1 00:00:05,240 --> 00:00:10,880 >> I WANT TO WELCOME EVERYONE TO 2 00:00:10,880 --> 00:00:15,080 THE 21st MEET AND I SERVE AS THE 3 00:00:15,080 --> 00:00:19,920 DESIGNATED FEDERAL OFFICIAL FOR 4 00:00:19,920 --> 00:00:21,120 THIS WORK GROUP. 5 00:00:21,120 --> 00:00:22,320 WE HAVE SEVERAL NEW MEMBERS 6 00:00:22,320 --> 00:00:27,240 JOINING US TODAY AND WE HAVE 7 00:00:27,240 --> 00:00:30,880 SEVERAL WHO WILL BE ROTATING OFF 8 00:00:30,880 --> 00:00:34,760 AND DR. NGAI WILL GIVE A FORM 9 00:00:34,760 --> 00:00:36,760 INTRODUCTION AND FAREWELL TO 10 00:00:36,760 --> 00:00:39,320 THOSE WHO ARE LEAVING AND THE 11 00:00:39,320 --> 00:00:41,080 SUCCESS OF THE BRAIN INITIATIVE. 12 00:00:41,080 --> 00:00:43,440 AS A REMINDER FOR MOST AND 13 00:00:43,440 --> 00:00:46,000 INTRODUCTION FOR NEW MEMBERS, 14 00:00:46,000 --> 00:00:47,400 THE MULTI-COUNCIL WORKING GROUP 15 00:00:47,400 --> 00:00:49,920 IS NOT A FORMAL ADVISORY GROUP. 16 00:00:49,920 --> 00:00:52,440 I DOESN'T FALL UNDER THE FEDERAL 17 00:00:52,440 --> 00:00:53,320 ADVISORY COMMITTEE ACT BUT 18 00:00:53,320 --> 00:00:54,640 ESTABLISHED WHEN BRAIN WAS 19 00:00:54,640 --> 00:00:56,400 ESTABLISHED BECAUSE OF THE 20 00:00:56,400 --> 00:00:58,600 RECOGNIZED NEED FOR WIDE RANGING 21 00:00:58,600 --> 00:00:59,760 AND DIVERSE EXPERTISE IN ORDER 22 00:00:59,760 --> 00:01:02,680 TO BE ABLE TO PROPERLY EVALUATE 23 00:01:02,680 --> 00:01:04,360 THE RESEARCH BEING SUPPORTED 24 00:01:04,360 --> 00:01:05,440 UNDER BRAIN. 25 00:01:05,440 --> 00:01:08,360 EACH OF THE 10 INSTITUTES AND 26 00:01:08,360 --> 00:01:09,640 CENTERS HAS A REPRESENTATIVE ON 27 00:01:09,640 --> 00:01:11,800 THE MULTICOUNCIL WORKING GROUP 28 00:01:11,800 --> 00:01:12,720 MOST FROM THE RESPECTIVE 29 00:01:12,720 --> 00:01:14,480 ADVISORY COUNCILS BUT WE ALSO 30 00:01:14,480 --> 00:01:16,360 HAVE SEVERAL AT-LARGE MEMBERS TO 31 00:01:16,360 --> 00:01:21,240 COMPLIMENT THE EXPERTISE OF THE 32 00:01:21,240 --> 00:01:24,600 COUNCIL MEMBERS AND SEVERAL 33 00:01:24,600 --> 00:01:27,440 EX-OFFICIO MEMBERS WHO ARE PART 34 00:01:27,440 --> 00:01:30,080 OF NIHs FEDERAL PARTNERS 35 00:01:30,080 --> 00:01:32,080 INVOLVED IN THE BRAIN 36 00:01:32,080 --> 00:01:32,600 INITIATIVE. 37 00:01:32,600 --> 00:01:34,400 THE MULTICOUNCIL WORK GROUP HAS 38 00:01:34,400 --> 00:01:36,640 SEVERAL FUNCTIONS. 39 00:01:36,640 --> 00:01:38,880 THEY ONGOING OVERSIGHT OF OF THE 40 00:01:38,880 --> 00:01:39,840 SCIENTIFIC VISION AND PROGRESS 41 00:01:39,840 --> 00:01:41,000 OF THE BRAIN INITIATIVE. 42 00:01:41,000 --> 00:01:43,440 WE ASK FOR YOUR FEEDBACK ON 43 00:01:43,440 --> 00:01:45,040 CONCEPT CLEARANCES THAT ARE 44 00:01:45,040 --> 00:01:46,960 EXPECTED TO LEAD TO FUNDING 45 00:01:46,960 --> 00:01:48,440 ANNOUNCEMENTS AND IN CLOSED 46 00:01:48,440 --> 00:01:49,600 SESSION WE WANT YOUR INPUT ON 47 00:01:49,600 --> 00:01:51,360 THE FUNDING PLANS. 48 00:01:51,360 --> 00:01:52,720 WHEN WE TRANSITION TO CLOSED 49 00:01:52,720 --> 00:01:54,960 SESSION, I'LL GO OVER SOME OF 50 00:01:54,960 --> 00:01:56,240 THE OPERATING PROCEDURES AND IT 51 00:01:56,240 --> 00:01:58,640 WILL BEGIN AFTER A 45-MINUTE 52 00:01:58,640 --> 00:01:59,920 BREAK WHEN THE OPEN SESSION 53 00:01:59,920 --> 00:02:01,280 COMPLETES WHICH SHOULD BE AT 54 00:02:01,280 --> 00:02:03,480 AROUND 2:30. 55 00:02:03,480 --> 00:02:05,280 THERE'S A SEPARATE ZOOM LINK FOR 56 00:02:05,280 --> 00:02:06,320 THE CLOSED SESSION THAT WILL 57 00:02:06,320 --> 00:02:07,720 ONLY BE AVAILABLE TO MEMBERS OF 58 00:02:07,720 --> 00:02:09,680 COUNCIL AND GOVERNMENT 59 00:02:09,680 --> 00:02:10,040 EMPLOYEES. 60 00:02:10,040 --> 00:02:12,720 AS A REMINDER, THE OPEN SESSION 61 00:02:12,720 --> 00:02:14,080 IS BEING VIDEO RECORDED AND IT 62 00:02:14,080 --> 00:02:18,120 WILL BE POSTED ON THE NIH AND 63 00:02:18,120 --> 00:02:20,120 BRAIN WEBSITE. 64 00:02:20,120 --> 00:02:22,600 A FEW HOUSEKEEPING ITEMS, PLEASE 65 00:02:22,600 --> 00:02:24,880 MUTE YOUR LINE AND TURN OFF YOUR 66 00:02:24,880 --> 00:02:26,080 VIDEO WHEN NOT SPEAKING. 67 00:02:26,080 --> 00:02:28,440 THIS IS HELPFUL FOR THE 68 00:02:28,440 --> 00:02:28,800 VIDEOCAST. 69 00:02:28,800 --> 00:02:33,760 AND PLEASE TURN ON YOUR VIDEO 70 00:02:33,760 --> 00:02:35,880 DURING THIS DISCUSSION AND USE 71 00:02:35,880 --> 00:02:37,240 THE RAISED HAND OPTION IF YOU 72 00:02:37,240 --> 00:02:38,520 HAVE QUESTIONS AND WE'LL CALL ON 73 00:02:38,520 --> 00:02:40,480 YOU TO UNMUTE YOURSELF. 74 00:02:40,480 --> 00:02:44,920 THIS CHAT WILL NOT BE VISIBLE TO 75 00:02:44,920 --> 00:02:48,480 THOSE ON VIDEOCAST SO WITH THE 76 00:02:48,480 --> 00:02:50,080 RAISED HAND OPTION. 77 00:02:50,080 --> 00:02:53,560 I WANT TO THANK MY COLLEAGUES 78 00:02:53,560 --> 00:03:00,520 WHOSE HARD WORK GOES INTO THIS 79 00:03:00,520 --> 00:03:01,200 MEETING. 80 00:03:01,200 --> 00:03:02,280 THEY'RE WONDERFUL COLLEAGUES TO 81 00:03:02,280 --> 00:03:05,480 WORK WITH AS I'M SURE MOST OF 82 00:03:05,480 --> 00:03:08,600 YOU KNOW FROM INTERACTING WITH 83 00:03:08,600 --> 00:03:13,040 THEM AND UNCOMPROMISING IN THEIR 84 00:03:13,040 --> 00:03:15,880 DETAILS WHICH ALLOWS THIS TO RUN 85 00:03:15,880 --> 00:03:17,120 SMOOTHLY. 86 00:03:17,120 --> 00:03:19,840 WE'LL BEGIN WITH DR. JOHN NGAI 87 00:03:19,840 --> 00:03:22,000 AND THE CO-CHAIR OF THE WORK 88 00:03:22,000 --> 00:03:24,280 GROUP DR. HANK GREELY AND 89 00:03:24,280 --> 00:03:25,640 FINALLY WE'LL BE DISCUSSING A 90 00:03:25,640 --> 00:03:28,240 NEW CONCEPT THAT WILL BE 91 00:03:28,240 --> 00:03:33,800 PRESENTED BY DR. SHUMIN WANG. 92 00:03:33,800 --> 00:03:35,920 >> THANK YOU ALL FOR BEING HERE 93 00:03:35,920 --> 00:03:42,720 AND BIG SHOUT OUT TO YOU, SUSAN 94 00:03:42,720 --> 00:03:43,880 AND OTHERS FOR PUTTING THIS 95 00:03:43,880 --> 00:03:44,920 MEETING TOGETHER. 96 00:03:44,920 --> 00:03:46,440 WE'LL SEE IF IT WILL RUN 97 00:03:46,440 --> 00:03:47,560 SMOOTHLY WE'LL SEE IF I MANAGE 98 00:03:47,560 --> 00:03:50,080 TO RUN IT OFF THE RAILS IF I DO 99 00:03:50,080 --> 00:03:51,880 IT'S NOT THEIR FAULT AT ALL. 100 00:03:51,880 --> 00:03:55,880 I WANTED TO GIVE A BRIEF UPDATE 101 00:03:55,880 --> 00:03:58,000 ON WHAT'S GOING ON IN THE BRAIN 102 00:03:58,000 --> 00:03:58,880 INITIATIVE. 103 00:03:58,880 --> 00:04:01,120 CAN YOU SEE THE PROPER SLIDE? 104 00:04:01,120 --> 00:04:02,400 >> YES. 105 00:04:02,400 --> 00:04:08,400 >> SO JUST A BRIEF UPDATE OF THE 106 00:04:08,400 --> 00:04:10,040 GOINGS ON WHEN WE LAST MET IN 107 00:04:10,040 --> 00:04:10,400 AUGUST. 108 00:04:10,400 --> 00:04:12,200 WE HAVE SOME MEMBERS CYCLING OFF 109 00:04:12,200 --> 00:04:14,880 THIS COMMITTEE. 110 00:04:14,880 --> 00:04:20,880 BEFORE I JOINED BRAIN IN MAY OF 111 00:04:20,880 --> 00:04:23,640 2020 FOLKS WERE APPOINTED TO THE 112 00:04:23,640 --> 00:04:25,400 WORKING GROUP WITH AN INDEFINITE 113 00:04:25,400 --> 00:04:30,960 TERM AND STARTING TO SLOWLY 114 00:04:30,960 --> 00:04:32,280 CYCLE PEOPLE OFF TO GIVE THEIR 115 00:04:32,280 --> 00:04:34,600 LIVES BACK AND THANK YOU FOR 116 00:04:34,600 --> 00:04:40,440 YOUR CONTRIBUTIONS. 117 00:04:40,440 --> 00:04:47,200 CYCLING OFF THIS ROUND IS EMMERY 118 00:04:47,200 --> 00:04:51,320 BROWN AND EVE MARD ARE AND JIM 119 00:04:51,320 --> 00:04:52,400 DESH. 120 00:04:52,400 --> 00:04:54,160 WE APPRECIATE ALL THEY'VE GIVEN 121 00:04:54,160 --> 00:04:54,480 US. 122 00:04:54,480 --> 00:04:56,200 WE'LL BOTH HONOR AND RESPECT 123 00:04:56,200 --> 00:04:57,160 YOUR CONTRIBUTIONS MOVING 124 00:04:57,160 --> 00:05:01,280 FORWARD WITH BRAIN TO MAKE IT 125 00:05:01,280 --> 00:05:04,000 ALL IT'S MINUTE TO BE. 126 00:05:04,000 --> 00:05:05,880 A PROFOUND DEBT OF GRATITUDE TO 127 00:05:05,880 --> 00:05:06,800 ALL OF YOU. 128 00:05:06,800 --> 00:05:11,000 WE'RE ALSO WELCOMING TODAY THREE 129 00:05:11,000 --> 00:05:11,880 I.C. REPS. 130 00:05:11,880 --> 00:05:13,200 EACH OF THE BRAIN INSTITUTE OR 131 00:05:13,200 --> 00:05:15,680 CENTERS HAS A REPRESENTATIVE ON 132 00:05:15,680 --> 00:05:19,200 THE BRAIN MULTICOUNCIL WORK 133 00:05:19,200 --> 00:05:19,400 GROUP. 134 00:05:19,400 --> 00:05:22,280 THE FIRST IS TED ABEL AT THE 135 00:05:22,280 --> 00:05:25,160 UNIVERSITY OF IOWA. 136 00:05:25,160 --> 00:05:26,920 TED WORKS ON MOLECULAR 137 00:05:26,920 --> 00:05:31,880 MECHANISMS OF MEMORY AND THE 138 00:05:31,880 --> 00:05:32,480 MOLECULAR EMPHASIS OF 139 00:05:32,480 --> 00:05:35,000 PSYCHOLOGICAL DISORDER AND 140 00:05:35,000 --> 00:05:36,920 REPRESENTING THE NATIONAL 141 00:05:36,920 --> 00:05:38,040 INSTITUTE OF MENTAL HEALTH 142 00:05:38,040 --> 00:05:39,440 ADVISORY COUNCIL. 143 00:05:39,440 --> 00:05:42,080 WELCOME. 144 00:05:42,080 --> 00:05:46,040 AND WELCOME OUR COLLEAGUE JOHN 145 00:05:46,040 --> 00:05:48,040 MAUNSELL THE DIRECTOR OF THE 146 00:05:48,040 --> 00:05:49,920 GROSSMAN INSTITUTE FOR 147 00:05:49,920 --> 00:05:50,280 NEUROSCIENCE. 148 00:05:50,280 --> 00:05:53,640 AND JOHN'S RESEARCH ARE IN 149 00:05:53,640 --> 00:05:56,320 ATTENTION, VISION AND USING 150 00:05:56,320 --> 00:05:58,080 OPTIGENETICS AND COMPUTATIONAL 151 00:05:58,080 --> 00:06:02,280 TECHNIQUES AND REPRESENTING THE 152 00:06:02,280 --> 00:06:04,680 NATIONAL INSTITUTE FOR 153 00:06:04,680 --> 00:06:06,080 NEUROLOGICAL DISORDERS AND 154 00:06:06,080 --> 00:06:06,480 STROKE. 155 00:06:06,480 --> 00:06:07,800 SORRY, THE CAFFEINE IS KICKING 156 00:06:07,800 --> 00:06:10,080 IN TOO FAST THIS MORNING. 157 00:06:10,080 --> 00:06:14,840 AND THE THIRD REP IS DR. TIRIN 158 00:06:14,840 --> 00:06:17,480 MOORE FROM STANFORD AND LOOKS AT 159 00:06:17,480 --> 00:06:19,360 THE NEURO MECHANISMS OF 160 00:06:19,360 --> 00:06:21,000 VISUAL-MOTOR INTEGRATION. 161 00:06:21,000 --> 00:06:22,640 HE IS HOOVER REPRESENTING THE 162 00:06:22,640 --> 00:06:25,680 NATIONAL EYE INSTITUTE. 163 00:06:25,680 --> 00:06:34,080 WITH ALSO HAVE TWO NEW MEMBERS 164 00:06:34,080 --> 00:06:37,720 EX-OFFICIO MEMBERS FROM NSF. 165 00:06:37,720 --> 00:06:39,280 WELCOME, MICHELLE. 166 00:06:39,280 --> 00:06:40,760 AS WELL AS KATRINA GWINN 167 00:06:40,760 --> 00:06:42,800 REPRESENTING OUR FEDERAL PARTNER 168 00:06:42,800 --> 00:06:44,360 AT THE FOOD AND DRUG 169 00:06:44,360 --> 00:06:45,240 ADMINISTRATION. 170 00:06:45,240 --> 00:06:52,240 SHE IS THE ACTING CHIEF MEDICAL 171 00:06:52,240 --> 00:06:54,080 OFFICER IN THE OFFICE OF CHIEF 172 00:06:54,080 --> 00:06:54,360 TECHNOLOGY. 173 00:06:54,360 --> 00:06:56,200 THESE ARE OUR NEW MEMBERS AND 174 00:06:56,200 --> 00:06:57,080 LOOKING FORWARD TO WORKING WITH 175 00:06:57,080 --> 00:07:01,600 THEM IN THE COMING YEARS. 176 00:07:01,600 --> 00:07:03,680 I'LL START WITH MY IMMEDIATE 177 00:07:03,680 --> 00:07:06,280 LEADERSHIP TEAM AND FOLKS WHO 178 00:07:06,280 --> 00:07:11,680 WORK WITH GREAT SCIENCE GEEKZ 179 00:07:11,680 --> 00:07:16,280 WHO TALK ABOUT AND IT'S WITHOUT 180 00:07:16,280 --> 00:07:22,560 THESE FOLKS NOTHING HERE WOULD 181 00:07:22,560 --> 00:07:25,480 BE POSSIBLE. 182 00:07:25,480 --> 00:07:27,400 THEY'RE TRYING TO KEEP SCIENCE 183 00:07:27,400 --> 00:07:28,960 MOVING TO HELP THEIR FOLKS IN 184 00:07:28,960 --> 00:07:30,520 THE EXTRAMURAL FIELD KEEP THEIR 185 00:07:30,520 --> 00:07:31,880 PROJECTS GOING WHILE MANY OF 186 00:07:31,880 --> 00:07:33,640 WHOM ARE ALSO DEALING WITH 187 00:07:33,640 --> 00:07:36,360 FAMILY AND OTHER ISSUES IMPOSED 188 00:07:36,360 --> 00:07:37,760 BY COVID. 189 00:07:37,760 --> 00:07:40,480 BIG BIG NOTE OF GRATITUDE TO THE 190 00:07:40,480 --> 00:07:44,440 PEOPLE WHO MAKE IT WORK. 191 00:07:44,440 --> 00:07:45,600 OUR SCIENCE IS ORGANIZED INTO 192 00:07:45,600 --> 00:07:46,440 SCIENTIFIC PROJECT TEAMS. 193 00:07:46,440 --> 00:07:50,080 I JUST WANT TO CALL OUT A CHANGE 194 00:07:50,080 --> 00:07:54,080 IN THE NEUROETHICS TEAM NOW 195 00:07:54,080 --> 00:08:04,280 CO-LED BY JAY CHURCHILL AND NINA 196 00:08:04,280 --> 00:08:04,440 HSU. 197 00:08:04,440 --> 00:08:06,720 WHILE WE DO MISS KARA AND ALL 198 00:08:06,720 --> 00:08:08,120 THESE CONTRIBUTED HERE, WE'RE 199 00:08:08,120 --> 00:08:11,520 LOOKING FORWARD TO NINA'S 200 00:08:11,520 --> 00:08:13,480 ONGOING CONTRIBUTIONS SHOES 201 00:08:13,480 --> 00:08:17,800 ALREADY DONE SO MUCH TO PUSH OUR 202 00:08:17,800 --> 00:08:21,400 EFFORTS IN THE NEURO ETHICS 203 00:08:21,400 --> 00:08:22,400 DOMAIN AND OTHER AREAS. 204 00:08:22,400 --> 00:08:24,640 I WANT TO TOUCH BASE IN TERMS OF 205 00:08:24,640 --> 00:08:25,240 OUR BUDGET. 206 00:08:25,240 --> 00:08:27,480 THIS IS THE BUDGET OUTLOOK 207 00:08:27,480 --> 00:08:32,280 STARTING IN 2014 THROUGH 2026. 208 00:08:32,280 --> 00:08:33,880 SO EACH ANNUAL BUDGET IS SPLIT 209 00:08:33,880 --> 00:08:35,280 INTO TWO PIECES. 210 00:08:35,280 --> 00:08:38,000 IN THE RED THIS REPRESENTS THE 211 00:08:38,000 --> 00:08:39,480 SO-CALLED BASE FUNDING WHICH 212 00:08:39,480 --> 00:08:41,920 COMES TO US AS LINE ITEMS IN THE 213 00:08:41,920 --> 00:08:44,400 ANNUAL ALLOCATION TO EACH OF THE 214 00:08:44,400 --> 00:08:47,600 10 PARTICIPATING BRAIN I.C.s. 215 00:08:47,600 --> 00:08:57,680 ON YELLOW, IN AM BER ARE FUNDS 216 00:08:57,680 --> 00:09:01,600 FROM THE CURES ACT WHICH ENDS IN 217 00:09:01,600 --> 00:09:02,040 2026. 218 00:09:02,040 --> 00:09:05,080 THIS IS THE ONLY THING WITH A 219 00:09:05,080 --> 00:09:07,680 HARD ENDING THE CURES ACT FUNDS. 220 00:09:07,680 --> 00:09:12,880 RIGHT HERE WE'RE IN FISCAL '22. 221 00:09:12,880 --> 00:09:16,360 NOTE FROM 2020 TO 2021, WE 222 00:09:16,360 --> 00:09:18,920 RECEIVED FROM CONGRESS A $100 223 00:09:18,920 --> 00:09:20,960 MILLION INCREASE TO OUR BASE 224 00:09:20,960 --> 00:09:21,640 ALLOCATION. 225 00:09:21,640 --> 00:09:24,280 THIS BROUGHT US IN 2021 TO 226 00:09:24,280 --> 00:09:28,040 FUNDING LEVEL OF $560 MILLION. 227 00:09:28,040 --> 00:09:29,920 NOW IN THE BRAIN 2025 REPORT THE 228 00:09:29,920 --> 00:09:31,840 RECOMMENDATION WAS WE SHOULD AIM 229 00:09:31,840 --> 00:09:34,840 FOR A $500 MILLION ANNUAL BUDGET 230 00:09:34,840 --> 00:09:36,600 WHICH IS ABOUT WHERE WERE RIGHT 231 00:09:36,600 --> 00:09:37,080 NOW. 232 00:09:37,080 --> 00:09:37,280 OKAY. 233 00:09:37,280 --> 00:09:40,800 ANOTHER THING TO NOTE IS IN 2023 234 00:09:40,800 --> 00:09:42,760 WE GOT THIS GIGANTIC INCREASE 235 00:09:42,760 --> 00:09:45,080 FROM THE CURES ACT $350 MILLION 236 00:09:45,080 --> 00:09:47,840 ON TOP OF THIS BASE FUNDING SO 237 00:09:47,840 --> 00:09:52,920 IN 2021, THE BASE FUNDING WAS 238 00:09:52,920 --> 00:09:53,240 $460. 239 00:09:53,240 --> 00:09:54,680 IF ALL GOES TO THE FUNDING LEVEL 240 00:09:54,680 --> 00:09:56,560 WE'D HAVE A FUNDING LEVEL NORTH 241 00:09:56,560 --> 00:09:59,280 OF $900 MILLION AND THERE'S A 242 00:09:59,280 --> 00:09:59,440 BUT. 243 00:09:59,440 --> 00:10:04,360 THE BUT IS RIGHT NOW WE'RE IN AN 244 00:10:04,360 --> 00:10:05,960 ONGOING CONTINUING RESOLUTION 245 00:10:05,960 --> 00:10:08,360 CAPS US AT THE BASE BUDGET FOR 246 00:10:08,360 --> 00:10:08,640 2021. 247 00:10:08,640 --> 00:10:10,840 WE HOPE THE BUDGET ISSUE WILL BE 248 00:10:10,840 --> 00:10:12,280 RESOLVED SOON AND CAN GET ACCESS 249 00:10:12,280 --> 00:10:14,480 TO OUR FULL FUNDING LEVEL WHICH 250 00:10:14,480 --> 00:10:18,800 IS PROJECTED, EXPECTED TO BE AT 251 00:10:18,800 --> 00:10:20,720 $612 MILLION WITH THE $152 252 00:10:20,720 --> 00:10:23,800 MILLION ADDITIONAL FROM THE 253 00:10:23,800 --> 00:10:25,080 CURES ACT FUND. 254 00:10:25,080 --> 00:10:25,520 STAY TUNED. 255 00:10:25,520 --> 00:10:27,680 THESE ARE ALL ESTIMATES RIGHT 256 00:10:27,680 --> 00:10:30,400 NOW LOOKING TO THE FUTURE BUT I 257 00:10:30,400 --> 00:10:32,560 ARGUE THE FUTURE LOOKS QUITE 258 00:10:32,560 --> 00:10:33,280 BRIGHT FOR BRAIN. 259 00:10:33,280 --> 00:10:35,200 SO A COUPLE ANNOUNCEMENTS. 260 00:10:35,200 --> 00:10:38,880 I WANT TO DRAW YOUR ATTENTION TO 261 00:10:38,880 --> 00:10:40,000 A FEW THINGS. 262 00:10:40,000 --> 00:10:41,320 SAVE THE DATE. 263 00:10:41,320 --> 00:10:43,680 THE EIGHTH ANNUAL BRAIN 264 00:10:43,680 --> 00:10:45,800 INITIATIVE MEETING HELD JUNE 21 265 00:10:45,800 --> 00:10:46,400 THROUGH 22. 266 00:10:46,400 --> 00:10:49,000 THE MEETING WEBSITE AND ABSTRACT 267 00:10:49,000 --> 00:10:51,080 SUBMISSION SITE WILL BE OPEN 268 00:10:51,080 --> 00:10:51,520 VERY SOON. 269 00:10:51,520 --> 00:10:54,040 AND WE ARE ENCOURAGING ANYBODY 270 00:10:54,040 --> 00:10:55,640 WITH AN INTEREST IN WHAT BRAIN 271 00:10:55,640 --> 00:10:59,800 DOES OR COULD DO OR HOW IT MIGHT 272 00:10:59,800 --> 00:11:01,000 CONTRIBUTE TO BRAIN IS 273 00:11:01,000 --> 00:11:02,040 ENCOURAGED TO PARTICIPATE. 274 00:11:02,040 --> 00:11:03,880 THIS IS NOT JUST FOR BRAIN 275 00:11:03,880 --> 00:11:06,040 INITIATIVE FUNDING INVESTIGATORS 276 00:11:06,040 --> 00:11:08,080 AND CERTAINLY NOT JUST FOR BRAIN 277 00:11:08,080 --> 00:11:08,720 P.I.s. 278 00:11:08,720 --> 00:11:10,360 SO A COUPLE DEADLINES NOTED HERE 279 00:11:10,360 --> 00:11:12,880 IN LATE BREAKING NEWS WE SECURED 280 00:11:12,880 --> 00:11:24,160 THREE KEY NOETE SPEAKERS. 281 00:11:24,160 --> 00:11:27,360 WITH WILL BE MAKING A DECISION 282 00:11:27,360 --> 00:11:29,400 FOR WHETHER THE MEETING WILL BE 283 00:11:29,400 --> 00:11:34,080 HEADLINE IN A FULL VIRTUAL MOTOR 284 00:11:34,080 --> 00:11:36,480 HYBRID MODE COMING IN MARCH. 285 00:11:36,480 --> 00:11:39,880 WAY I THINK IT WILL BE A 286 00:11:39,880 --> 00:11:40,280 FANTASTIC MEETING. 287 00:11:40,280 --> 00:11:42,200 TWO WORKSHOPS I WANT TO DRAW 288 00:11:42,200 --> 00:11:42,920 YOUR ATTENTION TO. 289 00:11:42,920 --> 00:11:47,520 LAST TIME WE TALKED ABOUT THE 290 00:11:47,520 --> 00:11:48,400 SYNCHRONIZATION CONCEPT AND 291 00:11:48,400 --> 00:11:50,040 MENTIONED WE'D BE HOLDING A 292 00:11:50,040 --> 00:11:51,880 SERIES OF WORKSHOPS TO HAMMER 293 00:11:51,880 --> 00:11:54,040 OUT THE DETAILS OF WHERE WE 294 00:11:54,040 --> 00:11:57,520 SHOULD BE GOING. 295 00:11:57,520 --> 00:12:01,880 DELIGHTED TO LET YOU KNOW A 296 00:12:01,880 --> 00:12:03,320 DOCTOR FROM UCLA AND ANOTHER 297 00:12:03,320 --> 00:12:04,800 FROM PRINCETON WILL BE 298 00:12:04,800 --> 00:12:07,800 CO-CHAIRING THIS MEETING. 299 00:12:07,800 --> 00:12:09,840 THANK YOU FOR THAT EFFORT. 300 00:12:09,840 --> 00:12:13,480 THIS GOAL WILL BE SCIENTISTS AND 301 00:12:13,480 --> 00:12:14,600 ENGINEERS ACROSS MULTIPLE 302 00:12:14,600 --> 00:12:16,080 DOMAINS TO SEE WHAT WE CAN 303 00:12:16,080 --> 00:12:18,280 LEVERAGE IN TERMS OF NEW 304 00:12:18,280 --> 00:12:19,920 TECHNOLOGIES TO BETTER 305 00:12:19,920 --> 00:12:25,800 UNDERSTAND BOTH HUMAN AS WELL AS 306 00:12:25,800 --> 00:12:29,280 NON-HUMAN BEHAVIORS AND 307 00:12:29,280 --> 00:12:30,760 SYNCHRONIZE THE DATA TO COME UP 308 00:12:30,760 --> 00:12:32,760 WITH THE CAUSAL BASE OF 309 00:12:32,760 --> 00:12:33,040 BEHAVIOR. 310 00:12:33,040 --> 00:12:34,080 THIS IS IN EARLY MARCH. 311 00:12:34,080 --> 00:12:37,040 THERE'S ALSO UPCOMING A WORKSHOP 312 00:12:37,040 --> 00:12:38,440 TO THE BRAIN ACROSS THE LINE 313 00:12:38,440 --> 00:12:38,640 SPAN. 314 00:12:38,640 --> 00:12:40,480 THIS IS BEING ORGANIZED BY OUR 315 00:12:40,480 --> 00:12:42,280 COLLEAGUES AT NICHD IN 316 00:12:42,280 --> 00:12:44,000 COLLABORATION WITH THE BILL AND 317 00:12:44,000 --> 00:12:45,080 MELINDA GATES FOUNDATION. 318 00:12:45,080 --> 00:12:47,840 IT HAS A KEEN INTEREST IN THIS. 319 00:12:47,840 --> 00:12:49,960 WE HAVE REPRESENTATIVES ON THAT 320 00:12:49,960 --> 00:12:50,800 WORKSHOP AND PLANNING COMMITTEE 321 00:12:50,800 --> 00:12:52,560 AS WELL AND WE SEEK TO IDENTIFY 322 00:12:52,560 --> 00:12:54,680 THE STATE OF THE ART IN TOOLS TO 323 00:12:54,680 --> 00:12:56,280 MEASURE CHANGES IN BRAIN 324 00:12:56,280 --> 00:13:02,040 CELLULAR IDENTITY, CONNECTIVITY 325 00:13:02,040 --> 00:13:03,520 OVER THE LIFE SPAN. 326 00:13:03,520 --> 00:13:08,640 MARK YOUR COLORS -- CALENDARS 327 00:13:08,640 --> 00:13:11,280 AND WE'LL LET YOU KNOW HOW THAT 328 00:13:11,280 --> 00:13:11,480 GOES. 329 00:13:11,480 --> 00:13:13,960 WE'VE TALKED QUITE A BIT ABOUT 330 00:13:13,960 --> 00:13:15,720 ACHIEVING EXCELLENCE THROUGH 331 00:13:15,720 --> 00:13:16,360 INCLUSIVITY. 332 00:13:16,360 --> 00:13:18,560 WE PUBLISHED A POSITION PIECE IN 333 00:13:18,560 --> 00:13:20,160 NEURON LAST OCTOBER AROUND THE 334 00:13:20,160 --> 00:13:21,200 NEUROSCIENCE MEETING. 335 00:13:21,200 --> 00:13:23,480 BRAIN IS COMMITTED TO INCREASING 336 00:13:23,480 --> 00:13:27,240 INCLUSIVITY IN OUR WORKFORCE AND 337 00:13:27,240 --> 00:13:29,040 ALL WE DO WHERE THERE ARE THREE 338 00:13:29,040 --> 00:13:30,560 MAIN PILLARS TO THIS APPROACH. 339 00:13:30,560 --> 00:13:35,560 THE FIRST IS TRAINING THE N 340 00:13:35,560 --> 00:13:37,320 GENERATION IN SCIENTIFIC LEADERS 341 00:13:37,320 --> 00:13:39,880 AND HAVE AWARDS AND OUR 342 00:13:39,880 --> 00:13:44,080 DIFFERENCE TI FOCUSSED F99K00 343 00:13:44,080 --> 00:13:47,200 AND K99R00 PATHWAY TO 344 00:13:47,200 --> 00:13:49,120 INDEPENDENCE AWARDS FOCUSSED ON 345 00:13:49,120 --> 00:13:50,400 WOMEN AND UNDER REPRESENTATIVES 346 00:13:50,400 --> 00:13:50,760 GROUPS. 347 00:13:50,760 --> 00:13:52,600 WE'RE ALSO FUNDING QUITE A FEW 348 00:13:52,600 --> 00:13:55,680 DIVERSITY SUPPLEMENTS TO ALLOW 349 00:13:55,680 --> 00:13:57,680 CURRENTLY FUNDED BRAIN 350 00:13:57,680 --> 00:14:01,640 INVESTIGATORS TO BRING IN 351 00:14:01,640 --> 00:14:03,080 TRAINEES AT VARIOUS LEVELS OF 352 00:14:03,080 --> 00:14:03,960 EDUCATION FROM DIVERSE 353 00:14:03,960 --> 00:14:04,680 BACKGROUNDS TO GET THEM 354 00:14:04,680 --> 00:14:06,520 INTERESTED IN WHAT WE DO IN 355 00:14:06,520 --> 00:14:08,080 BRAIN AND NEUROSCIENCE MORE 356 00:14:08,080 --> 00:14:10,240 GENERALLY AND HOPEFULLY GIVE 357 00:14:10,240 --> 00:14:12,080 THEM A PATH TOWARDS SECURING 358 00:14:12,080 --> 00:14:13,200 INDEPENDENT FUNDING AS THEY MOF 359 00:14:13,200 --> 00:14:14,720 ON IN THESE AREAS. 360 00:14:14,720 --> 00:14:16,200 WE'RE ALSO INTERESTED IN 361 00:14:16,200 --> 00:14:18,040 ENGAGING NEW PARTNERS AND 362 00:14:18,040 --> 00:14:20,800 CAPACITY BUILDING AND HAVE A U24 363 00:14:20,800 --> 00:14:22,920 TO SUPPORT CAPACITY BUILDING AT 364 00:14:22,920 --> 00:14:24,920 MINORITY SERVING AND IDEA 365 00:14:24,920 --> 00:14:27,320 ELIGIBLE INSTITUTION FOR 366 00:14:27,320 --> 00:14:30,080 GENERATING PERFECT CISION CELL 367 00:14:30,080 --> 00:14:32,320 AXIS REGION IN COLLABORATION 368 00:14:32,320 --> 00:14:33,680 WITH TOOL DEVELOPERS AND EXPECT 369 00:14:33,680 --> 00:14:36,000 AND HOP THEY'LL BE INVOLVED IN 370 00:14:36,000 --> 00:14:39,000 THE EARLY R&D EFFORTS AS WELL. 371 00:14:39,000 --> 00:14:40,720 FINALLY WE'RE COMMITTED TO 372 00:14:40,720 --> 00:14:42,240 FOSTERING RESEARCH INCLUSIVE 373 00:14:42,240 --> 00:14:42,600 ENVIRONMENTS. 374 00:14:42,600 --> 00:14:44,480 OUR PLAN FOR ENHANCING DIVERSE 375 00:14:44,480 --> 00:14:45,920 PERSPECTIVES WE TALKED ABOUT 376 00:14:45,920 --> 00:14:47,600 BEFORE, HAVE BEEN ROLLED OUT 377 00:14:47,600 --> 00:14:50,960 INTO NINE-CURRENT BRAIN FOAs AND 378 00:14:50,960 --> 00:14:53,480 THEY'LL BE ROLLED OUT 379 00:14:53,480 --> 00:14:56,200 CONTINUOUSLY AS OUR NEW FOAs ARE 380 00:14:56,200 --> 00:14:58,600 ISSUED OR CURRENT ONES ARE 381 00:14:58,600 --> 00:14:59,160 RE-ISSUED. 382 00:14:59,160 --> 00:15:02,360 THE PDPs BEEN PICKED UP ACROSS 383 00:15:02,360 --> 00:15:02,520 NIH. 384 00:15:02,520 --> 00:15:05,720 THERE'S EIGHT RFAs TO MANY 385 00:15:05,720 --> 00:15:07,280 COUNCIL WITH REQUIREMENTS -- 386 00:15:07,280 --> 00:15:10,040 SORRY, FOR US AND MORE GENERALLY 387 00:15:10,040 --> 00:15:13,920 ACROSS NIH THE PDP IS PICKED UP 388 00:15:13,920 --> 00:15:17,240 ACROSS 10 NON-BRAIN AREAS AND 389 00:15:17,240 --> 00:15:18,960 MECHANISMS INCLUDING THE COMMON 390 00:15:18,960 --> 00:15:20,120 FUND AND VARIOUS I.C.s. 391 00:15:20,120 --> 00:15:22,680 THIS IS ALL WORK IN PROGRESS BUT 392 00:15:22,680 --> 00:15:25,160 I THINK BRAIN HAS LAID OUT A 393 00:15:25,160 --> 00:15:26,680 GOOD STRATEGY FOR INCREASING THE 394 00:15:26,680 --> 00:15:30,880 DIVERSITY AND INCLUSIVITY IN OUR 395 00:15:30,880 --> 00:15:33,640 WORKFORCE WITH AN EYE TOWARDS 396 00:15:33,640 --> 00:15:35,960 ACHIEVING SCIENTIFIC EXCELLENCE. 397 00:15:35,960 --> 00:15:40,760 SO WE'VE HAD INTERESTING 398 00:15:40,760 --> 00:15:53,360 PROJECTS WITHIN BRAIN. 399 00:15:53,360 --> 00:15:59,480 OUR SCHOLAR IS AN ASSISTANT 400 00:15:59,480 --> 00:16:01,320 PROFESSOR AT MICHIGAN STATE AND 401 00:16:01,320 --> 00:16:02,840 THE CHALLENGE IS TO HAVE A WAY 402 00:16:02,840 --> 00:16:07,160 OF HOW IDEAS, THEORIES FIELD 403 00:16:07,160 --> 00:16:11,280 OVER TIME AS A WAY TO PREDICT 404 00:16:11,280 --> 00:16:14,080 WHERE FIELDS MAY BE GOING AND 405 00:16:14,080 --> 00:16:15,640 THERE'S SUCH AN AVALANCHE OF 406 00:16:15,640 --> 00:16:17,360 INFORMATION AND DATA OUT THERE, 407 00:16:17,360 --> 00:16:21,480 PROBABLY NO ONE OF US COULD 408 00:16:21,480 --> 00:16:23,280 FULLY GRASP WHAT'S FULLY OUT 409 00:16:23,280 --> 00:16:24,280 THERE. 410 00:16:24,280 --> 00:16:26,080 MOHAMED TOOK ON THE BRAIN WORKS 411 00:16:26,080 --> 00:16:30,080 PROJECT WHICH IS DEVELOPED A WEB 412 00:16:30,080 --> 00:16:31,480 APPLICATION USING NATURAL 413 00:16:31,480 --> 00:16:32,480 LANGUAGE PROCESSING TO MINE THE 414 00:16:32,480 --> 00:16:36,920 DATA IN THIS CASE THE LITERATURE 415 00:16:36,920 --> 00:16:38,880 TO SEE IF WE CAN IDENTIFY 416 00:16:38,880 --> 00:16:41,040 EMERGING FIELD AND INTERACTIONS 417 00:16:41,040 --> 00:16:47,040 BETWEEN FIELDS FROM THE DATA. 418 00:16:47,040 --> 00:16:48,960 HERE IS WHAT WE CALL THE 419 00:16:48,960 --> 00:16:52,080 DIFFERENT NODE AND TOPICS AND 420 00:16:52,080 --> 00:16:55,440 THE CONNECTION BETWEEN THEM AND 421 00:16:55,440 --> 00:16:57,200 SOME SEEM QUITE INTUITIVE, 422 00:16:57,200 --> 00:17:02,480 OTHERS WONKY AND WE CAN SEE HOW 423 00:17:02,480 --> 00:17:04,640 DIFFERENT FIELDS MIGHT HAVE 424 00:17:04,640 --> 00:17:05,040 EMERGED. 425 00:17:05,040 --> 00:17:07,280 WE HOPE TO GET THIS WRITTEN UP 426 00:17:07,280 --> 00:17:08,640 THIS YEAR AND MAKE IT GENERALLY 427 00:17:08,640 --> 00:17:10,880 AVAILABLE FOR OTHERS TO HELP IN 428 00:17:10,880 --> 00:17:13,320 THEIR ANALYSIS OF THE LITERATURE 429 00:17:13,320 --> 00:17:16,400 AND HOW SCIENTIFIC FIELDS 430 00:17:16,400 --> 00:17:16,640 EVOLVE. 431 00:17:16,640 --> 00:17:20,520 STAY TUNED ON THAT. 432 00:17:20,520 --> 00:17:21,400 OKAY. 433 00:17:21,400 --> 00:17:22,120 AND BUILDING THE RESOURCE WE 434 00:17:22,120 --> 00:17:24,640 BUILD ON BRAINS IS IMPORTANT. 435 00:17:24,640 --> 00:17:26,680 OUR BRAIN INITIATIVE ALLIANCE 436 00:17:26,680 --> 00:17:30,280 WEBSITE STARTED A RESOURCE WHERE 437 00:17:30,280 --> 00:17:34,800 PEOPLE CAN SUBMIT SYNOPSISES AND 438 00:17:34,800 --> 00:17:37,240 TOOLS THEY'RE DEVELOPING AND PUT 439 00:17:37,240 --> 00:17:40,480 UP IN A RESOURCE PAGE AND 440 00:17:40,480 --> 00:17:42,320 THERE'S A WEB FORM AND 441 00:17:42,320 --> 00:17:42,760 NEWSLETTER AS WELL. 442 00:17:42,760 --> 00:17:44,600 IF YOU HAPPEN TO GO OVER TO THE 443 00:17:44,600 --> 00:17:46,400 BRAIN INITIATIVE ALLIANCE 444 00:17:46,400 --> 00:17:48,280 WEBSITE YOU CAN FIND TERRIFIC 445 00:17:48,280 --> 00:17:48,840 INFORMATION ABOUT WHAT'S 446 00:17:48,840 --> 00:17:49,800 AVAILABLE THERE AND WE LOOK 447 00:17:49,800 --> 00:17:52,480 FORWARD TO DEVELOPING THIS AS WE 448 00:17:52,480 --> 00:17:56,080 GO ALONG IN TIME. 449 00:17:56,080 --> 00:17:57,240 TOGETHER WITH OUR OTHER BRAIN 450 00:17:57,240 --> 00:17:58,080 INITIATIVE PARTNERS. 451 00:17:58,080 --> 00:17:59,520 WE HAVE SEVERAL NEW FUNDING 452 00:17:59,520 --> 00:18:00,880 OPPORTUNITIES ON THE STREET. 453 00:18:00,880 --> 00:18:02,080 I'LL GO THROUGH THESE FAIRLY 454 00:18:02,080 --> 00:18:05,080 QUICKLY. 455 00:18:05,080 --> 00:18:09,000 WE HAVE OUR U24 FOR TECHNOLOGY 456 00:18:09,000 --> 00:18:14,680 RESEARCH DISSEMINATION AGAIN 457 00:18:14,680 --> 00:18:15,640 DISSEMINATION AND THAT BEING KEY 458 00:18:15,640 --> 00:18:17,400 AND A NEW NOTICE FOR 459 00:18:17,400 --> 00:18:18,080 TRANSLATIONAL DEVICE. 460 00:18:18,080 --> 00:18:21,800 WE'RE PARTNERING WITH THE BLUE 461 00:18:21,800 --> 00:18:24,600 TOOTH MED TECH PROGRAM TO ASSIST 462 00:18:24,600 --> 00:18:26,280 EARLY STAGE DEVELOPMENT OF BOTH 463 00:18:26,280 --> 00:18:29,320 INVASIVE AND NON-INVASIVE 464 00:18:29,320 --> 00:18:32,840 TECHNOLOGIES FOR INTERVENING AND 465 00:18:32,840 --> 00:18:33,880 MODULATION IN HUMANS. 466 00:18:33,880 --> 00:18:35,280 MUCH OF THE CHALLENGES PEOPLE 467 00:18:35,280 --> 00:18:37,360 HAVE IN DEVELOPING NEW 468 00:18:37,360 --> 00:18:40,080 TECHNOLOGIES IS GETTING THROUGH 469 00:18:40,080 --> 00:18:41,840 EARLY REGULATORY HURDLES AS WELL 470 00:18:41,840 --> 00:18:44,240 AS OTHER TECHNOLOGY DEVELOPMENT 471 00:18:44,240 --> 00:18:46,280 HURDLES AND THE BLUEPRINT MED 472 00:18:46,280 --> 00:18:48,200 TECH PRAC IS DESIGNED TO ASSIST 473 00:18:48,200 --> 00:18:48,960 INVESTIGATORS THROUGH THE EARLY 474 00:18:48,960 --> 00:18:50,040 STAGES. 475 00:18:50,040 --> 00:18:53,240 VERY MUCH LOOKING FORWARD TO 476 00:18:53,240 --> 00:18:55,080 SEEING HOW TO PARTNER WITH 477 00:18:55,080 --> 00:18:58,040 BLUEPRINT IN FACILITATING SOME 478 00:18:58,040 --> 00:19:22,320 STUDIES. 479 00:19:22,320 --> 00:19:23,400 THIS IS SOMETHING WE'LL BE 480 00:19:23,400 --> 00:19:26,000 MAKING DECISIONS ON LATER THIS 481 00:19:26,000 --> 00:19:27,040 SPRING AND HAVE A ROLLING 482 00:19:27,040 --> 00:19:28,480 SUBMISSION PROCESS THROUGH APRIL 483 00:19:28,480 --> 00:19:30,440 OF THIS YEAR. 484 00:19:30,440 --> 00:19:32,120 FINALLY, I'LL TOUCH ON THIS A 485 00:19:32,120 --> 00:19:37,080 BIT LATER IS OUR UPCOMING FOAs 486 00:19:37,080 --> 00:19:39,120 TO SPORT THE BRAIN INITIATIVE 487 00:19:39,120 --> 00:19:39,800 CONNECTIVITY ACROSS SCALES OR 488 00:19:39,800 --> 00:19:42,680 BRAIN CONNECTS PROJECTS. 489 00:19:42,680 --> 00:19:45,480 THESE RFAs WILL BE ISSUED IN THE 490 00:19:45,480 --> 00:19:51,560 SPRING WITH DUE DATES LATER THIS 491 00:19:51,560 --> 00:19:51,800 SUMMER. 492 00:19:51,800 --> 00:19:53,760 OKAY. 493 00:19:53,760 --> 00:19:55,080 I PUBLISHED A COMMENTARY WITH AN 494 00:19:55,080 --> 00:19:59,080 OVERVIEW OF THE SO-CALLED BRAIN 495 00:19:59,080 --> 00:20:03,000 2.0 TRANSFORMATIVE PROJECTS. 496 00:20:03,000 --> 00:20:04,760 THESE ARE PROJECTS THAT WERE 497 00:20:04,760 --> 00:20:07,000 CONCEIVED WITH THE URGING AND IN 498 00:20:07,000 --> 00:20:09,880 COURAGEMENT OF THE BRAIN 2.0 TO 499 00:20:09,880 --> 00:20:12,080 FIND AN STAND UP LARGE PROJECTS 500 00:20:12,080 --> 00:20:15,640 THAT COULD POTENTIALLY TRANSFORM 501 00:20:15,640 --> 00:20:18,680 THE WAY WE CONDUCT RESEARCH AND 502 00:20:18,680 --> 00:20:24,840 APPLY IT TO THE TREATMENT OF 503 00:20:24,840 --> 00:20:30,520 HUMAN BRAIN AND FOCUSSING ON 504 00:20:30,520 --> 00:20:30,960 HUMANS. 505 00:20:30,960 --> 00:20:32,400 THE WHOLE BRAIN MICROCONNECTIST 506 00:20:32,400 --> 00:20:37,680 PROJECT AND THE PROJECT TO 507 00:20:37,680 --> 00:20:40,040 DEVELOP TOOLS FOR PRECISION 508 00:20:40,040 --> 00:20:40,280 ACCESS. 509 00:20:40,280 --> 00:20:42,040 IF YOU READ THROUGH THE 510 00:20:42,040 --> 00:20:45,480 COMMENTARY THE POINT I HOPE WE 511 00:20:45,480 --> 00:20:47,640 MADE WAS A, THE IMPACT THE 512 00:20:47,640 --> 00:20:48,680 PROJECTS MAY HAVE ON 513 00:20:48,680 --> 00:20:49,880 NEUROSCIENCE RESEARCH AND THE 514 00:20:49,880 --> 00:20:56,480 WAY THESE PROJECTS MUTUALLY 515 00:20:56,480 --> 00:20:58,400 SUPPORT EACH OTHER FOR PROJECTS 516 00:20:58,400 --> 00:21:01,040 TO REVOLUTIONIZE THE STUDY OF 517 00:21:01,040 --> 00:21:02,080 THE ANNIVERSARY SYSTEM IN 518 00:21:02,080 --> 00:21:02,480 PARTICULAR. 519 00:21:02,480 --> 00:21:03,880 I SHOWED SOME INVESTIGATION OF 520 00:21:03,880 --> 00:21:05,320 THIS SLIDE IN THE LAST COUPLE 521 00:21:05,320 --> 00:21:05,600 MEETING. 522 00:21:05,600 --> 00:21:06,880 I'LL GIVE A QUICK EVERY VIEW AND 523 00:21:06,880 --> 00:21:11,280 GET TO WHERE WE ARE WITH SOME 524 00:21:11,280 --> 00:21:14,000 BRIEF UPDATES. 525 00:21:14,000 --> 00:21:17,080 THE BRAIN INITIATIVE CELL ATLAS 526 00:21:17,080 --> 00:21:18,560 NETWORK AND WE RECEIVE THE 527 00:21:18,560 --> 00:21:21,080 APPLICATION FOR THIS PROJECT. 528 00:21:21,080 --> 00:21:23,160 THEY'RE BEING REVIEWED THIS 529 00:21:23,160 --> 00:21:24,960 SPRING. 530 00:21:24,960 --> 00:21:32,520 WE'LL BE COMING BACK TO YOU 531 00:21:32,520 --> 00:21:41,200 LATER THIS YEAR. 532 00:21:41,200 --> 00:21:42,800 THE FIRST ROUND HAS BEEN FUNDED 533 00:21:42,800 --> 00:21:47,480 AND THERE'S A CAPACITY RFA FOR 534 00:21:47,480 --> 00:21:50,680 WHAT WE ALREADY RECEIVED THE 535 00:21:50,680 --> 00:21:56,480 FIRST ROUND AND THE CONNECTIVITY 536 00:21:56,480 --> 00:21:58,320 ANALYSIS AND WE'RE EXCITED ABOUT 537 00:21:58,320 --> 00:22:00,240 THE FOAs. 538 00:22:00,240 --> 00:22:05,280 THESE ARE THE THREE PROJECTS IN 539 00:22:05,280 --> 00:22:08,080 FISCAL YEAR AP 21 OF WHAT WE 540 00:22:08,080 --> 00:22:11,280 RECEIVED IN THE BASE FUNDING $60 541 00:22:11,280 --> 00:22:12,600 MILLION WERE SO-CALLED 542 00:22:12,600 --> 00:22:13,680 CONGRESSIONALLY DIRECTED FUNDS 543 00:22:13,680 --> 00:22:15,720 TO ACCELERATE THE PROJECTS. 544 00:22:15,720 --> 00:22:18,720 THESE WERE DIRECTED TOWARDS THE 545 00:22:18,720 --> 00:22:23,160 CELL ATLAS PROJECT AND 546 00:22:23,160 --> 00:22:24,760 ARMAMENTARIAN PROJECT AND LAST 547 00:22:24,760 --> 00:22:29,080 YEAR WE FUNDED APPROXIMATELY $40 548 00:22:29,080 --> 00:22:30,120 MILLION ACROSS 10 AWARDS. 549 00:22:30,120 --> 00:22:32,120 TWO PROJECTS THAT WERE FOCUSSED 550 00:22:32,120 --> 00:22:34,480 ON DEVELOPING SCALABLE TOOLS FOR 551 00:22:34,480 --> 00:22:35,520 STUDYING BIG BRAINS. 552 00:22:35,520 --> 00:22:38,040 THESE WERE FROM ONGOING RFAs WE 553 00:22:38,040 --> 00:22:40,160 HAD BEFORE AND I THINK THIS WILL 554 00:22:40,160 --> 00:22:42,800 HELP US GET A HEAD START ON 555 00:22:42,800 --> 00:22:46,080 DEVELOPING A WHOLE HUMAN BRAIN 556 00:22:46,080 --> 00:22:50,080 CELL ATLAS AND THEN WE APPLIED 557 00:22:50,080 --> 00:22:53,560 $16 MILLION OF THESE FUNDS TO 558 00:22:53,560 --> 00:22:56,920 OUR PROJECTS IN THE AREA OF 559 00:22:56,920 --> 00:22:58,440 PRECISION CELL ATLAS ACCESS, 560 00:22:58,440 --> 00:23:00,280 THREE OF THE FOUR OF THESE WERE 561 00:23:00,280 --> 00:23:03,680 ACTUALLY FROM THE RFA I JUST 562 00:23:03,680 --> 00:23:05,480 DESCRIBED AND WE'RE EXCITE 563 00:23:05,480 --> 00:23:07,000 EXCITED ABOUT WHERE THE PROJECTS 564 00:23:07,000 --> 00:23:07,800 ARE GOING. 565 00:23:07,800 --> 00:23:09,360 MANY THANKS TO OUR FRIENDS ON 566 00:23:09,360 --> 00:23:11,320 THE HILL FOR GIVING US THE EXTRA 567 00:23:11,320 --> 00:23:14,040 FUNDS TO GOT THE PROJECTS 568 00:23:14,040 --> 00:23:15,720 STARTED SOONER RATHER THAN 569 00:23:15,720 --> 00:23:16,000 LATER. 570 00:23:16,000 --> 00:23:19,240 I WANT TO GIVE YOU TWO 571 00:23:19,240 --> 00:23:20,680 HIGHLIGHTS WITH REGARDS TO THE 572 00:23:20,680 --> 00:23:22,000 PROJECTS AND END WITH A BRIEF 573 00:23:22,000 --> 00:23:25,480 UPDATE ON WHERE WE ARE WITH THE 574 00:23:25,480 --> 00:23:27,080 CONNECTIVITY PROJECT. 575 00:23:27,080 --> 00:23:30,520 SO LAST FALL WAS A GOOD ONE FOR 576 00:23:30,520 --> 00:23:30,680 US. 577 00:23:30,680 --> 00:23:32,280 THE BRAIN INITIATIVE CELL CENSUS 578 00:23:32,280 --> 00:23:38,440 NETWORK PUBLISHED ED ED A TRANCHE OF 579 00:23:38,440 --> 00:23:44,840 17 ARTICLES AND 10 ARTICLES IN 580 00:23:44,840 --> 00:23:49,520 SISTER JOURNALS AND THEY SET 581 00:23:49,520 --> 00:23:50,640 THIS STAGE FOR THE COLLABORATION 582 00:23:50,640 --> 00:23:52,440 THAT WILL BE NECESSARY TO STAND 583 00:23:52,440 --> 00:23:54,880 UP A WHOLE HUMAN BRAIN CELL 584 00:23:54,880 --> 00:23:55,160 ATLAS. 585 00:23:55,160 --> 00:23:57,680 I'VE SHOWN MANY OF THIS TO YOU 586 00:23:57,680 --> 00:23:59,000 BEFORE BUT I'LL REPEAT AGAIN 587 00:23:59,000 --> 00:24:02,040 BRIEFLY, WHAT WE'VE DONE HERE IS 588 00:24:02,040 --> 00:24:05,680 CREATED A MULTI-MODAL ANALYSIS 589 00:24:05,680 --> 00:24:07,800 THAT INTEGRATE THE 590 00:24:07,800 --> 00:24:10,320 CHARACTERISTICS ACROSS MULTIPLE 591 00:24:10,320 --> 00:24:12,320 MODALITIES INCLUDING MOLECULAR, 592 00:24:12,320 --> 00:24:14,040 INFORMATION, SPATIAL 593 00:24:14,040 --> 00:24:16,400 DISTRIBUTION, MORPHOLOGY, 594 00:24:16,400 --> 00:24:22,080 PHYSIOLOGY AND CONNECTIVITY AND 595 00:24:22,080 --> 00:24:24,840 AN EFFORT AND HELPED IDENTIFY 596 00:24:24,840 --> 00:24:28,120 PRINCIPLES OF DIVERSIFICATION OF 597 00:24:28,120 --> 00:24:31,040 BRAIN CELL TYPE AND SEE 598 00:24:31,040 --> 00:24:33,040 DIFFERENCES AND SETS THE STAGE 599 00:24:33,040 --> 00:24:35,000 FOR THE BRAIN CELL AND IN TERMS 600 00:24:35,000 --> 00:24:36,440 OF ORGANIZATION IT SHOWS IN THE 601 00:24:36,440 --> 00:24:37,880 RIGHT PLACE AND THE RIGHT TIME, 602 00:24:37,880 --> 00:24:40,280 THE POWER OF TEAM SCIENCE THERE 603 00:24:40,280 --> 00:24:42,800 WERE OVER 250 RESEARCHERS ON 604 00:24:42,800 --> 00:24:44,400 THIS PROJECT FROM OVER 45 605 00:24:44,400 --> 00:24:46,080 INSTITUTIONS AND THREE 606 00:24:46,080 --> 00:24:46,560 CONTINENTS. 607 00:24:46,560 --> 00:24:48,640 THIS IS A FIRST FOR NEUROSCIENCE 608 00:24:48,640 --> 00:24:48,880 RESEARCH. 609 00:24:48,880 --> 00:24:50,720 IT WAS A GREAT TEAM TO WORK 610 00:24:50,720 --> 00:24:50,920 WITH. 611 00:24:50,920 --> 00:24:53,280 I HAD THE PRIVILEGE OF BEING A 612 00:24:53,280 --> 00:24:57,040 P.I. ON THE PROJECT ON MY FORM 613 00:24:57,040 --> 00:24:59,080 ARE LIFE AND LOOKING FORWARD TO 614 00:24:59,080 --> 00:25:01,080 SEE WHAT THE NEW GROUP CAN DO 615 00:25:01,080 --> 00:25:02,680 MOVING FORWARD ON THE PROJECT. 616 00:25:02,680 --> 00:25:04,680 IN TERMS OF GAINING PRECISION 617 00:25:04,680 --> 00:25:06,600 ACCESS TO CELL TYPES, THERE'S 618 00:25:06,600 --> 00:25:08,800 BEEN A LOT OF PROGRESS GOING ON 619 00:25:08,800 --> 00:25:12,080 IN SEVERAL DIFFERENT FIELD. 620 00:25:12,080 --> 00:25:14,040 IN PARTICULAR IN THE ENGINEERING 621 00:25:14,040 --> 00:25:22,480 OF ADENO VIRUSES AND HERE'S DAT 622 00:25:22,480 --> 00:25:27,800 FROM A RECENT PAPER FROM KAL -- 623 00:25:27,800 --> 00:25:29,080 CAL TECH AND THEY USED 624 00:25:29,080 --> 00:25:31,800 DISTRICTED EVOLUTION TO IDENTIFY 625 00:25:31,800 --> 00:25:35,160 CAPSID MUTANT OR VARIANTS WITH 626 00:25:35,160 --> 00:25:38,080 VARIOUS PROPISMS FOR THE BRAIN 627 00:25:38,080 --> 00:25:41,440 AND A -- TROPISMS AVOIDING THE 628 00:25:41,440 --> 00:25:43,000 LIVER AND FOUND MULTIPLE CELL 629 00:25:43,000 --> 00:25:43,680 TYPES IN THE BRAIN AND 630 00:25:43,680 --> 00:25:46,080 IMPORTANTLY AVOIDING THE LIVER 631 00:25:46,080 --> 00:25:50,080 YOU CAN SEE THIS HERE THIS 632 00:25:50,080 --> 00:25:51,160 AVOIDANCE TO THE LIVER HERE AND 633 00:25:51,160 --> 00:25:54,240 IMPORTANTLY THE WORK IS NOT ONLY 634 00:25:54,240 --> 00:25:58,000 IN MICE BUT MARMOSETS AND WE'RE 635 00:25:58,000 --> 00:25:59,640 GETTING CLOSE TO REGIONS THAT 636 00:25:59,640 --> 00:26:01,640 ONE DAY COULD BE KEY FOR DRIVING 637 00:26:01,640 --> 00:26:03,320 GENE THERAPY APPROACHES IN THE 638 00:26:03,320 --> 00:26:03,880 HUMAN BRAIN. 639 00:26:03,880 --> 00:26:05,440 SO STAY TUNED. 640 00:26:05,440 --> 00:26:07,000 I THINK THIS IS A VERY EXCITING 641 00:26:07,000 --> 00:26:12,080 AREA AND OTHERS WORKING IN THIS 642 00:26:12,080 --> 00:26:14,960 AREA ARE WORKING TOWARDS SIMILAR 643 00:26:14,960 --> 00:26:15,920 GOALS AS WELL. 644 00:26:15,920 --> 00:26:17,680 LET ME CLOSE WITH A BRIEF 645 00:26:17,680 --> 00:26:20,440 SUMMARY OF THE BRAIN 646 00:26:20,440 --> 00:26:21,160 CONNECTIVITY PROJECT. 647 00:26:21,160 --> 00:26:23,680 BASED ON THE WORKSHOP WE HELD 648 00:26:23,680 --> 00:26:31,920 LAST YEAR IT WAS PRETTY CLEAR 649 00:26:31,920 --> 00:26:35,720 THE TASK WILL BE DAUNTING. 650 00:26:35,720 --> 00:26:38,560 I THINK THE UPSHOT WAS IT COULD 651 00:26:38,560 --> 00:26:41,200 BE FEASIBLE OR SHOULD BE 652 00:26:41,200 --> 00:26:43,720 FEASIBLE TO DO IN A MOUSE BRAIN 653 00:26:43,720 --> 00:26:47,280 AND PROBABLY FEASIBLE TO DO AT 654 00:26:47,280 --> 00:26:53,280 THE AX ON LEVEL IN A HUMAN BRAIN 655 00:26:53,280 --> 00:26:54,520 AND WE DON'T YET HAVE THE 656 00:26:54,520 --> 00:26:55,680 TECHNOLOGY TO DO THAT IN A 657 00:26:55,680 --> 00:26:56,360 TIMELY WAY. 658 00:26:56,360 --> 00:26:58,920 WE DECIDED TO SPLIT THIS EFFORT 659 00:26:58,920 --> 00:27:01,640 INTO TWO PHASES OVER THE NEXT 10 660 00:27:01,640 --> 00:27:03,880 YEARS AND THE GOALS FOR PHASE 1, 661 00:27:03,880 --> 00:27:05,640 THE FIRST FIVE YEARS IS TO 662 00:27:05,640 --> 00:27:07,360 ASSESS AND DEVELOP DIFFERENT 663 00:27:07,360 --> 00:27:08,600 APPROACHES THAT COULD WORK IF WE 664 00:27:08,600 --> 00:27:10,840 WERE TO SCALE THEM UP. 665 00:27:10,840 --> 00:27:13,440 AND ALONG THE WAY TO LEARN 666 00:27:13,440 --> 00:27:14,280 BIOLOGY ABOUT THAT. 667 00:27:14,280 --> 00:27:15,520 IN OTHER WORDS, WHAT WE'LL BE 668 00:27:15,520 --> 00:27:17,400 EXPECTING OF FOLKS THAT WE FUND 669 00:27:17,400 --> 00:27:19,280 IS TO DEVELOP NEW TECHNIQUES BUT 670 00:27:19,280 --> 00:27:21,120 TO HAVE SOME GOOD USE CASES SO 671 00:27:21,120 --> 00:27:23,440 WE CAN LEARN SOMETHING ABOUT 672 00:27:23,440 --> 00:27:25,440 RELEVANT NEURO CIRCUITS WHILE WE 673 00:27:25,440 --> 00:27:28,400 DEVELOP THE TECHNOLOGIES. 674 00:27:28,400 --> 00:27:30,080 AND THEN WE'LL EVALUATE 675 00:27:30,080 --> 00:27:32,680 STRATEGIC CHOICES FOR WHICH 676 00:27:32,680 --> 00:27:33,960 TECHNOLOGIES TO STAND UP IF ALL 677 00:27:33,960 --> 00:27:36,480 GOES WELL TO DEVELOP A PLAN FOR 678 00:27:36,480 --> 00:27:38,240 IMPLEMENTATION FOR THE SCALE UP 679 00:27:38,240 --> 00:27:39,640 PHASE WHICH IS PHASE 2. 680 00:27:39,640 --> 00:27:41,880 WE'RE ANTICIPATING A MIX OF 681 00:27:41,880 --> 00:27:42,720 DIFFERENT KINDS OF FUNDING 682 00:27:42,720 --> 00:27:44,880 OPPORTUNITY ANNOUNCEMENTS AND 683 00:27:44,880 --> 00:27:46,280 THEY'RE SUMMARIZED HERE. 684 00:27:46,280 --> 00:27:48,440 WE'LL STAND UP COMPREHENSIVE 685 00:27:48,440 --> 00:27:50,560 CENTERS THAT WILL BE AIMED AT 686 00:27:50,560 --> 00:27:51,840 CAPACITY BUILDING, TECHNOLOGY 687 00:27:51,840 --> 00:27:54,080 AND DEVELOPMENT AND 688 00:27:54,080 --> 00:27:55,800 DEMONSTRATION, DATA INTEGRATION, 689 00:27:55,800 --> 00:27:57,920 NEW KNOWLEDGE, IN OTHER WORDS, 690 00:27:57,920 --> 00:28:11,600 WE WANT TO LEARN TECHNIQUES AND 691 00:28:11,600 --> 00:28:14,080 THESE WILL BE FOCUSSED IN THE 692 00:28:14,080 --> 00:28:16,440 BIG BRAINS OR MOUSE BRAINS AT 693 00:28:16,440 --> 00:28:18,120 DIFFERENT LEVELS OF RESOLUTION. 694 00:28:18,120 --> 00:28:21,080 WE ALSO EXPECT TO FUND SMALLER 695 00:28:21,080 --> 00:28:23,240 PROJECTS AIMED AT DEVELOPING 696 00:28:23,240 --> 00:28:24,080 PERHAPS LESS WELL DEVELOPED 697 00:28:24,080 --> 00:28:26,800 TECHNOLOGIES THAT COULD ENHANCE 698 00:28:26,800 --> 00:28:31,320 THE EFFORT OVERALL AND BE 699 00:28:31,320 --> 00:28:33,880 INCORPORATED AND LOOKING AT LESS 700 00:28:33,880 --> 00:28:36,880 DEVELOPMENT AND POTENTIALLY RISK 701 00:28:36,880 --> 00:28:42,400 RISKIER TECHNIQUES WITH AN 702 00:28:42,400 --> 00:28:45,400 UPSTATE AND AN EFFORT FOR DATA 703 00:28:45,400 --> 00:28:46,840 COORDINATION AND EXPECT AN 704 00:28:46,840 --> 00:28:48,480 INTEGRATION ACROSS ALL THE 705 00:28:48,480 --> 00:28:48,720 GROUPS. 706 00:28:48,720 --> 00:28:50,920 WE WERE USING THE BICCN AS A 707 00:28:50,920 --> 00:28:53,520 MODEL FOR HOW TO SET UP AND 708 00:28:53,520 --> 00:28:54,360 COORDINATE EFFORTS ACROSS THE 709 00:28:54,360 --> 00:28:58,040 BOARD IN WHAT I EXPECT TO BE A 710 00:28:58,040 --> 00:29:00,880 HIGHLY COLLABORATIVE EFFORT TO 711 00:29:00,880 --> 00:29:02,000 ATTACK THIS VERY SIGNIFICANT AND 712 00:29:02,000 --> 00:29:06,000 DEEP PROBLEM. 713 00:29:06,000 --> 00:29:09,280 SO WITH THAT -- I DON'T KNOW IF 714 00:29:09,280 --> 00:29:10,720 WE HAVE TIME FOR QUESTIONS, 715 00:29:10,720 --> 00:29:14,000 SUSAN. 716 00:29:14,000 --> 00:29:17,360 I'LL STOP HERE. 717 00:29:17,360 --> 00:29:18,960 >> WE HAVE FOUR MINUTES AND WE 718 00:29:18,960 --> 00:29:20,080 CAN ALWAYS GO OVER BECAUSE WE 719 00:29:20,080 --> 00:29:21,960 HAVE A LONG BREAK IN BETWEEN 720 00:29:21,960 --> 00:29:26,800 OPEN AND CLOSED. 721 00:29:26,800 --> 00:29:51,080 ANY 722 00:29:51,080 --> 00:29:54,040 >> YOU HIGHLIGHT THE IMAGE ON 723 00:29:54,040 --> 00:29:57,080 THE BRAIN INVESTIGATORS' EFFORTS 724 00:29:57,080 --> 00:29:58,600 IN PUTTING THIS DIAGRAM 725 00:29:58,600 --> 00:29:59,320 TOGETHER. 726 00:29:59,320 --> 00:30:02,000 HAS HE BEEN ABLE TO USE THIS FOR 727 00:30:02,000 --> 00:30:04,080 NEUROSCIENCE IN GENERAL AND 728 00:30:04,080 --> 00:30:04,760 SCREENING GENERAL NEUROSCIENCE 729 00:30:04,760 --> 00:30:08,120 AND NEURONAL AND ALL THAT? 730 00:30:08,120 --> 00:30:10,440 IS IT DIFFERENT FOR THE BRAIN 731 00:30:10,440 --> 00:30:10,760 INVESTIGATOR? 732 00:30:10,760 --> 00:30:13,120 >> GREAT QUESTION. 733 00:30:13,120 --> 00:30:15,960 I BELIEVE MOHAMMAD PULLED INTO 734 00:30:15,960 --> 00:30:22,240 HIS DATABASE OVER 100 MILLION 735 00:30:22,240 --> 00:30:26,120 FROM PUB MED. 736 00:30:26,120 --> 00:30:28,280 ONE CAN LOOK AT THE LITERATURE 737 00:30:28,280 --> 00:30:30,800 AND LOOK TO SEE HOW FIELDS 738 00:30:30,800 --> 00:30:32,240 DEVELOP AND WHERE THE EDGES 739 00:30:32,240 --> 00:30:32,680 DEVELOP. 740 00:30:32,680 --> 00:30:38,080 YOU CAN SAY TO YOURSELF, WE DID 741 00:30:38,080 --> 00:30:42,920 IT AS KIND OF A TEST AND LOOK AT 742 00:30:42,920 --> 00:30:44,600 CERTAIN FIELD AND CERTAIN 743 00:30:44,600 --> 00:30:46,000 DISCOVERIES SPARK A NEW AREA OF 744 00:30:46,000 --> 00:30:50,040 INVESTIGATION AND YOU CAN SEE 745 00:30:50,040 --> 00:30:50,440 THO 746 00:30:50,440 --> 00:30:52,840 THOSE NODES AND EDGES DEVELOP 747 00:30:52,840 --> 00:30:54,520 OVER TIME AND WE THINK THIS IS A 748 00:30:54,520 --> 00:30:59,720 GREAT TOOL FOR LOOKING AT HOW 749 00:30:59,720 --> 00:31:01,360 RESEARCH AREAS HAVE DEVELOPED 750 00:31:01,360 --> 00:31:02,200 ACROSS THE BIOMEDICAL 751 00:31:02,200 --> 00:31:04,400 LITERATURE. 752 00:31:04,400 --> 00:31:06,880 NOW, THE ORIGINAL GOAL -- AND I 753 00:31:06,880 --> 00:31:09,080 THINK IT'S STILL AN ASPIRATIONAL 754 00:31:09,080 --> 00:31:12,480 GOAL, COULD WE BUILD A TOOL THAT 755 00:31:12,480 --> 00:31:17,680 WOULD ALLOW US TO PREDICT WHERE 756 00:31:17,680 --> 00:31:19,120 FIELDS ARE GOING. 757 00:31:19,120 --> 00:31:22,160 CAN WE USE THIS COMPUTER 758 00:31:22,160 --> 00:31:25,440 INTELLIGENCE TO HELP US THERE? 759 00:31:25,440 --> 00:31:27,640 SO FAR NOT WHY THE BUT WE SAW IT 760 00:31:27,640 --> 00:31:30,920 WAS A GOOD IDEA TO LOOK 761 00:31:30,920 --> 00:31:32,080 RETROSPECTIVELY FOR HOW FIELDS 762 00:31:32,080 --> 00:31:33,640 DEVELOPED AND PER YOUR LAST 763 00:31:33,640 --> 00:31:35,080 QUESTION, ONE THING WE'D LIKE TO 764 00:31:35,080 --> 00:31:37,760 KNOW IS WHETHER AND HOW BRAIN IS 765 00:31:37,760 --> 00:31:39,320 MAKING A DIFFERENCE BETWEEN THE 766 00:31:39,320 --> 00:31:42,040 OTHER 95% OF NIH-FUNDED 767 00:31:42,040 --> 00:31:44,080 NEUROSCIENCE RESEARCH SO WE CAN 768 00:31:44,080 --> 00:31:45,280 ASK CERTAIN QUESTIONS. 769 00:31:45,280 --> 00:31:48,800 ARE WE SEEING GREATER CONNECTS 770 00:31:48,800 --> 00:31:51,280 BETWEEN FIELD LOOKING AT 771 00:31:51,280 --> 00:31:52,560 BRAIN-FUNDED RESEARCH VERSUS 772 00:31:52,560 --> 00:31:52,760 OTHER. 773 00:31:52,760 --> 00:31:54,960 THAT'S A VERY QUICK EXAMPLE. 774 00:31:54,960 --> 00:31:56,400 THESE ARE THE KINDS OF THINGS WE 775 00:31:56,400 --> 00:31:58,040 WANT TO LOOK AT TO ASSESS WHAT 776 00:31:58,040 --> 00:32:00,040 OUR IMPACT IS TO MAKE 777 00:32:00,040 --> 00:32:03,680 ADJUSTMENTS TO PUSH HARDER IN 778 00:32:03,680 --> 00:32:04,920 AREAS THAT ARE WORKING AND AREAS 779 00:32:04,920 --> 00:32:06,920 THAT MAY BE LACKING. 780 00:32:06,920 --> 00:32:08,240 >> THANK YOU, JOHN. 781 00:32:08,240 --> 00:32:10,040 LOOK FORWARD TO SEEING IT. 782 00:32:10,040 --> 00:32:12,760 >> TED. 783 00:32:12,760 --> 00:32:13,440 >> HI. 784 00:32:13,440 --> 00:32:16,960 I'M JUST JOINING THE GROUP. 785 00:32:16,960 --> 00:32:17,200 THANKS. 786 00:32:17,200 --> 00:32:19,680 I HAVE -- FIRSTLY, I WANT TO 787 00:32:19,680 --> 00:32:21,000 SAY, JOHN, THANK YOU AND THIS 788 00:32:21,000 --> 00:32:24,680 GROUP AND SUSAN FOR PUSHING THE 789 00:32:24,680 --> 00:32:26,760 ENVELOPE FOR ALL OF US. 790 00:32:26,760 --> 00:32:28,280 IN OUR RESEARCH AREAS. 791 00:32:28,280 --> 00:32:32,000 THE REQUIREMENTS IN TERMS OF 792 00:32:32,000 --> 00:32:34,440 DIVERSITY AND THE EXPANSION YOU 793 00:32:34,440 --> 00:32:38,080 ALL HAVE DRIVEN HAS IMPACTED 794 00:32:38,080 --> 00:32:42,680 EVERYONE AT NIH AND ACROSS ALL 795 00:32:42,680 --> 00:32:47,560 INSTITUTIONS AND IT'S BEEN GREAT 796 00:32:47,560 --> 00:32:51,880 TO SEE HOW NIMBLE YOU CAN BE AND 797 00:32:51,880 --> 00:32:53,560 HAVING A GREAT IMPACT. 798 00:32:53,560 --> 00:32:55,880 I'VE BEEN STRUCK BY SOME OF MY 799 00:32:55,880 --> 00:32:58,400 COLLEAGUES WORKING ON 800 00:32:58,400 --> 00:33:00,840 CONNECTIONS TO METABOLISM -- 801 00:33:00,840 --> 00:33:02,040 EVEN CONNECTIONS TO CANCER OF 802 00:33:02,040 --> 00:33:05,320 NEURAL CONNECTIONS TO CANCER. 803 00:33:05,320 --> 00:33:08,360 STRUCK BY THE WORKSHOP AND 804 00:33:08,360 --> 00:33:10,040 REVIEW PAPER ON THE NEUROSCIENCE 805 00:33:10,040 --> 00:33:13,400 OF INTEROCEPTION. 806 00:33:13,400 --> 00:33:17,680 WE TALKED ABOUT THIS BUT THE 807 00:33:17,680 --> 00:33:19,040 NERVOUS SYSTEM IS MORE THAN THE 808 00:33:19,040 --> 00:33:30,080 BRAIN AND I THINK SOME OF THE 809 00:33:30,080 --> 00:33:32,000 PERIPHERAL AREAS CAN IMPACT THE 810 00:33:32,000 --> 00:33:35,200 WELL BEING OF SOME PATIENTS AND 811 00:33:35,200 --> 00:33:36,400 MAY EVEN BE THERAPEUTIC WITH 812 00:33:36,400 --> 00:33:36,880 SOME CANCERS. 813 00:33:36,880 --> 00:33:44,040 WHAT IS HAPPENING WITH THE 814 00:33:44,040 --> 00:33:45,880 PERIPHERAL SYSTEM AND SEEMS LIKE 815 00:33:45,880 --> 00:33:50,040 THERE'S IMPACT WE CAN MAKE IN 816 00:33:50,040 --> 00:33:54,480 THE PERIPHERY SO I WONDER ABOUT 817 00:33:54,480 --> 00:33:58,040 THAT. 818 00:33:58,040 --> 00:34:04,120 >> CLEARLY THE CENTRAL 819 00:34:04,120 --> 00:34:09,240 INFORMATION SYSTEM IS 820 00:34:09,240 --> 00:34:10,040 INTERACTING AND THERE'S QUITE A 821 00:34:10,040 --> 00:34:14,040 BIT GOING ON IN THE GUT-BRAIN 822 00:34:14,040 --> 00:34:15,600 AXIS AS WELL. 823 00:34:15,600 --> 00:34:18,080 SO WE ARE VERY KEEN TO EXPLORE 824 00:34:18,080 --> 00:34:20,320 THESE CONNECTIONS BOTH 825 00:34:20,320 --> 00:34:22,360 FIGURATIVELY AND LITERALLY 826 00:34:22,360 --> 00:34:22,720 SPEAKING. 827 00:34:22,720 --> 00:34:25,320 I THINK WHAT WE CAN DO IS COME 828 00:34:25,320 --> 00:34:27,200 AT IT FROM A CNS PERSPECTIVE AND 829 00:34:27,200 --> 00:34:29,480 MEET THE OTHER STUDIES SOMEWHERE 830 00:34:29,480 --> 00:34:33,880 ALONG THE WAY. 831 00:34:33,880 --> 00:34:35,360 SO WE DO HAVE PROGRAMS FOR 832 00:34:35,360 --> 00:34:37,160 EXAMPLE THE SPARK PROGRAM 833 00:34:37,160 --> 00:34:41,440 FOCUSSED ON THE PERIPHERAL 834 00:34:41,440 --> 00:34:50,880 SYSTEM AND THE NCCIH THE INTERO 835 00:34:50,880 --> 00:34:52,480 INFORMATION SYSTEM AND WE CAN 836 00:34:52,480 --> 00:34:54,880 FIND A WAY TO PARTNER AND 837 00:34:54,880 --> 00:34:55,600 PROMOTE COLLABORATIONS AND 838 00:34:55,600 --> 00:35:00,120 PROJECT LOOK AT THE NERVOUS 839 00:35:00,120 --> 00:35:00,880 SYSTEM MORE HOLISTICALLY BUT 840 00:35:00,880 --> 00:35:05,320 FROM DIFFERENT PERSPECTIVES. 841 00:35:05,320 --> 00:35:07,520 LOOK, THE MOTOR NEURON THE 842 00:35:07,520 --> 00:35:08,880 REASON TO EXIST IS TO MOVE 843 00:35:08,880 --> 00:35:10,280 MUSCLES AND TO SAY WE'RE NOT 844 00:35:10,280 --> 00:35:17,640 INTERESTED IN MUSCLES IS A 845 00:35:17,640 --> 00:35:22,240 LITTLE BIT SILLY TO MAXIMIZE THE 846 00:35:22,240 --> 00:35:22,560 POSSIBILITIES. 847 00:35:22,560 --> 00:35:35,600 >> THANKS, JOHN. 848 00:35:35,600 --> 00:35:37,720 >> MAYBE WE CAN MOVE ON TO HANK 849 00:35:37,720 --> 00:35:39,600 ON UPDATES AND ANYTHING ELSE YOU 850 00:35:39,600 --> 00:35:41,120 WANT TO INFORM US ABOUT. 851 00:35:41,120 --> 00:35:45,600 >> WELCOME TO THE NEW MEMBERS OF 852 00:35:45,600 --> 00:35:47,560 NEWG AND RETURNING MEMBERS. 853 00:35:47,560 --> 00:35:48,520 I THINK YOU'LL HEAR SOMETHING 854 00:35:48,520 --> 00:35:50,080 YOU HEARD BEFORE. 855 00:35:50,080 --> 00:35:52,480 SOME BACKGROUND ON THE 856 00:35:52,480 --> 00:35:53,920 NEUROETHICS WORKING GROUP FONDLY 857 00:35:53,920 --> 00:35:56,760 KNOWN AS THE NEWG FOR THE NEW 858 00:35:56,760 --> 00:35:58,080 MEMBERS. 859 00:35:58,080 --> 00:36:00,560 THE NEWG GOES BACK IN ONE FORM 860 00:36:00,560 --> 00:36:02,080 OR ANOTHER TO 2016. 861 00:36:02,080 --> 00:36:05,240 IT STARTED AFTER THE BRAIN 862 00:36:05,240 --> 00:36:05,520 INITIATIVE. 863 00:36:05,520 --> 00:36:10,440 WE HAVE ABOUT 10 MEMBERS, 864 00:36:10,440 --> 00:36:12,000 NEUROSCIENTISTS AND A COLLECTION 865 00:36:12,000 --> 00:36:16,200 OF PEOPLE I SAY ABOUT 10 BECAUSE 866 00:36:16,200 --> 00:36:18,480 JOHN IS IMPLEMENTING TERMS AND 867 00:36:18,480 --> 00:36:19,040 TERM LIMITS. 868 00:36:19,040 --> 00:36:26,480 PEOPLE ARE ROTATING ON AND OFF 869 00:36:26,480 --> 00:36:29,880 AND I DON'T KNOW THE EXACT COUNT 870 00:36:29,880 --> 00:36:30,080 TODAY. 871 00:36:30,080 --> 00:36:38,080 FOUR ARE MEMBERS OF THE MCWG AND 872 00:36:38,080 --> 00:36:46,080 ARE HERE TODAY AND WEARING TWO 873 00:36:46,080 --> 00:36:50,280 HATS. 874 00:36:50,280 --> 00:36:52,440 I WANT TO MENTION DR. TARA RAMOS 875 00:36:52,440 --> 00:36:56,080 WHO WAS THERE FROM THE BEGINNING 876 00:36:56,080 --> 00:36:57,880 AND COMMITMENT AND DEEP INTEREST 877 00:36:57,880 --> 00:36:59,880 IN NEURO ETHICS AND LEFT US NOT 878 00:36:59,880 --> 00:37:02,080 BECAUSE SHE WAS ROTATED OFF BUT 879 00:37:02,080 --> 00:37:06,080 TO TAKE A NEW POSITION WITH THE 880 00:37:06,080 --> 00:37:07,840 DATA FOUNDATION PURSUING 881 00:37:07,840 --> 00:37:11,480 INTEREST IN NEURO ETHICS AND WAS 882 00:37:11,480 --> 00:37:12,840 CRUCIAL TO THE FORMATION OF THE 883 00:37:12,840 --> 00:37:13,320 NEWG. 884 00:37:13,320 --> 00:37:16,200 WE GENERALLY MEET TWICE A YEAR. 885 00:37:16,200 --> 00:37:18,840 USUALLY THE DAY BEFORE THE MCWG 886 00:37:18,840 --> 00:37:20,960 MEETINGS IN JANUARY AND AUGUST 887 00:37:20,960 --> 00:37:28,480 AND WE PROVIDE INPUT BUT NEVER 888 00:37:28,480 --> 00:37:30,120 ADVICE TO THE BRAIN INITIATIVE 889 00:37:30,120 --> 00:37:32,880 SOMETIMES THROUGH THE MEETINGS 890 00:37:32,880 --> 00:37:34,480 AND SOMETIMES THROUGH THE 891 00:37:34,480 --> 00:37:38,080 MEETINGS AND PAY PLAN AND THE 892 00:37:38,080 --> 00:37:46,960 CON -- CONCEPTS AND PORTFOLIO 893 00:37:46,960 --> 00:37:48,000 ANALYSIS OF THE ENTIRE 894 00:37:48,000 --> 00:37:50,280 APPROXIMATE LOOKING FOR GRANTS 895 00:37:50,280 --> 00:37:52,480 THAT MAY HAVE NEUROETHICS 896 00:37:52,480 --> 00:37:53,240 ISSUES. 897 00:37:53,240 --> 00:37:55,520 WE PUBLISHED AT LEAST FOUR 898 00:37:55,520 --> 00:37:56,440 PUBLICATIONS HAVE COME OUT BASED 899 00:37:56,440 --> 00:37:59,560 ON NEWG ACTIVITIES. 900 00:37:59,560 --> 00:38:01,360 WE HELD SOME WORKSHOPS IN THE 901 00:38:01,360 --> 00:38:01,560 PAST. 902 00:38:01,560 --> 00:38:03,400 WE HAVE TWO PLANNED FOR LATER 903 00:38:03,400 --> 00:38:05,040 THIS YEAR. 904 00:38:05,040 --> 00:38:06,480 ONE ON POST-TRIAL 905 00:38:06,480 --> 00:38:07,680 RESPONSIBILITIES WHICH HAS BEEN 906 00:38:07,680 --> 00:38:10,040 A MAJOR ISSUE OF DISCUSSION 907 00:38:10,040 --> 00:38:11,040 THROUGHOUT THE HISTORY OF THE 908 00:38:11,040 --> 00:38:13,160 NEWG AND THE OTHER ON DATA 909 00:38:13,160 --> 00:38:15,120 SHARING WHICH HAS ALSO BEEN 910 00:38:15,120 --> 00:38:16,680 MAJOR WITH THE CHANGES IN THE 911 00:38:16,680 --> 00:38:18,760 NIH DATA SHARING POLICIES IS 912 00:38:18,760 --> 00:38:19,840 BECOMING EVEN MORE IMPORTANT. 913 00:38:19,840 --> 00:38:22,080 SO WE'LL BE DOING THOSE LATER 914 00:38:22,080 --> 00:38:25,600 THIS YEAR AND IT'S NOT CERTAIN 915 00:38:25,600 --> 00:38:27,520 BUT IT IS MY EXPECT THERE'LL 916 00:38:27,520 --> 00:38:29,360 PROBABLY BE PUBLICATIONS COMING 917 00:38:29,360 --> 00:38:32,480 OUT OF THAT. 918 00:38:32,480 --> 00:38:34,200 YESTERDAY'S MEETING WAS OF 919 00:38:34,200 --> 00:38:35,320 COURSE BY ZOOM. 920 00:38:35,320 --> 00:38:38,080 THE MAIN PART OF IT WAS A 921 00:38:38,080 --> 00:38:40,400 DISCUSSION OF ETHICAL CHALLENGES 922 00:38:40,400 --> 00:38:42,800 AND IMPLANTED NEURAL DEVICE 923 00:38:42,800 --> 00:38:44,080 RESEARCH WITH HUMAN 924 00:38:44,080 --> 00:38:44,400 PARTICIPANTS. 925 00:38:44,400 --> 00:38:48,960 THIS IS MODERATE MY CO-CHAIR 926 00:38:48,960 --> 00:38:53,280 FROM NIH AND FEATURED A COUPLE 927 00:38:53,280 --> 00:38:53,600 PRESENTATIONS. 928 00:38:53,600 --> 00:38:55,240 ONE FROM ASHLEY FINESINGER FROM 929 00:38:55,240 --> 00:38:58,000 UCLA AND ONE FROM THE UNIVERSITY 930 00:38:58,000 --> 00:39:00,400 OF WASHINGTON. 931 00:39:00,400 --> 00:39:03,040 ASHLEY'S WAS A PRESENTATION AND 932 00:39:03,040 --> 00:39:04,040 DISCUSSION AND PAPER CALLED 933 00:39:04,040 --> 00:39:05,800 INVESTIGATOR PERSPECTIVES ON 934 00:39:05,800 --> 00:39:07,280 ETHICAL COMMITMENTS, PRINCIPLES 935 00:39:07,280 --> 00:39:10,400 AND PRACTICES GUIDING 936 00:39:10,400 --> 00:39:12,280 INTRACRANIAL RESEARCH IN HUMANS. 937 00:39:12,280 --> 00:39:12,960 LONG TITLE. 938 00:39:12,960 --> 00:39:18,360 IT'S NOW I THINK OUT OF EMBARGO 939 00:39:18,360 --> 00:39:20,440 AND PUBLISHED IN NEURON AND HAD 940 00:39:20,440 --> 00:39:23,280 A NICE GENESIS. 941 00:39:23,280 --> 00:39:24,960 THE BRAIN INITIATIVE P.I.s 942 00:39:24,960 --> 00:39:26,240 WORKING IN THAT AREA GOT 943 00:39:26,240 --> 00:39:27,760 TOGETHER AS A RESEARCH ON HUMANS 944 00:39:27,760 --> 00:39:29,800 GROUP AND DECIDED TO START 945 00:39:29,800 --> 00:39:33,040 TALKING ABOUT THE ISSUES 946 00:39:33,040 --> 00:39:33,320 THEMSELVES. 947 00:39:33,320 --> 00:39:36,200 THERE WERE SOME INTERACTION WITH 948 00:39:36,200 --> 00:39:38,520 THE NEWG AND THIS PAPER CAME OUT 949 00:39:38,520 --> 00:39:40,040 AND PUT S OUT WHAT INVESTIGATORS 950 00:39:40,040 --> 00:39:42,760 SEE AS THE ETHICAL ISSUES WHICH 951 00:39:42,760 --> 00:39:44,280 WAS A REALLY INTERESTED MODEL 952 00:39:44,280 --> 00:39:47,520 GROUND UP FROM THE INVESTIGATORS 953 00:39:47,520 --> 00:39:48,760 COMING FORWARD DISCUSSION OF 954 00:39:48,760 --> 00:39:50,280 ETHICS AND I THINK THE NEWG WILL 955 00:39:50,280 --> 00:39:51,280 PROBABLY BE INTERESTED IN 956 00:39:51,280 --> 00:39:54,040 THINKING MORE ABOUT AS A WAY OF 957 00:39:54,040 --> 00:39:57,200 GOING FORWARD IN THE FUTURE. 958 00:39:57,200 --> 00:39:59,640 SARAH GERRING WORKED WITH 959 00:39:59,640 --> 00:40:03,840 IMPLANTS TALKING ETHICAL 960 00:40:03,840 --> 00:40:05,680 CONSIDERATIONS FOR ETHICAL 961 00:40:05,680 --> 00:40:06,520 CONSIDERATIONS FOR LONG-TERM 962 00:40:06,520 --> 00:40:07,520 STUDIES AND LEADING TO A 963 00:40:07,520 --> 00:40:09,400 DISCUSSION WITH ASHLEY AND SARAH 964 00:40:09,400 --> 00:40:14,120 AND WITH JAMES JOHNSON WHO IS A 965 00:40:14,120 --> 00:40:20,640 BCI BRAIN-COMPUTER INTERFACE 966 00:40:20,640 --> 00:40:28,440 RESEARCH PARTICIPANT. 967 00:40:28,440 --> 00:40:32,040 WAS A STUNNINGLY POWERFUL 968 00:40:32,040 --> 00:40:33,640 PARTICIPANT IN THE PANEL AS 969 00:40:33,640 --> 00:40:37,480 SOMEONE WHO HAS THE IMPLANT AND 970 00:40:37,480 --> 00:40:38,080 LIVING THROUGH THE RESEARCH. 971 00:40:38,080 --> 00:40:40,640 AND COMING OUT OF THAT, ONE OF 972 00:40:40,640 --> 00:40:43,680 THE THINGS WE NOW HAVE TO DO IS 973 00:40:43,680 --> 00:40:44,880 THE NEWG LEADERSHIP HAS TO 974 00:40:44,880 --> 00:40:46,080 FIGURE OUT WHERE TO GO FROM HERE 975 00:40:46,080 --> 00:40:49,680 BUT THINK THE ISSUES OF 976 00:40:49,680 --> 00:40:51,040 LONG-TERM HIGHLY INTERACTIVE 977 00:40:51,040 --> 00:40:54,040 STUDIES, INVASIVE STUDIES, 978 00:40:54,040 --> 00:40:57,080 FIGURING OUT EXACTLY WHAT THE 979 00:40:57,080 --> 00:41:00,040 UNIVERSE OF RELEVANT ISSUE 980 00:41:00,040 --> 00:41:01,520 STUDIES IS A BIT OF A TRICKY 981 00:41:01,520 --> 00:41:02,560 QUESTION BUT WE THINK THERE'S 982 00:41:02,560 --> 00:41:05,760 MORE ETHICAL DISCUSSIONS TO BE 983 00:41:05,760 --> 00:41:09,160 HAD AND MORE POTENTIALLY 984 00:41:09,160 --> 00:41:10,480 GUIDANCE OR INSIGHTS TO BE 985 00:41:10,480 --> 00:41:11,840 SHARED. 986 00:41:11,840 --> 00:41:13,680 THEN WE TALKED ABOUT IN A PART 987 00:41:13,680 --> 00:41:16,240 MODERATE ME WE TALKED ABOUT THE 988 00:41:16,240 --> 00:41:17,440 NEWG'S PAST, PRESENT AND FUTURE 989 00:41:17,440 --> 00:41:21,880 AND WHERE WE MIGHT BE HEADED. 990 00:41:21,880 --> 00:41:25,040 SO THAT IN APPROXIMATELY SIX 991 00:41:25,040 --> 00:41:27,560 MINUTES IS THE NEWG AND I'M GLAD 992 00:41:27,560 --> 00:41:29,680 TO SEE SUSAN SMILE AT ME KEEPING 993 00:41:29,680 --> 00:41:31,200 US ON TIME AND I'M HAPPY TO TRY 994 00:41:31,200 --> 00:41:43,600 TO ANSWER ANY OF YOUR QUESTIONS. 995 00:41:43,600 --> 00:41:45,880 I'M ALSO HAPPY TO ANSWER NO 996 00:41:45,880 --> 00:41:46,680 QUESTION. 997 00:41:46,680 --> 00:41:50,040 I'M REALLY GOOD AT ANSWERING NO 998 00:41:50,040 --> 00:41:50,280 QUESTIONS. 999 00:41:50,280 --> 00:41:54,040 >> ANY QUESTIONS? 1000 00:41:54,040 --> 00:41:56,560 >> IN THE ABSENCE OF QUESTIONS 1001 00:41:56,560 --> 00:42:00,840 I'LL SAY ONE MORE THING. 1002 00:42:00,840 --> 00:42:01,960 PARTICIPATING IN THE NEWG HAS AT 1003 00:42:01,960 --> 00:42:04,280 LEAST FOR ME AND I THINK ALL MY 1004 00:42:04,280 --> 00:42:08,160 FELLOW MEMBERS, BEEN A REALLY 1005 00:42:08,160 --> 00:42:10,880 FASCINATING OPPORTUNITY TO LOOK 1006 00:42:10,880 --> 00:42:13,680 AT THE TRULY INTERESTING ETHICS 1007 00:42:13,680 --> 00:42:16,960 ISSUES RAISED BY NEUROSCIENCE 1008 00:42:16,960 --> 00:42:24,200 AND I THINK I DON'T HAVE TO TELL 1009 00:42:24,200 --> 00:42:25,320 NEUROSCIENTISTS AND WHAT HUGE 1010 00:42:25,320 --> 00:42:27,080 ETHICAL ISSUES IT RAISES. 1011 00:42:27,080 --> 00:42:28,720 I'M REALLY PLEASED THE BRAIN 1012 00:42:28,720 --> 00:42:31,000 INITIATIVE HAS TAKEN THE 1013 00:42:31,000 --> 00:42:33,640 NEUROETHICS ISSUES SERIOUSLY AND 1014 00:42:33,640 --> 00:42:38,040 I KNOW JOHN AND I HAD REGULAR 1015 00:42:38,040 --> 00:42:38,680 LENGTHY DISCUSSIONS SOMETIMES WE 1016 00:42:38,680 --> 00:42:40,080 STICK STRICTLY TO BUSINESS AND 1017 00:42:40,080 --> 00:42:42,520 SOMETIME WE GO OFF ON BROADER 1018 00:42:42,520 --> 00:42:46,040 QUESTIONS OF NEUROETHICS. 1019 00:42:46,040 --> 00:42:48,840 I APPLAUD THE BRAIN INITIATIVE 1020 00:42:48,840 --> 00:42:52,240 AND NCWG FOR TAKING THESE 1021 00:42:52,240 --> 00:42:55,000 SERIOUSLY AND THEY'RE INFINITELY 1022 00:42:55,000 --> 00:42:56,040 FASCINATING TO GET A CHANCE TO 1023 00:42:56,040 --> 00:43:03,680 PLAY WITH AND I SEE A HAND. 1024 00:43:03,680 --> 00:43:06,320 I WAS GOING POSE YOU ASK A 1025 00:43:06,320 --> 00:43:07,600 QUESTION TO THE GROUP WHICH 1026 00:43:07,600 --> 00:43:08,520 ASKED YESTERDAY WHICH IS NAMELY 1027 00:43:08,520 --> 00:43:11,480 TO GET INPUT ON WHERE YOU THINK 1028 00:43:11,480 --> 00:43:16,520 THE ISSUES NEWG SHOULD BE 1029 00:43:16,520 --> 00:43:24,680 DEALING WITH WE SHOULD BE THINK 1030 00:43:24,680 --> 00:43:25,640 AND HELPING NEWG PLAN. 1031 00:43:25,640 --> 00:43:28,480 WE HAVE THE REPORT FROM THE 1032 00:43:28,480 --> 00:43:33,240 ADVISORY COMMITTEE TO THE 1033 00:43:33,240 --> 00:43:35,240 DIRECTOR ON NEUROETHICS AND 1034 00:43:35,240 --> 00:43:35,440 BRAIN. 1035 00:43:35,440 --> 00:43:37,280 THAT'S A GUIDANCE THAT'S OUT 1036 00:43:37,280 --> 00:43:42,080 THERE PIPPEN -- THERE. 1037 00:43:42,080 --> 00:43:47,240 I ENCOURAGE YOU TO TAKE A LOOK 1038 00:43:47,240 --> 00:43:53,480 AT AND GET INPUT TO PRIORITIZE 1039 00:43:53,480 --> 00:43:54,800 WHAT THE NEWG SHOULD BE TALKING 1040 00:43:54,800 --> 00:43:55,000 ABOUT. 1041 00:43:55,000 --> 00:43:58,320 >> IF I CAN ADD TO THAT, SILLY 1042 00:43:58,320 --> 00:44:01,280 FOR THE NEW MEMBERS JOINING US 1043 00:44:01,280 --> 00:44:06,840 HERE BUT ALSO AS A REMINDER FOR 1044 00:44:06,840 --> 00:44:08,480 ALL OF US WHO HAVE WORKED ON 1045 00:44:08,480 --> 00:44:09,400 THIS OVER THE LAST YEAR. 1046 00:44:09,400 --> 00:44:11,520 A LOT OF WHAT WE GOT DONE IN 1047 00:44:11,520 --> 00:44:15,080 BRAIN WE SAW THE ROLLOUT OF THE 1048 00:44:15,080 --> 00:44:16,400 PLAN FOR ENHANCED PERSPECTIVES 1049 00:44:16,400 --> 00:44:21,760 AND SAW THE ROLLOUT OF THE BRAIN 1050 00:44:21,760 --> 00:44:24,000 INITIATIVE CELL ATLAS NETWORK 1051 00:44:24,000 --> 00:44:26,080 AND FOR BOTH OF THESE LARGE 1052 00:44:26,080 --> 00:44:27,800 EFFORTS, WE HAD TO DIG DOWN DEEP 1053 00:44:27,800 --> 00:44:31,000 AND THINK LONG AND HARD ABOUT 1054 00:44:31,000 --> 00:44:32,680 WHO IS DOING THE EXPERIMENTING 1055 00:44:32,680 --> 00:44:34,080 AND WHO IS DOING THE DECIDING 1056 00:44:34,080 --> 00:44:35,760 AND THEREFORE WHO IS GOING TO BE 1057 00:44:35,760 --> 00:44:38,160 BENEFIT FROM THE RICHES THAT WE 1058 00:44:38,160 --> 00:44:39,680 INTEND TO CREATE HERE. 1059 00:44:39,680 --> 00:44:44,680 AND THESE REALLY CAME OUT OF 1060 00:44:44,680 --> 00:44:47,200 DISCUSSIONS NOT JUST AT MCWG AND 1061 00:44:47,200 --> 00:44:50,040 NEWG BUT JOINT DISCUSSIONS. 1062 00:44:50,040 --> 00:44:51,480 I REALLY THINK IT SPEAKS TO THE 1063 00:44:51,480 --> 00:44:54,600 POWER OF COLLABORATION OF 1064 00:44:54,600 --> 00:44:56,040 BRINGING DIVERSE PERSPECTIVES TO 1065 00:44:56,040 --> 00:44:58,040 BEAR ON EXAMINING AND THEN 1066 00:44:58,040 --> 00:45:02,000 FINDING A WAY TO ADDRESS KEY 1067 00:45:02,000 --> 00:45:03,800 ISSUES OF OUR TIME. 1068 00:45:03,800 --> 00:45:13,080 CLEARLY WE HAVE A WORKFORCE AND 1069 00:45:13,080 --> 00:45:15,080 DIVERSITY ISSUE AND I THINK 1070 00:45:15,080 --> 00:45:16,480 BRAIN IS LEADING A WAY TO A 1071 00:45:16,480 --> 00:45:19,440 BETTER PLACE ON THIS. 1072 00:45:19,440 --> 00:45:20,920 IN TERMS OF THE CELL CENSUS 1073 00:45:20,920 --> 00:45:22,000 PROJECT WE THOUGHT WHO IS IT WE 1074 00:45:22,000 --> 00:45:25,040 NEED TO STUDY TO GET THE BEST 1075 00:45:25,040 --> 00:45:28,960 INFORMATION OUT IN ORDER TO A, 1076 00:45:28,960 --> 00:45:34,080 UNDERSTOOD HOW THE HUMAN BRAIN 1077 00:45:34,080 --> 00:45:35,760 IS PUT TOGETHER AND TREAT AS 1078 00:45:35,760 --> 00:45:37,280 MANY PEOPLE AS POSSIBLE AND HAD 1079 00:45:37,280 --> 00:45:39,600 WE NOT HAD AN INTENSE DISCUSSION 1080 00:45:39,600 --> 00:45:42,080 ABOUT EQUITY AND INCLUSION, I'M 1081 00:45:42,080 --> 00:45:43,640 NOT SURE WE WOULD HAVE COME TO 1082 00:45:43,640 --> 00:45:45,280 THIS PLACE WE CAME TO. 1083 00:45:45,280 --> 00:45:48,240 ALL LOOKING FORWARD TO A WORK IN 1084 00:45:48,240 --> 00:45:51,840 PROGRESS BUT SPEAKS TO THE 1085 00:45:51,840 --> 00:45:54,360 INCREDIBLE POWER OF POWER OF 1086 00:45:54,360 --> 00:45:57,200 COLLABORATION AND LAST YEAR WE 1087 00:45:57,200 --> 00:45:58,560 HAD A JOINT SESSION BETWEEN THE 1088 00:45:58,560 --> 00:46:00,880 TWO GROUPS AND NOT TO OVER 1089 00:46:00,880 --> 00:46:02,200 BURDEN EVERYONE HERE BUT AS 1090 00:46:02,200 --> 00:46:03,760 WALTER ASKED, WE'D LIKE YOUR 1091 00:46:03,760 --> 00:46:06,200 INPUT ON AREAS YOU FEEL WE 1092 00:46:06,200 --> 00:46:08,120 SHOULD BE PAYING ATTENTION TO 1093 00:46:08,120 --> 00:46:09,680 BEYOND THE SPECIFIC EXPERIMENTS 1094 00:46:09,680 --> 00:46:11,840 THAT WE'RE FUNDING. 1095 00:46:11,840 --> 00:46:14,400 >> THIS YEAR MARKS, I THINK, 1096 00:46:14,400 --> 00:46:18,040 MANY PEOPLE IN THE FIELD THINK 1097 00:46:18,040 --> 00:46:25,600 THE 20th ANNIVERSARY FROM A 1098 00:46:25,600 --> 00:46:28,840 NEURO ETHICS MEETING AND HASN'T 1099 00:46:28,840 --> 00:46:32,600 BEEN JUST A TOY FOR PHILOSOPHERS 1100 00:46:32,600 --> 00:46:35,440 AND LAWYERS AND IT'S HAD BUY IN 1101 00:46:35,440 --> 00:46:38,320 AND PARTICIPATION FROM NEURO 1102 00:46:38,320 --> 00:46:40,640 SCIENTISTS AND CLINICIANS AND WE 1103 00:46:40,640 --> 00:46:44,360 SEE IT ON THE CURRENT NEWG AND 1104 00:46:44,360 --> 00:46:48,840 EVER IN THE MCWG IS ALMOST BY 1105 00:46:48,840 --> 00:46:49,560 DEFINITION QUALIFIED TO OFFER 1106 00:46:49,560 --> 00:46:52,840 USING THOUGHTS, NOT ADVICE, BUT 1107 00:46:52,840 --> 00:46:56,080 USEFUL THOUGHTS AND INPUTS ON 1108 00:46:56,080 --> 00:46:59,880 THE NEURO ETHICS ISSUES AND IT'S 1109 00:46:59,880 --> 00:47:03,400 CRUCIAL TO GO FORWARD THERE BE A 1110 00:47:03,400 --> 00:47:06,080 CONTINUING DIALOGUE BETWEEN THE 1111 00:47:06,080 --> 00:47:08,040 SCIENTISTS, CLINICIANS AND 1112 00:47:08,040 --> 00:47:11,600 ETHICS PEOPLE AND PARTICIPANTS 1113 00:47:11,600 --> 00:47:15,360 ALL GOING TO STRONGLY SECONDING 1114 00:47:15,360 --> 00:47:16,160 WALTER'S SUGGESTION AND WOULD 1115 00:47:16,160 --> 00:47:17,320 LOVE TO HEAR THOUGHTS ON WHAT 1116 00:47:17,320 --> 00:47:24,120 THE NEWG SHOULD BE DOING. 1117 00:47:24,120 --> 00:47:25,280 SUSAN, I THINK THERE'S 30 1118 00:47:25,280 --> 00:47:27,560 SECONDS LEFT. 1119 00:47:27,560 --> 00:47:29,640 >> WE HAVE A BREAK SCHEDULED NOW 1120 00:47:29,640 --> 00:47:31,080 BEFORE THE CONCEPT TO FEEL FREE 1121 00:47:31,080 --> 00:47:32,680 TO CONTINUE TO THINK ABOUT THIS 1122 00:47:32,680 --> 00:47:37,240 AND PROVIDE INPUT TO JOHN AND TO 1123 00:47:37,240 --> 00:47:39,080 HANK AND I THINK THERE'LL BE 1124 00:47:39,080 --> 00:47:40,600 OPPORTUNITIES TO HEAR YOU FROM 1125 00:47:40,600 --> 00:47:42,080 AND WE THINK WE WILL. 1126 00:47:42,080 --> 00:47:42,200 1127 00:47:44,400 --> 00:47:47,880 OKAY, THEN, I WILL -- NOT SEEING 1128 00:47:47,880 --> 00:47:50,080 HANDS I'LL CALL THE BREAK AND 1129 00:47:50,080 --> 00:47:54,080 WE'LL BE BACK AT 1:00 FOR THE 1130 00:47:54,080 --> 00:48:00,280 CONCEPT PRESENTATION BY DR. SHUM 1131 00:48:00,280 --> 00:48:01,240 SHUMIN WANG ON NON-INVASIST 1132 00:48:01,240 --> 00:48:02,440 BRAIN FUNCTIONING IMAGING 1133 00:48:02,440 --> 00:48:03,760 TECHNOLOGIES. 1134 00:48:03,760 --> 00:48:07,840 THANK YOU BOTH. 1135 00:48:07,840 --> 00:48:10,400 MY NAME IS SHUMIN WANG PROGRAM 1136 00:48:10,400 --> 00:48:14,600 DIRECTOR AT THE NATIONAL 1137 00:48:14,600 --> 00:48:18,240 INSTITUTE OF BIOENGINEERING AND 1138 00:48:18,240 --> 00:48:21,920 I'M GOING PRESENT NON-INVASIVE 1139 00:48:21,920 --> 00:48:23,960 BRAIN FUNCTIONAL IMAGING 1140 00:48:23,960 --> 00:48:25,400 TECHNOLOGY CONCEPT. 1141 00:48:25,400 --> 00:48:27,920 BECAUSE IT'S IMPLEMENTATION 1142 00:48:27,920 --> 00:48:30,680 MANAGED BY IBIB I HAVE ALSO 1143 00:48:30,680 --> 00:48:32,320 PRESENTED A WEEK AGO AT A 1144 00:48:32,320 --> 00:48:34,760 COUNCIL MEETING AND RECEIVED A 1145 00:48:34,760 --> 00:48:36,640 HIGHLY VALUABLE COMMENTS. 1146 00:48:36,640 --> 00:48:40,440 SO I'M GOING PRESENT THE CONCEPT 1147 00:48:40,440 --> 00:48:43,800 HERE AGAIN TODAY AND BRING UP 1148 00:48:43,800 --> 00:48:46,760 THOSE COMMENTS DURING MY 1149 00:48:46,760 --> 00:48:48,320 PRESENTATION AND THEN WELCOME 1150 00:48:48,320 --> 00:48:52,280 DISCUSSION ON THOSE POINTS. 1151 00:48:52,280 --> 00:48:54,120 FIRST OF ALL, I WANT TO GIVE A 1152 00:48:54,120 --> 00:48:56,840 BIG SHOUT OUT TO OUR TASK FORCE 1153 00:48:56,840 --> 00:49:00,520 MEMBERS WHO COME FROM DIFFERENT 1154 00:49:00,520 --> 00:49:02,160 PARTICIPATING I.C.s OF THE 1155 00:49:02,160 --> 00:49:02,560 INITIATIVE. 1156 00:49:02,560 --> 00:49:04,480 WE HAVE MULTIPLE MEETINGS AND 1157 00:49:04,480 --> 00:49:07,800 PRESENTED THIS CONCEPT AT 1158 00:49:07,800 --> 00:49:10,880 DIFFERENT LEVELS WITHIN NIH. 1159 00:49:10,880 --> 00:49:19,520 THIS IS TRULY A TEAM WORK. 1160 00:49:19,520 --> 00:49:22,480 SO THIS CONCEPT IS SUPPOSED TO 1161 00:49:22,480 --> 00:49:23,880 MAKE A CONTRIBUTION TO THE 1162 00:49:23,880 --> 00:49:26,320 FOLLOWING THREE PRIORITY AREAS 1163 00:49:26,320 --> 00:49:31,080 IN THE BRAIN 2025 REPORT. 1164 00:49:31,080 --> 00:49:34,040 AREA TWO MATCH WORKFORCE SKILLS 1165 00:49:34,040 --> 00:49:37,560 FOR DIAGRAMS INTRODUCE FROM 1166 00:49:37,560 --> 00:49:39,000 SYNAPSIS TO THE WHOLE BRAIN. 1167 00:49:39,000 --> 00:49:41,520 FOR IMAGING WE ARE PRIMARY 1168 00:49:41,520 --> 00:49:46,440 INTERESTED IN MICROSCOPY 1169 00:49:46,440 --> 00:49:47,600 RESOLUTION AND MESO SCALE DOWN 1170 00:49:47,600 --> 00:49:50,160 TO 100 MICRONS AND HOPEFULLY 1171 00:49:50,160 --> 00:49:51,920 DURING THE SECOND PHASE OF OUR 1172 00:49:51,920 --> 00:49:58,960 INITIATIVE WE CAN MAKE A SPATIAL 1173 00:49:58,960 --> 00:50:00,240 SKILL AND THE BRAIN ACTION STO 1174 00:50:00,240 --> 00:50:02,560 PRODUCE THE DYNAMIC PICTURE OF 1175 00:50:02,560 --> 00:50:05,560 THE FUNCTIONING BRAIN BY 1176 00:50:05,560 --> 00:50:07,360 DEVELOPING AND APPLYING METHOD 1177 00:50:07,360 --> 00:50:10,280 FOR LARGE-SCALE MONITORING OF 1178 00:50:10,280 --> 00:50:13,360 NEURAL ACTIVITY AND TALKING 1179 00:50:13,360 --> 00:50:18,560 ABOUT DYNAMIC RANGE SPANS THREE 1180 00:50:18,560 --> 00:50:21,760 OTHER MAGNITUDES TO HUMAN 1181 00:50:21,760 --> 00:50:25,600 DYNAMICS AND ALL THE WAY TO A 1182 00:50:25,600 --> 00:50:31,920 TENTHS OF A SECOND FOR MOLECULAR 1183 00:50:31,920 --> 00:50:34,280 IMAGING SO THE THREE OTHER FOR 1184 00:50:34,280 --> 00:50:38,160 THE RANGE IS ALSO HUGE. 1185 00:50:38,160 --> 00:50:39,960 FINALLY THE PRIORITY AREA NUMBER 1186 00:50:39,960 --> 00:50:44,960 6 IS THE HUMAN NEUROSCIENCE TO 1187 00:50:44,960 --> 00:50:46,920 DEVELOP METHODOLOGIES FOR 1188 00:50:46,920 --> 00:50:49,760 HEALTHY HUMAN SUBJECT. 1189 00:50:49,760 --> 00:50:51,680 IN 2019 THE BRAIN INITIATIVE 1190 00:50:51,680 --> 00:50:55,360 ORGANIZED A WORKING GROUP 2.0 TO 1191 00:50:55,360 --> 00:50:58,440 EVALUATE THE FIRST PHASE OF OUR 1192 00:50:58,440 --> 00:50:59,920 INITIATIVE AND ALSO MADE SOME 1193 00:50:59,920 --> 00:51:01,360 RECOMMENDATIONS FOR THE NEXT 1194 00:51:01,360 --> 00:51:01,680 PHASE. 1195 00:51:01,680 --> 00:51:03,320 HERE ARE SOME EXAMPLES RELATED 1196 00:51:03,320 --> 00:51:07,080 TO NON-INVASIVE IMAGING. 1197 00:51:07,080 --> 00:51:10,120 THE NUMBER 3 IN PRIORITY AREA 2 1198 00:51:10,120 --> 00:51:15,960 IS TO DEVELOP HIGH RESOLUTION 1199 00:51:15,960 --> 00:51:17,600 FMRI WITH THE RESOLUTION AND 1200 00:51:17,600 --> 00:51:18,960 CONSIDERED CURRENTLY THE BEST AS 1201 00:51:18,960 --> 00:51:20,600 WE SPEAK. 1202 00:51:20,600 --> 00:51:25,520 THE RESOLUTION OF FMR IS 0.01 1203 00:51:25,520 --> 00:51:28,560 CUBIC MILLIMETER SO IT 1204 00:51:28,560 --> 00:51:30,880 REPRESENTS ORDER OF MAGNITUDE 1205 00:51:30,880 --> 00:51:35,080 WITH IMPROVEMENT WHICH IS HUGE. 1206 00:51:35,080 --> 00:51:39,920 SHORT TERM GOAL NUMBER 4 IN AREA 1207 00:51:39,920 --> 00:51:43,920 3 IS TO DEVELOP TOOLS FOR 1208 00:51:43,920 --> 00:51:46,560 REALISTIC BEHAVIOR AND THINKING 1209 00:51:46,560 --> 00:51:48,240 OF PEOPLE WALKING ON THE STREET 1210 00:51:48,240 --> 00:51:52,480 OR TALKING TO EACH OTHER. 1211 00:51:52,480 --> 00:51:53,120 CONVENTIONAL TECHNOLOGIES SUCH 1212 00:51:53,120 --> 00:51:55,920 AS MRI OR PET ARE DESIGNED FOR 1213 00:51:55,920 --> 00:52:00,360 IMAGING STATIONARY SUBSET OF 1214 00:52:00,360 --> 00:52:00,640 PATIENTS. 1215 00:52:00,640 --> 00:52:03,400 WE THOUGHT IT IT'S IMAGINABLE TO 1216 00:52:03,400 --> 00:52:07,240 SOMEONE WALKING FREELY MOVING 1217 00:52:07,240 --> 00:52:10,240 FREELY AND AS YOU CAN SEE THE 1218 00:52:10,240 --> 00:52:11,080 CHALLENGE IS HUGE. 1219 00:52:11,080 --> 00:52:17,360 THE QUESTION IS CAN WE ACTUALLY 1220 00:52:17,360 --> 00:52:20,560 ACHIEVE THOSE GOALS. 1221 00:52:20,560 --> 00:52:23,240 THIS CONCEPT HAS SOME PRECEDING 1222 00:52:23,240 --> 00:52:23,960 ONES. 1223 00:52:23,960 --> 00:52:29,800 WE HAVE RO1 PROOF OF CONCEPT RFA 1224 00:52:29,800 --> 00:52:33,760 AND ALSO A U1 DURING THE FIRST 1225 00:52:33,760 --> 00:52:37,760 PHASE OF THE BRAIN INITIATIVE. 1226 00:52:37,760 --> 00:52:38,560 IN ORDER TO EVALUATE WHERE WE 1227 00:52:38,560 --> 00:52:42,760 ARE NOW AND WHERE WE CAN GO IN 1228 00:52:42,760 --> 00:52:44,960 10 YEARS WE HAD A WORKSHOP AND 1229 00:52:44,960 --> 00:52:47,480 THE FIRST WAS A DISSEMINATION 1230 00:52:47,480 --> 00:52:49,800 WORKSHOP IN FEBRUARY FOCUSSING 1231 00:52:49,800 --> 00:52:51,880 ON EVALUATING THE SUCCESS AND 1232 00:52:51,880 --> 00:52:52,560 INVESTMENT THE BRAIN INITIATIVE 1233 00:52:52,560 --> 00:52:55,720 MADE TO NON-INVASIVE 1234 00:52:55,720 --> 00:52:57,840 TECHNOLOGIES DURING THE FIRST 1235 00:52:57,840 --> 00:52:58,040 PHASE. 1236 00:52:58,040 --> 00:53:00,040 THE SECOND IS A TRANSFORMATIVE 1237 00:53:00,040 --> 00:53:01,760 WORKSHOP WHICH FOCUSES ON 1238 00:53:01,760 --> 00:53:03,600 POSSIBLE NEW TECHNOLOGIES THAT 1239 00:53:03,600 --> 00:53:07,920 COULD BE DEVELOPED IN THE NEXT 1240 00:53:07,920 --> 00:53:11,520 FIVE TO 10 YEARS AND SOLICITED 1241 00:53:11,520 --> 00:53:13,960 PUBLIC INPUT BASED ON THE 1242 00:53:13,960 --> 00:53:15,720 OUTCOMES OF THE TWO WORK SHOPS 1243 00:53:15,720 --> 00:53:18,800 AND RFI HERE. 1244 00:53:18,800 --> 00:53:22,240 FIRST OF ALL, ACCOMPANYING NEW 1245 00:53:22,240 --> 00:53:27,360 MODALITIES TO BROADEN THE 1246 00:53:27,360 --> 00:53:31,960 APPLICABILITY AND THIS IS 1247 00:53:31,960 --> 00:53:34,120 CURRENTLY BEING INVOLVED BY A 1248 00:53:34,120 --> 00:53:37,120 RESEARCH GROUP WOULD ENABLE 1249 00:53:37,120 --> 00:53:39,960 TAKING CORTICO HUMAN DYNAMICS 1250 00:53:39,960 --> 00:53:40,800 INFORMATION FROM SUBJECT MOVING 1251 00:53:40,800 --> 00:53:43,160 FREELY IN A LAB OR ON THE STREET 1252 00:53:43,160 --> 00:53:45,160 OR TALKING TO ANOTHER PERSON. 1253 00:53:45,160 --> 00:53:49,440 SO THIS CAPABILITY CANNOT EXIST 1254 00:53:49,440 --> 00:53:50,640 PRIOR TO THE BRAIN INITIATIVE. 1255 00:53:50,640 --> 00:53:57,120 FOR EXISTING MODALITIES SUCH AS 1256 00:53:57,120 --> 00:54:00,360 MEG, PET AND F MRI WE ASSIST THE 1257 00:54:00,360 --> 00:54:05,920 TECHNOLOGY AS YOU CAN SEE FROM 1258 00:54:05,920 --> 00:54:10,040 THE LOWER LEFT CORNER THIS IS A 1259 00:54:10,040 --> 00:54:15,920 HIGH RADIO FREQUENCY RECEIVER TO 1260 00:54:15,920 --> 00:54:21,280 ENABLE THE PRECISION OF 400 1261 00:54:21,280 --> 00:54:22,600 MICRON LEVEL SO IMPROVEMENT IS 1262 00:54:22,600 --> 00:54:24,160 POSSIBLE IN THE NEXT YEAR OR 1263 00:54:24,160 --> 00:54:25,360 TWO. 1264 00:54:25,360 --> 00:54:27,600 SO MOST THE PROJECTS MOVES TO 1265 00:54:27,600 --> 00:54:30,560 THIS YEAR AND WE DO EXPECT TO 1266 00:54:30,560 --> 00:54:31,960 DELIVER PRODUCT. 1267 00:54:31,960 --> 00:54:35,400 SO BECAUSE OF THIS MUCH IMPROVED 1268 00:54:35,400 --> 00:54:37,240 SENSITIVITY, WE COULD GET MUCH 1269 00:54:37,240 --> 00:54:39,880 BETTER RESOLUTION DOWN TO THE 1270 00:54:39,880 --> 00:54:43,320 MESO SCALE LEVEL BY USING THESE 1271 00:54:43,320 --> 00:54:45,440 DEVICES WHICH WOULD NOT BE DONE 1272 00:54:45,440 --> 00:54:46,920 PRIOR TO THE BRAIN INITIATIVE. 1273 00:54:46,920 --> 00:54:48,160 DESPITE THE ACHIEVEMENT WE'RE 1274 00:54:48,160 --> 00:54:52,560 NOT NEAR THE END OF THE ROPE. 1275 00:54:52,560 --> 00:54:54,880 WE HAVE OPPORTUNITIES THAT EXIST 1276 00:54:54,880 --> 00:55:02,560 AND LIST ON THE NEXT SLIDE. 1277 00:55:02,560 --> 00:55:03,960 HERE'S ALTERNATIVES WE 1278 00:55:03,960 --> 00:55:06,120 SUMMARIZED I WANT TO EMPHASIZE 1279 00:55:06,120 --> 00:55:07,200 THE TOP TWO. 1280 00:55:07,200 --> 00:55:09,760 THE FIRST ONE IS KNOX 1281 00:55:09,760 --> 00:55:12,960 INTEGRATIVE SYSTEM TO ASSESS 1282 00:55:12,960 --> 00:55:15,960 MULTIPLE SCALES TALKING ABOUT 1283 00:55:15,960 --> 00:55:18,240 MESO SCALE TO MACRO SKILL. 1284 00:55:18,240 --> 00:55:22,560 AND THE ASPECT OF BRAIN 1285 00:55:22,560 --> 00:55:28,560 FUNCTIONAL CONNECTIVITY SO USING 1286 00:55:28,560 --> 00:55:32,560 INDIVIDUAL MODALITIES WITH 1287 00:55:32,560 --> 00:55:39,960 DYNAMICS AND MOLECULAR IMAGING 1288 00:55:39,960 --> 00:55:41,960 HAS SEEN IMPROVEMENT AND THE 1289 00:55:41,960 --> 00:55:43,560 INTEGRATED SYSTEM CAN PROVIDE A 1290 00:55:43,560 --> 00:55:47,040 COMPLETE AND COMPLIMENTARY 1291 00:55:47,040 --> 00:55:50,160 PICTURE OF ACTIVITIES STILL 1292 00:55:50,160 --> 00:55:50,840 LACKING. 1293 00:55:50,840 --> 00:55:54,360 WE RECOGNIZE THIS IS A GREAT 1294 00:55:54,360 --> 00:55:58,280 OPPORTUNITY ESPECIALLY FOR 1295 00:55:58,280 --> 00:55:59,600 DEVELOPMENT AND GONE TO A 1296 00:55:59,600 --> 00:56:00,000 SPECIAL EMPHASIS. 1297 00:56:00,000 --> 00:56:03,680 THE SECOND BULLET IS ON MACHINE 1298 00:56:03,680 --> 00:56:06,800 LEARNING AND THE TECHNIQUES. 1299 00:56:06,800 --> 00:56:09,960 BOTH ARE COMPLETION BASED. 1300 00:56:09,960 --> 00:56:12,960 THIS IS SORT OF INDEPENDENT FROM 1301 00:56:12,960 --> 00:56:14,560 HARDWARE DEVELOPMENT. 1302 00:56:14,560 --> 00:56:17,040 SO WE HAVE A GREAT EXAMPLES IN 1303 00:56:17,040 --> 00:56:20,920 THE PORTFOLIO THAT DEMONSTRATE 1304 00:56:20,920 --> 00:56:23,320 SUCH MEASURES CAN IMPROVE THE 1305 00:56:23,320 --> 00:56:25,360 PERFORMANCE OF VERY COSTLY 1306 00:56:25,360 --> 00:56:26,040 EFFECTIVE MANNER. 1307 00:56:26,040 --> 00:56:29,800 FOR INSTANCE, ONE OF THE AWARDEE 1308 00:56:29,800 --> 00:56:31,440 DEVELOPED THE DATA-DRIVEN 1309 00:56:31,440 --> 00:56:35,920 TECHNOLOGY AND APPLIED IT TO 1310 00:56:35,920 --> 00:56:38,520 PROCESS HUMAN CONNECTOME PROJECT 1311 00:56:38,520 --> 00:56:38,840 DATA. 1312 00:56:38,840 --> 00:56:42,720 AND HE WAS ABLE TO IMPROVE 1313 00:56:42,720 --> 00:56:45,600 SPATIAL RESOLUTION FOR DIFFUSION 1314 00:56:45,600 --> 00:56:49,280 IMAGING FROM 1.5 METER CUBIC TO 1315 00:56:49,280 --> 00:56:55,920 0.375 METER CUBIC REPRESENTING 1316 00:56:55,920 --> 00:56:58,040 THE SENSITIVITY IMPROVEMENT 1317 00:56:58,040 --> 00:57:00,320 WITHOUT RE-WRITING THE ENTIRE 1318 00:57:00,320 --> 00:57:01,040 EXPERIMENT. 1319 00:57:01,040 --> 00:57:03,520 WE BELIEVE BY EMPHASIZING THIS 1320 00:57:03,520 --> 00:57:04,160 COMPETITION-BASED TECHNOLOGY 1321 00:57:04,160 --> 00:57:07,280 THIS COST-EFFECTIVENESS COULD 1322 00:57:07,280 --> 00:57:08,920 PROPAGATE VERY SOON TO OTHER 1323 00:57:08,920 --> 00:57:11,480 AREAS OF NON-INVASIVE IMAGING 1324 00:57:11,480 --> 00:57:15,960 AND MAKE A BIGGER IMPACT TO THE 1325 00:57:15,960 --> 00:57:23,960 COMMUNITY. 1326 00:57:23,960 --> 00:57:26,160 SO ENCOURAGED BY THE NEW 1327 00:57:26,160 --> 00:57:29,920 OPPORTUNITIES WE PROPOSED THE 1328 00:57:29,920 --> 00:57:30,160 CONCEPT. 1329 00:57:30,160 --> 00:57:34,520 THE CONCEPT IS THREEFOLD. 1330 00:57:34,520 --> 00:57:36,400 FIRST IS TO CONTINUE THE 1331 00:57:36,400 --> 00:57:38,560 MOMENTUM WITH THE INTEGRATIVE 1332 00:57:38,560 --> 00:57:39,880 APPROACH FOR BRIDGING THE GAP 1333 00:57:39,880 --> 00:57:42,720 BETWEEN MULTIPLE SKILLS AND 1334 00:57:42,720 --> 00:57:43,040 ASPECTS. 1335 00:57:43,040 --> 00:57:45,360 THIS IS CORRESPONDING TO THE 1336 00:57:45,360 --> 00:57:47,480 FIRST BULLET IN THE PREVIOUS 1337 00:57:47,480 --> 00:57:47,920 SLIDE. 1338 00:57:47,920 --> 00:57:50,600 THE SECOND IS TO GUIDE FURTHER 1339 00:57:50,600 --> 00:57:52,160 DEVELOPMENT BY EMPHASIZING 1340 00:57:52,160 --> 00:57:55,480 TECHNOLOGIES SUGGESTED AT A 1341 00:57:55,480 --> 00:58:00,800 WORKSHOP INSTEAD OF LETTING 1342 00:58:00,800 --> 00:58:03,080 INVESTIGATORS IN THE FIELD. 1343 00:58:03,080 --> 00:58:04,360 THE FIRST IS TO ENCOURAGE OUT OF 1344 00:58:04,360 --> 00:58:06,760 THE BOX THINKING. 1345 00:58:06,760 --> 00:58:10,280 WE DO BELIEVE THE TECHNOLOGIES 1346 00:58:10,280 --> 00:58:16,120 CANNOT BE CONCEIVED BY 1347 00:58:16,120 --> 00:58:17,600 CONVENTIONAL WISDOM MAY MAKE A 1348 00:58:17,600 --> 00:58:19,360 HUGE IMPACT IN THE FIELD. 1349 00:58:19,360 --> 00:58:23,960 HOWEVER, WE REALLY DON'T KNOW 1350 00:58:23,960 --> 00:58:27,480 WHAT THE TECHNOLOGIES ARE AS A 1351 00:58:27,480 --> 00:58:32,400 RESULT WE WANT TO ENCOURAGE SUCH 1352 00:58:32,400 --> 00:58:32,720 THINK. 1353 00:58:32,720 --> 00:58:34,000 THAT IS OUR GOAL. 1354 00:58:34,000 --> 00:58:37,320 WHAT IS OUR STRATEGY TO ACHIEVE 1355 00:58:37,320 --> 00:58:37,520 THAT? 1356 00:58:37,520 --> 00:58:40,520 WE BELIEVE IT'S A PHASED AWARD 1357 00:58:40,520 --> 00:58:42,800 MECHANISM IS THE BEST TO PROMOTE 1358 00:58:42,800 --> 00:58:47,200 INNOVATION WHILE REDUCING THE 1359 00:58:47,200 --> 00:58:48,280 RISK. 1360 00:58:48,280 --> 00:58:50,360 BECAUSE SOME OF THE TECHNOLOGY 1361 00:58:50,360 --> 00:58:55,560 OCCURRED HERE OF HIGH RISK. 1362 00:58:55,560 --> 00:59:01,760 WE DO NEED TO FIGURE OUT THE 1363 00:59:01,760 --> 00:59:05,240 FEASIBILITY BEFORE THE CONCEPT 1364 00:59:05,240 --> 00:59:10,640 CANNOT BE FOR HUMAN IMAGING 1365 00:59:10,640 --> 00:59:11,920 WITHOUT RISKING TOO MUCH MONEY 1366 00:59:11,920 --> 00:59:13,120 ON THAT. 1367 00:59:13,120 --> 00:59:15,240 THIS IS THE GENERAL STRATEGY. 1368 00:59:15,240 --> 00:59:17,520 HERE IS AN EXAMPLE OF HOW WE CAN 1369 00:59:17,520 --> 00:59:18,680 IMPLEMENT IT. 1370 00:59:18,680 --> 00:59:21,160 I SHOULD MENTION WE'RE TALKING 1371 00:59:21,160 --> 00:59:26,000 ABOUT CONCEPT HERE AND CAN HAVE 1372 00:59:26,000 --> 00:59:26,480 DIFFERENT APPROACHES. 1373 00:59:26,480 --> 00:59:30,360 I THINK WE THINK THIS IS A GOOD 1374 00:59:30,360 --> 00:59:30,600 EXAMPLE. 1375 00:59:30,600 --> 00:59:34,280 DOESN'T MEAN THIS IS THE ONLY 1376 00:59:34,280 --> 00:59:34,520 EXAMPLE. 1377 00:59:34,520 --> 00:59:38,280 SO DURING THE PHASE 1, WE WILL 1378 00:59:38,280 --> 00:59:43,480 ALLOW UP TO THREE YEARS OF THE 1379 00:59:43,480 --> 00:59:45,200 BUDGET TO LET THE INVESTIGATOR 1380 00:59:45,200 --> 00:59:49,680 PROVE THE FEASIBILITY OF NEW 1381 00:59:49,680 --> 00:59:49,920 CONCEPT. 1382 00:59:49,920 --> 00:59:52,520 HERE'S THE TECHNOLOGY 1383 00:59:52,520 --> 00:59:55,160 FEASIBILITY WHETHER YOU CAN VIEW 1384 00:59:55,160 --> 00:59:57,760 IT OR NOT AND ALSO IS THE 1385 00:59:57,760 --> 00:59:58,720 PROJECT FEASIBILITY. 1386 00:59:58,720 --> 01:00:01,280 THAT MEANS YOU WANT TO BUILD IT 1387 01:00:01,280 --> 01:00:06,480 WITHIN THE GIVEN TIME FRAME AND 1388 01:00:06,480 --> 01:00:08,520 WHAT IS THE SCOPE OF THE 1389 01:00:08,520 --> 01:00:09,200 PROJECT. 1390 01:00:09,200 --> 01:00:09,960 AFTER FIGURING OUT THE 1391 01:00:09,960 --> 01:00:15,200 FEASIBILITY OF THE TECHNOLOGY OR 1392 01:00:15,200 --> 01:00:18,760 PROJECT, THE PROJECT CAN GO TO 1393 01:00:18,760 --> 01:00:20,600 THE SECOND PHASE WHICH GIVEN 1394 01:00:20,600 --> 01:00:23,640 MORE TIME AND BUDGET TO FULLY 1395 01:00:23,640 --> 01:00:28,640 DEVELOP THE FUNCTIONAL PROTOTYPE 1396 01:00:28,640 --> 01:00:30,920 WITH FIRST IN HUMAN IMAGING 1397 01:00:30,920 --> 01:00:33,320 RESULT AND THIS IS WHERE WE 1398 01:00:33,320 --> 01:00:34,760 RECEIVED SOME COMMENTS. 1399 01:00:34,760 --> 01:00:38,000 SOME MEMBERS SUGGEST GIVEN THE 1400 01:00:38,000 --> 01:00:42,560 FIVE YEAR GRANT SO FOR TRULY 1401 01:00:42,560 --> 01:00:44,480 INNOVATIVE IDEA FOR OUT OF THE 1402 01:00:44,480 --> 01:00:46,520 BOX THINKERS IS PROBABLY TOO 1403 01:00:46,520 --> 01:00:50,640 SHORT TO DEVELOP THE CONCEPT ALL 1404 01:00:50,640 --> 01:00:56,160 THE WAY TO FIRST IN HUMAN 1405 01:00:56,160 --> 01:00:57,760 IMAGING. 1406 01:00:57,760 --> 01:01:00,760 WE THINK THIS IS POSSIBLE 1407 01:01:00,760 --> 01:01:01,760 DEPENDING ON THE NATURE OF THE 1408 01:01:01,760 --> 01:01:04,960 TECHNOLOGY AND THE STARTING 1409 01:01:04,960 --> 01:01:09,880 POINT, FOR INSTANCE, FOR SOME 1410 01:01:09,880 --> 01:01:12,240 AGENTS MAY TAKE FIVE OR 10 YEARS 1411 01:01:12,240 --> 01:01:15,240 TO DEVELOP A CONCEPT FOR A FIRST 1412 01:01:15,240 --> 01:01:15,960 IN HUMAN SUBJECT. 1413 01:01:15,960 --> 01:01:19,840 ON THE OTHER HAND, WE SHOULD 1414 01:01:19,840 --> 01:01:21,600 KEEP A SIGNIFICANT CONCEPT IN 1415 01:01:21,600 --> 01:01:27,960 MIND IF YOU ALLOW INVESTIGATOR 1416 01:01:27,960 --> 01:01:31,600 TO STOP SHORT OF HUMAN IMAGING 1417 01:01:31,600 --> 01:01:33,160 PROBABLY WOULD HURT THE 1418 01:01:33,160 --> 01:01:34,360 SIGNIFICANCE OF THE PROJECT. 1419 01:01:34,360 --> 01:01:39,960 SOMEWHERE IN THE MIDDLE IS 1420 01:01:39,960 --> 01:01:43,280 PROBABLY 1421 01:01:43,280 --> 01:01:46,280 PROBABLY IS BETTER AND WE 1422 01:01:46,280 --> 01:01:46,960 WELCOME INPUT IN THE DISCUSSION 1423 01:01:46,960 --> 01:01:50,240 SESSION. 1424 01:01:50,240 --> 01:01:52,320 SO THE TASK FORCE ALSO 1425 01:01:52,320 --> 01:01:53,240 CHALLENGED OURSELVES WITH THE 1426 01:01:53,240 --> 01:01:55,960 QUESTION, CAN WE DO IT BETTER? 1427 01:01:55,960 --> 01:01:57,360 LOOKING AROUND THE BRAIN 1428 01:01:57,360 --> 01:01:58,400 INITIATIVE THERE'S MANY EXAMPLES 1429 01:01:58,400 --> 01:02:02,160 OF TEAM-BASED SCIENCE. 1430 01:02:02,160 --> 01:02:04,960 FOR EXAMPLE, THE BRAIN 1431 01:02:04,960 --> 01:02:07,440 INITIATIVE CELLS CONSORTIUM AND 1432 01:02:07,440 --> 01:02:09,960 THE BRAIN INITIATIVE CELL CENSUS 1433 01:02:09,960 --> 01:02:16,000 NETWORK THE BICCN WHICH JOHN HAS 1434 01:02:16,000 --> 01:02:23,400 PRESENTED A MOMENT AGO. 1435 01:02:23,400 --> 01:02:30,320 THIS CONSORTIUM COORDINATED 1436 01:02:30,320 --> 01:02:37,280 PROJECTS AND THERE WAS A 1437 01:02:37,280 --> 01:02:39,320 PUBLISHING OF PAPERS IN THE 1438 01:02:39,320 --> 01:02:41,760 PRIMARY MOTOR CORTEX ACROSS 1439 01:02:41,760 --> 01:02:42,880 DIFFERENT SPECIES INTO 14 1440 01:02:42,880 --> 01:02:45,160 CATEGORIES AND MORE THAN 100 1441 01:02:45,160 --> 01:02:46,520 TYPES. 1442 01:02:46,520 --> 01:02:51,960 SO LOOKING BACK INTO OUR 1443 01:02:51,960 --> 01:02:53,160 NON-INVASIVE TECHNOLOGY 1444 01:02:53,160 --> 01:02:54,240 DEVELOPMENT, THIS KIND OF 1445 01:02:54,240 --> 01:02:55,880 TEAM-BASED SCIENCE IS REALLY 1446 01:02:55,880 --> 01:02:57,360 LACKING ESPECIALLY IF YOU WANT 1447 01:02:57,360 --> 01:02:59,000 TO ENCOURAGE THE DEVELOPMENT OF 1448 01:02:59,000 --> 01:03:03,480 A HIGHLY-INTERGREAT GRATED SYSTEM AND 1449 01:03:03,480 --> 01:03:06,840 WE NEED TO ENCOURAGE THE 1450 01:03:06,840 --> 01:03:10,520 CROSS-TALK BETWEEN DIFFERENT 1451 01:03:10,520 --> 01:03:10,880 DEVELOPERS. 1452 01:03:10,880 --> 01:03:12,480 AS A RESULT WE THINK A 1453 01:03:12,480 --> 01:03:14,160 CONSORTIUM WILL BE MUCH NEEDED 1454 01:03:14,160 --> 01:03:19,280 IN THE NEXT PHASE OF THE BRAIN 1455 01:03:19,280 --> 01:03:24,000 INITIATIVE JUST COMPROMISED OF 1456 01:03:24,000 --> 01:03:30,320 STIMULATION OF THE RESEARCH 1457 01:03:30,320 --> 01:03:32,720 IDEAS AND WE WOULD ORGANIZE 1458 01:03:32,720 --> 01:03:34,920 MULTIPLE ANNUAL MEETINGS ON 1459 01:03:34,920 --> 01:03:39,920 TOPICS OF BRAIN IMAGING, ASK AN 1460 01:03:39,920 --> 01:03:43,960 INVESTIGATOR TO PRESENT THEIR 1461 01:03:43,960 --> 01:03:46,040 PROJECT PROGRESS AND FUND THE 1462 01:03:46,040 --> 01:03:46,840 NEURO TECHNOLOGY DEVELOPMENT TO 1463 01:03:46,840 --> 01:03:52,560 PARTICIPATE. 1464 01:03:52,560 --> 01:03:56,520 WE ALSO PLAN TO FORM AN AD HOC 1465 01:03:56,520 --> 01:04:02,040 SUBGROUP ON ISSUES OF CONCERNS 1466 01:04:02,040 --> 01:04:04,520 ACROSS THE CONSORTIUM AS TWO 1467 01:04:04,520 --> 01:04:08,920 WORK SHOPS AND A BIG CONCERN IS 1468 01:04:08,920 --> 01:04:14,000 THE PRACTICE AND STANDARDIZE THE 1469 01:04:14,000 --> 01:04:15,960 DATA FORMAT TO ALLOW OTHER 1470 01:04:15,960 --> 01:04:17,200 GROUPS TO ANALYZE THE DATA 1471 01:04:17,200 --> 01:04:20,640 ACQUIRED BY SOME AWARDEES. 1472 01:04:20,640 --> 01:04:27,240 THAT'S VERY IMPORTANT AND THE 1473 01:04:27,240 --> 01:04:29,960 FUNCTIONAL MR COMMUNITY TO 1474 01:04:29,960 --> 01:04:35,160 IMPROVE THE EFFECT SIZE OF SOME 1475 01:04:35,160 --> 01:04:38,440 STUDIES AND THIS KIND OF 1476 01:04:38,440 --> 01:04:39,360 CROSS-SITE ISSUES WILL BE 1477 01:04:39,360 --> 01:04:42,000 DISCUSSED BY THE AD HOC GROUPS 1478 01:04:42,000 --> 01:04:51,680 AND WE THINK BY USING THIS MAXIM 1479 01:04:51,680 --> 01:04:54,160 WE CAT GET BETTER INNOVATIVE 1480 01:04:54,160 --> 01:04:58,400 TECHNOLOGY MANAGEMENT AND WE'RE 1481 01:04:58,400 --> 01:04:59,840 PUTTING IT TO THE FUNDING 1482 01:04:59,840 --> 01:05:01,800 OPPORTUNITY ANNOUNCEMENT AND 1483 01:05:01,800 --> 01:05:03,240 NOTICE OF WARD. 1484 01:05:03,240 --> 01:05:04,120 AS A RESULT THE INVESTIGATORS 1485 01:05:04,120 --> 01:05:07,920 FUNDED BY THE CONCEPT WILL BE 1486 01:05:07,920 --> 01:05:12,880 REQUIRED TO PARTICIPATE THIS 1487 01:05:12,880 --> 01:05:13,360 CONSORTIUM. 1488 01:05:13,360 --> 01:05:14,760 NEXT SLIDE, PLEASE. 1489 01:05:14,760 --> 01:05:15,160 THAT'S IT. 1490 01:05:15,160 --> 01:05:21,000 I HOPE THIS GIVES YOU A PICTURE 1491 01:05:21,000 --> 01:05:23,960 OF THIS CONCEPT AND I'LL OPEN 1492 01:05:23,960 --> 01:05:25,920 THE FLOOR FOR FURTHER COMMENTS, 1493 01:05:25,920 --> 01:05:26,240 DISCUSSION. 1494 01:05:26,240 --> 01:05:29,520 >> THANK YOU, SHUMIN. 1495 01:05:29,520 --> 01:05:31,960 WE TYPICALLY IS OUR MEMBERS TO 1496 01:05:31,960 --> 01:05:41,520 DO A MORE IN DEP -- DEPTH LOOK 1497 01:05:41,520 --> 01:05:43,960 AT THE CONCEPT AND START THE 1498 01:05:43,960 --> 01:05:44,280 DISCUSSION. 1499 01:05:44,280 --> 01:05:45,240 BRUCE. 1500 01:05:45,240 --> 01:05:49,840 >> STARTING OUT WITH WHAT MAY 1501 01:05:49,840 --> 01:05:51,080 NOT BE A GREAT SURPRISE OVERALL 1502 01:05:51,080 --> 01:05:53,600 I'M VERY ENTHUSIASTIC ABOUT THIS 1503 01:05:53,600 --> 01:05:53,880 IDEA. 1504 01:05:53,880 --> 01:05:59,000 LOTS OF CLEAR THOUGHT HAS GONE 1505 01:05:59,000 --> 01:06:00,440 INTO THE GROUP. 1506 01:06:00,440 --> 01:06:05,800 I THINK SHUMIN AND HIS TEAM'S 1507 01:06:05,800 --> 01:06:07,360 ARTICULATION OF WHEN THE 1508 01:06:07,360 --> 01:06:09,240 PROGRESS MADE IS ON THE MARK BUT 1509 01:06:09,240 --> 01:06:14,360 MOST IMPORTANT HIS CONCLUSION 1510 01:06:14,360 --> 01:06:16,360 THERE'S SIGNIFICANT ADDITIONAL 1511 01:06:16,360 --> 01:06:19,760 PROGRESS TO BE MADE I THINK IS 1512 01:06:19,760 --> 01:06:21,160 LIES SUPPORTED BY WHERE WE ARE 1513 01:06:21,160 --> 01:06:25,160 AND AREAS FLOATING IN THE 1514 01:06:25,160 --> 01:06:25,440 COMMUNITY. 1515 01:06:25,440 --> 01:06:27,720 SOME OF THE THEMES I THOUGHT 1516 01:06:27,720 --> 01:06:30,520 WERE STRONG AND MIGHT EVEN BE 1517 01:06:30,520 --> 01:06:33,520 HIGHLIGHTED WHEN AN ULTIMATE RFA 1518 01:06:33,520 --> 01:06:38,040 MIGHT APPEAR, THE PUSH FROM 1519 01:06:38,040 --> 01:06:41,160 MACRO SCALE TO MESO SCALE IS 1520 01:06:41,160 --> 01:06:43,600 CERTAINLY ONE THAT SHUMIN HAS 1521 01:06:43,600 --> 01:06:43,920 ALLUDED TO. 1522 01:06:43,920 --> 01:06:48,640 I THINK WE'RE REALLY ON THE 1523 01:06:48,640 --> 01:06:51,080 THRESHOLD NOW OF USING SOME OF 1524 01:06:51,080 --> 01:06:54,360 OUR TOOLS AND CERTAINLY MR TODAY 1525 01:06:54,360 --> 01:06:56,520 AND PROGRAMS IN THE FUTURE 1526 01:06:56,520 --> 01:06:59,680 INTEGRATION OF OPTICS AND 1527 01:06:59,680 --> 01:07:01,440 ACOUSTICS, FOR EXAMPLE, TO BE 1528 01:07:01,440 --> 01:07:07,920 ABLE TO MEASURE BRAIN ACTIVITY 1529 01:07:07,920 --> 01:07:11,000 AT DIFFERENT LEVELS AND ONE 1530 01:07:11,000 --> 01:07:12,480 THESE THINGS WHERE EVEN 1531 01:07:12,480 --> 01:07:15,960 RELATIVELY MODEST IMPROVEMENTS 1532 01:07:15,960 --> 01:07:17,720 IN THE TECHNOLOGY CAN TAKE US TO 1533 01:07:17,720 --> 01:07:21,960 THE POINT WHERE WE CAN RELIABLY 1534 01:07:21,960 --> 01:07:23,640 DO THESE EXPERIMENTS ACROSS THE 1535 01:07:23,640 --> 01:07:24,760 ENTIRE BRAIN WHICH I THINK WILL 1536 01:07:24,760 --> 01:07:26,840 MAKE A PROFOUND IMPACT BECAUSE 1537 01:07:26,840 --> 01:07:31,160 WE REALLY DON'T KNOW MUCH ABOUT 1538 01:07:31,160 --> 01:07:33,400 HUMAN BRAIN MESO SCALE 1539 01:07:33,400 --> 01:07:34,400 ARCHITECTURE AND FUNCTION AND 1540 01:07:34,400 --> 01:07:35,920 YET I THINK WE'RE GAINING ON THE 1541 01:07:35,920 --> 01:07:42,960 ABILITY TO DO THAT. 1542 01:07:42,960 --> 01:07:45,400 IN A SIMILAR VEIN, THE TEMPORAL 1543 01:07:45,400 --> 01:07:47,920 RESOLUTION TO USE THE TECHNIQUES 1544 01:07:47,920 --> 01:07:50,000 ESPECIALLY THOSE MAYBE BASED ON 1545 01:07:50,000 --> 01:07:59,160 HUMAN DYNAMICS IS FOR BEHAVIOR 1546 01:07:59,160 --> 01:08:01,240 IN THE DELTA RANGE AND SLOW 1547 01:08:01,240 --> 01:08:02,360 WAVES. 1548 01:08:02,360 --> 01:08:03,920 IF WE CAN CONTINUE TO PUSH 1549 01:08:03,920 --> 01:08:05,080 THROUGH ON THE SENSITIVITY 1550 01:08:05,080 --> 01:08:07,760 ISSUES SHUMIN LAID OUT, I THINK 1551 01:08:07,760 --> 01:08:09,760 THAT SHOULD ALLOW US TO LOOK AT 1552 01:08:09,760 --> 01:08:13,800 WHOLE BRAIN INTEGRATION OF 1553 01:08:13,800 --> 01:08:14,760 BEHAVIORS AT SOME FREQUENCIES 1554 01:08:14,760 --> 01:08:18,960 AND THEN WITH THE INTEGRATION OF 1555 01:08:18,960 --> 01:08:22,520 TECHNOLOGIES THE 1556 01:08:22,520 --> 01:08:23,480 ELECTROPHYSIOLOGICAL TOOLS 1557 01:08:23,480 --> 01:08:26,240 CERTAINLY PUSH TO A BROAD RANGE 1558 01:08:26,240 --> 01:08:27,760 OF COHERENT FREQUENCIES WE CAN 1559 01:08:27,760 --> 01:08:31,000 LOOK AT WHICH HIGHLIGHTS ANOTHER 1560 01:08:31,000 --> 01:08:33,800 ELEMENT SHUMIN REINFORCED HERE 1561 01:08:33,800 --> 01:08:35,960 WHICH IS THE NOTION OF 1562 01:08:35,960 --> 01:08:39,360 ENCOURAGING THE INTEGRATION OF 1563 01:08:39,360 --> 01:08:39,720 TECHNOLOGIES. 1564 01:08:39,720 --> 01:08:41,080 CERTAINLY THERE'S BEEN LOTS OF 1565 01:08:41,080 --> 01:08:46,160 PROGRESS IN THE PAST AND THINGS 1566 01:08:46,160 --> 01:08:47,720 LIKE INTEGRATING MR AND PET BUT 1567 01:08:47,720 --> 01:08:50,160 I THINK THE INTEGRATION OF 1568 01:08:50,160 --> 01:08:52,160 OPTICS AND ACOUSTICS WE'VE SEEN 1569 01:08:52,160 --> 01:08:53,840 GOOD PROGRESS BUT MORE TO BE 1570 01:08:53,840 --> 01:08:56,080 DONE PUSHING THAT IN THE HUMAN 1571 01:08:56,080 --> 01:08:59,360 REALM AND ACOUSTICS AND HUMAN 1572 01:08:59,360 --> 01:09:01,840 PHYSIOLOGY AND WE'VE SEEN THE 1573 01:09:01,840 --> 01:09:04,240 BEGINNINGS OF ACTIVITY BUT THESE 1574 01:09:04,240 --> 01:09:09,160 DOMAINS ARE REALLY ONES THAT ARE 1575 01:09:09,160 --> 01:09:11,920 RIPE FOR CREATIVE INPUT AND 1576 01:09:11,920 --> 01:09:13,360 SIGNIFICANT INVESTMENTS TO PUSH 1577 01:09:13,360 --> 01:09:14,640 THEM THROUGH AND HOLD GREAT 1578 01:09:14,640 --> 01:09:17,120 PROMISE AT LEAST IN STUDYING THE 1579 01:09:17,120 --> 01:09:19,960 CORTEX TO BE ABLE TO ROUTINE GET 1580 01:09:19,960 --> 01:09:22,200 US TO SENSITIVITY AND SPATIAL 1581 01:09:22,200 --> 01:09:24,360 AND TEMPORAL RESOLUTIONS AT THE 1582 01:09:24,360 --> 01:09:25,360 MESO SCALE WE'RE LOOKING AT. 1583 01:09:25,360 --> 01:09:26,360 I THINK ANOTHER OPPORTUNITY THAT 1584 01:09:26,360 --> 01:09:28,480 WAS KIND OF ALLUDED TO AND 1585 01:09:28,480 --> 01:09:30,760 SOMETHING WE CAN CONSIDER BEING 1586 01:09:30,760 --> 01:09:35,960 MORE EXPLICIT ABOUT IS THE 1587 01:09:35,960 --> 01:09:38,520 NEURAL CHEMICAL SIDE OF THINGS 1588 01:09:38,520 --> 01:09:40,120 AND SHUMIN POINTED OUT THE 1589 01:09:40,120 --> 01:09:42,960 INVESTMENT IN PET TECHNOLOGY 1590 01:09:42,960 --> 01:09:45,440 REALLY OFFER ONE OF THESE ORDER 1591 01:09:45,440 --> 01:09:49,760 OF MAGNITUDE IN IMPROVEMENT IN 1592 01:09:49,760 --> 01:09:50,760 SENSITIVITY AND MAYBE WITH A.I. 1593 01:09:50,760 --> 01:09:53,640 TOOLS MAYBE EVEN MORE THAN THAT. 1594 01:09:53,640 --> 01:09:56,160 SOME SAY UPWARDS OF A FACTOR OF 1595 01:09:56,160 --> 01:09:57,520 100 IN SENSITIVITY. 1596 01:09:57,520 --> 01:09:58,480 THAT'S A BIG DEAL. 1597 01:09:58,480 --> 01:10:01,440 THAT THEN ALLOWS YOU TO IMAGINE, 1598 01:10:01,440 --> 01:10:03,120 FOR EXAMPLE, STUDYING CHILDREN 1599 01:10:03,120 --> 01:10:07,120 WITH NUCLEAR TECHNIQUES WHICH 1600 01:10:07,120 --> 01:10:09,560 YOU WOULDN'T OTHERWISE CONSIDER 1601 01:10:09,560 --> 01:10:11,240 UNDER CURRENT DOSE REGIMES BUT 1602 01:10:11,240 --> 01:10:13,320 WHEN THEY'RE NO GREATER THAN 1603 01:10:13,320 --> 01:10:17,280 WHAT YOU WOULD EXPECT FROM A 1604 01:10:17,280 --> 01:10:20,680 MODERN AIRLINE FLIGHT NOW THE 1605 01:10:20,680 --> 01:10:22,720 IRB MAY LOOK UPON THOSE 1606 01:10:22,720 --> 01:10:23,000 DIFFERENTLY. 1607 01:10:23,000 --> 01:10:24,240 AND I THINK THERE'S 1608 01:10:24,240 --> 01:10:27,680 OPPORTUNITIES NATIONALLY TO NET 1609 01:10:27,680 --> 01:10:29,920 EFFORTS IN DEVELOP THE 1610 01:10:29,920 --> 01:10:34,240 NEUROCHEMICAL ARMAMENTARIAN WORK 1611 01:10:34,240 --> 01:10:35,960 AND NOT SURE HOW IT WOULD FIT 1612 01:10:35,960 --> 01:10:39,560 WITH THE RFA THERE BUT MAYBE 1613 01:10:39,560 --> 01:10:42,720 THERE'S OPPORTUNITIES TO 1614 01:10:42,720 --> 01:10:44,280 ENCOURAGE LINKAGE BETWEEN THE 1615 01:10:44,280 --> 01:10:45,120 NEURAL CHEMICAL OPPORTUNITIES 1616 01:10:45,120 --> 01:10:47,920 AND ALL THE GREAT WORK HAPPENING 1617 01:10:47,920 --> 01:10:50,960 IN THE CELL CENSUS I THINK IS A 1618 01:10:50,960 --> 01:10:51,960 GREAT OPPORTUNITY. 1619 01:10:51,960 --> 01:10:53,360 ONE OF THE CHALLENGES I THINK 1620 01:10:53,360 --> 01:10:55,960 WE'LL HAVE AS A FIELD, AND WE 1621 01:10:55,960 --> 01:10:57,640 SAW THIS FROM THE VERY FIRST 1622 01:10:57,640 --> 01:11:00,600 ROUND, I REMEMBER THE FIRST RFAs 1623 01:11:00,600 --> 01:11:03,920 WHICH WERE PRETTY EXPLICIT IN 1624 01:11:03,920 --> 01:11:05,720 LOOKING FOR OUT OF THE BOX 1625 01:11:05,720 --> 01:11:06,040 IDEAS. 1626 01:11:06,040 --> 01:11:11,960 IN FACT THERE WAS EVEN LANGUAGE 1627 01:11:11,960 --> 01:11:14,760 WRITTEN IN IT SHOULDN'T BE 1628 01:11:14,760 --> 01:11:16,000 CONVENTIONAL THINGS BUT WE HAVE 1629 01:11:16,000 --> 01:11:18,200 RETURN ON INVESTMENT IN BIG 1630 01:11:18,200 --> 01:11:18,520 MAGNETS. 1631 01:11:18,520 --> 01:11:19,880 THAT'S WHAT THE STUDY SECTION 1632 01:11:19,880 --> 01:11:20,960 WENT FOR. 1633 01:11:20,960 --> 01:11:22,560 SO I THINK ONE OF THE REAL 1634 01:11:22,560 --> 01:11:23,960 CHALLENGES WE HAVE IN THIS IS 1635 01:11:23,960 --> 01:11:27,560 OUT OF THE BOX THINKING IS NOT 1636 01:11:27,560 --> 01:11:30,520 LIES ACCOMMODATED BY A 1637 01:11:30,520 --> 01:11:31,960 CONVENTIONAL STUDY SECTION 1638 01:11:31,960 --> 01:11:36,120 DYNAMICS. 1639 01:11:36,120 --> 01:11:37,760 SO THAT'S A CHALLENGE I KNOW YOU 1640 01:11:37,760 --> 01:11:38,960 FOLKS UNDERSTAND BUT ESPECIALLY 1641 01:11:38,960 --> 01:11:42,160 IMPORTANT WHEN YOU REALLY WANT 1642 01:11:42,160 --> 01:11:45,440 TO PUSH IDEAS THAT DON'T HAVE A 1643 01:11:45,440 --> 01:11:46,280 LOT OF PRELIMINARY DATA AND 1644 01:11:46,280 --> 01:11:48,120 PEOPLE AREN'T FAMILIAR WITH BUT 1645 01:11:48,120 --> 01:11:50,280 ALMOST BY DEFINITION THERE'S NOT 1646 01:11:50,280 --> 01:11:52,160 GOING TO BE A ROOM OF PEOPLE WHO 1647 01:11:52,160 --> 01:11:53,520 UNDERSTAND THE TECHNOLOGY AND 1648 01:11:53,520 --> 01:11:55,000 DEVELOPMENT BECAUSE IF IT WERE 1649 01:11:55,000 --> 01:11:58,200 IT WOULDN'T BE OUT OF THE BOX 1650 01:11:58,200 --> 01:11:58,440 ANYMORE. 1651 01:11:58,440 --> 01:12:03,960 HOW TO GET THOSE IDEAS THROUGH 1652 01:12:03,960 --> 01:12:05,440 STUDY SECTIONS WILL HAVE TO 1653 01:12:05,440 --> 01:12:09,000 DEPEND ON HOW THE RFA'S WRITTEN 1654 01:12:09,000 --> 01:12:12,440 AND SOMETHING TO THE DEGREE OF 1655 01:12:12,440 --> 01:12:14,480 HOW WE ORGANIZE THOSE GROUPS. 1656 01:12:14,480 --> 01:12:16,560 THE CONSORTIUM IS A GREAT IDEA. 1657 01:12:16,560 --> 01:12:20,280 ONE THING I MIGHT ADD TO THAT 1658 01:12:20,280 --> 01:12:21,480 AND THE NIH TALKS ABOUT DATA 1659 01:12:21,480 --> 01:12:22,840 SHARING AS ROUTINE. 1660 01:12:22,840 --> 01:12:28,240 I THINK THIS IS A DOMAIN WHERE 1661 01:12:28,240 --> 01:12:29,680 CONCERTED EFFORTS AROUND 1662 01:12:29,680 --> 01:12:31,240 INCLUDING EXPLICIT PLANS AROUND 1663 01:12:31,240 --> 01:12:33,760 DATA SHARING AND RESOURCES THAT 1664 01:12:33,760 --> 01:12:35,520 PEOPLE NEED TO UNDERSTAND THEY 1665 01:12:35,520 --> 01:12:37,480 HAVE TO RESOURCE DATA SHARING. 1666 01:12:37,480 --> 01:12:38,520 THEY CAN'T JUST SAY THEY'RE 1667 01:12:38,520 --> 01:12:40,280 GOING SHARE IT. 1668 01:12:40,280 --> 01:12:41,760 IT TAKES EFFORT AND MONEY TO 1669 01:12:41,760 --> 01:12:43,360 MAKE THAT HAPPEN. 1670 01:12:43,360 --> 01:12:47,880 I WOULD AT LEAST ENCOURAGE THAT 1671 01:12:47,880 --> 01:12:48,440 TO BE SOMETHING EXPLICIT 1672 01:12:48,440 --> 01:12:49,720 EVALUATION CRITERIA AND MAKE IT 1673 01:12:49,720 --> 01:12:51,960 CLEAR WE EXPECT THAT IT DOESN'T 1674 01:12:51,960 --> 01:12:56,520 COME FOR FREE. 1675 01:12:56,520 --> 01:12:57,800 THEN YOU TALKED ABOUT THE ISSUE 1676 01:12:57,800 --> 01:13:01,880 OF TIMING AND A LOVE THE 1677 01:13:01,880 --> 01:13:02,400 TWO-PHASED MECHANISM. 1678 01:13:02,400 --> 01:13:03,880 IT MAKES SENSE BUT THE NOTION 1679 01:13:03,880 --> 01:13:06,000 YOU WOULD WANT TO GET TO FIRST 1680 01:13:06,000 --> 01:13:08,080 IN HUMAN USE IS GREAT BUT OF 1681 01:13:08,080 --> 01:13:10,520 COURSE DOING THAT IN FIVE YEARS 1682 01:13:10,520 --> 01:13:12,040 IS CHALLENGING AND IF GETTING TO 1683 01:13:12,040 --> 01:13:16,120 HUMANS IN FIVE YEARS IS A REVIEW 1684 01:13:16,120 --> 01:13:17,760 CRITERIA, THAT MAY DISCOURAGE 1685 01:13:17,760 --> 01:13:19,720 SOME OF THE OUT OF THE BOX THINK 1686 01:13:19,720 --> 01:13:20,600 YOU'D LIKE WHERE THOSE TIME 1687 01:13:20,600 --> 01:13:23,680 FRAMES ARE LIKELY TO BE LONGER 1688 01:13:23,680 --> 01:13:27,120 AND REVIEWERS MIGHT 1689 01:13:27,120 --> 01:13:27,960 REALISTICALLY UNDERSTAND AND HOW 1690 01:13:27,960 --> 01:13:31,960 TO BALANCE THOSE I LIKE THE FAZE 1691 01:13:31,960 --> 01:13:34,520 PHASED APPROACH TO REJECT AREAS 1692 01:13:34,520 --> 01:13:37,200 THAT AREN'T MAKE PROGRESS BUT TO 1693 01:13:37,200 --> 01:13:38,600 MAKE SURE PROGRESS DON'T GET 1694 01:13:38,600 --> 01:13:39,600 KILLED BECAUSE REVIEWERS 1695 01:13:39,600 --> 01:13:41,760 PERCEIVE THE NEED TO GET IT INTO 1696 01:13:41,760 --> 01:13:44,280 HUMANS IN THAT FIVE-YEAR TIME 1697 01:13:44,280 --> 01:13:46,520 FRAME I FIND THAT AS TOO GREAT A 1698 01:13:46,520 --> 01:13:46,880 HURDLE. 1699 01:13:46,880 --> 01:13:51,720 WE WOULDN'T WANT TO REJECT THOSE 1700 01:13:51,720 --> 01:13:51,920 IDEAS. 1701 01:13:51,920 --> 01:13:53,520 I KNOW WE WOULDN'T WANT TO 1702 01:13:53,520 --> 01:13:55,560 REJECT THE IDEAS AND SOMETHING I 1703 01:13:55,560 --> 01:13:56,480 ENCOURAGE TO THINK ABOUT MORE 1704 01:13:56,480 --> 01:13:58,760 AND PLENTY OF GREAT STUFF HERE 1705 01:13:58,760 --> 01:13:59,960 AND LOTS OF GREAT OPPORTUNITIES 1706 01:13:59,960 --> 01:14:02,160 TO BEGIN TO CONNECT WHAT WE'RE 1707 01:14:02,160 --> 01:14:03,400 DOING FROM THE TOP DOWN TO WHAT 1708 01:14:03,400 --> 01:14:05,760 OF COURSE IS HAPPENING AT THE 1709 01:14:05,760 --> 01:14:07,760 CELL CENSUS AND 1710 01:14:07,760 --> 01:14:08,760 ELECTROPHYSIOLOGICAL LEVEL FROM 1711 01:14:08,760 --> 01:14:09,920 THE BOTTOM UP. 1712 01:14:09,920 --> 01:14:12,320 >> THANK YOU SO MUCH, BRUCE, FOR 1713 01:14:12,320 --> 01:14:14,760 YOUR SUPPORT AND GREAT COMMENTS. 1714 01:14:14,760 --> 01:14:19,960 AS TO THE FIRST IN HUMAN TEST, 1715 01:14:19,960 --> 01:14:22,920 IT'S TRULY ASPIRATIONAL IN A 1716 01:14:22,920 --> 01:14:23,160 SENSE. 1717 01:14:23,160 --> 01:14:26,480 ALSO BECAUSE IT GOES TO SUPPORT 1718 01:14:26,480 --> 01:14:27,080 HUMAN NEUROSCIENCE. 1719 01:14:27,080 --> 01:14:32,560 IT'S SORT OF DIFFICULT FOR US TO 1720 01:14:32,560 --> 01:14:36,240 GO LOWER AND ON THE OTHER SIDE I 1721 01:14:36,240 --> 01:14:39,880 CONSIDER YOUR COMMENTS 1722 01:14:39,880 --> 01:14:40,760 ESPECIALLY WHETHER THE OUT OF 1723 01:14:40,760 --> 01:14:42,120 THE BOX THINKERS CAN MAKE IT TO 1724 01:14:42,120 --> 01:14:46,360 HUMAN IN FIVE YEARS. 1725 01:14:46,360 --> 01:14:53,880 WE LOOK AT OUR PORTFOLIO AND 1726 01:14:53,880 --> 01:14:55,520 THERE'S CHANGE TO LARGE ANIMALS 1727 01:14:55,520 --> 01:14:57,920 IN FIVE YEARS AND DO NEED A 1728 01:14:57,920 --> 01:15:01,160 TARGET OTHERWISE WE CAN PROPOSE 1729 01:15:01,160 --> 01:15:02,480 SOMETHING WITH NO END RESULT. 1730 01:15:02,480 --> 01:15:04,400 >> I WONDER IF THE TARGET WOULD 1731 01:15:04,400 --> 01:15:05,800 BE RATHER THAN HAVING THE 1732 01:15:05,800 --> 01:15:08,760 PROTOTYPE WORK IN HUMANS, 1733 01:15:08,760 --> 01:15:16,040 BASICALLY EITHER THAT FOR HAVING 1734 01:15:16,040 --> 01:15:18,760 DETAILED MODELLING AND 1735 01:15:18,760 --> 01:15:22,000 PRELIMINARY DATA TO GO TO THE 1736 01:15:22,000 --> 01:15:24,240 BRAIN AND GEOMETRY OF SKULL 1737 01:15:24,240 --> 01:15:25,960 THICKNESS FOR HUMANS AND A WAY 1738 01:15:25,960 --> 01:15:28,480 TO SHOW IT'S HUMAN CAPABLE EVEN 1739 01:15:28,480 --> 01:15:29,680 IF YOU HAVEN'T DONE ALL THE 1740 01:15:29,680 --> 01:15:33,160 ENGINEERING TO GET TO THAT POINT 1741 01:15:33,160 --> 01:15:35,760 BECAUSE I AGREE WITH YOU, IT 1742 01:15:35,760 --> 01:15:37,280 SHOULD BE DEVOTED TO WHAT IT 1743 01:15:37,280 --> 01:15:40,320 TAKES TO IMAGE THE BRAINS OF 1744 01:15:40,320 --> 01:15:40,520 HUMANS. 1745 01:15:40,520 --> 01:15:44,760 THAT MAY BE ANOTHER WAY TO 1746 01:15:44,760 --> 01:15:46,200 PHRASE THINGS EITHER 1747 01:15:46,200 --> 01:15:47,600 DEMONSTRATION OR CLEAR 1748 01:15:47,600 --> 01:15:49,040 DEMONSTRATION BASED ON MODELLING 1749 01:15:49,040 --> 01:15:50,640 AND DATA AND LARGE ANIMALS IT 1750 01:15:50,640 --> 01:15:52,360 WILL BE FEASIBLE TO MOVE TO 1751 01:15:52,360 --> 01:15:52,680 HUMANS. 1752 01:15:52,680 --> 01:15:54,560 THAT MAY BE ANOTHER WAY TO CUT 1753 01:15:54,560 --> 01:15:54,880 IT. 1754 01:15:54,880 --> 01:15:56,160 AND THAT SHOULD BE DOABLE IN 1755 01:15:56,160 --> 01:15:57,640 FIVE YEARS, I AGREE. 1756 01:15:57,640 --> 01:15:59,280 >> BRUCE, THAT'S A GREAT POINT. 1757 01:15:59,280 --> 01:16:00,960 WHAT WE WANT IS A CLEAR PATH NOT 1758 01:16:00,960 --> 01:16:03,000 JUST A PROMISE. 1759 01:16:03,000 --> 01:16:03,960 THANK YOU. 1760 01:16:03,960 --> 01:16:06,320 SUSAN, SHOULD WE MOVE TO THE 1761 01:16:06,320 --> 01:16:08,960 NEXT DISCUSSANTS AND THEN CIRCLE 1762 01:16:08,960 --> 01:16:09,960 BACK FOR GENERAL DISCUSSION? 1763 01:16:09,960 --> 01:16:14,960 THANK YOU, BRUCE. 1764 01:16:14,960 --> 01:16:17,720 >> SURE. 1765 01:16:17,720 --> 01:16:19,160 BRUCE, YOU SAID SO MUCH AND I'LL 1766 01:16:19,160 --> 01:16:21,360 TRY TO HIGHLIGHT IT. 1767 01:16:21,360 --> 01:16:26,280 IT WAS FANTASTIC. 1768 01:16:26,280 --> 01:16:28,400 I'M HUGELY SUPPORTIVE BECAUSE IT 1769 01:16:28,400 --> 01:16:32,280 WILL BE A HUGE IMPACT IN CIRCUIT 1770 01:16:32,280 --> 01:16:33,800 DIAGRAMS AND ACTIVITY IN THE 1771 01:16:33,800 --> 01:16:35,960 DYNAMIC RANGE AND TO THINK ABOUT 1772 01:16:35,960 --> 01:16:37,360 SPATIAL AND TEMPORAL 1773 01:16:37,360 --> 01:16:39,440 CONSIDERATIONS AS WE SCALE UP TO 1774 01:16:39,440 --> 01:16:43,480 HUMAN TO THINK ABOUT CIRCUITS OF 1775 01:16:43,480 --> 01:16:46,880 BEHAVIOR AND ALSO CIRCUIT 1776 01:16:46,880 --> 01:16:47,960 DISORDERS IS OF PROFOUND 1777 01:16:47,960 --> 01:16:51,480 IMPORTANCE AND AT THE POINT WE 1778 01:16:51,480 --> 01:16:57,680 SHOULD ASPIRE TO DO THAT WITH 1779 01:16:57,680 --> 01:16:59,800 OTHER AREAS GETTING ATTENTION IN 1780 01:16:59,800 --> 01:17:02,240 THE BRAIN AND USING A USE CASE 1781 01:17:02,240 --> 01:17:03,240 IS IMPORTANT WHY NOT GAIN 1782 01:17:03,240 --> 01:17:04,840 SOMETHING ABOUT A BEHAVIOR OR 1783 01:17:04,840 --> 01:17:06,720 EVEN A DISORDER. 1784 01:17:06,720 --> 01:17:10,400 I WOULD SUGGEST THAT WE THINK 1785 01:17:10,400 --> 01:17:11,960 HARD ABOUT WHAT WE WOULD 1786 01:17:11,960 --> 01:17:13,200 CHARACTERIZE AS AN IMPORTANT USE 1787 01:17:13,200 --> 01:17:16,400 CASE AS WE MOVE THROUGH THIS 1788 01:17:16,400 --> 01:17:19,000 DEVELOPMENT, THIS SPECTRUM IS 1789 01:17:19,000 --> 01:17:21,520 WHERE THE PROCESS OF DEVELOPING. 1790 01:17:21,520 --> 01:17:26,120 AND MANY DISORDERS COULD VERY BE 1791 01:17:26,120 --> 01:17:28,760 VERY ADAPTABLE TO A KNOWN LESION 1792 01:17:28,760 --> 01:17:31,040 IN A CONNECTION PATHWAY THAT 1793 01:17:31,040 --> 01:17:32,720 COULD MAKE IT VERY GOOD PROOF OF 1794 01:17:32,720 --> 01:17:34,280 PRINCIPLE FOR YOU. 1795 01:17:34,280 --> 01:17:37,320 I ALSO GIVEN I'M REPRESENTING 1796 01:17:37,320 --> 01:17:38,240 NICHD AS WELL AND ACROSS THE 1797 01:17:38,240 --> 01:17:41,560 LIFE SPAN, I THINK WE HAVE TO 1798 01:17:41,560 --> 01:17:43,080 CONSIDER HOW WE'RE GOING THINK 1799 01:17:43,080 --> 01:17:45,040 ABOUT DEVELOPING BRAIN VERSUS 1800 01:17:45,040 --> 01:17:45,520 AGE BRAIN. 1801 01:17:45,520 --> 01:17:47,920 THERE'S ANOTHER DYNAMIC RANGE 1802 01:17:47,920 --> 01:17:49,960 THERE IN THE SAME BRAIN AND WHAT 1803 01:17:49,960 --> 01:17:51,480 DOES HOW ARE WE GOING THINK 1804 01:17:51,480 --> 01:17:52,760 ABOUT THAT MAYBE AT THE ANIMAL 1805 01:17:52,760 --> 01:17:54,440 LEVEL BUT STILL AS WE SCALE TO 1806 01:17:54,440 --> 01:17:56,640 THE HUMAN, WHAT DO WE HAVE TO 1807 01:17:56,640 --> 01:17:59,360 CONSIDER IN A DEGENERATING BRAIN 1808 01:17:59,360 --> 01:18:01,040 VERSUS A DEVELOPING BRAIN WHERE 1809 01:18:01,040 --> 01:18:02,760 FROM ONE WEEK TO THE NEXT IT'S 1810 01:18:02,760 --> 01:18:03,480 QUITE DIFFERENT. 1811 01:18:03,480 --> 01:18:09,840 SO TO REMEMBER THAT. 1812 01:18:09,840 --> 01:18:12,040 I THINK THAT I WANTED TO PICK UP 1813 01:18:12,040 --> 01:18:16,120 ON SOMETHING SAID EARLIER WHERE 1814 01:18:16,120 --> 01:18:21,840 TED ABEL WAS TALKING ABOUT BEING 1815 01:18:21,840 --> 01:18:24,640 BRAIN/NERVOUS SYSTEM CENTRIC. 1816 01:18:24,640 --> 01:18:26,760 AS WE THINK OUT SIDE THE BOX CAN 1817 01:18:26,760 --> 01:18:31,960 WE THINK CONNECTING THE ENTERIC 1818 01:18:31,960 --> 01:18:35,160 NERVOUS SYSTEM AND THE TERRIFIC 1819 01:18:35,160 --> 01:18:36,160 RAL SYSTEM AND I THINK WE'RE 1820 01:18:36,160 --> 01:18:39,640 READY TO DO IT AT SOME LEVEL 1821 01:18:39,640 --> 01:18:42,400 MAYBE NOT IN THE HUMAN BUT MAYBE 1822 01:18:42,400 --> 01:18:44,560 IN SOME EXPERIMENTAL MAN MODELS. 1823 01:18:44,560 --> 01:18:47,840 THAT WOULD BE AN INTERESTING 1824 01:18:47,840 --> 01:18:48,240 PIECE TO CONSIDER. 1825 01:18:48,240 --> 01:18:50,760 I THINK FOR TAKING IT TO THE 1826 01:18:50,760 --> 01:18:54,760 NEXT LEVEL, INTO THE PHASE 1-2 1827 01:18:54,760 --> 01:18:55,880 ADMINISTRATIONS I AGREE 1828 01:18:55,880 --> 01:18:59,000 CONSORTIUM ARE KEY. 1829 01:18:59,000 --> 01:19:02,520 WE HAVE TO THINK ABOUT U 1830 01:19:02,520 --> 01:19:06,240 MECHANISMS OUTSIDE THE R01 AND 1831 01:19:06,240 --> 01:19:16,520 THINK OF GO/NO-GO EXAMPLES LIKE 1832 01:19:16,520 --> 01:19:18,520 THE SHARK TANK APPROACH USED BY 1833 01:19:18,520 --> 01:19:20,960 THE IMAGE INSTITUTE AND 1834 01:19:20,960 --> 01:19:22,240 ANTICIPATING HOW WOULD YOU MAKE 1835 01:19:22,240 --> 01:19:24,520 THOSE CHOICES AND HOW WOULD YOU 1836 01:19:24,520 --> 01:19:29,520 SET THAT UP SO IT'S JUSTIFIED. 1837 01:19:29,520 --> 01:19:31,240 DON'T FORGET TO EXPLICITLY THINK 1838 01:19:31,240 --> 01:19:33,600 OF HOW WE'LL REACH OUT TO THE 1839 01:19:33,600 --> 01:19:36,880 NON-NEURAL SCIENTISTS THE 1840 01:19:36,880 --> 01:19:38,720 ENGINEERS AND THE A.I. AND HOW 1841 01:19:38,720 --> 01:19:40,440 TO BUILD THAT BECAUSE OF COURSE 1842 01:19:40,440 --> 01:19:47,080 IT'S GOING TO BE KEY. 1843 01:19:47,080 --> 01:19:50,080 THE OTHER THING IS I THINK THE 1844 01:19:50,080 --> 01:19:54,600 PHASE 2,IT'S HARD TO SAY FIVE 1845 01:19:54,600 --> 01:19:54,960 YEARS. 1846 01:19:54,960 --> 01:19:59,040 I THINK THAT MAY NEED TO BE 1847 01:19:59,040 --> 01:20:00,760 QUALIFIED OR REMOVED AT THIS 1848 01:20:00,760 --> 01:20:03,680 POINT BECAUSE IT COULD CONSTRAIN 1849 01:20:03,680 --> 01:20:04,440 PEOPLE TO THINK SMALL BECAUSE 1850 01:20:04,440 --> 01:20:05,720 THEY HAVE TO GET SOME PLACE IN 1851 01:20:05,720 --> 01:20:07,400 FIVE YEARS AND IF YOU'RE TRYING 1852 01:20:07,400 --> 01:20:10,600 TO GO BIG AND GO OUTSIDE THE BOX 1853 01:20:10,600 --> 01:20:14,000 YOU MIGHT NOT. 1854 01:20:14,000 --> 01:20:18,080 THEN FINALLY, I THOUGHT THAT YOU 1855 01:20:18,080 --> 01:20:21,400 MIGHT WANT TO ALSO THINK ABOUT 1856 01:20:21,400 --> 01:20:24,960 HOW WE'LL USE NEURO ETHICS TEAM 1857 01:20:24,960 --> 01:20:26,520 HAVING HEARD FROM DR. GREELY 1858 01:20:26,520 --> 01:20:27,040 EARLIER. 1859 01:20:27,040 --> 01:20:29,760 THIS IS KEY BECAUSE YOU MAY BE 1860 01:20:29,760 --> 01:20:32,520 UNCOVERING SOME -- AS YOU MOVE 1861 01:20:32,520 --> 01:20:35,600 INTO THE HUMANS YOU MAY HAVE 1862 01:20:35,600 --> 01:20:37,320 THINGS THAT TO BE SHARED OR 1863 01:20:37,320 --> 01:20:39,280 MANAGED LIKE WE CAN ALL THESE 1864 01:20:39,280 --> 01:20:41,000 OTHER KINDS OF EXPERIMENTAL 1865 01:20:41,000 --> 01:20:41,360 PARADIGMS. 1866 01:20:41,360 --> 01:20:44,120 SO I THINK I'LL STOP THERE. 1867 01:20:44,120 --> 01:20:45,840 THOSE ARE MY THOUGHTS TO ADD TO 1868 01:20:45,840 --> 01:20:49,080 THE AMAZING SUMMARY THAT BRUCE 1869 01:20:49,080 --> 01:20:51,920 GAVE. 1870 01:20:51,920 --> 01:20:53,680 >> THANK YOU SO MUCH, FRANCES. 1871 01:20:53,680 --> 01:20:55,360 >> TODD, DID WANT TO COMMENT AND 1872 01:20:55,360 --> 01:21:00,160 THEN WE CAN HAVE A MORE GENERAL 1873 01:21:00,160 --> 01:21:00,480 DISCUSSION? 1874 01:21:00,480 --> 01:21:02,320 >> SURE, BRUCE AND FRANCES BOTH 1875 01:21:02,320 --> 01:21:03,880 SAID MANY OF THE COMMENTS I 1876 01:21:03,880 --> 01:21:05,480 WOULD GOING TO SAY SO THANK YOU 1877 01:21:05,480 --> 01:21:07,680 FOR DOING ALL THAT WORK. 1878 01:21:07,680 --> 01:21:09,280 I'LL JUST ECHO A FEW OF THE ONES 1879 01:21:09,280 --> 01:21:14,960 I REALLY THINK ARE CRITICAL. 1880 01:21:14,960 --> 01:21:17,360 THE NEUROETHICS ONE TO FINISH 1881 01:21:17,360 --> 01:21:19,800 WHERE FRANCES LEFT OFF TO ME IS 1882 01:21:19,800 --> 01:21:21,960 SOMETHING THAT DID AND FROM 1883 01:21:21,960 --> 01:21:24,040 HANK'S SUMMARY OF THE NEWG, THIS 1884 01:21:24,040 --> 01:21:26,240 IS PARTICULARLY A PLACE WHEN 1885 01:21:26,240 --> 01:21:29,640 WE'RE TALKING ABOUT NEW 1886 01:21:29,640 --> 01:21:31,960 NONINVASIVE HUMANS AND THE NEURO 1887 01:21:31,960 --> 01:21:34,640 ETHICS ISSUES AND WHO WITH 1888 01:21:34,640 --> 01:21:36,400 BENEFIT AND YOU CAN IMAGINE 1889 01:21:36,400 --> 01:21:37,920 BUILDING IN SOMETHING LIKE THE 1890 01:21:37,920 --> 01:21:40,040 PARALLEL TO THE PDP WHERE YOU'RE 1891 01:21:40,040 --> 01:21:41,160 GOING TO HAVE A COMPONENT WHERE 1892 01:21:41,160 --> 01:21:43,880 YOU SAY, LIKE WHAT ARE THE 1893 01:21:43,880 --> 01:21:46,440 ETHICAL ISSUES THE NEURAL ETHICS 1894 01:21:46,440 --> 01:21:48,160 ISSUES YOU CAN ANTICIPATE. 1895 01:21:48,160 --> 01:21:52,400 HAVE YOU TALKED TO CONSULTANTS 1896 01:21:52,400 --> 01:21:56,240 ON THIS AND IT SEEMS LIKE IN 1897 01:21:56,240 --> 01:21:57,840 THIS TYPE OF DESIGN AND OF 1898 01:21:57,840 --> 01:21:59,920 PROGRAM THAT CAN BE SOMETHING 1899 01:21:59,920 --> 01:22:02,040 THAT MAY BE PARTICULARLY 1900 01:22:02,040 --> 01:22:02,960 IMPORTANT. 1901 01:22:02,960 --> 01:22:06,600 IN TERMS OF WHERE THE 1902 01:22:06,600 --> 01:22:08,040 TECHNOLOGIES ARE GOING, 1903 01:22:08,040 --> 01:22:10,840 OBVIOUSLY THESE ARE GOING TO BE 1904 01:22:10,840 --> 01:22:11,120 CRITICAL. 1905 01:22:11,120 --> 01:22:14,000 I DO SUPPORT AND THIS IS A 1906 01:22:14,000 --> 01:22:17,200 FANTASTIC IDEA AND I'M VERY 1907 01:22:17,200 --> 01:22:18,320 SUPPORTIVE OF IT. 1908 01:22:18,320 --> 01:22:20,160 THE NEURAL CHEMICAL, I WANT TO 1909 01:22:20,160 --> 01:22:23,080 ECHO BRUCE'S IDEA AND FRANCES, 1910 01:22:23,080 --> 01:22:24,760 THINKING ABOUT CONNECTIONS 1911 01:22:24,760 --> 01:22:27,120 BETWEEN BRAIN AND OTHER BODILY 1912 01:22:27,120 --> 01:22:29,440 SYSTEMS ARE GOING TO BE REALLY 1913 01:22:29,440 --> 01:22:34,160 IMPORTANT COMING FROM NCCIH AND 1914 01:22:34,160 --> 01:22:35,960 ONE OF THE THINGS EMPHASIZED IS 1915 01:22:35,960 --> 01:22:38,640 THE WHOLE PERSON APPROACHES. 1916 01:22:38,640 --> 01:22:40,320 SO THINKING ABOUT KANG WE THINK 1917 01:22:40,320 --> 01:22:42,600 OF THE CONNECTIONS BETWEEN 1918 01:22:42,600 --> 01:22:44,240 THINGS LIKE THE BRAIN AND 1919 01:22:44,240 --> 01:22:46,040 HORMONAL SYSTEM AND THINK ABOUT 1920 01:22:46,040 --> 01:22:47,320 THE MUSCLES. 1921 01:22:47,320 --> 01:22:48,720 ARE THERE GOING TO BE SUPPORT 1922 01:22:48,720 --> 01:22:50,800 FOR TECHNOLOGY ENCOURAGING THOSE 1923 01:22:50,800 --> 01:22:52,960 KINDS OF TECHNOLOGIES AND THAT 1924 01:22:52,960 --> 01:22:56,840 MAY BE AT A VERY EARLY STAGE AND 1925 01:22:56,840 --> 01:22:58,960 THINKING BEYOND THE CNS SEEMS 1926 01:22:58,960 --> 01:23:00,360 LIKE AN IMPORTANT DIRECTION. 1927 01:23:00,360 --> 01:23:03,520 A QUESTION I HAD I WOULD LIKE TO 1928 01:23:03,520 --> 01:23:06,360 HEAR MORE ABOUT, IT SEEMED THERE 1929 01:23:06,360 --> 01:23:08,040 WAYS SLIGHT DISCONNECT BETWEEN 1930 01:23:08,040 --> 01:23:10,160 THE TECHNOLOGY AND METHODOLOGY 1931 01:23:10,160 --> 01:23:11,680 FOCUSSED APPROACHES FROM THE 1932 01:23:11,680 --> 01:23:15,760 ONES THAT ARE MORE ANALYTIC OR 1933 01:23:15,760 --> 01:23:17,040 SOFTWARE THAT MACHINE LEARNING 1934 01:23:17,040 --> 01:23:19,520 AND A.I. IN TERMS OF THAT IF YOU 1935 01:23:19,520 --> 01:23:23,040 HAD A PROJECT HOW IT WILL BE 1936 01:23:23,040 --> 01:23:24,320 PRIMARILY ON THAT DIRECTION WILL 1937 01:23:24,320 --> 01:23:27,960 NOT FIT IN WITH THIS PHASED 1938 01:23:27,960 --> 01:23:30,120 APPROACH AS WELL BECAUSE THE 1939 01:23:30,120 --> 01:23:34,840 USED CASE EXAMPLE YOU GAVE USING 1940 01:23:34,840 --> 01:23:36,120 MACHINE LEARNING ARE MODEL BASED 1941 01:23:36,120 --> 01:23:38,720 AND NEED NETWORKS TO IMPROVE 1942 01:23:38,720 --> 01:23:40,760 RESOLUTION FROM AS A SECONDARY 1943 01:23:40,760 --> 01:23:43,240 DATA ANALYSIS OF HUP. 1944 01:23:43,240 --> 01:23:44,760 IS THAT GOING TO FIT INTO THIS 1945 01:23:44,760 --> 01:23:46,520 AND HOW ARE YOU GOING TO 1946 01:23:46,520 --> 01:23:49,560 ENCOURAGE OR WILL THAT BE A 1947 01:23:49,560 --> 01:23:53,720 PIECE OR TECHNOLOGY AND SOFTWARE 1948 01:23:53,720 --> 01:23:55,160 ANALYTICS PART THAT WILL BE 1949 01:23:55,160 --> 01:23:56,840 INTEGRATED OR CAN PEOPLE HAVE 1950 01:23:56,840 --> 01:23:59,280 PROJECTS THEY ARE PROPOSING THAT 1951 01:23:59,280 --> 01:24:01,400 WILL BE FULLY NON-HARDWARE TYPES 1952 01:24:01,400 --> 01:24:04,600 OF PROJECT AND HOW WILL THAT FIT 1953 01:24:04,600 --> 01:24:05,680 IN WITH THIS AGREEMENT? 1954 01:24:05,680 --> 01:24:06,680 THAT'S SOMETHING I WAS THINKING 1955 01:24:06,680 --> 01:24:09,080 ABOUT AND WANT TO ECHO THE IDEA 1956 01:24:09,080 --> 01:24:11,880 OF THINKING CAREFULLY ABOUT 1957 01:24:11,880 --> 01:24:14,880 THESE GO/NO-GO MILESTONES AND 1958 01:24:14,880 --> 01:24:16,160 BEING CREATIVE ABOUT THAT I 1959 01:24:16,160 --> 01:24:18,360 THINK IT WILL BE IMPORTANT 1960 01:24:18,360 --> 01:24:20,520 BECAUSE HOW YOU GET FROM THE 1961 01:24:20,520 --> 01:24:23,360 DECISION OF THE PHASE 1 TO PHASE 1962 01:24:23,360 --> 01:24:25,000 2 AND THE CRITERIA USED IN 1963 01:24:25,000 --> 01:24:27,880 MAKING THE CLEAR TO THE 1964 01:24:27,880 --> 01:24:30,160 INVESTIGATORS IS ALSO USEFUL. 1965 01:24:30,160 --> 01:24:31,960 FINALLY, THESE TEAMS. 1966 01:24:31,960 --> 01:24:34,520 I LOVE THIS IDEA OF THE 1967 01:24:34,520 --> 01:24:36,080 CONSORTIUM. 1968 01:24:36,080 --> 01:24:39,760 ECHOING AGAIN, THE IDEA OF 1969 01:24:39,760 --> 01:24:40,600 PEOPLE THINKING ABOUT THE CASE 1970 01:24:40,600 --> 01:24:42,200 OF THESE AND HOW THEY MET ON THE 1971 01:24:42,200 --> 01:24:44,920 TEAM THAT YOU'RE THINKING ABOUT 1972 01:24:44,920 --> 01:24:46,320 WHAT ARE THESE TECHNOLOGIES 1973 01:24:46,320 --> 01:24:49,480 GEARED FOR IN TERMS OF THE KEY 1974 01:24:49,480 --> 01:24:50,920 NEUROSCIENCE THEORETICAL 1975 01:24:50,920 --> 01:24:52,520 QUESTIONS THEY'LL BE AIMED AT I 1976 01:24:52,520 --> 01:24:53,960 THINK WILL BE VERY IMPORTANT AS 1977 01:24:53,960 --> 01:24:58,200 WELL AND TO HAVE THAT CONSORTIUM 1978 01:24:58,200 --> 01:24:58,600 TO FACILITATE. 1979 01:24:58,600 --> 01:25:00,840 JUST WANT TO ECHO THIS IS GREAT 1980 01:25:00,840 --> 01:25:02,960 AND SUPPORTIVE OF IT AND THANK 1981 01:25:02,960 --> 01:25:04,680 YOU FOR BRINGING IT TO US. 1982 01:25:04,680 --> 01:25:06,080 I'LL STOP THERE. 1983 01:25:06,080 --> 01:25:08,760 >> THANK YOU, SO MUCH, TODD FOR 1984 01:25:08,760 --> 01:25:10,000 YOUR COMMENTS. 1985 01:25:10,000 --> 01:25:12,400 >> WE HAD A COMMENT IN THE CHAT. 1986 01:25:12,400 --> 01:25:14,600 WOULD YOU MIND IN MUTING 1987 01:25:14,600 --> 01:25:16,200 YOURSELF AND ASKING OR MAKING 1988 01:25:16,200 --> 01:25:18,160 THE SUGGESTION SO VIDEOCAST 1989 01:25:18,160 --> 01:25:19,960 PEOPLE CAN HEAR IT AS WELL? 1990 01:25:19,960 --> 01:25:22,920 >> YEAH, THE THOUGHT WAS A LOT 1991 01:25:22,920 --> 01:25:24,280 OF TIMES DWOE REQUEST OR TRY TO 1992 01:25:24,280 --> 01:25:27,360 GET INTO HUMAN WITHIN FIVE YEARS 1993 01:25:27,360 --> 01:25:30,320 OF A PROGRAM AND IT IS 1994 01:25:30,320 --> 01:25:31,040 AGGRESSIVE WITHOUT QUESTION BUT 1995 01:25:31,040 --> 01:25:33,720 SOMETIMES FIT LOOKS LIKE AS WE 1996 01:25:33,720 --> 01:25:35,320 GET -- IF IT LOOKS AS WE GET IN 1997 01:25:35,320 --> 01:25:36,560 THE PROGRAM TWO OR THREE YEARS 1998 01:25:36,560 --> 01:25:40,240 IN IT MAY NOT BE POSSIBLE, WE 1999 01:25:40,240 --> 01:25:43,320 THEN TRY TO ASK, CAN WE AT LEAST 2000 01:25:43,320 --> 01:25:45,520 GET INTO THE FDA WITH THE 2001 01:25:45,520 --> 01:25:48,200 PRE-SUB SO WE HAVE A LOT OF THE 2002 01:25:48,200 --> 01:25:50,360 SAFETY AND EFFICACIES STUDIES 2003 01:25:50,360 --> 01:25:52,040 DONE AND MAYBE NOT IN HUMAN YET 2004 01:25:52,040 --> 01:25:54,280 BUT A HUGE STEP FORWARD RATHER 2005 01:25:54,280 --> 01:25:58,320 THAN JUST DOING ANIMAL STUDIES 2006 01:25:58,320 --> 01:25:59,560 AND THE GRANT ENDS WITHOUT 2007 01:25:59,560 --> 01:26:01,640 HAVING GOT TO THE FDA AT ALL. 2008 01:26:01,640 --> 01:26:04,480 AND WHAT WE LEARNED IS HELPFUL 2009 01:26:04,480 --> 01:26:05,800 IS INFORMATIONAL MEETINGS WITH 2010 01:26:05,800 --> 01:26:10,280 THE FDA BEFORE PRE-SUBS BUT A 2011 01:26:10,280 --> 01:26:12,520 TIME FOR THE P.I. TO DISCUSS 2012 01:26:12,520 --> 01:26:14,360 WHAT THE PROGRAM IS AND THE TYPE 2013 01:26:14,360 --> 01:26:16,200 OF TECHNOLOGIES TO BE DEVELOPED. 2014 01:26:16,200 --> 01:26:18,160 SOME OF THAT STUFF THE FDA MAY 2015 01:26:18,160 --> 01:26:19,760 NOT HAVE HEARD OF OR BE READY 2016 01:26:19,760 --> 01:26:22,040 FOR YET SO HAVING AN EARLY 2017 01:26:22,040 --> 01:26:23,440 INDICATOR AS TO WHERE THE 2018 01:26:23,440 --> 01:26:25,520 RESEARCH MAY GO UNDER THE GRANT 2019 01:26:25,520 --> 01:26:27,760 CAN BE REALLY HELPFUL. 2020 01:26:27,760 --> 01:26:29,760 I WANTED TO SHARE THAT AND HAS 2021 01:26:29,760 --> 01:26:31,920 WORKED ALL WET ON THE DARPA 2022 01:26:31,920 --> 01:26:32,160 SIDE. 2023 01:26:32,160 --> 01:26:34,440 >> THANK YOU SO MUCH. 2024 01:26:34,440 --> 01:26:36,120 >> TED, DOW DID YOU HAVE A 2025 01:26:36,120 --> 01:26:37,800 COMMENT OR QUESTION? 2026 01:26:37,800 --> 01:26:39,920 >> YES, HI. 2027 01:26:39,920 --> 01:26:40,760 THIS IS VERY INTERESTING. 2028 01:26:40,760 --> 01:26:46,520 I WANTED TO ECHO THE COMMENTS ON 2029 01:26:46,520 --> 01:26:48,760 NEURO CHEMISTRY AND DEVELOPMENT. 2030 01:26:48,760 --> 01:26:51,240 THEY'RE BOTH IMPORTANT ISSUES TO 2031 01:26:51,240 --> 01:26:53,000 HIGHLIGHT AND SOMETHING THAT'S 2032 01:26:53,000 --> 01:27:02,760 NOT JUST FROM NINDS BUT DIRECTOR 2033 01:27:02,760 --> 01:27:06,680 AND NEURO CHEMICALLY IT'S 2034 01:27:06,680 --> 01:27:12,760 INTERESTING HOW MUCH PHYTO 2035 01:27:12,760 --> 01:27:15,360 PHOTOMETRY HAVE INFLUENCED AND I 2036 01:27:15,360 --> 01:27:16,080 THINK IT'S IMPORTANT. 2037 01:27:16,080 --> 01:27:19,960 I ALSO WANTED TO COMMENT ON THE 2038 01:27:19,960 --> 01:27:21,680 FIVE-YEAR DELIVERY THINGS. 2039 01:27:21,680 --> 01:27:24,160 OTHER ORGANIZATIONS DO THIS 2040 01:27:24,160 --> 01:27:25,600 QUITE DIFFERENTLY WHERE DARPA, 2041 01:27:25,600 --> 01:27:26,480 FOR EXAMPLE, WOULD START WITH A 2042 01:27:26,480 --> 01:27:28,440 GROUP OF INVESTIGATORS AT THE 2043 01:27:28,440 --> 01:27:29,840 BEGINNING AND MAYBE END WITH 2044 01:27:29,840 --> 01:27:32,560 ONLY ONE OR TWO OF THEM NOT ALL 2045 01:27:32,560 --> 01:27:35,520 SIX OR SEVEN. 2046 01:27:35,520 --> 01:27:38,200 NIH DOESN'T EXACTLY WANT TO DO 2047 01:27:38,200 --> 01:27:39,400 THAT BUT THEY'RE OBVIOUSLY MORE 2048 01:27:39,400 --> 01:27:42,800 FOCUSSED ON OUTCOME AND YOU GET 2049 01:27:42,800 --> 01:27:45,600 KICKED OFF THE ISLAND IF YOU'RE 2050 01:27:45,600 --> 01:27:46,360 NOT DOING THE THING. 2051 01:27:46,360 --> 01:27:47,920 THERE'S MORE AGGRESSIVE WAYS TO 2052 01:27:47,920 --> 01:27:50,120 MAKE A DELIVERY HERE IF THAT'S 2053 01:27:50,120 --> 01:27:51,520 WHAT YOU'RE TRYING TO DO. 2054 01:27:51,520 --> 01:27:52,880 LASTLY, I WANT TO MAKE A GENERAL 2055 01:27:52,880 --> 01:27:56,000 POINT I MADE WITH THE ORIGINAL 2056 01:27:56,000 --> 01:27:59,520 CONNECTOME PROJECT DECADE AGO OR 2057 01:27:59,520 --> 01:28:03,360 15 YEARS AGO AND THAT IS A 2058 01:28:03,360 --> 01:28:04,400 FUNDAMENTAL HALLMARK OF THE 2059 01:28:04,400 --> 01:28:06,400 INFORMATION SYSTEM IS IT'S 2060 01:28:06,400 --> 01:28:06,720 PLASTICITY. 2061 01:28:06,720 --> 01:28:08,600 IT WILL DRIVE OUR ABILITY TO 2062 01:28:08,600 --> 01:28:10,000 RESPOND TO EXPERIENCE AND 2063 01:28:10,000 --> 01:28:11,760 REMEMBER EXPERIENCE AND WHAT 2064 01:28:11,760 --> 01:28:13,160 DRIVES A LOT OF DISEASE AND 2065 01:28:13,160 --> 01:28:14,720 COMPENSATION BECAUSE OF THAT 2066 01:28:14,720 --> 01:28:16,080 PLASTICITY CAN HELP PEOPLE 2067 01:28:16,080 --> 01:28:18,080 FUNCTION BUT CAN ALSO MAKE THEM 2068 01:28:18,080 --> 01:28:18,640 WORSE OR WORSE IN DIFFERENT 2069 01:28:18,640 --> 01:28:22,040 WAYS. 2070 01:28:22,040 --> 01:28:24,200 SO I JUST WANT TO UNDER SCORE 2071 01:28:24,200 --> 01:28:25,720 HOW MUCH PLASTICITY IS INVOLVED 2072 01:28:25,720 --> 01:28:26,840 IN THESE THINGS. 2073 01:28:26,840 --> 01:28:28,040 IT'S ONE THING TO KNOW HOW THESE 2074 01:28:28,040 --> 01:28:29,960 THINGS ARE CONNECTED BUT IF WE 2075 01:28:29,960 --> 01:28:34,360 GO TO SLEEP AND WAKE UP AGAIN, 2076 01:28:34,360 --> 01:28:35,760 THEY'LL CHANGE. 2077 01:28:35,760 --> 01:28:37,680 AND I REMEMBER COMMENTING ON A 2078 01:28:37,680 --> 01:28:38,960 MICROSCALE AT HARVARD WHERE THEY 2079 01:28:38,960 --> 01:28:41,680 WERE COUNTING SYNAPSES WITH 2080 01:28:41,680 --> 01:28:44,160 EVERY BIOLOGY MAJOR WAS COUNTING 2081 01:28:44,160 --> 01:28:45,680 SYNAPSES IN THE MOUSE CORTEX AND 2082 01:28:45,680 --> 01:28:47,120 IF THE MOUSE FELL ASLEEP OR 2083 01:28:47,120 --> 01:28:50,480 CHANGED IT WOULD HAVE CHANGED 2084 01:28:50,480 --> 01:28:55,440 AND THINKING ABOUT PLASTICITY IS 2085 01:28:55,440 --> 01:29:00,720 AN IMPORTANT CONCEPT AND WE MAY 2086 01:29:00,720 --> 01:29:03,080 KNOW HOW IT CHANGES AND THAT IS 2087 01:29:03,080 --> 01:29:05,400 VERY IMPORTANT. 2088 01:29:05,400 --> 01:29:07,880 TO ME WE LOSE TRACK OF THAT 2089 01:29:07,880 --> 01:29:09,800 PLASTICITY AND DO IN THE GENETIC 2090 01:29:09,800 --> 01:29:11,400 BASIS OF BRAIN DISORDERS BECAUSE 2091 01:29:11,400 --> 01:29:13,560 WE DON'T THINK HOW THAT'S READ 2092 01:29:13,560 --> 01:29:15,560 OUT, WE THINK OF WHAT IT IS. 2093 01:29:15,560 --> 01:29:17,960 THAT'S A SOAPBOX OF MINE I 2094 01:29:17,960 --> 01:29:19,240 THOUGHT I WOULD JUMP ON. 2095 01:29:19,240 --> 01:29:20,680 I HOPE THAT'S OKAY. 2096 01:29:20,680 --> 01:29:24,360 >> THANK YOU SO MUCH FOR YOUR 2097 01:29:24,360 --> 01:29:24,960 COMMENTS, TED. 2098 01:29:24,960 --> 01:29:26,360 >> FRANCES. 2099 01:29:26,360 --> 01:29:29,160 >> THE ISSUE OF PLASTICITY I 2100 01:29:29,160 --> 01:29:30,480 REMEMBER I CAME OUT WHEN JOHN 2101 01:29:30,480 --> 01:29:33,040 AND I HAD OUR ONE-ON-ONE CALL. 2102 01:29:33,040 --> 01:29:34,960 THERE'S NO OTHER ORGAN SYSTEM 2103 01:29:34,960 --> 01:29:36,760 WHERE THE CELLS ARE CHANGING BY 2104 01:29:36,760 --> 01:29:37,960 THE MICROSECOND. 2105 01:29:37,960 --> 01:29:40,280 WHAT IS AN INTERESTING THING TO 2106 01:29:40,280 --> 01:29:47,920 CAPTURE, WHICH I DIDN'T MENTION 2107 01:29:47,920 --> 01:29:50,440 THIS, TRYING TO MAP AT WHAT 2108 01:29:50,440 --> 01:29:55,040 LEVEL AT CONNECTIVITY MAP IS 2109 01:29:55,040 --> 01:29:58,320 THERE A HIGH DEGREE OF CHANGE IN 2110 01:29:58,320 --> 01:29:59,920 THE MILLISECOND VERSUS YEARS OR 2111 01:29:59,920 --> 01:30:00,160 NONE. 2112 01:30:00,160 --> 01:30:01,880 AND GETTING A SENSE OF THAT 2113 01:30:01,880 --> 01:30:05,600 RANGE IS PROBABLY GOING TO BE 2114 01:30:05,600 --> 01:30:07,200 DIFFERENT BETWEEN SPECIES AND 2115 01:30:07,200 --> 01:30:08,040 CERTAINLY BETWEEN OUR BRAIN 2116 01:30:08,040 --> 01:30:11,920 AREAS BUT COULD BE A FASCINATING 2117 01:30:11,920 --> 01:30:15,960 OUTSIDE OF THE BOX ENDEAVOR TO 2118 01:30:15,960 --> 01:30:19,960 THINK ABOUT IN SOME WAY FOR SOME 2119 01:30:19,960 --> 01:30:22,240 GROUPS IN INTERPRETING HUMAN 2120 01:30:22,240 --> 01:30:23,240 BEHAVIOR AND WHAT IS REVERSIBLE 2121 01:30:23,240 --> 01:30:23,960 VERSUS WHAT IS NOT. 2122 01:30:23,960 --> 01:30:26,880 >> THANK YOU SO MUCH. 2123 01:30:26,880 --> 01:30:28,720 >> I'LL JUMP IN AND SAY THE 2124 01:30:28,720 --> 01:30:30,280 COMMENT ABOUT PLASTICITY SAY 2125 01:30:30,280 --> 01:30:30,680 GREAT COMMENT. 2126 01:30:30,680 --> 01:30:33,360 I COMPLETELY AGREE AND REINFORCE 2127 01:30:33,360 --> 01:30:34,960 THE BROAD DEFINITION OF WHAT 2128 01:30:34,960 --> 01:30:40,720 WE'RE AFTER HERE WHEN WE TALK 2129 01:30:40,720 --> 01:30:41,480 ABOUT BRAIN FUNCTION. 2130 01:30:41,480 --> 01:30:43,200 THAT'S NOT A SINGULAR THING SO 2131 01:30:43,200 --> 01:30:45,320 MAKING CLEAR WHEN WE USE THAT WE 2132 01:30:45,320 --> 01:30:46,920 DON'T MEAN NECESSARILY FUNCTION 2133 01:30:46,920 --> 01:30:50,840 IN THE WAY SAY SOMEBODY DOING 2134 01:30:50,840 --> 01:30:54,120 THAT DOES BUT MAY PART OF IT BUT 2135 01:30:54,120 --> 01:30:55,640 INCORPORATES ALL THE LINK 2136 01:30:55,640 --> 01:30:59,520 ELEMENTS INCLUDING MEASUREMENTS 2137 01:30:59,520 --> 01:31:02,800 OF PLASTICITY AND NEUROCHEMICAL 2138 01:31:02,800 --> 01:31:04,880 CHANGES AND OVER THE TIMES OF 2139 01:31:04,880 --> 01:31:06,080 RANGE OF TIME FRAMES FRANCES 2140 01:31:06,080 --> 01:31:07,360 TALKED ABOUT ALL RELEVANT NOR 2141 01:31:07,360 --> 01:31:09,440 FUNCTION OF THE BRAIN. 2142 01:31:09,440 --> 01:31:13,600 WE WANT TO BE CLEAR THAT WE'RE 2143 01:31:13,600 --> 01:31:15,880 USING WHAT I CAUGHT BIG F 2144 01:31:15,880 --> 01:31:17,880 FUNCTIONAL IMAGING NOT LITTLE F 2145 01:31:17,880 --> 01:31:31,080 FUNCTIONAL IMAGING. 2146 01:31:31,080 --> 01:31:33,840 >> THERE'S ALREADY A RO1 OUT 2147 01:31:33,840 --> 01:31:36,520 THERE ABOUT NEURO IMAGING 2148 01:31:36,520 --> 01:31:38,680 RESEARCH AND PORTABLE MRIs 2149 01:31:38,680 --> 01:31:42,880 ALREADY HAS A NEUROETHICS MORE 2150 01:31:42,880 --> 01:31:44,680 INTERACTIONS WITH THE 2151 01:31:44,680 --> 01:31:47,920 NEUROETHICS FOLKS AND THE NEWG 2152 01:31:47,920 --> 01:31:49,440 AND THE NEURO ETHICS GROUP WOULD 2153 01:31:49,440 --> 01:31:53,840 BE EXCITED ABOUT THE 2154 01:31:53,840 --> 01:31:55,280 INTERACTIONS. 2155 01:31:55,280 --> 01:31:59,280 >> WE DID ONE AND WE HAD A 2156 01:31:59,280 --> 01:32:02,480 RECIPIENT OF THE SUPPLEMENTAL 2157 01:32:02,480 --> 01:32:06,880 AWARD FROM THE UL1 GRANT AND 2158 01:32:06,880 --> 01:32:08,920 STARTED A TOOL FOR THAT ONE. 2159 01:32:08,920 --> 01:32:10,920 WE DO KEEP IN MIND AND WILL 2160 01:32:10,920 --> 01:32:12,400 CONTINUE DOING THAT IN THE 2161 01:32:12,400 --> 01:32:12,640 FUTURE. 2162 01:32:12,640 --> 01:32:21,880 IT'S A VERY IMPORTANT TOPIC. 2163 01:32:21,880 --> 01:32:24,560 >> -- ALSO TO THE NEURO 2164 01:32:24,560 --> 01:32:28,000 CHEMICAL SIDE THERE'S ONGOING 2165 01:32:28,000 --> 01:32:29,000 DISCUSSION ABOUT HOW TO SEPARATE 2166 01:32:29,000 --> 01:32:29,880 THAT. 2167 01:32:29,880 --> 01:32:35,480 IT'S A HUGE TOPIC AND 2168 01:32:35,480 --> 01:32:37,680 PRELIMINARY FROM AN 2169 01:32:37,680 --> 01:32:38,520 IMPLEMENTATION RESEARCH AND 2170 01:32:38,520 --> 01:32:39,960 SAFETY AND THERE'S A HUGE 2171 01:32:39,960 --> 01:32:44,880 DISCUSSION AND HOPE THERE'S NEW 2172 01:32:44,880 --> 01:32:46,000 OPPORTUNITY IN THE FUTURE AND 2173 01:32:46,000 --> 01:32:53,880 WITH OTHER PARTS IS A BIGGER 2174 01:32:53,880 --> 01:32:54,600 CHALLENGE. 2175 01:32:54,600 --> 01:32:56,440 NOW YOU WANT TO INVESTIGATE 2176 01:32:56,440 --> 01:32:58,160 OUTSIDE THE BRAIN AND HAVEN'T 2177 01:32:58,160 --> 01:33:00,080 DONE MUCH DEVELOPMENT IN THAT 2178 01:33:00,080 --> 01:33:00,880 IMAGING. 2179 01:33:00,880 --> 01:33:02,440 IT'S A NEW OPPORTUNITY AND 2180 01:33:02,440 --> 01:33:04,080 BROADER AND LARGER SCALE AND 2181 01:33:04,080 --> 01:33:15,080 TRULY EXCITING. 2182 01:33:15,080 --> 01:33:16,520 >> I'M NOT SEEING ANY OTHER 2183 01:33:16,520 --> 01:33:17,120 HANDS RAISED. 2184 01:33:17,120 --> 01:33:19,080 CLEARLY A LOT OF ENTHUSIASM FOR 2185 01:33:19,080 --> 01:33:21,640 THIS CONCEPT AND SOME ADDITIONAL 2186 01:33:21,640 --> 01:33:23,160 THINGS TO THINK ABOUT. 2187 01:33:23,160 --> 01:33:24,480 THANK YOU ALL. 2188 01:33:24,480 --> 01:33:27,080 I'M GOING ASSUME THE GENERAL 2189 01:33:27,080 --> 01:33:28,880 FEELING IS THIS IS A GOOD 2190 01:33:28,880 --> 01:33:29,880 CONCEPT FOR BRAIN TO BE 2191 01:33:29,880 --> 01:33:34,080 SUPPORTING AS WE MOVE FORWARD. 2192 01:33:34,080 --> 01:33:37,160 ARE THERE ANY OBJECTIONS, SPEAK 2193 01:33:37,160 --> 01:33:37,640 NOW? 2194 01:33:37,640 --> 01:33:38,680 WELL, THANK YOU ALL VERY MUCH. 2195 01:33:38,680 --> 01:33:41,880 AGAIN, THIS HAS BEEN A VERY RICH 2196 01:33:41,880 --> 01:33:45,240 CONVERSATION AND I THINK ALL OF 2197 01:33:45,240 --> 01:33:47,960 YOUR INPUT IS REALLY HELPFUL. 2198 01:33:47,960 --> 01:33:49,680 ALSO, I WANTED TO REMIND PEOPLE 2199 01:33:49,680 --> 01:33:52,600 THE NEUROETHICS WORKING GROUP 2200 01:33:52,600 --> 01:33:53,680 MEETING FROM YESTERDAY WILL BE 2201 01:33:53,680 --> 01:33:55,960 ON THE NIH VIDEOCAST SIDE AND 2202 01:33:55,960 --> 01:33:57,760 ARCHIVED THERE SO FOR THOSE 2203 01:33:57,760 --> 01:33:59,520 INTERESTED IN TRYING TO PUT IN 2204 01:33:59,520 --> 01:34:00,560 ADDITIONAL IDEAS OF HOW THAT 2205 01:34:00,560 --> 01:34:03,040 GROUP CAN MOVE FORWARD, THAT 2206 01:34:03,040 --> 01:34:03,960 WILL BE AVAILABLE IF YOU MISSED 2207 01:34:03,960 --> 01:34:06,440 IT YESTERDAY. 2208 01:34:06,440 --> 01:34:09,280 >> I WANT TO THANK YOU ALL FOR 2209 01:34:09,280 --> 01:34:10,440 YOUR GREAT COMMENTS. 2210 01:34:10,440 --> 01:34:12,400 I WILL WRITE MY NOTES AND TAKE 2211 01:34:12,400 --> 01:34:14,000 THEM INTO FULL CONSIDERATION AND 2212 01:34:14,000 --> 01:34:14,360 IMPLEMENTATION. 2213 01:34:14,360 --> 01:34:18,680 THANK YOU AGAIN. 2214 01:34:18,680 --> 01:34:21,080 >> SO WE ARE READY FOR A BREAK 2215 01:34:21,080 --> 01:34:23,160 FOR LUNCH BREAK OR SOME KIND OF 2216 01:34:23,160 --> 01:34:23,360 BREAK. 2217 01:34:23,360 --> 01:34:25,480 WE'LL BE RESUMING AT 2:30 AND 2218 01:34:25,480 --> 01:34:27,920 THAT WILL BE THE CLOSED SESSION 2219 01:34:27,920 --> 01:34:29,920 AND THAT WILL AGAIN BE WITH JUST 2220 01:34:29,920 --> 01:34:31,680 THE COUNCIL MEMBERS AND FEDERAL 2221 01:34:31,680 --> 01:34:31,920 EMPLOYEES. 2222 01:34:31,920 --> 01:34:33,880 SO LOOK FORWARD TO TALKING TO 2223 01:34:33,880 --> 01:34:35,920 YOU THEN AND THERE IS A SEPARATE 2224 01:34:35,920 --> 01:34:36,880 ZOOM LINK TO GET ON TO THE 2225 01:34:36,880 --> 01:34:39,000 CLOSED SESSION. 2226 01:34:39,000 --> 01:34:42,000 >> THANK YOU ALL FOR YOUR GREAT 2227 01:34:42,000 --> 01:34:42,440 COMMENTS. 2228 01:34:42,440 --> 01:34:45,440 WE WILL DEFINITELY TAKE THESE 2229 01:34:45,440 --> 01:34:48,080 UNDER CAREFUL CONSIDERATION AND 2230 01:34:48,080 --> 01:34:51,320 FOR THE COUNCIL MEMBERS WORKING 2231 01:34:51,320 --> 01:34:53,920 GROUP WE'LL SEE YOU IN HALF AN 2232 01:34:53,920 --> 01:34:58,040 HOUR OR SO? 2233 01:34:58,040 --> 01:34:59,200 MORE? 2234 01:34:59,200 --> 01:34:59,520 2:30. 2235 01:34:59,520 --> 01:35:01,280 >> 40 MINUTES. 2236 01:35:01,280 --> 01:35:01,520 >> GREAT. 2237 01:35:01,520 --> 00:00:00,000 THANKS SO MUCH.