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Genomics has undergone a resolution revolution, such that the nucleic acid content of individual cells are now sequenced routinely in high-throughput mode. Thus we can define the cellular composition of tissues in an unbiased and comprehensive way using single-cell transcriptomics, revealing the molecular fingerprint of cell states and their predicted signaling circuits in tissues across development and disease. Dr. Teichmann will illustrate this with the maternal-fetal interface in the first-trimester placenta and decidua.
Sarah Teichmann, Ph.D., Head of Cellular Genetics, Wellcome Sanger Institute; Visiting Group Leader, European Molecular Biology Laboratory, European Bioinformatics Institute; Director of Research, Physics Department, Cavendish Laboratory, Cambridge University; Senior Research Fellow, Churchill College