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Molecular Mechanisms of Memory Loss in Alzheimer's Disease

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Air date: Wednesday, June 24, 2009, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 152 * This only includes stats from October 2011 and forward.
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:03:34
Description: About Dr. Hsiao Ashe’s Lecture:

“We have performed studies involving the creation of transgenic mouse models of Alzheimer's disease in order to understand how the amyloid-ß and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-ß and tau proteins which define Alzheimer's disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-ß protein called Aß star (Aß*) that disrupts cognitive function in mice and rats, and increases in humans before a diagnosis of Alzheimer's disease has been made. We propose that Alzheimer's disease begins when Aß* levels rise, triggering a cascade of events that culminates in neurodegeneration and dementia.”

The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
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NLM Title: Molecular mechanisms of memory loss in Alzheimer's disease [electronic resource] / Karen Hsiao Ashe.
Series: NIH director's Wednesday afternoon lecture series
Author: Ashe, Karen Hsiao.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH director's Wednesday afternoon lecture series
Abstract: (CIT): About Dr. Hsiao Ashe"s Lecture: "We have performed studies involving the creation of transgenic mouse models of Alzheimer's disease in order to understand how the amyloid-[beta] and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-[beta] and tau proteins which define Alzheimer's disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-[beta] protein called A[beta] star (A[beta]*) that disrupts cognitive function in mice and rats, and increases in humans before a diagnosis of Alzheimer's disease has been made. We propose that Alzheimer's disease begins when A[beta]* levels rise, triggering a cascade of events that culminates in neurodegeneration and dementia." The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Subjects: Alzheimer Disease--genetics
Memory Disorders--genetics
Publication Types: Lectures
Webcasts
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NLM Classification: WT 155
NLM ID: 101510721
CIT Live ID: 7052
Permanent link: https://videocast.nih.gov/launch.asp?15192

 

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