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Ion Channels in Mammalian Primary Cilia

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Air date: Monday, October 30, 2017, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 64, (24 Live, 40 On-demand)
Category: Neuroscience
Runtime: 01:02:01
Description: NIH Neuroscience Series Seminar

The Clapham laboratory moved to the Janelia Research Campus in July 2017 and continued working on the ion channels and calcium signals. They have two major interests at present. First, they are interested in the ion channels in primary cilia and how they affect signaling pathways, such as Hedgehog, in embryonic and mature neurons and glia of the hippocampus. They are also pursuing the cryoEM structures of the two main channels of primary cilia so that they can understand their gating.

Second, Clapham lab is interested in understanding the two unusual ion channels, TRPM7 and TRPM6. These channels are in all cells, and when genetically deleted, are lethal. The channels are unique in that they possess active kinase domains that when cleaved, enter the nucleus and phosphorylate distinct residues on histones that control chromatin accessibility and thus transcription. Answering these questions will require electrophysiology, advanced light microscopy, mouse genetics, and structural approaches.

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Author: David Clapham, M.D., Ph.D., Howard Hughes Medical Institute
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CIT Live ID: 24845
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