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Mitochondria control of physiology and disease: beyond ATP

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Air date: Wednesday, March 7, 2018, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 478, (251 Live, 227 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:57:53
Description: NIH Director’s Wednesday Afternoon Lecture Series

Historically, mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles that generate metabolites for the production of macromolecules and adenosine triphosphate (ATP), respectively. The work of the Chandel laboratory has elucidated that mitochondria have a third distinct role whereby they release reactive oxygen species (ROS) and metabolites to regulate transcription factors and epigenetics. For his lecture, Dr. Chandel will present his lab’s ongoing efforts to understand how mitochondria, in addition to producing ATP, regulate cancer and immunity.

For more information go to https://oir.nih.gov/wals/2017-2018
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NLM Title: Mitochondria control of physiology and disease : beyond ATP / Navdeep S. Chandel.
Author: Chandel, Navdeep S.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Historically, mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles that generate metabolites for the production of macromolecules and adenosine triphosphate (ATP), respectively. The work of the Chandel laboratory has elucidated that mitochondria have a third distinct role whereby they release reactive oxygen species (ROS) and metabolites to regulate transcription factors and epigenetics. For his lecture, Dr. Chandel will present his lab's ongoing efforts to understand how mitochondria, in addition to producing ATP, regulate cancer and immunity.
Subjects: Adenosine Triphosphate--metabolism
Mitochondria--physiology
Neoplasms--genetics
Reactive Oxygen Species--metabolism
Signal Transduction--physiology
Transcription Factors--metabolism
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 350
NLM ID: 101724464
CIT Live ID: 27174
Permanent link: https://videocast.nih.gov/launch.asp?23744