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Mitochondria control of physiology and disease: beyond ATP

   
Air date: Wednesday, March 7, 2018, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Description: NIH Director’s Wednesday Afternoon Lecture Series

For decades, the mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles generating metabolites for the production of macromolecules and ATP, respectively. Our work has elucidated that mitochondria have a third distinct role whereby they release reactive oxygen species (ROS) and metabolites such as L-2-hydroxyglutarate to initiate physiological and pathological processes including hypoxic activation of HIFs, cellular differentiation, T cell activation and cancer cell proliferation. Thus, mitochondria function as signaling organelles.

For more information go to https://oir.nih.gov/wals/2017-2018
Author: Navdeep S. Chandel, Ph.D., Northwestern University
Runtime: 1 hour