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Race, risk, and resilience: understanding racial differences in cognitive aging and brain pathology

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Air date: Wednesday, February 28, 2018, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 319, (189 Live, 130 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:53:28
Description: NIH Director’s Wednesday Afternoon Lecture Series

Older African-Americans, a rapidly growing segment of the U.S. population, bear a disproportionate burden of Alzheimer’s disease and cognitive impairment compared to non-Hispanic whites, with some estimates suggesting that they may have more than a two-fold increased risk than their white counterparts. Recent studies have led to significant advances in our understanding of the underlying neurobiologic substrates of Alzheimer’s disease. But because of challenges in the recruitment of African-Americans into research studies and an unfortunate lack of clinical and biologic data in this population, knowledge of the drivers of the disparities has lagged behind. The ability to identify therapeutic targets and effective interventions for this population has become a public-health imperative. In this lecture, Dr. Barnes will present data from several longitudinal cohort studies of older African-Americans on how risk factors and resilience markers impact cognitive aging. She will also discuss preliminary data on racial differences in brain pathology measured at death. The data may lead to opportunities in identifying new mechanisms and new knowledge for Alzheimer’s disease, cognitive impairment, and cognitive decline.

For more information go to https://oir.nih.gov/wals/2017-2018
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NLM Title: Race, risk, and resilience : understanding racial differences in cognitive aging and brain pathology / Lisa L. Barnes.
Author: Barnes, Lisa L.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series Older African-Americans, a rapidly growing segment of the U.S. population, bear a disproportionate burden of Alzheimer"s disease and cognitive impairment compared to non-Hispanic whites, with some estimates suggesting that they may have more than a two-fold increased risk than their white counterparts. Recent studies have led to significant advances in our understanding of the underlying neurobiologic substrates of Alzheimer's disease. But because of challenges in the recruitment of African-Americans into research studies and an unfortunate lack of clinical and biologic data in this population, knowledge of the drivers of the disparities has lagged behind. The ability to identify therapeutic targets and effective interventions for this population has become a public-health imperative. In this lecture, Dr. Barnes will present data from several longitudinal cohort studies of older African-Americans on how risk factors and resilience markers impact cognitive aging. She will also discuss preliminary data on racial differences in brain pathology measured at death. The data may lead to opportunities in identifying new mechanisms and new knowledge for Alzheimer's disease, cognitive impairment, and cognitive decline.
Subjects: African Americans
Alzheimer Disease--ethnology
Cognitive Aging
Resilience, Psychological
Risk Factors
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: WT 145
NLM ID: 101722237
CIT Live ID: 27172
Permanent link: https://videocast.nih.gov/launch.asp?23734