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Autoantigens and autoimmunity: a bedside to bench and back again story

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Air date: Wednesday, June 26, 2019, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 307, (165 Live, 142 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:59:40
Description: NIH Director's Wednesday Afternoon Lecture Series

Noncoding RNAs play critical roles in the metabolism of all cells. The Wolin laboratory studies how noncoding RNAs function, how cells recognize and degrade defective noncoding RNAs, and how failure to degrade these RNAs affects cell function and contributes to human disease. Their studies revealed new mechanisms by which defective RNAs are targeted for degradation and new classes of noncoding RNAs. Most recently, their work has contributed to a novel theory for how the autoimmune disease systemic lupus erythematosus may be triggered in genetically susceptible individuals.
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NLM Title: Autoantigens and autoimmunity : a bedside to bench and back again story / Sandra L. Wolin.
Author: Wolin, Sandra L.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series Noncoding RNAs play critical roles in the metabolism of all cells. The Wolin laboratory studies how noncoding RNAs function, how cells recognize and degrade defective noncoding RNAs, and how failure to degrade these RNAs affects cell function and contributes to human disease. Their studies revealed new mechanisms by which defective RNAs are targeted for degradation and new classes of noncoding RNAs. Most recently, their work has contributed to a novel theory for how the autoimmune disease systemic lupus erythematosus may be triggered in genetically susceptible individuals.
Subjects: Autoantigens
Lupus Erythematosus, Systemic--immunology
RNA, Untranslated
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: QW 573
NLM ID: 101750715
CIT Live ID: 31429
Permanent link: https://videocast.nih.gov/launch.asp?27636