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Turning immunity on and off (HHS Only)

Air date: Wednesday, January 23, 2019, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Description: NIH Director’s Wednesday Afternoon Lecture Series

Dr. Hubbell will discuss his lab's efforts to develop immunotherapies that will stimulate the immune system to fight infection or malignancy, or turn off some aspects of the immune system to address autoimmune diseases.

With regard to turning immunity on, Dr. Hubbell and his lab are developing adjuvant systems that employ both physical and molecular mechanisms of action. Adaptive immune responses are triggered particularly powerfully in the lymph nodes and in the lymphoid tissues associated with mucosae. He is designing nanomaterials and soluble polymers to exploit interstitial flow from the site of administration to the lymph nodes, using the material vectors to carry both antigen and associated adjuvant biomolecules. These material carriers, which are being developed as multifunctional vaccines, include biomolecular features of pathogens to enhance targeting of precise cell populations in the lymph nodes and dendritic cells. Dr. Hubbell is interested in these materials to turn immunity on to pathogens such as malaria, for which there is no highly effective vaccine, and to cancer.

In addition, he will describe his lab's explorations of ways to enhance the efficacy and reduce the toxicity of powerful immunotherapeutics to tumors; biological approaches to deliver protein antigens in a tolerogenic manner; and his research on the ability to induce antigen-specific energy as well as T-regulatory responses.

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Author: Jeffrey A. Hubbell, Ph.D., Eugene Bell Professor in Tissue Engineering, Institute for Molecular Engineering and Committee on Immunology, University of Chicago
Runtime: 1 hour