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CCR Eminent Lecture: The Multifaceted Function of the PD-1 PathwayHHS Only

Air date: Monday, September 24, 2018, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Description: NCI Center for Cancer Research Eminent Lecture

Arlene Sharpe is the George Fabyan Professor of Comparative Pathology, Head of the Division of Immunology and Interim Co-Chair of the Department of Microbiology and Immunobiology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women’s Hospital, an Associate Member at the Broad Institute of MIT and Harvard, Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center and Co-Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital.

Dr. Sharpe earned her A.B. from Harvard University and her M.D. and Ph.D. degrees from Harvard Medical School. She completed residency training in Pathology at Brigham and Women’s Hospital and is board certified in Anatomic Pathology. Dr. Sharpe has served as a member and chair of the NIH Hypersensitivity, Autoimmunity and Immune-mediated diseases (HAI) study section and is currently a member of NIAID Council. She also served as President of the American Association of Immunologists from 2016-2017.

Dr. Sharpe is a leader in the field of T-cell costimulation. Her laboratory has discovered and elucidated the functions of T-cell costimulatory pathways, including the immunoinhibitory functions of the CTLA-4 and PD-1 pathways, which have become exceptionally promising targets for cancer immunotherapy. Her laboratory currently focuses on the roles of T-cell costimulatory pathways in regulating T-cell tolerance and effective antimicrobial and antitumor immunity and translating fundamental understanding of T-cell costimulation into new therapies for autoimmune diseases and cancer. Dr. Sharpe has published more than 300 papers and was listed by Thomas Reuters as one of the most Highly Cited Researchers (top 1%) in 2014, 2015, and 2017 and as a Citation Laureate in 2016. She received the William B. Coley Award for Distinguished Research in Tumor immunology in 2014 and the Warren Alpert Foundation Prize in 2017 for her contributions to the discovery of PD-1 pathway.
Author: Arlene H. Sharpe, M.D., Ph.D., George Fabyan Professor of Comparative Pathology, Interim Co-Chair of the Department of Microbiology and Immunobiology, Co-Director, Evergrande Center for Immunologic Diseases, Harvard Medical School
Runtime: 1 hour