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The goal of this workshop is to discuss potential next steps to facilitate the development of new technologies and/or biomarker panels to assess tissue oxygenation in a minimally to non-invasive fashion pre- and post-transfusion of Red Blood Cells (RBCs). The 2015 Transfusion Symposium identified tissue oxygenation assessment as a priority area. The development of minimally to non-invasive procedures to accurately measure tissue oxygenation are needed 1) pre-transfusion to predict who would benefit from RBC transfusions, and (2) post-transfusion to determine if the patient did benefit (and to be able to test the differential effects of various RBC products with specific characteristics). The meeting goals support the NIH mission to enhance patient health.
This workshop will build on a previous initiative focused on assessment tools to evaluate the dynamic changes in microvascular blood flow and tissue oxygenation in clinical research applications. Subject matter experts in multiple disciplines relevant to tissue oxygenation (transfusion, critical care, cardiology, neurology, neonatal/pediatrics, bioengineering, biochemistry, imaging) will generate recommendations on what the next research priorities would be to combine global “omics” signatures with additional measures (e.g., thenar eminence reading or imaging methods) to predict who needs RBC transfusion and evaluate whether RBC transfusion was effective and to what degree. A formal summary of the recommendations identified during the workshop will be provided in a report on the NHLBI website.