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CANCELLED - Deconstructing Microtubule-actin Crosstalk In Vitro and In Vivo

Air date: Monday, October 15, 2018, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Description: NIH Neuroscience Series Seminar

Research in Dr. Goode lab focuses on defining the biochemical and cellular mechanisms of actin and microtubule cytoskeleton rearrangements that drive cell morphogenesis, motility, endocytosis, and intracellular transport. To tackle these problems, they take a multi-disciplinary ‘top down’ and ‘bottom up’ approach, combining forward and reverse genetics, biochemistry, structural biology, cell imaging, and multi-wavelength single molecule TIRF microscopy. From 2000-2010, their primary in vivo discovery system was the budding yeast S. cerevisiae; however, since then they have made a major transition, and about half of the lab currently studies cytoskeletal dynamics in mammalian cells. Their research interests lie in three areas:

• Coordination of microtubule and actin polymer dynamics

• Actin filament disassembly & remodeling

• Cellular actin assembly mechanisms

Their long-range goal is to define in molecular detail the multi-component mechanisms that underlie these critical steps in cytoskeletal remodeling, which govern cell shape, organization, and dynamics.

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Author: Bruce Goode Ph.D., Brandeis University
Runtime: 1 hour