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Frank M. LaFerla, Director of the Institute for Memory Impairments and Neurological Disorders, and Professor in the Department of Neurobiology and Behavior at UC Irvine, is a neuroscientist whose major focus of research is Alzheimer’s disease and related dementias. His laboratory developed the first mouse model of Alzheimer’s disease with both plaques and tangles, and is currently involved in translational research to evaluate several drug candidates for potential human clinical trials.
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T.E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003). Triple transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Aß and synaptic dysfunction. Neuron 39, 409-421.
LaFerla, F. M., Green, K. N., and Oddo, S. (2007). Intracellular amyloid-ß in Alzheimer’s disease. Nature Reviews Neuroscience 8, 499-509.
Blurton-Jones, M., Kitazawa, M., Martinez-Coria, H., Castello, N.A., Müller, F.J., Loring, J.F., Yamasaki, T.R., Poon, W.W., Green, K.N., LaFerla, F.M. (2009). Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 106:13594-9.
For more information see our website - http://neuroseries.info.nih.gov
Alzheimer's disease and stem cell therapy / Frank M. LaFerla.
LaFerla, Frank M. National Institutes of Health (U.S.)