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CANCELLED - Robustness, Variability and Homeostasis in Neurons and Networks

Air date: Monday, January 22, 2018, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Description: NIH Neuroscience Series Seminar

One of the fundamental problems in neuroscience is understanding how circuit function arises from the intrinsic properties of individual neurons and their synaptic connections. Of particular interest to us today is the extent to which similar circuit outputs can be generated by multiple mechanisms, both in different individual animals, or in the same animal over its life-time. As an experimental preparation Dr. Marder’s Lab exploits¬¬ the advantages of the central pattern generating circuits in the crustacean stomatogastric nervous system. Central pattern generators are groups of neurons found in vertebrate and invertebrate nervous systems responsible for the generation of specific rhythmic behaviors such as walking, swimming, and breathing. The central pattern generators in the stomatogastric ganglion (STG) of lobsters and crabs are ideal for many analyses because the STG has only about 30 large neurons, the connectivity is established, the neurons are easy to record from, and when the stomatogastric ganglion is removed from the animal, it continues to produce rhythmic motor patterns.

Work in their lab centers on the following three main questions. To address these questions they employ electrophysiological, biophysical, computational, anatomical, biochemical, and molecular techniques.
  • How do neuromodulators and neuromodulatory neurons reconfigure circuits so that the same group of neurons can produce a variety of behaviorally relevant outputs?
  • How can networks be both stable over the lifetime of the animal despite ongoing turnover of membrane proteins such as channels and receptors? How is network stability maintained over long time periods? To what extent do similar network outputs result from different underlying mechanisms or solutions?
  • How variable are the sets of parameters that govern circuit function across animals? How can animals with disparate sets of circuit parameters respond reliably to perturbations such as neuromodulators and temperature?
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Author: Eve Marder, Ph.D., Brandeis University
Runtime: 1 hour