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HELLO, I WOULD LIKE TO WELCOME

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EVERYONE TO ANOTHER INSTALLMENT

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OF THE NIH FDA COVID-19

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SCIENTIFIC INTEREST GROUP

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LECTURE SERIES.

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ON BEHALF OF THE STEERING

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COMMITTEE IT'S AN HONOR TO

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INTRODUCE TODAY'S SPEAKER.

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DR. DUNCAN MACCANNELL, IS THE

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DIRECTOR OF THE OFFICE OF

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ADVANCED MOLECULAR DETECTION,

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OAMD, HE HELPS STUDY PATHOGEN

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GENOMICS, SCIENTIFIC COMPUTING

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AND THE USE OF INNOVATE I REALLY

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LABORATORY TECHNOLOGIES ACROSS

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THE PUBLIC HEALTH SYSTEM.

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DR. MACCANNELL, HOLDS A

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BACHELOR'S OF SCIENCE FROM

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Mc GILL UNIVERSITY AND EARNED

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A MASTER OF BIOTECHNOLOGY AND

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Ph.D. IN INFECTIOUS DISEASE

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SAYS FROM THE UNIVERSITY OF

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CALGARY.

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IN 2006 DR. MACCANNELL, BEGAN A

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FELLOWSHIP AT CDC PULSE NET AND

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SERVED EVER SINCE AS A HEALTH

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MICROBIOLOGIST AND A MOLECULAR

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EPIDEMIOLOGIST.

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HE'S BEEN RECOGNIZED WITH A

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ARTHUR S. FLEMMING AWARD, HHS

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INNOVATES AWARDS ASSEMBLING'S

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PICK AND AN NCZED AWARD.

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HE IS A MUCH NEEDED ADVOCATE FOR

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THE RAPID, OPEN AND EQUITABLE

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CHANGE OF PATHOGEN SEQUENCE DATA

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AND HE BROADENS THE SCIENCE,

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TRAINING AND EXPERTISE TO HELP

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HEALTH PROFESSIONALS IMPROVE

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COVID OUTCOMES.

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WHEN THE PANDEMIC STRUCK, HIS

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ADVOCACY HELPED HIM ESTABLISH

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THE EMERGENCY RESPONSE,

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EPIDEMIOLOGY AND SURVEILLANCE OR

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SPHERES INITIATIVE WHICH SEEKS

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TO EXPAND THE USE OF PATHOGEN

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GENOMICS TO STRENGTHEN INFECT

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YOWZ DISEASE SURVEILLANCE AND

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OUTBREAK RESPONSE WHICH IS WHAT

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WE WILL BE SPEAKING ABOUT TODAY.

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SO WITH THAT WE ARE HONORED TO

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HAVE YOU HERE WITH US DUNCAN AND

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LEARNING ABOUT YOUR EXPERIENCES

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WITH SPHERES.

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>> THANK YOU SO MUCH.

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I'M GOING TO SHARE MY SCREEN AND

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THAT SHOULD WORK.

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LOOKS LIKE THAT'S GOOD.

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FIRST OF ALL, THANK YOU FOR THE

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OPPORTUNITY TO PRESENT TODAY.

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I KNOW IT TOOK A LITTLE WHILE TO

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GET THE SCHEDULE, IT HAS BEEN A

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LONG FEW YEARS, BUT I THINK THIS

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IS A REALLY INTERESTING AND

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ENLIGHTENING STORY.

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IN TALKING ABOUT IT THOUGH, I

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WANT TO TRY TO TIE IT INTO WHERE

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WE ARE IN THIS MOMENT WITH

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PATHOGEN GERONTOLOGYSTS GOMMICS

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SURVEILLANCE IN THE U.S. AS WE

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THINK ABOUT HOW THESE

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TECHNOLOGIES CAN BE APPLIED

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GLOBALLY AND HOW WE BUILD THE

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NECESSARY INFRASTRUCTURE AND

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WORKFORCE AND BROADER

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COLLABORATION ECOSYSTEM AROUND

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THESE TECHNOLOGIES AND THEIR

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APPLICATIONS TO PUBLIC HEALTH, I

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TOOK THE ORIGINAL TITLE THEY

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SUBMITTED OPTIMISTICALLY IT WAS

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A BIT OF A MOUTHFUL AND

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CHALLENGING TO PUT ON THE TITLE

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SLIDE.

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I TIGHTENED IT UP A BIT.

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BUT WE WILL TALK MOSTLY ABOUT

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NEW PARTNERSHIPS, WE WILL TALK

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ABOUT COLLABORATIONS AND HOW HOW

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THESE CAME INTO PLAY OVER THE

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PAST FEW YEARS.

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SO FIRST, I MUST INTRODUCE THE

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ADVANCED MOLECULAR DETECTION

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PROGRAM, THE COME FROM THE

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OFFICE THAT CHAIRS IT, IT WAS

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ESTABLISHED IN 2014 AS IN THE

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PRESIDENT'S BUDGET AS THE

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ADVANCE MOLECULAR DETECTION AND

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RESPONSE TO INFECT YOWZ DISEASES

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OR AMD BUDGET INITIATIVE.

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AT THE TIME IT WAS A

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30 MILLION-DOLLAR A YEAR PUBLIC

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HEALTH LABORATORY INNOVATION

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PROGRAM, IT'S NOW SITTING AT

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ABOUT $40 MILLION A YEAR WITH A

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FOCUS ON TRANSFORMATIONAL

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LABORATORY TECHNOLOGY COMPUTING.

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THIRTY, OR $40 MILLION SOUNDS

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LIKE A LOT FOR A FEDERAL PROGRAM

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BUT WHEN YOU REALIZE THE SCOPE

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OF THE MANDATE WHICH IS REALLY

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TRANSTHRAITING A LOT OF THESE

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EVENTS, TECHNOLOGIES AND

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PRACTICE ACROSS ALL THESE CDC

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INFECTIOUS DISEASE ACTIVITIES,

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ACROSS THE GLOBAL PARTNERS AND

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HEALTH SYSTEM, YOU START SLICING

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THE PIE RATHER FINELY.

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WE LAUNCHED WITH 5 INITIAL KEY

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OBJECTIVES, BUT REALLY IF YOU

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WANT TO THINK ABOUT AMD, IT'S

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EASIEST TO THINK ABOUT IT IN

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TERMS OF DOMAINS.

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A LOT OF WHAT WE FOCUSED ON IS

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ON LABORATORY SEQUENCING OR

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GENOMIC SEQUENCING BUT WE'RE NOT

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EXCLUSIVELY FOCUS ON THAT, I

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THINK A TRUE LINE FOR A LOT OF

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WHAT AMD DOES IS AROUND ADVANCED

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LABORATORY TECHNOLOGIES, HIGH

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COMPLEXITY, GENOMICS,

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PROTEOMICS, MULTIOMIC TYPE DATA

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SETS AS THEY BECOME PRACTICAL

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AND AS THEY BECOME INCORPORATED

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INTO PUBLIC HEALTH.

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ONE OF THE CONSISTENCIES IN THAT

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IS THAT IT OFTEN REQUIRES A LOT

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OF EMPHASIS ON CATAANALYSIS, ON

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INVESTMENT AND BIO-INFORMATICS,

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ON INSURING WE HAVE THE

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NECESSARY TECHNICAL

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INFRASTRUCTURE IN GOVERNANCE AND

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WORKFORCE, NECESSARY TO MAKE ALL

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THAT WORK TOGETHER EMPLOY WE

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ALSO NEED TO BE ABLE TO

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TRANSLATE WHAT THESE TYPES OF

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DATA INTO ACTION, WE NEED TO TIE

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THIS TO EPIDEMIOLOGY, TIE THIS

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TO FRONT LINE PUBLIC HEALTH.

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SO THESE REALLY FORM THE 3 MAIN

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PILLARS OF THE WORK THAT WE DO.

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WE HAVE MULTIPLE AREAS OF

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EMPHASIS, SO AS YOU MIGHT

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IMAGINE, A THE LO OF WHAT WE DO

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IS FOCUSED ON ADVANCED

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LABORATORY TECHNOLOGIES, LOOK AT

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THEM AS THEY EMERGE, FIGURE OUT

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HOW TO STANDARDIZE THEM AS MUCH

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AS WE CAN, IMPLEMENTING THEM IN

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WELL CENTRAL SOURCED

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LABORATORIES LIKE CDC BUT ALSO

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IN STATE AND LOCAL PUBLIC HEALTH

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DEPARTMENTS ACROSS THE COUNTRY

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IN GLOBAL PUBLIC HEALTH LABS

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ACROSS THE WORLD.

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WE WORK WITH A VARIETY OF

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DIFFERENT INSTRUMENT

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MANUFACTURES IN DOING SO, WE'RE

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ALSO LOOKING AT A LOT OF OTHER

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TECHNOLOGIES AS WELL AS THEY

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EMERGE, AS THEY BECOME A BIT

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MORE PRACTICAL, AS THEY FALL

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INTO THIS SORT OF REALM BUT

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AGAIN, SORT OF THE UNIFYING

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THEME THERE IS THAT MANY OF THEM

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ARE VERY DATA INTENSIVE AND MANY

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OF THEM REQUIRE SPECIALIZED

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SKILLS AND CAREFUL THOUGHT IN

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HOW THOSE DATA AND HOW THE

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INFORMATION FROM THOSE DATA CAN

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BE INCORPORATED INTO PUBLIC

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HEALTH.

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AND AGAIN, WE'RE NOT JUST

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FOCUSING ON WHAT CAN BE SOURCED

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IN A SINGLE LAB, WE ARE LOOKING

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AT WHAT CAN RUN IN A VARIETY OF

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DIFFERENT STATE AND LOCAL HEALTH

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DEPARTMENTS OR OUT IN THE FIELD

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IF WE HAVE TO ROLL SOMETHING OUT

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IN A MOBILE LAB.

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WE ALSO DO A FAIR BIT ON THE

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REALM OF PUBLIC INFORMATION

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TECHNOLOGY, HEALTH I.T. CAN BE

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CHALLENGING TO WORK IN, IT'S A

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COMPLEX ENVIRONMENT THAT

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INVOLVES MULTIPLE DIFFERENT

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PARTIES AND CHALLENGES AROUND

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THAT AND IT WASPT SET UP

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INITIALLY WHEN WE BEGAN THE

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PROGRAM TO SUPPORT THINGS LIKE

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BIO-INFORMATICS AND HIGH

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COMPLIANCE COMPUTING.

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WE'VE SINCE HAVE BEEN ABLE TO

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STAND UP CAPABILITIES AT CDC, WE

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CHAMPIONED A LOT OF EFFORTS AND

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PROBABLY TOWARDS THE END OF THE

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TALK TODAY I WILL TALK ABOUT THE

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UPCOMING CLOUD INITIATIVES THAT

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ARE MEANT TO PUSH SOME OF THESE

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OUT EENCH FURTHER INTO THE REALM

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OF PUBLIC HEALTH.

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WE ALSO DO A LOT ON LAB EPIDATA

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INTEGRATION, 1 OF THESE THINGS

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IS THAT THEY IMENERATE

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A--GENOMICS GENERATES A MASSIVE

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AMOUNT OF DATA BUT IT IS OFTEN

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MACHINE GRADABLE BY DEFAULT.

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A LOT OF THE DATA WE NEED TO

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INTEGRATE IT WITH THOUGH,

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CLINICAL METADATA, EPIDATA,

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CLINICIAN NOTES, FIELD NOTES,

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THEY'RE OFTEN POORLY STRUCTURED

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OR ASYNCHRONOUSLY DRIVED, SO

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FIGURING OUT NEW TECHNOLOGIES

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AND NEW WAYS TO BRING THESE DATA

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TOGETHER EFFECTIVELY AND

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EFFICIENTLY HAS BEEN AN ONGOING

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CHALLENGE FOR A LOT OF THE WORK

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THAT WE DO.

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THERE'S BEEN A LOT OF WORK IN

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THE PAST FEW YEARS IN DATA

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VISUALIZATION AND AND REPORTING,

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I WON'T TOUCH ON THOSE HERE BUT

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IF YOU THINK ABOUT TI NEVER

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WOULD HAVE PREDICTED THAT A FEW

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YEARS AGO THAT N TREES AND

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DASHBOARDS WOULD BE ON THE FRONT

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PAGES AS MAJOR RECORD BUT HERE

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WE ARE EMPLOY WE ALSO DO A LOT

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OF STRATEGIC COORDINATION AND

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PROGRAM SUPPORT.

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SO WE PROVIDE FUNDING

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ESSENTIALLY INNOVATION AND

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ADAPTATION FUNDING TO MANY

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DIFFERENT PROGRAMS WITHIN CDC,

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IT'S ABOUT 30 OR 40 DIFFERENT

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LABORATORY PROGRAMS AND THAT

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RANGES FROM LONG-TERM STRATEGIC

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TRANSITIONING EXISTING MOLECULAR

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SURVEILLANCE METHODS TO GENOMICS

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AND OTHER ADVANCED TECHNOLOGIES

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TO WHAT WE CALL INCUBATOR

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PROJECTS WHICH ARE HIGHER RISK,

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HIGH REWARD, R&D TYPE
ACTIVITIES

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THAT REALLY ENCOURAGE CDC

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PROGRAMS TO PUSH THE BOUNDS OF

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WHAT THEY'RE ALREADY DOING.

255
00:08:25,272 --> 00:08:27,608
WE DO A LOT OF COORDINATION WITH

256
00:08:27,608 --> 00:08:29,676
STATE BAKE BASED ACTIVITIES AND

257
00:08:29,676 --> 00:08:30,077
INITIATIVES.

258
00:08:30,077 --> 00:08:31,845
A LOT OF PARTNER WORK.

259
00:08:31,845 --> 00:08:33,580
WE WORK EXTENSIVELY ACROSS THE

260
00:08:33,580 --> 00:08:34,548
AGENCY WITH VARIOUS OTHER GROUPS

261
00:08:34,548 --> 00:08:36,750
THAT ARE ACTIVE IN THIS SPACE

262
00:08:36,750 --> 00:08:38,585
AND INCREASINGLY IN GLOBAL

263
00:08:38,585 --> 00:08:38,819
HEALTH.

264
00:08:38,819 --> 00:08:41,588
A LOT OF WHAT WE DO IS ALSO

265
00:08:41,588 --> 00:08:42,856
FOCUSED ON WORKFORCE DEVELOPMENT

266
00:08:42,856 --> 00:08:44,625
SO NOT ONLY MAINTAINING THE

267
00:08:44,625 --> 00:08:46,093
SKILL BASED OF CDC'S WORKFORCE

268
00:08:46,093 --> 00:08:48,729
BUT A LOT OF OUR STATE AND LOCAL

269
00:08:48,729 --> 00:08:50,264
PUBLIC HEALTH PARTNERS, WORKING

270
00:08:50,264 --> 00:08:51,331
ON RECRUITMENT STRATEGY FOR A

271
00:08:51,331 --> 00:08:54,768
LOT OF THESE TECHNICAL SKILLS ON

272
00:08:54,768 --> 00:08:56,170
THE NECESSARY ADMINISTRATIVE

273
00:08:56,170 --> 00:08:58,272
PROCESSES TO MAKE THAT HAPPEN,

274
00:08:58,272 --> 00:08:59,072
THINGS LIKE FELLOWSHIPS AND

275
00:08:59,072 --> 00:09:01,575
OTHER WAYS TO BRING IN THE

276
00:09:01,575 --> 00:09:03,443
TALENT AND NEW SKILLS THAT ARE

277
00:09:03,443 --> 00:09:04,945
DESPERATELY NEEDED TO MAKE THESE

278
00:09:04,945 --> 00:09:10,083
TECHNOLOGIES WORK CENTER FOR

279
00:09:10,083 --> 00:09:10,817
 EFFECTIVELY.

280
00:09:10,817 --> 00:09:11,818
LASTLY WE HAD SIGNIFICANT

281
00:09:11,818 --> 00:09:13,253
INNOVATION AND THAT CAN BE

282
00:09:13,253 --> 00:09:14,021
VETTING NEW TECHNOLOGIES WHEN

283
00:09:14,021 --> 00:09:15,656
THEY COME OR IT CAN BE FIGURING

284
00:09:15,656 --> 00:09:17,958
OUT WHERE THE GAPS ARE FOR

285
00:09:17,958 --> 00:09:19,593
IMPLEMENTATION IN THE LAST MILE

286
00:09:19,593 --> 00:09:20,794
FOR TAKING A TECHNOLOGY OUT OF

287
00:09:20,794 --> 00:09:23,096
THE LAB, OUT OF AN IERK DEALIZED

288
00:09:23,096 --> 00:09:24,298
SET OF CIRCUMSTANCES AND BEING

289
00:09:24,298 --> 00:09:26,667
ABLE TO ACTUALLY ARK PLIE IT FOR

290
00:09:26,667 --> 00:09:27,201
PUBLIC HEALTH.

291
00:09:27,201 --> 00:09:28,769
I'M NOT GOING TO TOUCH ON TOO

292
00:09:28,769 --> 00:09:30,571
MUCH OF THAT TODAY BUT IT'S A

293
00:09:30,571 --> 00:09:34,107
GREAT TOPIC THAT I WOULD LOVE TO

294
00:09:34,107 --> 00:09:35,475
TALK ABOUT LATER.

295
00:09:35,475 --> 00:09:37,411
SO LET'S TALK ABOUT WHERE WE

296
00:09:37,411 --> 00:09:39,913
STARTED AND WHERE WE ARE TODAY,

297
00:09:39,913 --> 00:09:43,417
AND THEN I'LL EASE US INTO THE

298
00:09:43,417 --> 00:09:43,984
COVID-19 RESPONSE.

299
00:09:43,984 --> 00:09:48,322
IF YOU LOOK BACK IN 2013, THERE

300
00:09:48,322 --> 00:09:50,057
REALLY WERE ONLY 6 OR 7 STATE OR

301
00:09:50,057 --> 00:09:51,225
LOCAL PUBLIC HEALTH DEPARTMENTS

302
00:09:51,225 --> 00:09:52,826
THAT HAD NEXT GENERATION

303
00:09:52,826 --> 00:09:54,127
SEQUENCING CAPABILITY AND IN

304
00:09:54,127 --> 00:09:56,797
MANY OF THOSE STATES, THE

305
00:09:56,797 --> 00:09:57,731
SEQUENCERS WEREN'T ACTUALLY

306
00:09:57,731 --> 00:09:59,466
LOCATED AT THE STATE PUBLIC

307
00:09:59,466 --> 00:10:00,734
HEALTH DEPARTMENT.

308
00:10:00,734 --> 00:10:03,570
AT THE TIME, MANY HEALTH STATE

309
00:10:03,570 --> 00:10:05,138
PUBLIC HEALTH DEPARTMENTS DIDN'T

310
00:10:05,138 --> 00:10:07,374
HAVE THE NECESSARY

311
00:10:07,374 --> 00:10:07,841
INFRASTRUCTURE WHETHER

312
00:10:07,841 --> 00:10:09,576
FACILITIES OR THE PERSONNEL THAT

313
00:10:09,576 --> 00:10:12,946
WERE TRAINED AND ABLE TO

314
00:10:12,946 --> 00:10:14,214
DEDICATE THE NECESSARY TIME

315
00:10:14,214 --> 00:10:16,450
RESOURCES TO THESE NEW

316
00:10:16,450 --> 00:10:16,750
INSTRUMENTS.

317
00:10:16,750 --> 00:10:19,519
A LOT OF THESE INITIAL

318
00:10:19,519 --> 00:10:21,154
PLACEMENTS WERE AROUND FOOD BORN

319
00:10:21,154 --> 00:10:23,657
DEC SURVEILLANCE SO THINGS LIKE

320
00:10:23,657 --> 00:10:29,663
PULSE NET AND FDA'S GENOME

321
00:10:29,663 --> 00:10:35,068
TRACKER, BUT YOU KNOW--TOOK OFF

322
00:10:35,068 --> 00:10:37,404
AND ENABLED BY SOME OF THESE

323
00:10:37,404 --> 00:10:40,073
PROGRAMS AND DEFINITELY DRIVEN

324
00:10:40,073 --> 00:10:41,408
BY AMD INVESTMENT.

325
00:10:41,408 --> 00:10:43,076
BY 2018, EVERY STATE AND PUBLIC

326
00:10:43,076 --> 00:10:47,114
HEALTH DEPARTMENT IN THE COUNTRY

327
00:10:47,114 --> 00:10:48,048
HAD SEQUENCING CAPABILITY, MANY

328
00:10:48,048 --> 00:10:50,150
COUNTY AND LOCAL PUBLIC HEALTH

329
00:10:50,150 --> 00:10:51,318
DEPARTMENTS ALSO HAD THAT KIND

330
00:10:51,318 --> 00:10:51,885
OF CAPABILITY.

331
00:10:51,885 --> 00:10:54,388
AND AGAIN, A LOT OF THE INITIAL

332
00:10:54,388 --> 00:10:57,758
INVESTMENT WAS FOCUSED ON FOOD

333
00:10:57,758 --> 00:10:58,925
BORNE DISEASE SURVEILLANCE BUT

334
00:10:58,925 --> 00:11:00,527
ONCE THERE, OTHER CDC PROGRAMS

335
00:11:00,527 --> 00:11:04,097
AND OTHER LOCAL AND STATE DRIVEN

336
00:11:04,097 --> 00:11:05,432
SURVEILLANCE AND ACTIVITY

337
00:11:05,432 --> 00:11:07,234
STARTED TO TAKE ADEVAPORATAGE OF

338
00:11:07,234 --> 00:11:07,868
THESE CAPABILITIES AND THE

339
00:11:07,868 --> 00:11:09,436
KNOWLEDGE THAT CAME WITH THEM

340
00:11:09,436 --> 00:11:11,638
EMPLOY MANY STATES FOCUSED ON

341
00:11:11,638 --> 00:11:12,939
INFLUENZA, HEALTHCARE ASSOCIATED

342
00:11:12,939 --> 00:11:16,276
INFECTIONS, THINGS LIKE VIRAL

343
00:11:16,276 --> 00:11:17,411
HEPATITIS, TUBERC CUEULOSEIS TO

344
00:11:17,411 --> 00:11:18,945
NAME A FEW BUT YOU STARTED TO

345
00:11:18,945 --> 00:11:20,514
SEE REALLY AN ADOPTION AND

346
00:11:20,514 --> 00:11:22,082
EXPLORATION OF THESE

347
00:11:22,082 --> 00:11:24,017
TECHNOLOGIES ALONG WITH EFFORTS

348
00:11:24,017 --> 00:11:28,789
TO TRY AND STANDARDIZE AND BUILD

349
00:11:28,789 --> 00:11:29,289
CONSISTENT SURVEILLANCE

350
00:11:29,289 --> 00:11:30,924
STRUCTURE ON TOP OF THEM.

351
00:11:30,924 --> 00:11:32,459
SO, YOU KNOW IF YOU ARE LOOKING

352
00:11:32,459 --> 00:11:34,194
AT THIS MAP, YOU MIGHT THINK

353
00:11:34,194 --> 00:11:36,496
THAT THE COUNTRY, OR THE U.S.

354
00:11:36,496 --> 00:11:40,233
PUBLIC HEALTH SYSTEM WAS WELL

355
00:11:40,233 --> 00:11:42,302
POSITIONED TO USE PATHOGEN

356
00:11:42,302 --> 00:11:45,472
GENOMICS AS AN APPROACH FOR AN

357
00:11:45,472 --> 00:11:46,740
ONCOMING PANDEMIC EVENT BUT YOU

358
00:11:46,740 --> 00:11:48,842
KNOW WHAT WE FOUND, BY THE END

359
00:11:48,842 --> 00:11:51,678
OF 2021, SO ESSENTIALLY OR I

360
00:11:51,678 --> 00:11:53,447
GUESS THAT'S 20--SORRY THAT

361
00:11:53,447 --> 00:11:56,683
WOULD BE TART OF 2024, A FULL

362
00:11:56,683 --> 00:11:58,418
YEAR INTO THE PANDEMIC, ONLY

363
00:11:58,418 --> 00:12:01,822
LESS THAN HALF OF THE STATE

364
00:12:01,822 --> 00:12:03,357
PUBLIC HEALTH DEPARTMENTS HAD

365
00:12:03,357 --> 00:12:04,424
SUBMITTED EVEN A SARS-COV-2

366
00:12:04,424 --> 00:12:06,960
SEQUENCE TO ANY OF THE PUB

367
00:12:06,960 --> 00:12:08,729
LIAISON REPOSITORIES OR TO CDC.

368
00:12:08,729 --> 00:12:10,230
THERE HAD BEEN FEDERAL

369
00:12:10,230 --> 00:12:11,698
SEQUENCING BUT YOU KNOW MANY OF

370
00:12:11,698 --> 00:12:12,666
THE STATE PUBLIC HEALTH

371
00:12:12,666 --> 00:12:14,201
DEPARTMENTS ISSUES EVEN THOUGH

372
00:12:14,201 --> 00:12:15,569
THE SEQUENCING CAPABILITY WAS IN

373
00:12:15,569 --> 00:12:17,671
PLACE, IT WAS OFTEN BUILT AROUND

374
00:12:17,671 --> 00:12:20,240
SPECIFIC PROGRAMS AND THE

375
00:12:20,240 --> 00:12:21,675
CAPACITY WAS DEEP BUT NARROW.

376
00:12:21,675 --> 00:12:26,012
AND SO WHEN FACED WITH A NEW AND

377
00:12:26,012 --> 00:12:28,048
EMERGING CHALLENGE AND A NEW

378
00:12:28,048 --> 00:12:29,015
PATHOGEN, IT WASN'T ALWAYS

379
00:12:29,015 --> 00:12:31,885
STRAIGHT FORWARD TO PIVOT THESE

380
00:12:31,885 --> 00:12:38,959
RESOURCES TO ADAPT TO ONCOMING

381
00:12:38,959 --> 00:12:39,192
THREAT.

382
00:12:39,192 --> 00:12:42,529
SO WHAT DID WE SEE, BY THE END

383
00:12:42,529 --> 00:12:44,498
OF 2020, THERE WERE JUST UNDER

384
00:12:44,498 --> 00:12:47,100
20 MILLION REPORTED U.S. CASES,

385
00:12:47,100 --> 00:12:49,136
THERE WERE ABOUT FEIVE THOUSAND,

386
00:12:49,136 --> 00:12:52,172
JUST OVER 57,000 SEQUENCES IN

387
00:12:52,172 --> 00:12:55,275
USAID AT THE TIME, A FEWER THAN

388
00:12:55,275 --> 00:12:57,010
THAT IN GENBANK AND THAT

389
00:12:57,010 --> 00:12:58,412
ENCLUEDED ABOUT 20 STATE AND

390
00:12:58,412 --> 00:13:00,147
PUBLIC HEALTH LABS SO DEFINITELY

391
00:13:00,147 --> 00:13:03,450
LESS THAN HALF.

392
00:13:03,450 --> 00:13:04,851
AND AN INTERESTING THING YOU'LL

393
00:13:04,851 --> 00:13:07,120
NOTE HERE IS THAT OVER HALF THE

394
00:13:07,120 --> 00:13:07,954
SEQUENCES GENERATED DURING THAT

395
00:13:07,954 --> 00:13:09,856
FIRST YEAR WERE NOT FROM STATE

396
00:13:09,856 --> 00:13:11,158
OR FEDERAL PUBLIC HEALTH

397
00:13:11,158 --> 00:13:12,426
ACTIVITIES, THEY WERE FROM

398
00:13:12,426 --> 00:13:15,562
EITHER PRIVATE SECTOR LABS OR

399
00:13:15,562 --> 00:13:16,797
ACADEMIC AND CLINICAL

400
00:13:16,797 --> 00:13:18,432
LABORATORIES THAT HAD ACCESS TO

401
00:13:18,432 --> 00:13:20,367
PATIENT SAMPLES THAT BEGAN

402
00:13:20,367 --> 00:13:22,002
SEQUENCING BUT THERE WEREN'T

403
00:13:22,002 --> 00:13:23,403
NECESSARILY CONNECTED TO THE

404
00:13:23,403 --> 00:13:28,575
PUBLIC HEALTH RESPONSE AT ANY

405
00:13:28,575 --> 00:13:29,376
LEVEL.

406
00:13:29,376 --> 00:13:34,648
AT THE CDC, WE STARTED WITH 2

407
00:13:34,648 --> 00:13:35,549
DIFFERENT APPROACHES, FIRST WAS

408
00:13:35,549 --> 00:13:39,586
TO REALLY  START PUTTING TOGETHR

409
00:13:39,586 --> 00:13:41,354
USEFUL INFORMATION FOR OUR STATE

410
00:13:41,354 --> 00:13:43,790
AND ACADEMIC PARTNERS THAT WERE

411
00:13:43,790 --> 00:13:46,159
BEGINNING TO SEQUENCE THE VIRUS.

412
00:13:46,159 --> 00:13:47,861
AT THE--ESPECIALLY IN THE EARLY

413
00:13:47,861 --> 00:13:50,497
DAYS OF THE RESPONSE, THERE WERE

414
00:13:50,497 --> 00:13:51,565
MANY DIFFERENT PROTOCOLS THAT

415
00:13:51,565 --> 00:13:53,934
WERE STARTING TO EMERGE, THERE

416
00:13:53,934 --> 00:13:54,868
WERE BIOINFORMATIC TOOLS THAT

417
00:13:54,868 --> 00:13:56,069
WERE STARTING TO BE DEVELOPED

418
00:13:56,069 --> 00:13:57,838
AND REFINED AND SO 1 THE INITIAL

419
00:13:57,838 --> 00:13:59,239
THINGS WE FELT WAS GOING TO BE

420
00:13:59,239 --> 00:14:02,209
USEFUL WAS TO SET UP AN

421
00:14:02,209 --> 00:14:02,809
INFORMATION CLEARINGHOUSE FOR

422
00:14:02,809 --> 00:14:07,347
SOME OF THESE PIECES OF DATA. 

423
00:14:07,347 --> 00:14:09,749
TO DO SO, GIVEN SOME OF THE

424
00:14:09,749 --> 00:14:10,984
CHALLENGES TIMES OF GOVERNMENT

425
00:14:10,984 --> 00:14:12,652
CLEARANCE PROCESSES AND THE FACT

426
00:14:12,652 --> 00:14:14,154
THAT THIS IS REALLY MEANT TO BE

427
00:14:14,154 --> 00:14:15,322
A CROWD SOURCED PIECE OF

428
00:14:15,322 --> 00:14:18,925
INFORMATION OR A SOURCE OF

429
00:14:18,925 --> 00:14:22,362
INFORMATION, WE WENT TO CDC'S

430
00:14:22,362 --> 00:14:24,464
GITHUB REPOSITORY AND SET UP A

431
00:14:24,464 --> 00:14:25,866
GITHUB PAGE THAT WAS WRITTEN AND

432
00:14:25,866 --> 00:14:27,434
MARKED DOWN.

433
00:14:27,434 --> 00:14:28,768
IT ALLOWED FOR ONGOING

434
00:14:28,768 --> 00:14:29,703
CONTRIBUTION, ONGOING EFCLIEWGZ

435
00:14:29,703 --> 00:14:32,672
OF THIS PAGE AS MORE AND MORE

436
00:14:32,672 --> 00:14:36,409
INFORMATION CAME ON. 

437
00:14:36,409 --> 00:14:37,043
ADDITIONAL CONTRIBUTORS COULD

438
00:14:37,043 --> 00:14:39,880
PROPOSE YOU KNOW ADDITIONAL

439
00:14:39,880 --> 00:14:41,248
CHANGES OR PUSH CHANGES TO THE

440
00:14:41,248 --> 00:14:42,449
PAGE OR SUBMIT THEM AND AT THE

441
00:14:42,449 --> 00:14:45,485
END OF THE DAY, WE ENDED UP

442
00:14:45,485 --> 00:14:46,686
MAKING ABOUT 330 COMMITS TO THIS

443
00:14:46,686 --> 00:14:50,457
IN THE FIRST YEAR OR SO OF THE

444
00:14:50,457 --> 00:14:52,859
PANDEMIC JUST OVER 20 DIFFERENT

445
00:14:52,859 --> 00:14:53,460
CONTRIBUTORS SUBMITTED CONTENT

446
00:14:53,460 --> 00:14:56,496
TO IT THAT WE REVIEWED AND

447
00:14:56,496 --> 00:14:57,397
INCLUDED.

448
00:14:57,397 --> 00:15:00,200
THIS INCLUDED UPDATES TO R-DEC

449
00:15:00,200 --> 00:15:02,969
PROTOCOLS, CHANGES IN NEW

450
00:15:02,969 --> 00:15:04,404
BIOINFORMATIC TOOLS, BOTH OPEN

451
00:15:04,404 --> 00:15:06,406
SOURCE AND PROPRIETARY THAT WERE

452
00:15:06,406 --> 00:15:07,574
AVAILABLE, INCLUDED IMPORTANT

453
00:15:07,574 --> 00:15:10,510
REFERENCES, IT ALSO INCLUDED

454
00:15:10,510 --> 00:15:11,444
SOME INITIAL RECOMMENDATIONS FOR

455
00:15:11,444 --> 00:15:15,148
HOW TO HANDLE SOME OF THE

456
00:15:15,148 --> 00:15:17,617
METADATA ISSUES AROUND SEQUENCE

457
00:15:17,617 --> 00:15:18,919
DATA SHARING BECAUSE 1 OF THE

458
00:15:18,919 --> 00:15:20,554
CHALLENGES THAT WE'VE SEEN, YOU

459
00:15:20,554 --> 00:15:23,490
KNOW ESPECIALLY WITH THE

460
00:15:23,490 --> 00:15:27,193
INCREASED OPENNESS OF SEQUENCE

461
00:15:27,193 --> 00:15:29,496
DATA SHARING, HAS BEEN VARIOUS

462
00:15:29,496 --> 00:15:32,265
LEVELS OF COMFORT AND VARIOUS

463
00:15:32,265 --> 00:15:34,134
LEVELS OF CHALLENGE AROUND

464
00:15:34,134 --> 00:15:34,801
SHARING PARTICULARLY THE

465
00:15:34,801 --> 00:15:36,436
METADATA ASSOCIATE WIDE THOSE

466
00:15:36,436 --> 00:15:36,903
SEQUENCES.

467
00:15:36,903 --> 00:15:38,004
THE MOST SALIENT EXAMPLE I

468
00:15:38,004 --> 00:15:41,875
USUALLY GO BACK TO IS BEFORE THE

469
00:15:41,875 --> 00:15:43,176
PANDEMIC, SALMONELLA WAS

470
00:15:43,176 --> 00:15:45,111
ROUTINELY SEQUENCED AS PART OF

471
00:15:45,111 --> 00:15:48,348
THE FOOD BORNE DISEASE

472
00:15:48,348 --> 00:15:52,552
SURVEILLANCE AS WELL AS LISTERIA

473
00:15:52,552 --> 00:15:54,321
AND SALMONELLA AND OTHER FOOD

474
00:15:54,321 --> 00:15:56,590
BORNE PATHOGENS BUT MANY OF

475
00:15:56,590 --> 00:15:58,091
THESE DIDN'T INCLUDEITATE LEVEL

476
00:15:58,091 --> 00:15:59,492
GEOLOCATION BECAUSE THERE WERE

477
00:15:59,492 --> 00:16:00,927
CONCERNS THAT YOU KNOW BY MANY

478
00:16:00,927 --> 00:16:02,429
OF THE SUBMITTERS THAT THERE WAS

479
00:16:02,429 --> 00:16:04,164
NOT NECESSARILY THE LEVEL OF

480
00:16:04,164 --> 00:16:06,933
COMFORT WITH SHARING THAT LEVEL

481
00:16:06,933 --> 00:16:07,300
OF METADATA.

482
00:16:07,300 --> 00:16:10,170
IN MANY CASES YOU WEREN'T

483
00:16:10,170 --> 00:16:13,273
LOOKING AT THINGS LIKE POTENTIAL

484
00:16:13,273 --> 00:16:16,343
REIDENTIFIABILITY OF INDIVIDUAL

485
00:16:16,343 --> 00:16:17,277
PATIENTS BUT CERTAINLY, HAVING

486
00:16:17,277 --> 00:16:18,378
STATE LEVEL DATA WAS SOMETHING

487
00:16:18,378 --> 00:16:20,013
THAT PEOPLE NEEDED TO ACTUALLY

488
00:16:20,013 --> 00:16:24,751
WRAP THEIR HEADS AROUND.

489
00:16:24,751 --> 00:16:25,952
THAT CHANGED DRAMATICALLY WITH

490
00:16:25,952 --> 00:16:27,120
THE PANDEMIC.

491
00:16:27,120 --> 00:16:29,155
WE SAW MANY JURISDICTIONS

492
00:16:29,155 --> 00:16:31,358
SHARINGITATE LEVEL, BUT TIMES

493
00:16:31,358 --> 00:16:34,828
COUNTY LEVEL INFORMATION. 

494
00:16:34,828 --> 00:16:39,165
IF THE DATA AND THEIR OVER SIGHT

495
00:16:39,165 --> 00:16:40,400
AND GORCHANCE PERMITTED THAT BUT

496
00:16:40,400 --> 00:16:43,837
1 THING WE DID DO IS STANDARDIZE

497
00:16:43,837 --> 00:16:46,239
HOW VIRUSES WERE NAMED THEY WERE

498
00:16:46,239 --> 00:16:50,143
SUBMITTED BASED ON SOME OF THE

499
00:16:50,143 --> 00:16:50,610
EARLY CDC'S MENTIONS.

500
00:16:50,610 --> 00:16:51,878
PART OF THE RATIONAL FOR DOING

501
00:16:51,878 --> 00:16:54,581
THIS WAS TO GET CONSISTENCY SO

502
00:16:54,581 --> 00:16:55,949
RECOMMENDATIONS FOR HOW SOME OF

503
00:16:55,949 --> 00:16:57,417
THE METADATA CAN BE COMPLETED

504
00:16:57,417 --> 00:16:59,252
BUT ALSO HOW WE CAN ACTUALLY

505
00:16:59,252 --> 00:17:09,763
MAKE SOME OF THE VIRAL DATA A

506
00:17:12,799 --> 00:17:14,901
BIT MORE USEFUL AND UNIQUE

507
00:17:14,901 --> 00:17:17,604
APPROACH FOR A CONSISTENT WAY

508
00:17:17,604 --> 00:17:20,740
FOR THESE NOMENCLATURES THAT WAS

509
00:17:20,740 --> 00:17:21,574
CONSISTENT WITH ICTV RECOMMEND

510
00:17:21,574 --> 00:17:22,642
ANTICIPATIONS AND OTHER CURRENT

511
00:17:22,642 --> 00:17:25,078
GUIDANCE BUT SAT THE SAME TIME

512
00:17:25,078 --> 00:17:27,080
GAVE ENOUGH INFORMATION THAT IF

513
00:17:27,080 --> 00:17:28,848
ALL OTHER METADATA FOR SEQUENCE

514
00:17:28,848 --> 00:17:31,151
WAS LOST, AN INDIVIDUAL COULD

515
00:17:31,151 --> 00:17:34,254
STILL TRACK DOWN WHICH STATE IT

516
00:17:34,254 --> 00:17:35,455
CAME FROM AND THE LAB THAT

517
00:17:35,455 --> 00:17:38,992
SUBMITTED IT AND A SAMPLE, A

518
00:17:38,992 --> 00:17:40,527
USEFUL SASMEM OF NUMBERS,

519
00:17:40,527 --> 00:17:41,961
EMBEDDING SOME OF THE MOST

520
00:17:41,961 --> 00:17:43,563
CRITICAL METADATA INTO THE NAME

521
00:17:43,563 --> 00:17:45,298
OF THE VIRUS ITSELF.

522
00:17:45,298 --> 00:17:48,134
THIS IS A CONVENTION THAT TOOK

523
00:17:48,134 --> 00:17:50,103
HOLD AND WAS ACTUALLY ENDED UP

524
00:17:50,103 --> 00:17:51,738
BEING PRETTY USEFUL BUT IT WAS

525
00:17:51,738 --> 00:17:54,641
AN EXAMPLE OF APPLYING SOME

526
00:17:54,641 --> 00:18:03,917
FAIRLY EARLY, FAIRLY GENTLE

527
00:18:03,917 --> 00:18:04,884
RECOMMENDATIONS AND AND SEEING

528
00:18:04,884 --> 00:18:06,753
WHERE THAT COULD POTENTIALLY GO.

529
00:18:06,753 --> 00:18:08,254
THE OTHER THING WE DID WAS TO

530
00:18:08,254 --> 00:18:10,023
START SEEING WHETHER WE COULD

531
00:18:10,023 --> 00:18:12,425
ACTUALLY ORGANIZE THE EFFORTS

532
00:18:12,425 --> 00:18:13,526
THAT WERE CURRENTLY ONGOING.

533
00:18:13,526 --> 00:18:15,095
THERE WERE PROBABLY ABOUT A

534
00:18:15,095 --> 00:18:16,930
DOZEN, MAYBE 2 DOZEN

535
00:18:16,930 --> 00:18:17,697
LABORATORIES ACROSS THE UNITED

536
00:18:17,697 --> 00:18:21,067
STATES THAT HAD BEEN SEQUENCING

537
00:18:21,067 --> 00:18:22,368
REGULARLY AND SO 1 OF THE FIRST

538
00:18:22,368 --> 00:18:24,070
EFFORTS WAS REALLY TO SEE

539
00:18:24,070 --> 00:18:25,238
WHETHER WE COULD ACTUALLY

540
00:18:25,238 --> 00:18:27,073
CONNECT ALL OF THESE DIFFERENT

541
00:18:27,073 --> 00:18:28,908
GROUPS INTO A COMMUNITY

542
00:18:28,908 --> 00:18:31,711
PRACTICE. 

543
00:18:31,711 --> 00:18:35,849
SO THIS INCLUDED A RANGE OF

544
00:18:35,849 --> 00:18:37,717
DIFFERENT FOLKS, IT'S FROM CDC

545
00:18:37,717 --> 00:18:41,154
LABS TO STATE AND LOCAL PUBLIC

546
00:18:41,154 --> 00:18:42,322
HEALTH, ACADEMIC AND CLINICAL

547
00:18:42,322 --> 00:18:44,190
NUMBER OF PRIVATE SECTOR

548
00:18:44,190 --> 00:18:47,460
ENTITIES WERE ON THIS AS WELL AS

549
00:18:47,460 --> 00:18:50,864
REPRESENTATIVES FROM MAJOR

550
00:18:50,864 --> 00:18:53,266
REPOSITORIES LIKE NCBI, AND

551
00:18:53,266 --> 00:18:53,633
[INDISCERNIBLE].

552
00:18:53,633 --> 00:18:54,934
THE INITIAL OUTREACH WAS REALLY

553
00:18:54,934 --> 00:18:57,403
MEANT TO SEE WHETHER WE BEING

554
00:18:57,403 --> 00:18:58,138
ACTUALLY NOT NECESSARILY CROWD

555
00:18:58,138 --> 00:19:00,807
SOURCE BUT HELP SHAPE A LOT OF

556
00:19:00,807 --> 00:19:01,608
THESTS THAT WERE CURRENTLY

557
00:19:01,608 --> 00:19:04,177
ONGOING TO TALK ABOUT DATA AND

558
00:19:04,177 --> 00:19:05,445
METADATA STANDARDS TO MAKE SURE

559
00:19:05,445 --> 00:19:09,048
WE WERE HAVING CONSISTENT

560
00:19:09,048 --> 00:19:09,816
CONVERSATIONS AROUND THAT WE

561
00:19:09,816 --> 00:19:11,351
COULD MAKE THE BEST USE OUT OF

562
00:19:11,351 --> 00:19:18,158
DATA THAT WAS BEING GENERATED

563
00:19:18,158 --> 00:19:20,126
THE OTHER PIECE IS THERE WERE

564
00:19:20,126 --> 00:19:21,895
JUST NOT ANY CONNECTED AT THE

565
00:19:21,895 --> 00:19:23,096
LOWER LEVEL AND SO THERE WAS A

566
00:19:23,096 --> 00:19:24,597
LOT OF DATA GENERATION GOING ON

567
00:19:24,597 --> 00:19:25,999
BUT WITHOUT THAT SORT OF

568
00:19:25,999 --> 00:19:27,634
CONNECTION OR FOLLOW THROUGH, IT

569
00:19:27,634 --> 00:19:30,170
WAS POSSIBLE THAT YOU KNOW THAT

570
00:19:30,170 --> 00:19:31,871
THESE SEQUENCING EFFORTS WOULD

571
00:19:31,871 --> 00:19:33,039
BECOME STAMP COLLECTING EFFORTS

572
00:19:33,039 --> 00:19:38,311
QUICKLY AND NOT NECESSARILY TIED

573
00:19:38,311 --> 00:19:40,647
TO ACTIONABLE PUBLIC HEALTH

574
00:19:40,647 --> 00:19:41,681
OUTCOMES.

575
00:19:41,681 --> 00:19:43,416
SO THIS INITIATIVE TOOK OFF, IT

576
00:19:43,416 --> 00:19:46,986
WAS ABOUT A DOZEN DIFFERENT

577
00:19:46,986 --> 00:19:49,722
GROUPS, AND IT TARTED REALLY TO

578
00:19:49,722 --> 00:19:52,325
SNOWBALL MORE QUICKLY THAN I

579
00:19:52,325 --> 00:19:53,593
THINK WE ANTICIPATED INITIALLY

580
00:19:53,593 --> 00:19:54,761
THE THOUGHT WAS TO BRING

581
00:19:54,761 --> 00:19:58,498
TOGETHER THIS GROUP TO START

582
00:19:58,498 --> 00:19:59,866
TALKING ABOUT AND APPROACHES TO

583
00:19:59,866 --> 00:20:02,302
REALLY CONNECT THESE MORE

584
00:20:02,302 --> 00:20:06,439
CONSISTENTLY TO PUBLIC HEALTH AS

585
00:20:06,439 --> 00:20:08,408
TIME WENT ON THOUGH THE

586
00:20:08,408 --> 00:20:12,812
CONTRIBUTING CONTINUED TO GROW.

587
00:20:12,812 --> 00:20:14,814
THE SPHERES ITSELF WAS AND IS A

588
00:20:14,814 --> 00:20:16,015
TECHNICAL COMMUNITY OF PRACTICE,

589
00:20:16,015 --> 00:20:17,650
IT'S MEANT TO PROVIDE A VENUE

590
00:20:17,650 --> 00:20:19,252
FOR NETWORKING AND COLLABORATION

591
00:20:19,252 --> 00:20:20,320
ISSUES IT'S MEANT TO TIE

592
00:20:20,320 --> 00:20:22,422
TOGETHER A LOT OF THESE

593
00:20:22,422 --> 00:20:23,356
DESPERATE SEQUENCING EFFORTS AND

594
00:20:23,356 --> 00:20:25,325
LABS THAT ARE INVOLVED IN THIS

595
00:20:25,325 --> 00:20:27,594
TO PROVIDE RAPID COMMUNICATION

596
00:20:27,594 --> 00:20:29,329
BETWEEN THESE DIFFERENT LABS AND

597
00:20:29,329 --> 00:20:31,764
TO ALLOW FOR MUCH MORE FLUID

598
00:20:31,764 --> 00:20:34,267
PUBLIC HEALTH ENGAGEMENT AND

599
00:20:34,267 --> 00:20:35,168
SHARING OF EXPERTISE.

600
00:20:35,168 --> 00:20:38,338
IT ALLOWED US TO BETTER ALIGN

601
00:20:38,338 --> 00:20:40,106
ACEM DICK AND PRIVATE SECTOR

602
00:20:40,106 --> 00:20:41,074
SEQUENCING EFFORTS WHICH WERE

603
00:20:41,074 --> 00:20:44,477
REALLY NEW TO THE PUBLIC HEALTH

604
00:20:44,477 --> 00:20:45,912
DOMAIN, OFTEN PUBLIC HEALTH

605
00:20:45,912 --> 00:20:46,846
LABORATORY TESTING HAPPENS IN A

606
00:20:46,846 --> 00:20:49,215
BIT OF A SILO, WE WORK WITH MANY

607
00:20:49,215 --> 00:20:51,251
CLINICAL LABS, MANY ACADEMIC

608
00:20:51,251 --> 00:20:53,653
PROVIDERS THAT'S USUALLY AROUND

609
00:20:53,653 --> 00:20:54,587
SPECIFIC PATHOGEN, SPECIFIC

610
00:20:54,587 --> 00:20:56,222
APPLICATIONS, THIS WAS A UNIQUE

611
00:20:56,222 --> 00:20:58,091
SET OF CIRCUMSTANCES WHERE, YOU

612
00:20:58,091 --> 00:20:59,726
KNOW ACADEMIC AND PRIVATE SECTOR

613
00:20:59,726 --> 00:21:02,262
LABS WERE STARTING TO ACTIVELY

614
00:21:02,262 --> 00:21:05,098
GENERATE FAIRLY LARGE AMOUNTS OF

615
00:21:05,098 --> 00:21:10,103
USEFUL DATA WITHOUT NECESSARILY

616
00:21:10,103 --> 00:21:11,104
HAVING THAT FACTOR.

617
00:21:11,104 --> 00:21:13,606
WE HAVE DIFFERENT PRACTICES BUT

618
00:21:13,606 --> 00:21:15,775
WE GAVE REGULAR VARIANT UPDATES

619
00:21:15,775 --> 00:21:17,210
OR WE GIVE REGULAR VARIANT

620
00:21:17,210 --> 00:21:19,979
UPDATES ON THE CURRENT STATE OF

621
00:21:19,979 --> 00:21:21,147
ESSENTIALLY THE OPEN DATA THAT'S

622
00:21:21,147 --> 00:21:22,715
OUT THERE.  SOME OF THE

623
00:21:22,715 --> 00:21:24,651
INTERPRETATIONS AND VIEWS OF CDC

624
00:21:24,651 --> 00:21:26,052
DASHBOARDS AND SOME OF THE OTHER

625
00:21:26,052 --> 00:21:30,323
PIECES OF INFORMATION THAT

626
00:21:30,323 --> 00:21:32,292
CAPTURE VARIANT DATA A LOT OF

627
00:21:32,292 --> 00:21:33,626
REPORTS ON CURRENT OUTBREAK

628
00:21:33,626 --> 00:21:40,533
INVESTIGATIONS AND SURVEILLANCE

629
00:21:40,533 --> 00:21:42,268
RESPONSE AND ONGOING TOPICAL

630
00:21:42,268 --> 00:21:43,670
EVENTS, WHETHER IT'S A NUMBER OF

631
00:21:43,670 --> 00:21:46,406
TALKS ON RETURN TO SCHOOL AND

632
00:21:46,406 --> 00:21:48,508
SOME OF THE VARIANT SURVEILLANCE

633
00:21:48,508 --> 00:21:52,278
ON COLLEGE CAMPUSES AND ACADEMIC

634
00:21:52,278 --> 00:21:54,547
INSTITUTIONS IN VARIOUS

635
00:21:54,547 --> 00:21:57,216
CONGREGATE SETTINGS, VARIOUS

636
00:21:57,216 --> 00:21:57,917
APPROACHES AND BIOINFORMATIC

637
00:21:57,917 --> 00:21:59,085
TOOLS THAT HAS BEEN DEVELOPED

638
00:21:59,085 --> 00:22:04,424
OVER THE YEARS AS WELL.

639
00:22:04,424 --> 00:22:05,858
AND VARIOUS DISCUSSIONS ON

640
00:22:05,858 --> 00:22:07,360
APPROACHES AND ANALYSIS AND DATA

641
00:22:07,360 --> 00:22:10,763
SHARING A LOT OF DISCUSSION ON

642
00:22:10,763 --> 00:22:11,331
LABORATORY AND BIOINFORMATIC

643
00:22:11,331 --> 00:22:14,000
METHODS AND WE TRY TO CREATE AN

644
00:22:14,000 --> 00:22:15,401
ENVIRONMENT THAT INCORPORATED

645
00:22:15,401 --> 00:22:17,036
NOT ONLY PUBLIC HEALTH AND

646
00:22:17,036 --> 00:22:20,473
ACADEMIC DEVELOP AMS AND R&D
BUT

647
00:22:20,473 --> 00:22:24,911
ALSO IN AN EQUITABLE MANNER,

648
00:22:24,911 --> 00:22:25,845
REPRESENTATIVES FROM THE PRIVATE

649
00:22:25,845 --> 00:22:28,047
SECTOR AS NEW KITS WERE

650
00:22:28,047 --> 00:22:29,349
DEVELOPED, AS NEW TOOLS WERE

651
00:22:29,349 --> 00:22:30,416
THERE, WE TRIED TO MAKE SURE

652
00:22:30,416 --> 00:22:32,719
THAT THINGS THAT WERE USEFUL HAD

653
00:22:32,719 --> 00:22:35,822
AN OPPORTUNITY TO BE SHOWCASED

654
00:22:35,822 --> 00:22:37,190
TO A TECHNICAL AUDIENCE.

655
00:22:37,190 --> 00:22:39,625
WE ALSO HAD THE OPPORTUNITY TO

656
00:22:39,625 --> 00:22:41,594
TALK PRETTY EXTENSIVELY ABOUT

657
00:22:41,594 --> 00:22:43,029
DATA AND METADATA STANDARDS SO

658
00:22:43,029 --> 00:22:46,866
WE WORKED WITH GROUPS LIKE SAGE

659
00:22:46,866 --> 00:22:50,303
AND THE PUBLIC HEALTH ALLIANCE

660
00:22:50,303 --> 00:22:52,171
FOR EPIDEMIOLOGY TO DEVELOP DATA

661
00:22:52,171 --> 00:22:53,139
STANDARDS.

662
00:22:53,139 --> 00:22:54,741
WORKED WITH DID NCBI TO ACTUALLY

663
00:22:54,741 --> 00:22:55,541
IMPLEMENT THEM AND THESE HAVE

664
00:22:55,541 --> 00:23:00,013
BEEN PUT ON THE BACK END FOR

665
00:23:00,013 --> 00:23:02,081
BOTH ISOLATES AND NCBI AS WELL

666
00:23:02,081 --> 00:23:03,383
AS WASTE WATER BASED

667
00:23:03,383 --> 00:23:05,385
EPIDEMIOLOGY WHICH I THINK IS AN

668
00:23:05,385 --> 00:23:07,253
IMPORTANT STEP FOR INSURING

669
00:23:07,253 --> 00:23:08,488
THERE'S THE NECESSARY STRUCTURE

670
00:23:08,488 --> 00:23:08,688
THERE.

671
00:23:08,688 --> 00:23:11,057
IT ALSO ALLOWED US TO TAYLOR A

672
00:23:11,057 --> 00:23:19,265
LOT OF CDC'S RESOURCES WE COULD

673
00:23:19,265 --> 00:23:21,367
REACH OUT TO OUR RESOURCES OVER

674
00:23:21,367 --> 00:23:22,502
THE PANDEMIC.

675
00:23:22,502 --> 00:23:25,004
IT ALLOWED US TO HAVE VERY

676
00:23:25,004 --> 00:23:26,639
DIRECT ENGAGEMENT WITH NOT ONLY

677
00:23:26,639 --> 00:23:27,473
THE SEQUENCERS THEMSELVES BUT A

678
00:23:27,473 --> 00:23:29,275
LOT OF THE TOOL DEVELOPERS, SO

679
00:23:29,275 --> 00:23:31,944
THE DEVELOPERS OF NEXT STRAIN

680
00:23:31,944 --> 00:23:34,380
AND MICROREACT AND OTHERS AND

681
00:23:34,380 --> 00:23:36,916
OUTBREAK.INFO AND MANY OTHER

682
00:23:36,916 --> 00:23:37,850
PLATFORMS WERE ACTIVELY INVOLVED

683
00:23:37,850 --> 00:23:39,819
IN THESE CONVERSATIONS AND

684
00:23:39,819 --> 00:23:42,789
ACCESSIBLE THROUGH THE SPHERES

685
00:23:42,789 --> 00:23:45,525
AND OTHER CHANNELS WHICH MEANT

686
00:23:45,525 --> 00:23:47,427
THAT OUR--AS THE COMMUNITY GREW,

687
00:23:47,427 --> 00:23:49,295
COMPLEXITY OF THESE TASKS

688
00:23:49,295 --> 00:23:49,862
CONTINUED TO MOVE.

689
00:23:49,862 --> 00:23:51,597
THERE WAS AN OPPORTUNITY FOR

690
00:23:51,597 --> 00:23:53,099
ONGOING DIALOGUE FOR FUTURE

691
00:23:53,099 --> 00:23:56,436
REQUESTS AND FOR ONGOING

692
00:23:56,436 --> 00:23:56,702
ANALYSIS.

693
00:23:56,702 --> 00:24:00,339
AS TIME WENT ON, I WILL TALK

694
00:24:00,339 --> 00:24:01,908
ABOUT RESOURCES IN A SECOND, BUT

695
00:24:01,908 --> 00:24:03,876
IT ALLOWED US TO HAVE A LITTLE

696
00:24:03,876 --> 00:24:06,412
BIT MORE TARGET WHEN WE'RE

697
00:24:06,412 --> 00:24:07,080
THINKING ABOUT SURVEILLANCE,

698
00:24:07,080 --> 00:24:09,482
RESEARCH FUNDING AND SUPPORT, SO

699
00:24:09,482 --> 00:24:10,683
WE STARTED USING BROAD AGENCY

700
00:24:10,683 --> 00:24:11,617
ANNOUNCEMENTS AND I WILL TALK

701
00:24:11,617 --> 00:24:14,387
ABOUT THAT IN A MOMENT, BUT IT

702
00:24:14,387 --> 00:24:16,222
ALLOWED US TO NOT ONLY ADVERTISE

703
00:24:16,222 --> 00:24:17,957
THOSE BUT TO CREATE THOSE SORTS

704
00:24:17,957 --> 00:24:20,793
OF OPPORTUNITIES THAT I THINK

705
00:24:20,793 --> 00:24:23,863
REALLY HELPED BUILD AND FOSTER

706
00:24:23,863 --> 00:24:27,967
THIS EARLY ACADEMIC PRIVATE

707
00:24:27,967 --> 00:24:29,068
SECTOR, PUBLIC SECTOR

708
00:24:29,068 --> 00:24:29,402
COLLABORATION.

709
00:24:29,402 --> 00:24:32,105
IT ALSO ALLOWED FOR US TO WORK

710
00:24:32,105 --> 00:24:33,072
ON IMPROVING INFRASTRUCTURE AND

711
00:24:33,072 --> 00:24:35,074
RESOURCES SO AS THE CDC

712
00:24:35,074 --> 00:24:38,511
DASHBOARD CAME OUT, IT GAVE

713
00:24:38,511 --> 00:24:41,314
OPPORTUNITIES FOR FEEDBACK AND

714
00:24:41,314 --> 00:24:41,747
PRIORITIZATION, USER

715
00:24:41,747 --> 00:24:42,748
ACCEPTABILITY TESTING ON SOME OF

716
00:24:42,748 --> 00:24:44,784
THE DATA RESOURCES WE WERE

717
00:24:44,784 --> 00:24:45,451
MAKING AVAILABLE.

718
00:24:45,451 --> 00:24:47,787
FEEDBACK ON SOME OF THE CONTEXT

719
00:24:47,787 --> 00:24:48,955
AND COMMUNICATIONS EFFORTS THAT

720
00:24:48,955 --> 00:24:51,691
WERE HAPPENING AROUND SOME OF

721
00:24:51,691 --> 00:24:52,391
THESE VARIANTS.

722
00:24:52,391 --> 00:24:54,827
AND MORE OVER PROVIDED A FORUM

723
00:24:54,827 --> 00:24:57,029
WHERE WE COULD TALK PRETTY

724
00:24:57,029 --> 00:25:02,001
CANDIDLY ABOUT WHEN THE GENOMIC

725
00:25:02,001 --> 00:25:06,405
EPI WAS SAYING, WHAT IT WASN'T

726
00:25:06,405 --> 00:25:07,874
SAYING, THE KNOWNS AND UNKNOWNS

727
00:25:07,874 --> 00:25:08,541
AT THE TIME.

728
00:25:08,541 --> 00:25:11,544
IT WAS HELPFUL TO HELP GUIDE THE

729
00:25:11,544 --> 00:25:13,279
ACADEMIC CONVERSATION AND

730
00:25:13,279 --> 00:25:13,980
BROADER PUBLIC CONVERSATION

731
00:25:13,980 --> 00:25:16,082
AROUND VARIANTS AS THEY EMERGED.

732
00:25:16,082 --> 00:25:17,550
THE FORMAT ITSELF WAS RELATIVELY

733
00:25:17,550 --> 00:25:19,218
STRAIGHT FORWARD, WE STARTED OFF

734
00:25:19,218 --> 00:25:25,458
WITH WEEKLY ZOOM CALLS, IT HAS

735
00:25:25,458 --> 00:25:26,959
GRADUALLY DWINDLED TO BI-WEEKLY

736
00:25:26,959 --> 00:25:27,827
AND MONTHLY CALLS ABOUT YOU

737
00:25:27,827 --> 00:25:29,929
THEY'RE STILL VERY ACTIVELY

738
00:25:29,929 --> 00:25:31,797
ATTENDED SO ABOUT 205 HELPED

739
00:25:31,797 --> 00:25:32,265
PARTICIPANTS USUALLY.

740
00:25:32,265 --> 00:25:34,800
WE HAVE VARIOUS TOPICS AND GUEST

741
00:25:34,800 --> 00:25:35,067
SPEAKERS.

742
00:25:35,067 --> 00:25:38,971
WE MAINTAIN AN ACTIVE GITHUB AND

743
00:25:38,971 --> 00:25:39,906
MULTIPLE DIFFERENT GITHUB

744
00:25:39,906 --> 00:25:44,143
PROJECTS WITHIN THAT AND AN

745
00:25:44,143 --> 00:25:45,578
ACTIVE WORK SPACE WHICH ACTS AS

746
00:25:45,578 --> 00:25:46,879
MISSION CONTROL FOR A LOT OF

747
00:25:46,879 --> 00:25:47,380
THESE DISCUSSIONS.

748
00:25:47,380 --> 00:25:51,184
SO WE STARTED OUT WITH A FEW

749
00:25:51,184 --> 00:25:53,252
DOZEN FOLKS HONESTLY, IF YOU

750
00:25:53,252 --> 00:25:55,054
WERE ASKING ME 4 YEARS AGO, HOW

751
00:25:55,054 --> 00:25:56,355
BIG THIS EFFORT WOULD GET, I

752
00:25:56,355 --> 00:25:58,591
WOULD HAVE TOLD YOU MAYBE A

753
00:25:58,591 --> 00:25:59,825
HUNDRED, MAYBE 200 PEOPLE WOULD

754
00:25:59,825 --> 00:26:01,160
BE INVOLVED AT THE END OF THE

755
00:26:01,160 --> 00:26:02,028
DAY.

756
00:26:02,028 --> 00:26:04,597
YOU KNOW AS THE PANDEMIC ROLLED

757
00:26:04,597 --> 00:26:05,765
ON.

758
00:26:05,765 --> 00:26:09,035
TODAY, IT'S OVER 1800 SCIENTISTS

759
00:26:09,035 --> 00:26:09,902
REPRESENTING MORE THAN 200

760
00:26:09,902 --> 00:26:10,870
ORGANIZATIONS, THIS IS AN OLDER

761
00:26:10,870 --> 00:26:12,271
SLIDE BUT IT DOES GIVE YOU A

762
00:26:12,271 --> 00:26:13,940
SENSE OF THE BREDTH OF

763
00:26:13,940 --> 00:26:15,541
PARTICIPATION, THE TYPES OF

764
00:26:15,541 --> 00:26:17,710
PARTICIPATION THAT ARE NOT ONLY

765
00:26:17,710 --> 00:26:19,779
ACROSS U.S. GOVERNMENT AND

766
00:26:19,779 --> 00:26:21,814
PUBLIC HEALTH, BUT ACROSS THE

767
00:26:21,814 --> 00:26:28,454
PRIVATE SECTOR IN ACADEMIA AS

768
00:26:28,454 --> 00:26:28,888
WELL.

769
00:26:28,888 --> 00:26:30,923
SO OUR FOCUS HAS STARTED TO

770
00:26:30,923 --> 00:26:31,490
EXPAND A LITTLE BIT.

771
00:26:31,490 --> 00:26:35,061
A LOT OF THIS WAS INITIALLY

772
00:26:35,061 --> 00:26:36,796
FOCUSED ON SARS-COV-2, SEQUENCE

773
00:26:36,796 --> 00:26:37,730
ANALYSIS AND SURVEILLANCE BUT WE

774
00:26:37,730 --> 00:26:40,066
HAVE STARTED TO BROADEN OUR

775
00:26:40,066 --> 00:26:41,767
FOCUS ON OTHER PATHOGENSAs

776
00:26:41,767 --> 00:26:42,168
WELL.

777
00:26:42,168 --> 00:26:47,073
WHEN THE INITIAL CASES OF THE

778
00:26:47,073 --> 00:26:48,608
MPOX WERE REPORTED THERE WAS A

779
00:26:48,608 --> 00:26:50,543
LOT OF ONGOING DISCUSSION AND

780
00:26:50,543 --> 00:26:53,312
UPDATES FROM NOT ONLY THE MPOX

781
00:26:53,312 --> 00:26:55,581
VIRUS GROUP AT CDC BUT ALSO FROM

782
00:26:55,581 --> 00:26:56,882
A NUMBER OF DIFFERENT GROUPS

783
00:26:56,882 --> 00:27:01,153
ACROSS THE U.S. THAT WERE EITHER

784
00:27:01,153 --> 00:27:02,788
CONDUCTING FRONT LINE PUBLIC

785
00:27:02,788 --> 00:27:04,757
HEALTH SURVEILLANCE AND GENOMIC

786
00:27:04,757 --> 00:27:05,591
SURVEILLANCE BUT ALSO RESPONSE

787
00:27:05,591 --> 00:27:05,791
WORK.

788
00:27:05,791 --> 00:27:07,360
I WILL IMAGINE THAT WE WILL

789
00:27:07,360 --> 00:27:08,427
CONTINUE TO EXPAND THIS SORT OF

790
00:27:08,427 --> 00:27:09,929
MISSION BECAUSE A LOT OF THE

791
00:27:09,929 --> 00:27:11,130
THEMES THAT WE COVER, A LOT OF

792
00:27:11,130 --> 00:27:12,665
THE EFFORTS THAT HAVE REALLY

793
00:27:12,665 --> 00:27:15,401
BEEN BUILT, A LOT OF THIS

794
00:27:15,401 --> 00:27:16,569
ECOSYSTEM AND COLLABORATION

795
00:27:16,569 --> 00:27:19,105
ENVIRONMENT IS REALLY FOCUSED ON

796
00:27:19,105 --> 00:27:20,106
GENOMIC EPIDEMIOLOGY AND

797
00:27:20,106 --> 00:27:30,650
BUILDING THIS KIND OF CAPABILITY

798
00:27:32,385 --> 00:27:35,588
ACROSS MULTIPLE SECTORS.

799
00:27:35,588 --> 00:27:36,856
SO THINGS CHANGED SOMEWHAT

800
00:27:36,856 --> 00:27:41,894
MARKETEDLY WHEN THE BIDEN

801
00:27:41,894 --> 00:27:42,828
ADMINISTRATION ANNOUNCED A

802
00:27:42,828 --> 00:27:44,864
$1.21 MILLION INVETMENT IN

803
00:27:44,864 --> 00:27:47,199
SURVEILLANCE AS PART OF THE

804
00:27:47,199 --> 00:27:47,767
AMERICAN RESCUE PLAN.

805
00:27:47,767 --> 00:27:50,903
BEFORE THAT WE HAD BEEN DOING

806
00:27:50,903 --> 00:27:52,438
WITH A LARGELY SHOE STRING

807
00:27:52,438 --> 00:27:54,006
BUDGET AND MOSTLY RELYING ON

808
00:27:54,006 --> 00:27:56,309
SEQUENCING THAT WAS HAPPENING AT

809
00:27:56,309 --> 00:27:57,843
CDC, A HANDFUL OFITATE AND LOCAL

810
00:27:57,843 --> 00:27:59,045
HEALTH DEPARTMENTS THAT WERE

811
00:27:59,045 --> 00:28:02,315
ABLE TO ALLOCATE THE RESOURCES

812
00:28:02,315 --> 00:28:03,949
AND THIS NETWORK OF ACADEMIC

813
00:28:03,949 --> 00:28:08,387
PARTNERS THAT WERE DOING AND

814
00:28:08,387 --> 00:28:09,288
ACTUALLY QUITE FORMIDABLE JOB.

815
00:28:09,288 --> 00:28:12,692
AS YOU CAN SEE, SEQUENCE OUTPUT

816
00:28:12,692 --> 00:28:13,726
ROSE DRAMATICALLY WITH THE

817
00:28:13,726 --> 00:28:15,494
INJECTION OF THESE ADDITIONAL

818
00:28:15,494 --> 00:28:15,761
RESOURCES.

819
00:28:15,761 --> 00:28:19,332
AS OF THIS WEEK, U.S. LABS HAVE

820
00:28:19,332 --> 00:28:26,839
SUBMITTED ABOUT 5.1 MILLION

821
00:28:26,839 --> 00:28:29,075
SEQUENCES TO GISAID, THEY

822
00:28:29,075 --> 00:28:30,376
SUBMITTED ABOUT 3.6 MILLION

823
00:28:30,376 --> 00:28:34,113
SEQUENCES TO GENBANK AND THAT IS

824
00:28:34,113 --> 00:28:35,481
IMPORTANT BECAUSE MANY OF THESE

825
00:28:35,481 --> 00:28:37,149
LABS, MANY U.S. LABS INCLUDING

826
00:28:37,149 --> 00:28:39,518
ALL THE FEDERAL EFFORTS ARE

827
00:28:39,518 --> 00:28:40,453
SUBMITTING TO MULTIPLE

828
00:28:40,453 --> 00:28:41,987
REPOSITORIES TO INSURE MAXIMUM

829
00:28:41,987 --> 00:28:44,090
OPENNESS AND AVAILABILITY OF THE

830
00:28:44,090 --> 00:28:44,390
DATA.

831
00:28:44,390 --> 00:28:46,292
AND THIS NUMBER'S A BIT OUT OF

832
00:28:46,292 --> 00:28:48,461
DATE, I APOLOGIZE, I GOT AN

833
00:28:48,461 --> 00:28:50,563
UPDATED NUMBER FROM THE NCBI

834
00:28:50,563 --> 00:28:51,897
JUST YESTERDAY, BUT I FAILED TO

835
00:28:51,897 --> 00:28:54,166
UPDATE IT HERE, I THINK WE'RE

836
00:28:54,166 --> 00:28:55,935
ALMOST AT 3 MILLION SEQUENCES IN

837
00:28:55,935 --> 00:28:58,604
SRA, WHICH IS FANTASTIC TO SEE.

838
00:28:58,604 --> 00:29:00,873
JUST TO GIVE YOU A SENSE OF

839
00:29:00,873 --> 00:29:02,675
OVERALL PROPORTIONS, ACTUALLY I

840
00:29:02,675 --> 00:29:05,411
DO THAT ON THE NEXT SLIDE, IT'S

841
00:29:05,411 --> 00:29:07,513
ABOUT 16 MILLION SEQUENCES RIGHT

842
00:29:07,513 --> 00:29:09,248
NOW IN GISAID, WHICH MAKES

843
00:29:09,248 --> 00:29:11,550
SARS-COV-2 1 OF THE MOST

844
00:29:11,550 --> 00:29:12,385
EXTENSIVELY SEQUENCED PATHOGENS

845
00:29:12,385 --> 00:29:16,822
IN HISTORY IF NOT THE MOST.

846
00:29:16,822 --> 00:29:18,557
ABOUT 16 MILLION SEQUENCES,

847
00:29:18,557 --> 00:29:20,893
ABOUT 31% OR JUST OVER 5 MILLION

848
00:29:20,893 --> 00:29:24,330
ARE FROM U.S. CASES, ABOUT 21%,

849
00:29:24,330 --> 00:29:27,633
ABOUT OVER A FIFTH OF ALL THE

850
00:29:27,633 --> 00:29:29,902
SEQUENCES THERE ARE FROM LOCAL

851
00:29:29,902 --> 00:29:31,537
STATE AND PUBLIC HEALTH

852
00:29:31,537 --> 00:29:33,105
SURVEILLANCE SO BEEN ABLE TO

853
00:29:33,105 --> 00:29:35,107
SUPER CHARGE THAT PRETTY

854
00:29:35,107 --> 00:29:37,309
EXTENSIVELY AND A FULL

855
00:29:37,309 --> 00:29:39,478
1.3 MILLION, A BIT MORE THAN

856
00:29:39,478 --> 00:29:42,848
THAT NOW, OR ABOUT 8%, 8-9% ARE

857
00:29:42,848 --> 00:29:44,550
FROM THE ACADEMIC AND CLINICAL

858
00:29:44,550 --> 00:29:48,621
LAB 

859
00:29:48,621 --> 00:29:51,490
LABORATORIES AND YOU CAN SEE THE

860
00:29:51,490 --> 00:29:53,559
BREAK DOWN IN DARK BLUE HERE,

861
00:29:53,559 --> 00:29:56,228
ORANGE AND FEDERAL SEQUENCING

862
00:29:56,228 --> 00:29:57,463
ACTIVITIES, LIGHT BLUE ARE

863
00:29:57,463 --> 00:29:58,497
ACADEMIC AND CLINICAL, AND YOU

864
00:29:58,497 --> 00:30:00,566
CAN SEE THAT ACADEMIC AND

865
00:30:00,566 --> 00:30:01,834
CLINICAL HAS PLAYED AN IMPORTANT

866
00:30:01,834 --> 00:30:02,201
ROLE.

867
00:30:02,201 --> 00:30:03,836
YOU ALSO SEE A SHOT OF PINK

868
00:30:03,836 --> 00:30:06,372
THROUGH A LOT OF THIS AND THAT

869
00:30:06,372 --> 00:30:07,740
IS PRIVATE SECTOR SEQUENCING

870
00:30:07,740 --> 00:30:09,608
THAT HAS OCCURRED VIRTUALLY

871
00:30:09,608 --> 00:30:10,776
THROUGHOUT THE PANDEMIC, AT

872
00:30:10,776 --> 00:30:12,978
VARIOUS LEVELS FOR VARIOUS

873
00:30:12,978 --> 00:30:13,245
PURPOSES.

874
00:30:13,245 --> 00:30:14,947
NOT ALL OF THESE DATA ARE

875
00:30:14,947 --> 00:30:17,883
NECESSARILY USEFUL FOR PUBLIC

876
00:30:17,883 --> 00:30:18,951
HEALTH SURVEILLANCE.

877
00:30:18,951 --> 00:30:21,187
WE DO HAVE STANDARDIZED METADATA

878
00:30:21,187 --> 00:30:22,488
TEXT IN THE DATA TO TRY AND

879
00:30:22,488 --> 00:30:27,426
CAPTURE SOME OF THE MORE

880
00:30:27,426 --> 00:30:27,960
REPRESENTATIVE POPULATION

881
00:30:27,960 --> 00:30:29,195
SEQUENCES IF WE CAN BECAUSE SOME

882
00:30:29,195 --> 00:30:33,299
MAY BE CAPTURED FOR A SPECIFIC

883
00:30:33,299 --> 00:30:35,334
STUDY OR FROM SPECIFIC COHORT OF

884
00:30:35,334 --> 00:30:37,203
PATIENTS OR FROM AN OUTBREAK

885
00:30:37,203 --> 00:30:38,037
INVESTIGATION WHICH MAKES THEM A

886
00:30:38,037 --> 00:30:40,105
LITTLE BIT LESS USEFUL, A LOT

887
00:30:40,105 --> 00:30:43,075
LESS USEFUL FOR NATIONAL

888
00:30:43,075 --> 00:30:45,377
SURVEILLANCE, BUT, YOU KNOW,

889
00:30:45,377 --> 00:30:48,013
THESE--THIS IS AN ENORMOUS BODY

890
00:30:48,013 --> 00:30:48,881
OF WORK AND CERTAINLY, YOU KNOW

891
00:30:48,881 --> 00:30:51,417
I WANT TO TALK IN A MOMENT ABOUT

892
00:30:51,417 --> 00:30:52,618
THE VALUE OF THIS RESEARCH

893
00:30:52,618 --> 00:30:55,120
ECOSYSTEM AND THE POTENTIAL OF

894
00:30:55,120 --> 00:30:57,623
BLENDING NOT ONLY PUBLIC HEALTH

895
00:30:57,623 --> 00:30:59,892
SURVEILLANCE BUT OPEN DATA

896
00:30:59,892 --> 00:31:00,326
COLLECTION.

897
00:31:00,326 --> 00:31:01,460
SO THE OTHER THING I WANT TO

898
00:31:01,460 --> 00:31:03,329
EMPHASIZE IS THAT THERE ARE

899
00:31:03,329 --> 00:31:05,064
DIFFERENT OBJECTIVES AND

900
00:31:05,064 --> 00:31:06,031
PRIORITIES FOR SEQUENCE DATA

901
00:31:06,031 --> 00:31:07,533
OPERATING IN DIFFERENT LEVELS.

902
00:31:07,533 --> 00:31:08,601
YOU KNOW SPHERES REALLY WAS

903
00:31:08,601 --> 00:31:10,102
MEANT TO TRY AND STITCH

904
00:31:10,102 --> 00:31:13,706
TOGETHER, DRAW TOGETHER, ALL OF

905
00:31:13,706 --> 00:31:16,008
THESE PUBLIC HEALTH AND

906
00:31:16,008 --> 00:31:18,177
NONCONVENTIONAL PUBLIC HEALTH

907
00:31:18,177 --> 00:31:21,146
PARTNERS THAT WE'RE SUDDENLY

908
00:31:21,146 --> 00:31:21,947
FOUND THEMSELVES SEQUENCING.

909
00:31:21,947 --> 00:31:23,916
IT ALLOWED FOR A FLUID PLATFORM

910
00:31:23,916 --> 00:31:24,750
WHERE WE COULD SHARE

911
00:31:24,750 --> 00:31:26,151
INFORMATION, WHERE WE COULD

912
00:31:26,151 --> 00:31:28,254
FACILITY WHERE NEEDED AND

913
00:31:28,254 --> 00:31:29,555
RAPIDLY REALLOCATE RESOURCES IF

914
00:31:29,555 --> 00:31:32,558
THAT MADE SENSE, IT ALLOWED US

915
00:31:32,558 --> 00:31:33,826
TO SHARE CAPACITY, PRIORITIZE

916
00:31:33,826 --> 00:31:36,729
SOME OF OUR OWN EFFORTS, AND

917
00:31:36,729 --> 00:31:39,231
IMPROVE THE UTILITY, QUALITY AND

918
00:31:39,231 --> 00:31:40,966
TIMELINESS OF THE QUALITY

919
00:31:40,966 --> 00:31:41,667
INFORMATION BEING GENERATED

920
00:31:41,667 --> 00:31:43,869
EMPLOY WE PUT IN PLACE A NUMBER

921
00:31:43,869 --> 00:31:46,405
OF DIFFERENT FEDERAL ACTIVITIES

922
00:31:46,405 --> 00:31:49,008
SO CDC'S NSTHEIR, OR SARS-COV-2

923
00:31:49,008 --> 00:31:50,576
SURVEILLANCE PROGRAM IS KEENED

924
00:31:50,576 --> 00:31:53,612
OF A CONVENTIONAL NATIONAL

925
00:31:53,612 --> 00:31:55,814
SURVEILLANCE EFFORT,ITATE PUBLIC

926
00:31:55,814 --> 00:31:57,349
HEALTH DEPARTMENTS SEND IN A

927
00:31:57,349 --> 00:31:59,084
REGULAR REPRESENTATIVE SET OF

928
00:31:59,084 --> 00:32:00,419
POSITIVE SPECIMENS THEY RECEIVE

929
00:32:00,419 --> 00:32:01,487
ETCH MONTH.

930
00:32:01,487 --> 00:32:04,223
THEY COME IN TO CDC AND RUN

931
00:32:04,223 --> 00:32:06,992
THROUGH A STAN ARDIZEED SET OF

932
00:32:06,992 --> 00:32:08,427
PIPELINES AND ARE SEEN IN A

933
00:32:08,427 --> 00:32:09,395
FAIRLY CONSIST EPT WAY.

934
00:32:09,395 --> 00:32:11,697
IT BIFFS US A FAIRLY BASE LINE

935
00:32:11,697 --> 00:32:15,367
HEART BEAT OF CIRCULATING

936
00:32:15,367 --> 00:32:16,769
BIODIVERSITY IN THE COUNTRY AND

937
00:32:16,769 --> 00:32:17,836
REALLY NOT THAT DIFFERENT FOR

938
00:32:17,836 --> 00:32:19,238
WHAT HAPPENS FOR FLU

939
00:32:19,238 --> 00:32:23,075
SURVEILLANCE AND OTHER VIRAL

940
00:32:23,075 --> 00:32:23,342
PATHOGENS.

941
00:32:23,342 --> 00:32:25,311
ONE ADDITION THAT REALLY ALLOWED

942
00:32:25,311 --> 00:32:26,946
US TO ACCELERATE THING SYSTEM

943
00:32:26,946 --> 00:32:29,014
THE INCLUSION OF THE COMMERCIAL

944
00:32:29,014 --> 00:32:31,650
LABS, REALIZING THAT IN MANY

945
00:32:31,650 --> 00:32:34,687
WAYS, SEQUENCING VIRUSES IS

946
00:32:34,687 --> 00:32:37,122
SOMETHING THAT IS SOMETHING THAT

947
00:32:37,122 --> 00:32:40,559
CAN BE COMODITIZED, IT'S NOT A

948
00:32:40,559 --> 00:32:41,460
HIGHLY SPECIALIZED FUNCTION.

949
00:32:41,460 --> 00:32:44,229
IN MANY CASES IT'S ACCESS TO

950
00:32:44,229 --> 00:32:45,097
APPROPRIATE AND REPRESENT NEW

951
00:32:45,097 --> 00:32:47,399
SPECIMENS THAT IS THE BIGGEST

952
00:32:47,399 --> 00:32:48,701
CHALLENGE FOR EFFECTIVE

953
00:32:48,701 --> 00:32:49,034
SURVEILLANCE.

954
00:32:49,034 --> 00:32:50,769
BY WORKING WITH SOME OF THE

955
00:32:50,769 --> 00:32:52,104
NATIONAL LABS, SOME OF THE

956
00:32:52,104 --> 00:32:53,739
BIGGER NATIONAL LABS, AT 1 POINT

957
00:32:53,739 --> 00:32:56,909
WE WERE WORKING WITH 9 DIFFERENT

958
00:32:56,909 --> 00:32:59,011
LARGE SCALE REGIONAL OR NATIONAL

959
00:32:59,011 --> 00:33:03,182
LABORATORIES, NOW WE'RE DOWN TO

960
00:33:03,182 --> 00:33:03,549
3.

961
00:33:03,549 --> 00:33:05,918
IT ALLOWED FOR CAPTURE OF

962
00:33:05,918 --> 00:33:09,488
POSITIVE SPECIMENS FROM A VERY

963
00:33:09,488 --> 00:33:10,489
WIDE FOOTPRINT CROSS THE

964
00:33:10,489 --> 00:33:11,323
GEOGRAPHY FROM THE UNITED STATES

965
00:33:11,323 --> 00:33:13,292
FROM A VARIETY OF DIFFERENT

966
00:33:13,292 --> 00:33:14,827
CONTEXT, FROM PHARMACIES TO

967
00:33:14,827 --> 00:33:16,762
PHYSICIAN'S OFFICES TO TERTIARY

968
00:33:16,762 --> 00:33:19,932
CARE, AND ALLOWED US TO GET A

969
00:33:19,932 --> 00:33:20,633
REALLY MORE COMPREHENSIVE

970
00:33:20,633 --> 00:33:22,668
COMPLETE VIEW OF WHAT WAS GOING

971
00:33:22,668 --> 00:33:26,438
ON AND WHAT WAS CIRCULATING.

972
00:33:26,438 --> 00:33:28,674
AT A NATIONAL LEVEL, THE GOAL IS

973
00:33:28,674 --> 00:33:30,743
REALLY TO PROVIDE NATIONAL BASE

974
00:33:30,743 --> 00:33:32,745
LINE MONITORING AND VARIANCE

975
00:33:32,745 --> 00:33:35,047
SURVEILLANCE TO HELP WITH RISK

976
00:33:35,047 --> 00:33:36,215
ASSESSMENT, ALLOCATE RESOURCES

977
00:33:36,215 --> 00:33:38,083
TO ASSESS THE EFFICACY OF

978
00:33:38,083 --> 00:33:39,251
VACCINES AND THERAPEUTIC ANDS

979
00:33:39,251 --> 00:33:40,853
HELP MAKE THOSE LARGER

980
00:33:40,853 --> 00:33:41,153
DECISIONS.

981
00:33:41,153 --> 00:33:42,988
BUT WE ALSO REALIZED THAT IN

982
00:33:42,988 --> 00:33:44,123
THINKING ABOUT SPHERES AND

983
00:33:44,123 --> 00:33:48,060
THINKING ABOUT ALL THE DIFFERENT

984
00:33:48,060 --> 00:33:48,794
DATA,--DATA CAPTURE SEQUENCING

985
00:33:48,794 --> 00:33:49,995
EFFORTS THAT WERE HAPPENING

986
00:33:49,995 --> 00:33:51,730
AROUND THE COUNTRY, WE ALSO

987
00:33:51,730 --> 00:33:53,999
NEEDED TO ACCOMMODATE THE USES

988
00:33:53,999 --> 00:33:56,201
AT STATE AND LOCAL PUBLIC HEALTH

989
00:33:56,201 --> 00:33:59,605
LEVEL, SO MAKING SURE THAT LOCAL

990
00:33:59,605 --> 00:34:01,507
SURVEILLANCE MONITORING FOR

991
00:34:01,507 --> 00:34:03,008
OUTBREAK INVESTIGATIONS, CONTACT

992
00:34:03,008 --> 00:34:04,743
TRACING WHERE APPROPRIATE,

993
00:34:04,743 --> 00:34:05,644
INFECTION CONTROL PRACTICES

994
00:34:05,644 --> 00:34:07,279
COULD ALSO MAKE USE OF THESE

995
00:34:07,279 --> 00:34:07,713
DATA.

996
00:34:07,713 --> 00:34:09,581
ONE OF THE CHALLENGES THAT THIS

997
00:34:09,581 --> 00:34:12,051
HAD WAS, YOU KNOW A LOT OF THE

998
00:34:12,051 --> 00:34:13,018
NATIONAL DATA IS DEIESH

999
00:34:13,018 --> 00:34:14,319
DENTIFIED AT THAT LEVEL, WE HAD

1000
00:34:14,319 --> 00:34:16,221
TO BUILD IN MECHANISMS TO,A LOW

1001
00:34:16,221 --> 00:34:19,191
FORITATE AND LOCAL PUBLIC HEALTH

1002
00:34:19,191 --> 00:34:21,026
DEPARTMENTS TO   PERFORM

1003
00:34:21,026 --> 00:34:22,061
REIDENTIFICATION OF CASES OR BE

1004
00:34:22,061 --> 00:34:24,863
ABLE TO LINK THEM WITH MORE

1005
00:34:24,863 --> 00:34:25,798
DETAILED METADATA SO THEY COULD

1006
00:34:25,798 --> 00:34:28,067
USE SOME OF THESE FEDERALLY

1007
00:34:28,067 --> 00:34:29,868
GATHERED SEQUENCES IN PART OF

1008
00:34:29,868 --> 00:34:33,138
THEIRITATE AND LOCAL RESPONSE

1009
00:34:33,138 --> 00:34:33,439
ACTIVITY.

1010
00:34:33,439 --> 00:34:34,506
I TALKED ABOUT MULTIPLE

1011
00:34:34,506 --> 00:34:35,607
SUBMISSIONS AND THE IMPORTANCE

1012
00:34:35,607 --> 00:34:37,142
OF THAT, YOU KNOW 1 THING THAT I

1013
00:34:37,142 --> 00:34:38,677
THINK I WOULD LIKE TO UNDERSCORE

1014
00:34:38,677 --> 00:34:40,312
IS WE'VE BEEN WORKING ON A LOT

1015
00:34:40,312 --> 00:34:41,847
OF THE TOOLING TO TRY TO MAKE

1016
00:34:41,847 --> 00:34:45,384
THIS EASIER TO TRY AND MAKE

1017
00:34:45,384 --> 00:34:47,453
CONSISTENT METADATA A MUCH MORE

1018
00:34:47,453 --> 00:34:50,689
ACTIVE REALITY AND TO  INSURE

1019
00:34:50,689 --> 00:34:52,524
THAT THE DATA WE'RE GENERATING,

1020
00:34:52,524 --> 00:34:55,327
YOU KNOW IN SUPPORT OF NOT ONLY

1021
00:34:55,327 --> 00:34:57,429
PANDEMIC RESPONSE BUT IN

1022
00:34:57,429 --> 00:34:59,131
TAXPAYER FUBDED EFFORTS, SHOULD

1023
00:34:59,131 --> 00:35:01,133
BE MAXIMALLY USEFUL AND NOT ONLY

1024
00:35:01,133 --> 00:35:04,036
FOR PUBLIC HEALTH, BUT IDEALLY

1025
00:35:04,036 --> 00:35:13,545
RESEARCH AND R&D.

1026
00:35:13,545 --> 00:35:14,713
LET'S LOOK AT THE DIRECTION

1027
00:35:14,713 --> 00:35:17,015
THINGS ARE GOING AND TO DO SO, I

1028
00:35:17,015 --> 00:35:19,017
WANT TO SHOW THIS RELATIVELY

1029
00:35:19,017 --> 00:35:22,154
SIMPLE CARTOON OF HOW PATHOGEN

1030
00:35:22,154 --> 00:35:23,055
GENOMICS AND GENOMICS

1031
00:35:23,055 --> 00:35:24,923
SURVEILLANCE WORK IN A LOT OF

1032
00:35:24,923 --> 00:35:26,125
DIFFERENT CONTEXT, SO FROM

1033
00:35:26,125 --> 00:35:27,526
PATIENTS YOU HAVE PRIMARY

1034
00:35:27,526 --> 00:35:28,093
DIAGNOSTIC TESTING THAT CAN

1035
00:35:28,093 --> 00:35:30,162
HAPPEN IN A VARIETY OF DIFFERENT

1036
00:35:30,162 --> 00:35:33,298
SETTINGS, SOME OF THOSE SAMPLES

1037
00:35:33,298 --> 00:35:35,734
ARE MOVING FORWARD TO MORE

1038
00:35:35,734 --> 00:35:37,536
ADVANCED OR ESOTERIC TESTING

1039
00:35:37,536 --> 00:35:38,370
WHICH INCLUDES SEQUENCING.

1040
00:35:38,370 --> 00:35:41,206
IDEALLY YOU HAVE A GOOD

1041
00:35:41,206 --> 00:35:43,976
INTEGRATION WITH SEQUENCING, THE

1042
00:35:43,976 --> 00:35:45,277
BIO-INFORMATICS CORE TO ACTUALLY

1043
00:35:45,277 --> 00:35:47,112
MAKE AND EXPERTISE NEEDED TO

1044
00:35:47,112 --> 00:35:49,448
TURN THOSE DATA INTO MEANINGFUL

1045
00:35:49,448 --> 00:35:49,915
INFORMATION.

1046
00:35:49,915 --> 00:35:52,751
YOU HAVE THE GOOD ENGAGEMENT

1047
00:35:52,751 --> 00:35:53,619
WITH THE EPIDEMIOLOGIST AND IN

1048
00:35:53,619 --> 00:35:55,387
DOING SO, YOU CAN BRING IN

1049
00:35:55,387 --> 00:35:56,421
MULTIPLE DIFFERENT TYPES OF DATA

1050
00:35:56,421 --> 00:36:01,460
AND TAKE THAT REALTIME OR NEAR

1051
00:36:01,460 --> 00:36:03,695
REALTIME PATHOGEN GENOMIC DATA,

1052
00:36:03,695 --> 00:36:04,730
CONTEXTURAL DATA, OTHER DATA

1053
00:36:04,730 --> 00:36:07,166
SOURCES AND USE THAT TO DERIVE

1054
00:36:07,166 --> 00:36:08,534
EFFECTIVE PUBLIC HEALTH ACTION.

1055
00:36:08,534 --> 00:36:10,502
FOR MOST OF WHAT WE DO IN PUBLIC

1056
00:36:10,502 --> 00:36:11,703
HEALTH, THIS NEEDS TO BE THE

1057
00:36:11,703 --> 00:36:13,205
NORTH STAR, WHAT IS THE PUBLIC

1058
00:36:13,205 --> 00:36:14,873
HEALTH OUTCOME THAT IS DESIRED,

1059
00:36:14,873 --> 00:36:16,408
HOW DO WE WORK BACKWARDS TO

1060
00:36:16,408 --> 00:36:20,712
FIGURE OUT WHAT DATA, HOW MUCH

1061
00:36:20,712 --> 00:36:22,681
DATA, THE TYPE AND GRANULARITY

1062
00:36:22,681 --> 00:36:25,350
OF THE TYPE THAT WE NEED TO GET

1063
00:36:25,350 --> 00:36:26,351
TO THAT POINT.

1064
00:36:26,351 --> 00:36:28,587
THE PAST FEW YEARS HAVE SEEN AN

1065
00:36:28,587 --> 00:36:30,856
EXPLOSION OF DIFFERENT SOURCES

1066
00:36:30,856 --> 00:36:33,492
FROM WHICH SEQUENCE DATA CAN BE

1067
00:36:33,492 --> 00:36:34,059
DERIVED.

1068
00:36:34,059 --> 00:36:35,360
WE'VE SEEN WASTE WATER

1069
00:36:35,360 --> 00:36:36,995
SURVEILLANCE REALLY TAKE OFF,

1070
00:36:36,995 --> 00:36:38,263
WASTE PAWRT MONITORING IS NOT

1071
00:36:38,263 --> 00:36:40,632
NEW, IT'S BEEN USE INDEED POLIO

1072
00:36:40,632 --> 00:36:42,701
SURVEILLANCES, MANY PEOPLE KNOW

1073
00:36:42,701 --> 00:36:44,770
FOR DECADES, THE EXPANSION INTO

1074
00:36:44,770 --> 00:36:46,371
THE NATIONAL WASTE WATER

1075
00:36:46,371 --> 00:36:49,007
SURVEILLANCE SYSTEM AND

1076
00:36:49,007 --> 00:36:50,876
EXPANSION GLOBALLY, INTO

1077
00:36:50,876 --> 00:36:52,377
INCORPORATING WASTE WATER, BASED

1078
00:36:52,377 --> 00:36:54,513
EPIDEMIOLOGY AS A MONITOR AND

1079
00:36:54,513 --> 00:36:56,682
STRATEGY REALLY PRESENTS AN

1080
00:36:56,682 --> 00:37:00,652
EXCITING NEW OPPORTUNITY FOR

1081
00:37:00,652 --> 00:37:01,486
POPULATION BASED SURVEILLANCE,

1082
00:37:01,486 --> 00:37:03,322
YOU KNOW ALTHOUGH I THINK--WHEN

1083
00:37:03,322 --> 00:37:05,090
THE DATA CAN BE INFORMATIVE WHEN

1084
00:37:05,090 --> 00:37:07,025
IT NEEDS TO BE INCORPORATED WITH

1085
00:37:07,025 --> 00:37:08,627
OTHER SOURCES OF DATA AND YOU

1086
00:37:08,627 --> 00:37:11,930
KNOW WHEN IT CAN POTENTIALLY NOT

1087
00:37:11,930 --> 00:37:13,932
BE AS HELPFUL AS IT COULD BE.

1088
00:37:13,932 --> 00:37:16,201
WE'VE SEEN ALSO THE

1089
00:37:16,201 --> 00:37:17,769
EXPANSION--I'M NOT GOING TO TALK

1090
00:37:17,769 --> 00:37:19,238
ABOUT THE TRAVELER GENOMIC

1091
00:37:19,238 --> 00:37:21,707
PROGRAM TODAY BUT LOOKING AT

1092
00:37:21,707 --> 00:37:24,176
SWABBING SOME OF THE NOT ONLY

1093
00:37:24,176 --> 00:37:26,745
WASTE WATER ON AIRCRAFTS BUT

1094
00:37:26,745 --> 00:37:27,913
SWABBING SOME OF THE TRAVELING

1095
00:37:27,913 --> 00:37:31,984
PUBLIC AND USING THAT AS THE WAY

1096
00:37:31,984 --> 00:37:33,986
TO FOR TRACE TRANSMISSION OF

1097
00:37:33,986 --> 00:37:35,254
SARS-COV-2 AND OTHER VIRUSES.

1098
00:37:35,254 --> 00:37:37,122
WE HAVE SEEN THIS IN MANY AREAS

1099
00:37:37,122 --> 00:37:39,324
OF HEALTH AND MANY REPOSITORIES

1100
00:37:39,324 --> 00:37:42,227
HAVE IT FROM HERE AND SPILL

1101
00:37:42,227 --> 00:37:43,495
OVERS, SPILL BACK, ALL THESE

1102
00:37:43,495 --> 00:37:48,967
NEED TO BE INCORPORATED INTO

1103
00:37:48,967 --> 00:37:49,701
VARIOUS STRATEGIES.

1104
00:37:49,701 --> 00:37:50,769
IDEALLY THOUGH YOU WANT TO MAKE

1105
00:37:50,769 --> 00:37:52,871
SURE YOU'RE DRIVING AS MUCH--AND

1106
00:37:52,871 --> 00:37:55,607
I REALIZE THAT NOT EVERY PUBLIC

1107
00:37:55,607 --> 00:37:56,575
HEALTH ENTITY, NOT EVERY

1108
00:37:56,575 --> 00:37:58,043
SUBMITTER WILL BE IN A POSITION

1109
00:37:58,043 --> 00:37:59,578
TO SUPPORT THIS BUT BEING ABLE

1110
00:37:59,578 --> 00:38:00,979
TO SUPPORT OPEN DATA AND OPEN

1111
00:38:00,979 --> 00:38:03,448
SCIENCE, THIS IS SOMETHING THAT

1112
00:38:03,448 --> 00:38:05,183
WE FEEL VERY STRONGLY ABOUT IN A

1113
00:38:05,183 --> 00:38:07,519
LOT OF THE U.S. PUBLIC HEALTH

1114
00:38:07,519 --> 00:38:08,287
DATA GENERATION, CREATING THIS

1115
00:38:08,287 --> 00:38:11,023
SORT OF DATA SHARING ECOSYSTEM,

1116
00:38:11,023 --> 00:38:11,890
REALLY DRIVES RESEARCH AND

1117
00:38:11,890 --> 00:38:17,562
INNOVATION AND I HAVE NO DOUBT,

1118
00:38:17,562 --> 00:38:18,997
THAT HOPEFULLY COUNTLESS

1119
00:38:18,997 --> 00:38:19,698
Ph.D.s AND GRADUATE WORK

1120
00:38:19,698 --> 00:38:22,601
WILL BE DONE ON THE BACKS OF A

1121
00:38:22,601 --> 00:38:24,236
LOT OF THE SEQUENCE DATA BEING

1122
00:38:24,236 --> 00:38:26,004
GENERATED BY U.S. PUBLIC HEALTH

1123
00:38:26,004 --> 00:38:27,739
LABS OVER THE COURSE OF THE PAST

1124
00:38:27,739 --> 00:38:28,340
FEW YEARS.

1125
00:38:28,340 --> 00:38:31,443
THAT OBVIOUSLY NEEDS TO BE TIED

1126
00:38:31,443 --> 00:38:33,745
INTO AN IMPORTANT CONVERSATION

1127
00:38:33,745 --> 00:38:35,247
AROUND ETHICS AND PATHOGEN

1128
00:38:35,247 --> 00:38:36,081
ACCESS AND BENEFIT SHARING BUT

1129
00:38:36,081 --> 00:38:38,050
YOU KNOW I THINK THERE'S

1130
00:38:38,050 --> 00:38:38,817
TREMENDOUS VALUE IN OPEN DATA

1131
00:38:38,817 --> 00:38:41,987
AND I THINK THERE'S WAYS TO DO

1132
00:38:41,987 --> 00:38:44,556
IT RESPONSIBLY WHILE STILL

1133
00:38:44,556 --> 00:38:46,591
ALLOWING INITIAL SUBMITTERS TO

1134
00:38:46,591 --> 00:38:48,760
HAVE FULL ACADEMIC LICENSE TO

1135
00:38:48,760 --> 00:38:50,295
TAKE ADVANTAGE OF A LOT OF THE

1136
00:38:50,295 --> 00:38:52,164
CONTEXT AND STORY THAT

1137
00:38:52,164 --> 00:38:52,898
THEY--THAT ONLY THEY CAN TELL

1138
00:38:52,898 --> 00:38:54,433
AND TO BE ABLE IT ACTUALLY PUT

1139
00:38:54,433 --> 00:38:58,270
THOSE DATA OUT THERE.

1140
00:38:58,270 --> 00:39:00,906
SO IF YOU DO THIS RIGHT, IT

1141
00:39:00,906 --> 00:39:02,240
HELPS INFORM BETTER STRATEGIES,

1142
00:39:02,240 --> 00:39:05,143
IT HELPS YOU DEFINE WHERE YOU

1143
00:39:05,143 --> 00:39:06,945
NEED TECHNOLOGICAL IMPROVEMENT,

1144
00:39:06,945 --> 00:39:09,982
IT HELPS YOU IDENTIFY NEW

1145
00:39:09,982 --> 00:39:11,483
APPROACHES FOR DIAGNOSTICS, NEW

1146
00:39:11,483 --> 00:39:12,351
TARGETS OR EVALUATE THE 1S THAT

1147
00:39:12,351 --> 00:39:14,953
ARE OUT THERE AND HELPS YOU

1148
00:39:14,953 --> 00:39:17,522
REFINE AND MODEL YOUR

1149
00:39:17,522 --> 00:39:19,024
SURVEILLANCE, UNDERSTANDING HOW

1150
00:39:19,024 --> 00:39:20,158
TO SCALE SURVEILLANCE, AND WHERE

1151
00:39:20,158 --> 00:39:21,226
YOU NEEDED THE DEFINITE

1152
00:39:21,226 --> 00:39:25,197
APPROACHES AND THE DIFFERENT

1153
00:39:25,197 --> 00:39:25,897
MOLECULAR TECHNIQUES.

1154
00:39:25,897 --> 00:39:27,332
ONE OF THE EMERGES REALITIES IS,

1155
00:39:27,332 --> 00:39:28,834
YOU KNOW WE ALSO HAVE TO THINK

1156
00:39:28,834 --> 00:39:30,435
ABOUT HOW CLINICAL AND REFERENCE

1157
00:39:30,435 --> 00:39:32,104
REPORTING FITS INTO THIS, WITH

1158
00:39:32,104 --> 00:39:36,441
SOME OF THE UPCOMING POTENTIAL

1159
00:39:36,441 --> 00:39:38,710
CHANGES AROUND LDTs, WITH

1160
00:39:38,710 --> 00:39:42,447
ONGOING CONVERSATIONS AROUND THE

1161
00:39:42,447 --> 00:39:45,417
USE OF PATHOGENIC, METHON DONNIC

1162
00:39:45,417 --> 00:39:47,519
METHODS AND CLIA AND OTHER

1163
00:39:47,519 --> 00:39:48,754
CREDITED FACILITIES WE NEED TO

1164
00:39:48,754 --> 00:39:50,422
MAKE SURE AS WE BUILD THESE

1165
00:39:50,422 --> 00:39:51,823
SYSTEMS, BUILD THESE DATABASES,

1166
00:39:51,823 --> 00:39:55,260
AS WE THINK ABOUT HOW THIS

1167
00:39:55,260 --> 00:39:56,661
CONTINUUM WORKS, THERE NEEDS TO

1168
00:39:56,661 --> 00:39:58,730
BE THE NECESSARY AUDITTABILITY

1169
00:39:58,730 --> 00:40:01,700
AND CONTROLS BUILT IN TO BE

1170
00:40:01,700 --> 00:40:03,769
COMPLIANT WITH REGULATORY

1171
00:40:03,769 --> 00:40:04,636
REPORTING REQUIREMENTS.

1172
00:40:04,636 --> 00:40:06,905
ALL OF THIS, YOU KNOW REQUIRES

1173
00:40:06,905 --> 00:40:09,775
ONGOING INVESTMENT IN PEOPLE, IN

1174
00:40:09,775 --> 00:40:11,910
INFRASTRUCTURE AND TECHNOLOGY,

1175
00:40:11,910 --> 00:40:15,080
AND SYSTEMS, GOVERNANCE FOR

1176
00:40:15,080 --> 00:40:18,183
SURE, QUALITY IS USUALLY

1177
00:40:18,183 --> 00:40:18,750
SOMETIMES, MAYBE--MAYBE

1178
00:40:18,750 --> 00:40:20,852
SOMETIMES AN AFTER THOUGHT BUT

1179
00:40:20,852 --> 00:40:22,187
NEEDS TO ENGRAINED IN ALL LEVELS

1180
00:40:22,187 --> 00:40:23,789
OF THIS, BUT YOU KNOW I THINK

1181
00:40:23,789 --> 00:40:25,490
WE'VE SEEN THE VALUE OF BRINGING

1182
00:40:25,490 --> 00:40:28,427
IN MIEW PARTNERS, FRESH THINKING

1183
00:40:28,427 --> 00:40:30,595
ON THIS, AND REALLY TAKING

1184
00:40:30,595 --> 00:40:35,634
ADVANTAGE OF THE SYNERGYS THAT

1185
00:40:35,634 --> 00:40:36,168
THAT BRINGS.

1186
00:40:36,168 --> 00:40:37,669
SO I'M GOING TO FAST FORWARD

1187
00:40:37,669 --> 00:40:39,404
THROUGH THIS IN THE INTEREST OF

1188
00:40:39,404 --> 00:40:40,672
TIME, 1 THING I WANT TO

1189
00:40:40,672 --> 00:40:42,074
HIGHLIGHT THOUGH IS THERE ARE

1190
00:40:42,074 --> 00:40:44,342
LOTS OF DIFFERENT CHALLENGES AT

1191
00:40:44,342 --> 00:40:46,244
EVERY SINGLE PHASE OF GENOMIC

1192
00:40:46,244 --> 00:40:48,980
SURVEILLANCE BUT THERE ARE 2

1193
00:40:48,980 --> 00:40:50,115
IMPORTANT TRUTHS.

1194
00:40:50,115 --> 00:40:51,783
ONE THESE ARE VERY UNIVERSAL,

1195
00:40:51,783 --> 00:40:53,718
THEY ARE APPLIED TO VETERINARY

1196
00:40:53,718 --> 00:40:54,986
COMMUNITIUALLY ANY PATHOGEN

1197
00:40:54,986 --> 00:40:56,254
WE'RE INTERESTED IN AND

1198
00:40:56,254 --> 00:40:57,089
SURVEILLING FOR.

1199
00:40:57,089 --> 00:40:58,623
THE ACTUAL NUANCE AND SPECIFICS

1200
00:40:58,623 --> 00:41:00,025
OF THE CHALLENGES MAY DIFFER A

1201
00:41:00,025 --> 00:41:03,562
LITTLE BIT, BUT A LOT OF THEM

1202
00:41:03,562 --> 00:41:07,599
ARE VERY SOLVABLE IF WE WORK

1203
00:41:07,599 --> 00:41:10,102
ACROSS IN SORT OF A CROSS

1204
00:41:10,102 --> 00:41:10,669
CUTTING WAY.

1205
00:41:10,669 --> 00:41:14,439
THE OTHER PIECE IS THAT THIS

1206
00:41:14,439 --> 00:41:16,641
JUST DOESN'T APPLY TO U.S. LABS

1207
00:41:16,641 --> 00:41:18,143
OR WELL RESOURCED U.S. LABS,

1208
00:41:18,143 --> 00:41:21,313
THESE ARE UNIVERSAL TRUTHS,

1209
00:41:21,313 --> 00:41:22,581
UNIVERSAL CHALLENGES, ALSO

1210
00:41:22,581 --> 00:41:23,982
UNIVERSAL OPPORTUNITIES, AS WE

1211
00:41:23,982 --> 00:41:27,085
LOOK AT THE CHALLENGES AROUND

1212
00:41:27,085 --> 00:41:30,388
THE WORKFORCE, AROUND CAPACITY

1213
00:41:30,388 --> 00:41:31,323
DEVELOPMENT, AROUND INSURING

1214
00:41:31,323 --> 00:41:32,624
NECESSARY QUALITY SYSTEMS AND IT

1215
00:41:32,624 --> 00:41:34,159
IN PLACE, AS WE BUILD THE

1216
00:41:34,159 --> 00:41:36,928
NECESSARY TOOLS FOR REPORTING

1217
00:41:36,928 --> 00:41:38,230
AND DATA INTEGRATION, THESE ARE

1218
00:41:38,230 --> 00:41:39,731
CHALLENGES THAT ARE SHARED BY A

1219
00:41:39,731 --> 00:41:43,001
LOT OF OUR GLOBAL PARTNERS AND

1220
00:41:43,001 --> 00:41:44,803
IN MANY CASES MANY OF OUR GLOBAL

1221
00:41:44,803 --> 00:41:46,438
PARTNERS HAVE COME UP WITH

1222
00:41:46,438 --> 00:41:48,607
REALLY EVENNIVE WAYS OF

1223
00:41:48,607 --> 00:41:49,741
ADDRESSING THESE CHALLENGES SO I

1224
00:41:49,741 --> 00:41:52,878
THINK WE'RE IN A UNIQUE POINT IN

1225
00:41:52,878 --> 00:41:54,613
LABORATORY METHOD ANDS PUBLIC

1226
00:41:54,613 --> 00:41:56,982
HEALTH DEVELOPMENT WHERE I THINK

1227
00:41:56,982 --> 00:41:59,050
THERE'S AN OPPORTUNITY FOR REAL

1228
00:41:59,050 --> 00:42:00,552
GLOBAL CONVERSATION AROUND SOME

1229
00:42:00,552 --> 00:42:03,555
OF THESE CHALLENGES, HOW WE CAN

1230
00:42:03,555 --> 00:42:04,156
IMPROVE THEM, IMPROVE

1231
00:42:04,156 --> 00:42:04,956
INTEROPERABILITY AND HOW

1232
00:42:04,956 --> 00:42:08,493
TOGETHER WE CAN SOLVE SOME OF

1233
00:42:08,493 --> 00:42:08,927
THE CHALLENGES.

1234
00:42:08,927 --> 00:42:10,428
SO IN THE TIME THAT REMAINS I

1235
00:42:10,428 --> 00:42:11,830
WANT TO TALK A LITTLE BIT ABOUT

1236
00:42:11,830 --> 00:42:14,032
THE FUTURE--POTENTIAL XUR KIND

1237
00:42:14,032 --> 00:42:14,799
OF WHAT THIS BRINGS.

1238
00:42:14,799 --> 00:42:18,270
A LOT OF WHAT I TALKED ABOUT IS

1239
00:42:18,270 --> 00:42:19,437
THE NEW PARTNERSHIPS ISSUES THE

1240
00:42:19,437 --> 00:42:21,540
ROLE OF NEW PARTNERSHIPS, THE

1241
00:42:21,540 --> 00:42:23,108
IMPACT THAT HAS HAD AND LESSONS

1242
00:42:23,108 --> 00:42:24,476
LEARNED FROM THAT, I WANT TO

1243
00:42:24,476 --> 00:42:26,811
TAKE US BACK NOW TO TALK ABOUT

1244
00:42:26,811 --> 00:42:28,480
HOW WE APPROACHED THE REGIONAL

1245
00:42:28,480 --> 00:42:30,081
MODELS IN THE PROBLEM OF

1246
00:42:30,081 --> 00:42:31,249
IMPLEMENTING TECHNOLOGIES AND

1247
00:42:31,249 --> 00:42:32,417
PUBLIC HEALTH AND A LITTLE BIT

1248
00:42:32,417 --> 00:42:34,953
ABOUT WHERE WE'RE GOING IN THE

1249
00:42:34,953 --> 00:42:35,220
FUTURE.

1250
00:42:35,220 --> 00:42:37,022
SO FIELD FUNCTIONS GO BACK UP,

1251
00:42:37,022 --> 00:42:40,258
ABOUT 5 OR 6 YEARS, WE HAD TAKEN

1252
00:42:40,258 --> 00:42:42,360
AMD TAKEN A REGIONAL MODEL TO

1253
00:42:42,360 --> 00:42:44,663
BUILDING THIS KIND OF

1254
00:42:44,663 --> 00:42:47,098
CAPACITY,RY WEALZ WE COULD BT

1255
00:42:47,098 --> 00:42:49,067
PUT A BIOINFORMATITION AND

1256
00:42:49,067 --> 00:42:50,001
GENOMIC EPIDEMIOLOGIST IN EVERY

1257
00:42:50,001 --> 00:42:51,303
SINGLE STATE ASK LOCAL PUBLIC

1258
00:42:51,303 --> 00:42:52,137
HEALTH DEPARTMENT IN THE COUNTRY

1259
00:42:52,137 --> 00:42:54,472
BUT WE COULD AT LEAST TAKE A

1260
00:42:54,472 --> 00:42:56,541
REGIONAL APPROACH TO THIS AND

1261
00:42:56,541 --> 00:42:59,411
START FUNDING THESE POSITIONS TO

1262
00:42:59,411 --> 00:43:00,378
HELP IDENTIFY REGIONAL

1263
00:43:00,378 --> 00:43:03,148
PRIORITIES TO ACT AS A REGIONAL

1264
00:43:03,148 --> 00:43:03,982
TECHNIICAL RESOURCE AND HELP

1265
00:43:03,982 --> 00:43:06,851
DESK IN SOME CASES AND TO HELP

1266
00:43:06,851 --> 00:43:09,020
IDENTIFY, PLAN AND EVALUATE

1267
00:43:09,020 --> 00:43:11,156
THINGS LIKE TRAINING AND

1268
00:43:11,156 --> 00:43:11,890
CAPACITY BELLING.

1269
00:43:11,890 --> 00:43:13,491
THIS HELPED US NOT ONLY HAVE

1270
00:43:13,491 --> 00:43:17,729
PEOPLE IN THE FIELD THAT COULD

1271
00:43:17,729 --> 00:43:18,897
ACTUALLY PRACTICALLY AND

1272
00:43:18,897 --> 00:43:20,165
HANDS-ON WORK ON THESE

1273
00:43:20,165 --> 00:43:21,666
CHALLENGES BUT ALSO TO HELP US

1274
00:43:21,666 --> 00:43:26,404
PRIORITIZE WHERE WE NEEDED TO

1275
00:43:26,404 --> 00:43:34,713
MAKE OR TO FOCUS OUR EFFORTS AND

1276
00:43:34,713 --> 00:43:35,280
RESOURCES.

1277
00:43:35,280 --> 00:43:37,349
THE PAST FEW YEARS GIVEN AN

1278
00:43:37,349 --> 00:43:40,585
INJECTION OF FUNDING TO BUILD

1279
00:43:40,585 --> 00:43:41,219
GENOMIC SURVEILLANCE IT ALLOWED

1280
00:43:41,219 --> 00:43:42,887
US TO MAKE INVESTMENTS IN STATE

1281
00:43:42,887 --> 00:43:44,856
AND LOCAL HEALTH DEPARTMENTS, SO

1282
00:43:44,856 --> 00:43:46,157
MANY HAVE HAD THE OPPORTUNITY TO

1283
00:43:46,157 --> 00:43:49,561
BUILD STRONGER AND MORE ADAPT

1284
00:43:49,561 --> 00:43:50,862
BELIEVE INFRASTRUCTURE, HIRE

1285
00:43:50,862 --> 00:43:52,697
MORE LABORATORY STAFF,

1286
00:43:52,697 --> 00:43:55,033
SPECIALIZED LABORATORY STAFF TO

1287
00:43:55,033 --> 00:43:56,201
START BUILDING BIO-INFORMATICS

1288
00:43:56,201 --> 00:43:59,804
TEAMS AND STRENGTHENING GENOMIC

1289
00:43:59,804 --> 00:44:01,106
EPIDEMIOLOGY GROUPS ACROSS

1290
00:44:01,106 --> 00:44:03,475
THEIR--CROSS THEIR HEALTH

1291
00:44:03,475 --> 00:44:03,775
DEPARTMENTS.

1292
00:44:03,775 --> 00:44:08,446
THIS IS TRUE YOU KNOW FOR

1293
00:44:08,446 --> 00:44:08,680
 LARGE

1294
00:44:08,680 --> 00:44:10,282
STATES AND IT'S ALSO TRUE FOR

1295
00:44:10,282 --> 00:44:11,916
SMALL COUNTY AND LOCAL HEALTH

1296
00:44:11,916 --> 00:44:14,552
DEPARTMENTS THAT HAVE TAKEN

1297
00:44:14,552 --> 00:44:15,820
ADVANTAGE OF THIS INFLUX OF

1298
00:44:15,820 --> 00:44:17,122
RESOURCES TO HELP AND GUIDE AND

1299
00:44:17,122 --> 00:44:18,290
START BUILD THIS CAPABILITY.

1300
00:44:18,290 --> 00:44:21,459
SO SOME OF THIS WAS THINGS LIKE

1301
00:44:21,459 --> 00:44:22,260
CAPITAL INVESTMENTS, INSURING WE

1302
00:44:22,260 --> 00:44:25,363
HAVE THE NECESSARY BUILDINGS AND

1303
00:44:25,363 --> 00:44:27,532
YOU KNOW FACILITIES TO ACTUALLY

1304
00:44:27,532 --> 00:44:29,734
SUPPORT THESE KINDS OF

1305
00:44:29,734 --> 00:44:31,102
INSTRUMENTATION, THESE KINDS OF

1306
00:44:31,102 --> 00:44:31,436
DATA DEMANDS.

1307
00:44:31,436 --> 00:44:34,506
SOME OF IT IS INVESTMENTS IN

1308
00:44:34,506 --> 00:44:36,374
LABORATORY TECHNOLOGY ITSELF,

1309
00:44:36,374 --> 00:44:37,776
INCLUDING AUTOMATION, MAKING

1310
00:44:37,776 --> 00:44:39,344
SURE THAT SAMPLE PROCESSING CAN

1311
00:44:39,344 --> 00:44:39,811
PROCEED TO PAY.

1312
00:44:39,811 --> 00:44:42,781
BUT A LOT OF IT IS IN BUILDING

1313
00:44:42,781 --> 00:44:43,615
THE NECESSARY WORKFORCE TO

1314
00:44:43,615 --> 00:44:45,483
ACTUALLY DO THE WORK AND TO MAKE

1315
00:44:45,483 --> 00:44:48,653
SURE THAT WE ACTUALLY HAVE

1316
00:44:48,653 --> 00:44:50,522
HIGHLY SKILLED PEOPLE IN ALL THE

1317
00:44:50,522 --> 00:44:51,556
PLACES THAT WE ACTUALLY NEED

1318
00:44:51,556 --> 00:44:52,891
THEM ACROSS THE PUBLIC HEALTH

1319
00:44:52,891 --> 00:44:57,829
SYSTEM IN ORDER TO MAKE THIS

1320
00:44:57,829 --> 00:44:58,029
WORK.

1321
00:44:58,029 --> 00:44:59,164
IT'S ALSO ALLOWED US TO PUSH

1322
00:44:59,164 --> 00:45:00,098
DOWN THE LESSONS FROM THE

1323
00:45:00,098 --> 00:45:01,533
SPHERES TO THE STATE AND LOCAL

1324
00:45:01,533 --> 00:45:01,733
LEVEL.

1325
00:45:01,733 --> 00:45:03,101
WE'RE DOING A LOT OF THINGS, WE

1326
00:45:03,101 --> 00:45:05,870
WILL TALK ABOUT A FEW HOPEFULLY

1327
00:45:05,870 --> 00:45:08,073
IN A MINUTE, ABOUT BUILDING THIS

1328
00:45:08,073 --> 00:45:09,307
REACTION SERVICE BETWEEN

1329
00:45:09,307 --> 00:45:10,408
ACADEMIA AND THE PRIVATE SECTOR,

1330
00:45:10,408 --> 00:45:11,976
AND THAT CONTINUES TO BE AN

1331
00:45:11,976 --> 00:45:12,711
IMPORTANT THEME.

1332
00:45:12,711 --> 00:45:14,779
HOW CAN WE CONTINUE TO

1333
00:45:14,779 --> 00:45:16,881
STRENGTHEN THIS, HOW CAN WE

1334
00:45:16,881 --> 00:45:21,019
INSURE THAT GRADUATES FROM THE

1335
00:45:21,019 --> 00:45:22,020
ACADEMIC PROGRAMS CONSIDER

1336
00:45:22,020 --> 00:45:24,122
PUBLIC HEALTH IS NOT AN

1337
00:45:24,122 --> 00:45:25,757
ALTERNATIVE CAREER BUT PERHAPS A

1338
00:45:25,757 --> 00:45:26,591
VITAL AND INTERESTING CAREER

1339
00:45:26,591 --> 00:45:27,892
PATH THAT THEY MIGHT CONSIDER

1340
00:45:27,892 --> 00:45:31,396
FROM DAY 1 OF THEIR PROGRAMS.

1341
00:45:31,396 --> 00:45:33,231
IT ALSO ALLOWS US TO INSURE THAT

1342
00:45:33,231 --> 00:45:36,434
A LOT OF THESEITATE AND LOCAL

1343
00:45:36,434 --> 00:45:37,502
PUBLIC HEALTH DEPARTMENTS HAVE

1344
00:45:37,502 --> 00:45:39,704
ACCESS TO THESE PLATFORMS,

1345
00:45:39,704 --> 00:45:41,706
WHETHER IT'S FEDERALLY FUNDED,

1346
00:45:41,706 --> 00:45:42,340
COORDINATED SURVEILLANCE TOOLS

1347
00:45:42,340 --> 00:45:44,943
OR WHETHER THAT IS NEW DATA

1348
00:45:44,943 --> 00:45:46,211
DASHBOARDS, NEW DATA INTEGRATION

1349
00:45:46,211 --> 00:45:47,645
BOARDS THAT ALLOW THEM TO DO

1350
00:45:47,645 --> 00:45:48,446
THEIR WORK MORE EFFECTIVE

1351
00:45:48,446 --> 00:45:50,148
LOAMACYY AND SHARE THE DATA MORE

1352
00:45:50,148 --> 00:45:51,516
EFFECTIVELY AMONG THEIR TEAMS,

1353
00:45:51,516 --> 00:45:54,586
ALL OF THESE HAVE REALLY BECOME

1354
00:45:54,586 --> 00:45:57,422
POSSIBLE AND YOU KNOW OUR FED BY

1355
00:45:57,422 --> 00:45:58,723
NOT ONLY THESE INVESTMENTS BUT A

1356
00:45:58,723 --> 00:46:02,961
LOT OF THE PARTNERSHIPS THAT

1357
00:46:02,961 --> 00:46:03,828
COME WITH IT.

1358
00:46:03,828 --> 00:46:05,263
WE ALSO USE BROAD AGENCY

1359
00:46:05,263 --> 00:46:06,564
ANNOUNCE WANTS PRETTY

1360
00:46:06,564 --> 00:46:08,366
EFFECTIVELY, BEFORE 2020 WE USED

1361
00:46:08,366 --> 00:46:09,934
EXACTLY 1 BROAD AGENCY

1362
00:46:09,934 --> 00:46:10,268
ANNOUNCEMENT.

1363
00:46:10,268 --> 00:46:14,372
WE USED IT TO DEVELOP A SET OF

1364
00:46:14,372 --> 00:46:16,341
TOOLS WITH THE CDPS, OR THE

1365
00:46:16,341 --> 00:46:18,143
OXFORD BIG DATA INSTITUTE, SET

1366
00:46:18,143 --> 00:46:19,878
OF TOOLS CALLED DATA FLOW WHICH

1367
00:46:19,878 --> 00:46:22,814
REALLY ACT AS AN ETL LAYER FOR

1368
00:46:22,814 --> 00:46:23,848
METADATA AND DATA

1369
00:46:23,848 --> 00:46:24,282
TRANSFORMATION.

1370
00:46:24,282 --> 00:46:27,385
OVER THE COURSE OF THE PANDEMIC,

1371
00:46:27,385 --> 00:46:32,724
WE PUT OUT 44 ADDITIONAL VA

1372
00:46:32,724 --> 00:46:35,093
PROJECTS OR 45 BAA PROJECTS, IN

1373
00:46:35,093 --> 00:46:39,164
THE EARLY DAYS THIS WAS IN SOME

1374
00:46:39,164 --> 00:46:41,399
WAYS BOLSTERED OUR SARS-COV-2

1375
00:46:41,399 --> 00:46:42,534
SURVEILLANCE ACTIVITIES, IT HAD

1376
00:46:42,534 --> 00:46:44,068
A MECHANISM THAT COULD SUPPORT

1377
00:46:44,068 --> 00:46:45,837
CLINICAL EFFORTS THAT WERE

1378
00:46:45,837 --> 00:46:47,539
PROVIDING USEFUL DATA AND INPUT.

1379
00:46:47,539 --> 00:46:49,340
AS TIME WENT ON, IT STARTED TO

1380
00:46:49,340 --> 00:46:53,278
FOCUS MORE ON SARS-COV-2 VARIANT

1381
00:46:53,278 --> 00:46:55,013
CHARACTERIZATION AND ANALYSIS,

1382
00:46:55,013 --> 00:46:56,714
UNDERSTANDING VACCINE EFFICACY

1383
00:46:56,714 --> 00:46:57,782
AND OTHER IMPORTANT

1384
00:46:57,782 --> 00:47:02,454
CHEARKTISTICS AS THEY CAME

1385
00:47:02,454 --> 00:47:03,354
ALONG.

1386
00:47:03,354 --> 00:47:05,223
IT'S SINCE BROADENED WE'VE HAD

1387
00:47:05,223 --> 00:47:09,194
INCREASED FOCUS AND RECENT

1388
00:47:09,194 --> 00:47:11,896
SOLICITATIONS ON BIO-INFORMATICS

1389
00:47:11,896 --> 00:47:14,933
SOFTWARE, TOOLS FOR N AND FILE O

1390
00:47:14,933 --> 00:47:16,267
DYNAMIC ANALYSIS AND WASTE WATER

1391
00:47:16,267 --> 00:47:19,037
AND ANALYSIS TOOLS AND IN OUR

1392
00:47:19,037 --> 00:47:20,305
MOST RECENT SOLICITATION, WHICH

1393
00:47:20,305 --> 00:47:22,707
IS ACTUALLY CLOSING THIS FROM A

1394
00:47:22,707 --> 00:47:27,312
LOT OF IT IS FOCUSED ON

1395
00:47:27,312 --> 00:47:32,650
PATHOGENIC AGNOSTIC AND/OR

1396
00:47:32,650 --> 00:47:34,919
METAAND REALLY TRYING TO PUSH

1397
00:47:34,919 --> 00:47:35,487
THE INFOIVATION ENVELOPE A

1398
00:47:35,487 --> 00:47:38,756
LITTLE BIT BUT TO DO SO IN A WAY

1399
00:47:38,756 --> 00:47:40,692
THAT IS CONDUCTED BACK TO STATE

1400
00:47:40,692 --> 00:47:42,961
AND FEDERAL PUBLIC HEALTH.

1401
00:47:42,961 --> 00:47:45,096
A LOT OF THING VS COME OUT OF

1402
00:47:45,096 --> 00:47:50,268
THE VAs, SOME OF THIS SOME OF

1403
00:47:50,268 --> 00:47:51,436
THIS IS RESEARCH AROUND

1404
00:47:51,436 --> 00:47:52,971
SARS-COV-2 EXPW I SHOULD COME UP

1405
00:47:52,971 --> 00:47:54,172
WITH A PUBLICATION LIST OF

1406
00:47:54,172 --> 00:47:55,273
EVERYTHING THAT'S SUPPORTED AS A

1407
00:47:55,273 --> 00:47:56,808
RESULT OF THIS, IT ALLOWED FOR

1408
00:47:56,808 --> 00:47:57,475
THE DEVELOPMENT AND

1409
00:47:57,475 --> 00:47:58,943
IMPLEMENTATION OF A LOT OF NEW

1410
00:47:58,943 --> 00:48:00,578
TOOLS AND CAPABILITIES AS I

1411
00:48:00,578 --> 00:48:01,646
SAID, YOU KNOW, THE

1412
00:48:01,646 --> 00:48:02,614
IMPLEMENTATION OF SOME OF THESE

1413
00:48:02,614 --> 00:48:06,451
TOOLS AT THE STATE AND LOCAL

1414
00:48:06,451 --> 00:48:07,385
PUBLIC HEALTH DEPARTMENT HAS

1415
00:48:07,385 --> 00:48:09,387
CHANGED THEIR ABILITY TO USE IT

1416
00:48:09,387 --> 00:48:11,222
EFFECTIVELY AND TO INCORPORATE

1417
00:48:11,222 --> 00:48:18,530
THAT NOT ONLY IN THE SARS-COV-2

1418
00:48:18,530 --> 00:48:19,097
RESPONSE AS WELL.

1419
00:48:19,097 --> 00:48:22,066
A LOT OF THESE ARE PARTIAL

1420
00:48:22,066 --> 00:48:23,368
SUPPORT AND DEVELOPMENT OF THE

1421
00:48:23,368 --> 00:48:24,969
LOT OF THE NEW TOOLS FOR

1422
00:48:24,969 --> 00:48:35,513
DENATIONAL LIBRARY OF MEDICINIC

1423
00:48:36,681 --> 00:48:38,416
EPIDEMIOLOGY--TOOLS LIKE THE

1424
00:48:38,416 --> 00:48:39,450
UPDATER LYING INFRASTRUCTURE

1425
00:48:39,450 --> 00:48:41,986
HAVE BEEN DEVELOPED AND ARE

1426
00:48:41,986 --> 00:48:44,389
INDISPENSABLE AS WELL AS NEW

1427
00:48:44,389 --> 00:48:46,024
VISUALIZATION TOOLS THAT ALLOW

1428
00:48:46,024 --> 00:48:49,093
FOR RAPID INTERPRETATION OF

1429
00:48:49,093 --> 00:48:49,327
DATA.

1430
00:48:49,327 --> 00:48:51,362
SOME OF THIS HAS HELPED FILL

1431
00:48:51,362 --> 00:48:54,232
GAPS, A SINGLE BAA PROJECT WAS

1432
00:48:54,232 --> 00:48:55,533
RESPONSIBLE FOR OVER HALF OF THE

1433
00:48:55,533 --> 00:48:57,268
SEQUENCES THAT WERE GENERATED

1434
00:48:57,268 --> 00:48:59,103
FROM A SINGLE UNDERREPRESENTED

1435
00:48:59,103 --> 00:49:00,972
STATE, YOU KNOW THE STATE PUBLIC

1436
00:49:00,972 --> 00:49:02,507
HEALTH DEPARTMENT JUST WAS

1437
00:49:02,507 --> 00:49:03,775
HAVING CHALLENGES GETTING HANDS

1438
00:49:03,775 --> 00:49:14,185
ON THE NECESSARY SAMPLES

1439
00:49:25,930 --> 00:49:34,839
EMPLOY--MULTISTATE REGIONAL

1440
00:49:34,839 --> 00:49:37,809
CLINICAL VIERPTS THIS IS A POST

1441
00:49:37,809 --> 00:49:39,210
MASTERS POST DOCTORAL FELLOWSHIP

1442
00:49:39,210 --> 00:49:40,244
PROGRAM, IT'S BEEN AN

1443
00:49:40,244 --> 00:49:41,879
OPPORTUNITY FOR US TO USE A TOOL

1444
00:49:41,879 --> 00:49:43,414
OR PLATFORMS LIKE SPHERES TO

1445
00:49:43,414 --> 00:49:46,050
ADVERTISE FOR THESE KINDS OF

1446
00:49:46,050 --> 00:49:47,885
OPPORTUNITIES, WE RECENTLY

1447
00:49:47,885 --> 00:49:49,320
ENTERED INTO PARTNERSHIP 2 WITH

1448
00:49:49,320 --> 00:49:52,123
THE FERGUSON FELLOWSHIP PROGRAM

1449
00:49:52,123 --> 00:49:53,291
WHICH SPECIFICALLY, NOT

1450
00:49:53,291 --> 00:49:56,127
SPECIFICALLY BUT IT HELPS TO

1451
00:49:56,127 --> 00:50:01,099
BUILD YOU KNOW UNDERREPRESENTED

1452
00:50:01,099 --> 00:50:02,834
GROUPS WITHIN PUBLIC HEALTH TO

1453
00:50:02,834 --> 00:50:04,469
MATCH THOSE AND WE'RE STARTING

1454
00:50:04,469 --> 00:50:06,838
TO BUILD OUT A RECRUITMENT

1455
00:50:06,838 --> 00:50:09,340
INFRASTRUCTURE TO MAKE SURE WE

1456
00:50:09,340 --> 00:50:10,041
ACTUALLY--I SAID INFRASTRUCTURE

1457
00:50:10,041 --> 00:50:12,043
A LOT, A RECRUITMENT FOUNDATION

1458
00:50:12,043 --> 00:50:13,978
THAT ALLOWS US TO BRING IN A LOT

1459
00:50:13,978 --> 00:50:15,446
OF DIFFERENT PEOPLE FROM

1460
00:50:15,446 --> 00:50:17,849
DEFINITE BACKGROUNDS AND

1461
00:50:17,849 --> 00:50:19,951
DIFFERENT SKILL SETS AND CAN

1462
00:50:19,951 --> 00:50:21,352
HELP BUILD OUT BIO-INFORMATICS

1463
00:50:21,352 --> 00:50:31,763
BUT GENOMIC AND EPIY AND

1464
00:50:34,332 --> 00:50:35,333
LABORATORY TECHNIQUE.

1465
00:50:35,333 --> 00:50:37,101
THE MAJORITY OF THEM NOW

1466
00:50:37,101 --> 00:50:38,169
AREITATE AND LOCAL HEALTH, PUB

1467
00:50:38,169 --> 00:50:40,204
LIBRARY FOUNDATION HEALTH LABS

1468
00:50:40,204 --> 00:50:41,706
SO FAR AND 3 COUNTY AND LOCAL

1469
00:50:41,706 --> 00:50:43,007
BUT A MAJORITY OF THEM HAVE

1470
00:50:43,007 --> 00:50:44,542
STAYED ON IN PUBLIC HEALTH

1471
00:50:44,542 --> 00:50:47,578
CAREERS WHICH IS A CRITICAL

1472
00:50:47,578 --> 00:50:50,481
OUTCOME, 71% HAVE STAYED IN

1473
00:50:50,481 --> 00:50:52,116
PUBLIC HEALTH AT SOME LEVEL AND

1474
00:50:52,116 --> 00:50:54,419
IF YOU LOOK AT THE FIRST 5

1475
00:50:54,419 --> 00:50:55,953
COHORTS OVER HALF WHICH IS

1476
00:50:55,953 --> 00:50:57,321
REALLY A FANTASTIC OUTCOME FOR

1477
00:50:57,321 --> 00:50:57,488
US.

1478
00:50:57,488 --> 00:51:01,426
SO THE LAST THING I WANT TO TALK

1479
00:51:01,426 --> 00:51:05,697
ABOUT I THINK IS THE PATHOGEN

1480
00:51:05,697 --> 00:51:07,765
GENOMICS CENTERS OF EXCELLENCE.

1481
00:51:07,765 --> 00:51:08,800
THIS IS A OPPORTUNITY FOR US TO

1482
00:51:08,800 --> 00:51:10,501
BUILD ON THE ACADEMIC

1483
00:51:10,501 --> 00:51:12,303
PARTNERSHIPS THRA WE STARTED TO

1484
00:51:12,303 --> 00:51:13,504
FORGE THROUGH SPHERES, EACH 1 OF

1485
00:51:13,504 --> 00:51:15,907
THE 5 SITES ACROSS THE U.S.

1486
00:51:15,907 --> 00:51:17,542
IS--I WILL SWITCH TO THE NEXT

1487
00:51:17,542 --> 00:51:22,647
LIED IS A PARTNERSHIP BETWEEN

1488
00:51:22,647 --> 00:51:23,614
THE STATE PUBLIC HEALTH

1489
00:51:23,614 --> 00:51:24,682
DEPARTMENT AS THE RECIPIENT AND

1490
00:51:24,682 --> 00:51:28,219
1 OR MORE ACADEMIC INSTITUTIONS,

1491
00:51:28,219 --> 00:51:30,188
THESE GROUPS HAVE INDIVIDUAL

1492
00:51:30,188 --> 00:51:31,622
PORTFOLIOS THAT FOCUS ON

1493
00:51:31,622 --> 00:51:33,324
SPECIFIC PATHOGENS AND

1494
00:51:33,324 --> 00:51:34,358
APPLICATIONS, THERE'S ALSO A

1495
00:51:34,358 --> 00:51:36,994
NUMBER OF NETWORK EFFECTS, AND

1496
00:51:36,994 --> 00:51:39,063
FROM THIS WE'RE TRYING TO DRIVE

1497
00:51:39,063 --> 00:51:40,364
NOT ONLY INNOVATION AND PUBLIC

1498
00:51:40,364 --> 00:51:41,999
HEALTH AND PROVIDE A READY TEST

1499
00:51:41,999 --> 00:51:43,668
BED FOR NEW TECHNOLOGIES AND

1500
00:51:43,668 --> 00:51:45,436
GNAW APPROACHES, NEW THINKING

1501
00:51:45,436 --> 00:51:47,472
ABOUT HOW WE USE PATHOGENOMICS,

1502
00:51:47,472 --> 00:51:51,442
WE TRY TO INSURE THAT WE HAVE A

1503
00:51:51,442 --> 00:51:52,376
GOOD ONGOING COLLABORATION

1504
00:51:52,376 --> 00:51:54,345
BETWEEN THE ACADEMICS AND THE

1505
00:51:54,345 --> 00:51:55,713
PUBLIC HEALTH PEOPLE THAT ARE

1506
00:51:55,713 --> 00:51:59,350
ACTUALLY IMP LEMMING THESE TYPE

1507
00:51:59,350 --> 00:52:01,185
OF SOLUTIONS, AND WE HAVE AN

1508
00:52:01,185 --> 00:52:02,120
ONGOING OPPORTUNITY FOR

1509
00:52:02,120 --> 00:52:03,755
WORKFORCE DEVELOPMENT AND

1510
00:52:03,755 --> 00:52:04,255
RECRUITMENT.

1511
00:52:04,255 --> 00:52:06,491
YOU KNOW BY AGAIN INCREASING

1512
00:52:06,491 --> 00:52:08,126
THAT REACTION SURFACE BETWEEN

1513
00:52:08,126 --> 00:52:09,427
ACADEME IMRA AND PUBLIC HEALTH

1514
00:52:09,427 --> 00:52:12,296
THIS, GIVES US A WARM BASE TO

1515
00:52:12,296 --> 00:52:14,799
BRING IN JUNIOR FACULTY, NEW

1516
00:52:14,799 --> 00:52:16,134
GRADUATES INTO PUBLIC HEALTH

1517
00:52:16,134 --> 00:52:17,301
CAREER ANDS EXPOSE THEM TO THE

1518
00:52:17,301 --> 00:52:19,203
KINDS OF PROBLEM ANDS HOPEFULLY

1519
00:52:19,203 --> 00:52:21,539
CONVINCE THEM TO STAY.

1520
00:52:21,539 --> 00:52:24,075
THIS ALSO GIVES US AN IMPORTANT

1521
00:52:24,075 --> 00:52:25,143
TOOL FOR RESILIENCE, THE FIRST

1522
00:52:25,143 --> 00:52:27,712
YEAR OR 2 YEARS OF THE PANDEMIC

1523
00:52:27,712 --> 00:52:29,347
AND EVEN TODAY, YOU KNOW

1524
00:52:29,347 --> 00:52:30,982
ACADEMIC AND CLINICAL LABS

1525
00:52:30,982 --> 00:52:32,717
PLAYED AN OUTSIZED ROLE IN THE

1526
00:52:32,717 --> 00:52:33,785
PUBLIC HEALTH RESPONSE, AND THIS

1527
00:52:33,785 --> 00:52:35,987
GIVES US SOME STRUCTURE, SOME

1528
00:52:35,987 --> 00:52:37,288
ABILITY TO ACTUALLY SURGE THAT

1529
00:52:37,288 --> 00:52:39,357
KIND OF CAPABILITY TO HAVE THAT

1530
00:52:39,357 --> 00:52:40,091
ACADEMIC PARTNERSHIP ALREADY IN

1531
00:52:40,091 --> 00:52:41,826
PLACE ISSUES THE AGREEMENTS

1532
00:52:41,826 --> 00:52:43,427
THAT'S ALREADY THERE, THE DATA

1533
00:52:43,427 --> 00:52:45,396
USE AND TRANSFER AGREEMENTS IN

1534
00:52:45,396 --> 00:52:47,498
PLACE, AND HAVE THAT FAMILIARITY

1535
00:52:47,498 --> 00:52:49,400
IN THE LOCAL NETWORKS READY TO

1536
00:52:49,400 --> 00:52:57,909
FIRE, SHOULD WE NEED THEM.

1537
00:52:57,909 --> 00:52:59,343
THE LAST THING I WANT TO

1538
00:52:59,343 --> 00:53:01,045
MENTION, IS THE AMD PLATFORM, SO

1539
00:53:01,045 --> 00:53:01,979
1 THINK THIS WE HAVE LEARNED IS

1540
00:53:01,979 --> 00:53:05,216
THE NEED FOR A CONSISTENT

1541
00:53:05,216 --> 00:53:08,386
ENVIRONMENT FOR BY O INFORMATIC

1542
00:53:08,386 --> 00:53:08,853
TOOLS.

1543
00:53:08,853 --> 00:53:11,022
ONE THE CHALLENGES WE FACE IN

1544
00:53:11,022 --> 00:53:12,957
PUBLIC HEALTH IS EACHITATE AND

1545
00:53:12,957 --> 00:53:14,225
PUBLIC LOCAL HEALTH DEPARTMENT,

1546
00:53:14,225 --> 00:53:17,161
ALL OF OUR GLOBAL PARTNER VS

1547
00:53:17,161 --> 00:53:17,995
DIFFERENT ACCESS TO

1548
00:53:17,995 --> 00:53:19,997
BIOINFORMATICS TO CLOUD

1549
00:53:19,997 --> 00:53:24,569
RESOURCES TO I.T., I.T.

1550
00:53:24,569 --> 00:53:26,137
EXPERTISE, MANY STATES AND STATE

1551
00:53:26,137 --> 00:53:27,872
LOCAL GOVERNMENTS HAVE PREFERRED

1552
00:53:27,872 --> 00:53:29,006
CLOUD VENDORS THAT DON'T

1553
00:53:29,006 --> 00:53:30,441
NECESSARILY ALIGN WITH THOSE IN

1554
00:53:30,441 --> 00:53:32,376
NEIGHBORING STATES OR YOU KNOW

1555
00:53:32,376 --> 00:53:35,713
THE REGION OR FEDERAL PARTNERS.

1556
00:53:35,713 --> 00:53:39,684
SO BY PROVIDING A CONSISTENT BY

1557
00:53:39,684 --> 00:53:41,319
O INFORMA, A SYSTEM WHERE THESE

1558
00:53:41,319 --> 00:53:43,754
TOOLS CAN RUN IN A CONSISTENT

1559
00:53:43,754 --> 00:53:44,722
WAY, IT ALLOWS US TO HAVE AN

1560
00:53:44,722 --> 00:53:47,191
ENVIRONMENT WHERE A LOT OF THE

1561
00:53:47,191 --> 00:53:49,460
CDC SUPPORTED ANALYSIS PLATFORM

1562
00:53:49,460 --> 00:53:52,363
WORK FLOWS CAN RUN CONSISTENTLY,

1563
00:53:52,363 --> 00:53:54,198
CAN PROVIDE ROUTINE ACCESS TO

1564
00:53:54,198 --> 00:53:56,367
THAT AND IDEALLY, PROVIDE AN

1565
00:53:56,367 --> 00:53:57,001
INTEROPERABLE ENVIRONMENT THAT

1566
00:53:57,001 --> 00:53:59,136
CAN WORK WITH MULTIPLE DEFINITE

1567
00:53:59,136 --> 00:53:59,737
DATA SYSTEMS.

1568
00:53:59,737 --> 00:54:02,840
THIS IS MOVING ALONG PRETTY

1569
00:54:02,840 --> 00:54:03,674
STEADILY, WE'VE GOT--PROBABLY

1570
00:54:03,674 --> 00:54:05,543
GET AN UPDATE ON THIS LATER.

1571
00:54:05,543 --> 00:54:07,278
I DON'T WANT TO DWELL WITH TOO

1572
00:54:07,278 --> 00:54:08,880
MUCH ON THIS BUT WE ARE REALLY

1573
00:54:08,880 --> 00:54:09,680
EXCITED ABOUT THIS.

1574
00:54:09,680 --> 00:54:10,681
ON THE BACK END, WE'RE ALSO

1575
00:54:10,681 --> 00:54:12,450
DOING A LOT OF WORK TO TRY TO

1576
00:54:12,450 --> 00:54:15,152
STANDARDIZE A LOT OF TOOLING AND

1577
00:54:15,152 --> 00:54:16,787
BIOINFORMATIC PIPELINES AND ARE

1578
00:54:16,787 --> 00:54:18,189
USED RETEENLY BECAUSE IDEALLY WE

1579
00:54:18,189 --> 00:54:20,958
WANT THEM TO BE CONTAINERIZED

1580
00:54:20,958 --> 00:54:22,727
PORTABLE SCALABLE, IN WAYS THAT

1581
00:54:22,727 --> 00:54:26,564
CAN BE BROUGHT INTO OTHER

1582
00:54:26,564 --> 00:54:29,066
ENVIRONMENTS AND DEPLOYED

1583
00:54:29,066 --> 00:54:30,134
PARTNERS AS NEEDED.

1584
00:54:30,134 --> 00:54:32,770
WE PUT VIRTUALLY ALL OF THE NEW

1585
00:54:32,770 --> 00:54:36,207
PIPELINES OUT ON GITHUB, EITHER

1586
00:54:36,207 --> 00:54:38,409
THE CDC GITHUB OR THE UTAH

1587
00:54:38,409 --> 00:54:41,178
PUBLIC HEALTH LABS, FANTASTIC

1588
00:54:41,178 --> 00:54:42,647
SECRET TOOL KIT DEVELOPED BY

1589
00:54:42,647 --> 00:54:43,047
AARON YOUNG.

1590
00:54:43,047 --> 00:54:44,849
A LOT OF THESE ARE DEVELOPED IN

1591
00:54:44,849 --> 00:54:46,550
CONTAINERIZED WAY ANDS CAN BE

1592
00:54:46,550 --> 00:54:47,151
RAPID LOAMACYY DEPLOYED.

1593
00:54:47,151 --> 00:54:51,956
WE JUST HAD A PRESENTATION ON

1594
00:54:51,956 --> 00:54:53,024
YESTERDAY'S SPHERES CALL FOR

1595
00:54:53,024 --> 00:54:57,762
STATUS, AND THIS IS OUR OPEN

1596
00:54:57,762 --> 00:54:58,496
T-REGGAGE AND DATABASE

1597
00:54:58,496 --> 00:54:58,796
SUBMISSION.

1598
00:54:58,796 --> 00:54:59,797
THIS A LOT OF THIS IS ON THE

1599
00:54:59,797 --> 00:55:01,632
TOOLING OVER THE COURSE OF THE

1600
00:55:01,632 --> 00:55:03,834
PANDEMIC TO TAKE THOSE MASSIVE

1601
00:55:03,834 --> 00:55:05,236
AMOUNTS OF COMMERCIAL SEQUENCE

1602
00:55:05,236 --> 00:55:09,473
DATA AND PUSH THAT INTO GISAID

1603
00:55:09,473 --> 00:55:11,442
AND GENBANK TO STANDARDIZE

1604
00:55:11,442 --> 00:55:12,944
METADAILY BASIS THEA TO RUN

1605
00:55:12,944 --> 00:55:14,111
QUALITY CONTROL CHECKS BUT A LOT

1606
00:55:14,111 --> 00:55:16,247
OF THAT IS MODULAR AND A LOT OF

1607
00:55:16,247 --> 00:55:18,582
IT IS DESIGNED FOR VIRAL AND

1608
00:55:18,582 --> 00:55:19,650
VECTERAL PATHOGENS AND SO BY

1609
00:55:19,650 --> 00:55:21,319
PUTTING THESE TOOLS OUT THERE,

1610
00:55:21,319 --> 00:55:22,987
MAKING THEM MODULAR, THEY CAN BE

1611
00:55:22,987 --> 00:55:24,088
USED AND REUSED, WE'RE REALLY

1612
00:55:24,088 --> 00:55:26,891
EXCITED ABOUT THE FUTURE OF

1613
00:55:26,891 --> 00:55:27,992
AVAILABILITY OF SOME OF THESE

1614
00:55:27,992 --> 00:55:28,225
TOOLS.

1615
00:55:28,225 --> 00:55:29,961
AND THEN THE LAST, THE VERY LAST

1616
00:55:29,961 --> 00:55:35,633
THING I WILL TALK ABOUT IS THE

1617
00:55:35,633 --> 00:55:36,901
QUALITY INITTIAIVE ITS WHICH

1618
00:55:36,901 --> 00:55:38,336
LAUNCHED IN 2019, WE'VE SINCE

1619
00:55:38,336 --> 00:55:41,839
REVAMPED IT BUT I THINK IT WILL

1620
00:55:41,839 --> 00:55:44,075
CONTINUE TO PLAY AN OUTSIDE ROLE

1621
00:55:44,075 --> 00:55:45,876
ESPECIALLY WITH THE REGULATORY

1622
00:55:45,876 --> 00:55:46,744
SCRUTINY THAT'S COMING DOWN THE

1623
00:55:46,744 --> 00:55:48,379
LINE EMPLOY TO DATE IT'S

1624
00:55:48,379 --> 00:55:49,981
RELEASED OVER A HUNDRED

1625
00:55:49,981 --> 00:55:51,482
DIFFERENT TOOLS, CHECK LIST AND

1626
00:55:51,482 --> 00:55:55,953
TEMPLATES IF YOU JUST GOOGLE NG

1627
00:55:55,953 --> 00:55:56,787
S QUALITY INITIATIVE, IT WILL

1628
00:55:56,787 --> 00:55:58,990
BRING YOU TO THIS PAGE AND

1629
00:55:58,990 --> 00:56:00,491
THEY'RE ALL DOWNLOADABLE AND

1630
00:56:00,491 --> 00:56:00,791
SEARCHABLE.

1631
00:56:00,791 --> 00:56:01,993
SO I WILL WRAP IT THERE.

1632
00:56:01,993 --> 00:56:03,995
I HAVE A FEW CRITICAL LESSONS

1633
00:56:03,995 --> 00:56:05,596
AND FUTURE DIRECTIONS BUT I

1634
00:56:05,596 --> 00:56:07,565
REALLY WOULD WELCOME SOME

1635
00:56:07,565 --> 00:56:09,533
QUESTIONS OR DISCUSSION IN THE

1636
00:56:09,533 --> 00:56:10,935
FEW MAINUTES THAT REMAIN.

1637
00:56:10,935 --> 00:56:17,441
APOLOGIZE FOR GOING A BIT OVER,

1638
00:56:17,441 --> 00:56:17,808
KYLE.

1639
00:56:17,808 --> 00:56:19,510
>> NO, THIS HAS BEEN
GREAT.

1640
00:56:19,510 --> 00:56:20,611
SO, SO, INTERESTING.

1641
00:56:20,611 --> 00:56:22,146
I SEE A BUNCH OF QUESTIONS IN

1642
00:56:22,146 --> 00:56:24,015
THE BACKGROUND AND IF FOLKS HAVE

1643
00:56:24,015 --> 00:56:24,882
OTHERS, FEEL FREE TO SUBMIT

1644
00:56:24,882 --> 00:56:25,082
THEM.

1645
00:56:25,082 --> 00:56:30,654
LET ME SEE HERE. 

1646
00:56:30,654 --> 00:56:34,191
I'M CURIOUS DUNCAN WHAT--I'M

1647
00:56:34,191 --> 00:56:35,860
SURE STANDING UP THAT FEDERAL

1648
00:56:35,860 --> 00:56:37,561
AND DPROABAL NETWORK, THERE WERE

1649
00:56:37,561 --> 00:56:39,563
A LOT OF HURDLES THAT YOU

1650
00:56:39,563 --> 00:56:41,198
ENCOUNTERED THAT WERE FAMILIAR

1651
00:56:41,198 --> 00:56:43,701
TO YOU, BUT MAYBE JUST AT A MUCH

1652
00:56:43,701 --> 00:56:45,736
LARGER KALE BECAUSE OF THE

1653
00:56:45,736 --> 00:56:47,238
UNIQUE CHALLENGES OF COVID.

1654
00:56:47,238 --> 00:56:48,639
I'M CURIOUS WHAT YOU WOULD

1655
00:56:48,639 --> 00:56:50,775
CHARACTERIZE AS THE BIGGEST

1656
00:56:50,775 --> 00:56:53,144
SURPRISE, MAYBE SOMETHING YOU

1657
00:56:53,144 --> 00:56:55,079
DIDN'T EXPECT FROM STANDING UP

1658
00:56:55,079 --> 00:56:58,282
THAT SORT OF INITIATIVE.

1659
00:56:58,282 --> 00:56:59,483
I THINK THE BIGGEST SURPRISE WAS

1660
00:56:59,483 --> 00:57:03,054
JUST A LEVEL OF ENTHUSIASM THAT

1661
00:57:03,054 --> 00:57:04,388
I SAW THROUGHOUT.

1662
00:57:04,388 --> 00:57:07,725
I THINK IT WAS--IT IS, WAS, IS A

1663
00:57:07,725 --> 00:57:10,127
UNIQUE SET OF CIRCUMSTANCES.

1664
00:57:10,127 --> 00:57:11,929
I THINK THERE WAS, YOU KNOW YOU

1665
00:57:11,929 --> 00:57:14,598
HAD MANY ACADEMIC AND CLINICAL

1666
00:57:14,598 --> 00:57:15,533
LABORATORIES WHOSE NORMAL

1667
00:57:15,533 --> 00:57:18,502
ROUTINE WORK HAD BEEN DISRUPTED,

1668
00:57:18,502 --> 00:57:19,336
JUST THE WILLINGNESS AND

1669
00:57:19,336 --> 00:57:22,540
ACTIVITY FROM A LOT OF THESE

1670
00:57:22,540 --> 00:57:23,441
DIFFERENT PARTNERS, BEFORE THAT

1671
00:57:23,441 --> 00:57:25,643
MAY HAVE HAD LIMITED EXPERIENCE

1672
00:57:25,643 --> 00:57:27,044
WITH PUBLIC HEALTH, SUDDENLY

1673
00:57:27,044 --> 00:57:28,879
ENTERING INTO THAT REALM, I

1674
00:57:28,879 --> 00:57:31,382
THINK THE OTHER PIECE WAS JUST

1675
00:57:31,382 --> 00:57:33,317
THE WELCOMENESS FROM THE PUBLIC

1676
00:57:33,317 --> 00:57:35,853
HEALTH COMMUNITY AT ALL LEVELS.

1677
00:57:35,853 --> 00:57:37,721
I THINK YOU KNOW I THINK THERE'S

1678
00:57:37,721 --> 00:57:38,856
A RECOGNITION THAT EVERYONE IS

1679
00:57:38,856 --> 00:57:39,690
ON THE SAME TEAM.

1680
00:57:39,690 --> 00:57:41,859
I THINK THERE WAS A WILLINGNESS

1681
00:57:41,859 --> 00:57:43,561
TO FIGURE OUT HOW TO NAVIGATE

1682
00:57:43,561 --> 00:57:45,663
THE NECESSARY PROCESS TO MAKE

1683
00:57:45,663 --> 00:57:46,030
THINGS WORK.

1684
00:57:46,030 --> 00:57:49,834
AND YOU KNOW IF MANY WAYS, IT

1685
00:57:49,834 --> 00:57:52,837
REALLY BECAME A REALLY EFFECTIVE

1686
00:57:52,837 --> 00:57:53,737
PARTNERSHIP AND I--MAYBE I

1687
00:57:53,737 --> 00:57:55,172
SHOULDN'T HAVE BEEN SURPRISED BY

1688
00:57:55,172 --> 00:57:57,241
THAT BUT I WAS SURPRISED

1689
00:57:57,241 --> 00:57:59,610
SOMETIMES BY THE WILLINGNESS.

1690
00:57:59,610 --> 00:58:00,945
>> I'M SURE A VERY WELCOME

1691
00:58:00,945 --> 00:58:04,748
SILVER LINING TO ALL OF THOSE

1692
00:58:04,748 --> 00:58:05,216
EFFORTS.

1693
00:58:05,216 --> 00:58:06,383
>> LET'S SEE LOOKING AT
THE

1694
00:58:06,383 --> 00:58:08,953
QUESTIONS HERE, ARE THERE

1695
00:58:08,953 --> 00:58:09,653
CHALLENGES TO GETTING

1696
00:58:09,653 --> 00:58:10,721
BIOINFORMAT 8 HOURSS INVOFFED?

1697
00:58:10,721 --> 00:58:12,823
THAT CAN BE A RATE LIMITING STEP

1698
00:58:12,823 --> 00:58:15,726
THAT ARE KEY TO THESE SORTS OF

1699
00:58:15,726 --> 00:58:15,960
EFFORTS?

1700
00:58:15,960 --> 00:58:19,630
>> SO THE TRUTH IS WE CAN
NEVER

1701
00:58:19,630 --> 00:58:20,598
HAVE ENOUGH BIOINFORMATICIANS,

1702
00:58:20,598 --> 00:58:22,299
BUT YOU KNOW DURING THE

1703
00:58:22,299 --> 00:58:23,567
PANDEMIC, THIS IS ESPECIALLY

1704
00:58:23,567 --> 00:58:26,570
TRUE BECAUSE WE, YOU KNOW WE HAD

1705
00:58:26,570 --> 00:58:30,608
SORT OF A CADRE OF

1706
00:58:30,608 --> 00:58:31,909
BIOINFORMATICIANS AT CDC AND

1707
00:58:31,909 --> 00:58:33,177
LOCAL HEALTH DEPARTMENTS,

1708
00:58:33,177 --> 00:58:35,479
WORKING INSANE HOURS TRYING TO

1709
00:58:35,479 --> 00:58:37,214
ANALYZE, INTERPRET AND PROVIDE

1710
00:58:37,214 --> 00:58:38,949
STAT REPORTS ON VARIANTS FOR A

1711
00:58:38,949 --> 00:58:40,384
VARIETY OF DIFFERENT AUDIENCES

1712
00:58:40,384 --> 00:58:42,419
AND CONSUMERS FROM YOU KNOW THE

1713
00:58:42,419 --> 00:58:44,722
WHITE HOUSE DOWN TO THE LOCAL

1714
00:58:44,722 --> 00:58:46,223
MAYOR'S OFFICE AND YOU KNOW IN

1715
00:58:46,223 --> 00:58:48,959
MANY CASES YOU JUST SAW PEOPLE

1716
00:58:48,959 --> 00:58:51,228
BURNING OUT AND NOT HAVING

1717
00:58:51,228 --> 00:58:54,431
ENOUGH BAND WIDTH TO SUPPORT ALL

1718
00:58:54,431 --> 00:58:55,499
THE NEEDS.

1719
00:58:55,499 --> 00:58:57,201
THAT'S A CHALLENGE WHEN YOU HAVE

1720
00:58:57,201 --> 00:59:01,305
A HIGHLY, HIGHLY SKILLED SKILL

1721
00:59:01,305 --> 00:59:02,940
SET AND HIGH DEMANDS ON IT.

1722
00:59:02,940 --> 00:59:04,775
THERE WERE SOME REALLY

1723
00:59:04,775 --> 00:59:05,442
INTERESTING OPPORTUNITIES

1724
00:59:05,442 --> 00:59:06,310
THROUGHOUT THAT, YOU KNOW 1 OF

1725
00:59:06,310 --> 00:59:09,613
THE THINGS THAT WE DID WITH ABHL

1726
00:59:09,613 --> 00:59:11,916
WAS TO CREATE THESE GENOMIC

1727
00:59:11,916 --> 00:59:13,918
INTERNSHIPS THAT WERE VIRTUAL,

1728
00:59:13,918 --> 00:59:17,221
THAT BASICALLY PAIRED, THEY WERE

1729
00:59:17,221 --> 00:59:19,056
PART-TIME WORK, THEY ALLOWED AN

1730
00:59:19,056 --> 00:59:20,090
EXISTING GRADUATE STUDENT OR

1731
00:59:20,090 --> 00:59:21,592
SOMEBODY SHANKAR HAS THE

1732
00:59:21,592 --> 00:59:23,093
NECESSARY BACKGROUND AND

1733
00:59:23,093 --> 00:59:25,996
QUALIFICATIONS TO BE PAIRED WITH

1734
00:59:25,996 --> 00:59:27,731
A STATE OR LOCAL HELT

1735
00:59:27,731 --> 00:59:30,634
ENVIRONMENT TO HELP OUT WITH THE

1736
00:59:30,634 --> 00:59:32,736
BIOINFORMATIC DATA ARGSINAL SIS,

1737
00:59:32,736 --> 00:59:34,905
DATA, QC, SUBMISSION ON THE BACK

1738
00:59:34,905 --> 00:59:37,107
END AND YOU KNOW, FOR US IT'S

1739
00:59:37,107 --> 00:59:38,209
SORT OF 2 THINGS, YOU KNOW IT

1740
00:59:38,209 --> 00:59:39,843
HELPED WITH THOSE INITIAL

1741
00:59:39,843 --> 00:59:41,345
WORKFORCE CHALLENGES AND MAKING

1742
00:59:41,345 --> 00:59:42,880
SURE WE HAD SKILLED HANDS

1743
00:59:42,880 --> 00:59:44,548
THROUGHOUT THE COUNTRY THAT

1744
00:59:44,548 --> 00:59:46,050
COULD BE DRAWN ON BUT IT ALL

1745
00:59:46,050 --> 00:59:47,184
ACTED AS A LITTLE BIT OF A

1746
00:59:47,184 --> 00:59:48,586
FEEDER FOR SOME OF OUR

1747
00:59:48,586 --> 00:59:51,288
FELLOWSHIP PROGRAMS WHICH I'M

1748
00:59:51,288 --> 00:59:52,256
REALLY EXCITED ABOUT.

1749
00:59:52,256 --> 00:59:52,790
>> YEAH, THAT'S GREAT.

1750
00:59:52,790 --> 00:59:58,495
ON THAT UPON --TOPIC, HAVE YOU

1751
00:59:58,495 --> 01:00:00,097
THOUGHT ABOUT INTEGRATE

1752
01:00:00,097 --> 01:00:01,932
THANKSGIVING INFO INTO COLLEGE

1753
01:00:01,932 --> 01:00:03,968
CURRICULUMS IN TERMS OF COLLEGE

1754
01:00:03,968 --> 01:00:04,635
RECRUITEES OR TRAINEES.

1755
01:00:04,635 --> 01:00:06,937
YOU TALK ABOUT THE NICE PROGRAMS

1756
01:00:06,937 --> 01:00:09,807
YOU HELP SET UP TO DRAFT THE

1757
01:00:09,807 --> 01:00:11,775
NEXT GENERATION OF

1758
01:00:11,775 --> 01:00:12,142
EPIDEMIOLOGISTS?

1759
01:00:12,142 --> 01:00:12,843
>> YEAH, 1 OF THE THINGS
THAT

1760
01:00:12,843 --> 01:00:15,746
WE'RE TRYING TO DO IS INCREASE

1761
01:00:15,746 --> 01:00:16,814
OUR OUTREACH.

1762
01:00:16,814 --> 01:00:18,716
IF I LOOK OVER THE APPLICATIONS

1763
01:00:18,716 --> 01:00:20,784
TO OUR FELLOWSHIP PROGRAM, WHAT

1764
01:00:20,784 --> 01:00:25,356
I USUALLY FIND IS SOME OF THE

1765
01:00:25,356 --> 01:00:26,023
MOST EFFECTIVE--EFFECTIVE ADVOCA

1766
01:00:26,023 --> 01:00:28,659
THES THAT WE HAD ARE USUALLY

1767
01:00:28,659 --> 01:00:31,695
WHERE WE SEE HEATED APPLICATIONS

1768
01:00:31,695 --> 01:00:32,763
FROM SINGLE SCHOOLS, IT'S

1769
01:00:32,763 --> 01:00:34,565
USUALLY IN THE CASE WHERE WE

1770
01:00:34,565 --> 01:00:36,200
HAVE A VERY STRONG ADVOCATE,

1771
01:00:36,200 --> 01:00:38,335
THAT GOES ON LECTURES THERE OR

1772
01:00:38,335 --> 01:00:39,737
ADVERTISES THE PROGRAM OR

1773
01:00:39,737 --> 01:00:40,904
PROMOTES IT WITH STUDENTS AND

1774
01:00:40,904 --> 01:00:42,740
STAFF, WE'RE STARTING TO BUILD

1775
01:00:42,740 --> 01:00:45,042
OUT AN ALUMNI NETWORK, WE HAVE

1776
01:00:45,042 --> 01:00:46,110
NEW PARTNERSHIPS WITH FERGUSON,

1777
01:00:46,110 --> 01:00:48,012
WE CONTINUE TO HAVE PARTNERSHIPS

1778
01:00:48,012 --> 01:00:49,346
WITH EXISTING FELLOWSHIPS AND WE

1779
01:00:49,346 --> 01:00:51,515
LIKE THE LABORATORY OF

1780
01:00:51,515 --> 01:00:55,286
LEADERSHIP SERVICE AT CNC, LIKE

1781
01:00:55,286 --> 01:00:57,187
THE EIS PROGRAM, CDC, THE

1782
01:00:57,187 --> 01:00:58,188
CONTINUING TO BUILD THAT, BUT

1783
01:00:58,188 --> 01:01:00,090
YOU KNOW I THINK 1 OF THE

1784
01:01:00,090 --> 01:01:01,025
FUNDAMENTAL THINGS IS, YOU KNOW

1785
01:01:01,025 --> 01:01:02,559
WE NEED TO PUT THESE

1786
01:01:02,559 --> 01:01:05,229
OPPORTUNITIES IN FRONT OF MORE

1787
01:01:05,229 --> 01:01:08,432
PEOPLE AND NOT ONLY SORT OF THE

1788
01:01:08,432 --> 01:01:09,600
REGULAR SCHOOL ANDS PROGRAMS

1789
01:01:09,600 --> 01:01:11,201
THAT WE INTERACT WITH REGULARLY,

1790
01:01:11,201 --> 01:01:14,972
BUT A LOT OF THE PROGRAMS THAT

1791
01:01:14,972 --> 01:01:16,006
DON'T NECESSARILY GET THAT

1792
01:01:16,006 --> 01:01:17,808
OPPORTUNITY SO WE'RE DEFINITELY

1793
01:01:17,808 --> 01:01:18,609
LOOKING AT THAT.

1794
01:01:18,609 --> 01:01:19,576
>> GREAT, AND WITH THAT, I
SEE

1795
01:01:19,576 --> 01:01:21,745
WE ARE AT THE TOP OF THE HOUR.

1796
01:01:21,745 --> 01:01:24,481
SO I WILL THANK YOU AGAIN DUNCAN

1797
01:01:24,481 --> 01:01:25,716
FOR YOUR TIME AND SHARING THIS

1798
01:01:25,716 --> 01:01:27,885
REALLY CRUCIATE LIGAMENTNIQUE

1799
01:01:27,885 --> 01:01:28,852
AND INSPIRING STORY AND THANKS

1800
01:01:28,852 --> 01:01:39,163
ALL FOR TUNING IN.