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00:00:05,960 --> 00:00:10,880
>> I'D LIKE TO CALL THE 124th 

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MEETING TO THE DIRECTOR OPEN AND

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THAT'S AS CLOSE AS I CAN GET TO 

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00:00:22,600 --> 00:00:28,640
A GAVEL AND IT'S SAFER.

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00:00:28,640 --> 00:00:31,080
I WANT TO THANK YOU FOR TAKING 

6
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TIME FROM BUSY SCHEDULES TO BE 

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WITH US TODAY AND TOMORROW.

8
00:00:34,640 --> 00:00:38,120
THE MEETING WILL BE HELD TODAY 

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FROM 10:00 A.M. TO ABOUT 4:15 

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P.M. EASTERN TIME.

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THEM AGAIN TOMORROW 10:00 A.M. 

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TO 2:45 EASTERN TIME.

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00:00:53,600 --> 00:00:55,400
ON BOTH DAYS THE MEETING WILL BE

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RECORDED.

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THE MEETING IS OPEN TO THE 

16
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PUBLIC AND CAN BE ACCESSED BY 

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THE VIDEOCAST.

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I KNOW YOU APPRECIATE HOW FULL 

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THE NEXT COUPLE OF DAYS ARE 

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GOING TO BE AND WE'LL DO OUR 

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VERY BEST TO STAY ON TIME I'VE 

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ASKED DR. SCHWETZ TO HELP KEEP 

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US ON TIME AND INHERITED WHAT I 

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USED SO MANY YEARS.

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TARA.

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>> IT'S A VIRTUAL BELL.

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THIS IS WHAT IT WILL SOUND LIKE.

28
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HOPEFULLY IT WILL COME THROUGH.

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THE MEETING IS OPEN TO THE 

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PUBLIC INCLUDING MEMBERS OF THE 

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PRESS AND IT IS BEING WEBCAST 

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AND STREAMING LIVE RIGHT NOW.

33
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MEETING PRESENTATIONS AND ANY 

34
00:02:07,480 --> 00:02:09,880
SUPPLEMENTAL MATERIAL WILL BE 

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POSTED ON THE ACD WEBSITE AT THE

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TIME OF EACH PRESENTATION.

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AND THE MEETING WAS ANNOUNCED IN

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THE FEDERAL REGISTER ON MAY 13, 

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2022.

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WE DID RECEIVE PUBLIC COMMENT 

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AND THE MEMBERS CAN SHARE IT ON 

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THE FILE SITE.

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ACD MEMBERS AND PRESENTERS ARE 

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USING THE ZOOM APPLICATION FOR 

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OUR MEETING TODAY AND TOMORROW.

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YOU CAN USE THE CHAT FEATURE AS 

47
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QUESTION ASKED OR MAKE A COMMENT

48
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OR QUESTION.

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WHEN AN ACD MEMBER DOES WISH TO 

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MAKE A COMMENT, WE ASK YOU 

51
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PLEASE TURN ON YOUR VIDEO AND 

52
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MAKE SURE THAT YOU ARE UNMUTED 

53
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SO THAT OUR REPORTING CAN 

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CAPTURE THAT.

55
00:03:05,360 --> 00:03:07,680
THAT'S OVER FOR THE LOGISTICS SO

56
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BACK TO YOU.

57
00:03:08,640 --> 00:03:10,320
>> LET ME PREVIEW THE
AGENDA WE 

58
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HAVE OVER THE NEXT COUPLE OF 

59
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DAYS.

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00:03:13,640 --> 00:03:17,920
WE'LL BEGIN WITH A REPORT FROM 

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ME.

62
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THAT WILL INCLUDE BUDGET UPDATES

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FROM NEIL SHAPIRO AND A SHORT 

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BREAK AT 11:30 A.M. AND THEN 

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TARA WILL GIVE A PRESENTATION ON

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ARPA-H TO UPDATE PEOPLE AS TO 

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WHERE PER AND THAT WILL BE 

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FOLLOWED BY DISCUSSION.

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00:03:41,800 --> 00:03:47,840
WE'LL DO A QUICK BREAK AT 12:45.

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WE'LL HAVE A PRESENTATION FROM 

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00:03:53,080 --> 00:03:57,160
DR. FAUCI FOLLOWED BY 

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PRESENTATIONS BY DR. KOROSHETZ 

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AND BIANCHI ON RECOVER AND 

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UPDATES ON COVID-19 IN CHILDREN 

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00:04:03,840 --> 00:04:08,640
AND PEOPLE OF REPRODUCTIVE AGE 

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00:04:08,640 --> 00:04:08,960
RESPECTIVELY.

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WE'LL THEN DO A FINAL BREAK FOR 

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THE DAY AT AROUND 3:30 AND AT 

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00:04:18,280 --> 00:04:20,800
3:45 DR. MIKE LAUER WILL DO AN 

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00:04:20,800 --> 00:04:26,440
UPDATE ON THE RIGOR AND ANIMAL 

81
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USE SO MANY PARTICIPATED ON.

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AT THE END OF THE DAY WE'LL HAVE

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A FEW QUICK CLOSING COMMENTS AND

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ADJOURN.

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00:04:34,320 --> 00:04:36,560
TOMORROW, JUNE 10, WE WILL LEAD 

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OFF WITH A DISCUSSION BY 

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00:04:39,840 --> 00:04:43,520
DR. MARIE BERNARD ON OUR 

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DIVERSITY, EQUITY, INCLUSION AND

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00:04:47,720 --> 00:04:48,800
ACCESSIBILITY STRATEGIC 

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PLANNING.

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00:04:49,080 --> 00:04:52,640
WE'LL THEN HAVE WHAT HAS BECOME 

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00:04:52,640 --> 00:04:54,840
A TRADITION OVER THE LAST 

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00:04:54,840 --> 00:04:57,080
SEVERAL MEETING AN UPDATE FROM 

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00:04:57,080 --> 00:05:00,400
OUR UNITE GROUP AND EACH OF THE 

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FIVE CO-CHAIRS AND THOSE FIVE 

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00:05:03,240 --> 00:05:04,640
WORK STREAMS WILL HAVE A READOUT

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00:05:04,640 --> 00:05:08,040
AND WE'LL HAVE TIME FOR GENERAL 

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DISCUSSION.

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THERE WILL BE A BREAK AROUND 

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12:30.

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00:05:10,720 --> 00:05:15,960
WE'LL GET BACK TO DEATOGETHER AN

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00:05:15,960 --> 00:05:18,600
FOR THE FINAL PRESENTATIONS ON 

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NIH DATA SHARING POLICY AND THE 

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00:05:22,840 --> 00:05:23,440
SUPPORTIVE INFRASTRUCTURE 

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00:05:23,440 --> 00:05:27,480
EFFORTS AND THAT WILL BE 

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00:05:27,480 --> 00:05:32,000
PRESENTED BY DOCTORS JORGENSON, 

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LAUER AND GREGURICK AND END UP 

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WITH CLOSING COMMENTS AND 

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ADJOURN.

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A LOT OF MATERIAL TO COVER IN A 

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SHORT PERIOD OF TIME.

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THE TENDENCY IS TO SIT BACK AND 

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JUST LISTEN BUT AS THE MEMBERS 

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00:05:49,280 --> 00:05:54,240
OF THE COMMITTEE WHO HAVE BEEN 

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00:05:54,240 --> 00:05:57,640
ON FOR A WHILE IT'S A MUCH 

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BETTER MEETING IF THE COUNCIL 

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MEMBERS ENGAGE.

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PLEASE, DON'T BE PASSIVE.

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THERE'S A FEW I DON'T HAVE TO 

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SAY THAT TO IN GENERAL I KNOW 

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BUT DON'T BE PASSIVE AND IF YOU 

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HAVE A QUESTION AS YOU'RE GOING 

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ALONG IN A PRESENTATION -- I 

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ASSUME THE CHAT FUNCTION IS 

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ENABLED TARA.

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>> THAT'S RIGHT.

127
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PUT YOUR QUESTION IN THE CHAT 

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BOX AND IF THERE'S A LOGICAL 

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BREAK TO THE PRESENTATION, TARA 

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OR I WILL ACKNOWLEDGE YOU, IF 

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NOT IT RECORDS THE QUESTION AND 

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AT THE END OF THE PRESENTATION 

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00:06:39,600 --> 00:06:47,120
WE'LL CIRCLE BACK AND IT KEEPS 

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THE THOUGHT FRESH BECAUSE YOU'VE

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CAPTURED IT.

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PLEASE, LET'S MAKE THIS AS 

137
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INTERACTIVE AS POSSIBLE AND 

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AGAIN AS THE COUNCIL MEMBERS WHO

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SERVED BEFORE KNOW, AT THE END 

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OF THE REPORT COUNCIL MEMBERS 

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CAN BRING UP ANY TOPIC THEY WISH

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AND I OR THE TEAM WILL DO OUR 

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BEST TO ANSWER WHATEVER THE 

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00:07:19,680 --> 00:07:20,880
QUESTION IS OR FOR ANY COMMENT 

145
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YOU MAY HAVE.

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SO BEFORE WE GET STARTED WITH 

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THE REST OF THE AGENDA, IF I CAN

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00:07:28,960 --> 00:07:39,240
HAVE THE SLIDE.

149
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I THOUGHT IT WOULD BE IMPORTANT 

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TO ACKNOWLEDGE THE PASSING OF 

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00:07:46,160 --> 00:07:47,200
MR. JOHN PORT.

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I'M SURE MANY HAVE HEARD THE 

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NEWS MR. PORTER IN THE HEALTH 

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AND HUMAN SERVICES AND EDUCATION

155
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AND RELATED ACTIONS THAT OVERSAW

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NIH FUNDING PASSED AWAY LAST 

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WEEK AFTER AN EXTENDED ILLNESS.

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MR. PORTER WAS ONE OF THE 

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00:08:10,320 --> 00:08:11,400
GREATEST CHAMPIONS FOR NIH IN 

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THE HISTORY OF THE AGENCY.

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HE AND HIS COLLEAGUES IN THE 

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HOUSE, FOLKS LIKE MR. DAVID OBE 

163
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AND MR. TOM HARKIN AND 

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MR. SPECTER, WORKED TO DOUBLE 

165
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THE NIH BUDGET IN FIVE YEARS 

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FROM THE PERIOD FROM 1998 TO 

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2003.

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IT WAS A REMARKABLE LEGISLATIVE 

169
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ACHIEVEMENT AND ENABLED 

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BIOMEDICAL RESEARCH TO MOVE 

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FORWARD AT AN UNPRECEDENTED 

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PACE.

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THEN AGAIN AS I'M SURE MANY OF 

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YOU KNOW, AFTER HIS CAREER IN 

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CONGRESS, MR. PORTER CONTINUED 

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TO WORK HARD FOR INCREASED 

177
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INVESTMENTS IN BIOMEDICAL 

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RESEARCH AND ALWAYS HAD A FOCUS 

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ON HOW THESE ADVANCED WOULD HELP

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OVERCOME DISEASE, ALLEVIATE 

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SUFFERING AND IMPROVE PEOPLE'S 

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HEALTH.

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00:09:08,360 --> 00:09:12,400
NIH HAS LOST ONE OF OUR MOST 

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STALWART HEROES AND WE'LL 

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00:09:13,400 --> 00:09:17,040
FOREVER BE IN HIS DEBT.

186
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OUR HEARTS GO OUT TO HIS WIFE, 

187
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AMY WHO  LEADING AT THIS TIME 

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AND WE A BUILDING CALLED THE 

189
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JOHN EDWARD PORTER NEUROSCIENCE 

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CENTER WHICH WE DEDICATED IN 

191
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20

192
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2014.

193
00:09:45,480 --> 00:09:48,880
THAT BUILDING WAS SOMEWHAT OF AN

194
00:09:48,880 --> 00:09:50,880
EXPERIMENT WHERE WE HAD AN 

195
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INDIVIDUAL CENTER OCCUPY THE 

196
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SPACE, MULTIPLE INSTITUTES AND 

197
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CENTERS OCCUPY THE SPACE WITH 

198
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SHARED GOVERNANCE, COME CORES 

199
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AND PLACE TO HAVE A CUP OF 

200
00:10:08,640 --> 00:10:08,880
COFFEE.

201
00:10:08,880 --> 00:10:11,160
THAT HAS SINCE BEEN REPLICATED 

202
00:10:11,160 --> 00:10:13,120
IN OTHER BUILDINGS HAVING PROVED

203
00:10:13,120 --> 00:10:15,720
TO BE SO SUCCESSFUL AND NO DOUBT

204
00:10:15,720 --> 00:10:17,400
THE SCIENCE THAT WAS CONDUCTED 

205
00:10:17,400 --> 00:10:19,800
IN THOSE WALLS WILL HELP CARRY 

206
00:10:19,800 --> 00:10:28,640
OUT HIS EXTRAORDINARY LEGACY.

207
00:10:28,640 --> 00:10:38,800
SO OKAY.

208
00:10:40,120 --> 00:10:43,360
HERE'S MANY OF THE APPOINTMENTS 

209
00:10:43,360 --> 00:10:44,960
AND DEPARTURES SINCE WE LAST 

210
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MET, TALK ABOUT A FEW AWARDS AND

211
00:10:48,840 --> 00:10:52,640
HONOREES, NIH IS FORTUNATE TO 

212
00:10:52,640 --> 00:11:00,400
HAVE.

213
00:11:00,400 --> 00:11:03,920
WE'LL GET BUDGET UPDATES AND 

214
00:11:03,920 --> 00:11:08,440
TALK ABOUT INITIATIVES AND A 

215
00:11:08,440 --> 00:11:12,280
SAMPLING, OBVIOUSLY AND PROVIDE 

216
00:11:12,280 --> 00:11:14,880
AN UPDATE ON OUR EFFORTS TO 

217
00:11:14,880 --> 00:11:19,720
ADDRESS SEXUAL HARASSMENT AND 

218
00:11:19,720 --> 00:11:26,520
SEND WITH -- END WITH A COUPLE 

219
00:11:26,520 --> 00:11:28,160
THINGS THAT KEEP ME UP AT NIGHT 

220
00:11:28,160 --> 00:11:30,560
AND PUT THEM THERE AS A WAY TO 

221
00:11:30,560 --> 00:11:32,360
PROMPT DISCUSSION BY THE COUNCIL

222
00:11:32,360 --> 00:11:40,560
ON TWO THE DIFFERENT TOPICS.

223
00:11:40,560 --> 00:11:42,080
I LOOK FORWARD TO HEARING YOUR 

224
00:11:42,080 --> 00:11:43,320
THOUGHTS ON THESE TOPICS WHEN WE

225
00:11:43,320 --> 00:11:45,120
GET TO THAT.

226
00:11:45,120 --> 00:11:55,680
SO IF I CAN HAVE THE NEXT SLIDE.

227
00:11:56,560 --> 00:11:59,880
SO THIS IS A PICTURE OF THE 

228
00:11:59,880 --> 00:12:02,360
DIRECTOR PRIOR TO THE LAST 

229
00:12:02,360 --> 00:12:03,840
MEETING.

230
00:12:03,840 --> 00:12:06,080
AND AS CAN SEE BY WHO'S THERE 

231
00:12:06,080 --> 00:12:11,680
AND WHO'S NOT THERE ANYMORE, WE 

232
00:12:11,680 --> 00:12:14,520
HAVE A NUMBER OF CHANGES.

233
00:12:14,520 --> 00:12:17,760
MOST OBVIOUS IS FRANCIS STEPPING

234
00:12:17,760 --> 00:12:18,760
DOWN AS NIH DIRECTOR AT THE END 

235
00:12:18,760 --> 00:12:22,960
OF THE CALENDAR YEAR.

236
00:12:22,960 --> 00:12:29,080
TWO MEMBERS OF THE ACD ARE 

237
00:12:29,080 --> 00:12:32,400
ROTATING OFF AFTER THIS MEETING 

238
00:12:32,400 --> 00:12:34,600
AFTER GRACIOUSLY AGREEING TO 

239
00:12:34,600 --> 00:12:35,880
SERVE AFTER LAST YEAR A 

240
00:12:35,880 --> 00:12:37,120
SIX-MONTH EXTENSION.

241
00:12:37,120 --> 00:12:39,160
I'D LIKE TO THANK THEM FOR THEIR

242
00:12:39,160 --> 00:12:40,520
SERVICE AND MANY CONTRIBUTIONS 

243
00:12:40,520 --> 00:12:43,320
OVER THE YEARS.

244
00:12:43,320 --> 00:12:48,680
FIRST IS DAVID GLASSER 

245
00:12:48,680 --> 00:12:51,120
ENGINEERING DIRECTOR AND TARA AT

246
00:12:51,120 --> 00:12:52,000
LIFE SCIENCES.

247
00:12:52,000 --> 00:12:56,120
DAVID CO-CHAIRED THE ACD WORKING

248
00:12:56,120 --> 00:12:58,480
GROUP ON CHANGING THE CULTURE ON

249
00:12:58,480 --> 00:13:01,360
SEXUAL HARASSMENT AND A MEMBER 

250
00:13:01,360 --> 00:13:03,040
OF THE WORKING GROUP ON ETHICAL 

251
00:13:03,040 --> 00:13:04,600
CONSIDERATIONS FOR INDUSTRY 

252
00:13:04,600 --> 00:13:06,720
PARTNERSHIP ON RESEARCH TO HELP 

253
00:13:06,720 --> 00:13:11,520
END THE OPIOID CRISIS.

254
00:13:11,520 --> 00:13:14,040
AND HE CO-CHAIRS THE ACD WORKING

255
00:13:14,040 --> 00:13:17,040
GROUP ON ARTIFICIAL INTELLIGENCE

256
00:13:17,040 --> 00:13:20,160
AND TRIED VAINLY TO TRY TO TEACH

257
00:13:20,160 --> 00:13:22,280
ME SOMETHING ABOUT ARTIFICIAL 

258
00:13:22,280 --> 00:13:22,640
INTELLIGENCE.

259
00:13:22,640 --> 00:13:26,080
NOT SURE YOU SUCKCEEDED BUT IT 

260
00:13:26,080 --> 00:13:28,000
WAS THE PUPIL NOT THE TEACHER.

261
00:13:28,000 --> 00:13:31,240
AND THEN THE OFFICER OF THE 

262
00:13:31,240 --> 00:13:34,640
MEDICAL SCHOOL ALONG WITH HIS 

263
00:13:34,640 --> 00:13:38,200
SERVICE ON THE ACD, JAMES SPART 

264
00:13:38,200 --> 00:13:39,760
OF THE FDA'S VACCINE AND 

265
00:13:39,760 --> 00:13:41,160
BIOLOGICAL PRODUCTS ADVISORY 

266
00:13:41,160 --> 00:13:46,840
COMMITTEE AND PRESIDENT BIDEN'S 

267
00:13:46,840 --> 00:13:51,080
COVID-19 EQUITY TASK FORCE.

268
00:13:51,080 --> 00:13:53,560
THOUGH WE ARE LOSING JAMES, NO 

269
00:13:53,560 --> 00:13:54,960
DOUBT WE'LL CONTINUE TO WORK 

270
00:13:54,960 --> 00:13:56,640
CLOSELY WITH HIM IN THE LATTER 

271
00:13:56,640 --> 00:14:02,920
TWO ROLES.

272
00:14:02,920 --> 00:14:05,240
I DON'T KNOW IF EITHER OF YOU 

273
00:14:05,240 --> 00:14:07,760
WANT TO SAY SOMETHING BRIEFLY.

274
00:14:07,760 --> 00:14:08,920
>> THANK YOU FOR THE
OPPORTUNITY

275
00:14:08,920 --> 00:14:13,400
I HAVE LEARNED A LOT AND 

276
00:14:13,400 --> 00:14:15,800
PRIVILEGED TO BE PART OF THIS.

277
00:14:15,800 --> 00:14:17,360
I FEEL I UNDERSTAND MUCH MORE 

278
00:14:17,360 --> 00:14:22,000
THAN I USED ABOUT THE PEOPLE AND

279
00:14:22,000 --> 00:14:24,480
PROCESSES OF ADVANCING HEALTH.

280
00:14:24,480 --> 00:14:26,160
>> THANK YOU.

281
00:14:26,160 --> 00:14:26,360
JAMES.

282
00:14:26,360 --> 00:14:32,120
>> LARRY, I WOULD ECHO
THAT AND 

283
00:14:32,120 --> 00:14:34,480
LEARNED A GREAT DEAL AND HAPPY 

284
00:14:34,480 --> 00:14:35,880
TO BE PART OF THIS IMPORTANT 

285
00:14:35,880 --> 00:14:37,360
GROUP AND THE CONVERSATIONS 

286
00:14:37,360 --> 00:14:39,440
WE'VE HAD AND WISH YOU SUCCESS 

287
00:14:39,440 --> 00:14:40,640
IN THE TRANSITION HAPPENING 

288
00:14:40,640 --> 00:14:40,840
HERE.

289
00:14:40,840 --> 00:14:45,000
THANK YOU, I APPRECIATE IT.

290
00:14:45,000 --> 00:14:46,160
>> SO EVERYBODY IS CLEAR,
WE 

291
00:14:46,160 --> 00:14:48,360
LEARNED A LOT MORE FROM THESE 

292
00:14:48,360 --> 00:14:50,440
TWO GENTLEMEN THAN THEY LEARNED 

293
00:14:50,440 --> 00:14:54,240
FROM US.

294
00:14:54,240 --> 00:15:03,280
WE'RE VERY APPRECIATIVE.

295
00:15:03,280 --> 00:15:06,400
IF WE CAN VIRTUALLY THANK THEM, 

296
00:15:06,400 --> 00:15:07,520
THAT'D BE GREAT.

297
00:15:07,520 --> 00:15:09,800
NEXT, WE HAVE SEVERAL NEW 

298
00:15:09,800 --> 00:15:11,360
MEMBERS OFFICIALLY JOINING THE 

299
00:15:11,360 --> 00:15:14,160
ACD AT THIS MEETING AND PLEASED,

300
00:15:14,160 --> 00:15:16,080
IF I MISPRONOUNCE YOUR NAME, 

301
00:15:16,080 --> 00:15:25,000
DESPITE PRACTICING, CORRECT ME 

302
00:15:25,000 --> 00:15:25,320
IMMEDIATELY.

303
00:15:25,320 --> 00:15:25,920
DON'T WAIT.

304
00:15:25,920 --> 00:15:34,400
THE FIRST NEW MEMBER IS IS THE 

305
00:15:34,400 --> 00:15:37,160
MARK ZUCKERBERG DISTINGUISHED 

306
00:15:37,160 --> 00:15:39,720
PROFESSOR OF PEDIATRICS, 

307
00:15:39,720 --> 00:15:41,680
BIOENGINEERING AND SCIENCES AND 

308
00:15:41,680 --> 00:15:45,040
BIOSTATISTICS AT UCSF AND THE 

309
00:15:45,040 --> 00:15:47,080
CHIEF DATA SCIENTIST FOR THE 

310
00:15:47,080 --> 00:15:47,720
UNIVERSITY OF CALIFORNIA HEALTH 

311
00:15:47,720 --> 00:15:53,640
SYSTEM.

312
00:15:53,640 --> 00:15:56,480
WELCOME ATUL.

313
00:15:56,480 --> 00:16:02,160
HOWARD CHANG THE PROFESSOR OF 

314
00:16:02,160 --> 00:16:06,720
CANCER RESEARCH AT STANFORD 

315
00:16:06,720 --> 00:16:08,120
UNIVERSITY.

316
00:16:08,120 --> 00:16:12,320
THE DIRECTOR AND FOUNDER OF ICAP

317
00:16:12,320 --> 00:16:13,640
FORMALLY THE INTERNATIONAL 

318
00:16:13,640 --> 00:16:14,520
CENTER FOR AIDS CARE AND 

319
00:16:14,520 --> 00:16:18,080
TREATMENT PROGRAMS.

320
00:16:18,080 --> 00:16:24,720
THE DIRECTOR OF COLUMBIA WORLD 

321
00:16:24,720 --> 00:16:28,320
PROJECTS AND CHAIR OF GLOBAL 

322
00:16:28,320 --> 00:16:32,680
HEALTH AND SCHOOL OF PUBLIC 

323
00:16:32,680 --> 00:16:34,840
HEALTH AT COLUMBIA UNIVERSITY.

324
00:16:34,840 --> 00:16:45,360
THE NEXT NEW MEMBER, THE ENDOWED

325
00:16:47,400 --> 00:16:48,160
ASSOCIATE PROFESSOR, DEPARTMENT 

326
00:16:48,160 --> 00:16:51,400
OF PSYCHIATRY AND BEHAVIORAL 

327
00:16:51,400 --> 00:16:55,560
SCIENCES AT DUKE UNIVERSITY 

328
00:16:55,560 --> 00:16:58,600
MEDICAL CENTER THEY SERVED ON 

329
00:16:58,600 --> 00:17:01,080
THE ACD BRAIN INITIATIVE WORKING

330
00:17:01,080 --> 00:17:10,360
GROUP AS AN AD HOC MEMBER.

331
00:17:10,360 --> 00:17:13,240
THEN GARTH GRAM AT YOUTUBE AND 

332
00:17:13,240 --> 00:17:14,760
GOOGLE HEALTH.

333
00:17:14,760 --> 00:17:17,960
MANY OF US KNOW GARTH DURING HIS

334
00:17:17,960 --> 00:17:22,720
PREVIOUS SERVICE AS U.S. DEPUTY 

335
00:17:22,720 --> 00:17:25,040
ASSISTANT SECRETARY FOR HEALTH.

336
00:17:25,040 --> 00:17:28,640
GARTH HAS JUMPED IN AND 

337
00:17:28,640 --> 00:17:31,160
GRACIOUSLY AGREED TO BE THE NEW 

338
00:17:31,160 --> 00:17:34,000
CO-CHAIR TO THE GENOME DATA 

339
00:17:34,000 --> 00:17:35,120
ACCESS GROUP.

340
00:17:35,120 --> 00:17:38,040
WE DON'T HAVE REQUESTS FOR THE 

341
00:17:38,040 --> 00:17:40,200
HELO GENOME WORKING GROUP FOR 

342
00:17:40,200 --> 00:17:41,960
THIS ACD MEETING BUT I WANTED TO

343
00:17:41,960 --> 00:17:52,120
 RTANT THIS AGREEMENT IS IS 

344
00:17:52,120 --> 00:17:56,480
WITH THE LACK FAMILY AND WE 

345
00:17:56,480 --> 00:17:57,800
THANK YOU FOR THEIR CONTINUOUS 

346
00:17:57,800 --> 00:17:59,680
SUPPORT OF RESEARCH AND 

347
00:17:59,680 --> 00:18:00,840
WILLINGNESS TO COLLABORATE ON 

348
00:18:00,840 --> 00:18:03,600
THIS IMPORTANT ISSUE.

349
00:18:03,600 --> 00:18:04,880
YOU MAY RECALL NIH LACKS 

350
00:18:04,880 --> 00:18:08,120
AGREEMENT WAS CREATED IN 2013 TO

351
00:18:08,120 --> 00:18:10,080
ESTABLISH A MUTUALLY 

352
00:18:10,080 --> 00:18:11,720
COLLABORATIVE EFFORT REFLECTING 

353
00:18:11,720 --> 00:18:15,360
THE WISHES OF THE LACKS FAMILY 

354
00:18:15,360 --> 00:18:19,680
REGARDING RESEARCH USING HELA 

355
00:18:19,680 --> 00:18:22,280
CELLS WHILE RESPECTING THE 

356
00:18:22,280 --> 00:18:22,520
FAMILY.

357
00:18:22,520 --> 00:18:24,080
IT PUTS ACCOUNTABILITY AND 

358
00:18:24,080 --> 00:18:25,840
REVIEW OF INVESTIGATOR REQUESTS 

359
00:18:25,840 --> 00:18:30,320
FOR ACCESS TO THE HELA CELL 

360
00:18:30,320 --> 00:18:31,360
GENOME SEQUENCE DATA THROUGH THE

361
00:18:31,360 --> 00:18:31,560
ACD.

362
00:18:31,560 --> 00:18:37,120
WE WANT TO THANK THE FAMILY AND 

363
00:18:37,120 --> 00:18:40,240
THE SCIENTIFIC COMMUNITY FOR 

364
00:18:40,240 --> 00:18:45,000
THEIR CONTINUED COMMITMENT TO 

365
00:18:45,000 --> 00:18:46,040
UPHOLDING THIS AGREEMENT.

366
00:18:46,040 --> 00:18:47,440
I'D LIKE TO THANK THE CO-CHAIR 

367
00:18:47,440 --> 00:18:52,640
FOR HIS LEADERSHIP ON IS THIS 

368
00:18:52,640 --> 00:18:53,360
IMPORTANT GROUP.

369
00:18:53,360 --> 00:18:55,920
AND VITAL TO THE ONGOING 

370
00:18:55,920 --> 00:18:59,520
SUCCESSION IN ENJOYING THE 

371
00:18:59,520 --> 00:19:01,520
LACKS' FAMILY PRIVACY AND WE 

372
00:19:01,520 --> 00:19:03,240
LOOK FORWARD TO WORKING WITH 

373
00:19:03,240 --> 00:19:05,080
GARTH IN HIS NEW ROLE.

374
00:19:05,080 --> 00:19:07,560
IF YOU'D ALL JOIN ME IN 

375
00:19:07,560 --> 00:19:08,720
WELCOMING ALL THE NEWEST MEMBERS

376
00:19:08,720 --> 00:19:18,920
OF THE ACD.

377
00:19:23,920 --> 00:19:24,520
OKAY.

378
00:19:24,520 --> 00:19:30,520
SO WE HAVE A SERIES OF NEW 

379
00:19:30,520 --> 00:19:34,560
APPOINTMENTS, DEPARTURES AND 

380
00:19:34,560 --> 00:19:34,800
SEARCHS.

381
00:19:34,800 --> 00:19:36,760
FOLLOWING FRANCIS' RETIREMENT AS

382
00:19:36,760 --> 00:19:38,560
NIH DIRECTOR AND MY SHIFT TO THE

383
00:19:38,560 --> 00:19:40,520
ACTING DIRECTOR ROLE, DR. TARA 

384
00:19:40,520 --> 00:19:44,400
SCHWETZ IS NOW SERVING AS THE 

385
00:19:44,400 --> 00:19:46,920
ACTING NIH PRINCIPAL DIRECTOR 

386
00:19:46,920 --> 00:19:48,320
AND YOU'LL BE SEEING AND HEARING

387
00:19:48,320 --> 00:19:52,480
A LOT FROM TARA DURING THIS ACD 

388
00:19:52,480 --> 00:19:55,880
MEETING AND BEYOND.

389
00:19:55,880 --> 00:20:02,080
IF I MAY HAVE THE NEXT SLIDE, 

390
00:20:02,080 --> 00:20:02,800
PLEASE.

391
00:20:02,800 --> 00:20:07,120
SLOT BEING INTO TARA'S ROLE AS 

392
00:20:07,120 --> 00:20:12,040
DIRECTOR, DR. ACLUND THE ACT 

393
00:20:12,040 --> 00:20:17,920
SOCIETY DEPUTY DIRECTOR AND 

394
00:20:17,920 --> 00:20:23,320
PREVIOUSLY REPORTED, WITH CARRIE

395
00:20:23,320 --> 00:20:27,760
MO

396
00:20:27,760 --> 00:20:30,120
MOLENETS ON DETAIL AT THE WHITE 

397
00:20:30,120 --> 00:20:30,880
HOUSE AND IF I CAN HAVE THE NEXT

398
00:20:30,880 --> 00:20:36,960
SLIDE.

399
00:20:36,960 --> 00:20:39,320
YOU KNOW DR. NED SHARPLESS 

400
00:20:39,320 --> 00:20:42,200
STEPPED DOWN FROM HIS ROLE AS 

401
00:20:42,200 --> 00:20:43,920
DIRECTOR AND WE ALL OWE A GREAT 

402
00:20:43,920 --> 00:20:44,960
DEAL OF GRATITUDE FOR HIS 

403
00:20:44,960 --> 00:20:48,560
SERVICE.

404
00:20:48,560 --> 00:20:51,960
WITH THE DEPARTURE OF NED, 

405
00:20:51,960 --> 00:21:01,040
DR. LOWE IS REPRIDESING  -- 

406
00:21:01,040 --> 00:21:02,720
REPRISING HIS ROLE AS THE 

407
00:21:02,720 --> 00:21:04,040
DIRECTOR AND IT'S A THE SECOND 

408
00:21:04,040 --> 00:21:05,080
TIME HE'S SERVED IN THAT 

409
00:21:05,080 --> 00:21:06,720
IMPORTANT CAPACITY.

410
00:21:06,720 --> 00:21:12,080
SIMILARLY, IF I CAN HAVE THE 

411
00:21:12,080 --> 00:21:16,320
NEXT SLIDE, WE HAVE AN ACTING 

412
00:21:16,320 --> 00:21:18,240
DIRECTOR OF THE NATIONAL CENTER 

413
00:21:18,240 --> 00:21:20,000
FOR TRANSLATION SCIENCES 

414
00:21:20,000 --> 00:21:23,120
FOLLOWING THE DEPARTURE OF CHRIS

415
00:21:23,120 --> 00:21:27,840
AUSTIN.

416
00:21:27,840 --> 00:21:30,680
AND DR. CHRISTINE HUNTER IS 

417
00:21:30,680 --> 00:21:34,600
FILLING IN DUAL ROLES AS 

418
00:21:34,600 --> 00:21:36,440
DIRECTOR TO BEHAVIORAL AND 

419
00:21:36,440 --> 00:21:37,920
SCIENCES RESEARCH AND THE OFFICE

420
00:21:37,920 --> 00:21:40,480
OF BEHAVIORAL AND SOCIAL 

421
00:21:40,480 --> 00:21:49,680
SCIENCES RESEARCH.

422
00:21:49,680 --> 00:21:51,160
DR. BERKOW CONTINUES TO ROLE AS 

423
00:21:51,160 --> 00:21:52,600
ACTING CHIEF OF STAFF.

424
00:21:52,600 --> 00:21:59,920
A ROLE HE BEGAN WHILE FRANCIS 

425
00:21:59,920 --> 00:22:02,120
WAS STILL DIRECTOR AND FOR 

426
00:22:02,120 --> 00:22:06,400
CONTINUING TO SERVE AS THE 

427
00:22:06,400 --> 00:22:08,040
ACT

428
00:22:08,040 --> 00:22:12,120
ACTING ASSOCIATE DIRECTOR AND 

429
00:22:12,120 --> 00:22:12,560
PUBLIC LIAISON.

430
00:22:12,560 --> 00:22:14,920
WHEN PEOPLE ARE ASKING ME HOW I 

431
00:22:14,920 --> 00:22:17,200
AM, MAYBE I DON'T LOOK WELL, 

432
00:22:17,200 --> 00:22:18,960
THEY'RE ALWAYS ASKING HOW I'M 

433
00:22:18,960 --> 00:22:22,400
DOING AND I ASSURE I'M DOING 

434
00:22:22,400 --> 00:22:24,480
REALLY WELL BECAUSE OF THESE 

435
00:22:24,480 --> 00:22:26,400
FOLKS AND THE OTHER LEADERSHIP 

436
00:22:26,400 --> 00:22:27,560
TEAM ACROSS NIH.

437
00:22:27,560 --> 00:22:28,560
I'M ABLE TO COUNT ON THEM EACH 

438
00:22:28,560 --> 00:22:30,360
AND EVERY DAY.

439
00:22:30,360 --> 00:22:32,880
THOSE WHO REMAIN IN THEIR ROLES 

440
00:22:32,880 --> 00:22:37,160
AND THOSE WHO HAVE TAKEN ON THE 

441
00:22:37,160 --> 00:22:38,840
ACTING ROLES WE'RE VERY 

442
00:22:38,840 --> 00:22:40,920
FORTUNATE TO HAVE SUCH A DEEP 

443
00:22:40,920 --> 00:22:44,400
BENCH WE CAN RAPIDLY FILL SO 

444
00:22:44,400 --> 00:22:45,920
MANY KEY ROLES AT THE AGENCY 

445
00:22:45,920 --> 00:22:51,160
WITH PEOPLE WHO ARE READY TO 

446
00:22:51,160 --> 00:22:53,840
STEP IN.

447
00:22:53,840 --> 00:22:56,600
THAT'S MORE OF WHAT WE MEAN WHEN

448
00:22:56,600 --> 00:22:58,360
WE SAY SUCCESSION PLANNING IN A 

449
00:22:58,360 --> 00:22:59,480
GOVERNMENT ENTITY.

450
00:22:59,480 --> 00:23:02,440
THE INDIVIDUALS WHO STEP IN 

451
00:23:02,440 --> 00:23:04,440
AREN'T NECESSARY GOING TO BECOME

452
00:23:04,440 --> 00:23:06,400
THE PERMANENT HOLDERS OF THE 

453
00:23:06,400 --> 00:23:07,800
POSITION BUT THEY'RE WILLING TO 

454
00:23:07,800 --> 00:23:12,400
STEP IN FOR SOME PERIOD OF TIME 

455
00:23:12,400 --> 00:23:14,360
AND DO SUPERB JOBS.

456
00:23:14,360 --> 00:23:16,560
I'M TREMENDOUSLY GRATEFUL TO ALL

457
00:23:16,560 --> 00:23:24,880
OF THOSE FOLKS.

458
00:23:24,880 --> 00:23:27,520
SO YOU'LL HERE A GREAT DEAL MORE

459
00:23:27,520 --> 00:23:28,520
ABOUT THIS LATER FROM 

460
00:23:28,520 --> 00:23:33,720
DR. SCHWETZ BUT THE CREATION OF 

461
00:23:33,720 --> 00:23:37,560
THE NEW ADVANCE ARPA-H SECRETARY

462
00:23:37,560 --> 00:23:40,480
BECERRA APPOINTED DR. RUSSELL AS

463
00:23:40,480 --> 00:23:42,200
ACTING DEPUTY DIRECTOR OF 

464
00:23:42,200 --> 00:23:43,000
ARPA-H.

465
00:23:43,000 --> 00:23:47,240
IN THIS ROLE, ADAM WILL LEAD THE

466
00:23:47,240 --> 00:23:49,600
PROCESS BY BUILDING OUT THE 

467
00:23:49,600 --> 00:23:50,280
INFRASTRUCTURE, BUSINESS 

468
00:23:50,280 --> 00:23:53,600
PROCESSES AND POLICIES.

469
00:23:53,600 --> 00:23:56,600
ADDITIONAL STAFF WILL BE BROUGHT

470
00:23:56,600 --> 00:23:57,920
ONBOARD TO HELP BUILD THE 

471
00:23:57,920 --> 00:24:01,320
OPERATIONAL ELEMENTS YOU NEED IN

472
00:24:01,320 --> 00:24:03,080
STANDING UP A NEW ORGANIZATION 

473
00:24:03,080 --> 00:24:05,280
WHILE PRESIDENT BIDEN SEARCHS 

474
00:24:05,280 --> 00:24:10,480
FOR THE PRESIDENTIALLY APPOINTED

475
00:24:10,480 --> 00:24:12,000
INAUGURAL DIRECTOR.

476
00:24:12,000 --> 00:24:14,120
I SHOULD HAVE ADDED THE 

477
00:24:14,120 --> 00:24:17,200
PRESIDENT CONDUCTING A SEARCH 

478
00:24:17,200 --> 00:24:19,240
FOR THE APPOINTED NCI DIRECTOR 

479
00:24:19,240 --> 00:24:29,400
AS WELL.

480
00:24:32,480 --> 00:24:36,000
AND I'D LIKE TO WELCOME THE 

481
00:24:36,000 --> 00:24:37,680
FORMER CDC DIRECTOR DURING THE 

482
00:24:37,680 --> 00:24:39,800
BUSH ADMINISTRATION AND IS 

483
00:24:39,800 --> 00:24:43,520
APPOINTED THE NEW CEO FOR THE 

484
00:24:43,520 --> 00:24:48,640
FOUNDATION OF NIH.

485
00:24:48,640 --> 00:24:51,240
PRIOR, DR. GERBERDING WAS IN 

486
00:24:51,240 --> 00:24:53,840
POPULATION HEALTH AND 

487
00:24:53,840 --> 00:24:55,600
SUSTAINABILITY AT MERCK.

488
00:24:55,600 --> 00:24:59,000
WE'RE DELIGHTED TO HAVE JULIE 

489
00:24:59,000 --> 00:25:04,440
JOIN IN THIS VERY IMPORTANT ROLE

490
00:25:04,440 --> 00:25:09,320
GIVEN THE INCREASING 

491
00:25:09,320 --> 00:25:10,320
COLLABORATION HAS PLAYED IN A 

492
00:25:10,320 --> 00:25:11,000
NUMBER OF THINGS WE'RE ENGAGED 

493
00:25:11,000 --> 00:25:17,960
IN.

494
00:25:17,960 --> 00:25:19,840
NOW WE'LL DO AWARDS AND 

495
00:25:19,840 --> 00:25:25,400
HONOREES.

496
00:25:25,400 --> 00:25:27,240
I'M DELIGHTED TO SHARE THE NEWS.

497
00:25:27,240 --> 00:25:31,600
FIRST TWO FINAL EFFISTS TO THE 

498
00:25:31,600 --> 00:25:34,680
SERVICE TO AMERICA KNOWN AS THE 

499
00:25:34,680 --> 00:25:34,920
SAMIS.

500
00:25:34,920 --> 00:25:38,920
DR. BIANCHI WAS A FINALIST FOR 

501
00:25:38,920 --> 00:25:42,920
THE COVID-19 RESPONSE CATEGORY 

502
00:25:42,920 --> 00:25:44,880
AND DR. CLIFF LANE WHO HAS 

503
00:25:44,880 --> 00:25:45,440
ADVANCED IN THE CAREER 

504
00:25:45,440 --> 00:25:55,800
ACHIEVEMENT CATEGORY.

505
00:25:57,600 --> 00:26:00,720
AND THE ADVOCACY AWARD TWO 

506
00:26:00,720 --> 00:26:04,560
PEOPLE WELL KNOWN TO US FRANCIS 

507
00:26:04,560 --> 00:26:08,480
COLLINS WHO AS YOU KNOW IS NOW 

508
00:26:08,480 --> 00:26:14,480
SERVING AS THE ACTING SCIENCE 

509
00:26:14,480 --> 00:26:15,680
ADVISER TO THE PRESIDENT IN 

510
00:26:15,680 --> 00:26:20,160
ADDITION TO RUNNING HIS GENOMICS

511
00:26:20,160 --> 00:26:26,400
PROGRAM AND DR. VIVIAN PINN 

512
00:26:26,400 --> 00:26:32,080
AWARDED FOR HER ACHIEVEMENTS IN 

513
00:26:32,080 --> 00:26:34,840
PUBLIC HEALTH AND EVERYONE FOR 

514
00:26:34,840 --> 00:26:40,480
THEIR WORK IN RAPID IN THE RAPID

515
00:26:40,480 --> 00:26:42,520
TRANSLATIONAL ROLE.

516
00:26:42,520 --> 00:26:43,680
AGAIN VERY FAMILIAR FACES ADDING

517
00:26:43,680 --> 00:26:47,200
TO THE MANY ACCOLADES.

518
00:26:47,200 --> 00:26:51,280
DR. TONY FAUCI HAD BEEN AWARDED 

519
00:26:51,280 --> 00:26:56,320
THE EXCELLENCE IN PUBLIC SERVICE

520
00:26:56,320 --> 00:26:56,680
AWARD.

521
00:26:56,680 --> 00:26:59,760
THESE ARE JUST A SAMPLING OF THE

522
00:26:59,760 --> 00:27:01,360
MANY AWARDS THAT OUR STAFF HAVE 

523
00:27:01,360 --> 00:27:11,520
RECEIVED.

524
00:27:22,080 --> 00:27:25,640
AND BUDGET AND LEGISLATIVE 

525
00:27:25,640 --> 00:27:26,280
UPDATES.

526
00:27:26,280 --> 00:27:28,160
THIS IS A SHOT OF MY COLLEAGUES 

527
00:27:28,160 --> 00:27:32,280
AND I PARTICIPATING IN THE HOUSE

528
00:27:32,280 --> 00:27:32,800
APPROPRIATIONS COMMITTEE 

529
00:27:32,800 --> 00:27:41,160
HEARING.

530
00:27:41,160 --> 00:27:45,840
AND THIS IS THE SENATE 

531
00:27:45,840 --> 00:27:46,280
APPROPRIATIONS.

532
00:27:46,280 --> 00:27:52,480
I'LL HIGH  -- SAY AT A HIGH 

533
00:27:52,480 --> 00:27:55,320
LEVEL THE TEAM WAS VERY TO 

534
00:27:55,320 --> 00:27:56,400
PROVIDE CLEAR AND THOROUGH 

535
00:27:56,400 --> 00:27:59,160
ANSWERS TO ALL THE MEMBERS A 

536
00:27:59,160 --> 00:28:02,120
QUESTIONS AND WE WERE PLEASED 

537
00:28:02,120 --> 00:28:03,680
THAT THE HEARING WAS 

538
00:28:03,680 --> 00:28:10,920
PROFESSIONAL IN BOTH INSTANCES 

539
00:28:10,920 --> 00:28:21,400
AND I'LL PASS IT ON TO NEIL 

540
00:28:22,960 --> 00:28:25,400
SHAPIRO AND ADRIENNE HALLET FOR 

541
00:28:25,400 --> 00:28:27,640
THE BUDGETS AND LEGISLATIVE 

542
00:28:27,640 --> 00:28:28,280
ACTIVITY.

543
00:28:28,280 --> 00:28:29,920
NEIL, PLEASE TAKE IT AWAY.

544
00:28:29,920 --> 00:28:32,520
>> GOOD MORNING, EVERYONE.

545
00:28:32,520 --> 00:28:41,400
CAN YOU HEAR ME?

546
00:28:41,400 --> 00:28:43,000
STARTING WITH THE CURRENT FISCAL

547
00:28:43,000 --> 00:28:46,160
YEAR, 2022, WE RECEIVED THE 

548
00:28:46,160 --> 00:28:48,320
CONSOLIDATED APPROPRIATIONS BILL

549
00:28:48,320 --> 00:28:49,480
ON MARCH 15 AFTER FOUR 

550
00:28:49,480 --> 00:28:52,360
CONTINUING RESOLUTIONS OR C.R.s.

551
00:28:52,360 --> 00:28:54,120
JUST TO RECAP OF WHAT IS 

552
00:28:54,120 --> 00:28:55,440
SUPPOSED TO HAPPEN, 

553
00:28:55,440 --> 00:28:56,880
APPROPRIATIONS ARE SUPPOSED TO 

554
00:28:56,880 --> 00:28:59,320
BE PASSED BY THE END OF 

555
00:28:59,320 --> 00:29:00,720
SEPTEMBER SO WE HAVE THEM 

556
00:29:00,720 --> 00:29:04,480
AVAILABLE FOR THE FISCAL YEAR 

557
00:29:04,480 --> 00:29:07,480
STARTING OCTOBER 1.

558
00:29:07,480 --> 00:29:09,920
THAT HAS ONLY HAPPENED ONCE AND 

559
00:29:09,920 --> 00:29:11,920
WE START THE YEAR WITH 

560
00:29:11,920 --> 00:29:12,800
CONTINUING RESOLUTION WHERE 

561
00:29:12,800 --> 00:29:13,720
ESSENTIALLY WE OPERATE UNDER THE

562
00:29:13,720 --> 00:29:16,480
SAME FUNDING LEVEL AS THE PRIOR 

563
00:29:16,480 --> 00:29:19,440
YEARS' ENACTED APPROPRIATION SO 

564
00:29:19,440 --> 00:29:23,000
WE WERE UNDER THE 21 LEVEL UNTIL

565
00:29:23,000 --> 00:29:25,280
CONGRESS PASSED THIS OMNIBUS ON 

566
00:29:25,280 --> 00:29:28,000
MARCH 15 AND AS I SAID, THAT'S 

567
00:29:28,000 --> 00:29:30,640
NEARLY HALF THE FISCAL YEAR FROM

568
00:29:30,640 --> 00:29:32,520
OCTOBER THROUGH MID MARCH SO 

569
00:29:32,520 --> 00:29:34,040
THAT POSES CHALLENGES IN TERMS 

570
00:29:34,040 --> 00:29:38,760
OF SPENDING A HIGHER LEVEL IN 

571
00:29:38,760 --> 00:29:41,000
THE SECOND HALF OF YEAR.

572
00:29:41,000 --> 00:29:43,560
WE'RE SOMEWHAT ACCUSTOMED TO 

573
00:29:43,560 --> 00:29:44,160
DEALING WITH THAT PARTICULAR 

574
00:29:44,160 --> 00:29:46,120
CHALLENGE.

575
00:29:46,120 --> 00:29:49,520
ANOTHER THING WE'LL TALK ABOUT 

576
00:29:49,520 --> 00:29:51,640
MORE LATER IS THE CREATE OF 

577
00:29:51,640 --> 00:29:53,840
ARPA-H ALSO IN THE OMNIBUS BILL.

578
00:29:53,840 --> 00:29:57,000
CONGRESS PUT IN A PROVISION AND 

579
00:29:57,000 --> 00:30:01,960
CREATED ARPA-H WITHIN THE 

580
00:30:01,960 --> 00:30:04,480
DEPARTMENT OF HHS WITH THE 

581
00:30:04,480 --> 00:30:05,480
AUTHORITY TO CONTROVERSY IT 

582
00:30:05,480 --> 00:30:08,200
WHICH ACTUALLY HAPPENED AND THE 

583
00:30:08,200 --> 00:30:10,920
TYPE 1 DIABETES FUND IS PART OF 

584
00:30:10,920 --> 00:30:13,520
THE ANNUAL FUNDING PROFILE THAT 

585
00:30:13,520 --> 00:30:15,200
IS NOT IN THE REGULAR 

586
00:30:15,200 --> 00:30:16,360
APPROPRIATIONS BILL.

587
00:30:16,360 --> 00:30:18,640
IT'S CALLED MANDATORY FUNDING 

588
00:30:18,640 --> 00:30:22,720
AND COMES IN AN AUTHORIZING BILL

589
00:30:22,720 --> 00:30:26,240
INSTEAD OF ANS BILL.

590
00:30:26,240 --> 00:30:28,440
-- AN APPROPRIATIONS BILL AND 

591
00:30:28,440 --> 00:30:30,080
MAY BE RE-AUTHORIZED FOR YEARS 

592
00:30:30,080 --> 00:30:32,000
AND GOOD TO KNOW WE WILL HAVE 

593
00:30:32,000 --> 00:30:34,360
THE MONEY IN FOLLOWING YEARS 

594
00:30:34,360 --> 00:30:36,240
SINCE IT DOESN'T NECESSARILY GET

595
00:30:36,240 --> 00:30:37,280
INCLUDED IN THE ANNUAL 

596
00:30:37,280 --> 00:30:38,280
APPROPRIATION.

597
00:30:38,280 --> 00:30:40,120
THE FLIP SIDE IS UNDER CURRENT 

598
00:30:40,120 --> 00:30:42,240
LAW WHEN IT HAPPENS FAR ENOUGH 

599
00:30:42,240 --> 00:30:45,400
IN ADVANCE, WE LOSE A BIT OF THE

600
00:30:45,400 --> 00:30:46,680
MONEY THROUGH SEQUESTRATION.

601
00:30:46,680 --> 00:30:52,480
THIS YEAR WE DID TAKE AN $8.5 

602
00:30:52,480 --> 00:30:57,360
MILLION HIT.

603
00:30:57,360 --> 00:31:01,600
THIS IS A SUMMARY OF OUR FY22 

604
00:31:01,600 --> 00:31:02,240
APPROPRIATION.

605
00:31:02,240 --> 00:31:05,880
ARPA-H WAS FUNDED AT $1 BILLION 

606
00:31:05,880 --> 00:31:08,480
OVER A THREE-YEAR PERIOD WITH A 

607
00:31:08,480 --> 00:31:09,600
NEW AGENCY.

608
00:31:09,600 --> 00:31:10,560
WE'LL NEED ADDITIONAL YEARS IN 

609
00:31:10,560 --> 00:31:13,240
ORDER TO GET THAT GOING AND BE 

610
00:31:13,240 --> 00:31:16,640
ABLE TO SPEND THE MONEY WHICH IS

611
00:31:16,640 --> 00:31:17,000
AVAILABLE.

612
00:31:17,000 --> 00:31:19,400
NORMALLY NIH FUNDS ARE ONE-YEAR 

613
00:31:19,400 --> 00:31:20,480
APPROPRIATIONS WHICH MEANS WE 

614
00:31:20,480 --> 00:31:24,000
HAVE TO OBLIGATE THEM AND GET 

615
00:31:24,000 --> 00:31:25,400
THEM OUT THE DOOR.

616
00:31:25,400 --> 00:31:29,280
WITH ARPA-H THERE'LL BE TWO 

617
00:31:29,280 --> 00:31:31,240
ADDITIONAL YEARS.

618
00:31:31,240 --> 00:31:33,160
THE INCREASE WAS A HEALTHY ONE.

619
00:31:33,160 --> 00:31:36,120
IT FOLLOWS ON SEVERAL YEARS OF 

620
00:31:36,120 --> 00:31:38,600
HEALTHY INCREASES.

621
00:31:38,600 --> 00:31:43,680
SINCE FISCAL 2016 AFTER SEVERAL 

622
00:31:43,680 --> 00:31:48,480
YEARS WE ESSENTIALLY HAD A FLAT 

623
00:31:48,480 --> 00:31:51,400
BUDGET AND RECEIVED INCREASES 

624
00:31:51,400 --> 00:31:53,800
TAKING OUR FUNDING UP ROUGHLY 

625
00:31:53,800 --> 00:31:55,160
50% OVER SEVEN YEARS.

626
00:31:55,160 --> 00:31:57,480
THAT'S BEEN VERY WELCOME AND 

627
00:31:57,480 --> 00:31:58,920
APPRECIATIVE CONGRESS HAS BEEN 

628
00:31:58,920 --> 00:32:00,480
ABLE TO SUPPORT US THAT WAY IN 

629
00:32:00,480 --> 00:32:04,560
RECENT YEARS.

630
00:32:04,560 --> 00:32:06,600
INCLUDED IN THAT WAS THE GENERAL

631
00:32:06,600 --> 00:32:11,240
INCREASE OF 3.4%.

632
00:32:11,240 --> 00:32:13,880
THIS IS ALWAYS A CONCERN HOW 

633
00:32:13,880 --> 00:32:15,000
MUCH OF AN ANNUAL APPROPRIATION 

634
00:32:15,000 --> 00:32:16,440
INCREASE IS AVAILABLE TO THE 

635
00:32:16,440 --> 00:32:17,680
INSTITUTES AND CENTERS FOR 

636
00:32:17,680 --> 00:32:20,480
GENERAL PURPOSES AS OPPOSED TO 

637
00:32:20,480 --> 00:32:22,440
BEING TARGETED AT SPECIFIC 

638
00:32:22,440 --> 00:32:25,360
RESEARCH OR OTHER INITIATIVES TO

639
00:32:25,360 --> 00:32:33,200
GIVE YOU A CONTEXT THE 7.9% IF 

640
00:32:33,200 --> 00:32:36,240
YOU TAKE OUT ARPA-H IS ABOUT 60%

641
00:32:36,240 --> 00:32:37,240
GENERAL AND 40% FOR SPECIFIC 

642
00:32:37,240 --> 00:32:45,840
INITIATIVES.

643
00:32:45,840 --> 00:32:48,360
THIS LISTS THE LARGEST OF THE 

644
00:32:48,360 --> 00:32:50,360
TARGETED INCREASES IN THE 

645
00:32:50,360 --> 00:32:50,680
OMNIBUS.

646
00:32:50,680 --> 00:32:51,680
ALZHEIMER'S DISEASE.

647
00:32:51,680 --> 00:32:54,200
THIS HAS TYPICALLY BEEN THE 

648
00:32:54,200 --> 00:32:56,480
BIGGEST PRIORITY FOR CONGRESS 

649
00:32:56,480 --> 00:32:57,840
AMONG THE INITIATIVES.

650
00:32:57,840 --> 00:33:00,160
$289 MILLION THIS YEAR.

651
00:33:00,160 --> 00:33:02,000
IT'S BEEN A LITTLE HIGHER THAN 

652
00:33:02,000 --> 00:33:07,280
THAT IN SOME PREVIOUS YEARS.

653
00:33:07,280 --> 00:33:15,080
THE SECOND THE INITIATIVE MAKES 

654
00:33:15,080 --> 00:33:16,920
IT DIFFICULT TO FUND ALL 

655
00:33:16,920 --> 00:33:18,480
MERITORIOUS APPLICATIONS SO 

656
00:33:18,480 --> 00:33:19,680
CONGRESS TRIED TO SUPPORT THEM 

657
00:33:19,680 --> 00:33:21,520
WIN ADDITIONAL FUNDING TO TRY TO

658
00:33:21,520 --> 00:33:23,240
GET THAT SUCCESS RATE HIGHER.

659
00:33:23,240 --> 00:33:25,280
AND THEN A NUMBER OF 

660
00:33:25,280 --> 00:33:27,160
INITIATIVES, MANY OF WHICH WERE 

661
00:33:27,160 --> 00:33:30,360
REQUESTED IN THE PRESIDENT'S 

662
00:33:30,360 --> 00:33:32,240
BUDGET FOR '22.

663
00:33:32,240 --> 00:33:34,120
THE HEAL INITIATIVE, FOR 

664
00:33:34,120 --> 00:33:35,840
EXAMPLE, BUILDINGS AND 

665
00:33:35,840 --> 00:33:36,960
FACILITIES, CYBER SECURITY, 

666
00:33:36,960 --> 00:33:42,040
THESE ARE ALL PRIORITIES FOR NIH

667
00:33:42,040 --> 00:33:43,600
WE'RE HAPPY CONGRESS WAS ABLE TO

668
00:33:43,600 --> 00:33:43,840
SUPPORT.

669
00:33:43,840 --> 00:33:46,240
THE BRAIN INITIATIVE AND ALL OF 

670
00:33:46,240 --> 00:33:50,040
US RESEARCH PROGRAM THOSE WERE 

671
00:33:50,040 --> 00:33:53,240
PLANNED INCREASES THAT PROVIDED 

672
00:33:53,240 --> 00:33:55,040
A FUNDING PROFILE FOR THOSE 

673
00:33:55,040 --> 00:33:55,280
PROGRAMS.

674
00:33:55,280 --> 00:33:56,840
THAT CONTINUES WITH THE 

675
00:33:56,840 --> 00:34:07,360
STATUTORY LEVEL THERE.

676
00:34:07,360 --> 00:34:10,120
HEALTH DISPARITIES AND THE 

677
00:34:10,120 --> 00:34:12,280
COVID-19 FUNDING FOR TARGETED 

678
00:34:12,280 --> 00:34:13,360
RESEARCH ON AREAS OF COVID-19 

679
00:34:13,360 --> 00:34:15,360
WHERE WE EXPECT THERE TO BE A 

680
00:34:15,360 --> 00:34:17,280
LONG-TERM NEED INCLUDING MENTAL 

681
00:34:17,280 --> 00:34:22,120
HEALTH, PEDIATRIC RESEARCH AND 

682
00:34:22,120 --> 00:34:24,880
COMMUNITY ENGAGEMENT I 

683
00:34:24,880 --> 00:34:26,480
APPRECIATE CONGRESS WAS ABLE TO 

684
00:34:26,480 --> 00:34:28,720
SUPPORT THOSE AND WE'LL SEEK 

685
00:34:28,720 --> 00:34:31,120
ADDITIONAL FUNDS FOR THOSE 

686
00:34:31,120 --> 00:34:32,240
PRIORITIES INCLUDING BUILDING 

687
00:34:32,240 --> 00:34:34,080
AND FACILITIES WHICH HAS BEEN A 

688
00:34:34,080 --> 00:34:44,560
GREAT LONG-TERM NEED FOR NIH.

689
00:34:45,960 --> 00:34:50,080
THE PRESIDENT'S BUDGET WAS ALSO 

690
00:34:50,080 --> 00:34:50,320
DELAYED.

691
00:34:50,320 --> 00:34:51,760
THEY WERE HOPING FOR 

692
00:34:51,760 --> 00:34:52,480
CONGRESSIONAL APPROPRIATIONS 

693
00:34:52,480 --> 00:34:55,160
ACTION IN TIME TO FACTOR THEM IN

694
00:34:55,160 --> 00:34:57,320
THE '23 REQUEST.

695
00:34:57,320 --> 00:34:58,440
ULTIMATELY THAT WASN'T POSSIBLE.

696
00:34:58,440 --> 00:35:02,320
THE APPROPRIATION CAME TOO LATE 

697
00:35:02,320 --> 00:35:04,480
IN THE YEAR AND THE BUDGET HAD 

698
00:35:04,480 --> 00:35:07,880
TO BE DEVELOPED ASSUMING THE 

699
00:35:07,880 --> 00:35:10,600
CONTINUING RESOLUTION AND FLAT 

700
00:35:10,600 --> 00:35:15,120
LEVEL FOR 2022 AS IT TURNED OUT 

701
00:35:15,120 --> 00:35:16,920
PASSING THE OMNIBUS TWO WEEKS 

702
00:35:16,920 --> 00:35:20,760
BEFORE THE BUDGET WAS RELEASED 

703
00:35:20,760 --> 00:35:21,960
BUT BECAUSE IT TAKES ABOUT 

704
00:35:21,960 --> 00:35:23,480
MONTHS OR MORE TO DEVELOP THE 

705
00:35:23,480 --> 00:35:25,000
BUDGET IT WASN'T ENOUGH TIME TO 

706
00:35:25,000 --> 00:35:28,040
PIVOT AND TO BE ABLE TO BASE THE

707
00:35:28,040 --> 00:35:31,040
BUDGET OFF THE ENACTED 

708
00:35:31,040 --> 00:35:34,680
APPROPRIATION RATHER THAN THE 

709
00:35:34,680 --> 00:35:35,560
CONTINUING RESOLUTION.

710
00:35:35,560 --> 00:35:38,840
THAT'S CREATED A FAIR BIT OF 

711
00:35:38,840 --> 00:35:41,720
CONFUSION WHEN YOU COMPARE THE 

712
00:35:41,720 --> 00:35:43,200
'22 BUDGET TO THE APPROPRIATION.

713
00:35:43,200 --> 00:35:45,880
IT DOESN'T REALLY SHOW YOU WHAT 

714
00:35:45,880 --> 00:35:47,160
THE ADMINISTRATION WAS TRYING TO

715
00:35:47,160 --> 00:35:49,800
DO WHEN IT WASN'T CONSIDERING 

716
00:35:49,800 --> 00:35:51,000
THE APPROPRIATION LEVEL FOR '22.

717
00:35:51,000 --> 00:35:55,160
TO GIVE AN EXAMPLE, IF YOU LOOK 

718
00:35:55,160 --> 00:35:59,600
AT OUR PROGRAM LEVEL WITH A 

719
00:35:59,600 --> 00:36:00,760
$16.3 BILLION INCREASE, YOU CAN 

720
00:36:00,760 --> 00:36:05,800
SEE HERE, MOST OF THAT WASES OF 

721
00:36:05,800 --> 00:36:07,120
THE RESULT OF REQUESTED 

722
00:36:07,120 --> 00:36:09,920
INCREASES FOR ARPA-H AND FOR A 

723
00:36:09,920 --> 00:36:10,600
PANDEMIC PREPAREDNESS PROPOSAL 

724
00:36:10,600 --> 00:36:14,640
I'LL TALK ABOUT IN A MINUTE.

725
00:36:14,640 --> 00:36:18,200
THE REMAINING INCREASE OF ABOUT 

726
00:36:18,200 --> 00:36:24,640
$270 MILLION IS A NET LEVEL.

727
00:36:24,640 --> 00:36:29,400
WHEN YOU CONSIDER WHEN YOU 

728
00:36:29,400 --> 00:36:30,200
COMPARE THE BUDGET TO THE 

729
00:36:30,200 --> 00:36:31,520
ENACTED LEVEL, SOME WERE 

730
00:36:31,520 --> 00:36:34,720
INCREASES, SOME WERE DECREASES 

731
00:36:34,720 --> 00:36:39,640
COMPARED TO THE OMNIBUS 

732
00:36:39,640 --> 00:36:40,880
APPROPRIATION WHERE BASED ON THE

733
00:36:40,880 --> 00:36:42,080
BUDGET ON THE CONTINUING 

734
00:36:42,080 --> 00:36:46,840
RESOLUTION ALL INTENDED TO BE 

735
00:36:46,840 --> 00:36:47,680
INCREASES.

736
00:36:47,680 --> 00:36:49,600
IT'S A LITTLE DIFFICULT TO 

737
00:36:49,600 --> 00:36:56,800
COMPARE '23 TO '22 AS A RESULT 

738
00:36:56,800 --> 00:36:58,960
OF THAT BUT WE'LL BE ABLE TO 

739
00:36:58,960 --> 00:37:01,120
BUILD ON THAT FOR 23.

740
00:37:01,120 --> 00:37:07,080
GOING ON TO THE NEXT SLIDE AS 

741
00:37:07,080 --> 00:37:08,240
INTENDED IN THE PRESIDENT'S 

742
00:37:08,240 --> 00:37:09,600
BUDGET, THERE WAS A GENERAL 

743
00:37:09,600 --> 00:37:12,280
INCREASE OF 2% OVER THE 

744
00:37:12,280 --> 00:37:14,680
CONTINUING RESOLUTION AT THE 

745
00:37:14,680 --> 00:37:18,920
LOWER LEVEL FOR ALL THE 

746
00:37:18,920 --> 00:37:19,720
INSTITUTES AND CENTERS AS WELL 

747
00:37:19,720 --> 00:37:21,240
AS RESEARCH INITIATIVES IN THE 

748
00:37:21,240 --> 00:37:23,320
PRESIDENT'S BUDGET WHERE WE WERE

749
00:37:23,320 --> 00:37:24,440
SEEKING SPECIFIC INCREASES AND 

750
00:37:24,440 --> 00:37:33,480
THE LARGEST ONES ARE NOTED HERE 

751
00:37:33,480 --> 00:37:37,200
MANY BUILDING ON THE '22 REQUEST

752
00:37:37,200 --> 00:37:40,040
INCLUDING THE OPIOIDS PAIN 

753
00:37:40,040 --> 00:37:42,760
RESEARCH AND THE HEAL INITIATIVE

754
00:37:42,760 --> 00:37:44,440
IN THE CYBER SECURITY AND 

755
00:37:44,440 --> 00:37:45,600
BUILDING FACILITIES.

756
00:37:45,600 --> 00:37:48,200
IN EACH CASE THE REQUEST IN THE 

757
00:37:48,200 --> 00:37:50,680
BUDGET WAS SOMEWHAT LARGER BUT 

758
00:37:50,680 --> 00:37:52,480
WE ACCOUNTED FOR THE AMOUNT 

759
00:37:52,480 --> 00:37:54,920
CONGRESS DID PROVIDE IN '22 

760
00:37:54,920 --> 00:37:56,520
WITHIN THAT INITIAL REQUEST.

761
00:37:56,520 --> 00:37:58,600
SO WE'RE HOPING THEY WILL 

762
00:37:58,600 --> 00:38:00,760
SUPPORT THESE PRIORITIES 

763
00:38:00,760 --> 00:38:02,360
ADDITIONALLY IN FY23 ON TOP OF 

764
00:38:02,360 --> 00:38:05,960
WHAT THEY WERE ABLE TO PROVIDE 

765
00:38:05,960 --> 00:38:08,920
US IN 2022.

766
00:38:08,920 --> 00:38:12,880
WE HAVE INITIATIVES FOR CLIMATE 

767
00:38:12,880 --> 00:38:14,040
RESEARCH AND HAVE A STRATEGIC 

768
00:38:14,040 --> 00:38:15,880
PLAN FOR NUTRITION SCIENCE WE'RE

769
00:38:15,880 --> 00:38:17,080
HOPING TO SUPPORT WITH 

770
00:38:17,080 --> 00:38:19,680
ADDITIONAL FUNDING IN 2023.

771
00:38:19,680 --> 00:38:23,680
THOSE ARE SOME NEW PRIORITIES 

772
00:38:23,680 --> 00:38:25,080
FOR WHICH WE DIDN'T GET 

773
00:38:25,080 --> 00:38:35,360
INCREASES IN 2022.

774
00:38:38,320 --> 00:38:40,840
THIS IS A MANDATORY PROPOSAL NOT

775
00:38:40,840 --> 00:38:42,920
PART OF THE PROCESS.

776
00:38:42,920 --> 00:38:44,120
ONE-TIME FUNDING AVAILABLE FOR 

777
00:38:44,120 --> 00:38:48,160
FIVE YEARS.

778
00:38:48,160 --> 00:38:52,200
THE REQUEST OF A HEALTH AND 

779
00:38:52,200 --> 00:38:55,440
HUMAN SERVICES PROPOSAL IS $82 

780
00:38:55,440 --> 00:38:56,720
BILLION IN TOTAL BUT THE 

781
00:38:56,720 --> 00:38:58,960
RESEARCH COMPONENT IS AN 

782
00:38:58,960 --> 00:39:00,240
IMPORTANT PART OF THAT.

783
00:39:00,240 --> 00:39:05,200
TO GIVE YOU AN IDEA OF WHAT IS 

784
00:39:05,200 --> 00:39:08,440
INCLUDED, THE PRE-CLINICAL
R&D.

785
00:39:08,440 --> 00:39:12,200
THE IDEA IS TO FOCUS ON 20 HIGH 

786
00:39:12,200 --> 00:39:13,600
PROFILE VIRAL FAMILIES CHOOSE 

787
00:39:13,600 --> 00:39:16,040
REPRESENTATIVE VIRUSES FOR THOSE

788
00:39:16,040 --> 00:39:20,040
FAMILIES THAT WE CAN RESEARCH.

789
00:39:20,040 --> 00:39:22,640
THEN THE SECOND EXPANDING 

790
00:39:22,640 --> 00:39:23,280
LABORATORY CAPACITY WHERE THERE 

791
00:39:23,280 --> 00:39:25,600
ARE GAPS DOUBLING THE ABILITY OF

792
00:39:25,600 --> 00:39:27,640
THE VACCINE RESEARCH CENTER TO 

793
00:39:27,640 --> 00:39:29,320
DO PILOT LOT MANUFACTURING.

794
00:39:29,320 --> 00:39:31,560
THE THIRD WOULD BE THE 

795
00:39:31,560 --> 00:39:32,160
DEVELOPMENT AND CLINICAL 

796
00:39:32,160 --> 00:39:34,160
EVALUATION OF VACCINES AND 

797
00:39:34,160 --> 00:39:34,600
THERAPEUTICS.

798
00:39:34,600 --> 00:39:37,640
THE NEXT STEP IN CLINICAL 

799
00:39:37,640 --> 00:39:37,960
RESEARCH.

800
00:39:37,960 --> 00:39:41,960
THIS WOULD INCLUDE HOST-TARGETED

801
00:39:41,960 --> 00:39:42,280
THERAPEUTICS.

802
00:39:42,280 --> 00:39:45,320
THE NEXT IS ESTABLISHING OR 

803
00:39:45,320 --> 00:39:46,960
EXPANDING CLINICAL TRIALS 

804
00:39:46,960 --> 00:39:47,200
NETWORKS.

805
00:39:47,200 --> 00:39:48,320
THIS WAS CRUCIAL FOR US DEALING 

806
00:39:48,320 --> 00:39:53,680
WITH COVID WE WERE ABLE TO BUILD

807
00:39:53,680 --> 00:39:55,320
ON EXISTING CLINICAL TRIALS 

808
00:39:55,320 --> 00:40:00,480
NETWORKS AND THIS FUNDING ALLOWS

809
00:40:00,480 --> 00:40:04,640
THEM TO BE USED BEYOND COVID.

810
00:40:04,640 --> 00:40:08,400
BIOSAFETY AND BIOSECURITY WITH 

811
00:40:08,400 --> 00:40:13,160
FUNDING FOR BSL3 AND 4 LABS FOR 

812
00:40:13,160 --> 00:40:14,080
HIGHER SECURITY AND ADDITIONAL 

813
00:40:14,080 --> 00:40:17,360
DIAGNOSTICS AND INNOVATIONS.

814
00:40:17,360 --> 00:40:21,680
THIS WOULD BUILD ON THE RADX 

815
00:40:21,680 --> 00:40:23,680
TECH PROGRAM TO EXTEND BEYOND 

816
00:40:23,680 --> 00:40:24,080
COVID.

817
00:40:24,080 --> 00:40:27,560
OVER ALL A VERY COMPREHENSIVE 

818
00:40:27,560 --> 00:40:29,160
PROPOSAL THAT WOULD PUT US IN 

819
00:40:29,160 --> 00:40:30,840
BETTER SHAPE TO DEAL WITH THE 

820
00:40:30,840 --> 00:40:32,000
NEXT PANDEMIC THAT HOPEFULLY 

821
00:40:32,000 --> 00:40:34,920
WILL BE FAR OFF BUT WE COULD BE 

822
00:40:34,920 --> 00:40:37,280
MUCH BETTER PREPARED.

823
00:40:37,280 --> 00:40:39,200
WITH THAT, I WILL STOP.

824
00:40:39,200 --> 00:40:44,480
>> AT THIS POINT I DON'T
KNOW IF

825
00:40:44,480 --> 00:40:47,320
WE SHOULD PROCEED THROUGH WITH 

826
00:40:47,320 --> 00:40:49,040
ADRIENNE'S AND PROCEED THROUGH 

827
00:40:49,040 --> 00:40:50,440
WITH BOTH OR DOES ANYONE HAVE 

828
00:40:50,440 --> 00:40:52,720
QUESTIONS THEY'D LIKE TO ADDRESS

829
00:40:52,720 --> 00:40:55,440
TO NEIL AT THIS POINT.

830
00:40:55,440 --> 00:40:58,960
USE THE RAISE THE HAND FEATURE 

831
00:40:58,960 --> 00:41:00,560
OR PUT SOMETHING IN THE CHAT 

832
00:41:00,560 --> 00:41:02,040
BOX, WE CAN FIND YOU.

833
00:41:02,040 --> 00:41:04,440
>> I'LL GRAB THE MIC AND
SKIP 

834
00:41:04,440 --> 00:41:05,680
THE PROCESS.

835
00:41:05,680 --> 00:41:07,840
NEIL, I'M CURIOUS IN PARTICULAR 

836
00:41:07,840 --> 00:41:09,280
ABOUT THE PANDEMIC PREP PIECE 

837
00:41:09,280 --> 00:41:11,520
WHICH IS A SIGNIFICANT NEW AND 

838
00:41:11,520 --> 00:41:12,120
IMPORTANT INITIATIVE.

839
00:41:12,120 --> 00:41:15,400
WHAT THE TIME LINE IS FOR THAT 

840
00:41:15,400 --> 00:41:16,720
PIECE IN PARTICULAR TO GET MORE 

841
00:41:16,720 --> 00:41:20,360
CLARITY ON HOW IT MOVES FROM 

842
00:41:20,360 --> 00:41:21,720
PRESIDENT'S BUDGET TO ACTUAL 

843
00:41:21,720 --> 00:41:23,160
LEGISLATIVE DISCUSSION TO 

844
00:41:23,160 --> 00:41:23,480
APPROVAL.

845
00:41:23,480 --> 00:41:27,200
WHEN WILL THAT GET CLEARER?

846
00:41:27,200 --> 00:41:29,720
>> I THINK ADRIENNE CAN
PROBABLY

847
00:41:29,720 --> 00:41:34,040
GIVE YOU A BETTER IDEA OF THE 

848
00:41:34,040 --> 00:41:37,720
TIMING BUT BECAUSE IT'S 

849
00:41:37,720 --> 00:41:39,120
MANDATORY IT WOULD RELY ON 

850
00:41:39,120 --> 00:41:40,280
AUTHORIZING COMMITTEES IN 

851
00:41:40,280 --> 00:41:42,720
CONGRESS TO TAKE IT UP AND MOVE 

852
00:41:42,720 --> 00:41:44,640
IT FORWARD.

853
00:41:44,640 --> 00:41:45,760
ADRIENNE CAN TALK MORE ABOUT 

854
00:41:45,760 --> 00:41:47,720
THAT IN HER PIECE.

855
00:41:47,720 --> 00:41:50,320
>> THE PROPOSAL HAVE A
TOUGHER 

856
00:41:50,320 --> 00:41:52,480
ROAD BECAUSE IT'S PART OF A 

857
00:41:52,480 --> 00:41:53,920
GENERAL BUDGET.

858
00:41:53,920 --> 00:41:58,800
IT'S PART OF THE $1 TRILLION 

859
00:41:58,800 --> 00:41:59,800
U.S. GOVERNMENT BUDGET.

860
00:41:59,800 --> 00:42:03,160
THERE AREN'T ASSIGNED OFFSETS.

861
00:42:03,160 --> 00:42:04,520
AUTHORIZING COMMITTEE IS THE 

862
00:42:04,520 --> 00:42:07,840
HEALTH EDUCATION, LABOR PENSIONS

863
00:42:07,840 --> 00:42:08,080
COMMITTEE.

864
00:42:08,080 --> 00:42:10,360
THEY DON'T HAVE A LOT OF FUNDED 

865
00:42:10,360 --> 00:42:10,640
PROGRAMS.

866
00:42:10,640 --> 00:42:12,080
IT'S NOT LIKE THEY CAN TAKE 

867
00:42:12,080 --> 00:42:13,360
SAVINGS SOMEWHERE ELSE SO THE 

868
00:42:13,360 --> 00:42:14,880
BUDGET COMMITTEE HAS TO GIVE 

869
00:42:14,880 --> 00:42:20,320
THEM AN ALLOCATION FROM SOME 

870
00:42:20,320 --> 00:42:23,480
OTHER COMMITTEE IT LET'S A 

871
00:42:23,480 --> 00:42:24,480
LITTLE FRAUGHT.

872
00:42:24,480 --> 00:42:26,040
THERE'S LEGISLATION MOVING RIGHT

873
00:42:26,040 --> 00:42:26,520
NOW.

874
00:42:26,520 --> 00:42:31,960
THERE'S NO ACTUAL MONEY ATTACHED

875
00:42:31,960 --> 00:42:34,800
TO IT.

876
00:42:34,800 --> 00:42:36,440
WE HAVE YET TO SEE IF IT WILL 

877
00:42:36,440 --> 00:42:40,560
GET TRACTION.

878
00:42:40,560 --> 00:42:42,960
>>  I WAS INTERESTED IN
SEEING 

879
00:42:42,960 --> 00:42:45,320
ALL THE CYBER SECURITY FUNDING 

880
00:42:45,320 --> 00:42:45,640
ASSOCIATED.

881
00:42:45,640 --> 00:42:47,400
I WAS CURIOUS, IS THAT MOSTLY 

882
00:42:47,400 --> 00:42:50,000
ABOUT PREVENTIVE, 

883
00:42:50,000 --> 00:42:50,640
INFRASTRUCTURE, STRENGTHENING 

884
00:42:50,640 --> 00:42:53,200
PROCESSES AND SYSTEMS AROUND 

885
00:42:53,200 --> 00:42:55,360
SENSITIVE DATA OR IS IT ALSO 

886
00:42:55,360 --> 00:42:57,560
ABOUT RESEARCH OR BOTH?

887
00:42:57,560 --> 00:43:04,920
>> THAT WOULD BE ABOUT
BOTH.

888
00:43:04,920 --> 00:43:08,080
>> HEAVY EMPHASIS ON THE
FORMER 

889
00:43:08,080 --> 00:43:13,960
AND TARA SCHWETZ WILL GIVE AN 

890
00:43:13,960 --> 00:43:15,680
ENTIRE PRESENTATION ON ARPA-H.

891
00:43:15,680 --> 00:43:17,880
IF WE CAN POSTPONE THAT THAT 

892
00:43:17,880 --> 00:43:19,080
WOULD BE THE BEST.

893
00:43:19,080 --> 00:43:20,200
ANY OTHER QUESTIONS AT THIS 

894
00:43:20,200 --> 00:43:23,360
POINT BEFORE WE MOVE ON TO THE 

895
00:43:23,360 --> 00:43:23,880
LEGISLATIVE -- 

896
00:43:23,880 --> 00:43:29,960
>> IS THE CHAT ABOUT
ARPA-H?

897
00:43:29,960 --> 00:43:32,400
>> WE'LL HAVE AN ENTIRE 

898
00:43:32,400 --> 00:43:33,880
PRESENTATION AND LET'S DELAY 

899
00:43:33,880 --> 00:43:35,840
THAT QUESTION AND ANSWER UNTIL 

900
00:43:35,840 --> 00:43:46,280
WE HEAR THE PRESENTATION.

901
00:43:49,800 --> 00:43:54,480
ADRIENNE, PLEASE.

902
00:43:54,480 --> 00:43:57,520
>> THANK YOU.

903
00:43:57,520 --> 00:44:01,600
DR. TABAK GAVE THE BIRD'S-EYE 

904
00:44:01,600 --> 00:44:03,320
VIEW AND THIS IS CLOSER UP SO 

905
00:44:03,320 --> 00:44:05,480
YOU KNOW WE HAVE A NUMBER OF 

906
00:44:05,480 --> 00:44:06,800
INSTITUTE DIRECTORS ON THE HOT 

907
00:44:06,800 --> 00:44:07,120
SEAT.

908
00:44:07,120 --> 00:44:11,520
I THOUGHT IT WOULD BE HELPFUL TO

909
00:44:11,520 --> 00:44:13,680
TALK ABOUT A COUPLE THEMES AND 

910
00:44:13,680 --> 00:44:16,760
EVERYONE'S ASKING QUESTIONS 

911
00:44:16,760 --> 00:44:17,320
ABOUT ARPA-H.

912
00:44:17,320 --> 00:44:19,240
WE'RE STILL IN THIS PANDEMIC, 

913
00:44:19,240 --> 00:44:19,640
POST-

914
00:44:19,640 --> 00:44:24,120
AND ARE WE POST-PANDEMIC AND 

915
00:44:24,120 --> 00:44:26,080
CONGRESS IS THERE WITH US AND 

916
00:44:26,080 --> 00:44:27,720
THEY'RE ASKING ABOUT LONG COVID 

917
00:44:27,720 --> 00:44:31,520
AND ABOUT MENTAL HEALTH, SCHOOL 

918
00:44:31,520 --> 00:44:33,200
CLOSURES, MASK POLICIES.

919
00:44:33,200 --> 00:44:35,160
THERE'S STARTING TO BE A GLIMMER

920
00:44:35,160 --> 00:44:40,360
OF LIFE AFTER PANDEMIC GETTING 

921
00:44:40,360 --> 00:44:46,160
BACK TO WHAT IS THE FUTURE OF 

922
00:44:46,160 --> 00:44:49,200
THE UNDIAGNOSED DISEASES AND 

923
00:44:49,200 --> 00:44:51,440
SUCCESS RATE DRIVEN A LOT BY NCI

924
00:44:51,440 --> 00:44:58,320
AND ALZHEIMER'S, ETCETERA.

925
00:44:58,320 --> 00:44:59,600
THAT'S TRUE NOT JUST IN 

926
00:44:59,600 --> 00:45:00,080
APPROPRIATIONS.

927
00:45:00,080 --> 00:45:05,120
IN 2020 IT WAS COVID.

928
00:45:05,120 --> 00:45:07,680
WE DID A NUMBER OF EVENTS AND 

929
00:45:07,680 --> 00:45:10,480
THERE WASN'T A LOT IN PERSON.

930
00:45:10,480 --> 00:45:13,640
IN 2021, COVID GOT MORE GRANULAR

931
00:45:13,640 --> 00:45:17,800
WHERE IT WAS COVID OR IT WAS 

932
00:45:17,800 --> 00:45:21,720
WHAT IS HAPPENING WITH DIVERSITY

933
00:45:21,720 --> 00:45:25,200
IN CLINICAL TRIALS AND RADX.

934
00:45:25,200 --> 00:45:26,680
EVERYTHING HAD A COVID 

935
00:45:26,680 --> 00:45:27,000
CONNECTION.

936
00:45:27,000 --> 00:45:31,840
2022 WE'RE STARTING TO SEE 

937
00:45:31,840 --> 00:45:35,080
PEOPLE RESUME THEY'RE MORE 

938
00:45:35,080 --> 00:45:36,320
TRADITIONAL PRIORITIES.

939
00:45:36,320 --> 00:45:39,080
THEY'RE STILL INTERESTED IN 

940
00:45:39,080 --> 00:45:41,400
COVID-19 BUT INTERESTED IN ALS 

941
00:45:41,400 --> 00:45:42,080
RESEARCH AND WOMEN'S HEALTH AND 

942
00:45:42,080 --> 00:45:50,760
OTHER THINGS.

943
00:45:50,760 --> 00:45:52,480
THAT'S STARTING TO RETURN AND 

944
00:45:52,480 --> 00:45:55,040
IT'S A NICE REFRESHER THOUGH WE 

945
00:45:55,040 --> 00:45:57,200
WERE ALL IN ON COVID THE REST OF

946
00:45:57,200 --> 00:45:58,880
THE RESEARCH COMMUNITY DID NOT 

947
00:45:58,880 --> 00:45:59,000
SO

948
00:45:59,000 --> 00:45:59,160
.

949
00:45:59,160 --> 00:46:01,240
AS DR. TABAK MENTIONED AND 

950
00:46:01,240 --> 00:46:08,120
YOU'LL GET A LARGER PRESENTATION

951
00:46:08,120 --> 00:46:11,720
LATER, WE'RE LEGISLATION TO 

952
00:46:11,720 --> 00:46:13,280
REQUIRE NOTIFICATION BY 

953
00:46:13,280 --> 00:46:14,480
NIH-FUNDED INSTITUTIONS WITHIN 

954
00:46:14,480 --> 00:46:16,960
30 DAYS OF REMOVING OR 

955
00:46:16,960 --> 00:46:17,440
DISCIPLINARY ACTION.

956
00:46:17,440 --> 00:46:22,000
THIS CAME ABOUT AS PART OF THE 

957
00:46:22,000 --> 00:46:23,120
DISCUSSION AROUND SEXUAL 

958
00:46:23,120 --> 00:46:24,240
HARASSMENT BUT IT'S IMPORTANT TO

959
00:46:24,240 --> 00:46:27,000
NOTE THIS LANGUAGE DOES NOT SAY 

960
00:46:27,000 --> 00:46:28,200
JUST SEXUAL HARASSMENT.

961
00:46:28,200 --> 00:46:31,000
THIS IS HARASSMENT, BULLYING, 

962
00:46:31,000 --> 00:46:32,520
RETALIATION, HOSTILE WORK 

963
00:46:32,520 --> 00:46:37,400
ENVIRONMENT.

964
00:46:37,400 --> 00:46:39,520
WE'RE TAKING A MORE BROAD 

965
00:46:39,520 --> 00:46:40,480
APPROACH TO THIS AS APPROPRIATE.

966
00:46:40,480 --> 00:46:44,480
WE'RE ALSO IMPLEMENTING THE ACT 

967
00:46:44,480 --> 00:46:47,960
FOR ALS WHICH WAS ENACTED 

968
00:46:47,960 --> 00:46:48,720
RECENTLY.

969
00:46:48,720 --> 00:46:50,760
WE WERE ASKED IN THE OMNIBUS TO 

970
00:46:50,760 --> 00:46:51,720
SPEND $25 MILLION IMPLEMENTING 

971
00:46:51,720 --> 00:46:56,360
THE POLICY.

972
00:46:56,360 --> 00:46:57,640
THERE'S FIVE SECTIONS TO THE 

973
00:46:57,640 --> 00:46:58,040
ACT.

974
00:46:58,040 --> 00:47:02,520
TWO ARE IMPORTANT TO NIH.

975
00:47:02,520 --> 00:47:05,120
ONE IS A PUBLIC-PRIVATE 

976
00:47:05,120 --> 00:47:06,800
PARTNERSHIP AND THE SECOND IS A 

977
00:47:06,800 --> 00:47:08,040
GRANTS PROGRAM.

978
00:47:08,040 --> 00:47:10,440
A NEW GRANTS PROGRAM FOR 

979
00:47:10,440 --> 00:47:12,040
EXPANDED ACCESS TO 

980
00:47:12,040 --> 00:47:13,200
INVESTIGATIONAL DRUGS.

981
00:47:13,200 --> 00:47:15,960
ASKING US TO COLLECT DATA FROM 

982
00:47:15,960 --> 00:47:17,440
EXPANDED ACCESS.

983
00:47:17,440 --> 00:47:19,320
IT'S A BIT OF A NEW TAKE FOR US 

984
00:47:19,320 --> 00:47:21,320
AND IT'S A VERY COMPLICATED 

985
00:47:21,320 --> 00:47:21,600
SPACE.

986
00:47:21,600 --> 00:47:24,720
THE BILL IS LIMITED TO SMALL 

987
00:47:24,720 --> 00:47:26,960
BUSINESSES UNDER THE SPIR 

988
00:47:26,960 --> 00:47:27,520
DEFINITION.

989
00:47:27,520 --> 00:47:28,760
WE'RE RUNNING PHASE 3 CLINICAL 

990
00:47:28,760 --> 00:47:29,360
TRIALS.

991
00:47:29,360 --> 00:47:34,680
IT'S A VERY INTRICATE POLICY 

992
00:47:34,680 --> 00:47:35,560
SPACE BUT THERE'S MORE TO COME 

993
00:47:35,560 --> 00:47:43,640
ON THIS.

994
00:47:43,640 --> 00:47:46,680
I LIKE TO FLAG THINGS TO WATCH 

995
00:47:46,680 --> 00:47:49,680
AND THIS IS WHAT WHEN DR. TABAK 

996
00:47:49,680 --> 00:47:52,560
IS UP AT NIGHT, THIS KEEPS ME UP

997
00:47:52,560 --> 00:47:53,440
AT NIGHT.

998
00:47:53,440 --> 00:47:54,800
FOR A FEW YEARS NOW WE HEARD 

999
00:47:54,800 --> 00:47:57,320
FROM THE LEFT, THE DEMOCRATS, 

1000
00:47:57,320 --> 00:48:03,160
THERE'S AN INTEREST AT NIH USING

1001
00:48:03,160 --> 00:48:03,960
MARGIN TO ADDRESS DRUG PRICING.

1002
00:48:03,960 --> 00:48:08,080
WE'RE STARTING TO HEAR FROM THE 

1003
00:48:08,080 --> 00:48:09,680
RIGHT THERE'S AN INTEREST IN 

1004
00:48:09,680 --> 00:48:11,280
ROYALTIES PAID TO SCIENTISTS 

1005
00:48:11,280 --> 00:48:15,880
USING FEDERAL FUNDS.

1006
00:48:15,880 --> 00:48:17,000
QUESTIONS ON WHAT'S THE 

1007
00:48:17,000 --> 00:48:19,320
APPROPRIATE LEVEL OF THOSE 

1008
00:48:19,320 --> 00:48:19,760
ROYALTIES.

1009
00:48:19,760 --> 00:48:21,480
WHERE SHOULD THEY BE GOING AND 

1010
00:48:21,480 --> 00:48:22,040
USED FOR.

1011
00:48:22,040 --> 00:48:26,000
SINCE WE'RE NOW SEEING FROM THE 

1012
00:48:26,000 --> 00:48:32,240
LEFT AND RIGHT BOTH YOUGROUPS 

1013
00:48:32,240 --> 00:48:34,600
SAYING SHOULD WE AMEND THE 

1014
00:48:34,600 --> 00:48:38,160
POLICIES?

1015
00:48:38,160 --> 00:48:43,000
THERE'S MOMENTUM.

1016
00:48:43,000 --> 00:48:45,920
IT'S NOT BIG YET BUT WE'RE 

1017
00:48:45,920 --> 00:48:48,320
WATCHING THE SPACE AND SOMETHING

1018
00:48:48,320 --> 00:48:50,440
PROFESSIONAL SOCIETIES ARE 

1019
00:48:50,440 --> 00:48:50,840
WATCHING.

1020
00:48:50,840 --> 00:48:51,520
FUTURE FORECAST.

1021
00:48:51,520 --> 00:48:56,720
THIS IS GOING TO BE A TIGHT 

1022
00:48:56,720 --> 00:48:57,680
YEAR.

1023
00:48:57,680 --> 00:48:59,720
WE'LL TALK ABOUT WHAT THE 

1024
00:48:59,720 --> 00:49:01,040
CALENDAR LOOKS LIKE AND WHAT 

1025
00:49:01,040 --> 00:49:02,560
MIGHT HAPPEN.

1026
00:49:02,560 --> 00:49:05,720
THIS YEAR THERE'S TWO BIG 

1027
00:49:05,720 --> 00:49:06,080
EXPLORATIONS.

1028
00:49:06,080 --> 00:49:07,960
FDA USER FEES.

1029
00:49:07,960 --> 00:49:11,280
THIS IS HOW FDA THEIR WORK.

1030
00:49:11,280 --> 00:49:13,840
THESE ARE FEE-AUTHORITY EXPIRES 

1031
00:49:13,840 --> 00:49:15,920
SEPTEMBER 30, TO NOT LAYOFF 

1032
00:49:15,920 --> 00:49:17,920
STAFF THEY HAVE TO KNOW WELL 

1033
00:49:17,920 --> 00:49:20,040
BEFORE SEPTEMBER 30.

1034
00:49:20,040 --> 00:49:22,480
THE FDA USER FEE LEGISLATION IS 

1035
00:49:22,480 --> 00:49:22,880
MOVING NOW.

1036
00:49:22,880 --> 00:49:27,440
BECAUSE IT'S A MUST-PASS BILL IT

1037
00:49:27,440 --> 00:49:29,160
MAY HAVE PROVISIONS PEOPLE 

1038
00:49:29,160 --> 00:49:30,680
ATTACH BECAUSE THEY KNOW THE 

1039
00:49:30,680 --> 00:49:33,560
USER FEES WILL MAKE IT TO THE 

1040
00:49:33,560 --> 00:49:34,600
PRESIDENT'S DESK.

1041
00:49:34,600 --> 00:49:35,960
OUR PROGRAMS ARE SUN SETTING AT 

1042
00:49:35,960 --> 00:49:39,960
THE END OF THE FISCAL YEAR, 

1043
00:49:39,960 --> 00:49:40,960
SEPTEMBER 30.

1044
00:49:40,960 --> 00:49:43,840
WE'LL MAKE ALL OUR AWARDS UNDER 

1045
00:49:43,840 --> 00:49:46,440
EXISTING POLICIES.

1046
00:49:46,440 --> 00:49:48,440
WE'RE LOOKING TO SEE WHETHER 

1047
00:49:48,440 --> 00:49:51,000
THERE WILL BE CHANGES.

1048
00:49:51,000 --> 00:49:53,600
I DON'T KNOW IF PEOPLE STOP 

1049
00:49:53,600 --> 00:49:56,040
FUNDING IN AN ELECTION YEAR BUT 

1050
00:49:56,040 --> 00:49:57,880
IT'S SOMETHING WE'RE TAKING A 

1051
00:49:57,880 --> 00:49:58,720
LOOK AT.

1052
00:49:58,720 --> 00:50:00,880
APPROPRIATIONS HAVE TO GET DONE.

1053
00:50:00,880 --> 00:50:05,560
THERE'S AN ANNUAL DEFENSE 

1054
00:50:05,560 --> 00:50:08,280
AUTHORIZATION AND ALSO IN ONE OF

1055
00:50:08,280 --> 00:50:13,920
THE COVID BILLS THERE WAS A 

1056
00:50:13,920 --> 00:50:15,360
SUPPLEMENTAL SUBSIDY FOR 

1057
00:50:15,360 --> 00:50:17,200
INCREASES TO PREMIUMS.

1058
00:50:17,200 --> 00:50:19,960
THAT IS EXPIRING.

1059
00:50:19,960 --> 00:50:22,040
WITHOUT AN EXTENSION THERE COULD

1060
00:50:22,040 --> 00:50:26,040
BE A DRAMATIC INCREASE IN 

1061
00:50:26,040 --> 00:50:26,400
PREMIUMS.

1062
00:50:26,400 --> 00:50:27,880
THOSE ARE SOME PROVISION WILL 

1063
00:50:27,880 --> 00:50:33,440
HAVE TO PASS THIS YEAR.

1064
00:50:33,440 --> 00:50:34,920
IN THE MIDST OF THAT THERE'S 

1065
00:50:34,920 --> 00:50:36,240
LEGISLATION SWIRLING THAT MIGHT 

1066
00:50:36,240 --> 00:50:37,960
PASS AND MAY GET ATTACHED TO THE

1067
00:50:37,960 --> 00:50:38,480
MUST PASS.

1068
00:50:38,480 --> 00:50:42,600
THINGS WE CARE ABOUT AND WE'RE 

1069
00:50:42,600 --> 00:50:43,480
WATCHING THE ARPA-H 

1070
00:50:43,480 --> 00:50:43,800
AUTHORIZATION.

1071
00:50:43,800 --> 00:50:46,960
SOME SORT OF HEALTH OMNIBUS, 

1072
00:50:46,960 --> 00:50:49,840
PANDEMIC PREPAREDNESS, CURES 

1073
00:50:49,840 --> 00:50:50,680
2.0.

1074
00:50:50,680 --> 00:50:52,440
A LOT OF THAT HAS TO DO WITH 

1075
00:50:52,440 --> 00:50:57,040
THERE'S A LOT OF PRESSURE RIGHT 

1076
00:50:57,040 --> 00:51:02,600
NOW TO EXPAND THE POLICIES 

1077
00:51:02,600 --> 00:51:04,600
AROUND TELEHEALTH AND REMOTE 

1078
00:51:04,600 --> 00:51:04,920
HEALTH CARE.

1079
00:51:04,920 --> 00:51:06,320
WHAT DID HEALTH CARE LOOK LIKE 

1080
00:51:06,320 --> 00:51:07,920
IN THE PANDEMIC AND WHAT ARE THE

1081
00:51:07,920 --> 00:51:10,400
LESSONS LEARNED WE CAN MAKE 

1082
00:51:10,400 --> 00:51:10,680
PERMANENT.

1083
00:51:10,680 --> 00:51:11,880
THERE'S ALL THESE THINGS THAT 

1084
00:51:11,880 --> 00:51:14,080
ARE KIND OF SWIRLING.

1085
00:51:14,080 --> 00:51:15,720
IT FEELS TO ME LIKE THIS IS ONE 

1086
00:51:15,720 --> 00:51:16,960
OF THOSE WHERE INDIVIDUAL BILLS 

1087
00:51:16,960 --> 00:51:18,840
ARE NOT GOING TO MOVE ON THEIR 

1088
00:51:18,840 --> 00:51:19,080
OWN.

1089
00:51:19,080 --> 00:51:20,960
THERE WILL BE A PACKAGE AT SOME 

1090
00:51:20,960 --> 00:51:23,520
POINT POSSIBLY MORE THAN ONE.

1091
00:51:23,520 --> 00:51:24,520
U.S. COMPETES ACT.

1092
00:51:24,520 --> 00:51:27,200
THIS IS MOSTLY AN NSF BILL.

1093
00:51:27,200 --> 00:51:29,400
THERE'S A LOT OF PRESSURE TO 

1094
00:51:29,400 --> 00:51:31,080
MOVE IT BECAUSE THERE'S MONEY TO

1095
00:51:31,080 --> 00:51:35,240
BRING THE SEMICONDUCTOR INDUSTRY

1096
00:51:35,240 --> 00:51:36,320
BACK TO SHORES.

1097
00:51:36,320 --> 00:51:40,120
THAT'S THE U.S. COMPETES ACT BUT

1098
00:51:40,120 --> 00:51:43,160
THERE ARE PROVISIONS THAT RELATE

1099
00:51:43,160 --> 00:51:44,880
TO NIH CURRENTLY IN THE SENATE 

1100
00:51:44,880 --> 00:51:46,520
VERSION OF THE COMPETE ACT AND 

1101
00:51:46,520 --> 00:51:47,560
WE'RE WATCHING THAT AS IT GETS 

1102
00:51:47,560 --> 00:51:57,320
NEGOTIATED.

1103
00:51:57,320 --> 00:52:00,760
AND A LOT OF THESE HAVE TO DO 

1104
00:52:00,760 --> 00:52:02,400
WITH POLICY MAKERS REACTING TO 

1105
00:52:02,400 --> 00:52:05,000
MANY OF THE CONTROVERSIES, MANY 

1106
00:52:05,000 --> 00:52:08,680
OF THE CONSPIRACY THEORY SWIRL 

1107
00:52:08,680 --> 00:52:12,000
DURING THE PANDEMIC.

1108
00:52:12,000 --> 00:52:12,640
THERE'S A LOT OF CONVERSATION 

1109
00:52:12,640 --> 00:52:14,720
ABOUT ENHANCED PATHOGENS AND 

1110
00:52:14,720 --> 00:52:16,600
POTENTIAL PATHOGENS.

1111
00:52:16,600 --> 00:52:22,640
I GET THAT PHRASE WRONG ALL THE 

1112
00:52:22,640 --> 00:52:23,000
TIME.

1113
00:52:23,000 --> 00:52:23,920
THERE'S CONVERSATION ABOUT 

1114
00:52:23,920 --> 00:52:28,480
INTERNATIONAL RESEARCH.

1115
00:52:28,480 --> 00:52:33,320
POSSIBLE RESTRICTIONS.

1116
00:52:33,320 --> 00:52:36,840
AND THERE'S PERMUTATIONS OF THE 

1117
00:52:36,840 --> 00:52:39,520
LANGUAGE AND WE'RE WATCHING ALL 

1118
00:52:39,520 --> 00:52:41,440
OF IT IF WE GET OUT OF THIS 

1119
00:52:41,440 --> 00:52:43,200
CALENDAR YEAR WITHOUT SOME KIND 

1120
00:52:43,200 --> 00:52:47,680
OF POLICY BEING MADE, NEXT YEAR 

1121
00:52:47,680 --> 00:52:48,800
THIS WILL COME BACK.

1122
00:52:48,800 --> 00:52:59,320
THIS WILL BE AN ONGOING THERE'S 

1123
00:53:15,120 --> 00:53:15,920
A LOT OF STEPS FROM THE POINT 

1124
00:53:15,920 --> 00:53:24,480
WHERE THE PRESIDENT ANNOUNCE D 

1125
00:53:24,480 --> 00:53:27,160
THEY HAVE TO DO MEETINGS AND 

1126
00:53:27,160 --> 00:53:33,760
THERE HAS TO BE AT LEAST TWO 

1127
00:53:33,760 --> 00:53:33,960
VOTES.

1128
00:53:33,960 --> 00:53:36,160
IF YOU LOOK AT THE CALENDAR, 

1129
00:53:36,160 --> 00:53:37,760
WE'RE IN JUNE, THE YELLOW IS 

1130
00:53:37,760 --> 00:53:39,240
WHERE BOTH THE HOUSE AND SENATE 

1131
00:53:39,240 --> 00:53:40,720
ARE IN SESSION, THE BLUE IS 

1132
00:53:40,720 --> 00:53:42,400
WHERE THE SENATE ONLY IS IN 

1133
00:53:42,400 --> 00:53:43,880
SESSION AND THE ORANGE IS WHERE 

1134
00:53:43,880 --> 00:53:46,240
ONLY THE HOUSE IS.

1135
00:53:46,240 --> 00:53:50,240
CONFIRMATION ONLY GOES TO THE 

1136
00:53:50,240 --> 00:53:50,440
SENATE.

1137
00:53:50,440 --> 00:53:52,640
WE'VE GOT TIME IN JUNE AND JULY.

1138
00:53:52,640 --> 00:53:54,800
WE DON'T HAVE ANNOUNCEMENTS FOR 

1139
00:53:54,800 --> 00:53:56,000
OSTP OR NIH.

1140
00:53:56,000 --> 00:53:59,000
ALL THOSE BILLS I WAS TALKING TO

1141
00:53:59,000 --> 00:54:00,600
YOU ABOUT BOTH BODIES HAVE TO BE

1142
00:54:00,600 --> 00:54:02,080
IN.

1143
00:54:02,080 --> 00:54:03,920
SO JUNE, JULY -- WE'RE GOING TO 

1144
00:54:03,920 --> 00:54:04,840
DO A LOT OF WORK.

1145
00:54:04,840 --> 00:54:06,640
THE CONGRESS WILL DO A LOT OF 

1146
00:54:06,640 --> 00:54:09,080
WORK IN JUNE AND JULY.

1147
00:54:09,080 --> 00:54:10,880
AUGUST THERE'S A RECESS.

1148
00:54:10,880 --> 00:54:13,080
SEPTEMBER YOU HAVE ABOUT THREE 

1149
00:54:13,080 --> 00:54:13,480
WEEKS.

1150
00:54:13,480 --> 00:54:15,000
MOSTLY THEY'LL BE WORKING ON 

1151
00:54:15,000 --> 00:54:16,200
KEEPING THE GOVERNMENT FUNCTIONS

1152
00:54:16,200 --> 00:54:18,960
BUT I THINK THE HEALTH OMNIBUS' 

1153
00:54:18,960 --> 00:54:20,040
COULD PASS IN JULY.

1154
00:54:20,040 --> 00:54:24,040
THEN YOU GET TO OCTOBER AND 

1155
00:54:24,040 --> 00:54:24,320
NOVEMBER.

1156
00:54:24,320 --> 00:54:25,760
THE SENATE SAYS THEY'LL BE IN 

1157
00:54:25,760 --> 00:54:28,280
TWO WEEKS IN OCTOBER LEADING UP 

1158
00:54:28,280 --> 00:54:29,040
TO THE ELECTION, WE'LL SEE.

1159
00:54:29,040 --> 00:54:33,520
THEY MAY HAVE TO TO GET SOME 

1160
00:54:33,520 --> 00:54:34,280
CONFIRMATIONS THROUGH.

1161
00:54:34,280 --> 00:54:35,640
IT WILL BE TIGHT.

1162
00:54:35,640 --> 00:54:37,680
IN THE FALL IN NOVEMBER, THEY'RE

1163
00:54:37,680 --> 00:54:39,080
GOING TO BE THINKING ABOUT 

1164
00:54:39,080 --> 00:54:39,960
ORGANIZING THEMSELVES FOR THE 

1165
00:54:39,960 --> 00:54:49,440
NEW CONGRESS IN JANUARY.

1166
00:54:49,440 --> 00:54:52,680
THAT BRINGS US TO THE ELECTION.

1167
00:54:52,680 --> 00:54:53,440
RETIREMENT WATCH.

1168
00:54:53,440 --> 00:54:58,040
THERE'S A NUMBER OF RETIREMENTS 

1169
00:54:58,040 --> 00:55:00,280
WHICH WAS TRUE TWO YEARS AGO.

1170
00:55:00,280 --> 00:55:01,880
WE'RE SEEING A GENERATIONAL 

1171
00:55:01,880 --> 00:55:03,360
SHIFT IN CONGRESS.

1172
00:55:03,360 --> 00:55:06,040
SO FAR 33 DEMOCRATS AND 23 

1173
00:55:06,040 --> 00:55:11,000
REPUBLICANS ANNOUNCED THEY'RE 

1174
00:55:11,000 --> 00:55:11,280
RETIRING.

1175
00:55:11,280 --> 00:55:15,760
SOME LIKE THE GENTLEMEN 

1176
00:55:15,760 --> 00:55:18,120
MENTIONED HERE ARE VERY SENIOR 

1177
00:55:18,120 --> 00:55:19,080
AND IN VERY POWERFUL POSITIONS 

1178
00:55:19,080 --> 00:55:29,360
RELATED TO NIH.

1179
00:55:32,360 --> 00:55:34,480
I'M NOT A PUNDIT SO THERE'S 

1180
00:55:34,480 --> 00:55:38,920
SMARTER PEOPLE OUT THERE BUT TO 

1181
00:55:38,920 --> 00:55:42,760
LET YOU KNOW, VOTER TURNOUT WAS 

1182
00:55:42,760 --> 00:55:44,800
ESPECIALLY HIGH IN 2018.

1183
00:55:44,800 --> 00:55:47,000
WHAT WILL HAPPEN IN 2022.

1184
00:55:47,000 --> 00:55:49,440
THESE ARE MIDTERM ELECTIONS SO 

1185
00:55:49,440 --> 00:55:53,800
TURN OUT IS A BIG PART OF THE 

1186
00:55:53,800 --> 00:55:54,200
STORY.

1187
00:55:54,200 --> 00:55:56,400
IN THE PAST YEAR THERE'S RECORD 

1188
00:55:56,400 --> 00:55:58,080
HIGH CAMPAIGN SPENDING FOR AN 

1189
00:55:58,080 --> 00:55:59,160
OFF-CYCLE YEAR.

1190
00:55:59,160 --> 00:56:01,120
NOT ONLY ARE PEOPLE RAISING 

1191
00:56:01,120 --> 00:56:03,840
MONEY IN RECORD AMOUNTS, THEY'RE

1192
00:56:03,840 --> 00:56:04,400
SPENDING MONEY IN RECORD 

1193
00:56:04,400 --> 00:56:14,520
AMOUNTS.

1194
00:56:15,320 --> 00:56:22,240
CONTROL SUP  -- IS UP FOR GAPS.

1195
00:56:22,240 --> 00:56:24,400
IF YOU LOOK AT THE LAST 15, 20 

1196
00:56:24,400 --> 00:56:26,400
YEARS, THE NUMBER OF COMPETITIVE

1197
00:56:26,400 --> 00:56:29,240
DISTRICTS IN GRAY IN THE MIDDLE 

1198
00:56:29,240 --> 00:56:31,320
HAS GONE DOWN AND DOWN.

1199
00:56:31,320 --> 00:56:34,440
THE BRIGHT COLORS ARE THE SOLID 

1200
00:56:34,440 --> 00:56:34,720
DISTRICTS.

1201
00:56:34,720 --> 00:56:36,440
THEY'RE GOING TO STAY.

1202
00:56:36,440 --> 00:56:40,760
BUT THAT MEANS THAT PRIMARIES 

1203
00:56:40,760 --> 00:56:42,600
ARE INCREDIBLY IMPORTANT.

1204
00:56:42,600 --> 00:56:43,400
EVERYBODY KNOWS THAT.

1205
00:56:43,400 --> 00:56:45,840
THIS IS JUST TO LET YOU KNOW, 

1206
00:56:45,840 --> 00:56:48,000
THE REPUBLICAN PARTY IS TARGET 

1207
00:56:48,000 --> 00:56:49,680
BEING MORE SEATS.

1208
00:56:49,680 --> 00:56:50,400
THEY'RE IN THE MINORITY IN THE 

1209
00:56:50,400 --> 00:56:51,920
HOUSE AND SENATE.

1210
00:56:51,920 --> 00:56:56,240
IT'S NOT TERRIBLY SURPRISING.

1211
00:56:56,240 --> 00:56:58,040
YOU'RE GOING TO SEE 40 SEATS ARE

1212
00:56:58,040 --> 00:57:00,520
HIGHLY COMPETITIVE AND THAT'S 

1213
00:57:00,520 --> 00:57:04,480
WHERE A LOT OF THE ATTENTION ON 

1214
00:57:04,480 --> 00:57:14,960
ELECTION NIGHT WILL BE PAID.

1215
00:57:15,880 --> 00:57:18,000
RIGHT NOW THESE ARE THE OPEN 

1216
00:57:18,000 --> 00:57:19,680
SEATS IN THE SENATE.

1217
00:57:19,680 --> 00:57:20,920
OF THOSE REQUIREMENTS, THESE ARE

1218
00:57:20,920 --> 00:57:24,840
THE ONES THAT ARE HAPPENING IN 

1219
00:57:24,840 --> 00:57:26,080
THE SENATE CLASS.

1220
00:57:26,080 --> 00:57:28,560
ONLY A THIRD OF THE SENATE IS UP

1221
00:57:28,560 --> 00:57:30,360
EVERY TWO YEARS.

1222
00:57:30,360 --> 00:57:32,080
THEIR TERMS ARE SIX YEARS.

1223
00:57:32,080 --> 00:57:36,200
DEMOCRATS ARE DEFENDING ONE 

1224
00:57:36,200 --> 00:57:36,480
SEAT.

1225
00:57:36,480 --> 00:57:40,480
THERE ARE SIX OPEN SEATS ON THE 

1226
00:57:40,480 --> 00:57:48,480
REPUBLICAN SIDE.

1227
00:57:48,480 --> 00:57:51,000
THAT'S WHAT WE'RE WATCHING FOR.

1228
00:57:51,000 --> 00:57:52,480
IT'S GOING TO BE A BUSY SUMMER 

1229
00:57:52,480 --> 00:57:56,520
AND IT'S GOING TO BE A VERY 

1230
00:57:56,520 --> 00:58:06,600
FALL.

1231
00:58:08,400 --> 00:58:09,320
>> QUESTIONS FOR ADRIENNE
AT 

1232
00:58:09,320 --> 00:58:19,520
THIS POINT?

1233
00:58:28,280 --> 00:58:30,480
I'M NOT SEEING ANY.

1234
00:58:30,480 --> 00:58:32,520
I GUESS IT WAS PERFECTLY CLEAR.

1235
00:58:32,520 --> 00:58:34,000
>> I DESERVE A RAISE.

1236
00:58:34,000 --> 00:58:41,640
>> THANK YOU, ADRIENNE AND
NEIL.

1237
00:58:41,640 --> 00:58:47,640
I'D LIKE TO GIVE YOU SOME VERY 

1238
00:58:47,640 --> 00:58:52,400
RAPID UPDATES AND SAMPLING OF 

1239
00:58:52,400 --> 00:58:52,920
INITIATIVES THAT NIH HAS 

1240
00:58:52,920 --> 00:59:02,560
UNDERTAKEN.

1241
00:59:02,560 --> 00:59:04,720
FIRST THE CANCER MOON SHOT.

1242
00:59:04,720 --> 00:59:07,880
SOME MAY RECALL IT WAS LAUNCHED 

1243
00:59:07,880 --> 00:59:10,520
IN 2016 BY THEN VICE PRESIDENT 

1244
00:59:10,520 --> 00:59:13,440
BIDEN WITH A GOAL OF 

1245
00:59:13,440 --> 00:59:14,080
ACCELERATING CANCER PROGRESS 

1246
00:59:14,080 --> 00:59:18,040
INTO THE TRANSLATION OF SPACE 

1247
00:59:18,040 --> 00:59:22,560
NCI'S INVESTED OVER $1 BILLION 

1248
00:59:22,560 --> 00:59:25,000
OF MOON SHOT AND SUPPORTED 

1249
00:59:25,000 --> 00:59:26,160
RESEARCH PROJECTS OVER 70 CANCER

1250
00:59:26,160 --> 00:59:33,920
SCIENCE INITIATIVES.

1251
00:59:33,920 --> 00:59:35,320
THERE'S A FEW ACCOMPLISHMENTS.

1252
00:59:35,320 --> 00:59:37,360
THE FIRST THREE YEARS OF THIS 

1253
00:59:37,360 --> 00:59:47,800
OVER 1200 PUBLICATIONS.

1254
00:59:54,160 --> 00:59:56,320
AND PRESIDENT BIDEN ANNOUNCED 

1255
00:59:56,320 --> 00:59:57,840
PLAN TO REIGNITE THE MOON SHOT 

1256
00:59:57,840 --> 01:00:08,320
TO END CANCER AS WE KNOW IT.

1257
01:00:20,280 --> 01:00:21,600
IN ORDER TO REDUCE CANCER 

1258
01:00:21,600 --> 01:00:24,520
MORTALITY THERE'S NO SINGLE WAY 

1259
01:00:24,520 --> 01:00:25,760
OF DOING THAT.

1260
01:00:25,760 --> 01:00:27,000
IT'S GOING TO REQUIRE A FOCUS ON

1261
01:00:27,000 --> 01:00:28,920
MANY THINGS ON PREVENTION AND 

1262
01:00:28,920 --> 01:00:39,440
SCREENING, TOBACCO CONTROL AS 

1263
01:00:40,400 --> 01:00:42,360
WELL AS THERAPIES THE NEXT PHASE

1264
01:00:42,360 --> 01:00:44,840
OF THE MOON SHOT IS FOCUSSING ON

1265
01:00:44,840 --> 01:00:47,000
HOW PEOPLE EXPERIENCE CANCER 

1266
01:00:47,000 --> 01:00:57,120
TODAY.

1267
01:01:27,000 --> 01:01:28,480
PREVENTION AND EARLY DETECTION 

1268
01:01:28,480 --> 01:01:32,160
AND I ENJOYED PART OF THE FIRE 

1269
01:01:32,160 --> 01:01:33,080
SIDE CHAT WITH THE DIRECTOR OF 

1270
01:01:33,080 --> 01:01:36,120
THE NATIONAL INSTITUTE ON DRUG 

1271
01:01:36,120 --> 01:01:38,160
ABUSE AND DR. BAKER, DIRECTOR OF

1272
01:01:38,160 --> 01:01:39,680
THE HEAL INITIATIVE.

1273
01:01:39,680 --> 01:01:42,560
AND DURING THIS TALK WE REALLY 

1274
01:01:42,560 --> 01:01:45,880
DISCUSSED THE LATEST PROGRESS 

1275
01:01:45,880 --> 01:01:53,640
AND CONTINUED CHALLENGES AND NIH

1276
01:01:53,640 --> 01:01:55,200
ADDRESSING THE OPIOID CRISIS.

1277
01:01:55,200 --> 01:01:57,360
A BIG PART OF THE EFFORT IS 

1278
01:01:57,360 --> 01:01:58,520
THROUGH THE HEAL INITIATIVE.

1279
01:01:58,520 --> 01:02:02,600
ONE MAJOR GOAL HAS BEEN TO 

1280
01:02:02,600 --> 01:02:04,040
DISCOVER AND VALIDATE NOVEL 

1281
01:02:04,040 --> 01:02:10,720
TARGETS FOR SAFE AND EFFECTIVE 

1282
01:02:10,720 --> 01:02:15,680
NON-ADDICTIVE PAIN MEDICINE.

1283
01:02:15,680 --> 01:02:20,640
AND THERE'S PATENTS TO TREAT 

1284
01:02:20,640 --> 01:02:22,720
CHRONIC PAIN AND MIGRAINES AND 

1285
01:02:22,720 --> 01:02:27,320
AN IND FOR FIRST IN CLASS, 

1286
01:02:27,320 --> 01:02:29,000
NON-ADDICTIVE CANDIDATE FOR 

1287
01:02:29,000 --> 01:02:29,360
TREATING PAIN.

1288
01:02:29,360 --> 01:02:30,160
OVER 50 THERAPIES ARE BEING 

1289
01:02:30,160 --> 01:02:33,600
INVOLVED.

1290
01:02:33,600 --> 01:02:40,480
23 INDs AND A STUDY OF OPIOID 

1291
01:02:40,480 --> 01:02:48,320
VACCINE IS ONGOING.

1292
01:02:48,320 --> 01:02:52,560
USING DEVICES TO TREAT PAIN IN 

1293
01:02:52,560 --> 01:03:02,200
OPIOID USE DISORDER.

1294
01:03:02,200 --> 01:03:03,960
THIS IS THE VICE PRESIDENT'S 

1295
01:03:03,960 --> 01:03:04,960
CABINET MEETING PLAN.

1296
01:03:04,960 --> 01:03:07,600
THE MATERNAL DEATH RATE IN THE 

1297
01:03:07,600 --> 01:03:12,640
U.S. HAS RISEN NEARLY 37% SINCE 

1298
01:03:12,640 --> 01:03:12,840
2018.

1299
01:03:12,840 --> 01:03:16,240
THIS CRISIS IS PARTICULARLY 

1300
01:03:16,240 --> 01:03:18,200
ACUTE AMONG BLACK WOMEN WHO ARE 

1301
01:03:18,200 --> 01:03:20,400
THREE TIMES MORE LIKELY TO DIE 

1302
01:03:20,400 --> 01:03:24,480
FROM A PREGNANCY-RELATED 

1303
01:03:24,480 --> 01:03:26,360
COMPLICATION AS WHITE WOMEN 

1304
01:03:26,360 --> 01:03:28,520
REGARDLESS OF INCOME OR 

1305
01:03:28,520 --> 01:03:28,800
EDUCATION.

1306
01:03:28,800 --> 01:03:30,400
THE ADMINISTRATION IS DEVELOPING

1307
01:03:30,400 --> 01:03:31,720
A NATIONAL STRATEGY THAT 

1308
01:03:31,720 --> 01:03:34,480
INCLUDES COMMITMENTS FROM 

1309
01:03:34,480 --> 01:03:36,080
AGENCIES ACROSS THE GOVERNMENT.

1310
01:03:36,080 --> 01:03:37,920
AT THE MEETING, DR. BIANCHI AND 

1311
01:03:37,920 --> 01:03:40,680
I WERE PRIVILEGED TO JOIN THE 

1312
01:03:40,680 --> 01:03:41,920
OVER ALL TEAM TO DISCUSS NIH'S 

1313
01:03:41,920 --> 01:03:52,040
ROLE.

1314
01:03:53,080 --> 01:03:54,440
AND INCLUDING SUPPORT AND 

1315
01:03:54,440 --> 01:03:56,080
BUILDING THE NEXT GENERATION OF 

1316
01:03:56,080 --> 01:04:00,520
MATERNAL HEALTH RESEARCHERS 

1317
01:04:00,520 --> 01:04:04,040
WHICH IS VERY IMPORTANT.

1318
01:04:04,040 --> 01:04:06,960
WE'RE WORKING TO INCREASE 

1319
01:04:06,960 --> 01:04:07,880
PARTICIPATION OF UNDER 

1320
01:04:07,880 --> 01:04:08,520
REPRESENTED RESEARCHERS IN THIS 

1321
01:04:08,520 --> 01:04:15,720
AREA.

1322
01:04:15,720 --> 01:04:18,960
THERE'S A LOCI SUPPORTING 

1323
01:04:18,960 --> 01:04:25,040
RESEARCH FOCUSSED ON REDUCING 

1324
01:04:25,040 --> 01:04:26,280
PREVENTIBLE CAUSES AND WORKING 

1325
01:04:26,280 --> 01:04:28,000
WITH THE INDIVIDUAL BEFORE, 

1326
01:04:28,000 --> 01:04:30,280
AFTER AND DURING DELIVERY AND A 

1327
01:04:30,280 --> 01:04:32,440
SPECIAL EMPHASIS ON THE HEALTH 

1328
01:04:32,440 --> 01:04:35,840
DISPARITIES BEING OBSERVED IN 

1329
01:04:35,840 --> 01:04:37,000
MATERNAL HEALTH COMMUNITY.

1330
01:04:37,000 --> 01:04:38,680
ONE EXAMPLE OF AN ACCOMPLISHMENT

1331
01:04:38,680 --> 01:04:46,160
TO DATE IS THE APPROVAL BY THE 

1332
01:04:46,160 --> 01:04:49,680
FDA TO TREAT PAIN ASSOCIATED 

1333
01:04:49,680 --> 01:04:50,800
WITH ENDOMETRIOSIS.

1334
01:04:50,800 --> 01:05:01,240
A DEVASTATING CONDITION.

1335
01:05:02,080 --> 01:05:04,960
A QUICK SNAPSHOT OF WHERE THE 

1336
01:05:04,960 --> 01:05:06,080
ALL OF US PROGRAM IS.

1337
01:05:06,080 --> 01:05:08,120
AS WE APPROACH THE MILESTONE OF 

1338
01:05:08,120 --> 01:05:11,320
NEARLY 500,000 CONSENTED 

1339
01:05:11,320 --> 01:05:14,480
PARTICIPANTS, MORE THAN 338,000 

1340
01:05:14,480 --> 01:05:17,200
HAVE COMPLETED ALL THE INITIAL 

1341
01:05:17,200 --> 01:05:18,960
STEPS TO SHARE THEIR DATA WHICH 

1342
01:05:18,960 --> 01:05:20,120
IS NOW AVAILABLE IN THE 

1343
01:05:20,120 --> 01:05:22,120
RESEARCHER WORK BENCH BEING USED

1344
01:05:22,120 --> 01:05:32,560
BY OVER 2200 RESEARCHERS.

1345
01:05:34,040 --> 01:05:34,760
ELECTRONIC HEALTH RECORDS ON LAB

1346
01:05:34,760 --> 01:05:36,520
MEASURES AND DRUG EXPOSURES.

1347
01:05:36,520 --> 01:05:39,280
SOME EXTEND BACK DECADES OR MORE

1348
01:05:39,280 --> 01:05:49,040
AS YOU CAN SEE BY THE PLOT.

1349
01:05:49,040 --> 01:05:51,440
PHYSICAL MEASURES AND FITBIT 

1350
01:05:51,440 --> 01:05:54,600
DATA ARE RELATIVELY NEW TO THE 

1351
01:05:54,600 --> 01:05:57,480
GAME BUT ROBUST IN MEMBERS WHO 

1352
01:05:57,480 --> 01:05:58,760
CONTRIBUTED THESE.

1353
01:05:58,760 --> 01:06:00,440
WE WILL LAUNCH PEDIATRIC ENROLL 

1354
01:06:00,440 --> 01:06:01,800
MANY IN THE FUTURE BUT AS A 

1355
01:06:01,800 --> 01:06:04,440
RESULT OF THE EXTENSIVE HEALTH 

1356
01:06:04,440 --> 01:06:08,480
RECORD COLLECTION, WE ALREADY 

1357
01:06:08,480 --> 01:06:12,440
HAVE DATA ON SOME PARTICIPANTS 

1358
01:06:12,440 --> 01:06:15,520
WHICH MAKES FOR INTERESTING 

1359
01:06:15,520 --> 01:06:15,880
OPPORTUNITIES.

1360
01:06:15,880 --> 01:06:17,920
THIS MARCH WE RELEASED ALMOST 

1361
01:06:17,920 --> 01:06:24,040
100 WHOLE GENOME SEQUENCES AND 

1362
01:06:24,040 --> 01:06:26,760
IF I CAN HAVE THE NEXT SLIDE 

1363
01:06:26,760 --> 01:06:28,880
THIS IS IMPORTANT FIGURE.

1364
01:06:28,880 --> 01:06:32,040
IT UNDER SCORES THAT UP UNTIL 

1365
01:06:32,040 --> 01:06:34,040
NOW, OVER 90% OF PARTICIPANTS 

1366
01:06:34,040 --> 01:06:36,680
FROM LARGE GENOMIC STUDIES HAVE 

1367
01:06:36,680 --> 01:06:42,080
BEEN OF EUROPEAN DESCENT IN THE 

1368
01:06:42,080 --> 01:06:43,000
GRAY BARS.

1369
01:06:43,000 --> 01:06:48,160
THE LACK OF DIVERSITY IN 

1370
01:06:48,160 --> 01:06:52,400
RESEARCH HAS HINDERED SCIENTIFIC

1371
01:06:52,400 --> 01:06:53,120
OPPORTUNITIES.

1372
01:06:53,120 --> 01:06:55,720
IN THE FIRST RELEASE OF NEARLY 

1373
01:06:55,720 --> 01:06:56,920
100,000 GENOME SEQUENCE, ALL OF 

1374
01:06:56,920 --> 01:07:00,400
US ARE CONTRIBUTING TO THE 

1375
01:07:00,400 --> 01:07:01,600
GLOBAL DIVERSITY OF DATA WITH 

1376
01:07:01,600 --> 01:07:04,880
80% OF PARTICIPANTS COMING FROM 

1377
01:07:04,880 --> 01:07:09,240
BACKGROUNDS UNDER REPRESENTED IN

1378
01:07:09,240 --> 01:07:13,280
BIOMEDICAL RESEARCH AND OTHER 

1379
01:07:13,280 --> 01:07:15,280
RACE AND ETHNICITY.

1380
01:07:15,280 --> 01:07:16,840
AS A RESULT WE'RE OBSERVING MORE

1381
01:07:16,840 --> 01:07:21,440
UNIQUE VARIANTS MORE THAN 593 

1382
01:07:21,440 --> 01:07:23,920
MILLION INCLUDING 193 MILLION 

1383
01:07:23,920 --> 01:07:25,840
VARIANTS WITH THREE OR MORE 

1384
01:07:25,840 --> 01:07:31,360
OCCURRENCES THAT HAVE NOT BEEN 

1385
01:07:31,360 --> 01:07:33,560
SEEN.

1386
01:07:33,560 --> 01:07:35,360
OUR PARTICIPANTS ARE LEADING THE

1387
01:07:35,360 --> 01:07:37,000
WAY TO MORE REPRESENTATION IN 

1388
01:07:37,000 --> 01:07:38,240
MEDICAL RESEARCH.

1389
01:07:38,240 --> 01:07:40,080
OVER TIME AS WE EXPAND DATA AND 

1390
01:07:40,080 --> 01:07:44,440
NEW TOOLS WE HOPE THE DATA SET 

1391
01:07:44,440 --> 01:07:47,480
IS GOING TO PROVIDE ENDLESS 

1392
01:07:47,480 --> 01:07:48,600
POSSIBILITIES FOR DISCOVERY TO 

1393
01:07:48,600 --> 01:07:49,680
UNDERSTAND THE ROLE OF GENES, 

1394
01:07:49,680 --> 01:07:51,920
VARIANTS AND OTHER FACTORS THAT 

1395
01:07:51,920 --> 01:07:52,520
COMBINE TO EFFECT HEALTH AND 

1396
01:07:52,520 --> 01:07:58,920
DISEASE.

1397
01:07:58,920 --> 01:08:01,760
DAVID IS POINTING OUT THERE'S 

1398
01:08:01,760 --> 01:08:03,160
ANOTHER ROLE RELEASED QUITE SOON

1399
01:08:03,160 --> 01:08:04,440
WHICH WILL MORE THAN DOUBLE THE 

1400
01:08:04,440 --> 01:08:07,360
NUMBER WHICH IS QUITE 

1401
01:08:07,360 --> 01:08:08,480
REMARKABLE.

1402
01:08:08,480 --> 01:08:12,400
WE'LL COME BACK TO YOUR 

1403
01:08:12,400 --> 01:08:13,000
QUESTION.

1404
01:08:13,000 --> 01:08:15,320
WHY DON'T YOU DO IT NOW.

1405
01:08:15,320 --> 01:08:16,640
THEN WE'LL GO TO GARTH'S 

1406
01:08:16,640 --> 01:08:18,440
QUESTION.

1407
01:08:18,440 --> 01:08:18,960
SHELLY, A QUESTION?

1408
01:08:18,960 --> 01:08:24,560
>> YES, THANK YOU.

1409
01:08:24,560 --> 01:08:26,040
MY QUESTION WAS DAVID ANSWERED 

1410
01:08:26,040 --> 01:08:31,880
WHAT WAS COMING UP.

1411
01:08:31,880 --> 01:08:33,920
WHAT PERCENTAGE IN WHAT WE HAVE 

1412
01:08:33,920 --> 01:08:35,560
SO FAR IS FEMALE.

1413
01:08:35,560 --> 01:08:39,600
THE DIFFERENCE IN MOUSE STUDIES 

1414
01:08:39,600 --> 01:08:41,400
IS DRAMATIC IN SOME AREAS OF THE

1415
01:08:41,400 --> 01:08:42,040
DIFFERENCE BETWEEN FEMALE AND 

1416
01:08:42,040 --> 01:08:43,680
MALE RESPONSES.

1417
01:08:43,680 --> 01:08:47,800
I WAS CURIOUS WHAT THE OBJECTIVE

1418
01:08:47,800 --> 01:08:52,480
AND CURRENT STATE IS.

1419
01:08:52,480 --> 01:09:02,840
>> THIS IS BALANCED.

1420
01:09:06,800 --> 01:09:12,480
WE CAN GET A SPECIFIC BREAK DOWN

1421
01:09:12,480 --> 01:09:12,960
FOR YOU.

1422
01:09:12,960 --> 01:09:15,480
>> CIRCLING BACK TO
GARTH'S 

1423
01:09:15,480 --> 01:09:18,600
QUESTION, IS THE MATERNAL HEALTH

1424
01:09:18,600 --> 01:09:20,400
INITIATIVE, TRANS-NIH, TARA, 

1425
01:09:20,400 --> 01:09:22,920
WOULD YOU LIKE TO COMMENT ON 

1426
01:09:22,920 --> 01:09:23,160
THAT?

1427
01:09:23,160 --> 01:09:33,040
I DON'T THINK WE HAVE DIANA YET.

1428
01:09:33,040 --> 01:09:36,640
>> THE INITIATIVE IS
IMPROVE.

1429
01:09:36,640 --> 01:09:45,800
IT IS A TRANS-NIH EFFORT AND 

1430
01:09:45,800 --> 01:09:56,120
IT'S OVER 10 AT THIS POINT.

1431
01:09:56,120 --> 01:10:00,040
>> THERE'S NATIVE AND
AMERICAN 

1432
01:10:00,040 --> 01:10:02,800
ASIAN REPRESENTATION.

1433
01:10:02,800 --> 01:10:04,680
THE PARTICIPATION OF NATIVE 

1434
01:10:04,680 --> 01:10:11,000
AMERICANS IN STUDIES OF THIS 

1435
01:10:11,000 --> 01:10:16,400
TYPE CAN RAISE ISSUES AT THE 

1436
01:10:16,400 --> 01:10:20,760
TRIBAL LEVEL.

1437
01:10:20,760 --> 01:10:27,960
WE HAVE DOWN EXTENSIVE WORK 

1438
01:10:27,960 --> 01:10:28,560
CLOSELY WITH TRIBAL LEADERS 

1439
01:10:28,560 --> 01:10:38,880
ACROSS THE COUNTRY.

1440
01:10:40,400 --> 01:10:42,520
AND ATUL IS PUTTING THE MOST 

1441
01:10:42,520 --> 01:10:43,120
RECENT PARTICIPANT DASHBOARD 

1442
01:10:43,120 --> 01:10:50,920
HERE.

1443
01:10:50,920 --> 01:10:54,520
THIS IS IN REGARD TO NATIVE AND 

1444
01:10:54,520 --> 01:10:56,200
ALASKAN NATIVES.

1445
01:10:56,200 --> 01:10:59,360
WE HAVE TO DO THIS AS GARY 

1446
01:10:59,360 --> 01:11:00,600
GIBBONS WOULD SAY LIKE AT THE 

1447
01:11:00,600 --> 01:11:03,120
SPEED OF TRUST.

1448
01:11:03,120 --> 01:11:06,160
SO WE'RE WORKING THROUGH THOSE 

1449
01:11:06,160 --> 01:11:06,400
ISSUES.

1450
01:11:06,400 --> 01:11:10,800
I KNOW -- AND GARTH HAD A 

1451
01:11:10,800 --> 01:11:11,480
QUESTION.

1452
01:11:11,480 --> 01:11:22,040
ANY OTHER IN THERE I'VE MISSED?

1453
01:11:24,600 --> 01:11:24,960
THANK YOU FOR YOUR 

1454
01:11:24,960 --> 01:11:35,240
CONTRIBUTIONS.

1455
01:11:37,960 --> 01:11:43,680
THIS RIBBON-CUTTING CEREMONY HAS

1456
01:11:43,680 --> 01:11:43,960
IMPORTANCE.

1457
01:11:43,960 --> 01:11:47,640
I WAS PLEASED TO JOIN 

1458
01:11:47,640 --> 01:11:50,320
DR. GILLMAN AND DR. SCHWETZ AND 

1459
01:11:50,320 --> 01:11:52,480
OTHERS TO INITIATIVE THE OPENING

1460
01:11:52,480 --> 01:11:54,720
OF THE NEW CLINICAL CENTER 

1461
01:11:54,720 --> 01:12:05,080
OUT-PATIENT PHARMACY.

1462
01:12:38,800 --> 01:12:42,720
WE ARE MOSTLY ELIMINATING ERRORS

1463
01:12:42,720 --> 01:12:44,640
AND SO MUCH AUTOMATION.

1464
01:12:44,640 --> 01:12:46,840
AS A RESULT WE THINK WE'LL BOOST

1465
01:12:46,840 --> 01:12:49,360
THE MORALE OF THE STAFF OF FOLKS

1466
01:12:49,360 --> 01:12:49,920
THAT WORK HERE.

1467
01:12:49,920 --> 01:12:52,200
I DON'T KNOW IF ALFRED OR TARA 

1468
01:12:52,200 --> 01:12:53,760
WOULD LIKE TO COMMENT ON THIS.

1469
01:12:53,760 --> 01:12:55,880
I KNOW YOU HAVE ALL BEEN 

1470
01:12:55,880 --> 01:13:04,400
INVOLVED WITH THIS.

1471
01:13:04,400 --> 01:13:10,320
>> IT'S IMPRESSIVE AND 

1472
01:13:10,320 --> 01:13:13,400
OPTIMISTIC TO SEE.

1473
01:13:13,400 --> 01:13:17,480
THERE'S IMPROVED SAFETY AND 

1474
01:13:17,480 --> 01:13:17,840
EFFICIENCY.

1475
01:13:17,840 --> 01:13:20,080
>> STAFF HAS BEEN WAITING
FOR A 

1476
01:13:20,080 --> 01:13:22,040
LONG TIME AND WAITING AND HAPPY 

1477
01:13:22,040 --> 01:13:26,080
TO HAVE THIS IN WHAT THEY FEEL 

1478
01:13:26,080 --> 01:13:28,920
SAY MUCH MORE PROFESSIONAL 

1479
01:13:28,920 --> 01:13:29,200
ENVIRONMENT.

1480
01:13:29,200 --> 01:13:32,960
>> THANK YOU BOTH.

1481
01:13:32,960 --> 01:13:34,320
THANKS TO THE CLINICAL CENTER 

1482
01:13:34,320 --> 01:13:36,440
STAFF AND ALL WHO MADE IT 

1483
01:13:36,440 --> 01:13:39,160
HAPPEN.

1484
01:13:39,160 --> 01:13:44,320
I HAD THE PRIVILEGE WITH 

1485
01:13:44,320 --> 01:13:48,440
DR. ELISEO PEREZ-STABLE WHEN 

1486
01:13:48,440 --> 01:13:52,280
PRESIDENT BIDEN SIGNED THE NIHMB

1487
01:13:52,280 --> 01:13:58,520
REVITALIZATION ACT OF 2021.

1488
01:13:58,520 --> 01:14:08,560
-- NIMHD.

1489
01:14:08,560 --> 01:14:09,960
AND THIS ENDOWMENT PROGRAM 

1490
01:14:09,960 --> 01:14:11,320
PROVIDES FUNDING TO THE 

1491
01:14:11,320 --> 01:14:12,600
ENDOWMENT OF ACADEMIC 

1492
01:14:12,600 --> 01:14:15,680
INSTITUTIONS WITH THE GOAL TO 

1493
01:14:15,680 --> 01:14:17,200
HELP BUILD INFRASTRUCTURE AND 

1494
01:14:17,200 --> 01:14:18,800
CAPACITY TO PROMOTE MINORITY 

1495
01:14:18,800 --> 01:14:20,000
HEALTH AND HEALTH DISPARITIES 

1496
01:14:20,000 --> 01:14:21,880
RESEARCH AND INSTITUTIONS THAT 

1497
01:14:21,880 --> 01:14:27,000
HAVE LIMITED ENDOWMENTS.

1498
01:14:27,000 --> 01:14:29,000
INITIALLY AIMS TO ENHANCE 

1499
01:14:29,000 --> 01:14:30,360
RECRUITMENT FROM POPULATIONS 

1500
01:14:30,360 --> 01:14:31,880
UNDER REPRESENTED IN BIOMEDICAL 

1501
01:14:31,880 --> 01:14:33,840
RESEARCH AND PROMOTE TRAINING IN

1502
01:14:33,840 --> 01:14:35,400
THE FIELD OF MINORITY HEALTH AND

1503
01:14:35,400 --> 01:14:36,800
HEALTH DISPARITY RESEARCH.

1504
01:14:36,800 --> 01:14:39,400
WHAT'S UNIQUE ABOUT THIS IS THIS

1505
01:14:39,400 --> 01:14:41,720
DOES NOT DIRECTLY FUND RESEARCH 

1506
01:14:41,720 --> 01:14:44,240
PROGRAMS BUT AWARDS 

1507
01:14:44,240 --> 01:14:44,920
INSTITUTIONS, RESOURCES FOR THE 

1508
01:14:44,920 --> 01:14:46,840
ENDOWMENT THAT MUST BE INVESTED 

1509
01:14:46,840 --> 01:14:49,600
AND MAINTAINED FOR AT LEAST 20 

1510
01:14:49,600 --> 01:14:51,440
YEARS AFTER THE AWARD PERIOD 

1511
01:14:51,440 --> 01:14:51,840
ENDS.

1512
01:14:51,840 --> 01:14:55,080
AND GRANTEES MUST PROVIDE A 

1513
01:14:55,080 --> 01:14:55,760
FIVE-YEAR STRATEGIC PLAN THAT 

1514
01:14:55,760 --> 01:14:57,840
ESTABLISHES THE PRIORITIES FOR 

1515
01:14:57,840 --> 01:15:00,600
THE USE AND GROWTH OF THE 

1516
01:15:00,600 --> 01:15:01,880
ENDOWMENT INCOME.

1517
01:15:01,880 --> 01:15:04,080
THE NEW ACT EXPANDS ELIGIBILITY 

1518
01:15:04,080 --> 01:15:08,960
FOR THE PROGRAM TO INCLUDE BOTH 

1519
01:15:08,960 --> 01:15:12,400
FORMER NIMHD AND HRSA CENTERS OF

1520
01:15:12,400 --> 01:15:22,600
EXCELLENCE.

1521
01:15:29,640 --> 01:15:31,120
THIS SLIDE SUMMARIZES THE BILL 

1522
01:15:31,120 --> 01:15:32,720
AND MELINDA GATES FOUNDATION 

1523
01:15:32,720 --> 01:15:42,960
COLLABORATION.

1524
01:15:43,800 --> 01:15:46,920
WE HAD THE ANNUAL HEALTH LECTURE

1525
01:15:46,920 --> 01:15:52,080
AT THAT TIME NIH AND BILL AND 

1526
01:15:52,080 --> 01:16:00,400
MELINDA GATES LAUNCHED THE 

1527
01:16:00,400 --> 01:16:02,440
NATURAL PARTNERSHIP HAVE 

1528
01:16:02,440 --> 01:16:04,520
OCCURRED REPRESENT 57% OF GLOBAL

1529
01:16:04,520 --> 01:16:08,000
HEALTH R&D AND SHARE
MULTIPLE 

1530
01:16:08,000 --> 01:16:10,520
CLINICAL AND RESEARCH 

1531
01:16:10,520 --> 01:16:10,840
PRIORITIES.

1532
01:16:10,840 --> 01:16:14,000
COVID INFECTION RATES 

1533
01:16:14,000 --> 01:16:16,320
PERMISSIBLE, WE'LL HAVE OUR 

1534
01:16:16,320 --> 01:16:18,080
ANNUAL MEETING THIS DECEMBER 

1535
01:16:18,080 --> 01:16:19,800
HOSTING MR. GATES AND THE 

1536
01:16:19,800 --> 01:16:23,800
FOUNDATION SENIOR LEADERSHIP AND

1537
01:16:23,800 --> 01:16:25,880
SCIENTIFIC STAFF.

1538
01:16:25,880 --> 01:16:28,240
THIS PARTICULAR SLIDE HIGHLIGHTS

1539
01:16:28,240 --> 01:16:30,400
SEVERAL JOINT PROJECTS WE THINK 

1540
01:16:30,400 --> 01:16:39,360
COULD BE GAME CHANGERS IN HIV.

1541
01:16:39,360 --> 01:16:44,880
NEUTRALIZING GLOBAL ANTIBODIES 

1542
01:16:44,880 --> 01:16:49,800
AND HUMAN PAPILLOMA VACCINES AND

1543
01:16:49,800 --> 01:16:51,280
IMPROVE HPV VACCINATION COVERAGE

1544
01:16:51,280 --> 01:16:56,840
BY REDUCING COST AND SIMPLIFYING

1545
01:16:56,840 --> 01:16:57,600
ADMINISTRATION.

1546
01:16:57,600 --> 01:16:59,480
A NOVEL TB VACCINE TO STOP 

1547
01:16:59,480 --> 01:17:06,680
LATENT TB FROM BECOMING ACTIVE 

1548
01:17:06,680 --> 01:17:13,440
AND THE HIV SICKLE CELL THESE 

1549
01:17:13,440 --> 01:17:15,880
AIMED AT ADVANCING LOW-COST 

1550
01:17:15,880 --> 01:17:18,640
DELIVERY SYSTEMS BASED ON GENE 

1551
01:17:18,640 --> 01:17:24,400
THERAPY CANDIDATES FOR SICKLE 

1552
01:17:24,400 --> 01:17:30,600
CELL AND HIV.

1553
01:17:30,600 --> 01:17:34,400
FINDING WAYS TO ELIMINATE THE 

1554
01:17:34,400 --> 01:17:37,600
RESERVOIRS OF HIV, HOW TO 

1555
01:17:37,600 --> 01:17:38,680
DEVELOP SAFE GENE DELIVERY 

1556
01:17:38,680 --> 01:17:41,400
SYSTEMS WITH A FOCUS ON NANO 

1557
01:17:41,400 --> 01:17:44,200
PARTICLES THAT SCALE TO WHAT IS 

1558
01:17:44,200 --> 01:17:44,440
REQUIRED.

1559
01:17:44,440 --> 01:17:48,440
THEN OF COURSE TO BETTER 

1560
01:17:48,440 --> 01:17:50,440
UNDERSTAND THE SAFETY SYSTEMS 

1561
01:17:50,440 --> 01:17:53,080
AND GENE THERAPY TRIALS TO 

1562
01:17:53,080 --> 01:17:54,600
IMPROVE WAYS OF MONITORING THESE

1563
01:17:54,600 --> 01:18:04,560
EFFORTS.

1564
01:18:04,560 --> 01:18:07,720
THIS SAY SUMMARY OF ENORMOUS 

1565
01:18:07,720 --> 01:18:13,360
EFFORT OF THE HUMAN HEREDITARY 

1566
01:18:13,360 --> 01:18:15,200
PROGRAM WHICH EXPLORE GENETIC 

1567
01:18:15,200 --> 01:18:17,280
CONTRIBUTORS TO DISEASES.

1568
01:18:17,280 --> 01:18:19,000
THIS IS SUPPORTED BY THE NIH 

1569
01:18:19,000 --> 01:18:24,720
COMMON FUND AND THE WELCOME 

1570
01:18:24,720 --> 01:18:33,360
TRUST.

1571
01:18:33,360 --> 01:18:36,600
HD AFRICA HAS FUNDED OVER 50 

1572
01:18:36,600 --> 01:18:40,320
PROJECTS IN MORE THAN 30 

1573
01:18:40,320 --> 01:18:40,560
COUNTRIES.

1574
01:18:40,560 --> 01:18:43,080
MANY ACHIEVEMENTS INCLUDING OVER

1575
01:18:43,080 --> 01:18:46,200
100,000 PARTICIPANTS.

1576
01:18:46,200 --> 01:18:52,440
50,000 SAMPLES OF GENOTYPE, 26 

1577
01:18:52,440 --> 01:18:53,680
CORE PHENOTYPES IDENTIFIED.

1578
01:18:53,680 --> 01:19:00,880
IN ADDITION TO STANDING THIS UP 

1579
01:19:00,880 --> 01:19:02,760
THE CONSORTIUM CREATED 

1580
01:19:02,760 --> 01:19:08,400
REPOSITORIES IN NIGERIA, UGANDA 

1581
01:19:08,400 --> 01:19:09,760
AND SOUTH AFRICA AND SHARE 

1582
01:19:09,760 --> 01:19:13,560
COMMON METHODOLOGIES AND HOUSE 

1583
01:19:13,560 --> 01:19:14,920
DNA SAMPLES.

1584
01:19:14,920 --> 01:19:16,800
TURNS OUT ONE OF THE MOST 

1585
01:19:16,800 --> 01:19:18,640
REQUESTED DATA SETS IS FROM 

1586
01:19:18,640 --> 01:19:26,520
ANALYSIS OF 426 PARTICIPANTS 

1587
01:19:26,520 --> 01:19:27,760
COMPRISING GROUPS INCLUDING 

1588
01:19:27,760 --> 01:19:29,280
PREVIOUSLY UNSAMPLED POPULATION.

1589
01:19:29,280 --> 01:19:32,480
A RESEARCH TEAM ON THIS PROJECT 

1590
01:19:32,480 --> 01:19:34,920
UNCOVERED MORE THAN 3 MILLION 

1591
01:19:34,920 --> 01:19:36,520
PREVIOUSLY UNKNOWN VARIANTS.

1592
01:19:36,520 --> 01:19:39,880
THIS IS DESCRIBED IN A NATURE 

1593
01:19:39,880 --> 01:19:40,080
PAPER.

1594
01:19:40,080 --> 01:19:42,160
IF SOMEBODY CAN PUT THAT IN THE 

1595
01:19:42,160 --> 01:19:42,760
CHAT BOX I'D APPRECIATE THE LINK

1596
01:19:42,760 --> 01:19:52,920
TO THAT.

1597
01:19:55,640 --> 01:19:57,640
BRIEFLY AND NIH EFFORTS TO 

1598
01:19:57,640 --> 01:19:59,240
ADDRESS HARASSMENT OF ALL TYPES 

1599
01:19:59,240 --> 01:20:09,720
INCLUDING SEXUAL HARASSMENT.

1600
01:20:11,200 --> 01:20:12,720
CONGRESS STRENGTHENED OUR 

1601
01:20:12,720 --> 01:20:13,720
ABILITY TO ADDRESS HARASSMENT.

1602
01:20:13,720 --> 01:20:16,400
IT'S BEEN OUR GOAL TO ENSURE 

1603
01:20:16,400 --> 01:20:18,440
SCIENCE CONDUCTED IN A SAFE 

1604
01:20:18,440 --> 01:20:19,680
WORKPLACE AND FOLLOWING THE 2018

1605
01:20:19,680 --> 01:20:21,880
NATIONAL ACADEMIES REPORT, WE 

1606
01:20:21,880 --> 01:20:24,400
HAVE REALLY ELEVATED OUR EFFORTS

1607
01:20:24,400 --> 01:20:27,240
TO END SEXUAL HARASSMENT IN 

1608
01:20:27,240 --> 01:20:27,840
BIOMEDICAL RESEARCH.

1609
01:20:27,840 --> 01:20:30,640
UP TO NOW WE HAVE EXPECTED BUT 

1610
01:20:30,640 --> 01:20:33,160
NOT REQUIRED INSTITUTIONS NOTIFY

1611
01:20:33,160 --> 01:20:35,440
US OF CERTAIN CIRCUMSTANCES AND 

1612
01:20:35,440 --> 01:20:37,560
WE ENCOURAGE ALL STAKEHOLDERS TO

1613
01:20:37,560 --> 01:20:39,440
REPORT THEIR CONCERNS ABOUT 

1614
01:20:39,440 --> 01:20:42,120
HARASSMENT AT NIH THROUGH THE 

1615
01:20:42,120 --> 01:20:44,040
OFFICE OF EXTRAMURAL RESEARCH.

1616
01:20:44,040 --> 01:20:47,320
THANKS TO CONGRESS AND I MUST 

1617
01:20:47,320 --> 01:20:48,800
SAY THIS WAS TIRELESS EFFORT ON 

1618
01:20:48,800 --> 01:20:54,000
THEIR PART WITH THE PASSING OF 

1619
01:20:54,000 --> 01:20:55,840
SECTION 239 OF THE '22 OMNIBUS, 

1620
01:20:55,840 --> 01:21:04,520
WE NOW HAVE A NEW TOOL WHERE 

1621
01:21:04,520 --> 01:21:05,640
SOMEBODY NAMED AS A KEY 

1622
01:21:05,640 --> 01:21:08,680
PERSONNEL ON A GRANT IS REMOVED 

1623
01:21:08,680 --> 01:21:11,680
FROM THEIR POSITION OR OTHERWISE

1624
01:21:11,680 --> 01:21:12,600
DISCIPLINED FOR HARASSMENT, 

1625
01:21:12,600 --> 01:21:18,120
BULLYING OR RETALIATION OR 

1626
01:21:18,120 --> 01:21:22,960
HOSTILE WORK CONDITIONS AND IT 

1627
01:21:22,960 --> 01:21:26,400
GOES INTO EFFECT IN JULY AND 

1628
01:21:26,400 --> 01:21:31,600
WE'RE GRATEFUL TO CONGRESS FOR 

1629
01:21:31,600 --> 01:21:38,240
PROVIDING THIS.

1630
01:21:38,240 --> 01:21:41,040
MIKE, ARE YOU ON THE CALL?

1631
01:21:41,040 --> 01:21:41,920
>> YES, I AM.

1632
01:21:41,920 --> 01:21:44,080
>> WALK US THROUGH THE
DATA.

1633
01:21:44,080 --> 01:21:44,680
IT'S YOUR DATA.

1634
01:21:44,680 --> 01:21:47,280
>> THIS IS DATA ON THE 

1635
01:21:47,280 --> 01:21:48,440
HARASSMENT AND HOSTILE WORK 

1636
01:21:48,440 --> 01:21:49,920
ENVIRONMENT COMPLAINTS WE HAVE 

1637
01:21:49,920 --> 01:21:52,680
RECEIVED SINCE WE STARTED DOING 

1638
01:21:52,680 --> 01:21:54,600
THIS AT A HIGHER LEVEL BACK IN 

1639
01:21:54,600 --> 01:21:59,960
2018.

1640
01:21:59,960 --> 01:22:02,600
WE'RE SHOWING THE NUMBER OF 

1641
01:22:02,600 --> 01:22:04,400
COMPLAINTS WE RECEIVED IN EACH 

1642
01:22:04,400 --> 01:22:04,720
YEAR.

1643
01:22:04,720 --> 01:22:07,800
THESE ARE CALENDAR YEAR DATA AND

1644
01:22:07,800 --> 01:22:08,960
THE DATA ARE THROUGH I BELIEVE 

1645
01:22:08,960 --> 01:22:12,480
THE END OF APRIL, BEGINNING OF 

1646
01:22:12,480 --> 01:22:12,640
MAY.

1647
01:22:12,640 --> 01:22:17,600
SO WE'RE AT PACE NOW TO GET AT 

1648
01:22:17,600 --> 01:22:20,440
LEAST AS MANY COMPLAINTS THIS 

1649
01:22:20,440 --> 01:22:21,560
YEAR ASKED IN YEARS PAST.

1650
01:22:21,560 --> 01:22:24,400
YOU CAN SEE IN 2021, WE RECEIVED

1651
01:22:24,400 --> 01:22:26,120
160 COMPLAINTS.

1652
01:22:26,120 --> 01:22:30,120
WE'RE UP TO OVER 480 BY NOW.

1653
01:22:30,120 --> 01:22:31,560
ONE THING THAT'S INTERESTING IS 

1654
01:22:31,560 --> 01:22:35,600
THE PROPORTION OF CASES THAT ARE

1655
01:22:35,600 --> 01:22:38,440
SEXUAL HARASSMENT OPPOSED TO 

1656
01:22:38,440 --> 01:22:40,280
OTHER TYPES OF ISSUES.

1657
01:22:40,280 --> 01:22:43,640
SO YOU CAN SEE THAT BACK IN 

1658
01:22:43,640 --> 01:22:46,480
2018, 2019, MOST CASES WERE 

1659
01:22:46,480 --> 01:22:48,480
SEXUAL HARASSMENT OR SEXUAL 

1660
01:22:48,480 --> 01:22:49,440
HARASSMENT ONLY.

1661
01:22:49,440 --> 01:22:50,640
NOW WHAT HAS HAPPENED IS THE 

1662
01:22:50,640 --> 01:22:53,320
MAJORITY OF OUR CASES ARE NOT 

1663
01:22:53,320 --> 01:22:56,120
SEXUAL HARASSMENT, THEY'RE 

1664
01:22:56,120 --> 01:22:57,880
NON-SEXUAL HARASSMENT, BULLYING 

1665
01:22:57,880 --> 01:22:59,960
OR DISCRIMINATION OR OTHER FORMS

1666
01:22:59,960 --> 01:23:10,440
OF HOSTILE WORK CONDITIONS.

1667
01:23:12,040 --> 01:23:14,960
THESE ARE OUTCOMES FOR SEXUAL 

1668
01:23:14,960 --> 01:23:16,800
HARASSMENT AND HAVE OTHER DATA 

1669
01:23:16,800 --> 01:23:18,640
ON THE OUTCOMES FOR HARASSMENT 

1670
01:23:18,640 --> 01:23:21,280
OR FOR NON-SEXUAL HARASSMENT.

1671
01:23:21,280 --> 01:23:24,120
WHAT THIS SHOWS YOU IS THAT THE 

1672
01:23:24,120 --> 01:23:26,440
TOTAL NUMBER -- THE VAST 

1673
01:23:26,440 --> 01:23:29,680
MAJORITY OF CASES WE CONTACT 

1674
01:23:29,680 --> 01:23:31,120
INSTITUTIONS AND THERE'S 

1675
01:23:31,120 --> 01:23:34,120
TYPICALLY SOME KIND OF FORMAL 

1676
01:23:34,120 --> 01:23:36,400
INVESTIGATION WHICH IS 

1677
01:23:36,400 --> 01:23:37,760
UNDERTAKEN BY THE INSTITUTION.

1678
01:23:37,760 --> 01:23:40,120
ABOUT ONE-QUARTER TO ONE-THIRD 

1679
01:23:40,120 --> 01:23:44,280
OF THE TIMES THE ALLEGATIONS ARE

1680
01:23:44,280 --> 01:23:44,600
SUBSTANTIATED.

1681
01:23:44,600 --> 01:23:47,120
THIS MAYBE A BIT OF AN UNDER 

1682
01:23:47,120 --> 01:23:50,000
ESTIMATE BECAUSE IN SOME CASES A

1683
01:23:50,000 --> 01:23:51,200
SCIENTIST MAY LEAVE AN 

1684
01:23:51,200 --> 01:23:56,440
INSTITUTION OR OTHERWISE RESIGN 

1685
01:23:56,440 --> 01:23:58,920
AND THEN THE INVESTIGATION 

1686
01:23:58,920 --> 01:24:00,400
DOESN'T CONTINUE SO NO FORMAL 

1687
01:24:00,400 --> 01:24:02,080
FINDINGS MAY BE MADE.

1688
01:24:02,080 --> 01:24:04,120
WE HAD A SUBSTANTIAL NUMBER OF 

1689
01:24:04,120 --> 01:24:05,520
CASES WHERE PRINCIPLE 

1690
01:24:05,520 --> 01:24:06,440
INVESTIGATORS HAVE BEEN REMOVED 

1691
01:24:06,440 --> 01:24:09,960
OR OTHER GRANT ACCESS TAKEN LIKE

1692
01:24:09,960 --> 01:24:10,480
ADDITIONAL MONITORING.

1693
01:24:10,480 --> 01:24:12,000
WE'VE HAD A NUMBER OF CASES 

1694
01:24:12,000 --> 01:24:18,200
WHERE INVESTIGATORS HAVE LEFT 

1695
01:24:18,200 --> 01:24:20,200
THE INSTITUTION IN THE MIDDLE OR

1696
01:24:20,200 --> 01:24:22,200
A RESULT OF AN INVESTIGATION AND

1697
01:24:22,200 --> 01:24:23,760
REMOVED PEOPLE FROM PEER-REVIEW 

1698
01:24:23,760 --> 01:24:24,760
WHICH WE HAVE THE DISCRETION TO 

1699
01:24:24,760 --> 01:24:27,840
DO.

1700
01:24:27,840 --> 01:24:32,840
THAT'S IT.

1701
01:24:32,840 --> 01:24:38,320
>> GREAT.

1702
01:24:38,320 --> 01:24:41,760
THERE'S QUESTIONS IN THE CHAT 

1703
01:24:41,760 --> 01:24:41,920
BOX.

1704
01:24:41,920 --> 01:24:43,920
GARTH IS ASKING IF YOU HAVE 

1705
01:24:43,920 --> 01:24:45,360
BREAK DOWNS BY DEMOGRAPHICS?

1706
01:24:45,360 --> 01:24:46,080
>> WE DO.

1707
01:24:46,080 --> 01:24:49,040
OFF THE TOP OF MY HEAD, WHAT I 

1708
01:24:49,040 --> 01:24:54,600
DO REMEMBER IS THE VAST MAJORITY

1709
01:24:54,600 --> 01:24:56,440
INVOLVE MEN AND INVOLVE 

1710
01:24:56,440 --> 01:24:58,000
EXPERIENCED INVESTIGATORS.

1711
01:24:58,000 --> 01:25:03,240
FOR THE NON-SEXUAL HARASSMENT 

1712
01:25:03,240 --> 01:25:08,080
THEY'RE BOTH SUBSTANTIAL NUMBERS

1713
01:25:08,080 --> 01:25:14,880
OF MEN AND WOMEN WE'RE LINKING 

1714
01:25:14,880 --> 01:25:17,480
WITH ADMINISTRATIVE DATA TO GET 

1715
01:25:17,480 --> 01:25:20,240
A BETTER SENSE OF WHAT THIS 

1716
01:25:20,240 --> 01:25:20,680
LOOKS LIKE.

1717
01:25:20,680 --> 01:25:28,560
>> WHAT MIKE JUST REPORTED
IS 

1718
01:25:28,560 --> 01:25:37,240
EXTRAMURAL EFFORTS.

1719
01:25:37,240 --> 01:25:40,760
WE HAVE EXTRA DATA SO ARE YOU 

1720
01:25:40,760 --> 01:25:44,640
INTERESTED IN THE NIH WORKFORCE?

1721
01:25:44,640 --> 01:25:47,240
>> YOU ANSWERED MY
QUESTION.

1722
01:25:47,240 --> 01:25:49,120
THIS IS EXTRAMURAL.

1723
01:25:49,120 --> 01:25:51,160
BASICALLY THE QUESTION IS WHAT'S

1724
01:25:51,160 --> 01:25:54,080
THE PERCENT OF THE TOTAL 

1725
01:25:54,080 --> 01:25:58,760
POPULATION THAT IS UNDER STUDY 

1726
01:25:58,760 --> 01:26:01,640
THAT EXHIBITS THIS BEHAVIOR?

1727
01:26:01,640 --> 01:26:09,640
IS IT 1%, 20%?

1728
01:26:09,640 --> 01:26:10,480
IT'S IMPORTANT TO KEEP IN 

1729
01:26:10,480 --> 01:26:13,520
PERSPECTIVE.

1730
01:26:13,520 --> 01:26:18,960
>> THE NUMBERS THAT MIKE
SHARED 

1731
01:26:18,960 --> 01:26:24,200
WITH YOU AND KEY PERSONNEL IS A 

1732
01:26:24,200 --> 01:26:30,640
TINY FRACTION AND NO FRACTION IS

1733
01:26:30,640 --> 01:26:33,440
APPROPRIATE YOU HAVE TO KEEP IT 

1734
01:26:33,440 --> 01:26:34,560
IN PERSPECTIVE.

1735
01:26:34,560 --> 01:26:36,800
HOWARD IS ASKING, ONCE WE'RE 

1736
01:26:36,800 --> 01:26:38,800
INFORMED ARE THERE UNIFORM 

1737
01:26:38,800 --> 01:26:39,960
PROCEDURES FOR FOLLOW-UP OR 

1738
01:26:39,960 --> 01:26:40,200
ACTION?

1739
01:26:40,200 --> 01:26:43,080
>> THE ANSWER TO THAT IS
YES.

1740
01:26:43,080 --> 01:26:47,400
I WILL PUT INTO THE CHAT A PAGE 

1741
01:26:47,400 --> 01:26:50,320
WEB PAGE WHERE WE DESCRIBE OUR 

1742
01:26:50,320 --> 01:26:52,040
SOPs IN DETAIL.

1743
01:26:52,040 --> 01:26:54,120
>> WHAT HAPPENS TO A P.I.
ONCE 

1744
01:26:54,120 --> 01:26:58,440
THEY LEAVE, IT'S VERY DEPENDENT 

1745
01:26:58,440 --> 01:27:00,400
UPON INSTITUTIONAL APPROACH.

1746
01:27:00,400 --> 01:27:01,520
>> I UNDERSTAND.

1747
01:27:01,520 --> 01:27:03,520
I GUESS MY QUESTION WAS SIMILAR 

1748
01:27:03,520 --> 01:27:07,200
TO HOWARD'S IN A SENSE IF IT'S A

1749
01:27:07,200 --> 01:27:12,800
GRANT, WHAT I'M TAKING AWAY IS 

1750
01:27:12,800 --> 01:27:13,520
WHAT HAPPENS TO THE GRANTS.

1751
01:27:13,520 --> 01:27:16,080
I WONDERED IF THERE'S FOLLOW-UP 

1752
01:27:16,080 --> 01:27:20,480
IF SOMEONE WERE TO LEAVE TO 

1753
01:27:20,480 --> 01:27:24,120
FOLLOW-UP TO MAKE SURE THAT 

1754
01:27:24,120 --> 01:27:27,520
THERE'S SOME SORT OF SCRUTINY 

1755
01:27:27,520 --> 01:27:28,160
ABOUT GRANTS.

1756
01:27:28,160 --> 01:27:32,080
>> SO AGAIN, TYPICALLY WE
TRY 

1757
01:27:32,080 --> 01:27:33,920
AND KEEP THE GRANTS AND TRANSFER

1758
01:27:33,920 --> 01:27:37,560
TO ANOTHER QUALIFIED P.I.

1759
01:27:37,560 --> 01:27:39,720
OTHERWISE YOU COULD BE 

1760
01:27:39,720 --> 01:27:40,960
ENDANGERING THE CAREERS OF 

1761
01:27:40,960 --> 01:27:41,560
PEOPLE WITHIN THE LABORATORY 

1762
01:27:41,560 --> 01:27:51,400
ENVIRONMENT.

1763
01:27:51,400 --> 01:27:55,000
THESE ARE CASE BY CASE.

1764
01:27:55,000 --> 01:27:59,080
>> MAYBE -- 

1765
01:27:59,080 --> 01:28:01,840
>> NIH DOES NOT HAVE THE
ABILITY

1766
01:28:01,840 --> 01:28:04,320
TO DEBAR OR SUSPEND A SCIENTIST 

1767
01:28:04,320 --> 01:28:07,280
BUT WE HAVE A BUILT TO REFER FOR

1768
01:28:07,280 --> 01:28:08,560
DEPARTMENT AND SUSPENSION.

1769
01:28:08,560 --> 01:28:10,360
WE HAVE MADE SOME REFERRALS 

1770
01:28:10,360 --> 01:28:16,040
BECAUSE OF HARASSMENT MATTERS.

1771
01:28:16,040 --> 01:28:16,840
>> GREAT.

1772
01:28:16,840 --> 01:28:17,400
THANK YOU.

1773
01:28:17,400 --> 01:28:19,120
I'M BEING REMINDED BY TARA I'M 

1774
01:28:19,120 --> 01:28:24,480
GOING OVER TIME.

1775
01:28:24,480 --> 01:28:28,720
LET'S LET ATUL'S QUESTION BEING 

1776
01:28:28,720 --> 01:28:32,200
THE LAST ON THE TOPIC AND HAVE 

1777
01:28:32,200 --> 01:28:33,200
THINGS FOR CONSIDERATION.

1778
01:28:33,200 --> 01:28:36,840
>> WE'VE HAD A SMALL
NUMBER OF 

1779
01:28:36,840 --> 01:28:42,680
CASES WHERE IT'S A GRADUATE 

1780
01:28:42,680 --> 01:28:44,400
STUDENT HARASSING SOMEBODY ELSE 

1781
01:28:44,400 --> 01:28:45,520
OR A TECHNICIAN HARASSING 

1782
01:28:45,520 --> 01:28:51,160
SOMEBODY ELSE AND THE PROBLEM IS

1783
01:28:51,160 --> 01:28:54,600
THE P.I. OR UNIVERSITY IS NOT 

1784
01:28:54,600 --> 01:28:56,440
HANDLING IT PROPERLY.

1785
01:28:56,440 --> 01:29:00,000
WE HANDLE THOSE CASE AS 

1786
01:29:00,000 --> 01:29:02,280
ACCORDING TO OUR SOP BECAUSE AN 

1787
01:29:02,280 --> 01:29:07,560
UNSAFE ENVIRONMENT IS AN UNSAFE 

1788
01:29:07,560 --> 01:29:10,200
ENVIRONMENT EVEN FROM IF THE 

1789
01:29:10,200 --> 01:29:12,880
APPROXIMATE CAUSE ISN'T THE KEY 

1790
01:29:12,880 --> 01:29:13,160
PERSONNEL.

1791
01:29:13,160 --> 01:29:21,200
THOSE ARE CASES WE DEAL WITH.

1792
01:29:21,200 --> 01:29:23,800
>> SO THIS IS GOING TO BE 

1793
01:29:23,800 --> 01:29:24,640
UNCOMFORTABLE TO MANY OF YOU BUT

1794
01:29:24,640 --> 01:29:27,360
ONE THING THAT KEEPS ME UP AT 

1795
01:29:27,360 --> 01:29:31,880
NIGHT IS INCREASINGLY NIH 

1796
01:29:31,880 --> 01:29:34,280
RESOURCES ARE BEING CONCENTRATED

1797
01:29:34,280 --> 01:29:36,640
IN FEWER AND FEWER INSTITUTIONS 

1798
01:29:36,640 --> 01:29:39,800
AND THE TOP 20 MAY BECOME THE 

1799
01:29:39,800 --> 01:29:41,720
ONLY 20 IF WE'RE NOT CAREFUL.

1800
01:29:41,720 --> 01:29:44,680
I SHOULD STATE UP FRONT MY 

1801
01:29:44,680 --> 01:29:44,920
BIASES.

1802
01:29:44,920 --> 01:29:46,360
SOME OF YOU KNOW I'M A GRADUATE 

1803
01:29:46,360 --> 01:29:50,600
OF THE CITY COLLEGE OF NEW YORK.

1804
01:29:50,600 --> 01:29:52,600
I HAVE QUIPPED ON MORE THAN ONE 

1805
01:29:52,600 --> 01:29:55,000
OCCASION WHEN I MOVED FROM A 

1806
01:29:55,000 --> 01:29:57,640
SCHOOL IN BUFFALO NEW YORK TO A 

1807
01:29:57,640 --> 01:29:59,480
MEDICAL SCHOOL IN NEW YORK I 

1808
01:29:59,480 --> 01:30:04,200
WENT FROM OKAY TO BEING A GENIUS

1809
01:30:04,200 --> 01:30:08,640
AND I THINK THIS CONCENTRATION 

1810
01:30:08,640 --> 01:30:11,960
OF RESOURCES IS REALLY SOMETHING

1811
01:30:11,960 --> 01:30:21,280
THAT I WORRY A GREAT DEAL ABOUT.

1812
01:30:21,280 --> 01:30:23,200
I KNOW I DID POOR TIME 

1813
01:30:23,200 --> 01:30:24,800
MANAGEMENT HERE AND HOPEFULLY 

1814
01:30:24,800 --> 01:30:26,160
WE'LL HAVE SPARE TIME LATER AND 

1815
01:30:26,160 --> 01:30:27,200
IN THE MEETING TO COME BACK TO 

1816
01:30:27,200 --> 01:30:29,480
IT, BUT THAT'S THE FIRST THING I

1817
01:30:29,480 --> 01:30:31,240
WANTED TO RAISE TO THE COUNCIL 

1818
01:30:31,240 --> 01:30:41,600
AS SOMETHING I WORRY ABOUT.

1819
01:30:41,600 --> 01:30:44,920
THE OTHER THING I WORRY ABOUT IS

1820
01:30:44,920 --> 01:30:45,800
MISINFORMATION IN AND AROUND 

1821
01:30:45,800 --> 01:30:46,120
SCIENCE.

1822
01:30:46,120 --> 01:30:48,480
THE FACT THAT THERE'S A LACK OF 

1823
01:30:48,480 --> 01:30:51,360
TRUST IN SCIENCE BY SO MANY 

1824
01:30:51,360 --> 01:30:54,280
PEOPLE TODAY -- AND THIS IS NOT 

1825
01:30:54,280 --> 01:30:59,240
A NEW PHENOMENON BUT SEEMS TO BE

1826
01:30:59,240 --> 01:31:00,600
SPREADING IN A VERY MALIGNANT 

1827
01:31:00,600 --> 01:31:04,400
SORT OF WAY.

1828
01:31:04,400 --> 01:31:05,240
THIS TOO BOTHERS ME A GREAT 

1829
01:31:05,240 --> 01:31:10,120
DEAL.

1830
01:31:10,120 --> 01:31:13,000
I DON'T WANT TO MAKE TOO MUCH OF

1831
01:31:13,000 --> 01:31:17,320
A CONNECTION BETWEEN THESE TWO 

1832
01:31:17,320 --> 01:31:17,840
OBSERVATIONS BUT IF YOU 

1833
01:31:17,840 --> 01:31:20,320
CONCENTRATE MUCH OF THE 

1834
01:31:20,320 --> 01:31:24,400
SCIENTIFIC EFFORT IN A VERY 

1835
01:31:24,400 --> 01:31:26,960
SMALL NUMBER OF INSTITUTIONS, 

1836
01:31:26,960 --> 01:31:28,360
THE OPPORTUNITY FOR LOCAL 

1837
01:31:28,360 --> 01:31:31,240
COMMUNITIES TO EMBRACE AND 

1838
01:31:31,240 --> 01:31:36,480
ENGAGE WITH WORKING SCIENTISTS 

1839
01:31:36,480 --> 01:31:41,360
IS LESSENED.

1840
01:31:41,360 --> 01:31:43,400
I DON'T MEAN TO IMPLY IT'S 

1841
01:31:43,400 --> 01:31:45,240
CAUSAL BUT EVEN IF THERE'S NO 

1842
01:31:45,240 --> 01:31:47,400
LINK AT ALL, THESE ARE TWO 

1843
01:31:47,400 --> 01:31:48,360
IMPORTANT ISSUES.

1844
01:31:48,360 --> 01:31:53,560
I DO WORRY ABOUT THEM.

1845
01:31:53,560 --> 01:31:54,000
OKAY.

1846
01:31:54,000 --> 01:31:54,920
I AM SENSITIVE TO THE TIME.

1847
01:31:54,920 --> 01:31:57,120
I DON'T KNOW IF ANYONE WANTS TO 

1848
01:31:57,120 --> 01:31:58,440
MAKE A QUICK COMMENT OR TWO OR 

1849
01:31:58,440 --> 01:32:01,360
IF YOU'RE ALL IN THE NEED OF A 

1850
01:32:01,360 --> 01:32:02,480
BIO BREAK, WHICH SUPPOSED TO 

1851
01:32:02,480 --> 01:32:04,000
HAVE STARTED TWO MINUTES AGO, I 

1852
01:32:04,000 --> 01:32:14,440
APOLOGIZE FOR BEING OVER.

1853
01:32:17,720 --> 01:32:18,880
ANY COMMENTS OR QUESTION?

1854
01:32:18,880 --> 01:32:22,320
>> I AGREE WITH YOU THE
TWO 

1855
01:32:22,320 --> 01:32:23,320
ISSUES ARE CRITICAL AND 

1856
01:32:23,320 --> 01:32:24,320
POTENTIALLY LINKED.

1857
01:32:24,320 --> 01:32:26,120
>> ANY OTHER QUICK
COMMENTS 

1858
01:32:26,120 --> 01:32:27,640
BEFORE WE BREAK?

1859
01:32:27,640 --> 01:32:32,480
>> THE THINGS KEEPING YOU
UP AT 

1860
01:32:32,480 --> 01:32:35,080
NIGHT I THINK ARE KEEPING US ALL

1861
01:32:35,080 --> 01:32:36,320
UP AT NIGHT.

1862
01:32:36,320 --> 01:32:41,800
WE CAN ALL WORRY TOGETHER.

1863
01:32:41,800 --> 01:32:46,000
>> DO YOU HAVE IDEAS HOW
NIH MAY

1864
01:32:46,000 --> 01:32:49,920
MOVE FORWARD TO COMBAT THESE 

1865
01:32:49,920 --> 01:32:50,160
TRENDS.

1866
01:32:50,160 --> 01:32:54,760
>> WE HAVE MANY IDEAS.

1867
01:32:54,760 --> 01:32:59,520
I THINK IT WOULD WARRANT A 

1868
01:32:59,520 --> 01:33:00,720
SEPARATE SESSION OF THE COUNCIL 

1869
01:33:00,720 --> 01:33:03,560
TO FLUSH THESE OUT.

1870
01:33:03,560 --> 01:33:05,160
MANY GROUPS ARE NOW LOOKING AT 

1871
01:33:05,160 --> 01:33:08,640
THE ISSUE OF LACK OF TRUST IN 

1872
01:33:08,640 --> 01:33:09,320
SCIENCE.

1873
01:33:09,320 --> 01:33:11,880
THAT'S SORT OF A MORE GLOBAL 

1874
01:33:11,880 --> 01:33:14,640
ISSUE, IF YOU WILL.

1875
01:33:14,640 --> 01:33:19,240
THE CONCENTRATION OF RESOURCES 

1876
01:33:19,240 --> 01:33:21,960
IN MY OPINION FAR TOO FEW 

1877
01:33:21,960 --> 01:33:23,240
SCHOOLS OR INSTITUTIONS IN 

1878
01:33:23,240 --> 01:33:27,120
GENERAL IS SOMETHING NIH HAS TO 

1879
01:33:27,120 --> 01:33:27,360
ADDRESS.

1880
01:33:27,360 --> 01:33:30,680
WE HAVE TO DO IT IN CONCERT WITH

1881
01:33:30,680 --> 01:33:31,160
THE BIOMEDICAL RESEARCH 

1882
01:33:31,160 --> 01:33:34,200
COMMUNITY.

1883
01:33:34,200 --> 01:33:36,400
>> IT SEEMS IT HAS TO BE
DONE 

1884
01:33:36,400 --> 01:33:38,040
SOON BECAUSE ANY POLICIES YOU 

1885
01:33:38,040 --> 01:33:42,320
PUT IN PLACE ARE GOING TO TAKE 

1886
01:33:42,320 --> 01:33:44,000
YEARS TO MAKE AN AFFECT.

1887
01:33:44,000 --> 01:33:54,240
>> NO QUESTION.

1888
01:33:58,040 --> 01:33:59,600
IN TERMS OF DISTRIBUTION OF 

1889
01:33:59,600 --> 01:34:00,480
FUNDING ONCE A RESEARCH TEAM, 

1890
01:34:00,480 --> 01:34:06,240
ALWAYS A RESEARCH TEAM.

1891
01:34:06,240 --> 01:34:08,040
I FULLY UNDERSTAND DIFFERENT 

1892
01:34:08,040 --> 01:34:09,280
INSTITUTIONS HAVE DIFFERENT 

1893
01:34:09,280 --> 01:34:10,160
BUSINESS MODELS AND I GET THAT 

1894
01:34:10,160 --> 01:34:17,360
COMPLETELY.

1895
01:34:17,360 --> 01:34:19,600
BY NOT PROVIDING A MORE UNIFORM 

1896
01:34:19,600 --> 01:34:19,800
FUNDING.

1897
01:34:19,800 --> 01:34:28,720
I'M TALKING ABOUT FUNDING 

1898
01:34:28,720 --> 01:34:36,400
OUTSTANDING WORK I'M TALKING 

1899
01:34:36,400 --> 01:34:38,280
ABOUT FUNDING WORK AND THERE'S 

1900
01:34:38,280 --> 01:34:39,360
MANY INSTANCES.

1901
01:34:39,360 --> 01:34:41,760
THERE'S A TENDENCY TO 

1902
01:34:41,760 --> 01:34:46,640
CONCENTRATION MORE AND MORE 

1903
01:34:46,640 --> 01:34:48,320
RESOURCES AND THERE'S RELATIVELY

1904
01:34:48,320 --> 01:34:48,720
FEW INSTITUTIONS.

1905
01:34:48,720 --> 01:34:58,840
DANA.

1906
01:34:59,440 --> 01:35:02,560
>> YOUR STATISTICS SHOW 

1907
01:35:02,560 --> 01:35:04,480
RESOURCES AND GRANTS ARE 

1908
01:35:04,480 --> 01:35:08,880
CONCENTRATED IN CERTAIN 

1909
01:35:08,880 --> 01:35:09,200
INSTITUTIONS.

1910
01:35:09,200 --> 01:35:10,960
ALSO DO YOU HAVE INFORMATION AND

1911
01:35:10,960 --> 01:35:12,640
STATISTICS ABOUT THE SAME PEOPLE

1912
01:35:12,640 --> 01:35:13,640
BE FUNDED FROM THOSE 

1913
01:35:13,640 --> 01:35:16,160
INSTITUTIONS REPEATEDLY AND 

1914
01:35:16,160 --> 01:35:17,960
TENDENCIES BETWEEN WHO GETS 

1915
01:35:17,960 --> 01:35:27,680
FUNDED AND WHAT ARE THE ISSUES.

1916
01:35:27,680 --> 01:35:29,160
>> JUST BRIEFLY AND I'LL
LET YOU

1917
01:35:29,160 --> 01:35:31,640
GO BECAUSE YOU DESERVE A BIO 

1918
01:35:31,640 --> 01:35:32,240
BREAK.

1919
01:35:32,240 --> 01:35:36,440
MANY CASES IT'S THE SAME BEING 

1920
01:35:36,440 --> 01:35:40,400
FUNDED MULTIPLE AWARDS.

1921
01:35:40,400 --> 01:35:41,840
YOU ALSO SEE THE FIRST 

1922
01:35:41,840 --> 01:35:47,120
GENERATION COMING FROM THAT 

1923
01:35:47,120 --> 01:35:49,960
INDIVIDUAL'S RESEARCH PROGRAM 

1924
01:35:49,960 --> 01:35:53,080
BUT THE SENIOR MOST PERSON 

1925
01:35:53,080 --> 01:35:58,320
REMAINS ATTACHED TO THE FUNDING 

1926
01:35:58,320 --> 01:36:00,800
GIVEN TO THE MOST JUNIOR PERSON 

1927
01:36:00,800 --> 01:36:03,280
AND THERE'S LEGITIMATE REASONS 

1928
01:36:03,280 --> 01:36:06,080
FOR THAT BUT ALSO MAKES ONE 

1929
01:36:06,080 --> 01:36:11,920
WONDER IF THIS IS SOMEBODY BUILD

1930
01:36:11,920 --> 01:36:13,520
LARGER AND LARGER RESEARCH 

1931
01:36:13,520 --> 01:36:16,040
PROGRAM THROUGH SURROGATES.

1932
01:36:16,040 --> 01:36:18,200
MIKE, LET ME LET YOU HAVE THE 

1933
01:36:18,200 --> 01:36:18,720
LAST WORD ON THIS.

1934
01:36:18,720 --> 01:36:26,560
>> GREAT QUESTION.

1935
01:36:26,560 --> 01:36:27,760
WE PUBLISHED A PAPER WE'LL PUT 

1936
01:36:27,760 --> 01:36:31,600
IN THE CHAT.

1937
01:36:31,600 --> 01:36:34,840
>> IF THE COUNCIL THINKS
THIS IS

1938
01:36:34,840 --> 01:36:36,280
SOMETHING WE SHOULD LOOK AT AND 

1939
01:36:36,280 --> 01:36:40,760
BOTH THINGS IN MORE DETAIL LET 

1940
01:36:40,760 --> 01:36:42,440
US KNOW AND WE CAN QUEUE THAT UP

1941
01:36:42,440 --> 01:36:50,120
FOR THE DECEMBER MEETING.

1942
01:36:50,120 --> 01:36:52,120
>> THAT WILL BE HELPFUL
AND I 

1943
01:36:52,120 --> 01:36:54,320
COME FROM A BIG INSTITUTION.

1944
01:36:54,320 --> 01:36:57,000
I FEEL MANY PEOPLE WHO DO NOT 

1945
01:36:57,000 --> 01:36:58,920
HAVE A HISTORY OF GETTING GRANTS

1946
01:36:58,920 --> 01:37:03,200
FROM NIH DON'T EVEN KNOW HOW TO 

1947
01:37:03,200 --> 01:37:04,200
GET INTO THE SYSTEM.

1948
01:37:04,200 --> 01:37:09,440
JUST LOOKING AT WHAT ARE THE 

1949
01:37:09,440 --> 01:37:11,120
FACTORS THAT LOOK AT STATISTICS 

1950
01:37:11,120 --> 01:37:12,680
OF THE INSTITUTIONS AND TRYING 

1951
01:37:12,680 --> 01:37:15,400
TO REMEDY THOSE FACTORS.

1952
01:37:15,400 --> 01:37:17,920
>> I THINK IT'S VERY
COMPLEX.

1953
01:37:17,920 --> 01:37:20,400
NO SINGLE SENTENCE COULD CAPTURE

1954
01:37:20,400 --> 01:37:30,680
THE COMPLEXITY.

1955
01:37:33,840 --> 01:37:37,200
I THINK OFTEN THERE'S AN OVER 

1956
01:37:37,200 --> 01:37:40,840
EMPHASIS ON QUOTE THE RESEARCH 

1957
01:37:40,840 --> 01:37:42,760
ENVIRONMENT AS IF THE ONLY PLACE

1958
01:37:42,760 --> 01:37:44,720
A CENTRIFUGE WOULD WORK IS AT 

1959
01:37:44,720 --> 01:37:55,160
SOME FAMOUS ORGANIZATION.

1960
01:37:58,680 --> 01:38:00,040
MIKE, ANY FINAL COMMENT?

1961
01:38:00,040 --> 01:38:03,720
>> NO.

1962
01:38:03,720 --> 01:38:10,200
>> SO WITH THAT AS A
TEASER, WE 

1963
01:38:10,200 --> 01:38:14,960
CAN CONTINUE GOING FORWARD.

1964
01:38:14,960 --> 01:38:15,920
SHORT BREAK.

1965
01:38:15,920 --> 01:38:20,440
AT 11:45 WE'LL RECONVENE AND 

1966
01:38:20,440 --> 01:38:24,440
HEAR A PRESENTATION BY DR. TARA 

1967
01:38:24,440 --> 01:38:26,800
SCHWETZ ON ARPA-H WHICH I'M SURE

1968
01:38:26,800 --> 01:38:29,280
YOU WILL ALL FIND EXTREMELY 

1969
01:38:29,280 --> 01:38:29,600
INTERESTING.

1970
01:38:29,600 --> 01:39:09,240
THANKS BACK AT 11:45.

1971
01:39:09,240 --> 01:39:27,320
>>I'LL TURN IT TO TARA.

1972
01:39:27,320 --> 01:39:34,160
>>THIS IS TO CATALYZE
EFFORTS 

1973
01:39:34,160 --> 01:39:35,960
AND ADAM RUSSELL WE'LL MENTION 

1974
01:39:35,960 --> 01:39:43,120
IN A MOMENT IS ON THE CALL HERE.

1975
01:39:43,120 --> 01:39:44,400
I JUST WANT TO PROVIDE A LITTLE 

1976
01:39:44,400 --> 01:39:49,600
BIT OF A BACKGROUND ON THE 

1977
01:39:49,600 --> 01:39:49,800
MODEL.

1978
01:39:49,800 --> 01:39:52,240
ARPA-H WILL BE LEVERAGING AN 

1979
01:39:52,240 --> 01:39:54,200
APPROACH AND HAS BEEN APPLIED IN

1980
01:39:54,200 --> 01:40:00,680
OTHER AREAS OF R&D LIKE THE 

1981
01:40:00,680 --> 01:40:01,960
ENERGY COMMUNITY AND 

1982
01:40:01,960 --> 01:40:12,360
INTELLIGENCE COMMUNITY.

1983
01:40:18,080 --> 01:40:20,560
IS THE MODEL PROMOTES 

1984
01:40:20,560 --> 01:40:22,920
ACCOUNTABILITY THROUGH METRICS 

1985
01:40:22,920 --> 01:40:25,840
AND STAGE GATING WITHIN A LEAN 

1986
01:40:25,840 --> 01:40:27,480
AND NIMBLE ORGANIZATION THAT HAS

1987
01:40:27,480 --> 01:40:29,240
A FAIR AMOUNT OF AUTONOMY.

1988
01:40:29,240 --> 01:40:32,960
IT FOCUSES ON MISSION DRIVEN 

1989
01:40:32,960 --> 01:40:34,560
RATHER THAN REQUIREMENT OR TASK 

1990
01:40:34,560 --> 01:40:38,120
DRIVEN RESEARCH THAT IS BOLD AND

1991
01:40:38,120 --> 01:40:41,560
RISKY AND COULD OFFER A HIGH 

1992
01:40:41,560 --> 01:40:41,800
RETURN.

1993
01:40:41,800 --> 01:40:44,240
IT ADHERES TO URGENT PRINCIPLES 

1994
01:40:44,240 --> 01:40:47,080
THAT ARE APPLIED NOT JUST TO THE

1995
01:40:47,080 --> 01:40:49,360
PROGRAM'S DURATION BUT THE 

1996
01:40:49,360 --> 01:40:51,880
STAFF'S TENURE.

1997
01:40:51,880 --> 01:40:54,240
AND EVERY DECISION AT ARPA-H 

1998
01:40:54,240 --> 01:41:00,000
WILL BE INFORMED BY A MODIFIED 

1999
01:41:00,000 --> 01:41:06,640
VERSION OF WHAT FOLKS AT DARPA 

2000
01:41:06,640 --> 01:41:07,000
HAVE A NAME FOR.

2001
01:41:07,000 --> 01:41:13,480
AND FIRST BEFORE I GET TO THAT 

2002
01:41:13,480 --> 01:41:19,040
IN MORE DETAIL I WANT TO OUTLINE

2003
01:41:19,040 --> 01:41:21,680
THE DRAFT MISSION FOR ARPA-H.

2004
01:41:21,680 --> 01:41:23,000
WHY ARE WE DOING THIS?

2005
01:41:23,000 --> 01:41:26,000
A LITTLE BIT ON THE HOW AND WHAT

2006
01:41:26,000 --> 01:41:27,680
AND WE'LL TALK MORE ABOUT 

2007
01:41:27,680 --> 01:41:29,240
INVESTMENTS LATER ON IN THE 

2008
01:41:29,240 --> 01:41:29,600
PRESENTATION.

2009
01:41:29,600 --> 01:41:33,520
THE IDEA IS TO EMPOWER EVERY 

2010
01:41:33,520 --> 01:41:35,320
AMERICAN TO REALIZE THEIR HEALTH

2011
01:41:35,320 --> 01:41:36,960
POTENTIAL THROUGH PIVOTAL 

2012
01:41:36,960 --> 01:41:39,280
INVESTMENTS IN HIGH-IMPACT 

2013
01:41:39,280 --> 01:41:42,120
SOLUTIONS FOR WELL-DEFINED 

2014
01:41:42,120 --> 01:41:42,560
PROBLEMS.

2015
01:41:42,560 --> 01:41:44,960
THAT PIECE IS CRITICAL BECAUSE 

2016
01:41:44,960 --> 01:41:49,720
WE NEED TO PUT PARAMETERS ON 

2017
01:41:49,720 --> 01:41:54,960
THOSE PROBLEMS.

2018
01:41:54,960 --> 01:41:56,680
THEN DEMONSTRATE WHAT HEALTH 

2019
01:41:56,680 --> 01:42:03,240
FUTURES ARE POSSIBLE FOR ALL.

2020
01:42:03,240 --> 01:42:09,000
DARPA MAKES SEFT -- SET OF A USE

2021
01:42:09,000 --> 01:42:12,120
OF QUESTIONS AND THEY REFERRED 

2022
01:42:12,120 --> 01:42:21,640
TO THEM THE HQs AND THE 

2023
01:42:21,640 --> 01:42:24,640
QUESTIONS HELP AGENCY POTENTIAL 

2024
01:42:24,640 --> 01:42:34,320
S AND THE HEILMEIER QUESTIONS 

2025
01:42:34,320 --> 01:42:36,480
HELP MAKE DECISIONS AND WHAT'S 

2026
01:42:36,480 --> 01:42:41,960
NEW IN THE APPROACH AND IN OTHER

2027
01:42:41,960 --> 01:42:43,480
WORDS, IF YOU'RE SUCCESSFUL WHAT

2028
01:42:43,480 --> 01:42:48,640
WILL BE THE IMPACT?

2029
01:42:48,640 --> 01:42:57,360
THAT IS CRITICAL AND THAT'S 

2030
01:42:57,360 --> 01:43:00,800
CRITICAL TO ARPA-H AND ARPA-H IS

2031
01:43:00,800 --> 01:43:06,360
PROPOSING A REVISED VERSION OF 

2032
01:43:06,360 --> 01:43:14,440
THESE THAT INCLUDES A 

2033
01:43:14,440 --> 01:43:22,960
MODIFICATION TO EQUITY AND IT'S 

2034
01:43:22,960 --> 01:43:23,960
IMPORTANT AND CRITICAL FOR IT TO

2035
01:43:23,960 --> 01:43:27,000
BE LINKED TO DRAW ON THE VAST 

2036
01:43:27,000 --> 01:43:29,760
MOTH AND EXPERTISE AND 

2037
01:43:29,760 --> 01:43:34,000
INFRASTRUCTURE THAT EXISTS AT 

2038
01:43:34,000 --> 01:43:34,200
NIH.

2039
01:43:34,200 --> 01:43:36,160
HOWEVER, I THINK THERE'S ROBUST 

2040
01:43:36,160 --> 01:43:38,200
AGREEMENT IT IS AND WILL REMAIN 

2041
01:43:38,200 --> 01:43:42,640
DISTINCT WITH ITS OWN UNIQUE 

2042
01:43:42,640 --> 01:43:47,480
CULTURE, ORGANIZATION AND 

2043
01:43:47,480 --> 01:43:47,760
AUTONOMY.

2044
01:43:47,760 --> 01:43:48,920
ECHOING MANY ELEMENTS OF THE 

2045
01:43:48,920 --> 01:43:50,640
MODEL ARPA-H WILL SEEK TO BRING 

2046
01:43:50,640 --> 01:43:53,880
ON THE MOST INNOVATIVE PEOPLE 

2047
01:43:53,880 --> 01:43:56,160
WITH THE MOST NOVEL IDEAS.

2048
01:43:56,160 --> 01:43:58,000
THAT WILL FORM ROBUSTLY DIVERSE 

2049
01:43:58,000 --> 01:44:00,560
AND COLLABORATIVE TEAMS.

2050
01:44:00,560 --> 01:44:02,440
THE PROGRAM MANAGERS TO BE PART 

2051
01:44:02,440 --> 01:44:08,400
OF THE TEAM ARE LIKELY TO BE 

2052
01:44:08,400 --> 01:44:08,680
UNCOMMON.

2053
01:44:08,680 --> 01:44:09,840
THEY NEED TO BE TECHNICAL 

2054
01:44:09,840 --> 01:44:12,800
EXPERTS AND PROGRAMMATIC 

2055
01:44:12,800 --> 01:44:13,680
VISIONARIES.

2056
01:44:13,680 --> 01:44:17,440
EQUITY IS GOING TO BE CONSIDERED

2057
01:44:17,440 --> 01:44:21,400
AN ESSENTIAL ELEMENT AND KEY IN 

2058
01:44:21,400 --> 01:44:23,280
INTERNAL PRACTICES.

2059
01:44:23,280 --> 01:44:26,080
THE PEOPLE THAT ARPA-H HIRES 

2060
01:44:26,080 --> 01:44:28,520
INCLUDING PROGRAM MANAGERS, THE 

2061
01:44:28,520 --> 01:44:29,720
PROGRAMS IT SUPPORTS AND THE 

2062
01:44:29,720 --> 01:44:39,480
PERFORMERS IT MAKES AWARDS.

2063
01:44:39,480 --> 01:44:40,560
ANOTHER PRINCIPLE IN DRIVING 

2064
01:44:40,560 --> 01:44:43,200
ARPA-H IS IT WILL BE NIMBLE AND 

2065
01:44:43,200 --> 01:44:47,440
LEAN IN ITS ORGANIZATIONAL 

2066
01:44:47,440 --> 01:44:52,360
STRUCTURE AND OPERATIONALIZING 

2067
01:44:52,360 --> 01:44:57,520
IT'S PORTFOLIO AND BUSINESS 

2068
01:44:57,520 --> 01:45:02,400
PRACTICES AND THE DIRECTION FOR 

2069
01:45:02,400 --> 01:45:03,920
THE TENURE OF PEOPLE THERE AND 

2070
01:45:03,920 --> 01:45:06,320
WILL DO SO IN A WAY THAT'S 

2071
01:45:06,320 --> 01:45:12,960
DYNAMIC AND EVOLVING AND 

2072
01:45:12,960 --> 01:45:13,320
ADAPTIVE.

2073
01:45:13,320 --> 01:45:15,640
AND BE OPEN AND TRANSPARENT 

2074
01:45:15,640 --> 01:45:18,080
ABOUT THE PROCESSES IT USES AND 

2075
01:45:18,080 --> 01:45:20,240
ENGAGE STAKEHOLDERS ACROSS A 

2076
01:45:20,240 --> 01:45:22,800
RANGE OF SECTORS AND DISCIPLINE 

2077
01:45:22,800 --> 01:45:32,880
EARLY AND OFTEN TO HELP INFORM 

2078
01:45:32,880 --> 01:45:36,280
AND PROMOTE INDEPENDENCE AND 

2079
01:45:36,280 --> 01:45:39,120
ACCOUNTABILITY REENFORCED BY THE

2080
01:45:39,120 --> 01:45:43,440
AMBITIOUS MILESTONES AND METRICS

2081
01:45:43,440 --> 01:45:45,800
AND SEEK TO HAVE PROGRAMS THAT 

2082
01:45:45,800 --> 01:45:47,200
COULD OFFER OUTSIZED IMPACT OR 

2083
01:45:47,200 --> 01:45:47,960
RETURN.

2084
01:45:47,960 --> 01:45:48,960
AND NORMALIZE THE FACT THAT NOT 

2085
01:45:48,960 --> 01:45:51,400
ALL OF THESE ARE GOING TO BE 

2086
01:45:51,400 --> 01:45:58,640
SUCCESSFUL IS A CRITICAL POINT.

2087
01:45:58,640 --> 01:46:00,480
TO TALK BRIEFLY ABOUT THE 

2088
01:46:00,480 --> 01:46:05,480
LEGISLATIVE STATUS AND WHERE 

2089
01:46:05,480 --> 01:46:15,160
THEY STAND WITH ARPA-H.

2090
01:46:15,160 --> 01:46:17,600
TALK ABOUT THE LEAD UP AND SINCE

2091
01:46:17,600 --> 01:46:19,040
RECEIVING FUND FROM THE OMNIBUS.

2092
01:46:19,040 --> 01:46:22,160
LAST SUMMER OSTP AND NIH 

2093
01:46:22,160 --> 01:46:25,880
OUTLINED A VISION FOR ARPA-H AND

2094
01:46:25,880 --> 01:46:28,640
SOUGHT FEEDBACK FROM A LOT OF 

2095
01:46:28,640 --> 01:46:31,840
PEOPLE ON THIS CALL EVEN AND 

2096
01:46:31,840 --> 01:46:38,680
WE'RE FAST FORWARDING TO EARLIER

2097
01:46:38,680 --> 01:46:39,840
THIS YEAR WHERE ARPA-H WAS 

2098
01:46:39,840 --> 01:46:44,640
INCLUDED IN THE OMNIBUS.

2099
01:46:44,640 --> 01:46:54,160
I'LL HIGHLIGHT SOME PROVISIONS.

2100
01:46:54,160 --> 01:46:55,760
IT WAS FUNDED AT A BILLION 

2101
01:46:55,760 --> 01:46:57,040
DOLLARS AVAILABLE FOR THREE 

2102
01:46:57,040 --> 01:47:07,160
YEARS.

2103
01:47:16,720 --> 01:47:19,120
IT PROVIDED A HIGHER MECHANISM 

2104
01:47:19,120 --> 01:47:26,920
WITH HIGHER COMPENSATION RATES.

2105
01:47:26,920 --> 01:47:28,640
IT GAVE THE SECRETARY TO 

2106
01:47:28,640 --> 01:47:29,680
CONTROVERSY IT WITHIN NIH AND 

2107
01:47:29,680 --> 01:47:32,640
THAT DECISION WAS MADE AND 

2108
01:47:32,640 --> 01:47:34,400
ARPA-H WAS TRANSFERRED AND 

2109
01:47:34,400 --> 01:47:42,120
ESTABLISHED WITHIN NIH.

2110
01:47:42,120 --> 01:47:43,200
THERE'S A LOT OF WORK THAT GOES 

2111
01:47:43,200 --> 01:47:45,680
TO STANDING UP A NEW 

2112
01:47:45,680 --> 01:47:46,600
ORGANIZATION.

2113
01:47:46,600 --> 01:47:48,320
I'LL BRIEFLY WALK YOU THROUGH 

2114
01:47:48,320 --> 01:47:50,360
THE ORGANIZATIONAL STATUS OF 

2115
01:47:50,360 --> 01:47:50,600
ARPA-H.

2116
01:47:50,600 --> 01:47:54,360
AS MENTIONED SINCE THE OMNIBUS 

2117
01:47:54,360 --> 01:47:55,680
IT WAS TRANSFERRED TO AND 

2118
01:47:55,680 --> 01:47:56,840
ESTABLISHED TO NIH.

2119
01:47:56,840 --> 01:48:00,360
THE PRESIDENT REQUESTED $5 

2120
01:48:00,360 --> 01:48:01,800
BILLION IN THE FY23 BUDGET TO 

2121
01:48:01,800 --> 01:48:08,440
HELP GROW ARPA-H.

2122
01:48:08,440 --> 01:48:09,720
I'LL TALK ABOUT THE OTHER 

2123
01:48:09,720 --> 01:48:10,280
PROGRESS WITH LEADERSHIP IN 

2124
01:48:10,280 --> 01:48:20,440
MOMENTS.

2125
01:48:21,560 --> 01:48:27,760
ARPA-H AND NIH WILL NEED TO BE 

2126
01:48:27,760 --> 01:48:32,400
SYNERGISTIC IN PRELS  PRINCIPLES

2127
01:48:32,400 --> 01:48:35,200
AND FOCUS AND HAVE THE 

2128
01:48:35,200 --> 01:48:36,440
INFRASTRUCTURE AVAILABLE HERE.

2129
01:48:36,440 --> 01:48:39,160
IT WILL RELY ON NIH FOR SOME OF 

2130
01:48:39,160 --> 01:48:41,720
THE FUNCTIONS LISTED ON THE 

2131
01:48:41,720 --> 01:48:44,240
SLIDE AND THIS GETS INTO THE 

2132
01:48:44,240 --> 01:48:45,800
WEEDS QUICKLY BUT WE THINK ABOUT

2133
01:48:45,800 --> 01:48:52,680
THINGS LIKE THE BUDGET SYSTEMS 

2134
01:48:52,680 --> 01:48:56,760
CYBER AND PHYSICAL SECURITY AND 

2135
01:48:56,760 --> 01:49:00,040
THE I.T. THAT ALLOWS WORK TO BE 

2136
01:49:00,040 --> 01:49:00,600
ACCOMPLISHED AND MANY MORE 

2137
01:49:00,600 --> 01:49:08,200
FUNCTIONS.

2138
01:49:08,200 --> 01:49:09,600
THE FOCUS WILL BE ON BUILDING 

2139
01:49:09,600 --> 01:49:12,200
OUT PATHWAYS AND LAY THE GROUND 

2140
01:49:12,200 --> 01:49:13,800
WORK FOR THE VARIOUS PROCESSES, 

2141
01:49:13,800 --> 01:49:17,240
POLICIES AND FUNCTIONS THAT 

2142
01:49:17,240 --> 01:49:22,400
ARPA-H MIGHT WISH TO EITHER 

2143
01:49:22,400 --> 01:49:23,280
ADOPT, ADAPT OR BUILD FROM 

2144
01:49:23,280 --> 01:49:28,080
SCRATCH.

2145
01:49:28,080 --> 01:49:29,360
WE HAVE A GROWING TEAM THAT'S 

2146
01:49:29,360 --> 01:49:31,640
BEEN PLANNING FOR THE STAND UP 

2147
01:49:31,640 --> 01:49:34,000
OF ARPA-H FOR THE PAST FEW 

2148
01:49:34,000 --> 01:49:36,160
MONTHS AND FOCUSSING ON DOING 

2149
01:49:36,160 --> 01:49:38,600
NEEDS ASSESSMENTS AND 

2150
01:49:38,600 --> 01:49:43,000
REQUIREMENTS GATHERING AND IN 

2151
01:49:43,000 --> 01:49:44,200
SEVERAL KEY FOCUS AREAS.

2152
01:49:44,200 --> 01:49:47,960
THESE RANGE FROM ACQUISITION TO 

2153
01:49:47,960 --> 01:49:50,480
CONTRACTING TO BUDGET STRATEGIC 

2154
01:49:50,480 --> 01:49:52,640
PLANNING AND STRATEGY RESOURCE 

2155
01:49:52,640 --> 01:49:55,880
DEVELOPMENT AND LOTS OF OTHER 

2156
01:49:55,880 --> 01:49:59,840
AREAS AS WELL AND WITH THE 

2157
01:49:59,840 --> 01:50:02,120
PASSAGE OF THE FY22 OMNIBUS 

2158
01:50:02,120 --> 01:50:04,200
WHERE WE RECEIVED RESOURCES, 

2159
01:50:04,200 --> 01:50:09,360
WE'RE STARTING TO TURN ATTENTION

2160
01:50:09,360 --> 01:50:15,000
TO IMPLEMENTATION.

2161
01:50:15,000 --> 01:50:18,320
I'M NOT GOING TO DO INTO A LOT 

2162
01:50:18,320 --> 01:50:21,320
OF DETAIL BUT TO HIGHLIGHT THE 

2163
01:50:21,320 --> 01:50:23,560
FOCUS AND WORK GOING IN THE 

2164
01:50:23,560 --> 01:50:27,640
AREAS INCLUDING ACTIVITIES TO 

2165
01:50:27,640 --> 01:50:32,080
DEVELOP PROGRAM MANAGER 

2166
01:50:32,080 --> 01:50:32,320
PROCESSES.

2167
01:50:32,320 --> 01:50:36,440
HOW TO LAUNCH PROGRAMS AND 

2168
01:50:36,440 --> 01:50:41,760
ANALYZE DATA FROM PROCESSES AND 

2169
01:50:41,760 --> 01:50:44,720
PROGRAMS IS AN IMPORTANT FEATURE

2170
01:50:44,720 --> 01:50:51,000
TO ARPA-H WILL BE A ROBUST 

2171
01:50:51,000 --> 01:50:53,480
SYSTEM TO CAPTURE AND ANALYZE 

2172
01:50:53,480 --> 01:50:55,480
DATA SO IT BE EVIDENCE TO 

2173
01:50:55,480 --> 01:50:56,720
SUPPORT DECISION MAKING IN REAL 

2174
01:50:56,720 --> 01:51:03,880
TIME.

2175
01:51:03,880 --> 01:51:06,880
AND ROBUST VIRTUALIZATION 

2176
01:51:06,880 --> 01:51:11,640
PROGRAM WE'LL BE ABLE TO BUILD 

2177
01:51:11,640 --> 01:51:13,320
OUT AND HIRE EXCEPTIONAL PEOPLE 

2178
01:51:13,320 --> 01:51:15,440
AND GETTING THEM UP AND RUNNING 

2179
01:51:15,440 --> 01:51:16,840
QUICKLY AND BUILDING OUT A 

2180
01:51:16,840 --> 01:51:18,160
DYNAMIC AND INNOVATIVE 

2181
01:51:18,160 --> 01:51:19,560
CONTRACTING JOB AND DOING ALL 

2182
01:51:19,560 --> 01:51:23,000
THESE THINGS IN A REALLY 

2183
01:51:23,000 --> 01:51:24,520
ORGANIZED MANNER THAT CONSIDERS 

2184
01:51:24,520 --> 01:51:28,640
CHANGE MANAGEMENT AND THE 

2185
01:51:28,640 --> 01:51:34,080
CULTURE WE'D LIKE TO BUILD FOR 

2186
01:51:34,080 --> 01:51:35,880
ARPA-H AN IMPORTANT FEATURE WILL

2187
01:51:35,880 --> 01:51:42,920
BE IDENTIFYING LEADERSHIP FOR 

2188
01:51:42,920 --> 01:51:50,960
ARPA-H WITH ARPA EXPERIENCE.

2189
01:51:50,960 --> 01:51:53,400
HOPING TO SEE PROGRESS IN MOVING

2190
01:51:53,400 --> 01:51:55,000
FORWARD WITH THE APPOINTMENT OF 

2191
01:51:55,000 --> 01:52:00,640
AN INAUGURAL DIRECTOR THROUGH A 

2192
01:52:00,640 --> 01:52:08,080
PRESIDENTIAL APPOINTMENT.

2193
01:52:08,080 --> 01:52:16,520
EMPOWER A COHORT OF DIVERSE 

2194
01:52:16,520 --> 01:52:18,080
STAFF AND SET OUT THE 

2195
01:52:18,080 --> 01:52:22,720
ORGANIZATION AND THEY'LL OUTLINE

2196
01:52:22,720 --> 01:52:30,840
THE SCIENTIFIC FOCUS OF ARPA-H.

2197
01:52:30,840 --> 01:52:32,320
THERE'S THE TYPES OF PERSONS WE 

2198
01:52:32,320 --> 01:52:34,120
MIGHT WANT TO RECRUIT OR 

2199
01:52:34,120 --> 01:52:37,200
HOPEFULLY HAVE IN THIS POSITION 

2200
01:52:37,200 --> 01:52:38,920
AND GOING TO NEED TO BE AN 

2201
01:52:38,920 --> 01:52:40,440
EXTRAORDINARY LEADER WITH A 

2202
01:52:40,440 --> 01:52:42,400
PROVEN TRACK RECORD AND VISION 

2203
01:52:42,400 --> 01:52:47,440
FOR DRIVING TRANSFORMATIVE 

2204
01:52:47,440 --> 01:52:52,080
CHANGE IN HEALTH OR BIO 

2205
01:52:52,080 --> 01:52:52,320
MEDICINE.

2206
01:52:52,320 --> 01:52:57,760
IT WOULD BE GREAT IF THEY SPENT 

2207
01:52:57,760 --> 01:53:00,480
TIME IN ACADEMIA AND UNDERSTAND 

2208
01:53:00,480 --> 01:53:03,000
THE ENVIRONMENT THEY'LL BE 

2209
01:53:03,000 --> 01:53:04,160
COMING INTO MORE THOROUGHLY AND 

2210
01:53:04,160 --> 01:53:13,040
TO BE A DIPLOMATIC AND ADVOCATE.

2211
01:53:13,040 --> 01:53:16,680
IT WILL BE A KEY ELEMENT TO 

2212
01:53:16,680 --> 01:53:20,080
ARPA-H'S SUCCESS.

2213
01:53:20,080 --> 01:53:27,280
A COUPLE WEEKS AGO WE ANNOUNCED 

2214
01:53:27,280 --> 01:53:29,280
ADAM RUSSELL AS THE ACTING 

2215
01:53:29,280 --> 01:53:30,720
DEPUTY DIRECTOR OF ARPA-H.

2216
01:53:30,720 --> 01:53:32,640
HE WAS THE CHIEF SCIENTIST AT 

2217
01:53:32,640 --> 01:53:40,720
THE UNIVERSITY OF MARYLAND AND A

2218
01:53:40,720 --> 01:53:43,480
FORMER DARPA PROGRAM MANAGER AND

2219
01:53:43,480 --> 01:53:47,040
FAMILIAR WITH THE MODEL ARPA-H 

2220
01:53:47,040 --> 01:53:48,520
IS BEING BASED ON.

2221
01:53:48,520 --> 01:53:50,320
HE UNDERSTANDS THE CULTURE AND 

2222
01:53:50,320 --> 01:53:53,080
PRINCIPLES WE WANT TO BUILD.

2223
01:53:53,080 --> 01:54:00,120
HE'S A SOCIAL ANTHROPOLOGIST BY 

2224
01:54:00,120 --> 01:54:10,280
TRAINING.

2225
01:55:37,040 --> 01:55:38,680
ONE OF THE OTHER MILESTONES IS 

2226
01:55:38,680 --> 01:55:40,320
THE RECEIPT OF A PROFESSIONAL 

2227
01:55:40,320 --> 01:55:43,280
HEAD OF CONTRACTING ACTIVITY OR 

2228
01:55:43,280 --> 01:55:45,160
HCA WHICH WILL GIVE IT A LOT OF 

2229
01:55:45,160 --> 01:55:46,440
FLEXIBILITY AND INDEPENDENCE TO 

2230
01:55:46,440 --> 01:55:49,480
MAKE THE AWARD.

2231
01:55:49,480 --> 01:55:51,960
IT'S VERY INSIDE BASEBALL, IF 

2232
01:55:51,960 --> 01:55:54,520
YOU WILL, AND VERY MUCH A 

2233
01:55:54,520 --> 01:55:56,400
PROCESS THAT NEEDS TO OCCUR BUT 

2234
01:55:56,400 --> 01:55:57,120
IT'S GOING TO BE A CRITICAL 

2235
01:55:57,120 --> 01:56:03,680
FUNCTION FOR ARPA-H.

2236
01:56:03,680 --> 01:56:04,920
WORKING THROUGH OTHER PLANS FOR 

2237
01:56:04,920 --> 01:56:06,080
OPERATIONS AND THE FUNCTIONAL 

2238
01:56:06,080 --> 01:56:09,920
AREAS I MENTIONED PREVIOUSLY.

2239
01:56:09,920 --> 01:56:12,560
WORKING TOWARDS PUBLISHING THE 

2240
01:56:12,560 --> 01:56:19,280
FIRST BROAD AGENCY ANNOUNCEMENT.

2241
01:56:19,280 --> 01:56:20,960
WE HAVE SEEN HOW SUCCESSFUL IT'S

2242
01:56:20,960 --> 01:56:26,240
BEEN AT DARPA AND OTHER ARPAs 

2243
01:56:26,240 --> 01:56:28,840
ACROSS THE FEDERAL AND SO MANY 

2244
01:56:28,840 --> 01:56:31,240
AREAS ARE RIPE FOR 

2245
01:56:31,240 --> 01:56:32,160
TRANSFORMATION AND SO MANY 

2246
01:56:32,160 --> 01:56:32,920
POTENTIAL OPPORTUNITIES TO SHAPE

2247
01:56:32,920 --> 01:56:35,320
THE FUTURE OF HEALTH AND 

2248
01:56:35,320 --> 01:56:37,640
MEDICINE AND SIGNIFICANTLY 

2249
01:56:37,640 --> 01:56:40,640
IMPROVE THE QUALITY OF LIFE FOR 

2250
01:56:40,640 --> 01:56:50,880
ALL AMERICANS.

2251
01:56:57,800 --> 01:56:59,000
I'M EXCITED TO SEE HOW TOMORROW 

2252
01:56:59,000 --> 01:57:09,080
GROW.

2253
01:57:15,160 --> 01:57:15,720
SHELLY, DO YOU WANT TO MAKE A 

2254
01:57:15,720 --> 01:57:21,400
COMMENT?

2255
01:57:21,400 --> 01:57:31,960
>> IT'S AN EXCITING
INITIATIVE 

2256
01:57:33,720 --> 01:57:37,120
AND LOOKING TO LARRY'S PREVIOUS 

2257
01:57:37,120 --> 01:57:41,360
COMMENTS TO TRY TO BUILD IN 

2258
01:57:41,360 --> 01:57:42,440
TREMENDOUS DIVERSITY IN THE WAY 

2259
01:57:42,440 --> 01:57:44,880
THIS IS IMPLEMENTED SINCE IT'S 

2260
01:57:44,880 --> 01:57:49,040
GOING BE PROBABLY THE BIGGEST 

2261
01:57:49,040 --> 01:57:51,160
INITIATIVE THAT'S COME FOR A 

2262
01:57:51,160 --> 01:57:52,960
WHILE AND WILL BE COMING.

2263
01:57:52,960 --> 01:57:54,560
I WONDERED WHAT YOUR THOUGHTS 

2264
01:57:54,560 --> 01:58:00,720
WERE ABOUT THAT AND HOW TO 

2265
01:58:00,720 --> 01:58:04,800
IMPLEMENT.

2266
01:58:04,800 --> 01:58:09,160
>> IN SOME SENSE WE GET TO
START

2267
01:58:09,160 --> 01:58:14,480
A LITTLE BIT FROM SCRATCH AND SO

2268
01:58:14,480 --> 01:58:24,280
WE'RE TAKING THINGS IN AN IDEAL 

2269
01:58:24,280 --> 01:58:28,280
WAY AND BRACE IT THROUGH DYNAMIC

2270
01:58:28,280 --> 01:58:29,080
OPTIMIZATION ELEMENTS WE WANT TO

2271
01:58:29,080 --> 01:58:30,600
EMBRACE FOR ALL THE PROCESSES 

2272
01:58:30,600 --> 01:58:32,640
FOR ARPA-H.

2273
01:58:32,640 --> 01:58:35,600
WHAT THAT MEANS PRACTICALLY IN 

2274
01:58:35,600 --> 01:58:37,000
THIS AREA IN PARTICULAR IS THAT 

2275
01:58:37,000 --> 01:58:38,840
WE'RE GOING TO BE CONSTANTLY 

2276
01:58:38,840 --> 01:58:40,200
EVOLVING AND LEARNING AND TRYING

2277
01:58:40,200 --> 01:58:42,040
THINGS AND SEEING IF WE'RE BEING

2278
01:58:42,040 --> 01:58:43,040
SUCCESSFUL IN THE DIFFERENT 

2279
01:58:43,040 --> 01:58:52,120
APPROACHES WE USE.

2280
01:58:52,120 --> 01:58:53,360
HOPEFULLY A LEARNING OPPORTUNITY

2281
01:58:53,360 --> 01:58:54,160
NOT JUST FOR ARPA-H BUT MORE 

2282
01:58:54,160 --> 01:59:04,320
BROADLY.

2283
01:59:04,680 --> 01:59:05,920
I SEE A QUESTION FROM HOWARD 

2284
01:59:05,920 --> 01:59:06,280
CHANG.

2285
01:59:06,280 --> 01:59:08,040
>> I WAS GOING TO ASK
WHETHER 

2286
01:59:08,040 --> 01:59:10,160
THE PROGRAM OFFICERS WHICH IS 

2287
01:59:10,160 --> 01:59:13,240
KEY TO ARPA-H, THE HIRING WILL 

2288
01:59:13,240 --> 01:59:15,680
COME FROM NIH OR OUTSIDE 

2289
01:59:15,680 --> 01:59:16,120
ORGANIZATION.

2290
01:59:16,120 --> 01:59:18,760
IS THERE A CONCERN OF A BRAIN 

2291
01:59:18,760 --> 01:59:20,040
DRAIN OR CHANGING THE CHARACTER 

2292
01:59:20,040 --> 01:59:21,880
OF THE TWO ORGANIZATIONS AS A 

2293
01:59:21,880 --> 01:59:22,080
RESULT?

2294
01:59:22,080 --> 01:59:32,560
>> THAT'S A GREAT
QUESTION.

2295
01:59:37,600 --> 01:59:39,760
THESE ARE SHORTER TERM POSITIONS

2296
01:59:39,760 --> 01:59:43,280
COMING ON BOARD THE TO SIX YEARS

2297
01:59:43,280 --> 01:59:45,520
AT A TIME.

2298
01:59:45,520 --> 01:59:48,560
HOPEFULLY BE THE ROBUST CHURNING

2299
01:59:48,560 --> 01:59:53,800
OF PROGRAM MANAGERS THAT COME 

2300
01:59:53,800 --> 01:59:54,040
IN.

2301
01:59:54,040 --> 01:59:55,160
THERE ARE OPPORTUNITIES AND ON 

2302
01:59:55,160 --> 01:59:57,200
THE OPERATIONAL SIDE OF THINGS 

2303
01:59:57,200 --> 02:00:00,800
WHERE IT MAY BE A VALUE TO HAVE 

2304
02:00:00,800 --> 02:00:01,440
INSTITUTIONAL KNOWLEDGE FROM 

2305
02:00:01,440 --> 02:00:03,480
SOME NIH STAFF BUT AGAIN WE WANT

2306
02:00:03,480 --> 02:00:07,480
TO THINK BROADLY AND ROBUSTLY 

2307
02:00:07,480 --> 02:00:10,560
AND PULL IN PEOPLE WHO ARE 

2308
02:00:10,560 --> 02:00:14,240
FAMILIAR WITH THIS ARPA-H MODEL.

2309
02:00:14,240 --> 02:00:16,400
AND PEOPLE WHO HAVE EXPERIENCE 

2310
02:00:16,400 --> 02:00:20,640
THAT IS EVEN OUTSIDE OF THE 

2311
02:00:20,640 --> 02:00:23,360
TRADITIONAL PATHWAYS WE THINK OF

2312
02:00:23,360 --> 02:00:24,520
WITH THE BIOMEDICAL AND HEALTH 

2313
02:00:24,520 --> 02:00:25,240
COMMUNITY.

2314
02:00:25,240 --> 02:00:25,840
PEOPLE TO BRING IN NEW 

2315
02:00:25,840 --> 02:00:33,680
PERSPECTIVES TO THE FIELD.

2316
02:00:33,680 --> 02:00:35,600
>> THANK YOU.

2317
02:00:35,600 --> 02:00:39,040
>> THEY HIRED AN
ANTHROPOLOGIST 

2318
02:00:39,040 --> 02:00:42,080
AS AN NIH DIRECTOR IS CRAZY.

2319
02:00:42,080 --> 02:00:44,640
>> THAT'S ADAM RUSSELL FOR
FOLKS

2320
02:00:44,640 --> 02:00:48,360
WHO ARE UNAWARE.

2321
02:00:48,360 --> 02:00:52,160
IT JUST SAYS ADAM'S iPHONE.

2322
02:00:52,160 --> 02:00:54,720
>> ADAM IS CRAZY OR THE
HIRING 

2323
02:00:54,720 --> 02:00:57,240
OF ADAM IS CRAZY.

2324
02:00:57,240 --> 02:00:59,440
>> TBD.

2325
02:00:59,440 --> 02:01:01,280
IT'S AN EMPIRICAL QUESTION.

2326
02:01:01,280 --> 02:01:04,560
>> TARA, I THINK WE LOST 

2327
02:01:04,560 --> 02:01:06,560
CHRISTINA FOR SOME DUTY SHE 

2328
02:01:06,560 --> 02:01:10,320
NEEDED TO PERFORM BUT REMINDS US

2329
02:01:10,320 --> 02:01:13,720
SHE HELPED SET UP ARPA-H AT THE 

2330
02:01:13,720 --> 02:01:17,000
DOE IN 2009 AND HAS SOME UNIQUE 

2331
02:01:17,000 --> 02:01:22,720
INSIGHTS TO ALL OF THIS.

2332
02:01:22,720 --> 02:01:25,120
IF YOU INTERACTED WITH THE 

2333
02:01:25,120 --> 02:01:26,560
ARPA-H DEPUTY IN THE CHAT BOX.

2334
02:01:26,560 --> 02:01:29,440
>> WHILE AT OSTP I NOT
ONLY 

2335
02:01:29,440 --> 02:01:31,080
TOUCHED BASE WITH HER BUT MANY 

2336
02:01:31,080 --> 02:01:34,440
PEOPLE SHE SUGGESTED I REACH OUT

2337
02:01:34,440 --> 02:01:37,680
TO SHE WAS INCREDIBLY HELPFUL TO

2338
02:01:37,680 --> 02:01:43,600
ME IN PROVIDING LESSONS LEARNED 

2339
02:01:43,600 --> 02:01:51,160
AND DEPUTY DIRECTOR FOR 

2340
02:01:51,160 --> 02:01:53,400
OPERATIONS AT ARPA-E.

2341
02:01:53,400 --> 02:01:55,040
HE HAS BEEN AN AMAZING RESOURCE.

2342
02:01:55,040 --> 02:01:58,520
I DON'T KNOW IF HE WAS EMPLOYEE 

2343
02:01:58,520 --> 02:02:03,480
NUMBER ONE BUT CLOSE TO IT AND 

2344
02:02:03,480 --> 02:02:05,640
HAS HAD A LOT OF VERY HELPFUL 

2345
02:02:05,640 --> 02:02:06,160
ADVICE.

2346
02:02:06,160 --> 02:02:08,640
I APPRECIATE ALL SHE'S DONE 

2347
02:02:08,640 --> 02:02:12,240
PREVIOUSLY AND CONTINUES TO DO.

2348
02:02:12,240 --> 02:02:13,160
>> OKAY.

2349
02:02:13,160 --> 02:02:15,320
THANKS DAVID FOR THE PROMPT.

2350
02:02:15,320 --> 02:02:16,640
WE'LL TAKE THE SLIDES DOWN 

2351
02:02:16,640 --> 02:02:27,160
DURING THE DISCUSSION PERIOD.

2352
02:02:33,160 --> 02:02:34,840
>> THERE'S INITIATIVES
FROM 

2353
02:02:34,840 --> 02:02:35,840
OTHER INSTITUTES.

2354
02:02:35,840 --> 02:02:38,360
I'M TRYING TO THINK, WILL THERE 

2355
02:02:38,360 --> 02:02:43,120
BE A MECHANISM BY WHICH THERE'S 

2356
02:02:43,120 --> 02:02:44,720
COORDINATION BETWEEN THE BROAD 

2357
02:02:44,720 --> 02:02:47,600
AGENCY ANNOUNCEMENTS FROM ARPA-H

2358
02:02:47,600 --> 02:02:50,320
VERSUS WHAT'S COMING UP ALL THE 

2359
02:02:50,320 --> 02:02:56,040
TIME FROM SOME OTHER INSTITUTES 

2360
02:02:56,040 --> 02:02:56,400
AS WELL?

2361
02:02:56,400 --> 02:02:58,040
SOMETIMES THE SAME LANGUAGE IS 

2362
02:02:58,040 --> 02:02:58,360
USED.

2363
02:02:58,360 --> 02:03:03,400
>> I THINK SOME OF THE 

2364
02:03:03,400 --> 02:03:06,120
DIFFERENCES BETWEEN SOME OF THE 

2365
02:03:06,120 --> 02:03:10,440
FUNCTIONS OF NIH AND ARPA-H IS A

2366
02:03:10,440 --> 02:03:12,120
LITTLE BIT ON THE APPROACH.

2367
02:03:12,120 --> 02:03:13,440
IT WILL BE DIFFERENT BUT ALSO ON

2368
02:03:13,440 --> 02:03:15,920
SOME OF THE TYPES OF THINGS 

2369
02:03:15,920 --> 02:03:17,840
WE'LL BE WORKING ON.

2370
02:03:17,840 --> 02:03:22,080
TO YOUR POINT ABOUT HOW ARPA-H 

2371
02:03:22,080 --> 02:03:23,920
PLANS TO COORDINATE ACROSS NIH 

2372
02:03:23,920 --> 02:03:27,640
WITH THE NIH INSTITUTES AND 

2373
02:03:27,640 --> 02:03:29,760
CENTERS, IN TERMS OF PROGRAM 

2374
02:03:29,760 --> 02:03:32,600
DEVELOPMENT, IT'S GOING TO BE A 

2375
02:03:32,600 --> 02:03:36,640
VERY ENGAGED ITERATIVE PROCESS 

2376
02:03:36,640 --> 02:03:40,640
THAT WILL REQUIRE AND 

2377
02:03:40,640 --> 02:03:42,240
NECESSITATE A LOT OF INTERACTION

2378
02:03:42,240 --> 02:03:44,520
WITH PEOPLE ACROSS THE COMMUNITY

2379
02:03:44,520 --> 02:03:46,240
AND OBVIOUSLY INCLUDING NIH.

2380
02:03:46,240 --> 02:03:51,560
I GREAT STARTING POINT ALL THE 

2381
02:03:51,560 --> 02:04:01,240
TIME IS GOING TO BE JUST WHAT IS

2382
02:04:01,240 --> 02:04:11,800
NIH DOING AND BE PUSHING FORWARD

2383
02:04:11,800 --> 02:04:15,240
TO CATALYZE WHAT IS TRYING TO BE

2384
02:04:15,240 --> 02:04:16,440
LARGE IN THINKING.

2385
02:04:16,440 --> 02:04:19,800
WE WANT TO MAKE SURE WE'RE 

2386
02:04:19,800 --> 02:04:21,720
ASKING VERY HIGH-LEVEL BUT 

2387
02:04:21,720 --> 02:04:24,320
DISTINCT AND WELL-DEFINED 

2388
02:04:24,320 --> 02:04:31,360
QUESTIONS TO CHALLENGES THAT 

2389
02:04:31,360 --> 02:04:37,320
HAVE HERETOFORE BEEN DIFFICULT 

2390
02:04:37,320 --> 02:04:47,560
TO ACCOMPLISH.

2391
02:04:48,440 --> 02:04:49,960
>> HOW'S IT BEING TODAY
AND 

2392
02:04:49,960 --> 02:04:51,680
IMPOSSIBLE AND FIND OUT WHO IS 

2393
02:04:51,680 --> 02:04:53,440
DOING STUFF IN THE AREA ALREADY 

2394
02:04:53,440 --> 02:04:55,000
AND WHERE ARE THEY STRUGGLING.

2395
02:04:55,000 --> 02:04:57,280
IT'S NOT LIKE WE'RE GOING TO DO 

2396
02:04:57,280 --> 02:04:58,400
BETTER THAN WE ARE.

2397
02:04:58,400 --> 02:05:00,120
IT'S A FUNDAMENTAL CHALLENGE IF 

2398
02:05:00,120 --> 02:05:04,080
WE CAN GET OVER THAT, IT WOULD 

2399
02:05:04,080 --> 02:05:05,320
ACCELERATE EVERYBODY'S 

2400
02:05:05,320 --> 02:05:06,960
CAPABILITIES AND EMPOWER THEM 

2401
02:05:06,960 --> 02:05:08,280
AND SO WHAT'S NEW?

2402
02:05:08,280 --> 02:05:10,560
WHAT IS ARPA-H GOING TO ADD TO 

2403
02:05:10,560 --> 02:05:11,920
THE ONGOING CONVERSATION, 

2404
02:05:11,920 --> 02:05:13,960
EFFORT, RESEARCH, PROJECT, 

2405
02:05:13,960 --> 02:05:14,240
ETCETERA.

2406
02:05:14,240 --> 02:05:16,600
WE CAN'T ANSWER THAT, WE DON'T 

2407
02:05:16,600 --> 02:05:17,320
MOVE OUT.

2408
02:05:17,320 --> 02:05:18,960
THAT'S HOW IT'S BAKED IN TO MAKE

2409
02:05:18,960 --> 02:05:20,400
SURE WE'RE NOT MAKING THINGS UP 

2410
02:05:20,400 --> 02:05:21,040
ON OUR OWN.

2411
02:05:21,040 --> 02:05:23,760
I HOPE THAT HELPS.

2412
02:05:23,760 --> 02:05:25,760
>> THEY'LL HAVE TO JUSTIFY
WHAT 

2413
02:05:25,760 --> 02:05:28,160
THEY'RE DOING AND WHY.

2414
02:05:28,160 --> 02:05:29,880
AND WHY IT ISN'T BEING DONE 

2415
02:05:29,880 --> 02:05:32,920
ALREADY AND IF IT IS, IT'S 

2416
02:05:32,920 --> 02:05:33,840
PROBABLY NOT SOMETHING ARPA-H 

2417
02:05:33,840 --> 02:05:38,920
WANTS TO VENTURE INTO.

2418
02:05:38,920 --> 02:05:44,520
>> THAT LEADS VERY WELL
INTO 

2419
02:05:44,520 --> 02:05:48,760
DAVID'S POINT.

2420
02:05:48,760 --> 02:05:50,600
>> LIKE THE OVER ALL
APPROACH 

2421
02:05:50,600 --> 02:05:52,840
AND LIKE TO SEE THE PROGRESS AND

2422
02:05:52,840 --> 02:05:54,760
THINKING WHAT WILL THIS 

2423
02:05:54,760 --> 02:05:55,600
CONCRETELY TURN INTO.

2424
02:05:55,600 --> 02:05:57,920
IT FEELS LIKE WE'RE AT THE 

2425
02:05:57,920 --> 02:06:00,080
ADJECTIVE LEVEL AND I WANT TO 

2426
02:06:00,080 --> 02:06:01,640
GET TO THE NOUN LEVEL.

2427
02:06:01,640 --> 02:06:05,240
I'M WONDERING WHAT YOUR THOUGHTS

2428
02:06:05,240 --> 02:06:09,880
ARE ON GETTING PROTOTYPICAL OR 

2429
02:06:09,880 --> 02:06:11,400
EMBLEMATIC OR ASPIRATIONAL.

2430
02:06:11,400 --> 02:06:13,520
HERE'S AN EXAMPLE OF THE KIND OF

2431
02:06:13,520 --> 02:06:13,720
PROGRAM.

2432
02:06:13,720 --> 02:06:16,280
THAT COULD BE IN THE FORM OF, 

2433
02:06:16,280 --> 02:06:19,800
HERE ARE TEN SETS OF ANSWERS TO 

2434
02:06:19,800 --> 02:06:23,800
THE QUESTIONS THAT MAY OR MAY 

2435
02:06:23,800 --> 02:06:24,760
NOT BE THE ACTUAL CORRECT 

2436
02:06:24,760 --> 02:06:27,280
SCIENCE BUT ARE THE CORRECT 

2437
02:06:27,280 --> 02:06:28,640
LEVEL TO ANTICIPATING THE 

2438
02:06:28,640 --> 02:06:32,200
QUESTION OF DYNAMIC AND 

2439
02:06:32,200 --> 02:06:32,600
TRANSFORMATIONAL.

2440
02:06:32,600 --> 02:06:33,480
WHAT'S THAT MEAN?

2441
02:06:33,480 --> 02:06:38,680
THIS IS NOT AN NIH THING, THIS 

2442
02:06:38,680 --> 02:06:41,280
IS AN ARPA-H THING.

2443
02:06:41,280 --> 02:06:42,360
WHAT ARE YOUR THOUGHTS HOW AND 

2444
02:06:42,360 --> 02:06:43,320
WHEN WE SHOULD MOVE?

2445
02:06:43,320 --> 02:06:53,760
>> THAT'S A GREAT
QUESTION.

2446
02:06:53,760 --> 02:06:56,280
>> IT NEEDS TO BE INFORMED
BY 

2447
02:06:56,280 --> 02:06:58,040
THE INAUGURAL DIRECTOR AND 

2448
02:06:58,040 --> 02:07:00,640
DEVELOP THEIR VISION FOR THE 

2449
02:07:00,640 --> 02:07:03,960
AGENCY.

2450
02:07:03,960 --> 02:07:05,960
I KNOW ADAM IS STARTING TO THINK

2451
02:07:05,960 --> 02:07:08,080
ABOUT THIS AND HAS THOUGHT ABOUT

2452
02:07:08,080 --> 02:07:10,840
THE TYPES OF EXAMPLES YOU'RE 

2453
02:07:10,840 --> 02:07:12,280
REQUESTING.

2454
02:07:12,280 --> 02:07:13,440
SINCE YOU'RE HERE YOU MIGHT AS 

2455
02:07:13,440 --> 02:07:18,600
WELL ELABORATE.

2456
02:07:18,600 --> 02:07:20,640
>> TO BE FAIR I DROPPED
FOR 30 

2457
02:07:20,640 --> 02:07:21,920
SECONDS AS A MOVING TARGET SO 

2458
02:07:21,920 --> 02:07:25,440
WHAT ARE WE GOING TO DO OR 

2459
02:07:25,440 --> 02:07:25,680
TOPICS?

2460
02:07:25,680 --> 02:07:30,440
>> AN CONCRETE EXAMPLES TO
HELP 

2461
02:07:30,440 --> 02:07:31,680
OTHERS KNOW WHAT PROPOSALS WE 

2462
02:07:31,680 --> 02:07:34,040
SHOULD BE MAKING THE RIGHT SHAPE

2463
02:07:34,040 --> 02:07:41,520
AND SIZE.

2464
02:07:41,520 --> 02:07:44,640
WHENEVER I TELL YOU A NEW 

2465
02:07:44,640 --> 02:07:46,560
DIRECTOR CAN COME IN AND SAY DID

2466
02:07:46,560 --> 02:07:49,320
YOU LISTEN TO THAT GUY WHICH IS 

2467
02:07:49,320 --> 02:07:49,560
FINE.

2468
02:07:49,560 --> 02:07:51,000
THE WAY THE ARPA-H STRUCTURE 

2469
02:07:51,000 --> 02:07:56,320
WORKS IS WE HAVE MISSION OFFICES

2470
02:07:56,320 --> 02:08:02,240
AND THEY'LL HAVE ROUGH AREAS OF 

2471
02:08:02,240 --> 02:08:10,600
RESPONSIBILITIES.

2472
02:08:10,600 --> 02:08:12,240
A PROGRAM MANAGER CAN COME IN 

2473
02:08:12,240 --> 02:08:13,640
WITH AN IDEA.

2474
02:08:13,640 --> 02:08:16,280
THERE'S EXCITEMENT WHAT TO DO 

2475
02:08:16,280 --> 02:08:18,480
WITH ELECTRONIC HEALTH RECORDS 

2476
02:08:18,480 --> 02:08:21,360
IF WE CAN FIX THE OPERABILITY 

2477
02:08:21,360 --> 02:08:22,240
PROBLEM.

2478
02:08:22,240 --> 02:08:24,000
I DON'T THINK THAT'S THE 

2479
02:08:24,000 --> 02:08:24,240
PROBLEM.

2480
02:08:24,240 --> 02:08:25,160
I SEE OTHER PROBLEMS THAT KEEP 

2481
02:08:25,160 --> 02:08:28,640
US FROM DOING WHAT WE WANT TO 

2482
02:08:28,640 --> 02:08:33,520
DO.

2483
02:08:33,520 --> 02:08:35,800
WHAT DRIVES ME NUTS IS THE 

2484
02:08:35,800 --> 02:08:37,080
SYSTEMS DON'T TALK TO EACH 

2485
02:08:37,080 --> 02:08:37,320
OTHER.

2486
02:08:37,320 --> 02:08:39,000
HERE'S MY CRAZY IDEA.

2487
02:08:39,000 --> 02:08:44,520
I THINK IF WE DO X WE CAN DO 

2488
02:08:44,520 --> 02:08:45,240
THAT.

2489
02:08:45,240 --> 02:08:47,680
INCLUDING LIMITATIONS AND WHY 

2490
02:08:47,680 --> 02:08:49,000
YOU THINK IT'S POSSIBLE AND THE 

2491
02:08:49,000 --> 02:08:50,200
ARPA-H DIRECTOR WILL SAY LET'S 

2492
02:08:50,200 --> 02:08:50,840
GO FOR IT.

2493
02:08:50,840 --> 02:08:53,520
HERE'S A BUNCH OF MONEY AND 

2494
02:08:53,520 --> 02:08:56,800
HERE'S THE MILESTONES AND WE 

2495
02:08:56,800 --> 02:09:00,640
WANT TO KNOW WHETHER YOUR CRAZY 

2496
02:09:00,640 --> 02:09:03,400
IDEA WILL PAN OUT.

2497
02:09:03,400 --> 02:09:04,320
I HAD THE QUESTION THIS MORNING 

2498
02:09:04,320 --> 02:09:05,960
DURING THE INTERVIEW OF TRYING 

2499
02:09:05,960 --> 02:09:08,720
NOT TO OVER FIXATE ON SPECIFIC 

2500
02:09:08,720 --> 02:09:09,120
DISEASES.

2501
02:09:09,120 --> 02:09:11,320
WE HEARD THAT FROM THE TALK 

2502
02:09:11,320 --> 02:09:11,600
SESSIONS.

2503
02:09:11,600 --> 02:09:12,400
IT'S IMPORTANT.

2504
02:09:12,400 --> 02:09:13,640
THINK ABOUT SUITE.

2505
02:09:13,640 --> 02:09:17,360
IF SOMEONE COMES IN AND HAS AN 

2506
02:09:17,360 --> 02:09:20,760
IDEA HOW TO RUN IN SUITE AND 

2507
02:09:20,760 --> 02:09:23,120
GIVEN THE COMORBIDITIES SLEEP IS

2508
02:09:23,120 --> 02:09:26,280
INVOLVED IN AND GIVE BACK GOOD 

2509
02:09:26,280 --> 02:09:29,040
BIOLOGICAL SLEEP IS SOMETHING WE

2510
02:09:29,040 --> 02:09:30,880
COULD PILE IN TO NOTING LOTS OF 

2511
02:09:30,880 --> 02:09:32,000
WORK ON SLEEP.

2512
02:09:32,000 --> 02:09:33,760
THE HARD WORK FOR THE MANAGER IS

2513
02:09:33,760 --> 02:09:35,480
TO POINT TO THE WORK DONE ON 

2514
02:09:35,480 --> 02:09:38,040
SLEEP AND FIND THE CRUX OF THE 

2515
02:09:38,040 --> 02:09:40,160
HARD PART WE CAN'T FIX NOW OR 

2516
02:09:40,160 --> 02:09:42,040
THE HARD PARTS AND ARPA-H CAN 

2517
02:09:42,040 --> 02:09:43,920
HAVE A RUN AT THAT.

2518
02:09:43,920 --> 02:09:44,800
WE MAY FAIL.

2519
02:09:44,800 --> 02:09:48,960
IT MAY BE TOO CRAZY TO WORK, BUT

2520
02:09:48,960 --> 02:09:50,960
IF IT WORKS IT WOULD BE VALUABLE

2521
02:09:50,960 --> 02:09:56,280
TO ALL THE FOLKS DOING THE HARD 

2522
02:09:56,280 --> 02:09:58,440
WORK THERE ALREADY.

2523
02:09:58,440 --> 02:10:00,080
SLEEP AND EARLY DIAGNOSIS OF 

2524
02:10:00,080 --> 02:10:02,600
DISEASE AND SOCIAL LEVEL I'M 

2525
02:10:02,600 --> 02:10:04,400
CONCERNED ABOUT THAT.

2526
02:10:04,400 --> 02:10:07,720
I SAW SOMETHING IN THE CHAT 

2527
02:10:07,720 --> 02:10:08,960
ABOUT MISINFORMATION.

2528
02:10:08,960 --> 02:10:11,240
DOES ARPA-H BELONG IN THAT SPACE

2529
02:10:11,240 --> 02:10:21,160
AND DEAL WITH MISINFORMATION?

2530
02:10:21,160 --> 02:10:24,640
WE LIVE SURROUNDED BY 

2531
02:10:24,640 --> 02:10:25,040
MISINFORMATION.

2532
02:10:25,040 --> 02:10:29,480
AND LEADING TO BAD  DECISIONS 

2533
02:10:29,480 --> 02:10:30,680
ABOUT HEALTH.

2534
02:10:30,680 --> 02:10:33,880
I SHOULD WE SHOULD ENTERTAIN 

2535
02:10:33,880 --> 02:10:35,360
THAT IDEA AND IF SOMEONE NEEDS 

2536
02:10:35,360 --> 02:10:36,760
AN APPROACH TO HELP ADDRESS SOME

2537
02:10:36,760 --> 02:10:38,520
OF THAT, GREAT.

2538
02:10:38,520 --> 02:10:40,640
SUPPLY CHAIN RESILIENCE IS A BIG

2539
02:10:40,640 --> 02:10:50,760
ISSUE.

2540
02:10:58,840 --> 02:11:01,520
OR DEALING WITH A MULTI-AGENT 

2541
02:11:01,520 --> 02:11:03,280
SYSTEM THAT ALLOW YOU TO COME UP

2542
02:11:03,280 --> 02:11:12,200
WITH SOLUTIONS FOR THE MISAL

2543
02:11:12,200 --> 02:11:13,520
MISALIMISAL

2544
02:11:13,520 --> 02:11:14,880
MISALIGNED COMPETITORS AND WE GO

2545
02:11:14,880 --> 02:11:17,600
THROUGH THE PROCESS AND NEED A 

2546
02:11:17,600 --> 02:11:18,440
PROGRAM MANAGER.

2547
02:11:18,440 --> 02:11:19,960
IF WE DON'T HAVE SOMEBODY THERE 

2548
02:11:19,960 --> 02:11:26,520
TO DRIVE, WE WON'T DO IT.

2549
02:11:26,520 --> 02:11:33,080
>> TO DAVID'S POINT, I
HAVEN'T 

2550
02:11:33,080 --> 02:11:38,040
HEARD ABOUT HEALTH EQUITY.

2551
02:11:38,040 --> 02:11:46,320
THIS MAY BE A QUESTION AND 

2552
02:11:46,320 --> 02:11:47,400
DAVID'S POINT ABOUT HAVE HEALTH 

2553
02:11:47,400 --> 02:11:49,600
EQUITY BE A PRIORITY AND YOU'RE 

2554
02:11:49,600 --> 02:11:52,880
THINKING AND FUTURE EMPLOYEES 

2555
02:11:52,880 --> 02:11:54,040
COME ON BOARD.

2556
02:11:54,040 --> 02:11:57,680
>> TARA, DO YOU WANT TO
TAKE 

2557
02:11:57,680 --> 02:11:57,880
THIS?

2558
02:11:57,880 --> 02:12:02,640
>> GO AHEAD.

2559
02:12:02,640 --> 02:12:09,000
I AGREE.

2560
02:12:09,000 --> 02:12:12,240
THE IDEA WOULD BE TO THINK ABOUT

2561
02:12:12,240 --> 02:12:17,120
IT IN A MULTI-PRONGED WAY 

2562
02:12:17,120 --> 02:12:19,040
BECAUSE WE NEED TO BRING IN 

2563
02:12:19,040 --> 02:12:21,600
PROGRAM MANAGERS AND OTHER STAFF

2564
02:12:21,600 --> 02:12:23,360
AND HAVE DIVERSE PERSPECTIVES TO

2565
02:12:23,360 --> 02:12:25,920
HELP THINK THROUGH AND IDENTIFY 

2566
02:12:25,920 --> 02:12:27,480
SOME OF THE CHALLENGES THAT WE 

2567
02:12:27,480 --> 02:12:30,360
MAY WANT TO TACKLE IN TERMS OF 

2568
02:12:30,360 --> 02:12:31,000
HEALTH EQUITY FOR A SPECIFIC 

2569
02:12:31,000 --> 02:12:36,600
PROGRAM.

2570
02:12:36,600 --> 02:12:39,320
ALSO AS YOU SAW IN THE REVIVED 

2571
02:12:39,320 --> 02:12:47,720
HEILMEIER QUESTIONS PROPOSED, 

2572
02:12:47,720 --> 02:12:48,680
HAVE QUESTIONS FOR HEALTH EQUITY

2573
02:12:48,680 --> 02:12:51,240
AND IT WILL BE APPLICABLE FOR 

2574
02:12:51,240 --> 02:12:52,640
EVERY PROGRAM THROUGH ARPA-H.

2575
02:12:52,640 --> 02:12:53,600
THERE HAS TO BE SOME 

2576
02:12:53,600 --> 02:12:55,040
CONSIDERATION GIVEN TO THAT FROM

2577
02:12:55,040 --> 02:12:56,240
THE BEGINNING EVERY PROGRAM TO 

2578
02:12:56,240 --> 02:12:59,400
HAVE PROGRAMS THAT HAVE A 

2579
02:12:59,400 --> 02:13:01,720
SPECIFIC FOCUS ON HEALTH EQUITY 

2580
02:13:01,720 --> 02:13:03,360
CHALLENGES BUT ALSO WANTING 

2581
02:13:03,360 --> 02:13:05,880
EVERY PROGRAM TO CONSIDER IT AS 

2582
02:13:05,880 --> 02:13:11,280
IT'S BEING DEVELOPED AND BUILT 

2583
02:13:11,280 --> 02:13:13,160
OUT AND THEN OF COURSE -- ADAM 

2584
02:13:13,160 --> 02:13:14,240
WERE YOU GOING TO GO.

2585
02:13:14,240 --> 02:13:15,640
>> NO, I'M JUST EXCITED.

2586
02:13:15,640 --> 02:13:17,800
IT'S THE BENEFIT OF BEING ABLE 

2587
02:13:17,800 --> 02:13:19,120
TO START FROM SCRATCH IN A WAY.

2588
02:13:19,120 --> 02:13:22,240
TWO THINGS TO ADD.

2589
02:13:22,240 --> 02:13:24,680
FIRST IS WE'RE COMMITTED TO 

2590
02:13:24,680 --> 02:13:25,560
METASCIENCE AND INTERESTED IN 

2591
02:13:25,560 --> 02:13:28,560
TRACKING AND STUDYING OURSELVES.

2592
02:13:28,560 --> 02:13:31,720
WE DO THAT TO IMPROVE THINGS.

2593
02:13:31,720 --> 02:13:32,680
DOES ARPA-H LOOK AMERICA?

2594
02:13:32,680 --> 02:13:43,000
THAT'S IMPORTANT.

2595
02:13:44,640 --> 02:13:47,640
AND DON'T BE SURPRISED IF IT 

2596
02:13:47,640 --> 02:13:49,840
ENDS UP LOOKING DIFFERENTLY TO 

2597
02:13:49,840 --> 02:13:52,680
GET PEOPLE IN ARPA-H.

2598
02:13:52,680 --> 02:13:57,280
THE CRITICAL FEATURE OF THE 

2599
02:13:57,280 --> 02:13:59,920
HEILMEIER QUESTION AND IF YOU 

2600
02:13:59,920 --> 02:14:00,960
CAN'T CREDIBLY ANSWER THE 

2601
02:14:00,960 --> 02:14:02,760
QUESTION, WE'RE NOT GOING TO 

2602
02:14:02,760 --> 02:14:03,000
LAUNCH.

2603
02:14:03,000 --> 02:14:07,680
IT'S NOT WINDOW DRESSING IF YOU 

2604
02:14:07,680 --> 02:14:09,760
CAN'T ENSURE THE RESULTS ARE 

2605
02:14:09,760 --> 02:14:11,560
EQUITABLE, YOU'RE NOT GETTING 

2606
02:14:11,560 --> 02:14:11,760
MONEY.

2607
02:14:11,760 --> 02:14:12,800
THAT'S HOW IMPORTANT THAT IS.

2608
02:14:12,800 --> 02:14:23,280
THAT'S WHY IT'S A BIG DEAL.

2609
02:14:34,960 --> 02:14:36,680
>> DID YOU WANT TO WEIGH
IN?

2610
02:14:36,680 --> 02:14:37,920
>> WHAT KIND OF
INSTITUTIONS 

2611
02:14:37,920 --> 02:14:39,480
WILL APPLY FOR ARPA-H?

2612
02:14:39,480 --> 02:14:43,400
YOU THINK OF THOSE THAT APPLY 

2613
02:14:43,400 --> 02:14:47,200
FOR ARPA AND DARPA YOU SEE THE 

2614
02:14:47,200 --> 02:14:52,280
TRADITIONAL NIH APPLICANTS ALSO 

2615
02:14:52,280 --> 02:15:00,120
PLAYING A ROLE HERE.

2616
02:15:00,120 --> 02:15:02,280
>> WE HAVE PERFORMERS
COMING 

2617
02:15:02,280 --> 02:15:06,560
FROM A VARIETY OF AREAS AND 

2618
02:15:06,560 --> 02:15:07,440
SEGMENTS OF THE COMMUNITY.

2619
02:15:07,440 --> 02:15:10,840
FROM ACADEMIC RESEARCHERS TO 

2620
02:15:10,840 --> 02:15:13,000
COMPANIES TO SMALL BUSINESSES.

2621
02:15:13,000 --> 02:15:16,080
AND EVERYTHING AND EVERYONE IN 

2622
02:15:16,080 --> 02:15:18,120
BETWEEN.

2623
02:15:18,120 --> 02:15:21,200
IDEALLY WE'RE GOING TO BE 

2624
02:15:21,200 --> 02:15:24,440
PROMOTING THESE LARGE-SCALE 

2625
02:15:24,440 --> 02:15:26,360
CHALLENGES THAT WILL PROBABLY 

2626
02:15:26,360 --> 02:15:28,640
NECESSITATE 

2627
02:15:28,640 --> 02:15:29,880
INTERDISCIPLINARY-TRANS 

2628
02:15:29,880 --> 02:15:30,880
DISCIPLINARY APPROACHES.

2629
02:15:30,880 --> 02:15:32,440
HOPING PEOPLE WILL COME TOGETHER

2630
02:15:32,440 --> 02:15:35,480
AND FORM TEAMS THAT ARE NOT THE 

2631
02:15:35,480 --> 02:15:39,200
TYPICAL TEAMS WE'D PUT TOGETHER 

2632
02:15:39,200 --> 02:15:40,320
NECESSARILY.

2633
02:15:40,320 --> 02:15:41,000
WE'LL TRY TO ENCOURAGE THAT 

2634
02:15:41,000 --> 02:15:46,080
FORMATION.

2635
02:15:46,080 --> 02:15:49,040
>> I WAS IN THE DEFENSE
SCIENCES

2636
02:15:49,040 --> 02:15:49,680
OFFICE.

2637
02:15:49,680 --> 02:15:53,000
DARPA HAS SIX DIFFERENT OFFICES.

2638
02:15:53,000 --> 02:15:56,960
DEPENDING ON THE LEVEL OF 

2639
02:15:56,960 --> 02:15:58,080
MATURITY OF THE PROBLEM OR 

2640
02:15:58,080 --> 02:15:59,360
SOLUTION YOU'RE FOCUSSED ON, 

2641
02:15:59,360 --> 02:16:02,720
YOU'LL GET A RANGE OF PEOPLE.

2642
02:16:02,720 --> 02:16:05,400
AT DSO WERE FOLKS AT FUNDAMENTAL

2643
02:16:05,400 --> 02:16:08,360
RESEARCH AND TRYING TO DEVELOP 

2644
02:16:08,360 --> 02:16:10,240
NEW MECHANISMS TO PRODUCE 

2645
02:16:10,240 --> 02:16:10,520
RESEARCH.

2646
02:16:10,520 --> 02:16:12,520
WE HAD TONS OF UNIVERSITIES BUT 

2647
02:16:12,520 --> 02:16:14,360
ALSO UNIVERSITIES WORKING WITH 

2648
02:16:14,360 --> 02:16:15,800
SMALL COMPANIES WHO HAVE SINCE 

2649
02:16:15,800 --> 02:16:19,080
GONE ON TO TRY TO COMMERCIALIZE 

2650
02:16:19,080 --> 02:16:22,480
THE ALGORITHMS.

2651
02:16:22,480 --> 02:16:24,200
IF WE DO THIS RIGHT THE BEST 

2652
02:16:24,200 --> 02:16:24,800
IDEAS WILL COME FROM DIVERSE 

2653
02:16:24,800 --> 02:16:34,920
GROUPS.

2654
02:16:43,120 --> 02:16:45,560
>> IS THERE THINKING IT'S 

2655
02:16:45,560 --> 02:16:47,240
SHORT-TERM, GIVE IT YOUR ALL AND

2656
02:16:47,240 --> 02:16:48,480
THEN SOMEONE ELSE COMES IN?

2657
02:16:48,480 --> 02:16:59,000
>> WE'RE THINKING LONGER
TERM.

2658
02:17:02,200 --> 02:17:03,840
FOR ARPA-H THE IDEA WE'RE 

2659
02:17:03,840 --> 02:17:05,480
THINKING ABOUT HERE IS DOING 

2660
02:17:05,480 --> 02:17:11,120
THREE-YEAR TERMS RENEWABLE ONE 

2661
02:17:11,120 --> 02:17:13,680
TIME.

2662
02:17:13,680 --> 02:17:16,280
THERE CAN BE TURNOVER IN THE 

2663
02:17:16,280 --> 02:17:19,680
PEOPLE COMING ON BOARD IN THE 

2664
02:17:19,680 --> 02:17:21,920
PROGRAM MANAGER ROLE.

2665
02:17:21,920 --> 02:17:24,680
THEY'LL LAUNCH A PROGRAM OR TWO 

2666
02:17:24,680 --> 02:17:26,160
OR THREE IN THEIR TENURE AND 

2667
02:17:26,160 --> 02:17:28,680
WILL LIKELY NOT SEE IT RUN THE 

2668
02:17:28,680 --> 02:17:30,160
ENTIRE DURATION THEY ARE THERE.

2669
02:17:30,160 --> 02:17:32,520
SOMEONE ELSE WILL COME IN AND BE

2670
02:17:32,520 --> 02:17:35,400
ABLE TO TAKE OVER THEIR PROGRAM 

2671
02:17:35,400 --> 02:17:36,600
AND I THINK THERE'S A LOT OF 

2672
02:17:36,600 --> 02:17:39,800
VALUE IN THAT BECAUSE YOU'RE 

2673
02:17:39,800 --> 02:17:40,760
BRINGING IN A NEW PERSPECTIVE 

2674
02:17:40,760 --> 02:17:43,000
AND IT MIGHT BE SUCH THAT THE 

2675
02:17:43,000 --> 02:17:44,680
PROGRAM HAS EVOLVED AND CHANGED 

2676
02:17:44,680 --> 02:17:46,880
IN THE TYPE OF EXPERTISE AND 

2677
02:17:46,880 --> 02:17:48,120
PROGRAM MANAGER THAT WOULD BE 

2678
02:17:48,120 --> 02:17:48,480
NEEDED.

2679
02:17:48,480 --> 02:17:50,360
IT WOULD BE DIFFERENT IN YOUR 

2680
02:17:50,360 --> 02:17:55,120
THREE  -- IN YEAR THREE THAN 

2681
02:17:55,120 --> 02:18:05,200
ONE.

2682
02:18:10,360 --> 02:18:12,560
>> EXECUTION WILL BE MORE
STAFF 

2683
02:18:12,560 --> 02:18:19,080
DRIVEN OR NEW STAFF COME IN FOR 

2684
02:18:19,080 --> 02:18:21,560
THAT.

2685
02:18:21,560 --> 02:18:24,720
>> DO YOU SEE DOLLARS FOR 

2686
02:18:24,720 --> 02:18:25,520
TRANSLATIONAL RESEARCH MOVING 

2687
02:18:25,520 --> 02:18:28,680
TOWARDS ARPA-H AWAY FROM THE 

2688
02:18:28,680 --> 02:18:34,560
REST OF NIH LET'S SAY?

2689
02:18:34,560 --> 02:18:44,640
.

2690
02:19:10,840 --> 02:19:13,120
>> THEY WERE HANDING ME
STUFF TO

2691
02:19:13,120 --> 02:19:23,280
RUN WITH BECAUSE IT WAS MORE 

2692
02:19:23,280 --> 02:19:25,560
LIKE HOLDING DOLLARS.

2693
02:19:25,560 --> 02:19:27,280
>> THE IDEA IS TO SHOP 

2694
02:19:27,280 --> 02:19:29,600
THEMSELVES TO THE APPROPRIATE 

2695
02:19:29,600 --> 02:19:31,640
VENUE FROM A LARGER CONSTITUENCY

2696
02:19:31,640 --> 02:19:32,600
OF APPLICANTS.

2697
02:19:32,600 --> 02:19:33,920
FINAL QUESTION AND I'LL TURN IT 

2698
02:19:33,920 --> 02:19:38,600
OVER TO OTHERS.

2699
02:19:38,600 --> 02:19:42,240
IF YOU CAN USE PHRASES LIKE 

2700
02:19:42,240 --> 02:19:48,600
DYNAMIC AND TRANSFORMATIONAL 

2701
02:19:48,600 --> 02:19:54,720
WITH ARPA-H FUNDS WHY CAN'T WE 

2702
02:19:54,720 --> 02:19:56,480
USE THEM AT NIH?

2703
02:19:56,480 --> 02:19:58,280
>> YOU STARTED TO SAY WHAT
I WAS

2704
02:19:58,280 --> 02:19:59,280
GOING SAY.

2705
02:19:59,280 --> 02:20:00,840
>> THEY'RE NOT MUTUALLY 

2706
02:20:00,840 --> 02:20:03,000
EXCLUSIVE AND THERE'S BEEN GOOD 

2707
02:20:03,000 --> 02:20:04,120
EXAMPLES IN RESPONSE TO THE 

2708
02:20:04,120 --> 02:20:05,080
PANDEMIC IN PARTICULAR WHERE I 

2709
02:20:05,080 --> 02:20:11,240
THINK YOU CAN ILLUSTRATE HOW NIH

2710
02:20:11,240 --> 02:20:13,040
HAS BEEN AND IT'S BEEN DYNAMIC 

2711
02:20:13,040 --> 02:20:14,960
AND TRANSFORMATIONAL AND 

2712
02:20:14,960 --> 02:20:16,800
THINKING ABOUT THE ACTIVE 

2713
02:20:16,800 --> 02:20:19,120
PARTNERSHIP WE HAVE RADX AND THE

2714
02:20:19,120 --> 02:20:25,920
LIST GOES ON AND ON.

2715
02:20:25,920 --> 02:20:27,720
AND A DIFFERENCE IN APPROACH IN 

2716
02:20:27,720 --> 02:20:28,640
HOW WE'RE SUPPORTING RESEARCH 

2717
02:20:28,640 --> 02:20:31,080
AND THINKING ABOUT THAT 

2718
02:20:31,080 --> 02:20:31,360
APPROACH.

2719
02:20:31,360 --> 02:20:33,520
THAT'S ONE OF THE THINGS.

2720
02:20:33,520 --> 02:20:39,320
AGAIN, WE HOPE THIS IS A VERY 

2721
02:20:39,320 --> 02:20:40,200
SYNERGISTIC AND COLLABORATIVE 

2722
02:20:40,200 --> 02:20:42,320
EFFORT THAT HAPPENS BETWEEN 

2723
02:20:42,320 --> 02:20:43,400
ARPA-H AND NIH.

2724
02:20:43,400 --> 02:20:48,960
LARRY, DID YOU WANT TO -- 

2725
02:20:48,960 --> 02:20:51,280
>> AGAIN, I DON'T THINK I
NEED 

2726
02:20:51,280 --> 02:20:52,720
TO REMIND THIS GROUP BUT WILL 

2727
02:20:52,720 --> 02:20:55,120
FOR COMPLETENESS, THE ADVANCES 

2728
02:20:55,120 --> 02:20:57,440
THAT WERE MADE DURING THE 

2729
02:20:57,440 --> 02:20:58,440
PANDEMIC WERE BUILT UPON MANY 

2730
02:20:58,440 --> 02:21:04,640
YEARS OF BASIC RESEARCH.

2731
02:21:04,640 --> 02:21:07,520
NIH HAS CONTINUED TO FUND THE 

2732
02:21:07,520 --> 02:21:08,480
FUNDAMENTAL WORK.

2733
02:21:08,480 --> 02:21:12,640
WITHOUT IT, YOU'RE NOT GOING TO 

2734
02:21:12,640 --> 02:21:14,040
SEE THE BREAKTHROUGHS.

2735
02:21:14,040 --> 02:21:16,360
IN A SENSE WE GOT FORTUNATE 

2736
02:21:16,360 --> 02:21:20,000
BECAUSE THE PANDEMIC WAS A VIRUS

2737
02:21:20,000 --> 02:21:22,760
WE ALREADY KNEW QUITE A BIT 

2738
02:21:22,760 --> 02:21:23,080
ABOUT.

2739
02:21:23,080 --> 02:21:26,040
HAD IT BEEN A VIRUS WE DID KNOW 

2740
02:21:26,040 --> 02:21:31,240
A BIT ABOUT THE RESULTS WOULD 

2741
02:21:31,240 --> 02:21:39,600
NOT HAVE BEEN AS POSITIVE.

2742
02:21:39,600 --> 02:21:47,600
>>  I THINK TO THE POINT
OF 

2743
02:21:47,600 --> 02:21:51,960
USING TERMS LIKE DYNAMIC AND 

2744
02:21:51,960 --> 02:21:52,360
TRANSFORMATIONAL.

2745
02:21:52,360 --> 02:21:53,960
EVERY PROGRAM WILL GO THROUGH 

2746
02:21:53,960 --> 02:21:57,720
WHAT WE CALL DARPA TECH COUNCIL 

2747
02:21:57,720 --> 02:21:59,800
AND HERE CALLED SCIENTIFIC TECH 

2748
02:21:59,800 --> 02:22:01,520
COUNCIL IF YOU WANT TO GET 

2749
02:22:01,520 --> 02:22:03,840
MURDERED TALK ABOUT YOUR PROGRAM

2750
02:22:03,840 --> 02:22:05,040
IS DYNAMIC AND DON'T HAVE 

2751
02:22:05,040 --> 02:22:06,440
METRICS AND SEE HOW FAST YOU'RE 

2752
02:22:06,440 --> 02:22:08,480
SENT BACK TO THE FLOOR.

2753
02:22:08,480 --> 02:22:10,760
I THINK WE'LL BAN WORDS LIKE 

2754
02:22:10,760 --> 02:22:11,880
DYNAMIC AND INNOVATION.

2755
02:22:11,880 --> 02:22:13,680
IT MEANS SO YOU'RE CHANGING 

2756
02:22:13,680 --> 02:22:14,760
PERFORMERS EVERY SIX MONTHS.

2757
02:22:14,760 --> 02:22:15,920
I CAN UNDERSTAND THAT.

2758
02:22:15,920 --> 02:22:17,840
YOU DON'T NEED THE WORD DYNAMIC 

2759
02:22:17,840 --> 02:22:18,360
FOR THAT.

2760
02:22:18,360 --> 02:22:22,200
TO YOUR POINT, WE CAN TALK ABOUT

2761
02:22:22,200 --> 02:22:23,920
IT ALL WE WANT BUT IT COMES DOWN

2762
02:22:23,920 --> 02:22:26,400
TO METRICS AND PEOPLE WHO TRY TO

2763
02:22:26,400 --> 02:22:28,200
GET AWAY WITH IT'S A DYNAMIC 

2764
02:22:28,200 --> 02:22:29,960
PROGRAM AND DON'T HAVE METRICS 

2765
02:22:29,960 --> 02:22:30,640
IT WON'T BE A GOOD PLACE FOR 

2766
02:22:30,640 --> 02:22:40,000
THEM.

2767
02:22:40,000 --> 02:22:42,240
THERE GOING TO BE OPPORTUNITIES 

2768
02:22:42,240 --> 02:22:44,600
FOR BACKGROUND AROUND THE IDEA 

2769
02:22:44,600 --> 02:22:47,040
OF SUPPORT AND RESEARCH.

2770
02:22:47,040 --> 02:22:50,720
THERE MAY BE NEW APPROACHES TO 

2771
02:22:50,720 --> 02:22:54,280
MAKING AWARDS THAT ARPA-H MIGHT 

2772
02:22:54,280 --> 02:22:57,120
PIONEER AND NIH MAY BE ABLE TO 

2773
02:22:57,120 --> 02:22:59,040
ADOPT WITH AUTHORITIES THAT 

2774
02:22:59,040 --> 02:22:59,240
EXIST.

2775
02:22:59,240 --> 02:23:02,760
WE ARE HOPING TO REALLY HAVE IT 

2776
02:23:02,760 --> 02:23:11,520
BE A LEARNING PROCESS OVER ALL.

2777
02:23:11,520 --> 02:23:12,640
I CAN'T TELL THE ORDER OF THE 

2778
02:23:12,640 --> 02:23:17,880
QUESTIONS.

2779
02:23:17,880 --> 02:23:18,880
>> I THINK SHELLY HAD THE
NEXT 

2780
02:23:18,880 --> 02:23:24,760
QUESTION.

2781
02:23:24,760 --> 02:23:27,600
I WANTED TO POINT OUT THE 

2782
02:23:27,600 --> 02:23:29,400
STABILITY OF RNA FOR THE 

2783
02:23:29,400 --> 02:23:34,760
VACCINES WAS ABSOLUTELY CRUCIAL 

2784
02:23:34,760 --> 02:23:45,320
TO WHERE WE ARE NOW RETURNING TO

2785
02:23:48,520 --> 02:23:52,640
NORMAL FROM RESEARCH DONE A LONG

2786
02:23:52,640 --> 02:24:02,800
TIME AGO.

2787
02:24:13,800 --> 02:24:15,400
 WE WERE TALKING ABOUT TOPICS 

2788
02:24:15,400 --> 02:24:19,880
AND IT'S AMAZING THE 

2789
02:24:19,880 --> 02:24:22,960
TECHNOLOGICAL BREAKTHROUGH AND I

2790
02:24:22,960 --> 02:24:26,880
DIDN'T DEMAND AS THE BOTTLENECK 

2791
02:24:26,880 --> 02:24:30,040
AND HE THINKS ARPA-H CAN GET 

2792
02:24:30,040 --> 02:24:31,800
INTO THE BRINGING THE SOCIO 

2793
02:24:31,800 --> 02:24:36,640
ECONOMIC STUFF TO THE MODELS TO 

2794
02:24:36,640 --> 02:24:43,080
ANTICIPATE THIS SO GOOD POINT.

2795
02:24:43,080 --> 02:24:44,920
>> ARE THEY TAKING ON
RESEARCH 

2796
02:24:44,920 --> 02:24:55,320
RELATED TO GUN VIOLENCE.

2797
02:25:12,520 --> 02:25:14,360
>> IT HAS TO ANSWER THE 

2798
02:25:14,360 --> 02:25:15,240
HEILMEIER QUESTION AND FIT THE 

2799
02:25:15,240 --> 02:25:16,600
VISION FOR THE ORGANIZATION.

2800
02:25:16,600 --> 02:25:18,400
>> IS THERE A
TRANSFORMATIVE WAY

2801
02:25:18,400 --> 02:25:20,600
TO GO AFTER THE BEHAVIORAL 

2802
02:25:20,600 --> 02:25:23,520
ASPECTS THAT LEAD PEOPLE TO 

2803
02:25:23,520 --> 02:25:24,520
EITHER COMMIT GUN VIOLENCE OR 

2804
02:25:24,520 --> 02:25:28,520
THE FEAR THAT CAUSES HIGH-LEVELS

2805
02:25:28,520 --> 02:25:31,520
OF GUN OWNERSHIP, THAT KIND OF 

2806
02:25:31,520 --> 02:25:32,000
THING.

2807
02:25:32,000 --> 02:25:33,640
I REALIZE NIH AND OTHER AGENCIES

2808
02:25:33,640 --> 02:25:36,640
CAN'T DO THINGS THAT ARE ABOUT 

2809
02:25:36,640 --> 02:25:39,800
THE POLICY BUT THE UNDERLYING 

2810
02:25:39,800 --> 02:25:41,760
EPIDEMIOLOGY AND BIOLOGY OF 

2811
02:25:41,760 --> 02:25:45,960
HUMAN BEHAVIOR SURELY IS.

2812
02:25:45,960 --> 02:25:48,960
TAGGING ON TO SHELLY'S POINT I 

2813
02:25:48,960 --> 02:25:50,200
THINK IT'S INTERESTING IN THE 

2814
02:25:50,200 --> 02:25:55,320
HISTORY OF THE RNA VACCINES 

2815
02:25:55,320 --> 02:25:57,320
DARPA HAD A ROLE TO PLAY IN THE 

2816
02:25:57,320 --> 02:25:58,160
BACKGROUND WORK.

2817
02:25:58,160 --> 02:25:59,640
IT'S A CLASSIC CASE WHERE BOTH 

2818
02:25:59,640 --> 02:26:00,760
HAD TO PUSH FROM DIFFERENT 

2819
02:26:00,760 --> 02:26:01,040
DIRECTIONS.

2820
02:26:01,040 --> 02:26:03,080
>> CORRECT.

2821
02:26:03,080 --> 02:26:12,360
>> IT'S AN ECO SYSTEM.

2822
02:26:12,360 --> 02:26:14,200
>> DAVID, DID YOU HAVE A 

2823
02:26:14,200 --> 02:26:14,600
FOLLOW-UP?

2824
02:26:14,600 --> 02:26:16,640
>> IT WAS COVERED, THANKS.

2825
02:26:16,640 --> 02:26:25,720
>> THANK YOU.

2826
02:26:25,720 --> 02:26:26,040
DINA.

2827
02:26:26,040 --> 02:26:28,040
>> I'M WONDERING IF YOU
LOOK AT 

2828
02:26:28,040 --> 02:26:31,000
NIH TRADITIONALLY THE 

2829
02:26:31,000 --> 02:26:33,720
INVESTMENTS AT NIH ARE VERY MUCH

2830
02:26:33,720 --> 02:26:35,680
CORE IN BIOLOGY, BIO MEDICINE 

2831
02:26:35,680 --> 02:26:36,440
AND MEDICINE.

2832
02:26:36,440 --> 02:26:39,280
I'M WONDERING WHAT IS THE VISION

2833
02:26:39,280 --> 02:26:45,920
IF ARPA-H WITH RESPECT TO 

2834
02:26:45,920 --> 02:26:47,920
MACHINE LEARNING AND COMPUTER 

2835
02:26:47,920 --> 02:26:49,120
SCIENTIST AND MACHINE LEARNING 

2836
02:26:49,120 --> 02:26:51,600
EXPERTS PART OF THIS OR KNOW THE

2837
02:26:51,600 --> 02:26:53,120
FOCUS IS IN A DIFFERENT 

2838
02:26:53,120 --> 02:26:53,360
DIRECTION?

2839
02:26:53,360 --> 02:26:59,640
>> THEY'RE ABSOLUTELY PART
OF 

2840
02:26:59,640 --> 02:27:00,120
IT.

2841
02:27:00,120 --> 02:27:04,720
IT HAS TO COME WITH THE WELL 

2842
02:27:04,720 --> 02:27:06,160
DEFINED QUESTION AND HELPING 

2843
02:27:06,160 --> 02:27:10,120
DESIGN PROGRAMS THAT MAY BE MOST

2844
02:27:10,120 --> 02:27:14,720
RELEVANT BUT YOU CAN IMAGINE A 

2845
02:27:14,720 --> 02:27:16,920
BROAD USE OF COMPUTER SCIENCE 

2846
02:27:16,920 --> 02:27:18,720
AND DATA SCIENCE AS PART OF MANY

2847
02:27:18,720 --> 02:27:19,920
DIFFERENT TYPES OF QUESTIONS 

2848
02:27:19,920 --> 02:27:27,880
THAT ARPA-H MAY WANT TO TACKLE.

2849
02:27:27,880 --> 02:27:29,400
>> DO YOU ENVISION THE
PROGRAM 

2850
02:27:29,400 --> 02:27:30,360
MANAGEMENT WOULD BE FOCUSSED IN 

2851
02:27:30,360 --> 02:27:35,960
THOSE AREAS?

2852
02:27:35,960 --> 02:27:37,680
>> POTENTIALLY.

2853
02:27:37,680 --> 02:27:39,120
WE NEED THE INAUGURAL DIRECTOR 

2854
02:27:39,120 --> 02:27:40,640
TO OUTLINE THE VISION.

2855
02:27:40,640 --> 02:27:43,280
I APOLOGIZE FOR BEING A LITTLE 

2856
02:27:43,280 --> 02:27:45,680
BIT OF A BROKEN RECORD THERE BUT

2857
02:27:45,680 --> 02:27:48,280
THEY NEED TO DEFINE WHAT THEIR 

2858
02:27:48,280 --> 02:27:50,280
VISION IS FOR ARPA-H.

2859
02:27:50,280 --> 02:27:54,440
I WOULD IMAGINE THAT THERE WILL 

2860
02:27:54,440 --> 02:27:55,920
BE SOME ELEMENT OR PROGRAM 

2861
02:27:55,920 --> 02:27:58,000
THAT'S RELATED TO THIS.

2862
02:27:58,000 --> 02:28:01,320
>> LET ME PRE-REGISTER THE

2863
02:28:01,320 --> 02:28:07,520
HYPOTHESIS NOW I'D BE SURPRISED 

2864
02:28:07,520 --> 02:28:18,080
GIVEN THE EXPERTS AND VISIONARY 

2865
02:28:19,160 --> 02:28:19,280
FOCUS.

2866
02:28:19,280 --> 02:28:20,360
I'D BE SURPRISED IF WE'RE NOT 

2867
02:28:20,360 --> 02:28:20,560
THERE.

2868
02:28:20,560 --> 02:28:25,760
>> I WANT TO ADD ONE THING
WHICH

2869
02:28:25,760 --> 02:28:27,640
IS THAT I HAVE NO DOUBT THERE'S 

2870
02:28:27,640 --> 02:28:31,400
A HUGE AMOUNT OF INTEREST IN THE

2871
02:28:31,400 --> 02:28:38,880
POTENTIAL AND PROCEDURE AND WHAT

2872
02:28:38,880 --> 02:28:40,400
KIND FUTURE THERE IS ON THESE 

2873
02:28:40,400 --> 02:28:45,440
KINDS OF ISSUES.

2874
02:28:45,440 --> 02:28:47,120
>> OTHER COMMENTS OR
QUESTIONS 

2875
02:28:47,120 --> 02:28:55,280
ABOUT ARPA-H?

2876
02:28:55,280 --> 02:28:57,920
>> I'LL ONE I KNOW YOU
WON'T BE 

2877
02:28:57,920 --> 02:29:00,560
ABLE TO ANSWER BUT JUST IN CASE.

2878
02:29:00,560 --> 02:29:01,680
TIMING FOR A DIRECTOR TO BE 

2879
02:29:01,680 --> 02:29:05,960
NOMINATE AND GET YOU OFF YOUR 

2880
02:29:05,960 --> 02:29:07,120
BROKEN RECORD.

2881
02:29:07,120 --> 02:29:13,480
>> UNCLEAR.

2882
02:29:13,480 --> 02:29:20,440
AGAIN, IT'S A PRESS  -- 

2883
02:29:20,440 --> 02:29:25,840
PRESIDENTIAL APPOINTEE.

2884
02:29:25,840 --> 02:29:28,640
IT'S NOT AS ROBUST A PROCESS SO 

2885
02:29:28,640 --> 02:29:34,280
IT CAN MOVE QUICKER.

2886
02:29:34,280 --> 02:29:35,960
WE'RE OPTIMISTIC IT'S A PRIORITY

2887
02:29:35,960 --> 02:29:38,200
FOR THE ADMINISTRATION.

2888
02:29:38,200 --> 02:29:39,440
HOPEFULLY WE'LL SEE ONE IN THE 

2889
02:29:39,440 --> 02:29:40,600
NEAR FUTURE.

2890
02:29:40,600 --> 02:29:44,000
>> WE KNOW THIS IS A HIGH 

2891
02:29:44,000 --> 02:29:44,520
PRIORITY.

2892
02:29:44,520 --> 02:29:46,120
IT IS MOVING FORWARD.

2893
02:29:46,120 --> 02:29:47,720
AGAIN, IT'S A PRESIDENTIAL 

2894
02:29:47,720 --> 02:29:49,480
APPOINTMENT AND OBVIOUSLY 

2895
02:29:49,480 --> 02:29:52,920
THERE'S STEPS THEY TAKE AT THE 

2896
02:29:52,920 --> 02:29:56,720
WHITE HOUSE WE'RE NOT PRIVY TO.

2897
02:29:56,720 --> 02:30:00,840
WE'RE HOPEFUL THIS WILL MOVE 

2898
02:30:00,840 --> 02:30:01,520
FORWARD.

2899
02:30:01,520 --> 02:30:03,440
>> I'M PRETTY SURE THEY
PUT ME 

2900
02:30:03,440 --> 02:30:05,560
IN THIS POSITION TO SPEED THINGS

2901
02:30:05,560 --> 02:30:08,400
UP BECAUSE THEY'RE LIKE MY GOD 

2902
02:30:08,400 --> 02:30:10,360
LOOK WHAT THEY'RE DOING IN 

2903
02:30:10,360 --> 02:30:12,600
ABSENCE OF A DIRECTOR.

2904
02:30:12,600 --> 02:30:19,800
>> ADAM, WE SHARE THAT
ROLE, AS 

2905
02:30:19,800 --> 02:30:23,240
YOU KNOW, AND I THINK MAYBE 

2906
02:30:23,240 --> 02:30:25,840
WE'LL BE REALLY EFFECTIVE.

2907
02:30:25,840 --> 02:30:27,120
WE'LL SEE.

2908
02:30:27,120 --> 02:30:28,600
IT'S A TREMENDOUS OPPORTUNITY 

2909
02:30:28,600 --> 02:30:37,520
FOR THE RIGHT PERSON.

2910
02:30:37,520 --> 02:30:39,200
WE LOOK FORWARD TO WELCOMING THE

2911
02:30:39,200 --> 02:30:46,440
INAUGURAL DIRECTOR.

2912
02:30:46,440 --> 02:30:49,200
BARBARA YOU BRING UP SO-CALLED 

2913
02:30:49,200 --> 02:30:50,720
PROVOCATIVE QUESTIONS FROM NCI.

2914
02:30:50,720 --> 02:30:52,840
MAYBE YOU CAN ELABORATE.

2915
02:30:52,840 --> 02:30:54,640
>> I MAY NOT BE THE BEST
PERSON 

2916
02:30:54,640 --> 02:30:58,640
TO DO IT BUT I HAD SOME 

2917
02:30:58,640 --> 02:31:02,480
FAMILIARITY WITH IT A DECADE 

2918
02:31:02,480 --> 02:31:04,480
AGO.

2919
02:31:04,480 --> 02:31:06,880
NCI'S HAD A CUSTOM OF PUTTING UP

2920
02:31:06,880 --> 02:31:10,400
A SET OF PROVOCATIVE QUESTIONS 

2921
02:31:10,400 --> 02:31:13,240
FOR PEOPLE TO SHOOT AT AND 

2922
02:31:13,240 --> 02:31:16,400
POTENTIALLY WRITE GRANTS AND 

2923
02:31:16,400 --> 02:31:19,360
RESPECT TO ARPA-H AND A LITTLE 

2924
02:31:19,360 --> 02:31:24,120
BIT OF CROWD SOURCING ABOUT 

2925
02:31:24,120 --> 02:31:26,560
PROVOCATIVE QUESTIONS MAY BE AN 

2926
02:31:26,560 --> 02:31:27,360
INTERESTING BIN FOR FOCUS.

2927
02:31:27,360 --> 02:31:29,400
THESE ARE THE KINDS OF THINGS 

2928
02:31:29,400 --> 02:31:32,480
THAT ARE NOT THE USUAL LINES OF 

2929
02:31:32,480 --> 02:31:32,840
RESEARCH.

2930
02:31:32,840 --> 02:31:35,160
I REMEMBER ONE P.Q. ABOUT CANCER

2931
02:31:35,160 --> 02:31:40,120
SO SIMPLE AND YET SO DIFFICULT.

2932
02:31:40,120 --> 02:31:50,640
WHY DO PATIENTS ACTUALLY DIE.

2933
02:31:52,560 --> 02:31:54,640
IT'S NOT SO SIMPLE AND THERE WAS

2934
02:31:54,640 --> 02:31:59,200
A HOST OF FOCI.

2935
02:31:59,200 --> 02:32:02,640
>> MIKE LAUER PUT A LINK
TO THE 

2936
02:32:02,640 --> 02:32:03,680
PROVOCATIVE QUESTIONS.

2937
02:32:03,680 --> 02:32:04,960
>> YOU CAN GET CURRENT
ONES.

2938
02:32:04,960 --> 02:32:14,800
>> OTHER COMMENTS OR
QUESTIONS?

2939
02:32:14,800 --> 02:32:17,120
>> I KNOW YOU PROBABLY
HAVE 

2940
02:32:17,120 --> 02:32:19,000
INSIGHT INTO THE QUESTION ABOUT 

2941
02:32:19,000 --> 02:32:29,240
THE STIMULUS.

2942
02:32:32,600 --> 02:32:35,160
>> THE RECOVERY ACT
STIMULUS.

2943
02:32:35,160 --> 02:32:36,760
THERE WAS A LONG LIST OF THINGS 

2944
02:32:36,760 --> 02:32:47,160
SUPPORTED DURING THAT TIME.

2945
02:32:47,160 --> 02:32:48,280
SOME WORK TOOK HOLD AND 

2946
02:32:48,280 --> 02:32:50,000
CONTINUES TO THIS DAY AND OTHER 

2947
02:32:50,000 --> 02:32:54,400
THINGS THAT WAS A GREAT IDEAS 

2948
02:32:54,400 --> 02:32:55,320
DIDN'T PAN OUT.

2949
02:32:55,320 --> 02:32:58,000
THE BEAUTY OF THE RECOVERY ACT 

2950
02:32:58,000 --> 02:33:04,080
IT ALLOWED SO MANY NEW IDEAS TO 

2951
02:33:04,080 --> 02:33:13,840
COME IN AT ONCE.

2952
02:33:13,840 --> 02:33:16,400
AND I DON'T HAVE THE EXPERIENCE 

2953
02:33:16,400 --> 02:33:21,120
ADAM OR TARA HAD IN THIS SPACE 

2954
02:33:21,120 --> 02:33:22,880
BUT THE BAR SEEMS HIGHER HERE 

2955
02:33:22,880 --> 02:33:24,320
REFERRING TO THE QUESTIONS THAT 

2956
02:33:24,320 --> 02:33:24,920
NEED TO BE ADDRESSED AND SO 

2957
02:33:24,920 --> 02:33:35,040
FORTH.

2958
02:33:35,560 --> 02:33:42,880
I CAN SEE SOME COMMONALITIES.

2959
02:33:42,880 --> 02:33:46,080
>> BEFORE I LEFT DARPA
SOME 

2960
02:33:46,080 --> 02:33:48,720
SPENT TIME ON THE CREATIVITY AND

2961
02:33:48,720 --> 02:33:53,080
PUT IN PLACE SYSTEMS TO GAMIFY 

2962
02:33:53,080 --> 02:33:55,760
THIS AND ENGAGE AND THE FACT 

2963
02:33:55,760 --> 02:33:58,400
DARPA IS SEEING THAT AND I'M 

2964
02:33:58,400 --> 02:34:00,360
GOING TO TRY TO GET TIME ON YOUR

2965
02:34:00,360 --> 02:34:03,840
SCHEDULE AND ANYONE WHO WANTS TO

2966
02:34:03,840 --> 02:34:06,480
TALK OF WAYS TO DO THIS AND WE 

2967
02:34:06,480 --> 02:34:08,560
DON'T WANT TO END UP LIKE DARPA 

2968
02:34:08,560 --> 02:34:18,040
IN WHAT DO WE DO NOW.

2969
02:34:18,040 --> 02:34:19,200
>> GREAT.

2970
02:34:19,200 --> 02:34:21,200
ADAM, THE COUNCIL HAS BEEN A 

2971
02:34:21,200 --> 02:34:26,880
TREMENDOUS SOURCE OF KNOWLEDGE, 

2972
02:34:26,880 --> 02:34:29,760
IDEAS AND SO FORTH.

2973
02:34:29,760 --> 02:34:33,160
I APPRECIATE YOU'RE WELCOMING OF

2974
02:34:33,160 --> 02:34:34,000
THEIR REACHING OUT TO YOU FOR 

2975
02:34:34,000 --> 02:34:36,600
ANY SUGGESTIONS OR INPUT THEY 

2976
02:34:36,600 --> 02:34:44,400
MAY OFFER.

2977
02:34:44,400 --> 02:34:46,640
I THINK WE'LL FIND WE'RE 

2978
02:34:46,640 --> 02:34:47,960
OUTSTANDING PARTNERS 

2979
02:34:47,960 --> 02:34:48,960
REPRESENTING BROAD SECTIONS OF 

2980
02:34:48,960 --> 02:34:54,120
THE COUNTRY AND DIFFERENT 

2981
02:34:54,120 --> 02:34:57,120
DISCIPLINES AND SO FORTH.

2982
02:34:57,120 --> 02:35:00,640
WE'RE ABOUT AT THE TIME WE'RE 

2983
02:35:00,640 --> 02:35:03,360
SUPPOSED TO TAKE A BREAK.

2984
02:35:03,360 --> 02:35:05,720
I PRESUME YOU'LL USE THIS AS A 

2985
02:35:05,720 --> 02:35:06,200
LUNCH BREAK.

2986
02:35:06,200 --> 02:35:08,440
NOT SURE WHAT I WILL DO WITH IT 

2987
02:35:08,440 --> 02:35:10,680
ON THE WEST COAST BUT WE'LL 

2988
02:35:10,680 --> 02:35:11,760
FIGURE THAT OUT.

2989
02:35:11,760 --> 02:35:16,200
MAYBE I'LL CATCH UP ON E-MAIL.

2990
02:35:16,200 --> 02:35:20,920
I WANT TO THANK YOU ALL FOR WHAT

2991
02:35:20,920 --> 02:35:23,200
I HOPE YOU THINK SAY GOOD 

2992
02:35:23,200 --> 02:35:29,160
MORNING SECTION AND RECONVENE AT

2993
02:35:29,160 --> 02:35:33,080
1:30 P.M. EAST COAST TO HEAR AN 

2994
02:35:33,080 --> 02:35:36,120
UPDATE FROM TONY AND THEN THE 

2995
02:35:36,120 --> 02:35:37,920
REMAINDER OF THE PROGRAM AS 

2996
02:35:37,920 --> 02:35:38,320
OUTLINED.

2997
02:35:38,320 --> 02:35:41,120
THANKS EVERYBODY AND WE'LL 

2998
02:35:41,120 --> 02:35:47,960
RECONVENE AT 1:30.

2999
02:35:47,960 --> 02:35:53,120
>>NEXT WE WERE HEAR TO
TONY

3000
02:35:53,120 --> 02:35:57,240
AND COULDN'T JOIN US FOR THE 

3001
02:35:57,240 --> 02:36:00,720
WHOLE TIME SO HE RECORDED IT AND

3002
02:36:00,720 --> 02:36:04,120
HE'LL JOIN US FOR QUESTIONS AND 

3003
02:36:04,120 --> 02:36:04,480
REMARKS.

3004
02:36:04,480 --> 02:36:07,000
WE'LL GET TO INTERACT LIVE BUT 

3005
02:36:07,000 --> 02:36:08,960
THE SESSION WAS PRERECORDED A 

3006
02:36:08,960 --> 02:36:10,200
DAY OR SO AGO.

3007
02:36:10,200 --> 02:36:14,200
IF THE TEAM COULD QUEUE UP 

3008
02:36:14,200 --> 02:36:17,480
DR. FAUCI'S PRESENTATION.

3009
02:36:17,480 --> 02:36:27,840
THAT WOULD BE GREAT.

3010
02:36:31,880 --> 02:36:35,480
>> GREETINGS, EVERYONE'S A
GREAT

3011
02:36:35,480 --> 02:36:40,000
PLEASURE TO PROVIDE THE ACD WITH

3012
02:36:40,000 --> 02:36:42,240
AN UPDATE ON THE COVID-19 

3013
02:36:42,240 --> 02:36:42,520
PANDEMIC.

3014
02:36:42,520 --> 02:36:43,360
LET'S GET ON WITH THE DATA AND 

3015
02:36:43,360 --> 02:36:45,400
LOOK AT WHERE WE ARE NOW AND 

3016
02:36:45,400 --> 02:36:47,720
WHERE WE'RE PROJECTED TO BE.

3017
02:36:47,720 --> 02:36:50,280
THE DATA AGAIN ARE REALLY RATHER

3018
02:36:50,280 --> 02:36:52,760
SOBERING AS WE ALL KNOW.

3019
02:36:52,760 --> 02:36:55,920
GLOBALLY WE'RE NOW OVER HALF A 

3020
02:36:55,920 --> 02:36:59,440
BILLION CASES WITH MORE THAN 6.2

3021
02:36:59,440 --> 02:37:00,680
MILLION REPORTED DEATHS.

3022
02:37:00,680 --> 02:37:05,360
THE DEATH TOLL IS LIKELY ONE OF 

3023
02:37:05,360 --> 02:37:10,040
OR TWO FOLD GREATER THAN THAT 

3024
02:37:10,040 --> 02:37:13,920
ACCORDING TO THE W.H.O. 

3025
02:37:13,920 --> 02:37:17,760
PROJECTIONS CLOSER TO 15 MILLION

3026
02:37:17,760 --> 02:37:19,280
DEATHS IN THE U.S. WE HAVE GONE 

3027
02:37:19,280 --> 02:37:23,000
OVER THE TERRIBLE LANDMARK OF 1 

3028
02:37:23,000 --> 02:37:24,800
MILLION DEATHS AS SHOWN ON THE 

3029
02:37:24,800 --> 02:37:27,320
RIGHT SIDE WITH THE DARKNESS OF 

3030
02:37:27,320 --> 02:37:30,040
THE BLUE COLOR INDICATING THE 

3031
02:37:30,040 --> 02:37:33,280
INCREASE AND DENSITY OF CASES 

3032
02:37:33,280 --> 02:37:37,440
PER 100 TRIES TO AS DISTRIBUTED 

3033
02:37:37,440 --> 02:37:38,480
ACCORDING TO THE MAP.

3034
02:37:38,480 --> 02:37:41,160
IT'S BEEN TRULY A ROLLER COASTER

3035
02:37:41,160 --> 02:37:42,240
EFFECT SINCE THE BEGINNING OF 

3036
02:37:42,240 --> 02:37:43,480
THE OUTBREAK.

3037
02:37:43,480 --> 02:37:46,080
THE FIRST PERIOD OF TIME WITH 

3038
02:37:46,080 --> 02:37:51,560
REGARD TO CASES WAS WITH OMICRON

3039
02:37:51,560 --> 02:37:53,880
WHICH I'LL GET TO AS WE LOOK AT 

3040
02:37:53,880 --> 02:37:56,920
THE PEAKS AND WHAT VARIANT THEY 

3041
02:37:56,920 --> 02:37:58,680
REPRESENT.

3042
02:37:58,680 --> 02:38:00,440
WE WERE HAVING 800,000 TO 

3043
02:38:00,440 --> 02:38:02,720
900,000 CASES PER DAY.

3044
02:38:02,720 --> 02:38:08,120
RIGHT NOW WE'RE DOWN AROUND 

3045
02:38:08,120 --> 02:38:12,520
100,000 CASES A DAY IMPORTANTLY,

3046
02:38:12,520 --> 02:38:16,600
IF YOU LOOK AT THE DEATHS PER 

3047
02:38:16,600 --> 02:38:19,000
DAY IN PRIOR SURGES THEY WERE 

3048
02:38:19,000 --> 02:38:23,280
MORE REFLECTIVE OF THE NUMBER OF

3049
02:38:23,280 --> 02:38:25,520
CASES WHERE IF YOU LOOK AT ON 

3050
02:38:25,520 --> 02:38:28,640
THE FAR HAND RIGHT PART OF THE 

3051
02:38:28,640 --> 02:38:30,880
SLIDE THOUGH WE HAVE A LOT OF 

3052
02:38:30,880 --> 02:38:33,320
CASES SURGING THE RATIO OF 

3053
02:38:33,320 --> 02:38:37,480
HOSPITALIZATIONS AND DEATHS TO 

3054
02:38:37,480 --> 02:38:44,880
CASES IS MUCH LOWER.

3055
02:38:44,880 --> 02:38:45,680
AND WE HAD LESS TOTAL NUMBER OF 

3056
02:38:45,680 --> 02:38:55,800
CASES.

3057
02:39:01,560 --> 02:39:03,920
BOTTOM LINE LESS 

3058
02:39:03,920 --> 02:39:04,320
HOSPITALIZATIONS.

3059
02:39:04,320 --> 02:39:06,960
WE CONTINUE TO HAVE A DISPARITY 

3060
02:39:06,960 --> 02:39:09,840
OF A GREATER PROPENSITY TOWARDS 

3061
02:39:09,840 --> 02:39:11,320
SEVERITY IN MINORITY GROUPS.

3062
02:39:11,320 --> 02:39:12,840
IF YOU LOOK AT THE GRAY BAR 

3063
02:39:12,840 --> 02:39:15,720
WHICH IS THE STANDARD OF THE 

3064
02:39:15,720 --> 02:39:18,240
WHITE POPULATION AND LOOK AT THE

3065
02:39:18,240 --> 02:39:22,280
FOLD INCREASE IN CASES, 

3066
02:39:22,280 --> 02:39:23,120
HOSPITALIZATIONS AND DEATHS 

3067
02:39:23,120 --> 02:39:27,240
AMONG BLACKS IN DARK BLUE, 

3068
02:39:27,240 --> 02:39:29,280
HISPANICS IN RED, AMERICAN 

3069
02:39:29,280 --> 02:39:31,720
INDIAN OR ALASKAN NATIVES IN 

3070
02:39:31,720 --> 02:39:33,280
LIGHT BLUE, IT'S CLEAR WE 

3071
02:39:33,280 --> 02:39:36,640
CONTINUE TO HAVE THIS DISPARITY 

3072
02:39:36,640 --> 02:39:40,080
WHEN IT COMES SEVERITY OF 

3073
02:39:40,080 --> 02:39:40,320
DISEASE.

3074
02:39:40,320 --> 02:39:43,440
CHILDREN ARE CLEARLY AFFECTED.

3075
02:39:43,440 --> 02:39:47,480
THERE HAD BEEN THIS FEELING IF 

3076
02:39:47,480 --> 02:39:50,880
NOT EXPRESSED CONCERN THAT WE 

3077
02:39:50,880 --> 02:39:53,400
WERE OVER EMPHASIZING THE 

3078
02:39:53,400 --> 02:39:54,240
SITUATION WITH CHILDREN AND 

3079
02:39:54,240 --> 02:39:56,920
THEIR RISK OF INFECTION AND/OR 

3080
02:39:56,920 --> 02:39:58,960
DISEASE WAS VERY LOW.

3081
02:39:58,960 --> 02:40:00,920
CERTAINLY IT IS LOWER THAN IN AN

3082
02:40:00,920 --> 02:40:04,160
ADULT PARTICULARLY ELDERLY 

3083
02:40:04,160 --> 02:40:05,280
ADULTS, BUT CHILDREN CLEARLY ARE

3084
02:40:05,280 --> 02:40:07,200
VULNERABLE NOT ONLY TO INFECTION

3085
02:40:07,200 --> 02:40:11,400
AS SHOWN, BUT THE FACT THERE'S 

3086
02:40:11,400 --> 02:40:13,760
BEEN OVER 15 MILLION CASE IN 

3087
02:40:13,760 --> 02:40:18,600
CHILDREN AND OVER 8,000 CHILDREN

3088
02:40:18,600 --> 02:40:21,480
HAVE EXPERIENCED THE VERY 

3089
02:40:21,480 --> 02:40:24,480
SERIOUS MULTI-SYSTEM 

3090
02:40:24,480 --> 02:40:25,480
INFLAMMATORY SYNDROME.

3091
02:40:25,480 --> 02:40:28,120
THERE HAVE BEEN OVER 1500 

3092
02:40:28,120 --> 02:40:28,360
DEATHS.

3093
02:40:28,360 --> 02:40:31,320
THE DEATHS FROM COVID AMONG 

3094
02:40:31,320 --> 02:40:32,840
CHILDREN ARE CLEARLY GREATER 

3095
02:40:32,840 --> 02:40:34,400
NUMERICALLY THAN THE NUMBER OF 

3096
02:40:34,400 --> 02:40:36,640
DEATHS WE GET PER YEAR WITH 

3097
02:40:36,640 --> 02:40:43,120
CHILDREN WITH INFLUENZA.

3098
02:40:43,120 --> 02:40:44,760
THOSE SURGES YOU SAW WERE 

3099
02:40:44,760 --> 02:40:46,840
ASSOCIATED WITH THE EMERGENCE OF

3100
02:40:46,840 --> 02:40:48,720
DIFFERENT VARIANTS.

3101
02:40:48,720 --> 02:40:50,880
HERE'S THE VARIANTS SHOWING THE 

3102
02:40:50,880 --> 02:40:52,440
DATES IN WHICH THE EARLIEST 

3103
02:40:52,440 --> 02:40:53,120
DOCUMENTED SAMPLES OF THAT 

3104
02:40:53,120 --> 02:40:55,560
VARIANT WAS SEEN.

3105
02:40:55,560 --> 02:41:03,520
WE ARE CURRENTLY NOW IN AN 

3106
02:41:03,520 --> 02:41:05,400
OMICRON VARIANT BUT A VARIANT 

3107
02:41:05,400 --> 02:41:07,760
FROM SEVERAL STANDPOINTS.

3108
02:41:07,760 --> 02:41:10,160
IF YOU LOOK AT THE IT VARIATIONS

3109
02:41:10,160 --> 02:41:12,160
AND COMPARED DELTA ON THE LEFT 

3110
02:41:12,160 --> 02:41:14,000
WITH OMICRON ON THE RIGHT, THE 

3111
02:41:14,000 --> 02:41:17,520
NUMBER OF MUTATIONS ARE CLEARLY 

3112
02:41:17,520 --> 02:41:19,600
MUCH MUCH GREATER.

3113
02:41:19,600 --> 02:41:21,880
A TOTAL OF 50.

3114
02:41:21,880 --> 02:41:26,560
30 OF WHICH IN THE SPIKE PROTEIN

3115
02:41:26,560 --> 02:41:29,680
AND ABOUT A DOZEN OR SO ARE IN 

3116
02:41:29,680 --> 02:41:34,120
THE RECEPTOR BINDING DOMAIN 

3117
02:41:34,120 --> 02:41:37,320
MAKING IT A MUCH MORE 

3118
02:41:37,320 --> 02:41:39,960
TRANSMISSIBLE THOUGH APPARENTLY 

3119
02:41:39,960 --> 02:41:44,400
LESS SEVERE TO THE POINT OF NOT 

3120
02:41:44,400 --> 02:41:45,840
CAUSING SERIOUS DISEASE AND 

3121
02:41:45,840 --> 02:41:48,800
DEATH IN VULNERABLE INDIVIDUALS 

3122
02:41:48,800 --> 02:41:50,440
WHICH CLEARLY WE'LL SHOW YOU IN 

3123
02:41:50,440 --> 02:41:58,560
A MOMENT WHY THAT'S THE CASE AND

3124
02:41:58,560 --> 02:42:00,600
SHOWN IN THE DEATH NUMBER OF A 

3125
02:42:00,600 --> 02:42:03,600
PRIOR SLIDE, OMICRON, THOUGH 

3126
02:42:03,600 --> 02:42:05,280
MORE HIGHLY TRANSMISSIBLE 

3127
02:42:05,280 --> 02:42:06,280
APPEARS TO BE LESS SEVERE THAN 

3128
02:42:06,280 --> 02:42:07,920
WHAT WE EXPERIENCED WITH DELTA.

3129
02:42:07,920 --> 02:42:10,320
BUT IF YOU LOOK AT THE SO-CALLED

3130
02:42:10,320 --> 02:42:15,280
FAMILY TREE, YOU CAN SEE THAT 

3131
02:42:15,280 --> 02:42:20,760
ALTHOUGH OMICRON CAME WAY OUT 

3132
02:42:20,760 --> 02:42:26,120
FROM THE ALPHA, BETA, LAMBDA AND

3133
02:42:26,120 --> 02:42:29,480
THE ORIGINAL WUHAN WE'RE SEEING 

3134
02:42:29,480 --> 02:42:31,920
THE SUCCESSIVE LINEAGES WITHIN 

3135
02:42:31,920 --> 02:42:34,640
THE OMICRON VARIANT.

3136
02:42:34,640 --> 02:42:37,920
THAT'S WHAT A CIRCLED IN RED AND

3137
02:42:37,920 --> 02:42:38,880
IT'S BEEN AN INTERESTING 

3138
02:42:38,880 --> 02:42:39,520
EVOLUTION IN THE UNITED STATES 

3139
02:42:39,520 --> 02:42:44,520
AND OTHER COUNTRIES I'LL SHOW 

3140
02:42:44,520 --> 02:42:49,480
YOU IN A MOMENT.

3141
02:42:49,480 --> 02:42:52,800
WHEN YOU HAVE A VARIANT WITH ANY

3142
02:42:52,800 --> 02:42:54,400
DEGREE OF VARIANT IT THE PUSHES 

3143
02:42:54,400 --> 02:42:55,240
THE PRIOR VARIANT OFF THE MAP 

3144
02:42:55,240 --> 02:42:58,440
AND REPLACE IT AS WE SEE WHAT 

3145
02:42:58,440 --> 02:43:01,360
DELTA DID OVER TIME TO ALPHA, 

3146
02:43:01,360 --> 02:43:04,000
BETA AND GAMMA AND WITH OMICRON 

3147
02:43:04,000 --> 02:43:05,440
WHICH WAS MUCH DIFFERENT AND 

3148
02:43:05,440 --> 02:43:08,120
RAPIDLY PUSHED DELTA OFF THE MAP

3149
02:43:08,120 --> 02:43:10,440
AS SHOWN HERE IN THE TIME COURSE

3150
02:43:10,440 --> 02:43:14,720
OF THE VARIANT DISTRIBUTION.

3151
02:43:14,720 --> 02:43:16,320
SO LET'S GET BACK TO THE 

3152
02:43:16,320 --> 02:43:18,200
DIFFERENT VARIANTS AND SHOW HOW 

3153
02:43:18,200 --> 02:43:20,400
THEY COINCIDED WITH THE SURGES 

3154
02:43:20,400 --> 02:43:22,480
WE'VE SEEN GLOBALLY.

3155
02:43:22,480 --> 02:43:25,480
AS YOU CAN SEE GOING FROM MARCH 

3156
02:43:25,480 --> 02:43:29,920
1, 2020 UNTIL THE ENDS OF MAY, 

3157
02:43:29,920 --> 02:43:33,480
WE HAD THESE PEAKS, WHICH DEATH 

3158
02:43:33,480 --> 02:43:34,400
WAS ASSOCIATED IN A HIGHER 

3159
02:43:34,400 --> 02:43:37,480
DEGREE PARTICULARLY WITH DELTA 

3160
02:43:37,480 --> 02:43:40,600
BUT OMICRON, NUMERICALLY IN 

3161
02:43:40,600 --> 02:43:42,960
NUMBER OF CASES WAS THE LARGEST 

3162
02:43:42,960 --> 02:43:43,640
SPIKE WE HAVE SEEN.

3163
02:43:43,640 --> 02:43:45,280
AS WE MENTION THERE WAS A POINT 

3164
02:43:45,280 --> 02:43:47,720
THERE WHERE WE WERE CLOSE TO 

3165
02:43:47,720 --> 02:43:52,480
900,000 CASES PER DAY.

3166
02:43:52,480 --> 02:43:53,960
THAT HAD RAPIDLY GONE DOWN BUT 

3167
02:43:53,960 --> 02:43:59,000
NOW AS WE'RE SEEING AS SHOWN IN 

3168
02:43:59,000 --> 02:44:00,600
THIS GRAPH FROM THE UNITED 

3169
02:44:00,600 --> 02:44:03,840
STATES ON THE FAR RIGHT HAND 

3170
02:44:03,840 --> 02:44:06,200
PART OF THE SLIDE WE'RE SEEING A

3171
02:44:06,200 --> 02:44:09,200
NEW SURGE IN CASES BRINGING US 

3172
02:44:09,200 --> 02:44:13,520
NOW TO AN AVERAGE OF ABOUT 

3173
02:44:13,520 --> 02:44:15,760
100,000 CASES OR MORE PER DAY 

3174
02:44:15,760 --> 02:44:19,280
AND ABOUT 300 DEATHS PER DAY.

3175
02:44:19,280 --> 02:44:21,240
AGAIN, THE DISPARITY BETWEEN A 

3176
02:44:21,240 --> 02:44:24,720
LARGE NUMBER OF CASES AND 

3177
02:44:24,720 --> 02:44:26,600
RELATIVELY FEWER DEATHS BUT 300 

3178
02:44:26,600 --> 02:44:27,640
DEATHS IS STILL SOMETHING TO BE 

3179
02:44:27,640 --> 02:44:36,320
TAKEN TO BE SERIOUSLY.

3180
02:44:36,320 --> 02:44:37,600
IN THE UNITED STATES FROM LEFT 

3181
02:44:37,600 --> 02:44:39,640
TO RIGHT YOU HAVE SEEN THE 

3182
02:44:39,640 --> 02:44:42,080
REPLACEMENT OF ONE SUB LINEAGE 

3183
02:44:42,080 --> 02:44:45,560
OF OHM FROM THE OTHER GOING FROM

3184
02:44:45,560 --> 02:44:52,280
ORANGE 1.1 TO THE LIGHTER PURPLE

3185
02:44:52,280 --> 02:45:00,480
BA2 AND TO DARKER PURPLE BA21.1 

3186
02:45:00,480 --> 02:45:04,560
TAKEN OVER BA2 AND ACCOUNTS FOR 

3187
02:45:04,560 --> 02:45:07,600
APPROXIMATELY 60% OF THE 

3188
02:45:07,600 --> 02:45:09,080
ISOLATES WE'RE SEEING IN THE 

3189
02:45:09,080 --> 02:45:09,560
UNITED STATES.

3190
02:45:09,560 --> 02:45:12,800
GO FOR A MOMENT TO SOUTH AFRICA 

3191
02:45:12,800 --> 02:45:14,040
WHICH EXPERIENCED THE SAME SORT 

3192
02:45:14,040 --> 02:45:18,440
OF EVOLUTION OF ONE VARIANT TO 

3193
02:45:18,440 --> 02:45:18,640
ANOTHER.

3194
02:45:18,640 --> 02:45:21,080
THEIR EXPERIENCE OF VARIANT BA4 

3195
02:45:21,080 --> 02:45:26,480
AND BA5 IN SOUTH AFRICA.

3196
02:45:26,480 --> 02:45:28,720
WE HAVE APPROXIMATELY LESS THAN 

3197
02:45:28,720 --> 02:45:32,120
1% OF BA4, BA5 BUT IT'S 

3198
02:45:32,120 --> 02:45:34,640
GRADUALLY CREEPING UP.

3199
02:45:34,640 --> 02:45:38,280
WHETHER OR NOT IT WILL OUT 

3200
02:45:38,280 --> 02:45:43,680
COMPETE BA2.12.1 WE DO NOT KNOW.

3201
02:45:43,680 --> 02:45:45,400
OUR COLLEAGUES IN SOUTH AFRICA 

3202
02:45:45,400 --> 02:45:49,880
TELL US BA4 AND BA5 ARE OUT 

3203
02:45:49,880 --> 02:45:51,960
COMPETING OTHERS BUT THE 

3204
02:45:51,960 --> 02:45:53,880
SEVERITY IS RELATIVELY LOW 

3205
02:45:53,880 --> 02:45:56,080
COMPARED TO THE PRIOR EXPERIENCE

3206
02:45:56,080 --> 02:46:00,400
WITH DELTA.

3207
02:46:00,400 --> 02:46:01,520
THIS IS A GRAPHIC DEMONSTRATION 

3208
02:46:01,520 --> 02:46:04,120
OF THE LATTER OF 

3209
02:46:04,120 --> 02:46:04,520
TRANSMISSIBILITY.

3210
02:46:04,520 --> 02:46:06,520
WHEN YOU LOOK AT THE DIFFERENCE 

3211
02:46:06,520 --> 02:46:09,760
BETWEEN DELTA AND OMICRON THE 

3212
02:46:09,760 --> 02:46:13,800
BIG JUMP OF A MULTIFOLD 

3213
02:46:13,800 --> 02:46:15,560
DIFFERENCE AND GREATER 

3214
02:46:15,560 --> 02:46:16,200
TRANSMISSIBILITY AS YOU PROGRESS

3215
02:46:16,200 --> 02:46:23,920
FROM BA2, BA21.1 AND BA4 AND 

3216
02:46:23,920 --> 02:46:24,120
BA5.

3217
02:46:24,120 --> 02:46:28,400
WHAT IS THIS ALL ABOUT?

3218
02:46:28,400 --> 02:46:30,440
WHY ARE WE SEEING AN INCREASE IN

3219
02:46:30,440 --> 02:46:33,160
CASES BRINGS US OVER 100,000 

3220
02:46:33,160 --> 02:46:34,720
CASES PER DAY?

3221
02:46:34,720 --> 02:46:36,240
IT RELATES TO THE INCREASED 

3222
02:46:36,240 --> 02:46:36,760
TRANSMISSIBILITY OF THE 

3223
02:46:36,760 --> 02:46:37,040
VARIANTS.

3224
02:46:37,040 --> 02:46:39,600
NO DOUBT THAT IS THE CASE.

3225
02:46:39,600 --> 02:46:43,840
ALSO THERE'S A COMBINATION OF 

3226
02:46:43,840 --> 02:46:49,120
WANING IMMUNITY EITHER TO PRIOR 

3227
02:46:49,120 --> 02:46:49,720
INFECTION AND/OR VACCINATION 

3228
02:46:49,720 --> 02:46:52,680
WITH BOOSTS AND HAVE SEEN PEOPLE

3229
02:46:52,680 --> 02:46:54,560
INFECTED PREVIOUSLY OR 

3230
02:46:54,560 --> 02:46:56,200
VACCINATED GETTING INFECTED.

3231
02:46:56,200 --> 02:46:58,120
THERE'S NO DOUBT ABOUT THE 

3232
02:46:58,120 --> 02:46:59,560
WANING IMMUNITY WE'RE SEEING 

3233
02:46:59,560 --> 02:47:02,480
FROM NATURAL INFECTION AND FROM 

3234
02:47:02,480 --> 02:47:07,280
VACCINATION BUT ALSO THIS C

3235
02:47:07,280 --> 02:47:08,800
COINCIDES WITH THE GENERAL 

3236
02:47:08,800 --> 02:47:10,040
FEELINGS IN THE COUNTRY WE WANT 

3237
02:47:10,040 --> 02:47:11,400
TO PUT THE OUTBREAK BEHIND US 

3238
02:47:11,400 --> 02:47:13,480
AND THERE'S BEEN A SIGNIFICANT 

3239
02:47:13,480 --> 02:47:16,680
RELAXATION OF MITIGATIONS WITH 

3240
02:47:16,680 --> 02:47:18,680
MASKING NOW NO LONGER 

3241
02:47:18,680 --> 02:47:20,800
COMMONPLACE INDOOR AND A NUMBER 

3242
02:47:20,800 --> 02:47:22,800
OF PEOPLE INDOOR CONGREGATING IN

3243
02:47:22,800 --> 02:47:24,320
BARS AND RESTAURANTS AND IN 

3244
02:47:24,320 --> 02:47:34,720
PLACES OF ENTERTAINMENT.

3245
02:47:39,040 --> 02:47:42,160
LET'S MOVE ON TO THE MEDICAL 

3246
02:47:42,160 --> 02:47:42,480
MANAGEMENT.

3247
02:47:42,480 --> 02:47:45,040
THE MEDICAL MANAGEMENT HAS THREE

3248
02:47:45,040 --> 02:47:45,480
COMPONENTS.

3249
02:47:45,480 --> 02:47:48,160
THE CONTROL OF SYMPTOMS THAT 

3250
02:47:48,160 --> 02:47:50,040
DON'T REQUIRE HOSPITALIZATIONS.

3251
02:47:50,040 --> 02:47:53,240
THE PEOPLE WHO GET MILD UPPER 

3252
02:47:53,240 --> 02:47:55,040
RESPIRATORY SYMPTOMS WHO STAY AT

3253
02:47:55,040 --> 02:48:00,600
HOME ANYWHERE SEVERAL DAYS TO 

3254
02:48:00,600 --> 02:48:05,640
WEEKS.

3255
02:48:05,640 --> 02:48:09,560
GENERALLY CONTROLLED 

3256
02:48:09,560 --> 02:48:11,880
ANTI-INFLAMMATORY AND NEXT IS 

3257
02:48:11,880 --> 02:48:18,560
END ORGAN SUPPORT 

3258
02:48:18,560 --> 02:48:22,680
HOSPITALIZATIONS WITH DEVICE OR 

3259
02:48:27,640 --> 02:48:29,920
ECMO AND THEN THERE'S THE 

3260
02:48:29,920 --> 02:48:33,480
ANTIVIRALS AND IMMUNOMODULATORS.

3261
02:48:33,480 --> 02:48:34,920
WE HAVE PUT FORTH TREATMENT 

3262
02:48:34,920 --> 02:48:40,040
GUIDELINES THAT PHYSICIANS AND 

3263
02:48:40,040 --> 02:48:41,160
OTHER INTERESTED PARTIES CAN 

3264
02:48:41,160 --> 02:48:42,880
ACCESS ONLINE AND LOOK AT THE 

3265
02:48:42,880 --> 02:48:43,800
LATEST DATA AS IT UNFOLDS IN 

3266
02:48:43,800 --> 02:48:51,280
REAL TIME.

3267
02:48:51,280 --> 02:48:52,960
IT'S A VALUED RESOURCE AND THE 

3268
02:48:52,960 --> 02:48:54,440
NIH GUIDELINES HAVE RESOURCED 

3269
02:48:54,440 --> 02:48:57,600
MILLIONS OF HITS THROUGHOUT THE 

3270
02:48:57,600 --> 02:48:59,240
WORLD OF PEOPLE UTILIZING IT TO 

3271
02:48:59,240 --> 02:49:01,840
TREAT AND MANAGE PATIENTS.

3272
02:49:01,840 --> 02:49:03,040
IF ONE LOOKS AT THERAPEUTICS 

3273
02:49:03,040 --> 02:49:09,040
THERE'S TWO APPROACHES, ONE TO 

3274
02:49:09,040 --> 02:49:10,040
DIRECTLY TARGET THE VIRUS AND WE

3275
02:49:10,040 --> 02:49:11,760
HAVE A NUMBER OF INTERVENTIONS.

3276
02:49:11,760 --> 02:49:14,360
ONE OF WHICH IS FULLY FDA 

3277
02:49:14,360 --> 02:49:21,680
APPROVED AND OTHERS AND THE ONLY

3278
02:49:21,680 --> 02:49:26,200
ONE STILL EFFECTIVE AGAINST THE 

3279
02:49:26,200 --> 02:49:34,840
OMICRON IS THE BEBTELOVIMAB AND 

3280
02:49:34,840 --> 02:49:37,320
MODERATING A HOST RESPONSE 

3281
02:49:37,320 --> 02:49:43,640
USUALLY LATE IN THE COURT THAT 

3282
02:49:43,640 --> 02:49:46,960
UTIL

3283
02:49:46,960 --> 02:49:57,400
UTILIZE DEXAMETHASOME AND 

3284
02:49:59,640 --> 02:50:02,360
TOCL

3285
02:50:02,360 --> 02:50:02,640
TOCLIZUMAB.

3286
02:50:02,640 --> 02:50:05,760
I PUT UP THE TOOL KIT FOR 

3287
02:50:05,760 --> 02:50:07,280
NON-HOSPITALIZED PATIENTS.

3288
02:50:07,280 --> 02:50:10,240
THE CRITICAL ISSUE ARE 

3289
02:50:10,240 --> 02:50:11,480
INTERVENTIONS ARE TO KEEM PEOPLE

3290
02:50:11,480 --> 02:50:12,800
OUT OF THE HOSPITAL AND TREAT 

3291
02:50:12,800 --> 02:50:13,400
THEM EARLY IN THE COURSE OF 

3292
02:50:13,400 --> 02:50:17,040
INFECTION.

3293
02:50:17,040 --> 02:50:17,880
THERE'S A NUMBER OF 

3294
02:50:17,880 --> 02:50:19,880
INTERVENTIONS HERE THE MOST 

3295
02:50:19,880 --> 02:50:23,520
EFFECTIVE OF WHICH AND THE EASE 

3296
02:50:23,520 --> 02:50:26,040
OF ADMINISTRATION OF WHICH IS 

3297
02:50:26,040 --> 02:50:26,280
PAXLOVID.

3298
02:50:26,280 --> 02:50:28,640
IN ADDITION, WE HAVE THE 

3299
02:50:28,640 --> 02:50:31,520
RECENTLY SHOWN TO BE EFFECTIVE 

3300
02:50:31,520 --> 02:50:37,200
AGAINST THE OMICRON VARIANT THE 

3301
02:50:37,200 --> 02:50:42,120
MONOCLONAL ANTI

3302
02:50:42,120 --> 02:50:45,760
MONOCLONAL ANTIBODY.

3303
02:50:45,760 --> 02:50:51,280
THERE ARE SITES NOW AT LEAST 

3304
02:50:51,280 --> 02:50:54,520
2200 AND MORE TO COME IN WHICH 

3305
02:50:54,520 --> 02:50:57,280
ONE CAN GET TESTED ON THE SPOT 

3306
02:50:57,280 --> 02:50:59,080
IF POSITIVE WITH AN ANTIGEN TEST

3307
02:50:59,080 --> 02:51:03,600
TO GET AT THE TIME IN REAL TIME 

3308
02:51:03,600 --> 02:51:14,080
PAXLOVID TO BE ADMINISTERED.

3309
02:51:21,040 --> 02:51:22,720
TREATING EARLY ON IS EFFECTIVE.

3310
02:51:22,720 --> 02:51:25,560
WE HAVE MULTIPLE VACCINES.

3311
02:51:25,560 --> 02:51:29,480
WE HAVE THE mRNA  VACCINES AND 

3312
02:51:29,480 --> 02:51:32,480
THE J & J WHICH IS NOT
UTILIZED 

3313
02:51:32,480 --> 02:51:33,480
AS MUCH NOW IN THE UNITED STATES

3314
02:51:33,480 --> 02:51:39,320
AND THEN WE HAVE OTHERS THAT IS 

3315
02:51:39,320 --> 02:51:45,360
THE ASTRAZENECA AND NOVA VAX IN 

3316
02:51:45,360 --> 02:51:47,400
DIFFERENT LEVELS OF DEVELOPMENT 

3317
02:51:47,400 --> 02:51:49,440
AND IN CERTAIN SITUATIONS WITH 

3318
02:51:49,440 --> 02:51:51,200
THE EUAs ALREADY GRANTED.

3319
02:51:51,200 --> 02:51:53,520
IF YOU LOOK AT THE EFFECT OF 

3320
02:51:53,520 --> 02:51:54,680
VACCINES, IT'S EXTRAORDINARY.

3321
02:51:54,680 --> 02:51:58,040
I COULD SHOW YOU 15 SLIDES OF 

3322
02:51:58,040 --> 02:52:00,240
THE DIFFERENCES BETWEEN 

3323
02:52:00,240 --> 02:52:01,600
INDIVIDUALS WHO ARE VACCINATED 

3324
02:52:01,600 --> 02:52:05,480
AND BOOSTED VERSUS UNVACCINATED 

3325
02:52:05,480 --> 02:52:06,920
INDIVIDUALS.

3326
02:52:06,920 --> 02:52:09,120
ON THE AFFECT OF VACCINATIONS IN

3327
02:52:09,120 --> 02:52:11,920
PREVENTING INFECTION TO SOME 

3328
02:52:11,920 --> 02:52:12,440
EXTENT BUT CERTAINLY 

3329
02:52:12,440 --> 02:52:14,760
HOSPITALIZATIONS AND DEATHS IT'S

3330
02:52:14,760 --> 02:52:16,480
ESTIMATED THAT BETWEEN DECEMBER 

3331
02:52:16,480 --> 02:52:20,200
OF 2020 AND MARCH OF 2022 OVER 2

3332
02:52:20,200 --> 02:52:23,400
MILLION DEATHS WERE AVERTED, 

3333
02:52:23,400 --> 02:52:24,880
MORE THAN 17 MILLION 

3334
02:52:24,880 --> 02:52:26,400
HOSPITALIZATIONS WERE AVERTED, 

3335
02:52:26,400 --> 02:52:28,240
MORE THAN 66 MILLION INFECTIONS 

3336
02:52:28,240 --> 02:52:32,640
WERE AVERTED AND HEALTH CARE 

3337
02:52:32,640 --> 02:52:34,040
COSTS APPROXIMATING $900 BILLION

3338
02:52:34,040 --> 02:52:38,040
HAVE BEEN SAVED.

3339
02:52:38,040 --> 02:52:41,240
THAT'S THE GOOD NEWS.

3340
02:52:41,240 --> 02:52:44,280
THE SOBERING NEWS IS WE NEED TO 

3341
02:52:44,280 --> 02:52:49,240
DO BETTER ON GETTING PEOPLE 

3342
02:52:49,240 --> 02:52:53,640
VACCINATED.

3343
02:52:53,640 --> 02:52:58,600
AND 71% OF INDIVIDUALS 5 YEARS 

3344
02:52:58,600 --> 02:53:00,680
OF AGE ARE VACCINATED AND WE'RE 

3345
02:53:00,680 --> 02:53:05,240
DOING BETTER WITH THE ELDERLY 

3346
02:53:05,240 --> 02:53:07,080
WITH OVER 91% FULLY VACCINATED.

3347
02:53:07,080 --> 02:53:12,120
WE MUST DO BETTER AS A COUNTRY 

3348
02:53:12,120 --> 02:53:15,120
WE ARE LAGGING BEHIND LOW AND 

3349
02:53:15,120 --> 02:53:16,720
MIDDLE INCOME COUNTRIES AS 

3350
02:53:16,720 --> 02:53:17,480
PERCENTAGE OF POPULATION THAT 

3351
02:53:17,480 --> 02:53:27,760
ARE VACCINATED.

3352
02:53:37,640 --> 02:53:42,680
THERE WILL BE A MEETING OF THE 

3353
02:53:42,680 --> 02:53:50,440
MODERNA REQUEST OF CHILDREN OF 6

3354
02:53:50,440 --> 02:54:00,880
YEARS TO 17 YEARS AND THE 

3355
02:54:05,040 --> 02:54:06,000
BIONTECH IS APPROVED AND 

3356
02:54:06,000 --> 02:54:08,920
THERE'LL BE A REQUEST FOR THE 

3357
02:54:08,920 --> 02:54:10,440
YOUNGER AGE GROUPS, 6 MONTHS 

3358
02:54:10,440 --> 02:54:15,280
THROUGH 5 YEARS OF AGE AND THE 

3359
02:54:15,280 --> 02:54:17,480
BIONTECH EUA REQUEST FOR 

3360
02:54:17,480 --> 02:54:18,720
CHILDREN 6 MONTHS THROUGH FOUR 

3361
02:54:18,720 --> 02:54:19,480
YEARS OF AGE.

3362
02:54:19,480 --> 02:54:21,920
SO IN THE NEXT COUPLE OF WEEKS 

3363
02:54:21,920 --> 02:54:32,480
THERE'LL BE A LOT OF AC   -- A 

3364
02:54:39,800 --> 02:54:40,280
LOT OF REQUESTS.

3365
02:54:40,280 --> 02:54:44,560
AND IN ADDITION TO HOW POORLY WE

3366
02:54:44,560 --> 02:54:46,560
DO COMPARED TO MIDDLE AND 

3367
02:54:46,560 --> 02:54:50,920
LOW-INCOME COUNTRIES, 87% OF 

3368
02:54:50,920 --> 02:54:52,640
PEOPLE IN THE MIDDLE-INCOME 

3369
02:54:52,640 --> 02:54:54,000
COUNTRIES HAVE A PROTOCOL WHERE 

3370
02:54:54,000 --> 02:54:55,320
IT'S 67%.

3371
02:54:55,320 --> 02:54:56,840
THE BAD NEWS ABOUT THIS SLIDE IS

3372
02:54:56,840 --> 02:55:00,120
THAT IF YOU LOOK AT THE LOWER 

3373
02:55:00,120 --> 02:55:03,560
INCOME COUNTRIES PARTICULARLY 

3374
02:55:03,560 --> 02:55:04,440
SOUTHERN AFRICAN COUNTRIES WE'RE

3375
02:55:04,440 --> 02:55:14,960
STILL AT A LOW LEVELS AND SO 

3376
02:55:16,240 --> 02:55:20,360
MANY REASONS AND INITIALLY THE 

3377
02:55:20,360 --> 02:55:21,720
SUPPLY AND THERE'S TWO ELEMENTS 

3378
02:55:21,720 --> 02:55:24,400
TO THE BOOSTER SITUATION.

3379
02:55:24,400 --> 02:55:25,800
THE FIRST IS THE INITIAL BOOST 

3380
02:55:25,800 --> 02:55:28,280
OVER AND ABOVE THE PRIMARY 

3381
02:55:28,280 --> 02:55:28,560
REGIMENT.

3382
02:55:28,560 --> 02:55:33,480
THAT WOULD BE A THIRD SHOT FOR 

3383
02:55:33,480 --> 02:55:35,960
AN mRNA  REGIMENT AND TWO SHOTS 

3384
02:55:35,960 --> 02:55:37,480
AND THE FOURTH SHOT OR THE 

3385
02:55:37,480 --> 02:55:39,480
SECOND BOOST OF THAT REGIMENT.

3386
02:55:39,480 --> 02:55:42,880
LET'S TAKE A LOOK AT THE INITIAL

3387
02:55:42,880 --> 02:55:51,800
BOOST OR THE THIRD SHOT FIRST.

3388
02:55:51,800 --> 02:55:52,960
THE COMMUNITY AGAINST THE 

3389
02:55:52,960 --> 02:55:55,280
VACCINE AND THE INITIAL EFFECT 

3390
02:55:55,280 --> 02:55:59,600
WAS 94% TO 95% EFFICACY AGAINST 

3391
02:55:59,600 --> 02:56:01,520
SYMPTOMATIC DISEASE HAS WANED 

3392
02:56:01,520 --> 02:56:04,040
OVER TIME WITH ALL THREE OF THE 

3393
02:56:04,040 --> 02:56:08,080
EFFECTIVE VACCINES WE USE IN 

3394
02:56:08,080 --> 02:56:09,880
THIS COUNTRY.

3395
02:56:09,880 --> 02:56:14,720
JOHNSON, MODERNA AND THE PFIZER,

3396
02:56:14,720 --> 02:56:16,600
BIONTECH AND THE REAL WORLD 

3397
02:56:16,600 --> 02:56:18,960
STUDIES HAVE SHOWN IF YOU GIVE A

3398
02:56:18,960 --> 02:56:22,040
THIRD SHOT BOOSTER DOSE IT DOES 

3399
02:56:22,040 --> 02:56:25,560
RECONSTITUTE WANING IMMUNE 

3400
02:56:25,560 --> 02:56:26,560
PROTECTION AT LEAST FOR A 

3401
02:56:26,560 --> 02:56:28,440
SEVERAL MONTH DURATION AND THE 

3402
02:56:28,440 --> 02:56:30,880
EFFECT OF THE BOOSTER DOSE IS 

3403
02:56:30,880 --> 02:56:33,920
MOST PRONOUNCED AGAINST SEVERE 

3404
02:56:33,920 --> 02:56:35,600
DISEASE, HOSPITALIZATIONS AND 

3405
02:56:35,600 --> 02:56:35,840
DEATHS.

3406
02:56:35,840 --> 02:56:41,440
I'VE ALLUDED TO THAT MULTIPLE 

3407
02:56:41,440 --> 02:56:46,040
TIMES WHEN YOU LOOK AT 

3408
02:56:46,040 --> 02:56:48,520
EPIDEMIOLOGY IN THE COUNTRY IN 

3409
02:56:48,520 --> 02:56:51,120
THE ERA OF OMICRON AND SEVERITY 

3410
02:56:51,120 --> 02:56:56,840
OF DISEASE AND DEATH IS LOWER 

3411
02:56:56,840 --> 02:57:00,800
PROPORTIONATELY TO INFECTION.

3412
02:57:00,800 --> 02:57:02,320
HERE'S THE AFFECT OF 

3413
02:57:02,320 --> 02:57:03,960
UNVACCINATED INDIVIDUALS IF YOU 

3414
02:57:03,960 --> 02:57:05,480
LOOK AT THE RATE OF 

3415
02:57:05,480 --> 02:57:07,960
HOSPITALIZATIONS IN 100,000S IN 

3416
02:57:07,960 --> 02:57:09,520
RED COMPARED TO FULLY VACCINATED

3417
02:57:09,520 --> 02:57:11,280
IN DARK BLUE AND FULLY 

3418
02:57:11,280 --> 02:57:13,520
VACCINATED WITH AN ADDITIONAL 

3419
02:57:13,520 --> 02:57:23,600
BOOST.

3420
02:57:30,520 --> 02:57:34,080
THIS IS VACCINATED TO FULLY 

3421
02:57:34,080 --> 02:57:35,920
VACCINATED TO FULLY VACCINATED 

3422
02:57:35,920 --> 02:57:37,760
WITH A BOOST.

3423
02:57:37,760 --> 02:57:40,360
IF YOU LOOK AT IMPACT OF BOOSTER

3424
02:57:40,360 --> 02:57:42,120
DOSES AND FROM ANOTHER 

3425
02:57:42,120 --> 02:57:44,480
PERSPECTIVE, IF YOU LOOK AT DATA

3426
02:57:44,480 --> 02:57:46,960
FROM MARCH 2022 IN WHICH OMICRON

3427
02:57:46,960 --> 02:57:51,160
CLEARLY WAS THE PREDOMINANT 

3428
02:57:51,160 --> 02:57:52,960
VARIANT, UNVACCINATED PEOPLE 

3429
02:57:52,960 --> 02:57:56,040
AGED 18 AND OLDER HAD A 

3430
02:57:56,040 --> 02:57:59,200
FIVE-FOLD INCREASED RISK OF 

3431
02:57:59,200 --> 02:58:01,840
COVID-19 ASSOCIATED 

3432
02:58:01,840 --> 02:58:02,520
HOSPITALIZATIONS AND THOSE 12 

3433
02:58:02,520 --> 02:58:09,480
AND OLDER HAD A 17 FOLD 

3434
02:58:09,480 --> 02:58:17,120
INCREASED RISK OF THOSE DYING 

3435
02:58:17,120 --> 02:58:19,680
AND BOOST EXPAND THE ELIGIBILITY

3436
02:58:19,680 --> 02:58:22,120
FOR THE PFIZER BIONTECH TO GIVE 

3437
02:58:22,120 --> 02:58:24,080
A VACCINE BOOSTER DOSE FOR 

3438
02:58:24,080 --> 02:58:25,440
CHILDREN 5-11 YEARS OLD.

3439
02:58:25,440 --> 02:58:27,800
THIS SOMETHING WE NEED TO 

3440
02:58:27,800 --> 02:58:30,800
CONTINUE TO PUSH FOR PEOPLE TO 

3441
02:58:30,800 --> 02:58:35,440
GET CHILDREN FOR THEIR PRIMARY 

3442
02:58:35,440 --> 02:58:37,320
VACCINATION AS WELL AS FOR 

3443
02:58:37,320 --> 02:58:37,600
BOOSTERS.

3444
02:58:37,600 --> 02:58:39,440
WHAT ABOUT CONSIDERATION FOR A 

3445
02:58:39,440 --> 02:58:40,680
SECOND BOOSTER SHOT.

3446
02:58:40,680 --> 02:58:42,520
HERE'S THE DATA SUMMARIZED IN 

3447
02:58:42,520 --> 02:58:43,160
BULLET FORM.

3448
02:58:43,160 --> 02:58:45,680
THE FIRST BOOSTER RESTORES THE 

3449
02:58:45,680 --> 02:58:47,880
WANING VACCINE EFFECTIVENESS OF 

3450
02:58:47,880 --> 02:58:50,120
THE PRIMARY SERIES INCLUDING 

3451
02:58:50,120 --> 02:58:53,520
AGAINST SEVERE DISEASE AND 

3452
02:58:53,520 --> 02:58:54,320
HOSPITALIZATION AS I MENTIONED.

3453
02:58:54,320 --> 02:58:55,800
HOWEVER, THE EFFECTIVENESS OF 

3454
02:58:55,800 --> 02:58:59,240
THE FIRST BOOSTER DOSE ALSO 

3455
02:58:59,240 --> 02:59:00,960
WANES OVER TIME AND GROWING 

3456
02:59:00,960 --> 02:59:03,280
EVIDENCE INDICATES A SECOND 

3457
02:59:03,280 --> 02:59:05,800
COVID-19 VACCINE BOOSTER CAN 

3458
02:59:05,800 --> 02:59:08,040
RESTORE VACCINE EFFECTIVENESS 

3459
02:59:08,040 --> 02:59:10,400
FOR CERTAIN POPULATIONS AT LEAST

3460
02:59:10,400 --> 02:59:12,160
IN THE SHORT TERM.

3461
02:59:12,160 --> 02:59:13,440
THE DATA FROM ISRAEL CLEARLY 

3462
02:59:13,440 --> 02:59:15,360
SHOW THE BENEFIT OF THE FOURTH 

3463
02:59:15,360 --> 02:59:15,600
DOSE.

3464
02:59:15,600 --> 02:59:19,040
THESE ARE A NUMBER OF STUDIES, A

3465
02:59:19,040 --> 02:59:22,400
MILLION INDIVIDUALS 60 YEARS AND

3466
02:59:22,400 --> 02:59:26,520
OLDER THE ADDITIONAL BOOST 

3467
02:59:26,520 --> 02:59:28,640
OFFERED PROTECTION AND 

3468
02:59:28,640 --> 02:59:29,840
PROTECTION DID WANE OVER SIX 

3469
02:59:29,840 --> 02:59:32,000
MONTHS IN A STUDY FROM ISRAEL 

3470
02:59:32,000 --> 02:59:35,240
THE RELATIVELY EFFECTIVENESS OF 

3471
02:59:35,240 --> 02:59:36,200
A FOURTH VACCINE DOSE AGAIN OVER

3472
02:59:36,200 --> 02:59:42,440
A SHORTER PERIOD OF TIME SHOWED 

3473
02:59:42,440 --> 02:59:48,360
61% EFFECTIVENESS AND 72% VERSUS

3474
02:59:48,360 --> 02:59:50,560
HOSPITALIZATION, 64% VERSUS 

3475
02:59:50,560 --> 02:59:54,000
SEVERE DISEASE AND 66% IN 

3476
02:59:54,000 --> 02:59:54,720
COVID-RELATED DEATHS.

3477
02:59:54,720 --> 02:59:56,200
ANOTHER WAY OF LOOKING AT THE 

3478
02:59:56,200 --> 02:59:58,400
DATA IF YOU LOOK AT MORTALITY 

3479
02:59:58,400 --> 03:00:00,360
RATES OF ACCUMULATIVE INCIDENTS 

3480
03:00:00,360 --> 03:00:02,240
OF MORTALITY RATES AND LOOK AT 

3481
03:00:02,240 --> 03:00:04,560
THE VACCINATED GROUP WHO 

3482
03:00:04,560 --> 03:00:08,120
RECEIVED THE FIRST BOOSTER 

3483
03:00:08,120 --> 03:00:09,320
COMPARED TO THOSE WHO RECEIVED 

3484
03:00:09,320 --> 03:00:12,240
THE SECOND BOOSTER, THE FIRST 

3485
03:00:12,240 --> 03:00:14,920
BOOSTER IN BLUE, THE SECOND IN 

3486
03:00:14,920 --> 03:00:17,520
TAN OF POSITIVE IMPACT ON 

3487
03:00:17,520 --> 03:00:20,920
PREVENTING DEATHS.

3488
03:00:20,920 --> 03:00:22,480
THE CDC RECOMMENDATIONS 

3489
03:00:22,480 --> 03:00:23,800
ADDITIONAL BOOST FOR CERTAIN 

3490
03:00:23,800 --> 03:00:26,840
INDIVIDUALS 50 YEARS OF AGE OR 

3491
03:00:26,840 --> 03:00:28,200
OLDER AND THE C.D.C. 

3492
03:00:28,200 --> 03:00:29,520
STRENGTHENED THAT RECOMMENDATION

3493
03:00:29,520 --> 03:00:31,520
BY SAYING INSTEAD OF JUST 

3494
03:00:31,520 --> 03:00:33,840
ELIGIBLE FOR THE FOURTH BOOST 

3495
03:00:33,840 --> 03:00:34,880
THEY RECOMMEND THAT PEOPLE 50 

3496
03:00:34,880 --> 03:00:36,720
YEARS OF AGE OR OLDER SHOULD GET

3497
03:00:36,720 --> 03:00:37,920
THE BOOST.

3498
03:00:37,920 --> 03:00:40,760
IF YOU LOOK AT THE AGE GROUP AND

3499
03:00:40,760 --> 03:00:42,800
THE VACCINE DOSE ELIGIBILITY 

3500
03:00:42,800 --> 03:00:45,520
WITH THE ORIGINAL DOSES, THE 

3501
03:00:45,520 --> 03:00:50,720
SECOND DOSES AND THIRD AND 

3502
03:00:50,720 --> 03:00:55,080
FOURTH DOSES THIS IS WHAT WE 

3503
03:00:55,080 --> 03:00:59,800
HAVE ELIGIBLE NOW AND IT'S NOT 

3504
03:00:59,800 --> 03:01:01,200
YET ELIGIBLE 0 TO 4.

3505
03:01:01,200 --> 03:01:03,520
5 TO 11 YOU CAN GIVE THE FIRST 

3506
03:01:03,520 --> 03:01:05,520
PRIMARY SERIES WITH PFIZER THE 

3507
03:01:05,520 --> 03:01:07,880
SECOND DOSE AND A MENTIONED 

3508
03:01:07,880 --> 03:01:11,360
RECENTLY A THIRD DOSE BOOST HAS 

3509
03:01:11,360 --> 03:01:12,360
BEEN APPROVED, THE FOURTH DOSE 

3510
03:01:12,360 --> 03:01:22,440
NOT.

3511
03:01:23,640 --> 03:01:24,480
YOU CAN SEE INDIVIDUALS ARE 

3512
03:01:24,480 --> 03:01:26,760
RECOMMENDED FOR THE BOOSTERS 

3513
03:01:26,760 --> 03:01:30,280
SHOWN HERE FROM 12 TO 49 THE 

3514
03:01:30,280 --> 03:01:32,840
FOURTH DOSE IN INDIVIDUAL WHO'S 

3515
03:01:32,840 --> 03:01:34,320
ARE SEVERELY IMMUNOCOMPROMISED.

3516
03:01:34,320 --> 03:01:37,760
IN 50 OR OLDER, ALL INDIVIDUALS 

3517
03:01:37,760 --> 03:01:39,120
IN THAT GROUP HAVE RECOMMENDED 

3518
03:01:39,120 --> 03:01:41,760
TO GET ALL OF THE AVAILABLE 

3519
03:01:41,760 --> 03:01:42,360
BOOSTER SHOTS INCLUDING THE 

3520
03:01:42,360 --> 03:01:45,320
FOURTH DOSE.

3521
03:01:45,320 --> 03:01:51,680
WE'RE DOING A STUDY HERE AT 

3522
03:01:51,680 --> 03:01:53,880
NIAID OF WHAT PARTICULAR BOOSTER

3523
03:01:53,880 --> 03:01:56,080
SHOULD BE USED FOR THE FOURTH 

3524
03:01:56,080 --> 03:02:02,800
DOSE.

3525
03:02:02,800 --> 03:02:09,280
THIS LOOKS AT BIVALENT COMPARED 

3526
03:02:09,280 --> 03:02:13,400
TO USING AN OMICRON SPECIFIC, A 

3527
03:02:13,400 --> 03:02:15,440
WILD TYPE SPECIFIC OR 

3528
03:02:15,440 --> 03:02:17,800
COMBINATION OF THE BOTH AS WELL 

3529
03:02:17,800 --> 03:02:23,000
AS LOOKING AT OTHER PLATFORMS 

3530
03:02:23,000 --> 03:02:26,400
SUCH AS SOLUBLE PROTEINS WITH 

3531
03:02:26,400 --> 03:02:26,640
ADJUVANTS.

3532
03:02:26,640 --> 03:02:32,240
THOSE STUDIES ARE ONGOING RIGHT 

3533
03:02:32,240 --> 03:02:42,800
NOW AND THE POWER OF THE STUDY 

3534
03:02:44,560 --> 03:02:45,800
ISN'T ENOUGH TO GIVE US CLINICAL

3535
03:02:45,800 --> 03:02:47,560
DATA BUT WE NEED TO KNOW QUICKLY

3536
03:02:47,560 --> 03:02:50,120
WHAT THE IMMUNE BRIDGING ARE TO 

3537
03:02:50,120 --> 03:02:55,880
MAKE A DECISION AS WE APPROACH 

3538
03:02:55,880 --> 03:02:58,240
THE FALL IN WHAT WE'LL BE 

3539
03:02:58,240 --> 03:03:00,200
RECOMMENDING OR THE C.D.C. WILL 

3540
03:03:00,200 --> 03:03:02,080
BE RECOMMENDING FOR THE FOURTH 

3541
03:03:02,080 --> 03:03:02,280
DOSE.

3542
03:03:02,280 --> 03:03:04,640
LET ME CLOSE BY LOOKING AT THE 

3543
03:03:04,640 --> 03:03:08,080
FUTURE OF WHERE WE ARE NOW.

3544
03:03:08,080 --> 03:03:09,680
UNIVERSAL CORONAVIRUS VACCINES 

3545
03:03:09,680 --> 03:03:12,560
WE HAVE AN URGENT NEED FOR.

3546
03:03:12,560 --> 03:03:17,480
I ARTICULATED THAT IN A PAPER 

3547
03:03:17,480 --> 03:03:19,160
FROM DECEMBER 2021 FOR THE 

3548
03:03:19,160 --> 03:03:21,800
REASONS I'VE SHOWN YOU.

3549
03:03:21,800 --> 03:03:23,480
WE'VE HAD THREE CORONAVIRUS 

3550
03:03:23,480 --> 03:03:27,240
MAJOR DISEASE, SARS, MERS, 

3551
03:03:27,240 --> 03:03:27,520
COVID-19.

3552
03:03:27,520 --> 03:03:30,480
SINCE SEPTEMBER 2020 WE'VE HAD 

3553
03:03:30,480 --> 03:03:33,440
FIVE SARS COV2 VARIANTS EMERGING

3554
03:03:33,440 --> 03:03:36,520
FROM A SINGLE VIRUS, THE SARS 

3555
03:03:36,520 --> 03:03:36,720
COV2.

3556
03:03:36,720 --> 03:03:39,440
AND INNOVATIVE APPROACHES ARE 

3557
03:03:39,440 --> 03:03:41,480
NEEDED TO PRODUCE BROAD AND 

3558
03:03:41,480 --> 03:03:45,760
DURABLE PROTECTION AGAINST 

3559
03:03:45,760 --> 03:03:47,480
CORONAVIRUS WE KNOW ABOUT AND 

3560
03:03:47,480 --> 03:03:49,520
DON'T KNOW ABOUT YET THAT MAY BE

3561
03:03:49,520 --> 03:03:50,280
LOOKING IN THE FUTURE.

3562
03:03:50,280 --> 03:03:52,240
IF YOU LOOK AT THE PHYLOGENETIC 

3563
03:03:52,240 --> 03:03:55,960
TREE OF THE CORONAVIRUS, THE 

3564
03:03:55,960 --> 03:03:59,960
HUMAN CORONAVIRUSES HAVE A RED 

3565
03:03:59,960 --> 03:04:01,160
FONT AND IN THE YELLOW ARE ALL 

3566
03:04:01,160 --> 03:04:07,120
THE VIRUSES THAT WE NOW HAVE 

3567
03:04:07,120 --> 03:04:07,880
EXPERIENCED.

3568
03:04:07,880 --> 03:04:10,840
LET'S TAKE A LOOK AT SARS COV2, 

3569
03:04:10,840 --> 03:04:13,560
THE FIRST STAGE IS TO GET A PAN 

3570
03:04:13,560 --> 03:04:18,520
SARS COV2 THAT WILL GET ALL THE 

3571
03:04:18,520 --> 03:04:18,800
VARIANTS.

3572
03:04:18,800 --> 03:04:23,520
THE NEXT STAGE WOULD BE TO GO 

3573
03:04:23,520 --> 03:04:25,440
BEYOND THAT AND GET THE CERTAIN 

3574
03:04:25,440 --> 03:04:27,320
BAT VIRUSES THAT MAY JUMP 

3575
03:04:27,320 --> 03:04:30,000
SPECIES AS HAS BEEN THE CASE IN 

3576
03:04:30,000 --> 03:04:34,360
THE PAST AS WELL AS THE VIRUS 

3577
03:04:34,360 --> 03:04:37,640
THAT CAUSED SARS COV1 AND THE 

3578
03:04:37,640 --> 03:04:39,600
PAN BETA CORONAVIRUS.

3579
03:04:39,600 --> 03:04:42,040
THE EXAMPLES OF WHERE WE ARE NOW

3580
03:04:42,040 --> 03:04:44,120
AND ALREADY DOING WE'RE USING 

3581
03:04:44,120 --> 03:04:45,440
NANO PARTICLE WITH DIFFERENT 

3582
03:04:45,440 --> 03:04:49,520
SPIKE PROTEIN FRAGMENTS GIVING 

3583
03:04:49,520 --> 03:04:50,160
DIVERSE ANTIBODY RESPONSE.

3584
03:04:50,160 --> 03:04:52,960
THERE'S STUDIES LOOKING AT 

3585
03:04:52,960 --> 03:04:54,920
INTRANASAL MIST DELIVERY OF 

3586
03:04:54,920 --> 03:04:58,520
VACCINES AS PART OF THE 

3587
03:04:58,520 --> 03:05:00,160
UNIVERSAL BETA CORONAVIRUS 

3588
03:05:00,160 --> 03:05:01,440
VACCINE CONCEPT TO GIVE MORE 

3589
03:05:01,440 --> 03:05:03,760
BROAD PROTECTION AGAINST HUMAN 

3590
03:05:03,760 --> 03:05:14,280
AND ANIMAL BETA CORONAVIRUSES.

3591
03:05:23,800 --> 03:05:24,360
AND PREPARE FOR OTHER PANDEMIC 

3592
03:05:24,360 --> 03:05:26,640
THREATS.

3593
03:05:26,640 --> 03:05:32,760
THIS IS A SCHEMATIC OF THE 

3594
03:05:32,760 --> 03:05:43,320
REPLICATION CYCLE AND ANTIVIRALS

3595
03:05:44,760 --> 03:05:46,680
WHERE WE TARGET REPLICATION 

3596
03:05:46,680 --> 03:05:47,680
CYCLES OF THE VIRUS.

3597
03:05:47,680 --> 03:05:53,120
CLOSING UP, WHAT'S THE END GAME 

3598
03:05:53,120 --> 03:05:55,480
FOR 2022 AND BEYOND, WHERE ARE 

3599
03:05:55,480 --> 03:05:59,040
WE GOING?

3600
03:05:59,040 --> 03:06:01,720
THERE'S THE ACUTE PANDEMIC PHASE

3601
03:06:01,720 --> 03:06:03,520
AND THE DECELERATION, WHICH 

3602
03:06:03,520 --> 03:06:05,360
YOU'VE EXPERIENCED AND THEN 

3603
03:06:05,360 --> 03:06:07,440
CONTROL, ELIMINATION OR 

3604
03:06:07,440 --> 03:06:07,720
ERADICATION.

3605
03:06:07,720 --> 03:06:13,080
LET'S TAKE A LOOK AT THIS.

3606
03:06:13,080 --> 03:06:15,000
WE'VE BEEN THROUGH THE FULL 

3607
03:06:15,000 --> 03:06:15,800
PANDEMIC PHASE.

3608
03:06:15,800 --> 03:06:18,880
WE'VE SEEN DECELERATION OF NEW 

3609
03:06:18,880 --> 03:06:19,080
CASES.

3610
03:06:19,080 --> 03:06:22,240
WHERE ARE WE GOING TO GO WITH 

3611
03:06:22,240 --> 03:06:22,880
THE NEXT THREE?

3612
03:06:22,880 --> 03:06:24,320
LET'S LOOK AT ERADICATION.

3613
03:06:24,320 --> 03:06:28,440
WE'RE NOT GOING TO ERADICATE THE

3614
03:06:28,440 --> 03:06:28,800
VIRUS.

3615
03:06:28,800 --> 03:06:32,080
THE ONLY VIRUS WE'VE EVER 

3616
03:06:32,080 --> 03:06:35,960
ERADICATED IS SMALLPOX AND THE 

3617
03:06:35,960 --> 03:06:39,000
REASON IS IT'S A PHENOTYPICALLY 

3618
03:06:39,000 --> 03:06:40,360
A SMALL VIRUS AND THE SMALLPOX 

3619
03:06:40,360 --> 03:06:42,880
IS THE SAME WE HAD 100 YEARS 

3620
03:06:42,880 --> 03:06:43,840
AGO.

3621
03:06:43,840 --> 03:06:45,400
WIDELY ACCEPTED GLOBAL 

3622
03:06:45,400 --> 03:06:46,240
VACCINATION CAMPAIGN WAS USED 

3623
03:06:46,240 --> 03:06:49,280
AND THE DURABILITY OF 

3624
03:06:49,280 --> 03:06:50,000
VACCINATION AND INFECTION 

3625
03:06:50,000 --> 03:06:51,520
INDUCED IMMUNITY IS VIRTUALLY 

3626
03:06:51,520 --> 03:06:51,960
LIFE LONG.

3627
03:06:51,960 --> 03:06:53,560
THAT'S WHY WE WERE ABLE TO DO 

3628
03:06:53,560 --> 03:07:02,080
THE ERADICATION OF SMALLPOX.

3629
03:07:02,080 --> 03:07:07,880
ELIMINATION OF POLIO AND MEASLES

3630
03:07:07,880 --> 03:07:13,240
THERE IS NO ANIMAL RESERVOIR AND

3631
03:07:13,240 --> 03:07:15,760
PHENOTYPICALLY STABLE AND WE 

3632
03:07:15,760 --> 03:07:17,960
HAVE FEW PHENOTYPIC CHANGES.

3633
03:07:17,960 --> 03:07:21,280
WE HAVE A WIDELY ACCEPTED 

3634
03:07:21,280 --> 03:07:22,600
NATIONAL VACCINE CAMPAIGN AND 

3635
03:07:22,600 --> 03:07:27,240
THE DURABILITY OF INFECTION 

3636
03:07:27,240 --> 03:07:29,840
INDUCED IMMUNITY IS MEASURES IN 

3637
03:07:29,840 --> 03:07:32,280
DECADES AND PERHAPS LIFE LONG.

3638
03:07:32,280 --> 03:07:34,440
WHEN WE GET TO SARS COV2 THERE'S

3639
03:07:34,440 --> 03:07:36,640
ESTABLISHED ANIMAL RESERVOIRS 

3640
03:07:36,640 --> 03:07:39,080
AND WE'VE HAD JUMPS OF 

3641
03:07:39,080 --> 03:07:42,040
CORONAVIRUS WITH SARS AND MERS 

3642
03:07:42,040 --> 03:07:45,160
AND CERTAINLY WITH SARS COV2.

3643
03:07:45,160 --> 03:07:53,520
THEN THE EVOLUTION OF 

3644
03:07:53,520 --> 03:07:55,800
PHENOTYPICALLY VARIANTS.

3645
03:07:55,800 --> 03:07:57,320
UNFORTUNATELY WE HAVE LACK OF 

3646
03:07:57,320 --> 03:08:04,120
WIDE ACCEPTANCE OF EFFECTIVE 

3647
03:08:04,120 --> 03:08:09,480
VACCINE AND THEN A FACT OF LIFE,

3648
03:08:09,480 --> 03:08:13,480
VACCINE AND INFECTION-INDUCED 

3649
03:08:13,480 --> 03:08:16,080
IMMUNITY WANES AS I'VE SHOWN YOU

3650
03:08:16,080 --> 03:08:16,520
ON SEVERAL SLIDES.

3651
03:08:16,520 --> 03:08:18,480
SO WHAT ARE WE LOOKING AT?

3652
03:08:18,480 --> 03:08:20,720
WE'RE TRYING TO CONTROL AND LIVE

3653
03:08:20,720 --> 03:08:22,960
WITH THE VIRUS AT A LOW LEVEL 

3654
03:08:22,960 --> 03:08:24,080
THAT DOES NOT DISRUPT IT.

3655
03:08:24,080 --> 03:08:25,960
SOME REFER TO THIS AS YOU LOOK 

3656
03:08:25,960 --> 03:08:27,920
AT THE RIGHT HAND PART OF THE 

3657
03:08:27,920 --> 03:08:30,600
SLIDE AS THE RETURN TO NORMALCY 

3658
03:08:30,600 --> 03:08:41,160
OR SOME REFER  REFER TO IT WITH 

3659
03:08:46,560 --> 03:08:47,720
ENDEMICITY AND THE LEVEL OF 

3660
03:08:47,720 --> 03:08:50,600
CONTROL MUST BE LOW ENOUGH TO 

3661
03:08:50,600 --> 03:08:56,800
NOT DISRUPT US AND CREATE SUCH A

3662
03:08:56,800 --> 03:09:02,320
DEGREE OF MORBIDITY AND 

3663
03:09:02,320 --> 03:09:02,840
MORTALITY.

3664
03:09:02,840 --> 03:09:03,560
WE'LL REQUIRE VACCINATION 

3665
03:09:03,560 --> 03:09:05,520
BECAUSE OF THE REASONS I'VE 

3666
03:09:05,520 --> 03:09:07,040
ARTICULATED THROUGHOUT THE TALK 

3667
03:09:07,040 --> 03:09:08,840
INCLUDING AND PARTICULARLY THE 

3668
03:09:08,840 --> 03:09:09,800
WANING IMMUNITY.

3669
03:09:09,800 --> 03:09:12,720
WE WANT TO GET BETTER VACCINES 

3670
03:09:12,720 --> 03:09:14,800
OBVIOUSLY THAT GIVE US A GREATER

3671
03:09:14,800 --> 03:09:17,440
DURABILITY OF IMMUNITY AND A 

3672
03:09:17,440 --> 03:09:20,040
GREATER BREADTH.

3673
03:09:20,040 --> 03:09:24,880
WE'LL ALSO HAVE TO USE COMMON 

3674
03:09:24,880 --> 03:09:29,120
SENSE APPROACHES LIKE VOLUNTARY 

3675
03:09:29,120 --> 03:09:30,880
MASKING WHERE APPROPRIATE AND 

3676
03:09:30,880 --> 03:09:34,440
ATTENTION TO BETTER VENTILATION 

3677
03:09:34,440 --> 03:09:36,880
AND THE FORM OF ANTIVIRALS AND 

3678
03:09:36,880 --> 03:09:37,400
MONOCLONAL ANTIBODIES.

3679
03:09:37,400 --> 03:09:39,200
WE CAN GET THERE.

3680
03:09:39,200 --> 03:09:44,600
THIS WILL NOT LAST FOREVER BUT 

3681
03:09:44,600 --> 03:09:54,960
WE'LL HAVE TO LEARNED.

3682
03:10:15,000 --> 03:10:15,840
I'VE TALKED ABOUT THE CHALLENGE 

3683
03:10:15,840 --> 03:10:17,720
OF EMERGING INFECTIONS.

3684
03:10:17,720 --> 03:10:19,040
IT'S CLEAR WE'VE ALWAYS HAD 

3685
03:10:19,040 --> 03:10:20,760
OUTBREAKS OF PANDEMICS.

3686
03:10:20,760 --> 03:10:22,520
WE'RE IN THE MIDDLE OF A 

3687
03:10:22,520 --> 03:10:25,800
HISTORIC ONE NOW AND THERE WILL 

3688
03:10:25,800 --> 03:10:28,520
BE FUTURE ONES THEREFORE WE MUST

3689
03:10:28,520 --> 03:10:29,800
LEARN LESSONS FROM THE 

3690
03:10:29,800 --> 03:10:32,720
SCIENTIFIC PREPAREDNESS WHICH 

3691
03:10:32,720 --> 03:10:35,040
HAS BEEN QUITE SUCCESSFUL AS 

3692
03:10:35,040 --> 03:10:37,080
WELL AS A MUCH BETTER PUBLIC 

3693
03:10:37,080 --> 03:10:39,000
HEALTH PREPAREDNESS AS WE LOOK 

3694
03:10:39,000 --> 03:10:42,600
FORWARD TO COOPERATING WITH 

3695
03:10:42,600 --> 03:10:43,960
OTHER COUNTRIES IN THE WORLD TO 

3696
03:10:43,960 --> 03:10:45,920
USE THE LESSONS WE LEARNED TO 

3697
03:10:45,920 --> 03:10:46,800
PREVENT THIS FROM EVER HAPPENING

3698
03:10:46,800 --> 03:10:47,000
AGAIN.

3699
03:10:47,000 --> 03:10:57,200
THANK YOU.

3700
03:11:00,920 --> 03:11:04,960
>> WE HAVE A QUEUE OF
QUESTIONS 

3701
03:11:04,960 --> 03:11:15,280
PEOPLE SEND TO ME.

3702
03:11:17,800 --> 03:11:20,120
>> THANK YOU FOR YOUR
HEROIC 

3703
03:11:20,120 --> 03:11:22,840
EFFORTS ON BEHALF OF THE 

3704
03:11:22,840 --> 03:11:24,560
AMERICAN PEOPLE AND PEOPLE 

3705
03:11:24,560 --> 03:11:24,840
WORLDWIDE.

3706
03:11:24,840 --> 03:11:26,880
I'M CONCERNED ABOUT THE GREATER 

3707
03:11:26,880 --> 03:11:32,920
IMPACT OF COVID ON OUR NATIVE 

3708
03:11:32,920 --> 03:11:38,960
AMERICAN POPULATIONS AND WONDER 

3709
03:11:38,960 --> 03:11:41,480
WHAT THE POTENTIAL OF AN ARPA-H 

3710
03:11:41,480 --> 03:11:47,000
EFFORTS THAT TARGETS THESE UNDER

3711
03:11:47,000 --> 03:11:52,960
SERVED POPULATIONS.

3712
03:11:52,960 --> 03:12:03,320
>> YOU'RE BREAKING UP.

3713
03:12:06,400 --> 03:12:10,960
>> ROBERTA, THERE'S A
SPECIFIC 

3714
03:12:10,960 --> 03:12:16,440
COMPONENT OF THE HHS EFFORT TO 

3715
03:12:16,440 --> 03:12:21,720
ADDRESS NATIVE AMERICANS AND 

3716
03:12:21,720 --> 03:12:27,000
ALASKAN NATIVE AND PACIFIC 

3717
03:12:27,000 --> 03:12:27,240
ISLANDERS.

3718
03:12:27,240 --> 03:12:31,200
THAT'S SOMETHING WE HAVE A TASK 

3719
03:12:31,200 --> 03:12:32,560
FORCE IN THE DEPARTMENT AND 

3720
03:12:32,560 --> 03:12:34,680
STARTED FROM THE BEGINNING.

3721
03:12:34,680 --> 03:12:39,880
CAMERON WEBB IS NOW THE PERSON 

3722
03:12:39,880 --> 03:12:47,720
IN THE DEPARTMENT RESPONSIBLE 

3723
03:12:47,720 --> 03:12:49,240
FOR THAT AND IT IS BEING 

3724
03:12:49,240 --> 03:12:49,520
ADDRESSED.

3725
03:12:49,520 --> 03:12:52,160
I'M NOT SURE WE NEED AN ARPA-H 

3726
03:12:52,160 --> 03:12:54,680
FOR IT, WHATEVER THAT IS BUT WE 

3727
03:12:54,680 --> 03:12:59,480
ARE ADDRESSING IT.

3728
03:12:59,480 --> 03:13:02,400
>> THANK YOU.

3729
03:13:02,400 --> 03:13:08,400
THE TECHNOLOGICAL ISSUE, THE 

3730
03:13:08,400 --> 03:13:15,120
INTRANASAL POTENTIAL IS THERE 

3731
03:13:15,120 --> 03:13:16,920
CONCERN THERE'S CROSSOVER INTO 

3732
03:13:16,920 --> 03:13:17,400
THE BRAIN?

3733
03:13:17,400 --> 03:13:24,600
IT WILL UNLIKELY BE A LIVE 

3734
03:13:24,600 --> 03:13:27,360
VACCINE AND I BELIEVE THE 

3735
03:13:27,360 --> 03:13:28,000
ATTENUATION WILL NOT HAVE 

3736
03:13:28,000 --> 03:13:30,440
REPLICATION TO ALLOW IT TO KIND 

3737
03:13:30,440 --> 03:13:31,800
OF THE DIFFICULT WE'RE STARTING 

3738
03:13:31,800 --> 03:13:35,120
TO SEE WITH OLFACTORY BULB 

3739
03:13:35,120 --> 03:13:36,840
STIMULATION AND INFLAMMATION AND

3740
03:13:36,840 --> 03:13:42,080
PERHAPS ENTRY INTO THE BRAIN.

3741
03:13:42,080 --> 03:13:43,560
THAT'S AN IMPORTANT SAFETY ISSUE

3742
03:13:43,560 --> 03:13:47,160
WHEN YOU DEAL WITH THIS 

3743
03:13:47,160 --> 03:13:48,840
EXTRAORDINARILY COMPLICATED 

3744
03:13:48,840 --> 03:13:50,320
VIRUS FOR THE FIRST TIME I'VE 

3745
03:13:50,320 --> 03:13:52,120
SEEN A VIRUS DOING THIS AND 

3746
03:13:52,120 --> 03:13:53,840
THERE'S RECENT STUDIES SHOWING 

3747
03:13:53,840 --> 03:13:55,080
INFLAMMATORY RESPONSES AROUND 

3748
03:13:55,080 --> 03:14:00,960
THE OLFACTORY BULB WHICH IS 

3749
03:14:00,960 --> 03:14:01,240
WORRISOME.

3750
03:14:01,240 --> 03:14:02,920
YOUR CONCERN IS WELL TAKEN AND 

3751
03:14:02,920 --> 03:14:13,360
WILL BE A SAFETY CONCERN.

3752
03:14:21,720 --> 03:14:24,800
>> I'VE HEARD OF THE
REBOUND TO 

3753
03:14:24,800 --> 03:14:29,800
PAXLOVID INFECTION AND WHETHER 

3754
03:14:29,800 --> 03:14:40,000
IT'S COMMON.

3755
03:14:47,680 --> 03:14:50,000
>> IT'S A CONCERN AND WHAT

3756
03:14:50,000 --> 03:14:53,600
PFIZER DID WAS DURING THE DELTA 

3757
03:14:53,600 --> 03:14:56,440
ERA IF YOU LOOK AT THE WHAT WE 

3758
03:14:56,440 --> 03:14:59,120
CALL REBOUND AND THAT MEANS 

3759
03:14:59,120 --> 03:15:01,440
SOMEONE GETS PAXLOVID, THE LEVEL

3760
03:15:01,440 --> 03:15:07,840
OF INFECTION THAT IS DETECTABLE 

3761
03:15:07,840 --> 03:15:11,360
BY ANTIGEN GOES DOWN AND 

3762
03:15:11,360 --> 03:15:13,240
SYMPTOMS RAPIDLY GO DOWN.

3763
03:15:13,240 --> 03:15:15,080
AS SOON AS THE PAXLOVID IS 

3764
03:15:15,080 --> 03:15:17,480
STOPPED HAVE YOU A REOCCURRENCE 

3765
03:15:17,480 --> 03:15:23,280
OF SYMPTOMS BUT ALSO HAVE A 

3766
03:15:23,280 --> 03:15:30,120
PROLONGATION OF THE POSITIVITY 

3767
03:15:30,120 --> 03:15:33,440
OF THE ANTIGEN TEST AND THE 90% 

3768
03:15:33,440 --> 03:15:36,200
PROTECTION AGAINST 

3769
03:15:36,200 --> 03:15:37,880
HOSPITALIZATION STILL WORKS BUT 

3770
03:15:37,880 --> 03:15:39,760
WHAT WE'RE SEEING WITH OMICRON 

3771
03:15:39,760 --> 03:15:41,960
IS AN INTERESTING PHENOMENON.

3772
03:15:41,960 --> 03:15:43,600
WE DON'T KNOW WHAT THE PERCENT 

3773
03:15:43,600 --> 03:15:44,720
IS.

3774
03:15:44,720 --> 03:15:46,400
WHEN THE PFIZER PEOPLE DID THE 

3775
03:15:46,400 --> 03:15:48,480
PLACEBO CONTROLLED STUDY THEY 

3776
03:15:48,480 --> 03:15:50,760
FOUND 2% IN THE PAXLOVID GROUP 

3777
03:15:50,760 --> 03:15:54,280
AND 1.6% WHICH WAS 

3778
03:15:54,280 --> 03:15:55,720
NON-STATISTICALLY DIFFERENT.

3779
03:15:55,720 --> 03:15:58,400
HOWEVER, WHAT WE'RE SEEING 

3780
03:15:58,400 --> 03:16:01,680
ANECDOTALLY BUT THE ANECDOTES 

3781
03:16:01,680 --> 03:16:07,120
ARE REALLY STRONG AND WHAT WE 

3782
03:16:07,120 --> 03:16:10,960
THINK IS GOING ON PEOPLE ARE 

3783
03:16:10,960 --> 03:16:13,000
GETTING PAXLOVID SO EARLY 

3784
03:16:13,000 --> 03:16:15,800
THEY'RE NOT ALLOWING THE BODY'S 

3785
03:16:15,800 --> 03:16:17,520
IMMUNE RESPONSE TO THE VIRUS 

3786
03:16:17,520 --> 03:16:21,480
KICK IN SO YOU'RE HAVING NO 

3787
03:16:21,480 --> 03:16:23,400
COMBINATION IMMUNOLOGICAL 

3788
03:16:23,400 --> 03:16:25,680
ANTIVIRAL CONTROL JUST THE 

3789
03:16:25,680 --> 03:16:26,040
VIRUS.

3790
03:16:26,040 --> 03:16:29,080
WHEN YOU PULL THE VIREO STATIC 

3791
03:16:29,080 --> 03:16:32,800
AND NOT THE VIRO STATIC DRUG 

3792
03:16:32,800 --> 03:16:35,480
AWAY THE IMMUNE SYSTEM TAKES 

3793
03:16:35,480 --> 03:16:36,960
DAYS TO CATCH UP AND SUPPRESS 

3794
03:16:36,960 --> 03:16:38,120
THE VIRUS.

3795
03:16:38,120 --> 03:16:39,320
THIS IS PURELY SPECULATION -- I 

3796
03:16:39,320 --> 03:16:41,800
DON'T WANT TO SAY IT'S STANDARD.

3797
03:16:41,800 --> 03:16:43,640
THE SPECULATION IS PEOPLE WOULD 

3798
03:16:43,640 --> 03:16:46,960
WAIT A DAY OR TWO BEFORE THEY 

3799
03:16:46,960 --> 03:16:49,400
START THE PAXLOVID YOU MAY GIVE 

3800
03:16:49,400 --> 03:16:52,960
THE IMMUNE SYSTEM A CHANCE TO 

3801
03:16:52,960 --> 03:16:55,960
REV UP IN RESPONSE TO THE VIRAL 

3802
03:16:55,960 --> 03:16:59,240
ANTIGEN SO WHEN YOU TAKE IT YOU 

3803
03:16:59,240 --> 03:17:01,440
HAVE A CONTINUATION OF THE 

3804
03:17:01,440 --> 03:17:03,080
IMMUNE RESPONSE.

3805
03:17:03,080 --> 03:17:03,960
THAT'S THE THOUGHT.

3806
03:17:03,960 --> 03:17:04,800
>> THANK YOU.

3807
03:17:04,800 --> 03:17:05,880
I SEE.

3808
03:17:05,880 --> 03:17:08,360
>> TONY MAYBE THIS IS THE
LAST 

3809
03:17:08,360 --> 03:17:11,280
WORD BECAUSE I KNOW YOU HAVE TO 

3810
03:17:11,280 --> 03:17:12,720
RUN.

3811
03:17:12,720 --> 03:17:15,360
WITH THE NASAL EARLY VACCINE, IS

3812
03:17:15,360 --> 03:17:17,160
THERE ENOUGH FUNDING AVAILABLE 

3813
03:17:17,160 --> 03:17:20,000
TO PROPEL PROMISING CANDIDATES 

3814
03:17:20,000 --> 03:17:23,120
FORWARD AND IN A TIMELY WAY?

3815
03:17:23,120 --> 03:17:25,760
>> LARRY, MAY BE YOU
ADDRESSED 

3816
03:17:25,760 --> 03:17:28,760
THAT IN YOUR OPENING REMARKS BUT

3817
03:17:28,760 --> 03:17:31,040
THAT'S AN EASY ANSWER, NO.

3818
03:17:31,040 --> 03:17:32,360
>> I WAS AFRAID THAT WAS
THE 

3819
03:17:32,360 --> 03:17:41,360
ANSWER.

3820
03:17:41,360 --> 03:17:42,920
WHEN YOU HEAR LARRY AND YOU WILL

3821
03:17:42,920 --> 03:17:45,080
OF US TALKING ABOUT WE'RE NOT 

3822
03:17:45,080 --> 03:17:50,760
KIDDING, WE DO NOT HAVE ENOUGH 

3823
03:17:50,760 --> 03:18:01,360
MONEY ALL THE MONEY IS ON 

3824
03:18:01,360 --> 03:18:04,240
VACCINES AND TESTS AND ALL 

3825
03:18:04,240 --> 03:18:06,240
IMPLEMENTATION AND NOT RESEARCH.

3826
03:18:06,240 --> 03:18:08,360
>> I WANTED YOU TO SAY IT
LOUD 

3827
03:18:08,360 --> 03:18:18,720
AND CLEAR RIGHT HERE.

3828
03:18:39,400 --> 03:18:41,920
>> HOWARD IS ASKING IF
THERE'S 

3829
03:18:41,920 --> 03:18:43,000
CONCERN FOR IMMUNE EXHAUSTION?

3830
03:18:43,000 --> 03:18:48,920
>> YES TO THE FIRST
QUESTION, IT

3831
03:18:48,920 --> 03:18:54,000
IS IN THE FUTURE.

3832
03:18:54,000 --> 03:18:55,600
GIVEN THE INEVITABLE WANING OF 

3833
03:18:55,600 --> 03:18:57,720
IMMUNITY AS WE SEE WITH THE 

3834
03:18:57,720 --> 03:18:58,960
NATURAL INFECTION WITH 

3835
03:18:58,960 --> 03:19:00,520
CORONAVIRUS, WE DO NOT BELIEVE 

3836
03:19:00,520 --> 03:19:03,320
THERE'S ANY IMMUNOLOGICAL BASIS 

3837
03:19:03,320 --> 03:19:08,000
TO THINK THERE'S GOING TO BE 

3838
03:19:08,000 --> 03:19:09,120
IMMUNE EXHAUSTION BECAUSE THE 

3839
03:19:09,120 --> 03:19:10,040
IMMUNITY DOES WANE.

3840
03:19:10,040 --> 03:19:12,960
IT'S AS IF YOU'RE DEALING WITH A

3841
03:19:12,960 --> 03:19:16,080
FUNDAMENTALLY NAIVE HOST WHEN 

3842
03:19:16,080 --> 03:19:19,520
THE IMMUNITY WANES SO LOW AFTER 

3843
03:19:19,520 --> 03:19:20,200
A WHILE.

3844
03:19:20,200 --> 03:19:25,680
>> I'M NOT SEEING OTHER 

3845
03:19:25,680 --> 03:19:31,160
QUESTIONS.

3846
03:19:31,160 --> 03:19:32,120
>> NO.

3847
03:19:32,120 --> 03:19:33,920
>> THANK YOU.

3848
03:19:33,920 --> 03:19:36,600
>> GOOD TO BE WITH YOU.

3849
03:19:36,600 --> 03:19:39,960
BYE-BYE.

3850
03:19:39,960 --> 03:19:43,640
>> WE'RE ON TIME.

3851
03:19:43,640 --> 03:19:54,160
NEXT UP IS WALTER KOROSHETZ WHO 

3852
03:19:56,960 --> 03:20:01,520
WILL BE DISCUSSING THE RECOVER 

3853
03:20:01,520 --> 03:20:05,000
EFFORT INVOLVED WITH POST-ACUTE 

3854
03:20:05,000 --> 03:20:06,480
SEQUELAE OF SARS COV2 

3855
03:20:06,480 --> 03:20:06,760
INFECTIONS.

3856
03:20:06,760 --> 03:20:11,520
THE FLOOR IS YOURS.

3857
03:20:11,520 --> 03:20:21,760
>> THANK YOU.

3858
03:20:24,160 --> 03:20:27,120
I'LL TALK ABOUT HOW PERSISTENT 

3859
03:20:27,120 --> 03:20:29,080
IT CAN BE IN SOME PEOPLE 

3860
03:20:29,080 --> 03:20:29,520
AFFECTED.

3861
03:20:29,520 --> 03:20:30,840
SO THERE'S QUITE A BIT OF DATA 

3862
03:20:30,840 --> 03:20:33,000
OUT THERE LOOKING AT DIFFERENT 

3863
03:20:33,000 --> 03:20:37,520
TYPES OF POPULATIONS OVER 

3864
03:20:37,520 --> 03:20:40,080
DIFFERENT PERIODSI OF TIME.

3865
03:20:40,080 --> 03:20:43,360
ALL SHOW PEOPLE INFECTED WITH 

3866
03:20:43,360 --> 03:20:46,960
COVID A SIGNIFICANT PROPORTION 

3867
03:20:46,960 --> 03:20:48,160
WILL DEVELOP PERSISTENT TROUBLE 

3868
03:20:48,160 --> 03:20:50,640
THAT GOES OUT A COUPLE MONTHS, 

3869
03:20:50,640 --> 03:20:52,240
THIS ONE'S AT SIX MONTHS AND 

3870
03:20:52,240 --> 03:20:53,800
PEOPLE HAVE BEEN HOSPITALIZED 

3871
03:20:53,800 --> 03:21:00,480
AND UNFORTUNATELY WE ALSO KNOW 

3872
03:21:00,480 --> 03:21:01,880
PEOPLE HAVING PERSISTENT TROUBLE

3873
03:21:01,880 --> 03:21:02,520
THAT DATES TO THE TIME OF THEIR 

3874
03:21:02,520 --> 03:21:08,400
INFECTION.

3875
03:21:08,400 --> 03:21:11,640
THE PROBLEMS FIT INTO MULTIPLE 

3876
03:21:11,640 --> 03:21:16,920
DIFFERENT CATEGORIES AND ON THE 

3877
03:21:16,920 --> 03:21:25,360
NEXT ONE SHOWS MOST PEOPLE HAVE 

3878
03:21:25,360 --> 03:21:27,000
MORE THAN ONE SYMPTOM THEY OCCUR

3879
03:21:27,000 --> 03:21:30,240
IN CLUSTERS.

3880
03:21:30,240 --> 03:21:31,680
NOT SURE IF THEY INDICATE 

3881
03:21:31,680 --> 03:21:36,920
CERTAIN GROUPS OR 

3882
03:21:36,920 --> 03:21:39,440
PATHOPHYSIOLOGIES BUT THERE'S 

3883
03:21:39,440 --> 03:21:40,480
REAL INFORMATION THAT INDICATES 

3884
03:21:40,480 --> 03:21:43,920
IT'S NOT ONE THING AND SOME ARE 

3885
03:21:43,920 --> 03:21:45,560
DUE TO SAY TISSUE DAMAGE DURING 

3886
03:21:45,560 --> 03:21:47,680
THE ACUTE INFECTION AND OTHERS 

3887
03:21:47,680 --> 03:21:51,160
ARE MORE OF A HISTORY AND FALL 

3888
03:21:51,160 --> 03:21:53,080
INTO CATEGORIES HEAVILY 

3889
03:21:53,080 --> 03:21:56,120
DOMINATED BY FATIGUE, TROUBLE 

3890
03:21:56,120 --> 03:22:02,520
WITH CONCENTRATION AND PAIN, 

3891
03:22:02,520 --> 03:22:05,040
COUGH, ABDOMINAL TROUBLE AND A 

3892
03:22:05,040 --> 03:22:06,240
LOT OF THESE OVERLAP WITH WHAT 

3893
03:22:06,240 --> 03:22:10,920
WE'VE SEEN IN THE PAST THAT GOES

3894
03:22:10,920 --> 03:22:18,680
UNDER THE TERM CHRONIC FATIGUE 

3895
03:22:18,680 --> 03:22:29,240
SYNDROME AND STUDIED WE GET THE 

3896
03:22:29,680 --> 03:22:33,480
STUDY IT STARTED AFTER AN 

3897
03:22:33,480 --> 03:22:34,560
ILLNESS AND UNFORTUNATELY THIS 

3898
03:22:34,560 --> 03:22:37,480
CONDITION KNOWN AS LONG COVID 

3899
03:22:37,480 --> 03:22:47,920
HAS A LOT OF SIMILARITIES.

3900
03:22:51,480 --> 03:22:53,480
>> THIS IS HEALTH RECORD
DATA 

3901
03:22:53,480 --> 03:22:56,080
WHERE MOST DATA IS COMING FROM 

3902
03:22:56,080 --> 03:22:58,400
AND 30 DAYS AFTER INFECTION, 

3903
03:22:58,400 --> 03:22:59,800
HOSPITALIZATION STATUS IS NOT 

3904
03:22:59,800 --> 03:23:03,400
DEFINED BIT YOU SUSPECT IT'S 

3905
03:23:03,400 --> 03:23:04,560
MORE GOING TO BE 

3906
03:23:04,560 --> 03:23:05,560
NON-HOSPITALIZED PEOPLE BECAUSE 

3907
03:23:05,560 --> 03:23:08,160
THOSE ARE THE MOST COMMON.

3908
03:23:08,160 --> 03:23:10,280
38% OF PREVIOUSLY INFECTED 

3909
03:23:10,280 --> 03:23:12,480
INDIVIDUALS HAVE ONE OF THE 

3910
03:23:12,480 --> 03:23:14,160
INCIDENT CONDITIONS YOU SEE HERE

3911
03:23:14,160 --> 03:23:19,440
AT ABOUT A MONTH OUT.

3912
03:23:19,440 --> 03:23:24,120
THE CONCLUSION IS 1 OF 5 

3913
03:23:24,120 --> 03:23:27,320
COVID-19 SURVIVES LESS THAN 65 

3914
03:23:27,320 --> 03:23:29,880
BUT GREATER THAN 16 MAY DEVELOP 

3915
03:23:29,880 --> 03:23:32,800
A CONDITION ATTRIBUTABLE TO 

3916
03:23:32,800 --> 03:23:35,920
COVID-19 AND 1 IN 4 FOR THOSE 

3917
03:23:35,920 --> 03:23:41,680
AGE 65.

3918
03:23:41,680 --> 03:23:46,240
SOME HAVE THROMBOLIC EVENT AND 

3919
03:23:46,240 --> 03:23:48,720
SOME RELATE TO THE LONG COVID 

3920
03:23:48,720 --> 03:23:52,920
SYSTEMS AND MUSCLE FATIGUE AND 

3921
03:23:52,920 --> 03:23:53,560
DISORDERS AND PAIN.

3922
03:23:53,560 --> 03:23:55,600
THIS IS THE DATA WE HAVE NOW 

3923
03:23:55,600 --> 03:23:56,440
FROM THE ELECTRONIC HEALTH 

3924
03:23:56,440 --> 03:24:06,600
RECORDS.

3925
03:24:11,840 --> 03:24:13,720
THE U.K. TRACKED PEOPLE WITH 

3926
03:24:13,720 --> 03:24:16,160
INFECTION AND ABOUT 3% OF PEOPLE

3927
03:24:16,160 --> 03:24:19,480
WHO AT 12 WEEKS AFTER ACUTE 

3928
03:24:19,480 --> 03:24:21,880
INFECTION ARE HAVING SYMPTOMS 

3929
03:24:21,880 --> 03:24:25,520
RELATED TO THEIR COVID AND THIS 

3930
03:24:25,520 --> 03:24:30,440
COMPARES TO 11. 7% BASED ON 

3931
03:24:30,440 --> 03:24:32,760
SELF-CLASSIFICATION OF PEOPLE.

3932
03:24:32,760 --> 03:24:34,480
PEOPLE ARE REPORTING THEY'RE 

3933
03:24:34,480 --> 03:24:37,760
JUST NOT FEELING AS WELL AS THEY

3934
03:24:37,760 --> 03:24:38,360
DID BEFORE.

3935
03:24:38,360 --> 03:24:39,600
IF YOU LOOK AT THE SYMPTOMS AND 

3936
03:24:39,600 --> 03:24:41,200
WE SHOWED YOU MANY OF THOSE AND 

3937
03:24:41,200 --> 03:24:42,600
YOU CAN SEE MANY ARE COMMON IN 

3938
03:24:42,600 --> 03:24:44,520
THE POPULATIONS SO IF YOU WANTED

3939
03:24:44,520 --> 03:24:47,280
TO LOOK AT WHAT'S RELATED TO 

3940
03:24:47,280 --> 03:24:50,120
COVID OR NOT, THERE ARE SOME 

3941
03:24:50,120 --> 03:24:50,440
CONFOUNDERS.

3942
03:24:50,440 --> 03:24:53,200
IN THE STUDY, 5% OF THE PEOPLE 

3943
03:24:53,200 --> 03:24:55,920
WITH COVID RELATED ANY OF THE 12

3944
03:24:55,920 --> 03:24:57,520
COMMON SYMPTOMS BUT THE 

3945
03:24:57,520 --> 03:24:59,720
PREVALENCE RATE IS 3.4% IN THE 

3946
03:24:59,720 --> 03:25:02,520
CONTROL GROUP WHO NEVER HAD 

3947
03:25:02,520 --> 03:25:03,640
COVID.

3948
03:25:03,640 --> 03:25:08,960
THAT'S BECAUSE OF THE COMMON 

3949
03:25:08,960 --> 03:25:11,040
NATURE OF THE SYMPTOMS.

3950
03:25:11,040 --> 03:25:13,400
WHEN YOU LOOK AT 12 WEEKS FROM 

3951
03:25:13,400 --> 03:25:15,160
INFECTION TYING IT TO THE 

3952
03:25:15,160 --> 03:25:20,120
INFECTION ITSELF, THERE'S 3% IN 

3953
03:25:20,120 --> 03:25:24,480
THE COVID COMPARED TO 3.5% IN 

3954
03:25:24,480 --> 03:25:26,920
THE CONTROL GROUP AND THE 

3955
03:25:26,920 --> 03:25:28,680
PREVALENCE IS HIGHER IN FEMALES 

3956
03:25:28,680 --> 03:25:32,400
AND THE CAVEAT IN HOSPITALIZED 

3957
03:25:32,400 --> 03:25:35,520
PATIENTS IT'S PRETTY MUCH 50/50 

3958
03:25:35,520 --> 03:25:38,360
BUT WHEN YOU GO TO 

3959
03:25:38,360 --> 03:25:39,600
NON-HOSPITALIZED PATIENTS 

3960
03:25:39,600 --> 03:25:41,200
FEMALES HAVE SLIGHT 

3961
03:25:41,200 --> 03:25:41,560
PREDOMINANCE.

3962
03:25:41,560 --> 03:25:44,680
THERE'S SIGNS PREEXISTING HEALTH

3963
03:25:44,680 --> 03:25:47,040
SEASON AND SEVERITY OF ILLNESS 

3964
03:25:47,040 --> 03:25:49,200
AND HIGH VIRAL LOAD OF INFECTION

3965
03:25:49,200 --> 03:25:49,840
PREDISPOSED PEOPLE TO DEVELOP 

3966
03:25:49,840 --> 03:26:00,080
THE SYNDROME.

3967
03:26:01,680 --> 03:26:04,960
THE C.D.C. HAS A BILLING CODE 

3968
03:26:04,960 --> 03:26:06,800
FOR THE POSTCOVID CONDITION AND 

3969
03:26:06,800 --> 03:26:09,160
THERE'S A STUDY NOW WITH THE USE

3970
03:26:09,160 --> 03:26:13,520
OF THE COVID IN A LARGE PRIVATE 

3971
03:26:13,520 --> 03:26:15,280
ELECTRONIC HEALTH RECORD DATA 

3972
03:26:15,280 --> 03:26:17,080
THAT HAD 9 MILLION PEOPLE WHO 

3973
03:26:17,080 --> 03:26:23,840
HAD COVID INFECTION.

3974
03:26:23,840 --> 03:26:27,160
IN THAT GROUP 4% HAD A DIAGNOSIS

3975
03:26:27,160 --> 03:26:31,480
BETWEEN OCTOBER 1 AND JANUARY 31

3976
03:26:31,480 --> 03:26:41,120
AND THE I.C.D. WENT LIVE AND 24%

3977
03:26:41,120 --> 03:26:44,480
DIAGNOSED WITH THE CODE WERE 

3978
03:26:44,480 --> 03:26:45,920
HOSPITALIZED.

3979
03:26:45,920 --> 03:26:51,280
75% OF THE PEOPLE POST-COVID ARE

3980
03:26:51,280 --> 03:26:52,400
NOT HOSPITALIZED AND THEY MAKE 

3981
03:26:52,400 --> 03:26:54,240
UP THE MOST THOUGH YOUR CHANCE 

3982
03:26:54,240 --> 03:27:01,920
OF GETTING A POST-COVID 

3983
03:27:01,920 --> 03:27:04,360
DIAGNOSIS IS HIGHER.

3984
03:27:04,360 --> 03:27:06,480
AND THE HOST COMMON CONDITIONS 

3985
03:27:06,480 --> 03:27:08,880
ASSOCIATED WITH THE ICD CODE 

3986
03:27:08,880 --> 03:27:11,560
WERE BREATHING ABNORMALITIES AND

3987
03:27:11,560 --> 03:27:16,280
COUGH IN 19% AND MALAISE AND 

3988
03:27:16,280 --> 03:27:20,480
FATIGUE IN 15.7% AND DIAGNOSIS 

3989
03:27:20,480 --> 03:27:27,760
OF UNSPECIFIED MYOPATHY AND 

3990
03:27:27,760 --> 03:27:30,400
CORONARY EMBOLISM AND THIS GIVES

3991
03:27:30,400 --> 03:27:40,920
A GLIMPSE TO WHAT WE'RE SEEING.

3992
03:27:43,880 --> 03:27:45,080
PERCENTAGE WISE THIS WILL BE A 

3993
03:27:45,080 --> 03:27:46,520
LARGE NUMBER AND THE PRESIDENT 

3994
03:27:46,520 --> 03:27:50,640
IN APRIL ANNOUNCED HE WANTS ALL 

3995
03:27:50,640 --> 03:27:55,960
THE AGENCY TO COME TOGETHER AND 

3996
03:27:55,960 --> 03:27:58,040
DEVELOP A NATIONAL PLAN FOR 

3997
03:27:58,040 --> 03:27:59,760
ADDRESSING THE LONG-TERM EFFECTS

3998
03:27:59,760 --> 03:28:01,520
AND MANY HAVE BEEN BUSY WORKING 

3999
03:28:01,520 --> 03:28:04,440
WITH THE AGENCIES ON A RESPONSE 

4000
03:28:04,440 --> 03:28:06,840
THAT COVERS NOT ONLY RESEARCH 

4001
03:28:06,840 --> 03:28:08,680
SIDE AND BIOLOGY SIDE AND THINGS

4002
03:28:08,680 --> 03:28:11,640
THAT GO INTO CARE AND FINANCES 

4003
03:28:11,640 --> 03:28:12,640
AND EVEN THE DEPARTMENT OF LABOR

4004
03:28:12,640 --> 03:28:17,520
IN TERMS OF THE EFFECTS LABOR 

4005
03:28:17,520 --> 03:28:24,800
POOL IN THE COUNTRY.

4006
03:28:24,800 --> 03:28:26,000
WHAT'S CAUSING THIS?

4007
03:28:26,000 --> 03:28:27,920
THERE'S BEEN LOTS OF REPORT BUT 

4008
03:28:27,920 --> 03:28:32,960
NOTHING REALLY ABLE TO STICK 

4009
03:28:32,960 --> 03:28:33,360
OVER TIME.

4010
03:28:33,360 --> 03:28:35,160
THERE'S NO TREATMENTS WE'VE BEEN

4011
03:28:35,160 --> 03:28:36,840
ABLE TO DISCOVER FOR THE CASES 

4012
03:28:36,840 --> 03:28:41,880
WHICH WE THINK ARE CHRONIC 

4013
03:28:41,880 --> 03:28:45,320
DISEASES AST INFECTION.

4014
03:28:45,320 --> 03:28:48,640
THERE'S LOTS OF PEOPLE LOOKING 

4015
03:28:48,640 --> 03:28:50,520
AT THIS AND REPORTS IN THE 

4016
03:28:50,520 --> 03:28:55,920
LITERATURE AND THIS IS ONE THAT 

4017
03:28:55,920 --> 03:28:59,160
IS SHOWING IG3 LEVELS USUALLY GO

4018
03:28:59,160 --> 03:29:02,360
UP IN ACUTE COVID AND PEOPLE WHO

4019
03:29:02,360 --> 03:29:06,240
DEVELOP THE LONG COVID WERE 

4020
03:29:06,240 --> 03:29:08,760
LIKELY TO HAVE LOW LEVELS OF IG3

4021
03:29:08,760 --> 03:29:10,640
DURING THEIR ACUTE INFECTION.

4022
03:29:10,640 --> 03:29:16,960
AGAIN, THE NUMBERS OF PEOPLE 

4023
03:29:16,960 --> 03:29:23,760
HERE IN THE LOW HUNDREDS THIS 

4024
03:29:23,760 --> 03:29:28,840
LOOKS AT HOW GERMANY WHERE THEY 

4025
03:29:28,840 --> 03:29:31,880
HAD A POPULATION STUDY AND THEY 

4026
03:29:31,880 --> 03:29:33,960
LOOKED AT AUTOANTIBODIES AND WE 

4027
03:29:33,960 --> 03:29:35,720
SEE THEM COMMONLY IN PEOPLE 

4028
03:29:35,720 --> 03:29:37,920
AFTER COVID-19 BUT NO DIFFERENCE

4029
03:29:37,920 --> 03:29:40,440
WHETHER YOU HAVE POST-ACUTE 

4030
03:29:40,440 --> 03:29:49,320
SEQUELAE OF COVID OR NOT.

4031
03:29:49,320 --> 03:29:53,040
THEY SEE IN INCREASE IN IL6 

4032
03:29:53,040 --> 03:29:56,080
LEVELS IN THOSE WHO HAVE 

4033
03:29:56,080 --> 03:30:06,560
POST-ACUTE SEQUELAE OF COVID.

4034
03:30:21,640 --> 03:30:23,760
THIS LOOKS AT WHETHER THE VIRUS 

4035
03:30:23,760 --> 03:30:25,120
IS PERSISTENT IN PEOPLE AFTER 

4036
03:30:25,120 --> 03:30:26,080
INFECTION.

4037
03:30:26,080 --> 03:30:29,080
THERE'S HUNDREDS OF VIRUSES WE 

4038
03:30:29,080 --> 03:30:30,680
BECOME INFECTED WITH AND MANY 

4039
03:30:30,680 --> 03:30:31,960
ARE RESIDENT IN OUR BODIES IN 

4040
03:30:31,960 --> 03:30:40,600
SOME FASHION.

4041
03:30:40,600 --> 03:30:44,400
ZOSTER AND ABV ARE SOME 

4042
03:30:44,400 --> 03:30:44,720
EXAMPLES.

4043
03:30:44,720 --> 03:30:46,520
THE QUESTION IS THERE VIRAL 

4044
03:30:46,520 --> 03:30:47,880
PERSISTENCE THAT STIMULATES THE 

4045
03:30:47,880 --> 03:30:50,840
IMMUNE SYSTEM TO CAUSE THE 

4046
03:30:50,840 --> 03:30:53,440
SYSTEMS WHICH SOUND LIKE THE 

4047
03:30:53,440 --> 03:30:54,760
KIND OF SYSTEMS YOU DEVELOP WITH

4048
03:30:54,760 --> 03:30:56,880
AN ACUTE INFECTION THAT PERSIST 

4049
03:30:56,880 --> 03:30:57,840
OVER TIME.

4050
03:30:57,840 --> 03:31:00,880
THIS IS A PAPER THAT IS IN PRE 

4051
03:31:00,880 --> 03:31:05,520
PRINT STAGE FROM THE NCI.

4052
03:31:05,520 --> 03:31:11,640
I THINK IT WAS 44 AUTOPSIES BUT 

4053
03:31:11,640 --> 03:31:16,520
80% WERE PEOPLE ON RESPIRATORS 

4054
03:31:16,520 --> 03:31:18,520
AND WERE EXPECTING TO SEE 

4055
03:31:18,520 --> 03:31:20,760
MULTIPLE REPLICATION IN TISSUES 

4056
03:31:20,760 --> 03:31:23,600
THOUGH PEOPLE DIED 230 DAYS 

4057
03:31:23,600 --> 03:31:27,080
AFTER SYMPTOM ON SET.

4058
03:31:27,080 --> 03:31:31,000
THE COPY NUMBER IS LOW IN THE 

4059
03:31:31,000 --> 03:31:31,520
TISSUES.

4060
03:31:31,520 --> 03:31:32,880
THIS IS GOING TO BE A BIG 

4061
03:31:32,880 --> 03:31:34,640
QUESTION FOR US IN UNDERSTANDING

4062
03:31:34,640 --> 03:31:35,960
PERSISTENT INFECTION AND IF 

4063
03:31:35,960 --> 03:31:38,520
THAT'S THE CASE, IS IT THE CAUSE

4064
03:31:38,520 --> 03:31:41,720
OF THE SYMPTOMS THAT PEOPLE ARE 

4065
03:31:41,720 --> 03:31:43,280
EXHIBITING AND WHETHER AN 

4066
03:31:43,280 --> 03:31:44,360
ANTIVIRAL CAN SOLVE SOME OF THE 

4067
03:31:44,360 --> 03:31:54,480
PROBLEM.

4068
03:31:58,080 --> 03:31:59,800
WE'RE SEEING LOTS OF STUDIES AND

4069
03:31:59,800 --> 03:32:02,840
WE PUT TOGETHER THE RECOVER 

4070
03:32:02,840 --> 03:32:04,640
INITIATIVE ENGINEERED TO NOT 

4071
03:32:04,640 --> 03:32:09,560
LEAVE ANY STONE UNTURNED AND 

4072
03:32:09,560 --> 03:32:10,800
LOOK UNDER EVERY CORNER FOR WHAT

4073
03:32:10,800 --> 03:32:12,680
COULD BE CAUSING THE TROUBLE TO 

4074
03:32:12,680 --> 03:32:15,000
MAKE SURE WHEN DISCOVERIES ARE 

4075
03:32:15,000 --> 03:32:16,760
ANNOUNCED THEY COULD BE 

4076
03:32:16,760 --> 03:32:18,520
VALIDATED SO WE KNOW WHAT STICKS

4077
03:32:18,520 --> 03:32:20,760
OVER TIME AND MOVE FROM 

4078
03:32:20,760 --> 03:32:25,640
DISCOVERY TOWARDS TREATMENT.

4079
03:32:25,640 --> 03:32:26,800
THAT'S THE GOAL OF THE 

4080
03:32:26,800 --> 03:32:28,280
INITIATIVE AND THE IDEA IS THE 

4081
03:32:28,280 --> 03:32:30,080
ANSWER PLAY NOT BE EASY TAKEN 

4082
03:32:30,080 --> 03:32:32,800
FROM THE LESSONS WE HAVE WITH 

4083
03:32:32,800 --> 03:32:35,440
THE OTHER POSTINFECTIOUS 

4084
03:32:35,440 --> 03:32:36,840
CONDITIONS THAT COST PERSISTENT 

4085
03:32:36,840 --> 03:32:46,000
TROUBLE IN PEOPLE.

4086
03:32:46,000 --> 03:32:49,040
THIS IS LED BY NHLBI AND GARY 

4087
03:32:49,040 --> 03:32:51,520
GIBBONS IS THE HEAD AND AMY 

4088
03:32:51,520 --> 03:32:53,520
PATTERSON IS THE EISENHOWER OF 

4089
03:32:53,520 --> 03:32:54,440
THE PROJECT AND WE'VE WORKED 

4090
03:32:54,440 --> 03:32:55,560
TOGETHER A LONG TIME NOW.

4091
03:32:55,560 --> 03:32:57,320
WE STARTED OUT WITH LISTENING 

4092
03:32:57,320 --> 03:33:02,400
SESSIONS WHERE WE WOULD GET IN 

4093
03:33:02,400 --> 03:33:07,800
THE EVENING WITH DOCS RUNNING 

4094
03:33:07,800 --> 03:33:10,560
THE POSTCOVID CLINIC AND HAD 

4095
03:33:10,560 --> 03:33:12,800
LISTENING SESSIONS AND KEPT OUR 

4096
03:33:12,800 --> 03:33:15,560
EARS OPEN AND GOT INPUT FROM ALL

4097
03:33:15,560 --> 03:33:16,360
SECTORS, PARTICULARLY PEOPLE 

4098
03:33:16,360 --> 03:33:26,880
SUFFERING WITH THE CONDITION.

4099
03:33:32,120 --> 03:33:37,360
WE HAVE LAYERS OF GOVERNANCE AND

4100
03:33:37,360 --> 03:33:42,320
THERE'S COMMUNICATION WITH THE 

4101
03:33:42,320 --> 03:33:44,520
EFFORTS GOING ON OUT OF 

4102
03:33:44,520 --> 03:33:47,880
LIVERPOOL FOR OUTCOME MEASURES 

4103
03:33:47,880 --> 03:33:48,640
POST COVID.

4104
03:33:48,640 --> 03:33:54,560
WE REACHED OUT BEST WE CAN TO 

4105
03:33:54,560 --> 03:34:05,120
GET INPUT THE GOAL IS TO LOOK AT

4106
03:34:12,160 --> 03:34:18,520
THE PREVALENCE ANDFIDE THE 

4107
03:34:18,520 --> 03:34:20,800
SUBTYPES -- AND IDENTIFY THE 

4108
03:34:20,800 --> 03:34:21,920
SUBTYPES AND STUDY IT OVER TIME 

4109
03:34:21,920 --> 03:34:25,520
AND TO LOOK AT THE OTHER ORGAN 

4110
03:34:25,520 --> 03:34:29,520
SYSTEM DYSFUNCTIONS THAT COULD 

4111
03:34:29,520 --> 03:34:32,600
OCCUR 5 YEARS, 10 YEARS DOWN THE

4112
03:34:32,600 --> 03:34:35,240
ROAD DUE TO THE FACT SO MANY 

4113
03:34:35,240 --> 03:34:37,480
PEOPLE IN THE COUNTRY HAVE BEEN 

4114
03:34:37,480 --> 03:34:38,080
AFFECTED BY COVID.

4115
03:34:38,080 --> 03:34:41,160
THE GOAL IS TO TRY TO IDENTIFY 

4116
03:34:41,160 --> 03:34:44,120
THE BIOLOGY AND INTERVENE AND 

4117
03:34:44,120 --> 03:34:54,320
TREAT AND PREVENT.

4118
03:34:54,320 --> 03:34:55,800
THERE'S MULTIPLE PIECES TO THE 

4119
03:34:55,800 --> 03:34:56,160
PROGRAM.

4120
03:34:56,160 --> 03:34:58,920
THERE'S COHORTS AND ELECTRONIC 

4121
03:34:58,920 --> 03:35:05,360
HEALTH REPORT STUDIES.

4122
03:35:05,360 --> 03:35:07,760
WE ARE PUTTING TOGETHER COHORTS 

4123
03:35:07,760 --> 03:35:12,840
HOPING TO ENROLL 40,000 PEOPLE.

4124
03:35:12,840 --> 03:35:15,760
WE'RE PUTTING TOGETHER STUDIES 

4125
03:35:15,760 --> 03:35:19,080
OF ELECTRONIC HEALTH SYSTEMS AND

4126
03:35:19,080 --> 03:35:22,840
THIS IS IMPORTANT IF WE'RE GOING

4127
03:35:22,840 --> 03:35:28,840
TO LOOK 5, 10 YEARS DOWN THE 

4128
03:35:28,840 --> 03:35:31,440
ROAD LOOKING AT COVID-19 

4129
03:35:31,440 --> 03:35:33,720
INFECTION AND WE HAVE AUTOPSY 

4130
03:35:33,720 --> 03:35:40,680
STUDIES LOOKING TO RECRUIT 

4131
03:35:40,680 --> 03:35:42,920
HUNDREDS OF PERSONS WHO HAVE 

4132
03:35:42,920 --> 03:35:45,320
DIED FROM WHATEVER CONDITION BUT

4133
03:35:45,320 --> 03:35:47,800
PREVIOUSLY HAD COVID-19.

4134
03:35:47,800 --> 03:35:49,200
SOME OF WHOM HAVE PASSED AND 

4135
03:35:49,200 --> 03:35:50,880
SOME NOT TO GO AFTER WHAT WE 

4136
03:35:50,880 --> 03:35:52,080
TALKED ABOUT EARLIER THE KIND OF

4137
03:35:52,080 --> 03:35:56,080
THINGS YOU CAN ALWAYS SEE UNDER 

4138
03:35:56,080 --> 03:35:58,680
THE MICROSCOPE CAN'T REALLY GET 

4139
03:35:58,680 --> 03:36:00,880
OUT OF BLOOD OR SALIVA.

4140
03:36:00,880 --> 03:36:02,360
IF ANYTHING IS GOING TO GIVE US 

4141
03:36:02,360 --> 03:36:04,800
QUICK ANSWERS IT'S GOING TO BE 

4142
03:36:04,800 --> 03:36:07,320
THE AUTOPSY STUDIES.

4143
03:36:07,320 --> 03:36:09,920
WE'RE ALSO RIGHT NOW ARE SETTING

4144
03:36:09,920 --> 03:36:12,360
UP A PLATFORM TO DO CLINICAL 

4145
03:36:12,360 --> 03:36:18,400
TRIALS IN PEOPLE WITH POST-ACUTE

4146
03:36:18,400 --> 03:36:21,200
SEQUELAE OF COVID AND HAVE A 

4147
03:36:21,200 --> 03:36:23,560
CALL OUT OF TRIALS AND FUNDING 

4148
03:36:23,560 --> 03:36:28,400
PATHOLOGY STUDIES OF VARIOUS 

4149
03:36:28,400 --> 03:36:30,120
TYPES EITHER CLINIC OR 

4150
03:36:30,120 --> 03:36:32,560
LABORATORY TO TRY TO UNDERSTAND 

4151
03:36:32,560 --> 03:36:34,400
WHAT IS THE UNDERLYING BIOLOGY 

4152
03:36:34,400 --> 03:36:40,200
IN PEOPLE WITH PARTICULARLY WITH

4153
03:36:40,200 --> 03:36:42,800
LONG COVID.

4154
03:36:42,800 --> 03:36:46,000
NOW NOW WE HAVE A NATIONAL SCALE

4155
03:36:46,000 --> 03:36:48,120
PLATFORM WITH ADULT COHORTS AND 

4156
03:36:48,120 --> 03:36:49,240
PREGNANCY COHORTS AN EIGHT 

4157
03:36:49,240 --> 03:36:53,080
PEDIATRIC COHORTS AND FIVE 

4158
03:36:53,080 --> 03:36:53,720
AUTOPSY CENTERS.

4159
03:36:53,720 --> 03:36:58,600
WE HAVE THE HR STUDIES UP AND 

4160
03:36:58,600 --> 03:37:00,320
RUNNING ACCESSING 60 MILLION 

4161
03:37:00,320 --> 03:37:01,080
PATIENT RECORDS.

4162
03:37:01,080 --> 03:37:03,280
WE HAVE 200 SITES AROUND THE 

4163
03:37:03,280 --> 03:37:03,680
COUNTRY.

4164
03:37:03,680 --> 03:37:14,240
AS OF THIS WEEK WE HAVE ENROLLED

4165
03:37:16,560 --> 03:37:20,640
PARTICIPANTS ACROSS 58 SITES AND

4166
03:37:20,640 --> 03:37:22,480
16 PARTICIPANTS IN THE AUTOPSY 

4167
03:37:22,480 --> 03:37:28,000
COHORT.

4168
03:37:28,000 --> 03:37:29,400
IN THE COHORT THERE'S BASICALLY 

4169
03:37:29,400 --> 03:37:32,120
TWO POOLS OF PATIENTS WE'RE 

4170
03:37:32,120 --> 03:37:33,560
LOOKING FOR.

4171
03:37:33,560 --> 03:37:35,320
WE THINK THAT IT'S MOST 

4172
03:37:35,320 --> 03:37:37,400
IMPORTANT RIGHT NOW AS THE 

4173
03:37:37,400 --> 03:37:43,200
INFECTION IS STILL PROMINENT TO 

4174
03:37:43,200 --> 03:37:53,760
STUDY THE PROCESS TO STUDY THOSE

4175
03:37:55,080 --> 03:37:58,200
WHO MAKE A GOOD RECOVERY VERSUS 

4176
03:37:58,200 --> 03:37:59,440
THOSE WHO DEVELOP PERSISTENT 

4177
03:37:59,440 --> 03:37:59,720
SYMPTOMS.

4178
03:37:59,720 --> 03:38:10,240
IT'S A TIME-SENSITIVE PROJECT 

4179
03:38:13,440 --> 03:38:16,440
ONCE THE ACUTE INFECTIONS GO 

4180
03:38:16,440 --> 03:38:21,520
DOWN STUDYING PEOPLE AFTER BEING

4181
03:38:21,520 --> 03:38:26,360
INFECTION S MATCH WHO WEREN'T 

4182
03:38:26,360 --> 03:38:27,800
INFECTED AND WE LOST THE ABILITY

4183
03:38:27,800 --> 03:38:29,480
TO SEE THE EARLY STAGE PROCESS 

4184
03:38:29,480 --> 03:38:31,440
OF RECOVERY UNLESS WE CAN GET 

4185
03:38:31,440 --> 03:38:34,480
ENOUGH PEOPLE IN THE FIRST GROUP

4186
03:38:34,480 --> 03:38:44,880
TO INFORM THESE ISSUES.

4187
03:38:45,960 --> 03:38:47,480
WE'RE ALWAYS LOOKING AT PEOPLE 

4188
03:38:47,480 --> 03:38:49,880
AFTER TROUBLE AND TRYING TO LOOK

4189
03:38:49,880 --> 03:38:51,600
AT PREGNANT PERSONS IN BOTH 

4190
03:38:51,600 --> 03:38:57,160
THESE GROUPS, CHILDREN IN BOTH 

4191
03:38:57,160 --> 03:39:00,040
GROUPS AND ALSO MISC.

4192
03:39:00,040 --> 03:39:05,880
THE STUDY IS SET UP IN MULTIPLE 

4193
03:39:05,880 --> 03:39:06,400
YEARS.

4194
03:39:06,400 --> 03:39:10,080
THE FIRST YEAR IS A SURVEY OF 

4195
03:39:10,080 --> 03:39:11,640
QUESTIONS, LABORATORY BIO 

4196
03:39:11,640 --> 03:39:12,360
SPECIMENS EVERYBODY GETS.

4197
03:39:12,360 --> 03:39:18,240
WE'RE LOOKING TO DO THAT WITH 

4198
03:39:18,240 --> 03:39:18,800
17,000 PEOPLE.

4199
03:39:18,800 --> 03:39:22,800
THE NEXT YEAR IS LOW RISK 

4200
03:39:22,800 --> 03:39:23,920
CLINICAL TESTS.

4201
03:39:23,920 --> 03:39:28,120
THEY'RE LESS INVASIVE AND POISED

4202
03:39:28,120 --> 03:39:30,560
TO LOOK AT PARTICULAR PROBLEMS 

4203
03:39:30,560 --> 03:39:36,560
AND SLEEP DISORDERS OR EXERCISE 

4204
03:39:36,560 --> 03:39:38,080
WHICH ARE COMMON PROBLEMS THAT 

4205
03:39:38,080 --> 03:39:40,400
REQUIRE A DEEPER DIVE THAN IN 

4206
03:39:40,400 --> 03:39:42,600
THE TIER 1 SPACE AND GOING TO 

4207
03:39:42,600 --> 03:39:45,840
TIER 2 DEPENDS ON WHAT THE 

4208
03:39:45,840 --> 03:39:50,280
PATIENT'S PROBLEMS ARE.

4209
03:39:50,280 --> 03:39:51,880
YOU SHUN PEOPLE WITH PARTICULAR 

4210
03:39:51,880 --> 03:39:54,880
PROBLEMS AND IN TIER 2 ARE MORE 

4211
03:39:54,880 --> 03:39:56,920
ADVANCED TESTING IN THE SPECIFIC

4212
03:39:56,920 --> 03:39:57,520
AREAS.

4213
03:39:57,520 --> 03:39:59,800
WE SHOULD HAVE AND THERE'LL BE 

4214
03:39:59,800 --> 03:40:03,640
BIO SPECIMENS AT ALL THESE 

4215
03:40:03,640 --> 03:40:05,440
LEVELS AND IMAGING FOR ALL THE 

4216
03:40:05,440 --> 03:40:07,360
LEVELS AND BROUGHT INTO 

4217
03:40:07,360 --> 03:40:08,120
REPOSITORIES AVAILABLE FOR 

4218
03:40:08,120 --> 03:40:13,680
SEARCHING AND MINING.

4219
03:40:13,680 --> 03:40:18,200
AND JUST TO SAY THE PEDIATRIC 

4220
03:40:18,200 --> 03:40:21,440
COHORT IS PRETTY SIMILAR BUT 

4221
03:40:21,440 --> 03:40:25,080
ALSO HAS LOOKING AT BABIES WHO 

4222
03:40:25,080 --> 03:40:28,160
WERE EXPOSED IN UTERO AND THE 

4223
03:40:28,160 --> 03:40:29,640
MAIN COHORT THAT LOOKS LIKE THE 

4224
03:40:29,640 --> 03:40:35,720
ADULT COHORT AND BRINGING THE 

4225
03:40:35,720 --> 03:40:41,040
ABCD COHORT AND A GROUP TO LOOK 

4226
03:40:41,040 --> 03:40:45,520
AT THE MISC AND POST-VACCINATION

4227
03:40:45,520 --> 03:40:56,000
MENSTRUAL CYCLE CONDITIONS.

4228
03:40:58,160 --> 03:41:00,640
THE ENROLLMENT IS OPEN AND 

4229
03:41:00,640 --> 03:41:01,760
PEOPLE CAN PLUG IN THEIR ZIP 

4230
03:41:01,760 --> 03:41:05,480
CODE AND FIND THE CLOSEST SITE 

4231
03:41:05,480 --> 03:41:08,120
TO THEM AND CONTACT THEM TO 

4232
03:41:08,120 --> 03:41:11,800
ENROLL IN THE STUDY.

4233
03:41:11,800 --> 03:41:13,880
THE CHALLENGES ARE MOSTLY 

4234
03:41:13,880 --> 03:41:14,480
RELATED TO THE NATURE OF THE 

4235
03:41:14,480 --> 03:41:20,880
PANDEMIC.

4236
03:41:20,880 --> 03:41:23,160
ENROLLING PEOPLE IS NOT AS EASY 

4237
03:41:23,160 --> 03:41:23,440
AS THE PAST.

4238
03:41:23,440 --> 03:41:25,480
LOTS OF PEOPLE JUST TAKE THE 

4239
03:41:25,480 --> 03:41:28,000
TEST AT HOME AND DON'T TELL 

4240
03:41:28,000 --> 03:41:29,040
ANYBODY.

4241
03:41:29,040 --> 03:41:32,560
THAT'S A HURDLE WE'RE PUSHING ON

4242
03:41:32,560 --> 03:41:35,280
TO GET THAT GROUP IN.

4243
03:41:35,280 --> 03:41:38,320
ENROLLING PEOPLE WHO HAVE 

4244
03:41:38,320 --> 03:41:39,000
PERSISTENT SYMPTOMS IS QUITE 

4245
03:41:39,000 --> 03:41:40,640
EASY AT THIS POINT AND SOME OF 

4246
03:41:40,640 --> 03:41:42,920
THE SITES HAVE FILLED UP THE 

4247
03:41:42,920 --> 03:41:44,480
QUOTA IN PEOPLE WHO HAVE 

4248
03:41:44,480 --> 03:41:46,120
PERSISTENT SYMPTOMS.

4249
03:41:46,120 --> 03:41:50,960
OF COURSE, THE INFECTION'S 

4250
03:41:50,960 --> 03:42:01,480
CHANGING AND THE VARIANTS ARE 

4251
03:42:01,480 --> 03:42:03,120
CHANGE.

4252
03:42:03,120 --> 03:42:05,480
THERE'S VARIANTS THAT HAVE COULD

4253
03:42:05,480 --> 03:42:11,400
BE INCLUDED IN THE ANALYSIS.

4254
03:42:11,400 --> 03:42:18,960
THIS IS THE STUDY WE HAVE WITH P

4255
03:42:18,960 --> 03:42:20,320
CORENET WITH MORE THAN 60 

4256
03:42:20,320 --> 03:42:23,040
MILLION RECORDS AND PUBLICATIONS

4257
03:42:23,040 --> 03:42:25,960
AROUND THE SYSTEM COMPLEX AND 

4258
03:42:25,960 --> 03:42:29,320
CARDIAC COMPLICATIONS.

4259
03:42:29,320 --> 03:42:32,320
THIS TRIED TO DEVELOP THE RECORD

4260
03:42:32,320 --> 03:42:35,040
SIGNATURE OF LONG COVID AND WAS 

4261
03:42:35,040 --> 03:42:36,640
ABLE TO USE DATA FROM PATIENTS 

4262
03:42:36,640 --> 03:42:39,680
WHO GO FROM A POST-COVID 

4263
03:42:39,680 --> 03:42:44,120
CLINICAL REFINING THAT 

4264
03:42:44,120 --> 03:42:44,640
ELECTRONIC HEALTH RECORD 

4265
03:42:44,640 --> 03:42:52,760
SIGNATURE.

4266
03:42:52,760 --> 03:42:55,080
PCORNET IS DISTRIBUTED IN 

4267
03:42:55,080 --> 03:42:56,800
MULTIPLE ACADEMIC AND HEALTH 

4268
03:42:56,800 --> 03:43:07,120
CARE SYSTEMS ACROSS THE COUNTRY.

4269
03:43:07,120 --> 03:43:10,280
THIS IS A MENTION OF 

4270
03:43:10,280 --> 03:43:10,640
PATHOBIOLOGY.

4271
03:43:10,640 --> 03:43:12,960
WE HAVE A CALL OUT AND WE'RE 

4272
03:43:12,960 --> 03:43:14,480
ALMOST AT THE END OF REVIEWING 

4273
03:43:14,480 --> 03:43:16,040
AND FUNDING A NUMBER OF REALLY 

4274
03:43:16,040 --> 03:43:20,120
GOOD APPLICATIONS FOR PEOPLE WHO

4275
03:43:20,120 --> 03:43:26,120
UNDERSTAND THE CLINICAL 

4276
03:43:26,120 --> 03:43:36,640
MANIFESTATIONS OF PASC AND THIS 

4277
03:43:37,160 --> 03:43:38,440
TAKES ADVANTAGE OF PATIENTS 

4278
03:43:38,440 --> 03:43:39,640
ENROLLED AND THIS IS A 

4279
03:43:39,640 --> 03:43:40,880
SUPPLEMENT TO PEOPLE IN GRANTS 

4280
03:43:40,880 --> 03:43:42,240
THAT CAN DO RESEARCH THAT IS 

4281
03:43:42,240 --> 03:43:44,000
RELEVANT AND IMPORTANT TO 

4282
03:43:44,000 --> 03:43:45,680
UNDERSTANDING THE BIOLOGICAL 

4283
03:43:45,680 --> 03:43:47,080
MECHANISMS OF PASC.

4284
03:43:47,080 --> 03:43:49,920
THIS IS WIDE OPEN COMPETITION 

4285
03:43:49,920 --> 03:43:54,440
AND AGAIN SOME GOOD IDEAS COMING

4286
03:43:54,440 --> 03:43:54,600
IN.

4287
03:43:54,600 --> 03:43:56,120
SOME PEOPLE HAVE INTERESTING 

4288
03:43:56,120 --> 03:44:06,560
PRELIMINARY DATA AS WELL.

4289
03:44:19,720 --> 03:44:22,080
LOOKING AT THE BEST WAY TO TREAT

4290
03:44:22,080 --> 03:44:24,520
THE COUGH OR PAIN OR 

4291
03:44:24,520 --> 03:44:25,160
BREATHLESSNESS.

4292
03:44:25,160 --> 03:44:28,320
WE'D LIKE TO GET AT THE 

4293
03:44:28,320 --> 03:44:30,400
UNDERLYING BIOLOGICAL DISEASE 

4294
03:44:30,400 --> 03:44:32,120
MECHANISMS AND TREATMENT IN THAT

4295
03:44:32,120 --> 03:44:37,560
SPACE.

4296
03:44:37,560 --> 03:44:39,080
ANTIVIRALS FOR IMMUNE SYSTEM 

4297
03:44:39,080 --> 03:44:39,400
MODULATORS.

4298
03:44:39,400 --> 03:44:45,040
THAT'S GOT TO BE PRETTY MUCH 

4299
03:44:45,040 --> 03:44:46,640
DRIVEN BY WHAT WE UNDERSTAND 

4300
03:44:46,640 --> 03:44:57,160
ABOUT THE BIOLOGY ON THAT SIDE 

4301
03:44:59,400 --> 03:45:02,120
AND WE REACHED OUT TO A WIDE 

4302
03:45:02,120 --> 03:45:02,640
COMMUNITY.

4303
03:45:02,640 --> 03:45:04,080
WE'VE DONE A LANDSCAPE ANALYSIS 

4304
03:45:04,080 --> 03:45:08,360
OF WHAT'S GOING ON NOW.

4305
03:45:08,360 --> 03:45:13,480
THERE'S NOT A LARGE 

4306
03:45:13,480 --> 03:45:16,440
SCIENTIFICALLY IT'S A LITTLE 

4307
03:45:16,440 --> 03:45:25,320
WIDE OPEN AREA.

4308
03:45:25,320 --> 03:45:27,320
WE HAVE A CALL AND APPLICATIONS 

4309
03:45:27,320 --> 03:45:32,920
ARE BEING FINALIZED FOR A 

4310
03:45:32,920 --> 03:45:33,560
CLINICAL TRIAL DATA CENTER AND 

4311
03:45:33,560 --> 03:45:35,040
PARTICULAR GRANTS IN TRIALS IN 

4312
03:45:35,040 --> 03:45:36,800
THOSE OVER 18 YEARS OLD FOR THE 

4313
03:45:36,800 --> 03:45:38,120
TREATMENT OF OR PREVENTION OF 

4314
03:45:38,120 --> 03:45:48,200
PASC.

4315
03:45:50,840 --> 03:45:52,360
THERE'S AN OPPORTUNITY AND LOT 

4316
03:45:52,360 --> 03:45:57,480
OF PEOPLE ARE SUFFERING AND LOTS

4317
03:45:57,480 --> 03:45:59,080
OF FRUSTRATION BECAUSE WE DON'T 

4318
03:45:59,080 --> 03:46:00,000
KNOW MUCH ABOUT THE CONDITIONS 

4319
03:46:00,000 --> 03:46:02,480
AND HOW IT TREAT THEM AND CAUSES

4320
03:46:02,480 --> 03:46:02,960
FRUSTRATION.

4321
03:46:02,960 --> 03:46:08,120
YOU CAN'T TELL PEOPLE HOW LONG 

4322
03:46:08,120 --> 03:46:14,560
IT'S GOING TO LAST.

4323
03:46:14,560 --> 03:46:15,520
AND WE'RE LEARNING MORE ABOUT 

4324
03:46:15,520 --> 03:46:18,520
THIS AND FOCUS ON THE TREATMENTS

4325
03:46:18,520 --> 03:46:21,520
AND WE HAVE THIS UNIQUE 

4326
03:46:21,520 --> 03:46:23,080
OPPORTUNITY NOW TO UNDERSTAND 

4327
03:46:23,080 --> 03:46:25,720
RECOVERY AFTER COVID AND SEE IF 

4328
03:46:25,720 --> 03:46:26,800
THAT'S SOMETHING THAT CAN 

4329
03:46:26,800 --> 03:46:28,920
POTENTIALLY BE ALTERED IN THE 

4330
03:46:28,920 --> 03:46:31,080
ACUTE STAGES TO PREVENT PEOPLE 

4331
03:46:31,080 --> 03:46:34,280
FROM DEVELOPING PASC.

4332
03:46:34,280 --> 03:46:34,760
THAT'S A TIME SENSITIVE 

4333
03:46:34,760 --> 03:46:42,920
OPPORTUNITY.

4334
03:46:42,920 --> 03:46:45,680
I WANT TO THANK AMY PATTERSON 

4335
03:46:45,680 --> 03:46:51,920
AND GARY GIBBONS AND YOU CAN'T 

4336
03:46:51,920 --> 03:46:54,000
BELIEVE WHAT A BIG LIFT IT'S 

4337
03:46:54,000 --> 03:46:54,200
BEEN.

4338
03:46:54,200 --> 03:46:55,520
WE THINK IT'S THE RIGHT THING TO

4339
03:46:55,520 --> 03:46:58,440
DO SO FOUR YEARS FROM NOW IF WE 

4340
03:46:58,440 --> 03:47:02,000
DON'T FIGURE IT OUT, IT WON'T BE

4341
03:47:02,000 --> 03:47:03,120
BECAUSE WE DIDN'T TRY EVERYTHING

4342
03:47:03,120 --> 03:47:04,720
WE CAN THINK OF BUT WE HOPE WE 

4343
03:47:04,720 --> 03:47:06,440
CAN FIGURE IT OUT AND MAKE A 

4344
03:47:06,440 --> 03:47:07,600
DIFFERENCE FOR PEOPLE.

4345
03:47:07,600 --> 03:47:08,080
THE SOONER THE BETTER.

4346
03:47:08,080 --> 03:47:09,440
THANKS.

4347
03:47:09,440 --> 03:47:19,760
>> THANKS, WALTER.

4348
03:47:21,200 --> 03:47:23,160
>> THANK YOU, DR.
KOROSHETZ AND 

4349
03:47:23,160 --> 03:47:26,120
RECOVER TEAM FOR YOUR EFFORTS.

4350
03:47:26,120 --> 03:47:32,440
I WAS CURIOUS ABOUT THE GREATER 

4351
03:47:32,440 --> 03:47:35,080
INCIDENTS OF POST-COVID SYMPTOMS

4352
03:47:35,080 --> 03:47:37,680
IN WOMEN AND IN PARALLEL THEY'RE

4353
03:47:37,680 --> 03:47:41,000
REDUCED HOSPITALIZATION FOR 

4354
03:47:41,000 --> 03:47:42,320
THOSE SYSTEMS AND WHETHER 

4355
03:47:42,320 --> 03:47:45,480
THERE'S AN AGE DISTRIBUTION 

4356
03:47:45,480 --> 03:47:51,840
WHERE SPECIFIC AGE GROUP IS MORE

4357
03:47:51,840 --> 03:47:52,440
AFFECT

4358
03:47:52,440 --> 03:47:54,840
AFFECTED WHETHER THERE'S A 

4359
03:47:54,840 --> 03:47:55,560
DISTRIBUTION ACROSS THE CHRONIC 

4360
03:47:55,560 --> 03:47:56,320
SPACE OR SYMPTOMS.

4361
03:47:56,320 --> 03:48:00,560
I KNOW YOU'RE LOOKING AT THIS 

4362
03:48:00,560 --> 03:48:04,040
BUT WHETHER THERE'S TEASERS.

4363
03:48:04,040 --> 03:48:14,480
>> NOT A LOT OF RIGHT NOW.

4364
03:48:18,960 --> 03:48:21,240
AND CLINICS GOT SET UP TO HELP 

4365
03:48:21,240 --> 03:48:23,960
PEOPLE OUT OF ICUs.

4366
03:48:23,960 --> 03:48:25,560
THE BIG SURPRISE WAS THEY FILLED

4367
03:48:25,560 --> 03:48:27,080
UP WITH PEOPLE WHO WERE NEVER 

4368
03:48:27,080 --> 03:48:28,360
EVEN IN THE HOSPITAL.

4369
03:48:28,360 --> 03:48:29,640
THAT WAS A SURPRISE.

4370
03:48:29,640 --> 03:48:32,120
IN THAT GROUP THERE'S A 

4371
03:48:32,120 --> 03:48:36,880
PREDOMINANCE OF WOMEN.

4372
03:48:36,880 --> 03:48:39,640
AND IN THE STUDIES WE DO BY 

4373
03:48:39,640 --> 03:48:41,800
IMMUNE SYSTEM AND NEURAL 

4374
03:48:41,800 --> 03:48:45,320
FUNCTION WOMEN AND MEN ACT 

4375
03:48:45,320 --> 03:48:45,960
DIFFERENTLY.

4376
03:48:45,960 --> 03:48:48,160
THERE'S CERTAIN CONDITIONS, 

4377
03:48:48,160 --> 03:48:50,480
HEADACHE, THAT IS A COMMON 

4378
03:48:50,480 --> 03:48:53,520
PROBLEM IN POST-COVID AND MORE 

4379
03:48:53,520 --> 03:48:58,560
HIGHLY PREVALENT IN WOMEN THAN 

4380
03:48:58,560 --> 03:48:58,960
MEN.

4381
03:48:58,960 --> 03:49:01,680
THE AUTOIMMUNE DISORDER IS MORE 

4382
03:49:01,680 --> 03:49:03,480
PREVALENT IN WOMEN THAN MEN AND 

4383
03:49:03,480 --> 03:49:05,080
THERE MAY BE INCLUDE IN THE SEX 

4384
03:49:05,080 --> 03:49:06,400
GENDER DIFFERENCE WE NEED TO 

4385
03:49:06,400 --> 03:49:07,000
FOLLOW-UP ON.

4386
03:49:07,000 --> 03:49:09,120
IN TERMS OF THE AGE GROUP THAT 

4387
03:49:09,120 --> 03:49:11,360
SEEMS TO BE MOST PREDOMINANT IS 

4388
03:49:11,360 --> 03:49:21,680
MID AGE, 35 TO 55.

4389
03:49:24,880 --> 03:49:25,480
>> THANK YOU.

4390
03:49:25,480 --> 03:49:28,720
>> I'M ASSUMING THIS IS
ALL 

4391
03:49:28,720 --> 03:49:30,280
DOMESTIC, U.S. BASED.

4392
03:49:30,280 --> 03:49:33,040
IS THAT THE CASE, THE CLINICAL 

4393
03:49:33,040 --> 03:49:36,240
COMPONENT.

4394
03:49:36,240 --> 03:49:39,240
I'M WONDERING WHETHER THERE'S 

4395
03:49:39,240 --> 03:49:41,360
OBVIOUSLY COVID IS EVERYWHERE.

4396
03:49:41,360 --> 03:49:47,240
IT SEEMS WE KNOW VERY LITTLE 

4397
03:49:47,240 --> 03:49:51,560
ABOUT THE POST-ACUTE SYNDROME OR

4398
03:49:51,560 --> 03:49:53,640
COVID PARTICULARLY IN LOW AND 

4399
03:49:53,640 --> 03:49:56,080
MIDDLE INCOME COUNTRIES IN 

4400
03:49:56,080 --> 03:50:06,320
PARTICULAR.

4401
03:50:10,560 --> 03:50:13,520
>> THE W.H.O. IS SETTING
UP TO 

4402
03:50:13,520 --> 03:50:15,760
BE ABLE TO ANSWERS TO THE 

4403
03:50:15,760 --> 03:50:18,040
QUESTION YOU ASKED AND THE 

4404
03:50:18,040 --> 03:50:20,000
DEVELOPING SURVEYS TO BE USED IN

4405
03:50:20,000 --> 03:50:24,440
UNDER DEVELOPED COUNTRIES TO 

4406
03:50:24,440 --> 03:50:27,720
ASSESS INCIDENTS OF THE 

4407
03:50:27,720 --> 03:50:33,480
POST-COVID SYNDROME.

4408
03:50:33,480 --> 03:50:43,960
THAT ARE LOOKING AT THE BEST 

4409
03:50:47,000 --> 03:50:48,200
OUTCOME MEASURES TO MEASURE THE 

4410
03:50:48,200 --> 03:50:58,720
BURDEN OF ILLNESS DUE TO COVID.

4411
03:51:04,880 --> 03:51:06,120
>> AND THINKING CLINICAL
TRIALS 

4412
03:51:06,120 --> 03:51:06,360
AS WELL.

4413
03:51:06,360 --> 03:51:16,520
>> YES.

4414
03:51:21,160 --> 03:51:23,000
>> STEP ONE COLLECT THE
DATA, 

4415
03:51:23,000 --> 03:51:26,480
TWO, ANALYZE THE DATA.

4416
03:51:26,480 --> 03:51:28,920
I'M WONDERING WHERE THE THINKING

4417
03:51:28,920 --> 03:51:32,160
IS ON PREPARING THE KNOWLEDGE 

4418
03:51:32,160 --> 03:51:32,800
ENVIRONMENT AND RESEARCH 

4419
03:51:32,800 --> 03:51:34,680
PLATFORM, WHATEVER YOU WANT TO 

4420
03:51:34,680 --> 03:51:36,880
CALL IT TO TAKE THE EXISTING 

4421
03:51:36,880 --> 03:51:39,000
DATA AND ALSO THE INCOMING DET 

4422
03:51:39,000 --> 03:51:41,160
AND THIS IS NOT JUST A 

4423
03:51:41,160 --> 03:51:42,560
TECHNOLOGY QUESTION BUT POLICY 

4424
03:51:42,560 --> 03:51:44,120
AND WHO AND HOW AND ALL THOSE 

4425
03:51:44,120 --> 03:51:51,560
DIFFERENT THINGS.

4426
03:51:51,560 --> 03:51:53,200
>> OUR GOAL IS TO BRING
THE DATA

4427
03:51:53,200 --> 03:52:03,720
TOGETHER TO MAKE IT ACCESSIBLE.

4428
03:52:10,480 --> 03:52:16,480
CORONET IS FEDERATED TO DO 

4429
03:52:16,480 --> 03:52:16,720
QUERIES.

4430
03:52:16,720 --> 03:52:18,840
IN OUR DATA GROUP RIGHT NOW WE 

4431
03:52:18,840 --> 03:52:21,720
HAVE A REGULAR SET OF QUERIES WE

4432
03:52:21,720 --> 03:52:24,440
ARE SENDING TO THEM AND GETTING 

4433
03:52:24,440 --> 03:52:33,880
FEEDBACK ON A REGULAR BASIS AND 

4434
03:52:33,880 --> 03:52:35,640
THE PLAN WOULD BE TO OPEN THAT 

4435
03:52:35,640 --> 03:52:37,240
UP FOR THE WORLD.

4436
03:52:37,240 --> 03:52:38,520
>> WHAT ABOUT THE NEW DATA
TYPES

4437
03:52:38,520 --> 03:52:40,400
YOU'LL BE COLLECTING.

4438
03:52:40,400 --> 03:52:44,160
IT TAKES LEAD TIME FOR THE 

4439
03:52:44,160 --> 03:52:54,760
COHORT DATA AND CORO NET HAD A 

4440
03:52:55,680 --> 03:53:05,160
FEDERATED MODEL.

4441
03:53:05,160 --> 03:53:06,360
>> THERE'S A DATA
COORDINATING 

4442
03:53:06,360 --> 03:53:08,000
CENTER FOR ALL THE DATA COMING 

4443
03:53:08,000 --> 03:53:09,640
IN FROM ALL THE COHORTS AT THIS 

4444
03:53:09,640 --> 03:53:18,280
POINT.

4445
03:53:18,280 --> 03:53:23,840
LINK TO THE BIO SAPECIMENS AND 

4446
03:53:23,840 --> 03:53:25,440
IMAGING AND HOPEFULLY ELECTRONIC

4447
03:53:25,440 --> 03:53:25,800
HEALTH RECORDS.

4448
03:53:25,800 --> 03:53:28,040
I THINK THAT WOULD BE GOOD WAY 

4449
03:53:28,040 --> 03:53:31,680
OF GOLD STANDARD WAY OF 

4450
03:53:31,680 --> 03:53:36,200
DEVELOPING NEW SIGNATURES FOR 

4451
03:53:36,200 --> 03:53:37,920
THE ELECTRONIC HEALTH RECORD 

4452
03:53:37,920 --> 03:53:38,480
SEARCHS.

4453
03:53:38,480 --> 03:53:39,920
PORTAL IS BEING BUILT BY THE 

4454
03:53:39,920 --> 03:53:41,160
DATA CENTER.

4455
03:53:41,160 --> 03:53:44,840
WE WANT THAT OPEN IN THE SENSE 

4456
03:53:44,840 --> 03:53:47,480
THAT REPUTABLE INVESTIGATORS 

4457
03:53:47,480 --> 03:53:49,480
WILL GET TO THE DATA.

4458
03:53:49,480 --> 03:53:53,000
AND MAYO CLINICAL AND THOSE ALSO

4459
03:53:53,000 --> 03:53:54,760
SUING YOU HAVE THESE PEOPLE WHO 

4460
03:53:54,760 --> 03:53:56,720
WRITE A PAPER SAYING THEY FOUND 

4461
03:53:56,720 --> 03:53:57,560
X, Y AND Z.

4462
03:53:57,560 --> 03:53:59,560
WE SHOULD BE ABLE TO GO TO THE 

4463
03:53:59,560 --> 03:54:01,960
SAMPLE COLLECTIONS AND VALIDATE 

4464
03:54:01,960 --> 03:54:04,160
IT IN OUR GROUP AS WELL.

4465
03:54:04,160 --> 03:54:07,680
THE GOAL IS TO OPEN THIS UP.

4466
03:54:07,680 --> 03:54:10,520
>> GREAT, THANK YOU,
WALTER.

4467
03:54:10,520 --> 03:54:13,040
I KNOW THERE'S MORE 

4468
03:54:13,040 --> 03:54:16,400
CONVERSATIONS WITH THE "ALL OF 

4469
03:54:16,400 --> 03:54:18,040
US" DATA DATA TEAM MAY BE ABLE 

4470
03:54:18,040 --> 03:54:19,880
TO ASSIST OR CORRELATE OR STAND 

4471
03:54:19,880 --> 03:54:21,960
ON EACH OTHER'S SHOULDERS, HAPPY

4472
03:54:21,960 --> 03:54:23,800
TO MOVE THAT FORWARD.

4473
03:54:23,800 --> 03:54:34,360
>> BE CAREFUL WHAT YOU ASK
FOR.

4474
03:54:43,640 --> 03:54:46,000
>> THERE'S ACADEMIC
CENTERS.

4475
03:54:46,000 --> 03:54:48,440
WHAT ABOUT COMMUNITY CENTERS, 

4476
03:54:48,440 --> 03:54:53,480
V.A., FEDERALLY QUALIFIED HEALTH

4477
03:54:53,480 --> 03:54:53,880
CENTERS.

4478
03:54:53,880 --> 03:54:55,840
TAKING INTO ACCOUNT TO WHAT 

4479
03:54:55,840 --> 03:54:58,160
LARRY TABAK SAID EARLIER NOT THE

4480
03:54:58,160 --> 03:54:59,600
USUAL CENTERS GETTING THE 

4481
03:54:59,600 --> 03:55:02,520
FUNDING LIKE WITH COVID AND 

4482
03:55:02,520 --> 03:55:04,280
REACH THE COMMUNITY BEYOND THE 

4483
03:55:04,280 --> 03:55:06,440
MEDICAL CENTERS.

4484
03:55:06,440 --> 03:55:07,640
>> BEYOND THE ELECTRONIC
HEALTH 

4485
03:55:07,640 --> 03:55:08,560
RECORD, I THINK I HAVE TO TAKE 

4486
03:55:08,560 --> 03:55:10,840
THAT BACK AND SEE WHAT THE 

4487
03:55:10,840 --> 03:55:12,200
POSSIBILITIES ARE THERE.

4488
03:55:12,200 --> 03:55:15,880
THAT'S A GREAT IDEA.

4489
03:55:15,880 --> 03:55:19,160
THE V.A. HAS BEEN VERY 

4490
03:55:19,160 --> 03:55:22,000
AGGRESSIVE AND PUBLISHED HEAVILY

4491
03:55:22,000 --> 03:55:23,760
ALREADY ON THE ELECTRONIC HEALTH

4492
03:55:23,760 --> 03:55:26,240
RECORD DATA IN VETERANS WHO 

4493
03:55:26,240 --> 03:55:27,680
DEVELOPED COVID.

4494
03:55:27,680 --> 03:55:29,480
SOME OF THE BEST DATA'S COME 

4495
03:55:29,480 --> 03:55:39,720
FROM THE V.A.

4496
03:55:47,160 --> 03:55:48,960
>> CAN YOU TAKE STEPS TO 

4497
03:55:48,960 --> 03:55:52,200
INCREASE PATIENT ENGAGEMENT 

4498
03:55:52,200 --> 03:55:55,640
SINCE THE LAST ACD MEETING.

4499
03:55:55,640 --> 03:55:58,200
>> WE HAVE DEVELOPED A
STEER 

4500
03:55:58,200 --> 03:55:59,320
COMMITTEE AND PATIENT COMMITTEES

4501
03:55:59,320 --> 03:56:02,360
WITH ENGAGEMENT ON THEM AT THE 

4502
03:56:02,360 --> 03:56:05,720
DIFFERENT SITES.

4503
03:56:05,720 --> 03:56:07,440
WE HAVE PATIENTS THAT PATIENTS 

4504
03:56:07,440 --> 03:56:08,720
THAT HAVE BEEN INTEGRATE INTO 

4505
03:56:08,720 --> 03:56:13,080
THE STUDIES AT THE SITES AND 

4506
03:56:13,080 --> 03:56:19,960
HUBS AND CONTINUE TO HAVE 

4507
03:56:19,960 --> 03:56:25,480
SESSIONS WHERE WE GET INPUT FROM

4508
03:56:25,480 --> 03:56:35,600
FOLKS.

4509
03:56:48,200 --> 03:56:51,280
>> WE HAVE THE EXECUTIVE 

4510
03:56:51,280 --> 03:56:52,600
COMMITTEE AND STEERING COMMITTEE

4511
03:56:52,600 --> 03:56:54,520
AND 12 PATHOBIOLOGY TASK FORCES 

4512
03:56:54,520 --> 03:56:57,400
AND SIX OVERSIGHT COMMITTEES.

4513
03:56:57,400 --> 03:57:02,440
>> PART OF THE CHALLENGE
HAS 

4514
03:57:02,440 --> 03:57:05,720
BEEN FOR PEOPLE SUFFERING FROM 

4515
03:57:05,720 --> 03:57:07,760
LONG COVID WANT TO KNOW WHAT CAN

4516
03:57:07,760 --> 03:57:12,000
YOU DO FOR ME NOW.

4517
03:57:12,000 --> 03:57:15,800
THERE'S AN IMMEDIATE PRACTICAL 

4518
03:57:15,800 --> 03:57:18,240
REQUEST WHAT CAN YOU DO FOR ME 

4519
03:57:18,240 --> 03:57:18,480
NOW?

4520
03:57:18,480 --> 03:57:20,800
DON'T TELL ME ABOUT YOUR STUDIES

4521
03:57:20,800 --> 03:57:22,080
OR HOW HARD IT IS, TELL ME WHAT 

4522
03:57:22,080 --> 03:57:32,440
YOU CAN DO FOR ME NOW.

4523
03:57:46,760 --> 03:57:48,280
THERE'S NOTHING SURPRISING HERE.

4524
03:57:48,280 --> 03:57:50,000
IF YOU LOOK AT THE APPROACHES 

4525
03:57:50,000 --> 03:57:51,680
THAT WORKED FOR THE ACUTE 

4526
03:57:51,680 --> 03:57:55,680
DISEASE COULD SOME POTENTIALLY 

4527
03:57:55,680 --> 03:58:04,840
WORK FOR THE LONG COVID.

4528
03:58:04,840 --> 03:58:06,840
THE OTHER IS BALANCING WHO YOU 

4529
03:58:06,840 --> 03:58:07,080
ENROLL.

4530
03:58:07,080 --> 03:58:09,320
IF YOU'RE NOT CAREFUL AND I KNOW

4531
03:58:09,320 --> 03:58:11,880
THE TEAM IS ATTUNE TO THIS, 

4532
03:58:11,880 --> 03:58:17,480
YOU'LL WIND UP WITH 

4533
03:58:17,480 --> 03:58:20,920
OVERWHELMINGLY WHITE FEMALE 

4534
03:58:20,920 --> 03:58:31,120
POPULATION.

4535
03:58:31,440 --> 03:58:32,960
YOU ALSO WANT TO UNDERSTAND HOW 

4536
03:58:32,960 --> 03:58:34,400
THIS IS ADVERSELY AFFECTING 

4537
03:58:34,400 --> 03:58:44,920
OTHER MEMBERS OF THE COMMUNITY.

4538
03:58:46,920 --> 03:58:48,440
SOME PEOPLE MAKE THE INQUIRY, 

4539
03:58:48,440 --> 03:58:50,120
I'M NOT BEING ENROLLED AND PART 

4540
03:58:50,120 --> 03:58:52,000
IS BECAUSE THE NEED TO BALANCE 

4541
03:58:52,000 --> 03:59:01,360
THINGS UP.

4542
03:59:01,360 --> 03:59:03,240
THERE'S SUGGESTIONS IN THE CHAT 

4543
03:59:03,240 --> 03:59:05,760
BOX ENGAGING WITH PHARMACIES AND

4544
03:59:05,760 --> 03:59:07,680
THE WALGREENS OF THE WORLD AND 

4545
03:59:07,680 --> 03:59:09,600
ALL OF THIS HAVE DONE THIS 

4546
03:59:09,600 --> 03:59:11,080
PRETTY EFFECTIVELY.

4547
03:59:11,080 --> 03:59:13,640
THERE MAY BE LESSONS LEARNED 

4548
03:59:13,640 --> 03:59:23,880
THERE AS WELL.

4549
03:59:29,080 --> 03:59:31,760
>> THOUSANDS OF PEOPLE ARE

4550
03:59:31,760 --> 03:59:33,160
AFFECTED AND THEY'RE TRYING 

4551
03:59:33,160 --> 03:59:34,480
DIFFERENT WAYS OF TREATING 

4552
03:59:34,480 --> 03:59:38,880
PEOPLE TO TEST SOME THINGS MAYBE

4553
03:59:38,880 --> 03:59:40,080
BRING BEST PRACTICES OUT SEEMS 

4554
03:59:40,080 --> 03:59:44,040
LIKE A LOGICAL STEP WE CAN DO 

4555
03:59:44,040 --> 03:59:45,480
NOW AND SO I THINK THAT WOULD BE

4556
03:59:45,480 --> 03:59:55,760
THE FIRST START.

4557
04:00:04,760 --> 04:00:06,400
THE LATER IT WILL BE HARDER TO 

4558
04:00:06,400 --> 04:00:08,120
GET PEOPLE TO THAT HIGHER 

4559
04:00:08,120 --> 04:00:18,440
FUNCTIONAL LEVEL.

4560
04:00:22,960 --> 04:00:27,640
>> ANY LAST QUESTION FOR
WALTER?

4561
04:00:27,640 --> 04:00:30,600
>> RECOVERCOVID.org.

4562
04:00:30,600 --> 04:00:31,600
TELL EVERYBODY TO SIGN UP IF YOU

4563
04:00:31,600 --> 04:00:33,480
GET INFECTED.

4564
04:00:33,480 --> 04:00:43,800
HOPEFULLY YOU DON'T.

4565
04:00:45,560 --> 04:00:51,920
>> WE HAVE DIANA ON AND
WE'RE 

4566
04:00:51,920 --> 04:00:54,360
EARLY SO HOPEFULLY WE CAN START 

4567
04:00:54,360 --> 04:01:01,360
THE BREAK EARLIER.

4568
04:01:01,360 --> 04:01:04,160
>> I'M COMING TO EVERYONE
THE 

4569
04:01:04,160 --> 04:01:07,920
WESTIN IN LONG BEACH, CALIFORNIA

4570
04:01:07,920 --> 04:01:09,040
THE RESEARCH SOCIETY MEETINGS 

4571
04:01:09,040 --> 04:01:12,360
ARE GOING ON HERE AND NIH HAS A 

4572
04:01:12,360 --> 04:01:15,200
BIG PRESENCE DUE TO THE $70 

4573
04:01:15,200 --> 04:01:16,600
MILLION INVESTMENT.

4574
04:01:16,600 --> 04:01:20,120
IT'S VERY EXCITING.

4575
04:01:20,120 --> 04:01:20,920
I APOLOGIZE.

4576
04:01:20,920 --> 04:01:22,600
I HAVEN'T HEARD WALTER'S 

4577
04:01:22,600 --> 04:01:24,800
PRESENTATION BUT HOPEFULLY 

4578
04:01:24,800 --> 04:01:29,560
TECHNICALLY EVERYTHING IS 

4579
04:01:29,560 --> 04:01:37,400
WORKING WELL.

4580
04:01:37,400 --> 04:01:39,520
I'LL TALK ABOUT THINGS THAT 

4581
04:01:39,520 --> 04:01:41,120
DON'T GET A LOT OF ATTENTION IN 

4582
04:01:41,120 --> 04:01:43,240
TERMS OF THE AFFECTS OF COVID-19

4583
04:01:43,240 --> 04:01:45,560
ON DIFFERENT BODY SYSTEMS.

4584
04:01:45,560 --> 04:01:48,480
WE DON'T WANT TO FORGET THEM 

4585
04:01:48,480 --> 04:01:49,160
BECAUSE THEY'RE IMPORTANT.

4586
04:01:49,160 --> 04:01:52,640
I'LL BE TALKING ABOUT COVID-19 

4587
04:01:52,640 --> 04:01:57,680
EFFECTS ON FEMALE AND MALE 

4588
04:01:57,680 --> 04:02:02,760
REPRODUCTIVE SYMPTOMS AND TALK 

4589
04:02:02,760 --> 04:02:06,600
ABOUT COVID-19 VACCINATION AND 

4590
04:02:06,600 --> 04:02:11,800
PREGNANCY AND LACTATION AND 

4591
04:02:11,800 --> 04:02:13,160
WE'VE MADE SIGNIFICANT PROGRESS 

4592
04:02:13,160 --> 04:02:17,120
AND I WANTED YOU TO KNOW AND 

4593
04:02:17,120 --> 04:02:17,680
WILL END ON THREE FUTURE 

4594
04:02:17,680 --> 04:02:27,880
CHALLENGES.

4595
04:02:34,880 --> 04:02:39,240
THERE'S BEEN A LOT OF ANECDOTAL 

4596
04:02:39,240 --> 04:02:41,720
REPORTS ON CHANGES TO MENSTRUAL 

4597
04:02:41,720 --> 04:02:44,560
CYCLES AMPLIFIED ON SOCIAL MEDIA

4598
04:02:44,560 --> 04:02:47,320
AND BACK IN APRIL THE TITLE OF 

4599
04:02:47,320 --> 04:02:48,960
AN ARTICLE WAS NO, WE DON'T FLOW

4600
04:02:48,960 --> 04:02:50,400
IF VACCINES CHANGE YOUR PERIOD.

4601
04:02:50,400 --> 04:02:55,160
I CAN SAY THE ANSWER IS YES NOW 

4602
04:02:55,160 --> 04:02:57,360
DUE TO NIH FUNDED RESEARCH.

4603
04:02:57,360 --> 04:03:00,920
WOMEN WERE CONSISTENTLY 

4604
04:03:00,920 --> 04:03:02,200
REPORTING CHANGES TO THE TIMES 

4605
04:03:02,200 --> 04:03:04,520
OF MENSTRUAL CYCLES.

4606
04:03:04,520 --> 04:03:07,960
THE FACT THEY SKIPPED PERIODS.

4607
04:03:07,960 --> 04:03:11,040
WOMEN WHO HAD UNDER GONE 

4608
04:03:11,040 --> 04:03:12,440
MENOPAUSE NOW BLEEDING AND 

4609
04:03:12,440 --> 04:03:14,120
BETWEEN CYCLES AND CHANGES IN 

4610
04:03:14,120 --> 04:03:16,120
MENSTRUAL FLOW AND COMORBIDITIES

4611
04:03:16,120 --> 04:03:17,480
SUCH AS INCREASED PAIN DURING 

4612
04:03:17,480 --> 04:03:18,560
MENSTRUAL CYCLES.

4613
04:03:18,560 --> 04:03:20,600
WE DIDN'T KNOW ABOUT VACCINES 

4614
04:03:20,600 --> 04:03:23,320
AND HOW THEY AFFECTED PERIODS 

4615
04:03:23,320 --> 04:03:25,400
BECAUSE DATA ON MENSTRUAL 

4616
04:03:25,400 --> 04:03:27,560
CHANGES ARE NOT ROUTINELY 

4617
04:03:27,560 --> 04:03:29,480
COLLECTED DURING VACCINE SAFETY 

4618
04:03:29,480 --> 04:03:29,720
TRIALS.

4619
04:03:29,720 --> 04:03:33,280
IT'S NOT UNIQUE TO THE SARS COV2

4620
04:03:33,280 --> 04:03:34,680
VACCINES IT'S NOT GENERALLY 

4621
04:03:34,680 --> 04:03:36,200
COLLECTED AND WE WOULD ARGUE IT 

4622
04:03:36,200 --> 04:03:37,240
NEEDS TO BE COLLECTED.

4623
04:03:37,240 --> 04:03:38,520
WE RECOGNIZE THERE WAS A GAP IN 

4624
04:03:38,520 --> 04:03:39,040
THE DATA.

4625
04:03:39,040 --> 04:03:40,840
THIS IS SOMETHING WE CHECKED IN 

4626
04:03:40,840 --> 04:03:43,560
WITH NIAID AND WERE NOT LOOKING 

4627
04:03:43,560 --> 04:03:49,360
AT AND ALIGNED WITH OUR 

4628
04:03:49,360 --> 04:03:50,640
INTERESTS BECAUSE WE ARE 

4629
04:03:50,640 --> 04:03:52,440
CURRENTLY FUNDING INVESTIGATORS 

4630
04:03:52,440 --> 04:03:56,760
STUDYING THE MENSTRUAL CYCLES 

4631
04:03:56,760 --> 04:04:03,280
FOR A VARIETY OF REASONS.

4632
04:04:03,280 --> 04:04:04,960
THE STAFF AT THE HEALTH AND 

4633
04:04:04,960 --> 04:04:07,720
DISEASE BRANCH AWARDED $1.6 

4634
04:04:07,720 --> 04:04:08,280
MILLION TO FIVE DIFFERENT 

4635
04:04:08,280 --> 04:04:18,720
INSTITUTIONS LAST SUMMER.

4636
04:04:27,760 --> 04:04:29,320
THERE WERE OVER 15,000 WOMEN 

4637
04:04:29,320 --> 04:04:31,280
THEY WERE TRACKING WHO WERE 

4638
04:04:31,280 --> 04:04:32,160
QUITE DIVERSE BOTH 

4639
04:04:32,160 --> 04:04:33,880
GEOGRAPHICALLY AND RACIALLY AND 

4640
04:04:33,880 --> 04:04:35,960
ETHNICALLY AND THEY WERE LOOKING

4641
04:04:35,960 --> 04:04:39,480
AT HOW CONFOUNDERS LIKE STRESS 

4642
04:04:39,480 --> 04:04:41,720
AND INFORMATION BIAS AFFECT THE 

4643
04:04:41,720 --> 04:04:42,760
MENSTRUAL CYCLE.

4644
04:04:42,760 --> 04:04:44,480
WE'VE ALL BEEN THROUGH STRESSFUL

4645
04:04:44,480 --> 04:04:46,800
TIMES SO IT COULD BE IT'S STRESS

4646
04:04:46,800 --> 04:04:48,280
AFFECTING THE MENSTRUAL CYCLE 

4647
04:04:48,280 --> 04:04:58,760
AND NOT THE VACCINES AT ALL.

4648
04:04:59,400 --> 04:05:01,080
THEY WERE BEING STARTED BY 

4649
04:05:01,080 --> 04:05:04,320
DR. PAIN AT HARVARD COLLECTING 

4650
04:05:04,320 --> 04:05:05,480
SALIVA FOR VARIOUS HORMONE 

4651
04:05:05,480 --> 04:05:05,800
STUDIES.

4652
04:05:05,800 --> 04:05:08,560
WE ALSO HAVE A NUMBER OF 

4653
04:05:08,560 --> 04:05:12,360
REQUESTS WHO ARE USING MENSTRUAL

4654
04:05:12,360 --> 04:05:14,400
TRACKING AND LOOKING AT VARIOUS 

4655
04:05:14,400 --> 04:05:20,160
WAYS TO QUANTIFY MENSTRUAL FLOW.

4656
04:05:20,160 --> 04:05:24,480
THIS MICHIGAN STATE STATE 

4657
04:05:24,480 --> 04:05:28,200
TRACKING WOMEN FOR MANY YEARS 

4658
04:05:28,200 --> 04:05:32,120
WITH A PARTICULAR EMPHASIS ON 

4659
04:05:32,120 --> 04:05:37,240
ENDOMETRIOSIS ASSOCIATED WITH 

4660
04:05:37,240 --> 04:05:43,920
EXTREME PAIN.

4661
04:05:43,920 --> 04:05:44,800
AND OREGON UNIVERSITY WAS ABLE 

4662
04:05:44,800 --> 04:05:46,120
TO COME UP WITH RESULTS QUICKLY 

4663
04:05:46,120 --> 04:05:48,840
AND THEY'RE USING A NUMBER OF 

4664
04:05:48,840 --> 04:05:54,560
DIFFERENT FERTILITY AWARENESS 

4665
04:05:54,560 --> 04:06:03,840
APPS ON THE SMARTPHONE TO TRACK 

4666
04:06:03,840 --> 04:06:14,160
MENSTRUAL CYCLES.

4667
04:06:38,240 --> 04:06:40,000
FINDINGS SHOW IF YOU GOT ONE 

4668
04:06:40,000 --> 04:06:49,480
DOSE OF MODERNA OR PFIZER IT 

4669
04:06:49,480 --> 04:06:55,360
LENGTHENED THE INTERVAL OF 

4670
04:06:55,360 --> 04:06:57,600
MENSTRUATION BY ONE DAY AND IF 

4671
04:06:57,600 --> 04:07:01,000
YOU GOT THE PFIZER VACCINE IN 

4672
04:07:01,000 --> 04:07:03,360
THE SAME CYCLE LENGENED BY TWO 

4673
04:07:03,360 --> 04:07:04,280
DAYS.

4674
04:07:04,280 --> 04:07:06,880
THE INTERVAL WAS LENGTHENED BUT 

4675
04:07:06,880 --> 04:07:12,600
NOT THE NUMBER OF MENSES WERE 

4676
04:07:12,600 --> 04:07:15,560
BLEEDING AND ONLY LASTED FOR THE

4677
04:07:15,560 --> 04:07:16,600
CYCLE FOLLOWING THE VACCINATION.

4678
04:07:16,600 --> 04:07:19,200
THE NEXT CYCLE RETURNED TO 

4679
04:07:19,200 --> 04:07:25,480
NORMAL AND SUBSEQUENT CYCLES.

4680
04:07:25,480 --> 04:07:28,200
IMPORTANTLY THIS MINIMAL 

4681
04:07:28,200 --> 04:07:33,640
INCREASE IN LENGTH IS NOT 

4682
04:07:33,640 --> 04:07:34,920
CONSIDERED SIGNIFICANT AND 

4683
04:07:34,920 --> 04:07:38,920
THERE'S A CYCLE LENGTH AS NORMAL

4684
04:07:38,920 --> 04:07:49,400
IF IT'S LESS THAN TWO DAYS.

4685
04:07:52,920 --> 04:08:03,360
WE SHOULD FIND OUT THE STUDY 

4686
04:08:05,560 --> 04:08:09,320
RECEIVED ENORMOUS ATTENTION AND 

4687
04:08:09,320 --> 04:08:11,640
ON SOCIAL MEDIA AND THE LAY 

4688
04:08:11,640 --> 04:08:16,640
MEDIA AND WE WERE DULU DELUGED  

4689
04:08:16,640 --> 04:08:19,520
WOMEN WOULD WANTED TO SHARE 

4690
04:08:19,520 --> 04:08:21,200
THEIR EXPERIENCE AND WE WERE 

4691
04:08:21,200 --> 04:08:25,760
TOLD THE DATA PROVIDED 

4692
04:08:25,760 --> 04:08:27,120
REASSURANCE THAT VACCINATION 

4693
04:08:27,120 --> 04:08:29,760
DOES NOT AFFECT THE MENSTRUAL 

4694
04:08:29,760 --> 04:08:29,960
CYCLE.

4695
04:08:29,960 --> 04:08:32,920
THIS IS FOLLOWED BY ANOTHER 

4696
04:08:32,920 --> 04:08:34,920
PRELIMINARY STUDY SHOWING NO 

4697
04:08:34,920 --> 04:08:36,720
EFFECTS ON FERTILITY WHICH IS 

4698
04:08:36,720 --> 04:08:38,520
ANOTHER AREA WHERE THERE'S BEEN 

4699
04:08:38,520 --> 04:08:41,480
A TREMENDOUS AMOUNT OF 

4700
04:08:41,480 --> 04:08:51,760
MISINFORMATION.

4701
04:08:53,520 --> 04:08:56,320
THERE'S A PORTFOLIO FOR THE MALE

4702
04:08:56,320 --> 04:08:57,800
REPRODUCTIVE SYSTEM AND WE'VE 

4703
04:08:57,800 --> 04:09:01,480
BEEN INTERESTED HOW COVID-19 

4704
04:09:01,480 --> 04:09:02,760
INFECTION AND COVID-19 

4705
04:09:02,760 --> 04:09:05,480
VACCINATION AFFECT MALE 

4706
04:09:05,480 --> 04:09:07,720
FERTILITY AS WELL.

4707
04:09:07,720 --> 04:09:09,520
THERE'S NO EVIDENCE THAT 

4708
04:09:09,520 --> 04:09:10,640
VACCINATION AFFECTS FERTILITY 

4709
04:09:10,640 --> 04:09:13,480
FROM THE MALE BUT WE HAVE SOME 

4710
04:09:13,480 --> 04:09:16,480
DATA THAT SUGGEST COVID-19 

4711
04:09:16,480 --> 04:09:19,720
INFECTION CAN TEMPORARILY REDUCE

4712
04:09:19,720 --> 04:09:20,200
MALE FERTILITY.

4713
04:09:20,200 --> 04:09:22,400
BY ONE STUDY OF INVESTIGATORS IT

4714
04:09:22,400 --> 04:09:24,400
WAS SHOWN THERE WAS AN 18% LOWER

4715
04:09:24,400 --> 04:09:26,480
CHANCE OF CONCEPTION IF THE MALE

4716
04:09:26,480 --> 04:09:29,920
PARTNER WAS INFECTED WITHIN 60 

4717
04:09:29,920 --> 04:09:32,720
DAYS BEFORE THE MENSTRUAL CYCLE 

4718
04:09:32,720 --> 04:09:35,160
THAT RESULTED IN CONCEPTION OF A

4719
04:09:35,160 --> 04:09:43,840
CHILD.

4720
04:09:43,840 --> 04:09:44,760
OVER ALL IF YOU LOOKED OVER THE 

4721
04:09:44,760 --> 04:09:46,840
COURSE OF THE YEAR IF YOU WERE 

4722
04:09:46,840 --> 04:09:49,200
INFECTED WITH SARS COV2 THERE 

4723
04:09:49,200 --> 04:09:50,960
WASN'T A LONG EFFECT THIS 

4724
04:09:50,960 --> 04:09:55,160
SUGGESTS A TEMPORARY EFFECT OF 

4725
04:09:55,160 --> 04:09:57,000
EITHER VACCINATION OR 

4726
04:09:57,000 --> 04:09:59,160
VACCINATION IN THE FEMALE OR 

4727
04:09:59,160 --> 04:10:03,880
INFECTION ON THE MALE UPON 

4728
04:10:03,880 --> 04:10:04,760
FERTILITY.

4729
04:10:04,760 --> 04:10:05,560
THE NEW YORK TIMES INTERESTING 

4730
04:10:05,560 --> 04:10:08,920
AND THOUGHT-PROVOKING ARTICLE 

4731
04:10:08,920 --> 04:10:11,000
CAN COVID LEAD TO IMPOTENCE.

4732
04:10:11,000 --> 04:10:13,160
WE DON'T KNOW THE ANSWER AND I 

4733
04:10:13,160 --> 04:10:16,240
SEE WALTER STILL ON SO I CAN 

4734
04:10:16,240 --> 04:10:18,000
PERHAPS ASK HIM TO WEIGH IN 

4735
04:10:18,000 --> 04:10:23,360
AFTER I'M DONE WHETHER WE'RE 

4736
04:10:23,360 --> 04:10:25,480
COLLECTING INFORMATION ON ANY 

4737
04:10:25,480 --> 04:10:28,120
SEXUAL DYSFUNCTION OR PROBLEMS 

4738
04:10:28,120 --> 04:10:32,720
WITH ERECTILE DYSFUNCTION IN MEN

4739
04:10:32,720 --> 04:10:37,360
BECAUSE IT'S BEEN SUGGESTED 

4740
04:10:37,360 --> 04:10:45,960
CORONAVIRUS CAN INFECT THE MALE 

4741
04:10:45,960 --> 04:10:51,440
GEN  GENITAL TRACT AND THEY'RE 

4742
04:10:51,440 --> 04:11:01,960
SEEING AFFECT IN YOUNGER MEN.

4743
04:11:05,440 --> 04:11:07,360
GOING BACK TO VACCINATION IN THE

4744
04:11:07,360 --> 04:11:10,840
FEMALE POPULATION, WE'VE BEEN 

4745
04:11:10,840 --> 04:11:12,760
INTERESTED IN ASSURE VACCINATION

4746
04:11:12,760 --> 04:11:15,760
IS SAFE PARTICULARLY WHILE 

4747
04:11:15,760 --> 04:11:16,840
PREGNANT OR BREAST FEEDING WE 

4748
04:11:16,840 --> 04:11:20,440
FUNDED A NUMBER OF STUDIES THAT 

4749
04:11:20,440 --> 04:11:22,920
HAVE LOOKED AT HOW VACCINATION 

4750
04:11:22,920 --> 04:11:23,960
AFFECTS ANTIBODY LEVELS.

4751
04:11:23,960 --> 04:11:25,600
FOR EXAMPLE IN THE FIRST BULLET 

4752
04:11:25,600 --> 04:11:30,000
THE ANTIBODY LEVELS ARE HIGHER 

4753
04:11:30,000 --> 04:11:32,840
IN WOMEN POST VACCINATION 

4754
04:11:32,840 --> 04:11:34,080
PREGNANT VERSUS NATURAL 

4755
04:11:34,080 --> 04:11:37,840
INFECTION DURING PREGNANCY.

4756
04:11:37,840 --> 04:11:40,920
FURTHERMORE THE VACCINE-INDUCED 

4757
04:11:40,920 --> 04:11:42,320
ANTIBODIES ARE PRESENT IN BREAST

4758
04:11:42,320 --> 04:11:43,320
MILK SAMPLES.

4759
04:11:43,320 --> 04:11:46,840
I ALWAYS LIKE TO TELL PEOPLE YOU

4760
04:11:46,840 --> 04:11:49,480
ARE CONCERNED ABOUT YOUR BABY 

4761
04:11:49,480 --> 04:11:56,960
WHO IS UNDER OF 6 MONTHS EVEN IF

4762
04:11:56,960 --> 04:11:59,240
THE VACCINES ARE APPROVED THE 

4763
04:11:59,240 --> 04:12:01,800
BEST PROTECTION FOR THE BABY IS 

4764
04:12:01,800 --> 04:12:03,840
TO GET VACCINATED WHILE PREGNANT

4765
04:12:03,840 --> 04:12:06,280
AND BREAST FEED THE BABY BECAUSE

4766
04:12:06,280 --> 04:12:09,080
THE VACCINE INDUCED ANTIBODIES 

4767
04:12:09,080 --> 04:12:10,720
ARE TRANSFERRED TO BREAST MILK 

4768
04:12:10,720 --> 04:12:12,520
AND THERE'S CONCERN ABOUT THE 

4769
04:12:12,520 --> 04:12:13,920
TIMING WHEN IS BEST.

4770
04:12:13,920 --> 04:12:15,200
IF YOU'VE NEVER BEEN VACCINATED 

4771
04:12:15,200 --> 04:12:17,120
IT'S PROBABLY BEST TO GET 

4772
04:12:17,120 --> 04:12:17,720
VACCINATED IN THE FIRST 

4773
04:12:17,720 --> 04:12:21,960
TRIMESTER OF PREGNANCY.

4774
04:12:21,960 --> 04:12:25,200
THERE ARE POTENTIAL MATERNAL AND

4775
04:12:25,200 --> 04:12:28,120
FETAL BENEFITS WITH REDUCTION OF

4776
04:12:28,120 --> 04:12:31,800
INFLAMMATION IN THE PLACENTA AND

4777
04:12:31,800 --> 04:12:34,040
WOMB AND WHAT THE FETUS IS 

4778
04:12:34,040 --> 04:12:34,680
EXPOSED TO.

4779
04:12:34,680 --> 04:12:37,320
HOWEVER, IF YOU HAVE BEEN 

4780
04:12:37,320 --> 04:12:38,400
VACCINATED IT WILL BE HELPFUL TO

4781
04:12:38,400 --> 04:12:41,640
HAVE A BOOSTER IN THE THIRD 

4782
04:12:41,640 --> 04:12:41,880
TRIMESTER.

4783
04:12:41,880 --> 04:12:44,120
THERE'S BEEN NO EVIDENCE 

4784
04:12:44,120 --> 04:12:46,400
VACCINES CAUSE ANY COMPLICATIONS

4785
04:12:46,400 --> 04:12:51,200
IN PREGNANT PEOPLE BUT THAT'S 

4786
04:12:51,200 --> 04:12:52,680
THERE'S BEEN CONCERN 300 

4787
04:12:52,680 --> 04:12:58,800
PREGNANT WOMEN HAVE DIED AND 

4788
04:12:58,800 --> 04:13:01,480
PROBABLY NEEDLESSLY BECAUSE THEY

4789
04:13:01,480 --> 04:13:11,800
WERE UNVACCINATED.

4790
04:13:21,920 --> 04:13:23,480
THERE'S PROTECTION AGAINST 

4791
04:13:23,480 --> 04:13:25,240
HOSPITALIZATION IF THE MOTHER 

4792
04:13:25,240 --> 04:13:27,200
HAD BEEN VACCINATED.

4793
04:13:27,200 --> 04:13:29,520
THE INFANTS WERE HOSPITALIZED 

4794
04:13:29,520 --> 04:13:32,200
LARGELY BECAUSE THE MOTHERS WERE

4795
04:13:32,200 --> 04:13:42,760
NOT VACCINATED DURING PREGNANCY.

4796
04:13:50,440 --> 04:13:51,240
MISC IS MULTI-SYSTEM 

4797
04:13:51,240 --> 04:13:51,920
INFLAMMATORY SYNDROME IN 

4798
04:13:51,920 --> 04:13:54,840
CHILDREN WITH LABORATORY 

4799
04:13:54,840 --> 04:13:56,120
DIAGNOSTICS AND ARTIFICIAL 

4800
04:13:56,120 --> 04:13:56,480
INTELLIGENCE.

4801
04:13:56,480 --> 04:13:59,480
AND THIS PROGRAM WAS FUNDED 

4802
04:13:59,480 --> 04:14:03,960
THROUGH THE RADX RADICAL 

4803
04:14:03,960 --> 04:14:09,600
INITIATIVE LOOKING TO PREDICT 

4804
04:14:09,600 --> 04:14:10,800
WHICH CHILDREN WILL DEVELOP MISC

4805
04:14:10,800 --> 04:14:13,520
NOW INCLUDED IN THE UMBRELLA OF 

4806
04:14:13,520 --> 04:14:14,160
CONDITIONS THAT ARE KNOWN AS 

4807
04:14:14,160 --> 04:14:16,800
LONG COVID.

4808
04:14:16,800 --> 04:14:20,120
MISC IS ONE OF THE PEDIATRIC 

4809
04:14:20,120 --> 04:14:30,480
FORMS OF LONG COVID.

4810
04:15:33,520 --> 04:15:35,680
[TECHNICAL DIFFICULTIES]

4811
04:15:35,680 --> 04:15:39,840
AND THERE'S THE NIH THE SMALL 

4812
04:15:39,840 --> 04:15:41,040
BUSINESS EDUCATION AND 

4813
04:15:41,040 --> 04:15:42,320
ENTREPRENEURIAL PROGRAM FUNDED 

4814
04:15:42,320 --> 04:15:45,000
BY THE NIH OFFICE OF THE 

4815
04:15:45,000 --> 04:15:45,720
DIRECTOR AND EXTRAMURAL 

4816
04:15:45,720 --> 04:15:46,000
RESEARCH.

4817
04:15:46,000 --> 04:15:50,000
AS A FORMER ACADEMIC, I REALLY 

4818
04:15:50,000 --> 04:15:52,840
KNEW NOTHING ABOUT TRANSLATING 

4819
04:15:52,840 --> 04:15:56,600
FINDINGS TO A BUSINESS PLAN AND 

4820
04:15:56,600 --> 04:15:59,480
THAT'S THE GOAL OF THIS TO TAKE 

4821
04:15:59,480 --> 04:16:01,000
INNOVATION AND THE NIH 

4822
04:16:01,000 --> 04:16:02,760
INVESTIGATORS WHO ARE INNOVATING

4823
04:16:02,760 --> 04:16:05,920
AND GIVE THEM RESOURCES TO BOTH 

4824
04:16:05,920 --> 04:16:08,120
VALIDATE AND ADVANCE THEIR 

4825
04:16:08,120 --> 04:16:08,680
DISCOVERIES TO TRANSLATE TO 

4826
04:16:08,680 --> 04:16:15,240
PATIENT CARE.

4827
04:16:15,240 --> 04:16:17,320
I WANT TO DEVELOP RELATIONSHIPS 

4828
04:16:17,320 --> 04:16:19,680
WITH STRATEGIC PARTNERS AND 

4829
04:16:19,680 --> 04:16:22,040
BUILD OPPORTUNITIES FOR THEM TO 

4830
04:16:22,040 --> 04:16:22,800
FURTHER THEIR PROGRESS 

4831
04:16:22,800 --> 04:16:25,760
DEVELOPMENT EFFORTS.

4832
04:16:25,760 --> 04:16:29,880
IT ALLOWS THEM TO APPLY FOR 

4833
04:16:29,880 --> 04:16:31,880
EMERGENCY USE AUTHORIZATION, 

4834
04:16:31,880 --> 04:16:34,440
WHICH IN TURN ALLOWS PRODUCTS TO

4835
04:16:34,440 --> 04:16:37,480
MOVE MORE QUICKLY TO 

4836
04:16:37,480 --> 04:16:47,680
TRANSLATION.

4837
04:16:52,240 --> 04:16:55,240
SOME ARE MOVING TOWARDS FDA EUA 

4838
04:16:55,240 --> 04:16:55,520
APPROVAL.

4839
04:16:55,520 --> 04:16:59,120
THE FIRST IS AT THE UNIVERSITY 

4840
04:16:59,120 --> 04:16:59,760
OF CALIFORNIA SAN DIEGO FROM 

4841
04:16:59,760 --> 04:17:01,800
JANE BURNS.

4842
04:17:01,800 --> 04:17:05,440
HER TEAM IS USING RNA PROTEIN 

4843
04:17:05,440 --> 04:17:06,920
ANTIBODY AND CLINICAL PARAMETERS

4844
04:17:06,920 --> 04:17:09,920
TO PREDICT REGRESSION TO SEVERE 

4845
04:17:09,920 --> 04:17:10,960
COVID AND MIS-C.

4846
04:17:10,960 --> 04:17:14,720
THEY TOOK ADVANTAGE OF A LONG 

4847
04:17:14,720 --> 04:17:16,880
ONGOING COLLABORATION WITH THE 

4848
04:17:16,880 --> 04:17:20,520
U.K. AND REMEMBER IT WAS FIRST 

4849
04:17:20,520 --> 04:17:21,560
RECOGNIZED IN THE U.K.

4850
04:17:21,560 --> 04:17:27,800
IT WAS A HEAD START THERE.

4851
04:17:27,800 --> 04:17:38,280
AS WELL AS A U.S. COHORT AND 

4852
04:17:41,360 --> 04:17:42,920
THERE'S CARE TO DISTINGUISH 

4853
04:17:42,920 --> 04:17:45,080
BETWEEN MIS-C OR RELATED 

4854
04:17:45,080 --> 04:17:47,000
PEDIATRIC CONDITION KNOWN AS 

4855
04:17:47,000 --> 04:17:47,560
KAWASAKI DISEASE AND OTHER 

4856
04:17:47,560 --> 04:17:56,640
ILLNESSES.

4857
04:17:56,640 --> 04:17:58,000
AND THIS ALGORITHM IS BEING 

4858
04:17:58,000 --> 04:18:00,240
REVIEWED BY THE FDA.

4859
04:18:00,240 --> 04:18:03,480
IN THE MEANTIME, THEY ARE 

4860
04:18:03,480 --> 04:18:05,400
EXPANDING THEIR PREDICTED 

4861
04:18:05,400 --> 04:18:09,520
ALGORITHM WORK BY VALIDATING 

4862
04:18:09,520 --> 04:18:13,520
ACUTE PCR ASSAY THAT PREVIOUSLY 

4863
04:18:13,520 --> 04:18:14,520
IDENTIFIED THE SIGNATURE FOR 

4864
04:18:14,520 --> 04:18:16,320
MIS-C AND ARE USING THE PROTEINS

4865
04:18:16,320 --> 04:18:19,400
THAT CAN IDENTIFY MIS-C 

4866
04:18:19,400 --> 04:18:24,120
BILATERAL FLOW USING 

4867
04:18:24,120 --> 04:18:34,680
TECHNOLOGIES LIKE SOMAMERS AND 

4868
04:18:41,560 --> 04:18:51,600
ELISA.

4869
04:18:54,200 --> 04:18:55,560
THERE'S RESPONSE DIFFERENCES 

4870
04:18:55,560 --> 04:18:56,800
BETWEEN KAWASAKI DISEASE WHICH 

4871
04:18:56,800 --> 04:19:00,760
HAS SIMILAR FINDING TO MIS-C.

4872
04:19:00,760 --> 04:19:03,520
PROBABLY MIS-C HAS MORE 

4873
04:19:03,520 --> 04:19:06,400
PATHOLOGY SYSTEM AND MORE SEVERE

4874
04:19:06,400 --> 04:19:09,760
CARDIAC PATHOLOGY IN TERMS OF 

4875
04:19:09,760 --> 04:19:11,640
HYPERTENSION AND THE NEED FOR 

4876
04:19:11,640 --> 04:19:11,960
REPRESSERS.

4877
04:19:11,960 --> 04:19:14,720
THEY DID THEIR INITIAL STUDY 

4878
04:19:14,720 --> 04:19:18,480
BASED ON PUBLICLY AVAILABLE 

4879
04:19:18,480 --> 04:19:19,520
KAWASAKI DISEASE DATA SETS AND 

4880
04:19:19,520 --> 04:19:24,840
RECRUITED COHORTS.

4881
04:19:24,840 --> 04:19:26,720
MANY INVESTIGATORS ARE USING 

4882
04:19:26,720 --> 04:19:27,320
CHILDREN PRESENTING TO THE 

4883
04:19:27,320 --> 04:19:27,800
EMERGENCY ROOM AS THEIR 

4884
04:19:27,800 --> 04:19:37,960
CONTROLS.

4885
04:19:40,600 --> 04:19:43,840
IN MIS-C AND OTHERS THERE WERE 

4886
04:19:43,840 --> 04:19:47,840
UPREGULATION OF INTERLEUKIN 15 

4887
04:19:47,840 --> 04:19:49,840
AND PATHWAYS.

4888
04:19:49,840 --> 04:19:51,760
THEY SHOWED MANY SIMILAR 

4889
04:19:51,760 --> 04:19:54,600
MOLECULAR MARKERS IN KAWASAKI 

4890
04:19:54,600 --> 04:19:58,240
DISEASE AND MIS-C BUT THE 

4891
04:19:58,240 --> 04:19:59,840
HYPERINFLAMMATORY RESPONSE WAS 

4892
04:19:59,840 --> 04:20:01,120
HIGHER IN MIS-C.

4893
04:20:01,120 --> 04:20:03,880
THEY'VE IDENTIFIED SOME OF THE 

4894
04:20:03,880 --> 04:20:04,320
PATHWAYS.

4895
04:20:04,320 --> 04:20:09,960
THIS IS LINKED DIRECTLY TO 

4896
04:20:09,960 --> 04:20:14,320
MECHANISM TREATMENT-BASED 

4897
04:20:14,320 --> 04:20:20,640
RECOMMENDATIONS TO TREAT WITH 

4898
04:20:20,640 --> 04:20:22,840
ANAKINRR AND INFLIXIMAB.

4899
04:20:22,840 --> 04:20:24,640
I WANTED TO HIGHLIGHT THE BAYLOR

4900
04:20:24,640 --> 04:20:26,280
COLLEGE OF MEDICINE THEY'RE 

4901
04:20:26,280 --> 04:20:29,280
USING AN A.I. APPROACH TO LOOK 

4902
04:20:29,280 --> 04:20:30,920
AT RISK ASSESSMENT FOR COVID-19.

4903
04:20:30,920 --> 04:20:34,520
THEY LOOKED AT A RANGE OF 

4904
04:20:34,520 --> 04:20:35,680
MARKERS.

4905
04:20:35,680 --> 04:20:41,440
THEY HAD A 50,000 PARTICIPANT 

4906
04:20:41,440 --> 04:20:43,520
COHORT, HIGHLY DIVERSE AROUND 

4907
04:20:43,520 --> 04:20:43,800
TEXAS.

4908
04:20:43,800 --> 04:20:46,000
KIDS WITH COVID-19 AND THEN SOME

4909
04:20:46,000 --> 04:20:52,560
OF THEM HAD KNOWN MIS-C AND THEY

4910
04:20:52,560 --> 04:20:55,280
ENROLLED 400 PARTICIPANTS.

4911
04:20:55,280 --> 04:20:57,080
THE WHOLE PURPOSE WAS TO PREDICT

4912
04:20:57,080 --> 04:21:02,480
WHO WOULD BE AT RISK FOR MIS-C.

4913
04:21:02,480 --> 04:21:05,000
IF YOU LOOK AT THE IMAGE IN THE 

4914
04:21:05,000 --> 04:21:07,760
UPPER RIGHT THERE'S PALE PINK 

4915
04:21:07,760 --> 04:21:08,120
DOTS.

4916
04:21:08,120 --> 04:21:11,440
THOSE ARE COVID-19 KIDS WHO WERE

4917
04:21:11,440 --> 04:21:13,400
IN THE TRAINING SET.

4918
04:21:13,400 --> 04:21:17,360
THE DARK RED IS ACTUALLY KNOWN 

4919
04:21:17,360 --> 04:21:21,600
AND VALIDATED MIS-C CASES.

4920
04:21:21,600 --> 04:21:24,320
DARK PINK IS THE TRAINING MIS-C 

4921
04:21:24,320 --> 04:21:27,040
AND GRAYISH BLUE ON THE LEFT IS 

4922
04:21:27,040 --> 04:21:29,120
THE COVID-19 IN THE TRAINING 

4923
04:21:29,120 --> 04:21:29,960
SET.

4924
04:21:29,960 --> 04:21:34,000
YOU CAN SEE THAT THEIR ALGORITHM

4925
04:21:34,000 --> 04:21:36,080
SEPARATES BOTH ON THE TRAINING 

4926
04:21:36,080 --> 04:21:37,680
SET AND VALIDATION SET.

4927
04:21:37,680 --> 04:21:43,560
THE MIS-C CASES WHICH ARE IN 

4928
04:21:43,560 --> 04:21:44,360
DARK RED.

4929
04:21:44,360 --> 04:21:48,400
THEY'RE PREPARING AN EUA PACKAGE

4930
04:21:48,400 --> 04:21:52,800
BASED ON THEIR MARKERS WHICH ARE

4931
04:21:52,800 --> 04:21:54,280
NOT GENES BUT INFLAMMATORY 

4932
04:21:54,280 --> 04:22:02,040
CHEMOKINES AND SIGCYTOKINES AND 

4933
04:22:02,040 --> 04:22:10,600
LOOKING AT MET  -- MEDICAL 

4934
04:22:10,600 --> 04:22:11,920
RECORD AND CHEST X-RAY DATA.

4935
04:22:11,920 --> 04:22:17,520
THEY WERE ABLE TO HIGHLIGHT THE 

4936
04:22:17,520 --> 04:22:20,360
IMPACT ON SOCIO ECONOMIC AND 

4937
04:22:20,360 --> 04:22:21,160
RACE WITH DISEASE SEVERITY.

4938
04:22:21,160 --> 04:22:23,160
THEY ON THE BASIS OF THEIR 

4939
04:22:23,160 --> 04:22:25,520
STUDIES WERE ABLE TO SHOW 

4940
04:22:25,520 --> 04:22:27,480
NON-HISPANIC BLACK CHILDREN AND 

4941
04:22:27,480 --> 04:22:32,120
CHILDREN IN HIGH DEPRIVATION 

4942
04:22:32,120 --> 04:22:39,480
INDEX AREAS WERE MORE LIKELY TO 

4943
04:22:39,480 --> 04:22:44,720
REQUIRE SUPPORT.

4944
04:22:44,720 --> 04:22:46,720
WE'RE PROUD OF THIS BECAUSE IT'S

4945
04:22:46,720 --> 04:22:53,520
BEEN IN A LITTLE OVER UNDER A 

4946
04:22:53,520 --> 04:22:53,720
YEAR.

4947
04:22:53,720 --> 04:23:02,560
TREMENDOUS PROGRESS MADE.

4948
04:23:02,560 --> 04:23:04,920
I'M HOPING TO HAVE TIME FOR 

4949
04:23:04,920 --> 04:23:05,560
QUESTIONS BUT WANT HIGHLIGHT 

4950
04:23:05,560 --> 04:23:08,760
THREE FUTURE CHALLENGE.

4951
04:23:08,760 --> 04:23:12,320
THE FIRST IS VACCINATION.

4952
04:23:12,320 --> 04:23:19,920
NEXT WEEK DATA IS TO BE REVIEWED

4953
04:23:19,920 --> 04:23:24,440
FROM MODERNA AND PFIZER FOR 

4954
04:23:24,440 --> 04:23:26,440
CHILDREN 6 MONTHS TO 5 YEARS WHO

4955
04:23:26,440 --> 04:23:30,160
HAVE NOT BEEN VACCINATED AND 

4956
04:23:30,160 --> 04:23:31,760
THEY'RE PASSING THE VIRUS ALONG 

4957
04:23:31,760 --> 04:23:33,240
THOUGH NOT SYMPTOMATIC.

4958
04:23:33,240 --> 04:23:36,560
THE CHALLENGE IS WHEN THE 

4959
04:23:36,560 --> 04:23:40,760
VACCINE IS APPROVED.

4960
04:23:40,760 --> 04:23:44,720
RELATIVELY FEW CHILDREN ARE 

4961
04:23:44,720 --> 04:23:45,640
GETTING THE VACCINE AND IT'S NOT

4962
04:23:45,640 --> 04:23:47,960
A MATTER OF ACCESS.

4963
04:23:47,960 --> 04:23:49,640
I HAPPENED TO BE IN NEW YORK 

4964
04:23:49,640 --> 04:23:54,000
CITY LAST WEEKEND AND PLEASANTLY

4965
04:23:54,000 --> 04:23:56,080
SURPRISED EVERY FEW BLOCKS YOU 

4966
04:23:56,080 --> 04:23:57,040
HAVE MOBILE VANS THAT PROVIDE 

4967
04:23:57,040 --> 04:23:58,520
VACCINATION TO PEOPLE OF ALL 

4968
04:23:58,520 --> 04:23:58,920
AGES.

4969
04:23:58,920 --> 04:24:00,560
AT LEAST IN NEW YORK CITY YOU 

4970
04:24:00,560 --> 04:24:01,680
CAN WALK DOWN THE BLOCK AND YOU 

4971
04:24:01,680 --> 04:24:08,600
CAN GET VACCINATED.

4972
04:24:08,600 --> 04:24:10,320
THIS IS EXTREMELY TROUBLING 

4973
04:24:10,320 --> 04:24:13,160
BECAUSE WE HAVE THE VACCINES.

4974
04:24:13,160 --> 04:24:15,560
THEY ARE SAFE AND NOT 100% 

4975
04:24:15,560 --> 04:24:19,200
EFFECTIVE BUT EFFECTIVE IN 

4976
04:24:19,200 --> 04:24:22,760
REDUCING DISEASE AND CERTAINLY 

4977
04:24:22,760 --> 04:24:23,120
HOSPITALIZATION.

4978
04:24:23,120 --> 04:24:25,480
IT'S A LITTLE BIT BETTER FOR 

4979
04:24:25,480 --> 04:24:27,160
ADOLES

4980
04:24:27,160 --> 04:24:27,480
ADOLESCENTS.

4981
04:24:27,480 --> 04:24:29,920
STILL IT'S TROUBLING ONLY 58% OF

4982
04:24:29,920 --> 04:24:33,000
TEENAGERS ARE FULLY VACCINATED.

4983
04:24:33,000 --> 04:24:34,880
I'M HIGHLIGHTING THIS AS OUR 

4984
04:24:34,880 --> 04:24:38,960
FIRST CHALLENGE AND WE ALL NEED 

4985
04:24:38,960 --> 04:24:40,600
TO DO MORE TO ENCOURAGE 

4986
04:24:40,600 --> 04:24:41,200
VACCINATION IN THE PEDIATRIC 

4987
04:24:41,200 --> 04:24:51,400
POPULATION.

4988
04:25:03,080 --> 04:25:05,400
WE KNOW FROM PAST PANDEMICS THE 

4989
04:25:05,400 --> 04:25:08,880
POTENTIAL FOR NEURODEVELOPMENT 

4990
04:25:08,880 --> 04:25:09,920
CONSEQUENCES IN SUBSEQUENT 

4991
04:25:09,920 --> 04:25:10,440
GENERATION.

4992
04:25:10,440 --> 04:25:12,080
WHAT WE KNOW SO FAR IS IT ISN'T 

4993
04:25:12,080 --> 04:25:14,800
SEEM LIKE THERE'S A WHOLE LOT OF

4994
04:25:14,800 --> 04:25:16,400
TRANSMISSION OF THE VIRUS ACROSS

4995
04:25:16,400 --> 04:25:26,680
THE PLACENTA.

4996
04:25:27,760 --> 04:25:33,320
WE KNOW IT DEVELOPS IN A MOTHER 

4997
04:25:33,320 --> 04:25:36,360
WHO HAS SYSTEMIC INFLAMMATION 

4998
04:25:36,360 --> 04:25:39,400
CAN BE CONCERN AND THERE ARE 

4999
04:25:39,400 --> 04:25:44,120
PRELIMINARY REPORTS SUGGESTING A

5000
04:25:44,120 --> 04:25:46,400
CONNECTION BETWEEN PRENATAL SARS

5001
04:25:46,400 --> 04:25:47,920
COV2 AND DEVELOPMENT DISORDERS 

5002
04:25:47,920 --> 04:25:48,960
IN OFFSPRING.

5003
04:25:48,960 --> 04:25:53,320
WE NEED TO STUDY THIS MORE.

5004
04:25:53,320 --> 04:25:55,280
WE WOULD SUGGEST CELLULAR MODELS

5005
04:25:55,280 --> 04:25:57,240
OF FETAL BRAIN DEVELOPMENT COULD

5006
04:25:57,240 --> 04:25:59,000
HELP UNDERSTAND THE POTENTIAL 

5007
04:25:59,000 --> 04:26:01,600
SHORT AND LONG-TERM IMPACTS OF 

5008
04:26:01,600 --> 04:26:05,200
MATERNAL SARS COV2 INFECTION ON 

5009
04:26:05,200 --> 04:26:05,920
OFFSPRING AND PARTICULARLY THE 

5010
04:26:05,920 --> 04:26:08,720
LONG-TERM EFFECTS.

5011
04:26:08,720 --> 04:26:19,360
WE DON'T KNOW THE DIFFERENCES 

5012
04:26:21,600 --> 04:26:23,960
AND IF THERE'S A VULNERABLE 

5013
04:26:23,960 --> 04:26:34,480
WINDOW FOR THE FETUS AND CHILD.

5014
04:26:36,400 --> 04:26:39,240
THERE'S A PLEA TO INCLUDE 

5015
04:26:39,240 --> 04:26:44,480
PREGNANT AND LACTATING PEOPLE IN

5016
04:26:44,480 --> 04:26:44,720
RESEARCH.

5017
04:26:44,720 --> 04:26:47,160
THE 21st CENTURY CURES ACT 

5018
04:26:47,160 --> 04:26:48,960
SIGNED BY PRESIDENT OBAMA IN 

5019
04:26:48,960 --> 04:26:56,760
DECEMBER 2016 MANDATE THE ED THE

5020
04:26:56,760 --> 04:26:59,000
FORMATION OF A TASK FORCE 

5021
04:26:59,000 --> 04:27:01,520
SPECIFIC TO PREGNANT AND 

5022
04:27:01,520 --> 04:27:05,400
LACTATING WOMEN KNOWN AS PRGLAC.

5023
04:27:05,400 --> 04:27:07,440
THEY MET REGULARLY BETWEEN 2017 

5024
04:27:07,440 --> 04:27:09,480
AND 2020 WITH REPRESENTATION 

5025
04:27:09,480 --> 04:27:13,880
FROM MULTIPLE NIH INSTITUTES AND

5026
04:27:13,880 --> 04:27:15,520
CENTERS AND OFFICES OTHER 

5027
04:27:15,520 --> 04:27:17,520
FEDERAL PARTNERS AND INDUSTRY 

5028
04:27:17,520 --> 04:27:20,680
AND ACADEMIA AND ADVOCACY 

5029
04:27:20,680 --> 04:27:20,920
GROUPS.

5030
04:27:20,920 --> 04:27:25,520
WE ISSUED RECOMMENDATIONS TO THE

5031
04:27:25,520 --> 04:27:32,000
SECRETARY AND IN ADDITION TO 

5032
04:27:32,000 --> 04:27:35,240
DEVELOP PRACTICAL AND FEASIBLE 

5033
04:27:35,240 --> 04:27:36,000
IMPLEMENTATION PLAN.

5034
04:27:36,000 --> 04:27:37,560
OUR MANTRA WAS TO CHANGE THE 

5035
04:27:37,560 --> 04:27:39,560
CULTURE TO PROTECT PREGNANT 

5036
04:27:39,560 --> 04:27:40,840
PEOPLE THROUGH RESEARCH INSTEAD 

5037
04:27:40,840 --> 04:27:49,120
OF FROM RESEARCH.

5038
04:27:49,120 --> 04:27:54,360
AS WE WROTE IN JAMA THE 

5039
04:27:54,360 --> 04:27:55,320
IMPLEMENTATION PLAN WE HOPED 

5040
04:27:55,320 --> 04:27:57,040
WOULD GUIDE PEOPLE IN A 

5041
04:27:57,040 --> 04:28:02,240
SITUATION SUCH AS THIS WERE 

5042
04:28:02,240 --> 04:28:03,960
REALLY NOT RECOGNIZED AS A 

5043
04:28:03,960 --> 04:28:04,680
PUBLIC HEALTH EMERGENCY.

5044
04:28:04,680 --> 04:28:05,960
I'M NOT SAYING ANYTHING COULD 

5045
04:28:05,960 --> 04:28:07,240
HAVE BEEN DONE DIFFERENTLY BUT 

5046
04:28:07,240 --> 04:28:09,240
WHAT I AM SAYING IS WE NEED TO 

5047
04:28:09,240 --> 04:28:10,880
PLAN FOR THE INCLUSION OF 

5048
04:28:10,880 --> 04:28:13,120
PREGNANT AND LACTATING PEOPLE 

5049
04:28:13,120 --> 04:28:19,040
FOR THE NEXT PANDEMIC TO BE ABLE

5050
04:28:19,040 --> 04:28:29,520
TO EVALUATE AND WE SAW WHAT 

5051
04:28:31,880 --> 04:28:34,920
HAPPENED HERE WAS THERE WAS A 

5052
04:28:34,920 --> 04:28:37,320
VERY MIXED MESSAGING.

5053
04:28:37,320 --> 04:28:38,080
PREGNANT PEOPLE WERE CLEARLY 

5054
04:28:38,080 --> 04:28:41,240
GETTING SICKER THAN NON-PREGNANT

5055
04:28:41,240 --> 04:28:42,520
PEOPLE WITH COVID-19 AND 

5056
04:28:42,520 --> 04:28:43,080
YESTERDAY WE DIDN'T HAVE 

5057
04:28:43,080 --> 04:28:44,720
EVIDENCE TO REASSURE PEOPLE 

5058
04:28:44,720 --> 04:28:47,680
ABOUT THE SAFETY OF GETTING THE 

5059
04:28:47,680 --> 04:28:50,160
VACCINE AND ULTIMATELY WE RELIED

5060
04:28:50,160 --> 04:28:52,080
ON INFORMATION THAT WAS 

5061
04:28:52,080 --> 04:28:55,240
VOLUNTARILY REPORTED BY PREGNANT

5062
04:28:55,240 --> 04:28:57,360
PEOPLE TO THE VACCINE THAT WAS 

5063
04:28:57,360 --> 04:28:59,040
MAINTAINED BY THE C.D.C.

5064
04:28:59,040 --> 04:29:03,000
THAT'S A CHALLENGE IS HOW TO 

5065
04:29:03,000 --> 04:29:04,680
PREPARE FOR WHATEVER COMES NEXT 

5066
04:29:04,680 --> 04:29:07,480
AND HOW IT WILL AFFECT PREGNANT 

5067
04:29:07,480 --> 04:29:09,280
WOMEN AND THEIR FETUSES.

5068
04:29:09,280 --> 04:29:11,920
WITH THAT, THAT'S THEN OF MY 

5069
04:29:11,920 --> 04:29:12,400
FORMAL PRESENTATION.

5070
04:29:12,400 --> 04:29:14,760
I KNOW IT'S HARD FOR ME TO 

5071
04:29:14,760 --> 04:29:17,480
MULTITASK AND READ THE CHAT AT 

5072
04:29:17,480 --> 04:29:27,720
THE SAME TIME.

5073
04:29:29,720 --> 04:29:31,400
>> I DON'T SEE SPECIFIC 

5074
04:29:31,400 --> 04:29:31,840
QUESTIONS.

5075
04:29:31,840 --> 04:29:34,160
>> I HAVE ONE QUESTION.

5076
04:29:34,160 --> 04:29:34,960
>> GO AHEAD.

5077
04:29:34,960 --> 04:29:38,560
>> YOU PRESENTED SOME 

5078
04:29:38,560 --> 04:29:41,200
INFORMATION IN TERMS OF 

5079
04:29:41,200 --> 04:29:43,560
AFFECTING THE AVERAGE WOMAN'S 

5080
04:29:43,560 --> 04:29:44,440
DECISION ON VACCINATION AND HOW 

5081
04:29:44,440 --> 04:29:46,840
IT'S INVOLVED IN PUBLIC 

5082
04:29:46,840 --> 04:29:47,120
DISCOURSE.

5083
04:29:47,120 --> 04:29:48,440
HOW PERCEIVE GETTING THE 

5084
04:29:48,440 --> 04:29:52,000
INFORMATION OUT AS THE SCIENCE 

5085
04:29:52,000 --> 04:29:52,720
IS DEVELOPING?

5086
04:29:52,720 --> 04:29:53,960
IT'S A CHALLENGE BECAUSE THE 

5087
04:29:53,960 --> 04:29:56,680
SCIENCE IS DEVELOPING BUT IT'S 

5088
04:29:56,680 --> 04:30:01,880
SO TIMELY AND THE NEW YORK TIMES

5089
04:30:01,880 --> 04:30:07,600
ARTICLE PEOPLE ARE MAKING 

5090
04:30:07,600 --> 04:30:14,560
DECISIONS ABOUT LIFE.

5091
04:30:14,560 --> 04:30:16,720
AND THERE'S MECHANISMS TO DO 

5092
04:30:16,720 --> 04:30:17,040
THAT.

5093
04:30:17,040 --> 04:30:22,200
>> THAT'S A GREAT
QUESTION.

5094
04:30:22,200 --> 04:30:24,440
WE SEE OUR PRIMARY ROLE AS 

5095
04:30:24,440 --> 04:30:25,440
FIGURING OUT AND THROUGH THE 

5096
04:30:25,440 --> 04:30:27,320
LENS OF OUR POPULATIONS WHICH 

5097
04:30:27,320 --> 04:30:29,600
ARE CHILDREN, PREGNANT PEOPLE, 

5098
04:30:29,600 --> 04:30:33,040
PEOPLE OF REPRODUCTIVE AGE AND 

5099
04:30:33,040 --> 04:30:34,360
PEOPLE WITH INTELLECTUAL AND 

5100
04:30:34,360 --> 04:30:36,040
PHYSICAL DISABILITIES.

5101
04:30:36,040 --> 04:30:39,880
WITHIN THOSE POPULATIONS, WHERE 

5102
04:30:39,880 --> 04:30:40,960
ARE THE EVIDENCE GAPS?

5103
04:30:40,960 --> 04:30:42,280
THE MENSTRUATION QUESTION WAS A 

5104
04:30:42,280 --> 04:30:43,560
PERFECT EXAMPLE.

5105
04:30:43,560 --> 04:30:46,600
THERE WAS A HUGE GAP.

5106
04:30:46,600 --> 04:30:49,000
HUGE INTEREST ON THE PART OF THE

5107
04:30:49,000 --> 04:30:49,400
LAY PUBLIC.

5108
04:30:49,400 --> 04:30:52,000
WHAT COULD WE DO IN A SHORT TIME

5109
04:30:52,000 --> 04:30:52,800
FRAME.

5110
04:30:52,800 --> 04:30:54,960
GENERALLY IT'S SUPPLEMENTS IN 

5111
04:30:54,960 --> 04:30:55,560
THAT CASE.

5112
04:30:55,560 --> 04:30:58,040
IF THERE'S A REAL NEED TO GET 

5113
04:30:58,040 --> 04:30:59,240
INFORMATION OUT MONTHS TO YEARS 

5114
04:30:59,240 --> 04:31:07,560
WE'RE TALKING ABOUT SUPPLEMENTS.

5115
04:31:07,560 --> 04:31:09,280
WE FUND THE STUDIES AND GET THE 

5116
04:31:09,280 --> 04:31:10,600
EVIDENCE AND OUR OFFICE OF 

5117
04:31:10,600 --> 04:31:14,040
COMMUNICATION WORKING WITH THE 

5118
04:31:14,040 --> 04:31:15,520
NIH OFFICE OF COMMUNICATIONS 

5119
04:31:15,520 --> 04:31:17,200
GOES TO WORK ON SPREADING THE 

5120
04:31:17,200 --> 04:31:18,360
WORD AND THEY HAVE CLOSE 

5121
04:31:18,360 --> 04:31:20,520
RELATIONSHIPS WITH THE ADVOCACY 

5122
04:31:20,520 --> 04:31:21,440
GROUPS AND PROFESSIONAL 

5123
04:31:21,440 --> 04:31:21,960
SOCIETIES.

5124
04:31:21,960 --> 04:31:23,680
THROUGHOUT THE PANDEMIC WE'VE 

5125
04:31:23,680 --> 04:31:25,640
BEEN SPEAKING VERY REGULARLY 

5126
04:31:25,640 --> 04:31:28,720
WITH THE AMERICAN ACADEMY OF 

5127
04:31:28,720 --> 04:31:29,560
PEDIATRICS FOR EXAMPLE.

5128
04:31:29,560 --> 04:31:32,240
THE SOCIETY FOR WOMEN'S HEALTH 

5129
04:31:32,240 --> 04:31:32,520
RESEARCH.

5130
04:31:32,520 --> 04:31:34,480
THE SOCIETY FOR MATERNAL FETAL 

5131
04:31:34,480 --> 04:31:36,520
MEDICINE TO MAKE SURE THEY HAVE 

5132
04:31:36,520 --> 04:31:39,080
THE EVIDENCE ON THE STUDIES AND 

5133
04:31:39,080 --> 04:31:40,320
THEY ARE WORKING WITH US TO 

5134
04:31:40,320 --> 04:31:45,640
PROMOTE THE INFORMATION.

5135
04:31:45,640 --> 04:31:48,360
>> TARA, IF I CAN JUMP IN
FOR A 

5136
04:31:48,360 --> 04:31:52,120
SECOND, WHILE I AGREE WITH 

5137
04:31:52,120 --> 04:31:55,480
DIANA'S ASSESSMENT OF ONE WAY OF

5138
04:31:55,480 --> 04:31:56,960
GETTING THINGS DONE RAPIDLY IS 

5139
04:31:56,960 --> 04:31:59,040
THROUGH SUPPLEMENTS, BECAUSE OF 

5140
04:31:59,040 --> 04:32:01,440
THE 21st CENTURY CURES THE 

5141
04:32:01,440 --> 04:32:06,640
ABILITY TO DO OTHER TRANSACTIONS

5142
04:32:06,640 --> 04:32:08,120
WHICH IN EFFECT ALLOWS TO YOU 

5143
04:32:08,120 --> 04:32:13,520
BUILD YOUR TEAM DE NOVO AND DO 

5144
04:32:13,520 --> 04:32:15,720
REVIEW NOT BY THE TRADITIONAL 

5145
04:32:15,720 --> 04:32:19,720
PEER REVIEW SYSTEM BUT BY USING 

5146
04:32:19,720 --> 04:32:22,720
FEDERAL WORKFORCE FOLKS.

5147
04:32:22,720 --> 04:32:25,960
THAT'S ANOTHER WAY WHICH NIH IS 

5148
04:32:25,960 --> 04:32:26,760
INCREASINGLY TAKING ADVANTAGE 

5149
04:32:26,760 --> 04:32:30,200
OF.

5150
04:32:30,200 --> 04:32:40,720
I DON'T KNOW IF WE CAN SAY IT'S 

5151
04:32:41,320 --> 04:32:46,000
DARPA LIKE BUT IT'S ONE 

5152
04:32:46,000 --> 04:32:46,280
MECHANISM.

5153
04:32:46,280 --> 04:32:47,560
YOU DIDN'T HAVE THE BENEFIT OF 

5154
04:32:47,560 --> 04:32:52,520
HEARING EARLIER CONVERSATIONS.

5155
04:32:52,520 --> 04:33:03,160
THERE'S BEEN AAN ADMONISHMENT O 

5156
04:33:06,800 --> 04:33:09,760
YOU DID THING QUICKLY FOR COVID,

5157
04:33:09,760 --> 04:33:12,240
CAN DO IT FOR OTHER THINGS.

5158
04:33:12,240 --> 04:33:17,520
WE HAVE OTHER TOOLS AND 

5159
04:33:17,520 --> 04:33:27,760
TRANSACTIONS.

5160
04:33:50,320 --> 04:33:54,320
>> O.T.A. NOT EVERY
INSTITUTE 

5161
04:33:54,320 --> 04:33:57,520
HAS THEIR OWN O.T.A.

5162
04:33:57,520 --> 04:34:02,760
THERE'S SEVERAL INSTITUTES THE 

5163
04:34:02,760 --> 04:34:13,240
OFFICE OF THE DIRECTOR DOES.

5164
04:34:22,080 --> 04:34:26,720
>> THANK YOU FOR A SUPERB 

5165
04:34:26,720 --> 04:34:27,080
PRESENTATION.

5166
04:34:27,080 --> 04:34:29,520
VERY COMPREHENSIVE AND 

5167
04:34:29,520 --> 04:34:39,720
INFORMATIVE.

5168
04:34:40,840 --> 04:34:43,880
WE HEAR ABOUT ADOLESCENCE AND 

5169
04:34:43,880 --> 04:34:45,040
MENTAL HEALTH CRISIS AND IT'S 

5170
04:34:45,040 --> 04:34:47,240
DOMINATING AND A GREAT CONCERN 

5171
04:34:47,240 --> 04:34:49,440
IN TERMS OF YOUNGER AND OLDER 

5172
04:34:49,440 --> 04:34:49,720
ADOLESCENCE.

5173
04:34:49,720 --> 04:34:51,160
I'M WONDERING WHAT THE PORTFOLIO

5174
04:34:51,160 --> 04:34:53,480
LOOKS LIKE IN TERMS OF RESEARCH 

5175
04:34:53,480 --> 04:34:57,480
IN THAT AREA.

5176
04:34:57,480 --> 04:34:59,840
>> ACTUALLY NATIONAL
MENTAL 

5177
04:34:59,840 --> 04:35:02,040
HEALTH IS THE LEAD INSTITUTE FOR

5178
04:35:02,040 --> 04:35:04,120
ADOLESCENT MENTAL HEALTH ISSUES.

5179
04:35:04,120 --> 04:35:09,760
WE PARTNER WITH THEM ON A NUMBER

5180
04:35:09,760 --> 04:35:16,880
OF INITIATIVES.

5181
04:35:16,880 --> 04:35:19,520
IT'S SOMETHING WE'RE CONCERNED 

5182
04:35:19,520 --> 04:35:21,320
ABOUT AS WITH VIOLENCE IN 

5183
04:35:21,320 --> 04:35:22,320
SCHOOLS AND WE'RE ADDRESSING 

5184
04:35:22,320 --> 04:35:32,800
THESE VERY IMPORTANT ISSUES.

5185
04:35:37,040 --> 04:35:37,520
THE THINGS CHILDREN HAVE 

5186
04:35:37,520 --> 04:35:38,600
EXPERIENCE IN THE LAST TWO YEARS

5187
04:35:38,600 --> 04:35:39,280
ARE GOING TO RESONATE FOR MANY 

5188
04:35:39,280 --> 04:35:48,800
YEARS.

5189
04:35:48,800 --> 04:35:51,640
>> SHELLY, YOUR QUESTION.

5190
04:35:51,640 --> 04:35:52,840
WE MIGHT WRAP UP.

5191
04:35:52,840 --> 04:35:58,080
WE'RE HEADING INTO THE BREAK.

5192
04:35:58,080 --> 04:35:59,080
>> THANK YOU.

5193
04:35:59,080 --> 04:35:59,640
I ENJOYED THAT.

5194
04:35:59,640 --> 04:36:04,200
I WANTED TO CONGRATULATE YOU ON 

5195
04:36:04,200 --> 04:36:05,640
REPORTING ON THE NEGATIVE DATA 

5196
04:36:05,640 --> 04:36:07,920
WHICH WE DON'T OFTEN HEAR AND 

5197
04:36:07,920 --> 04:36:11,880
WAS GREAT TO HEAR THAT TO TRY TO

5198
04:36:11,880 --> 04:36:14,000
DISPEL MISINFORMATION ON OUR 

5199
04:36:14,000 --> 04:36:15,640
MINDS SO MUCH NOW.

5200
04:36:15,640 --> 04:36:17,440
I REALLY LIKE THAT AT THE 

5201
04:36:17,440 --> 04:36:18,000
BEGINNING.

5202
04:36:18,000 --> 04:36:20,040
THEN I HAD A QUESTION I THOUGHT 

5203
04:36:20,040 --> 04:36:24,480
YOU SAID IF I CAUGHT IT RIGHT 

5204
04:36:24,480 --> 04:36:26,200
WITH MIS-C I THOUGHT YOU SAID 

5205
04:36:26,200 --> 04:36:29,480
THERE'S A FOUR-GENE SIGNATURE 

5206
04:36:29,480 --> 04:36:35,120
COMING OUT IN THE SEQUENCING.

5207
04:36:35,120 --> 04:36:38,560
I WAS CURIOUS WHAT ARE THOSE 

5208
04:36:38,560 --> 04:36:44,320
FOUR GENES, SUPER CURIOUS IS 

5209
04:36:44,320 --> 04:36:46,520
THAT SEEN IN ADULT-LONG COVID 

5210
04:36:46,520 --> 04:36:49,120
AND I ALSO WANTED TO SAY I 

5211
04:36:49,120 --> 04:36:51,080
THOUGHT THE SUPPLEMENTS WERE 

5212
04:36:51,080 --> 04:36:51,960
AMAZING THEY'RE ACCOMPLISHING 

5213
04:36:51,960 --> 04:36:53,320
ALL THIS.

5214
04:36:53,320 --> 04:36:55,120
I KNOW YOU WANT TO BRING IN 

5215
04:36:55,120 --> 04:37:01,200
OTHER PEOPLE BUT TRULY AMAZING.

5216
04:37:01,200 --> 04:37:05,480
>> THANK YOU.

5217
04:37:05,480 --> 04:37:06,360
THOSE PARTICULAR SUPPLEMENTS 

5218
04:37:06,360 --> 04:37:07,200
WERE OKAY BECAUSE IT'S A 

5219
04:37:07,200 --> 04:37:15,240
SPECIALIZED AREA.

5220
04:37:15,240 --> 04:37:17,240
>> YOU CAN TELL ME LATER
OR PUT 

5221
04:37:17,240 --> 04:37:18,360
THEM IN THE CHAT IF IT'S 

5222
04:37:18,360 --> 04:37:18,960
INFLAMMATION OR OTHER THINGS 

5223
04:37:18,960 --> 04:37:24,360
COMING UP.

5224
04:37:24,360 --> 04:37:33,360
>> I DON'T THINK THE SAME
GENES 

5225
04:37:33,360 --> 04:37:34,920
HAVE BEEN STUDIED IN ADULTS.

5226
04:37:34,920 --> 04:37:35,400
IT'S CHILDREN.

5227
04:37:35,400 --> 04:37:37,480
>> GOT IT.

5228
04:37:37,480 --> 04:37:47,040
THANK YOU.

5229
04:37:47,040 --> 04:37:48,640
>> LARRY, BACK TO YOU TO
TAKE US

5230
04:37:48,640 --> 04:37:57,120
TO BREAK.

5231
04:37:57,120 --> 04:37:59,320
GREAT PRESENTATIONS, TONY, 

5232
04:37:59,320 --> 04:38:03,120
WALTER AND DIANA.

5233
04:38:03,120 --> 04:38:04,040
HOPEFULLY IT GIVES A GREATER 

5234
04:38:04,040 --> 04:38:07,080
FEEL FOR WHAT THE STATUS OF 

5235
04:38:07,080 --> 04:38:11,680
COVID RELATED AND OTHER MORE 

5236
04:38:11,680 --> 04:38:13,480
CHRONIC COVID-19 SEQUELAE.

5237
04:38:13,480 --> 04:38:24,000
WE'LL TAKE A SHORT BREAK NOW.

5238
04:39:09,920 --> 04:39:11,120
AS THOSE WHO ARE BEEN ON THE 

5239
04:39:11,120 --> 04:39:12,800
COMMITTEE KNOW WE HAVE A SERIES 

5240
04:39:12,800 --> 04:39:19,120
OF WORKING GROUPS THAT TACKLE 

5241
04:39:19,120 --> 04:39:29,600
PARTICULARLY VEXING PROBLEMS.

5242
04:39:30,600 --> 04:39:33,520
WE GET PEOPLE FOR MEMBERSHIP ON 

5243
04:39:33,520 --> 04:39:34,400
A COMMITTEE.

5244
04:39:34,400 --> 04:39:39,560
THE LUCKY INDIVIDUAL IN THIS 

5245
04:39:39,560 --> 04:39:50,040
CASE WAS BARBARA WOLD AND A 

5246
04:39:55,120 --> 04:39:57,600
ROBUST REPORT WAS CREATED UNDER 

5247
04:39:57,600 --> 04:40:01,160
BARBARA'S LEADERSHIP.

5248
04:40:01,160 --> 04:40:02,840
WE HAVE DISCUSSED THE REPORT 

5249
04:40:02,840 --> 04:40:04,440
THOROUGHLY IN PREVIOUS SESSIONS.

5250
04:40:04,440 --> 04:40:07,160
THIS WILL BE AN UPDATE ON SOME 

5251
04:40:07,160 --> 04:40:10,760
OF THE IMPLEMENTATION EFFORTS.

5252
04:40:10,760 --> 04:40:11,760
AS YOU MIGHT IMAGINE FOR 

5253
04:40:11,760 --> 04:40:17,360
SOMETHING AS BROAD AS THIS TOPIC

5254
04:40:17,360 --> 04:40:19,680
IT'S A TEAM SPORT AND SEVERAL 

5255
04:40:19,680 --> 04:40:27,200
OFFICES WITHIN NIH ARE ENGAGED.

5256
04:40:27,200 --> 04:40:37,720
YOU THE OFFICE OF EXTRAMURAL 

5257
04:40:46,960 --> 04:40:57,360
RESEARCH HAS TAKEN THE LEAD.

5258
04:40:59,760 --> 04:41:01,960
>> AS MENTIONED THIS IS AN

5259
04:41:01,960 --> 04:41:03,200
UPDATE ON WHAT HAS COME OUT OF 

5260
04:41:03,200 --> 04:41:08,200
THE WORK THAT WAS LED BY THE 

5261
04:41:08,200 --> 04:41:09,080
WORKING GROUP.

5262
04:41:09,080 --> 04:41:11,800
I WANT TO THANK DR. WOLD AND HER

5263
04:41:11,800 --> 04:41:16,960
COLLEAGUES FROM OUTSIDE AND 

5264
04:41:16,960 --> 04:41:20,560
INSIDE GOVERNMENT FOR THIS 

5265
04:41:20,560 --> 04:41:20,800
PROJECT.

5266
04:41:20,800 --> 04:41:28,800
THE REPORT WAS RELEASED LAST 

5267
04:41:28,800 --> 04:41:38,920
JUNE.

5268
04:41:39,640 --> 04:41:42,160
THE REPORT LAST JUNE IDENTIFIED 

5269
04:41:42,160 --> 04:41:45,240
FIVE THEMES, IMPROVING STUDY 

5270
04:41:45,240 --> 04:41:48,800
DESIGN AND ACADEMIC RIGOR AND 

5271
04:41:48,800 --> 04:41:52,680
BIAS IN REPORTING IMPROVING 

5272
04:41:52,680 --> 04:41:55,520
METHODOLOGIC AND REPORTS AND 

5273
04:41:55,520 --> 04:42:00,120
EVALUATING EFFECTIVENESS AND 

5274
04:42:00,120 --> 04:42:01,400
COST WITHIN THEMES THERE WERE A 

5275
04:42:01,400 --> 04:42:02,760
NUMBER OF RECOMMENDATIONS.

5276
04:42:02,760 --> 04:42:09,520
I WON'T GO EACH ONE BY ONE I'LL 

5277
04:42:09,520 --> 04:42:11,120
REVIEW SOME OF THE EFFORTS TAKEN

5278
04:42:11,120 --> 04:42:15,560
PLACE SINCE THE REPORT WAS 

5279
04:42:15,560 --> 04:42:16,360
RELEASED.

5280
04:42:16,360 --> 04:42:18,840
I WANT TO THANK MY COLLEAGUE THE

5281
04:42:18,840 --> 04:42:20,320
DEPUTY DIRECTOR OF THE OFFICE OF

5282
04:42:20,320 --> 04:42:22,080
EXTRAMURAL RESEARCH FOR HELPING 

5283
04:42:22,080 --> 04:42:32,440
LEAD THESE EFFORTS.

5284
04:42:49,360 --> 04:42:56,840
WE'LL TRY TO DEVELOP A SHORT, 

5285
04:42:56,840 --> 04:42:57,880
INTERMEDIATE AND LONG-TERM 

5286
04:42:57,880 --> 04:42:59,080
RESPONSE TO THE REPORT'S 

5287
04:42:59,080 --> 04:42:59,440
RECOMMENDATIONS.

5288
04:42:59,440 --> 04:43:02,360
I'LL TALK ABOUT A CONCEPT 

5289
04:43:02,360 --> 04:43:04,920
CLEARANCE THAT CAME FROM THE 

5290
04:43:04,920 --> 04:43:08,800
OFFICE OF RESEARCH 

5291
04:43:08,800 --> 04:43:19,200
INFRASTRUCTURE PROGRAMS.

5292
04:43:20,280 --> 04:43:21,240
IN THE COURSE OF GOING THROUGH 

5293
04:43:21,240 --> 04:43:23,280
THE REPORT, WE REALIZED WE HAVE 

5294
04:43:23,280 --> 04:43:26,720
A NUMBER OF EXISTING RESOURCES 

5295
04:43:26,720 --> 04:43:29,360
AT NIH THAT ANSWERED A NUMBER OF

5296
04:43:29,360 --> 04:43:32,800
THE RECOMMENDATIONS BUT ARE NOT 

5297
04:43:32,800 --> 04:43:34,880
WELL MARKETED OR WELL 

5298
04:43:34,880 --> 04:43:35,280
PUBLICIZED.

5299
04:43:35,280 --> 04:43:38,240
THERE MAY BE OPPORTUNITIES TO 

5300
04:43:38,240 --> 04:43:39,640
LEVERAGE THEM TO A BETTER DEGREE

5301
04:43:39,640 --> 04:43:40,600
THAN WE CURRENTLY ARE.

5302
04:43:40,600 --> 04:43:42,200
I THEN WANT TO TAKE A STEP BACK 

5303
04:43:42,200 --> 04:43:45,640
AND TALK ABOUT ONGOING EFFORTS 

5304
04:43:45,640 --> 04:43:48,560
TO ENHANCE RIGOR WRIT LARGE NOT 

5305
04:43:48,560 --> 04:43:52,600
JUST WITH ANIMAL AS WELL AS PEER

5306
04:43:52,600 --> 04:43:53,200
REVIEW.

5307
04:43:53,200 --> 04:43:54,280
I'LL SEND SHORT-TERM 

5308
04:43:54,280 --> 04:43:54,800
CONSIDERATIONS FOR THE 

5309
04:43:54,800 --> 04:44:05,000
DISCUSSION.

5310
04:44:14,120 --> 04:44:17,400
WE WILL LOOK AT ANIMAL MODELS IN

5311
04:44:17,400 --> 04:44:18,160
BIOMEDICAL RESEARCH.

5312
04:44:18,160 --> 04:44:20,120
THIS WAS OPENED FOR APPLICATIONS

5313
04:44:20,120 --> 04:44:21,880
AS OF FEBRUARY.

5314
04:44:21,880 --> 04:44:24,280
APPLICATIONS WILL CONTINUE TO BE

5315
04:44:24,280 --> 04:44:28,400
ACCEPTED THROUGH MARCH OF 2024.

5316
04:44:28,400 --> 04:44:31,360
THE GOALS ARE TO DEVELOP OR TO 

5317
04:44:31,360 --> 04:44:33,240
FUND EXPLORATORY DEVELOPMENT AND

5318
04:44:33,240 --> 04:44:37,480
HIGHLY INNOVATIVE PROJECTS FOR 

5319
04:44:37,480 --> 04:44:38,640
TOOLS AND RESOURCES FOR 

5320
04:44:38,640 --> 04:44:40,680
VALIDATING ANIMAL MODELS AND FOR

5321
04:44:40,680 --> 04:44:42,760
ENHANCING THE RIGOR, 

5322
04:44:42,760 --> 04:44:44,160
REPRODUCIBILITY AND 

5323
04:44:44,160 --> 04:44:46,000
TRANSLATABILITY OF ANIMAL 

5324
04:44:46,000 --> 04:44:46,280
RESEARCH.

5325
04:44:46,280 --> 04:44:49,640
THE POINT IS SINCE THIS IS AN OD

5326
04:44:49,640 --> 04:44:52,880
PROGRAM THE PROPOSALS HAVE TO 

5327
04:44:52,880 --> 04:44:55,600
ADDRESS INTEREST OF MULTIPLE NIH

5328
04:44:55,600 --> 04:44:59,240
I.C.s OR ORGAN SYSTEMS OR IN 

5329
04:44:59,240 --> 04:45:01,520
SOME WAY APPLICABLE TO MORE THAN

5330
04:45:01,520 --> 04:45:09,480
JUST THE INTEREST OF ONE I.C.

5331
04:45:09,480 --> 04:45:12,520
AND THERE'S BEEN A PRESENTATION 

5332
04:45:12,520 --> 04:45:14,200
OF CONCEPT CLEARANCE TO THE 

5333
04:45:14,200 --> 04:45:16,720
SO-CALLED COUNCIL OF COUNCILS.

5334
04:45:16,720 --> 04:45:19,520
WHAT THEY WANT TO DO IS TAKE THE

5335
04:45:19,520 --> 04:45:22,880
PROGRAM TIE HIGHER LEVEL.

5336
04:45:22,880 --> 04:45:25,960
BY FUNDING MERITORIOUS PROPOSALS

5337
04:45:25,960 --> 04:45:27,560
THROUGH A VARIETY OF FUND 

5338
04:45:27,560 --> 04:45:27,960
MECHANISM.

5339
04:45:27,960 --> 04:45:33,480
ONE IS A TWO-YEAR R21, 

5340
04:45:33,480 --> 04:45:36,000
RELATIVELY SMALL, SHORT-TERM 

5341
04:45:36,000 --> 04:45:44,480
EXPLORATORY GRANT AND R10s AND 

5342
04:45:44,480 --> 04:45:47,760
R24s OR U24s IS A COOPERATIVE 

5343
04:45:47,760 --> 04:45:51,640
VERSION OF R24.

5344
04:45:51,640 --> 04:45:53,920
GRANTS THAT SUPPORT RESOURCES AS

5345
04:45:53,920 --> 04:45:54,480
WELL AS SMALL BUSINESS.

5346
04:45:54,480 --> 04:45:57,120
THE IDEA IS TO FUND PROJECTS ON 

5347
04:45:57,120 --> 04:45:59,360
A GRANULAR LEVEL AND FOR A 

5348
04:45:59,360 --> 04:46:00,360
LONGER PERIOD OF TIME.

5349
04:46:00,360 --> 04:46:03,080
THE PROPOSED PROJECTS HAVE TO 

5350
04:46:03,080 --> 04:46:04,240
DEMONSTRATE HOW THE PROPOSED 

5351
04:46:04,240 --> 04:46:05,680
RESOURCES OR TECHNOLOGIES WILL 

5352
04:46:05,680 --> 04:46:07,520
IMPACT RIGOR AND REPRODUCIBILITY

5353
04:46:07,520 --> 04:46:09,400
OF ANIMAL STUDIES.

5354
04:46:09,400 --> 04:46:12,800
THIS WAS PRESENTED TO COUNCIL OF

5355
04:46:12,800 --> 04:46:14,040
COUNCILS MAY 19.

5356
04:46:14,040 --> 04:46:19,400
THERE WILL BE FOAs COMING OUT IN

5357
04:46:19,400 --> 04:46:23,080
THE NEAR FUTURE.

5358
04:46:23,080 --> 04:46:24,640
THERE'S GOING TO BE PLANNED 

5359
04:46:24,640 --> 04:46:35,160
WORKSHOPS FROM SYMPOSIA AND ONE 

5360
04:46:35,720 --> 04:46:37,920
WE'RE EXCITE ABOUT AND THE 

5361
04:46:37,920 --> 04:46:41,480
OFFICE OF PORTFOLIO ANALYSIS DID

5362
04:46:41,480 --> 04:46:43,560
AN ANALYSIS OF ANIMAL MODELS 

5363
04:46:43,560 --> 04:46:45,600
USED IN COVID RESEARCH.

5364
04:46:45,600 --> 04:46:47,680
THAT'S GOING LEAD TO A WORKSHOP 

5365
04:46:47,680 --> 04:46:49,720
LATER IN THE YEAR ON ANIMAL 

5366
04:46:49,720 --> 04:46:51,640
MODELS AND RELATED MODELS FOR 

5367
04:46:51,640 --> 04:46:53,360
COVID RESEARCH AND LESSONS 

5368
04:46:53,360 --> 04:46:53,600
LEARNED.

5369
04:46:53,600 --> 04:47:04,080
THERE'LL BE MENTION IN THE 

5370
04:47:06,160 --> 04:47:08,400
REPORT AND THERE'LL BE A 

5371
04:47:08,400 --> 04:47:11,520
WORKSHOP ON RIGOR AND 

5372
04:47:11,520 --> 04:47:14,320
REPRODUCIBILITY AND ASSESSMENT 

5373
04:47:14,320 --> 04:47:16,000
OF EQUIPMENT INSTRUMENT, 

5374
04:47:16,000 --> 04:47:16,880
EXTRAMURAL CONSTRUCTION 

5375
04:47:16,880 --> 04:47:17,200
PROJECTS.

5376
04:47:17,200 --> 04:47:19,600
THE INSTITUTE FOR LABORATORY 

5377
04:47:19,600 --> 04:47:26,520
ANIMAL RESEARCH OR ILAR, THEY 

5378
04:47:26,520 --> 04:47:29,240
PUT OUT A GUIDE ON ANIMAL 

5379
04:47:29,240 --> 04:47:32,200
WELFARE WILL HAVE A PROJECT ON 

5380
04:47:32,200 --> 04:47:33,640
EFFECTIVE COMMUNICATION ABOUT 

5381
04:47:33,640 --> 04:47:34,200
SCIENTIFIC RESEARCH THAT 

5382
04:47:34,200 --> 04:47:37,400
REQUIRES WORK WITH ANIMALS.

5383
04:47:37,400 --> 04:47:39,640
THERE WAS AN EXPLICIT 

5384
04:47:39,640 --> 04:47:40,240
RECOMMENDATION IN THE REPORT 

5385
04:47:40,240 --> 04:47:43,960
THAT WE NEED TO TAKE STEPS TO 

5386
04:47:43,960 --> 04:47:45,880
INFORM THE PUBLIC, EDUCATE THE 

5387
04:47:45,880 --> 04:47:49,920
PUBLIC, ENGAGE THE PUBLIC ON THE

5388
04:47:49,920 --> 04:47:52,520
IMPORTANCE OF ANIMAL RESEARCH.

5389
04:47:52,520 --> 04:47:54,920
NIH IS PLEASED WE'LL BE HELPING 

5390
04:47:54,920 --> 04:47:56,800
TO SUPPORT THIS PARTICULAR 

5391
04:47:56,800 --> 04:47:59,760
EFFORT.

5392
04:47:59,760 --> 04:48:01,680
IN THE COURSE OF OUR INTERNAL 

5393
04:48:01,680 --> 04:48:07,040
DELIBERATIONS ON THE WORKING 

5394
04:48:07,040 --> 04:48:08,520
GROUP REPORT, WE NOTED THERE ARE

5395
04:48:08,520 --> 04:48:15,080
A NUMBER OF RESOURCES WE ALREADY

5396
04:48:15,080 --> 04:48:17,760
HAVE OR ALREADY FUNDED THAT 

5397
04:48:17,760 --> 04:48:18,360
ANSWER RECOMMENDATIONS THAT 

5398
04:48:18,360 --> 04:48:19,600
PERHAPS COULD BE MARKETED 

5399
04:48:19,600 --> 04:48:19,840
BETTER.

5400
04:48:19,840 --> 04:48:21,600
HERE'S TWO EXAMPLES.

5401
04:48:21,600 --> 04:48:24,440
A CLEARING HOUSE FOR TRAINING 

5402
04:48:24,440 --> 04:48:26,840
MODULES ON RIGOR THAT COMES FROM

5403
04:48:26,840 --> 04:48:29,400
PROJECTS FUNDED BY NIGMS.

5404
04:48:29,400 --> 04:48:31,640
WE HAVE ONE ON STATISTICAL TOPIC

5405
04:48:31,640 --> 04:48:34,080
FOR REPRODUCIBLE ANIMAL RESEARCH

5406
04:48:34,080 --> 04:48:36,200
AND ANOTHER ON CONTROLS IN 

5407
04:48:36,200 --> 04:48:37,080
ANIMAL STUDIES FOR RIGOR AND 

5408
04:48:37,080 --> 04:48:39,920
REPRODUCIBILITY.

5409
04:48:39,920 --> 04:48:42,720
WE HAVE ON OUR OFFICE OF 

5410
04:48:42,720 --> 04:48:45,760
EXTRAMURAL RESEARCH WEBSITE A 

5411
04:48:45,760 --> 04:48:47,920
DEDICATED WEB PAGE ON RIGOR AND 

5412
04:48:47,920 --> 04:48:50,840
REPRODUCIBILITY AND INCLUDED IN 

5413
04:48:50,840 --> 04:48:53,600
THERE WE HAVE A SEPARATE PAGE ON

5414
04:48:53,600 --> 04:48:59,000
RESOURCES, ONE OF THE RESOURCES 

5415
04:48:59,000 --> 04:49:01,760
WE DO LET THE PUBLIC KNOW ABOUT 

5416
04:49:01,760 --> 04:49:03,880
IS A U.K.-BASED RESOURCE 

5417
04:49:03,880 --> 04:49:04,640
AVAILABLE FOR FREE.

5418
04:49:04,640 --> 04:49:06,040
THERE'S SOME FUNDING AGENCIES 

5419
04:49:06,040 --> 04:49:11,680
AROUND THE WORLD THAT REQUIRE 

5420
04:49:11,680 --> 04:49:14,440
ITS USE.

5421
04:49:14,440 --> 04:49:16,520
IT'S QUITE POWERFUL.

5422
04:49:16,520 --> 04:49:19,360
A WAY TO PRODUCE GRAPHICS AND SO

5423
04:49:19,360 --> 04:49:21,760
ONE OF THE THINGS WE COULD DO 

5424
04:49:21,760 --> 04:49:22,800
WHILE WE'RE NOT REQUIRING ITS 

5425
04:49:22,800 --> 04:49:24,800
USE IS TO DO A BETTER JOB OF 

5426
04:49:24,800 --> 04:49:26,360
LETTING THE PUBLIC KNOW THIS 

5427
04:49:26,360 --> 04:49:29,440
EXISTS AND WE STRONGLY ENCOURAGE

5428
04:49:29,440 --> 04:49:30,520
RESEARCHERS TO INCLUDE THIS AS 

5429
04:49:30,520 --> 04:49:35,640
THEY PREPARE THEIR PROPOSALS.

5430
04:49:35,640 --> 04:49:36,840
THERE'S ANOTHER INTERESTING 

5431
04:49:36,840 --> 04:49:38,800
RESOURCE WHICH IS SUPPORTED BY 

5432
04:49:38,800 --> 04:49:43,000
THE NIEA THE ALZHEIMER'S 

5433
04:49:43,000 --> 04:49:45,960
PRECLINICAL EFFICACY DATABASE.

5434
04:49:45,960 --> 04:49:49,200
IT'S A DATABASE THEY SUPPORT IN 

5435
04:49:49,200 --> 04:49:52,040
WHICH THE PUBLICATIONS THAT COME

5436
04:49:52,040 --> 04:49:55,920
OUT OF NIA FUNDED ALZHEIMER'S 

5437
04:49:55,920 --> 04:49:59,120
RESEARCH CAN BE GRADED ON A 

5438
04:49:59,120 --> 04:50:02,680
VARIETY OF RIGOR AND 

5439
04:50:02,680 --> 04:50:05,320
TRANSPARENCY CRITERIA.

5440
04:50:05,320 --> 04:50:08,240
FOR EXAMPLE, THEY LOOK AT A 

5441
04:50:08,240 --> 04:50:09,360
VARIETY OF DIFFERENT ITEMS SO 

5442
04:50:09,360 --> 04:50:11,760
THE ITEMS ON THE RIGHT MIGHT BE 

5443
04:50:11,760 --> 04:50:14,040
GENERAL RIGOR ITEMS LIKE 

5444
04:50:14,040 --> 04:50:16,200
BLINDING, RANDOMIZATION, SEX AS 

5445
04:50:16,200 --> 04:50:19,280
A BIOLOGICAL VARIABLE AND THE 

5446
04:50:19,280 --> 04:50:25,480
ITEMS IN THE BLUE MIGHT BE THOSE

5447
04:50:25,480 --> 04:50:31,440
ITEMS THAT ARE MORE RELATED TO 

5448
04:50:31,440 --> 04:50:32,520
SPECIFIC EXPERIMENTAL WORK AND 

5449
04:50:32,520 --> 04:50:34,640
THE ITEMS IN BLUE ARE HIGH RATES

5450
04:50:34,640 --> 04:50:37,280
OF REPORTING AND THE ITEMS IN 

5451
04:50:37,280 --> 04:50:38,840
RED ARE WHAT WE DISCUSSED IN THE

5452
04:50:38,840 --> 04:50:40,760
RACE AND REPORTING ARE 

5453
04:50:40,760 --> 04:50:42,360
RELATIVELY LOW.

5454
04:50:42,360 --> 04:50:47,480
HERE'S AN EXAMPLE OF ONE 

5455
04:50:47,480 --> 04:50:51,760
PARTICULAR STUDY THAT WAS 

5456
04:50:51,760 --> 04:50:53,720
REPORTED OUT IN 2021 AND A 

5457
04:50:53,720 --> 04:50:54,960
NUMBER OF CRITERIA BY WHICH THE 

5458
04:50:54,960 --> 04:50:56,960
STUDY IS GRADED.

5459
04:50:56,960 --> 04:51:00,320
GREEN IS REPORTED AND RED WOULD 

5460
04:51:00,320 --> 04:51:03,080
MEAN THOSE ITEMS WERE NOT 

5461
04:51:03,080 --> 04:51:04,360
PROPERLY REPORTED.

5462
04:51:04,360 --> 04:51:06,120
I'M JUST PRESENTING THIS AS ONE 

5463
04:51:06,120 --> 04:51:06,640
EXAMPLE.

5464
04:51:06,640 --> 04:51:10,520
ONE MIGHT THINK ABOUT OTHER 

5465
04:51:10,520 --> 04:51:11,280
MEASURES THAT COULD BE 

5466
04:51:11,280 --> 04:51:12,640
CONSIDERED AS WELL NOT INCLUDED 

5467
04:51:12,640 --> 04:51:14,680
IN HERE.

5468
04:51:14,680 --> 04:51:17,480
WHEN WE DISCUSSED THIS WITH I.C.

5469
04:51:17,480 --> 04:51:20,240
DIRECTORS, ONE OF THE KEY 

5470
04:51:20,240 --> 04:51:22,080
DISCUSSION POINTS IS THIS KIND 

5471
04:51:22,080 --> 04:51:24,800
OF RESOURCE IS POTENTIALLY QUITE

5472
04:51:24,800 --> 04:51:26,320
VALUABLE.

5473
04:51:26,320 --> 04:51:27,800
IT HELPS US UNDERSTAND HOW 

5474
04:51:27,800 --> 04:51:29,320
RIGOROUS AND TRANSPARENCY OUR 

5475
04:51:29,320 --> 04:51:32,800
WORK MAY BE AND WE WOULD 

5476
04:51:32,800 --> 04:51:33,960
ENCOURAGE OTHER I.C.s AND 

5477
04:51:33,960 --> 04:51:36,960
PROGRAMS TO CONSIDER DOING 

5478
04:51:36,960 --> 04:51:46,160
SOMETHING LIKE THIS.

5479
04:51:46,160 --> 04:51:49,920
I WANT TO TALK ABOUT ONGOING 

5480
04:51:49,920 --> 04:51:50,840
RIGOR EFFORTS THAT DON'T 

5481
04:51:50,840 --> 04:51:53,320
NECESSARILY APPLY TO ANIMAL 

5482
04:51:53,320 --> 04:51:56,800
RESEARCH BUT NONETHELESS ARE 

5483
04:51:56,800 --> 04:51:57,080
IMPORTANT.

5484
04:51:57,080 --> 04:51:58,560
THE CENTER FOR SCIENTIFIC REVIEW

5485
04:51:58,560 --> 04:51:59,920
BUT TOGETHER ONE OF THEIR OWN 

5486
04:51:59,920 --> 04:52:03,280
WORKING GROUPS AND ASKED THEM TO

5487
04:52:03,280 --> 04:52:05,520
DEVELOP AN APPROACH TO 

5488
04:52:05,520 --> 04:52:06,160
SIMPLIFYING REVIEW CRITERIA.

5489
04:52:06,160 --> 04:52:08,560
ONE PROBLEM WE'RE ALL FAMILIAR 

5490
04:52:08,560 --> 04:52:12,800
WITH IS THAT THERE ARE MANY 

5491
04:52:12,800 --> 04:52:13,680
REVIEW CRITERIA.

5492
04:52:13,680 --> 04:52:16,080
MANY ITEMS PEER REVIEW ARE BEING

5493
04:52:16,080 --> 04:52:17,880
ASKED TO LOOK AT.

5494
04:52:17,880 --> 04:52:19,480
THE RESULT IS LESS TIME MAY BE 

5495
04:52:19,480 --> 04:52:21,480
SPENT BY PEER REVIEWERS TALKING 

5496
04:52:21,480 --> 04:52:24,640
ABOUT THE RIGOR AND APPROACH OF 

5497
04:52:24,640 --> 04:52:27,960
A PARTICULAR PROPOSAL AS OPPOSED

5498
04:52:27,960 --> 04:52:30,560
TO A VARIETY OF OTHER TOPICS.

5499
04:52:30,560 --> 04:52:32,040
I HAVE THE LINK ON THE SLIDE OF 

5500
04:52:32,040 --> 04:52:35,360
A PUBLIC REPORT THAT WAS PUT 

5501
04:52:35,360 --> 04:52:36,120
OUT.

5502
04:52:36,120 --> 04:52:38,360
THEY'RE PROPOSING SIMPLIFYING 

5503
04:52:38,360 --> 04:52:39,560
REVIEW CRITERIA FROM THE CURRENT

5504
04:52:39,560 --> 04:52:41,520
FIVE TO THREE.

5505
04:52:41,520 --> 04:52:43,240
THERE'S A LOT MORE THAN THIS.

5506
04:52:43,240 --> 04:52:47,400
THE KEY POINT HERE IS MORE 

5507
04:52:47,400 --> 04:52:49,880
EFFORT SHOULD BE CONCENTRATED ON

5508
04:52:49,880 --> 04:52:52,880
FOCUSSING ON THE IMPORTANCE OF 

5509
04:52:52,880 --> 04:52:54,640
THE SCIENCE AND FEASIBILITY AND 

5510
04:52:54,640 --> 04:52:56,080
RIGOR OF SCIENCE AND LESS ON A 

5511
04:52:56,080 --> 04:52:58,320
VARIETY OF OTHER AREAS THAT MAY 

5512
04:52:58,320 --> 04:52:59,960
BE IMPORTANT AND ARE IMPORTANT 

5513
04:52:59,960 --> 04:53:02,880
BUT NONETHELESS MAY BE BETTER 

5514
04:53:02,880 --> 04:53:05,920
HANDLED BY NIH STAFF.

5515
04:53:05,920 --> 04:53:08,800
THIS IS YOU MIGHT CALL A BRIEF 

5516
04:53:08,800 --> 04:53:09,880
SNEAK PREVIEW.

5517
04:53:09,880 --> 04:53:17,800
THE WORK THE CSR ADVISORY 

5518
04:53:17,800 --> 04:53:19,200
COUNCIL WORK GROUP HAS UNDER 

5519
04:53:19,200 --> 04:53:20,760
GONE WORK AND NIH COMMITTEES 

5520
04:53:20,760 --> 04:53:21,760
LOOKED AT THIS AND CONTINUE TO 

5521
04:53:21,760 --> 04:53:22,480
WORK THROUGH IT.

5522
04:53:22,480 --> 04:53:28,120
WE PLAN TO BRING IT TO YOU IN 

5523
04:53:28,120 --> 04:53:32,680
DECEMBER FOR FURTHER DISCUSSION.

5524
04:53:32,680 --> 04:53:34,040
THIS IS A WAY BY WHICH PEER 

5525
04:53:34,040 --> 04:53:37,520
REVIEW CAN DO A BETTER JOB AND 

5526
04:53:37,520 --> 04:53:39,200
RAISE THE LEVEL OF FEASIBILITY 

5527
04:53:39,200 --> 04:53:40,920
AND RIGOR OVER AND ABOVE WHAT 

5528
04:53:40,920 --> 04:53:44,960
THEY'RE DOING NOW.

5529
04:53:44,960 --> 04:53:46,760
WE THINK ANOTHER COMPONENT OF 

5530
04:53:46,760 --> 04:53:48,600
RIGOR AND TRANSPARENCY IS 

5531
04:53:48,600 --> 04:53:49,320
THROUGH DATA.

5532
04:53:49,320 --> 04:53:50,080
THAT'S SOMETHING WE'LL BE 

5533
04:53:50,080 --> 04:53:51,040
DISCUSSING TOMORROW.

5534
04:53:51,040 --> 04:53:57,320
THERE'LL BE A FAIRLY EXTENSIVE 

5535
04:53:57,320 --> 04:53:57,760
DISCUSSION.

5536
04:53:57,760 --> 04:53:59,520
WE ALSO SEE THIS AS A CRITICAL 

5537
04:53:59,520 --> 04:54:05,760
COMPONENT OF ENHANCING RIGOR AND

5538
04:54:05,760 --> 04:54:08,080
TRANSPARENCY.

5539
04:54:08,080 --> 04:54:10,040
THE NINDS IS NOW FUNDING AN 

5540
04:54:10,040 --> 04:54:13,080
EFFORT TO ENHANCE TRAINING IN 

5541
04:54:13,080 --> 04:54:14,400
EXPERIMENTAL RIGOR.

5542
04:54:14,400 --> 04:54:18,600
SO THIS IS A PROGRAM WHICH IS 

5543
04:54:18,600 --> 04:54:20,160
CALLED METER.

5544
04:54:20,160 --> 04:54:26,120
THESE ANNOUNCEMENTS ARE 

5545
04:54:26,120 --> 04:54:27,880
CURRENTLY AVAILABLE THEY'RE 

5546
04:54:27,880 --> 04:54:30,120
PUTTING TOGETHER A COORDINATING 

5547
04:54:30,120 --> 04:54:32,400
CENTER AND GOING TO BE MULTIPLE 

5548
04:54:32,400 --> 04:54:35,040
OTHER EFFORTS TO PUT TOGETHER A 

5549
04:54:35,040 --> 04:54:39,440
VARIETY OF ONLINE RESOURCES TO 

5550
04:54:39,440 --> 04:54:40,720
TEACH THE BIOMEDICAL RESEARCH 

5551
04:54:40,720 --> 04:54:42,120
COMMUNITY FUNDAMENTAL PRINCIPLES

5552
04:54:42,120 --> 04:54:46,120
OF RIGOR, THE IDEA IS TO DEVELOP

5553
04:54:46,120 --> 04:54:48,720
AN INNOVATIVE ONLINE EDUCATIONAL

5554
04:54:48,720 --> 04:54:50,960
RESOURCE THAT CAN BE USED BY AN 

5555
04:54:50,960 --> 04:54:53,440
ARRAY OF LEARNING ENVIRONMENTS 

5556
04:54:53,440 --> 04:54:55,400
AND THIS WOULD INCLUDE ANIMAL 

5557
04:54:55,400 --> 04:54:56,360
RESEARCH GIVEN IT'S A LARGE PART

5558
04:54:56,360 --> 04:55:02,920
OF OUR PORTFOLIO.

5559
04:55:02,920 --> 04:55:04,400
ALSO, NINDS HAS RECENTLY POSTED 

5560
04:55:04,400 --> 04:55:07,960
A WORKSHOP ON CATALYZING 

5561
04:55:07,960 --> 04:55:09,680
COMMUNITIES OF RESEARCH RIGOR 

5562
04:55:09,680 --> 04:55:10,040
CHAMPIONS.

5563
04:55:10,040 --> 04:55:12,720
I'D POINT OUT ONE OF THE 

5564
04:55:12,720 --> 04:55:19,400
CO-CHAIRS IS DR. KIMMER IS A 

5565
04:55:19,400 --> 04:55:21,360
MEMBER OF OUR WORKING GROUP.

5566
04:55:21,360 --> 04:55:23,160
THERE'S A VIDEOCAST.

5567
04:55:23,160 --> 04:55:29,120
IT WAS A TERRIFIC WORKSHOP.

5568
04:55:29,120 --> 04:55:31,320
IT'S WORTH TAKING A LOOK AT.

5569
04:55:31,320 --> 04:55:33,880
WHAT I'D LIKE TO CONCLUDE WITH 

5570
04:55:33,880 --> 04:55:35,160
IS STIMULATE DISCUSSION ABOUT 

5571
04:55:35,160 --> 04:55:40,960
THREE ITEMS WE'RE THINKING 

5572
04:55:40,960 --> 04:55:43,240
ABOUT.

5573
04:55:43,240 --> 04:55:44,240
WE'D LIKE YOUR FEEDBACK AS TO 

5574
04:55:44,240 --> 04:55:46,240
WHETHER OR NOT WE SHOULD GO DOWN

5575
04:55:46,240 --> 04:55:56,480
THESE ROUTES.

5576
04:55:57,600 --> 04:55:58,800
THERE'S REPORTING ON THE ARRIVE 

5577
04:55:58,800 --> 04:55:59,120
GUIDELINES.

5578
04:55:59,120 --> 04:56:02,680
THEY'VE BEEN OUT FOR A WHILE BUT

5579
04:56:02,680 --> 04:56:03,160
THEY'VE BEEN REVISED.

5580
04:56:03,160 --> 04:56:05,880
THE IDEA OF THE ARRIVE 

5581
04:56:05,880 --> 04:56:08,080
GUIDELINES IS TO ENHANCE THE 

5582
04:56:08,080 --> 04:56:09,680
DEGREE OF REPORTING AND 

5583
04:56:09,680 --> 04:56:11,400
HOPEFULLY BY DOING THAT 

5584
04:56:11,400 --> 04:56:13,800
STIMULATE MORE RIGOROUS AND 

5585
04:56:13,800 --> 04:56:14,880
TRANSPARENT WORK.

5586
04:56:14,880 --> 04:56:16,240
THERE ARE MANY JOURNALS AND BY 

5587
04:56:16,240 --> 04:56:18,000
MANY JOURNALS I MEAN PROBABLY 

5588
04:56:18,000 --> 04:56:20,080
HUNDREDS OF JOURNALS THAT 

5589
04:56:20,080 --> 04:56:21,640
ENCOURAGE OR EVEN REQUIRE THE 

5590
04:56:21,640 --> 04:56:24,720
USE OF THE ARRIVE GUIDELINES.

5591
04:56:24,720 --> 04:56:26,880
WE'RE THINKING OF PUTTING OUT A 

5592
04:56:26,880 --> 04:56:28,320
GUIDE NOTICE IN WHICH WE 

5593
04:56:28,320 --> 04:56:30,920
STRONGLY ENCOURAGE RESEARCHERS 

5594
04:56:30,920 --> 04:56:32,160
SUPPORTED BY NIH GRANTS TO USE 

5595
04:56:32,160 --> 04:56:34,880
THE ARRIVE GUIDELINES WHEN THEY 

5596
04:56:34,880 --> 04:56:37,520
ARE REPORTING THEIR RESULTS IN A

5597
04:56:37,520 --> 04:56:39,880
PEER REVIEW VENUE.

5598
04:56:39,880 --> 04:56:41,520
OUR QUESTION FOR YOU IS WHETHER 

5599
04:56:41,520 --> 04:56:44,760
OR NOT YOU THINK THIS IS A GOOD 

5600
04:56:44,760 --> 04:56:45,000
IDEA.

5601
04:56:45,000 --> 04:56:46,240
IF YOU THINK IT IS, WE CAN GO 

5602
04:56:46,240 --> 04:56:50,080
AHEAD AND PUT THIS TOGETHER AND 

5603
04:56:50,080 --> 04:56:56,240
PUBLISH IT AND MARKET IT.

5604
04:56:56,240 --> 04:56:58,320
THERE'S A NUMBER OF 

5605
04:56:58,320 --> 04:56:59,320
RECOMMENDATIONS ABOUT ENHANCING 

5606
04:56:59,320 --> 04:57:00,720
THE COLLABORATION OF 

5607
04:57:00,720 --> 04:57:06,160
STATISTICIANS AND RESEARCHERS 

5608
04:57:06,160 --> 04:57:09,680
WHO WORK WITH ANIMAL MODEL.

5609
04:57:09,680 --> 04:57:12,040
ONE THOUGHT IS PUT OUT FOAs 

5610
04:57:12,040 --> 04:57:13,080
FUNDING STATISTICAL CORE TO 

5611
04:57:13,080 --> 04:57:15,080
SUPPORT ANIMAL RESEARCHERS AND 

5612
04:57:15,080 --> 04:57:19,960
UNDER RESOURCED INSTITUTIONS.

5613
04:57:19,960 --> 04:57:21,280
WE HOPE AT WELL RESOURCED 

5614
04:57:21,280 --> 04:57:24,720
INSTITUTIONS THIS IS ALREADY 

5615
04:57:24,720 --> 04:57:27,720
HAPPENING AND THERE ARE 

5616
04:57:27,720 --> 04:57:30,800
COLLABORAT

5617
04:57:30,800 --> 04:57:31,520
COLLABORATIONS BETWEEN 

5618
04:57:31,520 --> 04:57:33,760
STATISTICIANS AND ANIMAL 

5619
04:57:33,760 --> 04:57:35,040
RESEARCHERS BUT MAYBE AT LESS 

5620
04:57:35,040 --> 04:57:36,920
RESOURCED INSTITUTIONS MAYBE WE 

5621
04:57:36,920 --> 04:57:47,440
CAN STIMULATE THIS KIND OF WORK 

5622
04:57:54,000 --> 04:57:54,040
.

5623
04:57:54,040 --> 04:58:04,040
THE FINAL ITEM IS WE WERE 

5624
04:58:04,040 --> 04:58:05,920
IMPRESSED BY WORK BEING DONE AND

5625
04:58:05,920 --> 04:58:09,200
IT MADE US THINK OF A PRIZE IN 

5626
04:58:09,200 --> 04:58:10,400
WHICH WE WOULD HIGHLIGHT 

5627
04:58:10,400 --> 04:58:11,720
EXEMPLARY WORK AND STUDY DESIGN 

5628
04:58:11,720 --> 04:58:13,480
AND ANALYSIS IN ANIMAL RESEARCH.

5629
04:58:13,480 --> 04:58:17,320
IT WOULD BE A NON-MONETARY PRIZE

5630
04:58:17,320 --> 04:58:18,840
BUT NONETHELESS WOULD BE 

5631
04:58:18,840 --> 04:58:21,440
PRESTIGIOUS AND GO THROUGH A 

5632
04:58:21,440 --> 04:58:23,800
RIGOROUS VETTING PROCESS AT THE 

5633
04:58:23,800 --> 04:58:26,760
NIH AND WOULD BE AN NIH TO 

5634
04:58:26,760 --> 04:58:28,960
INSPIRE AND ENCOURAGE PEOPLE TO 

5635
04:58:28,960 --> 04:58:32,720
RAISE THE LEVEL OF THEIR OWN 

5636
04:58:32,720 --> 04:58:33,920
WORK.

5637
04:58:33,920 --> 04:58:35,720
I WILL STOP HERE AND HAPPY TO 

5638
04:58:35,720 --> 04:58:44,560
HEAR YOUR THOUGHTS OR COMMENTS.

5639
04:58:44,560 --> 04:58:48,560
THANKS, VERY MUCH, MIKE.

5640
04:58:48,560 --> 04:58:54,360
WE OWE BARBARA THE FIRST WORD ON

5641
04:58:54,360 --> 04:58:54,880
OR COMMENTS.

5642
04:58:54,880 --> 04:58:57,840
>> TO NEW MEMBERS, IF THEY
COME 

5643
04:58:57,840 --> 04:58:59,520
TO YOU TO DO ONE OF THESE BEFORE

5644
04:58:59,520 --> 04:59:00,520
YOU COME TO YOUR FIRST MEETING, 

5645
04:59:00,520 --> 04:59:10,680
WATCH OUT.

5646
04:59:11,120 --> 04:59:12,040
LARRY AND MIKE THANK YOU FOR 

5647
04:59:12,040 --> 04:59:12,800
PUTTING THESE IN MOTION.

5648
04:59:12,800 --> 04:59:13,520
IT'S GREAT IT SEE THEM COME TO 

5649
04:59:13,520 --> 04:59:23,080
REALITY.

5650
04:59:23,080 --> 04:59:24,760
QUESTIONS OPPOSED ON IMMEDIATE 

5651
04:59:24,760 --> 04:59:27,280
ACTION ITEMS, NUMBER 3, THE 

5652
04:59:27,280 --> 04:59:29,800
PRIZE TO HIGHLIGHT TERRIFIC WORK

5653
04:59:29,800 --> 04:59:37,520
IN THIS VEIN IS A NO-BRAINER.

5654
04:59:37,520 --> 04:59:40,120
PLEASE GO FORWARD TO MAKE IT 

5655
04:59:40,120 --> 04:59:41,000
HAPPEN.

5656
04:59:41,000 --> 04:59:44,600
WITH RESPECT TO FUNDING 

5657
04:59:44,600 --> 04:59:49,320
STATISTICAL CORES THAT IS 

5658
04:59:49,320 --> 04:59:59,880
SOMETHING WE HAD ENTHUSIASM FOR 

5659
05:00:02,640 --> 05:00:05,320
SEEDING IT AT UNDER RESOURCED 

5660
05:00:05,320 --> 05:00:07,360
INSTITUTIONS GOES TOWARDS 

5661
05:00:07,360 --> 05:00:09,280
LARRY'S PROBLEM AND MORE THE 

5662
05:00:09,280 --> 05:00:11,120
REASON TO BE ENTHUSED.

5663
05:00:11,120 --> 05:00:13,960
AND WITH RESPECT TO THE ARRIVE 

5664
05:00:13,960 --> 05:00:18,960
GUIDELINES, MY PERSONAL TAKE IS 

5665
05:00:18,960 --> 05:00:21,880
THAT WAS SOMETHING THAT HAD A 

5666
05:00:21,880 --> 05:00:28,480
LARGE DEGREE OF IMPETUS BROADLY 

5667
05:00:28,480 --> 05:00:30,840
AND WITH THE CURRENT VERSION OF 

5668
05:00:30,840 --> 05:00:36,400
ARRIVE IT WAS THE ESSENTIAL 10 

5669
05:00:36,400 --> 05:00:36,720
ENCOURAGED.

5670
05:00:36,720 --> 05:00:38,240
IT'S A LITTLE BIT DIFFERENT IF 

5671
05:00:38,240 --> 05:00:40,240
YOU GIVE A BROAD MANDATE TO THE 

5672
05:00:40,240 --> 05:00:42,280
ENTIRETY OF ARRIVE WHICH IS A 

5673
05:00:42,280 --> 05:00:46,840
GOOD THING BUT WON'T NECESSARILY

5674
05:00:46,840 --> 05:00:50,480
LAND WITH AS MUCH EFFICACY ON 

5675
05:00:50,480 --> 05:00:51,600
THE BROAD COMMUNITY.

5676
05:00:51,600 --> 05:00:53,520
THAT'S A GOOD RECOMMENDATION.

5677
05:00:53,520 --> 05:00:54,720
OTHER PEOPLE BOTH ON THE 

5678
05:00:54,720 --> 05:00:58,200
COMMITTEE AND OFF JUMP IN.

5679
05:00:58,200 --> 05:01:00,640
>> THANKS, BARBARA.

5680
05:01:00,640 --> 05:01:01,440
OTHER COMMENTS OR QUESTIONS 

5681
05:01:01,440 --> 05:01:11,720
PEOPLE MAY HAVE?

5682
05:01:16,320 --> 05:01:18,400
>> THERE'S A COMMENT IN
THE 

5683
05:01:18,400 --> 05:01:18,600
CHAT.

5684
05:01:18,600 --> 05:01:20,120
LOOKS LIKE INNOVATION IS NO 

5685
05:01:20,120 --> 05:01:21,280
LONGER A CONSIDERATION.

5686
05:01:21,280 --> 05:01:22,560
IT'S STILL A CONSIDERATION.

5687
05:01:22,560 --> 05:01:25,240
THEY'RE TAKING THE FIVE CRITERIA

5688
05:01:25,240 --> 05:01:27,760
AND NARROWING IT DOWN TO THREE.

5689
05:01:27,760 --> 05:01:31,360
ONE OF THE THREE IS THE WORK 

5690
05:01:31,360 --> 05:01:31,640
IMPORTANT.

5691
05:01:31,640 --> 05:01:33,920
THAT WOULD CAPTURE SIGNIFICANCE 

5692
05:01:33,920 --> 05:01:34,960
AND INNOVATION.

5693
05:01:34,960 --> 05:01:36,760
I DID NOT DO JUSTICE TO THE WORK

5694
05:01:36,760 --> 05:01:38,200
DONE HERE.

5695
05:01:38,200 --> 05:01:43,200
THERE'S BEEN A TREMENDOUS AMOUNT

5696
05:01:43,200 --> 05:01:53,720
OF WORK DONE THE LINK IS ON THE 

5697
05:01:54,520 --> 05:01:55,080
SLIDE DECK BUT WE CAN PUT IT IN 

5698
05:01:55,080 --> 05:02:03,200
THE CHAT.

5699
05:02:03,200 --> 05:02:09,240
WE'LL SPEND SIGNIFICANT TIME AT 

5700
05:02:09,240 --> 05:02:11,400
ACD IN SEPTEMBER WITH MORE 

5701
05:02:11,400 --> 05:02:14,240
DETAIL AND GET FEEDBACK THEN.

5702
05:02:14,240 --> 05:02:17,040
>> JUDITH.

5703
05:02:17,040 --> 05:02:18,760
>> I APPLAUD THIS AS WELL.

5704
05:02:18,760 --> 05:02:21,080
I THINK IT'S AN IMPORTANT 

5705
05:02:21,080 --> 05:02:24,240
DIRECTION FOR NIH TO GO TO 

5706
05:02:24,240 --> 05:02:26,280
BOLSTER THE RIGOR AND 

5707
05:02:26,280 --> 05:02:28,800
REPRODUCIBILITY FOR NOT ONLY NIH

5708
05:02:28,800 --> 05:02:30,680
BUT SOCIETY.

5709
05:02:30,680 --> 05:02:36,560
WE NEED TO HAVE EVERYBODY ON OUR

5710
05:02:36,560 --> 05:02:41,440
SIDE.

5711
05:02:41,440 --> 05:02:43,360
ALSO FOSTERING RIGOROUS SCIENCE.

5712
05:02:43,360 --> 05:02:48,400
I LIKE THE CHANGE IN PEER REVIEW

5713
05:02:48,400 --> 05:02:50,400
BUT COULD SEE IT COULD BE DONE 

5714
05:02:50,400 --> 05:02:50,600
POORLY.

5715
05:02:50,600 --> 05:02:56,000
I'M WONDERING WHAT THE PLAN IS 

5716
05:02:56,000 --> 05:02:57,880
FOR IMPLEMENTING IT AND WORKING 

5717
05:02:57,880 --> 05:03:01,480
WITH THE CSR AND STUDY SECTIONS 

5718
05:03:01,480 --> 05:03:02,320
TO MAKE SURE IT'S IMPLEMENTED IN

5719
05:03:02,320 --> 05:03:11,320
THE RIGHT WAY.

5720
05:03:11,320 --> 05:03:13,240
RIGHT WAY MEANS THE BEST 

5721
05:03:13,240 --> 05:03:13,560
SCIENCE.

5722
05:03:13,560 --> 05:03:16,440
I THINK YOU ASKED US TO GIVE 

5723
05:03:16,440 --> 05:03:21,280
FEEDBACK ON ALL THE DIFFERENT 

5724
05:03:21,280 --> 05:03:23,520
THINGS YOU SUGGESTED YOU SUGGEST

5725
05:03:23,520 --> 05:03:26,520
LOTS OF THINGS AND MAY BE 

5726
05:03:26,520 --> 05:03:30,040
WORTHWHILE HAVING ANOTHER 

5727
05:03:30,040 --> 05:03:34,800
SESSION OR SMALLER SESSION OR 

5728
05:03:34,800 --> 05:03:36,040
MAYBE E-MAIL EXCHANGE BECAUSE 

5729
05:03:36,040 --> 05:03:37,600
THERE WAS TOO MUCH TO SAY THIS 

5730
05:03:37,600 --> 05:03:43,840
LOOKS GREAT AT LEAST FOR ME.

5731
05:03:43,840 --> 05:03:47,160
>> SO FOLLOW-UP MAY BE
DONE BEST

5732
05:03:47,160 --> 05:03:52,560
ELECTRONICALLY AND COLLECTED AND

5733
05:03:52,560 --> 05:03:56,160
WE'D PROVIDE A SUMMARY AT THE 

5734
05:03:56,160 --> 05:03:57,280
NEXT ACD MEETING SO EVERYBODY 

5735
05:03:57,280 --> 05:04:03,880
UNDERSTANDS WHAT FEEDBACK WE 

5736
05:04:03,880 --> 05:04:05,960
RECEIVED.

5737
05:04:05,960 --> 05:04:08,880
THE DECEMBER MEETING WILL LOOK 

5738
05:04:08,880 --> 05:04:12,520
THROUGH THIS CAREFULLY FOR THE 

5739
05:04:12,520 --> 05:04:15,600
REASONS YOU ANTICIPATED, JUDITH.

5740
05:04:15,600 --> 05:04:17,080
IMPLEMENTED CORRECTLY THIS COULD

5741
05:04:17,080 --> 05:04:18,600
BE A GREAT STEP FORWARD BUT 

5742
05:04:18,600 --> 05:04:21,880
NEEDS TO BE IMPLEMENTED 

5743
05:04:21,880 --> 05:04:24,000
CORRECTLY TO BE VALUE-ADDED.

5744
05:04:24,000 --> 05:04:27,960
THE ONLY WAY THAT WILL HAPPEN IS

5745
05:04:27,960 --> 05:04:31,680
IF WE SOCIALIZE IT AND WORK WITH

5746
05:04:31,680 --> 05:04:34,640
THE DIFFERENT GROUPS THIS WILL 

5747
05:04:34,640 --> 05:04:38,280
AFFECT AND GET BUY-IN, FEEDBACK,

5748
05:04:38,280 --> 05:04:39,880
ETCETERA FROM THE VARIOUS 

5749
05:04:39,880 --> 05:04:44,760
GROUPS.

5750
05:04:44,760 --> 05:04:45,720
A LOT OF WORK HAS BEEN DONE 

5751
05:04:45,720 --> 05:04:47,920
ALREADY BUT AS WE GO MORE 

5752
05:04:47,920 --> 05:04:49,720
BROADLY WITH THIS, THAT PIECE 

5753
05:04:49,720 --> 05:04:50,760
CAN'T BE OVERLOOKED.

5754
05:04:50,760 --> 05:04:56,960
THANKS FOR THOSE COMMENTS.

5755
05:04:56,960 --> 05:05:03,880
OTHER COMMENTS OR QUESTIONS?

5756
05:05:03,880 --> 05:05:14,400
>> I WANT TO COME BACK TO
THE 

5757
05:05:15,560 --> 05:05:17,320
ISSUE OF RESOURCES.

5758
05:05:17,320 --> 05:05:20,120
THE ARRIVE RESOURCES ARE HELPFUL

5759
05:05:20,120 --> 05:05:24,440
BUT WHAT COMES UP PARTICULARLY 

5760
05:05:24,440 --> 05:05:26,280
FOR LOTS OF PEOPLE WHETHER 

5761
05:05:26,280 --> 05:05:27,240
RESOURCED OR NOT IS STATISTICAL 

5762
05:05:27,240 --> 05:05:37,480
ANALYSIS PLAN.

5763
05:05:40,680 --> 05:05:42,280
YOUR SUPPORT FOR STATISTICAL 

5764
05:05:42,280 --> 05:05:42,880
GROUPS IS GREAT.

5765
05:05:42,880 --> 05:05:53,440
WHAT I'D LIKE TO SEE IS IF YOU 

5766
05:06:02,040 --> 05:06:04,800
WANT TO DO THIS EXPERIMENT TALK 

5767
05:06:04,800 --> 05:06:07,560
TO OUR DATA SCIENTIST AND 

5768
05:06:07,560 --> 05:06:09,800
STATISTICIANS WE CAN HELP.

5769
05:06:09,800 --> 05:06:15,440
SOMETHING AROUND THE ARRIVE MAY 

5770
05:06:15,440 --> 05:06:18,440
BE A PLACE OR ALTERNATIVE 

5771
05:06:18,440 --> 05:06:21,080
RELATED AND SOMEWHERE WHERE AN 

5772
05:06:21,080 --> 05:06:22,720
UNDERGRADUATE OR GRADUATE 

5773
05:06:22,720 --> 05:06:27,880
STUDENT WHEREVER THEY ARE CAN 

5774
05:06:27,880 --> 05:06:38,320
GAIN STATISTICAL SUPPORT.

5775
05:06:45,240 --> 05:06:47,400
>> ARE YOU SUGGESTING NIH
SHOULD

5776
05:06:47,400 --> 05:06:50,960
PROVIDE A RESOURCE?

5777
05:06:50,960 --> 05:06:54,680
>> IMAGINE A CENTER
FOCUSSED ON 

5778
05:06:54,680 --> 05:06:57,520
I U54 CENTER FOCUSSED ON RIGOR 

5779
05:06:57,520 --> 05:07:03,920
AND REPRODUCIBILITY AND THEY 

5780
05:07:03,920 --> 05:07:04,720
OFFER THAT TO A LARGE COMMUNITY 

5781
05:07:04,720 --> 05:07:12,760
OF RESEARCHERS.

5782
05:07:12,760 --> 05:07:19,280
THEY GO A LONG WAY IN PROMOTING 

5783
05:07:19,280 --> 05:07:20,280
A BROADER PORTFOLIO OF RESEARCH 

5784
05:07:20,280 --> 05:07:22,760
ACROSS MULTIPLE INSTITUTIONS AND

5785
05:07:22,760 --> 05:07:26,560
REACHING A BROADER AUDIENCE OF 

5786
05:07:26,560 --> 05:07:28,080
RESEARCHERS JUST AN IDEA.

5787
05:07:28,080 --> 05:07:30,040
>> CAN I ASK A FOLLOW-UP 

5788
05:07:30,040 --> 05:07:31,200
QUESTION TO THAT OF WHAT YOUR 

5789
05:07:31,200 --> 05:07:33,720
ACTUALLY SUGGEST.

5790
05:07:33,720 --> 05:07:40,160
THE DREAM WOULD BE A 9-1-1 STATS

5791
05:07:40,160 --> 05:07:44,040
LINE MANNED 24/7/365.

5792
05:07:44,040 --> 05:07:51,640
I DON'T THINK THAT WILL HAPPEN.

5793
05:07:51,640 --> 05:07:53,720
AND CREATING AN OUTREACH 

5794
05:07:53,720 --> 05:07:55,360
COMPONENT THAT CREATES MODULES 

5795
05:07:55,360 --> 05:07:57,920
THAT CAN BE USEFUL TO PEOPLE AND

5796
05:07:57,920 --> 05:08:00,800
IF THESE CENTERS ARISE IN AREAS 

5797
05:08:00,800 --> 05:08:03,280
OF DIFFERENT EXPERTISE WHETHER 

5798
05:08:03,280 --> 05:08:03,920
IT'S ALZHEIMER'S RESEARCH OR 

5799
05:08:03,920 --> 05:08:06,840
SOMETHING ELSE, THERE WOULD BE 

5800
05:08:06,840 --> 05:08:08,000
SOMETHING APPROPRIATE ACROSS 

5801
05:08:08,000 --> 05:08:09,920
DIFFERENT AREAS ASSOCIATED WITH 

5802
05:08:09,920 --> 05:08:11,560
DIFFERENT I.C.s.

5803
05:08:11,560 --> 05:08:13,920
IS THAT WHAT YOU'RE ENVISIONING?

5804
05:08:13,920 --> 05:08:21,640
>> THE MODULES IS A GOOD
START.

5805
05:08:21,640 --> 05:08:22,840
>> PEOPLE NEED PEOPLE.

5806
05:08:22,840 --> 05:08:24,640
>> IF YOU WANT THE 9-1-1.

5807
05:08:24,640 --> 05:08:26,200
>> A STATISTICIAN WALKING
YOU 

5808
05:08:26,200 --> 05:08:27,880
THROUGH THE RIGHT QUESTIONS TO 

5809
05:08:27,880 --> 05:08:37,960
ASK.

5810
05:08:39,160 --> 05:08:39,920
>> I THINK YOU IDENTIFIED
THE 

5811
05:08:39,920 --> 05:08:50,160
WANT.

5812
05:08:50,160 --> 05:08:52,960
>> FOR WELL RESOURCED 

5813
05:08:52,960 --> 05:08:55,720
INSTITUTIONS THERE MAY NOT BE 

5814
05:08:55,720 --> 05:09:00,240
ENOUGH TO SUPPORT A CORE OF 

5815
05:09:00,240 --> 05:09:03,760
STATISTICIANS AND METHODOLOGISTS

5816
05:09:03,760 --> 05:09:05,360
WORKING TOGETHER BUT IF WE WERE 

5817
05:09:05,360 --> 05:09:08,640
TO SUPPORT AN ENTITY WITH A 

5818
05:09:08,640 --> 05:09:10,560
LARGE CORE OF HIGHLY QUALIFIED 

5819
05:09:10,560 --> 05:09:12,080
PEOPLE SUPPORTING MULTIPLE 

5820
05:09:12,080 --> 05:09:13,840
DIFFERENT INSTITUTIONS -- IN 

5821
05:09:13,840 --> 05:09:23,560
FACT IT WOULD BE LIKE A U24.

5822
05:09:23,560 --> 05:09:34,040
WE'LL THINK MORE ABOUT THAT.

5823
05:09:35,520 --> 05:09:38,600
>> IF THIS WERE AVAILABLE
TO AN 

5824
05:09:38,600 --> 05:09:39,680
UNDER RESOURCED INSTITUTION, 

5825
05:09:39,680 --> 05:09:50,200
THEY'D FIGURE OUT HOW TO USE IT.

5826
05:09:50,480 --> 05:09:53,760
THAT WAS PERHAPS CATALYZE 

5827
05:09:53,760 --> 05:09:56,360
ENGAGEMENT SOONER AND MORE 

5828
05:09:56,360 --> 05:10:06,440
OFTEN.

5829
05:10:15,560 --> 05:10:18,080
I WONDER IF THAT'S A DIFFERENT 

5830
05:10:18,080 --> 05:10:22,520
PART OF THE SAME PROBLEM.

5831
05:10:22,520 --> 05:10:23,760
IN OTHER WORDS AS SAID 9-1-1, 

5832
05:10:23,760 --> 05:10:27,840
YOU HAVE A HUMAN WHO LITERALLY 

5833
05:10:27,840 --> 05:10:30,360
WALKS YOU THROUGH THE RIGHT 

5834
05:10:30,360 --> 05:10:30,600
QUESTIONS.

5835
05:10:30,600 --> 05:10:39,840
 BEGIN TO DEVELOP YOUR APPROACH 

5836
05:10:39,840 --> 05:10:49,480
TO DO THINGS.

5837
05:10:49,480 --> 05:10:51,600
MOST LARGE INSTITUTIONS HAVE 

5838
05:10:51,600 --> 05:10:52,640
SOMETHING LIKE THIS WITH THEIR 

5839
05:10:52,640 --> 05:10:54,680
CLINICAL TRIALS GROUP.

5840
05:10:54,680 --> 05:10:56,880
YOU CAN'T GET PUBLISHED UNLESS 

5841
05:10:56,880 --> 05:11:07,360
YOU DO THIS IN A ROBUST WAY.

5842
05:11:09,440 --> 05:11:11,160
IT'S DRIVEN BY I THINK CLINICAL 

5843
05:11:11,160 --> 05:11:21,280
TRIALS.

5844
05:11:23,320 --> 05:11:27,520
MAYBE YOU CAN ELABORATE ON THE 

5845
05:11:27,520 --> 05:11:28,120
SOFTWARE CHALLENGE.

5846
05:11:28,120 --> 05:11:30,680
>> SOFTWARE'S A GREAT WAY
OF 

5847
05:11:30,680 --> 05:11:32,360
DOING SOMETHING THE WAY OVER AND

5848
05:11:32,360 --> 05:11:37,040
OVER AGAIN IN TERMS OF 

5849
05:11:37,040 --> 05:11:37,800
REPRODUCIBILITY.

5850
05:11:37,800 --> 05:11:40,560
IF YOU HAVE AN EXISTING SOFTWARE

5851
05:11:40,560 --> 05:11:45,440
TO MAINTAIN THE DATABASE THERE'S

5852
05:11:45,440 --> 05:11:48,560
SUPPORT OF THAT.

5853
05:11:48,560 --> 05:11:53,440
THIS IS A GREAT USE OF THE 

5854
05:11:53,440 --> 05:11:55,280
COMMUNITY CAN USE THE TOOL THEY 

5855
05:11:55,280 --> 05:11:56,720
ALREADY KNOW AND LOVE AND RUN 

5856
05:11:56,720 --> 05:12:03,280
THAT ANALYSIS.

5857
05:12:03,280 --> 05:12:04,080
>> THANK YOU.

5858
05:12:04,080 --> 05:12:07,560
AND DAVID IS WONDERING OUT LOUD 

5859
05:12:07,560 --> 05:12:10,240
IS THIS A MISSING RESOURCE OR 

5860
05:12:10,240 --> 05:12:14,240
ARE WE MISSING ADEQUATE FUNDING?

5861
05:12:14,240 --> 05:12:16,800
>> I WAS TRIGGERED BY THE 

5862
05:12:16,800 --> 05:12:19,640
SUGGESTION OF FUND CENTRAL POOL 

5863
05:12:19,640 --> 05:12:20,440
RESOURCED AVAILABLE TO 

5864
05:12:20,440 --> 05:12:21,800
ORGANIZATION DIDN'T HAVE ENOUGH 

5865
05:12:21,800 --> 05:12:23,960
CRITICAL MASS TO CREATE THEIR 

5866
05:12:23,960 --> 05:12:24,280
OWN.

5867
05:12:24,280 --> 05:12:26,360
WE COULD BUT IS IT MORE 

5868
05:12:26,360 --> 05:12:36,800
EFFICIENT TO CREATE A NEW 

5869
05:12:39,920 --> 05:12:40,360
CENT

5870
05:12:40,360 --> 05:12:40,840
CENT

5871
05:12:40,840 --> 05:12:42,960
CENT

5872
05:12:42,960 --> 05:12:45,920
CENTRAL 9-1-1 RESOURCE.

5873
05:12:45,920 --> 05:12:47,600
>> IT'S FRAMED BY MY
IGNORANCE 

5874
05:12:47,600 --> 05:12:56,560
OF MATH AND STATISTICS IN 

5875
05:12:56,560 --> 05:13:01,280
GENERAL.

5876
05:13:01,280 --> 05:13:04,920
I NEED SOMEONE TO METAPHORICALLY

5877
05:13:04,920 --> 05:13:08,480
HOLD MY HAND AND HAVE ME ASK THE

5878
05:13:08,480 --> 05:13:09,920
RIGHT QUESTIONS.

5879
05:13:09,920 --> 05:13:11,920
I'M NOT SURE YOU'D GET THAT 

5880
05:13:11,920 --> 05:13:15,720
UNLESS YOU HAD DEDICATED STAFF, 

5881
05:13:15,720 --> 05:13:17,200
HOWEVER, THE MECHANISM WAS TO 

5882
05:13:17,200 --> 05:13:23,520
ACCOMPLISH THAT.

5883
05:13:23,520 --> 05:13:26,080
MAYBE PEOPLE BEYOND MY SORRY 

5884
05:13:26,080 --> 05:13:27,160
STATE OF KNOWLEDGE COULD 

5885
05:13:27,160 --> 05:13:29,800
FUNCTION MORE INDEPENDENTLY.

5886
05:13:29,800 --> 05:13:32,880
WALTER DO YOU WANT TO TALK ABOUT

5887
05:13:32,880 --> 05:13:35,000
THE CENTER TO IMPROVE PRINCIPLES

5888
05:13:35,000 --> 05:13:37,120
OF RIGOROUS RESEARCH?

5889
05:13:37,120 --> 05:13:37,920
>> WE'VE BEEN THINKING
ABOUT 

5890
05:13:37,920 --> 05:13:39,320
THIS FOR A WHILE AND WE'RE 

5891
05:13:39,320 --> 05:13:40,400
TRYING DIFFERENT THINGS.

5892
05:13:40,400 --> 05:13:42,480
WE HAD A WORKSHOP TRYING TO 

5893
05:13:42,480 --> 05:13:44,760
BRING RIGOR CHAMPIONS IN FROM 

5894
05:13:44,760 --> 05:13:48,560
AROUND THE COUNTRY TO GET OUT 

5895
05:13:48,560 --> 05:13:49,840
PRINCIPLES OF RIGOROUS DESIGN 

5896
05:13:49,840 --> 05:13:52,120
AND ANALYSIS THROUGHOUT THE 

5897
05:13:52,120 --> 05:13:52,520
COUNTRY.

5898
05:13:52,520 --> 05:13:54,200
WE'RE ALSO PUTTING MONEY BEHIND 

5899
05:13:54,200 --> 05:13:56,320
THE CENTER AND TRYING TO 

5900
05:13:56,320 --> 05:13:57,560
COORDINATE THOSE ACTIVITIES AND 

5901
05:13:57,560 --> 05:14:01,040
FOCUS INITIALLY ON DEVELOPING 

5902
05:14:01,040 --> 05:14:01,680
EDUCATIONAL MATERIALS.

5903
05:14:01,680 --> 05:14:04,560
WE HAVE GRANTS OUT TO PEOPLE TO 

5904
05:14:04,560 --> 05:14:05,480
DEVELOP THOSE MATERIALS.

5905
05:14:05,480 --> 05:14:08,160
THE CENTER WAS VALIDATE AND 

5906
05:14:08,160 --> 05:14:17,160
DISTRIBUTE AND DISSEMINATE THEM.

5907
05:14:17,160 --> 05:14:18,560
AND A REAL PUSH TO IMPROVE THE 

5908
05:14:18,560 --> 05:14:28,840
RIGOR OF RESEARCH.

5909
05:14:32,760 --> 05:14:34,840
>> WE'RE CALLING THIS 

5910
05:14:34,840 --> 05:14:36,440
REPRODUCIBILITY BUT IT ALSO GOES

5911
05:14:36,440 --> 05:14:38,640
TO MISINFORMATION.

5912
05:14:38,640 --> 05:14:40,120
AGAIN, MAYBE I'M GETTING TOO 

5913
05:14:40,120 --> 05:14:40,800
OLD.

5914
05:14:40,800 --> 05:14:43,920
I'M STARTING TO SEE IN OUR 

5915
05:14:43,920 --> 05:14:46,520
ACADEMIC INSTITUTION THE RISE OF

5916
05:14:46,520 --> 05:14:49,000
PROFESSIONAL SKEPTICS BUILDING A

5917
05:14:49,000 --> 05:14:51,200
YEAR IN FINDING THE HOLES AND 

5918
05:14:51,200 --> 05:14:53,200
FLAWS AND NON-REPRODUCIBILITY 

5919
05:14:53,200 --> 05:14:55,080
PARTS OF WHAT WE DO AS 

5920
05:14:55,080 --> 05:14:55,760
SCIENTIFIC EXPERIMENTS.

5921
05:14:55,760 --> 05:14:59,120
THOSE CRITICISM CAN START FROM A

5922
05:14:59,120 --> 05:15:01,400
GOOD POINT FROM CONSTRUCTIVE 

5923
05:15:01,400 --> 05:15:03,880
FEEDBACK AND GOOD WILL BUT 

5924
05:15:03,880 --> 05:15:06,280
OTHERS LATCH ON TO THOSE AND 

5925
05:15:06,280 --> 05:15:08,240
AMPLIFY AND EXPAND AND IT LEADS 

5926
05:15:08,240 --> 05:15:14,680
TO DISRUPT GENERALLY IN SCIENCE.

5927
05:15:14,680 --> 05:15:16,680
I DON'T THINK THIS IS SOLVABLE 

5928
05:15:16,680 --> 05:15:19,640
WITH A U24.

5929
05:15:19,640 --> 05:15:21,280
IT'S WAY BROADER AND COVID HAS 

5930
05:15:21,280 --> 05:15:26,760
HIGHLIGHTED HOW BAD THIS CAN 

5931
05:15:26,760 --> 05:15:31,120
GET.

5932
05:15:31,120 --> 05:15:34,240
THIS SHOULD BE AMPLIFIED MORE 

5933
05:15:34,240 --> 05:15:36,520
THAN IN THIS BIT OF FUNDING HERE

5934
05:15:36,520 --> 05:15:42,200
AND THERE.

5935
05:15:42,200 --> 05:15:45,880
>> THERE'S NO EQUIVALENT
OF THE 

5936
05:15:45,880 --> 05:15:51,200
ANIMAL RESEARCH NIH WIDE BUT I'D

5937
05:15:51,200 --> 05:15:55,160
SAY THE NINDS DOES DO SO 

5938
05:15:55,160 --> 05:15:57,920
COHERENT THINGS IN THIS SPACE 

5939
05:15:57,920 --> 05:15:59,360
AND NIA.

5940
05:15:59,360 --> 05:16:03,360
WALTER IS THAT NOT TRUE FOR 

5941
05:16:03,360 --> 05:16:03,880
NINDS?

5942
05:16:03,880 --> 05:16:05,400
>> NO, WE'VE BEEN TRYING
THINGS 

5943
05:16:05,400 --> 05:16:07,400
OVER TIME BUT WE'RE PUTTING MORE

5944
05:16:07,400 --> 05:16:17,720
MONEY INTO IT NOW.

5945
05:16:19,880 --> 05:16:26,520
 >> IT'S ASTOUNDING
THERE'S IN 

5946
05:16:26,520 --> 05:16:27,720
SIDE FOR THE ANIMAL SIDE.

5947
05:16:27,720 --> 05:16:29,920
>> ATUL, STARTING WITH THE
FIRST

5948
05:16:29,920 --> 05:16:35,560
CALL FOR CTSAs, THERE WAS 

5949
05:16:35,560 --> 05:16:40,720
EMBEDDED THE OPPORTUNITY FOR 

5950
05:16:40,720 --> 05:16:48,120
SCIENCE.

5951
05:16:48,120 --> 05:16:50,240
THAT DOESN'T GO FORWARD.

5952
05:16:50,240 --> 05:16:52,960
>> TIME TO RESURRECT IT.

5953
05:16:52,960 --> 05:16:53,840
>> OKAY.

5954
05:16:53,840 --> 05:16:57,400
I THINK WE'RE BEYOND TIME.

5955
05:16:57,400 --> 05:17:00,520
TARA DID NOT RING THE BELL.

5956
05:17:00,520 --> 05:17:02,720
>> DID I RING THE BELL.

5957
05:17:02,720 --> 05:17:04,520
WE HAVE LEARNED THE BELL CANNOT 

5958
05:17:04,520 --> 05:17:05,640
BE HEARD.

5959
05:17:05,640 --> 05:17:08,200
>> IT COULD VERY WELL BE
BECAUSE

5960
05:17:08,200 --> 05:17:11,000
I DON'T HEAR HIGH PITCHES 

5961
05:17:11,000 --> 05:17:12,720
ANYMORE, AT LEAST THAT'S WHAT MY

5962
05:17:12,720 --> 05:17:13,800
WIFE REPORTS.

5963
05:17:13,800 --> 05:17:15,200
>> I DIDN'T HEAR ANYTHING.

5964
05:17:15,200 --> 05:17:17,120
>> WE DIDN'T HEAR IT.

5965
05:17:17,120 --> 05:17:19,280
>> RING THE BELL NOW.

5966
05:17:19,280 --> 05:17:20,240
>> IT'S REPRODUCIBLE.

5967
05:17:20,240 --> 05:17:27,880
>> THAT'S FOR SURE.

5968
05:17:27,880 --> 05:17:30,520
>> OKAY.

5969
05:17:30,520 --> 05:17:34,680
>> THE PROBLEM WITH ZOOM
IS IF 

5970
05:17:34,680 --> 05:17:36,120
NORTHBOUND ELSE IS SPEAKING, IT 

5971
05:17:36,120 --> 05:17:41,640
DOESN'T ALLOW TO HEAR A 

5972
05:17:41,640 --> 05:17:49,640
COMPETING NOISE.

5973
05:17:49,640 --> 05:17:51,520
APOLOGIES FOR GOING BEYOND AND 

5974
05:17:51,520 --> 05:17:53,440
I'LL KEEP CLOSING COMMENTS TO A 

5975
05:17:53,440 --> 05:17:54,120
MINIMUM.

5976
05:17:54,120 --> 05:17:55,640
THANK YOU TO ALL WHO WERE ABLE 

5977
05:17:55,640 --> 05:17:57,360
TO STAY WITH US FOR THE BETTER 

5978
05:17:57,360 --> 05:17:59,920
PART OF A FULL DAY.

5979
05:17:59,920 --> 05:18:04,560
OF COURSE TO ALL THE SPEAKERS 

5980
05:18:04,560 --> 05:18:09,240
WHO DO A LOT OF PREPARATION FOR 

5981
05:18:09,240 --> 05:18:12,520
THESE AND WE LOOK FORWARD TO SEE

5982
05:18:12,520 --> 05:18:15,240
YOU ALL AGAIN TOMORROW.

5983
05:18:15,240 --> 05:18:18,800
THE DAY TOMORROW'S A BIT SHORTER

5984
05:18:18,800 --> 05:18:19,440
BUT NEVERTHELESS VERY IMPORTANT 

5985
05:18:19,440 --> 05:18:26,080
AS YOU HAVE HEARD.

5986
05:18:26,080 --> 05:18:31,880
I THINK WE GAVE YOU THE PREVIEW 

5987
05:18:31,880 --> 05:18:35,720
FOR WHAT TOMORROW AND WE LOOK 

5988
05:18:35,720 --> 05:18:43,120
FORWARD TO HEARING FROM ALL OF 

5989
05:18:43,120 --> 05:18:43,280
YOU.

5990
05:18:43,280 --> 05:18:44,640
WITH THAT, ANYTHING I LEFT OUT?

5991
05:18:44,640 --> 05:18:45,880
>> WE'LL TRY A DIFFERENT
BELL 

5992
05:18:45,880 --> 05:18:48,520
TOMORROW.

5993
05:18:48,520 --> 05:18:55,360
>> THANK YOU ALL VERY
MUCH.

5994
05:18:55,360 --> 05:18:57,840
I LOOK FORWARD TO DAY TWO OF THE

5995
05:18:57,840 --> 05:18:58,600
ADVISORY COUNCIL.

5996
05:18:58,600 --> 00:00:00,000
HAVE A GOOD EVENING.