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Luigi D. Notarangelo is the Chief of the Laboratory of Clinical Immunology and Microbiology at NIAID. He graduated in Medicine at the University of Pavia (Italy) and completed residency in Pediatrics and fellowships in Allergy/Immunology and Human Genetics. Between 2000 and 2006, he was Professor and Chair of Pediatrics at the University of Brescia (Italy), then moved to Boston where he was Professor of Pediatrics at Harvard Medical School until 2016, when he moved to NIH. He is past-President of the European Society of Immune Deficiencies and of the Clinical Immunology Society. He has published 491 manuscripts. His major area of interest is in the characterization of the molecular and cellular bases of primary immune deficiencies, and combined immune deficiencies in particular, and in development of novel forms of therapy for these disorders. He has discovered the bases of human JAK3 deficiency, Omenn syndrome, X-linked thrombocytopenia, CD40 deficiency, DOCK2 deficiency, and EXTL3 deficiency. His studies currently focus on the identification of molecular signatures of immune dysregulation in the T cell repertoire of patients with primary immune deficiencies, and on development of less toxic approaches to opening of stem cell and lymphoid niches to facilitate engraftment of donor cells.
Luigi D. Notarangelo, MD, Chief, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH