>>WELCOME, EVERYBODY.
I'M SUSAN WEIS AND I'M HERE
TODAY SERVING AS THE DESIGNATED
OFFICIAL FOR THE MULTI
COUNCIL WORKING GROUP.
I WANT TO WELCOME EVERYBODY TO
THE 23rd MEETING OF THE NIH
BRAIN INITIATIVE MCWG AND AS
ALWAYS, THANK YOU FOR YOUR TIME
AND YOUR CONTRIBUTIONS TO THE
EFFORT, WHICH ARE REALLY VERY
MUCH APPRECIATED.
THE MEETING TODAY WILL BEGIN
WITH THE OPEN SESSION WHICH IS
BEING VIDEO CAST AND RECORDED
AND WILL BE SUBSEQUENTLY
ARCHIVED ON THE WEB SITES.
WE'LL BEGIN WITH AN UPDATE WITH
AN UPDATE FROM OUR DIRECTOR
Dr. JOHN NGAI AND THE ANNUAL
BRAIN MEETING.
Dr. HANK GREELY IS GOING TO
SUMMARIZE SOME OF THE VERY
INTERESTING DISCUSSIONS FROM
YESTERDAY'S NEUROETHICS WORKING
GROUP MEETING AND WE WILL TAKE A
BREAK BEFORE THE OPEN SESSION.
UNFORTUNATELY, WE HAVE TO
POSTPONE Dr. MOORE'S
PRESENTATION SINCE HE WAS NOT
FEELING WELL TODAY.
WE WOULD LIKE TO THANK Dr.
KATRINA GWEN HARDY FOR SERVING
ON THE MCWG AND DA MACK MILLEN E
ARE SAYING GOOD-BYE WITH OUR
FINAL MEETING AND WE WILL MISS
THEM.
THEY'VE BEEN PART OF THE MCWG
SINCE IT FIRST BEGAN IN AUGUST
OF 2014 AND JOHN WILL TALK A
LITTLE BIT MORE ABOUT THIS.
I WILL BE VERY BRIEF IN MY
OPENING REMARKS, AS MOST OF YOU
KNOW, THE MCWG IS NOT A FORMAL
ADVISORY GROUP THAT FALLS UNDER
THE FEDERAL ADVISORY COMMITTEE
ACT BUT IT WAS ESTABLISHED
BECAUSE OF THE RECOGNIZED NEED
FOR DIVERSE EXPERTISE IN A
VARIOUS DISCIPLINES IN ORDER TO
PROPERLY ASSESS THE RESEARCH
BEING SUPPORTED THROUGH BRAIN.
SOME OF THE MEMBERS ARE FROM THE
10 INSTITUTES CENTER ADVISORY
COUNCILS OF THE 10 PARTICIPATING
INSTITUTES AND CENTERS WITH
ADDITIONAL AT-LARGE MEMBERS
APPOINTED TO SUPPLEMENT THE
WORKING GROUPS, EXPERTISE AND
OTHERS GROUPS FOUR OF OUR
PARTNERS IN THE BRAIN
INITIATIVE.
WE DEPEND ON THE MCWG FOR ON
GOING OVERSIGHT OF SCIENTIFIC
VISION OF THE BRAIN, FOR
FEEDBACK ON CONCEPT CLEARANCES
THAT ARE EXPECTED TO DEVELOP
INTO FUNDING OPPORTUNITIES, AND
IN THE CLOSED SESSION FOR IN PUT
ON THE FUNDING PLANS.
WHEN WE GO TO THE CLOSED
SESSION, I WILL GO OVER SOME OF
OUR OPERATING PROCEDURES AND
THAT WILL BEGIN AFTER 30-MINUTE
BREAK WHICH WE EXPECT TO BE IN
AROUND 1:30 TODAY BUT NOTE
THERE'S A DIFFERENT LINK FOR THE
CLOSED SESSION AND THAT WILL BE
FOR MEMBERS OF THE COUNCIL AND
GOVERNMENT FTEs, EMPLOYEES
ONLY.
AGAIN, THE OPEN SESSION IS BEING
VIDEO CAST AND RECORDED.
A FEW HOUSEKEEPING ITEMS, DURING
THE SLIDE PRESENTATIONS, PLEASE
MAKE SURE TO MUTE YOUR LINE AND
DURING DISCUSSIONS, PLEASE MAKE
SURE THAT YOUR VIDEO IS ON AND
WE ASK YOU TO USE THE
RAISED-HAND OPTION IF YOU HAVE
QUESTIONS SO WE CAN CALL ON YOU
TO UNMUTE YOURSELF.
THE CHAT IS NOT GOING TO BE
VISIBLE TO THE PEOPLE ON THE
VIDEO CAST WHICH IS WHY WE
PREFER YOU USE THIS STRAT GOOD
EVENING FOR ASKING QUESTIONS.
FINALLY, THIS IS A LOT OF WORK
IN PREPARATION FOR THIS MEETING
AND WE HAVE QUITE EXCELLENT
PEOPLE WORKING ON IT WHO I WILL
THANK ONCE AGAIN, KRISTEN
DUPRES, NINA TSU AND MICHELLE
PEARSON, THEY'RE OUTSTANDING
COLLEAGUES AND I KNOW YOU KNOW
THIS SINCE YOU'VE BEEN WORKING
WITH THEM.
IF ANYONE HAS TECHNICAL
PROBLEMS, E-MAIL KRISTEN AND SHE
AND HER TEAM WILL SORT THINGS
OUT FOR YOU.
WITH THAT, I'LL TURN IT OVER TO
JOHN.
>> John: THANK YOU, SUSAN.
AND THANK YOU ALL FOR BEING HERE
AND MOST OF ALL, THANK YOU TO
THE GREAT STAFF WHO MAKES
EVERYTHING POSSIBLE.
I JUST HAVE A FEW REMARKS HERE
TO SHARE WITH YOU AND THEN
FOLLOWING THAT, Dr. SAM WHITE
WILL GIVE AN UPDATE ON OUR
REVIEW OF THE RECENT BRAIN
INITIATIVE MEETING THAT HAPPENED
IN JUNE.
SO LET'S SEE.
CAN YOU SEE THE RIGHT SET OF
SLIDES HERE?
>> YES.
>> John: OK.
SORRY I HAVE SCREEN ALL OVER THE
PLACE AND MY CONTROLS ARE NOT
WHERE I CAN SEE THEM.
GIVE ME A SECOND.
SORRY.
SO, AGAIN WELCOME AND I
APPRECIATE YOUR TIME AND EFFORT
FOR BEING HERE.
UNFORTUNATELY, I NEED TO START
OFF ON A QUITE SAD NOTE.
THE NIH FAMILY LOST ONE OF OUR
CHERISHED FAMILY MEMBERS Dr.
MIKE STEINMETZ WHO PASSED AWAY
END OF JULY BECAUSE OF A BOATING
ACCIDENT.
MANY OF YOU HAVE KNOWN MIKE FOR
DECADES.
I ONLY HAD THE PLEASURE OF
WORKING WITH HIM FOR A FEW
YEARS.
HE JOINED NATIONAL EYE INSTITUTE
IN 2007 WHERE HE WAS THE
DIVISION OF THE -- DIRECTOR OF
EXTRAMURAL SCIENCE PROGRAMS.
HE WAS KNOWN ACROSS NIH FOR HIS
MANY, MANY CONTRIBUTIONS.
HE WAS AN EARLY VOICE IN THE
BRAIN INITIATIVE AS WELL AS THE
NIH BLUE PRINT AND HELPED SHAPE
THESE INITIATIVES, WITH THE
VISION THAT NAI COULD REALLY
CONTRIBUTE TO NEUROSCIENCE
RESEARCH AND I THINK WE'VE SEEN
THAT PLAY OUT OVER THE LAST MANY
YEARS.
HE WAS KNOWN, ADMIRED AND LOVED
BY MANY AS A WONDERFUL COLLEAGUE
AND MENTOR AND FOR HIS WISDOM,
HIS GOOD HUMOR AND HIS GRACE.
I THINK IT'S FAIR TO SAY MIKE
WAS AN INSTITUTION AND WE'LL ALL
MISS HIM, VERY, VERY DEEPLY.
YOU CAN READ HIS OBITUARY AT THE
LINK THAT -- WE CAN PROVIDE A
LINKLATER IF YOU WISH.
SO, VERY SAD NEWS BUT WE STRIVE
TO LIVE UP TO THE STANDARDS THAT
MIKE SET OUT FOR ALL OF US AND
ALL THE WORK THAT WE DO.
>>> OK.
WE'RE SAYING FAREWELL FOR NOW,
FOR TWO LONG-SERVING MCWG
MEMBERS.
Dr. FRANCIS JENSEN AND HANK
GREELY.
THEY'VE BEEN ON MCWG SINCE THE
BEGINNING, 2014.
TECHNICALLY THIS MIGHT BE
CONSTRUED AS TWO FOUR-YEAR TERMS
BUT BACK WHEN THEY WERE COMMIT
ON THIS COMMITTEE OR AGREED TO
SERVE, THIS WAS AN INDETERMINANT
SENTENCE TO FRANCIS AND HANK, WE
APPRECIATE ALL THAT YOU'VE DONE
FOR US.
WE WILL MISS YOU HERE ON MCWG.
WE LOOK FORWARD TO CALLING ON
YOU FOR YOUR CONTINUING ADVICE
AND WISDOM AS TIME GOES ON.
YOU CAN COUNT ON THAT, FOR SURE.
ALSO, LEAVING US AS OUR
EX-OFFICIO PARTNER FROM FDA IS
Dr. KATRINA GWEN-HARDY AND WE
SAY GOOD-BYE TO DAVID MACK
MULLEN.
HE WAS A PROGRAM OFFICER AS NIMH
AND CO-LEAD OF OVERSEEING OUR
NON-INVASIVE NEURO MODULATION
PORTFOLIO.
HE HAS A LOT OF GREAT INTERESTS
THAT ARE VERY WELL ALIGNED WITH
BRAIN AND SO THE SAD NEWS IS
THAT HE IS LEFT US AT NIH BUT
THE GREAT NEWS IS HE IS MOVED ON
TO A NEW ROLE AT THE FOOD AND
DRUG ADMINISTRATION AS DIRECTOR
OF OFFICE OF NEUROLOGICAL AND
FISCAL MEDICINE DEVICES OR OHT5
WITHIN THE FDA AND THIS IS THE
OFFICE THAT WE WORK WITH QUITE A
BIT AS WE DEVELOP NEW DEVICES
FOR NEURO MODULATION.
DAVID, WE WELCOME YOU IN YOUR
NEW ROLE.
WE'RE REALLY LOOKING FORWARD TO
WORKING WITH YOU TO DEVELOP AND
DEPLOY IN HUMANS LIFE-CHANGING
THERAPIES.
I CAN'T GIVE UP IN THANKS TO THE
FOLKS I WORK WITH.
THESE ARE THE FOLKS IN THE
OFFICE OF THE BRAIN DIRECTOR AND
THE STAFF CLOSEST TO ME AND THEY
DO A GREAT JOB IN EVERYTHING
THAT THEY DO AND THEY KEEP ME
OUT OF TROUBLE MORE OFTEN THAN
NOT.
ANOTHER THANK YOU TO MICHELLE
JONES-LONDON WHO IS NOT LEAVING
US ENTIRELY BUT SHE'S STEPPING
ASIDE AS TEAM LOW LEAD FOR
TRAINING, INCLUSION AND EQUITY.
A TEAM THAT SHE PLAYED A BIG
ROLE, TOGETHER WITH JAY CHURCH
HILL IN STANDING UP IN 2020
RIGHT AFTER I GOT HERE.
SHE WEARS MANY, MANY VERY
IMPORTANT HATS AROUND NIH AND
NINDS AND THE CHIEF OF THE
OFFICE OF PROGRAMS FOR WORKFORCE
DIVERSITY OR OPEN WD AS WELL AS
CHAIR OF THE NINDS DIVERSITY
WORKING GROUP.
AS SHE EXTENDS HER ROLES IN
THESE VERY IMPORTANT AREAS, WE
LOOK FORWARD TO WORKING WITH
MICHELLE AS WE MOVE FORWARD.
AS MANY OF YOU KNOW, OUR
SCIENTIFIC PROGRAMS ARE
ORGANIZED ACROSS NINE TEAMS AND
THESE ARE THE TEAMS RIGHT NOW.
WE ARE CURRENTLY SEARCHING AND
RECRUITING FOR NEW TEAM LEADS
FOR TEAM C, DAVID IS OF COURSE
HAS JUST LEFT US FOR THE FDA AND
FOR TEAM TIDE FROM THE VACANCY
LEFT BY MICHELLE AND WE HAVE AN
ONGOING SEARCH FOR THE CO-LEAD
FOR NEUROETHICS AND RIGHT NOW
Dr. NINA TSU IS THE TEAM
CO-LEAD TOGETHER WITH JAY
CHURCHHILL.
AND ALL THIS AGAIN WON BE
POSSIBLE WITHOUT THE HUMONGOUS
EFFORTS OF WELL OVER 100 STAFF
ACROSS THE OFFICES AROUND.
I WANT TO GIVE A FEW UPDATES
ABOUT WHAT HAPPENED SINCE WE
LAST MET.
THE NEUROETHICS WORKING GROUP
HELPED US ORGANIZE A WORKSHOP ON
CONTINUING TRIAL
RESPONSIBILITIES.
THIS WAS A TWO-DAY VIRTUAL
WORKSHOP THAT HELD BACK IN MAY.
THE ISSUES AT HAND WERE, WHAT
CAN WE DO OR WHAT DO WE NEED TO
DO?
WHAT CAN WE DO TO SUPPORT HUMAN
SUBJECTS, PATIENTS, HUMAN
PARTNERS, IN DEVICE TRIALS AFTER
THOSE TRIALS ARE OVER.
SO, THE TRIAL DOES NOT END FOR
THE PATIENT BECAUSE THE PATIENT
HAS BEEN PARTICIPATING IN SOME
THERAPY IN MANY CASES, OR IN
CASES THE BRAIN INVOLVING
IMPLANTED DEVICES, WHAT DO WE DO
TO MAKE SURE THOSE PATIENTS ARE
TAKEN CARE OF, GIVEN THEIR
COMMITMENT AND THE GIFT THAT
THEY'VE GIVEN US THROUGH THEIR
PARTICIPATION.
SO, WE BROUGHT IN A VARIETY OF
STAKEHOLDERS, DEVICE
MANUFACTURERS, THE INVESTIGATORS
THEMSELVES, PATIENTS, PATIENT
ADVOCATES AND CAREGIVERS AND
INSURANCE PROVIDERS, CMS, FOLKS
FROM NIH OF COURSE,
REPRESENTATIVES OF INSTITUTIONS
TO TRUE LOW IDENTIFY WITH
GREATER GRANULARITY WHAT THE
ISSUES ARE.
SO, WE HELPED IDENTIFIED SOME OF
THE POST-TRIAL NEEDS.
THE FEW THINGS STRUCK ME AND
REALLY STRUCK HOME FOR ME WERE
THE VOICES OF THE PATIENTS
THEMSELVES.
THE SUBJECTS.
AND THE ISSUE OF POST TRIAL OR
CONTINUED TRIAL RESPONSIBILITIES
DOESN'T GO JUST FOR A FEW YEARS
AFTER SOME OF THESE TRIALS HAVE
ENDED, THEY CAN GO FOR DECADES.
THAT WAS ONE THING THAT REALLY
KIND OF RESINATED WITH ME.
THE FOR MANY TO AGREE TO
PARTICIPATE IN THESE TRIALS,
HAVING, FOR EXAMPLE, AN
IMPLANTED DEVICE A DBS, TO TREAT
SYMPTOMS FROM TRIGGER DEPRESSION
WASN'T JUST A MATTER OF WANTING
TO HAVE A SOMEWHAT BETTER LIFE
FOR MANY OF THESE PATIENTS IT
WAS A MATTER OF LIFE AND DEATH
WEDEATH.WE NEED TO USE THIS INFN
TO SEE IF WE CAN'T FIND WAYS TO
BETTER ACCOMMODATE THEIR POST
TRIAL OR CONTINUING TRIAL CARE.
THERE ARE LIMITS ON US AS THE
FEDERAL GOVERNMENT ABOUT WHAT WE
CAN AND CONDITION FUND BUT IT'S
NOT TO SAY WE'RE NOT LOOKING FOR
SOME SOLUTIONS TO REALLY TAKE
CARE OF THESE PATIENTS WHO ARE
SO CRITICAL FOR WHAT WE DO AND
ONE OF THE THINGS THAT I'VE BEEN
TRYING TO STRESS TO EVERYBODY IS
PERFECTION SOMETIMES IS THE
ENEMY OF BETTER AND WHAT WE NEED
TO DO RIGHT NOW IS JUST DO
BETTER AND HOPEFULLY GET, AS WE
STRIVE TOWARD CLOSER TO
PERFECTION.
WE ALSO HAVE THE BRAIN
INITIATIVE MEETING THAT WAS HELD
VIRTUALLY IN JUNE.
WE HAD HOPED AND PLANNED FOR A
HYBRID MEETING BUT BECAUSE OF
THE LOCAL COVID LEVELS AT THE
NIH CAMPUS, ABOUT A MONTH
BEFORE, THE MEETING WAS TO TAKE
PLACE, HOPEFULLY A HYBRID EVENT,
WE PHYSICALLY COULD NOT HAVE FIT
THE NUMBER OF PEOPLE THAT SIGNED
UP FOR THE EVENT INTO THE SPACE
WE HAD RESERVED.
SO, WITH GREAT WORK BY SAM WHITE
AND TEAM, WE WERE ABLE TOLL
PIVOT TO A FULLY VIRTUAL EVENT
AND SAM WILL TELL YOU ALL ABOUT
THIS AFTER MY TALK HERE.
WE HAD SOME TERRIFIC PLENARY
LECTURES, TRAINING HIGHLIGHT
TALKS, TERRIFIC SYMPOSIUM
COVERING SUBJECTS AND YOU CAN
STILL ACCESS THIS MEETING AT THE
LINK HERE THROUGH 2023.
THROUGH JUNE OF 2023.
UPCOMING, I JUST WANTED TO LET
YOU KNOW ABOUT WHAT WE'RE DOING
IN THE TRAINING SPACE.
WE'VE TALKED ABOUT THE TRAINING
MECHANISMS.
THE F32s, THE D SPAN, F99K00
WITH OUR SISTER PROGRAM THE BLUE
PRINT PROGRAM AND AS WELL AS OUR
K99R00 PROGRAM AND EACH YEAR WE
PUT ON A NEXT GENERATION LEADERS
WORKSHOP SYMPOSIUM TO ASSIST OUR
TRAINEES IN MAKING THE
TRANSITION.
UNFORTUNATELY IT'S HELD
VIRTUALLY BUT THE GOOD NEWS IS
WE'RE STILL DOING BUT BUT THERE
ARE 200 FUTURE LEADERS IN THIS
SLIDE SO I THINK WE WILL BE
MAKING AN IMPACT ON SCIENCE AND
THE MAKE UP OF OUR WORKFORCE AS
THE GENERATIONS CYCLE THROUGH
THESE DIFFERENT FACES AND ONE OF
THE GREAT THINGS ABOUT THESE
PROGRAMS IS NOT ONLY DO THEY
PROVIDE FUNDING TO SUPPORT THESE
FOLKS IN THEIR TRAINING BUT IT'S
BRINGING TOGETHER A COMMUNITY
WITH THE COMMUNITY THAT WE CAN
REALLY BRING ABOUT GREAT CHANGE
ACROSS THE BOARD.
SO, VERY EXCITED ABOUT THAT
COMING UP.
JUST A QUICK UPDATE ON WHERE WE
ARE WITH THE PLAN FOR ENHANCING
DIVERSE PERSPECTIVES AND THE PDP
THIS IS WHERE WE REQUIRE
INVESTIGATORS TO PROVIDE FOR US
A PLAN DETAILING HOW DIVERSE
PERSPECTIVE WILL ADVANCE THEIR
SCIENCE.
WE SAW THE FIRST EIGHT BRAIN FO
ANTI-SEMITISM WITH THE PDP LAST
MAY AND WE HAVE ONE MORE COMING
TO US TO YOU THIS ROUND AND WE
HAD NINE OR TONE COMING FOR
JANUARY.
WE HAVE THE PDP IN 23 AND THAT
NUMBER IS CLIMBING AND WHAT WAS
HYPODERMIC TO BE A PILOT PROJECT
FOR BRAIN BEFORE THE REST OF NIH
JUMPED ON HAS NOW JUST KIND OF
TAKEN ON A LIFE ITS OWN.
RIGHT NOW THE PDP IS
INCORPORATED INTO 36 NON BRAIN
NIH FOAs.
SO, THIS IS REALLY KIND OF TAKEN
HOLD AND WE'LL LEARN, YOU WILL
HEAR MORE ABOUT THIS IN CLOSED
SESSION ABOUT WHERE WE ARE AND
WHERE WE THINK WE ARE IN TERMS
OF PROGRESS TOWARDS OUR GOALS.
JUST A QUICK UPDATE ON WHERE WE
ARE WITH THE BRAIN 2.0
TRANSFORMATIVE PROJECTS.
THEY'VE ALL BEEN LAUNCHED IN
SOME WAY SHAPE OR FORM.
THE PHASE 3 OF THE CELL CENSUS
PROGRAM OR THE BRAIN INITIATIVE
CELL ATLAS NETWORK FOCUSING ON
NON HUMAN PRIMATE OR HUMAN
BRAINS AS WELL AS NON HUMAN
PRIMATE AND MOUSE BRAINS HAS NOW
BEEN LAUNCHED.
THE FIRST AWARDS HAVE JUST
STARTED GOING OUT THE DOOR AND
THE REST OF THEM WILL BE OUT THE
DOOR HOPEFULLY BIT END OF THE
WEEK OR NEXT WEEK SO WEEK
EXCITED ABOUT THAT AND WE'LL
GIVE YOU UPDATES AS THIS PROJECT
GETS LAUNCHED SO KUDOS FOR THE
TEAMS FOR GETTING THIS DONE AND
KUDOS TO THE INVESTIGATORS WHO
WILL BE TAKING US INTO THIS
THIRD, VERY EXCITING PHASE WHERE
WE'RE GOING TO DEVELOP
COMPREHENSIVE ATLASES OF BRAINS
IN PARTICULAR IN HUMANS.
THE NEXT IS THIS ORGANIZES
RESOURCEs FOR BRAIN CELL TYPE
ACCESS ACROSS SPECIES AND IT'S
QUITE A MOUTHFUL.
WE REFER TO THIS THE PRECISION
BRAIN CELL ACCESS AND THIS IS A
PROGRAM TO DEVELOP TOOLS FOR
CELL ACCESS IN RODENT BRAINS AND
HUMAN CELLS AND TISSUE AND
HOPEFULLY ONE DAY IN HUMANS.
FOR NOW, IT WILL GIVE US THE
TOOLS WE NEED TO PRECISELY
ACCESS BRAIN CELL TYPES FOR
TESTING HYPOTHESIS ABOUT HOW
CELLS AND CIRCUITS UNDERLINE
BEHAVIOR.
EVENTUALLY, WE SEE THIS AS A
FOUNDATION FOR DEVELOPING NEW
THERAPIES FOR HUMAN BRAIN
DISORDERS.
WE ARE JUST GO TO GET OUT THE
DOOR OF THE SECOND ROUND OF
AWARDS FOR THESE EARLY
VALIDATION PROJECTS, AS WELL AS
WE HAVE COMING UP ANOTHER
RECEIPT DATE FOR THE
CAPACITY-BUILDING RESOURCE
DISSEMINATING SITES.
SO STAY TUNED ON THAT.
AND THE CONNECTIVITY PROJECT,
THE BRAIN INITIATIVE
CONNECTIVITY BRAIN CONNECTS AND
THE FO ANTI-SEMITISM FOR THAT
WERE PUBLISHED AND THE FIRST SET
OF APPLICATION HAVE COME IN FOR
THE JULY RECEIPT DATE AND WE'LL
BRING THIS TO YOU AT JANUARY
COUNCIL NEXT YEAR.
AND AGAIN, WE NEED TO GIVE GREAT
THANKS TO OUR MEMBERS OF
CONGRESS WHO SUPPORTED THIS
EFFORT WITH CONGRESSLY DIRECTED
FUNDS THAT HAVE ALLOWED US TO EX
SIL RATESELL RATE THE LAUNCH ANH
IT WITH GENEROUS FUNDING.
WE'RE VERY EXCITED ABOUT THAT.
I'M ALSO VERY EXCITED TO TALK
ABOUT A PROJECT THAT WAS NOT
DIRECTLY FUNDED BY BRAIN BUT
IT'S FAIR TO SAY WAS ENABLED BY
THE GREAT EFFORTS OF OUR BICCN
GRANTEES.
AND THIS IS THE SEATTLE
ALZHEIMER'S DISEASE BRAIN CELL
ATLAS THE CAD PROJECT BETWEEN
THE ALAN INSTITUTE AND KAISER
PERMANENTE AND UNIVERSITY OF
WASHINGTON.
ONE OF THE CO PIs IS Dr. ED
LANE AT THE ALAN INSTITUTE WHO
IS MANY OF YOU MAY KNOW, HAS
BEEN LEADING THE EFFORTS TO
CREATE BRAIN CELL ATLASES FROM
NORMAL HUMANS AND THIS IS WHAT
HIS CONTRIBUTION WAS TO THE
BICCN AND USING THAT AS A
FOUNDATION, THE SEATTLE AD
CONSORTIUM JUST RELEASED DATASET
FOR PUBLIC CONSUMPTION BASED ON
SINGLE CELL RNA FROM ONE MILLION
NEURONS AND OTHER BRAIN CELL
TYPES FROM 84 DONORS FROM AGING
PATIENTS AT VARIOUS STAGES OF
THE DISEASE WITH ANOTHER
ANALYSIS TO GO WITH IT.
AGAIN, THE TECHNIQUES THEY USED
IN THESE ANALYSIS WERE BASED ON
BICC UNFUNDED ADVANCES SO WE'RE
PLEASED AND PROUD THAT WE'RE
ALREADY STARTING TO SEE AN
IMPACT IN THE HUMAN DISEASE AND
HOPEFULLY IN THE HUMAN
TRANSLATION SPACE.
SO BASICALLY, USING THE
INFORMATION WE HAVE FROM THE
BICCN AS A SO-CALLED NORMAL
DATASET, NOW THIS INITIAL
DATASET IS RELEASED ON MID
TEMPORAL GUY RUSS SEQUENCES AND
QUITE INTERESTINGLY, PERHAPS
VERY IMPORTANTLY, THEY'RE
FINDING SPECIFIC CHANGES IN CELL
TYPES.
IN PARTICULAR, A MARK DECREASE
IN THE LAYER 5 IN THE CELL TYPES
AS WELL AS INCREASE IN RELATIVE
REPRESENTATION OF ASTRO SITES
AND MICRO PLEA A AND GIVEN THE
GREAT INTEREST RIGHT NOW IN THE
ROLE OF NEURO INFLAMMATION IN
DEGENERATIVE DISEASES, I THINK
THESE STUDIES WILL REALLY
PROVIDE A GREAT FOUNDATION FOR
NOT ONLY IDENTIFYING THE CELL
TYPES INVOLVED AT DIFFERENT
STAGES OF THE DISEASE BUT NOW
THAT WE HAVE A MOLECULAR HANDLE
ON THEM IT COULD GIVE US A WAY
TO UNDERSTAND DISEASE MECHANISM
AND PROGRESSION.
HOPEFULLY ONE DAY WE CAN GET
CLOSER TO PREVENTION AND CURES.
OUR BRAIN INITIATIVE
INVESTIGATORS HAVE BEEN VERY
ACTIVE.
JUST SINCE JANUARY OF THIS YEAR,
WE'VE SEEN 714 PUBLICATIONS FROM
BRAIN-FUNDED PROJECTS.
YOU CAN SEE THE DISTRIBUTION AND
THE KINDS OF JOURNALS, BOTH
SPECIALTY NEUROSCIENCE JOURNALS
AS WELL AS MORE GENERAL
JOURNALS.
THE DISTRIBUTION OF SITES THAT
MIRRORS TO LARGE DEGREE, WHERE
THE FUNDING IS HAPPENING BUT I
DO THINK I THINK SOME FILLING IN
BETWEEN THE MIDDLE SO IT'S GREAT
TO SEE SO FROM 760 PIs ACROSS
700 INSTITUTIONS WHICH WE THINK
THIS IS A GREAT ANT OF
PRODUCTIVITY AND BEYOND JUST THE
NUMBERS, WE'VE ALL SEEN AMAZING
SCIENCE COME OUT OF OUR GRANTEES
AND WE'RE LOOKING FORWARD TO SEE
MORE TO COME.
SO I JUST WANTED TO HIGHLIGHT A
FEW STUDIES THAT HAVE POPPED UP
ON THE RADAR SINCE WE LAST MET.
THEY HAVE GREAT EXCITEMENT FOR
THE FUTURE.
ONE IS THE ABILITY TO RECORD OR
MONITOR ACTIVITY FROM NOT JUST A
FEW BUT MANY, MANY NEURONS NOW
MOVING INTO HUMANS.
SO THE ABILITY TO RECORD FROM
ENSEMBLES IN NEURONS IS CRITICAL
FOR UNDERSTANDING HOW GROUPS OF
NEURONS, IN A CIRCUIT, ACTUALLY
UNDERLINE BEHAVIOR SO PERHAPS
THE SOMEWHAT TIRED ANALOGY BUT I
THINK IF YOU REALLY WANT TO
FULLY APPRECIATE A SYMPHONY YOU
NEED TO LISTEN NOT JUST INFORM A
FEW MEMBERS OF THE ORCHESTRA BUT
THE ENTIRE ORCHESTRA AND
UNDERSTAND HOW THEY WORK AND
PLAY TOGETHER.
SO, USING THE NEU NEUROPIXALS, E
A STUDY FROM MGA WHERE THEY USE
A MODIFIED NEUROPIXELS PROBE
THAT HAS 386 COLLECTABLE
RECORDING SITES ACTIVE SITES AT
A TIME TO RECORD ACTIVITIES IN
INTRA OPERATIVE PATIENTS.
SO, A KEY HERE IS THAT THESE, TO
DO THESE EXPERIMENTS INTRA OPERA
BLEE, MEANS THEY NEED TO WORK
QUICKLY AND ONE OF THE IMPORTANT
FINDINGS THAT THEY CAME ACROSS
WAS THEY COULD START GETTING
GOOD RECORDINGS, SINGLE-UNIT
RECORDINGS WITHIN A FEW MINUTES
OF THE PLACING THE ELECTRODE IN
THE BRAINS.
NOW, WHEN THEY DO THESE
EXPERIMENTS, THEY HAVE TO LIMIT
THE TIME OF THE RECORDINGS FOR
ISSUES OF PATIENT SAFETY, AND
WHAT IS REALLY COOL IS THEY CAN
GET OUT NICE DATA WITHIN JUST A
FEW MINUTES AND RECORD FOR ABOUT
15 MINUTES BEFORE THEY HAVE TO
GET ON WITH THE ACTUAL BUSINESS
AT HAND.
SO HERE THEY CAN RECORD FROM UP
TO 200 STABLE SINGLE UNITS AND
THEY CAN OBSERVE SINGLE UNIT WAY
FORMS AND THEY CAN BE CLASSIFIED
BASED ON SHAPE AND THEY FOUND
OUT THE LOCAL FIELD POTENTIALS
AND SINGLE-UNIT SPIKING ACTIVITY
CO VARIED DURING BRAIN STATES SO
THEY CAN LOOK AT THESE PATIENTS
IN DIFFERENT STATES AWAKE OR
UNDER AN NISHA SO IT'S VERY ANN.
>> THEY RECORD FOR ABOUT I THINK
EIGHT OR ABOUT SHY OF A DOZEN
PATIENTS.
THEY WERE ABLE TO RECORD SINGLE
UNITS FROM UP TO ABOUT 100 UNITS
PER PATIENT AND THE MEAN WAS
ABOUT 50 OR SO AND AGAIN, AS
OBSERVED, FROM THE OTHER STUDY I
JUST SUMMARIZED FOR YOU THEY
COULD DETECT GOOD UNITS WITHIN A
MINUTE OR SO AFTER INSERTION,
AGAIN, VERY, VERY IMPORTANT FOR
DOING THESE INTRA OPERATIVE
RECORDINGS AND THEY CAN FIND THE
SINGLE UNITS, POSITIVELY
CORRELATED FROM UNITS CLOSE TO
EACH AND A NICE ASPECT OF THEY
SPEND TIME IN THE DISCUSSION
TALKING ABOUT THE NATURE OWE
ETHICAL IMPLICATIONS OF THESE
STUDIES AND I THINK IT'S
DEFINITELY WORTH A READ TO SEE
HOW THEY'RE THINKING ABOUT IT
AND HOW THE FIELD NEEDS TO BE SO
IT'S AN ADD BONUS HERE FOR THE
SCIENCE SO VERY, VERY EXCITING
AND WE'RE LOOKING FORWARD TO
SEEING FURTHER ADVANCES HERE AS
THE STUDIES MOVE FROM ANIMAL
MODELS, WHICH HAVE BEEN QUITE
POWERFUL OF COURSE, TO HUMANS
WHERE WE CAN NOW HOPEFULLY GET
HIGHER FIDELITY, HIGHER NUMBERS
RECORDINGS THAT WILL REALLY
ADVANCE ALL THAT WE DO, NOT ONLY
FOR RESEARCH BUT ALSO IN HELPING
TO MAP ACTIVITIES WITH PATIENTS
UNDERGOING THESE SURGERIES.
SO, I'D LIKE TO HIGHLIGHT A
STUDY THAT WAS CARED BY Dr.
ANDREWS WHO WAS A K99 AWARDEE.
SHE TRAINED IN ARNOLD CREEKSTEIN
HE'S LAB AND IS NOW A PROFESSOR
AT ARIZONA STATE UNIVERSITY.
THIS IS EXCITING FOR US TO SEE
THESE SUCCESSES AND SHE'S
WORKING IN A VERY IMPORTANT AREA
WHERE AT THE LOOKED AT
SARS-CoV-2 VIRUS IN HUMAN
TISSUE OTHER FROM DEVELOPING
TISSUE OR IN ORGANOIDS OR
ACTUALLY IN HUMAN CORTICAL
TISSUE AS WELL AND THEY FOUND
THAT SARS-CoV-2, NO MATTER
WHAT MODEL THEY USED WHETHER IT
WAS IN TISSUE OR AN ORGANOIDS,
INFECTED GLIA -- OR ASTROCYTES
BUT NOT THE NEURON THEMSELVES.
THEY FOUND INTERESTINGLY THIS
APPEARS TO BE ACED TO
INDEPENDENCE SO THESE ASTROCYTES
THAT WERE EFFECTIVELY INFECTED
DID NOT EXPRESS ACE-2 BUT CD147
AND DPP4 SO THERE COULD BE AN
ALTERNATE MECHANISM OF BOLSTERS
OTHER STUDIES THAT HAVE SHOWN
THAT SARS-CoV-2 VERY LIKELY
DOES NOT INFECT THE NEURONS
DIRECTLY AND WE NEED TO LOOK AT
VARIOUS INFLAMMATORY PROCESSES
THAT COULD OR ALMOST CERTAINLY
UNDERLYING SYMPTOMS OF LONG
COVID.
JUST A QUICK SUMMARY OF UPCOMING
FUNDING OPPORTUNITIES.
WE HAVE A NEW FUNDING
OPPORTUNITY IN NEXT GENERATION
NONONON EVASIVE IMAGING WHERE WE
HOPE TO IDENTIFY AND SUPPORT
EARLY PHASE STUDIES WHICH IF
SUCCESSFUL, CAN THEN GO ONTO THE
SECOND UH3 PHASE.
THE FIRST OF THE BRAIN BEHAVIOR
QUANTIFICATION AND
SYNCHRONIZATION RFAs IS OUT.
THIS IS FOR THE HUMAN-FOCUSED
STUDIES AND FOR THOSE OF YOU WHO
ATTENDED, THE BBQS WORKSHOP LAST
YEAR, WILL PROBABLY REMEMBER
THAT OUR INTENT IS TO BE PUSHING
BOTH THE HUMAN AND NON HUMAN
STUDIES SO STAY TUNED FOR
UPCOMING FOAs IN THAT AREA.
AND THEN WE HAVE REISSUES AS
WELL FOR THESE VARIOUS PROGRAMS.
YOU CAN LEARN MORE ABOUT THIS ON
OUR WEBSITE OR JUST COME BACK TO
THIS RECORDING LATER AND TAKE A
LOOK.
BRAIN IS ALSO INVOLVED IN
TRAINING OPPORTUNITIES.
THE IMPORTANCE OF TRAINING THE
NEXT GENERATION LEADERS.
WE HAVE GENERAL TRAINING IN THE
AREA OF POSTDOCAL AWARDS.
THE F32 AWARDS AND WE SUPPORT
RESEARCH SUPPLEMENT FOR REENTRY
INTO THE BIOMEDICAL AND
BEHAVIORAL RESEARCH CAREER TRACK
SO THESE ARE -- THAT IS ROLLING
AND THE F32 IS DECEMBER OF THIS
YEAR AND WE HAVE DIVERSITY
FOCUSED MECHANISM FOR BUILDING
OUT OUR WORKFORCE AND WE HAVE
THE BLUE PRINT D SPAN AND THE
F99K00 MECHANISM SO LATER STAGE
GRADUATE STUDENTS TRANSITIONING
INTO POSTDOCS AS I MENTIONED
BEFORE, BRIAN HAS SIGNED ON TO
THIS BLUE PRINT PROGRAM TO TO
EXPAND THE NUMBER OF SLOTS AND
THIS IS A TERRIFIC OPPORTUNITY
TO IDENTIFY AND SUPPORT THE
GREAT TALENT COMING TO THE
PIPELINE AND SOME OF YOU AND
SOME FELLOWS SO KUDOS TO YOU.
NEXT UP IS OR K99-ROO PROGRAM.
AS A DIVERSITY MECHANISM, IT'S
RESTRICTED FOR UNDER REPRESENTED
GROUPS AND WOMEN AND I HOPE
WE'RE MAKING GOOD PROGRESS THERE
IN DIVERSIFYING OUR WORKFORCE.
WE ALSO HAVE -- WE'RE ALSO QUITE
WELCOMING FOR RESEARCH
SUPPLEMENTS TO FUNDED BRAIN
AWARDS TO BRING IN FOLKS FROM
UNDER REPRESENTED GROUPS AND
THESE DIVERS DIVERSE SUPPLEMENTO
A LONG WAY TO GETTING YOUNG
TRAINEES INTERESTED WORKING IN
THE BRAIN SPACE FOR THESE
VARIOUS OTHER TRAINING AWARDS AS
WELL AND WE HAVE OTHER
SUPPLEMENTS FOR RETENTION AND
CONTINUITY SO THIS IS ALL LISTED
OUT ON OUR TRAINING PROGRAMS
WEBSITE.
IN TERMS OF RESEARCH EDUCATION
WE RELEASED OUR REISSUED THIS
R25 RESEARCH EDUCATION RFA AND
THE PURPOSE OF WHICH IS TO
ENCOURAGE APPLICATIONS FOR THE
CONTINUATION OF ON GOING OR
CREATION OF NEW COURSES FOR
SKILLS DEVELOPMENT IN THE BRAIN
SPACE AND THESE PROGRAMS ARE
GENERALLY EXPECTED TO OFFER
HANDS-ON RESEARCH EXPERIENCE
WITH OTHER ASPECTS ADDED ON TO
THAT.
WE ENCOURAGE YOU, FOLKS, TO
THINK ABOUT OR ENCOURAGE OTHERS
TO CONSIDER THESE PROGRAMS.
I THINK THEY CAN REALLY GO A
LONG WAY TO BRINGING NOT ONLY
BRINGING NEW FOLKS TO THE TABLE
AND TO STUDY NEUROSCIENCE BUT
ALSO AS A WAY OF DIVERSIFYING
OUR WORKFORCE AS WELL.
OK, SO, JUST A REMINDER, YOU CAN
STAY UP-TO-DATE ON ALL THESE
EVENTS BY SUBSCRIBING TO OUR
BRAIN BLOG AND VISITING OUR
WEBSITE AND WATCHING THE GUIDE
NOTICES, I DON'T KNOW WHO
MONITORS IT THAT CLOSELY BUT
IMPORTANTLY TO CONNECT WITH YOUR
OWN PROGRAM OFFICER.
THESE ARE ARGUABLY YOUR BEST
RESOURCE AND THEY REALLY ARE
VERY INTERESTED IN HELPING YOU
ALL-OUT TO GET YOU, MAKE YOU THE
MOST COMPETITIVE FOR FUNDING TO
DO YOUR SCIENCE.
SO, WITH THAT, I WILL FINISH UP.
I'D LIKE TO HOLD QUESTIONS UNTIL
AFTER SAM WHITE'S PRESENTATION
ON THE RECAP OF THE BRAIN
MEETING, IF THAT'S OK.
SAM, ARE YOU THERE?
>> I AM.
I JUST MATERIALIZED SO IF
EVERYONE ELSE IS OK I'M GOING TO
TAKE OVER.
I'M GOING TO SHARE MY SCREEN AND
I WILL TRY TO BE QUICK SO THAT
WE CAN REALLY GET TO A TIME FOR
YOU ALL TO ASK US BOTH
QUESTIONS.
WITHOUT FURTHER ADIEU, I BELIEVE
MY SCREEN -- I BELIEVE YOU ARE
SEEING MY TITLE SLIDE?
>> LOOKS GOOD.
>> GREAT.
I'M GOING TO TAKE US THROUGH A
BRIEF DEBRIEF OF THE 2022 BRYN N
MEETING.
THIS IS SOMETHING I WANT TO
INTRODUCE AT THE BEGIN BEGININGI
WILL LOOP BACK TO AT END.
WE DO THESE DEBRIEFS EACH YEAR
BECAUSE WE WANT TO SET OURSELVES
UP FOR A SUCCESSFUL EVENT IN THE
SUBSEQUENT YEARS.
AS YOU LOOK AT ALL OF THIS
INFORMATION AND THINKING ABOUT
YOUR OWN EXPERIENCES, WITH THE
BRAIN MEETING THAT WE JUST HAD
IN JUNE OF 2022, PLEASE DO THAT
WITH THE LENS OF HAVING A EVEN
MORE STELLAR EVENT IN 2023.
SO, FOR A LITTLE BIT OF A RECAP,
SOME OF YOU MAY RECALL THAT THE
BRAIN MEETING USED TO BE CALLED
THE BRAIN INITIATIVE
INVESTIGATORS MEETING OR THE
BRAIN INITIATIVE PRINCIPLE
INVESTIGATORS OR PI MEETINGS.
WE DID GIVE A LOT OF FEEDBACK
OVER THE YEARS THAT THAT WAS
ACTUALLY NOT AS INCLUSIVE AS OUR
COMMUNITY WOULD HAVE HOPED AND
IT WAS MAKING PEOPLE FEEL LIKE
THE MEETING WASN'T FOR THEM.
SO WE REALLY DID A COMPLETE
REBRAND GOING INTO 2022.
IT'S NOW JUST THE BRAIN
INITIATIVE MEETING, WHICH IS
REALLY WHAT IT WAS ALWAYS ALL
ALONG SO WE DROPPED INVESTIGATOR
OR P.I. AND THEN WE ALSO REALLY
PUT A LOT OF EFFORT IN 2022 IN
FOCUS ON ENGAGING THE TRAINEE
AUDIENCES, WHETHER THEY'RE
ALREADY INVOLVED IN NIH
BRAIN-FUNDED GRANTS OR OTHER
BRAIN FUNDING FROM OTHER ASPECTS
OF THE UNITED STATES, FEDERAL
AND NON FEDERAL PARTNERS IN THE
BRAIN INITIATIVE AND AS WELL AS
OTHERS THAT ARE TOTALLY OUTSIDE
THE ESTABLISHED BRAIN COMMUNITY
AND WE ALSO ADDED A THEME FOR
THE MEETING, AND THIS IS
SOMETHING THAT WILL CHANGE EACH
YEAR THEORETICALLY BASED ON THE
CONTENT AND STATUS OF EVERYTHING
IN SCIENCE SO THIS PAST YEAR THE
NEW THEME WAS OPEN SCIENCE AND
NEW TOOLS.
IN ADDITION ON FOCUSING ON
TRAINEES AND BRINGING MORE
PEOPLE INTO THE FOLD FOR THE
BRAIN INITIATIVE, WE REALLY DID
WANT TO FOCUS IN ON DIVERSITY
GOALS AND WE DID THIS VIA TARGET
ADVERTISING AND INVOLVEMENT.
SO, AS I JUST MENTIONED AND I
WILL MENTION AGAIN, AS WE GO
THROUGH THIS PRESENTATION,
PLEASE, IN THE BACK OF YOUR
HEAD, THINKING ABOUT ANY OTHER
DATA GAPS OR QUESTIONS THAT YOU
MIGHT STILL HAVE REGARDING THE
BRYN INITIATIVE MEETING ANNUAL
EVENT AND THAT YOU WOULD NEED TO
SEE ANSWERED IN ORDER TO ENSURE
WE HAVE A STELLAR 2023 EVENT.
SO, TO START, I'M ACTUALLY GOING
TO PLAY A PROMO VIDEO THAT WE
HAD CREATED THIS YEAR AND IT WAS
SOMETHING THAT I WAS PART OF TT
TARGET ADVERTISING I JUST TALKED
ABOUT.
[♪♪] [ MUSIC ]
>> SO, THAT TRIED TO HIGHLIGHT
THE FEATURES OF THE MEETING AND
THERE WERE DIFFERENT ENGAGEMENT
OPPORTUNITIES THAT WERE OUTLINED
IN THAT PROMO VIDEO AND I HAVE
THE SLIDE THAT JOHN HAD JUST
SHOWN YOU.
AS HE MENTIONED, WE HAD SEQUENCE
OF PLENARY PRESENTATIONS BY OUR
ILLUSTRIOUS SPEAKERS.
WE ALSO HAD QUITE A FEW SIM
POSIA AND I WANT TO TAKE A
MOMENT TO HIGHLIGHT THE SCIENCE
COVERED IN THERE.
ON THE FIRST DAY IN THE MORNING,
WE HAD TWO PARA SELL SYMPOSIUM
SESSIONS.
ONE WAS A USER GUIDE TO THE
BRAIN INITIATIVE CELL SENSES
RESOURCE NETWORK AND TOWARDS
MORE DIVERSE PARTICIPANTS IN
HUMAN NEUROIMAGING RESEARCH AND
THE OPPORTUNITIES AND CHALLENGES
AND THEN ON THAT FIRST DAY OF
THE MEETING IN THE AFTERNOON,
ONE GENERATE INTERNAL STATES
ACROSS ORGANISMS AND THE OTHER
COVERED TOWARDS THE RESPONSIBLE
RESEARCH AND INNOVATION OF NOVEL
NEUROTECHNOLOGIES ACROSS
DOMAINS, CONSIDERATIONS OF
AGENCY, RESPONSIBILITY, AND
ACCESS AND THEN WHEN WE SHIFTED
TO DAY TWO OF THE MEETING IN THE
MORNING IS WHEN WE REALLY
HIGHLIGHTED OUR TRAINEE
HIGHLIGHT AWARDEES.
SO THIS YEAR, WE WERE ABLE TO
EXPAND THE TRAINEE HIGHLIGHT
AWARDS SO WE CAN RECOGNIZE EVEN
MORE TRAINEES AND WE HAD TWO
CONCURRENT SESSIONS WERE IN EACH
ONE THERE WERE 15 FINALISTS WHO
GRAVE ELEVATOR PITCHES ABOUT
THEIR WORK SUPPORTING THEIR
BRAIN INITIATIVE PROJECTS.
AND THEN IN THE POSTER SESSION,
ALL OF THEM ALSO PRESENTED A
POSTER AND THEN WE HAD AN
ADDITIONAL 30 HONORABLE MENTION
TRAINEES WHO PRESENTED POSTERS
ABOUT THEIR WORK IN THE
AFTERNOON OF THE SECOND DAY OF
THE MEETING, THE TWO CONCURRENCE
SYMPOSIUM SESSIONS COVERED
BEHAVIOR QUANTIFICATION FROM
TRACKING TO UNDERSTANDING AND
ADVANCING OUR UNDERSTANDING OF
THE BRAIN AND BEHAVIOR THROUGH
CONNECTOMICS.
ALL OF THAT IS A LOT OF SCIENCE
AND IT'S REALLY A GREAT MEETING
FOR US TO CAPTURE THE FULL
BREADTH OF THE INITIATIVE.
AND ALL OF THOSE DIFFERENT
TOPICS REALLY DID ALIGN WITH
THIS THEME OF OPEN SCIENCE IN
NEW TOOLS.
AS JOHN MENTIONED, ALL OF THIS
IS STILL AVAILABLE INTO JUNE OF
2023.
CAN YOU GO TO THE MEETING LINK
THAT IS ON THE SCREEN.
KRISTEN ALSO POSTED IT IN THE
CHAT.
THANK YOU, CHRISTINE.
AS JOHN MENTIONED, WE HAD REALLY
HOPED FOR 2022 TO BE A HYBRID
EVENT.
OF COURSE, COVID HAD OTHER PLANS
AND WE HAD TO DO A PIVOT.
I JUST WANT TO HIGHLIGHT ON THIS
SLIDE, THAT WHEN YOU ARE MAKING
EITHER A HYBRID OR VIRTUAL
EVENTS, YOU HAVE TO DO A LOT OF
SAME PARALLEL PLANNING SO WE
NEED VIRTUAL SPACES FOR PEOPLE
TO ACCESS INFORMATION AS WELL AS
THINKING THROUGH, OH, WHERE ARE
WE GOING TO BE IN-PERSON.
AGAIN, IF ALSO GOING TO BE A
POTENTIAL IN-PERSON COMPONENT
HAVING A MOBILE APP MAKES SENSE
BUT IT WORKED EVEN WHEN THEY
WERE FULLY VIRTUAL, IT GAVE
MEMBER EVEN MORE ACCESSIBILITIES
SO THEY WEREN'T TRAPPED AT THEIR
COMPUTER AT THEIR DESK AND THEY
COULD STILL PARTICIPATE IN THE
MEETING AND MAKE GO FOR A WALK.
SO THIS WAS SOMETHING THAT
REALLY KIND OF, I THINK, HELPED
ENHANCE THE EVENT EVEN THOUGH WE
HAD TO MAKE THAT LAST-MINUTE
PIVOT.
I WILL NOTE THAT WHEN WE DID
MAKE THE PIVOT, WE ACTUALLY SAW
A HUGE JUMP IN OUR REGISTRATION
WHICH SUGGESTS PEOPLE WERE
HOLDING OUT TO SEE HOW THINGS
WILL PLAY OUT, AGAIN, BECAUSE OF
THE UNCERTAINTY OF EVERYTHING IN
OUR COMMUNITIES.
BUT THEN, WHEN WE SHIFTED TO
FULLY VIRTUAL, WE DID HAPPEN TO
SAVE SOME MONEY FOR OUR
TAXPAYERS SO NA IS ALSO GREAT
AND WE DIDN'T LOSE ANY CONTENT.
SO, AGAIN, ABOUT THAT CONTENT,
I'VE TALKED ABOUT A BUNCH OF IT
BUT ONE THING I REALLY WANTED TO
HIGHLIGHT WITH THIS SLIDE THAT
WAS TWO SHIFTS WE MADE FROM
PREVIOUSLY YEARS.
SO, THE FIRST SHIFT WAS THAT WE
REMOVED RESEARCH HIGHLIGHT TALKS
WHICH HAD BEEN AGAIN KIND OF
MORE OF A SIMPOSIA SESSION AND
REPRESENTED OF BRAIN-FUNDED LABS
THAT WOULD HAVE 15-20 MINUTE
PRESENTATIONS TALKING ABOUT
THEIR RESEARCH.
WE'VE HAD THOSE A LOT OVER THE
YEARS AND THE FEEDBACK WE WERE
GETTING WAS JUST THAT THIS WAS
COVERED PLENTY IN THE OTHER SIM
POSE A SESSIONS AND THEY WANTED
TO SEE THE MUCH MORE COHESIVE
SESSION THAT'S HAD A NARRATIVE
ONE COULD FOLLOW.
THIS YEAR WE REMOVED THE
RESEARCH HIGHLIGHT TALK
OPPORTUNITY.
WHEN WE DID THAT, WE WERE ABLE
TO HAVE MORE SIM POISIA AND
HIGHLIGHT THE TRAINEES ON THEIR
OWN AND THEY HAD FOUR SEPARATE
UNOPPOSED POSTER SESSIONS AND AS
YOU MIGHT REMEMBER FROM YEARS
PAST AND THE THE PLACE WHERE
PEOPLE CAN SHARE THE MOST
SCIENCE AND HAVE THOSE
CONVERSATIONS WITH EACH OTHER
AND REALLY DO A LOT OF
NETWORKING.
OF COURSE IT DOESN'T WORK AS
WELL IN A VIRTUAL ENVIRONMENT
BUT WE HAD A PLATFORM THIS YEAR
THAT SEEMED TO WORK THE BEST IN
A VIRTUAL SPACE OF ALL PLATFORMS
WE'VE TRIED TO USE.
WE HAD OVER 460 POSTERS SOME
COULD BE DYNAMIC POSTERS AND
SOME MORE STATIC POSTERS LIKE
THE PDF OR SOMETHING YOU WOULD
PRINT OUT FOR A MEETING AND THIS
IS SOMETHING WE'RE GOING TO
CONTINUE BECAUSE PEOPLE REALLY
EVEN WANTED MORE TIME TO TALK TO
EACH OTHER ABOUT THE SCIENTIFIC
CONTENT THAT WAS COVERED IN
AWFUL THESE POSTERS.
SO, AS WE'VE ALREADY MENTIONED,
YOU CAN STILL ACCESS EVERYTHING
ON DEMAND AND EVEN PEOPLE WHO
HAVE NOT REGISTERED FOR THE
MEETING, YOU CAN STILL REGISTER
AFTER THE FACTS SO THAT YOU CAN
ACCESS THE MATERIALS.
WE ALSO HAVE A LOVELY MEETING
SUMMARY THAT HAS BEEN WRITTEN IN
POSTED ON OUR BRAIN INITIATIVE
ALLIANCE WEBSITE THAT WE SHARE
WITH OUR BRAIN INITIATIVE
ALLIANCE PARTNER ORGANIZATIONS
BOTH FEDERAL AND NON FEDERAL
THAT REALLY GIVES A FANTASTIC
DISCUSSION OF ALL OF THE
CONTENTS AND THE SPEAKERS, THE
GOALS OF THE DIFFERENT SESSIONS.
SO, AS WE LOOK AT PARTICIPATION
THIS YEAR, WE ACTUALLY SAW SOME
IMPROVEMENTS.
I REEL WANTED TO TRY TO CAPTURE
THAT IN THIS SLIDE.
ON THE LEFT, WE HAVE A CHART
THAT IS SHOWN THE WEBINAR VIEWS
IN REAL-TIME BY DAY.
FOR THE DIFFERENT PLENARY
SESSIONS, SIMPOSIA SESSIONS,
ESPECIALLY SESSIONS DURING THE
LUNCH BREAK ON DAY ONE AND THIS
IS WHERE WE ANNOUNCED THE BRAIN
INITIATIVE CHALLENGE WINNERS
THAT I WILL TALK ABOUT AND ON
DAY TWO, WE DID A VIEWING OF THE
BRAIN MAPPERS VIDEO WHICH WAS
SOMETHING THAT HAD BEEN CREATED
BY AN OUTSIDE PARTNER AND WE
ALSO WANT TO HIGHLIGHT THE
TRAINEE HIGHLIGHT AWARD VIEWS.
THESE WEREN'T ON DAY ONE BUT
THEY WERE ON DAY TWO AND THERE
WERE SOME ADDITIONAL SPECIALTY
AND FOCUS SESSIONS THAT HAPPENED
AT THE END OF EACH DAY.
SO IF WE LOOK ACROSS DAY ONE AND
DAY TWO, THERE WASN'T TOO MUCH
ATTRITION.
ON THE RIGHT, YOU SEE A GRAPH
THAT IS COMPARING THIS YEAR TO
LAST YEAR AND GIVING YOU A
COMPARISON.
IN 2023, THE MEETING WAS THROW
DAYS LONG AND WE SAW VERY
SIGNIFICANT ATTRITION ACROSS THE
THROW DAYS AND OF COURSE THE
THIRD DAY BEING THE WORST WHICH
IS ONE OF THE REASONS WHY WE
OPTED TO RECONSTRUCT THE AGENDA
TO HAVE JUST TWO DAYS OF
SCIENTIFIC CONTENT SO, THIS I
THINK IS GOOD IT MEANS WE REALLY
ENGAGE PEOPLE AND PEOPLE STUCK
AROUND AND IT ALSO SUGGESTED
THAT MAYBE WE DON'T NEED THAT
THIRD DAY OF THE MEETING.
SO, AS I MENTIONED, WE ALSO RAN
OUR SECOND BRAIN INITIATIVE
CHALLENGE THIS WAS TARGETING
HIGH SCHOOL STUDENTS TO TROY TO
GET THEM ENGAGE IN THE BRAIN
INITIATIVE, PARTICULARLY IN THE
TOPIC OF NEUROETHICS AND THIS IS
SOMETHING THAT DIFFERENT
NEUROETHICS PARTNERS AND THE
BRYN INITIATIVE ALLIANCE HAVE
ALSO DONE IN PARALLEL.
SO, WE ARE REALLY EXCITED TO
POTENTIALLY WORK WITH THEM MORE
CLOSELY IN THE UPCOMING FISCAL
YEAR ABOUT ANOTHER CHALLENGE, IF
WE CAN RUN IT.
THIS CHALLENGE IS VERY POPULAR.
SO POPULAR IN FACT IT'S ACTUALLY
PICKED UP BY OUR NON FEDERAL
PARTNERS AND USED AS FODDER TO
HELP ENGAGE CONGRESS ON THE
HILL.
WE'RE GRATEFUL THEY'VE BEEN
PAYING ATTENTION AND ARE EXCITED
TO SHARE THE INTEREST OF THE
YOUTH IN THE UNITED STATES IN
THE BRAIN INITIATIVE IN OUR
TOPICS THAT WE COVER IN BRAIN
WITH THE CONGRESSIONAL PARTNERS
ON THE HILL.
THIS YEAR, WE HAD FOUR VIDEO
WINNERS AND SIX ESSAY WINNERS.
YOU CAN FIND ALL OF THIS
INFORMATION ON-LINE AND KRISTEN
JUST POSTED THE LINK IN THE
CHAT.
BUT IF YOU ARE NOT ABLE TO
ACCESS THE CHAT, JUST SIMPLY GO
TO CHALLENGE.GOV AND YOU CAN
SEARCH FOR BRAIN INITIATIVE AND
YOU CAN ACTUALLY FIND
INFORMATION ABOUT THE 2022
CHALLENGE AS WELL AS THE VERY
FIRST PILOT CHALLENGE WE RAN IN
2021.
WE ALSO CONTINUED AS A METHOD OF
VERY FOCUSED ENGAGEMENT IN AN
EFFORT TO REACH A MUCH BROADER
COMMUNITY, EVEN THOUGH IT'S
OUTSIDE OF BRAIN, OUR ANNUAL
SHOW US YOUR BRAIN PHOTO AND
VIDEO CONTEST SO THIS CONTENTS
WE HAVE RUN FORT PAST FEW YEARS
NOW AND COMPARED TO 2021 WE SAW
A LOT MORE ENGAGEMENT THIS YEAR.
WE ALSO ADJUSTED HOW THE
SUBMISSION PROCESS GOES FOR
THOSE WHO HAVE WONDERFUL
GRAPHICS OR VIDEOS.
THERE ARE TWO EXAMPLES OF THE
FIRST PLACE VIDEO WINNER AND THE
FIRST PLACE PHOTO WINNER ON THE
SCREEN RIGHT NOW.
AND WE ALSO CHANGED HOW PEOPLE
WERE ABLE TO ENGAGE WITH THE
SUBMISSIONS AND VOTE.
AND IN DOING SO, WE ACTUALLY SAW
A HUGE INCREASE AND THE AMOUNT
OF ENGAGEMENT AND EVIDENCED BY
THE FACT THAT EACH ENTRY THAT WE
DID HAVE, HAD OVER 300 VOTES AND
SOME OF THEM HAVE OVER 700
VOTES.
SO, I WANT TO ALSO NOTE THIS IS
NOT JUST A ONE AND DONE KIND OF
THING, ALL OF THE FANTASTIC
SUBMISSIONS THAT WE GET WE'RE
ABLE TO USE IN SUPPORT OF
ADVERTISING THE EXCITING SCIENCE
THAT HAPPENS IN THE BRAIN
INITIATIVE.
WE CREATE A CALENDER AND THERE
WILL BE ONE FOR 2023 COMING OUT
IN THE NEXT COUPLE OF MONTHS AND
THIS IS ALSO SOMETHING THAT IS
PICKED UP BY THE NIH DIRECTOR
ACTING DIRECTOR AT THE MOMENT
AND USED IN THEIR ANNUAL BLOG.
SO, I'M GOING TO SHIFT GEARS A
LITTLE BIT AND GO INTO SOME
ANALYSIS THAT WE HAVE DONE USING
THE REGISTRATION DATA THAT WE
HAVE.
SO IF WE LOOK AT THE MAKE UP OF
THE PEOPLE WHO ATTEND THE BRAIN
MEETING EACH YEAR, WE DO OF
COURSE HAVE SOME PEOPLE WHO ARE
IN FACT FUNDED BY THE FEDERAL
GOVERNMENT AS WELL AS OUR NON
FEDERAL PARTNERS WHO ARE ALL
INVESTING MONEY INTO BRAIN.
THE PEOPLE WHO ARE FUNDED
RELATIVE TO THOSE WHO EITHER OPT
TO NOT SHARE THEIR FUND OR DON'T
KNOW SO MUCH ABOUT THE FUNDING
AND I'M THINKING OF OUR TRAINEE
POPULATION VERSUS PEOPLE LIKE ME
WHO ARE FEDERAL EMPLOYEES AND
WOULDN'T PUT FUNDING IN HERE.
THERE ARE LOWER NUMBERS THAN ONE
MIGHT EXPECT WHICH IS KIND OF
INDICATED BY THE ASTERISK ON THE
TABLE ON THE BOTTOM LEFT.
WE DO SEE THAT THERE'S KIND OF
WOBBLE IN THE NUMBER OF PEOPLE
WHO ARE FUND BID BRAIN.
THAT'S NOT A BAD THING.
IT MEANS THAT WE ARE ACTUALLY
EXPANDING THE NET OF PEOPLE WHO
PARTICIPATE IN THIS MEETING.
SO THAT HAS BEEN ONE OF OUR
GOALS AND THAT IS GOOD.
IF IT WERE ONLY PEOPLE FUNDED BY
BRAIN IT WOULD AGAIN BE VERY A
ISOLATED EVENT AND THAT'S NOT
OUR GOAL OF LATE.
OF COURSE, IF YOU LOOK AT THE
GRAPH ON THE RIGHT, WE SEE THAT
NIH DOES HOST THIS EVENT ON BOW
HALF OF THE UNITED STATES BRAIN
INITIATIVE EACH YEAR AND WE DO
HAVE A LOT OF THE FUNDING THAT
WE PUT INTO THE EXTRAMURAL
SCIENTIFIC COMMUNITY FOR THE
BRAIN INITIATIVE SO MOST PEOPLE
INDICATE NIH FUNDING BUT WE DO
ALSO SEE QUITE A BIT OF FUNDING
FOR OUR OTHER FEDERAL PARTNERS
AND ALSO OUR NON FEDERAL
PARTNERS IN BRAIN.
WHEN WE ALSO LOOK AT MAKE UP OF
OUR REGISTRANTS, WE GROUPED
PEOPLE BY SCIENTISTS, TRAINEES,
OR OTHER, WHICH IS A VERY LARGE
CATCH-ALL.
WHEN WE DO THE WORD SCIENTIST,
THAT IS KIND OF PURPOSEFUL.
IT'S NOT TO SAY TRAINEES ARE NOT
SCIENTISTS, BUT THIS IS
SOMETHING THAT AGAIN WE ALWAYS
TRY TO THINK ABOUT EACH YEAR
ABOUT HOW ARE WE PHRASING
THINGS, IS IT INCLUSIVE TO ALL
DIFFERENT NEWCOMERS TO THIS
MEETING BUT IN THIS CASE WHEN WE
DO SIGNISTS, WE'RE THINKING
ABOUT THE SPECTRUM OF PEOPLE WHO
HAVE FINISHED THEIR EDUCATION
AND ARE ENGAGING IN SCIENCE.
THESE AREN'T JUST THE PIs OF
GIANT LABS, THIS COULD BE STAFF
SCIENTISTS, CLINICAL SCIENTISTS
AND ALL SORTS OF DIFFERENT
PEOPLE.
WHEN WE ASKED PEOPLE HOW THEY
IDENTIFY, ASIDE FROM BEING NEURO
SCIENTISTS THIS IS THE MOST
RECENT LAYOUT OF DIFFERENT SUB
SPECIALITIES THAT PEOPLE HAVE
AND THIS IS FOLLOWING A PATTERN
OF OTHER YEARS WHERE WE HAVE
BEEN SEEING AN INCREASE IN THESE
TOP THREE ENGINEERING,
PHYSIOLOGY OR SYSTEM BIOLOGY AS
WELL AS PSYCHOLOGY OR BEHAVIORAL
SCIENCES AND WHEN WE LOOK AT THE
TRAINEES IT'S NOT THE SAME
MATCH.
SO, ENGINEERING CONTINUES TO BE
SOMETHING THAT IS INCREASING IN
TERMS OF HOW OUR
SCIENTIFICALLY-MINDED PEOPLE WHO
COME TO THE MEETING ARE
IDENTIFIED AND IF YOU LOOK, WE
SEE THAT TRAINEES ARE NOT AS
LIKELY TO AND EXPERIENCE AND
THEY DO INDICATE PSYCHOLOGY OR
BEHAVIORAL AND AS WITH THE
SCIENTISTS THE NEXT ONE IN LINE
WAS BIO CAM OR MOLECULAR AND
CELLULAR BIOLOGY AND SOMETHING
TO THINK ABOUT IS AGAIN, BRAIN
CAN BE TRANCE DISCIPLINARY AND
THIS IS REFLECTING THAT.
CENTER ASK WE ALWAYS ASK FOR
EVERYONE'S FEEDBACK.
IF YOU HAVE PARTICIPATED OR NOT
AND YOU ARE GOING TO NEWLY
REGISTER AND LOOK AT THE
CONTENT, PLEASE, PLEASE GIVE US
FEEDBACK ABOUT THE PLATFORM, THE
CONTENT AND SESSIONS AND THERE'S
A LOT OF DIFFERENT WAYS TO DO
THIS.
IF YOU LOG INTO THE SYSTEM AND
WATCH A GIVEN SESSION THERE'S A
FEW YEA QUESTIONS RIGHT THERE WH
THE DECISION.
ON THE LEFT MENU WHEN YOU LOG IN
A LARGE ACCUMULATION OF
DIFFERENT OPPORTUNITIES FOR
FEEDBACK THAT YOU CAN PICK AND
CHOSE FROM AND TO HIGHLIGHT JUST
A COUPLE FIELD GOOD MOMENTS WHEN
WE DO ASK PEOPLE WHETHER THEY
ENJOY THE MEETING AND WHAT WERE
THEY SATISFIED WITH WHAT WE DID,
THE VAST, VAST MAJORITY OF
RESPONDENTS INDICATED THAT
THEY'RE SATISFIED OR VERY
SATISFIED AND WHEN WE ALSO ASKED
WHY DO PEOPLE JOIN, IT CONTINUES
TO BE THE CASE THAT MOST PEOPLE
PARTICIPATE IN OUR MEETING
BECAUSE THEY WANT TO LEARN MORE
ABOUT RESEARCH AND SCIENTIFIC
DISCOVERIES AND FINALLY, WE DO
KEEP CONTENT ON DEMAND, AGAIN,
THIS IS AN EFFORT TO REALLY
MAINTAIN ACCESSIBILITY AND WE
SEE THAT A LOT OF PEOPLE ARE
LIKELY TO COME BACK IT ROW VISIT
THE CONTENT AND OVER THE COURSE
OF THE YEAR.
I TRIED TO GO AS FAST AS I
COULD.
I'M SEEING THAT WE'RE KIND OF
GETTING TO TIME BUT YOU KNOW, WE
HAVE SOME KEY TAKEAWAYS ON THIS
SCREEN.
I'VE ALREADY TOUCHED ON ALL OF
THEM.
I REALLY WANT TO KIND OF
REITERATE, FOR THE MULTI COUNCIL
WORKING GROUP, FOR EVERYONE OUT
IN THE BRAIN COMMUNITY, YOU
KNOW, ARE THERE OTHER THINGS
THAT YOU WOULD ASK?
ARE THERE PIECES OF DATA THAT
YOU HAVE THAT YOU WANT TO SEE
THAT YOU WOULD LIKE TO SEE
ANALYZED IN ORDER TO HAVE A
REALLY COLLECTIVELY POSITIVE
EXPERIENCE IN 2023.
SO WITH THAT, I WILL STOP MY
SHARE ZOO WE SO WE CAN GO TO Q.
CAN YOU PLEASE USE THE
RAISE-HAND FUNCTION.
I'M I'M NOT SEEING ANYTHING.
NOW I AM.
>> YEAH, HI, THAT WAS GREAT AND
CONGRATULATIONS ON SUCH A
SUCCESSFUL MEETING I HAD TWO
QUESTIONS, ONE IS CAN YOU TRACK
CLICKS ON THE ON-DEMAND CONTENT
TO SEE WHAT GROUP WE'RE
REACHING.
I THINK IT'S WONDERFUL THAT THE
CONTENT IS AVAILABLE FOR A LONG
TIME ON-LINE, AND I WITHIN DER
IF WE'D HAD BROADER REACH IF WE
COULD INTERESTING THOSE
STATISTICS?
I DON'TRACK THOSE STATISTICS?
>> I AGREE.
WHAT WE DO EACH YEAR IS WE WORK
WITH THE VENDOR WE USE TO TRY TO
CONTINUE PULSE CHECKS TO SEE HOW
VIEWS ARE INCREASING AND IN
TERMS OF FIGURING OUT IF WE CAN
CATEGORIZE THEM, I'M NOT SURE.
I'M THINKING PROBABLY NOT.
I AM HAPPY TO LOOK INTO THAT.
>> I THINK JUST GEOGRAPHICALLY,
WHERE ARE PEOPLE LOCATED AND WHO
ACCESSED THE CONTENT OVER MONTHS
FOLLOWING THE MEETING.
THAT WOULD BE GREAT TO SEE.
AND THEN THE OTHER THING I WAS
WONDERING ABOUT, I THINK THAT
THERE ARE MANY PEOPLE WHO
REGISTERED BUT THEN DON'T REALLY
ATTEND THE VIRTUAL SESSIONS AND
DO YOU HAVE DATA ON THAT?
IT LOOKS LIKE YOU HAD GOOD
ATTENDANCE AT LIKE THE PLENARY
TALKS AND THE SYMPOSIA, WHICH IS
GREAT TO SEE.
BUT I WONDER IF THE DATA WE'RE
COLLECTING DOESN'T REFLECT WHO
IS ACTUALLY PARTICIPATING IN THE
MEETING.
>> YES, WE WERE ABLE TO KIND OF
REPEAT A LOT OF THESE ANALYSIS
TO INCLUDE THOSE WHO TRULY DID
ATTEND IN REAL-TIME ON THE TWO
DAYS OF THE EVENT VERSUS THOSE
WHO REGISTERED AND THEN MAYBE
HAD A CONFLICT AND WERE GLAD
THEY WERE GOING TO VIEW IT AFTER
THE FACT.
SO WE CAN DO ALL OF THAT
DIFFERENT NUANCED ANALYSIS.
>> THANK YOU.
HI, SAM.
THANK YOU FOR A GREAT
PRESENTATION.
I HAD A QUESTION BUT FIRST A
COMMENT.
I WAS GLAD TO SEE THE
NEUROETHICS INCLUDED IN THIS IN
TERMS OF DISCUSSIONS.
I HAD A INTERESTING FROM MY
PERSPECTIVE, IN TERMS OF POSTER
SESSIONS, HOW DID YOU -- IT
SEEMS LIKE DISCUSSIONS HAVE
ALWAYS BEEN HARD WITH VIRTUAL
POSTER SESSIONS.
I WONDER WHAT WAS THE SECRET FOR
YOU GUYS AND I HAD ANOTHER
QUESTION BUT THAT WAS MY KIND OF
FACTUAL QUESTION.
HOW ARE YOU ABLE TO HAVE POSTER
DISCUSSIONS OR ENCOURAGE THAT?
>> YEAH, OF COURSE.
SO, THIS YEAR THE PLATFORM THAT
WE USED WAS CALLED I POSTERS.
IN THAT PLATFORM, IT ALLOWS
PEOPLE TO HAVE TARGETED CHATS
WITH EACH POSTER SO THERE IS
LIKE TEXT CHAT OPTIONS THAT
EXIST.
YOU ALSO CAN SCHEDULE VIDEO
CONVERSATIONS WITHIN EACH POSTER
AND SO THE POSTER OWNER IS ABLE
TO PUT IN LET'S SAY THEIR
PREFERRED VIDEO PLATFORM, LET'S
SAY IT'S ZOOM.
THEY CAN PUT THAT IN AND THEY
CAN INDICATE TIMES AND THEY CAN
HAVE EITHER SIGN UPS OR JUST
PLAN TO BE THERE AND ADVERTISE
THAT IN ADVANCE AND ALL
THROUGHOUT.
THERE'S ALSO A FEATURE IN THE
PLATFORM TO ALLOW PEOPLE TO SEND
E-MAIL CORRESPONDENTS ABOUT THE
GIVEN POSTER AND IT'S ALL KIND
OF TIED TOGETHER.
ILIAC KNOWLEDGE LIKE IN-PERSON
EVENTS, SOME ARE MORE POPULAR
THAN OTHERS AND SOMETHING ELSE
WE WOULD REALLY LIKE TO WORK
WITH OUR SCIENTIFIC COMMUNITY ON
IS HOW TO MORE EFFECTIVELY USE
THOSE FEATURES EVEN IN A HATRED
ENVIRONMENT WE'RE GOING TO SEE
BOTH, RIGHT.
IT'S ALWAYS SAD, I REMEMBER,
WHEN YOU SEE THERE'S 50 PEOPLE
AT ONE POSTER AND TWO PEOPLE
COMES TO YOURS AND YOU DID ALL
OF THIS HARD WORK AND AGAINING
V. IT ON DEMAND GIVES PEOPLE
THAT SPOTLIGHT AND THERE IS AN
ABILITY EVEN AFTER THE FACT FOR
PEOPLE TO GO TO A POSTER AND
STILL REACH OUT TO THE POSTER
OWNER.
>> YOU MISSED THE RANDOMNESS IN
THE PARTICULAR AISLES.
>> YOU CAN'T REACH OUT AND GRAB
SOMEONE.
>> RIGHT.
AND I HAD A QUESTION, WE FOUND
THESE MEETINGS AND OTHER
MEETINGS AND THE NIMH COUNCIL
MEETING, THE STRIKING IMPACT OF
HEARING FROM PATIENTS AND FROM
FAMILIES AND I WONDER IF YOU'VE
THOUGHT ABOUT THAT INCORPORATING
THAT IN THIS MEETING BECAUSE IT
SEEMS LIKE A PLACE WHERE THOSE
INDIVIDUALS COULD HAVE A
DRAMATIC IMPACT ON A BROAD RANGE
OF INVESTIGATORS.
>> ABSOLUTELY.
AND I THINK YOU KNOW, REALLY,
TAKING A SECOND TO CONSIDER
STRATEGIC PLANNING AND
IMPLEMENTATION AROUND THIS
PATIENT ENGAGEMENT QUESTION IS
SOMETHING THAT IS REALLY HAVING
A LOT OF TRACTION AT NIH AND
NNINDS.IT'S WHERE WE'LL SEEN MOF
THAT IN YEARS PAST, OF COURSE,
BUT I THINK ABSOLUTELY, TED, IT
WOULD BE FANTASTIC TO HAVE A BIT
MORE TARGETED OPPORTUNITIES AND
OPPORTUNITIES FOR PEOPLE TO
SPEAK, ASK QUESTIONS, HAVE
SESSIONS ALONG THOSE LINES.
SO, NOTED, I AM ON TEAM PATIENT
ENGAGEMENT.
>> OK.
THANK YOU.
>> THANK YOU, JUST A QUICK EVENT
AND EMPHASIS, WE DO EACH YEAR WE
DO WELCOME PROPOSALS FOR
SYMPOSIA SO I WELCOME PEOPLE TO
THINK IF THEY WANT TO PROPOSE ON
TOPICS INVOLVING HUMAN RESEARCH,
BY ALL MEANS.
INCLUDING OUR HUMAN SUBJECT
PARTNERS WOULD BE A GREAT
ADDITION AND PROBABLY GET
ATTENTION ON THE PART OF THE
PROGRAM COMMITTEE FOR FINAL
SELECTION.
THANK YOU.
>> ELBA --
>> HI, THANK YOU.
GREAT PRESENTATION.
THIS IS JUST A WONDERFUL
VICTORY, I FEEL, FOR BRYN AND BD
THE COMMITTEE.
WHEN I LOOK AT THE COMMITTEE IT
ENTICES ME FROM MORE
PERSPECTIVES JUST THE SCIENCE
AND THE SCIENCE GETS TO ME QUITE
A LOT.
I WANTED TO SECOND EVERYTHING
THAT TED AND JOHN HAVE SAID.
AT THE ARO MEETING IT'S
CUSTOMARY TO HAVE PATIENTS GIVE
TESTIMONY OF WHAT IT'S LIKE TO
LIVE WITHOUT HEARING OR BALANCE
AND IT'S -- THEY'RE RIVETING
PRESENTATION AND THEY GIVE
IMMEDIATE A SEE TO THE WORK THEY
DO AND IT TAKES THEM OUT THE
REALM OF THE THEORETICAL.
I HAVE A QUESTION AND
SUGGESTION.
MY QUESTION IS, WHAT ARE YOU
NEEDING YOUR EXPECTATIONS FOR
DIVERSITY.
AND I KNOW WE CAN DEFINE
DIVERSITY BY DISCIPLINE, WHERE
WE LIVE, WHAT WE LOOK LIKE,
ETHNICITY BUT IN TERMS OF THE
BRAIN GOALS FOR DIVERSITY, HOW
ARE WE DOING COMPARED TO LAST
YEAR?
>> JOHN --
>> I DON'T HAVE THE STATS FOR
WHO ACTUALLY SIGNED UP.
WE HAVE BEEN QUITE INTENTIONAL
ABOUT ENSURING THAT OUR SPEAKERS
AND OUR ACTIVE PARTICIPANTS, WHO
SIGN UP, ARE NOT JUST OF ONE
TYPE AS IT WERE.
ANY DEFINED.
BUT I THINK IT GOES BEYOND JUST
WHO IS DOING THE PRESENTING AND
DISCUSSING AND ALSO I THINK HOW
THINGS ARE REFLECTED IN THE
TOPICS.
THERE WAS A TERRIFIC SESSION ON
LOOKING AT SOME OF THE DRIVERS
BEHIND DISPARITIES IN HUMAN OR
IMAGING RESEARCH AND NOT JUST
THAT WE HAVE AN UNDER
REPRESENTATION OF CERTAIN GROUPS
BUT ALSO THE PITFALLS OF
INCLUDING THEM BECAUSE AS WE ALL
KNOW, ANY INFORMATION CAN AND
HAS BEEN WEAPONIZED AGAINST
CERTAIN GROUPS.
SO I THINK THESE DISCUSSIONS ARE
REALLY GOOD TO HAVE AS WELL AS
OTHER DISCUSSIONS AROUND
NEUROETHICS.
HAVE WE ACHIEVED THE GOAL?
CERTAINLY NOT.
ARE WE I THINK MOVING A LITTLE
BIT CLOSER?
I MEAN, YOU KNOW, I JUST WOULD
LOVE TO HEAR IT FROM YOU FOLKS
TO TELL US HOW WE'RE DOING.
IT'S HARD FOR ME TO BE -- I
CANNOT BE OBJECTIVE BUT WE'RE
CERTAINLY BEING VERY INTENTIONAL
AND WE'RE DEMANDING THAT WHEN
PEOPLE PROPOSE SIM POSIA TOPICS
AND SPEAKERS WE'VE GONE BACK AND
SAID LOOK YOUR TOPIC IS FINE BUT
YOU HAVE TO CHANGE YOUR LINEUP.
YOUR LINEUP DUNCE REFLECT THE
GROUP OF SCIENTISTS WE KNOW AT
THE TABLE HERE.
-- IS THIS A DIVERSE MEETING.
I BELIEVE IN ASKING PEOPLE.
IN CLASSES YOU LEARN THAT AS AN
EFFECTIVE WAY TO ENGAGE AND
REALLY GALVANIZE CLASSES.
SO THEN I WANT TO TALK ABOUT THE
CONTENT A LITTLE BIT.
I HAVE A COUPLE OF SUGGESTIONS,
SOME ARE PERHAPS A LITTLE OUT
THERE.
THERE'S A LOT OF CONTENT ON THE
PAGE THAT WOULD BE GREAT FOR
TEACHING.
IT WILL CREATE WORK BUT IT WOULD
BE WONDERFUL TO PICK A FEW OF
THOSE WEBINARS, AND CREATE A
TRANSCRIPT AND MAYBE A TINY
LESSON PLAN THAT COULD BE USED
IN CLASSES.
I THINK THERE ARE THOSE
AVAILABLE OFTEN IN THE ILLEGAL
IS CASE STUDY WEB SITES AND THEY
HAVE THAT AND THEY HAVE NOT USED
THAT IN THE SCIENCES AND THINGS
IN THE AND THEY SIT THERE AND
THAT LITTLE EXTRA COULD MAKE
THEM GREAT TEACHING TOOLS FOR
THE FACULTY WHO ARE STRUGGLING
TO FIND ACTIVITIES TO ENGAGE
THEIR STUDENTS WITH SO THAT'S A
SUGGESTION.
THE OTHER ONE IS A LITTLE MORE
FAR OUT.
I THINK THAT THERE ARE WAYS WE
COULD USE POTENTIALLY TIK TOK
AND INSTAGRAM OR SNAP CHAT TO
DID OUTREACH AND ALSO PUT SOME
FUN INTO THE MEETING.
ESPECIALLY IF PEOPLE COULD
SUBMIT THEIR POSTER AS A LITTLE
TIK TOK VIDEO, THAT COULD BE
SOMETHING THAT MIGHT BE ENGAGING
AND FUN.
AND CREATE A REPOSITORY OF
INFORMATION THAT WOULD BE OUT
THERE THAT A LOT OF PEOPLE OF
ALL KINDS WOULD BE ABLE TO SEE
IN THE FUTURE.
OTHER THAN THAT, GREAT SUCCESS.
WONDERFUL, I'M JUST REALLY
DELIGHTED AT THIS SUCCESS OF
YOUR MEETING AND THE EFFORTS OF
EVERYBODY CONTRIBUTES.
>> THANK YOU SO MUCH, ELBA.
AND I REEL LOVE BOTH OF THOSE
SUGGESTIONS AND I THINK THEY'RE
BOTH THINGS WE CAN LOOK INTO AT
NIH BUT ALSO WITH OUR BRAIN
INITIATIVE ALLIANCE COLLEAGUES
IN TERMS OF BOTH KIND OF THE
EDUCATIONAL AND ENGAGEMENT
OPPORTUNITIES.
WE DO USE SOCIAL MEDIA IN THE
MEETING AND WE HAVE HAD KIND OF
A TWITTER SOCIAL MEDIA WALL AS
IT GOES OVER THE PAST FEW YEARS.
YOU KNOW, THE FEDERAL GOVERNMENT
DOES NOT USE TIK TOK IT'S NOT MY
CHOICE BUT THAT DOESN'T MEAN
OTHER PEOPLE CAN'T AND SO I
THINK THAT REALLY BEING CREATIVE
ABOUT SUGGESTING ALL THE
DIFFERENT WAYS SOMEONE MIGHT
WANT TO SHARE THEIR CONTENT IS
DEFINITELY SOMETHING THAT WE CAN
KIND OF LOOK INTO A BIT MORE.
WE DO ALWAYS ENCOURAGE ANYONE NO
MATTER WHETHER IT'S THE BRAIN
MEETING, ANYTHING BRAIN RELATED,
USE THE HASHTAG STUDY BRAIN.
THAT WORKS ACROSS PLATFORMS.
WE LIKE TO USE THAT TO HELP
AGAIN, KIND OF REALLY KEEP THE
CONTENT COLLECTED.
AND THAT IS SOMETHING THAT WE
USE DURING THE MEETING TOO TO
SEE PEOPLE'S REACTIONS, RIGHT
AND HAVE PEOPLE HAVE THE
OPPORTUNITY TO CALL SOMEONE OUT
TO THEIR POSTER WHICH A COUPLE
PEOPLE DID THIS YEAR BUT AGAIN,
THAT KIND OF GOES BACK TO THE
EDUCATION COMPONENT, RIGHT.
SO WHAT CAN WE DO WITH OUR
SCIENTIFIC COLLEAGUES TO REALLY
HELP THEM SELL THEIR WORK AND
THEIR INTERESTS AND ENTHUSIASM.
WHILE I HAVE THE MIC, I DO NEED
TO MAKE A COUPLE THANK YOUs
THAT YOU SHOULD HAVE DONE ON THE
SLIDES AND I PROMISE I'LL BE
QUIET.
I WANT TO THANK ALL OF THE
OFFICE OF BRAIN DIRECTOR AND IN
PARTICULAR YASMIN CLOTHE WORKED
SO CLOSELY WITH ME, MY TEAM,
WITH OUR BRAIN COMMUNICATIONS
AND ACROSS-OFFICE TEAM TO REALLY
MAKE THE YEAR-LONG
COMMUNICATIONS STRATEGY.
SO I WANT TO ALSO THANK THE
BRAIN COMMUNICATIONS STAFF AT
NIH WHO HAVE REALLY HELPED FINE
TUNE THAT.
OF COURSE, I WANT TO THANK OUR
BRAIN PROGRAM STAFF.
THEY REALLY PARTICIPATE HEAVILY
IN TERMS OF HAVING
REPRESENTATION ON THE PROGRAM
COMMITTEE AND HELPING TO REVIEW
TRAINEE HIGHLIGHT AWARDS AND
APPLICATIONS AND HELPING TO
MODERATE SESSIONS AND THE WHOLE
NINE YARDS AND HELPING TO GET
THE MESSAGE OUT.
I ALSO OF COURSE WANT TO THANK
THE BRAIN INITIATIVE ALLIANCE
PARTNERS THAT WE HAVE AND WE
HAVE ACKNOWLEDGED THEM OF COURSE
ON THE WEBSITE IN THAT PROMO
VIDEO BUT AGAIN, THIS MEETING
TAKES A VILLAGE.
IT'S NOT JUST THE NIH SHOW.
IN PARTICULAR, I REALLY WANT TO
THANK ANDREA, JENNIFER LONG AND
TOY A AND THEY WERE RIGHT WITH
ME IN THE TRENCHES THE WHOLE
TIME MAKING THINGS HAPPEN.
IT WOULD NOT HAVE BEEN POSSIBLE
WITHOUT THEM AND THEN OF COURSE,
OUR CONTRACTOR TEAMS, MULTIPLE,
WHO REALLY MAKE THIS MEETING THE
SCIENTIFIC CONFERENCE THAT IT
IS.
AND THEN WHERE WOULD WE BE
WITHOUT THE CONTENT SO THANK YOU
TO OUR PARTICIPANTS AND OUR
SPEAKERS.
ANY OTHER QUESTIONS?
EITHER FOR SAM FOR JOHN BEFORE
WE MOVE ON TO OUR NEXT
PRESENTATION BY HANK?
OK, HANK, IT'S ALL YOURS.
>> ALL RIGHT.
WELL I AM THE ONLY THING
STANDING IN THIS CASE SITTING
BETWEEN ALL OF US AND A BREAK.
I WILL BE BRIEF.
WHICH ACTUAL LOW ISN'T' BECAUSE
I LAST REPORTED TO YOU BACK IN
MAY AND IN THE COUPLE OF MONTHS
BETWEEN MAY AND NOW, THERE
HASN'T BEEN THAT MUCH THAT
CHANGED OR HAPPENED AT THE NEWG.
I'M GOING TO TALK ABOUT
YESTERDAY'S NEWG MEETING.
WE HOLD OUR MEETINGS IN JANUARY
AND AUGUST JUST BEFORE THE MCWG
MOTELLING, NOT A MEETING IN MAY
AND WE GOT AN UPDATE FROM JOHN.
ALWAYS INFORMATIVE.
WE HAD A PRESENTATION FROM A NEW
MEMBER OF NEWG CAROLINE MONTOJO
WHO IS THE PRESIDENT-C.E.O. OF
THE DANA FOUNDATION, A MAJOR
FUNDING OF NEUROSCIENCE RESEARCH
AND NEUROETHICS RESEARCH.
AND I BELIEVE ARE FOCUSING MORE
ON NEUROETHICS GOING FORWARD.
WE DID A PORTFOLIO ANALYSIS.
WE DO THIS EVERY YEAR.
WE LOOK AT ALL THE BRAIN GRANTS
AND TRY TO SEE WHICH ONES RAISE
ETHICAL ISSUES AND WHAT KINDS OF
ETHICAL ISSUES THEY RAZOR
POTENTIALLY RAISE AND WE'RE
DOING THIS BASED ONLY ON THE
ABSTRACT SO IN MANY CASES, THERE
MAY BE RESOLUTIONS TO SOME OF
THE ETHICAL CONCERNS WE SEE THAT
WE DON'T GET ENOUGH DETAILS
ABOUT TO REALLY UNDERSTAND BUT
INTERESTING LOW TO SEE THEM.
LOTS OF CLASSICAL HUMAN SUBJECTS
QUESTIONS AROUND CONSENT AND AN
INCREASING NUMBERS OF QUESTIONS
ABOUT SOMETHING I PERSONALLY
THINK THE BRAIN INITIATIVE IS
GOING TO HAVE TO HAVE DIFFICULT
TIME WITH AND IT'S THE USE OF
NON HUMAN PRIMATES.
WE ARE GOING TO DO NOW, WE'VE
BEEN DOING THIS FOR FIVE YEARS
AND NOW WE'RE GOING TO DO A
FIVE-YEAR OVER TIME LOOK AT HOW
THOSE ISSUES HAVE CHANGED.
THEY HAVE BEEN IDENTIFIED BY
NEWG MEMBERS LOOKING AT THE
ABSTRACT FROM GRANTS THAT HAVE
BEEN MADE BY THE GRANT
INITIATIVE.
WE WENT AROUND THE TABLE AND
EVERYBODY TALKED ABOUT
NEUROETHICS THEY THOUGHT SHOULD
BE BROUGHT TO PEOPLE'S
ATTENTION.
MOST OF OUR TIME IN OPEN SESSION
AND OTHERWISE, WAS SPENT TALKING
ABOUT THE TRIAL RESPONSIBILITIES
FOR PARTICIPANTS IN TRIALS THAT
INVOLVE IMPLANTABLE NEURAL
DEVICES, I WAS PLEASED THAT JOHN
ALMOST OPENED HIS COMMENTS TODAY
BY TALKING ABOUT THAT.
THIS IS A REAL ISSUE AND THE
WORKSHOP AND PARTICULARLY THE
PARTICIPANTS' DISCUSSIONS AT THE
WORKSHOP BROUGHT IT HOME TO ALL
OF US, HOW IMPORTANT THIS ISSUE.
SOME OF YOU MAY HAVE NOTICED
THIS YEAR WHEN A COMPANY CALLED
SECOND SITE DISCONTINUED A NEURO
PROSTHETIC FOR VISION THAT THEY
HAD DONE AND HOW LOST THE PEOPLE
INVOLVED, THE PEOPLE WHO HAD
THAT WERE, THEY WERE SUDDENLY
CUT OFF FROM THEIR VISION.
IT'S A COMPLICATED ISSUE AND IT
INVOLVES NOT JUST NIH AND
RESEARCH BUT IT INVOLVES THE
HEATH CARE PAYORS INCLUDING CMS
AND IT INVOLVES THE COMPANIES
MAKING DEVICES.
IT INVOLVES THE INSTITUTIONS AND
THE UNIVERSITIES AND OTHERS WHO
ARE SPONSORING THESE TRIALS.
IT'S GOING TO BE HARD, Dr.
SASKIA HENDRIKS FROM THE NIH
CLINICAL CENTER IS WRITING A
PAPER ABOUT IT WITH THE NEWG'S
PARTICIPATION.
NEWG, I'M CONFIDENT WILL GO BACK
TO IT.
I'M SORRY I'M NOT GOING TO BE
AROUND TO SEE THAT.
I'M TERMED OUT OF THE NEWG AT
THE SAME TIME I'M TERMED OUT OF
MCWG.
BUT I TRUST AND EXPECT THAT NEWG
WILL TAKE THIS ISSUE FURTHER
BECAUSE IT'S REALLY ONE OF THE
MOST MOVING AND POWERFUL ISSUES
I'VE SEEN.
MY CONFIDENCE AT THE NEWG WILL
TAKE IT ON STEMS IN PART FROM
THE POSITION AS CO-CHAIR ALONG
WITH NUCLEAR AND ALONG WITH
CHRISTINE GRADY WILL BE FILLED
WITH Dr. NITA FERRAGANI AND I
WANT TO END BY SAYING BOTH IN MY
TIME AT MCWG, I'M THE ONLY
PERSON THAT CALLS THE
MULTI-COUNCIL WORKING GROUP
MCWG, IT'S BEEN FASCINATING AND
EDUCATIONAL AND FOR MY OWN
PERSONALITY, IT'S BEEN FUN.
I'VE ALSO BEEN REALLY IMPRESSED
BY THE GENUINE CONCERN AND
INTEREST THE LEADERSHIP OF BRAIN
AND BRAIN THROUGH OUT TOP TO
BOTTOM HAS SHOWN IN NEUROETHICS.
THOSE OF US ON NEWG, WE
RECOGNIZE THE BRAIN INITIATIVE
IS NOT CREATED IN ORDER TO
PROMOTE NEUROETHICS.
IT'S CREATED IN ORDER TO PROMOTE
THE SCIENCE AND IN ORDER REALLY
TO PROMOTE THE -- TO LEAD TO THE
HUMAN SUFFERING CAUSED BY BRAIN
DISEASES BUT WE THINK THAT
NEUROETHICS PLAYS AN IMPORTANT
ROLE IN BOTH MAKING SURE THAT
IT'S DONE ETHICALLY AND MAKING
SURE IT'S DONE WITH PUBLIC
SUPPORT AND IT'S BEEN GRATIFYING
TO SEE HOW WALTER AND JOHN AND
EVERYONE IN THE BRAIN INITIATIVE
HAS SUPPORTED AND BEEN BEHIND
THE ROLE OF NEUROETHICS.
THANK YOU ALL.
I'M DONE WITH MY REPORT.
QUESTIONS?
DONE WITH MY LAST REPORT.
TO THIS GROUP.
I HOPE IT'S NOT MY LAST REPORT
OVER ALL.
>> THANK YOU, HANK, FOR ALL YOUR
CONTRIBUTIONS NOT JUST HERE AT
MCWG BUT ON THE NEWG.
>> WALTER HAS AT LEAST PROPOSED
ME FOR THE NINDS SO I MAY HAVE
BETHESDA IN MY FUTURE.
NINDS COUNCIL SO BETHESDA MAY BE
IN MY FUTURE.
>> IT ALL DEPENDS ON HOW YOU SEE
OCCUYOU SEEOYOU SEEOYOURSECURIT.
>> EVERYBODY IS EAGER TO GO FOR
A BREAK?
>> IT'S A WISE GROUP.
>> WELL, THANK YOU VERY MUCH.
WE ARE SCHEDULED TO COME BACK AT
1:30.
THAT GIVES US A 20-MINUTE BREAK.
HOPEFULLY THAT WILL BE
SUFFICIENT AND WE'LL SEE YOU IN
A LITTLE WHILE.
>> ON A DIFFERENT LINK.
CLOSED SESSION ON A DIFFERENT
LINK, YEAH?
>> THANK YOU FOR REMINDING ME.
EVERYBODY.