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New insights into the human type I interferon response revealed by flavivirus-host interactions

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Air date: Friday, January 19, 2018, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 212, (78 Live, 134 On-demand)
Category: NIH Director's Seminars
Runtime: 00:52:08
Description: NIH Director's Seminar Series

More than a quarter of the world’s population is at annual risk of infection with flaviviruses, which include West Nile virus, Zika virus, dengue virus, yellow fever virus and tick-borne encephalitis virus. Despite being closely related, these viruses have evolved different mechanisms to evade the type I interferon response. This seminar will discuss two distinct interactions between various flaviviruses and human interferon signaling pathways. These two studies provide new insight into regulation of interferon signaling through the IFNAR receptor, as well as the antiviral functions of the interferon response that may contribute to flavivirus evolution and emergence.
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NLM Title: New insights into the human type I interferon response revealed by flavivirus-host interactions / Sonja M. Best.
Author: Best, Sonja M.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): More than a quarter of the world's population is at annual risk of infection with flaviviruses, which include West Nile virus, Zika virus, dengue virus, yellow fever virus and tick-borne encephalitis virus. Despite being closely related, these viruses have evolved different mechanisms to evade the type I interferon response. This seminar will discuss two distinct interactions between various flaviviruses and human interferon signaling pathways. These two studies provide new insight into regulation of interferon signaling through the IFNAR receptor, as well as the antiviral functions of the interferon response that may contribute to flavivirus evolution and emergence.
Subjects: Flavivirus Infections--immunology
Flavivirus--immunology
Host-Pathogen Interactions--immunology
Immune Evasion
Interferon Type I--metabolism
Publication Types: Lectures
Webcasts
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NLM Classification: QW 168.5.F5
NLM ID: 101720650
CIT Live ID: 26965
Permanent link: https://videocast.nih.gov/launch.asp?23661