Skip Navigation


CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable podcast. CIT can also broadcast NIH-only or HHS-only content.

Anita Roberts Lecture: Specializations for decision making in primate prefrontal cortex

Loading video...

79 Views  
   
Air date: Thursday, May 17, 2018, 11:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 79, (23 Live, 56 On-demand)
Category: Anita B. Roberts - Distinguished Women Scientists
Runtime: 01:00:53
Description: Women Scientist Advisors Anita Roberts Lecture

Specializations for decision making in primate prefrontal cortex Some of the most sophisticated behaviors of primates, including humans, depend on the granular prefrontal cortex (PFC), yet there are few well defined and experimentally verified functional specializations within the primate PFC, especially at a causal level. Recent work from our laboratory has demonstrated contrasting specializations of the ventrolateral PFC (VLPFC) and the orbital PFC (also known as orbitofrontal cortex, OFC). We found that the OFC and the VLPFC play complementary roles in updating representations of value (i.e., valuations) that underlie decision making. Valuations represented in or accessed by the OFC depend on the dynamic internal state of an individual, what an object or action is worth at any given time based on current biological needs; valuations represented in or accessed by the VLPFC depend on dynamic external contingencies. In other words, the OFC updates valuations based on reward desirability whereas the VLPFC updates valuations based on reward availability. Additional studies have identified distinct functional subdivisions within the OFC. Its posterior part (area 13) is necessary for updating the valuations of objects and actions, while its anterior part (area 11) translates these valuations into choices and actions. According to comparative neuroanatomy, the granular parts of OFC and all of the VLPFC emerged during the evolution of primates, and it seems likely that their valuation-updating specializations elaborated on related functions performed by the agranular orbitofrontal areas that all mammals share.
Debug: Show Debug
NLM Title: Specializations for decision making in primate prefrontal cortex / Elisabeth Murray.
Author: Murray, Elisabeth A.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Women Scientist Advisors Anita Roberts Lecture. Specializations for decision making in primate prefrontal cortex. Some of the most sophisticated behaviors of primates, including humans, depend on the granular prefrontal cortex (PFC), yet there are few well defined and experimentally verified functional specializations within the primate PFC, especially at a causal level. Recent work from our laboratory has demonstrated contrasting specializations of the ventrolateral PFC (VLPFC) and the orbital PFC (also known as orbitofrontal cortex, OFC). We found that the OFC and the VLPFC play complementary roles in updating representations of value (i.e., valuations) that underlie decision making. Valuations represented in or accessed by the OFC depend on the dynamic internal state of an individual, what an object or action is worth at any given time based on current biological needs; valuations represented in or accessed by the VLPFC depend on dynamic external contingencies. In other words, the OFC updates valuations based on reward desirability whereas the VLPFC updates valuations based on reward availability. Additional studies have identified distinct functional subdivisions within the OFC. Its posterior part (area 13) is necessary for updating the valuations of objects and actions, while its anterior part (area 11) translates these valuations into choices and actions. According to comparative neuroanatomy, the granular parts of OFC and all of the VLPFC emerged during the evolution of primates, and it seems likely that their valuation-updating specializations elaborated on related functions performed by the agranular orbitofrontal areas that all mammals share.
Subjects: Decision Making--physiology
Prefrontal Cortex--physiology
Primates--physiology
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
[64k]  [150k]  [240k]  [440k]  [740k]  [1040k]  [1240k]  [1440k]  [1840k]    How to download a Videocast
Caption Text: Download Caption File
NLM Classification: WL 337
NLM ID: 101728506
CIT Live ID: 27675
Permanent link: https://videocast.nih.gov/launch.asp?23894