 ETIOLOGY PREVENTION AND 1333 00:54:07,991 --> 00:54:10,293 TREATMENT OF ALCOHOL USE MISUSE, 1334 00:54:10,293 --> 00:54:11,495 RESEARCH TO UNDERSTAND 1335 00:54:11,495 --> 00:54:14,331 MECHANISMS THROUGH WHICH COMMON 1336 00:54:14,331 --> 00:54:15,232 ENVIRONMENTAL FACTORS INFLUENCE 1337 00:54:15,232 --> 00:54:17,334 RESILIENCE IN DISEASE AMONG 1338 00:54:17,334 --> 00:54:18,735 WOMEN ACROSS THE LIFESPAN. 1339 00:54:18,735 --> 00:54:20,037 WHAT ABOUT OLDER HEALTH? 1340 00:54:20,037 --> 00:54:22,639 NORA TOUCHED ON THIS AS WELL. 1341 00:54:22,639 --> 00:54:24,908 WELL, THE SIZE OF THE POPULATION 1342 00:54:24,908 --> 00:54:28,011 AGE 65 IS GROWING RAPIDLY. 1343 00:54:28,011 --> 00:54:32,149 IN BOTH PERCENT AND NUMBER OF 1344 00:54:32,149 --> 00:54:34,384 OLDER DRINKERS INCREASING. 1345 00:54:34,384 --> 00:54:36,687 AND YOU CAN SEE TWO PANELS HERE. 1346 00:54:36,687 --> 00:54:38,722 ON THE LEFT-HAND SIDE PERCENTAGE 1347 00:54:38,722 --> 00:54:42,025 OF PEOPLE 65 WHO DRANK ALCOHOL 1348 00:54:42,025 --> 00:54:45,295 IN THE PAST MONTH INCREASED 15% 1349 00:54:45,295 --> 00:54:47,597 OVERALL FROM 2002 TO 2022, 1350 00:54:47,597 --> 00:54:50,233 THAT'S 20 YEARS. 1351 00:54:50,233 --> 00:54:51,568 INCREASE IN WOMEN THAT'S 1352 00:54:51,568 --> 00:54:56,606 DRAMATIC BUT NOT FOR MEN, 1353 00:54:56,606 --> 00:54:57,908 CONVERGENCE AND ALMOST PARITY OF 1354 00:54:57,908 --> 00:54:59,009 WOMEN DRINKING WITH MEN. 1355 00:54:59,009 --> 00:55:04,147 I'VE ALREADY GIVEN YOU ALL THE 1356 00:55:04,147 --> 00:55:05,549 BACKGROUND TO THAT. 1357 00:55:05,549 --> 00:55:07,184 IF YOU LOOK AT THE PERCENT 1358 00:55:07,184 --> 00:55:10,921 INCREASE IN NUMBER OF DRINKERS, 1359 00:55:10,921 --> 00:55:12,456 THE SAME PATTERN EVOLVES, NOT 1360 00:55:12,456 --> 00:55:13,990 QUITE AS DRAMATIC BUT YOU SEE 1361 00:55:13,990 --> 00:55:17,160 DUE TO RAPID INCREASE IN SIZE OF 1362 00:55:17,160 --> 00:55:18,695 THE POPULATION 65+ THE NUMBER OF 1363 00:55:18,695 --> 00:55:23,066 PEOPLE TWO DRINK ALCOHOL 1364 00:55:23,066 --> 00:55:26,870 INCREASED 91% IN THE LAST 20 1365 00:55:26,870 --> 00:55:27,337 YEARS. 1366 00:55:27,337 --> 00:55:28,972 SO, YOU KNOW, THIS POPULATION IS 1367 00:55:28,972 --> 00:55:31,374 ONLY GOING TO GET LARGER AND 1368 00:55:31,374 --> 00:55:31,608 LARGER. 1369 00:55:31,608 --> 00:55:34,010 AND, YOU KNOW, WHY ARE WE 1370 00:55:34,010 --> 00:55:37,180 CONCERNED IN WELL, SAME ISSUES. 1371 00:55:37,180 --> 00:55:38,882 BUT MORE DRAMATIC AND DIFFERENT. 1372 00:55:38,882 --> 00:55:39,816 HEALTH CONSEQUENCES OF ALCOHOL 1373 00:55:39,816 --> 00:55:42,219 TEND TO SHIFT FROM ACUTE CAUSES, 1374 00:55:42,219 --> 00:55:44,154 INJURIES, TO CHRONIC CAUSES. 1375 00:55:44,154 --> 00:55:45,922 CANCER, HEART DISEASE, WITH AGE. 1376 00:55:45,922 --> 00:55:48,658 OLDER ADULTS ARE MORE SENSITIVE 1377 00:55:48,658 --> 00:55:49,526 TO THE SEDATIVE EFFECTS OF 1378 00:55:49,526 --> 00:55:50,727 ALCOHOL. 1379 00:55:50,727 --> 00:55:54,331 THIS IS A BIG ONE, THAT SOUNDS 1380 00:55:54,331 --> 00:55:56,099 TRIVIAL BUT VERY IMPORTANT, TAKE 1381 00:55:56,099 --> 00:55:57,601 MORE MEDICATIONS THAT MAY 1382 00:55:57,601 --> 00:55:58,602 INTERACT WITH ALCOHOL, MORE 1383 00:55:58,602 --> 00:56:00,137 LIKELY TO HAVE PROBLEMS WITH 1384 00:56:00,137 --> 00:56:04,941 SLEEP, WHICH IS WORSENED BY 1385 00:56:04,941 --> 00:56:05,275 ALCOHOL. 1386 00:56:05,275 --> 00:56:10,747 TWO PLUS TWO EQUALS FIVE WHEN IT 1387 00:56:10,747 --> 00:56:11,948 COMES TO RESPIRATORY DEPRESSION 1388 00:56:11,948 --> 00:56:14,251 AND ALCOHOL AND THOSE DRUG 1389 00:56:14,251 --> 00:56:14,484 CLASSES. 1390 00:56:14,484 --> 00:56:24,327 MOST SLEEP MEDICATIONS ARE SAID 1391 00:56:24,327 --> 00:56:26,530 SEDATIVE HYPNOTICS, ALCOHOL 1392 00:56:26,530 --> 00:56:29,232 MISUSE ASSOCIATED WITH FASTER 1393 00:56:29,232 --> 00:56:29,900 COGNITIVE DECLINE AND MAY WORSEN 1394 00:56:29,900 --> 00:56:32,002 ALZHEIMER'S DISEASE AND OTHER 1395 00:56:32,002 --> 00:56:33,737 FORMS OF DEMENTIA. 1396 00:56:33,737 --> 00:56:35,906 SO, WE'VE BEEN ALSO WORKING WITH 1397 00:56:35,906 --> 00:56:41,077 THE NATIONAL INSTITUTE ON AGING. 1398 00:56:41,077 --> 00:56:42,045 THANKS TO THEIR GENEROUS 1399 00:56:42,045 --> 00:56:43,046 SUPPLEMENT PROGRAM THAT WE'VE 1400 00:56:43,046 --> 00:56:45,782 NOW BEEN PART OF FOR QUITE A FEW 1401 00:56:45,782 --> 00:56:46,416 YEARS. 1402 00:56:46,416 --> 00:56:48,118 AND WE'RE WORKING ON LOOKING AT 1403 00:56:48,118 --> 00:56:50,487 ALCOHOL EFFECTS ON THE BRAIN 1404 00:56:50,487 --> 00:56:53,123 AGING PROCESSES AND HOW ALCOHOL 1405 00:56:53,123 --> 00:56:55,625 INFLUENCES DEMENTIAS AND 1406 00:56:55,625 --> 00:56:56,293 ALZHEIMER'S DISEASE. 1407 00:56:56,293 --> 00:56:58,495 IT'S STILL AN OPEN QUESTION 1408 00:56:58,495 --> 00:57:00,564 WHETHER ALCOHOL PROMOTES THE 1409 00:57:00,564 --> 00:57:03,466 DEVELOPMENT OF ALZHEIMER'S 1410 00:57:03,466 --> 00:57:05,602 DISEASE, EXACERBATES ALZHEIMER'S 1411 00:57:05,602 --> 00:57:06,670 DISEASE, PROBABLY, BUT WE STILL 1412 00:57:06,670 --> 00:57:09,206 REALLY NEED A LOT MORE WORK IN 1413 00:57:09,206 --> 00:57:10,507 THIS DOMAIN. 1414 00:57:10,507 --> 00:57:16,680 SO, WE'RE WORKING ON COGNITIVE 1415 00:57:16,680 --> 00:57:19,282 DECLINE, BEHAVIORAL 1416 00:57:19,282 --> 00:57:19,850 CONSEQUENCES, FUNCTIONAL 1417 00:57:19,850 --> 00:57:22,786 IMPAIRMENT INCLUDING HIV ANOTHER 1418 00:57:22,786 --> 00:57:29,159 ALLOSTATIC LOAD ON THE SYSTEM, 1419 00:57:29,159 --> 00:57:30,360 ALCOHOL CONTRIBUTES TO 1420 00:57:30,360 --> 00:57:31,695 INFLAMMATION AND ASSOCIATED 1421 00:57:31,695 --> 00:57:34,431 HARMS IN OLDER ADULTS. 1422 00:57:34,431 --> 00:57:36,299 ADDITIONAL PRIORITIES INCLUES 1423 00:57:36,299 --> 00:57:37,033 BASIC TRANSLATIONAND AND 1424 00:57:37,033 --> 00:57:38,568 CLINICAL RESEARCH ON THE EFFECT 1425 00:57:38,568 --> 00:57:42,072 ON THE HEALTH SPAN OF OLDER 1426 00:57:42,072 --> 00:57:42,606 ADULTS. 1427 00:57:42,606 --> 00:57:44,040 AGE-RELATED DISEASES, IMPROVING 1428 00:57:44,040 --> 00:57:45,242 ALCOHOL SCREENING, PREVENTION, 1429 00:57:45,242 --> 00:57:47,110 AND TREATMENT FOR OLDER ADULTS. 1430 00:57:47,110 --> 00:57:49,312 I WANT TO MENTION THAT MY 1431 00:57:49,312 --> 00:57:51,047 DEPUTY, TRISH POWELL, IS ALWAYS 1432 00:57:51,047 --> 00:57:54,751 REMINDING ME THAT ALL THESE 1433 00:57:54,751 --> 00:57:56,853 ADVERTISEMENTS ABOUT JOIN, YOU 1434 00:57:56,853 --> 00:57:58,054 KNOW, THIS RETIREMENT COMMUNITY, 1435 00:57:58,054 --> 00:57:59,656 WE HAVE HAPPY HOUR EVERY NIGHT. 1436 00:57:59,656 --> 00:58:00,891 IT'S ALL YOU CAN DRINK. 1437 00:58:00,891 --> 00:58:06,696 WALL -- ALL YOU WANT TO DRINK. 1438 00:58:06,696 --> 00:58:08,531 IT'S A CULTURE WE HAVE TO 1439 00:58:08,531 --> 00:58:11,101 COUNTER IN THIS DOMAIN AS WELL, 1440 00:58:11,101 --> 00:58:13,370 NOT JUST PHYSIOLOGICAL PARTS. 1441 00:58:13,370 --> 00:58:14,905 SO, WHOLE PERSON HEALTH, YOU 1442 00:58:14,905 --> 00:58:16,406 PROBABLY HAVE SEEN THIS SLIDE 1443 00:58:16,406 --> 00:58:19,175 BEFORE FROM US BUT ALCOHOL 1444 00:58:19,175 --> 00:58:20,143 MISUSE IS ASSOCIATED WITH MORE 1445 00:58:20,143 --> 00:58:25,849 THAN 200 DISEASES AND 1446 00:58:25,849 --> 00:58:27,450 INJURY-RELATED CONDITIONS. 1447 00:58:27,450 --> 00:58:29,019 DRINKING ALCOHOL ACTUALLY 1448 00:58:29,019 --> 00:58:30,887 INCREASES CANCER RISK, AND THERE 1449 00:58:30,887 --> 00:58:32,956 ARE VERY -- VERY FEW AMERICANS 1450 00:58:32,956 --> 00:58:36,660 ARE AWARE OF THIS LINK. 1451 00:58:36,660 --> 00:58:39,429 AND EVEN A LITTLE ALCOHOL CAN 1452 00:58:39,429 --> 00:58:40,864 HARM YOUR HEALTH. 1453 00:58:40,864 --> 00:58:44,267 WHEN I SHOW THIS SLIDE IN PUBLIC 1454 00:58:44,267 --> 00:58:46,136 LECTURES, THIS IS THE ONE THAT 1455 00:58:46,136 --> 00:58:48,738 GETS THE MOST ATTENTION. 1456 00:58:48,738 --> 00:58:49,372 ALCOHOL IS ACTUALLY A 1457 00:58:49,372 --> 00:58:50,907 CARCINOGEN. 1458 00:58:50,907 --> 00:58:54,311 IN THE U.S. 5.6% OF CANCER CASES 1459 00:58:54,311 --> 00:58:56,613 AND .4% OF DEATHS FROM CANCER 1460 00:58:56,613 --> 00:59:00,450 CAN BE ATTRIBUTED TO ALCOHOL -- 1461 00:59:00,450 --> 00:59:03,420 4% OF DEATHS FROM CANCER, 1462 00:59:03,420 --> 00:59:04,521 ALCOHOL IS THE THIRD LARGEST 1463 00:59:04,521 --> 00:59:06,256 CONTRIBUTOR TO ALL CANCER CASES 1464 00:59:06,256 --> 00:59:07,791 FOR WOMEN, FOURTH LARGEST FOR 1465 00:59:07,791 --> 00:59:08,792 MEN. 1466 00:59:08,792 --> 00:59:12,162 THE NUMBERS ARE IN THAT BULLET. 1467 00:59:12,162 --> 00:59:14,464 FOR WOMEN THE RISK OF BREAST 1468 00:59:14,464 --> 00:59:16,766 CANCER INCREASES 5 TO 15% WITH 1469 00:59:16,766 --> 00:59:18,201 EVEN A SINGLE STANDARD U.S. 1470 00:59:18,201 --> 00:59:22,572 SERVING OF ALCOHOL PER DAY. 1471 00:59:22,572 --> 00:59:24,641 THESE ARE EPIDEMIOLOGICAL 1472 00:59:24,641 --> 00:59:27,711 STUDIES, NOT CAUSAL, DIRECT 1473 00:59:27,711 --> 00:59:29,679 CAUSAL EVIDENCE, BUT IT'S 1474 00:59:29,679 --> 00:59:30,547 SOMETHING THAT PEOPLE SHOULD 1475 00:59:30,547 --> 00:59:31,314 KNOW ABOUT. 1476 00:59:31,314 --> 00:59:33,183 AND BREAST CANCER IS THE SECOND 1477 00:59:33,183 --> 00:59:35,819 LEADING CAUSE OF CANCER DEATH IN 1478 00:59:35,819 --> 00:59:38,121 WOMEN, ONLY LUNG CANCER KILLS 1479 00:59:38,121 --> 00:59:40,390 MORE WOMEN EACH YEAR. 1480 00:59:40,390 --> 00:59:41,257 AND UNFORTUNATELY AWARENESS OF 1481 00:59:41,257 --> 00:59:44,127 THE LINK BETWEEN ALCOHOL AND 1482 00:59:44,127 --> 00:59:47,397 CANCER IS LOW, SURVEY BY NCI 1483 00:59:47,397 --> 00:59:50,367 FOUND 70% OF PEOPLE ARE UNAWARE 1484 00:59:50,367 --> 00:59:52,769 ALCOHOL CAN CAUSE CANCER AND 10% 1485 00:59:52,769 --> 00:59:54,137 BELIEVE WINE REDUCES RISK OF 1486 00:59:54,137 --> 00:59:55,638 CANCER, A LOT OF PEOPLE THINK 1487 00:59:55,638 --> 00:59:58,108 WINE DOES EVERYTHING YOU WANT 1488 00:59:58,108 --> 00:59:58,575 FOR YOURSELF. 1489 00:59:58,575 --> 01:00:04,381 MOST OF THE DATA THAT WE'VE 1490 01:00:04,381 --> 01:00:05,048 ANALYZED, AARON WHITE HAS BEEN 1491 01:00:05,048 --> 01:00:07,517 DOING THIS FOR A NUMBER OF 1492 01:00:07,517 --> 01:00:09,586 YEARS, IT'S NOT THE WINE, IT'S 1493 01:00:09,586 --> 01:00:10,687 THE MEDITERRANEAN DIET. 1494 01:00:10,687 --> 01:00:14,124 IT'S NOT THE DRINK; IT'S THE 1495 01:00:14,124 --> 01:00:14,457 DRINKER. 1496 01:00:14,457 --> 01:00:15,291 ADDRESSING ALCOHOL IN THE 1497 01:00:15,291 --> 01:00:18,595 CONTEXT OF THE WHOLE PERSON 1498 01:00:18,595 --> 01:00:19,696 APPROACH, THAT LOOKS ACROSS 1499 01:00:19,696 --> 01:00:21,865 DIFFERENT DOMAINS OF HEALTH AND 1500 01:00:21,865 --> 01:00:23,066 INTEGRATES CARE OF 1501 01:00:23,066 --> 01:00:24,501 ALCOHOL-RELATED PROBLEMS CAN 1502 01:00:24,501 --> 01:00:27,203 IMPROVE PREVENTION DIAGNOSIS, 1503 01:00:27,203 --> 01:00:28,538 TREATMENT AND RECOVERY STRATEGY. 1504 01:00:28,538 --> 01:00:30,273 A COUPLE EXAMPLES. 1505 01:00:30,273 --> 01:00:30,840 INTEGRATING TREATMENT FOR 1506 01:00:30,840 --> 01:00:33,043 ALCOHOL USE DISORDER AND 1507 01:00:33,043 --> 01:00:34,444 ASSOCIATED DELIVER DISEASE HAS 1508 01:00:34,444 --> 01:00:36,079 POTENTIAL TO PROMOTE RECOVERY 1509 01:00:36,079 --> 01:00:38,148 FROM BOTH CONDITIONS AND ENHANCE 1510 01:00:38,148 --> 01:00:39,149 LONG-TERM SURVIVAL OF PATIENTS, 1511 01:00:39,149 --> 01:00:42,318 WE HAD A MEETING IN THIS ROOM A 1512 01:00:42,318 --> 01:00:43,753 COUPLE WEEKS AGO WITH THE LIVER 1513 01:00:43,753 --> 01:00:45,622 COMMUNITY AND IT WAS REALLY, 1514 01:00:45,622 --> 01:00:48,391 REALLY EYE OPENING AND 1515 01:00:48,391 --> 01:00:49,859 INFORMATIVE, AND THERE'S A GOOD 1516 01:00:49,859 --> 01:00:52,062 BIT OF INTEGRATION GOING ON NOW. 1517 01:00:52,062 --> 01:00:54,464 AND AT A MINIMUM YOU CAN THINK 1518 01:00:54,464 --> 01:00:57,634 OF LIVER DISEASE AS A VERY 1519 01:00:57,634 --> 01:00:59,602 POWERFUL BIOMARKER FOR A MAJOR 1520 01:00:59,602 --> 01:01:00,937 ALCOHOL PROBLEM. 1521 01:01:00,937 --> 01:01:01,805 ALCOHOL SCREENING, BRIEF 1522 01:01:01,805 --> 01:01:03,006 INTERVENTION, REFERRAL TO 1523 01:01:03,006 --> 01:01:04,307 TREATMENT IN PRIMARY CARE CAN 1524 01:01:04,307 --> 01:01:06,643 HELP IDENTIFY OTHER PHYSICAL AND 1525 01:01:06,643 --> 01:01:10,346 MENTAL HEALTH-RELATED ISSUES 1526 01:01:10,346 --> 01:01:12,515 AFFECTED BY ALCOHOL MISUSE 1527 01:01:12,515 --> 01:01:14,517 INCLUDING CO-USE OF OTHER DRUGS 1528 01:01:14,517 --> 01:01:15,385 OF ADDICTION. 1529 01:01:15,385 --> 01:01:17,787 I MIGHT POINT OUT THAT WE GET A 1530 01:01:17,787 --> 01:01:20,757 LOT OF SCREENING, 70% IN SOME 1531 01:01:20,757 --> 01:01:21,825 STUDIES, BUT BRIEF INTERVENTION 1532 01:01:21,825 --> 01:01:23,893 AND REVEAL TO TREATMENT IS 1533 01:01:23,893 --> 01:01:24,227 ABYSMAL. 1534 01:01:24,227 --> 01:01:27,831 I KNOW IT'S SIMILAR FOR OTHER 1535 01:01:27,831 --> 01:01:31,468 DRUGS OF ADDICTION. 1536 01:01:31,468 --> 01:01:33,369 AND OUR COLLABORATIVE RESEARCH 1537 01:01:33,369 --> 01:01:38,475 ACROSS WITH NIDA AND NCI AND 1538 01:01:38,475 --> 01:01:39,642 OTHERS HOLDS PROMISE FOR 1539 01:01:39,642 --> 01:01:41,845 UNDERSTANDING WHOLE BODY HEALTH, 1540 01:01:41,845 --> 01:01:45,014 WHOLE PERSON HEALTH, IMPROVING 1541 01:01:45,014 --> 01:01:47,484 SUBSTANCE MISUSE HEALTH-RELATED 1542 01:01:47,484 --> 01:01:49,385 CONSEQUENCES AND OUTCOMES. 1543 01:01:49,385 --> 01:01:52,455 I'M PROUD TO ANNOUNCE THAT WE 1544 01:01:52,455 --> 01:01:54,424 HAVE LAUNCHED OUR NEW STRATEGIC 1545 01:01:54,424 --> 01:01:57,360 PLAN AS OF THIS WEEK. 1546 01:01:57,360 --> 01:01:58,228 ADVANCING ALCOHOL RESEARCH TO 1547 01:01:58,228 --> 01:02:00,330 PROMOTE WHOLE PERSON HEALTH AND 1548 01:02:00,330 --> 01:02:00,630 WELL-BEING. 1549 01:02:00,630 --> 01:02:02,866 IT'S NOW LIVE ON OUR WEBSITE. 1550 01:02:02,866 --> 01:02:03,967 BY THE WAY, THERE'S A LOT OF 1551 01:02:03,967 --> 01:02:08,538 GREAT INFORMATION ON OUR 1552 01:02:08,538 --> 01:02:08,872 WEBSITE. 1553 01:02:08,872 --> 01:02:10,406 PLAN CHARTS A COURSE OVER THE 1554 01:02:10,406 --> 01:02:12,709 NEXT FIVE YEARS WHILE MAIN TAKES 1555 01:02:12,709 --> 01:02:14,010 FLEXIBILITY TO ADDRESS RESEARCH 1556 01:02:14,010 --> 01:02:14,878 OPPORTUNITIES AND URGENT PUBLIC 1557 01:02:14,878 --> 01:02:16,446 HEALTH NEEDS, THE PLAN IS A 1558 01:02:16,446 --> 01:02:19,149 LIVING DOCUMENT AND WE WELCOME 1559 01:02:19,149 --> 01:02:20,183 YOUR FEEDBACK. 1560 01:02:20,183 --> 01:02:24,521 THANK YOU TO ALL OF NIAAA STAFF 1561 01:02:24,521 --> 01:02:28,224 WHO CONTRIBUTED TO THE STRATEGIC 1562 01:02:28,224 --> 01:02:29,659 PLAN CONTENT INCLUDING COUNCIL 1563 01:02:29,659 --> 01:02:29,893 MEMBERS. 1564 01:02:29,893 --> 01:02:37,867 SPECIAL THANKS TO THE NIAAA 1565 01:02:37,867 --> 01:02:42,238 STRATEGIC PLAN TEAM, CARY, 1566 01:02:42,238 --> 01:02:52,615 LAURA, LAURA, BRIDGIT, AND 1567 01:02:52,615 --> 01:02:52,882 RACHEL. 1568 01:02:52,882 --> 01:02:55,618 BRIDGIT GAINED TEN YEARS TO HER 1569 01:02:55,618 --> 01:02:56,886 LIFE AFTER THIS WAS LAUNCHED, 1570 01:02:56,886 --> 01:02:58,188 YOU KNOW HOW CHALLENGING IT IS 1571 01:02:58,188 --> 01:02:59,522 TO PULL TOGETHER A STRATEGIC 1572 01:02:59,522 --> 01:02:59,756 PLAN. 1573 01:02:59,756 --> 01:03:02,025 SO THE TITLE IS THE FUTURE IS 1574 01:03:02,025 --> 01:03:02,492 NOW. 1575 01:03:02,492 --> 01:03:03,593 WHAT ARE WE FOCUSING ON? 1576 01:03:03,593 --> 01:03:07,096 THESE ARE COME OF THEM. 1577 01:03:07,096 --> 01:03:07,697 DIVERSITY, EQUITY, INCLUSION, 1578 01:03:07,697 --> 01:03:10,233 AND ACCESSIBILITY IN THE ALCOHOL 1579 01:03:10,233 --> 01:03:11,568 RESEARCH ENTERPRISE, WOMEN'S 1580 01:03:11,568 --> 01:03:13,436 HEALTH RESEARCH, AS I 1581 01:03:13,436 --> 01:03:15,171 ILLUSTRATED, WHOLE PERSON HEALTH 1582 01:03:15,171 --> 01:03:16,272 AND INTEGRATED HEALTH APPROACHES 1583 01:03:16,272 --> 01:03:18,508 AS I TALKED ABOUT, DATA SCIENCE, 1584 01:03:18,508 --> 01:03:21,010 ARTIFICIAL INTELLIGENCE, AND 1585 01:03:21,010 --> 01:03:23,279 DATA MANAGEMENT, TRANSLATION AND 1586 01:03:23,279 --> 01:03:25,515 BACK-TRANSLATION OF RESEARCH 1587 01:03:25,515 --> 01:03:27,250 FINDINGS, AND I EMPHASIZE BACK 1588 01:03:27,250 --> 01:03:28,117 TRANSLATION PART, HAPPY TO 1589 01:03:28,117 --> 01:03:29,352 DISCUSS THAT IF YOU'RE 1590 01:03:29,352 --> 01:03:29,652 INTERESTED. 1591 01:03:29,652 --> 01:03:30,954 SOCIAL DETERMINANTS OF HEALTH IN 1592 01:03:30,954 --> 01:03:33,590 THE CONTEXT OF RISK AND 1593 01:03:33,590 --> 01:03:34,357 RESILIENCE. 1594 01:03:34,357 --> 01:03:39,062 AND SOCIAL MEDIA IMPACT, NORA 1595 01:03:39,062 --> 01:03:43,733 WAS TALKING ABOUT THAT AND 1596 01:03:43,733 --> 01:03:48,238 SOCIAL MEDIA AS A TOOL FOR 1597 01:03:48,238 --> 01:03:48,938 INNOVATING INTERVENTIONS. 1598 01:03:48,938 --> 01:03:50,206 I'M GOING TO PREACH FOR ONE 1599 01:03:50,206 --> 01:03:52,609 MINUTE OR TWO BUT WE HAVE A LOT 1600 01:03:52,609 --> 01:03:54,244 OF RESOURCES OUT THERE THAT CAN 1601 01:03:54,244 --> 01:03:55,912 BE USED. 1602 01:03:55,912 --> 01:03:58,648 I'D LIKE ALL OF YOU, NOT JUST 1603 01:03:58,648 --> 01:03:59,983 THE NIAAA COUNCIL MEMBERS BUT I 1604 01:03:59,983 --> 01:04:01,618 WOULD APPRECIATE IT EVEN IF THE 1605 01:04:01,618 --> 01:04:03,253 NIDA COUNCIL MEMBERS WOULD ACT 1606 01:04:03,253 --> 01:04:05,989 AS AMBASSADORS TO LET PEOPLE 1607 01:04:05,989 --> 01:04:07,824 KNOW THAT THESE EXIST. 1608 01:04:07,824 --> 01:04:10,260 RETHINKING DRINKING, A POPULAR 1609 01:04:10,260 --> 01:04:12,996 WEBSITE FOR THE PUBLIC. 1610 01:04:12,996 --> 01:04:14,864 AND IT JUST BASICALLY HELPS YOU 1611 01:04:14,864 --> 01:04:18,001 EVALUATE YOUR RELATIONSHIP WITH 1612 01:04:18,001 --> 01:04:18,534 ALCOHOL. 1613 01:04:18,534 --> 01:04:20,737 COLLEGE AIM IS INFORMATION ON 1614 01:04:20,737 --> 01:04:22,171 PREVENTION APPROACHES, EFFECTIVE 1615 01:04:22,171 --> 01:04:23,273 IN COLLEGE ENVIRONMENTS. 1616 01:04:23,273 --> 01:04:25,008 IF YOU'RE SENDING A CHILD TO 1617 01:04:25,008 --> 01:04:27,210 COLLEGE, LOOK AT IT YOURSELF, 1618 01:04:27,210 --> 01:04:29,212 NOT JUST WAIT FOR THE UNIVERSITY 1619 01:04:29,212 --> 01:04:31,581 ADMINISTRATORS TO LOOK AT IT. 1620 01:04:31,581 --> 01:04:33,750 THE ALCOHOL TREATMENT NAVIGATOR 1621 01:04:33,750 --> 01:04:35,418 IS A RESOURCE THAT HELPS 1622 01:04:35,418 --> 01:04:36,719 INDIVIDUALS UNDERSTAND AND 1623 01:04:36,719 --> 01:04:39,022 SEARCH FOR TREATMENT OPTIONS 1624 01:04:39,022 --> 01:04:39,956 INCLUDING TELEHEALTH SERVICES, 1625 01:04:39,956 --> 01:04:41,958 ALSO INCLUDES PORTAL TO ASSIST 1626 01:04:41,958 --> 01:04:43,960 HEALTHCARE PROVIDERS IN MAKING 1627 01:04:43,960 --> 01:04:45,695 REFERRALS FOR THEIR PATIENTS. 1628 01:04:45,695 --> 01:04:47,764 MANY OF YOU KNOW YOU CAN FIND 1629 01:04:47,764 --> 01:04:56,406 OUT WHAT IS A SPECTRUM USE 1630 01:04:56,406 --> 01:04:58,041 DISORDER, YOU CAN FIND ABOUT 1631 01:04:58,041 --> 01:04:59,342 SPECTRUM OF TREATMENT AND TYPE 1632 01:04:59,342 --> 01:05:02,645 YOUR ZIP CODE IN THE LOCATOR AND 1633 01:05:02,645 --> 01:05:04,280 FIND A TREATMENT FACILITY. 1634 01:05:04,280 --> 01:05:07,750 AND LATEST ONE IS HEALTHCARE 1635 01:05:07,750 --> 01:05:08,451 PROFESSIONAL CORE RESOURCE, I 1636 01:05:08,451 --> 01:05:10,186 TOLD YOU ABOUT THIS BEFORE BUT 1637 01:05:10,186 --> 01:05:11,721 I'LL KEEP TELLING PEOPLE ABOUT 1638 01:05:11,721 --> 01:05:12,488 IT. 1639 01:05:12,488 --> 01:05:13,589 IT'S AN ONLINE EDUCATIONAL 1640 01:05:13,589 --> 01:05:15,258 RESOURCE THAT COVERS BASICS OF 1641 01:05:15,258 --> 01:05:17,860 WHAT EVERY HEALTH CARE 1642 01:05:17,860 --> 01:05:18,828 PROFESSIONAL SHOULD KNOW ABOUT 1643 01:05:18,828 --> 01:05:21,664 ALCOHOL, OR NEEDS TO KNOW ABOUT 1644 01:05:21,664 --> 01:05:22,031 ALCOHOL. 1645 01:05:22,031 --> 01:05:23,666 AND INCLUDING MANY WAYS THAT 1646 01:05:23,666 --> 01:05:25,501 ALCOHOL CAN IMPACT A PATIENT'S 1647 01:05:25,501 --> 01:05:26,803 HEALTH AND PROVIDE STRATEGIES 1648 01:05:26,803 --> 01:05:28,338 FOR ALCOHOL SCREENING AND 1649 01:05:28,338 --> 01:05:28,671 INTERVENTIONS. 1650 01:05:28,671 --> 01:05:31,641 AND IT SHOULD BE GOOD FOR 1651 01:05:31,641 --> 01:05:32,709 ANYBODY, FOR THAT MATTER. 1652 01:05:32,709 --> 01:05:35,878 IT WAS AIMED AT PRIMARY CARE 1653 01:05:35,878 --> 01:05:37,547 DOCS BUT ANY INDIVIDUAL WANTS TO 1654 01:05:37,547 --> 01:05:38,715 KNOW ANYTHING ABOUT ALCOHOL, 1655 01:05:38,715 --> 01:05:40,917 IT'S IN THERE. 1656 01:05:40,917 --> 01:05:43,019 IT'S DOCUMENTED. 1657 01:05:43,019 --> 01:05:43,886 AND REFERENCED. 1658 01:05:43,886 --> 01:05:46,756 WE HAVE A NEW WEBSITE, WEB 1659 01:05:46,756 --> 01:05:48,725 RESOURCES FOR YOUTH PREVENTION, 1660 01:05:48,725 --> 01:05:51,127 WE HAVE NIAAA FOR MIDDLE SCHOOL, 1661 01:05:51,127 --> 01:05:52,095 CONTAINS INTERACTIVE ACTIVITIES 1662 01:05:52,095 --> 01:05:54,630 TO HELP PARENTS, CAREGIVERS AND 1663 01:05:54,630 --> 01:06:01,537 TEACHERS INTRODUCE AND REINFORCE 1664 01:06:01,537 --> 01:06:07,310 KEY MESSAGES ABOUT PEER 1665 01:06:07,310 --> 01:06:08,845 PRESSURE, RESISTANCE, HOW 1666 01:06:08,845 --> 01:06:09,712 ALCOHOL AFFECTS YOUR HELP, 1667 01:06:09,712 --> 01:06:12,915 WARNING SIGNS AND SYMPTOMS, 1668 01:06:12,915 --> 01:06:14,884 WHERE TO GET HELP. 1669 01:06:14,884 --> 01:06:17,420 YOU CAN VISIT OUR WEBSITE, IT'S 1670 01:06:17,420 --> 01:06:17,854 SIMPLE. 1671 01:06:17,854 --> 01:06:22,959 NORA AND I WERE TALKING HOW GOOD 1672 01:06:22,959 --> 01:06:25,294 GOOGLE IS. 1673 01:06:25,294 --> 01:06:27,263 IF YOU TYPE NIAAA IN, YOU COME 1674 01:06:27,263 --> 01:06:28,564 TO OUR WEBSITE SO PLEASE USE IT. 1675 01:06:28,564 --> 01:06:31,634 THANK YOU VERY MUCH. 1676 01:06:31,634 --> 01:06:37,640 1677 01:06:37,640 --> 01:06:47,683 1678 01:07:03,032 --> 01:07:03,566 >> BESIDES THE MEDITERRANEAN 1679 01:07:03,566 --> 01:07:05,868 DIET IS THERE ANY OBJECTIVE 1680 01:07:05,868 --> 01:07:08,571 INFORMATION FROM OTHER REGIONS 1681 01:07:08,571 --> 01:07:10,973 WHERE LIFESPAN IS PROLONGED BLUE 1682 01:07:10,973 --> 01:07:12,308 ZONE SUCH AS OKINAWA FOR EXAMPLE 1683 01:07:12,308 --> 01:07:14,610 THAT PERHAPS PROVIDE BASIS FOR 1684 01:07:14,610 --> 01:07:19,282 FURTHER ACTIONABLE RESEARCH AND 1685 01:07:19,282 --> 01:07:19,649 INTERVENTION? 1686 01:07:19,649 --> 01:07:23,653 >> MOST OF THE DATA WE KNOW, THE 1687 01:07:23,653 --> 01:07:25,521 J-SHAPED CURVE DISAPPEARS WHEN 1688 01:07:25,521 --> 01:07:30,993 YOU ACCOUNT FOR OTHER VARIABLES 1689 01:07:30,993 --> 01:07:32,028 SUCH AS THE SICK ABSTINENT 1690 01:07:32,028 --> 01:07:33,529 INDIVIDUALS, NEVER ACCOUNTED 1691 01:07:33,529 --> 01:07:34,497 FOR. 1692 01:07:34,497 --> 01:07:36,599 IF YOU DO COMPARISON BETWEEN 1693 01:07:36,599 --> 01:07:38,334 MODERATE DRINKERS DEFINED BY 1694 01:07:38,334 --> 01:07:40,303 DIETARY GUIDELINES AND 1695 01:07:40,303 --> 01:07:42,104 INDIVIDUALS WHO WERE DRINKING 1696 01:07:42,104 --> 01:07:44,907 WINE, AND THOSE THAT ARE NOT, IN 1697 01:07:44,907 --> 01:07:46,476 THE MODERATE DRINKING CATEGORY, 1698 01:07:46,476 --> 01:07:50,179 THE J-SHAPED CURVE OR BENEFITS 1699 01:07:50,179 --> 01:07:51,481 OF ALCOHOL FALL, FALL OFF. 1700 01:07:51,481 --> 01:07:52,882 I HATE TO BREAK THE NEWS TO 1701 01:07:52,882 --> 01:07:54,317 EVERYBODY BUT THAT'S THE WAY IT 1702 01:07:54,317 --> 01:07:54,550 IS. 1703 01:07:54,550 --> 01:07:56,919 YOU KNOW, WHEN I GO OUT TO 1704 01:07:56,919 --> 01:07:58,354 DINNER WITH MY FELLOW I.C. 1705 01:07:58,354 --> 01:08:00,122 DIRECTORS THEY WAIT FOR ME TO 1706 01:08:00,122 --> 01:08:01,224 ORDER A GLASS OF WINE BECAUSE 1707 01:08:01,224 --> 01:08:03,659 THEY ARE TERRIFIED I'M GOING TO 1708 01:08:03,659 --> 01:08:03,993 SAY SOMETHING. 1709 01:08:03,993 --> 01:08:06,462 BUT I DO ORDER A GLASS OF WINE 1710 01:08:06,462 --> 01:08:09,232 OCCASIONALLY, ALL RIGHT? 1711 01:08:09,232 --> 01:08:14,470 SO I THINK, YOU KNOW, I'M SURE 1712 01:08:14,470 --> 01:08:19,275 THERE ARE HEALTH UN-BENEFITS TO 1713 01:08:19,275 --> 01:08:21,577 EATING FRITO CORN CHIPS BUT WHEN 1714 01:08:21,577 --> 01:08:22,678 SOMEBODY SERVES THEM AT A PARTY 1715 01:08:22,678 --> 01:08:25,414 WHAT AM I GOING TO DO, WHAT ARE 1716 01:08:25,414 --> 01:08:26,849 YOU GOING TO DO? 1717 01:08:26,849 --> 01:08:28,351 THERE'S REALLY NO HEALTH 1718 01:08:28,351 --> 01:08:29,452 BENEFITS TO ALCOHOL. 1719 01:08:29,452 --> 01:08:31,187 HONESTLY A REPORTING ASKED ME 1720 01:08:31,187 --> 01:08:34,257 RECENTLY, I DON'T SEE ANY WAY TO 1721 01:08:34,257 --> 01:08:37,026 STUDY THAT THAT'S REALLY WORTH 1722 01:08:37,026 --> 01:08:37,994 THE RESOURCES WHEN WE HAVE SO 1723 01:08:37,994 --> 01:08:39,729 MANY OTHER THINGS TO PAY 1724 01:08:39,729 --> 01:08:42,131 ATTENTION TO. 1725 01:08:42,131 --> 01:08:44,667 >> THANK YOU SO MUCH FOR THAT 1726 01:08:44,667 --> 01:08:45,001 PRESENTATION. 1727 01:08:45,001 --> 01:08:48,271 AND I JUST WANT TO THANK YOU FOR 1728 01:08:48,271 --> 01:08:50,706 THE COMPREHENSIVE PRESENTATION 1729 01:08:50,706 --> 01:08:51,774 ABOUT WOMEN'S HEALTH, WHICH IS, 1730 01:08:51,774 --> 01:08:53,643 YOU KNOW, I'M REALLY HAPPY TO 1731 01:08:53,643 --> 01:08:54,110 SEE. 1732 01:08:54,110 --> 01:08:56,078 IT'S VERY LONG OVERDUE. 1733 01:08:56,078 --> 01:08:58,347 AND I'M VERY HAPPY WITH THE 1734 01:08:58,347 --> 01:09:01,617 LEADERSHIP AT NIAAA TO LEAD THAT 1735 01:09:01,617 --> 01:09:02,318 FORWARD. 1736 01:09:02,318 --> 01:09:05,888 I-- THE ENORMITY OF THE PROBLEM 1737 01:09:05,888 --> 01:09:07,690 IS IT'S STUNNING, ACTUALLY. 1738 01:09:07,690 --> 01:09:10,459 AND I THINK THAT I WAS TRYING TO 1739 01:09:10,459 --> 01:09:11,627 THINK ABOUT, YOU KNOW, HOW WE 1740 01:09:11,627 --> 01:09:13,996 WIND OUR WAY OUT OF THIS, GIVEN 1741 01:09:13,996 --> 01:09:15,731 WHERE WE'VE GOTTEN TO AT THIS 1742 01:09:15,731 --> 01:09:16,399 POINT. 1743 01:09:16,399 --> 01:09:18,034 AND JUST A COUPLE THINGS. 1744 01:09:18,034 --> 01:09:20,770 YOU KNOW, WE TALK ABOUT THE 1745 01:09:20,770 --> 01:09:21,571 SOCIAL DETERMINANTS OF HEALTH, I 1746 01:09:21,571 --> 01:09:23,406 THINK W.H.O. TALKS ABOUT THE 1747 01:09:23,406 --> 01:09:24,473 COMMERCIAL DETERMINANTS OF 1748 01:09:24,473 --> 01:09:26,242 HEALTH AS WELL, AND I THINK THAT 1749 01:09:26,242 --> 01:09:29,879 MAKES IT VERY DIFFICULT FOR THE 1750 01:09:29,879 --> 01:09:31,380 SCIENTIFIC COMMUNITY, THE PUBLIC 1751 01:09:31,380 --> 01:09:33,482 HEALTH COMMUNITY, AND MEDICAL 1752 01:09:33,482 --> 01:09:34,684 COMMUNITY TO INTERVENE IN THE 1753 01:09:34,684 --> 01:09:36,252 WAYS WE WISH TO. 1754 01:09:36,252 --> 01:09:38,321 SO, I WAS THINKING ABOUT LIKE 1755 01:09:38,321 --> 01:09:39,855 WITH REGARD TO NIAAA AND 1756 01:09:39,855 --> 01:09:43,659 RESEARCH, AND I KNOW YOU'VE 1757 01:09:43,659 --> 01:09:46,662 TALKED ABOUT IMPLEMENTATION 1758 01:09:46,662 --> 01:09:47,163 RESEARCH, IMPLEMENTATION 1759 01:09:47,163 --> 01:09:47,396 SCIENCE. 1760 01:09:47,396 --> 01:09:51,133 I THINK SO MANY OF THESE FACTS 1761 01:09:51,133 --> 01:09:53,569 ARE SO NOT PART OF THE MEDICAL 1762 01:09:53,569 --> 01:09:54,203 COMMUNITY'S AWARENESS AND I 1763 01:09:54,203 --> 01:09:56,839 THINK IF THERE'S GOING TO BE ANY 1764 01:09:56,839 --> 01:09:59,475 CHANGE IT MEANS THAT EVERY 1765 01:09:59,475 --> 01:10:00,910 SINGLE TOUCH POINT IN THE 1766 01:10:00,910 --> 01:10:02,411 MEMORIAL COMMUNITY WITH EVERY 1767 01:10:02,411 --> 01:10:05,247 SINGLE WOMAN ACTUALLY NEEDS TO 1768 01:10:05,247 --> 01:10:06,248 INCLUDE THIS CONVERSATION. 1769 01:10:06,248 --> 01:10:08,551 BUT HOW DO YOU GET FROM HERE TO 1770 01:10:08,551 --> 01:10:08,751 THERE? 1771 01:10:08,751 --> 01:10:12,388 I WOULD SAY, YOU KNOW, SINCE 1772 01:10:12,388 --> 01:10:13,255 WE'RE TALKING ABOUT RESEARCH, 1773 01:10:13,255 --> 01:10:15,124 ANY TYPE OF RESEARCH NOW ABOUT 1774 01:10:15,124 --> 01:10:19,061 IMPLEMENTATION AS TO WHAT WOULD 1775 01:10:19,061 --> 01:10:22,098 BE SUCCESSFUL IN ASSISTING 1776 01:10:22,098 --> 01:10:23,532 MEDICAL PROFESSIONALS TO BE ABLE 1777 01:10:23,532 --> 01:10:25,835 TO HAVE THESE CONVERSATIONS EVEN 1778 01:10:25,835 --> 01:10:27,803 IF THEY ARE LITERALLY 60 1779 01:10:27,803 --> 01:10:30,973 SECONDS, 60-SECOND CONVERSATION 1780 01:10:30,973 --> 01:10:32,308 WITH A HANDOUT, NONE OF THAT 1781 01:10:32,308 --> 01:10:34,810 TAKES PLACE IN MOST MEDICAL 1782 01:10:34,810 --> 01:10:35,144 SETTINGS. 1783 01:10:35,144 --> 01:10:41,283 BUT, YOU KNOW, WOMEN AND GIRLS, 1784 01:10:41,283 --> 01:10:41,884 PEDIATRICIANS, OBSTETRICIANS, 1785 01:10:41,884 --> 01:10:43,919 PRIMARY CARE, MENTAL HEALTH 1786 01:10:43,919 --> 01:10:44,553 CLINICIANS, THESE CONVERSATIONS 1787 01:10:44,553 --> 01:10:45,755 DO NOT HAPPEN. 1788 01:10:45,755 --> 01:10:49,058 THE MEDICAL COMMUNITY IS NOT 1789 01:10:49,058 --> 01:10:50,026 AWARE OF THESE FACTS. 1790 01:10:50,026 --> 01:10:52,294 I WOULD JUST SAY THAT WE HAVE A 1791 01:10:52,294 --> 01:10:56,899 LOT TO DO. 1792 01:10:56,899 --> 01:10:58,768 IT'S ONLY WORSENED DURING THE 1793 01:10:58,768 --> 01:10:59,735 PANDEMIC AND POST-PANDEMIC. 1794 01:10:59,735 --> 01:11:02,271 THERE WAS TREMENDOUS AMOUNTS OF 1795 01:11:02,271 --> 01:11:05,207 DIRECT ADVERTISING TO PEOPLE, 1796 01:11:05,207 --> 01:11:08,811 YOU KNOW, AROUND THE STRESS OF 1797 01:11:08,811 --> 01:11:09,478 THE PANDEMIC. 1798 01:11:09,478 --> 01:11:11,881 WE'RE IN THE PLACE WE ARE, I CAN 1799 01:11:11,881 --> 01:11:15,851 ONLY SEE ONE STRATEGY IS THAT 1800 01:11:15,851 --> 01:11:16,819 THE MEDICAL COMMUNITY BE MUCH 1801 01:11:16,819 --> 01:11:18,921 MORE AWARE AND ABLE TO HAVE 1802 01:11:18,921 --> 01:11:19,255 THAT. 1803 01:11:19,255 --> 01:11:21,624 REGARDING RESEARCH I THINK, YOU 1804 01:11:21,624 --> 01:11:22,525 KNOW, IMPLEMENTATION SCIENCE 1805 01:11:22,525 --> 01:11:24,226 WHERE WE EXPERIMENT WITH HOW CAN 1806 01:11:24,226 --> 01:11:26,796 WE BEST -- WHAT ARE THE BEST 1807 01:11:26,796 --> 01:11:28,898 APPROACHES TO HAVING THIS HAPPEN 1808 01:11:28,898 --> 01:11:30,633 MIGHT BE ONE APPROACH, AMONG 1809 01:11:30,633 --> 01:11:32,168 OTHERS, I'M SURE. 1810 01:11:32,168 --> 01:11:35,438 SO I JUST AGAIN WANT TO THANK 1811 01:11:35,438 --> 01:11:36,772 YOU FOR THE WHOLE PERSON CONCEPT 1812 01:11:36,772 --> 01:11:38,607 AND FOR WOMEN'S HEALTH AND FOR 1813 01:11:38,607 --> 01:11:43,746 JUST LEADING THIS EFFORT WHICH 1814 01:11:43,746 --> 01:11:45,181 IS INCREDIBLY IMPORTANT FOR THE 1815 01:11:45,181 --> 01:11:47,583 HEALTH OF THE ENTIRE COMMUNITY. 1816 01:11:47,583 --> 01:11:47,883 >> THANKS. 1817 01:11:47,883 --> 01:11:52,722 YEAH, WE'RE WORKING ON IT. 1818 01:11:52,722 --> 01:11:54,790 WE DID DISCUSS THIS IN DETAIL 1819 01:11:54,790 --> 01:11:56,192 YESTERDAY, AND I DON'T WANT TO 1820 01:11:56,192 --> 01:11:59,795 TAKE UP THE TIME NOW, BUT OUR 1821 01:11:59,795 --> 01:12:02,164 COUNCIL IS WHERE YOU ARE. 1822 01:12:02,164 --> 01:12:02,364 DAVE? 1823 01:12:02,364 --> 01:12:04,333 REAL QUICK BECAUSE WE HAVE TO 1824 01:12:04,333 --> 01:12:05,701 MOVE ON. 1825 01:12:05,701 --> 01:12:08,270 >> I WAS STARING AT THE SLIDE, 1826 01:12:08,270 --> 01:12:09,805 WHERE WOMEN START TO SURPASS 1827 01:12:09,805 --> 01:12:09,972 MEN. 1828 01:12:09,972 --> 01:12:17,146 I WONDER IF THERE MIGHT BE 1829 01:12:17,146 --> 01:12:18,347 ANOTHER INTERPRETATION, IT 1830 01:12:18,347 --> 01:12:20,082 SEEMED MEN WERE DECLINING 1831 01:12:20,082 --> 01:12:22,718 FASTER, WOMEN WERE DECLINING 1832 01:12:22,718 --> 01:12:25,454 SLOWER RATHER THAN OUTRIGHT 1833 01:12:25,454 --> 01:12:30,259 INCREASE IN WOMEN, WONDER IF 1834 01:12:30,259 --> 01:12:32,128 THERE MIGHT BE SOCIOLOGIC BASIS 1835 01:12:32,128 --> 01:12:34,163 BEHIND THAT FOR FUTURE RESEARCH 1836 01:12:34,163 --> 01:12:35,364 REGARDING GENDER ROLES IN 1837 01:12:35,364 --> 01:12:36,499 SOCIETY OR SOMETHING. 1838 01:12:36,499 --> 01:12:38,467 >> YEAH, NO, I THINK IT'S A 1839 01:12:38,467 --> 01:12:39,535 VALID POINT. 1840 01:12:39,535 --> 01:12:43,072 BUT THE FACT OF THE MATTER IS 1841 01:12:43,072 --> 01:12:44,907 BECAUSE WOMEN HAVE MORE 1842 01:12:44,907 --> 01:12:45,474 PATHOLOGY ASSOCIATED WITH 1843 01:12:45,474 --> 01:12:48,744 ALCOHOL AND IF THEY ARE DRINKING 1844 01:12:48,744 --> 01:12:50,713 THE SAME AMOUNT AS MEN THEY CAN 1845 01:12:50,713 --> 01:12:52,681 GET HIGHER BLOOD ALCOHOL LEVELS, 1846 01:12:52,681 --> 01:12:54,216 IT REALLY IS A TOUCH POINT THAT 1847 01:12:54,216 --> 01:12:57,286 WE'RE STILL GOING TO HAVE TO 1848 01:12:57,286 --> 01:13:00,823 STRUGGLE WITH. 1849 01:13:00,823 --> 01:13:07,363 I'M GOING TO STOP. 1850 01:13:07,363 --> 01:13:09,098 >> I'LL JUST MAKE A POINT. 1851 01:13:09,098 --> 01:13:11,500 WE'VE BEEN FOCUSED ON THE SOCIAL 1852 01:13:11,500 --> 01:13:13,369 DETERMINANTS OF HEALTH, AS WE 1853 01:13:13,369 --> 01:13:15,437 SHOULD, BUT LISTENING TO YOUR 1854 01:13:15,437 --> 01:13:18,507 PRESENTATION, ALSO RELEVANT FOR 1855 01:13:18,507 --> 01:13:19,275 OTHERS, ANOTHER COMPONENT WE 1856 01:13:19,275 --> 01:13:21,477 SHOULD BE USING MORE IN 1857 01:13:21,477 --> 01:13:22,344 NARRATIVE AND TO A CERTAIN 1858 01:13:22,344 --> 01:13:25,748 EXTENT HOW DO WE DEAL WITH THE 1859 01:13:25,748 --> 01:13:28,484 ECONOMIC INTERESTS BEHIND THE 1860 01:13:28,484 --> 01:13:29,351 ALCOHOL INDUSTRY, COMMERCIAL 1861 01:13:29,351 --> 01:13:30,019 DETERMINANTS OF HEALTH. 1862 01:13:30,019 --> 01:13:32,254 I THINK THAT'S JUST AS WE SPEAK 1863 01:13:32,254 --> 01:13:33,756 OF SOCIAL DETERMINANTS OF HEALTH 1864 01:13:33,756 --> 01:13:38,027 WE NEED TO ACTUALLY START TO 1865 01:13:38,027 --> 01:13:39,461 DESCRIBE THESE MORE EXPLICITLY 1866 01:13:39,461 --> 01:13:41,630 BECAUSE THE HEALTH OF 1867 01:13:41,630 --> 01:13:43,499 INDIVIDUALS IS ACTUALLY BEING 1868 01:13:43,499 --> 01:13:45,067 DISRUPTED BY COMMERCIAL 1869 01:13:45,067 --> 01:13:46,368 INTERESTS. 1870 01:13:46,368 --> 01:13:48,971 SO YOU HAVE ABSOLUTELY OBESITY, 1871 01:13:48,971 --> 01:13:50,406 ALCOHOL, AND DRUGS. 1872 01:13:50,406 --> 01:13:54,944 AND SORT OF THIS GIGANTIC 1873 01:13:54,944 --> 01:13:56,645 INTEREST, AND TACKLES TO THE 1874 01:13:56,645 --> 01:14:00,349 CONCEPT OF HOW -- WHAT POLICIES 1875 01:14:00,349 --> 01:14:01,784 CAN BE CONSTRUCTIVE, SO THE 1876 01:14:01,784 --> 01:14:04,854 POINT THAT I THINK THAT SPEAKING 1877 01:14:04,854 --> 01:14:07,590 ABOUT COMMERCIAL DETERMINANTS OF 1878 01:14:07,590 --> 01:14:10,125 HEALTH CAN MAKE POLICY MOVE 1879 01:14:10,125 --> 01:14:13,495 TOWARDS BETTER REGULATION OF 1880 01:14:13,495 --> 01:14:13,762 PRODUCTS. 1881 01:14:13,762 --> 01:14:15,364 >> GIVEN MY INTERACTIONS WITH 1882 01:14:15,364 --> 01:14:17,299 THE BEVERAGE INDUSTRY I THINK 1883 01:14:17,299 --> 01:14:18,734 NORA, THIS IS A REALLY GOOD 1884 01:14:18,734 --> 01:14:18,934 IDEA. 1885 01:14:18,934 --> 01:14:29,478 BUT I'M GOING TO BE RIGHT BEHIND 1886 01:14:31,847 --> 01:14:31,947 YOU. 1887 01:14:31,947 --> 01:14:33,816 IT'S A JOKE BUT SERIOUSLY YOU 1888 01:14:33,816 --> 01:14:35,651 KNOW EXACTLY WHAT I'M TALKING 1889 01:14:35,651 --> 01:14:36,685 ABOUT. 1890 01:14:36,685 --> 01:14:37,253 >> YEAH. 1891 01:14:37,253 --> 01:14:41,357 >> WHEN WE INTERACT WITH THESE 1892 01:14:41,357 --> 01:14:43,926 ENTITIES, THERE'S ALWAYS, YOU 1893 01:14:43,926 --> 01:14:46,996 KNOW, A NUANCED WAY WE CAN DO IT 1894 01:14:46,996 --> 01:14:48,130 WITHOUT GETTING IN TROUBLE. 1895 01:14:48,130 --> 01:14:51,600 SO THAT'S WHAT I'M TRYING TO 1896 01:14:51,600 --> 01:14:54,003 THINK, HOW DO WE -- WE'RE WELL 1897 01:14:54,003 --> 01:14:55,304 AWARE, THE RESEARCH HAS BEEN 1898 01:14:55,304 --> 01:14:56,939 DONE, IF YOU INCREASE 1899 01:14:56,939 --> 01:14:58,707 ADVERTISING TOWARD YOUNG PEOPLE 1900 01:14:58,707 --> 01:15:00,009 THEY DRINK MORE. 1901 01:15:00,009 --> 01:15:01,777 WE KNOW IF YOU INCREASE 1902 01:15:01,777 --> 01:15:04,380 AVAILABILITY OF OUTLETS FOR 1903 01:15:04,380 --> 01:15:05,214 ALCOHOL, THEY DRINK MORE, IN 1904 01:15:05,214 --> 01:15:06,482 THAT PART OF THE TOWN. 1905 01:15:06,482 --> 01:15:09,418 I REMEMBER A GENTLEMAN TELLING 1906 01:15:09,418 --> 01:15:12,054 ME AFTER THE RIOTS IN LOS 1907 01:15:12,054 --> 01:15:13,255 ANGELES, 20 YEARS AGO, THAT THE 1908 01:15:13,255 --> 01:15:15,557 FIRST THING THAT CAME BACK 1909 01:15:15,557 --> 01:15:18,160 WASN'T THE SUPERMARKETS OR SMALL 1910 01:15:18,160 --> 01:15:18,794 STORES, CONVENIENCE STORES FOR 1911 01:15:18,794 --> 01:15:20,462 DELIVERING FOOD. 1912 01:15:20,462 --> 01:15:24,099 IT WAS THE LIQUOR STORES, OKAY? 1913 01:15:24,099 --> 01:15:25,467 YOU'RE ABSOLUTELY RIGHT IS WHAT 1914 01:15:25,467 --> 01:15:27,703 I'M SAYING BUT HOW DO WE ADDRESS 1915 01:15:27,703 --> 01:15:31,307 THIS IN A CURRENT POLITICAL 1916 01:15:31,307 --> 01:15:32,107 ATMOSPHERE AND POLARIZATIONS, 1917 01:15:32,107 --> 01:15:35,878 ALL THIS STUFF, IS GOING TO BE 1918 01:15:35,878 --> 01:15:36,345 TRICKY. 1919 01:15:36,345 --> 01:15:37,313 >> I AGREE. 1920 01:15:37,313 --> 01:15:38,881 IT'S NOT BLACK AND WHITE. 1921 01:15:38,881 --> 01:15:41,250 ONE WAY IT COULD BE HELPFUL IS 1922 01:15:41,250 --> 01:15:45,721 GET JUST LIKE YOU WERE SHOWING 1923 01:15:45,721 --> 01:15:47,256 AN ESTIMATE OF CANCERS BY 1924 01:15:47,256 --> 01:15:48,791 ALCOHOL, CANCERS FROM ALCOHOL, 1925 01:15:48,791 --> 01:15:51,093 WE HAVE CANCERS FROM SMOKING, WE 1926 01:15:51,093 --> 01:15:55,931 HAVE THE CANCERS FROM OBESITY. 1927 01:15:55,931 --> 01:15:58,000 THAT BECOMES A VERY NOTABLE 1928 01:15:58,000 --> 01:15:59,635 NUMBER, AND PEOPLE DON'T, AS YOU 1929 01:15:59,635 --> 01:16:00,269 SAY, DON'T KNOW. 1930 01:16:00,269 --> 01:16:02,471 I THINK THIS IS A WAY, WE DON'T 1931 01:16:02,471 --> 01:16:04,239 SAY ANYTHING, WE JUST LET IT BE 1932 01:16:04,239 --> 01:16:06,976 THERE AND BECOME VERY, VERY 1933 01:16:06,976 --> 01:16:07,476 EVIDENT BUT -- 1934 01:16:07,476 --> 01:16:10,913 >> MAYBE BILL CAN HELP US. 1935 01:16:10,913 --> 01:16:12,448 >> YES, BILL, PLEASE. 1936 01:16:12,448 --> 01:16:14,316 I APOLOGIZE FOR ASKING THAT 1937 01:16:14,316 --> 01:16:14,583 QUESTION. 1938 01:16:14,583 --> 01:16:16,118 >> NO, IT'S AN IMPORTANT ONE AND 1939 01:16:16,118 --> 01:16:17,353 ONE WE SPEND A LOT OF TIME 1940 01:16:17,353 --> 01:16:19,254 THINKING ABOUT. 1941 01:16:19,254 --> 01:16:22,157 GOOD MORNING, EVERYBODY. 1942 01:16:22,157 --> 01:16:24,493 I'M BILL KLEIN, ASSOCIATE 1943 01:16:24,493 --> 01:16:28,330 DIRECTOR OF BEHAVIORAL RESEARCH 1944 01:16:28,330 --> 01:16:30,666 AT NCI, 30 TO 50% OF CANCERS ARE 1945 01:16:30,666 --> 01:16:32,735 ATTRIBUTABLE TO BEHAVIOR, MOST 1946 01:16:32,735 --> 01:16:33,602 STAFF ARE BEHAVIORAL SCIENTISTS, 1947 01:16:33,602 --> 01:16:35,871 SPEND TIME THINKING ABOUT HEALTH 1948 01:16:35,871 --> 01:16:38,640 BEHAVIOR AND CHANGE AND ETIOLOGY 1949 01:16:38,640 --> 01:16:39,742 OF BEHAVIOR. 1950 01:16:39,742 --> 01:16:41,143 SO, I ALSO WANT TO SAY TO GEORGE 1951 01:16:41,143 --> 01:16:43,879 THAT I'VE BEEN IN THE SAME BOAT 1952 01:16:43,879 --> 01:16:44,913 AT DINNER PARTIES. 1953 01:16:44,913 --> 01:16:49,785 EVERYONE LOOKING AT ME AND MY 1954 01:16:49,785 --> 01:16:51,320 COLLEAGUE DAVID BARRIGAN AS 1955 01:16:51,320 --> 01:16:52,421 WELL, OFTEN PEOPLE ARE LOOKING 1956 01:16:52,421 --> 01:16:54,289 TO US FIRST, IS IT OKAY TO GET A 1957 01:16:54,289 --> 01:16:54,823 GLASS OF WINE? 1958 01:16:54,823 --> 01:16:56,258 WE TALK ABOUT THE FACT ALL 1959 01:16:56,258 --> 01:17:04,233 THINGS ARE FINE IN MODERATION, 1960 01:17:04,233 --> 01:17:05,200 FRITO'S TOO, BUT WE SHOULDN'T GO 1961 01:17:05,200 --> 01:17:06,902 INTO IT THINKING ALCOHOL IS 1962 01:17:06,902 --> 01:17:11,774 HEALTHY AND SOMEHOW IS HELPING 1963 01:17:11,774 --> 01:17:12,441 US. 1964 01:17:12,441 --> 01:17:14,610 I'M AMAZED IT'S BEEN 11 YEARS 1965 01:17:14,610 --> 01:17:17,813 FOR CRAN, NCI HAS BEEN A WILLING 1966 01:17:17,813 --> 01:17:18,113 PARTICIPANT. 1967 01:17:18,113 --> 01:17:19,782 IT WAS AT FIRST BECAUSE WE DO 1968 01:17:19,782 --> 01:17:22,718 TOBACCO, WE HAVE THE LEADING 1969 01:17:22,718 --> 01:17:23,952 TOBACCO GROUP, TOBACCO RESEARCH 1970 01:17:23,952 --> 01:17:25,254 BRANCH, BUT IT'S NOT JUST ABOUT 1971 01:17:25,254 --> 01:17:25,654 TOBACCO. 1972 01:17:25,654 --> 01:17:27,122 WE'VE BEEN DOING WORK IN THE 1973 01:17:27,122 --> 01:17:28,357 ALCOHOL SPACE AND NOW ALSO 1974 01:17:28,357 --> 01:17:31,060 CANNABIS AS WELL. 1975 01:17:31,060 --> 01:17:32,261 SO WE'RE GETTING CLOSER TO 1976 01:17:32,261 --> 01:17:34,029 GETTING INVOLVED IN THE KINDS OF 1977 01:17:34,029 --> 01:17:35,130 DISCUSSIONS THAT NORA AND GEORGE 1978 01:17:35,130 --> 01:17:37,066 AND COLLEAGUES HAVE BEEN 1979 01:17:37,066 --> 01:17:38,500 INVOLVED IN OVER THE LAST MANY 1980 01:17:38,500 --> 01:17:39,368 YEARS. 1981 01:17:39,368 --> 01:17:42,104 I WANT TO DO WHAT NORA DID. 1982 01:17:42,104 --> 01:17:50,412 OH, I'M STUCK HERE NOW TOO. 1983 01:17:50,412 --> 01:17:51,413 OKAY, GOT IT. 1984 01:17:51,413 --> 01:17:53,482 I'LL START BY TALKING ABOUT 1985 01:17:53,482 --> 01:17:53,882 LEADERSHIP. 1986 01:17:53,882 --> 01:17:54,817 IT STARTS AT THE TOP. 1987 01:17:54,817 --> 01:17:57,753 YOU NEED TO HAVE LEADERS 1988 01:17:57,753 --> 01:17:59,588 SUPPORTIVE OF THE PRIORITIES, 1989 01:17:59,588 --> 01:18:00,255 AND THE MISSION. 1990 01:18:00,255 --> 01:18:02,124 AND WE'VE HAD THAT AT NCI OVER 1991 01:18:02,124 --> 01:18:03,992 THE LAST COUPLE YEARS. 1992 01:18:03,992 --> 01:18:04,626 FIRST WITH MONICA BERTAGNOLLI, 1993 01:18:04,626 --> 01:18:07,062 WHO IS NOW THE DIRECTOR OF NIH, 1994 01:18:07,062 --> 01:18:08,263 SHE WAS OUR DIRECTOR FOR LESS 1995 01:18:08,263 --> 01:18:10,799 THAN A YEAR BUT WAS SO TALENTED 1996 01:18:10,799 --> 01:18:13,502 SHE GOT SNATCHED UP, NOW HEADING 1997 01:18:13,502 --> 01:18:14,169 UP NIH. 1998 01:18:14,169 --> 01:18:15,737 AND FORTUNATELY SHE'S BEEN 1999 01:18:15,737 --> 01:18:18,006 REPLACED BY ANOTHER TALENTED 2000 01:18:18,006 --> 01:18:19,441 PERSON, KIM RATHMELL, WHO JOINED 2001 01:18:19,441 --> 01:18:22,911 AT THE END OF 2023, AN 2002 01:18:22,911 --> 01:18:23,912 ONCOLOGIST FROM VANDERBILT, 2003 01:18:23,912 --> 01:18:26,215 SHE'S SPENDING TIME GOING AROUND 2004 01:18:26,215 --> 01:18:26,949 DOING LISTENING TOURS, GETTING 2005 01:18:26,949 --> 01:18:28,383 SENSE OF WHAT THE INSTITUTE IS 2006 01:18:28,383 --> 01:18:29,384 UP TO AND WHAT ISSUES ARE. 2007 01:18:29,384 --> 01:18:34,623 AND I CAN EL YOU SHE'S A QUICK 2008 01:18:34,623 --> 01:18:36,158 STUDY, I'VE TALKED TO HER, 2009 01:18:36,158 --> 01:18:38,694 OTHERS HAVE AS WELL, ABOUT 2010 01:18:38,694 --> 01:18:39,428 IMPORTANCE OF BEHAVIORAL 2011 01:18:39,428 --> 01:18:40,729 SCIENCE, TOBACCO USE OF COURSE, 2012 01:18:40,729 --> 01:18:44,032 WHICH IS A MAJOR ISSUE FOR US AT 2013 01:18:44,032 --> 01:18:44,366 NCI. 2014 01:18:44,366 --> 01:18:45,134 SHE'S LISTENING AND SHE'S 2015 01:18:45,134 --> 01:18:46,869 SUPPORTIVE OF THE WORK WE'RE 2016 01:18:46,869 --> 01:18:47,302 DOING. 2017 01:18:47,302 --> 01:18:48,403 WE THINK THAT'S IMPORTANT. 2018 01:18:48,403 --> 01:18:51,907 I DO WANT TO NOTE THAT MONICA 2019 01:18:51,907 --> 01:18:53,876 WAS THE FIRST WOMAN NCI 2020 01:18:53,876 --> 01:18:54,143 DIRECTOR. 2021 01:18:54,143 --> 01:18:56,178 AFTER ALL THESE YEARS IT'S HARD 2022 01:18:56,178 --> 01:18:57,813 TO BELIEVE IT TOOK THAT LONG. 2023 01:18:57,813 --> 01:19:00,315 WE NOW HAVE KIM AS WELL, WHO IS 2024 01:19:00,315 --> 01:19:00,883 THE SECOND. 2025 01:19:00,883 --> 01:19:02,851 HOPEFULLY THERE WILL BE MANY 2026 01:19:02,851 --> 01:19:03,185 MORE. 2027 01:19:03,185 --> 01:19:03,385 OKAY. 2028 01:19:03,385 --> 01:19:05,587 ALSO I WANT TO MENTION A BIT 2029 01:19:05,587 --> 01:19:06,889 ABOUT LEADERSHIP OF OUR DIVISION 2030 01:19:06,889 --> 01:19:09,591 OF CANCER CONTROL AND POPULATION 2031 01:19:09,591 --> 01:19:11,593 SCIENCES NOW LED BY AS YOU CAN 2032 01:19:11,593 --> 01:19:13,495 SEE ON THE LEFT KATRINA GODDARD. 2033 01:19:13,495 --> 01:19:14,763 WE HAVE FOUR PROGRAMS IN OUR 2034 01:19:14,763 --> 01:19:16,265 DIVISION, ONE IS THE BEHAVIORAL 2035 01:19:16,265 --> 01:19:18,700 RESEARCH PROGRAM THAT I LEAD, WE 2036 01:19:18,700 --> 01:19:20,435 ALSO HAVE THREE OTHERS AND ALL 2037 01:19:20,435 --> 01:19:22,004 THREE OF MY PEER ASSOCIATE 2038 01:19:22,004 --> 01:19:27,342 DIRECTORS HAVE OR ARE ABOUT TO 2039 01:19:27,342 --> 01:19:27,976 RETIRE. 2040 01:19:27,976 --> 01:19:29,511 I HOPE IF YOU HAVE COLLEAGUES OR 2041 01:19:29,511 --> 01:19:31,713 YOU MIGHT BE INTERESTED IN A 2042 01:19:31,713 --> 01:19:32,714 MAJOR LEADERSHIP POSITION WITH 2043 01:19:32,714 --> 01:19:34,983 US, CAN YOU SEE THE HEALTHCARE 2044 01:19:34,983 --> 01:19:37,085 DELIVERY RESEARCH PROGRAM, 2045 01:19:37,085 --> 01:19:37,853 SURVEILLANCE RESEARCH PROGRAM, 2046 01:19:37,853 --> 01:19:42,324 AND EPIDEMIOLOGY AND GENOMICS, 2047 01:19:42,324 --> 01:19:52,701 ALL ARE ABOUT TO OPEN. 2048 01:19:53,569 --> 01:19:55,037 WHEN DR. GODDARD JOINED US ABOUT 2049 01:19:55,037 --> 01:19:58,006 2 1/2 YEARS AGO, WE STARTED A 2050 01:19:58,006 --> 01:19:58,740 STRATEGIC PLANNING PROCESS 2051 01:19:58,740 --> 01:20:02,377 WITHIN THE DIVISION AND FOCUSED 2052 01:20:02,377 --> 01:20:04,112 ON THESE CROSS-CUTTING AREAS OF 2053 01:20:04,112 --> 01:20:04,313 FOCUS. 2054 01:20:04,313 --> 01:20:05,881 I WANTED TO PUT THIS UP THERE, 2055 01:20:05,881 --> 01:20:06,949 IT'S IMPORTANT TO KNOW WHAT 2056 01:20:06,949 --> 01:20:08,283 WE'RE WORKING ON AND THINKING 2057 01:20:08,283 --> 01:20:09,751 ABOUT BUT ALSO BECAUSE ALL OF 2058 01:20:09,751 --> 01:20:11,587 THESE ARE RELEVANT TO THE KINDS 2059 01:20:11,587 --> 01:20:12,888 OF ISSUES WE'RE CONCERNED WITH 2060 01:20:12,888 --> 01:20:15,390 IN CRAN, ALSO THE ABCD STUDY. 2061 01:20:15,390 --> 01:20:17,359 RIGHT ACROSS THE BOARD. 2062 01:20:17,359 --> 01:20:18,560 EVEN CLIMATE CHANGE. 2063 01:20:18,560 --> 01:20:19,661 CLIMB CHANGES IS AFFECTING 2064 01:20:19,661 --> 01:20:20,963 GROWTH OF TOBACCO, RIGHT? 2065 01:20:20,963 --> 01:20:22,931 THAT'S JUST ONE OF MANY POSSIBLE 2066 01:20:22,931 --> 01:20:23,498 EXAMPLES. 2067 01:20:23,498 --> 01:20:25,667 THESE ARE SOME TOPICS THAT ARE 2068 01:20:25,667 --> 01:20:26,902 REALLY OCCUPYING OUR ATTENTION 2069 01:20:26,902 --> 01:20:28,737 OVER THE LAST COUPLE YEARS. 2070 01:20:28,737 --> 01:20:30,706 I WANT TO TELL YOU ABOUT WHAT 2071 01:20:30,706 --> 01:20:32,608 WE'VE BEEN DOING, OVER THE LAST 2072 01:20:32,608 --> 01:20:33,909 COUPLE OF YEARS, ALSO TELL YOU 2073 01:20:33,909 --> 01:20:35,344 ABOUT SOME OF OUR PRIORITIES. 2074 01:20:35,344 --> 01:20:38,180 FIRST OF ALL, SOME THINGS WE'VE 2075 01:20:38,180 --> 01:20:39,381 BEEN DOING INTERNALLY, THESE ARE 2076 01:20:39,381 --> 01:20:41,583 THINGS WE SPEND TIME TALKING 2077 01:20:41,583 --> 01:20:42,317 ABOUT IN HALLWAYS, BECAUSE WE'RE 2078 01:20:42,317 --> 01:20:45,454 NOW BACK IN THE OFFICE AGAIN. 2079 01:20:45,454 --> 01:20:45,687 IMAGINE. 2080 01:20:45,687 --> 01:20:48,056 AND REALLY ARE DRIVING MANY OF 2081 01:20:48,056 --> 01:20:50,025 THE TOPICS THAT LEAD TO FUNDING 2082 01:20:50,025 --> 01:20:51,560 INITIATIVES AND OTHER PROJECTS 2083 01:20:51,560 --> 01:20:52,761 THAT WE PRIORITIZE. 2084 01:20:52,761 --> 01:20:55,264 SO, FIRST OF ALL, YOU MIGHT KNOW 2085 01:20:55,264 --> 01:20:55,864 THAT THE DEPARTMENT OF HEALTH 2086 01:20:55,864 --> 01:20:57,666 AND HUMAN SERVICES HAS JUST COME 2087 01:20:57,666 --> 01:21:01,637 OUT WITH A FRA IMWORK TO SUPPORT 2088 01:21:01,637 --> 01:21:06,241 AND ACCELERATE SMOKING 2089 01:21:06,241 --> 01:21:07,209 CESSATION, NOT MANY 2090 01:21:07,209 --> 01:21:08,644 ADMINISTRATIONS ARE FOCUSED ON 2091 01:21:08,644 --> 01:21:08,977 TOBACCO. 2092 01:21:08,977 --> 01:21:10,279 JOE BIDEN HAS THE CANCER 2093 01:21:10,279 --> 01:21:11,480 MOONSHOT BACK WHEN HE WAS VICE 2094 01:21:11,480 --> 01:21:13,682 PRESIDENT, THAT HAS CONTINUE TO 2095 01:21:13,682 --> 01:21:15,317 BE A PRIORITY. 2096 01:21:15,317 --> 01:21:17,386 AND OUTGROWTH IS FOCUS ON 2097 01:21:17,386 --> 01:21:19,488 SMOKING CESSATION, SOMETHING 2098 01:21:19,488 --> 01:21:21,123 THAT'S A TRANSAGENCY 2099 01:21:21,123 --> 01:21:21,990 CROSS-AGENCY INITIATIVE TO 2100 01:21:21,990 --> 01:21:22,891 ADDRESS TOBACCO CESSATION, USING 2101 01:21:22,891 --> 01:21:26,228 ALL THE TOOLS WE HAVE AT OUR 2102 01:21:26,228 --> 01:21:26,695 DISPOSAL. 2103 01:21:26,695 --> 01:21:30,198 TWO PROGRAM DIRECTORS HAD 2104 01:21:30,198 --> 01:21:33,268 DETAILS, ONE OF OUR GOVERNMENT 2105 01:21:33,268 --> 01:21:34,269 TERMS TO ACKNOWLEDGE WHEN 2106 01:21:34,269 --> 01:21:36,438 SOMEONE SPENDS TIME AT ANOTHER 2107 01:21:36,438 --> 01:21:38,073 INSTITUTE OR ANOTHER AGENCY, SO 2108 01:21:38,073 --> 01:21:39,174 WE'VE HAD TWO PROGRAM DIRECTORS 2109 01:21:39,174 --> 01:21:40,475 SPEND A FAIR AMOUNT OF TIME OVER 2110 01:21:40,475 --> 01:21:43,011 THE LAST YEAR WITH THE OFFICE OF 2111 01:21:43,011 --> 01:21:44,946 ASSISTANT SECRETARY OF HEALTH 2112 01:21:44,946 --> 01:21:46,815 WORKING ON THIS IMPORTANT 2113 01:21:46,815 --> 01:21:47,149 INITIATIVE. 2114 01:21:47,149 --> 01:21:48,350 GEORGE MADE THE POINT THAT YOU 2115 01:21:48,350 --> 01:21:50,552 SHOULD BE USING OUR TOOLS, AS 2116 01:21:50,552 --> 01:21:52,521 WELL AS LOOKING FOR GRANT 2117 01:21:52,521 --> 01:21:53,622 FUNDING, I THINK THAT'S VERY 2118 01:21:53,622 --> 01:21:55,357 IMPORTANT TO ACKNOWLEDGE AND TO 2119 01:21:55,357 --> 01:21:56,024 EMPHASIZE. 2120 01:21:56,024 --> 01:22:01,163 AT NCI WE HAVE A LOT OF TOOLS, 2121 01:22:01,163 --> 01:22:08,036 ONE IS TOBACCO USE SUPPLEMENT 2122 01:22:08,036 --> 01:22:10,038 SURVEY, LINK TO U.S. CENSUS 2123 01:22:10,038 --> 01:22:12,007 WHICH PUTS OUT CURRENT 2124 01:22:12,007 --> 01:22:12,607 POPULATION SURVEY, NOT SAMPLES 2125 01:22:12,607 --> 01:22:14,843 OF A THOUSAND OR TWO THOUSAND, 2126 01:22:14,843 --> 01:22:16,244 WE'RE TALKING TENS OF THOUSANDS 2127 01:22:16,244 --> 01:22:16,511 AND MORE. 2128 01:22:16,511 --> 01:22:19,348 SO THAT'S AN IMPORTANT DATASET 2129 01:22:19,348 --> 01:22:21,083 WE MAKE PUBLICLY AVAILABLE. 2130 01:22:21,083 --> 01:22:22,751 WE'RE CONTINUING AS GEORGE 2131 01:22:22,751 --> 01:22:24,586 ALLUDED TO, TO GO OUT THERE AND 2132 01:22:24,586 --> 01:22:26,855 TALK ABOUT THIS LINK BETWEEN 2133 01:22:26,855 --> 01:22:30,158 ALCOHOL AND CANCER, AND MANY 2134 01:22:30,158 --> 01:22:30,425 CONTEXTS. 2135 01:22:30,425 --> 01:22:32,461 TWO PRESENTATIONS ARE COMING UP 2136 01:22:32,461 --> 01:22:35,530 AT ALCOHOL POLICY CONFERENCE 2137 01:22:35,530 --> 01:22:36,932 NEXT WEEK IN ARLINGTON, I'VE 2138 01:22:36,932 --> 01:22:37,933 BEEN TO THIS MEETING TWO OR 2139 01:22:37,933 --> 01:22:39,801 THREE TIMES AND THE FIRST TIME I 2140 01:22:39,801 --> 01:22:41,103 WENT CANCER WAS NOWHERE IN THE 2141 01:22:41,103 --> 01:22:41,336 PROGRAM. 2142 01:22:41,336 --> 01:22:42,971 NOW IT'S ALL OVER THE PROGRAM. 2143 01:22:42,971 --> 01:22:44,306 SO IT'S CLEAR THAT IT'S REALLY 2144 01:22:44,306 --> 01:22:47,242 HAVING AN IMPACT IN THE POLICY 2145 01:22:47,242 --> 01:22:47,876 SPACE. 2146 01:22:47,876 --> 01:22:49,778 AND THEN WCC, WORLD CANCER 2147 01:22:49,778 --> 01:22:50,746 CONGRESS, AND I WANT TO MENTION 2148 01:22:50,746 --> 01:22:51,947 AS LONG AS THAT'S UP THERE THE 2149 01:22:51,947 --> 01:22:54,916 LAST TIME I WENT TO THE WORLD 2150 01:22:54,916 --> 01:22:55,884 CANCER CONGRESS AT THEIR 2151 01:22:55,884 --> 01:22:57,986 COCKTAIL RECEPTION THEY HAD 2152 01:22:57,986 --> 01:22:59,388 MOCKTAILS, RATHER THAN 2153 01:22:59,388 --> 01:22:59,654 COCKTAILS. 2154 01:22:59,654 --> 01:23:02,224 SO CLEARLY THIS UNDERSTANDING OF 2155 01:23:02,224 --> 01:23:06,294 ALCOHOL AND CANCER IS PERVADING 2156 01:23:06,294 --> 01:23:08,230 PROFESSIONAL CONFERENCES AS 2157 01:23:08,230 --> 01:23:08,430 WELT. 2158 01:23:08,430 --> 01:23:10,465 HEALTH INFORMATION NATIONAL 2159 01:23:10,465 --> 01:23:12,000 TREND SURVEY, PUBLICLY AVAILABLE 2160 01:23:12,000 --> 01:23:13,535 DATASET TO OUR EXTRAMURAL 2161 01:23:13,535 --> 01:23:14,836 COMMUNITY, AND WE ADD NEW ITEMS 2162 01:23:14,836 --> 01:23:16,905 TO IT ALL THE TIME THAT 2163 01:23:16,905 --> 01:23:18,006 ACKNOWLEDGE NEW AREAS, NEW 2164 01:23:18,006 --> 01:23:19,674 PRIORITIES, AND ONE OF THEM IS 2165 01:23:19,674 --> 01:23:20,542 CANNABIS WHICH I'LL TALK ABOUT 2166 01:23:20,542 --> 01:23:21,510 IN A BIT. 2167 01:23:21,510 --> 01:23:28,750 YOU CAN SEE SOME ITEMS, TOPICS 2168 01:23:28,750 --> 01:23:29,951 IN THE MOST RECENT 2169 01:23:29,951 --> 01:23:31,353 ADMINISTRATION. 2170 01:23:31,353 --> 01:23:33,355 CURRENT SURVEY IN THE FIELD, 2171 01:23:33,355 --> 01:23:34,556 MORE INFORMATION ABOUT ATTITUDES 2172 01:23:34,556 --> 01:23:35,323 AND ORIENTATION TOWARDS 2173 01:23:35,323 --> 01:23:35,590 CANNABIS. 2174 01:23:35,590 --> 01:23:39,127 WE'VE BEEN WORKING WITH THE 2175 01:23:39,127 --> 01:23:39,694 FRENCH NATIONAL CANCER 2176 01:23:39,694 --> 01:23:40,896 INSTITUTE, INTERESTED IN SOME 2177 01:23:40,896 --> 01:23:43,432 SAME ISSUES WE ARE, TOBACCO, 2178 01:23:43,432 --> 01:23:44,299 ALCOHOL, CANNABIS, AND WE'RE 2179 01:23:44,299 --> 01:23:45,834 FINDING THAT SOME OF THEIR 2180 01:23:45,834 --> 01:23:46,802 APPROACHES ARE USEFUL WHEN WE 2181 01:23:46,802 --> 01:23:47,736 THINK ABOUT WHAT WE SHOULD BE 2182 01:23:47,736 --> 01:23:50,305 DOING IN THE U.S. 2183 01:23:50,305 --> 01:23:51,606 AND VICE VERSA. 2184 01:23:51,606 --> 01:23:52,974 THEY ARE VERY INTERESTED IN 2185 01:23:52,974 --> 01:23:54,676 CO-MORBIDITIES SUCH AS MENTAL 2186 01:23:54,676 --> 01:23:56,845 HEALTH CONDITIONS, SUBSTANCE USE 2187 01:23:56,845 --> 01:23:57,279 DISORDERS. 2188 01:23:57,279 --> 01:23:58,613 AND THE PROFILE LOOKS DIFFERENT 2189 01:23:58,613 --> 01:23:59,915 IN FRANCE THAN HERE WHICH MEANS 2190 01:23:59,915 --> 01:24:05,921 WE CAN LEARN FROM EACH OTHER. 2191 01:24:05,921 --> 01:24:12,294 YOU MIGHT BE FAMILIAR CAN THE 2192 01:24:12,294 --> 01:24:14,262 SMOKEFREE SITE, WE'VE HAD A 2193 01:24:14,262 --> 01:24:16,765 COUPLE SMALL PROJECTS TO FOCUS 2194 01:24:16,765 --> 01:24:17,866 ON SPECIFIC POPULATIONS, ONE OF 2195 01:24:17,866 --> 01:24:25,173 WHICH JUST CAME OUT LAST YEAR, 2196 01:24:25,173 --> 01:24:26,842 SMOKEFREENATIVE FOCUSING ON 2197 01:24:26,842 --> 01:24:29,010 AMERICAN INDIAN AND ALASKA 2198 01:24:29,010 --> 01:24:30,111 NATIVE. 2199 01:24:30,111 --> 01:24:36,685 AND FINALLY WE HAVE A RECENT 2200 01:24:36,685 --> 01:24:38,653 PROGRAM ANNOUNCEMENT TO THINK 2201 01:24:38,653 --> 01:24:40,489 ABOUT HOW TOBACCO POLICIES HAVE 2202 01:24:40,489 --> 01:24:41,156 DIFFERENTIAL IMPACT ON 2203 01:24:41,156 --> 01:24:41,923 DIFFERENTIAL POPULATIONS THAT 2204 01:24:41,923 --> 01:24:43,625 LED TO A NUMBER OF EXCITING 2205 01:24:43,625 --> 01:24:45,327 PROJECTS, WE BROUGHT P.I.s 2206 01:24:45,327 --> 01:24:46,628 TOGETHER, AND WE GOT THEM TO 2207 01:24:46,628 --> 01:24:48,697 TALK ABOUT THEIR PROJECTS IN A 2208 01:24:48,697 --> 01:24:49,464 RECENT MEETING, THAT'S STARTING 2209 01:24:49,464 --> 01:24:51,032 TO MAKE US THINK ABOUT HOW WE 2210 01:24:51,032 --> 01:24:52,534 SHOULD BE DOING THIS WORK NOT 2211 01:24:52,534 --> 01:24:54,736 JUST IN TOBACCO SPACE BUT IN 2212 01:24:54,736 --> 01:24:56,705 ALCOHOL AND CANNABIS AS WELL. 2213 01:24:56,705 --> 01:24:58,907 YOU CAN IMAGINE THAT MANY OF THE 2214 01:24:58,907 --> 01:25:00,542 NEW POLICIES REGARDING CANNABIS 2215 01:25:00,542 --> 01:25:04,179 MIGHT AFFECT TOBACCO USE AND 2216 01:25:04,179 --> 01:25:05,046 VICE VERSA, YOU CAN THROW 2217 01:25:05,046 --> 01:25:07,148 ALCOHOL IN THE MIX AS WELL, 2218 01:25:07,148 --> 01:25:08,550 REALLY CAPTURING OUR ATTENTION. 2219 01:25:08,550 --> 01:25:10,752 HERE ARE FUNDING OPPORTUNITIES 2220 01:25:10,752 --> 01:25:12,387 THAT WE PUT OUT RECENTLY, AND 2221 01:25:12,387 --> 01:25:14,356 THIS IS NOT NECESSARILY TO SAY, 2222 01:25:14,356 --> 01:25:15,891 HEY, APPLY, ALTHOUGH I HOPE YOU 2223 01:25:15,891 --> 01:25:18,093 DO AND YOUR COLLEAGUES DO BUT TO 2224 01:25:18,093 --> 01:25:20,395 IDENTIFY SOME OF OUR PRIORITIES. 2225 01:25:20,395 --> 01:25:22,998 SECOND ON THE LIST POPULATION 2226 01:25:22,998 --> 01:25:24,065 APPROACHES TO REDUCING 2227 01:25:24,065 --> 01:25:25,200 ALCOHOL-RELATED CANCER RISK, 2228 01:25:25,200 --> 01:25:27,068 THIS IS A WONDERFUL 2229 01:25:27,068 --> 01:25:27,936 COLLABORATION WITH NIAAA AND THE 2230 01:25:27,936 --> 01:25:30,472 IDEA IS TO BE ABLE TO PULL IN 2231 01:25:30,472 --> 01:25:31,907 APPLICATIONS THAT REALLY ADDRESS 2232 01:25:31,907 --> 01:25:33,208 THE PROBLEM GEORGE ALLUDED TO 2233 01:25:33,208 --> 01:25:34,943 WHICH IS THAT THE POPULATION IS 2234 01:25:34,943 --> 01:25:36,611 JUST NOT AWARE OF THIS LINK 2235 01:25:36,611 --> 01:25:38,680 BETWEEN ALCOHOL AND CANCER. 2236 01:25:38,680 --> 01:25:39,748 OBVIOUSLY POLICY APPROACHES 2237 01:25:39,748 --> 01:25:42,284 WOULD BE ONE APPROACH, BUT WE 2238 01:25:42,284 --> 01:25:42,784 ALSO NEED COMMUNICATION 2239 01:25:42,784 --> 01:25:44,386 APPROACHES, AND SO WE'RE HOPING 2240 01:25:44,386 --> 01:25:47,188 WE GET SOME APPLICATIONS THAT 2241 01:25:47,188 --> 01:25:47,756 ADDRESS THAT ISSUE. 2242 01:25:47,756 --> 01:25:53,228 FURTHER DOWN ON THE SLIDE YOU'LL 2243 01:25:53,228 --> 01:25:56,064 SEE RECENTLY EXPIRED FUNDING 2244 01:25:56,064 --> 01:25:57,265 OPPORTUNITIES. 2245 01:25:57,265 --> 01:25:59,034 FIRST ON TOP ADVANCING 2246 01:25:59,034 --> 01:26:00,235 ADOLESCENT TOBACCO CESSATION 2247 01:26:00,235 --> 01:26:01,870 INTERVENTION RESEARCH, IS REALLY 2248 01:26:01,870 --> 01:26:02,037 KEY. 2249 01:26:02,037 --> 01:26:03,171 I THINK YOU'LL PROBABLY GLEAN 2250 01:26:03,171 --> 01:26:04,739 THIS FROM ALL OF THE WORK THAT 2251 01:26:04,739 --> 01:26:06,908 NORA HAS DONE AND OTHERS AT 2252 01:26:06,908 --> 01:26:08,443 NIDA, ADOLESCENTS ARE JUST NOT 2253 01:26:08,443 --> 01:26:09,644 THE SAME AS ADULTS. 2254 01:26:09,644 --> 01:26:11,179 THEY ARE ALIENS, RIGHT? 2255 01:26:11,179 --> 01:26:12,981 THEIR BRAINS ARE IN A DIFFERENT 2256 01:26:12,981 --> 01:26:14,649 STATE, BRAINS STILL DEVELOPING. 2257 01:26:14,649 --> 01:26:16,217 WE KNOW RESEARCH BEHIND THAT. 2258 01:26:16,217 --> 01:26:19,187 BUT OF COURSE THE IMPLICATION 2259 01:26:19,187 --> 01:26:20,355 THEY ARE NOT GOING TO BE 2260 01:26:20,355 --> 01:26:22,657 RESPONSIVE TO THE SAME 2261 01:26:22,657 --> 01:26:24,192 APPROACHES WITH ADULTS TO STOP 2262 01:26:24,192 --> 01:26:24,859 USING TOBACCO. 2263 01:26:24,859 --> 01:26:26,494 AND THEY ARE NOT SMOKING 2264 01:26:26,494 --> 01:26:28,496 CIGARETTES MUCH ANYMORE EITHER, 2265 01:26:28,496 --> 01:26:29,331 AS NORA ALLUDED TO. 2266 01:26:29,331 --> 01:26:31,766 MOST OF THE DATA POINT TOWARDS 2267 01:26:31,766 --> 01:26:33,501 VAPING AND OTHER PRODUCTS. 2268 01:26:33,501 --> 01:26:35,704 WE HAVE A VERY SMALL LITERATURE 2269 01:26:35,704 --> 01:26:37,005 THAT ADDRESSES CESSATION IN THIS 2270 01:26:37,005 --> 01:26:38,340 POPULATION WHEN IT COMES TO 2271 01:26:38,340 --> 01:26:41,042 VAPING, SO WE PUT OUT AN RFA IN 2272 01:26:41,042 --> 01:26:42,811 THIS AREA, GOT LOTS OF GREAT 2273 01:26:42,811 --> 01:26:43,645 APPLICATIONS, WE'RE WORKING 2274 01:26:43,645 --> 01:26:45,213 THROUGH THEM RIGHT NOW TO DECIDE 2275 01:26:45,213 --> 01:26:45,981 WHAT TO FUND. 2276 01:26:45,981 --> 01:26:48,183 I THINK THAT'S GOING TO ADVANCE 2277 01:26:48,183 --> 01:26:50,251 THIS AREA IN WAYS THAT ARE VERY 2278 01:26:50,251 --> 01:26:50,518 IMPORTANT. 2279 01:26:50,518 --> 01:26:52,887 SECOND ONE DOWN ON THE RECENTLY 2280 01:26:52,887 --> 01:26:56,725 EXPIRED LIST, PUBLIC HEALTH 2281 01:26:56,725 --> 01:26:57,359 COMMUNICATION MESSAGING ABOUT 2282 01:26:57,359 --> 01:26:58,560 THE CONTINUUM OF RISK FOR 2283 01:26:58,560 --> 01:26:59,494 TOBACCO PRODUCTS, A LIGHTNING 2284 01:26:59,494 --> 01:27:02,197 BOLT ISSUE. 2285 01:27:02,197 --> 01:27:03,465 THIS IS REALLY GALVANIZING THE 2286 01:27:03,465 --> 01:27:04,599 PUBLIC HEALTH COMMUNITY, THE 2287 01:27:04,599 --> 01:27:07,235 QUESTION OF CONTINUUM OF RISK, 2288 01:27:07,235 --> 01:27:09,204 IS ALL TOBACCO BAD, ALL NICOTINE 2289 01:27:09,204 --> 01:27:11,640 BAD OR SHOULD WE THINK OF 2290 01:27:11,640 --> 01:27:13,375 CONTINUUM OF RISK WHERE 2291 01:27:13,375 --> 01:27:17,979 COMBUSTIBLE CIGARETTES ARE BAD 2292 01:27:17,979 --> 01:27:19,280 AND OTHER PRODUCTS ARE ALSO BAD 2293 01:27:19,280 --> 01:27:20,682 BUT LESS BAD. 2294 01:27:20,682 --> 01:27:21,783 THE PUBLIC HEALTH COMMUNITY HAS 2295 01:27:21,783 --> 01:27:24,886 BEEN ENGAGED IN WAYS THAT CAUSED 2296 01:27:24,886 --> 01:27:25,854 FIST FIGHTS AT CONFERENCES, THIS 2297 01:27:25,854 --> 01:27:29,024 IS REALLY A HOT ISSUE. 2298 01:27:29,024 --> 01:27:29,491 AND SO FOOD AND DRUG 2299 01:27:29,491 --> 01:27:30,525 ADMINISTRATION, CENTER FOR 2300 01:27:30,525 --> 01:27:31,660 TOBACCO PRODUCTS, IS NOW ENGAGED 2301 01:27:31,660 --> 01:27:34,062 IN TRYING TO UNDERSTAND HOW WE 2302 01:27:34,062 --> 01:27:35,263 SHOULD COMMUNICATE ABOUT THE 2303 01:27:35,263 --> 01:27:36,898 CONTINUUM OF RISK TO THE 2304 01:27:36,898 --> 01:27:38,433 AMERICAN POPULATION, IN WAYS 2305 01:27:38,433 --> 01:27:40,301 THAT DON'T GET ADOLESCENTS TO 2306 01:27:40,301 --> 01:27:43,705 START USING THESE PRODUCTS BUT 2307 01:27:43,705 --> 01:27:47,842 POTENTIALLY POSITION THE 2308 01:27:47,842 --> 01:27:49,477 PRODUCTS AS CESSATION METHOD FOR 2309 01:27:49,477 --> 01:27:54,849 ADULTS, A TRICKY NEED TOLL -- 2310 01:27:54,849 --> 01:27:55,650 NEEDLE TO THREAD. 2311 01:27:55,650 --> 01:27:58,453 FDA PROVIDES FUNDING BUT WE DO 2312 01:27:58,453 --> 01:27:59,988 THE PEER REVIEW AND MANAGEMENT 2313 01:27:59,988 --> 01:28:01,623 OF GRANTS THROUGH OFFICE OF 2314 01:28:01,623 --> 01:28:04,292 DISEASE PREVENTION AND MANY 2315 01:28:04,292 --> 01:28:05,660 OTHER INSTITUTES AROUND NIH. 2316 01:28:05,660 --> 01:28:09,431 SO, HERE I WANT TO TELL YOU 2317 01:28:09,431 --> 01:28:10,665 ABOUT OUR HALLWAY CONVERSATIONS, 2318 01:28:10,665 --> 01:28:12,801 THINGS THAT ENGAGE US ON A DAILY 2319 01:28:12,801 --> 01:28:14,235 BASIS AND THINK ABOUT WHAT'S 2320 01:28:14,235 --> 01:28:14,769 COMING NEXT. 2321 01:28:14,769 --> 01:28:16,204 I'LL START WITH TOBACCO. 2322 01:28:16,204 --> 01:28:18,606 YOU ARE FAMILIAR WITH THE FACT 2323 01:28:18,606 --> 01:28:21,443 THAT FDA PUT FORWARD A PRODUCT 2324 01:28:21,443 --> 01:28:22,777 STANDARD FOR MENTHOL ESSENTIALLY 2325 01:28:22,777 --> 01:28:28,249 BANNING MENTHOL, A MAJOR GAME 2326 01:28:28,249 --> 01:28:30,552 CHANGER WITH REGARD TO TOBACCO 2327 01:28:30,552 --> 01:28:32,187 USE BECAUSE MENTHOL HAS BEEN 2328 01:28:32,187 --> 01:28:36,791 SHOWN TO IMPEDE ABILITY TO STOP 2329 01:28:36,791 --> 01:28:37,425 SMOKING. 2330 01:28:37,425 --> 01:28:38,893 IT SOFTENS THE REACTION TO 2331 01:28:38,893 --> 01:28:39,127 TOBACCO. 2332 01:28:39,127 --> 01:28:41,463 AND AS A RESULT OF THAT, IT 2333 01:28:41,463 --> 01:28:45,734 MAKES IT MORE DIFFICULT TO QUIT 2334 01:28:45,734 --> 01:28:46,401 AND MENTHOLATED CIGARETTES TEND 2335 01:28:46,401 --> 01:28:48,236 TO BE USED BY SOME POPULATIONS 2336 01:28:48,236 --> 01:28:49,904 MORE THAN OTHERS, PARTICULARLY 2337 01:28:49,904 --> 01:28:50,538 AFRICAN AMERICAN POPULATIONS, 2338 01:28:50,538 --> 01:28:53,842 THAT'S WHY THIS ISSUE IS VERY 2339 01:28:53,842 --> 01:28:55,143 IMPORTANT AND VERY HIGHLY 2340 01:28:55,143 --> 01:28:56,411 CONTESTED ISSUE. 2341 01:28:56,411 --> 01:28:57,746 AND YOU CAN TELL FROM HEADLINES 2342 01:28:57,746 --> 01:29:03,818 HERE IT'S BEEN AN ISSUE THAT HAS 2343 01:29:03,818 --> 01:29:05,553 BEEN FRAUGHT. 2344 01:29:05,553 --> 01:29:07,155 FDA PUSHED THIS FORWARD TO OMB 2345 01:29:07,155 --> 01:29:08,089 AND THE WHITE HOUSE, THERE'S 2346 01:29:08,089 --> 01:29:10,058 BEEN A DELAY IN TRYING TO 2347 01:29:10,058 --> 01:29:11,593 INSTITUTE IT BECAUSE OF MANY 2348 01:29:11,593 --> 01:29:12,460 SOCIAL AND CULTURAL ISSUES THAT 2349 01:29:12,460 --> 01:29:13,862 GO ALONG WITH THIS. 2350 01:29:13,862 --> 01:29:16,397 I EXPECT AT SOME POINT IT WILL 2351 01:29:16,397 --> 01:29:16,631 HAPPEN. 2352 01:29:16,631 --> 01:29:18,566 IT'S JUST INDISPUTABLE THAT IF 2353 01:29:18,566 --> 01:29:21,102 WE BAN MENTHOL, TOBACCO USE WILL 2354 01:29:21,102 --> 01:29:22,937 GO DOWN PARTICULARLY COMBUSTIBLE 2355 01:29:22,937 --> 01:29:24,272 CIGARETTES, AND SO WHETHER IT 2356 01:29:24,272 --> 01:29:25,507 HAPPENS, WHEN IT HAPPENS, I'M 2357 01:29:25,507 --> 01:29:27,575 PUTTING THAT OFF FOR NOW BUT I 2358 01:29:27,575 --> 01:29:28,877 THINK THE EVIDENCE IS CLEAR. 2359 01:29:28,877 --> 01:29:30,512 WE'RE NOT FOCUSING ON TRYING TO 2360 01:29:30,512 --> 01:29:32,213 COLLECT MORE EVIDENCE FOR THAT. 2361 01:29:32,213 --> 01:29:34,783 NOW WHERE THE FOCUS IS, GETTING 2362 01:29:34,783 --> 01:29:36,317 EVIDENCE FOR KINDS OF PROGRAMS 2363 01:29:36,317 --> 01:29:40,155 TO HELP PEOPLE WHO USE 2364 01:29:40,155 --> 01:29:41,222 MENTHOLATED CIGARETTES TO QUIT. 2365 01:29:41,222 --> 01:29:42,891 ALSO WANT TO MENTION SOMETHING 2366 01:29:42,891 --> 01:29:44,793 WE'VE BEEN INVOLVED IN OVER THE 2367 01:29:44,793 --> 01:29:48,997 YEARS, WHICH PROBABLY YOU'VE 2368 01:29:48,997 --> 01:29:51,666 SEEN IF YOU'VE WALKED INTO CVS 2369 01:29:51,666 --> 01:29:52,967 OR WALGREEN'S AND OTHER PLACES 2370 01:29:52,967 --> 01:29:54,102 THAT SELL TOBACCO. 2371 01:29:54,102 --> 01:29:56,805 THIS GOES BACK 20 YEARS, 2372 01:29:56,805 --> 01:29:57,338 DEPARTMENT OF JUSTICE AND 2373 01:29:57,338 --> 01:29:58,439 DEPARTMENT OF HEALTH AND HUMAN 2374 01:29:58,439 --> 01:30:00,408 SERVICES, THEY ANNOUNCED A COURT 2375 01:30:00,408 --> 01:30:02,710 OUT THAT RESOLVED -- WELL, THIS 2376 01:30:02,710 --> 01:30:04,579 IS 2022, THIS RESOLUTION OF 2377 01:30:04,579 --> 01:30:05,680 CIVIL RECOLLECT TEARING LAWSUIT 2378 01:30:05,680 --> 01:30:06,981 FIRST BROUGHT AGAINST THE 2379 01:30:06,981 --> 01:30:07,749 TOBACCO COMPANIES. 2380 01:30:07,749 --> 01:30:09,517 AND WHAT THAT HAS LED TO, 2381 01:30:09,517 --> 01:30:15,323 THERE'S A LOT THAT HAPPENED IN 2382 01:30:15,323 --> 01:30:18,493 BETWEEN, THE SIGNS NOW AT POINT 2383 01:30:18,493 --> 01:30:20,562 OF SALE ABOUT IMPACT OF TOBACCO. 2384 01:30:20,562 --> 01:30:22,730 OUR STAFF HELPED DEVELOP THESE 2385 01:30:22,730 --> 01:30:26,601 MESSAGES AND COLLECT SOME DATA 2386 01:30:26,601 --> 01:30:28,336 SUPPORTING THEIR EFFICACY. 2387 01:30:28,336 --> 01:30:29,604 TURNING NOW TO CANNABIS, SO 2388 01:30:29,604 --> 01:30:31,406 WE'RE PLAYING IN THE CANNABIS 2389 01:30:31,406 --> 01:30:33,341 SPACE IN TWO WAYS. 2390 01:30:33,341 --> 01:30:34,576 OBVIOUSLY WE'RE INTERESTED IN 2391 01:30:34,576 --> 01:30:36,544 UPTAKE OF CANNABIS AND USE OF 2392 01:30:36,544 --> 01:30:37,745 CANNABIS AT THE POPULATION LEVEL 2393 01:30:37,745 --> 01:30:39,714 AND WE'RE CONCERNED ABOUT THE 2394 01:30:39,714 --> 01:30:42,317 EFFECTS OF CANNABIS SMOKE IN THE 2395 01:30:42,317 --> 01:30:43,418 SAME WAY WE'RE CONCERNED ABOUT 2396 01:30:43,418 --> 01:30:45,286 TOBACCO SMOKE AND EFFECTS ON 2397 01:30:45,286 --> 01:30:46,054 LUNG DISEASE, POTENTIALLY 2398 01:30:46,054 --> 01:30:46,487 CANCER. 2399 01:30:46,487 --> 01:30:47,255 THAT'S ONE PIECE. 2400 01:30:47,255 --> 01:30:49,424 THEN WE ALSO ARE FOCUSED ON 2401 01:30:49,424 --> 01:30:51,826 CANNABIS IN TERMS OF PAIN 2402 01:30:51,826 --> 01:30:52,861 MANAGEMENT, FOR CANCER PATIENTS, 2403 01:30:52,861 --> 01:30:53,928 CANCER SURVIVORS. 2404 01:30:53,928 --> 01:30:56,664 AND SO WE'VE GOT A TRANSNCI 2405 01:30:56,664 --> 01:30:58,533 CANNABIS AND CANCER RESEARCH 2406 01:30:58,533 --> 01:31:00,602 INTEREST GROUP FOCUSING ON ON 2407 01:31:00,602 --> 01:31:01,903 BOTH PIECES AND EVERYTHING IN 2408 01:31:01,903 --> 01:31:02,904 BETWEEN, SO MUCH TO DO HERE, SO 2409 01:31:02,904 --> 01:31:03,972 MANY QUESTIONS THAT NEED TO BE 2410 01:31:03,972 --> 01:31:05,506 ASKED, SO MANY ISSUES THAT NEED 2411 01:31:05,506 --> 01:31:06,374 TO BE ADDRESSED. 2412 01:31:06,374 --> 01:31:08,676 AND WE HAVE A BIT OF PLAYBOOK 2413 01:31:08,676 --> 01:31:10,511 WITH REGARD TO TOBACCO BUT THAT 2414 01:31:10,511 --> 01:31:11,980 PLAYBOOK DOESN'T SEEM TO WORK 2415 01:31:11,980 --> 01:31:13,381 QUITE AS WELL FOR CANNABIS. 2416 01:31:13,381 --> 01:31:14,816 THAT'S TRUE FOR ALCOHOL AS WELL. 2417 01:31:14,816 --> 01:31:18,987 WE NEED TO DEVELOP A NEW PLAY 2418 01:31:18,987 --> 01:31:27,328 BOOKER THAT LEVER AGES LESSONED 2419 01:31:27,328 --> 01:31:28,062 LEARNED BUT DOESN'T THINK 2420 01:31:28,062 --> 01:31:30,598 EVERYTHING IS GOING TO 2421 01:31:30,598 --> 01:31:31,232 TRANSLATE. 2422 01:31:31,232 --> 01:31:32,233 A NATIONAL ACADEMIES RECORD IN 2423 01:31:32,233 --> 01:31:36,070 2018, NOW A NEW ONE IN 2024, AN 2424 01:31:36,070 --> 01:31:37,705 UPDATE, AND WE'VE CONTRIBUTED, 2425 01:31:37,705 --> 01:31:39,774 FOCUSED ON LANDSCAPE VIEW OF 2426 01:31:39,774 --> 01:31:41,843 EFFECTS OF CANNABIS AND WHAT 2427 01:31:41,843 --> 01:31:42,844 SOME POLICY IMPLICATIONS MIGHT 2428 01:31:42,844 --> 01:31:46,147 LOOK LIKE, SOMETHING TO LOOK OUT 2429 01:31:46,147 --> 01:31:46,614 FOR. 2430 01:31:46,614 --> 01:31:47,749 MOVING TO ALCOHOL AND CANCER 2431 01:31:47,749 --> 01:31:49,417 YOU'VE HEARD ME TALK AT THIS 2432 01:31:49,417 --> 01:31:59,961 MEETING AND GEORGE AS WELL TALK 2433 01:32:00,428 --> 01:32:02,864 ABOUT THIS LINK, WORKSHOPS AND 2434 01:32:02,864 --> 01:32:04,399 SURVEYS, PUBLISHED THOSE DATA, 2435 01:32:04,399 --> 01:32:06,501 THANK YOU, GEORGE, FOR CITING 2436 01:32:06,501 --> 01:32:07,568 SOME DATA IN A SLIDE. 2437 01:32:07,568 --> 01:32:09,771 I WANT TO POINT OUT NEW THINGS 2438 01:32:09,771 --> 01:32:10,538 THAT WE'RE FOCUSING ON. 2439 01:32:10,538 --> 01:32:15,576 FIRST OF ALL WE HAVE THIS NEW 2440 01:32:15,576 --> 01:32:17,445 PROJECT CALLED OPTICS, PROMOTING 2441 01:32:17,445 --> 01:32:18,880 HEALTHY LIFESTYLES TO OPTIMIZE 2442 01:32:18,880 --> 01:32:19,981 CANCER SURVIVORSHIP. 2443 01:32:19,981 --> 01:32:22,717 I'M NOT THE ACRONYM PERSON IN MY 2444 01:32:22,717 --> 01:32:23,918 PROGRAM, I'M SURROUNDED BY 2445 01:32:23,918 --> 01:32:24,686 COLLEAGUES MORE CREATIVE THAT 2446 01:32:24,686 --> 01:32:27,188 CAME UP WITH THIS ONE. 2447 01:32:27,188 --> 01:32:28,623 WE'RE LOOKING AT CANCER CENTERS 2448 01:32:28,623 --> 01:32:31,259 TO SEE HOW CANCER CENTERS ARE 2449 01:32:31,259 --> 01:32:32,794 ADDRESSING BEHAVIORAL RISK 2450 01:32:32,794 --> 01:32:34,629 FACTORS FOR CANCER. 2451 01:32:34,629 --> 01:32:35,964 YOU WOULD IMAGINE, FOR EXAMPLE, 2452 01:32:35,964 --> 01:32:38,566 THAT CANCER CENTERS WOULD HAVE 2453 01:32:38,566 --> 01:32:39,200 WELL-DEVELOPED TOBACCO CESSATION 2454 01:32:39,200 --> 01:32:40,902 PROGRAMS AS PART OF THEIR 2455 01:32:40,902 --> 01:32:41,469 CLINICAL PRACTICE. 2456 01:32:41,469 --> 01:32:43,037 TURNS OUT UP UNTIL RECENTLY THAT 2457 01:32:43,037 --> 01:32:44,806 WAS NOT TRUE. 2458 01:32:44,806 --> 01:32:46,240 WE HAVE NOW FUNDED 52 CANCER 2459 01:32:46,240 --> 01:32:48,409 CENTERS TO BUILD UP TOBACCO 2460 01:32:48,409 --> 01:32:50,211 CESSATION PROGRAMS WITHIN THEIR 2461 01:32:50,211 --> 01:32:51,479 CANCER CENTERS. 2462 01:32:51,479 --> 01:32:54,649 THAT WAS A TERMINAL GRANT SO 2463 01:32:54,649 --> 01:32:56,184 WE'RE HOPING THERE'S SOME 2464 01:32:56,184 --> 01:32:57,051 SUSTAINABILITY THERE BUT THINK 2465 01:32:57,051 --> 01:32:59,354 IT'S IMPORTANT TO MAKE THOSE 2466 01:32:59,354 --> 01:32:59,654 INVESTMENTS. 2467 01:32:59,654 --> 01:33:03,958 NOW WE'RE WORKING WITH A 2468 01:33:03,958 --> 01:33:04,592 COLLEAGUE AT MEMORIAL 2469 01:33:04,592 --> 01:33:05,827 SLOAN-KETTERING, JENNIFER HAY, 2470 01:33:05,827 --> 01:33:07,328 TO UNDERSTAND HOW ALCOHOL IS 2471 01:33:07,328 --> 01:33:08,763 BEING ADDRESSED IN CANCER 2472 01:33:08,763 --> 01:33:09,030 SETTINGS. 2473 01:33:09,030 --> 01:33:10,965 WE WERE JOKING BEFORE THE 2474 01:33:10,965 --> 01:33:12,700 MEETING THIS MORNING THAT 2475 01:33:12,700 --> 01:33:15,003 ALCOHOL IS OFTEN RECOMMENDED TO 2476 01:33:15,003 --> 01:33:15,636 CANCER SURVIVORS, CANCER 2477 01:33:15,636 --> 01:33:18,306 PATIENTS, AS A WAY TO RELAX, A 2478 01:33:18,306 --> 01:33:22,543 WAY TO GET AWAY THE DIAGNOSIS 2479 01:33:22,543 --> 01:33:25,079 AND DIFFICULTY OF MAKING HARD 2480 01:33:25,079 --> 01:33:26,481 DECISIONS, WE SEE PINK WASHING 2481 01:33:26,481 --> 01:33:27,915 HAPPENING NOW, WHERE THE 2482 01:33:27,915 --> 01:33:29,317 BEVERAGE INDUSTRY WILL TAKE 2483 01:33:29,317 --> 01:33:31,419 BEVERAGES AND MAKE THEM PINK 2484 01:33:31,419 --> 01:33:33,187 LIKE MIKE'S HARD PINK LEMONADE, 2485 01:33:33,187 --> 01:33:33,621 RIGHT? 2486 01:33:33,621 --> 01:33:35,390 AND PUT THE PINK RIBBON ON THEIR 2487 01:33:35,390 --> 01:33:36,924 PRODUCT AND SAY THEY ARE GOING 2488 01:33:36,924 --> 01:33:39,794 TO DONATE MONEY TO BREAST CANCER 2489 01:33:39,794 --> 01:33:40,061 RESEARCH. 2490 01:33:40,061 --> 01:33:41,195 THAT SOUNDS GREAT. 2491 01:33:41,195 --> 01:33:43,464 PROBLEM, YOU KNOW, THAT 2492 01:33:43,464 --> 01:33:44,198 PARTICULAR PRODUCT INCREASES 2493 01:33:44,198 --> 01:33:46,100 RISK OF BREAST CANCER, THERE'S 2494 01:33:46,100 --> 01:33:46,968 AN ISSUE THERE. 2495 01:33:46,968 --> 01:33:49,737 AND SO WE'RE INTERESTED IN 2496 01:33:49,737 --> 01:33:50,705 UNDERSTANDING HOW CANCER 2497 01:33:50,705 --> 01:33:51,706 SURVIVORS, CANCER PATIENTS, ARE 2498 01:33:51,706 --> 01:33:54,342 BEING INFORMED ABOUT THIS LINK 2499 01:33:54,342 --> 01:33:55,943 BETWEEN ALCOHOL AND CANCER. 2500 01:33:55,943 --> 01:33:57,211 I'LL ALSO MENTION THAT THERE ARE 2501 01:33:57,211 --> 01:33:59,147 TWO REPORTS THAT ARE BEING 2502 01:33:59,147 --> 01:34:01,416 DEVELOPED NOW ON THE EFFECTS OF 2503 01:34:01,416 --> 01:34:03,284 ALCOHOL AND NOT JUST ALCOHOL AND 2504 01:34:03,284 --> 01:34:05,353 CANCER BUT OTHER HEALTH ISSUES 2505 01:34:05,353 --> 01:34:06,354 AS WELL. 2506 01:34:06,354 --> 01:34:08,156 THERE'S NOW A CONGRESSIONALLY 2507 01:34:08,156 --> 01:34:09,424 MANDATED NATIONAL ACADEMIES 2508 01:34:09,424 --> 01:34:11,159 REVIEW OF EVIDENCE ON ALCOHOL 2509 01:34:11,159 --> 01:34:13,528 AND HEALTH WHICH WILL INFORM THE 2510 01:34:13,528 --> 01:34:14,395 NEXT SET OF DIETARY GUIDELINES 2511 01:34:14,395 --> 01:34:15,430 IN THE U.S. 2512 01:34:15,430 --> 01:34:17,732 BOY, THIS IS GOING TO BE AN 2513 01:34:17,732 --> 01:34:18,833 INTERESTING ONE BECAUSE ALCOHOL 2514 01:34:18,833 --> 01:34:20,068 IS OFTEN PUSHED A BIT TO THE 2515 01:34:20,068 --> 01:34:22,203 SIDE WITH THE U.S. DIETARY 2516 01:34:22,203 --> 01:34:25,473 GUIDELINES, MORE OF A FOCUS ON 2517 01:34:25,473 --> 01:34:28,009 THE PLATE THAN MAKING SURE 2518 01:34:28,009 --> 01:34:30,178 APPORTIONMENT OF FRUITS AND 2519 01:34:30,178 --> 01:34:32,380 MEATS AND VEGETABLES IS JUST 2520 01:34:32,380 --> 01:34:32,613 RIGHT. 2521 01:34:32,613 --> 01:34:35,216 ALCOHOL WILL BIG A BIG ROLE IN 2522 01:34:35,216 --> 01:34:37,518 THE NEXT GUIDELINES. 2523 01:34:37,518 --> 01:34:38,653 LOOK NORTH TO CANADA WHO CHANGED 2524 01:34:38,653 --> 01:34:40,054 TO SAY THERE'S NO AMOUNT OF 2525 01:34:40,054 --> 01:34:42,023 ALCOHOL THAT'S SAFE AND THAT 2526 01:34:42,023 --> 01:34:43,491 MODERATE CONSUMPTION IS NOW ONE 2527 01:34:43,491 --> 01:34:45,293 OR TWO DRINKS A WEEK AS OPPOSED 2528 01:34:45,293 --> 01:34:46,727 TO A DAY WHAT THEY HAVE BEEN 2529 01:34:46,727 --> 01:34:48,196 HERE IN THIS COUNTRY. 2530 01:34:48,196 --> 01:34:49,997 SORRY, YOU KNOW, BAD NEWS, AS 2531 01:34:49,997 --> 01:34:51,732 GEORGE SAID, NOT SOMETHING WE 2532 01:34:51,732 --> 01:34:53,935 WANT TO HEAR BUT IMPORTANT TO 2533 01:34:53,935 --> 01:34:55,036 FOLLOW THE SCIENCE. 2534 01:34:55,036 --> 01:34:56,003 FINALLY I'LL SAY WE'VE BEEN 2535 01:34:56,003 --> 01:34:57,538 INVOLVED IN SOME EFFORTS TO 2536 01:34:57,538 --> 01:34:58,439 ADDRESS ALCOHOL LABELING. 2537 01:34:58,439 --> 01:35:01,709 SO YOU MAY OR MAY NOT BE AWARE 2538 01:35:01,709 --> 01:35:02,243 THAT SEVERAL PROFESSIONAL 2539 01:35:02,243 --> 01:35:03,578 ASSOCIATIONS, MAYBE SOME YOU'RE 2540 01:35:03,578 --> 01:35:06,547 PART OF, INCLUDING AMERICAN 2541 01:35:06,547 --> 01:35:07,615 PUBLIC HEALTH ASSOCIATION, 2542 01:35:07,615 --> 01:35:08,716 PETITIONED DEPARTMENT OF 2543 01:35:08,716 --> 01:35:10,451 TREASURY TO CHANGE LABELS YOU 2544 01:35:10,451 --> 01:35:13,654 SEE ON ALCOHOLIC BEVERAGES THAT 2545 01:35:13,654 --> 01:35:15,289 INDICATE WHAT THE HEALTH 2546 01:35:15,289 --> 01:35:16,824 PROBLEMS ARE WITH ALCOHOL USE. 2547 01:35:16,824 --> 01:35:20,094 YOU KNOW, IF YOU TAKE A LOOK, 2548 01:35:20,094 --> 01:35:21,329 PROBABLY HAVEN'T LOOKED LATELY, 2549 01:35:21,329 --> 01:35:23,030 THEY ARE PRETTY VAGUE. 2550 01:35:23,030 --> 01:35:25,032 THEY DO MAKE SOME MENTION OF 2551 01:35:25,032 --> 01:35:26,767 PREGNANCY AND DWI AND OTHER 2552 01:35:26,767 --> 01:35:28,302 HEALTH EFFECTS, WHATEVER THAT 2553 01:35:28,302 --> 01:35:29,303 MEANS, RIGHT? 2554 01:35:29,303 --> 01:35:31,472 AND SO THAT PETITION WAS 2555 01:35:31,472 --> 01:35:32,573 SPECIFICALLY TARGETED TOWARDS 2556 01:35:32,573 --> 01:35:33,341 PUTTING SOMETHING ABOUT CANCER 2557 01:35:33,341 --> 01:35:35,076 ON THE LABELS BUT WHAT'S THE 2558 01:35:35,076 --> 01:35:36,711 EVIDENCE FOR DOING THAT, RIGHT? 2559 01:35:36,711 --> 01:35:38,713 SO, THE DEPARTMENT OF THE 2560 01:35:38,713 --> 01:35:40,448 TREASURY HAS THE ALCOHOL AND 2561 01:35:40,448 --> 01:35:42,216 TOBACCO TAX AND TRADE BUREAU 2562 01:35:42,216 --> 01:35:43,618 UNDER ITS AUSPICES, AND THAT'S 2563 01:35:43,618 --> 01:35:45,253 THE GROUP THAT ACTUALLY OVERSEES 2564 01:35:45,253 --> 01:35:47,355 THOSE LABELS WHICH IS A 2565 01:35:47,355 --> 01:35:49,223 DIFFERENT STORY THAN FDA 2566 01:35:49,223 --> 01:35:51,726 OVERSEEING LABELING ON TOBACCO, 2567 01:35:51,726 --> 01:35:53,261 COMPLETELY DIFFERENT SETUP. 2568 01:35:53,261 --> 01:35:54,996 AND THE TREASURELY DEPARTMENT, 2569 01:35:54,996 --> 01:35:56,097 THEY DON'T HAVE BEHAVIORAL 2570 01:35:56,097 --> 01:35:57,198 SCIENCE EXPERTS NECESSARILY WHO 2571 01:35:57,198 --> 01:35:58,132 CAN ADDRESS THIS QUESTION SO 2572 01:35:58,132 --> 01:35:59,267 THEY WENT TO THE SURGEON 2573 01:35:59,267 --> 01:36:00,902 GENERAL'S OFFICE WHO CAME TO US 2574 01:36:00,902 --> 01:36:02,236 AND TO OTHER INSTITUTES AND SAID 2575 01:36:02,236 --> 01:36:03,437 WHAT DO WE DO HERE? 2576 01:36:03,437 --> 01:36:05,306 AND SO WE'VE BEEN TALKING ABOUT 2577 01:36:05,306 --> 01:36:07,275 TRYING TO HELP THEM WITH THAT. 2578 01:36:07,275 --> 01:36:08,743 I'M NOT SURE WHAT THE OUTCOME 2579 01:36:08,743 --> 01:36:12,013 WILL BE BUT JUST KNOW THAT KIND 2580 01:36:12,013 --> 01:36:14,081 OF WORK IS HAPPENING. 2581 01:36:14,081 --> 01:36:16,017 SO, THESE DATA WON'T BE ANY 2582 01:36:16,017 --> 01:36:18,886 SURPRISE, DATA ON THE RIGHT ARE 2583 01:36:18,886 --> 01:36:20,288 CONSISTENT WITH WHAT YOU HEARD 2584 01:36:20,288 --> 01:36:22,156 IN THE PAST, ALCOHOL IS RELATED 2585 01:36:22,156 --> 01:36:23,491 TO MANY DIFFERENT CANCER TYPES, 2586 01:36:23,491 --> 01:36:25,092 BUT I DO WANT TO HIGHLIGHT 2587 01:36:25,092 --> 01:36:26,561 WHAT'S ON THE LEFT OF THE SLIDE, 2588 01:36:26,561 --> 01:36:28,196 NOW WE'RE STARTING TO ASK 2589 01:36:28,196 --> 01:36:29,630 ANOTHER QUESTION, AND IT'S A 2590 01:36:29,630 --> 01:36:30,598 DIFFERENT QUESTION, WHICH IS 2591 01:36:30,598 --> 01:36:32,567 WHAT HAPPENS WHEN YOU STOP 2592 01:36:32,567 --> 01:36:34,101 DRINKING ALCOHOL OR REDUCE 2593 01:36:34,101 --> 01:36:36,204 ALCOHOL, IN TERMS OF CANCER 2594 01:36:36,204 --> 01:36:36,404 RISK. 2595 01:36:36,404 --> 01:36:38,272 OFTEN YOU GET ON THESE RISK 2596 01:36:38,272 --> 01:36:39,907 CALCULATORS ONLINE, YOU CAN PLUG 2597 01:36:39,907 --> 01:36:41,008 IN RISK FACTORS AND IT TELLS 2598 01:36:41,008 --> 01:36:43,311 WHAT YOUR RISK IS OF A VARIETY 2599 01:36:43,311 --> 01:36:43,945 OF DISEASES. 2600 01:36:43,945 --> 01:36:45,580 SOME OF THOSE RISK CALCULATORS, 2601 01:36:45,580 --> 01:36:47,381 IF YOU CLICK ON A PARTICULAR 2602 01:36:47,381 --> 01:36:49,650 BEHAVIOR, IT WILL SHOW YOU HOW 2603 01:36:49,650 --> 01:36:51,185 YOUR RISK CAN GO DOWN IF YOU 2604 01:36:51,185 --> 01:36:52,620 CHANGE THAT BEHAVIOR. 2605 01:36:52,620 --> 01:36:53,921 AND SOMETIMES THE EVIDENCE FOR 2606 01:36:53,921 --> 01:36:56,224 THAT IS NOT NECESSARILY CLEAR. 2607 01:36:56,224 --> 01:36:57,992 THERE'S A LOT OF EPIDEMIOLOGIC 2608 01:36:57,992 --> 01:36:59,293 EVIDENCE THAT LINKS A PARTICULAR 2609 01:36:59,293 --> 01:37:00,595 BEHAVIOR TO THE DEVELOPMENT OF 2610 01:37:00,595 --> 01:37:01,696 HEALTH PROBLEM BUT THAT'S NOT 2611 01:37:01,696 --> 01:37:03,764 THE SAME EVIDENCE YOU NEWED TO 2612 01:37:03,764 --> 01:37:05,633 SHOW REDUCING USE OF THAT 2613 01:37:05,633 --> 01:37:07,034 PRODUCT OR CHANGING THAT 2614 01:37:07,034 --> 01:37:08,369 BEHAVIOR MAKES YOUR RISK GO 2615 01:37:08,369 --> 01:37:10,538 DOWN. 2616 01:37:10,538 --> 01:37:13,941 AND SO THIS WORKING GROUP IARC 2617 01:37:13,941 --> 01:37:19,614 CONCLUDES REDUCTION OR 2618 01:37:19,614 --> 01:37:21,716 CESSATIONS REDUCES RISK OF ORAL 2619 01:37:21,716 --> 01:37:24,752 AND ESOPHAGEAL BUT WE NEED MORE 2620 01:37:24,752 --> 01:37:25,419 DATA, BREAST AN COLORECTAL ARE 2621 01:37:25,419 --> 01:37:28,389 TOP OF THE LIST OF CANCER SITES 2622 01:37:28,389 --> 01:37:30,725 SO IF IT TURNS OUT REDUCING 2623 01:37:30,725 --> 01:37:32,627 ALCOHOL CONSUMPTION IN YOUR 2624 01:37:32,627 --> 01:37:33,861 40s, 50s, WHATEVER, REDUCES 2625 01:37:33,861 --> 01:37:34,629 YOUR BREAST CANCER RISK, THAT 2626 01:37:34,629 --> 01:37:36,197 WOULD BE KIND OF AN IMPORTANT 2627 01:37:36,197 --> 01:37:37,898 MESSAGE FOR THE U.S. PUBLIC, 2628 01:37:37,898 --> 01:37:38,099 RIGHT? 2629 01:37:38,099 --> 01:37:40,935 SO WE NEED MORE OF THOSE KINDS 2630 01:37:40,935 --> 01:37:41,602 OF DATA. 2631 01:37:41,602 --> 01:37:43,904 I'LL WRAP UP BY SAYING THAT WE 2632 01:37:43,904 --> 01:37:44,805 HAVE ALL THESE RESOURCES WHERE 2633 01:37:44,805 --> 01:37:46,207 ONE OF MY COLLEAGUES LIKES TO 2634 01:37:46,207 --> 01:37:48,075 SAY WE'RE NOT JUST AN ATM WITH 2635 01:37:48,075 --> 01:37:49,043 GRANT MONEY. 2636 01:37:49,043 --> 01:37:50,478 WE HAVE LOTS OF RESOURCES. 2637 01:37:50,478 --> 01:37:52,179 WE LIKE TO HELP OUR EXTRAMURAL 2638 01:37:52,179 --> 01:37:52,880 COMMUNITY GET WHERE THEY ARE 2639 01:37:52,880 --> 01:37:55,616 GOING AND HERE ARE SOME 2640 01:37:55,616 --> 01:37:56,183 EXAMPLES. 2641 01:37:56,183 --> 01:37:57,718 I'VE ALREADY MENTIONED MOST. 2642 01:37:57,718 --> 01:37:59,120 FOURTH ONE DOWN CLASSIFICATION 2643 01:37:59,120 --> 01:38:00,888 OF LAWS ASSOCIATED WITH SCHOOL 2644 01:38:00,888 --> 01:38:02,189 STUDENTS, CLASS, AGAIN A GREAT 2645 01:38:02,189 --> 01:38:04,392 ACRONYM THAT I DID NOT COME UP 2646 01:38:04,392 --> 01:38:07,128 WITH, AND WHAT THAT DOES IS 2647 01:38:07,128 --> 01:38:09,964 LOOKS AT POLICIES RELATED TO 2648 01:38:09,964 --> 01:38:11,265 OBESOGENIC OUTCOMES, SO VENDING 2649 01:38:11,265 --> 01:38:13,000 MACHINE USE IN SCHOOLS, PHYSICAL 2650 01:38:13,000 --> 01:38:15,102 ACTIVITY GUIDELINES, AND SO ON. 2651 01:38:15,102 --> 01:38:16,837 HOW ARE THOSE AFFECTED TO 2652 01:38:16,837 --> 01:38:18,306 DEVELOPMENT OF OBESITY? 2653 01:38:18,306 --> 01:38:20,941 GIVEN OBESITY IS CLIMBING REALLY 2654 01:38:20,941 --> 01:38:21,575 QUITE DRAMATICALLY, POTENTIALLY 2655 01:38:21,575 --> 01:38:23,778 COULD BE THE CALLS OF INCREASING 2656 01:38:23,778 --> 01:38:25,379 RATES OF COLORECTAL CANCER IN 2657 01:38:25,379 --> 01:38:26,814 YOUNG POPULATIONS, THIS IS 2658 01:38:26,814 --> 01:38:28,282 OBVIOUSLY A VERY IMPORTANT 2659 01:38:28,282 --> 01:38:29,350 QUESTION TO BE ADDRESSING. 2660 01:38:29,350 --> 01:38:31,319 WE HAVE A COUPLE OTHER TOOLS 2661 01:38:31,319 --> 01:38:32,953 THAT GET AT DIETARY ASSESSMENT, 2662 01:38:32,953 --> 01:38:35,589 AS YOU CAN SEE HERE, AND WE HAVE 2663 01:38:35,589 --> 01:38:38,659 A LIBRARY OF WEBINARS IN ALCOHOL 2664 01:38:38,659 --> 01:38:40,094 AND TOBACCO AND FUNDING 2665 01:38:40,094 --> 01:38:40,961 OPPORTUNITIES, I WOULD ENCOURAGE 2666 01:38:40,961 --> 01:38:42,930 YOU TO TAKE A LOOK AT THAT. 2667 01:38:42,930 --> 01:38:45,433 THE LAST THING AT NCI WE CARE 2668 01:38:45,433 --> 01:38:46,834 ABOUT OUR JUNIOR SCHOLARS AND WE 2669 01:38:46,834 --> 01:38:48,269 DO A LOT OF TRAINING. 2670 01:38:48,269 --> 01:38:49,704 OBVIOUSLY WE PROVIDE K AWARDS 2671 01:38:49,704 --> 01:38:52,540 AND F AWARDS, T AWARDS, TO 2672 01:38:52,540 --> 01:38:53,541 ACADEMIC MEDICAL CENTERS, 2673 01:38:53,541 --> 01:38:54,675 UNIVERSITIES AROUND THE COUNTRY. 2674 01:38:54,675 --> 01:38:57,144 WE ALSO DO A LOT OF OUR OWN 2675 01:38:57,144 --> 01:38:58,913 TRAINING INTERNALLY AND WITHIN 2676 01:38:58,913 --> 01:39:00,815 OUR OWN DIVISION WE'VE HAD 2677 01:39:00,815 --> 01:39:01,749 APPROXIMATELY 50 FELLOWS A YEAR 2678 01:39:01,749 --> 01:39:04,151 WORKING WITH US IN VARIOUS 2679 01:39:04,151 --> 01:39:06,153 MECHANISMS, AND YOU CAN SEE THEM 2680 01:39:06,153 --> 01:39:07,221 LISTED HERE. 2681 01:39:07,221 --> 01:39:10,091 I JUST WANT TO HIGHLIGHT ONE, 2682 01:39:10,091 --> 01:39:10,958 CANCER PREVENTION FELLOWSHIP 2683 01:39:10,958 --> 01:39:11,392 PROGRAM. 2684 01:39:11,392 --> 01:39:12,993 THIS IS REALLY A TREMENDOUS 2685 01:39:12,993 --> 01:39:14,895 OPPORTUNITY, FRANKLY IF I KNEW 2686 01:39:14,895 --> 01:39:16,530 ABOUT THIS WHEN A GRADUATE 2687 01:39:16,530 --> 01:39:19,700 STUDENT I MIGHT HAVE PURSUED 2688 01:39:19,700 --> 01:39:22,870 THIS, AFTER GETTING YOUR 2689 01:39:22,870 --> 01:39:28,776 Ph.D. YOU CAN GET YOUR 2690 01:39:28,776 --> 01:39:30,644 MASTER'S IN PUBLIC HEALTH PAID 2691 01:39:30,644 --> 01:39:32,380 FOR, ANYWHERE YOU GET IN, WORK 2692 01:39:32,380 --> 01:39:34,915 AT US FOR THREE OUR FOUR YEARS 2693 01:39:34,915 --> 01:39:35,783 DOING RESEARCH POSITIONING YOU 2694 01:39:35,783 --> 01:39:36,784 FOR WHATEVER YOUR NEXT POSITION 2695 01:39:36,784 --> 01:39:38,419 IS GOING TO BE, NEXT JOB. 2696 01:39:38,419 --> 01:39:40,154 MANY OF OUR FOLKS, MANY FELLOWS, 2697 01:39:40,154 --> 01:39:42,490 MOVE ON TO GOVERNMENT JOBS, 2698 01:39:42,490 --> 01:39:45,226 ACADEMIC JOBS, JOBS IN INDUSTRY, 2699 01:39:45,226 --> 01:39:46,927 REALLY HIGH LEVEL JOBS, AND 2700 01:39:46,927 --> 01:39:48,062 THEIR TRAINING IS STELLAR 2701 01:39:48,062 --> 01:39:50,798 BECAUSE THEY NOT ONLY HAVE THEIR 2702 01:39:50,798 --> 01:39:53,601 DOCTORAL DEGREES BUT MASTER'S IN 2703 01:39:53,601 --> 01:39:54,935 PUBLIC HEALTH AND RESEARCH AT 2704 01:39:54,935 --> 01:39:55,369 NCI. 2705 01:39:55,369 --> 01:39:56,704 THE DEADLINE TO APPLY FOR THIS 2706 01:39:56,704 --> 01:39:59,440 PROGRAM IS COMING UP ON AUGUST 2707 01:39:59,440 --> 01:40:02,042 1, SO I ENCOURAGE YOU TO TALK TO 2708 01:40:02,042 --> 01:40:05,112 YOUR TALENTED GRADUATE STUDENTS 2709 01:40:05,112 --> 01:40:06,147 FINISHING SOON ABOUT APPLYING. 2710 01:40:06,147 --> 01:40:08,082 SO PLEASE STAY IN TOUCH WITH US. 2711 01:40:08,082 --> 01:40:09,817 YOU CAN SEE VARIOUS WAYS TO BE 2712 01:40:09,817 --> 01:40:10,951 IN TOUCH WITH US ABOUT OUR 2713 01:40:10,951 --> 01:40:12,686 PRIORITIES, WHAT WE'RE UP TO. 2714 01:40:12,686 --> 01:40:15,723 WE'VE GOT A WEBSITE. 2715 01:40:15,723 --> 01:40:18,793 YOU CAN PLUG IN NCI BRP AND GET 2716 01:40:18,793 --> 01:40:20,761 TO THIS JUST AS NIAAA. 2717 01:40:20,761 --> 01:40:23,063 WE HAVE A TWITTER FEED ABOUT TO 2718 01:40:23,063 --> 01:40:24,265 DISAPPEAR BECAUSE WE'RE 2719 01:40:24,265 --> 01:40:26,233 CONTRACTING OUR TWITTER ACCOUNTS 2720 01:40:26,233 --> 01:40:27,868 AT NIH, BUT IT'S STILL ACTIVE 2721 01:40:27,868 --> 01:40:29,403 NOW. 2722 01:40:29,403 --> 01:40:31,138 WE HAVE A NEWSLETTER WHICH HAS A 2723 01:40:31,138 --> 01:40:32,873 LOT OF INFORMATION I JUST TALKED 2724 01:40:32,873 --> 01:40:33,974 ABOUT. 2725 01:40:33,974 --> 01:40:36,076 AND I'LL END THERE AND THAT'S MY 2726 01:40:36,076 --> 01:40:37,511 TITLE, I SHOULD HAVE PUT MY 2727 01:40:37,511 --> 01:40:38,479 E-MAIL ON THERE. 2728 01:40:38,479 --> 01:40:40,347 YOU CAN GET TO THAT ONLINE. 2729 01:40:40,347 --> 01:40:41,882 HAPPY TO TAKE ANY QUESTIONS YOU 2730 01:40:41,882 --> 01:40:42,883 HAVE OVER E-MAIL AND CERTAINLY 2731 01:40:42,883 --> 01:40:45,820 ANY QUESTIONS HAVE YOU RIGHT 2732 01:40:45,820 --> 01:40:53,494 NOW. 2733 01:40:53,494 --> 01:40:55,029 THANK YOU. 2734 01:40:55,029 --> 01:40:55,596 NORA? 2735 01:40:55,596 --> 01:40:58,866 >> ONE QUESTION, THOSE NUMBERS, 2736 01:40:58,866 --> 01:41:00,267 I ACTUALLY HEARD GEORGE PRESENT 2737 01:41:00,267 --> 01:41:02,236 TABLES IN TERMS OF INCREASING 2738 01:41:02,236 --> 01:41:04,205 RISK FOR CANCER, EVEN THOUGH WE 2739 01:41:04,205 --> 01:41:07,741 DON'T COMPLETELY UNDERSTAND THE 2740 01:41:07,741 --> 01:41:11,312 MECHANISMS, THEY ARE SO QUITE 2741 01:41:11,312 --> 01:41:12,680 HIGH, ESOPHAGEAL CANCER 2742 01:41:12,680 --> 01:41:14,482 SOMETHING LIKE 37%, HUGE. 2743 01:41:14,482 --> 01:41:16,684 THEN SPEAKING OF THEM AS AN 2744 01:41:16,684 --> 01:41:19,987 ISOLATED ENTITY, DO WE KNOW HOW 2745 01:41:19,987 --> 01:41:25,726 THE INTERACTION WITH SMOKING 2746 01:41:25,726 --> 01:41:29,864 ACTUALLY IS IT SYNERGISTIC, 2747 01:41:29,864 --> 01:41:30,965 ADDITIVE? 2748 01:41:30,965 --> 01:41:33,400 AND WHAT IS OUR UNDERSTANDING OF 2749 01:41:33,400 --> 01:41:34,134 THE MECHANISM, INFLAMMATORY 2750 01:41:34,134 --> 01:41:34,368 PROCESS? 2751 01:41:34,368 --> 01:41:35,469 >> BEFORE I ANSWER I WANT TO GO 2752 01:41:35,469 --> 01:41:38,072 BACK TO THE POINT YOU MADE ABOUT 2753 01:41:38,072 --> 01:41:39,173 GLP AGONIST, SOMETHING WE'RE 2754 01:41:39,173 --> 01:41:42,042 THINKING ABOUT TOO NOW BECAUSE 2755 01:41:42,042 --> 01:41:43,711 GLP CAN CONNECT THOSE BEHAVIORS 2756 01:41:43,711 --> 01:41:44,845 TOGETHER IN INTERESTING WAYS. 2757 01:41:44,845 --> 01:41:48,582 WE NEED MORE DATA ON THAT 2758 01:41:48,582 --> 01:41:49,116 QUESTION. 2759 01:41:49,116 --> 01:41:56,390 WE KNOW ABOUT SOME MECHANISMS 2760 01:41:56,390 --> 01:41:59,460 THAT LINK ALCOHOL CANCER, 2761 01:41:59,460 --> 01:42:01,095 CAUSING DNA DAMAGE WHICH CAN 2762 01:42:01,095 --> 01:42:01,795 CAUSE CANCER. 2763 01:42:01,795 --> 01:42:04,899 BREAST CANCER STORY IS ABOUT 2764 01:42:04,899 --> 01:42:06,133 ESTROGEN, ALCOHOL INCREASES 2765 01:42:06,133 --> 01:42:06,901 ESTROGEN DEVELOPMENT WHICH IN 2766 01:42:06,901 --> 01:42:09,637 TURN CAN LEAD TO BREAST CANCER 2767 01:42:09,637 --> 01:42:11,138 AND OTHER CANCERS THAT ARE VERY 2768 01:42:11,138 --> 01:42:12,806 HIGH ON THE LIST FOR WOMEN. 2769 01:42:12,806 --> 01:42:14,775 WE HAVE SOME SENSE OF MECHANISMS 2770 01:42:14,775 --> 01:42:17,511 BUT STILL NEED MORE AND NEED 2771 01:42:17,511 --> 01:42:19,280 MORE ON MECHANISMS THAT EXPLAIN 2772 01:42:19,280 --> 01:42:22,349 WHY REDUCTION IN ALCOHOL USE 2773 01:42:22,349 --> 01:42:24,718 MIGHT REDUCE CANCER RISK LIKE 2774 01:42:24,718 --> 01:42:25,185 THE IARC REPORT. 2775 01:42:25,185 --> 01:42:27,354 THERE'S NOT ENOUGH OF THAT. 2776 01:42:27,354 --> 01:42:29,223 WITH REGARD TO SYNERGISTIC 2777 01:42:29,223 --> 01:42:30,324 EFFECTS OF SUBSTANCES THAT'S A 2778 01:42:30,324 --> 01:42:32,726 NEW AREA AS WELL. 2779 01:42:32,726 --> 01:42:35,229 WE HAVE A SENSE THAT THERE IS A 2780 01:42:35,229 --> 01:42:36,530 CORRELATION BETWEEN USING 2781 01:42:36,530 --> 01:42:38,399 TOBACCO AND USING ALCOHOL, BUT 2782 01:42:38,399 --> 01:42:39,066 IT'S MODEST. 2783 01:42:39,066 --> 01:42:40,601 AND THE INTERESTING THING IS IF 2784 01:42:40,601 --> 01:42:43,470 YOU LOOK AT THE PROFILE, THE 2785 01:42:43,470 --> 01:42:44,672 POPULATION PROFILE, OF TOBACCO 2786 01:42:44,672 --> 01:42:47,508 USE AND ALCOHOL USE, IT'S NOT 2787 01:42:47,508 --> 01:42:49,677 THE SAME. 2788 01:42:49,677 --> 01:42:51,545 SO, TOBACCO USERS PARTICULARLY 2789 01:42:51,545 --> 01:42:54,715 COMBUSTIBLE CIGARETTES TEND TO 2790 01:42:54,715 --> 01:42:55,916 BE CONCENTRATED IN LOWER SES, 2791 01:42:55,916 --> 01:42:58,786 PEOPLE WITH MENTAL HEALTH 2792 01:42:58,786 --> 01:43:00,854 CONDITIONS, PEOPLE IN THE 2793 01:43:00,854 --> 01:43:01,755 MILITARY, LGBTQ POPULATIONS HAVE 2794 01:43:01,755 --> 01:43:04,258 BEEN SHOWN TO BE HIGHER IN USE 2795 01:43:04,258 --> 01:43:05,559 OF COMBUSTIBLE TOBACCO. 2796 01:43:05,559 --> 01:43:07,328 THOSE ARE NOT NECESSARILY THE 2797 01:43:07,328 --> 01:43:09,496 SAME POPULATIONS USING ALCOHOL. 2798 01:43:09,496 --> 01:43:11,265 THE SINGLE BIGGEST USER IN THE 2799 01:43:11,265 --> 01:43:13,334 POPULATION OF ALCOHOL ARE US, 2800 01:43:13,334 --> 01:43:18,806 PEOPLE LIKE US PEOPLE HIGHER 2801 01:43:18,806 --> 01:43:23,210 SES, HIGHER EDUCATION AND 2802 01:43:23,210 --> 01:43:24,845 INCOME, CONSUMING ALCOHOL NOT 2803 01:43:24,845 --> 01:43:26,914 BINGE DRINKING BUT COCKTAIL 2804 01:43:26,914 --> 01:43:28,682 PARTIES AND SO FORTH. 2805 01:43:28,682 --> 01:43:30,050 TRYING TO UNDERSTAND SYNERGISTIC 2806 01:43:30,050 --> 01:43:30,851 EFFECTS IS COMPLICATED BECAUSE 2807 01:43:30,851 --> 01:43:33,387 OF OVERLAP IN USE OF SUBSTANCES 2808 01:43:33,387 --> 01:43:34,388 IS CERTAINLY THERE, NOT AS MUCH 2809 01:43:34,388 --> 01:43:36,256 AS YOU WOULD EXPECT. 2810 01:43:36,256 --> 01:43:40,427 THEN YOU THROW CANNABIS ON TOP 2811 01:43:40,427 --> 01:43:47,635 OF THAT, THE OVERLAP, THE VENN 2812 01:43:47,635 --> 01:43:49,370 DIAGRAM, THE CIRCLE GETS 2813 01:43:49,370 --> 01:43:49,603 SMALLER. 2814 01:43:49,603 --> 01:43:50,804 WHAT POLICY IMPLICATIONS MIGHT 2815 01:43:50,804 --> 01:43:51,772 LOOK LIKE FOR ANY OF THE THREE 2816 01:43:51,772 --> 01:43:53,307 ON THE USE OF THE OTHER THREE. 2817 01:43:53,307 --> 01:43:55,175 >> I REALIZE IT'S NOT EXACTLY 2818 01:43:55,175 --> 01:43:57,444 THE SAME DEMOGRAPHIC BUT IF 2819 01:43:57,444 --> 01:43:58,679 THERE IS A SYNERGISTIC EFFECT, 2820 01:43:58,679 --> 01:44:01,181 SOMEONE SMOKING, EVEN IF THEY 2821 01:44:01,181 --> 01:44:02,950 DON'T DRINK REGULARLY, DOES THAT 2822 01:44:02,950 --> 01:44:05,152 REALLY INCREASE THE TOXICITY OF 2823 01:44:05,152 --> 01:44:05,386 ALCOHOL? 2824 01:44:05,386 --> 01:44:05,786 THAT'S WHERE. 2825 01:44:05,786 --> 01:44:08,322 SO ONE OF THE THINGS I WOULD 2826 01:44:08,322 --> 01:44:11,058 LOVE TO SEE PRESENTED OR 2827 01:44:11,058 --> 01:44:13,027 ANALYZED IS WHAT IS THE 2828 01:44:13,027 --> 01:44:14,795 CONTRIBUTION OF ALCOHOL BY 2829 01:44:14,795 --> 01:44:17,297 ITSELF OR WITH TOBACCO AS A 2830 01:44:17,297 --> 01:44:19,933 FUNCTION OF DEMOGRAPHIC, SO IF 2831 01:44:19,933 --> 01:44:24,104 YOU COME FROM LOW INCOME AND 2832 01:44:24,104 --> 01:44:25,639 DEPRIVED ENVIRONMENT WHAT EXTENT 2833 01:44:25,639 --> 01:44:27,608 ACCOUNTS FOR CONTRIBUTION IN 2834 01:44:27,608 --> 01:44:30,544 EMERGENCE OF CANCERS, ARE THERE 2835 01:44:30,544 --> 01:44:31,211 STATISTICS ON IT? 2836 01:44:31,211 --> 01:44:34,048 IN TERMS OF INCOME AND SOCIAL 2837 01:44:34,048 --> 01:44:34,548 AND ECONOMICAL FACTORS? 2838 01:44:34,548 --> 01:44:36,483 >> YES, THERE ARE SOME DATA LIKE 2839 01:44:36,483 --> 01:44:37,351 THAT. 2840 01:44:37,351 --> 01:44:39,520 WE DO KNOW THAT DIFFERENT TYPES 2841 01:44:39,520 --> 01:44:41,655 OF ALCOHOL PRODUCTS ARE USED 2842 01:44:41,655 --> 01:44:42,489 DIFFERENTIALLY IN DIFFERENT 2843 01:44:42,489 --> 01:44:43,023 POPULATIONS. 2844 01:44:43,023 --> 01:44:45,059 FOR EXAMPLE, BEER TENDS TO BE 2845 01:44:45,059 --> 01:44:54,101 USED AT LOWER SOCIOECONOMIC 2846 01:44:54,101 --> 01:44:56,937 STRATA, WINE AT HIGHER, 2847 01:44:56,937 --> 01:44:57,738 IRRELEVANT, IT'S THE ETHYL 2848 01:44:57,738 --> 01:44:59,139 ALCOHOL IN THE WINE AND BEER 2849 01:44:59,139 --> 01:45:01,108 THAT HAS EFFECT, NOTHING ABOUT 2850 01:45:01,108 --> 01:45:02,543 THE ALCOHOL PRODUCT IN 2851 01:45:02,543 --> 01:45:02,843 PARTICULAR. 2852 01:45:02,843 --> 01:45:04,411 AND IN FACT GEORGE MENTIONED 2853 01:45:04,411 --> 01:45:06,613 SOME DATA SHOWING THAT PEOPLE 2854 01:45:06,613 --> 01:45:08,115 THINK THAT WINE REDUCES CANCER 2855 01:45:08,115 --> 01:45:09,316 BY 10%. 2856 01:45:09,316 --> 01:45:11,518 THEY DIDN'T THINK THAT ABOUT 2857 01:45:11,518 --> 01:45:11,785 SPIRITS. 2858 01:45:11,785 --> 01:45:12,786 SO, PEOPLE HAVE INTERESTING 2859 01:45:12,786 --> 01:45:14,888 VIEWS ABOUT HOW DIFFERENT KINDS 2860 01:45:14,888 --> 01:45:15,789 OF ALCOHOL CAN AFFECT CANCER 2861 01:45:15,789 --> 01:45:19,059 WHEN IN FACT IT REALLY IS 2862 01:45:19,059 --> 01:45:19,493 IRRELEVANT. 2863 01:45:19,493 --> 01:45:21,161 AND THERE ARE CERTAINLY 2864 01:45:21,161 --> 01:45:22,796 POTENTIALLY HEALTH BENEFITS OF 2865 01:45:22,796 --> 01:45:24,732 RED WINE BECAUSE OF RESVERATROL 2866 01:45:24,732 --> 01:45:28,469 BUT THE THING ABOUT RESVERATROL 2867 01:45:28,469 --> 01:45:31,238 YOU HAVE TO DRINK GALLONS TO GET 2868 01:45:31,238 --> 01:45:33,207 THE HEALTH BENEFIT, YOU COULD 2869 01:45:33,207 --> 01:45:36,310 JUST DRINK GRAPE JUICE INSTEAD, 2870 01:45:36,310 --> 01:45:37,811 MAYBE WITHOUT THE SUGAR. 2871 01:45:37,811 --> 01:45:38,779 IT'S VERY COMPLICATED. 2872 01:45:38,779 --> 01:45:41,715 TO YOUR POINT WE NEED MORE DATA 2873 01:45:41,715 --> 01:45:42,449 UNDERSTANDING WHAT THE 2874 01:45:42,449 --> 01:45:44,918 MECHANISMS ARE THAT ARE 2875 01:45:44,918 --> 01:45:46,320 CONNECTING THOSE TOGETHER AND 2876 01:45:46,320 --> 01:45:47,187 WHETHER THERE ARE SYNERGISTIC 2877 01:45:47,187 --> 01:45:47,421 EFFECTS. 2878 01:45:47,421 --> 01:45:51,325 WE DON'T HAVE ENOUGH OF THAT 2879 01:45:51,325 --> 01:45:51,658 YET. 2880 01:45:51,658 --> 01:45:54,628 >> THEN YOU CAN SORT OF CONTROL 2881 01:45:54,628 --> 01:45:55,929 VERY MUCH THE DOSE EFFECT, 2882 01:45:55,929 --> 01:45:57,030 CHRONICITY, THE PERIOD AT WHICH 2883 01:45:57,030 --> 01:45:59,333 YOU GET EXPOSED IN YOUR 2884 01:45:59,333 --> 01:45:59,767 LIFETIME. 2885 01:45:59,767 --> 01:46:01,635 THE FACTORS THAT WOULD HELP US 2886 01:46:01,635 --> 01:46:02,836 UNDERSTAND IT BETTER. 2887 01:46:02,836 --> 01:46:03,704 >> YES, EXACTLY. 2888 01:46:03,704 --> 01:46:04,605 >> QUITE IMPORTANT. 2889 01:46:04,605 --> 01:46:07,307 >> YEAH, NIAAA OF COURSE HAS 2890 01:46:07,307 --> 01:46:09,743 DONE TERRIFIC WORK UNDERSTANDING 2891 01:46:09,743 --> 01:46:15,415 LIFESPAN IMPACT ON ALCOHOL 2892 01:46:15,415 --> 01:46:15,949 CONSUMPTION. 2893 01:46:15,949 --> 01:46:16,950 SPENT LITTLE TIME TALKING ABOUT 2894 01:46:16,950 --> 01:46:18,385 KIDS OTHER THAN PEDIATRIC CANCER 2895 01:46:18,385 --> 01:46:27,694 SURVIVORS BUT WE NEED TO BECAUSE 2896 01:46:27,694 --> 01:46:31,031 EXPOSURE TO ALCOHOL MEANS 2897 01:46:31,031 --> 01:46:33,200 SOMETHING AT 13 WHEN YOU'RE 2898 01:46:33,200 --> 01:46:34,034 DEVELOPING, WE'VE DEVELOPED SOME 2899 01:46:34,034 --> 01:46:36,136 OF THAT KIND OF WORK BUT MORE 2900 01:46:36,136 --> 01:46:39,640 NEEDS TO BE DONE. 2901 01:46:39,640 --> 01:46:43,443 2902 01:46:43,443 --> 01:46:45,846 >> CAN YOU SAY MORE ABOUT 2903 01:46:45,846 --> 01:46:48,816 INTEREST AT NCI, LOOKING AT 2904 01:46:48,816 --> 01:46:50,884 DIFFERENTIAL EFFECTS OF POLICIES 2905 01:46:50,884 --> 01:46:52,753 ON SUBSTANCE USE? 2906 01:46:52,753 --> 01:46:53,353 >> YEAH, SO -- 2907 01:46:53,353 --> 01:46:54,488 >> HEALTH OUTCOMES. 2908 01:46:54,488 --> 01:46:59,259 >> WE'VE BEEN VERY ENGAGED IN 2909 01:46:59,259 --> 01:46:59,726 THAT. 2910 01:46:59,726 --> 01:47:01,662 THE WORD "POLICY" CAN BE FRAUGHT 2911 01:47:01,662 --> 01:47:02,629 BECAUSE WE DON'T DO POLICY AT 2912 01:47:02,629 --> 01:47:05,732 NIH BUT WE DO WORK THAT INFORMS 2913 01:47:05,732 --> 01:47:07,034 RESEARCH AND WE HAVE TO BE 2914 01:47:07,034 --> 01:47:08,902 CAREFUL TALKING ABOUT FUNDING 2915 01:47:08,902 --> 01:47:09,670 INITIATIVES TO MAKE IT CLEAR 2916 01:47:09,670 --> 01:47:11,071 THAT'S WHAT IT'S ABOUT, 2917 01:47:11,071 --> 01:47:12,272 INFORMING POLICY. 2918 01:47:12,272 --> 01:47:13,707 BEST EXAMPLE OF THAT IS 2919 01:47:13,707 --> 01:47:15,576 COLLABORATION WITH FDA THAT I 2920 01:47:15,576 --> 01:47:15,843 MENTIONED. 2921 01:47:15,843 --> 01:47:18,545 SO FDA HAS CENTER FOR TOBACCO 2922 01:47:18,545 --> 01:47:21,181 PRODUCTS, THEIR JOB IS TO 2923 01:47:21,181 --> 01:47:22,583 REGULATE TOBACCO, AS OF 2009. 2924 01:47:22,583 --> 01:47:25,085 IT'S A NEW THING. 2925 01:47:25,085 --> 01:47:26,286 AND WE COLLABORATE WITH THEM 2926 01:47:26,286 --> 01:47:27,754 QUITE A BIT. 2927 01:47:27,754 --> 01:47:30,591 NOW, THEY WANT TO KNOW WHAT 2928 01:47:30,591 --> 01:47:32,659 KINDS OF WARNING LABELS SHOULD 2929 01:47:32,659 --> 01:47:35,062 WE PUT ON CIGARETTE PACKS? 2930 01:47:35,062 --> 01:47:35,929 OTHER COUNTRIES HAVE GRAPHIC 2931 01:47:35,929 --> 01:47:37,130 WARNING LABELS ON CIGARETTE 2932 01:47:37,130 --> 01:47:38,131 PACKS, RIGHT? 2933 01:47:38,131 --> 01:47:39,867 WE DON'T HAVE THAT. 2934 01:47:39,867 --> 01:47:40,734 WE'VE BEEN TRYING. 2935 01:47:40,734 --> 01:47:44,037 IT'S TAKEN A LONG TIME, A LOT OF 2936 01:47:44,037 --> 01:47:44,838 LITIGATION AND THE INDUSTRY 2937 01:47:44,838 --> 01:47:46,006 INVOLVED DOESN'T WANT THOSE 2938 01:47:46,006 --> 01:47:48,308 LABELS ON THOSE PACKS, RIGHT? 2939 01:47:48,308 --> 01:47:49,509 AND SO ONE OF THE THINGS THEY 2940 01:47:49,509 --> 01:47:51,612 WOULD LIKE TO KNOW FROM US IS 2941 01:47:51,612 --> 01:47:52,713 WHAT ARE THE LABELS THAT ARE 2942 01:47:52,713 --> 01:47:55,215 GOING TO BE MOST IMPACTFUL? 2943 01:47:55,215 --> 01:47:57,050 SO WE HAVE FUNDED RESEARCHERS TO 2944 01:47:57,050 --> 01:47:59,286 BE ABLE TO TEST DIFFERENT KINDS 2945 01:47:59,286 --> 01:48:00,821 OF LABELS, DIFFERENT MESSAGES TO 2946 01:48:00,821 --> 01:48:01,889 SEE WHAT'S MOST IMPACTFUL. 2947 01:48:01,889 --> 01:48:03,957 ONE OF THE ISSUES THAT CAME UP 2948 01:48:03,957 --> 01:48:06,260 IN LITIGATION WHICH I FOUND 2949 01:48:06,260 --> 01:48:08,462 INTERESTING IS THAT THE COURTS 2950 01:48:08,462 --> 01:48:09,863 CONSIDERED GRAPHIC WARNING 2951 01:48:09,863 --> 01:48:13,166 LABELS TO BE TOO EMOTIONAL, 2952 01:48:13,166 --> 01:48:14,735 FOCUSING ON SCARE TACTICS AS 2953 01:48:14,735 --> 01:48:16,370 OPPOSED TO BEING INFORMATIONAL. 2954 01:48:16,370 --> 01:48:18,438 I'M A SOCIAL PSYCHOLOGIST, 2955 01:48:18,438 --> 01:48:20,507 BEHAVIORAL SCIENTISTS KNOW 2956 01:48:20,507 --> 01:48:21,708 AFFECT IS NOT SEPARABLE FROM 2957 01:48:21,708 --> 01:48:22,276 COGNITION. 2958 01:48:22,276 --> 01:48:28,949 IT'S ALL TIED UP, RIGHT? 2959 01:48:28,949 --> 01:48:34,855 THOUGH 2960 01:48:34,855 --> 01:48:38,825 YEAH, SO EMOTION AND COGNITION 2961 01:48:38,825 --> 01:48:40,794 ARE WOVEN TOGETHER AND SO OUR 2962 01:48:40,794 --> 01:48:43,096 RESEARCHERS HAVE BEEN DOING RETO 2963 01:48:43,096 --> 01:48:44,831 HELP UNDERSTAND WHAT ARE THE 2964 01:48:44,831 --> 01:48:46,500 AFFECTIVE AND COGNITIVE EFFECTS 2965 01:48:46,500 --> 01:48:50,304 OF SEEING THESE LABELS AND 2966 01:48:50,304 --> 01:48:51,305 IMPACT ON DEVELOPING POLICY 2967 01:48:51,305 --> 01:48:52,506 ABOUT DEVELOPMENT OF THOSE 2968 01:48:52,506 --> 01:48:55,275 LABELS, TRUE FOR WARNING LABELS, 2969 01:48:55,275 --> 01:48:56,576 CORRECTIVE STATEMENTS I 2970 01:48:56,576 --> 01:48:58,011 MENTIONED BEFORE. 2971 01:48:58,011 --> 01:48:58,979 SMOKE-FREE POLICIES AND OTHER 2972 01:48:58,979 --> 01:48:59,947 KINDS OF POLICIES. 2973 01:48:59,947 --> 01:49:01,481 THAT'S THE PLACE WE'VE DONE THE 2974 01:49:01,481 --> 01:49:01,915 MOST. 2975 01:49:01,915 --> 01:49:03,550 AND WE WOULD LOVE TO DO MORE 2976 01:49:03,550 --> 01:49:05,419 WITH REGARD TO CANNABIS POLICY, 2977 01:49:05,419 --> 01:49:07,387 ALCOHOL POLICY, WE DO A LOT WITH 2978 01:49:07,387 --> 01:49:09,556 HEALTH CARE POLICY AS WELL IN 2979 01:49:09,556 --> 01:49:16,330 OUR SISTER HEALTH CARE DELIVERY 2980 01:49:16,330 --> 01:49:18,966 RESEARCH PROGRAM. 2981 01:49:18,966 --> 01:49:23,837 2982 01:49:23,837 --> 01:49:26,773 >> IT'S A PLEASURE TO PRESENT 2983 01:49:26,773 --> 01:49:31,712 DR. KATHY COLE, DR. CHLOE JORDAN 2984 01:49:31,712 --> 01:49:33,880 AND JANANI PRABHAKAR FOR AN 2985 01:49:33,880 --> 01:49:35,849 UPDATE ON THE ABCD STUDY. 2986 01:49:35,849 --> 01:49:40,354 DR. COLE IS THE PROGRAM MANAGER, 2987 01:49:40,354 --> 01:49:42,990 DR. JORDAN IS SCIENTIFIC PROGRAM 2988 01:49:42,990 --> 01:49:45,826 MANAGER, AND DR. PRABHAKAR IS 2989 01:49:45,826 --> 01:49:47,694 PROGRAM OFFICIAL FOR HBCD STUDY. 2990 01:49:47,694 --> 01:49:49,863 TODAY THEY WILL BE PROVIDING 2991 01:49:49,863 --> 01:49:54,868 UPDATES ON THE STUDY OVER THE 2992 01:49:54,868 --> 01:49:55,669 PAST YEAR. 2993 01:49:55,669 --> 01:49:58,839 >> THANK YOU FOR THE KIND 2994 01:49:58,839 --> 01:49:59,172 INTRODUCTION. 2995 01:49:59,172 --> 01:50:01,041 I'LL MAKE SURE THE SLIDES CAN 2996 01:50:01,041 --> 01:50:08,715 CLICK BEFORE I GET STARTED. 2997 01:50:08,715 --> 01:50:11,651 I THINK THE POINTER CAN WORK. 2998 01:50:11,651 --> 01:50:12,185 THANK YOU. 2999 01:50:12,185 --> 01:50:15,489 IT'S MY PLEASURE TO BE HERE TO 3000 01:50:15,489 --> 01:50:17,791 PRESENT TO THE COUNCIL, UPDATES 3001 01:50:17,791 --> 01:50:25,999 AND PROGRESS OF THE HBCD STUDY 3002 01:50:25,999 --> 01:50:29,269 WITH MY COLLEAGUES, DR. JORDAN 3003 01:50:29,269 --> 01:50:30,137 WILL JOIN US VIRTUALLY, 3004 01:50:30,137 --> 01:50:35,075 HOPEFULLY YOU'LL SEE HER ON THE 3005 01:50:35,075 --> 01:50:38,478 SCREEN AND DR. PRABHAKAR, THE 3006 01:50:38,478 --> 01:50:39,913 SCIENTIFIC PROGRAM OFFICER. 3007 01:50:39,913 --> 01:50:44,284 SO WHAT IS THE HBCD STUDY? 3008 01:50:44,284 --> 01:50:45,719 IT IS A TEN-YEAR LONGITUDINAL 3009 01:50:45,719 --> 01:50:47,754 STUDY LOOKING AT EARLY BRAIN AND 3010 01:50:47,754 --> 01:50:48,455 CHILD DEVELOPMENT. 3011 01:50:48,455 --> 01:50:51,425 IT'S GOING TO INVOLVE THE 3012 01:50:51,425 --> 01:50:52,659 COLLABORATIVE WORK OF 27 3013 01:50:52,659 --> 01:50:56,296 RESEARCH SITES ACROSS THE U.S. 3014 01:50:56,296 --> 01:50:57,531 THIS WILL BE RECRUITING 3015 01:50:57,531 --> 01:50:59,833 PARTICIPANTS STARTING IN THEIR 3016 01:50:59,833 --> 01:51:01,134 SECOND TRIMESTER OF PREGNANCY, 3017 01:51:01,134 --> 01:51:02,469 AND FOLLOWING THEM AND CHILDREN 3018 01:51:02,469 --> 01:51:07,707 THROUGH FIRST DECADE OF LIFE. 3019 01:51:07,707 --> 01:51:09,376 IT'S AMBITIOUS PROTOCOL WITH 3020 01:51:09,376 --> 01:51:12,079 ASSESSMENT OF BRAIN, COGNITIVE, 3021 01:51:12,079 --> 01:51:15,515 ENOTIONAL DEVELOPMENT STARTING 3022 01:51:15,515 --> 01:51:17,684 FROM BIRTH. 3023 01:51:17,684 --> 01:51:18,985 THE GOAL TO RECRUITED 7,000 3024 01:51:18,985 --> 01:51:21,988 PARTICIPANTS, TO BE ABLE TO 3025 01:51:21,988 --> 01:51:22,656 CHARACTERIZE NEURODEVELOPMENTAL 3026 01:51:22,656 --> 01:51:24,724 TRAJECTORIES, AS WELL AS 3027 01:51:24,724 --> 01:51:26,259 DETERMINE HOW SUBSTANCE EXPOSURE 3028 01:51:26,259 --> 01:51:28,995 AND EXPOSURE TO OTHER SOCIAL AND 3029 01:51:28,995 --> 01:51:30,430 ENVIRONMENTAL DETERMINANTS OF 3030 01:51:30,430 --> 01:51:32,833 HEALTH MAY IMPACT THESE 3031 01:51:32,833 --> 01:51:33,166 TRAJECTORIES. 3032 01:51:33,166 --> 01:51:35,435 DATA COLLECTED FROM THIS STUDY 3033 01:51:35,435 --> 01:51:38,071 WILL BE WIDELY SHARED WITH 3034 01:51:38,071 --> 01:51:38,638 SCIENTIFIC COMMUNITY, ANNUAL 3035 01:51:38,638 --> 01:51:39,639 DATA RELEASES. 3036 01:51:39,639 --> 01:51:40,707 WITH OUR FIRST RELEASE PLANNED 3037 01:51:40,707 --> 01:51:45,445 FOR THE END OF THIS YEAR, 3038 01:51:45,445 --> 01:51:48,048 STARTING EARLY NEXT YEAR. 3039 01:51:48,048 --> 01:51:51,184 THE HBCD STUDY IS FUNDED IN PART 3040 01:51:51,184 --> 01:51:56,556 BY THE HEAL INITIATIVE, AS WELL 3041 01:51:56,556 --> 01:52:02,062 AS SUPPORT OF 12 INSTITUTES AND 3042 01:52:02,062 --> 01:52:02,929 CENTERS, ALL LISTED. 3043 01:52:02,929 --> 01:52:10,904 I GUESS YOU CAN SEE IT, 12 3044 01:52:10,904 --> 01:52:14,841 INSTITUTES LISTED THERE. 3045 01:52:14,841 --> 01:52:18,645 SO THE HBCD CONSORTIUM IS 27 3046 01:52:18,645 --> 01:52:20,647 RECRUITMENT SITES ACROSS 24 U01 3047 01:52:20,647 --> 01:52:21,848 AWARDS, 20 STATES. 3048 01:52:21,848 --> 01:52:25,352 YOU CAN SEE THEM ALL WITH THE 3049 01:52:25,352 --> 01:52:27,220 BLACK PINPOINT. 3050 01:52:27,220 --> 01:52:30,924 THERE'S A COORDINATING CENTER, 3051 01:52:30,924 --> 01:52:32,926 SO ADMINISTRATIVE CORE, THE 3052 01:52:32,926 --> 01:52:35,962 HCAC, YOU CAN SEE THOSE IN 3053 01:52:35,962 --> 01:52:36,196 ORANGE. 3054 01:52:36,196 --> 01:52:37,931 THAT INCLUDES UNIVERSITY OF 3055 01:52:37,931 --> 01:52:39,799 CALIFORNIA SAN DIEGO, AND BOSTON 3056 01:52:39,799 --> 01:52:41,101 CHILDREN'S HOSPITAL. 3057 01:52:41,101 --> 01:52:43,303 THERE'S A DATA COORDINATING 3058 01:52:43,303 --> 01:52:46,239 CENTER AS WELL, IT IS 3059 01:52:46,239 --> 01:52:48,341 HIGHLIGHTED IN BLUE PINPOINT, 3060 01:52:48,341 --> 01:52:51,811 ALSO BASED AT THREE INSTITUTES, 3061 01:52:51,811 --> 01:52:55,615 AT WASHINGTON UNIVERSITY ST. 3062 01:52:55,615 --> 01:52:56,983 LOUIS, UNIVERSITY OF MINNESOTA, 3063 01:52:56,983 --> 01:53:00,820 AND UNIVERSITY OF CALIFORNIA SAN 3064 01:53:00,820 --> 01:53:01,588 DIEGO. 3065 01:53:01,588 --> 01:53:04,758 SO THERE ARE MULTIPLE SCIENTIFIC 3066 01:53:04,758 --> 01:53:06,059 QUESTIONS THAT THE STUDY HOPES 3067 01:53:06,059 --> 01:53:07,060 TO ANSWER. 3068 01:53:07,060 --> 01:53:10,897 FIRST BEING AN UNDERSTANDING OF 3069 01:53:10,897 --> 01:53:11,965 TYPICAL NEURODEVELOPMENTAL 3070 01:53:11,965 --> 01:53:12,299 TRAJECTORIES. 3071 01:53:12,299 --> 01:53:16,570 UNDERSTANDING OF NORMAL RANGE OF 3072 01:53:16,570 --> 01:53:17,337 VARIABILITY IN THESE 3073 01:53:17,337 --> 01:53:17,771 TRAJECTORIES. 3074 01:53:17,771 --> 01:53:21,474 WE ALSO HOPE TO UNDERSTAND HOW 3075 01:53:21,474 --> 01:53:22,842 GENETIC INFLUENCES CAN INTERACT 3076 01:53:22,842 --> 01:53:26,179 WITH ENVIRONMENTAL FACTORS TO 3077 01:53:26,179 --> 01:53:27,948 HELP INFLUENCE DEVELOPMENT, 3078 01:53:27,948 --> 01:53:29,950 NEUROCOGNITIVE DEVELOPMENT, 3079 01:53:29,950 --> 01:53:32,986 EMOTIONAL AND SOCIAL 3080 01:53:32,986 --> 01:53:33,820 DEVELOPMENT. 3081 01:53:33,820 --> 01:53:35,488 FURTHERMORE WE WANT TO INSURE 3082 01:53:35,488 --> 01:53:41,428 HOW OPIOIDS AND SUBSTANCES 3083 01:53:41,428 --> 01:53:48,535 INCLUDING ADVERSE ENVIRONMENTAL 3084 01:53:48,535 --> 01:53:50,503 FACTORS INFLUENCE TRAJECTORIES, 3085 01:53:50,503 --> 01:53:51,705 WINDOWS FOR AMELIORATING 3086 01:53:51,705 --> 01:53:53,340 INFLUENCES CAN IMPACT THESE 3087 01:53:53,340 --> 01:53:53,907 TRAJECTORIES. 3088 01:53:53,907 --> 01:53:57,611 THERE'S A NEED AND WANT TO 3089 01:53:57,611 --> 01:53:59,479 UNDERSTAND HOW PARENT CARETAKER 3090 01:53:59,479 --> 01:54:02,515 INTERACTIONS WITH CHILDREN MAY 3091 01:54:02,515 --> 01:54:09,556 HELP INFORM CHILD HEALTH 3092 01:54:09,556 --> 01:54:09,889 OUTCOMES. 3093 01:54:09,889 --> 01:54:11,958 SO THIS SCHEMATIC HERE BROADLY 3094 01:54:11,958 --> 01:54:12,726 REPRESENTS SOME ASSESSMENT 3095 01:54:12,726 --> 01:54:14,794 DOMAINS OF THE STUDY. 3096 01:54:14,794 --> 01:54:18,732 SO PARTICIPANTS WILL COMPLETE AN 3097 01:54:18,732 --> 01:54:19,733 EXTENSIVE BATTERY OF TESTS, 3098 01:54:19,733 --> 01:54:20,400 QUESTIONNAIRES, RESEARCH 3099 01:54:20,400 --> 01:54:21,735 ACTIVITIES RELATED TO 3100 01:54:21,735 --> 01:54:24,337 DEVELOPMENTAL ORIGINS OF 3101 01:54:24,337 --> 01:54:25,338 DISEASE. 3102 01:54:25,338 --> 01:54:25,972 PRE-PREGNANCY AND PRENATAL 3103 01:54:25,972 --> 01:54:28,842 FACTORS WILL BE ASSESSED TO 3104 01:54:28,842 --> 01:54:30,343 UNDERSTAND FACTORS THAT MAY 3105 01:54:30,343 --> 01:54:32,212 AFFECT HEALTH, STARTING AT 3106 01:54:32,212 --> 01:54:32,512 ENROLLMENT. 3107 01:54:32,512 --> 01:54:35,048 WE'LL BE LOOKING AT ONGOING 3108 01:54:35,048 --> 01:54:36,349 BIOLOGICAL FACTORS, RELATED TO 3109 01:54:36,349 --> 01:54:39,219 BOTH CHILD AND THE ADULT 3110 01:54:39,219 --> 01:54:39,519 PARTICIPANT. 3111 01:54:39,519 --> 01:54:40,520 WE'LL LOOK AT AND TRYING TO 3112 01:54:40,520 --> 01:54:41,821 UNDERSTAND PARENT AND CHILD 3113 01:54:41,821 --> 01:54:44,557 FACTORS SUCH AS PARENT CAREGIVER 3114 01:54:44,557 --> 01:54:46,092 OR CHILD CAREGIVER 3115 01:54:46,092 --> 01:54:47,627 RELATIONSHIPS, HOME ENVIRONMENT, 3116 01:54:47,627 --> 01:54:50,130 AS WELL AS MENTAL HEALTH. 3117 01:54:50,130 --> 01:54:52,232 FINALLY IMPORTANTLY WE WANT TO 3118 01:54:52,232 --> 01:54:54,301 LOOK AT AND UNDERSTAND HOW 3119 01:54:54,301 --> 01:54:55,635 SOCIAL AND ENVIRONMENTAL 3120 01:54:55,635 --> 01:54:58,171 DETERMINANTS OF HEALTH SUCH AS 3121 01:54:58,171 --> 01:55:01,541 EARLY LIFE STRESS, EXPOSURE TO 3122 01:55:01,541 --> 01:55:02,242 POVERTY AND DISCRIMINATION MIGHT 3123 01:55:02,242 --> 01:55:03,410 AFFECT TRAJECTORIES TO 3124 01:55:03,410 --> 01:55:09,783 UNDERSTAND HOW FACTORS MAY SHAPE 3125 01:55:09,783 --> 01:55:10,550 COGNITIVE AND NEUROLOGICAL 3126 01:55:10,550 --> 01:55:10,850 DEVELOPMENT. 3127 01:55:10,850 --> 01:55:15,989 IN ORDER TO TRY TO UNDERSTAND 3128 01:55:15,989 --> 01:55:18,091 ALL THESE SUBJECT MATTER DOMAINS 3129 01:55:18,091 --> 01:55:21,261 THAT WE'RE INTERESTED IN, THE 3130 01:55:21,261 --> 01:55:22,562 STRUCTURE OF THE HBCD STUDY 3131 01:55:22,562 --> 01:55:24,631 RELIES ON WORK GROUPS AND WORK 3132 01:55:24,631 --> 01:55:28,134 GROUP ORGANIZATION, SO THAT'S 3133 01:55:28,134 --> 01:55:30,337 THIS BUSY RAINBOW SLIDE TO SHOW 3134 01:55:30,337 --> 01:55:34,808 BREAD BREADTH AND DEPTH OF WORK 3135 01:55:34,808 --> 01:55:39,079 GROUPS, MADE OF SUBJECT MATTER 3136 01:55:39,079 --> 01:55:42,582 EXPERTS, INCLUDING PRINCIPAL 3137 01:55:42,582 --> 01:55:43,249 INVESTIGATORS, CO-INVESTIGATORS, 3138 01:55:43,249 --> 01:55:46,453 STUDY STAFF ACROSS 27 DIFFERENT 3139 01:55:46,453 --> 01:55:48,488 RESEARCH SITES. 3140 01:55:48,488 --> 01:55:52,425 THE WORK GROUPS SPAN ALL 3141 01:55:52,425 --> 01:55:53,393 ASPECTS. 3142 01:55:53,393 --> 01:55:55,261 HIGHLIGHTED HERE ARE WORK GROUPS 3143 01:55:55,261 --> 01:55:58,031 ASSOCIATED CLOSELY WITH ACTUAL 3144 01:55:58,031 --> 01:56:00,867 PROTOCOL AND EXECUTION OF THE 3145 01:56:00,867 --> 01:56:02,268 PROTOCOL INCLUDING WORK GROUPS 3146 01:56:02,268 --> 01:56:05,372 RELATED TO DIFFERENT AND VARIOUS 3147 01:56:05,372 --> 01:56:06,539 ASSESSMENT DOMAINS, 3148 01:56:06,539 --> 01:56:07,540 NEUROIMAGING, USE OF TECHNOLOGY 3149 01:56:07,540 --> 01:56:09,442 WITHIN THE STUDY, AS WELL AS 3150 01:56:09,442 --> 01:56:12,045 GROUPS RELATED TO STUDY DESIGN 3151 01:56:12,045 --> 01:56:16,583 AND STUDY MONITORING IN AN 3152 01:56:16,583 --> 01:56:17,617 ONGOING WAY. 3153 01:56:17,617 --> 01:56:19,819 THERE ARE SEVERAL GROUPS 3154 01:56:19,819 --> 01:56:21,354 DEDICATED TO PARTICIPANT 3155 01:56:21,354 --> 01:56:23,757 EXPERIENCE, WHICH WITHIN THE 3156 01:56:23,757 --> 01:56:26,292 HBCD CONSORTIUM WE CALL HBCD 3157 01:56:26,292 --> 01:56:27,394 EXPERIENCE BECAUSE OUR 3158 01:56:27,394 --> 01:56:29,229 PARTICIPANTS AND THEM FEELING 3159 01:56:29,229 --> 01:56:30,130 INVOLVED AND INCLUDED IS VERY 3160 01:56:30,130 --> 01:56:32,866 IMPORTANT FOR US IN THE STUDY. 3161 01:56:32,866 --> 01:56:34,401 THIS INCLUDES GROUPS RELATED 3162 01:56:34,401 --> 01:56:35,268 SPECIFICALLY TO RECRUITMENT AND 3163 01:56:35,268 --> 01:56:38,037 RETENTION OF THIS VERY IMPORTANT 3164 01:56:38,037 --> 01:56:38,638 POPULATION. 3165 01:56:38,638 --> 01:56:39,572 WORK GROUPS RELATED TO 3166 01:56:39,572 --> 01:56:42,175 UNDERSTANDING NEEDS OF RURAL AND 3167 01:56:42,175 --> 01:56:44,077 SOVEREIGN COMMUNITIES, WORK 3168 01:56:44,077 --> 01:56:45,912 GROUPS RELATED TO EMPOWERING AND 3169 01:56:45,912 --> 01:56:47,547 HELPING INFORM OUR STUDY 3170 01:56:47,547 --> 01:56:48,648 NAVIGATORS WHICH ARE LOCATED 3171 01:56:48,648 --> 01:56:50,350 ACROSS SITES, AND THESE ARE 3172 01:56:50,350 --> 01:56:52,485 FOLKS THAT ARE TRYING TO GUIDE 3173 01:56:52,485 --> 01:56:54,788 PARTICIPANT THROUGH THE RESEARCH 3174 01:56:54,788 --> 01:56:56,122 PROTOCOL AND MANY OF THESE STUDY 3175 01:56:56,122 --> 01:57:01,194 AND A NAVIGATORS HAVE LIVED 3176 01:57:01,194 --> 01:57:03,930 EXPERIENCE, A GROUP FOCUSED ON 3177 01:57:03,930 --> 01:57:06,232 TRANSITION IN CARE IN CASE 3178 01:57:06,232 --> 01:57:08,034 PARTICIPANTS LOSE CUSTODY OF 3179 01:57:08,034 --> 01:57:10,036 CHILDREN OR CHILDREN NEED TO 3180 01:57:10,036 --> 01:57:12,372 ENGAGE WITH A FOSTER CARE SYSTEM 3181 01:57:12,372 --> 01:57:14,441 TO MAINTAIN THE FAMILIES WITHIN 3182 01:57:14,441 --> 01:57:18,278 THE STUDY, AS INVOLVED AS 3183 01:57:18,278 --> 01:57:18,545 POSSIBLE. 3184 01:57:18,545 --> 01:57:23,183 WORK GROUPS RELATED TO SOCIAL 3185 01:57:23,183 --> 01:57:23,817 AND ETHICAL OVERSIGHT INCLUDING 3186 01:57:23,817 --> 01:57:25,285 DIVERSITY, EQUITY, AND INCLUSION 3187 01:57:25,285 --> 01:57:30,190 AND FOCUSED ON BIOETHICS AS WELL 3188 01:57:30,190 --> 01:57:31,524 AS ETHICAL, LEGAL, POLICY ISSUES 3189 01:57:31,524 --> 01:57:35,662 THAT MAY COME TO PLAY WITHIN THE 3190 01:57:35,662 --> 01:57:35,962 HBCD STUDY. 3191 01:57:35,962 --> 01:57:37,430 FINALLY THERE'S A COHORT OF 3192 01:57:37,430 --> 01:57:39,265 COMMUNICATION GROUPS THAT FOCUS 3193 01:57:39,265 --> 01:57:41,234 ON COMMUNICATION BOTH WITHIN THE 3194 01:57:41,234 --> 01:57:42,235 STUDY AND TO EXTERNAL 3195 01:57:42,235 --> 01:57:46,539 STAKEHOLDERS AS WELL AS THE 3196 01:57:46,539 --> 01:57:48,274 GENERAL PUBLIC. 3197 01:57:48,274 --> 01:57:50,343 ALL THESE GROUPS COME TOGETHER 3198 01:57:50,343 --> 01:57:53,847 AND ARE ORGANIZED IN 3199 01:57:53,847 --> 01:57:56,382 COLLABORATION BETWEEN HCAC AND 3200 01:57:56,382 --> 01:57:57,784 HDCC TO INTEGRATE ANY ACTIVITIES 3201 01:57:57,784 --> 01:57:59,219 THAT REQUIRE MORE THAN ONE WORK 3202 01:57:59,219 --> 01:58:01,087 GROUP AND TRYING TO MAKE SURE 3203 01:58:01,087 --> 01:58:03,256 ALL WORK GROUPS ARE ENGAGING 3204 01:58:03,256 --> 01:58:04,157 TOGETHER AND INTERACTING. 3205 01:58:04,157 --> 01:58:05,658 IMPORTANTLY I WANT TO POINT OUT 3206 01:58:05,658 --> 01:58:08,161 THERE'S A WORK GROUP CO-CHAIRS 3207 01:58:08,161 --> 01:58:09,262 MEETING THAT HAPPENS BIWEEKLY 3208 01:58:09,262 --> 01:58:11,130 WHERE THE CO-CHAIRS OF EACH OF 3209 01:58:11,130 --> 01:58:12,165 THESE GROUPS COME TOGETHER AND 3210 01:58:12,165 --> 01:58:13,433 DISCUSS WHAT TOPICS THEY ARE 3211 01:58:13,433 --> 01:58:14,634 WORKING ON, WHAT ISSUES THEY 3212 01:58:14,634 --> 01:58:16,536 MIGHT BE FACING AND ARE THERE TO 3213 01:58:16,536 --> 01:58:17,470 PROVIDE FEEDBACK TO THE OTHER 3214 01:58:17,470 --> 01:58:18,137 WORKING GROUPS. 3215 01:58:18,137 --> 01:58:21,207 SO IT'S A VERY NICE AND 3216 01:58:21,207 --> 01:58:21,975 INTEGRATED STRUCTURE THAT REALLY 3217 01:58:21,975 --> 01:58:24,477 COMES FROM THE GROUND UP FROM 3218 01:58:24,477 --> 01:58:28,648 ALL THE INVESTIGATORS INVOLVED 3219 01:58:28,648 --> 01:58:29,516 IN THE STUDY. 3220 01:58:29,516 --> 01:58:38,258 YOU CAN SEE A SCHEMATIC OF THE 3221 01:58:38,258 --> 01:58:38,525 TIMELINE. 3222 01:58:38,525 --> 01:58:40,560 YOU CAN SEE IN-PERSON VISITS 3223 01:58:40,560 --> 01:58:47,901 PARTICIPANTS WILL BE ENGAGED IN, 3224 01:58:47,901 --> 01:58:48,635 STARTING PRENATAL THROUGH VISIT 3225 01:58:48,635 --> 01:58:51,170 6 UP TO 48 MONTHS OF LIFE. 3226 01:58:51,170 --> 01:58:52,705 IN ADDITION THREE REMOTE VISITS 3227 01:58:52,705 --> 01:58:54,140 WHERE ASSESSMENTS CAN BE DONE IN 3228 01:58:54,140 --> 01:58:58,177 THE HOME AND ON THE COMPUTER. 3229 01:58:58,177 --> 01:59:01,848 NEXT I'M GOING TO FOCUS ON THE 3230 01:59:01,848 --> 01:59:03,850 FIRST THREE VISITS OF THE STUDY 3231 01:59:03,850 --> 01:59:07,587 AS THESE HAVE BEEN FINALIZED AND 3232 01:59:07,587 --> 01:59:08,021 LAUNCHED. 3233 01:59:08,021 --> 01:59:10,189 WE'RE STILL WORKING ON 3234 01:59:10,189 --> 01:59:12,759 FINALIZING THE DATA COLLECTION 3235 01:59:12,759 --> 01:59:14,060 PROTOCOL FOR REMAINING VISITS. 3236 01:59:14,060 --> 01:59:16,362 SO HERE YOU CAN SEE THE 3237 01:59:16,362 --> 01:59:22,035 DIFFERENT ASPECTS OF THE 3238 01:59:22,035 --> 01:59:23,469 PRENATAL VISIT 1, INCLUDING 3239 01:59:23,469 --> 01:59:26,205 ASSESSMENTS OF MATERNAL OR BIRTH 3240 01:59:26,205 --> 01:59:28,274 PARENT HEALTH, AS WELL AS 3241 01:59:28,274 --> 01:59:30,143 COLLECTION OF BIOSPECIMENS AND 3242 01:59:30,143 --> 01:59:31,344 UNDERSTANDING OF CULTURE AND 3243 01:59:31,344 --> 01:59:34,514 ENVIRONMENT OF THE BIRTH PARENT. 3244 01:59:34,514 --> 01:59:36,716 SUBSTANCE USE IS ASSESSED 3245 01:59:36,716 --> 01:59:38,051 THROUGH TWO DIFFERENT 3246 01:59:38,051 --> 01:59:41,654 SELF-REPORT QUESTIONNAIRES 3247 01:59:41,654 --> 01:59:42,855 INCLUDING ASSIST AND TIMELINE 3248 01:59:42,855 --> 01:59:48,761 FOLLOW BACK AS WELL AS ASSAYS OF 3249 01:59:48,761 --> 01:59:50,730 BIOSPECIMENS, NAILS, SALIVA, 3250 01:59:50,730 --> 01:59:51,397 URINE. 3251 01:59:51,397 --> 01:59:53,032 VISIT 2 OCCURS BETWEEN 0 AND 1 3252 01:59:53,032 --> 01:59:54,767 MONTH OF AGE, WHAT I'M 3253 01:59:54,767 --> 01:59:55,735 HIGHLIGHTING HERE IN YELLOW 3254 01:59:55,735 --> 01:59:57,937 BOXES ARE ALL THE NEW CONSTRUCTS 3255 01:59:57,937 --> 01:59:58,838 AND MEASURES ADDED IN ADDITION 3256 01:59:58,838 --> 02:00:00,907 TO THE ONES THAT YOU'LL SEE IN 3257 02:00:00,907 --> 02:00:02,875 VISIT 1. 3258 02:00:02,875 --> 02:00:04,510 IMPORTANTLY THIS INCLUDES FIRST 3259 02:00:04,510 --> 02:00:07,380 MRI OF A BABY, AGAIN 0-1 MONTH, 3260 02:00:07,380 --> 02:00:07,914 VERY AMBITIOUS. 3261 02:00:07,914 --> 02:00:09,782 AND SO FAR GOING VERY NICELY. 3262 02:00:09,782 --> 02:00:11,651 I'LL SHOW YOU SOME INFORMATION 3263 02:00:11,651 --> 02:00:13,386 ABOUT THAT SOON. 3264 02:00:13,386 --> 02:00:16,889 AND ALSO USE OF MOBILE 3265 02:00:16,889 --> 02:00:18,424 TECHNOLOGY SUCH AS MOTION AND 3266 02:00:18,424 --> 02:00:20,293 HEART RATE SENSOR WHERE THE 3267 02:00:20,293 --> 02:00:21,494 CHILDREN WEAR THAT AT HOME FOR 3268 02:00:21,494 --> 02:00:24,797 72 HOURS SO WE CAN UNDERSTAND 3269 02:00:24,797 --> 02:00:26,099 SLEEP STATES AND AROUSAL. 3270 02:00:26,099 --> 02:00:28,735 WE'RE ALSO LOOKING AT NUTRITION 3271 02:00:28,735 --> 02:00:33,406 FACTORS, AND CHILD PHYSICAL 3272 02:00:33,406 --> 02:00:34,507 HEALTH AND GROWTH. 3273 02:00:34,507 --> 02:00:39,112 VISIT 3 WE'RE NOW ADDING IN THE 3274 02:00:39,112 --> 02:00:43,349 FIRST INFANT EEG SCAN AT 3 TO 9 3275 02:00:43,349 --> 02:00:45,251 MONTHS, MEASURES OF 3276 02:00:45,251 --> 02:00:47,553 NEUROCOGNITION, CHILD/CAREGIVER 3277 02:00:47,553 --> 02:00:48,721 INTERACTION, CHILD BEHAVIOR. 3278 02:00:48,721 --> 02:00:51,124 SO HERE'S AN UPDATE ON WHERE WE 3279 02:00:51,124 --> 02:00:59,232 ARE TODAY WITH THE HBCD STUDY, 3280 02:00:59,232 --> 02:01:01,401 WE'VE RECRUITED 1313 3281 02:01:01,401 --> 02:01:02,502 PARTICIPANTS, DATA FROM MAY 3282 02:01:02,502 --> 02:01:03,603 ENROLLMENT STARTING FROM THE 3283 02:01:03,603 --> 02:01:07,373 LAUNCH OF THE FIRST STUDY IN 3284 02:01:07,373 --> 02:01:11,811 JULY OF 2023, INCREASE THUS FAR. 3285 02:01:11,811 --> 02:01:15,081 THIS IS ACROSS ALL 27 SITES. 3286 02:01:15,081 --> 02:01:16,849 IN TERMS OF RACE AND ETHNICITY 3287 02:01:16,849 --> 02:01:20,553 OF THE SAMPLE, WE'RE AT 3288 02:01:20,553 --> 02:01:22,522 APPROXIMATELY 50% OF THE 3289 02:01:22,522 --> 02:01:24,824 PARTICIPANTS WHITE, 20% BLACK OR 3290 02:01:24,824 --> 02:01:28,127 AFRICAN AMERICAN, DIFFERENT 3291 02:01:28,127 --> 02:01:28,995 PORTIONS WITH ASIAN, AMERICAN 3292 02:01:28,995 --> 02:01:30,596 INDIAN/ALASKA NATIVE, AND TWO OR 3293 02:01:30,596 --> 02:01:31,798 MORE RACES. 3294 02:01:31,798 --> 02:01:36,302 ABOUT 18% OF OUR SAMPLE 3295 02:01:36,302 --> 02:01:37,503 IDENTIFIES AS HISPANIC OR 3296 02:01:37,503 --> 02:01:38,171 LATINO. 3297 02:01:38,171 --> 02:01:39,472 THIS GRAPH IS TRYING TO SHOW 3298 02:01:39,472 --> 02:01:41,541 WHAT THE SAMPLE LOOKS LIKE IN 3299 02:01:41,541 --> 02:01:43,643 TERMS OF PRENATAL SUBSTANCE USE. 3300 02:01:43,643 --> 02:01:45,712 THIS GRAPH IS SHOWING NOT ONLY 3301 02:01:45,712 --> 02:01:47,680 SUBSTANCE USE ITSELF BUT ALSO 3302 02:01:47,680 --> 02:01:49,449 POLY SUBSTANCE USE. 3303 02:01:49,449 --> 02:01:52,719 AND I'M SHOWING DATA HERE ACROSS 3304 02:01:52,719 --> 02:01:54,921 FOUR DIFFERENT CATEGORIES, ALL 3305 02:01:54,921 --> 02:01:56,556 LISTED HERE AS WELL. 3306 02:01:56,556 --> 02:01:58,958 SO IMPORTANTLY THESE DATA ARE 3307 02:01:58,958 --> 02:02:00,493 BASED ON SELF-REPORT MEASURES. 3308 02:02:00,493 --> 02:02:02,462 IT'S BASED ON FREQUENCY OF USE 3309 02:02:02,462 --> 02:02:05,398 OF EACH OF THESE FOUR 3310 02:02:05,398 --> 02:02:05,865 SUBSTANCES. 3311 02:02:05,865 --> 02:02:08,134 FIRST BEING OPIOIDS, OR 3312 02:02:08,134 --> 02:02:11,104 APPROXIMATELY 4% OF SAMPLE 3313 02:02:11,104 --> 02:02:13,072 REPORTED PRENATAL OPIOID USE. 3314 02:02:13,072 --> 02:02:16,909 11% REPORTED USE OF TOBACCO OR 3315 02:02:16,909 --> 02:02:17,176 NICOTINE. 3316 02:02:17,176 --> 02:02:19,512 12% REPORTED USE OF MARIJUANA OR 3317 02:02:19,512 --> 02:02:22,482 CANNABIS, 12% REPORTED ALCOHOL 3318 02:02:22,482 --> 02:02:22,682 USE. 3319 02:02:22,682 --> 02:02:25,551 THIS IS NOT ANY USE, THIS IS 3320 02:02:25,551 --> 02:02:26,219 AGAIN MEETING SPECIFIC 3321 02:02:26,219 --> 02:02:27,420 THRESHOLDS, SO THERE'S A LARGER 3322 02:02:27,420 --> 02:02:29,956 NUMBER OF FOLKS WHO HAVE 3323 02:02:29,956 --> 02:02:31,257 REPORTED ANY USE BUT THERE'S 3324 02:02:31,257 --> 02:02:33,426 REALLY FOCUS ON TRYING TO 3325 02:02:33,426 --> 02:02:35,962 IDENTIFY THOSE THAT MEET THESE 3326 02:02:35,962 --> 02:02:36,462 FREQUENCY THRESHOLDS. 3327 02:02:36,462 --> 02:02:38,464 I WANT TO POINT OUT HERE THAT 3328 02:02:38,464 --> 02:02:39,732 OUR CURRENT RATE OF SUBSTANCE 3329 02:02:39,732 --> 02:02:42,001 USE IN OUR POPULATION IS AT 25%. 3330 02:02:42,001 --> 02:02:44,303 WHICH IS RIGHT ON TARGET. 3331 02:02:44,303 --> 02:02:47,573 GOAL IS 25% OF THE POPULATION TO 3332 02:02:47,573 --> 02:02:49,642 HAVING BEEN EXPOSED TO 3333 02:02:49,642 --> 02:02:50,176 SUBSTANCES PRENATALLY. 3334 02:02:50,176 --> 02:02:53,146 I REALLY WANT TO COMMEND ALL 3335 02:02:53,146 --> 02:02:54,680 RESEARCH SITES TO FOCUSING ON 3336 02:02:54,680 --> 02:02:59,919 DIGGING INTO GETTING THESE HARD 3337 02:02:59,919 --> 02:03:00,920 TO REACH POPULATIONS TO ENROLL. 3338 02:03:00,920 --> 02:03:02,555 I WANT TO TALK ABOUT SOME OF THE 3339 02:03:02,555 --> 02:03:04,423 DATA THAT ARE BEING COLLECTED 3340 02:03:04,423 --> 02:03:05,391 BUT ONLY BRIEFLY BECAUSE WE'RE 3341 02:03:05,391 --> 02:03:07,794 STILL IN THE PROCESS OF GETTING 3342 02:03:07,794 --> 02:03:09,796 THE DATA, CLEANING DATA, BEING 3343 02:03:09,796 --> 02:03:13,666 ABLE TO RELEASE IT AT THE END OF 3344 02:03:13,666 --> 02:03:14,600 THE YEAR. 3345 02:03:14,600 --> 02:03:17,770 ONE OF OUR PRIMARY GOALS IS TO 3346 02:03:17,770 --> 02:03:18,437 UNDERSTAND TYPICAL 3347 02:03:18,437 --> 02:03:24,644 NEURODEVELOPMENT AND THE RANGE 3348 02:03:24,644 --> 02:03:26,746 OF VARIABILITY TO FOCUS ON 3349 02:03:26,746 --> 02:03:28,381 MULTI-MODAL ASSESSMENT. 3350 02:03:28,381 --> 02:03:33,085 FIRST SHOWING DIFFERENT TYPE OF 3351 02:03:33,085 --> 02:03:37,023 MRI SCANS WE COLLECT STARTING AT 3352 02:03:37,023 --> 02:03:39,859 VISIT 1, INCLUDING BRAIN 3353 02:03:39,859 --> 02:03:42,795 STRUCTURE, T1 AND T2, DIFFUSION 3354 02:03:42,795 --> 02:03:44,764 MRI QUANTITATIVE MRI. 3355 02:03:44,764 --> 02:03:47,500 WE HAVE TWO SCAN TYPES FOR BRAIN 3356 02:03:47,500 --> 02:03:51,270 FUNCTION, INCLUDING FUNCTIONAL 3357 02:03:51,270 --> 02:03:52,638 MRI AND MRI SPECTROSCOPY. 3358 02:03:52,638 --> 02:03:54,407 I'M GOING TO HIGHLIGHT QUALITY 3359 02:03:54,407 --> 02:03:56,776 OF THESE SCANS AND SHOWCASE 3360 02:03:56,776 --> 02:03:57,043 THEM. 3361 02:03:57,043 --> 02:03:59,645 THIS IS BRAIN IMAGE THAT IS 3362 02:03:59,645 --> 02:04:00,746 DERIVED DATA FROM FUNCTIONAL MRI 3363 02:04:00,746 --> 02:04:01,514 SCAN. 3364 02:04:01,514 --> 02:04:03,649 THIS IS A SAMPLE OF ONE. 3365 02:04:03,649 --> 02:04:06,219 A DATA FROM OUR FIRST HBCD STUDY 3366 02:04:06,219 --> 02:04:07,954 INFANT AT VISIT 1. 3367 02:04:07,954 --> 02:04:09,822 FOR THOSE FAMILIAR WITH 3368 02:04:09,822 --> 02:04:11,457 FUNCTIONAL BRAIN NETWORKS AND 3369 02:04:11,457 --> 02:04:13,192 FUNCTIONAL CONNECTIVITY, YOU CAN 3370 02:04:13,192 --> 02:04:15,661 SEE HERE THAT IN JUST ONE INFANT 3371 02:04:15,661 --> 02:04:19,465 WE WERE ABLE TO RECAPITULATE THE 3372 02:04:19,465 --> 02:04:21,000 DEFAULT MODE NETWORK WITH THE 3373 02:04:21,000 --> 02:04:25,605 SCANS THAT ARE ACQUIRED IN THE 3374 02:04:25,605 --> 02:04:27,473 STUDY. 3375 02:04:27,473 --> 02:04:30,076 WE'RE ALSO COLLECTING EEG DATA 3376 02:04:30,076 --> 02:04:31,277 ACROSS FOUR DOMAINS, INCLUDING 3377 02:04:31,277 --> 02:04:36,315 RESTING STATE, RESPONSES TO 3378 02:04:36,315 --> 02:04:40,920 FACES, VISUAL EVOKED POTENTIAL, 3379 02:04:40,920 --> 02:04:41,320 AUDITORY ODDBALL. 3380 02:04:41,320 --> 02:04:43,189 NEXT I WOULD LIKE TO PASS THE 3381 02:04:43,189 --> 02:04:46,726 MIC OVER TO CHLOE JORDAN, AGAIN 3382 02:04:46,726 --> 02:04:47,827 JOINING VIRTUALLY, HOPEFULLY SHE 3383 02:04:47,827 --> 02:04:49,061 CAN COME OFF CAMERA. 3384 02:04:49,061 --> 02:04:52,298 I SEE HER RIGHT HERE. 3385 02:04:52,298 --> 02:04:54,100 >> HI, EVERYONE. 3386 02:04:54,100 --> 02:04:54,967 THANK YOU, KATHY. 3387 02:04:54,967 --> 02:04:56,402 HOPEFULLY YOU CAN HEAR MY. 3388 02:04:56,402 --> 02:04:58,671 I'M SORRY I'M NOT THERE IN 3389 02:04:58,671 --> 02:04:59,005 PERSON. 3390 02:04:59,005 --> 02:05:01,874 SO AS YOU SAW EARLIER WE'RE 3391 02:05:01,874 --> 02:05:03,943 ASSESSING SUBSTANCE USE IN TWO 3392 02:05:03,943 --> 02:05:05,478 WAYS, ONE THROUGH SELF-REPORT, 3393 02:05:05,478 --> 02:05:09,282 THE OTHER THROUGH COLLECTION OF 3394 02:05:09,282 --> 02:05:10,816 BIOSPECIMENS. 3395 02:05:10,816 --> 02:05:12,919 IN TERMS OF SELF-REPORT, FIRST 3396 02:05:12,919 --> 02:05:16,989 ALCOHOL, SMOKING, SUBSTANCE 3397 02:05:16,989 --> 02:05:18,758 SCREENING TEST, THIS IS GIVEN 3398 02:05:18,758 --> 02:05:23,496 DURING VISIT 1 AS LIFETIME USE 3399 02:05:23,496 --> 02:05:24,830 SCREENING SECTION, PARTICIPANTS 3400 02:05:24,830 --> 02:05:27,333 ASKED HAVE YOU USED ANY OF THESE 3401 02:05:27,333 --> 02:05:28,100 INCLUDING PRESCRIPTION 3402 02:05:28,100 --> 02:05:29,101 MEDICATION IF THEY ENDORSE USE 3403 02:05:29,101 --> 02:05:32,571 YOU FOLLOW UP WITH TIMELINE TO 3404 02:05:32,571 --> 02:05:33,906 GET SPECIFIC SNAPSHOTS OF WHEN 3405 02:05:33,906 --> 02:05:36,742 THIS IS OCCURRING DURING AND 3406 02:05:36,742 --> 02:05:43,749 AFTER PREGNANCY. 3407 02:05:43,749 --> 02:05:45,384 SO ENDORSEMENT OPENS FOLLOW 3408 02:05:45,384 --> 02:05:52,191 BACK, ONE IS ROUTINE, SO ANY 3409 02:05:52,191 --> 02:05:55,127 SUBSTANCES TAKEN DAILY, 3410 02:05:55,127 --> 02:05:57,229 CIGARETTES, OFTEN VAPING. 3411 02:05:57,229 --> 02:05:58,864 THEN FOLLOW BACK PRE-LAST 3412 02:05:58,864 --> 02:05:59,632 MENSTRUAL PERIOD, TWO WEEKS 3413 02:05:59,632 --> 02:06:01,734 PRIOR TO THE LAST MENSTRUAL 3414 02:06:01,734 --> 02:06:03,235 PERIOD BEFORE PREGNANCY, AS WELL 3415 02:06:03,235 --> 02:06:07,173 AS FOUR WEEKS POST LAST 3416 02:06:07,173 --> 02:06:07,606 MENSTRUAL PERIOD. 3417 02:06:07,606 --> 02:06:09,241 AND SUBSTANCE ABUSE IN 7 DAYS 3418 02:06:09,241 --> 02:06:14,146 PRIOR TO VISIT 1, OCCURRING 3419 02:06:14,146 --> 02:06:17,016 GENERALLY DURING THE SECOND 3420 02:06:17,016 --> 02:06:17,783 TRIMESTER, GIVING A SNAPSHOT 3421 02:06:17,783 --> 02:06:19,218 DURING AND JUST BEFORE 3422 02:06:19,218 --> 02:06:19,852 PREGNANCY. 3423 02:06:19,852 --> 02:06:21,620 THE OTHER WAY WE ASSESS 3424 02:06:21,620 --> 02:06:22,722 SUBSTANCE EXPOSURE IS AGAIN 3425 02:06:22,722 --> 02:06:25,624 THROUGH COLLECTION OF 3426 02:06:25,624 --> 02:06:27,093 BIOSPECIMENS, NEXT SLIDE. THAT 3427 02:06:27,093 --> 02:06:30,596 WILL SHOW SNAPSHOT TABLE OF THE 3428 02:06:30,596 --> 02:06:41,007 BIOSAMPLING TIMELINE FOR EACH 3429 02:06:41,007 --> 02:06:41,841 VISIT. 3430 02:06:41,841 --> 02:06:44,710 VISIT 1 PRENATAL COLLECT NAILS, 3431 02:06:44,710 --> 02:06:49,615 AS WELL AS BLOOD, SEPARATED INTO 3432 02:06:49,615 --> 02:06:51,050 SERUM, PLASMA, WHOLE BLOOD, 3433 02:06:51,050 --> 02:06:52,585 URINE FROM BIRTH PARENT, AFTER 3434 02:06:52,585 --> 02:06:55,554 BIRTH AND VISIT 2 AGAIN DURING 3435 02:06:55,554 --> 02:06:56,989 THE FIRST MONTH POST-BIRTH WE 3436 02:06:56,989 --> 02:06:59,925 COLLECT NAILS FROM BIRTH PARENT, 3437 02:06:59,925 --> 02:07:01,694 URINE, STOOL, SALIVA FROM THE 3438 02:07:01,694 --> 02:07:03,195 CHILD. 3439 02:07:03,195 --> 02:07:04,530 VISIT 3 AND THEREAFTER URINE, 3440 02:07:04,530 --> 02:07:05,965 STOOL, SALIVA FROM THE CHILD, 3441 02:07:05,965 --> 02:07:08,434 NOTHING REPEATED IN THE BIRTH 3442 02:07:08,434 --> 02:07:10,636 PARENT UNTIL VISIT 6 WHEN SALIVA 3443 02:07:10,636 --> 02:07:12,738 IS COLLECTED AGAIN. 3444 02:07:12,738 --> 02:07:14,907 CURRENTLY NAILS FROM VISIT 2 AS 3445 02:07:14,907 --> 02:07:16,842 WELL AS DRY BLOODSPOT CARDS AND 3446 02:07:16,842 --> 02:07:20,379 URINE ARE SHIPPED TO THE 3447 02:07:20,379 --> 02:07:22,448 LABORATORY FOR ANALYSIS FOR 3448 02:07:22,448 --> 02:07:25,951 SUBSTANCE USE, AND REMAINING 3449 02:07:25,951 --> 02:07:26,719 ASSESSMENTS SHIPPED TO 3450 02:07:26,719 --> 02:07:27,820 BIOREPOSITORY FOR STORAGE AND 3451 02:07:27,820 --> 02:07:33,192 FUTURE USE BY OTHER 3452 02:07:33,192 --> 02:07:36,562 INVESTIGATORS. 3453 02:07:36,562 --> 02:07:37,563 SAMPLE EXTRACTING DNA, SITES 3454 02:07:37,563 --> 02:07:40,066 STORING WE HOPE FOR ANALYSIS IN 3455 02:07:40,066 --> 02:07:41,600 THE NEAR FUTURE. 3456 02:07:41,600 --> 02:07:43,803 NEXT SLIDE SHOWS PRELIMINARY 3457 02:07:43,803 --> 02:07:45,004 SNAPSHOT OF PRELIMINARY RESULTS 3458 02:07:45,004 --> 02:07:47,606 FROM U.S. DETAIL ANALYSES OF 3459 02:07:47,606 --> 02:07:49,475 SUBSTANCE EXPOSURE FOCUSING ON 3460 02:07:49,475 --> 02:07:52,645 URINE AND DRIED BLOODSPOT CARDS, 3461 02:07:52,645 --> 02:07:53,746 PRELIMINARY RESULTS AGAIN PULLED 3462 02:07:53,746 --> 02:07:55,514 AS OF MAY 1 SO WE'RE STILL 3463 02:07:55,514 --> 02:07:57,249 COLLECTING A LOT OF DATA, 3464 02:07:57,249 --> 02:07:59,952 SUBJECT TO CHANGE, BUT JUST TO 3465 02:07:59,952 --> 02:08:01,720 GIVE A SNEAK PREVIEW OF WHAT'S 3466 02:08:01,720 --> 02:08:04,223 GOING ON LEFT PANELS SHOWING 3467 02:08:04,223 --> 02:08:06,859 URINE ANALYSIS FROM VISIT 1, 3468 02:08:06,859 --> 02:08:11,130 RIGHT PANELS SHOWING VISIT 1 3469 02:08:11,130 --> 02:08:16,068 RESULTS OF ANALYSIS OF PETH. 3470 02:08:16,068 --> 02:08:17,937 DETECTION WINDOW IS TWO TO FOUR 3471 02:08:17,937 --> 02:08:20,439 WEEKS, COLLECTED AT VISIT 1, 3472 02:08:20,439 --> 02:08:24,176 GIVING US A LOOK BACK FROM WHEN 3473 02:08:24,176 --> 02:08:28,981 VISIT 1 OCCURRED, THIS CHART 3474 02:08:28,981 --> 02:08:36,956 SHOWS 82% ARE NEGATIVE FOR PETH, 3475 02:08:36,956 --> 02:08:37,857 18% POSITIVE. 3476 02:08:37,857 --> 02:08:42,595 THIS IS HIGHER THAN 12% IN 3477 02:08:42,595 --> 02:08:45,865 SELF-REPORT, BASED ON TIMELINE. 3478 02:08:45,865 --> 02:08:48,134 NOTING TEST DOES NOT DETECT 3479 02:08:48,134 --> 02:08:49,368 LIGHT OR CASUAL DRINKING, ONE 3480 02:08:49,368 --> 02:08:50,236 DRINK WOULD NOT NECESSARILY 3481 02:08:50,236 --> 02:08:51,770 RESULT IN A POSITIVE TEST BUT 3482 02:08:51,770 --> 02:08:54,340 THERE'S A LOT OF INDIVIDUAL 3483 02:08:54,340 --> 02:08:59,845 DIFFERENCES IN HOW MUCH 3484 02:08:59,845 --> 02:09:01,147 COLLABORATIVE IS NECESSARY, THIS 3485 02:09:01,147 --> 02:09:02,915 VARIES AMONG PEOPLE THAT ARE 3486 02:09:02,915 --> 02:09:03,782 PREGNANT AND HAVE INCREASING 3487 02:09:03,782 --> 02:09:04,483 BLOOD VOLUME. 3488 02:09:04,483 --> 02:09:07,186 URINE AGAIN IS SHOWN ON THE LEFT 3489 02:09:07,186 --> 02:09:09,688 PANEL, DETECTION WINDOWS ARE 3490 02:09:09,688 --> 02:09:13,092 SHORTER THAN PETH ANNUAL IS, 2 3491 02:09:13,092 --> 02:09:17,796 TO 4 DAYS, WITH THE EXCEPTION OF 3492 02:09:17,796 --> 02:09:20,966 CANNABINOIDS THAT CAN DETECTS 3493 02:09:20,966 --> 02:09:25,938 FOR AS MANY AS 30 DAYS IN PEOPLE 3494 02:09:25,938 --> 02:09:27,473 THAT USE FREQUENTLY. 3495 02:09:27,473 --> 02:09:28,974 AGAIN THIS VARIES FROM PERSON TO 3496 02:09:28,974 --> 02:09:31,510 PERSON, MAY BE FURTHER IMPACTED 3497 02:09:31,510 --> 02:09:33,812 BY PREGNANCY. 3498 02:09:33,812 --> 02:09:36,549 URINE SUBSTANCES COUNTED AS 3499 02:09:36,549 --> 02:09:38,651 POSITIVE, ON INITIAL TEST AS 3500 02:09:38,651 --> 02:09:39,818 WELL AS SECONDARY CONFIRMATION 3501 02:09:39,818 --> 02:09:43,122 TEST, TO HELP US REDUCE RISK OF 3502 02:09:43,122 --> 02:09:43,889 FALSE POSITIVES HAPPENING. 3503 02:09:43,889 --> 02:09:46,292 TOP PANEL ON THE LEFT SHOWS 3504 02:09:46,292 --> 02:09:49,361 PERCENTAGE OF TOTAL SPECIMENS 3505 02:09:49,361 --> 02:09:51,430 ANALYZED, 753 SO FAR, POSITIVE 3506 02:09:51,430 --> 02:09:52,398 FOR EACH SUBSTANCE. 3507 02:09:52,398 --> 02:09:54,066 NOT SHOWING ALL OF THE 3508 02:09:54,066 --> 02:09:58,337 SUBSTANCES HERE, WE ALSO TEST 3509 02:09:58,337 --> 02:10:02,274 FOR KETAMINE, MUSCLE RELAXANTS, 3510 02:10:02,274 --> 02:10:03,642 SEDATIVES, OTHERS ARE NICOTINE 3511 02:10:03,642 --> 02:10:04,810 AND CANNABINOIDS. 3512 02:10:04,810 --> 02:10:06,545 ON THE LEFT SHOWS EXACT NUMBER 3513 02:10:06,545 --> 02:10:08,714 OF POSITIVE URINE SPECIMENS OF 3514 02:10:08,714 --> 02:10:10,482 THESE, BOTH GRAPH AND TABLE ARE 3515 02:10:10,482 --> 02:10:20,993 GROUPS BY SUBSTANCE SO WE HAVE 3516 02:10:20,993 --> 02:10:21,594 ALCOHOL, BENZOS, BARBITURATES, 3517 02:10:21,594 --> 02:10:23,295 NICOTINE, COULD BE USED FOR 3518 02:10:23,295 --> 02:10:24,597 MEDICATION, GROUPS ARE STILL 3519 02:10:24,597 --> 02:10:26,031 WORKING ON MATCHING DATA TO THE 3520 02:10:26,031 --> 02:10:28,367 SELF-REPORT DATA ON THE TIMELINE 3521 02:10:28,367 --> 02:10:29,702 CALLBACK, SEEING OVERLAP BETWEEN 3522 02:10:29,702 --> 02:10:30,903 THE TWO. 3523 02:10:30,903 --> 02:10:32,972 BUT OVERALL OPIOID POSITIVE 3524 02:10:32,972 --> 02:10:36,675 SPECIMENS ADD UP TO 4.8% AND 3525 02:10:36,675 --> 02:10:40,112 THAT CLOSELY APPROXIMATES 4% 3526 02:10:40,112 --> 02:10:42,748 POSITIVE MEETING TIMELINE FOLLOW 3527 02:10:42,748 --> 02:10:46,018 BACK SHOWN EARLIER. 3528 02:10:46,018 --> 02:10:47,353 NICOTINE ALSO CLOSE, 11.4% 3529 02:10:47,353 --> 02:10:49,521 ASSESSMENT SO FAR POSITIVE FOR 3530 02:10:49,521 --> 02:10:53,158 NICOTINE, AND ABOUT 11% OF 3531 02:10:53,158 --> 02:10:56,095 PEOPLE IN SELF-REPORTED USE 3532 02:10:56,095 --> 02:10:56,629 CRITERIA. 3533 02:10:56,629 --> 02:11:00,933 CANNABIS IS LOWER, 9% SO FAR 3534 02:11:00,933 --> 02:11:02,668 POSITIVE, 12% OF PARTICIPANTS 3535 02:11:02,668 --> 02:11:04,203 MET SELF-REPORT CRITERIA. 3536 02:11:04,203 --> 02:11:05,537 AS YOU CAN SEE ALCOHOL 3537 02:11:05,537 --> 02:11:07,573 PROTECTION IN URINE HAS BEEN 3538 02:11:07,573 --> 02:11:09,541 QUITE LOW, WE SUSPECT MAYBE 3539 02:11:09,541 --> 02:11:11,443 BECAUSE OF SHORTER DETECTION 3540 02:11:11,443 --> 02:11:14,480 WINDOW, AGAIN 2 TO 4 DAYS 3541 02:11:14,480 --> 02:11:19,818 COMPARED TO WEEKS IN THE DRIED 3542 02:11:19,818 --> 02:11:28,694 BLOODSPOT CARDS. 3543 02:11:28,694 --> 02:11:30,229 I'LL PASS TO JANANI. 3544 02:11:30,229 --> 02:11:31,864 >> THANKS, WE WANTED TO END OUR 3545 02:11:31,864 --> 02:11:33,732 PRESENTATION BY TALKING ABOUT 3546 02:11:33,732 --> 02:11:37,202 OUR RESULTS BASED ACCOUNTABILITY 3547 02:11:37,202 --> 02:11:38,404 APPROACH. 3548 02:11:38,404 --> 02:11:39,738 THIS REFLECTS THE MONITORING 3549 02:11:39,738 --> 02:11:40,005 APPROACH. 3550 02:11:40,005 --> 02:11:43,575 WE DO THIS BY USING REALTIME 3551 02:11:43,575 --> 02:11:45,644 DATA FROM MULTIPLE SOURCES TO 3552 02:11:45,644 --> 02:11:48,380 ENSURE WE MEET OUR STUDY 3553 02:11:48,380 --> 02:11:49,915 OBJECTIVES AS A CONSORTIUM. 3554 02:11:49,915 --> 02:11:52,551 SO, ONE OF THE WAYS WE DO THAT 3555 02:11:52,551 --> 02:11:52,685 -- 3556 02:11:52,685 --> 02:11:58,657 >> I HAVE A QUESTION. 3557 02:11:58,657 --> 02:12:00,926 HAS THIS PATIENT HAD ANYTHING 3558 02:12:00,926 --> 02:12:04,697 THAT FLAGS G-12 C AND ARE YOU 3559 02:12:04,697 --> 02:12:08,834 TREATING ON A RAS INHIBITORS? 3560 02:12:08,834 --> 02:12:09,635 NO? 3561 02:12:09,635 --> 02:12:11,270 OKAY. 3562 02:12:11,270 --> 02:12:12,905 >> PLEASE MUTE. 3563 02:12:12,905 --> 02:12:15,207 >> METASTATIC, OKAY. 3564 02:12:15,207 --> 02:12:15,607 >> PLEASE MUTE. 3565 02:12:15,607 --> 02:12:18,477 >> I THINK WE'RE MUTED. 3566 02:12:18,477 --> 02:12:18,811 ALL RIGHT. 3567 02:12:18,811 --> 02:12:20,479 SO, YEAH, GOING BACK, ONE OF THE 3568 02:12:20,479 --> 02:12:23,615 WAYS IN WHICH WE APPROACH OUR 3569 02:12:23,615 --> 02:12:25,284 MONITORING IS THROUGH THE METRIC 3570 02:12:25,284 --> 02:12:27,486 MONITORING WORK GROUP, RECENTLY 3571 02:12:27,486 --> 02:12:27,853 ESTABLISHED. 3572 02:12:27,853 --> 02:12:30,556 THIS WORK GROUP HAS A CHARGE TO 3573 02:12:30,556 --> 02:12:32,491 MONITOR SITE PROGRESS, AND 3574 02:12:32,491 --> 02:12:33,392 REALLY UNDERSTAND SITE CAPACITY 3575 02:12:33,392 --> 02:12:35,227 SO WORK WITH OUR INVESTIGATORS 3576 02:12:35,227 --> 02:12:36,995 AND OUR SITES TO UNDERSTAND WHAT 3577 02:12:36,995 --> 02:12:39,198 IS WORKING, WHAT ARE THE 3578 02:12:39,198 --> 02:12:40,833 CHALLENGES, AND WHAT CAN WE DO 3579 02:12:40,833 --> 02:12:44,636 TO HELP THEM AND REALLY 3580 02:12:44,636 --> 02:12:45,971 IMPORTANTLY SUGGEST REALISTIC 3581 02:12:45,971 --> 02:12:47,272 EXPECTATIONS FOR STUDY PROGRESS 3582 02:12:47,272 --> 02:12:48,907 OR MONITORING OF STUDY PROGRESS. 3583 02:12:48,907 --> 02:12:50,476 AND THIS WORKING GROUP WORKS 3584 02:12:50,476 --> 02:12:52,978 DIRECTLY WITH SITES THAT ARE 3585 02:12:52,978 --> 02:12:55,481 LAGGING BEHIND AND FACING 3586 02:12:55,481 --> 02:12:58,016 CHALLENGES, IN ORDER TO 3587 02:12:58,016 --> 02:12:59,451 ESTABLISH STRATEGIES AND PROVIDE 3588 02:12:59,451 --> 02:13:03,155 RESOURCES TO HELP THEM CATCH UP. 3589 02:13:03,155 --> 02:13:05,357 SO NIH'S PARTICIPATION ALLOWS US 3590 02:13:05,357 --> 02:13:06,425 TO WORK IN COLLABORATION WITH 3591 02:13:06,425 --> 02:13:08,861 MEMBERS OF THE WORKING GROUP AND 3592 02:13:08,861 --> 02:13:11,630 SITES TO ENSURE WE MEET OUR 3593 02:13:11,630 --> 02:13:11,930 OBJECTIVES. 3594 02:13:11,930 --> 02:13:13,732 AND I WOULD LIKE TO INTRODUCE 3595 02:13:13,732 --> 02:13:24,243 OUR CO-CHAIRS OF THIS WORKING 3596 02:13:26,011 --> 02:13:29,081 GROUP, DR. ALTHOFF, JERNIGAN, 3597 02:13:29,081 --> 02:13:32,317 AND DR. BRENDA JONES HARDEN WITH 3598 02:13:32,317 --> 02:13:33,185 OVERSIGHT IN GENERAL. 3599 02:13:33,185 --> 02:13:35,254 ONE WAY WE'RE ABLE TO MONITOR 3600 02:13:35,254 --> 02:13:36,922 SITE PROGRESS IS THROUGH OUR 3601 02:13:36,922 --> 02:13:37,222 DASHBOARDS. 3602 02:13:37,222 --> 02:13:40,125 SO WE HAVE TWO DASHBOARDS, ONE 3603 02:13:40,125 --> 02:13:42,628 IS THE ENROLLMENT DASHBOARD, AND 3604 02:13:42,628 --> 02:13:44,830 THIS IN REAL TIME PROVIDES US 3605 02:13:44,830 --> 02:13:46,698 THE TOTAL NUMBER OF ENROLLED 3606 02:13:46,698 --> 02:13:49,535 PARTICIPANTS IN OUR STUDY. 3607 02:13:49,535 --> 02:13:50,436 IT SHOWS ENROLLMENT PROGRESS 3608 02:13:50,436 --> 02:13:54,907 TOWARDS SEVERAL GOALS THAT WE 3609 02:13:54,907 --> 02:13:56,208 HAVE INCLUDING TRACKING OF THE 3610 02:13:56,208 --> 02:13:58,844 NUMBER OF PARTICIPANTS WHO USE 3611 02:13:58,844 --> 02:14:01,380 SUBSTANCES, AND ACROSS OTHER 3612 02:14:01,380 --> 02:14:02,381 PARTICIPANT CHARACTERISTICS AS 3613 02:14:02,381 --> 02:14:02,581 WELL. 3614 02:14:02,581 --> 02:14:04,416 THIS IS UPDATED IN REAL TIME AS 3615 02:14:04,416 --> 02:14:07,052 I SAID, ALLOWS US TO TRACK HOW 3616 02:14:07,052 --> 02:14:08,720 SUCCESSFUL WE ARE AND WHERE WE 3617 02:14:08,720 --> 02:14:10,989 NEED TO MAKE CHANGES. 3618 02:14:10,989 --> 02:14:12,090 ONE COOL THING ABOUT THIS 3619 02:14:12,090 --> 02:14:15,894 DASHBOARD IS THAT IT ALLOWS 3620 02:14:15,894 --> 02:14:20,399 US -- ALLOWS SITES TO TITRATE 3621 02:14:20,399 --> 02:14:25,204 RATES OF ENROLLMENT, TO PROJECT 3622 02:14:25,204 --> 02:14:26,772 FORWARD AND BE FORWARD PLANNING, 3623 02:14:26,772 --> 02:14:27,973 IF YOU CHANGE NEXT WEEK OR 3624 02:14:27,973 --> 02:14:28,740 SEVERAL YEARS FROM NOW WHERE 3625 02:14:28,740 --> 02:14:31,143 DOES THAT TAKE US TO OUR END 3626 02:14:31,143 --> 02:14:34,646 GOAL IN THE OTHER DASHBOARD IS 3627 02:14:34,646 --> 02:14:36,315 METRICS DAB BOARD, SHOWING 3628 02:14:36,315 --> 02:14:37,950 COMPLETION OF STUDY MEASURES AND 3629 02:14:37,950 --> 02:14:38,617 STUDY VISITS. 3630 02:14:38,617 --> 02:14:41,520 THIS ALLOWS US TO HAVE A CLEAR 3631 02:14:41,520 --> 02:14:44,623 MEASURE OF OUR STUDY OR VISIT 3632 02:14:44,623 --> 02:14:45,791 BURDEN AND MAKE CHANGES. 3633 02:14:45,791 --> 02:14:48,093 SO TAKING ALL OF THESE 3634 02:14:48,093 --> 02:14:50,929 APPROACHES TOGETHER ALLOWS US TO 3635 02:14:50,929 --> 02:14:52,030 BE FLEXIBLE AND NIMBLE IN TERMS 3636 02:14:52,030 --> 02:14:54,099 OF WHAT WE NEED TO BE ABLE TO DO 3637 02:14:54,099 --> 02:14:56,001 AT ANY GIVEN POINT TO MEET OUR 3638 02:14:56,001 --> 02:14:59,638 GOALS AND ALSO ALLOWS US TO SET 3639 02:14:59,638 --> 02:15:02,007 REALISTIC EXPECTATIONS THAT ARE 3640 02:15:02,007 --> 02:15:04,209 ACHIEVABLE AT THE END OF THE 3641 02:15:04,209 --> 02:15:04,743 DAY. 3642 02:15:04,743 --> 02:15:05,944 THAT CONCLUDES OUR PRESENTATION 3643 02:15:05,944 --> 02:15:16,488 AND WE ARE HERE FOR QUESTIONS. 3644 02:15:19,391 --> 02:15:21,493 >> DO WE HAVE TIME FOR SIX? 3645 02:15:21,493 --> 02:15:23,262 >> SIX MINUTES FOR QUESTIONS, 3646 02:15:23,262 --> 02:15:25,097 MORE TIME AT THE TIME OF 3647 02:15:25,097 --> 02:15:25,430 DISCUSSION. 3648 02:15:25,430 --> 02:15:27,699 PLEASE. 3649 02:15:27,699 --> 02:15:32,971 3650 02:15:32,971 --> 02:15:35,374 >> THANK YOU. 3651 02:15:35,374 --> 02:15:36,808 THIS IS VERY EXCITING. 3652 02:15:36,808 --> 02:15:40,312 I HAVE TO SAY THAT EVEN IN THIS 3653 02:15:40,312 --> 02:15:43,815 EARLY PHASE THAT THE POSITIVE 3654 02:15:43,815 --> 02:15:46,118 URINES ARE PRETTY DRAMATIC FOR 3655 02:15:46,118 --> 02:15:46,752 PREGNANT WOMEN. 3656 02:15:46,752 --> 02:15:49,154 I WANT TO ACKNOWLEDGE THAT, WITH 3657 02:15:49,154 --> 02:15:53,225 THE DRIED SPOT VERSUS THE URINE 3658 02:15:53,225 --> 02:15:55,394 ALCOHOL LEVEL, THE LEVELS, NOT 3659 02:15:55,394 --> 02:15:57,129 SURPRISING AS GEORGE SHOWED, BUT 3660 02:15:57,129 --> 02:15:59,131 CANNABIS LEVELS BEING THAT HIGH 3661 02:15:59,131 --> 02:16:01,533 AND THAT'S BEEN SHOWN ALSO THE 3662 02:16:01,533 --> 02:16:03,402 BIG KAISER STUDY AND THINGS. 3663 02:16:03,402 --> 02:16:06,572 AND I GUESS PART OF ME JUST 3664 02:16:06,572 --> 02:16:12,811 WONDERING WHETHER THERE IS A 3665 02:16:12,811 --> 02:16:14,446 RESPONSIBILITY OR SOME EDUCATION 3666 02:16:14,446 --> 02:16:15,414 INFORMATION IMPARTING OF THAT 3667 02:16:15,414 --> 02:16:17,616 GOING ON TO THE MOTHER, TO THE 3668 02:16:17,616 --> 02:16:20,852 PREGNANT WOMEN HERE, BECAUSE IT 3669 02:16:20,852 --> 02:16:23,622 JUST FEELS LIKE THIS IS HIGH 3670 02:16:23,622 --> 02:16:25,490 NUMBERS AND OF COURSE WE OUR 3671 02:16:25,490 --> 02:16:27,359 GOAL IS TO FIND OUT AND DEVELOP, 3672 02:16:27,359 --> 02:16:29,995 YOU DON'T WANT TO MESS WITH 3673 02:16:29,995 --> 02:16:31,196 THAT, BUT THERE'S A 3674 02:16:31,196 --> 02:16:32,397 RESPONSIBILITY HERE, THAT I 3675 02:16:32,397 --> 02:16:33,465 WANTED TO SEE HOW YOU'RE 3676 02:16:33,465 --> 02:16:33,765 ADDRESSING. 3677 02:16:33,765 --> 02:16:37,069 >> THANK YOU VERY MUCH FOR THAT 3678 02:16:37,069 --> 02:16:37,536 QUESTION. 3679 02:16:37,536 --> 02:16:39,404 I THINK THE CONSORTIUM HAD A BIG 3680 02:16:39,404 --> 02:16:44,309 DISCUSSION ABOUT WHAT TYPE OF 3681 02:16:44,309 --> 02:16:46,178 RESOURCES WE WANT TO PROVIDE TO 3682 02:16:46,178 --> 02:16:48,013 MAKE SURE WE'RE INFORMATIVE BUT 3683 02:16:48,013 --> 02:16:51,950 NOT BEING INTERVENTIONAL. 3684 02:16:51,950 --> 02:16:54,252 WE DECIDED TO CREATE A FLYER, 3685 02:16:54,252 --> 02:16:55,320 PREGNANCY HEALTHS FLYER THAT HAS 3686 02:16:55,320 --> 02:16:57,756 A LOT OF INFORMATION THAN 3687 02:16:57,756 --> 02:16:59,291 INCLUSIVE OF SUBSTANCE USE 3688 02:16:59,291 --> 02:17:00,492 DURING PREGNANCY. 3689 02:17:00,492 --> 02:17:02,728 AND SOME RISKS. 3690 02:17:02,728 --> 02:17:04,630 AS WELL AS CREATING AN 3691 02:17:04,630 --> 02:17:07,299 ASSOCIATED WEB PAGE SO THAT 3692 02:17:07,299 --> 02:17:08,400 PARTICIPANTS CAN VIEW IT AS A 3693 02:17:08,400 --> 02:17:10,402 FLYER OR ON A WEB PAGE. 3694 02:17:10,402 --> 02:17:12,237 AND INFORMATION FOR THESE IS 3695 02:17:12,237 --> 02:17:14,139 REALLY TAKEN FROM A LOT OF 3696 02:17:14,139 --> 02:17:15,774 DIFFERENT NATIONAL RESOURCES, 3697 02:17:15,774 --> 02:17:18,276 IT'S NOT SPECIFIC OR TARGETED TO 3698 02:17:18,276 --> 02:17:20,412 OUR POPULATION BUT IS POINTING 3699 02:17:20,412 --> 02:17:21,847 THEM TO ADDITIONAL RESOURCES. 3700 02:17:21,847 --> 02:17:24,950 I THINK ONE OF THE CONCERNS WAS 3701 02:17:24,950 --> 02:17:26,918 WANTING TO RECRUIT PARTICIPANTS 3702 02:17:26,918 --> 02:17:29,087 AND HAVING THEM BE HONEST ABOUT 3703 02:17:29,087 --> 02:17:31,390 THEIR SUBSTANCE USE, AND IN NO 3704 02:17:31,390 --> 02:17:33,825 WAY STIGMATIZING THEM OR THAT 3705 02:17:33,825 --> 02:17:36,094 SUBSTANCE USE, BUT STILL BEING 3706 02:17:36,094 --> 02:17:36,428 INFORMATIVE. 3707 02:17:36,428 --> 02:17:38,063 SO I THINK THROUGH MANY 3708 02:17:38,063 --> 02:17:38,964 DISCUSSIONS THAT WENT THROUGH 3709 02:17:38,964 --> 02:17:40,032 MANY OF THE DIFFERENT WORK 3710 02:17:40,032 --> 02:17:41,933 GROUPS I THINK THAT'S HOW WE 3711 02:17:41,933 --> 02:17:44,770 DECIDED TO THREAD THE NEEDLE, 3712 02:17:44,770 --> 02:17:47,639 INFORMING BUT TRYING NOT TO 3713 02:17:47,639 --> 02:17:50,776 STIGMATIZE. 3714 02:17:50,776 --> 02:17:52,411 >> I'M SORRY IF I MISSED THIS, 3715 02:17:52,411 --> 02:17:54,946 CAN YOU TELL ME IF YOU'RE 3716 02:17:54,946 --> 02:17:55,681 DISTINGUISHING BETWEEN METHADONE 3717 02:17:55,681 --> 02:17:58,884 THAT'S PRESCRIBED FOR PAIN 3718 02:17:58,884 --> 02:18:01,086 VERSUS METHADONE FOR TREATMENT 3719 02:18:01,086 --> 02:18:03,255 DISORDER AND IN YOUR OPIOID 3720 02:18:03,255 --> 02:18:06,858 SECTION IF YOU'RE SEPARATING OUT 3721 02:18:06,858 --> 02:18:07,325 BUPRENORPHINE. 3722 02:18:07,325 --> 02:18:11,163 >> I'LL TAKE A FIRST PASS AT 3723 02:18:11,163 --> 02:18:11,630 THIS. 3724 02:18:11,630 --> 02:18:13,665 I ENCOURAGE CHLOE TO COME OFF 3725 02:18:13,665 --> 02:18:16,535 MIC AND ANSWER. 3726 02:18:16,535 --> 02:18:18,704 FOR RIGHT NOW OPIOIDS ARE 3727 02:18:18,704 --> 02:18:23,175 WRAPPED UP INTO ONE OPIOID USE. 3728 02:18:23,175 --> 02:18:25,377 THAT ONE OPIOID USE CRITERIA SO 3729 02:18:25,377 --> 02:18:26,445 THAT DOES INCLUDE METHADONE 3730 02:18:26,445 --> 02:18:27,145 PRESCRIBED OR NOT. 3731 02:18:27,145 --> 02:18:29,448 SO IN TERMS OF OUR OPIOID 3732 02:18:29,448 --> 02:18:31,516 NUMBERS, THAT INCLUDES A GREATER 3733 02:18:31,516 --> 02:18:33,151 CATCHMENT OF DIFFERENT TYPES OF 3734 02:18:33,151 --> 02:18:33,385 OPIOIDS. 3735 02:18:33,385 --> 02:18:36,788 WHEN THE DATA ARE RELEASED, 3736 02:18:36,788 --> 02:18:37,723 WE'LL HAVE THAT SPECIFIC 3737 02:18:37,723 --> 02:18:40,726 INFORMATION BUT IN TERMS OF OUR 3738 02:18:40,726 --> 02:18:42,360 ENROLLMENT GOALS WE'RE TRYING TO 3739 02:18:42,360 --> 02:18:47,065 LOOK AT OPIOID USE IN GENERAL. 3740 02:18:47,065 --> 02:18:48,567 AND THEN, CHLOE, I DON'T KNOW IF 3741 02:18:48,567 --> 02:18:54,272 YOU HAVE ANYTHING MORE TO ADD. 3742 02:18:54,272 --> 02:18:55,474 >> CAPTURED PRESCRIPTION USE FOR 3743 02:18:55,474 --> 02:18:58,877 PAIN AND OPIOID USE DISORDER AND 3744 02:18:58,877 --> 02:19:00,378 WE'LL HAVE MORE GRANULARITY IN 3745 02:19:00,378 --> 02:19:02,581 TERMS OF WHAT SUBSTANCE OR 3746 02:19:02,581 --> 02:19:05,083 MEDICATIONS USING AND WHY, FOR 3747 02:19:05,083 --> 02:19:06,618 THE ACTUAL DATA, BUT SPECIMENS 3748 02:19:06,618 --> 02:19:08,587 DON'T GIVE US THAT INFORMATION 3749 02:19:08,587 --> 02:19:11,022 BUT WE DO HAVE SEVERAL 3750 02:19:11,022 --> 02:19:12,324 SELF-REPORT SECTIONS WITH THAT 3751 02:19:12,324 --> 02:19:14,926 LEVEL OF DETAIL. 3752 02:19:14,926 --> 02:19:17,696 3753 02:19:17,696 --> 02:19:19,431 >> WE'RE ALREADY TEN MINUTES 3754 02:19:19,431 --> 02:19:21,266 LATE SO WE CAN RETAKE THE 3755 02:19:21,266 --> 02:19:22,868 QUESTIONS LATER ON, ON THE 3756 02:19:22,868 --> 02:19:24,936 DISCUSSION IN THE AFTERNOON. 3757 02:19:24,936 --> 02:19:30,075 AND MEANWHILE THE OTHER THING IS 3758 02:19:30,075 --> 02:19:32,177 OUR AGENDA HAS A BREAK UNTIL 3759 02:19:32,177 --> 02:19:35,213 1:10, WE'RE GOING TO SPEND TO 3760 02:19:35,213 --> 02:19:36,448 1:20 TO GIVE EVERYONE A CHANCE 3761 02:19:36,448 --> 02:19:39,384 TO GET FOOD AND EAT IT AND COME 3762 02:19:39,384 --> 02:19:39,951 BACK. 3763 02:19:39,951 --> 02:19:40,152 1:20. 3764 02:19:40,152 --> 02:19:42,788 >> AND YOU HAVE A MAP ON WHERE 3765 02:19:42,788 --> 02:19:44,523 TO GO TO GET FOOD. 3766 02:19:44,523 --> 02:19:47,392 BUT IF YOU FOLLOW ONE OF THE 3767 02:19:47,392 --> 02:19:48,493 NIAAA COUNCIL MEMBERS THEY WERE 3768 02:19:48,493 --> 02:19:50,495 THERE YET SO THEY KNOW WHERE THE 3769 02:19:50,495 --> 02:19:54,533 FOOD IS. 3770 02:19:54,533 --> 02:19:57,923 YOU CAN BE AMBASSADORS TO LUNCH. 3771 02:20:05,721 --> 02:20:07,289 WE'RE GOING TO START NOW WITH 3772 02:20:07,289 --> 02:20:08,157 THE AFTERNOON SESSION. 3773 02:20:08,157 --> 02:20:12,528 IT'S A PLEASURE FOR ME TO 3774 02:20:12,528 --> 02:20:14,263 INTRODUCE DR. GAYA DOWLING, TO 3775 02:20:14,263 --> 02:20:17,766 GIVE US AN UPDATE ON THE ABCD 3776 02:20:17,766 --> 02:20:21,937 STUDY, ALONG WITH DR. ELIZABETH 3777 02:20:21,937 --> 02:20:23,906 HOFFMAN, DR. KIM LEBLANC. 3778 02:20:23,906 --> 02:20:27,176 GAYA, TAKE IT OVER. 3779 02:20:27,176 --> 02:20:27,710 >> THANK YOU. 3780 02:20:27,710 --> 02:20:29,912 IT'S A PLEASURE TO BE HERE AGAIN 3781 02:20:29,912 --> 02:20:33,849 TO GIVE YOU AN UPDATE ON THE 3782 02:20:33,849 --> 02:20:34,149 STUDY. 3783 02:20:34,149 --> 02:20:35,718 WE'RE GOING TO DO THINGS 3784 02:20:35,718 --> 02:20:36,719 DIFFERENTLY. 3785 02:20:36,719 --> 02:20:38,587 I'M GOING TO GIVE A BRIEF 3786 02:20:38,587 --> 02:20:39,888 OVERVIEW, ALONG WITH MY TEAM, 3787 02:20:39,888 --> 02:20:42,291 AND THEN WE HAVE INVITED SOME 3788 02:20:42,291 --> 02:20:45,227 SPECIAL GUESTS TO TALK MORE 3789 02:20:45,227 --> 02:20:47,229 ABOUT ABCD, DR. MICAH JOHNSON 3790 02:20:47,229 --> 02:20:50,099 WILL TALK ABOUT THE START 3791 02:20:50,099 --> 02:20:52,267 PROGRAM DESIGNED TO BRING IN 3792 02:20:52,267 --> 02:20:52,901 SCHOLARS FROM UNDERREPRESENTED 3793 02:20:52,901 --> 02:20:53,902 BACKGROUNDS TO LEARN ABOUT HOW 3794 02:20:53,902 --> 02:21:01,677 TO USE THE ABCD DATASETS. 3795 02:21:01,677 --> 02:21:02,978 FAITH ADAMS IS A SCHOLAR FROM 3796 02:21:02,978 --> 02:21:05,414 THE FIRST YEAR TO PRESENT THE 3797 02:21:05,414 --> 02:21:05,848 DATA. 3798 02:21:05,848 --> 02:21:07,149 AND NATHANIEL HARNETT, NOT PART 3799 02:21:07,149 --> 02:21:08,717 OF THE CONSORTIUM BUT DOING 3800 02:21:08,717 --> 02:21:13,288 IMPORTANT WORK USING ABCD DATA. 3801 02:21:13,288 --> 02:21:17,359 I WANTED TO START WITH A BRIEF 3802 02:21:17,359 --> 02:21:19,762 OVERVIEW, AND TALK ABOUT 3803 02:21:19,762 --> 02:21:20,396 RETENTION. 3804 02:21:20,396 --> 02:21:22,431 I KNOW MOST OF YOU KNOW A LOT 3805 02:21:22,431 --> 02:21:24,133 ABOUT ABCD, BUT THERE ARE A FEW 3806 02:21:24,133 --> 02:21:25,567 NEW COUNCIL MEMBERS SO I THOUGHT 3807 02:21:25,567 --> 02:21:28,837 I WOULD GIVE A VERY BRIEF 3808 02:21:28,837 --> 02:21:31,240 INTRODUCTION TO THE STUDY. 3809 02:21:31,240 --> 02:21:33,575 SO, ABCD IS A LONGITUDINAL 3810 02:21:33,575 --> 02:21:36,044 STUDY, CLOSE TO 12,000 YOUTH, 3811 02:21:36,044 --> 02:21:38,480 THAT BEGAN WHEN THEY WERE 9 TO 3812 02:21:38,480 --> 02:21:40,816 10 YEARS OLD, CONTINUING FOR A 3813 02:21:40,816 --> 02:21:41,884 DECADE, AT LEAST. 3814 02:21:41,884 --> 02:21:44,853 TO LOOK AT THE VARIOUS FACTORS 3815 02:21:44,853 --> 02:21:48,223 THAT INFLUENCE VARIOUS 3816 02:21:48,223 --> 02:21:48,791 DEVELOPMENTAL TRAJECTORIES. 3817 02:21:48,791 --> 02:21:50,659 WE COLLECT A VAST AMOUNT OF DATA 3818 02:21:50,659 --> 02:21:53,362 SO I'M GOING TO TOUCH QUICKLY ON 3819 02:21:53,362 --> 02:21:54,930 ALL THE DIFFERENT DOMAINS. 3820 02:21:54,930 --> 02:21:58,534 SO, WE HAVE INFORMATION IN THE 3821 02:21:58,534 --> 02:22:00,936 PHYSICAL HEALTH DOMAIN, SO 3822 02:22:00,936 --> 02:22:02,671 INCLUDES ANTHROPOMETRICS, SLEEP, 3823 02:22:02,671 --> 02:22:02,971 ACTIVITIES. 3824 02:22:02,971 --> 02:22:05,307 WE HAVE QUESTIONNAIRES IN THE 3825 02:22:05,307 --> 02:22:07,810 MENTAL HEALTH DOMAIN. 3826 02:22:07,810 --> 02:22:09,912 AND THESE ARE ASKED OF BOTH THE 3827 02:22:09,912 --> 02:22:14,917 YOUTH AS WELL AS CAREGIVER. 3828 02:22:14,917 --> 02:22:18,120 WE ASK ABOUT SUBSTANCE USE, 3829 02:22:18,120 --> 02:22:19,321 CULTURE AND ENVIRONMENT, 3830 02:22:19,321 --> 02:22:21,056 INCLUDING NEIGHBORHOOD SAFETY, 3831 02:22:21,056 --> 02:22:23,492 SCHOOL ENVIRONMENT, FAMILY 3832 02:22:23,492 --> 02:22:25,894 ENVIRONMENT, ALSO INCLUDES 3833 02:22:25,894 --> 02:22:26,495 ACCULTURATION, DISCRIMINATION, 3834 02:22:26,495 --> 02:22:28,263 VARIOUS OTHER MEASURES. 3835 02:22:28,263 --> 02:22:28,964 WE COLLECT BIOSPECIMENS WHICH 3836 02:22:28,964 --> 02:22:32,501 YOU'LL HEAR ABOUT MORE LATER ON. 3837 02:22:32,501 --> 02:22:34,736 ABOUT TWO YEARS INTO THE STUDY 3838 02:22:34,736 --> 02:22:37,906 WE BEGAN TO INTRODUCE FITBIT TO 3839 02:22:37,906 --> 02:22:39,675 GET OBJECTIVE DATA ON ACTIVITY 3840 02:22:39,675 --> 02:22:42,411 AND SLEEP AND HEART RATE. 3841 02:22:42,411 --> 02:22:44,246 AND THEN WE ALSO ADDED ANOTHER 3842 02:22:44,246 --> 02:22:45,981 TECHNOLOGY WHICH IS AN APP FOR 3843 02:22:45,981 --> 02:22:48,317 THE YOUTH CELL PHONES TO BE ABLE 3844 02:22:48,317 --> 02:22:50,052 TO CAPTURE SOME OBJECTIVE DATA 3845 02:22:50,052 --> 02:22:51,587 ON THEIR CELL PHONE USE. 3846 02:22:51,587 --> 02:22:54,656 AND THEN OF COURSE WE HAVE 3847 02:22:54,656 --> 02:22:56,725 NEUROCOGNITIVE TASKS, AND WE DO 3848 02:22:56,725 --> 02:23:00,028 BOTH STRUCTURAL AND FUNCTIONAL 3849 02:23:00,028 --> 02:23:00,896 MRI. 3850 02:23:00,896 --> 02:23:02,531 AND ALL OF THESE -- THE 3851 02:23:02,531 --> 02:23:06,335 PROTOCOL, IT'S A BIG PROTOCOL 3852 02:23:06,335 --> 02:23:10,706 THAT INCLUDES THE MRI EVERY 3853 02:23:10,706 --> 02:23:12,941 OTHER YEAR. 3854 02:23:12,941 --> 02:23:15,310 INTERVENING YEAR HAS DIFFERENT 3855 02:23:15,310 --> 02:23:16,445 COGNITIVE TESTS, AND 3856 02:23:16,445 --> 02:23:17,312 QUESTIONNAIRE DATA BUT NO MRI. 3857 02:23:17,312 --> 02:23:20,949 EVERY SIX MONTHS WE HAVE A TOUCH 3858 02:23:20,949 --> 02:23:22,584 BASE, WAS PHONE, NOW MORE 3859 02:23:22,584 --> 02:23:23,118 ONLINE. 3860 02:23:23,118 --> 02:23:33,629 AND YOU CAN BARELY SEE AT THE 3861 02:23:36,665 --> 02:23:37,933 BOTTOM THERE THE TIMELINE. 3862 02:23:37,933 --> 02:23:40,769 NO, IT DOESN'T SHOW THERE. 3863 02:23:40,769 --> 02:23:41,637 OH WELL. 3864 02:23:41,637 --> 02:23:42,704 IT SHOWS THE TIMELINE SO THE 3865 02:23:42,704 --> 02:23:47,342 IDEA WAS FOR THIS TO GO FOR TEN 3866 02:23:47,342 --> 02:23:48,510 YEARS OF DATA COLLECTION. 3867 02:23:48,510 --> 02:23:50,279 IN ADDITION TO PRIMARY DATA 3868 02:23:50,279 --> 02:23:51,713 COLLECTED FROM PARTICIPANTS, WE 3869 02:23:51,713 --> 02:23:53,549 ALSO HAVE RESIDENTIAL HISTORY 3870 02:23:53,549 --> 02:23:55,050 DERIVED GEO CODES THAT WE'VE 3871 02:23:55,050 --> 02:23:57,286 LINKED TO A LOT OF EXTERNAL 3872 02:23:57,286 --> 02:23:57,553 DATASETS. 3873 02:23:57,553 --> 02:23:58,921 THIS HAS BEEN REALLY IMPORTANT 3874 02:23:58,921 --> 02:24:01,757 BECAUSE IT ALLOWS INVESTIGATORS 3875 02:24:01,757 --> 02:24:03,358 TO CONTEXTUALIZE DATA THEY ARE 3876 02:24:03,358 --> 02:24:04,259 COLLECTING FROM PARTICIPANTS 3877 02:24:04,259 --> 02:24:05,460 BASED ON WHAT'S GOING ON AROUND 3878 02:24:05,460 --> 02:24:08,764 THEM SO IT HAS INFORMATION ABOUT 3879 02:24:08,764 --> 02:24:10,933 AIR POLLUTION, ABOUT PROXIMITY 3880 02:24:10,933 --> 02:24:13,001 TO ROADS, NOISE POLLUTION, ALSO 3881 02:24:13,001 --> 02:24:15,871 HAS INFORMATION ABOUT STATE 3882 02:24:15,871 --> 02:24:18,273 LEVEL POLICIES, SO REALLY HELPS 3883 02:24:18,273 --> 02:24:20,576 EVERYBODY USING THE DATA TO PUT 3884 02:24:20,576 --> 02:24:22,210 IT IN THE CONTEXT OF WHERE THE 3885 02:24:22,210 --> 02:24:24,846 YOUTH ARE ACTUALLY LIVING. 3886 02:24:24,846 --> 02:24:27,482 SO THAT'S VERY, YOU KNOW, BREEZY 3887 02:24:27,482 --> 02:24:28,784 OVERVIEW, I'M HAPPY TO TALK TO 3888 02:24:28,784 --> 02:24:31,086 ANYBODY WHO WANTS MORE DETAILS 3889 02:24:31,086 --> 02:24:31,286 LATER. 3890 02:24:31,286 --> 02:24:34,256 ONE OF THE THINGS WE HAVE BEEN 3891 02:24:34,256 --> 02:24:36,224 FOCUSED A LOT IS DIVERSITY IN 3892 02:24:36,224 --> 02:24:37,593 THE COHORT, AND YOU MAY KNOW 3893 02:24:37,593 --> 02:24:39,628 THAT THE "ALL OF US" RESEARCH 3894 02:24:39,628 --> 02:24:44,866 PROGRAM HAS USED AN EXPANDED AND 3895 02:24:44,866 --> 02:24:49,237 MORE ENCOMPASSING DEFINITION OF 3896 02:24:49,237 --> 02:24:49,571 DIVERSITY. 3897 02:24:49,571 --> 02:24:51,373 WE WANTED TO INCLUDE ALL THESE 3898 02:24:51,373 --> 02:24:53,875 CATEGORIES, SO "ALL OF US" HAS 3899 02:24:53,875 --> 02:24:57,045 RACE AND ETHNICITY, ACCESS TO 3900 02:24:57,045 --> 02:24:59,448 CARE, HOUSEHOLD INCOME, 3901 02:24:59,448 --> 02:25:00,882 EDUCATIONAL ATTAINMENT, GENDER 3902 02:25:00,882 --> 02:25:02,184 IDENTITY, GEOGRAPHY, SEX 3903 02:25:02,184 --> 02:25:03,819 ASSIGNED AT BIRTH, SEXUAL 3904 02:25:03,819 --> 02:25:05,354 ORIENTATION, AND THEY ALSO 3905 02:25:05,354 --> 02:25:06,488 INCLUDE AGE WHICH ISN'T REALLY 3906 02:25:06,488 --> 02:25:07,756 RELEVANT TO US SINCE THEY ARE 3907 02:25:07,756 --> 02:25:09,725 ALL THE SAME AGE. 3908 02:25:09,725 --> 02:25:11,193 AND DISABILITY WHICH WE DON'T AT 3909 02:25:11,193 --> 02:25:13,662 THE MOMENT HAVE A GOOD QUESTION 3910 02:25:13,662 --> 02:25:16,732 THAT CAN BE USED TO ADDRESS 3911 02:25:16,732 --> 02:25:17,366 THAT. 3912 02:25:17,366 --> 02:25:19,468 SO HERE YOU CAN SEE FOR EACH 3913 02:25:19,468 --> 02:25:20,235 INDIVIDUAL CATEGORY THE 3914 02:25:20,235 --> 02:25:21,770 PROPORTION OF THE COHORT THAT 3915 02:25:21,770 --> 02:25:22,971 FALLS INTO IT. 3916 02:25:22,971 --> 02:25:24,840 BUT I THINK WHAT'S MOST 3917 02:25:24,840 --> 02:25:26,608 INTERESTING WHEN WE LOOK AT THE 3918 02:25:26,608 --> 02:25:30,212 COHORT AS A WHOLE, SO 70% OF THE 3919 02:25:30,212 --> 02:25:32,080 SAMPLE IS REPRESENTED IN AT 3920 02:25:32,080 --> 02:25:34,783 LEAST ONE CATEGORY OF PEOPLE WHO 3921 02:25:34,783 --> 02:25:35,317 ARE UNDERREPRESENTED IN 3922 02:25:35,317 --> 02:25:36,184 BIOMEDICAL RESEARCH. 3923 02:25:36,184 --> 02:25:37,419 WHAT I THINK IS INTERESTING IS 3924 02:25:37,419 --> 02:25:40,922 THAT WE'VE GOT MORE THAN 3,000 3925 02:25:40,922 --> 02:25:43,558 THAT ARE REPRESENTED IN TWO 3926 02:25:43,558 --> 02:25:44,559 CATEGORIES, ALMOST A THOUSAND 3927 02:25:44,559 --> 02:25:45,627 REPRESENTED IN THREE CATEGORIES. 3928 02:25:45,627 --> 02:25:46,728 THIS IS IMPORTANT BECAUSE WE'RE 3929 02:25:46,728 --> 02:25:51,667 SEEING A LOT MORE RESEARCH BEING 3930 02:25:51,667 --> 02:25:52,467 DONE LOOKING AT 3931 02:25:52,467 --> 02:25:52,868 INTERSECTIONALITY. 3932 02:25:52,868 --> 02:25:56,238 IN TERMS OF WHERE WE ARE TODAY 3933 02:25:56,238 --> 02:25:59,408 IN ABCD, SO WE ARE -- WE'VE JUST 3934 02:25:59,408 --> 02:26:01,710 BEGUN OUR 7-YEAR FOLLOW-UP 3935 02:26:01,710 --> 02:26:03,145 PROTOCOL, THAT BEGAN LAST FALL. 3936 02:26:03,145 --> 02:26:04,579 YOU CAN SEE HERE KIND OF THE 3937 02:26:04,579 --> 02:26:07,315 PROGRESS FROM YEAR TO YEAR. 3938 02:26:07,315 --> 02:26:09,584 SO THE BLUE INDICATES THE 3939 02:26:09,584 --> 02:26:11,253 COMPLETED VISITS, THE BLACK ARE 3940 02:26:11,253 --> 02:26:13,655 THOSE THAT ARE WITHDRAWN. 3941 02:26:13,655 --> 02:26:16,058 THE WITHDRAWAL RATE IS STILL 3942 02:26:16,058 --> 02:26:16,591 VERY SMALL. 3943 02:26:16,591 --> 02:26:18,493 THE ORANGE ARE THE PEOPLE WHO 3944 02:26:18,493 --> 02:26:19,795 HAVE MISSED VISITS. 3945 02:26:19,795 --> 02:26:21,763 AND THE GRAY ARE PENDING VISITS. 3946 02:26:21,763 --> 02:26:25,033 THEY ARE NOT DUE TO COME IN YET 3947 02:26:25,033 --> 02:26:26,334 FOR THEIR VISITS. 3948 02:26:26,334 --> 02:26:28,737 I HIGHLIGHT THERE THE COVID 3949 02:26:28,737 --> 02:26:30,272 PANDEMIC BECAUSE IT WAS QUITE 3950 02:26:30,272 --> 02:26:32,274 DISRUPTIVE TO THE PROCESS OF A 3951 02:26:32,274 --> 02:26:32,808 LONGITUDINAL STUDY. 3952 02:26:32,808 --> 02:26:34,676 THANKFULLY WE WERE ABLE TO 3953 02:26:34,676 --> 02:26:35,410 CONTINUE TO COLLECT DATA. 3954 02:26:35,410 --> 02:26:38,613 YOU WILL SEE THE MISSINGNESS 3955 02:26:38,613 --> 02:26:40,749 RATES ARE HIGHER DURING THAT 3956 02:26:40,749 --> 02:26:40,982 PERIOD. 3957 02:26:40,982 --> 02:26:42,617 THE PANDEMIC HIT WHEN WE WERE 3958 02:26:42,617 --> 02:26:44,386 ABOUT THREE-QUARTERS OF THE WAY 3959 02:26:44,386 --> 02:26:45,921 THROUGH WITH TWO-YEAR FOLLOW-UP. 3960 02:26:45,921 --> 02:26:48,023 VERY MUCH IMPACTED OUR THREE AND 3961 02:26:48,023 --> 02:26:50,425 FOUR-YEAR FOLLOW-UP TIME POINTS. 3962 02:26:50,425 --> 02:26:52,060 AND THEN AS THINGS STARTED TO 3963 02:26:52,060 --> 02:26:55,664 GET BACK TO NORMAL WE RECOGNIZED 3964 02:26:55,664 --> 02:26:57,566 THAT OUR WINDOW OF BRINGING 3965 02:26:57,566 --> 02:26:59,334 PEOPLE IN HAD SHIFTED BECAUSE 3966 02:26:59,334 --> 02:27:01,303 THINGS HAD BEEN DELAYED. 3967 02:27:01,303 --> 02:27:05,073 AND SO WITH THE FIVE-YEAR 3968 02:27:05,073 --> 02:27:10,579 PROTOCOL WE HAD SITES TRY TO 3969 02:27:10,579 --> 02:27:15,617 REANCHOR PARTICIPANTS TO 3970 02:27:15,617 --> 02:27:18,120 ORIGINAL DATE REQUIRING SOME TO 3971 02:27:18,120 --> 02:27:19,888 SKIP THE FIVE YEAR AND JUMP TO 3972 02:27:19,888 --> 02:27:20,455 THE SIX-YEAR. 3973 02:27:20,455 --> 02:27:22,858 THAT'S THE TAN BAR. 3974 02:27:22,858 --> 02:27:24,392 SIX-YEAR FOLLOW-UP, WE'RE BACK 3975 02:27:24,392 --> 02:27:26,695 ON TRACK, IS GOING MUCH BETTER 3976 02:27:26,695 --> 02:27:28,063 AND MISSINGNESS IS MUCH SMALLER, 3977 02:27:28,063 --> 02:27:31,166 SIMILAR TO WHAT IT WAS IN THE 3978 02:27:31,166 --> 02:27:31,933 BEGINNING. 3979 02:27:31,933 --> 02:27:35,303 BUT WHAT WE'RE PARTICULARLY 3980 02:27:35,303 --> 02:27:37,873 AWARE OF IS DESPITE THE FACT OUR 3981 02:27:37,873 --> 02:27:39,608 WITHDRAWAL RATES ARE VERY LOW WE 3982 02:27:39,608 --> 02:27:42,544 DO HAVE PARTICIPANTS THAT HAVE 3983 02:27:42,544 --> 02:27:45,280 MISSED SEVERAL VISITS IN A ROW, 3984 02:27:45,280 --> 02:27:46,815 THAT ARE AT RISK OF WITHDRAWAL. 3985 02:27:46,815 --> 02:27:50,552 SO WE HAVE ON OUR DASHBOARD THE 3986 02:27:50,552 --> 02:27:52,187 ABILITY TO LOOK AT VISIT 3987 02:27:52,187 --> 02:27:53,054 PATTERNS, HOW MANY PARTICIPANTS 3988 02:27:53,054 --> 02:27:55,023 COME IN FOR ALL OF THEIR VISITS, 3989 02:27:55,023 --> 02:27:58,093 HOW MANY MISSED A VISIT AND COME 3990 02:27:58,093 --> 02:28:01,029 BACK, SO THE FIRST THREE ROWS, 3991 02:28:01,029 --> 02:28:02,364 ABOUT 7800 PARTICIPANTS HAVE 3992 02:28:02,364 --> 02:28:03,365 NEVER MISSED A VISIT. 3993 02:28:03,365 --> 02:28:06,268 THEY HAVE ATTENDED ALL OF THEIR 3994 02:28:06,268 --> 02:28:06,501 VISITS. 3995 02:28:06,501 --> 02:28:08,270 AND THEN YOU'LL SEE SOME 3996 02:28:08,270 --> 02:28:09,771 PARTICIPANTS THAT HAVE MISSED A 3997 02:28:09,771 --> 02:28:11,406 VISIT, THAT'S THE RED DOT, BUT 3998 02:28:11,406 --> 02:28:13,708 THEN COME BACK FOR SUBSEQUENT 3999 02:28:13,708 --> 02:28:13,975 VISITS. 4000 02:28:13,975 --> 02:28:15,243 SO THAT'S REALLY IMPORTANT, THAT 4001 02:28:15,243 --> 02:28:16,912 OUR SITES ARE DOING A GOOD JOB 4002 02:28:16,912 --> 02:28:18,246 BRINGING PEOPLE BACK EVEN IF 4003 02:28:18,246 --> 02:28:21,850 THEY HAVE MISSED A VISIT. 4004 02:28:21,850 --> 02:28:22,818 ONES WE'RE MOST CONCERNED ABOUT 4005 02:28:22,818 --> 02:28:24,920 ARE THESE WHERE THEY HAVE MISSED 4006 02:28:24,920 --> 02:28:26,555 VISITS, THEY HAVEN'T COME IN 4007 02:28:26,555 --> 02:28:27,989 SINCE THE TWO-YEAR FOLLOW-UP. 4008 02:28:27,989 --> 02:28:31,259 THIS IS THE GROUP OF 4009 02:28:31,259 --> 02:28:31,893 PARTICIPANTS THAT WE'RE MOST 4010 02:28:31,893 --> 02:28:33,428 FOCUSED ON. 4011 02:28:33,428 --> 02:28:37,632 AND IF WE LOOK AT THE DATA ON 4012 02:28:37,632 --> 02:28:41,536 THE EXTENDED ABSENCES, THIS IS 4013 02:28:41,536 --> 02:28:45,740 ALL DONE BY DIANA ALKIRE ON THE 4014 02:28:45,740 --> 02:28:48,310 TEAM, WE HAD 750 LAST MARCH THAT 4015 02:28:48,310 --> 02:28:49,611 WERE IN THIS EXTENDED ABSENCE 4016 02:28:49,611 --> 02:28:49,878 CATEGORY. 4017 02:28:49,878 --> 02:28:53,582 AND AS OF THIS APRIL, THAT'S 4018 02:28:53,582 --> 02:28:54,749 GONE DOWN TO 550. 4019 02:28:54,749 --> 02:28:56,852 SO, ONE OF THE THINGS WE DID AT 4020 02:28:56,852 --> 02:28:58,620 THIS TIME IS WE LOOKED AT THE 4021 02:28:58,620 --> 02:29:01,022 SITES THAT WERE NOT HAVING THIS 4022 02:29:01,022 --> 02:29:01,990 EXTENDED ABSENCE PROBLEM BECAUSE 4023 02:29:01,990 --> 02:29:04,192 THERE'S SOME SITES JUST DOING AN 4024 02:29:04,192 --> 02:29:05,861 AMAZING JOB BRINGING EVERYBODY 4025 02:29:05,861 --> 02:29:06,061 IN. 4026 02:29:06,061 --> 02:29:09,331 AND WE TALKED TO THEM ABOUT WHAT 4027 02:29:09,331 --> 02:29:10,298 THEIR TRICKS WERE. 4028 02:29:10,298 --> 02:29:12,067 AND WE HEARD A LOT OF THINGS, 4029 02:29:12,067 --> 02:29:13,602 ESSENTIALLY WHAT WE CAME UP IS 4030 02:29:13,602 --> 02:29:17,772 THERE IS NO SECRET SAUCE, A LOT 4031 02:29:17,772 --> 02:29:20,375 OF THINGS SITES DO TO MAKE 4032 02:29:20,375 --> 02:29:24,746 EASIER FOR FAMILIES TO 4033 02:29:24,746 --> 02:29:25,614 PARTICIPATE, AND MARIA DUBINSKY 4034 02:29:25,614 --> 02:29:27,949 AT THE UNIVERSITY OF MICHIGAN 4035 02:29:27,949 --> 02:29:30,685 PUT TOGETHER THIS GRAPHIC TO 4036 02:29:30,685 --> 02:29:32,220 HELP THE SITE COORDINATORS, 4037 02:29:32,220 --> 02:29:33,755 SCHEDULERS, TO FIGURE OUT WHAT 4038 02:29:33,755 --> 02:29:36,024 THEY CAN DO TO ENHANCE THE 4039 02:29:36,024 --> 02:29:37,125 EXPERIENCE FOR THEIR 4040 02:29:37,125 --> 02:29:38,994 PARTICIPANTS, SO THIS INCLUDES 4041 02:29:38,994 --> 02:29:41,396 THINGS LIKE TRANSPORTATION AND 4042 02:29:41,396 --> 02:29:43,398 CHILD CARE, SOME SITES GIVING 4043 02:29:43,398 --> 02:29:44,666 BONUS PAYMENTS. 4044 02:29:44,666 --> 02:29:46,868 A NUMBER OF STRATEGIES SO WE CAN 4045 02:29:46,868 --> 02:29:48,570 TRY TO BRING BACK IN BOTH THE 4046 02:29:48,570 --> 02:29:50,038 PEOPLE THAT WE MAY HAVE LOST 4047 02:29:50,038 --> 02:29:52,107 DURING THE PANDEMIC AS WELL AS 4048 02:29:52,107 --> 02:29:59,848 SOME OF THOSE EXTENDED ABSENCE 4049 02:29:59,848 --> 02:30:00,348 FOLKS. 4050 02:30:00,348 --> 02:30:02,951 I'D LIKE TO GIVE A BRIEF UPDATE 4051 02:30:02,951 --> 02:30:05,587 ON OUR JEDI ACTIVITIES. 4052 02:30:05,587 --> 02:30:08,323 LAST YEAR YOU HEARD FROM 4053 02:30:08,323 --> 02:30:11,059 LIEUTENANT COMMANDER TRACY 4054 02:30:11,059 --> 02:30:12,027 MURRAY, ABOUT EFFORTS TO ENHANCE 4055 02:30:12,027 --> 02:30:16,097 DIVERSITY, EQUITY, INCLUSION, 4056 02:30:16,097 --> 02:30:20,902 AND ACCESSIBILITY IN ABCD, USING 4057 02:30:20,902 --> 02:30:21,770 RESET, RESTRUCTURE, REENGAGE. 4058 02:30:21,770 --> 02:30:23,204 WE CONDUCTED A CLIMATE SURVEY, 4059 02:30:23,204 --> 02:30:27,242 I'LL TALK MORE ABOUT THAT ON THE 4060 02:30:27,242 --> 02:30:28,543 NEXT SLIDE. 4061 02:30:28,543 --> 02:30:30,178 TO REALLY UNDERSTAND HOW PEOPLE 4062 02:30:30,178 --> 02:30:32,580 IN THE CONSORTIUM WERE FEELING 4063 02:30:32,580 --> 02:30:33,882 AT VARIOUS LEVELS. 4064 02:30:33,882 --> 02:30:34,849 IN TERMS OF RESTRUCTURING, ONE 4065 02:30:34,849 --> 02:30:38,286 OF THE THINGS WE WANTED TO DO IS 4066 02:30:38,286 --> 02:30:40,488 ALSO EXPAND EFFORTS BEYOND 4067 02:30:40,488 --> 02:30:41,389 RACIAL DISCRIMINATION TO OTHER 4068 02:30:41,389 --> 02:30:44,626 MARGINALIZED GROUPS, AS PART OF 4069 02:30:44,626 --> 02:30:47,896 THAT WE'VE ALSO EXPANDED THE 4070 02:30:47,896 --> 02:30:50,765 MEMBERSHIP OF OUR JEDI ADVISORY 4071 02:30:50,765 --> 02:30:51,166 COUNCIL. 4072 02:30:51,166 --> 02:30:54,069 WE STARTED HAVING DIFFERENT 4073 02:30:54,069 --> 02:30:57,238 EVENTS THROUGHOUT THE YEAR, TO 4074 02:30:57,238 --> 02:30:58,773 FOCUS ON JEDI FACTORS. 4075 02:30:58,773 --> 02:31:02,377 SO FOR EXAMPLE WE HAVE NOW THESE 4076 02:31:02,377 --> 02:31:03,244 QUARTERLY JEDI ALL-HANDS 4077 02:31:03,244 --> 02:31:04,879 MEETINGS, AND THEY FOCUS ON 4078 02:31:04,879 --> 02:31:05,280 DIFFERENT TOPICS. 4079 02:31:05,280 --> 02:31:07,515 ONE WAS LOOKING AT THE FEDERAL 4080 02:31:07,515 --> 02:31:09,484 RACIAL AND ETHNIC CATEGORIES, WE 4081 02:31:09,484 --> 02:31:10,485 BRING IN OUTSIDE SPEAKERS TO 4082 02:31:10,485 --> 02:31:11,353 TALK ABOUT THAT. 4083 02:31:11,353 --> 02:31:14,189 ONE WAS ON MEDICAL MISTRUST. 4084 02:31:14,189 --> 02:31:16,825 AND MOST RECENT WAS AUTISM 4085 02:31:16,825 --> 02:31:17,926 AWARENESS. 4086 02:31:17,926 --> 02:31:19,894 AND THEN TRACY ALSO DOES THESE 4087 02:31:19,894 --> 02:31:22,530 TRAININGS FOR ALL OF OUR 4088 02:31:22,530 --> 02:31:24,699 INVESTIGATORS AS WELL AS RAs 4089 02:31:24,699 --> 02:31:26,368 ON VARIOUS TOPICS, AND WE'VE 4090 02:31:26,368 --> 02:31:27,335 DONE -- WHICH WE'RE GOING TO BE 4091 02:31:27,335 --> 02:31:28,870 DOING MORE OF IN THE COMING 4092 02:31:28,870 --> 02:31:29,070 YEAR. 4093 02:31:29,070 --> 02:31:31,506 AND WE'VE DONE A LITTLE BIT MORE 4094 02:31:31,506 --> 02:31:33,575 INTEGRATION AMONG SOME OF OUR 4095 02:31:33,575 --> 02:31:35,110 JEDI FOLKS INTO ALL OF THE 4096 02:31:35,110 --> 02:31:37,946 DIFFERENT WORK GROUPS THROUGHOUT 4097 02:31:37,946 --> 02:31:39,147 THE CONSORTIUM. 4098 02:31:39,147 --> 02:31:41,149 SO, FOR THE CLIMATE SURVEY, WE 4099 02:31:41,149 --> 02:31:42,984 HAVE THE JEDI ADVISORY COUNCIL 4100 02:31:42,984 --> 02:31:44,285 IN OUR COORDINATING CENTER WORK 4101 02:31:44,285 --> 02:31:46,187 TOGETHER TO BRING IN EXTERNAL 4102 02:31:46,187 --> 02:31:48,790 CONSULTANT TO DO A SURVEY OF THE 4103 02:31:48,790 --> 02:31:49,190 ENTIRE CONSORTIUM. 4104 02:31:49,190 --> 02:31:52,761 SO THIS INVOLVED ALL THE 4105 02:31:52,761 --> 02:31:55,830 INVESTIGATORS, R.A.s, SITE 4106 02:31:55,830 --> 02:31:56,965 COORDINATORS AT ALL LEVELS TO 4107 02:31:56,965 --> 02:31:58,533 LOOK AT CLIMATE AT THE 4108 02:31:58,533 --> 02:31:59,434 INDIVIDUAL SITES AND CLIMATE IN 4109 02:31:59,434 --> 02:32:03,238 THE CONSORTIUM AS A WHOLE, 4110 02:32:03,238 --> 02:32:04,472 SIMILAR FOR HBCD, WE HAVE MANY 4111 02:32:04,472 --> 02:32:06,107 WORK GROUPS AND WE'VE GOT PEOPLE 4112 02:32:06,107 --> 02:32:07,409 PARTICIPATING IN ALL THOSE WORK 4113 02:32:07,409 --> 02:32:08,643 GROUPS SO WE WANTED TO LOOK BOTH 4114 02:32:08,643 --> 02:32:09,844 AT HOW PEOPLE ARE FEELING AT 4115 02:32:09,844 --> 02:32:16,484 THEIR SITES AS WELL AS IN 4116 02:32:16,484 --> 02:32:19,120 CONSORTIUM-WIDE ACTIVITIES. 4117 02:32:19,120 --> 02:32:20,655 SHOWN HERE 92% AGREED ABCD HAS A 4118 02:32:20,655 --> 02:32:22,424 STRONG COMPLIMENT TO JEDI 4119 02:32:22,424 --> 02:32:25,160 VALUES, WHICH IS WONDERFUL. 4120 02:32:25,160 --> 02:32:26,795 IT ALSO RAISED SOME CONCERNS IN 4121 02:32:26,795 --> 02:32:29,297 DIFFERENT LAYERS, SOME AT THE 4122 02:32:29,297 --> 02:32:31,266 SITES, SOME AT CONSORTIUM LEVEL, 4123 02:32:31,266 --> 02:32:33,234 AREAS WE MIGHT NEED IMPROVEMENT, 4124 02:32:33,234 --> 02:32:36,237 TAKING RECOMMENDATIONS AND 4125 02:32:36,237 --> 02:32:38,306 MAKING CHANGES. 4126 02:32:38,306 --> 02:32:41,276 I NOW WANT TO TALK ABOUT HOW 4127 02:32:41,276 --> 02:32:42,877 PEOPLE ARE LEVERAGING ABCD. 4128 02:32:42,877 --> 02:32:45,747 SO I BELIEVE I MENTIONED LAST 4129 02:32:45,747 --> 02:32:48,917 YEAR OUR PARTICIPATION IN THE 4130 02:32:48,917 --> 02:32:51,252 NIH RECOVER INITIATIVE, THE 4131 02:32:51,252 --> 02:32:52,954 RESEARCH IN COVID, LONG COVID 4132 02:32:52,954 --> 02:32:53,655 INITIATIVE AT NIH. 4133 02:32:53,655 --> 02:32:55,390 WE THOUGHT IT WAS PARTICULARLY 4134 02:32:55,390 --> 02:32:56,791 IMPORTANT FOR ABCD TO BE PART OF 4135 02:32:56,791 --> 02:32:59,761 THIS BECAUSE WE WERE ONE OF THE 4136 02:32:59,761 --> 02:33:03,131 FEW COHORTS THAT IT BRAIN 4137 02:33:03,131 --> 02:33:03,698 IMAGING, COGNITIVE TESTING, 4138 02:33:03,698 --> 02:33:04,466 MENTAL HEALTH MEASURES PRIOR TO 4139 02:33:04,466 --> 02:33:05,667 THE PANDEMIC, INFORMATION DURING 4140 02:33:05,667 --> 02:33:07,402 THE PANDEMIC ABOUT THEIR 4141 02:33:07,402 --> 02:33:08,503 EXPERIENCES, AND WE'RE 4142 02:33:08,503 --> 02:33:13,541 CONTINUING TO FOLLOW THEM FOR AT 4143 02:33:13,541 --> 02:33:14,542 LEAST SOME YEARS AFTER ACUTE 4144 02:33:14,542 --> 02:33:16,177 PHASE OF PANDEMIC. 4145 02:33:16,177 --> 02:33:21,116 WHAT WE MISSED WAS WE DIDN'T 4146 02:33:21,116 --> 02:33:22,851 HAVE ANTIBODY TESTING, RECOVER 4147 02:33:22,851 --> 02:33:25,453 HAS GIVEN US ANTIBODY TESTING. 4148 02:33:25,453 --> 02:33:26,788 ANOTHER SURVEY TALKED ABOUT LONG 4149 02:33:26,788 --> 02:33:27,555 COVID SYMPTOMS. 4150 02:33:27,555 --> 02:33:30,191 FOR THOSE WHO SHOW EVIDENCE OF 4151 02:33:30,191 --> 02:33:32,494 LONG COVID THERE'S ABILITY TO 4152 02:33:32,494 --> 02:33:39,033 PARTICIPATE IN THE TIER 2 OF 4153 02:33:39,033 --> 02:33:40,935 RECOVER INITIATIVE, MORE 4154 02:33:40,935 --> 02:33:41,870 IN-DEPTH ASSESSMENTS. 4155 02:33:41,870 --> 02:33:43,204 WE MADE AN OFFER TO PARTICIPANTS 4156 02:33:43,204 --> 02:33:45,940 WHO WANTED TO PARTICIPATE TO 4157 02:33:45,940 --> 02:33:48,276 PARTICIPATE IN RECOVER. 4158 02:33:48,276 --> 02:33:49,444 6400 ABCD PARTICIPANTS HAVE 4159 02:33:49,444 --> 02:33:50,845 JOINED THE RECOVER INITIATIVE SO 4160 02:33:50,845 --> 02:33:51,746 THEY'VE GOTTEN ANTIBODY TESTING 4161 02:33:51,746 --> 02:33:54,916 AND ARE DOING THE SURVEYS. 4162 02:33:54,916 --> 02:33:57,185 AND THIS IS REALLY AMAZING. 4163 02:33:57,185 --> 02:33:58,520 IN FACT, THE RECOVER PEDIATRIC 4164 02:33:58,520 --> 02:34:01,055 COHORT, 45% OF THEM ARE ABCD 4165 02:34:01,055 --> 02:34:01,389 PARTICIPANTS. 4166 02:34:01,389 --> 02:34:04,325 SO WE'VE DONE A LOT TO ALSO 4167 02:34:04,325 --> 02:34:06,161 ENHANCE THEIR COHORT AS WELL. 4168 02:34:06,161 --> 02:34:09,130 THIS DATA WILL BE RELEASED NOT 4169 02:34:09,130 --> 02:34:12,433 WITH THE UPCOMING DATA RELEASE 4170 02:34:12,433 --> 02:34:14,035 BUT SUBSEQUENT DATA RELEASE. 4171 02:34:14,035 --> 02:34:16,371 WE WERE ALSO APPROACHED BY 4172 02:34:16,371 --> 02:34:18,206 NIDA'S HIV RESEARCH PROGRAM TO 4173 02:34:18,206 --> 02:34:27,415 LOOK AT HOW ABCD MAY BE USED TO 4174 02:34:27,415 --> 02:34:31,252 STUDY HIV. 4175 02:34:31,252 --> 02:34:32,654 AND SO RELA GONZALEZ FROM 4176 02:34:32,654 --> 02:34:33,988 FLORIDA INTERNATIONAL UNIVERSITY 4177 02:34:33,988 --> 02:34:36,057 ORGANIZED A MEETING BRINGING 4178 02:34:36,057 --> 02:34:37,058 TOGETHER THOSE THAT DOMAINS THAT 4179 02:34:37,058 --> 02:34:39,360 MAY BE RELEVANT TO HIV, OUTSIDE 4180 02:34:39,360 --> 02:34:41,229 INVESTIGATORS TO TALK ABOUT WHAT 4181 02:34:41,229 --> 02:34:42,730 WE MIGHT BE MISSING, AND REALLY 4182 02:34:42,730 --> 02:34:45,800 IMPORTANTLY WE HAD A PANEL OF 4183 02:34:45,800 --> 02:34:47,669 YOUNG PEOPLE WHO WERE -- YOUNG 4184 02:34:47,669 --> 02:34:49,337 ADULTS WHO CONTRACTED HIV WHEN 4185 02:34:49,337 --> 02:34:49,704 TEENAGERS. 4186 02:34:49,704 --> 02:34:51,739 SO THEY COULD GIVE US THEIR 4187 02:34:51,739 --> 02:34:53,608 PERSPECTIVE AND WHAT THEY HEARD, 4188 02:34:53,608 --> 02:34:56,110 WHAT THEY WISHED THEY HAD KNOWN, 4189 02:34:56,110 --> 02:34:58,079 IT WAS A RICH DISCUSSION. 4190 02:34:58,079 --> 02:35:00,915 SO COMING OUT OF THAT WE HAVE 4191 02:35:00,915 --> 02:35:02,217 KIND OF AN ASSESSMENT OF WHAT WE 4192 02:35:02,217 --> 02:35:02,984 ALREADY HAVE. 4193 02:35:02,984 --> 02:35:05,620 WE HAVE A LOT OF INFORMATION ON 4194 02:35:05,620 --> 02:35:09,991 MENTAL HEALTH AND GENDER AND 4195 02:35:09,991 --> 02:35:10,792 SEXUAL ORIENTATION, 4196 02:35:10,792 --> 02:35:11,960 DISCRIMINATION, STRUCTURAL 4197 02:35:11,960 --> 02:35:13,161 POLICY, STATE LEVEL POLICIES. 4198 02:35:13,161 --> 02:35:15,129 WE HAVE SOME AREAS THAT WE ARE 4199 02:35:15,129 --> 02:35:16,331 COLLECTING SOME INFORMATION ON 4200 02:35:16,331 --> 02:35:19,534 BUT IT WOULD BE -- MAYBE USEFUL 4201 02:35:19,534 --> 02:35:22,804 TO BROADEN THAT, SO SOCIAL 4202 02:35:22,804 --> 02:35:23,571 SUPPORT, FOR EXAMPLE, 4203 02:35:23,571 --> 02:35:26,007 RELATIONSHIP OF DRUG AND ALCOHOL 4204 02:35:26,007 --> 02:35:27,208 USE, AND SEXUAL ENCOUNTERS. 4205 02:35:27,208 --> 02:35:28,943 AND THEN THERE'S SOME AREAS WE 4206 02:35:28,943 --> 02:35:30,278 DON'T HAVE ANY COVERAGE IN. 4207 02:35:30,278 --> 02:35:32,580 A LOT OF THIS DISCUSSION WAS 4208 02:35:32,580 --> 02:35:34,983 FOCUSED ON IF ABCD IS TO 4209 02:35:34,983 --> 02:35:36,517 CONTINUE WHEN THE KIDS BECOME 4210 02:35:36,517 --> 02:35:37,919 ADULTS, THESE ARE SOME AREAS WE 4211 02:35:37,919 --> 02:35:41,556 MAY WANT TO FOCUS ON IN THAT 4212 02:35:41,556 --> 02:35:42,357 NEXT PHASE. 4213 02:35:42,357 --> 02:35:44,192 SO NOW I'M REALLY EXCITED TO 4214 02:35:44,192 --> 02:35:48,563 TURN IT OVER TO ELIZABETH 4215 02:35:48,563 --> 02:35:50,832 HOFFMAN TO TALK ABOUT RESOURCE 4216 02:35:50,832 --> 02:35:52,500 SHARING, BEGIN TO TALK ABOUT 4217 02:35:52,500 --> 02:35:53,468 RESOURCE SHARING, AND WE'LL TURN 4218 02:35:53,468 --> 02:35:55,236 IT OVER TO KIM TO FINISH THAT 4219 02:35:55,236 --> 02:35:55,570 DISCUSSION. 4220 02:35:55,570 --> 02:35:56,871 ELIZABETH, ARE YOU THERE? 4221 02:35:56,871 --> 02:35:58,539 >> I'M HERE. 4222 02:35:58,539 --> 02:35:59,774 HOPING YOU CAN HEAR MY CLEARLY. 4223 02:35:59,774 --> 02:36:02,243 SORRY I'M NOT THERE IN PERSON. 4224 02:36:02,243 --> 02:36:03,011 NEXT SLIDE. 4225 02:36:03,011 --> 02:36:03,678 GREAT, THANKS. 4226 02:36:03,678 --> 02:36:05,747 I THOUGHT WHERE I WOULD START IS 4227 02:36:05,747 --> 02:36:09,350 JUST WITH A QUICK SNAPSHOT OF 4228 02:36:09,350 --> 02:36:11,653 WHERE WE ARE WITH DATA 4229 02:36:11,653 --> 02:36:12,987 AVAILABILITY. 4230 02:36:12,987 --> 02:36:15,023 DATA HAS BEEN RELEASED THROUGH 4231 02:36:15,023 --> 02:36:18,126 THE DATA ARCHIVE THAT INCLUDES 4232 02:36:18,126 --> 02:36:20,161 CURRENT DATA RELEASE, ABCD 5.1. 4233 02:36:20,161 --> 02:36:23,998 THIS INCLUDES DATA ON THE FULL 4234 02:36:23,998 --> 02:36:24,866 PARTICIPANT COHORT, THROUGH 4235 02:36:24,866 --> 02:36:25,533 THREE-YEAR FOLLOW-UP TIME POINT 4236 02:36:25,533 --> 02:36:27,235 AS WELL AS A PORTION OR 4237 02:36:27,235 --> 02:36:29,237 SIGNIFICANT PORTION OF THE 4238 02:36:29,237 --> 02:36:31,773 FOUR-YEAR FOLLOW-UP DATA AS 4239 02:36:31,773 --> 02:36:31,973 WELL. 4240 02:36:31,973 --> 02:36:37,045 AND THESE ARE ALL AVAILABLE, 4241 02:36:37,045 --> 02:36:40,682 TABULATED DATA AS A DOWNLOADABLE 4242 02:36:40,682 --> 02:36:45,820 ZIP FILE, RAW IMAGING FILES ARE 4243 02:36:45,820 --> 02:36:47,655 AVAILABLE VIA THE DOWNLOAD TOOL. 4244 02:36:47,655 --> 02:36:49,090 WE MADE AVAILABLE A COLLECTION 4245 02:36:49,090 --> 02:36:51,059 OF DATA RESOURCES, WHICH ARE NEW 4246 02:36:51,059 --> 02:36:52,260 WITH THIS LATEST RELEASE. 4247 02:36:52,260 --> 02:36:54,562 AND THESE ARE LISTED HERE ON THE 4248 02:36:54,562 --> 02:36:55,430 RIGHT. 4249 02:36:55,430 --> 02:36:58,933 WE HAVE AN ABCD WIKI, AN AMAZING 4250 02:36:58,933 --> 02:37:02,637 RESOURCE THAT GIVES UPDATED AND 4251 02:37:02,637 --> 02:37:04,439 TIMELY INFORMATION ABOUT THE 4252 02:37:04,439 --> 02:37:06,374 DATA AVAILABILITY AND SPECIFIC 4253 02:37:06,374 --> 02:37:08,676 DATA RELEASE NOTES COVERING 4254 02:37:08,676 --> 02:37:11,946 EVERY DOMAIN IN THE ASSESSMENT 4255 02:37:11,946 --> 02:37:12,780 PROTOCOL, AND IMPORTANTLY THESE 4256 02:37:12,780 --> 02:37:16,017 RELEASE NOTES CAN BE UPDATED 4257 02:37:16,017 --> 02:37:16,517 REGULARLY. 4258 02:37:16,517 --> 02:37:18,519 SO IN CONTRAST TO THE PAST 4259 02:37:18,519 --> 02:37:21,155 AVAILABLE ONLY THROUGH THE NIMH 4260 02:37:21,155 --> 02:37:25,760 DATA ARRIVE AS A STATIC DOCUMENT 4261 02:37:25,760 --> 02:37:26,394 THESE ARE DOCUMENTED WITH 4262 02:37:26,394 --> 02:37:29,030 UPDATES SO THE COMMUNITY CAN BE 4263 02:37:29,030 --> 02:37:31,265 INFORMED AS THINGS ARE SHIFTING 4264 02:37:31,265 --> 02:37:31,899 AND CHANGING. 4265 02:37:31,899 --> 02:37:34,502 SO THAT'S ON THE WIKI. 4266 02:37:34,502 --> 02:37:36,704 WE ALSO HAVE NEW WITH THIS DATA 4267 02:37:36,704 --> 02:37:38,239 RELEASE A DATA DICTIONARY 4268 02:37:38,239 --> 02:37:38,973 EXPLORER APPLICATION WHICH I'LL 4269 02:37:38,973 --> 02:37:40,241 SHOW YOU IN JUST A MOMENT. 4270 02:37:40,241 --> 02:37:44,379 AND THIS IS A WAY TO 4271 02:37:44,379 --> 02:37:45,680 INTERACTIVELY EXPLORE THE RICH 4272 02:37:45,680 --> 02:37:47,048 DATA RESOURCE AND UNDERSTAND THE 4273 02:37:47,048 --> 02:37:49,050 FULL EXTENT OF THE CONSTRUCTS 4274 02:37:49,050 --> 02:37:51,619 THAT ARE MEASURED DOWN TO THE 4275 02:37:51,619 --> 02:37:52,220 INDIVIDUAL DATA ELEMENTS 4276 02:37:52,220 --> 02:37:53,888 INCLUDED IN EACH OF THE 4277 02:37:53,888 --> 02:37:57,291 CONSTRUCTS, AND YOU CAN EXPLORE 4278 02:37:57,291 --> 02:37:58,159 THE DATA CONSTRUCTS WITHOUT 4279 02:37:58,159 --> 02:37:59,827 HAVING ACCESS TO THE DATA SO NO 4280 02:37:59,827 --> 02:38:02,897 DATA ARE INCLUDED HERE, JUST THE 4281 02:38:02,897 --> 02:38:04,098 CONSTRUCTS THEMSELVES, I THINK 4282 02:38:04,098 --> 02:38:05,533 REALLY USEFUL FOR FOLKS WHO MAY 4283 02:38:05,533 --> 02:38:07,802 BE NEW TO ABCD AND WANT TO GET 4284 02:38:07,802 --> 02:38:10,004 SORT OF A LANDSCAPE VIEW OF 4285 02:38:10,004 --> 02:38:11,305 WHAT'S CONTAINED IN THIS 4286 02:38:11,305 --> 02:38:11,806 RESOURCE. 4287 02:38:11,806 --> 02:38:13,174 THE LAST THING I WANT TO TELL 4288 02:38:13,174 --> 02:38:17,779 YOU ABOUT ALSO NEW IS A 4289 02:38:17,779 --> 02:38:19,947 DISCUSSION FORUM HOSTED ON A 4290 02:38:19,947 --> 02:38:22,350 REPOSITORY CALLED NOW I KNOW MY 4291 02:38:22,350 --> 02:38:27,622 ABCDs, WHICH IS MANAGED OUT OF 4292 02:38:27,622 --> 02:38:28,990 FLORIDA INTERNATIONAL UNIVERSITY 4293 02:38:28,990 --> 02:38:32,293 BY ANDREA LAIRD, SOME OF HER 4294 02:38:32,293 --> 02:38:35,263 POSTDOCS DEVELOPED THIS FORUM, 4295 02:38:35,263 --> 02:38:36,230 WHICH IS INTERACTIVE AND UP TO 4296 02:38:36,230 --> 02:38:37,999 THE MOMENT SO FOLKS CAN COME IN 4297 02:38:37,999 --> 02:38:40,401 AND ASK QUESTIONS OF ABCD DATA 4298 02:38:40,401 --> 02:38:42,370 AND THE COMMUNITY IS THEN 4299 02:38:42,370 --> 02:38:42,703 RESPONDING. 4300 02:38:42,703 --> 02:38:44,439 SO OTHER USERS CAN THEN WEIGH IN 4301 02:38:44,439 --> 02:38:47,041 ON SOME OF THE QUESTIONS THAT 4302 02:38:47,041 --> 02:38:52,313 ARE ASKED AND WE ALSO HAVE KEVIN 4303 02:38:52,313 --> 02:38:53,648 LYE WHO IS ROUTINELY VISITING 4304 02:38:53,648 --> 02:38:55,383 THE FORUM AS MANY OF US ARE TO 4305 02:38:55,383 --> 02:38:57,351 SEE WHAT KINDS OF QUESTIONS ARE 4306 02:38:57,351 --> 02:38:58,786 BEING ASKED AND WHERE 4307 02:38:58,786 --> 02:39:02,290 APPROPRIATE BRINGING OVER THOSE 4308 02:39:02,290 --> 02:39:04,659 QUESTIONS TO THE WIKI, PROVIDING 4309 02:39:04,659 --> 02:39:05,560 ANSWERS FROM ABCD EXPERTS. 4310 02:39:05,560 --> 02:39:08,830 SO THAT'S SORT OF THAT NICE KIND 4311 02:39:08,830 --> 02:39:10,698 OF INTERACTIVE BACK AND FORTH 4312 02:39:10,698 --> 02:39:12,967 RELATIONSHIP WITH ABCD AN THE 4313 02:39:12,967 --> 02:39:13,367 DISCUSSION FORUM. 4314 02:39:13,367 --> 02:39:15,636 AND THIS IS JUST A QUICK EXAMPLE 4315 02:39:15,636 --> 02:39:18,139 OF WHAT THE WIKI PAGE LOOKS 4316 02:39:18,139 --> 02:39:19,774 LIKE, THIS IS THE MAIN PAGE. 4317 02:39:19,774 --> 02:39:22,844 YOU'LL SEE HERE ON THE LEFT-HAND 4318 02:39:22,844 --> 02:39:25,813 COLUMN THESE ARE INDIVIDUAL 4319 02:39:25,813 --> 02:39:27,215 RELEASE NOTES, ORGANIZED BY 4320 02:39:27,215 --> 02:39:28,015 DOMAIN. 4321 02:39:28,015 --> 02:39:29,884 YOU CAN CLICK ON -- WE'LL 4322 02:39:29,884 --> 02:39:33,488 PRETEND WE'RE WALKING THROUGH 4323 02:39:33,488 --> 02:39:34,055 THIS DYNAMICICALLY. 4324 02:39:34,055 --> 02:39:35,857 IF YOU CLICK ON FOR EXAMPLE 4325 02:39:35,857 --> 02:39:37,191 NEUROCOGNITION IN BLUE, YOU 4326 02:39:37,191 --> 02:39:39,227 WOULD THEN BE BROUGHT TO A LIST 4327 02:39:39,227 --> 02:39:41,262 OF ALL OF THE INSTRUMENTS THAT 4328 02:39:41,262 --> 02:39:42,697 ARE AVAILABLE IN THAT DOMAIN. 4329 02:39:42,697 --> 02:39:47,001 AND THEN IF YOU CLICK ON 4330 02:39:47,001 --> 02:39:47,668 INSTRUMENT, NIH TOOLBOX, FOR 4331 02:39:47,668 --> 02:39:50,471 EXAMPLE, YOU GO TO THE NEXT, 4332 02:39:50,471 --> 02:39:51,672 MANY MORE DETAILS ABOUT THAT 4333 02:39:51,672 --> 02:39:54,408 INSTRUMENT HERE ON THE RIGHT. 4334 02:39:54,408 --> 02:39:58,246 YOU CAN SEE DESCRIPTIONS OF THE 4335 02:39:58,246 --> 02:40:00,548 MEASURE, AND LINKS TO TECHNICAL 4336 02:40:00,548 --> 02:40:02,483 MANUALS, IN SOME CASES RESEARCH 4337 02:40:02,483 --> 02:40:04,018 ARTICLES ABOUT THE USE OF THOSE 4338 02:40:04,018 --> 02:40:04,252 DATA. 4339 02:40:04,252 --> 02:40:05,887 AND THEN IF YOU WERE TO CLICK ON 4340 02:40:05,887 --> 02:40:08,823 THE TABLE NAME WHICH IS THE 4341 02:40:08,823 --> 02:40:10,291 THIRD COLUMN YOU'RE BROUGHT TO 4342 02:40:10,291 --> 02:40:11,826 THE ABCD DATA DICTIONARY THAT I 4343 02:40:11,826 --> 02:40:17,064 MENTIONED EARLIER, A GREAT WAY 4344 02:40:17,064 --> 02:40:20,134 TO INTERACTIVELY LOOK AT THE 4345 02:40:20,134 --> 02:40:22,737 ABCD CONSTRUCTS THROUGH THIS 4346 02:40:22,737 --> 02:40:24,071 TREE STRUCTURE ON THE LEFT 4347 02:40:24,071 --> 02:40:26,374 DRILLING DOWN INTO DOMAINS AND 4348 02:40:26,374 --> 02:40:27,775 INDIVIDUAL INSTRUMENTS OR 4349 02:40:27,775 --> 02:40:29,010 THROUGH A QUERY SEARCH FEATURE 4350 02:40:29,010 --> 02:40:30,745 HERE ON THE RIGHT WHERE YOU CAN 4351 02:40:30,745 --> 02:40:34,348 QUERY THE TABLE NAME, VARIABLE 4352 02:40:34,348 --> 02:40:37,552 NAME, CONSTRUCT, AND THAT WILL 4353 02:40:37,552 --> 02:40:39,053 POP UP WITH INFORMATION. 4354 02:40:39,053 --> 02:40:40,688 NEXT SLIDE. 4355 02:40:40,688 --> 02:40:43,224 AND THE REALLY EXCITING NEWS, 4356 02:40:43,224 --> 02:40:44,859 BEST FOR LAST, AS GAYA 4357 02:40:44,859 --> 02:40:47,395 MENTIONED, A NEW DATA SHARING 4358 02:40:47,395 --> 02:40:49,030 PLATFORM COMING THIS SUMMER. 4359 02:40:49,030 --> 02:40:51,098 AND THIS WILL HOST DATA RELEASE 4360 02:40:51,098 --> 02:40:57,872 6.0, THIS IS ON THE LASSO DATA 4361 02:40:57,872 --> 02:40:59,106 INFORMATICS SYSTEM, ALL DATA ARE 4362 02:40:59,106 --> 02:41:02,343 AT LEAST THE MOST RECENT COUPLE 4363 02:41:02,343 --> 02:41:03,945 RELEASES WILL BE MOVED OVER OH 4364 02:41:03,945 --> 02:41:06,414 ALL DATA USE WILL BE THROUGH THE 4365 02:41:06,414 --> 02:41:10,017 LASSO PLATFORM AND NO LONGER 4366 02:41:10,017 --> 02:41:11,886 THROUGH THE NDA, EXCITING 4367 02:41:11,886 --> 02:41:15,156 BECAUSE IT WILL REALLY BE A 4368 02:41:15,156 --> 02:41:16,457 FLEXIBLE PLATFORM THAT WILL 4369 02:41:16,457 --> 02:41:21,062 ACCOMMODATE USERS WITH DIFFERENT 4370 02:41:21,062 --> 02:41:22,930 LEVELS OF EXPERTISE AND MULTIPLE 4371 02:41:22,930 --> 02:41:24,665 WAYS TO ANALYZE DATA, WILL 4372 02:41:24,665 --> 02:41:26,434 INCLUDE UP THROUGH 50% OF THE 4373 02:41:26,434 --> 02:41:28,402 SIX-YEAR FOLLOW-UP DATA AND MOST 4374 02:41:28,402 --> 02:41:31,138 OF THE FIVE-YEAR FOLLOW-UP DATA. 4375 02:41:31,138 --> 02:41:33,774 IMPORTANTLY, IT WILL BE -- THIS 4376 02:41:33,774 --> 02:41:35,610 WILL EVENTUALLY PROVIDE A 4377 02:41:35,610 --> 02:41:36,711 HOMOGENOUS SOLUTION FOR 4378 02:41:36,711 --> 02:41:39,981 HARMONIZING WITH PLANNED DATA 4379 02:41:39,981 --> 02:41:42,083 FROM HBCD, ONE-STOP SHOPPING FOR 4380 02:41:42,083 --> 02:41:44,585 ALL OF THE DATA AVAILABLE IN 4381 02:41:44,585 --> 02:41:46,120 THESE TWO PROGRAMS, AND HERE 4382 02:41:46,120 --> 02:41:47,855 BELOW IS JUST A HIGH LEVEL DATA 4383 02:41:47,855 --> 02:41:49,757 FLOW OF HOW THIS SYSTEM WILL 4384 02:41:49,757 --> 02:41:50,625 WORK. 4385 02:41:50,625 --> 02:41:53,561 MUCH MORE INFORMATION ABOUT THIS 4386 02:41:53,561 --> 02:41:56,631 COMING SOON, BUT A QUICK SENSE, 4387 02:41:56,631 --> 02:41:59,700 THE LASSO, MAIN LASSO PLATFORM 4388 02:41:59,700 --> 02:42:02,970 WHICH HAS USER-FACING 4389 02:42:02,970 --> 02:42:04,505 FUNCTIONALITY, USER 4390 02:42:04,505 --> 02:42:05,272 AUTHENTICATION PORTAL FOR 4391 02:42:05,272 --> 02:42:07,675 CERTIFICATION TO TAKE PLACE, 4392 02:42:07,675 --> 02:42:09,110 KNOWLEDGE BASE, A QUERY, SEVERAL 4393 02:42:09,110 --> 02:42:12,613 KINDS OF QUERY TOOLS OF THE 4394 02:42:12,613 --> 02:42:14,682 DATA, AND THEN THE FINAL STORED 4395 02:42:14,682 --> 02:42:16,183 AT THE UNIVERSITY OF MINNESOTA, 4396 02:42:16,183 --> 02:42:17,718 LINKAGES OUT TO THE UNIVERSITY 4397 02:42:17,718 --> 02:42:20,921 OF MINNESOTA, WHERE THE DATA 4398 02:42:20,921 --> 02:42:22,223 WILL ACTUALLY BE. 4399 02:42:22,223 --> 02:42:23,424 THE THIRD COMPONENT WHICH SOME 4400 02:42:23,424 --> 02:42:27,028 MAY BE FAMILIAR WITH FROM PAST 4401 02:42:27,028 --> 02:42:28,896 DATA RELEASES IS DATA 4402 02:42:28,896 --> 02:42:30,231 EXPLORATION AND ANALYSIS PORTAL, 4403 02:42:30,231 --> 02:42:32,700 ANOTHER TOOL FOR USERS TO 4404 02:42:32,700 --> 02:42:33,401 ANALYZE THE DATA, TO TAKE 4405 02:42:33,401 --> 02:42:35,503 ADVANTAGE OF SOME OF THE COMPLEX 4406 02:42:35,503 --> 02:42:36,737 MODELING THAT IS INCLUDED IN 4407 02:42:36,737 --> 02:42:39,240 ABCD AND THAT WILL BE AVAILABLE 4408 02:42:39,240 --> 02:42:40,307 AS WELL. 4409 02:42:40,307 --> 02:42:41,709 ALL OF THIS INTRAOPERABILITY 4410 02:42:41,709 --> 02:42:44,478 WILL BE CRITICAL I THINK FOR 4411 02:42:44,478 --> 02:42:45,980 PROVIDING FLEXIBLE WAYS FOR 4412 02:42:45,980 --> 02:42:49,817 USERS TO ACCESS AND USE THE 4413 02:42:49,817 --> 02:42:50,017 DATA. 4414 02:42:50,017 --> 02:42:53,554 THE OTHER THING I WANTED TO 4415 02:42:53,554 --> 02:42:56,123 POINT OUT IS, NEXT SLIDE, A NEW 4416 02:42:56,123 --> 02:42:57,058 TRAINING MODULE THAT WILL BE 4417 02:42:57,058 --> 02:43:01,996 PART OF THIS NEW DATA RELEASE 4418 02:43:01,996 --> 02:43:02,596 PROCEDURE AND MOVING FORWARD, 4419 02:43:02,596 --> 02:43:06,801 AND THIS IS PART OF THE USER 4420 02:43:06,801 --> 02:43:09,203 AUTHENTICATION PART OF THE USER 4421 02:43:09,203 --> 02:43:09,503 EXPERIENCE. 4422 02:43:09,503 --> 02:43:10,805 SO WHEN A USER COMES IN TO 4423 02:43:10,805 --> 02:43:13,708 ACCESS THE DATA, THIS IS ANY 4424 02:43:13,708 --> 02:43:15,109 USER, EVEN SOMEBODY CURRENTLY -- 4425 02:43:15,109 --> 02:43:16,477 WHO HAD A DATA USE AGREEMENT 4426 02:43:16,477 --> 02:43:19,480 WITH THE NDA, THEY WILL COME IN 4427 02:43:19,480 --> 02:43:21,949 AND NEED TO COMPLETE A 4428 02:43:21,949 --> 02:43:23,451 RESPONSIBLE DATA AND BIOSPECIMEN 4429 02:43:23,451 --> 02:43:26,320 USE TRAINING. 4430 02:43:26,320 --> 02:43:27,655 THIS IS A REQUIREMENT, NEED TO 4431 02:43:27,655 --> 02:43:29,924 COMPLETE ASSESSMENT AND PASS 4432 02:43:29,924 --> 02:43:32,226 RATE IS 90% SO WE'RE EXPECTING 4433 02:43:32,226 --> 02:43:34,962 PEOPLE WILL TAKE THIS TRAINING 4434 02:43:34,962 --> 02:43:35,596 SERIOUSLY, GO THROUGH, THEY 4435 02:43:35,596 --> 02:43:37,765 CAN'T SKIP AHEAD, THEY WILL DO 4436 02:43:37,765 --> 02:43:38,966 ASSESSMENT AT THE END TO 4437 02:43:38,966 --> 02:43:40,334 DEMONSTRATE KNOWLEDGE. 4438 02:43:40,334 --> 02:43:41,936 ON THE RIGHT BRIEFLY, HIGH-LEVEL 4439 02:43:41,936 --> 02:43:43,838 TOPICS THAT ARE COVERED IN THIS 4440 02:43:43,838 --> 02:43:45,806 TRAINING MODULE, SO DESCRIPTION 4441 02:43:45,806 --> 02:43:48,743 OF ETHICAL PRINCIPLES FOR DOING 4442 02:43:48,743 --> 02:43:50,511 SECONDARY DATA ANALYSIS, WE 4443 02:43:50,511 --> 02:43:52,179 DON'T ASSUME USERS NECESSARILY 4444 02:43:52,179 --> 02:43:54,081 KNOW ABOUT THIS, DESCRIBING 4445 02:43:54,081 --> 02:43:55,649 HISTORICAL AND CONTEMPORARY 4446 02:43:55,649 --> 02:43:56,650 CONTEXT FOR UNDERSTANDING RACE 4447 02:43:56,650 --> 02:43:58,719 AND RACISM IN SCIENCE AND 4448 02:43:58,719 --> 02:44:00,254 MEDICINE, UNDERSTANDING HOW TO 4449 02:44:00,254 --> 02:44:03,457 CONDUCT SCIENCE ETHICALLY AND 4450 02:44:03,457 --> 02:44:04,458 RESPONSIBLY, INCLUDING 4451 02:44:04,458 --> 02:44:05,526 COMMUNICATING, INTERPRETING THE 4452 02:44:05,526 --> 02:44:06,093 SCIENCE. 4453 02:44:06,093 --> 02:44:08,262 AND UNDERSTANDING THE DATA USE 4454 02:44:08,262 --> 02:44:09,263 TERMS AND CONDITIONS FOR 4455 02:44:09,263 --> 02:44:12,099 ACCESSING DATA AND FOR USING 4456 02:44:12,099 --> 02:44:14,168 BIOSPECIMENS AND HOW TO MITIGATE 4457 02:44:14,168 --> 02:44:15,236 RISK OF PARTICIPANT 4458 02:44:15,236 --> 02:44:16,270 IDENTIFICATION WHICH IS 4459 02:44:16,270 --> 02:44:19,240 ESPECIALLY IMPORTANT NOW THAT WE 4460 02:44:19,240 --> 02:44:21,308 HAVE INCREASING AMOUNTS OF DATA 4461 02:44:21,308 --> 02:44:23,811 AVAILABLE AT ABCD, AND PERHAPS 4462 02:44:23,811 --> 02:44:24,345 MORE OPPORTUNITIES FOR 4463 02:44:24,345 --> 02:44:25,579 TRIANGULATING IF SOMEBODY WERE 4464 02:44:25,579 --> 02:44:28,649 SO INCLINED TO DO THAT. 4465 02:44:28,649 --> 02:44:31,585 THIS HAS NOT BEEN BUILT INTO NDA 4466 02:44:31,585 --> 02:44:32,586 SO WE'RE EXCITED THIS WILL BE 4467 02:44:32,586 --> 02:44:35,689 AVAILABLE AS PART OF THIS NEW 4468 02:44:35,689 --> 02:44:36,857 DATA SHARING PLATFORM. 4469 02:44:36,857 --> 02:44:37,725 AND AS WITH EVERYTHING ELSE MORE 4470 02:44:37,725 --> 02:44:39,827 ON THIS LATER IN THE COMING 4471 02:44:39,827 --> 02:44:41,996 WEEKS AND MONTHS, AS WE RAMP UP. 4472 02:44:41,996 --> 02:44:43,831 SOME FUNCTIONALITY I THINK I 4473 02:44:43,831 --> 02:44:46,033 FORGOT TO MENTION ON THE DATA 4474 02:44:46,033 --> 02:44:47,234 SHARING PLATFORM WON'T BE 4475 02:44:47,234 --> 02:44:55,810 AVAILABLE IMMEDIATELY WITH THE 4476 02:44:55,810 --> 02:44:58,078 ROLLOUT BUT RAMPED UP, AND WE'LL 4477 02:44:58,078 --> 02:44:59,713 KEEP YOU INFORMED ABOUT UPDATES 4478 02:44:59,713 --> 02:45:00,948 AS THEY HAPPEN. 4479 02:45:00,948 --> 02:45:02,249 THAT'S IT FOR ME. 4480 02:45:02,249 --> 02:45:03,317 >> THANKS, ELIZABETH. 4481 02:45:03,317 --> 02:45:07,388 NOW OVER TO KIM LEBLANC TO TALK 4482 02:45:07,388 --> 02:45:14,395 ABOUT OUR BIOSPECIMEN ACCESS 4483 02:45:14,395 --> 02:45:14,628 PROGRAM. 4484 02:45:14,628 --> 02:45:17,464 >> THANK YOU. 4485 02:45:17,464 --> 02:45:22,636 IN ADDITION TO MAKING OUR DATE 4486 02:45:22,636 --> 02:45:25,873 WE'LL MAKE BIOSPECIMENS IDEA. 4487 02:45:25,873 --> 02:45:27,341 THE IDEA WAS FUTURE USE OF THEM. 4488 02:45:27,341 --> 02:45:29,844 YOU CAN SEE WHAT WE COLLECT IN 4489 02:45:29,844 --> 02:45:30,511 THE BOTTOM RIGHT. 4490 02:45:30,511 --> 02:45:32,346 SOME OF THESE ALREADY GO FOR 4491 02:45:32,346 --> 02:45:34,315 SOME PRE-DETERMINED ANALYSES 4492 02:45:34,315 --> 02:45:35,850 PART OF OUR PROTOCOL BUT THE 4493 02:45:35,850 --> 02:45:37,918 REST REMAIN AVAILABLE FOR 4494 02:45:37,918 --> 02:45:38,686 ADDITIONAL STUDY. 4495 02:45:38,686 --> 02:45:40,688 SO WE'RE NOW STARTING THIS 4496 02:45:40,688 --> 02:45:44,391 ACCESS PROGRAM TO ALLOW ABCD 4497 02:45:44,391 --> 02:45:46,493 CONSORTIUM INVESTIGATORS AND THE 4498 02:45:46,493 --> 02:45:48,128 ENTIRE SCIENTIFIC COMMUNITY TO 4499 02:45:48,128 --> 02:45:49,864 APPLY TO USE THEM. 4500 02:45:49,864 --> 02:45:53,267 THE IDEA IS TO EXPAND THE 4501 02:45:53,267 --> 02:45:55,135 SCIENTIFIC RESEARCH WORK DONE ON 4502 02:45:55,135 --> 02:45:56,203 ADOLESCENTS TO EXPAND WHAT WE 4503 02:45:56,203 --> 02:45:59,940 HAVE GETTING FROM THE ABCD STUDY 4504 02:45:59,940 --> 02:46:01,141 AND OUR KNOWLEDGE ABOUT HEALTH 4505 02:46:01,141 --> 02:46:02,810 MORE GENERALLY. 4506 02:46:02,810 --> 02:46:09,683 THEY HAVE TO DEPOSIT RESULTS OF 4507 02:46:09,683 --> 02:46:11,552 ANALYSES FURTHER ENRICHING ALL 4508 02:46:11,552 --> 02:46:19,627 THE DATA, THROUGH AN X01 4509 02:46:19,627 --> 02:46:20,928 RESOURCE ACCESS AWARDS, THEY 4510 02:46:20,928 --> 02:46:23,030 HAVE TO GET THEIR OWN FUNDS TO 4511 02:46:23,030 --> 02:46:23,797 DO THE ANALYSES. 4512 02:46:23,797 --> 02:46:25,766 DEMONSTRATION OF THE PROCESS FOR 4513 02:46:25,766 --> 02:46:26,867 APPLYING, MOSTLY TO SHOW A LOT 4514 02:46:26,867 --> 02:46:28,369 OF TOOLS ARE AVAILABLE THAT I'LL 4515 02:46:28,369 --> 02:46:30,037 WALK THROUGH IN JUST A MOMENT TO 4516 02:46:30,037 --> 02:46:32,439 HELP RESEARCHERS FIGURE OUT WHAT 4517 02:46:32,439 --> 02:46:34,642 WE HAVE AVAILABLE, WHAT SUITS 4518 02:46:34,642 --> 02:46:35,409 THEIR NEEDS, WHETHER IT MEETS 4519 02:46:35,409 --> 02:46:37,044 WHAT THEY ARE TRYING TO STUDY 4520 02:46:37,044 --> 02:46:38,112 AND GOES ALONG WITH OTHER DATA 4521 02:46:38,112 --> 02:46:40,547 THEY ARE TRYING TO LOOK AT FROM 4522 02:46:40,547 --> 02:46:43,050 ABCD STUDY PARTICIPANTS. 4523 02:46:43,050 --> 02:46:44,852 AND IMPORTANTLY THEY HAVE TO DO 4524 02:46:44,852 --> 02:46:45,586 AVAILABILITY INQUIRY TO SEE 4525 02:46:45,586 --> 02:46:47,755 WHAT'S AVAILABLE AND PART OF 4526 02:46:47,755 --> 02:46:50,291 THAT GET BACK THE RESOURCE 4527 02:46:50,291 --> 02:46:51,792 AVAILABILITY AND IMPACT REPORT, 4528 02:46:51,792 --> 02:46:52,993 SHOWING HOW MUCH WHAT THEIR 4529 02:46:52,993 --> 02:46:54,428 ASKING FOR WILL DEPLETE WHAT WE 4530 02:46:54,428 --> 02:46:55,596 HAVE REMAINING. 4531 02:46:55,596 --> 02:46:57,398 WE'LL BE ABLE TO CAREFULLY 4532 02:46:57,398 --> 02:46:58,799 ASSESS WHAT PEOPLE ARE ASKING TO 4533 02:46:58,799 --> 02:47:02,202 DO AND MAKE SURE THE SCIENTIFIC 4534 02:47:02,202 --> 02:47:03,304 VALUE OF WHAT THEY ARE ASKING TO 4535 02:47:03,304 --> 02:47:04,605 DO MEETS HOW MUCH THEY ARE GOING 4536 02:47:04,605 --> 02:47:07,241 TO BE DEPLETING WHAT WE HAVE 4537 02:47:07,241 --> 02:47:12,613 LEFT. 4538 02:47:12,613 --> 02:47:14,915 SO HERE A BRIEF PSEUDOTOUR, ALSO 4539 02:47:14,915 --> 02:47:16,784 A QR CODE THERE IF YOU WANT TO 4540 02:47:16,784 --> 02:47:19,053 TAKE A LOOK FOR IT YOURSELF. 4541 02:47:19,053 --> 02:47:20,487 THERE'S A NUMBER OF TOOLS 4542 02:47:20,487 --> 02:47:20,754 AVAILABLE. 4543 02:47:20,754 --> 02:47:21,822 FIRST IS KIND OF WALKING THROUGH 4544 02:47:21,822 --> 02:47:23,757 WHAT I JUST DID FOR YOU THERE, 4545 02:47:23,757 --> 02:47:25,092 THE PROCESS OF APPLYING SO 4546 02:47:25,092 --> 02:47:26,493 PEOPLE WITH CLICK THROUGH, SEE 4547 02:47:26,493 --> 02:47:28,162 HOW THE PROCESS IS SUPPOSED TO 4548 02:47:28,162 --> 02:47:30,130 WORK, ADDITIONAL DETAILS ON WHAT 4549 02:47:30,130 --> 02:47:31,632 THEY NEED TO KNOW. 4550 02:47:31,632 --> 02:47:33,667 HERE'S A SNAPSHOT OF THE 4551 02:47:33,667 --> 02:47:34,835 RESEARCHER GUIDES, ALL SORTS OF 4552 02:47:34,835 --> 02:47:38,005 DETAILS ON HOW THINGS ARE 4553 02:47:38,005 --> 02:47:39,673 COLLECTED, STORED, PROCESSED, 4554 02:47:39,673 --> 02:47:41,508 WHAT SORT OF AMOUNTS THEY MIGHT 4555 02:47:41,508 --> 02:47:42,943 WANT TO USE FOR ANALYSIS TO 4556 02:47:42,943 --> 02:47:47,214 FIGURE OUT IF WE HAVE WHAT THEY 4557 02:47:47,214 --> 02:47:47,414 NEED. 4558 02:47:47,414 --> 02:47:49,750 WE HAVE THIS NICE TOOL, 4559 02:47:49,750 --> 02:47:50,851 BIOSPECIMEN EXPLORER TOOL. 4560 02:47:50,851 --> 02:47:52,920 PEOPLE WITH GO IN AND FILTER 4561 02:47:52,920 --> 02:47:54,655 WHAT WE HAVE AVAILABLE BASED ON 4562 02:47:54,655 --> 02:47:57,925 TIME POINTS OF INTEREST, 4563 02:47:57,925 --> 02:47:59,226 BIOSPECIMEN TYPES, DEMOGRAPHIC 4564 02:47:59,226 --> 02:47:59,927 FEATURES, WE'RE ADDING SAMPLE 4565 02:47:59,927 --> 02:48:04,498 CONDITIONS, BEING ABLE TO SEARCH 4566 02:48:04,498 --> 02:48:06,033 BY PARTICIPANT I.D.s TO MAKE 4567 02:48:06,033 --> 02:48:07,668 SURE IT MATCHES OTHER DATA FOR 4568 02:48:07,668 --> 02:48:08,635 CERTAIN PARTICIPANTS. 4569 02:48:08,635 --> 02:48:09,603 WHAT YOU'LL GET BACK IMMEDIATELY 4570 02:48:09,603 --> 02:48:11,839 IS NUMBER OF PARTICIPANTS IN 4571 02:48:11,839 --> 02:48:12,906 THESE DIFFERENT CATEGORIES THAT 4572 02:48:12,906 --> 02:48:15,209 HAVE SPECIMENS AT THOSE TIME 4573 02:48:15,209 --> 02:48:15,442 POINTS. 4574 02:48:15,442 --> 02:48:16,977 AGAIN, IF IT DOES MEET THEIR 4575 02:48:16,977 --> 02:48:18,479 NEEDS THEY CAN START INQUIRY AND 4576 02:48:18,479 --> 02:48:22,449 GET THAT REPORT BACK HOW MUCH OF 4577 02:48:22,449 --> 02:48:23,650 IT'S GOING TO DEPLETE RESOURCES, 4578 02:48:23,650 --> 02:48:24,685 WE'LL SEE THE APPLICATION TO 4579 02:48:24,685 --> 02:48:28,122 MAKE SURE IT'S A GOOD USE OF THE 4580 02:48:28,122 --> 02:48:28,389 RESOURCES. 4581 02:48:28,389 --> 02:48:30,290 THERE'S MORE INFORMATION ON OUR 4582 02:48:30,290 --> 02:48:32,292 WEBSITE, MOSTLY MORE ABOUT THE 4583 02:48:32,292 --> 02:48:34,995 PROCESS FOR APPLYING. 4584 02:48:34,995 --> 02:48:36,964 AND IT'S ACTIVE RIGHT NOW. 4585 02:48:36,964 --> 02:48:38,632 HERE ARE UPCOMING DATES, THREE 4586 02:48:38,632 --> 02:48:40,034 CYCLES, MORE DATES COMING FOR 4587 02:48:40,034 --> 02:48:40,701 THIS. 4588 02:48:40,701 --> 02:48:42,770 WE'VE ALREADY HAD ONE 4589 02:48:42,770 --> 02:48:44,071 APPLICATION, NUMEROUS 4590 02:48:44,071 --> 02:48:45,372 AVAILABILITY INQUIRIES SO WE'RE 4591 02:48:45,372 --> 02:48:46,173 EXCITED TO ADD THIS TO THE 4592 02:48:46,173 --> 02:48:47,174 REPERTOIRE OF ALL THE GREAT 4593 02:48:47,174 --> 02:48:48,909 THINGS PEOPLE CAN BE DOING WITH 4594 02:48:48,909 --> 02:48:51,979 THE ABCD STUDY TO ALSO START 4595 02:48:51,979 --> 02:48:52,746 ANALYZING OUR BIOSPECIMENS AND 4596 02:48:52,746 --> 02:48:54,848 ADDING THAT DATA BACK INTO THE 4597 02:48:54,848 --> 02:49:02,022 DATA RESOURCE. 4598 02:49:02,022 --> 02:49:02,689 >> THANKS, KIM. 4599 02:49:02,689 --> 02:49:05,325 I AS LIKE TO END THIS 4600 02:49:05,325 --> 02:49:06,627 PRESENTATION TALKING ABOUT WHAT 4601 02:49:06,627 --> 02:49:09,696 IS COMING OUT OF ABCD. 4602 02:49:09,696 --> 02:49:12,332 I WANT TO START, AND THESE 4603 02:49:12,332 --> 02:49:14,301 ANALYSES WERE DONE BY DIANA 4604 02:49:14,301 --> 02:49:15,502 ALKIRE, WITH THE NUMBER OF 4605 02:49:15,502 --> 02:49:19,673 GRANTS FUNDED TO USE ABCD DATA, 4606 02:49:19,673 --> 02:49:21,642 MORE THAN 200 GRANTS FUNDED TO 4607 02:49:21,642 --> 02:49:22,443 USE THE DATA. 4608 02:49:22,443 --> 02:49:24,545 FY 24 IS SMALL BECAUSE WE'RE NOT 4609 02:49:24,545 --> 02:49:26,814 THROUGH WITH FY 24 YET. 4610 02:49:26,814 --> 02:49:28,682 MOST OF THESE ARE RESEARCH 4611 02:49:28,682 --> 02:49:30,084 PROJECT GRANTS, INDIVIDUAL 4612 02:49:30,084 --> 02:49:30,517 TRAINING GRANTS. 4613 02:49:30,517 --> 02:49:33,253 BUT THERE ARE ALSO SOME 4614 02:49:33,253 --> 02:49:34,588 EDUCATION GRANTS, WHICH IS 4615 02:49:34,588 --> 02:49:37,925 IMPORTANT BECAUSE IT'S A WAY TO 4616 02:49:37,925 --> 02:49:40,928 DISSEMINATE ABCD TO THE BROADER 4617 02:49:40,928 --> 02:49:42,896 SCIENTIFIC COMMUNITY. 4618 02:49:42,896 --> 02:49:44,798 AND YOU'LL SEE IN PINK SHE 4619 02:49:44,798 --> 02:49:47,601 SEPARATED OUT THE GRANTS THAT 4620 02:49:47,601 --> 02:49:49,002 HAVE BEEN AWARDED TO PEOPLE PART 4621 02:49:49,002 --> 02:49:52,005 OF THE CONSORTIUM SO THAT WOULD 4622 02:49:52,005 --> 02:49:54,108 BE IN THE GREEN OR BLACK VERSUS 4623 02:49:54,108 --> 02:49:55,509 THOSE NOT PART OF THE 4624 02:49:55,509 --> 02:49:57,611 CONSORTIUM, SO YOU CAN SEE THE 4625 02:49:57,611 --> 02:49:59,146 DATA IS BEING USED BY MANY 4626 02:49:59,146 --> 02:50:00,180 OUTSIDE OF THE CONSORTIUM. 4627 02:50:00,180 --> 02:50:01,748 I THINK ONE OF THE THINGS THAT'S 4628 02:50:01,748 --> 02:50:05,252 BEEN EXCITING FOR ME IS TO SEE 4629 02:50:05,252 --> 02:50:07,988 THAT THE INSTITUTES AND CENTERS 4630 02:50:07,988 --> 02:50:10,491 SUPPORTING THESE GRANTS, SO WE 4631 02:50:10,491 --> 02:50:16,964 HAVE 10 INSTITUTES AND CENTERS 4632 02:50:16,964 --> 02:50:20,134 THAT SUPPORT THE ABCD 4633 02:50:20,134 --> 02:50:21,568 CONSORTIUM, BY 15 INSTITUTES, 4634 02:50:21,568 --> 02:50:23,637 PEOPLE ARE LOOKING AT THINGS WE 4635 02:50:23,637 --> 02:50:25,839 HADN'T THOUGHT OF, OF VALUE TO 4636 02:50:25,839 --> 02:50:30,144 OTHER I.C.s AT NIH AND FUNDING 4637 02:50:30,144 --> 02:50:31,111 FROM NON-NIH ORGANIZATIONS, AS 4638 02:50:31,111 --> 02:50:31,645 WELL. 4639 02:50:31,645 --> 02:50:34,047 ONE THING WE WANTED TO LOOK AT 4640 02:50:34,047 --> 02:50:35,716 THIS YEAR WAS WHAT THE CONTENT 4641 02:50:35,716 --> 02:50:38,085 OF THESE GRANTS ARE. 4642 02:50:38,085 --> 02:50:41,388 SO, DIANA DID ANALYSIS LOOKING 4643 02:50:41,388 --> 02:50:42,956 AT THE PRIMARY FOCUS OF THE 4644 02:50:42,956 --> 02:50:45,893 GRANTS AND THEY ARE ORGANIZED BY 4645 02:50:45,893 --> 02:50:47,661 DOMAIN AS WE DESCRIBED THEM 4646 02:50:47,661 --> 02:50:48,529 THROUGH OUR WORK GROUP 4647 02:50:48,529 --> 02:50:51,031 STRUCTURES. 4648 02:50:51,031 --> 02:50:51,698 YOU CAN SEE NEUROIMAGING AND 4649 02:50:51,698 --> 02:50:53,000 MENTAL HEALTH HAS THE LARGEST 4650 02:50:53,000 --> 02:50:54,968 NUMBER OF GRANTS IN THOSE AREAS. 4651 02:50:54,968 --> 02:50:56,603 YOU CAN SEE ON PREVIOUS SLIDE 4652 02:50:56,603 --> 02:50:58,805 NIMH IS FUNDING THE MOST GRANTS 4653 02:50:58,805 --> 02:51:00,174 USING ABCD DATA. 4654 02:51:00,174 --> 02:51:02,409 BUT I THINK WHAT'S INTERESTING 4655 02:51:02,409 --> 02:51:04,478 IS TO LOOK AT CROSS-CUTTING. 4656 02:51:04,478 --> 02:51:06,813 EACH OF THESE BARS IS FOR 4657 02:51:06,813 --> 02:51:08,549 EXAMPLE FIRST BAR IS OUT OF THE 4658 02:51:08,549 --> 02:51:09,583 NEUROIMAGING GRANT, WHAT OTHER 4659 02:51:09,583 --> 02:51:11,251 DOMAINS ARE THEY LOOKING AT? 4660 02:51:11,251 --> 02:51:14,354 YOU CAN SEE THAT PEOPLE ARE 4661 02:51:14,354 --> 02:51:15,889 PULLING DATA ACROSS DOMAINS TO 4662 02:51:15,889 --> 02:51:18,192 ANSWER THEIR QUESTIONS. 4663 02:51:18,192 --> 02:51:22,696 AND AS A RESULT, WE HAVE -- THIS 4664 02:51:22,696 --> 02:51:25,866 IS 972 BUT DIANA TOLD ME YET 4665 02:51:25,866 --> 02:51:27,501 WE'RE AT 986, RAPIDLY 4666 02:51:27,501 --> 02:51:29,269 APPROACHING 1,000 PAPERS COMING 4667 02:51:29,269 --> 02:51:32,306 OUT OF ABCD WHICH IS REALLY 4668 02:51:32,306 --> 02:51:32,573 EXCITING. 4669 02:51:32,573 --> 02:51:35,709 AND IF YOU LOOK AT THE -- THIS 4670 02:51:35,709 --> 02:51:37,578 IS JUST THE EMPIRICAL PAPERS, NO 4671 02:51:37,578 --> 02:51:38,545 COMMENTARIES OR REVIEWS, YOU 4672 02:51:38,545 --> 02:51:41,615 LOOK AT THE BREAKDOWN BETWEEN 4673 02:51:41,615 --> 02:51:44,351 ABCD AUTHORS THAT ARE MEMBERS OR 4674 02:51:44,351 --> 02:51:45,552 FORMER MEMBERS VERSUS NOT, 60% 4675 02:51:45,552 --> 02:51:47,621 OF THE PAPERS COMING OUT ARE BY 4676 02:51:47,621 --> 02:51:48,956 PEOPLE WHO ARE NOT AFFILIATED 4677 02:51:48,956 --> 02:51:52,526 WITH THE ABCD CONSORTIUM, 4678 02:51:52,526 --> 02:51:54,228 EXCITING TO SEE AS WELL. 4679 02:51:54,228 --> 02:51:57,030 WE'RE STARTING TO LOOK AT OTHER 4680 02:51:57,030 --> 02:51:59,566 METRICS OF IMPACT, SO HERE YOU 4681 02:51:59,566 --> 02:52:04,137 CAN SEE AN ANALYSIS OF THE ABCD 4682 02:52:04,137 --> 02:52:04,972 PUBLICATIONS USING RELATIVE 4683 02:52:04,972 --> 02:52:06,673 CITATION RATIO, WHICH IS A WAY 4684 02:52:06,673 --> 02:52:09,176 TO LOOK AT CITATIONS OF THE 4685 02:52:09,176 --> 02:52:11,245 PAPER NORMALIZED BY FIELD, YEAR, 4686 02:52:11,245 --> 02:52:13,013 NIH-FUNDED PAPERS. 4687 02:52:13,013 --> 02:52:14,514 SO THAT THE MEAN NIH-FUNDED 4688 02:52:14,514 --> 02:52:17,951 PAPER IS 1, AND WHAT YOU SEE 4689 02:52:17,951 --> 02:52:22,756 HERE IS THAT THE AVERAGE RCR FOR 4690 02:52:22,756 --> 02:52:23,857 ABCD PAPERS RANGES BETWEEN 2.5 4691 02:52:23,857 --> 02:52:26,526 TO 7 TIMES THE CITATIONS OF THE 4692 02:52:26,526 --> 02:52:27,427 AVERAGE NIH-FUNDED PAPER. 4693 02:52:27,427 --> 02:52:28,929 SO THAT'S REALLY EXCITING TO SEE 4694 02:52:28,929 --> 02:52:29,596 AS WELL. 4695 02:52:29,596 --> 02:52:32,332 BUT IT IS ONLY ONE MEASURE. 4696 02:52:32,332 --> 02:52:33,634 IT'S REALLY ONLY ONE AUDIENCE, 4697 02:52:33,634 --> 02:52:34,601 TALKING ABOUT THE SCIENTIFIC 4698 02:52:34,601 --> 02:52:36,603 AUDIENCE. 4699 02:52:36,603 --> 02:52:38,672 SO WE'RE ALSO USING ALT METRIC 4700 02:52:38,672 --> 02:52:43,710 TO SEE WHAT THE CONVERSATION IS 4701 02:52:43,710 --> 02:52:46,013 IN OTHER SPACES, AROUND ABCD 4702 02:52:46,013 --> 02:52:46,546 DATA. 4703 02:52:46,546 --> 02:52:48,849 THE MOST MENTIONS HERE ARE 4704 02:52:48,849 --> 02:52:50,350 THROUGH TWITTER, OR X, WHERE 4705 02:52:50,350 --> 02:52:52,886 THERE ARE QUITE A FEW, 29,000 OR 4706 02:52:52,886 --> 02:52:53,053 SO. 4707 02:52:53,053 --> 02:52:54,988 BUT THERE ARE A LOT OF OTHER 4708 02:52:54,988 --> 02:52:57,591 AREAS THAT ARE MENTIONED. 4709 02:52:57,591 --> 02:52:59,059 SO THERE'S NEWS STORIES, BLOGS, 4710 02:52:59,059 --> 02:53:01,995 OTHER TYPES OF SOCIAL MEDIA, AND 4711 02:53:01,995 --> 02:53:04,498 REALLY OF INTEREST IS SEVERAL 4712 02:53:04,498 --> 02:53:06,300 POLICY DOCUMENTS NOW THAT ARE 4713 02:53:06,300 --> 02:53:09,536 STARTING TO CITE ABCD DATA. 4714 02:53:09,536 --> 02:53:10,871 SO, BECAUSE OF ALL THIS GREAT 4715 02:53:10,871 --> 02:53:12,939 WORK THAT IS HAPPENING WITH ABCD 4716 02:53:12,939 --> 02:53:16,209 DATA, WE WANTED TO FIND A WAY TO 4717 02:53:16,209 --> 02:53:18,278 SHOWCASE IT. 4718 02:53:18,278 --> 02:53:21,248 SO PRESENTATIONS OF ABCD DATA, 4719 02:53:21,248 --> 02:53:23,050 MANY CONFERENCES THROUGHOUT THE 4720 02:53:23,050 --> 02:53:24,651 YEAR, THEY TEND TO BE FOCUS, 4721 02:53:24,651 --> 02:53:25,719 NONE SHOW BREADTH OF THE 4722 02:53:25,719 --> 02:53:27,587 RESEARCH THAT'S BEING DONE WITH 4723 02:53:27,587 --> 02:53:28,255 ABCD DATA. 4724 02:53:28,255 --> 02:53:32,292 SO, IN MARCH WE HELD OUR FIRST 4725 02:53:32,292 --> 02:53:33,293 ABCD INSIGHTS AND INNOVATIONS 4726 02:53:33,293 --> 02:53:35,262 MEETING, AND THIS WAS LED BY 4727 02:53:35,262 --> 02:53:38,332 TRACY MURRAY, WHO DID A 4728 02:53:38,332 --> 02:53:41,702 PHENOMENAL JOB ORGANIZING THIS 4729 02:53:41,702 --> 02:53:45,205 MEETING, SUPPORTED BY NIDA, 4730 02:53:45,205 --> 02:53:46,306 NIAAA, NIMH, OBSSR, NICHD, IF 4731 02:53:46,306 --> 02:53:48,275 YOU CLICK ON THE QR CODE WE HAVE 4732 02:53:48,275 --> 02:53:50,243 RECORDINGS OF ALL THE 4733 02:53:50,243 --> 02:53:51,011 PRESENTATIONS ON THE WEBSITE. 4734 02:53:51,011 --> 02:53:53,647 IT WAS REALLY AN EXCITING 4735 02:53:53,647 --> 02:53:54,348 MEETING. 4736 02:53:54,348 --> 02:53:56,283 WE HAD OVER 400 ATTENDEES, IN 4737 02:53:56,283 --> 02:53:57,284 PERSON AND VIRTUALLY. 4738 02:53:57,284 --> 02:54:00,087 AND 90% OF THEM WERE FROM 4739 02:54:00,087 --> 02:54:02,823 OUTSIDE THE ABCD CONSORTIUM. 4740 02:54:02,823 --> 02:54:05,926 WE ALSO RECEIVED 171 ABSTRACTS 4741 02:54:05,926 --> 02:54:07,661 THAT WERE -- MOST TURNED INTO 4742 02:54:07,661 --> 02:54:08,762 POSTERS AT THE MEETING, WE 4743 02:54:08,762 --> 02:54:10,497 SELECTED FROM THOSE THE BEST TO 4744 02:54:10,497 --> 02:54:13,467 GIVE FLASH TALKS DURING THE 4745 02:54:13,467 --> 02:54:14,668 MEETINGS AND WANTED TO 4746 02:54:14,668 --> 02:54:15,302 PRIORITIZE EARLY-STAGE 4747 02:54:15,302 --> 02:54:17,304 INVESTIGATORS AT THIS MEETING SO 4748 02:54:17,304 --> 02:54:18,472 WE CREATED OPPORTUNITIES FOR 4749 02:54:18,472 --> 02:54:21,007 THEM, IN ADDITION TO POSTERS AND 4750 02:54:21,007 --> 02:54:22,542 FLASH TALKS, TO HAVE SOME 4751 02:54:22,542 --> 02:54:23,210 MENTORING OPPORTUNITIES. 4752 02:54:23,210 --> 02:54:25,212 SO WE HAD SOME GROUP SESSIONS. 4753 02:54:25,212 --> 02:54:26,446 THEY WERE ABLE TO IMMEDIATE WITH 4754 02:54:26,446 --> 02:54:27,247 PROGRAM OFFICIALS. 4755 02:54:27,247 --> 02:54:29,750 BUT WE ALSO WERE ABLE TO ARRANGE 4756 02:54:29,750 --> 02:54:30,450 ONE-ON-ONE MENTORING SESSIONS IF 4757 02:54:30,450 --> 02:54:31,952 THERE WERE PARTICULAR AREAS THEY 4758 02:54:31,952 --> 02:54:33,120 WERE INTERESTED IN, PARTICULAR 4759 02:54:33,120 --> 02:54:34,788 PEOPLE THEY WANTED TO TALK TO. 4760 02:54:34,788 --> 02:54:37,724 AND THEN WE ALSO HAD A LUNCH 4761 02:54:37,724 --> 02:54:40,594 SESSION WHERE WE HAD EXPERTS 4762 02:54:40,594 --> 02:54:42,629 FROM THE ABCD CONSORTIUM 4763 02:54:42,629 --> 02:54:44,097 AVAILABLE FOR PARTICIPANTS IN 4764 02:54:44,097 --> 02:54:46,299 THE MEETING TO ASK QUESTIONS 4765 02:54:46,299 --> 02:54:49,136 ABOUT THE DATASETS SO WE HAD 4766 02:54:49,136 --> 02:54:51,004 SUSAN PAPER WHO OVERSEES OUR 4767 02:54:51,004 --> 02:54:52,105 ASSESSMENT PROTOCOLS WAS THERE 4768 02:54:52,105 --> 02:54:53,874 TO ANSWER ANY QUESTIONS THEY HAD 4769 02:54:53,874 --> 02:54:55,909 ABOUT THE ASSESSMENT PROTOCOLS. 4770 02:54:55,909 --> 02:54:59,246 DAMIAN WAS THERE TO ANSWER ABOUT 4771 02:54:59,246 --> 02:55:01,281 IMAGING, WES THOMPSON TO ANSWER 4772 02:55:01,281 --> 02:55:02,482 STATISTICS, SO PEOPLE COULD GET 4773 02:55:02,482 --> 02:55:03,483 IMMEDIATE INFORMATION FROM THE 4774 02:55:03,483 --> 02:55:05,752 EXPERTS IN THE ROOM WHICH WAS 4775 02:55:05,752 --> 02:55:06,453 REALLY EXCITING. 4776 02:55:06,453 --> 02:55:10,357 AND RESULTING FROM THAT WE GOT 4777 02:55:10,357 --> 02:55:12,359 GREAT FEEDBACK. 4778 02:55:12,359 --> 02:55:14,628 I ENJOYED THIS MORE THAN ANY 4779 02:55:14,628 --> 02:55:15,862 OTHER MEETING I CAN REMEMBER, 4780 02:55:15,862 --> 02:55:17,364 AND THEY HOPED THIS WOULD BE THE 4781 02:55:17,364 --> 02:55:18,732 FIRST OF MANY MEETINGS, WHICH SO 4782 02:55:18,732 --> 02:55:19,099 DO WE. 4783 02:55:19,099 --> 02:55:21,401 I THINK IT WAS A UNIQUE 4784 02:55:21,401 --> 02:55:21,701 ENVIRONMENT. 4785 02:55:21,701 --> 02:55:23,804 PEOPLE TOLD ME PARTICULARLY THE 4786 02:55:23,804 --> 02:55:24,604 YOUNGER FOLKS TOLD ME THAT IT 4787 02:55:24,604 --> 02:55:30,377 WAS GREAT TO BE IN A ROOM WHERE 4788 02:55:30,377 --> 02:55:34,881 EVERYBODY WAS USING ABCD, PEOPLE 4789 02:55:34,881 --> 02:55:36,750 WERE WERE THERE TO HELP AND 4790 02:55:36,750 --> 02:55:37,818 GUIDE THEM, A FUN EXPERIENCE. 4791 02:55:37,818 --> 02:55:41,121 ON THE OTHER SIDE IN TERMS OF 4792 02:55:41,121 --> 02:55:42,155 DISSEMINATION WE'VE ALSO MADE IT 4793 02:55:42,155 --> 02:55:45,392 A PRIORITY IN THE LAST YEAR TO 4794 02:55:45,392 --> 02:55:48,795 TAKE THE FINDINGS COMING OUT OF 4795 02:55:48,795 --> 02:55:50,664 ABCD, SYNTHESIZE THEM AND 4796 02:55:50,664 --> 02:55:52,299 PRODUCE INFOGRAPHICS THAT CAN 4797 02:55:52,299 --> 02:55:53,934 TRANSLATE THAT INFORMATION FOR 4798 02:55:53,934 --> 02:55:54,501 THE LAY AUDIENCES, REALLY 4799 02:55:54,501 --> 02:55:56,436 DESIGNED TO BE ABLE TO GIVE BACK 4800 02:55:56,436 --> 02:55:57,771 TO OUR PARTICIPANTS AND THEIR 4801 02:55:57,771 --> 02:55:59,239 FAMILIES SO THEY KNOW WHAT IS 4802 02:55:59,239 --> 02:56:01,074 COMING OUT OF THEIR IMMENSE 4803 02:56:01,074 --> 02:56:03,677 CONTRIBUTION TO THE STUDY. 4804 02:56:03,677 --> 02:56:09,583 SO WE STARTED WITH SCREEN USE 4805 02:56:09,583 --> 02:56:12,385 AND SLEEP COORDINATED BY 4806 02:56:12,385 --> 02:56:13,520 ELIZABETH HOFFMAN, RECENTLY ON 4807 02:56:13,520 --> 02:56:16,056 THE COVID-19 PANDEMIC. 4808 02:56:16,056 --> 02:56:18,024 THE SLEEP INFOGRAPHIC HAS WON 4809 02:56:18,024 --> 02:56:19,226 AWARDS FOR PLAIN LANGUAGE 4810 02:56:19,226 --> 02:56:19,893 DISSEMINATION. 4811 02:56:19,893 --> 02:56:22,729 IN ADDITION TO THE INFOGRAPHICS, 4812 02:56:22,729 --> 02:56:24,564 IN CONJUNCTION WITH EACH 4813 02:56:24,564 --> 02:56:27,100 INFOGRAPHIC WE'VE HERALD A 4814 02:56:27,100 --> 02:56:30,270 WEBINAR WHERE WE INVITE THREE OF 4815 02:56:30,270 --> 02:56:31,938 THE AUTHORS OF PAPERS THAT ARE 4816 02:56:31,938 --> 02:56:34,207 CITED IN THE INFOGRAPHIC TO GIVE 4817 02:56:34,207 --> 02:56:35,842 A SHORT PRESENTATION OF THEIR 4818 02:56:35,842 --> 02:56:37,711 FINDINGS, AND THEN WE HAVE ABOUT 4819 02:56:37,711 --> 02:56:38,912 A HALF HOUR FOR QUESTION AND 4820 02:56:38,912 --> 02:56:40,680 ANSWER FROM THE AUDIENCE, SO 4821 02:56:40,680 --> 02:56:41,715 THIS HAS BEEN EXCITING. 4822 02:56:41,715 --> 02:56:43,183 PEOPLE HAVE SO MANY QUESTIONS, 4823 02:56:43,183 --> 02:56:44,818 THE OPPORTUNITY TO BE ABLE TO 4824 02:56:44,818 --> 02:56:46,453 ASK EXPERTS THAT ARE 4825 02:56:46,453 --> 02:56:47,120 CONTRIBUTING TO THESE 4826 02:56:47,120 --> 02:56:48,455 INFOGRAPHICS HAS BEEN REALLY 4827 02:56:48,455 --> 02:56:49,756 WONDERFUL FOR THEM. 4828 02:56:49,756 --> 02:56:51,825 AND LAST THING I WANT TO MENTION 4829 02:56:51,825 --> 02:56:55,428 AS I SAID WE'RE STARTING TO SEE 4830 02:56:55,428 --> 02:56:57,197 ABCD PAPERS CITED IN POLICY 4831 02:56:57,197 --> 02:57:00,367 DOCUMENTS, I THINK THAT IS 4832 02:57:00,367 --> 02:57:01,568 REALLY IMPORTANT, REALLY 4833 02:57:01,568 --> 02:57:02,669 IMPORTANT VENUE FOR BEING ABLE 4834 02:57:02,669 --> 02:57:04,671 TO USE THE RESULTS OF ABCD DATA 4835 02:57:04,671 --> 02:57:06,439 TO CHANGE THE LIVES OF 4836 02:57:06,439 --> 02:57:08,608 ADOLESCENTS, SO HERE YOU SEE A 4837 02:57:08,608 --> 02:57:09,910 COUPLE EXAMPLES, THERE WAS A 4838 02:57:09,910 --> 02:57:11,778 PAPER THAT CAME OUT LOOKING AT 4839 02:57:11,778 --> 02:57:13,079 SUBSTANCE USE DURING THE 4840 02:57:13,079 --> 02:57:15,615 PANDEMIC, AND IT'S BEEN CITED BY 4841 02:57:15,615 --> 02:57:17,350 THE URBAN INSTITUTE. 4842 02:57:17,350 --> 02:57:20,687 A PAPER A BRAIN CHARTS CITED BY 4843 02:57:20,687 --> 02:57:21,521 WORLD HEALTH ORGANIZATION. 4844 02:57:21,521 --> 02:57:23,590 AND THIS PAPER THAT I THINK I 4845 02:57:23,590 --> 02:57:27,427 PRESENTED LAST YEAR ON 4846 02:57:27,427 --> 02:57:28,395 MACROECONOMIC FACTORS THAT 4847 02:57:28,395 --> 02:57:29,596 INFLUENCE ASSOCIATION BETWEEN 4848 02:57:29,596 --> 02:57:31,598 INCOME AND BRAIN STRUCTURE, AND 4849 02:57:31,598 --> 02:57:35,969 IT WAS ALSO CITED BY THE URBAN 4850 02:57:35,969 --> 02:57:36,403 INSTITUTE. 4851 02:57:36,403 --> 02:57:37,938 JUST DEMONSTRATING THAT WE ARE 4852 02:57:37,938 --> 02:57:39,372 ACHIEVING THE GOALS WE SET OUT 4853 02:57:39,372 --> 02:57:41,975 FOR, TO DO GREAT SCIENCE BUT 4854 02:57:41,975 --> 02:57:42,976 ALSO HAVE THAT SCIENCE USED. 4855 02:57:42,976 --> 02:57:45,111 AND WITH THAT I WOULD LIKE TO 4856 02:57:45,111 --> 02:57:47,681 THANK -- THIS IS AN ENORMOUS 4857 02:57:47,681 --> 02:57:49,549 EFFORT WITH HUNDREDS OF PEOPLE 4858 02:57:49,549 --> 02:57:51,151 WHO ARE INVOLVED IN COLLECTING 4859 02:57:51,151 --> 02:57:53,119 THE DATA AND INTERACTING WITH 4860 02:57:53,119 --> 02:57:54,120 PARTICIPANTS AND THE RESEARCH 4861 02:57:54,120 --> 02:57:56,022 STAFF WHO HAVE DONE AN AMAZING 4862 02:57:56,022 --> 02:57:59,259 JOB GETTING US THROUGH THE COVID 4863 02:57:59,259 --> 02:58:01,161 PANDEMIC AND KEEPING THE 4864 02:58:01,161 --> 02:58:01,895 EXPERIENCE ONE THAT PARTICIPANTS 4865 02:58:01,895 --> 02:58:03,597 WANT TO COME BACK FOR AND OF 4866 02:58:03,597 --> 02:58:04,864 COURSE THE 12,000 PARTICIPANTS 4867 02:58:04,864 --> 02:58:06,833 AND FAMILIES WHO HAVE GIVEN AN 4868 02:58:06,833 --> 02:58:08,168 INORDINATE AMOUNT OF TIME TO THE 4869 02:58:08,168 --> 02:58:11,004 STUDY TO MAKE IT A SUCCESS. 4870 02:58:11,004 --> 02:58:12,339 WITH THAT, WE'RE HAPPY TO TAKE 4871 02:58:12,339 --> 02:58:22,549 QUESTIONS. 4872 02:58:23,316 --> 02:58:27,554 4873 02:58:27,554 --> 02:58:30,290 4874 02:58:30,290 --> 02:58:31,091 >> THAT WAS GREAT PRESENTATION, 4875 02:58:31,091 --> 02:58:33,693 HOW MUCH THIS GENERATED. 4876 02:58:33,693 --> 02:58:35,261 YOU MENTIONED CONCEPTS YOU 4877 02:58:35,261 --> 02:58:36,429 HADN'T YET THOUGHT ABOUT. 4878 02:58:36,429 --> 02:58:37,831 AND I WAS LOOKING THROUGH THE 4879 02:58:37,831 --> 02:58:39,933 DATA DICTIONARY AND I SEE 4880 02:58:39,933 --> 02:58:42,869 THERE'S APPROPRIATELY A LOT ON 4881 02:58:42,869 --> 02:58:43,637 SOCIAL MEDIA USE. 4882 02:58:43,637 --> 02:58:46,606 BUT I COULDN'T FIND IF THERE WAS 4883 02:58:46,606 --> 02:58:48,575 INVERSE OF THAT, WHICH MIGHT NOT 4884 02:58:48,575 --> 02:58:51,077 ADD UP, BECAUSE PEOPLE ARE GOOD 4885 02:58:51,077 --> 02:58:52,278 AT ESTIMATING THESE THINGS, 4886 02:58:52,278 --> 02:58:55,015 WHAT'S THE PERCENTAGE OF TIME 4887 02:58:55,015 --> 02:58:57,517 THAT KIDS ARE ABLE TO SPEND IN 4888 02:58:57,517 --> 02:58:59,052 FACE-TO-FACE CONTACT WITH THEIR 4889 02:58:59,052 --> 02:59:01,321 PEERS BECAUSE I THINK THAT IS 4890 02:59:01,321 --> 02:59:03,556 SORT OF EMERGING AS DRIVING A 4891 02:59:03,556 --> 02:59:05,859 LOT OF ISOLATION AND DEPRESSION 4892 02:59:05,859 --> 02:59:07,594 AND ANXIETY, ESPECIALLY AMONG 4893 02:59:07,594 --> 02:59:07,994 GIRLS. 4894 02:59:07,994 --> 02:59:10,096 >> YEAH, IT'S A REALLY GOOD 4895 02:59:10,096 --> 02:59:10,363 QUESTION. 4896 02:59:10,363 --> 02:59:11,297 WE HAVE INFORMATION ABOUT WHAT 4897 02:59:11,297 --> 02:59:12,732 THEY ARE DOING BUT I DON'T THINK 4898 02:59:12,732 --> 02:59:13,700 WE HAVE THAT MUCH INFORMATION 4899 02:59:13,700 --> 02:59:15,502 ABOUT HOW MUCH TIME THEY ARE 4900 02:59:15,502 --> 02:59:16,569 SPENDING IN THOSE DIFFERENT 4901 02:59:16,569 --> 02:59:17,103 ACTIVITIES. 4902 02:59:17,103 --> 02:59:20,073 SO WE DO COLLECT INFORMATION 4903 02:59:20,073 --> 02:59:23,009 ABOUT PLACES THEY SPEND TIME, AS 4904 02:59:23,009 --> 02:59:24,344 WELL AS DIFFERENT ACTIVITIES 4905 02:59:24,344 --> 02:59:25,645 THAT THEY PARTICIPATE IN, SPORTS 4906 02:59:25,645 --> 02:59:27,614 ACTIVITIES, AND THERE WE DO GET 4907 02:59:27,614 --> 02:59:29,916 INFORMATION IN TERMS OF, YOU 4908 02:59:29,916 --> 02:59:31,451 KNOW, HOW OFTEN, IF THEY ARE 4909 02:59:31,451 --> 02:59:34,421 PART OF A CLUB OR INDEPENDENTLY, 4910 02:59:34,421 --> 02:59:36,589 HOW MUCH TIME PER WEEK, SO WE 4911 02:59:36,589 --> 02:59:38,858 COULD LOOK AT THAT OVER TIME TO 4912 02:59:38,858 --> 02:59:40,026 SEE IF THERE ARE CHANGES. 4913 02:59:40,026 --> 02:59:42,929 AND WE COULD ALSO LOOK TO SEE 4914 02:59:42,929 --> 02:59:43,563 WHAT THAT RELATIONSHIP BETWEEN 4915 02:59:43,563 --> 02:59:44,798 THE AMOUNT OF TIME THEY ARE 4916 02:59:44,798 --> 02:59:46,533 SPENDING IN THOSE ACTIVITIES 4917 02:59:46,533 --> 02:59:47,734 VERSUS AMOUNT OF TIME THEY ARE 4918 02:59:47,734 --> 02:59:48,935 SPENDING ON SCREENS AND WHETHER 4919 02:59:48,935 --> 02:59:49,936 THERE'S A RELATIONSHIP THERE AS 4920 02:59:49,936 --> 02:59:50,170 WELL. 4921 02:59:50,170 --> 02:59:52,439 BUT ONE OF THE THINGS THAT AS 4922 02:59:52,439 --> 02:59:53,773 WE'RE STARTING TO THINK ABOUT 4923 02:59:53,773 --> 02:59:57,043 THE NEXT PHASE OF ABCD, I THINK 4924 02:59:57,043 --> 02:59:58,678 THE SOCIAL INTERACTION PIECE IS 4925 02:59:58,678 --> 03:00:01,081 GOING TO BE AT THE CENTER OF 4926 03:00:01,081 --> 03:00:01,848 EVERYTHING THAT WE DO. 4927 03:00:01,848 --> 03:00:06,219 I THINK IT'S ONE THAT WE 4928 03:00:06,219 --> 03:00:07,020 HAVE SOME INFORMATION BUT SO 4929 03:00:07,020 --> 03:00:08,521 MUCH MORE PARTICULARLY AS THEY 4930 03:00:08,521 --> 03:00:10,490 START TO AGE OUT OF HIGH SCHOOL 4931 03:00:10,490 --> 03:00:12,726 AND GO ON TO DIFFERENT PATHS, 4932 03:00:12,726 --> 03:00:13,493 UNDERSTANDING THEIR SOCIAL 4933 03:00:13,493 --> 03:00:16,996 ENVIRONMENTS IS GOING TO BE 4934 03:00:16,996 --> 03:00:24,971 REALLY IMPORTANT. 4935 03:00:24,971 --> 03:00:25,739 >> THANK YOU. 4936 03:00:25,739 --> 03:00:28,274 YOU'RE DOING SO MUCH, SO WELL, I 4937 03:00:28,274 --> 03:00:30,877 WOULD DARE SUGGEST CAN WE DO 4938 03:00:30,877 --> 03:00:31,811 EVEN MORE. 4939 03:00:31,811 --> 03:00:33,947 SO, WHAT I KEEP THINKING, RIGHT, 4940 03:00:33,947 --> 03:00:35,815 SO THE ABCD KIDS ARE NOT GOING 4941 03:00:35,815 --> 03:00:40,420 TO BE KIDS ANYMORE VERY SOON. 4942 03:00:40,420 --> 03:00:43,823 AND IN THE ABCD WE HAVE THIS 4943 03:00:43,823 --> 03:00:44,924 AMAZING OPPORTUNITY OF LOOKING 4944 03:00:44,924 --> 03:00:48,862 AT WHAT HAPPENS IN PREGNANCY, 4945 03:00:48,862 --> 03:00:49,429 UNDERSTANDING VULNERABILITY 4946 03:00:49,429 --> 03:00:51,831 EARLIER BUT CAN WE UNDERSTAND IT 4947 03:00:51,831 --> 03:00:54,667 EVEN EARLIER? 4948 03:00:54,667 --> 03:00:56,970 AND START THINKING ABOUT 4949 03:00:56,970 --> 03:00:58,404 INFLUENCES THAT ARE 4950 03:00:58,404 --> 03:01:01,541 INTERGENERATIONAL BY BEING ABLE 4951 03:01:01,541 --> 03:01:03,877 TO RECRUIT THE KIDS OF ABCD, NEW 4952 03:01:03,877 --> 03:01:05,445 PREGNANCIES THAT ARE GOING TO 4953 03:01:05,445 --> 03:01:07,714 START HAPPENING, IN THE NEXT TEN 4954 03:01:07,714 --> 03:01:09,349 YEARS OR SO, AND SHARING QUICKLY 4955 03:01:09,349 --> 03:01:11,985 THE EXPERIENCE THAT WE HAVE 4956 03:01:11,985 --> 03:01:15,688 DOING THAT AS PART OF STUDY OF 4957 03:01:15,688 --> 03:01:19,325 2500 PUERTO RICAN CHILDREN IN 4958 03:01:19,325 --> 03:01:21,528 WHICH WE -- DURING YOUNG 4959 03:01:21,528 --> 03:01:23,263 ADULTHOOD HAD CONVERSATIONS WITH 4960 03:01:23,263 --> 03:01:26,032 OUR KIDS ABOUT SEXUAL RISK 4961 03:01:26,032 --> 03:01:27,667 BEHAVIORS. 4962 03:01:27,667 --> 03:01:29,068 AND THAT ACTUALLY FACILITATED TO 4963 03:01:29,068 --> 03:01:30,970 TALK ABOUT PREGNANCY AND SCREEN 4964 03:01:30,970 --> 03:01:31,905 PREGNANCY REGULARLY WHICH IS 4965 03:01:31,905 --> 03:01:33,673 WHAT YOU NEED TO DO IN ORDER TO 4966 03:01:33,673 --> 03:01:36,309 BE ABLE TO BUILD AN 4967 03:01:36,309 --> 03:01:37,410 INTERGENERATIONAL COHORT. 4968 03:01:37,410 --> 03:01:40,113 SO JUST, YOU KNOW, PLANTING THE 4969 03:01:40,113 --> 03:01:41,781 SEED BECAUSE WE DON'T HAVE A LOT 4970 03:01:41,781 --> 03:01:42,448 OF TIME. 4971 03:01:42,448 --> 03:01:43,750 PREGNANCIES ARE GOING TO START 4972 03:01:43,750 --> 03:01:45,952 VERY, VERY SOON IN THE ABCD. 4973 03:01:45,952 --> 03:01:47,687 I SAID THAT IN OTHER FORUMS BUT 4974 03:01:47,687 --> 03:01:49,656 I'LL SAY IT HERE AS WELL. 4975 03:01:49,656 --> 03:01:51,524 >> YEAH, WE'VE HAD A COUPLE 4976 03:01:51,524 --> 03:01:54,127 PREGNANCIES IN THE COHORT 4977 03:01:54,127 --> 03:01:54,360 ALREADY. 4978 03:01:54,360 --> 03:01:56,396 BUT IT'S A GREAT POINT, IT'S ONE 4979 03:01:56,396 --> 03:01:57,897 WE'RE TALKING ABOUT AT LUNCH 4980 03:01:57,897 --> 03:01:58,665 YESTERDAY AS WELL THAT, YOU 4981 03:01:58,665 --> 03:02:01,067 KNOW, WE HAVE A UNIQUE ABILITY 4982 03:02:01,067 --> 03:02:03,169 IF WE CONTINUE TO FOLLOW THEM 4983 03:02:03,169 --> 03:02:04,671 THROUGH THESE NEXT TEN YEARS OR 4984 03:02:04,671 --> 03:02:07,607 MORE TO BE ABLE TO LOOK AT THAT 4985 03:02:07,607 --> 03:02:08,208 INTERGENERATIONAL BECAUSE WE 4986 03:02:08,208 --> 03:02:09,475 HAVE SO MUCH INFORMATION ABOUT 4987 03:02:09,475 --> 03:02:14,848 THEIR YOUTH TO SEE WHAT IS 4988 03:02:14,848 --> 03:02:15,481 INFLUENCING THOSE TRAJECTORIES. 4989 03:02:15,481 --> 03:02:17,150 I DON'T KNOW IF WE'LL BE ABLE TO 4990 03:02:17,150 --> 03:02:18,451 DO THAT, THAT'S MORE OF A 4991 03:02:18,451 --> 03:02:19,919 QUESTION FOR NORA AND GEORGE, 4992 03:02:19,919 --> 03:02:21,321 SOMETHING WE WANT TO DO. 4993 03:02:21,321 --> 03:02:22,956 THE OTHER POSSIBILITY IS THAT WE 4994 03:02:22,956 --> 03:02:25,692 DO HAVE SOME OF OUR SITES 4995 03:02:25,692 --> 03:02:26,893 CO-LOCATED WITH HBCD SO IF 4996 03:02:26,893 --> 03:02:33,266 THERE'S A WAY WE CAN ENROLL 4997 03:02:33,266 --> 03:02:35,335 PEOPLE IN HBCD, PULL THAT DATA 4998 03:02:35,335 --> 03:02:36,970 SHARED THROUGH THE SAME 4999 03:02:36,970 --> 03:02:37,470 PLATFORM. 5000 03:02:37,470 --> 03:02:38,404 >> I THINK THAT THE NATURAL 5001 03:02:38,404 --> 03:02:42,809 ANSWER IS OF COURSE WE WANT IT, 5002 03:02:42,809 --> 03:02:43,776 SCIENTIFICALLY IT MAKES SENSE. 5003 03:02:43,776 --> 03:02:45,211 THE DECISION IS NOT UP TO GEORGE 5004 03:02:45,211 --> 03:02:46,512 AND MYSELF, IT'S WHAT LEVEL OF 5005 03:02:46,512 --> 03:02:48,081 FUNDING WE GET AND THE SUPPORT 5006 03:02:48,081 --> 03:02:49,916 WE HAVE BECAUSE WE HAVE BEEN 5007 03:02:49,916 --> 03:02:56,389 KARAOKE -- CARRYING MOST OF THE 5008 03:02:56,389 --> 03:02:56,623 BUDGET. 5009 03:02:56,623 --> 03:02:57,790 THE MAIN BURDEN HAS COME REALLY 5010 03:02:57,790 --> 03:03:02,295 TO BOTH OF OUR INSTITUTES SO WE 5011 03:03:02,295 --> 03:03:03,930 WOULD ABSOLUTELY -- WE'RE 5012 03:03:03,930 --> 03:03:05,031 COMMITTED TO THE STUDY AND WANT 5013 03:03:05,031 --> 03:03:06,432 IT TO BE SUCCESSFUL AND BE ABLE 5014 03:03:06,432 --> 03:03:08,334 TO DO MORE BUT WITHOUT 5015 03:03:08,334 --> 03:03:10,503 RESOURCES, SO I THINK I'M 5016 03:03:10,503 --> 03:03:11,537 BRINGING IT UP, QUITE OBVIOUS 5017 03:03:11,537 --> 03:03:15,775 BOUGH I THINK OF -- BECAUSE ALL 5018 03:03:15,775 --> 03:03:18,177 OF YOU CAN COMMUNICATE THE VALUE 5019 03:03:18,177 --> 03:03:19,279 OF THE STUDY SO THERE'S 5020 03:03:19,279 --> 03:03:21,915 RECOGNITION AND SUPPORT TO KEEP 5021 03:03:21,915 --> 03:03:23,850 IT GOING BECAUSE IT WOULD BE A 5022 03:03:23,850 --> 03:03:26,252 BIG, BIG LOSS IF WE COULD NOT 5023 03:03:26,252 --> 03:03:28,354 FOLLOW THESE CHILDREN, WELL, 5024 03:03:28,354 --> 03:03:29,689 THESE TEENAGERS, INTO ADULTHOOD. 5025 03:03:29,689 --> 03:03:31,324 YES, THAT'S THE INTENT AND I 5026 03:03:31,324 --> 03:03:41,834 HOPE THAT MONEY ARRIVES TO OUR 5027 03:03:43,303 --> 03:03:43,903 INSTITUTES. 5028 03:03:43,903 --> 03:03:44,437 >> THANK YOU. 5029 03:03:44,437 --> 03:03:45,872 >> YEAH, THANKS VERY MUCH, AS 5030 03:03:45,872 --> 03:03:47,440 ALWAYS. 5031 03:03:47,440 --> 03:03:48,308 AND THE NEXT PRESENTATION IS 5032 03:03:48,308 --> 03:03:51,644 GOING TO BE GIVEN BY DR. MICAH 5033 03:03:51,644 --> 03:04:00,286 JOHNSON ON THE START PROGRAM, 5034 03:04:00,286 --> 03:04:04,457 AND HE'S A SOCIOLOGIST, RESEARCH 5035 03:04:04,457 --> 03:04:08,294 INVESTIGATES SYNERGISTIC EFFECTS 5036 03:04:08,294 --> 03:04:10,797 OF PSYCHOLOGICAL TRAUMA, SOCIAL 5037 03:04:10,797 --> 03:04:11,464 DETERMINANTS, SUBSTANCE MISUSE 5038 03:04:11,464 --> 03:04:15,535 AND SERVICES FOR THE PEDIATRIC 5039 03:04:15,535 --> 03:04:17,503 POPULATIONS, WORKS ON DEATH ROW 5040 03:04:17,503 --> 03:04:19,472 TO UNDERSTAND RELATIONSHIP 5041 03:04:19,472 --> 03:04:22,976 BETWEEN TRAUMA, SUBSTANCE USE, 5042 03:04:22,976 --> 03:04:23,309 INCARCERATION. 5043 03:04:23,309 --> 03:04:25,712 DR. JOHNSON LEADS TWO 5044 03:04:25,712 --> 03:04:28,114 COMPREHENSIVE INITIATIVE THAT 5045 03:04:28,114 --> 03:04:33,820 RECRUITS, TRAINS, CULTIVATES 5046 03:04:33,820 --> 03:04:34,787 UNDERREPRESENTED MINORITY AND 5047 03:04:34,787 --> 03:04:36,889 DISADVANTAGED, TO BECOME THE 5048 03:04:36,889 --> 03:04:39,192 NEXT GENERATION OF SUBSTANCE 5049 03:04:39,192 --> 03:04:41,260 MISUSE AND ADDICTIVE SCIENTISTS, 5050 03:04:41,260 --> 03:04:43,997 HIS WORK CITED BY THE "NEW YORK 5051 03:04:43,997 --> 03:04:48,601 TIMES," ESPN, SENATOR BERNIE 5052 03:04:48,601 --> 03:04:51,871 SANDERS, AND OTHERS, RECIPIENT 5053 03:04:51,871 --> 03:04:55,141 OF 2023 OUTSTANDING RESEARCH 5054 03:04:55,141 --> 03:04:58,778 AWARD FROM UNIVERSITY OF SOUTH 5055 03:04:58,778 --> 03:05:00,513 FLORIDA, 2023 COMMUNITY RIVER 5056 03:05:00,513 --> 03:05:02,181 PHOENIX CENTER, AND 2024 5057 03:05:02,181 --> 03:05:04,384 OUTSTANDING MENTOR AWARD FROM 5058 03:05:04,384 --> 03:05:12,792 THE FLORIDA EDUCATION FUND. 5059 03:05:12,792 --> 03:05:13,559 DR. JOHNSON, WELCOME. 5060 03:05:13,559 --> 03:05:15,728 >> THANK YOU. 5061 03:05:15,728 --> 03:05:18,664 I'M PRE-SENTING ON MYSELF AND I 5062 03:05:18,664 --> 03:05:24,370 COULD ON CO-P.I.S, DR. POTTER 5063 03:05:24,370 --> 03:05:30,510 AND GARRAGAN. 5064 03:05:30,510 --> 03:05:31,144 I'LL DESCRIBE START, THE 5065 03:05:31,144 --> 03:05:32,779 INITIATIVE WAS DESIGNED TO BE A 5066 03:05:32,779 --> 03:05:37,183 MODEL THAT CAN BE REPLICATED AND 5067 03:05:37,183 --> 03:05:40,486 ADOPTED FOR VARIOUS OTHER 5068 03:05:40,486 --> 03:05:41,554 CONSORTIA AND RESEARCH 5069 03:05:41,554 --> 03:05:42,088 COMMUNITIES. 5070 03:05:42,088 --> 03:05:44,090 I'LL START BY SAYING THAT THE 5071 03:05:44,090 --> 03:05:44,991 START PROGRAM SUPPORTED BY NIDA 5072 03:05:44,991 --> 03:05:47,393 AND THIS PROGRAM WOULD NOT BE 5073 03:05:47,393 --> 03:05:56,069 POSSIBLE WITHOUT THE NIDA 5074 03:05:56,069 --> 03:06:06,612 COUNCIL, NIDA PROGRAM OFFICERS. 5075 03:06:09,882 --> 03:06:12,552 CERTAIN GROUPS HAVE FEWER 5076 03:06:12,552 --> 03:06:14,053 RESOURCES DUE TO HISTORICAL 5077 03:06:14,053 --> 03:06:16,956 FACTORS, MANY FOLKS FACE 5078 03:06:16,956 --> 03:06:19,258 BARRIERS, POTHOLES, ON ACADEMIC 5079 03:06:19,258 --> 03:06:24,163 JOURNEYS, THAT DETER THEM FROM 5080 03:06:24,163 --> 03:06:25,898 PURSUING RESEARCH CAREERS. 5081 03:06:25,898 --> 03:06:27,667 NOT SURPRISINGLY CERTAIN GROUPS 5082 03:06:27,667 --> 03:06:29,969 ARE GROSSLY UNDERREPRESENTED IN 5083 03:06:29,969 --> 03:06:31,504 ACADEMIA ESPECIALLY AMONG VERY 5084 03:06:31,504 --> 03:06:32,238 PRESTIGIOUS RESEARCH 5085 03:06:32,238 --> 03:06:32,839 COMMUNITIES. 5086 03:06:32,839 --> 03:06:43,282 THIS TYPE OF CULTURAL AND 5087 03:06:45,451 --> 03:06:46,285 ETHNIC -- RESEARCH TRAINING 5088 03:06:46,285 --> 03:06:51,624 PROGRAMS ARE ESSENTIAL TO 5089 03:06:51,624 --> 03:06:52,725 ADDRESS THESE ISSUES. 5090 03:06:52,725 --> 03:06:58,764 HUGH AND ALEXEI ARE THE 5091 03:06:58,764 --> 03:07:00,833 CO-P.I.s AT THE UNIVERSITY OF 5092 03:07:00,833 --> 03:07:06,105 VERMONT, PARTNERED WITH ME, IN 5093 03:07:06,105 --> 03:07:07,974 DESIGNING RESEARCH EDUCATION 5094 03:07:07,974 --> 03:07:08,808 PROGRAMS FOR DIVERSE 5095 03:07:08,808 --> 03:07:10,409 POPULATIONS, AND I HAVE A LONG 5096 03:07:10,409 --> 03:07:20,853 HISTORY WITH PEDAGOGY AND 5097 03:07:21,354 --> 03:07:22,188 CURRICULUM DESIGNED. 5098 03:07:22,188 --> 03:07:23,456 WE LAUNCHED A FULL PROGRAM, THE 5099 03:07:23,456 --> 03:07:26,325 GOAL OF THE START PROGRAM TO 5100 03:07:26,325 --> 03:07:28,628 RECRUIT, TRAIN, MENTOR GIFTED 5101 03:07:28,628 --> 03:07:31,264 JUNIOR SCHOLARS, FOLKS WITH 5102 03:07:31,264 --> 03:07:33,332 DIVERSE PERSPECTIVE AND 5103 03:07:33,332 --> 03:07:34,333 BACKGROUNDS TO ACCESS, ANALYZE, 5104 03:07:34,333 --> 03:07:40,773 DISSEMINATE DATA FROM ABC D 5105 03:07:40,773 --> 03:07:40,973 STUDY. 5106 03:07:40,973 --> 03:07:44,877 START EMBRACES FIVE PILLARS, 5107 03:07:44,877 --> 03:07:50,082 RECRUITMENT OF FOLKS WHO FIT THE 5108 03:07:50,082 --> 03:07:51,817 NIH CRITERIA FOR 5109 03:07:51,817 --> 03:07:52,518 UNDERREPRESENTATION, GIFTED, MAY 5110 03:07:52,518 --> 03:07:55,254 NEED A PUSH OR LACK FOR 5111 03:07:55,254 --> 03:08:01,827 RESOURCES, WE BELIEVE IN EARLY 5112 03:08:01,827 --> 03:08:02,995 CAREER ENRICHMENT AND NOURISHING 5113 03:08:02,995 --> 03:08:03,362 ENVIRONMENT. 5114 03:08:03,362 --> 03:08:05,231 THE PROGRAM WAS DESIGNED TO 5115 03:08:05,231 --> 03:08:08,167 ADDRESS NIDA'S KEY AREAS, 5116 03:08:08,167 --> 03:08:09,368 EXPANDING WORKFORCE PREPARATION, 5117 03:08:09,368 --> 03:08:11,671 TO MEET NATIONAL AND GLOBAL 5118 03:08:11,671 --> 03:08:12,572 NEEDS, ENCOURAGE 5119 03:08:12,572 --> 03:08:14,106 UNDERREPRESENTED GROUPS TO 5120 03:08:14,106 --> 03:08:15,741 PURSUE CAREERS IN RESEARCH, 5121 03:08:15,741 --> 03:08:18,244 ADVANCE SCIENCE ON CONSEQUENCE 5122 03:08:18,244 --> 03:08:20,446 AND TREATMENT OF SUBSTANCE 5123 03:08:20,446 --> 03:08:25,685 ISSUES, BUT ALSO ENHANCE 5124 03:08:25,685 --> 03:08:27,320 RESEARCH ON UNDERREPRESENTED 5125 03:08:27,320 --> 03:08:28,421 POPULATIONS. 5126 03:08:28,421 --> 03:08:31,257 SO WE START WITH RECRUITMENT. 5127 03:08:31,257 --> 03:08:39,899 WE EXECUTED A TARGETED STRATEGY 5128 03:08:39,899 --> 03:08:40,900 LEVERAGE PROFESSIONAL TECHNIQUES 5129 03:08:40,900 --> 03:08:43,236 FROM FORTUNE 500 COMPANIES, 5130 03:08:43,236 --> 03:08:45,471 SOCIAL CAPITAL IN COLLABORATION 5131 03:08:45,471 --> 03:08:46,272 WITH ORGANIZATIONS THAT SERVE 5132 03:08:46,272 --> 03:08:47,673 DIVERSE COMMUNITIES. 5133 03:08:47,673 --> 03:08:49,442 WE RECEIVED WELL OVER HUNDREDS 5134 03:08:49,442 --> 03:08:52,044 OF APPLICATIONS INDICATING THERE 5135 03:08:52,044 --> 03:08:54,647 WAS INTEREST, AND NEED IN THESE 5136 03:08:54,647 --> 03:08:56,148 SORTS OF OPPORTUNITIES. 5137 03:08:56,148 --> 03:08:58,284 WE'RE WORKING WITH -- WE PLAN 5138 03:08:58,284 --> 03:09:00,620 WITH WORK WITH R25S AND PROGRAMS 5139 03:09:00,620 --> 03:09:02,688 TO EXPAND TO MEET THAT NEED. 5140 03:09:02,688 --> 03:09:06,959 I'LL TELL YOU ABOUT THE PILOT 5141 03:09:06,959 --> 03:09:09,996 COHORT. 5142 03:09:09,996 --> 03:09:12,798 FOUR PRE-DOCS, FOUR POSTDOCS, 5143 03:09:12,798 --> 03:09:14,533 FOUR EARLY CAREER MEMBERS, 5144 03:09:14,533 --> 03:09:16,802 STAGGERED ENROLLMENT APPROACH SO 5145 03:09:16,802 --> 03:09:23,242 WE COULD FACILITATE PEER MENTOR 5146 03:09:23,242 --> 03:09:27,413 SHIP, REFLECTING A DOZEN 5147 03:09:27,413 --> 03:09:30,049 DISCIPLINES, TEN UNIVERSITIES, 5148 03:09:30,049 --> 03:09:32,451 SIX COUNTRIES OF ORIGIN, 5149 03:09:32,451 --> 03:09:34,086 ACCOMPLISHED OVER 160 5150 03:09:34,086 --> 03:09:36,689 PUBLICATIONS, NOW CLOSE TO 200, 5151 03:09:36,689 --> 03:09:39,225 HIGH-IMPACT JOURNALS, OVER 200 5152 03:09:39,225 --> 03:09:41,327 PRESENTATIONS AT SCIENTIFIC 5153 03:09:41,327 --> 03:09:42,862 MEETINGS, 12 ORIGINAL ABCD 5154 03:09:42,862 --> 03:09:46,365 PROJECTS RELATED TO SUBSTANCE 5155 03:09:46,365 --> 03:09:47,667 ISSUES, ALSO NOW UP TO 15. 5156 03:09:47,667 --> 03:09:51,470 30% OF THE PILOT COHORT HAVE 5157 03:09:51,470 --> 03:09:56,409 PUBLISHED THEIR RESEARCH IN 5158 03:09:56,409 --> 03:09:56,976 PEER-REVIEWED JOURNALS, 5159 03:09:56,976 --> 03:09:59,378 ACCOLADES INCLUDE K01 AND AWARDS 5160 03:09:59,378 --> 03:10:00,446 AND PROMOTIONS AND 5161 03:10:00,446 --> 03:10:01,047 ACKNOWLEDGMENT MILESTONES AND 5162 03:10:01,047 --> 03:10:01,280 HONORS. 5163 03:10:01,280 --> 03:10:06,852 ONE OF THE MEMBERS WON THE ABCD 5164 03:10:06,852 --> 03:10:08,020 INVESTIGATOR OF THE YEAR. 5165 03:10:08,020 --> 03:10:09,989 SO IN A SHORT AMOUNT OF TIME 5166 03:10:09,989 --> 03:10:12,725 WE'VE ALREADY TRAINED 24 5167 03:10:12,725 --> 03:10:14,593 SCHOLARS, MANY WOULD NOT ONLY 5168 03:10:14,593 --> 03:10:16,896 CONTINUE TO CONTRIBUTE TO THE 5169 03:10:16,896 --> 03:10:19,332 ABCD CONSORTIUM BUT BE FUTURE 5170 03:10:19,332 --> 03:10:21,400 LEADERS IN THEIR FIELDS. 5171 03:10:21,400 --> 03:10:24,537 THIS IMAGE DEMONSTRATES THE 5172 03:10:24,537 --> 03:10:25,338 POTENTIAL TO DRAMATICALLY 5173 03:10:25,338 --> 03:10:26,539 ENHANCE REPRESENTATIVE OF JUNIOR 5174 03:10:26,539 --> 03:10:29,575 SCHOLARS FROM ARRAY OF 5175 03:10:29,575 --> 03:10:31,277 BACKGROUNDS ESPECIALLY 5176 03:10:31,277 --> 03:10:35,715 HISTORICAL UNDERREPRESENTED, WHO 5177 03:10:35,715 --> 03:10:36,415 ARE HISTORICALLY 5178 03:10:36,415 --> 03:10:37,316 UNDERREPRESENTED IN FIELDS. 5179 03:10:37,316 --> 03:10:38,918 THIS IS THE PILOT AND FIRST 5180 03:10:38,918 --> 03:10:39,285 COHORT. 5181 03:10:39,285 --> 03:10:41,487 BY THE END WE WOULD HAVE TRAINED 5182 03:10:41,487 --> 03:10:45,624 AND MENTORED 60 SCHOLARS IN FOUR 5183 03:10:45,624 --> 03:10:47,226 YEARS. 5184 03:10:47,226 --> 03:10:51,564 SO START ENHANCES DIVERSITY AND 5185 03:10:51,564 --> 03:10:55,134 SERVES TO ENHANCE DIVERSITY IN 5186 03:10:55,134 --> 03:10:57,570 ADVANCED SCIENCE, BIOMEDICAL 5187 03:10:57,570 --> 03:11:00,539 SCIENCES MORE BROADLY. 5188 03:11:00,539 --> 03:11:02,274 THE START PROGRAM HAS THREE 5189 03:11:02,274 --> 03:11:02,508 PHASES. 5190 03:11:02,508 --> 03:11:04,009 I'LL GO THROUGH EACH. 5191 03:11:04,009 --> 03:11:06,545 PHASE 1 IS A ONE-WEEK INTENSIVE 5192 03:11:06,545 --> 03:11:07,413 ORIENTATION AND TRAINING 5193 03:11:07,413 --> 03:11:09,949 CONFERENCE AT UNIVERSITY OF 5194 03:11:09,949 --> 03:11:10,616 VERMONT. 5195 03:11:10,616 --> 03:11:12,918 PHASE 2 IS VIRTUAL, MONTHLY 5196 03:11:12,918 --> 03:11:14,487 TWO-HOUR GROUP SESSIONS. 5197 03:11:14,487 --> 03:11:19,225 PHASE 3 IS A THREE TO FOUR-DAY 5198 03:11:19,225 --> 03:11:21,327 DISSEMINATION CONFERENCE ON 5199 03:11:21,327 --> 03:11:22,294 PUBLICATIONS, PRESENTATIONS, 5200 03:11:22,294 --> 03:11:23,629 PROFESSIONAL DEVELOPMENT, ALSO 5201 03:11:23,629 --> 03:11:25,698 GRANTSMANSHIP AND OTHER ASPECTS 5202 03:11:25,698 --> 03:11:30,202 OF PROFESSIONAL DEVELOPMENT. 5203 03:11:30,202 --> 03:11:34,440 SO WE FLY TRAINEES TO THE SITE 5204 03:11:34,440 --> 03:11:38,377 AT UVM, FOR ONE WEEK INTENSIVE 5205 03:11:38,377 --> 03:11:39,145 ORGANIZATION, RECEIVING 5206 03:11:39,145 --> 03:11:41,247 INSTRUCTION IN HISTORY, 5207 03:11:41,247 --> 03:11:42,648 RECRUITMENT, PROCEDURES, DAILY 5208 03:11:42,648 --> 03:11:43,416 COLLECTION PROCESSES, 5209 03:11:43,416 --> 03:11:45,384 PARTICIPATE IN DATA COLLECTION 5210 03:11:45,384 --> 03:11:47,686 DEMONSTRATIONS AND TOUR DATA 5211 03:11:47,686 --> 03:11:48,788 COLLECTION FACILITIES, RECEIVE 5212 03:11:48,788 --> 03:11:51,190 INSTRUCTION ON ALL ASPECTS OF 5213 03:11:51,190 --> 03:11:54,026 THE STUDY, WHAT'S POSSIBLE, WE 5214 03:11:54,026 --> 03:11:54,927 GIVE THEM IDEAS, SHOW 5215 03:11:54,927 --> 03:11:56,095 DEMONSTRATIONS AND ASK THEM WHAT 5216 03:11:56,095 --> 03:12:03,702 IS POSSIBLE FOR IDEAS AS WELL. 5217 03:12:03,702 --> 03:12:07,306 THEY PARTICIPATE AND WE MOVE 5218 03:12:07,306 --> 03:12:07,640 FORWARD. 5219 03:12:07,640 --> 03:12:11,977 EVERYTHING IS ACTUAL PICTURES OF 5220 03:12:11,977 --> 03:12:16,182 THE START PILOT PROGRAM 5221 03:12:16,182 --> 03:12:18,017 INAUGURAL COHORT. 5222 03:12:18,017 --> 03:12:19,218 WE VALIDATE TRAINEES EXPERIENCES 5223 03:12:19,218 --> 03:12:20,719 IN EMPOWERING THEM TO BE PART OF 5224 03:12:20,719 --> 03:12:22,621 THE SOLUTION, ONE OF THE FIRST 5225 03:12:22,621 --> 03:12:23,956 ACTIVITIES IS A POWERFUL 5226 03:12:23,956 --> 03:12:25,991 DISCUSSION ABOUT THE CHALLENGES 5227 03:12:25,991 --> 03:12:30,162 THESE SCHOLARS MAY FACE, AND A 5228 03:12:30,162 --> 03:12:31,263 DISCUSSION OF PERSONAL AND 5229 03:12:31,263 --> 03:12:33,332 SOCIAL SOLUTIONS TO HELP THEM 5230 03:12:33,332 --> 03:12:36,402 OVERCOME AND THRIVE. 5231 03:12:36,402 --> 03:12:37,636 WE VALIDATE EXPERIENCES, EMPOWER 5232 03:12:37,636 --> 03:12:39,505 THEM WITH TOOLS AND RESOURCES 5233 03:12:39,505 --> 03:12:41,240 AND ALSO BRAINSTORM WAYS WE CAN 5234 03:12:41,240 --> 03:12:43,876 ADDRESS THESE ISSUES MORE 5235 03:12:43,876 --> 03:12:46,846 STRUCTURALLY AND SOCIALLY. 5236 03:12:46,846 --> 03:12:48,147 NEXT WE FACILITATE MENTOR-MENTEE 5237 03:12:48,147 --> 03:12:49,915 COLLABORATION TO DEVELOP 5238 03:12:49,915 --> 03:12:50,649 RESEARCH STUDIES LEVERAGING 5239 03:12:50,649 --> 03:12:50,916 DATASETS. 5240 03:12:50,916 --> 03:12:52,651 THIS IS ONE OF THE RESEARCH 5241 03:12:52,651 --> 03:12:54,954 FORUMS WE USE. 5242 03:12:54,954 --> 03:12:58,357 THIS FORUM HERE EVOLVED FROM 5243 03:12:58,357 --> 03:13:01,961 CHICKEN SCRATCH AND DOODLES TO A 5244 03:13:01,961 --> 03:13:04,129 TANGIBLE ANALYTICAL PLAN THAT 5245 03:13:04,129 --> 03:13:08,868 EVENTUALLY TRANSFORMED INTO A 5246 03:13:08,868 --> 03:13:09,401 RESEARCH STUDY. 5247 03:13:09,401 --> 03:13:13,906 THE CORE OF THIS PROGRAM IS 5248 03:13:13,906 --> 03:13:15,241 MENTORSHIP. 5249 03:13:15,241 --> 03:13:18,377 WE EMPLOY MULTI-LEVEL MENTORING 5250 03:13:18,377 --> 03:13:20,112 MODEL INCLUDING ONE-ON-ONE AND 5251 03:13:20,112 --> 03:13:21,747 SMALL GROUP, PEER MENTORING, 5252 03:13:21,747 --> 03:13:24,183 COMMUNITY MENTORING, AND FLIPPED 5253 03:13:24,183 --> 03:13:24,717 MENTORSHIP. 5254 03:13:24,717 --> 03:13:26,585 WE FACILITATE THE PANEL LED BY 5255 03:13:26,585 --> 03:13:28,787 SENIOR SCHOLARS TO DISCUSS 5256 03:13:28,787 --> 03:13:29,989 EFFECTIVE MENTORSHIP PRACTICES, 5257 03:13:29,989 --> 03:13:36,762 AND THEN WE FLIP THE PANEL SO 5258 03:13:36,762 --> 03:13:41,133 TRAINEES LEAD THE DISCUSSION AND 5259 03:13:41,133 --> 03:13:42,601 GIVE US ACTUAL TIPS AND GUIDE US 5260 03:13:42,601 --> 03:13:44,870 ON WHAT WORKS FOR THEM, WHAT 5261 03:13:44,870 --> 03:13:47,506 THINGS HAD WE NOT THOUGHT ABOUT, 5262 03:13:47,506 --> 03:13:49,909 WHAT CAN WE LEARN ABOUT 5263 03:13:49,909 --> 03:13:50,910 MENTORSHIP FROM THEM. 5264 03:13:50,910 --> 03:13:53,312 THIS WAS ALSO A GREAT 5265 03:13:53,312 --> 03:13:55,147 OPPORTUNITY FOR THEM TO EDUCATE 5266 03:13:55,147 --> 03:13:56,715 SENIOR COLLEAGUES AND MENTORS ON 5267 03:13:56,715 --> 03:13:57,683 THEIR UNIQUE EXPERIENCES IN 5268 03:13:57,683 --> 03:14:03,155 ACADEMIA THAT MOST FOLKS MAY NOT 5269 03:14:03,155 --> 03:14:03,923 BE AWARE OF. 5270 03:14:03,923 --> 03:14:05,891 IT'S IMPORTANT TO NOTE FOR TWO 5271 03:14:05,891 --> 03:14:09,228 YEARS WE HAVE HAD A SURPLUS OF 5272 03:14:09,228 --> 03:14:11,931 MENTORSHIP INCLUDING MEMBERS OF 5273 03:14:11,931 --> 03:14:15,568 THE ABCD CONSORTIA AND 5274 03:14:15,568 --> 03:14:18,837 COMMUNITY, THIS YEAR WE'VE HAD 5275 03:14:18,837 --> 03:14:21,340 AN ALL-STAR CAST INCLUDING 5276 03:14:21,340 --> 03:14:24,610 SEVERAL SITE P.I.S AND LEADERS. 5277 03:14:24,610 --> 03:14:26,712 BECAUSE OF THE SUPPORT WE WERE 5278 03:14:26,712 --> 03:14:29,882 ABLE TO PAIR MENTORS AND MENTEES 5279 03:14:29,882 --> 03:14:32,251 BASED ON FEEDBACK, TANGIBLE DATA 5280 03:14:32,251 --> 03:14:33,919 WE COLLECT, AND PREFERENCE FROM 5281 03:14:33,919 --> 03:14:36,989 MENTEES AND MENTORS. 5282 03:14:36,989 --> 03:14:38,891 THIS INVESTMENT IN MENTORSHIP 5283 03:14:38,891 --> 03:14:41,827 PAIRING PAID GREAT DIFFERENCE AS 5284 03:14:41,827 --> 03:14:44,029 INDICATED IN SURVEY DATA, 5285 03:14:44,029 --> 03:14:48,167 ANECDOTAL DATA, PROGRAM AND 5286 03:14:48,167 --> 03:14:51,904 TRAINING GOALS AND BONDING WE 5287 03:14:51,904 --> 03:14:52,972 EXPERIENCED. 5288 03:14:52,972 --> 03:14:53,539 WE FACILITATE MEANINGFUL 5289 03:14:53,539 --> 03:14:55,174 INTERACTIONS FOCUSED ON RESEARCH 5290 03:14:55,174 --> 03:14:58,344 AND PROFESSIONAL DEVELOPMENT BUT 5291 03:14:58,344 --> 03:15:02,948 AGAIN WE ALSO EMPHASIZE THIS 5292 03:15:02,948 --> 03:15:06,218 ONE-ON-ONE MENTORSHIP IS 5293 03:15:06,218 --> 03:15:10,356 SUPPORTED IN MORE BROAD SMALL 5294 03:15:10,356 --> 03:15:12,691 GROUP, COMMUNITY AND FLIPPED 5295 03:15:12,691 --> 03:15:13,258 MENTORSHIP. 5296 03:15:13,258 --> 03:15:16,595 THESE ARE SOME SMALL GROUP AND 5297 03:15:16,595 --> 03:15:18,897 PEER MENTORSHIP GROUPS WE 5298 03:15:18,897 --> 03:15:20,099 FACILITATED. 5299 03:15:20,099 --> 03:15:22,501 WE KNOW FROM RESEARCH AND 5300 03:15:22,501 --> 03:15:24,069 ANECDOTAL EVIDENCE THAT HELPED 5301 03:15:24,069 --> 03:15:25,270 DEVELOP STRONGER BONDS AND SENSE 5302 03:15:25,270 --> 03:15:26,939 OF COMMUNITY THAT WE THINK IS 5303 03:15:26,939 --> 03:15:28,574 ONE OF THE THINGS THAT MAKES 5304 03:15:28,574 --> 03:15:30,209 THIS PROGRAM SPECIAL AND ONE OF 5305 03:15:30,209 --> 03:15:32,077 THE THINGS WE WOULD ADVOCATE 5306 03:15:32,077 --> 03:15:34,179 FOR, FOR RESEARCH PROGRAMS 5307 03:15:34,179 --> 03:15:35,581 MOVING FORWARD, RESEARCH 5308 03:15:35,581 --> 03:15:36,315 EDUCATION PROGRAMS MOVING 5309 03:15:36,315 --> 03:15:45,858 FORWARD, SENSE OF BELONGING AND 5310 03:15:45,858 --> 03:15:46,525 COMMUNITY. 5311 03:15:46,525 --> 03:15:49,795 WE MADE INVESTMENT IN COMMUNITY 5312 03:15:49,795 --> 03:15:51,563 BUILDING, THE MOTIF OF THIS 5313 03:15:51,563 --> 03:15:51,797 PROGRAM. 5314 03:15:51,797 --> 03:15:57,002 AND I'LL SPEAK MORE ABOUT THAT 5315 03:15:57,002 --> 03:15:57,202 LATER. 5316 03:15:57,202 --> 03:15:58,871 AFTER THE INTENSIVE ONE-WEEK 5317 03:15:58,871 --> 03:16:01,607 TRAINING WE GO VIRTUAL, THE 5318 03:16:01,607 --> 03:16:03,442 SECOND PHASE INCLUDES NINE 5319 03:16:03,442 --> 03:16:07,212 MONTHLY GROUP SESSION, 30 5320 03:16:07,212 --> 03:16:11,784 INDIVIDUALS, INCLUDING TRAINEES, 5321 03:16:11,784 --> 03:16:13,352 MENTORS AND ADMINISTRATORS 5322 03:16:13,352 --> 03:16:14,253 ATTEND SESSIONS, WE DESIGNED 5323 03:16:14,253 --> 03:16:17,356 THIS TO SUSTAIN THE SAME LEVEL 5324 03:16:17,356 --> 03:16:18,557 OF PEDAGOGY ENGAGEMENT AND 5325 03:16:18,557 --> 03:16:20,526 COLLABORATION WE WERE ABLE TO 5326 03:16:20,526 --> 03:16:24,563 ACHIEVE DURING THE IN-PERSON 5327 03:16:24,563 --> 03:16:25,264 CONFERENCE. 5328 03:16:25,264 --> 03:16:27,566 YES, WE GO OVERBOARD WITH THE 5329 03:16:27,566 --> 03:16:30,069 BACKGROUNDS A LITTLE BIT. 5330 03:16:30,069 --> 03:16:33,138 THE MONTHLY SESSIONS INCLUDE 5331 03:16:33,138 --> 03:16:34,673 GROUP MEETINGS, COMMUNITY 5332 03:16:34,673 --> 03:16:36,709 BUILDING ACTIVITIES AND BONDING 5333 03:16:36,709 --> 03:16:38,377 ACTIVITIES, 45 TO 60 MINUTES OF 5334 03:16:38,377 --> 03:16:40,145 ONE-ON-ONE PROTECTED TIME WITH 5335 03:16:40,145 --> 03:16:45,584 THEIR MENTORS, ALSO TIME TO 5336 03:16:45,584 --> 03:16:47,019 PRESENT RESEARCH AND PROVIDE 5337 03:16:47,019 --> 03:16:47,920 STATUS UPDATES. 5338 03:16:47,920 --> 03:16:49,755 WE HAVE OPEN DISCUSSIONS WITH 5339 03:16:49,755 --> 03:16:50,322 PEERS AND SENIOR COLLEAGUES 5340 03:16:50,322 --> 03:16:53,726 WHERE THEY CAN PROVIDE FEEDBACK, 5341 03:16:53,726 --> 03:16:56,562 GUIDANCE, RESOURCES, 5342 03:16:56,562 --> 03:16:56,895 ENCOURAGEMENT. 5343 03:16:56,895 --> 03:16:58,430 THESE SESSIONS, THE START 5344 03:16:58,430 --> 03:17:01,467 SCHOLARS PROGRESS FROM JUST 5345 03:17:01,467 --> 03:17:04,203 AGAIN THAT VERY ELEMENTARY 5346 03:17:04,203 --> 03:17:05,637 ANALYTICAL PLAN FOR FOUR 5347 03:17:05,637 --> 03:17:08,040 RESEARCH STUDIES ACROSS EIGHT 5348 03:17:08,040 --> 03:17:08,273 MONTHS. 5349 03:17:08,273 --> 03:17:12,411 EACH SESSION HAS SPECIFIC 5350 03:17:12,411 --> 03:17:13,178 LEARNING OBJECTIVES, SPECIFIC 5351 03:17:13,178 --> 03:17:17,249 DELIVERABLES TO MEASURE MASTERY 5352 03:17:17,249 --> 03:17:19,651 OF THOSE OBJECTIVES. 5353 03:17:19,651 --> 03:17:24,656 THE THIRD AND FINAL PHASE IS 5354 03:17:24,656 --> 03:17:26,125 DISSEMINATION AND PROFESSIONAL, 5355 03:17:26,125 --> 03:17:27,226 DEMONSTRATING RIGOR, MERIT, 5356 03:17:27,226 --> 03:17:29,495 POTENTIAL FOR PUBLIC IMPACT. 5357 03:17:29,495 --> 03:17:30,996 THEY PRESENT RESEARCH AT THE 5358 03:17:30,996 --> 03:17:33,098 INTERNAL START SESSIONS AS WELL 5359 03:17:33,098 --> 03:17:34,533 AS AT THE PUBLIC START 5360 03:17:34,533 --> 03:17:36,268 DISSEMINATION CONFERENCE WHERE 5361 03:17:36,268 --> 03:17:38,003 WE INVITE COMMUNITY MEMBERS, 5362 03:17:38,003 --> 03:17:38,904 COLLEAGUES, FOLKS TO SEE WHAT 5363 03:17:38,904 --> 03:17:41,640 WE'RE DOING AND HOW WE'RE USING 5364 03:17:41,640 --> 03:17:43,075 OUR RESOURCES AND ABILITYING TO 5365 03:17:43,075 --> 03:17:47,613 SERVE REAL FAMILIES AND REAL 5366 03:17:47,613 --> 03:17:47,913 COMMUNITIES. 5367 03:17:47,913 --> 03:17:49,681 THEY ALSO PRESENT RESEARCH AT 5368 03:17:49,681 --> 03:17:53,051 OTHER CONFERENCES SUCH AS CPDD, 5369 03:17:53,051 --> 03:17:55,053 APA, AIMS, ABCD, AND OTHER 5370 03:17:55,053 --> 03:17:56,255 CONFERENCES AROUND THE COUNTRY 5371 03:17:56,255 --> 03:18:03,562 AND THE WORLD. 5372 03:18:03,562 --> 03:18:06,198 5373 03:18:06,198 --> 03:18:07,166 5374 03:18:07,166 --> 03:18:09,268 THIS FEATURES GRANTSMANSHIP 5375 03:18:09,268 --> 03:18:11,670 TRAINING, DATA INDICATED THAT 5376 03:18:11,670 --> 03:18:12,304 PARTICIPATION FROM NIH OFFICERS 5377 03:18:12,304 --> 03:18:15,107 WAS ONE OF THE MOST IMPACTFUL 5378 03:18:15,107 --> 03:18:16,809 AND VALUABLE COMPONENTS OF THE 5379 03:18:16,809 --> 03:18:17,609 PROGRAM ACCORDING TO THE 5380 03:18:17,609 --> 03:18:17,910 TRAINEES. 5381 03:18:17,910 --> 03:18:21,113 I WANT TO TAKE A MOMENT SAY WE 5382 03:18:21,113 --> 03:18:22,314 REALLY APPRECIATE THESE SPECIFIC 5383 03:18:22,314 --> 03:18:24,383 OFFICERS WHO SUPPORTED THIS 5384 03:18:24,383 --> 03:18:25,050 PROGRAM WHO VOLUNTEERED GIVE 5385 03:18:25,050 --> 03:18:25,684 SOME TRAINING. 5386 03:18:25,684 --> 03:18:30,189 BUT ALL THE OTHER OFFICERS AND 5387 03:18:30,189 --> 03:18:32,825 PERSONNEL WHO ENGAGED IN THIS, 5388 03:18:32,825 --> 03:18:33,292 EARLY CAREER SCHOLARS. 5389 03:18:33,292 --> 03:18:35,561 THIS WAS ONE OF THE TOP POINTS 5390 03:18:35,561 --> 03:18:38,430 OF FEEDBACK WE GOT THAT THEY 5391 03:18:38,430 --> 03:18:40,399 APPRECIATED ABOUT OUR PROGRAM. 5392 03:18:40,399 --> 03:18:41,900 THEY REALLY VALUED THE 5393 03:18:41,900 --> 03:18:47,239 OPPORTUNITY TO INTERACT WITH NIH 5394 03:18:47,239 --> 03:18:47,840 OFFICERS. 5395 03:18:47,840 --> 03:18:50,776 AND A PART OF THIS PROGRAM IS 5396 03:18:50,776 --> 03:18:51,977 CONSTANT EVALUATION. 5397 03:18:51,977 --> 03:18:55,614 WE FREQUENTLY COLLECT AND 5398 03:18:55,614 --> 03:18:57,649 ANALYZE DATA, IN FORMAL FEEDBACK 5399 03:18:57,649 --> 03:18:59,518 AS PART OF CONTINUING 5400 03:18:59,518 --> 03:19:00,085 IMPROVEMENT PLAN, INFORMING 5401 03:19:00,085 --> 03:19:02,254 IMPLEMENTATION OF THE PROGRAM 5402 03:19:02,254 --> 03:19:04,122 BUT ALSO MODIFICATIONS, IT 5403 03:19:04,122 --> 03:19:05,891 GUIDES OUR LONG-TERM DEVELOPMENT 5404 03:19:05,891 --> 03:19:07,326 OF THIS PROGRAM. 5405 03:19:07,326 --> 03:19:09,094 DATA INDICATED THE PROGRAM 5406 03:19:09,094 --> 03:19:11,263 ENHANCED KNOWLEDGE AND SKILLS, 5407 03:19:11,263 --> 03:19:12,798 ANTICIPATED THAT, BUT ALSO 5408 03:19:12,798 --> 03:19:14,333 HELPED TO ADDRESS SOME OF THE 5409 03:19:14,333 --> 03:19:16,501 INTERNAL AND SOCIAL BARRIERS 5410 03:19:16,501 --> 03:19:19,671 THAT MANY SCHOLARS FACE AND FEEL 5411 03:19:19,671 --> 03:19:21,340 WHEN THEY PURSUE RESEARCH 5412 03:19:21,340 --> 03:19:21,573 CAREERS. 5413 03:19:21,573 --> 03:19:24,810 I WANT TO SHARE SOME OF THE 5414 03:19:24,810 --> 03:19:27,246 FEEDBACK WITH YOU. 5415 03:19:27,246 --> 03:19:29,314 THE FORMAL SURVEY DATA PROVIDES 5416 03:19:29,314 --> 03:19:29,982 INVALUABLE INFORMATION. 5417 03:19:29,982 --> 03:19:32,484 HOWEVER, THE MOST COMPELLING 5418 03:19:32,484 --> 03:19:35,754 FEEDBACK CAME FROM VOLUNTARY 5419 03:19:35,754 --> 03:19:36,521 INFORMAL NOTES TRAINEES FROM THE 5420 03:19:36,521 --> 03:19:38,223 PROGRAM TOOK IT UPON THEMSELVES 5421 03:19:38,223 --> 03:19:42,361 TO CREATE AND SEND US. 5422 03:19:42,361 --> 03:19:43,462 UNPROVOKED, THEY DECIDED TO 5423 03:19:43,462 --> 03:19:45,130 CREATE REFLECTION NOTES AND 5424 03:19:45,130 --> 03:19:46,031 POINTS OF FEEDBACK. 5425 03:19:46,031 --> 03:19:49,635 WE WERE NERVOUS BUT THEY WERE 5426 03:19:49,635 --> 03:19:49,968 POSITIVE. 5427 03:19:49,968 --> 03:19:52,704 I'LL READ RAW NOTES TO GIVE A 5428 03:19:52,704 --> 03:19:53,906 GLIMPSE INTO VARIOUS EXPERIENCES 5429 03:19:53,906 --> 03:19:56,108 AND POTENTIAL FOR THIS PROGRAM 5430 03:19:56,108 --> 03:19:58,810 TO MAKE A LASTING IMPACT ON THE 5431 03:19:58,810 --> 03:20:00,245 SCHOLARS THAT MATRICULATE 5432 03:20:00,245 --> 03:20:01,246 THROUGH AND FOLKS THAT 5433 03:20:01,246 --> 03:20:06,051 PARTICIPATE IN IT, THE MENTORS, 5434 03:20:06,051 --> 03:20:06,485 OURSELVES, EVERYONE. 5435 03:20:06,485 --> 03:20:09,922 THIS WEEK EMBODIED AUTHENTIC 5436 03:20:09,922 --> 03:20:10,689 MENTORSHIP, COLLABORATION, 5437 03:20:10,689 --> 03:20:11,356 SHARED OPPORTUNITIES FOR THOSE 5438 03:20:11,356 --> 03:20:16,795 OF US WHO OFTEN FEEL FORGOTTEN, 5439 03:20:16,795 --> 03:20:17,296 UNDERVALUED, INVISIBLE. 5440 03:20:17,296 --> 03:20:22,067 YOU CULTIVATED SAFETY, RENNE -- 5441 03:20:22,067 --> 03:20:30,742 RENNE REINFORCED OUR VALUE. 5442 03:20:30,742 --> 03:20:31,977 I CONSIDER MY SCIENTIFIC FAMILY 5443 03:20:31,977 --> 03:20:33,812 NOW WITH THIS NEW FAMILY THAT 5444 03:20:33,812 --> 03:20:36,315 YOU'VE ALLOWED US TO BUILD, I 5445 03:20:36,315 --> 03:20:38,850 FEEL SUPPORTED, INSPIRED, AND 5446 03:20:38,850 --> 03:20:41,053 MORE CONFIDENT IN NAVIGATING THE 5447 03:20:41,053 --> 03:20:42,254 INTIMIDATING ACADEMIC WORLD 5448 03:20:42,254 --> 03:20:46,158 WE'RE WORKING IN. 5449 03:20:46,158 --> 03:20:48,026 AND THIS ONE-YEAR PROGRAM HAD 5450 03:20:48,026 --> 03:20:50,329 NOT ONLY ACCESS TO DATA HANDS-ON 5451 03:20:50,329 --> 03:20:51,964 TRAINING, KNOWLEDGE ON DATA 5452 03:20:51,964 --> 03:20:53,198 COLLECTION, BUT ALSO MORE 5453 03:20:53,198 --> 03:20:54,499 IMPORTANTLY HAD A CHANCE TO 5454 03:20:54,499 --> 03:20:56,902 BECOME PART OF THIS BRILLIANT 5455 03:20:56,902 --> 03:20:58,570 COMMUNITY, HAD PROFOUND SENSE OF 5456 03:20:58,570 --> 03:21:01,106 BELONGING THIS WEEK, WHICH I 5457 03:21:01,106 --> 03:21:03,809 RARELY EXPERIENCE. 5458 03:21:03,809 --> 03:21:08,413 EACH YEAR FOR THE NEXT FOUR YEAR 5459 03:21:08,413 --> 03:21:11,183 WE'LL BE ENROLLING TRAINEES, 5460 03:21:11,183 --> 03:21:13,218 MENTORS, FOCUSING ON 5461 03:21:13,218 --> 03:21:14,152 DISSEMINATION, PUBLISHING 5462 03:21:14,152 --> 03:21:15,120 RESEARCH, DISSEMINATING BEST 5463 03:21:15,120 --> 03:21:17,322 PRACTICES WE'RE LEARNING FROM 5464 03:21:17,322 --> 03:21:18,490 THIS PROGRAM. 5465 03:21:18,490 --> 03:21:21,460 WE WILL CONTINUE TO IMPROVE AND 5466 03:21:21,460 --> 03:21:23,128 REFINE THIS PROGRAM TO MAKE SURE 5467 03:21:23,128 --> 03:21:25,430 WE'RE MARCHING TOWARD A WORLD 5468 03:21:25,430 --> 03:21:27,232 CLASS RESEARCH EDUCATION 5469 03:21:27,232 --> 03:21:27,632 PROGRAM. 5470 03:21:27,632 --> 03:21:30,902 WE HOPE TO EXPAND THIS MODEL, 5471 03:21:30,902 --> 03:21:32,437 IMPLEMENT SIMILAR PROGRAMS IN 5472 03:21:32,437 --> 03:21:33,872 OTHER RESEARCH COMMUNITIES AND 5473 03:21:33,872 --> 03:21:36,141 CONSORTIA. 5474 03:21:36,141 --> 03:21:37,442 5475 03:21:37,442 --> 03:21:39,745 JUST A SHORT WHILE WE'VE 5476 03:21:39,745 --> 03:21:42,247 OBSERVED THE POTENTIAL FOR THE 5477 03:21:42,247 --> 03:21:45,751 START PROGRAM TO ENHANCE ABCD 5478 03:21:45,751 --> 03:21:48,286 COMMUNITY AND SUPPORT SCIENTIFIC 5479 03:21:48,286 --> 03:21:48,587 INNOVATION. 5480 03:21:48,587 --> 03:21:53,425 WE ANTICIPATED THAT, BUT WE DID 5481 03:21:53,425 --> 03:21:55,627 NOT ANTICIPATE THIS REALLY 5482 03:21:55,627 --> 03:21:57,929 DEEPLY PROFOUND SENSE OF 5483 03:21:57,929 --> 03:21:58,330 CONNECTION. 5484 03:21:58,330 --> 03:21:58,830 THERE WAS UNMEASURABLE 5485 03:21:58,830 --> 03:22:01,299 METAPHYSICAL QUALITY THAT WAS 5486 03:22:01,299 --> 03:22:02,234 PRESENT, IT WAS THIS HUMAN 5487 03:22:02,234 --> 03:22:03,702 CONNECTION, SENSE OF COMMUNITY. 5488 03:22:03,702 --> 03:22:08,173 CREATED A SPACE WHERE FOLKS 5489 03:22:08,173 --> 03:22:09,074 BELONGED, FELT VALUED, 5490 03:22:09,074 --> 03:22:10,242 SUPPORTED, PROVIDED TOOLS TO BE 5491 03:22:10,242 --> 03:22:11,810 SUCCESSFUL, SPACE WHERE THEY 5492 03:22:11,810 --> 03:22:14,546 WERE ALLOWED TO GROW, ALLOWED TO 5493 03:22:14,546 --> 03:22:17,516 BE IMPERFECT, BUT ALSO ALLOWED 5494 03:22:17,516 --> 03:22:19,051 TO BE BRILLIANT. 5495 03:22:19,051 --> 03:22:23,188 WE CREATED A FACE FOLKS COULD DO 5496 03:22:23,188 --> 03:22:24,289 RIGOROUS INTENT IMPACTFUL 5497 03:22:24,289 --> 03:22:27,159 RESEARCH WITH JOY, RELATIVE 5498 03:22:27,159 --> 03:22:28,794 BALANCE, CONNECTION, COMMUNITY, 5499 03:22:28,794 --> 03:22:29,628 AND CARE. 5500 03:22:29,628 --> 03:22:30,629 WE'RE STILL IN THE EARLY STAGES 5501 03:22:30,629 --> 03:22:31,630 OF THIS PROGRAM. 5502 03:22:31,630 --> 03:22:33,832 WE STILL HAVE MUCH WORK TO DO 5503 03:22:33,832 --> 03:22:35,233 BUT WE'VE ALREADY MADE 5504 03:22:35,233 --> 03:22:36,601 SIGNIFICANT STRIDES AND I HAVE A 5505 03:22:36,601 --> 03:22:38,670 DEEP PASSION FOR THIS WORK AND 5506 03:22:38,670 --> 03:22:40,305 MY COLLEAGUES AND I AGAIN ARE 5507 03:22:40,305 --> 03:22:42,941 DETERMINED TO CREATE A WORLD 5508 03:22:42,941 --> 03:22:44,810 CLASS RESEARCH EDUCATION PROGRAM 5509 03:22:44,810 --> 03:22:46,445 THAT EQUIPS GIFTED SCIENTISTS 5510 03:22:46,445 --> 03:22:48,413 WITH THE TOOLS NEEDED TO 5511 03:22:48,413 --> 03:22:50,715 SAFEGUARD HEALTH AND WELLNESS 5512 03:22:50,715 --> 03:22:52,017 FOR FUTURE GENERATIONS. 5513 03:22:52,017 --> 03:22:54,419 AGAIN, AN IMPORTANT ASPECT OF 5514 03:22:54,419 --> 03:22:55,954 THIS MODEL IS COMPASSION AND 5515 03:22:55,954 --> 03:22:58,924 COMMUNITY SO THERE'S CONFLICT IN 5516 03:22:58,924 --> 03:22:59,758 THE WORLD, SUFFERING, 5517 03:22:59,758 --> 03:23:00,559 UNCERTAINTY, IN OUR OWN LIVES 5518 03:23:00,559 --> 03:23:04,296 AND LIVES OF THE FAMILIES 5519 03:23:04,296 --> 03:23:06,164 COMMUNITIES WE SEEK TO SERVE. 5520 03:23:06,164 --> 03:23:07,365 THIS PROGRAM HAS POTENTIAL TO 5521 03:23:07,365 --> 03:23:08,800 HELP FOLKS FROM DIVERSE 5522 03:23:08,800 --> 03:23:10,435 BACKGROUNDS AND PERSPECTIVES TO 5523 03:23:10,435 --> 03:23:13,171 GET ENGAGED, TO GET INVOLVED, TO 5524 03:23:13,171 --> 03:23:16,007 USE THEIR TALENTS AND ABILITIES 5525 03:23:16,007 --> 03:23:17,542 AND EXPERIENCES TO SUPPORT 5526 03:23:17,542 --> 03:23:19,077 COMMUNITIES THAT LOOK LIKE THEM, 5527 03:23:19,077 --> 03:23:21,279 SUPPORT THE COMMUNITIES THEY 5528 03:23:21,279 --> 03:23:26,118 COME FROM. 5529 03:23:26,118 --> 03:23:32,657 SO I BELIEVE THAT COMMUNITY MAY 5530 03:23:32,657 --> 03:23:35,293 BE A SECRET INGREDIENT IN 5531 03:23:35,293 --> 03:23:36,161 UNLOCKING POTENTIAL, ELIMINATING 5532 03:23:36,161 --> 03:23:37,796 DISPARITIES, IMPROVING QUALITY 5533 03:23:37,796 --> 03:23:39,564 OF LIFE FOR SCIENTIFIC 5534 03:23:39,564 --> 03:23:39,831 COMMUNITY. 5535 03:23:39,831 --> 03:23:41,399 AS WELL AS COMMUNITIES AND 5536 03:23:41,399 --> 03:23:42,334 FAMILIES WE SERVE. 5537 03:23:42,334 --> 03:23:44,035 IN CLOSING I WANT TO SAY THAT 5538 03:23:44,035 --> 03:23:46,771 THE NEXT GENERATION IS WATCHING. 5539 03:23:46,771 --> 03:23:48,206 THEY ARE EXCITED. 5540 03:23:48,206 --> 03:23:49,708 ENCOURAGED, EAGER TO GET 5541 03:23:49,708 --> 03:23:50,041 INVOLVED. 5542 03:23:50,041 --> 03:23:55,981 THIS IS A GROUP OF STUDENTS FROM 5543 03:23:55,981 --> 03:23:57,415 THE SCIENTIFIC ADDICTION 5544 03:23:57,415 --> 03:23:58,950 RESEARCH TRAINING, R25 SUPPORTED 5545 03:23:58,950 --> 03:24:01,686 BY NIDA, ATTENDED THE START 5546 03:24:01,686 --> 03:24:03,622 SYMPOSIUM, ABCD START SYMPOSIUM 5547 03:24:03,622 --> 03:24:05,524 AND THEY WERE COMPLETELY 5548 03:24:05,524 --> 03:24:10,095 CONVINCED THAT THEY WERE CAPABLE 5549 03:24:10,095 --> 03:24:11,863 OF WRANGLING THE ABCD DATASET 5550 03:24:11,863 --> 03:24:13,398 AND GET INVOLVED IMMEDIATELY. 5551 03:24:13,398 --> 03:24:15,167 THEY WANT OPPORTUNITIES TO LEARN 5552 03:24:15,167 --> 03:24:16,468 MORE ABOUT THIS STUDY AND BE 5553 03:24:16,468 --> 03:24:17,669 MORE INVOLVED WITH THE DATA. 5554 03:24:17,669 --> 03:24:21,173 SO WE NEED TO THINK ABOUT WAYS 5555 03:24:21,173 --> 03:24:22,207 TO INVOLVE FUTURE SCHOLARS IN 5556 03:24:22,207 --> 03:24:25,043 THIS STUDY VERY EARLY IN THEIR 5557 03:24:25,043 --> 03:24:27,212 CAREERS, ESPECIALLY THOSE WHO 5558 03:24:27,212 --> 03:24:28,947 IDENTIFY AND REPRESENT 5559 03:24:28,947 --> 03:24:29,981 POPULATIONS DISPROPORTIONATELY 5560 03:24:29,981 --> 03:24:31,716 IMPACTED BY SUBSTANCE ISSUES. 5561 03:24:31,716 --> 03:24:33,885 I'LL BE THINKING ABOUT WAYS TO 5562 03:24:33,885 --> 03:24:34,786 DO THAT. 5563 03:24:34,786 --> 03:24:38,056 AND WAYS WE CAN GET THEM 5564 03:24:38,056 --> 03:24:40,692 INVOLVES. 5565 03:24:40,692 --> 03:24:40,959 INVOLVED. 5566 03:24:40,959 --> 03:24:45,497 I THANK NIDA, DR. DOWLING, DR. 5567 03:24:45,497 --> 03:24:49,668 LOPEZ, START CO-P.I.S, DR. 5568 03:24:49,668 --> 03:24:57,209 POTTER AND GARAVAN, THE ABCD 5569 03:24:57,209 --> 03:24:58,843 CONSORTIUM, ARIA CRUMP, I'M AN 5570 03:24:58,843 --> 03:25:00,512 ALUMNUS OF THE NIDA DIVERSITY 5571 03:25:00,512 --> 03:25:02,414 SCHOLARS NETWORK PROGRAM AND 5572 03:25:02,414 --> 03:25:04,216 NONE OF THIS WOULD HAVE BEEN 5573 03:25:04,216 --> 03:25:11,022 POSSIBLE WITHOUT MY 5574 03:25:11,022 --> 03:25:21,566 PARTICIPATION IN THAT PROGRAM. 5575 03:25:23,568 --> 03:25:29,174 ARE THERE ANY QUESTIONS? 5576 03:25:29,174 --> 03:25:32,143 >> GO AHEAD, TINA. 5577 03:25:32,143 --> 03:25:33,578 >> MICAH, THAT WAS FANTASTIC. 5578 03:25:33,578 --> 03:25:34,946 I LOVE THE PROGRAM. 5579 03:25:34,946 --> 03:25:39,017 CAN YOU SAY HOW YOUR FIRST 5580 03:25:39,017 --> 03:25:40,118 COHORT OF PILOT TRAINEES MIGHT 5581 03:25:40,118 --> 03:25:42,754 CONTRIBUTE TO THE NEXT COHORT OR 5582 03:25:42,754 --> 03:25:46,992 FUTURE COHORTS? 5583 03:25:46,992 --> 03:25:47,525 >> REALLY GOOD QUESTION. 5584 03:25:47,525 --> 03:25:52,797 100 PER CENT SIGNED UP TO BE 5585 03:25:52,797 --> 03:25:53,898 MENTORS FOR THE NEXT COHORT. 5586 03:25:53,898 --> 03:25:56,301 AND SO AS OF RIGHT NOW THEY ARE 5587 03:25:56,301 --> 03:25:58,770 SERVING AS PEER MENTORS, 5588 03:25:58,770 --> 03:25:59,804 INFORMAL CAPACITY. 5589 03:25:59,804 --> 03:26:01,673 IN THE FUTURE WE SEE THEM 5590 03:26:01,673 --> 03:26:02,907 SERVING AS MENTORS. 5591 03:26:02,907 --> 03:26:04,276 THERE'S BEEN A LOT OF 5592 03:26:04,276 --> 03:26:06,044 COLLABORATION NOT JUST BETWEEN 5593 03:26:06,044 --> 03:26:07,178 PILOT COHORT AND INAUGURAL, 5594 03:26:07,178 --> 03:26:09,748 FIRST COHORT IN THE FULL PROGRAM 5595 03:26:09,748 --> 03:26:11,216 BUT ALSO THERE'S BEEN 5596 03:26:11,216 --> 03:26:13,785 COLLABORATIONS BETWEEN THE PILOT 5597 03:26:13,785 --> 03:26:15,687 COHORT AND THE UNDERGRADUATE 5598 03:26:15,687 --> 03:26:16,187 STUDENTS WHO ATTENDED. 5599 03:26:16,187 --> 03:26:18,056 THIS IS HAPPENING IN A WAY 5600 03:26:18,056 --> 03:26:21,559 THAT'S REALLY AWESOME AND 5601 03:26:21,559 --> 03:26:22,394 MAGICAL. 5602 03:26:22,394 --> 03:26:23,928 >> THAT WAS GREAT. 5603 03:26:23,928 --> 03:26:26,097 I WAS WONDERING IF YOU CAN SAY 5604 03:26:26,097 --> 03:26:29,167 MORE ABOUT HOW YOU RECRUIT, 5605 03:26:29,167 --> 03:26:32,037 WHERE YOU RECRUIT THE CANDIDATES 5606 03:26:32,037 --> 03:26:33,638 AND ALSO WHAT HAPPENS AFTER. 5607 03:26:33,638 --> 03:26:35,240 YES, THEY ALL WANT TO BE MENTORS 5608 03:26:35,240 --> 03:26:39,611 BUT IN TERMS OF THEIR OWN CAREER 5609 03:26:39,611 --> 03:26:40,111 DEVELOPMENT, BECAUSE I'M 5610 03:26:40,111 --> 03:26:44,382 WONDERING IF THERE'S A WAY TO 5611 03:26:44,382 --> 03:26:46,284 INTERDIGITATE WITH NIDA, THE TWO 5612 03:26:46,284 --> 03:26:47,919 PROGRAMS, K PROGRAMS, THOSE 5613 03:26:47,919 --> 03:26:49,688 KINDS OF THINGS, BECAUSE WE 5614 03:26:49,688 --> 03:26:52,857 WOULD LOVE TO ENGAGE SCIENTISTS 5615 03:26:52,857 --> 03:26:54,259 IN THE BROADER COMMUNITY BEYOND 5616 03:26:54,259 --> 03:26:58,730 ABCD AS WELL. 5617 03:26:58,730 --> 03:27:00,732 >> EXCELLENT, EXCELLENT 5618 03:27:00,732 --> 03:27:01,933 QUESTION. 5619 03:27:01,933 --> 03:27:02,133 OKAY. 5620 03:27:02,133 --> 03:27:05,537 NUMBER ONE, WE THINK A LOT ABOUT 5621 03:27:05,537 --> 03:27:07,272 FOLLOW-UP AND WHAT COMES NEXT 5622 03:27:07,272 --> 03:27:10,008 FOR THE FOLKS WHO COME THROUGH 5623 03:27:10,008 --> 03:27:10,709 THE PROGRAM. 5624 03:27:10,709 --> 03:27:12,410 WE SEE START AS A FEEDER 5625 03:27:12,410 --> 03:27:16,381 PROGRAM, SOME GOING INTO T32 5626 03:27:16,381 --> 03:27:17,449 PROGRAM, SOME PURSUING K01S AND 5627 03:27:17,449 --> 03:27:19,551 R01S AND THINGS OF THAT NATURE. 5628 03:27:19,551 --> 03:27:21,086 FOR EACH PERSON IT'S MORE 5629 03:27:21,086 --> 03:27:22,187 INDIVIDUALIZED THAN TAILORED BUT 5630 03:27:22,187 --> 03:27:24,122 WE SEE OURSELVES AS A FEEDER 5631 03:27:24,122 --> 03:27:24,356 PROGRAM. 5632 03:27:24,356 --> 03:27:25,657 WE'RE MAKING SURE WE HAND THEM 5633 03:27:25,657 --> 03:27:28,827 OFF TO THE ABCD CONSORTIUM AND 5634 03:27:28,827 --> 03:27:29,094 COMMUNITY. 5635 03:27:29,094 --> 03:27:30,261 WE TRY TO FACILITATE THEIR 5636 03:27:30,261 --> 03:27:31,463 PARTICIPATION IN WORK GROUPS 5637 03:27:31,463 --> 03:27:33,431 THAT WOULD GIVE THEM MORE ACCESS 5638 03:27:33,431 --> 03:27:36,301 TO BE MORE ENGAGED AND BE 5639 03:27:36,301 --> 03:27:37,936 INVOLVED IN ABCD COMMUNITY. 5640 03:27:37,936 --> 03:27:39,237 SO THOSE ARE THE TWO 5641 03:27:39,237 --> 03:27:40,772 PROFESSIONAL WAYS WE DO THINGS. 5642 03:27:40,772 --> 03:27:41,973 WE HELP THEM ACHIEVE THEIR GOALS 5643 03:27:41,973 --> 03:27:44,409 AND HAND THEM OFF TO A 5644 03:27:44,409 --> 03:27:45,377 COMMUNITY. 5645 03:27:45,377 --> 03:27:47,679 BEYOND THAT, WE SERVE AS 5646 03:27:47,679 --> 03:27:49,013 LIFELONG PEERS, COLLABORATORS, 5647 03:27:49,013 --> 03:27:50,548 MENTORS FOR THEM. 5648 03:27:50,548 --> 03:27:52,617 WE STILL MEET REGULARLY WITH 5649 03:27:52,617 --> 03:27:57,555 ALUMNI, COLLABORATE ON PAPERS, 5650 03:27:57,555 --> 03:28:02,026 WE'RE PART OF THAT PROFESSIONAL 5651 03:28:02,026 --> 03:28:02,360 COMMUNITY. 5652 03:28:02,360 --> 03:28:04,629 >> THAT WAS SUPERB BUT I THINK 5653 03:28:04,629 --> 03:28:06,631 WE'RE GOING TO MOVE ON AND WE 5654 03:28:06,631 --> 03:28:09,467 WILL HAVE A HALF AN HOUR AT THE 5655 03:28:09,467 --> 03:28:11,202 END FOR DISCUSSION SO SAVE YOUR 5656 03:28:11,202 --> 03:28:13,071 QUESTIONS FOR OUR SPEAKERS AT 5657 03:28:13,071 --> 03:28:13,738 THAT TIME. 5658 03:28:13,738 --> 03:28:18,109 >> I WANT TO SAY WE WANT TO 5659 03:28:18,109 --> 03:28:19,978 PERPETUATE THIS EVERY PROGRAM, 5660 03:28:19,978 --> 03:28:23,615 CAN'T JUST BE ABCD, WE NEED TO 5661 03:28:23,615 --> 03:28:26,117 CLONE MICAH. 5662 03:28:26,117 --> 03:28:27,952 5663 03:28:27,952 --> 03:28:33,224 >> MY PLEASURE TO INTRODUCE 5664 03:28:33,224 --> 03:28:35,960 FAITH ADAMS, A FOURTH YEAR 5665 03:28:35,960 --> 03:28:38,663 NEUROSCIENCE Ph.D. CANDIDATE 5666 03:28:38,663 --> 03:28:42,333 AT THE ICAHN SCHOOL OF MEDICINE, 5667 03:28:42,333 --> 03:28:44,536 MOUNT SINAI, INFLUENCE OF EARLY 5668 03:28:44,536 --> 03:28:47,472 LIFE EXPERIENCES ON ADOLESCENT 5669 03:28:47,472 --> 03:28:48,139 NEURODEVELOPMENT, PARTICULARLY 5670 03:28:48,139 --> 03:28:49,641 HOW LIFESTYLE, HOME ENVIRONMENT, 5671 03:28:49,641 --> 03:28:51,843 CULTURE, NEIGHBORHOOD, AND 5672 03:28:51,843 --> 03:28:57,615 SCHOOL FACTORS AFFECT THE ONSET 5673 03:28:57,615 --> 03:28:59,517 OF ADOLESCENT SUBSTANCE USE, 5674 03:28:59,517 --> 03:29:01,820 PARTICULARLY ALCOHOL USE, 5675 03:29:01,820 --> 03:29:03,221 EXPLORES THOUSAND NEUROBEHAVIOR 5676 03:29:03,221 --> 03:29:04,022 CORRELATES MEDIATE THESE 5677 03:29:04,022 --> 03:29:06,224 ENVIRONMENTAL IMPACTS ON 5678 03:29:06,224 --> 03:29:09,594 SUBSTANCE USE. 5679 03:29:09,594 --> 03:29:11,196 FAITH WAS AWARDED F31 GRANT FOR 5680 03:29:11,196 --> 03:29:12,564 THIS IMPACTFUL WORK, IN THE 5681 03:29:12,564 --> 03:29:15,533 FUTURE AIMS TO LEVERAGE HER 5682 03:29:15,533 --> 03:29:18,369 EXPERIENCE AND EXPERTISE IN A 5683 03:29:18,369 --> 03:29:19,904 CAREER IN SCIENCE POLICY, 5684 03:29:19,904 --> 03:29:22,640 FOCUSING ON EVIDENCE-BASED 5685 03:29:22,640 --> 03:29:24,275 STRATEGIES TO ENHANCE ADOLESCENT 5686 03:29:24,275 --> 03:29:25,143 HEALTH OUTCOMES. 5687 03:29:25,143 --> 03:29:29,747 SO, FAITH IS GOING TO TALK ABOUT 5688 03:29:29,747 --> 03:29:33,051 ADVANCING PREDICTION OF 5689 03:29:33,051 --> 03:29:42,327 ADOLESCENT ALCOHOL USE ONSET BY 5690 03:29:42,327 --> 03:29:43,228 DERIVING POLYEXPOSURE ALCOHOL 5691 03:29:43,228 --> 03:29:44,395 RISK SCORES. 5692 03:29:44,395 --> 03:29:45,597 >> THANK YOU FOR THIS 5693 03:29:45,597 --> 03:29:46,598 INVITATION, IT'S WONDERFUL BEING 5694 03:29:46,598 --> 03:29:49,534 IN THIS ROOM. 5695 03:29:49,534 --> 03:29:50,301 AND LEARNING MORE ABOUT BEHIND 5696 03:29:50,301 --> 03:29:51,836 THE SCENES OF WHAT EVERYTHING 5697 03:29:51,836 --> 03:29:54,172 LOOKS LIKE AS A Ph.D. STUDENT, 5698 03:29:54,172 --> 03:29:55,340 SOMETIMES YOU DON'T KNOW WHAT 5699 03:29:55,340 --> 03:29:57,308 GOES ON BEHIND THE SCENES SO 5700 03:29:57,308 --> 03:30:01,279 THIS HAS BEEN A VERY GREAT 5701 03:30:01,279 --> 03:30:04,115 INTRODUCTION TO THAT. 5702 03:30:04,115 --> 03:30:06,751 MY PROJECT IS NOT ONLY GOING TO 5703 03:30:06,751 --> 03:30:09,687 FOCUS ON ALCOHOL USE ONSET BUT 5704 03:30:09,687 --> 03:30:12,457 SUBSTANCE USE ONSET SO INCLUSION 5705 03:30:12,457 --> 03:30:15,627 OF DIFFERENT LEGAL SUBSTANCES 5706 03:30:15,627 --> 03:30:18,997 WITHIN THE ABCD STUDY. 5707 03:30:18,997 --> 03:30:20,999 5708 03:30:20,999 --> 03:30:24,068 SO, DR. VOLKOW GAVE A GREAT 5709 03:30:24,068 --> 03:30:25,670 DESCRIPTION, STATISTICS OF WHERE 5710 03:30:25,670 --> 03:30:28,206 WE ARE WITH SUBSTANCE USE IN 5711 03:30:28,206 --> 03:30:28,973 ADOLESCENTS. 5712 03:30:28,973 --> 03:30:32,243 I'M NOT GOING TO BELABOR THIS 5713 03:30:32,243 --> 03:30:36,748 TOO MUCH BUT IN 2023 DATA SHOWED 5714 03:30:36,748 --> 03:30:41,886 THAT 8.3% OF 12 TO 17 YEAR OLDS 5715 03:30:41,886 --> 03:30:42,720 NATIONWIDE REPORTED USING AT 5716 03:30:42,720 --> 03:30:45,590 LEAST ONE DRUG IN THE LAST 5717 03:30:45,590 --> 03:30:50,962 MONTH, AND WHILE ALCOHOL USE HAS 5718 03:30:50,962 --> 03:30:53,264 REMAINED STABLE AMONG EIGHTH 5719 03:30:53,264 --> 03:30:55,133 GRADERS, TENTH GRADERS, AND 5720 03:30:55,133 --> 03:30:57,635 TWELFTH GRADERS, DECLINED FOR 5721 03:30:57,635 --> 03:30:59,270 TWELFTH GRADERS, AND ALSO 5722 03:30:59,270 --> 03:31:01,706 INFORMATION ON NICOTINE VAPING 5723 03:31:01,706 --> 03:31:03,341 WHERE WE'VE SEEN IT REMAINS 5724 03:31:03,341 --> 03:31:04,976 STABLE EVEN THOUGH IT WAS 5725 03:31:04,976 --> 03:31:06,744 RELATIVELY HIGH AND FOR CANNABIS 5726 03:31:06,744 --> 03:31:08,913 USE THIS ALSO REMAINS STABLE. 5727 03:31:08,913 --> 03:31:11,649 SO OVERALL WE SEE THAT 5728 03:31:11,649 --> 03:31:13,418 ADOLESCENTS ARE USING SUBSTANCES 5729 03:31:13,418 --> 03:31:16,588 AND A VERY SMALL PERCENT 5730 03:31:16,588 --> 03:31:17,989 TRANSITION TO SUBSTANCE USE 5731 03:31:17,989 --> 03:31:18,423 DISORDER. 5732 03:31:18,423 --> 03:31:21,059 EVEN THOUGH IT'S A VERY SMALL 5733 03:31:21,059 --> 03:31:23,494 PERCENT, STUDIES DO SHOW EARLIER 5734 03:31:23,494 --> 03:31:25,997 ONSET OF SUBSTANCE USE IS LINKED 5735 03:31:25,997 --> 03:31:30,802 TO INCREASED RISK FOR SUBSTANCE 5736 03:31:30,802 --> 03:31:32,170 USE DISORDERS AND DEPENDENCE. 5737 03:31:32,170 --> 03:31:36,975 I'M GOING TO GO PAST THESE. 5738 03:31:36,975 --> 03:31:42,680 OVERALL, THE IMPORTANCE OF WHAT 5739 03:31:42,680 --> 03:31:44,015 WE'RE SEEING IN TERMS OF THE 5740 03:31:44,015 --> 03:31:48,152 TRENDS OF SUBSTANCE USE IN 5741 03:31:48,152 --> 03:31:49,921 ADOLESCENTS IS INDICATING 5742 03:31:49,921 --> 03:31:51,556 THERE'S AN IMPORTANCE IN 5743 03:31:51,556 --> 03:31:52,256 PRIORITIZING RESEARCH EFFORTS 5744 03:31:52,256 --> 03:31:55,226 AIMED AT DELAYING AGE OF 5745 03:31:55,226 --> 03:31:58,129 SUBSTANCE USE ONSET, TAKELY 5746 03:31:58,129 --> 03:32:00,865 AMONG VULNERABLE YOUTH. 5747 03:32:00,865 --> 03:32:02,400 SO EXTENSIVE RESEARCH HIGHLIGHTS 5748 03:32:02,400 --> 03:32:04,068 GENETICS AND ENVIRONMENT AS 5749 03:32:04,068 --> 03:32:06,004 INFLUENTIAL CONTRIBUTORS TO 5750 03:32:06,004 --> 03:32:08,406 SUBSTANCE USE ONSET AND 5751 03:32:08,406 --> 03:32:10,174 SUBSEQUENT PROBLEMS, GENETIC 5752 03:32:10,174 --> 03:32:12,043 STUDIES SPECIFICALLY SHOW FAMILY 5753 03:32:12,043 --> 03:32:13,778 HISTORY OF SUBSTANCE USE DOUBLES 5754 03:32:13,778 --> 03:32:17,715 RISK OF ONSET AND HIGHER 5755 03:32:17,715 --> 03:32:20,551 POLYGENIC LIABILITY TENDS TO 5756 03:32:20,551 --> 03:32:21,653 PREDICT FASTER TRANSITION TO 5757 03:32:21,653 --> 03:32:23,655 MORE DISORDERED USE. 5758 03:32:23,655 --> 03:32:25,156 ENVIRONMENTAL FACTORS INCLUDE 5759 03:32:25,156 --> 03:32:28,092 LOW PARENTAL MONITORING, SCHOOL 5760 03:32:28,092 --> 03:32:29,060 ENGAGEMENT, NEIGHBORHOOD 5761 03:32:29,060 --> 03:32:29,827 STRESSORS, CULTURAL NORMS, JUST 5762 03:32:29,827 --> 03:32:32,697 TO NAME A FEW. 5763 03:32:32,697 --> 03:32:33,464 AND DESPITE CONTINUING 5764 03:32:33,464 --> 03:32:35,233 ADVANCEMENTS IN UNDERSTANDING OF 5765 03:32:35,233 --> 03:32:37,201 SUBSTANCE USE IN YOUTH THERE'S 5766 03:32:37,201 --> 03:32:40,605 STILL IMPORTANT LIMITATIONS TO 5767 03:32:40,605 --> 03:32:41,572 ADDRESS. 5768 03:32:41,572 --> 03:32:42,340 GENETIC STUDIES LACK 5769 03:32:42,340 --> 03:32:44,208 GENERALIZABILITY GO DUE TO FOCUS 5770 03:32:44,208 --> 03:32:45,877 ON PARTICIPANTS OF EUROPEAN 5771 03:32:45,877 --> 03:32:47,945 ANCESTRY, AND TO DATE SEVERAL 5772 03:32:47,945 --> 03:32:49,914 GENETIC STUDIES OFTEN FOCUS ON 5773 03:32:49,914 --> 03:32:51,649 MORE PROBLEMATIC DRUG USE 5774 03:32:51,649 --> 03:32:52,984 PATTERNS. 5775 03:32:52,984 --> 03:32:54,886 THEREFORE THEY ARE NOT AS 5776 03:32:54,886 --> 03:32:56,154 GENERALIZABLE TO LOW AND 5777 03:32:56,154 --> 03:33:02,260 EXPERIMENTATION TYPE OF USE 5778 03:33:02,260 --> 03:33:10,468 THAT MIMIC YOUTH FIRST ONSET OF 5779 03:33:10,468 --> 03:33:12,537 SUBSTANCE USE, LIMITING 5780 03:33:12,537 --> 03:33:13,738 EXPLORATION OF UNDERSTUDIED 5781 03:33:13,738 --> 03:33:16,274 FACTORS, AND LASTLY USING COMMON 5782 03:33:16,274 --> 03:33:18,209 ANALYTICAL APPROACHES THE 5783 03:33:18,209 --> 03:33:19,343 CO-OCCURRING AND INTERACTIVE 5784 03:33:19,343 --> 03:33:22,280 EFFECT OF ENVIRONMENTAL FEATURES 5785 03:33:22,280 --> 03:33:23,147 ARE OFTEN OVERLOOKED. 5786 03:33:23,147 --> 03:33:25,349 SO NOW WE'RE GOING TO EXPLORE 5787 03:33:25,349 --> 03:33:27,218 SOME POTENTIAL SOLUTIONS TO 5788 03:33:27,218 --> 03:33:29,287 ADDRESS LIMITATION WITHIN THE 5789 03:33:29,287 --> 03:33:29,687 FIELD. 5790 03:33:29,687 --> 03:33:32,690 IT'S CRITICAL WE USE DATA DRIVEN 5791 03:33:32,690 --> 03:33:33,658 STRATEGIES TO EXPLORE TOTALITY 5792 03:33:33,658 --> 03:33:37,729 OF THE ENVIRONMENT AND THIS IS 5793 03:33:37,729 --> 03:33:39,263 DEFINED AS EXPOSOME, INCLUDING 5794 03:33:39,263 --> 03:33:41,566 ALL NON-GENETIC FACTORS THAT MAY 5795 03:33:41,566 --> 03:33:44,502 BE INFLUENCING ADOLESCENT HEALTH 5796 03:33:44,502 --> 03:33:45,503 OUTCOMES. 5797 03:33:45,503 --> 03:33:47,472 AND MUCH LIKE STUDYING GENOME 5798 03:33:47,472 --> 03:33:50,208 UTILIZING THIS DISCOVERY BASED 5799 03:33:50,208 --> 03:33:51,943 APPROACHES LIKE THE 5800 03:33:51,943 --> 03:33:54,679 EXPOSOME-WIDE ASSOCIATION STUDY 5801 03:33:54,679 --> 03:33:57,749 ALLOWS FOR SYSTEMATICALLY 5802 03:33:57,749 --> 03:33:58,750 ASSOCIATED MULTIPLE NON-GENETIC 5803 03:33:58,750 --> 03:33:59,484 EXPOSURE TO WHATEVER PHENOTYPE 5804 03:33:59,484 --> 03:34:03,554 OF HAVE YOU MAY D. - - THEREOF 5805 03:34:03,554 --> 03:34:06,491 YOU MAY BE INTERESTED IN. 5806 03:34:06,491 --> 03:34:09,260 WE CAN ADDRESS LIMITATION OF 5807 03:34:09,260 --> 03:34:12,196 ONLY EXPLORING THESE EFFECTS OF 5808 03:34:12,196 --> 03:34:13,164 INDIVIDUAL EXPOSURES BY 5809 03:34:13,164 --> 03:34:13,831 COMPUTING NON-GENETIC RISK 5810 03:34:13,831 --> 03:34:18,002 SCORES WHICH GIVE A SINGLE 5811 03:34:18,002 --> 03:34:20,138 PREDICTIVE INDEX, ALLOWING YOU 5812 03:34:20,138 --> 03:34:23,341 TOES CAPTURE CONTRIBUTION OF 5813 03:34:23,341 --> 03:34:25,343 MULTIPLE EXPOSOMIC VARIABLES. 5814 03:34:25,343 --> 03:34:26,978 AND THIS IS RELATIVELY NEW 5815 03:34:26,978 --> 03:34:29,180 STUDIES USING THIS APPROACH 5816 03:34:29,180 --> 03:34:32,450 FOUND THAT IT IMPROVED 5817 03:34:32,450 --> 03:34:34,085 PREDICTIVE ACCURACY OF TYPE 2 5818 03:34:34,085 --> 03:34:37,588 DIABETES BY THREE-FOLD COMPARED 5819 03:34:37,588 --> 03:34:42,727 TO POLY POLYGENIC RISK SCORES. 5820 03:34:42,727 --> 03:34:45,897 THE GOAL OF MY WORK IS TO 5821 03:34:45,897 --> 03:34:48,432 IMPLEMENT NOVEL APPROACHES IN 5822 03:34:48,432 --> 03:34:50,134 ABCD STUDY TO ROBUSTLY 5823 03:34:50,134 --> 03:34:51,035 CHARACTERIZE ENVIRONMENT OF 5824 03:34:51,035 --> 03:34:53,471 FIRST USE AND DEVELOP WHAT WE'RE 5825 03:34:53,471 --> 03:34:55,673 CALLING POLY EXPOSURE RISK 5826 03:34:55,673 --> 03:34:56,207 SCORES. 5827 03:34:56,207 --> 03:34:58,943 SO THERE ARE TWO MAIN AIMS OF MY 5828 03:34:58,943 --> 03:35:02,013 WORK, ONE TO CONDUCT 5829 03:35:02,013 --> 03:35:03,881 EXPOSOME-WIDE ASSOCIATION STUDY 5830 03:35:03,881 --> 03:35:04,982 TO EVALUATE EXPOSOMIC 5831 03:35:04,982 --> 03:35:06,751 ASSOCIATIONS WITH SUBSTANCE USE 5832 03:35:06,751 --> 03:35:08,352 ONSET IN YOUTH. 5833 03:35:08,352 --> 03:35:10,922 AND AIM TWO, DERIVE POLY 5834 03:35:10,922 --> 03:35:13,324 EXPOSURE RISK SCORES TO ASSESS 5835 03:35:13,324 --> 03:35:16,494 ADDITIVE AND CUMULATIVE RISK ON 5836 03:35:16,494 --> 03:35:17,361 SUBSTANCE USE ONSET. 5837 03:35:17,361 --> 03:35:20,431 SO NOW I'M GOING TO GIVE YOU A 5838 03:35:20,431 --> 03:35:23,067 WALK-THROUGH OF THE STUDY DESIGN 5839 03:35:23,067 --> 03:35:26,103 WORK FLOW. 5840 03:35:26,103 --> 03:35:29,941 FIRST I STARTED CLASSIFYING TIME 5841 03:35:29,941 --> 03:35:32,343 TO SUBSTANCE USE ONSET IN THE 5842 03:35:32,343 --> 03:35:33,010 COHORT. 5843 03:35:33,010 --> 03:35:35,746 WE INCLUDED LEGAL SUBSTANCES SO 5844 03:35:35,746 --> 03:35:37,481 THIS SPECIFICALLY INCLUDED 5845 03:35:37,481 --> 03:35:42,720 DIFFERENT TYPES OF NICOTINE AND 5846 03:35:42,720 --> 03:35:43,921 TOBACCO, WHETHER THEY VAPE, 5847 03:35:43,921 --> 03:35:46,891 DIFFERENT TYPES OF CANNABIS, 5848 03:35:46,891 --> 03:35:49,193 EDIBLES, BLUNT, AND ALCOHOL. 5849 03:35:49,193 --> 03:35:50,728 FOR EACH DRUG, QUESTIONS FOR 5850 03:35:50,728 --> 03:35:53,798 EACH DRUG WERE ASKED SEPARATELY. 5851 03:35:53,798 --> 03:35:55,233 AND JUST GENERAL UNDERSTANDING 5852 03:35:55,233 --> 03:35:57,068 WHAT THE QUESTION ASKED WAS HAVE 5853 03:35:57,068 --> 03:35:59,036 YOU HAD A FULL DOSE OF THIS DRUG 5854 03:35:59,036 --> 03:36:02,440 OR HAVE YOU HAD A FULL DRINK OF 5855 03:36:02,440 --> 03:36:03,541 ALCOHOL, AND THAT QUESTION WAS 5856 03:36:03,541 --> 03:36:07,211 FOLLOWED BY WHEN WAS YOUR FIRST 5857 03:36:07,211 --> 03:36:08,012 USE. 5858 03:36:08,012 --> 03:36:09,714 SO FOR PARTICIPANTS WHO ENDORSED 5859 03:36:09,714 --> 03:36:13,684 YES TO HAVING A FULL DRUG, 5860 03:36:13,684 --> 03:36:15,786 SORRY, YES, SO FOR PARTICIPANTS 5861 03:36:15,786 --> 03:36:17,188 WHO ENDORSED HAVING YES TO 5862 03:36:17,188 --> 03:36:19,056 HAVING A FULL DRUG THERE WERE 5863 03:36:19,056 --> 03:36:20,691 SEVERAL PARTICIPANTS WHO 5864 03:36:20,691 --> 03:36:21,692 ENDORSED YES TO MULTIPLE 5865 03:36:21,692 --> 03:36:22,793 DIFFERENT DRUGS. 5866 03:36:22,793 --> 03:36:24,996 BUT IN THIS CASE WE'RE ONLY 5867 03:36:24,996 --> 03:36:26,530 INTERESTED IN TIME TO SUBSTANCE 5868 03:36:26,530 --> 03:36:28,499 USE ONSET SO WE ONLY TOOK THE 5869 03:36:28,499 --> 03:36:30,368 FIRST DRUG THAT THEY ENDORSED 5870 03:36:30,368 --> 03:36:31,769 YES TO. 5871 03:36:31,769 --> 03:36:34,171 FOR SOME PARTICIPANTS THEY 5872 03:36:34,171 --> 03:36:36,007 PROVIDED THEIR AGE OF FIRST-TIME 5873 03:36:36,007 --> 03:36:37,475 OF ONSET, FOR PARTICIPANTS WHO 5874 03:36:37,475 --> 03:36:39,110 DID NOT PROVIDE THEIR AGE WE 5875 03:36:39,110 --> 03:36:41,412 USED WHAT'S CALLED A TIME TO 5876 03:36:41,412 --> 03:36:43,814 EVENT ANALYSIS, AND WITHIN THIS 5877 03:36:43,814 --> 03:36:45,449 ANALYSIS WE USED THEIR AGE OF 5878 03:36:45,449 --> 03:36:48,252 THE LAST -- AGE THEY ENDORSED 5879 03:36:48,252 --> 03:36:50,254 YES, AT FIRST INTERVIEW DATE. 5880 03:36:50,254 --> 03:36:52,790 FOR EXAMPLE, IF A PARTICIPANT 5881 03:36:52,790 --> 03:36:55,126 SAID YES TO HAVING ALCOHOL AT 5882 03:36:55,126 --> 03:36:56,661 YEAR ONE, AND ALSO SAID YES AT 5883 03:36:56,661 --> 03:36:59,230 YEAR TWO, WE TOOK THEIR AGE AT 5884 03:36:59,230 --> 03:36:59,931 YEAR ONE. 5885 03:36:59,931 --> 03:37:02,233 AT YEAR ONE THOSE PARTICIPANTS 5886 03:37:02,233 --> 03:37:04,869 WERE ABOUT 10 TO 11 YEARS OLD. 5887 03:37:04,869 --> 03:37:08,005 AND THEN FOR PARTICIPANTS WHO 5888 03:37:08,005 --> 03:37:09,974 ENDORSED NO TO HAVING NONE OF 5889 03:37:09,974 --> 03:37:13,277 THE DRUGS WE ALSO USED THE 5890 03:37:13,277 --> 03:37:15,680 SIMILAR TECHNIQUE BUT TOOK THE 5891 03:37:15,680 --> 03:37:18,983 AGE AT THEIR LAST WAVE OF DATA 5892 03:37:18,983 --> 03:37:19,417 COLLECTION. 5893 03:37:19,417 --> 03:37:21,819 SO IF A PARTICIPANT ENDORSED NO 5894 03:37:21,819 --> 03:37:24,989 AT YEAR FOUR, WE TOOK THEIR YEAR 5895 03:37:24,989 --> 03:37:25,323 FOUR AGE. 5896 03:37:25,323 --> 03:37:27,525 AND TO CLARIFY WITHIN THIS 5897 03:37:27,525 --> 03:37:29,660 POPULATION I LOOKED AT ALL OF 5898 03:37:29,660 --> 03:37:32,596 THE AVAILABLE SUBSTANCE USE 5899 03:37:32,596 --> 03:37:34,665 DATA, AT THE CURRENT TIME SO 5900 03:37:34,665 --> 03:37:39,036 THAT TAKES US UP TO YEAR FOUR. 5901 03:37:39,036 --> 03:37:43,641 THE TIME TO SUBSTANCE USE ONSET 5902 03:37:43,641 --> 03:37:44,842 RANGED FROM APPROXIMATELY AGE 4 5903 03:37:44,842 --> 03:37:48,112 TO 15 YEARS OLD, AND THE EARLIER 5904 03:37:48,112 --> 03:37:50,982 AGES THAT WE'RE SEEING WERE 5905 03:37:50,982 --> 03:37:53,050 BASED ON PARTICIPANT 5906 03:37:53,050 --> 03:37:54,485 SELF-REPORT. 5907 03:37:54,485 --> 03:37:56,454 SO FOLLOWING THE SUBSTANCE 5908 03:37:56,454 --> 03:37:58,322 USE -- FOLLOWING PUTTING 5909 03:37:58,322 --> 03:37:59,323 TOGETHER SUBSTANCE USE 5910 03:37:59,323 --> 03:38:01,959 POPULATION, I WENT THROUGH ABCD 5911 03:38:01,959 --> 03:38:04,128 DATA TO IDENTIFY EXPOSOMIC RISK 5912 03:38:04,128 --> 03:38:04,362 FACTORS. 5913 03:38:04,362 --> 03:38:06,530 SO BECAUSE THIS WAS DATA-DRIVEN 5914 03:38:06,530 --> 03:38:09,467 APPROACH WE WANTED TO INCLUDE 5915 03:38:09,467 --> 03:38:12,436 ALL POSSIBLE NON-GENETIC 5916 03:38:12,436 --> 03:38:13,004 FACTORS. 5917 03:38:13,004 --> 03:38:17,675 SO WE CHARACTERIZED GROUPS INTO 5918 03:38:17,675 --> 03:38:19,010 LIFESTYLE, HOME, PARENTAL 5919 03:38:19,010 --> 03:38:20,411 HEALTH, CULTURE, NEIGHBORHOOD, 5920 03:38:20,411 --> 03:38:22,513 AND SCHOOL. 5921 03:38:22,513 --> 03:38:24,715 AND WITHIN OUR LIFESTYLE DOMAIN 5922 03:38:24,715 --> 03:38:26,350 LOOKED AT VARIABLES RELATED TO 5923 03:38:26,350 --> 03:38:29,387 SCREEN MEDIA EXPOSURE AS WELL AS 5924 03:38:29,387 --> 03:38:30,388 THE NUMBER OF SPORT ACTIVITIES 5925 03:38:30,388 --> 03:38:31,822 THEY WERE INVOLVED IN, I 5926 03:38:31,822 --> 03:38:33,224 REMEMBER SOMEONE ASKED THE 5927 03:38:33,224 --> 03:38:34,959 QUESTION REGARDING THAT. 5928 03:38:34,959 --> 03:38:36,394 AND HOW MUCH SLEEP -- WHETHER 5929 03:38:36,394 --> 03:38:43,067 THEY HAD ANY SLEEP DISORDERS OR 5930 03:38:43,067 --> 03:38:45,503 SLEEP THE PATTERNS AND LOOKED AT 5931 03:38:45,503 --> 03:38:47,204 PARENTAL MONITORING IN THE HOME. 5932 03:38:47,204 --> 03:38:48,439 THE WAY PARENTS TREATED THEM 5933 03:38:48,439 --> 03:38:49,740 WITHIN THE HOME. 5934 03:38:49,740 --> 03:38:52,143 WHETHER THEY HAD FAMILY 5935 03:38:52,143 --> 03:38:54,311 CONFLICT, ADVERSE CHILD EVENTS. 5936 03:38:54,311 --> 03:38:54,979 WITHIN THE PARENTAL HEALTH 5937 03:38:54,979 --> 03:38:58,482 DOMAIN WE LOOKED AT WHETHER THE 5938 03:38:58,482 --> 03:39:00,785 PARENTS HAD ANY HISTORY OF 5939 03:39:00,785 --> 03:39:02,953 PSYCHOPATHOLOGY, IN ABCD THERE'S 5940 03:39:02,953 --> 03:39:05,489 ADULT SELF-REPORT WHICH LOOKS AT 5941 03:39:05,489 --> 03:39:06,590 PARENTAL PSYCHOPATHOLOGY SO 5942 03:39:06,590 --> 03:39:08,225 THERE WAS THAT INCLUSION, ALSO 5943 03:39:08,225 --> 03:39:14,065 IF THE PARENTS HAD HISTORY OF 5944 03:39:14,065 --> 03:39:15,232 PSYCHOLOGICAL PROBLEMS. 5945 03:39:15,232 --> 03:39:17,835 WITHIN THE CULTURE DOMAIN WE 5946 03:39:17,835 --> 03:39:22,573 LOOKED AT TWO -- THERE WERE TWO 5947 03:39:22,573 --> 03:39:23,207 SPECIFIC QUESTIONNAIRES WITHIN 5948 03:39:23,207 --> 03:39:26,077 ABCD THAT FELL INTO THIS 5949 03:39:26,077 --> 03:39:26,343 CATEGORY. 5950 03:39:26,343 --> 03:39:28,579 THAT WAS THE MEXICAN AMERICAN 5951 03:39:28,579 --> 03:39:30,114 CULTURAL VALUE SUBSCALE WHICH 5952 03:39:30,114 --> 03:39:32,550 LOOKED AT DIFFERENT ASPECTS OF 5953 03:39:32,550 --> 03:39:33,951 THE FAMILY ENVIRONMENT. 5954 03:39:33,951 --> 03:39:35,686 SO THAT ALSO INCLUDED THEIR 5955 03:39:35,686 --> 03:39:37,021 RELIGIOUS BELIEFS, HOW CLOSE 5956 03:39:37,021 --> 03:39:41,292 THEY WERE TO THEIR FAMILY. 5957 03:39:41,292 --> 03:39:42,326 AND ALSO THEIR CULTURAL 5958 03:39:42,326 --> 03:39:42,927 IDENTITY. 5959 03:39:42,927 --> 03:39:44,895 IN THE NEIGHBORHOOD DOMAIN ABCD 5960 03:39:44,895 --> 03:39:47,965 DOES A WONDERFUL JOB COLLECTING 5961 03:39:47,965 --> 03:39:50,267 SELF-REPORT MEASURES BUT ALSO 5962 03:39:50,267 --> 03:39:53,204 GEO CODED MEASURES, AND THESE 5963 03:39:53,204 --> 03:39:56,173 MEASURES ARE DERIVED BASED ON 5964 03:39:56,173 --> 03:39:56,707 PARTICIPANTS' RESIDENTIAL 5965 03:39:56,707 --> 03:39:58,242 ADDRESS, WE ALSO TOOK A LOOK AT 5966 03:39:58,242 --> 03:40:00,344 SOME OF THOSE MEASURES AND THEN 5967 03:40:00,344 --> 03:40:02,079 WITHIN THE SCHOOL DOMAINS THERE 5968 03:40:02,079 --> 03:40:05,716 WAS ONE QUESTIONNAIRE THAT HAD 5969 03:40:05,716 --> 03:40:07,985 AVAILABLE DATA FOR -- AT 5970 03:40:07,985 --> 03:40:09,854 BASELINE, AND THIS QUESTIONNAIRE 5971 03:40:09,854 --> 03:40:12,356 LOOKED AT SCHOOL ENGAGEMENT, 5972 03:40:12,356 --> 03:40:15,793 SCHOOL DISENGAGEMENT, SCHOOL 5973 03:40:15,793 --> 03:40:17,628 ENVIRONMENT, AND SCHOOL 5974 03:40:17,628 --> 03:40:17,928 INVOLVEMENT. 5975 03:40:17,928 --> 03:40:19,597 AND THEN FOLLOWING THE 5976 03:40:19,597 --> 03:40:21,132 IDENTIFICATION OF OUR EXPOSOME 5977 03:40:21,132 --> 03:40:24,768 AND SUBSTANCE USE ONSET GROUP WE 5978 03:40:24,768 --> 03:40:29,039 THEN WENT INTO OUR ANALYSES. 5979 03:40:29,039 --> 03:40:32,643 FOR THESE I CONDUCT -- WHAT I 5980 03:40:32,643 --> 03:40:36,113 REFERRED TO BEFORE, WHAT THIS 5981 03:40:36,113 --> 03:40:38,115 IS, THESE ARE UNIVARIATE 5982 03:40:38,115 --> 03:40:38,983 ANALYSIS, SINGLE EXPOSURE 5983 03:40:38,983 --> 03:40:39,250 ANALYSES. 5984 03:40:39,250 --> 03:40:41,585 INSTEAD OF LOOKING AT ALL OF THE 5985 03:40:41,585 --> 03:40:43,254 VARIABLES SIMULTANEOUSLY IN ONE 5986 03:40:43,254 --> 03:40:46,991 MODEL WE FIRST START BY LOOKING 5987 03:40:46,991 --> 03:40:50,594 AT ONE SINGLE EXPOSURE, 5988 03:40:50,594 --> 03:40:51,562 ASSOCIATED TO SUBSTANCE USE 5989 03:40:51,562 --> 03:40:51,929 OUTCOME. 5990 03:40:51,929 --> 03:40:53,364 WITHIN THIS MODEL BECAUSE WE'RE 5991 03:40:53,364 --> 03:40:55,966 LOOKING AT TIME TO SUBSTANCE USE 5992 03:40:55,966 --> 03:40:58,602 ONSET WE'RE USING WHAT'S CALLED 5993 03:40:58,602 --> 03:40:59,136 SURVIVAL ANALYSIS, COST 5994 03:40:59,136 --> 03:41:02,406 REGRESSION, AND WITHIN THAT 5995 03:41:02,406 --> 03:41:04,308 MODEL WE CONTROLLED FOR SEX, 5996 03:41:04,308 --> 03:41:06,377 SOME MODELS WE RAN THESE A 5997 03:41:06,377 --> 03:41:08,245 COUPLE TIMES, SOME OF THOSE WE 5998 03:41:08,245 --> 03:41:12,950 RAN CONTROLLING FOR RACE 5999 03:41:12,950 --> 03:41:15,686 ETHNICITY BUT WHAT I'M SHOWING 6000 03:41:15,686 --> 03:41:20,157 TODAY WE CONTROLLED FOR PUBERTY 6001 03:41:20,157 --> 03:41:21,892 SCORE AND FAMILY ID SINCE THERE 6002 03:41:21,892 --> 03:41:25,196 ARE FAMILIES WITHIN THE ABCD 6003 03:41:25,196 --> 03:41:28,933 STUDY AS WELL. 6004 03:41:28,933 --> 03:41:30,134 FOLLOWING THE IDENTIFICATION -- 6005 03:41:30,134 --> 03:41:34,939 SORRY, TO GO BACK WE THEN NOT 6006 03:41:34,939 --> 03:41:36,340 CONTROLLED, SORRY, CORRECTED FOR 6007 03:41:36,340 --> 03:41:37,908 MULTIPLE COMPARISONS. 6008 03:41:37,908 --> 03:41:41,378 AND THEN FOLLOWING THAT WE THEN 6009 03:41:41,378 --> 03:41:43,681 APPLIED A MULTIVARIATE MODEL, 6010 03:41:43,681 --> 03:41:46,750 WANTED TO IDENTIFY MOST 6011 03:41:46,750 --> 03:41:47,718 INDEPENDENT ASSOCIATIONS SO 6012 03:41:47,718 --> 03:41:49,386 SIGNIFICANT VARIABLES FROM OUR 6013 03:41:49,386 --> 03:41:51,689 FIRST MODEL WE BUILT A 6014 03:41:51,689 --> 03:41:53,757 MULTIVARIATE MODEL AND FOLLOWING 6015 03:41:53,757 --> 03:41:56,093 THAT THE FINAL SIGNIFICANT 6016 03:41:56,093 --> 03:41:59,029 VARIABLES WERE USED TO BUILD OUR 6017 03:41:59,029 --> 03:42:01,899 POLY EXPOSURE RISK SCORE. 6018 03:42:01,899 --> 03:42:04,501 AND THIS SCORE IS A WEIGHTED SUM 6019 03:42:04,501 --> 03:42:08,239 OF ALL OF THE ESTIMATES OF THE 6020 03:42:08,239 --> 03:42:11,976 VARIABLES THAT SIGNIFICANT 6021 03:42:11,976 --> 03:42:13,177 WITHIN OUR FINAL MODEL. 6022 03:42:13,177 --> 03:42:14,845 NOW I'LL GO INTO RESULTS FROM 6023 03:42:14,845 --> 03:42:15,913 OUR AIM ONE. 6024 03:42:15,913 --> 03:42:21,418 SO I FORGOT TO MENTION WE 6025 03:42:21,418 --> 03:42:24,788 IDENTIFIED 200 QUALITY 6026 03:42:24,788 --> 03:42:25,422 CONTROLLED EXPOSOMIC VARIABLES, 6027 03:42:25,422 --> 03:42:26,957 ABCD HAS MANY MORE BUT THESE 6028 03:42:26,957 --> 03:42:30,361 WERE THE ONCE WE QUALITY 6029 03:42:30,361 --> 03:42:30,661 CONTROLLED. 6030 03:42:30,661 --> 03:42:34,632 AND AMONG THOSE 200 WE 6031 03:42:34,632 --> 03:42:37,134 IDENTIFIED 74 EXPOSOMIC FEATURES 6032 03:42:37,134 --> 03:42:37,901 THAT WERE INDEPENDENTLY 6033 03:42:37,901 --> 03:42:40,437 ASSOCIATED WITH TIME TO 6034 03:42:40,437 --> 03:42:41,505 SUBSTANCE USE ONSET. 6035 03:42:41,505 --> 03:42:44,508 SO THE FOLLOWING MANHATTAN PLOT 6036 03:42:44,508 --> 03:42:45,809 SHOWS SIGNIFICANT VARIABLES 6037 03:42:45,809 --> 03:42:47,378 IDENTIFIED IN OUR ANALYSES, AND 6038 03:42:47,378 --> 03:42:49,413 I ONLY LABELED A FEW OF THEM 6039 03:42:49,413 --> 03:42:51,282 SINCE THEY WERE QUITE A LOT AND 6040 03:42:51,282 --> 03:42:55,252 I DIDN'T WANT TO MAKE THE SLIDES 6041 03:42:55,252 --> 03:42:56,654 TOO CONFUSING. 6042 03:42:56,654 --> 03:42:59,156 AND THEN AMONG THOSE 74 6043 03:42:59,156 --> 03:43:00,824 VARIABLES, WE SAW THEY 6044 03:43:00,824 --> 03:43:02,226 REPRESENTED BOTH PROTECTIVE AND 6045 03:43:02,226 --> 03:43:05,095 RISK FACTORS FOR SUBSTANCE USE 6046 03:43:05,095 --> 03:43:05,629 ONSET. 6047 03:43:05,629 --> 03:43:07,598 AND MORE CLOSELY, SOME OF THE 6048 03:43:07,598 --> 03:43:08,465 INTERESTING RESULTS THAT WE 6049 03:43:08,465 --> 03:43:10,434 FOUND I DIDN'T GET A CHANCE TO 6050 03:43:10,434 --> 03:43:13,704 HIGHLIGHT THEM BUT WHAT WE FOUND 6051 03:43:13,704 --> 03:43:17,007 WAS THAT DIFFERENT TYPES OF 6052 03:43:17,007 --> 03:43:17,775 EXPERIENCE OF THIS 6053 03:43:17,775 --> 03:43:19,243 DISCRIMINATION, R RATED MOVIE 6054 03:43:19,243 --> 03:43:23,580 AND R RATED VIDEO GAME EXPOSURE, 6055 03:43:23,580 --> 03:43:24,982 ADVERSE HOME EXPERIENCES, 6056 03:43:24,982 --> 03:43:25,783 PRENATAL DRUG EXPOSURE BOTH 6057 03:43:25,783 --> 03:43:27,084 BEFORE PARENTS WERE AWARE THEY 6058 03:43:27,084 --> 03:43:31,455 WERE PREGNANT AND AFTER THEY 6059 03:43:31,455 --> 03:43:32,990 WERE AWARE, PARENTAL 6060 03:43:32,990 --> 03:43:33,857 PSYCHOPATHOLOGIES, ASSOCIATED 6061 03:43:33,857 --> 03:43:35,926 WITH INCREASED LIKELIHOOD OF 6062 03:43:35,926 --> 03:43:38,228 SUBSTANCE USE ONSET. 6063 03:43:38,228 --> 03:43:40,864 AND ALSO ONE THAT I FORGOT TO 6064 03:43:40,864 --> 03:43:42,066 MENTION BUT WE ALSO SAW KIDS 6065 03:43:42,066 --> 03:43:44,234 THAT CAME FROM HOMES WHERE THEY 6066 03:43:44,234 --> 03:43:47,538 HAD NO RULES REGARDING CANNABIS 6067 03:43:47,538 --> 03:43:49,707 USE WAS ALSO SIGNIFICANT. 6068 03:43:49,707 --> 03:43:51,041 WAS ALSO SIGNIFICANTLY 6069 03:43:51,041 --> 03:43:52,810 ASSOCIATED WITH INCREASED RISK 6070 03:43:52,810 --> 03:43:55,079 FOR SUBSTANCE USE ONSET. 6071 03:43:55,079 --> 03:43:57,381 AND WITHIN OUR PROTECTIVE 6072 03:43:57,381 --> 03:44:01,251 FACTORS WHICH YOU SEE AT THE 6073 03:44:01,251 --> 03:44:02,353 BOTTOM HERE WE SAW THAT -- I'M 6074 03:44:02,353 --> 03:44:04,655 GOING TO TAKE A STEP BACK. 6075 03:44:04,655 --> 03:44:06,623 AMONG RISK FACTORS WE IDENTIFIED 6076 03:44:06,623 --> 03:44:09,993 TWO OF THE GEO CODED MEASURES 6077 03:44:09,993 --> 03:44:11,261 THAT WERE SIGNIFICANTLY 6078 03:44:11,261 --> 03:44:18,168 ASSOCIATED WITH INCREASED RISK 6079 03:44:18,168 --> 03:44:21,271 AND THOSE TWO FACTORS WERE 6080 03:44:21,271 --> 03:44:24,007 PERCENT OF POPULATION THAT WAS 6081 03:44:24,007 --> 03:44:28,145 BELOW POVERTY LEVEL AND FROM THE 6082 03:44:28,145 --> 03:44:28,679 AREA DEPRIVATION INDEX 6083 03:44:28,679 --> 03:44:30,214 IDENTIFIED PERCENT OF THE 6084 03:44:30,214 --> 03:44:31,749 POPULATION THAT HAD NO 6085 03:44:31,749 --> 03:44:32,216 TELEPHONE. 6086 03:44:32,216 --> 03:44:34,785 SO EVEN THOUGH WE HAVE NOT MADE 6087 03:44:34,785 --> 03:44:36,453 ASSUMPTION OF WHAT THESE 6088 03:44:36,453 --> 03:44:37,988 VARIABLES MEAN, IT'S INTERESTING 6089 03:44:37,988 --> 03:44:40,124 THAT WE'RE SEEING SOME VARIABLES 6090 03:44:40,124 --> 03:44:42,059 THAT DOES SHOW UP IN OTHER 6091 03:44:42,059 --> 03:44:44,895 STUDIES AND THESE ADDITIONAL 6092 03:44:44,895 --> 03:44:46,730 UNIQUE VARIABLES FROM THE 6093 03:44:46,730 --> 03:44:47,131 GEOCODED MEASURES. 6094 03:44:47,131 --> 03:44:50,234 I'M GOING TO DISCUSS OUR 6095 03:44:50,234 --> 03:44:51,001 PROTECTIVE FACTORS. 6096 03:44:51,001 --> 03:44:56,273 FOR PROTECTIVE FACTORS WE'RE 6097 03:44:56,273 --> 03:45:01,845 SEEING PROSOCIAL BEHAVIORS, 6098 03:45:01,845 --> 03:45:04,481 BETTER SCHOOL ENVIRONMENT, MORE 6099 03:45:04,481 --> 03:45:05,449 PARENTAL MONITORING, YOUTH WHO 6100 03:45:05,449 --> 03:45:06,650 SAW RELIGIOUS BELIEFS WERE VERY 6101 03:45:06,650 --> 03:45:09,286 IMPORTANT AS WELL AS HIGHER 6102 03:45:09,286 --> 03:45:10,587 SOCIOECONOMIC INDICES WERE 6103 03:45:10,587 --> 03:45:15,859 ASSOCIATED WITH DECREASED RISK 6104 03:45:15,859 --> 03:45:18,362 OF SUBSTANCE USE ONSET. 6105 03:45:18,362 --> 03:45:19,663 FOLLOWING IDENTIFICATION OF THE 6106 03:45:19,663 --> 03:45:21,865 SIGNIFICANT VARIABLES AS I 6107 03:45:21,865 --> 03:45:23,600 MENTIONED BEFORE WE BUILD 6108 03:45:23,600 --> 03:45:26,003 MULTI-VARIATE MODEL AND FINAL 6109 03:45:26,003 --> 03:45:31,074 RISK SCORE INCLUDED VARIABLES 6110 03:45:31,074 --> 03:45:37,481 SIGNIFICANT FROM THAT MODEL PXS 6111 03:45:37,481 --> 03:45:39,349 SCORES FROM LIFESTYLE, HOME, 6112 03:45:39,349 --> 03:45:40,117 NEIGHBORHOOD DOMAINS. 6113 03:45:40,117 --> 03:45:43,620 WE SAW THAT ALL TYPES OF R-RATED 6114 03:45:43,620 --> 03:45:47,257 MOVIE EXPOSURE, YOUTH WHO HAD NO 6115 03:45:47,257 --> 03:45:49,526 CANNABIS USE RULES, PRENATAL 6116 03:45:49,526 --> 03:45:52,362 CANNABIS EXPOSURE AND PRENATAL 6117 03:45:52,362 --> 03:45:53,564 TOBACCO EXPOSURE AND GEO CODED 6118 03:45:53,564 --> 03:45:55,232 MEASURES PERCENTAGE OF 6119 03:45:55,232 --> 03:45:57,835 POPULATION BELOW POVERTY AND 6120 03:45:57,835 --> 03:46:00,270 PERCENTAGE OF HOUSEHOLDS WITHOUT 6121 03:46:00,270 --> 03:46:02,873 TELEPHONE WERE RETAINED IN OUR 6122 03:46:02,873 --> 03:46:04,842 FINAL POLY EXPOSURE SCORE. 6123 03:46:04,842 --> 03:46:06,610 AND THEN WE COMPARED TO SEE 6124 03:46:06,610 --> 03:46:08,479 WHETHER SCORES WERE DIFFERENT 6125 03:46:08,479 --> 03:46:10,647 FOR SUBSTANCE USE NAIVE AND 6126 03:46:10,647 --> 03:46:14,051 SUBSTANCE USE EXPOSED. 6127 03:46:14,051 --> 03:46:16,320 AND WE SAW THAT THERE WERE 6128 03:46:16,320 --> 03:46:19,523 SIGNIFICANTLY HIGHER IN OUR 6129 03:46:19,523 --> 03:46:20,824 ALCOHOL-EXPOSED -- IN OUR 6130 03:46:20,824 --> 03:46:22,125 SUBSTANCE-EXPOSED GROUP WHICH IS 6131 03:46:22,125 --> 03:46:23,460 THE RED LINE. 6132 03:46:23,460 --> 03:46:26,597 AND WHEN WE LOOK AT PREDICTIVE 6133 03:46:26,597 --> 03:46:29,132 POWER WITH ADDITION OF THESE 6134 03:46:29,132 --> 03:46:31,268 EXPOSOMIC VARIABLES, WE ACTUALLY 6135 03:46:31,268 --> 03:46:35,272 SAW THERE WAS A 3% INCREASE IN 6136 03:46:35,272 --> 03:46:37,140 OUR PREDICTION ACCURACY. 6137 03:46:37,140 --> 03:46:41,411 SO, IT'S NOT SUPER DUPER HIGH. 6138 03:46:41,411 --> 03:46:43,347 HOWEVER, WITH THE FURTHER 6139 03:46:43,347 --> 03:46:45,983 PREDICTIVE ACCURACY BECAUSE IT'S 6140 03:46:45,983 --> 03:46:47,851 ABOVE .5 AND IT'S PRETTY CLOSE 6141 03:46:47,851 --> 03:46:51,455 TO 1, WE CAN ASSUME THAT THESE 6142 03:46:51,455 --> 03:47:00,430 FACTORS ARE INDEED INFLUENCING 6143 03:47:00,430 --> 03:47:00,864 SUBSTANCE USE ONSET. 6144 03:47:00,864 --> 03:47:02,099 THERE'S SOME LIMITATIONS TO KEEP 6145 03:47:02,099 --> 03:47:03,400 IN MIND. 6146 03:47:03,400 --> 03:47:05,802 ONE MAJOR LIMITATION IS COMMONLY 6147 03:47:05,802 --> 03:47:07,037 WITH OBSERVATIONAL STUDIES 6148 03:47:07,037 --> 03:47:09,139 THERE'S MEASUREMENT ERROR AND 6149 03:47:09,139 --> 03:47:10,607 RECALL BIAS. 6150 03:47:10,607 --> 03:47:12,576 FOR INSTANCE WE SAW FOR YOUTH 6151 03:47:12,576 --> 03:47:14,878 SOME OF THEM ENDORSED ALCOHOL 6152 03:47:14,878 --> 03:47:16,413 USE AS EARLY AS 4 YEARS OLD. 6153 03:47:16,413 --> 03:47:19,483 WE DON'T KNOW HOW TRUE THAT IS 6154 03:47:19,483 --> 03:47:21,552 BUT WE HAVE TO USE THE 6155 03:47:21,552 --> 03:47:23,887 INFORMATION AS PROVIDED. 6156 03:47:23,887 --> 03:47:26,156 ALSO ANOTHER THING, THERE MIGHT 6157 03:47:26,156 --> 03:47:31,595 BE SOME STYING IN A WHETHER -- 6158 03:47:31,595 --> 03:47:34,331 STIGMA, THERE'S AN ABCD STUDY 6159 03:47:34,331 --> 03:47:36,199 THAT LOOKED AT HAIR TOXICOLOGY, 6160 03:47:36,199 --> 03:47:39,069 AND THEY FOUND THAT MORE YOUTH 6161 03:47:39,069 --> 03:47:40,704 ACTUALLY WERE USING SUBSTANCES 6162 03:47:40,704 --> 03:47:44,007 THAN THEY ACTUALLY REPORTED. 6163 03:47:44,007 --> 03:47:49,680 THERE MAY POTENTIALLY BE AN 6164 03:47:49,680 --> 03:47:50,180 UNDERREPORTING. 6165 03:47:50,180 --> 03:47:51,882 FOR FUTURE DIRECTIONS, SIMILAR 6166 03:47:51,882 --> 03:47:53,150 TO POLYGENIC RISK SCORES 6167 03:47:53,150 --> 03:47:55,686 OFTENTIMES WHEN YOU LOOK AT 6168 03:47:55,686 --> 03:47:57,754 STUDIES WITH POLYGENIC RISK 6169 03:47:57,754 --> 03:48:00,190 SCORES THEY TEND TO STRATIFY BY 6170 03:48:00,190 --> 03:48:02,259 RISK SO THERE'S LOW RISK, 6171 03:48:02,259 --> 03:48:03,794 MEDIUM, HIGH RISK. 6172 03:48:03,794 --> 03:48:05,662 I'M INTERESTED IN DOING 6173 03:48:05,662 --> 03:48:07,731 SOMETHING SIMILAR WITH THE PXS 6174 03:48:07,731 --> 03:48:09,800 SCORES AND LOOK TOCK SEE WHETHER 6175 03:48:09,800 --> 03:48:14,071 THERE ARE ANY ASSOCIATIONS WITH 6176 03:48:14,071 --> 03:48:15,405 DIFFERENT NEUROBEHAVIORAL 6177 03:48:15,405 --> 03:48:17,574 CORRELATES FOR REWARD 6178 03:48:17,574 --> 03:48:18,475 PROCESSING, RESPONSE INHIBITION, 6179 03:48:18,475 --> 03:48:19,076 EMOTION REGULATION. 6180 03:48:19,076 --> 03:48:20,978 AND THAT'S SOMETHING THAT I'M 6181 03:48:20,978 --> 03:48:23,747 CURRENTLY WORKING ON IN MY 6182 03:48:23,747 --> 03:48:25,349 THESIS SPECIFICALLY FOR RESPONSE 6183 03:48:25,349 --> 03:48:28,418 INHIBITION, AND LASTLY I WOULD 6184 03:48:28,418 --> 03:48:30,821 LIKE TO COMPARE THESE 6185 03:48:30,821 --> 03:48:32,689 NON-GENETIC RISK SCORES TO 6186 03:48:32,689 --> 03:48:33,991 GENETIC SCORES LIKE THE 6187 03:48:33,991 --> 03:48:36,526 POLYGENIC RISK SCORE AND ALSO 6188 03:48:36,526 --> 03:48:41,565 POTENTIALLY FAMILY HISTORY OF 6189 03:48:41,565 --> 03:48:42,899 SUBSTANCE USE DENSITY. 6190 03:48:42,899 --> 03:48:44,001 THERE ARE BROADER IMPLICATIONS 6191 03:48:44,001 --> 03:48:47,704 TO KEEP IN MIND, IDENTIFICATION 6192 03:48:47,704 --> 03:48:50,240 OF EXPOSOME FACTORS ALLOW US TO 6193 03:48:50,240 --> 03:48:53,176 DO SOME WORK -- TO PUT THIS 6194 03:48:53,176 --> 03:48:54,511 INFORMATION INTO CLINICS WHERE 6195 03:48:54,511 --> 03:48:56,146 IT MAY BE MODIFIABLE. 6196 03:48:56,146 --> 03:48:57,447 THAT'S SOMETHING WE CAN CONSIDER 6197 03:48:57,447 --> 03:48:59,316 MORE IN THE FUTURE AND LIKE DR. 6198 03:48:59,316 --> 03:49:03,253 DOWLING WAS TALKING ABOUT THE 6199 03:49:03,253 --> 03:49:03,954 POLICY INTERVENTION, 6200 03:49:03,954 --> 03:49:04,821 ADDITIONALLY MORE ON TECHNICAL 6201 03:49:04,821 --> 03:49:06,690 SIDES IT WOULD BE IMPORTANT TO 6202 03:49:06,690 --> 03:49:09,660 SEE THE APPLICATION OF THIS 6203 03:49:09,660 --> 03:49:10,327 TECHNIQUE FOR DEVELOPING 6204 03:49:10,327 --> 03:49:12,162 EXPOSOME RISK SCORES FOR OTHER 6205 03:49:12,162 --> 03:49:15,232 BEHAVIORAL OUTCOMES IN THE ABCD 6206 03:49:15,232 --> 03:49:17,434 STUDY. 6207 03:49:17,434 --> 03:49:20,303 AND FINALLY I WOULD LIKE TO 6208 03:49:20,303 --> 03:49:24,441 THANK THE START COHORT. 6209 03:49:24,441 --> 03:49:27,844 DR. MICAH JOHNSON, FOR HIS BRAIN 6210 03:49:27,844 --> 03:49:28,812 CHILD BASICALLY. 6211 03:49:28,812 --> 03:49:30,580 I DON'T THINK I'D BE STANDING IN 6212 03:49:30,580 --> 03:49:34,718 THIS ROOM IF IT WERE NOT FOR THE 6213 03:49:34,718 --> 03:49:35,919 START PROGRAM. 6214 03:49:35,919 --> 03:49:38,321 AND THE START PROGRAM IS A LARGE 6215 03:49:38,321 --> 03:49:44,127 PART OF WHY I WAS FUNDED MY F31. 6216 03:49:44,127 --> 03:49:47,431 DR. GARVIN MADE IT A DUTY TO 6217 03:49:47,431 --> 03:49:49,166 CONNECT ME WITH PEOPLE WHO CAN 6218 03:49:49,166 --> 03:49:50,801 BE MENTORS AND BEFORE START I 6219 03:49:50,801 --> 03:49:54,838 HAD NOT ENVISIONED MYSELF 6220 03:49:54,838 --> 03:49:58,275 APPLYING FOR F31 WITHOUT THE 6221 03:49:58,275 --> 03:49:59,476 NETWORK AND COMMUNITY TO START 6222 03:49:59,476 --> 03:50:01,645 MY APPLICATION BUT AFTER START 6223 03:50:01,645 --> 03:50:03,780 THAT BECAME POSSIBLE. 6224 03:50:03,780 --> 03:50:07,584 DR. TRACY MURRAY HAS BEEN A 6225 03:50:07,584 --> 03:50:11,822 WONDERFUL NON-SCIENTIFIC MENTOR, 6226 03:50:11,822 --> 03:50:13,924 AND IT'S BEEN AMAZING CONNECTING 6227 03:50:13,924 --> 03:50:18,995 WITH HER, HAVING HER GUIDE ME 6228 03:50:18,995 --> 03:50:25,302 THROUGH THE NON-SCIENCE PORTION. 6229 03:50:25,302 --> 03:50:26,002 DR. WES THOMPSON WHO DEDICATED 6230 03:50:26,002 --> 03:50:27,237 SO MUCH TIME, HE DOESN'T HAVE TO 6231 03:50:27,237 --> 03:50:29,372 BUT BECAUSE OF THE START PROGRAM 6232 03:50:29,372 --> 03:50:30,907 I NOW HAVE THIS WONDERFUL 6233 03:50:30,907 --> 03:50:32,109 SUPPORT TEAM AND ONE OF THE 6234 03:50:32,109 --> 03:50:34,845 THINGS THAT THEY DID FOR THE 6235 03:50:34,845 --> 03:50:38,548 PILOT COHORT WAS THEY ACTUALLY 6236 03:50:38,548 --> 03:50:42,719 CREATED A PLAQUE WITH NAMES. 6237 03:50:42,719 --> 03:50:46,223 I WAS FINISHING UP MY SECOND 6238 03:50:46,223 --> 03:50:48,558 YEAR AND ALREADY HAD DR. FAITH 6239 03:50:48,558 --> 03:50:49,760 ADAMS ON THERE. 6240 03:50:49,760 --> 03:50:51,928 AND AT THE TIME IT WAS SO FAR 6241 03:50:51,928 --> 03:50:54,664 AWAY, NOW THAT I'M IN MY FOURTH 6242 03:50:54,664 --> 03:50:55,665 YEAR IT FINALLY FEELS REAL THAT 6243 03:50:55,665 --> 03:50:58,468 I'M GOING TO BE DR. FAITH ADAMS. 6244 03:50:58,468 --> 03:50:59,903 AND AGAIN I JUST WOULD LIKE TO 6245 03:50:59,903 --> 03:51:02,439 THANK YOU ALL FOR LISTENING. 6246 03:51:02,439 --> 03:51:03,974 THANK YOU TO NIDA FOR FUNDING 6247 03:51:03,974 --> 03:51:05,709 THIS PROGRAM. 6248 03:51:05,709 --> 03:51:07,244 THANK YOU, DR. JOHNSON, FOR 6249 03:51:07,244 --> 03:51:08,211 THINKING OF US. 6250 03:51:08,211 --> 03:51:09,980 THANK YOU, GAYA, FOR THIS 6251 03:51:09,980 --> 03:51:10,280 INVITATION. 6252 03:51:10,280 --> 03:51:14,117 THANK YOU ALL FOR LISTENING. 6253 03:51:14,117 --> 03:51:20,157 6254 03:51:20,157 --> 03:51:24,461 6255 03:51:24,461 --> 03:51:28,698 >> WE HAVE TIME FOR ONE OR TWO 6256 03:51:28,698 --> 03:51:31,868 QUESTIONS FOR FUTURE DR. FAITH 6257 03:51:31,868 --> 03:51:32,302 ADAMS. 6258 03:51:32,302 --> 03:51:32,669 >> IMPRESSIVE. 6259 03:51:32,669 --> 03:51:37,340 WHAT YOU'VE DONE WITH THE 6260 03:51:37,340 --> 03:51:39,009 EXPOSOME IS FANTASTIC. 6261 03:51:39,009 --> 03:51:40,644 NOT THAT YOU NEED ANOTHER THING 6262 03:51:40,644 --> 03:51:44,381 TO DO WHEN YOU'RE GETTING READY 6263 03:51:44,381 --> 03:51:49,052 TO GRADUATE, SOME OF THE 6264 03:51:49,052 --> 03:51:49,719 VARIABLES ARE POTENTIALLY 6265 03:51:49,719 --> 03:51:50,720 HERDABLE, SO THERE'S TWO THINGS 6266 03:51:50,720 --> 03:51:51,822 YOU COULD DO POTENTIALLY. 6267 03:51:51,822 --> 03:51:56,960 ONE WOULD BE TO LOOK AT 6268 03:51:56,960 --> 03:51:57,561 GENE/ENVIRONMENT CORRELATION, 6269 03:51:57,561 --> 03:51:58,595 ABCD IS A GREAT PLACE. 6270 03:51:58,595 --> 03:52:05,702 ER - THE OTHER TO DO POLY 6271 03:52:05,702 --> 03:52:09,973 MULTI-EXPOSOME THAT CORRELATE 6272 03:52:09,973 --> 03:52:13,176 WITH PGS, A REALLY INTERESTING 6273 03:52:13,176 --> 03:52:14,578 FINDING, PARENTAL MONITORING, 6274 03:52:14,578 --> 03:52:16,446 COMBINE GENE/ENVIRONMENT 6275 03:52:16,446 --> 03:52:17,047 CORRELATIONS AND INTERACTIONS, 6276 03:52:17,047 --> 03:52:17,747 WONDERING IF HAD YOU THOUGHTS 6277 03:52:17,747 --> 03:52:19,850 ABOUT THAT BEING A FUTURE 6278 03:52:19,850 --> 03:52:20,083 PATHWAY. 6279 03:52:20,083 --> 03:52:28,825 >> YES, THAT'S A GREAT QUESTION. 6280 03:52:28,825 --> 03:52:34,698 THERE ARE FACTORS WITH GENETIC 6281 03:52:34,698 --> 03:52:34,965 COMPONENT. 6282 03:52:34,965 --> 03:52:39,302 I HAD DECIDED TO REMOVE ACTUALLY 6283 03:52:39,302 --> 03:52:42,038 IF THEIR PARENTS REPORTED -- THE 6284 03:52:42,038 --> 03:52:43,707 QUESTION I REMOVED WAS IF 6285 03:52:43,707 --> 03:52:46,576 THEY -- FROM THE FAMILY HISTORY 6286 03:52:46,576 --> 03:52:47,978 QUESTIONNAIRE REGARDING DRUG 6287 03:52:47,978 --> 03:52:48,311 USE. 6288 03:52:48,311 --> 03:52:49,512 DRUG USE PROBLEMS AND ALCOHOL 6289 03:52:49,512 --> 03:52:50,213 USE PROBLEMS. 6290 03:52:50,213 --> 03:52:51,548 AND THE REASON FOR THAT WAS 6291 03:52:51,548 --> 03:52:54,417 BECAUSE I WANTED TO SEE IF I 6292 03:52:54,417 --> 03:52:56,286 COULD COMPARE THIS MORE GENETIC 6293 03:52:56,286 --> 03:53:00,223 FACTOR THAT STILL HAS SOME 6294 03:53:00,223 --> 03:53:01,424 ENVIRONMENTAL IMPLICATIONS TO 6295 03:53:01,424 --> 03:53:08,965 THESE VARIABLES THAT ARE MORE 6296 03:53:08,965 --> 03:53:10,300 ENVIRONMENTAL. 6297 03:53:10,300 --> 03:53:13,136 THERE'S STILL INCLUSION OF 6298 03:53:13,136 --> 03:53:14,337 VARIABLES WITH GENETIC COMPONENT 6299 03:53:14,337 --> 03:53:16,473 BUT WOULD BE INTERESTING TO SEE 6300 03:53:16,473 --> 03:53:18,475 THAT GENETIC AND GENE 6301 03:53:18,475 --> 03:53:19,476 ENVIRONMENT, SOMETHING I HAVEN'T 6302 03:53:19,476 --> 03:53:20,343 PHYSICALLY DONE BUT THOUGHT 6303 03:53:20,343 --> 03:53:21,778 ABOUT THE PROCESS AND INCLUSION 6304 03:53:21,778 --> 03:53:31,521 OF VARIABLES WITHIN THE 6305 03:53:31,521 --> 03:53:32,923 EXPOSOME. 6306 03:53:32,923 --> 03:53:34,124 >> ANOTHER QUICK QUESTION? 6307 03:53:34,124 --> 03:53:37,093 THAT WAS REALLY FANTASTIC, 6308 03:53:37,093 --> 03:53:37,527 REALLY INTERESTING. 6309 03:53:37,527 --> 03:53:41,698 ANYBODY ELSE HAVE A QUICK ONE? 6310 03:53:41,698 --> 03:53:43,099 YEAH, GO AHEAD. 6311 03:53:43,099 --> 03:53:46,102 SORRY, ONLINE. 6312 03:53:46,102 --> 03:53:46,770 GO AHEAD. 6313 03:53:46,770 --> 03:53:48,571 >> YEAH, CONGRATULATIONS. 6314 03:53:48,571 --> 03:53:50,106 THIS IS REALLY GREAT WORK AND 6315 03:53:50,106 --> 03:53:57,113 ROLE MOD EL FOR RESEARCH IN MANY 6316 03:53:57,113 --> 03:53:58,648 HEALTH CONDITIONS, INCLUDING THE 6317 03:53:58,648 --> 03:53:59,683 ONE YOU STUDIED. 6318 03:53:59,683 --> 03:54:03,920 I WAS WONDERING YOU MENTIONED 6319 03:54:03,920 --> 03:54:05,021 SECONDHAND SMOKE EXPOSURE DURING 6320 03:54:05,021 --> 03:54:09,159 PREGNANCY OR EARLY IN LIFE. 6321 03:54:09,159 --> 03:54:10,393 WONDERING OTHER NEURO TOXICANT 6322 03:54:10,393 --> 03:54:13,330 EXPOSURE THAT COULD BE RELEVANT 6323 03:54:13,330 --> 03:54:16,399 WITHIN THE ENVIRONMENTAL TEAM IF 6324 03:54:16,399 --> 03:54:19,569 YOU HAVE ANY ACCESS FOR INSTANCE 6325 03:54:19,569 --> 03:54:22,605 LEAD EXPOSURE, HOW INFLUENCE 6326 03:54:22,605 --> 03:54:23,306 THESE NEUROTOXICANT EXPOSURES IN 6327 03:54:23,306 --> 03:54:25,775 EARLY LIFE COULD BE RELEVANT AND 6328 03:54:25,775 --> 03:54:27,978 WITHIN THE IDEA OF THE EXPOSOME 6329 03:54:27,978 --> 03:54:30,814 IT COULD BE SUPER INTERESTING TO 6330 03:54:30,814 --> 03:54:32,882 INCLUDE BUT I'M NOT SURE IF THAT 6331 03:54:32,882 --> 03:54:34,985 TYPE OF INFORMATION IS AVAILABLE 6332 03:54:34,985 --> 03:54:36,486 IN THIS STUDY. 6333 03:54:36,486 --> 03:54:38,588 >> YES, THAT TYPE OF INFORMATION 6334 03:54:38,588 --> 03:54:41,658 IS AVAILABLE WITHIN THE GEO 6335 03:54:41,658 --> 03:54:43,927 CODED MEASURES, SO ONE OF THE 6336 03:54:43,927 --> 03:54:45,795 SIGNIFICANT VARIABLES WE SAW WAS 6337 03:54:45,795 --> 03:54:48,431 THE PERCENT OF THE POPULATION 6338 03:54:48,431 --> 03:54:50,734 BELOW POVERTY. 6339 03:54:50,734 --> 03:54:53,703 AND THAT WAS ACTUALLY BASED ON A 6340 03:54:53,703 --> 03:54:55,905 LEAD-RISK QUESTIONNAIRE, WELL, A 6341 03:54:55,905 --> 03:54:57,440 LEAD-RISK CENSUS TRACT. 6342 03:54:57,440 --> 03:54:58,641 SO, YES, IT'S POSSIBLE TO LOOK 6343 03:54:58,641 --> 03:55:02,345 AT MORE OF THOSE NEUROTOXIC 6344 03:55:02,345 --> 03:55:03,880 VARIABLES AND GEO CODED MEASURES 6345 03:55:03,880 --> 03:55:04,881 DO INCLUDE THEM. 6346 03:55:04,881 --> 03:55:08,051 WE JUST HAPPEN TO SEE ONLY THESE 6347 03:55:08,051 --> 03:55:10,053 TWO VARIABLES THAT I EMPHASIZED 6348 03:55:10,053 --> 03:55:11,588 WERE SIGNIFICANT. 6349 03:55:11,588 --> 03:55:21,898 AND THEN JUST THEY 6350 03:55:25,201 --> 03:55:30,407 USED TOBACCO OR NOT WHILE 6351 03:55:30,407 --> 03:55:31,474 PREGNANT. 6352 03:55:31,474 --> 03:55:31,975 >> YEAH. 6353 03:55:31,975 --> 03:55:33,510 IT WAS INCREDIBLE. 6354 03:55:33,510 --> 03:55:36,279 UNFORTUNATELY TIME KEEPS ON 6355 03:55:36,279 --> 03:55:36,479 GOING. 6356 03:55:36,479 --> 03:55:38,248 WE CANNOT STOP IT. 6357 03:55:38,248 --> 03:55:40,683 WE HAVE TO GO NOT NEXT 6358 03:55:40,683 --> 03:55:46,556 PRESENTER, DR. NATHANIEL 6359 03:55:46,556 --> 03:55:47,057 HARNETT, NEUROSCIENTIST, 6360 03:55:47,057 --> 03:55:47,657 RESEARCH ON UNDERSTANDING THE 6361 03:55:47,657 --> 03:55:49,192 BRAIN BASIS FOR WHY SOME PEOPLE 6362 03:55:49,192 --> 03:55:53,129 ARE MORE LIKELY TO DEVELOP 6363 03:55:53,129 --> 03:55:55,198 STRESS-RELATED DISORDERS SUCH AS 6364 03:55:55,198 --> 03:55:59,135 PTSD AFTER TRAUMA, CURRENT WORK 6365 03:55:59,135 --> 03:56:00,370 LEVERAGES MAGNETIC RESONANCE 6366 03:56:00,370 --> 03:56:03,773 IMAGING TECHNIQUES INCLUDING 6367 03:56:03,773 --> 03:56:14,184 fMRI, STRUCTURAL fMRI, 6368 03:56:14,984 --> 03:56:17,654 DEFUSION WEIGHTED IMAGING FOR 6369 03:56:17,654 --> 03:56:18,721 SUSCEPTIBILITY, ELUCIDATING 6370 03:56:18,721 --> 03:56:21,491 NEURAL CIRCUITRY LINKED TO ACUTE 6371 03:56:21,491 --> 03:56:24,227 AND LONG-TERM DEVELOPMENT OF 6372 03:56:24,227 --> 03:56:27,397 PTSD AND IDENTIFYING ROBUST AND 6373 03:56:27,397 --> 03:56:28,364 GENERALIZABLE NEUROBIOLOGICAL 6374 03:56:28,364 --> 03:56:32,769 TARGETS FOR EARLY INTERVENTIONS 6375 03:56:32,769 --> 03:56:35,238 AND TREATMENTS, ULTIMATELY GOAL 6376 03:56:35,238 --> 03:56:36,473 TO DEVELOP PREDICTIVE AND 6377 03:56:36,473 --> 03:56:37,807 PREVENTIVE NEUROSCIENTIST BASED 6378 03:56:37,807 --> 03:56:41,744 TECHNIQUES TO REDUCE PREVALENCE 6379 03:56:41,744 --> 03:56:44,481 AND TRAUMA AND STRESS RELATED 6380 03:56:44,481 --> 03:56:44,747 DISORDERS. 6381 03:56:44,747 --> 03:56:45,782 DR. HARNETT, WELCOME. 6382 03:56:45,782 --> 03:56:46,449 TAKE IT OVER. 6383 03:56:46,449 --> 03:56:47,650 >> THANK YOU FOR THE 6384 03:56:47,650 --> 03:56:48,151 INTRODUCTION. 6385 03:56:48,151 --> 03:56:49,452 I HOPE YOU CAN HEAR ME, I'M 6386 03:56:49,452 --> 03:56:52,021 SORRY I CAN'T BE THERE IN 6387 03:56:52,021 --> 03:56:52,589 PERSON. 6388 03:56:52,589 --> 03:56:53,790 I HAD SOME ALTERNATIVE TRAVEL I 6389 03:56:53,790 --> 03:56:55,091 COULDN'T GET OUT OF. 6390 03:56:55,091 --> 03:56:56,292 I'M EXCITED TO PRESENT AS 6391 03:56:56,292 --> 03:57:01,764 SOMEONE WHO IS NOT REALLY AN 6392 03:57:01,764 --> 03:57:05,135 ABCD CONSORTIUM APPROACHING 6393 03:57:05,135 --> 03:57:07,237 STRUCTURALIZED INEQUITY IN THE 6394 03:57:07,237 --> 03:57:08,404 UNITED STATES IMPACTING WITHIN 6395 03:57:08,404 --> 03:57:09,606 ABCD AND OTHER STUDIES THAT 6396 03:57:09,606 --> 03:57:11,708 MIGHT BE IMPORTANT TO OUR 6397 03:57:11,708 --> 03:57:12,909 UNDERSTANDING OF THE 6398 03:57:12,909 --> 03:57:15,245 NEUROBIOLOGY OF DIFFERENT 6399 03:57:15,245 --> 03:57:17,180 PSYCHIATRIC DISORDERS. 6400 03:57:17,180 --> 03:57:22,018 IN MY LAB WE FOCUS ON 6401 03:57:22,018 --> 03:57:23,219 NEUROSUBSTRATES TO UNDERLIE 6402 03:57:23,219 --> 03:57:24,420 LEARNING, EXPRESSION, 6403 03:57:24,420 --> 03:57:24,721 REGULATION. 6404 03:57:24,721 --> 03:57:25,955 WE THINK THIS CIRCUIT IS 6405 03:57:25,955 --> 03:57:26,823 IMPORTANT FOR UNDERSTANDING OF 6406 03:57:26,823 --> 03:57:30,460 WHO IS GOING TO GO ON TO DEVELOP 6407 03:57:30,460 --> 03:57:32,195 PSYCHIATRIC DISEASES. 6408 03:57:32,195 --> 03:57:33,730 WE FOCUS ON AMYGDALA, REALLY 6409 03:57:33,730 --> 03:57:36,799 INVOLVED IN THREAT LEARNING, 6410 03:57:36,799 --> 03:57:39,102 FORMATION OF CUE THREAT 6411 03:57:39,102 --> 03:57:39,736 ASSOCIATION. 6412 03:57:39,736 --> 03:57:41,604 HIPPOCAMPUS IMPORTANT IN 6413 03:57:41,604 --> 03:57:42,305 MODULATING THE CONTEXTUAL 6414 03:57:42,305 --> 03:57:44,440 INFORMATION WE TAKE IN ABOUT OUR 6415 03:57:44,440 --> 03:57:46,843 ENVIRONMENT TO HELP MODULATE 6416 03:57:46,843 --> 03:57:48,711 AMYGDALA EMOTIONAL RESPONSE. 6417 03:57:48,711 --> 03:57:51,648 DIFFERENT COMPONENTS OF THE 6418 03:57:51,648 --> 03:57:53,750 PRE-FRONT CORTEX TO FACILITATE 6419 03:57:53,750 --> 03:57:54,651 EMOTIONAL RESPONSE OR DAMPEN 6420 03:57:54,651 --> 03:57:57,253 DEPENDING ON THE NEEDS WE HAVE 6421 03:57:57,253 --> 03:57:59,522 WITHIN ANY PARTICULAR SITUATION. 6422 03:57:59,522 --> 03:58:02,158 WE KNOW THIS IS TRANSDIAGNOSTIC 6423 03:58:02,158 --> 03:58:03,259 IMPORTANT FOR UNDERSTANDING 6424 03:58:03,259 --> 03:58:05,762 PSYCHIATRIC DISORDERS SO IF YOU 6425 03:58:05,762 --> 03:58:06,996 LOOK AT META-ANALYSES OVER, SAY, 6426 03:58:06,996 --> 03:58:08,831 MOSTLY THE LAST FIVE YEARS YOU 6427 03:58:08,831 --> 03:58:11,901 SEE THIS CIRCUIT IS IMPLICATED 6428 03:58:11,901 --> 03:58:13,970 IN GENERALIZED ANXIETY DISORDER, 6429 03:58:13,970 --> 03:58:15,305 MAJOR DEPRESSIVE DISORDER AND 6430 03:58:15,305 --> 03:58:17,540 PTSD, OFTEN WHAT WE FOCUS ON IN 6431 03:58:17,540 --> 03:58:18,474 MY LAB. 6432 03:58:18,474 --> 03:58:22,278 I THINK THAT PTSD IS A REALLY 6433 03:58:22,278 --> 03:58:24,614 GOOD EXAMPLE THOUGH FOR 6434 03:58:24,614 --> 03:58:26,249 HIGHLIGHTING HOW FOCUSING ON 6435 03:58:26,249 --> 03:58:28,985 STRESS AS A GENERAL PRINCIPLE 6436 03:58:28,985 --> 03:58:30,186 REALLY MISSES IMPORTANT CAVEATS 6437 03:58:30,186 --> 03:58:32,488 AND DETAILS ABOUT HOW DIFFERENT 6438 03:58:32,488 --> 03:58:33,556 TYPES OF STRESSORS, DIFFERENT 6439 03:58:33,556 --> 03:58:36,526 TYPES OF EXPERIENCES MIGHT SORT 6440 03:58:36,526 --> 03:58:37,527 OF HAVE THIS MULTI-FACTORIAL 6441 03:58:37,527 --> 03:58:39,896 IMPACT ON THE BRAIN. 6442 03:58:39,896 --> 03:58:41,331 SO WE OFTEN THINK ABOUT FOR 6443 03:58:41,331 --> 03:58:44,500 EXAMPLE PTSD AS PEOPLE ARE 6444 03:58:44,500 --> 03:58:46,569 RELATIVELY HEALTHY, THEY 6445 03:58:46,569 --> 03:58:47,704 EXPERIENCE DISCRETE TRAUMATIC 6446 03:58:47,704 --> 03:58:49,072 EVENT AND DEVELOP PTSD. 6447 03:58:49,072 --> 03:58:51,941 REALITY IS THAT THERE ARE THINGS 6448 03:58:51,941 --> 03:58:53,243 THAT HAPPEN AROUND AND BEFORE 6449 03:58:53,243 --> 03:58:55,445 AND AFTER TRAUMATIC EVENT THAT 6450 03:58:55,445 --> 03:58:57,947 CAN MODULATE HOW PEOPLE RESPOND. 6451 03:58:57,947 --> 03:58:59,482 IF SOMEONE IS IN A CAR ACCIDENT 6452 03:58:59,482 --> 03:59:01,351 AND CAN'T GO BACK TO WORK THERE 6453 03:59:01,351 --> 03:59:02,352 ARE OTHER POSTTRAUMATIC 6454 03:59:02,352 --> 03:59:03,753 STRESSORS THAT OCCUR SUCH AS NOT 6455 03:59:03,753 --> 03:59:05,521 BEING ABLE TO PAY BILLS, THAT 6456 03:59:05,521 --> 03:59:07,790 CAN MODULATE HOW YOUR BRAIN AND 6457 03:59:07,790 --> 03:59:08,958 BODY REACTS TO DIFFERENT 6458 03:59:08,958 --> 03:59:10,326 STRESSORS AND HOW PEOPLE SHOW UP 6459 03:59:10,326 --> 03:59:15,565 WHEN THEY PARTICIPATE IN OUR 6460 03:59:15,565 --> 03:59:17,066 STUDIES, ASPECTS OF THE 6461 03:59:17,066 --> 03:59:20,503 TRAUMATIC EVENT, WHETHER THEY 6462 03:59:20,503 --> 03:59:21,938 WERE THE DRIVER, PASSENGER, 6463 03:59:21,938 --> 03:59:23,139 PEDESTRIAN, HOW THEY INTERPRET 6464 03:59:23,139 --> 03:59:26,075 THE EVENT THAT OCCURRED. 6465 03:59:26,075 --> 03:59:30,647 WE KNOW DIFFERENT STRESSORS LIKE 6466 03:59:30,647 --> 03:59:35,251 CHILDHOOD EXPERIENCES MODULATE 6467 03:59:35,251 --> 03:59:36,686 FURTHER EXPERIENCES TO STRESS 6468 03:59:36,686 --> 03:59:37,787 AND TRAUMA. 6469 03:59:37,787 --> 03:59:39,756 A REALLY IMPORTANT ASPECT ABOUT 6470 03:59:39,756 --> 03:59:41,391 ALL OF THESE DIFFERENT DISCRETE 6471 03:59:41,391 --> 03:59:44,460 EVENTS THEY ARE NOT RANDOMLY 6472 03:59:44,460 --> 03:59:44,761 DISTRIBUTED. 6473 03:59:44,761 --> 03:59:46,863 THAT THE ENVIRONMENTS WE LIVE 6474 03:59:46,863 --> 03:59:49,499 IN, THAT CONTRIBUTE TO THE 6475 03:59:49,499 --> 03:59:52,669 EXPOSURES OF STRESS ARE IN MANY 6476 03:59:52,669 --> 03:59:54,203 WAYS DESIGNED, IN SPECIFIC WAYS, 6477 03:59:54,203 --> 03:59:56,272 AS I THINK AN IMPORTANT EXAMPLE 6478 03:59:56,272 --> 03:59:59,108 I DID MY GRADUATE TRAINING AT 6479 03:59:59,108 --> 03:59:59,575 UNIVERSITY OF ALABAMA 6480 03:59:59,575 --> 04:00:00,009 BIRMINGHAM. 6481 04:00:00,009 --> 04:00:09,719 IF YOU KNOW ANYTHING ABOUT IT, 6482 04:00:09,719 --> 04:00:12,689 IT HAS A STORIED CIVIL RIGHTS 6483 04:00:12,689 --> 04:00:16,526 HISTORY. 6484 04:00:16,526 --> 04:00:20,663 THIS MAP OF REDLINE TO SEGREGATE 6485 04:00:20,663 --> 04:00:21,464 BLACK INDIVIDUALS FROM WHITE 6486 04:00:21,464 --> 04:00:23,099 INDIVIDUALS WITHIN THE CITY. 6487 04:00:23,099 --> 04:00:24,067 WHAT'S INTERESTING THOUGH IS 6488 04:00:24,067 --> 04:00:28,004 THAT IF YOU COMPARE A MAP OF 6489 04:00:28,004 --> 04:00:29,639 REDLINING IN BIRMINGHAM TO FOOD 6490 04:00:29,639 --> 04:00:33,142 DESERTS IN BIRMINGHAM IT MATCHES 6491 04:00:33,142 --> 04:00:38,614 REALLY, REALLY WELL. 6492 04:00:38,614 --> 04:00:39,949 SO USDA FOOD DESERTS ARE ON THE 6493 04:00:39,949 --> 04:00:43,753 NORTH SIDE WHERE THE LARGEST 6494 04:00:43,753 --> 04:00:44,754 CONCENTRATION OF BLACK 6495 04:00:44,754 --> 04:00:46,923 INDIVIDUALS IN BIRMINGHAM LIVE. 6496 04:00:46,923 --> 04:00:48,491 MAP TO OTHER NEIGHBORHOOD 6497 04:00:48,491 --> 04:00:52,195 FACTORS, FOR EXAMPLE A MAP OF 6498 04:00:52,195 --> 04:00:52,762 THE AREA DEPRIVATION INDEX, 6499 04:00:52,762 --> 04:00:54,163 NEIGHBORHOOD DISADVANTAGE WHERE 6500 04:00:54,163 --> 04:00:58,334 THE WARMER COLORS ARE MORE 6501 04:00:58,334 --> 04:01:02,171 DISADVANTAGED NEIGHBORHOODS, 6502 04:01:02,171 --> 04:01:04,340 BLUE ARE MORE ADVANTAGED. 6503 04:01:04,340 --> 04:01:05,641 A LOT OF DISADVANTAGE IS 6504 04:01:05,641 --> 04:01:06,976 CLUSTERED IN THE NORTH WHERE 6505 04:01:06,976 --> 04:01:08,811 MAJORITY OF BLACK INDIVIDUALS 6506 04:01:08,811 --> 04:01:11,447 LIVE IN BIRMINGHAM. 6507 04:01:11,447 --> 04:01:14,884 THERE'S AN IMPORTANT CONTEXTUAL 6508 04:01:14,884 --> 04:01:16,519 MODULATION OF WHAT ENVIRONMENT 6509 04:01:16,519 --> 04:01:19,889 IS CREATED AND WHO LIVES THERE, 6510 04:01:19,889 --> 04:01:20,990 NOT JUST AN EXAMPLE TO 6511 04:01:20,990 --> 04:01:22,959 BIRMINGHAM OR BALTIMORE OR OTHER 6512 04:01:22,959 --> 04:01:24,894 AREAS, IT REALLY IS A NATIONWIDE 6513 04:01:24,894 --> 04:01:25,361 PROBLEM. 6514 04:01:25,361 --> 04:01:30,066 SO THIS IS DATA FROM CHILD 6515 04:01:30,066 --> 04:01:31,300 TRENDS, PERCENTAGE OF CHURN, ONE 6516 04:01:31,300 --> 04:01:34,670 OR TWO OR MORE CHILDHOOD ADVERSE 6517 04:01:34,670 --> 04:01:36,205 EXPERIENCES, IT DOESN'T MATTER 6518 04:01:36,205 --> 04:01:38,908 IN NEW ENGLAND AREA, 6519 04:01:38,908 --> 04:01:39,375 MID-ATLANTIC, PACIFIC, 6520 04:01:39,375 --> 04:01:49,819 INDIVIDUALS WHO COME FROM 6521 04:01:50,787 --> 04:01:52,121 RACIALLY MARGINALIZED ARE 6522 04:01:52,121 --> 04:01:53,055 EXPOSED TO STRESSORS, THIS IS 6523 04:01:53,055 --> 04:01:55,024 JUST WHAT THE DATA ARE. 6524 04:01:55,024 --> 04:01:56,025 COMPARED ACROSS OTHER DATASETS, 6525 04:01:56,025 --> 04:01:57,994 WORK THAT WE'VE DONE WITH AURORA 6526 04:01:57,994 --> 04:02:00,496 STUDY, NIMH, WE'VE BEEN ABLE TO 6527 04:02:00,496 --> 04:02:02,799 SEE OTHER FACTORS LIKE 6528 04:02:02,799 --> 04:02:03,566 NEIGHBORHOOD DISADVANTAGE OR 6529 04:02:03,566 --> 04:02:07,270 EVEN AMOUNT OF GREEN SPACE 6530 04:02:07,270 --> 04:02:11,107 AROUND PARTICIPANTS IS PARTIALLY 6531 04:02:11,107 --> 04:02:11,874 DEPENDENT ON ETHNIC AND RACIAL 6532 04:02:11,874 --> 04:02:12,542 GROUP OF. 6533 04:02:12,542 --> 04:02:16,145 THIS IS GOING TO HAVE DOWNSTREAM 6534 04:02:16,145 --> 04:02:18,014 INDIVIDUALS ON INDIVIDUALS' 6535 04:02:18,014 --> 04:02:18,881 HEALTH. 6536 04:02:18,881 --> 04:02:19,849 ANOTHER INTERESTING MICROCOSM 6537 04:02:19,849 --> 04:02:20,917 EXAMPLE THERE'S AN INTERESTING 6538 04:02:20,917 --> 04:02:24,987 STUDY DONE BY NANCY KRIEGER'S 6539 04:02:24,987 --> 04:02:26,189 GROUP, LOOKING AT PREMATURE 6540 04:02:26,189 --> 04:02:27,957 DEATH RATES BY WHERE PEOPLE -- 6541 04:02:27,957 --> 04:02:31,060 IF YOU'VE BEEN TO BOSTON WE HAVE 6542 04:02:31,060 --> 04:02:34,096 THE T, OUR VERY WONDERFUL PUBLIC 6543 04:02:34,096 --> 04:02:34,464 TRANSIT SYSTEM. 6544 04:02:34,464 --> 04:02:36,966 IF YOU MAP WHERE PEOPLE GET OFF 6545 04:02:36,966 --> 04:02:40,903 ON THE T BY PREMATURE DEATH, 6546 04:02:40,903 --> 04:02:44,173 AREAS LIKE MAVERICK HAVE HIGHEST 6547 04:02:44,173 --> 04:02:44,373 RATES. 6548 04:02:44,373 --> 04:02:46,142 IF YOU OVERLAY RACIAL AND ETHNIC 6549 04:02:46,142 --> 04:02:51,948 DEMOGRAPHICS YOU SEE THE AREAS 6550 04:02:51,948 --> 04:02:53,015 LIKE MAVERICK, HISPANIC, DUDLEY 6551 04:02:53,015 --> 04:02:56,452 SQUARE BLACK, THERE'S AN OVERLAP 6552 04:02:56,452 --> 04:02:58,187 IN TERMS OF NEIGHBORHOODS 6553 04:02:58,187 --> 04:03:02,124 DESIGNED, WHAT TYPE OF 6554 04:03:02,124 --> 04:03:02,625 PARTICIPANTS ARE, WHAT 6555 04:03:02,625 --> 04:03:04,227 SOCIODEMOGRAPHICS OF PEOPLE LIVE 6556 04:03:04,227 --> 04:03:04,994 THERE AND ASSOCIATED HEALTH 6557 04:03:04,994 --> 04:03:07,063 OUTCOMES THAT ARE REALLY 6558 04:03:07,063 --> 04:03:07,330 IMPORTANT. 6559 04:03:07,330 --> 04:03:10,366 AND SO THE KEY LYNCH POINT FOR 6560 04:03:10,366 --> 04:03:15,404 US IS THAT THESE SAMPLES THAT 6561 04:03:15,404 --> 04:03:18,341 WE'RE ABLE TO DRAW, WHERE WE'RE 6562 04:03:18,341 --> 04:03:23,813 DOING NEUROIMAGING STUDIES HAS 6563 04:03:23,813 --> 04:03:26,549 DOWNSTREAM IMPACTS TO GENERATE 6564 04:03:26,549 --> 04:03:29,318 PHENOTYPES AND ABILITY TO 6565 04:03:29,318 --> 04:03:30,953 UNDERSTAND JUST HOW 6566 04:03:30,953 --> 04:03:31,587 GENERALIZABLE NEURO PHENOTYPES 6567 04:03:31,587 --> 04:03:33,456 ARE IF WE WANT TO MOVE TOWARD 6568 04:03:33,456 --> 04:03:34,557 IMPORTANT PRECISION MEDICINE 6569 04:03:34,557 --> 04:03:36,225 APPROACHES FOR PREDICTION AND 6570 04:03:36,225 --> 04:03:39,595 PREVENTION OF THINGS LIKE PTSD, 6571 04:03:39,595 --> 04:03:44,300 DEPRESSION, ANXIETY. 6572 04:03:44,300 --> 04:03:45,935 WE'VE BEEN LOOKING TO SEE HOW 6573 04:03:45,935 --> 04:03:49,238 SOON IN TERMS OF NEUROIMAGING 6574 04:03:49,238 --> 04:03:56,145 CAN WE SEE BIOLOGICAL EMBEDDING 6575 04:03:56,145 --> 04:03:59,982 OF RACIAL INEQUITIES AND 6576 04:03:59,982 --> 04:04:06,222 DOWNSTREAM IMPACTS OF THAT. 6577 04:04:06,222 --> 04:04:07,757 NATALIE DEMORENAY WANTED TO LOOK 6578 04:04:07,757 --> 04:04:09,825 HOW INEQUITY WAS TRIED TO 6579 04:04:09,825 --> 04:04:10,826 DIFFERENCE IN BRAIN STRUCTURE 6580 04:04:10,826 --> 04:04:13,195 BETWEEN WHITE AND BLACK 6581 04:04:13,195 --> 04:04:13,663 CHILDREN. 6582 04:04:13,663 --> 04:04:19,835 THE ABCD STUDY WAS PICKING UP 6583 04:04:19,835 --> 04:04:20,369 STEAM. 6584 04:04:20,369 --> 04:04:23,739 NATALIE LEVERAGED THIS TO GET AN 6585 04:04:23,739 --> 04:04:26,175 INDEX OF TIME SEVERAL COURSE 6586 04:04:26,175 --> 04:04:28,678 METRICS OF EXPERIENCES AND 6587 04:04:28,678 --> 04:04:29,979 CONTEXTS THAT PARTICIPANTS HAD 6588 04:04:29,979 --> 04:04:31,647 WHILE PARTICIPATING. 6589 04:04:31,647 --> 04:04:33,616 SHE LOOKED AT FAMILY CONFLICT, 6590 04:04:33,616 --> 04:04:36,552 HARDSHIP, AMOUNT OF TRAUMA THAT 6591 04:04:36,552 --> 04:04:37,753 PARTICIPANTS WERE ENDORSING, 6592 04:04:37,753 --> 04:04:39,689 CAREGIVER INCOME AND EDUCATION, 6593 04:04:39,689 --> 04:04:42,124 EMPLOYMENT, AS WELL AS AREA OF 6594 04:04:42,124 --> 04:04:45,928 DEPRIVATION INDEX TO GET A 6595 04:04:45,928 --> 04:04:46,629 MEASURE OF NEIGHBORHOOD 6596 04:04:46,629 --> 04:04:47,163 DISADVANTAGED. 6597 04:04:47,163 --> 04:04:50,766 WE LOOKED AT GRAY MATTER VOLUME 6598 04:04:50,766 --> 04:04:54,170 OF THE SAME NEUROCIRCUIT, 6599 04:04:54,170 --> 04:04:56,105 SUBCOMPONENTS OF PREFRONTAL 6600 04:04:56,105 --> 04:04:57,006 CORTEX, AMYGDALA AND 6601 04:04:57,006 --> 04:04:58,107 HIPPOCAMPUS. 6602 04:04:58,107 --> 04:05:00,076 BEFORE WE GO FURTHER, I THINK 6603 04:05:00,076 --> 04:05:03,245 IT'S IMPORTANT TO CONTEXTUALIZE 6604 04:05:03,245 --> 04:05:05,514 WHEN WE TALK ABOUT DIFFERENCES 6605 04:05:05,514 --> 04:05:06,515 IN NEUROBIOLOGY WE'RE NOT TALK 6606 04:05:06,515 --> 04:05:09,352 BECOME SKIN COLOR. 6607 04:05:09,352 --> 04:05:12,221 WE'RE TALKING ABOUT A VARIED 6608 04:05:12,221 --> 04:05:15,391 COLLECTION OF DIFFERENCES REALLY 6609 04:05:15,391 --> 04:05:17,226 OWING TO MAJOR HISTORICAL 6610 04:05:17,226 --> 04:05:19,228 INFLUENCES THAT IMPACT ECONOMIC, 6611 04:05:19,228 --> 04:05:24,266 ENVIRONMENTAL, OTHER TYPES OF 6612 04:05:24,266 --> 04:05:25,101 FACTORS ASSOCIATED WITH BRAIN 6613 04:05:25,101 --> 04:05:25,401 DEVELOPMENT. 6614 04:05:25,401 --> 04:05:30,806 IF YOU LOOK AT ABCD STUDY DATA 6615 04:05:30,806 --> 04:05:33,442 FROM 2.01, WHAT NOW IS ABLE TO 6616 04:05:33,442 --> 04:05:34,944 SHOW IS COMPARED TO WHITE 6617 04:05:34,944 --> 04:05:36,612 CHILDREN, BLACK CHILDREN OF THE 6618 04:05:36,612 --> 04:05:39,015 STUDY HAD CAREGIVERS WITH LESS 6619 04:05:39,015 --> 04:05:41,217 EDUCATION AND WERE MORE OFTEN 6620 04:05:41,217 --> 04:05:42,518 UNEMPLOYED, LOWER FAMILY INCOME, 6621 04:05:42,518 --> 04:05:45,254 AND WERE COMING FROM 6622 04:05:45,254 --> 04:05:46,022 DISADVANTAGED NEIGHBORHOODS, 6623 04:05:46,022 --> 04:05:47,323 EXPERIENCES MORE FAMILY 6624 04:05:47,323 --> 04:05:48,324 CONFLICT, FINANCIAL HARDSHIP, 6625 04:05:48,324 --> 04:05:49,792 ALSO ENDORSING GREATER NUMBER OF 6626 04:05:49,792 --> 04:05:51,260 TRAUMATIC EVENTS. 6627 04:05:51,260 --> 04:05:53,562 THIS IS ABOUT 9 TO 10 YEARS OLD, 6628 04:05:53,562 --> 04:05:55,765 NOT SEEING A HUGE NUMBER, EVEN 6629 04:05:55,765 --> 04:05:58,401 AT THAT AGE SEEING RACE-RELATED 6630 04:05:58,401 --> 04:06:00,703 DIFFERENCES, IN THE NUMBER OF 6631 04:06:00,703 --> 04:06:02,238 TRAUMATIC EVENTS ENDORSED BY 6632 04:06:02,238 --> 04:06:03,773 BOTH CHILDREN AND PARENT. 6633 04:06:03,773 --> 04:06:06,909 SO WHEN WE WENT TO LOOK AT 6634 04:06:06,909 --> 04:06:07,710 NEUROIMAGING DATA, VERY FIRST 6635 04:06:07,710 --> 04:06:09,979 THING WE WANTED TO SHOW IF WE 6636 04:06:09,979 --> 04:06:12,181 BREAK THINGS DOWN BY THESE 6637 04:06:12,181 --> 04:06:14,483 DIFFERENT ASPECTS OF THREAT 6638 04:06:14,483 --> 04:06:15,885 NEUROBIOLOGY WE DO SEE 6639 04:06:15,885 --> 04:06:18,421 DIFFERENCES IN VOLUME AS 6640 04:06:18,421 --> 04:06:20,790 PROPORTION OF THE GENERAL BRAIN 6641 04:06:20,790 --> 04:06:22,124 SIZE BETWEEN WHITE AND BLACK 6642 04:06:22,124 --> 04:06:23,659 CHILDREN IN THE STUDY. 6643 04:06:23,659 --> 04:06:25,961 I LIKE TO SHOW THIS GRAPH TO 6644 04:06:25,961 --> 04:06:27,196 ACKNOWLEDGE THEY ARE NOT 6645 04:06:27,196 --> 04:06:28,931 DIFFERENT EXPERIENCE OF 6646 04:06:28,931 --> 04:06:29,231 INDIVIDUALS. 6647 04:06:29,231 --> 04:06:31,000 THERE'S OVERLAP BETWEEN THE 6648 04:06:31,000 --> 04:06:31,233 GROUPS. 6649 04:06:31,233 --> 04:06:33,169 I'LL SHOW DATA TO SUGGEST THIS, 6650 04:06:33,169 --> 04:06:36,772 THAT WE THINK WE'RE LOOKING AT 6651 04:06:36,772 --> 04:06:38,407 INFLUENCE OF EARLY LIFE 6652 04:06:38,407 --> 04:06:39,408 INEQUITIES HAVING SMALL IMPACTS 6653 04:06:39,408 --> 04:06:42,712 NOW BUT MIGHT HAVE LARGER 6654 04:06:42,712 --> 04:06:43,713 IMPACTS AS THESE INDIVIDUALS 6655 04:06:43,713 --> 04:06:46,749 CONTINUE TO LIVE IN THESE 6656 04:06:46,749 --> 04:06:48,517 ENVIRONMENTS AND REAP THE 6657 04:06:48,517 --> 04:06:51,353 DETRIMENTS OF THE STRESSOR 6658 04:06:51,353 --> 04:06:51,654 EXPOSURES. 6659 04:06:51,654 --> 04:06:54,623 WE THINK THESE ARE SMALL BUT 6660 04:06:54,623 --> 04:06:55,491 STILL SIGNIFICANT. 6661 04:06:55,491 --> 04:06:58,027 SO THE NEXT THING THAT NATALIE 6662 04:06:58,027 --> 04:07:00,996 LOOKED AT WAS BECAUSE WE'RE SO 6663 04:07:00,996 --> 04:07:03,399 INTERESTED IN PTSD, WE THINK 6664 04:07:03,399 --> 04:07:06,202 BRAIN REGIONS ARE TIED DO THESE 6665 04:07:06,202 --> 04:07:07,403 SORT OF EARLY LIFE INEQUITIES 6666 04:07:07,403 --> 04:07:09,171 ALSO CONTRIBUTE TO PTSD 6667 04:07:09,171 --> 04:07:09,505 SYMPTOMS? 6668 04:07:09,505 --> 04:07:10,506 WE DO SEE THAT. 6669 04:07:10,506 --> 04:07:14,543 IF WE ADD ALL THE COURSE METRICS 6670 04:07:14,543 --> 04:07:16,645 OF ADVERSITY INTO THE MODEL WE 6671 04:07:16,645 --> 04:07:18,514 SEE SIGNIFICANT PREDICTION OF 6672 04:07:18,514 --> 04:07:21,784 PTSD SYMPTOMS IN THESE KIDS 9 TO 6673 04:07:21,784 --> 04:07:23,853 10 YEARS OLD, SIGNIFICANT 6674 04:07:23,853 --> 04:07:25,621 EFFECTS LIKE FAMILY INCOME, 6675 04:07:25,621 --> 04:07:26,388 MATERIAL HARDSHIP, FAMILY 6676 04:07:26,388 --> 04:07:29,325 CONFLICT AND TRAUMA HISTORY. 6677 04:07:29,325 --> 04:07:32,528 WE ALSO LOOKED AT HOW BRAIN 6678 04:07:32,528 --> 04:07:34,930 VOLUMES WE MEASURED -- THAT YOU 6679 04:07:34,930 --> 04:07:36,165 ALL MEASURED WERE ASSOCIATED 6680 04:07:36,165 --> 04:07:39,535 WITH PTSD SYMPTOMS IN THESE 6681 04:07:39,535 --> 04:07:43,506 INDIVIDUALS SO LOOKING AT 6682 04:07:43,506 --> 04:07:45,241 CINGULATE CORTEX, FRONTAL GYRUS. 6683 04:07:45,241 --> 04:07:47,443 WHAT NATALIE DID WAS RUN A 6684 04:07:47,443 --> 04:07:49,178 SERIES OF PARALLEL MEDIATION 6685 04:07:49,178 --> 04:07:49,545 ANALYSES. 6686 04:07:49,545 --> 04:07:57,820 WHAT IF WE LIVED IN A WORLD WE 6687 04:07:57,820 --> 04:07:58,621 COULD NORMALIZE EMPLOYMENT, 6688 04:07:58,621 --> 04:08:01,123 EDUCATION, INCOME, ET CETERA 6689 04:08:01,123 --> 04:08:02,958 DIFFERENCES, SHOWING THAT THIS 6690 04:08:02,958 --> 04:08:04,493 DOES ATTENUATE SOME ASSOCIATIONS 6691 04:08:04,493 --> 04:08:07,329 THAT WE SEE WITH PTSD SUGGESTING 6692 04:08:07,329 --> 04:08:10,132 THAT THE SORT OF IMPACT OF THESE 6693 04:08:10,132 --> 04:08:11,367 INEQUITIES IS MULTI-FACETED. 6694 04:08:11,367 --> 04:08:14,537 SHE ALSO LOOKED AT THIS IN TERMS 6695 04:08:14,537 --> 04:08:16,172 OF TRYING TO EXPLAIN RACIAL 6696 04:08:16,172 --> 04:08:18,040 DIFFERENCES IN BRAIN VOLUME 6697 04:08:18,040 --> 04:08:19,141 WITHIN THESE INDIVIDUALS. 6698 04:08:19,141 --> 04:08:21,977 SO ON THE GRAPH ON THE TOP, YOU 6699 04:08:21,977 --> 04:08:23,813 CAN SEE AREAS WHERE WE ACTUALLY 6700 04:08:23,813 --> 04:08:25,681 WERE ABLE TO SHOW SIGNIFICANT 6701 04:08:25,681 --> 04:08:27,783 PARTIAL MEDIATION OF THESE 6702 04:08:27,783 --> 04:08:31,086 RACE-RELATED DIFFERENCES BY 6703 04:08:31,086 --> 04:08:32,188 ACCOUNTING FOR RACIAL 6704 04:08:32,188 --> 04:08:34,323 INEQUITIES, ON THE TABLE AT THE 6705 04:08:34,323 --> 04:08:39,962 BOTTOM, SOME REGIONS UP TO 50% 6706 04:08:39,962 --> 04:08:41,797 DIFFERENCES -- WOULD YOU MIND 6707 04:08:41,797 --> 04:08:42,031 MUTING? 6708 04:08:42,031 --> 04:08:42,631 THANK YOU. 6709 04:08:42,631 --> 04:08:44,867 WE WERE ABLE TO SEE SOME OF 6710 04:08:44,867 --> 04:08:47,837 THESE UP TO 50% OF THE RACIAL 6711 04:08:47,837 --> 04:08:50,439 DIFFERENCES ACCOUNTED FOR BY 6712 04:08:50,439 --> 04:08:52,975 LOOKING AT AND ACCOUNTING FOR 6713 04:08:52,975 --> 04:08:53,742 RACIAL INEQUITIES. 6714 04:08:53,742 --> 04:08:58,247 WE THINK TO US AT THE VERY BASIS 6715 04:08:58,247 --> 04:09:07,089 THIS SUGGESTION ASPECTS OF 6716 04:09:07,089 --> 04:09:08,858 INEQUITY, STRUCTURAL RACISM 6717 04:09:08,858 --> 04:09:12,561 WE'VE BEEN INTERESTED, I'LL SO 6718 04:09:12,561 --> 04:09:13,495 UNPUBLISHED DATA, HOW THIS MIGHT 6719 04:09:13,495 --> 04:09:14,430 CONTINUE LONG TERM. 6720 04:09:14,430 --> 04:09:16,632 WHAT HAPPENS AS THESE 6721 04:09:16,632 --> 04:09:19,568 INDIVIDUALS MOVE FROM 9 TO 10 TO 6722 04:09:19,568 --> 04:09:23,072 SAY 11 TO 12, 13 TO 15 AND SO 6723 04:09:23,072 --> 04:09:23,239 ON. 6724 04:09:23,239 --> 04:09:28,777 WE'VE BEEN LOOKING AT DATA FROM 6725 04:09:28,777 --> 04:09:32,381 4.0 TO HONE ON IMPACTS AT 6726 04:09:32,381 --> 04:09:33,716 INDIVIDUAL LEVELS OF INNOVATES, 6727 04:09:33,716 --> 04:09:36,051 LIKE INCOME, GENERAL EXPOSURE TO 6728 04:09:36,051 --> 04:09:36,986 INTERPERSONAL DISCRIMINATION, 6729 04:09:36,986 --> 04:09:39,054 ALSO AT THE NEIGHBORHOOD LEVEL 6730 04:09:39,054 --> 04:09:42,992 IF WE UTILIZE NEWLY RELEASED 6731 04:09:42,992 --> 04:09:46,395 MEASURES LIKE INDEX OF 6732 04:09:46,395 --> 04:09:50,866 STRUCTURAL STIGMA, STATE LEVEL 6733 04:09:50,866 --> 04:09:53,636 MEASURES OF NEIGHBORS TO ASK DO 6734 04:09:53,636 --> 04:09:55,037 WE STILL SEE RACE-RELATED 6735 04:09:55,037 --> 04:09:56,805 DIFFERENCES AS INDIVIDUALS GET 6736 04:09:56,805 --> 04:09:59,208 OLDER, ARE WE ABLE TO ATTENUATE 6737 04:09:59,208 --> 04:10:02,044 BY ACCOUNTING FOR MEASURES OF 6738 04:10:02,044 --> 04:10:04,813 INEQUITY, ALSO LEVERAGENING NEW 6739 04:10:04,813 --> 04:10:09,418 COMPUTATIONAL TECHNIQUES LIKE 6740 04:10:09,418 --> 04:10:14,356 NORMATIVE MODELING TO TRY TO 6741 04:10:14,356 --> 04:10:16,625 ACCOUNT FOR INTERGEOGRAPHICAL 6742 04:10:16,625 --> 04:10:19,929 DIFFERENCES, ALSO ACCOUNTING FOR 6743 04:10:19,929 --> 04:10:22,031 OTHER TIMES OF GLOBAL GEOGRAPHY 6744 04:10:22,031 --> 04:10:24,166 THAT MIGHT HAVE IMPACT ON 6745 04:10:24,166 --> 04:10:24,767 NEUROIMAGING FINDINGS. 6746 04:10:24,767 --> 04:10:27,269 I WANTED TO SHOW THESE QUICKLY 6747 04:10:27,269 --> 04:10:28,904 TO HIGHLIGHT THAT REGARDLESS OF 6748 04:10:28,904 --> 04:10:36,245 HOW WE CHOOSE TO MODEL DATA, 6749 04:10:36,245 --> 04:10:37,579 WHETHER STANDARD UNIVARIATE, OR 6750 04:10:37,579 --> 04:10:39,548 IF WE USE POPULATION LEVEL 6751 04:10:39,548 --> 04:10:41,717 NORMATIVE MODELS, WE DO SEE 6752 04:10:41,717 --> 04:10:43,285 RACE-RELATED DIFFERENCES START 6753 04:10:43,285 --> 04:10:48,624 TO CREEP UP, IN THIS CASE, 6754 04:10:48,624 --> 04:10:51,026 CORTICAL THICKNESS DATA 11 TO 12 6755 04:10:51,026 --> 04:10:51,794 YEARS OLD, ASSOCIATIONS WITH 6756 04:10:51,794 --> 04:10:55,230 INDIVIDUAL LEVELS OF INCOME OR 6757 04:10:55,230 --> 04:10:58,701 NATIONWIDE MEASURES, RESOURCE 6758 04:10:58,701 --> 04:11:00,769 AVAILABILITY, INDIVIDUAL 6759 04:11:00,769 --> 04:11:01,437 DISCRIMINATION, ALSO LOOKING AT 6760 04:11:01,437 --> 04:11:03,939 MEASURES OF STATE LEVEL RACISM. 6761 04:11:03,939 --> 04:11:06,542 IN THE SUBSET INDIVIDUALS WE'VE 6762 04:11:06,542 --> 04:11:08,978 BEEN ABLE TO FOLLOW WE ARE 6763 04:11:08,978 --> 04:11:14,550 SEEING THESE SAME SORTS OF 6764 04:11:14,550 --> 04:11:17,152 RACE-RELATED INEQUITIES. 6765 04:11:17,152 --> 04:11:19,021 WE'VE LOOKED IN TERMS OF VOLUME 6766 04:11:19,021 --> 04:11:21,123 AND AGAIN DOESN'T REALLY MATTER 6767 04:11:21,123 --> 04:11:22,858 WHAT MODALITY OR MODEL WE CHOOSE 6768 04:11:22,858 --> 04:11:26,895 TO RUN, WE REALLY CAN SEE 6769 04:11:26,895 --> 04:11:30,532 IMPACTS ACUTELY WITHIN THREAT 6770 04:11:30,532 --> 04:11:30,866 NEUROBIOLOGY. 6771 04:11:30,866 --> 04:11:34,670 ONCE WE ACCOUNT FOR DIFFERENCES 6772 04:11:34,670 --> 04:11:39,508 IN INCOME, DIFFERENCES IN STATE 6773 04:11:39,508 --> 04:11:43,212 LEVEL EXPOSURES OF 6774 04:11:43,212 --> 04:11:44,113 DISCRIMINATION, RESOURCE 6775 04:11:44,113 --> 04:11:48,584 AVAILABILITY, A SIGNIFICANT 6776 04:11:48,584 --> 04:11:51,653 AMOUNT IN MORPHOLOGY, EVEN MORE 6777 04:11:51,653 --> 04:11:54,923 THAN WHEN THEY WERE EARLY, 9 TO 6778 04:11:54,923 --> 04:11:57,359 10 YEARS OLD. 6779 04:11:57,359 --> 04:12:01,330 AS A LITTLE BIT OF DATA, BEYOND 6780 04:12:01,330 --> 04:12:03,399 FOCUSING ON T1 DATA WE KNOW 6781 04:12:03,399 --> 04:12:05,034 THESE REGIONS ARE IMPORTANT FOR 6782 04:12:05,034 --> 04:12:06,268 THREAT NEURAL PROCESSING BUT WE 6783 04:12:06,268 --> 04:12:08,971 ALSO KNOW THEY ARE CONNECTED 6784 04:12:08,971 --> 04:12:11,607 FUNCTIONALLY AND STRUCTURALLY BY 6785 04:12:11,607 --> 04:12:13,242 DIFFERENT SORTS OF ANATOMICAL 6786 04:12:13,242 --> 04:12:16,545 TRACK, LOOKING AT DORSAL 6787 04:12:16,545 --> 04:12:17,880 CINGULUM, WHITE MATTER MEASURES, 6788 04:12:17,880 --> 04:12:19,515 THAT MIGHT SUPPORT DIFFERENT 6789 04:12:19,515 --> 04:12:21,483 SORTS OF COGNITIVE AND EFFECTIVE 6790 04:12:21,483 --> 04:12:24,653 PROCESSES THAT MIGHT CONTRIBUTE 6791 04:12:24,653 --> 04:12:25,621 TO DOWNSTREAM EMOTIONAL 6792 04:12:25,621 --> 04:12:26,288 DIFFERENCES BETWEEN GROUPS. 6793 04:12:26,288 --> 04:12:28,590 ONE OF THE THINGS I WANT TO 6794 04:12:28,590 --> 04:12:31,560 HIGHLIGHT, WE'VE BEEN SHOWING 6795 04:12:31,560 --> 04:12:33,395 DATA THAT IS BLACK INDIVIDUALS 6796 04:12:33,395 --> 04:12:40,069 MIGHT HAVE LOWER VOLUME OR THICK 6797 04:12:40,069 --> 04:12:49,511 N ESS COMPARED TO WHITE, 6798 04:12:49,511 --> 04:12:52,147 REGARDLESS OF TIME POINT, 6799 04:12:52,147 --> 04:12:53,215 COMPARED TO WHITE INDIVIDUALS, 6800 04:12:53,215 --> 04:12:57,820 THIS MIGHT BE RELATED TO 6801 04:12:57,820 --> 04:12:58,587 DIFFERENCES IN EMOTIONAL COPING 6802 04:12:58,587 --> 04:13:01,890 STRATEGIES AS FUNCTION OF LIVING 6803 04:13:01,890 --> 04:13:02,758 IN MORE DISADVANTAGED 6804 04:13:02,758 --> 04:13:03,492 BACKGROUND. 6805 04:13:03,492 --> 04:13:06,462 SO JUST TO MAKE SURE WE'RE BACK 6806 04:13:06,462 --> 04:13:10,933 ON TIME, I'LL WRAP UP QUICKLY. 6807 04:13:10,933 --> 04:13:12,367 PART OF THE REASON WE'RE TRYING 6808 04:13:12,367 --> 04:13:14,336 TO UNDERSTAND WHAT'S HAPPENING 6809 04:13:14,336 --> 04:13:16,405 IN A LONGITUDINAL DEVELOPMENTAL 6810 04:13:16,405 --> 04:13:19,141 FRAMEWORK WHEN WE LOOK AT OLDER 6811 04:13:19,141 --> 04:13:21,210 ADULTS AND EMOTIONAL PROCESSES 6812 04:13:21,210 --> 04:13:24,513 WE STILL SEE RACE-RELATED 6813 04:13:24,513 --> 04:13:25,414 EFFECTS. 6814 04:13:25,414 --> 04:13:27,116 WE LOOKED AT NEUROPHYSIOLOGIC 6815 04:13:27,116 --> 04:13:32,421 RESPONSES TO THREAT IN WHITE AND 6816 04:13:32,421 --> 04:13:33,822 BLACK INDIVIDUALS, DURING 6817 04:13:33,822 --> 04:13:35,157 PAVLOVIAN TASK, HOW ARE THEY 6818 04:13:35,157 --> 04:13:37,426 RESPONDING TO THE THREAT, WE SEE 6819 04:13:37,426 --> 04:13:39,828 THIS EMOTIONAL BLUNTING IN BLACK 6820 04:13:39,828 --> 04:13:40,929 INDIVIDUALS COMPARED TO WHITE 6821 04:13:40,929 --> 04:13:42,364 INDIVIDUALS ALMOST COMPLETELY 6822 04:13:42,364 --> 04:13:45,868 MEDIATED BY DIFFERENCES IN 6823 04:13:45,868 --> 04:13:47,202 VIOLENCE EXPOSURE, AND FAMILY 6824 04:13:47,202 --> 04:13:47,436 INCOME. 6825 04:13:47,436 --> 04:13:52,674 IN THE AURORA STUDY WE SEE THESE 6826 04:13:52,674 --> 04:13:53,976 RESTING STATE CONNECTIVITY 6827 04:13:53,976 --> 04:13:55,944 DIFFERENCES BETWEEN BLACK, 6828 04:13:55,944 --> 04:13:57,379 WHITE, HISPANIC TRAUMA 6829 04:13:57,379 --> 04:13:59,248 SURVIVORS, THOSE CONNECTIVITY 6830 04:13:59,248 --> 04:14:00,849 PROFILES ARE DIFFERENTIALLY 6831 04:14:00,849 --> 04:14:02,050 PREDICTIVE OF PTSD SYMPTOMS IN 6832 04:14:02,050 --> 04:14:03,051 THOSE GROUP. 6833 04:14:03,051 --> 04:14:05,154 IN YOU'RE IN HISPANIC, WHITE OR 6834 04:14:05,154 --> 04:14:07,556 BLACK, SO DIFFERENT ASSOCIATION 6835 04:14:07,556 --> 04:14:09,191 WITH THREE-MONTH PTSD SYMPTOMS, 6836 04:14:09,191 --> 04:14:14,129 TRYING TO THINK ABOUT HOW THESE 6837 04:14:14,129 --> 04:14:16,398 EARLY EXPOSURES OF INEQUITY MAY 6838 04:14:16,398 --> 04:14:20,002 DRIVE DOWNSTREAM CHANGES IN 6839 04:14:20,002 --> 04:14:21,937 BRAIN DEVELOPMENT IS REALLY 6840 04:14:21,937 --> 04:14:24,873 IMPORTANT SPECIALLY AS WE THINK 6841 04:14:24,873 --> 04:14:26,975 ABOUT NATIONAL PREVALENCE OF 6842 04:14:26,975 --> 04:14:32,548 MENTAL ILLNESS OR SUBSTANCE ABU. 6843 04:14:32,548 --> 04:14:34,616 I THINK WE HIT ACROSS THE 6844 04:14:34,616 --> 04:14:36,218 PRESENTATIONS AN IMPORTANT 6845 04:14:36,218 --> 04:14:39,555 POINT, THE ABCD STUDDIE IS SO 6846 04:14:39,555 --> 04:14:41,623 RICH IN TERMS OF DATA COLLECTED, 6847 04:14:41,623 --> 04:14:43,158 WE HAVE SUCH A UNIQUE 6848 04:14:43,158 --> 04:14:49,631 OPPORTUNITY TO LOOK AT HOW THESE 6849 04:14:49,631 --> 04:14:50,632 INFLUENCES THAT SHAPED 6850 04:14:50,632 --> 04:14:53,802 INEQUITIES WE SEE TODAY MIGHT 6851 04:14:53,802 --> 04:14:54,203 BRAIN DEVELOPMENT. 6852 04:14:54,203 --> 04:15:00,042 IF WE DON'T DO THAT WE RUN THE 6853 04:15:00,042 --> 04:15:04,980 RISK OF CREATING MODELS OF 6854 04:15:04,980 --> 04:15:06,615 DISEASE AND SUSCEPTIBILITY NOT 6855 04:15:06,615 --> 04:15:07,482 APPLICATION TO POPULATIONS WE 6856 04:15:07,482 --> 04:15:08,617 WANT TO STUDY. 6857 04:15:08,617 --> 04:15:10,552 I'M MOSTLY ON TIME AND WILL PUT 6858 04:15:10,552 --> 04:15:11,620 MY ACKNOWLEDGMENT SLIDE UP AND 6859 04:15:11,620 --> 04:15:12,654 HAPPY TO TAKE QUESTIONS IF 6860 04:15:12,654 --> 04:15:22,898 THERE'S TIME. 6861 04:15:24,900 --> 04:15:26,235 >> THANKS ARE PRESENTATION. 6862 04:15:26,235 --> 04:15:27,636 BEFORE GENERAL DISCUSSION I WANT 6863 04:15:27,636 --> 04:15:29,838 TO GIVE PEOPLE AN OPPORTUNITY TO 6864 04:15:29,838 --> 04:15:30,939 ASK A QUESTION. 6865 04:15:30,939 --> 04:15:33,242 THERE'S ONE THAT I'M TAKING THE 6866 04:15:33,242 --> 04:15:35,744 PREROGATIVE BECAUSE I READ YOUR 6867 04:15:35,744 --> 04:15:36,945 PAPER MANY TIMES. 6868 04:15:36,945 --> 04:15:38,680 IT MAKES MY BRAIN HURT BECAUSE 6869 04:15:38,680 --> 04:15:41,516 ONE OF THE ISSUES IS YOU HAVE 6870 04:15:41,516 --> 04:15:47,456 THE BLACK MATTER OF ALL OF THOSE 6871 04:15:47,456 --> 04:15:48,557 REGIONS, DIFFERENCES BETWEEN 6872 04:15:48,557 --> 04:15:52,160 RACES JUST INCOME AND ECONOMIC 6873 04:15:52,160 --> 04:15:53,462 VARIABLES NOT ACCOUNTING, IT 6874 04:15:53,462 --> 04:15:55,564 HURTS MY BRAIN, THE CHALLENGE TO 6875 04:15:55,564 --> 04:15:56,632 UNDERSTAND VARIABLES WE'RE 6876 04:15:56,632 --> 04:15:57,466 UNABLE TO CAPTURE. 6877 04:15:57,466 --> 04:15:59,401 SO WHAT ARE YOUR THOUGHTS ON 6878 04:15:59,401 --> 04:16:00,068 THAT? 6879 04:16:00,068 --> 04:16:02,237 AND THIS IS LINKED TO THE NOTION 6880 04:16:02,237 --> 04:16:04,973 OF ALL OF THE VARIABLES ARE 6881 04:16:04,973 --> 04:16:06,275 INTERMINGLED IN COMPLEX WAYS 6882 04:16:06,275 --> 04:16:09,011 SUCH AS WHAT WE CAN UNDERSTAND 6883 04:16:09,011 --> 04:16:12,180 FOR EXAMPLE STRESS AND RACE AND 6884 04:16:12,180 --> 04:16:13,482 DISCRIMINATION ACCELERATES 6885 04:16:13,482 --> 04:16:15,083 PUBERTY AND DECREASED LENGTH OF 6886 04:16:15,083 --> 04:16:17,886 TIME FOR THE BRAIN TO 6887 04:16:17,886 --> 04:16:18,220 NEURODEVELOP. 6888 04:16:18,220 --> 04:16:21,156 COULD IT BE FOR EXAMPLE 6889 04:16:21,156 --> 04:16:25,093 STRUCTURAL CHANGES YOU'RE SEEING 6890 04:16:25,093 --> 04:16:26,194 THAT FIGURE IN THE BLACK 6891 04:16:26,194 --> 04:16:28,497 CHILDREN MAY RELATE TO SOME OF 6892 04:16:28,497 --> 04:16:32,034 THOSE PROCESS, HOW TO 6893 04:16:32,034 --> 04:16:33,735 DISENTANGLE COMPLEX INTERACTIONS 6894 04:16:33,735 --> 04:16:37,372 BETWEEN VARIABLES SO WE CAN 6895 04:16:37,372 --> 04:16:38,573 EXTRACT THAT BLACK MATTER. 6896 04:16:38,573 --> 04:16:40,108 >> YOU'RE HITTING THE NAIL ON 6897 04:16:40,108 --> 04:16:41,076 THE HEAD THERE. 6898 04:16:41,076 --> 04:16:44,946 A LOT OF MODELS WE RUN, YEAH, I 6899 04:16:44,946 --> 04:16:47,983 WOULD SAY MAYBE ADVANCED BUT NOT 6900 04:16:47,983 --> 04:16:48,984 REALLY COMPLEX. 6901 04:16:48,984 --> 04:16:50,385 WE'LL LOOK AT UNIQUE 6902 04:16:50,385 --> 04:16:52,020 ASSOCIATIONS WITH INCOME BUT WE 6903 04:16:52,020 --> 04:16:54,389 DON'T LOOK AT, SAY, INCOME BY 6904 04:16:54,389 --> 04:16:56,191 EDUCATION INTERACTIONS. 6905 04:16:56,191 --> 04:16:58,627 I THINK THAT -- THERE WAS A 6906 04:16:58,627 --> 04:17:01,763 GREAT PAPER ON SOME OF THEIR 6907 04:17:01,763 --> 04:17:03,532 PERINATAL IMAGING DATA, SHOWING 6908 04:17:03,532 --> 04:17:04,633 THAT THESE HIGHLY ADVANCED 6909 04:17:04,633 --> 04:17:07,235 MACHINE LEARNING ABLE TO CAPTURE 6910 04:17:07,235 --> 04:17:09,771 MANY TYPES OF INTERACTIONS AMONG 6911 04:17:09,771 --> 04:17:11,173 THESE VARIABLES REPRESENTING 6912 04:17:11,173 --> 04:17:13,909 INEQUITY ARE REALLY IMPORTANT 6913 04:17:13,909 --> 04:17:15,344 FOR EXPLAINING RACE-RELATED 6914 04:17:15,344 --> 04:17:17,312 DIFFERENCES IN BRAIN VOLUME AND 6915 04:17:17,312 --> 04:17:17,979 DEVELOPMENTAL ASPECTS. 6916 04:17:17,979 --> 04:17:20,482 PART OF WHAT WE'LL HAVE TO DO IN 6917 04:17:20,482 --> 04:17:23,218 ORDER TO DISENTANGLE AS YOU'RE 6918 04:17:23,218 --> 04:17:25,721 SAYING IS ACTUALLY GO DOWN THE 6919 04:17:25,721 --> 04:17:26,922 RABBIT HOLE THINKING ABOUT WE'RE 6920 04:17:26,922 --> 04:17:29,024 THINKING ABOUT HOW TO DO THIS IN 6921 04:17:29,024 --> 04:17:33,395 TERMS OF FOR REGIONS THAT MIGHT 6922 04:17:33,395 --> 04:17:34,596 HAVE A PARTICULAR SORT OF 6923 04:17:34,596 --> 04:17:36,365 HISTORICAL INFLUENCE HOW DO WE 6924 04:17:36,365 --> 04:17:37,899 START TO MODEL THE DATA THAT WE 6925 04:17:37,899 --> 04:17:39,501 HAVE FROM THAT. 6926 04:17:39,501 --> 04:17:41,503 I THINK THAT IN REGARDS TO 6927 04:17:41,503 --> 04:17:44,106 DIFFERENCES BETWEEN GRAY MATTER 6928 04:17:44,106 --> 04:17:46,942 VERSUS WHITE MATTER TO ME THAT 6929 04:17:46,942 --> 04:17:49,244 READS THE HYPOTHESIS WOULD BE 6930 04:17:49,244 --> 04:17:52,080 THAT AGAIN THESE TYPES OF 6931 04:17:52,080 --> 04:17:52,948 DIFFERENTIAL EXPOSURES THAT 6932 04:17:52,948 --> 04:17:54,483 PEOPLE HAVE PROMPT DIFFERENT 6933 04:17:54,483 --> 04:17:56,051 TYPES OF EMOTIONAL REGULATION 6934 04:17:56,051 --> 04:17:58,220 AND EMOTIONAL COPING STRATEGIES. 6935 04:17:58,220 --> 04:18:00,188 PART OF THE REASON WE SEE 6936 04:18:00,188 --> 04:18:03,725 DIFFERENCES IS NEED FOR 6937 04:18:03,725 --> 04:18:05,026 EMOTIONAL -- THERE WAS QUITE A 6938 04:18:05,026 --> 04:18:07,095 BIT IN BLACK ADULTS FROM THE 6939 04:18:07,095 --> 04:18:11,133 GRADY TRAUMA PROJECT SHOWING 6940 04:18:11,133 --> 04:18:11,900 DISCRIMINATION POTENTIATES BRAIN 6941 04:18:11,900 --> 04:18:12,901 RESPONSES, YOU SEE RACIAL 6942 04:18:12,901 --> 04:18:17,172 DISCRIMINATION IS ASSOCIATED 6943 04:18:17,172 --> 04:18:18,573 WITH GREATER VMPSC ACTIVITY, 6944 04:18:18,573 --> 04:18:20,575 LOWER ERRORS IN COGNITIVE 6945 04:18:20,575 --> 04:18:22,110 EFFECTIVE TASK THAT SEEMS TO BE 6946 04:18:22,110 --> 04:18:23,979 RELATED TO IN SOME CASES LOWER 6947 04:18:23,979 --> 04:18:24,946 WHITE MATTER VARIABILITY SO I 6948 04:18:24,946 --> 04:18:27,249 THINK THE PROBLEM IS IT'S 6949 04:18:27,249 --> 04:18:29,217 COMPLEX AND WE HAVE TO THINK HOW 6950 04:18:29,217 --> 04:18:31,787 TO MODEL THESE DIFFERENT THINGS. 6951 04:18:31,787 --> 04:18:32,354 >> CONGRATULATIONS. 6952 04:18:32,354 --> 04:18:33,422 IT'S GREAT WORK. 6953 04:18:33,422 --> 04:18:37,125 ANY QUESTIONS HERE? 6954 04:18:37,125 --> 04:18:38,527 BEFORE WE JUMP INTO GENERAL 6955 04:18:38,527 --> 04:18:39,194 DISCUSSIONS. 6956 04:18:39,194 --> 04:18:43,999 I DON'T SEE HANDS RAISED. 6957 04:18:43,999 --> 04:18:45,534 >> I'M REALLY CURIOUS, TO FOLLOW 6958 04:18:45,534 --> 04:18:48,370 UP WHAT NORA SAID, WHAT YOU JUST 6959 04:18:48,370 --> 04:18:52,874 ARE ALLUDING TO, IS THERE ANY 6960 04:18:52,874 --> 04:18:54,309 POSSIBILITY SOME OF THIS CONVEYS 6961 04:18:54,309 --> 04:18:56,978 RESILIENCE, THAT THERE WOULD BE 6962 04:18:56,978 --> 04:19:01,316 A SUBGROUP OF THE AFFLICTED THAT 6963 04:19:01,316 --> 04:19:05,787 ACTUALLY FOR WHATEVER REASON 6964 04:19:05,787 --> 04:19:07,422 HAVE SOME CIRCUITRY THAT HELPS 6965 04:19:07,422 --> 04:19:09,491 THEM DEAL WITH THIS ADVERSITY? 6966 04:19:09,491 --> 04:19:11,460 I'M CURIOUS WHAT YOU THINK OF 6967 04:19:11,460 --> 04:19:11,693 THAT. 6968 04:19:11,693 --> 04:19:13,762 >> YEAH, NO, I AGREE WITH THAT 6969 04:19:13,762 --> 04:19:14,296 COMPLETELY. 6970 04:19:14,296 --> 04:19:16,331 I WOULD TAKE IT A STEP FURTHER, 6971 04:19:16,331 --> 04:19:18,500 I THINK A LOT OF WHAT WE'RE 6972 04:19:18,500 --> 04:19:19,234 SEEING IS RESILIENCE. 6973 04:19:19,234 --> 04:19:21,870 I THINK THERE IS A LITTLE BIT OF 6974 04:19:21,870 --> 04:19:23,839 REACTION TO LOOK AT SORT OF THE 6975 04:19:23,839 --> 04:19:25,907 BRAIN IMAGING FINDINGS AND 6976 04:19:25,907 --> 04:19:27,242 CONCLUDE WHAT EMOTIONAL STATE 6977 04:19:27,242 --> 04:19:31,713 MUST BE BUT ACTUALLY I THINK 6978 04:19:31,713 --> 04:19:33,682 THAT TO BORROW ANALOGY, WHEN 6979 04:19:33,682 --> 04:19:34,783 YOU'RE CONSTANTLY EXPOSED TO 6980 04:19:34,783 --> 04:19:40,589 THESE STRESSORS YOU STILL HAVE 6981 04:19:40,589 --> 04:19:42,791 TO GO THROUGH LIFE, GO TO WORK, 6982 04:19:42,791 --> 04:19:44,326 THEY ARE STILL ABLE TO DO THAT, 6983 04:19:44,326 --> 04:19:44,526 RIGHT? 6984 04:19:44,526 --> 04:19:48,029 IT'S SOMETHING THEY ARE ABLE TO 6985 04:19:48,029 --> 04:19:48,363 DO. 6986 04:19:48,363 --> 04:19:50,432 IN SOME WAYS MAYBE WE'RE LOOKING 6987 04:19:50,432 --> 04:19:53,068 AT DIFFERENT NEURAL PROFILES OF 6988 04:19:53,068 --> 04:19:54,035 RESILIENCE OR NEUROADAPTABILITY. 6989 04:19:54,035 --> 04:19:55,537 IT MAY BE THE CASE THERE'S NO 6990 04:19:55,537 --> 04:19:56,905 SUCH THING AS A FREE LUNCH, 6991 04:19:56,905 --> 04:19:58,807 MIGHT BE OTHER CASES SUCH AS THE 6992 04:19:58,807 --> 04:20:00,075 WORK THAT DR. ADAMS WAS 6993 04:20:00,075 --> 04:20:02,377 PRESENTING WHERE THIS MIGHT HAVE 6994 04:20:02,377 --> 04:20:03,044 SORT OF DETRIMENTAL IMPACTS 6995 04:20:03,044 --> 04:20:04,946 WHILE TRYING TO HAVE PROTECTIVE 6996 04:20:04,946 --> 04:20:06,014 IMPACTS IN OTHER AREAS. 6997 04:20:06,014 --> 04:20:09,017 YEAH, I AGREE WITH THAT. 6998 04:20:09,017 --> 04:20:11,753 >> THERE'S ONE LAST QUESTION. 6999 04:20:11,753 --> 04:20:12,153 TRISH? 7000 04:20:12,153 --> 04:20:12,621 >> THANKS. 7001 04:20:12,621 --> 04:20:16,091 SO, IT BUILDS ON NORA'S QUESTION 7002 04:20:16,091 --> 04:20:16,691 FROM THE OPPOSITE DIRECTION. 7003 04:20:16,691 --> 04:20:21,930 DO YOU HAVE CHILDREN WHO ARE NOT 7004 04:20:21,930 --> 04:20:23,532 OF MINORITIZED POPULATIONS WHO 7005 04:20:23,532 --> 04:20:24,766 HAVE THESE ADVERSITIES, THAT YOU 7006 04:20:24,766 --> 04:20:30,872 CAN LOOK DOWN THAT LIST AND SAY, 7007 04:20:30,872 --> 04:20:34,376 THE ADVERSITIES CORRELATE IN 7008 04:20:34,376 --> 04:20:35,176 BRAIN VOLUME, DISENTANGLING, 7009 04:20:35,176 --> 04:20:36,678 KNOWING YOUR MISSING SOMETHING 7010 04:20:36,678 --> 04:20:41,182 IF THEY DON'T LOOK THE SAME, AND 7011 04:20:41,182 --> 04:20:44,886 MAYBE REINFORCERS ACROSS LIFE OF 7012 04:20:44,886 --> 04:20:45,987 DISCRIMINATION, RACISM, OR ARE 7013 04:20:45,987 --> 04:20:49,057 THESE FACTORS ENOUGH TO GIVE 7014 04:20:49,057 --> 04:20:50,692 DIFFERENCES IN BRAIN VOLUME, ET 7015 04:20:50,692 --> 04:20:51,026 CETERA? 7016 04:20:51,026 --> 04:20:53,428 >> YEAH, I THINK I GOT THAT 7017 04:20:53,428 --> 04:20:54,529 QUESTION. 7018 04:20:54,529 --> 04:20:57,532 IF I ANSWER INCORRECTLY JUMP IN. 7019 04:20:57,532 --> 04:21:01,536 WE DO TRY TO LOOK AT THE 7020 04:21:01,536 --> 04:21:04,372 INDIVIDUAL PREDICTORS BY 7021 04:21:04,372 --> 04:21:06,107 THEMSELVES WITHOUT JUST 7022 04:21:06,107 --> 04:21:06,841 ACCOUNTING RACE-RELATED 7023 04:21:06,841 --> 04:21:07,842 DIFFERENCES BECAUSE WE WANT TO 7024 04:21:07,842 --> 04:21:11,813 SEE IF JUST USING THEM ALONE, 7025 04:21:11,813 --> 04:21:12,881 THOSE PREDICTING VARIANTS, OFTEN 7026 04:21:12,881 --> 04:21:17,052 WE FIND RACE IS STILL A MORE 7027 04:21:17,052 --> 04:21:17,919 SIGNIFICANT PREDICTOR THAN JUST 7028 04:21:17,919 --> 04:21:18,853 USING INDIVIDUAL FACTORS. 7029 04:21:18,853 --> 04:21:20,322 THAT GOES BACK TO THE WIDER 7030 04:21:20,322 --> 04:21:21,990 POINT RACE IS NOT JUST SKIN 7031 04:21:21,990 --> 04:21:22,624 COLOR. 7032 04:21:22,624 --> 04:21:24,826 IT'S THESE THINGS WE'VE LOOKED 7033 04:21:24,826 --> 04:21:26,027 AT PLUS THE INTERACTING FACTORS 7034 04:21:26,027 --> 04:21:27,862 PLUS A LOT OF PROBABLY 7035 04:21:27,862 --> 04:21:28,964 UNMEASURED THINGS WE'RE NOT ABLE 7036 04:21:28,964 --> 04:21:31,366 TO DO EVEN WITH ABCD, HAVEN'T 7037 04:21:31,366 --> 04:21:33,835 THOUGHT ABOUT HOW TO CORRECTLY 7038 04:21:33,835 --> 04:21:35,537 DO YET. 7039 04:21:35,537 --> 04:21:37,839 I THINK THAT TO DELVE FURTHER, I 7040 04:21:37,839 --> 04:21:40,575 WANT TO BE CLEAR THAT I'M NOT 7041 04:21:40,575 --> 04:21:42,077 SAYING THAT PEOPLE FROM 7042 04:21:42,077 --> 04:21:43,311 DIFFERENT GROUPS ARE NOT EXPOSED 7043 04:21:43,311 --> 04:21:44,646 TO DIFFERENT TYPES OF STRESSORS 7044 04:21:44,646 --> 04:21:46,314 LIKE POVERTY OR TRAUMA OR THINGS 7045 04:21:46,314 --> 04:21:47,515 LIKE THIS. 7046 04:21:47,515 --> 04:21:52,320 I THINK THAT WHAT MY POINT IS 7047 04:21:52,320 --> 04:21:53,622 THAT INEQUITIES THAT EXIST ARE 7048 04:21:53,622 --> 04:21:54,923 VERY PRESENT AND VERY 7049 04:21:54,923 --> 04:21:56,591 OBSERVABLE, AND SO TRYING TO 7050 04:21:56,591 --> 04:21:58,326 THINK ABOUT WHEN WE DO WANT TO 7051 04:21:58,326 --> 04:22:03,231 TALK ABOUT THE IMPACTS OF 7052 04:22:03,231 --> 04:22:12,874 POVERTY, IMPACTS OF VIOLENCE, 7053 04:22:12,874 --> 04:22:13,875 CONTEXTUALIZING THERE'S A 7054 04:22:13,875 --> 04:22:14,376 DISPROPORTION EXPOSURE. 7055 04:22:14,376 --> 04:22:15,210 >> GREAT TALK. 7056 04:22:15,210 --> 04:22:17,612 ALL THE TALKS WERE OUTSTANDING. 7057 04:22:17,612 --> 04:22:21,216 WE HAVE OPEN DISCUSSION UNTIL 7058 04:22:21,216 --> 04:22:21,416 3:45. 7059 04:22:21,416 --> 04:22:24,285 AND THEN WE'RE GOING TO ADJOURN. 7060 04:22:24,285 --> 04:22:26,588 I GET TO ADJOURN US. 7061 04:22:26,588 --> 04:22:33,695 SO, I WAS GOING FIRST ASK THE 7062 04:22:33,695 --> 04:22:35,230 ONLINE PARTICIPANTS BECAUSE 7063 04:22:35,230 --> 04:22:38,633 WE'VE NEGLECTED YOU, WHETHER YOU 7064 04:22:38,633 --> 04:22:43,438 HAVE ANY QUESTIONS FOR ANY ONE 7065 04:22:43,438 --> 04:22:45,407 OF THE SPEAKERS, ANY OF THE 7066 04:22:45,407 --> 04:22:47,475 ITEMS THAT CAME UP TODAY, WHAT 7067 04:22:47,475 --> 04:22:53,515 WE COVERED, QUESTIONS FOR ABCD 7068 04:22:53,515 --> 04:23:03,892 OR HBCD, ANY -- OKAY. 7069 04:23:04,192 --> 04:23:04,993 GO AHEAD. 7070 04:23:04,993 --> 04:23:07,395 >> MARK, GO AHEAD. 7071 04:23:07,395 --> 04:23:09,698 >> OH, THANK YOU, GEORGE. 7072 04:23:09,698 --> 04:23:15,537 I WANTED TO SAY THIS HAS BEEN AN 7073 04:23:15,537 --> 04:23:17,439 IMPRESSIVE SESSION, AND IT'S 7074 04:23:17,439 --> 04:23:23,678 SORT OF EXPANDED MY BRAIN FROM 7075 04:23:23,678 --> 04:23:31,052 MY NARROW FOCUS, FROM THE THINGS 7076 04:23:31,052 --> 04:23:33,221 WE PARTICULARLY WORK ON. 7077 04:23:33,221 --> 04:23:37,258 I'VE HAD THIS THOUGHT, IT'S NOT 7078 04:23:37,258 --> 04:23:39,227 ATTACHED TO A SINGLE 7079 04:23:39,227 --> 04:23:41,062 PRESENTATION, THERE HAVE BEEN A 7080 04:23:41,062 --> 04:23:42,497 NUMBER THAT HAVE BROUGHT UP THIS 7081 04:23:42,497 --> 04:23:45,366 THOUGHT FOR ME. 7082 04:23:45,366 --> 04:23:49,637 I'M THINKING ABOUT THE AMOUNT OF 7083 04:23:49,637 --> 04:23:52,707 DATA THAT FOLKS HAVE BEEN ABLE 7084 04:23:52,707 --> 04:23:55,110 TO COLLECT, THE RICHNESS OF THE 7085 04:23:55,110 --> 04:23:56,945 DATA IS REALLY PRETTY EXCITING, 7086 04:23:56,945 --> 04:23:58,913 AND I WONDER IF IT WOULD MAKE 7087 04:23:58,913 --> 04:24:01,116 SENSE, AND I DON'T KNOW IF THIS 7088 04:24:01,116 --> 04:24:01,850 IS STATISTICALLY POSSIBLE, 7089 04:24:01,850 --> 04:24:03,118 BECAUSE I DON'T REALLY HAVE A 7090 04:24:03,118 --> 04:24:07,122 FEELING FOR HOW MUCH DATA THERE 7091 04:24:07,122 --> 04:24:11,092 IS, BUT WOULD IT BE WORTH 7092 04:24:11,092 --> 04:24:12,260 CONSIDERING AND MAYBE PEOPLE ARE 7093 04:24:12,260 --> 04:24:14,162 DOING THIS AND I COULD HAVE 7094 04:24:14,162 --> 04:24:16,030 MISSED THIS, TAKING UNBIASED 7095 04:24:16,030 --> 04:24:18,633 SORT OF CLUSTERING AND DATA 7096 04:24:18,633 --> 04:24:22,804 REDUCTION STRATEGIES, SO RATHER 7097 04:24:22,804 --> 04:24:25,206 THAN HYPOTHESIS-DRIVEN QUESTIONS 7098 04:24:25,206 --> 04:24:27,175 BUT ACTUALLY ASKING ABOUT DO 7099 04:24:27,175 --> 04:24:29,043 THESE THINGS CLUSTER IN SOME 7100 04:24:29,043 --> 04:24:32,413 UNBIASED WAY, THINKING ABOUT THE 7101 04:24:32,413 --> 04:24:38,486 METHODS THAT HAVE BEEN SORT OF 7102 04:24:38,486 --> 04:24:41,723 PIONEERED AND REALLY VALIDATED 7103 04:24:41,723 --> 04:24:43,591 FOR GENOME EXPRESSION, FOR 7104 04:24:43,591 --> 04:24:45,560 TRANSCRIPT EXPRESSION, AND FOR 7105 04:24:45,560 --> 04:24:46,995 GENE CLUSTERING STUDIES REALLY. 7106 04:24:46,995 --> 04:24:49,631 SO I'M WONDERING IF ANY OF THAT 7107 04:24:49,631 --> 04:24:51,666 UNBIASED LIKE CLUSTERING STUFF 7108 04:24:51,666 --> 04:24:54,202 MIGHT BE USEFUL FOR EXAMPLE IN 7109 04:24:54,202 --> 04:24:56,237 THESE BRAIN MEASUREMENTS OR 7110 04:24:56,237 --> 04:24:59,240 PERHAPS MANY OF THE BEHAVIORAL 7111 04:24:59,240 --> 04:25:02,043 MEASURES THAT HAVE BEEN SO 7112 04:25:02,043 --> 04:25:04,512 ELEGANTLY DESCRIBED. 7113 04:25:04,512 --> 04:25:05,280 THANK YOU. 7114 04:25:05,280 --> 04:25:07,582 >> MARK, I'M GOING TO ASK GAYA 7115 04:25:07,582 --> 04:25:08,449 TO RESPOND. 7116 04:25:08,449 --> 04:25:10,418 WHILE SHE'S FINDING A MICROPHONE 7117 04:25:10,418 --> 04:25:12,287 I'M GOING TO MENTION THAT IN A 7118 04:25:12,287 --> 04:25:16,124 SMALL SUBAREA THAT I WORK IN, 7119 04:25:16,124 --> 04:25:17,859 WE'VE BEEN DOING PHARMACO 7120 04:25:17,859 --> 04:25:19,494 EPIDEMIOLOGICAL STUDIES. 7121 04:25:19,494 --> 04:25:23,998 WE ACTUALLY TAKE HUGE COHORTS 7122 04:25:23,998 --> 04:25:29,037 AND FIND OUT WHETHER SPIRALACTON 7123 04:25:29,037 --> 04:25:30,672 IS CORRELATED WITH DECREASES IN 7124 04:25:30,672 --> 04:25:34,375 DRINKING EVEN THOUGH IT'S USED 7125 04:25:34,375 --> 04:25:36,644 FOR TREATING HYPERTENSION, I 7126 04:25:36,644 --> 04:25:37,979 THINK. 7127 04:25:37,979 --> 04:25:38,980 I THINK THERE'S THIS BEGINNING 7128 04:25:38,980 --> 04:25:43,551 OF A SPEED THERE, EVEN IN 7129 04:25:43,551 --> 04:25:50,024 PHARMACO EPIDEMIOLOGY, WHAT 7130 04:25:50,024 --> 04:25:51,659 YOU'RE TALKING ABOUT. 7131 04:25:51,659 --> 04:25:53,394 >> A COUPLE PAYMENTS HAVE 7132 04:25:53,394 --> 04:25:56,264 CLUSTERING ANALYSIS, IDENTIFIED 7133 04:25:56,264 --> 04:26:03,071 GROUPS OF VARIABLES THAT SHOWED 7134 04:26:03,071 --> 04:26:03,805 DISTINCT PHENOTYPES. 7135 04:26:03,805 --> 04:26:05,240 THAT'S SOMETHING THAT IS GOING 7136 04:26:05,240 --> 04:26:06,875 ON IN THE FIELD. 7137 04:26:06,875 --> 04:26:08,409 HAPPY TO SHARE, I DON'T HAVE 7138 04:26:08,409 --> 04:26:11,246 DETAILS OFF THE TOP OF MY HEAD. 7139 04:26:11,246 --> 04:26:13,448 >> NANCY BARNETT HAS A QUESTION? 7140 04:26:13,448 --> 04:26:14,549 >> THANK YOU. 7141 04:26:14,549 --> 04:26:17,719 I DIDN'T FEEL IGNORED, GEORGE. 7142 04:26:17,719 --> 04:26:19,687 IT WAS A FANTASTIC SET OF TALKS 7143 04:26:19,687 --> 04:26:20,889 TODAY THAT HIGHLIGHTS COMMITMENT 7144 04:26:20,889 --> 04:26:23,524 TO AND BENEFIT OF THESE LARGE 7145 04:26:23,524 --> 04:26:28,129 SCALE LONGITUDINAL STUDIES. 7146 04:26:28,129 --> 04:26:28,763 I LEARNED A LOT. 7147 04:26:28,763 --> 04:26:31,199 MY QUESTION IS A VERY BROAD ONE, 7148 04:26:31,199 --> 04:26:32,634 I HOPE IT'S APPROPRIATE TO BRING 7149 04:26:32,634 --> 04:26:34,035 UP HERE. 7150 04:26:34,035 --> 04:26:35,570 THERE HAVE BEEN HISTORICAL 7151 04:26:35,570 --> 04:26:36,638 CIRCUMSTANCES THAT HAVE 7152 04:26:36,638 --> 04:26:38,206 HAPPENED, YOU KNOW, OF LATE, THE 7153 04:26:38,206 --> 04:26:39,173 PANDEMIC BEING A MAJOR RECENT 7154 04:26:39,173 --> 04:26:40,909 ONE WHERE WE'VE SEEN CLEAR 7155 04:26:40,909 --> 04:26:43,344 EFFECTS ON SUBSTANCE USE, MENTAL 7156 04:26:43,344 --> 04:26:46,748 HEALTH, SOCIAL HEALTH, ET 7157 04:26:46,748 --> 04:26:47,148 CETERA. 7158 04:26:47,148 --> 04:26:49,250 AND I'M WONDERING TO THE EXTENT 7159 04:26:49,250 --> 04:26:51,886 THAT WE CAN WOULD THIS BE THE 7160 04:26:51,886 --> 04:26:56,491 CORRECT VENUE TO RAISE THE ISSUE 7161 04:26:56,491 --> 04:26:58,226 OF ANTICIPATING RESCHEDULING OF 7162 04:26:58,226 --> 04:26:58,493 CANNABIS? 7163 04:26:58,493 --> 04:27:03,598 ARE WE ABLE TO THINK ABOUT THAT 7164 04:27:03,598 --> 04:27:05,633 AS -- I HAVE FURTHER QUESTIONS. 7165 04:27:05,633 --> 04:27:10,071 >> I'LL GIVE THAT ONE TO NORA. 7166 04:27:10,071 --> 04:27:11,806 >> WELL, I'VE BEEN TOLD, I COULD 7167 04:27:11,806 --> 04:27:14,909 NOT COMMENT ON RESCHEDULING 7168 04:27:14,909 --> 04:27:20,348 ITSELF BUT WHAT I CAN TELL YOU 7169 04:27:20,348 --> 04:27:24,285 THAT MARIJUANA AS SCALE 1 HAS 7170 04:27:24,285 --> 04:27:26,721 JEOPARDIZED RESEARCH AT SO MANY 7171 04:27:26,721 --> 04:27:31,859 LEVELS, CLARIFYING SCALING 7172 04:27:31,859 --> 04:27:34,162 DOESN'T MEAN LEGALIZING OR 7173 04:27:34,162 --> 04:27:36,564 CRIMINALIZING BUT WOULD ALLOW 7174 04:27:36,564 --> 04:27:37,999 RESEARCH, I CANNOT COMMENT 7175 04:27:37,999 --> 04:27:39,300 EXCEPT I'VE BEEN VERY EXPLICIT 7176 04:27:39,300 --> 04:27:41,936 ABOUT THE FACT THAT HAVING 7177 04:27:41,936 --> 04:27:43,905 MARIJUANA AS A SCALE 1 HAS BEEN 7178 04:27:43,905 --> 04:27:46,641 A DETERRENT FOR ADVANCING 7179 04:27:46,641 --> 04:27:46,908 RESEARCH. 7180 04:27:46,908 --> 04:27:47,542 >> THANK YOU. 7181 04:27:47,542 --> 04:27:49,610 THAT'S KIND OF -- I WASN'T 7182 04:27:49,610 --> 04:27:51,145 REALLY THINKING THERE WOULD BE 7183 04:27:51,145 --> 04:27:52,981 COMMENTARY ON WHETHER OR NOT IT 7184 04:27:52,981 --> 04:27:53,982 WILL HAPPEN BUT JUST 7185 04:27:53,982 --> 04:27:56,918 ANTICIPATING THAT IT VERY WELL 7186 04:27:56,918 --> 04:27:57,452 COULD HAPPEN. 7187 04:27:57,452 --> 04:28:00,321 IN EXPECT IT WOULD MAKE RESEARCH 7188 04:28:00,321 --> 04:28:01,622 LESS RESTRICTED, THAT COULD 7189 04:28:01,622 --> 04:28:03,391 SPEED UP THE INFORMATION ABOUT 7190 04:28:03,391 --> 04:28:06,094 SO MUCH FROM CANNABIS EFFECTS ON 7191 04:28:06,094 --> 04:28:07,962 THE BRAIN TO DETECTION AND 7192 04:28:07,962 --> 04:28:08,763 MEASUREMENT OF DRIVING 7193 04:28:08,763 --> 04:28:09,831 IMPAIRMENT WILL ALLOW FOR 7194 04:28:09,831 --> 04:28:11,933 IMPROVED RESEARCH ON MEDICAL 7195 04:28:11,933 --> 04:28:12,467 USE. 7196 04:28:12,467 --> 04:28:14,569 WHAT DO YOU THINK IT WILL HAVE, 7197 04:28:14,569 --> 04:28:18,239 WHAT EFFECT IN TERMS OF 7198 04:28:18,239 --> 04:28:20,775 PREVENTION AND INTERVENTION 7199 04:28:20,775 --> 04:28:22,510 IMPLICATIONS, SHOULD HAVE 7200 04:28:22,510 --> 04:28:23,978 IMPLICATIONS FOR CO-USE WITH 7201 04:28:23,978 --> 04:28:25,046 ALCOHOL AND TOBACCO, RELEVANT 7202 04:28:25,046 --> 04:28:25,680 FOR CRAN. 7203 04:28:25,680 --> 04:28:27,115 I WONDER IF THERE ARE THOUGHTS 7204 04:28:27,115 --> 04:28:28,883 IN THE AUDIENCE ABOUT WHAT WE 7205 04:28:28,883 --> 04:28:30,318 MIGHT ANTICIPATE AND WHAT WE 7206 04:28:30,318 --> 04:28:32,720 MIGHT WANT TO PLAN TO RESEARCH. 7207 04:28:32,720 --> 04:28:34,355 >> I THINK IT IS AN EXTREMELY 7208 04:28:34,355 --> 04:28:37,892 IMPORTANT QUESTION THAT WE WILL 7209 04:28:37,892 --> 04:28:40,161 NEED TO FIND OUT THERE'S A 7210 04:28:40,161 --> 04:28:41,829 SCALING AND IMPORTANTLY HOW THAT 7211 04:28:41,829 --> 04:28:43,765 SCALING MAY HAVE A CASCADE 7212 04:28:43,765 --> 04:28:46,200 EFFECT IN THE PATTERNS OF 7213 04:28:46,200 --> 04:28:48,603 MEDICAL CANNABIS AND 7214 04:28:48,603 --> 04:28:53,975 RECREATIONAL CANNABIS AND PEOPLE 7215 04:28:53,975 --> 04:28:55,510 ARE EQUATING SAYING WE'RE 7216 04:28:55,510 --> 04:28:56,811 LEGALIZING CANNABIS IN OUR 7217 04:28:56,811 --> 04:28:57,045 COUNTRY. 7218 04:28:57,045 --> 04:28:58,112 ABSOLUTELY NOT. 7219 04:28:58,112 --> 04:29:00,648 ONE OF THE ISSUES THAT IS TO ME 7220 04:29:00,648 --> 04:29:05,787 COULD BE VERY IMPORTANT IS 7221 04:29:05,787 --> 04:29:08,523 EXTENT TO WHICH THEY ARE MORE 7222 04:29:08,523 --> 04:29:09,624 WELL ORGANIZED, REGULATION OF 7223 04:29:09,624 --> 04:29:12,260 THE PRODUCTS GOING OUT THERE. 7224 04:29:12,260 --> 04:29:13,795 WHICH RIGHT NOW IS BASICALLY THE 7225 04:29:13,795 --> 04:29:18,032 WILD WEST, SOME STATES HAVE MORE 7226 04:29:18,032 --> 04:29:19,934 OR LESS REGULATION. 7227 04:29:19,934 --> 04:29:22,336 THAT PUTS DIFFERENT LEVELS OF 7228 04:29:22,336 --> 04:29:22,537 RISK. 7229 04:29:22,537 --> 04:29:25,273 I WOULD SEE ONE OR LESS EFFECTS. 7230 04:29:25,273 --> 04:29:28,676 I DO HOPE SCALING WILL MAKE IT 7231 04:29:28,676 --> 04:29:30,745 MUCH EASIER FOR RESEARCHERS TO 7232 04:29:30,745 --> 04:29:32,513 WORK INTO THESE FIELDS AT 7233 04:29:32,513 --> 04:29:34,916 MULTIPLE LEVELS, THAT'S ALL I'M 7234 04:29:34,916 --> 04:29:35,783 GOING TO SAY. 7235 04:29:35,783 --> 04:29:38,419 I WANT TO HEAR OTHER COMMENTS 7236 04:29:38,419 --> 04:29:43,558 AND QUESTIONS. 7237 04:29:43,558 --> 04:29:45,293 7238 04:29:45,293 --> 04:29:47,161 >> SO THANK YOU, NANCY. 7239 04:29:47,161 --> 04:29:50,598 I ADMIRE YOUR WILLINGNESS TO ASK 7240 04:29:50,598 --> 04:29:52,200 A QUESTION THAT'S NOT ONE 7241 04:29:52,200 --> 04:29:53,601 STANDARD ONE WE WERE TALKING 7242 04:29:53,601 --> 04:29:53,835 ABOUT. 7243 04:29:53,835 --> 04:29:55,403 SO I URGE THE REST OF YOU THE 7244 04:29:55,403 --> 04:29:56,237 SAME THING. 7245 04:29:56,237 --> 04:30:00,408 IF YOU HAVE OTHER QUESTIONS FOR 7246 04:30:00,408 --> 04:30:05,513 ANY OF US. 7247 04:30:05,513 --> 04:30:09,817 HOWARD?? 7248 04:30:09,817 --> 04:30:14,088 >> CAN YOU START MY VIDEO? 7249 04:30:14,088 --> 04:30:15,156 >> SOMEONE HAS TO, YES. 7250 04:30:15,156 --> 04:30:17,091 I DON'T KNOW, BECAUSE SOMETIMES 7251 04:30:17,091 --> 04:30:24,565 IT IS -- 7252 04:30:24,565 --> 04:30:26,200 >> I'LL START MY QUESTION TO 7253 04:30:26,200 --> 04:30:26,767 MICAH. 7254 04:30:26,767 --> 04:30:31,239 THANK YOU FOR THE PRESENTATION 7255 04:30:31,239 --> 04:30:36,744 ABOUT THE START. 7256 04:30:36,744 --> 04:30:41,616 I'M INTRIGUED BY THE FOCUS ON 7257 04:30:41,616 --> 04:30:45,319 UNMET NEED INDICATIONS IN 7258 04:30:45,319 --> 04:30:47,555 POPULATIONS, HOW FROM MY 7259 04:30:47,555 --> 04:30:50,591 PERSPECTIVE WORKING IN GLOBAL 7260 04:30:50,591 --> 04:30:53,461 INDUSTRY, HOW THERE ARE BOTH 7261 04:30:53,461 --> 04:30:55,429 REGULATORY OTHER ORGANIZATIONS, 7262 04:30:55,429 --> 04:30:58,266 BOTH PUBLIC AND PRIVATE, ALSO 7263 04:30:58,266 --> 04:31:01,302 TRYING TO ADDRESS THESE ISSUES. 7264 04:31:01,302 --> 04:31:04,472 NOT ALWAYS IN ABCD KIND OF GOALS 7265 04:31:04,472 --> 04:31:09,076 BUT JUST, YOU KNOW, IN TERMS OF 7266 04:31:09,076 --> 04:31:14,248 DEVELOPING WORKFORCE AND PROPER 7267 04:31:14,248 --> 04:31:16,551 RESEARCH, I'M WONDERING IF 7268 04:31:16,551 --> 04:31:18,953 YOU'VE CONSIDERED HOW TO NETWORK 7269 04:31:18,953 --> 04:31:22,890 WITH THOSE, IS MY VIDEO ON? 7270 04:31:22,890 --> 04:31:23,224 OKAY. 7271 04:31:23,224 --> 04:31:26,527 AND BY THE WAY I HAPPEN TO BE 7272 04:31:26,527 --> 04:31:29,497 WEARING MY START SHIRT TODAY, 7273 04:31:29,497 --> 04:31:32,200 BEING A GRADUATE OF ANOTHER 7274 04:31:32,200 --> 04:31:33,734 START PROGRAM THAT HAS BEEN 7275 04:31:33,734 --> 04:31:38,005 GOING ON IN EUROPE. 7276 04:31:38,005 --> 04:31:40,074 EUROPEANS HAD SOMETHING CALLED 7277 04:31:40,074 --> 04:31:41,609 THE STARS INITIATIVE, AGAIN, 7278 04:31:41,609 --> 04:31:46,647 TRYING TO ADDRESS THE SAME TYPE 7279 04:31:46,647 --> 04:31:49,817 OF PROGRAM FOR DEVELOPMENT IN 7280 04:31:49,817 --> 04:31:51,018 UNMET NEED INDICATIONS OF 7281 04:31:51,018 --> 04:31:54,522 VARIOUS TYPES, NEUROLOGIC AS 7282 04:31:54,522 --> 04:31:56,724 WELL AS ONCOLOGIC. 7283 04:31:56,724 --> 04:31:58,025 BUT THAT'S A QUESTION, BECAUSE, 7284 04:31:58,025 --> 04:32:02,396 YOU KNOW, I SEE THE GOALS YOU 7285 04:32:02,396 --> 04:32:04,165 HAVE, MIGHT BESTING SERVED, 7286 04:32:04,165 --> 04:32:07,668 LONG-TERM GOALS, BY MY 7287 04:32:07,668 --> 04:32:10,371 COLLABORATIVE WORK IN LEARNING 7288 04:32:10,371 --> 04:32:10,738 ACROSS BORDERS. 7289 04:32:10,738 --> 04:32:12,340 >> YES, THANK YOU FOR THAT 7290 04:32:12,340 --> 04:32:12,607 QUESTION. 7291 04:32:12,607 --> 04:32:14,475 I JUST WANT TO SAY START IS 7292 04:32:14,475 --> 04:32:16,744 GOING GLOBAL SO THANK YOU. 7293 04:32:16,744 --> 04:32:17,945 WE HAVE SITES EVERYWHERE. 7294 04:32:17,945 --> 04:32:22,516 THAT SHIRT WILL BE USEFUL. 7295 04:32:22,516 --> 04:32:23,651 I THINK YOU'RE SPOT ON. 7296 04:32:23,651 --> 04:32:25,186 I THINK THAT'S THE FUTURE. 7297 04:32:25,186 --> 04:32:27,021 THE FUTURE IS THESE 7298 04:32:27,021 --> 04:32:28,689 COLLABORATIONS, NOT JUST ACROSS 7299 04:32:28,689 --> 04:32:30,324 FIELDS IN RESEARCH BUT ACROSS 7300 04:32:30,324 --> 04:32:32,860 THE INDUSTRIES, HOW DO WE TACKLE 7301 04:32:32,860 --> 04:32:34,061 THIS ISSUE OF WORKFORCE 7302 04:32:34,061 --> 04:32:36,664 DEVELOPMENT BUT ALSO MAKING SURE 7303 04:32:36,664 --> 04:32:37,765 SOCIAL IMPEDIMENTS DON'T PREVENT 7304 04:32:37,765 --> 04:32:41,269 TALENT FROM BEING ABLE TO 7305 04:32:41,269 --> 04:32:41,569 FLOURISH. 7306 04:32:41,569 --> 04:32:42,803 AGAIN, WE'RE STILL PRETTY EARLY 7307 04:32:42,803 --> 04:32:44,672 IN THE PROCESS BUT RIGHT NOW 7308 04:32:44,672 --> 04:32:47,275 WHAT WE DO IS STUDY FOLKS WHO DO 7309 04:32:47,275 --> 04:32:48,376 IT WELL. 7310 04:32:48,376 --> 04:32:50,144 SOME RECRUITMENT STRATEGIES, A 7311 04:32:50,144 --> 04:32:51,445 GREAT QUESTION EARLIER, WE'VE 7312 04:32:51,445 --> 04:32:53,648 ADOPTED BASED ON WHO DOES THIS 7313 04:32:53,648 --> 04:32:55,616 VERY WELL, WHERE ARE FOLKS WHO 7314 04:32:55,616 --> 04:32:57,151 HAVE THE BEST TALENT, WHO SEEM 7315 04:32:57,151 --> 04:32:59,587 TO HAVE OVERCOME THESE BARRIERS, 7316 04:32:59,587 --> 04:33:00,354 SOCIAL HISTORICAL BARRIERS, WE 7317 04:33:00,354 --> 04:33:02,523 STUDY FOLKS WHO DO IT WELL AND 7318 04:33:02,523 --> 04:33:03,824 EVENTUALLY WHAT WE WANT TO DO IS 7319 04:33:03,824 --> 04:33:05,593 JUST THAT. 7320 04:33:05,593 --> 04:33:07,228 SEE IF WE CAN REPLICATE THESE 7321 04:33:07,228 --> 04:33:08,763 BEST PRACTICES AND THESE 7322 04:33:08,763 --> 04:33:10,298 APPROACHES IN DIFFERENT SPACES 7323 04:33:10,298 --> 04:33:11,832 BUT THEN BEGIN TO COLLABORATE 7324 04:33:11,832 --> 04:33:12,800 WITH DIFFERENT INDUSTRIES ABOUT 7325 04:33:12,800 --> 04:33:15,770 HOW DO WE BEGIN TO ALSO APPLY 7326 04:33:15,770 --> 04:33:19,273 THESE SAME TOOLS AND TECHNIQUES 7327 04:33:19,273 --> 04:33:24,512 TO ACHIEVE THEIR GOALS IN THEIR 7328 04:33:24,512 --> 04:33:26,380 RESPECTIVE FIELDS. 7329 04:33:26,380 --> 04:33:29,417 >> WE CAN TALK MORE OFFLINE, 7330 04:33:29,417 --> 04:33:30,851 I'LL SHARE EXAMPLES I LIVED 7331 04:33:30,851 --> 04:33:32,386 THROUGH AND WORK WITH IN 7332 04:33:32,386 --> 04:33:34,555 DIFFERENT ORGANIZATIONS LIKE THE 7333 04:33:34,555 --> 04:33:35,756 STARS CONSORTIUM WHICH YOU CAN 7334 04:33:35,756 --> 04:33:40,361 LOOK UP OP LINE, I CAN EXPLAIN 7335 04:33:40,361 --> 04:33:41,662 THE BACKGROUND, EUROPEAN GROUP 7336 04:33:41,662 --> 04:33:43,497 18 REGULATORY AUTHORITIES TO TRY 7337 04:33:43,497 --> 04:33:45,499 AND DEVELOP WORKFORCE OUT OF 7338 04:33:45,499 --> 04:33:47,034 ACADEMIA, WHAT YOU'VE BEEN 7339 04:33:47,034 --> 04:33:48,502 DOING, TAKING PEOPLE FROM 7340 04:33:48,502 --> 04:33:49,670 ACADEMIA AND GIVING THEM THE 7341 04:33:49,670 --> 04:33:54,909 RIGHT KIND OF LET'S SAY 7342 04:33:54,909 --> 04:33:58,646 REGULATORY SCIENCE ENABLEMENT TO 7343 04:33:58,646 --> 04:34:00,815 MOVE FORWARD IN DEVELOPING NEW 7344 04:34:00,815 --> 04:34:02,783 TREATMENTS ARE FOR UNMET NEED 7345 04:34:02,783 --> 04:34:03,084 INDICATIONS. 7346 04:34:03,084 --> 04:34:03,451 >> EXCELLENT. 7347 04:34:03,451 --> 04:34:05,553 THANK YOU. 7348 04:34:05,553 --> 04:34:08,055 LET'S CHAT. 7349 04:34:08,055 --> 04:34:09,090 MICAH JOHNSON. 7350 04:34:09,090 --> 04:34:10,124 >> MICAH SAID THAT HE'S HAPPY TO 7351 04:34:10,124 --> 04:34:11,659 CHAT WITH YOU. 7352 04:34:11,659 --> 04:34:14,295 MAYBE YOU CAN CONNECT BY E-MAIL 7353 04:34:14,295 --> 04:34:19,767 OR TEXT OR SOMETHING LIKE THAT. 7354 04:34:19,767 --> 04:34:21,869 ANY OTHER QUESTIONS? 7355 04:34:21,869 --> 04:34:23,270 THERE'S ONE. 7356 04:34:23,270 --> 04:34:23,938 KATIE? 7357 04:34:23,938 --> 04:34:24,905 >> YEAH, THANK YOU. 7358 04:34:24,905 --> 04:34:26,240 I REALLY APPRECIATED ALL THE 7359 04:34:26,240 --> 04:34:26,774 DISCUSSION OF SOCIAL 7360 04:34:26,774 --> 04:34:28,075 DETERMINANTS OF HEALTH TODAY. 7361 04:34:28,075 --> 04:34:32,246 I THINK THAT'S SO IMPORTANT. 7362 04:34:32,246 --> 04:34:35,416 TYING IT BACK, GEORGE, TO YOUR 7363 04:34:35,416 --> 04:34:38,052 CALL FOR TRANSLATIONAL, BACK 7364 04:34:38,052 --> 04:34:38,819 TRANSLATIONAL RESEARCH I 7365 04:34:38,819 --> 04:34:40,254 CHALLENGE COLLEAGUES DOING BASIC 7366 04:34:40,254 --> 04:34:43,190 SCIENCE WORK TO THINK ABOUT 7367 04:34:43,190 --> 04:34:46,394 ENVIRONMENT IN WAYS OF MODELING 7368 04:34:46,394 --> 04:34:47,128 ENVIRONMENTAL ENRICHMENT, 7369 04:34:47,128 --> 04:34:47,928 ENVIRONMENTAL ASPECTS, IN ANIMAL 7370 04:34:47,928 --> 04:34:49,764 MODELS BECAUSE I THINK IF WE'RE 7371 04:34:49,764 --> 04:34:52,299 NOT MODELING THAT AND INCLUDING 7372 04:34:52,299 --> 04:34:55,569 THAT, I KNOW IT GETS 7373 04:34:55,569 --> 04:34:56,370 COMPLICATED, I WOULD ADVOCATE 7374 04:34:56,370 --> 04:34:59,306 FOR A LOT OF THE RECENT WORK ON, 7375 04:34:59,306 --> 04:35:01,809 FOR EXAMPLE, SOCIAL CHOICE 7376 04:35:01,809 --> 04:35:03,978 HAVING THE CHOICE OF SOCIAL CUE 7377 04:35:03,978 --> 04:35:05,646 INSTEAD OF ALCOHOL CUE OR OTHER 7378 04:35:05,646 --> 04:35:08,048 WORK THAT HAS TRIED TO BRING IN 7379 04:35:08,048 --> 04:35:11,152 MORE OF SOCIAL ENVIRONMENTAL 7380 04:35:11,152 --> 04:35:12,420 FACTORS INTO ANIMAL MODELS AND 7381 04:35:12,420 --> 04:35:14,121 WE NEED MORE OF THAT. 7382 04:35:14,121 --> 04:35:17,658 AND SO I'M JUST GOING TO PUT OUT 7383 04:35:17,658 --> 04:35:18,659 THAT CHALLENGE. 7384 04:35:18,659 --> 04:35:21,195 >> I HAD THE SAME THOUGHT WHEN 7385 04:35:21,195 --> 04:35:22,062 NATHANIEL WAS TALKING, WHICH IS 7386 04:35:22,062 --> 04:35:24,565 THAT YOU MIGHT BE ABLE TO BREAK 7387 04:35:24,565 --> 04:35:28,936 DOWN SOME OF THE THREATS AT 7388 04:35:28,936 --> 04:35:32,873 LEAST, THREAT IN A BROAD SENSE 7389 04:35:32,873 --> 04:35:34,642 OF THE TERM, IN ANIMAL MODELS 7390 04:35:34,642 --> 04:35:34,975 DEVELOPMENT. 7391 04:35:34,975 --> 04:35:38,579 WE DO SOME OF THAT BUT, AGAIN, 7392 04:35:38,579 --> 04:35:39,914 IT'S NOT USUALLY SOME SPECIFIC 7393 04:35:39,914 --> 04:35:41,315 THREAT SO, YOU KNOW, IT WOULD BE 7394 04:35:41,315 --> 04:35:45,119 INTERESTING TO LOOK AT NEURAL 7395 04:35:45,119 --> 04:35:47,254 CIRCUITRY. 7396 04:35:47,254 --> 04:35:49,290 PARTICULARLY IF SOME OF THESE ON 7397 04:35:49,290 --> 04:35:51,158 MARMOSETS TAKE OFF BECAUSE THEY 7398 04:35:51,158 --> 04:35:53,027 HAVE A MUCH BETTER DEVELOPED 7399 04:35:53,027 --> 04:35:54,328 FRONTAL CORTEX THAN YOUR AVERAGE 7400 04:35:54,328 --> 04:35:56,831 MOUSE. 7401 04:35:56,831 --> 04:35:58,566 I MEAN, THERE MAY BE SOME VERY 7402 04:35:58,566 --> 04:36:00,134 SPECIAL MOUSE OUT THERE THAT I 7403 04:36:00,134 --> 04:36:02,970 DON'T KNOW ABOUT. 7404 04:36:02,970 --> 04:36:03,504 DAVID? 7405 04:36:03,504 --> 04:36:04,939 >> I ALSO RECALL SOME WORK DONE 7406 04:36:04,939 --> 04:36:08,242 A NUMBER OF YEARS AGO ON 7407 04:36:08,242 --> 04:36:09,877 PRIMATES, SOCIAL DOMINANCE. 7408 04:36:09,877 --> 04:36:12,146 SHOWING DIRECT EFFECTS ON -- 7409 04:36:12,146 --> 04:36:15,149 >> MICHAEL NADER, YES. 7410 04:36:15,149 --> 04:36:15,416 >> YEAH. 7411 04:36:15,416 --> 04:36:19,720 >> REALLY EXCELLENT WORK, 7412 04:36:19,720 --> 04:36:21,589 MICHAEL NADER, DOPAMINE SYSTEM, 7413 04:36:21,589 --> 04:36:23,757 FRONT CORTEX AS WELL. 7414 04:36:23,757 --> 04:36:26,827 >> THERE IS A LOT OF WORK IN 7415 04:36:26,827 --> 04:36:29,129 TERMS OF ISOLATION, STRESS, 7416 04:36:29,129 --> 04:36:30,898 TRYING TO UNDERSTAND HOW IT 7417 04:36:30,898 --> 04:36:33,300 AFFECTS VULNERABILITY TO TAKE 7418 04:36:33,300 --> 04:36:35,936 DRUGS BUT VULNERABILITY FOR 7419 04:36:35,936 --> 04:36:38,439 RELAPSING. 7420 04:36:38,439 --> 04:36:40,274 SO, EVEN THOUGH, YES, NON-HUMAN 7421 04:36:40,274 --> 04:36:40,875 PRIMATE APPROXIMATE US BETTER 7422 04:36:40,875 --> 04:36:44,778 THERE ARE MANY THINGS WE CAN DO 7423 04:36:44,778 --> 04:36:48,182 IN THE RODENT, IN WAYS THAT CAN 7424 04:36:48,182 --> 04:36:52,219 THEN INFORM. 7425 04:36:52,219 --> 04:36:54,188 I DO BELIEVE YOUR POINT IS WELL 7426 04:36:54,188 --> 04:36:57,358 TAKEN BECAUSE IN GENERAL WE TRY 7427 04:36:57,358 --> 04:36:58,259 TO ISOLATE THE PHARMACOLOGICAL 7428 04:36:58,259 --> 04:37:03,931 AGENT AS IF IT WAS BY ITSELF. 7429 04:37:03,931 --> 04:37:05,099 >> CHANGE OF TOPIC, IF ANYBODY 7430 04:37:05,099 --> 04:37:07,334 HAS ANYTHING ELSE ON THAT GO 7431 04:37:07,334 --> 04:37:09,169 AHEAD. 7432 04:37:09,169 --> 04:37:10,137 >> GO AHEAD, BILL. 7433 04:37:10,137 --> 04:37:11,472 WE CAN GO BACK AND FORTH. 7434 04:37:11,472 --> 04:37:14,108 >> I WANTED TO MAKE AN 7435 04:37:14,108 --> 04:37:14,475 OBSERVATION. 7436 04:37:14,475 --> 04:37:17,278 THAT IS COVID CAME UP A FEW 7437 04:37:17,278 --> 04:37:18,178 TIMES TODAY. 7438 04:37:18,178 --> 04:37:20,247 BUT IT GOT PUSHED TO THE 7439 04:37:20,247 --> 04:37:20,548 BACKGROUND. 7440 04:37:20,548 --> 04:37:21,982 WE'RE ALL CELEBRATING THAT 7441 04:37:21,982 --> 04:37:24,385 BECAUSE WE PROBABLY HAVE COVID 7442 04:37:24,385 --> 04:37:24,885 FATIGUE. 7443 04:37:24,885 --> 04:37:26,787 BUT I DO THINK IT'S WORTH JUST 7444 04:37:26,787 --> 04:37:28,889 HAVING ON THE RADAR SCREEN THAT 7445 04:37:28,889 --> 04:37:30,758 THE FURTHER AWAY IT GETS FROM 7446 04:37:30,758 --> 04:37:34,595 US, THE MORE WE'RE AT MEETINGS 7447 04:37:34,595 --> 04:37:37,531 LIKE THIS NOT WEARING MASKS AND 7448 04:37:37,531 --> 04:37:39,934 SO ON THE MORE WE NEED TO 7449 04:37:39,934 --> 04:37:41,802 REMEMBER LONG-TERM IMPACT ON 7450 04:37:41,802 --> 04:37:42,369 BEHAVIOR. 7451 04:37:42,369 --> 04:37:43,871 I TALKED TO COLLEAGUES AT NCI 7452 04:37:43,871 --> 04:37:45,306 VERY HAPPY ABOUT THE FACT THAT 7453 04:37:45,306 --> 04:37:46,740 CANCER SCREENING IS GOING BACK 7454 04:37:46,740 --> 04:37:48,075 UP AGAIN, HEALTH CARE DELIVERY 7455 04:37:48,075 --> 04:37:49,476 IS RETURNING TO WHERE IT SHOULD 7456 04:37:49,476 --> 04:37:53,614 BE, WHERE IT WAS PRE-PANDEMIC. 7457 04:37:53,614 --> 04:37:54,114 BUT BEHAVIORS, ADDICTIVE 7458 04:37:54,114 --> 04:37:54,848 BEHAVIORS IN PARTICULAR, DON'T 7459 04:37:54,848 --> 04:37:57,885 JUST SWITCH OFF AND ON, AS WE 7460 04:37:57,885 --> 04:37:58,652 ALL KNOW. 7461 04:37:58,652 --> 04:37:59,853 SO I'VE BEEN VOCAL ABOUT THE 7462 04:37:59,853 --> 04:38:01,622 FACT THAT I NEED -- WE NEED TO 7463 04:38:01,622 --> 04:38:05,125 BE TRACKING WHAT THE IMPACT OF 7464 04:38:05,125 --> 04:38:07,661 COVID IS ON ADDICTIVE BEHAVIORS 7465 04:38:07,661 --> 04:38:08,395 AND OTHER BEHAVIORS INDEPENDENT 7466 04:38:08,395 --> 04:38:10,164 OF TRENDS WE MIGHT HAVE BEEN 7467 04:38:10,164 --> 04:38:11,799 SEEING BEFORE THE PANDEMIC. 7468 04:38:11,799 --> 04:38:13,367 OBESITY, BY THE WAY, IS ON THAT 7469 04:38:13,367 --> 04:38:15,235 LIST, RATES HAVE GONE UP 7470 04:38:15,235 --> 04:38:16,303 DRAMATICALLY BUT DURING THE 7471 04:38:16,303 --> 04:38:19,073 PANDEMIC EVEN MORE SO, THAT 7472 04:38:19,073 --> 04:38:19,373 ACCELERATED. 7473 04:38:19,373 --> 04:38:23,110 SO IT'S MORE OF AN OBSERVATION, 7474 04:38:23,110 --> 04:38:24,078 SOMETHING WE'RE THINKING ABOUT 7475 04:38:24,078 --> 04:38:30,117 AND PERHAPS CAN MODEL OVER TIME 7476 04:38:30,117 --> 04:38:35,255 >> WE HAVE FOLLOWING AND SO IS 7477 04:38:35,255 --> 04:38:36,123 NIDA WITH OUR DIFFERENT 7478 04:38:36,123 --> 04:38:37,358 MONITORING IN THE FUTURE SOME OF 7479 04:38:37,358 --> 04:38:38,325 THESE THINGS BUT YOU'RE 7480 04:38:38,325 --> 04:38:39,293 ABSOLUTELY RIGHT. 7481 04:38:39,293 --> 04:38:40,828 I HAVEN'T FORGOTTEN ABOUT THE 7482 04:38:40,828 --> 04:38:46,867 PANDEMIC BY ANY MEANS. 7483 04:38:46,867 --> 04:38:48,969 >> AND ABCD, VERY THOROUGH 7484 04:38:48,969 --> 04:38:50,270 ANALYSIS WITH SUPPLEMENT TO HAVE 7485 04:38:50,270 --> 04:38:52,206 VARIABLES THAT RELATE TO COVID 7486 04:38:52,206 --> 04:38:54,308 PANDEMIC SO IT WILL ALLOW US TO 7487 04:38:54,308 --> 04:38:57,044 LOOK AT IT AS CHILDREN GROW, 7488 04:38:57,044 --> 04:38:57,678 UNDERSTANDING DOWNSTREAM 7489 04:38:57,678 --> 04:38:58,612 EFFECTS. 7490 04:38:58,612 --> 04:39:00,080 WE HAVE AN OPPORTUNITY BECAUSE 7491 04:39:00,080 --> 04:39:01,215 THIS WAS AN EXPERIMENT THAT 7492 04:39:01,215 --> 04:39:01,949 HAPPENED. 7493 04:39:01,949 --> 04:39:03,584 WE WERE LUCKY TO HAVE THE STUDY 7494 04:39:03,584 --> 04:39:09,723 IN THE MIDDLE SO IT ALLOWS US TO 7495 04:39:09,723 --> 04:39:11,058 UNDERSTAND LONG-TERM 7496 04:39:11,058 --> 04:39:12,693 CONSEQUENCES. 7497 04:39:12,693 --> 04:39:14,328 >> I FEEL LUCKY I SURVIVED THE 7498 04:39:14,328 --> 04:39:14,628 EXPERIMENT. 7499 04:39:14,628 --> 04:39:16,897 I'M IN THE AGE GROUP THAT MANY 7500 04:39:16,897 --> 04:39:21,935 DIDN'T, JUST FOR THE RECORD. 7501 04:39:21,935 --> 04:39:22,403 TINA? 7502 04:39:22,403 --> 04:39:24,304 >> QUESTION IS FOR NATE IF HE'S 7503 04:39:24,304 --> 04:39:25,105 STILL ON. 7504 04:39:25,105 --> 04:39:28,375 SO, I WAS REALLY INTRIGUED BY 7505 04:39:28,375 --> 04:39:30,110 YOUR PRESENTATION AND THOUGHT 7506 04:39:30,110 --> 04:39:32,312 THAT HPCD WOULD BE A GREAT PLACE 7507 04:39:32,312 --> 04:39:34,381 TO REPLICATE WHAT YOU'VE DONE IN 7508 04:39:34,381 --> 04:39:38,986 ABCD TO SEE IF THE ASSOCIATIONS 7509 04:39:38,986 --> 04:39:41,155 THAT YOU FIND IN BRAIN SHOULD BE 7510 04:39:41,155 --> 04:39:43,924 ATTRIBUTED TO RACE, DO YOU SEE 7511 04:39:43,924 --> 04:39:46,527 AT YOUNGER AGES, BUT CURIOUS IN 7512 04:39:46,527 --> 04:39:48,062 THE ABCD DATASET IF IT'S LARGE 7513 04:39:48,062 --> 04:39:51,265 ENOUGH TO BE ABLE TO LOOK AT 7514 04:39:51,265 --> 04:39:52,433 RELOCATION, SO DO YOU HAVE 7515 04:39:52,433 --> 04:39:54,935 INDIVIDUALS WHO MOVE FROM ONE 7516 04:39:54,935 --> 04:39:56,603 PLACE TO ANOTHER WHERE THEIR 7517 04:39:56,603 --> 04:39:57,571 CIRCUMSTANCES WERE DIFFERENT AND 7518 04:39:57,571 --> 04:39:59,339 WOULD YOU BE ABLE TO PERHAPS 7519 04:39:59,339 --> 04:40:04,445 LOOK AT THAT AS A COVARIATE IN 7520 04:40:04,445 --> 04:40:07,247 TERMS OF THE RELATIONSHIP 7521 04:40:07,247 --> 04:40:08,982 BETWEEN BRAIN AND RACE? 7522 04:40:08,982 --> 04:40:11,485 >> YEAH, BOTH ARE GREAT 7523 04:40:11,485 --> 04:40:11,885 QUESTIONS. 7524 04:40:11,885 --> 04:40:13,220 WORKING BACKWARDS, WE HAD A 7525 04:40:13,220 --> 04:40:14,455 SIMILAR THOUGHT THINKING ABOUT 7526 04:40:14,455 --> 04:40:17,591 AT LEAST LOOKING AT POTENTIAL 7527 04:40:17,591 --> 04:40:19,760 CHANGES IN, SAY, ADI BETWEEN 7528 04:40:19,760 --> 04:40:22,129 BASELINE YEAR 2 DATA SINCE WE 7529 04:40:22,129 --> 04:40:24,498 HAVEN'T LOOKED AT 5.0 AND 6.0 7530 04:40:24,498 --> 04:40:26,133 ISN'T OUT YET. 7531 04:40:26,133 --> 04:40:27,901 MY RECOLLECTION AND ACTUAL 7532 04:40:27,901 --> 04:40:32,039 PEOPLE CAN CORRECT ME, THERE 7533 04:40:32,039 --> 04:40:34,541 WASN'T CHANGE IN TERMS OF ADI, 7534 04:40:34,541 --> 04:40:37,611 WHEN WE LOOKED THERE WAS A VERY 7535 04:40:37,611 --> 04:40:37,945 SMALL NUMBER. 7536 04:40:37,945 --> 04:40:44,818 WE INITIALLY LOOKED AT 7537 04:40:44,818 --> 04:40:48,889 HIPPOCAMPAL VOLUME, CONTEXTUAL 7538 04:40:48,889 --> 04:40:50,124 MODULATION, STRESS SENSITIVE 7539 04:40:50,124 --> 04:40:50,724 NEUROBIOLOGY, I THINK THAT'S 7540 04:40:50,724 --> 04:40:52,392 REALLY MORE OF A POWER ISSUE AS 7541 04:40:52,392 --> 04:40:54,228 YOU WERE GETTING AT. 7542 04:40:54,228 --> 04:40:57,731 SO PERHAPS AS MORE YEARS GO ON, 7543 04:40:57,731 --> 04:40:59,733 MORE PEOPLE MIGHT MOVE AROUND, 7544 04:40:59,733 --> 04:41:01,268 MIGHT BE MORE OPPORTUNITY TO DO 7545 04:41:01,268 --> 04:41:04,104 FINE GRAIN ANALYSES. 7546 04:41:04,104 --> 04:41:06,940 THE OTHER QUESTION ABOUT HBCD, 7547 04:41:06,940 --> 04:41:07,708 SOUNDS GREAT. 7548 04:41:07,708 --> 04:41:08,709 THAT WOULD BE COOL TO DO. 7549 04:41:08,709 --> 04:41:11,645 HAPPY TO FIND AN R.A. TO WORK 7550 04:41:11,645 --> 04:41:13,180 THROUGH THE ABILITY TO GET 7551 04:41:13,180 --> 04:41:16,049 ACCESS TO DATA AND START THAT 7552 04:41:16,049 --> 04:41:18,018 PROCESS. 7553 04:41:18,018 --> 04:41:20,287 >> WE HAVE TIME FOR PROBABLY ONE 7554 04:41:20,287 --> 04:41:22,456 OR TWO MORE QUESTIONS IF ANYONE 7555 04:41:22,456 --> 04:41:24,258 HAS THEM. 7556 04:41:24,258 --> 04:41:27,227 OR WE CAN GIVE YOU BACK TWO 7557 04:41:27,227 --> 04:41:30,264 MINUTES OF YOUR LIVES. 7558 04:41:30,264 --> 04:41:32,466 ANYBODY OUT THERE? 7559 04:41:32,466 --> 04:41:33,333 GO AHEAD. 7560 04:41:33,333 --> 04:41:35,836 >> MORE OF A COMMENT. 7561 04:41:35,836 --> 04:41:38,338 I KEEP THINKING ABOUT -- I AGREE 7562 04:41:38,338 --> 04:41:39,673 COMPLETELY WITH BILL'S POINT 7563 04:41:39,673 --> 04:41:41,208 ABOUT THE PANDEMIC. 7564 04:41:41,208 --> 04:41:42,176 I THINK THERE'S A COLLECTIVE 7565 04:41:42,176 --> 04:41:45,078 TRAUMA ABOUT THE PANDEMIC AND 7566 04:41:45,078 --> 04:41:47,014 THERE'S A LOT OF SUPPRESSION OF 7567 04:41:47,014 --> 04:41:47,648 EVEN THINKING BIT. 7568 04:41:47,648 --> 04:41:49,716 I THINK YOUR POINT IS WELL TAKEN 7569 04:41:49,716 --> 04:41:50,751 BECAUSE I THINK WE'LL SEE 7570 04:41:50,751 --> 04:41:53,353 EFFECTS FOR A LONG TIME. 7571 04:41:53,353 --> 04:41:56,957 I WAS THINKING ABOUT WITH ALL 7572 04:41:56,957 --> 04:41:59,793 THE AMAZES PRESENTATIONS ABOUT 7573 04:41:59,793 --> 04:42:00,894 RESILIENCE FACTORS, TRYING -- WE 7574 04:42:00,894 --> 04:42:03,730 ALREADY KNOW WHAT SOME ARE BUT 7575 04:42:03,730 --> 04:42:04,698 TRYING TO ELUCIDATE RESILIENCE, 7576 04:42:04,698 --> 04:42:07,267 NOT ONLY THAT WE KNOW WHAT THOSE 7577 04:42:07,267 --> 04:42:10,003 ARE BUT THEN ARE THERE WAYS WE 7578 04:42:10,003 --> 04:42:10,771 TRANSLATE THAT INTO 7579 04:42:10,771 --> 04:42:12,639 IMPLEMENTATION LIKE WHAT DO WE 7580 04:42:12,639 --> 04:42:13,607 DO? 7581 04:42:13,607 --> 04:42:16,577 SO THERE ARE STUDIES ABOUT 7582 04:42:16,577 --> 04:42:17,444 NEIGHBORHOOD COHESION, BEING 7583 04:42:17,444 --> 04:42:20,848 RESILIENCE FACTOR FOR PEOPLE WHO 7584 04:42:20,848 --> 04:42:21,915 HAVE HAD OTHER ADVERSE 7585 04:42:21,915 --> 04:42:22,916 CIRCUMSTANCES, THERE ARE A WHOLE 7586 04:42:22,916 --> 04:42:25,552 RANGE OF THINGS THAT WE THINK 7587 04:42:25,552 --> 04:42:28,155 ABOUT IN TERMS OF FRIENDSHIPS, 7588 04:42:28,155 --> 04:42:28,822 MULTIPLE DIFFERENT INTERACTIONS, 7589 04:42:28,822 --> 04:42:30,123 WHAT DO WE DO WITH THAT 7590 04:42:30,123 --> 04:42:32,993 INFORMATION AND IS THERE A WAY 7591 04:42:32,993 --> 04:42:34,728 FOR US TO CONSIDER, YOU KNOW, 7592 04:42:34,728 --> 04:42:37,130 FROM A SCIENCE PERSPECTIVE WHAT 7593 04:42:37,130 --> 04:42:40,868 WE DO HOW DO WE PROVIDE 7594 04:42:40,868 --> 04:42:41,468 IMPLEMENTATION AND INCENTIVIZE 7595 04:42:41,468 --> 04:42:43,370 FOR SOME OF THOSE THINGS TO 7596 04:42:43,370 --> 04:42:46,073 PROTECT PEOPLE, YOU KNOW, AND 7597 04:42:46,073 --> 04:42:47,875 TRY TO, YOU KNOW, INCREASE 7598 04:42:47,875 --> 04:42:48,175 RESILIENCE. 7599 04:42:48,175 --> 04:42:50,510 WE KNOW WHAT SOME FACTORS ARE. 7600 04:42:50,510 --> 04:42:52,379 WE KNOW THAT INCOME, HOUSING 7601 04:42:52,379 --> 04:42:53,347 SECURITY, FOOD SECURITY, WE KNOW 7602 04:42:53,347 --> 04:42:55,883 WHAT A LOT OF THESE THINGS ARE. 7603 04:42:55,883 --> 04:42:58,919 SO WHAT DO WE DO FOR 7604 04:42:58,919 --> 04:42:59,720 IMPLEMENTATION SCIENCE TO 7605 04:42:59,720 --> 04:43:01,688 DEMONSTRATE THAT WE HAVE 7606 04:43:01,688 --> 04:43:03,190 ACTUALLY TAKEN CARE OF THOSE 7607 04:43:03,190 --> 04:43:05,626 THINGS, SO IT'S JUST A THOUGHT 7608 04:43:05,626 --> 04:43:09,329 BECAUSE WE'VE BEEN TALKING ABOUT 7609 04:43:09,329 --> 04:43:12,399 THE STRESSORS, AND SOME OF THE 7610 04:43:12,399 --> 04:43:13,500 FACTORS THAT PREDISPOSE PEOPLE 7611 04:43:13,500 --> 04:43:17,104 TO ADDICTION BUT WHAT CAN WE DO 7612 04:43:17,104 --> 04:43:18,605 IN ELUCIDATING AND IMPLEMENTING 7613 04:43:18,605 --> 04:43:20,908 THING WE KNOW HELP PEOPLE BUILD 7614 04:43:20,908 --> 04:43:21,208 RESILIENCE? 7615 04:43:21,208 --> 04:43:23,443 >> THERE ARE STUDIES AS YOU KNOW 7616 04:43:23,443 --> 04:43:25,512 PROBABLY THAT HAVE RANDOMIZED 7617 04:43:25,512 --> 04:43:26,113 INTERVENTIONS THAT IMPROVE THE 7618 04:43:26,113 --> 04:43:27,381 INCOME OF FAMILIES THAT ARE 7619 04:43:27,381 --> 04:43:29,683 VERY, VERY POOR. 7620 04:43:29,683 --> 04:43:31,218 ACTUALLY HAVE SHOWN SIGNIFICANT 7621 04:43:31,218 --> 04:43:32,419 IMPROVEMENTS IN BRAIN FUNCTION 7622 04:43:32,419 --> 04:43:35,923 OF THE NEONATES AND CHILDREN. 7623 04:43:35,923 --> 04:43:40,394 SO I GUESS PERHAPS YOUR QUESTION 7624 04:43:40,394 --> 04:43:43,697 GOES, YES, WE KNOW, BUT HOW DO 7625 04:43:43,697 --> 04:43:46,967 WE BUILD AT THE STRUCTURAL LEVEL 7626 04:43:46,967 --> 04:43:48,068 TO IMPACT THE POPULATION AT 7627 04:43:48,068 --> 04:43:48,368 LARGE. 7628 04:43:48,368 --> 04:43:50,170 THAT IS A QUESTION WE ALL NEED 7629 04:43:50,170 --> 04:43:51,672 TO THINK ABOUT. 7630 04:43:51,672 --> 04:43:55,409 >> OR CAN WE REVERSE SOME OF THE 7631 04:43:55,409 --> 04:43:56,043 CHANGES. 7632 04:43:56,043 --> 04:43:56,376 >> EXACTLY. 7633 04:43:56,376 --> 04:43:59,446 >> THAT'S A BIGGER CHALLENGE. 7634 04:43:59,446 --> 04:44:01,181 THAT'S A GOOD PLACE TO STOP AT 7635 04:44:01,181 --> 04:44:02,282 MAYBE CONSIDER AT NEXT CRAN. 7636 04:44:02,282 --> 04:44:03,717 I HAVE THE PRIVILEGE OF 7637 04:44:03,717 --> 04:44:06,787 ADJOURNING THE MEETING. 7638 04:44:06,787 --> 04:44:07,321 THE MEETING IS ADJOURNED. 7639 04:44:07,321 --> 04:44:09,957 [END OF PROGRAM] 7640 04:44:09,957 --> 04:44:15,963 7641 04:44:15,963 --> 04:44:26,006