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Encoding and scaling pain through specific cell types

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Air date: Monday, November 6, 2017, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 61, (24 Live, 37 On-demand)
Category: Neuroscience
Runtime: 00:54:12
Description: NIH Neuroscience Series Seminar

Two main directions of research are conducted in Dr. Ernfors group - understanding how complex sets of modality specific sensory neurons codes for somatic sensation and understanding the biology of glioblastoma.

The problem of pain continues to grow as population age, but there has been a difficulty to develop new useful analgesic drugs. Almost 1 in 5 of the population has an ongoing pain problem, with 7% suffering debilitating pain. Little remains known regarding the actual cellular and molecular complexity during pain transduction, simply because of lack of knowledge on the sensory neuron types conducting somatosensation and pain. A major focus of the lab is to determine the full cellular and molecular complexity of pain and unravel the critical cell types driving pain in particular types of pain disorders. For this purpose, they are using unbiased identification and classification of sensory cell types in rodents and non-human primates and exploit this knowledge to reveal their participation in acute, inflammatory and neuropathic pain using mouse genetics. Hence, the overall aim is to provide knowledge on the existence of defined types of nociceptive cells and assign their participation to particular types of pain states.

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Author: Patrik Ernfors, Ph.D., Karolinska Institute
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CIT Live ID: 24847
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